FN Thomson Reuters Web of Science™
VR 1.0
PT J
AU Bock, JM
   Brawley, MK
   Johnston, N
   Samuels, T
   Massey, BL
   Campbell, BH
   Toohill, RJ
   Blumin, JH
AF Bock, Jonathan M.
   Brawley, Mary K.
   Johnston, Nikki
   Samuels, Tina
   Massey, Becky L.
   Campbell, Bruce H.
   Toohill, Robert J.
   Blumin, Joel H.
TI Analysis of Pepsin in Tracheoesophageal Puncture Sites
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT Annual Meeting of the American-Broncho-Esophagological-Association
CY APR 28-29, 2010
CL Las Vegas, NV
SP Amer Broncho Esophagol Assoc
DE head and neck cancer; laryngectomy; pepsin; reflux; tracheoesophageal
   puncture
ID LARYNGOPHARYNGEAL REFLUX DISEASE; GASTROESOPHAGEAL-REFLUX; ESOPHAGEAL
   MOTILITY; TOTAL LARYNGECTOMY; CARCINOMA; SPEECH; VOICE; RESTORATION;
   MANAGEMENT; CANCER
AB Objectives: Tracheoesophageal puncture (TEP) and prosthesis insertion is a well-established method of voice rehabilitation after laryngectomy. Maintenance of the prosthesis and tract can be challenging, and reflux to the TEP site has been proposed as a cause. The sites of TEP were evaluated for the presence of pepsin in tissue biopsy specimens and tract secretions to explore this association.
   Methods: Patients with TEP were interviewed for a history of symptoms related to reflux, medication use history, TEP voice quality, and incidence of TEP complications. Tissue biopsy specimens and tract secretions were obtained from TEP sites and analyzed for the presence of pepsin via sodium dodecyl sulfate polyacrylamide gel electrophoresis Western blot analysis.
   Results: Twelve of 17 patients (47%) had some history of preoperative or postoperative symptoms of gastroesophageal reflux disease or laryngopharyngeal reflux. Pepsin was present within the TEP site in a total of 10 of 17 patients (58%; 7 of 17 tissue biopsy specimens and 6 of 7 secretion samples). There were no statistically significant associations between the presence of pepsin and sex, reflux history, use of acid suppressive medicine, or time since laryngectomy.
   Conclusions: Reflux with subsequent pepsin deposition into the TEP tract occurs in a majority of laryngectomy patients. Further studies on the effect of reflux on the health and function of the TEP tract are warranted.
C1 [Bock, Jonathan M.; Brawley, Mary K.; Johnston, Nikki; Samuels, Tina; Massey, Becky L.; Campbell, Bruce H.; Toohill, Robert J.; Blumin, Joel H.] Med Coll Wisconsin, Dept Otolaryngol & Commun Sci, Milwaukee, WI 53226 USA.
RP Bock, JM (reprint author), Med Coll Wisconsin, Dept Otolaryngol & Commun Sci, 9200 W Wisconsin Ave, Milwaukee, WI 53226 USA.
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NR 30
TC 9
Z9 9
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD DEC
PY 2010
VL 119
IS 12
BP 799
EP 805
PG 7
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 697CY
UT WOS:000285491400003
PM 21250551
ER

PT J
AU Thomeer, HGXM
   Crins, TTH
   Kamsteeg, EJ
   Buijsman, W
   Cruysberg, JRM
   Knoers, NVAM
   Cremers, CWRJ
AF Thomeer, Henricus G. X. M.
   Crins, Tom T. H.
   Kamsteeg, Erik J.
   Buijsman, Wendy
   Cruysberg, Johannes R. M.
   Knoers, Nine V. A. M.
   Cremers, Cor W. R. J.
TI Clinical Presentation and the Presence of Hearing Impairment in
   Branchio-oculo-facial Syndrome: A New Mutation in the TFAP2A Gene
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE BAHA; bone-anchored hearing aid; branchio-oculo-facial syndrome;
   congenital conductive hearing loss; congenital ear canal atresia;
   microphthalmia; nasolacrimal duct; TFAP2A gene
ID DISTINCT ENTITIES; FACIAL-SYNDROME; EAR; MANIFESTATIONS; EXCLUSION;
   ATRESIA
AB We report on the clinical presentation of branchio-oculo-facial (BOF) syndrome in 2 patients with mutations in the TFAP2A gene (OMIM 107580). This TFAP2A gene was recently shown to be involved in the causation of BOF syndrome. An overview of the literature on BOF syndrome is Oven based on clinical reports written in the period during which mutation analysis was not yet available for BOF syndrome. We also give descriptions of the mutations in the TFAP2A gene in our 2 new patients with BOF syndrome. Congenital conductive hearing impairments are described, including hearing rehabilitation and the results of ear surgery.
C1 [Thomeer, Henricus G. X. M.; Crins, Tom T. H.; Cremers, Cor W. R. J.] Radboud Univ Nijmegen, Donders Ctr Brain Cognit & Behav, Dept Otorhinolaryngol, Ctr Clin Neurosci,Med Ctr, NL-6500 HB Nijmegen, Netherlands.
   [Kamsteeg, Erik J.; Buijsman, Wendy; Knoers, Nine V. A. M.] Radboud Univ Nijmegen, Med Ctr, Ctr Clin Neurosci, Dept Human Genet, NL-6500 HB Nijmegen, Netherlands.
   [Cruysberg, Johannes R. M.] Radboud Univ Nijmegen, Med Ctr, Ctr Clin Neurosci, Dept Ophthalmol, NL-6500 HB Nijmegen, Netherlands.
RP Thomeer, HGXM (reprint author), Radboud Univ Nijmegen, Donders Ctr Brain Cognit & Behav, Dept Otorhinolaryngol, Ctr Clin Neurosci,Med Ctr, POB 9101, NL-6500 HB Nijmegen, Netherlands.
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NR 25
TC 3
Z9 3
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD DEC
PY 2010
VL 119
IS 12
BP 806
EP 814
PG 9
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 697CY
UT WOS:000285491400004
PM 21250552
ER

PT J
AU Stankovic, KM
   Hennessey, AM
   Herrmann, B
   Mankarious, LA
AF Stankovic, Konstantina M.
   Hennessey, Ann Marie
   Herrmann, Barbara
   Mankarious, Leila A.
TI Cochlear Implantation in Children With Congenital X-Linked Deafness Due
   to Novel Mutations in POU3F4 Gene
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE cochlear implantation; congenital X-linked deafness; DFN3; POU3F4
ID SENSORINEURAL HEARING-LOSS; MIXED DEAFNESS; MISSENSE MUTATION; TYPE-3
   DFN3; INNER-EAR; IDENTIFICATION; PHENOTYPE; DELETION; BRAIN-4; FAMILY
AB Objectives: We report novel mutations in the POU3F4 gene resulting in congenital X-linked deafness DFN3, and describe the results of cochlear implantation in 4 boys (3 siblings) followed for an average of 3.5 years.
   Methods: The diagnosis of DFN3 was made in infant boys on the basis of the radiologic criteria of an underdeveloped modiolus, a wide cochlear fossette, and the presence of all cochlear turns. The POU3F4 gene was sequenced. A standard, transmastoid, facial recess approach was used for cochlear implantation. A lumbar drain was placed before the operation.
   Results: The identified mutations in the POU3F4 gene were novel (p.R167X in the 3 siblings) or recently reported (p.S310del). A high-flow cerebrospinal fluid leak through the cochleostomy was encountered in each patient and was ultimately controlled. Although the implants functioned properly, the auditory perceptual abilities did not progress past sound detection in the 3 siblings, or past closed-set word identification in the non-sibling, who achieved better speech perception with contralateral amplification. Three boys (2 siblings) show signs of other learning disorders; 1 boy was too young for a complete assessment.
   Conclusions: Preoperative gene mutation analysis in DFN3 patients who are considering cochlear implantation may help in long-term counseling and in avoidance of postoperative complications. Limited auditory perception and language acquisition may result. Amplification may sometimes be a better alternative than cochlear implantation, despite the severity of the hearing loss.
C1 [Stankovic, Konstantina M.; Mankarious, Leila A.] Massachusetts Eye & Ear Infirm, Dept Otolaryngol, Boston, MA 02114 USA.
   [Hennessey, Ann Marie; Herrmann, Barbara] Massachusetts Eye & Ear Infirm, Dept Audiol, Boston, MA 02114 USA.
   [Stankovic, Konstantina M.; Herrmann, Barbara; Mankarious, Leila A.] Harvard Univ, Sch Med, Dept Otol & Laryngol, Boston, MA 02115 USA.
RP Mankarious, LA (reprint author), Massachusetts Eye & Ear Infirm, Dept Otolaryngol, 243 Charles St, Boston, MA 02114 USA.
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NR 28
TC 7
Z9 7
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD DEC
PY 2010
VL 119
IS 12
BP 815
EP 822
PG 8
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 697CY
UT WOS:000285491400005
PM 21250553
ER

PT J
AU Aoyama, T
   Kumai, Y
   Yumoto, E
   Ito, T
   Miyamaru, S
AF Aoyama, Takashi
   Kumai, Yoshihiko
   Yumoto, Eiji
   Ito, Takaaki
   Miyamaru, Satoru
TI Effects of Nerve-Muscle Pedicle on Immobile Rat Vocal Folds in the
   Presence of Partial Innervation
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT Annual Meeting of the American-Broncho-Esophagological-Association
CY APR 28-29, 2010
CL Las Vegas, NV
SP Amer Broncho Esophagol Assoc
DE nerve-muscle pedicle; neuromuscular junction; partial denervation;
   recurrent laryngeal nerve paralysis
ID RECURRENT LARYNGEAL NERVE; THYROARYTENOID MUSCLE; REINNERVATION;
   ELECTROMYOGRAPHY; CELLS
AB Objectives: We investigated whether implantation of an ansa cervicalis nerve (ACN)muscle pedicle into the thyroarytenoid (TA) muscle is efficacious in the presence of partial recurrent laryngeal nerve (RLN) innervation.
   Methods: We studied a total of 36 rats. Twelve of the rats served as positive and negative control animals. In the remaining 24 rats, the left RLN was transected, a 1-mm piece of nerve was removed, and the stumps were abutted in silicone tubes (STs), inducing partial RLN regeneration. Twelve of the ST-treated rats underwent this procedure alone, and the other 12 rats had a nerve-muscle pedicle (NMP) implanted into the left TA muscle 5 weeks after ST treatment. At 15 weeks, reinnervation was assessed by histologic evaluation of the TA muscle and by electromyography with stimulation of the RLNs and ACNs.
   Results: The muscle area, the number of nerve terminals, the number Of acetylcholine receptors, and the ratio of nerve terminals to acetylcholine receptors were significantly greater (p <0.05) in the NMP group than in the ST group. Electromyography elicited TA muscle compound action potentials upon stimulation of the RLNs and ACNs.
   Conclusions: In rats, NMP implantation is efficacious for reducing atrophic changes in the TA muscle in the presence of partial RLN innervation.
C1 [Aoyama, Takashi; Kumai, Yoshihiko; Yumoto, Eiji; Miyamaru, Satoru] Kumamoto Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, Kumamoto 8608556, Japan.
   [Ito, Takaaki] Kumamoto Univ, Sch Med, Dept Pathol & Expt Med, Kumamoto 8608556, Japan.
RP Kumai, Y (reprint author), Kumamoto Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, 1-1-1 Honjo, Kumamoto 8608556, Japan.
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NR 16
TC 3
Z9 3
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD DEC
PY 2010
VL 119
IS 12
BP 823
EP 829
PG 7
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 697CY
UT WOS:000285491400006
PM 21250554
ER

PT J
AU Hildebrand, MS
   Kahrizi, K
   Bromhead, CJ
   Shearer, AE
   Webster, JA
   Khodaei, H
   Abtahi, R
   Bazazzadegan, N
   Babanejad, M
   Nikzat, N
   Kimberling, WJ
   Stephan, D
   Huygen, PLM
   Bahlo, M
   Smith, RJH
   Najmabadi, H
AF Hildebrand, Michael S.
   Kahrizi, Kimia
   Bromhead, Catherine J.
   Shearer, A. Eliot
   Webster, Jennifer A.
   Khodaei, Hossein
   Abtahi, Rezvan
   Bazazzadegan, Niloofar
   Babanejad, Mojgan
   Nikzat, Nooshin
   Kimberling, William J.
   Stephan, Dietrich
   Huygen, Patrick L. M.
   Bahlo, Melanie
   Smith, Richard J. H.
   Najmabadi, Hossein
TI Mutations in TMC1 Are a Common Cause of DFNB7/11 Hearing Loss in the
   Iranian Population
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE deletion; DFNB7/11; splice site mutation; TMC1 gene
ID DOMINANT; DEAFNESS; DFNA36; IMPAIRMENT; LOCUS; MOUSE; GENE; MODEL; DNA
AB Objectives: We investigated the cause of autosomal recessive nonsyndromic hearing loss (ARNSHL) that segregated in 2 consanguineous Iranian families.
   Methods: Otologic and audiometric examinations were performed on affected members of each family. Genome-wide parametric multipoint linkage mapping using a recessive model was performed with Affymetrix 50K GeneChips or short tandem repeat polymorphisms. Direct sequencing was used to confirm the causative mutation in each family.
   Results: In 2 Iranian families, L-1651 and L-8600606, with ARNSHL that mapped to the DFNB7/11 locus, homozygosity for a reported splice site mutation (c.776+1G>A), and a novel deletion (c.1589_1590delCT; p.S530*) were identified in the TMC1 gene, respectively.
   Conclusions: Consistent with the previously reported phenotype in DFNB7/11 families, the 2 Iranian families had segregated congenital, profound hearing impairment. However, in family L-1651, one affected family member (IV:3) has milder hearing impairment than expected, suggesting a potential genetic modifier effect. These results indicate that DFNB7/11 is a common form of genetic hearing loss in Iran, because this population is the source of 6 of the 29 TMC1 mutations reported worldwide.
C1 [Hildebrand, Michael S.; Shearer, A. Eliot; Smith, Richard J. H.] Univ Iowa, Dept Otolaryngol Head & Neck Surg, Iowa City, IA 52242 USA.
   [Smith, Richard J. H.] Univ Iowa, Interdept PhD Program Genet, Iowa City, IA 52242 USA.
   [Webster, Jennifer A.; Stephan, Dietrich] Translat Genom Res Inst, Neurogenom Div, Phoenix, AZ USA.
   [Stephan, Dietrich] Arizona Alzheimers Consortium, Phoenix, AZ USA.
   [Stephan, Dietrich] Banner Alzheimers Inst, Phoenix, AZ USA.
   [Kimberling, William J.] Boys Town Natl Res Hosp, Dept Genet, Omaha, NE 68131 USA.
   [Kahrizi, Kimia; Bazazzadegan, Niloofar; Babanejad, Mojgan; Nikzat, Nooshin; Najmabadi, Hossein] Univ Social Welf & Rehabil Sci, Genet Res Ctr, Tehran, Iran.
   [Khodaei, Hossein] Yazd Welf Org, Yazd, Iran.
   [Abtahi, Rezvan] Omid Counseling Ctr, Saveh, Iran.
   [Bromhead, Catherine J.; Bahlo, Melanie] Walter & Eliza Hall Inst Med Res, Bioinformat Div, Melbourne, Australia.
   [Huygen, Patrick L. M.] Radboud Univ Nijmegen, Med Ctr, Dept Otorhinolaryngol, NL-6525 ED Nijmegen, Netherlands.
RP Smith, RJH (reprint author), Univ Iowa, Dept Otolaryngol Head & Neck Surg, 5270 CBRB Bldg, Iowa City, IA 52242 USA.
FU NIH NIDCD [R01 DC002842]; Iranian National Science Foundation
   [85033/10]; Australian National Health and Medical Research Council
   (NHMRC); NHMRC; Doris Duke Clinical Research Fellowship
FX Supported by NIH NIDCD grant R01 DC002842 (Smith), Iranian National
   Science Foundation Grant 85033/10 (Kahrizi), an Australian National
   Health and Medical Research Council (NHMRC) Career Development Award
   (Bahlo), an NHMRC Overseas Biomedical Postdoctoral Training Fellowship
   (Hildebrand), and a Doris Duke Clinical Research Fellowship (Shearer).
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NR 18
TC 11
Z9 11
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD DEC
PY 2010
VL 119
IS 12
BP 830
EP 835
PG 6
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 697CY
UT WOS:000285491400007
PM 21250555
ER

PT J
AU Tai, S
   Mascaro, M
   Goldstein, NA
AF Tai, Stephen
   Mascaro, Miguel
   Goldstein, Nira A.
TI Angioedema: A Review of 367 Episodes Presenting to Three Tertiary Care
   Hospitals
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT 113th Annual Meeting of the
   American-Academy-of-Otolaryngology-Head-and-Neck-Surgery-Foundation-and-
   OTO-EXPO
CY OCT 04-07, 2009
CL San Diego, CA
SP Amer Acad Otolaryngol Head & Neck Surg Fdn
DE airway obstruction; angioedema; angiotensin-converting enzyme inhibitor
ID INHIBITOR-INDUCED ANGIOEDEMA; CONVERTING ENZYME-INHIBITORS;
   CLINICAL-EXPERIENCE; AIRWAY; MULTICENTER; MANAGEMENT; RISK
AB Objectives: We evaluated the clinical characteristics of patients treated for angioedema, and determined the factors associated with the clinical course.
   Methods: We performed a chart review of 367 episodes presenting from 1997 through 2008.
   Results: The mean (+/- SD) age was 51.8 +/- 20.1 years; 65.7% of the episodes occurred in female patients; 62.4% of the episodes were in African American patients. The patients were on angiotensin-converting enzyme (ACE) inhibitors or angiotensin receptor blockers (ARBs) for 49.1% of the episodes, and an inciting factor (diet change, minor trauma, or exposure to fumes) was present for 21.5%. We found that 75.7% of the episodes were type I angioedema, 5.7% were type 2, 1.4% were type 3, and 17.2% involved multiple sites; 58% of the episodes required admission. For 3.3% of the episodes, the patients were intubated, and in 0.3% of the episodes, the patients required a tracheostomy. Logistic regression identified non African American race, allergies, alcohol use, use of ACE inhibitors or ARBs, multiple sites, and age as associated with the need for admission. Bivariate analysis identified age, multiple affected sites, stridor, hoarseness, dysphagia, and drooling as associated with intubation or tracheostomy.
   Conclusions: The novel findings of this study are lower rates of airway intervention than reported previously and the fact that multiple affected sites were associated with admission and intubation or tracheostomy, particularly when the edema involved the larynx or hypopharynx.
C1 [Tai, Stephen; Mascaro, Miguel; Goldstein, Nira A.] Suny Downstate Med Ctr, Dept Otolaryngol, Brooklyn, NY 11203 USA.
RP Goldstein, NA (reprint author), Suny Downstate Med Ctr, Dept Otolaryngol, 450 Clarkson Ave,Box 126, Brooklyn, NY 11203 USA.
CR Banerji A, 2008, ANN ALLERG ASTHMA IM, V100, P327, DOI 10.1016/S1081-1206(10)60594-7
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NR 18
TC 8
Z9 8
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD DEC
PY 2010
VL 119
IS 12
BP 836
EP 841
PG 6
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 697CY
UT WOS:000285491400008
PM 21250556
ER

PT J
AU Sawnani, H
   Murugappan, S
   Gutmark, E
   Donnelly, LF
   Amin, R
   Mylavarapu, G
   Mihaescu, M
   Khosla, S
   Kalra, M
AF Sawnani, Hemant
   Murugappan, Shanmugam
   Gutmark, Ephraim
   Donnelly, Lane F.
   Amin, Raouf
   Mylavarapu, Goutham
   Mihaescu, Mihai
   Khosla, Sid
   Kalra, Maninder
TI Influence of Gender on Pharyngeal Airway Length in Obese Adolescents
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE adolescent; computational fluid dynamics; gender; obesity; obstructive
   sleep apnea; pharynx
ID OBSTRUCTIVE SLEEP-APNEA; BREATHING DISORDERS; CHILDREN; POLYSOMNOGRAPHY;
   ASSOCIATIONS
AB Objectives: Although pharyngeal airway length has been implicated in an increased male predisposition for obstructive sleep apnea (USA) in adults, data in obese children and adolescents are lacking. Our objective was to determine the influence of gender on pharyngeal airway length in obese adolescents, and to apply computational simulations to better understand the effect of pharyngeal airway length on the airway's predisposition to collapse in this select group.
   Methods: Obese subjects without USA were recruited from our Sleep Center. Their pharyngeal airway length was measured on midline sagittal magnetic resonance images as the distance between the hard palate and the base of the epiglottis. Computational fluid dynamics analysis was used to study the effect of pharyngeal airway length on airflow characteristics. The gentler groups were compared for anthropometric measurements and pharyngeal airway length by an unpaired Student's t-test.
   Results: Our study group included 18 female and 16 male obese adolescents with a mean (+/- SD) age of 14.7 +/- 2.3 years and a mean body mass index of 38.9 +/- 6.9 kg/m(2). The groups did not differ in age, body weight, or normalized pharyngeal airway length (0.44 +/- 0.08 mm/cm in girls versus 0.44 +/- 0.11 mm/cm in boys; p = 0.9). The computational fluid dynamics simulation indicated that the 3-dimensional flow field and airway wall pressures were not significantly affected by pharyngeal airway lengthening of up to 10 mm.
   Conclusions: Our results indicate that in obese adolescents, there is no influence of gender on pharyngeal airway length, and pharyngeal airway length alone does not significantly affect the airway's predisposition to collapse. These findings suggest that pharyngeal airway length may not explain the increased male gender predisposition for USA in this select group.
C1 [Sawnani, Hemant; Amin, Raouf; Kalra, Maninder] Cincinnati Childrens Hosp, Med Ctr, Div Pulm Med, Cincinnati, OH 45029 USA.
   [Donnelly, Lane F.] Cincinnati Childrens Hosp, Med Ctr, Dept Radiol, Cincinnati, OH 45029 USA.
   [Murugappan, Shanmugam; Gutmark, Ephraim; Khosla, Sid] Univ Cincinnati, Coll Med, Dept Otolaryngol Head & Neck Surg, Cincinnati, OH USA.
   [Gutmark, Ephraim; Mylavarapu, Goutham; Mihaescu, Mihai] Univ Cincinnati, Dept Aerosp Engn & Engn Mech, Cincinnati, OH 45221 USA.
RP Sawnani, H (reprint author), Cincinnati Childrens Hosp, Med Ctr, Div Pulm Med, MLC 2021,3333 Burnet Ave, Cincinnati, OH 45029 USA.
RI Mihaescu, Mihai/F-5650-2010
OI Mihaescu, Mihai/0000-0001-7330-6965
FU American Academy of Sleep Medicine-Pfizer; Cincinnati Children's
   Research Foundation
FX Supported by an American Academy of Sleep Medicine-Pfizer Scholars Grant
   in Sleep Medicine and a Cincinnati Children's Research Foundation
   Trustee Grant, both to Dr Kalra.
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NR 23
TC 0
Z9 0
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD DEC
PY 2010
VL 119
IS 12
BP 842
EP 847
PG 6
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 697CY
UT WOS:000285491400009
PM 21250557
ER

PT J
AU Lorenz, KJ
   Grieser, L
   Ehrhart, T
   Maier, H
AF Lorenz, Kai J.
   Grieser, Laura
   Ehrhart, Theresa
   Maier, Heinz
TI Role of Reflux in Tracheoesophageal Fistula Problems After Laryngectomy
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE complication; pH monitoring; reflux; tracheoesophageal fistula; voice
   rehabilitation
ID INDWELLING VOICE PROSTHESES; GASTROESOPHAGEAL-REFLUX; LARYNGOPHARYNGEAL
   REFLUX; INJURY; REHABILITATION; MANAGEMENT; ACID; GERD
AB Objectives: The purpose of this 2-year prospective nonrandomized study was to investigate the relationship between pathological supraesophageal reflux and the occurrence of speech fistula complications, especially severe fistula enlargement, in patients who underwent total laryngectomy and prosthetic voice restoration.
   Methods: We objectively assessed the presence of reflux disease using 24-hour dual-probe pH monitoring in 60 laryngectomized patients, correlated the incidence of tracheoesophageal fistula complications with the severity of reflux, and assessed the risk of problems by determining the absolute number of reflux events at the level of the speech fistula, the reflux area index score, and the DeMeester score.
   Results: All patients with fistula enlargement showed highly pathological results in the diagnostic tests for reflux disease. Depending on reflux severity, the relative risk of developing fistula complications was up to 10 times higher for these patients.
   Conclusions: We found a significant correlation between the occurrence of tracheoesophageal fistula complications and the severity of supraesophageal reflux. Potential chronic irritation of the esophageal and tracheal mucosa can possibly contribute to the development of these problems. If the presence of reflux disease has been confirmed by 24-hour dual-probe pH monitoring, patients with fistula complications should be treated with proton pump inhibitors.
C1 [Lorenz, Kai J.; Grieser, Laura; Ehrhart, Theresa; Maier, Heinz] German Armed Forces Hosp, Dept Otorhinolaryngol Head & Neck Surg, D-89081 Ulm, Germany.
RP Lorenz, KJ (reprint author), German Armed Forces Hosp, Dept Otorhinolaryngol Head & Neck Surg, Oberer Eselsberg 40, D-89081 Ulm, Germany.
FU Atos Medical, Horby, Sweden; German Ministry of Defense
FX From the Department of Otorhinolaryngology-Head and Neck Surgery, German
   Armed Forces Hospital of Ulm, Ulm, Germany. Supported by Atos Medical,
   Horby, Sweden, and the German Ministry of Defense.
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NR 26
TC 11
Z9 12
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
EI 1943-572X
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD NOV
PY 2010
VL 119
IS 11
BP 719
EP 728
PG 10
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 685WV
UT WOS:000284659700001
PM 21140630
ER

PT J
AU Aguiar-Ricz, L
   Ricz, H
   de Mello, FV
   Perdona, GC
   Dantas, RO
AF Aguiar-Ricz, Lilian
   Ricz, Hilton
   de Mello-Filho, Francisco Verissimo
   Perdona, Gleici Castro
   Dantas, Roberto Oliveira
TI Intraluminal Esophageal Pressures in Speaking Laryngectomees
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE alaryngeal speech; manometry; total laryngectomy; tracheoesophageal
   prosthesis
ID VOICE RESTORATION; MOTILITY; SEGMENT; SPEECH; REHABILITATION; SPHINCTER
AB Objectives: The objective of the present study was to evaluate intraluminal esophageal pressure during voice and speech emission in speaking laryngectomees with a tracheoesophageal prosthesis.
   Methods: In our prospective analysis in a tertiary-care academic hospital, 25 laryngectomees were divided into 2 groups: 11 speaking individuals with a tracheoesophageal prosthesis and a control group of 14 nonspeaking laryngectomees. All patients were subjected to manometry during voice and speech emission tests. We determined the pressures achieved in the distal, middle, and proximal parts of the esophagus.
   Results: Statistical analysis revealed that the amplitude of pressure in the distal esophagus during sound emission was higher in speaking laryngectomees; in the middle esophagus, intraluminal pressure during emission of the sentence was higher in speaking subjects, and in the proximal esophagus there was no difference between the groups.
   Conclusions: During the manometric evaluation of the distal and middle esophagus in the presence of voice and speech emission, the intraluminal pressure revealed a significant difference for the speaking laryngectomees with a tracheoesophageal prosthesis. The proximal esophagus behaved similarly in the groups of speakers and nonspeakers. Speaking laryngectomees with a tracheoesophageal prosthesis depend on a differentiated performance of the middle and distal parts of the esophagus.
C1 [Aguiar-Ricz, Lilian; Ricz, Hilton; de Mello-Filho, Francisco Verissimo] Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Ophthalmol Otorhinolaryngol & Head & Neck Su, BR-14048900 Ribeirao Preto, SP, Brazil.
   [Perdona, Gleici Castro] Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Social & Prevent Med, BR-14048900 Ribeirao Preto, SP, Brazil.
   [Dantas, Roberto Oliveira] Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Internal Med, BR-14048900 Ribeirao Preto, SP, Brazil.
RP Ricz, H (reprint author), Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Ophthalmol Otorhinolaryngol & Head & Neck Su, Av Bandeirantes 3900, BR-14048900 Ribeirao Preto, SP, Brazil.
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NR 18
TC 3
Z9 4
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD NOV
PY 2010
VL 119
IS 11
BP 729
EP 735
PG 7
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 685WV
UT WOS:000284659700002
PM 21140631
ER

PT J
AU Bloom, JD
   Bleier, BS
   Mirza, N
   Chalian, AA
   Thaler, ER
AF Bloom, Jason D.
   Bleier, Benjamin S.
   Mirza, Natasha
   Chalian, Ara A.
   Thaler, Erica R.
TI Factors Predicting Endoscopic Exposure of Zenker's Diverticulum
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE endoscopic diverticulotomy; esophageal diverticulum; Zenker's
   diverticulum
ID PHARYNGEAL POUCH; ESOPHAGODIVERTICULOSTOMY
AB Objectives: The objectives of this study were 1) to understand which anatomic variables are associated with failed endoscopic exposure of Zenker's diverticulum and 2) to enable preoperative selection of patients suitable for endoscopic repair of Zenker's diverticulum on the basis of anatomic variables.
   Methods: We performed a prospective, Institutional Review Board approved study of 30 patients undergoing attempted endoscopic repair of Zenker's diverticulum. Three categorical variables (sex, presence of maxillary dentition, and Mallampati score) and 6 continuous variables (age, neck circumference, hyomental distance, neck length, neck extension, and body mass index [BMI]) were collected before operation and then correlated to successful endoscopic exposure of the Zenker's pouch by use of a Fisher's exact test and Student's t-test, respectively.
   Results: Exposure was unsuccessful in 9 of 30 patients (30%). Factors that correlated significantly with exposure failure included a shorter neck length (7.2 +/- 1.2 cm; p = 0.047), a shorter hyomental distance (5.0 +/- 1.1 cm; p = 0.004), and a higher BMI (27.2 +/- 4.0 kg/m(2); p = 0.05). The presence of maxillary dentition did not reach significance in exposure failure, but did show a trend toward an association.
   Conclusions: Surgical exposure in endoscopic repair of Zenker's diverticulum tends to be significantly less successful in patients with short necks, decreased hyomental distance, and/or a high BMI. An open approach should be considered in this patient population.
C1 [Bloom, Jason D.; Bleier, Benjamin S.; Mirza, Natasha; Chalian, Ara A.; Thaler, Erica R.] Univ Penn, Sch Med, Dept Otorhinolaryngol Head & Neck Surg, Philadelphia, PA 19104 USA.
RP Bloom, JD (reprint author), 3400 Spruce St,5 Silverstein Bldg, Philadelphia, PA 19104 USA.
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   RESOULY A, 1998, PHARYNGEAL POUCH SUR
   Sen P, 2004, J LARYNGOL OTOL, V118, P601
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NR 14
TC 9
Z9 9
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD NOV
PY 2010
VL 119
IS 11
BP 736
EP 741
PG 6
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 685WV
UT WOS:000284659700003
PM 21140632
ER

PT J
AU Woodson, G
AF Woodson, Gayle
TI Arytenoid Abduction: Indications and Limitations
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE arytenoid cartilage; bilateral laryngeal paralysis; surgery
ID LARYNGEAL RE-INNERVATION; VOCAL FOLD IMMOBILITY; LASER ARYTENOIDECTOMY;
   CORD PARALYSIS; REINNERVATION; CONFIGURATION; MANAGEMENT; CORDECTOMY;
   ADDUCTION; OPERATION
AB Objectives: I report further experience with arytenoid abduction (AAb), a procedure that enlarges the glottis by external rotation of the arytenoid cartilage and thus moves the vocal process laterally and rostrally, but does not preclude adduction for phonation. Therefore. AAb has the potential to preserve voice in patients with bilateral abductor laryngeal paralysis.
   Methods: I performed a retrospective review of AAb in 11 patients with bilateral laryngeal paralysis and 3 patients with other neurologic causes of glottal airway compromise, ie, adductor breathing dystonia, frequent laryngospasm, and progressive laryngeal breathing dysfunction.
   Results: Seven of the 11 patients with bilateral paralysis had dramatic airway improvement. One patient required a tracheotomy after AAb, and 3 patients with an existing tracheotomy could not be decannulated. Arytenoid abduction relieved airway obstruction in the patient with recurrent laryngospasm and in the child with progressive laryngeal breathing dysfunction, but the patient with adductor breathing dystonia has persistent stridor. The factors associated with a poor airway outcome included prolonged tracheotomy, electromyographic evidence of inspiratory activity of adductor muscles, chronic obstructive pulmonary disease, sleep apnea, and prior cordotomy or arytenoidectomy.
   Conclusions: Arytenoid abduction is most effective in patients with bilateral laryngeal paralysis of less than 1 year's duration who do not have unfavorable laryngeal adductor activity.
C1 So Illinois Univ, Sch Med, Div Otolaryngol, Springfield, IL 62794 USA.
RP Woodson, G (reprint author), So Illinois Univ, Sch Med, Div Otolaryngol, Springfield, IL 62794 USA.
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NR 26
TC 4
Z9 4
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD NOV
PY 2010
VL 119
IS 11
BP 742
EP 748
PG 7
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 685WV
UT WOS:000284659700004
PM 21140633
ER

PT J
AU Ikeda, K
   Yokoi, H
   Kusunoki, T
   Saitoh, T
   Yao, T
   Kase, K
   Minekawa, A
   Inoshita, A
   Kawano, K
AF Ikeda, Katsuhisa
   Yokoi, Hidenori
   Kusunoki, Takeshi
   Saitoh, Tatuya
   Yao, Toru
   Kase, Kaori
   Minekawa, Akira
   Inoshita, Ayako
   Kawano, Kenji
TI Relationship Between Olfactory Acuity and Peak Expiratory Flow During
   Postoperative Follow-Up in Chronic Rhinosinusitis Associated With Asthma
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE asthma; chronic rhinosinusitis; endoscopic sinus surgery; peak
   expiratory flow; self smell test
ID ENDOSCOPIC SINUS SURGERY; ALLERGIC RHINITIS; NASAL POLYPS; INFECTIONS;
   RESPONSIVENESS; ASPIRATION; FEATURES; DISEASE
AB Objectives: The link between nasal and bronchial disease has been studied extensively for chronic rhinosinusitis and asthma. The concept of "united airway allergy" has become widely accepted in the past decade. We evaluated the relationship between the upper and lower airways during follow-up after endoscopic sinus surgery by monitoring sinonasal and pulmonary functions.
   Methods: Thirty-nine subjects with chronic rhinosinusitis associated with bronchial asthma were entered in this study. A self smell test using stick-type odorant materials was carried out daily to evaluate postoperative recurrence of sinonasal disease. Each patient was assessed for peak expiratory flow (PEP) 3 times daily.
   Results: The average (+/- SD) scores of initial symptoms were 8.3 +/- 2.2, which was significantly decreased to 1.5 +/- 1.4 by 3 months after operation. During postoperative follow-up, 25 of 39 patients showed no decrease in PEF, whereas the other 14 patients had at least 1 episode of a significant decline in PEP. In the postoperative course, with respect to the self smell test, 24 patients showed no aggravation of smell, but 15 patients had episode(s) of decreased olfaction. Twelve patients demonstrated worsening on the smell test concomitant with a decreased PEF. A discrepancy between olfactory acuity and pulmonary function was recognized in 5 patients. There were 22 patients with a good prognosis of parameters of both the upper and lower airways.
   Conclusions: Daily monitoring of both upper and lower respiratory tract functions clearly revealed dual relationships, indicating that worsening of sinusitis accompanies asthma exacerbation. Appropriate measures of the upper and lower airways following endoscopic sinus surgery can be used to predict patient outcome.
C1 [Ikeda, Katsuhisa] Juntendo Univ, Sch Med, Dept Otorhinolaryngol, Fac Med,Bunkyo Ku, Tokyo 1138421, Japan.
RP Ikeda, K (reprint author), Juntendo Univ, Sch Med, Dept Otorhinolaryngol, Fac Med,Bunkyo Ku, 2-1-1 Hongo, Tokyo 1138421, Japan.
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NR 44
TC 1
Z9 1
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD NOV
PY 2010
VL 119
IS 11
BP 749
EP 754
PG 6
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 685WV
UT WOS:000284659700005
PM 21140634
ER

PT J
AU Gustavii, N
   Bove, M
   Dahlin, C
AF Gustavii, Nils
   Bove, Mogens
   Dahlin, Christer
TI Postoperative Morbidity in Traditional Versus Coblation Tonsillectomy
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE Coblation; randomization; tonsillectomy
ID RANDOMIZED CONTROLLED-TRIAL; DISSECTION TONSILLECTOMY; DOUBLE-BLIND;
   PAIN; HEMOSTASIS; HEMORRHAGE
AB Objectives: The aim of this study was to compare levels of postoperative pain after traditional (cold steel with bipolar cautery) and Coblation tonsillectomies.
   Methods: Patients with recurrent or chronic tonsillitis, including tonsillar hyperplasia, were randomized to undergo tonsillectomies using either a traditional cutting technique or the Coblation technique. Patients and staff on the relevant wards were blinded regarding patient allocation. Pain, odynophagia, and activity limitations were recorded on a visual analog scale. Analgesics were self-administered, and daily analgesic consumption by patients was reported. All complications were also registered.
   Results: Fifty-seven patients (between 6 and 57 years of age) completed the study. No significant difference was found between the two techniques with regard to reported pain, odynophagia, activity limitations, or use of analgesics. A slight tendency toward decreased pain and decreased use of analgesics in the Coblation group reached statistical significance only when the adult patients were analyzed separately. Two cases of hospital readmission occurred because of postoperative bleeding following Coblation tonsillectomies.
   Conclusions: Overall, the two methods are equivalent in terms of postoperative pain, including the use of analgesics. The risk of postoperative bleeding after the Coblation method requires further evaluation with specifically designed studies.
C1 [Gustavii, Nils; Bove, Mogens; Dahlin, Christer] N Alvsborg Cty Hosp, Dept Otorhinolaryngol & Oral Maxillofacial Surg, Trollhattan, Sweden.
   [Dahlin, Christer] Univ Gothenburg, Sahlgrenska Acad, Inst Clin Sci, Dept Biomat Sci, Gothenburg, Sweden.
RP Bove, M (reprint author), N Alvsborg Cty Hosp, Dept Otorhinolaryngol & Oral Maxillofacial Surg, Trollhattan, Sweden.
FU Fyrbodal Research and Development Council
FX From the Department of Otorhinolaryngology and Oral Maxillofacial
   Surgery, North Alvsborg County Hospital, Trollhattan (all authors), and
   the Department of Biomaterials Science, Institute for Clinical Sciences,
   Sahlgrenska Academy, University of Gothenburg, Gothenburg (Dahlin),
   Sweden. This work was supported by a grant from the Fyrbodal Research
   and Development Council.
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NR 13
TC 1
Z9 1
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD NOV
PY 2010
VL 119
IS 11
BP 755
EP 760
PG 6
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 685WV
UT WOS:000284659700006
PM 21140635
ER

PT J
AU Thomeer, HGXM
   Kunst, HPM
   Cremers, CWRJ
AF Thomeer, Henricus G. X. M.
   Kunst, Henricus P. M.
   Cremers, Cor W. R. J.
TI Isolated Congenital Stapes Ankylosis: Surgical Results in a Consecutive
   Series of 39 Ears
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE branchio-oto-renal syndrome; congenital hearing loss; Klippel-Feil
   syndrome; stapedectomy; stapedotomy; stapes ankylosis; stapes gusher;
   Stickler syndrome; Teunissen-Cremers syndrome; Treacher Collins syndrome
ID UNILATERAL HEARING-LOSS; OSSICULAR ANOMALIES; DEAFNESS SYNDROME;
   MALFORMATIONS; STAPEDECTOMY; FIXATION; CHILDREN; FOOTPLATE; BONE
AB Objectives: We describe the audiometric results after stapes surgery in a consecutive series of patients with isolated stapes footplate ankylosis.
   Methods: We performed a retrospective analysis of charts from 1986 to 2001 in a tertiary referral center, focusing on audiometric results.
   Results: A total of 28 patients (39 ears) underwent stapedotomy or stapedectomy, and 5 patients (5 ears) had a syndromal diagnosis. Overall, we observed a mean gain in air conduction threshold of 21 dB (from 46 to 25 dB) and a mean postoperative air-bone gap of 14 dB (mean preoperative air bone gap, 36 dB). The postoperative air-bone gap was 10 dB or less in 46% of cases, in agreement with results reported in the literature. Moreover, the audiometric results remained stable. In the group of ears with a syndrome, the mean gain in air conduction threshold was only 12 dB (range, -13.8 to 32.5 dB), which was a worse outcome than that in the nonsyndromic ears.
   Conclusions: Surgery for isolated congenital stapes footplate ankylosis provides satisfactory audiometric outcomes. The postoperative air-bone gap was 10 dB or less in 18 of the 39 ears (46%) and 20 dB or less in 29 of the 39 ears (74%). Most ears had some sensorineural impairment (10 to 20 dB), which influenced the final hearing level after surgery. Preoperative assessment is mandatory to search for syndromal diagnoses, which might be important for patient counseling and prognosis.
C1 [Thomeer, Henricus G. X. M.] Radboud Univ Nijmegen, Med Ctr, Dept Otorhinolaryngol, Donders Inst Neurosci, NL-6500 HB Nijmegen, Netherlands.
   Radboud Univ Nijmegen, Med Ctr, Donders Ctr Brain Cognit & Behav, NL-6500 HB Nijmegen, Netherlands.
RP Thomeer, HGXM (reprint author), Radboud Univ Nijmegen, Med Ctr, Dept Otorhinolaryngol, Donders Inst Neurosci, POB 9101, NL-6500 HB Nijmegen, Netherlands.
RI Kunst, Henricus/J-6456-2012
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NR 39
TC 3
Z9 3
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD NOV
PY 2010
VL 119
IS 11
BP 761
EP 766
PG 6
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 685WV
UT WOS:000284659700007
PM 21140636
ER

PT J
AU Xu, W
   Wang, L
   Zhang, L
   Han, DM
   Zhang, L
AF Xu, Wen
   Wang, Lei
   Zhang, Li
   Han, Demin
   Zhang, Luo
TI Otolaryngological Manifestations and Genetic Characteristics of Lipoid
   Proteinosis
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE ECM1; hoarseness; larynx; lipoid proteinosis; pharynx; skin
ID MUCOSAE; LARYNX; CUTIS
AB Objectives: We investigated the otolaryngological manifestations and genetic characteristics of lipoid proteinosis (LP).
   Methods: Twenty-two cases of LP were included. Multisystem manifestations, pharyngolaryngeal behaviors, and histopathologic and genetic characteristics were evaluated.
   Results: All patients presented with hoarseness as the first sign. The onset was in the newborn period in 14 cases. Video-laryngoscopy revealed irregularities along the edges and the surface of the vocal folds with diffuse yellowish deposits. In 18 cases, the oral and pharyngeal mucosa showed yellow-white infiltrates. In all cases, whitish moniliform papules were observed on the upper eyelids. In 18 cases, pocklike scars were present on the face and limbs. Histologically, there were diffuse depositions of hyaline material in the submucosa and dermis that were positive on periodic acid Schiff staining and negative on Congo red staining. Two patients had homozygous mutations in ECM1 exon 6 and exon 8, and 13 patients had heterozygous mutations in ECM1 exons. Nine patients underwent microlaryngosurgery for excision of deposits in the vocal folds. The voice function was significantly improved after operation.
   Conclusions: Persistent hoarseness from early infancy with laryngeal involvement is the most common feature of LP. Histopathologic characteristics and skin and mucosa changes aid in the diagnosis. Microlaryngosurgery may improve the voice function. Compound heterozygote mutations may be frequent in LP in nonconsanguineous Chinese families.
C1 [Xu, Wen; Wang, Lei; Zhang, Li; Han, Demin; Zhang, Luo] Capital Med Univ, Beijing Tongren Hosp, Dept Otorhinolaryngol Head & Neck Surg, Beijing 100730, Peoples R China.
RP Han, DM (reprint author), Capital Med Univ, Beijing Tongren Hosp, Dept Otorhinolaryngol Head & Neck Surg, 1 Dongjiaominxiang, Beijing 100730, Peoples R China.
CR Acar A, 2004, INT J PEDIATR OTORHI, V68, P1557, DOI 10.1016/j.ijporl.2004.07.012
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   HOFER PA, 1974, ACTA PATH MICRO IM A, VA 82, P547
   Kaya TI, 2002, PEDIATR DERMATOL, V19, P359, DOI 10.1046/j.1525-1470.2002.00104.x
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   Wang CY, 2006, BRIT J DERMATOL, V155, P470, DOI 10.1111/j.1365-2133.2006.07292.x
NR 11
TC 4
Z9 4
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD NOV
PY 2010
VL 119
IS 11
BP 767
EP 771
PG 5
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 685WV
UT WOS:000284659700008
PM 21140637
ER

PT J
AU Wie, OB
   Pripp, AH
   Tvete, O
AF Wie, Ona B.
   Pripp, Are Hugo
   Tvete, Ole
TI Unilateral Deafness in Adults: Effects on Communication and Social
   Interaction
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE auditory rehabilitation; quality of life; self-rated hearing difficulty;
   speech perception; unilateral deafness
ID REPORTED HEARING DIFFICULTIES; ACOUSTIC NEUROMA SURGERY;
   QUALITY-OF-LIFE; SPEECH-PERCEPTION; CHILDREN; DISABILITIES; IMPAIRMENTS;
   NOISE
AB Objectives: The aim of this study was to explore the self-reported consequences of profound unilateral deafness regarding communication and social interaction and to compare subjects' speech perception scores to those of normal-hearing. individuals who were rendered temporarily unilaterally deaf.
   Methods: Cross-sectional data from 30 individuals with unilateral deafness and 30 individuals with normal hearing (age, 14 to 75 years) were obtained through structured interviews and tests of audiovisual, auditory-only, and visual-only speech perception.
   Results: In individuals with permanent unilateral deafness, 93% reported that hearing loss affected communication. Eighty-seven percent reported problems with speech perception in noisy settings. Other consequences were feelings of exclusion, reduced well-being, and extensive use of speech perception strategies. Inducing temporary unilateral deafness (through short-term blocking of one ear) in normal-hearing subjects produced similar effects on speech perception (27% score) as those experienced by unilaterally deaf subjects (25% score).
   Conclusions: Individuals with unilateral deafness experienced a significant disability in auditory function that affected their communication and social interaction. The major challenges were communicating in situations with background noise, in poor acoustic surroundings, and with limited access to speech-reading or direct listening. Under certain listening conditions, long-standing unilateral deafness seemed to yield no advantage over temporary deafness on one side.
C1 [Wie, Ona B.; Tvete, Ole] Oslo Univ Hosp, Rikshosp, Dept Otolaryngol, N-0027 Oslo, Norway.
   [Pripp, Are Hugo] Oslo Univ Hosp, Rikshosp, Biostat & Epidemiol Unit, N-0027 Oslo, Norway.
RP Wie, OB (reprint author), Oslo Univ Hosp, Rikshosp, Dept Otolaryngol, N-0027 Oslo, Norway.
CR Andersson G, 1997, AM J OTOL, V18, P421
   Arnold P, 2001, BRIT J PSYCHOL, V92, P339, DOI 10.1348/000712601162220
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   De Jonge Robert, 1994, P180
   DODD B, 1977, PERCEPTION, V6, P31, DOI 10.1068/p060031
   English K, 1999, LANG SPEECH HEAR SER, V30, P26
   Hallberg LRM, 2008, DISABIL REHABIL, V30, P203, DOI 10.1080/09638280701228073
   HANSSON H, 1993, THESIS U STOCKHOLM S
   Kramer SE, 1998, AUDIOLOGY, V37, P302
   Lieu JEC, 2004, ARCH OTOLARYNGOL, V130, P524, DOI 10.1001/archotol.130.5.524
   Linstrom CJ, 2009, LARYNGOSCOPE, V119, P713, DOI 10.1002/lary.20164
   Markides A, 1977, BINAURAL HEARING AID, P276
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   Ruscetta MN, 2005, INT J PEDIATR OTORHI, V69, P771, DOI 10.1016/j.ijporl.2005.01.010
   Stach BA, 2010, CLIN AUDIOLOGY INTRO
   TEIG E, 1993, ADV OTO-RHINO-LARYNG, V48, P199
   Tharpe Anne Marie, 2008, Trends Amplif, V12, P7, DOI 10.1177/1084713807304668
   Tyler R.S., 1987, IOWA AUDIOVISUAL SPE
   Valente M, 2002, STRATEGIES SELECTING, P253
   Vermeire K, 2009, AUDIOL NEURO-OTOL, V14, P163, DOI 10.1159/000171478
   Welsh LW, 2004, ANN OTO RHINOL LARYN, V113, P987
   Woodhouse L, 2009, INT J LANG COMM DIS, V44, P253, DOI 10.1080/13682820802090281
NR 27
TC 17
Z9 17
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD NOV
PY 2010
VL 119
IS 11
BP 772
EP 781
PG 10
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 685WV
UT WOS:000284659700009
PM 21140638
ER

PT J
AU Cheng, AY
   Soliman, AMS
AF Cheng, Alex Y.
   Soliman, Ahmed M. S.
TI Use of a Microdebrider for Subepithelial Excision of Benign Vocal Fold
   Lesions
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE benign lesion; microdebrider; surgical treatment; vocal fold lesion
ID LARYNGEAL; SURGERY
AB Objectives: We present a series of patients who underwent excision of subepithelial lesions using a laryngeal microdebrider.
   Methods: A retrospective review was carried out of all patients who between June 2005 and April 2009 underwent microlaryngoscopy and excision of vocal fold lesions by the senior author using a microdebrider. The patients' demographics, past medical history, preoperative and postoperative videostroboscopy findings, and surgical pathology findings were reviewed.
   Results: Eight patients were identified. All were female and had a mean age of 44 years (range, 21 to 54 years). Four patients had a unilateral pseudocyst, 2 patients had bilateral pseudocysts, 1 patient had bilateral Reinke's edema, and I patient had unilateral Reinke's edema. Through an incision made just lateral to the lesion on the superior surface, a small microdebrider blade was inserted and run at 800 to 1,000 revolutions per minute in oscillation mode with low wall suction until the lesion was completely excised, and the overlying, epithelium was left intact. Postoperative videostroboscopic examination of the larynx revealed an absence of lesions and near-complete glottal closure in all patients. Seven of the 8 patients reported an improvement in voice.
   Conclusions: Microdebrider excision of subepithelial vocal fold lesions is feasible. The patients with Reinke's edema had slightly more residual edema, a decreased epithelial wave, and less improvement in voice as compared to the patients with pseudocysts. Meticulous technique, low oscillation speeds, and low wall suction are necessary to avoid injury to the overlying epithelium.
C1 [Cheng, Alex Y.; Soliman, Ahmed M. S.] Temple Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, Philadelphia, PA 19140 USA.
RP Soliman, AMS (reprint author), Temple Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, 3400 N Broad St,Kresge W 102, Philadelphia, PA 19140 USA.
CR Flint PW, 2000, OTOLARYNG HEAD NECK, V122, P263, DOI 10.1016/S0194-5998(00)70251-8
   Honda K, 2010, ANN OTO RHINOL LARYN, V119, P32
   Mortensen M, 2009, LARYNGOSCOPE, V119, P1848, DOI 10.1002/lary.20563
   Myer CM, 1999, LARYNGOSCOPE, V109, P1165, DOI 10.1097/00005537-199907000-00030
   Nuyens M, 2006, ACTA OTO-LARYNGOL, V126, P402, DOI 10.1080/00016480500390246
   Patel RS, 2000, CLIN OTOLARYNGOL, V25, P358, DOI 10.1046/j.1365-2273.2000.00389.x
   Rees CJ, 2005, OTOLARYNG HEAD NECK, V133, P509, DOI 10.1016/j.otohns.2005.06.029
   SANTANNA GD, 2000, LARYNGOSCOPE, V110, P2214
   Setliff R C 3rd, 1996, Otolaryngol Clin North Am, V29, P95
NR 9
TC 3
Z9 3
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD NOV
PY 2010
VL 119
IS 11
BP 782
EP 785
PG 4
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 685WV
UT WOS:000284659700010
PM 21140639
ER

PT J
AU Sepehr, A
   Karam, AM
   Wong, BJF
AF Sepehr, Ali
   Karam, Amir M.
   Wong, Brian J. F.
TI Novel Endoscopic Management of Penetrating Intracranial Trauma
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE endoscopic surgery; eye injury; head injury; orbitocranial foreign body;
   penetrating injury
ID NAIL-GUN; INJURY
AB We report a unique case of minimally invasive endoscopic removal of a penetrating orbitocranial foreign body (POCFB), and present a review of the literature. A 12-year-old boy was impaled in the orbit with a gate latch. Neurosurgical consultation ascertained that removal via bifrontal craniotomy would necessitate extensive brain retraction and result in permanent anosmia. Attempting nasal endoscopic removal was deemed prudent, given this morbidity and a lack of brain parenchymal violation. The patient recovered without a cerebrospinal fluid leak or other neurologic sequelae. To date, craniotomy is the only reported management of POCFBs in the literature. We herein report the first nasal endoscopic removal of a POCFB.
C1 [Sepehr, Ali; Karam, Amir M.; Wong, Brian J. F.] Univ Calif Irvine, Sch Med, Dept Otolaryngol Head & Neck Surg, Orange, CA 92668 USA.
RP Wong, BJF (reprint author), Univ Calif Med Ctr, Bldg 56,Suite 500,Rt 81,101 City Dr, Orange, CA 92868 USA.
CR Bock H, 2002, INT J LEGAL MED, V116, P279, DOI 10.1007/s00414-001-0281-8
   de Andrade AF, 2006, J NEUROSURG, V104, P853, DOI 10.3171/jns.2006.104.5.853
   Kim S, 2005, ACTA OPHTHALMOL SCAN, V83, P609, DOI 10.1111/j.1600-0420.2005.00528.x
   Litvack ZN, 2006, J NEUROSURG, V104, P828, DOI 10.3171/jns.2006.104.5.828
   Olasoji HO, 2005, BRIT J ORAL MAX SURG, V43, P329, DOI 10.1016/j.bjoms.2004.10.026
NR 5
TC 0
Z9 0
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD NOV
PY 2010
VL 119
IS 11
BP 786
EP 788
PG 3
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 685WV
UT WOS:000284659700011
PM 21140640
ER

PT J
AU Nuss, RC
   Ward, J
   Huang, L
   Volk, M
   Woodnorth, GH
AF Nuss, Roger C.
   Ward, Jessica
   Huang, Lin
   Volk, Mark
   Woodnorth, Geralyn Harvey
TI Correlation of Vocal Fold Nodule Size in Children and Perceptual
   Assessment of Voice Quality
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE CAPE-V scale; child; vocal fold nodule; voice quality
ID ACOUSTIC ANALYSIS; DISORDERS
AB Objectives: We examined the relationship between the size of vocal fold nodules and perceptual rating of voice quality in children.
   Methods: We carried out an Institutional Review Board approved retrospective study in a voice clinic within a tertiary-care pediatric medical center. We studied children seen between 2000 and 2009 with a primary diagnosis of vocal fold nodules as the cause of their voice disturbance. Pediatric vocal fold nodule size was rated with a published validated scale, and voice quality was rated on the Consensus Auditory-Perceptual Evaluation of Voice scale.
   Results: One hundred forty-five patients met the inclusion criteria. Small nodules were noted in 23% of patients, medium nodules in 39%, and large nodules in 37%. Univariate and multivariate analyses demonstrated a statistically significant relationship (p < 0.05) between vocal fold nodule size and rated perceptual qualities of overall severity of voice disturbance, roughness, strain, pitch, and loudness. With the exception of loudness, as vocal fold nodule size increased, the mean value of perceptual characteristics became larger. The age of the patient was a significant factor associated with the overall severity of the voice disturbance and roughness.
   Conclusions: The overall severity of a child's voice disturbance and qualities of roughness, strain, pitch, and loudness have a strong correlational relationship with pediatric vocal fold nodule size, which is suggestive of causality.
C1 [Nuss, Roger C.; Ward, Jessica; Volk, Mark; Woodnorth, Geralyn Harvey] Childrens Hosp, Dept Otolaryngol & Commun Enhancement, Boston, MA 02115 USA.
   [Huang, Lin] Childrens Hosp, Clin Res Program, Boston, MA 02115 USA.
   [Nuss, Roger C.; Ward, Jessica; Volk, Mark; Woodnorth, Geralyn Harvey] Harvard Univ, Sch Med, Dept Otol & Laryngol, Boston, MA 02115 USA.
RP Nuss, RC (reprint author), Childrens Hosp, Dept Otolaryngol & Commun Enhancement, 300 Longwood Ave, Boston, MA 02115 USA.
CR De Bodt MS, 2007, J VOICE, V21, P151, DOI 10.1016/j.jvoice.2005.11.006
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   Karnell MP, 2007, J VOICE, V21, P576, DOI 10.1016/j.jvoice.2006.05.001
   Kempster GB, 2009, AM J SPEECH-LANG PAT, V18, P124, DOI 10.1044/1058-0360(2008/08-0017)
   Kilic MA, 2004, INT J PEDIATR OTORHI, V68, P409, DOI 10.1016/j.ijporl.2003.11.005
   Lee L, 2004, LANG SPEECH HEAR SER, V35, P308, DOI 10.1044/0161-1461(2004/030)
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   Niedzielska G, 2001, INT J PEDIATR OTORHI, V60, P119, DOI 10.1016/S0165-5876(01)00506-7
   Shah RK, 2008, OTOLARYNG HEAD NECK, V139, P723, DOI 10.1016/j.otohns.2008.08.010
   Shah RK, 2007, OTOLARYNG HEAD NECK, V136, P193, DOI 10.1016/j.otohns.2006.11.003
   Shah RK, 2005, INT J PEDIATR OTORHI, V69, P903, DOI 10.1016/j.ijport.2005.01.029
NR 14
TC 3
Z9 4
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD OCT
PY 2010
VL 119
IS 10
BP 651
EP 655
PG 5
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 662YI
UT WOS:000282849800001
PM 21049848
ER

PT J
AU Choi, JH
   Kim, EJ
   Choi, J
   Kwon, SY
   Kim, TH
   Lee, SH
   Lee, HM
   Shin, C
   Lee, SH
AF Choi, Ji Ho
   Kim, Eun Joong
   Choi, June
   Kwon, Soon Young
   Kim, Tae Hoon
   Lee, Sang Hag
   Lee, Heung Man
   Shin, Chol
   Lee, Seung Hoon
TI Obstructive Sleep Apnea Syndrome: A Child Is Not Just a Small Adult
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE body mass index; child; obstructive sleep apnea syndrome; palatine
   tonsil; polysomnography; sign; symptom
ID PREVALENCE; INFANTS; HISTORY; OBESITY; AROUSAL
AB Objectives: Pediatric obstructive sleep apnea syndrome (OSAS), like adult OSAS, is characterized by intermittent upper airway collapse during sleep and is associated with anatomic and neuromuscular factors. However, the clinical manifestations, diagnostic criteria, and polysomnographic findings of OSAS in children are likely to be different from those in adults. The purpose of this study was to identify the characteristics that distinguish the clinical manifestations and polysomnographic findings of OSAS in children from those in adults.
   Methods: The study population consisted of 34 children (mean age, 7.6 years; range, 4 to 16 years) with OSAS and 33 adults (mean age, 40.1 years; range, 18 to 58 years) with OSAS. We compared various clinical manifestations, such as body mass index, tonsil size, severity of symptoms and signs, and polysomnographic data, between these groups.
   Results: Obesity was more common among the adults, whereas tonsillar hypertrophy was more common among the children. There were significant differences between the groups in the severity of symptoms and signs, including witnessed apnea, daytime sleepiness, morning headache, memory reduction, and daytime fatigue. In the children with OSAS, slow-wave sleep was relatively well preserved, and respiratory events such as apnea and hypopnea occurred mainly during rapid eye movement sleep.
   Conclusions: The clinical manifestations and polysomnographic findings in children with OSAS differ from those in adults with OSAS.
C1 [Choi, Ji Ho; Kim, Eun Joong; Choi, June; Kwon, Soon Young; Kim, Tae Hoon; Lee, Sang Hag; Lee, Heung Man; Lee, Seung Hoon] Korea Univ, Coll Med, Dept Otorhinolaryngol Head & Neck Surg, Seoul, South Korea.
   [Shin, Chol] Korea Univ, Coll Med, Dept Resp Internal Med, Seoul, South Korea.
RP Lee, SH (reprint author), Korea Univ, Ansan Hosp, Coll Med, Dept Otorhinolaryngol Head & Neck Surg, 516 Gojan Dong, Ansan 425707, Gyeonggi Do, South Korea.
EM shleeent@korea.ac.kr
RI Choi, June/E-7063-2013
FU Ministry for Health, Welfare and Family Affairs, Republic of Korea
   [A090084]
FX From the Departments of Otorhinolaryngology-Head and Neck Surgery (J. H.
   Choi, E. J. Kim, J. Choi, S. Y. Kwon, T. H. Kim, S. H. Lee, H. M. Lee,
   S. H. Lee) and Respiratory Internal Medicine (C. Shin), College of
   Medicine, Korea University, Seoul, Korea. This study was supported by a
   grant from the Korea Healthcare Technology R & D Project, Ministry for
   Health, Welfare and Family Affairs, Republic of Korea (A090084).
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NR 27
TC 6
Z9 6
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD OCT
PY 2010
VL 119
IS 10
BP 656
EP 661
PG 6
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 662YI
UT WOS:000282849800002
PM 21049849
ER

PT J
AU Watanabe, T
   Suzuki, M
AF Watanabe, Tetsuo
   Suzuki, Masashi
TI Bilateral Peritonsillar Abscesses: Our Experience and Clinical Features
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE bilaterality; C-reactive protein; deviated uvula; immediate
   tonsillectomy; peritonsillar abscess
ID QUINSY TONSILLECTOMY; AIRWAY-OBSTRUCTION
AB Objectives: This study analyzed the incidence and characteristics of bilateral peritonsillar abscesses (PTAs) that were treated with immediate tonsillectomy.
   Methods: The study analyzed 409 patients with PTAs treated between 1984 and 2008. The patients included 304 male and 105 female patients between 2 and 85 years of age (median age, 30 years). Immediate tonsillectomy was performed in 371 of the PTA patients (90.7%). The incidence of bilateral PTAs and candidate predictive factors for bilateral PTAs were reviewed, including age, duration of PTA symptoms, history of recurrent tonsillitis, history of PTAs, deviation of the uvula, body temperature on admission, white blood cell count on admission, and C-reactive protein level on admission.
   Results: Bilateral PTAs were found in 24 of 371 patients (6.5%). Younger age, absence of a deviated uvula, and a higher C-reactive protein value were the clinical features associated with bilateral PTAs in multivariate analysis.
   Conclusions: The occurrence of bilateral PTAs was not rare; this fact has to be taken into consideration in discussing therapeutic concepts. The clinical features of bilateral PTAs suggested that bilateral PTAs might be a part of the natural history of PTAs, and that they occur in cases in which there is a delay in diagnosis and treatment. Further study is necessary to confirm the causation of bilateral PTAs.
C1 [Watanabe, Tetsuo; Suzuki, Masashi] Oita Univ, Fac Med, Dept Otolaryngol, Yufu City, Oita 8795593, Japan.
RP Watanabe, T (reprint author), Oita Univ, Fac Med, Dept Otolaryngol, 1-1 Idaigoka, Yufu City, Oita 8795593, Japan.
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NR 17
TC 1
Z9 2
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD OCT
PY 2010
VL 119
IS 10
BP 662
EP 666
PG 5
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 662YI
UT WOS:000282849800003
PM 21049850
ER

PT J
AU Mayerhoff, RM
   Pitman, MJ
AF Mayerhoff, Ross M.
   Pitman, Michael J.
TI Atypical and Disparate Presentations of Laryngeal Sarcoidosis
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE dysphagia; dysphonia; granuloma; larynx; sarcoidosis; upper airway
ID INVOLVEMENT
AB Sarcoidosis is a multisystem chronic granulomatous disease of unknown cause that typically affects patients between 20 and 40 years of age. Laryngeal involvement most frequently involves the supraglottis and presents with dyspnea. We present a retrospective review of 4 patients with previously undiagnosed sarcoidosis who presented with atypical signs and symptoms of sarcoidosis: dysphonia with isolated vocal fold involvement; cough and globus pharyngeus; pediatric sarcoidosis; and severe bilateral vocal fold paresis and dysphagia. Our aim is to highlight disparate presentations of laryngeal sarcoidosis, as well as the treatment options. Laryngeal sarcoidosis may present with atypical signs and symptoms and occasionally presents in pediatric patients. A high degree of suspicion is necessary for a correct diagnosis in these patients. Early diagnosis and proper management of laryngeal sarcoidosis is important, as the symptoms are debilitating and possibly life-threatening. Treatment may consist of local and systemic chemotherapy, and adjunctive procedures.
C1 [Pitman, Michael J.] New York Eye & Ear Infirm, Dept Otolaryngol, New York, NY 10003 USA.
   [Mayerhoff, Ross M.] SUNY Stony Brook, Sch Med, Stony Brook, NY 11794 USA.
RP Pitman, MJ (reprint author), New York Eye & Ear Infirm, Dept Otolaryngol, 310 E 14th St, New York, NY 10003 USA.
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NR 14
TC 5
Z9 5
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD OCT
PY 2010
VL 119
IS 10
BP 667
EP 671
PG 5
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 662YI
UT WOS:000282849800004
PM 21049851
ER

PT J
AU Dawes, PJD
   Welch, D
AF Dawes, Patrick J. D.
   Welch, David
TI Childhood Hearing and Its Relationship With Tinnitus at Thirty-Two Years
   of Age
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE childhood; hearing; otitis media; tinnitus
ID CHILDREN; DEPRESSION; DISORDERS; SUFFERERS; EAR
AB Objectives: Tinnitus is associated with hearing loss in adulthood, often resulting from noise or age, but it is not known whether children's hearing and/or middle ear health predispose them to tinnitus in adulthood.
   Methods: The participants were members of the Dunedin Multidisciplinary Health and Development Study, born in Dunedin, New Zealand, between April 1972 and March 1973. The base sample consisted of 1,037 children. Otitis media was assessed at 5, 7, and 9 years of age; audiometry and tympanometry findings were recorded at 11 years of age, and a detailed description of the tympanic membrane was made at 15 years of age. At 32 years of age, 970 of the 1,015 living study members (96%) answered questions about tinnitus.
   Results: Children who had otitis media and a raised audiometric threshold went on to experience more tinnitus in adulthood than did those without middle ear disease or those who had otitis media without a raised threshold. In those who had recovered from otitis media, audiometric threshold elevation at lower and higher frequencies was associated with experiencing tinnitus in adulthood. Neither childhood otitis media alone nor elevated thresholds alone predicted adult tinnitus.
   Conclusions: Childhood otitis media with an associated hearing loss in the low and high frequencies was associated with a greater probability of experiencing tinnitus in adulthood.
C1 [Dawes, Patrick J. D.] Dunedin Publ Hosp, Dept Otorhinolaryngol Head & Neck Surg, Dunedin, New Zealand.
   [Welch, David] Univ Otago, Dunedin Multidisciplinary Hlth & Dev Res Unit, Dunedin, New Zealand.
RP Dawes, PJD (reprint author), Dunedin Publ Hosp, Dept Otorhinolaryngol Head & Neck Surg, 201 Great King St, Dunedin, New Zealand.
FU Health Research Council of New Zealand
FX From the Department of Otorhinolaryngology-Head and Neck Surgery,
   Dunedin Hospital (Dawes), and the Dunedin Multidisciplinary Health and
   Development Research Unit, University of Otago (Welch), Dunedin, New
   Zealand. The Dunedin Multidisciplinary Health and Development Research
   Unit is supported by the Health Research Council of New Zealand.
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NR 23
TC 1
Z9 1
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD OCT
PY 2010
VL 119
IS 10
BP 672
EP 676
PG 5
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 662YI
UT WOS:000282849800005
PM 21049852
ER

PT J
AU Vacchi-Suzzi, M
   Bocciolini, C
   Bertarelli, C
   Dall'Olio, D
AF Vacchi-Suzzi, Martino
   Bocciolini, Corso
   Bertarelli, Claudia
   Dall'Olio, Danilo
TI Ki-67 Proliferation Rate as a Prognostic Marker in Major Salivary Gland
   Carcinomas
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE cell proliferation; prognosis; salivary gland neoplasm
ID CELL-PROLIFERATION; PARAFFIN SECTIONS; MUCOEPIDERMOID CARCINOMA; MIB-1
   ANTIBODY; EXPRESSION; TUMORS
AB Objectives: The study was performed to evaluate the prognostic relevance of cell proliferation associated with Ki-67/Mib-1 immunostaining in malignant tumors of the major salivary glands.
   Methods: Cell proliferation was evaluated by Mib-1 antibody against Ki-67 antigen in 41 patients with cancer of the parotid or submandibular glands, including 14 acinic cell carcinomas, 12 ductal carcinomas, 7 mucoepidermoid carcinomas, 5 carcinomas ex pleomorphic adenoma, 1 adenoid cystic carcinoma, I undifferentiated carcinoma, and I polymorphous low-grade adenocarcinoma.
   Results: Patients with Ki-67 values of more than 15% and those with Ki-67 values of 15% or less differed both in disease-free survival (p < 0.001) and in overall survival (p < 0.001). We evaluated the association between Ki-67 and time to recurrence in correlation to age, sex, ductal histotype, and N stage; the Cox regression model was significant (p = 0.013). In the group of patients with T1 and T2 cancers, those with Ki-67 values of 15% or less had better survival rates than did those with Ki-67 values of more than 15% (p = 0.004). In the group of patients with NO cancers, those with Ki-67 values of 15% or less had a better survival than did those with Ki-67 values of more than 15% (p < 0.001).
   Conclusions: To our knowledge, this is the first study to stratify different risk classes in early T1-T2 or NO malignant tumors of the major salivary glands that identified aggressive lesions with elevated Ki-67 expression at an initial stage.
C1 [Vacchi-Suzzi, Martino; Bocciolini, Corso; Dall'Olio, Danilo] Maggiore Hosp, Dept Otolaryngol Head & Neck Surg, Bologna, Italy.
   [Bertarelli, Claudia] Maggiore Hosp, Dept Pathol, Bologna, Italy.
RP Vacchi-Suzzi, M (reprint author), Osped Maggiore Bologna, Dept Otolaryngol Head & Neck Surg, Lgo B Nigrisoli 2, I-40133 Bologna, Italy.
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NR 15
TC 7
Z9 7
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD OCT
PY 2010
VL 119
IS 10
BP 677
EP 683
PG 7
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 662YI
UT WOS:000282849800006
PM 21049853
ER

PT J
AU Burns, JA
   Lopez-Guerra, G
   Heaton, JT
   Kobler, JB
   Kraas, J
   Zeitels, SM
AF Burns, James A.
   Lopez-Guerra, Gerardo
   Heaton, James T.
   Kobler, James B.
   Kraas, Julie
   Zeitels, Steven M.
TI Cooling the "Oven": A Temperature Study of Air and Glottal Tissue During
   Laser Surgery in an Ex Vivo Calf Larynx Model
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE cooling; laser; microlaryngoscopy; thermal damage; vocal cord; vocal
   fold
ID CARBON-DIOXIDE LASER; CHORIOALLANTOIC MEMBRANE; CLINICAL EXPERIENCE;
   THULIUM LASER; SOFT-TISSUE; YAG LASER; CO2-LASER; PAPILLOMATOSIS;
   TRACHEA; LESIONS
AB Objectives: Endoscopic microlaryngeal laser surgery performed with general anesthesia through a laryngoscope speculum generates heat that accumulates at the distal lumen, creating an "oven" effect and potentially causing bystander thermal damage to nontarget tissue such as the contralateral vocal fold. We report the effects of cooling on air and tissue temperatures that occurred during simulated laryngeal laser surgery with KTP and thulium lasers in an ex vivo calf model.
   Methods: Ten fresh excised calf larynges were studied at room temperature. Laser energy was applied to one vocal fold for 2 minutes, with or without cooling, while temperatures were monitored with sensors placed within the glottal lumen or inserted superficially into the contralateral vocal fold. A pulsed KTP laser (525 mJ) was used for 5 larynges, and a thulium laser (7 W, continuous) was used for the other 5 larynges.
   Results: Heating was slightly greater for the KTP laser than for the thulium laser with use of these parameters. The lumen temperatures for both lasers increased an average of 13.2 degrees C without cooling, but only 6.7 degrees C with cooling (p < 0.05). The contralateral vocal fold (subepithelial space) temperature increased an average of 6.8 degrees C without cooling, but only 4.2 degrees C with cooling (p > 0.05).
   Conclusions: Cooling with room-temperature air during laryngeal laser surgery reduces luminal air and contralateral vocal fold temperatures. This effect is believed to be due to elimination of the plume of steam and smoke that significantly heats surrounding structures.
C1 [Burns, James A.] Massachusetts Gen Hosp, Ctr Laryngeal Surg & Voice Rehabil, Boston, MA 02114 USA.
   Harvard Univ, Sch Med, Dept Surg, Boston, MA 02115 USA.
RP Burns, JA (reprint author), Massachusetts Gen Hosp, Ctr Laryngeal Surg & Voice Rehabil, 1 Bowdoin Sq,11th Floor, Boston, MA 02114 USA.
FU Institute of Laryngology and Voice Restoration; Eugene B. Casey
   Foundation
FX From the Department of Surgery, Harvard Medical School, and the Center
   for Laryngeal Surgery and Voice Rehabilitation, Massachusetts General
   Hospital, Boston, Massachusetts. This work was supported in part by the
   Institute of Laryngology and Voice Restoration and the Eugene B. Casey
   Foundation. Dr Zeitels has an equity interest in Endocraft LLC, which
   makes the glottiscope that was used in the study.
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NR 21
TC 2
Z9 2
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD OCT
PY 2010
VL 119
IS 10
BP 684
EP 689
PG 6
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 662YI
UT WOS:000282849800007
PM 21049854
ER

PT J
AU Suehiro, A
   Hirano, S
   Kishimoto, Y
   Tateya, I
   Rousseau, B
   Ito, J
AF Suehiro, Atsushi
   Hirano, Shigeru
   Kishimoto, Yo
   Tateya, Ichiro
   Rousseau, Bernard
   Ito, Juichi
TI Effects of Basic Fibroblast Growth Factor on Rat Vocal Fold Fibroblasts
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE basic fibroblast growth factor; extracellular matrix; gene expression;
   rat model; vocal fold scar
ID CANINE MODEL; RABBIT MODEL; HYALURONAN; REGENERATION; SCAR; EXPRESSION;
   CYTOKINES; COLLAGEN; ULCERS; WOUNDS
AB Objectives: The overarching goal of this line of research is to translate basic fibroblast growth factor (bFGF) treatment for vocal fold scarring into practical clinical use. In a previous canine investigation, we demonstrated that bFGF improves phonation threshold pressure, mucosal wave amplitude, and histologic measures in vocal folds treated after injury. In the present study, we studied the effects of bFGF on gene expression of the extracellular matrix and growth factors in rat vocal fold fibroblasts.
   Methods: Fibroblasts harvested from the vocal folds of 5 rats were treated with 3 concentrations of bFGF (0, 10, and 100 ng/mL). The fibroblasts were collected at 24 hours and 72 hours after bFGF administration. Quantitative polymerase chain reaction was then used to investigate the gene expression of the investigated growth factors and extracellular matrices.
   Results: The results revealed significantly down-regulated expression of procollagen I and significantly up-regulated expression of hyaluronic acid synthase (HAS) 2 and fibronectin in fibroblasts treated with bFGF. The administration of bFGF also resulted in the up-regulation of bFGF and hepatocyte growth factor (HGF). No changes in the expression of HAS-1, tropoelastin, or procollagen III were observed between the treatment and control conditions.
   Conclusions: Treatment with bFGF induces the down-regulation of procollagen I and the up-regulation of HAS-2 in vocal fold fibroblast cell cultures. These gene expression alterations to key mediators of the wound healing process may translate into potential benefits in the remediation of vocal fold injury. The up-regulation of HGF, an antifibrotic effector molecule, may demonstrate additional benefits by optimizing the wound healing environment and by accelerating the wound repair cascade. These findings may provide fuel for additional discoveries into the development of growth factor therapy for the treatment of vocal fold scar.
C1 [Suehiro, Atsushi; Hirano, Shigeru; Kishimoto, Yo; Tateya, Ichiro; Ito, Juichi] Kyoto Univ, Grad Sch Med, Dept Otolaryngol Head & Neck Surg, Sakyo Ku, Kyoto 6068507, Japan.
   [Suehiro, Atsushi; Rousseau, Bernard] Vanderbilt Univ, Bill Wilkerson Ctr Otolaryngol & Commun Sci, Dept Otolaryngol, Nashville, TN USA.
RP Hirano, S (reprint author), Kyoto Univ, Grad Sch Med, Dept Otolaryngol Head & Neck Surg, Sakyo Ku, 54 Kawaharacho, Kyoto 6068507, Japan.
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NR 39
TC 8
Z9 8
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD OCT
PY 2010
VL 119
IS 10
BP 690
EP 696
PG 7
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 662YI
UT WOS:000282849800008
PM 21049855
ER

PT J
AU Imaizumi, M
   Nomoto, Y
   Sugino, T
   Miyake, M
   Wada, I
   Nakamura, T
   Omori, K
AF Imaizumi, Mitsuyoshi
   Nomoto, Yukio
   Sugino, Takashi
   Miyake, Masao
   Wada, Ikuo
   Nakamura, Tatsuo
   Omori, Koichi
TI Potential of Induced Pluripotent Stem Cells for the Regeneration of the
   Tracheal Wall
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE bioengineered scaffold; chondrogenesis; induced pluripotent stem cell;
   regeneration; tracheal wall
ID CHONDROGENIC DIFFERENTIATION; DIRECTED DIFFERENTIATION; SUBGLOTTIC
   STENOSIS; CARTILAGE; RECONSTRUCTION; GENERATION; REPAIR; VITRO
AB Objectives: Our previous studies focused on basic research and the clinical applications of an artificial trachea. However, the prefabricated artificial trachea cannot be utilized for pediatric airways, because the tracheal frame needs to expand as the child develops. The purpose of this study was to evaluate the potential of induced pluripotent stem (iPS) cells for the regeneration of the tracheal wall.
   Methods: We cultured iPS cells in a 3-dimensional (3-D) scaffold in chondrocyte differentiation medium (bioengineered scaffold model), and the results were compared with those in a 3-D scaffold without iPS cells (control scaffold model). The 3-D scaffolds were implanted into tracheal defects in 8 nude rats. After 4 weeks, the regenerated tissue was histologically examined.
   Results: Implanted iPS cells were confirmed to exist in all 5 rats implanted with bioengineered scaffolds. Cartilage-like tissue was observed in the regenerated tracheal wall in 2 of the 5 rats in the bioengineered scaffold model, but in none of the 3 rats in the control scaffold model.
   Conclusions: Implanted iPS cells were confirmed to exist in the bioengineered scaffold. Cartilage-like tissue was regenerated in the tracheal defect. This study demonstrated the potential of iPS cells in the regeneration of the tracheal wall.
C1 [Imaizumi, Mitsuyoshi; Nomoto, Yukio; Omori, Koichi] Fukushima Med Univ, Sch Med, Dept Otolaryngol, Fukushima 9601295, Japan.
   [Sugino, Takashi] Fukushima Med Univ, Sch Med, Dept Basic Pathol, Fukushima 9601295, Japan.
   [Miyake, Masao] Fukushima Med Univ, Sch Med, Dept Physiol 1, Fukushima 9601295, Japan.
   [Wada, Ikuo] Fukushima Med Univ, Sch Med, Inst Biomed Sci, Dept Cell Sci, Fukushima 9601295, Japan.
   [Nakamura, Tatsuo] Kyoto Univ, Inst Frontier Med Sci, Dept Bioartificial Organs, Kyoto, Japan.
RP Imaizumi, M (reprint author), Fukushima Med Univ, Sch Med, Dept Otolaryngol, 1 Hikarigaoka, Fukushima 9601295, Japan.
FU Japan Society for the Promotion of Science
FX From the Department of Otolaryngology (Imaizumi, Nomoto, Omori), the
   Department of Basic Pathology (Sugino), the First Department of
   Physiology (Miyake), and the Department of Cell Science, Institute of
   Biomedical Sciences (Wada), School of Medicine, Fukushima Medical
   University, Fukushima City, and the Department of Bioartificial Organs,
   Institute for Frontier Medical Sciences, Kyoto University, Kyoto
   (Nakamura), Japan. This study was supported in part by a Challenging
   Exploratory Research grant from the Japan Society for the Promotion of
   Science and in part by a Grant-in-Aid for Young Scientists (Startup)
   from the Japan Society for the Promotion of Science.
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   Taura D, 2009, ARTERIOSCL THROM VAS, V29, P1100, DOI 10.1161/ATVBAHA.108.182162
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NR 26
TC 13
Z9 13
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD OCT
PY 2010
VL 119
IS 10
BP 697
EP 703
PG 7
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 662YI
UT WOS:000282849800009
PM 21049856
ER

PT J
AU Goudy, S
   Bauman, N
   Manaligod, J
   Smith, RJH
AF Goudy, Steven
   Bauman, Nancy
   Manaligod, Jose
   Smith, Richard J. H.
TI Congenital Laryngeal Webs: Surgical Course and Outcomes
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE 22q11 deletion; airway reconstruction; laryngeal web
ID ANTERIOR GLOTTIC WEB; MANAGEMENT; ATRESIAS
AB Objectives: We compare the success of different surgical options in the treatment of laryngeal webs.
   Methods: We performed a retrospective study spanning the years 1980 to 2005.
   Results: Eighteen patients were identified. The average age at diagnosis was 6 months (range, 1 day to 2.5 years). The presenting symptoms included weak cry, stridor, airway obstruction, and difficulty breathing. Associated cardiac defects consistent with the diagnosis of 22q-syndrome were present in 7 patients. Webs were classified as grade I (5 patients), grade II (2 patients), grade III (10 patients), or grade IV (1 patient) according to the Cohen classification. In 5 patients, only endoscopic lysis was required. The remaining 13 patients underwent open procedures; 9 patients in this group required tracheotomy. An average of 1.3 open airway procedures was necessary to achieve a decannulation rate of 89%. After operation, 34% of patients had residual webbing and 20% had a weak or aphonic voice.
   Conclusions: Management of laryngeal webs is dependent on the severity of airway obstruction. Grade I and II webs can be treated endoscopically; more severe laryngeal webs usually require tracheotomy and open airway reconstruction.
C1 [Goudy, Steven] Vanderbilt Univ, Dept Otolaryngol, Nashville, TN USA.
   [Bauman, Nancy] Georgetown Univ, Childrens Med Ctr, Div Pediat Otolaryngol, Washington, DC 20007 USA.
   [Manaligod, Jose; Smith, Richard J. H.] Univ Iowa, Dept Otolaryngol, Iowa City, IA USA.
RP Goudy, S (reprint author), 2200 Childrens Way,Doctors Off Tower,7th Floor, Nashville, TN 37232 USA.
CR BENJAMIN B, 1983, ANN OTO RHINOL LARYN, V92, P317
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   Miyamoto RC, 2004, OTOLARYNG HEAD NECK, V130, P415, DOI 10.1016/j.otohns.2003.12.014
   Nicollas R, 2008, OTOLARYNG CLIN N AM, V41, P877, DOI 10.1016/j.otc.2008.04.008
   Tunkel DE, 2005, INT J PEDIATR OTORHI, V69, P893, DOI 10.1016/j.ijporl.2005.02.005
   Unal M, 2004, INT J PEDIATR OTORHI, V68, P231, DOI 10.1016/j.ijporl.2003.09.018
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   ZAWTUN HIA, 1988, ANN OTO RHINOL LARYN, V97, P353
NR 15
TC 0
Z9 0
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD OCT
PY 2010
VL 119
IS 10
BP 704
EP 706
PG 3
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 662YI
UT WOS:000282849800010
PM 21049857
ER

PT J
AU Hachiya, A
   Imamura, R
   Parra, ER
   Sennes, LU
   Tsuji, DH
AF Hachiya, Adriana
   Imamura, Rui
   Parra, Edwin Roger
   Sennes, Luiz Ubirajara
   Tsuji, Domingos Hiroshi
TI Histologic Study of Perifascial Areolar Tissue Implanted in Rabbit Vocal
   Folds: An Experimental Study
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE animal model; collagen; graft; histology; scar; vocal fold
ID INJECTABLE COLLAGEN; AUTOLOGOUS TRANSPLANTATION; FAT IMPLANTATION;
   PICROSIRIUS RED; SULCUS VOCALIS; INJECTION; FASCIA; MANAGEMENT; CANINE
AB Objectives: Perifascial areolar tissue (PAT) consists of loose areolar tissue with viscoelastic properties that are similar to those found in tissues in the superficial layer of the vocal fold. The aim of this study was to quantify the inflammatory process and the collagen content of the graft, as well as that of the host tissue, after placement of a strip of PAT into the rabbit vocal fold.
   Methods: Surgeries were performed on 30 rabbits. The grafts were implanted in pockets that were surgically created in the right vocal fold. The left vocal fold (control group) was subjected only to surgical manipulation. The animals were divided into 3 groups for evaluations at 15 days, 3 months, and 6 months, and their larynx tissues were subsequently reviewed by histology.
   Results: The grafts were characterized by disorganized and thick collagen bundles and were identified in all study groups. The collagen density stayed constant over time. There was an acute inflammatory response induced by the graft at 15 clays that did not exist in the specimens taken at 3 and 6 months. Deposition of collagen fibers in the lamina propria was observed starting at 15 days after the operation and was more intense in the experimental vocal fold than in the control vocal fold.
   Conclusions: Our findings indicated that PAT has a low tendency for promoting an inflammatory response. However, there was a loss of the original architecture of the graft tissue and a greater deposition of collagen in the implanted vocal folds than in the control group.
C1 [Hachiya, Adriana; Imamura, Rui; Sennes, Luiz Ubirajara; Tsuji, Domingos Hiroshi] Univ Sao Paulo, Sch Med, Dept Otolaryngol, Sao Paulo, Brazil.
   [Parra, Edwin Roger] Univ Sao Paulo, Sch Med, Dept Pathol, Sao Paulo, Brazil.
RP Hachiya, A (reprint author), Rua Doutor Barachisio Lisboa 88, BR-05441090 Sao Paulo, Brazil.
EM adrihachiya@uol.com.br
RI Sennes, Luiz/E-6815-2012
FU Brazilian National Research Council
FX From the Departments of Otolaryngology (Hachiya, Imamura, Scillies,
   Tsuji) and Pathology (Parra), The University of Silo Paulo School of
   Medicine, Sao Paulo, Brazil. This work was supported by the Brazilian
   National Research Council. The animal use protocol met the guidelines of
   the Brazilian Association for Laboratory Animal Science (Colegio
   Brasileiro de Experimentacao Animal; COBEA) and received Institutional
   Review Board approval (research protocol 1017/05).
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NR 31
TC 0
Z9 0
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD OCT
PY 2010
VL 119
IS 10
BP 707
EP 715
PG 9
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 662YI
UT WOS:000282849800011
PM 21049858
ER

PT J
AU Feinberg, S
   Lopez-Guerra, G
   Zeitels, SM
AF Feinberg, Steven
   Lopez-Guerra, Gerardo
   Zeitels, Steven M.
TI Hypopharyngeal Extrusion of 2.5 Feet (76 cm) of Polytetrafluoroethylene
   (Gore-Tex): Initial Laser-Assisted Office-Based Removal and
   Micropharyngeal Completion
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT 89th Annual Meeting of the American-Broncho-Esophagological-Association
CY MAY 28-29, 2009
CL Phoenix, AZ
SP Amer Broncho Esophagol Assoc
DE Gore-Tex; KTP laser; laryngoplasty; larynx; laser;
   polytetrafluoroethylene; vocal cord; vocal cord paralysis; vocal fold
ID MEDIALIZATION LARYNGOPLASTY; FIBER
AB Extrusion of an implant after medialization laryngoplasty is unusual and warrants removal. Most commonly, it extrudes through the laryngeal introitus, but rarely, it extrudes through the pyriform sinus. A case report in which 2.5 feet (76 cm) of polytetrafluoroethylene (Gore-Tex) was removed from an 80-year-old female patient is presented to evaluate factors that led to this surgical complication and strategies that solved the problem. Because of the patient's multiple medical problems, initial removal of the foreign body was attempted in the office with topical anesthesia. When the Gore-Tex was noted to be lodged in the laryngeal parenchyma, it was severed at the edge of the pyriform sinus to stabilize the airway. Subsequently, microlaryngoscopic-controlled completion removal was done in the operating room with general anesthesia. The patient healed uneventfully with no further sequelae. Analysis of this case illustrates a number of factors leading to a rare iatrogenic foreign body complication. Office-based removal of the Gore-Tex implant evolved into a unique scenario in which the rapid use of a fiber-based laser to divide the foreign body facilitated stabilizing the airway to allow for elective completion removal in a controlled fashion.
C1 [Feinberg, Steven; Lopez-Guerra, Gerardo; Zeitels, Steven M.] Massachusetts Gen Hosp, Ctr Laryngeal Surg & Voice Rehabil, Boston, MA 02114 USA.
   [Lopez-Guerra, Gerardo; Zeitels, Steven M.] Harvard Univ, Sch Med, Dept Surg, Boston, MA 02115 USA.
RP Zeitels, SM (reprint author), Massachusetts Gen Hosp, Ctr Laryngeal Surg & Voice Rehabil, 1 Bowdoin Sq,11th Floor, Boston, MA 02114 USA.
CR McCulloch TM, 1998, ANN OTO RHINOL LARYN, V107, P427
   McCulloch TM, 2000, LARYNGOSCOPE, V110, P1306, DOI 10.1097/00005537-200008000-00015
   Tucker GF, 1971, HUMAN LARYNX CORONAL
   Zeitels SM, 2003, NEW ENGL J MED, V349, P882, DOI 10.1056/NEJMra035148
   Zeitels SM, 2006, ANN OTO RHINOL LARYN, V115, P535
   Zeitels SM, 2003, ANN OTO RHINOL LARYN, V112, P180
   Zeitels SM, 2006, ANN OTO RHINOL LARYN, V115, P891
   Zeitels SM, 2000, OTOLARYNG CLIN N AM, V33, P841, DOI 10.1016/S0030-6665(05)70247-4
   Zeitels SM, 2006, ANN OTO RHINOL LARYN, V115, P679
NR 9
TC 2
Z9 2
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD SEP
PY 2010
VL 119
IS 9
BP 573
EP 577
PG 5
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 648TA
UT WOS:000281715800001
PM 21033022
ER

PT J
AU Ramadan, HH
   Terrell, AM
AF Ramadan, Hassan H.
   Terrell, Andrew M.
TI Balloon Catheter Sinuplasty and Adenoidectomy in Children With Chronic
   Rhinosinusitis
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT 113th Annual Meeting of the
   American-Academy-of-Otolaryngology-Head-and-Neck-Surgery-Foundation
CY OCT 04-07, 2009
CL San Diego, CA
SP Amer Acad Otolaryngol Head & Neck Surg Fdn
DE balloon; pediatrics; sinuplasty; sinusitis
ID ENDOSCOPIC SINUS SURGERY; SINONASAL SYMPTOMS; OUTCOMES; GROWTH
AB Objectives: Adenoidectomy is the first step in the surgical management of children with chronic rhinosinusitis (CRS). Adenoidectomy, however, is only effective in half of these children. Although endoscopic sinus surgery is effective for CRS, there is concern for facial growth retardation and major complications. We propose that balloon catheter sinuplasty (BCS) is a minimally invasive, effective procedure in the treatment of pediatric CRS.
   Methods: We undertook a nonrandomized, controlled, prospective review of children with failed medical management of CRS who underwent BCS or adenoidectomy. Outcomes were assessed at 1 year of follow-up and were based on SN-5 scores and the need for revision surgery.
   Results: Forty-nine children who satisfied the inclusion criteria were reviewed. Thirty of the children had BCS. The age range was 4 to 11 years (mean, 7.7 years), and the mean computed tomography score (Lund-Mackay system) was 7.5. Twenty-four of the 30 patients (80%) who underwent BCS showed improvement of their symptoms after 12 months of follow-up, compared with 10 of the 19 patients (52.6%) who underwent adenoidectomy (p < 0.05). A multivariate analysis using logistic regression analysis with age, sex, asthma, and computed tomography score as covariables showed that BCS was also more effective than adenoidectomy in older children. None of the other variables showed statistical significance.
   Conclusions: Balloon catheter sinuplasty offers a procedure that is more effective than adenoidectomy and less invasive than endoscopic sinus surgery in the treatment of pediatric CRS.
C1 [Ramadan, Hassan H.; Terrell, Andrew M.] W Virginia Univ, Dept Otolaryngol, Sch Med, Morgantown, WV 26506 USA.
   [Ramadan, Hassan H.] Acclarent Inc, Menlo Pk, CA USA.
RP Ramadan, HH (reprint author), W Virginia Univ, Dept Otolaryngol Head & Neck Surg, POB 9200, Morgantown, WV 26506 USA.
CR Benninger MS, 2003, OTOLARYNG HEAD NECK, V129, pS1, DOI 10.1016/S0194-5998(03)01397-4
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   Carpenter KM, 1997, AM J RHINOL, V11, P211, DOI 10.2500/105065897781751929
   Chang PH, 2004, ARCH OTOLARYNGOL, V130, P1033, DOI 10.1001/archotol.130.9.1033
   Hebert RL, 1998, LARYNGOSCOPE, V108, P796, DOI 10.1097/00005537-199806000-00004
   Kay DJ, 2003, OTOLARYNG HEAD NECK, V128, P17, DOI 10.1067/mhn.2003.41
   Keerl R, 1999, LARYNGOSCOPE, V109, P546, DOI 10.1097/00005537-199904000-00005
   Lee D, 1997, OTOLARYNG HEAD NECK, V116, P301, DOI 10.1016/S0194-5998(97)70264-X
   Levine HL, 2008, ANN OTO RHINOL LARYN, V117, P263
   Lund VJ, 1997, OTOLARYNGOL HEAD NEC, V117, P35
   LUSK RP, 1990, LARYNGOSCOPE, V100, P654
   Melroy CT, 2008, OTOLARYNG HEAD NECK, V139, pS23, DOI 10.1016/j.otohns.2008.05.017
   PAUL D, 1981, LARYNGOSCOPE, V91, P997
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   Ramadan HH, 2004, LARYNGOSCOPE, V114, P2103, DOI 10.1097/01.mlg.0000149441.28232.0c
   Ramadan HH, 2009, ANN OTO RHINOL LARYN, V118, P161
   Ramadan HH, 2010, AM J RHINOL ALLERGY, V24, pE54, DOI 10.2500/ajra.2010.24.3431
   Ray NF, 1999, J ALLERGY CLIN IMMUN, V103, P408, DOI 10.1016/S0091-6749(99)70464-1
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NR 20
TC 16
Z9 16
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD SEP
PY 2010
VL 119
IS 9
BP 578
EP 582
PG 5
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 648TA
UT WOS:000281715800002
PM 21033023
ER

PT J
AU Levo, H
   Stephens, D
   Poe, D
   Kentala, E
   Pyykko, I
AF Levo, Hella
   Stephens, Dafydd
   Poe, Dennis
   Kentala, Erna
   Pyykko, Ilmari
TI Use of ICF in Assessing the Effects of Meniere's Disorder on Life
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE disease-specific impact; EuroQol; ICF; Meniere's disorder; quality of
   life
ID QUALITY-OF-LIFE; DISEASE; SCALE; DISABILITY; VERTIGO; CARE
AB Objectives: We sought to determine the value of the World Health Organization's International Classification of Functioning. Disability and Health (ICF) in subjects with Meniere's disorder in relation to their quality of life.
   Methods: We asked 228 members of the Finnish Meniere Federation to report the effects that Meniere's disorder had on their lives. The replies were classified on the basis of the ICF classification and related to the EuroQol 5D score and disease-specific impact. Logistic regression and decision tree analyses were used to determine the relationships.
   Results: Seventy percent of the patients listed impairments, 39% activity limitations, 47% participation restrictions. 16% effects On environmental contextual factors, and 28% effects on personal contextual factors. The EuroQol 5D score was explained by reported vertigo, anxiety, fatigue, restriction of life, and communication problems. The disease-specific impact was explained by episodes of vertigo, fatigue, communication problems, inability to work, restriction of life, and uncertainty of life. Both analysis models provided the same outcome variables, although the decision tree separated the results better (80%) into correct classes than did logistic regression analysis (60%).
   Conclusions: Self-reported participation restriction, activity limitation, and personal contextual factors describe the limitations of general life in subjects with Meniere's disorder. The use of the ICF classification provides an instrument that can be used in enablement of subjects with Meniere's disorder.
C1 [Levo, Hella; Kentala, Erna] Univ Helsinki, Cent Hosp, Dept Otorhinolaryngol, Helsinki, Finland.
   [Poe, Dennis; Pyykko, Ilmari] Univ Tampere, Sch Med, Dept Otorhinolaryngol, FIN-33101 Tampere, Finland.
   [Stephens, Dafydd] Cardiff Univ, Sch Med, Dept Neurol Ophthalmol & Audiol Med, Cardiff, S Glam, Wales.
RP Levo, H (reprint author), Univ Helsinki, Cent Hosp, Dept Otolaryngol, POB 220,Haartmaninkatu 4E, Helsinki 00029, Finland.
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NR 27
TC 9
Z9 9
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD SEP
PY 2010
VL 119
IS 9
BP 583
EP 589
PG 7
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 648TA
UT WOS:000281715800003
PM 21033024
ER

PT J
AU Liakos, T
   Kaye, K
   Rubin, AD
AF Liakos, Tracey
   Kaye, Keith
   Rubin, Adam D.
TI Methicillin-Resistant Staphylococcus aureus Laryngitis
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE bacterial laryngitis; dysphonia; laryngitis; methicillin-resistant
   Staphylococcus aureus
ID INFECTIONS; COMMUNITY; RHINOSINUSITIS; SURGERY; SKIN
AB Infections due to methicillin-resistant Staphylococcus aureus (MRSA) have become more prevalent, in part because of the emergence and spread of community-acquired MRSA. This trend is particularly concerning because of the significant rates of morbidity and mortality associated with MRSA infections, and because MRSA strains are often resistant to many classes of antibiotics. Reports of infections of the head and neck, including wound infections, cellulitis, sinusitis, otitis media, and otitis externa, are well documented. However, to our knowledge, there have been no reports of bacterial laryngitis due to MRSA. We report the first published case of bacterial laryngitis caused by MRSA.
C1 [Rubin, Adam D.] Lakeshore Ear Nose & Throat Ctr, PC, St Clair Shores, MI 48081 USA.
   [Liakos, Tracey] St John Macomb Oakland Hosp, Dept Otolaryngol, Madison Hts, MI USA.
   [Kaye, Keith] Wayne State Univ, Dept Med, Detroit Med Ctr, Detroit, MI 48202 USA.
RP Rubin, AD (reprint author), Lakeshore Ear Nose & Throat Ctr, PC, 21000 12 Mile Rd,Suite 111, St Clair Shores, MI 48081 USA.
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   KAYE SK, EMERG INFECT DIS
   King MD, 2006, ANN INTERN MED, V144, P309
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NR 22
TC 2
Z9 2
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD SEP
PY 2010
VL 119
IS 9
BP 590
EP 593
PG 4
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 648TA
UT WOS:000281715800004
PM 21033025
ER

PT J
AU Stepp, CE
   Heaton, JT
   Jette, ME
   Burns, JA
   Hillman, RE
AF Stepp, Cara E.
   Heaton, James T.
   Jette, Marie E.
   Burns, James A.
   Hillman, Robert E.
TI Neck Surface Electromyography as a Measure of Vocal Hyperfunction Before
   and After Injection Laryngoplasty
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE electromyography; injection laryngoplasty; speech acoustics; vocal
   hyperfunction
ID MUSCLE TENSION DYSPHONIA; PARKINSON-DISEASE; THYROID-SURGERY; VOICE
   DISORDERS; COMPRESSION; PROTOCOL; OUTCOMES; ONSET; EMG
AB Objectives: The goal of this preliminary study was to determine whether neck surface electromyography (sEMG) is sensitive to possible changes in vocal hyperfunction associated with injection laryngoplasty, particularly with respect to alterations in the degree of vocal hyperfunction.
   Methods: Thirteen individuals undergoing office-based injection laryngoplasty for glottal phonatory insufficiency were prospectively studied with a battery of acoustic, aerodynamic, endoscopic, and anterior neck sEMG assessments before the procedure and approximately 1 week afterward.
   Results: Anterior neck sEMG values were not significantly reduced (p < 0.05) after the procedure; however, perceptual ratings of strain and false vocal fold compression were both significantly reduced, reflecting a decrease in vocal hyperfunction.
   Conclusions: The results do not support the use of anterior neck sEMG measures to assess vocal hyperfunction, and place into question the use of some other measures (estimates of anterior-posterior supraglottic compression, quantitative measures of anterior-posterior and false vocal fold supraglottic compression, and acoustic vowel rise times) that have been considered reflective of vocal hyperfunction.
C1 [Stepp, Cara E.; Heaton, James T.; Jette, Marie E.; Burns, James A.; Hillman, Robert E.] Massachusetts Gen Hosp, Ctr Laryngeal Surg & Voice Rehabil, Boston, MA 02114 USA.
   [Heaton, James T.; Burns, James A.; Hillman, Robert E.] Harvard Univ, Sch Med, Dept Surg, Boston, MA 02115 USA.
   [Stepp, Cara E.; Hillman, Robert E.] Harvard Massachusetts Inst Technol, Div Hlth Sci & Technol, Cambridge, MA USA.
RP Stepp, CE (reprint author), Univ Washington, Comp Sci & Engn Box 352350, Seattle, WA 98195 USA.
FU National Institute on Deafness and Other Communication Disorders
   [5T32DC000038-17]
FX From the Center for Laryngeal Surgery and Voice Rehabilitation,
   Massachusetts General Hospital (all authors), and the Department of
   Surgery, Harvard Medical School (Heaton, Burns, Hillman), Boston, and
   the Division of Health Science and Technology, Harvard-Massachusetts
   Institute of Technology, Cambridge (Stepp, Hillman), Massachusetts. This
   work was supported in part by grant 5T32DC000038-17 from the National
   Institute on Deafness and Other Communication Disorders.
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NR 26
TC 4
Z9 5
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD SEP
PY 2010
VL 119
IS 9
BP 594
EP 601
PG 8
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 648TA
UT WOS:000281715800005
PM 21033026
ER

PT J
AU Sakae, FA
   Imamura, R
   Sennes, LU
   Tsuji, DH
   Mauad, T
   Saldiva, PHN
AF Sakae, Flavio Akira
   Imamura, Rui
   Sennes, Luiz Ubirajara
   Tsuji, Domingos Hiroshi
   Mauad, Thais
   Nascimento Saldiva, Paulo Hilario
TI Elastic Fibers in Reinke's Edema
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE elastic fiber; lamina propria; Reinke's edema; vocal fold
ID VOCAL FOLDS; LAMINA PROPRIA; HYALURONIC-ACID; BENIGN LESIONS; COLLAGEN;
   LAYER
AB Objectives: We describe the distribution of elastic system fibers in the superficial layer of the lamina propria of Reinke's edema, as compared with normal vocal folds.
   Methods: Weigert's resorcin-fuchsin stain after oxidation with 10% oxone was used to study the arrangement of elastic fibers. The findings were categorized and afterward compared with the severity of Reinke's edema.
   Results: Analysis of 20 specimens of vocal folds with Reinke's edema showed that the network of thin elastic fibers in Reinke's space lost their undulated appearance and had a tangled aspect. In addition, these fibers were no longer parallel to the epithelial basement membrane, but had a random distribution scattered throughout Reinke's space. The elastic fiber network immediately below the epithelial basement membrane also appeared more fragmented in Reinke's edema because of some alteration in organization combined with the 5-mu m-thick histologic sectioning plane. No significant difference in the degree of elastic system fiber disarrangement was observed between severity grades II and III (p = 0.382). Large areas of disarrangement were predominant (80% of cases).
   Conclusions: The disarrangement of elastic fibers in Reinke's edema may cause insufficient tissue resistance and resilience, contributing to the hypermobility observed in Reinke's edema.
C1 [Sakae, Flavio Akira; Imamura, Rui; Sennes, Luiz Ubirajara; Tsuji, Domingos Hiroshi] Univ Sao Paulo, Sch Med, Dept Otorhinolaryngol, Sao Paulo, Brazil.
   [Mauad, Thais; Nascimento Saldiva, Paulo Hilario] Univ Sao Paulo, Sch Med, Dept Pathol, Sao Paulo, Brazil.
RP Sakae, FA (reprint author), Rua Nanuque 432,Apto 102,05302-031, Sao Paulo, Brazil.
RI Saldiva, Paulo/D-7385-2012; Sennes, Luiz/E-6815-2012; Mauad,
   Thais/G-1254-2012
FU CNPQ (Brazilian National Research Council); HC-FMUSP (University of Sao
   Paulo School of Medicine)
FX From the Departments of Otorhinolaryngology (Sakae, Imamura, Sennes,
   Tsuji) and Pathology (Mauad. Saldiva), University of Sao Paulo School of
   Medicine, Sao Paulo, Brazil. This work was supported by CNPQ (Brazilian
   National Research Council) and HC-FMUSP (University of Sao Paulo School
   of Medicine).
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NR 19
TC 1
Z9 1
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD SEP
PY 2010
VL 119
IS 9
BP 609
EP 614
PG 6
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 648TA
UT WOS:000281715800007
PM 21033028
ER

PT J
AU Suzuki, M
   Hashimoto, S
   Kano, S
   Okitsu, T
AF Suzuki, Masaaki
   Hashimoto, Sho
   Kano, Shigeyuki
   Okitsu, Takuji
TI Prevalence of Acoustic Neuroma Associated With Each Configuration of
   Pure Tone Audiogram in Patients With Asymmetric Sensorineural Hearing
   Loss
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE acoustic neuroma; idiopathic sudden hearing loss; pure tone audioigram;
   sensorineural hearing loss
ID VESTIBULAR SCHWANNOMAS
AB Objectives: The criteria have not yet been established for identifying the configuration of a pure tone audiogram constituting, abnormal results that warrant further investigation. The purpose of this study was to determine the prevalence of acoustic neuroma associated with each configuration Of the pure tone audiogram in patients with asymmetric sensorineural hearing loss (SNHL).
   Methods: We performed a retrospective chart review of 500 patients 15 years of age or older who had asymmetric SNHL and had undergone magnetic resonance imaging.
   Results: The prevalence of acoustic neuroma in these patients was 2.6% (13 of 500). The prevalence of acoustic neuroma in each audiometric configuration was as follows: 7.1% (3 of 42) for a basin-shaped loss (odds ratio [OR] versus overall prevalence, 2.88; p = 0.23; 95% confidence interval [CI], 0.79 to 10.54), 4.7% (5 of 107) for a flat loss, 3.4% (2 of 58) for total deafness, 2.9% (1 of 34) for a high-frequency sloping audiogram, and 2.5% (2 of 81) for a high-frequency steep audiogram. The prevalence in patients with nonimproving idiopathic sudden deafness was 8.1% (OR, 3.29; p = 0.06; 95% CI. 1.13 to 9.55).
   Conclusions: In conclusion, 2.9% to 8.1% of patients with a characteristic configuration of the pure tone audiogram and symptoms of nonimproving or progressive idiopathic sudden deafness may have acoustic neuroma.
C1 [Suzuki, Masaaki] Teikyo Univ, Sch Med, Dept Otolaryngol, Itabashi Ku, Tokyo 1738605, Japan.
   [Hashimoto, Sho] Natl Sendai Med Ctr, Dept Otolaryngol, Sendai, Miyagi, Japan.
   [Kano, Shigeyuki] Tohoku Univ, Grad Sch Med, Dept Otolaryngol Head & Neck Surg, Sendai, Miyagi 980, Japan.
   [Okitsu, Takuji] Tohoku Bunka Gakuen Univ, Dept Speech Pathol & Audiol, Sendai, Miyagi, Japan.
RP Suzuki, M (reprint author), Teikyo Univ, Sch Med, Dept Otolaryngol, Itabashi Ku, 2-11-1 Kaga, Tokyo 1738605, Japan.
CR Day AS, 2008, ACTA OTO-LARYNGOL, V128, P756, DOI 10.1080/00016480701749240
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   Fortnum H, 2009, HEALTH TECHNOL ASSES, V13, P1
   Fortnum H, 2009, HEALTH TECHNOL ASSES, V13, pix
   Forton GEJ, 2004, ANN OTO RHINOL LARYN, V113, P582
   Inoue Y, 2000, J LARYNGOL OTOL, V114, P589
   MOFFAT DA, 1993, J LARYNGOL OTOL, V107, P290, DOI 10.1017/S0022215100122856
   MOFFAT DA, 1989, J LARYNGOL OTOL, V103, P835, DOI 10.1017/S0022215100110242
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   Nageris BI, 2003, ANN OTO RHINOL LARYN, V112, P395
   National Institute for Health, 1991, NIH CONSENSUS STATE, V9, P1
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NR 16
TC 5
Z9 5
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD SEP
PY 2010
VL 119
IS 9
BP 615
EP 618
PG 4
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 648TA
UT WOS:000281715800008
PM 21033029
ER

PT J
AU Bent, JP
   Shah, MB
   Nord, R
   Parikh, SR
AF Bent, John P.
   Shah, Maulik B.
   Nord, Ryan
   Parikh, Sanjay R.
TI Balloon Dilation for Recurrent Stenosis After Pediatric
   Laryngotracheoplasty
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE airway. balloon; dilation; laryngoplasty; pediatrics; subglottis
ID SUBGLOTTIC STENOSIS; CHILDREN; RECONSTRUCTION; TRACHEOPLASTY;
   DILATATION; EXPERIENCE; TRACHEAL
AB Objectives: We assessed the safety and efficacy of balloon dilation as treatment for recurrent stenosis after pediatric laryngotracheoplasty.
   Methods: We studied a retrospective case series at an academic tertiary care children's hospital. We included all patients under the age of 18 years with subglottic or tracheal stenosis treated at our institution with balloon dilation between June 2007 and April 2009. The records were analyzed for patient demographics, presenting symptoms, surgical technique, and airway description. The outcome measures were airway diameter, postoperative symptoms, tracheotomy status. and complications.
   Results: Ten patients (9 with subglottic stenosis and I with tracheal stenosis) underwent 20 balloon dilation procedures without complication. The average age at the time of the procedure was 17 months (range, 3 months to 9 years). The patient presenting symptoms were stridor in 7 cases and tracheotomy in 3 cases. Vascular balloons (diameter range. 6 to 12 mm; length. 20 mm) were inflated to 10 to 12 cm H(2)O pressure for an average of 40 seconds (range, 10 to 120 seconds). Each procedure consisted of 1 to 3 dilation cycles. The immediate postdilation airway area increased by an average factor of 4.9 (range, 1.9 to 9). Six patients had repeat procedures with an average interval between dilations of 67 days (range, 6 to 337 clays). Stridor was eliminated or greatly improved in all patients on the first postoperative day; 7 patients sustained this benefit, with an average follow-up time of 10 months (range. 4 to 23 months). Six of the 10 patients had undergone previous laryngeal reconstruction (age range, 3 months to 4 years). Of these 6. 3 have no tracheotomy, with a mean follow-up of 12.5 months. The 3 children who benefited the least from dilation were noted to have more diffuse and chronic inflammation of the larynx in comparison to the responders.
   Conclusions: This case series suggests that balloon dilation is a relatively safe and effective procedure. It may be particularly well suited to recent stenosis after laryngotracheal reconstruction.
C1 [Bent, John P.; Shah, Maulik B.; Nord, Ryan; Parikh, Sanjay R.] Childrens Hosp Montefiore, Albert Einstein Coll Med, Dept Otorhinolaryngol, Bronx, NY USA.
RP Bent, JP (reprint author), 3400 Bainbridge Ave, Bronx, NY 10467 USA.
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NR 14
TC 21
Z9 21
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD SEP
PY 2010
VL 119
IS 9
BP 619
EP 627
PG 9
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 648TA
UT WOS:000281715800009
PM 21033030
ER

PT J
AU Kagoya, R
   Ito, K
   Kashio, A
   Karino, S
   Yamasoba, T
AF Kagoya, Ryoji
   Ito, Ken
   Kashio, Akinori
   Karino, Shotaro
   Yamasoba, Tatsuya
TI Dislocation of Stapes With Footplate Fracture Caused by Indirect Trauma
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE footplate fracture; indirect trauma; stapes dislocation
ID HEARING-LOSS
AB We report the first case of isolated stapedial dislocation caused by indirect head trauma, and present imaging and surgical findings in the case of a 25-year-old woman who suffered hearing loss and dizziness after head trauma caused by a traffic accident. The pure tone average was 60 dB, with an air-bone gap of 50 dB. The stapedial reflex was positive with the probe on the affected ear. Computed tomography scans revealed a longitudinal fracture of the temporal bone and a dislocated stapedial superstructure in the tympanic cavity, adhering to the tympanic membrane. During surgery, it was found that the stapes was broken at the base of the posterior crus and at the anterior one third of the footplate and that the stapedial superstructure was dislocated outward and downward, with the anterior one third of the footplate adhering to the tympanic membrane. The stapedial tendon was connected to the superstructure. Ossicular chain reconstruction was performed with success. In the present case, two mechanisms may have acted together: 1) an increase in perilymphatic pressure that caused the footplate to fracture, and 2) a distorting force that broke the posterior crus, disconnecting the incudostapedial joint, and finally dislocating the stapedial superstructure together with the anterior part of the footplate.
C1 [Ito, Ken] Teikyo Univ, Dept Otolaryngol, Fac Med, Itabashi Ku, Tokyo 1738605, Japan.
   [Kagoya, Ryoji; Ito, Ken; Kashio, Akinori; Karino, Shotaro; Yamasoba, Tatsuya] Univ Tokyo, Dept Otolaryngol, Fac Med, Tokyo 113, Japan.
RP Ito, K (reprint author), Teikyo Univ, Dept Otolaryngol, Fac Med, Itabashi Ku, 2-11-1 Kaga, Tokyo 1738605, Japan.
CR AZEM K, 1973, ARCH OTOLARYNGOL, V97, P413
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NR 7
TC 2
Z9 3
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD SEP
PY 2010
VL 119
IS 9
BP 628
EP 630
PG 3
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 648TA
UT WOS:000281715800010
PM 21033031
ER

PT J
AU Kimura, Y
   Sugiura, M
   Kato, T
   Makino, N
   Ohmae, Y
   Kishimoto, S
AF Kimura, Yurika
   Sugiura, Mutsumi
   Kato, Tomofumi
   Makino, Nao
   Ohmae, Yukio
   Kishimoto, Seiji
TI Value of Barium Swallow Studies in Predicting the Response to
   Rabeprazole in Elderly Patients With Laryngopharyngeal Reflux Disease
   and Nonerosive Reflux Disease in Particular
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE barium swallow study; gastroesophageal reflux disease; laryngopharyngeal
   reflux disease; rabeprazole
ID GASTROESOPHAGEAL-REFLUX; ESOPHAGEAL MOTILITY; ACID REFLUX;
   PRESBYESOPHAGUS; PERISTALSIS
AB Objectives: Laryngopharyngeal reflux disease (LPRD) is an important cause of throat discomfort in the elderly. Our objective was to investigate the usefulness of barium swallow studies for the diagnosis of LPRD.
   Methods: The subjects were 59 patients at least 60 years of age with LPRD suspected on laryngoscopic findings. We evaluated esophageal clearance using a barium swallow study and the upper gastrointestinal tract endoscopic findings of gastroesophageal reflux disease according to the revised Los Angeles classification, and correlated these findings with the effect of rabeprazole, a proton pump inhibitor.
   Results: Among subjects with positive reflux findings in the esophageal phase of the barium swallow, rabeprazole was significantly effective (p = 0.0025). To identify nonerosive reflux disease, we analyzed the 50 cases with a negative Los Angeles classification of upper gastrointestinal tract endoscopic findings. Rabeprazole was again significantly effective in patients with positive findings for esophageal reflux (p = 0.0025).
   Conclusions: Among elderly patients with suspected LPRD, there was a positive correlation between impaired esophageal clearance on the barium swallow study and the effectiveness of rabeprazole. The barium swallow study could be a screening test for LPRD in elderly patients with throat discomfort.
C1 [Kimura, Yurika] Tokyo Metropolitan Geriatr Hosp, Dept Otolaryngol, Itabashi Ku, Tokyo 1730015, Japan.
   [Kishimoto, Seiji] Tokyo Med & Dent Univ, Grad Sch, Dept Head & Neck Surg, Tokyo, Japan.
   [Makino, Nao] Soka Municipal Hosp, Dept Otolaryngol, Saitama, Japan.
   [Ohmae, Yukio] Taisei Hosp, Dept Otolaryngol, Saitama, Japan.
RP Kimura, Y (reprint author), Tokyo Metropolitan Geriatr Hosp, Dept Otolaryngol, Itabashi Ku, 35-2 Sakaecho, Tokyo 1730015, Japan.
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NR 22
TC 1
Z9 2
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD SEP
PY 2010
VL 119
IS 9
BP 631
EP 635
PG 5
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 648TA
UT WOS:000281715800011
PM 21033032
ER

PT J
AU Fajdiga, I
   Groselj, A
   Zupevc, A
AF Fajdiga, Igor
   Groselj, Ales
   Zupevc, Avgust
TI Epiglottoplasty for Reconstruction of Defects After Laryngectomy With
   Partial Pharyngectomy
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE epiglottis; hypopharyngeal neoplasm; surgical flap
ID NEAR-TOTAL LARYNGECTOMY; EPIGLOTTIC RECONSTRUCTION
AB Objectives: We present a novel use of sliding epiglottoplasty as an alternative method for closing mucosal defects in selected laryngectomies with partial pharyngectomy.
   Methods: Sliding epiglottoplasty as described and advocated by Sedlacek, Bouche, Kambic, and Tucker for reconstruction in partial laryngectomies was used to close the defects after laryngectomy with partial pharyngectomy in 17 patients with advanced hypopharyngeal cancers as primary therapy (16 patients) and as post-radiochemotherapy therapy (1 patient).
   Results: All reconstructions were successful. Primary closures were achieved without additional morbidity, there were no pharyngocutaneous fistulas, and all patients resumed deglutition. Ten patients acquired esophageal speech, speech valves were inserted in 5 cases, and 2 patients required the use of an electrolarynx.
   Conclusions: If the oncoloaical circumstances allow its preservation in laryngectomy with partial pharyngectomy, the epiglottis is an ideal structure for closing the defect; it is a local tissue with shape, thickness, rigidity, and borders that match the recipient site. In comparison to distant pedicled or free microvascular flaps, the epiglottoplasty is a shorter procedure, requires a smaller surgical team, results in less trauma, has a lower incidence of complications, and enables faster recovery. It is surprising that this elegant, successful, and generally accepted larynx preservation procedure has not been recognized as useful for larger reconstructions.
C1 [Fajdiga, Igor; Groselj, Ales; Zupevc, Avgust] Univ Clin Otorhinolaryngol & Cervicofacial Surg, Ljubljana 1000, Slovenia.
RP Fajdiga, I (reprint author), Univ Clin Otorhinolaryngol & Cervicofacial Surg, Zaloska 2, Ljubljana 1000, Slovenia.
CR Anthony JP, 1997, HEAD NECK-J SCI SPEC, V19, P541
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NR 19
TC 0
Z9 0
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD SEP
PY 2010
VL 119
IS 9
BP 636
EP 640
PG 5
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 648TA
UT WOS:000281715800012
PM 21033033
ER

PT J
AU Alon, EE
   Ekbom, DC
AF Alon, Eran E.
   Ekbom, Dale C.
TI Neurosarcoidosis Affecting the Vagus Nerve
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT 89th Annual Meeting of the American-Broncho-Esophagological-Association
CY MAY 28-29, 2009
CL Phoenix, AZ
SP Amer Broncho-Esophagol Assoc
DE neurosarcoidosis; sarcoidosis; vagus nerve
ID SARCOIDOSIS
AB Objectives: Our objective was to review patients who presented to our medical center with a diagnosis of neurosarcoidosis affecting the vagus nerve and to present symptoms, progression, treatments, and outcome.
   Methods: We performed a chart review of patients who presented to our medical center in the past 10 years with a diagnosis of neurosarcoidosis specifically affecting cranial nerve X.
   Results: A chart review of 53 patients revealed only 4 with findings suggestive of vagal neurosarcoidosis. All were male and had a mean age of 50 years (range, 42 to 57 years) at presentation of symptoms. Two of the 4 patients presented initially with cough, I had recurrent syncope, and another presented with left facial pain. Vagus nerve involvement included vocal fold paresis or paralysis in all 4 patients, 2 of whom reported coughing with exposure to various odors and 2 of whom were found to have a unilateral palatal weakness. All but I had positive findings on magnetic resonance imaging of the head.
   Conclusions: Neurosarcoidosis involving the vagus nerve is a rare finding, but should be considered in the differential diagnosis of vocal fold paresis or paralysis.
C1 [Alon, Eran E.; Ekbom, Dale C.] Mayo Clin, Dept Otolaryngol Head & Neck Surg, Rochester, MN 55905 USA.
RP Ekbom, DC (reprint author), Mayo Clin, Dept Otolaryngol Head & Neck Surg, 200 1st St SW, Rochester, MN 55905 USA.
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   Christoforidis GA, 1999, AM J NEURORADIOL, V20, P655
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   Gullapalli D, 2002, NEUROL CLIN, V20, P59, DOI 10.1016/S0733-8619(03)00054-9
   Lury KM, 2004, SEMIN ROENTGENOL, V39, P495, DOI 10.1053/j.ro.2004.06.006
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NR 7
TC 1
Z9 1
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD SEP
PY 2010
VL 119
IS 9
BP 641
EP 645
PG 5
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 648TA
UT WOS:000281715800013
PM 21033034
ER

PT J
AU Cho, JH
   Kim, JK
   Lee, JG
   Yoon, JH
AF Cho, Jae Hoon
   Kim, Jin Kook
   Lee, Jeung-Gweon
   Yoon, Joo-Heon
TI Sphenoid Sinus Pneumatization and Its Relation to Bulging of Surrounding
   Neurovascular Structures
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE internal carotid artery; maxillary nerve; optic nerve; sphenoid sinus;
   vidian nerve
ID ANATOMIC VARIATIONS
AB Objectives: We investigated the bulging and dehiscence of neurovascular structures in the sphenoid sinus and their relationships to the pneumatization of the sphenoid sinus.
   Methods: One hundred sagittally hemisected cadaveric heads were examined. The degree of pneumatization of the sphenoid sinus was determined. Bulging and dehiscence of the internal carotid artery (ICA), optic nerve, maxillary nerve, and vidian nerve were examined, and the distances between these structures and the anterior or superior wall of the sphenoid sinus were measured. Additionally, the degree of bony thickness over these structures was determined.
   Results: The prevalences of bulging of the optic nerve, segments 1 and 3 of the ICA, and the maxillary and vidian nerves were 56%, 34%; 65%, 41%, and 52%, respectively. The greater the degree of pneumatization, the more frequently did the structures bulge into the sphenoid sinus. The optic nerve was found to be in close proximity to the anterior and superior walls of the sphenoid sinus. The bone over the surrounding structures was very thin, especially for the complete sellar type.
   Conclusions: The prevalence of bulging of the optic nerve, the ICA, and the maxillary and vidian nerves increased in proportion to the degree of sphenoid sinus pneumatization.
C1 [Yoon, Joo-Heon] Yonsei Univ, Coll Med, Dept Otorhinolaryngol, Seoul 120752, South Korea.
   [Cho, Jae Hoon; Kim, Jin Kook] Konkuk Univ, Coll Med, Dept Otorhinolaryngol Head & Neck Surg, Seoul, South Korea.
   [Yoon, Joo-Heon] Yonsei Univ, Coll Med, Airway Mucus Inst, Seoul 120752, South Korea.
   [Yoon, Joo-Heon] Yonsei Univ, Coll Med, Brain Korea Project Med Sci 21, Seoul 120752, South Korea.
RP Yoon, JH (reprint author), Yonsei Univ, Coll Med, Dept Otorhinolaryngol, 134 Shinchon Dong, Seoul 120752, South Korea.
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NR 11
TC 11
Z9 11
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD SEP
PY 2010
VL 119
IS 9
BP 646
EP 650
PG 5
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 648TA
UT WOS:000281715800014
PM 21033035
ER

PT J
AU Guevara, N
   Sterkers, O
   Bebear, JP
   Meller, R
   Magnan, J
   Mosnier, I
   Amstutz, I
   Lerosey, Y
   Triglia, JM
   Roman, S
   Gahide, I
AF Guevara, Nicolas
   Sterkers, Olivier
   Bebear, Jean-Pierre
   Meller, Renaud
   Magnan, Jacques
   Mosnier, Isabelle
   Amstutz, Isabelle
   Lerosey, Yannick
   Triglia, Jean-Michel
   Roman, Stephane
   Gahide, Ivan
TI Multicenter Evaluation of the Digisonic SP Cochlear Implant Fixation
   System With Titanium Screws in 156 Patients
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT 116th Annual Scientific Meeting of the
   French-Society-of-Otolaryngology-Head-and-Neck-Surgery
CY OCT 04-06, 2009
CL Paris, FRANCE
SP French Soc Otolaryngol Head & Neck Surg
DE cochlear implant; Digisonic SP Neurelec; fixation; minimally invasive
   treatment; surgical technique; titanium screw
ID MINIMAL ACCESS SURGERY; COMPLICATIONS; INCISION; CHILDREN; DEVICE
AB Objectives: We describe and evaluate the process of fixation of the Digisonic SP cochlear implant with two titanium screws.
   Methods: The characteristics of this implant allow cochlear implantation using a minimal incision, a subperiosteal pocket, and fixation with two titanium screws, without drilling a custom-fitted seat or creating suture-retaining holes in the skull. The fixation system relies on two tailfins for use of osseo-integratable screws, incorporated into the cochlear implant housing. The first version of this fixation system was modified after a case of device migration: the size of the titanium insert inside the silicone tailfin was increased. Data on 156 patients (8 months to 86 years of age) from a 4-year period in 6 cochlear implantation centers were retrospectively evaluated. Ten patients have undergone bilateral implantation.
   Results: Of 166 implantations, 4 postoperative infections and 1 device failure after head trauma were reported. No cerebrospinal fluid leaks or epidural hematomas were reported. One device migration was observed in the first series; no device migrations occurred in the second series.
   Conclusions: The fixation system with screws embedded in the Digisonic SP involves a fast and simple surgical technique that seems to efficiently prevent implant migration.
C1 [Guevara, Nicolas; Gahide, Ivan] Pasteur Hosp, Dept Otorhinolaryngol, Nice, France.
   [Sterkers, Olivier] Beaujon Hosp, Dept Otorhinolaryngol, Clichy, France.
   [Mosnier, Isabelle] Univ Paris 07, Paris, France.
   [Mosnier, Isabelle] Hop Louis Mourier, Dept Otorhinolaryngol, F-92701 Colombes, France.
   [Bebear, Jean-Pierre] Pellegrin Hosp, Dept Otorhinolaryngol, Bordeaux, France.
   [Meller, Renaud; Magnan, Jacques] Nord Hosp, Dept Otorhinolaryngol, Marseille, France.
   [Triglia, Jean-Michel; Roman, Stephane] La Timone Hosp, Dept Otorhinolaryngol, Marseille, France.
   [Amstutz, Isabelle; Lerosey, Yannick] Nicolle Hosp, Dept Otorhinolaryngol, Rouen, France.
RP Guevara, N (reprint author), Univ Nice, Pasteur Hosp, Dept Otolaryngol Head & Neck Surg, 30 Ave Voie Romaine,BP 69, F-06002 Nice 1, France.
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   Ray Jaydip, 2004, Cochlear Implants Int, V5, P87, DOI 10.1002/cii.132
   Stratigouleas ED, 2006, OTOLARYNG HEAD NECK, V135, P383, DOI 10.1016/j.otohns.2006.03.023
   Venail F, 2008, ARCH OTOLARYNGOL, V134, P1276, DOI 10.1001/archoto.2008.504
   Vincent C, 2008, EUR ARCH OTO-RHINO-L, V265, P1043, DOI 10.1007/s00405-007-0576-6
   Yun JM, 2005, OTOLARYNG HEAD NECK, V133, P275, DOI 10.1016/j.otohns.2005.02.018
NR 25
TC 14
Z9 14
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD AUG
PY 2010
VL 119
IS 8
BP 501
EP 505
PG 5
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 638AM
UT WOS:000280861700001
PM 20860274
ER

PT J
AU Ye, J
   Liu, H
   Zhang, GH
   Li, P
   Yang, QT
   Liu, XA
   Li, YA
AF Ye, Jin
   Liu, Hui
   Zhang, Ge-hua
   Li, Peng
   Yang, Qin-tai
   Liu, Xian
   Li, Yuan
TI Outcome of Adenotonsillectomy for Obstructive Sleep Apnea Syndrome in
   Children
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE adenoiclectomy; child; obstructive sleep apnea syndrome;
   polysomnography; quality of life; tonsillectomy
ID QUALITY-OF-LIFE; APNEA/HYPOPNEA SYNDROME; PREPUBERTAL CHILDREN; SURGICAL
   OUTCOMES; OBESE CHILDREN; METAANALYSIS; ADENOIDECTOMY; TONSILLECTOMY
AB Objectives: We evaluated the outcome of adenotonsillectomy for obstructive sleep apnea syndrome (OSAS) in children using polysomnography (PSG) data and a quality-of-life (QOL) instrument.
   Methods: We enrolled children (4 to 14 years of age) who had OSAS diagnosed by overnight PSG and who underwent both adenoidectomy and tonsillectomy between January 2003 and February 2008. All of them had completed postoperative PSG and a paired Obstructive Sleep Apnea 18-Item Quality-of-Life Questionnaire (OSA-18) survey. The statistical analyses were performed with a statistical software package.
   Results: The study included 84 children with a mean age of 7.1 years. The mean preoperative apnea-hypopnea index (AHI) for the study population was 24.6, and the mean postoperative AHI was 3.8 episodes per hour. The percentage of children who had normal PSG parameters after adenotonsillectomy ranged from 69.0% to 86.9% because of fluctuation of the criteria used to define OSAS. Nine children (30%) with severe preoperative OSAS had persistent OSAS (an AHI of at least 5) after surgery. Improvements in QOL were comparable in the cured and not-cured groups (p > 0.05). Risk factors for persistent OSAS were obesity and a high preoperative AHI, on multiple logistic regression analysis.
   Conclusions: Adenotonsillectomy is associated with improvements in PSG, behavior, and QOL in children with OSAS. However, it may not resolve OSAS in all children. The efficacy and role of additional therapeutic options require more study.
C1 [Ye, Jin; Zhang, Ge-hua; Li, Peng; Yang, Qin-tai; Liu, Xian; Li, Yuan] Sun Yat Sen Univ, Affiliated Hosp 3, Dept Sleep Study & Otolaryngol Head & Neck Surg, Guangzhou 510630, Guangdong, Peoples R China.
   [Liu, Hui] Sun Yat Sen Univ, Affiliated Hosp 3, Dept Resp Dis, Guangzhou 510630, Guangdong, Peoples R China.
RP Ye, J (reprint author), Sun Yat Sen Univ, Affiliated Hosp 3, Dept Otolaryngol Head & Neck Surg, Sleep Study Ctr, 600 Tianhe St, Guangzhou 510630, Guangdong, Peoples R China.
CR Amin RS, 2002, AM J RESP CRIT CARE, V165, P1395, DOI 10.1164/rccm.2105118
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NR 29
TC 21
Z9 22
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD AUG
PY 2010
VL 119
IS 8
BP 506
EP 513
PG 8
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 638AM
UT WOS:000280861700002
PM 20860275
ER

PT J
AU Pandya, Y
   Piccirillo, E
   Mancini, F
   Sanna, M
AF Pandya, Yash
   Piccirillo, Enrico
   Mancini, Fernando
   Sanna, Mario
TI Management of Complex Cases of Petrous Bone Cholesteatoma
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE dura; facial nerve; internal carotid artery; jugular bulb; lower cranial
   nerve; petrous bone cholesteatoma
ID TRANSCOCHLEAR APPROACH; FACIAL-NERVE; SKULL BASE
AB Objectives: In a retrospective analysis of a quaternary referral neuro-otologic private practice, we identify complex cases of petrous bone cholesteatoma (ie. cases with encasement of vital structures such as the internal carotid artery, jugular bulb, and siemoid sinus, with further extension to the clivus, sphenoid sinus, or rhinopharynx), review surgical approaches and techniques of management of vital structures, and propose the ideal surgical management.
   Methods: We performed a retrospective case study of 130 cases of petrous bone cholesteatoma submitted to surgery between 1979 and 2009 to identify the complex cases and their classification, approach used, outcomes, and recurrences.
   Results: Of 130 cases, 13 were complex. Facial palsy was the presenting feature in 11 cases, 7 of which presented with grade VI palsy. A long duration of facial palsy (more than 3 years) was seen in 5 cases. Clival involvement was seen in 6 cases: 1 case extended to the sphenoid sinus, and 1 to the rhinopharynx. The internal carotid artery was encased in 11 cases in the vertical and the horizontal parts. The jugular bulb was involved in 7 cases. Modified transcochlear approaches or infratemporal fossa approaches were used in all cases. There were no recurrences.
   Conclusions: Classification is fundamental to choosing the right surgical approach. Transotic and modified transcochlear approaches hold the key to treating complex cases. Infratemporal fossa approach type B has to be used for extension into the clivus, sphenoid sinus, or rhinopharynx. Internal carotid artery, jugular bulb, and siemoid sinus involvement should be identified before operation.
C1 [Pandya, Yash; Piccirillo, Enrico; Mancini, Fernando; Sanna, Mario] Casa Cura, Grp Otol, I-29100 Piacenza, Italy.
RP Pandya, Y (reprint author), Casa Cura, Grp Otol, Via Emanueli 42, I-29100 Piacenza, Italy.
FU Association Italiana Neurootologica
FX From the Gruppo Otologico, Casa Di Cura, Piacenza, Italy. Supported by a
   grant from the Association Italiana Neurootologica.
CR Axon PR, 1999, AM J OTOL, V20, P505
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NR 10
TC 3
Z9 3
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD AUG
PY 2010
VL 119
IS 8
BP 514
EP 525
PG 12
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 638AM
UT WOS:000280861700003
PM 20860276
ER

PT J
AU Casserly, P
   Kieran, S
   Phelan, E
   Smyth, E
   Lacy, P
AF Casserly, Paula
   Kieran, Stephen
   Phelan, Eimear
   Smyth, Edmond
   Lacy, Peter
TI Bacteremia During Adenoidectomy: A Comparison of Suction Diathermy
   Adenoid Ablation and Adenoid Curettage
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE adenoidectomy; antibiotic prophylaxis; bacteremia; child
ID POST-TONSILLECTOMY BACTEREMIA; PEDIATRIC ADENOIDECTOMY; CHILDREN
AB Objectives: Transient bacteremia is induced by adenoidectomy when the integrity of the nasopharyngeal membrane is broken. The aim of this study was to determine the incidence of bacteremia in patients undergoing adenoidectomy, to identify the causative organisms, and to compare the incidences of bacteremia between the two techniques suction diathermy and curettage.
   Methods: A prospective single-blind randomized trial was performed. Sixty-four patients between the ages of 2 and 13 years who were undergoing adenoidectomy were included in the study. Exclusion criteria included antimicrobial therapy in the immediate preoperative period and concurrent respiratory tract infection or pyrexia. Patients were randomized in the anesthetic room to either suction diathermy or curettage. Venous blood samples for culture were obtained 30 seconds after the procedure began (intraoperative sample) and 2 minutes after removal of the adenoid tissue (postoperative sample). Postoperative complications were recorded, and all patients were followed in the outpatient department.
   Results: Twenty-six patients underwent adenoidectomy by suction diathermy, and 38 underwent adenoidectomy by curettage. In the suction diathermy group, 38.5% of intraoperative and 19.2% of postoperative blood cultures had a positive result for bacteremia. In the curettage group, 31.6% of intraoperative and 23.6% of postoperative blood cultures had a positive result for bacteremia. There was no significant difference between the two groups. The techniques were equivalent in terms of postoperative complications. Gram-positive cocci were the most commonly isolated organisms.
   Conclusions: A transient bacteremia exists after pediatric adenoidectomy, but does not correlate with symptoms or signs. Neither suction diathermy adenoidectomy nor curettage adenoidectomy offers a particular advantage in terms of decreasing the incidence of bacteremia.
C1 [Casserly, Paula; Kieran, Stephen; Phelan, Eimear; Lacy, Peter] Beaumont Hosp, Dept Otolaryngol Head & Neck Surg, Dublin 9, Ireland.
   [Smyth, Edmond] Beaumont Hosp, Dept Clin Microbiol, Dublin 9, Ireland.
RP Casserly, P (reprint author), 16 Newbridge Ave, Dublin 4, Ireland.
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NR 18
TC 1
Z9 1
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD AUG
PY 2010
VL 119
IS 8
BP 526
EP 529
PG 4
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 638AM
UT WOS:000280861700004
PM 20860277
ER

PT J
AU Sayed, RH
   Abu-Dief, EE
   Mohamed, DS
AF Sayed, Ramadan Hashem
   Abu-Dief, Eman E.
   Mohamed, Doha S.
TI Do Viscid Secretions Have a Role in Nasal Polyp Formation?
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE nasal polyp; secretion; sinusitis without polyposis; viscid secretion
ID PATHOGENESIS; FIBROBLASTS; EPITHELIUM; EXPRESSION
AB Objectives: We compared histologic findings on light microscopy of viscid secretions found in association with nasal polyps with those found in patients with chronic sinusitis without polyposis (CSWP). The differences might further understanding of nasal polyp pathogenesis.
   Methods: In a prospective controlled study, viscid secretions found in association with nasal polyps were collected at endoscopic sinus surgery. Retained secretions in patients with CSWP acted as a control group. Both were fixed in 10% formalin, processed, and examined with a light microscope.
   Results: Viscid secretions were encountered among nasal polyps in 25 of 132 patients (18.9%). Polyps containing multiloculated cysts filled with viscid secretions were found in 2 of them. Histologic examination of viscid secretions showed variable histologic pictures, ranging from a homogeneous material infiltrated with inflammatory cells, newly formed blood vessels, and bundles of collagen fibers to a well-developed connective tissue core covered with a respiratory epithelium in some areas. Histologic examination of retained secretions in patients with CSWP revealed amorphous material infiltrated with inflammatory cells with no further maturation or epithelial coverage.
   Conclusions: Viscid secretions, originating from ruptured mucosal cysts, might represent the initial step in nasal polyp pathogenesis. The variable histologic pictures detected possibly reflect different stages in nasal polyp formation from these secretions. Factors postulated in nasal polyp etiopathogenesis might trigger maturation and changes in the morphological structure of these secretions.
C1 [Sayed, Ramadan Hashem] Sohag Univ, Sohag Fac Med, Dept Otorhinolaryngol, Sohag, Egypt.
   [Abu-Dief, Eman E.; Mohamed, Doha S.] Sohag Univ, Sohag Fac Med, Dept Histol, Sohag, Egypt.
RP Sayed, RH (reprint author), Sohag Fac Med, ENT Dept, Sohag, Egypt.
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NR 30
TC 0
Z9 0
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD AUG
PY 2010
VL 119
IS 8
BP 530
EP 534
PG 5
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 638AM
UT WOS:000280861700005
PM 20860278
ER

PT J
AU Ochi, N
   Doi, K
   Uranagase, M
   Nishikawa, T
   Katsunuma, S
   Nibu, K
AF Ochi, Naoki
   Doi, Kiyoshi
   Uranagase, Masahiro
   Nishikawa, Tasuku
   Katsunuma, Sayaka
   Nibu, Ken-ichi
TI Bone Marrow Stem Cell Transplantation to Olfactory Epithelium
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE bone marrow stem cell; bulbectomy; olfactory epithelium; transplantation
ID NERVE GROWTH-FACTOR; EXPRESSION; MOUSE; DIFFERENTIATE; NEURONS; MATURE;
   BRAIN
AB Objectives: We sought to develop a new therapeutic strategy for degeneration of olfactory receptor neurons (ORNs).
   Methods: We transplanted into Balb/C mice, locally by transnasal injection and systemically via the tail vain, BrdU-labeled bone marrow stem cells, also known as NRGs, which have the ability to differentiate into neural cells. Bone marrow stem cells engrafted into the olfactory epithelium were examined immunohistochemically.
   Results: Compared with previous studies, in which bone marrow was transplanted rather than bone marrow stem cells, migration of transplanted bone marrow stem cells into the olfactory epithelium was observed earlier, and engraftment rates were significantly higher. However, migrated bone marrow stem cells were positive for GAP43 but not for olfactory marker protein.
   Conclusions: These results suggest that engrafted cells had differentiated into premature, but not mature, ORNs. Further experiments using autologous bone marrow stem cells in combination with various growth factors and/or neurotrophic factors should aid the development of new therapeutic methods for degenerated ORNs.
C1 [Ochi, Naoki; Doi, Kiyoshi; Uranagase, Masahiro; Nishikawa, Tasuku; Katsunuma, Sayaka; Nibu, Ken-ichi] Kobe Univ, Dept Otolaryngol Head & Neck Surg, Grad Sch Med, Chuo Ku, Kobe, Hyogo 6500017, Japan.
RP Nibu, K (reprint author), Kobe Univ, Dept Otolaryngol Head & Neck Surg, Grad Sch Med, Chuo Ku, 7-5-1 Kusunoki Cho, Kobe, Hyogo 6500017, Japan.
FU Ministry of Education, Culture, Sports, Science and Technology of the
   Japanese Government [18390458]
FX From the Department of Otolaryngology Head and Neck Surgery, Kobe
   University Graduate School of Medicine, Kobe, Japan. This work was
   partly supported by a grant from the Ministry of Education, Culture,
   Sports, Science and Technology of the Japanese Government (18390458) to
   Dr Nibu.
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   Yasuno H, 2000, BRAIN RES, V887, P53, DOI 10.1016/S0006-8993(00)02966-8
NR 25
TC 0
Z9 0
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD AUG
PY 2010
VL 119
IS 8
BP 535
EP 540
PG 6
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 638AM
UT WOS:000280861700006
PM 20860279
ER

PT J
AU Songu, M
   Adibelli, ZH
   Tuncyurek, O
   Adibelli, H
AF Songu, Murat
   Adibelli, Zebra H.
   Tuncyurek, Ozum
   Adibelli, Hamit
TI Age-Specific Size of the Upper Airway Structures in Children During
   Development
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE age-specific size; child; development; magnetic resonance imaging;
   obstructive sleep apnea; sleep-disordered breathing; upper airway
ID OBSTRUCTIVE SLEEP-APNEA; ADENOTONSILLAR HYPERTROPHY; ADENOIDS;
   DIMENSIONS
AB Objectives: The purpose of this study was to establish the largest magnetic resonance imaging study so far, by including 292 cases in a prospective fashion, to investigate the normative values of the upper airway and surrounding tissues during development.
   Methods: We enrolled in the study 448 children who underwent cranial magnetic resonance imaging. We included 292 patients who had no sleep disorders or any associated symptom that could be related to breathing disorders. Using midsagittal and axial images, we evaluated the variations in size of the upper airway tissues.
   Results: On images from the midsagittal plane, the normative values of the length and the thickness of the soft palate, the length and height of the tongue, the distance between the mental spine and the clivus, the thickness of the adenoid pad and the nasopharyngeal area, the adenoid pad oblique width, the soft palate oblique width, and the tongue oblique width were obtained for several age groups. Using images from the axial plane at the level of maximal tonsillar cross-sectional area, we measured the normative values of the mean tonsillar width and intertonsillar space.
   Conclusions: Magnetic resonance imaging is an excellent method of assessing upper airway structures. Knowledge of variations in size of the upper airway and surrounding tissues is essential in determining the significance of incidental findings in this area.
C1 [Songu, Murat; Adibelli, Hamit] Dr Behcet Uz Childrens Hosp, Dept Otorhinolaryngol, Izmir, Turkey.
   [Songu, Murat] Izmir Ataturk Res & Training Hosp, Dept Otorhinolaryngol, Izmir, Turkey.
   [Adibelli, Zebra H.] Izmir Bozyaka Res & Training Hosp, Dept Radiol, Izmir, Turkey.
   [Tuncyurek, Ozum] Ataturk Govt Hosp, Dept Radiol, Aydin, Turkey.
RP Songu, M (reprint author), Dr Behcet Uz Childrens Hosp, Dept Otorhinolaryngol, Izmir, Turkey.
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NR 23
TC 1
Z9 3
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD AUG
PY 2010
VL 119
IS 8
BP 541
EP 546
PG 6
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 638AM
UT WOS:000280861700007
PM 20860280
ER

PT J
AU Johnston, N
   Wells, CW
   Samuels, TL
   Blumin, JH
AF Johnston, Nikki
   Wells, Clive W.
   Samuels, Tina L.
   Blumin, Joel H.
TI Rationale for Targeting Pepsin in the Treatment of Reflux Disease
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE laryngopharyngeal reflux; pepsin; reflux
ID LARYNGOPHARYNGEAL REFLUX; GASTROESOPHAGEAL-REFLUX; EPITHELIAL-CELLS;
   SYMPTOMS; IMPEDANCE; FUNDOPLICATION; ACID; MACROPINOCYTOSIS;
   ESOMEPRAZOLE; COMPARTMENT
AB Objectives: We undertook to 1) obtain unequivocal evidence to confirm or rebut our initial observations that pepsin is taken up by hypopharyngeal epithelial cells by receptor-mediated endocytosis, 2) investigate whether uptake of pepsin at pH 7, in nonacidic refluxate, is of pathological significance, and 3) test our hypothesis that inactive but stable pepsin (<pH 8) taken up by hypopharyngeal epithelial cells causes damage by becoming reactivated inside the cell.
   Methods: Human posterior cricoid biopsy specimens and cultured hypopharyngeal FaDu epithelial cells were used to perform competitive binding studies and to investigate colocalization of pepsin with clathrin, Rab-9, and TRG-46. FaDu cells were exposed to pepsin (both irreversibly and reversibly inactivated) in the presence and absence of wortmannin and dimethyl amiloride and analyzed by electron microscopy, MTT cytotoxicity assay, and Stress and Toxicity SuperArray.
   Results: Pepsin is unequivocally taken up by hypopharyngeal epithelial cells by receptor-mediated endocytosis. Uptake of pepsin at pH 7, in nonacidic refluxate, causes mitochondrial damage and changes the expression of several genes implicated in stress and toxicity. Irreversible, but not reversible, inhibition of peptic activity prevents these changes.
   Conclusions: Pepsin, at pH 7, in nonacidic refluxate, causes damage by becoming reactivated inside the cell. Irreversible inhibitors of peptic activity hold promise as a new therapy for reflux.
C1 [Johnston, Nikki; Samuels, Tina L.; Blumin, Joel H.] Med Coll Wisconsin, Dept Otolaryngol & Commun Sci, Milwaukee, WI 53226 USA.
   [Wells, Clive W.] Med Coll Wisconsin, Dept Microbiol & Mol Genet, Milwaukee, WI 53226 USA.
RP Johnston, N (reprint author), Med Coll Wisconsin, Dept Otolaryngol & Commun Sci, 9200 W Wisconsin Ave, Milwaukee, WI 53226 USA.
FU Department of Otolaryngology and Communication Sciences, Medical College
   of Wisconsin, Milwaukee, Wisconsin
FX From the Departments of Otolaryngology and Communication Sciences
   (Johnston, Samuels, Blumin) and Microbiology and Molecular Genetics
   (Wells), Medical College of Wisconsin, Milwaukee, Wisconsin. This
   research study was sponsored by the Department of Otolaryngology and
   Communication Sciences, Medical College of Wisconsin, Milwaukee,
   Wisconsin.
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NR 34
TC 11
Z9 11
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD AUG
PY 2010
VL 119
IS 8
BP 547
EP 558
PG 12
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 638AM
UT WOS:000280861700008
PM 20860281
ER

PT J
AU Grisel, J
   Khosla, S
   Murugappan, S
   Lakhamraju, R
   Aubry, J
   Gutmark, E
   Huntress, G
AF Grisel, Jedidiah
   Khosla, Sid
   Murugappan, Shanmugam
   Lakhamraju, Raghava
   Aubry, James
   Gutmark, Ephraim
   Huntress, Gordon
TI How Does the Absence or Presence of Subglottal Medialization Affect
   Glottal Airflow?
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT 89th Annual Meeting of the American-Broncho-Esophagological-Association
CY MAY 28-29, 2009
CL Phoenix, AZ
SP Amer Broncho Esophagol Assoc
DE larynx; phonation; vocal fold; voice
ID THYROPLASTY TYPE-I; VOICE QUALITY; CONTRACTION; PHONATION; TURBULENCE;
   MODEL; SHAPE
AB Objectives: Our previous work has shown that the symmetric, smooth, convergent shape of the subglottis reduces turbulent airflow at the glottal entrance. Medialization thyroplasty may alter the glottal shape and is very likely to introduce some degree of glottal asymmetry, which could result in increased turbulence and a reduction in voice quality. This study reports the effects of medializing and not medializing the subglottis in silicone models of human cadaveric larynges.
   Methods: In experiment 1, silicone models of 4 human cadaveric larynges were created. The subglottis was then completely medialized in all 4 models. Hot-wire anemometry was used to measure velocity and turbulence profiles at the entrance and exit of the subglottis. In experiment 2, 1 model was created to accommodate incremental medialization of the glottis without any medialization of the subglottis. Airflow characteristics were likewise measured.
   Results: In experiment 1, the average maximum turbulence intensity (TI) at the exit of the larynx was less than the TI of incoming tracheal airflow for all 4 larynges. In experiment 2, incremental medialization of the glottis did not affect the TI for medialization up to 35%. However, the TI significantly increased for medialization of 53%.
   Conclusions: Medialization of the subglottis does not significantly affect the turbulence reduction properties of the subglottis, even though subglottal asymmetry is introduced. On the other hand, large amounts of medialization of the glottis only (with no subglottal medialization) can introduce significant amounts of turbulence.
C1 [Grisel, Jedidiah; Khosla, Sid; Murugappan, Shanmugam; Aubry, James; Gutmark, Ephraim; Huntress, Gordon] Univ Cincinnati, Med Ctr, Dept Otolaryngol Head & Neck Surg, Cincinnati, OH 45267 USA.
   [Lakhamraju, Raghava; Gutmark, Ephraim] Univ Cincinnati, Dept Aerosp Engn & Engn Mech, Cincinnati, OH 45267 USA.
RP Khosla, S (reprint author), Univ Cincinnati, Med Ctr, Dept Otolaryngol Head & Neck Surg, 231 Albert B Sabin Way,ML 0528, Cincinnati, OH 45267 USA.
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NR 22
TC 4
Z9 4
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD AUG
PY 2010
VL 119
IS 8
BP 559
EP 566
PG 8
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 638AM
UT WOS:000280861700009
PM 20860282
ER

PT J
AU Hoshikawa, H
   Mori, T
   Mori, N
AF Hoshikawa, Hiroshi
   Mori, Terushige
   Mori, Nozomu
TI In Vitro and In Vivo Effects of D-Allose: Up-Regulation of
   Thioredoxin-Interacting Protein in Head and Neck Cancer Cells
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE D-allose; head and neck cancer; thioredoxin-interacting protein
ID HEPATOCELLULAR-CARCINOMA; VDUP1; GROWTH; CHEMOTHERAPY; P27(KIP1);
   HEXOSE; TXNIP
AB Objectives: This study was aimed to investigate the relationship between the antiproliferative effects of D-allose and the up-regulation of thioredoxin-interacting protein (TXNIP) in head and neck cancer cells.
   Methods: For the in vitro study, 5 oral squamous cell carcinoma cell lines (Ca9-22, HSC-3, HSC-4, SAS, and KON) were treated with 25 mmol/L D-allose. For the in vivo study, HSC-3 cells were used in a xenograft model with female athymic nude mice (BALB/c nu/nu; 5 to 6 weeks old).
   Results: Inhibition of cell growth by D-allose was noted in HSC-3 and Ca9-22 cells, along with significant induction of TXNIP. Although TXNIP up-regulation was also evident, albeit to a lesser extent, in the remaining cell lines, D-allose did not inhibit their growth. With the HSC-3 line, the cell survival fractions decreased and TXNIP expression increased in a D-allose dose dependent manner. The antiproliferative effects were partially suppressed by concomitant D-glucose treatment, which also reduced TXNIP expression. In the in vivo experiment, the tumor volume at day 15 after D-allose treatment was reduced to 61% of that of the control group.
   Conclusions: This study showed that D-allose exerts growth inhibitory effects on head and neck cancer cells in vitro and in vivo. The sugar may act as an antiproliferative agent via TXNIP induction and thus may be useful as a novel anticancer drug.
C1 [Hoshikawa, Hiroshi; Mori, Terushige; Mori, Nozomu] Kagawa Univ, Fac Med, Dept Otolaryngol, Kita, Japan.
RP Hoshikawa, H (reprint author), Kagawa Univ, Fac Med, Dept Otolaryngol, Miki, Kagawa, Japan.
FU Ministry of Education, Culture, Sports, Science and Technology, Japan
   [20592019]
FX From the Department of Otolaryngology. Faculty of Medicine, Kagawa
   University, Kita, Japan. This work was supported by a Grant-in-Aid for
   General Scientific Research (grant 20592019) from the Ministry of
   Education, Culture, Sports, Science and Technology, Japan.
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NR 24
TC 5
Z9 7
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD AUG
PY 2010
VL 119
IS 8
BP 567
EP 571
PG 5
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 638AM
UT WOS:000280861700010
PM 20860283
ER

PT J
AU Gill, MT
   Cotelingam, JD
   Lowery-Nordberg, M
   Nathan, CAO
AF Gill, Matthew T.
   Cotelingam, James D.
   Lowery-Nordberg, Mary
   Nathan, Cherie-Ann O.
TI Tracheal Non-Hodgkin's Lymphoma Masquerading as Benign Granulation
   Tissue: A Report of Two Cases
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT 89th Annual Meeting of the American-Broncho-Esophagological-Association
CY MAY 28-29, 2009
CL Phoenix, AZ
SP Amer Broncho Esophagol Assoc
DE airway compromise; granulation tissue; non-Hodgkin's lymphoma; tracheal
   lymphoma; tracheal stenosis
ID LONG-TERM SURVIVAL; SUBGLOTTIC STENOSIS; CELL LYMPHOMA; PATIENT;
   PATHOGENESIS
AB Primary tracheal non-Hodgkin's lymphoma (NHL) is rare, with fewer than 30 cases reported to date. We review the clinical presentation, evaluation, and treatment of 2 cases of tracheal NHL mimicking granulation tissue. The first patient was a 67-year-old man with myelodysplastic syndrome and Crohn's disease who had a recurring lesion of the proximal trachea causing significant airway obstruction. The second patient was a 47-year-old man with a history of multiple intubations who presented with dyspnea and stridor due to circumferential tracheal stenosis. In both cases, bronchoscopy revealed abundant granulation tissue, and the initial biopsy results indicated benign disease. However, after requests from the diagnostic team to rule out lymphoma, additional immunohistochemical stains and polymerase chain reaction testing confirmed NHL. Radiotherapy was initiated. The first patient responded well and remains disease-free after 4 years. The second patient died of airway obstruction due to severe distal tracheal stenosis. Recurrent granulation tissue should raise the suspicion of malignancy and prompt further tissue evaluation for evidence of lymphoma. Steroids for airway compromise may cause progression to mature stenosis as prednisone is used in the treatment of lymphoma. Localized disease involving the central airways may be treated successfully with limited chemotherapy and radiotherapy.
C1 [Gill, Matthew T.; Nathan, Cherie-Ann O.] Louisiana State Univ, Hlth Sci Ctr, Dept Otolaryngol Head & Neck Surg, Shreveport, LA 71105 USA.
   [Cotelingam, James D.; Lowery-Nordberg, Mary] Louisiana State Univ, Hlth Sci Ctr, Dept Pathol, Shreveport, LA 71105 USA.
   [Lowery-Nordberg, Mary; Nathan, Cherie-Ann O.] Feist Weiller Canc Ctr, Shreveport, LA USA.
RP Gill, MT (reprint author), 1501 Kings Highway, Shreveport, LA 71130 USA.
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NR 19
TC 1
Z9 1
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD JUL
PY 2010
VL 119
IS 7
BP 431
EP 435
PG 5
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 627WP
UT WOS:000280075000001
PM 20734962
ER

PT J
AU Hatten, K
   Gulleth, Y
   Meyer, T
   Eisenman, DJ
AF Hatten, Kyle
   Gulleth, Yusuf
   Meyer, Tanya
   Eisenman, David J.
TI Myiasis of the External and Middle Ear
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE myiasis; otalgia; otorrhea; tinnitus; tympanoplasty
ID AURAL MYIASIS
AB Aural myiasis is a rare otolaryngological disease typically seen in poor hygienic conditions and medically disabled patients. We present a case of aural myiasis in a healthy woman who had no apparent risk factors for infestation and required extensive surgical intervention. We also discuss the literature of documented otolaryngological cases of myiasis and effective therapies. In our patient, symptoms of otalgia, otorrhea, and tinnitus resolved after multiple attempts at extraction resulted in successful eradication of larvae. The patient required tympanoplasty to reconstruct the damaged external and middle ear. Physicians should have a clinical suspicion of aural myiasis in patients with a travel history and an atypical presentation of acute otalgia and otorrhea.
C1 [Hatten, Kyle; Gulleth, Yusuf; Meyer, Tanya; Eisenman, David J.] Univ Maryland, Sch Med, Dept Otorhinolaryngol Head & Neck Surg, Baltimore, MD 21201 USA.
RP Eisenman, DJ (reprint author), Univ Maryland, Sch Med, Dept Otorhinolaryngol Head & Neck Surg, 16 S Eutaw St, Baltimore, MD 21201 USA.
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NR 9
TC 2
Z9 2
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD JUL
PY 2010
VL 119
IS 7
BP 436
EP 438
PG 3
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 627WP
UT WOS:000280075000002
PM 20734963
ER

PT J
AU Kimura, M
   Imagawa, H
   Nito, T
   Sakakibara, KI
   Chan, RW
   Tayama, N
AF Kimura, Miwako
   Imagawa, Hiroshi
   Nito, Takaharu
   Sakakibara, Ken-Ichi
   Chan, Roger W.
   Tayama, Niro
TI Arytenoid Adduction for Correcting Vocal Fold Asymmetry: High-Speed
   Imaging
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE arytenoid adduction; diplophonia; fundamental frequency; high-speed
   imaging; vocal fold paralysis
ID VIBRATION; PARALYSIS; MODEL; KYMOGRAPHY; INJECTION; DYNAMICS
AB Objectives: We hypothesized that high-speed digital imaging provides a quantitative method to evaluate the effect of arytenoid adduction for the correction of asymmetric and irregular vocal fold vibration in unilateral vocal fold paralysis.
   Methods: Six subjects with unilateral vocal fold paralysis participated in the study (4 male, 2 female; mean [+/-SD] age, 52.5 +/- 21.3 years). Videokymographic and laryngotopographic methods for image analysis were performed for highspeed recordings of vocal fold vibration for visualizing the glottal vibratory patterns, and for quantifying the frequency of vibration of each vocal fold, respectively. Comparisons of the paralyzed and the normal vocal folds were made before and after arytenoid adduction.
   Results: Analysis of the laryngotopographs revealed 2 distinct frequencies of vibration for the paralyzed and the contralateral vocal folds for all subjects before surgery. After arytenoid adduction, the vibration frequencies became identical or nearly identical in all subjects.
   Conclusions: Asymmetric vibration in vocal fold paralysis was exemplified by differences in vibration frequency between the vocal folds. The present data showed that after arytenoid adduction the vibration frequencies and the vibratory patterns of the contralateral vocal folds approached symmetry. This surgical procedure could improve the functional symmetry of the larynx for phonation.
C1 [Kimura, Miwako; Chan, Roger W.] Univ Texas SW Med Ctr Dallas, Dept Otolaryngol Head & Neck Surg, Dallas, TX 75390 USA.
   [Chan, Roger W.] Univ Texas SW Med Ctr Dallas, Dept Biomed Engn, Dallas, TX 75390 USA.
   [Kimura, Miwako; Tayama, Niro] Univ Tokyo, Dept Otolaryngol, Int Med Ctr Japan, Tokyo 113, Japan.
   [Imagawa, Hiroshi; Nito, Takaharu; Tayama, Niro] Univ Tokyo, Dept Otorhinolaryngol Head & Neck Surg, Tokyo, Japan.
   [Sakakibara, Ken-Ichi] Hlth Sci Univ Hokkaido, Dept Commun Disorders, Sapporo, Hokkaido, Japan.
RP Kimura, M (reprint author), Univ Texas SW Med Ctr Dallas, Dept Otolaryngol Head & Neck Surg, 5323 Harry Hines Blvd, Dallas, TX 75390 USA.
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NR 27
TC 7
Z9 8
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD JUL
PY 2010
VL 119
IS 7
BP 439
EP 446
PG 8
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 627WP
UT WOS:000280075000003
PM 20734964
ER

PT J
AU Hol, MKS
   Kunst, SJW
   Snik, AFM
   Bosman, AJ
   Mylanus, EAM
   Cremers, CWRJ
AF Hol, Myrthe K. S.
   Kunst, Sylvia J. W.
   Snik, Ad F. M.
   Bosman, Arian J.
   Mylanus, Emmanuel A. M.
   Cremers, Cor W. R. J.
TI Bone-Anchored Hearing Aids in Patients With Acquired and Congenital
   Unilateral Inner Ear Deafness (Baha CROS): Clinical Evaluation of 56
   Cases
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE Baha CROS; unilateral deafness
ID AMPLIFICATION; SATISFACTION; BENEFIT; SPEECH
AB Objectives: We performed an evaluation of the audiological and subjective benefits of the bone-anchored hearing aid (Baha) as a device for transcranial routing of sound (Baha CROS) in 56 patients with unilateral inner car deafness.
   Methods: We performed a prospective clinical follow-up study in a tertiary referral center. Previously reported results of 29 patients were supplemented with a second series of 30 patients with unilateral inner ear deafness; 3 patients dropped out during the evaluation. Audiometric measurements were taken before and after Balm CROS fitting. Subjective benefits were quantified with 4 different patient questionnaires.
   Results: The sound localization results in a well-structured test setting were not differentiable from chance. The 5 patients with congenital hearing loss showed better scores in the unaided sound localization measurements. Overall, most patients reported some subjective improvement in their capacity to localize sounds with the Baha CROS in daily life. The main effect of the Baha CROS was to alleviate the head shadow effect during the speech-in-noise test.
   Conclusions: Poor sound localization in this larger series of patients confirms the findings of previous studies. Improvements in the speech-in-noise scores corroborated the efficacy of the Balm CROS in alleviating the head shadow effect. The 4 different patient questionnaires revealed subjective benefit and satisfaction in various domains.
C1 [Hol, Myrthe K. S.; Kunst, Sylvia J. W.; Snik, Ad F. M.; Bosman, Arian J.; Mylanus, Emmanuel A. M.; Cremers, Cor W. R. J.] Radboud Univ Nijmegen, Ctr Med, Dept Otorhinolaryngol, NL-6500 HB Nijmegen, Netherlands.
RP Hol, MKS (reprint author), Radboud Univ Nijmegen, Ctr Med, Dept Otorhinolaryngol, POB 9101, NL-6500 HB Nijmegen, Netherlands.
RI Mylanus, Emmanuel/D-2255-2010; Snik, Ad/H-8092-2014
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NR 22
TC 15
Z9 16
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD JUL
PY 2010
VL 119
IS 7
BP 447
EP 454
PG 8
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 627WP
UT WOS:000280075000004
PM 20734965
ER

PT J
AU Tosun, F
   Arslan, HH
   Karslioglu, Y
   Deveci, MS
   Durmaz, A
AF Tosun, Fuat
   Arslan, Hasan Huseyin
   Karslioglu, Yildirim
   Deveci, M. Salih
   Durmaz, Abdullah
TI Relationship Between Postoperative Recurrence Rate and Eosinophil
   Density of Nasal Polyps
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE eosinophil; nose; polyp; recurrence
ID ENDOSCOPIC SINUS SURGERY; SURGICAL-TREATMENT; FOLLOW-UP
AB Objectives: Nasal polyps develop as a result of chronic inflammation, mostly accompanied by pronounced eosinophil leukocyte infiltration. In this study we aimed to investigate the relationship between eosinophil density in nasal polyps and the postoperative recurrence rate of this disease.
   Methods: Forty-two patients who underwent endoscopic sinus surgery for massive nasal polyposis by one surgeon were included in the study. The eosinophil leukocyte densities in nasal polyps were determined retrospectively on histologic slides by use of computer-assisted image analysis software. The patients were assigned to group 1, in whom nasal polyps contained up to 3 eosinophils per 1,000 mu m(2), and group 2, in whom nasal polyps contained 4 or more eosinophils per 1,000 mu m(2). The postoperative recurrence rates of nasal polyps were compared in the two groups.
   Results: There were 20 patients in group 1 and 22 patients in group 2. Postoperative polyp recurrence was detected in 5 of 20 patients (25.0%) in group 1 and in 18 of 22 patients (81.8%) in group 2 during the 30-month postoperative follow-up period (p < 0.05).
   Conclusions: The eosinophil density of nasal polyps can be used to get an estimate of the postoperative recurrence risk. Eosinophil-rich nasal polyps have a higher postoperative recurrence rate.
C1 [Tosun, Fuat; Arslan, Hasan Huseyin; Durmaz, Abdullah] Gulhane Mil Med Acad, Dept Otorhinolaryngol Head & Neck Surg, TR-06018 Ankara, Turkey.
   [Karslioglu, Yildirim; Deveci, M. Salih] Gulhane Mil Med Acad, Dept Pathol, TR-06018 Ankara, Turkey.
RP Tosun, F (reprint author), Gulhane Mil Med Acad, Dept Otorhinolaryngol Head & Neck Surg, TR-06018 Ankara, Turkey.
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NR 19
TC 13
Z9 14
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD JUL
PY 2010
VL 119
IS 7
BP 455
EP 459
PG 5
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 627WP
UT WOS:000280075000005
PM 20734966
ER

PT J
AU Sauder, C
   Roy, N
   Tanner, K
   Houtz, DR
   Smith, ME
AF Sauder, Cara
   Roy, Nelson
   Tanner, Kristine
   Houtz, Daniel R.
   Smith, Marshall E.
TI Vocal Function Exercises for Presbylaryngis: A Multidimensional
   Assessment of Treatment Outcomes
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE dysphonia; presbylaryngis; vocal function exercise; voice analysis
ID AGE-RELATED-CHANGES; VOICE PRODUCTION; DISORDERS; QUALITY; FOLD
AB Objectives: Presbylaryngis, or aging of the larynx, can adversely affect vocal function and quality of life in the elderly. This preliminary investigation examined the effects of vocal function exercises, a physiologic voice therapy approach, as a primary treatment for presbylaryngis.
   Methods: Nine consecutive elderly patients with presbylaryngis (2 female, 7 male) underwent a 6-week course of voice therapy employing vocal function exercises. Pretherapy-versus-posttherapy comparisons were made of self-ratings of voice handicap and phonatory effort level, as well as auditory-perceptual voice assessments, acoustic analyses, and visual-perceptual evaluations of laryngeal images.
   Results: After treatment, patients reported significant reductions on Voice Handicap Index scores, phonatory effort levels, and voice disorder severity. Blinded listeners rated the posttreatment voices as significantly less breathy and strained. However, comparison of pretreatment and posttreatment maximum phonation times, acoustic measures, and laryngeal images did not reveal significant changes.
   Conclusions: These preliminary data suggest that vocal function exercises produce significant functional and perceptual improvements in voice, and deserve further attention as a treatment for elderly patients with presbylaryngis.
C1 [Sauder, Cara; Tanner, Kristine; Houtz, Daniel R.] Univ Utah, Voice Disorders Ctr, Univ Hosp & Clin, Salt Lake City, UT USA.
   [Roy, Nelson] Univ Utah, Dept Commun Sci & Disorders, Salt Lake City, UT USA.
   [Smith, Marshall E.] Univ Utah, Div Otolaryngol Head & Neck Surg, Salt Lake City, UT USA.
RP Sauder, C (reprint author), Univ New Mexico Hosp, Dept Speech Language Pathol, 2211 Lomas Blvd NE, Albuquerque, NM 87106 USA.
FU College of Health, University of Utah
FX From the University of Utah Voice Disorders Center, University Hospitals
   and Clinics (Saucier, Tanner, Houtz), and the Department of
   Communication Sciences and Disorders (Roy) and the Division of
   Otolaryngology Head and Neck Surgery (Smith), University of Utah, Salt
   Lake City, Utah. This work was supported by a faculty creative grant
   from the College of Health, University of Utah.
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NR 23
TC 11
Z9 11
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD JUL
PY 2010
VL 119
IS 7
BP 460
EP 467
PG 8
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 627WP
UT WOS:000280075000006
PM 20734967
ER

PT J
AU Wycherly, BJ
   Manes, RP
   Mikula, SK
AF Wycherly, Benjamin J.
   Manes, R. Peter
   Mikula, Suzette K.
TI Initial Clinical Experience With Balloon Dilation in Revision Frontal
   Sinus Surgery
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT 54th Annual Fall Meeting of the American-Rhinologic-Society
CY SEP 20, 2008
CL Chicago, IL
SP Amer Rhinol Soc
DE balloon dilation; computed tomography; endoscopic sinus surgery; frontal
   sinus; revision surgery; sinusitis
ID SAFETY; FEASIBILITY; OSTIA
AB Objectives: The purpose of this study was to determine whether balloon dilation is effective in revision frontal sinus surgery.
   Methods: We retrospectively reviewed all patients who had previously undergone endoscopic frontal sinus surgery and had persistent sinusitis. All patients then underwent balloon dilation of the frontal ostium. Outcome measurements included endoscopic patency of the frontal ostium, Lund-Mackay scores, culture-positive postoperative infections, and subjective persistence of symptoms.
   Results: Twenty-four frontal ostia and recesses were dilated in 13 patients. The mean follow-up was 13 months (range, 7 to 19 months). During follow-up, 21 of 24 ostia (86%) remained patent and 3 required additional procedures. Postoperative computed tomography scans were performed an average of 12 months after dilation (range, 6 to 18 months) in 9 patients (17 sinuses). The average Lund-Mackay score was 1.35 before dilation and 0.87 at follow-up (p = 0.0076), with 41% of sinuses (7 of 17) displaying radiographic improvement. The average number of postoperative infections was 2.07 (range, 0 to 7). Frontal headaches persisted in 38% of patients (5 of 13) at follow-up.
   Conclusions: Balloon dilation of the frontal Ostia has a posttreatment patency rate comparable to those of other endoscopic revision techniques. Although it may not fully address the frontal sinus disease of all patients, it is a less invasive technique that may be helpful for some patients.
C1 [Wycherly, Benjamin J.; Manes, R. Peter; Mikula, Suzette K.] Georgetown Univ, Dept Otolaryngol Head & Neck Surg, Washington, DC USA.
RP Mikula, SK (reprint author), Georgetown Univ Hosp, Dept Otolaryngol, Gorman 1,3800 S Reservoir Rd NW, Washington, DC 20007 USA.
CR Bhattacharyya T, 1997, ARCH OTOLARYNGOL, V123, P1189
   Bolger WE, 2006, AM J RHINOL, V20, P290, DOI 10.2500/ajr.2006.20.2868
   Bolger WE, 2007, OTOLARYNG HEAD NECK, V137, P10, DOI 10.1016/j.otohns.2007.02.006
   Brown CL, 2006, ANN OTO RHINOL LARYN, V115, P293
   Chiu AG, 2004, OTOLARYNG HEAD NECK, V130, P312, DOI 10.1016/j.otohns.2003.11.005
   DelGaudio John M, 2005, Am J Rhinol, V19, P167
   Lund Valerie J., 1993, Rhinology (Utrecht), V31, P183
   Luong A, 2008, AM J RHINOL, V22, P621, DOI 10.2500/ajr.2008.22.3240
   Orlandi RR, 2001, OTOLARYNG CLIN N AM, V34, P77, DOI 10.1016/S0030-6665(05)70296-6
NR 9
TC 4
Z9 5
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD JUL
PY 2010
VL 119
IS 7
BP 468
EP 471
PG 4
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 627WP
UT WOS:000280075000007
PM 20734968
ER

PT J
AU Montgomery, J
   Syed, MI
   Rana, I
   Singh, J
   Clark, LJ
AF Montgomery, Jennifer
   Syed, Mohammed Iqbal
   Rana, Indu
   Singh, Jatinder
   Clark, Louise J.
TI Hemoglobin Monitoring in Head and Neck Cancer Patients Undergoing
   Radiotherapy
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE hemoglobin; radiotherapy
ID SQUAMOUS-CELL CARCINOMA; PROGNOSTIC VALUE; ANEMIA
AB Objectives: Anemia is a well-recognized factor for local recurrence and decreased survival in cancer patients undergoing radiotherapy. Additionally, lower hemoglobin (Hb) levels have a negative impact on radiotherapy efficacy and response rates. The objective of this audit was to investigate how frequently Hb levels were observed in head and neck cancer patients receiving radiotherapy within a multidisciplinary team setting.
   Methods: We performed a retrospective first-cycle audit in a university hospital in Glasgow that is a tertiary referral center for head and neck cancer. Included were 78 patients with head and neck cancer who were undergoing radiotherapy. Online laboratory services and clinical case sheets were checked for each patient to monitor the frequency of observation of Hb levels before, during, and after radiotherapy.
   Results: Of these 78 patients, only 49 had their Hb level checked before radiotherapy treatment, only 9 during radiotherapy, and only 27 after completion of radiotherapy treatment (p < 0.0001). Of the 49 patients with preradiotherapy Hb levels available, 24% were found to be anemic; none of these patients had their Hb monitored during radiotherapy, and only 4 had Hb levels recorded after completion of treatment.
   Conclusions: This audit has highlighted that despite evidence emphasizing that anemia in cancer is an independent prognostic factor for recurrence, there is no formal protocol for Hb monitoring in head and neck cancer patients undergoing radiotherapy. The audit has also demonstrated that Hb monitoring is infrequently performed and that subsequent observation of the Hb level is suboptimal.
C1 [Montgomery, Jennifer; Syed, Mohammed Iqbal; Rana, Indu; Clark, Louise J.] So Gen Hosp, Greater Glasgow & Clyde NHS Trust, Dept Otolaryngol, Glasgow G51 4TF, Lanark, Scotland.
   [Singh, Jatinder] Primary Biostat Solut, Victoria, BC, Canada.
RP Syed, MI (reprint author), So Gen Hosp, Greater Glasgow & Clyde NHS Trust, Dept Otolaryngol, Glasgow G51 4TF, Lanark, Scotland.
CR Becker A, 2000, INT J RADIAT ONCOL, V46, P459, DOI 10.1016/S0360-3016(99)00384-3
   Bokemeyer C, 2007, EUR J CANCER, V43, P258, DOI 10.1016/j.ejca.2006.10.014
   Daly T, 2003, RADIOTHER ONCOL, V68, P113, DOI 10.1016/S0167-8140(03)00198-1
   Ludwig H, 2004, EUR J CANCER, V40, P2293, DOI 10.1016/j.ejca.2004.06.019
   Macdonald G, 2004, CLIN ONCOL-UK, V16, P63, DOI 10.1016/j.clon.2003.09.009
   Semenza GL, 2000, BIOCHEM PHARMACOL, V59, P47, DOI 10.1016/S0006-2952(99)00292-0
   Skladowski K, 1999, INT J RADIAT ONCOL, V43, P101, DOI 10.1016/S0360-3016(98)00375-7
   Tarnawski R, 1997, INT J RADIAT ONCOL, V38, P1007, DOI 10.1016/S0360-3016(97)00308-8
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   Varlotto J, 2005, INT J RADIAT ONCOL, V63, P25, DOI 10.1016/j.ijrobp.2005.04.049
   Warde P, 1998, INT J RADIAT ONCOL, V41, P347, DOI 10.1016/S0360-3016(98)00062-5
NR 11
TC 0
Z9 0
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD JUL
PY 2010
VL 119
IS 7
BP 472
EP 475
PG 4
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 627WP
UT WOS:000280075000008
PM 20734969
ER

PT J
AU Powitzky, R
   Vasan, N
   Krempl, G
   Medina, J
AF Powitzky, Rosser
   Vasan, Nilesh
   Krempl, Greg
   Medina, Jesus
TI Carotid Blowout in Patients With Head and Neck Cancer
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT Annual Meeting of the American-Head-and-Neck-Society
CY MAY 28-30, 2009
CL Phoenix, AZ
SP Amer Head & Neck Soc
DE carotid artery; head and neck neoplasm
ID ENDOVASCULAR MANAGEMENT; SUPPORTIVE CARE; ARTERY RUPTURE;
   RECONSTRUCTION; HEMORRHAGE; PUNCTURE; STENT
AB Objectives: The objective was to review the clinicopathologic features of carotid blowout syndrome (CBS) in patients with head and neck cancer (HNC) and present a management algorithm.
   Methods: We reviewed all HNC patients with a diagnosis of CBS seen at our tertiary cancer hospital from 1994 to 2009 and performed a retrospective review of all English-language studies documenting CBS cases within the past 15 years.
   Results: Eight patients with HNC developed CBS at our institution, and another 132 HNC patients were presented in 21 studies. Patients with CBS typically have a history of radiotherapy (89%), nodal metastasis (69%), and neck dissection (63%). This disease usually occurs proximal to the carotid bifurcation and is commonly associated with soft tissue necrosis in the neck (55%) and mucocutaneous fistulas (40%). Half of CBS patients present with sentinel bleeding, but 60% of patients will develop a life-threatening hemorrhage requiring emergent intervention. Over 90% of patients with CBS were treated with endovascular therapy, and surgical ligation was rarely indicated. The morbidity and mortality rates of patients with CBS are significant; only 23% have survived without evidence of disease.
   Conclusions: Carotid blowout syndrome is uncommon and can be rapidly fatal without prompt diagnosis and intervention. Although endovascular treatment within the carotid system can have a significant risk of mortality and neurologic morbidity, it has become the treatment of choice for CBS.
C1 [Powitzky, Rosser; Vasan, Nilesh; Krempl, Greg; Medina, Jesus] Univ Oklahoma, Dept Otolaryngol, Hlth Sci Ctr, Oklahoma City, OK 73126 USA.
RP Vasan, N (reprint author), Univ Oklahoma, Dept Otolaryngol, Hlth Sci Ctr, POB 26901 WP 1290, Oklahoma City, OK 73126 USA.
CR Bates MC, 2003, J ENDOVASC THER, V10, P54, DOI 10.1583/1545-1550(2003)010<0054:EMOICR>2.0.CO;2
   Broomfield SJ, 2006, J LARYNGOL OTOL, V120, P694, DOI 10.1017/S0022215106001332
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   Cohen James, 2004, Curr Opin Otolaryngol Head Neck Surg, V12, P110, DOI 10.1097/00020840-200404000-00010
   Desuter G, 2005, PALLIATIVE MED, V19, P427, DOI 10.1191/0269216305pm1032oa
   Hertz Jeffrey A, 2004, Vasc Endovascular Surg, V38, P477, DOI 10.1177/153857440403800515
   Kim HS, 2006, BRIT J RADIOL, V79, P226, DOI 10.1259/bjr/66917189
   Koutsimpelas D, 2008, J PALLIAT MED, V11, P784, DOI 10.1089/jpm.2008.9901
   Lesley WS, 2003, AM J NEURORADIOL, V24, P975
   Luo CB, 2006, EUR ARCH OTO-RHINO-L, V263, P644, DOI 10.1007/s00405-006-0028-8
   Luo Chao-Bao, 2003, J Chin Med Assoc, V66, P140
   Macdonald S, 2000, J VASC INTERV RADIOL, V11, P1184, DOI 10.1016/S1051-0443(07)61361-X
   Morrissey DD, 1997, ARCH OTOLARYNGOL, V123, P15
   Pyun HW, 2007, AM J NEURORADIOL, V28, P1594, DOI 10.3174/ajnr.A0589
   Roh JL, 2008, ORAL ONCOL, V44, P844, DOI 10.1016/j.oraloncology.2007.11.003
   Roth TC, 1998, AM J NEURORADIOL, V19, P912
   Simental A, 2003, AM J OTOLARYNG, V24, P417, DOI 10.1053/S0196-0709(03)00088-7
   Sorial E, 2007, J VASC SURG, V46, P792, DOI 10.1016/j.jvs.2007.05.052
   Upile T, 2005, EUR ARCH OTO-RHINO-L, V262, P555, DOI 10.1007/s00405-004-0775-3
   Wang H, 2005, NEUROCRIT CARE, V2, P176, DOI 10.1385/Neurocrit.Care2005;2:176-178
   Warren FM, 2002, LARYNGOSCOPE, V112, P428, DOI 10.1097/00005537-200203000-00004
NR 23
TC 19
Z9 21
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD JUL
PY 2010
VL 119
IS 7
BP 476
EP 484
PG 9
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 627WP
UT WOS:000280075000009
PM 20734970
ER

