FN Thomson Reuters Web of Science™ VR 1.0 PT J AU Suzuki, H Tabata, T Koizumi, H Hohchi, N Takeuchi, S Kitamura, T Fujino, Y Ohbuchi, T AF Suzuki, Hideaki Tabata, Takahisa Koizumi, Hiroki Hohchi, Nobusuke Takeuchi, Shoko Kitamura, Takuro Fujino, Yoshihisa Ohbuchi, Toyoaki TI Prediction of Hearing Outcomes by Multiple Regression Analysis in Patients With Idiopathic Sudden Sensorineural Hearing Loss SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE idiopathic sudden sensorineural hearing loss; hearing outcome; prediction model; prognostic factor; multiple regression analysis ID HYPERBARIC-OXYGEN THERAPY; SALVAGE TREATMENT; PROGNOSIS; RECOVERY; EFFICACY; STEROIDS AB Objective: This study aimed to create a multiple regression model for predicting hearing outcomes of idiopathic suddensensorineural hearing loss (ISSNHL). Methods: The participants were 205 consecutive patients (205 ears) with ISSNHL (hearing level 40 dB, interval between onset and treatment 30 days). They received systemic steroid administration combined with intratympanic steroid injection. Data were examined by simple and multiple regression analyses. Three hearing indices (percentage hearing improvement, hearing gain, and posttreatment hearing level [HLpost]) and 7 prognostic factors (age, days from onset to treatment, initial hearing level, initial hearing level at low frequencies, initial hearing level at high frequencies, presence of vertigo, and contralateral hearing level) were included in the multiple regression analysis as dependent and explanatory variables, respectively. Results: In the simple regression analysis, the percentage [tearing improvement, hearing gain, and HLpost, showed significant correlation with 2, 5, and 6 of the 7 prognostic factors, respectively. The multiple correlation coefficients were 0.396, 0.503, and 0.714 for the percentage hearing improvement, hearing gain, and HLpost, respectively. Predicted values of HLpost calculated by the multiple regression equation were reliable with 70% probability with a 40-dB-width prediction interval. Conclusion: Prediction of HLpost by the multiple regression model may be useful to estimate the hearing prognosis of post ISSNHL. C1 [Suzuki, Hideaki; Tabata, Takahisa; Koizumi, Hiroki; Hohchi, Nobusuke; Takeuchi, Shoko; Kitamura, Takuro; Ohbuchi, Toyoaki] Univ Occupat & Environm Hlth, Sch Med, Dept Otorhinolaryngol Head & Neck Surg, Kitakyushu, Fukuoka 8078555, Japan. [Fujino, Yoshihisa] Univ Occupat & Environm Hlth, Sch Med, Dept Prevent Med & Community Hlth, Kitakyushu, Fukuoka 8078555, Japan. RP Suzuki, H (reprint author), Univ Occupat & Environm Hlth, Sch Med, Dept Otorhinolaryngol Head & Neck Surg, Yahatanishi Ku, 1-1 Iseigaoka, Kitakyushu, Fukuoka 8078555, Japan. EM suzuhyde@med.uoeh-u.ac.jp RI Fujino, Yoshihisa/F-3054-2010 OI Fujino, Yoshihisa/0000-0002-9126-206X CR Chao TK, 2006, AUDIOL NEURO-OTOL, V11, P331, DOI 10.1159/000095819 Cvorovic L, 2008, OTOL NEUROTOL, V29, P464, DOI 10.1097/MAO.0b013e31816fdcb4 Dispenza F, 2013, AM J OTOLARYNG, V34, P296, DOI 10.1016/j.amjoto.2012.12.010 Eisenman DJ, 2000, ARCH OTOLARYNGOL, V126, P1161 Harada Hirofumi, 2005, Int Tinnitus J, V11, P115 Kakehata S, 2011, AUDIOL NEURO-OTOL, V16, P191, DOI 10.1159/000320269 Kanzaki J, 1988, Acta Otolaryngol Suppl, V456, P31 Li LPH, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0035055 Li LPH, 2013, NEUROIMAGE, V64, P356, DOI 10.1016/j.neuroimage.2012.09.002 Masuda M, 2012, OTOL NEUROTOL, V33, P1142, DOI 10.1097/MAO.0b013e3182635417 Mori T, 2011, AURIS NASUS LARYNX, V38, P564, DOI 10.1016/j.anl.2010.12.018 Narozny W, 2006, ANN OTO RHINOL LARYN, V115, P553 Nosrati-Zarenoe R, 2012, OTOL NEUROTOL, V33, P523, DOI 10.1097/MAO.0b013e31824b78da Ohashi T, 2012, ACTA OTO-LARYNGOL, V132, P133, DOI 10.3109/00016489.2011.633228 Suzuki H, 2003, ACTA OTO-LARYNGOL, V123, P46, DOI 10.1080/0036554021000028082 Suzuki H, 2011, EUR ARCH OTO-RHINO-L, V268, P497, DOI 10.1007/s00405-010-1400-2 Suzuki H, 2012, LARYNGOSCOPE, V122, P1154, DOI 10.1002/lary.23245 Suzuki H, 2008, AURIS NASUS