PT J
AU Johnston, DR
   Gaslin, M
   Boon, M
   Pribitkin, E
   Rosen, D
AF Johnston, Douglas R.
   Gaslin, Michael
   Boon, Maurits
   Pribitkin, Edmund
   Rosen, David
TI Postoperative Complications of Powered Intracapsular Tonsillectomy and
   Monopolar Electrocautery Tonsillectomy in Teens Versus Adults
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT 36th Annual Meeting of the
   Society-for-Ear-Nose-and-Throat-Advances-in-Children
CY DEC 04-07, 2008
CL Boston, MA
SP Soc Ear, Nose & Throat Advances Children
DE adolescent; electrocautery; hemorrhage; intracapsular tonsillectomy;
   tonsillectomy
ID MICRODEBRIDER; HEMORRHAGE; CHILDREN
AB Objectives: This study was performed to determine whether teens have different rates of posttonsillectomy hemorrhage, admission for dehydration, or recurrent tonsillitis compared to adults. Specifically, these parameters were compared within two groups: patients who underwent powered intracapsular tonsillectomy (PIT) and those who underwent monopolar electrocautery tonsillectomy (MET).
   Methods: In a retrospective review of 579 patients at least 12 years of age from January 2000 to July 2006 in a tertiary referral center, outcome measures of reoperation for hemorrhage, readmission or emergency room visit for dehydration, and postoperative tonsillitis were compared for 200 patients 12 to 19 years of age and 379 patients more than 19 years of age. These outcome measures in teens were compared to those in adults who had tonsillectomy by the same technique (101 teens who underwent PIT compared to 117 adults who underwent PIT, and 99 teens who underwent MET compared to 262 adults who underwent MET). Outcome measures were also compared within the PIT and MET groups based on the indication for surgery (chronic tonsillitis, tonsillar hypertrophy, or both).
   Results: In comparing teens to adults who underwent the same technique (PIT versus PIT, or MET versus MET), no statistically significant differences existed in the incidence of hemorrhage, dehydration, or postoperative tonsillitis. Greater hemorrhage rates for adults who underwent MET compared to teens, however, almost met statistical significance (p = 0.053). Analyzing complication rates by indication within the PIT and MET groups exclusively revealed higher rates of hemorrhage in adults who underwent the MET technique for the indication of chronic tonsillitis. Within the PIT comparison, no significant differences were found on the basis of indication for surgery.
   Conclusions: Teenage patients who undergo tonsillectomy should be considered unique as far as complication rates are concerned. Comparison of technique-specific complication rates between adults and teens showed no significant differences in either the PIT or MET groups, although adults who underwent MET had greater hemorrhage rates that almost met significance (p = 0.053). Adults who were undergoing tonsillectomy for chronic tonsillitis were more likely than teens to encounter postoperative hemorrhage if they underwent the MET technique.
C1 [Johnston, Douglas R.; Gaslin, Michael; Boon, Maurits; Pribitkin, Edmund; Rosen, David] Thomas Jefferson Univ Hosp, Dept Otolaryngol Head & Neck Surg, Philadelphia, PA 19107 USA.
RP Rosen, D (reprint author), Thomas Jefferson Univ, Dept Otolaryngol Head & Neck Surg, 925 Chestnut St 6th Floor, Philadelphia, PA 19107 USA.
CR Blakley BW, 2009, OTOLARYNG HEAD NECK, V140, P288, DOI 10.1016/j.otohns.2008.12.005
   Derkay CS, 2006, OTOLARYNG HEAD NECK, V134, P114, DOI 10.1016/j.otohns.2005.10.039
   Glade RS, 2006, OTOLARYNG HEAD NECK, V134, P852, DOI 10.1016/j.otohns.2005.11.005
   Hoddeson EK, 2009, OTOLARYNG HEAD NECK, V140, P19, DOI 10.1016/j.otohns.2008.09.023
   Koltai PJ, 2002, LARYNGOSCOPE, V112, P17
   Lee KD, 2008, CLIN ANAT, V21, P33, DOI 10.1002/ca.20562
   Lister MT, 2006, ARCH OTOLARYNGOL, V132, P599, DOI 10.1001/archotol.132.6.599
   Myssiorek D, 1996, INT J PEDIATR OTORHI, V37, P35, DOI 10.1016/0165-5876(96)01364-X
   Schmidt R, 2007, OTOLARYNG HEAD NECK, V137, P338, DOI 10.1016/j.otohns.2007.03.045
   Schmidt R, 2007, ARCH OTOLARYNGOL, V133, P925, DOI 10.1001/archotol.133.9.925
   Sobol SE, 2006, ARCH OTOLARYNGOL, V132, P270, DOI 10.1001/archotol.132.3.270
   Solares CA, 2005, INT J PEDIATR OTORHI, V69, P21, DOI 10.1016/j.ijporl.2004.07.006
   Sorin A, 2004, LARYNGOSCOPE, V114, P297, DOI 10.1097/00005537-200402000-00022
   Tomkinson A, 2005, CLIN OTOLARYNGOL, V30, P338, DOI 10.1111/j.1365-2273.2005.01045.x
NR 14
TC 4
Z9 4
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD JUL
PY 2010
VL 119
IS 7
BP 485
EP 489
PG 5
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 627WP
UT WOS:000280075000010
PM 20734971
ER

PT J
AU Inokuchi, G
   Okuno, T
   Hata, Y
   Baba, M
   Sugiyama, D
AF Inokuchi, Go
   Okuno, Taeko
   Hata, Yuko
   Baba, Miyuki
   Sugiyama, Daisuke
TI Congenital Cholesteatoma: Posterior Lesions and the Staging System
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE congenital cholesteatoma; endoscopy; posterior-quadrant cholesteatoma;
   staging
ID MIDDLE-EAR CHOLESTEATOMA; PATHOGENESIS; CHILDREN
AB Objectives: We described the characteristics of congenital cholesteatoma in Japanese patients and assessed whether the staging, system is useful for predicting the rate of residual disease, the need for reexploration, and surgical outcomes.
   Methods: We performed a retrospective chart analysis of 23 consecutive patients with congenital cholesteatoma.
   Results: The proportion of cases with anterior-superior quadrant involvement was significantly lower in the Asian group than in Western patients. The total residual rate was 26%, and there was a positive association between stage and residual rate, ranging from 0% in stage I and II to 44% in stage IV. Canal wall-up tympanomastoidectomy was the most frequent procedure (57%), and 61% had reexploration.
   Conclusions: Congenital cholesteatoma in Asia is less likely to involve the anterior-superior quadrant than in Western patients. The 4-stage system was useful for predicting residual rates, even in patients in whom anterior-superior quadrant involvement was less common. Postoperative hearing was significantly related to the stages. A routine second-look procedure may be unnecessary in the early stages, whereas reexploration would be better performed in advanced stages. Endoscopy might reduce residual disease and the need for reexploration in the near future.
C1 [Inokuchi, Go; Okuno, Taeko; Hata, Yuko; Baba, Miyuki] Mitsui Mem Hosp, Dept Otorhinolaryngol, Tokyo 101, Japan.
   [Sugiyama, Daisuke] Kobe Univ, Grad Sch Med, Dept Evidence Based Lab Med, Kobe, Hyogo 657, Japan.
RP Inokuchi, G (reprint author), Nishi Kobe Med Ctr, Dept Otolaryngol, Nishi Ku, 5-7-1 Kouji Dai, Kobe, Hyogo 6512273, Japan.
CR AIMI K, 1983, LARYNGOSCOPE, V93, P1140
   Ayache S, 2008, OTOL NEUROTOL, V29, P1085, DOI 10.1097/MAO.0b013e318188e8d7
   Good GM, 1999, ANN OTO RHINOL LARYN, V108, P893
   Kashiwamura M, 2005, AM J OTOLARYNG, V26, P372, DOI 10.1016/j.amgoto.2005.02.014
   Kikuchi Masahiro, 2003, Nihon Jibiinkoka Gakkai Kaiho, V106, P797
   Kojima H, 2006, AM J OTOLARYNG, V27, P299, DOI 10.1016/j.amjoto.2005.11.016
   Koltai PJ, 2002, ARCH OTOLARYNGOL, V128, P804
   LEVENSON MJ, 1986, OTOLARYNG HEAD NECK, V94, P560
   MICHAELS L, 1986, J OTOLARYNGOL, V15, P169
   Nelson M, 2002, ARCH OTOLARYNGOL, V128, P810
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   Persaud R, 2007, J LARYNGOL OTOL, V121, P1013
   Potsic WP, 2002, OTOLARYNG HEAD NECK, V126, P409, DOI 10.1067/mhn.2002.123446
   Potsic WP, 2002, ARCH OTOLARYNGOL, V128, P1009
   Tos M, 2000, LARYNGOSCOPE, V110, P1890, DOI 10.1097/00005537-200011000-00023
   Yeo SW, 2001, AM J OTOLARYNG, V22, P184, DOI 10.1053/ajot.2001.23424
NR 16
TC 1
Z9 1
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD JUL
PY 2010
VL 119
IS 7
BP 490
EP 494
PG 5
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 627WP
UT WOS:000280075000011
PM 20734972
ER

PT J
AU Suzuki, M
   Kashio, A
   Sakamoto, T
   Yamasoba, T
AF Suzuki, Mitsuya
   Kashio, Akinori
   Sakamoto, Takashi
   Yamasoba, Tatsuya
TI Effect of Burow's Solution on the Guinea Pig Inner Ear
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT 32nd Annual Midwinter Meeting of the
   Association-for-Research-in-Otolaryngology
CY FEB 14-19, 2009
CL Baltimore, MD
SP Assoc Res Otolaryngol
DE acetic acid; auditory brain stem response; Burow's solution;
   intratympanic injection; ototoxicity; surface preparation
ID ROUND WINDOW MEMBRANE; SUPPURATIVE OTITIS-MEDIA; NA+,K+-ATPASE;
   FIBROBLASTS; EFFICACY; COCHLEAR; CHILDREN; DROPS
AB Objectives: We examined the changes in the inner car hair cells following intratympanic injection of Burow's solution.
   Methods: Thirty-one albino guinea pigs with a normal Preyer's reflex were used. Burow's solution was applied and allowed to remain on the round window membrane for 30 minutes (30-minute group), 1 hour (1-hour group), or 2 hours (2-hour group). Seven days later, the left temporal bone was removed. Auditory brain stem responses were recorded at 4, 8, and 20 kHz before application of Burow's solution and again immediately before decapitation. The cochlea and utricle were dissected, stained with rhodamine-phalloidin, and examined under a fluorescence microscope.
   Results: The postoperative auditory brain stem response thresholds at 20 kHz in the I-hour group and those at 8 and 20 kHz in the 2-hour group were increased significantly compared to the baseline thresholds. Surface preparations of the organ of Corti revealed no hair cell loss in the 30-minute group, loss of outer hair cells in the lower half of the basal turn in half of the animals in the 1-hour group, and loss of outer hair cells in the basal turn in almost all animals in the 2-hour group. In the 2-hour group, the microthin sections of the round window membrane showed degeneration of the outer epithelium.
   Conclusions: The retention of Burow's solution on the round window membrane for 2 hours induces degeneration of the outer epithelium and damage to the cochlear outer hair cells.
C1 [Suzuki, Mitsuya; Kashio, Akinori; Sakamoto, Takashi; Yamasoba, Tatsuya] Univ Tokyo, Dept Otolaryngol, Tokyo 113, Japan.
RP Suzuki, M (reprint author), Toho Univ, Sakura Med Ctr, Dept Otolaryngol, 564-1 Shimo Shizu, Sakura, Chiba 2850841, Japan.
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   Goycoolea MV, 2001, ACTA OTO-LARYNGOL, V121, P437, DOI 10.1080/000164801300366552
   Hamada M, 1999, ACTA OTO-LARYNGOL, V119, P778
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   Penha Rui, 2005, Int Tinnitus J, V11, P31
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NR 21
TC 4
Z9 4
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD JUL
PY 2010
VL 119
IS 7
BP 495
EP 500
PG 6
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 627WP
UT WOS:000280075000012
PM 20734973
ER

PT J
AU Kimura, M
   Nito, T
   Imagawa, H
   Sakakibara, KI
   Chan, RW
   Tayama, N
AF Kimura, Miwako
   Nito, Takaharu
   Imagawa, Hiroshi
   Sakakibara, Ken-Ichi
   Chan, Roger W.
   Tayama, Niro
TI Collagen Injection for Correcting Vocal Fold Asymmetry: High-Speed
   Imaging
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE diplophonia; fundamental frequency; high-speed imaging; medialization;
   vocal fold asymmetry
ID MEDIALIZATION LARYNGOPLASTY; CLINICAL-EXPERIENCE; VIBRATION;
   AUGMENTATION; PARALYSIS; RECORDINGS; KYMOGRAPHY; DYNAMICS; MODEL
AB Objectives: We hypothesized that high-speed digital imaging with videokymographic and laryngotopographic analysis would provide a quantitative method to evaluate the effect of collagen injection for the correction of asymmetric and irregular vocal fold vibration in unilateral vocal fold paralysis.
   Methods: Videokymographic and laryngotopographic analysis was performed for high-speed digital recordings of vocal fold vibration for visualizing the glottal vibratory patterns, and for quantifying the frequency of vibration of each vocal fold, respectively, including comparisons between the paralyzed and normal vocal folds before and after surgery. This included prospective observations of 11 subjects with unilateral vocal fold paralysis (4 male, 7 female; mean +/- SD age, 67.1 +/- 12.0 years) using high-speed digital image analysis before and after collagen injection.
   Results: Analysis of the laryngotopographs revealed 2 distinct frequencies of vibration for the paralyzed and contralateral vocal folds for 8 of the 11 subjects before surgery. After collagen injection, the vibration frequencies became identical, despite asymmetric vibration amplitudes. Asymmetric vibration amplitudes were also observed in the other 3 subjects before surgery, but the amplitudes became symmetric after collagen injection, despite a persistent phase shift.
   Conclusions: Asymmetric vibration in vocal fold paralysis was exemplified by differences in vibration frequency and amplitude between the vocal folds. The present study showed that after collagen injection, these aspects of vibratory patterns improved toward symmetry. This surgical procedure could improve the functional symmetry of the larynx for phonation.
C1 [Kimura, Miwako; Chan, Roger W.] Univ Texas SW Med Ctr Dallas, Dept Otolaryngol Head & Neck Surg, Dallas, TX 75390 USA.
   [Chan, Roger W.] Univ Texas SW Med Ctr Dallas, Dept Biomed Engn, Dallas, TX 75390 USA.
   [Nito, Takaharu; Imagawa, Hiroshi] Univ Tokyo, Dept Otorhinolaryngol & Head & Neck Surg, Tokyo, Japan.
   [Sakakibara, Ken-Ichi] Hlth Sci Univ Hokkaido, Dept Commun Disorders, Sapporo, Hokkaido, Japan.
RP Kimura, M (reprint author), Univ Texas SW Med Ctr Dallas, Dept Otolaryngol Head & Neck Surg, 5323 Harry Hines Blvd, Dallas, TX 75390 USA.
FU Departments of Otolaryngology Head; Neck Surgery (Kimura, Chan);
   Biomedical Engineering (Chan); University of Texas Southwestern Medical
   Center, Dallas, Texas; Department of Otolaryngology, International
   Medical Center of Japan (Kimura, Tayama)
FX From the Departments of Otolaryngology Head and Neck Surgery (Kimura,
   Chan) and Biomedical Engineering (Chan), University of Texas
   Southwestern Medical Center, Dallas, Texas, and the Department of
   Otolaryngology, International Medical Center of Japan (Kimura, Tayama).
   and the Department of Otorhinolaryngology and Head and Neck Surgery.
   University of Tokyo (Nito, Imagawa. Tayama), Tokyo. and the Department
   of Communication Disorders, Health Sciences University of Hokkaido.
   Sapporo (Sakakibara), Japan. This study was supported by a Grant-in-Aid
   (No. 19791193) for Young Scientists (B) from the Japanese Ministry of
   Education. Culture, Sports, Science and Technology, by the Sankyo
   Foundation of Life Science, by a grant-in-aid (KAKENHI) from MEXT, Japan
   (20500161), and by the National Institutes of Health (NIDCD grant R01
   DC006101).
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NR 31
TC 11
Z9 11
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD JUN
PY 2010
VL 119
IS 6
BP 359
EP 368
PG 10
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 609VR
UT WOS:000278686500001
PM 20583733
ER

PT J
AU McCulloch, TM
   Hoffman, MR
   Ciucci, MR
AF McCulloch, Timothy M.
   Hoffman, Matthew R.
   Ciucci, Michelle R.
TI High-Resolution Manometry of Pharyngeal Swallow Pressure Events
   Associated With Head Turn and Chin Tuck
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE dysphagia; high-resolution manometry; pharyngeal pressure; swallowing
   maneuver
ID SUPRAGLOTTIC SWALLOW; EFFORTFUL SWALLOW; SIMULTANEOUS VIDEORADIOGRAPHY;
   VIDEOMANOMETRIC ANALYSIS; DYSFUNCTION; VOLUNTEERS; MANEUVERS; ROTATION
AB Objectives: We quantified the effect of swallowing maneuvers on pharyngeal pressure events using high-resolution manometry.
   Methods: Seven subjects swallowed multiple 5-mL water boluses in 3 different postural conditions: neutral, head turn. and chin tuck. Pressure and timing events were recorded with a 36-sensor high-resolution manometry catheter. We analyzed the regions of the velopharynx and the base of the tongue for maximum pressure. rate of pressure increase, pressure gradient, and duration of pressure above baseline. In the region of the upper esophageal sphincter (UES), we analyzed the duration of pressure declination, minimum pressure during UES opening, and maximum pressures before and alter LIES opening.
   Results: The maneuvers did not have a significant effect on maximum pressure, rate of pressure increase, or pressure gradients in the velopharyngeal or tongue base regions. The duration of pressure above baseline was significantly longer in the velopharynx for head turn. The preswallow maximum LIES pressure was significantly greater for neutral swallows than for head turn, and the postswallow maximum pressure was significantly lower for chin tuck. Both mane users appeared to prolong LIES pressure declination duration, but neither prolongation reached significance.
   Conclusions: High-resolution manometry allows for optimal spatial and temporal resolution during recording of pressure events along the length of the pharynx, and revealed previously undetected task-dependent pressure and timing differences during chin tuck and head turn in healthy adults. These maneuvers appear to influence the UES to a greater degree than the velopharynx or the tongue base. Further studies designed to quantify the effect of other maneuvers and bolus consistencies on the generation of pharyngeal pressure events both in normal and in disordered subjects may lead to hypothesis-driven, optimal, individualized swallowing therapies.
C1 [McCulloch, Timothy M.; Hoffman, Matthew R.; Ciucci, Michelle R.] Univ Wisconsin, Sch Med, Dept Surg, Div Otolaryngol Head & Neck Surg, Madison, WI 53706 USA.
RP McCulloch, TM (reprint author), Box 7375 Clinical Sci Ctr,H4,600 Highland Ave, Madison, WI 53792 USA.
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NR 21
TC 27
Z9 30
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD JUN
PY 2010
VL 119
IS 6
BP 369
EP 376
PG 8
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 609VR
UT WOS:000278686500002
PM 20583734
ER

PT J
AU Stoor, P
   Pulkkinen, J
   Grenman, R
AF Stoor, Patricia
   Pulkkinen, Jaakko
   Grenman, Reidar
TI Bioactive Glass S53P4 in the Filling of Cavities in the Mastoid Cell
   Area in Surgery for Chronic Otitis Media
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE bioactive glass; otitis media; surgical treatment
ID CANAL WALL; SEPTAL PERFORATIONS; OBLITERATION; RECONSTRUCTION; BONE;
   HYDROXYLAPATITE; HYDROXYAPATITE; MICROORGANISMS; EXPERIENCE; GRANULES
AB Objectives: Chronic infection of the middle ear and cholesteatoma can be treated surgically by exenteration of the mastoid air cells behind the ear. After a procedure with the canal wall-down technique, a cavity remains that is sometimes difficult to clean, collects crust, and becomes repeatedly infected. Such problematic mastoid cavities can he eliminated by filling the created cavity surgically after thorough removal of mucous membranes and cleaning of the bone.
   Methods: We treated 7 patients with cavities after canal wall-down surgery for the treatment of chronic suppurative otitis media or cholesteatoma by filling the difficult-to-clean cavity in the mastoid cell area with granules of bioactive glass (BAG) S53P4 to avoid further retraction formation, The area with BAG was carefully closed with a musculoperiosteal flap.
   Results: After the canal wall down tympanomastoidectomy, the mastoid cavities were successfully filled in all 7 patients. No biomaterial-associated infection was seen, and no disadvantages for the patients due to the BAG were observed. The cavity in the mastoid cell area decreased in size in all patients treated.
   Conclusions: This BAG seems to be a promising material for filling mastoid cavities after canal wall-down tympanomastoidectomy.
C1 [Pulkkinen, Jaakko; Grenman, Reidar] Turku Univ Hosp, Dept Otorhinolaryngol Head & Neck Surg, Turku 20521, Finland.
   [Stoor, Patricia] Helsinki Univ Cent Hosp, Dept Maxillofacial Surg, Helsinki, Finland.
RP Grenman, R (reprint author), Turku Univ Hosp, Dept Otorhinolaryngol Head & Neck Surg, POB 52, Turku 20521, Finland.
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NR 35
TC 8
Z9 8
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD JUN
PY 2010
VL 119
IS 6
BP 377
EP 382
PG 6
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 609VR
UT WOS:000278686500003
PM 20583735
ER

PT J
AU Kelchner, LN
   Weinrich, B
   Brehm, SB
   Tabangin, ME
   de Alarcon, A
AF Kelchner, Lisa N.
   Weinrich, Barbara
   Brehm, Susan Baker
   Tabangin, Meredith E.
   de Alarcon, Alessandro
TI Characterization of Supraglottic Phonation in Children After Airway
   Reconstruction
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE airway reconstruction; pediatric voice; supraglottic phonation; voice
   evaluation
ID PEDIATRIC LARYNGOTRACHEAL RECONSTRUCTION; QUALITY
AB Objectives: We examined select acoustic (signal type), aerodynamic. and perceptual measures and associated surgical data in a cohort of children who were endoscopically identified as using supraglottic phonation after undergoing airway reconstruction.
   Methods: Twenty-one children (4 to 18 years of age) who were seen in the Cincinnati Children's Hospital Medical Center for Pediatric Voice Disorders and identified as using supraglottic phonation were included in this study. According to standard protocol. each of these children underwent acoustic, aerodynamic, and perceptual analyses and laryngeal imaging. Their medical records were reviewed for surgical history.
   Results: Four primary supraglottic compression patterns and 3 distinct sound sources for voice were identified. Signal type classification revealed that 20 of 21 voice signals were either type II or type III. Signal type was moderately associated with compression pattern (p = 0.01). No statistically significant findings were found in testing the Consensus Auditory Perceptual Evaluation of Voice (CAPE-V) Overall Severity score against compression patterns and vibration source. The mean Strain scores for participants who used a combined source of vibration were significantly higher than for those who used their ventricular folds.
   Conclusions: The compensatory compression patterns and alternate sources of vibration used by these children resulted in moderate to severe dysphonias. How children compensate after undergoing airway reconstruction has important implications for behavioral and surgical interventions aimed at improving voice quality. Not all aspects of traditional voice evaluation are suitable for this population.
C1 [Kelchner, Lisa N.; Weinrich, Barbara; Brehm, Susan Baker; Tabangin, Meredith E.; de Alarcon, Alessandro] Cincinnati Childrens Hosp, Med Ctr, Ctr Pediat Voice Disorders, Cincinnati, OH USA.
RP Kelchner, LN (reprint author), Univ Cincinnati, POB 670375, Cincinnati, OH 45267 USA.
CR [Anonymous], 2003, CONS AUD PERC EV VOI
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NR 14
TC 9
Z9 9
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD JUN
PY 2010
VL 119
IS 6
BP 383
EP 390
PG 8
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 609VR
UT WOS:000278686500004
PM 20583736
ER

PT J
AU Francis, DO
   Weymuller, EA
   Parvathaneni, U
   Merati, AL
   Yueh, B
AF Francis, David O.
   Weymuller, Ernest A., Jr.
   Parvathaneni, Upendra
   Merati, Albert L.
   Yueh, Bevan
TI Dysphagia, Stricture, and Pneumonia in Head and Neck Cancer Patients:
   Does Treatment Modality Matter?
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE dysphagia; esophageal stricture; head and neck cancer; pneumonia;
   treatment toxicity
ID QUALITY-OF-LIFE; CONCURRENT CHEMORADIATION; COMORBIDITY INDEX;
   ASPIRATION; RADIOTHERAPY; RADIATION; CHEMOTHERAPY; CARCINOMA
AB Objectives: Dysphagia-related sequelae are common after head and neck cancer treatment. Our aims were 1) to document overall and site-specific dysphagia, stricture, and pneumonia rates in a Medicare population, 2) to calculate treatment-specific rates and adjusted odds of developing these complications, and 3) to track changes in rates between 1992 and 1999.
   Methods: Head and neck cancer patients between 1992 and 1999 were identified in combined Surveillance Epidemiology and End Results (SEER) registry and Medicare databases. Multivariate analyses determined odds of dysphagia, stricture, and pneumonia based on modality.
   Results: Of 8,002 patients, 40% of experienced dysphagia, 7% stricture, and 10% pneumonia within 3 years of treatment. In adjusted analyses, patients treated with chemoradiation had more than 2.5-times-greater odds of dysphagia than did those treated with surgery alone. Combined therapy was associated with increased odds of stricture (p < 0.05). The odds of pneumonia were increased in patients treated with radiation with or without chemotherapy. Temporally, the dysphagia rates increased 10% during this period (p < 0.05).
   Conclusions: Sequelae of head and neck cancer treatment are common and differ by treatment regimen. Those treated with chemoradiation had higher odds of experiencing dysphagia and pneumonia, whereas patients treated with any combined therapy more commonly experienced stricture. These sequelae represent major sources of morbidity and mortality in this population.
C1 [Francis, David O.; Weymuller, Ernest A., Jr.; Merati, Albert L.] Univ Washington, Dept Otolaryngol Head & Neck Surg, Seattle, WA 98195 USA.
   [Parvathaneni, Upendra] Univ Washington, Dept Radiat Oncol, Seattle, WA 98195 USA.
   [Yueh, Bevan] Univ Minnesota, Dept Otolaryngol Head & Neck Surg, Minneapolis, MN USA.
RP Francis, DO (reprint author), 1959 NE Pacific St,Box 315616, Seattle, WA 98195 USA.
FU American Academy of Otolaryngology Head and Neck Surgery Foundation
   Health Service Research CORE
FX From the Departments of Otolaryngology Head and Neck Surgery (Francis,
   Weymuller, Merati) and Radiation Oncology (Parvathaneni), University of
   Washington, Seattle, Washington, and the Department of Otolaryngology
   Head and Neck Surgery, University of Minnesota, Minneapolis, Minnesota
   (Yueh). Supported by an American Academy of Otolaryngology Head and Neck
   Surgery Foundation Health Service Research CORE Grant.
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NR 22
TC 30
Z9 31
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD JUN
PY 2010
VL 119
IS 6
BP 391
EP 397
PG 7
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 609VR
UT WOS:000278686500005
PM 20583737
ER

PT J
AU O'Kane, L
   Groher, ME
   Silva, K
   Osborn, L
AF O'Kane, Lisa
   Groher, Michael E.
   Silva, Kathleen
   Osborn, Lori
TI Normal Muscular Activity During Swallowing as Measured by Surface
   Electromyography
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE dysphagia; surface electromyography; swallowing rehabilitation
ID 440 ADULTS; QUANTITATIVE DATA; DYSPHAGIA; BIOFEEDBACK; VISCOSITY;
   VOLUME; FORCE
AB Objectives: Speech-language pathologists use surface electromyography biofeedback as a tool to facilitate swallowing treatment, particularly to improve swallowing strength and coordination. The present study sought to establish normative data of swallowing muscular activity as measured by surface electrodes in order to compare the performance of patients with dysphagia to normal swallow performance.
   Methods: Thirty normal young (18 to 25 years of age) and elderly (60 or more years of age) subjects swallowed 3 bolus volumes (5,10, and 20 mL) in 2 conditions: swallow-to-command and swallow-when-ready. Swallow muscular activity was measured in microvolts with a portable biofeedback unit.
   Results: There were significant differences between the 2 swallowing conditions in both age groups. Neither age nor bolus volume had a significant effect on the findings.
   Conclusions: In using surface electromyography biofeedback as an adjunct to swallowing rehabilitation, it may be more beneficial to use swallow-to-command techniques if one is interested in measuring maximum effort, regardless of patient age or volume selected.
C1 [O'Kane, Lisa; Groher, Michael E.; Osborn, Lori] Univ Redlands, Dept Communicat Disorders, Redlands, CA 92373 USA.
   [Silva, Kathleen] Univ Redlands, Dept Psychol, Redlands, CA 92373 USA.
RP Groher, ME (reprint author), Univ Redlands, Dept Communicat Disorders, 1200 E Colton Ave, Redlands, CA 92373 USA.
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NR 16
TC 1
Z9 1
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD JUN
PY 2010
VL 119
IS 6
BP 398
EP 401
PG 4
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 609VR
UT WOS:000278686500006
PM 20583738
ER

PT J
AU Yates, CW
   Weinberg, M
   Packer, MJ
   Jacob, A
AF Yates, Charles W.
   Weinberg, Mitchell
   Packer, Mark J.
   Jacob, Abraham
TI Fatal Case of Tumor-Associated Hemorrhage in a Large Vestibular
   Schwannoma
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE anticoagulant; hemorrhage; mortality; vestibular schwannoma
ID INTRATUMORAL HEMORRHAGE; ACOUSTIC NEUROMA; POPULATION
AB Vestibular schwannomas are benign neoplasms that arise from Schwann cells of the eighth cranial nerve. Most manifest clinically with tinnitus, unilateral sensorineural hearing loss, and dysequilibrium secondary to compression of the vestibulocochlear nerve; major adverse events such as intratumoral hemorrhage causing acute neurologic deterioration are rare. We report the case of a 69-year-old man with a large vestibular schwannoma who required anticoagulation for several medical comorbidities. The patient began having progressively worsening neurologic symptoms, including facial nerve paralysis and dysequilibrium, which confined him to a wheelchair. After presentation, the patient was admitted to the hospital. Several days after alteration of his anticoagulation therapy in preparation for surgery, he developed intracranial hemorrhage. Attempts were made to stabilize the patient, including posterior fossa craniectomy and evacuation of hematoma; however, the intracranial hemorrhage ultimately resulted in a fatal outcome. During this procedure, a biopsy specimen was obtained, showing benign vestibular schwannoma. The literature for intratumoral hemorrhage into vestibular schwannoma and the pathologic findings in our case are reviewed.
C1 [Yates, Charles W.; Packer, Mark J.; Jacob, Abraham] Ohio State Univ, Dept Otolaryngol Head & Neck Surg, OSU Eye & Ear Inst, Columbus, OH 43212 USA.
   [Weinberg, Mitchell] Ohio State Univ, Dept Pathol, Columbus, OH 43212 USA.
RP Yates, CW (reprint author), Ohio State Univ, Dept Otolaryngol Head & Neck Surg, OSU Eye & Ear Inst, 915 Olentangy River Rd, Columbus, OH 43212 USA.
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NR 11
TC 3
Z9 3
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD JUN
PY 2010
VL 119
IS 6
BP 402
EP 405
PG 4
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 609VR
UT WOS:000278686500007
PM 20583739
ER

PT J
AU Wang, JH
   Lee, BJ
   Jang, YJ
AF Wang, Jong Hwan
   Lee, Bong-Jae
   Jang, Yong Ju
TI Bacterial Coinfection and Antimicrobial Resistance in Patients With
   Paranasal Sinus Fungus Balls
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE antibiotics; bacteria; coinfection; fungus ball; paranasal sinus;
   resistance
ID INTENSIVE-CARE-UNIT; CHRONIC RHINOSINUSITIS; STAPHYLOCOCCUS-AUREUS;
   SURGERY; CULTURES
AB Objectives: The aim of this study was to investigate the incidence of bacterial coinfection and antimicrobial resistance in cases of fungus balls of the paranasal sinuses.
   Methods: Between December 1991 and August 2008, 229 patients underwent encloscopic sinus surgery or the CaldwellLuc procedure for paranasal sinus fungus ball treatment. From 123 of these patients, a total of 124 specimens were obtained for aerobic and anaerobic culture. Antimicrobial susceptibility tests were performed.
   Results: Ninety-one cultures (73.4%) were positive for bacteria, and 33 showed no bacterial growth. A total of 134 bacterial organisms were isolated: 65 gram-positive, 55 gram-negative, and 14 anaerobic. The most frequently isolated organisms were coag,ulase-negative.S.tapkvlococcus (14.9%), Staphylococcus (wrens (12.7%), Enterobacter aerogenes (12.7%), viridans-group streptococci (8.9%), and Pseudomonas aeruginosa (8.2%). Among the gram-positive cocci, 12.2% were resistant to ciprofloxacin, 27.6% to clindamycin, 30% to oxacillin, 35.8% to erythromycin, 35.9% to trimethoprim-sulfamethoxazole, 56.5% to penicillin, 56.8% to gentamicin, and 0% to teicoplanin and vancomycin. Among the gram-negative rods, fewer than 100/c were resistant to imipenem, piperacillin-tazobactam, amikacin, gentamicin, ceftazidime, cefepime, and tobramycin, whereas more than 80% showed resistance to ampici I lin and cefazolin. When we compared the data from the periods 1991 to 2000 and 2(101 to 2008, there were no significant differences in the isolation rates of particular bacterial species and no significant differences in resistance rates except for clindamycin-resistant gram-positive cocci and cefazolin-resistant gram-negative rods.
   Conclusions: Bacterial coinfections were identified in more than two thirds of patients with fungus balls and purulent secretions. This finding suggests that bacterial infection may influence the development and persistence of clinical symptoms in a substantial portion of fungus ball cases.
C1 [Wang, Jong Hwan; Lee, Bong-Jae; Jang, Yong Ju] Univ Ulsan, Coll Med, Asan Med Ctr, Dept Otolaryngol, Seoul 138736, South Korea.
RP Jang, YJ (reprint author), Univ Ulsan, Coll Med, Asan Med Ctr, Dept Otolaryngol, 388-1 Pungnap 2Dong, Seoul 138736, South Korea.
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NR 19
TC 3
Z9 3
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD JUN
PY 2010
VL 119
IS 6
BP 406
EP 411
PG 6
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 609VR
UT WOS:000278686500008
PM 20583740
ER

PT J
AU Li, NYK
   Vodovotz, Y
   Hebda, PA
   Abbott, KV
AF Li, Nicole Y. K.
   Vodovotz, Yoram
   Hebda, Patricia A.
   Abbott, Katherine Verdolini
TI Biosimulation of Inflammation and Healing in Surgically Injured Vocal
   Folds
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE computer simulation; inflammation; systems biology; vocal fold; wound
   healing
ID IDIOPATHIC PULMONARY-FIBROSIS; HEPATOCYTE GROWTH-FACTOR; ENDOGENOUS
   DANGER SIGNAL; HEAT-SHOCK PROTEINS; MATRIX METALLOPROTEINASES; ALVEOLAR
   MACROPHAGES; HYALURONAN FRAGMENTS; SYSTEMS BIOLOGY; GENE-EXPRESSION;
   CANINE MODEL
AB Objectives: The pathogenesis of vocal fold scarring is complex and remains to he deciphered. The current study is part of research endeavors aimed at applying systems biology approaches to address the complex biological processes involved in the pathogenesis of vocal fold scarring and other lesions affecting the larynx.
   Methods: We developed a computational agent-based model (ABM) to quantitatively characterize multiple cellular and molecular interactions involved in inflammation and healing in vocal fold mucosa after surgical trauma. The ABM was calibrated with empirical data on inflammatory mediators (eg, tumor necrosis factor) and extracellular matrix components (eg, hyaluronan) from published studies on surgical vocal fold injury in the rat population.
   Results: The simulation results reproduced and predicted trajectories seen in the empirical data from the animals. Moreover, the ABM studies suggested that hyaluronan fragments might be the clinical surrogate of tissue damage, a key variable that in these simulations both is enhanced by and further induces inflammation.
   Conclusions: A relatively simple ABM such as the one reported in this study can provide new understanding of laryngeal wound healing and generate working hypotheses for further wet-lab studies.
C1 [Abbott, Katherine Verdolini] Univ Pittsburgh, Dept Commun Sci & Disorders, Sch Hlth & Rehabil Sci, Pittsburgh, PA 15260 USA.
   [Vodovotz, Yoram] Univ Pittsburgh, Dept Surg, Pittsburgh, PA 15260 USA.
   [Vodovotz, Yoram; Abbott, Katherine Verdolini] Univ Pittsburgh, Ctr Inflammat & Regenerat Modeling, Pittsburgh, PA 15260 USA.
   [Vodovotz, Yoram; Hebda, Patricia A.; Abbott, Katherine Verdolini] Univ Pittsburgh, McGowan Inst Regenerat Med, Pittsburgh, PA 15260 USA.
   [Hebda, Patricia A.] Univ Pittsburgh, Dept Otolaryngol, Pittsburgh, PA 15260 USA.
   [Hebda, Patricia A.] Univ Pittsburgh, Dept Pathol, Pittsburgh, PA 15260 USA.
   [Hebda, Patricia A.] Univ Pittsburgh, Dept Pediat Otolaryngol, Otolaryngol Wound Healing Lab, Pittsburgh, PA 15260 USA.
   [Abbott, Katherine Verdolini] Univ Pittsburgh, Voice Ctr, Pittsburgh, PA 15260 USA.
RP Abbott, KV (reprint author), Univ Pittsburgh, Dept Commun Sci & Disorders, Sch Hlth & Rehabil Sci, 4033 Forbes Tower, Pittsburgh, PA 15260 USA.
FU NIH [R01-DC-008290, P50-GM-53789]
FX From the Department of Communication Science and Disorders (Li, Hebda,
   Verdolini Abbott), the Department of Surgery (Vodovotz), the Center for
   Inflammation and Regenerative Modeling (Vodovotz, Verdolini Abbott), the
   McGowan Institute for Regenerative Medicine (Vodovotz, Hebda, Verdolini
   Abbott). the Department of Otolaryngology (Hebda). the Department of
   Pathology (Hebda), the Otolaryngology Wound Healing Laboratory,
   Department of Pediatric Otolaryngology (Hebda), and the University of
   Pittsburgh Voice Center (Verdolini Abbott). University of Pittsburgh.
   Pittsburgh, Pennsylvania. This work was funded by NIH grants
   R01-DC-008290 and P50-GM-53789.
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NR 104
TC 6
Z9 7
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD JUN
PY 2010
VL 119
IS 6
BP 412
EP 423
PG 12
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 609VR
UT WOS:000278686500009
PM 20583741
ER

PT J
AU Ogawa, F
   Hanamitsu, M
   Ayajiki, K
   Aimi, Y
   Okamura, T
   Shimizu, T
AF Ogawa, Fumio
   Hanamitsu, Masakazu
   Ayajiki, Kazuhide
   Aimi, Yoshinari
   Okamura, Tomio
   Shimizu, Takeshi
TI Effect of Nitric Oxide Synthase Inhibitor on Increase in Nasal Mucosal
   Blood Flow Induced by Sensory and Parasympathetic Nerve Stimulation in
   Rats
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE blood pressure; electrical nerve stimulation; nasal blood flow;
   nitrergic nerve; sensory nerve
ID SPHENOPALATINE GANGLION; ELECTRICAL-STIMULATION; ANESTHETIZED MONKEYS;
   NEURAL MECHANISM; RELAXING FACTOR; FIBERS; VASODILATATION; ARTERIES;
   NUCLEUS; PEPTIDE
AB Objectives: Neural control of nasal blood flow (NBF) has not been systematically investigated. The aim of the present study was to evaluate the effect of electrical stimulation of both sensory and parasympathetic nerves innervating the nasal mucosal arteries on NBF in rats.
   Methods: In anesthetized rats, nasociliary (sensory) nerves and postganglionic (parasympathetic) nerves derived from the right sphenopalatine ganglion were electrically stimulated. We measured NBF with a laser-Doppler flowmeter.
   Results: The nerve stimulation increased NBF on both sides and increased the mean arterial blood pressure. The increase in NBF was larger on the ipsilateral side than on the contralateral side. Hexamethonium bromide, a ganglion blocker, abolished the stimulation-induced pressure effect and the increase in NBF on the contralateral side, but did not abolish the increase in NBF on the ipsilateral side. The remaining increase in NBF was abolished by NG-nitro-L-arginine, a nitric oxide synthase inhibitor. Histochemical analysis with nicotinamide adenine dinucleotide phosphate diaphorase showed neuronal nitric oxide synthase containing nerves that innervate nasal mucosal arteries.
   Conclusions: Nitric oxide released from parasympathetic nitrergic nerves may contribute to an increase in NBF in rats. The afferent impulses induced by sensory nerve stimulation may lead to an increase in mean arterial blood pressure that is partly responsible for the increase in NBF.
C1 [Ogawa, Fumio; Hanamitsu, Masakazu; Shimizu, Takeshi] Shiga Univ Med Sci, Dept Otorhinolaryngol, Otsu, Shiga 5202192, Japan.
   [Aimi, Yoshinari] Shiga Univ Med Sci, Dept Morphol Sci, Otsu, Shiga 5202192, Japan.
   [Okamura, Tomio] Shiga Univ Med Sci, Dept Pharmacol, Otsu, Shiga 5202192, Japan.
RP Ogawa, F (reprint author), Shiga Univ Med Sci, Dept Otorhinolaryngol, Otsu, Shiga 5202192, Japan.
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NR 26
TC 3
Z9 4
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD JUN
PY 2010
VL 119
IS 6
BP 424
EP 430
PG 7
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 609VR
UT WOS:000278686500010
PM 20583742
ER

PT J
AU Zeitler, DM
   Glick, J
   Har-El, G
AF Zeitler, Daniel M.
   Glick, Joelle
   Har-El, Gady
TI Preoperative Embolization in Carotid Body Tumor Surgery: Is It Required?
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT Annual Meeting of the American-Head-and-Neck-Society/ Combined
   Otolaryngological Spring Meeting
CY MAY 28-31, 2009
CL Phoenix, AZ
SP Amer Head & Neck Soc
DE blood loss; carotid body tumor; paraganglioma; preoperative embolization
ID SURGICAL-MANAGEMENT; DEFINITIVE RADIOTHERAPY; NECK PARAGANGLIOMAS;
   EXPERIENCE; HEAD; CHEMODECTOMA; TRENDS
AB Objectives: We compared estimated blood loss (EBL) in patients who underwent surgical excision of carotid body tumors (CBTs) after preoperative superselective angiography with embolization (PSE) with that in patients who underwent excision of CBTs without PSE.
   Methods: We performed a retrospective chart review of a consecutive case series in a single surgeon's practice within an academic tertiary care medical center. Twenty-five patients underwent surgical resection of a CBT from 1989 to 2009. From 1989 to 1996, 10 consecutive patients had PSE of the CBT, whereas the subsequent 15 patients (1996 to 2009) had no PSE. Demographic data including age, sex, and tumor size were collected. The EBL was obtained from intraoperative records and operative notes dictated at the time of surgery. Tumor size was based on preoperative radiographic measurements by a senior radiologist and the surgeon.
   Results: In the 10 patients with PSE, the mean age was 41 years (range, 22 to 72 years) and the mean tumor size was 4.8 cm (range, 2.9 to 8.3 cm). The mean EBL was 305 mL (range, 50 to 1,000 mL); 2 patients had an EBL of more than 400 mL. In the 15 patients without PSE, the mean age was 43.7 years (range, 20 to 75 years) and the mean tumor size was 4.4 cm (range, 2.8 to 7.9 cm). The mean EBL was 265.6 mL (range, 40 to 900 nth); 2 patients had an EBL of more than 400 mL. There were no significant differences between the 2 groups with regard to age, tumor size, or EBL.
   Conclusions: Preoperative superselective angiography with embolization of a CBT does not lead to a significant reduction in intraoperative EBL.
C1 Lenox Hill Hosp, Dept Otolaryngol Head & Neck Surg, New York, NY 10021 USA.
   NYU, Sch Med, New York, NY USA.
RP Har-El, G (reprint author), 186 E 76th St,2nd Floor, New York, NY 10021 USA.
CR Abud DG, 2004, AM J NEURORADIOL, V25, P1457
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NR 31
TC 16
Z9 16
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD MAY
PY 2010
VL 119
IS 5
BP 279
EP 283
PG 5
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 599EG
UT WOS:000277892700001
PM 20524570
ER

PT J
AU Al-Sebeih, K
   Abu-Shara, KA
   Sobeih, A
AF Al-Sebeih, Khalid
   Abu-Shara, Khairy-Alhag
   Sobeih, Amro
TI Extraluminal Perforation Complicating Foreign Bodies in the Upper
   Aerodigestive Tract
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE esophagus; ingested foreign body; migration; penetration; pharynx;
   Zenker's diverticulum
ID PHARYNGEAL POUCH; ESOPHAGUS; BODY
AB Objectives: Ingestion of a foreign body is a common problem in nearly all otolaryngology practices. One of the uncommon complications of ingested foreign bodies is penetration and migration of the object, which may lead to serious morbidity and/or death. This study will evaluate the presentation, complications, and management of different sites of penetration.
   Methods: We present a retrospective study of a series of 11 patients who presented with a penetrating foreign body of the upper aerodigestive tract in the past 10 years.
   Results: All of the patients had radiologic evidence of a foreign body, but negative findings on rigid endoscopy. A computed tomographic scan was done to confirm the presence of a penetrating foreign body. The foreign body was lodged in the extrapharyngeal tissue in 6 patients, was lodged in the upper thyroid pole in 2 patients, had penetrated a Zenker's diverticulum in 2 patients, and had migrated to the thoracic retroesophageal tissue in 1 patient. All patients underwent extraction of the foreign body by an external approach.
   Conclusions: Although the occurrence is rare, impacted foreign bodies in the upper digestive tract can perforate and migrate into the soft tissue of the neck. In the presence of negative findings on endoscopy, a computed tomographic scan of the neck is essential for the prompt diagnosis and management of perforating foreign bodies.
C1 [Al-Sebeih, Khalid] Kuwait Univ, Fac Med, Dept Surg, Otolaryngol Div, Kuwait 72453, Kuwait.
   [Al-Sebeih, Khalid; Abu-Shara, Khairy-Alhag; Sobeih, Amro] Sabah Hosp, Zain Hosp, Dept Otolaryngol, Kuwait, Kuwait.
RP Al-Sebeih, K (reprint author), Kuwait Univ, Fac Med, Dept Surg, Otolaryngol Div, POB 17228, Kuwait 72453, Kuwait.
CR Al-Sebeih Khalid, 2006, Ear Nose Throat J, V85, P600
   Chee LWJ, 1999, ANN OTO RHINOL LARYN, V108, P177
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NR 15
TC 4
Z9 4
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD MAY
PY 2010
VL 119
IS 5
BP 284
EP 288
PG 5
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 599EG
UT WOS:000277892700002
PM 20524571
ER

PT J
AU Glade, R
   Vinson, K
   Richter, G
   Suen, JY
   Buckmiller, LM
AF Glade, Robert
   Vinson, Kimberly
   Richter, Gresham
   Suen, James Y.
   Buckmiller, Lisa M.
TI Endoscopic Management of Airway Venous Malformations With Nd:YAG Laser
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT 89th Annual Meeting of the American-Broncho-Esophagological-Association
CY MAY 28-29, 2009
CL Phoenix, AZ
SP Amer Broncho Esophagol Assoc
DE larynx; Nd:YAG laser; supraglottis; venous malformation
ID VASCULAR MALFORMATIONS; PHOTOCOAGULATION; TONGUE
AB Objectives: The neodymium:yttrium-aluminum-garnet (Nd:YAG) laser is a powerful tool in treating venous malformations (VMs) involving the upper airway. If left untreated, laryngeal VMs can lead to life-threatening airway obstruction. We aimed to evaluate the efficacy of endoscopic management of laryngeal VMs with the Nd:YAG laser.
   Methods: We performed a 12-year retrospective review in a tertiary referral center. Patient records were reviewed for demographics, presenting symptoms, area of involvement, age at first Nd:YAG laser therapy, total number of treatments, time between treatments, and treatment response.
   Results: Seventeen patients were treated endoscopically with an Nd:YAG laser for laryngeal VMs. The mean age at first treatment was 23.0 years (range, 18 to 45 years). The majority of patients presented with obstructive sleep apnea (58.8%), and 17.5% of patients presented with acute airway obstruction or stridor. The remaining patients presented with minor symptoms, including chronic cough and voice changes. The VMs involved the supraglottis, glottis, or both in 29%, 35%, and 35% of patients, respectively. An average of 4 treatments were required per patient (median, 3.5; range, 1 to 9). The time between treatments increased with each consecutive laser therapy, starting at a mean of 3.8 months between the first and second treatments to 21.7 months between the third and fourth. A marked reduction in VM size and symptom improvement were achieved in each patient after Nd:YAG therapy. Two complications (3%) were encountered among 66 total procedures.
   Conclusions: Endoscopic management of VMs using an Nd:YAG laser appears to be both effective and relatively safe. Multiple treatments are often required, but increased time can elapse between consecutive therapies. Use of the Nd:YAG laser for laryngeal VMs helps avoid tracheotomy and open surgical resection.
C1 [Buckmiller, Lisa M.] Univ Arkansas Med Sci, Dept Otolaryngol, Vasc Anomalies Team, Arkansas Childrens Hosp, Little Rock, AR 72202 USA.
   [Glade, Robert; Richter, Gresham; Suen, James Y.; Buckmiller, Lisa M.] Univ Arkansas Med Sci, Vasc Anomalies Ctr, Little Rock, AR 72202 USA.
   [Vinson, Kimberly] Vanderbilt Univ, Dept Otolaryngol Head & Neck Surg, Nashville, TN USA.
RP Buckmiller, LM (reprint author), Univ Arkansas Med Sci, Dept Otolaryngol, Vasc Anomalies Team, Arkansas Childrens Hosp, 800 Marshall St,Slot 836, Little Rock, AR 72202 USA.
CR Berenguer B, 1999, PLAST RECONSTR SURG, V104, P1, DOI 10.1097/00006534-199907000-00001
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   Persky MS, 2003, LARYNGOSCOPE, V113, P1885, DOI 10.1097/00005537-200311000-00005
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NR 11
TC 5
Z9 5
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD MAY
PY 2010
VL 119
IS 5
BP 289
EP 293
PG 5
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 599EG
UT WOS:000277892700003
PM 20524572
ER

PT J
AU Adachi, N
   Ito, K
   Sakata, H
AF Adachi, Nodoka
   Ito, Ken
   Sakata, Hideaki
TI Risk Factors for Hearing Loss After Pediatric Meningitis in Japan
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE Asian population; child; complication; hearing loss; meningitis; risk
   factor
ID BACTERIAL-MENINGITIS; CHILDREN
AB Objectives: We sought to identify predictors for hearing loss in Japanese children with meningitis.
   Methods: We analyzed 155 cases of pediatric meningitis without other entities causing hearing loss in children admitted to Saitama Children's Medical Center between 1990 and 2005 for potential risk factors for hearing loss, using multiple logistic regression. Auditory brain stem response tests were performed to evaluate hearing loss.
   Results: Of 155 children, 35 (23%) developed hearing loss (21 unilaterally and 14 bilaterally). Profound hearing loss (greater than 90 dB normal hearing level) occurred in 15 patients (9.7%; 4 unilaterally and 11 bilaterally). Of 112 patients with positive cerebrospinal fluid cultures, 27 (24%) developed hearing loss and 13 (12%) showed profound loss. Of 22 patients with Streptococcus pneumoniae meningitis, 11(50%) developed hearing loss and 7 (32%) showed profound loss. Of 54 patients with Haemophilus influenzae meningitis, 11(20%) developed hearing loss and 4 (7.4%) showed profound loss. High serum C-reactive protein levels and cerebrospinal fluid cultures positive for Streptococcus pneumoniae were identified as significant risk factors for hearing loss.
   Conclusions: A high serum C-reactive protein level was first identified as a risk factor for hearing impairment after pediatric meningitis.
C1 [Ito, Ken] Teikyo Univ, Dept Otolaryngol, Itabashi Ku, Tokyo 1738605, Japan.
   [Adachi, Nodoka; Sakata, Hideaki] Saitama Childrens Med Ctr, Div Otolaryngol, Saitama, Japan.
RP Ito, K (reprint author), Teikyo Univ, Dept Otolaryngol, Itabashi Ku, 2-11-1 Kaga, Tokyo 1738605, Japan.
EM itoken-tky@umin.ac.jp
CR Arditi M, 1998, PEDIATRICS, V102, P1087, DOI 10.1542/peds.102.5.1087
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   Eisenhut M, 2003, INFECTION, V31, P247, DOI 10.1007/s151010-003-3208-0
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   GUISCAFRE H, 1984, ANN OTO RHINOL LARYN, V93, P229
   Koomen I, 2003, PEDIATRICS, V112, P1049, DOI 10.1542/peds.112.5.1049
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NR 9
TC 3
Z9 5
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD MAY
PY 2010
VL 119
IS 5
BP 294
EP 296
PG 3
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 599EG
UT WOS:000277892700004
PM 20524573
ER

PT J
AU Su, CY
   Alswiahb, JN
   Hwang, CF
   Hsu, CM
   Wu, PY
   Huang, HH
AF Su, Chih-Ying
   Alswiahb, Jamil N.
   Hwang, Chung-Feng
   Hsu, Cheng-Ming
   Wu, Pei-Yin
   Huang, Hsun-Hsien
TI Endoscopic Laser Anterior Commissurotomy for Anterior Glottic Web:
   One-Stage Procedure
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT 19th World Congress of the
   International-Federation-of-Otorhinolaryngology-Societies
CY JUN 01-05, 2009
CL Sao Paulo, BRAZIL
SP Int Federat Otorhinolaryngol Soc
DE anterior glottic web; endoscopic laser anterior commissurotomy;
   laryngeal stenosis; laryngeal web
ID STRAP MUSCLE TRANSPOSITION; CONGENITAL LARYNGEAL WEB; TOPICAL
   MITOMYCIN-C; VOCAL FOLD; RABBIT MODEL; STENOSIS; MANAGEMENT;
   MARSUPIALIZATION; MEDIALIZATION; PREVENTION
AB Objectives: The conventional method for preventing web formation after anterior glottic web surgery is keel insertion. However, this presents risks of airway compromise and granulation tissue formation, which could necessitate tracheotomy in addition to a secondary procedure for keel removal. We introduce a novel, 1-stage endoscopic laser anterior commissurotomy for preventing anterior glottic web re-formation.
   Methods: Twenty patients with glottic webs involving the anterior commissure were studied. The lesions were removed by transoral carbon dioxide laser microsurgery. In all patients, the anterior glottic web was vaporized along with the inner perichondrium of the thyroid cartilage over the anterior commissure area, creating a raw vertical break "alley" between the anterior vocal folds that measured between 0.3 and 0.5 cm in width and between 0.8 and 2 cm in length. The preoperative and postoperative vocal folds and voice quality were evaluated by videostrobolaryngoscopy and voice recordings.
   Results: All 20 patients had anterior glottic webs ranging from 11 % to 64% of the length from the anterior commissure to the vocal process. None of the patients developed restenosis at the anterior commissure of a severity similar to that of the initial lesion during follow-up (mean, 13 months; range, 3 to 44 months). All patients except 1 reported satisfaction with their voice improvement. Outcome analysis revealed that partial re-formation of the web was noted in 4 patients.
   Conclusions: One-stage, endoscopic laser anterior commissurotomy was effective and relatively safe for removing glottic webs, for preventing anterior glottic web re-formation, and for improving vocal fold performance among our patients.
C1 [Su, Chih-Ying; Alswiahb, Jamil N.; Hwang, Chung-Feng; Hsu, Cheng-Ming; Wu, Pei-Yin; Huang, Hsun-Hsien] Chang Gung Univ, Coll Med, Chang Gung Mem Hosp, Kaohsiung Med Ctr, Kaohsiung, Taiwan.
   [Su, Chih-Ying] Chang Gung Univ, Coll Med, Dept Otolaryngol, Kaohsiung, Taiwan.
   [Su, Chih-Ying] Dr Su Voice Beauty Clin, Taipei, Taiwan.
RP Su, CY (reprint author), 2F,331,Fuxing N Rd, Taipei, Taiwan.
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NR 28
TC 3
Z9 4
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD MAY
PY 2010
VL 119
IS 5
BP 297
EP 303
PG 7
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 599EG
UT WOS:000277892700005
PM 20524574
ER

PT J
AU de Zinis, LOR
   Tonni, D
   Barezzani, MG
AF de Zinis, Luca Oscar Redaelli
   Tonni, Daniela
   Barezzani, Maria Grazia
TI Single-Stage Canal Wall-Down Tympanoplasty: Long-Term Results and
   Prognostic Factors
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE canal wall-down tympanoplasty; cholesteatoma; prognostic factor
ID PEDIATRIC CHOLESTEATOMA SURGERY; MIDDLE-EAR; ACQUIRED CHOLESTEATOMA;
   RETRACTION POCKETS; SURGICAL-TREATMENT; FOLLOW-UP; RESIDUAL
   CHOLESTEATOMA; PRIMARY RECONSTRUCTION; MASTOID OBLITERATION; RECURRENCE
   RATES
AB Objectives: We sought to identify factors associated with anatomic and functional results of canal wall down tympanoplasty.
   Methods: One hundred eighty-nine primary or relapsing cholesteatomas were consecutively operated on by a single surgeon. Cholesteatoma recurrence rates were evaluated. Predictive values of the patient, disease, and surgical characteristics on cholesteatoma recurrence were estimated. The effect of these variables on keratin pearl development, recurrent otorrhea or granulation tissue formation, and hearing function was tested.
   Results: The mean follow-up was 8 years (range, 4 to 15 years). The cholesteatoma relapse rate (+/- SE) estimated by the Kaplan-Meier method was 2.1% +/- 1.1%. No variables were associated with relapsing disease. The log-rank test showed a significantly higher probability of keratin pearls in male patients (16.7% versus 2.1%; p = 0.001), young patients (less than 16 years; 51.4% versus 6.2%; p = 0.0001), patients with unencapsulated cholesteatomas (19.5% versus 5.3%; p = 0.06), patients with petrous or accessory cellularity invasion (17.9% versus 7.1%; p = 0.02), and patients with overlay myringoplasty (25% versus 7.9%; p = 0.03). Recurrent otorrhea and granulation tissue were associated with homograft temporalis fascia myringoplasty (14.3% versus 3.8%; p = 0.04). The overall postoperative air-bone gap was within 20 dB in 30.7%; it was within 20 dB in 43.9% (47/107) for intact or reconstructed ossicular chains and in 13.4% (11/82) for nonreconstructed, eroded ossicular chains (p = 0.0001). The air-bone gap was within 20 dB in 42.6% (461108) when the mucosa of the tympanic cavity was normal and in 14.8% (12/81) when there was granulation tissue within the tympanic cavity (p = 0.0001).
   Conclusions: Single-stage canal wall down tympanoplasty is an appropriate treatment for acquired tympanomastoid cholesteatoma.
C1 [de Zinis, Luca Oscar Redaelli; Tonni, Daniela; Barezzani, Maria Grazia] Univ Brescia, Dept Otorhinolaryngol, I-25123 Brescia, Italy.
RP de Zinis, LOR (reprint author), Univ Brescia, Dept Otorhinolaryngol, Piazzale Spedali Civili 1, I-25123 Brescia, Italy.
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NR 66
TC 6
Z9 6
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD MAY
PY 2010
VL 119
IS 5
BP 304
EP 312
PG 9
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 599EG
UT WOS:000277892700006
PM 20524575
ER

PT J
AU Miller, ME
   Kirsch, C
   Canalis, RF
AF Miller, Mia E.
   Kirsch, Claudia
   Canalis, Rinaldo F.
TI Congenital Familial Fixation of the Malleus
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE conductive hearing loss; embryology; facial nerve abnormality; malleus;
   middle ear
ID CONDUCTIVE HEARING-LOSS; HEAD FIXATION; STAPEDECTOMY; HISTOPATHOLOGY;
   OTOSCLEROSIS; CHILDREN; SURGERY; INCUS
AB We present a familial association of radiographically and surgically demonstrated mallear fixation with concurrent stapedial abnormality and dehiscence of the facial nerve in a father and son, including history, physical findings, surgical findings, radiologic analyses, and a literature review. A 12-year-old boy presented with long-term left-sided conductive hearing loss, and was found to have mallear fixation and a dehiscent facial nerve on a computed tomographic (CT) scan of the temporal bone. Release of the malleus was performed at surgery, revealing hypermobility of the remaining ossicular chain. A repeat CT scan of the temporal bone showed successful release of the mallear head. The patient's father later presented with bilateral hearing loss, and a CT scan of the temporal bones showed bilateral osseous fixation of the mallear head to the tegmen and bilateral facial nerve dehiscences. He underwent right middle ear exploration, but release of the malleus was not performed because of the risk to the dehiscent facial nerve. The stapes crurae were found to be fill form at surgery. This is the first reported familial association of mallear fixation. Mallear fixation with facial nerve dehiscence and an abnormal stapes occurring in a parent and his child is interesting embryologically, and suggests that these anomalies may be genetically linked.
C1 [Miller, Mia E.; Canalis, Rinaldo F.] Univ Calif Los Angeles, David Geffen Sch Med, Div Head & Neck Surg, Los Angeles, CA 90095 USA.
   [Kirsch, Claudia] Ohio State Univ, Dept Radiol, Coll Med, Columbus, OH 43210 USA.
RP Miller, ME (reprint author), UCLA Head & Neck Surg, 10833 Le Conte Ave,62-237 CHS, Los Angeles, CA 90095 USA.
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NR 28
TC 0
Z9 0
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD MAY
PY 2010
VL 119
IS 5
BP 319
EP 324
PG 6
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 599EG
UT WOS:000277892700008
PM 20524577
ER

PT J
AU Hillel, AT
   Lin, LM
   Samlan, R
   Starmer, H
   Leahy, K
   Flint, PW
AF Hillel, Alexander T.
   Lin, Li-Mei
   Samlan, Robin
   Starmer, Heather
   Leahy, Kevin
   Flint, Paul W.
TI Inhaled Triamcinolone With Proton Pump Inhibitor for Treatment of Vocal
   Process Granulomas: A Series of 67 Granulomas
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT 89th Annual Meeting of the American-Broncho-Esophagological-Association
CY MAY 28-29, 2009
CL Phoenix, AZ
SP Amer Broncho Esophagol Assoc
DE gastroesophageal reflux; hyperfunctional voice abuse; inhaled steroid;
   proton pump inhibitor; speech therapy; vocal process granuloma
ID CONTACT GRANULOMA; LARYNX; ULCER; BUDESONIDE; THERAPY; ASTHMA; FOLD
AB Objectives: We sought to analyze the outcomes of vocal process granulomas treated with proton pump inhibitors and inhaled triamcinolone acetonide.
   Methods: We reviewed the medical records of patients with a diagnosis of contact granuloma or vocal process granuloma between 1995 and 2008. Data included age, gender, intubation history, reflux history, lesion location, previous treatment methods, treatment course, and recurrence. All patients were treated with daily or twice-daily protein pump inhibitors and inhaled triamcinolone acetonide (300 mu g 3 times a day).
   Results: Sixty-seven granulomas were diagnosed in 54 patients: 13 bilateral and 41 unilateral. Twenty patients, including all 11 women, had a recent history of intubation. Sixty-two granulomas in 50 patients were treated with triamcinolone and a proton pump inhibitor. Of the 57 granulomas that completed treatment, 5 (9%) did not respond (mean follow-up, 50 weeks; range, 30.3 to 78.3 weeks), 13 (22%) partially responded (mean follow-up, 11 weeks; range, 3 to 30 weeks), and 40 (69%) completely responded (mean follow-up, 21 weeks; range, 5.9 to 84.6 weeks). Three cases had recurrence: 2 nonresponders and 1 complete responder. One patient developed oral thrush.
   Conclusions: In this study, vocal process granulomas occurred more frequently in men, whereas women developed granulomas only after intubation. The anti-inflammatory action of inhaled triamcinolone combined with antireflux proton pump inhibitors successfully treats most vocal process granulomas with low rates of side effects and recurrence.
C1 [Hillel, Alexander T.; Samlan, Robin; Starmer, Heather; Leahy, Kevin; Flint, Paul W.] Johns Hopkins Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, Baltimore, MD 21205 USA.
   [Lin, Li-Mei] Johns Hopkins Univ, Sch Med, Dept Neurosurg, Baltimore, MD 21205 USA.
RP Flint, PW (reprint author), Oregon Hlth & Sci Univ, Dept Otolaryngol Head & Neck Surg, 3181 SW Sam Jackson Pk Rd, Portland, OR 97239 USA.
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NR 26
TC 8
Z9 8
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD MAY
PY 2010
VL 119
IS 5
BP 325
EP 330
PG 6
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 599EG
UT WOS:000277892700009
PM 20524578
ER

PT J
AU Jang, YJ
   Kwon, M
AF Jang, Yong Ju
   Kwon, Minsu
TI Modified Extracorporeal Septoplasty Technique in Rhinoplasty for
   Severely Deviated Noses
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE deviated nose; extracorporeal septoplasty; rhinoplasty
ID CROOKED NOSE; SEPTUM; RECONSTRUCTION; REPLACEMENT; DEFORMITIES; GRAFT
AB Objectives: Secure fixation of the reimplanted septum is critical for successful long-term aesthetic and functional outcomes following extracorporeal septoplasty (ECS). We describe the results of our modified ECS technique.
   Methods: This retrospective study involved 27 patients with a deviated nose who underwent our modified ECS method in rhinoplasty between June 2006 and January 2009. Anthropometric changes were assessed from preoperative and postoperative facial photographs. Patient satisfaction was evaluated, and nasal obstruction improvement was assessed on a visual analog scale.
   Results: Postoperative correction of the external nose deviation angle was statistically significant. Twenty-four patients (89%) were satisfied with the cosmetic outcome, and all 23 patients with moderate to severe preoperative nasal obstruction were satisfied with the postoperative improved nasal breathing.
   Conclusions: Our modified ECS fixation technique was easy to perform and effective in septorhinoplasty for severe septal deviation.
C1 [Jang, Yong Ju; Kwon, Minsu] Univ Ulsan, Coll Med, Dept Otolaryngol, Asan Med Ctr, Seoul 138736, South Korea.
RP Jang, YJ (reprint author), Univ Ulsan, Coll Med, Dept Otolaryngol, Asan Med Ctr, 388-1 Pungnap 2 Dong, Seoul 138736, South Korea.
CR Andre RF, 2006, LARYNGOSCOPE, V116, P1668, DOI 10.1097/01.mlg.0000233249.81424.20
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NR 14
TC 6
Z9 6
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD MAY
PY 2010
VL 119
IS 5
BP 331
EP 335
PG 5
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 599EG
UT WOS:000277892700010
PM 20524579
ER

PT J
AU Tsai, TY
   Su, CY
AF Tsai, Tsung-Yen
   Su, Chih-Ying
TI Surgical Technique of Transoral Marsupialization for the Treatment of
   Nasopharyngeal Branchial Cysts
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE marsupialization; nasopharyngeal cyst; pharyngeal branchial cyst
ID PARAPHARYNGEAL SPACE; CLEFT CYST; HISTOGENESIS; MANAGEMENT; EXCISION;
   TUMORS
AB Objectives: Nasopharyngeal branchial cysts (NBCs) are derived from a remnant of the branchial apparatus and originate from the lateral wall of the nasopharynx. Total excision of these cysts was the standard treatment in the past. We present a simpler and less invasive approach for NBC treatment, involving marsupialization, and report on its effectiveness and advantages.
   Methods: The surgical approach was transoral. A circular incision 2 to 3 cm in diameter was made directly through the inferior wall of the cyst. After the NBC was drained, its opening was widened with scissors. A disk of oropharyngeal mucosa and the connecting inferior wall of the cyst were excised together. The cut edges of the inner lining of the cyst and the oropharyngeal mucosa were approximated with sutures.
   Results: All 4 patients were female. One patient was observed because of poor cardiovascular health. The 3 patients who were managed surgically underwent successful transoral cyst marsupialization. The mean follow-up period was 21 months (range, 8 to 40 months). No obvious postoperative complication or recurrence was noted.
   Conclusions: Transoral marsupialization is a simple, effective, and less invasive method for treatment of NBCs.
C1 [Su, Chih-Ying] Chang Gung Mem Hosp, Kaohsiung Med Ctr, Dept Otolaryngol Head & Neck Surg, Niao Sung Hsiang, Kaohsiung Hsien, Taiwan.
   Chang Gung Univ, Coll Med, Kaohsiung Hsien, Taiwan.
RP Su, CY (reprint author), Chang Gung Mem Hosp, Kaohsiung Med Ctr, Dept Otolaryngol Head & Neck Surg, 12F-20,123-10,Ta Pei Rd, Niao Sung Hsiang, Kaohsiung Hsien, Taiwan.
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NR 22
TC 3
Z9 3
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD MAY
PY 2010
VL 119
IS 5
BP 336
EP 341
PG 6
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 599EG
UT WOS:000277892700011
PM 20524580
ER

PT J
AU Adelman, C
   Perez, R
   Nazarian, Y
   Freeman, S
   Weinberger, J
   Sohmer, H
AF Adelman, Cahtia
   Perez, Ronen
   Nazarian, Yoram
   Freeman, Sharon
   Weinberger, Jeffrey
   Sohmer, Haim
TI Furosemide Administered Before Noise Exposure Can Protect the Ear
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE cochlear amplifier; free radical; furosemide; hearing loss; noise;
   protection
ID INDUCED HEARING-LOSS; OTOACOUSTIC EMISSIONS; RADICAL SCAVENGERS;
   MAMMALIAN COCHLEA; MOUSE COCHLEA; HAIR-CELLS; TRAUMA; ACETYLCYSTEINE;
   OTOTOXICITY; MECHANICS
AB Objectives: We assessed the effect of furosemide administration on noise-induced hearing loss. This drug reversibly elevates the auditory threshold by inducing a temporary reduction of the endocochlear potential and thereby suppresses the cochlear amplifier and active cochlear mechanics.
   Methods: Mice were given a single injection of furosemide 30 minutes before exposure to 113 dB sound pressure level broadband noise. Control animals received saline solution. Furosemide was administered in other mice after the noise exposure. Auditory threshold shifts were assessed by recording auditory nerve brain stem evoked response (ABR) thresholds to broadband clicks.
   Results: The mean ABR threshold in the group injected with furosemide and exposed to temporary threshold shift (TTS)-producing noise was elevated by 20.4 +/- 12.3 dB, and that in the saline control group was elevated by 35.4 +/- 18.3 dB (p <0.02). The mean threshold elevations in the group injected with furosemide and exposed to permanent threshold shift (PTS)-producing noise and in the PTS saline control group were 15.0 +/- 10.3 dB and 27.0 +/- 12.7 dB, respectively (p <0.01). Similar results were obtained when the PTS was assessed with an 8-kHz tone burst ABR. There was no significant difference in the PTS between mice given a single injection of furosemide and those given saline solution after the noise; this finding shows that furosemide is not acting as an antioxidant.
   Conclusions: It appears that reversible hearing threshold elevation as a result of furosemide administration before noise exposure can reduce the YTS and PTS. This finding provides insight into the mechanism of noise-induced hearing loss.
C1 [Adelman, Cahtia; Freeman, Sharon; Sohmer, Haim] Hebrew Univ Jerusalem, Hadassah Med Sch, Dept Physiol, IL-91120 Jerusalem, Israel.
   [Adelman, Cahtia] Hadassah Univ Hosp, Speech & Hearing Ctr, Jerusalem, Israel.
   [Weinberger, Jeffrey] Hadassah Univ Hosp, Dept Otolaryngol Head & Neck Surg, Jerusalem, Israel.
   [Perez, Ronen; Nazarian, Yoram] Shaare Zedek Med Ctr, Dept Otolaryngol Head & Neck Surg, Jerusalem, Israel.
RP Sohmer, H (reprint author), Hebrew Univ Jerusalem, Hadassah Med Sch, Dept Physiol, POB 12272, IL-91120 Jerusalem, Israel.
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NR 27
TC 5
Z9 6
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD MAY
PY 2010
VL 119
IS 5
BP 342
EP 349
PG 8
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 599EG
UT WOS:000277892700012
PM 20524581
ER

PT J
AU Vyas, B
   Ishikawa, K
   Duflo, S
   Chen, X
   Thibeault, SL
AF Vyas, Bimal
   Ishikawa, Keiko
   Duflo, Suzy
   Chen, Xia
   Thibeault, Susan L.
TI Inhibitory Effects of Hepatocyte Growth Factor and Interleukin-6 on
   Transforming Growth Factor-beta 1 Mediated Vocal Fold
   Fibroblast-Myofibroblast Differentiation
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE alpha-smooth muscle actin; fibroblast; myofibroblast; transforming
   growth factor-beta 1; vocal fold; wound healing
ID SMOOTH MUSCLE ACTIN; EXTRACELLULAR-MATRIX; GENE-EXPRESSION; SCAR;
   FIBROSIS; REPAIR; MODEL; MICE
AB Objectives: The role of myofibroblasts in vocal fold scarring has not been extensively studied, partly because of the lack of a robust in vitro model. The objective of this investigation was to develop and characterize a myofibroblast in vitro model that could be utilized to investigate the molecular mechanism of myofibroblast differentiation and function in injured vocal fold tissue.
   Methods: Differentiation of human primary vocal fold fibroblasts (hVFFs) to myofibroblasts was stimulated with 5,10, or 20 ng/mL of recombinant transforming growth factor-beta 1 (TGF-beta 1). Cultures were analyzed by immunofluorescence and Western blotting, with an a smooth muscle actin (alpha-SMA) antibody used as a myofibroblast marker. Normal rabbit vocal folds were treated with 10 ng/mL of TGF-beta 1 for 7 days for in vivo corroboration. The effects of interleukin-6 (IL6) and hepatocyte growth factor (HGF) on myofibroblast differentiation were studied with Western blots.
   Results: The hVFFs demonstrated positive alpha-SMA labeling in cells stimulated by 10 and 20 ng/mL TGF-beta 1, indicating that hVFFs were capable of differentiation to myofibroblasts. Transforming growth factor-beta 1 induced the largest increase in alpha-SMA at 10 na/mL on day 5 of treatment. Both HGF and IL-6 suppressed the expression of TGF-beta 1-induced alpha-SMA.
   Conclusions: Our work characterizes a useful in vitro model of TGF-beta 1 mediated vocal fold fibroblast-myofibroblast differentiation. The extent of differentiation appears to be attenuated by HGF, suggesting a potential mechanism to support prior work indicating that HGF plays a protective role in reducing scar formation in vocal fold injuries. Paradoxically, IL-6, which has been shown to play a profibrotic role in dermal studies, also attenuated the TGF-beta 1 response.
C1 [Vyas, Bimal; Ishikawa, Keiko; Duflo, Suzy; Chen, Xia; Thibeault, Susan L.] Univ Wisconsin, Dept Surg, Div Otolaryngol Head & Neck Surg, Madison, WI 53705 USA.
RP Thibeault, SL (reprint author), Univ Wisconsin, Dept Surg, Div Otolaryngol Head & Neck Surg, 5107 WIMR,1111 Highland Ave, Madison, WI 53705 USA.
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NR 27
TC 14
Z9 14
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD MAY
PY 2010
VL 119
IS 5
BP 350
EP 357
PG 8
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 599EG
UT WOS:000277892700013
PM 20524582
ER

PT J
AU Butta, L
   Lombardi, D
   Marconi, A
   Nicolai, P
AF Butta, Laura
   Lombardi, Davide
   Marconi, Anna
   Nicolai, Piero
TI Transoral Excision of a Retropharyngeal Lymph Node Under Rigid
   Endoscopic Control
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE endoscopy; retropharyngeal lymph node; retropharyngeal space; transoral
   excision
ID SQUAMOUS-CELL CARCINOMA; THYROID-CANCER; METASTASIS; HEAD; NECK; SPACE
AB Different traditional surgical approaches. such as transcervical. transparotid, and mandible-splitting procedures. have been described to expose the retropharyngeal space. The introduction of the transoral approach. in selected patients. provided a direct and adequate access to the retropharyngeal space. permitting a feasible and minimally in procedure to remove retropharyngeal lymph nodes. We report a case of a transoral video-assisted approach for the excision of a retropharyngeal lymph node in a young man who had previously been treated at another in by surgery and radiotherapy for oral tongue cancer The endoscopic magnification allowed LIS to perform a meticulous and relatively bloodless dissection of the lesion from the surrounding tissues with a cleat identification of the anatomic structures. and therefore may represent a valid alternative to the use of a microscope or loupes to enhance vision A clear understanding of the anatomy of the retropharyngeal space and a high degree of surgical expertise ale required to perform a safe dissection of the lesion
C1 [Butta, Laura; Lombardi, Davide; Nicolai, Piero] Univ Brescia, Dept Otorhinolaryngol, I-25100 Brescia, Italy.
   [Marconi, Anna] Univ Brescia, Dept Radiol, I-25100 Brescia, Italy.
RP Lombardi, D (reprint author), Univ Brescia, Dept Otorhinolaryngol, Piazza Spedali Civili 1, I-25100 Brescia, Italy.
CR BALLANTYNE AJ, 1964, AM J SURG, V108, P500, DOI 10.1016/0002-9610(64)90143-6
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NR 10
TC 2
Z9 2
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD APR
PY 2010
VL 119
IS 4
BP 211
EP 214
PG 4
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 587GB
UT WOS:000276976900001
PM 20433018
ER

PT J
AU Berrettini, S
   Ravecca, F
   Volterrani, D
   Neri, E
   Forli, F
AF Berrettini, Stefano
   Ravecca, Francesca
   Volterrani, Duccio
   Neri, Emanuele
   Forli, Francesca
TI Imaging Evaluation in Otosclerosis: Single Photon Emission Computed
   Tomography and Computed Tomography
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE high-resolution computed tomography; otosclerosis; single photon
   emission computed tomography
ID SENSORINEURAL HEARING-LOSS; TYMPANO-COCHLEAR SCINTIGRAPHY; OF-THE-MONTH;
   TEMPORAL BONE; TYMPANOCOCHLEAR SCINTIGRAPHY; CT ANALYSIS;
   HISTOPATHOLOGY; IMPLANTATION; DENSITOMETRY; CAPSULE
AB Objectives: The aim of our study was to demonstrate the utility of diphosphonate bone single. photon emission computed tomography (SPECT) in diagnosing otosclerosis and to correlate the findings from SPECT with age. gender, and sensorineural hearing loss We also evaluated the ability of high-resolution computed tomography (HR-CT) in detecting otospongiotic and otosclerotic foci and correlated the HR-CT findings with the SPECT results
   Methods: Seventy-three subjects with surgically confirmed otosclerosis underwent SPECT. and 45 of the 73 patients also underwent HR-CT of the petrous bones
   Results: In the patient sample examined in this study. SPECT demonstrated a sensitivity of 95 2% and a specificity of about 96 7% By con elating the SPECT findings, we found an inverse relationship between bone radioactivity and age greater disease activity in younger patients and a direct relationship between bone radioactivity and the seventy of sensorineural impairment in younger patients In the 45 patients who also underwent HR-CT. the sensitivity of HR-CT (58%) was lower than that of SPECT, and the comparison between SPECT activity and the HR-CT findings (fenestral or retrofenestral type) demonstrated a statistically significant correlation between the morphological finding of bone demineralization (pericochlear foci) and a high uptake index
   Conclusions: The use of SPECT seems to be highly effective in differentiating normal from pathological petrous bone It also provides a quantitative evaluation of disease activity and shows a significant correlation with bone demineralization revealed by HR-CT
C1 [Berrettini, Stefano; Ravecca, Francesca; Forli, Francesca] Univ Pisa, Dept Neurosci, Otol Cochlear Implant Sect, Pisa, Italy.
   [Volterrani, Duccio] Univ Pisa, Reg Ctr Nucl Med, Pisa, Italy.
   [Neri, Emanuele] Univ Pisa, Dept Diagnost & Intervent Radiol, Pisa, Italy.
RP Berrettini, S (reprint author), Univ Pisana, Azienda Osped, Sez Otol, Osped Cisanello,Clin Otorinolaringoiat, Via Paradisa 2, I-56100 Pisa, Italy.
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NR 48
TC 8
Z9 8
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD APR
PY 2010
VL 119
IS 4
BP 215
EP 224
PG 10
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 587GB
UT WOS:000276976900002
PM 20433019
ER

PT J
AU Shiotani, A
   Tomifuji, M
   Araki, K
   Yamashita, T
   Saito, K
AF Shiotani, Akihiro
   Tomifuji, Masayuki
   Araki, Koji
   Yamashita, Taku
   Saito, Koichiro
TI Videolaryngoscopic Transoral En Bloc Resection of Supraglottic and
   Hypopharyngeal Cancers Using Laparoscopic Surgical Instruments
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE distending laryngoscope; endoscopic surgery; laryngeal preservation
   surgery; minimally invasive surgery; partial laryngectomy; partial
   pharyngectomy
ID LASER MICROSURGERY; SURGERY; LARYNGECTOMY
AB Objectives: We assessed the outcome of en bloc transoral resection of supraglottic and hypopharyngeal cancer using a distending laryngoscope with rigid videoendoscopic and laparoscopic surgical instruments
   Methods: We enrolled 30 patients with T1, T2, or selected T3 supraglottic and hypopharyngeal cancer in the study. 9 pal tents had under gone radiotherapy Neck dissections were performed for node-positive patients. Postoperative radiotherapy was administered to patients with multiple lymph node metastases or positive surgical margins
   Results: This surgical environment provided a Wide view of the operative field, facilitating bimanual manipulation of laparoscopic surgical instruments. and enabled us to perform en bloc transoral resection In 21 cases with a minimum follow-up period of I year (average. 33 months, range, 1 5 to 56 months), the 3-year disease-specific survival rate and the laryngeal preservation rate were each 95% Normal food intake was eventually possible in all cases Tracheostomy was performed for 2 patients as a prophylactic measure and for 1 patient because of a postoperative hemorrhage
   Conclusion: These results indicate that videolaryngoscopic transoral en bloc resection using laparoscopic surgical instruments can be one of the minimally invasive treatment options for supraglottic and hypopharyngeal cancers with satisfactory oncological outcome and postoperative laryngeal function
C1 [Shiotani, Akihiro; Tomifuji, Masayuki; Araki, Koji; Yamashita, Taku] Natl Def Med Coll, Dept Otolaryngol Head & Neck Surg, Tokorozawa, Saitama 3598513, Japan.
   [Saito, Koichiro] Keio Univ, Dept Otolaryngol Head & Neck Surg, Sch Med, Tokyo, Japan.
RP Shiotani, A (reprint author), Natl Def Med Coll, Dept Otolaryngol Head & Neck Surg, 3-2 Namiki, Tokorozawa, Saitama 3598513, Japan.
CR Ambrosch P, 1998, ANN OTO RHINOL LARYN, V107, P680
   Boudreaux BA, 2009, ARCH OTOLARYNGOL, V135, P397, DOI 10.1001/archoto.2009.24
   Iro H, 1998, ARCH OTOLARYNGOL, V124, P1245
   Martin A, 2008, LARYNGOSCOPE, V118, P398, DOI 10.1097/MLG.0b013e31815aeda3
   Sasaki CT, 2006, ANN OTO RHINOL LARYN, V115, P93
   SHIOTANI A, 2008, PRACT OTOL, V101, P68
   Steiner W, 2000, ENDOSCOPIC LASER SUR, P33
   Vilaseca I, 2004, HEAD NECK-J SCI SPEC, V26, P953, DOI 10.1002/hed.20074
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NR 10
TC 8
Z9 8
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD APR
PY 2010
VL 119
IS 4
BP 225
EP 232
PG 8
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 587GB
UT WOS:000276976900003
PM 20433020
ER

PT J
AU Choby, G
   Trojanowski, A
   Johnson, S
   Goldenberg, D
AF Choby, Garret
   Trojanowski, Andrzej
   Johnson, Samuel
   Goldenberg, David
TI Use of Double Electrode Pads for Intraoperative Monitoring of the
   Recurrent Laryngeal Nerve
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE neuromonitoring; recurrent laryngeal nerve; surface electrode
ID THYROID-SURGERY; INJURY; ELECTROMYOGRAPHY
AB We describe a novel technique using double electrode pads for intraoperative neuromonitoring of the recurrent laryngeal nerve This is a no setup of intraoperative neuromonitoring that helps protect against faulty readings due to tube migration during surgery and allows for the recording of "side-specific" recurrent laryngeal nerve in This method has not been previously described in the literature This on approach to neuromonitoring helps guard against tube migration, simplifies the intubation process. allows for the acquisition of side-specific information. and is less expensive than use of commercially available integrated endotracheal tubes
C1 [Choby, Garret; Johnson, Samuel; Goldenberg, David] Penn State Hershey Med Ctr, Dept Otolaryngol, Hershey, PA 17033 USA.
   [Trojanowski, Andrzej] Penn State Hershey Med Ctr, Dept Anesthesia, Hershey, PA 17033 USA.
RP Goldenberg, D (reprint author), Penn State Hershey Med Ctr, Dept Surg, Div Otolaryngol Head & Neck Surg, 500 Univ Dr,MCH091, Hershey, PA 17033 USA.
CR Aytac B, 2005, SAUDI MED J, V26, P1746
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   Johnson S, 2008, OTOLARYNG CLIN N AM, V41, P1147, DOI 10.1016/j.otc.2008.05.006
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NR 14
TC 0
Z9 0
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD APR
PY 2010
VL 119
IS 4
BP 233
EP 235
PG 3
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 587GB
UT WOS:000276976900004
PM 20433021
ER

PT J
AU Man, LX
   Statham, MM
   Rosen, CA
AF Man, Li-Xing
   Statham, Melissa M.
   Rosen, Clark A.
TI Mucosal Bridge and Pitting of the True Vocal Fold: An Unusual
   Complication of Cidofovir Injection
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT 89th Annual Meeting of the American-Broncho-Esophagological-Association
CY MAY 28-29, 2009
CL Phoenix, AZ
SP Amer Broncho Esophagol Assoc
DE cidofovir; recurrent respiratory papillomatosis; vocal fold
ID RECURRENT RESPIRATORY PAPILLOMATOSIS; INDOLE-3-CARBINOL;
   PHARMACOKINETICS; SYSTEM
AB We describe a unique complication of intralaryngeal cidofovir injection and present the case of a patient with recurrent respiratory papillomatosis in whom both a mucosa! bridge and a pit of the true vocal fold developed after intralaryngeal cidofovir injection A 40-year-old man presented with laryngeal papillomatosis 19 years after being treated with surgery and adjuvant radiotherapy for leiomyosarcoma of the cervical esophagus The patient underwent 5 papillomatosis excisions combined with subepithelial injections of miaow to the bilateral true vocal folds at a concentration of 5 mg/mL without any complications lie subsequently received 2 higher-dose cidofovir treatments 6 weeks apart because of a poor response to the previous treatments Two months later, there was evidence of a large mucosal bridge along the free edge of the right vocal fold and a deep pit in the lateral aspect of the same vocal fold We conclude that repeated high-dose intralesional injection of cidofovir may result in significant morphological changes to the vocal fold, most likely due to mucosal injury
C1 [Man, Li-Xing; Statham, Melissa M.; Rosen, Clark A.] Univ Pittsburgh, Sch Med, Dept Otolaryngol, Voice Ctr, Pittsburgh, PA USA.
RP Rosen, CA (reprint author), UPMC, Mercy Hosp, Bldg B,Suite 11500,1400 Locust St, Pittsburgh, PA 15219 USA.
CR Chadha NK, 2007, OTOLARYNG HEAD NECK, V136, P863, DOI 10.1016/j.otohns.2006.09.007
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   Lee AS, 2004, J VOICE, V18, P551, DOI 10.1016/j.jvoice.2003.07.007
   Naiman AN, 2004, LARYNGOSCOPE, V114, P1151, DOI 10.1097/00005537-200407000-00004
   Rosen CA, 1998, OTOLARYNG HEAD NECK, V118, P810, DOI 10.1016/S0194-5998(98)70274-8
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NR 14
TC 2
Z9 2
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD APR
PY 2010
VL 119
IS 4
BP 236
EP 238
PG 3
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 587GB
UT WOS:000276976900005
PM 20433022
ER

PT J
AU Bakthavachalam, S
   Schroeder, JW
   Holinger, LD
AF Bakthavachalam, Sivi
   Schroeder, James W., Jr.
   Holinger, Lauren D.
TI Diagnosis and Management of Type I Posterior Laryngeal Clefts
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT Annual Meeting of the American-Society-of-Pediatric-Otolaryngology
CY MAY 24, 2009
CL Seattle, WA
SP Amer Soc Pediat Otolaryngol
DE aspiration dysphagia; pediatric airway; posterior laryngeal cleft
ID LARYNGOTRACHEOESOPHAGEAL CLEFTS; REPAIR
AB Objectives: We review the diagnosis and management of type I posterior laryngeal clefts (PLCs)
   Methods: We performed a retrospective study at tertiary-care children's hospital of children who were diagnosed with a PLC between January 2003 and August 2008 We studied concurrent airway anomalies. comorbidities. presenting symptoms, age at the time of aspiration resolution. and rate of aspiration resolution
   Results: Sixty-seven children with PLCs were identified (41 boys and 26 girls) Filly-nine had type I clefts. 6 had type II and 2 had type III. Of the 59 type I cases. 15 (25 4%) were surgically repaired by endoscopy Eleven of these 15 children (73 3%) have had symptomatic improvement since the surgery. and 7 of those 11 (63 6%) ale tolerating thin liquids by mouth Two of the 15 (133%) displayed no improvement with still:cry. and 2 of the 15 (13 3%) were lost to follow-up Forty-four of the 59 type 1 clefts (74 6%) were managed nonsurgically Twenty of these 44 children (45 5%) did not present with aspiration Twenty-four of the 44 (54 5%) presented with aspiration. and 16 of the 24 (66 7%) are now tolerating thin liquids by mouth Seven of these 24 patients (29 2%) are still aspirating. and I has died The average time to resolution of aspiration was 7 8 months tor the surgical group and 13 6 months for the nonsurgical group (p = 0 19). In the surgical group. the average age at resolution of aspiration for patients who received their diagnosis at 0 to 6 months of age was 21 5 months, that for those with a diagnosis at 6 (012 months was 27 3 months, and that for those with a diagnosis at older than 12 months was 27 3 months (p = 0 31) In the nonsurgical group, the average age at resolution of aspiration for patients who received their diagnosis at 0 to 12 months of age was 15 8 months, that for those with a diagnosis at 12 to 24 months was 273 months, and that for those with a diagnosis at older than 24 months was 773 months (p = 0 0015)
   Conclusions: We found that I) the reported incidence of type 1 PLCs is increasing. 2) type 1 PLCs can often present without clinical aspiration, 3) aspiration caused by type I PLCS can be managed medically or surgically, and 4) operative in is advantageous for patients who have severe symptoms in who have persistent aspiration abet 2 years of age
C1 [Bakthavachalam, Sivi] Northwestern Univ, Div Pediat Otolaryngol, Childrens Mem Hosp, Feinberg Sch Med, Chicago, IL 60614 USA.
   Northwestern Univ, Feinberg Sch Med, Dept Otolaryngol Head & Neck Surg, Chicago, IL 60614 USA.
RP Schroeder, JW (reprint author), Northwestern Univ, Div Pediat Otolaryngol, Childrens Mem Hosp, Feinberg Sch Med, 2300 Childrens Plaza,Box 25, Chicago, IL 60614 USA.
CR Ahluwalia S, 2004, J LARYNGOL OTOL, V118, P648
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   Kubba H, 2005, ANN OTO RHINOL LARYN, V114, P309
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NR 23
TC 5
Z9 5
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD APR
PY 2010
VL 119
IS 4
BP 239
EP 248
PG 10
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 587GB
UT WOS:000276976900006
PM 20433023
ER

PT J
AU Fang, R
   Sun, JW
   Hu, YM
   Yao, K
   Hu, W
AF Fang, Rui
   Sun, Jingwu
   Hu, Yanming
   Yao, Kun
   Hu, Wei
TI Endoscopic Removal of Esophageal Impacted Dentures
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE denture; esophageal foreign body; esophagoscopy
ID FOREIGN-BODIES; MANAGEMENT
AB Objectives: A retrospective study was conducted on 6 patients with esophageal impacted dentures removed via rigid esophagoscopy
   Methods: Six patients with esophageal impacted dentures wet e treated in our department, and the following technique was successfully performed With the patients under general anesthesia, we inserted the endoscope to visualize the impacted dentures. fixed them with forceps. and then stuffed several cotton slivers soaked in saline solution into the esophagus around the dentures with another forceps Then we extracted the dentures from the esophagus.
   Results: All dentures were extracted through esophagoscopy, and thew were no severe complications except for I case of esophageal hematoma
   Conclusions: The dilation method using, saline solution soaked cotton slivers is relatively safe and effective in removing impacted dentures from the esophagus. avoiding open surgery and possible perforation
C1 [Fang, Rui; Sun, Jingwu; Hu, Yanming] Anhui Med Univ, Affiliated Anhui Prov Hosp, Dept Otolaryngol Head & Neck Surg, Hefei 230001, Anhui, Peoples R China.
   [Yao, Kun; Hu, Wei] Fuyang Peoples Hosp, Dept Otolaryngol, Fuyang, Peoples R China.
RP Sun, JW (reprint author), Anhui Med Univ, Affiliated Anhui Prov Hosp, Dept Otolaryngol Head & Neck Surg, Lujiang Rd 17, Hefei 230001, Anhui, Peoples R China.
CR Conners GP, 1997, PEDIATR EMERG CARE, V13, P154, DOI 10.1097/00006565-199704000-00017
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   NWAFO DC, 1980, ANN OTO RHINOL LARYN, V89, P129
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   WEBB WA, 1995, GASTROINTEST ENDOSC, V41, P39, DOI 10.1016/S0016-5107(95)70274-1
NR 11
TC 3
Z9 3
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD APR
PY 2010
VL 119
IS 4
BP 249
EP 251
PG 3
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 587GB
UT WOS:000276976900007
PM 20433024
ER

PT J
AU Kim, SC
   Kim, SH
   Kim, BY
AF Kim, Sang Cheol
   Kim, Se-Heon
   Kim, Benjamin Youngho
TI Successful Decannulation of T-tubes According to Type of Tracheal
   Stenosis
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT 89th Annual Meeting of the American-Broncho-Esophagological-Association
CY MAY 28-29, 2009
CL Phoenix, AZ
SP Amer Broncho Esophagol Assoc
DE decannulation; tracheal stenosis; T-tube
ID MANAGEMENT
AB Objectives: Although the T-tube has been widely used as a therapeutic method for treatment of tracheal stenosis, predictors for success have not been much studied. The authors analyzed several factors to search for a factor that would be useful as a prognostic indicator for successful decannulation
   Methods: A total of 41 patients who underwent T-tube insertion from 1995 to 2004 at Yonsei University Health System were included The medical records were reviewed retrospectively, and several factors regarding the type of stenosis were evaluated
   Results: Age, sex, and multiplicity and severity of stenoses (p = 0 860) were not significantly related to successful decannulation The longitudinal extent of stenosis had a significant influence on success (p = 0 035). and cases with a greater circumferential involvement tended to result in decannulation failure (p = 0 084)
   Conclusions: The severity of stenosis did not have a statistically significant relationship to the decannulation rate, although it was closely related to the patient's symptoms The longitudinal extent and the circumferential Involvement of stenosis were found to be correlated to the success rate and represented the extent of the damaged mucosal area Therefore, it was assumed that the extent of the damaged mucosal area could be more important than the area of the granulation tissue or the patients' symptoms in predicting the decannulation of T-tubes
C1 [Kim, Sang Cheol; Kim, Se-Heon; Kim, Benjamin Youngho] Yonsei Univ, Coll Med, Dept Otorhinolaryngol, Seoul 120752, South Korea.
RP Kim, BY (reprint author), Yonsei Univ, Coll Med, Dept Otorhinolaryngol, Sinchon Dong 134, Seoul 120752, South Korea.
CR Brichet A, 1999, EUR RESPIR J, V13, P888, DOI 10.1034/j.1399-3003.1999.13d32.x
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   Liu HC, 2002, EUR J CARDIO-THORAC, V21, P326, DOI 10.1016/S1010-7940(01)01098-3
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   Nouraei SAR, 2007, LARYNGOSCOPE, V117, P1073, DOI 10.1097/MLG.0b013e318050ca12
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NR 14
TC 2
Z9 2
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD APR
PY 2010
VL 119
IS 4
BP 252
EP 257
PG 6
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 587GB
UT WOS:000276976900008
PM 20433025
ER

PT J
AU Lee, KYS
   van Hasselt, CA
   Tong, MCF
AF Lee, Kathy Y. S.
   van Hasselt, Charles Andrew
   Tong, Michael C. F.
TI Age Sensitivity in the Acquisition of Lexical Tone Production: Evidence
   From Children With Profound Congenital Hearing Impairment After Cochlear
   Implantation
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE Cantonese; cochlear implant; lexical tone acquisition; sensitive age
ID CANTONESE-SPEAKING CHILDREN; PHONOLOGICAL ABILITIES; PERCEPTION
AB Objectives: This study investigated the effects of implant experience and age at implantation on the Cantonese tone production of children with cochlear implants The study also examined whether there was a particular age at which children were more responsive to acquiring tones
   Methods: The study included 45 children who had received unilateral cochlear implants at a mean age of 65 56 months The subjects were grouped according to their age at cochlear implantation and were assessed annually for 5 years thereafter A picture-naming task was used to measure their tone production performance
   Results: A simple effect of age at implantation was significant at all testing intervals except at the preoperative data point Children who were younger than 4 years of age when they received their implants scored significantly higher than did the 2 older groups at various testing intervals A significant simple effect of implant experience was also found Progress was most striking in children who received their implants before the age of 4 years
   Conclusions: For the most effective acquisition of Cantonese lexical tones, children should undergo early cochlear implantation For children who receive implants before the age of 4 years. benefits are noted in tone production ability in terms of a faster rate of improvement within a shorter period of time.
C1 [Lee, Kathy Y. S.] Chinese Univ Hong Kong, Dept Otorhinolaryngol Head & Neck Surg, Prince Wales Hosp, Shatin, Hong Kong, Peoples R China.
   Chinese Univ Hong Kong, Inst Human Communicat Res, Prince Wales Hosp, Shatin, Hong Kong, Peoples R China.
RP Lee, KYS (reprint author), Chinese Univ Hong Kong, Dept Otorhinolaryngol Head & Neck Surg, Prince Wales Hosp, Shatin, Hong Kong, Peoples R China.
RI LEE, Kathy/A-7745-2011
CR CHEUNG DMC, 2000, COCHLEAR IMPLANTS, P72
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   Lee J, 2005, AM BOOK REV, V26, P30
   Lee KYS, 2007, EAR HEARING, V28, p34S, DOI 10.1097/AUD.0b013e31803154e1
   Lee KYS, 2002, INT J PEDIATR OTORHI, V63, P137, DOI 10.1016/S0165-5876(02)00005-8
   Manrique M, 1999, INT J PEDIATR OTORHI, V49, pS193
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   Xu L, 2004, ACTA OTO-LARYNGOL, V124, P363, DOI 10.1080/00016480410016351
NR 20
TC 7
Z9 7
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD APR
PY 2010
VL 119
IS 4
BP 258
EP 265
PG 8
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 587GB
UT WOS:000276976900009
PM 20433026
ER

PT J
AU Al-Qudah, M
   Rashdan, Y
AF Al-Qudah, Mohannad
   Rashdan, Yasser
TI Role of Dexamethasone in Reducing Pain After Endoscopic Sinus Surgery in
   Adults: A Double-Blind Prospective Randomized Trial
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE acetaminophen; analgesia; dexamethasone; endoscopic sinus surgery;
   postoperative pain
ID POSTOPERATIVE PAIN
AB Objectives: We sought to study postoperative pain after endoscopic sinus surgery and to evaluate the efficacy of dexamethasone sodium phosphate in reducing pain and rescue analgesic requirements
   Methods: In a prospective. double-blind, placebo-controlled clinical trial, 62 patients with chronic rhinosinusitis who were undergoing general anesthesia for endoscopic sinus surgery were randomized to receive either 8 mu (2 mL) of intravenous dexamethasone sodium phosphate or 2 mL of saline solution at the time of induction of anesthesia After surgery, the patients were observed for 24 hours and were given 1 g of acetaminophen every 6 hours Pain severity was reported immediately and 6 and 24 hours after surgery on a 10-cm visual analog scale The need or rescue analgesia with tramadol hydrochloride was recorded and compared between the two groups
   Results: The two groups were matched by demographic data, clinical indications, and intraoperative details The average postoperative pain severity scores at the 3 time intervals were 3 6. 2. and I in the dexamethasone group and 3 6. 2 5. and 1 6 in the saline solution group These differences were not statistically significant Ten patients in the dexamethasone group required rescue analgesia. compared to 12 in the saline solution group The average patient required 0.53 doses of rescue analgesic in the dexamethasone group, versus 0.67 doses in the saline solution group Again, these differences were not statistically significant
   ZConclusions: Dexamethasone injection at the time of induction of general anesthesia is not superior to placebo in controlling early postoperative pain in patients who undergo endoscopic sinus surgery
C1 [Al-Qudah, Mohannad] Jordan Univ Sci & Technol, Dept Special Surg, Div Otolaryngol Head & Neck Surg, Irbid 22110, Jordan.
   [Rashdan, Yasser] Jordan Univ Sci & Technol, Dept Anesthesiol, Irbid 22110, Jordan.
RP Al-Qudah, M (reprint author), Jordan Univ Sci & Technol, Dept Special Surg, Div Otolaryngol Head & Neck Surg, POB 3030, Irbid 22110, Jordan.
CR Friedman M, 1996, LARYNGOSCOPE, V106, P1382, DOI 10.1097/00005537-199611000-00014
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   Kemppainen T, 2006, LARYNGOSCOPE, V116, P2125, DOI 10.1097/01.mlg.0000239108.12081.35
   Kemppainen TP, 2007, LARYNGOSCOPE, V117, P1434, DOI 10.1097/MLG.0b013e3180600a16
   McCafferty J, 1981, Br J Clin Pharmacol, V12, P434
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NR 8
TC 6
Z9 6
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD APR
PY 2010
VL 119
IS 4
BP 266
EP 269
PG 4
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 587GB
UT WOS:000276976900010
PM 20433027
ER

PT J
AU Kerschner, JE
   Erdos, G
   Hu, FZ
   Burrows, A
   Cioffi, J
   Khampang, P
   Dahlgren, M
   Hayes, J
   Keefe, R
   Janto, B
   Post, JC
   Ehrlich, GD
AF Kerschner, Joseph E.
   Erdos, Geza
   Hu, Fen Ze
   Burrows, Amy
   Cioffi, Joseph
   Khampang, Pawjai
   Dahlgren, Margaret
   Hayes, Jay
   Keefe, Randy
   Janto, Benjamin
   Post, J. Christopher
   Ehrlich, Garth D.
TI Partial Characterization of Normal and Haemophilus influenzae-Infected
   Mucosal Complementary DNA Libraries in Chinchilla Middle Ear Mucosa
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE cDNA library; chinchilla; leukotriene; molecular phylogeny; otitis media
ID ACUTE OTITIS-MEDIA; TISSUE DISTRIBUTION; CYSLT(2) RECEPTOR; IN-VITRO;
   LEUKOTRIENE; EXPRESSION; IDENTIFICATION; EPITHELIUM; CLONING; CELLS
AB Objectives: We sought to construct and partially characterize complementary DNA (cDNA) libraries prepared from the middle ear mucosa (M EM) of chinchillas to better understand pathogenic aspects of in and inflammation. particularly with respect to leukotriene biogenesis and response
   Methods: Chinchilla MEM was harvested from controls and after middle ear inoculation with nontypeable Haemophilus influenzae RNA was extracted to generate cDNA libraries Randomly selected clones were subjected to sequence analysis to characterize the libraries and to provide DNA sequence for phylogenetic analyses Reverse transcription polymerase chain reaction of the RNA pools was used to generate cDNA sequences corresponding to genes associated with leukotriene biosynthesis and metabolism
   Results: Sequence analysis of 921 randomly selected clones from the uninfected MEM cDNA library produced approximately 250,000 nucleotides of almost entirely novel sequence data Searches of the GenBank database with the Basic Local Alignment Search Tool provided for identification of 515 unique genes expressed in the MEM and not previously described in chinchillas. In almost all cases. the chinchilla cDNA sequences displayed much greater homology to human or other primate genes than with rodent species Genes associated with leukotriene metabolism were present in both normal and infected MEM
   Conclusions: Based on both phylogenetic comparisons and gene expression similarities with humans, chinchilla MEM appears to be an excellent model for the study of middle ear inflammation and in The higher degree of sequence similarity between chinchillas and humans compared to chinchillas and rodents was unexpected The cDNA libraries from normal and infected chinchilla NI EM will serve as useful molecular tools in the study of otitis media and should yield important information with respect to middle ear pathogenesis
C1 [Kerschner, Joseph E.; Burrows, Amy; Cioffi, Joseph; Khampang, Pawjai] Childrens Hosp Wisconsin, Med Coll Wisconsin, Dept Otolaryngol & Commun Sci, Milwaukee, WI 53226 USA.
   [Kerschner, Joseph E.] Childrens Hosp Wisconsin, Med Coll Wisconsin, Div Pediat Otolaryngol, Milwaukee, WI 53226 USA.
   [Erdos, Geza; Hu, Fen Ze; Dahlgren, Margaret; Hayes, Jay; Keefe, Randy; Janto, Benjamin; Post, J. Christopher; Ehrlich, Garth D.] Allegheny Singer Res Inst, Ctr Genom Sci, Pittsburgh, PA 15212 USA.
RP Kerschner, JE (reprint author), Childrens Hosp Wisconsin, Med Coll Wisconsin, Dept Otolaryngol & Commun Sci, 9000 W Wisconsin Ave, Milwaukee, WI 53226 USA.
RI Janto, Benjamin/E-7459-2010
FU National Institutes of Health [DC00192, DC007903, DC02148, DC04173];
   HRSA [DC05659]; National Institute on Deafness and Other Communication
   Disorders; Allegheny Singer Research Institute
FX From the Department of Otolaryngology and Communication Sciences
   (Kerschner. Burrows. Cioffi. Khampang) and the Division of Pediatric
   Otolaryngology (Kerschner), Medical College of Wisconsin. Children's
   Hospital of Wisconsin. Milwaukee. Wisconsin, and the Center for Genomic
   Sciences. Allegheny-Singer Research Institute. Pittsburgh. Pennsylvania
   (Ea dos. Hu.Dahlgren. Hayes. Keefe. Panto, Post. Ehrlich) Supported by
   National Institutes of Health grants DC00192 and DC007903 (Kerschner).
   DC02148. DC04173. and HRSA (Ehrlich). and DC05659 (Post) from the
   National Institute on Deafness and Other Communication Disorders and by
   the Allegheny Singer Research Institute This study was performed in
   accordance with the PHS Policy on Humane Care and Use of Laboratory
   Animals. the NIH Guide for the Care and Use Laboratory Animals,and the
   Animal Welfare Act (7 U S C et sec!). the an use protocol was approved
   by the Institutional at An Care and Use Committee (IACUC) of the
   Allegheny-Singer Research Institute
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NR 24
TC 2
Z9 2
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD APR
PY 2010
VL 119
IS 4
BP 270
EP 278
PG 9
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 587GB
UT WOS:000276976900011
PM 20433028
ER

PT J
AU Broniatowski, M
   Moore, NZ
   Grundfest-Broniatowski, S
   Tucker, HM
   Lancaster, E
   Krival, K
   Hadley, AJ
   Tyler, DJ
AF Broniatowski, Michael
   Moore, Nina Z.
   Grundfest-Broniatowski, Sharon
   Tucker, Harvey M.
   Lancaster, Ellen
   Krival, Kate
   Hadley, Aaron J.
   Tyler, Dustin J.
TI Paced Glottic Closure for Controlling Aspiration Pneumonia in Patients
   With Neurologic Deficits of Various Causes
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT 89th Annual Meeting of the American-Broncho-Esophagological-Association
CY MAY 28-29, 2009
CL Phoenix, AZ
SP Amer Broncho Esophagol Assoc
DE aspiration pneumonia; glottic closure; neurologic deficit; recurrent
   laryngeal nerve stimulation
ID MULTIPLE-SCLEROSIS; DYSPHAGIA; STROKE; MECHANISMS; CARE
AB Objectives: We undertook to determine whether paced vocal fold adduction can check aspiration in patients with various neurologic conditions
   Methods: Five patients with fluoroscopically documented aspiration and repeated pneumonias were em oiled Two previously reported patients with hemispheric stroke were compared to 3 additional subjects with ham stem basal ganglia and cerebellar stroke, cerebral palsy, and multiple sclerosis A modified Vocare stimulator was implanted subcutaneously and linked to the ipsilateral recurrent laryngeal nerve via pen neural electrodes Vocal fold adduction and glottic closure were effected with pulse trains (42 Hz, 1 2 mA: 188 to 560 mu s) and recorded with Enhanced Image J Fluoroscopy results with and without stimulation were assessed by 2 independent blinded reviewers. Pneumonia rates were compared before, during, and after the 6- to 12-month enrollment periods
   Results: There was statistically significant vocal fold adduction (p < 0 05) for all patients. further verified with bolus arrest (p < 0 05 for thin liquids. thick liquids. and puree depending On the speech-language pathologist) Pneumonia was prevented in 4 of the 5 patients during enrollment In the fifth patient. who had brain stem basal ganglia and cerebellar stroke, we were unable to completely seal the glottis and open the cricopharyngeus enough to handle his secretions
   Conclusions: Vocal fold pacing for aspiration pneumonia from a variety of neurologic insults appeals to be appropriate as long as the glottis can be sealed It is not sufficient when the cricopharyngeus must be independently opened.
C1 [Broniatowski, Michael; Tucker, Harvey M.] Case Western Reserve Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, Cleveland, OH 44106 USA.
   [Moore, Nina Z.; Hadley, Aaron J.; Tyler, Dustin J.] Case Western Reserve Univ, Dept Biomed Engn, Cleveland, OH 44106 USA.
   [Grundfest-Broniatowski, Sharon] Case Western Reserve Univ, Dept Gen Surg, Cleveland Clin, Lerner Coll Med, Cleveland, OH 44106 USA.
   [Lancaster, Ellen] Univ Hosp Hlth Syst, St Vincent Char Hosp, Cleveland, OH USA.
   [Krival, Kate] Kent State Univ, Sch Speech Pathol & Audiol, Kent, OH 44242 USA.
RP Broniatowski, M (reprint author), 2351 E 22nd St, Cleveland, OH 44115 USA.
RI Sharp, Kath/A-4434-2012; Tyler, Dustin/C-7995-2015
OI Tyler, Dustin/0000-0002-2298-8510
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NR 23
TC 6
Z9 6
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD MAR
PY 2010
VL 119
IS 3
BP 141
EP 149
PG 9
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 580BH
UT WOS:000276421300001
PM 20392026
ER

PT J
AU Krishna, PD
   Statham, MM
   Rosen, CA
AF Krishna, Priya D.
   Statham, Melissa McCarty
   Rosen, Clark A.
TI Acute Glutaraldehyde Mucosal Injury of the Upper Aerodigestive Tract Due
   to Damage to the Working Channel of an Endoscope
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT 89th Annual Meeting of the American-Broncho-Esophagological-Association
CY MAY 28-29, 2009
CL Phoenix, AZ
SP Amer Broncho Esophagol Assoc
DE disinfection; flexible endoscopy; glutaraldehyde; mucosal injury
AB Objectives: Glutaraldehyde (Cidex) is a commonly used agent for cold sterilization of endoscopes despite its known irritative, allergic, and carcinogenic potential This report details the clinical course of 2 patients who suffered acute glutaraldehyde exposure during office injection procedures
   Methods: Clinical records of 2 outpatients undergoing office injection procedures were reviewed One patient underwent bilateral injections of hydroxyapatite, and 1 underwent voice gel injection
   Results: Both patients developed acute mucosal injury in the form of supraglottitis and laryngitis Both patients required inpatient admission with airway monitoring (1 requiring admission to the intensive care unit) and were treated with steroids and antibiotics The same channel endoscope was used for both procedures and was noted after careful examination to have retained glutaraldehyde inside the scope due to a perforation of the lining of the working channel
   Conclusions: Glutaraldehyde can cause acute mucosal injury to supraglottic and glottic structures, and diligent procedures must be maintained for Bushing the channels and monitoring glutaraldehyde retention in the channels Great care should be taken to avoid damage to the lining of working channels from instrumentation
C1 [Krishna, Priya D.; Statham, Melissa McCarty; Rosen, Clark A.] Univ Pittsburgh, Sch Med, Dept Otolaryngol, Div Laryngol, Pittsburgh, PA USA.
RP Krishna, PD (reprint author), UPMC Mercy, Suite 11500 D Ermire Bldg,1400 Locust St, Pittsburgh, PA 15219 USA.
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NR 16
TC 3
Z9 3
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD MAR
PY 2010
VL 119
IS 3
BP 150
EP 154
PG 5
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 580BH
UT WOS:000276421300002
PM 20392027
ER

PT J
AU MacNeil, SD
   Moxham, JP
AF MacNeil, S. Danielle
   Moxham, J. Paul
TI Review of Floor of Mouth Dysontogenic Cysts
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT Annual Meeting of the Western Section of the Triological-Society
CY JAN 29-31, 2009
CL Las Vegas, NV
SP Triol Soc, Western Sect
DE dermoid cyst; dysontogenic cyst; epidermoid cyst; floor of mouth;
   teratoid cyst
ID SUBLINGUAL DERMOID CYST; HETEROTOPIC GASTROINTESTINAL CYST; CONGENITAL
   TERATOID CYST; ORAL CAVITY; EPIDERMOID CYST; SINUS TRACT; NECK; INFANT;
   NEWBORN; HEAD
AB Objectives: We report the common surgical approaches. incidence of sinus tracts, and recurrence rates of floor of mouth dysontogenic (epidermoid, dermoid, and teratoid) cysts in the pediatric population
   Methods: Data were derived from PubMed, Mediate, Embase, Google Scholar, and manual searches Three cases from the senior author's (J PM) practice were included All English-language studies consisting of floor of mouth dysontogenic cysts were included Case reports of tongue dysontogenic cysts, mandibular dysontogenic cysts, maxillary dysontogenic cysts. and dysontogenic cysts in the neck below the hyoid bone were excluded
   Results: There are 198 case reports. including those presented here, of floor of mouth dysontogenic cysts They ale mole common in male patients (55 1%), and the most common location is in the sublingual space (104 or 52 5%) Most floor of mouth dysontogenic cysts can be excised by an intraoral approach Time are 5 repotted eases in the literature of recurrent dysontogenic cysts and II cases of multiple floor of mouth dysontogenic cysts
   Conclusions: Floor of mouth dysontogenic cysts most commonly present in the sublingual space. and most can be excised by an intraoral approach Multiple dysontogenic cysts often require a combination of intraoral and extraoral approaches Recurrence of a dysontogenic cyst may be secondary to a tract not identified the time of surgery
C1 [Moxham, J. Paul] Univ British Columbia, Pediat Otolaryngol Clin, British Columbia Childrens Hosp, Div Pediat Otolaryngol,Dept Surg, Vancouver, BC V6H 3V4, Canada.
RP Moxham, JP (reprint author), Univ British Columbia, Pediat Otolaryngol Clin, British Columbia Childrens Hosp, Div Pediat Otolaryngol,Dept Surg, 4480 Oak St, Vancouver, BC V6H 3V4, Canada.
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NR 73
TC 1
Z9 2
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD MAR
PY 2010
VL 119
IS 3
BP 165
EP 173
PG 9
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 580BH
UT WOS:000276421300004
PM 20392029
ER

PT J
AU Hopping, SB
   Joshi, AS
   Tanna, N
   Janjanin, S
AF Hopping, Steven B.
   Joshi, Arjun S.
   Tanna, Neil
   Janjanin, Sasa
TI Volumetric Facelift: Evaluation of Rhytidectomy With Alloplastic
   Augmentation
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE aging; alloplast; face; facelift; implant; rhytidectomy
ID SURGERY; COMPLICATIONS
AB Objectives: Facial aging occurs as a result of soft tissue atrophy and resorption of the bony skeleton which results in a loss of soft tissue volume and laxity of the overlying skin Volumetric augmentation is a key component of facial rejuvenation surgery, and should be considered of equal importance to soft tissue lining Augmentation can be accomplished with synthetic fillers. autologous grafts, soft tissue repositioning techniques, and/or alloplastic implants Only alloplastic implants. however, provide truly long-term volumetric correction To date. there have been no large series dealing with the complications and results of implantation performed concurrently with rhytidectomy. which we have termed-volumetric rhytidectomy We present our experience with 100 patients treated with a combination of malar and chin implants and rhytidectomy. compared to 200 patients who underwent rhytidectomy alone
   Methods: The authors performed a retrospective review of patients treated with a combination of silicone malar and chin augmentation with rhytidectomy versus patients treated with rhytidectomy alone Both groups of patients underwent close postoperative evaluation at 3 days. 1 week, 2 weeks, and 1 month All patients were surveyed at 6 months to assess aesthetic satisfaction Complication rates were noted and tabulated Statistical analysis was performed to evaluate for any differences in the two groups
   Results: Between 2002 and 2006, 100 patients underwent malar and chin implantation along with rhytidectomy, 200 patients underwent rhytidectomy alone In the first group, there were a total of 6 cases in which implant removal was necessary, and 2 cases m which revision was required There were no statistically significant differences (p<0 05) observed between the two groups with respect to major or minor hematoma, seroma, infection, sensory nerve injury, facial nerve injury. hypertrophic scarring. dehiscence. skin sloughing. or revision.
   Conclusions: Volumetric rhytidectomy reliably augments the malar and mental areas, allows for subtle skeletal contouring. and results in successful rejuvenation Rhytidectomy is relatively safe to perform concurrently with silicone augmentation. and does not result in an increased complication rate as compared to rhytidectomy alone
C1 [Hopping, Steven B.] George Washington Univ, Ctr Cosmet Surg, Washington, DC 20037 USA.
   [Hopping, Steven B.; Joshi, Arjun S.; Tanna, Neil] George Washington Univ, Div Otolaryngol Head & Neck Surg, Washington, DC 20037 USA.
   [Tanna, Neil] Univ Calif Los Angeles, Div Plast Surg, Los Angeles, CA USA.
   [Janjanin, Sasa] NIAMSD, NIH, Bethesda, MD 20892 USA.
RP Hopping, SB (reprint author), George Washington Univ, Ctr Cosmet Surg, 2440 M St NW,Suite 205, Washington, DC 20037 USA.
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NR 18
TC 6
Z9 6
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD MAR
PY 2010
VL 119
IS 3
BP 174
EP 180
PG 7
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 580BH
UT WOS:000276421300005
PM 20392030
ER

PT J
AU Marioni, G
   Staffieri, A
   Parisi, S
   Marchese-Ragona, R
   Zuccon, A
   Staffieri, C
   Sari, M
   Speranzoni, C
   de Filippis, C
   Rinaldi, R
AF Marioni, Gino
   Staffieri, Alberto
   Parisi, Saverio
   Marchese-Ragona, Rosario
   Zuccon, Andrea
   Staffieri, Claudia
   Sari, Marianna
   Speranzoni, Chiara
   de Filippis, Cosimo
   Rinaldi, Roberto
TI Rational Diagnostic and Therapeutic Management of Deep Neck Infections:
   Analysis of 233 Consecutive Cases
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE antibiotic; deep neck infections; diagnosis; surgical treatment
ID SPACE INFECTIONS; ABSCESS; CHALLENGE; ORIGIN; HEAD
AB Objectives: Although deep neck infections ale less common nowadays because of the widespread use of antibiotics. they continue to catty significant morbidity and mortality rates
   Methods: Between 2000 and 2008. deep neck infections were treated in 233 patients at the University of Padova Cases of peritonsillar abscess, superficial infections, infections due to external neck injuries, and in in head and neck tumors were excluded Clinical, radiologic, laboratory, and microbiological assessments were analyzed
   Results: The site of origin was identified in 189 of the 233 cases (81 1%), and the most common cause of deep neck infection was dental infection (39 5%) Intravenous antibiotic therapy was given to 78 patients. and 155 required both medical and surgical procedures The bacteria most of isolated were gram-positive anaerobic cocci None of our patients died of the deep neck infection or its complications
   Conclusions: It is worth emphasizing that airway support is the priority in patients with deep neck infections Empirical antibiotic treatments must cover gram-positive and gram-negative aerobic and anaerobic pathogens Surgical exploration and drainage may be mandatory in selected cases at presentation or in cases that fail to respond to parenteral antibiotics within the first 24 to 48 bouts It is important to perform cultures dui me operation to establish the pathogen(s) involved and to obtain an antibiogram to tailor the antibiotic treatment
C1 [Marioni, Gino; Staffieri, Alberto; Marchese-Ragona, Rosario; Staffieri, Claudia; Sari, Marianna; Speranzoni, Chiara; de Filippis, Cosimo] Univ Padua, Otolaryngol Sect, Dept Med & Surg Specialties, I-35128 Padua, Italy.
   [Zuccon, Andrea] Univ Padua, Castelfranco Veneto Hosp, Pediat Dent Div, I-35100 Padua, Italy.
   [Parisi, Saverio] Univ Padua, Dept Histol Microbiol & Med Biotechnol, I-35100 Padua, Italy.
   [Rinaldi, Roberto] Padova Gen Hosp, Infect & Trop Dis Div, Padua, Italy.
RP Marioni, G (reprint author), Univ Padua, Otolaryngol Sect, Dept Med & Surg Specialties, Via Giustiniani 2, I-35128 Padua, Italy.
RI parisi, saverio/D-3115-2012
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   Rega AJ, 2006, J ORAL MAXIL SURG, V64, P1377, DOI 10.1016/j.joms.2006.05.023
   Reynolds SC, 2007, INFECT DIS CLIN N AM, V21, P557, DOI 10.1016/j.idc.2007.03.002
   Smith JL, 2006, AM J OTOLARYNG, V27, P244, DOI 10.1016/j.amjoto.2005.11.008
   Stalfors J, 2004, ACTA OTO-LARYNGOL, V124, P1191, DOI 10.1080/00016480410017864
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   Yang SW, 2008, ORL J OTO-RHINO-LARY, V70, P249, DOI 10.1159/000132094
NR 18
TC 18
Z9 18
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD MAR
PY 2010
VL 119
IS 3
BP 181
EP 187
PG 7
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 580BH
UT WOS:000276421300006
PM 20392031
ER

PT J
AU Norris, BK
   Schweinfurth, JM
AF Norris, Byron K.
   Schweinfurth, John M.
TI Management of Recurrent Laryngeal Sensory Neuropathic Symptoms
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT 89th Annual Meeting of the American-Broncho-Esophagological-Association
CY MAY 28-29, 2009
CL Phoenix, AZ
SP Amer Broncho Esophagol Assoc
DE chronic cough; neuromodulator; sensory neuropathic symptom
ID CHRONIC COUGH; VAGAL NEUROPATHY; DIAGNOSIS
AB Objectives: We identity management strategies for the treatment of upper respiratory tract symptoms stemming from dysfunction of the recurrent laryngeal nerve
   Methods: We present a retrospective case series of patients who had symptoms of sensory neuropathy. including persistent dysphonia. laryngospasm. and chronic cough The patients were followed for symptomatic improvement after initiation of treatment with a neuromodulator Treatment outcome was defined by improvement or resolution of symptoms on a self-reported outcome scale
   Results: Of 12 patients identified, 75% exhibited evidence of motor neuropathy on laryngoscopy and 83% had symptoms related to chronic cough treated with neuromodulator therapy over a mean follow-up of 20 4 months The median dose of amitriptyline hydrochloride was 25 mg daily, and that of gabapentin was 300 mg 3 times daily The mean time from the initiation of therapy to a complete response was 2 months
   Conclusions: Patients with suspected neuropathy of the recurrent laryngeal nerve frequently respond to neuromodulator therapy The addition of reflux precautions and acid suppression therapy is helpful in cases of chronic and recurrent laryngospasm Patients with evidence of motor neuropathy appear to have better outcomes with neuromodulator therapy
C1 [Norris, Byron K.; Schweinfurth, John M.] Univ Mississippi, Dept Otolaryngol & Communicat Sci, Jackson, MS 39216 USA.
RP Norris, BK (reprint author), 2500 N State St, Jackson, MS 39216 USA.
CR Altman KW, 2002, OTOLARYNG HEAD NECK, V127, P501, DOI 10.1067/mhn.2002.127589
   Amin MR, 2001, AM J OTOLARYNG, V22, P251, DOI 10.1053/ajot.2001.24823
   Bastian RW, 2006, OTOLARYNG HEAD NECK, V135, P17, DOI 10.1016/j.otohns.2006.02.003
   FIENCH CL, 1998, ARCH INTERN MED, V158, P1657
   Irwin RS, 2000, NEW ENGL J MED, V343, P1715, DOI 10.1056/NEJM200012073432308
   Jeyakumar A, 2006, LARYNGOSCOPE, V116, P2108, DOI 10.1097/01.mlg.0000244377.60334.e3
   Lee B, 2005, ANN OTO RHINOL LARYN, V114, P253
   Morrison M, 1999, J VOICE, V13, P447, DOI 10.1016/S0892-1997(99)80049-6
NR 8
TC 7
Z9 7
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD MAR
PY 2010
VL 119
IS 3
BP 188
EP 191
PG 4
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 580BH
UT WOS:000276421300007
PM 20392032
ER

PT J
AU Oestreicher-Kedem, Y
   Agrawal, S
   Jackler, RK
   Damrose, EJ
AF Oestreicher-Kedem, Yael
   Agrawal, Sumit
   Jackler, Robert K.
   Damrose, Edward J.
TI Surgical Rehabilitation of Voice and Swallowing After Jugular Foramen
   Surgery
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE dysphagia; hoarseness; jugular tumor; rehabilitation; swallowing
ID SKULL BASE SURGERY; LOWER CRANIAL NERVES; CRICOPHARYNGEAL MYOTOMY;
   PHARYNGEAL PARALYSIS; ARYTENOID ADDUCTION; PALATAL ADHESION; MANAGEMENT;
   TUMORS; INJURY; COMPLICATIONS
AB Objectives: We sought to determine the patient population that will benefit from surgical rehabilitation of voice and swallowing after jugular foramen tumor (JFT) resection
   Methods: We performed a retrospective case study of patients with a history of JET resection The patients files were reviewed lot data on preoperative and postoperative function of cranial nerves VII and IX through XII, voice and swallowing function. and surgical procedures for voice and swallowing rehabilitation and thew timing.
   Results: Twenty-one patients underwent JFT resection Thirty-eight percent presented with deficits of cranial nerves VII and IX through XII, and 61% developed new postoperative deficits Three patients recovered glossopharyngeal nerve function. 2 recovered vagus nerve function, and I recovered facial nerve function Surgical rehabilitation procedures were undertaken in 8 patients Pat tents who eventually underwent surgical rehabilitation procedures for voice and swallowing tended to have larger tumors. tumors within the nerve bundle in the Jugular foramen and multiple nerve deficits
   Conclusions: Most patients with multiple deficits of cranial nerves VII and IX through XII after JFT resection are unlikely to regain spontaneous nerve function. will experience long-term dysphonia and dysphagia. and will elect to undergo corrective surgery to improve voice and swallowing Preoperative evaluation and close postoperative follow-up can identity patients who would benefit from early surgical rehabilitation
C1 [Oestreicher-Kedem, Yael; Agrawal, Sumit; Jackler, Robert K.; Damrose, Edward J.] Stanford Univ, Med Ctr, Dept Otolaryngol Head & Neck Surg, Stanford, CA 94305 USA.
RP Oestreicher-Kedem, Y (reprint author), 5 Gluskin St, IL-62157 Tel Aviv, Israel.
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   Pareschi R, 2003, SKULL BASE-INTERD AP, V13, P149
   Perie S, 1999, ANN OTO RHINOL LARYN, V108, P606
   Peterson KL, 2005, OTOLARYNG CLIN N AM, V38, P809, DOI 10.1016/j.otc.2005.01.008
   Ramina R, 2005, NEUROSURGERY, V57, P59, DOI 10.1227/01.NEU.0000163483.44754.47
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NR 20
TC 2
Z9 2
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD MAR
PY 2010
VL 119
IS 3
BP 192
EP 198
PG 7
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 580BH
UT WOS:000276421300008
PM 20392033
ER

PT J
AU Jacobson, JP
   Har-El, G
AF Jacobson, Joel P.
   Har-El, Gady
TI Trends in Scientific Interest of the American Broncho-Esophagological
   Association
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT 89th Annual Meeting of the American-Broncho-Esophagological-Association
CY MAY 28-29, 2009
CL Phoenix, AZ
SP Amer Broncho Esophagol Assoc
DE American Broncho-Esophagological Association; bronchoesophagology;
   trends
AB Objectives: The specialty of otolaryngology in the United States has changed dramatically over the past century. and this is particularly true in the field of bronchoesophagology, which has evolved from a new specialty at the beginning of the 20th century to one that is now multidisciplinary and further subspecialized The purpose of this report was to trace the evolution of bronchoesophagology over the past 60 years by examining and quantitating the scientific subject matter of the annual meetings of the American Broncho-Esophagological Association (ABEA)
   Methods: The Transact tons of the ABEA annual meetings from the 1940s to the present day were examined in depth for subject matter, and articles were categorized by topic Each decade was represented by 3 years Data were sorted into 3 domains 1) anatomic area. 2) adult versus pediatric. and 3) subject matter. including neoplasms. infectious diseases, foreign bodies, technologies, function, and trauma. The overall changes were quantified to outline the direction and interests of the ABEA
   Results: We reviewed 483 scientific articles from the 1940s into the present decade, with a mean of 69 7 papers (SD, 32 4) representing each decade Bronchology and pulmonology decreased in percentage of papers. from 43% and 17 9% in 1940 to 1 7% and 2 6%. respectively. in the 2000s Laryngology evolved from 12 5% to 58 1% Esophagology peaked in the 1950s at 35 7%, dropped to 4% in the 1980s, and then rose to its present-day level of 15 4% Trends were also discernible in gastric and tracheal areas Pediatric topics rose to 26 7% in the 1980s. then declined to their present level cif 12 8%. Topics related to aerodigestive tract function increased from 3 6% to 34.2%, and presentation of technology declined from 23 2% in the 1940s to nil in the 2000s Trends in neoplasms. infectious diseases. foreign bodies, and trauma were less significant
   Conclusions: Analysis of the data reveals changing trends in the focus of the ABEA The changing focus of the AREA has paralleled scientific advances in our field, as well as the use of other subspecialties such as interventional pulmonology and gastroenterology
C1 NYU, Lenox Hill Hosp, Dept Otolaryngol Head & Neck Surg, New York, NY 10016 USA.
   NYU, Langone Med Ctr, Dept Otolaryngol Head & Neck Surg, New York, NY 10016 USA.
RP Jacobson, JP (reprint author), NYU, Langone Med Ctr, Bellevue Hosp NBV 5E5, Dept Otolaryngol Head & Neck Surg, 550 1St Ave, New York, NY 10016 USA.
CR Andrus JG, 2005, LARYNGOSCOPE, V115, P993, DOI 10.1097/01.MLG.0000163756.89321.47
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NR 10
TC 0
Z9 0
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD MAR
PY 2010
VL 119
IS 3
BP 199
EP 202
PG 4
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 580BH
UT WOS:000276421300009
PM 20392034
ER

PT J
AU Samuels, TL
   Johnston, N
AF Samuels, Tina L.
   Johnston, Nikki
TI Pepsin as a Marker of Extraesophageal Reflux
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE biological marker; diagnostic test; extraesophageal reflux;
   laryngopharyngeal reflux; nonacidic reflux; pepsin
ID ANHYDRASE ISOENZYME-III; LARYNGOPHARYNGEAL REFLUX;
   GASTROESOPHAGEAL-REFLUX; OTITIS-MEDIA; GASTRIC CONTENTS; DISEASE; ASSAY;
   ACID; ASSOCIATION; SYMPTOMS
AB Diagnosis of extraesophageal reflux (EER) currently relies on tools designed for diagnosis of gastroesophageal reflux Such tools lack the sensitivity and reproducibility to detect the less frequent and mildly acidic reflux associated with upper airway disease Pepsin has been posited to be a reliable biological marker of EER. Our aim was to present a comprehensive literature review of the use of pepsin as a diagnostic marker of EER Two methods are typically used for detection of pepsin in the airways enzymatic and immunologic The limitations. advantages. and examples of use of each are discussed Pepsin assay has been used to identify refluxate in trachea, lung. sinus. middle eat. combined sputum and saliva. and breath condensate An immunologic pepsin assay of combined sputum and saliva was determined to be 100% sensitive and 89% specific for detection of EER (based on pH-metry). and an enzymatic test of nasal lavage fluid (100% sensitivity and 92 5% specificity) demonstrated an increased incidence of EER in patients with chronic rhinosinusitis Pepsin assay identified tracheal pepsin to be an indicator of bronchopulmonary dysplasia and related mortality risk in ventilated preterm infants Pepsin assay is a useful tool lot correlation of re flux with airway disease and is a reliable diagnostic marker of EER
C1 [Samuels, Tina L.; Johnston, Nikki] Med Coll Wisconsin, Dept Otolaryngol & Commun Sci, Milwaukee, WI 53226 USA.
RP Johnston, N (reprint author), Med Coll Wisconsin, Dept Otolaryngol & Commun Sci, 9200 W Wisconsin Ave, Milwaukee, WI 53226 USA.
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NR 34
TC 32
Z9 36
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD MAR
PY 2010
VL 119
IS 3
BP 203
EP 208
PG 6
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 580BH
UT WOS:000276421300010
PM 20392035
ER

PT J
AU Schindler, A
   Ginocchio, D
   Peri, A
   Felisati, G
   Ottaviani, F
AF Schindler, Antonio
   Ginocchio, Daniela
   Peri, Andrea
   Felisati, Giovanni
   Ottaviani, Francesco
TI FEESST in the Rehabilitation of Dysphagia After Partial Laryngectomy
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE dysphagia; laryngeal adductor reflex; rehabilitation; supracricoid
   laryngectomy; supraglottic laryngectomy
ID GLOTTIC CLOSURE REFLEX; PENETRATION-ASPIRATION SCALE; MODIFIED BARIUM
   SWALLOW; MOTOR CORTEX; SUPRACRICOID LARYNGECTOMY; ENDOSCOPIC EVALUATION;
   CENTRAL FACILITATION; BRAIN-INJURY; CANCER; RADIOTHERAPY
AB Objectives: We describe the role of the laryngeal adductor reflex (LAR) and fiberoptic endoscopic evaluation of swallowing with sensory testing (FEESST) in the rehabilitation of patients with oropharyngeal dysphagia after partial laryngectomy.
   Methods: Ten patients with a mean age of 64 years (range, 45 to 72 years) Were included in the study. Seven patients underwent supraglottic laryngectomy, and 3 had supracricoid laryngectomy. Six patients underwent additional radiotherapy (RT), and 8 had functional neck dissection (ND). FEESST was informed oil each patient in order to establish a swallowing rehabilitation program.
   Results: In 2 patients, not submitted to either ND or RT, the LAR was preserved in 6 patients, who underwent both procedures, the LAR was delayed or absent. In 2 patients who underwent ND but not RT, the LAR was preserved in 1 case and delayed in the other. The patients with all absent LAR presented severe aspiration. whereas in those with a preserved LAR, no penetration was found. Moderate aspiration was found in the remaining patients. In the patients with a reduced or absent LAR, tactile and chemical sensory stimulation was added to the rehabilitation program.
   Conclusions: FEESST represents a useful tool in everyday clinical practice for the planning of swallowing rehabilitation after partial laryngectomy.
C1 [Schindler, Antonio; Ginocchio, Daniela; Peri, Andrea; Ottaviani, Francesco] Univ Milan, Dept Clin Sci L Sacco, Milan, Italy.
   [Felisati, Giovanni] Univ Milan, Dept Specialist Surg Sci, Milan, Italy.
RP Schindler, A (reprint author), Osped L Sacco, Via GB Grassi 74, I-20157 Milan, Italy.
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NR 33
TC 4
Z9 4
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD FEB
PY 2010
VL 119
IS 2
BP 71
EP 76
PG 6
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 558BF
UT WOS:000274714400001
PM 20336915
ER

PT J
AU Vlantis, AC
   Bower, WF
   Woo, JKS
   Tong, MCF
   van Hasselt, CA
AF Vlantis, Alexander C.
   Bower, Wendy F.
   Woo, John K. S.
   Tong, Michael C. F.
   van Hasselt, C. Andrew
TI Endoscopic Assessment of the Nasopharynx: An Objective Score of
   Abnormality to Predict the Likelihood of Malignancy
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE biopsy; carcinoma; diagnosis; endoscopy; nasopharynx
ID CARCINOMA; BIOPSY
AB Objectives: We developed an objective endoscopic score of abnormality of the nasopharynx to predict the likelihood of malignancy.
   Methods: A score sheet with 44 variables was developed to objectively quantify the bilateral endoscopic assessment of the nasopharynx. Patients scheduled to Undergo nasopharyngeal biopsies were recruited. The nasopharynx was assessed endoscopically, photographed, and scored on 44 variables. The scores were compared to the biopsy results, and predictors of malignancy were modeled with regression analysis. The sensitivity and specificity of the novel scoring system were examined.
   Results: Seventeen patients had carcinoma, and 60 had a benign lesion or no disease. Patients with a nasopharyngeal malignancy scored significantly higher than did patients with a benign lesion or no disease. No patient with a malignant lesion had it score of less than 12. With a receiver operating characteristic curve area of 0.917, the score demonstrated an excellent ability to discriminate between nasopharynges that were likely or unlikely to contain malignant disease. Independent predictors for both malignant disease and a score greater than 12 were modeled.
   Conclusions: A cutoff score above 12 on the novel objective endoscopic assessment of the nasopharynx measure was highly predictive of possible malignancy.
C1 [Vlantis, Alexander C.; Woo, John K. S.; Tong, Michael C. F.; van Hasselt, C. Andrew] Chinese Univ Hong Kong, Prince Wales Hosp, Dept Otorhinolaryngol Head & Neck Surg, Shatin, Hong Kong, Peoples R China.
   [Bower, Wendy F.] Chinese Univ Hong Kong, Prince Wales Hosp, Dept Surg, Shatin, Hong Kong, Peoples R China.
RP Vlantis, AC (reprint author), Chinese Univ Hong Kong, Prince Wales Hosp, Dept Otorhinolaryngol Head & Neck Surg, Shatin, Hong Kong, Peoples R China.
RI Bower, Wendy/F-3119-2012
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NR 9
TC 1
Z9 1
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD FEB
PY 2010
VL 119
IS 2
BP 77
EP 81
PG 5
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 558BF
UT WOS:000274714400002
PM 20336916
ER

PT J
AU Cadoni, G
   Scorpecci, A
   Cianfrone, F
   Giannantonio, S
   Paludetti, G
   Lippa, S
AF Cadoni, Gabriella
   Scorpecci, Alessandro
   Cianfrone, Francesca
   Giannantonio, Sara
   Paludetti, Gaetano
   Lippa, Silvio
TI Serum Fatty Acids and Cardiovascular Risk Factors in Sudden
   Sensorineural Hearing Loss: A Case-Control Study
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE coenzyme Q; hypercholesterolemia; low-density lipoprotein; nervonic
   acid; sudden hearing loss
ID LOW-DENSITY-LIPOPROTEIN; LIPID-PEROXIDATION; UBIQUINOL-10; COENZYME-Q10;
   MECHANISMS; DISORDERS
AB Objectives: We analyzed the relationships between sudden sensorineural hearing loss (SSNHL) and serum levels of fatty acids. total cholesterol, low-density lipoproteins (LDLs), and the antioxidant coenzyme Q10.
   Methods: Forty-three patients with SSNHL and 43 healthy subjects were enrolled in the study. The main outcome measures were serum levels of fatty acids, coenzyme Q10, total cholesterol, and LDLs.
   Results: On univariate logistic regression analysis. high levels of total cholesterol (p < 0.001), LDLs (p = 0.024), behenic acid (p < 0.001), docosahexaenoic acid (p < 0.001). linolenic acid (p = 0.017) and oleic acid (p < 0.001) and low levels of coenzyme Q10 (p < 0.001) and nervonic acid (p < 0.001) were associated with all elevated risk of SSNHL. Oil Multivariate analysis. Only hypercholesterolemia (p = 0.15) and low levels of coenzyme Q10 (p = 0.02) and nervonic acid (p = 0.005) were significantly associated with SSNHL.
   Conclusions: This is the first report of low serum levels of nervonic acid as an independent risk factor for SSNHL. Considering that hypercholesterolemia, high serum levels of LDL, and low serum levels of the antioxidant coenzyme Q10 were associated with SSNHL as well. we hypothesize that saturated fatty acids may play a role in determining the dysmetabolic state in a subset of SSNHL patients. Together. these findings suggest that not only total cholesterol and LDL levels. but also fatty acid determination, may help identify SSNHL patients with cardiovascular risk factors.
C1 [Cadoni, Gabriella; Scorpecci, Alessandro; Cianfrone, Francesca; Giannantonio, Sara; Paludetti, Gaetano] Univ Cattolica Sacro Cuore, Inst Otohinolaryngol, I-00168 Rome, Italy.
   [Lippa, Silvio] Univ Cattolica Sacro Cuore, Dept Biochem, I-00168 Rome, Italy.
RP Cadoni, G (reprint author), Univ Cattolica Sacro Cuore, Inst Otohinolaryngol, Largo A,Gemelli 8, I-00168 Rome, Italy.
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   Takemoto Y, 2003, BRAIN DEV-JPN, V25, P481, DOI 10.1016/S0387-7604(03)00033-0
   ULLRICH D, 1992, EUR ARCH OTO-RHINO-L, V249, P273, DOI 10.1007/BF00714491
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NR 21
TC 8
Z9 8
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD FEB
PY 2010
VL 119
IS 2
BP 82
EP 88
PG 7
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 558BF
UT WOS:000274714400003
PM 20336917
ER

PT J
AU Laccourreye, O
   Mirghani, H
   Brasnu, D
   Badoual, C
AF Laccourreye, Ollivier
   Mirghani, Haitham
   Brasnu, Daniel
   Badoual, Cecile
TI Imported Acute and Isolated Glottic Paracoccidioidomycosis
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE larynx; mycosis
ID SOUTH-AMERICAN BLASTOMYCOSIS; MANIFESTATIONS; CARCINOMA; DIAGNOSIS;
   LARYNX
AB The current report documents the rare clinical presentation of an imported acute and isolated glottic paracoccidioidomycosis. We discuss the diagnosis, pathogenesis, and treatment of this laryngeal disease, emphasizing the role of modern antifungal treatment, and review the relevant literature.
C1 [Laccourreye, Ollivier; Mirghani, Haitham; Brasnu, Daniel] Univ Paris 05, Dept Otorhinolaryngol Head & Neck Surg, HEGP, AP HP, F-75015 Paris, France.
   [Badoual, Cecile] Univ Paris 05, Dept Pathol, HEGP, AP HP, F-75015 Paris, France.
RP Laccourreye, O (reprint author), Univ Paris 05, Dept Otorhinolaryngol Head & Neck Surg, HEGP, AP HP, 20-40 Rue Leblanc, F-75015 Paris, France.
CR Ajello L, 1985, Eur J Epidemiol, V1, P160
   AJELLO L, 1986, EUR J EPIDEMIOL, V2, P81
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NR 14
TC 1
Z9 1
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD FEB
PY 2010
VL 119
IS 2
BP 89
EP 92
PG 4
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 558BF
UT WOS:000274714400004
PM 20336918
ER

PT J
AU Bhandarkar, ND
   Sims, HS
   David, O
AF Bhandarkar, Naveen D.
   Sims, H. Steven
   David, Odile
TI ProEx C Stain Analysis in Recurrent Respiratory Papillomatosis
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT 89th Annual Meeting of the American-Broncho-Esophagological-Association
CY MAY 28-29, 2009
CL Phoenix, AZ
SP Amer Broncho Esophagol Assoc
DE dysplasia; human papillomavirus; larynx; ProEx C; recurrent respiratory
   papillomatosis
ID CERVICAL CYTOLOGY; RISK-FACTORS; EXPRESSION; LESIONS; TRANSFORMATION;
   CARCINOMA; P53; DNA
AB Objectives: We evaluated the presence and pattern of ProEx C Stain, a marker for the proliferative capacity of cells. in laryngeal tissues, including benign, malignant, and recurrent respiratory papilloma (RRP) specimens. and compared it to hematoxylin and eosin staining for the presence of dysplasia.
   Methods: We performed a retrospective study with chart review.
   Results: A total of 26 specimens (9 benign, 7 malignant, 10 RRP) representing 21 patients were stained. ProEx C stained positive in the nuclei of laryngeal tissue, consistent with its localization in cervical cytology specimens. Seven of 9 benign and 7 of 10 RRP specimens stained positive. The benign specimens were mostly polyps. The malignant specimens Were either well or moderately differentiated squamous cell carcinoma, and they stained strongly and diffusely. In benign and RRP specimens. the basal layer typically stained positive. Other areas of epithelium stained weakly in benign specimens and variably in RRP specimens. current analysis of hematoxylin and eosin-stained RRP specimens revealed that 30% of specimens had at least moderate dysplasia and 80% exhibited viral changes (koilocytosis).
   Conclusions: ProEx C is a clean and reliable stain in laryngeal tissue, and stains positive in RRP. This study could not definitively correlate positive ProEx C staining in areas of greater dysplasia, although a trend was observed. Further studies are necessary to determine whether ProEx C can be used in triage of cases of clinically aggressive RRP For closer follow-up or frequent operative intervention.
C1 [Bhandarkar, Naveen D.; Sims, H. Steven] Univ Illinois, Dept Otolaryngol Head & Neck Surg, Chicago, IL USA.
   [David, Odile] Univ Illinois, Dept Pathol, Chicago, IL USA.
   [Sims, H. Steven] Univ Illinois, Chicago Inst Voice Care, Chicago, IL USA.
RP Sims, HS (reprint author), 1855 W Taylor St,Room 2-42, Chicago, IL 60612 USA.
CR Altieri Dario C, 2003, Prog Cell Cycle Res, V5, P447
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NR 18
TC 2
Z9 2
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD FEB
PY 2010
VL 119
IS 2
BP 99
EP 104
PG 6
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 558BF
UT WOS:000274714400006
PM 20336920
ER

PT J
AU Remacle, M
   Matar, N
   Verduyckt, I
   Lawson, G
AF Remacle, Marc
   Matar, Nayla
   Verduyckt, Ingrid
   Lawson, Georges
TI Relaxation Thyroplasty for Mutational Falsetto Treatment
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT 89th Annual Meeting of the American-Broncho-Esophagological-Association
CY MAY 28-29, 2009
CL Phoenix, AZ
SP Amer Broncho Esophagol Assoc
DE Isshiki type III thyroplasty; mutational falsetto; relaxation
   thyroplasty
ID LARYNGEAL FRAMEWORK SURGERY; III THYROPLASTY; VOICE DISORDERS;
   LARYNGOPLASTY; MANAGEMENT; DYSPHONIA; OUTCOMES
AB Mutational falsetto voice is considered to be a psychogenic disorder associated with the rejection of adulthood. The initial treatment must include speech therapy and psychotherapy. However, delayed treatment and denial of the problem can cause the disorder to become recalcitrant to behavioral treatment. Modified relaxation (type III) thyroplasty was proposed by Isshiki to shorten the vocal folds and release tension by incising and depressing the anterior segment of the thyroid cartilage. This procedure is called relaxation thyroplasty by a medial approach (anterior commissure retrusion) in the European Laryngological Society classification system. It results in a lowering of the vocal pitch. The surgery can be performed under local or general anesthesia. It should only be considered for cases not improved by speech therapy and psychological counseling. Our series included 7 male patients with a mean age of 21 years Who Underwent modified relaxation thyroplasty after failure of behavioral management. The assessment of outcomes was based on changes in the fundamental frequency of the voice and the Voice Handicap Index. The mean fundamental frequency was lowered from 187 Hz to 104 Hz (p < 0.001), and the mean Voice Handicap Index was improved from 70 to 21. There were no postoperative Complications. The voice results were consistent over a mean follow-up of 17 months. Modified relaxation Isshiki (type III) thyroplasty is a successful treatment option for lowering vocal pitch in cases Of mutational falsetto voice recalcitrant to conservative therapy.
C1 [Remacle, Marc; Matar, Nayla; Verduyckt, Ingrid; Lawson, Georges] Louvain Univ Hosp Mt Godinne, Dept Otorhinolaryngol Head & Neck Surg, B-5530 Yvoir, Belgium.
RP Remacle, M (reprint author), Louvain Univ Hosp Mt Godinne, Dept Otorhinolaryngol Head & Neck Surg, Therasse Ave 1, B-5530 Yvoir, Belgium.
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NR 19
TC 2
Z9 2
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD FEB
PY 2010
VL 119
IS 2
BP 105
EP 109
PG 5
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 558BF
UT WOS:000274714400007
PM 20336921
ER

PT J
AU Yamashita, M
   Kanemaru, S
   Hirano, S
   Umeda, H
   Kitani, Y
   Omori, K
   Nakamura, T
   Ito, J
AF Yamashita, Masaru
   Kanemaru, Shin-ichi
   Hirano, Shigeru
   Umeda, Hiroo
   Kitani, Yoshiharu
   Omori, Koichi
   Nakamura, Tatsuo
   Ito, Juichi
TI Glottal Reconstruction With a Tissue Engineering Technique Using
   Polypropylene Mesh: A Canine Experiment
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE fascia; laryngeal defect; polypropylene; reconstruction; tissue
   engineering; tissue regeneration
ID VERTICAL PARTIAL LARYNGECTOMY; LARYNGOTRACHEAL RECONSTRUCTION; FLAP
   RECONSTRUCTION; THYROID-GLAND; LARYNX; TRACHEA; REGENERATION;
   HEMILARYNGECTOMY; FASCIA; MODEL
AB Objectives: The larynx must be resected in some cases of cancer or stenosis, and various techniques are generally employed to fill the resulting defect. No ideal way, however, has been established to restore vocal function after this form of insult. The aim of this preliminary feasibility study in a canine model was to investigate the effectiveness of a polypropylene-based tissue engineering approach to repair a partial glottal defect.
   Methods: Eight dogs were used in this study, A laryngeal defect involving resection of the left vocal fold was created through a thyroid cartilage window. A scaffold made of polypropylene and collagen was preclotted and wrapped with autologous fascia lata, inserted through the window, and sutured to the laryngeal defect in 5 dogs. The defect was reconstructed with an adjacent sternohyoid muscle flap in 3 control dogs. The surgical site was evaluated 3 months after operation by fiberscopic examination, computed tomographic imaging, histologic evaluation,a and study of excised larynges.
   Results: On fiberscopic examination, the experimental group implants were completely covered with regenerated mucosa in all case, and a favorable vocal fold contour was found in 4 of the 5 cases. One case was characterized by a concave vocal fold shape and red granulation. In the control group, the muscle flap was replaced by scarred mucosa with a concave vocal fold contour in 2 cases, and there was soft white granulation at the anterior resected edge in the third case. The histologic data revealed the regeneration of lined epithelium, subepithelial tissue, and muscle structure in both groups. The excised larynx phonatory data revealed reduced vibratory amplitude in the experimental group compared with the control group; however, excised phonation was not achieved in 2 of the 3 cases in the control group.
   Conclusions: This polypropylene-based tissue engineering technique appears to be a viable tool for glottal reconstruction; however, additional refinement is required to maximize long-term phonatory function.
C1 [Yamashita, Masaru; Kanemaru, Shin-ichi; Hirano, Shigeru; Umeda, Hiroo; Kitani, Yoshiharu; Ito, Juichi] Kyoto Univ, Grad Sch Med, Dept Otolaryngol Head & Neck Surg, Sakyo Ku, Kyoto 6068507, Japan.
   [Nakamura, Tatsuo] Kyoto Univ, Inst Frontier Med Sci, Dept Bioartificial Organs, Kyoto 6068507, Japan.
   [Omori, Koichi] Fukushima Med Univ, Dept Otolaryngol, Fukushima, Japan.
RP Kanemaru, S (reprint author), Kyoto Univ, Grad Sch Med, Dept Otolaryngol Head & Neck Surg, Sakyo Ku, 54 Kawahara Cho, Kyoto 6068507, Japan.
RI Yamashita, Masaru/B-2411-2009
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NR 33
TC 2
Z9 2
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD FEB
PY 2010
VL 119
IS 2
BP 110
EP 117
PG 8
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 558BF
UT WOS:000274714400008
PM 20336922
ER

PT J
AU Liu, CB
   Wu, CJ
   Wang, FJ
   Zhou, M
AF Liu, Chunbo
   Wu, Changjun
   Wang, Fengjun
   Zhou, Min
TI Mutations of GNAS and TSHR Genes in Subclinical Toxic Multinodular
   Goiter
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE GNAS gene; mutation; subclinical toxic multinodular goiter; TSHR gene
ID THYROTROPIN RECEPTOR; THYROID-NODULES; HYPERTHYROIDISM; THYROTOXICOSIS;
   PREVALENCE; INCREASE
AB Objectives: This study aimed to detect the mutations of the GNAS and TSHR genes in subclinical toxic multinodular go iter (sTMG) and to evaluate the relationship between these Mutations and sTMG.
   Methods: Forty-four patients with sTMG and 20 matched controls (multinodular goiter) were recruited into this study. All of the patients underwent subtotal thyroidectomy. Gene mutations were analyzed by direct DNA sequencing of the polymerase chain reaction-amplified part of exons.
   Results: In the sTMG group, 3 mutations of the GNAS gene were identified in 7 patients (15.9%), and 6 mutations of the TSHR gene were identified in 14 patients (31.8%). The mutation rate of the TSHR gene in patients with sTMG was significantly higher than that in the control group. Furthermore, in the sTMG group, statistical analysis indicated that mutations were significantly correlated with the serum level of thyroid-stimulating hormone for the TSHR gene, but no significant difference was found for the GNAS gene. Also, no significant difference was found in mutation positivity of the 2 genes between patients with nodules who were born before universal salt iodization and patients with nodules who were born afterward (p > 0.05).
   Conclusions: The results indicate that a mutation of the TSHR gene may be related to sTMG. The serum thyroid-stimulating hormone level plays an important role in the mutagenesis.
C1 [Liu, Chunbo; Wu, Changjun] Harbin Med Coll, Affiliated Hosp 1, Dept Ultrasound, Harbin, Heilongjiang, Peoples R China.
   [Wang, Fengjun] Harbin Med Coll, Affiliated Hosp 1, Dept Surg, Harbin, Heilongjiang, Peoples R China.
   [Zhou, Min] Harbin Med Coll, Affiliated Hosp 1, Dept Pathol, Harbin, Heilongjiang, Peoples R China.
RP Wu, CJ (reprint author), Harbin Med Coll, Affiliated Hosp 1, Dept Ultrasound, Harbin, Heilongjiang, Peoples R China.
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NR 19
TC 1
Z9 1
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD FEB
PY 2010
VL 119
IS 2
BP 118
EP 124
PG 7
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 558BF
UT WOS:000274714400009
PM 20336923
ER

PT J
AU Witt, RE
   Hoffman, MR
   Friedrich, G
   Rieves, AL
   Schoepke, BJ
   Jiang, JJ
AF Witt, Rachel E.
   Hoffman, Matthew R.
   Friedrich, Gerhard
   Rieves, Adam L.
   Schoepke, Benjamin J.
   Jiang, Jack J.
TI Multiparameter Analysis of Titanium Vocal Fold Medializing Implant in an
   Excised Larynx Model
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE laryngeal framework surgery; titanium vocal fold medializing implant;
   unilateral vocal fold paralysis
ID THYROPLASTY TYPE-I; VIVO CANINE MODEL; ARYTENOID ADDUCTION; CORD
   MEDIALIZATION; VOICE QUALITY; LARYNGOPLASTY; INJECTION; TEFLON;
   BIOMECHANICS; PARALYSIS
AB Objectives: We evaluated the efficacy of the titanium vocal fold medializing implant (TVFMI) for the treatment of unilateral vocal fold paralysis (UVFP) on the basis of acoustic , aerodynamic, and mucosal wave measurements in and excised larynx setup.
   Methods: Measurements were recorded on 8 excised canine larynges with simulated UVFP before and after medialization with a TVFMI.
   Results: The phonation threshold flow (p < 0.001) and phonation threshold power (p = 0.008) decreased significantly after medialization. The phonation threshold pressure also decreased, but this difference was not significant (p = 0.081). Jitter (p = 0.005) and shimmer (p = 0.034) decreased significantly after medialization. The signal-to-noise ratio increased significantly (p = 0.05). Differences in mucosal wave characteristics were discernible but not significant. The phase difference between the normal and paralyzed vocal folds (p = 0.15) and the amplitude of the paralyzed vocal fold (p = 0.78) decreased. The glottal gap decreased significantly (p = 0.004).
   Conclusions: The TVFMI was effective in achieving vocal fold medialization, improving vocal aerodynamic and acoustic characteristics of phonation significantly and mucosal wave characteristics discernibly. This study provides objective, quantitative support for the use of the TVFMI in improving vocal function in patients with UVFP.
C1 [Witt, Rachel E.; Hoffman, Matthew R.; Rieves, Adam L.; Schoepke, Benjamin J.; Jiang, Jack J.] Univ Wisconsin, Sch Med & Publ Hlth, Dept Surg, Div Otolaryngol Head & Neck Surg, Madison, WI USA.
   [Friedrich, Gerhard] Med Univ Graz, Dept Phoniatr Speech & Swallowing, Ear Nose & Throat Univ Hosp, Graz, Austria.
RP Jiang, JJ (reprint author), 1300 Univ AVe,5745 Med Sci Ctr, Madison, WI 53706 USA.
CR Bless D M, 1987, Ear Nose Throat J, V66, P289
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NR 38
TC 2
Z9 2
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD FEB
PY 2010
VL 119
IS 2
BP 125
EP 132
PG 8
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 558BF
UT WOS:000274714400010
PM 20336924
ER

PT J
AU Campagnolo, AM
   Tsuji, DH
   Sennes, LU
   Imamura, R
   Saldiva, PHN
AF Campagnolo, Andrea M.
   Tsuji, Domingos Hiroshi
   Sennes, Luiz Ubirajara
   Imamura, Rui
   Saldiva, Paulo H. N.
TI Histologic Study of Acute Vocal Fold Wound Healing After Corticosteroid
   Injection in a Rabbit Model
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE collagen; inflammatory reaction; injectable corticosteroid; vocal fold
   scar
ID MICROFLAP; LARYNX
AB Objectives: Injectable corticosteroids have been used in phonosurgery to prevent scarring of the vocal fold because of their effects of wound healing, and to ensure better voice quality. We histologically evaluated the effects of dexamethasone sodium phosphate infiltration on acute vocal fold wound healing in rabbits 3 and 7 days after surgically induced injury by quantification of the inflammatory reaction and collagen deposition.
   Methods: A standardized surgical incision was made in the vocal folds of 12 rabbits, and 0.1 mL dexamethasone sodium phosphate (4 mg/mL) was injected into the left vocal fold. The right vocal fold was not injected and served as the control. The larynges were collected 3 and 7 days after surgery. For histologic analysis, the vocal folds were stained with hematoxylin-eosin for quantification of the inflammatory response and with picrosirius red for qunatification of collagen depostion.
   Results: There was no quantitative difference in the inflammatory response between vocal folds injected with the corticosteroid and control vocal folds. However, the rate of collage deposition was significantly lower in the corticosteroid-treated group at 3 and 7 days after injury (p = 0.002).
   Conclusions: The present results suggest that dexamethasone reduces collagen depostion during acute vocal fold wound healing.
C1 [Campagnolo, Andrea M.; Tsuji, Domingos Hiroshi; Sennes, Luiz Ubirajara; Imamura, Rui] Univ Sao Paulo, Sch Med, Dept Otolaryngol, Sao Paulo, Brazil.
   [Saldiva, Paulo H. N.] Univ Sao Paulo, Sch Med, Dept Pathol, Sao Paulo, Brazil.
RP Campagnolo, AM (reprint author), R Alceu Amoroso Lima 105-1802, BR-22631010 Rio De Janeiro, Brazil.
RI Saldiva, Paulo/D-7385-2012; Sennes, Luiz/E-6815-2012
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NR 28
TC 14
Z9 14
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD FEB
PY 2010
VL 119
IS 2
BP 133
EP 139
PG 7
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 558BF
UT WOS:000274714400011
PM 20336925
ER

PT J
AU Mehta, DD
   Deliyski, DD
   Zeitels, SM
   Quatieri, TF
   Hillman, RE
AF Mehta, Daryush D.
   Deliyski, Dimitar D.
   Zeitels, Steven M.
   Quatieri, Thomas F.
   Hillman, Robert E.
TI Voice Production Mechanisms Following Phonosurgical Treatment of Early
   Glottic Cancer
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT 89th Annual Meeting of the American-Broncho-Esophagological-Association
CY MAY 28-29, 2009
CL Phoenix, AZ
SP Amer Broncho Esophagol Assoc
DE acoustic perturbation; glottic cancer; high-speed videoendoscopy; vocal
   fold asymmetry; voice production
ID HIGH-SPEED VIDEOENDOSCOPY; VOCAL FOLD; VIDEOKYMOGRAPHY; EVOLUTION
AB Objectives: Although near-normal conversational voices can be achieved with the phonosurgical management of early glottic cancer, there are still acoustic and aerodynamic deficits in vocal function that Must be better understood to help further optimize phonosurgical interventions. Stroboscopic assessment is inadequate for this purpose.
   Methods: A newly developed color high-speed videoendoscopy (HSV) system that included time-synchronized recordings of the acoustic signal Was used to perform a detailed examination of voice production mechanisms in 14 Subjects. Digital image processing techniques were used to quantify glottal phonatory function and to delineate relationships between vocal fold vibratory properties and acoustic perturbation measures.
   Results: The results for multiple measurements of vibratory asymmetry showed that 31% to 62% of subjects displayed higher-than-normal average values, whereas the mean values for glottal Closure duration (open quotient) and periodicity of vibration fell within normal limits. The average HSV-based measures did not correlate significantly with the acoustic perturbation Measures, but moderate correlations were exhibited between the acoustic measures and the SDs of the HSV-based parameters.
   Conclusions: The use of simultaneous, time-synchronized HSV and acoustic recordings can provide new insights into postoperative voice production mechanisms that cannot be obtained with stroboscopic assessment.
C1 [Mehta, Daryush D.; Zeitels, Steven M.; Hillman, Robert E.] Massachusetts Gen Hosp, Ctr Laryngeal Surg & Voice Rehabil, Boston, MA 02114 USA.
   [Mehta, Daryush D.; Quatieri, Thomas F.; Hillman, Robert E.] MIT, Harvard Mit Div Hlth Sci & Technol, Speech & Hearing Biosci & Technol Program, Cambridge, MA 02139 USA.
   [Mehta, Daryush D.; Quatieri, Thomas F.] MIT, Lincoln Lab, Lexington, MA 02173 USA.
   [Zeitels, Steven M.; Hillman, Robert E.] Harvard Univ, Sch Med, Dept Surg, Boston, MA 02115 USA.
   [Deliyski, Dimitar D.] Univ S Carolina, Dept Commun Sci & Disorders, Columbia, SC 29208 USA.
RP Hillman, RE (reprint author), Massachusetts Gen Hosp, Ctr Laryngeal Surg & Voice Rehabil, 1 Bowdoin Sq,11th Floor, Boston, MA 02114 USA.
CR Bonilha HS, 2008, AM J SPEECH-LANG PAT, V17, P367, DOI 10.1044/1058-0360(2008/07-0059)
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   Qiu QJ, 2003, FOLIA PHONIATR LOGO, V55, P128, DOI 10.1159/000070724
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   Titze I. R, 1995, WORKSH AC VOIC AN SU, P1
   Zeitels SM, 1996, AM J SURG, V172, P704, DOI 10.1016/S0002-9610(96)00295-4
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NR 20
TC 31
Z9 32
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD JAN 10
PY 2010
VL 119
IS 1
BP 1
EP 9
PG 9
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 544SW
UT WOS:000273680600001
PM 20128179
ER

PT J
AU Webster, KT
   Samlan, RA
   Jones, B
   Bunton, K
   Tufano, RP
AF Webster, Kimberly T.
   Samlan, Robin A.
   Jones, Bronwyn
   Bunton, Kate
   Tufano, Ralph P.
TI Supracricoid Partial Laryngectomy: Swallowing, Voice, and Speech
   Outcomes
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE functional outcome; supracricoid laryngectomy; swallowing; voice
ID CRICOHYOIDOEPIGLOTTOPEXY; CRICOHYOIDOPEXY; PRESERVATION; DEGLUTITION;
   CARCINOMA
AB Objectives: The purpose of the study was to describe the swallowing and vocal function of patients after supracricoid partial laryngectomy (SCPL) as they changed over the first postoperative year.
   Methods: Ten patients with laryngeal carcinoma underwent SCPL at Johns Hopkins Hospital between August 2003 and May 2005. Clinical and videofluoroscopic swallowing examinations and perceptual, acoustic, aerodynamic, and video-stroboscopic voice evaluations were completed before operation and at 3 weeks (swallowing only) and 2 (voice only), 6, and 12 months after operation.
   Results: The mean time to gastrostomy tube removal was 82 days. The patients tolerated an increased variety of foods over the first postoperative year. All patients initially used therapeutic strategies to swallow safely, and some still required them at 1 postoperative year. Over the year, the perceptual ratings of voice quality improved significantly. There were no consistent changes in acoustic or aerodynamic measures. The number of patients who used multiple vibratory sources to phonate increased over the year.
   Conclusions: The patients tolerated regular diets, yet continued to exhibit silent aspiration and a variety of decompensations. Their voices were breathy, rough, and strained. Their voice quality ratings improved over the year. Group changes were not captured, and it appears that the changes in speech and voice 2 months after surgery were subtle.
C1 [Webster, Kimberly T.; Samlan, Robin A.; Tufano, Ralph P.] Johns Hopkins Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, Baltimore, MD 21205 USA.
   [Jones, Bronwyn] Johns Hopkins Univ Hosp, Russell H Morgan Dept Radiol & Radiol Sci, Baltimore, MD 21287 USA.
   [Bunton, Kate] Univ Arizona, Dept Speech Language & Hearing Sci, Tucson, AZ USA.
RP Webster, KT (reprint author), Johns Hopkins Outpatient Ctr, 601 N Caroline St,Room 6265, Baltimore, MD 21287 USA.
FU Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
   [M020-536-0104]
FX From the Department of Otolaryngology-Head and Neck Surgery, Johns
   Hopkins University School of Medicine (Webster, Samlan, Tufano), and the
   Russell H. Morgan Department of Radiology and Radiological Sciences,
   Johns Hopkins Hospital (Jones), Baltimore, Maryland, and the Department
   of Speech, Language, and Hearing Science, University of Arizona, Tucson,
   Arizona (Bunton). This work was supported by Clinical Grant
   M020-536-0104 from the Sidney Kimmel Comprehensive Cancer Center at
   Johns Hopkins.
CR *AM SPEECH LANG HE, 2003, SPEC INT DIV 3 VOIC
   BOERSNIA P, PRAAT DOING PHONETIC
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NR 22
TC 7
Z9 8
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD JAN 10
PY 2010
VL 119
IS 1
BP 10
EP 16
PG 7
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 544SW
UT WOS:000273680600002
PM 20128180
ER

PT J
AU Rawlings, BA
   Han, JK
AF Rawlings, Brad A.
   Han, Joseph K.
TI Level of Complete Dissection of the Ethmoid Sinuses With a Computed
   Tomographic Image Guidance System
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE endoscopic sinus surgery; ethmoid sinus; ethmoidectomy; image guidance
   surgery; intratoperative computed tomographic scanner; skull base
   surgery
ID RESIDENCY TRAINING-PROGRAM; SKULL BASE SURGERY; COMPLICATIONS; CADAVER;
   UTILITY; UPDATE
AB Objectives: We Sought to determine the adequacy of endoscopic total ethmoidectomy with the use of a computed tomographic (CT) image guidance system.
   Methods: Endoscopic ethmoid sinus dissections were performed on cadavers by otolaryngologists. All cadavers were scanned before dissection. On each side of the cadaver, the ethmoid sinuses were examined independently. A complete endoscopic ethmoidectomy was performed with a CT image guidance system. After the endoscopic ethmoidectomy, the cadaver underwent a postdissection CT scan. The postdissection CT images were then evaluated for the level of complete dissection of the anterior and posterior ethmoid Sinuses.
   Results: There were 18 ethmoid Sinuses in the Study. One specimen underwent a complete total ethmoidectomy with no residual cells. There were 4 complete anterior ethmoidectomies and 5 complete posterior ethmoidectomies. Overall, the average numbers of residual anterior ethmoid and posterior ethmoid air cells were 1.39 and 1.22, respectively. This difference was not statistically significant. The skull base was dissected more completely than the lamina papyracea, with a significant difference (p = 0.03). There was no difference in terms of residual cells between the left and right ethmoid sinuses (p > 0.05).
   Conclusions: Even with the use of a CT image guidance system, a complete ethmoidectomy was still difficult to achieve. Residual ethmoid sinus cells were more commonly found along the lamina papyracea than along the skull base.
C1 [Rawlings, Brad A.; Han, Joseph K.] Eastern Virginia Med Sch, Dept Otolaryngol Head & Neck Surg, Norfolk, VA 23507 USA.
RP Han, JK (reprint author), Eastern Virginia Med Sch, Dept Otolaryngol Head & Neck Surg, 600 Gresham Dr,Suite 1100, Norfolk, VA 23507 USA.
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NR 16
TC 2
Z9 2
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD JAN 10
PY 2010
VL 119
IS 1
BP 17
EP 21
PG 5
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 544SW
UT WOS:000273680600003
PM 20128181
ER

PT J
AU Suzuki, K
   Inokuchi, A
   Miyazaki, J
   Kuratomi, Y
   Izuhara, K
AF Suzuki, Kumiko
   Inokuchi, Akira
   Miyazaki, Junji
   Kuratomi, Yuichiro
   Izuhara, Kenji
TI Relationship Between Squamous Cell Carcinoma Antigen and the Clinical
   Severity of Allergic Rhinitis Caused by Dermatophagoides farinae and
   Japanese Cedar Pollen
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE house dust mite; perennial allergic rhinitis; pollen; seasonal allergic
   rhinitis; severity; squamous cell carcinoma antigen
ID ASTHMA; SYMPTOMS; CHILDREN
AB Objectives: Allergic rhinitis is known to be related to the Th2-type immune response, but no sensitive biomarker of severity yet exists. Serum squamous cell carcinoma antigen (SCCA) is clinically used as a popular tumor biomarker. We have demonstrated that SCCA is related to allergic diseases such as asthma. The purpose of the present study was to clarify the relationship between allergic rhinitis and SCCA, which had not yet been investigated.
   Methods: We compared the serum SCCA levels in patients with allergic rhinitis due to Japanese cedar pollen and Dermatophagoides farinae with those in normal Subjects. Thereafter, the correlations between the clinical severity of allergic rhinitis and the serum levels of SCCA were investigated. Furthermore, the influence of 8 variables (serum levels of SCCA, immunoglobulin E, eosinophil cationic protein, and eosinophils; age; gender; oral administration of antiallergic or antihistaminic agents; and use of nasal drops) in regard to the severity of allergic rhinitis was studied by a multiple regression analysis.
   Results: The SCCA levels of the D farinae group were statistically higher than those of the control group, and they correlated with the severity of rhinitis. Among the 8 variables, only the SCCA level was found to be a predictive factor of severity on a multiple regression analysis. No relationship between SCCA level and Japanese cedar pollen allergy was demonstrated.
   Conclusions: These results suggest that the serum SCCA level may be a useful biomarker to evaluate the severity of allergic rhinitis caused by D farinae.
C1 [Suzuki, Kumiko; Inokuchi, Akira; Kuratomi, Yuichiro] Saga Univ, Fac Med, Dept Otolaryngol Head & Neck Surg, Saga 8498501, Japan.
   [Miyazaki, Junji] Saga Prefectural Hosp Koseikan, Dept Otolaryngol Head & Neck Surg, Saga, Japan.
   [Izuhara, Kenji] Saga Med Sch, Dept Biomol Sci, Div Med Biochem, Saga, Japan.
RP Suzuki, K (reprint author), Saga Univ, Fac Med, Dept Otolaryngol Head & Neck Surg, 5-1-1 Nebeshima, Saga 8498501, Japan.
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   Nishi N, 2005, ANN ALLERG ASTHMA IM, V94, P391
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   Yuyama N, 2002, CYTOKINE, V19, P287, DOI 10.1006/cyto.2002.1972
NR 11
TC 4
Z9 4
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD JAN 10
PY 2010
VL 119
IS 1
BP 22
EP 26
PG 5
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 544SW
UT WOS:000273680600004
PM 20128182
ER

PT J
AU Songu, M
   Negrevergne, M
   Portmann, D
AF Songu, Murat
   Negrevergne, Michel
   Portmann, Didier
TI Negrevergne Otoplasty Technique
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE bat ear; otoplasty; pinnaplasty; protruding ear
AB Objectives: More than 200 different otoplasty procedures have been described in the literature to treat patients with prominent ears. However, no simple "best" technique exists.
   Methods: The Negrevergne otoplasty technique was developed by Michel Negrevergne and adopted in the Georges Port-mann Institute in France. The technique includes partial-thickness posterior scoring of the auricular cartilage by use of monopolar cutting diathermy.
   Results: A telephone survey was designed solely for this study, aimed to give general information about the technique's outcomes. The survey, conducted by the first author among his patients who were followed up for more than I year, revealed that most patients (46 of 52) were very to completely satisfied with the appearance and symmetry of their ears. Furthermore, evaluation according to the Global Aesthetic Improvement Scale was performed by a blinded nonparticipating observer using the medical photographs of 48 patients who consented to "medical photography" to evaluate the effect of treatment. All patients were rated as "improved" or better oil the Global Aesthetic Improvement Scale at 52 weeks. There were no ratings of "no change" or "worse."
   Conclusions: The Negrevergne otoplasty technique is a relatively simple and rapid procedure that maintains the natural contours of the auricle with little morbidity by addressing the poorly developed or absent antihelical fold, all abnormally large concha, and a prominent lobule.
C1 [Songu, Murat] Dr Behcet Uz Childrens Hosp, Dept Otorhinolaryngol, Izmir, Turkey.
   [Songu, Murat] Izmir Ataturk Res & Training Hosp, Dept Otorhinolaryngol, Izmir, Turkey.
   [Negrevergne, Michel] Univ Bordeaux, Pellegrin Hosp, Dept Otorhinolaryngol, Bordeaux, France.
   [Portmann, Didier] Georges Portmann Inst, Dept Otorhinolaryngol, Bordeaux, France.
RP Songu, M (reprint author), Dr Behcet Uz Childrens Hosp, Dept Otorhinolaryngol, Izmir, Turkey.
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   Patrick D. L., 1993, HLTH STATUS HLTH POL
   Petersson RS, 2008, CURR OPIN OTOLARYNGO, V16, P352, DOI 10.1097/MOO.0b013e328304b40d
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NR 13
TC 3
Z9 3
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD JAN 10
PY 2010
VL 119
IS 1
BP 27
EP 31
PG 5
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 544SW
UT WOS:000273680600005
PM 20128183
ER

PT J
AU Honda, K
   Haji, T
   Maruyama, H
AF Honda, Keigo
   Haji, Tomoyuki
   Maruyama, Hagino
TI Functional Results of Reinke's Edema Surgery Using a Microdebrider
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE functional results; microdebrider; Reinke's edema; surgical treatment
ID LARYNGEAL SURGERY; LESIONS
AB Objectives: We evaluated the functional results of Reinke's edema surgery using a microdebrider.
   Methods: In this prospective nonrandomized study from 2004 through 2008, functional surgery using a microdebrider was performed on patients with severe Reinke's edema. Comparisons were conducted for preoperative and postoperative phonatory function using both subjective grade (G), roughness (R), breathiness (B), asthenia (A), and strain (S) scoring and objective Multi-Di rnensional Voice Program parameters. Statistical analysis was done by paired t-test, and a p value of less than 0.05 was considered significant.
   Results: Seventeen patients were enrolled in this study, with a median age of 56 years and a median observation period of 129 days. The male-to-female ratio was 1 to 2.4. No major complications were observed in the perioperative period. Significant improvement was observed in the subjective values of G, R, B,and S. Improvement was also observed in the fundamental frequency, pitch perturbation quotient, and amplitude perturbation quotient calculated by the Multi-Dimensional Voice Program.
   Conclusions: The microdebrider is a useful tool in functional surgery for severe Reinke's edema and gives good functional outcomes. Surgeons can swiftly complete the key steps of removing pathological submucosal tissue and preserving the normal epithelium with an excellent surgical view.
C1 [Honda, Keigo] Natl Hosp Org, Kyoto Med Ctr, Dept Head & Neck Surg, Fushimi Ku, Kyoto 6128555, Japan.
   [Haji, Tomoyuki; Maruyama, Hagino] Kurashiki Cent Hosp, Dept Otolaryngol Head & Neck Surg, Okayama, Japan.
RP Honda, K (reprint author), Natl Hosp Org, Kyoto Med Ctr, Dept Head & Neck Surg, Fushimi Ku, 1-1 Fukakusa Mukaihata Cho, Kyoto 6128555, Japan.
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NR 14
TC 5
Z9 7
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD JAN 10
PY 2010
VL 119
IS 1
BP 32
EP 36
PG 5
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 544SW
UT WOS:000273680600006
PM 20128184
ER

PT J
AU Sidell, D
   Shamouelian, D
   Erman, A
   Gerratt, BR
   Chhetri, D
AF Sidell, Douglas
   Shamouelian, David
   Erman, Andrew
   Gerratt, Bruce R.
   Chhetri, Dinesh
TI Improved Tracheoesophageal Prosthesis Sizing in Office-Based
   Tracheoesophageal Puncture
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT 89th Annual Meeting of the American-Broncho-Esophagological-Association
CY MAY 28-29, 2009
CL Phoenix, AZ
SP Amer Broncho Esophagol Assoc
DE laryngectomee; tracheoesophageal speech; voice prosthesis
ID TOTAL LARYNGECTOMY; VOICE PROSTHESIS; TRANSNASAL ESOPHAGOSCOPY;
   RESTORATION
AB Objectives: Tracheoesophageal puncture (TEP) for postlaryngectomy speech is increasingly being performed as an office-based procedure. We review Our experience with office-based TEP and compare outcomes with those of operating room-based TEP. Our hypothesis was that office-based TEP results in improved prosthesis sizing, reducing the number of visits dedicated to prosthesis resizing.
   Methods: A retrospective chart review was performed of all patients who underwent secondary TEP at our institution from 2001 to 2008. The primary dependent measure was the change in the length of the voice prosthesis. We also evaluated the number of visits made to the speech-language pathologist for resizing before a stable prosthesis length was achieved, and the number of days between voice prosthesis placement and the date a stable prosthesis length was observed.
   Results: Thirty-one patients were included in this study. There was a significant difference in prosthesis length change between patients who had office-based TEP and patients who had operating room-based TEP (p < 0.001). In addition, the office-based cohort required fewer visits to the speech-language pathologist for TEP adjustments before a stable TEP length was achieved (p < 0.001).
   Conclusions: Voice prosthesis sizing was better in patients who had office-based TEP than in patients who had operating room-based TEP. This outcome is likely due to the lesser degree of swelling of the tracheoesophageal party wall ill the office-based procedure.
C1 [Sidell, Douglas; Shamouelian, David; Erman, Andrew; Gerratt, Bruce R.; Chhetri, Dinesh] Univ Calif Los Angeles, David Geffen Sch Med, Div Head & Neck Surg, Los Angeles, CA 90095 USA.
RP Sidell, D (reprint author), Univ Calif Los Angeles, David Geffen Sch Med, Div Head & Neck Surg, 10833 Le Conte Ave,62-132 CHS, Los Angeles, CA 90095 USA.
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NR 14
TC 3
Z9 3
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD JAN 10
PY 2010
VL 119
IS 1
BP 37
EP 41
PG 5
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 544SW
UT WOS:000273680600007
PM 20128185
ER

PT J
AU van Dinther, JJS
   Vercruysse, JP
   De Foer, B
   Somers, T
   Zarowski, A
   Casselman, J
   Offeciers, E
AF van Dinther, Joost J. S.
   Vercruysse, Jean-Philippe
   De Foer, Bert
   Somers, Thomas
   Zarowski, Andrzej
   Casselman, Jan
   Offeciers, Erwin
TI Subarcuate Supralabyrinthine Approach for Supralabyrinthine Petrosal
   Cholesteatoma
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT 8th International Conference on Cholesteatoma and Ear Surgery
CY JUN 15-20, 2008
CL Antalya, TURKEY
DE congenital cholesteatoma; hearing preservation; magnetic resonance
   imaging; non-echo-planar diffusion-weighted imaging; petrosal apex;
   subarcuate supralabyrinthine approach
ID MIDDLE-EAR CHOLESTEATOMA; TURBO SPIN-ECHO; SINGLE-SHOT; PLANAR
AB Congenital cholesteatomas of the petrosal apex account for 1% to 3% of all cholesteatomas and often present an important surgical challenge. This report describes an exceptional case of a "nondestructive" translabyrinthine surgical approach to a large congenital petrosal cholesteatoma that threatened the vestibulum, superior semicircular canal, facial nerve, and internal auditory canal. We applied a nonconventional transmastoid subarcuate supralabyrinthine approach in a 20-year-old patient by accessing the lesion through the center of the superior semicircular arch without damaging the integrity of the canal. This led to a complete removal of the petrosal cholesteatoma with preservation of hearing and vestibular function. Follow-up imaging performed 1 and 2 years after operation by means of non-echo-planar diffusion-weighted imaging did not show residual cholesteatoma. This report describes the first successful use of a subarcuate supralabyrinthine approach through the arches of the superior semicircular canal in a case of petrosal cholesteatoma.
C1 [van Dinther, Joost J. S.; Vercruysse, Jean-Philippe; Somers, Thomas; Zarowski, Andrzej; Offeciers, Erwin] St Augustinus Hosp, Univ Dept Otolaryngol Head & Neck Surg, B-2610 Antwerp, Belgium.
   [De Foer, Bert; Casselman, Jan] St Augustinus Hosp, Univ Dept Radiol, B-2610 Antwerp, Belgium.
RP van Dinther, JJS (reprint author), St Augustinus Hosp, Univ Dept Otolaryngol Head & Neck Surg, Oosterveldlaan 24, B-2610 Antwerp, Belgium.
CR De Foer B, 2007, NEURORADIOLOGY, V49, P841, DOI 10.1007/s00234-007-0268-3
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NR 19
TC 2
Z9 2
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD JAN 10
PY 2010
VL 119
IS 1
BP 42
EP 46
PG 5
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 544SW
UT WOS:000273680600008
PM 20128186
ER

PT J
AU Lewis, AF
   Carron, JD
   Vedanarayanan, V
AF Lewis, Andrea F.
   Carron, Jeffrey D.
   Vedanarayanan, Vetta
TI Congenital Bilateral Vocal Fold Paralysis and Charcot-Marie-Tooth
   Disease
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE Charcot-Marie-Tooth disease; vocal fold paralysis
ID CORD PARALYSIS; TYPE-1
AB We present the case of a patient with Charcot-Marie-Tooth disease (CMT) type 1 with congenital bilateral vocal fold paralysis in order to emphasize the treatment options and long-term outcome. The case is reviewed with regard to presentation, differential diagnosis, and treatment. We also reviewed the literature to determine the frequency of congenital and childhood presentations of bilateral vocal fold paralysis associated with CMT, most specifically CMT type 1. We found only 14 children reported to have bilateral vocal fold paralysis associated with CMT, and only 1 of these cases was associated with CMT type 1. None of these patients had congenital vocal fold paralysis. Because of the degenerative nature of the disease, our Patient underwent endoscopic cordotomy to avoid tracheotomy. We conclude that CMT should be included in the differential diagnosis in evaluating neonates with bilateral vocal fold paralysis. If CMT is definitively diagnosed, it Could alter the course of treatment.
C1 [Lewis, Andrea F.; Carron, Jeffrey D.] Univ Mississippi, Med Ctr, Dept Otolaryngol & Communicat Sci, Jackson, MS 39206 USA.
   [Vedanarayanan, Vetta] Univ Mississippi, Med Ctr, Dept Pediat, Jackson, MS 39206 USA.
RP Lewis, AF (reprint author), Univ Mississippi, Med Ctr, Dept Otolaryngol & Communicat Sci, 2500 N State St, Jackson, MS 39206 USA.
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NR 12
TC 3
Z9 4
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD JAN 10
PY 2010
VL 119
IS 1
BP 47
EP 49
PG 3
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 544SW
UT WOS:000273680600009
PM 20128187
ER

PT J
AU Rees, CJ
   Allen, J
   Postma, GN
   Belafsky, PC
AF Rees, Catherine J.
   Allen, Jacqueline
   Postma, Gregory N.
   Belafsky, Peter C.
TI Effects of Gold Laser on the Avian Chorioallantoic Membrane
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT 89th Annual Meeting of the American-Broncho-Esophagological-Association
CY MAY 28-29, 2009
CL Phoenix, AZ
SP Amer Broncho Esophagol Assoc
DE chorioallantoic membrane; Gold laser; larynx; laser; phonosurgery; vocal
   fold
ID PULSED DYE-LASER; SURGERY; MODEL; PAPILLOMATOSIS; ADENOIDECTOMY;
   DYSPLASIA; EFFICACY
AB Objectives: Office-based lasers have revolutionized the treatment of laryngeal disease. The 980-nm Gold laser is a device that may offer some practical advantages over other office lasers. The chick chorioallantoic membrane has been proposed as a model for predicting the effects of photoangiolytic lasers on vocal fold microvasculature. We sought to evaluate the effects of the Gold laser in this model.
   Methods: Vascular reactions in first-order vessels were determined for the Gold laser with both 0 degrees straight and 30 degrees angled laser fibers. Vessels were treated at 15 W and a 500-ms pulse interval, with a 1-mm working distance. Pulse widths C, of 300 ms and 500 ins were evaluated. All vessels were treated until selective coagulation or vessel rupture.
   Results: We performed 60 trials on 30 embryos. The mean energy delivered was 33.7 J for the straight fiber and 51.2 J for the angled fiber. The laser achieved selective vessel coagulation without rupture in 100% (30 of 30) of straight fiber trials and in 100% (30 of 30) of angled fiber trials. In 6.7% (2 of 30) of straight fiber and 10% (3 of 30) of angled fiber trials, it caused minor injury to the surrounding albumin as indicated by white coagulum outside the vessel.
   Conclusions: The Gold laser effectively coagulates small vessels without rupture at a working distance of 1 mm and settings of 15 W, 500-ms pulse interval, and 300- to 500-ms pulse width.
C1 [Belafsky, Peter C.] Univ Calif Davis, Med Ctr, Sch Med, Dept Otolaryngol Head & Neck Surg, Sacramento, CA 95825 USA.
   [Postma, Gregory N.] Med Coll Georgia, Dept Otolaryngol Head & Neck Surg, Augusta, GA 30912 USA.
RP Belafsky, PC (reprint author), Univ Calif Davis, Med Ctr, Sch Med, Dept Otolaryngol Head & Neck Surg, 2521 Stockton Blvd,Suite 7200, Sacramento, CA 95825 USA.
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   Mortensen MM, 2008, LARYNGOSCOPE, V118, P1884, DOI 10.1097/MLG.0b013e31817d7546
   Mouadeb DA, 2007, OTOLARYNG HEAD NECK, V137, P477, DOI 10.1016/j.otohns.2007.02.003
   Rees CJ, 2006, OTOLARYNG HEAD NECK, V134, P1023, DOI 10.1016/j.otohns.2006.01.019
   Worley NK, 2007, LARYNGOSCOPE, V117, P2026, DOI 10.1097/MLG.0b013e31812e95fa
   Zeitels SM, 2004, ANN OTO RHINOL LARYN, V113, P265
   Zeitels Steven M, 2007, Curr Opin Otolaryngol Head Neck Surg, V15, P394, DOI 10.1097/MOO.0b013e3282f1fbb2
   Zeitels SM, 2006, ANN OTO RHINOL LARYN, V115, P679
NR 13
TC 1
Z9 1
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD JAN 10
PY 2010
VL 119
IS 1
BP 50
EP 53
PG 4
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 544SW
UT WOS:000273680600010
PM 20128188
ER

PT J
AU Scott, AR
   Chong, PST
   Hartnick, CJ
   Randolph, GW
AF Scott, Andrew R.
   Chong, Peter Siao Tick
   Hartnick, Christopher J.
   Randolph, Gregory W.
TI Spontaneous and Evoked Laryngeal Electromyography of the Thyroarytenoid
   Muscles: A Canine Model for Intraoperative Recurrent Laryngeal Nerve
   Monitoring
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT 88th Annual Meeting of the American-Broncho-Esophagological-Association
CY MAY 01-02, 2008
CL Orlando, FL
SP Amer Broncho Esophagol Assoc
DE canine recurrent laryngeal nerve model; laryngeal electromyography;
   recurrent laryngeal nerve monitoring
ID VOCAL FOLD PARALYSIS
AB Objectives: We sought to determine the feasibility of performing spontaneous and evoked intraoperative laryngeal electromyography (L-EMG) using nerve monitoring equipment and to compare recording electrode configurations and methods of recurrent laryngeal nerve (RLN) stimulation in dogs.
   Methods: Four beagles underwent crush injury of the left RLN, and 2 beagles underwent left RLN transection. Serial spontaneous and evoked L-EMG was recorded with the NIM-Response nerve monitoring system under sedation. Transesophageal, percutaneous, and direct open RLN stimulation was performed. Recordings of spontaneous and evoked responses were made with endotracheal tube surface electrodes and bipolar vocal fold needle electrodes. The L-EMG procedures were repeated every 1 to 2 weeks after injury, and intersubject and intertrial differences were evaluated.
   Results: Low-amplitude motor unit action potentials, polyphasic potentials, fasciculations, and fibrillations were detected in injured animals with bipolar needle recording electrodes with this system of spontaneous L-EMG. The surface recording electrodes did not detect pathologic waveforms. Percutaneous needle stimulation of the RLN is possible at Currents slightly higher than those used for direct stimulation. Consistent, discrete, transesophageal stimulation of the RLN could not be reliably performed. Recording evoked responses with needle electrodes generated sharper waveforms, facilitating calculation of latency and wave duration. Evoked L-EMG utilizing surface recording electrodes limited the intertrial and intersubject variability of evoked amplitude.
   Conclusions: Typical patterns of nerve injury can be detected with this system of intraoperative L-EMG in a canine model. Quantitative measures of amplitude, latency, and wave duration in healthy and injured canine RLNs may be determined with this system.
C1 [Randolph, Gregory W.] Massachusetts Eye & Ear Infirm, Dept Otol & Laryngol, Div Thyroid & Parathyroid Surg, Boston, MA 02114 USA.
   [Scott, Andrew R.; Hartnick, Christopher J.; Randolph, Gregory W.] Massachusetts Eye & Ear Infirm, Dept Otol & Laryngol, Div Pediat, Boston, MA 02114 USA.
   [Chong, Peter Siao Tick] Harvard Univ, Sch Med, Dept Neurol, Massachusetts Gen Hosp, Boston, MA 02115 USA.
   [Randolph, Gregory W.] Harvard Univ, Sch Med, Dept Surg, Massachusetts Gen Hosp,Div Surg Oncol, Boston, MA 02115 USA.
   [Randolph, Gregory W.] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Endocrine Surg Serv, Boston, MA 02115 USA.
RP Randolph, GW (reprint author), Massachusetts Eye & Ear Infirm, Dept Otol & Laryngol, Div Thyroid & Parathyroid Surg, 243 Charles St, Boston, MA 02114 USA.
CR Gardner GM, 2000, INT J PEDIATR OTORHI, V52, P37, DOI 10.1016/S0165-5876(99)00288-8
   LEVINE BA, 1995, ARCH OTOLARYNGOL, V121, P116
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   Quan D, 1999, U PA ORTHOP J, V12, P45
   Randolph GW., 2003, SURG THYROID PARATHY, P300
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   Xu W, 2007, ANN OTO RHINOL LARYN, V116, P576
   Zealear DL, 2005, ANN OTO RHINOL LARYN, V114, P563
NR 12
TC 11
Z9 12
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD JAN 10
PY 2010
VL 119
IS 1
BP 54
EP 63
PG 10
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 544SW
UT WOS:000273680600011
PM 20128189
ER

PT J
AU Hartl, DM
   Hans, S
   Crevier-Buchman, L
   Vaissiere, J
   Brasnu, DF
AF Hartl, Dana M.
   Hans, Stephane
   Crevier-Buchman, Lise
   Vaissiere, Jacqueline
   Brasnu, Daniel F.
TI Long-Term Acoustic Comparison of Thyroplasty Versus Autologous Fat
   Injection
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT 89th Annual Meeting of the American-Broncho-Esophagological-Association
CY MAY 28-29, 2009
CL Phoenix, AZ
SP Amer Broncho Esophagol Assoc
DE acoustics; medialization; paralysis; vocal fold; voice
ID VOCAL CORD AUGMENTATION; AUTOGENOUS FAT; PARALYSIS; MEDIALIZATION;
   LARYNGOPLASTY; EXPERIENCE
AB Objectives: Medialization by thyroplasty or intracordal autologous fat injection provides voice improvement in patients with unilateral vocal fold paralysis. Thyroplasty is considered a "permanent" medialization, whereas fat injection is considered "temporary" because of reabsorption. The objective of this study was to compare the evolution of acoustic parameters for these procedures over I year and to evaluate the results of fat injection at 2 years.
   Methods: From 1994 to 1998, 46 consecutive patients ( 17 women and 29 men) were treated exclusively by intracordal injection of autologous fat, and then from 1999 to 2002, 48 Consecutive patients (19 women and 29 men) were treated with the Montgomery Thyroplasty Implant System or Gore-Tex thyroplasty. Each patient's voice was prospectively recorded before operation and at 1, 3, 12, and 24 months after operation. Six patients (13%) in the injection group underwent a second injection, and I patient (2%) in the thyroplasty group underwent revision surgery. Jitter, shimmer, and noise-to-harmonics ratio (NHR) were calculated for a 1,000-ms midvowel segment of the vowel /a/.
   Results: One month after operation, jitter, shimmer, and NHR were significantly improved in both groups (Wilcoxon's test, p < 0.05 in all cases). Jitter and shimmer did not change significantly between I and 3 months or between I and 12 months (p > 0.05). The NHR had improved at 12 months in both groups (injection, p = 0.0004; thyroplasty, p = 0.0178) and at 24 months in the injection group (p = 0.0076). No significant difference was noted between the two techniques before operation or at 1, 3, or 12 months after operation (Mann-Whitney test, p > 0.05). Jitter and shimmer had not changed significantly after 24 months in either group. At 24 months, there was no difference in acoustic parameters between the two treatment groups.
   Conclusions: The two techniques provided comparable objective acoustic voice improvement. At 2 years, autologous fat injection provides long-term acoustic voice improvement comparable to that of thyroplasty, but it has a higher rate of revision surgery.
C1 [Hartl, Dana M.] Inst Gustave Roussy, Dept Otolaryngol Head & Neck Surg, F-94805 Villejuif, France.
   [Hartl, Dana M.; Hans, Stephane; Crevier-Buchman, Lise; Brasnu, Daniel F.] Univ Paris 05, CNRS, European Hosp Georges Pompidou, AP HP,Voice Biomat & Head & Neck Oncol Res Lab, Paris, France.
   [Hartl, Dana M.; Hans, Stephane; Crevier-Buchman, Lise; Vaissiere, Jacqueline; Brasnu, Daniel F.] CNRS, Phonet & Phonol Lab, UMR Sorbonne Nouvelle 7018, F-75700 Paris, France.
RP Hartl, DM (reprint author), Inst Gustave Roussy, Dept Otolaryngol Head & Neck Surg, 39 Rue Camille Desmoulins, F-94805 Villejuif, France.
CR BAUER CA, 1995, ANN OTO RHINOL LARYN, V104, P871
   Boersma P, PRAAT DOING PHONETIC
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   Clauser L, 2008, J CRANIOFAC SURG, V19, P871
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NR 26
TC 8
Z9 8
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD DEC
PY 2009
VL 118
IS 12
BP 827
EP 832
PG 6
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 538EL
UT WOS:000273166900001
PM 20112515
ER

PT J
AU Mortensen, M
   Ivey, CM
   Iida, M
   Woo, P
AF Mortensen, Melissa
   Ivey, Chandra M.
   Iida, Minoru
   Woo, Peak
TI Superior Thyroid Cornu Syndrome: An Unusual Cause of Cervical Dysphagia
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE dysphagia; odynophagia; thyroid cartilage
ID CARTILAGE ANATOMY; VARIANT; THROAT
AB Objectives: ossification of a Superior thyroid cornu in men may cause pharyngeal airway impingement and result in cervical dysphagia. We report on a clinical case series of this rare condition. called superior thyroid cornu syndrome. This is the first report of a case series of this entity as a possible cause of cervical dysphagia that was successfully treated with an endoscopic procedure.
   Methods: A clinical case series of 12 patients were identified as having superior thyroid cornu syndrome (years 2001 to 2006). Eleven patients were male and I was female; their mean age was 54.6 years. They complained of unresolved throat pain. difficulty swallowing, and/or pain on swallowing. On flexible laryngoscopy, there was an asymmetric indentation of the pharynx due to a prominent Superior thyroid cornu. Laryngeal manipulation produced the pain and exposed the prominent cornu in the airway. Computed tomographic evidence of calcification of the superior thyroid horn without other abnormality was noted.
   Results: After maximal medical treatment with proton pump inhibitors, anti-inflammatory agents, nasal steroids, antihistamines. and/or other allergy treatments, 8 of the patients who had persistent symptoms were treated by transoral pharyngotomy and resection of an approximately 2.0 x 0.5-cm segment of a thyroid cornu. Vast improvement in symptoms occurred in 6 patients, and complete symptom resolution occurred in 3 of those 6. Two of 8 patients reported improvement in swallowing, but persistent pain. The follow-up duration was between 2 and 15 months from the time of surgery.
   Conclusions: Superior thyroid cornu syndrome may be a rare cause of cervical dysphagia. It may be diagnosed by careful laryngoscopy with laryngeal palpation followed by a Computed tomography scan. Surgical resection of the affected superior thyroid cornu by transoral pharyngotomy appears to be effective in relief of symptoms.
C1 [Mortensen, Melissa] Univ Virginia Hlth Syst, Dept Otolaryngol Head & Neck Surg, Charlottesville, VA 22908 USA.
   [Ivey, Chandra M.; Woo, Peak] Mt Sinai Sch Med, Dept Otolaryngol Head & Neck Surg, New York, NY USA.
   [Iida, Minoru] Jikei Univ, Dept Otolaryngol, Tokyo, Japan.
RP Mortensen, M (reprint author), Univ Virginia Hlth Syst, Dept Otolaryngol Head & Neck Surg, POB 800713, Charlottesville, VA 22908 USA.
CR AVRAHAMI E, 1994, CLIN RADIOL, V49, P683, DOI 10.1016/S0009-9260(05)82659-5
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   HIRANO M, 1989, ANN OTO RHINOL LARYN, V98, P135
   Lin D, 2005, DYSPHAGIA, V20, P232, DOI 10.1007/s00455-005-0012-2
   Nadig SK, 2006, J LARYNGOL OTOL, V120, P608, DOI 10.1017/S0022215106001125
   Smith ME, 2001, ARCH OTOLARYNGOL, V127, P1129
NR 7
TC 2
Z9 2
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD DEC
PY 2009
VL 118
IS 12
BP 833
EP 838
PG 6
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 538EL
UT WOS:000273166900002
PM 20112516
ER

PT J
AU Hart, CK
   Theodosopoulos, PV
   Zimmer, LA
AF Hart, Catherine K.
   Theodosopoulos, Phillip V.
   Zimmer, Lee A.
TI Anatomy of the Optic Canal: A Computed Tomography Study of Endoscopic
   Nerve Decompression
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE anatomy; endoscopy; optic canal; optic nerve; sphenoid sinus
ID NEUROPATHY; SINUSES
AB Objectives: Endoscopic optic nerve decompression has variable success rates. Our goal was to further delineate the radiographic anatomy of the optic canal to determine whether the variable success can be explained on anatomic principles.
   Methods: The optic canal dimensions and the degree of optic canal exposure to the sphenoid sinus were measured on sinus computed tomography images of 96 patients.
   Results: A total of 191 optic canals were analyzed (111 female subjects and 80 male subjects). The average medial canal wall length was 1.48 cm (range, 0.7 to 2.3 cm). The length in male subjects wits 1.61 cm (range, 1.1 to 2.3 cm), as compared to 1.39 cm (range, 0.7 to 2.0 cm) in female subjects (p < 0.001). Onodi cells and pneumatized anterior clinoid processes were present on 14 and 16 images, respectively. The average degree of exposure of the optic canal to the sphenoid sinus in optic canals without Onodi cells or clinoid pneumatization was 99.3 degrees, and in optic canals with both Onodi cells and clinoid pneumatization it was 117.7 degrees. The potential area of canal exposed was 0.66 cm(2), or 28% of the total surface area.
   Conclusions: A wide variation in medial canal wall length and exposure of the optic canal to the sphenoid sinus exists on computed tomography images. Variation in medial canal wall length and optic canal exposure may limit the Surface area of nerve available for endoscopic optic nerve decompression.
C1 [Hart, Catherine K.; Zimmer, Lee A.] Univ Cincinnati, Med Ctr, Dept Otolaryngol Head & Neck Surg, Cincinnati, OH 45267 USA.
   [Theodosopoulos, Phillip V.] Univ Cincinnati, Med Ctr, Dept Neurosurg, Cincinnati, OH 45267 USA.
   [Theodosopoulos, Phillip V.] Univ Cincinnati, Med Ctr, Mayfield Clin, Cincinnati, OH 45267 USA.
RP Zimmer, LA (reprint author), Univ Cincinnati, Med Ctr, Dept Otolaryngol Head & Neck Surg, 231 Albert Sabin Way, Cincinnati, OH 45267 USA.
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   DeLano MC, 1996, AM J NEURORADIOL, V17, P669
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   Kountakis SE, 2000, OTOLARYNG HEAD NECK, V123, P34, DOI 10.1067/mhn.2000.106007
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NR 18
TC 5
Z9 6
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD DEC
PY 2009
VL 118
IS 12
BP 839
EP 844
PG 6
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 538EL
UT WOS:000273166900003
PM 20112517
ER

PT J
AU Gacek, RR
AF Gacek, Richard R.
TI Fusion as an Evolutionary Principle of the Vertebrate Labyrinth
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE evolution; labyrinth; utricle
ID STATOACOUSTIC NERVE; NEUROTROPHIC FACTOR; VESTIBULAR NEURONS; MICE;
   ORGANIZATION; OCULOMOTOR; NYSTAGMUS; NEGLECTA; ANATOMY; CAT
AB Objectives: This Study was undertaken to demonstrate changes in the innervation of vestibular and auditory sense organs with the evolutionary ascent of the vertebrate labyrinth.
   Methods: Dissected labyrinths and their nerve supply prepared by the Sudan black B technique of Rasmussen were examined and photographed with a Canon A 100 camera interfaced with a Zeiss operating microscope.
   Results: In lizards and alligators, the utricular sense organ is represented by 2 small maculae, each with a separate nerve branching off the ampullary nerves to the anterior and lateral canal cristae. These 2 maculae fuse into a bilobed macula with ascent in frogs and pigeons, eventually becoming a single large macula with its nerve supply from the superior vestibular division in guinea pigs, cats, lions, monkeys,and humans. Along with these changes, there is a fusion of the lateral and anterior canal ampullary nerves and of the bifurcating branches of the vertical canal ampullary nerves. The saccular macula is single, but receives a dual innervation from the superior division (anterior ramus) and the inferior division (posterior ramus) of the eighth nerve in alligators, pigeons, guinea pigs, cats, lions, monkeys, and humans. The main innervation is usually from the inferior division; however, saccular innervation is from the inferior division in lizards and from the superior division in frogs. The auditory sense organ is represented by a curved tube with a low-frequency receptor (lagena) at its distal end in lizards, alligators, and pigeons. In mammals, in which there is a coiled cochlea with a variable number of turns, low frequencies are recorded at the apical turn. This configuration may represent fusion of the lagena into the apical end of the auditory sense organ.
   Conclusions: Fusion of sense organs and of their nerve supply appears to be an evolutionary principle in the vertebrate labyrinth.
C1 Univ Massachusetts, Sch Med, Dept Otolaryngol, Worcester, MA 01655 USA.
RP Gacek, RR (reprint author), Univ Massachusetts, Sch Med, Dept Otolaryngol, 55 Lake Ave N, Worcester, MA 01655 USA.
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NR 30
TC 0
Z9 0
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD DEC
PY 2009
VL 118
IS 12
BP 845
EP 851
PG 7
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 538EL
UT WOS:000273166900004
PM 20112518
ER

PT J
AU Salvinelli, F
   Miele, A
   Rinaldi, V
   Pappacena, M
   Trivelli, M
AF Salvinelli, Fabrizio
   Miele, Angela
   Rinaldi, Vittorio
   Pappacena, Marco
   Trivelli, Maurizio
TI Study of Vestibular Evoked Myogenic Potentials in Patients Affected by
   Meniere's Disease Treated With Endolymphatic Mastoid Shunt
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE hydrops; Meniere's disease; sac surgery; vertigo
ID INTRATYMPANIC GENTAMICIN; DECOMPRESSION; SURGERY; THERAPY
AB Objectives: We recorded and compared the vestibular evoked myogenic potentials (VEMPs) before use of an endolymphatic mastoid shunt (EMS) and 1, 12, and 48 months after placement of the shunt.
   Methods: Air-conducted VEMPs were recorded in 28 patients affected by intractable Meniere's disease and treated with placement of an EMS.
   Results: One month and 12 months after the surgery, VEMPs were not detectable in the operated ear in 100% and 86% of the patients, respectively. Forty-eight months after the surgery, they were elicited in 79% of the patients.
   Conclusions: We conclude that VEMPs are a clinically useful tool in the postoperative follow-up of patients with an EMS.
C1 [Salvinelli, Fabrizio; Miele, Angela; Rinaldi, Vittorio; Pappacena, Marco; Trivelli, Maurizio] Campus Biomed Univ, Area Otolaryngol, I-00128 Rome, Italy.
RP Rinaldi, V (reprint author), Campus Biomed Univ, Area Otolaryngol, Via Alvaro Portillo 21, I-00128 Rome, Italy.
CR AREMBERG IK, 1982, OTOLARYNGOL CLIN N A, V15, P869
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   de Waele C, 1999, AM J OTOL, V20, P223
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   Kakigi A, 2006, ORL J OTO-RHINO-LARY, V68, P279, DOI 10.1159/000093299
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   Ozluoglu LN, 2008, ACTA OTO-LARYNGOL, V128, P422, DOI 10.1080/00016480701808988
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   Shojaku H, 2001, ACTA OTO-LARYNGOL, P65
   Trivelli M, 2008, ACTA OTO-LARYNGOL, V128, P314, DOI 10.1080/00016480701558914
   Young YH, 2003, ARCH OTOLARYNGOL, V129, P815, DOI 10.1001/archotol.129.8.815
   1995, OTOLARYNOL HEAD NECK, V113, P181
NR 19
TC 0
Z9 0
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD DEC
PY 2009
VL 118
IS 12
BP 852
EP 858
PG 7
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 538EL
UT WOS:000273166900005
PM 20112519
ER

PT J
AU Felix-Trujillo, MM
   Valdez-Martinez, E
   Ramirez, JE
   Lozano-Morales, R
AF Martin Felix-Trujillo, Manuel
   Valdez-Martinez, Edith
   Eduardo Ramirez, Jorge
   Lozano-Morales, Ramon
TI Surgical and Medical Treatment of Hearing Loss in Mixed Otosclerosis
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE hearing loss; otosclerosis; sodium fluoride; stapedectomy
ID SODIUM-FLUORIDE TREATMENT; COCHLEAR OTOSCLEROSIS; FOLLOW-UP;
   OTOSPONGIOSIS; STAPEDECTOMY; THERAPY; DISEASE
AB Objectives: We assessed the effect of using preoperative sodium fluoride (NaF) on the difficulty of working with the footplate during stapedectomy and its effect on the postsurgical hearing gain in patients with mixed otosclerosis (ie, otosclerosis and/or otospongiosis).
   Methods: There were 2 groups of patients with mixed otosclerosis. The experimental group was made up of patients with an active focus of the disease; they received NaF for 6 months and then underwent stapedectomy. The control group was made up of patients with an inactive focus of the disease: they underwent stapedectomy without administration of NaF.
   Results: The difference between the study groups in the degree of difficulty in extracting the footplate was not found to be statistically significant. Both groups had hearing gains in bone and air conduction. The level of posttreatment hearing gain in the group exposed to NaF was greater than that in the nonexposed group.
   Conclusions: Sodium fluoride administered to patients with mixed otosclerosis and an active focus of disease does not increase the difficulty of working with the footplate during stapedectomy, and it increases the hearing gain after the procedure.
C1 [Martin Felix-Trujillo, Manuel; Eduardo Ramirez, Jorge; Lozano-Morales, Ramon] Gen Hosp, Dept Otorhinolaryngol Head & Neck Surg, Natl Med Ctr La Raza, Mexican Inst Social Secur, Mexico City, DF, Mexico.
   [Valdez-Martinez, Edith] Mexican Inst Social Secur, Hlth Res Council, Mexico City, DF, Mexico.
RP Felix-Trujillo, MM (reprint author), Flores Magon 209,Edificio Aldama,Entrada F,Dept 2, Mexico City 06700, DF, Mexico.
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NR 40
TC 0
Z9 0
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD DEC
PY 2009
VL 118
IS 12
BP 859
EP 865
PG 7
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 538EL
UT WOS:000273166900006
PM 20112520
ER

PT J
AU Bernstein, JM
   Brooks, SP
   Lehman, HK
   Pope, L
   Sands, A
   Shultz, LD
   Bankert, RB
AF Bernstein, Joel M.
   Brooks, Stephen P.
   Lehman, Heather K.
   Pope, Liza
   Sands, Amy
   Shultz, Leonard D.
   Bankert, Richard B.
TI Human Nasal Polyp Microenvironments Maintained in a Viable and
   Functional State as Xenografts in NOD-scid IL2r gamma(null) Mice
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE mucin; nasal polyp; splenomegaly; xenograft
ID HUMAN-LUNG-TUMOR; CELL-DEVELOPMENT; LONG-TERM; ENGRAFTMENT; TISSUE;
   MOUSE; CHAIN; DNA
AB Objectives: The objective was to develop a model with which to study the cellular and molecular events associated with nasal polyp progression. To accomplish this, we undertook to develop a system in which nondisrupted human nasal polyp tissue could be successfully implanted into severely immunocompromised mice, in which the histopathology of the original nasal polyp tissue, including inflammatory lymphocytes, epithelial and goblet cell hyperplasia and subepithelial fibrosis, could be preserved for prolonged periods.
   Methods: Small, non-disrupted pieces of human nasal polyp tissues were subcutaneously implanted into NOD-scid IL2r gamma(null) mice. Xeno-rafts at 8 to 12 weeks after implantation were examined histologically and immunohistochemically to identify human inflammatory leukocytes and to determine whether the characteristic histopathologic characteristics of the nasal polyps were maintained for a prolonged period. The xenografts, spleen, lung, liver, and kidneys were examined histologically and immunohistochemically and were evaluated for changes in volume. The sera of these mice were assayed for human cytokines and immunoglobulin.
   Results: Xenografts of human nasal polyp tissues were established after their subcutaneous implantation into NOD-scid IL2r gamma(null) mice. The xenografts were maintained in a viable and functional state for up to 3 months, and retained a histopathologic appearance similar to that of the original tissue, with a noticeable increase in goblet cell hyperplasia and marked mucus accumulation in the submucosal glands compared to the original nasal polyp tissue. Inflammatory lymphocytes present in the polyp microenvironment were predominantly human CD8+ T cells with an effector memory phenotype. Human CD4+ T cells, CD138+ plasma cells, and CD68+ macrophages were also observed in the xenografts. Human immunoglobulin and interferon-gamma were detected in the sera of xenograft-bearing mice. The polyp-associated lymphocytes proliferated and were found to migrate from the xenografts to the spleens of the recipient mice, resulting in a significant splenomegaly. A progressive increase in the volume of the xenografts was observed with little or no evidence of mouse cell infiltration into the human leukocyte antigen-positive human tissue. An average twofold increase in polyp volume was found at 3 months after engraftment.
   Conclusions: The use of innate and adaptive immunodeficient NOD-scid mice homozygous for targeted mutations in the interleukin-2 receptor gamma-chain locus NOD-scid IL2r gamma(null) for establishing xenografts of nondisrupted pieces of human nasal polyp tissues represents a significant improvement over the previously reported xenograft model that used partially immunoincompetent CB17-scid mice as tissue recipients. The absence of the interleukin-2 receptor gamma-chain results in complete elimination of natural killer cell development, as well as severe impairments in T and B cell development. These mice, lacking both innate and adaptive immune responses, significantly improve upon the long-term engraftment of human nasal Polyp tissues and provide a model with which to Study how nasal polyp-associated lymphocytes and their secreted biologically active products contribute to the histopathology and progression of this chronic inflammatory disease.
C1 [Bernstein, Joel M.] SUNY Buffalo, Dept Otolaryngol, Sch Med & Biomed Sci, Buffalo, NY 14260 USA.
   [Brooks, Stephen P.; Pope, Liza; Bankert, Richard B.] SUNY Buffalo, Dept Microbiol & Immunol, Sch Med & Biomed Sci, Buffalo, NY 14260 USA.
   [Bernstein, Joel M.; Lehman, Heather K.] SUNY Buffalo, Dept Pediat, Sch Med & Biomed Sci, Buffalo, NY 14260 USA.
   [Sands, Amy] SUNY Buffalo, Dept Pathol, Sch Med & Biomed Sci, Buffalo, NY 14260 USA.
   [Bernstein, Joel M.] SUNY Buffalo, Dept Communicat Disorders & Sci, Buffalo, NY 14260 USA.
   [Shultz, Leonard D.] Jackson Lab, Bar Harbor, ME 04609 USA.
RP Bernstein, JM (reprint author), 2430 N Forest Rd, Getzville, NY 14068 USA.
CR Bankert RB, 2001, TRENDS IMMUNOL, V22, P386, DOI 10.1016/S1471-4906(01)01943-3
   Bernstein JM, 2006, ANN OTO RHINOL LARYN, V115, P65
   Bernstein JM, 1997, J ALLERGY CLIN IMMUN, V99, P165, DOI 10.1016/S0091-6749(97)70091-5
   Bernstein JM, 2004, OTOLARYNG HEAD NECK, V130, P526, DOI 10.1016/j.otohns.2003.12.022
   Bernstein JM, 2004, AM J RHINOL, V18, P62
   Bernstein J M, 2001, Curr Allergy Asthma Rep, V1, P262, DOI 10.1007/s11882-001-0017-3
   Gevaert P, 2005, ALLERGY, V60, P71, DOI 10.1111/j.1398-9995.2004.00621.x
   Hoffmann M, 2000, ACTA OTO-LARYNGOL, V120, P872, DOI 10.1080/000164800750061750
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   Simpson-Abelson MR, 2008, J IMMUNOL, V180, P7009
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NR 20
TC 1
Z9 1
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD DEC
PY 2009
VL 118
IS 12
BP 866
EP 875
PG 10
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 538EL
UT WOS:000273166900007
PM 20112521
ER

PT J
AU Ledl, C
   Mertl-Roetzer, M
AF Ledl, Christian
   Mertl-Roetzer, Marion
TI Tracheal and Tracheostomal Hypergranulation and Related Stenosis in
   Long-Term Cannulated Patients: Does the Tracheostomy Procedure Make a
   Difference?
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE hypergranulation; long-term effect; tracheostomy; tracheotomy
ID PERCUTANEOUS DILATATIONAL TRACHEOSTOMY; CRITICALLY-ILL PATIENTS;
   SURGICAL TRACHEOSTOMY; FOLLOW-UP; DILATIONAL TRACHEOSTOMY;
   RANDOMIZED-TRIAL; METAANALYSIS; TRACHEOTOMY
AB Objectives: Long-term cannulated patients are at risk of developing tracheal and tracheostomal hypergranulation. This study evaluated the incidence of hypergranulation and related tracheal stenosis in long-term cannulated patients. The relation between hypergranulation, specific tracheostomy techniques, and the duration of cannulation was investigated.
   Methods: A prospective observational study was conducted to analyze tracheostomal and tracheal hypergranulation in long-term cannulated patients. We compared complication rates in 344 postacute patients. Tracheas and tracheostomas were inspected visually and endoscopically at admission and at regular tube changes every 2 weeks until decannulation or discharge.
   Results: Hypergranulation appeared 3 times as often in the tracheostoma (n = 338) as in the trachea (n = 109). There was no influence of the tracheostomy procedure on the frequency (p = 0.931), location (tracheostoma, p = 0.947; trachea, p 0.918), or severity (stenoses grade 1, p = 0.910; grade 11, p = 0.649; grade 111, p = 0.304) of the hypergranulation. The main factors to account for hypergranulation were the duration of cannulation (p < 0.001) and age (p = 0.033).
   Conclusions: There was no influence of tracheostomy techniques on hypergranulation. Its development depends on the duration of cannulation. It is recommended to keep the duration of cannulation as short as possible with respect to the underlying neurologic impairment.
C1 [Ledl, Christian; Mertl-Roetzer, Marion] Neurol Hosp Bad Aibling, Dept Speech Language & Swallowing Disorders, Bad Aibling, Germany.
RP Ledl, C (reprint author), Neurol Klin Bad Aibling, Kolbermoorerstr 72, D-83043 Bad Aibling, Germany.
CR Antonelli M, 2005, CRIT CARE MED, V33, P1015, DOI 10.1097/01.CCM.0000163401.77581.86
   Delaney A, 2006, CRIT CARE, V10, DOI 10.1186/cc4887
   Farr MJ, 2006, ANAESTHESIA, V61, P285, DOI 10.1111/j.1365-2044.2005.04508.x
   Gysin C, 1999, ANN SURG, V230, P708, DOI 10.1097/00000658-199911000-00014
   HAZARD P, 1991, CRIT CARE MED, V19, P1018, DOI 10.1097/00003246-199108000-00008
   Higgins KM, 2007, LARYNGOSCOPE, V117, P447, DOI 10.1097/01.mlg.0000251585.31778.c9
   Kearney PA, 2000, ANN SURG, V231, P701, DOI 10.1097/00000658-200005000-00010
   Koitschev A, 2003, CRIT CARE MED, V31, P1574, DOI 10.1097/01.CCM.0000065189.64560.A8
   Koitschev A, 2006, ANAESTHESIA, V61, P832, DOI 10.1111/j.1365-2044.2006.04748.x
   Melloni G, 2002, J CARDIOVASC SURG, V43, P113
   Raine RI, 1999, BRIT J ANAESTH, V82, P168
   Richard I, 2005, ANN FR ANESTH, V24, P659, DOI 10.1016/j.annfar.2005.03.010
   Silvester W, 2006, CRIT CARE MED, V34, P2145, DOI 10.1097/01.CCM.0000229882.09677.FD
   Tabaee A, 2005, LARYNGOSCOPE, V115, P1685, DOI 10.1097/01.MLG.0000175539.25182.2A
   Wu Jackson Jer-Kan, 2003, J Chin Med Assoc, V66, P467
   Yaremchuk K, 2003, LARYNGOSCOPE, V113, P1, DOI 10.1097/00005537-200301000-00001
NR 16
TC 3
Z9 3
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD DEC
PY 2009
VL 118
IS 12
BP 876
EP 880
PG 5
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 538EL
UT WOS:000273166900008
PM 20112522
ER

PT J
AU Kutluhan, A
   Bozdemir, K
   Cetin, H
   Yalciner, G
   Salviz, M
   Sari, N
   Deger, HM
   Bilgen, AS
AF Kutluhan, Ahmet
   Bozdemir, Kazim
   Cetin, Hueseyin
   Yalciner, Goekhan
   Salviz, Mehti
   Sari, Neslihan
   Deger, Hasan Mervan
   Bilgen, Akif Sinan
TI Endoscopic Balloon Dilation Sinuplasty Including Ethmoidal Air Cells in
   Chronic Rhinosinusitis
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE balloon sinuplasty; chronic rhinosinusitis; endoscopic sinus surgery
ID SINUS SURGERY; CATHETER SINUSOTOMY; FOLLOW-UP; COMPLICATIONS;
   FEASIBILITY; OUTCOMES; SAFETY; DILATATION; PATIENT; OSTIA
AB Objectives: We present the results Of Our experience with balloon catheter sinusotomy (BCS) in patients who had chronic rhinosinusitis.
   Methods: The medical records of 30 patients who were treated for chronic sinusitis with the BCS technique between April 2007 and February 2008 were reviewed retrospectively. Preoperative and postoperative assessments were performed by endoscopic endonasal examination and Lund-Mackay radiologic staging of paranasal sinus computed tomography scans. The symptom scoring was performed with the Sino-Nasal Outcome Test-20 (SNOT-20). The postoperative follow-Lip period was at least 12 months.
   Results: We performed BCS in 151 sinuses, excluding 2 maxillary and 2 frontal sinuses. No major complication attributable to BCS was observed. After operation, suctioning and crust removal was not needed in the area operated oil in BCS patients. Revision surgery was needed in 2 patients after 6 months. From before to after operation, the SNOT-20 values and Lund-Mackay scores decreased significantly.
   Conclusions: We conclude that BCS helps to dilate the sinus ostia properly and effectively in the management of chronic rhinosinusitis. It can also be performed in the ethmoidal air cell area.
C1 [Kutluhan, Ahmet; Bozdemir, Kazim; Yalciner, Goekhan; Salviz, Mehti; Sari, Neslihan; Deger, Hasan Mervan; Bilgen, Akif Sinan] Ankara Ataturk Educ & Res Hosp, Dept Otorhinolaryngol, Ankara, Turkey.
   [Cetin, Hueseyin] Ankara Ataturk Educ & Res Hosp, Dept Radiol, Ankara, Turkey.
RP Bozdemir, K (reprint author), Ankara Ataturk Egitim & Arastirma Hastanesi, Bilkent Yolu 3, TR-06800 Cankaya, Turkey.
EM kazimbozdemir@gmail.com
CR Bolger WE, 2006, AM J RHINOL, V20, P290, DOI 10.2500/ajr.2006.20.2868
   Bolger WE, 2007, OTOLARYNG HEAD NECK, V137, P10, DOI 10.1016/j.otohns.2007.02.006
   Brown CL, 2006, ANN OTO RHINOL LARYN, V115, P293
   Chandra RK, 2007, OTOLARYNG HEAD NECK, V137, P953, DOI 10.1016/j.otohns.2007.09.002
   Church CA, 2008, OTOLARYNG HEAD NECK, V138, P187, DOI 10.1016/j.otohns.2007.10.014
   Friedman M, 2008, AM J RHINOL, V22, P204, DOI 10.2500/ajr.2008.22.3155
   Keerl R, 1999, LARYNGOSCOPE, V109, P546, DOI 10.1097/00005537-199904000-00005
   Kuhn FA, 2008, OTOLARYNG HEAD NECK, V139, pS27, DOI 10.1016/j.otohns.2008.05.010
   Levine HL, 2008, ANN OTO RHINOL LARYN, V117, P263
   MAY M, 1994, LARYNGOSCOPE, V104, P1080
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   Stamm A, 2009, OTOLARYNG HEAD NECK, V140, P320, DOI 10.1016/j.otohns.2008.11.034
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   Weiss RL, 2008, OTOLARYNG HEAD NECK, V139, pS38, DOI 10.1016/j.otohns.2008.06.008
NR 16
TC 10
Z9 10
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD DEC
PY 2009
VL 118
IS 12
BP 881
EP 886
PG 6
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 538EL
UT WOS:000273166900009
PM 20112523
ER

PT J
AU McRae, BR
   Kincaid, JC
   Illing, EA
   Hiatt, KK
   Hawkins, JF
   Halum, SL
AF McRae, Bryan R.
   Kincaid, John C.
   Illing, Elisa A.
   Hiatt, Kelly K.
   Hawkins, Jan F.
   Halum, Stacey L.
TI Local Neurotoxins for Prevention of Laryngeal Synkinesis After Recurrent
   Laryngeal Nerve Injury
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE larynx; recurrent laryngeal nerve; synkinesis; vincristine; vocal fold
   motion impairment; vocal fold paralysis
ID VOCAL FOLD PARALYSIS; CORD PARALYSIS; VINCRISTINE; RAT; REINNERVATION;
   REGENERATION; HEMILARYNX; CHILDREN; PHENOL; PALSY
AB Objectives: Persistent vocal fold motion impairment after recurrent laryngeal nerve (RLN) injury is not characteristically due to absent reinnervation, but often results from spontaneous aberrant reinnervation (synkinesis). We administered local neurotoxins to selected laryngeal muscles after RLN injury to determine whether aberrant reinnervation could be selectively inhibited.
   Methods: Unilateral RLN transection was performed in 24 male rats. Three weeks later, the denervated laryngeal adductor complex was injected with phenol, high- or low-dose vincristine sulfate (VNC), or saline solution. One month later, rat larynges were evaluated via videolaryngoscopy and laryngeal electromyography (LEMG). Larynges from euthanized animals were analyzed via immunofluorescent staining for the presence of reinnervation.
   Results: One animal that received phenol and 3 animals that received high-dose VNC died of toxicity-related complications. In the surviving neurotoxin-treated animals, videolaryngoscopy showed increased lateralization of the immobile vocal fold. Only I phenol-injected rat had adductor complex motor recruitment (score of 3+) with LEMG. The other neurotoxin-treated animals demonstrated an absence of adductor complex reinnervation, with only insertional activity and fibrillations (no motor units/recruitment). Spontaneous ipsilateral abductor reinnervatioll was not affected by the adductor injections.
   Conclusions: Low-dose VNC injections appear to be relatively safe and effective in selectively inhibiting spontaneous aberrant reinnervation after RLN injury in an animal model.
C1 [McRae, Bryan R.; Illing, Elisa A.; Hiatt, Kelly K.; Halum, Stacey L.] Indiana Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, Indianapolis, IN 46202 USA.
   [Kincaid, John C.] Indiana Univ, Sch Med, Dept Neurol, Indianapolis, IN 46202 USA.
   [Hawkins, Jan F.] Purdue Univ, Sch Vet Med, Dept Vet Clin Sci, W Lafayette, IN 47907 USA.
RP Halum, SL (reprint author), Indiana Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, 702 Barnhill Dr,Suite 860, Indianapolis, IN 46202 USA.
CR Ahmed A, 2007, PEDIATR BLOOD CANCER, V48, P248, DOI 10.1002/pbc.20850
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NR 31
TC 6
Z9 6
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD DEC
PY 2009
VL 118
IS 12
BP 887
EP 893
PG 7
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 538EL
UT WOS:000273166900010
PM 20112524
ER

PT J
AU Paniello, RC
   Edgar, JD
   Perlmutter, JS
AF Paniello, Randal C.
   Edgar, Julia D.
   Perlmutter, Joel S.
TI Vocal Exercise Versus Voice Rest Following Botulinum Toxin Injections: A
   Randomized Crossover Trial
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT 89th Annual Meeting of the American-Broncho-Esophagological-Association
CY MAY 28-29, 2009
CL Phoenix, AZ
SP Amer Broncho Esophagol Assoc
DE botulinum toxin; injection; quality of life; spasmodic dysphonia
ID ADDUCTOR SPASMODIC DYSPHONIA; LIFE V-RQOL; MUSCLE-ACTIVITY; QUALITY;
   SPASTICITY; DIFFUSION; VOLUME
AB Objectives: The intensity of muscle activity immediately following intramuscular botulinum toxin injection may affect the clinical efficacy of the injection. We tested this effect in patients who underwent botulinum toxin injections for adductor spasmodic dysphonia.
   Methods: Patients were studied over 3 to 5 injection cycles. Cycle 1 was the baseline control; cycle 2 was randomized between a 1-hour reading aloud task ("exercise") and a 24-hour period of complete voice rest. For cycle 3, the patient completed the task not performed in cycle 2. Patients who were willing to continue for cycles 4 and 5 repeated the experiment at one half the injection dosage. Efficacy was determined with a battery of voice recordings and clinical outcomes instruments administered via telephone at 2- to 4-week intervals. The primary outcome measure was the result of the Voice-Related Quality of Life (VRQOL) instrument.
   Results: Nine patients (8 women, I man) with a mean age of 60.8 years (range, 42 to 76 years) completed at least 3 injection cycles. The VRQOL results were significantly higher for cycles that followed the exercise task. The patients reported subjectively that these were some of the best injection cycles they had ever experienced. Some achieved equivalent results with the half-dose injection plus exercise. The VRQOL results after voice rest cycles were not significantly different from the patients' baseline cycles.
   Conclusions: These results support the conclusion that a period of intense vocalization immediately following laryngeal botulinum toxin injections improves the efficacy of the injection. Possible mechanisms are proposed.
C1 [Paniello, Randal C.; Edgar, Julia D.] Washington Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, St Louis, MO 63110 USA.
   [Perlmutter, Joel S.] Washington Univ, Sch Med, Dept Neurol, St Louis, MO 63110 USA.
   [Perlmutter, Joel S.] Washington Univ, Sch Med, Dept Radiol, St Louis, MO 63110 USA.
   [Perlmutter, Joel S.] Washington Univ, Sch Med, Dept Neurobiol, St Louis, MO 63110 USA.
   [Perlmutter, Joel S.] Washington Univ, Sch Med, Dept Occupat Therapy, St Louis, MO 63110 USA.
   [Perlmutter, Joel S.] Washington Univ, Sch Med, Dept Phys Therapy, St Louis, MO 63110 USA.
RP Paniello, RC (reprint author), Washington Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, 660 S Euclid Ave,CB 8115, St Louis, MO 63110 USA.
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NR 20
TC 2
Z9 3
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD NOV
PY 2009
VL 118
IS 11
BP 759
EP 763
PG 5
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 523YX
UT WOS:000272112100002
PM 19999359
ER

PT J
AU Huang, J
   Sacks, R
   Forer, M
AF Huang, Johnson
   Sacks, Raymond
   Forer, Martin
TI Endoscopic Resection of Juvenile Nasopharyngeal Angiofibroma
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT Meeting of the Australasian-Rhinologic-Society
CY SEP 26-28, 2008
CL Auckland, NEW ZEALAND
SP Australasian Rhinol Soc
DE angiofibroma; nasopharynx neoplasm; paranasal sinus neoplasm
ID PREOPERATIVE EMBOLIZATION; SURGERY
AB Objectives: A 2-surgeon technique has been proposed that allows resection of juvenile nasopharyngeal angiofibroma (JNA) with extension into the infratemporal fossa by utilizing a septal incision for passage of a retracting instrument from the opposite nostril. This technique, however, does not overcome the problem of limited space within the nasal cavity for the tumor to be retracted. Therefore, the tumor has to be divided to allow for its removal. We are proposing a different 2-surgeon technique as an alternative operative technique for the resection of JNA.
   Methods: A new technique of endoscopic resection of JNA involves a transseptal posterior perforation. This perforation allows retraction of the tumor into the opposite nasal cavity by the second surgeon. The retraction of the tumor creates space for its resection.
   Results: Nineteen patients (all male) underwent this 2-surgeon technique for resection of JNA. The follow-up period ranged up to 9 years, and no recurrence was recorded.
   Conclusions: Longer-term follow-up is needed to assess recurrence rate and morbidity with this technique. However, in our small series, the 2-surgeon technique via posterior septal perforation was associated with low morbidity and recurrence rates.
C1 [Huang, Johnson] Hornsby Hosp, Dept Ear Nose & Throat Surg, Hornsby, Australia.
   [Sacks, Raymond] Concord Gen Hosp, Dept Ear Nose & Throat Surg, Concord, Australia.
   [Forer, Martin] Royal N Shore Hosp, Dept Ear Nose & Throat Surg, St Leonards, NSW 2065, Australia.
RP Sacks, R (reprint author), Level 1,Suite 12,25-29 Hunter St, Hornsby, NSW 2077, Australia.
CR Andrade NA, 2007, OTOLARYNG HEAD NECK, V137, P492, DOI 10.1016/j.otohns.2007.03.003
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   Hofmann T, 2005, RHINOLOGY, V43, P282
   Li JR, 1998, EUR ARCH OTO-RHINO-L, V255, P430, DOI 10.1007/s004050050092
   Lloyd G, 1999, J LARYNGOL OTOL, V113, P127
   Newlands SD, 1999, AM J RHINOL, V13, P213, DOI 10.2500/105065899781389812
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   Robinson S, 2005, LARYNGOSCOPE, V115, P1818, DOI 10.1097/01.mlg.0000174956.90361.dc
   Schroth G, 1996, ARCH OTOLARYNGOL, V122, P1320
NR 9
TC 4
Z9 6
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD NOV
PY 2009
VL 118
IS 11
BP 764
EP 768
PG 5
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 523YX
UT WOS:000272112100003
PM 19999360
ER

PT J
AU Kim, JK
   Cho, JH
AF Kim, Jin Kook
   Cho, Jac Hoon
TI Change of External Auditory Canal pH in Acute Otitis Externa
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE acute otitis externa; pH
AB Objectives: We investigated 1) the correlation between the degree of acute otitis externa (AOE) and a change of pH and 2) the recovery of pH after acidification compared to an antibiotic otic solution in AOE. A change of pH in the external auditory canal (EAC) is very important for the pathogenesis of otitis externa. Therefore, not only an antibiotic otic solution, but also acidification, is known to be a good treatment for AOE. However, pH has only been investigated in chronic otitis externa, and not in AOE.
   Methods: This was a prospective randomized control study. Forty adult patients (56 ears) with AOE and 40 normal control Subjects (80 ears) participated in this Study. The severity of disease was graded as mild, moderate, or severe. The pH of each EAC was then measured. The patients were randomly assigned into 2 groups: one for vinegar irrigation and the other for topical antibiotics. The pH of the diseased ears was measured at I and 2 weeks after the treatment.
   Results: The mean (+/- SD) pH for the normal control subjects was 5.4 +/- 0.48, and the EAC lost its acidity proportionately to the degree of disease (p<0.05). For both the vinegar irrigation and topical antibiotic groups, the acidity was restored dramatically (p<0.05) at 1 and 2 weeks for the moderate and severe grades of otitis, but not for the mild grade. There was no difference in recovery between the 2 groups.
   Conclusions: The EAC lost its acidity proportionately to the degree of disease in AOE. Vinegar irrigation and topical antibiotics were equally effective for restoration of pH.
C1 [Kim, Jin Kook; Cho, Jac Hoon] Konkuk Univ, Coll Med, Dept Otorhinolaryngol Head & Neck Surg, Seoul 143729, South Korea.
RP Cho, JH (reprint author), Konkuk Univ, Coll Med, Dept Otorhinolaryngol Head & Neck Surg, 4-12 Hwayang Dong, Seoul 143729, South Korea.
FU Brain Korea 21 Project
FX From the Department of Otorhinolaryngology-Head and Neck Surgery,
   College of Medicine, Konkuk University, Seoul, Korea. This study was
   supported by the second phase of the Brain Korea 21 Project.
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NR 11
TC 4
Z9 4
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD NOV
PY 2009
VL 118
IS 11
BP 769
EP 772
PG 4
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 523YX
UT WOS:000272112100004
PM 19999361
ER

PT J
AU Sato, K
   Umeno, H
   Nakashima, T
   Nonaka, S
   Harabuchi, Y
AF Sato, Kiminori
   Umeno, Hirohito
   Nakashima, Tadashi
   Nonaka, Satoshi
   Harabuchi, Yasuaki
TI Expression and Distribution of Hyaluronic Acid and CD44 in Unphonated
   Human Vocal Fold Mucosa
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT 89th Annual Meeting of the American-Broncho-Esophagological-Association
CY MAY 28-29, 2009
CL Phoenix, AZ
SP Amer Broncho Esophagol Assoc
DE CD44; development; growth; hyaluronic acid; macula flava;
   mechanotransduction; vocal fold; vocal fold stellate cell
ID STORING STELLATE CELLS; AGE-RELATED-CHANGES; MACULA FLAVA; HUMAN
   NEWBORN; MECHANOTRANSDUCTION; BIOMECHANICS
AB Objectives: The tension caused by phonation (vocal fold vibration) is hypothesized to stimulate vocal fold stellate cells (VFSCs) in the maculae flavae (MFe) to accelerate production of extracellular matrices. The distribution of hyaluronic acid (HA) and expression of CD44 (a cell surface receptor for HA) were examined in human vocal fold mucosae (VFMe) that had remained unphonated since birth.
   Methods: Five specimens of VFMe (3 adults, 2 children) that had remained unphonated since birth were investigated with Alcian blue staining, hyaluronidase digestion, and immunohistochemistry for CD44.
   Results: The VFMe containing MFe were hypoplastic and rudimentary. The VFMe did not have a vocal ligament, Reinke's space, or a layered structure, and the lamina propria appeared as a uniform structure. In the children, HA was distributed in the VFMe containing MFe. In the adults, HA had decreased in the VFMe containing MFe. In both groups, the VFSCs in the MFe and the fibroblasts in the lamina propria expressed little CD44.
   Conclusions: This study supports the hypothesis that the tensions caused by vocal fold vibration stimulate the VFSCs in the MFe to accelerate production of extracellular matrices and form the layered structure. Phonation after birth is one of the important factors in the growth and development of the human VFMe.
C1 [Sato, Kiminori; Umeno, Hirohito; Nakashima, Tadashi] Kurume Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, Kurume, Fukuoka 8300011, Japan.
   [Nonaka, Satoshi; Harabuchi, Yasuaki] Asahikawa Med Coll, Dept Otolaryngol Head & Neck Surg, Asahikawa, Hokkaido 078, Japan.
RP Sato, K (reprint author), Kurume Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, 67 Asahi Machi, Kurume, Fukuoka 8300011, Japan.
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NR 25
TC 6
Z9 7
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD NOV
PY 2009
VL 118
IS 11
BP 773
EP 780
PG 8
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 523YX
UT WOS:000272112100005
PM 19999362
ER

PT J
AU Uwiera, TC
   de Alarcon, A
   Meinzen-Derr, J
   Cohen, AP
   Rasmussen, B
   Shott, G
   Greinwald, J
AF Uwiera, Trina C.
   de Alarcon, Alessandro
   Meinzen-Derr, Jareen
   Cohen, Aliza P.
   Rasmussen, Brian
   Shott, Gordon
   Greinwald, John
TI Hearing Loss Progression and Contralateral Involvement in Children With
   Unilateral Sensorineural Hearing Loss
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE hearing loss progression; new-onset hearing loss; unilateral
   sensorineural hearing loss
ID LARGE VESTIBULAR AQUEDUCT; PEDIATRIC POPULATION; COMPUTED-TOMOGRAPHY;
   CHILDHOOD; IMPAIRMENT
AB Objectives: We undertook this study to determine the rate of hearing loss progression in the affected ear of children with unilateral sensorineural hearing loss and without an enlarged vestibular aqueduct, and the rate of new-onset hearing loss in the contralateral ear.
   Methods: We searched the database at our pediatric tertiary care center to identify patients who met the inclusion criteria, examining demographic variables, audiometric data, and presumptive causes.
   Results: We identified 198 patients. At presentation, they showed slight left-sided and male predominances. Of 142 patients who had sufficient audiometric follow-up for us to evaluate progression, 21% showed ipsilateral progression and 10.6% developed new-onset hearing loss in the contralateral car. Isolated high-frequency loss was identified in 11 patients (5.6%), 8 of whom had sufficient follow-up for us to identify progression. Two showed progression; 4 others with progression in the ipsilateral ear developed new-onset high-frequency loss in the contralateral ear. Temporal bone anomalies were identified in 26 children (13%). and these children were more likely to have profound hearing loss than were those without temporal bone anomalies (46% versus 23%).
   Conclusions: The findings suggest that unilateral sensorineural hearing loss may not always be a unilateral process, but that it may be the initial manifestation of bilateral auditory dysfunction.
C1 [de Alarcon, Alessandro; Meinzen-Derr, Jareen; Cohen, Aliza P.; Rasmussen, Brian; Shott, Gordon; Greinwald, John] Cincinnati Childrens Hosp, Med Ctr, Ear & Hearing Ctr, Div Pediat Otolaryngol Head & Neck Surg, Cincinnati, OH 45229 USA.
   [Meinzen-Derr, Jareen] Cincinnati Childrens Hosp, Med Ctr, Div Biostat & Epidemiol, Cincinnati, OH 45229 USA.
   [Uwiera, Trina C.] Univ Alberta, Coll Med & Dent, Dept Surg, Div Pediat Otolaryngol Head & Neck Surg, Edmonton, AB, Canada.
   [Greinwald, John] Univ Cincinnati, Coll Med, Dept Otolaryngol Head & Neck Surg, Cincinnati, OH USA.
RP Greinwald, J (reprint author), Cincinnati Childrens Hosp, Med Ctr, Ear & Hearing Ctr, Div Pediat Otolaryngol Head & Neck Surg, 3333 Burnet Ave,MLC 2018, Cincinnati, OH 45229 USA.
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NR 22
TC 2
Z9 3
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD NOV
PY 2009
VL 118
IS 11
BP 781
EP 785
PG 5
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 523YX
UT WOS:000272112100006
PM 19999363
ER

PT J
AU Renukaswamy, GM
   Soma, MA
   Hartley, BEJ
AF Renukaswamy, Gayathri Mandya
   Soma, Marlene A.
   Hartley, Benjamin E. J.
TI Midline Cervical Cleft: A Rare Congenital Anomaly
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE cervical cleft; congenital cervical anomaly; congenital midline cleft;
   midline cervical cleft
ID NECK
AB Objectives: A midline cervical cleft (MCC) is a rare congenital anomaly due to failure of fusion of the first and second branchial arches during embryogenesis. It may present as a midline defect of the anterior neck skin with a skin projection or Sinus, or as a subcutaneous fibrous cord. This report evaluates the clinical features and surgical management of an MCC.
   Methods: We analyzed a series of 4 patients with an MCC successfully treated at Great Ormond Street Hospital for Children in London.
   Results: Three male patients and 1 female patient between 4 and 11 months of age were found to have an MCC. Each patient presented with an erythematous, fibrous band of tissue extending between the chin and the suprasternal notch. Treatment comprised surgical excision of the lesion and Z-plasty repair. We present the embryology, common clinical presentation, investigations, differential diagnosis, and histology, along with a literature review, of this uncommon malformation of the anterior neck.
   Conclusions: An MCC is a differential diagnosis to consider when assessing a child with a midline cervical lesion. Early Surgical excision with Z-plasty repair of the soft tissue defect is the treatment of choice to prevent long-term complications.
C1 [Renukaswamy, Gayathri Mandya; Soma, Marlene A.; Hartley, Benjamin E. J.] Great Ormond St Hosp Sick Children, Dept Paediat Otolaryngol, London WC1N 3JH, England.
RP Renukaswamy, GM (reprint author), 191 Whitby House,Marton Pk, Middlesbrough TS4 3GG, Cleveland, England.
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NR 26
TC 2
Z9 2
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD NOV
PY 2009
VL 118
IS 11
BP 786
EP 790
PG 5
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 523YX
UT WOS:000272112100007
PM 19999364
ER

PT J
AU Berkowitz, RG
   Ryan, MM
   Pilowsky, PM
AF Berkowitz, Robert G.
   Ryan, Monique M.
   Pilowsky, Paul M.
TI Respiration-Related Laryngeal Electromyography in Children With
   Bilateral Vocal Fold Paralysis
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT 89th Annual Meeting of the American-Broncho-Esophagological-Association
CY MAY 28-29, 2009
CL Phoenix, AZ
SP Amer Broncho Esophagol Assoc
DE electromyography; larynx; synkinesis
ID CORD PARALYSIS; RAT; MOTONEURONS; SYNKINESIS
AB We present 2 case reports to demonstrate the relationship between laryngeal muscle activity and respiration in children with bilateral vocal fold paralysis (BVFP) by simultaneous laryngeal electromyography (EMG) with recording of chest wall movement and intercostal muscle EMG. Laryngeal EMG was performed together with recording of chest wall movement in a 55-day-old girl who was undergoing tracheostomy for idiopathic congenital BVFP. Normal phasic activity was observed, ie, the thyroarytenoid (TA) muscle was active during expiration and the posterior cricoarytenoid (PCA) muscle during inspiration, suggesting a good prognosis for recovery. The child was decannulated at 11 months. Laryngeal EMG to-ether with recording of chest wall movement and intercostal EMG in a 5-year-old girl who was tracheostomy-dependent following tracheoesophageal fistula repair due to BVFP showed phasic activity during expiration for both the TA and PCA muscles, indicating aberrant regeneration of the PCA motor nerve. The timing of laryngeal muscle activity with respiration in the assessment of pediatric congenital BVFP is essential to demonstrate the presence of normal or abnormal medullary respiratory neuronal input to laryngeal motoneurons. In cases in which BVFP is due to recurrent laryngeal nerve injury, respiration-related laryngeal EMG will identify aberrant regeneration. Laryngeal EMG should be combined with intercostal muscle EMG in the evaluation of children with significant vocal fold dysfunction of either central or peripheral origin.
C1 [Berkowitz, Robert G.] Royal Childrens Hosp, Dept Otolaryngol, Melbourne, Vic, Australia.
   [Ryan, Monique M.] Royal Childrens Hosp, Dept Neurosci, Melbourne, Vic, Australia.
   Murdoch Childrens Res Inst, Melbourne, Vic, Australia.
   [Berkowitz, Robert G.; Pilowsky, Paul M.] Macquarie Univ, Australian Sch Adv Med, Sydney, NSW 2109, Australia.
RP Berkowitz, RG (reprint author), Royal Childrens Hosp, Dept Otolaryngol, Flemington Rd, Parkville, Vic 3052, Australia.
RI Pilowsky, Paul/G-7514-2011
CR Berkowitz RG, 1996, ANN OTO RHINOL LARYN, V105, P207
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NR 13
TC 6
Z9 7
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD NOV
PY 2009
VL 118
IS 11
BP 791
EP 795
PG 5
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 523YX
UT WOS:000272112100008
PM 19999365
ER

PT J
AU Okano, W
   Nomoto, Y
   Wada, I
   Kobayashi, K
   Miyake, M
   Nakamura, T
   Omori, K
AF Okano, Wataru
   Nomoto, Yukio
   Wada, Ikuo
   Kobayashi, Ken
   Miyake, Masao
   Nakamura, Tatsuo
   Omori, Koichi
TI Bioengineered Trachea With Fibroblasts in a Rabbit Model
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT 89th Annual Meeting of the American-Broncho-Esophagological-Association
CY MAY 28-29, 2009
CL Phoenix, AZ
SP Amer Broncho Esophagol Assoc
DE fibroblast; regeneration; trachea
ID HUMAN KERATINOCYTE GROWTH; EPITHELIAL REGENERATION; IN-VITRO; CELLS;
   RECONSTRUCTION; SCAFFOLD; SURFACE
AB Objectives: Although our group has had mostly successful results with clinical application of a tracheal prosthesis, delayed epithelial regeneration remains a problem. In our previous studies using rats, it was demonstrated that tracheal fibroblasts accelerated proliferation and differentiation of the tracheal epithelium in vitro and in vivo. The purpose of this study was to evaluate the effects of fibroblasts on epithelial regeneration in larger tracheal defects in rabbits.
   Methods: We developed a bioengineered scaffold, the luminal surface of which was coated with fibroblasts. This scaffold was implanted into tracheal defects in 12 rabbits (bioengineered group), and scaffolds without fibroblasts were implanted in 12 rabbits (control group). The regenerated epithelium was histologically examined by light microscopy, scanning electron microscopy, and immunohistochemical studies.
   Results: In the bioengineered group, a stratified squamous epithelium was observed on the surface 7 days after transplantation. However, in the control group, the scaffolds were exposed. Fourteen days after implantation, a columnar ciliated epithelium was observed in the bioengineered group. The average thickness of the regenerated epithelium in the bioengineered group was significantly greater than that in the control group.
   Conclusions: This study indicated that fibroblasts had a stimulatory effect that hastened regeneration of the epithelium in large tracheal defects.
C1 [Okano, Wataru; Nomoto, Yukio; Omori, Koichi] Fukushima Med Univ, Sch Med, Dept Otolaryngol, Fukushima 9601295, Japan.
   [Wada, Ikuo] Fukushima Med Univ, Sch Med, Dept Cell Sci, Inst Biomed Sci, Fukushima 9601295, Japan.
   [Miyake, Masao] Fukushima Med Univ, Sch Med, Dept Physiol 1, Fukushima 9601295, Japan.
   [Kobayashi, Ken] Keio Univ, Sch Med, Dept Pharmacol, Tokyo 160, Japan.
   [Nakamura, Tatsuo] Kyoto Univ, Inst Frontier Med Sci, Dept Bioartificial Organs, Kyoto, Japan.
RP Okano, W (reprint author), Fukushima Med Univ, Sch Med, Dept Otolaryngol, 1 Hikarigaoka, Fukushima 9601295, Japan.
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NR 19
TC 10
Z9 10
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD NOV
PY 2009
VL 118
IS 11
BP 796
EP 804
PG 9
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 523YX
UT WOS:000272112100009
PM 19999366
ER

PT J
AU Ohno, S
   Hirano, S
   Tateya, I
   Kanemaru, SI
   Umeda, H
   Suehiro, A
   Kitani, Y
   Kishimoto, Y
   Kojima, T
   Nakamura, T
   Ito, J
AF Ohno, Satoshi
   Hirano, Shigeru
   Tateya, Ichiro
   Kanemaru, Shin-ichi
   Umeda, Hiroo
   Suehiro, Atsushi
   Kitani, Yoshiharu
   Kishimoto, Yo
   Kojima, Tsuyoshi
   Nakamura, Tatsuo
   Ito, Juichi
TI Atelocollagen Sponge as a Stem Cell Implantation Scaffold for the
   Treatment of Scarred Vocal Folds
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT 89th Annual Meeting of the American-Broncho-Esophagological-Association
CY MAY 28-29, 2009
CL Phoenix, AZ
SP Amer Broncho Esophagol Assoc
DE atelocollagen; bone marrow-derived stromal cell; cell implantation;
   mesenchymal stem cell; scaffold
ID BONE-MARROW; GROWTH-FACTOR; STROMAL CELLS; CANINE MODEL
AB Objectives: Treatment of vocal fold scarring remains a therapeutic challenge. Our group previously reported the efficacy of treating injured vocal folds by implantation of bone marrow-derived stromal cells containing mesenchymal stern cells. Appropriate scaffolding is necessary for the stem cell implant to achieve optimal results. Terudermis is an atelocollagen sponge derived from calf dermis. It has large pores that permit cellular entry and is degraded in vivo. These characteristics suggest that this material may be a good candidate for use as scaffolding for implantation of cells. The present in vitro Study investigated the feasibility of using Terudermis as such a scaffold.
   Methods: Bone marrow-derived stromal cells were obtained from GFP (green fluorescent protein) mouse femurs. The cells were seeded into Terudermis and incubated for 5 days. Their survival, proliferation, and expression of extracellular matrix were examined.
   Results: Bone marrow-derived stromal cells adhered to Terudermis and underwent significant proliferation. Immunohistochemical examination demonstrated that adherent cells were positive for expression of vimentin, desmin, fibronectin, and fsp1 and negative for beta III tubulin. These findings indicate that these cells were mesodermal cells and attached to the atelocollagen fibers biologically.
   Conclusions: The data suggest that Terudermis may have potential as stein cell implantation scaffolding for the treatment of scarred vocal folds.
C1 [Ohno, Satoshi; Hirano, Shigeru; Tateya, Ichiro; Kanemaru, Shin-ichi; Umeda, Hiroo; Suehiro, Atsushi; Kitani, Yoshiharu; Kishimoto, Yo; Kojima, Tsuyoshi; Ito, Juichi] Kyoto Univ, Grad Sch Med, Dept Otolaryngol Head & Neck Surg, Sakyo Ku, Kyoto 6068507, Japan.
   [Nakamura, Tatsuo] Kyoto Univ, Inst Frontier Med Sci, Dept Bioartificial Organs, Kyoto 6068507, Japan.
RP Ohno, S (reprint author), Kyoto Univ, Grad Sch Med, Dept Otolaryngol Head & Neck Surg, Sakyo Ku, Kyoto 6068507, Japan.
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NR 16
TC 11
Z9 13
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD NOV
PY 2009
VL 118
IS 11
BP 805
EP 810
PG 6
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 523YX
UT WOS:000272112100010
PM 19999367
ER

PT J
AU Purkey, MT
   Levine, MS
   Prendes, B
   Norman, MF
   Mirza, N
AF Purkey, Michael T.
   Levine, Marc S.
   Prendes, Brandon
   Norman, M. Frank
   Mirza, Natasha
TI Predictors of Aspiration Pneumonia Following Radiotherapy for Head and
   Neck Cancer
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT 89th Annual Meeting of the American-Broncho-Esophagological-Association
CY MAY 28-29, 2009
CL Phoenix, AZ
SP Amer Broncho Esophagol Assoc
DE aspiration; head and neck cancer; irradiation; pneumonia
ID MODIFIED BARIUM SWALLOW; SQUAMOUS-CELL HEAD; CONCURRENT CHEMOTHERAPY;
   ORGAN PRESERVATION; RADIATION-THERAPY; DYSPHAGIA; CHEMORADIATION;
   DYSFUNCTION; CARCINOMA
AB Objectives: Aspiration following radiotherapy for head and neck cancer (HNC) is a common event, but not all patients with aspiration will develop pneumonia. Our aim was to identify predictors of pneumonia in patients with aspiration following radiotherapy for HNC.
   Methods: We performed a retrospective study of 52 patients referred for modified videofluoroscopic barium swallow (MVBS) testing at our institution from 2003 to 2007 in order to identify clinical variables associated with the diagnosis of aspiration pneumonia.
   Results: Independent risk factors for the development of pneumonia were tracheobronchial aspiration on MVBS testing (odds ratio [OR], 5.0; 95% confidence interval [CI], 1.2 to 20.5; p = 0.025), malnutrition (OR, 4.4; 95% CI, 1.3 to 14.7; p = 0.018). and smoking history (OR, 1.04 per pack-year; 95% CI, 1.01 to 1.07 p = 0.011). Through logistic regression analysis. we developed a bivariate predictive model with a sensitivity of 58%, a specificity of 90%, a positive predictive value of 79%, and a negative predictive value of 77% for the development of aspiration pneumonia in our patient population.
   Conclusions: Depth of aspiration on MVBS testing, malnutrition, and smoking history were strongly associated with the development of aspiration pneumonia in our patient population. The use of clinical variables to determine the risk of aspiration pneumonia is feasible and may help identify high-risk patients.
C1 [Purkey, Michael T.; Levine, Marc S.; Prendes, Brandon; Norman, M. Frank; Mirza, Natasha] Hosp Univ Penn, Dept Otorhinolaryngol Head & Neck Surg, Philadelphia, PA 19104 USA.
RP Mirza, N (reprint author), Hosp Univ Penn, Dept Otorhinolaryngol Head & Neck Surg, 3400 Spruce St,5 Silverstein, Philadelphia, PA 19104 USA.
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NR 24
TC 5
Z9 5
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD NOV
PY 2009
VL 118
IS 11
BP 811
EP 816
PG 6
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 523YX
UT WOS:000272112100011
PM 19999368
ER

PT J
AU Mcgee, S
   Mardirossian, V
   Elackattu, A
   Mirkovic, J
   Pistey, R
   Gallagher, G
   Kabani, S
   Yu, CC
   Wang, Z
   Badizadegan, K
   Grillone, G
   Feld, MS
AF McGee, Sasha
   Mardirossian, Vartan
   Elackattu, Alphi
   Mirkovic, Jelena
   Pistey, Robert
   Gallagher, George
   Kabani, Sadru
   Yu, Chung-Chieh
   Wang, Zimmern
   Badizadegan, Kamran
   Grillone, Gregory
   Feld, Michael S.
TI Anatomy-Based Algorithms for Detecting Oral Cancer Using Reflectance and
   Fluorescence Spectroscopy
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE diagnosis; fluorescence; oral cancer; reflectance; spectroscopy
ID NATIVE CELLULAR FLUORESCENCE; AERODIGESTIVE TRACT CANCER; IN-VIVO;
   AUTOFLUORESCENCE SPECTROSCOPY; EXCITATION WAVELENGTHS; OPTICAL
   SPECTROSCOPY; INCISIONAL BIOPSY; LIGHT-SCATTERING; DIAGNOSIS; LESIONS
AB Objectives: We used reflectance and fluorescence spectroscopy to noninvasively and quantitatively distinguish benign from dysplastic/malignant oral lesions. We designed diagnostic algorithms to account for differences in the spectral properties among anatomic sites (gingiva, buccal mucosa, etc).
   Methods: In vivo reflectance and fluorescence spectra were collected from 71 patients with oral lesions. The tissue was then biopsied and the specimen evaluated by histopathology. Quantitative parameters related to tissue morphology and biochemistry were extracted from the spectra. Diagnostic algorithms specific for combinations of sites with similar spectral properties were developed.
   Results: Discrimination of benign from dysplastic/malignant lesions was most successful when algorithms were designed for individual sites (area under the receiver operator characteristic curve [ROC-AUC], 0.75 for the lateral surface of the tongue) and was least accurate when all sites were combined (ROC-AUC, 0.60). The combination of sites with similar spectral properties (floor of mouth and lateral surface of the ton-Lie) yielded an ROC-AUC of 0.71.
   Conclusions: Accurate spectroscopic detection of oral disease must account for spectral variations among anatomic sites. Anatomy-based algorithms for single sites or combinations of sites demonstrated good diagnostic performance in distinguishing benign lesions from dysplastic/malignant lesions and consistently performed better than algorithms developed for all sites combined.
C1 [Mardirossian, Vartan; Elackattu, Alphi; Wang, Zimmern; Grillone, Gregory] Boston Med Ctr, Dept Otolaryngol Head & Neck Surg, Boston, MA USA.
   [Pistey, Robert] Boston Med Ctr, Dept Anat Pathol, Boston, MA USA.
   [McGee, Sasha; Mirkovic, Jelena; Yu, Chung-Chieh; Badizadegan, Kamran; Feld, Michael S.] MIT, GR Harrison Spect Lab, Boston, MA USA.
   [Gallagher, George; Kabani, Sadru] Boston Univ, Goldman Sch Dent Med, Dept Oral & Maxillofacial Pathol, Boston, MA 02215 USA.
   [Badizadegan, Kamran] Harvard Univ, Sch Med, Dept Pathol, Boston, MA 02115 USA.
   [Badizadegan, Kamran] Massachusetts Gen Hosp, Boston, MA 02114 USA.
RP Mcgee, S (reprint author), MIT, GR Harrison Spect Lab, Bldg 6-205,77 Massachusetts Ave, Cambridge, MA 02139 USA.
RI Mirkovic, Jelena/A-6253-2013
FU National Institutes of Health [R01-CA097966, P41-RR02594-21]
FX From the G. R. Harrison Spectroscopy Laboratory, Massachusetts Institute
   of Technology (McGee, Mirkovic, Yu, Badizadegan, Feld), the Departments
   of Otolaryngology-Head and Neck Surgery (Mardirossian, Elackattu, Wang,
   Grillone) and Anatomic Pathology (Pistey), Boston Medical Center, the
   Department of Oral and Maxillofacial Pathology, Boston University
   Goldman School of Dental Medicine (Gallagher, Kabani), and the
   Department of Pathology, Harvard Medical School and Massachusetts
   General Hospital (Badizadegan), Boston. Massachusetts. This research was
   supported by National Institutes of Health grants R01-CA097966 and
   P41-RR02594-21.
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NR 44
TC 16
Z9 16
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD NOV
PY 2009
VL 118
IS 11
BP 817
EP 826
PG 10
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 523YX
UT WOS:000272112100012
PM 19999369
ER

PT J
AU Oyer, SL
   Anderson, LC
   Halum, SL
AF Oyer, Samuel L.
   Anderson, Lauren C.
   Halum, Stacey L.
TI Influence of Anxiety and Depression on the Predictive Value of the
   Reflux Symptom Index
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT 89th Annual Meeting of the American-Broncho-Esophagological-Association
CY MAY 28-29, 2009
CL Phoenix, AZ
SP Amer Broncho Esophagol Assoc
DE extra-esophageal reflux; laryngopharyngeal reflux; psychiatric disorder;
   reflux; Reflux Finding Score; Reflux Symptom Index
ID QUALITY-OF-LIFE; LARYNGOPHARYNGEAL REFLUX; GASTROESOPHAGEAL-REFLUX;
   FINDING SCORE; RELIABILITY; DISEASE; PROBE; VALIDITY; SPEECH
AB Objectives: Although the Reflux Symptom Index (RSI) is a validated laryngopharyngeal reflux (LPR) outcomes tool, its predictive value for LPR is controversial. Because psychiatric problems may lead to exaggerated patient-perceived symptoms and RSI values, the aim of this Study was to determine whether the positive predictive value of the RSI for pH probe-documented LPR is influenced by anxiety and depression.
   Methods: We reviewed the charts of all patients who underwent pH probe testing for LPR between January 2006 and July 2008 at our institution. The RSI, Reflux Finding Score (RFS), medical history, and pH probe findings were recorded. Patients with anxiety or depression were included in the psychiatric disorder (+PSY) group, and those without anxiety or depression comprised the non-psychiatric disorder (-PSY) group. Predictive values of the RSI for pH probe-documented LPR were determined for each group.
   Results: We included 51 patients: 30 patients (59%) in the -PSY group and 21 patients (41%) in the +PSY group. The mean RSI of the +PSY group was higher than that of the -PSY group (p < 0.05). but the +PSY patients actually had a lower incidence of abnormal probe studies (p < 0.02). The positive predictive value of an elevated RSI for an abnormal pH probe study was poor in the +PSY patients (p = 0.495), but strong in the -PSY group (p = 0.004).
   Conclusions: The presence of anxiety and depression impairs the predictive value of the RSI for LPR. This finding potentially explains some of the controversy over the diagnostic utility of the RSI.
C1 [Oyer, Samuel L.; Anderson, Lauren C.; Halum, Stacey L.] Indiana Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, Indianapolis, IN 46202 USA.
RP Halum, SL (reprint author), Indiana Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, 950 W Walnut St,Res 11 Bldg,Room E443, Indianapolis, IN 46202 USA.
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NR 21
TC 8
Z9 9
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD OCT
PY 2009
VL 118
IS 10
BP 687
EP 692
PG 6
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 509UZ
UT WOS:000271045500001
PM 19894394
ER

PT J
AU Verhaegen, VJO
   Mulder, JJS
   Mylanus, EAM
   Cremers, CWRJ
   Snik, AFM
AF Verhaegen, Veronique J. O.
   Mulder, Jef J. S.
   Mylanus, Emmanuel A. M.
   Cremers, Cor W. R. J.
   Snik, Ad F. M.
TI Profound Mixed Hearing Loss: Bone-Anchored Hearing Aid System or
   Cochlear Implant?
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE bone-anchored hearing aid; cochlear implant; indication criterion;
   profound mixed hearing loss
ID SUPPURATIVE OTITIS-MEDIA; EXPERIENCE
AB Objectives: We evaluated 5 patients who were changed over from a Baha Cordelle to a cochlear implant (CI). Moreover, the level of phoneme score was determined at which a Baha Cordelle user was better helped with a CI.
   Methods: We offer descriptive case reports and a retrospective evaluation of speech recognition in Baha Cordelle users and CI users.
   Results: In the CI users with noncompromised cochleas, the 10th percentile of the aided phoneme score in quiet at 65 dB sound pressure level (PS65) was 42%. We consider this PS65 as the cutoff level for switching from a Baha Cordelle to a CI. When patients with mixed hearing loss were using the Baha Cordelle, the PS65 of 42% was obtained at a mean sensorineural hearing loss component of about 70 dB hearing level (HL). This 70-dB HL component was used to consider Baha Cordelle users for cochlear implantation. The results of the 5 patients support these transition criteria.
   Conclusions: A CI is a valuable option in patients with mixed hearing loss when the sensorineural hearing loss component exceeds 70 dB HL or when the PS65 with a Baha Cordelle is less than about 40%. In such patients, the implantation procedure should be individualized on the basis of the clinical findings in the middle ear and mastoid cavity.
C1 [Verhaegen, Veronique J. O.; Mulder, Jef J. S.; Mylanus, Emmanuel A. M.; Cremers, Cor W. R. J.; Snik, Ad F. M.] Radboud Univ Nijmegen, Med Ctr Nijmegen, Dept Otorhinolaryngol, NL-6500 HB Nijmegen, Netherlands.
RP Verhaegen, VJO (reprint author), Radboud Univ Nijmegen, Med Ctr Nijmegen, Dept Otorhinolaryngol, POB 9101, NL-6500 HB Nijmegen, Netherlands.
RI Mylanus, Emmanuel/D-2255-2010; Snik, Ad/H-8092-2014
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NR 14
TC 4
Z9 5
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD OCT
PY 2009
VL 118
IS 10
BP 693
EP 697
PG 5
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 509UZ
UT WOS:000271045500002
PM 19894395
ER

PT J
AU Nguyen, CV
   Parikh, SR
   Bent, JP
AF Nguyen, Carolyn V.
   Parikh, Sanjay R.
   Bent, John P.
TI Comparison of Intraoperative Bleeding Between Microdebrider
   Intracapsular Tonsillectomy and Electrocautery Tonsillectomy
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT 23rd Annual Meeting of the American-Society-of-Pediatric-Otolaryngology
CY MAY 02-04, 2008
CL Orlando, FL
SP Amer Soc Pediat Otolaryngol
DE electrocautery tonsillectomy; intracapsular tonsillectomy; microdebrider
   tonsillectomy; obstructive sleep apnea; surgical blood loss; tonsillar
   hypertrophy
ID CHILDREN; ADENOIDECTOMY; ADENOTONSILLECTOMY; COMPLICATIONS; SAFETY
AB Objectives: We sought to assess the quantity of intraoperative bleeding from microdebrider intracapsular tonsillectomy (IT) relative to electrocautery tonsillectomy (ET).
   Methods: Intraoperative tonsil bleeding was measured prospectively for all children younger than 19 years of age who underwent primary tonsillectomy for recurrent tonsillitis or adenotonsillar hypertrophy at a tertiary care academic children's hospital. We performed IT in 57 patients (33 male, 24 female; mean age, 64.3 months) and ET in 51 patients (20 male, 31 female; mean age, 92.4 months).
   Results: Microdebrider IT resulted in more intraoperative bleeding than ET (27.9 versus 8.7 mL, p = 0.003; and 1.2 versus 0.2 mL/ka, p < 0.001). The median and maximum blood losses, respectively, were 0.6 and 9.5 mL/kg for IT and 0 and 2.0 mL/kg for ET. Blood loss for ET was not related to whether a resident versus an attending physician was the operating surgeon (p = 0.11). A linear regression model did not demonstrate greater bleeding with recurrent tonsillitis (IT, p 0.39; ET, p = 0.89) or with increased patient age (IT, p = 0.08; ET, p = 0.62).
   Conclusions: Microdebrider IT produces more intraoperative bleeding than ET. The difference in blood loss is statistically but not clinically significant. Microdebrider IT causes bleeding within acceptable limits, and thus patients and physicians should not be discouraged from choosing this procedure solely on the basis of the amount of intraoperative blood loss.
C1 [Nguyen, Carolyn V.; Parikh, Sanjay R.; Bent, John P.] Albert Einstein Coll Med, Childrens Hosp Montefiore, Dept Otorhinolaryngol Head & Neck Surg, Bronx, NY 10467 USA.
RP Nguyen, CV (reprint author), Albert Einstein Coll Med, Childrens Hosp Montefiore, Dept Otorhinolaryngol Head & Neck Surg, 3400 Bainbridge Ave,3rd Floor, Bronx, NY 10467 USA.
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NR 19
TC 10
Z9 11
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD OCT
PY 2009
VL 118
IS 10
BP 698
EP 702
PG 5
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 509UZ
UT WOS:000271045500003
PM 19894396
ER

PT J
AU Lin, HW
   Quesnel, AM
   Holman, AS
   Curry, WT
   Rho, MB
AF Lin, Harrison W.
   Quesnel, Alicia M.
   Holman, Allison S.
   Curry, William T., Jr.
   Rho, Michael B.
TI Hypertrophic Anterior Cervical Osteophytes Causing Dysphagia and Airway
   Obstruction
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE airway obstruction; anterior cervical osteophyte; dysphagia
ID IDIOPATHIC SKELETAL HYPEROSTOSIS; FORESTIERS-DISEASE; DISH;
   MANIFESTATIONS; DYSPNEA
AB Hyperostosis of anterior cervical vertebral osteophytes can produce otolaryngological symptoms ranging from mild dysphagia, dysphonia, and foreign body sensation to severe food impaction and stridulous dyspnea. Airway compromise necessitating a tracheostomy is very rare. We discuss the case of an elderly man who presented with progressive dysphagia and a large hypopharyngeal mass as his initial manifestations of hypertrophic anterior cervical osteophytes. After a biopsy of the mass, the patient went into airway distress due to bilateral vocal fold fixation by the enlarging mass and consequently required a surgical airway. A combined team approach to the removal of the osteophytes successfully resolved his symptoms. The clinical, diagnostic, radiologic, and therapeutic principles involved in this case are presented and discussed. The recognition of hypertrophic osteophytes as a potential cause of common otolaryngological symptoms in the elderly population is paramount, as these symptoms can rapidly progress and lead to life-threatening airway obstruction. Medical and surgical interventions can be employed for the treatment of hypertrophic anterior cervical osteophytes, and they often result in favorable outcomes.
C1 [Lin, Harrison W.; Quesnel, Alicia M.; Rho, Michael B.] Massachusetts Eye & Ear Infirm, Dept Otolaryngol, Boston, MA 02114 USA.
   [Lin, Harrison W.; Quesnel, Alicia M.; Rho, Michael B.] Harvard Univ, Sch Med, Dept Otol & Laryngol, Boston, MA 02115 USA.
   [Holman, Allison S.] Massachusetts Gen Hosp, Dept Speech Language & Swallowing Disorders, Boston, MA 02114 USA.
   [Curry, William T., Jr.] Massachusetts Gen Hosp, Dept Neurosurg, Boston, MA 02114 USA.
RP Lin, HW (reprint author), Massachusetts Eye & Ear Infirm, Dept Otolaryngol, 243 Charles St, Boston, MA 02114 USA.
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   Nelson RS, 2006, J AM COLL SURGEONS, V202, P938, DOI 10.1016/j.jamcollsurg.2006.02.030
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   RESNICK D, 1982, DIAGNOSIS BONE JOINT, P1562
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NR 22
TC 7
Z9 7
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD OCT
PY 2009
VL 118
IS 10
BP 703
EP 707
PG 5
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 509UZ
UT WOS:000271045500004
PM 19894397
ER

PT J
AU Melroy, CT
   Kuhn, FA
AF Melroy, Christopher T.
   Kuhn, Frederick A.
TI Safety of Ethmoid Sinus Drug-Eluting Catheter Insertion
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT 112th Annual Meeting of the
   American-Academy-of-Otolaryngology-Head-and-Neck-Surgery
CY SEP 21-24, 2008
CL Chicago, IL
SP Amer Acad Otolaryngol Head & Neck Surg
DE chronic ethmoid sinusitis; chronic rhinosinusitis; device safety;
   drug-eluting catheter; minimally invasive procedure; topical therapy
ID SURGERY
AB Objectives: We sought to evaluate an instrument that allows a drug-eluting catheter to be inserted into the ethmoid sinuses and to demonstrate its safety and reproducibility in a cadaver model.
   Methods: A drug-eluting catheter was placed into 12 cadaveric anterior and posterior ethmoid sinuses by use of a trocar-based insertion device. The device's position was analyzed with computed tomographic scans, and postprocedural dissection was performed.
   Results: The drug-eluting catheter system was successfully inserted in all ethmoid sinuses without injury to the medial orbital wall, skull base, or sphenoid face. The final position of the distal tip of the catheter averaged 8.1 mm (root mean square [RMS], 3.3 mm) from the skull base, 5.6 mm (RMS, 3.5 mm) from the sphenoid face, and 5.0 mm (RMS, 3.5 mm) from the lamina papyracea; the proximal tip was at the face of the ethmoid bulla and 17.1 mm (RMS, 3.5 mm) below the skull base.
   Conclusions: A trocar-based instrument can relatively safely and reproducibly introduce a drug-eluting catheter into the ethmoid sinuses without injuring the skull base, lamina papyracea, or sphenoid face. This device may allow safe topical drug delivery into the ethmoid sinuses and serve as a vehicle to treat chronic ethmoid sinusitis with direct and sustained topical therapy.
C1 [Melroy, Christopher T.; Kuhn, Frederick A.] Georgia Nasal & Sinus Inst, Savannah, GA 31404 USA.
RP Melroy, CT (reprint author), Georgia Nasal & Sinus Inst, 4750 Waters Ave,Suite 112, Savannah, GA 31404 USA.
CR KENNEDY DW, 1985, ARCH OTOLARYNGOL, V111, P576
   Lang J., 1989, CLIN ANATOMY NOSE NA, P56
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   WIGAND WE, 1990, ENDOSCOPIC SURG PARA
NR 6
TC 4
Z9 4
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD OCT
PY 2009
VL 118
IS 10
BP 708
EP 713
PG 6
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 509UZ
UT WOS:000271045500005
PM 19894398
ER

PT J
AU Mullin, D
   Jothi, S
   Healy, D
AF Mullin, David
   Jothi, Sumana
   Healy, David
TI Mycobacterium chelonae Infections Involving the Head and Neck
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE atypical mycobacterium; Mycobacterium chelonae; osteomyelitis
ID SKULL BASE OSTEOMYELITIS; SOFT-TISSUE; MASTOIDITIS; ABSCESSUS; THERAPY;
   BONE
AB Objectives: We describe the manifestations, diagnosis, and treatment of rare head and neck infections caused by Mycobacterium chelonae, including a case of maxillary osteitis and skull base osteomyelitis.
   Methods: A comprehensive literature search (MEDLINE from 195 1; BIOSIS from 1969; EMBASE from 1980) was performed formed for the presentation, diagnostic evaluation, and outcomes of patients with M chelonae infections.
   Results: We report 4 cases of M chelonae infection, including a nasal abscess following septorhinoplasty with a cartilaginous graft, a case of chronic unilateral nasal obstruction, and the first reported cases of skull base osteomyelitis and maxillary osteitis secondary to M chelonae. All 4 cases involved immunocompetent individuals.
   Conclusions: Mycobacterium chelonae should be considered in cases of abscesses that persist despite broad-spectrum intravenous antibiotics, and in cases of maxillary sinusitis with bony involvement that do not respond to traditional treatment methods.
C1 [Mullin, David; Healy, David] USN, San Diego Med Ctr, Dept Otolaryngol, San Diego, CA 92134 USA.
   [Jothi, Sumana] Univ Calif San Diego, Dept Otolaryngol, San Diego, CA 92103 USA.
RP Mullin, D (reprint author), USN, San Diego Med Ctr, Dept Otolaryngol, 34520 Bob Wilson Dr,Suite 200, San Diego, CA 92134 USA.
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NR 30
TC 3
Z9 3
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD OCT
PY 2009
VL 118
IS 10
BP 714
EP 720
PG 7
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 509UZ
UT WOS:000271045500006
PM 19894399
ER

PT J
AU Lee, HM
   Kang, HJ
   Park, HH
   Hong, SC
   Kim, JK
   Cho, JH
AF Lee, Heung-Man
   Kang, Hee Jun
   Park, Hyo Hun
   Hong, Seok-Chan
   Kim, Jin-Kook
   Cho, Jae Hoon
TI Effect of Peroxisome Proliferator-Activated Receptor Gamma Agonists on
   Myofibroblast Differentiation and Collagen Production in Nasal
   Polyp-Derived Fibroblasts
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE fibroblast; nasal polyp; peroxisome proliferator-activated receptor
   gamma agonist
ID GROWTH-FACTOR-BETA; PPAR-GAMMA; ALPHA; LUNG; PATHOGENESIS; INFLAMMATION;
   TGF-BETA-1; ATTENUATE; FIBROSIS; DISEASES
AB Objectives: We investigated the effect of transforming growth factor-beta 1 (TGF-beta 1) on the differentiation of nasal polyp-derived Fibroblasts (NPDFs) and on their production of collagen, and investigated the effect of peroxisome proliferator-activated receptor gamma (PPAR gamma) agonists on the effects of TGF-beta 1.
   Methods: Primary fibroblast lines were established from 5 human nasal polyp tissues. We activated the NPDFs with TGF-beta 1 and exposed them to the PPAR gamma agonists ciglitazone and 15-deoxy-Delta-prostaglandin J2. The expression of alpha-smooth muscle actin (alpha-SMA) and collagen was measured by reverse transcriptase-polymerase chain reactions, immunocytochemical staining, and collagen assays.
   Results: The treatment with TGF-beta 1 increased the expression of alpha-SMA and collagen, and expression was markedly attenuated by the PPAR gamma agonists.
   Conclusions: PPAR gamma agonists inhibit the differentiation of TGF-beta 1-activated NPDFs and their production of collagen.
C1 [Lee, Heung-Man; Kang, Hee Jun; Park, Hyo Hun] Korea Univ, Coll Med, Dept Otorhinolaryngol Head & Neck Surg, Seoul 136705, South Korea.
   [Hong, Seok-Chan; Kim, Jin-Kook; Cho, Jae Hoon] Konkuk Univ, Coll Med, Dept Otorhinolaryngol Head & Neck Surg, Seoul 143729, South Korea.
RP Cho, JH (reprint author), Konkuk Univ, Coll Med, Konkuk Univ Hosp, Dept Otorhinolaryngol Head & Neck Surg, 4-12 Hwayang Dong, Seoul 143729, South Korea.
FU Korea Research Foundation; Korean Government [KRF-2007-1300144]
FX This work was supported by a Korea Research Foundation Grant funded by
   the Korean Government (KRF-2007-1300144).
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NR 27
TC 10
Z9 15
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD OCT
PY 2009
VL 118
IS 10
BP 721
EP 727
PG 7
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 509UZ
UT WOS:000271045500007
PM 19894400
ER

PT J
AU Pons, Y
   Lombard, B
AF Pons, Yoann
   Lombard, Bertrand
TI Anatomic Study of Middle Fossa Approach Landmarks Using an Image
   Guidance System
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE anatomy; computer-aided surgery; DigiPointeur; landmark; middle fossa
   approach; navigation
ID ARCUATE EMINENCE; SURGERY
AB Objectives: We sought to verify the relevance and reliability of the main temporal bone anatomic landmarks commonly used for the middle fossa approach and to test the use of digital technology to perform an accurate analysis of these landmarks.
   Methods: Ten fresh cadaveric temporal bones (5 heads) were analyzed by both computed tomographic imaging and dissection procedures, with the help of an image guidance system (DigiPointeur). Eight landmarks, which were selected for their wide citation in the otoneurosurgical literature, were studied.
   Results: Of the 8 landmarks studied, we obtained results similar to previously published data for 2 (the distance between the temporal squama and the internal auditory meatus [IAM] fundus, and the distance between the top of the anterior semicircular canal [ASCC] arch and the IAM fundus), but divergent measurements for the other 6 (the distance between the temporal squama and the arcuate eminence; the distance between the top of the ASCC arch and the cochlear promontory; the IAM roof thickness; the angle formed by the ASCC arch plane orientation and the IAM axis; the angle formed by the head of the malleus, the geniculate ganglion, and the IAM fundus; and the correspondence between the arcuate eminence and the top of the ASCC arch).
   Conclusions: The use of an image guidance system allowed us to make sharp and precise measurements of the main anatomic landmarks used during a middle fossa approach. We found 6 measurements to be different from those reported in previously published data out of the 8 landmarks studied.
C1 [Pons, Yoann] Val Grace Acad Mil Hosp, Dept Head & Neck Surg, Paris, France.
   [Lombard, Bertrand] Desgenettes Acad Mil Hosp, Dept Head & Neck Surg, Lyon, France.
RP Pons, Y (reprint author), Hop Val De Grace, Serv ORL & Chirurg Cervicofaciale, 74 Blvd Port Royal, F-75230 Paris 05, France.
CR BENFER RA, 1975, AM J PHYS ANTHROPOL, V42, P371, DOI 10.1002/ajpa.1330420305
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NR 13
TC 1
Z9 1
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD OCT
PY 2009
VL 118
IS 10
BP 728
EP 734
PG 7
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 509UZ
UT WOS:000271045500008
PM 19894401
ER

PT J
AU Ohno, T
   Hirano, S
   Rousseau, B
AF Ohno, Tsunehisa
   Hirano, Shigeru
   Rousseau, Bernard
TI Age-Associated Changes in the Expression and Deposition of Vocal Fold
   Collagen and Hyaluronan
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT 89th Annual Meeting of the American-Broncho-Esophagological-Association
CY MAY 28-29, 2009
CL Phoenix, AZ
SP Amer Broncho Esophagol Assoc
DE age; collagen; hyaluronan; turnover; vocal fold
ID MATRIX METALLOPROTEINASES; SENESCENT EXPRESSION; TISSUE INHIBITORS;
   FIBERS; MUCOSA; LUNGS; ACID; GENE; SKIN; MICE
AB Objectives: We investigated age-associated changes in the expression and deposition of collagen and hyaluronan (hyaluronic acid; HA) in aged vocal folds.
   Methods: Thirty Sprague-Dawley rats were involved in this study. For gene expression analyses, 15 animals were divided into 3 age groups of young (2 month), adult (9 month), and elderly (18 month) rats. Real-time polymerase chain reaction testing was used to quantify the messenger RNA expression of procollagen types I and III, matrix metalloproteinases 2 and 9, and HA synthases 1, 2, and 3. The remaining 15 animals were divided into 3 similar age groups and underwent histologic analyses designed to investigate age-associated changes in the deposition of collagen and HA.
   Results: The results revealed down-regulated expression of procollagen types I and III, matrix metalloproteinases 2 and 9, and HA synthases 1, 2, and 3 in adult and elderly vocal folds, compared to young vocal folds. Histologically, staining of collagen was dense in the vocal folds of adult and elderly rats, and HA was less dense in the vocal folds of adult and elderly rats than in young rats.
   Conclusions: A slowdown in the expression of procollagens and matrix metalloproteinases was associated with dense collagen in aged vocal folds, as observed in elderly humans. A similar decrease in the expression of genes that code for HA synthase was consistent with a low density of extracellular matrix HA in the vocal folds of elderly rats.
C1 [Ohno, Tsunehisa; Rousseau, Bernard] Vanderbilt Univ, Dept Otolaryngol, Bill Wilkerson Ctr Otolaryngol & Commun Sci, Nashville, TN 37232 USA.
   [Hirano, Shigeru] Kyoto Univ, Grad Sch Med, Dept Otolaryngol Head & Neck Surg, Kyoto, Japan.
RP Rousseau, B (reprint author), Vanderbilt Univ, Dept Otolaryngol, Bill Wilkerson Ctr Otolaryngol & Commun Sci, 1313 21st Ave S,Room 602, Nashville, TN 37232 USA.
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NR 17
TC 11
Z9 13
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD OCT
PY 2009
VL 118
IS 10
BP 735
EP 741
PG 7
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 509UZ
UT WOS:000271045500009
PM 19894402
ER

PT J
AU Luginbuhl, A
   Sanders, M
   Spiro, JD
AF Luginbuhl, Adam
   Sanders, Melinda
   Spiro, Jeffrey D.
TI Prevalence, Morphology, and Prognosis of Human Papillomavirus in
   Tonsillar Cancer
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE human papillomavirus; tonsillar cancer
ID SQUAMOUS-CELL CARCINOMA; NECK-CANCER; CYCLE CONTROL; GENE-PRODUCT; HEAD;
   SURVIVAL; EXPRESSION; P53; DNA; PATTERNS
AB Objectives: We sought to identify the prevalence of human papillomavirus (HPV) in tonsillar squamous cell carcinoma, and to examine the relationship of HPV to prognosis and tumor morphology.
   Methods: We performed in situ hybridization for HPV and retrospective clinical outcome analysis.
   Results: Of the 48 patients with tonsillar carcinoma, in situ hybridization identified 35% as HPV-positive tumors. Age-matched controls had no evidence of HPV. There was no significant difference between HPV-positive and HPV-negative patients regarding age (p = 0.34), tobacco consumption (p = 0.59), alcohol consumption (p = 0.91), or treatment method (p = 0.39). Forty-four patients were eligible for outcome analysis. The overall rate of recurrence in this population was 25%, and the disease-specific survival rate was 84%. There was no significant difference between the two groups either in the incidence of recurrence (p = 0.14) or in the disease-specific survival rate (p = 0.19). HPV-associated tumors developed from the tonsillar crypts significantly more frequently than did HPV-negative tumors (p = 0.01).
   Conclusions: As previously described, HPV is significantly associated with squamous cell carcinoma of the tonsil; however, HPV status in our series did not correlate with clinical outcome. Morphologically, we found that HPV-positive tumors had their origin in the tonsillar crypts, whereas HPV-negative tumors arose from the surface epithelium.
C1 [Luginbuhl, Adam] Thomas Jefferson Univ, Dept Otolaryngol, Philadelphia, PA 19103 USA.
   [Sanders, Melinda] Univ Connecticut, Dept Pathol, Farmington, CT USA.
   [Spiro, Jeffrey D.] Univ Connecticut, Dept Otolaryngol, Farmington, CT USA.
RP Luginbuhl, A (reprint author), 925 Chestnut St,6th Floor Otolaryngol, Philadelphia, PA 19107 USA.
FU University of Connecticut General Clinical Research Center [0640]
FX Supported by grant 0640 from the University of Connecticut General
   Clinical Research Center.
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NR 39
TC 10
Z9 10
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD OCT
PY 2009
VL 118
IS 10
BP 742
EP 749
PG 8
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 509UZ
UT WOS:000271045500010
PM 19894403
ER

PT J
AU Spanos, WC
   Brookes, JT
   Smith, MC
   Burkhart, HM
   Bell, EF
   Smith, RJH
AF Spanos, William C.
   Brookes, James T.
   Smith, Mark C.
   Burkhart, Harold M.
   Bell, Edward F.
   Smith, Richard J. H.
TI Unilateral Vocal Fold Paralysis in Premature Infants After Ligation of
   Patent Ductus Arteriosus: Vascular Clip Versus Suture Ligature
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE iatrogenic disease; ligation; patent ductus arteriosus; premature infant
ID LOW-BIRTH-WEIGHT; COMPLICATIONS; CLOSURE
AB Objectives: We investigated risk factors associated with unilateral iatrogenic vocal fold paralysis (IVFP) in the context of ligation of patent ductus arteriosus (PDA) and compared the rates of paralysis between vascular clip and suture ligation procedures.
   Methods: We performed a prospective examination of infants with isolated PDA treated surgically during 1995 to 2005. Statistical significance was determined with a 2-tailed t-test.
   Results: Of 68 PDA ligations, 13 cases of left-sided IVFP were diagnosed, for an overall incidence of 19%. All cases of IVFP occurred in 55 infants who weighed less than 1 kg at birth. Suture ligature was used in 60% of all PDA ligation patients, and vascular clips in 40%. The incidence of IVFP in patients with vascular clips (19%) was similar to the incidence in those with suture ligature (20%). Hoarseness or stridor was present in 69% of patients with IVFP, compared to 17% of normal controls (p < 0.001). The rate of aspiration was not increased in the IVFP group; however, 15% of the patients with IVFP had episodes of decreased oxygen saturation, versus 7% of infants with normal vocal fold mobility.
   Conclusions: A hoarse infant with a birth weight of less than 1 kg who has undergone PDA ligation should be examined for unilateral IVFP. Vascular clips and suture ligature are associated with similar rates of IVFP.
C1 [Spanos, William C.; Brookes, James T.; Smith, Mark C.; Smith, Richard J. H.] Univ Iowa, Dept Otolaryngol Head & Neck Surg, Iowa City, IA 52242 USA.
   [Burkhart, Harold M.] Univ Iowa, Dept Cardiothorac Surg, Iowa City, IA 52242 USA.
   [Bell, Edward F.] Univ Iowa, Dept Pediat, Iowa City, IA 52242 USA.
RP Spanos, WC (reprint author), Sanford Res USD, 1310 W 22nd St, Sioux Falls, SD 57108 USA.
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NR 10
TC 14
Z9 15
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD OCT
PY 2009
VL 118
IS 10
BP 750
EP 753
PG 4
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 509UZ
UT WOS:000271045500011
PM 19894404
ER

PT J
AU Zeitels, SM
   Lopez-Guerra, G
   Burns, JA
   Lutch, M
   Friedman, AM
   Hillman, RE
AF Zeitels, Steven M.
   Lopez-Guerra, Gerardo
   Burns, James A.
   Lutch, Matthew
   Friedman, Aaron M.
   Hillman, Robert E.
TI Microlaryngoscopic and Office-Based Injection of Bevacizumab (Avastin)
   to Enhance 532-nm Pulsed KTP Laser Treatment of Glottal Papillomatosis
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT 130th Annual Meeting of the American-Laryngological-Association Combined
   Otolaryngology Spring Meeting
CY MAY 28, 2009
CL Phoenix, AZ
SP Amer Laryngol Assoc
DE Avastin; bevacizumab; glottis; KTP laser; larynx; laser; papilloma;
   papillomatosis; recurrent respiratory papillomatosis; vocal cord; vocal
   fold; voice
ID RECURRENT RESPIRATORY PAPILLOMATOSIS; JUVENILE LARYNGEAL PAPILLOMATOSIS;
   ENDOTHELIAL GROWTH-FACTOR; VOCAL FOLD; DYE-LASER; CANCER; ANGIOGENESIS;
   MANAGEMENT; ANESTHESIA; DYSPLASIA
AB Objectives: Photoangiolytic lasers effectively treat glottal papillomatosis, but do not reliably prevent recurrence. Therefore, sublesional injections of the antiangiogenic agent bevacizumab (Avastin) were given to assess the effect on disease recurrence and phonatory function.
   Methods: A retrospective investigation was done in a pilot group of 10 adult patients with bilateral glottal papillomatosis who had prior angiolytic laser treatment with established patterns of recurrence. The patients underwent 5 bevacizumab injections (5 to 10 mg) into the diseased vocal folds along with 5327-nm pulsed KTP laser photoangiolysis treatments 4 to 6 weeks apart. Their disease resolution was compared to findings from prior laser treatment alone, and objective measures of vocal function (acoustic, aerodynamic, Voice-Related Quality of Life survey) were obtained.
   Results: All 10 patients had a greater than 90% reduction in recurrence. Four of the 10 had resolution. Four of the 10 have limited recurrent or persistent disease, receive injections of bevacizumab at 8- to 12-week intervals, and have not required laser treatment. Two of the 10 have ongoing periodic office-based KTP laser treatment along with bevacizumab injections. No patient has required microlaryngeal surgery with general anesthesia, and all 10 have had substantial improvement in vocal function.
   Conclusions: This pilot investigation provides preliminary evidence that bevacizumab injections enhance photoangiolytic laser treatment of glottal papillomatosis while enhancing phonatory function. Coupling an anti angiogenesis agent with pulsed KTP laser photoangiolysis is conceptually promising, since the mechanisms of action are complementary.
C1 [Zeitels, Steven M.] Massachusetts Gen Hosp, Ctr Laryngeal Surg & Voice Rehabil, Boston, MA 02114 USA.
   Harvard Univ, Sch Med, Dept Surg, Boston, MA 02115 USA.
RP Zeitels, SM (reprint author), Massachusetts Gen Hosp, Ctr Laryngeal Surg & Voice Rehabil, 1 Bowdoin Sq,11th Floor, Boston, MA 02114 USA.
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NR 68
TC 0
Z9 0
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD SEP
PY 2009
VL 118
IS 9
BP 2
EP 24
PG 23
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 499BB
UT WOS:000270190400001
ER

PT J
AU Kishirnoto, Y
   Hirano, S
   Kojima, T
   Kanemaru, S
   Ito, J
AF Kishirnoto, Yo
   Hirano, Shigeru
   Kojima, Tsuyoshi
   Kanemaru, Shin-ichi
   Ito, Juichi
TI Implantation of an Atelocollagen Sheet for the Treatment of Vocal Fold
   Scarring and Sulcus Vocalis
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT 89th Annual Meeting of the American-Broncho-Esophagological-Association
CY MAY 28-29, 2009
CL Phoenix, AZ
SP Amer Broncho Esophagol Assoc
DE atelocollagen sheet; human; sulcus vocalis; vocal fold scarring
ID ARTIFICIAL DERMIS IMPLANTATION; AUTOLOGOUS TRANSPLANTATION;
   PHONOSURGICAL TECHNIQUE; GLOTTAL INCOMPETENCE; FASCIA; DEFORMITY
AB Objectives: The management of vocal fold scarring and sulcus vocalis is challenging. These disorders are thought to be fibroplastic anomalies in the cover portion of the vocal fold that cause deterioration of the vibratory properties of the vocal fold mucosa. Histologic studies have revealed disorganization of extracellular matrix that needs to be addressed in the treatment of scarred vocal folds. Replacement of scar tissues with an appropriate implant may lead to regeneration of the vocal fold mucosa and its tissue properties. This retrospective case Study examined the feasibility of using all atelocollagen sheet as a regenerative implant.
   Methods: Six patients with a post-cordectomy scar or sulcus vocalis underwent implantation of an atelocollagen sheet into the lamina propria of the vocal folds. The procedure consisted of elevation of a microflap, dissection and removal of scar tissue, implantation of the material, and wound closure. Vocal function was evaluated before and after surgery by stroboscopic examination and by aerodynamic and acoustic analyses.
   Results: The postoperative changes of aerodynamic and acoustic parameters varied among patients; however, gradual improvement was seen in most cases over a year. Stroboscopic findings also revealed gradual improvement of vibratory properties in most cases.
   Conclusions: Implantation of an atelocollagen sheet may have restorative effects oil vocal fold scarring and sulcus vocalis in terms of tissue properties and function of the mucosa.
C1 [Hirano, Shigeru] Kyoto Univ, Dept Otolaryngol Head & Neck Surg, Grad Sch Med, Sakyo Ku, Kyoto 6068507, Japan.
RP Hirano, S (reprint author), Kyoto Univ, Dept Otolaryngol Head & Neck Surg, Grad Sch Med, Sakyo Ku, Kyoto 6068507, Japan.
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NR 14
TC 11
Z9 11
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD SEP
PY 2009
VL 118
IS 9
BP 613
EP 620
PG 8
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 499AX
UT WOS:000270190000001
PM 19810599
ER

PT J
AU Bolger, WE
AF Bolger, William E.
TI Piezoelectric Surgical Device in Endoscopic Sinus Surgery: An Initial
   Clinical Experience
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE chronic sinusitis; endoscopic sinus surgery; piezoelectric surgery;
   sinus endoscopy; ultrasonic bone aspirator
ID BONE SURGERY; AUGMENTATION PROCEDURE; CRANIOFACIAL SURGERY; MEMBRANE
   ELEVATION; OSTEOTOMY; PIEZOSURGERY
AB Revision endoscopic sinus surgery presents special challenges, such as the need to remove thick osteoneogenic bone close to the orbit or skull base. Currently available drills and microdebriders have shortcomings for this task, including risk to the underlying periorbita or dura. Recently, piezoelectric ultrasound technology has been used to remove bone while preserving adjacent soft tissue structures. This technology has been effective in several areas of the body, and it logically follows that it may have beneficial rhinologic applications. The purpose of this medical communication is to report an initial clinical experience with piezoelectric technology in revision sinus surgery. The piezoelectric Surgical device was used during revision endoscopic sinus surgery in 14 patients in the author's practice from June 2006 to January 2009. All patients had an underlying bone component to their sinus condition, such as osteoneogenesis adjacent to the orbit or skull base. The piezoelectric Surgical device performed successfully in removing osteoneogenic bone, and no complications were noted from its use. Piezoelectric surgical technology generates low-frequency ultrasound that dissects bone and appears to offer an option to mechanical drill instrumentation when used during endoscopic sinus surgery to address thick osteoneogenic bone. The clinical experience reported herein shows initial feasibility of the technology in selected cases of sinus surgery. On the basis of the favorable observations from this clinical experience, further exploration and discussion would appear to be valuable.
RP Bolger, WE (reprint author), 9218 Cedarcrest Dr, Bethesda, MD 20814 USA.
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NR 14
TC 8
Z9 8
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD SEP
PY 2009
VL 118
IS 9
BP 621
EP 624
PG 4
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 499AX
UT WOS:000270190000002
PM 19810600
ER

PT J
AU Canale, A
   Lacilla, M
   Perotti, M
   Pallavicino, F
   De Siena, L
   Albera, R
AF Canale, Andrea
   Lacilla, Michelangelo
   Perotti, Marco
   Pallavicino, Fabrizia
   De Siena, Luigi
   Albera, Roberto
TI Monitored Anesthesia Care With Target-Controlled Infusion in Vibroplasty
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE mixed hearing loss; monitored anesthesia care; vibroplasty
ID ROUND WINDOW; TRANSDUCER
AB Objectives: Correct positioning of a floating mass transducer during middle ear implant surgery is often problematic. With the use of monitored anesthesia care (MAC), however, deep sedation is maintained during surgery, followed by conscious sedation in which the patient can respond to test questions that investigate correct device position and function. The main aim of this study was to determine whether intraoperative audiometric assessment was feasible with MAC with target-controlled infusion in vibroplasty. An additional aim was to determine whether MAC was sufficiently comfortable for patients during the procedure.
   Methods: The study group comprised 8 patients who underwent vibroplasty under sedation. Before suturing, audiometric assessment was done by stimulating the external auditory processor with pure tones at 0.5. 1, 2, and 4 kHz. Blood pressure, arterial oxygen saturation level, heart rate, and end tidal carbon dioxide level were monitored during the procedure and at awakening.
   Results: Audiometric assessment was successfully completed in all 8 patients. The selected parameters indicated that no patient experienced pain or discomfort during surgery; the absence of discomfort was confirmed I to 2 hours after the operation by simple questioning.
   Conclusions: We found MAC to be an efficient and relatively safe technique for verifying the correct coupling of the floating mass transducer with the middle car during vibroplasty. The patients were able to respond appropriately to questions and commands; moreover, none reported having experienced pain or discomfort during the operation.
C1 [Canale, Andrea; Lacilla, Michelangelo; Pallavicino, Fabrizia; De Siena, Luigi; Albera, Roberto] Univ Turin, Dept Surg, Turin, Italy.
   [Perotti, Marco] Hosp Alessandria, Dept Otoneurosurg, ENT Div, Alessandria, Italy.
RP Canale, A (reprint author), Via G Servais 160, I-10146 Turin, Italy.
CR ALBERTINI A, 2001, MONITORED ANESTHESIA
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NR 23
TC 2
Z9 2
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD SEP
PY 2009
VL 118
IS 9
BP 625
EP 629
PG 5
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 499AX
UT WOS:000270190000003
PM 19810601
ER

PT J
AU Graham, SM
   Iseli, TA
   Karnell, LH
   Clinger, JD
   Hitchon, PW
   Greenlee, JDW
AF Graham, Scott M.
   Iseli, Tim A.
   Karnell, Lucy H.
   Clinger, John D.
   Hitchon, Patrick W.
   Greenlee, Jeremy D. W.
TI Endoscopic Approach for Pituitary Surgery Improves Rhinologic Outcomes
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT Annual Meeting of the Western Section of the Triological-Society
CY JAN 29-31, 2009
CL Henderson, NV
SP Triol Soc, Western Sect
DE complication; endoscopic surgery; pituitary gland; quality of life
ID ENDONASAL TRANSSPHENOIDAL APPROACH; TUMORS; COMPLICATIONS; TRANSNASAL;
   LESIONS
AB Objectives: We hypothesized that the endoscopic approach to pituitary surgery improves rhinology-specific quality of life and has satisfactory tumor outcomes compared with the open approach.
   Methods: Cases of pituitary surgery from the Department of Neurosurgery database included an inception cohort of all patients who had endoscopic procedures and consecutive patients who had open procedures between January 1998 and February 2008. The Sino-Nasal Outcome Test-22 was mailed.
   Results: Since January 1998, 71 endoscopic and 122 open pituitary surgeries had been performed. The mean follow-up was longer for open procedures (49.3 months) than for endoscopic procedures (18.8 months). Recurrence was more common after open surgery (28.4%) than after endoscopic surgery (18.2%; p = 0.219). The most common diagnosis was macroadenoma (77.1 % of endoscopic procedures and 93.4% of open procedures). The mean hospital stay was shorter for endoscopic procedures (4.1 days) than for open procedures (6.0 days; p < 0.001). Of patients who presented with visual deterioration, 53.8% with endoscopic surgery and 46.7% with open surgery had improvement. Among patients with normal preoperative hormonal function, 27.5% of patients in the endoscopy group and 29.4% of patients in the open group required medication for more than 2 months after surgery. Complications occurred in 33.3% of endoscopic procedures and 43.4% of open procedures. Cerebrospinal fluid leaks were more common in the endoscopy group (p = 0.035), and diabetes insipidus lasting more than 30 days was more common in the open group (p = 0.017). The mean Sino-Nasal Outcome Test-22 score was lower for patients in the endoscopy group (20.4) than for those in the open group (23.2; p = 0.41). Patients in the endoscopy group had a significantly lower rhinology-specific mean score (6.5) than did patients in the open group (9.2; p = 0.03).
   Conclusions: The endoscopic approach to pituitary surgery offers tumor outcomes comparable to those of open surgery, with no greater incidence of complications and an improved rhinology-specific quality of life.
C1 [Graham, Scott M.; Iseli, Tim A.; Karnell, Lucy H.; Clinger, John D.] Univ Iowa, Dept Otolaryngol Head & Neck Surg, Iowa City, IA 52242 USA.
   [Hitchon, Patrick W.; Greenlee, Jeremy D. W.] Univ Iowa, Dept Neurosurg, Iowa City, IA 52242 USA.
RP Graham, SM (reprint author), Univ Iowa Hosp & Clin, Dept Otolaryngol Head & Neck Surg, 200 Hawkins Dr, Iowa City, IA 52242 USA.
CR Browne JP, 2007, OTOLARYNG HEAD NECK, V136, P736, DOI 10.1016/j.otohns.2007.01.024
   de Divitiis E, 2007, NEUROSURGERY, V60, P46, DOI 10.1227/01.NEU.0000249211.89096.25
   Hopkins C, 2006, LARYNGOSCOPE, V116, P1494, DOI 10.1097/01.mlg.0000230399.24306.50
   Kabil MS, 2005, MINIM INVAS NEUROSUR, V48, P348, DOI 10.1055/s-2005-915635
   Koren I, 1999, LARYNGOSCOPE, V109, P1838, DOI 10.1097/00005537-199911000-00022
   Morley AD, 2006, CLIN OTOLARYNGOL, V31, P103, DOI 10.1111/j.1749-4486.2006.01155.x
   Senior BA, 2008, LARYNGOSCOPE, V118, P1842, DOI 10.1097/MLG.0b013e31817e2c43
   SETHI DS, 1995, J LARYNGOL OTOL, V109, P956
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NR 11
TC 22
Z9 23
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD SEP
PY 2009
VL 118
IS 9
BP 630
EP 635
PG 6
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 499AX
UT WOS:000270190000004
PM 19810602
ER

PT J
AU Thakar, A
   Lal, P
   Verma, R
AF Thakar, Alok
   Lal, Priti
   Verma, Rohit
TI Delayed Cerebrospinal Fluid Leak Following Septoplasty
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE cerebrospinal fluid leak; septoplasty
ID RHINORRHEA
AB We report on the clinical syndrome of delayed cerebrospinal fluid leak following septoplasty. We describe 2 such cases that we treated, and I other case described in the literature. A review of these 3 cases indicates a characteristic clinical and radiologic presentation and a consistent site of cerebrospinal fluid leak. All cases presented with cerebrospinal fluid leak 12 to 22 weeks after septoplasty and had slit-shaped dehiscences at the horizontal lamella of the cribriform plate. Endoscopic repair was successful in all. Delayed cerebrospinal fluid leaks may occur as a consequence of septal surgery. It is probable that uncontrolled twisting and rocking manipulations of the perpendicular plate of the ethmoid bone are transmitted to, and injure, the cribriform plate.
C1 [Thakar, Alok; Lal, Priti; Verma, Rohit] All India Inst Med Sci, Dept Otolaryngol Head & Neck Surg, New Delhi, India.
RP Lal, P (reprint author), Dr Ram Manohar Lohia Hosp, Dept Otolaryngol, New Delhi 110001, India.
CR BALLENGER JJ, 1985, DIS NOSE THROAT EAR, P88
   Eccles R, 2000, ACTA OTO-LARYNGOL, V120, P580, DOI 10.1080/000164800750000388
   HADDAD FS, 1985, AM J OTOLARYNG, V6, P443, DOI 10.1016/S0196-0709(85)80024-7
   MORLEY TP, 1957, SURG GYNECOL OBSTET, V104, P88
   Onerci TM, 2004, AM J OTOLARYNG, V25, P354, DOI 10.1016/j.amjoto.20040.03.005
   READING P, 1958, OPERATIVE SURG 18, V8, P74
   SESSIONS RB, 1986, CUMMINGS TXB OTOLARY, P673
NR 7
TC 4
Z9 4
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD SEP
PY 2009
VL 118
IS 9
BP 636
EP 638
PG 3
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 499AX
UT WOS:000270190000005
PM 19810603
ER

PT J
AU Asanau, A
   Timoshenko, AP
   Vercherin, P
   Martin, C
   Prades, JM
AF Asanau, Alexander
   Timoshenko, Andrei P.
   Vercherin, Paul
   Martin, Christian
   Prades, Jean-Michel
TI Sphenopalatine and Anterior Ethmoidal Artery Ligation for Severe
   Epistaxis
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT 115th Congress of the
   French-Society-of-Otorhinolaryngology-Face-and-Neck-Surgery
CY OCT 12, 2008
CL Paris, FRANCE
SP French Soc Otorhinolaryngol Face & Neck Surg
DE epistaxis; ethmoidal artery; intranasal ligation; sphenopalatine artery
ID POSTERIOR EPISTAXIS; INTRACTABLE EPISTAXIS; ENDOSCOPIC LIGATION;
   SURGICAL ANATOMY; EMBOLIZATION; MANAGEMENT; FORAMEN
AB Objectives: We describe the surgical treatment of severe epistaxis and evaluate the recurrence of bleeding in a non-randomized retrospective trial.
   Methods: We performed a retrospective study comparing bilateral endoscopic ligation of the sphenopalatine artery alone (ELSPA) and bilateral endoscopic ligation of the sphenopalatine artery with concomitant bilateral external ligation of the anterior ethmoidal artery (ELSPEA) in the management of persistent epistaxis. Clinical and hematologic information, preoperative and surgical care, and short- and long-term outcomes were analyzed. The main outcome measure was recurrence of epistaxis in the short- and long-term follow-tip periods.
   Results: Forty-five patients were enrolled in the study. There were 20 patients in group A (ELSPA) and 25 in group B (ELSPEA). Three patients in group A and no patients in group B had long-term (more than 2 weeks after surgery) rebleeding. The difference between the two groups was not statistically significant (p > 0.05).
   Conclusions: We conclude that ELSPA and ELSPEA are effective, well-tolerated, reliable procedures if performed by an experienced surgeon. Their failure can be explained by anatomic lateral nasal wall variations and perioperative technical difficulties. They can be appropriate methods to treat severe recurrent epistaxis refractory to repeated nasal packing.
C1 [Asanau, Alexander; Timoshenko, Andrei P.; Martin, Christian; Prades, Jean-Michel] Univ St Etienne, Ctr Hosp, Dept Otolaryngol Head & Neck Surg, North Hosp, F-42055 St Etienne 2, France.
   [Asanau, Alexander; Timoshenko, Andrei P.; Prades, Jean-Michel] Univ St Etienne, Ctr Hosp, Dept Anat, North Hosp, F-42055 St Etienne, France.
   [Vercherin, Paul] Univ St Etienne, Ctr Hosp, Dept Publ Hlth & Med Informat, North Hosp, F-42055 St Etienne 2, France.
RP Timoshenko, AP (reprint author), Univ St Etienne, Ctr Hosp, Dept Otolaryngol Head & Neck Surg, North Hosp, F-42055 St Etienne 2, France.
CR Abdelkader M, 2007, J LARYNGOL OTOL, V121, P759, DOI 10.1017/S0022215106003379
   Babin E, 2003, OTOLARYNG HEAD NECK, V128, P236, DOI 10.1067/mhn.2003.84
   Bolger WE, 1999, AM J RHINOL, V13, P81, DOI 10.2500/105065899782106814
   Budrovich R, 1992, Laryngoscope, V102, P1391
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   Shah Anand G, 2005, Ear Nose Throat J, V84, P296
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NR 30
TC 16
Z9 16
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD SEP
PY 2009
VL 118
IS 9
BP 639
EP 644
PG 6
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 499AX
UT WOS:000270190000006
PM 19810604
ER

PT J
AU Curry, JM
   Ezzat, WH
   Merton, DA
   Goldberg, BB
   Cognetti, DM
   Rosen, D
   Pribitkin, EA
AF Curry, Joseph M.
   Ezzat, Waleed H.
   Merton, Daniel A.
   Goldberg, Barry B.
   Cognetti, David M.
   Rosen, David
   Pribitkin, Edmund A.
TI Thyroid Lymphosonography: A Novel Method for Evaluating Lymphatic
   Drainage
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT 7th International Conference on Head and Neck Cancer
CY JUL 19-23, 2008
CL San Francisco, CA
SP Amer Head & Neck Soc
DE lymphosonography; sentinel node biopsy; thyroid
ID SENTINEL NODE BIOPSY; PROGNOSTIC-FACTORS; DIFFERENTIATED CARCINOMA; NECK
   DISSECTION; MELANOMA; HEAD; FEASIBILITY; METASTASIS; NEOPLASMS; MODEL
AB Objectives: We evaluated lymphosonography, or contrast-enhanced, ultrasonography (US)-guided sentinel lymph node (SLN) detection, as a technique for demonstrating the lymphatic drainage of the thyroid gland.
   Methods: In this prospective animal study, four 50-kg Yorkshire swine underwent transcutaneous injection of a US contrast agent and methylene blue dye into the thyroid gland. Contrast-enhanced US was used to identify draining lymphatic channels and SLNs. Sentinel node biopsy was conducted. Subsequently, bilateral neck and upper mediastinal dissection was carried out.
   Results: In 3 of 4 cases, a blue dye-positive and US contrast-positive SLN was identified, We identified SLNs in level IV in 2 cases. One case revealed 2 adjacent nodes in the superior mediastinum. In I case, a lymphatic channel was identified traveling into the mediastinum, but exposure of the SLN could not be obtained. No residual blue dye-positive or US contrast-positive nodes were identified on subsequent dissection.
   Conclusions: Lymphosonography of the thyroid gland in a porcine model correlates well with blue dye-guided sentinel node biopsy and is technically feasible, although in some cases access to the SLN may be difficult. This technique could potentially enable a detailed analysis of thyroidal lymphatic drainage if applied to humans.
C1 [Curry, Joseph M.; Ezzat, Waleed H.; Merton, Daniel A.; Goldberg, Barry B.; Cognetti, David M.; Rosen, David; Pribitkin, Edmund A.] Thomas Jefferson Univ, Dept Otolaryngol Head & Neck Surg, Philadelphia, PA 19107 USA.
RP Pribitkin, EA (reprint author), Thomas Jefferson Univ, Dept Otolaryngol Head & Neck Surg, 925 Chestnut St,6th Floor, Philadelphia, PA 19107 USA.
CR Caron NR, 2006, WORLD J SURG, V30, P833, DOI 10.1007/s00268-005-0358-5
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   Dixon E, 2000, WORLD J SURG, V24, P1396
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   McCulloch M, 2000, J AM SOC ECHOCARDIOG, V13, P959, DOI 10.1067/mje.2000.107004
   NEEDLEMAN L, 2001, J ULTRAS MED, V20, pS11
   Pelizzo MR, 2001, ACTA OTO-LARYNGOL, V121, P421
   Roh JL, 2008, ANN SURG ONCOL, V15, P1177, DOI 10.1245/s10434-008-9813-5
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NR 18
TC 2
Z9 2
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD SEP
PY 2009
VL 118
IS 9
BP 645
EP 650
PG 6
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 499AX
UT WOS:000270190000007
PM 19810605
ER

PT J
AU Bhattacharyya, N
   Kepnes, LJ
AF Bhattacharyya, Neil
   Kepnes, Lynn J.
TI Additional Disease Burden From Hay Fever and Sinusitis Accompanying
   Asthma
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE asthma; disease burden; hay fever; sinusitis
ID ALLERGIC RHINITIS; UNIFIED AIRWAY; UNITED-STATES; RHINOSINUSITIS; IMPACT
AB Objectives: We sought to determine the additional disease burden imparted by sinusitis and hay fever (allergic rhinitis) to patients with asthma.
   Methods: Patients with a diagnosis of asthma, hay fever, or sinusitis were extracted from the National Health Interview Survey for the 1997 to 2006 adult sample. Disease groups consisting of patients with asthma alone, asthma + hay fever, asthma + sinusitis, and asthma + hay fever + sinusitis were assembled. Disease groups were then compared according to total health-care visits per year, emergency room visits per year, health-care spending per year, and number of workdays lost per year to determine the disease burden.
   Results: We identified 11,813 patients (mean age, 45.5 years) who reported active asthma with or without hay fever or sinusitis comorbidity. Of these, 5,931 patients (50%) were identified with asthma alone, 1,134 (10%) with combined asthma + hay fever, 2,461 (21%) with asthma + sinusitis, and 2,287 (19%) with combined asthma + hay fever + sinusitis. Patients with asthma + sinusitis and those with asthma + sinusitis + hay fever had more total health-care visits and emergency room visits than did those with asthma alone (p < 0.001). All three groups with comorbidities had higher healthcare expenditures than did the group with asthma alone (p <= 0.002). Patients with asthma + sinusitis and those with asthma + hay fever + sinusitis missed more workdays than did patients in the group with asthma alone (10.0 and 13.1 versus 7.2, respectively; p < 0.001). Comorbid hay fever alone did not increase workdays lost (6.6 days; p = 0.983).
   Conclusions: The additional disease burden of sinusitis oil asthma is greater than that of hay fever. These data highlight the importance of identifying, comorbid diagnoses with asthma.
C1 [Bhattacharyya, Neil; Kepnes, Lynn J.] Brigham & Womens Hosp, Div Otolaryngol, Boston, MA 02115 USA.
   [Bhattacharyya, Neil] Harvard Univ, Sch Med, Dept Otol & Laryngol, Boston, MA USA.
RP Bhattacharyya, N (reprint author), Brigham & Womens Hosp, Div Otolaryngol, 45 Francis St, Boston, MA 02115 USA.
CR Anand VK, 2004, ANN OTO RHINOL LARYN, V113, P3
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   Valovirta Erkka, 2006, BMC Pulm Med, V6 Suppl 1, pS3, DOI 10.1186/1471-2466-6-S1-S3
NR 23
TC 5
Z9 5
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD SEP
PY 2009
VL 118
IS 9
BP 651
EP 655
PG 5
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 499AX
UT WOS:000270190000008
PM 19810606
ER

PT J
AU Xu, W
   Han, DM
   Hou, LZ
   Hu, R
   Wang, L
AF Xu, Wen
   Han, Demin
   Hou, Lizhen
   Hu, Rong
   Wang, Lei
TI Clinical and Electrophysiological Characteristics of Larynx in
   Myasthenia Gravis
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE electromyography; laryngeal muscle; myasthenia gravis; voice disorder
AB Objectives: We investigated the clinical and electrophysiological characteristics of the larynx in patients with myasthenia gravis (MG).
   Methods: Thirty-two cases of MG were analyzed. The laryngeal behaviors and characteristics of laryngeal electromyography were evaluated, and voice assessment and repetitive nerve stimulation (RNS) tests were conducted.
   Results: The initial symptoms of patients were ptosis and/or diplopia in 28, dysphagia and slurred speech in 3, and limb weakness in 1. Only 8 patients had slight hoarseness and vocal fatigue, and 4 patients had positive laryngeal signs. When compared with normal subjects, the patients with MG had worse results on the acoustic analysis of shimmer, their normalized noise energy was greater, and the harmonics-to-noise ratio and maximum phonation time were significantly lower. The RNS findings were positive in 28 patients and negative in 4 patients. The average (+/-SD) amplitude decrement was 31.9% +/- 19.1%. The mean number of involved laryngeal Muscles was 2.22 +/- 1.35. Cricothyroid muscles were involved in 26 cases, thyroarytenoid muscles were involved in 14 cases, posterior cricoarytenoid muscles were involved in 6 cases, and lateral cricoarytenoid muscles were involved in 2 cases.
   Conclusions: Although few patients presented with laryngeal symptoms as their initial symptoms, most patients with MG exhibited asymmetry and abnormal findings on laryngeal electromyography. The RNS test for laryngeal muscles is a more sensitive indicator for the diagnosis of MG, especially in the cricothyroid muscle.
C1 [Xu, Wen; Han, Demin; Hou, Lizhen; Hu, Rong; Wang, Lei] Capital Med Univ, Dept Otorhinolaryngol Head & Neck Surg, Beijing Tongren Hosp, Beijing 100730, Peoples R China.
RP Han, DM (reprint author), Capital Med Univ, Dept Otorhinolaryngol Head & Neck Surg, Beijing Tongren Hosp, 1 Dongjiao Minxiang, Beijing 100730, Peoples R China.
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NR 9
TC 6
Z9 9
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD SEP
PY 2009
VL 118
IS 9
BP 656
EP 661
PG 6
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 499AX
UT WOS:000270190000009
PM 19810607
ER

PT J
AU Rodel, RMW
   Matthias, C
   Blomeyer, BD
   Wolff, HA
   Jung, K
   Christiansen, H
AF Roedel, Ralph M. W.
   Matthias, Christoph
   Blomeyer, Barbara D.
   Wolff, Hendrik A.
   Jung, Klaus
   Christiansen, Hans
TI Impact of Distant Metastasis in Patients With Cervical Lymph Node
   Metastases From Cancer of an Unknown Primary Site
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE cancer of unknown primary; distant metastasis; neck lymph node
   metastasis; treatment result
ID SQUAMOUS-CELL CARCINOMA; PRIMARY TUMOR; NECK; RADIOTHERAPY; HEAD;
   RADIATION; PATTERNS; OUTCOMES; SURGERY; THERAPY
AB Objectives: Treatment methods for patients with cervical cancer of an unknown primary site (CUP) are still under discussion. The purpose of this retrospective study was to analyze the oncological follow-up of 58 patients treated for cervical CUP.
   Methods: From 1986 to 2006, 58 patients with cervical CUP were treated at the authors' institution. Treatment consisted of neck dissection alone in 8, irradiation or chemoradiation in 5, combined surgery and radiotherapy in 28, and surgery and radiochemotherapy in 17.
   Results: The 3-year and 5-year overall survival rates for all patients were 52.9% and 40.9%, respectively. The 3-year and 5-year disease-specific Survival rates were 50.9% and 39.7%, respectively. The 3-year and 5-year neck control rates were 73.7% and 67.3%, respectively. Neck dissection followed by radiochemotherapy was associated with the best 3-year and 5-year locoregional control rates. Extracapsular extension was a predictor of survival, but not of neck control. Distant metastases developed in about one third of all patients and were the most frequent cause of tumor-related death in cases of advanced neck disease.
   Conclusions: Despite the fact that regional control can be achieved in many cases, survival rates may be limited by distant metastasis, especially in patients with advanced neck disease.
C1 [Roedel, Ralph M. W.; Matthias, Christoph; Blomeyer, Barbara D.] Univ Gottingen, Dept Otorhinolaryngol Head & Neck Surg, Gottingen, Germany.
   [Wolff, Hendrik A.; Christiansen, Hans] Univ Gottingen, Dept Radiotherapy & Radiooncol, Gottingen, Germany.
   [Jung, Klaus] Univ Gottingen, Dept Med Stat, Gottingen, Germany.
RP Rodel, RMW (reprint author), Univ HNO Klin, Robert Koch Str 40, D-37075 Gottingen, Germany.
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NR 20
TC 8
Z9 8
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD SEP
PY 2009
VL 118
IS 9
BP 662
EP 669
PG 8
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 499AX
UT WOS:000270190000010
PM 19810608
ER

PT J
AU Bahmad, F
   DePalma, SR
   Merchant, SN
   Bezerra, RL
   Oliveira, CA
   Seidman, CE
   Seidman, JG
AF Bahmad, Fayez, Jr.
   DePalma, Steven R.
   Merchant, Saumil N.
   Bezerra, Roberta L.
   Oliveira, Carlos A.
   Seidman, Christine E.
   Seidman, Jonathan G.
TI Locus for Familial Migrainous Vertigo Disease Maps to Chromosome 5q35
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE familial disease; gene; linkage study; migraine; vertigo
ID SUSCEPTIBILITY LOCUS; MENIERES-SYNDROME; LINKAGE; AURA; GENOME; GENES
AB Objectives: Migrainous vertigo (episodic vertigo associated with migraine) is sometimes inherited as an autosomal dominant trait. However, neither disease genes nor loci that might be responsible have been reported. We sought to map the genetic locus for familial migrainous vertigo in a 4-generation family and to define the progression of disease in this family.
   Methods: We studied 23 members in a family in whom migrainous vertigo was inherited as an autosomal dominant trait. Clinical information obtained included case histories and results of otolaryngological, neurologic, audiometric, and imaging evaluations. Genome-wide linkage analysis was performed with Affymetrix Genechip Human Mapping 10K microarrays. Genotyping of family members' DNA with microsatellite markers was used to further assess candidate loci identified from the whole-genome scan.
   Results: Of 23 family members, 10 suffered from migrainous vertigo beginning after 35 years of age. Migraine head aches usually preceded the onset of vertigo by 15 to 20 years. Longitudinal audiometric Studies over 12 years showed stable, high-frequency sensorineural hearing loss consistent with presbycusis. Low-frequency or fluctuating hearing loss was not observed. The results of vestibular testing and imaging Studies were unremarkable. Genetic analysis defined a 12.0 MB interval on chromosome 5q35 between loci rs244895 and D5S2073 that contained the disease gene (logarithm of odds score, 4.21).
   Conclusions: We report the first locus for familial migrainous vertigo, which mapped to 5q35.
C1 [Bahmad, Fayez, Jr.; Merchant, Saumil N.] Harvard Univ, Dept Otol & Laryngol, Sch Med, Massachusetts Eye & Ear Infirm, Boston, MA 02114 USA.
   [Bahmad, Fayez, Jr.; DePalma, Steven R.; Seidman, Christine E.; Seidman, Jonathan G.] Harvard Univ, Dept Genet, Sch Med, Massachusetts Eye & Ear Infirm, Boston, MA 02114 USA.
   [Seidman, Christine E.] Howard Hughes Med Inst, Boston, MA 02115 USA.
   [Bahmad, Fayez, Jr.; Bezerra, Roberta L.; Oliveira, Carlos A.] Univ Brasilia, Dept Otolaryngol Head & Neck Surg, Sch Med, Brasilia Univ Hosp, Brasilia, DF, Brazil.
RP Merchant, SN (reprint author), Harvard Univ, Dept Otol & Laryngol, Sch Med, Massachusetts Eye & Ear Infirm, 243 Charles St, Boston, MA 02114 USA.
FU National Institutes of Health [U24DC008559]; National Council for
   Scientific and Technological Development-CNPq, Brazil (Bahmad); Lakshmi
   Mittal and Axel Eliasen
FX Supported by grants from the National Institutes of Health (J. G.
   Seidman and C. E. Seidman, and U24DC008559 to Merchant), by the National
   Council for Scientific and Technological Development-CNPq, Brazil
   (Bahmad), and by Lakshmi Mittal and Axel Eliasen.
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NR 31
TC 13
Z9 14
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD SEP
PY 2009
VL 118
IS 9
BP 670
EP 676
PG 7
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 499AX
UT WOS:000270190000011
PM 19810609
ER

PT J
AU Johnston, N
   Wells, CW
   Samuels, TL
   Blumin, JH
AF Johnston, Nikki
   Wells, Clive W.
   Samuels, Tina L.
   Blumin, Joel H.
TI Pepsin in Nonacidic Refluxate Can Damage Hypopharyngeal Epithelial Cells
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT 89th Annual Meeting of the American-Broncho-Esophagological-Association
CY MAY 28-29, 2009
CL Phoenix, AZ
SP Amer Broncho Esophagol Assoc
DE cytotoxicity; larynx; nonacid reflux; pepsin; reflux
ID CARBONIC-ANHYDRASE-III; GASTROESOPHAGEAL-REFLUX; LARYNGOPHARYNGEAL
   REFLUX; ESOPHAGEAL MUCOSA; DISEASE; PH; IMPEDANCE; SYMPTOMS; ACIDITY;
   STRESS
AB Objectives: Studies using combined multichannel intraluminal impedance with pH monitoring reveal a role for nonacidic reflux in laryngopharyngeal symptoms and injury. We have discovered that pepsin is taken up by laryngeal epithelial cells by receptor-mediated endocytosis. This finding reveals a novel mechanism by which pepsin could cause cell damage, potentially even in nonacidic refluxate. The objective of this study was to determine whether pepsin, at pH 7.4 and thus in nonacidic refluxate, causes cell damage.
   Methods: Cultured hypopharyngeal epithelial (FaDu) cells were exposed to human pepsin (0.1 mg/mL) at pH 7.4 for either 1 hour or 12 hours at 37 degrees C and analyzed by electron microscopy, cytotoxicity assay, and SuperArray.
   Results: We report mitochondrial and Golgi complex damage in cells exposed to pepsin at neutral pH, observed by electron microscopy. We also report cell toxicity of pepsin at pH 7.4, measured by a cytotoxicity assay. Furthermore, using SuperArray, we found that pepsin at pH 7.4 significantly alters the expression levels of multiple genes implicated in stress and toxicity.
   Conclusions: These findings are perhaps the first to explain why many patients have symptoms and injury associated with nonacidic reflux, and could have important implications for the development of new therapies for reflux, such as pepsin receptor antagonists and/or irreversible inhibitors of peptic activity.
C1 [Johnston, Nikki; Samuels, Tina L.; Blumin, Joel H.] Med Coll Wisconsin, Dept Otolaryngol & Commun Sci, Milwaukee, WI 53226 USA.
   [Wells, Clive W.] Med Coll Wisconsin, Dept Microbiol & Mol Genet, Milwaukee, WI 53226 USA.
RP Johnston, N (reprint author), Med Coll Wisconsin, Dept Otolaryngol & Commun Sci, 9200 W Wisconsin Ave, Milwaukee, WI 53226 USA.
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NR 29
TC 29
Z9 30
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD SEP
PY 2009
VL 118
IS 9
BP 677
EP 685
PG 9
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 499AX
UT WOS:000270190000012
PM 19810610
ER

PT J
AU Gillespie, MB
   Dozier, TS
   Day, TA
   Martin-Harris, B
   Nguyen, SA
AF Gillespie, M. Boyd
   Dozier, Thomas S.
   Day, Terry A.
   Martin-Harris, Bonnie
   Nguyen, Shaun A.
TI Effectiveness of Calcium Hydroxylapatite Paste in Vocal Rehabilitation
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT 112th Annual Meeting of the
   American-Academy-of-Otolaryngology-Head-and-Neck-Surgery
CY SEP 21-24, 2008
CL Chicago, IL
SP Amer Acad Otolaryngol Head & Neck Surg
DE calcium hydroxylapatite; hydroxylapatite; vocal cord medialization;
   vocal cord reconstruction; vocal fold medialization; vocal fold
   reconstruction
ID FOLD AUGMENTATION; GLOTTIC CARCINOMA; FAT AUGMENTATION; LASER-SURGERY;
   VOICE; CORDECTOMY; INSUFFICIENCY; IMPROVEMENT; INJECTION
AB Objectives: We determined the effectiveness of calcium hydroxylapatite (CaHA) paste in vocal rehabilitation.
   Methods: We examined a retrospective case series of 39 adult patients who underwent CaHA paste injection for vocal fold rehabilitation over a 5-year period. The outcomes included the change in the Voice Handicap Index (VHI) score; procedure-related complications; and the need for follow-up voice procedures.
   Results: The VHI scores demonstrated overall improvement, with a decrease from the preoperative mean of 61.2 +/- 24.0 to a postoperative mean of 35.9 +/- 26.3 (p = 0.0001) after a mean follow-up time of 17.8 +/- 13.6 months. The procedure was more likely to succeed in patients with paralysis and/or paresis than in patients with glottic soft tissue defects. After injection, the VHI scores worsened in 3 of 7 patients (43%) in the soft tissue defect group, compared to only 2 of 28 (7%) in the paralysis and/or paresis group (p = 0.04). Four of 7 patients with soft tissue defects (57%) required secondary vocal procedures to improve the voice, compared to only 2 of 32 (6%) in the paralysis and/or paresis group (p = 0.006).
   Conclusions: Injection of CaHA paste results in significantly improved vocal scores in the majority of patients. Use of the paste was less satisfactory in patients with soft tissue defects because of poor retention of the paste in the scarred vocal fold remnant.
C1 [Gillespie, M. Boyd; Dozier, Thomas S.; Day, Terry A.; Martin-Harris, Bonnie; Nguyen, Shaun A.] Med Univ S Carolina, Dept Otolaryngol Head & Neck Surg, Charleston, SC 29425 USA.
RP Gillespie, MB (reprint author), Med Univ S Carolina, Dept Otolaryngol Head & Neck Surg, 135 Rutledge Ave MSC 550, Charleston, SC 29425 USA.
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   Tanna N, 2006, ARCH OTOLARYNGOL, V132, P1379, DOI 10.1001/archotol.132.12.1379
   Zeitels Steven M, 2002, Ann Otol Rhinol Laryngol Suppl, V190, P3
NR 22
TC 6
Z9 6
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD AUG
PY 2009
VL 118
IS 8
BP 546
EP 551
PG 6
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 484RP
UT WOS:000269065300002
PM 19746750
ER

PT J
AU Caballero, M
   Navarrete, P
   Prades, E
   Domenech, J
   Bernal-Sprekelsen, M
AF Caballero, Miguel
   Navarrete, Pilar
   Prades, Eduard
   Domenech, Juan
   Bernal-Sprekelsen, Manuel
TI Randomized, Placebo-Controlled Evaluation of Chlorobutanol, Potassium
   Carbonate, and Irrigation in Cerumen Removal
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE cerumen; chlorobutanol; hypoacusis; potassium carbonate
ID CLINICAL-TRIAL; EAR WAX; DOCUSATE
AB Objectives: We evaluated the efficacy over a short period of time of two ceruminolytic products, Otocerum (chlorobutanol, phenol, turpentine essence, ethyl alcohol; Reig Jofre Laboratories, Barcelona, Spain) and Taponoto (potassium carbonate, ethyl alcohol, glycerol, thymol; Teofarma Iberica SA, Barcelona), in adult subjects with complete occlusion of the ear canal due to cerumen.
   Methods: Ninety subjects with complete occlusion of the ear canal were enrolled in a randomized, subject- and observer-blinded, placebo-controlled clinical trial. The subjects were randomly assigned to one of three different treatments: Otocerum, Taponoto, or sterile saline solution (control group). The test medication was instilled into an occluded ear for 1,5 minutes. After this treatment, the subject's ear was irrigated with 50 mL of water. The main outcome was the proportion of tympanic membranes completely visualized after treatment.
   Results: One subject among the 90 enrolled did not accept a second ear irrigation and was excluded from the study. Neither Otocerum nor Taponoto was superior to saline solution. Cerumen occlusion resolved in 21 of 32 subjects treated with Otocerum (65.6%), 16 of 29 treated with Taponoto (55.2%), and 12 of 28 treated with saline solution (42.9%).
   Conclusions: The use of Taponoto or Otocerum did not significantly improve the proportion of tympanic membranes that were completely visualized compared with saline solution when they were instilled 15 minutes before ear irrigation.
C1 [Caballero, Miguel; Prades, Eduard; Domenech, Juan; Bernal-Sprekelsen, Manuel] Hosp Clin Barcelona, Dept Otorhinolaryngol, IDIBAPS, E-08036 Barcelona, Spain.
   [Navarrete, Pilar] Univ Barcelona, Primary Hlth Care Ctr, CAPSE, Barcelona, Spain.
RP Caballero, M (reprint author), Hosp Clin Barcelona, Dept Otorhinolaryngol, IDIBAPS, Villarroel 170,Esc 8,2A, E-08036 Barcelona, Spain.
RI CABALLERO, MIGUEL/I-7216-2012
CR BURTON MJ, 2003, COCHRANE DB SYST REV, P4400
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   MEEHAN P, 2002, ACAD EMERG MED, V9, P521, DOI 10.1197/aemj.9.5.521-b
   Roland PS, 2004, ARCH OTOLARYNGOL, V130, P1175, DOI 10.1001/archotol.130.10.1175
   Singer AJ, 2000, ANN EMERG MED, V36, P228, DOI 10.1067/mem.2000.109166
   Whatley VN, 2003, ARCH PEDIAT ADOL MED, V157, P1177, DOI 10.1001/archpedi.157.12.1177
NR 10
TC 0
Z9 1
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD AUG
PY 2009
VL 118
IS 8
BP 552
EP 555
PG 4
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 484RP
UT WOS:000269065300003
PM 19746751
ER

PT J
AU Talmon, Y
   Ishai, R
   Samet, A
   Sturman, A
   Roguin, N
AF Talmon, Yoav
   Ishai, Reuven
   Samet, Alvin
   Sturman, Alexander
   Roguin, Nathan
TI Acute Myopericarditis Complicating Acute Tonsillitis: A Prospective
   Study
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE myopericarditis; pericarditis; tonsillitis
ID ACUTE NONRHEUMATIC MYOPERICARDITIS; STREPTOCOCCAL TONSILLITIS
AB Objectives: We describe a prospective study of 100 consecutive cases of acute tonsillitis tested for cardiac involvement. There was 1 clear-cut case of acute myopericarditis and 5 more patients with pathological findings suggesting cardiac complication.
   Methods: During a 6-month period (November 2006 to April 2007), we prospectively studied 100 consecutive patients admitted to our department with acute tonsillitis for the purpose of detecting acute myopericarditis. We obtained for each patient a serial electrocardiogram and echocardiogram, and took blood samples. All blood samples were analyzed for the presence of the marker troponin 1 and for cardiac enzymes.
   Results: One patient (male) had a definitive diagnosis of myopericarditis, and another 5 patients (3 of whom were female) had abnormal cardiac findings suggestive of myopericarditis.
   Conclusions: Otolaryngologists should be aware of the possibility of cardiac involvement in acute tonsillitis and perform an adequate workup whenever such a possibility is suspected.
C1 [Talmon, Yoav; Ishai, Reuven; Samet, Alvin] Western Galilee Hosp, Dept Otolaryngol Head & Neck Surg, IL-22100 Nahariyya, Israel.
   [Sturman, Alexander; Roguin, Nathan] Western Galilee Hosp, Dept Cardiol, IL-22100 Nahariyya, Israel.
   [Talmon, Yoav; Roguin, Nathan] Technion Israel Inst Technol, Bruce Rappaport Fac Med, IL-31096 Haifa, Israel.
RP Talmon, Y (reprint author), Western Galilee Hosp, Dept Otolaryngol Head & Neck Surg, POB 21, IL-22100 Nahariyya, Israel.
CR Ammann P, 2004, BRIT MED J, V328, P1028, DOI 10.1136/bmj.328.7447.1028
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   KHAVANDI A, 2008, AM J EMERG MED, V26
   PUTTERMAN C, 1991, CARDIOLOGY, V78, P156, DOI 10.1159/000174780
   Said SAM, 1998, NETH J MED, V53, P266, DOI 10.1016/S0300-2977(98)00100-4
   Talmon Y, 2008, ANN OTO RHINOL LARYN, V117, P295
NR 9
TC 3
Z9 3
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD AUG
PY 2009
VL 118
IS 8
BP 556
EP 558
PG 3
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 484RP
UT WOS:000269065300004
PM 19746752
ER

PT J
AU Ohno, T
   Yoo, MJ
   Swanson, ER
   Hirano, S
   Ossoff, RH
   Rousseau, B
AF Ohno, Tsunehisa
   Yoo, Mi Jin
   Swanson, Erik R.
   Hirano, Shigeru
   Ossoff, Robert H.
   Rousseau, Bernard
TI Regenerative Effects of Basic Fibroblast Growth Factor on Extracellular
   Matrix Production in Aged Rat Vocal Folds
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT 89th Annual Meeting of the American-Broncho-Esophagological-Association
CY MAY 28-29, 2009
CL Phoenix, AZ
SP Amer Broncho Esophagol Assoc
DE aged vocal fold; basic fibroblast growth factor; hyaluronan synthase;
   matrix metalloproteinase; procollagen type I; regenerative effect
ID METALLOPROTEINASES; EXPRESSION; VOICE; GENE
AB Objectives: We investigated acute changes in extracellular matrix (ECM) gene expression and histologic changes in the deposition of collagen and hyaluronan (hyaluronic acid; HA) after basic fibroblast growth factor (bFGF) treatment of the aged rat vocal fold.
   Methods: For the polymerase chain reaction (PCR) experiments, we divided ten 18-month-old Sprague-Dawley rats into two groups that received serial injections of sham (saline solution) or bFGF (2 ng/mu L) and euthanized them 2 weeks after the initial injection to investigate acute changes in ECM gene expression. We treated a separate group of 5 animals unilaterally and sacrificed them 4 weeks after the initial injection to investigate histologic changes in the deposition of collagen and HA.
   Results: Real-time PCR revealed significantly up-regulated HA synthase (HAS)-2, HAS-3, matrix metalloproteinase (MMP)-2, and procollagen type I gene expression in the bFGF treatment group as compared to the sham treatment group. Histologic staining revealed significantly increased deposition of HA in the bFGF-treated vocal fold as compared to the sham-treated vocal fold. No differences in ECM collagen levels were observed between treatment sides.
   Conclusions: Basic fibroblast growth factor induced the up-regulation of HAS-2, HAS-3, MMP-2, and procollagen type 1. Histologically, aged vocal folds treated with bFGF revealed increased deposition of HA as compared to sham-treated vocal folds.
C1 [Ohno, Tsunehisa; Yoo, Mi Jin; Swanson, Erik R.; Ossoff, Robert H.; Rousseau, Bernard] Vanderbilt Univ, Dept Otolaryngol, Bill Wilkerson Ctr Otolaryngol & Commun Sci, Nashville, TN 37232 USA.
   [Hirano, Shigeru] Kyoto Univ, Grad Sch Med, Dept Otolaryngol Head & Neck Surg, Kyoto, Japan.
RP Rousseau, B (reprint author), Vanderbilt Univ, Dept Otolaryngol, Bill Wilkerson Ctr Otolaryngol & Commun Sci, 1313 21st Ave S,Room 602, Nashville, TN 37232 USA.
CR Butler JE, 2001, LARYNGOSCOPE, V111, P907, DOI 10.1097/00005537-200105000-00029
   Ding H, 2001, J GERONTOL A-BIOL, V56, pB145
   Ford C, 2004, ARCH OTOLARYNGOL, V130, P1117, DOI 10.1001/archotol.130.9.1117
   Hammond TH, 2000, ANN OTO RHINOL LARYN, V109, P913
   Hirano S, 2004, LARYNGOSCOPE, V114, P2161, DOI 10.1097/01.mlg.0000149450.37640.db
   Hirano S, 2008, LARYNGOSCOPE, V118, P2254, DOI 10.1097/MLG.0b013e3181845720
   Hirano S, 2005, ANN OTO RHINOL LARYN, V114, P304
   Manuel JA, 2006, MATRIX BIOL, V25, P505, DOI 10.1016/j.matbio.2006.07.008
   Ohno T, 2008, ANN OTO RHINOL LARYN, V117, P696
   Price SJ, 2001, J BIOL CHEM, V276, P7549, DOI 10.1074/jbc.M010242200
   Sato K, 2002, ANN OTO RHINOL LARYN, V111, P15
   Sternlicht MD, 2001, ANNU REV CELL DEV BI, V17, P463, DOI 10.1146/annurev.cellbio.17.1.463
   Tateya T, 2005, ANN OTO RHINOL LARYN, V114, P183
NR 13
TC 12
Z9 12
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD AUG
PY 2009
VL 118
IS 8
BP 559
EP 564
PG 6
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 484RP
UT WOS:000269065300005
PM 19746753
ER

PT J
AU Tamir, S
   Schwartz, Y
   Peleg, U
   Perez, R
   Sichel, JY
AF Tamir, Sharon
   Schwartz, Yehuda
   Peleg, Uri
   Perez, Ronen
   Sichel, Jean-Yves
TI Acute Mastoiditis in Children: Is Computed Tomography Always Necessary?
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT 8th International Conference of the
   European-Society-of-Paediatric-Otorhinolaryngology
CY JUN 07-10, 2008
CL Budapest, HUNGARY
SP European Paediat Otorhinolaryngol
DE mastoiditis; middle ear infection; myringotomy
ID OTITIS-MEDIA; INTRACRANIAL COMPLICATIONS; RADIATION
AB Objectives: Acute mastoiditis (AM) is the most common intratemporal complication of acute otitis media in children. In the past decade, reports have indicated a rise in the incidence of AM in the pediatric Population. A parallel rise in the use of computed tomography (CT) imaging has Occurred. The rise in the use of CT scanning in the pediatric population, entraining with it a rise in pediatric brain irradiation, has led us to question the necessity of using CT for pediatric patients with AM.
   Methods: We reviewed the medical files of pediatric patients who had AM in the years 2005 through 2007.
   Results: Fifty patients were identified. The gender distribution was equal, and the ages ranged from 4 months to 12 years. Of the 46 patients who were admitted to Our institution "de novo," only 2 underwent CT scanning on admission, and 4 other patients had CT performed during hospitalization. The majority of patients (92%) with AM did not have a CT scan performed and were treated conservatively with no complications.
   Conclusions: In most pediatric patients, CT does not seem to be indispensable in the diagnosis of AM. Conservative therapy and close follow-up seem to suffice for most.
C1 [Tamir, Sharon; Schwartz, Yehuda; Peleg, Uri; Perez, Ronen; Sichel, Jean-Yves] Shaare Zedek Med Ctr, Dept Otolaryngol Head & Neck Surg, IL-91031 Jerusalem, Israel.
RP Tamir, S (reprint author), Shaare Zedek Med Ctr, Dept Otolaryngol Head & Neck Surg, POB 3235, IL-91031 Jerusalem, Israel.
CR Bluestone CD, 1983, PEDIAT OTOLARYNGOLOG, P549
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   Go C, 2000, INT J PEDIATR OTORHI, V52, P143, DOI 10.1016/S0165-5876(00)00283-4
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   Kvestad E, 2000, INT J PEDIATR OTORHI, V52, P149, DOI 10.1016/S0165-5876(00)00287-1
   Linder TE, 2000, INT J PEDIATR OTORHI, V56, P129, DOI 10.1016/S0165-5876(00)00410-9
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   Stahelin-Massik J, 2008, EUR J PEDIATR, V167, P541, DOI 10.1007/s00431-007-0549-1
NR 21
TC 10
Z9 10
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD AUG
PY 2009
VL 118
IS 8
BP 565
EP 569
PG 5
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 484RP
UT WOS:000269065300006
PM 19746754
ER

PT J
AU Yetiser, S
   Hidir, Y
AF Yetiser, Sertac
   Hidir, Yusuf
TI Temporalis Fascia and Cartilage-Perichondrium Composite Shield Grafts
   for Reconstruction of the Tympanic Membrane
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE cartilage; perichondrium; temporalis fascia; tympanoplasty
ID TENSA RETRACTION CHOLESTEATOMA; MIDDLE-EAR; TYMPANOPLASTY;
   MYRINGOPLASTY; PERFORATION
AB Objectives: We sought to compare the long-term functional results of tympanic membrane reconstruction with temporalis fascia and cartilage shield grafting.
   Methods: This study includes 113 patients who had tympanoplasty type I tympanic membrane reconstruction between 1997 and 2007, 47 with tragal cartilage and 66 with temporalis fascia. Fourteen patients in the cartilage group and 9 patients in the temporalis fascia group also had mastoidectomy. The average follow-up was 3.2 years. The hearing threshold was calculated as the mean value of the thresholds for 500, 1,000, 2,000, and 3,000 Hz. A paired-samples t-test was used for comparison of the preoperative and postoperative air and bone conduction hearing, thresholds and air-bone gaps.
   Results: Significant recovery was found in the postoperative air conduction threshold and air-bone gap in both the temporalis fascia and cartilage groups as compared to those before surgery (p < 0.001). However, the average air and bone conduction thresholds and air-bone gap were found to be statistically different after surgery in the cartilage group as compared to those in the temporalis fascia group. There was no significant difference in hearing parameters before and after, surgery in patients with or without mastoidectomy in either the cartilage group or the temporalis fascia group.
   Conclusions: The hearing gain in patients with cartilage shield grafting was better than that in those who had temporalis fascia tympanoplasty, although experimental analysis shows loss of acoustic energy for thick and large shield cartilage grafts.
C1 [Yetiser, Sertac] Anadolu Med Ctr, Dept Otorhinolaryngol Head & Neck Surg, TR-41400 Gebze, Turkey.
   [Hidir, Yusuf] Gulhane Mil Med Acad, Dept Otorhinolaryngol Head & Neck Surg, Etlik, Turkey.
RP Yetiser, S (reprint author), Anadolu Med Ctr, Dept Otorhinolaryngol Head & Neck Surg, TR-41400 Gebze, Turkey.
CR Anderson J, 2004, OTOL NEUROTOL, V25, P856, DOI 10.1097/00129492-200411000-00002
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   Bacciu S., 1998, Auris Nasus Larynx, V25, P155, DOI 10.1016/S0385-8146(98)00005-4
   BUCKINGHAM RA, 1992, ANN OTO RHINOL LARYN, V101, P755
   De Foer B, 2008, OTOL NEUROTOL, V29, P513, DOI 10.1097/MAO.0b013e31816c7c3b
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   Effat KG, 2005, J LARYNGOL OTOL, V119, P611
   Gerber MJ, 2000, LARYNGOSCOPE, V110, P1994, DOI 10.1097/00005537-200012000-00002
   GYO K, 1992, Auris Nasus Larynx, V19, P75
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   LEVINSON RM, 1987, LARYNGOSCOPE, V97, P1069
   Mansour MH, 2006, J LARYNGOL OTOL, V120, P952
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   Zahnert T, 2000, AM J OTOL, V21, P322, DOI 10.1016/S0196-0709(00)80039-3
NR 19
TC 8
Z9 11
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD AUG
PY 2009
VL 118
IS 8
BP 570
EP 574
PG 5
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 484RP
UT WOS:000269065300007
PM 19746755
ER

PT J
AU Xu, W
   Han, DM
   Hu, HY
   Fan, EZ
AF Xu, Wen
   Han, Demin
   Hu, Huiying
   Fan, Erzhong
TI Characteristics of Experimental Recurrent Laryngeal Nerve Surgical
   Injury in Dogs
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE laryngeal electromyography; recurrent laryngeal nerve; vocal fold
   paralysis
ID ELECTROMYOGRAPHY; PARALYSIS
AB Objectives: We characterized various recurrent laryngeal nerve (RLN) injuries in dogs.
   Methods: Sixteen dogs were classified as having complete injuries (transection) or incomplete injuries (ligation, half-section, and crush). The characteristics of nerve injuries were evaluated by endoscopic examination, laryngeal electromyography (LEMG), and histopathologic examination at 0 to 12 months after the injury.
   Results: After the RLN injury, the average muscle fiber diameter and the average muscle bundle diameter of the affected muscles were decreased, and the average number of muscular cell nuclei per square inch increased. Fibrillation potentials were found I to 3 months after injury, and reinnervation potentials appeared 3 to 6 months after incomplete injury. For nerve transection and ligation, there was no reaction with LEMG instantly after injury involving vocal fold fixation. Vocal fold motion did not improve in members of the complete injury group, whereas all of the vocal folds in the members of the nerve ligation subgroup had limited activity in the later period. Various forms of vocal fold mobility were observed after injury in the half-section subgroup. Animals in the crush subgroup had normal EMG signals combined with abnormal LEMG signals with lower amplitudes after injury. Vocal fold fixation was not observed in this subgroup.
   Conclusions: We found the causes of nerve injury, in order of decreasing severity, to be transection, ligation, half-section, and crush.
C1 [Xu, Wen; Han, Demin; Hu, Huiying; Fan, Erzhong] Capital Med Univ, Dept Otorhinolaryngol Head & Neck Surg, Beijing Tongren Hosp, Beijing 100730, Peoples R China.
RP Han, DM (reprint author), Capital Med Univ, Dept Otorhinolaryngol Head & Neck Surg, Beijing Tongren Hosp, 1 Dongjiaominxiang, Beijing 100730, Peoples R China.
CR Carrat X, 2000, ANN OTO RHINOL LARYN, V109, P736
   Eckel HE, 2003, ANN OTO RHINOL LARYN, V112, P103
   Heaton JT, 2000, ANN OTO RHINOL LARYN, V109, P972
   Kimaid P A T, 2004, Electromyogr Clin Neurophysiol, V44, P371
   Kimura J, 2001, ELECTRODIAGNOSIS DIS, P346
   MU LC, 1991, LARYNGOSCOPE, V101, P699
   Shinners MJ, 2006, OTOLARYNG HEAD NECK, V134, P413, DOI 10.1016/j.otohns.2005.11.037
   Shiotani A, 2001, LARYNGOSCOPE, V111, P472, DOI 10.1097/00005537-200103000-00017
   Sittel C, 2001, ARCH OTOLARYNGOL, V127, P155
   Tessema B, 2008, ANN OTO RHINOL LARYN, V117, P604
   Woodson GE, 2007, ANN OTO RHINOL LARYN, V116, P57
   Xu W, 2007, ANN OTO RHINOL LARYN, V116, P576
NR 12
TC 2
Z9 3
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD AUG
PY 2009
VL 118
IS 8
BP 575
EP 580
PG 6
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 484RP
UT WOS:000269065300008
PM 19746756
ER

PT J
AU de Alarcon, A
   Brehm, SB
   Kelchner, LN
   Meinzen-Derr, J
   Middendorf, J
   Weinrich, B
AF de Alarcon, Alessandro
   Brehm, Susan Baker
   Kelchner, Lisa N.
   Meinzen-Derr, Jareen
   Middendorf, Janet
   Weinrich, Barbara
TI Comparison of Pediatric Voice Handicap Index Scores With Perceptual
   Voice Analysis in Patients Following Airway Reconstruction
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT 88th Annual Meeting of the American-Broncho-Esophagological-Association
CY MAY 01-02, 2008
CL Orlando, FL
SP Amer Broncho Esophagol Assoc
DE CAPE-V; cricotracheal resection; dysphonia; laryngotracheoplasty;
   Pediatric Voice Handicap Index; quality of life; subglottic stenosis;
   voice
ID QUALITY-OF-LIFE; LARYNGOTRACHEAL RECONSTRUCTION; VOCAL QUALITY;
   LARYNGEAL RECONSTRUCTION; CHILDREN; VALIDATION; OUTCOMES; STENOSIS
AB Objectives: We performed a retrospective review to compare a subjective parental proxy-derived voice handicap survey to an observer-derived method of measuring voice perturbation in children who have undergone airway reconstruction. The main outcome measures were the Pediatric Voice Handicap Index (pVHI) total score and the Overall Severity score on the Consensus Auditory-Perceptual Evaluation of Voice (CAPE-V).
   Methods: The percent Overall Severity CAPE-V score (score divided by 100) and the percent pVHI score (score divided by 92) were calculated. A Wilcoxon signed rank test was used to compare CAPE-V scores with the pVHI total scores. The relationship between the pVHI scores and the CAPE-V scores was investigated with a Spearman correlation. Subgroup analysis was performed to determine the relationship of surgery type to CAPE-V and pVHI scores.
   Results: Fifty subjects with a history of airway surgery who were evaluated between 2005 and 2008 were identified, Forty-two of the 50 Subjects had complete data for review. Their median age was 7.1 years (range, 3.3 to 17.9 years). Their pVHI total scores had a median of 30 (range, I to 80). Their Overall Severity CAPE-V scores had a median of 50.5 (range, 0 to 98). Their median CAPE-V percent was higher than their median pVHI percent (50.5% versus 32.6%; p = 0.0003). A weak correlation was found between the Overall Severity CAPE-V score and the pVHI total score (rho = 0.41; p = 0.0003). There was a trend toward higher Overall Severity CAPE-V scores in patients who underwent cricotracheal resection. The total number of airway surgeries was significantly correlated with the Overall Severity CAPE-V score (rho = 0.6; p < 0.0001) but not with the pVHI score.
   Conclusions: Children who undergo airway reconstruction often have a resulting voice disturbance that can affect their lives in multiple dimensions. The results of this study revealed a weak-to-fair correlation between the parent-reported pVHI total score and expert ratings of voice quality using the CAPE-V. In this patient population, both of these tools provided important information regarding the relationship of the severity of voice disturbance to its handicapping effects.
C1 [de Alarcon, Alessandro; Brehm, Susan Baker; Kelchner, Lisa N.; Meinzen-Derr, Jareen; Middendorf, Janet; Weinrich, Barbara] Cincinnati Childrens Hosp, Med Ctr, Div Pediat Otolaryngol, Ctr Pediat Voice Disorders, Cincinnati, OH 45229 USA.
   [de Alarcon, Alessandro] Cincinnati Childrens Hosp, Med Ctr, Aerodigest Sleep Ctr, Cincinnati, OH 45229 USA.
   [Brehm, Susan Baker; Kelchner, Lisa N.; Middendorf, Janet; Weinrich, Barbara] Cincinnati Childrens Hosp, Med Ctr, Dept Speech Pathol, Cincinnati, OH 45229 USA.
   [Meinzen-Derr, Jareen] Cincinnati Childrens Hosp, Med Ctr, Div Biostat & Epidemiol, Cincinnati, OH 45229 USA.
   [Kelchner, Lisa N.] Univ Cincinnati, Dept Commun Sci & Disorders, Cincinnati, OH USA.
   [Brehm, Susan Baker; Weinrich, Barbara] Miami Univ, Dept Speech Pathol & Audiol, Oxford, OH 45056 USA.
RP de Alarcon, A (reprint author), Cincinnati Childrens Hosp, Med Ctr, Div Pediat Otolaryngol, Ctr Pediat Voice Disorders, 3333 Burnet Ave,MLC 2018, Cincinnati, OH 45229 USA.
CR BAILEY CM, 1995, INT J PEDIATR OTORHI, V32, pS93, DOI 10.1016/0165-5876(94)01170-3
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NR 15
TC 7
Z9 7
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD AUG
PY 2009
VL 118
IS 8
BP 581
EP 586
PG 6
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 484RP
UT WOS:000269065300009
PM 19746757
ER

PT J
AU Azadarmaki, R
   Mirza, N
   Soliman, AMS
AF Azadarmaki, Roya
   Mirza, Natasha
   Soliman, Ahmed M. S.
TI Unilateral True Vocal Fold Synkinesis Presenting With Airway Obstruction
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT 88th Annual Meeting of the American-Broncho-Esophagological-Association
CY MAY 01-02, 2008
CL Orlando, FL
SP Amer Broncho Esophagol Assoc
DE larynx; synkinesis; stridor; vocal fold paralysis
ID LARYNGEAL SYNKINESIS
AB Objectives: We present a case series of 10 patients with unilateral true vocal fold paralysis who presented with airway obstruction.
   Methods: A retrospective review of the authors' patients at 2 institutions with unilateral true vocal fold motion impairment was carried out over a 10-year period. Of these, 10 patients were identified who presented with stridor and dyspnea as a result of synkinesis. Six cases were a result of thyroidectomy, 1 case resulted from recurrent laryngeal nerve section for spasmodic dysphonia, 1 case occurred after anterior cervical diskectomy and fusion, and in 2 cases no cause was identified.
   Results: Three patients underwent tracheotomy. Two patients underwent partial arytenoidectomy. Seven patients underwent botulinum toxin injection; 2 were treated with breathing therapy, and in 1 case breathing therapy was recommended. Seven patients underwent treatment with more than 1 method.
   Conclusions: Unilateral vocal fold paralysis may present with airway obstruction as a result of synkinesis. Treatment should be incremental and starts with breathing therapy and botulinum toxin injection. Partial arytenoidectomy or tracheotomy may be necessary for refractory cases.
C1 [Azadarmaki, Roya; Soliman, Ahmed M. S.] Temple Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, Philadelphia, PA 19140 USA.
   [Mirza, Natasha] Univ Penn, Dept Otolaryngol Head & Neck Surg, Philadelphia, PA 19104 USA.
RP Soliman, AMS (reprint author), Temple Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, 3400 N Broad St,Kresge W 102, Philadelphia, PA 19140 USA.
CR Benjamin B, 2003, ANZ J SURG, V73, P784, DOI 10.1046/j.1445-2197.2003.02799.x
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   Iroto I, 1968, Ann Otol Rhinol Laryngol, V77, P296
   Maronian NC, 2004, ANN OTO RHINOL LARYN, V113, P877
   Paydarfar JA, 2001, LARYNGOSCOPE, V111, P844, DOI 10.1097/00005537-200105000-00016
   Woo P, 2004, ANN OTO RHINOL LARYN, V113, P805
NR 10
TC 4
Z9 4
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD AUG
PY 2009
VL 118
IS 8
BP 587
EP 591
PG 5
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 484RP
UT WOS:000269065300010
PM 19746758
ER

PT J
AU Groblewski, JC
   Shah, RK
   Zalzal, GH
AF Groblewski, Jan C.
   Shah, Rahul K.
   Zalzal, George H.
TI Microdebrider-Assisted Supraglottoplasty for Laryngomalacia
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT 112th Annual Meeting of the
   American-Academy-of-Otolaryngology-Head-and-Neck-Surgery
CY SEP 21-24, 2008
CL Chicago, IL
SP Amer Acad Otolaryngol Head & Neck Surg
DE airway surgery; epiglottoplasty; laryngomalacia; stridor;
   supraglottoplasty
ID RECURRENT RESPIRATORY PAPILLOMATOSIS; CHILDREN; LASER
AB Objectives: We describe our series in the surgical treatment of laryngomalacia using a microdebrider.
   Methods: We performed a retrospective review of patients who underwent microdebrider-assisted supraglottoplasty for laryngomalacia between October 2004 and February 2008. Patients with neurologic conditions and secondary airway lesions were excluded. The main outcome measures included complications, pain, resolution of stridor, presence of aspiration, and need for revision surgery.
   Results: Twenty-eight patients underwent microdebrider-assisted supraglottoplasty. The mean age at diagnosis was 109 days, and the mean age at the time of the procedure was 182 days. Nineteen patients (68%) had gastroesophageal reflux at diagnosis. The average operative time was 35.7 minutes (range, 11 to 65 minutes). No intraoperative complications or device problems occurred. Two patients remained intubated after the procedure. One patient required a tracheotomy, and 1 patient underwent revision supralottoplasty. Three patients had aspiration that resolved. There was negligible pain from the procedure, as all patients immediately resumed a diet. All patients had immediate or eventual resolution of stridor.
   Conclusions: This is the largest series of patients who underwent microdebrider-assisted supralottoplasty for laryngomalacia. This procedure is relatively safe, with minimal pain, and effective in patients with laryngomalacia. Microdebrider-assisted supraglottoplasty is the method of choice for supraglottoplasty in our institution.
C1 [Groblewski, Jan C.; Shah, Rahul K.; Zalzal, George H.] George Washington Univ, Div Otolaryngol, Childrens Natl Med Ctr, Sch Med, Washington, DC 20010 USA.
RP Zalzal, GH (reprint author), George Washington Univ, Div Otolaryngol, Childrens Natl Med Ctr, Sch Med, 111 Michigan Ave NW, Washington, DC 20010 USA.
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NR 17
TC 7
Z9 9
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD AUG
PY 2009
VL 118
IS 8
BP 592
EP 597
PG 6
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 484RP
UT WOS:000269065300011
PM 19746759
ER

PT J
AU Zhang, Y
   Krausert, CR
   Kelly, MP
   Jiang, JJ
AF Zhang, Yu
   Krausert, Christopher R.
   Kelly, Michael P.
   Jiang, Jack J.
TI Typing Vocal Fold Vibratory Patterns in Excised Larynx Experiments Via
   Digital Kymography
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE digital kymography; mucosal wave; signal typing
ID NONLINEAR DYNAMIC-ANALYSIS; HIGH-SPEED VIDEOENDOSCOPY; STRANGE
   ATTRACTORS; AUTOMATIC METHOD; VIDEOKYMOGRAPHY; VIBRATIONS; MODEL;
   VOICES; CLASSIFICATION; PERTURBATION
AB Objectives: Signal typing is central to the understanding of vocal fold vibratory patterns. Digital kymography (DKG) allows the direct observation of vocal fold vibratory patterns, and therefore, using DKG for vibratory signal typing may provide a useful complement to traditional signal typing techniques.
   Methods: Video data collected from 20 larynges excised from mongrel dogs were observed with DKG in order to find examples of type 1 (nearly periodic), type 2 (subharmonic), and type 3 (aperiodic) vibratory patterns. The time series, frequency spectra, and correlation dimensions were calculated for each signal type.
   Results: The type 1 pattern showed a periodic time series of glottal edges and a discrete frequency spectrum. The type 2 vibratory pattern displayed a time series of alternating high- and low-amplitude waves and a frequency spectrum that included a subharmonic (F0/2) frequency component. Regular and symmetric vibratory patterns were observed in the type 1 and type 2 patterns. The type 3 vibratory pattern was characterized by an aperiodic time series of glottal edges, a broadband frequency spectrum, and irregular and asymmetric vibratory patterns. The correlation dimension estimates increased from type 1 to type 2 to type 3.
   Conclusions: Imaging with DKG demonstrated an ability to assign a signal type to various laryngeal vibrations. Signal typing techniques utilizing direct observation of the vocal folds could be useful in determining valid methods for the analysis of vocal fold vibrations.
C1 [Zhang, Yu; Krausert, Christopher R.; Kelly, Michael P.; Jiang, Jack J.] Univ Wisconsin, Dept Surg, Sch Med & Publ Hlth, Div Otolaryngol Head & Neck Surg, Madison, WI USA.
RP Jiang, JJ (reprint author), 1300 Univ Ave,5745 Med Sci Ctr, Madison, WI 53706 USA.
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   ZHANG Y, J VOICE IN PRESS
NR 36
TC 6
Z9 7
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD AUG
PY 2009
VL 118
IS 8
BP 598
EP 605
PG 8
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 484RP
UT WOS:000269065300012
PM 19746760
ER

PT J
AU Kishimoto, Y
   Hirano, S
   Suehiro, A
   Tateya, I
   Kanemaru, S
   Nakamura, T
   Ito, J
AF Kishimoto, Yo
   Hirano, Shigeru
   Suehiro, Atsushi
   Tateya, Ichiro
   Kanemaru, Shin-ichi
   Nakamura, Tatsuo
   Ito, Juichi
TI Effect of Exogenous Hepatocyte Growth Factor on Vocal Fold Fibroblasts
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT 89th Annual Meeting of the American-Broncho-Esophagological-Association
CY MAY 28-29, 2009
CL Phoenix, AZ
SP Amer Broncho Esophagol Assoc
DE gene expression; hepatocyte growth factor; vocal fold fibroblast
ID EXTRACELLULAR-MATRIX; CANINE MODEL; C-MET; GENE-EXPRESSION; LAMINA
   PROPRIA; RABBIT MODEL; IN-VITRO; CELLS; RAT; METALLOPROTEINASE-1
AB Objectives: We have previously demonstrated the therapeutic potential of hepatocyte growth factor (HGF) in the treatment of vocal fold scarring, although how exogenous HGF affects gene expression of endogenous HGF or extracellular matrix components in the vocal fold fibroblasts remains unclear. In this in vitro study, we aimed to clarify this aspect in order to better understand the effects of HGF on the vocal folds.
   Methods: Fibroblasts were obtained from the lamina propria of the vocal folds of 5 Sprague-Dawley rats and were cultured with HGF at concentrations of 100, 10, 1, and 0 ng/mL. The cells were collected on days 1, 3, and 7, and the expression of endogenous HGF, its receptor c-Met, transforming growth factor-beta 1 (TGF-beta 1), procollagen types I and III, and hyaluronic acid synthase (HAS)-1 and HAS-2 messenger RNAs (mRNAs) was examined by real-time reverse transcription-polymerase chain reaction.
   Results: The expression of endogenous HGF and HAS-1 mRNAs increased significantly when exogenous HGF was administered at a concentration of 1 ng/mL. On day 1, the expression of TGF-beta 1 and HAS-2 mRNAs increased si.-nificantly in response to 1 ng/mL HGF.
   Conclusions: Exogenous HGF triggered the up-regulation of endogenous HGF, TGF-beta 1, HAS-1, and HAS-2 mRNAs in vocal fold fibroblasts.
C1 [Hirano, Shigeru] Kyoto Univ, Grad Sch Med, Dept Otolaryngol Head & Neck Surg, Sakyo Ku, Kyoto 6068507, Japan.
   [Nakamura, Tatsuo] Kyoto Univ, Inst Frontier Med Sci, Dept Bioartificial Organs, Kyoto 6068507, Japan.
RP Hirano, S (reprint author), Kyoto Univ, Grad Sch Med, Dept Otolaryngol Head & Neck Surg, Sakyo Ku, Kyoto 6068507, Japan.
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NR 30
TC 10
Z9 10
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
EI 1943-572X
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD AUG
PY 2009
VL 118
IS 8
BP 606
EP 611
PG 6
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 484RP
UT WOS:000269065300013
PM 19746761
ER