LARYNX, V35, P192, DOI 10.1016/j.anl.2007.06.003 Ulu S, 2013, OTOL NEUROTOL, V34, P1400, DOI 10.1097/MAO.0b013e31829b57df Wang CT, 2009, EAR HEARING, V30, P110, DOI 10.1097/AUD.0b013e318192655e WILSON WR, 1980, ARCH OTOLARYNGOL, V106, P772 Yoshida T, 2008, LARYNGOSCOPE, V118, P1433, DOI 10.1097/MLG.0b013e318172ef85 NR 22 TC 2 Z9 2 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD DEC PY 2014 VL 123 IS 12 BP 821 EP 825 DI 10.1177/0003489414538606 PG 9 WC Otorhinolaryngology SC Otorhinolaryngology GA AU0KC UT WOS:000345310700001 PM 24944278 ER PT J AU Kopelovich, JC Baker, MS Potash, A Desai, L Allen, RC Chang, EH AF Kopelovich, Jonathan C. Baker, Meredith S. Potash, Andrea Desai, Lajja Allen, Richard C. Chang, Eugene H. TI The Hybrid Lid Crease Approach to Address Lateral Frontal Sinus Disease With Orbital Extension SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE frontal sinus; endoscopic; lid crease; inverted papilloma; mucocele ID SINONASAL INVERTED PAPILLOMA; OSTEOPLASTIC FLAP; MANAGEMENT; SURGERY; MUCOCELES; METAANALYSIS; ERA AB Objective: This study aimed to describe the hybrid lid crease approach in conjunction with functional endoscopic sinus surgery (FESS) for lateral frontal sinus disease with orbital extension. Study Design: Retrospective case review. Methods: Patients undergoing hybrid lid crease approach with FESS for frontal sinus disease were reviewed retrospectively. Surgical indications consisted of inverting papilloma with extension into the frontal sinus (n = 1) and frontal sinus mucocele (n = 2). Inclusion criteria included presence of disease in the lateral frontal sinus with extension into the orbital space and erosion of the superior orbital rim. Preoperative and postoperative parameters included complete ophthalmologic exam, endoscopic exam, and computed tomography scan. Results: We were able to access the frontal sinus and orbit in all 3 cases and address sinus pathology of the lateral frontal sinus and orbit using the lid crease approach with FESS. All patients had improvement in ophthalmologic symptoms and interval disease resolution and were satisfied with their postoperative lid crease incision. Conclusion: The lid crease approach offers direct access to the frontal sinus with minimal dissection through a well-hidden incision. In our case series of lateral frontal sinus pathology with orbital extension, the hybrid lid crease approach with FESS allowed complete eradication of disease without recurrence. C1 [Kopelovich, Jonathan C.; Chang, Eugene H.] Univ Iowa Hosp & Clin, Dept Otorhinolaryngol Head & Neck Surg, Iowa City, IA 52242 USA. [Baker, Meredith S.; Potash, Andrea; Allen, Richard C.] Univ Iowa Hosp & Clin, Dept Ophthalmol & Visual Sci, Iowa City, IA 52242 USA. [Desai, Lajja] Univ Iowa Hosp & Clin, Roy J & Lucille A Carver Coll Med, Iowa City, IA 52242 USA. RP Chang, EH (reprint author), Univ Iowa Hosp & Clin, Dept Otorhinolaryngol Head & Neck Surg, 200 Hawkins Dr,21200 PFP, Iowa City, IA 52242 USA. EM Eugene-Chang@uiowa.edu FU NIH [DE021413-01A1]; National Center for Research Resources, National Institutes of Health (NIH) [KL2RR024980] FX The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: Supported by the NIH (DE021413-01A1). This publication was also made possible by Grant No. KL2RR024980 from the National Center for Research Resources, a part of the National Institutes of Health (NIH). CR Anand VK, 2005, AM J RHINOL, V19, P406 Batra PS, 2005, AM J RHINOL, V19, P435 Busquets JM, 2006, OTOLARYNG HEAD NECK, V134, P476, DOI 10.1016/j.otohns.2005.11.038 Chiu AG, 2004, AM J RHINOL, V18, P83 Courson AM, 2014, LARYNGOSCOPE, V124, P378, DOI 10.1002/lary.24309 Hahn S, 2009, AMJ RHINOL ALLERGY, V23, P342, DOI 10.2500/ajra.2009.23.3327 Isa AY, 2011, J LARYNGOL OTOL, V125, P162, DOI 10.1017/S0022215110002288 Jacobs JB, 1997, LARYNGOSCOPE, V107, P1, DOI 10.1097/00005537-199711001-00001 KENNEDY DW, 1989, LARYNGOSCOPE, V99, P885 Knipe TA, 2007, AM J RHINOL, V21, P100, DOI 10.2500/ajr.2007.21.2985 Kuhn FA, 2001, OTOLARYNG CLIN N