PT J
AU Gurgel, RK
   Lund, G
   Gundlapalli, AV
AF Gurgel, Richard K.
   Lund, Glen
   Gundlapalli, Adi V.
TI Role of Otolaryngologists in Health Care for the Homeless
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT National Health Care for the Homeless Conference
CY JUN 01-04, 2005
CL Washington, DC
DE epidemiology; health care; homelessness; surgical specialty
ID URBAN
AB Objectives: This study describes the prevalence of head and neck disease in patients seen at an urban, federally qualified clinic for those experiencing homelessness and determines the need for otolaryngologists in providing health care for the homeless.
   Methods: All adult patient visits from 2000 to 2004 were reviewed for ICD-9 diagnostic codes representing otolaryngological diseases. Chart review was performed for patients referred to a volunteer otolaryngologist to confirm diagnoses and referrals.
   Results: During the study period, the clinic served 11,690 unique patients in 59,060 patient visits. Otolaryngological diagnoses accounted for 8,959 of these total visits (15.2%), 94% of which were managed by primary care providers. The most common diagnoses were "upper respiratory infections," "symptoms, signs, and ill-defined conditions of the head and neck, cough, dysphagia," "other diseases of upper respiratory tract," and "disorders of the ear/mastoid process." An on-site volunteer otolaryngologist provided consultation on 6% of all patients with otolaryngological diagnoses, averaging 108 consultations per year; 39 patients were subsequently referred to community specialists for surgery and audiology services.
   Conclusions: There is a small but significant need for otolaryngologists in providing health care for homeless individuals in an urban setting. The authors encourage otolaryngologists and homeless health-care clinics to establish a relationship for volunteer services.
C1 [Gundlapalli, Adi V.] Univ Utah, Sch Med, Dept Internal Med, Salt Lake City, UT USA.
   [Gurgel, Richard K.; Lund, Glen; Gundlapalli, Adi V.] Wasatch Homeless Hlth Care Inc, Salt Lake City, UT USA.
RP Gurgel, RK (reprint author), Univ Iowa, Dept Otolaryngol Head & Neck Surg, 200 Hawkins Dr, Iowa City, IA 52242 USA.
CR BREAKEY WR, 1989, JAMA-J AM MED ASSOC, V262, P1352, DOI 10.1001/jama.262.10.1352
   D'Amore J, 2001, ACAD EMERG MED, V8, P1051, DOI 10.1111/j.1553-2712.2001.tb01114.x
   DOBLIN BH, 1992, JAMA-J AM MED ASSOC, V267, P698, DOI 10.1001/jama.267.5.698
   Grant A. M., 2004, INT J EVIDENCE BASED, V2, P1
   GRANT R, 2000, AC HLTH SERV RES HLT, P17
   HIBBS JR, 1994, NEW ENGL J MED, V331, P304, DOI 10.1056/NEJM199408043310506
   Hwang SW, 2001, CAN MED ASSOC J, V164, P229
   Levy BD, 2004, NEW ENGL J MED, V350, P2329, DOI 10.1056/NEJMp038222
   Mandelberg JH, 2000, ACAD EMERG MED, V7, P637, DOI 10.1111/j.1553-2712.2000.tb02037.x
   Pearson DA, 2007, ANN EMERG MED, V50, P646, DOI 10.1016/j.annemergmed.2007.07.015
   Salit SA, 1998, NEW ENGL J MED, V338, P1734, DOI 10.1056/NEJM199806113382406
NR 11
TC 0
Z9 0
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD JUL
PY 2009
VL 118
IS 7
BP 471
EP 474
PG 4
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 470RV
UT WOS:000267998400001
PM 19708482
ER

PT J
AU Fletcher, AM
   Preston, TW
   Kuehn, DM
   Clark, ED
   Van Daele, D
   Hoffman, H
AF Fletcher, Aaron M.
   Preston, Todd W.
   Kuehn, David M.
   Clark, Eve D.
   Van Daele, Douglas
   Hoffman, Henry
TI Ultrasound-Guided Needle Localization of Recurrent Paratracheal Thyroid
   Cancer
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE localization; recurrence; thyroid cancel; ultrasound
ID ANCHOR-WIRE MARKING
AB Objectives: Ultrasound-guided needle localization techniques have been used to direct the resection of targeted axillary lymph nodes in the management of breast cancer. To date, there has been only one other description of this technique as a localization method to direct cancer resection in the neck. We offer further support for the broader application of this technique by reporting its use in the successful identification and resection of recurrent papillary thyroid cancer after a paratracheal node dissection failed to localize the cancer.
   Methods: We report a case and discuss the relevant literature regarding ultrasound-guided localization and resection of recurrent well-differentiated thyroid cancel.
   Results: We were able to achieve successful identification and resection of recurrent papillary thyroid cancer using this technique.
   Conclusions: This technique may be useful in the treatment of selected cases of recurrent thyroid cancer to increase the efficacy and safety of surgical resection.
C1 [Fletcher, Aaron M.; Preston, Todd W.; Van Daele, Douglas; Hoffman, Henry] Univ Iowa Hosp & Clin, Dept Otolaryngol, Iowa City, IA 52242 USA.
   [Kuehn, David M.; Clark, Eve D.] Univ Iowa Hosp & Clin, Dept Radiol, Iowa City, IA 52242 USA.
RP Hoffman, H (reprint author), 200 Hawkins Dr, Iowa City, IA 52242 USA.
CR American Cancer Society, 2008, CANC FACTS FIG
   Bryant JA, 2005, J LARYNGOL OTOL, V119, P627
   Smith BR, 2006, THYROID, V16, P109
   DUPREZ R, EUR J RADIO IN PRESS
   Kim MK, 2004, ARCH OTOLARYNGOL, V130, P1214, DOI 10.1001/archotol.130.10.1214
   Oruwari JUN, 2002, AM J SURG, V184, P307, DOI 10.1016/S0002-9610(02)00957-1
   Randolph GW, 2007, INT J RADIAT ONCOL, V69, pS92, DOI 10.1016/j.ijrobp.2007.06.027
   SHEMEN LJ, 1992, ARCH OTOLARYNGOL, V118, P1337
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   Zimmerman P, 2004, AM J SURG, V188, P92, DOI 10.1016/j.amjsurg.2003.11.037
NR 11
TC 0
Z9 0
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD JUL
PY 2009
VL 118
IS 7
BP 475
EP 478
PG 4
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 470RV
UT WOS:000267998400002
PM 19708483
ER

PT J
AU Blumin, JH
   Handler, EB
   Simpson, B
   Osipov, V
   Merati, AL
AF Blumin, Joel H.
   Handler, Ethan B.
   Simpson, Blake
   Osipov, Vladimir
   Merati, Albert L.
TI Dysplasia in Adults With Recurrent Respiratory Papillomatosis: Incidence
   and Risk Factors
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT Annual Meeting of the Middle Section of the Triological-Society
CY JAN 18-20, 2008
CL Chicago, IL
SP Triol Soc
DE cidofovir; dysplasia; laryngeal papilloma; voice
ID LARYNGEAL PAPILLOMA; INTRALESIONAL CIDOFOVIR; CANCER
AB Objectives: Recurrent respiratory papillomatosis (RRP) causes significant morbidity in laryngology. The incidence of dysplasia in adult patients with RRP has not been well described. In this study, the risk factors and incidence of RRP-associated dysplasia are investigated.
   Methods: Pathology specimens from patients with RRP overa 6-year period are reviewed, along with the patients' clinical and demographic information.
   Results: Fifty-two male and 21 female patients (mean, 50 years) with RRP were identified. Some degree of dysplasia was identified in 22 of 170 specimens (13%). Sixteen of the 73 patients (21.9%) were found to have dysplasia at some point during their clinical course. Although the patients with RRP-associated dysplasia were older (56.3 versus 48.3 years of a-e), this difference did not reach statistical significance (p < 0.09, unpaired mest). There was a male preponderance in both dysplastic (10 of 16; 62.5%) and non-dysplastic (42 of 57; 73%) cases. The mean number of operations for RRP was 2.4 for patients without dysplasia and 3.2 for those with dysplasia; there was no significant difference between the groups. Seven of the 16 patients with dysplasia (44%) and 22 of the 57 patients without dysplasia (39%) had a history of tobacco use (p < 0.77, Fisher's exact test).
   Conclusions: Dysplasia was discovered in more than 20% of adult patients with RRP studied over a 6-year period. Age, gender, tobacco history, and operative frequency were not identifiable risk factors for the presence of dysplasia.
C1 [Blumin, Joel H.; Handler, Ethan B.; Merati, Albert L.] Med Coll Wisconsin, Div Laryngol & Profess Voice, Dept Otolaryngol & Commun Sci, Milwaukee, WI 53226 USA.
   [Osipov, Vladimir] Med Coll Wisconsin, Dept Pathol, Milwaukee, WI 53226 USA.
   [Simpson, Blake] Univ Texas Hlth Sci Ctr San Antonio, Dept Otolaryngol Head & Neck Surg, San Antonio, TX 78229 USA.
RP Merati, AL (reprint author), Univ Washington, Dept Otolaryngol Head & Neck Surg, Sch Med, Box 356515,1959 NE Pacific St, Seattle, WA 98195 USA.
CR Bielamowicz S, 2002, LARYNGOSCOPE, V112, P696, DOI 10.1097/00005537-200204000-00019
   Bornstein Jacob, 2007, Harefuah, V146, P764
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   Dedo HH, 2001, LARYNGOSCOPE, V111, P1639, DOI 10.1097/00005537-200109000-00028
   Giuliani L, 2007, ANTICANCER RES, V27, P2697
   Guvenc MG, 2008, AURIS NASUS LARYNX, V35, P357, DOI 10.1016/j.anl.2007.08.006
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   Jurkiewicz Dariusz, 2006, Pol Merkur Lekarski, V21, P94
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   Lee LA, 2008, LARYNGOSCOPE, V118, P50, DOI 10.1097/MLG.0b013e318155a288
   Pransky SM, 2003, LARYNGOSCOPE, V113, P1583, DOI 10.1097/00005537-200309000-00032
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   Werner R.D., 2005, ANN OTO RHINOL LARYN, V114, P836
NR 14
TC 16
Z9 17
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD JUL
PY 2009
VL 118
IS 7
BP 481
EP 485
PG 5
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 470RV
UT WOS:000267998400004
PM 19708485
ER

PT J
AU Jang, YJ
   Kim, JM
   Yeo, NK
   Yoo, JH
AF Jang, Yong Ju
   Kim, Jun Mo
   Yeo, Nam-Kyung
   Yoo, Ji Hoon
TI Use of Nasal Septal Bone to Straighten Deviated Septal Cartilage in
   Correction of Deviated Nose
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE bony septum; deviated nose; perpendicular plate; rhinoplasty; septal
   bone graft; vomer
ID CROOKED NOSE; GRAFTS; RECONSTRUCTION; MANAGEMENT; SURGERY
AB Objectives: Septoplasty for correction of deviated nose often requires removal of the deviated part of the quadrangular cartilage and the perpendicular plate of the ethmoid bone or vomer. In most cases, the removed bone is discarded. We describe our experience using septal bone for deviated nose correction, and analyze the postoperative results.
   Methods: A retrospective study was performed on 23 patients who underwent correction of deviated nose using nasal septal bone to straighten deviated septal cartilage from January 2004 to August 2008. The subjective satisfaction of patients was evaluated 6 to 12 months after rhinoplasty with a questionnaire. Aesthetic outcomes were evaluated by 2 independent rhinoplastic surgeons who compared preoperative and postoperative photographs. To evaluate outcomes objectively, we made anthropometric measurements of the deviated nose before and after surgery using facial photographs.
   Results: All patients indicated cosmetic satisfaction and improvement in nasal obstruction. The outcome analysis by 2 independent rhinoplastic surgeons indicated that 13 patients had excellent, 5 patients had good, and 5 had fair outcomes. Anthropometric measurements of the deviated nose showed that both the curved deviated angles and the linear deviated angle had improved (p < 0.05).
   Conclusions: Use of nasal septal bone to straighten deviated septal cartilage appears to be feasible in corrective rhinoplasty, and may be particularly beneficial in cartilage-depleted patients. Key Words: bony septum, deviated nose, perpendicular plate, rhinoplasty, septal bone graft, vomer.
C1 [Jang, Yong Ju; Yeo, Nam-Kyung] Univ Ulsan, Coll Med, Asan Med Ctr, Dept Otolaryngol, Seoul 138736, South Korea.
   [Kim, Jun Mo; Yoo, Ji Hoon] Bundang Jesaeng Hosp, Daejin Med Ctr, Dept Otolaryngol, Songnam, South Korea.
RP Jang, YJ (reprint author), Univ Ulsan, Coll Med, Asan Med Ctr, Dept Otolaryngol, 388-1 Pungnap 2Dong, Seoul 138736, South Korea.
CR Bateman N, 2000, J LARYNGOL OTOL, V114, P514
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   DUPONT C, 1966, PLAST RECONSTR SURG, V38, P243, DOI 10.1097/00006534-196609000-00009
   Emsen IM, 2008, AESTHET PLAST SURG, V32, P266, DOI 10.1007/s00266-007-9108-4
   Erdem T, 2008, RHINOLOGY, V46, P56
   Foda HMT, 2005, PLAST RECONSTR SURG, V115, P406, DOI 10.1097/01.PRS.0000149421.14281.FD
   Gewalli F, 2008, J CRANIOFAC SURG, V19, P1225, DOI 10.1097/SCS.0b013e31818435aa
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NR 17
TC 10
Z9 10
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD JUL
PY 2009
VL 118
IS 7
BP 488
EP 494
PG 7
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 470RV
UT WOS:000267998400006
PM 19708487
ER

PT J
AU Chun, R
   Preciado, DA
   Zalzal, GH
   Shah, RK
AF Chun, Robert
   Preciado, Diego A.
   Zalzal, George H.
   Shah, Rahul K.
TI Utility of Bronchoscopy for Recurrent Croup
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT 23rd Annual Meeting of the American-Society-of-Pediatric-Otolaryngology
CY MAY 02-04, 2008
CL Orlando, FL
SP Amer Soc Pediat Otolaryngol
DE croup; laryngotracheal reconstruction; laryngotracheobronchitis;
   laryngotracheoplasty; subglottic stenosis
ID DIAGNOSIS; EPIGLOTTITIS; AIRWAY
AB Objectives: We performed a retrospective review to determine the utility of bronchoscopy in patients with recurrent croup (RC).
   Methods: Bronchoscopy was performed on 30 patients with a diagnosis of RC (age, 14 months to 13.9 years) over a 2-year period.
   Results: One third of the patients (33.3%) were found to have airway disorders, including subglottic stenosis (7), subglottic edema (2), and a subglottic cyst (1). Patients with RC who were less than 3 years of age were more likely to have an airway abnormality found on endoscopy (9 of 14 or 64.2%) than were those older than 3 years (1 of 16 or 6.2%; chi(2), p < 0.001). There was no statistically significant difference in abnormal findings 1) in patients with RC who had a history of prematurity or prior intubations (chi(2), p = 0.17 and p = 0.052, respectively); 2) between infectious and spasmodic croup (chi(2), p = 0.794); or 3) by number of croup episodes (chi(2), p = 0.300). Two patients required Surgical intervention (laryngotracheal reconstruction and marsupialization of a subglottic cyst).
   Conclusions: Of 30 patients who underwent bronchoscopy for RC, 33% had airway disorders - mostly children less than 3 years old. We suggest a higher index of suspicion for finding airway disorders in children less than 3 years old with RC and having a lower threshold for performing diagnostic bronchoscopy in this population.
C1 [Chun, Robert] Med Coll Wisconsin, Dept Pediat Otolaryngol, Milwaukee, WI 53226 USA.
   [Preciado, Diego A.; Zalzal, George H.; Shah, Rahul K.] George Washington Univ, Sch Med, Childrens Natl Med Ctr, Div Otolaryngol, Washington, DC USA.
RP Chun, R (reprint author), Med Coll Wisconsin, Dept Otolaryngol & Commun Sci, Childrens Hosp Clin Bldg,9000 W Wisconsin Ave,POB, Milwaukee, WI 53226 USA.
CR BAKER SR, 1979, J OTOLARYNGOL, V8, P494
   CRESSMAN WR, 1994, PEDIATR CLIN N AM, V41, P265
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   MYER CM, 1994, ANN OTO RHINOL LARYN, V103, P319
   Stroud RH, 2001, AM J OTOLARYNG, V22, P268, DOI 10.1053/ajot.2001.24825
   TAN AKW, 1992, J OTOLARYNGOL, V21, P48
   WALI EY, 1995, INT J PEDIATR OTORHI, V32, P223
NR 8
TC 11
Z9 11
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD JUL
PY 2009
VL 118
IS 7
BP 495
EP 499
PG 5
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 470RV
UT WOS:000267998400007
PM 19708488
ER

PT J
AU Robey, AB
   O'Brien, EK
   Richardson, BE
   Baker, JJ
   Poage, DP
   Leopold, DA
AF Robey, Ashley B.
   O'Brien, Erin K.
   Richardson, Brynn E.
   Baker, John J.
   Poage, David P.
   Leopold, Donald A.
TI The Changing Face of Paranasal Sinus Fungus Balls
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT 54th Annual Fall Meeting of the American-Rhinologic-Society
CY SEP 20, 2008
CL Chicago, IL
SP Amer Rhinol Soc
DE fungus ball; microbiology; mycetoma; ostial dilatation; paranasal sinus;
   radiographic change
ID DIAGNOSIS; SURGERY
AB Objectives: We describe the clinical, radiographic, and histopathologic characteristics of fungus balls.
   Methods: We per-formed a retrospective review of 24 consecutive patients with the diagnosis of a paranasal sinus fungus ball (mycetoma) from 2001 to 2008.
   Results: We found that 18 of the 24 primarily involved sinuses had bony thickening, and 13 of the 24 had notable dilatation of the ostium. Eleven of the 24 patients were found to have some degree of immunocompromise (from organ transplantation, diabetes, etc). The patient's immune status correlated with the type of fungus involved. (Mucor-like fungi were more common in immunocompetent patients, and aspergillus-like fungi were more common in immunocompromised patients.) Also, there was a predilection for immunocompetent patients to have dilatated ostia, whereas immunocompromised patients were more likely to have a nondilatated ostium (p = 0.0 19).
   Conclusions: Our series of paranasal sinus fungus balls defines a group of patients heretofore poorly described in the literature erature. Our data reveal an increased incidence in immunocompromised patients. We also found consistent radiographic patterns, correlations between immune status and the fungal pathogen, correlations between ostial enlargement and immune, status, and the presence of cranial nerve pareses. These represent new findings that merit further study.
C1 [Robey, Ashley B.; O'Brien, Erin K.; Richardson, Brynn E.; Leopold, Donald A.] Univ Nebraska, Med Ctr, Dept Otolaryngol Head & Neck Surg, Omaha, NE USA.
   [Baker, John J.] Univ Nebraska, Med Ctr, Dept Pathol, Omaha, NE USA.
   [Poage, David P.] Univ Nebraska, Med Ctr, Dept Radiol, Omaha, NE USA.
RP Robey, AB (reprint author), 981225 Nebraska Med Ctr, Omaha, NE 68198 USA.
CR Barnea M, 2008, BIOCHEM BIOPH RES CO, V367, P452, DOI 10.1016/j.bbrc.2007.12.158
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   deShazo RD, 1997, J ALLERGY CLIN IMMUN, V99, P475, DOI 10.1016/S0091-6749(97)70073-3
   Dhong HJ, 2000, AM J RHINOL, V14, P227, DOI 10.2500/105065800779954446
   Dufour X, 2006, MED MYCOL, V44, P61, DOI 10.1080/13693780500235728
   Dufour X, 2005, RHINOLOGY, V43, P34
   Epstein VA, 2008, OTOLARYNG CLIN N AM, V41, P497, DOI 10.1016/j.otc.2008.01.001
   Ferguson BJ, 2000, OTOLARYNG CLIN N AM, V33, P389
   Ferreiro JA, 1997, HEAD NECK-J SCI SPEC, V19, P481
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NR 13
TC 6
Z9 7
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD JUL
PY 2009
VL 118
IS 7
BP 500
EP 505
PG 6
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 470RV
UT WOS:000267998400008
PM 19708489
ER

PT J
AU Hydman, J
   Bjorck, G
   Persson, JKE
   Zedenius, J
   Mattsson, P
AF Hydman, Jonas
   Bjorck, Gunnar
   Persson, Jonas K. E.
   Zedenius, Jan
   Mattsson, Per
TI Diagnosis and Prognosis of Iatrogenic Injury of the Recurrent Laryngeal
   Nerve
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE calcium channel; electromyography; laryngoscopy; nimodipine; vocal fold
   palsy
ID VOCAL FOLD IMMOBILITY; FACIAL-NERVE; MOLECULAR-BASIS; CORD PARALYSIS;
   NIMODIPINE; REINNERVATION; ELECTROMYOGRAPHY; THYROIDECTOMY;
   REGENERATION; RECOVERY
AB Objectives: Following perioperative injury to a macroscopically intact recurrent laryngeal nerve (RLN), there are two possible intraneural injury types: 1) axonal injury, including disruption of axons, and 2) conduction block, only affecting the Schwarm cells and the nodes of Ranvier. In this study, it was hypothesized that the functional outcome after RLN injury may depend on the type of nerve injury.
   Methods: Fifteen patients with acute postoperative unilateral RLN paralysis were prospectively studied. Electrophysiological examination (laryngeal electromyography) was used to differentiate between the two types of nerve injury. Vocal fold motions were monitored by repeated laryngoscopy during the study period (up to 6 months). Three of the patients with axonal injury were treated with the regeneration-promoting agent nimodipine.
   Results: The patients with conduction block all recovered normal vocal fold motion, whereas patients with axonal injury within the nerve had a significantly worse Outcome. The 3 patients who were treated with nimodipine all recovered normal or near-normal vocal fold mobility despite the more severe axonal injury.
   Conclusions: In contrast to previous reports, our results show that laryngeal electromyography is a reliable tool for diagnosing nosing the type of injury within the injured RLN, making it possible to predict the functional outcome in these patients. On the basis of the results, a future randomized study on nimodipine treatment for RLN axonal injury is suggested.
C1 [Hydman, Jonas] Karolinska Univ Hosp, Karolinska Inst, Dept Clin Neurosci, Neurosurg Sect, S-17176 Stockholm, Sweden.
   [Zedenius, Jan] Karolinska Univ Hosp, Karolinska Inst, Dept Mol Med & Surg, S-17176 Stockholm, Sweden.
   [Bjorck, Gunnar] Karolinska Univ Hosp, Dept Otorhinolaryngol Head & Neck Surg, S-17176 Stockholm, Sweden.
RP Hydman, J (reprint author), Karolinska Univ Hosp, Karolinska Inst, Dept Clin Neurosci, Neurosurg Sect, S-17176 Stockholm, Sweden.
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NR 35
TC 11
Z9 12
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD JUL
PY 2009
VL 118
IS 7
BP 506
EP 511
PG 6
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 470RV
UT WOS:000267998400009
PM 19708490
ER

PT J
AU Kos, MP
   David, EF
   Mahieu, HF
AF Kos, Martijn P.
   David, Eric F.
   Mahieu, Hans F.
TI Endoscopic Carbon Dioxide Laser Zenker's Diverticulotomy Revisited
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE carbon dioxide laser; dysphagia; hypopharyngeal pouch; upper esophageal
   sphincter myotomy; Zenker's diverticulum
ID STAPLING DIVERTICULOTOMY; PHARYNGEAL POUCHES; MANAGEMENT; CO2-LASER;
   ESOPHAGODIVERTICULOSTOMY; PATHOGENESIS; PERFORATION
AB Objectives: We assessed the efficacy of endoscopic Zenker's diverticulotomy with the carbon dioxide (CO(2)) laser and Acuspot and compared it with the historical results of using a CO(2) laser without Acuspot and electrocautery diverticulotomy.
   Methods: Between 1976 and 2005, a total of 229 endoscopic Zenker's diverticulotomies in 189 patients were performed in our institution. Since 1995, micro-endoscopic diverticulotomy with the CO(2) laser and Acuspot (MEDCO(2)A) has been performed in 61 cases. Between 1984 and 1995, micro-endoscopic diverticulotomy with the CO(2) laser (MEDCO(2)) was performed in 113 cases. Before 1984, endoscopic diverticulotomy with electrocautery (EDE) was performed in 55 cases. All patients had radiologically proven Zenker's diverticula. We recorded preoperative and postoperative complaints of dysphagia, the frequency of recurrence in long-term follow-up, postoperative tube feeding, non-oral intake, days of admission, and complications.
   Results: After operation, dysphagia was absent in 84.6% of MEDCO(2)A cases, 78.4% of MEDCO(2) cases, and 72.0% of EDE cases. Repeat surgery was required in 13.0% of MEDCO(2)A cases, 19.6% of MEDCO(2) cases, and 24.3% of EDE cases. Five patients developed mediastinitis (2 MEDCO(2) cases and 3 EDE cases); none died as a consequence. In I patient, sqbamous cell carcinoma was found in the diverticulum.
   Conclusions: The technological improvement of the CO(2) laser with Acuspot has further increased the efficacy of its use over that of methods previously used in our institution. The results and complications rate are comparable to those reported for endoscopic stapler diverticulotomy in the literature.
C1 [Kos, Martijn P.; Mahieu, Hans F.] Free Univ Amsterdam, Med Ctr, Dept Otolaryngol Head & Neck Surg, Amsterdam, Netherlands.
   [David, Eric F.] Free Univ Amsterdam, Med Ctr, Dept Radiol, Amsterdam, Netherlands.
RP Kos, MP (reprint author), Waterland Hosp, Dept Otolaryngol, POB 250, NL-1440 AG Purmerend, Netherlands.
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NR 34
TC 5
Z9 5
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD JUL
PY 2009
VL 118
IS 7
BP 512
EP 518
PG 7
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 470RV
UT WOS:000267998400010
PM 19708491
ER

PT J
AU Zuliani, G
   Carlisle, M
   Duberstein, A
   Haupert, M
   Syamal, M
   Berk, R
   Du, W
   Coticchia, J
AF Zuliani, Giancarlo
   Carlisle, Michael
   Duberstein, Aaron
   Haupert, Michael
   Syamal, Mausumi
   Berk, Richard
   Du, Wei
   Coticchia, James
TI Biofilm Density in the Pediatric Nasopharynx: Recurrent Acute Otitis
   Media Versus Obstructive Sleep Apnea
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT 22nd Annual Meeting of the American-Society-of-Pediatric-Otolaryngology
CY APR 27-29, 2007
CL San Diego, CA
SP Amer Soc Pediat Otolaryngol
DE biofilm; nasopharynx; obstructive sleep apnea; recurrent acute otitis
   media
ID BACTERIAL BIOFILMS; TYMPANOSTOMY TUBES; DAY-CARE; ADENOIDECTOMY;
   EFFUSION; INFECTIONS; CHILDREN
AB Objectives: We compared the biofilm surface density of adenoids removed from children with recurrent acute otitis media (RAOM) to that of adenoids removed from children with a diagnosis of obstructive steep apnea (OSA).
   Methods: We performed a comparative microanatomic study of adenoid mucosa using scanning electron microscopy in patients with diagnoses of RAOM and OSA (27 female and 41 male; age range, 3 months to 15 years).
   Results: The adenoids removed from patients with RAOM had dense, mature biofilms covering nearly their entire mucosal surfaces. More specifically, the adenoids removed from patients with RAOM had an average of 93.53% of their mucosal surface covered, versus an average of 1.01% coverage on the adenoids removed from patients with OSA. These differences were statistically significant (p < 0.0001).
   Conclusions: The adenoids removed from patients with RAOM had almost their entire mucosal surface covered with biofilms, versus scant coverage for patients with OSA. Recurrent acute otitis media is notoriously resistant to antibiotic treatment, and aspirates of middle ear fluid repeatedly yield negative cultures. It is these properties that have led biofilms to become increasingly implicated in the pathogenesis of RAOM. Thus, the resistance of biofilms to antimicrobials, together with their planktonic shedding of organisms, may be an important mechanism in the development of RAOM.
C1 [Zuliani, Giancarlo; Carlisle, Michael; Duberstein, Aaron; Syamal, Mausumi; Coticchia, James] Wayne State Univ, Sch Med, Div Pediat Otolaryngol, Dept Otolaryngol, Detroit, MI 48201 USA.
   [Berk, Richard] Wayne State Univ, Sch Med, Dept Immunol & Microbiol, Detroit, MI 48201 USA.
   [Du, Wei] Wayne State Univ, Sch Med, Dept Pediat, Detroit, MI 48201 USA.
   [Haupert, Michael] Childrens Hosp Michigan, Dept Pediat Otolaryngol, Detroit, MI 48201 USA.
RP Coticchia, J (reprint author), Wayne State Univ, Sch Med, Div Pediat Otolaryngol, Dept Otolaryngol Head & Neck Surg, 540 E Canfield, Detroit, MI 48201 USA.
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NR 18
TC 14
Z9 16
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD JUL
PY 2009
VL 118
IS 7
BP 519
EP 524
PG 6
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 470RV
UT WOS:000267998400011
PM 19708492
ER

PT J
AU de Wolf, MJF
   Hol, MKS
   Mylanus, EAM
   Cremers, CWRJ
AF de Wolf, Maarten J. F.
   Hol, Myrthe K. S.
   Mylanus, Emmanuel A. M.
   Cremers, Cor W. R. J.
TI Bone-Anchored Hearing Aid Surgery in Older Adults: Implant Loss and Skin
   Reactions
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE BAHA; bone-anchored hearing aid; older adult; osseointegration; skin
   reaction; surgical technique
ID PENETRATING TITANIUM IMPLANTS; SIMPLIFIED SURGICAL TECHNIQUE; CHILDHOOD
   EAR ABNORMALITIES; OSSEOINTEGRATED IMPLANTS; PERCUTANEOUS IMPLANTS;
   TEMPORAL BONE; FOLLOW-UP; HISTOLOGIC-FINDINGS; CHILDREN; COMPLICATIONS
AB Objectives: We evaluated the clinical outcome measures of fixture loss and skin reactions in older-adult users of percutaneous bone-anchored hearing aids (BAHAs).
   Methods: We performed a retrospective analysis of 224 older adults (at least 60 years of age) who underwent implantation of 248 implants with the simplified Nijmegen Surgical technique between January 1995 and May 2007.
   Results: During a mean follow-up of 39 months (range, 0 to 144 months), 16 of the 248 implants were lost (6.5%). The causes were failed osseointegration in 9 cases, trauma in 6 cases, and implant loss in irradiated bone in I case. There were no losses due to infection. Implant loss was not significantly cot-related with age. In 40 implants (16.9%), severe skin reactions of Holgers grade 2 or more were observed. Skin revision Surgery was performed around 6 implants (2.4%). None of the patients had an 8.5-mm abutment to overcome severe skill reactions.
   Conclusions: The outcome of BAHA surgery in older adults was favorable. The rate of implant loss was comparable with that in the overall population of BAHA recipients. There were low risks of severe skin reactions or developing thick skin around the implant.
C1 [de Wolf, Maarten J. F.; Hol, Myrthe K. S.; Mylanus, Emmanuel A. M.; Cremers, Cor W. R. J.] Radboud Univ Nijmegen, Med Ctr, Dept Otorhinolaryngol, Donders Ctr Neurosci, NL-6500 HB Nijmegen, Netherlands.
RP de Wolf, MJF (reprint author), Radboud Univ Nijmegen, Med Ctr, Dept Otorhinolaryngol, Donders Ctr Neurosci, POB 9101, NL-6500 HB Nijmegen, Netherlands.
RI Mylanus, Emmanuel/D-2255-2010
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NR 47
TC 22
Z9 22
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD JUL
PY 2009
VL 118
IS 7
BP 525
EP 531
PG 7
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 470RV
UT WOS:000267998400012
PM 19708493
ER

PT J
AU Hasegawa, N
   Ishimoto, S
   Takazoe, M
   Tsunoda, K
   Fujimaki, Y
   Shiraishi, A
   Kinoshita, M
   Okada, K
AF Hasegawa, Naoko
   Ishimoto, Shin-ichi
   Takazoe, Masakazu
   Tsunoda, Koichi
   Fujimaki, Youko
   Shiraishi, Aiko
   Kinoshita, Makoto
   Okada, Kazunari
TI Recurrent Hoarseness Due to Inflammatory Vocal Fold Lesions in a Patient
   With Crohn's Disease
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE Crohn's disease; hoarseness; larynx; steroid therapy; ulceration
ID MANIFESTATIONS; LARYNX
AB Crohn's disease is a chronic inflammatory bowel disease characterized by discontinuous chronic inflammation that may affect virtually all organs, including the head and neck. Laryngeal involvement in Crohn's disease is very rare, and only 9 cases have been reported. All 9 patients complained of difficulty in breathing due to edema and ulceration from the larynx to the hypopharynx. The present patient was a 31-year-old woman who had experienced the intestinal symptoms of Crohn's disease starting 20 months earlier and complained of hoarseness, sore throat, and odynophagia. The hoarseness worsened gradually because of limited ulceration of the vocal fold without edema. We describe the first case in which limited ulceration occurred on the vocal fold without airway involvement.
C1 [Ishimoto, Shin-ichi] Social Insurance Cent Gen Hosp, Dept Otolaryngol, Shinjuku Ku, Tokyo 1690073, Japan.
   [Takazoe, Masakazu] Social Insurance Cent Gen Hosp, Div Gastroenterol, Tokyo 1690073, Japan.
   [Ishimoto, Shin-ichi; Tsunoda, Koichi] Natl Inst Sensory Organs, Dept Artificial Organs & Otolaryngol, Tokyo, Japan.
RP Ishimoto, S (reprint author), Social Insurance Cent Gen Hosp, Dept Otolaryngol, Shinjuku Ku, 3-22-1 Hyakunin Cho, Tokyo 1690073, Japan.
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NR 14
TC 0
Z9 0
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD JUL
PY 2009
VL 118
IS 7
BP 532
EP 535
PG 4
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 470RV
UT WOS:000267998400013
PM 19708494
ER

PT J
AU Hattori, R
   Shimizu, S
   Majima, Y
   Shimizu, T
AF Hattori, Reiko
   Shimizu, Shino
   Majima, Yuichi
   Shimizu, Takeshi
TI Prostaglandin E2 Receptor EP2, EP3, and EP4 Agonists Inhibit
   Antigen-Induced Mucus Hypersecretion in the Nasal Epithelium of
   Sensitized Rats
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE allergy; eosinophil; goblet cell; mucus hypersecretion; prostaglandin
   E2; rat
ID AIRWAY INFLAMMATION; CELL DEGRANULATION; DENDRITIC CELLS; IL-6
   PRODUCTION; MURINE MODEL; GUINEA-PIGS; E-2; LIPOPOLYSACCHARIDE; ASTHMA;
   PGE(2)
AB Objectives: Prostaglandin (PG) E2 is a potential anti-inflammatory mediator that attenuates airway inflammation. To elucidate the functions of the PGE2 receptors (EP1, EP2, EP3, and EP4) in allergic inflammation, we examined the in vivo effects of EP agonists on mucus hypersecretion and eosinophil infiltration in rat nasal epithelium.
   Methods: We induced hypertrophic and metaplastic changes in goblet cells in nasal epithelium of ovalbumin-sensitized rats by intranasal challenge with ovalbumin. The effects of subcutaneous injections of EP agonists on mucus production and eosinophil infiltration were examined.
   Results: The EP4 agonist (1 to 100 mu g/kg) dose-dependently inhibited ovalbumin-induced mucus production. The EP2 and EP3 agonists (100 mu g/kg) also significantly inhibited mucus production. The EP3 agonist inhibited antigen-induced eosinophil infiltration, whereas the EP1 agonist showed no effect. This suppression of mucus production by the EP4 agonist was only effective when the EP4 agonist was given in the effector phase; administration in the induction phase resulted in no effect.
   Conclusions: These results indicate that PGE2 acts as an anti-inflammatory mediator via the EP receptors of airways in allergic inflammation. Selective EP agonists may provide a new therapeutic strategy for airway mucus hypersecretion.
C1 [Hattori, Reiko; Majima, Yuichi] Mie Univ, Sch Med, Dept Otorhinolaryngol Head & Neck Surg, Tsu, Mie 514, Japan.
   [Shimizu, Shino; Shimizu, Takeshi] Shiga Univ Med Sci, Dept Otorhinolaryngol, Shiga 5202192, Japan.
RP Shimizu, T (reprint author), Shiga Univ Med Sci, Dept Otorhinolaryngol, Shiga 5202192, Japan.
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NR 29
TC 1
Z9 1
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD JUL
PY 2009
VL 118
IS 7
BP 536
EP 541
PG 6
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 470RV
UT WOS:000267998400014
PM 19708495
ER

PT J
AU Burns, JA
   Har-El, G
   Shapshay, S
   Maune, S
   Zeitels, SM
AF Burns, James A.
   Har-El, Gady
   Shapshay, Stanley
   Maune, Steffen
   Zeitels, Steven M.
TI Endoscopic Laser Resection of Laryngeal Cancer: Is It Oncologically
   Safe? Position Statement From the American Broncho-Esophagological
   Association
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT 88th Annual Meeting of the American-Broncho-Esophagological-Association
CY MAY 01-02, 2008
CL Orlando, FL
SP Amer Broncho Esophagol Assoc
DE cancer; endoscopy; glottis; larynx; supraglottis; surgery
ID SQUAMOUS-CELL CARCINOMA; QUALITY-OF-LIFE; EARLY GLOTTIC CANCER; VOCAL
   CORD CARCINOMA; SUPRAGLOTTIC LARYNGECTOMY; FOLLOW-UP; CLINICAL
   EXPERIENCE; EXCISIONAL BIOPSY; UNITED-STATES; SURGERY
AB The purpose of this report is to summarize the salient points made during a panel discussion at the 88th Annual Meeting of the American Broncho-Esophagological Association about the efficacy and oncological safety of endoscopic laser treatment of laryngeal cancer. Guidelines for endoscopic laser management of early glottic and supraglottic cancer, including contraindications for this treatment modality, are presented. On the basis of all Currently available data, the panel, which critically considered the question of oncological safety, is of the opinion that endoscopic laser resections are oncologically safe when applied judiciously and by a skilled oncological surgeon. Relative contraindications for endoscopic laser resection of laryngeal cancer include instances in which the whole tumor cannot be visualized; large tumors that require removing too much of the functional laryngeal unit, severely decreasing airway protection and leading to aspiration; and cartilage invasion. Specific contraindications for supraglottic cancer include bilateral arytenoid involvement and direct extension into the neck.
C1 [Burns, James A.; Zeitels, Steven M.] Massachusetts Gen Hosp, Ctr Laryngeal Surg & Voice Rehabil, Boston, MA 02114 USA.
   [Burns, James A.; Zeitels, Steven M.] Harvard Univ, Sch Med, Boston, MA USA.
   [Har-El, Gady] SUNY Downstate, Dept Otolaryngol Head & Neck Surg, Lenox Hill Hosp, New York, NY USA.
   [Shapshay, Stanley] Albany Med Coll, Div Otolaryngol, Albany, NY USA.
   [Maune, Steffen] Municipal Hosp, Dept Otolaryngol Head & Neck Surg, Cologne, Germany.
   [Maune, Steffen] Univ Kiel, Kiel, Germany.
RP Burns, JA (reprint author), Massachusetts Gen Hosp, Ctr Laryngeal Surg & Voice Rehabil, 1 Bowdoin Sq,11th Floor, Boston, MA 02114 USA.
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NR 53
TC 4
Z9 4
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD JUN
PY 2009
VL 118
IS 6
BP 399
EP 404
PG 6
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 457SD
UT WOS:000266952500001
PM 19663370
ER

PT J
AU Suehiro, A
   Hirano, S
   Kishimoto, Y
   Tanaka, S
   Ford, CN
AF Suehiro, Atsushi
   Hirano, Shigeru
   Kishimoto, Yo
   Tanaka, Shinzo
   Ford, Charles N.
TI Comparative Study of Vocal Outcomes With Silicone Versus Gore-Tex
   Thyroplasty
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT 89th Annual Meeting of the American-Broncho-Esophagological-Association
CY MAY 28-29, 2009
CL Phoenix, AZ
SP Amer Broncho Esophagol Assoc
DE Gore-Tex; silicone; thyroplasty; vocal outcome
ID MEDIALIZATION LARYNGOPLASTY; FOLD MEDIALIZATION; IMPLANT; PARALYSIS;
   ATROPHY
AB Objectives: We examined vocal outcomes of patients who underwent type I thyroplasty for unilateral vocal fold paralysis. Specifically, the vocal outcomes were compared between 15 patients whose thyroplasties were performed with silicone and 15 patients whose thyroplasties were performed with Gore-Tex.
   Methods: The examined clinical characteristics did not differ significantly between the groups. The vocal outcomes were evaluated by aerodynamic and acoustic measurements.
   Results: Aerodynamic examination indicated significant postoperative improvements in the maximum phonation time and mean flow rate in both groups. Shimmer was significantly improved only in the Gore-Tex group. A direct comparison between groups showed no significant difference in the degree of improvement of the vocal parameters, except for a significant improvement in the noise-to-harmonics ratio in the Gore-Tex group. The duration of surgery was significantly less in the Gore-Tex group than in the silicone group.
   Conclusions: Gore-Tex thyroplasty is considered to be comparable to silicone thyroplasty in terms of postoperative vocal outcomes. Gore-Tex thyroplasty enables a less invasive procedure with a shorter surgical duration and easier adjustment of medialization due to its flexibility.
C1 [Hirano, Shigeru] Kyoto Univ, Dept Otolaryngol Head & Neck Surg, Grad Sch Med, Sakyo Ku, Kyoto 6068507, Japan.
   [Tanaka, Shinzo] Osaka Red Cross Hosp, Dept Otolaryngol, Osaka, Japan.
   [Ford, Charles N.] Univ Wisconsin, Dept Surg, Div Otolaryngol Head & Neck Surg, Madison, WI USA.
RP Hirano, S (reprint author), Kyoto Univ, Dept Otolaryngol Head & Neck Surg, Grad Sch Med, Sakyo Ku, Kyoto 6068507, Japan.
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NR 13
TC 9
Z9 9
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD JUN
PY 2009
VL 118
IS 6
BP 405
EP 408
PG 4
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 457SD
UT WOS:000266952500002
PM 19663371
ER

PT J
AU Lopez-Escamez, JA
   Viciana, D
   Garrido-Fernandez, P
AF Lopez-Escamez, Jose A.
   Viciana, David
   Garrido-Fernandez, Pablo
TI Impact of Bilaterality and Headache on Health-Related Quality of Life in
   Meniere's Disease
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE Dizziness Handicap Inventory; migraine; outcome study; quality of life;
   recurrent vertigo; Short Form 36; vestibular system
ID SURVEY SF-36; HEARING; DISABILITY; TINNITUS; HANDICAP; VERTIGO; VERSION
AB Objectives: We analyzed the impact of bilaterality and headache on the health- related quality of life (HRQL) of patients with Meniere's disease (MD).
   Methods: A case series including 86 patients with a diagnosis of definite MD according to the American Academy of Otolaryngology-Head and Neck Surgery (AAO-HNS) diagnostic criteria was evaluated by the Short Form 36 (SF-36) Health Instrument and the Dizziness Handicap Inventory Short Form (DHI-S).
   Results: The scores on all scales of the SF-36 were significantly lower for bilateral MD than for unilateral cases, except for body pain. Both groups had scores worse than those of their sex- and age-matched normative population on all SF-36 scales (p = 0.017 to p = 0.0001), except for body pain in men. The DHI-S scores were also better for unilateral than for bilateral cases (p = 0.04), suggesting that the dizziness is perceived to be more disabling in bilateral MD. Migraine was significantly associated with bilateral MD (odds ratio, 3.58 [95% confidence interval, 1.25 to 10.31]; p = 0.021). Headache and score on the AAO-HNS functional scale, which evaluates the effect of vertigo attacks on daily activities, were two independent factors that explained a great part of the variability on all SF-36 scales, except for "role emotional" in bilateral MD.
   Conclusions: Patients with bilateral MD perceived their dizziness to be more disabling and had a worse HRQL than did patients with unilateral MD. Migraine was more frequently found in patients with bilateral involvement. Headache and score on the AAO-HNS functional scale were factors associated with the HRQL in bilateral MD.
C1 [Lopez-Escamez, Jose A.] Hosp Poniente Almeria, Otol & Neurotol Grp, Dept Otolaryngol, El Ejido 04700, Almeria, Spain.
   Torrecardenas Hosp, FIBAO, Almeria, Spain.
RP Lopez-Escamez, JA (reprint author), Hosp Poniente Almeria, Otol & Neurotol Grp, Dept Otolaryngol, CTS495,Ctra Almerimar S-N, El Ejido 04700, Almeria, Spain.
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NR 23
TC 8
Z9 8
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD JUN
PY 2009
VL 118
IS 6
BP 409
EP 416
PG 8
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 457SD
UT WOS:000266952500003
PM 19663372
ER

PT J
AU Laccourreye, O
   Seccia, V
   Menard, M
   Garcia, D
   Vacher, C
   Holsinger, FC
AF Laccourreye, Ollivier
   Seccia, Veronica
   Menard, Madeleine
   Garcia, Dominique
   Vacher, Christian
   Holsinger, F. Christopher
TI Extended Lateral Pharyngotomy for Selected Squamous Cell Carcinomas of
   the Lateral Tongue Base
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE conservation surgery; organ preservation; pharyngotomy; squamous cell
   carcinoma; tongue base
ID TRANSORAL LASER MICROSURGERY; TRANSPHARYNGEAL APPROACH; TRANSHYOID
   RESECTION; NECK DISSECTION; CANCER; CHEMORADIATION; THERAPY; TUMORS;
   RADIOTHERAPY; SURGERY
AB Objectives: In a retrospective review of an inception cohort of 26 patients with an isolated, previously untreated, moderately to well-differentiated invasive squamous cell carcinoma of the lateral tongue base, consecutively managed with an extended lateral pharyngotomy approach at a single tertiary referral care center, the authors review the key surgical points, highlight the potential technical pitfalls, and document the complications and long-term functional and oncological outcomes in terms of survival and local control.
   Methods: The adjunctive measures included induction chemotherapy, ipsilateral neck dissection, and postoperative radiotherapy, used in 96.1%, 96.1 %, and 38.5% of patients, respectively. All patients but 2 were followed for at least 5 years or until death (maximum, 158 months).
   Results: The significant postoperative complications included pharyngocutaneous fistula in 3 patients (11.5%) and hemorrhage requiring reoperation, partial flap necrosis, and pneumonia from aspiration in 1 patient (3.8%) each. In univariate analysis, no significant statistical relationship was noted between the significant postoperative complications noted and the variables under analysis. Overall, successful oral alimentation was achieved in 100% of patients by the first postoperative month without gastrostomy, tracheotomy, or completion total laryngectomy. There were no intraoperative or perioperative deaths. The main causes of death were metachronous second primary tumor, intercurrent disease, and distant metastasis, resulting in 84.6%, 64%, and 46.9% 1-, 3-, and 5-year Kaplan-Meier actuarial survival estimates, respectively. Two patients (7.6%) had local recurrence, resulting in 100%, 86.7%, and 86.7% 1-, 3-, and 5-year Kaplan-Meier actuarial local control estimates, respectively. As a function of T stage, the 3- and 5-year actuarial local control estimates were 100%, 87.5%, and 90.9% in patients with tumors classified as T1, T2, and T3-T4a, respectively.
   Conclusions: Such results suggest that extended lateral pharyngotomy should be integrated among the various conservative treatment options available to patients with selected carcinomas of the lateral tongue base.
C1 [Laccourreye, Ollivier; Seccia, Veronica; Menard, Madeleine; Garcia, Dominique; Holsinger, F. Christopher] Univ Paris 05, Dept Otorhinolaryngol Head & Neck Surg, HEGP, F-75270 Paris 06, France.
   [Vacher, Christian] Univ Paris 07, Dept Anat, Hosp Beaujon, AP HP, Paris, France.
RP Laccourreye, O (reprint author), AP HP, HEGP, Dept Otorhinolaryngol Head & Neck Surg, 20-40 Rue Leblanc, F-75015 Paris, France.
FU Progres 2000 Association
FX We are grateful to the Progres 2000 Association for its financial
   support and to the attending otorhinolaryngologist-head and neck
   surgeons (D. Brasnu, R. Cauchois. E. Chabardes, A. Fabre, S. Hans, V.
   Jouffre, and H. Laccourreye) who allowed us to use their charts in
   addition to the charts of Drs Menard and O. Laccourreye.
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NR 26
TC 1
Z9 1
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD JUN
PY 2009
VL 118
IS 6
BP 428
EP 434
PG 7
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 457SD
UT WOS:000266952500005
PM 19663374
ER

PT J
AU O'Malley, JT
   Burgess, BJ
   Jones, DD
   Adams, JC
   Merchant, SN
AF O'Malley, Jennifer T.
   Burgess, Barbara J.
   Jones, Diane D.
   Adams, Joe C.
   Merchant, Saumil N.
TI Techniques of Celloidin Removal From Temporal Bone Sections
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE cochlea; immunostaining; sodium hydroxide-methanol
ID INNER-EAR; EMBEDDING MEDIUM; PROTEINS; IMMUNOHISTOCHEMISTRY; COCHLEA
AB Objectives: We sought to determine whether the technique of celloidin removal influences the results of immunostaining in celloidin-embedded cochleae.
   Methods: We compared four protocols of celloidin removal, including those using clove oil, acetone, ether-alcohol, and methanol saturated with sodium hydroxide. By optimally fixing our tissue (perfused mice), and keeping constant the fixative type (formalin plus acetic acid), fixation time (25 hours), and decalcification time (ethylene(ethylenediaminetetraacetic acid for 7 days), we determined whether the technique of celloidin removal influenced the immunostaining results. Six antibodies were used with each removal method: prostaglandin D synthase, sodium, potassium adenosine triphosphatase (Na(+),K(+)-ATPase), aquaporin I, connective tissue growth factor, tubulin, and 200 kd neurofilament.
   Results: Clove oil, acetone, and ether-alcohol resulted in incomplete removal of the celloidin, thereby negatively affecting the results of immunostaining. The methanol-sodium hydroxide method was effective in completely removing the celloidin; it produced the cleanest and most reproducible immunostaining for all six antibodies.
   Conclusions: Freshly prepared methanol saturated with sodium hydroxide and diluted 1:2 with methanol was the best solvent for removing celloidin from Muse temporal bone sections, resulting in consistent and reproducible immunostaining with the six antibodies tested.
C1 [O'Malley, Jennifer T.; Burgess, Barbara J.; Jones, Diane D.; Adams, Joe C.; Merchant, Saumil N.] Massachusetts Eye & Ear Infirm, Dept Otolaryngol, Boston, MA 02114 USA.
   [Adams, Joe C.; Merchant, Saumil N.] Harvard Univ, Sch Med, Dept Otol & Laryngol, Boston, MA 02115 USA.
RP O'Malley, JT (reprint author), Massachusetts Eye & Ear Infirm, Dept Otolaryngol, 243 Charles St, Boston, MA 02114 USA.
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NR 18
TC 9
Z9 9
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD JUN
PY 2009
VL 118
IS 6
BP 435
EP 441
PG 7
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 457SD
UT WOS:000266952500006
PM 19663375
ER

PT J
AU Mesia, R
   Manos, M
   Nogues, J
   Galiana, R
   Garcia, MM
   Lozano, A
   Tornero, J
   Germa, JR
AF Mesia, Ricard
   Manos, Manel
   Nogues, Julio
   Galiana, Ramon
   Martinez Garcia, Maria
   Lozano, Alicia
   Tornero, Jordi
   Ramon Germa, Jose
TI Hyperfractionated Radiotherapy: Improvement of Survival in Locally
   Advanced Nasopharyngeal Carcinoma
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE hyperfractionated radiotherapy; induction chemotherapy; nasopharyngeal
   cancer; survival
ID COMPARING NEOADJUVANT CHEMOTHERAPY; PROGRESSION-FREE SURVIVAL;
   RANDOMIZED-TRIAL; PHASE-III; RADIATION-THERAPY; CONCURRENT CHEMOTHERAPY;
   ADJUVANT CHEMOTHERAPY; PLUS RADIOTHERAPY; METAANALYSIS; CISPLATIN
AB Objectives: Standard treatment with concomitant chemotherapy (CT) and radiotherapy (RT) for nasopharyngeal cancer has shown rates of locoregional control of 80% and has improved the rate of 5-year survival to 67% to 84%. Hyperfractionated radiotherapy (HFRT) may increase locoregional control of tumors of the head and neck, but the addition of concomitant CT involves an unacceptable level of toxicity. Adding induction CT may control distant metastasis. Here we compare the results of our protocol with induction CT followed by HFRT alone with the results obtained with concomitant treatments.
   Methods: Between October 1994 and May 2002, 46 patients with nasopharyngeal carcinoma were treated with HFRT. The patients with N+ or T4 lesions also received cisplatin-based induction CT (55%).
   Results: The patients received a mean of 3 CT cycles (range, 2 to 5). At 5 years, the rate of progression-free survival was 66% (range, 51.3% to 82.1%), and the global survival rate was 75.7% (range, 61.9% to 89.5%).
   Conclusions: The use of HFRT in association with induction CT in patients with the greatest risk of metastasis may be as effective as concomitant CT-RT for treatment of nasopharyngeal cancer. Efforts should now concentrate on minimizing the acute and chronic toxicities.
C1 [Manos, Manel; Nogues, Julio; Tornero, Jordi] Univ Barcelona, Dept Otorhinolaryngol, Hosp Univ Bellvitge, Barcelona 08907, Spain.
RP Manos, M (reprint author), Univ Barcelona, Dept Otorhinolaryngol, Hosp Univ Bellvitge, Feixa Ilarga S-N, Barcelona 08907, Spain.
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NR 22
TC 0
Z9 1
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD JUN
PY 2009
VL 118
IS 6
BP 442
EP 448
PG 7
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 457SD
UT WOS:000266952500007
PM 19663376
ER

PT J
AU Hunter, EJ
   Titze, IR
AF Hunter, Eric J.
   Titze, Ingo R.
TI Quantifying Vocal Fatigue Recovery: Dynamic Vocal Recovery Trajectories
   After a Vocal Loading Exercise
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE fatigue; recovery of function; vocal fold
ID LARYNGEAL MUSCLES; VOICE; TEACHERS; FOLD; BEHAVIORS; ENDURANCE;
   PRESSURE; SINGERS
AB Objectives: We quantified the recovery of voice following a 2-hour vocal loading exercise (oral reading).
   Methods: Eighty-six adult participants tracked their voice recovery using short vocal tasks and perceptual ratings after an initial vocal loading exercise and for the following 2 days.
   Results: Short-term recovery was apparent, with 90% recovery within 4 to 6 hours and full recovery at 12 to 18 hours. Recovery was shown to be similar to a dermal wound healing trajectory.
   Conclusions: The new recovery trajectory highlighted by the vocal loading exercise in the current Study is called a vocal recovery trajectory. By comparing vocal fatigue to dermal wound healing, this trajectory is parallel to a chronic wound healing trajectory (as opposed to an acute wound healing trajectory). This parallel suggests that vocal fatigue from the daily use of the voice could be treated as a chronic Wound, with the healing and repair mechanisms in a state of constant repair. In addition, there is likely a vocal fatigue threshold at which point the level of tissue damage would shift the chronic healing trajectory to an acute healing trajectory.
C1 [Hunter, Eric J.; Titze, Ingo R.] Denver Ctr Performing Arts, Natl Ctr Voice & Speech, Denver, CO USA.
   [Titze, Ingo R.] Univ Iowa, Dept Speech Pathol & Audiol, Iowa City, IA 52242 USA.
RP Hunter, EJ (reprint author), 1101 13th St, Denver, CO 80204 USA.
FU National Institute on Deafness and Other Communication Disorders [R01
   DC04224]
FX Funding for this work was provided by the National Institute on Deafness
   and Other Communication Disorders, grant numer R01 DC04224.
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NR 30
TC 14
Z9 15
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD JUN
PY 2009
VL 118
IS 6
BP 449
EP 460
PG 12
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 457SD
UT WOS:000266952500008
PM 19663377
ER

PT J
AU Wiikmann, C
   da Silva, MA
   Areas, EPG
   Tsuji, DH
   Sennes, LU
AF Wiikmann, Christian
   da Silva, Marcelo Alves
   Gomes Areas, Elizabeth Pinheiro
   Tsuji, Domingos Hiroshi
   Sennes, Luiz Ubirajara
TI Measurement of the Viscoelastic Properties of the Vocal Folds
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT 39th Brazilian Congress of Otorhinolaryngology
CY APR 02, 2008
CL Belo Horizonte, BRAZIL
DE larynx; rheology; rheometer; viscosity; vocal fold
ID SHEAR PROPERTIES; HYALURONIC-ACID; AUGMENTATION; MUCOSA; BIOMATERIALS;
   BIOMECHANICS; TISSUES; MATRIX; MODEL
AB Objectives: Studies of the viscoelastic properties of the vocal folds are normally performed with rheometers that use parallel assigned a fixed value. In tissues subject to variation of thickness plates whose interplate space is usually at between samples, fixed gaps could result in different compressions, compromising the comparison among them. We performed,in experimental study to determine whether different compressions call lead to different results in measurements of dynamic viscosity (DV) of vocal fold samples.
   Methods: We Measured the DV of vocal fold samples of 10 larynges of cadavers under 3 different compression levels, corresponding to 0.2, 0.5, and 10 N on an 8-mm-diameter parallel-plate rheometer.
   Results: The DV directly varied with compression. We observed statistically significant differences between the results of 0.2 and 10 N (p = 0.0396) and 0.5 and 10 N (p = 0.0442).
   Conclusions: The study demonstrated that the level of compression influences the DV measure and Suggests that a defined compression level should be used in rheometric studies of biological tissues.
C1 [Wiikmann, Christian; Tsuji, Domingos Hiroshi; Sennes, Luiz Ubirajara] Univ Sao Paulo, Fac Med, Disciplina Otorrinolaringol, Sao Paulo, Brazil.
   [da Silva, Marcelo Alves; Gomes Areas, Elizabeth Pinheiro] Univ Sao Paulo, Inst Quim, Lab Biofis Quim, Sao Paulo, Brazil.
RP Wiikmann, C (reprint author), Rua Cristiano Viana,671 Ap 151, BR-05411001 Sao Paulo, Brazil.
RI Sennes, Luiz/E-6815-2012; da Silva, Marcelo/G-2408-2012; Areas,
   Elizabeth/C-5566-2014; Institute of Chemistry - USP, Dept. of
   Chemistry/B-8988-2012
OI da Silva, Marcelo/0000-0002-1413-4021; 
CR Barnes H. A., 1989, INTRO RHEOLOGY
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NR 19
TC 4
Z9 4
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD JUN
PY 2009
VL 118
IS 6
BP 461
EP 464
PG 4
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 457SD
UT WOS:000266952500009
PM 19663378
ER

PT J
AU Shipchandler, TZ
   Lott, DG
   Lorenz, RR
   Friedman, AD
   Dan, O
   Strome, M
AF Shipchandler, Taha Z.
   Lott, David G.
   Lorenz, Robert R.
   Friedman, Aaron D.
   Dan, Olivia
   Strome, Marshall
TI New Mouse Model for Studying Laryngeal Transplantation
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE larynx; microvascular surgery; mouse; transplantation
ID IMMUNOSUPPRESSION; DONOR
AB Objectives: Laryngeal transplantation research has been Studied in various animal models. For in-depth, immunology-based transplantation research, however, a thoroughly studied animal model must exist. The purpose of this study was to develop a reliable surgical technique in mice to serve as a model for further Study of laryngeal transplantation.
   Methods: Heterotopic laryngeal transplantation was attempted in 15 immunocompetent mice by use of modifications of previously described techniques established in rats.
   Results: Various microvascular techniques were used that led to 8 Successful transplants (of 15) with patent vascularity at the time of sacrifice. The first 7 attempts at transplantation were unsuccessful because of technical difficulties related to vessel size, soft tissue traumatic injury, and venous congestion. Subsequently, 8 transplantation procedures were successfully performed after modifications of the Surgical technique.
   Conclusions: This Pilot Study describes the reproducible surgical techniques performed in using mice for studying laryngeal transplantation. Mice are cost-effective and immunologically well studied, and are thus ideal for further laryngeal transplantation research.
C1 [Shipchandler, Taha Z.; Lott, David G.; Lorenz, Robert R.; Friedman, Aaron D.; Dan, Olivia] Cleveland Clin, Head & Neck Inst, Cleveland, OH 44106 USA.
   [Strome, Marshall] Ctr Head & Neck Oncol, New York, NY USA.
RP Shipchandler, TZ (reprint author), 9500 Euclid Ave,A71, Cleveland, OH 44106 USA.
EM tshipchandler@hotmail.com
CR Birchall MA, 2002, BRIT J SURG, V89, P1470, DOI 10.1046/j.1365-2168.2002.02234.x
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   Lorenz RR, 2002, ANN OTO RHINOL LARYN, V111, P1120
   Nelson M, 2003, LARYNGOSCOPE, V113, P1308, DOI 10.1097/00005537-200308000-00009
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NR 7
TC 6
Z9 7
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD JUN
PY 2009
VL 118
IS 6
BP 465
EP 468
PG 4
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 457SD
UT WOS:000266952500010
PM 19663379
ER

PT J
AU Lahav, Y
   Burns, JA
   Feinberg, S
   Heaton, JT
   Zeitels, SM
AF Lahav, Yonatan
   Burns, James A.
   Feinberg, Steven
   Heaton, James T.
   Zeitels, Steven M.
TI Initial Anatomic Geographic Presentation of Glottal Dysplasia
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE dysplasia; hoarseness; keratosis; premalignant mucosa; vocal cord; vocal
   fold
ID KERATOSIS; LARYNX; PAPILLOMATOSIS; HYPERPLASIA; CARCINOMA; LASER
AB Glottal dysplasia is likely the most common laryngeal disease with a discernible lesion; however, investigations describing its initial anatomic geographic presentation are rare. To examine this, we identified 52 patients who did not have significant prior treatment or glottal cancer. Thirty-one patients had bilateral disease, so there were 83 vocal folds with precancerous dysplasia. The phonatory mucosa was the dominant disease site ill all; the epicenter was on the superior surface in 65 of the 83 folds and on the medial surface in 18 of the 83 folds. The arytenoid mucosa was involved in 8 of the 83 folds. Nineteen of the 52 patients had direct anterior-commissure involvement, and none had interarytenoid mucosal disease. The investigation established the commonly held principle that glottal dysplasia occurs primarily on phonatory mucosa. Given the frequent occurrence and recurrence of glottal dysplasia, treatment goals should focus on disease control to prevent malignant degeneration while preserving the subepithelial superficial lamina propria, necessary for phonatory mucosal pliability, vocal fold vibration, and optimal vocal function.
C1 Massachusetts Gen Hosp, Ctr Laryngeal Surg & Voice Rehabil, Boston, MA 02114 USA.
   Harvard Univ, Sch Med, Dept Surg, Boston, MA 02115 USA.
RP Zeitels, SM (reprint author), Massachusetts Gen Hosp, Ctr Laryngeal Surg, 1 Bowdoin Sq,11th Floor, Boston, MA 02114 USA.
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NR 16
TC 2
Z9 2
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD MAY
PY 2009
VL 118
IS 5
BP 321
EP 325
PG 5
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 445WW
UT WOS:000266083200001
PM 19548379
ER

PT J
AU Bartley, J
   Reid, D
   Morton, RP
AF Bartley, Jim
   Reid, David
   Morton, Randall P.
TI Prevalence of Vitamin D Deficiency Among Patients Attending a General
   Otolaryngology Clinic in South Auckland
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE 25-hydroxyvitamin D; otorhinolaryngology; South Auckland; vitamin D
ID OLDER
AB Objectives: We performed a prospective observational study to estimate the prevalence of vitamin D deficiency in patients attending a general otolaryngology clinic in South Auckland, New Zealand.
   Methods: From July 21, 2008, to August 7, 2008, all new patients presenting to otolaryngology clinics at which one of the authors (D.R.) was present had their vitamin D status assessed by measurement of their plasma 25-hydroxyvitamin D [25(OH)D] level.
   Results: Of 48 patients, 2% had 25(OH)D levels of 17.5 nmol/L or less (a level associated with osteomalacia), 58% had 25(OH)D levels of 50 nmol/L or less (a level associated with vitamin D deficiency), and 100% had 25(OH)D levels of 80 nmol/L or less.
   Conclusions: Most of the patients attending a general otolaryngology clinic in South Auckland are vitamin D-deficient. It is unclear whether low vitamin D levels are associated more directly with otolaryngological disorders or skin type, bet, cause the small size of this study and the broad range of conditions seen precluded a meaningful statistical analysis. Further research into the relationship of vitamin D to specific otolaryngological presentations is required.
C1 [Bartley, Jim; Reid, David; Morton, Randall P.] Counties Manukau Dist Hlth Board, Div Otolaryngol Head & Neck Surg, Auckland, New Zealand.
RP Bartley, J (reprint author), 10 Owens Rd, Auckland 1023, New Zealand.
EM jbartley@ihug.co.nz
CR Aloia JF, 2007, EPIDEMIOL INFECT, V135, P1095
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   LABPLUS ELECT HDB
   2006 CENSUS DATA
NR 18
TC 4
Z9 4
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD MAY
PY 2009
VL 118
IS 5
BP 326
EP 328
PG 3
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 445WW
UT WOS:000266083200002
PM 19548380
ER

PT J
AU Halmos, GB
   van der Laan, BFAM
   Dikkers, FG
AF Halmos, Gyorgy B.
   van der Laan, Bernard F. A. M.
   Dikkers, Frederik G.
TI Groningen Dilatation Tracheoscope in Treatment of Moderate Subglottic
   and Tracheal Stenosis
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE benign subglottic and tracheal stenosis; dilatation tracheoscopy
ID LARYNGOTRACHEAL STENOSIS; THYROTRACHEAL ANASTOMOSIS;
   WEGENERS-GRANULOMATOSIS; ENDOSCOPIC TREATMENT; MANAGEMENT; AIRWAY;
   RECONSTRUCTION; EXPERIENCE; LARYNGEAL; RESECTION
AB Objectives: We describe our experience with the Groningen Dilatation Tracheoscope (Karl Storz GmbH & Co, Tuttlingen, Germany) in treating benign subglottic and tracheal stenosis.
   Methods: We performed a retrospective survey from a medical record analysis of 26 patients with different origins of benign, grade II (Myer-Cotton) subglottic or tracheal stenosis. All patients underwent dilatation tracheoscopy for a total of 64 times (average, 2.46 operations per patient). Five patients had to undergo subsequent operations. Patient data (sex, age at intervention, underlying and other systemic diseases) and operation data (course, intraoperative and postoperative adverse events) were recorded. Analysis of the measured preoperative and postoperative peak flow values was performed.
   Results: The average predilatation and postdilatation peak flow values were 225 L/min and 331 L/min, respectively. Eighty percent of the patients (21 of 26) were successfully treated with 1 or more dilatation tracheoscopy interventions without supplementary treatment for the stenosis. There is only 1 tracheal cannula-dependent patient in the examined Population, making the overall success rate of our treatment 96%. No major intraoperative or postoperative complications were recorded.
   Conclusions: Dilatation tracheoscopy is a simple, relatively safe, and effective method in the treatment of benign subglottic or tracheal stenosis of various origins. The intervention is minimally invasive and is easily repeatable in case of restenosis.
C1 [Halmos, Gyorgy B.; van der Laan, Bernard F. A. M.; Dikkers, Frederik G.] Univ Groningen, Univ Med Ctr Groningen, Dept Otorhinolaryngol, NL-9700 RB Groningen, Netherlands.
RP Halmos, GB (reprint author), Univ Groningen, Univ Med Ctr Groningen, Dept Otorhinolaryngol, POB 30-001, NL-9700 RB Groningen, Netherlands.
RI van der Laan, Bernard/H-2420-2011
OI van der Laan, Bernard/0000-0002-5016-2871
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NR 23
TC 3
Z9 3
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD MAY
PY 2009
VL 118
IS 5
BP 329
EP 335
PG 7
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 445WW
UT WOS:000266083200003
PM 19548381
ER

PT J
AU Scherf, F
   Van Deun, L
   van Wieringen, A
   Wouters, J
   Desloovere, C
   Dhooge, I
   Offeciers, E
   Deggouj, N
   De Raeve, L
   Wuyts, FL
   Van de Heyning, P
AF Scherf, Fanny
   Van Deun, Lieselot
   van Wieringen, Astrid
   Wouters, Jan
   Desloovere, Christian
   Dhooge, Ingeborg
   Offeciers, Erwin
   Deggouj, Naima
   De Raeve, Leo
   Wuyts, Floris L.
   Van de Heyning, Paul
TI Three-Year Postimplantation Auditory Outcomes in Children With
   Sequential Bilateral Cochlear Implantation
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE audiometric results; bilateral cochlear implantation; pediatric
   implantation; speech recognition assessment
ID QUALITY-OF-LIFE; DEAF-CHILDREN; SPEECH-PERCEPTION; HEARING-AIDS; USERS;
   PERFORMANCE; AGE; ADULTS; COMMUNICATION; BENEFITS
AB Objectives: We report on the auditory abilities and speech performance in quiet and noise of 35 children with sequential bilateral cochlear implantation after 3 years of bilateral implant use.
   Methods: Testing was done in bilateral and both unilateral listening conditions. The assessments took place before the second implantation and at several time intervals after fitting. As different auditory tests were used, the children were categorized by their age at the second implantation: younger or older than 6 years.
   Results: The pure tone averages for the bilateral condition were significantly better than those for either unilateral condition after 12 months of bilateral implant use and remained so from that test interval onward. The speech recognition outcomes in quiet and noise also improved significantly for almost all children after 36 months, although a linear regression analysis showed a beneficial effect of younger age at first implantation on the speech-in-noise results.
   Conclusions: Bilateral cochlear implantation offered advantages to all children in comparison with the first implant even the children who received the second implant after the age of 6 years. Compared to the younger children, the older children needed a longer adjustment period to gain bilateral benefit. However, they obtained similar results after 2 years of bilateral implant use.
C1 [Scherf, Fanny; Wuyts, Floris L.; Van de Heyning, Paul] Univ Antwerp, Univ Antwerp Hosp, Dept Otorhinolaryngol, Edegem, Belgium.
   [Wuyts, Floris L.] Univ Antwerp, Univ Antwerp Hosp, Dept Phys, Div Biomed Phys, Edegem, Belgium.
   [Dhooge, Ingeborg] Univ Ghent, Dept Otorhinolaryngol, B-9000 Ghent, Belgium.
   [Deggouj, Naima] St Luc Clin Catholic Univ Louvain, Dept Otorhinolaryngol, Brussels, Belgium.
   [Offeciers, Erwin] St Augustinus Gen Hosp, Dept Otorhinolaryngol, Antwerp, Belgium.
   [Desloovere, Christian] Katholieke Univ Leuven Hosp, Dept Otorhinolaryngol, Louvain, Belgium.
   [Van Deun, Lieselot; van Wieringen, Astrid; Wouters, Jan] Catholic Univ Louvain, Dept Neurosci, B-3000 Louvain, Belgium.
   [De Raeve, Leo] Commiss Res & Dev Persons Auditory Handicaps, Hasselt, Belgium.
RP Scherf, F (reprint author), Univ Antwerp Hosp, ENT Dept, Wilrijkstr 10, B-2650 Edegem, Belgium.
RI Wouters, Jan/D-1800-2015
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NR 41
TC 18
Z9 19
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD MAY
PY 2009
VL 118
IS 5
BP 336
EP 344
PG 9
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 445WW
UT WOS:000266083200004
PM 19548382
ER

PT J
AU Magliulo, G
AF Magliulo, Giuseppe
TI Acquired Atresia of the External Auditory Canal: Recurrence and
   Long-Term Results
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE acquired atresia; canalplasty; external auditory canal; magnetic
   resonance imaging
ID MEDIAL MEATAL FIBROSIS; SURGICAL-TREATMENT; FIBROTIZING OTITIS;
   STENOSIS; MANAGEMENT; SURGERY
AB Objectives: I describe the clinical symptoms and signs of acquired atresia of the external auditory canal (EAC) and the technique used to manage it.
   Methods: Forty-one consecutive patients affected by acquired atresia of the EAC were assessed by OtOSCOPY, pure tone audiometry, computed tomography, and traditional and echo-planar diffusion-weighted magnetic resonance imaging. The anatomic and functional hearing results were evaluated.
   Results: At surgery for acquired atresia of the EAC, an EAC cholesteatoma was found in 3 of the 41 patients. Twenty-three of the 41 patients were followed for at least 5 years. Recurrence was seen in 9 of the 25 ears (36%) over the entire period of observation. Twenty-one, 23, and 22 of the patients had a normal or nearly normal contour and size of the ear canal at 6 months, 1 year, and 5 years, respectively. The results were similar for the air-bone gap.
   Conclusions: The main complication following Surgery was recurrence. There was recurrence at 6 months in 4 patients (16%). Recurrence was seen in 12% of the cases at the 5-year follow-up. similar findings were clear on evaluation of the hearing results. This result demonstrates that the surgical procedure, even when performed correctly, did not afford a stable, long-lasting outcome in a cohort of patients.
C1 [Magliulo, Giuseppe] Univ Roma La Sapienza, G Ferreri Dept Otorhinolaryngol Audiol & Phoniatr, Rome, Italy.
RP Magliulo, G (reprint author), Via Greggorio 7 80, I-00165 Rome, Italy.
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NR 30
TC 3
Z9 3
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD MAY
PY 2009
VL 118
IS 5
BP 345
EP 349
PG 5
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 445WW
UT WOS:000266083200005
PM 19548383
ER

PT J
AU Migirov, L
   Kronenberg, J
   Henkin, Y
AF Migirov, Lela
   Kronenberg, Jona
   Henkin, Yael
TI Self-Reported Listening Habits and Enjoyment of Music Among Adult
   Cochlear Implant Recipients
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE cochlear implant; enjoyment; listening habits; music; self-report
ID HEARING
AB Objectives: We sought to assess the associations between self-reported listening habits and enjoyment of music, and the following variables: age at implantation. gender, prelingual versus postlingual deafness, duration of deafness, duration of. cochlear implant (CI) use, type of CI, speech coding strategy, and speech perception abilities.
   Methods: A questionnaire on listening habits and enjoyment of music before the onset of deafness and after implantation was sent to 85 adult CI recipients who had been using the devices for at least 6 months.
   Results: Of the 53 responders, 39 (73.6%) listened to music after implantation. Listening to music was not significantly related to age at implantation, gender, duration of deafness, duration of Cl use, type of Cl device, speech coding strategy, or open-set speech perception abilities. The 14 nonlisteners were postlingually deafened. The ratings of enjoyment were the same for 22.6% of patients, improved for 26.4%, and worse for 50.9%. Only 2 of 13 patients who played a musical instrument and 14 of 24 patients who sang before the onset of deafness resumed their musical activities.
   Conclusions: Despite the decline in listening habits and in the enjoyment of music after cochlear implantation, most patients do listen to music. The changes in listening habits and enjoyment were not related to the selected background variables.
C1 [Migirov, Lela; Kronenberg, Jona] Sheba Med Ctr, Dept Otolaryngol Head & Neck Surg, IL-52621 Tel Hashomer, Israel.
   [Henkin, Yael] Sheba Med Ctr, Speech & Hearing Ctr, IL-52621 Tel Hashomer, Israel.
   [Henkin, Yael] Tel Aviv Univ, Sackler Fac Med, Dept Commun Disorders, IL-69978 Tel Aviv, Israel.
RP Migirov, L (reprint author), Sheba Med Ctr, Dept Otolaryngol Head & Neck Surg, IL-52621 Tel Hashomer, Israel.
CR BOOTHROY.A, 1968, J ACOUST SOC AM, V43, P362, DOI 10.1121/1.1910787
   Brockmeier SJ, 2007, EAR HEARING, V28, p49S, DOI 10.1097/AUD.0b013e3180315468
   Brockmeier SJ, 2002, COCHLEAR IMPLANTS - AN UPDATE, P459
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   EISENBERG LS, 1982, ANN OTO RHINOL LARYN, V91, P62
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   Mirza S, 2003, Cochlear Implants Int, V4, P85, DOI 10.1002/cii.68
   Tyler R S, 2000, Cochlear Implants Int, V1, P82, DOI 10.1002/cii.31
NR 14
TC 10
Z9 11
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD MAY
PY 2009
VL 118
IS 5
BP 350
EP 355
PG 6
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 445WW
UT WOS:000266083200006
PM 19548384
ER

PT J
AU Clift, JM
   Wong, RD
   Carney, GM
   Stavinoha, RC
   Boyev, KP
AF Clift, Julie M.
   Wong, Robert D.
   Carney, Gregory M.
   Stavinoha, Rose C.
   Boyev, K. Paul
TI Radiographic Analysis of Cochlear Nerve Vascular Compression
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE cochlear nerve; cochleovestibular nerve; magnetic resonance imaging;
   nerve compression syndrome; sensorineural hearing loss; unilateral
   hearing loss
ID INFERIOR CEREBELLAR ARTERY; MICROVASCULAR COMPRESSION; COCHLEOVESTIBULAR
   NERVE; HEMIFACIAL SPASM; CRANIAL NERVE; HEARING-LOSS; SYMPTOMS; LOOPS
AB Objectives: We analyzed whether radiographically demonstrated anterior inferior cerebellar artery (AICA) vascular compression of the cochleovestibular nerve in asymmetric hearing loss could be correlated to either the symptomatic ear or to cochlear nerve diameter.
   Methods: We undertook a retrospective case-control study in which patients were enrolled into a database if audiometry demonstrated asymmetry of 20 dB at one frequency, asymmetry of 10 dB at two frequencies, or a difference of 20% on word recognition scores. If AICA vascular contact was demonstrated on subsequent magnetic resonance imaging of the cerebellopontine angle, patients were included in the study. Patients with vestibular schwannoma or Meniere's disease were excluded. The AICA contact was graded by a blinded neuroradiologist according to criteria proposed by McDermott et al. The cross-sectional area of the cochlear nerve was measured.
   Results: Symptomatic ears could be correlated to a decreased cochlear nerve diameter, but not to the degree of AICA penetration into the internal auditory canal.
   Conclusions: AICA vascular compression of the cochleovestibular nerve does not appear to correlate to hearing loss or to cochlear nerve diameter. The finding of decreased cochlear nerve diameter in symptomatic ears implies an alternative mechanism for asymmetric hearing loss.
C1 [Clift, Julie M.; Wong, Robert D.; Stavinoha, Rose C.; Boyev, K. Paul] Univ S Florida, Dept Otolaryngol Head & Neck Surg, Tampa, FL 33612 USA.
   [Carney, Gregory M.] Univ S Florida, Dept Radiol, Tampa, FL 33612 USA.
RP Boyev, KP (reprint author), Univ S Florida, Dept Otolaryngol Head & Neck Surg, 12901 Bruce B Downs Blvd,MDC 73, Tampa, FL 33612 USA.
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NR 23
TC 2
Z9 3
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD MAY
PY 2009
VL 118
IS 5
BP 356
EP 361
PG 6
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 445WW
UT WOS:000266083200007
PM 19548385
ER

PT J
AU Amin, SM
   Maged, KHA
   Naser, AY
   Aly, BH
AF Amin, Sameh M.
   Maged, Khaled H. Abdel
   Naser, Ashraf Y.
   Aly, Balegh H.
TI Laryngopharyngeal Reflux With Sore Throat: An Ultrastructural Study of
   Oropharyngeal Epithelium
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE laryngopharyngeal reflux; oropharynx; sore throat; transmission electron
   microscopy
ID DILATED INTERCELLULAR SPACES; NORMAL ORAL-MUCOSA; HUMAN-PAPILLOMAVIRUS;
   ESOPHAGEAL EPITHELIUM; DISEASE; PREVALENCE; DNA
AB Objectives: We performed an electron microscopic ultrastructural study of oropharyngeal epithelium in patients with laryngopharyngeal reflux (LPR) and sore throat to evaluate whether dilatation of intercellular spaces could be traced at this level.
   Methods: The study included 20 patients with LPR and sore throat and 5 control subjects. The patients were subjected to upper gastrointestinal tract endoscopy and flexible pharyngolaryngoscopy. Oropharyngeal biopsy specimens were taken from the patients and controls for ultrastructural Study by transmission electron microscopy.
   Results: The entire group of patients with LPR showed dilatation of intercellular spaces essentially at the squamous basal and suprabasal levels in their oropharyngeal biopsy specimens, whereas none of the control subjects showed such a morphological marker.
   Conclusions: Dilatation of intercellular spaces as a morphological marker can be traced in patients with LPR and sore throat at the level of the oropharynx. This contributes to a better understanding of the pathophysiology of LPR. If this finding is confirmed in a large series, it will represent a cost-effective, relatively noninvasive method for diagnosis of LPR.
C1 [Aly, Balegh H.] El Minia Univ Hosp, ENT Dept, Fac Med, El Minia, Egypt.
   [Amin, Sameh M.] El Fayoum Univ, ENT Dept, Fac Med, Al Fayyum, Egypt.
   [Maged, Khaled H. Abdel] Ain Shams Univ, Fac Med, Dept Internal Med, Cairo, Egypt.
   [Naser, Ashraf Y.] Zagazig Univ, Dept Anat, Zagazig, Egypt.
RP Aly, BH (reprint author), El Minia Univ Hosp, ENT Dept, Horiya St, El Minia 61111, Egypt.
RI Naeem, ashraf/I-8989-2012; Naeem, Ashraf/K-3355-2014
OI Naeem, ashraf/0000-0002-9034-3749; 
CR Ali MES, 2008, CURR OPIN ALLERGY CL, V8, P28, DOI 10.1097/ACI.0b013e3282f3f44f
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NR 22
TC 5
Z9 5
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD MAY
PY 2009
VL 118
IS 5
BP 362
EP 367
PG 6
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 445WW
UT WOS:000266083200008
PM 19548386
ER

PT J
AU Ukpo, OC
   Pritchett, CV
   Lewis, JE
   Weaver, AL
   Smith, DI
   Moore, EJ
AF Ukpo, Odey C.
   Pritchett, Cedric V.
   Lewis, Jean E.
   Weaver, Amy L.
   Smith, David I.
   Moore, Eric J.
TI Human Papillomavirus-Associated Oropharyngeal Squamous Cell Carcinomas:
   Primary Tumor Burden and Survival in Surgical Patients
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE base of tongue; carcinoma; human papillomavirus; oropharyngeal
   carcinoma; tonsil
ID ORAL-CANCER; NECK; HEAD; INFECTION; HPV; STAGE
AB Objectives: We sought to determine whether the primary tumor burden in oropharyngeal squamous cell carcinoma is lower in tumors positive for human papillomavirus (HPV) or in tumors with a smoking- or alcohol-related cause.
   Methods: We retrospectively reviewed medical records of patients at our institution who had squamous cell carcinoma of the palatine tonsils, base of ton-Lie, soft palate, or pharynx from 1995 through 2006. The patients underwent primary surgical therapy. The main outcome measures were the HPV status of tumors and nodes and the survival rates (categorized by HPV status).
   Results: Of 102 treated patients, 48 (47.1%) had HPV-positive carcinomas. Primary tumor size was not significantly different between HPV-positive and HPV-negative tumors (median, 2.5 versus 2.0 cm; p = 0.43). Patients with HPV had a higher prevalence of neck nodal metastases (35% versus 11%; p = 0.003) and high-grade lesions (83% versus 64%; p 0.03).
   Conclusions: Primary tumor burden was not associated with HPV status. Patients with HPV-positive oropharyngeal squamous cell carcinomas had a higher prevalence of neck nodal metastases and high-grade lesions.
C1 [Ukpo, Odey C.; Pritchett, Cedric V.; Moore, Eric J.] Mayo Clin, Dept Otorhinolaryngol, Rochester, MN 55905 USA.
   [Lewis, Jean E.] Mayo Clin, Div Anat Pathol, Rochester, MN 55905 USA.
   [Weaver, Amy L.] Mayo Clin, Div Biostat, Rochester, MN 55905 USA.
   [Smith, David I.] Mayo Clin, Div Expt Pathol & Lab Med, Rochester, MN 55905 USA.
RP Moore, EJ (reprint author), Mayo Clin, Dept Otorhinolaryngol, 200 1st St SW, Rochester, MN 55905 USA.
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NR 20
TC 10
Z9 12
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD MAY
PY 2009
VL 118
IS 5
BP 368
EP 373
PG 6
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 445WW
UT WOS:000266083200009
PM 19548387
ER

PT J
AU Gross, M
   Eliashar, R
   Ben-Yaakov, A
   Weinberger, JM
   Maly, B
AF Gross, Menachem
   Eliashar, Ron
   Ben-Yaakov, Avraham
   Weinberger, Jeffrey M.
   Maly, Bella
TI Clinicopathologic Features and Outcome of the Oncocytic Variant of
   Papillary Thyroid Carcinoma
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE Hurthle cell; oncocyte; oxyphilic cell; papillary thyroid carcinoma;
   thyroid gland
ID HURTHLE CELL TUMORS; CLINICAL-SIGNIFICANCE; BRAF MUTATIONS; GLAND;
   ETIOPATHOGENESIS; EMPHASIS
AB Objectives: The purpose of this Study was to define the clinicopathologic features and outcome of the oncocytic variant of papillary thyroid carcinoma (OVPTC) with a review of the literature.
   Methods: Twenty-three patients with OVPTC over a 10-year period were studied. Demographic, clinical, and histopathologic features and Outcome data were analyzed retrospectively.
   Results: Seventeen women and 6 men, ages ranging from 20 to 76 years (95% confidence interval, 43.0 to 54.48), were studied. Cervical lymph node involvement was found in 43.4% of the patients. Most of the recurrences were associated with thyroid masses greater than 2 cm in diameter. Evaluation of the overall survival data by the Kaplan-Meier method revealed that most recurrences took place earlier than 30 months, and the majority of patients (74%) were well, with no evidence of disease, up to 78 months after the last treatment. All of the OVPTC cases presented as nonencapsulated tumors, and 78.2% demonstrated extrathyroid stromal invasion.
   Conclusions: OVPTC is a unique variant of papillary thyroid carcinoma that has distinctive clinicopathologic features. Since OVPTC is often associated with local invasion and may involve cervical lymph nodes, it may require more extensive surgery than classic papillary thyroid carcinoma.
C1 [Gross, Menachem; Eliashar, Ron; Ben-Yaakov, Avraham; Weinberger, Jeffrey M.] Hadassah Hebrew Univ, Med Ctr, Dept Otolaryngol Head & Neck Surg, IL-91120 Jerusalem, Israel.
   [Maly, Bella] Hadassah Hebrew Univ, Med Ctr, Dept Pathol, IL-91120 Jerusalem, Israel.
RP Gross, M (reprint author), Hadassah Hebrew Univ, Med Ctr, Dept Otolaryngol Head & Neck Surg, IL-91120 Jerusalem, Israel.
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NR 20
TC 3
Z9 3
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD MAY
PY 2009
VL 118
IS 5
BP 374
EP 381
PG 8
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 445WW
UT WOS:000266083200010
PM 19548388
ER

PT J
AU de Heer, AMR
   Huygen, PLM
   Collin, RWJ
   Oostrik, J
   Kremer, H
   Cremers, CWRJ
AF de Heer, Anne-Martine R.
   Huygen, Patrick L. M.
   Collin, Rob W. J.
   Oostrik, Jaap
   Kremer, Hannie
   Cremers, Cor W. R. J.
TI Audiometric and Vestibular Features in a Second Dutch DFNA20/26 Family
   With a Novel Mutation in ACTG1
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE ACTG1; DFNA20/26; gamma-actin; genetic hearing impairment; vestibular
   impairment
ID DOMINANT HEARING-LOSS; LATE-ONSET; IMPAIRMENT; DEAFNESS; LOCUS;
   DFNA2/KCNQ4; 17Q25; MAPS
AB Objectives: We analyzed the phenotype in a 5-generation DFNA20/26 family with a novel missense mutation in the ACTG1 gene (c.151G>A) and compared the findings to previous reports on DFNA20/26 families.
   Methods: Audiometric data were collected from the family members of a Dutch kindred with the novel ACTG1 mutation. Cross-sectional and/or longitudinal analyses were performed on pure tone and speech audiometry data of the mutation carriers. Age-related typical audiograms were constructed. Vestibular examination was performed in all mutation carriers.
   Results: Overall, high-frequency hearing impairment, most prominent at ages over 30 years, was observed with a progression rate of 1.1 to 2.1 dB/y, increasing with frequency. It ultimately resulted in residual hearing. Speech recognition scores remained good at given pure tone average (1, 2, and 4 kHz) levels. but were slightly poorer than those at similar levels in a group of patients with presbycusis. Vestibular examination did not reveal any consistent, statistically significant abnormalities.
   Conclusions: The audiometric phenotype of the Dutch DFNA20/26 family with a novel mutation in ACTG1 was largely consistent with previous reports oil DFNA20/26. Considerable variations were found in audio.-rain configurations within the family. This is the first known DFNA20/26 family that has experienced tinnitus.
C1 [de Heer, Anne-Martine R.; Huygen, Patrick L. M.; Collin, Rob W. J.; Oostrik, Jaap; Kremer, Hannie; Cremers, Cor W. R. J.] Radboud Univ Nijmegen, Med Ctr, Dept Otorhinolaryngol, NL-6500 HB Nijmegen, Netherlands.
RP de Heer, AMR (reprint author), Radboud Univ Nijmegen, Med Ctr, Dept Otorhinolaryngol, POB 9101, NL-6500 HB Nijmegen, Netherlands.
RI Kremer, Hannie/F-5126-2010; Collin, Rob/N-3575-2014
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NR 26
TC 6
Z9 6
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD MAY
PY 2009
VL 118
IS 5
BP 382
EP 390
PG 9
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 445WW
UT WOS:000266083200011
PM 19548389
ER

PT J
AU Nason, R
   Lee, DH
   Jung, JY
   Chole, RA
AF Nason, Robert
   Lee, Dona H.
   Jung, Jae Y.
   Chole, Richard A.
TI Radiographic and Micro-Computed Tomographic Imaging of
   Lipopolysaccharide-Mediated Bone Resorption
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE calvaria; cholesteatoma; chronic otitis media; micro-computed
   tomography; osteoclast; Pseudomonas aeruginosa
ID TOLL-LIKE RECEPTORS; SUPPURATIVE OTITIS-MEDIA; OSTEOCLAST
   DIFFERENTIATION; IN-VITRO; CHOLESTEATOMA; INNATE; LPS;
   TOLL-LIKE-RECEPTOR-4; MACROPHAGES; BACTERIA
AB Objectives: Chronic otitis media and cholesteatomas cause hearing loss as a result of bony erosion. This bone resorption is known to be more aggressive when cholesteatomas become infected. The most common organism isolated front both diseases is the gram-negative bacterium Pseudomonas aeruginosa. Lipopolysaccharide (LPS), a major virulence factor found in the gram-negative bacterial cell wall, is well known to incite inflammatory bone resorption. The mechanisms underlying this process, however, are poorly understood. In this study, we developed a Mouse model of calvarial osteolysis in which resorption was reliably imaged by plain radiography and micro-computed tomography (micro-CT).
   Methods: A inurine calvarial model was developed to study bone resorption induced by P aeruginosa LPS. Calvariae from wild-type and knockout mice used in this model were imaged by plain radiography and micro-CT.
   Results: A high degree of correlation between plain radiography and micro-CT was identified (R(2) = 0.8554). Furthermore, maximal LPS-induced bone resorption required functioning toll-like receptor (TLR) 2, TLR4, and myeloid differentiation factor 88 (MyD88).
   Conclusions: We have developed a successful model of inflammatory osteolysis in which plain radiography call reliably delineate induced bone resorption. In vivo, we have shown that P aeruginosa LPS signals via TLR2, as well as TLR4 through MyD88.
C1 [Nason, Robert; Lee, Dona H.; Jung, Jae Y.; Chole, Richard A.] Washington Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, St Louis, MO 63110 USA.
   [Chole, Richard A.] Washington Univ, Sch Med, Dept Mol Pharmacol, St Louis, MO 63110 USA.
   [Chole, Richard A.] Washington Univ, Sch Med, Cent Inst Deaf, St Louis, MO 63110 USA.
RP Chole, RA (reprint author), Washington Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, 660 S Euclid Ave,Campus Box 8115, St Louis, MO 63110 USA.
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NR 30
TC 3
Z9 4
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD MAY
PY 2009
VL 118
IS 5
BP 391
EP 396
PG 6
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 445WW
UT WOS:000266083200012
PM 19548390
ER

PT J
AU Bogaardt, H
   van Dam, D
   Wever, NM
   Bruggeman, CE
   Koops, J
   Fokkens, WJ
AF Bogaardt, Hans
   van Dam, Danielle
   Wever, Nienke M.
   Bruggeman, Caroline E.
   Koops, Johan
   Fokkens, Wytske J.
TI Use of Neuromuscular Electrostimulation in the Treatment of Dysphagia in
   Patients With Multiple Sclerosis
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE deglutition disorder; electrical stimulation; multiple sclerosis
ID ELECTRICAL-STIMULATION; MOTOR CORTEX; PENETRATION; ASPIRATION; SCALE
AB Objectives: We explored the possible effects of neuromuscular electrostimulation on the swallowing function of patients with multiple sclerosis and swallowing problems.
   Methods: Twenty-five patients (average age, 53.1 years; SD, 9.8 years) with multiple sclerosis and swallowing problems were treated for 3 weeks with 2 sessions per week of neuromuscular electrostimulation. The average time since the onset of multiple sclerosis was 16.5 years (SD, 10.2 years). Seventeen patients were examined with transnasal flexible endoscopy 1 week before treatment and 1 week after treatment.
   Results: After treatment, a significant decrease in pooling of saliva in the pyriform sinuses was seen in 6 patients (p 0.03), and significantly less aspiration during swallowing of thin liquids (p < 0.01) was seen in 9 patients. Overall, the 25 patients reported that their swallowing had improved (p < 0.01), and in 20% of the patients, it had become less strenuous. No adverse effects of the treatment were reported.
   Conclusions: Our study showed that the treatment of swallowing problems with neuromuscular electrostimulation in patients with multiple sclerosis in this sample was successful in the reduction of pooling of saliva and in the reduction of aspiration.
C1 [Bruggeman, Caroline E.; Koops, Johan] Nieuw Unicum Rehabil Ctr, Dept Speech Therapy, Zandvoort, Netherlands.
   [Bogaardt, Hans; van Dam, Danielle; Wever, Nienke M.; Fokkens, Wytske J.] Univ Amsterdam, Acad Med Ctr, Dept Otorhinolaryngol, NL-1100 DD Amsterdam, Netherlands.
RP Bogaardt, H (reprint author), Univ Amsterdam, Acad Med Ctr, Dept Otorhinolaryngol D2 313, Meibergdreef 9, NL-1100 DD Amsterdam, Netherlands.
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NR 28
TC 14
Z9 14
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD APR
PY 2009
VL 118
IS 4
BP 241
EP 246
PG 6
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 433TL
UT WOS:000265228600001
PM 19462842
ER

PT J
AU Rees, CJ
   Henderson, AH
   Belafsky, PC
AF Rees, Catherine J.
   Henderson, Arthur H.
   Belafsky, Peter C.
TI Postviral Vagal Neuropathy
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE dysphonia; hoarseness; larynx; neuropathy; postviral vagal neuropathy;
   reflux; throat clearing; vagal neuropathy
ID CHRONIC COUGH; ZOSTER; PARALYSIS
AB Objectives: Postviral vagal neuropathy (PVVN) is a clinical diagnosis characterized by laryngeal complaints initiated by an upper respiratory tract infection (URI). Little is known about the natural history of this disease, and only small case series have been reported. We describe the clinical presentation, symptoms, patient demographics, and natural history of PVVN.
   Methods: A cross-sectional survey of all patients with a diagnosis of PVVN from January 1, 2006, to December 31, 2006, was prospectively administered, detailing disease onset, type and duration of symptoms, demographics, and previous treatment. The Reflux Symptom Index, Voice Handicap Index, and laryngoscopic findings were collected for each patient.
   Results: Forty-four patients with PVVN were identified. The mean age (+/- SD) was 48 +/- 13 years, and 73% of the patients were female. The most common initial URI symptoms were cough (89%), nasal congestion (75%), and rhinorrhea (64%). Fifty-nine percent of the patients took antibiotics, and the mean time between symptom onset and presentation to the laryngologist was 83 127 weeks. The most common persistent symptoms were cough (52%), throat clearing (48%), dysphonia (41.5%), and vocal fatigue (43%). Fifty-seven percent of the patients consulted 3 or more physicians for their symptoms. The mean Voice Handicap Index was 13.4 +/- 10.3, and the mean Reflux Symptom Index was 17.7 +/- 11. Forty-nine percent of the patients had evidence of vocal fold paresis on strobovideolaryngoscopy.
   Conclusions: PVVN is a clinical entity characterized by a complex of laryngeal symptoms that begin after a URI. The symptoms include chronic Cough, excessive throat clearing, dysphonia, and vocal fatigue. Affected individuals are typically in their fifth decade of life and appear more likely to be women. Most patients have seen Multiple physicians, and the time to laryngologist referral is often delayed.
C1 [Henderson, Arthur H.; Belafsky, Peter C.] Univ Calif Davis, Sch Med, Ctr Voice & Swallowing, Sacramento, CA 95825 USA.
   [Rees, Catherine J.] Wake Forest Univ, Ctr Voice & Swallowing Disorders, Winston Salem, NC 27109 USA.
RP Belafsky, PC (reprint author), Univ Calif Davis, Sch Med, Ctr Voice & Swallowing, 2521 Stockton Blvd,Suite 7200, Sacramento, CA 95825 USA.
EM peterb@ucdvoice.org
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NR 18
TC 12
Z9 12
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD APR
PY 2009
VL 118
IS 4
BP 247
EP 252
PG 6
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 433TL
UT WOS:000265228600002
PM 19462843
ER

PT J
AU Shin, HW
   Ahn, Y
   Sung, MW
   Kim, KH
   Kwon, TK
AF Shin, Hyun-Woo
   Ahn, Youngjin
   Sung, Myung-Whun
   Kim, Kwang Hyun
   Kwon, Tack-Kyun
TI Measurement of Cross-Sectional Dimensions of the Cricoid Cartilage: A
   Computed Tomographic Study
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE cricoid cartilage; cross-sectional anatomy; implant; vocal fold
   paralysis
ID VOCAL FOLD PARALYSIS; THIN STRUCTURES; THICKNESS; DENSITY; CT; ACCURACY
AB Objectives: We measured the cross-sectional dimensions of the cricoid cartilage and degrees of ossification of the marrow space for designing a cricoid implant.
   Methods: We reviewed 100 age- and sex-matched neck computed tomography scans that were performed at Seoul National University Hospital from 2001 to 2005. Under a standardized computed tomography window setting, the height of the cricoid cartilage marrow and the thickness of the marrow space and the ossified inner and outer cortices were measured by one observer.
   Results: The mean height of the cricoid cartilage marrow was 13.6 mm (range, 5.5 to 20.5 mm) in women and 17.5 mm (range, 13.0 to 24.5 mm) in men. The mean thickness of the cricoid cartilage marrow was 3.17 mm (range, 1.22 to 4.75 mm) in women and 5.13 mm (range, 3.42 to 7.60 mm) in men. We also observed that women in general have a higher density of the cricoid marrow than men; 4 women and 1 man had a markedly denser marrow space. There were individual variations in size and density of the cricoid marrow.
   Conclusions: Human adult cricoid cartilages have Sufficient marrow space for cricoid implantation. Preoperative evaluation of the size and density of the cricoid marrow is recommended for individual application of the cricoid implant.
C1 [Shin, Hyun-Woo; Ahn, Youngjin; Sung, Myung-Whun; Kim, Kwang Hyun; Kwon, Tack-Kyun] Seoul Natl Univ, Coll Med, Dept Otorhinolaryngol Head & Neck Surg, Seoul 110744, South Korea.
RP Kwon, TK (reprint author), Seoul Natl Univ, Coll Med, Dept Otorhinolaryngol Head & Neck Surg, 101 Daehangno, Seoul 110744, South Korea.
RI Kwon, Tack-Kyun/J-5381-2012; Kim, Kwang Hyun/J-5385-2012
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NR 11
TC 2
Z9 2
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD APR
PY 2009
VL 118
IS 4
BP 253
EP 258
PG 6
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 433TL
UT WOS:000265228600003
PM 19462844
ER

PT J
AU Richter, GT
   Wootten, CT
   Rutter, MJ
   Thompson, DM
AF Richter, Gresham T.
   Wootten, Christopher T.
   Rutter, Michael J.
   Thompson, Dana M.
TI Impact of Supraglottoplasty on Aspiration in Severe Laryngomalacia
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE aspiration; dysphagia; epiglottoplasty; functional endoscopic evaluation
   of swallowing; laryngomalacia; supraglottoplasty; swallow study
ID ENDOSCOPIC EVALUATION; SURGICAL-MANAGEMENT; LARYNGEAL SENSATION; SILENT
   ASPIRATION; CHILDREN; DYSPHAGIA; ANOMALIES; INFANT; STROKE
AB Objectives: We examined the incidence and significance of aspiration in infants with severe laryngomalacia (LM) who undergo supraglottoplasty.
   Methods: We performed a 5-year retrospective review of a prospective database from 2 tertiary care pediatric institutions. The studied patients were 50 consecutive infants with severe LM who underwent supraglottoplasty (median age, 4.5 months) and functional endoscopic evaluation of swallowing (FEES) with or without laryngopharyngeal stimulation testing. The intervention was cold-knife microlaryngeal supraglottoplasty and reflux management. The main outcome measure was aspiration resolution.
   Results: Preoperative FEES identified laryngeal penetration in 44 infants (88%) with severe LM. Laryngeal penetration with aspiration beyond the vocal folds was noted in 36 infants (72%). Postoperative FEES (median follow-up, 3.8 months) indicated resolution of laryngeal penetration and aspiration in 36 (81.8%) and 3 1 (86.1%) of these patients, respectively. The 14 patients without preoperative aspiration showed no evidence of aspiration after supraglottoplasty. In patients with aspiration, the mean preoperative laryngopharyngeal stimulation test threshold was 8.45 mm Hg. This improved on average by 4.0 mm Hg after supraglottoplasty (paired t-test, p < 0.0001). Multiple medical comorbidities were present in the 5 patients who had persistent aspiration after supraglottoplasty, including congenital heart disease (all 5 patients), congenital syndromes (4 patients), neurologic disorders (2 patients), and a need for tracheostomy (2 patients).
   Conclusions: Laryngeal penetration and aspiration improve after cold-knife supraglottoplasty. Supraglottoplasty does not cause aspiration in patients who do not have preoperative aspiration. Supraglottoplasty may not improve aspiration in patients with multiple medical comorbidities.
C1 [Thompson, Dana M.] Mayo Eugenio Litta Childrens Hosp, Div Pediat Otolaryngol, Dept Otorhinolaryngol, Rochester, MN 55902 USA.
   [Richter, Gresham T.; Wootten, Christopher T.; Rutter, Michael J.; Thompson, Dana M.] Cincinnati Childrens Hosp, Med Ctr, Dept Pediat Otolaryngol, Cincinnati, OH USA.
RP Thompson, DM (reprint author), Mayo Eugenio Litta Childrens Hosp, Div Pediat Otolaryngol, Dept Otorhinolaryngol, 200 1st St SW, Rochester, MN 55902 USA.
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   Thompson DM, 2005, ANN OTO RHINOL LARYN, V114, P258
   Thomsen J, 2007, J ORG COMP ELECT COM, V17, P1
   Toynton SC, 2001, J LARYNGOL OTOL, V115, P35
   WILLGING JP, 1995, INT J PEDIATR OTORHI, V32, pS107, DOI 10.1016/0165-5876(94)01174-V
   ZALZAL GH, 1987, ANN OTO RHINOL LARYN, V96, P72
NR 27
TC 20
Z9 22
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD APR
PY 2009
VL 118
IS 4
BP 259
EP 266
PG 8
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 433TL
UT WOS:000265228600004
PM 19462845
ER

PT J
AU Tanna, N
   Choi, SS
AF Tanna, Neil
   Choi, Sukgi S.
TI Efficacy and Safety of Adenotonsillectomy for Pediatric Obstructive
   Sleep Apnea in Prader-Willi Syndrome
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE adenotonsillectomy; apnea; obstructive sleep apnea; pediatric sleep
   apnea; Prader-Willi syndrome
ID CHILDREN
AB Objectives: We performed a retrospective analysis in a tertiary care children's hospital to evaluate the efficacy and safety of adenotonsillectomy for the treatment of pediatric obstructive sleep apnea (OSA) in Prader-Willi syndrome (PWS).
   Methods: We studied all PWS patients who underwent adenotonsillectorny to treat OSA from January 1, 2004, to December 31, 2005. The main outcome measures were 1) preoperative and postoperative full overnight polysomnography and 2) postoperative complications.
   Results: Three PWS patients were identified, including female twins and 1 boy. All patients had preoperative evidence of OSA without central apnea. Resolution of OSA after adenotonsillectorny was variable. The patient with the highest body mass index and tonsil size had the least residual OSA after adenotonsillectomy. No perioperative complications or adverse events were observed.
   Conclusions: Adenotonsillectomy did not consistently improve OSA in this population of patients with PWS. No perioperative complications were noted. Postoperative polysomnography should be considered for evaluation of possible residual OSA, as additional interventions may be warranted.
C1 [Tanna, Neil; Choi, Sukgi S.] George Washington Univ, Dept Otolaryngol Head & Neck Surg, Washington, DC 20037 USA.
   [Choi, Sukgi S.] Childrens Natl Med Ctr, Dept Otolaryngol, Washington, DC 20010 USA.
RP Tanna, N (reprint author), George Washington Univ, Dept Otolaryngol Head & Neck Surg, 2150 Penn Ave NW,Suite 6-301, Washington, DC 20037 USA.
CR CASSIDY SB, 1990, DYSMORPHOL CLIN GENE, V4, P13
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   LIM J, 2003, COCHRANE DB SYST REV, V1, P3136
   Nixon GM, 2002, PEDIATR PULM, V34, P209, DOI 10.1002/ppul.10152
   Pavone M, 2006, PEDIATR PULM, V41, P74, DOI 10.1002/ppul.20334
   RICHARDS A, 1994, CLIN OTOLARYNGOL, V19, P193, DOI 10.1111/j.1365-2273.1994.tb01213.x
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NR 13
TC 7
Z9 7
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD APR
PY 2009
VL 118
IS 4
BP 267
EP 269
PG 3
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 433TL
UT WOS:000265228600005
PM 19462846
ER

PT J
AU Hsu, CM
   Armas, GL
   Su, CY
AF Hsu, Cheng-Ming
   Armas, Gian Luca
   Su, Chih-Ying
TI Marsupialization of Vocal Fold Retention Cysts: Voice Assessment and
   Surgical Outcomes
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE laryngoplasty; marsupialization; vocal fold cyst
ID STRAP MUSCLE TRANSPOSITION; MEDIALIZATION
AB Objectives: Although total excision remains the standard treatment for vocal fold retention cysts, postoperative deficits and damage to the vocal folds still occur. Marsupialization is a more conservative technique and can prevent these complications.
   Methods: In this prospective clinical series, 25 patients underwent the marsupialization procedure. Under a direct larynomicroscope, the cystic wall margin was retracted medially with microforceps. An incision was made with microscissors encircling the equator of the cyst. The cyst contents drained from the cystic cavity when the capsule was sectioned. For 7 patients with concomitant marked vocal fold atrophy, strap muscle transposition laryngoplasty was simultaneously performed.
   Results: All patients had complete preoperative and postoperative voice parameter analyses. A subjective improvement in voice quality was reported by 23 of the 25 patients (92%). A small recurrent vocal fold cyst was detected in I patient. Small vocal fold deficits and sulcus vocalis were detected in 2 and 4 patients, respectively. Only I patient described a worse voice after operation. No other complications were noted.
   Conclusions: Marsupialization of vocal fold retention cysts is a simple, relatively safe, and effective surgical treatment. Voice improvement, a low incidence of recurrence, and minimal vocal fold deficits demonstrate the validity of this technique. Marked preoperative vocal fold atrophy or postoperative glottal gap can be managed with medialization laryngoplasty.
C1 Chang Gung Mem Hosp, Dept Otolaryngol, Kaohsiung Med Ctr, Kaohsiung, Taiwan.
   Chang Gung Univ, Coll Med, Kaohsiung, Taiwan.
RP Su, CY (reprint author), Chang Gung Mem Hosp, Dept Otolaryngol, Kaohsiung Med Ctr, 123 Ta Pei Rd, Niao Sung Hsiang, Kaohsiung Hsien, Taiwan.
CR Altman KW, 2007, OTOLARYNG CLIN N AM, V40, P1091, DOI 10.1016/j.otc.2007.05.011
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   Shvero J, 2000, PATHOL RES PRACT, V196, P95
   Smith OD, 2000, INT J PEDIATR OTORHI, V52, P277, DOI 10.1016/S0165-5876(00)00277-9
   Su CY, 2005, LARYNGOSCOPE, V115, P528, DOI 10.1097/01.MLG.0000150091.55295.56
   Su CY, 2004, LARYNGOSCOPE, V114, P1106, DOI 10.1097/00005537-200406000-00028
   Su CY, 1999, LARYNGOSCOPE, V109, P1116, DOI 10.1097/00005537-199907000-00020
   Su CY, 2007, LARYNGOSCOPE, V117, P1153, DOI 10.1097/MLG.0b013e31805819a6
   Su CY, 2002, LARYNGOSCOPE, V112, P342, DOI 10.1097/00005537-200202000-00026
   Yamashita M, 2007, ANN OTO RHINOL LARYN, V116, P847
NR 13
TC 2
Z9 2
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD APR
PY 2009
VL 118
IS 4
BP 270
EP 275
PG 6
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 433TL
UT WOS:000265228600006
PM 19462847
ER

PT J
AU Lohuis, PJFM
   Tan, ML
   Bonte, K
   van den Brekel, MWM
   Balm, AJM
   Vermeersch, HB
AF Lohuis, Peter J. F. M.
   Tan, M. Liane
   Bonte, Katrien
   van den Brekel, Michiel W. M.
   Balm, Alfons J. M.
   Vermeersch, Hubert B.
TI Superficial Parotidectomy Via Facelift Incision
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE facelift; incision; parotidectomy
ID RHYTIDECTOMY; SURGERY
AB The stigma of a Visually prominent facial scar following parotid surgery can be distressing to a young patient. The surgical technique of parotidectomy via a facelift incision is described and evaluated. Thirty patients with a benign lesion of the parotid gland underwent a partial superficial parotidectomy via a modified facelift incision. After operation, all patients had excellent cosmesis and complete function of the facial nerve. The facelift incision provides adequate exposure of the parotid gland for (partial) superficial parotidectomy. It can be offered as an alternative to a select group of patients who present with a small, mobile tumor in the tail of the parotid gland and an explicit request for an invisible postoperative scar.
C1 [Lohuis, Peter J. F. M.; Tan, M. Liane; van den Brekel, Michiel W. M.; Balm, Alfons J. M.] Antoni Van Leeuwenhoek Hosp, Netherlands Canc Inst, Dept Head & Neck Oncol & Surg, NL-1066 CX Amsterdam, Netherlands.
   [Lohuis, Peter J. F. M.; van den Brekel, Michiel W. M.; Balm, Alfons J. M.] Univ Amsterdam, Acad Med Ctr, Dept Otorhinolaryngol, NL-1105 AZ Amsterdam, Netherlands.
   [Lohuis, Peter J. F. M.] Diakonessen Hosp, Dept Otorhinolaryngol Head & Neck Surg, Utrecht, Netherlands.
   [Lohuis, Peter J. F. M.; Bonte, Katrien; Vermeersch, Hubert B.] Ghent Univ Hosp, Dept Head & Neck Surg, B-9000 Ghent, Belgium.
RP Lohuis, PJFM (reprint author), Antoni Van Leeuwenhoek Hosp, Netherlands Canc Inst, Dept Head & Neck Oncol & Surg, Plesmanlaan 121, NL-1066 CX Amsterdam, Netherlands.
CR Appiani A, 1967, REV ARGENTINA CIRUGI, V21, P236
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   Jost G, 1999, AESTHET PLAST SURG, V23, P1, DOI 10.1007/s002669900234
   Marti-Pages C, 2007, INT J ORAL MAX SURG, V36, P72, DOI 10.1016/j.ijom.2006.09.008
   Murthy P, 1997, CLIN OTOLARYNGOL, V22, P206, DOI 10.1046/j.1365-2273.1997.00954.x
   Nouraei SAR, 2006, CLIN OTOLARYNGOL, V31, P531, DOI 10.1111/j.1365-2273.2006.01334.x
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   To EWH, 2000, BRIT J PLAST SURG, V53, P80
NR 12
TC 13
Z9 15
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD APR
PY 2009
VL 118
IS 4
BP 276
EP 280
PG 5
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 433TL
UT WOS:000265228600007
PM 19462848
ER

PT J
AU Suh, MW
   Kim, JS
   Koo, JW
AF Suh, Myung-Whan
   Kim, Ji Soo
   Koo, Ja-Won
TI Influence of Blood Pressure Manometer Feedback on the Parameters of the
   Vestibular Evoked Myogenic Potential Test
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE blood pressure monitor; electromyography; feedback method; response
   latency; vestibular evoked myogenic potential
AB Objectives: The objective of this study was to evaluate the merits of a blood pressure (BP) manometry feedback method for measurement of vestibular evoked myogenic potentials.
   Methods: Sixty ears of 30 normal volunteers were prospectively investigated. The vestibular evoked myogenic potentials were recorded under 3 different conditions: in the feedback-negative (FB-) condition, ie, in a sitting position without feedback; in the feedback-positive (FB+) condition, ie, in a sitting position with self-monitored BP feedback (using a BP cuff); and in a supine condition, ie, in a supine position without feedback. The interaural amplitude difference (IAD) ratios and interaural latency differences were analyzed.
   Results: The mean IAD ratio was smaller in the FB+ condition than in the FB- and supine conditions, but the difference was without statistical significance. The upper limits of the normal range of the IAD ratios were 39.5%, 18.3%, and 25.9% for the FB-, FB+, and supine conditions, respectively. The interaural latency difference of p 13 was significantly smaller in the supine condition than in the FB- and FB+ conditions.
   Conclusions: Although the reduction of the mean IAD ratio did not reach statistical significance by feedback monitoring in our study, feedback using a BP manometer may have some clinical significance, in that a more stable IAD ratio may be obtained with a narrower normal range and a smaller variation.
C1 [Suh, Myung-Whan; Koo, Ja-Won] Seoul Natl Univ, Bundang Hosp, Dept Otorhinolaryngol, Coll Med, Songnam 63707, Gyeonggi Do, South Korea.
   [Kim, Ji Soo] Seoul Natl Univ, Bundang Hosp, Dept Neurol, Coll Med, Songnam 63707, Gyeonggi Do, South Korea.
   [Suh, Myung-Whan] Dankook Univ, Coll Med, Dept Otolaryngol Head & Neck Surg, Cheonan, South Korea.
   [Koo, Ja-Won] Seoul Natl Univ, Med Res Ctr, Res Ctr Sensory Organs, Songnam 63707, Gyeonggi Do, South Korea.
RP Koo, JW (reprint author), Seoul Natl Univ, Bundang Hosp, Dept Otorhinolaryngol, Coll Med, Songnam 63707, Gyeonggi Do, South Korea.
RI Koo, Ja-Won/J-5376-2012; Kim, Ji-Soo/D-8744-2012
CR Cheng PW, 2003, EAR HEARING, V24, P195, DOI 10.1097/01.AUD.0000069225.80220.CB
   Murofushi T, 2001, ARCH OTOLARYNGOL, V127, P1069
   Murofushi T, 1996, ARCH OTOLARYNGOL, V122, P845
   Ochi K, 2001, LARYNGOSCOPE, V111, P522, DOI 10.1097/00005537-200103000-00025
   Ochi K, 2003, OTOLARYNG HEAD NECK, V129, P655, DOI 10.1016/S0194-5994(03)01578-X
   Sheykholeslami K, 2001, AURIS NASUS LARYNX, V28, P197, DOI 10.1016/S0385-8146(00)90091-9
   Sheykholeslami K, 2001, AURIS NASUS LARYNX, V28, P41, DOI 10.1016/S0385-8146(00)00091-2
   Streubel SO, 2001, ACTA OTO-LARYNGOL, P41
   Su HC, 2004, OTOL NEUROTOL, V25, P977, DOI 10.1097/00129492-200411000-00019
   Vanspauwen R, 2006, ACTA OTO-LARYNGOL, V126, P796, DOI 10.1080/00016480500527227
   Vanspauwen R, 2006, LARYNGOSCOPE, V116, P131, DOI 10.1097/01.mlg.0000187405.57567.ae
   Wang CT, 2006, EAR HEARING, V27, P376, DOI 10.1097/01.aud.0000224126.24604.db
   Young YH, 2004, HEARING RES, V198, P93, DOI 10.1016/j.heares.2004.06.011
   Young YH, 2002, LARYNGOSCOPE, V112, P509, DOI 10.1097/00005537-200203000-00019
NR 14
TC 3
Z9 3
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD APR
PY 2009
VL 118
IS 4
BP 281
EP 286
PG 6
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 433TL
UT WOS:000265228600008
PM 19462849
ER

PT J
AU Albera, R
   Dagna, F
   Lacilla, M
   Canale, A
AF Albera, Roberto
   Dagna, Federico
   Lacilla, Michelangelo
   Canale, Andrea
TI Equine Versus Bovine Pericardium in Transmeatal Underlay Myringoplasty
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE graft material; myringoplasty
ID TYMPANIC MEMBRANE; TYMPANOPLASTY; OVERLAY; GRAFT
AB Objectives: Many different grafting materials have been proposed in myringoplasty. The aim of this study was to evaluate the results obtained in transmeatal underlay myringoplasty using bovine and equine pericardium. The results were compared with those obtained by using autologous temporalis fascia.
   Methods: The study group consisted of 52 patients with tympanic perforation. Twenty-nine patients were randomly selected for treatment with bovine pericardium and 23 for equine pericardium. A group Of 14 patients was treated with autologous temporalis fascia.
   Results: Closure of the perforation was achieved in 19 of 29 patients (66%) treated with bovine pericardium, in 19 of 23 (83%) treated with equine pericardium, and in 13 of 14 (93%) treated with autologous fascia. The best functional results in patients who gained closure of the perforation were obtained by means of equine pericardium.
   Conclusions: The overall long-term tympanic Closure rate demonstrates that equine pericardium has a greater take rate than bovine pericardium. The results obtained are inferior to those obtained with autologous fascia, but this technique is less aggressive. The higher success rate with equine pericardium may be due to the fact that it is thinner and easier to handle and model than bovine pericardium.
C1 [Albera, Roberto; Dagna, Federico; Lacilla, Michelangelo; Canale, Andrea] San Giovanni Battista Hosp, Dept Otorhinolaryngol, Turin, Italy.
RP Dagna, F (reprint author), Via Cassini 75-8, I-10129 Turin, Italy.
CR ALBERA R, 1999, OTORINOLARINGOLOGIA, V49, P11
   Albera R, 2006, ANN OTO RHINOL LARYN, V115, P875
   Ayache S, 2003, OTOL NEUROTOL, V24, P158, DOI 10.1097/00129492-200303000-00007
   DELATORRE MC, 2000, ACTA OTORRINOLARINGO, V51, P101
   Fayad JN, 2003, LARYNGOSCOPE, V113, P1228, DOI 10.1097/00005537-200307000-00022
   Gerard JM, 2006, B-ENT, V2, P177
   HORDIJK GJ, 1982, J LARYNGOL OTOL, V96, P43, DOI 10.1017/S0022215100092215
   Montinaro A, 2007, J Neurosurg Sci, V51, P17
   PFALTZ CR, 1985, AM J OTOL, V6, P266
   Rizer FM, 1997, LARYNGOSCOPE, V107, P1, DOI 10.1097/00005537-199712001-00001
   Sato H, 2008, ANN THORAC CARDIOVAS, V14, P192
   Singh GB, 2006, J OTOLARYNGOL, V35, P408, DOI 10.2310/7070.2005.0033
   Singh M, 2003, J LARYNGOL OTOL, V117, P444
   VARTIAINEN E, 1993, AM J OTOL, V14, P301
   Vos JD, 2005, LARYNGOSCOPE, V115, P1599, DOI 10.1097/01.mlg.0000172042.73024.ad
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   Yung M, 2007, OTOL NEUROTOL, V28, P353, DOI 10.1097/mao.0b013e318030d384
NR 17
TC 2
Z9 2
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD APR
PY 2009
VL 118
IS 4
BP 287
EP 291
PG 5
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 433TL
UT WOS:000265228600009
PM 19462850
ER

PT J
AU Hoa, M
   Syamal, M
   Sachdeva, L
   Berk, R
   Coticchia, J
AF Hoa, Michael
   Syamal, Mausurm
   Sachdeva, Livjot
   Berk, Richard
   Coticchia, James
TI Demonstration of Nasopharyngeal and Middle Ear Mucosal Biofilms in an
   Animal Model of Acute Otitis Media
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE acute otitis media; biofilm; chinchilla; nasopharynx
ID INFLUENZA-A VIRUS; STREPTOCOCCUS-PNEUMONIAE; RESPIRATORY VIRUSES;
   BACTERIAL BIOFILMS; TRANSPORT FUNCTION; CILIARY ACTIVITY;
   EUSTACHIAN-TUBE; CHINCHILLA; CHILDREN; INFECTION
AB Objectives: We performed this study to determine the role of nasopharyngeal and middle ear (ME) biofilms in acute otitis media (AOM).
   Methods: Sixty female 6-month-old chinchillas, free of ME disease, were utilized. Experimental animals were inoculated with influenza A followed by Streptococcus pneumoniae 7 days later. Control animals were inoculated with Sorensen's phosphate buffer. Daily otoscopy and tympanometry was performed, and the animals were painlessly sacrificed on days 1, 2, 5, 8, and 14. All mucosae were harvested and prepared for scanning electron microscopy.
   Results: The ME inflammation, initially detected on day 2 after bacterial inoculation, peaked on day 8. Eight percent of the dually inoculated chinchillas displayed type B tympanograms, and 40% displayed type C. Otoscopic evaluation of tympanic membrane inflammation was rated from 0 to 4 (0 = normal and 4 = severe drainage and/or inflammation) according to an otoscopic grading system. Ten percent of the experimental chinchillas had a grade 2 score, 20% had grade 3, and 6.7% had grade 4. The controls demonstrated no abnormal tympanometric or otoscopic findings. Scanning electron microscopic imaging showed dense biofilms on 83% of the nasopharynges and 67% of the MEs on day 8 in the experimental animals. All animals with ME biofilms had biofilms in the nasopharynx. The controls did not demonstrate biofilm formation.
   Conclusions: The study parallels the natural pathogenesis of AOM in humans. The demonstration of mucosal biofilms in both the nasopharynx (58%) and the ME (47%) of animals with ME inflammation and/or infection lends further support to the importance of mucosal biofilms in the pathogenesis of AOM.
C1 [Hoa, Michael; Syamal, Mausurm; Sachdeva, Livjot; Coticchia, James] Wayne State Univ, Sch Med, Div Pediat Otolaryngol, Dept Otolaryngol Head & Neck Surg, Detroit, MI 48201 USA.
   [Berk, Richard] Wayne State Univ, Sch Med, Dept Immunol & Microbiol, Detroit, MI 48201 USA.
RP Coticchia, J (reprint author), Wayne State Univ, Sch Med, Div Pediat Otolaryngol, Dept Otolaryngol Head & Neck Surg, 540 E Canfield,5E UHC, Detroit, MI 48201 USA.
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NR 30
TC 25
Z9 29
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD APR
PY 2009
VL 118
IS 4
BP 292
EP 298
PG 7
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 433TL
UT WOS:000265228600010
PM 19462851
ER

PT J
AU Munoz-Pinto, D
   Whittaker, P
   Hahn, MS
AF Munoz-Pinto, Dany
   Whittaker, Peter
   Hahn, Mariah S.
TI Lamina Propria Cellularity and Collagen Composition: An Integrated
   Assessment of Structure in Humans
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE cell density; collagen fiber thickness; collagen type; lamina propria;
   vocal fold
ID HUMAN VOCAL FOLD; FIBERS; TISSUE; ACCUMULATION; QUANTITATION; MAMMALS;
   MUCOSA
AB Objectives: In this study, we quantitatively examined cell density, collagen types I and III, and regional variations in collagen fiber thickness and orientation in the human midmembranous vocal fold lamina propria (LP).
   Methods: Lamina propria samples were solubilized with proteinase K or with cyanogen bromide. Cell density was assessed in proteinase K digests by measuring DNA and normalizing it to tissue total protein. Collagen types I and III were quantified by enzyme-linked immunosorbent assay-based detection of collagen type-specific peptides generated by cyanogen bromide digestion. In addition, LP total collagen was determined by measuring sample hydroxyproline levels. Variations in collagen fiber thickness and orientation with LP region were evaluated by examining picrosirius red-stained LP sections with circularly polarized light.
   Results: The mean (+/- SEM) cell density in the LP and associated epithelium was approximately 0.57 +/- 0.09 million cells per milligram of tissue total protein. Collagen type III composed an average of 34% to 40% of LP total collagen. Quantitative histology indicated that the superficial LP contained an average of 70% thin, 26% intermediate, and 4% thick collagen fibers. This is in contrast to the intermediate and deep LPs, each of which contained less than 25% thin and more than 50% thick collagen fibers. The angular deviations in collagen fiber orientation were relatively large and were similar in magnitude across all LP layers.
   Conclusions: The total cell density of the LP and associated epithelium was intermediate between that of hyaline cartilage and dermis. The ratio of collagen type III to total collagen in the LP was similar to that of highly elastic lung parenchyma and roughly twice that of the comparatively less-elastic dermis. The average thickness of collagen fibers increased markedly with increasing LP depth, and the relatively large angular deviations in fiber orientation appeared to correspond in part to the crimped nature of LP collagen fibers.
C1 [Munoz-Pinto, Dany; Hahn, Mariah S.] Texas A&M Univ, Dept Chem Engn, College Stn, TX 77843 USA.
   [Whittaker, Peter] Wayne State Univ, Cardiovasc Res Inst, Detroit, MI USA.
   [Whittaker, Peter] Wayne State Univ, Dept Emergency Med, Detroit, MI USA.
RP Hahn, MS (reprint author), Texas A&M Univ, Dept Chem Engn, 200 Jack E Brown Bldg,3122 TAMU, College Stn, TX 77843 USA.
RI Whittaker, Peter/F-1234-2011
OI Whittaker, Peter/0000-0002-5627-2166
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NR 32
TC 6
Z9 6
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD APR
PY 2009
VL 118
IS 4
BP 299
EP 306
PG 8
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 433TL
UT WOS:000265228600011
PM 19462852
ER

PT J
AU Ohashi, T
   Nishino, H
   Arai, Y
   Hyodo, M
   Takatsu, M
AF Ohashi, Toru
   Nishino, Hirohito
   Arai, Yoko
   Hyodo, Makoto
   Takatsu, Mitsuharu
TI Clinical Significance of the Summating Potential-Action Potential Ratio
   and the Action Potential Latency Difference for Condensation and
   Rarefaction Clicks in Meniere's Disease
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE action potential latency difference; condensation click; endolymphatic
   hydrops; endolymphatic pressure; rarefaction click; summating
   potential-action potential ratio
ID EXPERIMENTAL ENDOLYMPHATIC HYDROPS; TYMPANIC ELECTROCOCHLEOGRAPHY;
   GUINEA-PIG; INNER-EAR; ROUND-WINDOW; DIAGNOSIS; MODULATION; RESPONSES;
   MEMBRANE; PRESSURE
AB Objectives: This study was aimed to elucidate the diagnostic significance of the summating potential (SP)-action potential (AP) ratio and the AP latency difference between condensation and rarefaction clicks (AP con-rar difference) in Meniere's disease.
   Methods: The AP and SP were recorded transtympanically in 67 patients with definite Meniere's disease. The SP/AP ratio and the AP con-rar difference were assessed in terms of 1) their interrelationship, 2) their relationship to hearing level, and 3) the rate of occurrence of abnormal values according to the stages of Meniere's disease.
   Results: No correlation was found between the SP/AP ratio and the AP con-rar difference. Neither the SP/AP ratio in general nor the AP con-rar difference was correlated with the hearing level. However, enhanced values of the SP/AP ratio (0.35 or higher) were moderately correlated with the hearing level (r = 0.51), and their occurrence rate was 55.2%. All increased AP con-rar difference (0.13 ms or longer) was not correlated with the hearing level, and its occurrence rate was 50.2%; it appeared most frequently at stage 3 (p < 0.05).
   Conclusions: An enhanced SP/AP ratio might not always indicate the presence of endolymphatic hydrops associated with all increase in endolymphatic pressure. An increased AP con-rar difference might reflect the presence of a biased basilar membrane resulting from an increased endolymphatic pressure, and hence it is diagnostically essential to simultaneously evaluate the SP/AP ratio and the AP con-rar difference.
C1 [Ohashi, Toru; Nishino, Hirohito; Takatsu, Mitsuharu] Hadano Red Cross Hosp, Dept Otorhinolaryngol, Hadano, Kanagawa, Japan.
   [Arai, Yoko; Hyodo, Makoto] St Marianna Univ, Sch Med, Dept Otorhinolaryngol, Kawasaki, Kanagawa, Japan.
RP Ohashi, T (reprint author), Hadano Red Cross Hosp, Dept Otorhinolaryngol, 1-1 Tatenodai, Hadano, Kanagawa, Japan.
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NR 31
TC 7
Z9 7
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD APR
PY 2009
VL 118
IS 4
BP 307
EP 312
PG 6
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 433TL
UT WOS:000265228600012
PM 19462853
ER

PT J
AU de Heer, AMR
   Huygen, PLM
   Collin, RWJ
   Kremer, H
   Cremers, CWRJ
AF de Heer, Anne-Martine R.
   Huygen, Patrick L. M.
   Collin, Rob W. J.
   Kremer, Hannie
   Cremers, Cor W. R. J.
TI Mild and Variable Audiometric and Vestibular Features in a Third DFNA15
   Family With a Novel Mutation in POU4F3
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE DFNA15; genetic hearing impairment; POU4F3; presbycusis; transcription
   factor; vestibular impairment
ID NONSYNDROMIC HEARING-LOSS; TRANSCRIPTION FACTOR; COCH MUTATION;
   IMPAIRMENT; DOMAIN; GENE; LOCALIZATION; DFNA2/KCNQ4; PHENOTYPE; PROJECT
AB Objectives: Cochleovestibular characteristics were investigated in a Dutch DFNA15 family with a novel POU4F3 mutation, L223P.
   Methods: A 4-generation pedigree was constructed of the Dutch family with the novel L223P POU4F3 mutation. Pure tone audiometric data were collected and analyzed cross-sectionally in mutation carriers. Age-related typical audiograms were derived. Vestibular examination was performed in most of the mutation carriers. The results were compared to those obtained from previously identified 884del8 and L289F POU4F3 mutation carriers.
   Results: A novel Mutation (L223P) in POU4F3 segregated with hearing impairment in the present family. Audiometric analysis generally showed an early-adult to midlife onset of hearing impairment. High-frequency hearing impairment was observed most frequently. Age-related typical audiograms showed a down-sloping configuration at ages of more than 30 years, with the fastest rate of progression at the high frequencies. Vestibular function tests revealed hypofunction of the vestibular labyrinth in 2 mutation carriers (not statistically significant).
   Conclusions: The clinical features in the present family with a POU4F3 mutation were fairly similar to those in the 2 previously described DFNA15 families, but the level of hearing impairment was milder, and there was no substantial vestibular dysfunction.
C1 [de Heer, Anne-Martine R.; Huygen, Patrick L. M.; Collin, Rob W. J.; Kremer, Hannie; Cremers, Cor W. R. J.] Radboud Univ Nijmegen, Med Ctr, Dept Otorhinolaryngol, NL-6500 HB Nijmegen, Netherlands.
RP de Heer, AMR (reprint author), Radboud Univ Nijmegen, Med Ctr, Dept Otorhinolaryngol, POB 9101, NL-6500 HB Nijmegen, Netherlands.
RI Kremer, Hannie/F-5126-2010; Collin, Rob/N-3575-2014
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NR 35
TC 8
Z9 8
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD APR
PY 2009
VL 118
IS 4
BP 313
EP 320
PG 8
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 433TL
UT WOS:000265228600013
PM 19462854
ER

PT J
AU Ramadan, HH
AF Ramadan, Hassan H.
TI Safety and Feasibility of Balloon Sinuplasty for Treatment of Chronic
   Rhinosinusitis in Children
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT Annual Meeting of the Southern Section of the Triological-Society
CY JAN 10-11, 2008
CL Naples, FL
SP Triol Soc Southern Sect
DE balloon; child; rhinosinusitis
ID ENDOSCOPIC SINUS SURGERY; MANAGEMENT; ADENOIDECTOMY; DILATATION;
   DILATION; EFFICACY; THERAPY; ARTERY; OSTIA; CT
AB Objectives: Balloon sinuplasty is a new technique that was recently introduced for the treatment of chronic rhinosinusitis (CRS). The initial experience in adults has been promising. The technique allows for restoring ventilation to the sinuses with minimal risk and trauma to the tissues. I present our initial experience of its use for treatment of CRS in children.
   Methods: I performed a prospective study of 30 children in whom medical therapy failed and who were scheduled for surgery. They were offered treatment with balloon sinuplasty of selected sinuses. The data collected included age, computed tomography score, and comorbid conditions. The primary outcome was the intraoperative success of dilation of the sinuses and the rate of adverse events clue to the procedure.
   Results: The procedure was Successful in 51 of 56 sinuses (91%) in 30 children. Five sinuses, of which 4 were hypoplastic maxillary sinuses and I wits a frontal sinus, were not amenable to dilation. No complications or side effects were noted.
   Conclusions: The initial experience with balloon sinuplasty in children seems to be very encouraging. Because there is no bone or tissue removal, the procedure seems to be Suitable for use in children. A hypoplastic Sinus may not be amenable to balloon sinuplasty.
C1 [Ramadan, Hassan H.] W Virginia Univ, Dept Otolaryngol Head & Neck Surg, Morgantown, WV 26505 USA.
RP Ramadan, HH (reprint author), W Virginia Univ, Dept Otolaryngol, POB 9200, Morgantown, WV 26505 USA.
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NR 17
TC 20
Z9 21
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD MAR
PY 2009
VL 118
IS 3
BP 161
EP 165
PG 5
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 420HB
UT WOS:000264278600001
PM 19374145
ER

PT J
AU Chheda, NN
   Seybt, MW
   Schade, RR
   Postma, GN
AF Chheda, Neil N.
   Seybt, Melanie W.
   Schade, Robert R.
   Postma, Gregory N.
TI Normal Values for Pharyngeal pH Monitoring
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT 88th Annual Meeting of the American-Broncho-Esophagological-Association
CY MAY 01-02, 2008
CL Orlando, FL
SP Amer Broncho Esophagol Assoc
DE extraesophageal reflux; laryngopharyngeal reflux; pH monitor
ID LARYNGOPHARYNGEAL REFLUX; GASTROESOPHAGEAL-REFLUX; LARYNGEAL; DISEASE;
   RELIABILITY; ARTIFACTS; VALIDITY; ACID; GERD
AB Objectives: We performed a prospective study of asymptomatic adult volunteers to establish normative values of pharyngeal pH using a novel pH probe.
   Methods: The Dx-pH probe is a novel pH device capable of measuring liquid and aerosolized acid levels. Twenty asymptomatic patients (Reflux Symptom Index less than 10 and Reflux Finding Score less than 6) underwent simultaneous investigation with this probe placed in the oropharynx and a dual antimony probe placed in the hypopharynx and esophagus. The reflux parameters measured from the oropharyngeal probe included the percentage of time and the number of events in which the pH was less than 5.5, 5.0,4.5, and 4.0.
   Results: The upper limits of normal (95th percentile) for the number of events below pH of 5.5, 5.0,4.5, and 4.0 per 24-hour period were 16.6, 10.7, 7.4, and 0.2, respectively. The upper limits of normal (95th percentile) for an acid exposure time below pH of 5.5, 5.0. 4.5, and 4.0 per 24-hour period were 820 seconds, 385 seconds, 75 seconds, and 3 seconds, respectively.
   Conclusions: Normative pharyngeal pH values are presented. Further studies are required to determine clinical relevance.
C1 [Seybt, Melanie W.; Postma, Gregory N.] Med Coll Georgia, Dept Otolaryngol, Ctr Voice & Swallowing Disorders, Augusta, GA 30912 USA.
   [Chheda, Neil N.] Univ Florida, Dept Otolaryngol, Gainesville, FL USA.
   [Schade, Robert R.] Med Coll Georgia, Dept Med, Gastroenterol Sect, Augusta, GA 30912 USA.
RP Postma, GN (reprint author), Med Coll Georgia, Dept Otolaryngol, Ctr Voice & Swallowing Disorders, 1120 15th St, Augusta, GA 30912 USA.
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   Wo JM, 2002, DIGEST DIS SCI, V47, P2579, DOI 10.1023/A:1020584731503
NR 20
TC 17
Z9 18
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD MAR
PY 2009
VL 118
IS 3
BP 166
EP 171
PG 6
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 420HB
UT WOS:000264278600002
PM 19374146
ER

PT J
AU Yoshizaki, T
   Kondo, S
   Wakisaka, N
   Murono, S
   Kitagawa, N
   Tsuji, A
   Nakashima, M
   Sanada, J
   Matsui, O
AF Yoshizaki, Tomokazu
   Kondo, Satoru
   Wakisaka, Naohiro
   Murono, Shigeyuki
   Kitagawa, Noriko
   Tsuji, Akira
   Nakashima, Masashi
   Sanada, Jun-ichiro
   Matsui, Osamu
TI Concurrent Intra-arterial Chemotherapy and Radiotherapy for Advanced
   Laryngeal Cancer
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT Meeting of the Japanese-Head-and-Neck-Cancer-Society
CY JUN 11-13, 2008
CL Tokyo, JAPAN
SP Japanese Head & Neck Canc Soc
DE chemoradiotherapy; head and neck cancer; intra-arterial chemotherapy;
   laryngeal cancer; organ preservation
ID SQUAMOUS-CELL CARCINOMA; NECK-CANCER; ADVANCED HEAD; RADIATION-THERAPY;
   STAGE-III; CHEMORADIOTHERAPY; CHEMORADIATION; PRESERVATION; MANAGEMENT;
   CISPLATIN
AB Objectives: An intra-arterial chemoradiotherapy regimen (RADPLAT) provides remarkable local control for head and neck cancer. This study evaluates the efficacy of a reduced RADPLAT protocol in patients who are candidates for total laryngectomy.
   Methods: Forty-three patients with advanced laryngeal cancer were treated with 2 courses of intra-arterial cisplatin infusion (100 mg per body) during 40-Gy irradiation. The patients who showed a greatly diminished tumor received sequenc, tial irradiation. The patients with obvious residual disease received chemotherapy during the sequential irradiation. Poor responders, with less than 50% turnor reduction, underwent total laryngectomy.
   Results: Forty-two patients completed the protocol. All surviving patients were followed for at least 3 years. Thirty-four patients were alive (80% of the supraglottic cases and 87.5% of the glottic cases). Local control was achieved in 27 patients (67.5% of the I I glottic cases and 64.0% of the supraglottic cases). The glottic cohort showed better progression-free survival rates than did the supraglottic cohort (68.8% and 45.0%, respectively; p = 0.019). There were 2 cases of grade 3 neutropenia and 3 cases of grade 3 mucositis. No patients required tube feeding. One patient required tracheostomy 3 months after the completion of the treatment protocol.
   Conclusions: Concurrent chemoradiotherapy with I reduced dose of intra-arterial cisplatin is feasible for patients with advanced glottic cancer.
C1 [Yoshizaki, Tomokazu; Kondo, Satoru; Wakisaka, Naohiro; Murono, Shigeyuki; Kitagawa, Noriko; Tsuji, Akira; Nakashima, Masashi] Kanazawa Univ, Grad Sch Med Sci, Div Otolaryngol, Kanazawa, Ishikawa 9208641, Japan.
   [Sanada, Jun-ichiro; Matsui, Osamu] Kanazawa Univ, Grad Sch Med Sci, Div Radiol, Kanazawa, Ishikawa 9208641, Japan.
RP Yoshizaki, T (reprint author), Kanazawa Univ, Grad Sch Med Sci, Div Otolaryngol, 13-1 Takarmachi, Kanazawa, Ishikawa 9208641, Japan.
RI Sanada, Junichiro/C-4687-2015
OI Sanada, Junichiro/0000-0001-8416-6355
CR Adelstein DJ, 2000, CANCER, V88, P876, DOI 10.1002/(SICI)1097-0142(20000215)88:4<876::AID-CNCR19>3.0.CO;2-Y
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   Forastiere AA, 2003, NEW ENGL J MED, V349, P2091, DOI 10.1056/NEJMoa031317
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   Yoshizaki T, 2007, ANN OTO RHINOL LARYN, V116, P754
NR 19
TC 6
Z9 7
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD MAR
PY 2009
VL 118
IS 3
BP 172
EP 178
PG 7
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 420HB
UT WOS:000264278600003
PM 19374147
ER

PT J
AU Lahav, Y
   Rosenzweig, E
   Heyman, Z
   Doljansky, J
   Green, A
   Dagan, Y
AF Lahav, Yonatan
   Rosenzweig, Eyal
   Heyman, Zehava
   Doljansky, Julia
   Green, Amit
   Dagan, Yaron
TI Tongue Base Ultrasound: A Diagnostic Tool for Predicting Obstructive
   Sleep Apnea
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE obstruction; sleep apnea; tongue; ultrasound
ID RELIABILITY; REDUCTION; EXCISION; SPEECH
AB Objectives: We assessed the value of ail ultrasound (US) examination in the diagnostic workup of patients with sleep-related breathing disorders by correlating US measurements with known parameters for the presence and severity of obstructive Sleep apnea.
   Methods: Forty-one male patients who complained of snoring and/or daytime somnolence participated. The diagnostic protocol included history-taking, physical examination, polysomnography, and transcervical US examination of the tongue. The US results were compared with all of the other parameters.
   Results: The US imaging was reliable for demonstrating anatomic structures of the tongue base, discriminating between Muscle, mucosa, and blood vessels. The lingual arteries were clearly Visualized entering the tongue base at its lower lateral borders, There was a significant relationship between the severity of sleep-related breathing disorders (measured by polysomnograpily) and the width of the lower tongue base (measured as the distance between the lingual arteries). The distance between the lingual arteries also correlated with physical examination findings and patient complaints of daytime somnolence and the sensation of choking during the night.
   Conclusions: Tongue base width, measured by US, may influence the severity of obstructive sleep apnea. This is the first demonstration of the possible role of US examination, ail inexpensive, noninvasive, and non-irradiating office procedure, in the diagnostic workup for sleep-related breathing disorders. Key Words: obstruction, sleep apnea, tongue, ultrasound.
C1 [Lahav, Yonatan] Hebrew Univ Jerusalem, Kaplan Med Ctr, Dept Otolaryngol, IL-76100 Rehovot, Israel.
   [Rosenzweig, Eyal; Doljansky, Julia] Tel Aviv Univ, Chaim Sheba Med Ctr, Inst Fatigue & Sleep Med, Tel Hashomer, Israel.
   [Heyman, Zehava] Tel Aviv Univ, Chaim Sheba Med Ctr, Div Diagnost & Intervent Imaging, Ultrasound Unit, Tel Hashomer, Israel.
   [Dagan, Yaron] Tel Aviv Univ, Dept Med Educ, IL-69978 Tel Aviv, Israel.
   [Green, Amit; Dagan, Yaron] Assuta Med Ctr, Inst Sleep Med, Petah Tiqwa, Israel.
RP Lahav, Y (reprint author), Hebrew Univ Jerusalem, Kaplan Med Ctr, Dept Otolaryngol, POB 1, IL-76100 Rehovot, Israel.
CR Blumen MB, 2006, LARYNGOSCOPE, V116, P1887, DOI 10.1097/01.mlg.0000234935.25098.32
   Davidson TM, 2003, SLEEP MED, V4, P185, DOI 10.1016/S1389-9457(02)00237-X
   Faber Christian E, 2003, Sleep Breath, V7, P77, DOI 10.1007/s11325-003-0077-9
   Friedman M, 1999, LARYNGOSCOPE, V109, P1901, DOI 10.1097/00005537-199912000-00002
   Hiiemae KM, 2003, CRIT REV ORAL BIOL M, V14, P413
   JOHNS MW, 1992, SLEEP, V15, P376
   Lauretano AM, 1997, LARYNGOSCOPE, V107, P1057, DOI 10.1097/00005537-199708000-00010
   Lee JJ, 1997, OTOLARYNG HEAD NECK, V117, P326, DOI 10.1016/S0194-5998(97)70121-9
   Malhotra A, 2002, LANCET, V360, P237, DOI 10.1016/S0140-6736(02)09464-3
   Maturo SC, 2006, ANN OTO RHINOL LARYN, V115, P624
   Rama AN, 2002, CHEST, V122, P1139, DOI 10.1378/chest.122.4.1139
   Robinson S, 2003, CLIN OTOLARYNGOL, V28, P341, DOI 10.1046/j.1365-2273.2003.00719.x
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NR 14
TC 7
Z9 7
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD MAR
PY 2009
VL 118
IS 3
BP 179
EP 184
PG 6
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 420HB
UT WOS:000264278600004
PM 19374148
ER

PT J
AU Bhattacharyya, N
AF Bhattacharyya, Neil
TI Assessing the Additional Disease Burden of Polyps in Chronic
   Rhinosinusitis
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE chronic rhinosinusitis; diagnosis; medical costs; nasal polyposis
ID ENDOSCOPIC SINUS SURGERY; COMPUTED-TOMOGRAPHY; DIAGNOSIS; EPIDEMIOLOGY;
   OUTCOMES; SCORES
AB Objectives: This study was undertaken to determine the differential disease burden between chronic rhinosinusitis (CRS) cases with and without nasal polyposis (NP).
   Methods: A consecutive series of adult patients who met clinical and radiographic criteria for CRS was assessed with the Rhinosinusitis Symptom Inventory, nasal endoscopy, and computed tomography. Three clinical groups were examined: 1) CRS Without NP,21) CRS with primary NP (no prior Surgery), and 3) CRS with recurrent NP (prior Surgery). The groups were compared with respect to symptom presentation, medical resource utilization, and medication costs.
   Results: Two hundred eighty-six CRS cases without NP, 13 1 CRS cases with primary NP, and 45 CRS cases with recurrent NP were Studied; their mean Lund scores were 8.8, 13.2, and 16.3, respectively (p < 0.00 1). Statistically significant differences in severity for nasal (p = 0.002), facial (1) = 0.025), oropharyngeal (p = 0.0 17), and systemic symptoms (p = 0.042) between groups were noted, whereas total symptoms did not differ between groups (1) = 0.339). Medication use and physician visits were similar between groups (p = 0.335 and p = 0.95 1, respectively). The aggregate yearly medication costs were significantly greater for the recurrent polyp group ($866) than for either the non-polyp group ($570 p 0.0 13) or the primary polyp group ($565, p = 0.020).
   Conclusions: Patients with non-polyp CRS and those with primary polyp CRS present with different symptom phenotypes, but exhibit similar total symptom burdens and medical resource consumption. The presence of polyps does not necessarily confer a dramatic additional disease burden in CRS.
C1 [Bhattacharyya, Neil] Brigham & Womens Hosp, Div Otolaryngol, Boston, MA 02115 USA.
   [Bhattacharyya, Neil] Harvard Univ, Sch Med, Dept Otol & Laryngol, Boston, MA 02115 USA.
RP Bhattacharyya, N (reprint author), Div Otolaryngol, 45 Francis St, Boston, MA 02115 USA.
CR Anand VK, 2004, ANN OTO RHINOL LARYN, V113, P3
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   Bhattacharyya N, 2005, AM J RHINOL, V19, P175
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   Bhattacharyya N, 2003, AM J RHINOL, V17, P27
   Bhattacharyya N, 2003, LARYNGOSCOPE, V113, P125, DOI 10.1097/00005537-200301000-00023
   Bradley DT, 2005, LARYNGOSCOPE, V115, P466, DOI 10.1097/01.mlg.0000157840.55659.62
   Bugten V, 2008, RHINOLOGY, V46, P40
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   Gliklich RE, 1998, OTOLARYNG HEAD NECK, V118, P344, DOI 10.1016/S0194-5998(98)70313-4
   Hamilos Daniel L, 2007, Clin Allergy Immunol, V20, P1
   Kountakis SE, 2004, LARYNGOSCOPE, V114, P1895, DOI 10.1097/01.mlg.0000147917.43615.e0
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   Rosenfeld RM, 2007, OTOLARYNG HEAD NECK, V137, pS1, DOI 10.1016/j.otohns.2007.06.726
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NR 21
TC 9
Z9 9
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD MAR
PY 2009
VL 118
IS 3
BP 185
EP 189
PG 5
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 420HB
UT WOS:000264278600005
PM 19374149
ER

PT J
AU Butler, SG
   Stuart, A
   Markley, L
   Rees, C
AF Butler, Susan G.
   Stuart, Andrew
   Markley, Lisa
   Rees, Catherine
TI Penetration and Aspiration in Healthy Older Adults as Assessed During
   Endoscopic Evaluation of Swallowing
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT 16th Annual Meeting of the Dysphagia-Research-Society
CY MAR 06, 2008
CL Charleston, SC
SP Dysphagia Res Soc
DE age; dysphagia; endoscopy; FEES; flexible endoscopic evaluation of
   swallowing; gender; swallowing
ID COMMUNITY-ACQUIRED PNEUMONIA; SCALE; VIDEOFLUOROSCOPY; POPULATION
AB Objectives: A previous article from Our group presented data on normal swallowing as assessed during simultaneous manometry and flexible endoscopic evaluation of swallowing (FEES). Because penetration and aspiration events were identified in healthy adults, the question arose, could the presence of the manometric catheter confound normal FEES findings? Thus, a follow-up study was designed to address the effects of catheter condition on healthy older adults as assessed during FEES.
   Methods: Twenty older adults (mean, 78.9 years of age) participated. The participants each contributed 28 swallows, affording a study total of 560 swallows for analyses.
   Results: The older adults demonstrated penetration on 82 (15%) and aspiration on 18 (3%) of 545 swallows. The numbers of participants who had penetration and aspiration during the study protocol were 75% and 30%, respectively. The older adults demonstrated both penetration and aspiration events irrespective of the presence of a catheter; whether they were drinking milk, water, or barium: whether the bolus was 5 or 10 mL; and whether they took the bolus via syringe or self-administered the bolus With a Cup. However, significantly more aspiration was found on thin liquids than on puree or solids.
   Conclusions: Endoscopic data on normal swallowing physiology were generated. These may serve its an accurate benchmark for clinicians and researchers in the interpretation of dysphagia.
C1 [Butler, Susan G.; Rees, Catherine] Wake Forest Univ, Sch Med, Dept Otolaryngol, Ctr Voice & Swallowing Disorders, Winston Salem, NC 27157 USA.
   [Stuart, Andrew] E Carolina Univ, Coll Allied Hlth Sci, Dept Commun Sci & Disorders, Greenville, NC 27858 USA.
   [Markley, Lisa] Durham Vet Affairs Med Ctr, Dept Speech Language Pathol & Audiol, Durham, NC USA.
RP Butler, SG (reprint author), Wake Forest Univ, Sch Med, Dept Otolaryngol, Ctr Voice & Swallowing Disorders, Med Ctr Blvd, Winston Salem, NC 27157 USA.
CR Almirall J, 2000, EUR RESPIR J, V15, P757, DOI 10.1034/j.1399-3003.2000.15d21.x
   Butler SG, 2009, ANN OTO RHINOL LARYN, V118, P99
   Colodny N, 2002, DYSPHAGIA, V17, P308, DOI 10.1007/s00455-002-0073-0
   Daggett A, 2006, DYSPHAGIA, V21, P270, DOI 10.1007/s00455-006-9051-6
   Hind JA, 2001, ARCH PHYS MED REHAB, V82, P1661, DOI 10.1053/apmr.2001.28006
   JOKINEN C, 1993, AM J EPIDEMIOL, V137, P977
   Kaplan V, 2002, AM J RESP CRIT CARE, V165, P766, DOI 10.1164/rccm.2103038
   Kelly AM, 2007, LARYNGOSCOPE, V117, P1723, DOI 10.1097/MLG.0b013e318123ee6a
   KOIVULA I, 1994, AM J MED, V96, P313, DOI 10.1016/0002-9343(94)90060-4
   LANGMORE SE, 1991, ANN OTO RHINOL LARYN, V100, P678
   Leder SB, 1998, DYSPHAGIA, V13, P19, DOI 10.1007/PL00009544
   LOGEMANN JA, 1983, EVALUATION TREATMENT, P249
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   Suiter DM, 2007, OTOLARYNG HEAD NECK, V137, P956, DOI 10.1016/j.otohns.2007.09.004
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   Wu CH, 1997, LARYNGOSCOPE, V107, P396
NR 19
TC 27
Z9 27
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD MAR
PY 2009
VL 118
IS 3
BP 190
EP 198
PG 9
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 420HB
UT WOS:000264278600006
PM 19374150
ER

PT J
AU Pennings, RJE
   Cremers, CWRJ
AF Pennings, Ronald J. E.
   Cremers, Cor W. R. J.
TI Postauricular Approach Atticotomy: A Modified Closed Technique With
   Reconstruction of the Scutum With Cymbal Cartilage
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE anterior epitympanum; atticotomy; cholesteatoma; closed technique;
   combined approach tympanoplasty; epitympanotomy
ID CHOLESTEATOMA
AB Objectives: We studied the results of postauricular approach atticotomy in patients with cholesteatotma of the anterior epitympanum.
   Methods: Twenty-six patients were selected for removal of cholesteatoma of the anterior epitympanum by postauricular approach atticotomy, a closed transcanal procedure that is used to expose and remove cholesteatoma. After removal of cholesteatoma, reconstruction Of the scutum is performed with cymbal cartilage.
   Results: Postauricular approach atticotomy can be performed as part of a canal Wall Lip procedure in selected cases in which cholesteatoma invades the anterior epitympanum. Especially if the ossicular chain is intact and if there is an anteriorly curved medial outer canal wall, this technique is useful in avoiding an open technique. A second-look procedure is recommended because of a relatively high percentage of recurrent and residual disease.
   Conclusions: Postauricular approach atticotomy with reconstruction of the Scutum is a Useful technique to remove cholesteatoma from the anterior epitympanum.
C1 [Pennings, Ronald J. E.; Cremers, Cor W. R. J.] Radboud Univ Nijmegen, Med Ctr, Dept Otorhinolaryngol, NL-6500 HB Nijmegen, Netherlands.
RP Pennings, RJE (reprint author), Radboud Univ Nijmegen, Med Ctr, Dept Otorhinolaryngol, POB 9101, NL-6500 HB Nijmegen, Netherlands.
RI Pennings, Ronald/J-6651-2012
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   DONALD PJ, 1979, LARYNGOSCOPE, V89, P195
   Duckert LG, 2002, OTOL NEUROTOL, V23, P8, DOI 10.1097/00129492-200201000-00003
   East DM, 1998, CLIN OTOLARYNGOL, V23, P248
   Jansen C, 1968, J Laryngol Otol, V82, P779, DOI 10.1017/S0022215100069462
   Jansen C, 1972, Otolaryngol Clin North Am, V5, P79
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NR 10
TC 5
Z9 7
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD MAR
PY 2009
VL 118
IS 3
BP 199
EP 204
PG 6
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 420HB
UT WOS:000264278600007
PM 19374151
ER

PT J
AU Capaccio, P
   Cuccarini, V
   Ottaviani, F
   Fracchiolla, NS
   Bossi, A
   Pignataro, L
AF Capaccio, Pasquale
   Cuccarini, Valeria
   Ottaviani, Francesco
   Fracchiolla, Nicola Stefano
   Bossi, Anna
   Pignataro, Lorenzo
TI Prothrombotic Gene Mutations in Patients With Sudden Sensorineural
   Hearing Loss and Cardiovascular Thrombotic Disease
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE cardiovascular thrombotic disease; MTHFR gene mutation; platelet gene
   mutation; prothrombin gene mutation; sudden sensorineural hearing loss;
   V Leiden gene
ID FACTOR-V-LEIDEN; METHYLENETETRAHYDROFOLATE-REDUCTASE GENE; VENOUS
   THROMBOEMBOLISM; RISK-FACTORS; DNA HYPOMETHYLATION; G20210A MUTATIONS;
   ISCHEMIC-STROKE; MTHFR C677T; POLYMORPHISM; HYPERHOMOCYSTEINEMIA
AB Objectives: Impaired cochlear perfusion seems to be an important event in sudden sensorineural heading loss. Prothrombotic gene mutations have been related to vascular disorders and sudden hearing loss. We assessed the prothrombotic risk in 10 patients with sudden sensorineural hearing loss who had previously experienced cardiovascular events to support its vascular pathogenesis.
   Methods: Ten patients underwent hematologic tests (MTHER C677T/A1298C, prothrombin G20210A, platelet were compared with those of 100 previously investigated patients With Sudden hearing loss alone and those of 200 healthy controls. DNA was isolated from peripheral blood leukocytes, and the gene mutations were investigated by polymerase chain reaction and a LightCycler DNA analyzer.
   Results: Two patient had 2 mutant alleles, 6 had 3, and 2 had 4. The mean homocysteine, cholesterol, and fibrinogen levels were above the Upper limit of normal; the mean folate levels were slightly above the lower limit of normal. Multiple mutations were more frequent in the patient group than in the previously analyzed patients and healthy controls.
   Conclusions: The association between inherited and acquired prothrombotic factors ill Patients With sudden sensorineural hearing loss and thrombotic diseases in other sitcs that a multifactorial mechanism may underlic microvascular cochlear impairment. Hematologic investigation, including MTHFR, prothrornbin, platelet,and V Leiden genotyping, may help to detect patients at potential risk of recurrent hearing loss and Multiple microvascular diseases. and could be usefully performed in otherwise idiopathic Sudden sensorineural hearing loss.
C1 [Capaccio, Pasquale; Cuccarini, Valeria; Pignataro, Lorenzo] Univ Milan, Fdn IRCCS Policlin Mangiagalli & Regina Elena, Dept Otorhinolaryngol & Ophthalmol Sci, I-20122 Milan, Italy.
   [Ottaviani, Francesco] Univ Milan, Fdn IRCCS Policlin Mangiagalli & Regina Elena, Dept Clin Sci, I-20122 Milan, Italy.
   [Fracchiolla, Nicola Stefano] Univ Milan, Fdn IRCCS Policlin Mangiagalli & Regina Elena, Operat Unit Hematol, I-20122 Milan, Italy.
   [Bossi, Anna] Univ Milan, Fdn IRCCS Policlin Mangiagalli & Regina Elena, Inst Med Stat, I-20122 Milan, Italy.
   [Ottaviani, Francesco] L Sacco Hosp Vialba, Dept Clin Sci, Div Otolaryngol, Milan, Italy.
RP Capaccio, P (reprint author), Univ Milan, Fdn IRCCS Policlin Mangiagalli & Regina Elena, Dept Otorhinolaryngol & Ophthalmol Sci, Via F Sforza 35, I-20122 Milan, Italy.
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NR 30
TC 20
Z9 22
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD MAR
PY 2009
VL 118
IS 3
BP 205
EP 210
PG 6
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 420HB
UT WOS:000264278600008
PM 19374152
ER

PT J
AU Lee, TJ
   Huang, SF
   Chang, PH
AF Lee, Ta-Jen
   Huang, Shiang-Fu
   Chang, Po-Hung
TI Characteristics of Isolated Sphenoid Sinus Aspergilloma: Report of
   Twelve Cases and Literature Review
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE aspergilloma; endoscopic sinus surgery; isolated sphenoid sinusitis
ID FUNGUS BALLS; DISEASE; DIAGNOSIS; CT; LESIONS; MANAGEMENT; GRANULOMA;
   SECONDARY; SURGERY; TUMOR
AB Objectives: Isolated sphenoid sinus aspergilloma (ISSA) is a form of fungal sinus infection that is distinct from allergic fungal sinusitis, invasive fungal disease, and Aspergillus granulomas. In this Study, we identify the characteristics of patients with ISSA to achieve timelier intervention for this easily neglected disease.
   Methods: In a retrospective study of patients with ISSA in our institution (1995 to 2006), 12 were identified.
   Results: Sixty-seven percent of our patients were more than 50 years of age, and a female preponderance was noted. Headache and postnasal drip were the two most common symptoms, and the samples from 78% of our patients with postnasal drip were blood-tinged. Computed tomographic scanning provided a sensitivity of 64%, whereas endoscopic examination failed to identify abnomalities in any patients.
   Conclusions: Four characteristics were identified in the diagnosis of ISSA: female; usually above 50 years of age, with Postnasal drip (especially blood-tinged); and headache (particularly periorbital or
C1 [Lee, Ta-Jen; Huang, Shiang-Fu; Chang, Po-Hung] Chang Gung Univ, Chang Gung Mem Hosp, Dept Otolaryngol, Tao Yuan 333, Taiwan.
RP Huang, SF (reprint author), Chang Gung Univ, Chang Gung Mem Hosp, Dept Otolaryngol, 5 Fu-Shin St, Tao Yuan 333, Taiwan.
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NR 54
TC 8
Z9 9
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD MAR
PY 2009
VL 118
IS 3
BP 211
EP 217
PG 7
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 420HB
UT WOS:000264278600009
PM 19374153
ER

PT J
AU Branski, RC
   Barbieri, SS
   Weksler, BB
   Saltman, B
   Krishna, P
   Kraus, DH
   Broadbelt, NV
   Chen, J
   Poppas, DP
   Felsen, D
AF Branski, Ryan C.
   Barbieri, Silvia S.
   Weksler, Babette B.
   Saltman, Benjamin
   Krishna, Priya
   Kraus, Dennis H.
   Broadbelt, Nallni V.
   Chen, Jie
   Poppas, Dix P.
   Felsen, Diane
TI Effects of Transforming Growth Factor-beta 1 on Human Vocal Fold
   Fibroblasts
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE fibrosis; transforming growth factor; vocal fold; voice
ID GROWTH-FACTOR-BETA; UNILATERAL URETERAL OBSTRUCTION;
   EXTRACELLULAR-MATRIX; GENE-EXPRESSION; SENESCENT EXPRESSION; TISSUE
   INHIBITORS; HEPATIC-FIBROSIS; RABBIT MODEL; CELL-LINES; T-ANTIGEN
AB Objectives: We studied the effect of transforming growth factor (TGF)-beta on immortalized human vocal fold fibroblasts.
   Methods: Normal human vocal fold fibroblasts were subjected to sequential lentiviral transduction with genes for human telomerase (hTERT) and SV40 large T antigen in order to produce an "immortalized" cell line of normal phenotype. After confirmation of vocal fold fibroblast transfection, these cells, referred to as HVOX, were treated with various concentrations of exogenous TGF-beta 1 and assayed for collagen secretion, migration, and proliferation. In addition, components of the TGF-beta signaling pathway were examined in this cell line.
   Results: TGF-beta stimulated collagen secretion and migration without altering proliferation of HVOX. HVOX constitutive ly expressed type I and II TGF-beta receptors, as well as messenger RNA for the Smad signaling proteins and for all TGF-beta isoforms. Exogenous TGF-beta 1 induced temporally dependent alterations in Smad2 and Smad3 gene expression. TGF-beta increased Smad7 expression at both 4 and 24 hours. Prolonged exposure to TGF-P decreased TGF-beta 1 gene expression.
   Conclusions: Insight into the underlying pathophysiology of vocal fold fibrosis is likely to yield improved therapeutic strategies to mitigate vocal fold scarring. Our data suggest that TGF-beta signaling may be both paracrine and autocrine in this vocal fold fibroblast cell line, and we therefore propose that TGF-beta may be a reasonable target for therapies to prevent and/or treat vocal fold fibrosis, given its putative role in both acute and chronic vocal fold injury, as well as its effects on vocal fold fibroblasts.
C1 [Branski, Ryan C.; Saltman, Benjamin; Kraus, Dennis H.] Mem Sloan Kettering Canc Ctr, Dept Head & Neck Surg, New York, NY 10021 USA.
   [Branski, Ryan C.; Kraus, Dennis H.] Weill Cornell Med Coll, Dept Otorhinolaryngol, New York, NY USA.
   [Branski, Ryan C.; Saltman, Benjamin; Broadbelt, Nallni V.; Chen, Jie; Poppas, Dix P.; Felsen, Diane] Weill Cornell Med Coll, Inst Pediat Urol, Dept Urol, New York, NY USA.
   [Barbieri, Silvia S.; Weksler, Babette B.] Weill Cornell Med Coll, Div Hematol & Med Oncol, New York, NY USA.
   [Krishna, Priya] Univ Pittsburgh, Med Ctr, Dept Otolaryngol, Voice Ctr, Pittsburgh, PA USA.
   [Barbieri, Silvia S.] Univ Milan, Dept Pharmacol Sci, Milan, Italy.
RP Branski, RC (reprint author), Mem Sloan Kettering Canc Ctr, Dept Head & Neck Surg, Box 104,1275 York Ave, New York, NY 10021 USA.
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NR 42
TC 17
Z9 18
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD MAR
PY 2009
VL 118
IS 3
BP 218
EP 226
PG 9
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 420HB
UT WOS:000264278600010
PM 19374154
ER

PT J
AU Gemma, M
   Piccioni, LO
   Gioia, L
   Beretta, L
   Bussi, M
AF Gemma, Marco
   Piccioni, Lucia Oriella
   Gioia, Luigi
   Beretta, Luigi
   Bussi, Mario
TI Ropivacaine Peritonsillar Infiltration for Analgesia After
   Adenotonsillectomy in Children: A Randomized, Double-Blind,
   Placebo-Controlled Study
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE adenotonsillectomy; anesthesia; postoperative pain; ropivacaine
ID POST-TONSILLECTOMY PAIN; POSTOPERATIVE PAIN; BUPIVACAINE
AB Objectives: Our randomized, double-blind, placebo-controlled study evaluates the possible benefit of peritonsillar infiltration with 0,75% ropivacaine hydrochloride on the pain level after adenotonsillectomy in 3- to 7-year-old children.
   Methods: We randomly administered intraoperative peritonsillar infiltration with 0.2 mL/kg ropivacaine 0.75% (group R) or 0.2 mL/kg saline 0.9% (group F) to sixty 3- to 7-year-old children (ASA I or 2) who were undergoing adenotonsillectomy. Postoperative pain was assessed 6 and 24 hours after surgery by a 6-face Faces Pain Scale that allowed quantification of pain on a 100-mm horizontal line (0 = no pain). The number of rectal doses of acetaminophen-codeine required during the first postoperative day was recorded.
   Results: The pain scores did not differ between the groups, either 6 or 24 hours after surgery (group F, 43 26, versus group R, 29 23, and group F, 24 23, versus group R, 30 28, respectively). Acetaminophen-codeine doses were similarly required in the two groups.
   Conclusions: Peritonsillar infiltration with 0.75% ropivacaine does not provide any major postoperative analgesic effect in 3- to 7-year-old children after adenotonsillectomy. A possible clinically minor analgesia 6 hours after surge is suggested.
C1 [Gemma, Marco; Gioia, Luigi; Beretta, Luigi] Sci Inst S Raffaele Hosp, Anesthesia & Intens Care Unit Head & Neck Surg, I-20132 Milan, Italy.
   [Piccioni, Lucia Oriella; Bussi, Mario] Sci Inst S Raffaele Hosp, Dept Otolaryngol Surg, I-20132 Milan, Italy.
RP Gemma, M (reprint author), Sci Inst S Raffaele Hosp, Anesthesia & Intens Care Unit Head & Neck Surg, Via Olgettina 60, I-20132 Milan, Italy.
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NR 20
TC 11
Z9 11
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD MAR
PY 2009
VL 118
IS 3
BP 227
EP 231
PG 5
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 420HB
UT WOS:000264278600011
PM 19374155
ER

PT J
AU Oren, L
   Khosla, S
   Murugappan, S
   King, R
   Gutmark, E
AF Oren, Liran
   Khosla, Sid
   Murugappan, Shanmugam
   King, Richard
   Gutmark, Ephraim
TI Role of Subglottal Shape in Turbulence Reduction
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE phonation; phonosurgery; subglottic stenosis; vocal cord paralysis;
   voice
ID TEX MEDIALIZATION THYROPLASTY; CANINE LARYNX MODEL; VOICE QUALITY;
   PHONATION; FLOW; BREATHY; RESECTION; VELOCITY; STENOSIS; FEMALE
AB Objectives: In previous work, we found that airflow at the superior edge of the vocal folds, in the excised canine larynx, can be laminar even when the tracheal airflow is predominantly turbulent. Turbulent flow directly above the folds may lead to ail irregular or "rouah" voice. Thus, it is important to determine the mechanism of turbulence reduction. From fluid mechanics, it is known that a smoothly converging duct will reduce turbulence. In this study, we tested the hypothesis that the majority of the turbulence reduction is due to the smooth converging shape of the subglottis.
   Methods: In 3 excised canine larynges, hot-wire anemometry was used to measure the turbulence intensity (TI) below the cricoid cartilage and 2 to 3 mm above the superior edge of the vocal folds. Laminar flow was seen when the TI was approximately less than 2%. For our measurements, flow into the subglottis had an average TI of more than 20% (high turbulence) in the shear layer and a TI of more than 15% in the center of the jet. The larynges were tested under steady conditions (folds not phonating) with the vocal processes approximated.
   Results: For the center of the jet, there is moderate turbulence below the cricoid cartilage and laminar flow 2 to 3 min above the folds. For the shear layer, there is very high turbulence below the cricoid cartilage and low turbulence 2 to 3 mm above the folds.
   Conclusions: The smooth converging shape of the subglottis can produce a significant reduction in turbulence. These C C findings may have important voice implications for operations that may change the subglottal shape (such as vocal fold medialization or airway reconstruction).
C1 [Khosla, Sid; Murugappan, Shanmugam; King, Richard; Gutmark, Ephraim] Univ Cincinnati, Med Ctr, Dept Otolaryngol Head & Neck Surg, Cincinnati, OH 45267 USA.
   [Oren, Liran; Gutmark, Ephraim] Univ Cincinnati, Dept Aerosp Engn & Engn Mech, Cincinnati, OH 45221 USA.
RP Khosla, S (reprint author), Univ Cincinnati, Med Ctr, Dept Otolaryngol Head & Neck Surg, 231 Albert B Sabin Way, Cincinnati, OH 45267 USA.
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NR 32
TC 9
Z9 9
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD MAR
PY 2009
VL 118
IS 3
BP 232
EP 240
PG 9
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 420HB
UT WOS:000264278600012
PM 19374156
ER

PT J
AU Deutsch, ES
   Christenson, T
   Curry, J
   Hossain, J
   Zur, K
   Jacobs, I
AF Deutsch, Ellen S.
   Christenson, Thomas
   Curry, Joseph
   Hossain, Jobayer
   Zur, Karen
   Jacobs, Ian
TI Multimodality Education for Airway Endoscopy Skill Development
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT 88th Annual Meeting of the American-Broncho-Esophagological-Association
CY MAY 01-02, 2008
CL Orlando, FL
SP Amer Broncho Esophagol Assoc
DE education; endoscopy; simulation
ID MEDICAL-EDUCATION; SIMULATION
AB Objectives: Airway endoscopy is a difficult skill to master. A unique practicum was designed to help otolaryngology resin dents develop endoscopy skills. The learning modalities included lectures, an animal laboratory, high-fidelity manikins, virtual bronchoscopy simulation, and standardized patients. This study compares the relative subjective value of these learning modalities for skill development and realism.
   Methods: Participants used a Likert scale (1 = disagree to 5 = agree) and open responses to anonymously rate the efficacy of 5 learning modalities for teaching airway management, endoscopy skills, and clinical leadership and for providing a realistic experience.
   Results: The results in 2007 were uniformly positive, with mean scores for every category and modality greater than 4 for developing cognitive, psychomotor, and affective skills; managing normal and abnormal conditions; preventing and managing, complications; improving endoscopy skills; understanding team process; and experiencing overall and manual "feel" realism. In 2008, the participants were encouraged to more critically evaluate the course. The ratings demonstrated statistically significant differences between the mean scores for 4 of the 9 evaluation categories in 2007 and all 9 categories in 2008.
   Conclusions: Specific learning modalities (eg, lecture, animal laboratory, high-fidelity manikin, virtual bronchoscopy, standardized patient) were perceived to have different values for teaching airway management, developing encloscopy skills, teaching clinical leadership, and providing a realistic experience. We propose that these learning modalities can be used in a complementary manner.
C1 [Deutsch, Ellen S.] Alfred I duPont Hosp Children, Div Pediat Otolaryngol, Dept Surg, Wilmington, DE 19899 USA.
   [Hossain, Jobayer] Alfred I duPont Hosp Children, Dept Biomed Sci, Wilmington, DE 19899 USA.
   [Christenson, Thomas; Curry, Joseph] Univ Penn, Childrens Hosp Philadelphia, Sch Med, Dept Otolaryngol Head & Neck Surg,Jefferson Med C, Philadelphia, PA 19104 USA.
   [Zur, Karen; Jacobs, Ian] Univ Penn, Childrens Hosp Philadelphia, Sch Med, Dept Surg, Philadelphia, PA 19104 USA.
RP Deutsch, ES (reprint author), Alfred I duPont Hosp Children, Div Pediat Otolaryngol, Dept Surg, Wilmington, DE 19899 USA.
CR Gaba DM, 2004, QUAL SAF HLTH CAR S1, V13, pi2, DOI DOI 10.1135/QSHC.2004.009878
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   Reznick RK, 2006, NEW ENGL J MED, V355, P2664
   Rudman DT, 1998, LARYNGOSCOPE, V108, P1643, DOI 10.1097/00005537-199811000-00010
   Ziv A, 2003, ACAD MED, V78, P783, DOI 10.1097/00001888-200308000-00006
NR 6
TC 11
Z9 11
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD FEB
PY 2009
VL 118
IS 2
BP 81
EP 86
PG 6
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 412PA
UT WOS:000263735500001
PM 19326756
ER

PT J
AU Rosenberg, TL
   Schweinfurth, JM
AF Rosenberg, Tara L.
   Schweinfurth, John M.
TI Cell Density of the Lamina Propria of Neonatal Vocal Folds
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT 88th Annual Meeting of the American-Broncho-Esophagological-Association
CY MAY 01-02, 2008
CL Orlando, FL
SP Amer Broncho Esophagol Assoc
DE cell density; lamina propria; neonate; vocal fold
AB Objectives: We undertook 1) to measure the cell density within the lamina propria of the neonatal vocal folds and 2) to examine changes in cell density in the lamina propria with increasing gestational age of the neonatal vocal folds.
   Methods: Intact neonatal larynges were obtained from fresh cadaveric specimens. Hematoxylin and eosin-stained slides were used to visualize the laryngeal structures, and photomicrographs of the vocal folds were taken at 100x magnification. The cell density of the lamina propria was calculated by counting the cells within each of five 100-mu m(2) regions within the study area, and the totals were then averaged for each area.
   Results: A total of 62 sections from 14 larynges with gestational ages of 19 to 36 weeks were examined. Histologic analysis revealed a uniform appearance of the vocal fold without apparent layers. The cell density of the lamina propria was 30 or more cells per 100 mu m(2) for 51.2% of larynges with less than 27 weeks of gestation. However, only 14.3% of the larynges with 27 or more weeks of gestation had an average cell density of 30 or more cells per region (p < 0.005).
   Conclusions: As described by previous studies, the lamina propria of the neonatal vocal folds is a hypercellular monolayer. The process of vocal fold maturation appears to occur earlier than previously thought, with decreasing cell density in the lamina propria by 27 weeks' gestation.
C1 [Rosenberg, Tara L.; Schweinfurth, John M.] Univ Mississippi, Med Ctr, Dept Otolaryngol & Communicat Sci, Jackson, MS 39216 USA.
RP Rosenberg, TL (reprint author), Univ Mississippi, Med Ctr, Dept Otolaryngol, 2500 N State St, Jackson, MS 39216 USA.
CR FAWCETT DW, 1986, TXB HISTOLOGY, P136
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NR 14
TC 2
Z9 2
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD FEB
PY 2009
VL 118
IS 2
BP 87
EP 90
PG 4
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 412PA
UT WOS:000263735500002
PM 19326757
ER

PT J
AU Sharp, DB
   Castellanos, PF
AF Sharp, Dawn B.
   Castellanos, Paul F.
TI Clinical Outcomes of Bedside Percutaneous Dilatational Tracheostomy With
   Suspension Laryngoscopy for Airway Control
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT 88th Annual Meeting of the American-Broncho-Esophagological-Association
CY MAY 01-02, 2008
CL Orlando, FL
SP Amer Broncho Esophagol Assoc
DE airway; laryngoscopy; percutaneous dilatational tracheostomy
ID CRITICALLY-ILL PATIENTS; SURGICAL TRACHEOSTOMY; TRACHEOTOMY; SAFETY;
   COST
AB Objectives: We sought to describe outcomes of a new technique blending suspension laryngoscopy (SL) with percutaneous dilatational tracheostomy (PDT), addressing concerns of airway control and risks of dire complications.
   Methods: A retrospective review of 67 cases included "all comers," in that if the patient could undergo any type of tracheostomy, SL-PDT was offered, and it was performed in all but 1 patient. Patient demographics, intubation time, time from consultation to procedure, and perioperative complications were reviewed.
   Results: Sixty-six patients underwent SL-PDT; 54 procedures were performed bedside in the intensive care unit, and 12 in the operating room. Use of the operating room was due to lack of intensivist availability or possible need for an emergent surgical airway. Early in the series, 1 patient required open tracheostomy because of unfavorable anatomy. Two major complications occurred: 1 perioperative airway obstruction and 1 severe bradycardic event. The 2 patients were resuscitated without significant sequelae. Three minor complications occurred: 2 cases of endotracheal bleeding and 1 transient bradycardic event.
   Conclusions: Bedside SL-PDT is relatively safe and effective, and offers advantages over traditional PDT and open tracheostomy. This novel technique may encourage a concerted multidisciplinary effort, including otolaryngologists, to continue to improve bedside airway management in critically ill patients.
C1 [Castellanos, Paul F.] UAB, Aerodigest Ctr, Dept Surg, Div Otolaryngol Head & Neck Surg, Birmingham, AL 35294 USA.
   [Castellanos, Paul F.] UAB, Voice & Aerodigest Ctr, Kirklin Clin, Birmingham, AL 35294 USA.
RP Castellanos, PF (reprint author), UAB, Aerodigest Ctr, Dept Surg, Div Otolaryngol Head & Neck Surg, BDB Suite 563,1808 7th Ave S, Birmingham, AL 35294 USA.
CR Ahmed Nasim, 2007, Surg Infect (Larchmt), V8, P343, DOI 10.1089/sur.2006.065
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   Blanch M, 2004, PROF ENG, V17, P21
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   Byhahn C, 2000, ANESTH ANALG, V91, P882, DOI 10.1097/00000539-200010000-00021
   Castellanos P, 2005, J VOICE, V19, P470, DOI 10.1016/j.jvoice.2004.06.001
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NR 20
TC 4
Z9 5
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD FEB
PY 2009
VL 118
IS 2
BP 91
EP 98
PG 8
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 412PA
UT WOS:000263735500003
PM 19326758
ER