AM, V34, P59, DOI 10.1016/S0030-6665(05)70295-4 Lee JM, 2011, CURR OPIN OTOLARYNGO, V19, P11, DOI 10.1097/MOO.0b013e3283419453 Lombardi D, 2011, HEAD NECK-J SCI SPEC, V33, P1154, DOI 10.1002/hed.21589 Sautter NB, 2008, OTOLARYNG HEAD NECK, V139, P570, DOI 10.1016/j.otohns.2008.07.004 Walgama E, 2012, LARYNGOSCOPE, V122, P1205, DOI 10.1002/lary.23275 Weber R, 2001, LARYNGOSCOPE, V111, P137, DOI 10.1097/00005537-200101000-00024 NR 16 TC 0 Z9 0 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD DEC PY 2014 VL 123 IS 12 BP 826 EP 830 DI 10.1177/0003489414538767 PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA AU0KC UT WOS:000345310700002 PM 24944279 ER PT J AU Torres, AC Guerrero, JS Silva, HC AF Torres, Arnulfo C. Guerrero, Jaime S. Silva, Helen C. TI A Modified Transoral Approach for Carotid Artery Type Eagle Syndrome: Technique and Outcomes SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE Eagle's syndrome; styloid process elongation; neck pain; surgical treatment; intraoral approach ID ELONGATED STYLOID PROCESS; SURGICAL-TREATMENT; INTRAORAL APPROACH; STYLOHYOID SYNDROME; DIAGNOSIS AB Objective: This article aimed to summarize our clinical experience with a standardized tonsil-sparing transoral surgical approach used for treatment of styloid process-carotid artery Eagle's syndrome. Methods: Eleven consecutive patients, from 2007 to 2013, underwent surgical treatment to remove elongated styloid apophyses transorally. Outcomes were assessed in terms of intraoperative and postoperative complications and patients' evolution. Results: No patient experienced any intraoperative or postoperative complications. All patients have been followed up to present and 10 of them have shown complete relief of the symptoms and improvement of functional ability. Conclusion: The tonsil-sparing transoral surgical approach described is suitable for treating patients with elongated styloid apophyses. C1 [Torres, Arnulfo C.; Silva, Helen C.] Univ Cartagena, Fac Med, Hosp Univ Caribe, Dept Otolaryngol, Cartagena, Colombia. [Guerrero, Jaime S.] Univ Cartagena, Fac Dent, Div Stomatol & Oral Surg, Cartagena, Colombia. RP Torres, AC (reprint author), Univ Cartagena, Fac Med, Hosp Univ Caribe, Dept Otolaryngol, Cartagena, Colombia. EM t_arnulfo@hotmail.com CR Arkuszewski Piotr, 2009, Otolaryngol Pol, V63, P162, DOI 10.1016/S0030-6657(09)70099-X Arkuszewski P, 2010, POLSKI PRZEGLAD CHIR, V82, P626, DOI 10.2478/v10035-010-0095-9 Baharudin Abdullah, 2012, Acta Inform Med, V20, P133, DOI 10.5455/aim.2012.20.133-135 Balbuena L, 1997, SOUTHERN MED J, V90, P331, DOI 10.1097/00007611-199703000-00014 Beder E, 2005, J ORAL MAXIL SURG, V63, P1742, DOI 10.1016/j.joms.2005.08.017 Ceylan A, 2008, SKULL BASE-INTERD AP, V18, P289, DOI 10.1055/s-0028-1086057 Chrcanovic Bruno Ramos, 2009, Oral Maxillofac Surg, V13, P145, DOI 10.1007/s10006-009-0164-6 Costantinides F, 2013, CRANIO, V31, P56 Carvalho ACGD, 2009, BRIT J ORAL MAX SURG, V47, P153, DOI 10.1016/j.bjoms.2008.07.195 Diamond LH, 2001, J ORAL MAXIL SURG, V59, P1420, DOI 10.1053/joms.2001.28276 EAGLE WW, 1949, ARCH OTOLARYNGOL, V49, P490 Ghosh Lal M., 1999, Auris Nasus Larynx, V26, P169, DOI 10.1016/S0385-8146(98)00079-0 Han Min Kyu, 2013, Korean J Pain, V26, P169, DOI 10.3344/kjp.2013.26.2.169 Hossein R, 2010, J CRANIOFAC SURG, V21, P275, DOI 10.1097/SCS.0b013e3181c5a444 Khandelwal Suneet, 2011, Saudi Dent J, V23, P211, DOI 10.1016/j.sdentj.2010.10.006 Kim E, 2008, ENT-EAR NOSE THROAT, V87, P631 Martins WD, 2013, CRANIO, V31, P226 Maru Y K, 2003, Indian J Otolaryngol Head Neck Surg, V55, P87, DOI 10.1007/BF02974610 Mendelsohn AH, 2006, OTOLARYNG HEAD NECK, V134, P389, DOI 10.1016/j.otohns.2005.10.046 MONTALBETTI L, 1995, CEPHALALGIA, V15, P80, DOI 10.1046/j.1468-2982.1995.015002080.x Mortellaro C, 2002, J CRANIOFAC SURG, V13, P755, DOI 10.1097/00001665-200211000-00007 Murtagh RD, 2001, AM J NEURORADIOL, V22, P1401 Naik Sudhir M, 2011, Oman Med J, V26, P122, DOI 10.5001/omj.2011.30 Pereira FL, 2007, J ORAL MAXIL SURG, V65, P1346, DOI 10.1016/j.joms.2006.07.020 Perello J, 1995, ACTA ORL IMEROAMERIC, V6, P441 Petrovic B, 2008, SRP ARK CELOK LEK, V136, P667, DOI 10.2298/SARH0812667P Prasad KC, 2002, J ORAL MAXIL SURG, V60, P171, DOI 10.1053/joms.2002.29814 Prokopakis Emmanuel P, 2008, Head Face Med, V4, P20, DOI 10.1186/1746-160X-4-20 Slavin KV, 2002, J NEUROSURG, V97, P216, DOI 10.3171/jns.2002.97.1.0216 STRAUSS M, 1985, LARYNGOSCOPE, V95, P976 Valerio CS, 2012, J CRANIOFAC SURG, V23, pE138, DOI 10.1097/SCS.0b013e31824cdb46 Walner DL, 2013, ANN OTO RHINOL LARYN, V122, P277 Windfuhr JP, 2013, ANN OTOL RHINOL LARY, V12 Yavuz H, 2011, J OTOLARYNGOL-HEAD N, V40, P86, DOI 10.2310/7070.2011.060089 NR 34 TC 1 Z9 1 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD DEC PY 2014 VL 123 IS 12 BP 831 EP 834 DI 10.1177/0003489414538770 PG 4 WC Otorhinolaryngology SC Otorhinolaryngology GA AU0KC UT WOS:000345310700003 PM 24944271 ER PT J AU Nogueira, C Ma, F Kaushal, S Banerjee, A AF Nogueira, Claudia Ma, Fatima Kaushal, Sushila Banerjee, Anil TI The Swing-Door Island Flap Canalplasty Technique SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE canalplasty; chronic refractory otitis externa; external auditory canal ID CHRONIC OTITIS-EXTERNA; THICKNESS SKIN-GRAFTS; SURGICAL-TREATMENT; ACQUIRED ATRESIA; SURGERY; MEATOPLASTY; MANAGEMENT; FIBROSIS; STENOSIS AB Objective: This article describes a new canalplasty technique for the treatment of symptoms resulting from chronic refractory otitis externa. Methods: We report on our experience using a swing-door island flap and a periosteal flap. Thirteen patients underwent treatment and a total of 19 ears were operated on. The range of preoperative symptoms was 3 to 22 years (mean length of symptoms = 12 years). Results: The postoperative course in all the patients showed this to be a satisfactory treatment with no recurrence of symptoms. Conclusion: The swing-door island flap canalplasty technique is an effective surgical treatment in patients with refractory otitis externa. C1 [Nogueira, Claudia; Ma, Fatima; Kaushal, Sushila; Banerjee, Anil] Univ Hosp Leicester, ENT Dept, Leicester, Leics, England. RP Nogueira, C (reprint author), Univ Leicester, Hosp Infirm Sq, Directorate Otorhinolaryngol & Head & Neck Surg, Leicester LE1 5WW, Leics, England. EM claudianogueira1@gmail.com CR AGIUS AM, 1992, CLIN OTOLARYNGOL, V17, P150, DOI 10.1111/j.1365-2273.1992.tb01063.x BANERJEE AR, 1995, CLIN OTOLARYNGOL, V20, P150, DOI 10.1111/j.1365-2273.1995.tb00033.x BELL DR, 1988, J OTOLARYNGOL, V17, P19 CHANG SO, 1994, LARYNGOSCOPE, V104, P606 Davis E D, 1920, Proc R Soc Med, V13, P65 Dhooge IJM, 1999, CLIN OTOLARYNGOL, V24, P58, DOI 10.1046/j.1365-2273.1999.00216.x El-Sayed Y, 1998, J LARYNGOL OTOL, V112, P145 KATZKE D, 1982, ARCH OTOLARYNGOL, V108, P779 Kaushik V, 2010, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD004740.pub2 Kumar BN, 1997, J LARYNGOL OTOL, V111, P1126 Kumar PJ, 2007, J LARYNGOL OTOL, V121, P1, DOI 10.1017/S0022215106003574 Lavy J, 2001, J LARYNGOL OTOL, V115, P270 LEEK JH, 1967, ARCHIV OTOLARYNGOL, V85, P367 MARTINHIRSCH DP, 1993, J LARYNGOL OTOL, V107, P1029 MCCARY WS, 1995, AM J OTOL, V16, P801 MOORE GF, 1984, LARYNGOSCOPE, V94, P1117 PAPARELL.MM, 1966, LARYNGOSCOPE, V76, P232 PAPARELL.MM, 1966, LARYNGOSCOPE, V76, P1136 PAPARELLA MM, 1981, OTOLARYNG HEAD NECK, V89, P440 Parisier SC, 1996, OTOLARYNG CLIN N AM, V29, P867 Parisier SC, 1999, OTOLARYNG CLIN N AM, V32, P457, DOI 10.1016/S0030-6665(05)70145-6 PETERKIN GA, 1974, J LARYNGOL OTOL, V88, P15, DOI 10.1017/S0022215100078294 Potter CPS, 2012, J LARYNGOL OTOL, V126, P1016, DOI 10.1017/S0022215112001703 PROUD GO, 1966, ARCHIV OTOLARYNGOL, V83, P436 Roland PS, 2001, EAR NOSE THROAT J S6, V80, P12 RUSSELL JD, 1993, J LARYNGOL OTOL, V107, P898 SMITH IM, 1990, CLIN OTOLARYNGOL, V15, P155, DOI 10.1111/j.1365-2273.1990.tb00449.x SOLIMAN T, 1980, J LARYNGOL OTOL, V94, P549, DOI 10.1017/S0022215100089234 SPECTOR GJ, 1979, LARYNGOSCOPE, V89, P674 TOS M, 1986, AM J OTOL, V7, P365 TOS M, 1979, ORL J OTO-RHINO-LARY, V41, P85 NR 31 TC 0 Z9 0 