PT J
AU Butler, SG
   Stuart, A
   Kemp, S
AF Butler, Susan G.
   Stuart, Andrew
   Kemp, Shannon
TI Flexible Endoscopic Evaluation of Swallowing in Healthy Young and Older
   Adults
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT 15th Annual Meeting of the Dysphagia-Research-Society
CY MAR 08-10, 2007
CL Vancouver, CANADA
SP Dysphagia Res Soc
DE age; dysphagia; endoscopy; FEES; flexible endoscopic evaluation of
   swallowing; gender; swallowing
ID PENETRATION-ASPIRATION SCALE; NASOGASTRIC TUBES; VIDEOFLUOROSCOPY;
   RELIABILITY; COORDINATION; INTERJUDGE; PHYSIOLOGY; DYSPHAGIA; AGES
AB Objectives: Scant data exist on normal swallowing as assessed endoscopically. A lack of understanding for the range of normal swallowing may lead to inaccurate diagnoses and overly aggressive management of patients with dysphalgia. Accordingly, the purpose of this study was to determine the effects of age (ie, young versus older), gender, bolus Volume (ie, 5 versus 10 mL), and bolus condition (ie, water versus milk) on Penetration-Aspiration Scale scores, bolus dwell little, pharyngeal closure duration, and residue in healthy adults.
   Methods: Twenty-three young adults (mean, 30.0 years of age) and 21 older adults (mean, 75.0 years of age) participated .Measurements were acquired during manoendoscopic swallowing assessments. The participants contributed 8 swallows, affording a Study total of 352 swallows for analysis.
   Results: The older adults demonstrated penetration on 19 swallows and aspiration on 11 swallows out of 168 swallows. There was a significant difference in the proportion of Penetration-Aspiration Scale scores across age and gender groups. Longer bolus dwell times were seen in older adults and with milk boluses, whereas residue severity was less in young adults and with water boluses.
   Conclusions: Endoscopic data on normal swallowing physiology were generated. These data may serve as an accurate benchmark for clinicians and researchers in the interpretation of dysphagia.
C1 [Butler, Susan G.; Kemp, Shannon] Wake Forest Univ, Sch Med, Ctr Voice & Swallowing Disorders, Dept Otolaryngol, Winston Salem, NC 27157 USA.
   [Stuart, Andrew] E Carolina Univ, Dept Commun Sci & Disorders, Coll Allied Hlth Sci, Greenville, NC USA.
RP Butler, SG (reprint author), Wake Forest Univ, Sch Med, Ctr Voice & Swallowing Disorders, Dept Otolaryngol, Med Ctr Blvd, Winston Salem, NC 27157 USA.
CR Belafsky PC, 2002, J VOICE, V16, P274, DOI 10.1016/S0892-1997(02)00097-8
   Colodny N, 2002, DYSPHAGIA, V17, P308, DOI 10.1007/s00455-002-0073-0
   Daggett A, 2006, DYSPHAGIA, V21, P270, DOI 10.1007/s00455-006-9051-6
   Dozier TS, 2006, LARYNGOSCOPE, V116, P1489, DOI 10.1097/01.mlg.0000227724.61801.b4
   Dua KS, 1997, GASTROENTEROLOGY, V112, P73, DOI 10.1016/S0016-5085(97)70221-X
   Hind JA, 2001, ARCH PHYS MED REHAB, V82, P1661, DOI 10.1053/apmr.2001.28006
   Hiss SG, 2003, LARYNGOSCOPE, V113, P1386, DOI 10.1097/00005537-200308000-00023
   Huggins PS, 1999, DYSPHAGIA, V14, P157, DOI 10.1007/PL00009598
   Johnson PE, 2003, ANN OTO RHINOL LARYN, V112, P14
   Kelly AM, 2006, CLIN OTOLARYNGOL, V31, P425, DOI 10.1111/j.1749-4486.2006.01292.x
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   Langmore S, 2001, ENDOSCOPIC EVALUATIO
   Langmore Susan E, 2003, Curr Opin Otolaryngol Head Neck Surg, V11, P485, DOI 10.1097/00020840-200312000-00014
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   Suiter DM, 2007, OTOLARYNG HEAD NECK, V137, P956, DOI 10.1016/j.otohns.2007.09.004
   Tabaee A, 2006, LARYNGOSCOPE, V116, P821, DOI 10.1097/01.mlg.0000214670.40604.45
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NR 31
TC 27
Z9 27
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD FEB
PY 2009
VL 118
IS 2
BP 99
EP 106
PG 8
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 412PA
UT WOS:000263735500004
PM 19326759
ER

PT J
AU Catalano, PJ
   Payne, SC
AF Catalano, Peter J.
   Payne, Spencer C.
TI Balloon Dilation of the Frontal Recess in Patients With Chronic Frontal
   Sinusitis and Advanced Sinus Disease: An Initial Report
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE balloon dilation technology; minimally invasive technique
ID FOLLOW-UP; SAFETY; FEASIBILITY; OSTIA
AB Objectives: Balloon dilation of the sinus ostia and transition spaces is a relatively new tool in the management of chronic rhinosinusitis. Although Studies of its safety and application have been reported, its efficacy in specific indications has yet to be clearly defined. The purpose of this study was to evaluate the use of balloon dilation of the frontal recess for the treatment of chronic frontal sinusitis in patients with advanced sinus disease.
   Methods: This was a prospective study of 20 patients who presented with chronic frontal sinusitis that had failed medical therapy and required operative intervention. Balloon dilation of the frontal recess was performed to improve drainage and ventilation of the frontal sinus. Preoperative and postoperative Computed tomography scans were compared for change in the radiologic stage of disease based both on the Lund-Mackay staging system and on the Lund grade (extent of mucosal thickening).
   Results: Twenty patients met the inclusion criteria during the study period and were followed for several months after operation. All patients underwent a frontal sinus procedure with balloon dilation either alone or in concert with other minimally invasive techniques. A total of 29 sinuses were available for analysis. No significant complications resulted from the procedure. Pretreatment and posttreatment Lund-Mackay scores showed significant improvement in patients with certain subsets of chronic rhinosinusitis.
   Conclusions: Balloon dilation of the frontal recess is a relatively safe intervention that can be used in the treatment of chronic frontal sinusitis, even in patients with advanced disease.
C1 [Catalano, Peter J.] Lahey Clin Fdn, Dept Otolaryngol Head & Neck Surg, Burlington, MA 01805 USA.
   [Payne, Spencer C.] Univ Virginia, Dept Otolaryngol Head & Neck Surg, Charlottesville, VA USA.
   [Catalano, Peter J.] Acclarent Inc, Menlo Pk, CA USA.
RP Catalano, PJ (reprint author), Lahey Clin Fdn, Dept Otolaryngol Head & Neck Surg, 41 Mall Rd, Burlington, MA 01805 USA.
CR Benninger MS, 2003, OTOLARYNG HEAD NECK, V129, pS1, DOI 10.1016/S0194-5998(03)01397-4
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   Bolger WE, 2007, OTOLARYNG HEAD NECK, V137, P10, DOI 10.1016/j.otohns.2007.02.006
   Brown CL, 2006, ANN OTO RHINOL LARYN, V115, P293
   Burt C, 2004, VITAL HLTH STAT, V13, P1
   Catalano P J, 2006, OP TECH OTOLARYNGOL, V17, P189, DOI 10.1016/j.otot.2006.06.001
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NR 15
TC 21
Z9 23
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD FEB
PY 2009
VL 118
IS 2
BP 107
EP 112
PG 6
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 412PA
UT WOS:000263735500005
PM 19326760
ER

PT J
AU Tomaz, A
   Gananca, MM
   Gananca, CF
   Gananca, FF
   Caovilla, HH
   Harker, L
AF Tomaz, Andreza
   Gananca, Mauricio Malavasi
   Gananca, Cristina Freitas
   Gananca, Fernando Freitas
   Caovilla, Heloisa Helena
   Harker, Lee
TI Benign Paroxysmal Positional Vertigo: Concomitant Involvement of
   Different Semicircular Canals
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT 5th Triological Congress of Otorhinolaryngology
CY JUN 06-09, 2007
CL Brasilia, BRAZIL
DE inner ear; semicircular canal; vertigo
ID NYSTAGMUS; BPPV; FEATURES
AB Objectives: We evaluated the simultaneous ipsilateral or contralateral involvement of the posterior and lateral, anterior and lateral, or posterior and anterior semicircular canals in patients with benign paroxysmal positional vertigo (BPPV).
   Methods: The files of 2,345 patients with BPPV were analyzed.
   Results: Single-canal BPPV occurred in 2,3 10 cases (98.5%) - unilaterally in 2,058 (89.1%) and bilaterally in 252 (10.9%). Multiple-canal BPPV occurred in 35 cases (1.5%). Of these 35 cases, there was simultaneous involvement of the posterior and lateral canals on the same side (23) or on opposite sides (9) in 32 cases (91.4%). Simultaneous involvement of the anterior canal on one side and the posterior canal on the opposite side occurred in 2 cases (5.7%), and that of the anterior canal on one side and the lateral canal on the opposite side occurred in 1 case (2.9%). All cases represented canalithiasis.
   Conclusions: Multiple-canal BPPV was rare, and usually involved canals on the same side; simultaneous involvement of the posterior and lateral canals was Much more common than involvement of the anterior and posterior canals or the anterior and lateral canals. Trauma increased the risk for multiple-canal BPPV, but not the risk for bilateral single-canal BPPV. Cupulolithiasis was not a factor in multiple-canal BPPV.
C1 [Tomaz, Andreza; Gananca, Cristina Freitas] Univ Fed Sao Paulo, Dept Human Commun Disorders, Paulista Sch Med, Sao Paulo, Brazil.
   [Gananca, Mauricio Malavasi] Univ Fed Sao Paulo, Dept Otorhinolaryngol, Paulista Sch Med, Sao Paulo, Brazil.
   [Gananca, Fernando Freitas; Caovilla, Heloisa Helena] Univ Fed Sao Paulo, Dept Neurootol, Paulista Sch Med, Sao Paulo, Brazil.
   [Gananca, Mauricio Malavasi; Gananca, Fernando Freitas] Univ Bandeirante Sao Paulo, Postgrad Course Vestibular Rehabil & Social Inclu, Sao Paulo, Brazil.
   [Harker, Lee] Univ Fed Sao Paulo, Dept Otorhinolaryngol, Paulista Sch Med, Sao Paulo, Brazil.
RP Tomaz, A (reprint author), Rua Heitor Penteado 1739,Apt 102, BR-05437001 Sao Paulo, Brazil.
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NR 30
TC 9
Z9 10
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD FEB
PY 2009
VL 118
IS 2
BP 113
EP 117
PG 5
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 412PA
UT WOS:000263735500006
PM 19326761
ER

PT J
AU Mallur, PS
   Harirchian, S
   Lalwani, AK
AF Mallur, Pavan S.
   Harirchian, Sanaz
   Lalwani, Anil K.
TI Preoperative and Postoperative Intracranial Complications of Acute
   Mastoiditis
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE acute mastoiditis; epidural abscess; intracranial complication; sigmoid
   sinus thrombosis
ID LATERAL SINUS THROMBOSIS; ACUTE OTITIS-MEDIA; CHILDREN; ERA
AB Objectives: We determined the clinical characteristics and treatment outcomes of an unusual cluster of intracranial complications seen in acute mastoiditis (AM).
   Methods: We performed a retrospective review of pediatric patients treated for AM in a tertiary care hospital from March 2006 to March 2007.
   Results: Eleven children, 6 months to 10 years of age (mean age, 3.8 years), were treated for AM confirmed by computed tomography, which identified asymptomatic intracranial complications in 8 of the 11 patients: these were sigmoid sinus thrombosis (4 patients), epidural abscess (4), perisigmoid abscess or bony erosion (2), and tegmen mastoideum dehiscence (1). All patients required operative intervention with tympanomastoidectomy, although only 2 patients required neurosurgical intervention, consisting of evacuation of epidural abscess and sigmoid sinus thrombosis, respectively. Cultures yielded routine organisms and 1 multidrug-resistant strain of Streptococcus pneumoniae. One patient developed reaccumulation of the subperiosteal abscess that required revision mastoidectomy, and another patient developed postoperative sigmoid sinus thrombosis.
   Conclusions: Although uncommon, intracranial complications of AM may present without clinical signs or symptoms. Computed tomography of the temporal bone with contrast is essential for identifying asymptomatic complications. Mastoidectomy remains the mainstay of surgical treatment. Neurosurgical intervention and anticoagulation may be avoided with protracted postoperative intravenous antibiotics. Postoperative vigilance is crucial, as complications may evolve despite aggressive therapy.
C1 [Mallur, Pavan S.; Lalwani, Anil K.] NYU, Dept Otolaryngol, Med Ctr, New York, NY 10016 USA.
   [Harirchian, Sanaz] NYU, Sch Med, Dept Otolaryngol, New York, NY 10016 USA.
RP Lalwani, AK (reprint author), NYU, Dept Otolaryngol, Med Ctr, 550 1St Ave,NBV 5E5, New York, NY 10016 USA.
CR Agarwal A, 2003, ANN OTO RHINOL LARYN, V112, P191
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NR 20
TC 8
Z9 8
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD FEB
PY 2009
VL 118
IS 2
BP 118
EP 123
PG 6
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 412PA
UT WOS:000263735500007
PM 19326762
ER

PT J
AU Rieves, AL
   Hoffman, MR
   Jiang, JJ
AF Rieves, Adam L.
   Hoffman, Matthew R.
   Jiang, Jack J.
TI Indirect Estimation of Laryngeal Resistance Via Airflow Redirection
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE aerodynamic power; airflow redirection; laryngeal resistance; subglottal
   pressure
ID ESTIMATING SUBGLOTTAL PRESSURE; PHONATION THRESHOLD PRESSURE;
   AERODYNAMICS; INTERRUPTION; EFFICIENCY; NODULES
AB Objectives: Our aim was to estimate aerodynamic parameters of laryngeal resistance (RL) and aerodynamic power indirectly from a subglottal pressure (Ps) data trace obtained with the airflow redirection system.
   Methods: During airflow interruption, the airflow redirection tank fills capacitively with pressure until it reaches the Subject's Ps. Therefore, a time constant, T, can be extracted from the data trace and used to calculate RL. The validity of applying this method to the estimation of RL was demonstrated with a computer model. Estimations were made for values of 10, 20, 30 40, and 50 cm H(2)O per liter per second (L/s). Twenty subjects performed 10 trials on the experimental system designed to measure Ps. The values of RL and aerodynamic power were then calculated.
   Results: The computer model simulation yielded a maximum measurement error of 3.00% and a mean error of 1.78%. In human subject testing, the mean +/- SD laryngeal resistance was 22.61 +/- 8.65 cm H(2)O per L/s, the mean Ps was 6.91 +/- 1.94 cm H(2)O, and the mean aerodynamic power was 0.247 +/- 0.170 kPa x (L/s).
   Conclusions: The proposed method of data analysis enables a clinician to estimate RL and aerodynamic power from a single experimental trial designed to measure Ps. This technique provides the clinician with an aerodynamic function report that can be used to analyze patient health and treatment efficacy.
C1 [Rieves, Adam L.; Hoffman, Matthew R.; Jiang, Jack J.] Univ Wisconsin, Dept Surg, Div Otolaryngol Head & Neck Surg, Sch Med & Publ Hlth, Madison, WI USA.
RP Jiang, JJ (reprint author), 5745 Med Sci Ctr,1300 Univ Ave, Madison, WI 53706 USA.
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NR 23
TC 1
Z9 2
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD FEB
PY 2009
VL 118
IS 2
BP 124
EP 130
PG 7
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 412PA
UT WOS:000263735500008
PM 19326763
ER

PT J
AU Yamashita, M
   Bless, DM
   Welham, NV
AF Yamashita, Masaru
   Bless, Diane M.
   Welham, Nathan V.
TI Surgical Method to Create Vocal Fold Injuries in Mice
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT 88th Annual Meeting of the American-Broncho-Esophagological-Association
CY MAY 01-02, 2008
CL Orlando, FL
SP Amer Broncho Esophagol Assoc
DE histology; immunohistochemistry; mouse endoscopic surgery; scarring;
   vocal fold injury
ID MURINE LARYNX; MODEL; HISTOLOGY; GENOME; RATS
AB Objectives: The goal of this study was to develop a surgical method for the creation of vocal fold injuries in mice, its a precursor to the use of genetically engineered mouse models in the study of vocal fold wound healing and scar formation.
   Methods: Seven FVB strain mice were used in this study. A laryngoscope and 3 micro-instruments were designed and fabricated to facilitate endoscopic vocal fold visualization and the creation of vocal fold surgical injuries. The larynges were harvested 1 and 7 days after surgery, and the vocal fold injury sites were evaluated by routine hematoxylin and eosin staining. Additional immunohistochemical analysis of collagen type I and elastin distribution in the lamina propria was performed for an uninjured control larynx.
   Results: Endoscopic visualization and vocal fold stripping resulting in thyroarytenoid muscle exposure were successful in all animals. Histologic and immunohistochemical analyses revealed it simple lamina propria structure with relatively even collagen type I and elastin distribution in the control vocal fold, obliteration of vocal fold mucosa 1 day after surgery, and complete reepithelialization by 7 clays.
   Conclusions: These results demonstrate the feasibility of creating reproducible vocal fold injuries via an endoscopic approach in mice. The observation that the mouse lamina propria may have a relatively simple histologic structure indicates that additional characterization should be performed and caution used in translating findings between this and other model systems.
C1 [Yamashita, Masaru; Bless, Diane M.; Welham, Nathan V.] Univ Wisconsin, Sch Med & Publ Hlth, Dept Surg, Div Otolaryngol Head & Neck Surg, Madison, WI USA.
RP Welham, NV (reprint author), K4-723 CSC,600 Highland Ave, Madison, WI 53792 USA.
RI Yamashita, Masaru/B-2411-2009
CR Abdelkafy WM, 2007, ANN OTO RHINOL LARYN, V116, P618
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NR 19
TC 5
Z9 5
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD FEB
PY 2009
VL 118
IS 2
BP 131
EP 138
PG 8
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 412PA
UT WOS:000263735500009
PM 19326764
ER

PT J
AU Pires, VL
   Mankarious, LA
AF Pires, Valerie L.
   Mankarious, Leila A.
TI Inflammatory Cytokine Response to Injury in the Aging Rabbit Subglottis
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE epidermal growth factor; fibroblast growth factor 2; inflammatory
   cytokine; platelet-derived growth factor; rabbit; subglottic mucosal
   wound healing; subglottic stenosis; tracheal mucosal wound healing;
   transforming growth factor beta 1; vascular endothelial growth factor;
   wound healing model
ID GROWTH-FACTORS; MANAGEMENT; ANGIOGENESIS; STENOSIS; MUCOSA
C1 [Pires, Valerie L.; Mankarious, Leila A.] Harvard Univ, Massachusetts Eye & Ear Infirm, Sch Med, Dept Otolaryngol, Boston, MA 02114 USA.
RP Pires, VL (reprint author), Harvard Univ, Massachusetts Eye & Ear Infirm, Sch Med, Dept Otolaryngol, 243 Charles St, Boston, MA 02114 USA.
CR BENNETT NT, 1993, AM J SURG, V166, P74, DOI 10.1016/S0002-9610(05)80589-6
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   Ferrara N, 1997, ENDOCR REV, V18, P4, DOI 10.1210/er.18.1.4
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   Gould S J, 1988, J Laryngol Otol Suppl, V17, P3
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   Svendsen MN, 2002, SCAND J GASTROENTERO, V37, P373, DOI 10.1080/003655202317315971
NR 11
TC 0
Z9 0
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD FEB
PY 2009
VL 118
IS 2
BP 139
EP 147
PG 9
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 412PA
UT WOS:000263735500010
PM 19326765
ER

PT J
AU Sasaki, CT
   Hundal, JS
   Wadie, M
   Woo, JS
   Rosenblatt, W
AF Sasaki, Clarence T.
   Hundal, Jagdeep S.
   Wadie, Mikhail
   Woo, Jeong-Soo
   Rosenblatt, William
TI Modulating Effects of Hypoxia and Hypercarbia on Glottic Closing Force
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT 88th Annual Meeting of the American-Broncho-Esophagological-Association
CY MAY 01-02, 2008
CL Orlando, FL
SP Amer Broncho Esophagol Assoc
DE aspiration; glottic closure reflex; hypercarbia; hypoxia
ID CLOSURE REFLEX; MECHANISMS; HUMANS
AB Objectives: Aspiration has been identified as one of the independent risk factors for development of respiratory tract infections, the incidence of which varies from 10% to 65% in patients in intensive care units. The primary defense mechanism for protection of the lower airway is the glottic closure reflex (GCR), elicited by stimulation of the internal branch of the superior laryngeal nerve. This reflex, once considered highly stable, is now considered vulnerable to a growing number of clinical factors. This study was designed to explore the biomechanical effects of hypoxia and hypercarbia, common occurrences among critically ill patients, on the GCR.
   Methods: Five adult male Yorkshire pigs were used in the study. Both internal superior laryngeal nerves were simultaneously stimulated with bipolar platinum-iridium electrodes. The glottic closing force (GCF) was then measured by placing a pressure transducer between the adducting vocal folds under 3 different protocols: protocol 1 (control), protocol 2 (hypoxia: partial pressure of arterial oxygen 1 Pao2] levels of 90, 70, and 50 mm Hg), and protocol 3 (hypercarbia: partial pressure of arterial carbon dioxide [Paco2] levels of 60 and 70 mm Hg). Six readings were recorded under each experimental paradigm, and Student's t-test was applied to calculate the statistical significance against the control.
   Results: Hypoxia reduced the GCF to 75%, 40%, and 29% of control for P 102 levels of 90, 70, and 50 mm Hg, respectively, and hypercarbia reduced the GCF to 40% and 27% of control for Paco2 levels of 60 and 70 rum Fig, respectively.
   Conclusions: This is the first study that highlights the biomechanical impact of hypoxia and hypercarbia on the GCR, providing a unified explanation for the increased incidence of life-threatening aspiration in critically ill patients with such alterations.
C1 [Sasaki, Clarence T.] Yale Sch Med, Otolaryngol Sect, Dept Surg, New Haven, CT 06520 USA.
   [Rosenblatt, William] Yale Sch Med, Dept Anesthesia, New Haven, CT 06520 USA.
RP Sasaki, CT (reprint author), Yale Sch Med, Otolaryngol Sect, Dept Surg, 333 Cedar St,POB 208041, New Haven, CT 06520 USA.
CR Cardoso Teresa C, 2007, BMC Pulm Med, V7, P12, DOI 10.1186/1471-2466-7-12
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   IKARI T, 1980, ANN OTO RHINOL LARYN, V89, P220
   INSALACO G, 1990, J APPL PHYSIOL, V69, P268
   Medda BK, 2003, AM J PHYSIOL-GASTR L, V284, pG933, DOI 10.1152/ajpgi.00395.2002
   Sasaki CT, 2003, ANN OTO RHINOL LARYN, V112, P293
   UTZSCHNEIDER DA, 1991, BRAIN RES, V551, P136, DOI 10.1016/0006-8993(91)90924-K
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NR 8
TC 1
Z9 1
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD FEB
PY 2009
VL 118
IS 2
BP 148
EP 153
PG 6
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 412PA
UT WOS:000263735500011
PM 19326766
ER

PT J
AU Witt, RE
   Regner, MF
   Tao, C
   Rieves, AL
   Zhuang, PY
   Jiang, JJ
AF Witt, Rachel E.
   Regner, Michael F.
   Tao, Chao
   Rieves, Adam L.
   Zhuang, Peiyun
   Jiang, Jack J.
TI Effect of Dehydration on Phonation Threshold Flow in Excised Canine
   Larynges
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE excised larynx; dehydration; phonation; phonation threshold flow
ID HYDRATION; PRESSURE
AB Objectives: The minimum airflow necessary to initiate stable vocal fold vibration - phonation threshold flow (PTF) - may increase as exposure to dry air increases. A critical period of dehydration may exist after which phonation can no longer be initiated.
   Methods: We collected PTF data for 11 excised canine larynges mounted on a bench apparatus. Trials consisted of cycles of 10 seconds of phonation followed by 3 seconds of rest. During the experimental trials, subglottal flow of comparatively dry air was increased until phonation was initiated, and phonation was sustained for the remainder of the 10-second period. The subglottal flow was then decreased until phonation ceased. No saline solution was applied during the dehydration trials. During the control trials, subglottal airflow was humidified and saline solution was applied frequently to the vocal folds.
   Results: The PTF increased as exposure to dry air increased during the experimental trials (p = 0.010); this relationship was not statistically significant in control trials. A point existed after which phonation could not be initiated.
   Conclusions: Knowledge of the effect of exposure to dry air on PTF could be useful in the clinical assessment and prevention of dehydration. Further exploration of this relationship in vivo could be used to evaluate the effectiveness of current hydration therapies and provide theoretical support for the development of new ones.
C1 [Witt, Rachel E.; Regner, Michael F.; Tao, Chao; Rieves, Adam L.; Zhuang, Peiyun; Jiang, Jack J.] Univ Wisconsin, Dept Surg, Div Otolaryngol Head & Neck Surg, Sch Med & Publ Hlth, Madison, WI USA.
RP Jiang, JJ (reprint author), 5745 Med Sci Ctr,1300 Univ Ave, Madison, WI 53706 USA.
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NR 16
TC 14
Z9 15
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD FEB
PY 2009
VL 118
IS 2
BP 154
EP 159
PG 6
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 412PA
UT WOS:000263735500012
PM 19326767
ER

PT J
AU Golub, JS
   Johns, MM
   Lim, JH
   DelGaudio, JM
   Klein, AM
AF Golub, Justin S.
   Johns, Michael M., III
   Lim, Jae H.
   DelGaudio, John M.
   Klein, Adam M.
TI Comparison of an Oropharyngeal pH Probe and a Standard Dual pH Probe for
   Diagnosis of Laryngopharyngeal Reflux
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE acid reflux; extraesophageal reflux; gastroesophageal reflux disease;
   laryngopharyngeal reflux; pH probe; supraesophageal reflux
ID LARYNGEAL; GASTROESOPHAGEAL; RELIABILITY; DISORDERS; IMPEDANCE;
   SYMPTOMS; VALIDITY; VOICE; SIGNS
AB Objectives: We compared the ability of an oropharyngeal (OP) aerosol-detecting pH probe and a standard dual pH probe in measuring laryngopharyngeal reflux (LPR).
   Methods: Fifteen Subjects with LPR symptoms had 24-hour simultaneous placement of the OP probe and a standard dual pH probe. Acid exposure was defined as a 10% pH decrease below baseline for the OP probe or it pH of less than 4 at the Lipper esophageal sphincter (UES) probe of the dual pH probe.
   Results: The mean duration of acid exposure was 650 seconds (SD, 619) or 0.75% of the total time for the OP probe and 438 seconds (SD, 511) or 0.51% of the total time for the UES probe. When we excluded meals and sleep, the mean duration of acid exposure was 271 seconds (SD, 356) or 0.31% of the total time for the OP probe and 27 1 seconds (SD, 359) or 0.31% of the total time for the UES probe. The correlation coefficient (R) between the two probes for measurement of the duration of acid exposure was 0.50 (p < 0.05). When we excluded meals and the supine position, the R was notably higher, at 0.95 (p < 0.0001).
   Conclusions: The OP probe reliably documented LPR events when meals and sleep were eliminated and was better tolerated than the standard dual probe.
C1 [Golub, Justin S.; Lim, Jae H.] Univ Washington, Dept Otolarynol Head & Neck Surg, Washington, DC USA.
   [Johns, Michael M., III; DelGaudio, John M.; Klein, Adam M.] Emory Univ, Sch Med, Emory Voice Ctr, Dept Otolarynol Head & Neck Surg, Atlanta, GA 30308 USA.
RP Klein, AM (reprint author), Emory Univ, Sch Med, Emory Voice Ctr, Dept Otolarynol Head & Neck Surg, 550 Peachtree St,9th Floor,Suite 4400, Atlanta, GA 30308 USA.
FU AstraZeneca
FX Front the Department of Otolaryngology-Head and Neck Surgery, University
   of Washington, Seattle. Washington (Golub, Lim), and the Department of
   Otolaryngology-Head and Neck Surgery, Emory Voice Center, Emory
   University School of Medicine, Atlanta, Georgia (Johns, DelGaudio,
   Klein). This study was funded via an investigator-initiated grant from
   AstraZeneca. AstraZeneca has no affiliation with the pH probe device
   that was studied. The pH probes were donated by Restech and Medtronic
   Xomed.
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   WIENER GJ, J VOICE IN PRESS
NR 16
TC 13
Z9 13
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD JAN
PY 2009
VL 118
IS 1
BP 1
EP 5
PG 5
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 399HT
UT WOS:000262791700001
PM 19244956
ER

PT J
AU Shaw, GY
   Pierce, E
AF Shaw, Gary Y.
   Pierce, Elizabeth
TI Malpractice Litigation Involving Iatrogenic Surgical Vocal Fold
   Paralysis: A Closed-Claims Review With Recommendations for Prevention
   and Management
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE closed claim; malpractice; Surgical complication; vocal fold paralysis
ID ANTERIOR CERVICAL-SPINE; LARYNGEAL NERVE INJURY; MEDICAL MALPRACTICE;
   INFORMED CONSENT; CORD PARALYSIS; MEDICOLEGAL ANALYSIS; ADVERSE EVENTS;
   THYROID-GLAND; SURGERY; CANCER
AB Objectives: We describe the nature of malpractice claims filed involving surgical iatrogenic vocal fold paralysis, review surgical literature for recommendations for prevention of this complication, and suggest management of this complication.
   Methods: Data collection was made regarding any closed claims that involved vocal fold paralysis. The results were then analyzed and categorized. The PubMed literature regarding this complication was reviewed, and recommendations on prevention were compiled. Finally, suggestions regarding management based on the current literature and the senior author's 17-year experience in his laryngeal practice are offered.
   Results: From 1986 to 2007, 112 closed claims involving vocal fold paralysis were reported by the 16 largest malpractice insurers. More than US $10 million ($18 million adjusted for inflation [AJI]) has been paid thus far. The average indemnity was $285,000 ($513,000 AJI). The surgical physician defendants were from multiple specialties, including general surgery (31%), cardiothoracic surgery (12%), neurosurgery (12%), otolaryngology (10%). and orthopedic surgery (5%). The most common procedures were thyroid and parathyroid surgery (32%). cervical disc procedures (16%), thoracic procedures (12%), endarterectomy (9%), and open neck biopsy (6%). The most common claims cited were improper performance (61%), failure to recognize a complication (36%), and consent issues (19%).
   Conclusions: Vocal fold paralysis is a complication of many different Surgical procedures across multiple specialty lines. Closed-claims analysis can offer a unique glimpse on what went wrong and why patients sue. Modification of techniques and incorporation of new technology may significantly reduce this complication. Preoperative written information on potential complications, and early referral to and management by laryngeal specialists, we believe, may significantly reduce malpractice litigation.
C1 [Shaw, Gary Y.; Pierce, Elizabeth] Kansas City Univ Med & Biomed Sci, Dept Surg, Kansas City, MO USA.
   [Shaw, Gary Y.] Med Res Ctr, Voice & Swallowing Care Ctr, Kansas City, MO USA.
RP Shaw, GY (reprint author), Lees Summit ENT, 296 NE Tudor Rd, Lees Summit, MO 64086 USA.
FU Voice and Swallowing Care Foundation of Kansas
FX From the Department of Surgery, Kansas City University of Medicine and
   Biomedical Science (both authors), and the Voice and Swallowing Care
   Center, Research Medical Center (Shaw). Kansas City. Missouri. This
   research was supported by a grant from the Voice and Swallowing Care
   Foundation of Kansas. a not-for-profit corporation. This study was
   reviewed by the Human Subjects Study Committee of Research Medical
   Center, who determined that formal approval was not necessary.
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NR 42
TC 12
Z9 15
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD JAN
PY 2009
VL 118
IS 1
BP 6
EP 12
PG 7
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 399HT
UT WOS:000262791700002
PM 19244957
ER

PT J
AU Danielides, V
   Katotomichelakis, M
   Balatsouras, D
   Riga, M
   Tripsianis, G
   Simopoulou, M
   Nikolettos, N
AF Danielides, Vassilios
   Katotomichelakis, Michael
   Balatsouras, Dimitrios
   Riga, Maria
   Tripsianis, Gregory
   Simopoulou, Maria
   Nikolettos, Nikolaos
TI Improvement of Olfaction After Endoscopic Sinus Surgery in Smokers and
   Nonsmokers
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE endoscopic sinus surgery; nasal polyposis; olfactory function; smoking;
   Sniffin' Sticks
ID SMELL IDENTIFICATION TEST; OF-PENNSYLVANIA SMELL; CHRONIC
   RHINOSINUSITIS; ENDONASAL SURGERY; NASAL POLYPOSIS; SMOKING; UNIVERSITY;
   DYSFUNCTION; PREVALENCE; OUTCOMES
AB Objectives: The aim of this prospective study was to examine the short-term benefit of endoscopic sinus surgery (ESS) oil the olfactory function of patients operated on for nasal polyposis. We also studied the predictive value of smoking for the recovery of the olfactory function in these patients.
   Methods: We studied 116 patients with nasal polyposis who underwent ESS. Olfactory testing was performed with the Sniffin' Sticks test before operation and 1, 3, and 6 months after operation.
   Results: All patients achieved a statistically significant stepwise increment of all of the indices of olfactory function over time. The composite threshold-discrimination-identification score was lower in smokers than in nonsmokers in all test-in-sessions, but none of these differences reached statistical significance. After adjustment for preoperative olfactory measures and all other potential confounders, the effect of smoking oil the 6-month postoperative measurement was not significant. However, we did find a statistically significant adverse effect of the quantity of smoking on the olfactory threshold scores.
   Conclusions: Both smokers and nonsmokers achieve a highly significant improvement on their olfactory function from ESS. Although smoking is not a major predictive factor for the short-term outcome of the olfactory function after ESS, a greater quantity of smoking may have an effect on the 6-month postoperative odor thresholds.
C1 [Danielides, Vassilios; Katotomichelakis, Michael; Riga, Maria] Democritus Univ Thrace, Dept Otolaryngol, Sch Med, Alexandroupolis, Greece.
   [Tripsianis, Gregory] Democritus Univ Thrace, Dept Med Stat, Sch Med, Alexandroupolis, Greece.
   [Simopoulou, Maria; Nikolettos, Nikolaos] Democritus Univ Thrace, Dept Physiol, Sch Med, Alexandroupolis, Greece.
   [Balatsouras, Dimitrios] Tzan Gen Hosp Piracus, Dept Otolaryngol, Piraeus, Balatsouras, Greece.
RP Balatsouras, D (reprint author), 23 Acha Str, Athens 15343, Greece.
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NR 37
TC 10
Z9 10
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD JAN
PY 2009
VL 118
IS 1
BP 13
EP 20
PG 8
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 399HT
UT WOS:000262791700003
PM 19244958
ER

PT J
AU Cheung, EJ
   Wagner, H
   Botti, JJ
   Fedok, F
   Goldenberg, D
AF Cheung, Esther J.
   Wagner, Henry, Jr.
   Botti, John J.
   Fedok, Fred
   Goldenberg, David
TI Advanced Oral Tongue Cancer in a 22-Year-Old Pregnant Woman
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE chemotherapy; fetus; head and neck cancer; oral tongue cancer;
   pregnancy; radiotherapy
ID SQUAMOUS-CELL CARCINOMA; RADIATION-THERAPY; NECK-CANCER; HEAD;
   CHEMOTHERAPY; RADIOTHERAPY; PACLITAXEL; MANAGEMENT; TUMORS
AB Objectives: Oral squamous cell carcinoma generally occurs in older men and is associated mostly with tobacco and alcohol as the primary risk factors. The incidence of oral squamous Cell carcinoma in younger patients has increased. We report a case of a young woman, 25 weeks pregnant, who presented with stage IV carcinoma of the oral tongue.
   Methods: The following is a case presentation and literature review.
   Results: The patient presented with T4 N3 MO oral tongue cancer. A team consisting of a head and neck surgeon, a radiation oncologist, it medical oncologist, and a maternal-fetal medicine specialist was assembled. The patient initially refused surgery. Chemotherapy was initiated until 32 weeks' gestation. After an infant boy was delivered via cesarean section, the patient began concurrent irradiation and chemotherapy, which induced complete regression of the primary tongue neoplasm with a partial response of the neck nodes. The patient underwent bilateral neck dissection followed by hemiglossectomy for recurrence.
   Conclusions: Management of advanced oral carcinoma in pregnancy presents a unique set of challenges. Few studies have described chemotherapy and radiotherapy during pregnancy, and long-term results are needed. Care must be taken M to balance appropriate and adequate treatment of disease and to ensure the safety of the patient and the fetus,
C1 [Cheung, Esther J.; Fedok, Fred; Goldenberg, David] Penn State Hershey Med Ctr, Div Otolaryngol Head & Neck Surg, Dept Surg, Hershey, PA 17033 USA.
   [Wagner, Henry, Jr.] Penn State Hershey Med Ctr, Div Radiat Oncol, Dept Radiol, Hershey, PA 17033 USA.
   [Botti, John J.] Penn State Hershey Med Ctr, Div Maternal Fetal Med, Dept Obstet & Gynecol, Hershey, PA 17033 USA.
RP Goldenberg, D (reprint author), Penn State Hershey Med Ctr, Div Otolaryngol Head & Neck Surg, Dept Surg, 500 Univ Dr,MC H091, Hershey, PA 17033 USA.
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NR 29
TC 7
Z9 7
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD JAN
PY 2009
VL 118
IS 1
BP 21
EP 26
PG 6
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 399HT
UT WOS:000262791700004
PM 19244959
ER

PT J
AU Johnston, DR
   Curry, JM
   Rubin, R
   Rosen, MR
AF Johnston, Douglas R.
   Curry, Joseph M.
   Rubin, Raphael
   Rosen, Marc R.
TI Unusual Fibrosclerotic Lesion of the Laryngotracheal Complex Presenting
   as Subglottic Stenosis
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE fibrosclerosis; relapsing polychondritis; subglottic stenosis;
   tumefactive fibroinflammatory lesion
ID RETROPERITONEAL FIBROSIS; HEAD; NECK
AB We present a case report that describes the pathology, presentation, and management complexities of an Unusual, destructive fibrosclerotic lesion of the laryngotracheal complex. An otherwise healthy 21-year-old man presented with a 1-year history of progressive shortness of breath and stridor. The initial examination revealed a 3-cm, grade III subglottic stenosis. Nodular fibrosis of the strap muscles, laryngotracheal cartilages, and trachea was evident. Biopsies revealed dense peritracheal desmoplastic reaction with focal erosion of cartilage. However, features diagnostic for relapsing polychondritis, desmoid tumor, or orbital pseudotumor were absent. The disease progressed to involve severe stenosis and thickening of the trachea and main stem bronchi. Surgical and medical management of this unusual fibrosclerotic lesion did not meliorate the disease process, but a recent encouraging response to tamoxifen citrate has been observed with improvements in vocal fold motion and activity levels. Prognosis and management experience for this unknown pathologic entity are absent in the literature. In this case, diffuse disease progression Occurred despite surgical and medical management, but has been halted by tamoxifen therapy. The prospect of a durable response and disease remission is unknown.
C1 [Johnston, Douglas R.; Curry, Joseph M.; Rosen, Marc R.] Thomas Jefferson Univ Hosp, Dept Otolaryngol, Philadelphia, PA 19107 USA.
   [Rubin, Raphael] Thomas Jefferson Univ Hosp, Dept Pathol Anat & Cell Biol, Philadelphia, PA 19107 USA.
RP Rosen, MR (reprint author), Thomas Jefferson Univ, Dept Otolaryngol Head & Neck Surg, 925 Chestnut St,6th Floor, Philadelphia, PA 19107 USA.
CR BenHur H, 1997, CALCIFIED TISSUE INT, V60, P520, DOI 10.1007/s002239900274
   DUNN EJ, 1990, CHEST, V97, P338, DOI 10.1378/chest.97.2.338
   JONES KR, 2005, CUMMINGS OTOLARYNGOL, P2065
   Kuhn MA, 2002, J SURG RES, V103, P146, DOI 10.1006/jsre.2001.6350
   OLSEN KD, 1986, LARYNGOSCOPE, V96, P940
   Sekine S, 1999, PATHOL INT, V49, P663, DOI 10.1046/j.1440-1827.1999.00926.x
   Vaglio A, 2006, LANCET, V367, P241, DOI 10.1016/S0140-6736(06)68035-5
   Wang CP, 2006, HEAD NECK-J SCI SPEC, V28, P1008, DOI 10.1002/hed.20467
   WEISBERGER EC, 1985, OTOLARYNG HEAD NECK, V93, P536
   WOLD LE, 1983, AM J SURG PATHOL, V7, P477, DOI 10.1097/00000478-198307000-00010
NR 10
TC 0
Z9 3
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD JAN
PY 2009
VL 118
IS 1
BP 27
EP 29
PG 3
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 399HT
UT WOS:000262791700005
PM 19244960
ER

PT J
AU Sato, K
   Nakashima, T
AF Sato, Kiminori
   Nakashima, Tadashi
TI Sleep-Related Deglutition in Patients With Sleep Apnea-Hypopnea Syndrome
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE deglutition; nocturnal swallowing; respiratory phase pattern; sleep;
   sleep apnea-hypopnea syndrome; swallowing
ID PATTERN
AB Objectives: We investigated sleep-related deglutition in patients with obstructive sleep apnea-hypopnea syndrome (OSAHS).
   Methods: Deglutition during sleep was examined in 10 patients with a mean (+/-SD) age of 48 +/- 11 years who had severe OSAHS (apnea-hypopnea index, 66.6 17.6) via time-matched recordings of polysomnography and surface electromyoaraphy of the thyrohyoid and suprahyoid muscles.
   Results: During sleep, deglutition was episodic, and was absent for long periods. Deglutition did not occur during apnea or hypopnea periods. The mean number of swallows per hour during the total sleep time was 5.4 +/- 3.1. The mean period of the longest absence of deglutition was 43.5 +/- 14.7 minutes. Most deglutition occurred in association with respiratory electroencephalographic arousal after apnea or hypopnea. Approximately 70% of swallows were followed by inspiration. Deglutition was related to the sleep stage. The mean number of swallows per hour was 6.2 +/- 6.1 during stage 1 sleep, 6.0 +/- 3.4 during stage 2 sleep, 3.0 +/- 5.2 during stage 3 sleep, and 0 during stage 4 sleep. The deeper the sleep stage, the lower the mean deglutition frequency. The mean number of swallows per hour was 4.5 +/- 3.0 during rapid eye movement sleep.
   Conclusions: Deglutition was infrequent and displayed a unique pattern in patients with OSAHS during sleep.
C1 [Sato, Kiminori; Nakashima, Tadashi] Kurume Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, Kurume, Fukuoka 8300011, Japan.
RP Sato, K (reprint author), Kurume Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, 67 Asahi Machi, Kurume, Fukuoka 8300011, Japan.
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NR 14
TC 7
Z9 7
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD JAN
PY 2009
VL 118
IS 1
BP 30
EP 36
PG 7
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 399HT
UT WOS:000262791700006
PM 19244961
ER

PT J
AU Dickson, JM
   Richter, GT
   Meinzen-Derr, J
   Rutter, MJ
   Thompson, DM
AF Dickson, J. Matthew
   Richter, Gresham T.
   Meinzen-Derr, Jareen
   Rutter, Michael J.
   Thompson, Dana M.
TI Secondary Airway Lesions in Infants With Laryngomalacia
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE gastroesophageal reflux disease; laryngomalacia; stridor; subglottic
   stenosis; tracheomalacia
ID STRIDOR; ETIOLOGY; OBSTRUCTION; ENDOSCOPY; CHILDREN; REFLUX
AB Objectives: We sought to determine the incidence of secondary airway lesions in infants with laryngomalacia and to compare the incidences of these concomitant airway lesions in infants with severe, moderate, and mild laryngomalacia; to determine whether infants with mild or moderate laryngomalacia have a higher incidence of surgical intervention when a secondary airway lesion is present; and to determine whether the incidence of gastroesophageal reflux disease (GERD) is affected by the presence of a secondary airway lesion.
   Methods: We performed a retrospective review of a database consisting of 201 infants with a diagnosis of laryngomalacia treated at a pediatric tertiary referral center between June 1998 and June 2003. Data pertaining to demographic information, severity of laryngomalacia, presence of secondary airway lesions, and diagnosis of GERD were collected and analyzed.
   Results: Of the 201 infants, 104 (51.7%) were found to have a secondary airway lesion. Subglottic stenosis was found in 38.8%, and tracheomalacia in 37.8%. Of the infants with severe laryngomalacia, 30 (79%) had a diagnosis of a secondary lesion, compared with 5 1 (61.5%) of those with moderate and 23 (28.8%) of those with mild disease. Among infants with mild or moderate disease, those with secondary airway lesions were more likely to require surgical intervention than were infants without secondary airway lesions (27% versus 5.6%; p = 0.0002). There was no difference in the rates of secondary airway lesions in infants managed with supraglottoplasty versus tracheotomy. The incidence of GERD in this patient Population was 65.6%. Infants with a secondary airway lesion were more likely to have GERD than were those without a secondary airway lesion (84.6% versus 45.4%; p < 0.0001).
   Conclusions: The incidence of secondary airway lesions in Our Population of infants with laryngomalacia was higher than those previously reported. The severity of disease correlated with the diagnosis of a secondary airway lesion. Secondary airway lesions lead to an increased incidence Of Surgical intervention and GERD in infants with laryngomalacia.
C1 [Dickson, J. Matthew; Richter, Gresham T.; Meinzen-Derr, Jareen; Rutter, Michael J.; Thompson, Dana M.] Univ Cincinnati, Coll Med, Dept Pediat Otolaryngol, Cincinnati Childrens Hosp,Med Ctr, Cincinnati, OH USA.
   [Meinzen-Derr, Jareen] Univ Cincinnati, Coll Med, Ctr Biostat & Epidemiol, Cincinnati Childrens Hosp,Med Ctr, Cincinnati, OH USA.
   [Thompson, Dana M.] Mayo Eugenio Litta Childrens Hosp, Rochester, MN USA.
   [Thompson, Dana M.] Mayo Clin, Dept Otolaryngol, Div Pediat Otolaryngol, Rochester, MN 55902 USA.
RP Thompson, DM (reprint author), Mayo Clin, Dept Otolaryngol, Div Pediat Otolaryngol, 200 1st St SW, Rochester, MN 55902 USA.
CR BELMONT JR, 1984, ANN OTO RHINOL LARYN, V93, P430
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NR 23
TC 21
Z9 24
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD JAN
PY 2009
VL 118
IS 1
BP 37
EP 43
PG 7
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 399HT
UT WOS:000262791700007
PM 19244962
ER

PT J
AU Murugappan, S
   Khosla, S
   Casper, K
   Oren, L
   Gutmark, E
AF Murugappan, Shanmugam
   Khosla, Sid
   Casper, Keith
   Oren, Liran
   Gutmark, Ephraim
TI Flow Fields and Acoustics in a Unilateral Scarred Vocal Fold Model
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE phonation; vocal fold scarring; voice production; vortex
ID CANINE LARYNX MODEL
AB Objectives: From prior work in an excised canine larynx model, it has been shown that intraglottal vortices form between the vocal folds during the latter part of closing. It has also been shown that the vortices generate a negative pressure between the folds, producing a suction force that causes sudden, rapid closing of the folds. This rapid closing will produce increased loudness and increased higher harmonics. We used a unilateral scarred excised canine larynx model to determine whether the intraglottal vortices and resulting acoustics were changed, compared to those of normal larynges.
   Methods: Acoustic, flow field. and high-speed imaging measurements from 5 normal and 5 unilaterally scarred canine larynges are presented in this report. Scarring was produced by complete resection of the vocal fold mucosa and superficial layer of the lamina propria on the right vocal fold only. Two months later, these dogs were painlessly sacrificed, and testing was done on the excised larynges during phonation. High-speed video imaging was then used to measure vocal fold displacement during different phases. Particle image velocimetry and acoustic measurements were used to describe possible acoustic effects of the vortices.
   Results: A higher phonation threshold was required to excite the motion of the vocal fold in scarred larynges. As the Subglottal pressure increased, the strength of the vortices and the higher harmonics both consistently increased. However, it was seen that increasing the maximum displacement of the scarred fold did not consistently increase the higher harmonics. The improvements that result from increasing subglottal pressure may be due to a combination of increasing the strength of the intraglottal vortices and increasing the maximum displacement of the vocal folds however, the data in this study suggest that the vortices play a much more important role.
   Conclusions: The current Study indicates that higher subglottal pressures may excite higher harmonics and improve loudness for patients with unilateral vocal fold scarring. This finding implies that therapies that raise the subglottal pressure may be helpful in improving voice quality.
C1 [Murugappan, Shanmugam; Khosla, Sid; Casper, Keith; Gutmark, Ephraim] Univ Cincinnati, Med Ctr, Dept Otolaryngol Head & Neck Surg, Cincinnati, OH 45267 USA.
   [Oren, Liran; Gutmark, Ephraim] Univ Cincinnati, Dept Aerosp Engn & Engn Mech, Cincinnati, OH 45267 USA.
RP Murugappan, S (reprint author), Univ Cincinnati, Med Ctr, Dept Otolaryngol Head & Neck Surg, 231 Albert B Sabin Way,ML 0528, Cincinnati, OH 45267 USA.
FU National Institutes of Health/National Institute on Deafness and Other
   Communication Disorders [5K08DC005421]
FX From the Department of Otolarynoology-Head and Neck Surgery, University
   of Cincinnati Medical Center (Murugappan, Khosla, Casper, Gutmark), and
   the Department of Aerospace Engineering and Engineering Mechanics,
   University of Cincinnati (Oren, Gutmark), Cincinnati. Ohio. Supported by
   grant 5K08DC005421 from the National Institutes of Health/National
   Institute on Deafness and Other Communication Disorders. This study was
   performed in accordance with the PHS Policy on Humane Care and Use of
   Laboratory Animals, the NIH Guide for the Cart and Use of Laboratory
   Animals, and the Animal Welfare Act (7 U.S.C. et seq.); the animal use
   protocol was approved by the Institutional Animal Care and Use Committee
   (IACUC) of the University of Cincinnati.
CR Alipour F, 2004, J ACOUST SOC AM, V116, P1710, DOI 10.1121/1.1779274
   Behrman A., 2007, SPEECH VOICE SCI
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   Fant G., 1983, STL QPRS, V4, P1
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   Khosla S, 2008, CURR OPIN OTOLARYNGO, V16, P183, DOI 10.1097/MOO.0b013e3282ff5fc5
   Khosla S, 2008, ANN OTO RHINOL LARYN, V117, P134
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   Schlichting H, 1955, BOUNDARY LAYER THEOR
   Stevens K.N., 1998, ACOUSTIC PHONETICS
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NR 17
TC 14
Z9 14
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD JAN
PY 2009
VL 118
IS 1
BP 44
EP 50
PG 7
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 399HT
UT WOS:000262791700008
PM 19244963
ER

PT J
AU Ge, PJ
   French, LC
   Ohno, T
   Zealear, DL
   Rousseau, B
AF Ge, Ping Jiang
   French, Lesley C.
   Ohno, Tsunehisa
   Zealear, David L.
   Rousseau, Bernard
TI Model of Evoked Rabbit Phonation
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE in vivo model; phonation intensity; rabbit
ID RECURRENT LARYNGEAL NERVE; VOCAL FOLD; ELECTRICAL-STIMULATION; MUSCLES
AB Objectives: We describe a method for eliciting phonation in an in vivo rabbit preparation using low-frequency, bipolar pulsed stimulation of the cricothyroid muscles with airflow delivered to the glottis.
   Methods: Ten New Zealand White breeder rabbits weighing 3 to 5 kg were used in this study. The cricothyroid muscles were isolated bilaterally, and separate pairs of anode-cathode hooked-wire electrodes were inserted into each Muscle. A Grass S-88 stimulator and 2 constant-current PSIU6 isolation units were used to deliver bipolar square wave pulses to each cricothyroid muscle, with airflow delivered to the glottis through a Cuffed endotracheal tube.
   Results: Phonation was evoked with a 50-Hz, 4-mA stimulus train of 1-ms pulses delivered to each cricothyroid muscle. The pulse trains were oil for 2 seconds and were repeated every 5 seconds over a period Of 180 Minutes. Airflow was delivered at 143 cm(3)/s, producing phonation measuring 71 to 85 dB Sound pressure level.
   Conclusions: Evoked phonation is feasible in rabbits by use of bipolar stimulation of the cricothyroid muscles with airflow delivered to the glottis. The in vivo rabbit preparation described may provide a useful small animal option for studies of evoked phonation. From the level and consistency of the adduction observed, we hypothesize that current spreading to the underlying adductor muscles and nerves resulted in neural pathway involvement beyond discrete activation of the cricothyroid muscle, providing sufficient approximation of the vocal folds for phonation.
C1 [Ge, Ping Jiang; French, Lesley C.; Ohno, Tsunehisa; Zealear, David L.; Rousseau, Bernard] Vanderbilt Univ, Dept Otolaryngol, Bill Wilkerson Ctr Otolaryngol & Commun Sci, Nashville, TN 37232 USA.
   [Ge, Ping Jiang] Guangdong Prov Peoples Hosp, Dept Otolaryngol, Guangzhou, Guangdong, Peoples R China.
RP Rousseau, B (reprint author), Vanderbilt Univ, Dept Otolaryngol, Bill Wilkerson Ctr Otolaryngol & Commun Sci, 1313 21st Ave S,Room 602, Nashville, TN 37232 USA.
FU NIH [R03 DC 008400]; National Institute oil Deafness and Other
   Communication Disorders
FX From the Department of Otolarynggology, Vanderbilt University Bill
   Wilkerson Center for Otolaryngology and Communication Sciences,
   Nashville, Tennessee (all authors), and the Department of
   Otolaryngology, Guangdong Province People's Hospital, Guangzhou, China
   (Ge). This research was supported by NIH grant R03 DC 008400 from the
   National Institute oil Deafness and Other Communication Disorders. This
   Study was performed in accordance with the PHS Policy oil Humane Care
   and Use of Laboratory Animals. the NIH Guide for the Care and Use of
   Laboratory Animals, and the Animal Welfare Act (7 U.S.C. et seq.); the
   animal use protocol was approved by the Institutional Animal Care and
   Use Committee (IACUC) of Vanderbilt University.
CR BERKE GS, 1987, LARYNGOSCOPE, V97, P871
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NR 16
TC 12
Z9 13
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD JAN
PY 2009
VL 118
IS 1
BP 51
EP 55
PG 5
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 399HT
UT WOS:000262791700009
PM 19244964
ER

PT J
AU Scott, AR
   Chong, PST
   Brigger, MT
   Randolph, GW
   Hartnick, CJ
AF Scott, Andrew R.
   Chong, Peter Slao Tick
   Brigger, Matthew T.
   Randolph, Gregory W.
   Hartnick, Christopher J.
TI Serial Electromyography of the Thyroarytenoid Muscles Using the
   NIM-Response System in a Canine Model of Vocal Fold Paralysis
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE laryngeal electromyography; recurrent laryngeal nerve; vocal fold
   paralysis
ID LARYNGEAL ELECTROMYOGRAPHY; CORD PARALYSIS; CHILDREN; MANAGEMENT;
   IMMOBILITY
AB Objectives: We sought to determine whether serial intraoperative laryngeal electromyography (L-EMG) or evoked L-EMG predicts vocal fold (VF) recovery following iatrogenic injury.
   Methods: Six beagles were sedated, and bipolar needle electrodes were inserted into each thyroarytenoid (TA) muscle. Endotracheal tube surface electrodes were also placed. As the sedation lightened, L-EMG activity was recorded from all electrodes with an intraoperative nerve monitoring system. The neck was opened, and direct recurrent laryngeal nerve (RLN) stimulation was performed. Subsequently, 4 animals underwent crush injury of the left RLN, and 2 animals underwent nerve transection. The L-EMG procedures were repeated every I to 2 weeks until left VF motion was observed in the dogs that suffered RLN crush injury. At each time point, the neck was opened and both RLNs were stimulated.
   Results: Fibrillation potentials were detected in all animals after RLN injury. A change to electrical silence was seen in the animals in the crush injury group that were evaluated during the week preceding VF recovery. Fibrillation potentials and VF immobility persisted in the transection group throughout the complete time course of these experiments. The first appearance of an evoked response coincided with or occurred after the return of left VF motion in the crush injury group. The threshold, latency, and amplitude differed from those of the controls and approached normal values over time. No response was detected in the transected nerves.
   Conclusions: The disappearance of fibrillations on intraoperative L-EMG was noted in the animals tested the week before the return of VF motion, and the return of motor unit action potentials was seen along with return of VF function. Evoked L-EMG was not helpful in predicting the return of VF mobility, but it may help quantify degrees of RLN injury and predict the speed of recovery.
C1 [Scott, Andrew R.; Brigger, Matthew T.; Randolph, Gregory W.; Hartnick, Christopher J.] Massachusetts Eye & Ear Infirm, Dept Otol & Laryngol, Boston, MA 02114 USA.
   [Chong, Peter Slao Tick] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Dept Neurol, Boston, MA USA.
RP Hartnick, CJ (reprint author), Massachusetts Eye & Ear Infirm, Dept Otol & Laryngol, 243 Charles St, Boston, MA 02114 USA.
CR Berkowitz RG, 1996, ANN OTO RHINOL LARYN, V105, P207
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   Zealear DL, 2005, ANN OTO RHINOL LARYN, V114, P563
NR 17
TC 6
Z9 6
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD JAN
PY 2009
VL 118
IS 1
BP 56
EP 66
PG 11
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 399HT
UT WOS:000262791700010
PM 19244965
ER

PT J
AU Shimizu, S
   Hattori, R
   Majima, Y
   Shimizu, T
AF Shimizu, Shino
   Hattori, Reiko
   Majima, Yuichi
   Shimizu, Takeshi
TI Th2 Cytokine Inhibitor Suplatast Tosilate Inhibits Antigen-Induced Mucus
   Hypersecretion in the Nasal Epithelium of Sensitized Rats
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE allergy; eosinophil; goblet cell; mucus hypersecretion; rat nose; Th2
   cytokine
ID GOBLET-CELL METAPLASIA; EOSINOPHILIC INFLAMMATION; DIMETHYLSULFONIUM
   AGENT; GENE-EXPRESSION; IGE PRODUCTION; IN-VIVO; ASTHMA; MICE;
   SUPPRESSION; IPD-1151T
AB Objectives: Th2 cytokines such as interleukin (IL) 4 and IL-13 are potential mediators for mucus hypersecretion in allergic inflammation. To elucidate the functions of Th2 cytokines in allergic rhinitis, we examined the in vivo effects of the Th2 cytokine inhibitor suplatast tosilate on mucus hypersecretion and eosinophil infiltration in rat nasal epithelium.
   Methods: We induced hypertrophic and metaplastic changes in goblet cells in the nasal epithelium of ovalbumin-sensitized rats by intranasal challenge with ovalbumin. The effects of orally administered suplatast tosilate on mucus production and eosinophil infiltration were examined.
   Results: Suplatast tosilate (30 and 100 mg/kg) dose-dependently inhibited ovalbumin-induced mucus production and eosinophil infiltration. These suppressions of mucus production and eosinophil infiltration were only effective when suplatast tosilate was given in the effector phase; administration in the induction phase resulted in no effect.
   Conclusions: These results indicate that Th2 cytokines are important mediators of mucus hypersecretion and eosinophil infiltration in allergic rhinitis. Suplatast tosilate may be useful for the treatment of allergic rhinitis by attenuating the inflammation of the effector phase.
C1 [Shimizu, Shino; Shimizu, Takeshi] Shiga Univ Med Sci, Dept Otorhinolaryngol, Otsu, Shiga 52021, Japan.
   [Hattori, Reiko; Majima, Yuichi] Mie Univ, Sch Med, Dept Otorhinolaryngol Head & Neck Surg, Tsu, Mie 514, Japan.
RP Shimizu, T (reprint author), Shiga Univ Med Sci, Dept Otorhinolaryngol, Shiga 5202192, Japan.
FU Ministry of Education, Culture, Sports, Science and Technology of Japan,
   Tokyo [20591999]
FX From the Department of Otorhinolaryngology, Shiga University of Medical
   Science, Otsu (S. Shimizu, T. Shimizu), and the Department of
   Otorhinolaryngology-Head and Neck Surgery, Mie University School of
   Medicine, Tsu (Hattori. Majima), Japan. This study was supported by
   Grant-in-Aid for General Scientific Research No. 20591999 from the
   Ministry of Education, Culture, Sports, Science and Technology of Japan,
   Tokyo.
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NR 22
TC 5
Z9 5
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD JAN
PY 2009
VL 118
IS 1
BP 67
EP 72
PG 6
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 399HT
UT WOS:000262791700011
PM 19244966
ER

PT J
AU Hydrnan, J
   Mattsson, P
AF Hydrnan, Jonas
   Mattsson, Per
TI Preserved Regeneration and Functional Recovery of the Injured Recurrent
   Laryngeal Nerve After Secondary Surgical Repair in Adult Rats
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE posterior cricoarytenoid muscle; recurrent laryngeal nerve;
   reinnervation
ID NUCLEUS AMBIGUUS; CONDITIONING LESION; AXONAL OUTGROWTH;
   MOLECULAR-BASIS; MOTONEURON LOSS; SCIATIC-NERVE; GENE-TRANSFER;
   FACIAL-NERVE; VOCAL CORD; NIMODIPINE
AB Objectives: Transection of the recurrent laryngeal nerve (RLN) is accompanied by poor functional recovery, despite primary repair, because of regeneration difficulties. Nimodipine can promote regeneration, but it is not yet clear whether preoperative treatment is necessary. It is also not clear whether surgical repair following RLN injury may be performed ill a second procedure, with preserved regeneration. This study investigated the time window for secondary surgical repair of the transected RLN and the need for preoperative administration of nimodipille.
   Methods: In adult rats, the left RLN was transected and repaired at time intervals LIP to 3 weeks after transection, ill combination with nimodipine treatment starting either before or after the operation. Regeneration and neuromuscular recovery were assessed by electrophysiology, retrograde tracing, and immunohistochemistry.
   Results: Similar (whether 0, 2, or 7 days) regenerative results were obtained when the RLN was repaired up to 1 week after injury, given nimodipine administration, whereas fewer motor neurons managed to regenerate after nerve repair at 3 weeks after the initial transection. No beneficial effect was detected from preoperative nimodipine administration.
   Conclusions: Provided that nimodipine is administered, surgical reconstruction of the RLN can be performed within I week after the initial nerve trauma, with preserved neuromuscular function. Nimodipine may be administered at the time of RLN transection injury.
C1 [Hydrnan, Jonas; Mattsson, Per] Karolinska Inst, Neurosurg Sect, Dept Clin Neurosci, Stockholm, Sweden.
RP Hydrnan, J (reprint author), Karolinska Univ Hosp, Sect Neurosurg R2 02, Dept Clin Neurosci, S-17176 Stockholm, Sweden.
FU Socialstyrelsen; Magnus Bergvalls Foundation; Swedish Medical Research
   Council; Karolinska Institutet Foundation; Soderbergs Foundation
FX From the Department of Clinical Neuroscience, Section of Neurosurgery,
   Karolinska Institutet, Stockholm, Sweden. Funded by the Socialstyrelsen,
   the Magnus Bergvalls Foundation, the Swedish Medical Research Council,
   the Karolinska Institutet Foundation, and the Soderbergs Foundation.
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NR 36
TC 0
Z9 0
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD JAN
PY 2009
VL 118
IS 1
BP 73
EP 80
PG 8
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 399HT
UT WOS:000262791700012
ER

PT J
AU Lee, L
   Pensak, ML
AF Lee, Lisa
   Pensak, Myles L.
TI Contemporary Role of Endolymphatic Mastoid Shunt Surgery in the Era of
   Transtympanic Perfusion Strategies
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE endolymphatic hydrops; endolymphatic mastoid shunt; Meniere's disease
ID UNILATERAL MENIERES-DISEASE; INTRATYMPANIC GENTAMICIN THERAPY; SAC
   DECOMPRESSION; FOLLOW-UP; DEXAMETHASONE; VERTIGO; QUESTIONNAIRE;
   INJECTIONS; OUTCOMES
AB Objectives: Although there exist undisputed methods to permanently silence the aberrant end organ, controversy Surrounds the durable efficacy of non-ablative interventions. This study provides a contemporary review of our institution's clinical experience in performing endolymphatic mastoid shunt surgery (EMSS) in patients with medically refractory endolymphatic hydrops, or Meniere's disease.
   Methods: Between 1984 and 2002, 1,612 patients were referred to our institution with a diagnosis of Meniere's disease. Of these referrals, 1, 172 patients met the criteria for Meniere's disease. Although 553 patients responded to medical management, 486 patients underwent EMSS and 133 patients had refractory disease that required chemical or surgical obliterative interventions. The retrospective study utilizes data collected on 226 patients who were followed for a minimum of 5 years.
   Results: Overall, 78% patients responded favorably to EMSS, according to the functional level scale and class categories delineated by the American Academy of Otolaryngology-Head and Neck Surgery 1995 guidelines for control of vertigo. According to the Arenberg anatomic classification for endolymphatic sac location, EMSS achieved adequate control of vertigo in 86% of type I cases, 90% of type II cases, and 82% of type III cases.
   Conclusions: Endolymphatic mastoid shunt surgery is a relatively safe, effective procedure for the long-term control of vertigo in patients with medically refractory Meniere's disease.
C1 [Lee, Lisa; Pensak, Myles L.] Univ Cincinnati, Acad Hlth Ctr, Dept Otolaryngol Head & Neck Surg, Cincinnati, OH 45267 USA.
RP Pensak, ML (reprint author), Univ Cincinnati, Acad Hlth Ctr, Dept Otolaryngol Head & Neck Surg, 231 Albert Sabin Way,Rm 6507 MSB,POB 670528, Cincinnati, OH 45267 USA.
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NR 31
TC 4
Z9 4
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD DEC
PY 2008
VL 117
IS 12
BP 871
EP 875
PG 5
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 386AX
UT WOS:000261855800001
PM 19140530
ER

PT J
AU Deguchi, S
   Kawashima, K
   Washio, S
AF Deguchi, Shinji
   Kawashima, Kazutaka
   Washio, Seiichi
TI Computer-Aided Technique for Automatic Determination of the Relationship
   Between Transglottal Pressure Change and Voice Fundamental Frequency
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE computer-aided diagnosis; fundamental frequency of phonation; noncontact
   measurement; transglottal pressure; vocal fold stiffness
ID VOCAL FOLD; ELASTIC PROPERTIES; PHONATION; SIGNALS; PITCH
AB Objectives: The effect of artificially altered transglottal pressures on the voice fundamental frequency (170) is known to be associated with vocal fold stiffness. Its measurement, though useful as a potential diagnostic tool for noncontact assessment of vocal fold stiffness, often requires manual and painstaking determination of an unstable F0 of voice. Here, we provide a computer-aided technique that enables one to carry out the determination easily and accurately.
   Methods: Human subjects vocalized in accordance with a series of reference sounds from a speaker controlled by a computer. Transglottal pressures were altered by means of a valve embedded in a mouthpiece. Time-varying vocal F0 was extracted, without manual procedures, from a specific range of the voice spectrum determined on the basis of the controlled reference sounds.
   Results: The validity of the proposed technique was assessed for II healthy subjects. Fluctuating voice F0 was tracked automatically during experiments, providing the relationship between transglottal pressure change and F0 on the computer.
   Conclusions: The proposed technique overcomes the difficulty in automatic determination of the voice F0, which tends to be transient both in normal voice and in some types of pathological voice.
C1 [Deguchi, Shinji] Tohoku Univ, CRESS, Sendai, Miyagi 9808579, Japan.
   [Deguchi, Shinji] Tohoku Univ, Grad Sch Biomed Engn, Sendai, Miyagi 9808579, Japan.
   [Kawashima, Kazutaka; Washio, Seiichi] Okayama Univ, Grad Sch Nat Sci & Technol, Okayama 7008530, Japan.
RP Deguchi, S (reprint author), Tohoku Univ, CRESS, 6-6-11-1306-2 Aramaki Aoba, Sendai, Miyagi 9808579, Japan.
FU Sound Technology Promotion Foundation; Japan Ministry of Education,
   Culture, Sports, Science, and Technology
FX This work was supported in part by the Sound Technology Promotion
   Foundation and a Grant-in-Aid for Scientific Research from the Japan
   Ministry of Education, Culture, Sports, Science, and Technology.
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NR 16
TC 0
Z9 0
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD DEC
PY 2008
VL 117
IS 12
BP 876
EP 880
PG 5
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 386AX
UT WOS:000261855800002
PM 19140531
ER

PT J
AU Kishimoto, Y
   Hirano, S
   Kato, N
   Suehiro, A
   Kanemaru, S
   Ito, J
AF Kishimoto, Yo
   Hirano, Shigeru
   Kato, Naomi
   Suehiro, Atsushi
   Kanemaru, Shin-ichi
   Ito, Juichi
TI Endoscopic KTP Laser Photocoagulation Therapy for Pharyngolaryngeal
   Venous Malformations in Adults
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE adult pharyngolaryngeal venous malformation; KTP laser; photocoagulation
   therapy; potassium titanyl phosphate laser
ID SUBGLOTTIC HEMANGIOMA; VOCAL FOLD; YAG LASER; MANAGEMENT; CO2-LASER;
   LESIONS; LARYNGEAL; EXCISION
AB Objectives: Venous malformations are benign lesions with thin, fragile mucosa overlying a vascular stroma. Vascular anomalies often manifest as subglottic lesions in infants, but venous malformations in adults are rare in the pharyngolaryngeal region. The treatments include open and endoscopic surgery; intraoperative bleeding is often troublesome. Angiolytic lasers such as the potassium titanyl phosphate (KTP) laser enable photocoagulation for such hemorrhagic lesions without bleeding; we report findings from a series of adult patients.
   Methods: Seven adults were treated with a KTP laser set at a low power of 1.5 W in continuous mode. Photocoagulation was easily performed for shallow lesions; however, laser irradiation of bulky venous malformations resulted only in surface photocoagulation. In such cases, the crust remaining after photocoagulation was removed, and laser energy was repeatedly delivered until no remnant lesion was seen. An office procedure using flexible endoscopy was performed under topical anesthesia for I patient with a limited lesion.
   Results: The lesions were well controlled in all cases without major complications. A patient with a large obstructing lesion had a relapse. Because the recurrent lesion is small and the patient does not desire additional treatment at this time, she is being observed carefully.
   Conclusions: Photocoagulation using the KTP laser is a feasible and relatively safe treatment for pharyngolaryngeal venous malformations in adults.
C1 [Hirano, Shigeru] Kyoto Univ, Grad Sch Med, Dept Otolaryngol Head & Neck Surg, Sakyo Ku, Kyoto 6068507, Japan.
   [Kato, Naomi] Kyoto Minami Hosp, Dept Otolaryngol, Kyoto, Japan.
RP Hirano, S (reprint author), Kyoto Univ, Grad Sch Med, Dept Otolaryngol Head & Neck Surg, Sakyo Ku, Kyoto 6068507, Japan.
CR Cholewa D, 1998, LASER SURG MED, V23, P221, DOI 10.1002/(SICI)1096-9101(1998)23:4<221::AID-LSM5>3.0.CO;2-A
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NR 11
TC 14
Z9 14
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD DEC
PY 2008
VL 117
IS 12
BP 881
EP 885
PG 5
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 386AX
UT WOS:000261855800003
PM 19140532
ER

PT J
AU O'Brien, TJ
   Parham, K
AF O'Brien, Timothy J.
   Parham, Kourosh
TI Transnasal Esophagoscopy: White-Light Versus Narrowband Imaging
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE Barrett's esophagus; laryngopharyngeal reflux; narrowband imaging;
   transnasal esophagoscopy
ID DOCUMENTED LARYNGOPHARYNGEAL REFLUX; BARRETTS-ESOPHAGUS; SURVEILLANCE;
   PREVALENCE; ENDOSCOPY; SYMPTOMS; UTILITY
AB Objectives: Transnasal esophagoscopy (TNE) is rapidly becoming integrated into otolaryngological practice. A recent report has shown an incongruence between an endoscopic diagnosis of Barrett's esophagus and biopsy-proven Barrett's esophagus in patients with laryngopharyngeal reflux (LPR). The goal of this study was to determine whether performing TNE with narrowband imaging (NBI) improves on the diagnostic yield in the otolaryngologist's hands. Narrowband imaging involves the use of filtered light to enhance the mucosal microvasculature pattern and has been shown to be highly sensitive to detecting Barrett's esophagus under conventional esophagoscopy.
   Methods: A retrospective chart review of I I I patients with LPR who underwent TNE by the same otolaryngologist was carried out. Pentax EE-1580K (white light only) and Olympus GIF-N180 (with NBI) endoscopes were used in 58 and 53 patients, respectively. Microcup biopsy of the squamocolumnar junction was obtained when Barrett's esophagus was suspected.
   Results: Biopsy-proven Barrett's esophagus was found in 13.5% of the patients. According to white light only and NBI, 7 of 58 (12. 1 %) and 8 of 53 (15. 1 %), respectively, had biopsy-proven Barrett's esophagus. Three patients had dysplasia on biopsy (2.7%), and all of these cases were detected under NBI (5.7%).
   Conclusions: Narrowband imaging may be a useful adjunct in increasing the diagnostic sensitivity of TNE in the hands of the otolaryngologist.
C1 [O'Brien, Timothy J.; Parham, Kourosh] UCHC, Div Otolaryngol, Dept Surg, Farmington, CT 06030 USA.
RP Parham, K (reprint author), UCHC, Div Otolaryngol, Dept Surg, 263 Farmington Ave, Farmington, CT 06030 USA.
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NR 17
TC 3
Z9 3
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD DEC
PY 2008
VL 117
IS 12
BP 886
EP 890
PG 5
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 386AX
UT WOS:000261855800004
PM 19140533
ER

PT J
AU Birchall, MA
   Bailey, M
   Gutowska-Owsiak, D
   Johnston, N
   Inman, CF
   Stokes, CR
   Postma, G
   Pazmany, L
   Koufman, JA
   Phillips, A
   Rees, LE
AF Birchall, Martin A.
   Bailey, Michael
   Gutowska-Owsiak, Danuta
   Johnston, Nikki
   Inman, Charlotte F.
   Stokes, Christopher R.
   Postma, Gregory
   Pazmany, Laszlo
   Koufman, Jamie A.
   Phillips, Anne
   Rees, Louisa E.
TI Immunologic Response of the Laryngeal Mucosa to Extraesophageal Reflux
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE CD1d; extraesophageal reflux; iGb3; NKT cell
ID LARYNGOPHARYNGEAL REFLUX; NKT CELLS; ARCHITECTURE; EPITHELIUM;
   EXPRESSION; DISEASE
AB Objectives: Extraesophageal reflux is common. The treatment costs are high, and there are associations with other diseases, including laryngeal cancer. Our studies of the mucosal immune response to this common inflammatory disease suggest an important role for the nonclassic antigen-presenting molecule CD1d in the response to inflammation. This study was performed to further explore the relationship between the CD1d-NKT cell-iGb3 axis and reflux.
   Methods: We carried out a prospective study of laryngeal biopsies from 12 patients with laryngopharyngeal reflux and I I controls. Quantitative multiple-color immunofluorescence using antibodies for lymphocytes (CD3, CD161) and classic and nonclassic major histocompatibility complex (I, II, beta 2m, CD1d) was per-formed, and univariate and multivariate analysis and co-localization measurements were applied.
   Results: Epithelial major histocompatibility complex class I and II expression was unchanged by reflux, but expression of CD1d increased (p < 0.05; luminal layers) and confidence intervals diminished in the reflux group. Co-localization of NKT cells with CD1d increased in patients (p < 0.01); iGb3 exhibited strong expression throughout all layers of the laryngeal epithelium.
   Conclusions: These data indicate a role for the CD1d-NKT cell-iGb3 axis in response to extraesophageal reflux in humans. This represents a useful target for novel diagnostics and treatments for this common condition.
C1 [Birchall, Martin A.; Phillips, Anne; Rees, Louisa E.] Univ Bristol, Laryngeal Res Grp, Bristol BS40 5DU, Avon, England.
   [Bailey, Michael; Inman, Charlotte F.; Stokes, Christopher R.; Phillips, Anne; Rees, Louisa E.] Univ Bristol, Fac Med & Vet Sci, Bristol BS40 5DU, Avon, England.
   [Gutowska-Owsiak, Danuta; Pazmany, Laszlo] Univ Liverpool, Div Med, Liverpool L69 3BX, Merseyside, England.
   [Johnston, Nikki] Med Coll Wisconsin, Dept Otolaryngol & Commun Sci, Milwaukee, WI 53226 USA.
   [Postma, Gregory] Med Coll Georgia, Dept Otolaryngol, Ctr Voice & Swallowing Disorders, Augusta, GA 30912 USA.
   [Koufman, Jamie A.] Voice Inst New York, New York, NY USA.
RP Rees, LE (reprint author), Univ Bristol, Laryngeal Res Grp, Langford House, Bristol BS40 5DU, Avon, England.
FU Courtenay-Cowlin Fellowship (University of Bristol); Wellcome Trust
FX Dr Rees was supported by a Courtenay-Cowlin Fellowship (University of
   Bristol), and Dr Birchall was supported by a Research Clinical Leave
   Fellowship from the Wellcome Trust.
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NR 13
TC 7
Z9 7
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD DEC
PY 2008
VL 117
IS 12
BP 891
EP 895
PG 5
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 386AX
UT WOS:000261855800005
PM 19140534
ER

PT J
AU Oestreicher-Kedem, Y
   DeRowe, A
   Nagar, H
   Fishman, G
   Ben-Ari, J
AF Oestreicher-Kedem, Yael
   DeRowe, Ari
   Nagar, Hagit
   Fishman, Gad
   Ben-Ari, Josef
TI Vocal Fold Paralysis in Infants With Tracheoesophageal Fistula
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE tracheoesophageal fistula; vocal fold paralysis
ID RECURRENT LARYNGEAL NERVE; ESOPHAGEAL ATRESIA; CORD PARALYSIS;
   THORACOSCOPIC REPAIR; SURGERY; MANAGEMENT; CHILDREN; NEWBORN
AB Objectives: We describe the clinical characteristics and management of vocal fold paralysis in infants who were born with a tracheoesophageal fistula (TEF).
   Methods: This retrospective case series included all infants born with TEFs who presented to our pediatric otolaryngology unit and intensive care unit because of dyspnea or aphonia in the years 2005 and 2006, and who were found to have vocal fold paralysis.
   Results: Five boys and I girl were studied. One infant had stridor before TEF repair, and 5 after it. All children underwent flexible laryngotracheobronchoscopy and were treated in the pediatric intensive care unit before diagnosis of the vocal fold paralysis (5 bilaterally and I unilaterally) was made. The ages at diagnosis of paralysis ranged between 14 days and 14 months. Five infants required tracheostomy.
   Conclusions: Vocal fold paresis in infants is difficult to diagnose. The risk for recurrent laryngeal nerve injury associated with TEF and TEF repair should be emphasized in these children. We recommend that all newborns with TEF should be examined by an otolaryngologist before operation to confirm the mobility of the vocal folds and to rule out other associated airway malformations, and examined after operation if respiratory difficulties develop.
C1 [Oestreicher-Kedem, Yael; DeRowe, Ari; Fishman, Gad] Tel Aviv Univ, Pediat Otolaryngol Unit, IL-69978 Tel Aviv, Israel.
   [Nagar, Hagit] Tel Aviv Univ, Dept Pediat Surg, IL-69978 Tel Aviv, Israel.
   [Ben-Ari, Josef] Tel Aviv Univ, Intens Care Unit, Dana Childrens Hosp, Tel Aviv Sourasky Med Ctr,Sackler Sch Med, IL-69978 Tel Aviv, Israel.
RP Oestreicher-Kedem, Y (reprint author), 28 He Beiyar St, Tel Aviv, Israel.
EM dkyo@013.net
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NR 33
TC 6
Z9 7
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD DEC
PY 2008
VL 117
IS 12
BP 896
EP 901
PG 6
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 386AX
UT WOS:000261855800006
PM 19140535
ER

PT J
AU Galli, J
   Calo, L
   Ardito, F
   Imperiali, M
   Bassotti, E
   Passali, GC
   La Torre, G
   Paludetti, G
   Fadda, G
AF Galli, Jacopo
   Calo, Lea
   Ardito, Fausta
   Imperiali, Micaela
   Bassotti, Ezio
   Passali, Giulio Cesare
   La Torre, Giuseppe
   Paludetti, Gaetano
   Fadda, Giovanni
TI Damage to Ciliated Epithelium in Chronic Rhinosinusitis: What Is the
   Role of Bacterial Biofilms?
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE bacterial biofilm; chronic rhinosinusitis; functional endoscopic sinus
   surgery; respiratory epithelium
ID PSEUDOMONAS-AERUGINOSA; INFECTIONS; SINUSITIS; MUCOSA; CELLS
AB Objectives: We assess the association between the presence of biofilms and cilial damage in patients with chronic rhinosinusitis (CRS), describe the microorganisms associated with samples that exhibited cilial loss and biofilms, and demonstrate the absence of ciliary injury and biofilms in similarly prepared "normal" controls.
   Methods: We examined samples of ethmoid mucosa obtained from 24 patients who underwent functional endoscopic sinus surgery for CRS. Samples from a control group (20 healthy subjects) were also examined. The specimens were divided into 2 fragments; the first was processed for bacterial cultures, and the second was subjected to scanning electron microscopy. Statistical analysis was performed.
   Results: All CRS samples had positive bacterial cultures. The scanning electron microscopy analysis showed bacterial biofilms in 10 of the 24 specimens. A marked destruction of the epithelium was observed in samples positive for biofilms (p < 0.001), and the presence of Haemophilus influenzae was associated with ciliary abnormalities (partial damage in 55.6% and absence of cilia in 50%; p = 0.041).
   Conclusions: The high percentage of biofilms in our specimens confirms the association between biofilms and CRS. Our data support the hypothesis that biofilm formation represents the latter phase of an inflammatory process that leads to complete epithelial destruction.
C1 [Galli, Jacopo; Calo, Lea; Imperiali, Micaela; Passali, Giulio Cesare; Paludetti, Gaetano] Univ Cattolica Sacro Cuore, Inst Otorhinolaryngol, I-00168 Rome, Italy.
   [Ardito, Fausta; Fadda, Giovanni] Univ Cattolica Sacro Cuore, Inst Microbiol, I-00168 Rome, Italy.
   [Bassotti, Ezio] Univ Cattolica Sacro Cuore, Inst Odontostomatol, I-00168 Rome, Italy.
   [La Torre, Giuseppe] Univ Cattolica Sacro Cuore, Inst Hyg & Epidemiol, I-00168 Rome, Italy.
RP Calo, L (reprint author), Univ Cattolica Sacro Cuore, A Gemelli Univ Hosp, Inst Otorhinolaryngol, Lgo Gemelli 8, I-00168 Rome, Italy.
RI Fadda, Giovanni/K-6224-2012
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NR 17
TC 18
Z9 19
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD DEC
PY 2008
VL 117
IS 12
BP 902
EP 908
PG 7
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 386AX
UT WOS:000261855800007
PM 19140536
ER

PT J
AU Wang, JH
   Lee, JH
   Han, JH
   Lee, BJ
   Jang, YJ
AF Wang, Jong Hwan
   Lee, Jeong Hyun
   Han, Ju Hee
   Lee, Bong-Jae
   Jang, Yong Ju
TI Contralateral Maxillary Sinus Lesions in Patients With Nasal Cavity
   and/or Paranasal Sinus Carcinoma: Analysis of Computed Tomography
   Findings
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE bilateral carcinoma; carcinoma; computed tomography; contralateral
   lesion; paranasal sinus
ID SQUAMOUS-CELL CARCINOMA; POSITRON-EMISSION-TOMOGRAPHY; 2ND PRIMARY;
   MALIGNANT-TUMORS; CT; NECK; HEAD; RHINOSINUSITIS; DIAGNOSIS; CANCER
AB Objectives: The incidence of bilateral maxillary sinus carcinoma is very low in patients with primary maxillary sinus carcinoma. However, surgeons should perform careful diagnosis of any contralateral maxillary sinus lesions to avoid missing a second primary maxillary sinus carcinoma. We therefore investigated the computed tomography (CT) findings of the contralateral maxillary sinus in patients with nasal cavity and/or paranasal sinus carcinoma.
   Methods: Between August 1994 and September 2006, 66 patients (41 male, 25 female; age range, 22 to 85 years; mean age, 56.9 years) with nasal and/or paranasal sinus carcinoma were treated. Preoperative and follow-up CT scans of their contralateral maxillary sinuses were retrospectively reviewed.
   Results: Of the 66 patients, 26 (39.4%) had rhinosinusitis, 6 (9.1 %) had retention cysts, and 33 (50.0%) showed normal findings on CT. One patient (1.5%) had bilateral enhanced mass-like lesions. Both masses were diagnosed histologically as poorly differentiated squamous cell carcinoma. The rhinosinusitis findings included mucoperiosteal thickening, sclerotic bone thickening, hyperdense secretion, and an air-fluid level, in order of decreasing frequency. Twenty-three of the 32 patients with benign lesions were included in the follow-up CT analysis, ranging from 24 to 108 months (mean, 45 months). On the final CT scan, rhinosinusitis was aggravated in 5 of 19 cases and improved in 14 cases, and the size of the retention cyst decreased in 4 cases. During the follow-up period, no definite abnormality suggesting tumor development in the contralateral maxillary sinus was detected.
   Conclusions: Even though most contralateral maxillary sinus lesions are benign and the incidence of bilateral maxillary sinus carcinoma is very low, second primary maxillary sinus carcinoma should be kept in mind in the differential diagnosis of contralateral maxillary sinus lesions in patients with nasal cavity and/or paranasal sinus carcinoma.
C1 [Wang, Jong Hwan; Han, Ju Hee; Lee, Bong-Jae; Jang, Yong Ju] Univ Ulsan, Coll Med, Dept Otolaryngol, Asan Med Ctr, Seoul 138736, South Korea.
   [Han, Ju Hee] Univ Ulsan, Coll Med, Dept Radiol, Asan Med Ctr, Seoul 138736, South Korea.
RP Jang, YJ (reprint author), Univ Ulsan, Coll Med, Dept Otolaryngol, Asan Med Ctr, 388-1 Pungnap-2Dong, Seoul 138736, South Korea.
CR Bhattacharyya N, 2003, LARYNGOSCOPE, V113, P125, DOI 10.1097/00005537-200301000-00023
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NR 17
TC 1
Z9 1
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD DEC
PY 2008
VL 117
IS 12
BP 909
EP 913
PG 5
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 386AX
UT WOS:000261855800008
PM 19140537
ER

PT J
AU Kirtsreesakul, V
   Tuntaraworasin, J
   Thamjarungwong, B
AF Kirtsreesakul, Virat
   Tuntaraworasin, Jompon
   Thamjarungwong, Benjamas
TI Microbiology and Antimicrobial Susceptibility Patterns of Commensal
   Flora in the Middle Nasal Meatus
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE antimicrobial susceptibility; bacteriology; commensal flora; middle
   nasal meatus; nasal endoscopy
ID CHRONIC MAXILLARY SINUSITIS; COAGULASE-NEGATIVE STAPHYLOCOCCI; CHRONIC
   RHINOSINUSITIS; PARANASAL SINUSES; BACTERIOLOGY; CULTURES; METAANALYSIS;
   ASPIRATION; RESISTANCE; ADULTS
AB Objectives: We examined the microbiology and antimicrobial susceptibility patterns of commensal flora in the middle nasal meatus of normal subjects who were free of health care-associated risks and sinonasal disease.
   Methods: A prospective study was performed on 70 healthy volunteers without health care-associated risks or sinonasal disease. Middle meatal specimens were carefully taken by an endoscopically guided swab technique. The specimens were cultured for aerobic and anaerobic bacteria. Antimicrobial susceptibility testing was performed by the broth disc method.
   Results: Bacterial growths were recovered in 66 of the 70 specimens (94.3%). Coagulase-negative staphylococci (CNS) were the most common isolates (61.6%), followed by Staphylococcus aureus (11.6%) and Corynebacterium sp (9.3%). All growths were quantified as very rare (73.3%), rare (13.9%), or few (12.8%). Obligate anaerobic bacteria were not identified. The samples positive for CNS showed multiple resistances to antibiotics, including erythromycin stearate (30.2%), clindamycin hydrochloride (28.3%), oxacillin sodium (a clinical substitute for methicillin sodium; 18.9%), and sulfamethoxazole-trimethoprim (9.4%).
   Conclusions: A small amount of CNS with or without multiple antibiotic resistances and/or S aureus cultured from the middle meatus can be considered contaminants in middle meatal culture during an episode of rhinosinusitis.
C1 [Thamjarungwong, Benjamas] Prince Songkla Univ, Fac Med, Div Microbiol, Dept Pathol, Songkhla, Thailand.
   [Kirtsreesakul, Virat; Tuntaraworasin, Jompon] Prince Songkla Univ, Fac Med, Dept Otolaryngol, Div Allergy & Rhinol, Songkhla, Thailand.
RP Kirtsreesakul, V (reprint author), Prince Songkla Univ, Fac Med, Dept Otolaryngol, Div Allergy & Rhinol, Hat Yai 90110, Songkhla, Thailand.
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NR 30
TC 7
Z9 11
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD DEC
PY 2008
VL 117
IS 12
BP 914
EP 918
PG 5
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 386AX
UT WOS:000261855800009
PM 19140538
ER

PT J
AU Belafsky, PC
   Mouadeb, DA
   Rees, CJ
   Pryor, JC
   Postma, GN
   Allen, J
   Leonard, RJ
AF Belafsky, Peter C.
   Mouadeb, Debbie A.
   Rees, Catherine J.
   Pryor, Jan C.
   Postma, Gregory N.
   Allen, Jacqueline
   Leonard, Rebecca J.
TI Validity and Reliability of the Eating Assessment Tool (EAT-10)
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE data collection; dysphagia; outcome assessment; quality of life;
   questionnaire; survey; swallowing; SWAL-QOL
ID QUALITY-OF-LIFE; QOL OUTCOMES TOOL; SWAL-QOL; OROPHARYNGEAL DYSPHAGIA;
   NECK-CANCER; QUESTIONNAIRE; VALIDATION; ADULTS; PREVALENCE; STROKE
AB Objectives: The Eating Assessment Tool is a self-administered, symptom-specific outcome instrument for dysphagia. The purpose of this study was to assess the validity and reliability of the 10-item Eating Assessment Tool (EAT-10).
   Methods: The investigation consisted of 4 phases: 1) line-item generation, 2) line-item reduction and reliability, 3) normative data generation, and 4) validity analysis. All data were collected prospectively. Internal consistency was assessed with the Cronbach alpha. Test-retest reliability was evaluated with the Pearson product moment correlation coefficient. Normative data were obtained by administering the instrument to a community cohort of healthy volunteers. Validity was assessed by administering the instrument before and after dysphagia treatment and by evaluating survey differences between normal persons and those with known diagnoses.
   Results: A total of 629 surveys were administered to 482 patients. The internal consistency (Cronbach alpha) of the final instrument was 0.960. The test-retest intra-item correlation coefficients ranged from 0.72 to 0.91. The mean (+/- SD) EAT-10 score of the normal cohort was 0.40 +/- 1.01. The mean EAT-10 score was 23.58 +/- 13.18 for patients with esophageal dysphagia, 23.10 +/- 12.22 for those with oropharyngeal dysphagia, 9.19 +/- 12.60 for those with voice disorders, 22.42 +/- 14.06 for those with head and neck cancer, and 11.71 +/- 9.61 for those with reflux. The patients with oropharyngeal and esophageal dysphagia and a history of head and neck cancer had a significantly higher EAT-10 score than did those with reflux or voice disorders (p < 0.00 1). The mean EAT-10 score of the patients with dysphagia improved from 19.87 +/- 10.5 to 5.2 +/- 7.4 after treatment (p < 0.001).
   Conclusions: The EAT-10 has displayed excellent internal consistency, test-retest reproducibility, and criterion-based validity. The normative data suggest that an EAT-10 score of 3 or higher is abnormal. The instrument may be utilized to document the initial dysphagia severity and monitor the treatment response in persons with a wide array of swallowing disorders.
C1 [Belafsky, Peter C.; Mouadeb, Debbie A.; Rees, Catherine J.; Pryor, Jan C.; Allen, Jacqueline; Leonard, Rebecca J.] Univ Calif Davis, Dept Otolaryngol Head & Neck Surg, Ctr Voice & Swallowing, Sacramento, CA 95825 USA.
   [Postma, Gregory N.] Med Coll Georgia, Dept Otolaryngol Head & Neck Surg, Ctr Voice & Swallowing Disorders, Augusta, GA 30912 USA.
RP Belafsky, PC (reprint author), Univ Calif Davis, Dept Otolaryngol, Ctr Voice & Swallowing, 2521 Stockton Blvd,Suite 7200, Sacramento, CA 95825 USA.
CR ALEXANDER M, 2006, HEALTH QUAL LIFE OUT, V3, P67
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NR 23
TC 48
Z9 54
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD DEC
PY 2008
VL 117
IS 12
BP 919
EP 924
PG 6
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 386AX
UT WOS:000261855800010
PM 19140539
ER

PT J
AU Martinez-Alvernia, EA
   Mankarious, LA
AF Martinez-Alvernia, Efrain A.
   Mankarious, Leila A.
TI Matrix Metalloproteinases 2 and 9 Are Concentrated in the Luminal Aspect
   of the Cricoid Cartilage, Diminish With Loss of Perichondrium, and Are
   Reinstated by Transforming Growth Factor Beta 3
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE cricoid development; metalloproteinase; subglottic stenosis;
   transforming growth factor
AB Objectives: We determined the location of matrix metalloprotemases (MMP) 2 and 9, and whether the luminal perichondrium or transforming growth factor (TGF) beta 3 influences the presence of MMP-2 and/or -9 within the chondrocytes of the cricoid cartilage.
   Methods: Subglottises from 15 neonatal mice were divided into group A (N = 5; luminal epithelium intact, grown in basic medium), group B (N = 5; epithelium-free, with sections of luminal perichondrium removed, grown in basic medium), and group C (N = 5; epithelium-free, with sections of luminal perichondrium removed, grown in basic medium with supplemental TGF-beta 3). Immunohistochemical analysis was done to identify MMP-2 and -9 distributions.
   Results: Group A demonstrated concentrations of MMP-2 and -9 in the luminal perichondrial and adjacent chondrocytes with a gradual decrease in signal intensity toward the outer perichondrium. Group B showed findings similar to those in group A, but in the region of removed perichondrium, the adjacent chondrocytes lost MMP-2 and -9 signal. The group C rings demonstrated reestablishment of MMP-2 and -9 signal in regions of luminal perichondrial loss.
   Conclusions: Localization of MMP-2 and -9 is predominantly in the luminal perichondrium and gradually decreases toward the outer perichondrium. The luminal perichondrium maintains expression of MMP-2 and -9 within the adjacent chondrocytes. Exogenous TGF-beta 3 reestablishes production of at least MMP-9, and probably MMP-2, in cricoid cartilages missing luminal perichondrium.
C1 Massachusetts Eye & Ear Infirm, Dept Otolaryngol, Boston, MA 02114 USA.
   Harvard Univ, Sch Med, Boston, MA USA.
RP Mankarious, LA (reprint author), 243 Charles St, Boston, MA 02114 USA.
FU National Institutes of Health [KO8 HL070116]
FX Supported by National Institutes of Health grant KO8 HL070116. This
   study was performed in accordance with the PHS Policy on Humane Care and
   Use of Laboratory Animals, the NIH Guide for the Care and Use of
   Laboratory Animals, and the Animal Welfare Act (7 U.S.C. et seq.); the
   animal use protocol was approved by.the Institutional Animal Care and
   Use Committee (IACUC) of Massachusetts Eye and Ear Infirmary.
CR Alvarez J, 2001, DEV DYNAM, V221, P311, DOI 10.1002/dvdy.1141
   Malemud CJ, 2006, FRONT BIOSCI, V11, P1702, DOI 10.2741/1916
   Mankarious LA, 2006, OTOLARYNG HEAD NECK, V134, P843, DOI 10.1016/j.otohns.2005.12.023
   Martinez-Alvernia EA, 2008, OTOLARYNG HEAD NECK, V138, P435, DOI 10.1016/j.otohns.2007.11.009
   Nagase H, 2006, CARDIOVASC RES, V69, P562, DOI 10.1016/j.cardiores.2005.12.002
   Sternlicht MD, 2001, ANNU REV CELL DEV BI, V17, P463, DOI 10.1146/annurev.cellbio.17.1.463
NR 6
TC 3
Z9 5
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD DEC
PY 2008
VL 117
IS 12
BP 925
EP 930
PG 6
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 386AX
UT WOS:000261855800011
PM 19140540
ER

PT J
AU Han, JK
   Becker, SS
   Bomeli, SR
   Gross, CW
AF Han, Joseph K.
   Becker, Samuel S.
   Bomeli, Steven R.
   Gross, Charles W.
TI Endoscopic Localization of the Anterior and Posterior Ethmoid Arteries
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE complication; endoscopic sinus surgery; ethmoid artery; retrobulbar
   hematoma; skull base
ID INTRACTABLE EPISTAXIS; SINUS SURGERY; MANAGEMENT; LIGATION
AB Objectives: Understanding the endoscopic locations of the anterior and posterior ethmoid arteries is important during endoscopic sinus or endoscopic skull base procedures so that these arteries can be avoided. Therefore, the objective of this study was to define the endoscopic locations of the ethmoid arteries.
   Methods: Twenty-four cadaver heads were used to identify the endoscopic location of the ethmoid arteries via an external incision. An image guidance system was used to record the locations of these arteries. The anterior ethmoid artery was referenced to the axilla of the middle turbinate, and the posterior ethmoid artery to the anterior wall of the sphenoid sinus. The closest lamella to these arteries was identified.
   Results: Forty-eight nasal cavities were dissected. The mean distance from the axilla to the anterior ethmoid artery was 17.5 mm. The anterior ethmoid artery was located immediately anterior to (31%), at (36%), or immediately posterior to (33%) the superior attachment of the basal lamella. The mean distance from the posterior ethmoid artery to the anterior ethmoid artery was 14.9 mm. The mean distance from the posterior ethmoid artery to the anterior wall of the sphenoid sinus was 8.1 mm. The posterior ethmoid artery was either anterior to (98%) or at (2%) the anterior face of the sphenoid sinus.
   Conclusions: Specific endoscopic anatomic relationships and measurements have been presented for the anterior and posterior ethmoid arteries.
C1 [Han, Joseph K.] Eastern Virginia Med Sch, Div Rhinal & Endoscop Sinus & Skull Base Surg, Dept Otolaryngol Head & Neck Surg, Norfolk, VA 23507 USA.
   [Becker, Samuel S.; Bomeli, Steven R.; Gross, Charles W.] Univ Virginia Hlth Syst, Dept Otolaryngol Head & Neck Surg, Charlottesville, VA USA.
RP Han, JK (reprint author), Eastern Virginia Med Sch, Div Rhinal & Endoscop Sinus & Skull Base Surg, Dept Otolaryngol Head & Neck Surg, 825 Fairfax Ave,Suite 510, Norfolk, VA 23507 USA.
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NR 14
TC 7
Z9 8
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD DEC
PY 2008
VL 117
IS 12
BP 931
EP 935
PG 5
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 386AX
UT WOS:000261855800012
PM 19140541
ER

PT J
AU Hanley, PJ
   Davis, PB
   Paki, B
   Quinn, SA
   Bellekorn, SR
AF Hanley, Peter J.
   Davis, Paul B.
   Paki, Bardia
   Quinn, Shaunine A.
   Bellekorn, Sandra R.
TI Treatment of Tinnitus With a Customized, Dynamic Acoustic Neural
   Stimulus: Clinical Outcomes in General Private Practice
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE acoustic stimulation; cohort study; rehabilitation; tinnitus
ID MANAGEMENT; THERAPY; TRIAL
AB Objectives: We evaluate the relative effectiveness of a newly available tinnitus treatment approach for different categories of patients in general private, practice.
   Methods: This was a cohort study, sponsored by Neuromonics, involving the first 470 patients to undertake the Neuromonics Tinnitus Treatment in 1 Neuromonics tinnitus clinics. All patients were provided with a dynamic acoustic neural stimulus, customized to each patient's audiometric profile, for daily use as part of a structured rehabilitation program. Tinnitus disturbance was assessed before, during, and after treatment with the Tinnitus Reaction Questionnaire.
   Results: The outcomes displayed a relation with patients' suitability according to predefined criteria: among the most suitable patients (tier 1 cohort), 92% exceeded the threshold for success (defined as a reduction in tinnitus-related disturbance of at least 40%), and the mean improvement in tinnitus disturbance was 72%; the discontinuance rate was 4%. For other suitability categories, the success rates and mean improvements were somewhat lower, and the discontinuance rates higher (tier 2: 60%, 49%, and 16%, respectively; tier 3: 39%, 32%, and 17%, respectively).
   Conclusions: The results showed that the treatment is effective for suitable patients in the private practice setting, and they provide health-care professionals with guidance as to what patients might expect from treatment, depending on their degree of suitability.
C1 [Hanley, Peter J.; Davis, Paul B.; Paki, Bardia; Quinn, Shaunine A.; Bellekorn, Sandra R.] Neuromon Pty Ltd, Chatswood, NSW 2067, Australia.
RP Hanley, PJ (reprint author), Neuromon Pty Ltd, Level 2,12 Thomas St, Chatswood, NSW 2067, Australia.
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   Kaltenbach JA, 2006, HEARING RES, V216, P224, DOI 10.1016/j.heares.2006.01.002
   MARTINEZ DP, 2008, COGNITIVE B IN PRESS
   Newman CW, 1996, ARCH OTOLARYNGOL, V122, P143
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NR 22
TC 10
Z9 10
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD NOV
PY 2008
VL 117
IS 11
BP 791
EP 799
PG 9
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 374TO
UT WOS:000261066800001
PM 19102123
ER

PT J
AU Magliulo, G
   Parrotto, D
   Gagliardi, S
   Cuiuli, G
   Novello, C
AF Magliulo, Giuseppe
   Parrotto, Donato
   Gagliardi, Silvia
   Cuiuli, Giuseppe
   Novello, Concetta
TI Vestibular Evoked Periocular Potentials in Meniere's Disease After
   Glycerol Testing
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE endolymphatic hydrops; Meniere's disease; VEMP; VEPP; vestibular evoked
   potential
ID BONE-CONDUCTED SOUND; MYOGENIC POTENTIALS; ENDOLYMPHATIC HYDROPS;
   SACCULAR DYSFUNCTION; SCHWANNOMA SURGERY; STIMULATION
AB Objectives: The present investigation was specifically designed to evaluate the clinical application of vestibular evoked periocular potentials (VEPPs) in the diagnosis of endolymphatic hydrops.
   Methods: We compared the results of the traditional pure tone audiometry glycerol test with those of the vestibular evoked myogenic potential (VEMP) glycerol test and the VEPP glycerol test in 22 patients affected by unilateral endolymphatic hydrops.
   Results: Some patients had positive depletive tests with both VEMPs and VEPPs, and other patients had positive tests with either VEMPs or VEPPs.
   Conclusions: Our outcomes confirmed that vestibular evoked potentials represent a useful additional diagnostic tool in the diagnosis of endolymphatic hydrops. The role of VEPPs in this particular issue was not inferior to that of VEMPs. The outcomes also suggested that not only the saccule, but also the utriculus, may be involved in the genesis of VEPPs.
C1 [Magliulo, Giuseppe; Parrotto, Donato; Gagliardi, Silvia; Cuiuli, Giuseppe; Novello, Concetta] Univ Roma La Sapienza, Dept Otorhinolaryngol Audiol & Phoniatr G Ferreri, Rome, Italy.
RP Magliulo, G (reprint author), Via Gregorio VII 80, I-00165 Rome, Italy.
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   Shojaku H, 2001, ACTA OTO-LARYNGOL, P65
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   Todd NPM, 2007, CLIN NEUROPHYSIOL, V118, P381, DOI 10.1016/j.clinph.2006.09.025
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NR 28
TC 4
Z9 4
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD NOV
PY 2008
VL 117
IS 11
BP 800
EP 804
PG 5
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 374TO
UT WOS:000261066800002
PM 19102124
ER

PT J
AU de Wolf, MJF
   Hol, MKS
   Huygen, PLM
   Mylanus, EAM
   Cremers, CWRJ
AF de Wolf, Maarten J. F.
   Hol, Myrthe K. S.
   Huygen, Patrick L. M.
   Mylanus, Emmanuel A. M.
   Cremers, Cor W. R. J.
TI Nijmegen Results With Application of a Bone-Anchored Hearing Aid in
   Children: Simplified Surgical Technique
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE BAHA; bone-anchored hearing aid; child; fixture loss; hearing aid;
   osseointegration; skin reaction; syndromic indication
ID MODERATE MENTAL-RETARDATION; CONGENITAL AURAL ATRESIA; OSSEOINTEGRATED
   IMPLANTS; PERCUTANEOUS IMPLANTS; AUDIOMETRIC EVALUATION; YOUNG-CHILDREN;
   TEMPORAL BONE; BAHA SOFTBAND; EXPERIENCE; COMPLICATIONS
AB Objectives: A retrospective analysis was performed to evaluate the clinical outcome of percutaneous bone-anchored hearing aid (BAHA) application in children with the outcome measures of fixture loss and skin reactions.
   Methods: An analysis was done of 93 of the 101 children 16 years of age or younger who underwent the simplified Nijmegen surgical technique between January 1994 and July 2007.
   Results: Twenty-one of 129 fixtures (16.3%) were lost or removed. In 12 cases, osseointegration failed. The majority of the fixture losses (86%) occurred within 1 year after surgery. No differences were found between 3 age groups or between fixture lengths (seven 3-mm implants versus fourteen 4-mm implants). The BAHA fixtures were less stable in children than in adults. In 8 cases, Holgers grade 4 skin reactions were noted at an average (+/- SD) of 5.5 +/- 4.7 months after surgery, ie, significantly sooner than the milder reactions (p = 0.001). In 28 cases (22%), skin reactions of Holgers grades 2 to 4 were observed. Revision surgery to reduce subcutaneous scar tissue was necessary in 22 implants (17%).
   Conclusions: Fixture loss was more frequent in children than in adults. The age of the child and the length of the fixture did not appear to influence fixture stability. Children should undergo frequent checkups at the outpatient clinic.
C1 [de Wolf, Maarten J. F.; Hol, Myrthe K. S.; Huygen, Patrick L. M.; Mylanus, Emmanuel A. M.; Cremers, Cor W. R. J.] Radboud Univ Nijmegen, Med Ctr, Donders Ctr Neurosci, Dept Otorhinolaryngol, NL-6500 HB Nijmegen, Netherlands.
RP Cremers, CWRJ (reprint author), Radboud Univ Nijmegen, Med Ctr, Donders Ctr Neurosci, Dept Otorhinolaryngol, POB 9101, NL-6500 HB Nijmegen, Netherlands.
RI Mylanus, Emmanuel/D-2255-2010
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NR 39
TC 31
Z9 31
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD NOV
PY 2008
VL 117
IS 11
BP 805
EP 814
PG 10
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 374TO
UT WOS:000261066800003
PM 19102125
ER

PT J
AU Hamans, E
   Boudewyns, A
   Stuck, BA
   Baisch, A
   Willemen, M
   Verbraecken, J
   Van de Heyning, P
AF Hamans, Evert
   Boudewyns, An
   Stuck, Boris A.
   Baisch, Alexander
   Willemen, Marc
   Verbraecken, Johan
   Van de Heyning, Paul
TI Adjustable Tongue Advancement for Obstructive Sleep Apnea: A Pilot Study
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE hypopharynx; obstructive sleep apnea; sleep surgery; tongue base
ID TISSUE VOLUME REDUCTION; UVULOPALATOPHARYNGOPLASTY; ADULTS; AIRWAY
AB Objectives: Surgical treatment of obstructive sleep apnea (OSA) caused by hypopharyngeal collapse of the upper airway can be considered in patients who are intolerant to continuous positive airway pressure (CPAP). The present procedures addressing the hypopharynx are invasive and have substantial morbidity and limited efficacy.
   Methods: Ten patients (mean age, 44 years) with moderate to severe OSA, ie, an apnea-hypopnea index (AHI) between 15 and 50, with CPAP intolerance were included in a prospective, nonrandomized, multicenter study to evaluate the feasibility, safety, and efficacy of a novel tongue advancement procedure. The procedure consists of the implantation of a tissue anchor in the tongue base and an adjustment spool at the mandible. Titration of this tissue anchor results in advancement of the tongue and a patent upper airway.
   Results: The mean AHI decreased from 22.8 at baseline to 11.8 at the 6-month follow-up (p = 0.007). The Epworth Sleepiness Scale score decreased from 11.4 at baseline to 7.7 at the 6-month follow-up (p = 0.094), and the snoring score decreased from 7.5 at baseline to 3.9 at the 6-month follow-up (p = 0.005). Four technical adverse events were noted, and I clinical adverse event occurred.
   Conclusions: Adjustable tongue advancement is a feasible and relatively safe way to reduce the AHI and snoring in selected patients with moderate to severe OSA and CPAP intolerance. Technical improvements and refinements to the procedure are ongoing.
C1 [Hamans, Evert; Boudewyns, An; Van de Heyning, Paul] Univ Antwerp Hosp, Dept Otorhinolaryngol Head & Neck Surg, B-2650 Edegem, Belgium.
   [Willemen, Marc; Verbraecken, Johan] Univ Antwerp Hosp, Dept Chest Med, B-2650 Edegem, Belgium.
   [Stuck, Boris A.; Baisch, Alexander] Univ Hosp Mannheim, Dept Otorhinolaryngol Head & Neck Surg, Mannheim, Germany.
RP Hamans, E (reprint author), Univ Antwerp Hosp, Dept Otorhinolaryngol Head & Neck Surg, Wilrijk Str, B-2650 Edegem, Belgium.
EM evert.hamans@uza.be
CR Boudewyns A, 2000, ACTA OTO-LARYNGOL, V120, P981, DOI 10.1080/00016480050218735
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NR 17
TC 10
Z9 10
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD NOV
PY 2008
VL 117
IS 11
BP 815
EP 823
PG 9
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 374TO
UT WOS:000261066800004
PM 19102126
ER

PT J
AU Tanna, N
   Sidell, D
   Schwartz, AM
   Schessel, DA
AF Tanna, Neil
   Sidell, Douglas
   Schwartz, Amold M.
   Schessel, David A.
TI Cystic Lymphatic Malformation of the Middle Ear
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE lymphangioma; lymphatic malformation; middle ear
ID NECK
AB Objectives: We review the clinical, radiologic, and histopathologic features of cystic lymphangioma of the middle ear, and discuss the developmental etiology and management of such a lesion.
   Methods: We present an unusual location for the development of a cystic lymphangioma with emphasis on etiology, clinical implications, and current treatment.
   Results: A 10-year-old girl presented with a mass involving the medial surface of the right tympanic membrane. T2-weighted magnetic resonance imaging demonstrated a hyperintense lesion in the anterior-superior middle ear cavity without out evidence of vascular abnormalities.
   Conclusions: To our knowledge, this is the only report of lymphangioma involving the middle ear represented in the English-language literature. Such a lesion has been demonstrated to arise from abnormalities in growth factors that contribute to the tightly regulated process of lymphangiogenesis. Lymphatic malformations can be diagnosed presumptively by virtue of magnetic resonance imaging in combination with a detailed physical examination. The treatment of choice for lymphangiomas located in the middle ear is surgical excision. Definitive diagnosis of the lesion is then made by identifying specific histopathologic characteristics. Although rare and histologically benign, middle ear lymphangiomas may produce significant patient discomfort and ultimately a conductive hearing loss. Therefore, these lesions warrant early recognition and treatment.
C1 [Tanna, Neil; Schessel, David A.] George Washington Univ, Div Otolaryngol Head & Neck Surg, Washington, DC 20037 USA.
   [Schwartz, Amold M.] George Washington Univ, Dept Pathol, Washington, DC 20037 USA.
   [Schessel, David A.] George Washington Univ, Dept Otolaryngol, Childrens Natl Med Ctr, Washington, DC 20037 USA.
   [Sidell, Douglas] Univ Calif Los Angeles, David Geffen Sch Med, Div Head & Neck Surg, Los Angeles, CA 90095 USA.
RP Schessel, DA (reprint author), George Washington Univ, Div Otolaryngol Head & Neck Surg, 2150 Penn Ave NW, Washington, DC 20037 USA.
CR Christison-Lagay ER, 2006, SURG CLIN N AM, V86, P393, DOI 10.1016/j.suc.2005.12.017
   Giguere CM, 2002, ANN OTO RHINOL LARYN, V111, P1066
   Gross E, 2006, SURG CLIN N AM, V86, P383, DOI 10.1016/j.suc.2005.12.013
   Kennedy TL, 2001, LARYNGOSCOPE, V111, P1929, DOI 10.1097/00005537-200111000-00011
   Naidu SI, 2004, ANN OTO RHINOL LARYN, V113, P218
   Riechelmann H, 1999, ARCH OTOLARYNGOL, V125, P643
   Sabin FR, 1902, AM J ANAT, V1, P367, DOI 10.1002/aja.1000010310
   Thompson Lester, 2006, Ear Nose Throat J, V85, P18
NR 8
TC 1
Z9 1
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD NOV
PY 2008
VL 117
IS 11
BP 824
EP 826
PG 3
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 374TO
UT WOS:000261066800005
PM 19102127
ER

PT J
AU Cosetti, M
   Culang, D
   Kotla, S
   O'Brien, P
   Eberl, DF
   Hannan, F
AF Cosetti, Maura
   Culang, David
   Kotla, Sumankrishna
   O'Brien, Peter
   Eberl, Daniel F.
   Hannan, Frances
TI Unique Transgenic Animal Model for Hereditary Hearing Loss
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE auditory evoked response; deafness mutant; Drosophila; microfilament
   protein; tetraspan membrane protein
ID HAIR-CELL DIFFERENTIATION; CHICK INNER-EAR; DROSOPHILA-MELANOGASTER;
   PROSENSORY PATCHES; GENE; TRANSDUCTION; DEAFNESS; MECHANISMS; MUTATION;
   ORGAN
AB Objectives: This study capitalizes on the unique molecular and developmental similarities between the auditory organs of Drosophila and mammals, to investigate genes implicated in human syndromic and nonsyndromic hearing loss in a genetically tractable experimental animal model, the fruit fly Drosophila.
   Methods: The Drosophila counterparts of 3 human deafness genes (DIAPH1/DFNA1, ESPN/DFNB36, and TMHS/DFNB67) were identified by sequence similarity. An electrophysiological assay was used to record sound-evoked potentials in response to an acoustic stimulus, the Drosophila courtship song.
   Results: Flies with mutations affecting the diaphanous, forked, and CG12026/TMHS genes displayed significant reductions in the amplitude of sound-evoked potentials compared to wild-type flies (p < 0.05 to p < 0.005). The mean responses were reduced from approximately 500 to 600 mu V in wild-type flies to approximately 100 to 300 RV in most mutant flies.
   Conclusions: The identification of significant auditory dysfunction in Drosophila orthologs of human deafness genes will facilitate exploration of the molecular biochemistry of auditory mechanosensation. This may eventually allow for novel diagnostic and therapeutic approaches to human hereditary hearing loss.
C1 [Kotla, Sumankrishna; O'Brien, Peter; Hannan, Frances] New York Med Coll, Dept Cell Biol & Anat, Valhalla, NY 10595 USA.
   [Kotla, Sumankrishna; O'Brien, Peter; Hannan, Frances] New York Med Coll, Dept Otolaryngol, Valhalla, NY 10595 USA.
   [Cosetti, Maura; Culang, David] New York Eye & Ear Infirm, Dept Otolaryngol, New York, NY 10003 USA.
   [Eberl, Daniel F.] Univ Iowa, Dept Biol, Iowa City, IA 52242 USA.
RP Hannan, F (reprint author), New York Med Coll, Dept Cell Biol & Anat, Basic Sci Bldg,15 Dana Rd, Valhalla, NY 10595 USA.
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NR 32
TC 2
Z9 2
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD NOV
PY 2008
VL 117
IS 11
BP 827
EP 833
PG 7
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 374TO
UT WOS:000261066800006
PM 19102128
ER

PT J
AU Wormald, RN
   Moran, RJ
   Reilly, RB
   Lacy, PD
AF Wormald, Robert N.
   Moran, Rosalyn J.
   Reilly, Richard B.
   Lacy, Peter D.
TI Performance of an Automated, Remote System to Detect Vocal Fold
   Paralysis
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE phonation; speech; telemedicine; voice
AB Objectives: The aim of this project was to evaluate the diagnostic accuracy of an automated, remote system for correctly identifying vocal fold paralysis.
   Methods: Consecutive patients presenting for vocal analysis at the Beaumont Hospital Voice Clinic were enrolled in this prospective, blinded study. Control patients were enlisted from routine otolaryngology clinics. All patients were assessed by standard history, clinical examination, and flexible laryngoscopy or videostroboscopy. The subjects were blindly assessed by remote voice analysis. Sustained phonation was recorded over a standard telephone network. Each recording was subjected to automated, remote analysis of extracted features, including measures of pitch perturbation, amplitude perturbation, and harmonics-to-noise ratio. The presence or absence of a vocal fold paralysis as determined by the automated classifier was recorded and correlated with clinical findings.
   Results: Seventy-eight consecutive patients were enrolled in the study. The automated speech analysis system demonstrated 92% sensitivity and 75% specificity for detecting vocal fold paralysis.
   Conclusions: This pilot study, assessing an automated system that analyzes audiological data remotely over the standard telephone network, suggests that with further "training" it may become a reliable, simple, and convenient means for screening patients for voice disorders.
C1 [Wormald, Robert N.; Lacy, Peter D.] Univ Coll Dublin, Beaumont Hosp, Dept Otolaryngol Head & Neck Surg, Dublin 2, Ireland.
   [Moran, Rosalyn J.; Reilly, Richard B.] Univ Coll Dublin, Sch Elect Elect & Mech Engn, Dublin 2, Ireland.
RP Wormald, RN (reprint author), 1 Laurelwood,Douglas Rd, Cork, Ireland.
RI Reilly, Richard/F-7034-2011
OI Reilly, Richard/0000-0001-8578-1245
CR BECKER W, 1994, EAR NOSE THROAT DISO
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NR 12
TC 5
Z9 5
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD NOV
PY 2008
VL 117
IS 11
BP 834
EP 838
PG 5
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 374TO
UT WOS:000261066800007
PM 19102129
ER

PT J
AU Kadmon, G
   Stern, Y
   Bron-Harlev, E
   Nahum, E
   Battat, E
   Schonfeld, T
AF Kadmon, Gili
   Stern, Yoram
   Bron-Harlev, Efrat
   Nahum, Elhanan
   Battat, Erez
   Schonfeld, Tommy
TI Computerized Scoring System for the Diagnosis of Foreign Body Aspiration
   in Children
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE algorithm; aspiration; child; computer; foreign body; probability
ID BRONCHOSCOPY; BODIES; RADIOGRAPHY; EXPERIENCE; MANAGEMENT; UTILITY
AB Objectives: Foreign body aspiration (FBA) is a life-threatening event in children. The gold standard for diagnosis is bronchoscopy, but there is no consensus regarding indications for the procedure. The aim of this study was to formulate a predictive model for assessing the probability of FBA in suspected cases as an aid in the decision to perform diagnostic bronchoscopy.
   Methods: The files of 150 patients who underwent bronchoscopy for suspected FBA at our center between 1996 and 2004 were reviewed for medical history, physical examination, and radiologic studies. The findings were analyzed by logistic regression.
   Results: Using the file data, we formulated a predictive model wherein each parameter received a numeric coefficient representing its significance in evaluating suspected FBA. The most significant parameters were age 10 to 24 months, foreign body in the child's mouth and severe respiratory complaints during the choking episode, hypoxemia, dyspnea or stridor following the acute event, unilateral signs on lung auscultation, abnormal tracheal radiogram, unilateral infiltrate or atelectasis, and local hyperinflation or obstructive emphysema on chest radiogram.
   Conclusions: In our predictive model, every case of suspected FBA can be assigned a score based on the specific parameters present, which is then entered into a probability formula to determine the likelihood of a positive diagnosis. This model may serve as a useful tool for deciding on the use of bronchoscopy in all children with suspected FBA.
C1 [Stern, Yoram] Schneider Childrens Med Ctr Israel, Pediat Otolaryngol Clin, IL-49202 Petah Tiqwa, Israel.
   [Kadmon, Gili; Bron-Harlev, Efrat; Nahum, Elhanan; Schonfeld, Tommy] Schneider Childrens Med Ctr Israel, Pediat Intens Care Unit, IL-49202 Petah Tiqwa, Israel.
   [Stern, Yoram] Tel Aviv Univ, Sackler Fac Med, IL-69978 Tel Aviv, Israel.
   [Battat, Erez] Clalit Hlth Serv, Tel Aviv, Israel.
RP Stern, Y (reprint author), Schneider Childrens Med Ctr Israel, Pediat Otolaryngol Clin, IL-49202 Petah Tiqwa, Israel.
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NR 21
TC 11
Z9 11
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD NOV
PY 2008
VL 117
IS 11
BP 839
EP 843
PG 5
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 374TO
UT WOS:000261066800008
PM 19102130
ER

PT J
AU Wang, JH
   Lee, BJ
   Lee, JH
   Kim, IJ
   Jang, YJ
AF Wang, Jong Hwan
   Lee, Bong-Jae
   Lee, Jeong Hyun
   Kim, In June
   Jang, Yong Ju
TI Development of Mucosal Thickening After Radiotherapy in Contralateral
   Sinuses of Patients With Nasal Cavity and/or Paranasal Sinus Carcinoma
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE carcinoma; computed tomography; Lund-Mackay staging system; mucosal
   thickening; paranasal sinus; radiotherapy
ID NASOPHARYNGEAL CARCINOMA; CHRONIC RHINOSINUSITIS; MAXILLARY SINUS;
   DIAGNOSIS; THERAPY
AB Objectives: The aim of this study was to investigate the development of radiotherapy (RT)-induced mucosal thickening (MT) of the contralateral sinuses in patients with nasal cavity and/or paranasal sinus carcinoma.
   Methods: We retrospectively reviewed the medical records and the initial and follow-up computed tomography (CT) scans of 37 patients with RT and 10 controls without RT. The CT scans were scored on the Lund-Mackay (LM) staging system.
   Results: Fifteen of the 37 patients had MT before RT, and the mean LM score was 0.68. The MT incidence significantly increased, to 72.9% (p = 0.009), and the LM score significantly increased, to 2.84 (p < 0.001), by 3 months after RT, after which the LM score decreased gradually to 1.73 at 36 months after RT. Four of the 10 controls had MT before treatment, and their mean LM score was 0.7. Their MT incidence and LM score had not changed significantly at 3 months after treatment. The pretreatment LM scores of the patient group and the control group were not significantly different, but their posttreatment LM scores were significantly different at the 3-month follow-up (p = 0.033).
   Conclusions: Use of RT in patients with nasal cavit and/or paranasal sinus carcinoma may cause a significant increase in the incidence of MT and in the LM scores in all sites of the paranasal sinuses by 3 months after RT, after which the LM score decreases gradually.
C1 [Wang, Jong Hwan; Lee, Bong-Jae; Kim, In June; Jang, Yong Ju] Univ Ulsan, Coll Med, Asan Med Ctr, Dept Otolaryngol, Seoul 138736, South Korea.
   [Lee, Jeong Hyun] Univ Ulsan, Coll Med, Asan Med Ctr, Dept Radiol, Seoul 138736, South Korea.
RP Jang, YJ (reprint author), Univ Ulsan, Coll Med, Asan Med Ctr, Dept Otolaryngol, 388-1 Pungnap 2 Dong, Seoul 138736, South Korea.
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NR 16
TC 1
Z9 1
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD NOV
PY 2008
VL 117
IS 11
BP 844
EP 848
PG 5
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 374TO
UT WOS:000261066800009
PM 19102131
ER

PT J
AU Suzuki, M
   Saigusa, H
   Kurogi, R
   Morita, S
   Ishizuka, Y
AF Suzuki, Masaaki
   Saigusa, Hanako
   Kurogi, Ryoko
   Morita, Shigeho
   Ishizuka, Yoichi
TI Postoperative Monitoring of Esophageal Pressure in Patients With
   Obstructive Sleep Apnea-Hypopnea Syndrome Who Have Undergone
   Tonsillectomy With Uvulopalatopharyngoplasty
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE esophageal pressure; obstructive sleep apnea-hypopnea syndrome;
   postoperative monitoring; sleep-disordered breathing; tonsillectomy;
   uvulopalatopharyngoplasty
AB Objectives: To realize better postoperative management in patients with obstructive sleep apnea-hypopnea syndrome (OSAHS), we elucidated the need for the postoperative monitoring of esophageal pressure (Pes).
   Methods: A prospective randomized controlled study was per-formed. Adult patients with OSAHS were divided into 2 groups: those administered autoadjusted continuous positive airway pressure (CPAP) before, on, and after the first postoperative night (CPAP group) and those not administered CPAP before or after the surgery (non-CPAP group). Tonsillectomy with uvulopalatopharyngoplasty (UPPP) under general anesthesia was performed on all of the patients. On the first postoperative night, continuous overnight monitoring of Pes and oxygen saturation level was carried out simultaneously with oxygen supplementation in both groups in the patient's room in the general ward.
   Results: The CPAP group showed a significantly improved mean inspiratory maximal end-apneic Pes swing on the first postoperative night as compared with the non-CPAP group, although there was no significant difference in oxygen desaturation index on the first postoperative night between the 2 groups.
   Conclusions: Continuous Pes monitoring and CPAP administration were beneficial in the detection and minimization of respiratory disturbances in patients with OSAHS who underwent tonsillectomy with UPPP under general anesthesia.
C1 [Suzuki, Masaaki; Saigusa, Hanako; Kurogi, Ryoko; Morita, Shigeho; Ishizuka, Yoichi] Teikyo Univ, Sch Med, Dept Otolaryngol, Itabashi Ku, Tokyo 1738605, Japan.
RP Suzuki, M (reprint author), Teikyo Univ, Sch Med, Dept Otolaryngol, Itabashi Ku, 2-11-1 Kaga, Tokyo 1738605, Japan.
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NR 16
TC 0
Z9 1
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD NOV
PY 2008
VL 117
IS 11
BP 849
EP 853
PG 5
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 374TO
UT WOS:000261066800010
PM 19102132
ER

PT J
AU Schroeder, U
   Dietlein, M
   Wittekindt, C
   Ortmann, M
   Stuetzer, H
   Vent, J
   Jungehuelsing, M
   Krug, B
AF Schroeder, Ursula
   Dietlein, Markus
   Wittekindt, Claus
   Ortmann, Monika
   Stuetzer, Hartmut
   Vent, Julia
   Jungehuelsing, Markus
   Krug, Barbara
TI Is There a Need for Positron Emission Tomography Imaging to Stage the N0
   Neck in T1-T2 Squamous Cell Carcinoma of the Oral Cavity or Oropharynx?
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE elective neck dissection; fluorodeoxyglucose positron emission
   tomography; head and neck squamous cell carcinoma; imaging; occult
   metastasis
ID LYMPH-NODE METASTASES; CLINICALLY NEGATIVE NECK; FDG-PET; DISSECTION
   SPECIMENS; COMPUTED-TOMOGRAPHY; F-18-FDG PET; CANCER; HEAD; MRI; CT
AB Objectives: We assess whether negative findings on computed tomography (CT), magnetic resonance imaging (MRI), and/or F-18-fluorodeoxyglucose positron emission tomography ((18)FDG-PET) may contribute to the decision-making process of elective neck dissection (eND) in patients with squamous cell carcinoma of the oral cavity or the oropharynx (oSCC) staged cT1-T2 cN0 cM0.
   Methods: We interpreted CT, MRI, and (18)FDG-PET images separately, after combining the data of CT with those of (18)FDG-PET and the data of MRI with those of (18)FDG-PET. Each set of results was then compared with the histopathologic results of ipsilateral or bilateral eND in a prospective, blinded study.
   Results: The histopathologic examination of 594 lymph nodes revealed 4 metastases less than 4 mm in diameter and 3 micrometastases (less than 2 mm) in 6 of 17 patients. On CT, MRI, and (18)FDG-PET, respectively, 5, 5, and 0 cases were true-malignant (true positives) and 4, 10, and 1 cases were false-malignant (false positives). The accuracy was not enhanced by fusing CT with (18)FDG-PET or MRI with 18FDG-PET.
   Conclusions: The delectability threshold of occult metastases appears to be below the spatial and contrast resolution of CT, MRI, and 18FDG-PET. The decision for eND in patients with cT1-T2 cN0 cM0 oSCC cannot be based upon cross-sectional imaging at the resolutions currently available.
C1 [Schroeder, Ursula; Wittekindt, Claus; Vent, Julia] Univ Cologne, Med Ctr, Dept Otolaryngol Head & Neck Surg, Cologne, Germany.
   [Dietlein, Markus] Univ Cologne, Med Ctr, Dept Nucl Med, Cologne, Germany.
   [Ortmann, Monika] Univ Cologne, Med Ctr, Inst Pathol, Cologne, Germany.
   [Stuetzer, Hartmut] Univ Cologne, Med Ctr, Inst Med Stat Informat & Epidemiol, Cologne, Germany.
   [Krug, Barbara] Univ Cologne, Med Ctr, Dept Radiol, Cologne, Germany.
   [Jungehuelsing, Markus] Klinikum Ernst Von Bergmann, Dept Otolaryngol Head & Neck Surg, Potsdam, Germany.
RP Schroeder, U (reprint author), Univ Schleswig Holstein, Dept Otorhinolaryngol Head & Neck Surg, Campus Lubeck,Ratzeburger Allee 160, D-23568 Lubeck, Germany.
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NR 28
TC 10
Z9 11
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD NOV
PY 2008
VL 117
IS 11
BP 854
EP 863
PG 10
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 374TO
UT WOS:000261066800011
PM 19102133
ER

PT J
AU Wiley, S
   Meinzen-Derr, J
   Choo, D
AF Wiley, Susan
   Meinzen-Derr, Jareen
   Choo, Daniel
TI Auditory Skills Development Among Children With Developmental Delays and
   Cochlear Implants
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE developmental delay; pediatric cochlear implantation
ID INTENSIVE BEHAVIORAL TREATMENT; HANDICAPPED-CHILDREN;
   LANGUAGE-DEVELOPMENT; EARLY-CHILDHOOD; AUTISM; DISABILITY; OUTCOMES;
   SPEECH
AB Objectives: We sought to understand auditory skills outcomes in young children with cochlear implants and developmental delay.
   Methods: Children who received cochlear implants at less than 36 months of age were identified via chart review. Their postimplant auditory skills outcomes were measured with the Auditory Skills Checklist.
   Results: Of 35 children who received cochlear implants before the age of 36 months, 14 children (40%) had additional disabilities or some form of developmental delay. The 12-month postimplant data indicated progress in all groups of children. Children with additional disabilities had the same rate of auditory skills progress as children with no additional disabilities (beta = 9.3 versus 9.3; p = 0.5). However, the children with additional disabilities tended to start at a lower baseline skills set (approximately 6 points lower) on the Auditory Skills Checklist. For children with average developmental quotients (at least 80), the rate of progress was twice that of children with a developmental quotient of less than 80, irrespective of a developmental disability (beta = 9.9 versus 4.8; p = 0.03). Children with a developmental quotient of less than 80 were less likely to gain skills in discrimination and identification after the first postimplant year.
   Conclusions: Children with additional disabilities make progress in auditory skills, but may not develop higher auditory skills of identification and comprehension within the first 6 months after implantation. Categorizing children according to a cognitive developmental quotient may provide more predictive ability than does categorizing them by disability type.
C1 [Wiley, Susan] Univ Cincinnati, Coll Med, Div Dev & Behav Pediat, Cincinnati, OH USA.
   [Meinzen-Derr, Jareen] Univ Cincinnati, Coll Med, Ctr Biostat & Epidemiol, Cincinnati, OH USA.
   [Meinzen-Derr, Jareen; Choo, Daniel] Univ Cincinnati, Coll Med, Div Pediat Otolaryngol, Ear & Hearing Ctr, Cincinnati, OH USA.
   [Meinzen-Derr, Jareen; Choo, Daniel] Univ Cincinnati, Coll Med, Dept Otolaryngol, Cincinnati, OH USA.
RP Wiley, S (reprint author), Cincinnati Childrens Hosp, Med Ctr, 3333 Burnet Ave,ML 4002, Cincinnati, OH 45229 USA.
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NR 33
TC 17
Z9 17
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD OCT
PY 2008
VL 117
IS 10
BP 711
EP 718
PG 8
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 365WS
UT WOS:000260440800001
PM 18998496
ER

PT J
AU Haginomori, S
   Nonaka, R
   Takenaka, H
   Ueda, K
AF Haginomori, Shin-Ichi
   Nonaka, Ryuzaburo
   Takenaka, Hiroshi
   Ueda, Koichi
TI Canal Wall-Down Tympanoplasty With Soft-Wall Reconstruction Using the
   Pedicled Temporoparietal Fascial Flap: Technique and Preliminary Results
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE blood supply; canal wall-down tympanoplasty; epithelialization;
   soft-wall reconstruction; superficial temporal artery; temporoparietal
   fascial flap
ID MASTOID OBLITERATION; CHOLESTEATOMA SURGERY; MIDDLE-EAR; MYRINGOPLASTY
AB Objectives: We compared the use of the pedicled temporoparietal fascial flap (TPFF) with the use of free deep temporal fascia (DTF) in soft-wall reconstruction after canal wall-down tympanoplasty.
   Methods: In the TPFF group (6 ears), the pedicled TPFF that includes the superficial temporal artery and vein was raised ipsilaterally and rotated into the eradicated mastoid cavity. The tympanic membrane and external auditory canal (EAC) were reconstructed by gluing one side of the TPFF to the mucosal layer of the tympanic membrane and the reverse side of the posterior EAC skin. In the DTF group (21 ears), reconstruction was performed similarly with free DTF. The postoperative period for epithelialization of the tympanic membrane and EAC skin, postoperative complications, and reaeration in the middle ear revealed by computed tomography were reviewed in both groups.
   Results: In the TPFF group, the mean ( +/- SD) period to epithelialization was 25.5 +/- 2.8 days versus 38.4 +/- 12.0 days in the DTF group; the two groups differed statistically (Welch's t-test, p = 0.0002). No postoperative complications occurred in the TPFF group, whereas 2 patients in the DTF group underwent graft necrosis with infection. Three of the 6 patients in the TPFF group showed reaeration not only in the tympanic cavity, but also in the mastoid cavity. However, no statistical differences between the two groups were observed in terms of postoperative complications or reaeration of the mastoid cavity.
   Conclusions: Our preliminary findings suggest that the pedicled TPFF has positive effects on quick epithelialization. Further prospective studies are needed to reveal the superiority of the pedicled TPFF over free DTF with regard to postoperative infection and recovery of mastoid aeration.
C1 [Haginomori, Shin-Ichi; Nonaka, Ryuzaburo; Takenaka, Hiroshi] Osaka Med Coll, Dept Otolaryngol, Takatsuki, Osaka 5698686, Japan.
   [Ueda, Koichi] Osaka Med Coll, Dept Plast & Reconstruct Surg, Takatsuki, Osaka 5698686, Japan.
RP Haginomori, S (reprint author), Osaka Med Coll, Dept Otolaryngol, 2-7 Daigakumachi, Takatsuki, Osaka 5698686, Japan.
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NR 34
TC 4
Z9 4
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD OCT
PY 2008
VL 117
IS 10
BP 719
EP 726
PG 8
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 365WS
UT WOS:000260440800002
PM 18998497
ER

PT J
AU Brook, I
   Gober, AE
AF Brook, Itzhak
   Gober, Alan E.
TI Recovery of Potential Pathogens in the Nasopharynx of Healthy and Otitis
   Media-Prone Children and Their Smoking and Nonsmoking Parents
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE Haemophilus influenzae; Moraxella catarrhalis; otitis media; smoking;
   Streptococcus pneumoniae
ID INTERFERING BACTERIA; ADHERENCE; SMOKERS
AB Objectives: Exposure to smoking is associated with colonization with pathogenic bacteria. This study investigated the frequency of isolation of potential pathogens in the nasopharynx of healthy and otitis media-prone (OMP) children and their smoking or nonsmoking parents.
   Methods: Posterior nasopharynx cultures were taken from 40 healthy and 40 OMP children and one of their parents. Twenty parents in each group were smokers. Potential pathogenic organisms were identified.
   Results: In the healthy children whose parents smoked, 15 potential pathogens were isolated from the parents and 13 were recovered from their children. Among the healthy children whose parents were nonsmokers, 3 potential pathogens were isolated from 2 parents (p < 0.005, compared to the parents and children in the smoking group) and 7 were recovered from their children. In the OMP children whose parents smoked, 16 potential pathogens were isolated from the parents and 19 were found in their children. Among the OMP children with nonsmoking parents, 3 potential pathogens were isolated from the parents (p < 0.001, compared to the parents and children in the OMP smoking group and the healthy children in the nonsmoking parents group) and 17 were recovered from their children.
   Conclusions: Parents who smoke are more often colonized with pathogens than those who do not smoke. The nasopharynx of healthy children of smokers harbors a high number of pathogens that are similar to the flora found in their parents and OMP children. Pathogenic organisms were found more often in OMP children of both smoking and nonsmoking parents, as compared to healthy children whose parents were nonsmokers. Concordance with pathogens in the parent was high among the OMP children of smoking parents, but this was not observed in the OMP children of nonsmokers.
C1 [Brook, Itzhak; Gober, Alan E.] Georgetown Univ, Sch Med, Dept Pediat, Washington, DC 20007 USA.
RP Brook, I (reprint author), 4431 Albemarle St NW, Washington, DC 20016 USA.
CR ARONSON MD, 1982, JAMA-J AM MED ASSOC, V248, P181, DOI 10.1001/jama.248.2.181
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   Brook I, 2005, CHEST, V127, P2072, DOI 10.1378/chest.127.6.2072
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NR 11
TC 15
Z9 18
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD OCT
PY 2008
VL 117
IS 10
BP 727
EP 730
PG 4
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 365WS
UT WOS:000260440800003
PM 18998498
ER

PT J
AU Alexander, RE
   Silber, J
   Myssiorek, D
AF Alexander, Ronda E.
   Silber, Jeffrey
   Myssiorek, David
TI Staged Surgical Management of Hypopharyngeal Traction Diverticulum
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT 88th Annual Meeting of the American-Broncho-Esophagological-Association
CY MAY 01-02, 2008
CL Orlando, FL
SP Amer Broncho Esophagol Assoc
DE pharyngeal diverticulum; spine complications
ID ZENKER DIVERTICULUM; COMPLICATIONS; FUSION
AB A 50-year-old woman who had undergone cervical spine fixation 6 years earlier presented with dysphagia, regurgitation of undigested food, halitosis, and weight loss. Operative examination demonstrated a hypopharyngeal diverticulum with spinal hardware visible in a defect in the mucosa. She underwent an open cervical approach to removal of the hardware. Endoscopic staple diverticulotomy as described by Scher and Richtsmeier was performed 8 weeks later in the ambulatory surgical setting. After a period of enteral feeding via a nasogastric tube in the initial postoperative period, she was able to resume oral nutrition in the interim between the surgical procedures. After the second procedure, she was able to resume a normal diet immediately and she experienced minimal symptoms. It is established that traction diverticulum is appropriately treated by removing the inciting anatomic factor(s). We propose that staged surgical management begin with the removal of the nidus followed by marsupialization of the diverticulum pouch. Standard staple diverticulotomy is a viable option for the second stage. This technique allows the patient to minimize the length of, or avoid, the second hospitalization for diverticulum management.
C1 [Alexander, Ronda E.] New York Ctr Voice & Swallowing Disorders, Dept Laryngol, New York, NY USA.
   [Alexander, Ronda E.] St Lukes Roosevelt Hosp, Dept Otolaryngol, New York, NY USA.
   [Myssiorek, David] NYU, Med Ctr, Dept Otolaryngol, New York, NY 10016 USA.
   [Silber, Jeffrey] Long Isl Jewish Med Ctr, Dept Orthoped Surg, New Hyde Pk, NY 11042 USA.
RP Myssiorek, D (reprint author), NYU, Ctr Clin Canc, Dept Otolaryngol, 9th Floor,160 E 34th St, New York, NY 10016 USA.
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   Fountas KN, 2007, SPINE, V32, P2310
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   Kaman Lileswar, 2003, Indian J Gastroenterol, V22, P65
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   RAZIEL A, 2000, DIS ESOPHAGUS, V13, P17
   Scher RL, 1996, LARYNGOSCOPE, V106, P951, DOI 10.1097/00005537-199608000-00007
   Smith SR, 2002, ARCH OTOLARYNGOL, V128, P141
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NR 10
TC 0
Z9 0
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD OCT
PY 2008
VL 117
IS 10
BP 731
EP 733
PG 3
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 365WS
UT WOS:000260440800004
PM 18998499
ER

PT J
AU Sato, K
   Nakashima, T
AF Sato, Kiminori
   Nakashima, Tadashi
TI Effect of Irradiation on the Human Laryngeal Glands
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE irradiation; laryngeal gland; larynx; local immunity; lubrication
ID RADIOTHERAPY
AB Objectives: The present study was conducted to determine the effects of irradiation on the human laryngeal glands.
   Methods: Light and transmission electron microscopic observations were made.
   Results: Granular endoplasmic reticula and Golgi apparatuses were sparse in the cytoplasm of serous and mucous cells in cases with a short duration after radiotherapy. The secretory granules in serous cells had decreased in number. The secretory granules were less electron-dense compared to those in non-irradiated specimens, but were electron-lucent. The mucigen droplets in mucous cells were not as numerous as those in non-irradiated specimens. The discharge of secretory granules and mucigen droplets had decreased. In cases with a long duration after radiotherapy, there were some granular endoplasmic reticula and Golgi apparatuses in the cytoplasm. However, the transmission electron microscopy findings of secretory granules and mucigen droplets were the same as those in the irradiated glands with a short duration after radiotherapy.
   Conclusions: Morphological changes in the irradiated laryngeal glands influenced not only the amount but also the quality of secretions. The above changes lessened the lubrication of the vocal folds, thus causing a voice disorder to some extent. Local immunity and mucociliary transport were also affected. The effects of irradiation on the laryngeal glands partially altered the laryngeal functions.
C1 [Sato, Kiminori; Nakashima, Tadashi] Kurume Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, Kurume, Fukuoka 8300011, Japan.
RP Sato, K (reprint author), Kurume Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, 67 Asahi Machi, Kurume, Fukuoka 8300011, Japan.
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   SATO K, AM J OTOLAR IN PRESS
NR 14
TC 3
Z9 3
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD OCT
PY 2008
VL 117
IS 10
BP 734
EP 739
PG 6
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 365WS
UT WOS:000260440800005
PM 18998500
ER

PT J
AU Linday, LA
   Shindledecker, RD
   Dolitsky, JN
   Chen, TC
   Holick, MF
AF Linday, Linda A.
   Shindledecker, Richard D.
   Dolitsky, Jay N.
   Chen, Tai C.
   Holick, Michael F.
TI Plasma 25-Hydroxyvitamin D Levels in Young Children Undergoing Placement
   of Tympanostomy Tubes
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT 5th International Symposium on Pediatric Infectious Diseases in Ears,
   Nose and Throat
CY OCT 19-21, 2007
CL Sao Paulo, BRAZIL
SP Int Assoc Pediat Otorhinol
DE 25-hydroxyvitamin D; immunity; infection; tympanostomy tube; vitamin D
ID VITAMIN-D DEFICIENCY; MULTIVITAMIN-MINERAL SUPPLEMENT; COD-LIVER OIL;
   UNITED-STATES; D INSUFFICIENCY; PILOT RESEARCH; SERUM; INFECTION; RISK;
   ASSOCIATION
AB Objectives: We report the plasma 25-hydroxyvitamin D [25(OH)D] levels of 16 young children who were undergoing ambulatory surgery for placement of tympanostomy tubes.
   Methods: We previously obtained blood samples from young children who were undergoing ambulatory surgery and reported that they had lower blood levels than adults of eicosapentaenoic acid (an omega-3 fatty acid), vitamin A, and selenium. Plasma frozen continuously at -80 degrees C was available from 16 subjects who were undergoing placement of tympanostomy tubes.
   Results: The mean (+/- SD) age of the patients was 3.7 +/- 1.6 years (median, 2.9 years; range, 1.9 to 7.4 years). Sixty-two percent were male; half were white, and half were Hispanic. Sixty-two percent were private patients; the parents reported that half were taking vitamin supplements. None had a history of rickets. None had 25(OH)D levels less than 10 ng/mL; 50% had 25(OH)D levels less than 20 ng/mL (deficient in adults); another 31% had levels from 21 to 29 ng/mL (insufficient in adults).
   Conclusions: Vitamin D is essential for the production of endogenous antimicrobial peptides, and has been linked to seasonal, epidemic influenza A. However, the level of 25(OH)D needed to prevent infection with various human pathogens has not been defined. In view of increasing bacterial resistance and emerging new pathogens, further research on the relationship of infection to 25(OH)D and other nutritional factors is warranted.
C1 [Linday, Linda A.; Dolitsky, Jay N.] New York Eye & Ear Infirm, Dept Otolaryngol, New York, NY USA.
   [Linday, Linda A.] St Lukes Roosevelt Hosp, Dept Pediat, New York, NY USA.
   [Linday, Linda A.] Columbia Univ, Coll Phys & Surg, Dept Pediat, New York, NY USA.
   [Shindledecker, Richard D.] New York Downtown Hosp, Dept Informat Technol, New York, NY USA.
   [Dolitsky, Jay N.] ENT & Allergy Associates LLP, New York, NY USA.
   [Linday, Linda A.; Dolitsky, Jay N.] New York Med Coll, Dept Otolaryngol, Valhalla, NY 10595 USA.
   [Chen, Tai C.; Holick, Michael F.] Boston Univ, Med Ctr, Sect Endocrinol Nutr & Diabet, Dept Med,Vitamin D Skin & Bone Res Lab, Boston, MA USA.
RP Linday, LA (reprint author), 340 W 55th St,Suite 9A, New York, NY 10019 USA.
EM lal14@columbia.edu
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NR 43
TC 14
Z9 15
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD OCT
PY 2008
VL 117
IS 10
BP 740
EP 744
PG 5
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 365WS
UT WOS:000260440800006
PM 18998501
ER

PT J
AU Suzuki, H
   Matsuura, K
   Hiraki, N
   Kadokawa, Y
   Hashida, K
   Udaka, T
   Nagatani, G
AF Suzuki, Hideaki
   Matsuura, Kazuto
   Hiraki, Nobuaki
   Kadokawa, Yohei
   Hashida, Koichi
   Udaka, Tsuyoshi
   Nagatani, Gunji
TI Digastric Muscle Sew-Up Procedure for the Repair of the Floor of the
   Mouth Following Pull-Through Operation for Oral Cancers
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE digastric muscle; floor of mouth; glossectomy; oral cancer; pull-through
   operation; sew-up procedure
ID ABDOMINIS MYOCUTANEOUS FLAP; SQUAMOUS-CELL CARCINOMA; TOTAL GLOSSECTOMY;
   NECK RECONSTRUCTION; FOREARM FLAP; ARTICULATION; LARYNGECTOMY; TONGUE;
   HEAD
AB Objectives: We report the digastric muscle sew-up procedure for the repair of the floor of the mouth following the pull-through operation for advanced oral cancers.
   Methods: Eleven patients with advanced oral cancers (of the tongue in 8 cases and of the floor of the mouth in 3 cases) were retrospectively analyzed. One-third glossectomy and hemiglossectomy were performed in 4 patients each; the other 3 patients underwent tumor resection on the floor of the mouth. After neck dissection and tumor resection via the pull-through approach, the floor of the mouth was repaired simply by sewing the digastric muscle to the mandibular base. The surfaces of the transected musculature of the tongue and the floor of the mouth were left uncovered and exposed to the oral cavity.
   Results: The postoperative wound healing was fairly good in all of the patients. Neck infection or the formation of a fistula on the floor of the mouth was not seen. The patients started transoral ingestion by the 10th postoperative day. Temporary difficulty in swallowing occurred in all patients, but was totally alleviated within I month. Their clarity of speech recovered to a tolerable level.
   Conclusions: We believe that the digastric muscle sew-up procedure is a simple, safe, and timesaving method for the repair of small to medium-sized defects of the floor of the mouth created by ablative surgery in patients with advanced oral cancers.
C1 [Suzuki, Hideaki] Univ Occupat & Environm Hlth, Sch Med, Dept Otorhinolaryngol, Yahatanishi Ku, Kitakyushu, Fukuoka 8078555, Japan.
   [Matsuura, Kazuto] Miyagi Canc Ctr Hosp, Dept Head & Neck Surg, Natori, Miyagi, Japan.
RP Suzuki, H (reprint author), Univ Occupat & Environm Hlth, Sch Med, Dept Otorhinolaryngol, Yahatanishi Ku, 1-1 Iseigaoka, Kitakyushu, Fukuoka 8078555, Japan.
CR de Bree R, 2007, CLIN OTOLARYNGOL, V32, P275, DOI 10.1111/j.1365-2273.2007.01466.x
   Farace F, 2007, J PLAST RECONSTR AES, V60, P583, DOI 10.1016/j.bjps.2006.11.014
   Kimata Y, 2003, LARYNGOSCOPE, V113, P905, DOI 10.1097/00005537-200305000-00024
   Kiyokawa K, 1999, PLAST RECONSTR SURG, V104, P2015, DOI 10.1097/00006534-199912000-00011
   Lim YC, 2007, INT J ORAL MAX SURG, V36, P610, DOI 10.1016/j.ijom.2007.01.009
   Milenovic A, 2006, J CRANIO MAXILL SURG, V34, P340, DOI 10.1016/j.jcms.2006.04.001
   Okazaki M, 2007, J RECONSTR MICROSURG, V23, P243, DOI 10.1055/s-2007-981502
   Szudek J, 2007, ARCH OTOLARYNGOL, V133, P655, DOI 10.1001/archotol.133.7.655
   Tanaka N, 2003, J ORAL MAXIL SURG, V61, P1179, DOI 10.1016/S0278-2391(03)00679-7
   Wakumoto M, 1996, J ORAL REHABIL, V23, P764, DOI 10.1046/j.1365-2842.1996.d01-186.x
NR 10
TC 0
Z9 0
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD OCT
PY 2008
VL 117
IS 10
BP 745
EP 748
PG 4
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 365WS
UT WOS:000260440800007
PM 18998502
ER

PT J
AU Woo, JS
   Hundal, JS
   Sasaki, CT
   Abdelmessih, MW
   Kelleher, SP
AF Woo, Jeong-Soo
   Hundal, Jagdeep S.
   Sasaki, Clarence T.
   Abdelmessih, Mikhail W.
   Kelleher, Stephen P.
TI Reflex Vocal Fold Adduction in the Porcine Model: The Effects of Stimuli
   Delivered to Various Sensory Nerves
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT 88th Annual Meeting of the American-Broncho-Esophagological-Association
CY MAY 01-02, 2008
CL Orlando, FL
SP Amer Broncho Esophagol Assoc
DE afferent nerve; electrical stimulation; glottis; neuron; reflex
AB Objectives: The aim of this study was to identify a panel of sensory nerves capable of eliciting an evoked glottic closure reflex (GCR) and to quantify the glottic closing force (GCF) of these responses in a porcine model.
   Methods: In 5 pigs, the internal branch of the superior laryngeal nerve (iSLN) and the trigeminal, pharyngeal plexus, glossopharyngeal, radial, and intercostal nerves were surgically isolated and electrically stimulated. During stimulation of each nerve, the GCR was detected by laryngeal electromyography and the GCF was measured with a pressure transducer.
   Results: The only nerve that elicited the GCR in the 5 pigs was the iSLN. The average GCF was 288.9 turn Hg.
   Conclusions: This study demonstrates that the only afferent nerve that elicits the GCR in pigs is the iSLN, and that it should remain the focus of research for the rehabilitation of patients with absent or defective reflex vocal fold adduction.
C1 [Sasaki, Clarence T.] Yale Univ, Sch Med, Dept Surg, Otolaryngol Sect, New Haven, CT 06520 USA.
RP Sasaki, CT (reprint author), Yale Univ, Sch Med, Dept Surg, Otolaryngol Sect, 333 Cedar St,POB 208041, New Haven, CT 06520 USA.
CR Bouchetemble P, 2007, LARYNGOSCOPE, V117, P897, DOI 10.1097/MLG.0b013e3180381657
   COHEN S, 1993, ANN OTO RHINOL LARYN, V102, P28
   GODING GS, 1987, OTOLARYNG HEAD NECK, V97, P28
   HAST MH, 1974, BRAIN RES, V73, P229, DOI 10.1016/0006-8993(74)91046-4
   Ozveren MF, 2003, NEUROSURGERY, V52, P1400
   Shaker R, 1998, AM J PHYSIOL-GASTR L, V275, pG521
   SUZUKI M, 1977, ANN OTO RHINOL LARYN, V86, P30
NR 7
TC 3
Z9 3
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD OCT
PY 2008
VL 117
IS 10
BP 749
EP 752
PG 4
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 365WS
UT WOS:000260440800008
PM 18998503
ER

PT J
AU Dogru, S
   Van Daele, D
   Hansen, MR
AF Dogru, Salim
   Van Daele, Douglas
   Hansen, Marlan R.
TI Retrograde Labeling of the Rat Facial Nerve With Carbocyanine Dyes to
   Enhance Intraoperative Identification
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE DiI; DiO; Fast DiO; fluorescence; stereomicroscopy
ID FLUORESCENCE-GUIDED RESECTION; FAST-BLUE; GLIOBLASTOMA-MULTIFORME;
   FLUOROGOLD; TRACERS; DII; SURGERY
AB Objectives: Removal of head and neck neoplasms, especially those of the parotid gland and those of the internal auditory canal and cerebellopontine angle, often requires microdissection of the facial nerve. Displacement or splaying of the nerve can make it difficult to identify facial nerve fibers and/or distinguish them from surrounding tissues. Here we tested a method of labeling the facial nerve with fluorescent lipophilic dyes as a method of providing intraoperative visual confirmation of nerve fibers.
   Methods: The facial nerves of adult rats were retrogradely labeled with 1,1'-dioctadecyl-3,3,3',3'-tetramethylindocarbocyanine perchlorate (DiI), 3,3'-dioctadecyloxacarbocyanine perchlorate (DiO), or 3,3'-dilinoleyloxacarbocyanine perchlorate (Fast DiO) either by direct application to the nerve sheath or by microinjection into the facial muscles. The nerves were examined 30 days after dye application by means of a dissecting stereomicroscope equipped with epifluorescence filters.
   Results: Of the dyes tested, Fast DiO proved to be the most effective, providing labeling of the nerve sufficient to be seen with combined fluorescent and bright field stereomicroscopy. Nerve conduction studies indicated that fluorescent labeling did not adversely affect nerve function.
   Conclusions: These results raise the possibility of using fluorescent lipophilic dyes to label nerves as a method of enhancing identification and distinguishing nerve fibers during surgery.
C1 [Dogru, Salim; Van Daele, Douglas; Hansen, Marlan R.] Univ Iowa, Dept Otolaryngol Head & Neck Surg, Iowa City, IA 52242 USA.
RP Hansen, MR (reprint author), Univ Iowa, Dept Otolaryngol Head & Neck Surg, Iowa City, IA 52242 USA.
CR Anderson DE, 2005, J NEUROSURG, V102, P643, DOI 10.3171/jns.2005.102.4.0643
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   *INV US, FLUOR LIP TRAC PROD
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   Romstock J, 2000, J NEUROSURG, V93, P586, DOI 10.3171/jns.2000.93.4.0586
   Shinoda J, 2003, J NEUROSURG, V99, P597, DOI 10.3171/jns.2003.99.3.0597
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   Tsai EC, 2001, J HISTOCHEM CYTOCHEM, V49, P1111
NR 22
TC 0
Z9 1
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD OCT
PY 2008
VL 117
IS 10
BP 753
EP 758
PG 6
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 365WS
UT WOS:000260440800009
PM 18998504
ER

PT J
AU Wu, VF
   Smith, TL
   Poetker, DM
AF Wu, Vivian F.
   Smith, Timothy L.
   Poetker, David M.
TI Sinocutaneous Fistula Secondary to Chronic Frontal Rhinosinusitis: Case
   Series and Literature Review
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE frontal bone osteomyelitis; frontal sinus fistula; Pott's puffy tumor;
   sinocutaneous fistula
ID POTTS PUFFY TUMOR; INTRACRANIAL COMPLICATIONS; CUTANEOUS FISTULA;
   SINUSITIS; OSTEOMYELITIS
AB Objectives: The purpose of this study was to describe the clinical features of a series of patients in whom sinocutaneous fistula developed in the setting of chronic frontal sinusitis.
   Methods: We performed a retrospective case review of patients with sinocutaneous fistula. Clinical records, imaging, and operative reports were carefully examined. A complete literature review for relevant studies was performed to examine similar cases and possible pathophysiology.
   Results: Three patients with sinocutaneous fistula secondary to frontal sinusitis were identified. All patients underwent successful endoscopic sinus surgery with computer-assisted stereotactic localization and closure of the fistula.
   Conclusions: Development of sinocutaneous fistula secondary to frontal sinusitis is rare, but still occurs in the modem antibiotic era. Definitive management of this disease process requires 1) a frontal sinusotomy ensuring patency of the outflow tract and 2) fistula excision and multilayer closure.
C1 [Smith, Timothy L.] Oregon Hlth & Sci Univ, Dept Otolaryngol Head & Neck Surg, Div Rhinol & Sinus Surg, Portland, OR 97239 USA.
RP Smith, TL (reprint author), Oregon Hlth & Sci Univ, Dept Otolaryngol Head & Neck Surg, Div Rhinol & Sinus Surg, 3181 SW Sam Jackson Pk Rd,PV-01, Portland, OR 97239 USA.
CR Altman KW, 1997, INT J PEDIATR OTORHI, V41, P9, DOI 10.1016/S0165-5876(97)00047-5
   Babu RP, 1996, J NEUROSURG, V84, P110, DOI 10.3171/jns.1996.84.1.0110
   Bambakidis NC, 2001, PEDIATR NEUROSURG, V35, P82, DOI 10.1159/000050395
   Bellaney GJ, 1997, BRIT J DERMATOL, V136, P145, DOI 10.1111/j.1365-2133.1997.tb08777.x
   BLACKSHAW G, 1990, J LARYNGOL OTOL, V104, P574, DOI 10.1017/S0022215100113209
   CLAYMAN GL, 1991, LARYNGOSCOPE, V101, P234
   Davidson L, 2006, J NEUROSURG, V105, P235, DOI 10.3171/ped.2006.105.3.235
   Gallagher RM, 1998, LARYNGOSCOPE, V108, P1635, DOI 10.1097/00005537-199811000-00009
   Goldfarb A, 2004, OTOLARYNG HEAD NECK, V130, P490, DOI 10.1016/j.otohns.2003.10.006
   Maheshwar AA, 2001, J LARYNGOL OTOL, V115, P497
   Marfatia H K, 1997, J Postgrad Med, V43, P102
   Marshall AH, 2000, J LARYNGOL OTOL, V114, P944
   PENDER E S, 1990, Pediatric Emergency Care, V6, P280, DOI 10.1097/00006565-199012000-00008
   REINECKE RD, 1969, AM J OPHTHALMOL, V67, P591
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   SIMONSZ HJ, 1982, DOC OPHTHALMOL, V52, P409, DOI 10.1007/BF01675873
NR 16
TC 2
Z9 2
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD OCT
PY 2008
VL 117
IS 10
BP 759
EP 763
PG 5
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 365WS
UT WOS:000260440800010
PM 18998505
ER

PT J
AU Krause, E
   Louza, JPR
   Hempel, JM
   Wechtenbruch, J
   Rader, T
   Gurkov, R
AF Krause, Eike
   Louza, Julia P. R.
   Hempel, John-Martin
   Wechtenbruch, Juliane
   Rader, Tobias
   Guerkov, Robert
TI Prevalence and Characteristics of Preoperative Balance Disorders in
   Cochlear Implant Candidates
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE balance disorder; cochlear implant; deafness; vertigo; vestibular
   dysfunction
ID VESTIBULAR FUNCTION; VERTIGO
AB Objectives: The aim of this study was to elucidate the frequency and characteristics of preoperative vertigo symptoms in patients who undergo cochlear implantation (CI), in order to differentiate them from Cl-related symptoms.
   Methods: In a prospective observational study, 47 adult Cl candidates were asked about vertigo problems on a questionnaire. A subdivision into 3 groups was done: group A (probable otogenic vertigo), group B (possible otogenic vertigo), and group C (not otogenic vertigo). Horizontal semicircular canal function was measured. Patients with vertigo complaints were compared to patients without vertigo with regard to the presence of abnormal vestibular function findings.
   Results: Twenty-five patients (53%) reported preoperative vertigo problems. In 21 (84%), the patient's history suggested a probable (group A) or possible (group 13) otogenic origin. Patients with vertigo more often had abnormal findings on vestibular function testing than did patients without vertigo. This difference, however, was not statistically significant.
   Conclusions: A considerable number of Cl candidates have preoperative vertigo symptoms. These cannot be explained by horizontal semicircular canal function alone. In order to understand why Cl patients develop postoperative vertigo, analysis of prospective preoperative vestibular function test findings and vertigo symptoms is necessary.
C1 [Krause, Eike; Louza, Julia P. R.; Hempel, John-Martin; Wechtenbruch, Juliane; Guerkov, Robert] Univ Munich, Dept Otorhinolaryngol Head & Neck Surg, D-81377 Munich, Germany.
   [Rader, Tobias] Univ Frankfurt, Dept Otorhinolaryngol Head & Neck Surg, Frankfurt, Germany.
RP Krause, E (reprint author), Univ Munich, Dept Otorhinolaryngol Head & Neck Surg, Marchioninistr 15, D-81377 Munich, Germany.
RI Louza, Julia/H-8555-2013; Gurkov, Robert/K-3536-2013
OI Louza, Julia/0000-0001-8898-6377; Gurkov, Robert/0000-0002-4195-149X
CR Baloh R W, 1989, Acta Otolaryngol Suppl, V468, P323
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   Buchman CA, 2004, LARYNGOSCOPE, V114, P1, DOI 10.1097/00005537-200410001-00001
   COHEN NL, 1991, ANN OTO RHINOL LARYN, V100, P708
   Di Girolamo S, 1999, J LARYNGOL OTOL, V113, P922
   Enticott JC, 2006, OTOL NEUROTOL, V27, P824, DOI 10.1097/01.mao.0000227903.47483.a6
   Filipo R, 2006, ACTA OTO-LARYNGOL, V126, P1266, DOI 10.1080/00016480600678789
   Fina M, 2003, OTOL NEUROTOL, V24, P234, DOI 10.1097/00129492-200303000-00018
   Graham S. S., 1995, Annals of Otology Rhinology and Laryngology, V104, P412
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   Lesinski A, 1998, HNO, V46, P692, DOI 10.1007/s001060050297
   MANGHAM CA, 1987, ANN OTO RHINOL LARYN, V96, P101
   MULCH G, 1978, LARYNG RHINOL OTOL V, V57, P528
   JACOBSON GP, 1990, ARCH OTOLARYNGOL, V116, P424
   OLEARY MJ, 1991, ANN OTO RHINOL LARYN, V100, P695
   POWELL LE, 1995, J GERONTOL A-BIOL, V50, pM28
   Steenerson RL, 2001, OTOL NEUROTOL, V22, P842, DOI 10.1097/00129492-200111000-00021
   Vibert D, 2001, ACTA OTO-LARYNGOL, P29
NR 20
TC 5
Z9 5
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD OCT
PY 2008
VL 117
IS 10
BP 764
EP 768
PG 5
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 365WS
UT WOS:000260440800011
PM 18998506
ER

PT J
AU Mueller, CA
   Khatib, S
   Naka, A
   Temmel, AFP
   Hummel, T
AF Mueller, Christian A.
   Khatib, Saher
   Naka, Asami
   Temmel, Andreas F. P.
   Hummel, Thomas
TI Clinical Assessment of Gustatory Function Before and After Middle Ear
   Surgery: A Prospective Study With a Two-Year Follow-Up Period
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE chorda tympani; clinic; gustation; middle ear surgery; taste
ID CHORDA TYMPANI NERVE; TASTE DISORDERS; SENSATION
AB Objectives: Middle ear surgery can affect gustatory function because of the course of the chorda tympani nerve (CTN) close to the tympanic membrane. The aim of the study was to evaluate the sense of taste before and after middle ear surgery with a test suitable for clinical routine. Moreover, subjective complaints were assessed over a relatively long period of time.
   Methods: Forty-seven patients (26 female, 21 male; mean age, 42 years) were investigated before and 4 days after surgery on both sides of the anterior part of the tongue. Self-assessment of taste function was performed by visual analog scales.
   Results: The mean (+/- SD) taste scores significantly decreased on the side ipsilateral to the operated ear in patients with major manipulation of the CTN (12.0 +/- 4.5 before surgery and 6.9 +/- 4.5 after surgery; p < 0.001), whereas no significant changes were measured in patients with minor manipulation of the CTN (12.5 +/- 3.1 before surgery and 11.2 +/- 3.9 after surgery; p = 0.14). Self-assessed ratings of taste function significantly decreased after surgery in all patients (p < 0.001). Reassessment of subjective taste function after 2 years indicated no persisting complaints.
   Conclusions: Depending on the amount of manipulation of the CTN, taste function is decreased after surgery. However, long-lasting changes of gustatory function seem to be rare.
C1 [Mueller, Christian A.; Khatib, Saher; Naka, Asami; Temmel, Andreas F. P.] Med Univ Vienna, Dept Otorhinolaryngol, A-1090 Vienna, Austria.
   [Hummel, Thomas] Univ Dresden, Sch Med, Dept Otorhinolaryngol, Smell & Taste Clin, Dresden, Germany.
RP Mueller, CA (reprint author), Med Univ Vienna, Dept Otorhinolaryngol, Waehringer Guertel 18-20, A-1090 Vienna, Austria.
CR Chen JM, 2008, LARYNGOSCOPE, V118, P99, DOI 10.1097/MLG.0b013e318156b9f5
   Clark MPA, 2007, OTOL NEUROTOL, V28, P335, DOI 10.1097/01.mao.0000247820.16325.f0
   Franz P, 2003, ACTA OTO-LARYNGOL, V123, P133, DOI 10.1080/00016480310000999
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   Saito T, 2002, ANN OTO RHINOL LARYN, V111, P357
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NR 16
TC 5
Z9 5
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD OCT
PY 2008
VL 117
IS 10
BP 769
EP 773
PG 5
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 365WS
UT WOS:000260440800012
PM 18998507
ER

PT J
AU Lima, LER
   Nita, LM
   Campelo, VES
   Imamura, R
   Tsuji, DH
AF Lima, Leila F. R.
   Nita, Luciana M.
   Campelo, Victor E. S.
   Imamura, Rui
   Tsuji, Domingos H.
TI Morphometric Study on the Anatomy of the Fetal Cricoid Cartilage and
   Comparison Between Its Inner Diameter and Endotracheal Tube Sizes
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE cricoid cartilage; growth; larynx; neonate; orotracheal intubation;
   prematurity
ID INFANT LARYNX; WHOLE-ORGAN; INTUBATION; COLLAGEN
AB Objectives: The high incidence of respiratory disorders is one of the main problems in perinatal medical care. With the increased use of intubation, the incidence of laryngeal injury causing stenosis has also increased. The principal constriction point in the infant's larynx is the midcricoid area. We sought to provide detailed morphometric data on the anatomy of the cricoid cartilage and its relationship with growth and body characteristics of fetuses at 5 to 9 months of gestational age.
   Methods: Nineteen larynges obtained from 17 stillborn infants and 2 newborn infants ranging in gestational age from 5 to 9 months were studied. Measurements of the cricoid cartilage were made with a millimeter-graded caliper.
   Results: Weight was the variable most correlated with cricoid measurements. The cricoid lumen configuration showed an almost elliptic shape and did not change with gestational age. The mean inner subglottic cricoid area was 19.27 +/- 9.62 mm(2) and was related to weight and body surface area. Cricoid growth was more pronounced at the outer portion of the cartilage.
   Conclusions: The cricoid lumen configuration was elliptic, and its mean area was smaller than that of available endotracheal tubes. This lumen area was most influenced by weight and height.
C1 [Lima, Leila F. R.; Nita, Luciana M.; Campelo, Victor E. S.; Imamura, Rui; Tsuji, Domingos H.] Univ Sao Paulo, Sch Med, Clin Hosp, Dept Otorhinolaryngol, Sao Paulo, Brazil.
RP Lima, LER (reprint author), 643 Apt 131, BR-05410001 Sao Paulo, Brazil.
CR COHEN SR, 1993, ANN OTO RHINOL LARYN, V102, P655
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NR 17
TC 2
Z9 3
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD OCT
PY 2008
VL 117
IS 10
BP 774
EP 780
PG 7
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 365WS
UT WOS:000260440800013
PM 18998508
ER

PT J
AU Bang, CI
   Paik, SY
   Sun, DI
   Joo, YH
   Kim, MS
AF Bang, Choong-Il
   Paik, Soon-Young
   Sun, Dong-Il
   Joo, Young-Hoon
   Kim, Min-Sik
TI Cell Growth Inhibition and Down-Regulation of Survivin by Silibinin in a
   Laryngeal Squamous Cell Carcinoma Cell Line
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE laryngeal cancer; silibinin; survivin
ID EXPRESSION; APOPTOSIS; CANCER; SUPPRESSION; ANGIOGENESIS; ARREST
AB Objectives: Abnormalities in the regulation of apoptotic cell death have been shown to have an important effect on the pathogenesis and progression of cancer. Survivin, which is identified in most cancers and has recently been identified as an inhibitor of apoptosis, is a potential therapeutic target for cancer management. We investigated cell growth, apoptosis, and expression of survivin in laryngeal squamous cell carcinoma cell lines after treatment with the bioactive compound silibinin.
   Methods: Cultured human laryngeal squamous cell carcinoma SNU-46 cells were treated with different concentrations of silibinin, and the degree of cell growth and apoptosis was analyzed. Additionally, survivin protein and messenger RNA were analyzed by Western immunoblotting and reverse transcription-polymerase chain reaction.
   Results: Silibinin inhibited the growth of SNU-46 cells in a both dose- and time-dependent manner (p < 0.01). Upon fluorescence-activated cell sorter analysis, silibinin (200 mu mol/L) treatment increased the proportion of apoptotic cells from 7% to 40%. At high concentrations (more than 150 mu mol/L), silibinin greatly reduced messenger RNA and protein expression of survivin.
   Conclusions: Our findings demonstrate that silibinin induced apoptosis of laryngeal squamous carcinoma cells by a mechanism involving decreased survivin expression, which suggests the possibility that silibinin may be an effective treatment of laryngeal cancers.
C1 [Bang, Choong-Il; Sun, Dong-Il; Joo, Young-Hoon; Kim, Min-Sik] Catholic Univ Korea, Sch Med, Dept Otolaryngol Head & Neck Surg, Seoul 137040, South Korea.
   [Paik, Soon-Young] Catholic Univ Korea, Sch Med, Dept Immunol, Seoul 137040, South Korea.
RP Kim, MS (reprint author), Catholic Univ Korea, Kangnam St Marys Hosp, Dept Otolaryngol Head & Neck Surg, Panpo Dong 505, Seoul 137040, South Korea.
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NR 22
TC 12
Z9 12
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD OCT
PY 2008
VL 117
IS 10
BP 781
EP 785
PG 5
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 365WS
UT WOS:000260440800014
PM 18998509
ER

PT J
AU Ribeiro, FDQ
   Guaraldo, L
   Borges, JD
   Vianna, MR
   Eckley, CA
AF Quintanilha Ribeiro, Fernando de Andrade
   Guaraldo, Lusiele
   Borges, Janaina de Padua
   Vianna, Maria Regina
   Eckley, Claudia A.
TI Study of Wound Healing in Rats Treated With Topical and Injected
   Mitomycin C
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE injection; mitomycin C; rat; topical; wound healing
ID ENDOSCOPIC SINUS SURGERY; LARYNGOTRACHEAL RECONSTRUCTION; AIRWAY
   STENOSIS; DOUBLE-BLIND; MODEL; COMPLICATIONS; FIBROBLASTS; PREVENTION;
   ADHESIONS; PROTEINS
AB Objectives: Mitomycin C, a widely used chemotherapeutic drug, has been proposed as a potential adjuvant for the control of scar tissue in surgical wounds because of its capacity to inhibit fibroblast proliferation. The current study used a combination of topical and injected mitomycin C to slow the healing process of surgical wounds in rats.
   Methods: An experimental model of surgical wounding at the dorsum of rats was used. A total of 43 animals were subdivided into 3 groups: control, topical mitomycin C, and a combination of topical treatment and intradermal injections of the drug at 30 and 60 days after the initial topical treatment. After 3 months, the animals were painlessly sacrificed and the surgical scars were removed for microscopic analysis.
   Results: The group that received only topical mitomycin C presented milder inflammatory signs and consequently had a less intense healing process than the control group. The group treated with a combination of both topical and injected mitomycin C presented results comparable to those of the control group.
   Conclusions: The toxic characteristics of mitomycin C were most likely responsible for the greater tissue damage that occurred when it was used in the injected form, causing increased scar tissue formation. Mitomycin C slows the healing process of surgical wounds when used topically, but causes enhanced scar tissue formation when injected.
C1 [Quintanilha Ribeiro, Fernando de Andrade; Guaraldo, Lusiele; Borges, Janaina de Padua; Vianna, Maria Regina; Eckley, Claudia A.] Santa Casa Sch Med, Dept Otolaryngol, Sao Paulo, Brazil.
RP Eckley, CA (reprint author), Rua Joaquim Floriano 101,3 Andar, BR-04534010 Sao Paulo, Brazil.
RI ECKLEY, CLAUDIA/C-8174-2012
OI ECKLEY, CLAUDIA/0000-0001-7992-5185
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NR 33
TC 1
Z9 1
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD OCT
PY 2008
VL 117
IS 10
BP 786
EP 790
PG 5
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 365WS
UT WOS:000260440800015
ER

PT J
AU Benjamin, B
   Holinger, LD
AF Benjamin, Bruce
   Holinger, Lauren D.
TI Laryngeal complications of endotracheal intubation
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE laryngeal trauma; laryngoscopy; long-term intubation; posterior glottic
   stenosis; subglottic stenosis
ID ACQUIRED SUBGLOTTIC STENOSIS; INTENSIVE-CARE-UNIT; POSTERIOR GLOTTIC
   STENOSIS; PROLONGED INTUBATION; TRACHEAL TUBE; CRICOID SPLIT; CHILDREN;
   AIRWAY; INJURIES; INFANTS
AB An endotracheal tube placed in the larynx, even for a short time, causes at least superficial mucosal damage, an injury that normally heals readily. Long-term intubation, on the other hand, may cause pressure necrosis that can extend into submucosa, perichondrium, and eventually cartilage. The sites of involvement include the medial surface of the arytenoid cartilages, vocal processes, cricoarytenoid joints, posterior glottis, and subglottis. We review the pathogenesis, endoscopic recognition, classification, and progression of intubation injuries and examine the many variables that influence them. Diagrammatic flow charts trace the acute injuries through to their chronic sequelae, including subglottic stenosis, which is commoner in infants and children, and posterior glottic stenosis, which is commoner in adults. Systematic endoscopic assessment, under general anesthesia, using rigid telescopes to evaluate laryngeal damage during intubation is recommended and critically discussed. Endoscopy permits an informed judgment with regard to continuation of intubation. Depending on the severity and depth of ulceration, intubation can be continued (sometimes with a tube of smaller diameter) or tracheotomy performed, with an awareness of the attendant risks and benefits. Unnecessary tracheotomies may be avoided. Further, it may be possible to minimize untoward outcomes of prolonged intubation by using management techniques directed at known risk factors.
C1 [Holinger, Lauren D.] Chicago Childrens Mem Hosp, Div Otolaryngol, Chicago, IL 60614 USA.
   [Holinger, Lauren D.] Northwestern Univ, Dept Otolaryngol Head & Neck Surg, Chicago, IL 60611 USA.
   [Benjamin, Bruce] Royal N Shore Hosp, Dept Otolaryngol Head & Neck Surg, Sydney, NSW, Australia.
   [Benjamin, Bruce] Royal Alexandra Hosp Children, Dept Otolaryngol Head & Neck Surg, Sydney, NSW, Australia.
RP Holinger, LD (reprint author), Chicago Childrens Mem Hosp, Div Otolaryngol, Box 25, Chicago, IL 60614 USA.
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NR 52
TC 5
Z9 5
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD SEP
PY 2008
VL 117
IS 9
SU 200
BP 2
EP 20
PN 2
PG 19
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 353PG
UT WOS:000259579400001
ER

PT J
AU Chang, EH
   Hamilton, GS
AF Chang, Eugene Hanyoung
   Hamilton, Grant S.
TI Novel technique for peritonsillar abscess drainage
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE incision and drainage; peritonsillar abscess; tonsillitis
ID PEDIATRIC-POPULATION
AB Objectives: We propose a novel technique for peritonsillar abscess (PTA) drainage in which the patient is lying in the Trendelenburg position. We provide evidence that this novel technique is relatively safe and effective in PTA drainage.
   Methods: We queried otolaryngology training programs in regard to techniques of PTA drainage after receiving Institutional Review Board approval. Respondents were asked to rate their own level of success in draining PTAs, as well as the perceived satisfaction and comfort of the patient. These were rated on a scale of 1 (never successful or comfortable) to 5 (always successful or comfortable).
   Results: We collected 138 responses. The respondents included residents (67%), faculty (30%), and medical students (3%). The overwhelming majority of respondents placed the patient in a seated position (97%); only 4 respondents used the Trendelenberg position. On average, physicians who drained PTAs in the Trendelenberg versus the seated position had a higher success rating (5 versus 4.37) and a higher patient comfort rating (4.75 versus 3.31).
   Conclusions: We propose a novel PTA drainage technique in which the patient is in the Trendelenburg position. We provide evidence that our technique is rarely used in otolaryngology, and provides success rates and patient comfort levels that are greater than those of the current standard of the seated position.
C1 [Chang, Eugene Hanyoung; Hamilton, Grant S.] Univ Iowa, Hosp & Clin, Dept Otolaryngol, Iowa City, IA 52242 USA.
RP Chang, EH (reprint author), Univ Iowa, Hosp & Clin, Dept Otolaryngol, 200 Hawkins Dr, Iowa City, IA 52242 USA.
CR Bluestone CD, 2003, PEDIAT OTOLARYNGOLOG
   Cummings CW, 2005, CUMMINGS OTOLARYNGOL
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   Lore JM, 2005, ATLAS HEAD NECK SURG
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NR 8
TC 1
Z9 1
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD SEP
PY 2008
VL 117
IS 9
BP 637
EP 640
PN 1
PG 4
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 352MR
UT WOS:000259501800001
PM 18834063
ER

PT J
AU Ushio, M
   Iwasaki, S
   Chihara, Y
   Murofushi, T
AF Ushio, Munetaka
   Iwasaki, Shinichi
   Chihara, Yasuhiro
   Murofushi, Toshihisa
TI Abnormal deviation of subjective visual horizontal in patients with
   vestibular schwannoma
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE acoustic neuroma; caloric test; ocular torsion; subjective visual
   horizontal; vestibular evoked myogenic potential; vestibular schwannoma
ID MYOGENIC POTENTIALS; DEAFFERENTATION; GENTAMICIN
AB Objectives: This study was aimed to examine the correlation between the results of subjective visual horizontal (SVH) and other vestibular function tests in patients with untreated unilateral vestibular schwannoma (VS).
   Methods: The subjects comprised 40 consecutive patients (17 men, 23 women) with VS who underwent vestibular function tests before surgery and had surgically and histopathologically confirmed unilateral VS. The vestibular function tests included SVH, caloric, and vestibular evoked myogenic potential (VEMP) tests.
   Results: Of the 40 patients, 31 (77.5%) showed deviation of the SVH toward the affected side down. Especially in 8 patients (20.0%), abnormal deviation (more than 2.2 degrees) toward the affected side down was seen. None of the patients showed abnormal deviation toward the unaffected side down. On the caloric test, the proportion of absent caloric responses and the percent canal paresis in patients with an abnormal SVH was significantly higher than those in patients with a normal SVH. The proportion of abnormal VEMP responses was higher and the percent VEMP asymmetry was smaller in patients with an abnormal SVH than in patients with a normal SVH; however, the differences were not significant.
   Conclusions: Abnormal results on the caloric test and/or VEMP test were more frequently seen in VS patients with abnormal deviation of the SVH.
C1 [Ushio, Munetaka] Univ Tokyo, Grad Sch Med, Dept Otolaryngol, Bunkyo Ku, Tokyo 1138655, Japan.
   [Murofushi, Toshihisa] Tokyo Postal Serv Agcy Hosp, Dept Otolaryngol, Tokyo, Japan.
RP Ushio, M (reprint author), Univ Tokyo, Grad Sch Med, Dept Otolaryngol, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1138655, Japan.
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NR 11
TC 4
Z9 5
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD SEP
PY 2008
VL 117
IS 9
BP 641
EP 644
PN 1
PG 4
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 352MR
UT WOS:000259501800002
PM 18834064
ER

PT J
AU de Heyning, PV
   Vermeire, K
   Diebl, M
   Nopp, P
   Anderson, I
   De Ridder, D
AF de Heyning, Paul Van
   Vermeire, Katrien
   Diebl, Martina
   Nopp, Peter
   Anderson, Ilona
   De Ridder, Dirk
TI Incapacitating unilateral tinnitus in single-sided deafness treated by
   cochlear implantation
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE cochlear implantation; single-sided deafness; tinnitus
ID TRANSCRANIAL MAGNETIC STIMULATION; ENRICHED ACOUSTIC ENVIRONMENT; NOISE
   TRAUMA; AUDITORY-CORTEX; SUPPRESSION; REORGANIZATION; NEUROSTIMULATION
AB Objectives: Tinnitus is a well-known, difficult-to-treat symptom of hearing loss. Users of cochlear implants (CIs) have reported a reduction in tinnitus following implantation for bilateral severe-to-profound deafness. This study assessed the effect of electrical stimulation via a CI on tinnitus in subjects with unilateral deafness and ipsilateral tinnitus who underwent implantation in an attempt to treat tinnitus with the CI.
   Methods: Twenty-one subjects who complained of severe intractable tinnitus that was unresponsive to treatment received a CI. Tinnitus loudness was measured with a Visual Analog Scale; loudness percepts were recorded with the device activated and deactivated. Tinnitus distress was measured with the Tinnitus Questionnaire before and after implantation.
   Results: Electrical stimulation via a CI resulted in a significant reduction in tinnitus loudness (mean +/- SD; 1 year after implantation, 2.4 +/- 1.8; 2 years after implantation, 2.5 +/- 1.9; before implantation, 8.5 +/- 1.3). With the device deactivated, tinnitus loudness was still reduced to between 6.1 and 7.0 over 24 months. The Tinnitus Questionnaire revealed a significant positive effect of CI stimulation.
   Conclusions: Unilateral tinnitus resulting from single-sided deafness can be treated with electrical stimulation via a CI. The outcomes of this pilot study demonstrate a new method for treatment of tinnitus in select subjects, perhaps an important new indication for cochlear implantation.
C1 [de Heyning, Paul Van; Vermeire, Katrien] Univ Antwerp, Dept Otorhinolaryngol Head & Neck Surg, Univ Antwerp Hosp, B-2650 Edegem, Belgium.
   [De Ridder, Dirk] Univ Antwerp, Dept Neurosurg, Univ Antwerp Hosp, B-2650 Edegem, Belgium.
   [Diebl, Martina; Nopp, Peter; Anderson, Ilona] MED EL GmbH, Innsbruck, Austria.
RP de Heyning, PV (reprint author), Univ Antwerp, Dept Otorhinolaryngol Head & Neck Surg, Univ Antwerp Hosp, Wilrijkstr 10, B-2650 Edegem, Belgium.
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NR 35
TC 0
Z9 0
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD SEP
PY 2008
VL 117
IS 9
BP 645
EP 652
PN 1
PG 8
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 352MR
UT WOS:000259501800003
ER

PT J
AU Lombardi, D
   Galtelli, C
   Khrais, T
   Morassi, ML
   Nicolai, P
AF Lombardi, Davide
   Galtelli, Cristina
   Khrais, Tarek
   Morassi, Maria Laura
   Nicolai, Piero
TI Giant hypervascular lesion of the sinonasal tract invading the anterior
   skull base and orbit: A puzzling case
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE angiosarcoma; intravascular papillary endothelial hyperplasia; lobular
   capillary hemangioma; Masson's tumor; sinonasal tract
ID PAPILLARY ENDOTHELIAL HYPERPLASIA; LOBULAR CAPILLARY HEMANGIOMA;
   PYOGENIC GRANULOMA GRAVIDARUM; MAXILLARY SINUS; NASAL CAVITY; NOSE
AB The sinonasal tract may be involved in a wide variety of hypervascular lesions, either benign or malignant, and differential diagnosis may be challenging. We present the case of a 26-year-old man with an aggressive ethmoid hypervascular mass invading the anterior skull base and orbit. Because of massive intraoperative bleeding and difficult dissection of the lesion from the periorbita, the planned cranioendoscopic approach had to be converted into a standard craniofacial resection by a combined Lynch and coronal incision. The definitive diagnosis was consistent with lobular capillary hemangioma associated with intravascular papillary endothelial hyperplasia. Two years after surgery, the patient is free of disease. Lobular capillary hemangioma is a hypervascular lesion that may involve the sinonasal tract. The case presented herein is exceptional, both in the presentation and in the difficulties encountered in diagnosis and treatment, because of the concurrence of lobular capillary hemangioma and intravascular papillary endothelial hyperplasia.
C1 [Lombardi, Davide; Galtelli, Cristina; Khrais, Tarek; Nicolai, Piero] Univ Brescia, Dept Otorhinolaryngol, I-25123 Brescia, Italy.
   [Morassi, Maria Laura] Univ Brescia, Dept Pathol, I-25123 Brescia, Italy.
RP Lombardi, D (reprint author), Univ Brescia, Dept Otorhinolaryngol, Piazza Spedali Civili 1, I-25123 Brescia, Italy.
FU Department of Pathology of the Queen Elizabeth Hospital (Kowloon, Hong
   Kong)
FX We are very grateful to Dr J. K. Chan from the Department of Pathology
   of the Queen Elizabeth Hospital (Kowloon, Hong Kong) for the enormous
   support received in achieving definitive diagnosis in this case.
CR Barnes L., 2005, WHO CLASSIFICATION T, P9
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NR 25
TC 2
Z9 2
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD SEP
PY 2008
VL 117
IS 9
BP 653
EP 658
PN 1
PG 6
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 352MR
UT WOS:000259501800004
PM 18834066
ER

PT J
AU Jense, RJ
   Souter, K
   Davies, J
   Romig, C
   Panneerselvam, A
   Maronian, N
AF Jense, Ryan J.
   Souter, Karen
   Davies, Jo
   Romig, Christopher
   Panneerselvam, Ashok
   Maronian, Nicole
TI Dexmedetomidine sedation for laryngeal framework surgery
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE anesthesia; larynx; medialization; thyroplasty
ID GENERAL-ANESTHESIA; THYROPLASTY; EFFICACY
AB Objectives: Sedation for laryngeal framework surgery has lacked easy modulation between appropriate pain control, airway protection, and the alertness appropriate for vocal testing. Our objective was to determine whether dexmedetomidine hydrochloride could safely and effectively be used as the sole intravenous anesthetic agent in conjunction with local anesthesia for laryngeal framework procedures.
   Methods: We undertook a prospective review of 14 patients who underwent laryngeal framework surgery with dexmedetomidine anesthesia in 2004 and 2005. All dexmedetomidine doses, sedation levels, and vital signs, including blood pressure, heart rate, respiratory rate, and oxygen saturation level, were recorded every 15 minutes by the anesthesiologist throughout the duration of the procedures. Operative conditions were noted by the surgeon, focusing special attention on airway protection, patient arousability, and patient comfort.
   Results: Dexmedetomidine sedation produced hemodynamic and respiratory values that were maintained near preoperative values, and overall pharyngeal-laryngeal integrity provided superior operating conditions for the patient and the operating surgeon.
   Conclusions: We believe that dexmedetomidine provides excellent sedative and operative conditions for awake laryngeal framework procedures. Coupled with local anesthesia, dexmedetomidine produced virtually no undesirable hemodynamic or respiratory effects, while allowing for adequate sedation the majority of the time. The operative conditions were markedly improved over those of previous standard monitored anesthesia regimens.
C1 [Jense, Ryan J.; Souter, Karen; Davies, Jo; Romig, Christopher; Panneerselvam, Ashok] Univ Washington, Dept Anesthesiol, Seattle, WA 98195 USA.
   [Maronian, Nicole] Univ Hosp Case Med Ctr, Dept Otolaryngol, Cleveland, OH 44106 USA.
RP Maronian, N (reprint author), Univ Hosp Case Med Ctr, Dept Otolaryngol Head & Neck Surg, 11100 Euclid Ave,LKS 5045, Cleveland, OH 44106 USA.
CR *ABB LAB, 2004, PREC DEXM HYDR INJ P
   *AM SOC AN, 2005, ASA PHYS CLASS SYST
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NR 17
TC 2
Z9 4
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD SEP
PY 2008
VL 117
IS 9
BP 659
EP 664
PN 1
PG 6
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 352MR
UT WOS:000259501800005
PM 18834067
ER

PT J
AU Bento, RF
   Salomone, R
   Brito, R
   Tsuji, RK
   Hausen, M
AF Bento, Ricardo F.
   Salomone, Raquel
   Brito, Rubens
   Tsuji, Robinson K.
   Hausen, Mariana
TI Partial lesions of the intratemporal segment of the facial nerve: Graft
   versus partial reconstruction
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE anastomosis; facial paralysis; graft; surgical therapy; trauma
ID FIBRIN TISSUE ADHESIVE; PARALYSIS; BONE; FRACTURES; INJURY
AB Objectives: In cases of partial lesions of the intratemporal segment of the facial nerve, should the surgeon perform an intraoperative partial reconstruction, or partially remove the injured segment and place a graft? We present results from partial lesion reconstruction on the intratemporal segment of the facial nerve.
   Methods: A retrospective study on 42 patients who presented partial lesions on the intratemporal segment of the facial nerve was performed between 1988 and 2005. The patients were divided into 3 groups based on the procedure used: interposition of the partial graft on the injured area of the nerve (group 1; 12 patients); keeping the preserved part and performing tubulization (group 2; 8 patients); and dividing the parts of the injured nerve (proximal and distal) and placing a total graft of the sural nerve (group 3; 22 patients).
   Results: Fracture of the temporal bone was the most frequent cause of the lesion in all groups, followed by iatrogenic causes (p < 0.005). Those who obtained results lower than or equal to III on the House-Brackmann scale were 1 (8.3%) of the patients in group 1, none (0.0%) of the patients in group 2, and 15 (68.2%) of the patients in group 3 (p < 0.001).
   Conclusions: The best surgical technique for therapy of a partial lesion of the facial nerve is still questionable. Among these 42 patients, the best results were those from the total graft of the facial nerve.
C1 [Bento, Ricardo F.; Salomone, Raquel; Brito, Rubens; Tsuji, Robinson K.; Hausen, Mariana] Univ Sao Paulo, Dept Otolaryngol, Sch Med, BR-05403000 Sao Paulo, Brazil.
RP Bento, RF (reprint author), Univ Sao Paulo, Dept Otolaryngol, Sch Med, Av Dr Eneas Carvalho Aguiar 255,6 Andar,Sala 6167, BR-05403000 Sao Paulo, Brazil.
EM rbento@gmail.com
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NR 16
TC 3
Z9 5
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD SEP
PY 2008
VL 117
IS 9
BP 665
EP 669
PN 1
PG 5
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 352MR
UT WOS:000259501800006
PM 18834068
ER

PT J
AU Chheda, NN
   Postma, GN
AF Chheda, Neil N.
   Postma, Gregory N.
TI Patient compliance with proton pump inhibitor therapy in an
   otolaryngology practice
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE gastroesophageal reflux; laryngopharyngeal reflux; proton pump
   inhibitor; reflux
ID GASTROESOPHAGEAL-REFLUX DISEASE; LARYNGOPHARYNGEAL REFLUX; ACID
   SUPPRESSION; ADHERENCE
AB Objectives: Proton pump inhibitors (PPIs) are used for the treatment of numerous otolaryngological disorders. It has been demonstrated that administration of the medication 15 to 45 minutes before a meal optimizes acid suppression. The rate of compliance with optimal PPI dosage patterns in an otolaryngology practice is not known. We sought to determine the rate of PPI compliance in patients seen in an otolaryngology practice.
   Methods: We conducted an interview at a tertiary voice and swallowing center of 200 consecutive patients who were taking PPIs.
   Results: Overall, 54% of patients took their PPI in an optimal manner. The rate of compliance was significantly higher for patients who had their PPI prescribed by an otolaryngologist (62%) than for patients whose PPI was prescribed by a non-otolaryngologist (40%).
   Conclusions: Nearly half of all patients seen at a voice and swallowing center were not compliant with optimal PPI usage. This percentage is similar to that found for other long-term medications. Patient education can lead to higher rates of compliance, improved acid control, and possibly improved treatment outcomes.
C1 [Postma, Gregory N.] Med Coll Georgia, Dept Otolaryngol, Ctr Voice & Swallowing Disorders, Augusta, GA 30912 USA.
RP Postma, GN (reprint author), Med Coll Georgia, Dept Otolaryngol, Ctr Voice & Swallowing Disorders, 1120 15th St, Augusta, GA 30912 USA.
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NR 14
TC 4
Z9 4
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD SEP
PY 2008
VL 117
IS 9
BP 670
EP 672
PN 1
PG 3
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 352MR
UT WOS:000259501800007
PM 18834069
ER

PT J
AU Omori, K
   Tada, Y
   Suzuki, T
   Nomoto, Y
   Matsuzuka, T
   Kobayashi, K
   Nakamura, T
   Kanemaru, S
   Yamashita, M
   Asato, R
AF Omori, Koichi
   Tada, Yasuhiro
   Suzuki, Teruhisa
   Nomoto, Yukio
   Matsuzuka, Takashi
   Kobayashi, Ken
   Nakamura, Tatsuo
   Kanemaru, Shinichi
   Yamashita, Masaru
   Asato, Ryo
TI Clinical application of in situ tissue engineering using a scaffolding
   technique for reconstruction of the larynx and trachea
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE airway; larynx; scaffold; tissue engineering; trachea
ID COLLAGEN SPONGE; SUBGLOTTIC STENOSIS; PROSTHESIS; MANAGEMENT
AB Objectives: The objective of the present study was to demonstrate the efficacy of the clinical application of in situ tissue engineering using a scaffolding technique for laryngeal and tracheal tissue.
   Methods: We have developed a tissue scaffold made from a Marlex mesh tube covered by collagen sponge. Based on successful animal experimental studies, in situ tissue engineering with a scaffold implant was applied to repair the larynx and trachea in 4 patients.
   Results: In 1 patient with subglottic stenosis, the thyroid cartilage, cricoid cartilage, and cervical trachea with scarring and a granulation were resected and reconstructed by use of the scaffold. In 3 patients with thyroid cancer, the trachea and cri coid cartilage with tumor invasion were resected and the scaffold was implanted into the defect. Postoperative endoscopy during the observation period of 8 to 34 months showed a well-epithelialized airway lumen without any obstruction.
   Conclusions: Our current technique of in situ tissue engineering using a scaffold shows great potential for use in the regeneration of airway defects.
C1 [Omori, Koichi; Tada, Yasuhiro; Suzuki, Teruhisa; Nomoto, Yukio; Matsuzuka, Takashi; Kobayashi, Ken] Fukushima Med Univ, Dept Otolaryngol, Sch Med, Fukushima 9601295, Japan.
   [Nakamura, Tatsuo] Kyoto Univ, Dept Bioartificial Organs, Inst Frontier Med Sci, Kyoto, Japan.
   [Kanemaru, Shinichi; Yamashita, Masaru; Asato, Ryo] Kyoto Univ, Dept Otolaryngol Head & Neck Surg, Postgrad Med Sch, Kyoto, Japan.
RP Omori, K (reprint author), Fukushima Med Univ, Dept Otolaryngol, Sch Med, 1 Hikarigaoka, Fukushima 9601295, Japan.
RI Yamashita, Masaru/B-2411-2009
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NR 14
TC 51
Z9 52
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD SEP
PY 2008
VL 117
IS 9
BP 673
EP 678
PN 1
PG 6
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 352MR
UT WOS:000259501800008
PM 18834070
ER

PT J
AU Bondy, P
   Grant, T
AF Bondy, Peter
   Grant, Thomas
TI Lemierre's syndrome: What are the roles for anticoagulation and
   long-term antibiotic therapy?
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE antibiotics; anticoagulation; syndrome; thrombosis
ID THROMBOPHLEBITIS; THROMBOSIS
AB Objectives: We wanted to describe what Lemierre's syndrome is and what risk factors may be involved, and to understand the roles, if any, of antibiotics and anticoagulants in the treatment of this syndrome.
   Methods: We performed a review of the pertinent literature regarding Lemierre's syndrome, as well as a review of otology, obstetrics and gynecology, and internal medicine literature looking at both anticoagulation and long-term antibiotic treatment for septic thrombosis.
   Results: The vast majority of patients with Lemierre's syndrome are successfully treated nonsurgically with antibiotics and, often, anticoagulation as well. Surgical intervention is reserved for those cases with persistent showering of septic emboli or continued propagation of the thrombosis. Although anticoagulation is commonly used in other specialties for similar septic thromboses, its role in Lemierre's syndrome is unclear at the present.
   Conclusions: Because Lemierre's syndrome is so rare, it is difficult to ascertain absolutely the need for either anticoagulation or long-term antibiotic therapy. At this time, the risks and benefits of providing either therapy must be weighed against the potential complications of incompletely treating septic thrombosis.
C1 [Bondy, Peter; Grant, Thomas] USN, Med Ctr, Dept Otolaryngol, Portsmouth, VA 23708 USA.
RP Bondy, P (reprint author), USN, Med Ctr, Dept Otolaryngol, 27 Effingham St, Portsmouth, VA 23708 USA.
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NR 10
TC 30
Z9 30
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD SEP
PY 2008
VL 117
IS 9
BP 679
EP 683
PN 1
PG 5
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 352MR
UT WOS:000259501800009
PM 18834071
ER

PT J
AU Mortensen, M
   Woo, P
AF Mortensen, Melissa
   Woo, Peak
TI High-speed imaging used to detect vocal fold paresis: A case report
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE high-speed imaging; vocal fold paresis
ID VIBRATION; KYMOGRAPHY
AB High-speed imaging has been used to study vocal fold vibration and has been shown to provide additional information in aid of our understanding of pathologic vocal fold vibration. This is the first case report of vocal fold paresis diagnosed by high-speed imaging. An 18-year-old girl presented with intermittent voice loss that had been present for 4 years. The patient had been seen by other otolaryngologists and had been given proton pump inhibitors without any improvement in her voice. Her voice was diplophonic. The patient was examined by rigid stroboscopy and was found to have a predominantly open phase pattern but a normal vibratory pattern. High-speed photography showed a distinct vibratory frequency for each vocal fold, suggestive of a paresis pattern. Laryngeal electromyography confirmed the diagnosis of vocal fold paresis. A computed tomographic scan of the larynx and chest showed a thymoma. After thymectomy, the patient recovered full voice function. High-speed imaging is useful for the clinical evaluation of pathologic vocal fold vibration and can detect subtle features of paralysis that may not be detected on fiberoptic endoscopy and rigid stroboscopy. The additional information from high-speed imaging helped to make the diagnosis of vocal fold paresis in this patient.
C1 [Mortensen, Melissa; Woo, Peak] Mt Sinai Med Ctr, Dept Otolaryngol Head & Neck Surg, New York, NY 10029 USA.
RP Woo, P (reprint author), Mt Sinai Med Ctr, Dept Otolaryngol Head & Neck Surg, 1 Gustave L Levy Pl,Box 1189, New York, NY 10029 USA.
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NR 12
TC 10
Z9 10
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD SEP
PY 2008
VL 117
IS 9
BP 684
EP 687
PN 1
PG 4
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 352MR
UT WOS:000259501800010
PM 18834072
ER

PT J
AU Samuels, TL
   Handler, E
   Syring, ML
   Pajewski, NM
   Blumin, JH
   Kerschner, JE
   Johnston, N
AF Samuels, Tina L.
   Handler, Ethan
   Syring, Michael L.
   Pajewski, Nicholas M.
   Blumin, Joel H.
   Kerschner, Joseph E.
   Johnston, Nikki
TI Mucin gene expression in human laryngeal epithelia: Effect of
   laryngopharyngeal reflux
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE laryngopharyngeal reflux; mucin; pepsin; reflux
ID GASTROESOPHAGEAL-REFLUX; DISEASE; PEPSIN; CANCER; ACID; PROTECTION;
   DISORDERS; CARCINOMA; INJURY; VOICE
AB Objectives: We sought to document the mucin gene profile in normal human laryngeal epithelium and compare it with that in patients with reflux-attributed laryngeal injury or disease. We also investigated the effect of low pH with or without pepsin on mucin messenger RNA levels in vitro.
   Methods: Laryngeal biopsy specimens were obtained from 3 patients with clinically diagnosed laryngopharyngeal reflux and from 2 control subjects who had no signs or symptoms of reflux. Signs and symptoms were assessed by the Reflux Finding Score and the Reflux Symptom Index, respectively. Reverse transcription-polymerase chain reaction (RT-PCR) was performed to establish the mucin gene profile. Human hypopharyngeal epithelial cells were exposed to pH 7, 5, 4, and 2 with and without pepsin (0.1 mg/mL) for 20 minutes at 37 degrees C, and expression of selected mucins was analyzed via real-time RT-PCR.
   Results: Mucin 1-5, 7, 9, 13, 15, 16, and 18-20 transcripts were detected in normal laryngeal epithelium, whereas mucin 6, 8, and 17 transcripts were not. Mucins 2, 3, and 5 were expressed at reduced levels in patients with reflux-attributed laryngeal injury or disease. These mucin genes were up-regulated after exposure to low pH in vitro (p < 0.005). Pepsin inhibited this up-regulation (p < 0.001).
   Conclusions: Reflux laryngitis is associated with down-regulation of mucin gene expression.
C1 [Samuels, Tina L.; Handler, Ethan; Syring, Michael L.; Blumin, Joel H.; Kerschner, Joseph E.; Johnston, Nikki] Med Coll Wisconsin, Dept Otolaryngol & Commun Sci, Milwaukee, WI 53226 USA.
   [Pajewski, Nicholas M.] Med Coll Wisconsin, Div Biostat, Dept Populat Hlth, Milwaukee, WI 53226 USA.
RP Johnston, N (reprint author), Med Coll Wisconsin, Dept Otolaryngol & Commun Sci, 9200 W Wisconsin Ave, Milwaukee, WI 53226 USA.
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NR 30
TC 27
Z9 28
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD SEP
PY 2008
VL 117
IS 9
BP 688
EP 695
PN 1
PG 8
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 352MR
UT WOS:000259501800011
PM 18834073
ER

PT J
AU Ohno, T
   French, LC
   Hirano, S
   Ossoff, RH
   Rousseau, B
AF Ohno, Tsunehisa
   French, Lesley C.
   Hirano, Shigeru
   Ossoff, Robert H.
   Rousseau, Bernard
TI Effect of hepatocyte growth factor on gene expression of extracellular
   matrix during wound healing of the injured rat vocal fold
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE extracellular matrix; hepatocyte growth factor; hyaluronan synthase;
   procollagen; transforming growth factor-beta 1; vocal fold wound healing
ID CANINE MODEL; INFLAMMATORY RESPONSE; SCAR; HYALURONAN; COLLAGEN;
   INJECTION; HGF
AB Objectives: We performed a prospective, sham-controlled animal study to investigate the effects of hepatocyte growth factor (HGF) manipulation of the extracellular matrix on vocal fold gene expression during acute injury.
   Methods: Bilateral vocal fold wounds were created in 40 rats. The rats were randomly assigned to I of 2 groups (sham treatment or HGF treatment) and received treatment of the injured area at the time of wounding and on alternate post-treatment days. The injured vocal fold specimens were harvested on post-treatment days 1, 3, 7, and 14. We used real-time reverse transcription polymerase chain reaction to quantify messenger RNA expression of transforming growth factor (TGF)-beta 1, procollagen types I and III, hyaluronan synthase (HAS)-1, HAS-2, and HAS-3.
   Results: A multivariate analysis of variance revealed a significant interaction between treatment group and post-treatment day for TGF-beta 1, procollagen type I, procollagen type III, and HAS-2. Post hoc testing revealed significantly lower expression of procollagen type III and significantly higher expression of HAS-2 on post-treatment day 14 in the HGF treatment group than in the sham treatment group.
   Conclusions: Results provide evidence of HGF treatment effects on procollagen type III and HAS-2 gene expression pathways.
C1 [Ohno, Tsunehisa; French, Lesley C.; Ossoff, Robert H.; Rousseau, Bernard] Vanderbilt Univ, Dept Otolaryngol, Bill Wilkerson Ctr Otolaryngol & Commun Sci, Nashville, TN 37232 USA.
   [Hirano, Shigeru] Kyoto Univ, Dept Otolaryngol Head & Neck Surg, Grad Sch Med, Kyoto, Japan.
RP Rousseau, B (reprint author), Vanderbilt Univ, Dept Otolaryngol, Bill Wilkerson Ctr Otolaryngol & Commun Sci, 1313 21st Ave S,Room 602, Nashville, TN 37232 USA.
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NR 30
TC 19
Z9 20
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD SEP
PY 2008
VL 117
IS 9
BP 696
EP 702
PN 1
PG 7
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 352MR
UT WOS:000259501800012
PM 18834074
ER

PT J
AU Jahan-Parwar, B
   Chhetri, DK
   Ye, M
   Hart, S
   Berke, GS
AF Jahan-Parwar, Babak
   Chhetri, Dinesh K.
   Ye, Ming
   Hart, Steven
   Berke, Gerald S.
TI Hylan B gel restores structure and function to laser-ablated canine
   vocal folds
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE hyaluronic acid; hylan B; lamina propria; larynx; laser; tissue
   engineering; voice
ID EXTRACELLULAR-MATRIX; TISSUE-REPAIR; INSUFFICIENCY; BIOMECHANICS;
   REGENERATION; FILMS
AB Objectives: We evaluated cross-linked hyaluronic acid (hylan B gel) as a scaffold for tissue regeneration and mucosal wave restoration in carbon dioxide laser-ablated canine vocal folds.
   Methods: Five beagles underwent stroboscopy before ablation of the left vocal fold with a carbon dioxide laser. Four weeks later, stroboscopy was repeated before and after submucosal injection of hylan B gel into the left vocal fold of 4 animals and of saline solution in 1 animal. Stroboscopy was repeated 12 weeks later, and histologic analysis was performed.
   Results: Four weeks after laser ablation, all animals had soft tissue defects and absence of mucosal waves. Hylan B injection restored mucosal waves, and saline injection did not. Twelve weeks after injection, hylan B-injected larynges had tissue regeneration and mucosal waves, and the saline-injected larynx had neither. Histology showed regenerated lamina propria with residual foci of hylan B in the hylan B-injected larynges and dense submucosal scar in the saline-injected animal.
   Conclusions: Submucosal hylan B gel injection in laser-ablated canine vocal folds restored tissue volume and mucosal waves and facilitated functional tissue regeneration over 12 weeks. Hylan B gel may have utility as a soft tissue scaffold for rehabilitation of phonatory function in vocal folds with lamina propria defects.
C1 [Jahan-Parwar, Babak; Chhetri, Dinesh K.; Ye, Ming; Hart, Steven; Berke, Gerald S.] Univ Calif Los Angeles, Div Head & Neck Surg, Med Ctr, Los Angeles, CA 90095 USA.
RP Berke, GS (reprint author), Univ Calif Los Angeles, Div Head & Neck Surg, Med Ctr, 200 Med Plaza,Suite 550, Los Angeles, CA 90095 USA.
CR Atala A, 2003, BJU INT, V92, P58, DOI 10.1046/j.1464-410X.92.s1.15.x
   BERKE GS, 1987, LARYNGOSCOPE, V97, P871
   Catten M, 1998, OTOLARYNG HEAD NECK, V118, P663, DOI 10.1177/019459989811800516
   Duflo S, 2006, TISSUE ENG, V12, P2171, DOI 10.1089/ten.2006.12.2171
   Gray SD, 1999, LARYNGOSCOPE, V109, P845, DOI 10.1097/00005537-199906000-00001
   Hallen L, 1999, ACTA OTO-LARYNGOL, V119, P107
   Hallen L, 1998, LARYNGOSCOPE, V108, P393, DOI 10.1097/00005537-199803000-00015
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   Hertegard S, 2003, OTOLARYNG HEAD NECK, V128, P401, DOI 10.1067/mhn.2003.96
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NR 14
TC 7
Z9 7
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD SEP
PY 2008
VL 117
IS 9
BP 703
EP 707
PN 1
PG 5
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 352MR
UT WOS:000259501800013
PM 18834075
ER

PT J
AU de Negreiros, J
   Sampaio, ALL
   Sesana, WE
   Oliveira, CA
AF de Negreiros, Jacinto, Jr.
   Sampaio, Andre L. L.
   Sesana, Wilson E.
   Oliveira, Carlos A.
TI Imaging case study of the month traumatic pneumolabyrinth
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE computed tomography; pneumolabyrinth; temporal bone trauma
ID TEMPORAL BONE-FRACTURE; SIGN
AB Pneumolabyrinth is a condition in which air is present in the vestibule and/or in the cochlea. Air inside the inner ear structures is uncommon, and is not detected even in otic capsule-violating fractures or in transverse fractures of the temporal bone. It is rarely described in the literature. We present a longitudinal computed tomography (CT) study of a significant pneumolabyrinth due to temporal bone trauma in a 31-year-old man. Routine CT of the cranium performed 3 hours after the accident showed air inside the vestibule (pneumolabyrinth). Two days later, a new CT study was performed. The air in the vestibule was partially resorbed. There was opacity over the oval window niche and the promontory. Thirteen months after the initial head trauma, another CT examination showed a fracture line running from the vestibule to the posterior wall of the petrous bone. The patient had profound sensorineural hearing loss after the trauma, and the pneumolabyrinth cleared over a few months. Surgical treatment was not indicated.
C1 [de Negreiros, Jacinto, Jr.] Univ Brasilia, Sch Med, Dept Otolaryngol, Hosp Santa Luzia, BR-70910900 Brasilia, DF, Brazil.
   [Sesana, Wilson E.] Hosp Brasilia, Dept Radiol, Brasilia, DF, Brazil.
RP Sampaio, ALL (reprint author), SQN 205,B1 B,Apt 506, BR-70843020 Asa Norte Brasilia, DF, Brazil.
CR Gross M, 2003, INT J PEDIATR OTORHI, V67, P553, DOI 10.1016/S0165-5876(03)00013-2
   ISAACSON JE, 1995, ANN OTO RHINOL LARYN, V104, P974
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NR 9
TC 2
Z9 2
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD SEP
PY 2008
VL 117
IS 9
BP 708
EP 710
PN 1
PG 3
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 352MR
UT WOS:000259501800014
PM 18834076
ER

PT J
AU Stepp, CE
   Heaton, JT
   Hillman, RE
AF Stepp, Cara E.
   Heaton, James T.
   Hillman, Robert E.
TI Post-laryngectomy speech respiration patterns
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE alaryngeal speech; breathing; electrolarynx; inductance plethysmography;
   tracheoesophageal speech
ID VERTICAL-BAR PRODUCTION; TOTAL LARYNGECTOMY; ELECTROMYOGRAPHIC ACTIVITY;
   BREATHING PATTERNS; ELECTROLARYNX; REHABILITATION; COMMUNICATION;
   VARIABILITY; DESIGN
AB Objectives: The goal of this study was to determine whether speech breathing changes over time in laryngectomy patients who use an electrolarynx, to explore the potential of using respiratory signals to control an artificial voice source.
   Methods: Respiratory patterns during serial speech tasks (counting, days of the week) with an electrolarynx were prospectively studied by inductance plethysmography in 6 individuals across their first I to 2 years after total laryngectomy, as well as in an additional 8 individuals who had had a laryngectomy at least I year earlier.
   Results: In contrast to normal speech that is only produced during exhalation, all individuals were found to engage in inhalation during speech production, and those studied longitudinally displayed increased occurrences of inhalation during speech production with time after laryngectomy. These trends appear to be stronger for individuals who used an electrolarynx as their primary means of oral communication rather than tracheoesophageal speech, possibly because of continued dependence on respiratory support for the production of tracheoesophageal speech.
   Conclusions: Our results indicate that there are post-laryngectomy changes in the speech breathing behaviors of electrolarynx users. This has implications for designing improved electrolarynx communication systems, which could use signals derived from respiratory function as one of many potential physiologically based sources for more natural control of electrolarynx speech.
C1 [Stepp, Cara E.; Heaton, James T.; Hillman, Robert E.] Massachusetts Gen Hosp, Ctr Laryngeal Surg & Voice Rehabil, Boston, MA 02114 USA.
   [Stepp, Cara E.] Harvard MIT, Div Hlth Sci & Technol, Boston, MA USA.
   [Heaton, James T.; Hillman, Robert E.] Harvard Univ, Sch Med, Dept Surg, Boston, MA 02115 USA.
RP Heaton, JT (reprint author), MGH Voice Ctr, 1 Bowdoin Sq,11th Floor, Boston, MA 02114 USA.
FU National Institute on Deafness and Other Communication Disorders
   [R01-DC006449]; US Department of Veterans Affairs Rehabilitation
   Research and Development [V523P-6820]
FX From the Center for Laryngeal Surgery and Voice Rehabilitation,
   Massachusetts General Hospital (all authors), the Division of Health
   Sciences and Technology, Harvard-MIT (Stepp), and the Department of
   Surgery, Harvard Medical School (Heaton, Hillman), Boston,
   Massachusetts. This research was supported by National Institute on
   Deafness and Other Communication Disorders grant R01-DC006449 and US
   Department of Veterans Affairs Rehabilitation Research and Development
   Grant V523P-6820, both awarded to Dr Hillman.
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NR 27
TC 2
Z9 2
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD AUG
PY 2008
VL 117
IS 8
BP 557
EP 563
PG 7
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 338PC
UT WOS:000258518900001
PM 18771069
ER

PT J
AU Hamzany, Y
   Hadar, T
   Feinmesser, R
   Guttman, D
   Shvero, J
AF Hamzany, Yaniv
   Hadar, Tuvia
   Feinmesser, Raphael
   Guttman, Dan
   Shvero, Jacob
TI Laryngeal carcinoma in nonsmoking patients
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT Israel Annual Otolaryngology Meeting
CY MAR 07-10, 2007
CL Eilat, ISRAEL
DE laryngeal carcinoma; nonsmoker; past smoker; survival
ID SQUAMOUS-CELL CARCINOMA; GASTROESOPHAGEAL-REFLUX; HUMAN-PAPILLOMAVIRUS;
   GLOTTIC LARYNX; NECK-CANCER; ORAL-CAVITY; ALCOHOL; TOBACCO; SMOKING;
   RISK
AB Objectives: Smoking is a known risk factor for laryngeal carcinoma. We sought to describe the clinicopathologic characteristics and outcomes of nonsmoking patients with laryngeal carcinoma.
   Methods: Of 1,443 patients treated for laryngeal carcinoma between 1960 and 2006, 55 (3.8%) were nonsmokers: 40 (73%) had never smoked and 15 (27%) had stopped smoking 12 years or more before diagnosis. Patient characteristics and outcomes were reviewed.
   Results: The study group consisted of 87% men; the mean age at diagnosis was 67 years. All lesions but one were located in the glottis. The 5-year survival rate for the whole group was 85%. Most tumors were detected early. Of 38 patients (69%) with stage T1 disease, there was no significant difference in prognostic features between those who had never smoked and those who had smoked in the past.
   Conclusions: Fewer than 5% of patients with laryngeal carcinoma were nonsmokers. Like smokers, this subgroup was characterized by a male predominance and an approximate age at diagnosis in the seventh decade. Unlike smokers, nonsmokers show a greater predilection for glottic rather than supraglottic disease. There was no difference in prognosis between smokers and nonsmokers, regardless of whether they had smoked in the past.
C1 [Hamzany, Yaniv] Rabin Med Ctr, Dept Otolaryngol Head & Neck Surg, IL-49100 Petah Tiqwa, Israel.
   Tel Aviv Univ, Sackler Fac Med, IL-69978 Tel Aviv, Israel.
RP Hamzany, Y (reprint author), Rabin Med Ctr, Dept Otolaryngol Head & Neck Surg, Beilinson Campus, IL-49100 Petah Tiqwa, Israel.
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NR 37
TC 3
Z9 4
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD AUG
PY 2008
VL 117
IS 8
BP 564
EP 568
PG 5
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 338PC
UT WOS:000258518900002
PM 18771070
ER

PT J
AU Gristwood, RE
   Bedson, J
AF Gristwood, Ronald Edward
   Bedson, Janet
TI Observations on bilateral symmetry of the stapedial footplate lesion and
   narrowing of the oval window niche in otosclerosis
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE bilateral otosclerosis; bilateral symmetry; oval window exostosis;
   prediction; stapes footplate involvement
ID PISTON
AB Objectives: We consider whether patients with bilateral otosclerosis who have surgery on their second ear show symmetry in the degree of severity of their footplate otosclerosis.
   Methods: The severity of the stapedial otosclerotic lesion and the degree of narrowing of the oval window niche by exostoses were recorded for each ear of 269 patients who elected to undergo operation on the second ear. The severities and similarities of the otosclerotic lesion affecting the oval window niche were compared between the ears.
   Results: The majority of oval window niches were normal in width in both ears. A niche narrowed to less than 0.8 mm in diameter was rare and tended to affect both ears (5.6% first ears and 5.95% second ears; chi(2) = 134.6 on 4 df, p < .0001). The degree of footplate otosclerosis was classified and amalgamated into 3 broad categories: minor (47.2%), moderate (21.6%), and severe (31.2%). A high degree of bilateral symmetry of the stapedial footplate lesion was found (chi(2) = 162.2 on 4 df, significant at .0001 level).
   Conclusions: The findings at the oval window of the first ear in regard to the severity of otosclerotic involvement of the stapes footplate and narrowing of the niche by exostoses do allow a fair prediction of the pathological findings in the second ear, if that ear is suitable for stapes surgery and the patient elects to have an operation. The surgeon is forewarned of possible difficulties and technical challenges if an operation has been performed on the first ear.
C1 [Gristwood, Ronald Edward; Bedson, Janet] Royal Adelaide Hosp, Dept Otolaryngol, Adelaide, SA 5000, Australia.
RP Gristwood, RE (reprint author), Toynbee Clin, 12 Walter St N, Adelaide, SA 5006, Australia.
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NR 24
TC 2
Z9 2
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD AUG
PY 2008
VL 117
IS 8
BP 569
EP 573
PG 5
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 338PC
UT WOS:000258518900003
PM 18771071
ER

PT J
AU Kos, MP
   David, EFL
   Aalders, IJ
   Smit, CF
   Mahieu, HF
AF Kos, Martijn P.
   David, Eric F. L.
   Aalders, IJke J.
   Smit, C. Frits
   Mahieu, Hans F.
TI Long-term results of laryngeal suspension and upper esophageal sphincter
   myotomy as treatment for life-threatening aspiration
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE aspiration; dysphagia; laryngeal suspension; upper esophageal sphincter
   myotomy
ID INTRACTABLE ASPIRATION; SURGERY; CLOSURE
AB Objectives: We evaluated the long-term results of laryngeal suspension and upper esophageal sphincter (UES) myotomy in patients with life-threatening aspiration.
   Methods: In the period 1995 to 2004, 17 patients with severe aspiration caused by insufficient laryngeal elevation and absent or negligible pharyngeal constrictor muscle activity during deglutition resulting in aspiration pneumonia were surgically treated with a laryngeal suspension procedure and UES myotomy. Preoperative and postoperative video-fluoroscopy was performed to assess swallowing and aspiration.
   Results: In 9 of the 17 patients, long-term (more than 1 year) full oral intake without aspiration was achieved. Three other patients demonstrated improvement of deglutition with partial restoration of oral intake with adjusted food consistency, but remained partly dependent on gastrostomy feeding for adequate nutrition. Two patients no longer had cases of aspiration pneumonia, but were unable to achieve even modified oral intake. Three patients finally underwent total laryngectomy - 2 of them after initial successful full oral intake without aspiration but with recurrent aspiration as a result of progression of neuromuscular disease. None of the patients succumbed to aspiration pneumonia.
   Conclusions: In most of our patients, life-threatening aspiration was successfully treated by UES myotomy and laryngeal suspension with restoration of oral intake.
C1 [Kos, Martijn P.; Aalders, IJke J.; Smit, C. Frits; Mahieu, Hans F.] Free Univ Med Ctr, Dept Otolaryngol Head & Neck Surg, NL-1007 MB Amsterdam, Netherlands.
   [David, Eric F. L.] Free Univ Med Ctr, Dept Radiol, NL-1007 MB Amsterdam, Netherlands.
   [Mahieu, Hans F.] Meander Med Ctr, Dept Otolaryngol, Amersfoort, Netherlands.
RP Kos, MP (reprint author), Free Univ Med Ctr, Dept Otolaryngol Head & Neck Surg, POB 7057, NL-1007 MB Amsterdam, Netherlands.
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   MEITELES LZ, 1993, LARYNGOSCOPE, V103, P1395
   MONTGOMERY WW, 1975, ARCH OTOLARYNGOL, V101, P679
   Recio SA, 1996, INT CONGR SER, V1112, P243
   SASAKI CT, 1980, ARCH OTOLARYNGOL, V106, P422
   TIWARI R, 1993, ARCH OTOLARYNGOL, V119, P945
NR 21
TC 4
Z9 4
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD AUG
PY 2008
VL 117
IS 8
BP 574
EP 580
PG 7
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 338PC
UT WOS:000258518900004
PM 18771072
ER

PT J
AU Pinto, FR
   de Magalhaes, RP
   Capelli, FD
   Brandao, LG
   Kanda, JL
AF Pinto, Fabio Roberto
   de Magalhaes, Roberto Pereira
   Capelli, Fabio de Aquino
   Brandao, Lenine Garcia
   Kanda, Jossi Ledo
TI Pedicled temporoparietal galeal flap for reconstruction of intraoral
   defects
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE mouth; oropharynx; surgical flap; temporal artery
ID NECK RECONSTRUCTION; FASCIAL FLAP; EAR RECONSTRUCTION; HEAD; EXPERIENCE;
   CANCER
AB Objectives: In this report we aim to describe the surgical technique required to utilize the pedicled temporoparietal galeal flap for repair of selected intraoral defects and to report our experience with this type of reconstructive procedure.
   Methods: The charts of 6 consecutive patients submitted to reconstruction of intraoral defects using the pedicled temporoparietal galeal flap were reviewed. All of the defects were located in the posterior oral cavity and oropharynx. After resection of the oral cancer, the temporoparietal galeal flap, based on the superficial temporal vessels, was raised and transposed to the mouth through a tunnel under the zygomatic arch. The oral defect was repaired, and no skin graft was applied over the flap.
   Results: There were no flap losses, and the reconstructive goal was achieved in all cases. The patients' deglutition and phonation abilities were restored, and the donor site scars were well hidden by hair growth.
   Conclusions: The pedicled temporoparietal galeal flap is another option for selected cases of reconstruction of intraoral defects - mainly those located in the posterior oral cavity and oropharynx, in which thin and pliable tissues are usually required.
C1 [Pinto, Fabio Roberto; Capelli, Fabio de Aquino; Kanda, Jossi Ledo] Hosp Ensino, Fac Med ABC, Dept Head & Neck Surg, Sao Paulo, Brazil.
   [de Magalhaes, Roberto Pereira; Brandao, Lenine Garcia] Brazilian Inst Canc Control, Dept Head & Neck Surg, Sao Paulo, Brazil.
RP Pinto, FR (reprint author), Rua Carlos Tiago Pereira 520, BR-04150080 Sao Paulo, Brazil.
RI Brandao, Lenine/J-5334-2013; PTMS, RNEM/C-1589-2014
CR Avelar J M, 1981, Ann Plast Surg, V6, P464, DOI 10.1097/00000637-198106000-00008
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NR 23
TC 9
Z9 9
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD AUG
PY 2008
VL 117
IS 8
BP 581
EP 586
PG 6
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 338PC
UT WOS:000258518900005
PM 18771073
ER

PT J
AU Pham, AM
   Rees, CJ
   Belafsky, PC
AF Pham, Annette M.
   Rees, Catherine J.
   Belafsky, Peter C.
TI Endoscopic removal of a giant fibrovascular polyp of the esophagus
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT 87th Annual Meeting of the American-Broncho-Esophagological-Association
CY APR 26-27, 2007
CL San Diego, CA
SP Amer Broncho Esophagol Assoc
DE benign tumor; endoscopic management; esophageal mass; esophagus; giant
   fibrovascular polyp; polyp
ID HYPOPHARYNX
AB Objectives: Giant fibrovascular polyps of the esophagus are rare benign tumors originating from the proximal esophagus. These pedunculated lesions can grow to "giant" proportions. Asphyxiation from aspiration of the regurgitated polyp is a well-described cause of death. Traditional excision has involved a transcervical vertical esophagotomy. This report describes the successful endoscopic removal of a giant fibrovascular polyp of the esophagus.
   Results: A 63-year-old man with dwarfism and obstructive sleep apnea was referred for evaluation of an esophageal mass that was intermittently regurgitated into the hypopharynx. Office esophagoscopy demonstrated a 10-cm giant fibrovascular polyp originating just below the cricoid cartilage. During endoscopic removal, the base of the lesion was exposed with a Weerda bivalved laryngoscope. Bipolar cautery combined with a snare was used to transect the base with excellent hemostasis. No esophageal leak was noted on an esophagogram on postoperative day 3. The patient then resumed a liquid diet and was discharged home, resuming a regular diet within a week.
   Conclusions: Giant fibrovascular polyps of the esophagus are life-threatening because of potential airway obstruction. This report describes the successful endoscopic removal of a giant fibrovascular polyp, avoiding the potential morbidity associated with a transcervical vertical esophagotomy.
C1 [Pham, Annette M.; Belafsky, Peter C.] Univ Calif Davis, Sch Med, Dept Otolaryngol Head & Neck Surg, Ctr Voice & Swallowing, Sacramento, CA 95817 USA.
   [Rees, Catherine J.] Wake Forest Univ, Sch Med, Ctr Voice Swallowing Disorders, Winston Salem, NC 27109 USA.
RP Belafsky, PC (reprint author), Univ Calif Davis, Sch Med, Dept Otolaryngol Head & Neck Surg, Ctr Voice & Swallowing, 2521 Stockton Blvd,Ste 7200, Sacramento, CA 95817 USA.
CR Belafsky P, 1999, SOUTHERN MED J, V92, P428
   Carrick C, 2005, AM J FOREN MED PATH, V26, P275, DOI 10.1097/01.paf.0000178098.33597.de
   Fries MR, 2003, ARCH PATHOL LAB MED, V127, P485
   Hoseok I, 2006, J KOREAN MED SCI, V21, P749
   Luthen R, 2006, EUR J GASTROEN HEPAT, V18, P1005
   Paik HC, 2001, YONSEI MED J, V42, P264
   Sargent RL, 2006, ARCH PATHOL LAB MED, V130, P725
   Schuhmacher C, 2000, DIS ESOPHAGUS, V13, P324, DOI 10.1046/j.1442-2050.2000.00141.x
   Seshul MJ, 1998, ANN OTO RHINOL LARYN, V107, P797
   Zevallos JP, 2005, LARYNGOSCOPE, V115, P876, DOI 10.1097/01.MLG.0000158351.00602.86
NR 10
TC 8
Z9 9
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD AUG
PY 2008
VL 117
IS 8
BP 587
EP 590
PG 4
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 338PC
UT WOS:000258518900006
PM 18771074
ER

PT J
AU Sharma, A
   Wayne, S
   Nikiforova, MN
   Johnson, JT
   Walvekar, RR
AF Sharma, Arun
   Wayne, Sigrid
   Nikiforova, Marina N.
   Johnson, Jonas T.
   Walvekar, Rohan R.
TI Two sites of head and neck squamous cell carcinoma: Utility of loss of
   heterozygosity
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE distant metastasis; laryngeal cancer; loss of heterozygosity; mandible
ID METASTASES; TUMORS
AB Objectives: The prevalence of distant metastasis and second primary tumors is increasing with improved locoregional control in patients with head and neck squamous cell carcinoma. Traditionally, clinicopathologic evidence has been the gold standard used to distinguish distant metastasis from second primary tumors. We report a case in which loss of heterozygosity testing was used to clarify the clonal relationship between the 2 sites of head and neck squamous cell carcinoma.
   Methods: A patient with squamous cell carcinoma in the larynx and mandible underwent loss of heterozygosity testing.
   Results: The loss of heterozygosity testing confirmed that the mandibular cancer was a metastatic presentation of the laryngeal squamous cell carcinoma.
   Conclusions: We conclude that loss of heterozygosity testing can be useful in differentiating distant metastasis from second primary cancers in patients with 2 sites of head and neck squamous cell carcinoma, consequently providing important prognostic and staging information.
C1 [Sharma, Arun; Johnson, Jonas T.; Walvekar, Rohan R.] Univ Pittsburgh, Med Ctr, Dept Otolaryngol Head & Neck Surg, Pittsburgh, PA USA.
   [Wayne, Sigrid; Nikiforova, Marina N.] Univ Pittsburgh, Med Ctr, Dept Pathol, Pittsburgh, PA USA.
RP Walvekar, RR (reprint author), Univ Pittsburgh, Dept Otolaryngol Head Neck Surg, Suite 500 EEI, Pittsburgh, PA 15213 USA.
CR AJCC cancer staging manual, 2002, AJCC CANC STAG MAN
   Brinkmann D, 2004, J NATL CANCER I, V96, P1441, DOI 10.1093/jnci/djh272
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   Geurts TW, 2005, CLIN CANCER RES, V11, P6608, DOI 10.1158/1078-0432.CCR-05-0257
   Gollin SM, 2001, HEAD NECK-J SCI SPEC, V23, P238, DOI 10.1002/1097-0347(200103)23:3<238::AID-HED1025>3.0.CO;2-H
   Leong PP, 1998, J NATL CANCER I, V90, P972, DOI 10.1093/jnci/90.13.972
   Nikolaou AC, 2000, LARYNGOSCOPE, V110, P58, DOI 10.1097/00005537-200001000-00012
   Pietropaoli MP, 2000, J SURG ONCOL, V75, P136, DOI 10.1002/1096-9098(200010)75:2<136::AID-JSO11>3.0.CO;2-D
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   Spector JG, 2001, LARYNGOSCOPE, V111, P1079, DOI 10.1097/00005537-200106000-00028
   Taneja C, 2002, ARCH OTOLARYNGOL, V128, P324
   van der Waal RIF, 2003, BRIT J ORAL MAX SURG, V41, P3, DOI 10.1016/S0266-4356(02)00301-7
NR 13
TC 1
Z9 1
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD AUG
PY 2008
VL 117
IS 8
BP 591
EP 593
PG 3
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 338PC
UT WOS:000258518900007
PM 18771075
ER

PT J
AU Paniello, RC
   Martin-Bredahl, KJ
   Henkener, LJ
   Riew, KD
AF Paniello, Randal C.
   Martin-Bredahl, Katherine J.
   Henkener, Lori J.
   Riew, K. Daniel
TI Preoperative laryngeal nerve screening for revision anterior cervical
   spine procedures
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT 87th Annual Meeting of the American-Broncho-Esophagological-Association
CY APR 26-27, 2007
CL San Diego, CA
SP Amer Broncho Esophagol Assoc
DE cervical spine; complication; preoperative screening; recurrent
   laryngeal nerve; superior laryngeal nerve
ID VOCAL FOLD PARALYSIS; SURGERY; DISKECTOMY; INJURY; FUSION; DYSPHAGIA;
   MOTION; RISK
AB Objectives: Anterior cervical spine procedures carry an inherent risk of recurrent laryngeal nerve (RLN) injury. Patients with persistent RLN paresis may be asymptomatic because of compensation from the opposite side. If such patients undergo an opposite-side anterior approach for revision surgery, they are at risk for a second RLN injury, creating the potential for bilateral vocal fold paresis and possible need for tracheotomy. A program of routine screening for laryngeal paresis was implemented for these patients. This retrospective study reviews the results of this screening process.
   Methods: Patients referred for preoperative laryngeal nerve screening were identified. Their charts were reviewed for the results of the videolaryngoscopic examination, and for any recommendations made based on the findings. Relevant history and other physical findings were recorded.
   Results: Fifty screening laryngeal examinations were performed in 47 patients, of whom 31 (66%) had previously undergone a single anterior cervical approach procedure, and 16 (34%) had undergone more than one. Thirteen of the examinations (26%) revealed abnormal laryngeal findings, including paresis or paralysis in 11 cases (22%), of which 5 were asymptomatic. The findings resulted in a recommendation of a cervical approach from the already-involved side. None of the revision procedures resulted in bilateral vocal fold paralysis. The risk of laryngeal nerve injury appears to increase as higher cervical levels are approached.
   Conclusions: Minimally symptomatic injuries of the laryngeal nerves from prior neck surgery create a potential serious risk of bilateral vocal fold paralysis with subsequent procedures. Preoperative laryngeal screening is a simple and effective method for reducing this risk.
C1 [Paniello, Randal C.; Martin-Bredahl, Katherine J.; Henkener, Lori J.] Washington Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, St Louis, MO 63110 USA.
   [Riew, K. Daniel] Washington Univ, Sch Med, Dept Orthoped Surg, St Louis, MO 63110 USA.
RP Paniello, RC (reprint author), Washington Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, 660 S Euclid Ave,Campus Box 8115, St Louis, MO 63110 USA.
CR Baron EM, 2003, ANN OTO RHINOL LARYN, V112, P921
   Bazaz R, 2002, SPINE, V27, P2453, DOI 10.1097/01.BRS.0000031407.52778.4B
   Beutler WJ, 2001, SPINE, V26, P1337, DOI 10.1097/00007632-200106150-00014
   Ebraheim NA, 1997, SPINE, V22, P2664, DOI 10.1097/00007632-199711150-00015
   Farrag TY, 2006, LARYNGOSCOPE, V116, P235, DOI 10.1097/01.mlg.0000191472.02720.1f
   Jung A, 2005, J NEUROSURG-SPINE, V2, P123, DOI 10.3171/spi.2005.2.2.0123
   Kilburg C, 2006, J NEUROSURG-SPINE, V4, P273, DOI 10.3171/spi.2006.4.4.273
   Kriskovich MD, 2000, LARYNGOSCOPE, V110, P1467, DOI 10.1097/00005537-200009000-00011
   Lee MJ, 2007, SPINE J, V7, P141, DOI 10.1016/j.spinee.2006.02.024
   Manski TJ, 1998, J NEUROSURG, V89, P839, DOI 10.3171/jns.1998.89.5.0839
   Melamed Hooman, 2002, Spine (Phila Pa 1976), V27, pE83, DOI 10.1097/00007632-200202150-00005
   Morpeth JF, 2000, LARYNGOSCOPE, V110, P43, DOI 10.1097/00005537-200001000-00009
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   Weisberg NK, 1997, OTOLARYNG HEAD NECK, V116, P317, DOI 10.1016/S0194-5998(97)70266-3
NR 14
TC 1
Z9 1
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD AUG
PY 2008
VL 117
IS 8
BP 594
EP 597
PG 4
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 338PC
UT WOS:000258518900008
PM 18771076
ER

PT J
AU Rousseau, B
   Ge, PJ
   Ohno, T
   French, LC
   Thibeault, SL
AF Rousseau, Bernard
   Ge, Ping Jiang
   Ohno, Tsunehisa
   French, Lesley C.
   Thibeault, Susan L.
TI Extracellular matrix gene expression after vocal fold injury in a rabbit
   model
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT Meeting of the American-Laryngological-Association
CY MAY 01-02, 2008
CL Orlando, FL
SP Amer Laryngol Assoc
DE gene expression; injury; phonation; rabbit model; scar; vocal fold
ID DIFFERENTIAL EXPRESSION; SCAR; METALLOPROTEINASES; FIBRONECTIN;
   HYALURONAN; INHIBITORS; PROTEIN
AB Objectives: We determined the expression of matrix metalloproteinase (MMP)-1, MMP-9, collagen types I and III, and fibronectin from rabbit vocal folds after injury.
   Methods: Thirty rabbits were involved in this study. Five animals were assigned to each time period. Noninjured vocal fold specimens were collected as a control. Gene expression was analyzed at 2, 4, 8, 24, 48, and 72 hours after injury by use of real-time polymerase chain reaction.
   Results: Compared to 2 hours after injury, MMP-1 expression was increased at 4, 8, 24, 48, and 72 hours. Compared to 4 hours, MMP-1 expression was increased at 8, 24, 48, and 72 hours. Compared to the control specimens, MMP-9 expression was increased at 4, 8, 24, 48, and 72 hours. Compared to 2 hours, MMP-9 expression was increased at 4, 8, 24, 48, and 72 hours. Compared to 2 and 4 hours, collagen type I expression was increased at 72 hours. Collagen type III expression was increased at 72 hours compared to 2, 4, and 8 hours. Compared to 2 hours, fibronectin expression was increased at 24, 48, and 72 hours.
   Conclusions: Results revealed time-dependent changes in expression of MMP-1, MMP-9, collagen types I and III, and fibronectin from rabbit vocal folds after injury. Future experiments are planned to investigate the effects of phonation on expression of these genes after injury.
C1 [Rousseau, Bernard; Ohno, Tsunehisa; French, Lesley C.] Vanderbilt Univ, Dept Otolaryngol, Bill Wilkerson Ctr Otolaryngol & Commun Sci, Nashville, TN 37232 USA.
   [Thibeault, Susan L.] Univ Wisconsin, Dept Surg, Div Otolaryngol Head & Neck Surg, Madison, WI USA.
RP Rousseau, B (reprint author), Vanderbilt Univ, Dept Otolaryngol, Bill Wilkerson Ctr Otolaryngol & Commun Sci, 1313 21st Ave S,Room 602, Nashville, TN 37232 USA.
CR BIRKEDALHANSEN H, 1995, CURR OPIN CELL BIOL, V7, P728, DOI 10.1016/0955-0674(95)80116-2
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   Hirano S, 2004, LARYNGOSCOPE, V114, P548, DOI 10.1097/00005537-200403000-00030
   Hirschi SD, 2002, J VOICE, V16, P310, DOI 10.1016/S0892-1997(02)00102-9
   Lim XH, 2006, ANN OTO RHINOL LARYN, V115, P921
   Madlener M, 1998, ARCH DERMATOL RES, V290, pS24, DOI 10.1007/PL00007450
   Pardo A, 2005, INT J BIOCHEM CELL B, V37, P283, DOI 10.1016/j.biocel.2004.06.017
   Peled ZM, 2000, CLIN PLAST SURG, V27, P489
   Rousseau B, 2004, ANN OTO RHINOL LARYN, V113, P767
   Rousseau B, 2003, LARYNGOSCOPE, V113, P620, DOI 10.1097/00005537-200304000-00007
   Rousseau B, 2004, J VOICE, V18, P116, DOI 10.1016/j.jvoice.2003.06.001
   Rousseau B, 2008, OTOLARYNG HEAD NECK, V138, P62, DOI 10.1016/j.otohns.2007.10.024
   Soo C, 2000, PLAST RECONSTR SURG, V106, P236, DOI 10.1097/00006534-200007000-00066
   Stephens P, 2002, J Wound Care, V11, P253
   Tateya T, 2006, ANN OTO RHINOL LARYN, V115, P285
   Thibeault SL, 2004, LARYNGOSCOPE, V114, P760, DOI 10.1097/00005537-200404000-00031
   Thibeault SL, 2002, J VOICE, V16, P96, DOI 10.1016/S0892-1997(02)00078-4
   Thibeault SL, 2002, ANN OTO RHINOL LARYN, V111, P302
   Thibeault SL, 2003, J VOICE, V17, P377, DOI 10.1067/S0892-1997(03)00064-X
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   Welham NV, 2008, ANN OTO RHINOL LARYN, V117, P145
NR 25
TC 13
Z9 13
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD AUG
PY 2008
VL 117
IS 8
BP 598
EP 603
PG 6
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 338PC
UT WOS:000258518900009
PM 18771077
ER

PT J
AU Tessema, B
   Pitman, MJ
   Roark, RM
   Berzofsky, C
   Sharma, S
   Schaefer, SD
AF Tessema, Belachew
   Pitman, Michael J.
   Roark, Rick M.
   Berzofsky, Craig
   Sharma, Sansar
   Schaefer, Steven D.
TI Evaluation of functional recovery of recurrent laryngeal nerve using
   transoral laryngeal bipolar electromyography: A rat model
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT 87th Annual Meeting of the American-Broncho-Esophagological-Association
CY APR 26-27, 2007
CL San Diego, CA
SP Amer Broncho Esophagol Assoc
DE animal model; crush injury; rat; recurrent laryngeal nerve injury;
   transoral electromyography
ID CRICOARYTENOID MUSCLE; ANEURYSM CLIP; REINNERVATION; RECORDINGS;
   INJURIES; CRUSH; SIZE
AB Objectives: We developed a standardized method of minimally invasive transoral laryngeal (ToL) bipolar electromyography (EMG) for evaluation of recurrent laryngeal nerve (RLN) recovery after a controlled crush injury in a rat model.
   Methods: Ten 200- to 250-g Sprague-Dawley rats underwent a controlled crush injury to the left RLN performed with 60 seconds of use of a calibrated aneurysm clamp with a closing force of 0.61 N. Serial ToL bipolar EMG was performed on adductor muscles and the posterior criocoarytenoid muscle during spontaneous vocal fold motion under anesthesia. Each animal underwent ToL EMG immediately after surgery and 1, 3, and 6 weeks after surgery.
   Results: The EMG signals showed normal motor unit potentials and recruitment patterns 3 weeks after crush injury. Endoscopic evaluation of vocal fold mobility yielded consistently normal findings 6 weeks after crush injury.
   Conclusions: We have developed a standardized method of crush injury to the rat RLN model and a minimally invasive transoral bipolar spontaneous EMG technique to serially evaluate and follow nerve injury and recovery in rats. This model is intended to simulate intraoperative RLN injury, to elucidate the electrophysioiogical events that occur during nerve recovery, and to form the basis for studying agents to enhance such recovery.
C1 [Tessema, Belachew; Pitman, Michael J.; Roark, Rick M.; Schaefer, Steven D.] New York Eye & Ear Infirm, Dept Otolaryngol, New York, NY 10003 USA.
   [Berzofsky, Craig; Sharma, Sansar] New York Med Coll, Dept Cell Biol, Valhalla, NY 10595 USA.
RP Schaefer, SD (reprint author), New York Eye & Ear Infirm, Dept Otolaryngol, 310 E 14th St,6th Floor, New York, NY 10003 USA.
CR Berkowitz RG, 1997, ANN OTO RHINOL LARYN, V106, P897
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NR 19
TC 15
Z9 15
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD AUG
PY 2008
VL 117
IS 8
BP 604
EP 608
PG 5
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 338PC
UT WOS:000258518900010
PM 18771078
ER

PT J
AU Omori, K
   Nakamura, T
   Kanemaru, S
   Magrufov, A
   Yamashita, M
   Shimizu, Y
AF Omori, Koichi
   Nakamura, Tatsuo
   Kanemaru, Shinichi
   Magrufov, Akhmar
   Yamashita, Masaru
   Shimizu, Yasuhiko
TI In situ tissue engineering of the cricoid and trachea in a canine model
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE cricoid cartilage; in situ tissue engineering; regeneration; trachea
ID COLLAGEN SPONGE; GLOTTIC RECONSTRUCTION; SUBGLOTTIC STENOSIS;
   HEMILARYNGECTOMY; REPLACEMENT; PROSTHESIS; REPAIR; FLAP
AB Objectives: The purpose of the current study was to demonstrate the efficacy of in situ tissue engineering of the cricoid and trachea in a canine model.
   Methods: Marlex mesh tube reinforced with polypropylene threads and covered by collagen sponge was used as a tissue scaffold for airway regeneration in 9 beagle dogs. The anterior half of the cricoid cartilage was resected in 5 dogs, whereas the cricoid cartilage and cervical trachea were simultaneously resected in 4 dogs. The tissue scaffold was implanted into the resultant defect.
   Results: Endoscopic examination showed no airway obstruction for a postoperative period of 3 to 40 months in all dogs. Granulation tissue was observed in 2 dogs, and slight mesh exposure in 1 dog, although all were asymptomatic. Light microscopy and electron microscopy showed the endolaryngeal and endotracheal lumen to be covered by ciliated epithelium. According to strain-force measurement, the framework was firmly supported by regenerated tissue, as well as the normal cricoid and trachea.
   Conclusions: Our current tissue scaffold provides a rigid framework for the airway, and the collagen coating invites tissue regrowth around the tube. This study presents the possibility of successful reconstruction of the cricoid and trachea with epithelial regeneration by means of in situ tissue engineering.
C1 [Omori, Koichi] Fukushima Med Univ, Sch Med, Dept Otolaryngol, Fukushima 9601295, Japan.
   [Nakamura, Tatsuo; Shimizu, Yasuhiko] Kyoto Univ, Inst Frontier Med Sci, Field Clin Applicat, Dept Bioartificial Organs, Kyoto, Japan.
   [Kanemaru, Shinichi; Magrufov, Akhmar; Yamashita, Masaru] Kyoto Univ, Postgrad Med Sch, Dept Otolaryngol Head & Neck Surg, Kyoto, Japan.
RP Omori, K (reprint author), Fukushima Med Univ, Sch Med, Dept Otolaryngol, 1 Hikarigaoka, Fukushima 9601295, Japan.
RI Yamashita, Masaru/B-2411-2009
FU Japan Society for the Promotion of Science; Ministry of Health, Labor
   and Welfare, Japan, and by Fukushima Medical University
FX From the Department of Otolaryngology, Fukushima Medical University,
   School of Medicine, Fukushima City (Omori), and the Department of
   Bioartificial Organs, Field of Clinical Application, Institute for
   Frontier Medical Sciences (Nakamura, Shimizu), and the Department of
   Otolaryngology-Head and Neck Surgery, Postgraduate School of Medicine
   (Kanemaru, Magrufov, Yamashita), Kyoto University, Kyoto, Japan. This
   study was supported by a Grant-in-Aid for Scientific Research (B) from
   Japan Society for the Promotion of Science, by a Grant of Health and
   Labor Science Research Grants for Research on Human Genome, Tissue
   Engineering from Ministry of Health, Labor and Welfare, Japan, and by
   Fukushima Medical University.
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NR 15
TC 11
Z9 12
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD AUG
PY 2008
VL 117
IS 8
BP 609
EP 613
PG 5
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 338PC
UT WOS:000258518900011
PM 18771079
ER

PT J
AU El-Hakim, H
AF El-Hakim, Hamdy
TI Injection of botulinum toxin into external laryngeal muscles in
   pediatric laryngeal paralysis
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT 22nd Annual Meeting of the American-Society-of-Pediatric-Otolaryngology
CY APR 27-29, 2007
CL San Diego, CA
SP Amer Soc Pediat Otolaryngol
DE botulinum toxin; laryngeal paralysis; pediatrics; treatment
ID VOCAL CORD PARALYSIS; CRICOTHYROID MUSCLE; FOLD PARALYSIS; CHILDREN;
   LATERALIZATION; CONTRACTION; SURGERY; INFANTS; MODEL; CONFIGURATION
AB Objectives: I undertook to demonstrate the effect of injecting botulinum toxin type A (BTA) into cricothyroid, sternothyroid, and stemohyoid muscles in cases of bilateral laryngeal paralysis (BLP). Tracheostomy remains the consistently reproducible and accepted method to salvage the airway obstruction in BLP. The bypass, however, acknowledges the current lack of knowledge and consensus on the pathogenesis.
   Methods: I performed a retrospective chart review of BLP cases treated with BTA in a tertiary care pediatric center. The injections were performed under direct vision through an open transcervical approach. The main outcome measures used were improvement of airway symptoms and endoscopic findings, tracheostomy requirement, and incidence of recovery of function.
   Results: In total, 24 patients with BLP were identified. Over a 2-year period, 7 patients were treated with BTA. Six patients had congenital idiopathic BLP. One of these had trisomy 7. One patient acquired the paralysis after cardiac surgery. No patients required a tracheostomy, except for the infant with trisomy 7. Six patients recovered function completely, and the seventh recovered it partially (range, 4 weeks to 12 months).
   Conclusions: Injection of BTA into external laryngeal muscles may be an alternative to tracheostomy in BLP. It is proposed that the toxin relaxes the glottic aperture by paralyzing the cricothyroid and strap muscles and that it may aid in appropriate reinnervation of the larynx via mechanisms beyond the neuromuscular junction.
C1 [El-Hakim, Hamdy] Pediat Otolaryngol Serv, Subdiv Pediat Surg, Edmonton, AB T6G 2R7, Canada.
   [El-Hakim, Hamdy] Stollery Childrens Hosp, Dept Pediat, Edmonton, AB, Canada.
RP El-Hakim, H (reprint author), Pediat Otolaryngol Serv, Subdiv Pediat Surg, 2C3-57 Walter MacKenzie Hlth Sci Ctr, Edmonton, AB T6G 2R7, Canada.
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NR 37
TC 7
Z9 7
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD AUG
PY 2008
VL 117
IS 8
BP 614
EP 620
PG 7
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 338PC
UT WOS:000258518900012
PM 18771080
ER

PT J
AU Katada, A
   Van Himbergen, D
   Kunibe, I
   Nonaka, S
   Harabuchi, Y
   Huang, S
   Billante, CR
   Zealear, DL
AF Katada, Akihiro
   Van Himbergen, Daniel
   Kunibe, Isamu
   Nonaka, Satoshi
   Harabuchi, Yasuaki
   Huang, Shan
   Billante, Cheryl R.
   Zealear, David L.
TI Evaluation of a deep brain stimulation electrode for laryngeal pacing
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT 22nd Annual Meeting of the American-Society-of-Pediatric-Otolaryngology
CY APR 27-29, 2007
CL San Diego, CA
SP Amer Soc Pediat Otolaryngol
DE denervation; electrical pacing; laryngeal muscle; paralysis; synkinetic
   reinnervation
ID CHRONIC ELECTRICAL-STIMULATION; PARALYZED HUMAN LARYNX; VOCAL FOLD
   IMMOBILITY; SUBTOTAL ARYTENOIDECTOMY; MUSCLE; REANIMATION; PACEMAKER;
   VOICE
AB Objectives: The purpose of the present study was to evaluate the suitability of a deep brain stimulation electrode for laryngeal pacing. Of interest was whether the smaller and more closely spaced channels could provide sufficient channel redundancy, controlled current distribution, and discrete activation of the posterior cricoarytenoid (PCA) muscle.
   Methods: A study was conducted in dogs under differing states of PCA muscle innervation representing complete denervation to complete synkinetic reinnervation. In 3 animals, stimulated glottal opening was assessed in the innervated state and after chemical denervation by pancuronium bromide. In 3 additional dogs, the left side of the larynx was surgically denervated and compared to the innervated, right side to study an anatomic model of clinical paralysis.
   Results: The thresholds were lower and the maximum level of abduction was greater for the innervated state. The stimulated glottal opening equaled that of a spontaneously breathing animal. Abductory responses were obtained across all channels in the array, demonstrating its anatomic and physiological compatibility for this application. In the denervated state, responses were only 20% of that of the innervated state with a pulse duration of 0.5 ms. The response could be enhanced to 40% and 60% by increasing the pulse duration to 1 and 2 ms.
   Conclusions: A deep brain stimulation electrode could effectively reanimate the PCA muscle to a normal level in a case of synkinetic reinnervation and to as much as 60% of the normal level in a case of complete denervation.
C1 [Katada, Akihiro; Van Himbergen, Daniel; Kunibe, Isamu; Huang, Shan; Billante, Cheryl R.; Zealear, David L.] Vanderbilt Univ, Sch Med, Dept Otolaryngol, Nashville, TN 37232 USA.
   [Katada, Akihiro; Kunibe, Isamu; Harabuchi, Yasuaki] Asahikawa Med Coll, Dept Otolaryngol, Asahikawa, Hokkaido 078, Japan.
RP Zealear, DL (reprint author), Vanderbilt Univ, Sch Med, Dept Otolaryngol, Med Ctr N S2100, Nashville, TN 37232 USA.
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NR 19
TC 6
Z9 6
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD AUG
PY 2008
VL 117
IS 8
BP 621
EP 629
PG 9
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 338PC
UT WOS:000258518900013
PM 18771081
ER

PT J
AU Tsuchiya, K
   Komori, M
   Zheng, QY
   Ferrieri, P
   Lin, JZ
AF Tsuchiya, Katsuyuki
   Komori, Masahiro
   Zheng, Qing Yin
   Ferrieri, Patricia
   Lin, Jizhen
TI Interleukin-10 is an essential modulator of mucoid metaplasia in a mouse
   otitis media model
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE interleukin-10 knockout mouse; mucous cell metaplasia; pneumococcal
   middle ear infection
ID NECROSIS-FACTOR-ALPHA; MIDDLE-EAR; EPITHELIAL-CELLS; GENE-EXPRESSION;
   UP-REGULATION; IL-10; INDUCTION; CYTOKINES; RATS; INFLAMMATION
AB Objectives: Inflammatory cytokines are involved in the development of mucous cell metaplasia and hyperplasia (MCM) in otitis media (OM). However, which cytokines play an essential role in the MCM of OM is not clear at the moment.
   Methods: In this study, we hypothesized that interieukin-10 (IL-10) played an indispensable role in the MCM of bacterial OM, and we used IL-10 knockout mice to test this hypothesis.
   Results: In wild-type mice, both Streptococcus pneumoniae and Haemophilus influenzae triggered the development of MCM in the middle ear mucosa. In IL-10 knockout mice, the number of goblet cells and mucin-producing cells in the middle ear was significantly reduced after bacterial middle ear infection compared with that in wild-type mice.
   Conclusions: We conclude that IL-10 plays an essential role in the MCM of bacterial OM. Interleukin-10 is a potential target for the treatment of MCM in OM.
C1 [Tsuchiya, Katsuyuki; Komori, Masahiro; Ferrieri, Patricia; Lin, Jizhen] Univ Minnesota, Sch Med, Otitis Med Res Ctr, Minneapolis, MN 55455 USA.
   [Tsuchiya, Katsuyuki; Komori, Masahiro; Lin, Jizhen] Univ Minnesota, Sch Med, Dept Otolaryngol, Minneapolis, MN 55455 USA.
   [Ferrieri, Patricia] Univ Minnesota, Sch Med, Dept Pediat, Div Infect Dis, Minneapolis, MN 55455 USA.
   [Zheng, Qing Yin] Jackson Lab, Bar Harbor, ME 04609 USA.
RP Lin, JZ (reprint author), 2001 6th St SE,Lions Res Bldg,Room 216, Minneapolis, MN 55455 USA.
RI Zheng, Qing/C-1731-2012
FU National Institutes of Health [R01 DC008165, P30 DC04660, R21 DC009039];
   Institutional Animal Care and Use Committee (IACUC) of the University of
   Minnesota
FX From the University of Minnesota Otitis Media Research Center (Tsuchiya,
   Komori, Ferrieri, Lin), the Department of Otolaryngology (Tsuchiya,
   Komori, Lin), and the Division of Infectious Diseases, Department of
   Pediatrics (Ferrieri), University of Minnesota Medical School,
   Minneapolis, Minnesota, and the Jackson Laboratory, Bar Harbor, Maine
   (Zheng). This study is supported in part by the National Institutes of
   Health grants R01 DC008165 (to J.L.) and P30 DC04660 and R21 DC009039
   (to Q.Y.Z.). This study was performed in accordance with the PHS Policy
   on Humane Care and Use of Laboratory Animals, the NIH Guide for the Care
   and Use of Laboratory Animals, and the Animal Welfare Act (7 U.S.C. et
   seq.); the animal use protocol was approved by the Institutional Animal
   Care and Use Committee (IACUC) of the University of Minnesota.
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NR 31
TC 5
Z9 5
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD AUG
PY 2008
VL 117
IS 8
BP 630
EP 636
PG 7
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 338PC
UT WOS:000258518900014
PM 18771082
ER

PT J
AU Zeitels, SM
   Burns, JA
   Lopez-Guerra, G
   Anderson, RR
   Hillman, RE
AF Zeitels, Steven M.
   Burns, James A.
   Lopez-Guerra, Gerardo
   Anderson, R. Rox
   Hillman, Robert E.
TI Photoangiolytic laser treatment of early glottic cancer: A new
   management strategy
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT 88th Annual Meeting of the American-Broncho-Esophagological-Association
CY MAY 01-02, 2008
CL Orlando, FL
SP Amer Broncho Esophagol Assoc
DE glottis; laryngeal cancer; laser; microlaryngoscopy; phonomicrosurgery;
   phonosurgery; vocal cord; vocal fold; voice
ID PULSED DYE-LASER; VOCAL FOLD; LARYNGEAL CARCINOMAS; IN-SITU; SURGERY;
   VOICE; MICROSURGERY; DYSPLASIA; CO2-LASER; RADIATION
AB The 532 nm pulsed KTP (potassium titanyl phosphate) laser and the 585 nm pulsed dye laser (PDL) are photoangiolytic lasers that have been demonstrated to be effective for managing vocal fold dysplasia. The putative mechanism of action is selective photoangiolysis of the sublesional microcirculation. On the basis of this experience, early glottic cancers were treated by selectively targeting the intralesional and sublesional microvasculature. This approach was derived from Folk-man's concepts of neoplastic growth resulting from tumor angiogenesis. Staged microlaryngeal treatment was adopted, because it facilitated optimal functional results, and was considered safe, because early glottic cancer rarely metastasizes. Furthermore, intercurrent disease during conventional incremental radiotherapy is typical in treating early glottic cancer. A pilot group of 22 patients with early glottic cancer (13 T1, 9 T2) were treated with a fiber-based angiolytic laser. Eleven of the 22 had unilateral disease and were entirely treated by laser photoangiolysis as a sole modality. Eleven of the 22 had bilateral disease; 5 of the 11 were treated entirely (bilaterally) by laser photoangiolysis, and 6 of the 11 only underwent laser treatment of the less involved vocal fold, with conventional resection being done on the dominant side of the cancer. The initial 8 of the 22 were treated with the PDL, and the latter 14 of the 22 were treated with the pulsed KTP laser. No patient has cancer presently, and none have undergone posttreatment radiotherapy or open surgery. The mean follow-up is 27 months, 13 of the 22 patients have at least 2 years of follow-up, and the first patient was treated just over 5 years ago. Objective measures of vocal function revealed that photoangiolytic treatment of early glottic cancer resulted in significant postoperative improvements despite the fact that half of the patients had bilateral disease. Angiolytic lasers effectively involuted early glottic cancer, with microsurgically directed nonionizing radiation of the dense neoplastic blood supply resulting in complete tumor regression. This approach is conceptually attractive, because it is repeatable, it preserves all conventional cancer treatment options, and it results in excellent vocal function by improving phonatory mucosal wave vibration. Observations from this investigation suggest that this new and novel cancer treatment strategy is effective; however, larger patient cohorts, longer follow-up, and multi-institutional confirmation will be necessary to establish incontrovertible oncological efficacy.
C1 [Zeitels, Steven M.; Burns, James A.; Lopez-Guerra, Gerardo; Hillman, Robert E.] Massachusetts Gen Hosp, Ctr Laryngeal Surg & Voice Rehabil, Boston, MA 02114 USA.
   [Zeitels, Steven M.; Burns, James A.; Lopez-Guerra, Gerardo; Hillman, Robert E.] Harvard Univ, Sch Med, Dept Surg, Boston, MA 02115 USA.
   [Anderson, R. Rox] Harvard Univ, Sch Med, Dept Dermatol, Boston, MA 02115 USA.
   [Anderson, R. Rox] Massachusetts Gen Hosp, Wellman Labs Photomed, Boston, MA 02114 USA.
RP Zeitels, SM (reprint author), Massachusetts Gen Hosp, Ctr Laryngeal Surg & Voice Rehabil, 1 Bowdoin Sq, Boston, MA 02114 USA.
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NR 107
TC 9
Z9 9
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD JUL
PY 2008
VL 117
IS 7
SU 199
BP 3
EP 24
PN 2
PG 22
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 333EV
UT WOS:000258136500001
ER

PT J
AU McMurray, JS
   Connor, N
   Ford, CN
AF McMurray, J. Scott
   Connor, Nadine
   Ford, Charles N.
TI Cidofovir efficacy in recurrent respiratory papillomatosis: A
   randomized, double-blind, placebo-controlled study
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT 87th Annual Meeting of the American-Broncho-Esophagological-Association
CY APR 26-27, 2007
CL San Diego, CA
SP Amer Broncho Esophagol Assoc
DE cidofovir; recurrent respiratory papillomatosis
ID INTRALESIONAL CIDOFOVIR; LARYNGEAL PAPILLOMATOSIS; INJECTIONS; CHILDREN;
   THERAPY; SEVERITY; PROTOCOL; SYSTEM
AB Objectives: We performed a prospective, double-blind, placebo-controlled, longitudinal adjuvant therapy trial to determine the efficacy of cidofovir in the treatment of severe recurrent respiratory papillomatosis (RRP). Although results of case series suggest that cidofovir may decrease the frequency and rapidity of papilloma regrowth, no blinded placebo-controlled studies have demonstrated efficacy.
   Methods: Adults and children (n = 19) with aggressive RRP received either active drug (cidofovir) or placebo. When surgical intervention was needed, drug or placebo was injected into affected areas after surgical removal of disease. The following measures were made at baseline and at 2-month intervals for the course of 12 months: Derkay papilloma severity grading scale, Voice Handicap Index, Health-Related Quality of Life, and total number of procedures performed over 12 months.
   Results: At 2- and 12-month follow-ups, there was a significant (p <.05) improvement in the Derkay Severity Score within the cidofovir and placebo groups, but no difference between groups, and no difference between groups in the number of procedures performed. Significant improvement was found in Voice Handicap Index scores in the cidofovir group at the 12-month follow-up. No differences were seen in Health-Related Quality of Life.
   Conclusions: A randomized, blinded, placebo-controlled trial is necessary in the study of RRP, because the natural history of the disease can include remissions and reactivations. We found a significant improvement in the Derkay Severity Score 12 months after the baseline assessment in patients treated with cidofovir. This effect, however, was also seen in the placebo group. Accordingly, we were unable to provide proof of efficacy of cidofovir in the treatment of RRP.
C1 [McMurray, J. Scott; Connor, Nadine; Ford, Charles N.] Univ Wisconsin, Sch Med & Publ Hlth, Dept Surg, Div Otolaryngol Head & Neck Surg, Madison, WI 53792 USA.
RP McMurray, JS (reprint author), Univ Wisconsin, Sch Med & Publ Hlth, Dept Surg, Div Otolaryngol Head & Neck Surg, 600 Highland Ave,K4-710 CSC, Madison, WI 53792 USA.
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NR 20
TC 35
Z9 36
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD JUL
PY 2008
VL 117
IS 7
BP 477
EP 483
PN 1
PG 7
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 329VB
UT WOS:000257897600001
PM 18700421
ER

PT J
AU Lohscheller, J
   Doellinger, M
   McWhorter, AJ
   Kunduk, M
AF Lohscheller, Joerg
   Doellinger, Michael
   McWhorter, Andrew J.
   Kunduk, Melda
TI Preliminary study on the quantitative analysis of vocal loading effects
   on vocal fold dynamics using phonovibrograms
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE high-speed imaging; phonovibrogram; vocal fatigue; vocal fold dynamics
ID PHONATION THRESHOLD PRESSURE; HIGH-SPEED RECORDINGS; VOICE PRODUCTION;
   FATIGUE; VIBRATIONS; TEACHERS; VIDEOKYMOGRAPHY; MODEL; CLASSIFICATION;
   PARALYSIS
AB Objectives: The purpose of the present study was to determine whether high-speed digital imaging with phonovibrogram (PVG) analysis would identify changes in vocal fold vibratory characteristics following prolonged reading (vocal fatigue) in subjects with normal voice to evaluate the voice effects of vocal loading.
   Methods: Three healthy subjects' larynges were examined with an endoscopic high-speed imaging system at 4 different levels of vocal load. Vocal fold dynamics were segmented and processed by PVGs. The PVG images were quantitatively described by a parameter set enabling an individual characterization of vocal fold dynamics. To reveal differences between the subjects, we performed a linear discrimination analysis. Within each subject, the identification of vocal loading effects was performed by statistical analysis (1-way analysis of variance), and 2-tailed paired t-tests were used as a consistency check between left and right vocal fold sides.
   Results: For each subject, the PVG analysis enabled a precise quantification of the entire range of vocal fold dynamics. Independently of the high-speed videos (vocal loads), each subject could be identified by his or her PVG parameters on linear discrimination analysis. In all subjects, the effect of vocal loading was reflected by alterations of PVG parameters representing the posterior opening and closing dynamics. Evaluation within subjects revealed slight asymmetric vibratory behavior between the left and right vocal folds, confirming earlier assumptions.
   Conclusions: Within the investigated subjects, vocal loading does affect the vibratory characteristics of the vocal folds. Left-right vocal fold vibratory asymmetries do occur in healthy voices and can be identified by PVGs. High-speed digital imaging in combination with PVG analysis seems to be a promising tool for investigation of vocal fold fatigue and disorders resulting even from small dynamic changes.
C1 [Lohscheller, Joerg; Doellinger, Michael] Univ Hosp Erlangen, Sch Med, Dept Phoniatr & Pediat Audiol, D-91054 Erlangen, Germany.
   [McWhorter, Andrew J.; Kunduk, Melda] Louisiana State Univ, Hlth Sci Ctr, Dept Otolaryngol Head & Neck Surg, Baton Rouge, LA 70803 USA.
   [Kunduk, Melda] Louisiana State Univ, Dept Commun Sci & Disorders, Baton Rouge, LA 70803 USA.
RP Lohscheller, J (reprint author), Univ Hosp Erlangen, Sch Med, Dept Phoniatr & Pediat Audiol, Bohlenpl 21, D-91054 Erlangen, Germany.
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NR 41
TC 16
Z9 16
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD JUL
PY 2008
VL 117
IS 7
BP 484
EP 493
PN 1
PG 10
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 329VB
UT WOS:000257897600002
PM 18700422
ER

PT J
AU Plantinga, RF
   Pennings, RJE
   Huygen, PLM
   Bruno, R
   Eller, P
   Barrett, TG
   Vialettes, B
   Paquis-Fluklinger, V
   Lombardo, F
   Cremers, CWRJ
AF Plantinga, Rutger F.
   Pennings, Ronald J. E.
   Huygen, Patrick L. M.
   Bruno, Rocco
   Eller, Philipp
   Barrett, Timothy G.
   Vialettes, Bernard
   Paquis-Fluklinger, Veronique
   Lombardo, Fortunato
   Cremers, Cor W. R. J.
TI Hearing impairment in genotyped Wolfram syndrome patients
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE DIDMOAD; hereditary hearing impairment; sensorineural hearing
   impairment; WFS1; Wolfram syndrome
ID ENDOPLASMIC-RETICULUM STRESS; OPTIC ATROPHY; DIABETES-MELLITUS; DIDMOAD
   SYNDROME; WFS1 GENE; TRANSMEMBRANE PROTEIN; BETA-CELLS; MUTATIONS;
   PROGRESSION; DEAFNESS
AB Objectives: Wolfram syndrome is a progressive neurodegenerative syndrome characterized by the features "DIDMOAD" (diabetes insipidus, diabetes mellitus, optic atrophy, and deafness). We sought to study the audiometric data of genotyped Wolfram syndrome patients with sensorineural hearing impairment.
   Methods: Pure tone threshold data of 23 Wolfram syndrome patients were used for cross-sectional analysis in subgroups (age less than 16 years or between 19 and 25 years, gender, and origin).
   Results: All subgroups, with I exception, showed a fairly similar type of hearing impairment with, on average, thresholds of about 25 dB (range, 0 to 65 dB) at 0.25 to 1 kHz, gently sloping downward to about 60 dB (range, 25 to 95 dB) at 8 kHz. The subgroup of Dutch women, which was excluded from the calculations of the average hearing thresholds, showed a higher degree of hearing impairment. Only the latter subgroup showed progression; however, contrary to the previous longitudinal analysis, progression was not significant in the present cross-sectional analysis, presumably because of the high degree of cross-subject variability.
   Conclusions: This unique collection of audiometric data from genotyped Wolfram syndrome patients shows no substantial progression in sensorineural hearing impairment with advancing age, no relation to the types of WFS1 mutations identified, and, with exclusion of the subgroup of Dutch female patients, no significant sex-related differences.
C1 [Plantinga, Rutger F.; Pennings, Ronald J. E.; Huygen, Patrick L. M.; Cremers, Cor W. R. J.] Radboud Univ Nijmegen, Med Ctr, Dept Otorhinolaryngol, NL-6525 ED Nijmegen, Netherlands.
   [Bruno, Rocco] Univ Hosp, Dept Otorhinolaryngol, Messina, Italy.
   [Lombardo, Fortunato] Univ Hosp, Dept Pediat Sci, Messina, Italy.
   [Eller, Philipp] Med Univ Innsbruck, Dept Internal Med, Innsbruck, Austria.
   [Barrett, Timothy G.] Birmingham Childrens Hosp, Dept Endocrinol & Diabet, Birmingham, W Midlands, England.
   [Vialettes, Bernard] CHU Timone, Dept Nutr Metab Dis & Endocrinol, Marseille, France.
   [Paquis-Fluklinger, Veronique] Univ Nice Sophia Antipolis, CNRS, Nice, France.
   [Paquis-Fluklinger, Veronique] Univ Nice Sophia Antipolis, Archet Hosp 2, Dept Med Genet, Nice, France.
RP Plantinga, RF (reprint author), Radboud Univ Nijmegen, Med Ctr, Dept Otorhinolaryngol, NL-6525 ED Nijmegen, Netherlands.
RI Pennings, Ronald/J-6651-2012
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NR 26
TC 7
Z9 7
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD JUL
PY 2008
VL 117
IS 7
BP 494
EP 500
PN 1
PG 7
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 329VB
UT WOS:000257897600003
PM 18700423
ER

PT J
AU Sahin-Yilmaz, A
   Baroody, FM
   deTineo, M
   Cuttance, G
   Makinson, D
   Pinto, JM
   Naureckas, ET
   Naclerio, RM
AF Sahin-Yilmaz, Ash
   Baroody, Fuad M.
   deTineo, Marcy
   Cuttance, Georgina
   Makinson, Doug
   Pinto, Jayant M.
   Naureckas, Edward T.
   Naclerio, Robert M.
TI Effect of changing airway pressure on the ability of the human nose to
   warm and humidify air
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE continuous positive airway pressure; temperature; water content
ID OBSTRUCTIVE-SLEEP-APNEA; MOUTH LEAK; NASAL; THERAPY; RESISTANCE; TRIAL;
   CPAP
AB Objectives: Nasal continuous positive airway pressure (CPAP) treatment causes nasal symptoms that are believed to result from the drying effects of the air on the nasal mucosa, and these symptoms affect compliance with therapy. We hypothesized that the increased air pressure on the nasal mucosa caused by positive pressure from CPAP would decrease the ability of the nose to warm and humidify inspired air, explaining these symptoms.
   Methods: We performed a 4-way crossover trial using CPAP pressures of -5,0, +5, and +10 cm H2O in 10 subjects. The ability to warm and humidify inspired air was determined by measurement of the temperature of a fixed volume of cold, dry air entering and exiting the nostril and calculation of the amount of water supplied to the airstream by the nose.
   Results: The water content of air was unaffected at the pressures studied.
   Conclusions: The pressure of delivered CPAP does not affect the ability of the nose to warm and humidify inspired air.
C1 [Sahin-Yilmaz, Ash; Baroody, Fuad M.; deTineo, Marcy; Pinto, Jayant M.; Naclerio, Robert M.] Univ Chicago, Sect Otolaryngol Head & Neck Surg, Dept Surg, Chicago, IL 60637 USA.
   [Naureckas, Edward T.] Univ Chicago, Pulm & Crit Care Med Sect, Dept Med, Chicago, IL 60637 USA.
   [Cuttance, Georgina; Makinson, Doug] Fisher & Paykel Healthcare, Panmure, New Zealand.
RP Naclerio, RM (reprint author), Univ Chicago, Sect Otolaryngol Head & Neck Surg, Dept Surg, 5841 S Maryland Ave,MC 1035, Chicago, IL 60637 USA.
CR Anderson FE, 2003, SLEEP, V26, P721
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NR 20
TC 3
Z9 3
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD JUL
PY 2008
VL 117
IS 7
BP 501
EP 505
PN 1
PG 5
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 329VB
UT WOS:000257897600004
PM 18700424
ER

PT J
AU Bock, JA
   Trask, DK
AF Bock, Jonathan A.
   Trask, Douglas K.
TI Coblation-assisted lingual tonsillectomy for dysphagia secondary to
   tongue base hypertrophy
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE coblation; dysphagia; hypertrophy; lingual tonsil; tongue base;
   tonsillectomy
ID LYMPHOID-TISSUE; WALDEYERS RING; EXCISION; SURGERY; TONSIL; CELLS
AB Objectives: Lingual tonsillar hypertrophy is an underappreciated cause of dysphagia and is believed to impede swallowing function by inhibition of laryngeal elevation and epiglottic inversion due to mechanical interference by bulky tongue base tissue. We present a case of severe dysphagia secondary to idiopathic tongue base hypertrophy that was treated with coblation lingual tonsillectomy and tongue base reduction.
   Methods: We report a case and discuss the relevant literature regarding tongue base hypertrophy and surgical interventions to treat the enlarged base of the tongue.
   Results: Symptoms of dysphagia and globus sensation and signs of decreased epiglottic inversion and laryngeal penetration improved markedly after surgical reduction of hypertrophied lingual tonsillar tissue using coblation. Preoperative and postoperative clinical imaging and radiographs are presented to show the reduction of tongue base size, correlated with the patient's improved clinical function.
   Conclusions: Coblation-assisted lingual tonsillectomy and tongue base reduction can successfully treat dysphagia secondary to tongue base hypertrophy.
C1 [Bock, Jonathan A.; Trask, Douglas K.] Univ Iowa Hosp & Clin, Dept Otolaryngol Head & Neck Surg, Iowa City, IA 52242 USA.
RP Trask, DK (reprint author), Univ Iowa Hosp & Clin, Dept Otolaryngol Head & Neck Surg, 200 Hawkins Dr, Iowa City, IA 52242 USA.
CR Bortnick DP, 2001, PLAST RECONSTR SURG, V107, P614, DOI 10.1097/00006534-200102000-00053
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   Lee JT, 2000, AM J OTOLARYNG, V21, P271, DOI 10.1053/ajot.2000.8382
   Mamede RCM, 2004, OTOLARYNG HEAD NECK, V131, P378, DOI 10.1016/j.otohns.2004.02.040
   Maturo SC, 2006, ANN OTO RHINOL LARYN, V115, P624
   Maturo SC, 2006, OTOLARYNG HEAD NECK, V135, P487, DOI 10.1016/j.otohns.2006.04.015
   Ralph WM, 2001, ANN OTO RHINOL LARYN, V110, P790
   Robinson S, 2006, OTOLARYNG HEAD NECK, V134, P328, DOI 10.1016/j.otohns.2005.10.021
   Scharitzer M, 2002, EUR RADIOL, V12, P1139, DOI 10.1007/s00330-001-1202-4
   Temple RH, 2001, INT J PEDIATR OTORHI, V61, P195, DOI 10.1016/S0165-5876(01)00553-5
   Woodson BT, 2007, OPER TECHN OTOLARYNG, V18, P20, DOI 10.1016/j.otot.2007.03.004
NR 15
TC 7
Z9 7
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD JUL
PY 2008
VL 117
IS 7
BP 506
EP 509
PN 1
PG 4
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 329VB
UT WOS:000257897600005
PM 18700425
ER

PT J
AU Hoffman, HT
   Bock, JA
   Karnell, LH
   Ahlrichs-Hanson, J
AF Hoffman, Henry T.
   Bock, Jonathan A.
   Karnell, Lucy Hynds
   Ahlrichs-Hanson, Janice
TI Microendoscopy of Reinke's space
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE laryngoscopy; Reinke's space; sialoendoscopy; vocal fold
ID SURGERY; RECONSTRUCTION
AB Objectives: Contemporary surgical treatment of the superficial layer of the lamina propria or Reinke's space is most commonly performed through an incision in the overlying vocal fold epithelium. This approach may disrupt normal tissue, induce scarring, and allow extrusion of implanted materials. Previously reported external approaches to Reinke's space required either a laryngofissure or a "minithyrotomy" for access. These surgical approaches were performed without direct imaging of Reinke's space. Instruments placed below the vocal fold epithelium via this external approach were visualized through the translucent vocal fold epithelium. We designed this study to identify the feasibility of limited-access surgery of the lamina propria using microendoscopes placed into Reinke's space through an external approach.
   Methods: A cadaveric human larynx was dissected, and microendoscopes were directly advanced into Reinke's space through a subepithelial puncture of the cricothyroid membrane, as well as lateral fenestration through the thyroid cartilage.
   Results: Photodocumentation of the undersurface of vocal fold epithelium, the opposing surface of the vocal ligament, and the intervening Reinke's space was successfully accomplished.
   Conclusions: Advances in both microendoscopes and accompanying instrumentation permit access to the superficial layer of the lamina propria without disrupting the overlying epithelium. This approach to microendoscopy of Reinke's space may allow for more effective surgical treatment of cysts; chronic edema, vascular abnormalities, atrophy, scarring, and sulcus vocalis.
C1 [Hoffman, Henry T.; Bock, Jonathan A.; Karnell, Lucy Hynds; Ahlrichs-Hanson, Janice] Univ Iowa Hosp & Clin, Dept Otolaryngol Head & Neck Surg, Iowa City, IA 52242 USA.
RP Hoffman, HT (reprint author), Univ Iowa Hosp & Clin, Dept Otolaryngol Head & Neck Surg, 200 Hawkins Dr,21264 PFP, Iowa City, IA 52242 USA.
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   Faure F, 2007, LARYNGOSCOPE, V117, P1364, DOI 10.1097/MLG.0b013e318068657c
   Gray SD, 1999, ANN OTO RHINOL LARYN, V108, P1
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   Jovanovic MB, 2007, J VOICE, V21, P355, DOI 10.1016/j.jvoice.2006.01.004
   Koch M, 2005, OTOLARYNG HEAD NECK, V133, P863, DOI 10.1016/j.otohns.2005.08.005
   Sataloff RT, 2007, OTOLARYNG CLIN N AM, V40, P1151, DOI 10.1016/j.otc.2007.05.015
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NR 13
TC 2
Z9 2
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD JUL
PY 2008
VL 117
IS 7
BP 510
EP 514
PN 1
PG 5
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 329VB
UT WOS:000257897600006
PM 18700426
ER

PT J
AU Bhattacharyya, N
AF Bhattacharyya, Neil
TI Relationship between mucosal inflammation, computed tomography, and
   symptomatology in chronic rhinosinusitis without polyposis
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE chronic rhinosinusitis; histopathology; staging; symptom
ID CHRONIC SINUSITIS; EOSINOPHILIA; DIAGNOSIS; CRITERIA
AB Objectives: This study was an attempt to determine whether sinus mucosal inflammation is related to computed tomographic findings and patients' reported symptoms in chronic rhinosinusitis (CRS) without polyposis.
   Methods: I retrospectively reviewed the clinical symptom scores according to the Rhinosinusitis Symptom Inventory (RSI), the radiographic findings, and the histopathologic findings in the paranasal sinus mucosa for a consecutive series of adult patients who underwent endoscopic sinus surgery for CRS. Linear regression analysis was conducted for the relationship between tissue pathology inflammatory severity score graded on a 5-point Likert scale and the RSI symptom domains. A similar analysis was conducted for the relationship between the pathology inflammatory score and the total Lund score.
   Results: The study cohort consisted of 115 adult patients (mean age, 40.2 years). The mean Lund score for the cohort was 8.8 (95% confidence interval, 7.9 to 9.7), and the mean pathology severity score was 2.1 (median, 2.0). The mean total symptom score for the overall cohort was 41.3; the mean total symptom scores for pathology severity grades 0, 1, 2, 3, and 4 were 25.0, 43.8, 41.8, 42.4, and 32.8, respectively. No significant association could be identified between pathology severity and any of the 5 RSI symptom domains (nasal, facial, oropharyngeal, systemic, and total symptoms; all p >.436, linear regression). A statistically significant relationship between total Lund score and pathology severity was identified (p <.001).
   Conclusions: Poor correlation exists between the histopathologic severity of sinonasal inflammation and self-reported symptom scores in CRS. Histopathologic inflammatory grade alone fails to stratify CRS cases according to disease symptom severity. Histopathologic inflammation and computed tomographic findings con-elate strongly.
C1 [Bhattacharyya, Neil] Brigham & Womens Hosp, Div Otolaryngol, Boston, MA 02115 USA.
   [Bhattacharyya, Neil] Harvard Univ, Sch Med, Dept Otol & Laryngol, Boston, MA 02115 USA.
RP Bhattacharyya, N (reprint author), Brigham & Womens Hosp, Div Otolaryngol, 75 Francis St, Boston, MA 02115 USA.
CR Bhattacharyya N, 2005, AM J RHINOL, V19, P175
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   Bhattacharyya N, 2001, ARCH OTOLARYNGOL, V127, P1102
   Bhattacharyya N, 2003, AM J RHINOL, V17, P27
   Bhattacharyya N, 2003, LARYNGOSCOPE, V113, P125, DOI 10.1097/00005537-200301000-00023
   Bhattacharyya T, 1997, ARCH OTOLARYNGOL, V123, P1189
   Biedlingmaier JF, 1998, OTOLARYNG HEAD NECK, V118, P165, DOI 10.1016/S0194-5998(98)80005-3
   Cousin JN, 2000, J OTOLARYNGOL, V29, P170
   Hopkins C, 2007, OTOLARYNG HEAD NECK, V137, P555, DOI 10.1016/j.otohns.2007.02.004
   Hwang PH, 2003, OTOLARYNG HEAD NECK, V128, P489, DOI 10.1016/mhn.2003.95
   Krouse JH, 2000, OTOLARYNG HEAD NECK, V123, P389, DOI 10.1067/mhn.2000.109476
   Meltzer EO, 2004, OTOLARYNG HEAD NECK, V131, pS1, DOI 10.1016/j.otohns.2004.09.067
   Polzehl D, 2006, ALLERGY, V61, P1275, DOI 10.1111/j.1398-9995.2006.01132.x
   Shields G, 2003, LARYNGOSCOPE, V113, P943, DOI 10.1097/00005537-200306000-00006
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NR 16
TC 9
Z9 9
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD JUL
PY 2008
VL 117
IS 7
BP 517
EP 522
PN 1
PG 6
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 329VB
UT WOS:000257897600008
PM 18700427
ER

PT J
AU Birkent, H
   Karacalioglu, O
   Merati, AL
   Akcam, T
   Gerek, M
AF Birkent, Hakan
   Karacalioglu, Ozgur
   Merati, Albert L.
   Akcam, Timur
   Gerek, Mustafa
TI Prospective study of the impact of thyroid hormone replacement on
   objective voice parameters
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT 88th Annual Meeting of the American-Broncho-Esophagological-Association
CY MAY 01-02, 2008
CL Orlando, FL
SP Amer Broncho Esophagol Assoc
DE fundamental frequency; hoarseness; hypothyroidism; thyroid hormone;
   voice
ID FEMALE VOICE; LARYNX; HYPOTHYROIDISM; QUALITY
AB Objectives: Hypothyroidism has long been considered to have an impact on phonation. In this study, objective evaluation of vocal function in women with hypothyroidism was performed in order to characterize potential dysphonia; their subsequent response to thyroid hormone replacement was prospectively studied. It was hypothesized that thyroid hormone replacement therapy in this cohort would have an objectively measurable impact on vocal function.
   Methods: Prospective evaluation of objective voice parameters and concurrent determination of serum thyroid status was executed both before and after thyroid hormone replacement in a cohort of patients who had had total thyroidectomy. Objective voice parameters before and after treatment were compared.
   Results: Twenty-four female subjects were recruited over an 18-month period. After surgery, all subjects were hypothyroid (mean thyroid-stimulating hormone level, 81.38 mIU/L; range, 25.26 to 100.00 mIU/L) before replacement. After hormone therapy, their mean thyroid-stimulating hormone level dropped to 1.20 mIU/L (range, 0.28 to 3.83 mIU/L). The mean fundamental frequency significantly increased from a pretreatment average of 223.48 +/- 36.10 Hz to 237.64 +/- 38.81 Hz. Other measured voice parameters (jitter, shimmer, amplitude perturbation quotient, pitch perturbation quotient, noise-to-harmonics ratio, and maximum phonation time) were not affected.
   Conclusions: Thyroid hormone replacement therapy following total thyroidectomy has a measurable impact on mean fundamental frequency in female patients. The mechanism of this effect is not known.
C1 [Merati, Albert L.] Univ Washington, Dept Otolaryngol Head & Neck Surg, Div Laryngol, Seattle, WA 98195 USA.
   [Birkent, Hakan; Akcam, Timur; Gerek, Mustafa] Gulhane Mil Med Acad, Dept Otolaryngol Head & Neck Surg, Ankara, Turkey.
   [Karacalioglu, Ozgur] Gulhane Mil Med Acad, Dept Nucl Med, Ankara, Turkey.
RP Birkent, H (reprint author), Univ Washington, Dept Otolaryngol Head & Neck Surg, Div Laryngol, 1959 NE Pacific St,Box 356515, Seattle, WA 98195 USA.
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   MICHAELS L, 1984, PATHOLOGY LARYNX, P353
   RITTER FN, 1964, ANN OTO RHINOL LARYN, V73, P404
   RITTER FN, 1967, LARYNGOSCOPE, V77, P1427, DOI 10.1288/00005537-196708000-00016
   SATALOFF RT, 1991, PROFESSIONAL VOICE S, P201
   SCHERER RC, 1995, J SPEECH HEAR RES, V38, P1260
   TITZE IR, 1987, J SPEECH HEAR RES, V30, P252
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NR 25
TC 5
Z9 5
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD JUL
PY 2008
VL 117
IS 7
BP 523
EP 527
PN 1
PG 5
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 329VB
UT WOS:000257897600009
PM 18700428
ER

PT J
AU Shihada, R
   Fradis, M
   Vardizer, Y
   Braun, J
   Luntz, M
AF Shihada, Rabia
   Fradis, Milo
   Vardizer, Yoav
   Braun, Jacob
   Luntz, Michal
TI Unilateral blindness following septoplasty
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE blindness; orbital apex syndrome; septoplasty
ID COMPLICATION; RHINOPLASTY
AB Visual loss following routine nasal surgery is an extremely rare and devastating complication. We report a case of unilateral blindness due to orbital apex syndrome following septoplasty. We also review the literature and discuss probable causes. To the best of our knowledge, this is only the second published report of this complication.
C1 [Shihada, Rabia; Fradis, Milo; Luntz, Michal] Technion Israel Inst Technol, Bnai Zion Med Ctr, Dept Otolaryngol Head & Neck Surg, IL-31048 Haifa, Israel.
   [Vardizer, Yoav] Technion Israel Inst Technol, Bnai Zion Med Ctr, Dept Ophthalmol, IL-31048 Haifa, Israel.
   [Braun, Jacob] Technion Israel Inst Technol, Bnai Zion Med Ctr, Dept Radiol, IL-31048 Haifa, Israel.
RP Luntz, M (reprint author), Technion Israel Inst Technol, Bnai Zion Med Ctr, Dept Otolaryngol Head & Neck Surg, POB 4940, IL-31048 Haifa, Israel.
CR CHENEY ML, 1987, ARCH OTOLARYNGOL, V113, P768
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NR 11
TC 3
Z9 3
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD JUL
PY 2008
VL 117
IS 7
BP 528
EP 530
PN 1
PG 3
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 329VB
UT WOS:000257897600010
PM 18700429
ER

PT J
AU Visosky, AMB
   Parke, RB
   Donovan, DT
AF Visosky, Ann Marie B.
   Parke, Robert B.
   Donovan, Donald T.
TI Endoscopic management of Zenker's diverticulum: Factors predictive of
   success or failure
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT 87th Annual Meeting of the American-Broncho-Esophagological-Association
CY APR 26-27, 2007
CL San Diego, CA
SP Amer Broncho Esophagol Assoc
DE endoscopic diverticulotomy; esophageal diverticulum; Zenker's
   diverticulum
ID STAPLE-ASSISTED ESOPHAGODIVERTICULOSTOMY; PHARYNGEAL POUCH;
   HYPOPHARYNGEAL DIVERTICULA; ESOPHAGEAL-PERFORATION; CHOICE
AB Objectives: We review our experience with endoscopic management of Zenker's diverticulum. We sought to analyze and determine risk factors for success or failure of endoscopic diverticulum treatment.
   Methods: We performed a retrospective review of 72 consecutive patients who underwent attempted endoscopic management of a Zenker's diverticulum between January 2000 and April 2006. The procedures were performed by either of 2 otolaryngologists. There were 50 men and 22 women ranging in age from 44 to 93 years. A total of 85 procedures were performed. The medical records were reviewed for preoperative diverticulum size (small, 1 to 2 cm; moderate, 2.1 to 3.0 cm; and large, more than 3.0 cm), intraoperative diverticulum characteristics, patient anatomic limitations that prevented adequate endoscopic visualization, surgical complications, and management of recurrences.
   Results: Of our 72 patients, 61 (85%) were able to undergo endoscopic cricopharyngeal myotomy with diverticulum elimination. Of the 61 endoscopic procedures, 47 (77%) resulted in complete symptom resolution. The most common risk factors for recurrence were diverticulum size (more than 3 cm) and amount of redundant mucosa. Of the 14 patients with a recurrence, 10 (71%) underwent a repeat procedure. Six of the 14 (43%) had a successful excision via a cervical approach, and 4 of the 14 (29%) underwent a repeat endoscopic myotomy. There was I major complication (esophageal tear), and there were 3 minor complications (mucosal abrasions).
   Conclusions: Most patients with a Zenker's diverticulum are good candidates for endoscopic management. In our series, 84% of those who underwent endoscopic treatment ultimately achieved relief of symptoms. The patient morbidity is minimal. A large diverticulum with redundant mucosa is a risk factor for recurrence after endoscopic treatment.
C1 [Visosky, Ann Marie B.; Parke, Robert B.; Donovan, Donald T.] Baylor Coll Med, Bobby R Alford Dept Otolaryngol Head & Neck Surg, Houston, TX 77030 USA.
RP Donovan, DT (reprint author), Baylor Coll Med, Bobby R Alford Dept Otolaryngol Head & Neck Surg, 1 Baylor Plaza,NA 102, Houston, TX 77030 USA.
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   Tsikoudas A, 2006, ANN OTO RHINOL LARYN, V115, P721
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NR 21
TC 22
Z9 23
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD JUL
PY 2008
VL 117
IS 7
BP 531
EP 537
PN 1
PG 7
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 329VB
UT WOS:000257897600011
PM 18700430
ER

PT J
AU Vokes, DE
   Jackson, R
   Guo, SG
   Perez, JA
   Su, JP
   Ridgway, JM
   Armstrong, WB
   Chen, ZP
   Wong, BJF
AF Vokes, David E.
   Jackson, Ryan
   Guo, Shuguang
   Perez, Jorge A.
   Su, Jianping
   Ridgway, James M.
   Armstrong, William B.
   Chen, Zhongping
   Wong, Brian J. F.
TI Optical coherence tomography-enhanced microlaryngoscopy: Preliminary
   report of a noncontact optical coherence tomography system integrated
   with a surgical microscope
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT 127th Annual Meeting of the American-Laryngological-Association
CY MAY 19-20, 2006
CL Chicago, IL
SP Amer Laryngol Assoc
DE laryngeal imaging; laryngoscopy; larynx; optical coherence tomography;
   vocal cord; vocal fold
ID IN-VIVO; VOCAL FOLD; BLOOD-FLOW; HUMAN SKIN; MUCOSA; AIRWAY; VELOCITY;
   CANCER
AB Objectives: Optical coherence tomography (OCT) is a new imaging modality that uses near-infrared light to produce cross-sectional images of tissue with a resolution approaching that of light microscopy. We have previously reported use of OCT imaging of the vocal folds (VFs) during direct laryngoscopy with a probe held in contact or near-contact with the VFs. This aim of this study was to develop and evaluate a novel OCT system integrated with a surgical microscope to allow hands-free OCT imaging of the VFs, which could be performed simultaneously with microscopic visualization.
   Methods: We performed a prospective evaluation of a new method of acquiring OCT images of the VFs.
   Results: An OCT system was successfully integrated with a surgical microscope to permit noncontact OCT imaging of the VFs of 10 patients. With this novel device we were able to identify VF epithelium and lamina propria; however, the resolution was reduced compared to that achieved with the standard contact or near-contact OCT.
   Conclusions: Optical coherence tomography is able to produce high-resolution images of vocal fold mucosa to a maximum depth of 1.6 mm. It may be used in the diagnosis of VF lesions, particularly early squamous cell carcinoma, in which OCT can show disruption of the basement membrane. Mounting the OCT device directly onto the operating microscope allows hands-free noncontact OCT imaging and simultaneous conventional microscopic visualization of the VFs. However, the lateral resolution of the OCT microscope system is 50 pm, in contrast to the conventional handheld probe system (10 mu m). Although such images at this resolution are still useful clinically, improved resolution would enhance the system's performance, potentially enabling real-time OCT-guided microsurgery of the larynx.
C1 [Jackson, Ryan; Guo, Shuguang; Perez, Jorge A.; Su, Jianping; Chen, Zhongping; Wong, Brian J. F.] Univ Calif Irvine, Beckman Laser Inst, Dept Biomed Engn, Irvine, CA 92612 USA.
   [Vokes, David E.; Ridgway, James M.; Armstrong, William B.; Wong, Brian J. F.] Univ Calif Irvine, Irvine Med Ctr, Dept Otolaryngol Head & Neck Surg, Orange, CA 92668 USA.
RP Wong, BJF (reprint author), Univ Calif Irvine, Beckman Laser Inst, Dept Biomed Engn, 1002 Hlth Sci Rd E, Irvine, CA 92612 USA.
EM z2chen@uci.edu; bjwong@uci.edu
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NR 23
TC 13
Z9 15
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD JUL
PY 2008
VL 117
IS 7
BP 538
EP 547
PN 1
PG 10
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 329VB
UT WOS:000257897600012
PM 18700431
ER

PT J
AU Jiang, JJ
   Regner, MF
   Tao, C
   Pauls, S
AF Jiang, Jack J.
   Regner, Michael F.
   Tao, Chao
   Pauls, Steven
TI Phonation threshold flow in elongated excised larynges
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE excised larynx; phonation; phonation threshold flow; phonation threshold
   pressure; vocal fold elongation
ID AIR-FLOW; SUBGLOTTAL PRESSURE; CANINE LARYNGES; INTERRUPTION;
   DEHYDRATION; EFFICIENCY
AB Objectives: This study proposes the use of a new parameter of vocal aerodynamics, phonation threshold flow (PTF). The sensitivities of the PTF and the phonation threshold pressure (PTP) were quantitatively compared to the percent of vocal fold elongation from physiologic length.
   Methods: Ten excised canine larynges were mounted on a bench apparatus capable of controlling vocal fold elongation. Subglottal airflow was gradually increased until the onset of phonation. Elongation of the vocal folds was varied from +0% (physiologic length) to +15%, and the PTF and PTP were measured.
   Results: The mean PTFs at physiologic vocal fold length ranged from 101 to 217 mL/s. No statistically significant relationship was found to exist between the size of the larynx and the measured PTF values (p =.404). The average percent change of PTF compared to the magnitude of elongation was found to be statistically significant (p <.001). The data indicated that the PTF was proportional to the percent of vocal fold elongation.
   Conclusions: The PTF was positively correlated with vocal fold elongation and the PTP for small magnitudes of elongation. The results suggest that the PTF may be indicative of the biomechanical properties of the vocal folds, thus providing a possibly valuable tool in the clinical evaluation of laryngeal function.
C1 [Jiang, Jack J.; Regner, Michael F.; Tao, Chao; Pauls, Steven] Univ Wisconsin, Madison Sch Med & Publ Hlth, Dept Surg, Div Otolaryngol Head & Neck Surg, Madison, WI 53706 USA.
RP Jiang, JJ (reprint author), Univ Wisconsin, Sch Med, Med Sci Ctr, Room 5745,1300 Univ Ave, Madison, WI 53706 USA.
CR BARD MC, 1992, ANN OTO RHINOL LARYN, V101, P578
   Fisher KV, 1997, J SPEECH LANG HEAR R, V40, P1122
   Holmberg EB, 2003, J VOICE, V17, P269, DOI 10.1067/S0892-1997(03)00076-6
   Hottinger DG, 2007, LARYNGOSCOPE, V117, P1695, DOI 10.1097/MLG.0b013e3180959e38
   Jiang J, 1999, LARYNGOSCOPE, V109, P425, DOI 10.1097/00005537-199903000-00016
   Jiang J, 2000, ANN OTO RHINOL LARYN, V109, P568
   Jiang J, 2006, LARYNGOSCOPE, V116, P89, DOI 10.1097/01.mlg.0000184315.00648.2f
   Jiang JJ, 2007, J ACOUST SOC AM, V121, P2873, DOI 10.1121/1.2710961
   Jiang JJ, 2000, LARYNGOSCOPE, V110, P1567, DOI 10.1097/00005537-200009000-00032
   TITZE IR, 1989, J ACOUST SOC AM, V85, P901, DOI 10.1121/1.397562
   TITZE IR, 1992, J ACOUST SOC AM, V91, P2926, DOI 10.1121/1.402928
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   Verdolini K, 2002, J SPEECH LANG HEAR R, V45, P268, DOI 10.1044/1092-4388(2002/021)
NR 13
TC 7
Z9 9
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD JUL
PY 2008
VL 117
IS 7
BP 548
EP 553
PN 1
PG 6
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 329VB
UT WOS:000257897600013
PM 18700432
ER

PT J
AU Beijen, JW
   Mylanus, EAM
   Leeuw, AR
   Snik, AFM
AF Beijen, Jan-Willem
   Mylanus, Emmanuel A. M.
   Leeuw, A. Rens
   Snik, Ad F. M.
TI Should a hearing aid in the contralateral ear be recommended for
   children with a unilateral cochlear implant?
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE bimodal fitting; child; cochlear implant; hearing aid
ID BIMODAL STIMULATION; BENEFITS; SPEECH
AB Objectives: To predict bimodal benefit before cochlear implantation, we compared the performances of participants with bimodal fitting and with a cochlear implant alone on speech perception tests.
   Methods: Twenty-two children with a cochlear implant in one ear and a hearing aid in the other (bimodal fitting) were included. Several aided and unaided average hearing thresholds and the aided word recognition score of the hearing aid ear were related to the bimodal benefit on a phoneme recognition test in quiet and in noise. Results with bimodal fitting were compared to results with the cochlear implant alone on a phoneme recognition test in quiet and in noise.
   Results: No relationship was found between any of the hearing thresholds or the aided phoneme recognition score of the hearing aid ear and the bimodal benefit on the phoneme recognition tests. At the group level, the bimodal scores on the phoneme recognition tests in quiet and in noise were significantly better than the scores with the cochlear implant alone.
   Conclusions: Preoperatively available audiometric parameters are not reliable predictors of bimodal benefit in candidates for cochlear implantation. Children with unilateral implants benefit from bimodal fitting on speech tests. This improvement in performance warrants the recommendation of bimodal fitting even when bimodal benefit cannot be predicted.
C1 [Beijen, Jan-Willem; Mylanus, Emmanuel A. M.; Snik, Ad F. M.] Radboud Univ Nijmegen, Med Ctr, Dept Otorhinolaryngol, NL-6500 HB Nijmegen, Netherlands.
   [Leeuw, A. Rens] Diagnost Ctr Viataal, St Michielsgestel, Netherlands.
RP Beijen, JW (reprint author), Radboud Univ Nijmegen, Med Ctr, Dept Otorhinolaryngol, Philips van Leydenlaan 15, NL-6500 HB Nijmegen, Netherlands.
RI Mylanus, Emmanuel/D-2255-2010; Snik, Ad/H-8092-2014
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NR 17
TC 9
Z9 12
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD JUN
PY 2008
VL 117
IS 6
BP 397
EP 403
PG 7
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 317NG
UT WOS:000257026300001
PM 18646435
ER

PT J
AU Popolo, PS
   Titze, IR
AF Popolo, Peter S.
   Titze, Ingo R.
TI Qualification of a quantitative laryngeal imaging system using
   videostroboscopy and videokymography
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE endoscope; glottal width; laser; videokymography; videostroboscopy;
   vocal fold
AB Objectives: We sought to determine whether full-cycle glottal width measurements could be obtained with a quantitative laryngeal imaging system using videostroboscopy, and whether glottal width and vocal fold length measurements were repeatable and reliable.
   Methods: Synthetic vocal folds were phonated on a laboratory bench, and dynamic images were obtained in repeated trials by use of videostroboscopy and videokymography (VKG) with an imaging system equipped with a 2-point laser projection device for measuring absolute dimensions. Video images were also obtained with an industrial videoscope system with a built-in laser measurement capability. Maximum glottal width and vocal fold length were compared among these 3 methods.
   Results: The average variation in maximum glottal width measurements between stroboscopic data and VKG data was 3.10%. The average variations in width measurements between the clinical system and the industrial system were 1.93% (stroboscopy) and 3.49% (VKG). The variations in vocal fold length were similarly small. The standard deviations across trials were 0.29 mm for width and 0.48 mm for length (stroboscopy), 0.18 mm for width (VKG), and 0.25 mm for width and 0.84 mm for length (industrial).
   Conclusions: For stable, periodic vibration, the full extent of the glottal width can be reliably measured with the quantitative videostroboscopy system.
C1 [Popolo, Peter S.; Titze, Ingo R.] Denver Ctr Performing Arts, Natl Ctr Voice & Speech, Denver, CO 80204 USA.
RP Popolo, PS (reprint author), Denver Ctr Performing Arts, Natl Ctr Voice & Speech, 1101 13th St,4th Floor, Denver, CO 80204 USA.
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NR 10
TC 15
Z9 15
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD JUN
PY 2008
VL 117
IS 6
BP 404
EP 412
PG 9
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 317NG
UT WOS:000257026300002
PM 18646436
ER

PT J
AU Patel, R
   Dailey, S
   Bless, D
AF Patel, Rita
   Dailey, Seth
   Bless, Diane
TI Comparison of high-speed digital imaging with stroboscopy for laryngeal
   imaging of glottal disorders
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE glottal disorder; high-speed digital imaging; hoarseness; stroboscopy;
   voice disorder
AB Objectives: High-speed digital imaging (HSDI), unlike stroboscopy, is a frequency-independent visualization technique that provides detailed biomechanical assessment of vocal physiology due to increased temporal resolution. The purpose of this study was to investigate the clinical value of HSDI compared to that of stroboscopy across 3 disorder groups classified as epithelial, subepithelial, and neurologic disorders.
   Methods: Judgments of vibratory features of vocal fold edge, glottal closure, phase closure, vertical level, vibratory amplitude, mucosal wave, phase symmetry, tissue pliability, and glottal cycle periodicity from 252 participants were performed by 3 experienced raters.
   Results: The results revealed that 63% of the data set was noninterpretable for assessment of vibratory function on stroboscopic analysis because of the severity of the voice disorder (100% of participants with severe voice disorders and 64% of participants with moderate voice disorders), whereas HSDI resulted in analysis of 100% of the data. The neuromuscular group (74%) was the most difficult to analyze with stroboscopy, followed by the epithelial (58%) and subepithelial groups (53%), secondary to the severity of hoarseness.
   Conclusions: Because it is desirable in clinical examination to observe vocal fold vibrations, which cannot be done in cases of severe dysphonia, HSDI may aid in clinical decision-making when patients exhibit values exceeding 0.87% jitter, 4.4% shimmer, and a signal-to-noise ratio of less than 15.4 dB on acoustic analysis. These measures could serve as minimal indications for use of HSDI. The data suggest that HSDI can be viewed as augmentative to stroboscopy, particularly in cases of moderate to severe aperiodicity, in which HSDI may aid clinical decision-making.
C1 [Patel, Rita] Univ Wisconsin, Sch Med, Dept Surg, Div Otolaryngol Head & Neck Surg, Madison, WI 53792 USA.
RP Patel, R (reprint author), Univ Wisconsin, Sch Med, Dept Surg, Div Otolaryngol Head & Neck Surg, G3-236 Clin Sci Ctr,600 Highland Ave, Madison, WI 53792 USA.
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NR 22
TC 54
Z9 56
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD JUN
PY 2008
VL 117
IS 6
BP 413
EP 424
PG 12
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 317NG
UT WOS:000257026300003
PM 18646437
ER

PT J
AU Kindermann, CA
   Roithmann, R
   Neto, JFL
AF Kindermann, Christine Aparecida
   Roithmann, Renato
   Lubianca Neto, Jose Faibes
TI Obstruction of the eustachian tube orifice and pressure changes in the
   middle ear: Are they correlated?
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE adenoid; adenoid hyperplasia; eustachian tube; nasal obstruction; otitis
   media with effusion; recurrent otitis media
ID ACUTE OTITIS-MEDIA; TYMPANOSTOMY TUBES; FIBEROPTIC EXAMINATION;
   RISK-FACTORS; CHILDREN; EFFUSION; ADENOIDECTOMY; TYMPANOMETRY;
   ENDOSCOPY; DIAGNOSIS
AB Objectives: We performed a cross-sectional study to investigate whether the obstruction of the eustachian tube orifice due to adenoid hyperplasia changes the pressures in the middle ear.
   Method: Fifty consecutive children 2 to 12 years of age with nasal obstruction were examined from May to October 2005. Adenoid size and status of the eustachian tube orifice were assessed with nasal flexible fiberoptic endoscopy. Tympanometry was used to evaluate the middle ear.
   Results: In children with occlusion of the eustachian tube orifice by adenoid tissue, 87% had abnormal pressure in the middle ear according to tympanograms. When orifices were not occluded, 86% of the tympanograms were normal (p < .001).
   Conclusions: Obstruction of the eustachian tube orifice by adenoid tissue was associated with tympanograms suggestive of abnormal pressure in the middle ear. Future studies with a larger sample size are necessary to clarify this association.
C1 [Kindermann, Christine Aparecida; Lubianca Neto, Jose Faibes] Univ Fed Rio Grande do Sul, Sch Med, Postgrad Program Med Sci, BR-90046900 Porto Alegre, RS, Brazil.
   [Roithmann, Renato] Univ Luterana Brasil, Dept Otolaryngol, Canoas, Rio Grande Sul, Brazil.
   [Lubianca Neto, Jose Faibes] Fed Fdn Med Sci, Dept Ophthalmol & Otolaryngol, Porto Alegre, RS, Brazil.
   [Lubianca Neto, Jose Faibes] Santo Antonio Childrens Hosp, Div Pediat Otolaryngol, Porto Alegre, RS, Brazil.
RP Kindermann, CA (reprint author), Rua Prof Annes Dias 112-52, BR-90020090 Porto Alegre, RS, Brazil.
CR Alper CM, 2003, ANN OTO RHINOL LARYN, V112, P877
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NR 28
TC 2
Z9 3
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD JUN
PY 2008
VL 117
IS 6
BP 425
EP 429
PG 5
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 317NG
UT WOS:000257026300004
PM 18646438
ER

PT J
AU Kimura, M
   Nito, T
   Imagawa, H
   Tayama, N
   Chan, RW
AF Kimura, Miwako
   Nito, Takaharu
   Imagawa, Hiroshi
   Tayama, Niro
   Chan, Roger W.
TI Collagen injection as a supplement to arytenoid adduction for vocal fold
   paralysis
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE augmentation; collagen; laryngeal paralysis; vocal fold medialization
ID GLOTTIC INSUFFICIENCY; INJECTABLE COLLAGEN; HOMOLOGOUS COLLAGEN;
   AUGMENTATION; IMMOBILITY
AB Objectives: Dysphonia associated with vocal fold paralysis can persist even after successful medialization procedures, including arytenoid adduction. It is hypothesized that laryngeal collagen injection could improve phonation following arytenoid adduction in selected patients. Our objective was to evaluate how collagen injection could result in measurable improvements in vocal function and voice quality.
   Methods: Forty patients with unilateral vocal fold paralysis who had undergone arytenoid adduction underwent transoral injection of non-cross-linked bovine dermal collagen by means of indirect laryngoscopy and a curved injection device. A control group of 40 patients underwent arytenoid adduction but not collagen injection. The patients' voice quality was assessed perceptually with the GRBAS scale, and vocal function was assessed by acoustic and aerodynamic measures (maximum phonation time and transglottal DC flow). The relative glottal area was also assessed by videostroboscopy.
   Results: Significant improvements in vocal function and voice quality were observed with collagen injection for those patients who did not achieve satisfactory glottal competence with arytenoid adduction alone. Glottal area measurements revealed that glottic insufficiency was significantly reduced after arytenoid adduction as well as after collagen injection.
   Conclusions: The findings suggest that collagen injection could be an effective supplementary treatment for improving voice following arytenoid adduction. It has the advantage of being a minimally invasive outpatient office procedure. The long-term efficacy of the procedure should be explored.
C1 [Chan, Roger W.] Univ Texas SW Med Ctr Dallas, Dept Otolaryngol Head & Neck Surg, Dallas, TX 75390 USA.
   [Kimura, Miwako; Nito, Takaharu; Imagawa, Hiroshi] Univ Tokyo, Fac Med, Tokyo 113, Japan.
   [Kimura, Miwako; Nito, Takaharu; Imagawa, Hiroshi] Univ Tokyo, Grad Sch Med, Dept Otorhinolaryngol Head & Neck Surg, Tokyo 1138654, Japan.
   [Tayama, Niro] Int Med Ctr Japan, Div Otolaryngol & Tracheoesophagol, Tokyo, Japan.
RP Chan, RW (reprint author), Univ Texas SW Med Ctr Dallas, Dept Otolaryngol Head & Neck Surg, 5323 Harry Hines Blvd, Dallas, TX 75390 USA.
CR Chan RW, 1997, J ACOUST SOC AM, V101, P3722, DOI 10.1121/1.418331
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NR 23
TC 6
Z9 7
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD JUN
PY 2008
VL 117
IS 6
BP 430
EP 436
PG 7
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 317NG
UT WOS:000257026300005
PM 18646439
ER

PT J
AU Paniello, RC
   Sulica, L
   Khosla, SM
   Smith, ME
AF Paniello, Randal C.
   Sulica, Lucian
   Khosla, Siddarth M.
   Smith, Marshall E.
TI Clinical experience with Gray's minithyrotomy procedure
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE fat implant; Gray's minithyrotomy; vocal fold
ID AUTOLOGOUS FAT IMPLANTATION; VOCAL FOLD SCAR; CANINE
AB Objectives: Endoscopic approaches for submucosal vocal fold surgery may limit the surgeon's ability to release scars or to precisely implant filler material such as fat. In 1999, Gray et al described the "minithyrotomy" approach to this region. Technical aspects of this important new technique, clinical indications, and early results are reviewed.
   Methods: We performed a retrospective review and compiled the data of the office records, clinical notes, and videostroboscopic examinations of all of the four authors' patients who underwent this procedure.
   Results: Twenty-one patients underwent 22 minithyrotomy procedures for vocal fold scarring (6), lateralizing scar following polytetrafluoroethylene removal or trauma (5), scar with radiation fibrosis (2), sulcus vocalis (2), or presbylarynx or bowing (6) - bilaterally in 14 operations and unilaterally in 8. There were 13 male patients and 8 female patients, with a mean age of 58.3 years (range, 22 to 87 years). The mean follow-up was 9.1 months (range, 1 to 46 months). After submucosal vocal fold exploration, autologous fat was implanted in 20 of the 21 patients. Postoperative videostroboscopy demonstrated improved mucosal pliability in 19 cases and improved glottal closure in 20 cases. Most patients noted voice improvement. Complications were minimal.
   Conclusions: Gray's minithyrotomy is a highly effective approach for treating vocal fold scar processes, bowing, sulcus vocalis, and, potentially, other conditions.
C1 [Paniello, Randal C.] Washington Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, St Louis, MO 63110 USA.
   [Sulica, Lucian] Beth Israel Deaconess Med Ctr, Dept Otolaryngol Head & Neck Surg, New York, NY 10003 USA.
   [Khosla, Siddarth M.] Univ Cincinnati, Dept Otolaryngol Head & Neck Surg, Cincinnati, OH USA.
   [Smith, Marshall E.] Univ Utah, Dept Otolaryngol Head & Neck Surg, Salt Lake City, UT USA.
RP Paniello, RC (reprint author), Washington Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, 660 S Euclid Ave,Campus Box 8115, St Louis, MO 63110 USA.
CR Chan RW, 1998, LARYNGOSCOPE, V108, P725, DOI 10.1097/00005537-199805000-00019
   Chan RW, 1999, LARYNGOSCOPE, V109, P1142, DOI 10.1097/00005537-199907000-00026
   Duprat AD, 2004, ANN OTO RHINOL LARYN, V113, P636
   Gray SD, 1999, ANN OTO RHINOL LARYN, V108, P1
   JIANG JJ, 1994, ANN OTO RHINOL LARYN, V103, P145
   Neuenschwander MC, 2001, J VOICE, V15, P295, DOI 10.1016/S0892-1997(01)00031-5
   Saccogna PW, 1997, OTOLARYNG HEAD NECK, V117, P465, DOI 10.1016/S0194-5998(97)70015-9
   Sataloff RT, 1997, J VOICE, V11, P238
   WEXLER DB, 1989, ANN OTO RHINOL LARYN, V98, P668
   Woo P, 1999, ANN OTO RHINOL LARYN, V108, P738
NR 10
TC 10
Z9 10
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD JUN
PY 2008
VL 117
IS 6
BP 437
EP 442
PG 6
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 317NG
UT WOS:000257026300006
PM 18646440
ER

PT J
AU Simons, JP
   Ruseetta, MN
   Chi, DH
AF Simons, Jeffrey P.
   Ruseetta, Melissa N.
   Chi, David H.
TI Sensorineural hearing impairment in children with Chiari I malformation
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE Chiari I malformation; hearing loss; pediatrics; sensorineural hearing
   impairment
ID SURGICAL DECOMPRESSION; MANIFESTATIONS
AB Objectives: We describe the prevalance of Chiari I malformation in children presenting to a pediatric tertiary care hearing loss clinic, characterize the phenotype of hearing loss in children with Chiari I malformation, and discuss the potential pathophysiology of sensorineural hearing impairment (SNHI) related to Chiari I malformation.
   Methods: This study was a retrospective case series of patients seen in a pediatric tertiary care hearing loss clinic affiliated with an academic medical center. We considered 491 patients with SNHI who had radiographic imaging as part of the evaluation for the cause of their hearing impairment. Hearing impairment was determined by behavioral audiogram and/or auditory brain stem response testing. Radiographic imaging was performed with computed tomography and/or magnetic resonance imaging.
   Results: Six children with SNHI also had a diagnosis of Chiari I malformation, Four of these 6 children had unilateral hearing impairment. One child had asymmetric bilateral impairment, I child had symmetric bilateral impairment. The severity of hearing impairment varied from mild to profound. All children were referred to the neurosurgery department. None underwent surgical decompression.
   Conclusions. Chiari I malformation may be associated with SNHI. Central nervous system imaging for the evaluation of children with SNHI may be indicated, particularly in individuals with negative results on temporal bone computed tomography and genetic testing.
C1 [Chi, David H.] Childrens Hosp Pittsburgh, Dept Pediat Otolaryngol, Pittsburgh, PA 15213 USA.
   Univ Pittsburgh, Sch Med, Pittsburgh, PA USA.
RP Chi, DH (reprint author), Childrens Hosp Pittsburgh, Dept Pediat Otolaryngol, 3705 5th Ave, Pittsburgh, PA 15213 USA.
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NR 16
TC 2
Z9 4
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD JUN
PY 2008
VL 117
IS 6
BP 443
EP 447
PG 5
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 317NG
UT WOS:000257026300007
PM 18646441
ER

PT J
AU Bhattacharyya, N
   Kepnes, LJ
AF Bhattacharyya, Neil
   Kepnes, Lynn J.
TI Assessment of trends in antimicrobial resistance in chronic
   rhinosinusitis
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE antibiotic therapy; antimicrobial resistance; chronic rhinosinusitis
ID ENDOSCOPIC SINUS SURGERY; MICROBIOLOGY; DIAGNOSIS; MANAGEMENT
AB Objectives: We performed a cross-sectional review of a prospective database to determine the contemporary incidence and temporal patterns of antimicrobial resistance in chronic rhinosinusitis (CRS).
   Methods: A microbiological database was retrospectively reviewed to extract all endoscopically obtained paranasal sinus cultures from 2001 through 2005 in adult patients with CRS. The culture data were tabulated according to bacterial species and representative antibiotic resistances for methicillin, erythromycin, clindamycin, gentamicin, tetracycline, sulfamethoxazole, and levofloxacin. The data were analyzed to determine whether increasing rates of antibiotic resistance developed over the study years. Further analysis was conducted for methicillin-resistant Staphylococcus aureus (MRSA) species to determine prevalence trends and antibiotic resistance trends for MRSA versus other species.
   Results: We analyzed 701 bacterial isolates among 392 culture samples. Staphylococcus aureus was the most commonly isolated organism (19.0%). Antibiotic resistance significantly increased for erythromycin over the study (maximum resistance rate, 69.7% in 2005; p = .009), remained unchanged for methicillin, clindamycin, levofloxacin, and sulfamethoxazole (p = .366 to p = .397), and trended downward for gentamicin (p =. 180) and tetracycline (p =. 120). Nineteen percent of S aureus species were found to be MRSA, but MRSA-specific antibiotic resistance rates did not change over the course of the study (all p >= .222). In aggregate, MRSA species exhibited statistically significant higher rates of resistance to each antibiotic tested than did non-MRSA bacteria.
   Conclusions: Antibiotic resistance seems to be emerging for erythromycin at a rate higher than for other antibiotics. Although not increasing in prevalence, MRSA maintains a significant presence in CRS with associated increased levels of antibiotic resistance.
C1 [Bhattacharyya, Neil; Kepnes, Lynn J.] Brigham & Womens Hosp, Div Otolaryngol, Boston, MA 02115 USA.
   [Bhattacharyya, Neil] Harvard Univ, Sch Med, Dept Otol & Laryngol, Boston, MA 02115 USA.
RP Bhattacharyya, N (reprint author), Brigham & Womens Hosp, Div Otolaryngol, 45 Francis St, Boston, MA 02115 USA.
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   Bhattacharyya Neil, 2002, Curr Allergy Asthma Rep, V2, P500, DOI 10.1007/s11882-002-0091-1
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   Nadel DM, 1998, AM J RHINOL, V12, P233, DOI 10.2500/105065898781390000
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   Siddiqui J, 2004, AM J MED, V117, P26, DOI 10.1016/j.amjmed.2004.07.026
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NR 22
TC 18
Z9 18
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD JUN
PY 2008
VL 117
IS 6
BP 448
EP 452
PG 5
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 317NG
UT WOS:000257026300008
PM 18646442
ER

PT J
AU Suzuki, T
   Kobayashi, K
   Tada, Y
   Suzuki, Y
   Wada, I
   Nakamura, T
   Omori, K
AF Suzuki, Teruhisa
   Kobayashi, Ken
   Tada, Yasuhiro
   Suzuki, Yukie
   Wada, Ikuo
   Nakamura, Tatuo
   Omori, Koichi
TI Regeneration of the trachea using a bioengineered scaffold with
   adipose-derived stem cells
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE adipose-derived stem cells; angiogenesis; neovascularization;
   regeneration; trachea
ID STROMAL CELLS; ENDOTHELIAL-CELLS; ADULT-MOUSE; IN-VITRO; TISSUE; RAT;
   MARROW; DIFFERENTIATION; CARTILAGE; DERMIS
AB Objectives: Our group has developed and clinically applied an artificial graft made from a collagen sponge scaffold for the regeneration of tracheal tissue. However, the artificial graft requires about 2 months for epithelial regeneration. The purpose of the present study was to accelerate the regeneration process of the trachea through the effective use of a bioengineered scaffold. Adipose-derived stem cells (ASCs) with multilineage differentiation capability were used. In our study, we implanted a bioengineered scaffold that included autologous ASCs into tracheal defects in rats.
   Methods: Collagen gel, including ASCs labeled with monomeric yellow fluorescent protein, was layered onto the surface of the collagen sponge to form a bioengineered scaffold. This scaffold was implanted into the tracheal defects in rats. A control scaffold without ASCs was also implanted.
   Results: On day 14 after implantation, a pseudostratified columnar epithelium with well-differentiated ciliated and goblet cells and neovascularization was observed in rats that received the implant with the bioengineered scaffold that included ASCs.
   Conclusions: These results suggested that implanted ASCs accelerated neovascularization and epithelialization on the regenerated trachea. Thus, our newly developed bioengineered scaffold contributes,to tracheal regeneration.
C1 [Suzuki, Teruhisa; Kobayashi, Ken; Tada, Yasuhiro; Suzuki, Yukie; Omori, Koichi] Fukushima Med Univ, Sch Med, Dept Otolaryngol, Fukushima 9601925, Japan.
   [Wada, Ikuo] Fukushima Med Univ, Sch Med, Dept Cell Sci, Inst Biomed Sci, Fukushima 9601925, Japan.
   [Kobayashi, Ken] Keio Univ, Sch Med, Dept Pharmacol, Tokyo 160, Japan.
   [Nakamura, Tatuo] Kyoto Univ, Inst Frontier Med Sci, Dept Bioartificial Organs, Kyoto, Japan.
RP Suzuki, T (reprint author), Fukushima Med Univ, Sch Med, Dept Otolaryngol, 1 Hikarigaoka, Fukushima 9601925, Japan.
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NR 27
TC 30
Z9 36
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD JUN
PY 2008
VL 117
IS 6
BP 453
EP 463
PG 11
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 317NG
UT WOS:000257026300009
PM 18646443
ER

PT J
AU Hoa, M
   Kingsley, EL
   Coticchia, JM
AF Hoa, Michael
   Kingsley, Emily L.
   Coticchia, James M.
TI Correlating the clinical course of recurrent croup with endoscopic
   findings: A retrospective observational study
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE direct laryngoscopy and bronchoscopy; gastroesophageal reflux; reactive
   airway disease; subglottic stenosis; telephone questionnaire
ID GASTROESOPHAGEAL REFLUX DISEASE; LARYNGEAL MANIFESTATIONS; RESPIRATORY
   SYMPTOMS; SUBGLOTTIC STENOSIS; CHILDREN; DIAGNOSIS; INFANTS; ALLERGY;
   ASTHMA
AB Objectives: We sought to correlate endoscopic findings with the clinical course of recurrent croup.
   Methods: Children were classified as having recurrent croup if they had had 2 or more episodes of barky cough, inspiratory stridor, and hoarseness. All study participants underwent direct laryngoscopy and bronchoscopy and were started on an antireflux regimen. A telephone questionnaire assessed the child's symptoms and treatment response.
   Results: Forty-seven children with recurrent croup were seen in our otolaryngology outpatient clinic. Demographics included a male-to-female ratio of 1.6 to 1 and an age range of 1 month to 11 years (median, 20 months). Thirty patients (63.8%) had a medical history of asthma, and 10 (21.3%) came with a prior diagnosis of gastroesophageal reflux. Gastroesophageal reflux-related laryngopharyngeal changes were seen during direct laryngoscopy and bronchoscopy in 87.2%. Of those with survey follow-up, 87.5% had improvement of respiratory symptoms after a 6- to 9-month course of antireflux medications. This finding was further reflected in a decreased number and duration of episodes (p < .0001).
   Conclusions: The underlying narrowing process of recurrent croup can be attributed to gastroesophageal reflux and should be considered in any child with persistent barky cough, inspiratory stridor, and hoarseness. To confirm the diagnosis, diagnostic methods should be correlated with symptom progression after treatment initiation.
C1 [Hoa, Michael; Kingsley, Emily L.; Coticchia, James M.] Wayne State Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, Detroit, MI 48201 USA.
RP Coticchia, JM (reprint author), Wayne State Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, Suite 5E Univ Hlth Ctr,4201 St Antoine, Detroit, MI 48201 USA.
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NR 22
TC 15
Z9 16
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD JUN
PY 2008
VL 117
IS 6
BP 464
EP 469
PG 6
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 317NG
UT WOS:000257026300010
PM 18646444
ER

PT J
AU Lee, DH
   Yeo, SW
   Chang, KH
   Park, SY
   Oh, JH
   Seo, JH
AF Lee, Dong-Hee
   Yeo, Sang-Won
   Chang, Ki-Hong
   Park, So-Young
   Oh, Jeong-Hoon
   Seo, Jae-Hyun
TI Effect of infliximab on experimentally induced otitis media in rats
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE anti-inflammatory agent; infliximab; monoclonal antibody; otitis media;
   rat; tumor necrosis factor alpha
ID NECROSIS-FACTOR-ALPHA; MUCIN GENE-EXPRESSION; MIDDLE-EAR; BARRIER
   BREAKDOWN; INHIBITOR; INDUCTION; EFFUSION
AB Objectives: We performed a prospective randomized and controlled animal study to investigate the effects of infliximab on experimental otitis media in rats.
   Methods: Seventy-two Sprague-Dawley rats were randomly allocated to 3 study groups and 1 control group. Infliximab was injected intravenously. Histopathologic changes were determined by hematoxylin-eosin staining. Fluorescence microscopy was performed to examine the leakage of the exudates. Vascular permeability was measured by the Evans blue dye technique.
   Results: In comparison with the control group, we found significant differences in the extent of middle ear mucosa without active inflammation and the presence of reparable lesions in all study groups treated with infliximab. A significant reduction of extravasated Evans blue dye in all study group animals was found as compared with the control group animals.
   Conclusions: This study suggests that the monoclonal tumor necrosis factor alpha antibody, infliximab, can reduce inflammatory activity in experimental otitis media in rats.
C1 [Lee, Dong-Hee; Yeo, Sang-Won; Chang, Ki-Hong; Park, So-Young; Oh, Jeong-Hoon; Seo, Jae-Hyun] Catholic Univ, Coll Med, Kangnam St Marys Hosp, Dept Otolaryngol Head & Neck Surg, Seoul 137040, South Korea.
RP Yeo, SW (reprint author), Catholic Univ, Coll Med, Kangnam St Marys Hosp, Dept Otolaryngol Head & Neck Surg, 505 Banpo Dong, Seoul 137040, South Korea.
CR Jeon EJ, 2001, ANN OTO RHINOL LARYN, V110, P917
   Kawano H, 2002, ANN OTO RHINOL LARYN, V111, P415
   Kerschner JE, 2004, ARCH OTOLARYNGOL, V130, P1163, DOI 10.1001/archotol.130.10.1163
   Kim DH, 2006, ANN OTO RHINOL LARYN, V115, P617
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   Schousboe LP, 2000, ACTA OTO-LARYNGOL, P89
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NR 13
TC 3
Z9 3
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD JUN
PY 2008
VL 117
IS 6
BP 470
EP 476
PG 7
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 317NG
UT WOS:000257026300011
PM 18646445
ER

PT J
AU Woodson, G
AF Woodson, Gayle
TI Management of neurologic disorders of the larynx
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE larynx; neurologic disorder
ID ADDUCTOR SPASMODIC DYSPHONIA; MULTIPLE SYSTEM ATROPHY; BOTULINUM TOXIN;
   RECURRENT LARYNGEAL; PARKINSONS-DISEASE; SPASTIC DYSPHONIA;
   MYASTHENIA-GRAVIS; ESSENTIAL TREMOR; MUSCLE-ACTIVITY; VOCAL FOLD
AB Objectives: I review the literature on management of neurologic disorders of the larynx.
   Methods: I reviewed the literature on laryngeal physiology, clinical evaluation of laryngeal function, and the clinical presentation and treatment of neurologic disorders that frequently affect the larynx.
   Results: Laryngeal function is complex, as this organ is important in breathing, speech, and swallowing. Coordination of these roles is very susceptible to disruption by neurologic disorders. Diagnosis of neurologic disease is primarily based on history and physical examination; however, the diagnosis of laryngeal dysfunction is frequently overlooked, because the larynx is not easily accessible to examination by non-otolaryngologists. Evaluation of laryngeal function includes listening to the voice, systematic observation of the larynx during speech and nonspeech tasks, and, sometimes, ancillary tests. Neurologic disorders that affect laryngeal function include Parkinson's disease, essential tremor, stroke, amyotrophic lateral sclerosis, multiple sclerosis, and dystonia. The otolaryngologist can sometimes provide treatment to specifically improve symptoms of laryngeal involvement.
   Conclusions: Otolaryngology consultation is important in the diagnosis and treatment of neurologic disorders that affect laryngeal function. The otolaryngologist should be able to perform a systematic evaluation of laryngeal and pharyngeal function, and should be aware of the clinical presentation of neurologic disorders that affect the larynx.
C1 So Illinois Univ, Sch Med, Div Otolaryngol, Dept Surg, Springfield, IL 62794 USA.
RP Woodson, G (reprint author), So Illinois Univ, Sch Med, Div Otolaryngol, Dept Surg, POB 10662, Springfield, IL 62794 USA.
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NR 38
TC 7
Z9 8
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD MAY
PY 2008
VL 117
IS 5
BP 317
EP 326
PG 10
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 302KD
UT WOS:000255966300001
PM 18564527
ER

PT J
AU Ridgway, JM
   Su, JP
   Wright, R
   Guo, SG
   Kim, DC
   Barretto, R
   Ahuja, G
   Sepehr, A
   Perez, J
   Sills, JH
   Chen, ZP
   Wong, BJF
AF Ridgway, James M.
   Su, Jianping
   Wright, Ryan
   Guo, Shuguang
   Kim, David C.
   Barretto, Roberto
   Ahuja, Gurpreet
   Sepehr, Ali
   Perez, Jorge
   Sills, Jack H.
   Chen, Zhongping
   Wong, Brian J. F.
TI Optical coherence tomography of the newborn airway
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT 87th Annual Meeting of the American-Broncho-Esophagological-Association
CY APR 26-27, 2007
CL San Diego, CA
SP Amer Broncho Esophagol Assoc
DE imaging; newborn airway; optical coherence tomography; subglottic
   stenosis
ID SUBGLOTTIC STENOSIS; BLOOD-FLOW; HUMAN SKIN; VELOCITY; INFANTS
AB Objectives: Acquired subglottic stenosis in a newborn is often associated with prolonged endotracheal intubation. This condition is generally diagnosed during operative endoscopy after airway injury has occurred. Unfortunately, endoscopy is unable to characterize the submucosal changes observed in such airway injuries. Other modalities, such as magnetic resonance imaging, computed tomography, and ultrasound, do not possess the necessary level of resolution to differentiate scar, neocartilage, and edema. Optical coherence tomography (OCT) is an imaging modality that produces high-resolution, cross-sectional images of living tissue (8 to 20 pm). We examined the ability of this noninvasive technique to characterize the newborn airway in a prospective clinical trial.
   Methods: Twelve newborn patients who required ventilatory support underwent OCT airway imaging. Comparative analysis of intubated and non-intubated states was performed.
   Results: Imaging of the supraglottis, glottis, subglottis, and trachea was performed in 12 patients, revealing unique tissue characteristics as related to turbidity, signal backscattering, and architecture. Multiple structures were identified, including the vocal folds, cricoid cartilage, tracheal rings, ducts, glands, and vessels.
   Conclusions: Optical coherence tomography clearly identifies in vivo tissue layers and regional architecture while offering detailed information concerning tissue micro structures. The diagnostic potential of this technology makes OCT a promising modality in the study and surveillance of the neonatal airway.
C1 [Ridgway, James M.; Su, Jianping; Wright, Ryan; Guo, Shuguang; Sepehr, Ali; Perez, Jorge; Chen, Zhongping; Wong, Brian J. F.] Univ Calif Irvine, Beckman Laser Inst, Irvine, CA 92612 USA.
   [Ridgway, James M.; Barretto, Roberto; Ahuja, Gurpreet; Sepehr, Ali; Wong, Brian J. F.] Univ Calif Irvine, Dept Otolaryngol Head & Neck Surg, Irvine, CA 92612 USA.
   [Su, Jianping; Guo, Shuguang; Chen, Zhongping; Wong, Brian J. F.] Univ Calif Irvine, Dept Biomed Engn, Irvine, CA 92612 USA.
   [Kim, David C.; Sills, Jack H.] Univ Calif Irvine, Dept Pediat, Irvine, CA 92612 USA.
RP Wong, BJF (reprint author), Univ Calif Irvine, Beckman Laser Inst, 1002 Hlth Sci Rd, Irvine, CA 92612 USA.
EM bjwong@uci.edu
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   Walner DL, 1998, ARCH OTOLARYNGOL, V124, P551
   Wong B, 2006, LARYNGOSCOPE, V116, P507
   Wong BJF, 2004, OTOLARYNG HEAD NECK, V130, P458
   Wong BJF, 2000, J BIOMED OPT, V5, P367, DOI 10.1117/1.1310165
   Zhao YH, 2000, OPT LETT, V25, P114, DOI 10.1364/OL.25.000114
NR 20
TC 17
Z9 17
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD MAY
PY 2008
VL 117
IS 5
BP 327
EP 334
PG 8
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 302KD
UT WOS:000255966300002
PM 18564528
ER

PT J
AU van der Avoort, SJC
   van Heerbeek, N
   Admiraal, RJC
   Zielhuis, GA
   Cremers, CWRJ
AF van der Avoort, Stijn J. C.
   van Heerbeek, Niels
   Admiraal, Ronald J. C.
   Zielhuis, Gerhard A.
   Cremers, Cor W. R. J.
TI Results of sonotubometry in testing eustachian tube ventilatory function
   in children with cleft palate
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE cleft palate; eustachian tube; sonotubometry
ID OTITIS-MEDIA; MIDDLE-EAR; HEALTHY-CHILDREN; AUDITORY TUBE; EFFUSION;
   PATHOGENESIS; ADULTS; PALATOPLASTY; RELIABILITY; NOISE
AB Objectives: In previous studies, an updated sonotubometry setup was tested in healthy adults and children to test its validity and reproducibility in the assessment of the ventilatory function of the eustachian tube (ET). The results were promising, but further investigations were needed to confirm the discriminative potential of this sonotubometry setup. Our objective in the present study was to test the discriminative potential of an updated sonotubometry setup in children with cleft palate.
   Methods: The ET ventilatory function was tested in 56 children with cleft palate, ie, children with impaired ET function, and compared to the outcomes in 61 healthy children who served as a control group. All of the children were between 5 and 9 years of age. To test the reproducibility, we performed the sonotubometric testing in 2 sessions of 10 acts of swallowing each. Spearman's coefficient was used to test the correlation between the 2 sets of measurements. The results of measurements in the cleft palate group were compared with those in the otologically healthy control group and analyzed by means of a Mann-Whitney U test.
   Results: Opening of the ET was recorded in at least 1 of the 2 measurement sessions in 57% of the children with cleft palate, as compared to 82% in the control group. The mean number of openings was lower in the cleft palate group than in the control group (respectively, 2.3 versus 3.7 out of 10; p < .01). The first and second sessions were highly correlated in both the cleft palate group and the control group, with Spearman's coefficients of, respectively, 0.96 and 0.89.
   Conclusions: The results of this study show that this updated sonotubometry setup has the potential to discriminate between these groups of children with various states of ET ventilatory function. Furthermore, the results of this study once again show that this updated sonotubometry setup is capable of assessing ET ventilatory function in both healthy children and children with cleft palate and that the measurements are highly reproducible. A persistent disadvantage remains that in 18% of the 61 healthy children there was no ET opening that could be registered, which still prohibits a definite assessment at the individual level.
C1 [van der Avoort, Stijn J. C.; van Heerbeek, Niels; Admiraal, Ronald J. C.; Cremers, Cor W. R. J.] Radboud Univ Nijmegen, Med Ctr, Dept Otorhinolaryngol, NL-6500 HB Nijmegen, Netherlands.
   [Zielhuis, Gerhard A.] Radboud Univ Nijmegen, Med Ctr, Dept Epidemiol & Biostat, NL-6500 HB Nijmegen, Netherlands.
RP van der Avoort, SJC (reprint author), Radboud Univ Nijmegen, Med Ctr, Dept Otorhinolaryngol, Philips van Leydenlaan 15,POB 9101, NL-6500 HB Nijmegen, Netherlands.
RI Zielhuis, Gerhard/H-8123-2014
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NR 39
TC 1
Z9 1
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD MAY
PY 2008
VL 117
IS 5
BP 335
EP 340
PG 6
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 302KD
UT WOS:000255966300003
PM 18564529
ER

PT J
AU Lin, J
   Staecker, H
   Jafri, MS
AF Lin, James
   Staecker, Hinrich
   Jafri, M. Samir
TI Optical coherence tomography imaging of the inner ear: A feasibility
   study with implications for cochlear implantation
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE cochlear implantation; electrical acoustic hearing; optical coherence
   tomography; round window membrane
ID RESIDUAL HEARING; ELECTRODE INSERTION; PRESERVATION; SURGERY; DESIGN;
   TRAUMA; MODEL
AB Cochlear implantation is now being performed in ears with residual hearing. Those implant recipients who keep residual hearing may benefit from improved pitch resolution through both electrical and acoustic hearing. Preservation of cochlear function after implantation is a challenging task for the surgeon. Current topics of hearing preservation research include electrode design and surgical technique. To maintain hearing, surgeons strive to create a cochleostomy and place the electrode in a minimally traumatic fashion. In this study, we examine a novel catheter-based real-time imaging modality with 10- to 15-mu m resolution, optical coherence tomography (OCT), on the inner ear. We demonstrate the capability of OCT to allow visualization of inner ear structures through bone in live mice. We additionally used OCT to image the inner ear in a human temporal bone. Optical coherence tomography was able to delineate soft tissue structures within the cochlea and may be useful as an adjunct to cochlear implantation. Other potential otologic applications of OCT are discussed.
C1 [Lin, James] Univ Maryland, Sch Med, Dept Otorhinolaryngol Head & Neck Surg, Baltimore, MD 21201 USA.
   [Jafri, M. Samir] Univ Maryland, Sch Med, Dept Neurol, Baltimore, MD 21201 USA.
   [Jafri, M. Samir] Dept Vet Affairs Med Ctr, Res Serv, Baltimore, MD USA.
   [Staecker, Hinrich] Univ Kansas, Med Ctr, Dept Otolaryngol Head & Neck Surg, Kansas City, KS 66103 USA.
RP Lin, J (reprint author), House Ear Clin, 2100 W 3rd St, Los Angeles, CA 90057 USA.
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NR 26
TC 15
Z9 15
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD MAY
PY 2008
VL 117
IS 5
BP 341
EP 346
PG 6
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 302KD
UT WOS:000255966300004
PM 18564530
ER

PT J
AU Lee, HM
   Cho, JG
   Kang, HJ
   Chae, SW
   Hwang, SJ
   Jung, KY
   Woo, JS
AF Lee, Heung-Man
   Cho, Jae-Goo
   Kang, Hee-Joon
   Chae, Sung-Won
   Hwang, Soon-Jae
   Jung, Kwang-Yoon
   Woo, Jeong-Soo
TI Expression of oncostatin M in chronic obstructive sialadenitis of the
   submandibular gland
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE oncostatin M; sialadenitis
ID CELLS; CYTOKINES; NEUTROPHILS; GP130
AB Objectives: We investigated the expression of oncostatin M messenger RNA (mRNA) and protein in normal submandibular glands and those with chronic obstructive sialadenitis and localized the expression of oncostatin M protein.
   Methods: Submandibular glands from 10 patients with chronic obstructive sialadenitis as a study group and 10 normal submandibular glands as a control group were examined. Oncostatin M mRNA extracted from submandibular gland was used for reverse transcription-polymerase chain reaction and analyzed semiquantitatively. The difference in expression level of oncostatin M protein between the 2 groups was analyzed through Western blot analysis, and oncostatin M protein was localized immunohistochemically.
   Results: The expression levels of oncostatin M mRNA and protein were significantly increased in the study group. The protein was predominantly localized in ductal epithelia and infiltrating inflammatory cells and was more strongly expressed in the study group also.
   Conclusions: Oncostatin M is expressed in both chronic obstructive sialadenitis and normal submandibular gland, and is up-regulated in chronic obstructive sialadenitis. These results suggest that oncostatin M is involved in the pathologic process of chronic obstructive sialadenitis. However, the physiologic role in normal glands, as well as a possible role in the development of chronic obstructive sialadenitis, remains to be elucidated.
C1 [Lee, Heung-Man; Cho, Jae-Goo; Kang, Hee-Joon; Chae, Sung-Won; Hwang, Soon-Jae; Jung, Kwang-Yoon; Woo, Jeong-Soo] Korea Univ, Coll Med, Dept Otolaryngol Head & Neck Surg, Guro Hosp, Seoul 152703, South Korea.
RP Woo, JS (reprint author), Korea Univ, Coll Med, Dept Otolaryngol Head & Neck Surg, Guro Hosp, 80 Gurodong, Seoul 152703, South Korea.
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NR 22
TC 0
Z9 0
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD MAY
PY 2008
VL 117
IS 5
BP 347
EP 352
PG 6
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 302KD
UT WOS:000255966300005
PM 18564531
ER

PT J
AU Ivey, CM
   Woo, P
   Altman, KW
   Shapshay, SM
AF Ivey, Chandra M.
   Woo, Peak
   Altman, Kenneth W.
   Shapshay, Stanley M.
TI Office pulsed dye laser treatment for benign laryngeal vascular polyps:
   A preliminary study
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT Meeting of the American-Laryngological-Association
CY APR 26-27, 2007
CL San Diego, CA
SP Amer Laryngol Assoc
DE pulsed dye laser; vascular polyp
ID COAGULATION; DAMAGE; DEPTH
AB Objectives: The 585-nm pulsed dye laser (PDL) was recently deemed relatively safe and effective for treatment of laryngeal papilloma, dysplasia, and granuloma. We report on in-office PDL treatment of laryngeal vascular polyps.
   Methods: Retrospective case results from 29 consecutive cases of laryngeal polyps were evaluated to determine the percent change in polyps after PDL treatment. Preoperative and postoperative measurements of polyp size, total power delivered to the site, and whether patients opted for postprocedure phonomicrosurgery were analyzed.
   Results: After PDL treatment, the results varied from complete to partial resolution of the polyp. Four patients requested conventional phonomicrosurgery, and the rest had enough improvement to defer surgery. Almost 40% of patients with larger polyps desired operative intervention after laser treatment, whereas only 13% of those with small polyps opted for phonomicrosurgery. Thirty-eight percent (11 of 29) of the lesions had greater than 70% improvement after 1 or 2 laser treatments (average of 1.1 procedures). Smaller lesions responded better. Thirty-nine percent of small polyps resolved by greater than 70%, whereas only 20% of larger lesions improved by the same amount. There were no adverse events from the office procedure.
   Conclusions: In-office use of the PDL for treatment of vascular polyps may be a safe alternative to phonomicrosurgery. Small polyps seem to show a better response.
C1 [Ivey, Chandra M.; Woo, Peak; Altman, Kenneth W.] Mt Sinai Sch Med, Dept Otolaryngol, New York, NY 10029 USA.
   [Shapshay, Stanley M.] Albany Med Coll, Div Otolaryngol, Albany, NY 12208 USA.
RP Ivey, CM (reprint author), Mt Sinai Sch Med, Dept Otolaryngol, 1 Gustave L Levy Pl 1653, New York, NY 10029 USA.
CR Babilas P, 2005, J INVEST DERMATOL, V125, P343, DOI 10.1111/j.0022-202X.2005.23773.x
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NR 12
TC 6
Z9 6
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD MAY
PY 2008
VL 117
IS 5
BP 353
EP 358
PG 6
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 302KD
UT WOS:000255966300006
PM 18564532
ER

PT J
AU Tada, Y
   Suzuki, T
   Takezawa, T
   Nomoto, Y
   Kobayashi, K
   Nakamura, T
   Omori, K
AF Tada, Yasuhiro
   Suzuki, Teruhisa
   Takezawa, Toshiaki
   Nomoto, Yukio
   Kobayashi, Ken
   Nakamura, Tatuo
   Omori, Koichi
TI Regeneration of tracheal epithelium utilizing a novel bipotential
   collagen scaffold
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT Meeting of the American-Laryngological-Association
CY APR 26-27, 2007
CL San Diego, CA
SP Amer Laryngol Assoc
DE bipotential collagen scaffold; collagen vitrigel; trachea
   reconstruction; tracheal epithelium
AB Objectives: The purpose of the present study was to evaluate the effectiveness of a novel bipotential collagen scaffold as a bioengineered trachea for the regeneration of the tracheal epithelium.
   Methods: The bipotential collagen scaffold was developed by conjugating a collagen vitrigel membrane to a collagen sponge in order to promote both epithelial cell growth and mesenchymal cell infiltration. The bipotential collagen scaffold was transplanted into tracheal defects in rats, and a conventional collagen sponge was implanted as a control model. Histologic examinations were undertaken to evaluate the results.
   Results: The bioengineered trachea was covered with epithelium in the vitrigel model, but not in the control model, at 7 days after implantation. At 14 days after implantation, the bioengineered trachea was covered with epithelium involving the basal cell layer in the vitrigel model. At 28 days after implantation, a columnar ciliated epithelium was observed only in the vitrigel model.
   Conclusions: Our technique for trachea reconstruction using a novel bipotential collagen scaffold affords a feasible approach for accelerating epithelial regeneration on the intraluminal surface of the host tracheal defect.
C1 [Tada, Yasuhiro; Suzuki, Teruhisa; Nomoto, Yukio; Kobayashi, Ken; Omori, Koichi] Fukushima Med Univ, Dept Otolaryngol, Sch Med, Fukushima 9601295, Japan.
   [Takezawa, Toshiaki] Natl Inst Agrobiol Sci, Transgen Anim Res Ctr, Tsukuba, Ibaraki, Japan.
   [Nakamura, Tatuo] Kyoto Univ, Dept Bioartificial Organs, Inst Frontier Med Sci, Kyoto, Japan.
RP Tada, Y (reprint author), Fukushima Med Univ, Dept Otolaryngol, Sch Med, 1 Hikarigaoka, Fukushima 9601295, Japan.
CR Kanemaru SI, 2003, ANN OTO RHINOL LARYN, V112, P915
   Kobayashi K, 2006, TISSUE ENG, V12, P2619, DOI 10.1089/ten.2006.12.2619
   LANGER R, 1993, SCIENCE, V260, P920, DOI 10.1126/science.8493529
   Nakamura T, 2000, INT J ARTIF ORGANS, V23, P718
   Nomoto Y, 2006, ANN OTO RHINOL LARYN, V115, P501
   Omori K, 2005, ANN OTO RHINOL LARYN, V114, P429
   Takezawa T, 2004, CELL TRANSPLANT, V13, P463, DOI 10.3727/000000004783983882
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NR 10
TC 14
Z9 14
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD MAY
PY 2008
VL 117
IS 5
BP 359
EP 365
PG 7
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 302KD
UT WOS:000255966300007
PM 18564533
ER

PT J
AU Pessin, AB
   Martins, RHG
   Pimenta, WD
   Simoes, ACP
   Marsiglia, A
   Amaral, AV
AF Benito Pessin, Adriana Bueno
   Garcia Martins, Regina Helena
   Pimenta, Walkyiria de Paula
   Pereira Simoes, Antonio Caetano
   Marsiglia, Alessandra
   Amaral, Amanda Vieira
TI Auditory evaluation in patients with type 1 diabetes
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
ID HEARING-LOSS; INNER-EAR; PERIPHERAL NEUROPATHY; MELLITUS; PATHWAY
AB Objectives: We performed a prospective clinical study of the cochleovestibular symptoms and the risk cofactors and characteristics of hearing loss in patients with type 1 diabetes.
   Methods: Group I consisted of 40 patients with type I diabetes, and group 2 consisted of 20 control subjects without diabetes. All participants answered a questionnaire, and their medical records were reviewed. They also were submitted to otorhinolaryngological examinations and to auditory tests (pure tone audiometry and acoustic immitance and auditory brain stem response [ABR] tests).
   Results: Dyslipidemia, hypertension, retinopathy, and diabetic neuropathy were not frequent in the patients of group 1, but incipient nephropathy was present in 47.5% of them. The most frequent cochleovestibular symptoms were tinnitus and hearing loss. Sensorineural hearing loss was found in 4 patients of group I and was predominantly bilateral, symmetric, and affecting the high frequencies, coexisting with normal vocal discrimination. These patients had a longer time from diabetes diagnosis and had poor glycemia control. A delay of ABR interpeak latency I-III was observed in 11.25% of the group I ears. All patients of group 2 presented normal audiograms and ABR tests.
   Conclusions: In group 1, the most frequent cochleovestibular symptoms were tinnitus and hearing loss. The sensorineural hearing loss was mild, symmetric, and predominantly high-frequency. A delay of ABR interpeak latencies was detected in the patients of group I who had normal audiometric thresholds.
C1 [Benito Pessin, Adriana Bueno; Garcia Martins, Regina Helena; Marsiglia, Alessandra; Amaral, Amanda Vieira] Sao Paulo State Univ, Sch Med, Fac Med Botucatu, Disciplina Otorrinolaringol,Dept Oftalmol Otorino, BR-18618970 Botucatu, SP, Brazil.
   [Pimenta, Walkyiria de Paula] Sao Paulo State Univ, Sch Med, Dept Internal Med, BR-18618970 Botucatu, SP, Brazil.
   [Pereira Simoes, Antonio Caetano] Sao Paulo State Univ, Sch Med, Dept Pediat, BR-18618970 Botucatu, SP, Brazil.
RP Martins, RHG (reprint author), Sao Paulo State Univ, Sch Med, Fac Med Botucatu, Disciplina Otorrinolaringol,Dept Oftalmol Otorino, Distrito Rubiao Jr S-N, BR-18618970 Botucatu, SP, Brazil.
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NR 29
TC 14
Z9 18
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD MAY
PY 2008
VL 117
IS 5
BP 366
EP 370
PG 5
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 302KD
UT WOS:000255966300008
PM 18564534
ER

PT J
AU Hahn, MS
   Jao, CY
   Faquin, W
   Grande-Allen, KJ
AF Hahn, Mariah S.
   Jao, Cindy Y.
   Faquin, William
   Grande-Allen, K. Jane
TI Glycosaminoglycan composition of the vocal fold lamina propria in
   relation to function
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE fluorophore-assisted carbohydrate electrophoresis; glycosaminoglycan;
   lamina propria; proteoglycan; scarring; vocal fold
ID SMOOTH-MUSCLE-CELLS; EXTRACELLULAR-MATRIX; HYALURONIC-ACID; ELASTIC
   FIBERS; KERATAN SULFATE; PG-M/VERSICAN; PROTEOGLYCANS; COLLAGEN;
   CARTILAGE; TISSUES
AB Objectives: This study was designed to quantify the specific glycosaminoglycans (GAGs) in the midmembranous vocal fold (VF) lamina propria (LP) and to interpret their presence in relation to the known stresses borne by each LP layer.
   Methods: GAGs from normal human LP and from both normal and scarred canine LPs were analyzed by fluorophore-assisted carbohydrate electrophoresis (FACE). Immunostaining was conducted to give insight into the spatial distribution of each GAG type.
   Results: Hyaluronan composes roughly 0.64%+/- 0.41% of the human LP as measured relative to tissue total protein. Chondroitin sulfate and/or dermatan sulfate (CS/DS), keratan sulfate, and heparan sulfate chains constitute approximately 23.9%+/- 12.1%, 14.7%+/- 6. 1 %, and 61.4%+/- 13.6%, respectively, of human LP sulfated GAGs.
   Conclusions: Observed CS/DS sulfation patterns imply that versican is a major contributor to human LP CS levels. In addition, examination of LP GAG with respect to gender revealed a significant variation in total levels of CS/DS and a potential difference in the levels of versican relative to decorin and biglycan. In dogs, LP scarring appeared to result in a reduction in hyaluronan and CS/DS. These FACE results were combined with histologic data to update current descriptive models linking LP microstructure with the regional variations in LP loading.
C1 [Hahn, Mariah S.] Texas A&M Univ, Dept Chem Engn, College Stn, TX 77843 USA.
   [Grande-Allen, K. Jane] Rice Univ, Dept Bioengn, Houston, TX 77251 USA.
   [Jao, Cindy Y.] MIT, Dept Chem Engn, Cambridge, MA 02139 USA.
   [Faquin, William] Massachusetts Gen Hosp, Div ENT Pathol & Cytopathol, Boston, MA 02114 USA.
RP Hahn, MS (reprint author), 200 Jack E Brown Bldg,3122 TAMU, College Stn, TX 77843 USA.
RI Grande-Allen, Kathryn/P-4042-2014
OI Grande-Allen, Kathryn/0000-0003-1533-3767
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NR 51
TC 10
Z9 11
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD MAY
PY 2008
VL 117
IS 5
BP 371
EP 381
PG 11
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 302KD
UT WOS:000255966300009
PM 18564535
ER

PT J
AU Debnath, I
   Rich, JT
   Paniello, RC
AF Debnath, Indranil
   Rich, Jason T.
   Paniello, Randal C.
TI Intrinsic laryngeal muscle reinnervation using the muscle-nerve-muscle
   technique
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT Meeting of the American-Laryngological-Association
CY APR 26-27, 2007
CL San Diego, CA
SP Amer Laryngol Assoc
DE dog; larynx; nerve; reinnervation; vocal cord paralysis
ID NEUROTIZATION
AB Objectives: This study was performed to investigate the muscle-nerve-muscle reinnervation technique in the larynx, in which a nerve conduit implanted into an innervated muscle conducts axonal sprouting into a denervated muscle while maintaining function of the donor muscle.
   Methods: In this study, the muscle-nerve-muscle technique was used to direct superior laryngeal nerve axons to reinnervate intrinsic laryngeal muscles by implanting the recurrent laryngeal nerve stump into the cricothyroid muscle in 8 dogs. In 4 of the dogs, the recurrent laryngeal nerve trunk to the adductor muscles was divided so that all axonal sprouting was directed to the posterior cricoarytenoid muscle. Six-month electromyography data were obtained from 6 of the 8 dogs.
   Results: All 6 dogs showed evidence of successful reinnervation of the thyroarytenoid or posterior cricoarytenoid muscles with action potentials that corresponded to spontaneous respiratory efforts, while the donor cricothyroid muscles retained their phasic contraction. These responses were obliterated when the recurrent laryngeal nerve conduit was divided. Histologic examination of the intrinsic laryngeal muscles demonstrated successful reinnervation.
   Conclusions: The results confirm that intrinsic laryngeal muscles may be successfully reinnervated by the superior laryngeal nerve with the muscle-nerve-muscle technique, without sacrifice of function of the cricothyroid muscle. This method offers an alternative source of appropriately firing axons for laryngeal reinnervation procedures.
C1 [Debnath, Indranil; Rich, Jason T.; Paniello, Randal C.] Washington Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, St Louis, MO 63110 USA.
RP Paniello, RC (reprint author), Washington Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, 660 S Euclid Ave,Box 8115, St Louis, MO 63110 USA.
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NR 16
TC 2
Z9 3
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD MAY
PY 2008
VL 117
IS 5
BP 382
EP 388
PG 7
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 302KD
UT WOS:000255966300010
PM 18564536
ER

PT J
AU Sutbeyaz, Y
   Aktan, B
   Yoruk, O
   Ozdemir, H
   Gundogdu, C
AF Sutbeyaz, Yavuz
   Aktan, Buelent
   Yoruk, Ozgur
   Ozdemir, Hasan
   Gundogdu, Cemal
TI Treatment of sinusitis with corticosteroids in combination with
   antibiotics in experimentally induced rhinosinusitis
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE antibiotic; corticosteroid; rabbit; sinusitis; therapy
ID FUROATE NASAL SPRAY; MAXILLARY SINUSITIS; INFLAMMATORY RESPONSE;
   THERAPY; MUCOSA; BACTERIOLOGY; AMOXICILLIN; ADULTS
AB Objectives: The objective of this study was to investigate the effects of corticosteroids, antibiotics, and their combination in the therapy of experimental bacterial rhinosinusitis.
   Methods: Twenty-eight rabbits underwent experimental induction of bacterial rhinosinusitis with Staphylococcus aureus. The animals were assigned randomly to 1 of 4 treatments (saline solution, methylprednisolone, cefazolin sodium, methylprednisolone-cefazolin sodium) for 7 days. After the treatment period, sinus mucosa samples of the animals were examined stereologically. In addition, mucosa samples were used in the determination of myeloperoxidase (MPO) activity.
   Results: Methylprednisolone, cefazolin, and methylprednisolone-cefazolin had a positive effect on the reduction of neutrophil infiltration to the sinus mucosa in experimental bacterial rhinosinusitis as compared to the group treated with saline solution. However, the effects of methylprednisolone, cefazolin, and methylprednisolone-cefazolin did not significantly differ (p > .05). Similarly, the use of methylprednisolone, cefazolin, and methylprednisolone-cefazolin decreased MPO activity as compared to the group with saline solution (p < .05), and the difference among methylprednisolone, cefazolin, and methylprednisolone-cefazolin was statistically significant (p < .05). The most significant decrease in MPO (neutrophil marker enzyme) activity was determined in the animals treated with methylprednisolone-cefazolin (p < .05).
   Conclusions: Administering corticosteroids as an adjunct to antibiotics may accelerate the healing process in experimentally induced rhinosinusitis. In this model of rhinosinusitis, an MPO assay was supportive of this hypothesis, although stereological examination showed no statistically significant difference.
C1 [Sutbeyaz, Yavuz; Aktan, Buelent; Yoruk, Ozgur] Ataturk Univ, Tip Fak, KBB Anabilim Dali, Dept Otorhinolaryngol Head & Neck Surg,Sch med, TR-25240 Erzurum, Turkey.
   [Gundogdu, Cemal] Ataturk Univ, Sch Med, Dept Pathol, TR-25240 Erzurum, Turkey.
   [Ozdemir, Hasan] Ataturk Univ, Fac Arts & Sci, Dept Chem, TR-25240 Erzurum, Turkey.
RP Sutbeyaz, Y (reprint author), Ataturk Univ, Tip Fak, KBB Anabilim Dali, Dept Otorhinolaryngol Head & Neck Surg,Sch med, TR-25240 Erzurum, Turkey.
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NR 20
TC 4
Z9 4
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD MAY
PY 2008
VL 117
IS 5
BP 389
EP 394
PG 6
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 302KD
UT WOS:000255966300011
PM 18564537
ER

PT J
AU Remade, M
   Lawson, G
   Nollevaux, MC
   Delos, M
AF Remade, Marc
   Lawson, Georges
   Nollevaux, Marie-Cecile
   Delos, Monique
TI Current state of scanning micromanipulator applications with the carbon
   dioxide laser
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT 87th Annual Meeting of the American-Broncho-Esophagological-Association
CY APR 26-27, 2007
CL San Diego, CA
SP Amer Broncho Esophagol Assoc
DE carbon dioxide laser-assisted phonosurgery; robotic scanning
   application; vocal fold
ID VOCAL FOLD LESIONS; CO2 LASER; MICROSURGERY
AB Objectives: The development of the scanning system AcuBlade has considerably enhanced carbon dioxide laser energy delivery, improving cutting and ablation modes. The scanning system can be applied with the 2 available high-powered pulsed waves, SuperPulse and UltraPulse. This study was conducted to determine whether there are any differences in phonosurgery between the SuperPulse and UltraPulse lasing applications with regard to thermal diffusion into the surrounding tissues, healing time, and clinical results.
   Methods: Thirteen patients with bilateral and similar vocal fold lesions underwent operation - one side in SuperPulse mode and the other side in UltraPulse mode. The parameters for phonosurgery were depth of 0.2 mm, 10 W, single pulse, and 0.10 second for SuperPulse, and 2 passes, 10 W, single pulse, and 0.10 second for UltraPulse.
   Results: Incisions were sharper with UltraPulse, making the surgery easier, but at the first postoperative follow-up visit, after 8 to 10 days, no differences were observed in the presentation, the healing, or the vibration of the 2 vocal folds. Coagulation along the incision line was 25 pm for SuperPulse and 15 pm for UltraPulse (median values).
   Conclusions: In comparison with SuperPulse, the UltraPulse carbon dioxide laser made the procedure easier, but did not improve the clinical outcome.
C1 [Remade, Marc; Lawson, Georges] Univ Hosp Louvain Mont Godinne, Dept Otorhinolaryngol Head & Neck Surg, B-5530 Yvoir, Belgium.
   [Nollevaux, Marie-Cecile; Delos, Monique] Univ Hosp Louvain Mont Godinne, Dept Pathol, B-5530 Yvoir, Belgium.
RP Remade, M (reprint author), Univ Hosp Louvain Mont Godinne, Dept Otorhinolaryngol Head & Neck Surg, Ave Therasse 1, B-5530 Yvoir, Belgium.
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PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD APR
PY 2008
VL 117
IS 4
BP 239
EP 244
PG 6
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 288JU
UT WOS:000254983500001
PM 18478831
ER

PT J
AU Capaccio, P
   Cuccarini, V
   Ottaviani, F
   Minorati, D
   Sambataro, G
   Cornalba, P
   Pignataro, L
AF Capaccio, Pasquale
   Cuccarini, Valeria
   Ottaviani, Francesco
   Minorati, Davide
   Sambataro, Giuseppe
   Cornalba, Paolo
   Pignataro, Lorenzo
TI Comparative ultrasonographic, magnetic resonance sialographic, and
   videoendoscopic assessment of salivary duct disorders
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE magnetic resonance sialography; salivary duct stenosis; sialoendoscopy;
   ultrasonography
ID DIGITAL SUBTRACTION SIALOGRAPHY; MR SIALOGRAPHY; CONVENTIONAL
   SIALOGRAPHY; VIRTUAL ENDOSCOPY; GLANDS; DIAGNOSIS; SIALOLITHIASIS;
   SIALADENITIS; SONOGRAPHY; STENOSIS
AB Objectives: Salivary duct disorders are the second most common cause of obstruction after calculi. Magnetic resonance sialography has been recently proposed as a means of diagnosing a heterogeneous group of salivary disorders, and so we compared it with sialoendoscopy in evaluating stenoses and sialectasia in 24 patients with obstructive symptoms and ultrasonographic results negative for calculi or masses.
   Methods: All of the patients (19 of whom had recurrent unilateral or bilateral swollen parotid glands and 5 of whom also had recurrent swollen submandibular glands) underwent dynamic color Doppler ultrasonography and dynamic magnetic resonance sialography with lemon juice stimulation of saliva; 18 patients also underwent diagnostic sialoendoscopy.
   Results: Ultrasonography and color Doppler ultrasonography showed duct dilatation in all patients (bilateral in 5 with parotid stenosis). Magnetic resonance sialography confirmed duct dilatation and stenosis in all of the patients, and revealed the simultaneous presence of calculi in 4 cases. A parotid sialocele was found in 4 cases. The magnetic resonance sialographic findings were confirmed in the patients who underwent sialoendoscopy. No side effects were observed.
   Conclusions: Magnetic resonance sialography following prediagnostic ultrasonography allows an adequate diagnosis of salivary duct disorders such as stenosis and sialectasia, as confirmed by objective sialoendoscopic assessment. Magnetic resonance sialography also makes it possible to visualize the salivary duct system up to its tertiary branches and, in this regard, may be considered a valid, noninvasive method for the evaluation of salivary duct disorders.
C1 [Capaccio, Pasquale; Sambataro, Giuseppe; Pignataro, Lorenzo] Univ Milan, IRCCS, Policlin Fdn, Dept Otorhinolaryngol & Ophthalmol Sci, I-20122 Milan, Italy.
   [Cuccarini, Valeria; Ottaviani, Francesco] Univ Milan, Dept Clin Sci, Div Otorhinolaryngol, I-20122 Milan, Italy.
   [Minorati, Davide] Univ Milan, Dept Radiol, I-20122 Milan, Italy.
   [Cornalba, Paolo] Univ Milan, L Sacco Hosp Vialba, I-20122 Milan, Italy.
   [Cornalba, Paolo] Univ Milan, Dept Radiol Sci, S Paolo Hosp, I-20122 Milan, Italy.
RP Capaccio, P (reprint author), Univ Milan, IRCCS, Policlin Fdn, Dept Otorhinolaryngol & Ophthalmol Sci, Via F Sforza 35, I-20122 Milan, Italy.
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NR 26
TC 7
Z9 7
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD APR
PY 2008
VL 117
IS 4
BP 245
EP 252
PG 8
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 288JU
UT WOS:000254983500002
PM 18478832
ER