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD DEC PY 2014 VL 123 IS 12 BP 835 EP 839 DI 10.1177/0003489414538935 PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA AU0KC UT WOS:000345310700004 PM 24944277 ER PT J AU Zeitels, SM Burns, JA AF Zeitels, Steven M. Burns, James A. TI Oncologic Efficacy of Angiolytic KTP Laser Treatment of Early Glottic Cancer SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE glottic cancer; vocal cord cancer; vocal fold cancer; KTP laser; voice surgery; voice preservation; phonomicrosurgery ID VOCAL FOLD; CLINICAL EXPERIENCE; LARYNGEAL-CANCER; IN-SITU; SURGERY; CARCINOMA; VOICE; RADIOTHERAPY; CO2-LASER AB Objective: Angiolytic laser removal of early glottic cancer with ultra-narrow margins was reported in a pilot study 5 years ago as an innovative surgical treatment strategy to better preserve vocal function. Subsequently, in a cohort of > 90 patients, enhanced voice outcomes were achieved and there was diminished need for post-treatment phonosurgical reconstruction. However, the initial pilot study examining oncologic efficacy had a limited number of patients and most did not have 3-year follow-up. Consequently, further analysis of the oncologic efficacy is valuable. Method: Retrospective review. Results: One hundred seventeen patients (T1a-71, T1b-11, T2a-10, T2b-25) underwent potassium-titanyl-phosphate (KTP) laser treatment of early glottic cancer with a minimum 3-year follow-up (average = 53 months). The "b" designation delineated bilateral disease. Disease control for T1 and T2 lesions was 96% (79/82) and 80% (28/35), respectively. All 10 recurrences were treated with radiotherapy. Fifty percent (5/10) were controlled with radiotherapy, and the other 5 died of disease. Larynx preservation and survival were achieved in 99% (81/82) with T1 disease and 89% (31/35) with T2 disease. Conclusion: This investigation provides further evidence that angiolytic KTP laser removal of early glottic cancer with ultra-narrow margins is an effective oncologic treatment strategy. Radiotherapy was preserved for future use in more than 90% of patients. Since a majority of patients are referred by an otolaryngologist to undergo treatment of early glottic cancer with radiotherapy, this investigation provides compelling information to reappraise this paradigm. C1 [Zeitels, Steven M.; Burns, James A.] Harvard Univ, Sch Med, Dept Surg, Boston, MA 02115 USA. [Zeitels, Steven M.; Burns, James A.] Massachusetts Gen Hosp, Ctr Laryngeal Surg & Voice Rehabil, Boston, MA 02114 USA. RP Zeitels, SM (reprint author), Massachusetts Gen Hosp, Ctr Laryngeal Surg & Voice Rehabil, One Bowdoin Sq,11th Floor, Boston, MA 02114 USA. EM zeitels.steven@mgh.harvard.edu FU National Philanthropic Trust; 'V' Foundation; Eugene B. Casey Foundation; Voice Health Institute FX The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported in part by the following nonprofit foundations: National Philanthropic Trust, 'V' Foundation, Eugene B. Casey Foundation, and the Voice Health Institute. CR Al-Mamgani A, 2013, CLIN OTOLARYNGOL, V38, P306, DOI 10.1111/coa.12139 ANDERSON R R, 1983, Lasers in Surgery and Medicine, V3, P211 Anderson R R, 1981, Lasers Surg Med, V1, P263 Barbu AM, 2013, ANN OTO RHINOL LARYN, V122, P235 Broadhurst MS, 2007, LARYNGOSCOPE, V117, P220, DOI 10.1097/mlg.0b013e31802b5c1c Burns JA, 2004, LARYNGOSCOPE, V114, P1864, DOI 10.1097/00005537-200410000-00035 Colden Darryl, 2001, Annals of Otology Rhinology and Laryngology, V110, P293 DESANTO LW, 1974, CAN J OTOLARYNGOL, V3, P552 FOLKMAN J, 1971, NEW ENGL J MED, V285, P1182 Follcman J, 1985, ADV CANCER RES, V43, P175 Fraenkel B, 1886, ARCH KLIN CHIR, V12, P283 Friedman AD, 2013, ANN OTO RHINOL LARYN, V122, P151 HIRANO M, 1985, ANN OTO RHINOL LARYN, V94, P232 JAKO GJ, 1972, LARYNGOSCOPE, V82, P2204, DOI 10.1288/00005537-197212000-00009 Jako G J, 1978, Int Adv Surg Oncol, V1, P265 Jako GJ, 1966, ENDOLARYNGEAL MICROD Kleinsasser O, 1968, MICROLARYNGOSCOPY EN, P103 Kleinsasser O, 1968, MICROLARYNGOSCOPY EN Lynch RC, 1920, T AM LARYNGOL ASS, V40, P119 Mehta DD, 2010, ANN OTO RHINOL LARYN, V119, P1 New GB, 1941, MAYO CLIN P, V16, P411 Piazza C, 2007, ARCH OTOLARYNGOL, V133, P1037, DOI 10.1001/archotol.133.10.1037 Steiner W, 1994, P 2 WORLD C LAR CANC, P369 STRONG MS, 1972, ANN OTO RHINOL LARYN, V81, P791 STRONG MS, 1975, LARYNGOSCOPE, V85, P1286, DOI 10.1288/00005537-197508000-00003 Tucker GF, 1971, HUMAN LARYNX CORONAL VAUGHAN CW, 1978, LARYNGOSCOPE, V88, P1399 VAUGHAN CW, 1978, AM J SURG, V136, P490, DOI 10.1016/0002-9610(78)90267-2 Zeitels SM, 2001, ATLAS PHONOMICROSURG, P177 Zeitels SM, 2006, ANN OTO RHINOL LARYN, V115, P535 Zeitels SM, 1996, AM J SURG, V172, P704, DOI 10.1016/S0002-9610(96)00295-4 Zeitels SM, 2002, ANN OTOL RHINOL S190, V111, P1 Zeitels SM, 2004, OTOLARYNG CLIN N AM, V37, P627, DOI 10.1016/j.otc.2004.02.001 Zeitels SM, 2004, ANN M AM BRONCH ES A Zeitels SM, 2003, ANN OTO RHINOL LARYN, V112, P180 Zeitels SM, 2001, LARYNGOSCOPE, V111, P1862, DOI 10.1097/00005537-200110000-00036 Zeitels Steven M, 2007, Curr Opin Otolaryngol Head Neck Surg, V15, P394, DOI 10.1097/MOO.0b013e3282f1fbb2 Zeitels SM, 2008, ANN OTOL RHINOL S199, V117, P1 ZEITELS SM, 1995, LARYNGOSCOPE, V105, P1, DOI 10.1288/00005537-199503001-00001 Zeitels SM, 2006, ANN OTO RHINOL LARYN, V115, P679 Zeitels SM, 2007, ANN OTO RHINOL LARYN, V116, P317 ZEITELS SM, 1991, OTOLARYNG HEAD NECK, V105, P478 NR 42 TC 0 Z9 0 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD DEC PY 2014 VL 123 IS 12 BP 840 EP 846 DI 10.1177/0003489414538936 PG 7 WC Otorhinolaryngology SC Otorhinolaryngology GA AU0KC UT WOS:000345310700005 PM 24970297 ER PT J AU Berlucchi, M Barbieri, D Garofolo, S Stefini, S Peretti, G AF Berlucchi, Marco Barbieri, Diego Garofolo, Sabrina Stefini, Stefania Peretti, Giorgio TI Case Report: Pharyngolaryngeal Stenosis in a Child Due to Caustic Ingestion Treated With Transoral CO2 Laser Microsurgery SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE caustic ingestion; laryngeal stenosis; pharyngeal stenosis; CO2 laser; endoscopic surgery ID CORROSIVE ESOPHAGEAL BURNS; POISON CONTROL CENTERS; UPPER AIRWAY; MANAGEMENT; STRICTURE; EXPOSURES; INJURIES; LESIONS; LARYNX; TRACT AB Accidental caustic ingestion occurs mainly in the 2- to 3-year-old age group. Up to 33% of patients develop long-term complications that principally involve the gastroesophageal tract, whereas their occurrence at the level of pharyngeal and laryngeal structures is less frequent. When present, strictures are the main disorders that can be observed. In this pathological situation, surgery is the treatment of choice, and several procedures have been described. We report the,history of a 3-year-old boy affected by pharyngolaryngeal stenosis due to accidental caustic ingestion. After careful diagnosis, the child underwent surgery by transoral CO2 laser. The patient had immediate improvement and restarted oral feeding I day after the surgical procedure. An analysis of diagnosis and treatment of this long-term complication is also presented. C1 [Berlucchi, Marco; Stefini, Stefania] Spedali Civil Brescia, Dept Pediat Otorhinolaryngol, I-25123 Brescia, Italy. [Barbieri, Diego] Univ Brescia, Dept Otorhinolaryngol, Brescia, Italy. [Garofolo, Sabrina; Peretti, Giorgio] Univ Genoa, Dept Otolaryngol, Genoa, Italy. RP Berlucchi, M (reprint author), Spedali Civil Brescia, Dept Pediat Otorhinolaryngol, Piazza Spedali Civili 1, I-25123 Brescia, Italy. EM marco.berlucchi@tin.it CR Andiran N, 2004, TURKISH J PEDIATR, V46, P147 Andrews TM, 1997, CURR OPIN OTOLARYNGO, V5, P362, DOI 10.1097/00020840-199712000-00007 Arici MA, 2012, HUM EXP TOXICOL, V31, P533, DOI 10.1177/0960327111412803 Balachandran R, 2011, Med J Malaysia, V66, P152 Bronstein AC, 2009, CLIN TOXICOL, V47, P911, DOI 10.3109/15563650903438566 Cibisev A, 2007, Prilozi, V28, P171 Denney W, 2012, PEDIATR EMERG CARE, V28, P731, DOI 10.1097/PEC.0b013e31826248eb EDGERTON MT, 1952, SURGERY, V31, P239 Elshabrawi M, 2011, EXPERT REV GASTROENT, V5, P637, DOI [10.1586/egh.11.49, 10.1586/EGH.11.49] Friedman E M, 