PT J
AU Almeida, ST
   Ferlin, EL
   Parente, MAMP
   Goldani, HAS
AF Almeida, Sheila T.
   Ferlin, Elton L.
   Parente, Maria Alice M. P.
   Goldani, Helena A. S.
TI Assessment of swallowing sounds by digital cervical auscultation in
   children
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE child; cervical auscultation; oropharyngeal dysphagia
ID DYSPHAGIA; INFANTS; DEGLUTITION; RELIABILITY; ASPIRATION; GENDER; CARE
AB Objectives: There is a lack of studies regarding swallowing sounds in children 3 to 11 years of age. This study aimed to assess swallowing sounds by digital cervical auscultation in children of this age group without symptoms of oropharyngeal dysphagia.
   Methods: Digital cervical auscultation was performed in 118 subjects by use of a piezoelectric microphone. The children swallowed 5 mL of liquid and yogurt. The components of perceptual acoustic analysis were discrete initial signal (DIS), main signal of swallowing sound (MS), discrete final signal (DFS), and expiratory return (ER). Duration in seconds was the objective parameter of the swallowing sound signal analyzed.
   Results: Fifty-six boys and 62 girls were evaluated at a mean ( SD) age of 6.9 +/- 2.03 years. A complete DIS-MS-DFS-ER swallowing sequence was found in 60% of the children. There was no significant difference in swallowing sound duration between both food consistencies (p = .189) or between genders either for liquid (p = .327) or yogurt (p = .792). There was no correlation between age and duration of the swallowing sound for liquid or yogurt.
   Conclusions: We concluded that digital cervical auscultation was able to provide objective information about the swallowing process that could contribute to methodological standardization in children.
C1 [Almeida, Sheila T.; Parente, Maria Alice M. P.] Univ Fed Rio Grande do Sul, Serv Pediat, Hosp Clin Porto Alegre, Speech & Language Pathol Unit, BR-90035903 Porto Alegre, RS, Brazil.
   [Almeida, Sheila T.; Parente, Maria Alice M. P.] Univ Fed Rio Grande do Sul, Hosp Clin Porto Alegre, Post Grad Course Med Sci, BR-90035903 Porto Alegre, RS, Brazil.
   [Ferlin, Elton L.] Univ Fed Rio Grande do Sul, Hosp Clin Porto Alegre, Div Biomed Engn, BR-90035903 Porto Alegre, RS, Brazil.
   [Goldani, Helena A. S.] Univ Fed Rio Grande do Sul, Hosp Clin Porto Alegre, Pediat Gastroenterol Unit, BR-90035903 Porto Alegre, RS, Brazil.
RP Almeida, ST (reprint author), Univ Fed Rio Grande do Sul, Serv Pediat, Hosp Clin Porto Alegre, Speech & Language Pathol Unit, Rue Ramiro Barcelos 2350, BR-90035903 Porto Alegre, RS, Brazil.
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NR 25
TC 0
Z9 1
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD APR
PY 2008
VL 117
IS 4
BP 253
EP 258
PG 6
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 288JU
UT WOS:000254983500003
PM 18478833
ER

PT J
AU Merati, AL
   Keppel, K
   Braun, NM
   Blumin, JH
   Kerschner, JE
AF Merati, Albert L.
   Keppel, Kristina
   Braun, Nicole M.
   Blumin, Joel H.
   Kerschner, Joseph E.
TI Pediatric voice-related quality of life: Findings in healthy children
   and in common laryngeal disorders
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT 87th Annual Meeting of the American-Broncho-Esophagological-Association
CY APR 26-27, 2007
CL San Diego, CA
SP Amer Broncho Esophagol Assoc
DE outcome; pediatric voice; quality of life; voice
ID OUTCOME SURVEY; VOCAL QUALITY; VALIDATION; RECONSTRUCTION; PREVALENCE;
   INSTRUMENT; DYSPHONIA
AB Objectives: Although several instruments have been validated to assess voice quality, the incidence and degree of impairment in normal, healthy children has not been widely reported. It is hypothesized that healthy children outside a medical setting do not demonstrate impairment as measured by the Pediatric Voice-Related Quality of Life (PVRQOL) instrument; in contrast, patients with vocal fold paralysis (VFP), vocal nodules (VNs), and paradoxical vocal fold dysfunction (PVFD) have significant impairment as compared to control populations.
   Methods: The PVRQOL was measured prospectively in children with VFP, VNs, and PVFD. The findings were compared to findings in 100 children surveyed at the 2006 Wisconsin State Fair.
   Results: Of the 100 surveys of healthy children and their parents, 95 were completed correctly; their mean (+/-SD) PVRQOL score was 96.8 +/- 5.85. The VFP patients (n = 11; mean PVRQOL score, 70.5 +/- 28.6) reported significant impairment (p < .0001, impaired t-test). This was also true of patients with VNs (n = 13; PVRQOL score, 84.8 +/- 9.4; p < .0001) and PVFD (n = 25; PVRQOL score, 86.7 +/- 14.3; p < .0001); statistically significant differences were also noted for the Social-Emotional and Physical-Functional domains for each of the 3 disease states compared to the group of healthy children (p < .001).
   Conclusions: The PVRQOL scores of healthy children reveal essentially no self-reported vocal impairment. In contrast, common disorders such as VNs, VFP, and PVFD demonstrate statistically significant impairment in age-matched children for total PVRQOL, as well as for the Social-Emotional and Physical-Functional domains. This is the first report of normative PVRQOL data in children.
C1 [Merati, Albert L.; Blumin, Joel H.] Med Coll Wisconsin, Div Laryngol & Profess Voice, Dept Otolaryngol & Commun Sci, Milwaukee, WI 53226 USA.
   [Keppel, Kristina; Braun, Nicole M.; Kerschner, Joseph E.] Med Coll Wisconsin, Div Pediat Otolaryngol, Dept Otolaryngol & Commun Sci, Milwaukee, WI 53226 USA.
RP Merati, AL (reprint author), Univ Washington, Dept Otolaryngol Head & Neck Surg, Sch Med, Box 356515,1959 NE Pacific St, Seattle, WA 98195 USA.
CR Boseley ME, 2006, ARCH OTOLARYNGOL, V132, P717, DOI 10.1001/archotol.132.7.717
   Carding PN, 2006, J VOICE, V20, P623, DOI 10.1016/j.jvoice.2005.07.004
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NR 15
TC 18
Z9 20
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD APR
PY 2008
VL 117
IS 4
BP 259
EP 262
PG 4
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 288JU
UT WOS:000254983500004
PM 18478834
ER

PT J
AU Levine, HL
   Sertich, AP
   Hoisington, DR
   Weiss, RL
   Pritikin, J
AF Levine, Howard L.
   Sertich, Anthony P., II
   Hoisington, Douglas R.
   Weiss, Raymond L.
   Pritikin, Jordan
CA PatiENT Registry Study Grp
TI Multicenter registry of balloon catheter sinusotomy outcomes for 1,036
   patients
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE balloon catheter sinusotomy; chronic rhinosinusitis; sinus surgery
ID FOLLOW-UP; POSTOPERATIVE CARE; FRONTAL-SINUS; SURGERY; COMPLICATIONS;
   SAFETY; FEASIBILITY; DILATION; OSTIUM
AB Objectives: This study assesses the safety and effectiveness of balloon catheters used as instruments in sinus surgery, in a "real-world" multicenter registry of 1,036 patients across 27 US otolaryngology practices.
   Methods: Data were collected by standardized chart review with centralized database administration for all consecutive functional endoscopic sinus surgeries that included the use of balloon catheters across the 18-month time period from December 2005 to May 2007.
   Results: Balloon catheters were used in 3,276 peripheral (maxillary, frontal, and sphenoid) sinuses, for an average of 3.2 sinuses per patient. There were no major adverse events related to the use of balloon catheter instruments. The revision rate was 1.3% of sinuses treated with a balloon catheter after an average follow-up of 40.2 weeks. Sinus symptoms were improved in 95.2%, unchanged in 3.8%, and worse in 1.0% of patients. Postoperative sinus infections were significantly less frequent and less severe compared to infections before surgery. The results were consistent across all patient categories, including balloon-only patients and revision patients.
   Conclusions: Use of balloon catheters as instruments in sinus surgery appears to be relatively safe and effective and to improve the patient's quality of life. The results are consistent and generalizable across a wide range of sinusitis patients and physician practices. The complication rates, revision rates, and patient symptom improvement rates all compare favorably with previously reported results of functional endoscopic sinus surgery.
C1 [Levine, Howard L.] Cleveland Nasal & Sinus Sleep Ctr, Cleveland, OH USA.
   [Hoisington, Douglas R.] ENT Clin Iowa, W Des Moines, IA USA.
   [Sertich, Anthony P., II] Adv Sinus Clin San Antonio, San Antonio, TX USA.
   [Weiss, Raymond L.] Sinus Ctr S, Biloxi, MS USA.
   [Pritikin, Jordan] Chicago Nasal & Sinus Ctr, Chicago, IL USA.
RP Levine, HL (reprint author), 5555 Transportat Blvd, Cleveland, OH 44125 USA.
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NR 27
TC 51
Z9 56
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD APR
PY 2008
VL 117
IS 4
BP 263
EP 270
PG 8
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 288JU
UT WOS:000254983500005
PM 18478835
ER

PT J
AU Koch, M
   Iro, H
   Zenk, J
AF Koch, Michael
   Iro, Heinrich
   Zenk, Johannes
TI Role of sialoscopy in the treatment of Stensen's duct strictures
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT 110th Annual Meeting of the
   American-Academy-of-Otolaryngology-Head-and-Neck-Surgery-Foundation
CY SEP 17-20, 2006
CL Toronto, CANADA
SP Amer Acad Otolaryngol Head & Neck Surg Fdn
DE obstruction; salivary gland; sialoscopy; Stensen's duct; stricture;
   treatment
ID CHRONIC-RECURRENT PAROTITIS; SURGICAL-MANAGEMENT; GLAND; DIAGNOSIS;
   STENOSIS; PAROTIDECTOMY; SIALADENITIS; OBSTRUCTION
AB Objectives: The origin of strictures of Stensen's duct often remains unclear, but chronic recurrent parotitis may be one associated disease. Failure of conservative therapy leads to a recommendation of parotidectomy in a high percentage of cases. Nowadays, development of new, minimally invasive methods may lead to a fundamental change in the treatment regimen.
   Methods: We retrospectively evaluated 39 patients who presented with symptomatic strictures of Stensen's duct from 2002 to 2005. Sialoscopy was performed with semirigid endoscopes. Therapy consisted of irrigation and intraductal infusion of cortisone. If possible, interventional sialoscopy was carried out as the first-line procedure. If indicated, operative procedures of the duct were performed.
   Results: After irrigation and intraductal medication, 17.9% of the patients were free of symptoms. Interventional sialoscopy was carried out in 74.4%, with a success rate of 75.9%. Operative duct procedures (extended papillotomy or resection of papilla stricture with duct reinsertion) were carried out in 23% of cases. In 5.1% of the total cases, parotidectomy was unavoidable.
   Conclusions: Sialoscopy-based methods play a central role in gland-preserving treatment of strictures of Stensen's duct. Sialoscopy has proven to be a fast, useful, and relatively safe therapeutic tool with a high success rate. Parotidectomy is the last choice in symptomatic cases.
C1 [Koch, Michael; Iro, Heinrich; Zenk, Johannes] Univ Erlangen Nurnberg, Dept Otorhinolaryngol Head & Neck Surg, D-91054 Erlangen, Germany.
RP Koch, M (reprint author), Univ Erlangen Nurnberg, Dept Otorhinolaryngol Head & Neck Surg, Waldstr 1, D-91054 Erlangen, Germany.
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NR 32
TC 19
Z9 19
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD APR
PY 2008
VL 117
IS 4
BP 271
EP 278
PG 8
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 288JU
UT WOS:000254983500006
PM 18478836
ER

PT J
AU Carnaby-Mann, GD
   Crary, MA
AF Carnaby-Mann, Giselle D.
   Crary, Michael A.
TI Adjunctive neuromuscular electrical stimulation for treatment-refractory
   dysphagia
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT Conference of the American-Association-of-Speech-Language-Pathology
CY NOV 16-18, 2006
CL Miami, FL
SP Amer Assoc Speech Language Pathol
DE case series; dysphagia; swallowing; treatment
ID PHARYNGEAL DYSPHAGIA; THERAPY; VITALSTIM; STROKE
AB Objectives: Neuromuscular electrical stimulation (NMES) has been proposed as an adjunctive modality for the treatment of swallowing disorders. We present data from a prospective case series to define and measure effects of a systematic therapy for chronic pharyngeal dysphagia using adjunctive NMES.
   Methods: Six adult patients with pharyngeal dysphagia received 15 sessions of a standardized protocol of swallowing exercises with adjunctive NMES. The patients completed clinical and instrumental baseline, posttreatment, and 6-month follow-up evaluations. Outcome measures included the proportion of patients who improved in clinical swallowing ability, functional oral intake, and change in body weight; patient perception of swallowing ability; and changes in kinematic aspects of swallowing.
   Results: Significant change was demonstrated for clinical swallowing ability (p < .042), functional oral intake (p < .02), weight gain (p < .026), and patient perception of swallowing ability (p < .043). Hyoid and laryngeal elevation during swallowing demonstrated bolus-specific patterns of change. No patient experienced a treatment-related or swallowing-related complication. Patients (4 of 5) who were followed out to 6 months after treatment maintained functional gains.
   Conclusions: A systematic therapy for chronic pharyngeal dysphagia using adjunctive NMES produced improvement in clinical swallowing ability and functional oral intake without significant weight loss or complications.
C1 [Carnaby-Mann, Giselle D.] Univ Florida, Coll Publ Hlth & Hlth Profess, Dept Behav Sci & Community Hlth, Gainesville, FL USA.
   [Crary, Michael A.] Univ Florida, Coll Publ Hlth & Hlth Profess, Dept Commun Disorders, Gainesville, FL USA.
RP Carnaby-Mann, GD (reprint author), Div Social & Bahav Sci, 101 S Newell Dr,POB 100175, Gainesville, FL 32610 USA.
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NR 21
TC 28
Z9 28
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD APR
PY 2008
VL 117
IS 4
BP 279
EP 287
PG 9
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 288JU
UT WOS:000254983500007
PM 18478837
ER

PT J
AU Sittel, C
   Blum, S
   Streckfuss, A
   Plinkert, PK
AF Sittel, Christian
   Blum, Sebastian
   Streckfuss, Alexandra
   Plinkert, Peter K.
TI Cricotracheal resection in nontracheotomized adults: A prospective case
   series
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT 87th Annual Meeting of the American-Broncho-Esophagological-Association
CY APR 26-27, 2007
CL San Diego, CA
SP Amer Broncho Esophagol Assoc
DE compromised airway; laryngeal stenosis; laryngotracheal reconstruction;
   laryngotracheal stenosis; subglottic stenosis; ventilation side effect
ID PEDIATRIC SUBGLOTTIC STENOSIS; LARYNGOTRACHEAL STENOSIS; THYROTRACHEAL
   ANASTOMOSIS; TRACHEAL RESECTION; SURGICAL-TREATMENT; MITOMYCIN-C;
   RECONSTRUCTION; MANAGEMENT
AB Objectives: Cricotracheal resection is a modem technique of airway reconstruction used in cases of subglottic stenosis. We report a case series of adult, nontracheotomized patients.
   Methods: Fifteen patients with significant subglottic stenosis were identified as presenting with dyspnea and stridor. The stenosis was grade III in 14 cases and grade II in I case, according to the Cotton classification. The causes were manifold, with intubation and tracheostomy being the predominant risk factors. Cricotracheal resection was performed in all cases with preoperative and postoperative videotracheoscopy.
   Results: The mean postoperative intubation time was 41.7 hours (11 to 103 hours), and the mean length of stay in the intensive care unit was 2.6 days (3 to 9 days). Videotracheoscopy for reassessment was performed after 96 days (average). In 13 of the 15 patients the subglottic lumen was returned to a normal diameter. In I case a recurrent stenosis was managed with repeated endoscopic interventions. One patient died on postoperative day 4 because of a pulmonary embolism. Additional complications consisted of 1 axillary venous embolism, 4 cases of ventilator-associated pneumonia, and I case of transient unilateral recurrent nerve palsy that recovered completely.
   Conclusions: Cricotracheal resection is a reliable and versatile technique for the reconstruction of the subglottic airway, almost regardless of the underlying cause. Most complications observed have not been associated directly with the procedure, but reflect the significant comorbidity of the patient population. There seems to be an increased risk for thromboembolic events that may be a consequence of the preoperative immobilization of dyspneic patients.
C1 [Sittel, Christian; Blum, Sebastian; Streckfuss, Alexandra; Plinkert, Peter K.] Univ Heidelberg, Dept Otorhinolaryngol Head & Neck Surg, Heidelberg, Germany.
RP Sittel, C (reprint author), Univ HNO Klin, Neuenheimer Feld 400, D-69120 Heidelberg, Germany.
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NR 29
TC 7
Z9 7
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD APR
PY 2008
VL 117
IS 4
BP 288
EP 294
PG 7
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 288JU
UT WOS:000254983500008
PM 18478838
ER

PT J
AU Talmon, Y
   Gilbey, P
   Fridman, N
   Wishniak, A
   Roguin, N
AF Talmon, Yoav
   Gilbey, Peter
   Fridman, Nancy
   Wishniak, Alice
   Roguin, Nathan
TI Acute myopericarditis complicating acute tonsillitis: Beware the young
   male patient with tonsillitis complaining of chest pain
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE myocarditis; pericarditis; tonsillitis
ID ACUTE NONRHEUMATIC MYOPERICARDITIS; STREPTOCOCCAL TONSILLITIS;
   MYOCARDITIS
AB Objectives: We describe 11 cases of myopericarditis complicating bacterial tonsillitis.
   Methods: We performed a retrospective study of all cases of myopericarditis treated at one hospital during the years 2005 and 2006.
   Results: The patients were all young men. The average latency from the onset of throat pain to the onset of chest pain was 4.6 days. All patients complained of chest pain. The most common electrocardiographic finding was transient ST segment elevations. The levels of cardiac enzymes and troponin were elevated in all cases.
   Conclusions: Otolaryngologists should be aware of this rare entity. Additional studies are indicated to evaluate the exact incidence of myopericarditis associated with acute streptococcal tonsillitis.
C1 [Talmon, Yoav; Gilbey, Peter] Western Galilee Hosp, Dept Otolaryngol Head & Neck Surg, IL-22100 Nahariyya, Israel.
   [Fridman, Nancy; Wishniak, Alice; Roguin, Nathan] Western Galilee Hosp, Dept Cardiol, IL-22100 Nahariyya, Israel.
RP Gilbey, P (reprint author), Western Galilee Hosp, Dept Otolaryngol Head & Neck Surg, POB 21, IL-22100 Nahariyya, Israel.
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NR 8
TC 6
Z9 6
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD APR
PY 2008
VL 117
IS 4
BP 295
EP 297
PG 3
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 288JU
UT WOS:000254983500009
PM 18478839
ER

PT J
AU Andrews, BT
   Smith, RB
   Hoffman, HT
   Funk, GF
AF Andrews, Brian T.
   Smith, Russell B.
   Hoffman, Henry T.
   Funk, Gerry F.
TI Orocutaneous and pharyngocutaneous fistula closure using a
   vacuum-assisted closure system
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE fistula closure; salivary leak; topical negative pressure dressing;
   vacuum-assisted closure
ID ENTEROCUTANEOUS FISTULAS; RADIATION-THERAPY; WOUND CONTROL; MANAGEMENT;
   COMPLICATIONS; LARYNGECTOMY; SURGERY; HEAD
AB Objectives: The vacuum-assisted closure (VAC) system is a topical negative pressure dressing that has been used extensively to manage a multitude of complicated wounds, including enterocutaneous fistula. We hypothesize that the VAC system may also facilitate the closure of orocutaneous and pharyngocutaneous fistulas.
   Methods: A retrospective chart review was performed.
   Results: Three patients were identified. Two patients developed fistulas after undergoing salvage laryngectomy, and 1 patient developed a fistula after having a hemiglossectomy defect reconstructed by a radial forearm free flap. The VAC system was successful in closing the fistula in 2 of the 3 patients. Complete fistula closure took 3 and 11 days in the 2 cases. The 1 failure of fistula closure was due to poor collapsibility of the neck tissue along the fistula tract caused by fibrosis following prior radiotherapy.
   Conclusions: The VAC system is a feasible treatment option for closing head and neck fistulas, especially when collapsible tissue is present at the fistula site.
C1 [Andrews, Brian T.; Smith, Russell B.; Hoffman, Henry T.; Funk, Gerry F.] Univ Iowa, Coll Med, Dept Otolaryngol Head & Neck Surg, Iowa City, IA 52242 USA.
RP Funk, GF (reprint author), Univ Iowa, Coll Med, Dept Otolaryngol Head & Neck Surg, 21200 Pomerantz Pavil,200 Hawkins Dr, Iowa City, IA 52242 USA.
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NR 15
TC 12
Z9 12
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD APR
PY 2008
VL 117
IS 4
BP 298
EP 302
PG 5
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 288JU
UT WOS:000254983500010
PM 18478840
ER

PT J
AU Mihaescu, M
   Murugappan, S
   Gutmark, E
   Donnelly, LE
   Khosla, S
   Kalra, M
AF Mihaescu, Mihal
   Murugappan, Shanmugam
   Gutmark, Ephraim
   Donnelly, Lane E.
   Khosla, Siddarth
   Kalra, Maninder
TI Computational fluid dynamics analysis of upper airway reconstructed from
   magnetic resonance imaging data
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE airway collapsibility; computational fluid dynamics; obstructive sleep
   apnea
ID OBSTRUCTIVE SLEEP-APNEA; PHARYNGEAL SIZE; STEADY FLOW; CHILDREN;
   WAKEFULNESS; COLLAPSE; MODEL
AB Objectives: We performed flow computations on an accurate upper airway model in a patient with obstructive sleep apnea and computed the velocity, static pressure, and wall shear stress distribution in the model.
   Methods: Cartesian coordinates for airway boundaries were determined from cross-sectional magnetic resonance images, and a 3-dimensional computational model of the upper airway was constructed. Flow simulations were then performed within a FLUENT commercial software framework. Four different flow conditions were simulated during inspiration, assuming the steady-state condition. The results were analyzed from the perspectives of velocity, static pressure, and wall shear stress distribution.
   Results: We observed that the highest axial velocity was at the site of minimum cross-sectional area (retropalatal pharynx) resulting in the lowest level of wall static pressure. The highest wall shear stresses were at the same location. The pressure drop was significantly larger for higher flow rates than for lower flow rates.
   Conclusions: Our results indicate that the presence of airway narrowing, through change in the flow characteristics that result in increased flow velocity and reduced static pressure, can itself increase airway collapsibility. Additionally, the effects of wall shear stress on airway walls may be an important factor in the progression over time of the severity of obstructive sleep apnea.
C1 [Kalra, Maninder] Cincinnati Childrens Hosp, Med Ctr, Div Pulm Med, Cincinnati, OH 45229 USA.
   [Donnelly, Lane E.] Cincinnati Childrens Hosp, Med Ctr, Dept Radiol, Cincinnati, OH 45229 USA.
   [Mihaescu, Mihal; Gutmark, Ephraim] Univ Cincinnati, Dept Aerosp Engn & Engn Mech, Cincinnati, OH 45221 USA.
   [Murugappan, Shanmugam; Khosla, Siddarth] Univ Cincinnati, Dept Otolaryngol, Cincinnati, OH 45221 USA.
RP Kalra, M (reprint author), Cincinnati Childrens Hosp, Med Ctr, Div Pulm Med, 3333 Burnet Ave,MLC 2021, Cincinnati, OH 45229 USA.
EM maninder.kalra@gmail.com
RI Mihaescu, Mihai/F-5650-2010
OI Mihaescu, Mihai/0000-0001-7330-6965
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NR 16
TC 18
Z9 19
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD APR
PY 2008
VL 117
IS 4
BP 303
EP 309
PG 7
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 288JU
UT WOS:000254983500011
PM 18478841
ER

PT J
AU Brook, I
   Gober, AE
AF Brook, Itzhak
   Gober, Alan E.
TI Concurrent influenza A and group A beta-hemolytic streptococcal
   pharyngotonsillitis
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE influenza; pharyngotonsillitis; Streptococcus pyogenes
ID INFECTION; DISEASE; MICE
AB Objectives: A concurrent group A beta-hemolytic Streptococcus (GABHS)-influenza virus pharyngotonsillitis (PT) is generally not considered in diagnoses, even though mixed bacterial-viral infections are common in other respiratory tract infections. This report describes our experience in diagnosing a potential mixed GABHS-influenza virus PT in children.
   Methods: Acute and convalescent antistreptolysin O (ASO) and anti-DNase B titers were obtained from 12 children with acute PT and clinical presentation that suggested viral infection, and in whom both rapid influenza A virus and rapid GABHS tests were positive.
   Results: The children did not receive any antimicrobial therapy, and all recovered from their acute PT within 2 to 5 days and were all asymptomatic upon their return visit 3 to 4 weeks later. GABHS was recovered from 2 of the children on their return visit. However, ASO and anti-DNase B titers were not elevated in these individuals. The ASO and anti-DNase B titers determined in the first serum samples were less than the age-adjusted normal values for all of the children. However, these titers rose by at least two-dilution (0.2 logarithm) in the convalescent sera as compared with the acute ones in 4 of the 12 children (33%). One of the 8 children who had no increase in ASO and anti-DNase B titers had an acute GABHS PT 5 months later. One-year follow-up of all of the children showed no anomalies.
   Conclusions: This report is the first to describe a concomitant GABHS and influenza A virus PT, as evident by increased ASO and anti-DNase B titers in a third of the patients who had both of these organisms detected in their upper airways.
C1 [Brook, Itzhak; Gober, Alan E.] Georgetown Univ, Sch Med, Dept Pediat, Washington, DC 20007 USA.
RP Brook, I (reprint author), 4431 Albemarle St NW, Washington, DC 20016 USA.
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   O'Brien KL, 2002, CLIN INFECT DIS, V35, P268, DOI 10.1086/341409
   Okamoto S, 2004, VACCINE, V22, P2887, DOI 10.1016/j.vaccine.2003.12.024
   Okamoto S, 2003, J VIROL, V77, P4104, DOI 10.1128/JVI.77.7.4104-4112.2003
   Pichichero ME, 1999, ARCH PEDIAT ADOL MED, V153, P624
   Stenfors LE, 2000, J LARYNGOL OTOL, V114, P848
   Tsolia MN, 2004, CLIN INFECT DIS, V39, P681, DOI 10.1086/422996
   van Gageldonk-Lafeber AB, 2005, CLIN INFECT DIS, V41, P490
   YLIKOSKI J, 1989, SCAND J INFECT DIS, V21, P169, DOI 10.3109/00365548909039965
NR 12
TC 3
Z9 4
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD APR
PY 2008
VL 117
IS 4
BP 310
EP 312
PG 3
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 288JU
UT WOS:000254983500012
PM 18478842
ER

PT J
AU Lee, KYS
   Andrew, C
   van Hasselt, CA
   Tong, MCF
AF Lee, Kathy Y. S.
   Andrew, Charles
   van Hasselt, Charles Andrew
   Tong, Michael C. F.
TI Tone perception in cantonese-speaking children with hearing aids
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE cantonese-speaking children; hearing aid; hearing impairment; tone
   perception
ID COCHLEAR IMPLANTATION; IMPAIRED CHILDREN; LANGUAGE; PERFORMANCE; MILD
AB Objectives: In this study we investigated the benefit of using hearing aids for Cantonese tone perception among children with various degrees of hearing impairment.
   Methods: Forty-eight children with moderate to profound hearing loss were investigated. They were required to perform a lexical tone perception test with recorded test stimuli presented at 65 dB in soundproof booths. To allow for comparison, the subjects performed the test under 2 conditions: with their hearing aids turned off (unaided condition) and with them turned on (aided condition).
   Results: The mean tone perception scores for the aided condition were higher than those for the unaided condition across all of the subject groups. Paired sample t-tests showed statistically significant improvement in tone perception in the moderate and severe hearing loss groups (p = .02 and p = .03, respectively). The result obtained from the moderately severe hearing loss group was marginally significant (p = .058). The improvement in tone perception in the profound hearing loss group was insignificant (p = .55).
   Conclusions: The use of a hearing aid is beneficial for Cantonese tone perception in children who have moderate to severe hearing impairment. When a hearing loss is greater than 90 dB, ie, in children who are classified as having profound hearing loss, a hearing aid is not effective in aiding Cantonese tone perception.
C1 Chinese Univ Hong Kong, Dept Otorhinolaryngol Head & Neck Surg, Shatin, Hong Kong, Peoples R China.
   Chinese Univ Hong Kong, Inst Human Commun Res, Shatin, Hong Kong, Peoples R China.
RP Lee, KYS (reprint author), Chinese Univ Hong Kong, Dept Otorhinolaryngol Head & Neck Surg, Prince Wales Hosp, Shatin, Hong Kong, Peoples R China.
RI LEE, Kathy/A-7745-2011
CR Bess FH, 1998, EAR HEARING, V19, P339, DOI 10.1097/00003446-199810000-00001
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   LEE KYS, 2003, THESIS CHINESE U HON
   Lee KYS, 2002, INT J PEDIATR OTORHI, V63, P137, DOI 10.1016/S0165-5876(02)00005-8
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   Yue V, 2000, ADV OTO-RHINO-LARYNG, V57, P220
NR 22
TC 3
Z9 4
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD APR
PY 2008
VL 117
IS 4
BP 313
EP 316
PG 4
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 288JU
UT WOS:000254983500013
PM 18478843
ER

PT J
AU Chhetri, DK
   Merati, AL
   Blumin, JH
   Sulica, L
   Damrose, EJ
   Tsai, VW
AF Chhetri, Dinesh K.
   Merati, Albert L.
   Blumin, Joel H.
   Sulica, Lucian
   Damrose, Edward J.
   Tsai, Veling W.
TI Reliability of the perceptual evaluation of adductor spasmodic dysphonia
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT Meeting of the American-Laryngological-Association
CY APR 26-27, 2007
CL San Diego, CA
SP Amer Laryngol Assoc
DE perceptual assessment; spasmodic dysphonia; voice rating scale
ID VOICE QUALITY; TELEPHONE; TREMOR
AB Objectives: Although perceptual assessment by experienced voice clinicians remains the gold standard for the diagnosis and assessment of severity of adductor spasmodic dysphonia (ADSD), the interrater reliability of voice experts for this task has not been assessed. In addition, it is unknown whether telephone-recorded or -transmitted voice samples could be used for this task. The aims of this study were 1) to assess the reliability of perceptual analysis of ADSD severity by voice experts and 2) to compare the results between digitally recorded voice samples and those recorded over the telephone.
   Methods: Five laryngologists randomly selected voice samples from 46 ADSD patients and rated the severity of ADSD on a 5-point rating scale. A set of digital voice recordings and a set of telephone voice recordings made from filtering the digital set via the telephone were rated, and each voice set was rated twice. Measures of intrarater and interrater reliability, as well as a measure of the probability of agreement among the raters, were calculated.
   Results: There was a high level of agreement on ADSD severity, with excellent interrater and intrarater reliability (Cronbach's alpha, .93 to .96). The probabilities of rater agreement on the digitally recorded and telephone-filtered voice samples were similar (chi(2), p = .07). The ratings of digital versus telephone voice samples were highly correlated (Pearson r, 0.99; p < .001).
   Conclusions: These results demonstrate that voice experts are reliably able to judge and agree on the severity of ADSD. Telephone-filtered voices appear to convey adequate ADSD perceptual cues for expert listeners to judge the severity of spasmodic dysphonia.
C1 [Chhetri, Dinesh K.; Tsai, Veling W.] Univ Calif Los Angeles, Sch Med, Los Angeles, CA 90095 USA.
   [Damrose, Edward J.] Stanford Univ, Sch Med, Dept Otolaryngol, Palo Alto, CA 94304 USA.
   [Merati, Albert L.; Blumin, Joel H.] Med Coll Wisconsin, Dept Otolaryngol & Commun Sci, Milwaukee, WI 53226 USA.
   [Sulica, Lucian] Cornell Univ, Weill Med Coll, Dept Otorhinolaryngol, New York, NY USA.
RP Chhetri, DK (reprint author), Univ Calif Los Angeles, Sch Med, 62-132 CHS, Los Angeles, CA 90095 USA.
CR ARONSON AE, 1968, J SPEECH HEAR DISORD, V33, P219
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   Cannizzaro MS, 2005, CLIN LINGUIST PHONET, V19, P649, DOI 10.1080/02699200412331271125
   Chhetri DK, 2006, LARYNGOSCOPE, V116, P635, DOI 10.1097/01.MLG.0000201990.97955.E4
   DEKROM G, 1995, J SPEECH HEAR RES, V38, P794
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NR 9
TC 3
Z9 4
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD MAR
PY 2008
VL 117
IS 3
BP 159
EP 165
PG 7
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 275XE
UT WOS:000254104700001
PM 18444474
ER

PT J
AU Fukushima, K
   Mimaki, N
   Fukuda, S
   Nishizaki, K
AF Fukushima, Kunihiro
   Mimaki, Nobuyoshi
   Fukuda, Shoichiro
   Nishizaki, Kazunori
TI Pilot study of universal newborn hearing screening in Japan:
   District-based screening program in Okayama
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE automated auditory brain stem response; Japan; negative predictive
   value; newborn hearing screening; positive predictive value; prelingual
   deafness
AB Objectives: Newborn hearing screening was started in Okayama Prefecture in 2001 as part of a nationwide pilot study in Japan. Nearly 50,000 infants have been screened to date, and an observational study and more than 2 years of follow-up of this population are described in this report.
   Methods: Between June 2001 and March 2005 (45 months), 47,346 neonates were screened with automated auditory brain stem response systems and followed up for at least 2 years. This total corresponds to 95% of the infants born in the 44 gynecologic institutions in this district.
   Results: After undergoing the screening process twice, 248 infants (0.52%) received referrals; 108 of them had apparent bilaterally affected hearing, and 140 had apparent unilaterally affected hearing. Among the bilateral cases, hearing impairment was diagnosed in 40 infants, for a total prevalence of hearing impairment of 0.08%. In 3 additional infants who received a bilateral pass result and I infant who received a unilateral pass result, hearing impairment that was progressive or of late onset was subsequently diagnosed. The positive and negative predictive values were calculated as 40% and 99.993%, respectively.
   Conclusions: The screening program was carefully designed to work in the Japanese society and to be well managed in Okayama Prefecture.
C1 [Fukushima, Kunihiro; Nishizaki, Kazunori] Okayama Univ, Postgrad Med Sch Dent & Pharmaceut Sci, Dept Otolaryngol Head & Neck Surg, Okayama 7008558, Japan.
   [Mimaki, Nobuyoshi] Kurashiki Med Ctr, Dept Pediat, Okayama, Japan.
   [Fukuda, Shoichiro] Okayama Kanariya Gakuen, Okayama, Japan.
RP Fukushima, K (reprint author), Okayama Univ, Postgrad Med Sch Dent & Pharmaceut Sci, Dept Otolaryngol Head & Neck Surg, 2-5-1 Shikata Cho, Okayama 7008558, Japan.
CR Clemens CJ, 2000, PEDIATRICS, V106, DOI 10.1542/peds.106.1.e7
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   Kennedy C, 2004, ARCH DIS CHILD, V89, pF378, DOI 10.1136/adc.2004.034454
   Kennedy CR, 2006, NEW ENGL J MED, V354, P2131, DOI 10.1056/NEJMoa054915
   Matsubara K., 2004, HEARING IMPAIRMENT I, P121
   MIMAKI N, 2000, ACTA NEONATOL JPN, V36, P598
   Spivak L, 2000, EAR HEARING, V21, P92, DOI 10.1097/00003446-200004000-00004
   Yoshida K, 2001, PEDIATR INT, V43, P189, DOI 10.1046/j.1442-200x.2001.01370.x
NR 9
TC 7
Z9 9
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD MAR
PY 2008
VL 117
IS 3
BP 166
EP 171
PG 6
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 275XE
UT WOS:000254104700002
PM 18444475
ER

PT J
AU Sikora, AG
   Shnayder, Y
   Yee, H
   DeLacure, MD
AF Sikora, Andrew G.
   Shnayder, Yelizaveta
   Yee, Herman
   DeLacure, Mark D.
TI Oropharyngeal Kaposi sarcoma in related persons negative for human
   immunodeficiency virus
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE human herpesvirus 8; immunocompetence; immunodeficiency; Kaposi sarcoma
ID JEWISH POPULATION; HUMAN-HERPESVIRUS-8; EPIDEMIOLOGY; HERPESVIRUS; MEN;
   DISEASES; ISRAEL; RISK
AB Objectives: Kaposi sarcoma (KS) is a vascular tumor that can affect the mucosa of the upper aerodigestive tract. Although KS is the most common malignancy in patients with acquired immunodeficiency syndrome, it is rare in immunocompetent persons. We describe an unusual presentation of KS in 2 related individuals and describe our attempts to determine whether oropharyngeal KS is associated with human herpesvirus 8 (HHV-8).
   Methods: All relevant clinical and surgical information, including information on tumor histopathologic and human immunodeficiency virus (HIV) serologic tests, was abstracted from the patient charts and electronic databases. HHV-8 immunohistochemistry was performed on paraffin-fixed specimens.
   Results: Both patient 1 and patient 2 (the nephew of patient 1) were referred for workup of a tonsillar mass that was pathologically confirmed to be KS. In each case, HIV serologic testing was negative, and a screening immunologic workup, including a quantitative natural killer cell count, a B- and T-lymphocyte count, and immunoglobulin analysis, also yielded findings that were within normal limits. Immunohistochemistry performed on 1 pathological specimen showed positive staining for the presence of HHV-8, the etiologic agent of KS.
   Conclusions: The presence of oropharyngeal KS in 2 related HIV-negative individuals supports a role for genetic factors in susceptibility to KS, a common exposure to an infectious agent such as HHV-8, or both. Whereas most KS cases in industrialized countries are associated with immunodeficiency, clinical and laboratory data do not suggest that either of the patients described in this report are immunodeficient. Their susceptibility to KS may be secondary to a subtle inherited defect in host resistance to HHV-8, or another unknown factor.
C1 [Sikora, Andrew G.; Shnayder, Yelizaveta; DeLacure, Mark D.] NYU, Sch Med, Dept Otolaryngol Head & Neck Surg, New York, NY USA.
   [Yee, Herman] NYU, Sch Med, Dept Pathol, New York, NY USA.
RP Sikora, AG (reprint author), Univ Texas Houston, MD Anderson Canc Ctr, Dept Head & Neck Surg, 1515 Holcombe Blvd, Houston, TX 77030 USA.
CR Antman K, 2000, NEW ENGL J MED, V342, P1027, DOI 10.1056/NEJM200004063421407
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   Foster CB, 2000, BLOOD, V96, P2562
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NR 20
TC 0
Z9 0
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD MAR
PY 2008
VL 117
IS 3
BP 172
EP 176
PG 5
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 275XE
UT WOS:000254104700003
PM 18444476
ER

PT J
AU Dubin, MR
   Tabaee, A
   Scruggs, JT
   Kazim, M
   Close, LG
AF Dubin, Marika R.
   Tabaee, Abtin
   Scruggs, Jennifer T.
   Kazim, Michael
   Close, Lanny Garth
TI Image-guided endoscopic orbital decompression for Graves' orbitopathy
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT Annual Meeting of the American-Rhinologic-Society
CY SEP   16, 2006
CL Toronto, CANADA
SP Amer Rhinol Soc
DE computer-assisted surgery; endoscopic sinus surgery; Graves'
   orbitopathy; image guidance; orbital decompression
ID SINUS SURGERY; OPHTHALMOPATHY; GUIDANCE; DISEASE; WALL; EXPERIENCE;
   REMOVAL; SYSTEM; FAT
AB Objectives: We studied the efficacy and safety of image-guided balanced orbital decompression for Graves' orbitopathy.
   Methods: The data of 24 patients (45 orbits) were reviewed for demographics, ophthalmologic outcomes, and complications in regard to image-guided (18 orbits) versus non-image-guided surgery (27 orbits).
   Results: Overall, all patients had a reduction in proptosis (mean reduction, 6.2 mm in proptosis) as measured by Hertel exophthalmometry. There was improvement in the visual acuity of all 12 orbits with preoperative acuity of 20/40 or worse and either complete resolution (38%) or improvement (62%) in the 16 orbits with optic neuropathy. These measures reached statistical significance. Despite subjective improvement in surgeon confidence, the use of image guidance did not result in a statistically significant difference in postoperative ophthalmologic outcomes. Medical and sinonasal complications were experienced by 11.1% and 18.5% of patients who underwent image-guided and non-image-guided orbital decompression, respectively.
   Conclusions: Image guidance may be a useful adjunct to balanced orbital decompression for Graves' orbitopathy, but it was not associated with a statistically significant improvement in outcomes in this study.
C1 [Dubin, Marika R.; Tabaee, Abtin; Close, Lanny Garth] Columbia Univ, Coll Phys & Surg, New York Presbyterian Hosp, Dept Otolaryngol Head & Neck Surg, New York, NY USA.
   [Scruggs, Jennifer T.; Kazim, Michael] Columbia Univ, Coll Phys & Surg, New York Presbyterian Hosp, Dept Ophthalmol, New York, NY USA.
   [Kazim, Michael] Columbia Univ, Coll Phys & Surg, New York Presbyterian Hosp, Dept Surg, New York, NY USA.
RP Tabaee, A (reprint author), 10 Union Sq E,Suite 4J, New York, NY 10003 USA.
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NR 23
TC 6
Z9 8
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD MAR
PY 2008
VL 117
IS 3
BP 177
EP 185
PG 9
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 275XE
UT WOS:000254104700004
PM 18444477
ER

PT J
AU Oh, YM
   Oh, DH
   Jeong, SH
   Koo, JW
   Kim, JS
AF Oh, Young-Mi
   Oh, Dong-Hoon
   Jeong, Seong-Hae
   Koo, Ja-Won
   Kim, Ji Soo
TI Sequential bilateral hearing loss in multiple sclerosis
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE hearing loss; multiple sclerosis
ID DEAFNESS; PATTERNS; CONDUCTION; LESION
AB Objectives: We describe a case of multiple sclerosis presenting with sequential bilateral hearing loss.
   Methods: A 46-year-old woman underwent a series of audiological and neurologic evaluations for sequential bilateral hearing losses that occurred 6 months apart.
   Results: Initially, the patient suffered from sudden left hearing loss, and magnetic resonance imaging documented an enhancing lesion in the left middle cerebellar peduncle. Six months later, another episode of sudden vertigo, right hearing loss, and right facial palsy developed. Magnetic resonance imaging disclosed a new lesion in the right middle cerebellar peduncle.
   Conclusions: Sequential bilateral hearing loss may be a manifestation of multiple sclerosis. In younger patients with sudden hearing loss, multiple sclerosis should be included in the differential diagnosis.
C1 [Oh, Young-Mi; Oh, Dong-Hoon; Jeong, Seong-Hae; Kim, Ji Soo] Seoul Natl Univ, Bundang Hosp, Coll Med, Dept Neurol, Songnam 463707, Gyeonggi Do, South Korea.
   [Koo, Ja-Won] Seoul Natl Univ, Bundang Hosp, Coll Med, Dept Otolaryngol, Songnam 463707, Gyeonggi Do, South Korea.
RP Kim, JS (reprint author), Seoul Natl Univ, Bundang Hosp, Coll Med, Dept Neurol, 300 Gumi Dong, Songnam 463707, Gyeonggi Do, South Korea.
RI Koo, Ja-Won/J-5376-2012; Kim, Ji-Soo/D-8744-2012
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NR 29
TC 7
Z9 7
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD MAR
PY 2008
VL 117
IS 3
BP 186
EP 191
PG 6
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 275XE
UT WOS:000254104700005
PM 18444478
ER

PT J
AU Yuan, YL
   Zhou, XH
   Song, J
   Qiu, XP
   Li, J
   Ye, LF
   Meng, XP
   Xia, D
AF Yuan, Yulin
   Zhou, Xuhong
   Song, Jian
   Qiu, Xiaoping
   Li, Jun
   Ye, Linfeng
   Meng, Xiaoping
   Xia, Dong
TI Expression and clinical significance of epidermal growth factor receptor
   and type 1 insulin-like growth factor receptor in nasopharyngeal
   carcinoma
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE epidermal growth factor receptor; immunohistochemistry; nasopharyngeal
   carcinoma; real-time quantitative polymerase chain reaction; type 1
   insulin-like growth factor receptor; Western blot technique
ID FACTOR-I; EPITHELIAL-CELLS; TYROSINE KINASE; BREAST-CANCER;
   CYCLOOXYGENASE-2; ACTIVATION
AB Objectives: Epidermal growth factor (EGF) and type I insulin-like growth factor (IGF-1) receptors play an important role in the growth and apoptosis of nasopharyngeal carcinoma (NPC). They were separately found to be associated with prognosis in patients with NPC. To date, their expression correlation and clinicopathologic significance have never been specifically addressed in NPC.
   Methods: Seventy-five patients with NPC and 21 noncancerous nasopharyngeal epithelial samples were accrued between 1998 and 2006 in a single hospital. The expressions of EGF and IGF-1 receptors were detected by immunohistochemical staining in the 75 NPC samples and the 21 noncancerous samples. Furthermore, the messenger RNA and protein expressions were assessed by real-time quantitative polymerase chain reaction and the Western blot technique, respectively, in NPC cell lines and normal nasopharyngeal epithelial cells.
   Results: The 5-year survival rates, assessed by the Kaplan-Meier method, were 71.4% and 66.6% in the EGF and IGF-1 receptor protein-negative groups, respectively, whereas they were only 28.6% and 33.3% in the receptor protein-positive groups. The levels of these two proteins significantly correlated with each other, and the overexpression rates of EGF and IGF-1 receptors were 65.3% and 56% in nasopharyngeal samples, respectively. Furthermore, both protein expressions were significantly higher in NPC patients with cervical lymph node or distant metastasis than in NPC patients without lymph node or distant metastasis. Recurrence more often appears in cases positive for both proteins than in cases negative for both proteins. The expression levels of the receptor messenger RNA and proteins were higher in several NPC cell lines than in normal nasopharyngeal epithelial cells.
   Conclusions: These findings demonstrate that both receptor proteins may play an important role in the invasion, metastasis, and recurrence of NPC. Both receptors are valuable markers for assessing the prognosis of NPC. Their expression at such high frequencies provides the basis of combined targeted therapy with specific pharmacologic inhibitors to enhance the effects of radiotherapy and chemotherapy.
C1 [Yuan, Yulin; Song, Jian] Wuhan Univ, Sch Med, Fac Anat & Embryol, Dept Anat, Wuhan 430071, Peoples R China.
   [Meng, Xiaoping] Wuhan Univ, Sch Med, Dept Forens Med, Wuhan 430072, Peoples R China.
   [Xia, Dong] Wuhan Univ, Sch Med, Dept Pathol, Wuhan 430072, Peoples R China.
   [Zhou, Xuhong; Li, Jun; Ye, Linfeng] Wuhan Univ, Zhongnan Hosp, Dept Otolaryngol Head & Neck Surg, Wuhan, Peoples R China.
   [Song, Jian] Wuhan Univ, Med Res Ctr, Key Lab Biostruct, Wuhan 430072, Peoples R China.
   [Qiu, Xiaoping] Wuhan Univ, Med Inst Virus Res, Wuhan 430072, Peoples R China.
RP Song, J (reprint author), Wuhan Univ, Sch Med, Fac Anat & Embryol, Dept Anat, 135 Donghu Rd, Wuhan 430071, Peoples R China.
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NR 21
TC 16
Z9 16
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD MAR
PY 2008
VL 117
IS 3
BP 192
EP 200
PG 9
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 275XE
UT WOS:000254104700006
PM 18444479
ER

PT J
AU Chu, PY
   Li, WY
   Chang, SY
AF Chu, Pen-Yuan
   Li, Wing-Yin
   Chang, Shyue-Yih
TI Clinical and pathologic predictors of survival in patients with squamous
   cell carcinoma of the hypopharynx after surgical treatment
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT 3rd World Congress of the
   International-Federation-of-Head-and-Neck-Oncologic-Societies
CY JUN 27-JUL 01, 2006
CL Prague, CZECH REPUBLIC
SP Int Federat Head & Neck Oncol Soc
DE head and neck cancer; hypopharynx; prognostic factor; squamous cell
   carcinoma; surgical treatment
ID EXTRACAPSULAR SPREAD; POSITIVE MARGINS; ORAL CAVITY; CANCER; NECK; HEAD;
   INVASION; METASTASIS; RESECTION; TUMORS
AB Objectives: Hypopharyngeal squamous cell carcinoma (HPSCC) usually presents at an advanced stage. Although chemoradiotherapy has become more popular in treating HPSCC in recent years, surgery with postoperative adjuvant therapy still plays an important role. The purpose of this study was to identify the clinicopathologic factors that predict survival in patients with HPSCC who underwent surgical treatment.
   Methods: Between 1986 and 1995, 94 previously untreated HPSCC patients who underwent surgery with or without postoperative radiotherapy were enrolled. The surgical specimens were reexamined by a single pathologist. The clinicopathologic parameters and prognostic data were analyzed.
   Results: With a median follow-up of 50 months, the 5-year overall survival (OS), disease-specific survival (DSS), and relapse-free survival (RFS) were 47%, 60%, and 58%, respectively. Thirty-seven patients (39%) had tumor recurrence. The level of lymph node metastasis was an independent factor in OS, DSS, and RFS. Neck biopsy before surgery, tumor involvement of more than 1 subsite, and extracapsular spread were independent factors in DSS, as was lymphovascular permeation in RFS.
   Conclusions: The level of cervical lymph node metastasis is the only independent prognostic factor in OS, DSS, and RFS. The addition of postoperative chemoradiotherapy may benefit high-risk cases.
C1 [Chu, Pen-Yuan; Chang, Shyue-Yih] Taipei Vet Gen Hosp, Dept Otolaryngol, Taipei 112, Taiwan.
   [Chu, Pen-Yuan; Chang, Shyue-Yih] Taipei Vet Gen Hosp, Dept Pathol, Taipei 112, Taiwan.
   [Li, Wing-Yin] Natl Yang Ming Univ, Dept Pathol, Taipei 112, Taiwan.
   [Chu, Pen-Yuan; Chang, Shyue-Yih] Natl Yang Ming Univ, Dept Otolaryngol, Taipei 112, Taiwan.
RP Chu, PY (reprint author), Taipei Vet Gen Hosp, Dept Otolaryngol, 201 Sec 2,Shih Pai Rd, Taipei 112, Taiwan.
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NR 25
TC 4
Z9 8
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD MAR
PY 2008
VL 117
IS 3
BP 201
EP 206
PG 6
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 275XE
UT WOS:000254104700007
PM 18444480
ER

PT J
AU Shine, NP
   Rodrigues, S
   Miller, S
   Packer, P
AF Shine, Neville P.
   Rodrigues, Stephen
   Miller, Stuart
   Packer, Peter
TI Bilateral stapedectomy: Association between first- and second-ear
   surgical findings and their effects on the second-ear outcome
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE otosclerosis; stapedectomy
ID OBLITERATIVE OTOSCLEROSIS; EAR; STAPEDOTOMY; BENEFIT; SURGERY
AB Objectives: We assessed the association between first-ear and second-ear surgical findings in patients undergoing second-ear stapedectomy for bilateral otosclerosis and the impact of such findings on the audiometric outcome of the second ear.
   Methods: A retrospective chart review of all stapedectomy patients who underwent stapes surgery by one of two surgeons in a single tertiary referral institution from 1962 to 2001 was performed, and those patients who underwent bilateral stapedectomy were identified. Patient demographic data, surgical findings, procedure performed, and preoperative and postoperative audiometric data were recorded.
   Results: A total of 459 patients (918 ears) underwent bilateral stapedectomy for bilateral otosclerosis during the study period, of whom 426 had complete data for analysis. The finding of a white or obliterated footplate in the second ear was significantly higher if the first ear had this disease manifestation (p < .001, chi(2) test). The association between a second drill-out's being performed and a drill-out in the first operation was significant (p < .001, chi(2) test). Statistical analysis identified that those who underwent a drill-out procedure had a 2.9-fold increase in unsuccessful outcome in comparison to those who did not have a drill-out (odds ratio, 2.89; 95% confidence interval, 1.41 to 5.89). Facial nerve anomalies were infrequently encountered, affecting only 23 patients, of whom 3 had bilateral abnormalities. The finding of an overhanging or dehiscent facial nerve in the second ear was significantly more likely if such an abnormality was identified during the first procedure (23% versus 2.5%; p = .005, Fisher's exact test).
   Conclusions: Second-ear hearing results are poorer in those who require a drill-out of this ear, and this is more likely to be required if a drill-out was required in the first ear, regardless of a successful outcome of the first procedure. Patients should be aware of the reduced likelihood of success in these cases and be counseled regarding risks and benefits of second-ear surgery based, in part, on the findings from the first ear. This study confirms that bilateral advanced footplate obliteration and overhanging or dehiscent facial nerves may be anticipated in patients found to have these abnormalities during first-ear stapedectomy.
C1 [Shine, Neville P.; Rodrigues, Stephen; Miller, Stuart; Packer, Peter] Royal Perth Hosp, Dept Otolaryngol Head & Neck Surg, Perth, WA, Australia.
RP Shine, NP (reprint author), 3 Willows, Dublin 4, Ireland.
CR AMEDEE RG, 1987, LARYNGOSCOPE, V97, P922
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NR 12
TC 2
Z9 3
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD MAR
PY 2008
VL 117
IS 3
BP 207
EP 211
PG 5
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 275XE
UT WOS:000254104700008
PM 18444481
ER

PT J
AU Manrique, M
   Cervera-Paz, FJ
   Insausti, AM
   Nevison, B
AF Manrique, Manuel
   Cervera-Paz, Francisco Javier
   Insausti, Ana M.
   Nevison, Barry
TI Effects of cochlear nuclei electrical stimulation with surface brain
   stem implants in nonhuman primates
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE audition; neuroscience; retrocochlear hearing loss; stereology
ID NEURAL DAMAGE
AB Objectives: We undertook morphological evaluation of the cochlear nucleus complex (CNC) after implantation of a surface auditory brain stem implant (ABI).
   Methods: We used 14 nonhuman primates (Macaca fascicularis). They underwent translabyrinthine bilateral auditory deafferentation and simultaneous unilateral implantation of an ABI. In 6 cases the ABI was not activated, whereas it was activated in 8 cases. The ABI array consisted of 3 platinum disc electrodes mounted on a silicone pad with the back side covered with polyethylene terephthalate mesh, connected via a cable to an external stimulator in animals undergoing electrical stimulations.
   Results: All animals tolerated the procedures well. In both groups of animals, neuropathologic lesions or changes attributed to surgical trauma were found. The biotolerance of neural tissue to the materials used was adequate. The stimulation times ranged from 0 to 732 hours. Neuropathologic examination and stereological assessment revealed that the animals showed no signs of significant neural damage after CNC chronic stimulation if this took place within the safety limits. Time of stimulation did not seem to play a significant role in changes.
   Conclusions: Besides surgical trauma, the most important factors responsible for CNC changes are the electrical stimulation parameters.
C1 [Manrique, Manuel; Cervera-Paz, Francisco Javier] Univ Navarra, Clin Univ, Dept Otorhinolaryngol Head & Neck Surg, Pamplona, Spain.
   [Insausti, Ana M.] Univ Castilla La Mancha, Sch Med, Dept Anat, Albacete, Spain.
   [Nevison, Barry] Cochlear Europe Ltd, Weybridge, Surrey, England.
RP Manrique, M (reprint author), Univ Navarra, Clin Univ, Dept Otorrinolaringol, Avda Pio 12 36, Pamplona 31008, Spain.
CR CERVERAPAZ FJ, 2001, THESIS U NAVARRA
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NR 17
TC 2
Z9 2
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD MAR
PY 2008
VL 117
IS 3
BP 212
EP 220
PG 9
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 275XE
UT WOS:000254104700009
PM 18444482
ER

PT J
AU Thibeault, SL
   Duflo, S
AF Thibeault, Susan L.
   Duflo, Suzy
TI Inflammatory cytokine responses to synthetic extracellular matrix
   injection to the vocal fold lamina propria
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE biomaterial; inflammation; tissue engineering; vocal fold
ID HYALURONIC-ACID; IN-VIVO; PHYSIOLOGY; REPAIR
AB Objectives: We determined cytokine profiles for tumor necrosis factor alpha (TNF-alpha), interleukin (IL)-6, IL-1 alpha, and IL-1 beta after injection of a synthetic extracellular matrix into the vocal fold lamina propria.
   Methods: Transcript expression of inflammatory cytokines was measured with real-time polymerase chain reaction on postoperative days 1, 3, 5, 10, and 21 in 25 rabbits that underwent bilateral vocal fold biopsy with Extracel-LG (Carbylan-GSX 5%) immediately injected into the wound in the left vocal fold and saline solution injected into the wound in the right vocal fold. Two unwounded normal rabbit larynges were also harvested for controls.
   Results: Significantly elevated levels of TNF-alpha, IL-1 beta, and IL-6 were measured on day 3 in a comparison between Extracel-LG-injected vocal folds and saline solution-injected control vocal folds and between Extracel-LG-injected vocal folds and normal vocal folds. All cytokine levels returned to baseline by day 21.
   Conclusions: A mild short-term inflammatory response was measured early after injection of a synthetic extracellular matrix into the vocal fold lamina propria.
C1 [Thibeault, Susan L.] Univ Wisconsin, Sch Med Publ Hlth, Dept Surg, Div Otolaryngol Head & Neck Surg, Madison, WI 53792 USA.
   [Duflo, Suzy] Hop Enfants La Timone, Fed Otorhinolaryngol Head & Neck Surg, Marseille, France.
RP Thibeault, SL (reprint author), Univ Wisconsin, Sch Med Publ Hlth, Dept Surg, Div Otolaryngol Head & Neck Surg, K4-709,600 Highland Ave, Madison, WI 53792 USA.
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   Csoka AB, 2001, MATRIX BIOL, V20, P499, DOI 10.1016/S0945-053X(01)00172-X
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NR 12
TC 19
Z9 19
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD MAR
PY 2008
VL 117
IS 3
BP 221
EP 226
PG 6
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 275XE
UT WOS:000254104700010
PM 18444483
ER

PT J
AU Lim, XH
   Bless, DM
   Munoz-Del-Rio, A
   Welham, NV
AF Lim, Xinhong
   Bless, Diane M.
   Munoz-Del-Rio, Alejandro
   Welham, Nathan V.
TI Changes in cytokine signaling and extracellular matrix production
   induced by inflammatory factors in cultured vocal fold fibroblasts
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE cytokine; extracellular matrix; inflammation; inflammatory factor;
   regeneration; scarless wound healing; vocal fold fibroblast; vocal fold
   scar
ID NECROSIS-FACTOR-ALPHA; NF-KAPPA-B; COLLAGEN GENE-EXPRESSION;
   GROWTH-FACTOR; HYALURONAN SYNTHESIS; SCAR FORMATION; DERMAL FIBROBLASTS;
   SKIN FIBROBLASTS; LUNG FIBROBLASTS; ORAL MUCOSAL
AB Objectives: Modulating cytokine signaling in vocal fold fibroblasts after injury may influence extracellular matrix (ECM) production and eventual fibrotic outcome. To evaluate previously established in vivo cytokine and ECM gene expression hypotheses, we examined in vitro vocal fold fibroblast responses to exogenous inflammatory factor stimulation.
   Methods: Rat vocal fold fibroblast lines derived from explants were separately treated with interleukin-1 beta (IL-1 beta), interferon gamma (IFN-gamma), tumor necrosis factor alpha (TNF-alpha), transforming growth factor beta subtype 1 (TGF-beta 1), or prostaglandin E2 (PGE2). We examined the in vitro messenger RNA expression profiles of IL-1 beta, IFN-gamma, TNF-alpha, TGF-beta 1, and cyclooxygenase 2 (COX-2), as well as those of hyaluronic acid synthase (HAS) 1, HAS-2, procollagen subtype 1, and procollagen subtype 3, at 1, 4, 8, 16, 24, and 72 hours after treatment, and compared them to those of untreated fibroblasts and in vivo data, using real-time reverse transcription-polymerase chain reaction.
   Results: IL-1 beta and TNF-alpha induced each other and synergistically increased HAS-1 and HAS-2 expression. PGE2 also up-regulated HAS-1 and HAS-2 expression. IFN-gamma, IL-1 beta, TNF-alpha, and TGF-beta 1 up-regulated, HAS expression alongside either transient up-regulation of, or no change in, procollagen 1 and 3 expression. Most treatments appeared to suppress procollagen expression, possibly through HAS up-regulation. All inflammatory factors attenuated TGF-beta 1 expression.
   Conclusions: These results confirm several in vivo trends, identify potential cytokine pathways and therapeutic candidates, and suggest the utility of this in vitro setup for future studies.
C1 [Lim, Xinhong; Bless, Diane M.; Munoz-Del-Rio, Alejandro; Welham, Nathan V.] Univ Wisconsin, Sch Med & Publ Hlth, Dept Surg, Div Otolaryngol Head & Neck Surg, Madison, WI USA.
RP Welham, NV (reprint author), K4-723 CSC,600 Highland Ave, Madison, WI 53792 USA.
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NR 46
TC 4
Z9 5
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD MAR
PY 2008
VL 117
IS 3
BP 227
EP 238
PG 12
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 275XE
UT WOS:000254104700011
PM 18444484
ER

PT J
AU Lee, KH
   Rutter, MJ
AF Lee, Kenneth H.
   Rutter, Michael J.
TI Role of balloon dilation in the management of adult idiopathic
   subglottic stenosis
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT 87th Annual Meeting of the American-Broncho-Esophagological-Association
CY APR 26-27, 2007
CL San Diego, CA
SP Amer Broncho Esophagol Assoc
DE balloon dilation; idiopathic subglottic stenosis
ID LARYNGOTRACHEAL STENOSIS; DILATATION; EXPERIENCE; RESECTION; DISEASE
AB Objectives: We evaluated the efficacy of balloon dilation for adjunctive and symptomatic management of isolated idiopathic subglottic stenosis in adults.
   Methods: Adults with airway obstruction symptoms classified as idiopathic subglottic stenosis based on history and findings of a single discrete stenotic area on microlaryngoscopy and bronchoscopy were included in this series. Patients who met these criteria underwent dilation with a 10- to 14-mm balloon in a single procedure or in 2 consecutive dilations within 7 days. The patients were followed for up to 30 months after dilation.
   Results: Six patients met the criteria. One of the 6 had prior laser treatments and a cricotracheal resection. One patient had a previous sear band lysis procedure. The remaining 4 patients had no prior procedures. The airway sizes prior to dilation ranged from a 2.5 endotracheal tube to a 5.0 endotracheal tube. In all cases the airway was dilated to 2.0 to 3.5 endotracheal tube sizes larger than the initial size. To date, 4 patients have been followed for 10 to 30 months without symptoms of recurrent airway stenosis. One patient was symptom-free for 22 months, then presented with progressive airway difficulty following an upper respiratory tract infection, and has undergone a repeat dilation. No patients had adverse effects or complications from the procedure.
   Conclusions: Balloon dilation of idiopathic subglottic stenosis in adults is a relatively safe and effective method to manage this disease entity for cases of isolated and discrete lesions. Patients who underwent a single procedure have remained symptom-free for up to 30 months after balloon dilation.
C1 [Lee, Kenneth H.; Rutter, Michael J.] Cincinnati Childrens Hosp, Med Ctr, Div Pediat Otolaryngol Head & Neck Surg, Cincinnati, OH USA.
   [Rutter, Michael J.] Univ Cincinnati, Coll Med, Dept Otolaryngol Head & Neck Surg, Cincinnati, OH USA.
RP Rutter, MJ (reprint author), Cincinnati Childrens Hosp, Med Ctr, Dept Pediat Otolaryngol, 3333 Burnet Ave,MLC 2018, Cincinnati, OH 45229 USA.
CR Ashiku SK, 2004, J THORAC CARDIOV SUR, V127, P99, DOI 10.1016/j.jtcvs.2002.11.001
   Benjamin B, 1997, ANN OTO RHINOL LARYN, V106, P770
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NR 15
TC 16
Z9 16
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD FEB
PY 2008
VL 117
IS 2
BP 81
EP 84
PG 4
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 264XQ
UT WOS:000253324100001
PM 18357827
ER

PT J
AU Smith, ME
   Roy, N
   Stoddard, K
   Barton, M
AF Smith, Marshall E.
   Roy, Nelson
   Stoddard, Kelly
   Barton, Michael
TI How does cricotracheal resection affect the female voice?
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT 87th Annual Meeting of the American-Broncho-Esophagological-Association
CY APR 26-27, 2007
CL San Diego, CA
SP Amer Broncho Esophagol Assoc
DE cricothyroid muscle; cricotracheal resection; laryngotracheal stenosis;
   voice
ID IDIOPATHIC LARYNGOTRACHEAL STENOSIS; SUBGLOTTIC STENOSIS; PRIMARY
   ANASTOMOSIS; CHILDREN; RECONSTRUCTION; EXPERIENCE; MANAGEMENT; AIRWAY
AB Objectives: We measured the effects of cricotracheal resection on the adult female voice.
   Methods: Voice recordings of 14 women (mean age, 53 years; range, 35 to 69 years) who underwent cricotracheal resection for chronic airway obstruction associated with idiopathic laryngotracheal stenosis were acquired before and after surgery. The recordings were analyzed with voice analysis software. The measures included the mean fundamental frequency of a sustained vowel at a comfortable pitch and loudness (F0), the mean F0 of connected speech (ie, speaking F0), the pitch range (F0 range), and the maximum phonation time. Self-assessment measures of the Voice Handicap Index were taken.
   Results: The mean speaking F0 lowered significantly, by 21 Hz, from 186 Hz to 165 Hz (p =.04). In 7 patients, the speaking F0 was below 160 Hz after the operation. The mean sustained vowel frequency also dropped by 32 Hz (p =.03). The F0 range was reduced by an average of 5.9 semitones, from 21.5 to 15.6 (p =.05). The maximum phonation time did not change significantly. The postoperative mean Voice Handicap Index score was 21.9.
   Conclusions: Cricotracheal resection can significantly impact the adult female voice. It often lowers the pitch of the speaking voice into the male range and reduces the pitch range of the voice. The change in voice that potentially accompanies this procedure should be discussed with patients in preoperative counseling.
C1 [Smith, Marshall E.] Univ Utah, Sch Med, Div Otolaryngol Head & Neck Surg, Salt Lake City, UT 84132 USA.
   [Roy, Nelson; Stoddard, Kelly; Barton, Michael] Univ Utah, Dept Commun Sci & Disorders, Salt Lake City, UT USA.
RP Smith, ME (reprint author), Univ Utah, Sch Med, Div Otolaryngol Head & Neck Surg, 3C-120 SOM,50 N Med Dr, Salt Lake City, UT 84132 USA.
CR Ashiku SK, 2004, J THORAC CARDIOV SUR, V127, P99, DOI 10.1016/j.jtcvs.2002.11.001
   Dedo HH, 2001, ANN OTO RHINOL LARYN, V110, P305
   Giudice M, 2003, EUR ARCH OTO-RHINO-L, V260, P235, DOI 10.1007/s00405-002-0554-y
   Grillo HC, 2003, ANN OTO RHINOL LARYN, V112, P798
   GRILLO HC, 1982, ANN THORAC SURG, V33, P3
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   Herrington HC, 2006, LARYNGOSCOPE, V116, P1553, DOI 10.1097/01.mlg.0000228006.21941.12
   Khosla S, 2007, ANN OTO RHINOL LARYN, V116, P217
   Krival K, 2007, INT J PEDIATR OTORHI, V71, P1261, DOI 10.1016/j.ijporl.2007.04.018
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   Rutter MJ, 2001, ANN OTO RHINOL LARYN, V110, P210
   Stern Y, 1997, ANN OTO RHINOL LARYN, V106, P891
   Triglia JM, 2001, INT J PEDIATR OTORHI, V58, P17, DOI 10.1016/S0165-5876(00)00452-3
   Valdez TA, 2002, ANN OTO RHINOL LARYN, V111, P690
   White DR, 2005, ARCH OTOLARYNGOL, V131, P896, DOI 10.1001/archotol.131.10.896
   Wolf M, 2001, LARYNGOSCOPE, V111, P622, DOI 10.1097/00005537-200104000-00012
NR 19
TC 9
Z9 9
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD FEB
PY 2008
VL 117
IS 2
BP 85
EP 89
PG 5
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 264XQ
UT WOS:000253324100002
PM 18357828
ER

PT J
AU Laflen, JB
   Lazarus, CL
   Amin, MR
AF Laflen, J. Brandon
   Lazarus, Cathy L.
   Amin, Milan R.
TI Pitch deviation analysis of pathological voice in connected speech
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT 87th Annual Meeting of the American-Broncho-Esophagological-Association
CY APR 26-27, 2007
CL San Diego, CA
SP Amer Broncho Esophagol Assoc
DE jitter; perturbation analysis; pitch; speech; voice
ID SUSTAINED VOWELS; DYSPHONIA; RELIABILITY; SEVERITY; JITTER; MODEL
AB Objectives: This study compares normal and pathologic voices using a novel voice analysis algorithm that examines pitch deviation during connected speech. The study evaluates the clinical potential of the algorithm as a mechanism to distinguish between normal and pathologic voices using connected speech.
   Methods: Adult vocalizations from normal subjects and patients with known benign free-edge vocal fold lesions were analyzed. Recordings had been previously obtained in quiet under controlled conditions. Two phrases and sustained /a/ were recorded per subject. The subject populations consisted of 10 normal and 31 abnormal subjects. The voice analysis algorithm generated 2-dimensional patterns that represent pitch deviation in time and under variable window widths. Measures were collected from these patterns for window widths between 10 and 250 ms. For comparison, jitter and shimmer measures were collected from sustained /a/ by means of the Computerized Speech Lab (CSL). A t-test and tests of sensitivity and specificity assessed discrimination between normal and abnormal populations.
   Results: More than 58% of the measures collected from connected speech outperformed the CSL jitter and shimmer measures in population discrimination. Twenty-five percent of the experimental measures (including /a/) indicated significantly different populations (p <.01%).
   Conclusions: The results demonstrate that the algorithm distinguishes between normal and abnormal populations by use of samples of connected speech.
C1 [Laflen, J. Brandon; Lazarus, Cathy L.; Amin, Milan R.] NYU, Sch Med, Dept Otolaryngol, New York, NY USA.
   [Laflen, J. Brandon] NYU, Sch Med, Dept Physiol & Neurosci, New York, NY USA.
   [Laflen, J. Brandon] NYU, Courant Inst Math Sci, Dept Math, New York, NY USA.
   [Lazarus, Cathy L.; Amin, Milan R.] NYU, Voice Ctr, New York, NY USA.
RP Laflen, JB (reprint author), 550 First Ave,NBV 5 E 5, New York, NY 10016 USA.
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NR 26
TC 8
Z9 8
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD FEB
PY 2008
VL 117
IS 2
BP 90
EP 97
PG 8
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 264XQ
UT WOS:000253324100003
PM 18357829
ER

PT J
AU Jatana, KR
   Jacob, A
   Slone, W
   Ray-Chaudhury, A
   Welling, B
AF Jatana, Kris R.
   Jacob, Abraham
   Slone, Wayne
   Ray-Chaudhury, Abhik
   Welling, Bradley
TI Spinal myxopapillary ependymoma metastatic to bilateral internal
   auditory canals
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT Meeting of the Combined Sections of the Triological-Society
CY FEB 14-18, 2007
CL Marco Isl, FL
SP Triol Soc
DE cerebellopontine angle metastasis; ependymoma; internal auditory canal
   metastasis; myxopapillary ependymoma; neurofibromatosis type 2
ID CEREBELLOPONTINE ANGLE; TUMORS
AB Objectives: We report a rare case of spinal myxopapillary ependymoma metastatic to both internal auditory canals (IACs) and its implications for diagnosing neurofibromatosis type 2 (NF2).
   Methods: We present a detailed clinical history, magnetic resonance imaging (MRI), intraoperative photographs, and histopathologic findings from a patient with bilateral IAC lesions, and review the diagnostic criteria for NF2.
   Results: An 11-year-old boy with surgically resected spinal myxopapillary ependymoma, treated with total spine irradiation for recurrence, later showed bilaterally enhancing IAC lesions on T1-weighted MRI with contrast. The diagnosis of NF2 with bilateral vestibular schwannomas was entertained. Close examination of T2-weighted MRI, however, demonstrated the masses to be isointense to cerebrospinal fluid. This finding raised the possibility of other, more unusual IAC lesions. The patient underwent sequential suboccipital craniotomies for tissue diagnosis, and both IAC lesions were found to be myxopapillary ependymomas.
   Conclusions: This is the youngest reported patient with metastatic myxopapillary ependymoma. Although vestibular schwannomas account for the majority of contrast-enhancing T1-weighted IAC lesions, other uncommon lesions may present in a similar manner. A T2 fast-spin echo screening MRI would have missed this patient's lesions. Therefore, both T1-weighted MRI with or without contrast and T2-weighted MRI may be necessary to distinguish vestibular schwannoma from other, more unusual IAC lesions.
C1 [Jatana, Kris R.; Jacob, Abraham; Welling, Bradley] Ohio State Univ, Med Ctr, Dept Otolaryngol Head & Neck Surg, Columbus, OH 43210 USA.
   [Slone, Wayne] Ohio State Univ, Dept Radiol, Columbus, OH USA.
   [Ray-Chaudhury, Abhik] Ohio State Univ, Dept Pathol, Columbus, OH USA.
RP Jacob, A (reprint author), Ohio State Univ, Med Ctr, Dept Otolaryngol Head & Neck Surg, Columbus, OH 43210 USA.
CR Baser ME, 2002, NEUROLOGY, V59, P1759
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   Daniels RL, 2000, AM J OTOL, V21, P173, DOI 10.1016/S0196-0709(00)80005-8
   Ferri G G, 1998, Acta Otorhinolaryngol Ital, V18, P269
   Kittel K, 2001, HNO, V49, P298, DOI 10.1007/s001060050749
   Kohan D, 1997, AM J OTOL, V18, P386
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   Mridha AR, 2007, CHILD NERV SYST, V23, P1209, DOI 10.1007/s00381-007-0423-5
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   Ruggieri M, 1999, CHILD NERV SYST, V15, P295, DOI 10.1007/s003810050398
NR 12
TC 8
Z9 8
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD FEB
PY 2008
VL 117
IS 2
BP 98
EP 102
PG 5
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 264XQ
UT WOS:000253324100004
PM 18357830
ER

PT J
AU Karatas, E
   Durucu, C
   Baglam, T
   Bayazit, YA
   Mumbuc, S
   Kanlikama, M
AF Karatas, Erkan
   Durucu, Cengiz
   Baglam, Tekin
   Bayazit, Yidirim A.
   Mumbuc, Semih
   Kanlikama, Muzaffer
TI Outcomes of otologic surgeries with special interest in learning curves
   of residents in a tertiary referral setting
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE middle ear; outcome; resident; staff; surgery
ID EAR SURGERY; TYMPANOPLASTY; MYRINGOPLASTY
AB Objectives: We evaluated outcomes of otologic surgeries with a special interest in learning curves of residents in a tertiary referral setting.
   Methods: A retrospective review of the outcomes of 811 otologic operations was performed. The outcomes of faculty staff (group 1), senior residents (fifth year; group 2), and residents (fourth year) under supervision of the faculty staff (group 3) were assessed and compared. The faculty staff were available for consultation if needed and were ready to intervene at any stage for group 2.
   Results: There were 397 female patients (48.95%) and 414 male patients (51.04%) from 17 to 71 years of age. There was no statistically significant difference between the groups regarding graft take rate or hearing outcome (p >.05).
   Conclusions: The otologic training of residents appears to be successful in Turkey, as the surgical outcomes of residents were comparable to those of faculty staff.
C1 [Karatas, Erkan; Baglam, Tekin; Mumbuc, Semih; Kanlikama, Muzaffer] Gaziantep Univ, Fac Med, Dept Otolaryngol Head & Neck Surg, Gaziantep, Turkey.
   [Durucu, Cengiz] Gaziantep Univ, Fac Med, Dept Radiol, Gaziantep, Turkey.
   [Bayazit, Yidirim A.] Gazi Univ, Fac Med, Dept Otolaryngol Head & Neck Surg, Ankara, Turkey.
RP Karatas, E (reprint author), Gaziantep Univ, Fac Med, Sahinbey Med Ctr, Dept Otolaryngol Head & Neck Surg, TR-27310 Gaziantep, Turkey.
CR Bhat NA, 2000, J OTOLARYNGOL, V29, P229
   Carr ERM, 2006, J LARYNGOL OTOL, V120, P133, DOI 10.1017/S0022215105000150
   Gerber MJ, 2000, LARYNGOSCOPE, V110, P1994, DOI 10.1097/00005537-200012000-00002
   Mills R, 2003, J LARYNGOL OTOL, V117, P159
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   Onal K, 2005, CLIN OTOLARYNGOL, V30, P115, DOI 10.1111/j.1365-2273.2004.00947.x
   SHELTON C, 1990, LARYNGOSCOPE, V100, P679
   Suzuki M, 2004, ACTA OTO-LARYNGOL, V124, P400, DOI 10.1080/00016480410016478
   Tos M., 1993, MANUAL MIDDLE EAR SU, V1, P2
   VARTIAINEN E, 1986, AM J OTOL, V7, P347
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   Vartiainen E, 1998, CLIN OTOLARYNGOL, V23, P177
NR 13
TC 1
Z9 1
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD FEB
PY 2008
VL 117
IS 2
BP 103
EP 105
PG 3
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 264XQ
UT WOS:000253324100005
PM 18357831
ER

PT J
AU Ahmad, SM
   Soliman, AMS
AF Ahmad, Sidrah M.
   Soliman, Ahmed M. S.
TI Airway obstruction: A rare complication of benign vocal fold polyps
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT 87th Annual Meeting of the American-Broncho-Esophagological-Association
CY APR 26-27, 2007
CL San Diego, CA
SP Amer Broncho Esophagol Assoc
DE airway; complication; obstruction; polyp; vocal fold
ID LARYNGEAL POLYP; LESIONS
AB Objectives: Benign laryngeal polyps usually present with hoarseness and dysphonia. There have been a few reported cases, however, of polyps that caused airway obstruction. Herein we present our series of obstructing laryngeal polyps.
   Methods: A retrospective review was performed of all patients with benign laryngeal lesions treated by the senior author (A.M.S.S.) between 1997 and 2006. Patients who presented with airway obstruction were identified. Detailed information was recorded on the demographics, presenting signs and symptoms, and surgical procedures. Preoperative and postoperative laryngoscopies were reviewed.
   Results: Ten patients were identified. There were 7 women and 3 men. The mean age was 49 years (range, 34 to 64 years). All had a history of vocal abuse and smoking, with a mean of 35.2 pack-years (range, 7.5 to 112.5 pack-years). All underwent microlaryngoscopy with excision of the lesions. Jet ventilation or a small endotracheal tube was used to secure the airway. The mean follow-up of 9 patients was 71.2 days (range, 25 to 208 days); 1 patient was lost to follow-up. An excellent airway and improved voice was achieved in all. Forty-four percent (4 of 9) had persistent dysphonia and a decreased mucosal wave after the operation.
   Conclusions: Benign laryngeal polyps may present with airway obstruction and thus should be included in the differential diagnosis of stridor. Endoscopic treatment can result in an excellent airway, but dysphonia may persist in some cases.
C1 [Ahmad, Sidrah M.; Soliman, Ahmed M. S.] Temple Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, Philadelphia, PA 19140 USA.
RP Soliman, AMS (reprint author), Temple Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, 3400 N Broad St,Kresge W 102, Philadelphia, PA 19140 USA.
CR BASTIAN RW, 2005, CUMMINGS OTOLARYNGOL, P2150
   Benninger MS, 2000, LARYNGOSCOPE, V110, P696
   Courey MS, 1996, ANN OTO RHINOL LARYN, V105, P525
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   GILMAN RH, 1982, J LARYNGOL OTOL, V96, P167, DOI 10.1017/S0022215100092379
   JUHLINDANNFELT M, 1987, J LARYNGOL OTOL, V101, P293, DOI 10.1017/S0022215100101665
   Kelley C, 2000, AM J EMERG MED, V18, P839, DOI 10.1053/ajem.2000.16305
   KOUFMAN JA, 1991, LARYNGOSCOPE, V101, P1
   Levy F E, 1993, Ear Nose Throat J, V72, P587
   Remacle M., 1996, Acta Oto-Rhino-Laryngologica Belgica, V50, P253
   Sulica L, 2003, ANN OTO RHINOL LARYN, V112, P827
   Tsunoda A, 2004, AM J EMERG MED, V22, P63, DOI 10.1016/j.ajem.2003.09.020
   Xu Wen, 2004, Lin Chuang Er Bi Yan Hou Ke Za Zhi, V18, P526
   YANAGISAWA E, 1983, ANN OTO RHINOL LARYN, V92, P340
NR 14
TC 0
Z9 0
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD FEB
PY 2008
VL 117
IS 2
BP 106
EP 109
PG 4
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 264XQ
UT WOS:000253324100006
PM 18357832
ER

PT J
AU Johnson, RF
   Rutter, M
   Cotton, R
   Vijayasekeran, S
   White, D
AF Johnson, Romaine F.
   Rutter, Michael
   Cotton, Robin
   Vijayasekeran, Shyan
   White, David
TI Cricotracheal resection in children 2 years of age and younger
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT 87th Annual Meeting of the American-Broncho-Esophagological-Association
CY APR 26-27, 2007
CL San Diego, CA
SP Amer Broncho Esophagol Assoc
DE cricotracheal resection; infant; subglottic stenosis
ID SUBGLOTTIC STENOSIS; LARYNGOTRACHEAL RECONSTRUCTION; ANASTOMOSIS
AB Objectives: We examine the surgical outcomes of cricotracheal resection in children 2 years of age and younger.
   Methods: We performed a retrospective case study involving a single tertiary care children's hospital. All patients who underwent cricotracheal resection from 1993 through January 2006) were included. Patients 2 years old and younger were compared to patients more than 2 years of age (range, 2 to 44 years). The primary outcomes measured were decannulation and complication rates. We used chi(2) analyses for categorical variables to detect differences in proportions, Student's t-tests for continuous data, and logistical regression to explore for confounding. Significance was set at alpha=.05, 2-tailed.
   Results: Fifteen children 2 years of age or younger were identified. Most patients underwent a single-stage operation (n = 12). The overall decannulation rate was 87% (2 failures). Two patients younger than 2 years had postoperative complications, including 1 patient who developed anastomosis dehiscence. When compared to the patients over 2 years of age, patients younger than 2 were more likely to undergo a single-stage procedure (p <.01). Additionally, the cricotracheal resection was more likely to be their first attempt at airway reconstruction (p =.002). Complication and decannulation rates were similar in both groups.
   Conclusions: Cricotracheal resection can be performed safely and effectively in children less than 2 years old.
C1 [Johnson, Romaine F.; Rutter, Michael; Cotton, Robin; Vijayasekeran, Shyan; White, David] Cincinnati Childrens Med Ctr, Dept Pediat Otolaryngol Head & Neck Surg, Cincinnati, OH USA.
RP Johnson, RF (reprint author), Univ Texas SW Med Ctr Dallas, Dept Otolaryngol, 5323 Harry Hines Blvd, Dallas, TX 75390 USA.
CR Alvarez-Neri H, 2005, ANN OTO RHINOL LARYN, V114, P2
   Amorós Juan Moya, 2006, Eur J Cardiothorac Surg, V29, P35, DOI 10.1016/j.ejcts.2005.10.023
   BERHRMAN RE, 2007, PRETERM BIRTH CAUSE, V1, P1
   COTTON RT, 1981, ANN OTO RHINOL LARYN, V90, P516
   Garabedian EN, 2005, ARCH OTOLARYNGOL, V131, P505, DOI 10.1001/archotol.131.6.505
   Gustafson LM, 2001, ANN OTO RHINOL LARYN, V110, P16
   Hartley BEJ, 2000, INT J PEDIATR OTORHI, V54, P133, DOI 10.1016/S0165-5876(00)00360-8
   Hartley BEJ, 2000, CLIN OTOLARYNGOL, V25, P342, DOI 10.1046/j.1365-2273.2000.00399.x
   Jaquet Y, 2005, J THORAC CARDIOV SUR, V130, P726, DOI 10.1016/j.jtcvs.2005.04.020
   Monnier P., 2003, European Archives of Oto-Rhino-Laryngology, V260, P295, DOI 10.1007/s00405-002-0465-y
   Rutter MJ, 2001, ARCH OTOLARYNGOL, V127, P289
   Rutter MJ, 2001, ANN OTO RHINOL LARYN, V110, P210
   Stern Y, 1997, ANN OTO RHINOL LARYN, V106, P891
   Ward RF, 2000, LARYNGOSCOPE, V110, P835, DOI 10.1097/00005537-200005000-00013
   White DR, 2005, ARCH OTOLARYNGOL, V131, P896, DOI 10.1001/archotol.131.10.896
NR 15
TC 9
Z9 9
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD FEB
PY 2008
VL 117
IS 2
BP 110
EP 112
PG 3
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 264XQ
UT WOS:000253324100007
PM 18357833
ER

PT J
AU Raval, TH
   Elliott, CA
AF Raval, Tejas H.
   Elliott, Clark A.
TI Botulinum toxin injection to the salivary glands for the treatment of
   sialorrhea with chronic aspiration
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT 87th Annual Meeting of the American-Broncho-Esophagological-Association
CY APR 26-27, 2007
CL San Diego, CA
SP Amer Broncho Esophagol Assoc
DE aspiration; botulinum toxin; sialorrhea
ID CEREBRAL-PALSY; CHILDREN; MANAGEMENT; LIGATION
AB Objectives: Chronic aspiration of salivary secretions can cause major pulmonary morbidity in neurologically impaired patients. Many treatments are proposed to address these problems, some with significant side effects. Botulinum toxin type A injection into the salivary glands is known to reduce salivary flow without major complications. Few reports exist regarding the use of this treatment in the prevention of recurrent aspiration pneumonia. We studied the effects of this treatment for patients with recurrent aspiration pneumonia.
   Methods: We performed a chart review of 12 patients, ranging in age from 7 months to 37 years, treated with botulinum toxin injections at a single tertiary care institution. A caregiver telephone questionnaire was also administered. The numbers of pulmonary infections and hospitalizations before and after the initiation of treatment were compared.
   Results: Nine of 12 patients reported improvement in the numbers of hospitalizations and pulmonary infections following botulinum toxin injections. Reduction in the use of anticholinergic medication and reduced pulmonary toilet requirements were also noted. There were no complications of treatment.
   Conclusions: Botulinum toxin injection into the salivary glands can be effective in reducing pulmonary morbidity in many neurologically impaired patients. This relatively simple technique offers an alternative to the use of anticholinergic medication and may obviate the need for more invasive surgical treatment in certain patients.
C1 [Raval, Tejas H.; Elliott, Clark A.] Floating Hosp Children, Tufts New England Med Ctr, Dept Otolaryngol Head & Neck Surg, Boston, MA USA.
RP Elliott, CA (reprint author), Tufts Univ New England Med Ctr, 750 Washington St, Boston, MA 02111 USA.
CR Bachrach SJ, 1998, CLIN PEDIATR, V37, P485, DOI 10.1177/000992289803700805
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   Crysdale WS, 2006, INT J PEDIATR OTORHI, V70, P519, DOI 10.1016/j.ijporl.2005.07.021
   Ellies M, 2002, NEUROPEDIATRICS, V33, P327, DOI 10.1055/s-2002-37084
   Gerber ME, 1996, ARCH OTOLARYNGOL, V122, P1368
   Hockstein NG, 2004, AM FAM PHYSICIAN, V69, P2628
   Jongerius PH, 2003, LARYNGOSCOPE, V113, P107, DOI 10.1097/00005537-200301000-00020
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   Tomita T, 2004, J LARYNGOL OTOL, V118, P15
NR 19
TC 4
Z9 4
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD FEB
PY 2008
VL 117
IS 2
BP 118
EP 122
PG 5
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 264XQ
UT WOS:000253324100009
PM 18357835
ER

PT J
AU Couloigner, V
   Grayeli, AB
   Sterkers, O
   Ferrary, E
AF Couloigner, Vincent
   Grayeli, Alexis Bozorg
   Sterkers, Olivier
   Ferrary, Evelyne
TI Composition of the endolymphatic sac luminal fluid in a patient with
   Mondini dysplasia
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE endolymph; inner ear; ion; osmolarity; protein
ID GUINEA-PIG COCHLEA; MEMBRANOUS LABYRINTH; INNER-EAR; DUCT
AB Objectives: We determined the chemical composition of the human endolymphatic sac luminal fluid in a patient with Mondini dysplasia.
   Methods: Four milliliters of endolymphatic sac luminal fluid was sampled in a 41-year-old patient who presented with bilateral Mondini dysplasia and underwent auditory brain stem implantation. Ion and protein concentrations, as well as the osmolarity of the fluid, were analyzed by means of biochemical automated procedures.
   Results: The sodium, potassium, and protein concentrations and the osmolarity of the sample were 87 mmol/L, 24 mmol/L, 33.5 g/L, and 258 mOsm/L, respectively.
   Conclusions: The composition of the endolymphatic sac luminal fluid found in our patient was similar to that determined in guinea pigs under physiological conditions, and very different from the usual composition of the cochleovestibular endolymph. Contamination of the cochleovestibular endolymphatic compartment by this sodium-rich, potassium-poor, and hypo-osmotic fluid might impair cochleovestibular function by altering the chemical composition of the cochleovestibular endolymph.
C1 [Couloigner, Vincent; Grayeli, Alexis Bozorg; Sterkers, Olivier; Ferrary, Evelyne] Univ Paris 07, Fac Xavier Bichat, INSERM, F-75221 Paris 05, France.
   [Couloigner, Vincent] Hop Necker Enfants Malad, Dept Pediat Otolaryngol, Paris, France.
   [Grayeli, Alexis Bozorg; Sterkers, Olivier; Ferrary, Evelyne] Assistance Publ Hop Paris, Beaujon Hosp, Dept Otolaryngol, Paris, France.
RP Couloigner, V (reprint author), Hop Necker Enfants Malad, Serv ORL Pediat, 149 rue de Sevres, F-75015 Paris, France.
CR Buckingham RA, 2001, ANN OTO RHINOL LARYN, V110, P113
   Couloigner V, 1999, ACTA OTO-LARYNGOL, V119, P200
   Couloigner V, 2004, ACTA OTO-LARYNGOL, V124, P449, DOI 10.1080/00016480310000700
   FURUTA H, 1992, ACTA OTO-LARYNGOL, V112, P791, DOI 10.3109/00016489209137476
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NR 19
TC 1
Z9 2
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD FEB
PY 2008
VL 117
IS 2
BP 123
EP 126
PG 4
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 264XQ
UT WOS:000253324100010
PM 18357836
ER

PT J
AU Zhang, L
   Han, DM
   Song, X
   Wang, KJ
   Wang, H
AF Zhang, Luo
   Han, Demin
   Song, Xiaohong
   Wang, Kuiji
   Wang, Hong
TI Effect of oxymetazoline on healthy human nasal ciliary beat frequency
   measured with high-speed digital microscopy and mucociliary transport
   time
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE ciliary beat frequency; microscopy; mucociliary transport time; nasal
   epithelial cell; oxymetazoline
ID INTRACELLULAR CALCIUM; EPITHELIAL-CELLS; IN-VITRO; CLEARANCE;
   DECONGESTANTS; MUCOSA; PHENYLEPHRINE; TACHYPHYLAXIS; CULTURE; NOSE
AB Objectives: We investigated the effects of oxymetazoline hydrochloride on the regulation of healthy human nasal ciliary beat frequency (CBF) and its influence on nasal mucociliary transport time (MTT).
   Methods: Changes in (cultured) human nasal CBF in response to increasing concentrations of oxymetazoline within 20 minutes were quantified by use of high-speed digital microscopy. Moreover, the MTT before and after application of 0.05% oxymetazoline was determined by use of the saccharin test.
   Results: Whereas no statistically significant difference was identified when compared to basal CBF at the concentration of 0.025% or 0.05%, both 0. 10% and 0.20% oxymetazoline induced a significantly lower CBF at the end of the observation period. The decrement induced by 0.20% oxymetazoline appeared earlier. At concentrations ranging from 0.025% to 0.20%, the inhibitory effect was dependent on the concentration of oxymetazoline. In addition, the use of 0.05% oxymetazoline increased the mean (+/- SD) human nasal MTT from 474 +/- 21 seconds to 572 +/- 41 seconds (n = 29).
   Conclusions: The clinical concentration of oxymetazoline, 0.05%, has no obvious inhibitory effect on human nasal CBF in vitro. The increased MTT caused by 0.05% oxymetazoline in vivo is within the normal range.
C1 [Zhang, Luo; Han, Demin; Song, Xiaohong; Wang, Kuiji; Wang, Hong] Affiliated Beijing Tongren Hosp Capital Med Univ, Beijing Inst Otorhinolaryngol, Dept Otolaryngol Head & Neck Surg, Beijing, Peoples R China.
RP Han, DM (reprint author), Affiliated Beijing Tongren Hosp Capital Med Univ, Dept Otolaryngol Head & Neck Surg, Beijing 100730, Peoples R China.
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NR 39
TC 4
Z9 6
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD FEB
PY 2008
VL 117
IS 2
BP 127
EP 133
PG 7
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 264XQ
UT WOS:000253324100011
PM 18357837
ER

PT J
AU Khosla, S
   Murugappan, S
   Lakhamraju, R
   Gutmark, E
AF Khosla, Sid
   Murugappan, Shanmugam
   Lakhamraju, Raghavaraju
   Gutmark, Ephraim
TI Using particle imaging velocimetry to measure anterior-posterior
   velocity gradients in the excised canine larynx model
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT Meeting of the American-Laryngological-Association
CY APR 26-27, 2007
CL San Diego, CA
SP Amer Laryngol Assoc
DE anterior-posterior velocity gradient; particle imaging velocimetry;
   phonation; vocal fold; voice production; vortex
ID DYNAMIC-MECHANICAL MODEL; VOCAL FOLDS; FLOW; PHONATION; JET; TRACT;
   FIELD
AB Objectives: To quantify the anterior-posterior velocity gradient, we studied the velocity flow fields above the vocal folds in both the midcoronal and midsagittal planes. It was also our purpose to use these fields to deduce the mechanisms that cause the anterior-posterior gradient and to determine whether the vortical structures are highly 3-dimensional.
   Methods: Using the particle imaging velocimetry method for 5 excised canine larynges, we obtained phase-averaged velocity fields in the midcoronal and midsagittal planes for 30 phases of phonation. The velocity fields were determined synchronously with the vocal fold motion recorded by high-speed videography.
   Results: The results show that immediately above the folds, there is no significant anterior-posterior velocity gradient. However, as the flow travels downstream, the laryngeal jet tends to narrow in width and skew toward the anterior commissure. Vortices are seen at the anterior and posterior edges of the flow.
   Conclusions: The downstream narrowing in the midsagittal plane is consistent with and is probably due to a phenomenon known as axis switching. Axis switching also involves vortices in the sagittal and coronal planes bending in the axial plane. This results in highly 3-dimensional, complex vortical structures. However, there is remarkable cyclic repeatability of these vortices during a phonation cycle.
C1 [Khosla, Sid; Murugappan, Shanmugam; Gutmark, Ephraim] Univ Cincinnati, Med Ctr, Dept Otolaryngol Head & Neck Surg, Cincinnati, OH 45267 USA.
   [Lakhamraju, Raghavaraju; Gutmark, Ephraim] Univ Cincinnati, Dept Aerosp Engn & Engn Mech, Cincinnati, OH USA.
RP Khosla, S (reprint author), Univ Cincinnati, Med Ctr, Dept Otolaryngol Head & Neck Surg, 231 Albert B Sabin Way,ML 0528, Cincinnati, OH 45267 USA.
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NR 19
TC 18
Z9 18
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD FEB
PY 2008
VL 117
IS 2
BP 134
EP 144
PG 11
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 264XQ
UT WOS:000253324100012
PM 18357838
ER

PT J
AU Welham, NV
   Lim, X
   Tateya, I
   Bless, DM
AF Welham, Nathan V.
   Lim, Xinhong
   Tateya, Ichiro
   Bless, Diane M.
TI Inflammatory factor profiles one hour following vocal fold injury
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT 36th Annual Symposium on Care of the Professional Voice
CY MAY 29-JUN 03, 2007
CL Philadelphia, PA
DE cytokine; extracellular matrix; inflammation; scar; vocal fold; wound
   healing
ID HYALURONAN SYNTHESIS; CYTOKINE REGULATION; LUNG FIBROBLASTS; EXPRESSION;
   CELLS; DEGRADATION; PLATELETS; REPAIR; ALPHA
AB Objectives: Inflammatory factors are key mediators of wound healing processes following injury, and their modulation may improve healing outcomes. The objective of this study was to characterize in vivo inflammatory factor and extracellular matrix (ECM) messenger RNA (mRNA) expression levels 1 hour after vocal fold injury.
   Methods: Five Sprague-Dawley rats were subjected to bilateral vocal fold injury, 5 rats were reserved as uninjured controls, and 1 rat was subjected to unilateral vocal fold injury and reserved for histology. Tissue was harvested 1 hour after injury. Real-time reverse transcription-polymerase chain reaction was performed to examine the mRNA expression profiles of inflammatory factors nuclear factor kappa beta (NF-kappa beta), interferon gamma (IFN-gamma), cyclooxygenase 2 (COX-2), transforming growth factor beta isoform 1 (TGF-beta 1), tumor necrosis factor alpha (TNF-alpha), and interleukin 1 beta (IL-1 beta), as well as ECM genes hyaluronic acid synthase (HAS) 1, HAS-2, procollagen 1, procollagen 3, and elastin, in the injured samples compared with the uninjured controls.
   Results: Injury resulted in subepithelial bleeding throughout the vocal fold. The COX-2, TNF-alpha, IL-1 beta, and HAS-1 mRNA expression levels were significantly up-regulated 1 hour after injury compared with the uninjured controls.
   Conclusions: Inflammatory factor and ECM gene expression changes occur in vocal fold wound sites as early as 1 hour after injury. These results should inform future efforts to attenuate vocal fold scarring via the modulation of inflammatory factors.
C1 [Welham, Nathan V.; Lim, Xinhong; Tateya, Ichiro; Bless, Diane M.] Univ Wisconsin, Sch Med & Publ Hlth, Dept Surg, Div Otolaryngol, Madison, WI USA.
RP Welham, NV (reprint author), K4-723 CSC,600 Highland Ave, Madison, WI 53792 USA.
CR Branski RC, 2007, J VOICE, V21, P651, DOI 10.1016/j.jvoice.2006.06.005
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NR 22
TC 26
Z9 26
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD FEB
PY 2008
VL 117
IS 2
BP 145
EP 152
PG 8
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 264XQ
UT WOS:000253324100013
PM 18357839
ER

PT J
AU Tateya, I
   Tateya, T
   Surles, RL
   Kanehira, K
   Tanurnihardjo, S
   Bless, DM
AF Tateya, Ichiro
   Tateya, Tomoko
   Surles, Rebecca Lynn
   Kanehira, Kazunori
   Tanurnihardjo, Sherry
   Bless, Diane M.
TI Vitamin A deficiency causes metaplasia in vocal fold epithelium: A rat
   study
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT 127th Annual Meeting of the American-Laryngological-Association
CY MAY 19-20, 2006
CL Chicago, IL
SP Amer Laryngol Assoc
DE keratinization; transglutaminase 1; vitamin A; vocal fold
ID KERATINOCYTE TRANSGLUTAMINASE; TRACHEOBRONCHIAL EPITHELIUM; ORAL
   LEUKOPLAKIA; GENE-EXPRESSION; DIFFERENTIATION; CANCER; RISK
AB Objectives: The roles of vitamin A in the vocal fold epithelium are not well documented, although vitamin A has been used as a conservative treatment for laryngeal leukoplakia. The purpose of this study was to analyze the roles of vitamin A in vocal fold epithelial differentiation.
   Methods: Vitamin A-deficient (VAD) rats were generated, and the abnormality of their vocal fold epithelium was examined by hematoxylin and eosin staining and immunohistochemical analysis for keratin 10 and transglutaminase (TGase) 1.
   Results: The VAD experimental rats exhibited orthokeratosis of the vocal fold epithelium. Keratin 10 and TGase 1 were up-regulated in the epithelium of the VAD rats.
   Conclusions: It is suggested that vitamin A suppresses TGase I expression in normal vocal folds to inhibit keratinization, and that the TGase I up-regulation caused by vitamin A deficiency may be related to the formation of metaplasia in the laryngeal epithelium.
C1 [Tateya, Ichiro] Kyoto Katsura Hosp, Dept Otolaryngol, Kyoto, Japan.
   [Tateya, Tomoko] Kyoto Univ, Grad Sch Med, Dept Otolaryngol Head & Neck Surg, Kyoto, Japan.
   [Tateya, Ichiro; Tateya, Tomoko; Bless, Diane M.] Univ Wisconsin, Dept Surg, Div Otolaryngol Head & Neck Surg, Madison, WI USA.
   [Surles, Rebecca Lynn; Tanurnihardjo, Sherry] Univ Wisconsin, Dept Nutr Sci, Madison, WI USA.
   [Kanehira, Kazunori] Univ Wisconsin, Dept Pathol, Madison, WI USA.
RP Tateya, I (reprint author), Kyoto Katsura Hosp, Dept Otolaryngol, Nishikyo Ku, 17 Yamada Hirao-cho, Kyoto 6158256, Japan.
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NR 19
TC 3
Z9 3
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD FEB
PY 2008
VL 117
IS 2
BP 153
EP 158
PG 6
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 264XQ
UT WOS:000253324100014
PM 18357840
ER

PT J
AU Mouadeb, DA
   Rees, CJ
   Belafsky, PC
AF Mouadeb, Debbie A.
   Rees, Catherine J.
   Belafsky, Peter C.
TI Utilization of the LifeStat emergency airway device
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE airway management; airway obstruction; cricothyrotomy
ID PRIMARY-CARE PHYSICIANS; LARYNGEAL MASK AIRWAY; CRICOTHYROTOMY;
   MANAGEMENT; CRICOTHYROIDOTOMY; COMBITUBE; GENERALISTS; INTUBATION;
   ATTITUDES
AB Objectives: Management of the airway in an emergency may be a harrowing experience. The equipment necessary to perform this procedure is often inaccessible. The LifeStat emergency airway is a portable device approved by the US Food and Drug Administration in 1997 for emergency cricothyrotomy. It is small enough to secure to a keychain, thus allowing instantaneous access at all times. We present a retrospective case series to report the experience of clinicians who have used the LifeStat device. Methods: A survey instrument was sent to a convenience sample of health-care professionals who purchased the LifeStat emergency airway. The survey queried device use, user demographics, and the success, ease, complications, and location of use.
   Results: One thousand surveys were distributed, and 100 individuals responded. Fifteen percent (15 of 100) reported use of the device on 17 occasions. The LifeStat was used successfully in all 17 cases. Eighty-two percent (14 of 17) of emergency use was in hospitals. In all cases the device was positioned successfully on the first attempt. No complications were reported.
   Conclusions: The LifeStat device provides a relatively safe and effective means of performing emergency cricothyrotomy. The majority of emergency situations in which the device was deployed occurred in hospital settings.
C1 [Mouadeb, Debbie A.; Rees, Catherine J.; Belafsky, Peter C.] Univ Calif Davis, Med Ctr, Dept Otolaryngol Head & Neck Surg, Sacramento, CA 95817 USA.
RP Belafsky, PC (reprint author), Univ Calif Davis, Med Ctr, Dept Otolaryngol Head & Neck Surg, 2521 Stockton Blvd,Suite 7200, Sacramento, CA 95817 USA.
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NR 20
TC 3
Z9 3
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD JAN
PY 2008
VL 117
IS 1
BP 1
EP 4
PG 4
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 252NS
UT WOS:000252453800001
PM 18254362
ER

PT J
AU Umeno, H
   Chitose, S
   Sato, K
   Nakashima, T
AF Umeno, Hirohito
   Chitose, Shun-ichi
   Sato, Kiminori
   Nakashima, Tadashi
TI Efficacy of additional injection laryngoplasty after framework surgery
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE arytenoid adduction; framework surgery; injection laryngoplasty;
   thyroplasty; voice function
ID VOCAL FOLD PARALYSIS; ARYTENOID ADDUCTION; I THYROPLASTY; MEDIALIZATION
AB Objectives: The purpose of this study was to clarify the efficacy of additional injection laryngoplasty (AIL) after framework surgery (FS), while also trying to identify which patients or procedures were more likely to require AIL to obtain optimal results and to clarify why.
   Methods: Fifty-two patients with unilateral vocal fold paralysis underwent FS (thyroplasty [TP], 23; arytenoid adduction [AA], 18; and AA with TP, 11). The numbers of patients who required AIL were calculated for each type of FS. The voice function after AIL was investigated. Thereafter, the width and the bowing ratios on phonation were measured in patients who underwent AA.
   Results: The patients who underwent AA required AIL more frequently than did patients who underwent TP. Use of AIL provided better voice function for all patients. The width ratio after AA decreased in all cases, but the bowing ratio increased after AA in 44% of cases.
   Conclusions: These results indicate that AIL is an effective treatment for patients who still have a glottal gap after undergoing FS. In particular, patients who had AA frequently required AIL, in comparison to patients who had TP, because of the high frequency of an increased bowing ratio after AA.
C1 [Umeno, Hirohito; Chitose, Shun-ichi; Sato, Kiminori; Nakashima, Tadashi] Kurume Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, Kurume, Fukuoka 8300011, Japan.
RP Umeno, H (reprint author), Kurume Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, 67 Asahi Machi, Kurume, Fukuoka 8300011, Japan.
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NR 12
TC 7
Z9 7
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD JAN
PY 2008
VL 117
IS 1
BP 5
EP 10
PG 6
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 252NS
UT WOS:000252453800002
PM 18254363
ER

PT J
AU Magliulo, G
   Parrotto, D
   Gagliardi, M
AF Magliulo, Giuseppe
   Parrotto, Donato
   Gagliardi, Mario
TI Vestibular evoked myogenic and periocular potentials after vestibular
   schwannoma surgery
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE schwannoma; vestibular evoked myogenic potential; vestibular evoked
   periocular potential; vestibular evoked potential
ID MODIFIED TRANSLABYRINTHINE APPROACH; BONE-CONDUCTED SOUND; GUINEA-PIG;
   ENDOLYMPHATIC HYDROPS; NEURONS; PRESERVATION; RESPONSES; STIMULATION;
   ORIGIN; CLICKS
AB Objectives: We analyzed the behavior of preoperative and postoperative vestibular evoked myogenic potentials (VEMPs) and vestibular evoked periocular potentials (VEPPs) in 3 patients who had vestibular schwannoma and underwent modified translabyrinthine surgery.
   Methods: We compared VEMPs and VEPPs, measured with both air-conducted (AC) and bone-conducted (BC) stimulations. Vestibular evoked potentials were measured both in the immediate postoperative period and some months later.
   Results: At the immediate postoperative examination, VEPPs were preserved in all 3 patients with both AC and BC stimulations. The VEMPs showed stable or improved parameters in 2 of our patients and were absent in the third patient. At the follow-up examination, VEMPs did not show any significant change with respect to the previous evaluation: In contrast, VEPPs were absent in 2 of our patients with AC stimulation and in I patient with BC stimulation.
   Conclusions: Our results seem to indicate a greater stability and reproducibility of VEMPs compared with VEPPs. In 1 patient, who had a schwannoma of the inferior vestibular nerve, the preservation of VEPPs and the absence of VEMPs in the immediate postoperative period confirm that the saccule represents the origin of VEMPs. Furthermore, these results suggest that not only the saccule, but also the utriculus, could be implicated in the origin of VEPPs.
C1 [Magliulo, Giuseppe; Parrotto, Donato; Gagliardi, Mario] Univ Roma La Sapienza, Dept Otorhinolaryngol Audiol & Phoniatr G Ferreri, Rome, Italy.
RP Magliulo, G (reprint author), Via Gregorio 7 N 80, I-00165 Rome, Italy.
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   Tsutsumi T, 2000, AM J OTOL, V21, P712
   YOUNG ED, 1977, ACTA OTO-LARYNGOL, V84, P352, DOI 10.3109/00016487709123977
NR 21
TC 1
Z9 1
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD JAN
PY 2008
VL 117
IS 1
BP 11
EP 14
PG 4
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 252NS
UT WOS:000252453800003
PM 18254364
ER

PT J
AU Cohen, SD
   Matthews, BL
AF Cohen, Samuel D.
   Matthews, Brian L.
TI Large concha bullosa mucopyocele replacing the anterior ethmoid sinuses
   and contiguous with the frontal sinus
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE concha bullosa; middle turbinate; mucocele; mucopyocele; paranasal sinus
ID MUCOCELE
AB Concha bullosa, a pneumatized middle turbinate, is a common anatomic variant found in the paranasal sinuses. When a concha bullosa becomes obstructed, it can form a mucocele and, eventually, a mucopyocele if it becomes secondarily infected. This is a rare phenomenon; only 9 concha bullosa mucopyoceles have been previously reported in the English-language literature. We present the case of a large concha bullosa mucopyocele in a pediatric patient in which the concha bullosa replaced the anterior ethmoid sinuses and was contiguous with the frontal sinus.
C1 [Cohen, Samuel D.; Matthews, Brian L.] Wake Forest Univ, Bowman Gray Sch Med, Dept Otolaryngol Head & Neck Surg, Winston Salem, NC 27157 USA.
RP Matthews, BL (reprint author), Wake Forest Univ, Bowman Gray Sch Med, Dept Otolaryngol Head & Neck Surg, Med Ctr Blvd, Winston Salem, NC 27157 USA.
CR BAHADIR O, 2003, AURIX NASUS LARYNX, V33, P195
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   Zuckerkandl E, 1893, UNTERE SIEBBEINMUSCH, VVols 2
NR 10
TC 8
Z9 8
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD JAN
PY 2008
VL 117
IS 1
BP 15
EP 17
PG 3
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 252NS
UT WOS:000252453800004
PM 18254365
ER

PT J
AU Bhattacharyya, N
   Wasan, A
AF Bhattacharyya, Neil
   Wasan, Ajay
TI Do anxiety and depression confound symptom reporting and diagnostic
   accuracy in chronic rhinosinusitis?
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE anxiety; chronic rhinosinusitis; depression; diagnosis
ID ENDOSCOPIC SINUS SURGERY; OF-THE-LITERATURE; CHRONIC PAIN; PREVALENCE;
   DISORDERS; OUTCOMES; ASSOCIATION
AB Objectives: We sought to determine the impact of psychiatric comorbidity on symptom reporting and diagnostic accuracy in chronic rhinosinusitis (CRS).
   Methods: A prospective cohort of patients presenting for evaluation of CRS was studied with the Rhinosinusitis Symptom Inventory and the Hospital Anxiety and Depression Scale. Data concerning symptom scores, symptom domains, and psychiatric comorbidity were analyzed with respect to paranasal sinus computed tomography (CT) Lund score. The degree of correlation between sinonasal symptoms and CT scan stage adjusting for anxiety and depression was determined. The relationships between symptoms, psychiatric comorbidity, and the presence of radiographic CRS were determined with multivariate logistic regression.
   Results: There were 230 patients (mean age, 43.4 years) enrolled. High levels of anxiety and depression were noted in 23.5% and 13.0%, respectively. According to CT criteria, 61.3% to 71.3% of patients had true CRS. Even adjusting for anxiety and depression, only the nasal symptom domain severity had a statistically significant correlation with Lund score (r = 0.240; p =.001); facial, oropharyngeal, systemic, and total symptoms did not correlate with CT score. Similarly, multivariate analysis revealed that even with adjustment for anxiety and depression, sinus symptom domains failed to predict radiographic positivity. Individually, only dysosmia, dental pain, and fatigue were predictive for CRS (odds ratios, 1.29 [p =.032], 1.69 [p =.001], and 0.70 [p =.023], respectively).
   Conclusions: Although anxiety and depression are prevalent in patients with CRS, they do not influence the correlation between nasal symptoms and CT findings. Markers of psychiatric comorbidity do not correlate with CRS symptoms. The presence of anxiety or depression does not cloud symptom reporting in CRS and should not bias clinical decision-making.
C1 [Bhattacharyya, Neil] Brigham & Womens Hosp, Div Otolaryngol, Boston, MA 02115 USA.
   [Wasan, Ajay] Brigham & Womens Hosp, Pain Management Ctr, Boston, MA 02115 USA.
   [Wasan, Ajay] Brigham & Womens Hosp, Dept Anesthesia, Boston, MA 02115 USA.
   [Wasan, Ajay] Brigham & Womens Hosp, Dept Psychiat, Boston, MA 02115 USA.
   [Bhattacharyya, Neil] Harvard Univ, Sch Med, Dept Otol & Laryngol, Boston, MA 02115 USA.
   [Wasan, Ajay] Harvard Univ, Sch Med, Dept Anesthesia, Boston, MA 02115 USA.
RP Bhattacharyya, N (reprint author), Brigham & Womens Hosp, Div Otolaryngol, 45 Francis St, Boston, MA 02115 USA.
CR BENSON RH, 1995, PALEOCEANOGRAPHY, V10, P1, DOI 10.1029/94PA02581
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   Bhattacharyya N, 2003, AM J RHINOL, V17, P27
   Bhattacharyya N, 2003, LARYNGOSCOPE, V113, P125, DOI 10.1097/00005537-200301000-00023
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NR 22
TC 8
Z9 11
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD JAN
PY 2008
VL 117
IS 1
BP 18
EP 23
PG 6
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 252NS
UT WOS:000252453800005
PM 18254366
ER

PT J
AU Carpenter, JM
   LaMear, WR
AF Carpenter, Janette M.
   LaMear, William R.
TI Uvulopalatopharyngoplasty: Results of a patient questionnaire
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE apnea; patient satisfaction; questionnaire; snoring;
   uvulopalatopharyngoplasty
ID SATISFACTION; SURGERY
AB Objectives: This study was performed to evaluate patient satisfaction after uvulopalatopharyngoplasty (UPPP).
   Methods: One hundred forty-five patients returned surveys in an otolaryngology group. The patients had undergone UPPP for snoring, sleep apnea, or both between April 1, 2000, and April 5, 2005. Results: Most patients (103; 78%) reported being satisfied with their surgery, and most (96; 71%) stated that they would choose to have the surgery again. Postoperative improvement was reported by 85% of patients who had surgery for snoring alone, 88% of those who had surgery for sleep apnea alone, and 83% of those who had surgery for both. Patients who had a sleep study before surgery had a satisfaction rate of 90.3%, whereas only 62% of those who did not have a sleep study were satisfied. Fifty-three percent of those who had used continuous positive airway pressure still needed it after the operation.
   Conclusions: Most patients who had UPPP were satisfied and would choose to have the surgery again. The most satisfied patients had sleep apnea or sleep apnea and snoring together, as well as a sleep study before surgery. It is important to emphasize that UPPP does not cure everyone of sleep apnea or snoring and that it may not eliminate the need for continuous positive airway pressure.
C1 [Carpenter, Janette M.] Univ So Calif, Dept Otolaryngol, Los Angeles, CA 90033 USA.
   [LaMear, William R.] Tucson Ear Nose & Throat, Tucson, AZ USA.
RP Carpenter, JM (reprint author), Univ So Calif, LA Cty USC Gen Hosp, Dept Otolaryngol, 1200 State St, Los Angeles, CA 90033 USA.
CR Grontved AM, 2000, ACTA OTO-LARYNGOL, P190
   Hassid S, 2002, Acta Otorhinolaryngol Belg, V56, P157
   Hicklin LA, 2000, J LARYNGOL OTOL, V114, P675
   Jones TM, 2005, LARYNGOSCOPE, V115, P2010, DOI 10.1097/01.mlg.0000180178.12972.81
   KATSANTONIS GP, 1990, LARYNGOSCOPE, V100, P138
   MILJETEIG H, 1994, AM J RESP CRIT CARE, V150, P1286
   Prasad KRS, 2003, CLIN OTOLARYNGOL, V28, P497, DOI 10.1046/j.1365-2273.2003.00765.x
   Roosli C, 2006, EUR ARCH OTO-RHINO-L, V263, P754, DOI 10.1007/s00405-006-0051-9
   Tytherleigh MG, 1999, J OTOLARYNGOL, V28, P73
NR 9
TC 0
Z9 0
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD JAN
PY 2008
VL 117
IS 1
BP 24
EP 26
PG 3
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 252NS
UT WOS:000252453800006
PM 18254367
ER

PT J
AU Johnson, K
   Pineda, M
   Darrow, D
   Proud, V
   Derkay, C
AF Johnson, Kaalan
   Pineda, Melissa
   Darrow, David
   Proud, Virginia
   Derkay, Craig
TI Neonatal upper airway obstruction in osteogenesis imperfecta: Series of
   three cases and review of the literature
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE airway obstruction; osteogenesis imperfecta; tracheostomy; tracheotomy
ID PULMONARY HYPOPLASIA; MANAGEMENT; PATIENT
AB Objectives: Osteogenesis imperfecta (OI) is a genetic disorder characterized by variable degrees of dysfunction in type I collagen formation. We sought to explore an association between OI and upper airway obstruction (UAO) in light of our recent experience.
   Methods: We performed a retrospective chart audit and a review of the literature.
   Results: Three consecutive cases of OI at our institution required otolaryngological evaluation for UAO. The first patient had the mildest mutation type and did well until he developed severe reflux-triggered laryngospasm that improved with Nissen fundoplication and gastrostomy tube placement. He had mild hypotonia on endoscopy. The second patient had severe OI and the greatest acute fracture burden at birth. He required tracheotomy after early respiratory failure, and some mild bronchornalacia was noted. The third patient had severe OI and underwent cesarean section delivery. She developed respiratory failure after I month, requiring tracheotomy; mild tracheomalacia and glottic narrowing were noted on endoscopy.
   Conclusions: The UAO consisted of mild hypotonia or malacia in 3 consecutive cases of OI, and may have contributed to pulmonary and mechanical causes of tracheotomy requirement. The greatest predictors of tracheotomy requirement appear to be the severity of the OI mutation and the fracture burden. Elective cesarean section should be considered in severe cases of OI.
C1 [Johnson, Kaalan; Pineda, Melissa; Darrow, David; Derkay, Craig] Eastern Virginia Med Sch, Dept Otolaryngol Head & Neck Surg, Norfolk, VA 23501 USA.
   [Darrow, David; Derkay, Craig] Childrens Hosp Kings Daughters, Div Pediat Otolaryngol, Norfolk, VA USA.
   [Proud, Virginia] Childrens Hosp Kings Daughters, Div Med Genet, Norfolk, VA USA.
RP Johnson, K (reprint author), 128 Beverly Ave, Norfolk, VA 23505 USA.
CR Cubert R, 2001, OBSTET GYNECOL, V97, P66, DOI 10.1016/S0029-7844(00)01100-5
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   Roughley P. J., 2003, European Cells & Materials, V5, P41
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NR 17
TC 2
Z9 2
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD JAN
PY 2008
VL 117
IS 1
BP 27
EP 31
PG 5
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 252NS
UT WOS:000252453800007
PM 18254368
ER

PT J
AU Sautter, NB
   Batra, PS
   Citardi, MJ
AF Sautter, Nathan B.
   Batra, Pete S.
   Citardi, Martin J.
TI Endoscopic management of Sphenoid sinus cerebrospinal fluid leaks
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE cerebrospinal fluid leak; cerebrospinal fluid rhinorrhea; endoscopic
   management; sphenoid sinus
ID LATERAL RECESS; REPAIR; ENCEPHALOCELES; RHINORRHEA; FISTULAS; DEFECTS
AB Objectives: Cerebrospinal fluid (CSF) leaks that originate within the sphenoid sinus pose a unique surgical challenge due to difficulties with access and visualization The objective of this report is to illustrate concepts for the successful management of sphenoid sinus CSF leaks.
   Methods: Retrospective data analysis was performed on 9 patients who presented to a tertiary care medical center for endoscopic repair of a sphenoid sinus CSF leak from January 2002 to January 2006.
   Results: The patient cohort included 7 women and 2 men with a mean age of 51.7 years. In 5 cases the CSF leak was caused by a previous neurosurgical procedure; the other 4 cases were idiopathic. An endoscopic pterygomaxillary fossa approach was required in 4 cases. A layered reconstruction of the sphenoid sinus wall with collagen allografts (cadaveric acellular dermal allograft, 8 patients; bovine collagen membrane, I patient) and mucosa under endoscopic visualization with intraoperative surgical navigation was performed in all cases. The reconstruction was buttressed with autologous bone in 2 cases and with cartilage in 2 cases. Fibrin sealant was used in 7 cases. Two patients developed transient diabetes insipidus after the repair. Two patients developed a recurrent CSF leak necessitating revision repair 2 and 15 months, respectively, after the initial repair procedure. The average hospital stay was 6.5 days. The mean length of follow-up was 21.1 months.
   Conclusions: This series demonstrates that minimally invasive endoscopic repair of sphenoid sinus CSF leaks may be accomplished with an acceptable rate of morbidity and excellent outcomes. Extended endoscopic approaches, including the pterygomaxillary fossa approach, may be useful in selected instances.
C1 [Sautter, Nathan B.; Batra, Pete S.; Citardi, Martin J.] Cleveland Clin Fdn, Head & Neck Inst, Sect Nasal & Sinus Disorders, Cleveland, OH 44195 USA.
RP Citardi, MJ (reprint author), Cleveland Clin Fdn, Head & Neck Inst, Sect Nasal & Sinus Disorders, 9500 Euclid Ave,Desk A71, Cleveland, OH 44195 USA.
CR Al-Nashar IS, 2004, LARYNGOSCOPE, V114, P528, DOI 10.1097/00005537-200403000-00026
   Bolger WE, 2005, OTOLARYNG HEAD NECK, V133, P20, DOI 10.1016/j.otohns.2005.03.063
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NR 23
TC 15
Z9 20
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD JAN
PY 2008
VL 117
IS 1
BP 32
EP 39
PG 8
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 252NS
UT WOS:000252453800008
PM 18254369
ER

PT J
AU Lorenz, RR
   Esclamado, RM
   Teker, AA
   Strome, M
   Scharpf, J
   Hicks, D
   Milstein, C
   Lee, WT
AF Lorenz, Robert R.
   Esclamado, Ramon M.
   Teker, Aysenur A.
   Strome, Marshall
   Scharpf, Joseph
   Hicks, Douglas
   Milstein, Claudio
   Lee, Walter T.
TI Ansa cervicalis-to-recurrent laryngeal nerve anastomosis for unilateral
   vocal fold paralysis: Experience of a single institution
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE ansa cervicalis; recurrent laryngeal nerve; surgical anastomosis;
   unilateral vocal fold paralysis
ID CORD PARALYSIS; REINNERVATION
AB Objectives: One treatment option for unilateral vocal fold paralysis (UVFP) is ansa cervicalis-to-recurrent laryngeal nerve (ansa-RLN) anastomosis to provide reinnervation to the affected vocal fold. The advantages of this treatment approach are that it 1) provides vocal fold tone, bulk, and tension, 2) is technically simple, and 3) does not preclude other medialization procedures. We present all patients who have undergone ansa-RLN anastomosis for UVFP at our institution.
   Methods: An Institutional Review Board-approved retrospective chart review was performed to include all patients who had undergone an ansa-RLN anastomosis procedure for UVFP at our institution. Data from clinical and endoscopic laryngoscopy with stroboscopy were recorded. Statistical analysis was performed on visual and perceptual vocal data.
   Results: A total of 46 patients were included in the study. Stroboscopic analysis and perceptual vocal evaluation was performed in a blinded fashion on the 21 patients who had preoperative and postoperative stroboscopy. Severity, roughness, breathiness, and strain all improved significantly over time. Glottic closure, vocal fold edge, and supraglottic effort all significantly improved after operation. Of the 38 patients with at least 3 months of follow-up, all except I demonstrated evidence of reinnervation.
   Conclusions: This technique for treating UVFP results in significant improvements in patients' voice and on visual examination.
C1 [Lorenz, Robert R.; Teker, Aysenur A.; Strome, Marshall; Scharpf, Joseph; Hicks, Douglas; Milstein, Claudio; Lee, Walter T.] Cleveland Clin, Head & Neck Inst, Cleveland, OH 44106 USA.
   [Esclamado, Ramon M.] Duke Univ, Div Otolaryngol Head & Neck Surg, Durham, NC USA.
RP Lee, WT (reprint author), Desk A71,9500 Euclid Ave, Cleveland, OH 44195 USA.
CR Chhetri DK, 1997, LARYNGOSCOPE, V107, P1366, DOI 10.1097/00005537-199710000-00014
   CRUMLEY RL, 1988, LARYNGOSCOPE, V98, P1200
   CRUMLEY RL, 1986, LARYNGOSCOPE, V96, P611
   CRUMLEY RL, 1991, LARYNGOSCOPE, V101, P384
   Lee WT, 2007, OTOLARYNG HEAD NECK, V136, P450, DOI 10.1016/j.otohns.2006.11.040
   Maronian N, 2003, ANN OTO RHINOL LARYN, V112, P314
   Miyauchi A, 1998, EUR J SURG, V164, P927
   Olson DEL, 1998, LARYNGOSCOPE, V108, P1767, DOI 10.1097/00005537-199812000-00002
   Paniello RC, 2004, OTOLARYNG CLIN N AM, V37, P161, DOI 10.1016/S0030-6665(03)00164-6
   Spector BC, 2001, OTOLARYNG HEAD NECK, V125, P176, DOI 10.1067/mhn.2001.117714
   Su WF, 2007, J AM COLL SURGEONS, V204, P64, DOI 10.1016/j.jamcollsurg.2006.08.028
   Toth A, 2005, OTOLARYNG HEAD NECK, V132, P701, DOI 10.1016/j.otohns.2005.01.045
   Zealear DL, 2004, OTOLARYNG CLIN N AM, V37, P1, DOI 10.1016/S0030-6665(03)00165-8
NR 13
TC 27
Z9 28
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD JAN
PY 2008
VL 117
IS 1
BP 40
EP 45
PG 6
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 252NS
UT WOS:000252453800009
PM 18254370
ER

PT J
AU Gilbey, P
   Gadban, H
   Letichevsky, V
   Talmon, Y
AF Gilbey, Peter
   Gadban, Hussain
   Letichevsky, Vadim
   Talmon, Yoav
TI Harmonic scalpel tonsillectomy using the curved shears instrument versus
   cold dissection tonsillectomy: a retrospective study
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE electrocautery; harmonic scalpel; postoperative complication;
   tonsillectomy
ID ULTRASONICALLY ACTIVATED SCALPEL; POST-TONSILLECTOMY; BLUNT DISSECTION;
   ELECTROCAUTERY
AB Objectives: We compared operating time, intraoperative blood loss, and rate of postoperative bleeding in harmonic scalpel (HS) tonsillectomy using the curved shears instrument to those in cold dissection (CD) tonsillectomy.
   Methods: The charts of 560 patients who underwent tonsillectomy were retrospectively reviewed. Three hundred nineteen patients underwent CD tonsillectomy between the years 1998 and 1999, and 241 patients underwent HS tonsillectomy using the curved shears instrument between the years 2001 and 2005. For the purpose of evaluation of postoperative bleeding rates, the groups were further stratified by age (11 years of age or less versus 12 years of age or more).
   Results: For the HS group, the mean operating time was shorter (7 minutes versus 17.57 minutes) and the intraoperative blood loss was lower (0 mL versus 42.12 mL). These differences were statistically significant (p <.05). There was no significant difference in the overall postoperative bleeding rates between the two groups. The postoperative bleeding rate in the HS patients I I years of age or younger was lower than that in the equivalent age group in the CD group (0.56% versus 2%, respectively), although this difference did not reach statistical significance. The postoperative bleeding rate in the HS patients 12 years of age or older was significantly higher than that in the equivalent age group in the CD group (7.93% versus 1%, respectively; p <.05).
   Conclusions: Harmonic scalpel tonsillectomy using the curved shears instrument offers advantages over CD tonsillectomy regarding operating time and intraoperative blood loss. In our patients more than 12 years of age, HS tonsillectomy using the curved shears instrument was associated with an increased postoperative bleeding rate compared to CD tonsillectomy.
C1 [Gilbey, Peter; Gadban, Hussain; Letichevsky, Vadim; Talmon, Yoav] Western Galilee Hosp, Dept Otolaryngol Head & Neck Surg, IL-22100 Nahariyya, Israel.
RP Gilbey, P (reprint author), Western Galilee Hosp, Dept Otolaryngol Head & Neck Surg, POB 21, IL-22100 Nahariyya, Israel.
CR Akural EI, 2001, ANAESTHESIA, V56, P1045, DOI 10.1046/j.1365-2044.2001.02275.x
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   Msika S, 2001, DIS COLON RECTUM, V44, P432, DOI 10.1007/BF02234745
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   Walker RA, 2001, OTOLARYNG HEAD NECK, V125, P449, DOI 10.1067/mhn.2001.119325
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   Windfuhr JP, 2003, ANN OTO RHINOL LARYN, V112, P63
NR 21
TC 4
Z9 5
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD JAN
PY 2008
VL 117
IS 1
BP 46
EP 50
PG 5
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 252NS
UT WOS:000252453800010
PM 18254371
ER

PT J
AU Hattori, R
   Shimizu, S
   Majima, Y
   Shimizu, T
AF Hattori, Reiko
   Shimizu, Shino
   Majima, Yuichi
   Shimizu, Takeshi
TI EN agonist inhibits lipopolysaccharide-induced mucus secretion in airway
   epithelial cells
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE cell culture; goblet cell; nose; prostaglandin E2; rat
ID RAT NASAL EPITHELIUM; MONOCLONAL-ANTIBODY; PROSTAGLANDIN E-2; DENDRITIC
   CELLS; GOBLET CELLS; SOLUBLE CD14; RECEPTORS; NEUTROPHILS; EXPRESSION;
   MUCIN
AB Objectives: We examined the in vivo effects of agonists for prostaglandin E2 receptors (EP1, EP2, EP3, and EP4) on mucus hypersecretion. We also examined the in vitro effects of EP agonists on airway epithelial cells.
   Methods: For the in vivo study, we induced hypertrophic and metaplastic changes of goblet cells in rat nasal epithelium by intranasal lipopolysaccharide (LPS) instillation. For the in vitro study, we used NCI-H292 cells and cultured human nasal epithelial cells.
   Results: Subcutaneous injection of the EP4 agonist (1 to 100 mu g/kg) dose-dependently inhibited LPS-induced mucus production and neutrophil infiltration. The EP3 agonist (100 mu g/kg) also had some inhibitory effects on mucus production, whereas the EP1 and EP2 agonists showed no effect. The LPS-induced mucus secretion was significantly inhibited by the EP3 and EP4 agonists at 10(-6) mol/L in cultured epithelial cells. The LPS-induced interleukin-8 secretion was also inhibited by the EP3 and EP4 agonists.
   Conclusions: These results indicate that the EP4 agonist inhibited LPS-induced airway mucus hypersecretion directly or indirectly through the suppression of interleukin-8 secretion and neutrophil infiltration.
C1 [Shimizu, Shino; Shimizu, Takeshi] Shiga Univ Med Sci, Dept Otorhinolaryngol, Otsu, Shiga 5202192, Japan.
   [Hattori, Reiko; Majima, Yuichi] Mie Univ, Sch Med, Dept Otorhinolaryngol Head & Neck Surg, Tsu, Mie 514, Japan.
RP Shimizu, T (reprint author), Shiga Univ Med Sci, Dept Otorhinolaryngol, Otsu, Shiga 5202192, Japan.
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NR 25
TC 7
Z9 7
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD JAN
PY 2008
VL 117
IS 1
BP 51
EP 58
PG 8
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 252NS
UT WOS:000252453800011
PM 18254372
ER

PT J
AU Nomoto, Y
   Kobayashi, K
   Tada, Y
   Wada, I
   Nakamura, T
   Omori, K
AF Nomoto, Yukio
   Kobayashi, Ken
   Tada, Yasuhiro
   Wada, Ikuo
   Nakamura, Tatsuo
   Omori, Koichi
TI Effect of fibroblasts on epithelial regeneration on the surface of a
   bioengineered trachea
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE epithelium; fibroblast; regeneration; tissue engineering; trachea
ID HUMAN KERATINOCYTE GROWTH; IN-VITRO; CELLS
AB Objectives: Our group applied a tracheal prosthesis, which was composed of polypropylene as the frame and collagenous sponge as the scaffold, to the first human case and had successful results. The objective of this study was to find a way to acquire more rapid re-epithelialization with fibroblasts on this tracheal prosthesis.
   Methods: Tracheal epithelial cells, which were isolated from the trachea of rats, were suspended in a collagenous gel. The collagenous gel with fibroblasts was layered on a collagenous sponge. The grafts of this "bioengineered trachea" were implanted into tracheal defects of rats, and the regenerated epithelium on the grafts was histologically examined.
   Results: Seven days after implantation, stratified squamous epithelium covered almost all of the surface of the gel, and some of the implanted fibroblasts in the gel were lined up just below the epithelium. Fourteen days after implantation, columnar and cuboidal ciliated epithelium covered almost all of the surface of the defects, and the implanted fibroblasts had disappeared. The numbers of regenerated epithelial cells at 14 days after implantation were larger than those of control models without fibroblasts, with statistical significance.
   Conclusions: The results suggested that the grafts of bioengineered trachea composed of collagenous sponge and collagenous gel with tracheal fibroblasts accelerated epithelial differentiation and proliferation in vivo.
C1 [Nomoto, Yukio; Kobayashi, Ken; Tada, Yasuhiro; Omori, Koichi] Fukushima Med Univ, Sch Med, Dept Otolaryngol, Fukushima 9601295, Japan.
   [Wada, Ikuo] Fukushima Med Univ, Sch Med, Inst Biomed Sci, Dept Cell Sci, Fukushima 9601295, Japan.
   [Nakamura, Tatsuo] Kyoto Univ, Inst Frontier Med Sci, Dept Bioartificial Organs, Kyoto, Japan.
RP Nomoto, Y (reprint author), Fukushima Med Univ, Sch Med, Dept Otolaryngol, 1 Hikarigaoka, Fukushima 9601295, Japan.
CR Akagi T, 2003, P NATL ACAD SCI USA, V100, P13567, DOI 10.1073/pnas.1834876100
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   Kobayashi K, 2006, TISSUE ENG, V12, P2619, DOI 10.1089/ten.2006.12.2619
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   Nomoto Y, 2006, ANN OTO RHINOL LARYN, V115, P501
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NR 15
TC 15
Z9 16
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD JAN
PY 2008
VL 117
IS 1
BP 59
EP 64
PG 6
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 252NS
UT WOS:000252453800012
PM 18254373
ER

PT J
AU Tateya, T
   Tateya, I
   Surles, RL
   Tanumihardjo, S
   Bless, DM
AF Tateya, Tomoko
   Tateya, Ichiro
   Surles, Rebecca Lynn
   Tanumihardjo, Sherry
   Bless, Diane M.
TI Roles of vitamin a and macula flava in maintaining vocal folds
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE extracellular matrix; stellate cell; vitamin A; vocal fold
ID HEPATIC STELLATE CELLS; RETINOIC ACID; LIVER FIBROSIS; RAT; DEPLETION;
   MICE
AB Objectives: Vitamin A plays important roles in development, growth, and regeneration. Vitamin A-storing stellate cells have been identified in several organs. The functional roles of vitamin A in the vocal folds are still unknown, although vitamin A-storing vocal fold stellate cells have been observed in the macula flava of human and rat vocal folds. The purpose of this study was to investigate the roles of vitamin A in vocal folds.
   Methods: Vitamin A-deficient rats were generated, and the vocal folds were examined histologically. Messenger RNA was extracted from the vocal folds and analyzed by real-time polymerase chain reaction.
   Results: Inummohistochemical analysis of normal vocal folds revealed expression of retinoic acid receptor a in vocal fold stellate cells. The cells in the macula flava of vitamin A-deficient rats showed a larger nucleus/cytoplasm ratio than did those of vitamin A-sufficient rats, but messenger RNA expression of major extracellular matrix components in the macula flava of vitamin A-deficient rats did not present a remarkable change except for procollagen type I. Expression of hyaluronic acid, collagen types I and III, and elastin did not show a significant change in vitamin A-deficient rat vocal folds.
   Conclusions: These results indicate that vitamin A is not essential to maintaining the extracellular matrix of normal adult vocal folds, although vocal fold stellate cells participate in vitamin A storage.
C1 [Tateya, Ichiro] Kyoto Katsura Hosp, Dept Otolaryngol, Nishikyo Ku, Kyoto 6158256, Japan.
   [Tateya, Tomoko] Kyoto Univ, Grad Sch Med, Dept Otolaryngol Head & Neck Surg, Kyoto, Japan.
   [Tateya, Tomoko; Tateya, Ichiro; Bless, Diane M.] Univ Wisconsin, Dept Surg, Div Otolaryngol Head & Neck Surg, Madison, WI USA.
   [Surles, Rebecca Lynn; Tanumihardjo, Sherry] Univ Wisconsin, Dept Nutr Sci, Madison, WI 53706 USA.
RP Tateya, I (reprint author), Kyoto Katsura Hosp, Dept Otolaryngol, Nishikyo Ku, 17 Yamada Hirao Cho, Kyoto 6158256, Japan.
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   Dickman ED, 1997, DEVELOPMENT, V124, P3111
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NR 18
TC 5
Z9 5
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD JAN
PY 2008
VL 117
IS 1
BP 65
EP 73
PG 9
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 252NS
UT WOS:000252453800013
PM 18254374
ER

PT J
AU Isenberg, JS
   Crozier, DL
   Dailey, SH
AF Isenberg, Jason S.
   Crozier, Daniel L.
   Dailey, Seth H.
TI Institutional and comprehensive review of laryngeal leukoplakia
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE human; laryngeal dysplasia; larynx; leukoplakia; vocal fold
ID FOLLOW-UP; PREMALIGNANT LESIONS; INVASIVE-CARCINOMA; DYSPLASIA;
   KERATOSIS; CANCER; TRANSFORMATION; HYPERPLASIA; EXPRESSION; EVOLUTION
AB Objectives: The nature and interpretation of vocal fold leukoplakia has been limited by small study sizes. The present study reviewed institutional data and the published literature to better characterize vocal fold leukoplakia.
   Methods: At our institution, the histopathology, age, and malignant conversion rates of 136 patients (208 biopsies) with vocal fold leukoplakia from 1990 to 2005 were reviewed.
   Results: No dysplasia (ND), mild and/or moderate dysplasia (MM), and severe dysplasia and/or squamous cell carcinoma in situ (SS) was identified in, respectively, 110 of 208 (53%), 38 of 208 (18%), and 31 of 208 (15%) biopsies. After 30 months (range, 1 to 134 months), malignant transformation was observed in 8 patients on subsequent biopsies. Additionally, a literature search was performed from 1960 to 2005 for the medical subject headings (MeSH) premalignant laryngeal lesions, laryngeal dysplasia, laryngeal leukoplakia, vocal cord dysplasia, and hyperkeratosis of the larynx. Fifteen reports were included for review. When these were combined with our institutional data, 1,173 of 2,188 biopsies (53.6%) revealed ND. Mild and/or moderate dysplasia and SS were present in 717 of 2,140 (33.5%) and 375 of 2,471 (15.2%) biopsies, respectively. Squamous cell carcinoma developed in 52 of 1,388 (3.7%), 83 of 824 (10.1%), and 56 of 310 (18.1%) patients whose initial biopsies demonstrated ND, MM, or SS.
   Conclusions: More than half of the reported leukoplakia lesions with biopsies showed ND. However, even lesions characterized as ND were associated with an increased risk of development of squamous cell carcinoma. Importantly, the risk of developing malignancy appears to correlate with the severity of dysplasia present on initial biopsy. Because clinical examination does not accurately predict the risk of malignancy, future studies, including genomic evaluation of this lesion, may be necessary to further characterize its biologic behavior.
C1 [Isenberg, Jason S.; Crozier, Daniel L.; Dailey, Seth H.] Univ Wisconsin, Dept Surg, Div Otolaryngol Head & Neck Surg, Madison, WI 53792 USA.
RP Dailey, SH (reprint author), Univ Wisconsin, Dept Surg, Div Otolaryngol Head & Neck Surg, 600 Highland Ave,CSC K4-714, Madison, WI 53792 USA.
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NR 31
TC 28
Z9 31
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD JAN
PY 2008
VL 117
IS 1
BP 74
EP 79
PG 6
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 252NS
UT WOS:000252453800014
PM 18254375
ER

PT J
AU McCabe, BF
AF McCabe, Brian F.
TI Autoimmune sensorineural hearing loss
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
AB The author proposes the existence of a new entity, autoimmune sensorineural hearing loss, on the basis of diagnostic study and treatment experience with a series of 18 patients. In each case the clinical pattern did not fit with known entities and thus seemed to merit distinctive categorization. In the one patient in whom tissue was available, a vasculitis was evident, a feature of autoinimune disease. All patients responded to treatment for an autoinimune disease, namely, chronic cortisone and cyclophosphamide therapy. The author suggests that all otolaryngologists should be aware of the possibility of this condition, because it is one of the few forms of sensorineural deafness for which we have a treatment.
C1 [McCabe, Brian F.] Univ Iowa Hosp & Clin, Dept Otolaryngol & Maxillofacial Surg, Iowa City, IA 52242 USA.
RP McCabe, BF (reprint author), Univ Iowa Hosp & Clin, Dept Otolaryngol & Maxillofacial Surg, Iowa City, IA 52242 USA.
CR SHILLING B, 1974, BLOOD SUPPLY EXTERNA
NR 1
TC 4
Z9 4
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD DEC
PY 2007
VL 116
IS 12
BP 875
EP 879
PG 5
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 243VI
UT WOS:000251825000002
PM 18217503
ER

PT J
AU McCabe, BF
   Harker, LA
AF McCabe, Brian F.
   Harker, Lee A.
TI Vascular loop as a cause of vertigo
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
AB A vascular loop in the internal auditory canal pressing upon the vestibular nerve was found in a series of eight patients with episodic vertigo and severe motion intolerance. All patients had failed medical and surgical therapy for vestibular Meniere's disease, which this syndrome closely mimics. A vestibular nerve resection or section medial to the vascular loop produced relief of symptoms in all patients, but one patient required a second operation. We have no test or study to reliably diagnose this syndrome preoperatively. The history appears to be the best indicator to date.
C1 [McCabe, Brian F.; Harker, Lee A.] Univ Iowa Hosp & Clin, Dept Otolaryngol Head & Neck Surg, Iowa City, IA 52242 USA.
RP McCabe, BF (reprint author), Univ Iowa Hosp & Clin, Dept Otolaryngol Head & Neck Surg, Iowa City, IA 52242 USA.
CR Janetta PJ, 1975, SURG FORUM, V26, P467
   LECLERCQ TA, 1980, LARYNGOSCOPE, V90, P1011
   MAZZONI A, 1970, ARCHIV OTOLARYNGOL, V91, P128
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NR 4
TC 0
Z9 0
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD DEC
PY 2007
VL 116
IS 12
BP 880
EP 881
PG 2
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 243VI
UT WOS:000251825000003
PM 18217504
ER

PT J
AU Brenner, MJ
   Floyd, L
   Collins, SL
AF Brenner, Michael J.
   Floyd, Larry
   Collins, Sharon L.
TI Role of computed tomography and bronchoscopy in speech prosthesis
   aspiration
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE alaryngeal speech; aspiration; bronchoscopy; foreign body; laryngectomy;
   prosthesis; tracheoesophageal puncture.
ID TRACHEOESOPHAGEAL PUNCTURE; VOICE REHABILITATION; FOREIGN-BODIES;
   LARYNGECTOMY; RESTORATION; COMPLICATIONS; EXPERIENCE; INSERTION;
   ABSCESS; ADULTS
AB Tracheoesophageal puncture prostheses (TEPPs) are an integral aspect of speech rehabilitation for many patients who have under-one total laryngectomy. Because one flange of the prosthesis sits in the trachea and the other in the esophagus. these devices can be aspirated or swallowed if dislodged. Five cases of prosthesis aspiration that occurred in 4 veterans within a 16-month period are described. The 5 aspirated TEPPs resulted in highly variable clinical presentations ranging from complaints of "lost" TEPPs in asymptomatic patients to near-asphyxiation. Furthermore, the aspirated TEPPs were not reliably demonstrated on chest radiographs, often leading to delayed diagnosis. Aspiration of TEPPs may be more common than formerly recognized, and chest computed tomography or bronchoscopy is indicated in cases of missing TEPPs not demonstrated on plain films.
C1 [Brenner, Michael J.; Collins, Sharon L.] Univ Washington, Sch Med, Dept Otolaryngol Head & Neck Surg, Seattle, WA 98195 USA.
   [Floyd, Larry; Collins, Sharon L.] John Cochran Vet Adm Med Ctr, Otolaryngol Sect Head & Nechk Surg, St Louis, MO USA.
RP Collins, SL (reprint author), Dept Otolaryngol Head & Neck Surg, Campus Box 8115, St Louis, MO 63110 USA.
CR ANDREWS JC, 1987, LARYNGOSCOPE, V97, P562
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NR 22
TC 4
Z9 4
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD DEC
PY 2007
VL 116
IS 12
BP 882
EP 886
PG 5
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 243VI
UT WOS:000251825000004
PM 18217505
ER

PT J
AU Vibert, D
   Redfield, RC
   Hausler, R
AF Vibert, Dominique
   Redfield, Robin C.
   Hausler, Rudolf
TI Benign paroxysmal positional vertigo in mountain bikers
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE benign paroxysmal positional vertigo; inner ear; mountain bike;
   otoconia; sport; vertigo
ID BIKING INJURIES; TRAUMA
AB We evaluated 4 men who had benign paroxysmal positional vertigo (BPPV) that occured several hours after intensive mountain biking but without head trauma. The positional maneuvers in the planes of the posterior and horizontal canals elicited BPPV, as well as transitory nystagmus. This was attributed to both the posterior and horizontal semicircular canals (SCCs) on the left side in 1 patient, in these 2 SCCs on the right side in another patient, and to the right posterior SCC in the other 2 patients. The symptoms disappeared after physiotherapeutic maneuvers in 2 patients and spontaneously in the other 2 patients. Cross-country or downhill mountain biking generates frequent vibratory impacts, which are only partially filtered through the suspension fork and the upper parts of the body. Biomechanically, during a moderate jump, before landing, the head is subjected to an acceleration close to negative 1g, and during impact it is subjected to an upward acceleration of more than 2g. Repeated acceleration-deceleration events during intensive off-road biking might generate displacement and/or dislocation of otoconia from the otolithic organs, inducing the typical symptoms of BPPV. This new cause of posttraumatic BPPV should be considered as an injury of minor severity attributed to the practice of mountain biking.
C1 [Vibert, Dominique; Hausler, Rudolf] Univ Bern, Inselspital, Dept Otolaryngol Head & Neck Surg, CH-3010 Bern, Switzerland.
   [Redfield, Robin C.] USAF Acad, Dept Engn Mech, Colorado Springs, CO USA.
RP Vibert, D (reprint author), Univ Bern, Inselspital, Dept ENT Head & Neck Surg, CH-3010 Bern, Switzerland.
CR BALOH RW, 1987, NEUROLOGY, V37, P371
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   Kim PTW, 2006, J TRAUMA, V60, P312, DOI 10.1097/01.ta.0000202714.31780.5f
   Kronisch RL, 2002, CLIN J SPORT MED, V12, P158, DOI 10.1097/01.JSM.0000017378.22348.45
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NR 17
TC 4
Z9 4
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD DEC
PY 2007
VL 116
IS 12
BP 887
EP 890
PG 4
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 243VI
UT WOS:000251825000005
PM 18217506
ER

PT J
AU Holden, PK
   Vokes, DE
   Taylor, MB
   Till, JA
   Crumley, RL
AF Holden, Paul K.
   Vokes, David E.
   Taylor, Michael B.
   Till, James A.
   Crumley, Roger L.
TI Long-term botulinum toxin dose consistency for treatment of adductor
   spasmodic dysphonia
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE adductor; botulinum toxin; dose; laryngeal dystonia; spasmodic dysphonia
ID LARYNGEAL NERVE-SECTION; SPASTIC DYSPHONIA; DYSTONIA; THERAPY;
   INJECTIONS; EXPERIENCE; MANAGEMENT; RESISTANCE; MUSCLE
AB Objectives: Botulinum toxin (BTX) injection is currently the primary and most common treatment for adductor spasmodic dysphonia (ADSD). A variety of injection strategies and dosage regimens have been described. This study reports on our experience with the dosage schedule and dosing consistency of BTX for the treatment of ADSD.
   Methods: We retrospectively reviewed our laryngeal BTX database for the period 1991 to 2005. Our strict inclusion requirements limited our selection to 13 patients who had received a minimum of 6 injections (average, 11.5; range, 6 to 19) of BTX for ADSD.
   Results: The average total dose of BTX to the larynx for each treatment episode was 3.9 units (range, 1.5 to 7.5). The total dose administered tended to trend downward among patients who began treatment from 1991 to 1998, indicating that the initial dose (usually 2.5 units per side) may have been high. Those patients who began from 1999 onward had a more stable dose, indicating that the initial dose (usually 1.5 units per side) was more suitable. The subjects underwent an average of 2.2 injections (range, 1 to 5) before reaching their optimal BTX dose. The total number of treatments performed in this group of patients was 150, of which 145 were successful (96.7%).
   Conclusions: The BTX dose for the optimal treatment of ADSD usually remains consistent over time, as does the treatment interval. An initial dose of 1.5 units per side or less appears to improve dosing stability, indicating that the initial dosing of 2.5 units per side in our study was often greater than required. The optimal BTX dose was usually ascertained by the second or third injection. In our patient population, the long-term dosing consistency of BTX confirmed that neither tachyphylaxis nor increasing sensitivity to BTX occurred during the course of treatment for ADSD.
C1 [Holden, Paul K.; Vokes, David E.; Taylor, Michael B.; Till, James A.; Crumley, Roger L.] Univ Calif Irvine, Dept Otolaryngol Head & Neck Surg, Orange, CA 92868 USA.
RP Crumley, RL (reprint author), Univ Calif Irvine, Dept Otolaryngol Head & Neck Surg, 100 The City Dr,Bldg 56,Suite 500, Orange, CA 92868 USA.
CR *AM AC OT HEAD NEC, 2006, POL STAT BOT TOX
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NR 30
TC 14
Z9 15
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD DEC
PY 2007
VL 116
IS 12
BP 891
EP 896
PG 6
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 243VI
UT WOS:000251825000006
PM 18217507
ER

PT J
AU Fujimoto, C
   Ito, K
   Takano, S
   Karino, S
   Iwasaki, S
AF Fujimoto, Chisato
   Ito, Ken
   Takano, Shingo
   Karino, Shotaro
   Iwasaki, Shinichi
TI Successful cochlear implantation in a patient with bilateral progressive
   sensorineural hearing loss after traumatic subarachnoid Hemorrhage and
   brain contusion
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE bilateral progressive sensorineural hearing loss; brain contusion;
   cochlear implantation; head trauma; subarachnoid hemorrhage
ID CENTRAL-NERVOUS-SYSTEM; SUPERFICIAL SIDEROSIS; INTRACRANIAL HYPOTENSION
AB Objectives: We address the proper indications for cochlear implantation for profound deafness with possible retrocochlear involvement by reporting successful implantation in a patient with traumatic subarachnoid hemorrhage and brain contusion.
   Methods: We present a patient (55-year-old man) who had bilateral progressive sensorineural hearing loss after traumatic subarachnoid hemorrhage and brain contusion. Preoperative imaging and functional studies were done, as well as routine tests, to evaluate the possible performance of the cochlear implant.
   Results: Sensorineural hearing loss developed promptly after head trauma with progressive deterioration. The cause of progressive sensorineural hearing loss remained unknown. Distortion product otoacoustic emissions demonstrated bilateral inner ear (outer hair cell) damage. Highly impaired speech discrimination despite less marked pure tone average elevation and a focal lesion in the left middle temporal gyrus suggested the possibility of coexisting retrocochlear lesions. After thorough discussion of the possible outcomes, cochlear implantation was successfully performed 25 months after the trauma. The patient became able to use a telephone.
   Conclusions: We advocate that profound bilateral sensorineural hearing loss caused by traumatic head injury, even with possible involvement of central auditory pathways, should not be regarded as a contraindication to cochlear implantation, as long as bilateral inner ear dysfunction is clearly demonstrated and there is no obvious evidence of central deafness.
C1 [Fujimoto, Chisato; Ito, Ken; Takano, Shingo; Karino, Shotaro; Iwasaki, Shinichi] Univ Tokyo, Fac Med, Dept Otolaryngol, Tokyo, Japan.
RP Ito, K (reprint author), Univ Tokyo, Fac Med, Dept Otolaryngol, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1138655, Japan.
CR Bergemalm PO, 2003, ACTA OTO-LARYNGOL, V123, P836, DOI 10.1080/00016480310002474
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   Maas S, 1996, J LARYNGOL OTOL, V110, P881
   Moore A, 1999, J Laryngol Otol Suppl, V24, P34
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   Portier F, 2002, ANN OTO RHINOL LARYN, V111, P817
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NR 14
TC 4
Z9 4
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD DEC
PY 2007
VL 116
IS 12
BP 897
EP 901
PG 5
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 243VI
UT WOS:000251825000007
PM 18217508
ER

PT J
AU Daudia, A
   Biswas, D
   Jones, NS
AF Daudia, Anu
   Biswas, Debabrata
   Jones, Nick S.
TI Risk of meningitis with cerebrospinal fluid rhinorrhea
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE cerebrospinal fluid; meningitis; rhinorrhea
ID PROPHYLACTIC ANTIBIOTICS; ENDOSCOPIC REPAIR; METAANALYSIS; MANAGEMENT;
   FISTULAS; EFFICACY; LEAKS
AB Objectives: The annual risk of meningitis in unrepaired fistulas is widely quoted to be approximately 10% per annum. Our aim was to review our experience with cerebrospinal fluid (CSF) leaks and to calculate the overall risk and the annual incidence of meningitis, and to correlate our findings with the causation and the effect of operative intervention in a subgroup of patients who had a history of meningitis.
   Methods: We prospectively collected data on all patients referred with a CSF leak to our tertiary referral center over a 12-year period between 1994 and 2006. We had a follow-up rate of 91%.
   Results: One hundred eleven patients had a proven leak on endoscopy, beta-2 transferrin, imaging, and/or fluorescein lumbar puncture. The accumulated duration of an active CSF leak in the cohort was 190 years. The total number of episodes of meningitis was 57 in 21 patients, giving an overall risk of developing meningitis of 19%, with an overall incidence of 0.3 episodes per year. There was a progressive reduction in the incidence of meningitis with time, and most episodes occurred within the first year following the onset of the CSF leak. However, the risk persisted as long as the CSF leak was active.
   Conclusions: The overall risk of meningitis in patients with persistent CSF rhinorrhea was 19%. The annual incidence of meningitis was 0.3 episodes per year, with most episodes occurring within the first year following the onset of the leak. Endoscopic closure is the treatment of choice in most CSF leaks; if successful, it reduces the risk of meningitis.
C1 [Daudia, Anu; Biswas, Debabrata; Jones, Nick S.] Univ Nottingham, Queens Med Ctr, Dept Otolaryngol Head & Neck Surg, Nottingham NG7 2RD, England.
RP Jones, NS (reprint author), Queens Med Ctr, Dept Otolaryngol Head & Neck Surg, Nottingham NG7 2UH, England.
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NR 18
TC 23
Z9 24
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD DEC
PY 2007
VL 116
IS 12
BP 902
EP 905
PG 4
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 243VI
UT WOS:000251825000008
PM 18217509
ER

PT J
AU Cankurtaran, M
   Celik, H
   Coskun, M
   Hizal, E
   Cakmak, O
AF Cankurtaran, Mehmet
   Celik, Huseyin
   Coskun, Mehmet
   Hizal, Evren
   Cakmak, Ozcan
TI Acoustic rhinometry in healthy humans: Accuracy of area estimates and
   ability to quantify certain anatomic structures in the nasal cavity
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE acoustic rhinometry; computed tomography; nasal cavity; nasal valve;
   paranasal sinus; turbinate
ID PARANASAL SINUSES; PASSAGE AREA; MODELS; REFLECTIONS; VOLUME; VALVE
AB Objectives: We evaluated the accuracy of acoustic rhinometry (AR) measurements in healthy humans and assessed the ability of AR in quantifying the dimensions of the paranasal sinuses and certain anatomic structures in the nasal cavity.
   Methods: Twenty nasal passages of 10 healthy adults were examined by AR and computed tomography (CT) before and after decongestion. Actual cross-sectional areas of the nasal cavity and actual locations of the nasal valve, the head of the inferior turbinate, the head of the middle turbinate, the ostia of the frontal and maxillary sinuses, and the choana were determined from CT sections perpendicular to the curved acoustic axis of the nasal passage.
   Results: The AR-measured cross-sectional areas in the anterior nasal cavity were in reasonable agreement with the corresponding areas determined from CT, whereas AR consistently overestimated the passage areas at locations posterior to the paranasal sinus ostia. The nasal valve was identified as a pronounced minimum on the AR area-distance curve. However, AR did not discretely identify the head of the inferior turbinate, the head of the middle turbinate, or the choana.
   Conclusions: The local minima on the AR area-distance curve beyond the nasal valve are caused by acoustic resonances in the nasal cavity, and do not correspond to any anatomic structure. The AR area overestimation beyond the paranasal sinus ostia is due to the interaction between the nasal cavity and the paranasal sinuses, rather than to sound loss into the sinuses. Acoustic rhinometry provides no quantitative information on ostium size or sinus volume in either non-deconested or deconested nasal cavities.
C1 [Cankurtaran, Mehmet; Celik, Huseyin] Univ Hacettepe, Fac Engn, Dept Phys, Ankara, Turkey.
   [Coskun, Mehmet] Baskent Univ, Fac Med, Dept Radiol, Ankara, Turkey.
   [Hizal, Evren; Cakmak, Ozcan] Baskent Univ, Fac Med, Dept Otorhinolaryngol, Ankara, Turkey.
RP Cakmak, O (reprint author), Baskent Univ Hastanesi, Kulak Burun Bogaz Anabilim Dali, Bahcelievler, T-06490 Ankara, Turkey.
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NR 26
TC 18
Z9 21
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD DEC
PY 2007
VL 116
IS 12
BP 906
EP 916
PG 11
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 243VI
UT WOS:000251825000009
PM 18217510
ER

PT J
AU Broadhurst, MS
   Kobler, JB
   Burns, JA
   Anderson, RR
   Zeitels, SM
AF Broadhurst, Matthew S.
   Kobler, James B.
   Burns, James A.
   Anderson, R. Rox
   Zeitels, Steven M.
TI Chick chorioallantoic membrane as a model for simulating human true
   vocal folds
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE chorioallantoic membrane; KTP laser; larynx; laser; phonosurgery; pulsed
   dye laser; vocal cord; vocal fold
ID LASER TREATMENT; PAPILLOMATOSIS; DYSPLASIA
AB Objectives: Evolving photoangiolytic laser techniques for treating vocal fold lesions motivated the development of a model for research and surgical training. The chick chorioallantoic membrane (CAM), which is composed of a microvasculature suspended within the egg albumen, simulates the vocal fold microcirculation within the superficial lamina propria (SLP). To characterize this model, we compared measurements of vessel diameters to superficial vessels in human vocal folds.
   Methods: The diameters of first-, second-, and third-order CAM vessels were measured in fertilized chicken eggs. The superficial blood vessels of the human vocal fold were measured from intraoperative images.
   Results: According to the branching pattern, vessel segments were identified as first-, second-, or third-order, with average diameters of 0.035 mm (0.02 to 0.1 mm), 0.18 mm (0.12 to 0.41 mm), and 0.8 mm (0.6 to 0.98 mm), respectively. The total vessels measured included 362 first-order, 119 second-order, and 82 third-order vessels. In 10 adult human vocal folds, an average vessel diameter of 0.04 mm (0.015 to 0.1 mm) was observed in 50 vessels.
   Conclusions: The CAM microvasculature suspended in albumen provides a useful surgical model simulating the microcirculation within the SLP of the human vocal fold. Although first-order CAM vessels best approximate the size of normal vocal fold subepithelial vessels seen at surgery, second- and third-order vessels resemble the vascular abnormalities frequently encountered during microsurgery for phonotraumatic lesions.
C1 [Broadhurst, Matthew S.; Kobler, James B.; Burns, James A.; Zeitels, Steven M.] Massachusetts Gen Hosp, Ctr Laryngeal Surg & Voice Rehab, Boston, MA 02114 USA.
   [Broadhurst, Matthew S.; Kobler, James B.; Burns, James A.; Zeitels, Steven M.] Massachusetts Gen Hosp, Harvard Med Sch, Dept Surg, Boston, MA 02114 USA.
   [Anderson, R. Rox] Massachusetts Gen Hosp, Dept Dermatol, Boston, MA 02114 USA.
RP Zeitels, SM (reprint author), Massachusetts Gen Hosp, Ctr Laryngeal Surg & Voice Rehab, Boston, MA 02114 USA.
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   ZEITELS SM, 2006, OFFICE BASED LASER L
   Zeitels SM, 2001, ATLAS PHONOMICROSURG
   Zeitels SM, 2006, OTOLARYNG CLIN N AM, V39, P159, DOI 10.1016/j.otc.2005.10.001
   Zeitels SM, 2006, ANN OTO RHINOL LARYN, V115, P571
   Zeitels SM, 2006, ANN OTO RHINOL LARYN, V115, P679
NR 15
TC 4
Z9 4
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD DEC
PY 2007
VL 116
IS 12
BP 917
EP 921
PG 5
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 243VI
UT WOS:000251825000010
PM 18217511
ER

PT J
AU Otto, BA
   Jacob, A
   Klein, MJ
   Welling, DB
AF Otto, Bradley A.
   Jacob, Abraham
   Klein, Michael J.
   Welling, D. Bradley
TI Chondromyxoid fibroma of the temporal bone: Case report and review of
   the literature
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE bone; bone tumor; chondromyxoid fibroma; mastoid; neoplasm; temporal
   bone
ID SKULL BASE; TUMOR
AB Objectives: We describe the clinical presentation, imaging, and pathology results of a patient with chondromyxoid fibroma (CMF) involving the mastoid portion of the temporal bone. The literature covering CMF of the head and neck is reviewed.
   Methods: The patient chart, including imaging and pathology results, was analyzed. An English-language literature review of skull base CMF was performed.
   Results: Eighty-seven cases of CMF involving the head and neck have been reported in the scientific literature. Sixty-two cases involved the skull base, temporal bone, nasal cavity, or paranasal sinuses. Including this patient, only 8 cases of CMF isolated to the temporal bone have been reported. Most patients experience insidious onset of symptoms such as hearing loss or headache. A computed tomographic scan best shows the relationship of the tumor to surrounding bone and may show intratumoral calcification. Surgical removal was the treatment most commonly used. Although irradiation has been used in selected cases, it is usually avoided because of the potential risk for malignant transformation.
   Conclusions: Chondromyxoid fibroma, a slow-growing bone tumor, is exceedingly rare within the mastoid. Its differential diagnosis includes chordoma, chondroid chordoma, and low-grade myxoid chondrosarcoma. Surgical excision is the treatment of choice.
C1 [Otto, Bradley A.; Jacob, Abraham; Welling, D. Bradley] Ohio State Univ, Dept Otolaryngol Head & Neck Surg, Columbus, OH 43210 USA.
   [Klein, Michael J.] Univ Alabama, Ctr Metab Bone Dis, Sch Med, Dept Pathol,Surg Pathol Sect, Birmingham, AL 35487 USA.
RP Jacob, A (reprint author), Ohio State Univ, Dept Otolaryngol Head & Neck Surg, 456 W 10th Ave,Suite 4A, Columbus, OH 43210 USA.
CR Baujat B, 2001, AM J OTOLARYNG, V22, P150, DOI 10.1053/ajot.2001.22582
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   Suzuki S, 1999, CLIN NEUROPATHOL, V18, P37
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NR 17
TC 8
Z9 9
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD DEC
PY 2007
VL 116
IS 12
BP 922
EP 927
PG 6
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 243VI
UT WOS:000251825000011
PM 18217512
ER

PT J
AU Hewitt, KM
   Sharma, PK
   Samowitz, W
   Hobbs, M
AF Hewitt, Kimberly M.
   Sharma, Pramod K.
   Samowitz, Wade
   Hobbs, Maurine
TI Aberrant methylation of the HRPT2 gene in parathyroid carcinoma
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE HRPT2 gene; methylation; parathyroid carcinoma
ID JAW TUMOR SYNDROME; FAMILIAL ISOLATED HYPERPARATHYROIDISM; HEREDITARY
   HYPERPARATHYROIDISM; DNA METHYLATION; PARAFIBROMIN; MUTATIONS; KINDREDS;
   CANCER
AB Objectives: The incidence of parathyroid carcinoma in hyperparathyroidism-jaw tumor syndrome (HPT-JT) is reported to be as hi-h as 15%. We used a methylation-specific polymerase chain reaction (MS-PCR) technique to investigate whether hypermethylation is one mechanism of HRPT2 gene inactivation in parathyroid tumors.
   Methods: DNA was extracted from samples of parathyroid tumors embedded in paraffin. MS-PCR was performed on 11 parathyroid carcinomas, 37 sporadic parathyroid adenomas from control subjects, and 6 parathyroid adenomas from 3 patients with HPT-JT. Methylated and unmethylated PCR products from 2 tumors (Nos. 2 and 6) were cloned. Clones containinc, inserts were sequenced.
   Results: Two of 11 (18%) parathyroid carcinomas showed amplification patterns consistent with methylation, compared to 0 of 37 sporadic parathyroid adenomas, and 1 of 6 (17%) parathyroid tumor samples from 3 HPT-JT patients. These results were confirmed by sequencing multiple clones from each of these samples.
   Conclusions: There is increasing evidence that loss of HRPT2 gene expression is strongly associated with parathyroid carcinomas. Our data indicate that methylation of the HRPT2 promoter may be another mechanism by which HRPT2 gene inactivation gives rise to parathyroid carcinomas.
C1 [Hewitt, Kimberly M.; Sharma, Pramod K.] Univ Utah, Dept Surg, Div Otolaryngol, Salt Lake City, UT 84132 USA.
   [Samowitz, Wade] Univ Utah, Dept Pathol, Salt Lake City, UT 84132 USA.
   [Hobbs, Maurine] Univ Utah, Dept Internal Med, Salt Lake City, UT 84132 USA.
RP Sharma, PK (reprint author), Univ Utah, Sch Med, Div Otolaryngol, 50 N Med Dr,3C-120, Salt Lake City, UT 84132 USA.
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NR 22
TC 19
Z9 19
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD DEC
PY 2007
VL 116
IS 12
BP 928
EP 933
PG 6
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 243VI
UT WOS:000251825000012
PM 18217513
ER

PT J
AU Johnston, N
   Wells, CW
   Blumin, JH
   Toohill, RJ
   Merati, AL
AF Johnston, Nikki
   Wells, Clive W.
   Blumin, Joel H.
   Toohill, Robert J.
   Merati, Albert L.
TI Receptor-mediated uptake of pepsin by laryngeal epithelial cells
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE laryngopharyngeal reflux; larynx; pepsin; receptor; reflux
ID LARYNGOPHARYNGEAL REFLUX DISEASE; IMPEDANCE; GASTROESOPHAGEAL;
   RELIABILITY; VALIDITY
AB Objectives: Previous data suggest a mechanistic link between exposure to pepsin and cellular changes that lead to laryngopharyngeal disorders. Initial confocal microscopy analysis of pepsin uptake by cultured hypopharyngeal epithelial cells revealed that pepsin may be taken up by a specific process. The objective of this study was to use electron microscopy to confirm the initial confocal findings and to determine whether uptake of pepsin by laryngeal epithelial cells is receptor-mediated.
   Methods: Cultured human hypopharyngeal FaDu cells and human laryngeal biopsy specimens, taken from the posterior larynx of "control" patients without symptoms or findings of laryngopharyngeal reflux, were exposed to purified human pepsin 3b with or without transferrin (a marker for receptor-mediated endocytosis) in vitro. Uptake of pepsin was documented by electron microscopy.
   Results: Pepsin co-localized with transferrin in intracellular vesicles; this finding confirms that pepsin is taken up by laryngeal epithelial cells by receptor-mediated endocytosis.
   Conclusions: This is a novel finding that further defines the role and mechanism of pepsin-mediated injury in laryngopharyngeal reflux. The objective of ongoing research is to identify the receptor and investigate potential antagonists as a new therapeutic option for patients with reflux-attributed disease - in particular, those patients who have persistent symptoms despite acid suppression therapy.
C1 [Johnston, Nikki; Blumin, Joel H.; Toohill, Robert J.; Merati, Albert L.] Med Coll Wisconsin, Dept Otolaryngol & Commun Sci, Milwaukee, WI 53226 USA.
   [Wells, Clive W.] Med Coll Wisconsin, Dept Microbiol & Mol Genet, Milwaukee, WI 53226 USA.
RP Johnston, N (reprint author), Med Coll Wisconsin, Dept Otolaryngol & Commun Sci, 9200 W Wisconsin Ave, Milwaukee, WI 53226 USA.
CR Belafsky PC, 2002, J VOICE, V16, P274, DOI 10.1016/S0892-1997(02)00097-8
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   Johnston N, 2007, LARYNGOSCOPE, V117, P1036, DOI 10.1097/M1LG.0b013e31804154c3
   Johnston N, 2006, ANN OTO RHINOL LARYN, V115, P47
   Johnston N, 2004, LARYNGOSCOPE, V114, P2129, DOI 10.1097/01.mlg.0000149445.07146.03
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   Mainie I, 2006, GUT, V55, P1398, DOI 10.1136/gut.2005.087668
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NR 13
TC 28
Z9 30
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD DEC
PY 2007
VL 116
IS 12
BP 934
EP 938
PG 5
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 243VI
UT WOS:000251825000013
PM 18217514
ER

PT J
AU Zirkle, M
   Taplin, MA
   Anthony, R
   Dubrowski, A
AF Zirkle, Molly
   Taplin, Michael A.
   Anthony, Richard
   Dubrowski, Adam
TI Objective assessment of temporal bone drilling skills
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE assessment; surgical education; technical skill; temporal bone
   laboratory
ID SURGICAL RESIDENTS; TECHNICAL SKILL; PERFORMANCE
AB Objectives: There is great interest in training surgeons in the technical aspects of their craft through simulation and laboratory-based exercises. However, there are as yet only a few objective tools to assess technical performance in a laboratory setting. This study assesses three potential objective assessment tools for a traditional otolaryngology laboratory exercise, temporal bone drilling.
   Methods: We performed a validation study in an academic training program. Nineteen otolaryngology residents performed a cortical mastoidectomy on a cadaveric temporal bone. The participants were divided into two groups, experienced and novice, based on previous temporal bone drilling experience. Performance was rated by two independent, blinded experts using four different assessments, the Global Rating Scale (GRS), the Task-Based Checklist (TBC), the final product analysis (FPA), and expert opinion (130).
   Results: The interrater reliability for all four assessments was good. Two potential objective assessments, the GRS and the TBC, and the traditional assessment tool of EO, correlated with trainee experience. The FPA, however, did not correlate with trainee experience. A logistic regression analysis of all assessments showed that the TBC correlates with EO.
   Conclusions: This study validates EO, the GRS, and the TBC as measures of temporal bone drilling performance. Of these measures, the TBC correlates best with EO according to logistic regression and can be reliably used as an objective assessment of temporal bone drilling.
C1 Univ Toronto, Wilson Ctr Res Clin Educ, Dept Otolaryngol Head & Neck Surg, Toronto, ON M5B 1W8, Canada.
   Univ Toronto, Mt Sinai Hosp, Surg Skills Lab, Toronto, ON, Canada.
RP Zirkle, M (reprint author), Univ Toronto, Wilson Ctr Res Clin Educ, Dept Otolaryngol Head & Neck Surg, 30 Bond St, Cardinal Carter Wing, Toronto, ON M5B 1W8, Canada.
CR Abraham T, 2006, AM SURGEON, V72, P35
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   Babineau TJ, 2004, ARCH SURG-CHICAGO, V139, P366, DOI 10.1001/archsurg.139.4.366
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NR 11
TC 18
Z9 18
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD NOV
PY 2007
VL 116
IS 11
BP 793
EP 798
PG 6
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 237DN
UT WOS:000251353400001
PM 18074662
ER

PT J
AU Hekiert, AM
   Mick, R
   Mirza, N
AF Hekiert, Adrianna M.
   Mick, Rosemarie
   Mirza, Natasha
TI Prediction of difficult laryngoscopy: Does obesity play a role?
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT 87th Annual Meeting of the American-Broncho-Esophagological-Association
CY APR 26-27, 2007
CL San Diego, CA
SP Amer Broncho Esophagol Assoc
DE difficult laryngeal exposure; obesity; predictor
ID TRACHEAL INTUBATION; LARYNGEAL EXPOSURE
AB Objectives: This study was intended to 1) identify preoperative predictors of difficult laryngoscopy and 2) determine the role of obesity in difficulty of obtaining adequate laryngeal exposure.
   Methods: A prospective study was undertaken of 63 patients who were undergoing elective direct laryngoscopy. Thirty-six patients met the obesity criteria (body mass index of at least 30 kg/m2). Measurements of height, weight, and neck circumference and Mallampati and Cormack-Lehane scores were obtained. The ease of laryngeal exposure was recorded by the attending surgeon on a visual analog scale (VAS; I to 10). Difficult laryngeal exposure (DLE) was defined as a VAS score of at least 3. The candidate morphological predictors were investigated.
   Results: Obesity and Mallampati wore were found to be predictors of DLE (p <.001). The VAS score was positively correlated with body mass index (p =.007), weight (p =.05), Mallampati score (p <.001), and Cormack-Lehane score (p <.001). Among obese patients, the VAS score was correlated with the Cormack-Lehane score (p =.01), whereas in nonobese patients the VAS score showed a significant association with both the Mallampati (p =.02) and Cormack-Lehane (p =.0 1) scores.
   Conclusions: Obese patients and those with a Mallampati score of at least 2 posed a significantly higher risk of DLE. Preoperative identification of a potentially difficult airway may aid surgical planning and allow more effective communication with a collaborating anesthesiologist.
C1 Univ Penn, Med Ctr, Dept Otolaryngol Head & Neck Surg, Philadelphia, PA 19104 USA.
   Univ Penn, Med Ctr, Ctr Clin Epidemiol & Biostat, Philadelphia, PA USA.
RP Mirza, N (reprint author), Univ Penn, Med Ctr, Dept Otolaryngol Head & Neck Surg, 3400 Spruce St, 5th Fl Ravdin Bldg, Philadelphia, PA 19104 USA.
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   Hsiung MW, 2004, LARYNGOSCOPE, V114, P358, DOI 10.1097/00005537-200402000-00033
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NR 13
TC 11
Z9 12
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD NOV
PY 2007
VL 116
IS 11
BP 799
EP 804
PG 6
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 237DN
UT WOS:000251353400002
PM 18074663
ER

PT J
AU Friedman, M
   Gurpinar, B
   Lin, HC
   Schalch, P
   Joseph, NJ
AF Friedman, Michael
   Gurpinar, Berk
   Lin, Hsin-Ching
   Schalch, Paid
   Joseph, Ninos J.
TI Impact of treatment of gastroesophageal reflux on obstructive sleep
   apnea-hypopnea syndrome
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT 87th Annual Meeting of the American-Broncho-Esophagological-Association
CY APR 26-27, 2007
CL San Diego, CA
SP Amer Broncho Esophagol Assoc
DE adjunctive treatment; gastroesophageal reflux; laryngopharyngeal reflux;
   obstructive sleep apnea-hypopnea syndrome; proton pump inhibitor therapy
ID POSITIVE AIRWAY PRESSURE; LARYNGOPHARYNGEAL REFLUX; DISEASE; EFFICACY;
   THERAPY; NECK; HEAD
AB Objectives: We test the hypothesis that treatment of gastroesophageal reflux disease (GERD) can improve obstructive sleep apnea-hypopnea syndrome (OSAHS).
   Methods: One hundred forty-six patients with OSAHS underwent a complete history-taking, physical examination, and laboratory testing, including questions related to GERD symptoms. Full-night attended polysomnography, 24-hour wireless pH study at the upper esophagus, snoring level evaluation, Epworth Sleepiness Scale, and quality-of-life surveys were completed for each patient. Patients who tested positive for GERD were treated with esomeprazole magnesium 40 mg once daily for 2 to 12 months. The 24-hour pH study was repeated, and those patients with elimination of GERD were reevaluated by polysomnography,snoring level evaluation, Epworth Sleepiness Scale, quality-of-life surveys, and subjective data collection.
   Results: Forty-one patients completed single-dose treatment with esomeprazole, but the repeat 24-hour pH study showed that 9 patients had persistent GERD. In the 29 patients who completed phase 2 with normal pH study findings, the snoring level decreased from 9.7 0.5 to 7.9 1.3 (p <.000 1), the Epworth Sleepiness Scale score decreased from 14.2 +/- 2.5 to 11.1 +/- 2.4 (p <.0001), the apnea-hypopnea index decreased from 37.9 +/- 19.1 to 28.8 +/- 11.5 (p =.006), and the minimum saturation of oxygen increased from 84.1 % +/- 7.8% to 86.9% +/- 5.0% (p =.055).
   Conclusions: Treatment of GERD had a significant impact on the reduction of the apnea-hypopnea index, snoring, and daytime sleepiness. Elimination of GERD should be part of a comprehensive treatment plan for patients with OSAHS.
C1 Rush Univ, Med Ctr, Dept Otolaryngol & Bronchoesophagol, Chicago, IL USA.
   Advocate Illinois Mason, Med Ctr, Adv Ctr Specialty Care, Dept Otolaryngol, Chicago, IL USA.
   Univ Calif Irvine, Med Ctr, Dept Otolaryngol, Irvine, CA USA.
RP Friedman, M (reprint author), 30 N Michigan Ave, Suite 1107, Chicago, IL 60602 USA.
RI Schalch, Paul/B-6278-2008
OI Schalch, Paul/0000-0003-4595-6850
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NR 27
TC 15
Z9 15
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD NOV
PY 2007
VL 116
IS 11
BP 805
EP 811
PG 7
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 237DN
UT WOS:000251353400003
PM 18074664
ER

PT J
AU Meinzen-Derr, J
   Wiley, S
   Creighton, J
   Choo, D
AF Meinzen-Derr, Jareen
   Wiley, Susan
   Creighton, Jodi
   Choo, Daniel
TI Auditory skills checklist: Clinical tool for monitoring functional
   auditory skill development in young children with cochlear implants
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE cochlear implant; functional auditory skill; young child
ID LANGUAGE-DEVELOPMENT; POPULATION; VALIDATION; SCALE
AB Objectives: The Auditory Skills Checklist (c) (ASC) was developed to address the need for tools to evaluate functional auditory skill progress in very young children with sensorineural hearing loss. We describe the development, validation, and utility of the ASC for use in young children with cochlear implants.
   Methods: Using the ASC, we measured auditory skills in 37 subjects who received cochlear implants at no more than 36 months of age. Repeated measures analysis was conducted to determine expected auditory skill development after implantation. Interrater reliability was tested on a small subset. The ASC was compared to the Infant-Toddler Meaningful Auditory Integration Scale (IT-MAIS) to determine its validity in measuring functional auditory skills.
   Results: The ASC had excellent internal consistency (Cronbach's alpha, 0.98) and interrater reliability (intraclass correlation coefficient, 0.99), and was highly correlated with the IT-MAIS (r = 0.90). According to the repeated measures analysis, children who received a cochlear implant at 36 months of age or earlier were expected to increase their ASC score by 8 points every 3 months (beta coefficient, 8.3; p <.001).
   Conclusions: The ASC is a clinically relevant and easily administered tool for assessing the functional auditory skills of young children with a cochlear implant. By assessing auditory skill development over time with the ASC, we can better realize expectations for a particular child based on his or her age, hearing loss level, and management strategies in place.
C1 Univ Cincinnati, Coll Med, Ctr Biostat & Epidemiol, Cincinnati, OH USA.
   Univ Cincinnati, Coll Med, Dept Pediat Otolaryngol, Hearing & Deafness Res Ctr, Cincinnati, OH USA.
   Univ Cincinnati, Coll Med, Div Dev & Behav Pediat, Cincinnati, OH USA.
   Univ Cincinnati, Coll Med, Div Audiol, Cincinnati, OH USA.
   Univ Cincinnati, Coll Med, Cincinnati Childrens Hosp, Med Ctr, Cincinnati, OH USA.
RP Meinzen-Derr, J (reprint author), Cincinnati Childrens Hosp, Med Ctr, Ctr Biostat & Epidemiol, Hearing & Deafness Res Ctr, 3333 Burnet Ave, MLC 5041, Cincinnati, OH 45229 USA.
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NR 16
TC 6
Z9 7
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD NOV
PY 2007
VL 116
IS 11
BP 812
EP 818
PG 7
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 237DN
UT WOS:000251353400004
PM 18074665
ER

PT J
AU Torgerson, CS
   Brydes, R
   Chen, JM
   Dubrowski, A
AF Torgerson, Cory S.
   Brydes, Ryan
   Chen, Joseph M.
   Dubrowski, Adam
TI Drilling simulated temporal bones with left-handed tools: A
   left-hander's right?
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT 108th Annual Meeting of the Triological-Society
CY MAY 12-16, 2005
CL Boca Raton, FL
SP Triol Soc
DE laterality; measurement validation; motor learning; surgical education;
   surgical skills training
ID OBJECTIVE STRUCTURED ASSESSMENT; TECHNICAL SKILL; SURGICAL RESIDENTS;
   PERFORMANCE; PREFERENCE; MODEL
AB Objectives: Left-handed trainees can be at a disadvantage in the surgical environment because of a right-handed bias. The effectiveness of teaching left-handed trainees to use an otologic drill designed for their dominant hand versus the conventional right-handed drill was examined.
   Methods: Novice medical students were recruited from the university community. Twenty-four subjects were left-handed, and 12 were right-handed. Eight left-handed surgeons also participated. A randomized controlled trial was conducted to compare the performance of left-handed trainees using novel left-handed drills to that of left-handed trainees using right-handed tools and to that of right-handed trainees using right-handed tools. The evaluation consisted of 3 phases: pretest, skill acquisition, and 2 post-tests.-The measurement tools included expert assessment of performance, and subjective and objective final product analyses.
   Results: An initial construct validity phase was conducted in which validity of the assessment tools was ensured. Both the left-handers using left-handed tools and the right-handers using right-handed tools significantly outperformed the left-handers using right-handed tools at pretest, immediate posttest, and delayed posttest. All participants improved their performance as a function of practice.
   Conclusions: The left-handed trainees learned bone drilling better with tools designed for the left hand. These tools may be incorporated into residency training programs for the development of surgical technical skills. Future studies should assess skill transfer between the left-handed and right-handed drills.
C1 Univ Toronto, Wilton Ctr Res Educ, Toronto, ON M5G 2C4, Canada.
   Univ Toronto, Sunny & Womens Coll, Hlth Sci Ctr, Dept Otolaryngol, Toronto, ON, Canada.
   Univ Toronto, Mt Sinai Hosp, Surg Skills Ctr, Dept Surg, Toronto, ON, Canada.
RP Dubrowski, A (reprint author), Univ Toronto, Wilton Ctr Res Educ, Eaton S I-542, 200 Elizabet St, Toronto, ON M5G 2C4, Canada.
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NR 23
TC 3
Z9 3
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD NOV
PY 2007
VL 116
IS 11
BP 819
EP 826
PG 8
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 237DN
UT WOS:000251353400005
PM 18074666
ER