1984, Emerg Med Clin North Am, V2, P77 GAUDREAULT P, 1983, PEDIATRICS, V71, P767 GREGOR RT, 1988, J OTOLARYNGOL, V17, P16 Gunel E, 2002, PEDIATR SURG INT, V18, P24, DOI 10.1007/s003830200005 Hatta C, 1999, Nihon Jibiinkoka Gakkai Kaiho, V102, P976 HAWKINS DB, 1980, LARYNGOSCOPE, V90, P98, DOI 10.1288/00005537-198001000-00012 Kay M, 2009, CURR OPIN PEDIATR, V21, P651, DOI 10.1097/MOP.0b013e32832e2764 KIKENDALL JW, 1991, GASTROENTEROL CLIN N, V20, P847 KREY H, 1952, Acta Otolaryngol Suppl, V102, P1 MCLEAR PW, 1991, AM J OTOLARYNG, V12, P76, DOI 10.1016/0196-0709(91)90040-M Meredith W, 1988, J TRAUMA, V28, P1173 MOORE WR, 1986, CLIN PEDIATR, V25, P192, DOI 10.1177/000992288602500404 MOULIN D, 1985, J PEDIATR-US, V106, P408, DOI 10.1016/S0022-3476(85)80665-X Mullen MH, 2006, POISONING DRUG OVERD, P88 Ochi K, 1996, ACTA OTO-LARYNGOL, P116 Saetti R, 2003, ANN OTO RHINOL LARYN, V112, P29 Salzman M, 2007, EMERG MED CLIN N AM, V25, P459, DOI 10.1016/j.emc.2007.02.007 Sawalha AF, 2008, ISR MED ASSOC J, V10, P757 SCHILD JA, 1985, LARYNGOSCOPE, V95, P1199 SCOTT JC, 1992, LARYNGOSCOPE, V102, P1 Shikowitz MJ, 1996, LARYNGOSCOPE, V106, P1, DOI 10.1097/00005537-199602001-00001 Temir ZG, 2005, SURG TODAY, V35, P617, DOI 10.1007/s00595-004-3005-0 Thirlwall AS, 2001, INT J PEDIATR OTORHI, V59, P129, DOI 10.1016/S0165-5876(01)00461-X Tufekci IB, 2004, HUM EXP TOXICOL, V23, P347, DOI 10.1191/0960327104ht460oa Villa Antoine, 2008, Rev Prat, V58, P825 Wheeler DS, 2003, PEDIATR PULM, V35, P323, DOI 10.1002/ppul.10248 NR 35 TC 0 Z9 0 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD DEC PY 2014 VL 123 IS 12 BP 847 EP 851 DI 10.1177/0003489414538938 PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA AU0KC UT WOS:000345310700006 PM 24944275 ER PT J AU Horn, DL DeMarre, K Parikh, SR AF Horn, David L. DeMarre, Kim Parikh, Sanjay R. TI Interarytenoid Sodium Carboxymethylcellulose Gel Injection for Management of Pediatric Aspiration SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE posterior laryngeal cleft; aspiration; carboxymethylcellulose sodium; dysphagia; interarytenoid injection; Radiesse ID TYPE-1 LARYNGEAL CLEFT; PHARYNGEAL DYSFUNCTION; DIAGNOSIS; PHENOTYPES; DYSPHAGIA AB Objective: This study aimed to investigate the role of interarytenoid injection laryngoplasty (IL) for the management of pediatric aspiration. Methods: Medical records of 30 patients, 9 female, with radiographically confirmed chronic aspiration who underwent intraoperative IL were retrospectively reviewed. Clinical improvement was defined as successful advancement of feeds to thinner consistencies. Results: Clinical improvement was observed in 57% of patients. Six children with type I posterior laryngeal cleft (PLC-1) were not significantly more likely to show improvement compared to the children without PLC-1. Type 1 posterior laryngeal cleft was associated with older age and higher prevalence of neurodevelopmental risk factors relative to absence of PLC-1. Patients with PLC-1 were more likely than noncleft patients to show recurrence of symptoms after initial improvement with IL. Five patients underwent endoscopic repair. Repair was successful in 3 patients who improved after IL but not in 2 patients who did not improve after IL. Conclusion: Chronic aspiration can improve after IL even in patients with normal anatomy. Injection laryngoplasty can be performed to improve selection of PLC-1 patients for definitive endoscopic repair. Further prospective research, with a randomized control group, is needed to understand whether interarytenoid incompetence plays a role in some patients with chronic aspiration, who do not have a PLC-1. C1 [Horn, David L.; Parikh, Sanjay R.] Univ Washington, Seattle Childrens Hosp, Sch Med, Dept Otolaryngol Head & Neck Surg,Div Pediat Otol, Seattle, WA 98105 USA. [DeMarre, Kim] Seattle Childrens Hosp, Dept Speech & Language, Seattle, WA 98105 USA. RP Horn, DL (reprint author), Seattle Childrens Hosp, Dept Otolaryngol Head & Neck Surg, 800 Sand Point Way NE, Seattle, WA 98105 USA. EM