PT J
AU Sirikci, A
   Karatas, E
   Durucu, C
   Baglam, T
   Bayazit, Y
   Ozkur, A
   Sonmezisik, S
   Kanlikama, M
AF Sirikci, Akif
   Karatas, Erkan
   Durucu, Cengiz
   Baglam, Tekin
   Bayazit, Yildirim
   Ozkur, Ayhan
   Sonmezisik, Serdar
   Kanlikama, Muzaffer
TI Noninvasive assessment of benign lesions of vocal folds by means of
   ultrasonography
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE benign lesion; diagnosis; larynx; ultrasonography
ID HIGH-FREQUENCY ULTRASOUND; CHILDREN; INFANTS
AB Objectives: Although ultrasonography (US) has been widely used in various parts of the body, its application in laryngeal examination has been limited. Our objective was to evaluate the significance of US examination in benign lesions of the vocal folds.
   Methods: Ultrasonographic examination of the vocal folds was performed in 14 patients in whom benign lesions of the vocal folds had been diagnosed by videolaryngoscopy and microlaryngoscopy. Microlaryngoscopic surgery was performed after US examination. Each lesion was analyzed for the following US features: shape, size, and echotexture (echogenicity and homogeneity).
   Results: In total, 16 lesions were diagnosed in 14 patients by means of videolaryngoscopy and microlaryngoscopy. Ultrasonographic examination was capable of diagnosing 14 of the 16 lesions (87.25%). Ultrasonography mainly helped in the diagnosis of sessile polyps, nodules, and leukoplakia that were larger than 2 mm. The lesions were linear hyperechoic, heterogeneous hyperechoic, hypoechoic, and isoechoic if they were leukoplakia, nodules, hemorrhagic polyps, and other polypoid lesions, respectively. The results are better if the diagnosis follows the corresponding US echotexture pattern rather than videolaryngoscopy and microlaryngoscopy.
   Conclusions: Laryngeal US examination appears to be a useful diagnostic tool for supplementing microlaryngoscopy in the assessment of benign lesions of vocal folds. In contrast to these currently used imaging techniques, anesthesia is not necessary in laryngeal US examination. In addition, US is noninvasive, painless, and much less expensive than the other techniques.
C1 Gaziantep Univ, Fac Med, Dept Radiol, Gaziantep, Turkey.
   Gaziantep Univ, Fac Med, Dept Otolaryngol Head & Neck Surg, Gaziantep, Turkey.
   Gazi Univ, Fac Med, Dept Otolaryngol Head & Neck Surg, Ankara, Turkey.
RP Karatas, E (reprint author), Gaziantep Univ, Fac Med, Sahinbey Med Ctr, Dept Otolaryngol Head & Neck Surg, TR-27310 Gaziantep, Turkey.
CR Arens C, 1999, EUR ARCH OTO-RHINO-L, V256, P316, DOI 10.1007/s004050050254
   Arens C, 1998, EUR ARCH OTO-RHINO-L, V255, P250, DOI 10.1007/s004050050052
   Friedman EM, 1997, ANN OTO RHINOL LARYN, V106, P199
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   Sidhu S, 2001, ANZ J SURG, V71, P737, DOI 10.1046/j.1445-1433.2001.02257.x
   Tamura E, 2001, LARYNGOSCOPE, V111, P1767, DOI 10.1097/00005537-200110000-00019
   Vats A, 2004, J LARYNGOL OTOL, V118, P429
NR 8
TC 8
Z9 11
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD NOV
PY 2007
VL 116
IS 11
BP 827
EP 831
PG 5
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 237DN
UT WOS:000251353400006
PM 18074667
ER

PT J
AU Hartl, DM
   De Mones, E
   Hans, S
   Janot, F
   Brasnu, D
AF Hartl, Dana M.
   De Mones, Erwan
   Hans, Stephane
   Janot, Francois
   Brasnu, Daniel
TI Treatment of early-stage glottic cancer by transoral laser resection
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT Meeting of the American-Laryngological-Association
CY APR 26-27, 2007
CL San Diego, CA
SP Amer Laryngol Assoc
DE minimally invasive surgery; larynx; laser; squamous cell carcinoma
ID PARTIAL LARYNGECTOMY; ANTERIOR COMMISSURE; CARCINOMA; SURGERY;
   CORDECTOMY; LARYNX; T1; MICRORESECTION; RECURRENCES; MANAGEMENT
AB Objectives: We reviewed outcomes of treatment of early glottic carcinoma by transoral laser resection.
   Methods: We performed a retrospective study of tumor stage, type of cordectomy (European Laryngological Society), resection margins, local control, and laryngeal preservation.
   Results: Of 142 patients treated with curative intent, 79 (92% male; average age, 63 years) were retained for this study, on the basis of availability of information regarding resection margins, the absence of adjuvant radiotherapy, and follow-up of at least 2 years. The tumors were classified pTis (n = 21), pT1a (n = 5 1), or pT1b (n = 7) and were treated by cordectomy types 1 (23%),II (30%),III (27%), IV (6%), and V (14%). The average follow-up was 56 months (range, 24 to 150 months). The overall 5-year actuarial recurrence-free survival rate was 89%, and the 5-year actuarial disease- specific survival rate was 97.3%. There were 11 local recurrences (14%); 7 were treated by another laser resection, 1 by radiotherapy, 1 by supracricoid partial laryngectomy, and 2 by total laryngectomy. The overall rate of final local control with the laser alone was 100% for patients with initially positive margins, 95% for those with initially suspicious margins, and 94% for those with free margins. The overall rate of organ preservation was 100% for patients with positive or suspicious margins and 96% for those with free margins. Margin status (p =.39), cordectomy type (p =.67), and anterior commissure involvement (p =.16) were not statistically related to recurrence (Kaplan-Meier calculations with nonparametric univariate analysis). The recurrence rate was significantly higher for T1b tumors, however (p =.001).
   Conclusions: Laser microresection provides high rates of local control and organ preservation for early glottic cancer. Positive or suspicious margins were not related to recurrence, nor was anterior commissure involvement. This study implies that suspicious margins can be managed with a "watch- and-wait" attitude. Re-treatment with laser, external partial laryngectomy, and radiotherapy remain therapeutic options for recurrences.
C1 Inst Gustave Roussy, Dept Otolaryngol Head & Neck Surg, F-94805 Villejuif, France.
   Univ Paris 05, APHP Hop Europeen Georges Pumpidou, Dept Otolaryngol Head & Neck Surg, Voice Biomat & Head & Neck Oncol Res Lab, Paris, France.
RP Hartl, DM (reprint author), Inst Gustave Roussy, Dept Otolaryngol Head & Neck Surg, 39, Rue Camille Desmoulins, F-94805 Villejuif, France.
CR Bron LP, 2001, HEAD NECK-J SCI SPEC, V23, P823, DOI 10.1002/hed.1120
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NR 19
TC 30
Z9 33
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD NOV
PY 2007
VL 116
IS 11
BP 832
EP 836
PG 5
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 237DN
UT WOS:000251353400007
PM 18074668
ER

PT J
AU Bleier, BS
   Levine, MS
   Mick, R
   Rubesin, SE
   Sack, SZ
   McKinney, K
   Mirza, N
AF Bleier, Benjamin S.
   Levine, Marc S.
   Mick, Rosemarie
   Rubesin, Stephen E.
   Sack, Stephen Z.
   McKinney, Kibwei
   Mirza, Natasha
TI Dysphagia after chemoradiation: Analysis by modified barium swallow
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT 110th Annual Meeting of the
   American-Academy-of-Otolaryngology-Head-and-Neck-Surgery-Foundation
CY SEP 17-20, 2006
CL Toronto, CANADA
SP Amer Acad Otolaryngol Head & Neck Surg Fdn
DE dysphagia; head and neck cancer; modified barium swallow study;
   radiotherapy
ID NECK-CANCER; ADVANCED HEAD; CHEMOTHERAPY; RADIATION
AB Objectives: We sought to describe the findings of modified barium swallow study after chemoradiation in patients with head and neck cancer and to correlate these findings with clinical variables, including gastrostomy tube dependence and clinical pneumonia.
   Methods: We retrospectively reviewed 49 patients at a tertiary care center who underwent modified barium swallow study for dysphagia after chemoradiation.
   Results: Patients with nonlaryngeal lesions had increased cricopharyngeal impairment (27.8% versus 0.0%; p =.04). Patients who underwent concomitant chemotherapy had increased epiglottic changes relative to those who had radiotherapy alone (66.7% versus 30.8%; p =.05). Clinical pneumonia developed in 31.9% of the patients, and 79.6% required gastrostomy tube placement for a mean duration of 18.1 months.
   Conclusions: Chemoradiation effects deglutition at multiple levels. A large percentage of patients will develop pneumonia and feeding tube dependence. This study is among the largest to correlate the results of modified barium swallow studies to clinical variables in this patient population. This study highlights the significant incidence of gastrostomy tube dependence and pneumonia in these patients.
C1 Univ Penn, Dept Otorhinolaryngol Head & Neck Surg, Philadelphia, PA 19104 USA.
   Univ Penn, Dept Radiol, Div Gastrointestinal Radiol, Philadelphia, PA 19104 USA.
   Univ Penn, Dept Biostat & Epidemiol, Philadelphia, PA 19104 USA.
   Univ Penn, Dept Radiat Oncol, Philadelphia, PA 19104 USA.
RP Bleier, BS (reprint author), UPHS, Dept Otorhinolaryngol Head & Neck Surg, 3400 Spruce St, 5 Ravdin, Philadelphia, PA 19104 USA.
CR Buntzel J, 2002, SEMIN RADIAT ONCOL, V12, P4, DOI 10.1053/srao.2002.31356
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   Logemann JA, 2006, HEAD NECK-J SCI SPEC, V28, P64, DOI 10.1002/hed.20299
   Nguyen NP, 2004, ANN ONCOL, V15, P383, DOI 10.1093/annonc/mdh101
   Pauloski BR, 2000, HEAD NECK-J SCI SPEC, V22, P474, DOI 10.1002/1097-0347(200008)22:5<474::AID-HED6>3.0.CO;2-I
   Pauloski BR, 1998, OTOLARYNG HEAD NECK, V118, P616, DOI 10.1177/019459989811800509
   Shiley SG, 2006, OTOLARYNG HEAD NECK, V134, P455, DOI 10.1016/j.otohns.2005.10.054
   Stenson KM, 2000, ARCH OTOLARYNGOL, V126, P371
   WOLF GT, 1991, NEW ENGL J MED, V324, P1685
NR 9
TC 18
Z9 18
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD NOV
PY 2007
VL 116
IS 11
BP 837
EP 841
PG 5
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 237DN
UT WOS:000251353400008
PM 18074669
ER

PT J
AU Suzuki, M
   Saigusa, H
   Chiba, S
   Hoshino, T
   Okamoto, M
AF Suzuki, Masaaki
   Saigusa, Hanako
   Chiba, Shintaro
   Hoshino, Tadahiko
   Okamoto, Makito
TI Prevalence of upper airway tumors and cysts among patients who snore
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE cyst; prevalence; sleep-disordered breathing; snore; tumor; upper airway
ID OBSTRUCTIVE SLEEP-APNEA; HEART HEALTH; ALLERGIC RHINITIS; NECK-CANCER
AB Objectives: Sleep specialists usually do not pay much attention to the upper airway in patients who snore, because they can make the diagnosis of sleep-disordered breathing without performing nasopharyngeal endoscopy if they have the Ep-worth Sleepiness Scale scores and the results of Polysomnography. The purpose of this study was to determine the prevalence of benign and malignant tumors and cysts in the upper airway in patients who snore.
   Methods: A retrospective multicenter trial was performed in 4 sleep laboratories. Adult male and female patients whose chief complaint on their first visit was witnessed snoring were enrolled in this study. All of the patients were evaluated by otolaryngologists using nasopharyngeal endoscopy to detect organic diseases in the upper airway.
   Results: Among 2,923 patients, 2 patients had malignant tumors, 5 had benign tumors, and 2 had cysts in the upper airway. The prevalence of upper airway benign and malignant tumors and cysts among adult male and female patients was 0.24%.
   Conclusions: Routine detailed nasopharyngeal endoscopy should be carried out in each institution so as not to overlook organic diseases in the upper airway among patients who snore.
C1 Teikyo Univ, Sch Med, Dept Otolaryngol, Tokyo 173, Japan.
   Ota Gen Hosp, Ota Mem Sleep Ctr, Tokyo, Japan.
   Hoshino ENT Ckin, Sleep Disordered Breathing Ctr, Tokyo, Japan.
   Kitasato Univ, Sch Med, Dept Otolaryngol, Tokyo, Japan.
RP Suzuki, M (reprint author), Teikyo Univ, Sch Med, Dept Otolaryngol, Itabashi Ku, 2-11-1 Kaga, Tokyo 1738605, Japan.
CR Bassetti C, 1999, SLEEP, V22, P217
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   Canova CR, 2004, RESPIRATION, V71, P138, DOI 10.1159/000076674
   Friedman M, 2001, LARYNGOSCOPE, V111, P1917, DOI 10.1097/00005537-200111000-00008
   Gami AS, 2005, NEW ENGL J MED, V352, P1206, DOI 10.1056/NEJMoa041832
   Kramer MF, 2001, ACTA OTO-LARYNGOL, V121, P494, DOI 10.1080/000164801300366651
   Kuna S, 2000, PRINCIPLES PRACTICE, P840
   Lee K, 2004, SLEEP MED REV, V8, P199, DOI 10.1016/j.smrv.2003.10.001
   Payne RJ, 2005, J OTOLARYNGOL, V34, P304, DOI 10.2310/7070.2005.34502
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NR 14
TC 1
Z9 1
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD NOV
PY 2007
VL 116
IS 11
BP 842
EP 846
PG 5
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 237DN
UT WOS:000251353400009
PM 18074670
ER

PT J
AU Yamashita, M
   Hirano, S
   Kanemaru, SI
   Tsuji, S
   Suehiro, A
   Ito, J
AF Yamashita, Masaru
   Hirano, Shigeru
   Kanemaru, Shin-Ichi
   Tsuji, Shunichiro
   Suehiro, Atsushi
   Ito, Juichi
TI Side population cells in the human vocal fold
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT Meeting of the American-Laryngological-Association
CY APR 26-27, 2007
CL San Diego, CA
SP Amer Laryngol Assoc
DE ABCG2; adenosine triphosphate binding cassette family; fluorescence;
   activated cell sorter; side population cell; vocal fold
ID BINDING CASSETTE TRANSPORTER; STEM-CELLS; FUNCTIONAL-PROPERTIES;
   PROGENITOR CELLS; SELF-RENEWAL; NEURAL STEM; BONE-MARROW; ADULT HUMAN;
   IN-VIVO; REGENERATION
AB Objectives: The regenerative processes of the vocal fold, or the existence of stem cells in the folds, are unknown. Side population (SP) cells are defined as cells that have the ability to exclude the DNA binding dye, Hoechst 33342. They are regarded as a cell population enriched with stem cells and can be isolated from non-SP cells by a fluorescence-activated cell sorter. This study was designed to determine whether SP cells exist in the human vocal fold, as a first step in elucidating the regenerative mechanisms of the vocal fold.
   Methods: Seven human excised larynges were used in this study. Two were used for fluuorescence- activated cell sorter analysis, and 5 were subjected to immunohistochemical analysis with antibodies against an adenosine triphosphate binding cassette transporter family member, ABCG2, which is expressed in SP cells.
   Results: The number of SP cells in the human vocal fold was about 0.2% of the total number of cells. ABCG2-positive cells were identified in both the epithelium and subepithelial tissue throughout the entire vocal fold.
   Conclusions: This preliminary study demonstrated the existence of SP cells in the human vocal fold. Further studies are warranted to clarify how these cells work in the vocal fold, particularly in the regenerative process.
C1 Univ Wisconsin, Dept Surg, Div Otolaryngol Head & Neck Surg, Madison, WI USA.
   Kyoto Univ, Grad Sch Med, Dept Otolaryngol Head & Neck Surg, Kyoto, Japan.
   Shiga Univ Med Sci, Dept Obstet & Gynecol, Shiga, Japan.
RP Yamashita, M (reprint author), Univ Wisconsin, Ctr Clin Sci, Dept Surg, Div Otolaryngol Head & Neck Surg, K4-723 600 Highland Ave, Madison, WI 53792 USA.
RI Yamashita, Masaru/B-2411-2009
CR Alvi Azra J, 2003, Breast Cancer Res, V5, pR1, DOI 10.1186/bcr563
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NR 30
TC 12
Z9 12
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD NOV
PY 2007
VL 116
IS 11
BP 847
EP 852
PG 6
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 237DN
UT WOS:000251353400010
PM 18074671
ER

PT J
AU Burns, JA
   Kobler, JB
   Heaton, JT
   Lopez-Guerra, G
   Anderson, RR
   Zeitels, SM
AF Burns, James A.
   Kobler, James B.
   Heaton, James T.
   Lopez-Guerra, Gerardo
   Anderson, R. Rox
   Zeitels, Steven M.
TI Thermal damage during thulium laser dissection of laryngeal soft tissue
   is reduced with air cooling: Ex vivo calf model study
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT 87th Annual Meeting of the American-Broncho-Esophagological-Association
CY APR 26-27, 2007
CL San Diego, CA
SP Amer Broncho Esophagol Assoc
DE cooling; dysphonia; hoarseness; laryngoscopy; laser cutting; thulium
   laser
ID CLINICAL EXPERIENCE; SURGERY; CANCER; CO2-LASER; MANAGEMENT; LESIONS;
   FIBER
AB Objectives: The 2-mu m-wavelength thulium laser has recently been shown to be an effective cutting instrument in endolaryngeal surgery, although there is increased thermal trauma as compared with the carbon dioxide laser. This study investigated temperature changes and thermal trauma during thulium laser dissection of laryngeal tissue, with and without air cooling, in an ex vivo model.
   Methods: A continuous-wave thulium laser (400-mu m fiber, 4-W continuous power, 4-second duration) was used to incise 10 calf vocal folds. Paired cooled and uncooled cuts were made in each fold with a dermatologic cooling device. A thermistor inserted into the glottic subepithelium was used to measure tissue temperatures. Thermal damage was analyzed histologically by measuring the depth of the zone of lactate dehydrogenase inactivation surrounding the mucosal incision.
   Results: The initial vocal fold temperature averaged 24.3 degrees C without cooling and 4.4 degrees C with cooling. The peak temperature during cutting averaged 59.1 degrees C without cooling and 28.0 degrees C with cooling. The thermal damage zone surrounding the cooled incisions was approximately 27% less than that surrounding the uncooled incisions.
   Conclusions: Air cooling can reduce the extent of thermal trauma associated with thulium laser surgery of the vocal folds, and the high-temperature plume. generated during laser cutting is effectively cleared.
C1 Massachusetts Gen Hosp, Ctr Laryngeal Surg & Voice Rehabil, Boston, MA 02114 USA.
   Harvard Univ, Sch Med, Dept Surg, Cambridge, MA 02138 USA.
   Harvard Univ, Sch Med, Dept Dermatol, Cambridge, MA 02138 USA.
   Massachusetts Gen Hosp, Wellman Ctr Photomed, Boston, MA 02114 USA.
RP Burns, JA (reprint author), Massachusetts Gen Hosp, Ctr Laryngeal Surg & Voice Rehabil, 1 Bowdoin Square, 11th Floor, Boston, MA 02114 USA.
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NR 22
TC 15
Z9 15
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD NOV
PY 2007
VL 116
IS 11
BP 853
EP 857
PG 5
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 237DN
UT WOS:000251353400011
PM 18074672
ER

PT J
AU Roy, N
   Stemple, J
   Merrill, RM
   Thomas, L
AF Roy, Nelson
   Stemple, Joseph
   Merrill, Ray M.
   Thomas, Lisa
TI Dysphagia in the elderly: Preliminary evidence of prevalence, risk
   factors, and socioemotional effects
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE prevalence; quality of life; risk; swallowing disorder
ID VOICE DISORDERS; GENERAL-POPULATION; GASTROESOPHAGEAL-REFLUX;
   RHEUMATOID-ARTHRITIS; SWALLOWING DISORDERS; IMPACT; QUESTIONNAIRE;
   TEACHERS
AB Objectives: Epidemiological studies of dysphagia in the elderly are rare. A non-treatment- seeking, elderly cohort was surveyed to provide preliminary evidence regarding the prevalence, risks, and socioemotional effects of swallowing disorders.
   Methods: Using a prospective, cross-sectional survey design, we interviewed 117 seniors living independently in Utah and Kentucky (39 men and 78 women; mean age, 76.1 years; SD, 8.5 years; range, 65 to 94 years) regarding 4 primary areas related to swallowing disorders: lifetime and current prevalence, symptoms and signs, risk and protective factors, and socioemotional consequences.
   Results: The lifetime prevalence of a swallowing disorder was 38%, and 33% of the participants reported a current problem. Most seniors with dysphagia described a sudden onset with chronic problems that had persisted for at least 4 weeks. Stepwise logistic regression identified 3 primary symptoms uniquely associated with a history of swallowing disorders: taking a longer time to eat (odds ratio [OR], 9.5; 95% confidence interval [CI], 2.3 to 40.2); coughing, throat clearing, or choking before, during, or after eating (OR, 3.4; 95 % CI, 1. 1 to 10.2); and a sensation of food stuck in the throat (OR, 5.2; 95% CL 1.8 to 10.0). Stroke (p =.02), esophageal reflux (p =.003), chronic obstructive pulmonary disease (p =.05), and chronic pain (p =.03) were medical conditions associated with a history of dysphagia. Furthermore, dysphagia produced numerous adverse socioemotional effects.
   Conclusions: This study provides preliminary evidence to suggest that chronic swallowing disorders are common among the elderly, and highlights the need for larger epidemiological studies of these disorders.
C1 Univ Utah, Dept Commun Sci & Disorders, Salt Lake City, UT 84112 USA.
   Brigham Young Univ, Dept Hlth Sci, Provo, UT 84602 USA.
   Univ Kentucky, Dept Rehabil Sci, Lexington, KY USA.
RP Roy, N (reprint author), Univ Utah, Dept Commun Sci & Disorders, 390 S 1530 E, Rm 1219, Salt Lake City, UT 84112 USA.
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NR 29
TC 53
Z9 59
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD NOV
PY 2007
VL 116
IS 11
BP 858
EP 865
PG 8
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 237DN
UT WOS:000251353400012
PM 18074673
ER

PT J
AU Berke, GS
   Neubauer, J
   Berry, DA
   Ye, M
   Chhetri, DK
AF Berke, Gerald S.
   Neubauer, Juergen
   Berry, David A.
   Ye, Ming
   Chhetri, Dinesh K.
TI Ex vivo perfused larynx model of phonation: Preliminary study
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT Meeting of the American-Laryngological-Association
CY APR 26-27, 2007
CL San Diego, CA
SP Amer Laryngol Assoc
DE ex vivo model; larynx; perfusion; physiology
AB Objectives: Although excised laryngeal models and physical models of the larynx are important in the study of laryngeal dynamics, they cannot be used to study the influence of neuromuscular contraction on vocal fold vibration, especially with regard to the thyroarytenoid muscle. Our aim was to develop an ex vivo larynx model of phonation, and combine the benefits of the in vivo and excised laryngeal models to the ex vivo situation.
   Methods: Three canine larynges were surgically removed and perfused ex vivo with modified Krebs-Henseleit reperfusion solution. The laryngeal nerves were stimulated, and an assessment of neuromuscular viability, phonation, and vocal fold vibration was made.
   Results: Neuromuscular stimulation, phonation, and experimental manipulation were possible for several hours after the onset of ex vivo perfusion. Repeatable periodic phonation in short bursts was achieved. Perfusion appears critical to maintain ex vivo viability, as adductory force was almost immediately lost upon cessation of ex vivo perfusion.
   Conclusions: The ex vivo larynx model has the potential to facilitate the measurement of glottal variables in a neuro-muscularly correct model. We propose that the further development of this laryngeal model may be useful in the study of laryngeal dynamics, particularly when invasive measurements, such as that of glottal exit flow, are required.
C1 Univ Calif Los Angeles, David Geffen Sch Med, Div Head & Neck Surg, Laryngeal Physiol & Dynam Lab, Los Angeles, CA USA.
RP Chhetri, DK (reprint author), Univ Calif Los Angeles, David Geffen Sch Med, Div Head & Neck Surg, 62-132 CHS, 10833 Le Conte Ave, Los Angeles, CA 90095 USA.
CR BERKE GS, 1987, LARYNGOSCOPE, V97, P871
   Chhetri DK, 2004, OTOLARYNG HEAD NECK, V131, P864, DOI 10.1016/j.otohns.2004.07.010
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NR 3
TC 3
Z9 3
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD NOV
PY 2007
VL 116
IS 11
BP 866
EP 870
PG 5
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 237DN
UT WOS:000251353400013
PM 18074674
ER

PT J
AU Daniilidou, P
   Carding, P
   Wilson, J
   Drinnan, M
   Deary, V
AF Daniilidou, Paressa
   Carding, Paul
   Wilson, Janet
   Drinnan, Michael
   Deary, Vincent
TI Cognitive Behavioral therapy for functional dysphonia: A pilot study
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT 110th Annual Meeting of the
   American-Academy-of-Otolaryngology-Head-and-Neck-Surgery-Foundation
CY SEP 17-20, 2006
CL Toronto, CANADA
SP Amer Acad Otolaryngol Head & Neck Surg Fdn
DE cognitive behavioral therapy; functional dysphonia; medically
   unexplained symptoms; voice therapy
ID UNEXPLAINED PHYSICAL SYMPTOMS; IRRITABLE-BOWEL-SYNDROME; VOICE THERAPY;
   SOMATOFORM DISORDERS; HOSPITAL ANXIETY; DEPRESSION SCALE; PRIMARY-CARE;
   PERSONALITY; PATHOLOGY; VALIDITY
AB Objectives: We sought to investigate whether a brief period of training in cognitive behavioral therapy (CBT) can improve the treatment of functional dysphonia by a speech and language therapist and ameliorate the psychological distress associated with this condition.
   Methods: In a consecutive cohort design, a speech and language therapist treated a small cohort (n = 15) of dysphonic patients with voice therapy alone. After a brief period of CBT training, she treated the next cohort of dysphonic patients (n = 13) with CBT enhanced voice therapy. Pretreatment and posttreatment measures were taken of voice quality and voice-related quality of life. The General Health Questionnaire 28 and the Hospital Anxiety and Depression Scale were used to assess psychological distress and general well-being.
   Results: All voice measures improved significantly in both cohorts. Both groups improved significantly on the General Health Questionnaire 28, with the CBT group improving significantly more than the control group. Only the CBT group improved significantly on the Hospital Anxiety and Depression Scale (depression subscale).
   Conclusions: Despite limitations of size, design, and between-group baseline differences, the results support the hypothesis that the addition of CBT skills to existing voice therapy is both feasible and clinically effective in the treatment of functional dysphonia.
C1 Univ Newcastle, Inst Hlth & Soc, Newcastle Upon Tyne NE2 4AA, Tyne & Wear, England.
   Univ Newcastle, Freeman Hosp, Dept Otolaryngol, Newcastle Upon Tyne NE2 4AA, Tyne & Wear, England.
   Univ Newcastle, Freeman Hosp, Dept Reg Med Phys, Newcastle Upon Tyne NE2 4AA, Tyne & Wear, England.
RP Deary, V (reprint author), Univ Newcastle, Inst Hlth & Soc, 21 Claremont Pl, Newcastle Upon Tyne NE2 4AA, Tyne & Wear, England.
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NR 31
TC 11
Z9 12
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD OCT
PY 2007
VL 116
IS 10
BP 717
EP 722
PG 6
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 221OC
UT WOS:000250236200002
PM 17987776
ER

PT J
AU Dubey, SP
   Molumi, CP
AF Dubey, Siba P.
   Molumi, Charles P.
TI Critical look at the surgical approaches of nasopharyngeal angiofibroma
   excision and "Total maxillary swing" as a possible alternative
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE angiofibroma; juvenile angiofibroma; lateral rhinotomy; midfacial
   degloving; nasopharynx; total maxillary swing; transpalatal approach
ID FORT-I OSTEOTOMY; JUVENILE ANGIOFIBROMA; RESECTION; EXPERIENCE;
   MANAGEMENT; UPDATE
AB Objectives: We critically analyzed different surgical approaches used for the excision of nasopharyngeal angiofibroma (NPA) at our hospital in a 10-year period and proposed "total maxillary swing" as a possible alternative approach.
   Methods: Retrospective review of the clinical and operative records was done regarding 39 cases of NPA that were surgically managed from 1995 to 2005. The duration of the surgical procedures, amount of blood loss and transfusion, time to recurrence, frequency of recurrence, functional and cosmetic deformity, and complications of all surgical procedures were thoroughly analyzed. These parameters were compared with total maxillary swing, a new approach recently being used by us, for the one-time excision of NPA.
   Results: A total of 61 operations including revision surgeries for recurrences were done in the 39 cases of NPA. Conventional surgical approaches were performed in 37 cases, and the total maxillary swing approach was used in 2 cases. This new approach provided a wider surgical exposure for complete tumor resection and better hemostasis without any recurrence or major functional deformity, which were seen with some of the conventional approaches.
   Conclusions: We found total maxillary swing to be a relatively safe alternate approach for the resection of NPA. We removed the entire tumors in a wider surgical field under the microscope with reduced blood loss and minimal complications or chance of recurrences.
C1 Univ Papua New Guinea, Sch Med & Hlth Sci, Port Moresby Gen Hosp, Dept Ear Nose & Throat, Boroko, Papua N Guinea.
   Univ Papua New Guinea, Sch Med & Hlth Sci, Div Clin Sci, Dept Otolaryngol, Boroko, Papua N Guinea.
RP Dubey, SP (reprint author), MS,POB 3265,Natl Capital Dist, Boroko, Papua N Guinea.
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NR 27
TC 3
Z9 3
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD OCT
PY 2007
VL 116
IS 10
BP 723
EP 730
PG 8
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 221OC
UT WOS:000250236200003
PM 17987777
ER

PT J
AU Li, PMMC
   Somdas, MA
   Eddington, DK
   Nadol, JB
AF Li, Peter M. M. C.
   Somdas, Mehmet A.
   Eddington, Donald K.
   Nadol, Joseph B., Jr.
TI Analysis of intracochlear new bone and fibrous tissue formation in human
   subjects with cochlear implants
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE bone; cochlear implant; computer-assisted three-dimensional imaging;
   fibrous tissue; histopathology
ID LABYRINTHITIS OSSIFICANS; INSERTION TRAUMA; TEMPORAL BONE; ELECTRODES;
   HEARING; HISTOPATHOLOGY; PRESERVATION; PERFORMANCE; POSITION
AB Objectives: In this study we aimed to evaluate new bone and new fibrous tissue formation in the inner ear following cochlear implantation.
   Methods: Twelve temporal bones from patients who underwent cochlear implantation during life were prepared for histologic study. The specimens were reconstructed by both 2-dimensional and 3-dimensional methods. These reconstructions were used to calculate the total volume and distribution of new bone and new fibrous tissue in the cochlea, the number of spiral ganglion cells, and other histopathologic parameters. Clinical data, including the last-recorded word recognition scores, were obtained from the patients' medical records.
   Results: New bone and new fibrous tissue were found in all 12 specimens, particularly at the site of cochleostomy. There was a significant correlation between overall damage to the lateral cochlear wall and the total volume of intracochlear new tissue (Spearman rho = .853; p = .0004). The total volume of new tissue did not correlate with word recognition scores or spiral ganglion cell counts.
   Conclusions: These preliminary results suggest that the degree of damage to the lateral cochlear wall may play an important role in influencing the amount of new tissue formation following cochlear implantation. Intracochlear new tissue does not appear to be an important determinant of performance as measured by word recognition scores or the total number of remaining spiral ganglion cells.
C1 Harvard Univ, Sch Med, Massachusetts Eye & Ear Infirm, Dept Otol & Laryngol, Boston, MA 02114 USA.
   MIT, Elect Res Lab, Boston, MA USA.
RP Nadol, JB (reprint author), Harvard Univ, Sch Med, Massachusetts Eye & Ear Infirm, Dept Otol & Laryngol, 243 Charles St, Boston, MA 02114 USA.
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   Guild SR, 1921, ANAT REC, V22, P141
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   Nadol JB, 2001, ANN OTO RHINOL LARYN, V110, P883
   Nadol Joseph B Jr, 2006, Adv Otorhinolaryngol, V64, P31
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   Wardrop P, 2005, HEARING RES, V203, P54, DOI 10.1016/j.heares.2004.11.006
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NR 21
TC 28
Z9 28
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD OCT
PY 2007
VL 116
IS 10
BP 731
EP 738
PG 8
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 221OC
UT WOS:000250236200004
PM 17987778
ER

PT J
AU Fowler, LP
   Morris, RJ
AF Fowler, Linda P.
   Morris, Richard J.
TI Comparison of fundamental frequency nasalance between trained singers
   and nonsingers for sung vowels
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT 33rd Annual Symposium of the Voice-Foundation
CY JUN 02-06, 2004
CL Philadelphia, PA
SP Voice Fdn
DE frequency; fundamental frequency nasalance; nonsinger; trained singer;
   velopharyngeal port; vowel
ID SUBGLOTTAL PRESSURE; VELOPHARYNGEAL FUNCTION; VOCAL INTENSITY; SPEECH;
   INDIVIDUALS; SPEAKING; PHONATION; PROFILES; SPEAKERS; CLOSURE
AB Objectives: The purpose of this study was to determine the effect of vocal training on fundamental frequency nasalance measures under selected vowel and frequency conditions.
   Methods: Fundamental frequency nasalance measures were reported for 2 groups of women: 36 trained singers and 36 nonsingers. Each group sang and sustained the vowels (/i/, /ae/, /u/, /a/) for 6 seconds' duration at 3 frequency levels. A 3-second segment from the middle of each vowel was measured to generate fundamental frequency nasalance scores.
   Results: No significant differences were found in the mean fundamental frequency nasalance scores between the trained singers and the nonsingers. The fundamental frequency nasalance scores were significantly higher for front vowels for both groups. Additionally, both groups displayed a pattern of producing significantly higher fundamental frequency nasalance scores at lower fundamental frequencies than at higher fundamental frequencies.
   Conclusions: These findings support the practice of training singers to elevate the velum when singing at high frequencies but not when singing at low ones.
C1 Florida State Univ, Dept Commun Disorders, Tallahassee, FL 32306 USA.
RP Fowler, LP (reprint author), Georgia State Univ, Commun Disorders Program, POB 4010, Atlanta, GA 30302 USA.
CR Austin SF, 1997, J VOICE, V11, P212, DOI 10.1016/S0892-1997(97)80080-X
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NR 45
TC 1
Z9 1
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD OCT
PY 2007
VL 116
IS 10
BP 739
EP 746
PG 8
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 221OC
UT WOS:000250236200005
PM 17987779
ER

PT J
AU Sato, K
   Nakashima, T
AF Sato, Kiminori
   Nakashima, Tadashi
TI Sleep-related Deglutition in children
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT 87th Annual Meeting of the American-Broncho-Esophagological-Association
CY APR 26-27, 2007
CL San Diego, CA
SP Amer Broncho Esophagol Assoc
DE child; deglutition; nocturnal swallowing; sleep; swallowing
AB Objectives: Clearance of the pharynx by deglutition is important in protecting the airway. The pattern of deglutition during sleep was investigated in children.
   Methods: Ten normal human children (8.6 +/- 2.9 years) were examined via time-matched recordings of polysomnography and of surface electromyography (EMG) of the thyrohyoid and suprahyoid muscles.
   Results: During sleep, deglutition was episodic, and it was absent for long periods. The mean number of swallows per hour ( +/- SD) during the total sleep time was 2.8 +/- 1.7 per hour. The mean period of the longest absence of deglutition was 59.7 +/- 20.3 minutes. Most deglutition occurred in association with spontaneous electroencephalographic arousal in rapid eye movement (REM) and non-REM sleep. Deglutition was related to sleep stage. The mean number of swallows per hour was 27.4 +/- 27.4 during stage 1 sleep, 3.1 +/- 3.5 during stage 2 sleep, 2.8 +/- 3.3 during stage 3 sleep, and 0.9 +/- 0.8 during stage 4 sleep. The deeper the sleep stage became, the lower the mean deglutition frequency became. The mean number of swallows per hour was 2.2 +/- 2.1 during REM sleep. The EMG amplitude dropped to the lowest level of recording during REM sleep.
   Conclusions: Deglutition, a vital function, is infrequent during sleep in children.
C1 Kurume Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, Kurume, Fukuoka 8300011, Japan.
RP Sato, K (reprint author), Kurume Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, 67 Asahi Machi, Kurume, Fukuoka 8300011, Japan.
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   LICHTER I, 1975, ELECTROEN CLIN NEURO, V38, P427, DOI 10.1016/0013-4694(75)90267-9
   Rechtschaffen A, 1968, MANUAL STANDARDIZED
   Sato K, 2006, ANN OTO RHINOL LARYN, V115, P334
NR 8
TC 6
Z9 6
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD OCT
PY 2007
VL 116
IS 10
BP 747
EP 753
PG 7
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 221OC
UT WOS:000250236200006
PM 17987780
ER

PT J
AU Yoshizaki, T
   Wakisaka, N
   Murono, S
   Kondo, S
   Shimizu, Y
   Takanaka, T
   Sanada, JI
   Terayama, N
   Matsui, O
   Furukawa, M
AF Yoshizaki, Tomokazu
   Wakisaka, Naohiro
   Murono, Shigeyuki
   Kondo, Satoru
   Shimizu, Yoshinori
   Takanaka, Tsuyoshi
   Sanada, Jun-Ichiro
   Terayama, Noboru
   Matsui, Osamu
   Furukawa, Mitsuru
TI Intra-arterial chemotherapy less intensive than RADPLAT with concurrent
   radiotherapy for resectable advanced head and neck squamous cell
   carcinoma: A prospective study
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE chemoradiotherapy; chemotherapy; head and neck cancer; intra-arterial
   chemotherapy; laryngeal cancer; salvage surgery
ID SALVAGE TOTAL LARYNGECTOMY; STAGE-IV HEAD; RADIATION-THERAPY; ORGAN
   PRESERVATION; CISPLATIN CHEMOTHERAPY; CANCER; CHEMORADIOTHERAPY;
   CHEMORADIATION; MANAGEMENT; ONCOLOGY
AB Objectives: This study was designed to evaluate the efficacy and feasibility of our intra-arterial chemotherapy protocol with a lower amount and frequency of cisplatin delivery than in RADPLAT for the treatment of resectable advanced head and neck cancer.
   Methods: Fifty-one patients with advanced squamous cell carcinoma of the oral cavity, oropharynx, hypopharynx, or larynx were included in this prospective study. The patients were treated with 3 courses of cisplatin (100 mg at 1 treatment, intra-arterial) and sodium thiosulfate (28 g at 1 treatment, intravenous) once every 2 weeks during concurrent radiotherapy (66 to 70 Gy, 2 Gy per fraction, daily for 5 days over 7 weeks). Nodal metastases larger than 3 cm in diameter were treated with an additional 50 mg of cisplatin. The patients with less than 50% tumor reduction after 40 Gy and 2 courses of chemotherapy were treated with surgery.
   Results: The protocol was completed for 49 patients. All living patients had a minimum follow-up period of 2 years. Including the 3 patients with salvage surgery, local disease-free control was achieved in 39 patients (80%). For 36 patients (73.5%), disease-free primary organs were preserved at 2 years after treatment. Locoregional disease-free control for 2 years was obtained for 38 patients (77.6%), in 30 of them without salvage surgery. The patients treated with surgery had an overall survival rate similar to that of the patients with a complete response (80% and 84.6%, respectively). The patients with a partial response had a worse prognosis (40%; p = .0069).
   Conclusions: This treatment regimen is feasible and effective for advanced resectable head and neck cancer.
C1 Kanazawa Univ, Grad Sch Med, Div Otolaryngol, Kanazawa, Ishikawa 9208641, Japan.
   Kanazawa Univ, Grad Sch Med, Div Radiol, Kanazawa, Ishikawa 9208641, Japan.
RP Yoshizaki, T (reprint author), Kanazawa Univ, Grad Sch Med, Div Otolaryngol, 13-1 Takaramachi, Kanazawa, Ishikawa 9208641, Japan.
RI Sanada, Junichiro/C-4687-2015
OI Sanada, Junichiro/0000-0001-8416-6355
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   Samant S, 2001, ARCH OTOLARYNGOL, V127, P1451
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   Wilson WR, 2001, ARCH OTOLARYNGOL, V127, P809
NR 20
TC 8
Z9 8
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD OCT
PY 2007
VL 116
IS 10
BP 754
EP 761
PG 8
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 221OC
UT WOS:000250236200007
PM 17987781
ER

PT J
AU Ohno, T
   Hirano, S
   Kanemaru, SI
   Yamashita, M
   Umeda, H
   Suehiro, A
   Tamura, Y
   Nakamura, T
   Ito, J
   Tabata, Y
AF Ohno, Tsunehisa
   Hirano, Shigeru
   Kanemaru, Shin-Ichi
   Yamashita, Masaru
   Umeda, Hiroo
   Suehiro, Atsushi
   Tamura, Yoshihiro
   Nakamura, Tatsuo
   Ito, Juichi
   Tabata, Yasuhiko
TI Drug delivery system of hepatocyte treatment of vocal fold scarring
   growth factor for the in a canine model
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT 87th Annual Meeting of the American-Broncho-Esophagological-Association
CY APR 26-27, 2007
CL San Diego, CA
SP Amer Broncho Esophagol Assoc
DE drug delivery system; gelatin hydrogel; hepatocyte growth factor; vocal
   fold scarring
ID CONTROLLED-RELEASE; RABBIT MODEL; REGENERATION; MATRIX; CELLS; RATS
AB Objectives: Vocal fold scarring remains a therapeutic challenge. Previous studies have indicated that hepatocyte growth factor (HGF), a strong antifibrotic element, has therapeutic potential for restoring scarred vocal folds. To enhance the effect of HGF in vivo, we developed a novel drug delivery system (DDS) in which HGF is embedded in gelatin hydrogel and continuously released over a period of 2 weeks. In the present study we investigated the therapeutic efficacy of the HGF DDS on vocal fold scarring by using a canine model.
   Methods: The vocal folds of 8 beagles were unilaterally scarred by stripping the entire layer of the lamina propria. The contralateral vocal folds were kept intact as normal controls. One month after the procedure, hydrogels (0.5 mL) containing 1 mu g of HGF were injected into the scarred vocal folds of 4 dogs (HGF-treated group), whereas hydrogels containing saline solution were injected in the other 4 dogs (sham group). Histologic and vibratory examinations were completed for each group 6 months after the initial surgery.
   Results: The excised larynx experiments showed significantly better vibration in terms of mucosal wave amplitude and glottal closure in the HGF-treated group compared to the sham group. Histologic evaluation of the vocal folds indicated remarkable reduction in collagen deposition and tissue contraction, with favorable restoration of hyaluronic acid and elastin in the HGF-treated group.
   Conclusions: The present findings suggest that the novel HGF DDS may provide favorable effects in restoring the vibratory properties of scarred vocal folds.
C1 Kyoto Univ, Grad Sch Med, Dept Otolaryngol Head & Neck Surg, Sakyo Ku, Kyoto 6068507, Japan.
   Kyoto Univ, Inst Frontier Med Sci, Dept Bioartificial Organs, Kyoto, Japan.
   Kyoto Univ, Inst Frontier Med Sci, Field Tissue Engn, Dept Biomat, Kyoto, Japan.
RP Ohno, T (reprint author), Kyoto Univ, Grad Sch Med, Dept Otolaryngol Head & Neck Surg, Sakyo Ku, 54 Shogoin Kawahara Cho, Kyoto 6068507, Japan.
RI Yamashita, Masaru/B-2411-2009
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NR 24
TC 29
Z9 31
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD OCT
PY 2007
VL 116
IS 10
BP 762
EP 769
PG 8
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 221OC
UT WOS:000250236200008
PM 17987782
ER

PT J
AU Kwon, TK
   Jeong, WJ
   Sung, MW
   Kim, KH
AF Kwon, Tack-Kyun
   Jeong, Woo-Jin
   Sung, Myung-Whun
   Kim, Kwang Hyun
TI Development of endoscopic arytenoid adduction using cricoid implant
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT Meeting of the American-Laryngological-Association
CY APR 26-27, 2007
CL San Diego, CA
SP Amer Laryngol Assoc
DE arytenoid adduction; cricoid implant; endoscopy; vocal fold paralysis
ID VOCAL CORD PARALYSIS; CRICOARYTENOID JOINT; COMPLICATIONS;
   MEDIALIZATION; THYROPLASTY
AB Objectives: We sought to develop a less-invasive alternative to conventional arytenoid adduction using a cricoid implant.
   Methods: We performed a preliminary study with excised human and canine larynges. A nail-shaped stainless steel rod and an insertion device were designed for an in vivo animal trial. After unilateral recurrent laryngeal denervation surgery in 5 adult mongrel dogs, the implants were inserted endoscopically through a small mucosal incision over the cricoarytenoid joint. Acoustic and aerodynamic data were obtained from each animal before serial euthanasia followed by examination of the excised larynges.
   Results: The canine cricoid cartilage demonstrated adequate marrow space for implantation. We found that the arytenoid cartilage was successfully medialized and tightly fixed over a sufficient period of time just by inserting an implant in the cricoid cartilage. The animal study showed that the implantation procedure was relatively easy and relatively safe. Acoustic and aerodynamic studies confirmed the functional improvement of the voice. Histopathologic study revealed a favorable tissue response to the implant.
   Conclusions: Endoscopic arytenoid adduction using a cricoid implant is feasible and could be a noninvasive surgical option for the treatment of unilateral vocal fold paralysis.
C1 Seoul Natl Univ, Coll Med, Dept Otorhinolaryngol, Seoul, South Korea.
RP Kim, KH (reprint author), Seoul Natl Univ Hosp, Dept Otorhinolaryngol, 28 Yongon Dong, Seoul 110744, South Korea.
RI Kwon, Tack-Kyun/J-5381-2012; Kim, Kwang Hyun/J-5385-2012
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NR 10
TC 3
Z9 6
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD OCT
PY 2007
VL 116
IS 10
BP 770
EP 778
PG 9
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 221OC
UT WOS:000250236200009
PM 17987783
ER

PT J
AU Trinidad, A
   Vicente, J
   Verdaguer, JM
   Daza, R
   Garcia-Berrocal, JR
   Ramirez-Camacho, R
AF Trinidad, Almudena
   Vicente, Javier
   Verdaguer, Jose Maria
   Daza, Rosa
   Garcia-Berrocal, Jose Ramon
   Ramirez-Camacho, Rafael
TI Morphological sequence of Plastipore extrusion in experimental otitis
   media
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE extrusion; middle ear; plastipore; rat
ID OSSICULAR REPLACEMENT PROSTHESES; MIDDLE-EAR; PSEUDOMONAS-AERUGINOSA;
   PORE; RECONSTRUCTION; IMPLANTS; MODEL; OSSICULOPLASTY; PROPLAST
AB Objectives: Plastipore prostheses are still used by many surgeons, although the functional results are controversial. The aim of this study was the morphological analysis of Plastipore material performance in the middle ear of rats, with special attention to extrusion.
   Methods: Twenty-four Wistar rats were given implants made of commercially available Plastipore and assigned to 3 groups: group A, with implantation in a healthy middle ear; group B, with implantation and cauterization of the nasopharyngeal orifice of the eustachian tube (hypoventilation); and group C, with implantation, cauterization of the eustachian tube, and bacterial inoculation with Pseudomonas aeruginosa.
   Results: The pathological study showed in nearly all cases the disintegration of the biomaterial. Adhesion between the biomaterial and bone could be seen in 1 rat from group C (hypoventilation and infection). In group C, the Plastipore was in contact with the tympanic membrane in 1 case and was extruding in 2 animals. Different phases of extrusion were defined. No extrusion was observed in the other groups.
   Conclusions: The sequential stages of Plastipore extrusion are demonstrated. Infection seems to be the most important factor in Plastipore extrusion in our model.
C1 Autonomous Univ Madrid, Univ Hosp Puerta Hierro, Ear Res Grp, Dept Otorhinolaryngol, E-28049 Madrid, Spain.
   Autonomous Univ Madrid, Univ Hosp Puerta Hiero, Ear Res Grp, Dept Microbiol, E-28049 Madrid, Spain.
RP Trinidad, A (reprint author), Hosp Univ Puerta Hierro, Serv Otorrinolaringol, San Martin Porres 4, Madrid 28035, Spain.
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NR 25
TC 0
Z9 0
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD OCT
PY 2007
VL 116
IS 10
BP 779
EP 784
PG 6
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 221OC
UT WOS:000250236200010
PM 17987784
ER

PT J
AU Tateya, L
   Tateya, T
   Surles, RL
   Tanumihardjo, S
   Bless, DM
AF Tateya, Lchiro
   Tateya, Tomoko
   Surles, Rebecca Lynn
   Tanumihardjo, Sherry
   Bless, Diane M.
TI Prenatal vitamin a deficiency causes laryngeal malformation in rats
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT Meeting of the American-Laryngological-Association
CY APR 26-27, 2007
CL San Diego, CA
SP Amer Laryngol Assoc
DE laryngeal development; rat model; vitamin A
ID STORING STELLATE CELLS; ACID RECEPTORS RARS; RETINOIC ACID; FETAL
   RESORPTION; DOUBLE MUTANTS; NEURAL CREST; VOCAL FOLD; HINDBRAIN;
   ABNORMALITIES; DEFECTS
AB Objectives: Our previous research demonstrated that vitamin A might be related to vocal fold development. The purpose of this study was to determine whether vitamin A deficiency affects prenatal laryngeal development in rats.
   Methods: Two considerations were necessary in designing a study using a rat model: for embryonic survival, vitamin A is necessary through day 10 of gestation, and laryngeal formation occurs primarily after day 11. Thus, we created a rat model that developed vitamin A deficiency after embryonic day 11. Ten pregnant rats (5 vitamin A-deficient rats and 5 control rats) were studied. Embryos were collected at embryonic day 18.5 and analyzed histologically.
   Results: Eighteen percent of the vitamin A-deficient embryos were alive and demonstrated laryngotracheal cartilage malformation, incomplete separation of the glottis, and/or laryngoesophageal clefts.
   Conclusions: These results document the important role played by vitamin A in laryngeal development.
C1 Univ Wisconsin, Div Otolaryngol Head & Neck Surg, Dept Surg, Madison, WI USA.
   Univ Wisconsin, Dept Nutr Sci, Madison, WI USA.
   Kyoto Univ, Grad Sch Med, Dept Otolaryngol Head & Neck Surg, Kyoto, Japan.
RP Tateya, L (reprint author), Kyoto Katsura Hosp, Dept Otolaryngol, Nishikyo Ku, 17 Yamada Hirao Cho, Kyoto, Japan.
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NR 27
TC 4
Z9 4
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD OCT
PY 2007
VL 116
IS 10
BP 785
EP 792
PG 8
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 221OC
UT WOS:000250236200011
ER

PT J
AU Zeitels, SM
   Blitzer, A
   Hillman, RE
   Anderson, RR
AF Zeitels, Steven M.
   Blitzer, Andrew
   Hillman, Robert E.
   Anderson, R. Rox
TI Foresight in laryngology and laryngeal surgery: A 2020 vision
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT 85th Annual Meeting of the American-Broncho-Esophagological-Association
CY MAY 13-14, 2005
CL Boca Raton, FL
SP Amer Broncho Esophagol Assoc
DE cancer; glottis; laryngology; laryngoscopy; larynx; laser; vocal cord;
   vocal fold; voice
ID OPTICAL COHERENCE TOMOGRAPHY; VOCAL-FOLD COLLISION; TOPICAL MITOMYCIN-C;
   PULSED DYE-LASER; VOICE QUALITY; LARYNGOTRACHEAL RECONSTRUCTION;
   ELECTROMYOGRAPHIC ACTIVITY; ENDOSCOPIC EVALUATION; GLOTTAL DYSPLASIA;
   BOTULINUM TOXIN
AB Laryngology and laryngeal surgery have been in the vanguard of minimally invasive human procedural interventions for approximately 150 years. The natural passages through the oral cavity, nose, and pharynx have provided an accessible gateway to the larynx that has allowed for rapid translation of a variety of diagnostic and therapeutic technologies. Transoral and transcervical laryngeal surgery have been further facilitated by progressive advancements in local, topical, intravenous, and general anesthesia. With rapid developments in engineering disciplines (ie, tissue, chemical, mechanical) and voice science, there are a variety of current and near-term opportunities to advance our field. This report represents a panel at the 2005 American Broncho-Esophagological Association meeting that sought to use present perspectives, combined with cutting-edge research insights, to provide foresight into key aspects of laryngology that we believe will be developed by the year 2020. We hope that aspiring laryngeal surgeons will find elements of this discussion valuable for devising a strategic roadmap for research initiatives in laryngology and laryngeal surgery.
C1 Massachusetts Gen Hosp, Ctr Laryngeal Surg & Voice Rehabil, Boston, MA 02114 USA.
   Harvard Univ, Sch Med, Dept Surg, Boston, MA USA.
   Harvard Univ, Sch Med, Dept Dermatol, Boston, MA USA.
   Massachusetts Gen Hosp, Wellman Labs Photomed, Boston, MA 02114 USA.
   Columbia Univ, New York Ctr Voice & Swallowing Disorders, Dept Clin Otolaryngol, New York, NY USA.
RP Zeitels, SM (reprint author), Massachusetts Gen Hosp, Ctr Laryngeal Surg & Voice Rehabil, 1 Bowdon Sq,11th Floor, Boston, MA 02114 USA.
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NR 102
TC 3
Z9 3
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD SEP
PY 2007
VL 116
IS 9
SU 198
BP 2
EP 16
PN 2
PG 15
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 213TM
UT WOS:000249690000001
ER

PT J
AU Morris, LG
   Zoumalan, RA
   Roccaforte, JD
   Amin, MR
AF Morris, Luc G.
   Zoumalan, Richard A.
   Roccaforte, J. David
   Amin, Milan R.
TI Monitoring tracheal tube cuff pressures in the intensive care unit: A
   comparison of digital palpation and manometry
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT 87th Annual Meeting of the American-Broncho-Esophagological-Association
CY APR 26-27, 2007
CL San Diego, CA
SP Amer Broncho Esophagol Assoc
DE cuff; intubation; pressure; trachea; tracheotomy
ID ENDOTRACHEAL INTUBATION; BLOOD-FLOW
AB Objectives: Tracheal tube cuff overinflation is a recognized risk factor for tracheal injury and stenosis. International studies report a 55% to 62% incidence of cuff overinflation among intensive care unit (ICU) patients. However, there are no data on tracheotomy tubes, and no recent data from ICUs in the United States. It is unknown whether routine cuff pressure measurement is beneficial. We sought to determine the incidence of cuff overinflation in the contemporary American ICU.
   Methods: We performed an Institutional Review Board-approved, prospective, observational study of endotracheal and tracheotomy tubes at 2 tertiary-care academic hospitals that monitor cuff pressure differently. At hospital A, cuff pressures are assessed by palpation; at hospital B, cuff pressures are measured via manometry. We audited cuff pressures in an unannounced fashion at these hospitals, using a handheld aneroid manometer. Cuffs were considered overinflated above 25 cm H2O.
   Results: We enrolled 115 patients: 63 at hospital A and 52 at hospital B. Overall, 44 patients (38%) were found to have overinflated cuffs. The incidence of overinflation was identical at the 2 hospitals (38%; p = .99). Of the endotracheal tubes, 43% were overinflated, as were 32% of the tracheotomy tubes (p = .24).
   Conclusions: Despite increasing awareness among intensivists and respiratory therapists, the incidence of tracheal tube overinflation remains high, with both endotracheal and tracheotomy tubes. Our finding that the use of manometry to assess cuff pressures did not reduce the incidence of overinflation suggests that a more vigilant management protocol may be necessary.
C1 NYU, Sch Med, Dept Otolaryngol, New York, NY 10016 USA.
   NYU, Sch Med, Dept Anesthesiol, Div Crit Care, New York, NY 10016 USA.
RP Amin, MR (reprint author), NYU, Sch Med, Dept Otolaryngol, 550 1st Ave,NBV 5E5, New York, NY 10016 USA.
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NR 16
TC 15
Z9 17
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD SEP
PY 2007
VL 116
IS 9
BP 639
EP 642
PN 1
PG 4
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 211RW
UT WOS:000249542000001
PM 17926583
ER

PT J
AU Davis, MV
   Merati, AL
   Jaradeh, SS
   Blumin, JH
AF Davis, Melinda V.
   Merati, Albert L.
   Jaradeh, Safwan S.
   Blumin, Joel H.
TI Myosin heavy chain composition and fiber size of the cricopharyngeus
   muscle in patients with achalasia and normal subjects
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE cricopharyngeus; dysphagia; myosin
ID UPPER ESOPHAGEAL SPHINCTER; SINGLE-FIBER; PLASTICITY
AB Objectives: Cricopharyngeal achalasia (CA) can be defined as inadequate opening of the cricopharyngeus muscle (CPM) resulting in dysphagia. Myosin heavy chain (MHC) isoform fiber type cornposition and size are key determinants of muscle function. These parameters have not been described in CA. It is hypothesized that there is a difference between the MHC isoform composition of the CPM in patients with the clinical diagnosis of CA and that in normal subjects.
   Methods: Patients who had received prior botulinum were excluded. The MHC fiber type composition and size in patients and cadaveric controls were determined by adenosine triphosphatase staining and image analysis.
   Results: The CPMs of 12 CA patients (6 male, 6 female; mean age, 61 years) and 5 control cadaveric Subjects (3 male, 2 female; mean age, 67 years) were analyzed. There were relatively fewer type I fibers (67%) in patients with CA than in controls (81%), but the difference was not significant (p = .18). Type I fibers were slightly smaller in CA patients (38.7 mu m) than in controls (47.2 mu m), but this was not significantly different (p > .05). Of the 12 CA patients, 3 had type II predominance, a feature not seen in normal Subjects.
   Conclusions: Patients with CA had relatively fewer type I fibers, although the difference was not statistically significant. The MHC isoform composition and fiber size were not different between CA patients and normal subjects. This is the first report to characterize the CPM in patients with CA.
C1 Med Coll Wisconsin, Div Laryngol & Profess Voice, Dept Otolaryngol & Commun Sci, Milwaukee, WI 53226 USA.
   Med Coll Wisconsin, Dept Neurol, Milwaukee, WI 53226 USA.
RP Blumin, JH (reprint author), 9200 W Wisconsin Ave, Milwaukee, WI 53226 USA.
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NR 13
TC 3
Z9 3
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD SEP
PY 2007
VL 116
IS 9
BP 643
EP 646
PN 1
PG 4
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 211RW
UT WOS:000249542000002
PM 17926584
ER

PT J
AU Catalano, PJ
   Dolan, R
   Romanow, J
   Payne, SC
   Silverman, M
AF Catalano, Peter J.
   Dolan, Robert
   Romanow, John
   Payne, Spencer C.
   Silverman, Mark
TI Correlation of bone SPECT scintigraphy with histopathology of the
   ethmoid bulla: Preliminary investigation
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE bone; chronic rhinosinusitis; ethmoid bulla; histopatholoay; osteitis;
   single photon emission computed tomography; SPECT; technetium
   99m-methylene diphosphonate
ID ENDOSCOPIC SINUS SURGERY; CHRONIC RHINOSINUSITIS; MAXILLARY SINUS;
   TOMOGRAPHY; OSTEITIS
AB Objectives: Reports in the rhinology literature suggest that osteitis of the ethmoid bone may be responsible for refractory and/or recurrent sinusitis. If so, bone scanning technologies capable of detecting osteitis may be useful in diagnosing this condition and its response to treatment. The objective of this prospective cohort Study was to determine the correlation of single photon emission Computed tomography (SPECT) bone scintigraphy with the histopathology of the ethmoid bulla.
   Methods: Thirty-six patients with a diagnosis of chronic sinusitis who were scheduled to undergo Sinus surgery underwent a presurgical SPECT bone scan using technetium 99m-methylene diphosphonate. All bone scans were done within 5 days of surgery. During the procedure, bone samples from the face of the ethmoid bulla were obtained and examined by a pathologist blinded to the bone scan result. In this Study, histopathology consistent with osteitis was defined as a change from lamellar to woven bone. A positive bone scan was defined by the presence of increased radiotracer uptake in the ethmoid Sinuses.
   Results: Thirty-two of the 36 patients had a positive bone scan on SPECT imaging, and 31 specimens demonstrated histopathologic bone changes consistent with osteitis, for a sensitivity of 93.9%. An additional 4 patients had a negative bone scan on SPECT imaging, and osteitis was identified in 2 of the 4. The specificity was 66.7%, and the positive predictive value was 96.9%.
   Conclusions: We found that SPECT bone scanning with technetium 99m-methylene diphosphonate is a highly sensitive test for identifying osteitis in patients with chronic rhinosinusitis. It may be a useful tool in the armamentarium of the otolaryngologist to better define this disease process.
C1 Lahey Clin Fdn, Dept Otorhinolaryngol Head & Neck Surg, Burlington, MA 01805 USA.
   Lahey Clin Fdn, Dept Pathol, Burlington, MA 01805 USA.
RP Catalano, PJ (reprint author), Lahey Clin Fdn, Dept Otorhinolaryngol Head & Neck Surg, 41 Mall Rd, Burlington, MA 01805 USA.
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NR 18
TC 5
Z9 5
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD SEP
PY 2007
VL 116
IS 9
BP 647
EP 652
PN 1
PG 6
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 211RW
UT WOS:000249542000003
PM 17926585
ER

PT J
AU Casselbrant, ML
   Mandel, EM
   Sparto, PJ
   Redfern, MS
   Furman, JM
AF Casselbrant, Margaretha L.
   Mandel, Ellen M.
   Sparto, Patrick J.
   Redfern, Mark S.
   Furman, Joseph M.
TI Contribution of vision to balance in children four to eight years of age
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE balance; optic flow; posture
ID MIDDLE-EAR EFFUSION; POSTURAL CONTROL; OTITIS-MEDIA; VISUAL
   PROPRIOCEPTION; YOUNG-CHILDREN; OPTICAL-FLOW; INFANTS; SWAY;
   SENSITIVITY; VALIDATION
AB Objectives: The use of sensory feedback for postural control develops throughout childhood. The aim of this study was to determine how children use cues from anterior-posterior optic flow for balance from 4 to 8 years of age.
   Methods: One hundred forty-eight children were enrolled. The subjects had yearly otologic and posturographic examinations between the ages of 4 and 8 years. Balance was assessed only if the subject had no evidence of middle ear effusion. The subject stood for 30 seconds with eyes open without optic flow and for 30 seconds while viewing 0.1, 0.25, and 0.4 Hz anterior-posterior optic flow. The center of pressure (COP) was recorded from the force platform. The root-mean-square of the COP during the periods of quiet stance and with optic flow was computed.
   Results: The root-mean-square COP was significantly larger during the optic flow stimulation as compared with during quiet stance. The subjects had a significant decrease in COP during optic flow from year 5 to year 6 of life (p = .005).
   Conclusions: A change in the response to optic flow was seen from age 5 to age 6. This change is consistent with transitional changes in postural responses that have been observed during quiet standing.
C1 Childrens Hosp Pittsburgh, Dept Pediat Otolaryngol, Pittsburgh, PA 15213 USA.
   Univ Pittsburgh, Sch Med, Dept Otolaryngol, Pittsburgh, PA USA.
RP Casselbrant, ML (reprint author), Childrens Hosp Pittsburgh, ENT Dept, 3705 5th Ave, Pittsburgh, PA 15213 USA.
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NR 26
TC 5
Z9 6
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD SEP
PY 2007
VL 116
IS 9
BP 653
EP 657
PN 1
PG 5
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 211RW
UT WOS:000249542000004
PM 17926586
ER

PT J
AU Alexander, AAZ
   Patel, AA
   Odland, R
AF Alexander, Alan A. Z.
   Patel, Alpen A.
   Odland, Rick
TI Paranasal sinus osteomas and Gardner's syndrome
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE familial adenomatous polyposis; Gardner's syndrome; sinus osteoma
ID FAMILIAL ADENOMATOUS POLYPOSIS; EXTRACOLONIC MANIFESTATIONS;
   COLORECTAL-CANCER; CARCINOMA; ASSOCIATION; MANAGEMENT; REGION
AB Objectives: Osteomas are common benign tumors of the paranasal sinuses. The origin of these lesions is uncertain. Although most are asymptomatic, symptoms can include headaches, facial pain, rhinorrhea, and sinusitis. Osteomas are also seen as part of Gardner's syndrome, an autosomal dominant disease characterized by intestinal polyposis, osteomas, and cutaneous and soft tissue tumors. In affected individuals, the risk of developing colon cancer approaches 100%. On average, osteomas are detected 17 years before colon polyps appear.
   Methods: Three patients with maxillary or ethmoid osteomas and chronic sinusitis are presented.
   Results: One of the patients had evidence of Gardner's syndrome, based on the presence of gastrointestinal symptoms and a positive family history of polyposis.
   Conclusions: Otolaryngologists should be aware of the possibility of Gardner's syndrome in patients with paranasal sinus osteomas. Suspected patients should have a complete workup for Gardner's syndrome, including lower gastrointestinal tract endoscopy, barium enema imaging, and DNA testing.
C1 Emory Univ, Dept Otolaryngol, Atlanta, GA 30308 USA.
   Univ Minnesota, Dept Otolaryngol, Hennepin Cty Med Ctr, Minneapolis, MN USA.
RP Patel, AA (reprint author), Emory Univ, Dept Otolaryngol, Med Off Tower,550 Peachtree St,NE,9th Floor,Suite, Atlanta, GA 30308 USA.
CR AULAKH SK, 2005, FERRIS CLIN ADVISOR, P324
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NR 25
TC 12
Z9 13
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD SEP
PY 2007
VL 116
IS 9
BP 658
EP 662
PN 1
PG 5
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 211RW
UT WOS:000249542000005
PM 17926587
ER

PT J
AU Naumann, IC
   Cordes, SR
AF Naumann, Ilka Charlotte
   Cordes, Susan R.
TI Giant basal cell carcinoma of the forehead with extensive intracranial
   involvement
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE basal cell carcinoma; intracranial involvement; invasion
ID INVASION
AB Basal cell carcinoma (BCC) is the most common malignant skin lesion and is frequently curatively treated with local excision. Improper removal or neglect of BCC is a particular problem for head and neck surgeons. We describe a case of a recurrent BCC that aggressively grew from the forehead skin through the skull and into the frontal lobe. We also present a review of the literature. Despite its fairly benign growth pattern, BCC should never be underestimated, and care should be taken not only in the complete primary excision but also in cancer surveillance.
C1 Indiana Univ, Dept Otorhinolaryngol Head & Neck Surg, Indianapolis, IN 46202 USA.
RP Cordes, SR (reprint author), Indiana Univ, Dept Otorhinolaryngol Head & Neck Surg, 702 Barnhill Dr,RI0860, Indianapolis, IN 46202 USA.
CR American Cancer Society, 2001, CANC FACTS FIG 2001
   Asilian A, 2005, DERMATOL SURG, V31, P1468
   Aygit C, 2006, J ORAL MAXIL SURG, V64, P1143, DOI 10.1016/j.joms.200603.023
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NR 10
TC 6
Z9 6
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD SEP
PY 2007
VL 116
IS 9
BP 663
EP 666
PN 1
PG 4
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 211RW
UT WOS:000249542000006
PM 17926588
ER

PT J
AU Angeli, S
   Connell, S
   Gibson, B
   Ozdek, A
   McElveen, JT
   Van De Water, TR
AF Angeli, Simon
   Connell, Sarah
   Gibson, Brian
   Ozdek, Ali
   McElveen, John T., Jr.
   Van De Water, Thomas R.
TI Injectable form of cross-linked hyaluronan is effective for middle ear
   wound healing
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT 110th Annual Meeting of the
   American-Academy-of-Otolaryngology-Head-and-Neck-Surgery
CY SEP 17-20, 2006
CL Toronto, CANADA
SP Amer Acad Otolaryngol Head & Neck Surg
DE adhesion; hyaluronan; hyaluronic acid; middle ear; ototoxicity;
   tympanoplasty
ID TYMPANIC MEMBRANE PERFORATIONS; ABSORBABLE GELATIN SPONGE; INNER-EAR;
   ACID; RAT
AB Objectives: Two studies were designed to investigate a hyaluronan (HA) gel for middle ear (ME) wound healing.
   Methods: We used a guinea pig model of ME wound healing. In a long-term study, we performed a comparison of hearing and ME inflammation in 3 groups. Group 1 (n = 8) underwent bilateral wounding of ME mucosa and unilateral packing of the ME with HA gel (Sepragel). Group 2 (n = 6) was the same as group 1 except that the packing was absorbable bovine collagen sponges (Gelfoam). Group 3, the control group (n 14), had operated, unpacked ears. In a short-term study, we investigated ME retention of HA gel at 1 and 2 weeks (n 16).
   Results: At 1 week, all ears showed decreased distortion product otoacoustic emissions (DPOAEs) and auditory brain stem responses (ABRs) secondary to ME packing and postsurgical inflammation. The controls recovered preoperative DPOAEs and ABRs by week 2. Group 1 had decreased low-frequency DPOAEs at weeks 2 and 6, but their high-frequency DPOAEs and ABRs recovered to preoperative values by week 6. Group 2 had hearing losses that persisted throughout the study. Group 1 showed normal ME and inner ear histologic characteristics. Group 2 showed inflammatory cells within the ME and cochleas. Group 1 showed less packing retention than did group 2 at week 6 (p = .016). Eighty-five percent of the HA packing remained at 1 week, and 73% at 2 weeks.
   Conclusions: Hyaluronan gel was a relatively safe and effective ME packing material in our animal model.
C1 Univ Miami, Ear Inst, Dept Otolaryngol, Miller Sch Med, Miami, FL 33136 USA.
   Carolina Ear Res Inst, Raleigh, NC USA.
RP Van De Water, TR (reprint author), Univ Miami, Ear Inst, Dept Otolaryngol, Miller Sch Med, 1600 NW 10th Ave,RMSB 3160, Miami, FL 33136 USA.
CR Angeli SI, 2006, OTOLARYNG HEAD NECK, V134, P225, DOI 10.1016/j.otohns.2005.09.028
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   HELLSTROM S, 1987, ACTA OTO-LARYNGOL, P54
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   Krupala JL, 1998, AM J OTOL, V19, P546
   LAURENT C, 1988, ARCH OTOLARYNGOL, V114, P1435
   LAURENT C, 1986, AM J OTOLARYNG, V7, P181, DOI 10.1016/S0196-0709(86)80004-7
   LAURENT C, 1988, ACTA OTO-LARYNGOL, V105, P273, DOI 10.3109/00016488809097008
   LAURENT C, 1986, AM J OTOLARYNG, V7, P334, DOI 10.1016/S0196-0709(86)80021-7
   LAURENT TC, 1987, ACTA OTO-LARYNGOL, P7
   Li G, 2001, ARCH OTOLARYNGOL, V127, P534
   Liening DA, 1997, OTOLARYNG HEAD NECK, V116, P454, DOI 10.1016/S0194-5998(97)70294-8
   Martini A, 2000, AM J OTOL, V21, P468
   SPANDOW O, 1992, ACTA OTO-LARYNGOL, P90
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NR 16
TC 7
Z9 8
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD SEP
PY 2007
VL 116
IS 9
BP 667
EP 673
PN 1
PG 7
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 211RW
UT WOS:000249542000007
PM 17926589
ER

PT J
AU Oikawa, K
   Furuta, Y
   Nakamaru, Y
   Oridate, N
   Fukuda, S
AF Oikawa, Keita
   Furuta, Yasushi
   Nakamaru, Yuji
   Oridate, Nobuhiko
   Fukuda, Satoshi
TI Preoperative staging and surgical approaches for sinonasal inverted
   papilloma
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE endoscopic sinus surgery; medial maxillectomy; sinonasal inverted
   papilloma; staging system
ID ENDOSCOPIC MEDIAL MAXILLECTOMY; SINUS SURGERY; MANAGEMENT
AB Objectives: We sought to determine the value of preoperative staging by magnetic resonance imaging (MRI) assessment in the surgical management of sinonasal inverted papillomas (IPs).
   Methods: Preoperative MRI staging was used to assess 22 patients with IPs. In addition to the Krouse staging system, T3 cases were categorized as subgroup T3-B if tumors extended into the frontal sinus or the supraorbital recess; otherwise, they were categorized as T3-A. Standard endoscopic sinus surgery (ESS) was the first choice for T1 and T2 cases. Endoscopic approaches, including ESS combined with endoscope-assisted transantral approach and endoscopic medial maxillectomy, were considered in T3-A cases, and external approaches were considered in T3-B cases. Patients were followed for a minimum of 1 year after surgery.
   Results: Preoperative MRI staging and postoperative staging were coincident in 21 of the 22 patients (95%). All 8 T2 cases were treated by an endoscopic approach. Of 10 T3-A cases, 9 (90%) were treated by an endoscopic approach and 1 (residual case) was treated by an external approach. All 3 of the T3-B cases underwent an external approach. One T4 case with malignant transformation underwent an external approach followed by radiotherapy. After a median follow-up period of 22 months, none of the 22 patients had had a recurrence. No major complications were observed after endoscopic approaches, but epiphora or hemorrhage requiring transfusion occurred in 3 of the 5 patients (60%) who underwent external approaches.
   Conclusions: Preoperative staging of IP by MRI is useful for selecting cases that can be managed by endoscopic approaches, resulting in lower rates of tumor recurrence and morbidity.
C1 Hokkaido Univ, Grad Sch Med, Dept Otolaryngol Head & Neck Surg, Kita Ku, Sapporo, Hokkaido 0608638, Japan.
RP Furuta, Y (reprint author), Hokkaido Univ, Grad Sch Med, Dept Otolaryngol Head & Neck Surg, Kita Ku, Kita 15,Nishi 7, Sapporo, Hokkaido 0608638, Japan.
RI Fukuda, Satoshi/A-8433-2012; Nakamaru, Yuji/G-5441-2012; Oridate,
   Nobuhiko/G-5365-2012
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   Han JK, 2001, LARYNGOSCOPE, V111, P1395, DOI 10.1097/00005537-200108000-00015
   Kamel R, 2005, AM J RHINOL, V19, P358
   KAMEL RH, 1995, LARYNGOSCOPE, V105, P847, DOI 10.1288/00005537-199508000-00015
   Katori H, 2005, AURIS NASUS LARYNX, V32, P257, DOI 10.1016/j.anl.2005.03.015
   Kraft M, 2003, LARYNGOSCOPE, V113, P1541, DOI 10.1097/00005537-200309000-00025
   Krouse JH, 2000, LARYNGOSCOPE, V110, P965, DOI 10.1097/00005537-200006000-00015
   Krouse JH, 2001, AM J OTOLARYNG, V22, P87, DOI 10.1053/ajot.2001.22563
   Lawson W, 2003, LARYNGOSCOPE, V113, P1548, DOI 10.1097/00005537-200309000-00026
   Lee TJ, 2004, HEAD NECK-J SCI SPEC, V26, P145, DOI 10.1002/hed.10350
   MAY M, 1993, RHINOLOGY SINUSOLOGY, P193
   Minovi A, 2006, RHINOLOGY, V44, P205
   Oikawa K, 2007, ANN OTO RHINOL LARYN, V116, P297
   Oikawa K, 2003, LARYNGOSCOPE, V113, P1983, DOI 10.1097/00005537-200311000-00024
   Sukenik MA, 2000, LARYNGOSCOPE, V110, P39, DOI 10.1097/00005537-200001000-00008
   Tomenzoli D, 2004, LARYNGOSCOPE, V114, P193, DOI 10.1097/00005537-200402000-00003
   Tufano RP, 1999, AM J RHINOL, V13, P423, DOI 10.2500/105065899781329665
   Von Buchwald C, 2005, OTOLARYNG HEAD NECK, V132, P602, DOI 10.1016/j.otohns.2005.01.016
   WAITZ G, 1992, LARYNGOSCOPE, V102, P917, DOI 10.1288/00005537-199208000-00012
   Wolfe SG, 2004, OTOLARYNG HEAD NECK, V131, P174, DOI 10.1016/j.otohns.2004.05.011
   Zweig JL, 2000, AM J RHINOL, V14, P27, DOI 10.2500/105065800781602902
NR 22
TC 6
Z9 7
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD SEP
PY 2007
VL 116
IS 9
BP 674
EP 680
PN 1
PG 7
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 211RW
UT WOS:000249542000008
PM 17926590
ER

PT J
AU Yoshida, H
   Takahashi, H
   Morikawa, M
   Kobayashi, T
AF Yoshida, Haruo
   Takahashi, Haruo
   Morikawa, Minoru
   Kobayashi, Toshimitsu
TI Anatomy of the bony portion of the eustachian tube in tubal stenosis:
   multiplanar reconstruction approach
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE chronic otitis media; computed tomography; eustachian tube; multiplanar
   reconstruction; temporal bone
ID OTITIS-MEDIA; AUDITORY TUBE; MIDDLE-EAR; CT; LUMEN; PNEUMATIZATION;
   EFFUSION
AB Objectives: We sought to clarify possible pathological conditions of the bony portion of the eustachian tube (ET) in patients with ET stenosis.
   Methods: We measured the total length, the cross-sectional area of the bony frame, and the air space of the ET lumen at an interval of 1 mm on the reconstructed computed tomographic images of the ET using a multiplanar reconstruction method on 20 normal subjects (control group) and 25 patients with stenotic ET judged by the inflation test (stenotic group).
   Results: In the cross-sectional areas, both the bony frame and air space were significantly smaller in the stenotic group than in the control group. The soft tissue ratio was significantly greater in most parts of the mid-bony portion and the tympanic orifice of the stenotic group than in those of the control group. At the anterior tip of the bony portion, only the bony frame was found to be significantly smaller in the stenotic group than in the control group.
   Conclusions: We suggest that a smaller framework of the bony ET may possibly be related to the pathogenesis of ET stenosis.
C1 Nagasaki Univ, Grad Sch Biomed Sci, Dept Otolaryngol Head & Neck Surg, Nagasaki 8528501, Japan.
   Nagasaki Univ, Grad Sch Biomed Sci, Dept Radiol & Radiat Biol, Div Radiol Sci, Nagasaki 8528501, Japan.
   Tohoku Univ, Grad Sch Med, Dept Otolaryngol Head & Neck Surg, Sendai, Miyagi 980, Japan.
RP Yoshida, H (reprint author), Nagasaki Univ, Grad Sch Biomed Sci, Dept Otolaryngol Head & Neck Surg, 1-7-1 Sakamoto, Nagasaki 8528501, Japan.
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   Bluestone CD, 2005, ANN OTO RHINOL LARYN, V114, P16
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NR 27
TC 1
Z9 2
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD SEP
PY 2007
VL 116
IS 9
BP 681
EP 686
PN 1
PG 6
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 211RW
UT WOS:000249542000009
PM 17926591
ER

PT J
AU Deguchi, S
   Ishimaru, Y
   Washio, S
AF Deguchi, Shinji
   Ishimaru, Yuuki
   Washio, Seiichi
TI Preliminary evaluation of stroboscopy system using multiple light
   sources for observation of pathological vocal fold oscillatory pattern
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE computer-assisted diagnosis; image analysis; light-emitting diode;
   pathological condition; stroboscopy; vocal fold
ID VOICE; DIPLOPHONIA; VIBRATION; DISEASE
AB Objectives: Laryngostroboscopy is used to check the oscillatory patterns of the vocal folds. However, the use of one single flash timing cannot give a clear view of abnormal vocal fold oscillations that have multiple fundamental frequencies. Visualization of such complex vocal fold movements will be helpful in the diagnosis of diplophonia, a pathological condition in which the vocal folds produce multiple tones at the same time.
   Methods: We developed a new stroboscopy-based technique using multiple light-emitting diodes (LEDs) and image analysis. Specific flash timings for each LED, suitable for accurate visualization, were determined on a computer according to an algorithm based on frequency analysis. The image analysis extracted the necessary parts of the captured images to yield a clear slow-motion view of the oscillations. The series of visualization procedures took advantage of the narrow-spectrum light property of LEDs, thereby yielding a degradation-free picture.
   Results: Feasibility tests using a mechanical vocal fold model demonstrated that this computer-assisted system allows observation of the pathological oscillatory patterns as one single video. They would not be clearly visualized by conventional stroboscopy.
   Conclusions: Because of its relatively simple use and inexpensive construction, the proposed technique can become one potential option for clinical assessment of pathological vocal fold oscillations.
C1 Okayama Univ, Grad Sch Nat Sci & Technol, Div Ind Innovat Sci, Okayama, Japan.
RP Deguchi, S (reprint author), Tsushima Naka 3-1-1, Okayama 7008530, Japan.
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   Speyer R, 2002, ANN OTO RHINOL LARYN, V111, P902
   WONG D, 1991, J ACOUST SOC AM, V89, P383, DOI 10.1121/1.400472
NR 14
TC 4
Z9 4
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD SEP
PY 2007
VL 116
IS 9
BP 687
EP 694
PN 1
PG 8
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 211RW
UT WOS:000249542000010
PM 17926592
ER

PT J
AU Eadie, TL
   Nicolici, C
   Baylor, C
   Almand, K
   Waugh, P
   Maronian, N
AF Eadie, Tanya L.
   Nicolici, Christina
   Baylor, Carolyn
   Almand, Kimberly
   Waugh, Patricia
   Maronian, Nicole
TI Effect of experience on judgments of adductor spasmodic dysphonia
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT Annual Convention of the American-Speech-Language-Hearing-Associatioin
CY NOV 16-18, 2006
CL Miami, FL
SP Amer Speech Language Hear Assoc
DE adductor spasmodic dysphonia; perceptual voice judgments; voice handicap
ID BOTULINUM TOXIN INJECTIONS; LIFE V-RQOL; VOICE QUALITY; PERCEPTUAL
   EVALUATION; SEVERITY
AB Objectives: We performed a prospective, exploratory study 1) to determine differences in judgments of overall severity (OS) and vocal effort (VE) in adductor spasmodic dysphonia (ADSD) when judgments are made by experienced listeners, naive listeners, and speakers with ADSD; 2) to determine differences in judgments of listener comfort (LC) in ADSD when judgments are made by experienced and naive listeners; and 3) to determine relationships between auditory-perceptual ratings of voice and speakers' voice handicap.
   Methods: Twenty speakers with ADSD provided speech recordings. They judged their own speech samples for OS and VE and completed the Voice Handicap Index (VHI). Twenty naive and 8 experienced listeners evaluated speech samples for OS, VE, and LC using rating scales.
   Results: No differences were found for judgments of OS, VE, or LC across the groups. However, the strategies used by the speakers seemed to differ from those used by the other listeners in making OS and VE judgments. The speakers' self-judged VE correlated moderately with voice handicap; experienced and naive listeners' judgments were only weakly related to VHI scores.
   Conclusions: Speakers with ADSD and listeners appear to use auditory-perceptual dimensions differently. Voice handicap is best predicted by patient-perceived VE, and not by clinician or naive listeners' judgments.
C1 Univ Washington, Dept Speech & Hearing Sci, Seattle, WA 98105 USA.
   Univ Washington, Dept Rehabil Med, Seattle, WA 98105 USA.
   Univ Washington, Dept Otolaryngol Head & Neck Surg, Seattle, WA 98105 USA.
RP Eadie, TL (reprint author), Univ Washington, Dept Speech & Hearing Sci, 1417 NE 42nd St, Seattle, WA 98105 USA.
CR *AV INN INC, 2004, EXP GEN CONTR WIND E
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   Lee M, 2005, CLIN OTOLARYNGOL, V30, P357, DOI 10.1111/j.1365-2273.2005.01022.x
   Murry T, 2004, J VOICE, V18, P183, DOI 10.1016/j.jvoice.2003.11.003
   O'Brian S, 2003, J SPEECH LANG HEAR R, V46, P503, DOI 10.1044/1092-4388(2003/041)
   SAPIR S, 1986, ANN OTO RHINOL LARYN, V95, P137
   Stewart CF, 1997, J VOICE, V11, P95, DOI 10.1016/S0892-1997(97)80029-X
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NR 21
TC 13
Z9 13
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD SEP
PY 2007
VL 116
IS 9
BP 695
EP 701
PN 1
PG 7
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 211RW
UT WOS:000249542000011
PM 17926593
ER

PT J
AU Liess, BD
   Hirschi, S
   Zitsch, RP
   Frazier, S
   Konrad, A
AF Liess, Benjamin D.
   Hirschi, Scot
   Zitsch, Robert P., III
   Frazier, Shellaine
   Konrad, Angela
TI Carcinosarcoma of the parotid gland: Report of a case with
   immunohistochemical findings
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE carcinosarcoma; malignant mixed tumor; malignant parotid tumor
ID MALIGNANT MIXED TUMORS; SALIVARY-GLANDS; CARCINOMAS
AB Objectives: Carcinosarcoma (true malignant mixed tumor) of the parotid gland is an extremely uncommon tumor composed of both carcinomatous and sarcomatous components. An understanding of this manifestation is crucial to guide management and treatment of this disease.
   Methods: A patient who presented with facial nerve weakness and a painful mass of the parotid gland underwent fine needle aspiration, laboratory testing, and computed tomography of the neck that demonstrated a large parotid malignancy. The patient underwent surgical treatment followed by radiotherapy. Histologic and immunohistochemical examination of the specimen was performed.
   Results: This report of a slow-growing parotid mass with otalgia and facial nerve weakness was treated with radical parotidectomy, supraomohyoid neck dissection, and cable graft repair of the excised facial nerve, which was completely encircled by tumor. Postoperative radiotherapy was administered. Histologic and immunohistochemical evaluation demonstrated carcinosarcoma.
   Conclusions: Carcinosarcoma is an unusual tumor of the parotid gland. Treatment generally involves surgery with subsequent radiotherapy. Long-term close follow-up is recommended, for this tumor has a high propensity for both local and regional recurrence and metastasis.
C1 Univ Missouri, Sch Med, Dept Otolaryngol Head & Neck Surg, Columbia, MO 65212 USA.
   Univ Missouri, Sch Med, Dept Pathol & Anat Sci, Columbia, MO 65212 USA.
RP Zitsch, RP (reprint author), Univ Missouri, Sch Med, Dept Otolaryngol Head & Neck Surg, 1 Hosp Dr, Columbia, MO 65212 USA.
CR Ansari-Lari MA, 2002, AM J SURG PATHOL, V26, P1024, DOI 10.1097/01.PAS.0000018104-32686.56
   BARNES L, 2005, PATHOLOGY GENETICS H, V9, P244
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   GNEPP DR, 1993, PATHOL ANNU, V28, P279
   KIRKLIN JW, 1951, SURG GYNECOL OBSTET, V92, P721
   Latkovich P, 1998, ARCH PATHOL LAB MED, V122, P743
   Sironi M, 2000, PATHOL RES PRACT, V196, P511
   STEPHEN J, 1986, ORAL SURG ORAL MED O, V61, P597, DOI 10.1016/0030-4220(86)90102-7
   TORTOLEDO ME, 1984, ARCH OTOLARYNGOL, V110, P172
   ZITSCH RP, 2003, DSALIVARY GLAND NEOP
NR 10
TC 3
Z9 4
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD SEP
PY 2007
VL 116
IS 9
BP 702
EP 704
PN 1
PG 3
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 211RW
UT WOS:000249542000012
PM 17926594
ER

PT J
AU Ketelslagers, K
   Somers, T
   De Foer, B
   Zarowski, A
   Offeciers, E
AF Ketelslagers, Katrien
   Somers, Thomas
   De Foer, Bert
   Zarowski, Andrzej
   Offeciers, Erwin
TI Results, hearing rehabilitation, and follow-up with magnetic resonance
   imaging after tympanomastoid exenteration, obliteration, and external
   canal overclosure for severe chronic otitis media
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE auditory rehabilitation; follow-up; magnetic resonance imaging; severe
   chronic otitis media; tympanomastoid exenteration
ID RESIDUAL CHOLESTEATOMA; COCHLEAR IMPLANTATION; MIDDLE-EAR; SUBTOTAL
   PETROSECTOMY; MANAGEMENT
AB Objectives: We sought to evaluate the results, auditory rehabilitation, and follow-up with magnetic resonance imaging (MRI) after tympanomastoid exenteration with obliteration of the mastoid cavity and overclosure of the external ear canal in patients with severe chronic otitis media that was resistant to medical therapy and conventional surgery and was associated with a profound sensorineural or severe conductive hearing loss.
   Methods: Twenty-nine patients were analyzed and underwent this surgical technique. Twelve patients had, during the same or later stage, either cochlear implantation, fixture implantation for a bone-anchored hearing aid, or middle ear implantation. For follow-up control of the obliterated cavity, delayed gadolinium-enhanced, T1-weighted MRI in combination with non-echo planar imaging diffusion weighted sequences were used.
   Results: No patient had recurrent otorrhea after an average follow-up period of 4.75 years. One patient had a residual cholesteatoma as shown by new MRI techniques, and this was successfully resected. One patient developed complications 6 months after 1-stage tympanomastoid exenteration and cochlear implantation.
   Conclusions: This technique is very useful in selected patients with severe chronic otitis media that is resistant to medical therapy and surgery and is associated with a profound sensorineural or severe conductive hearing loss. New sequences in MRI are used for postoperative follow-up of these obliterated cavities and seem reliable for the detection of residual or recurrent cholesteatoma. Middle car implantation and cochlear implantation can be relatively safely performed in these patients in a second stage.
C1 Sint Augustinus Hosp, Univ Dept ENT, B-2610 Antwerp, Belgium.
   Sint Augustinus Hosp, Dept Radiol, B-2610 Antwerp, Belgium.
RP Somers, T (reprint author), Sint Augustinus Hosp, Univ Dept ENT, OOsterveldlaan 24, B-2610 Antwerp, Belgium.
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   De Foer B, 2006, AM J NEURORADIOL, V27, P1480
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   El-Kashlan HK, 2002, OTOL NEUROTOL, V23, P53, DOI 10.1097/00129492-200201000-00013
   Fisch U, 1988, MICROSURGERY SKULL B, P4
   GACEK RR, 1976, ANN OTO RHINOL LARYN, V85, P305
   Gray RF, 1999, J LARYNGOL OTOL, V113, P881
   GRAY RF, 1995, AM J OTOL, V16, P682
   Harada T, 2003, OTOL NEUROTOL, V24, P83, DOI 10.1097/00129492-200301000-00017
   Ishida K, 1997, AM J OTOL, V18, P472
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   Vercruysse JP, 2006, EUR RADIOL, V16, P1461, DOI 10.1007/s00330-006-0160-2
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NR 22
TC 2
Z9 3
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD SEP
PY 2007
VL 116
IS 9
BP 705
EP 711
PN 1
PG 7
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 211RW
UT WOS:000249542000013
PM 17926595
ER

PT J
AU Patterson, JM
   Hildreth, A
   Wilson, JA
AF Patterson, Joanne M.
   Hildreth, Anthony
   Wilson, Janet A.
TI Measuring edema in irradiated head and neck cancer patients
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT 12th British Academic Conference on Otolaryngoloyg
CY JUL 06-08, 2006
CL Birmingham, ENGLAND
DE edema; head and neck cancer; larynx; pharynx; radiotherapy; side effect.
ID RADIATION-THERAPY; RELIABILITY; TOXICITY; LARYNX
AB Objectives: Edema is a common side effect of radiotherapy for head and neck cancer. Systems have been developed to record and monitor changes that occur after radiotherapy. These lack the sensitivity to record edema in specific laryngopharyngeal structures. The aim of this study was to develop a rating scale to measure edema in the larynx and pharynx.
   Methods: This was an exploratory study to develop a new measure, with the help of an expert panel, assessing interrater and intrarater reliability. A consensus group developed the rating scale. Eleven structures and 2 spaces were identified as areas sensitive to the development of edema. The terms no, mild, moderate, and severe were used to describe the degrees of edema. The scale was piloted and then tested for interrater and intrarater reliability on 5 speech and language therapists. They viewed 25 nasendolaryngoscopic images (23 patients who had had radiotherapy and 2 healthy volunteers). The images were rated with the scale. This process was repeated 1 week later.
   Results: Images were taken from patients with oral, oropharyngeal, nasopharyngeal, or laryngeal cancer. All had had radiotherapy or chemoradiotherapy. All raters were experienced in viewing larynges via nasendolaryngoscopy. The interrater reliability for scoring the edema rating scale was moderate (weighted kappa, 0.54). Lower levels of agreement were found for the tongue base, valleculae, pharyngeal walls, and anterior commissure. The intrarater reliability was very good (weighted kappa, 0.84).
   Conclusions: The edema rating scale can be scored with very good test-retest reproducibility and moderate levels of agreement between clinicians. Modifications to the method are suggested to increase interrater reliability.
C1 Univ Newcastle, Ctr Hlth Serv Res, Dept Surg & Reprod Sci, Newcastle Upon Tyne NE2 4AA, Tyne & Wear, England.
   Sunderland Royal Hosp, Dept Res, Sunderland, Hildreth, England.
RP Patterson, JM (reprint author), Univ Newcastle, Ctr Hlth Serv Res, Dept Surg & Reprod Sci, 21 Claremont Pl, Newcastle Upon Tyne NE2 4AA, Tyne & Wear, England.
CR Belafsky PC, 2001, LARYNGOSCOPE, V111, P1313, DOI 10.1097/00005537-200108000-00001
   Branski RC, 2002, LARYNGOSCOPE, V112, P1019, DOI 10.1097/00005537-200206000-00016
   COOPER JS, 1995, INT J RADIAT ONCOL, V31, P1141, DOI 10.1016/0360-3016(94)00421-G
   COX JD, 1995, INT J RADIAT ONCOL, V31, P1341, DOI 10.1016/0360-3016(95)00060-C
   Dische S, 1994, SEMIN RADIAT ONCOL, V4, P112, DOI [10.1053/SRAO00400112, DOI 10.1053/SRAO00400112]
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   Rudat V, 1999, RADIOTHER ONCOL, V53, P233, DOI 10.1016/S0167-8140(99)00149-8
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   Streiner D, 2003, HLTH MEASUREMENT SCA
NR 14
TC 9
Z9 9
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD AUG
PY 2007
VL 116
IS 8
BP 559
EP 564
PG 6
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 203GE
UT WOS:000248962300001
PM 17847721
ER

PT J
AU Stavroulaki, P
   Skoulakis, C
   Theos, E
   Kokalis, N
   Valagianis, D
AF Stavroulaki, Pelagia
   Skoulakis, Charalampos
   Theos, Evangelos
   Kokalis, Nikolaos
   Valagianis, Dimitrios
TI Thermal welding versus cold dissection tonsillectomy: A prospective,
   randomized, single-blind study in adult patients
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE adult; morbidity; pain; thermal sealing; thermal welding; tonsillectomy
ID PAIN
AB Objectives: We performed a single-blind, prospective, randomized, controlled clinical study to compare the rates of postoperative morbidity in adults undergoing thermal.welding tonsillectomy versus cold dissection tonsillectomy.
   Methods: Thirty-two adults with recurrent tonsillitis who were scheduled for elective tonsillectomy were randomized to either thermal welding or cold dissection tonsillectomy groups. The main outcome measures included intraoperative blood loss, intensity of postoperative pain expressed on a 10-cm visual analog scale (with 0 representing no pain and 10 representing the worst possible pain), day of cessation of significant pain (ie, a pain score of at least 7), and presence of postoperative hemorrhage estimated on a 3-point scale (with 0 representing no bleeding, 1 representing minor bleeding, and 2 representing major bleeding). Additional outcome measures included total analgesic requirements, last day of receipt of analgesics, presence of nausea and/or vomiting, and wound healing after 10 days of surgery.
   Results: The rate of intraoperative blood loss was significantly lower in the thermal welding group (p < .0001). Patients who had thermal welding tonsillectomy also showed a general trend toward lower pain scores, and this difference was statistically significant from the first to the fourth postoperative days (p < .05). Cessation of significant pain also occurred 3 days earlier in this group (p < .05). No significant difference was observed regarding pain medication, nausea and/or vomiting, postoperative hemorrhage, or wound healing.
   Conclusions: Thermal welding tonsillectomy is a relatively safe and reliable method with significantly less postoperative morbidity than cold dissection tonsillectomy.
C1 Gen Hosp Volos, Dept Otorhinolaryngol, Volos, Greece.
RP Stavroulaki, P (reprint author), 34 Kassaveti Str, Volos 38221, Greece.
CR ALTMAN DG, 1980, BRIT MED J, V281, P1336
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   FREEMAN SB, 1992, LARYNGOSCOPE, V102, P1242, DOI 10.1288/00005537-199211000-00007
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   Huskisson E, 1983, PAIN MEASUREMENT ASS, P33
   Karatzias GT, 2006, OTOLARYNG HEAD NECK, V134, P975, DOI 10.1016/j.otohns.2006.03.003
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   LEACH J, 1993, LARYNGOSCOPE, V103, P619
   Leinbach RF, 2003, OTOLARYNG HEAD NECK, V129, P360, DOI 10.1016/S0194-5998(03)00729-0
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   RAMSDEN R, 2004, INTERIM REPORT CHAIR
   Treat MR, NEW THERMAL DEVICE S
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NR 15
TC 12
Z9 12
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD AUG
PY 2007
VL 116
IS 8
BP 565
EP 570
PG 6
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 203GE
UT WOS:000248962300002
PM 17847722
ER

PT J
AU Mitzrier, R
   Brodsky, L
AF Mitzrier, Ron
   Brodsky, Linda
TI Multilevel esophageal biopsy in children with airway manifestations of
   extraesophageal reflux disease
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT 86th Annual Meeting of the American-Broncho-Esophagological-Association
CY MAY 19-20, 2006
CL Chicago, IL
SP Amer Broncho Esophagol Assoc
DE esophagoscopy; extraesophageal reflux disease; gastroesophageal reflux;
   multilevel esophageal biopsy
ID GASTROESOPHAGEAL-REFLUX; ADENOCARCINOMA; LARYNGOSCOPY; ENDOSCOPY; RISK
AB Objectives: Extraesophageal reflux disease (EERD) is a recognized cause of upper airway symptoms in children. Direct microlaryngoscopy and bronchoscopy (MLB) is performed for diagnostic information as to the extent and severity of the inflammation caused by gastric refluxate. Esophagoscopy with multilevel biopsy performed at the time of MLB may provide the clinician with additional information to assist in the management of EERD. We undertook to determine the role of multilevel esophageal biopsy in children who have airway manifestations secondary to EERD.
   Methods: We performed a retrospective chart review of 139 esophagoscopies with multilevel biopsy done at the time of MLB by a single provider for evaluation of symptoms highly associated with EERD at a tertiary care children's hospital. The histopathologic presence of esophagitis was analyzed by site and compared to the presence and location of tracheo-laryngeal abnormalities.
   Results: Tracheolaryngeal abnormalities associated with EERD were found in 97% of patients when evaluated by MLB. Concomitant esophagitis was found in 59% of these patients. Of patients who had 0, 1, 2, 3, 4, or 5 positive findings on MLB, 75% (3 of 4), 58% (7 of 12), 57% (20 of 35),62% (32 of 51),56% (18 of 32), and 80% (4 of 5), respectively, had at least I positive biopsy.
   Conclusions: We found that EERD that affects the pediatric upper airway was associated with esophagitis in more than half of the patients. The usefulness of 4-level biopsies during esophagoscopy and concomitant airway endoscopy will be discussed.
C1 SUNY Buffalo, Sch Med & Biomed Sci, Dept Otolaryngol, Buffalo, NY 14260 USA.
   SUNY Buffalo, Sch Med & Biomed Sci, Dept Pediat, Buffalo, NY 14260 USA.
RP Brodsky, L (reprint author), 651 Delaware Ave, Buffalo, NY 14202 USA.
CR Brodsky Linda, 2006, Curr Opin Otolaryngol Head Neck Surg, V14, P387, DOI 10.1097/MOO.0b013e3280106326
   Carr MM, 2000, INT J PEDIATR OTORHI, V54, P27, DOI 10.1016/S0165-5876(00)00339-6
   Carr MM, 2001, ARCH OTOLARYNGOL, V127, P369
   Eubanks TR, 2001, J GASTROINTEST SURG, V5, P183, DOI 10.1016/S1091-255X(01)80032-9
   FRYCKMAN PK, 2003, OPERATIVE PEDIAT SUR, P374
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   Lagergren J, 1999, NEW ENGL J MED, V340, P825, DOI 10.1056/NEJM199903183401101
   Mandell DL, 2004, ARCH OTOLARYNGOL, V130, P1293, DOI 10.1001/archotol.130.11.1293
   McMurray JC, 2001, ANN OTO RHINOL LARYN, V110, P299
   Pohl H, 2005, J NATL CANCER I, V97, P142, DOI 10.1093/jnci/dji024
   Reavis KM, 2004, ANN SURG, V239, P849, DOI 10.1097/01.sla.0000128303.05898.ee
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NR 13
TC 5
Z9 6
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD AUG
PY 2007
VL 116
IS 8
BP 571
EP 575
PG 5
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 203GE
UT WOS:000248962300003
PM 17847723
ER

PT J
AU Xu, W
   Han, D
   Hou, L
   Zhang, L
   Zhao, GW
AF Xu, Wen
   Han, Demin
   Hou, Lizhen
   Zhang, Li
   Zhao, Gongwei
TI Value of laryngeal electromyography in diagnosis of vocal fold
   immobility
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE electromyography; vocal fold immobility
ID PARALYSIS; SYNKINESIS; PARESIS
AB Objectives: We sought to determine the value of laryngeal electromyography (LEMG) and evoked LEMG in the diagnosis of vocal fold immobility.
   Methods: We analyzed 110 cases of vocal fold immobility by their clinical manifestations and LEMG characteristics, including spontaneous potential activity, motor unit potential measurement, recruitment pattern analysis, and evoked LEMG signals.
   Results: With LEMG, we identified 87 patients with neuropathic laryngeal injuries. Neurogenic vocal fold immobility showed a wide variety of abnormal activity. Fibrillation potentials and positive sharp waves were found in patients with laryngeal nerve injuries. For laryngeal paralysis, there was no reaction with LEMG and evoked LEMG. For incomplete laryngeal paralysis, decreased evoked LEMG signals were also seen with delayed latency (thyroarytenoid muscle, 2.2 +/- 1.0 ms, p < .0 1; posterior cricoarytenoid muscle, 2.4 +/- 1.0 ms, p < .05) and lower amplitude (thyroarytenoid muscle, 0.9 +/- 0.7 mV, p < .05; posterior cricoarytenoid muscle, 1.2 +/- 1.0 mV, p < .01). Nineteen patients with vocal fold mechanical limitations generally had normal LEMG and evoked LEMG signals. Four patients with neoplastic infiltration of the laryngeal muscles demonstrated abnormal LEMG signals but nearly normal evoked LEMG signals.
   Conclusions: We conclude that LEMG and evoked LEMG behavior plays a crucial role in the diagnosis of vocal fold immobility. The decreased recruitment activities on LEMG and the decreased evoked LEMG signals with longer latency and lower amplitude reflect the severity of neuropathic laryngeal injury.
C1 Capital Med Univ, Beijing Tongren Hosp, Dept Otorhinolaryngol Head & Neck Surg, Beijing, Peoples R China.
RP Han, D (reprint author), Beijing Tongren Hosp, Dept Otorhinolaryngol Head & Neck Surg, 1 Dongjiaominxiang St, Beijing 100730, Peoples R China.
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   Maronian NC, 2004, ANN OTO RHINOL LARYN, V113, P877
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NR 16
TC 17
Z9 17
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
EI 1943-572X
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD AUG
PY 2007
VL 116
IS 8
BP 576
EP 581
PG 6
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 203GE
UT WOS:000248962300004
PM 17847724
ER

PT J
AU Cunningham, JJ
   Halum, SL
   Butler, SG
   Postma, GN
AF Cunningham, Jeffrey J.
   Halum, Stacey L.
   Butler, Susan G.
   Postma, Gregory N.
TI Intraobserver and Interobserver reliability in laryngopharyngeal sensory
   discrimination thresholds: A pilot study
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT 86th Annual Meeting of the American-Broncho-Esophagological-Association
CY MAY 19-20, 2006
CL Chicago, IL
SP Amer Broncho Esophagol Assoc
DE adductor reflex; larynx; sensory testing; swallowing
ID LARYNGEAL ADDUCTOR REFLEX; ENDOSCOPIC EVALUATION; PHARYNGEAL; STROKE
AB Objectives: Laryngopharyngeal sensory discrimination threshold (LPSDT) testing is a method used to detect sensory deficits in patients in whom swallowing disorders are suspected. LPSDTs have been used to stratify patient risk status with regard to aspiration and to guide dietary management. The aim of this pilot study was to evaluate the intraobserver and interobserver reliability of LPSDT testing among a group of examiners with differing levels of testing experience.
   Methods: Twenty-seven healthy volunteers were enrolled in the study to elicit LPSDTs for intraobserver and interobserver reliability measurements. The examiners represented 3 levels of testing experience: an attending laryngologist, a laryngology fellow, and an otolaryngology resident. With the examiners blinded to test results, each subject was examined twice by one examiner and once by a different examiner in an alternating fashion.
   Results: Six subjects were unable to tolerate the examinations because of coughing and gagging. Spearman rank correlations revealed strong intraobserver reliability for the experienced endoscopists (ie, attending and fellow) but poor reliability for the novice endoscopist (ie, resident). Poor interobserver reliability regardless of endoscopy experience was found. Eighteen percent of the participants demonstrated LPSDTs of more than 4.0 mm Hg (above normal).
   Conclusions: 1) Intraobserver reliability was good for experienced endoscopists. 2) Interobserver LPSDT agreement between endoscopists was poor. 3) Eighteen percent of the subjects demonstrated elevated LPSDT thresholds of more than 4 mm Hg.
C1 Wake Forest Univ, Baptist Med Ctr, Ctr Voice Swallowing Disorders, Dept Otolaryngol, Winston Salem, NC 27109 USA.
RP Postma, GN (reprint author), Med Coll Georgia, Ctr Voice & Swallowing Disorders, Dept Otolaryngol, Augusta, GA 30912 USA.
CR Aviv J E, 1998, Ann Otol Rhinol Laryngol, V107, P378
   Aviv JE, 1999, ANN OTO RHINOL LARYN, V108, P725
   Aviv Jonathan E., 1993, Annals of Otology Rhinology and Laryngology, V102, P777
   MARTIN JH, 1994, ANN OTO RHINOL LARYN, V103, P749
   Aviv JE, 2000, DYSPHAGIA, V15, P39
   Aviv JE, 2002, LARYNGOSCOPE, V112, P338, DOI 10.1097/00005537-200202000-00025
   Aviv JE, 1997, ANN OTO RHINOL LARYN, V106, P87
   Aviv JE, 1996, ANN OTO RHINOL LARYN, V105, P92
   Hiss SG, 2003, LARYNGOSCOPE, V113, P1386, DOI 10.1097/00005537-200308000-00023
   Kearney PR, 2005, ANN OTO RHINOL LARYN, V114, P264
   Langmore S E, 1988, Dysphagia, V2, P216, DOI 10.1007/BF02414429
   Singh V, 1997, J LARYNGOL OTOL, V111, P616
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NR 13
TC 3
Z9 3
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD AUG
PY 2007
VL 116
IS 8
BP 582
EP 588
PG 7
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 203GE
UT WOS:000248962300005
PM 17847725
ER

PT J
AU Cole, SM
   Patterson, MB
   Cupp, CL
AF Cole, Stephanie M.
   Patterson, Matthew B.
   Cupp, Craig L.
TI Tonsillectomy in the anticoagulated patient
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE anticoagulation; antiphospholipid syndrome; perioperative management;
   tonsillectomy.
ID MOLECULAR-WEIGHT HEPARIN; 7TH ACCP CONFERENCE; THROMBOLYTIC THERAPY;
   MANAGEMENT; SURGERY; ADENOIDECTOMY; INTERRUPTION; THROMBOSIS;
   HEMORRHAGE; DISEASE
AB Objectives: The objectives of this study were to review perioperative bridging strategies for anticoagulated patients and to describe a novel bridging strategy for tonsillectomy in an anticoagulated patient that addresses both primary and secondary hemorrhage risks.
   Methods: A literature review and a case report are presented. PubMed was reviewed for evidence-based recommendations on perioperative management of anticoagulated patients. A case report is detailed of a 28-year-old woman with antiphospholipid syndrome on warfarin for high risk of venous thrombosis who underwent tonsillectomy. A perioperative bridging strategy incorporating outpatient low-molecular weight heparin and inpatient unfractionated heparin was implemented to minimize risks of thrombosis and primary and secondary posttonsillectomy hemorrhage.
   Results: Limited evidence supports a consensus on the best perioperative management of anticoagulated patients. Tonsillectomy in an anticoagulated patient has not been described previously. The patient in this case underwent successful tonsillectomy with no thrombosis or bleeding after I month of follow-up.
   Conclusions: Tonsillectomy can be done relatively safely in an anticoagulated patient at high risk for thrombosis. The perioperative bridging strategy should account for its unique risk of primary and secondary postoperative hemorrhage. A proposed algorithm for managing these competing risks is presented.
C1 USN, Med Ctr, Dept Otolaryngol, San Diego, CA 92134 USA.
RP Cupp, CL (reprint author), USN, Med Ctr, Dept Otolaryngol, 34800 Bob Wilson Dr,Suite 200, San Diego, CA 92134 USA.
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   Douketis JD, 2004, ARCH INTERN MED, V164, P1319, DOI 10.1001/archinte.164.12.1319
   Guyatt G, 2004, CHEST, V126, p179S, DOI 10.1378/chest.126.3_suppl.179S
   Hirsh J, 2004, CHEST, V126, p188S, DOI 10.1378/chest.126.3_suppl.188S
   Jimenez-Yuste V, 2002, ARCH OTOLARYNGOL, V128, P1365
   Kearon C, 1997, NEW ENGL J MED, V336, P1506, DOI 10.1056/NEJM199705223362107
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NR 21
TC 1
Z9 1
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD AUG
PY 2007
VL 116
IS 8
BP 589
EP 593
PG 5
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 203GE
UT WOS:000248962300006
PM 17847726
ER

PT J
AU Olthoff, A
   Laskawi, R
   Kruse, E
AF Olthoff, Arno
   Laskawi, Rainer
   Kruse, Eberhard
TI Successful treatment of autophonia with botulinum toxin: Case report
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE autophonia; botulinum toxin; impedance audiometry; patulous eustachian
   tube; tensor veli palatini muscle; tinnitus
ID PATULOUS EUSTACHIAN-TUBE; TENSOR VELI PALATINI; MUSCLES; PARALYSIS;
   ANATOMY
AB Objectives: We sought to treat autophonia due to a patulous eustachian tube using botulinum toxin.
   Methods: Because we assumed that the patulous eustachian tube was caused by abnormal activity of paratubal muscles (tensor and levator veli palatini muscles and salpingopharyngeus muscle), paralysis was performed via injection of botulinum toxin type A in a 45-year-old female professional musician who had had chronic unilateral autophonia for 20 years. In addition to a patient interview, an endoscopic examination of the nasopharynx (posterior rhinoscopy), ear microscopy, and impedance audiometry were performed to verify the diagnosis and the outcome after treatment.
   Results: The autophonia disappeared 1 week after treatment. Normalized tympanic ventilation was verified by impedance audiometry after 8 weeks. The period of symptom relief was 9 months.
   Conclusions: The administration of botulinum toxin type A provides a new option in the treatment of patulous eustachian tube. The reliability of this method and the effect of repeated injections remains to be proved in future studies.
C1 Univ Gottingen, Dept Phoniatr & Pedaudiol, D-37035 Gottingen, Germany.
   Univ Gottingen, Dept Otorhinolaryngol, D-3400 Gottingen, Germany.
RP Olthoff, A (reprint author), Univ Gottingen, Dept Phoniatr & Pedaudiol, Robert Koch Str 40, D-37035 Gottingen, Germany.
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NR 25
TC 7
Z9 8
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD AUG
PY 2007
VL 116
IS 8
BP 594
EP 598
PG 5
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 203GE
UT WOS:000248962300007
PM 17847727
ER

PT J
AU Woo, JS
   Kim, KM
   Kang, JS
   Zodpe, P
   Chae, SW
   Hwang, SJ
   Lee, HM
AF Woo, Jeong-Soo
   Kim, Kyoung-Min
   Kang, Jae Seong
   Zodpe, Prakash
   Chae, Sung-Won
   Hwang, Soon-Jae
   Lee, Heung-Man
TI Expression of neutrophil gelatinase-associated lipocalin in human
   salivary glands
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE neutrophil gelatinase-associated lipocalin; sialadenitis
ID EPITHELIAL-CELLS; PROTEIN; GRANULES; IDENTIFICATION; PEPTIDES; PATTERN;
   NGAL
AB Objectives: We performed an observational study of RNA and protein expression in human tissue to examine the distribution of neutrophil gelatinase-associated lipocalin (NGAL) in normal and chronic inflammatory salivary tissues, and to investigate the expression level of NGAL in inflammatory conditions of salivary glands.
   Methods: Normal salivary gland tissues and tissue samples of salivary glands with chronic sialadenitis were obtained. Expression of NGAL was investigated by reverse transcriptase-polymerase chain reaction, and semiquantitative analysis of these results was also performed. The differential localization and amount of immunoreactivity to NGAL protein was evaluated by immunohistochemistry and Western blot analysis in normal salivary gland tissues and salivary glands with chronic sialadenitis.
   Results: NGAL messenger RNA transcripts were detected in the tissues from the salivary glands with chronic sialadenitis, but only a small amount was detected in the tissues from the normal salivary glands. A weak expression of NGAL protein was occasionally seen in a few ductal epithelial cells of normal salivary gland tissue. However, in tissue samples from glands with chronic sialadenitis, the NGAL protein was expressed strongly in ductal epithelial cells and infiltrating inflammatory cells.
   Conclusions: These results imply that NGAL is associated with the regulation of inflammation in salivary glands.
C1 Korea Univ, Coll Med, Guro Hosp, Dept Otorhinolaryngol Head & Neck Surg, Seoul 152703, South Korea.
   Korea Univ, Coll Med, Div Brain Korea 21 Program Biomed Sci, Seoul 136701, South Korea.
RP Lee, HM (reprint author), Korea Univ, Coll Med, Guro Hosp, Dept Otorhinolaryngol Head & Neck Surg, 80 Guro Dong, Seoul 152703, South Korea.
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NR 11
TC 1
Z9 3
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD AUG
PY 2007
VL 116
IS 8
BP 599
EP 603
PG 5
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 203GE
UT WOS:000248962300008
PM 17847728
ER

PT J
AU Mu, L
   Sanders, I
AF Mu, Liancai
   Sanders, Ira
TI Neuromuscular specializations within human pharyngeal constrictor
   muscles
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT 87th Annual Meeting of the American-Broncho-Esophagological-Association
CY APR 26-27, 2007
CL San Diego, CA
SP Amer Broncho Esophagol Assoc
DE electrophoretic immunoblotting; fiber type; glossopharyngeal nerve;
   immunocytochemistry; motor innervation; muscle fiber layer; myosin heavy
   chain expression; pharyngeal constrictor muscle; vagus nerve.
ID HUMAN CRICOPHARYNGEUS MUSCLE; UPPER ESOPHAGEAL SPHINCTER; FIBER-TYPE
   REGIONALIZATION; CAT LATERAL GASTROCNEMIUS; HUMAN MYLOHYOID MUSCLE;
   HEAVY-CHAIN ISOFORMS; GLOSSOPHARYNGEAL NERVE; PARKINSONS-DISEASE; SPEECH
   PRODUCTION; SLEEP-APNEA
AB Objectives: At present it is believed that the pharyngeal constrictor (PC) muscles are innervated by the vagus (X) nerve and are homogeneous in muscle fiber content. This study tested the hypothesis that adult human PCs are divided into 2 distinct and specialized layers: a slow inner layer (SIL), innervated by the glossopharyngeal (IX) nerve, and a fast outer layer (FOL), innervated by nerve X.
   Methods: Eight normal adult human pharynges (16 sides) obtained from autopsies were studied to determine 1) their gross motor innervation by use of Sihler's stain; 2) their terminal axonal branching by use of acetyleholinesterase (AChE) and silver stain; and 3) their myosin heavy chain (MHC) expression in PC muscle fibers by use of immunocytochemical and immunoblotting techniques. In addition, the specialized nature of the 2 PC layers was also studied in developmental (newborn, neonate, and senescent humans), pathological (adult humans with idiopathic Parkinson's disease [IPD]), and comparative (nonhuman primate [adult macaque monkey]) specimens.
   Results: When nerves IX and X were traced from their cranial roots to their intramuscular termination in Sihler's-stained specimens, it was seen that nerve IX supplied the SIL, whereas branches of nerve X innervated the FOL in the adult human. PCs. Use of AChE and silver stain confirmed that nerve IX branches supplying the SIL contained motor axons and innervated motor end plates'. In addition to distinct motor innervation, the SIL contained muscle fibers expressing slow-tonic and a-cardiac MHC isoforms, whereas the FOL contained muscle fibers expressing developmental MHC isoforms. In contrast, the FOL became obscured in the elderly and in the adult humans with IPD because of an increased proportion of slow muscle fibers. Notably, distinct muscle fiber layers were not found in the human newborn and nonhuman primate (monkey), but were identified in the 2-year-old human.
   Conclusions: Human PCs appear to be organized into functional fiber layers, as indicated by distinct motor innervation and specialized muscle fibers. The SIL appears to be a specialized layer unique to normal humans. The presence of the highly specialized slow-tonic and a-cardiac MHC isoforms, together with their absence in human newborns and nonhuman primates, suggests that the specialization of the SIL may. be related to speech and respiration. This specialization may reflect the sustained contraction needed in humans to maintain stiffness of the pharyngeal walls during respiration and to shape the walls for speech articulation. In contrast, the FOL is adapted for rapid movement as seen during swallowing. Senescent humans and patients with IPD are known to be susceptible to dysphagia; and this susceptibility may be related to the observed shift in muscle fiber content.
C1 Mt Sinai Sch Med, Dept Otolaryngol, Upper Airway Res Lab, New York, NY 10029 USA.
   Hackensack Univ Med Ctr, Alice & David Jurist Inst Biomed Res, Hackensack, NJ USA.
RP Mu, L (reprint author), Mt Sinai Sch Med, Dept Otolaryngol, Upper Airway Res Lab, New York, NY 10029 USA.
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NR 50
TC 16
Z9 17
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD AUG
PY 2007
VL 116
IS 8
BP 604
EP 617
PG 14
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 203GE
UT WOS:000248962300009
PM 17847729
ER

PT J
AU Abdelkafy, WM
   Smith, JQ
   Henriquez, OA
   Golub, JS
   Xu, J
   Rojas, M
   Brigham, KL
   Johns, MM
AF Abdelkafy, Wael M.
   Smith, Johnathon Q.
   Henriquez, Oswaldo A.
   Golub, Justin S.
   Xu, Jianguo
   Rojas, Mauricio
   Brigham, Kenneth L.
   Johns, Michael M.
TI Age-related changes in the murine larynx: Initial validation of a mouse
   model
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT 87th Annual Meeting of the American-Broncho-Esophagological-Association
CY APR 26-27, 2007
CL San Diego, CA
SP Amer Broncho Esophagol Assoc
DE aging; larynx; mouse; vocal fold
ID HUMAN VOCAL FOLD; GROWTH-FACTOR; VOICE
AB Objectives: Changes in voice are commonly associated with aging (presbyphonia). Age-related voice change significantly impairs elderly individuals' ability to communicate meaningfully with others and affects their quality of life. With changing age demographics in our society and increasing emphasis on quality of life, treatment of presbylaryngis is becoming more paramount.
   Methods: We used 9 aged and 9 young mice to validate a mouse model for the aging larynx. We stained the larynges with Alcian blue to determine the hyaluronic acid content, trichrome stain to determine the collagen content, and immunohistochemical stain for alpha smooth muscle actin to determine the myofibroblast content. Morphometric measurements were performed for muscle area, muscle thickness, and muscle fiber diameter.
   Results: Statistically significant differences in the density measurements of hyaluronic acid and collagen reflected dec, creased hyaluronic acid and increased collagen content in the aging larynx. We found cc smooth muscle actin-labeled myofibroblasts only in the aged larynges. No statistically significant differences were found in the morphometric measurements.
   Conclusions: Aged mice may make a practical model for the age-related changes in the vocal folds that can be used further in studies aiming to correct these changes.
C1 Emory Univ, Sch Med, Emory Voice Ctr, Dept Otorhinolaryngol Head & Neck Surg, Atlanta, GA 30322 USA.
   Emory Univ, Sch Med, Ctr Translat Res Lung, Div Pulm Allergy & Crit Care,Dept Med, Atlanta, GA 30322 USA.
RP Johns, MM (reprint author), Emory Crawford Long Hosp, Emory Voice Ctr, Med Off Tower,9th Floor,550 Peachtree St, Atlanta, GA 30308 USA.
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NR 17
TC 16
Z9 19
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD AUG
PY 2007
VL 116
IS 8
BP 618
EP 622
PG 5
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 203GE
UT WOS:000248962300010
PM 17847730
ER

PT J
AU Hydman, J
   Remahl, S
   Bjoerck, G
   Svensson, M
   Mattsson, P
AF Hydman, Jonas
   Remahl, Sten
   Bjoerck, Gunnar
   Svensson, Mikael
   Mattsson, Per
TI Nimodipine improves reinnervation and neuromuscular function after
   injury to the recurrent laryngeal nerve in the rat
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE electrophysiology; misdirected reinnervation; motor end plate;
   peripheral nerve injury; regeneration
ID CALCIUM TRANSIENTS; FACIAL-NERVE; RECOVERY; REGENERATION; MUSCLES;
   CHANNEL; DENERVATION; RESECTION; NEURONS; DAMAGE
AB Objectives: Injury of the recurrent laryngeal nerve (RLN) is associated with a high degree of neuronal survival, but leads to various levels of vocal fold motion impairment or laryngeal synkinesis, which has been attributed to misdirected reinnervation of the target muscles in the larynx or aberrant, competing reinnervation from adjacent nerve fibers. The aim of the present study was to evaluate the impact of the regeneration-promoting agent nimodipine on reinnervation and neuromuscular function following RLN crush injury.
   Methods: Sixty adult rats were randomized into nimodipine-treated or untreated groups and then underwent RLN crush injury. Reinnervation of the posterior cricoarytenoid muscle (PCA) was assessed by electrophysiological examination, retrograde tracing of lower motor neurons before and after injury, and quantification of neuromuscular junctions in the PCA muscle.
   Results: At 6 weeks after injury, the nimodipine-treated animals showed significantly enhanced neuromuscular function and also demonstrated a higher number of motor neurons in the brain stem that had reinnervated the PCA, compared to the untreated animals. The somatotopic organization of ambiguus motor neurons innervating the larynx was similar before injury and after reinnervation.
   Conclusions: Nimodipine improves regeneration and neuromuscular function following RLN injury in the adult rat, and could be of use in future strategies following RLN injury.
C1 Karolinska Inst, Dept Clin Neurosci, Div Neurosurg, S-10401 Stockholm, Sweden.
   Karolinska Inst, Dept Clin Neurosci, Div Neurophysiol, S-10401 Stockholm, Sweden.
RP Hydman, J (reprint author), Karolinska Univ Hosp, Dept Clin Neurosci, Neurosurg Sect R2 02, S-17176 Stockholm, Sweden.
RI Svensson, Mikael/F-8662-2012
OI Svensson, Mikael/0000-0003-1179-7003
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NR 28
TC 22
Z9 22
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD AUG
PY 2007
VL 116
IS 8
BP 623
EP 630
PG 8
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 203GE
UT WOS:000248962300011
PM 17847731
ER

PT J
AU Fujimoto, C
   Ito, K
   Ishimoto, SI
   Iwasaki, S
AF Fujimoto, Chisato
   Ito, Ken
   Ishimoto, Shin-Ichi
   Iwasaki, Shinichi
TI Large jugular bulb diverticulum invading the internal auditory canal
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE inferior vestibular nerve; internal auditory canal; jugular bulb
   diverticulum; vestibular evoked myogenic potential
ID ENDOLYMPHATIC DUCT OBSTRUCTION; TEMPORAL BONE; CT
AB Objectives: We report, with neuro-otologic findings, a very rare case of a large jugular bulb diverticulum eroding the internal auditory canal (IAC).
   Methods: We present the imaging and functional studies of a 29-year-old woman in whom a large jugular bulb diverticuturn on the left side was found incidentally.
   Results: Imaging studies revealed a normal external auditory canal, middle ear, and inner ear, but a large jugular bulb diverticulum extending superiorly on the left side had eroded the IAC from below and behind with destruction of the petrous bone. Caloric responses and facial movements were normal. Vestibular evoked myogenic potentials with bone conduction stimuli were absent on the left, indicating dysfunction of the left inferior vestibular system.
   Conclusions: This is the first report in the English-language literature of detailed imaging and functional findings in a very large diverticulum invading the IAC. Vestibular evoked myogenic potentials were useful in uncovering subclinical inferior vestibular system dysfunction in the jugular bulb diverticulum invading the IAC.
C1 Univ Tokyo, Fac Med, Dept Otolaryngol, Bunkyo Ku, Tokyo 1138655, Japan.
RP Ito, K (reprint author), Univ Tokyo, Fac Med, Dept Otolaryngol, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1138655, Japan.
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NR 21
TC 1
Z9 1
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD AUG
PY 2007
VL 116
IS 8
BP 631
EP 636
PG 6
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 203GE
UT WOS:000248962300012
PM 17847732
ER

PT J
AU Woodson, G
   Weiss, T
AF Woodson, Gayle
   Weiss, Todd
TI Arytenoid abduction for dynamic rehabilitation of bilateral laryngeal
   paralysis
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE bilateral paralysis; larynx; rehabilitation; surgery
ID VOCAL CORD PARALYSIS; TRANSVERSE CORDOTOMY; RECURRENT LARYNGEAL; NERVE
   INJURY; REINNERVATION; MANAGEMENT; CONFIGURATION; ADDUCTION; GLOTTIS;
   MOTION
AB Objectives: Bilateral laryngeal paralysis results in airway obstruction, but the voice is often nearly normal. Tracheotomy provides an airway and preserves voice. Surgical procedures to statically enlarge the glottis can permit decannulation, but do so at the expense of the voice. Motion analysis in cadaver larynges has demonstrated that adductor and abductor muscles rotate the arytenoid cartilage around different axes. We sought to determine whether external rotation of the arytenoid cartilage could enlarge the airway without abolishing residual phonatory adduction.
   Methods: We performed arytenoid abduction in 6 patients with obstructing laryngeal paralysis. A suture was placed in the muscular process and posterior-inferior traction was applied, anchoring the suture to the inferior cornu of the thyroid cartilage. Outcomes were evaluated by assessing airway symptoms, by assessing the voice, and by documentation of laryngeal motion via videolaryngoscopy.
   Results: Three patients with severe stridor had marked relief of symptoms, and 2 of the 3 tracheotomy-dependent patients were decannulated. Three patients had good voices, 2 had mild breathiness, and 1 was very breathy.
   Conclusions: Arytenoid abduction is a promising treatment for relieving airway obstruction in patients with laryngeal paralysis. It has the potential to preserve voice in patients with residual phonatory adduction.
C1 So Illinois Univ, Sch Med, Div Otolaryngol, Springfield, IL 62794 USA.
RP Woodson, G (reprint author), So Illinois Univ, Sch Med, Div Otolaryngol, PO Box 19662, Springfield, IL 62794 USA.
CR Bosley B, 2005, ANN OTO RHINOL LARYN, V114, P922
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NR 21
TC 6
Z9 7
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD JUL
PY 2007
VL 116
IS 7
BP 483
EP 490
PG 8
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 192AZ
UT WOS:000248174400002
PM 17727078
ER

PT J
AU Wasan, A
   Fernandez, E
   Jamison, RN
   Bhattacharyya, N
AF Wasan, Ajay
   Fernandez, Ephrem
   Jamison, Robert N.
   Bhattacharyya, Neil
TI Association of anxiety and depression with reported disease severity in
   patients undergoing evaluation for chronic rhinosinusitis
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE anxiety; chronic rhinosinusitis; depression
ID MUSCULOSKELETAL PAIN; DISABILITY; DISTRESS; SURGERY
AB Objectives: We sought to determine the impact of psychiatric comorbidity on symptom density and resource utilization in chronic rhinosinusitis (CRS).
   Methods: A prospective cohort of patients who sought evaluation of CRS was studied with the Rhinosinusitis Symptom Inventory and the Hospital Anxiety and Depression Scale. Data concerning symptom scores, symptom domains, and psychiatric comorbidity were analyzed to determine the interactions among psychiatric comorbidity, symptom reporting, and resource utilization in CRS.
   Results: We studied 143 patients (mean age, 43.4 years). Low, moderate, and high levels of anxiety were reported by 48.3%, 25.9%, and 25.9% of patients, respectively. Low, moderate, and high levels of depression were reported by 76.2%, 9.1%, and 14.7%. For the combined psychopathology group, 43.3%, 25.9%, and 30% had low, moderate, and high levels. Patients with high anxiety levels reported significant elevations of oropharyngeal symptoms (p = .013) and total symptoms (p = .030) in comparison with the low group. Patients with high depression levels reported higher oropharyngeal (p = .003), systemic (p = .001), and total symptom (p = .003) scores than did the low group. High combined psychopathology scores were associated with elevated facial, oropharyngeal, and systemic scores (p < .05). Regarding medical utilization, high anxiety levels or high combined psychopathology scores were associated with more frequent physician visits (p < .05). A high level of depression was associated with increased antibiotic use, missed workdays, and physician visits (p < .05).
   Conclusions: High levels of anxiety and depression are common in patients who undergo evaluation for CRS. Psychiatric comorbidity is associated with increased symptoms in CRS and increased health-care utilization. Anxiety and depression should be identified in these patients to structure appropriate treatment.
C1 Harvard Univ, Sch Med, Pain Management Ctr, Dept Anesthesia, Boston, MA USA.
   Harvard Univ, Sch Med, Pain Management Ctr, Dept Psychiat, Boston, MA USA.
   Harvard Univ, Sch Med, Brigham & Womens Hosp, Div Otolaryngol, Boston, MA USA.
   Harvard Univ, Sch Med, Dept Anesthesia, Boston, MA 02115 USA.
   Harvard Univ, Sch Med, Dept Psychiat, Boston, MA 02115 USA.
   Harvard Univ, Sch Med, Dept Otol & Laryngol, Boston, MA 02115 USA.
   Univ Texas, Dept Psychol, San Antonio, TX 78285 USA.
RP Bhattacharyya, N (reprint author), Div Otolaryngol, 45 Francis St, Boston, MA 02115 USA.
CR BENSON RH, 1995, PALEOCEANOGRAPHY, V10, P1, DOI 10.1029/94PA02581
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NR 17
TC 17
Z9 17
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD JUL
PY 2007
VL 116
IS 7
BP 491
EP 497
PG 7
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 192AZ
UT WOS:000248174400003
PM 17727079
ER

PT J
AU Mueller, CA
   Khatib, S
   Temmel, AFP
   Baumgartner, WD
   Hummel, T
AF Mueller, Christian A.
   Khatib, Saher
   Temmel, Andreas F. P.
   Baumgartner, Wolf-Dieter
   Hummel, Thomas
TI Effects of cochlear implantation on gustatory function
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE clinical test; cochlear implantation; gustation; taste
ID MIDDLE-EAR SURGERY; CHORDA TYMPANI NERVE; TASTE FUNCTION; RECOVERY;
   CHILDREN; COMPLICATIONS; ADULTS
AB Objectives: Because of the anatomic position of the chorda tympani in the tympanic cavity, the nerve is at risk during cochlear implantation. The aim of this study was to assess changes in taste sensitivity and in self-ratings of gustatory function after surgery.
   Methods: Twenty-four patients (mean age, 54 years) who underwent cochlear implantation were investigated. Taste function was tested with a validated test for regional quantitative assessment of sweet, sour, salty, and bitter tastes on each side of the tongue before and 4 days after surgery.
   Results: The mean taste score was 10.0 (SD, 4.0) before and 8.0 (SD, 4.1) after surgery on the side of the tongue ipsilateral to the operated ear (p = .004). However, only I patient reported subjective taste loss due to surgery. Taste testing of the side of the tongue contralateral to the operated ear yielded a score of 10.0 (SD, 4.1) before and 10.9 (SD, 4.5) after surgery (p = .037). Self-ratings of gustatory function did not change significantly as a consequence of the procedure.
   Conclusions: Our results indicate that cochlear implantation is a relatively safe procedure regarding taste function. Preoperative testing of gustatory function is recommended, at least in those patients who already have undergone operation on the contralateral ear.
C1 Med Univ Vienna, Dept Otorhinolaryngol, Gen Hosp Vienna, Vienna, Austria.
   Univ Dresden, Sch Med, Dept Otorhinolaryngol, Smell & Taste Clin, Dresden, Germany.
RP Mueller, CA (reprint author), Med Univ Vienna, AKH Wien, Dept Otorhinolaryngol, Waehringer Guertel 18-20, A-1090 Vienna, Austria.
CR Arnoldner C, 2005, ACTA OTO-LARYNGOL, V125, P228, DOI 10.1080/00016480410022895
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NR 17
TC 7
Z9 7
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD JUL
PY 2007
VL 116
IS 7
BP 498
EP 501
PG 4
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 192AZ
UT WOS:000248174400004
PM 17727080
ER

PT J
AU Bowman, J
   Panizza, B
   Gandhi, M
AF Bowman, James
   Panizza, Benedict
   Gandhi, Mitesh
TI Sphenoid sinus fungal balls
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE fungal ball; sphenoid sinus
ID PARANASAL SINUSES; RHINOSINUSITIS; DIAGNOSIS; EROSION
AB Objectives: We sought to examine the nature of fungal balls of the sphenoid sinus, in particular the exposure of adjacent skull base structures and the potential for surgical morbidity.
   Methods: We retrospectively reviewed our series of 17 cases of sphenoid sinus fungal balls seen between 1998 and 2005 with reference to their diagnosis, radiologic changes, histopathology, and surgical management.
   Results: Exposed structures included the pituitary fossa, cavernous sinus, and cavernous internal carotid artery, but this exposure did not result in an increase in perioperative complications. Sclerotic thickening of the sinus walls persisted, probably representing a chronic osteitis in response to concurrent bacterial infection. This appeared to be protective against further sinus wall erosions. Wall erosions did not heal. One patient demonstrated what appeared to be invasive fungal disease from a fungal ball.
   Conclusions: Sphenoid sinus fungal balls can occur with minimal symptoms in a mainly elderly population and require surgical removal. Sphenoid sinus fungal balls have a low rate of operative morbidity and should be effectively managed by transnasal endoscopic sphenoidotomy alone.
C1 Greenslopes Private Hosp, Dept Otorhinolaryngol Head & Neck Surg, Greenslopes, Australia.
   Princess Alexandra Hosp, Dept Otorhinolaryngol, Buranda, Australia.
   Princess Alexandra Hosp, Dept Radiol, Buranda, Australia.
RP Bowman, J (reprint author), Toowoomva Hlth Serv, Surg Outpatients, PMB 2, Toowoomba, Qld 4350, Australia.
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   Nussenbaum B, 2001, OTOLARYNG HEAD NECK, V124, P150, DOI 10.1067/mhn.2001.112573
   Scharf JL, 2004, LARYNGOSCOPE, V114, P1533, DOI 10.1097/00005537-200409000-00005
   Schlosser RJ, 2002, AM J RHINOL, V16, P161
   Thiagalingam S, 2004, CLIN EXP OPHTHALMOL, V32, P545, DOI 10.1111/j.1442-9071.2004.00877.x
NR 11
TC 14
Z9 15
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD JUL
PY 2007
VL 116
IS 7
BP 514
EP 519
PG 6
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 192AZ
UT WOS:000248174400006
PM 17727082
ER

PT J
AU Ito, K
   Shimoto, SI
   Karino, S
AF Ito, Ken
   Shimoto, Shin-ich
   Karino, Shotaro
TI Isolated cochlear nerve hypoplasia with various internal auditory meatus
   deformities in children
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE auditory brain stem response; distortion product otoacoustic emission;
   isolated cochlear nerve hypoplasia; juvenile and adolescent unilateral
   deafness; narrow internal auditory meatus; vestibular evoked myogenic
   response
AB Objectives: We report neuro-otological findings in isolated congenital cochlear nerve hypoplasia with various bony deformities and evaluate relationships between functional impairment and the radiologic dimensions of the internal auditory meatus (IAM).
   Methods: We performed imaging and functional analyses on consecutive juvenile or adolescent patients between 2001 and 2005 with "isolated" unilateral hypoplasia of the cochlear nerve, without inner ear anomaly or other deformities.
   Results: Among 20 patients with unilateral profound deafness who underwent imaging studies, 10 (50%) passed the inclusion criteria. In all affected ears, auditory brain stem responses were absent and the speech discrimination score was very poor (0% to 5%). Distortion product otoacoustic emissions were good in 2 ears, fair in I ear, and poor in 7 ears. Caloric responses were absent in 2 ears, reduced in 3 ears, and normal in 5 ears. Inferior vestibular nerve function and facial nerve function were normal in all ears. Distortion product otoacoustic emissions and caloric responses tended to be better in ears with less severe narrowing of the IAM.
   Conclusions: The risk of co-involvement of the inner ear and superior vestibular nerve functions is higher in the presence of a narrower bony IAM. Cochlear nerve hypoplasia is proposed as one of the most important causes of juvenile unilateral deafness because of its unexpectedly high incidence.
C1 Univ Tokyo, Fac Med, Dept Otolaryngol, Tokyo 113, Japan.
RP Ito, K (reprint author), Univ Tokyo, Fac Med, Dept Otolaryngol, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1138655, Japan.
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   Ito K, 1998, ARCH OTOLARYNGOL, V124, P1389
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NR 8
TC 3
Z9 3
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD JUL
PY 2007
VL 116
IS 7
BP 520
EP 524
PG 5
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 192AZ
UT WOS:000248174400007
PM 17727083
ER

PT J
AU Powell, SA
   Nguyen, CT
   Gaziano, J
   Lewis, V
   Lockey, RF
   Padhya, TA
AF Powell, Scott A.
   Nguyen, Chau T.
   Gaziano, Joy
   Lewis, Vicki
   Lockey, Richard F.
   Padhya, Tapan A.
TI Mass psychogenic illness presenting as acute stridor in an adolescent
   female cohort
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE adolescent; airway obstruction; conversion disorder; paradoxical vocal
   cord dysfunction; speech therapy; stridor
ID VOCAL CORD MOTION; UPPER AIRWAY-OBSTRUCTION; DIAGNOSIS; MANAGEMENT;
   INFECTION; ASTHMA; ASSOCIATION; PNEUMONIAE; BRONCHITIS; CHILDHOOD
AB Objectives: We describe a cohort of patients with an unusual presentation of stridor, their evaluation and management, and their outcome. We review the pertinent English-language literature.
   Methods: We performed a retrospective review of the records of 12 adolescent patients treated for acute-onset inspiratory stridor at the Departments of Otolaryngology-Head and Neck Surgery and Allergy and Immunology at the University of South Florida and the Department of Speech Pathology at the H. Lee Moffitt Cancer Center and Research Institute. Two additional patients received treatment elsewhere. Demographic, historical, and laboratory data, physical examination findings, and follow-up information were extracted. A review of both the Hillsborough County Department of Health epidemiological report and the English-language literature was performed.
   Results: Fourteen female patients who attended a local high school developed audible inspiratory noise. Twelve of the 14 were seen at the University of South Florida Ear, Nose and Throat Center. The remaining 2 patients were evaluated by outside otolaryngologists but were included in all reports from the Department of Health. Environmental studies did not find noxious chemical or biological agents in the students' environments to explain the development of the symptoms. Physical and videostroboscopic examination identified two distinct laryngeal findings causing the audible stridor. One involved paradoxical vocal fold movement, and the other, supraglottic mucosal collapse into the airway. All patients underwent rigorous speech pathology intervention and structured treatment with either complete resolution or significant improvement, seen both clinically and on videostroboscopic evaluation.
   Conclusions: Audible stridor can arise from numerous disease processes. In the vast majority of presentations it occurs sporadically and on an individual basis. Our cohort is especially unusual because of the sheer number of patients. Our presentation of a case of mass psychogenic illness as the cause of vocal cord dysfunction with additional findings of laryngomalacia within a group of adolescent girls is the first in the English-language literature. The key to the diagnosis is recognition of the disorder and susceptible individuals by using a thorough physical examination with emphasis on the laryngoscopic and videostroboscopic findings. The systematic approach, undertaken by a team including an otolaryngologist, an allergist, a speech pathologist, and an epidemiologist, proved to be effective in the management of this complex disorder and highly unusual situation.
C1 Univ S Florida, Coll Med, Dept Otolaryngol Head & Neck Surg, Tampa, FL 33612 USA.
   Univ S Florida, Coll Med, Dept Allergy & Immunol, Tampa, FL 33612 USA.
   H Lee Moffitt Canc Ctr & Res Inst, Dept Speech Pathol, Tampa, FL USA.
RP Padhya, TA (reprint author), Univ S Florida, Coll Med, Dept Otolaryngol Head & Neck Surg, 12901 Bruce B Downs Blvd,MDC 73, Tampa, FL 33612 USA.
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NR 33
TC 3
Z9 3
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD JUL
PY 2007
VL 116
IS 7
BP 525
EP 531
PG 7
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 192AZ
UT WOS:000248174400008
PM 17727084
ER

PT J
AU Merchant, SN
   Nakajima, HH
   Halpin, C
   Nadol, JB
   Lee, DJ
   Innis, WP
   Curtin, H
   Rosowski, JJ
AF Merchant, Saumil N.
   Nakajima, Hideko H.
   Halpin, Christopher
   Nadol, Joseph B., Jr.
   Lee, Daniel J.
   Innis, William P.
   Curtin, Hugh
   Rosowski, John J.
TI Clinical investigation and mechanism of air-bone gaps in large
   vestibular aqueduct syndrome
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE air-bone gap; audiometry; conductive hearing loss; large vestibular
   aqueduct syndrome
ID CONDUCTIVE HEARING-LOSS; SEMICIRCULAR CANAL DEHISCENCE; EVOKED MYOGENIC
   POTENTIALS; TYMPANIC MEMBRANE; MIDDLE-EAR; INNER-EAR; CHINCHILLA;
   FIXATION
AB Objectives: Patients with large vestibular aqueduct syndrome (LVAS) often demonstrate an air-bone gap at the low frequencies on audiometric testing. The mechanism causing such a gap has not been well elucidated. We investigated middle ear sound transmission in patients with LVAS, and present a hypothesis to explain the air-bone gap.
   Methods: Observations were made on 8 ears from 5 individuals with LVAS. The diagnosis of LVAS was made by computed tomography in all cases. Investigations included standard audiometry and measurements of umbo velocity by laser Doppler vibrometry (LDV) in all cases, as well as tympanometry, acoustic reflex testing, vestibular evoked myogenic potential (VEMP) testing, distortion product otoacoustic emission (DPOAE) testing, and middle ear exploration in some ears.
   Results: One ear with LVAS had anacusis. The other 7 ears demonstrated air-bone gaps at the low frequencies, with mean gaps of 51 dB at 250 Hz, 31 dB at 500 Hz, and 12 dB at 1,000 Hz. In these 7 ears with air-bone gaps, LDV showed the umbo velocity to be normal or high normal in all 7; tympanometry was normal in all 6 ears tested; acoustic reflexes were present in 3 of the 4 ears tested; VEMP responses were present in all 3 ears tested; DPOAEs were present in I of the 2 ears tested, and exploratory tympanotomy in I case showed a normal middle ear. The above data suggest that an air-bone gap in LVAS is not due to disease in the middle ear. The data are consistent with the hypothesis that a large vestibular aqueduct introduces a third mobile window into the inner ear, which can produce an air-bone gap by 1) shunting air-conducted sound away from the cochlea, thus elevating air conduction thresholds, and 2) increasing the difference in impedance between the scala vestibuli side and the scala tympani side of the cochlear partition during bone conduction testing, thus improving thresholds for bone-conducted sound.
   Conclusions: We conclude that LVAS can present with an air-bone gap that can mimic middle ear disease. Diagnostic testing using acoustic reflexes, VEMPs, DPOAEs, and LDV can help to identify a non-middle ear source for such a gap, thereby avoiding negative middle ear exploration. A large vestibular aqueduct may act as a third mobile window in the inner ear, resulting in an air-bone gap at low frequencies.
C1 Massachusetts Eye & Ear Infirm, Dept Otolaryngol, Boston, MA 02114 USA.
   Harvard Univ, Sch Med, Dept Otol & Laryngol, Cambridge, MA 02138 USA.
   Boston Med Ctr, Dept Otolaryngol, Boston, MA USA.
   Boston Univ, Sch Med, Boston, MA 02118 USA.
   MIT, Div Hlth Sci & Technol, Cambridge, MA 02139 USA.
   Univ Massachusetts, Mem Med Ctr, Dept Surg, Div Otolaryngol, Worcester, MA 01605 USA.
   Univ Massachusetts, Sch Med, Worcester, MA USA.
RP Merchant, SN (reprint author), Massachusetts Eye & Ear Infirm, Dept Otolaryngol, 243 Charles St, Boston, MA 02114 USA.
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NR 28
TC 36
Z9 42
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD JUL
PY 2007
VL 116
IS 7
BP 532
EP 541
PG 10
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 192AZ
UT WOS:000248174400009
PM 17727085
ER

PT J
AU Yetiser, S
   Karapinar, U
AF Yetiser, Sertac
   Karapinar, Ugur
TI Hypoglossal-facial nerve anastomosis: A meta-analytic study
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE etiology; hypoglossal-facial nerve anastomosis; meta-analysis; timing of
   repair
ID CEREBELLOPONTINE ANGLE TUMORS; ACOUSTIC NEUROMA; PARALYZED FACE; SURGERY
   OUTCOMES; TECHNICAL NOTE; PALSY; REHABILITATION; REANIMATION; REMOVAL;
   EXPERIENCE
AB Objectives: A meta-analysis was conducted on the outcome of facial nerve function after hypoglossal-facial nerve anastomosis in humans. The roles of the timing of and the underlying cause for surgery, the type of the repair, and previous facial nerve function in the final result were analyzed.
   Methods: Articles were identified by means of a PubMed search using the key words "facial-hypoglossal anastomosis," which yielded 109 articles. The data were pooled from existing literature written in English or French. Twenty-three articles were included in the study after we excluded those that were technical reports, those describing anastomosis to cranial nerves other than the hypoglossal, and those that were experimental animal studies. Articles that reported facial nerve function after surgery and timing of repair were included. Facial nerve function had to be reported according to the House-Brackmann scale. If there was more than I article by the same author(s), only the most recent article and those that did not overlap and that matched the above criteria were accepted. The main parameter of interest was the rate of functional recovery of the facial nerve after anastomosis. This parameter was compared among all groups with Pearson's chi(2) test in the SPSS program for Windows. Statistical significance was set at a p level of less than .05.
   Results: Analysis of the reports indicates that early repair, before 12 months, provides a better outcome. The severity of facial nerve paralysis does not have a negative effect on prognosis. Gunshot wounds and facial neuroma are the worst conditions for favorable facial nerve recovery after anastomosis. Transection of the hypoglossal nerve inevitably results in ipsilateral tongue paralysis and atrophy. Modification of the anastomosis technique seems to resolve this problem. Nevertheless, the effect of modified techniques on facial reanimation is still unclear, because the facial nerve function results were lacking in these reports.
   Conclusions: Hypoglossal-facial nerve anastomosis is an effective and reliable technique that gives consistent and satisfying results.
C1 Gulhane Mil Med Acad, Dept Otorhinolaryngol Head & Neck Surg, TR-06018 Ankara, Turkey.
RP Yetiser, S (reprint author), Gulhane Mil Med Acad, Dept Otorhinolaryngol Head & Neck Surg, TR-06018 Ankara, Turkey.
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NR 32
TC 19
Z9 22
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD JUL
PY 2007
VL 116
IS 7
BP 542
EP 549
PG 8
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 192AZ
UT WOS:000248174400010
PM 17727086
ER

PT J
AU Bercin, AS
   Ural, A
   Kutluhan, A
   Yurttas, V
AF Bercin, A. Sami
   Ural, Ahmet
   Kutluhan, Ahmet
   Yurttas, Veysel
TI Relationship between sinusitis and adenoid size in pediatric age group
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE adenoid vegetation; pediatric population; sinusitis
ID CHILDREN; SINUSES; RHINOSINUSITIS; SYMPTOMS; SURGERY; INFANTS
AB Objectives: We sought to examine the relationship between adenoid volume and the stage of rhinosinusitis, as well as the relationship between age and adenoid size.
   Methods: Forty-two children complaining of nasal discharge, whose paranasal sinus computed tornographic scans had been obtained, were involved in the study. The patients with adenoid enlargement underwent adenoidectomy. The volumes of adenoid vegetation were measured in square centimeters, and paranasal sinus computed tomographic scans were classified according to the Lund-Mackay staging system.
   Results: No statistically significant difference existed between patients whose Lund-Mackay scores were 0 and those with scores greater than 0. There seems to be no correlation between the Lund-Mackay score and the degree of adenoid vegetation.
   Conclusions: Adenoid vegetation may cause nasal discharge that is not necessarily due to sinusitis. We could not find any supportive data for the statement "The greater the adenoid tissue, the more extensive the sinusitis."
C1 Ankara Ataturk Teaching & Res Hosp, Otorhinolaryngol Clin, Ankara, Turkey.
RP Ural, A (reprint author), Mamak Cad 43-1, TR-06340 Ankara, Turkey.
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NR 23
TC 9
Z9 9
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD JUL
PY 2007
VL 116
IS 7
BP 550
EP 553
PG 4
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 192AZ
UT WOS:000248174400011
PM 17727087
ER

PT J
AU Lee, HM
   Kim, HY
   Kang, HJ
   Woo, JS
   Chae, SW
   Lee, SH
   Hwang, SJ
AF Lee, Heung-Man
   Kim, Hyo Yeol
   Kang, Hee Joon
   Woo, Jeong Soo
   Chae, Sung Won
   Lee, Sang Hag
   Hwang, Soon Jae
TI Up-regulation of protease-activated receptor 2 in allergic rhinitis
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE allergic rhinitis; protease-activated receptor
ID EPITHELIAL-CELLS; INFLAMMATION; RELEASE; AIRWAY; ADHESION; PAR-2; MICE
AB Objectives: We compared the patterns of PAR-2 messenger RNA (mRNA) and protein expression in the nasal mucosa of subjects with and without allergic rhinitis.
   Methods: Biopsy specimens were obtained from 10 patients with allergic rhinitis and 10 normal controls. RNA was extracted from the nasal mucosa, and semiquantitative reverse transcription-polymerase chain reaction was performed for PAR-2. Tissue sections were immunostained for PAR-2 by use of specific antibody.
   Results: The expression levels of PAR-2 mRNA in allergic rhinitis nasal mucosa were significantly up-regulated as compared with those in normal nasal mucosa. PAR-2 immunoreactivity was observed in the epithelium and submucosal glands in both normal controls and subjects with allergic rhinitis. Stronger immunoreactivity for PAR-2 was observed in allergic rhinitis nasal mucosa as compared with normal nasal mucosa.
   Conclusions: These results suggest that PAR-2 may be involved in allergic nasal inflammation.
C1 Korea Univ, Coll Med, Dept Otolaryngol Head & Neck Surg, Seoul, South Korea.
   Korea Univ, Coll Med, Div Brain Korea 21 Program Biomed Sci, Seoul, South Korea.
RP Lee, HM (reprint author), Korea Univ, Coll Med, Dept Otolaryngol Head & Neck Surg, Guro Hosp, 80 Guro Dong,Guro Gu, Seoul 152703, South Korea.
CR Asokananthan N, 2002, J IMMUNOL, V168, P3577
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   Takizawa T, 2005, J PHARMACOL SCI, V98, P99, DOI 10.1254/jphs.SCZ050138
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NR 17
TC 10
Z9 12
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD JUL
PY 2007
VL 116
IS 7
BP 554
EP 558
PG 5
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 192AZ
UT WOS:000248174400012
PM 17727088
ER

PT J
AU Rodriguez, KH
   Roth, CR
   Rees, CJ
   Belafsky, PC
AF Rodriguez, Kimsey H.
   Roth, Carole R.
   Rees, Catherine J.
   Belafsky, Peter C.
TI Reliability of the pharyngeal squeeze maneuver
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE fiberoptic endoscopic evaluation of swallowing with sensory testing;
   pharyngeal motor function; pharyngeal squeeze maneuver
ID ASPIRATION
AB Objectives: Fiberoptic endoscopic evaluation of swallowing with sensory testing has been used to assess the integrity of laryngopharyngeal sensory and motor components. The pharyngeal squeeze is a maneuver used during fiberoptic endoscopic evaluation of swallowing with sensory testing to assess pharyngeal motor function. Although the pharyngeal squeeze manuever has been used in numerous scientific publications, its reliability has not been critically evaluated. Therefore, we sought to evaluate the reliability of the pharyngeal squeeze maneuver.
   Methods: Forty individuals who were undergoing fiberoptic laryngoscopy for various reasons were instructed to perform the pharyngeal squeeze maneuver. Three different clinicians reviewed the videotape on 4 separate occasions. The clinicians were first asked to rate each side of the pharynx as normal, diminished, or absent. They were then instructed to simply rate the maneuver as normal or abnormal. The interobserver and intraobserver reliability of the pharyngeal squeeze maneuver were assessed with the kappa coefficient.
   Results: The mean age of the cohort was 58 years. Fifty-eight percent (23 of 40) were male. When the clinicians were instructed to rate each side of the pharynx as normal, diminished, or absent, the interobserver and intraobserver reliabilities were poor (63% to 68% agreement; kappa = 0.18 to 0.67). When the clinicians were asked to rate the pharyngeal squeeze maneuver as normal or abnormal, both interobserver and intraobserver reliabilities were excellent (85% to 98% agreement; kappa = 0.75 to 0.95).
   Conclusions: The pharyngeal squeeze maneuver displayed poor reliability when motor function was classified into unilateral or bilateral normal, diminished, and absent categories. The pharyngeal squeeze maneuver was very reliable when simply graded as normal or abnormal. Clinicians could not reliably distinguish between diminished and absent pharyngeal motor functions.
C1 Scripps Ctr Voice & Swallowing, La Jolla, CA USA.
   Tulane Univ, Dept Otolaryngol, New Orleans, LA 70118 USA.
   Univ Calif Davis, Med Ctr, Dept Otolaryngol, Ctr Voice & Swallowing, Sacramento, CA 95817 USA.
RP Belafsky, PC (reprint author), Univ Calif Davis, Med Ctr, Dept Otolaryngol, Ctr Voice & Swallowing, Sacramento, CA 95817 USA.
RI Rodriguez, Kimsey/A-6067-2011
CR Aviv J E, 1998, Ann Otol Rhinol Laryngol, V107, P378
   Aviv JE, 2000, LARYNGOSCOPE, V110, P563, DOI 10.1097/00005537-200004000-00008
   Aviv JE, 2002, LARYNGOSCOPE, V112, P338, DOI 10.1097/00005537-200202000-00025
   Bastian Robert W., 1993, Dysphagia, V8, P359, DOI 10.1007/BF01321780
   Kidder Thomas M., 1994, Dysphagia, V9, P256, DOI 10.1007/BF00301919
   LANGMORE SE, 1991, ANN OTO RHINOL LARYN, V100, P678
   Setzen M, 2003, OTOLARYNG HEAD NECK, V128, P99, DOI 10.1067/mhn.2003.52
NR 7
TC 4
Z9 4
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD JUN
PY 2007
VL 116
IS 6
BP 399
EP 401
PG 3
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 181NW
UT WOS:000247444400001
PM 17672239
ER

PT J
AU Cohen, SM
   Jacobson, BH
   Garrett, CG
   Noordzij, JP
   Stewart, MG
   Attia, A
   Ossoff, RH
   Cleveland, TF
AF Cohen, Seth M.
   Jacobson, Barbara H.
   Garrett, C. Gaelyn
   Noordzij, J. Pieter
   Stewart, Michael G.
   Attia, Albert
   Ossoff, Robert H.
   Cleveland, Thomas F.
TI Creation and validation of the singing voice handicap index
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT Annual Meeting of the American-Laryngological-Association
CY APR 26-27, 2007
CL San Diego, CA
SP Amer Laryngol Assoc
DE larynx; quality of life; singing; voice
ID DISORDERS; SINGERS; IMPACT
AB Objectives: We developed and validated a disorder-specific health status instrument (Singing Voice Handicap Index; SVHI) for use in patients with singing problems.
   Methods: Prospective instrument validation was performed. of 81 original items, those with poor statistical validity were eliminated, resulting in 36 items. The ability to discriminate dysphonic from normal singers, test-retest reliability, internal consistency, and construct validity were assessed.
   Results: We included 112 dysphonic and 129 normal singers, professional and nonprofessional, of classical, country, rock, choral, and gospel repertoire. Dysphonic singers had worse SVHI scores than normal singers (p <= .001, rank sum test). Test-retest reliability was high (Spearman correlation, 0.92; p <= .001). Internal consistency demonstrated a Cronbach's alpha of .97, and the correlation between the SVHI and self-rated singing voice impairment was .63 (p <= .001, Spearman correlation).
   Conclusions: The SVHI is a reliable and valid tool for assessing self-perceived handicap associated with singing problems.
C1 Duke Univ, Med Ctr, Div Otolaryngol Head & Neck Surg, Duke Voice Care Ctr, Durham, NC 27710 USA.
   Vanderbilt Univ, Ctr Med, Vanderbilt Voice Ctr, Nashville, TN 37232 USA.
   Vanderbilt Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, Nashville, TN 37232 USA.
   Boston Univ, Dept Otolaryngol Head & Neck Surg, Boston, MA 02215 USA.
   Cornell Univ, Weill Med Coll, Dept Otorhinolaryngol, Ithaca, NY 14853 USA.
RP Cohen, SM (reprint author), Duke Univ, Med Ctr, Div Otolaryngol Head & Neck Surg, Duke Voice Care Ctr, Box 3805, Durham, NC 27710 USA.
CR Behrman A, 2004, LARYNGOSCOPE, V114, P1693, DOI 10.1097/00005537-200410000-00004
   Benninger MS, 1998, J VOICE, V12, P540, DOI 10.1016/S0892-1997(98)80063-5
   Cohen SM, 2006, ANN OTO RHINOL LARYN, V115, P128
   Deary IJ, 2003, J PSYCHOSOM RES, V54, P483, DOI 10.1016/S0022-3999(02)00469-5
   Gliklich RE, 1999, OTOLARYNG HEAD NECK, V120, P153, DOI 10.1016/S0194-5998(99)70399-2
   Hogikyan ND, 1999, J VOICE, V13, P557, DOI 10.1016/S0892-1997(99)80010-1
   Jacobson BH, 1997, AM J SPEECH-LANG PAT, V6, P66
   Morsomme D, 2005, Rev Laryngol Otol Rhinol (Bord), V126, P305
   Phyland DJ, 1999, J VOICE, V13, P602, DOI 10.1016/S0892-1997(99)80014-9
   Rosen CA, 2000, J VOICE, V14, P370, DOI 10.1016/S0892-1997(00)80082-X
   Rosen CA, 2004, LARYNGOSCOPE, V114, P1549, DOI 10.1097/00005537-200409000-00009
   Roy N, 2005, LARYNGOSCOPE, V115, P1988, DOI 10.1097/01.mlg.0000179174.32345.41
   World Health Organization, 1980, INT CLASS IMP DIS HA, P25
NR 13
TC 22
Z9 25
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD JUN
PY 2007
VL 116
IS 6
BP 402
EP 406
PG 5
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 181NW
UT WOS:000247444400002
PM 17672240
ER

PT J
AU Bovo, R
   Ortore, R
   Ciorba, A
   Berto, A
   Martini, A
AF Bovo, Roberto
   Ortore, Rocco
   Ciorba, Andrea
   Berto, Anna
   Martini, Alessandro
TI Bilateral sudden profound hearing loss and vertigo as a unique
   manifestation of bilateral symmetric inferior pontine infarctions
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE bilateral sudden hearing loss; cochlear nucleus infarction; pontine
   infarction; sudden hearing loss; vertigo; vestibular nucleus infarction
ID BASILAR ARTERY-OCCLUSION; VERTEBROBASILAR INSUFFICIENCY; DEAFNESS
AB Objectives: We present a case of sudden bilateral profound deafness and vertigo, without any accompanying neurologic signs, secondary to bilateral infarctions of the cochlear and vestibular nuclei.
   Methods: Vertigo, vomiting, tinnitus, and bilateral profound deafness suddenly developed in a 65-year-old woman without any accompanying neurologic signs. In particular, she did not present dysarthria, numbness, cranial nerve palsies, or visual or cerebellar signs.
   Results: Magnetic resonance imaging of the brain revealed 2 fresh infarctions of 8 to 10 rum symmetrically localized in the posterolateral bulbopontine junction. Angiography revealed a complete occlusion of the basilar artery, with a well-represented backward flow of its distal portion from the carotid artery via posterior communicating arteries. Excluding a transient ischemic attack that occurred 16 days after the acute episode, the patient had had no other neurologic events at 8 months of follow-up.
   Conclusions: Acute vertigo and sudden deafness in a patient with known cerebrovascular occlusive disease may represent the warning signs of an impending brain stem or cerebellar infarction, even when other neurologic signs are absent. These events are fortunately very rare, but should be considered by clinicians who see patients with vertigo.
C1 Univ Ferrara, Dept Audiol, I-44100 Ferrara, Italy.
RP Bovo, R (reprint author), Arcispedle S Anna, Dept Audiol, Corso Giovecca 203, I-44100 Ferrara, Italy.
CR BOGOUSSLAVSKY J, 1991, NEUROLOGY, V41, P855
   Deplanque D, 1998, J NEUROL NEUROSUR PS, V64, P817
   Fetterman BL, 1996, LARYNGOSCOPE, V106, P1347, DOI 10.1097/00005537-199611000-00008
   Huang CC, 2005, EUR ARCH OTO-RHINO-L, V262, P576, DOI 10.1007/s00405-004-0874-1
   HUANG MH, 1993, STROKE, V24, P132
   Ichikawa H, 1994, Rinsho Shinkeigaku, V34, P569
   Lee H, 2005, J NEUROL SCI, V228, P99, DOI 10.1016/j.jns.2004.10.016
   Lee H, 2003, J NEUROL NEUROSUR PS, V74, P539, DOI 10.1136/jnnp.74.4.539
   LEHNHARDT E, 1991, HNO, V39, P378
   Schmiz A, 2000, LARYNGO RHINO OTOL, V79, P253
   Sunose H, 2000, OTOLARYNG HEAD NECK, V122, P146, DOI 10.1016/S0194-5998(00)70165-3
   Toyoda K, 2002, J NEUROL SCI, V193, P147, DOI 10.1016/S0022-510X(01)00663-3
   Welsh LW, 2003, ANN OTO RHINOL LARYN, V112, P657
NR 13
TC 5
Z9 5
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD JUN
PY 2007
VL 116
IS 6
BP 407
EP 410
PG 4
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 181NW
UT WOS:000247444400003
PM 17672241
ER

PT J
AU Welham, NV
   Dailey, SH
   Ford, CN
   Bless, DM
AF Welham, Nathan V.
   Dailey, Seth H.
   Ford, Charles N.
   Bless, Diane M.
TI Voice handicap evaluation of patients with pathologic sulcus vocalis
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT Annual Meeting of the American-Laryngological-Association
CY APR 26-27, 2007
CL San Diego, CA
SP Amer Laryngol Assoc
DE dysphonia; sulcus vocalis; voice disorder; Voice Handicap Index
AB Objectives: The purpose of this study was to characterize the psychosocial impact of dysphonia on patients with pathologic sulcus vocalis by use of the Voice Handicap Index (VHI).
   Methods: The VHI was administered to 15 patients (11 women and 4 men) with pathologic sulcus vocalis. The VHI subscale and total scores were compared with previously published data from individuals with no history of dysphonia and from patients with vocal fold scar. Additional comparisons were performed for patients with unilateral sulcus versus bilateral sulci, type 11 sulcus versus type III sulcus, and sulcus with concomitant vocal fold scar versus sulcus without concomitant scar.
   Results: The VHI scores for patients with pathologic sulcus vocalis were significantly greater than those for individuals with no history of dysphonia and for patients with vocal fold scar. In addition, significantly greater VHI scores were observed for patients with sulcus vocalis with concomitant scar versus those with sulcus alone.
   Conclusions: These data suggest that pathologic sulcus vocalis can be a severely handicapping condition, particularly in the presence of concomitant scar.
C1 Univ Wisconsin, Sch Med & Publ Hlth, Div Otolaryngol, Dept Surg, Madison, WI 53706 USA.
RP Welham, NV (reprint author), Clin Sci Ctr K4 719, 600 Highland Ave, Madison, WI 53702 USA.
CR BOGAARDT HC, IN PRESS J VOICE
   BOUCHAYER M, 1985, LARYNGOSCOPE, V95, P1087
   Dailey SH, 2007, J VOICE, V21, P112, DOI 10.1016/j.jvoice.2005.09.006
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   Hirano M, 1981, CLIN EXAMINATION VOI
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NR 19
TC 7
Z9 7
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD JUN
PY 2007
VL 116
IS 6
BP 411
EP 417
PG 7
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 181NW
UT WOS:000247444400004
PM 17672242
ER

PT J
AU Powitzky, R
   Powitzky, ES
   Garcia, R
AF Powitzky, Rosser
   Powitzky, Eric S.
   Garcia, Rafael
TI Liposarcoma of the larynx
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT 110th Annual Meeting of the
   American-Academy-of-Otolaryngology-Head-and-Neck-Surgery
CY SEP 17-20, 2006
CL Toronto, CANADA
SP Amer Acad Otolaryngol Head & Neck Surg
DE cancer; laryngeal neoplasm; larynx; liposarcoma
ID SOFT-TISSUE; DEDIFFERENTIATED LIPOSARCOMA; PROGNOSTIC-FACTORS;
   SARCOMA-GROUP; CHEMOTHERAPY; CARCINOMA; SUBTYPES; GRADE
AB Objectives: The objective was to review the presentation, diagnosis, treatment, and prognosis of patients with laryngeal liposarcoma (LLS). A case is reported, and a retrospective review of the English-language literature is presented.
   Methods: All published cases of LLS with adequate histopathologic documentation and clinical information were included for review.
   Results: Thirty cases of LLS have been reported. A majority of these patients are men between 40 and 70 years of age. The most common location of the tumor is the supraglottis, and the presenting complaints are similar to those of other laryngeal neoplasms. Although these neoplasms recur often and can cause significant morbidity, they are typically of low grade and rarely metastasize. The outcomes of this disease are generally good when it is treated with wide surgical excision.
   Conclusions: Cases of LLS are extremely rare. Because the histologic changes are frequently subtle, LLS can be easily mistaken for a benign tumor. As a result, the diagnosis requires a high index of suspicion and diligence in examining biopsy specimens. Computed tomography and magnetic resonance imaging can assist in the diagnosis and surgical approach. Genetic and immunostaining analysis techniques may also prove to have valuable prognostic, diagnostic, and therapeutic implications for this disease. Wide surgical excision is the mainstay of treatment. The use of radiotherapy and chemotherapy in treating this cancer remains experimental, but might be considered on a case-to-case basis for palliation or to treat aggressive variants of the disease.
C1 Ctr ENT, Houston, TX 77030 USA.
   Texas Tech Hlth Sci Ctr, Sch Med, El Paso, TX USA.
   El Paso Ear Nose & Throat Associates, Div Head & Neck Oncol, El Paso, TX USA.
RP Powitzky, ES (reprint author), Ctr ENT, 6624 Fannin St, Houston, TX 77030 USA.
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NR 37
TC 6
Z9 6
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD JUN
PY 2007
VL 116
IS 6
BP 418
EP 424
PG 7
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 181NW
UT WOS:000247444400005
PM 17672243
ER

PT J
AU Tosun, F
   Hidir, Y
   Saracli, MA
   Caliskaner, Z
   Sengul, A
AF Tosun, Fuat
   Hidir, Yusuf
   Saracli, Mehmet A.
   Caliskaner, Zafer
   Sengul, Ali
TI Intranasal fungi and chronic rhinosinusitis: What is the relationship?
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE chronic rhinosinusitis; fungus; polymerase chain reaction
ID POLYMERASE-CHAIN-REACTION; IMMUNOGLOBULIN-E; NASAL POLYPS; SINUSITIS;
   PATHOPHYSIOLOGY; DIAGNOSIS
AB Objectives: The aim of this study was to investigate the effects of intranasal fungi on chronic rhinosinusitis (CRS)
   Methods: Forty-one patients with CRS were included in the study. The patients were put into 2 groups, with and without intranasal fungi as detected by polymerase chain reaction, and were compared in terms of different laboratory and clinical parameters of CRS. A chi(2) test was used to analyze statistical differences between the 2 groups.
   Results: Serum eosinophilia, eosinophilia in the nasal mucus, prick and intradermal test positivity for fungi, elevated total IgE, fungal-specific IgE, prevalence of symptoms, frequency of bronchial asthma, aspirin sensitivity, and nasal polyposis did not differ significantly between the 2 groups of patients (p > .05).
   Conclusions: The findings of this study failed to reveal a clear correlation between the presence of fungi in the nasal passage and various factors that are assumed to be involved in the pathogenesis or clinical course of CRS. If fungi have a role in the pathogenesis of CRS, it may be via other mediators and reactions rather than IgE and type I hypersensitivity. However, the sample size was relatively small, and further studies with more cases are needed on the same topic.
C1 Gulhane Mil Med Acad, Dept Otolaryngol Head & Neck Surg, TR-06018 Ankara, Turkey.
   Gulhane Mil Med Acad, Dept Clin Microbiol, TR-06018 Ankara, Turkey.
   Gulhane Mil Med Acad, Dept Allerg Dis, TR-06018 Ankara, Turkey.
   Gulhane Mil Med Acad, Dept Immunol, TR-06018 Ankara, Turkey.
RP Tosun, F (reprint author), Gulhane Mil Med Acad, Dept Otolaryngol Head & Neck Surg, TR-06018 Ankara, Turkey.
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NR 19
TC 6
Z9 7
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD JUN
PY 2007
VL 116
IS 6
BP 425
EP 429
PG 5
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 181NW
UT WOS:000247444400006
PM 17672244
ER

PT J
AU Rahbar, R
   Brown, LF
   Folkman, J
   McGill, TJ
   Healy, GB
   Liu, GM
   Vargas, SO
AF Rahbar, Reza
   Brown, Lawrence F.
   Folkman, Judah
   McGill, Trevor J.
   Healy, Gerald B.
   Liu, Guanmei
   Vargas, Sara O.
TI Role of vascular endothelial growth factor A in children with acquired
   airway stenosis
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT 86th Annual Meeting of the American-Broncho-Esophagological-Association
CY MAY 19-20, 2006
CL Chicago, IL
SP Amer Broncho Esophagol Assoc
DE airway stenosis; angiogenesis; vascular endothelial growth factor A
ID PERMEABILITY FACTOR; SUBGLOTTIC STENOSIS; GRANULATION-TISSUE; VEGF
   EXPRESSION; FACTOR RECEPTOR; MESSENGER-RNA; ACCUMULATION; LARYNGEAL;
   CELLS; MODEL
AB Objectives: Vascular endothelial growth factor A (VEGF-A) is important in the angiogenic response for wound healing. This study investigated whether VEGF-A may play a role in the pathogenesis of acquired airway stenosis.
   Methods: Eight lesions from 5 pediatric patients with subglottic stenosis after airway reconstruction (N = 4) or prolonged intubation (N = 1) and normal laryngeal tissue from 5 autopsy patients were included. Formalin-fixed sections of subglottic tissue from each patient were examined by in situ hybridization for the presence of messenger RNA (mRNA) for VEGF-A, vascular endothelial growth factor receptor 1 (VEGFR-1), and vascular endothelial growth factor receptor 2 (VEGFR-2).
   Results: Strong expression of VEGF-A mRNA was noted in hyperplastic squamous epithelium overlying granulation C, tissue. Strong expression of VEGFR-1 and VEGFR-2 was noted in the endothelial cells within granulation tissue. No strong labeling of VEGF-A mRNA or its receptors was noted in 2 specimens with mature scar tissue or in the control specimens.
   Conclusions: The angiogenic growth factor VEGF-A is strongly expressed in hyperplastic epithelium overlying granulation tissue in airway stenosis. Also, VEGFR-1 and VEGFR-2 mRNAs are strongly expressed in the endothelial cells of granulation tissue. This finding suggests an important role of VEGF-A in the pathogenesis of airway scar formation and stenosis.
C1 Childrens Hosp, Dept Otolaryngol, Boston, MA 02115 USA.
   Childrens Hosp, Dept Commun Disorders, Boston, MA 02115 USA.
   Childrens Hosp, Dept Surg, Boston, MA 02115 USA.
   Childrens Hosp, Dept Pathol, Boston, MA 02115 USA.
   Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Boston, MA 02114 USA.
RP Rahbar, R (reprint author), Childrens Hosp, Dept Otolaryngol, 300 Longwood Ave, Boston, MA 02115 USA.
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NR 38
TC 5
Z9 5
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD JUN
PY 2007
VL 116
IS 6
BP 430
EP 435
PG 6
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 181NW
UT WOS:000247444400007
PM 17672245
ER

PT J
AU Mesallam, TA
   Stemple, JC
   Sobeih, TM
   Elluru, RG
AF Mesallam, Tamer A.
   Stemple, Joseph C.
   Sobeih, Tarek M.
   Elluru, Ravindhra G.
TI Reflux symptom index versus Reflux Finding Score
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT 86th Annual Meeting of the American-Broncho-Esophagological-Association
CY MAY 19-20, 2006
CL Chicago, IL
SP Amer Broncho Esophagol Assoc
DE laryngopharyngeal reflux; Reflux Finding Score; Reflux Symptom Index;
   symptom-to-sign correlation
ID LARYNGOPHARYNGEAL REFLUX; PH; AGREEMENT; LARYNGOSCOPY; RELIABILITY;
   ASSOCIATION; DIAGNOSIS; VALIDITY; PROBE
AB Objectives: We examined the correlation between the Reflux Symptom Index (RSI) and the Reflux Finding Score (RFS) to determine the laryngeal signs and symptoms that were most significantly correlated.
   Methods: Forty randomly selected patients were included in the study. A retrospective chart review was performed for patients who fit the inclusion criteria. Videostroboscopic samples for the study group were reviewed and RFS-rated by 6 experienced raters on 2 different occasions to evaluate the interrater and intrarater reliability. The RSI and the RFS were statistically compared regarding both the total scores and the individual parameters.
   Results: The RFS ranged from 0 to 20, and the RSI varied from 14 to 38. There was a high agreement between the raters' scores, demonstrating high interrater and intrarater reliability for RFS. Additionally, the RSI and RFS were highly correlated (p < .0001). Hoarseness was highly correlated with vocal fold edema and thick laryngeal mucus (p < .01), and excessive throat clearing correlated significantly with thick endolaryngeal mucus (p < .01).
   Conclusions: The study demonstrates a highly significant correlation between the RFS and the RSI.
C1 Blaine Block Voice Anal & Rehabil, Dayton, OH USA.
RP Elluru, RG (reprint author), Childrens Hosp, Ctr Med, Div Pediat Otolaryngol, MLC 2018,3333 Burnet Ave, Cincinnati, OH 45229 USA.
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NR 19
TC 19
Z9 20
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD JUN
PY 2007
VL 116
IS 6
BP 436
EP 440
PG 5
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 181NW
UT WOS:000247444400008
PM 17672246
ER

PT J
AU Heavner, SB
   Rubin, AD
   Fung, K
   Old, M
   Hogikyan, ND
   Feldman, EL
AF Heavner, S. Brett
   Rubin, Adam D.
   Fung, Kevin
   Old, Matthew
   Hogikyan, Norman D.
   Feldman, Eva L.
TI Dysfunction of the recurrent laryngeal nerve and the potential of gene
   therapy
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE crush injury; gene therapy; laryngeal paralysis; nerve injury; nerve
   regeneration; neurotrophic factor; recurrent laryngeal nerve; vocal fold
   paralysis
ID ADENOASSOCIATED VIRUS VECTORS; INJURED SPINAL-CORD; POSTERIOR
   CRICOARYTENOID MUSCLE; FOCAL CEREBRAL-ISCHEMIA; VOCAL FOLD PARALYSIS;
   GROWTH-FACTOR; NEUROTROPHIC FACTOR; CRICOTHYROID SUBLUXATION;
   BETA-GALACTOSIDASE; ADENOVIRUS VECTORS
AB Injury to the recurrent laryngeal nerve causes vocal fold paresis or paralysis resulting in poor voice quality, and possibly swallowing dysfunction and/or airway compromise. Injury can occur as part of a neurodegenerative disease process or can be due to direct nerve trauma or tumor invasion. Management depends upon symptoms, the cause and severity of injury, and the prognosis for recovery of nerve function. Surgical treatment techniques can improve symptoms, but do not restore physiologic motion. Gene therapy may be a useful adjunct to enhance nerve regeneration in the setting of neurodegenerative disease or trauma. Remote injection of viral vectors into the recurrent laryngeal nerve is the least invasive way to deliver neurotrophic factors to the nerve's cell bodies within the nucleus ambiguus, and in turn to promote nerve regeneration and enhance both nuclear and nerve survival. The purpose of this review is to discuss the potential role for gene therapy in treatment of the unsolved problem of vocal fold paralysis.
C1 Univ Michigan, Dept Neurol, Ann Arbor, MI 48109 USA.
   Univ Michigan, Dept Otolaryngol Head & Neck Surg, Ann Arbor, MI 48109 USA.
   Lakeshore ENT, Lakeshore Voice Ctr, St Clair Shores, MI USA.
   Univ Western Ontario, Dept Otolaryngol Head & Neck Surg, London, ON N6A 3K7, Canada.
RP Feldman, EL (reprint author), Univ Michigan, Dept Neurol, 5017 BSRB,109 Zina Pitcher Pl, Ann Arbor, MI 48109 USA.
RI Old, Matthew/E-3783-2011
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NR 66
TC 4
Z9 4
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD JUN
PY 2007
VL 116
IS 6
BP 441
EP 448
PG 8
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 181NW
UT WOS:000247444400009
PM 17672247
ER

PT J
AU Friedman, AD
   Dan, O
   Drazba, JA
   Lorenz, RR
   Strome, M
AF Friedman, Aaron D.
   Dan, Olivia
   Drazba, Judith A.
   Lorenz, Robert R.
   Strome, Marshall
TI Quantitative analysis of OX62-positive dendritic cell distribution in
   the rat laryngeal complex
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT 110th Annual Meeting of the
   American-Academy-of-Otolaryngology-Head-and-Neck-Surgery
CY SEP 17-20, 2006
CL Toronto, CANADA
SP Amer Acad Otolaryngol Head & Neck Surg
DE dendritic cell; larynx; OX62 antigen; rat; trachea
ID CARDIAC ALLOGRAFT SURVIVAL; IMMUNOCOMPETENT CELLS; ACUTE
   LARYNGOTRACHEITIS; INFLAMMATORY RESPONSE; BROAD-SPECTRUM; MUCOSA;
   TOLERANCE; REJECTION; DIFFERS; ANTIGEN
AB Objectives: Dendritic cells (DCs) are key instigators of rejection after transplantation. Their distribution has not been systematically characterized in all locations of the larynx and its surrounding tissues.
   Methods: Rat larynges were stained with monoclonal antibodies identifying DCs. These cells were then enumerated by a new combination of techniques including immunofluorescence, confocal microscopy, and imaging software.
   Results: The vast majority of DCs were located in the epithelium and subepithelium of the airway; the mean DC density ranged from 9 cells per square millimeter (0.2% of cells) to 645 cells per square millimeter (10.3% of cells). Their density in the epithelium was 3 to 11 times higher than that in the subepithelium. Non-airway sites (thyroid, parathyroid, muscle, fat) had mean DC densities varying from 3 cells per square millimeter (0.2%) to 57 cells per square millimeter (0.8%). No DCs were detected in cartilage.
   Conclusions: Dendritic cells are concentrated in the laryngotracheal epithelium and subepithelium and represent a much smaller proportion in the other sites studied. A baseline for laryngeal DC population studies has been established, and a computerized model for consistent quantitation using confocal microscopy has been developed. This unique method will serve as a foundation for investigating DC trafficking after rat laryngeal transplantation.
C1 Cleveland Clin, Head & Neck Inst, Cleveland, OH USA.
   Cleveland Clin, Lerner Res Inst, Cleveland, OH USA.
RP Lorenz, RR (reprint author), 9500 Euclid Ave,Desk A-71, Cleveland, OH 44195 USA.
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NR 24
TC 2
Z9 4
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD JUN
PY 2007
VL 116
IS 6
BP 449
EP 456
PG 8
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 181NW
UT WOS:000247444400010
PM 17672248
ER

EF