david.horn@seattlechildrens.org CR Al-Kateb H, 2014, AM J MED GENET A, V164, P1118, DOI 10.1002/ajmg.a.36401 BENJAMIN B, 1989, ANN OTO RHINOL LARYN, V98, P417 Chien W, 2006, INT J PEDIATR OTORHI, V70, P2073, DOI 10.1016/j.ijporl.2006.07.021 Cohen MS, 2011, OTOLARYNG HEAD NECK, V144, P789, DOI 10.1177/0194599810395082 Inder TE, 1998, PEDIATR NEUROL, V19, P222, DOI 10.1016/S0887-8994(98)00043-5 Kennedy CA, 2000, ANN OTO RHINOL LARYN, V109, P991 Lefton-Greif MA, 2006, PEDIATR PULM, V41, P1040, DOI 10.1002/ppul.20488 Mangat HS, 2012, OTOLARYNG HEAD NECK, V146, P764, DOI 10.1177/0194599811434004 MBONDA E, 1995, J PEDIATR-US, V126, P923, DOI 10.1016/S0022-3476(95)70209-1 Mefford HC, 2008, NEW ENGL J MED, V359, P1685, DOI 10.1056/NEJMoa0805384 NAKAHARA S, 1995, INT J PEDIATR OTORHI, V32, P187, DOI 10.1016/0165-5876(95)01131-T Ondrey F, 2000, AM J MED GENET, V94, P64, DOI 10.1002/1096-8628(20000904)94:1<64::AID-AJMG13>3.0.CO;2-D Parsons DS, 1998, LARYNGOSCOPE, V108, P403, DOI 10.1097/00005537-199803000-00017 Thach Bradley T., 2001, American Journal of Medicine, V111, p69S Watters K, 2003, INT J PEDIATR OTORHI, V67, P591, DOI 10.1016/S0165-5876(03)00058-2 NR 15 TC 0 Z9 0 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD DEC PY 2014 VL 123 IS 12 BP 852 EP 858 DI 10.1177/0003489414539129 PG 7 WC Otorhinolaryngology SC Otorhinolaryngology GA AU0KC UT WOS:000345310700007 PM 24963090 ER PT J AU Oonk, AMM Ekker, MS Huygen, PLM Kunst, HPM Kremer, H Schelhaas, JJ Pennings, RJE AF Oonk, Anne M. M. Ekker, Merel S. Huygen, Patrick L. M. Kunst, Henricus P. M. Kremer, Hannie Schelhaas, Jurgen J. Pennings, Ronald J. E. TI Intrafamilial Variable Hearing Loss in TRPV4 Induced Spinal Muscular Atrophy SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE hereditary hearing loss; spinal muscular atrophy; TRPV4; variability ID MUTATIONS; CHANNELOPATHIES; GENE AB Objective: Mutations in the transient receptor potential vanilloid 4 gene (TRPV4) can induce a great diversity of neuropathies. Together with these neuropathies, hearing loss can occur. This study is focused on providing an audiometric phenotype description of a Dutch family with spinal muscular atrophy caused by a mutation in TRPV4. Methods: A neurological examination was repeated and pure tone and speech audiometry were performed. Results: A large variety in neurological symptoms as well as variation in audiometric characteristics was observed. The severity of hearing loss is mild to moderate and the audiogram configuration is highly variable. The hearing loss of these patients has a progressive nature in general. The frequencies that deteriorate significantly differ between family members. When compared to presbyacusis patients, speech recognition scores of patients with a TRPV4 mutation are not clearly different. Conclusion: The function of TRPV4 in the inner ear is still elusive but it is suggested that TRPV4 is required for maintenance of cochlear function in stress conditions, like acoustic injury. We can neither confirm nor reject this based on the results obtained in this family. Therefore, one might consider advising patients with a TRPV4 mutation to avoid exposure to environmental influences such as noise exposure. C1 [Oonk, Anne M. M.; Ekker, Merel S.; Huygen, Patrick L. M.; Kunst, Henricus P. M.; Kremer, Hannie; Pennings, Ronald J. E.] Radboud Univ Nijmegen, Med Ctr, Dept Otorhinolaryngol Hearing & Genes, NL-6500 HB Nijmegen, Netherlands. [Oonk, Anne M. M.; Huygen, Patrick L. M.; Kunst, Henricus P. M.; Pennings, Ronald J. E.] Radboud Univ Nijmegen, Med Ctr, Donders Inst Brain Cognit & Behav, NL-6500 HB Nijmegen, Netherlands. [Kremer, Hannie] Radboud Univ Nijmegen, Med Ctr, Nijmegen Ctr Mol Life Sci, NL-6500 HB Nijmegen, Netherlands. [Schelhaas, Jurgen J.] Kempenhaege, Expertise Ctr Epileptol Sleep Med & Neurocognit, Heeze, Netherlands. RP Oonk, AMM (reprint author), Radboud Univ Nijmegen, Med Ctr, Dept Otorhinolaryngol Hearing & Genes, Postbus 9101, NL-6500 HB Nijmegen, Netherlands. EM Anne.Oonk@Radboudumc.nl FU Heinsius Houbolt Foundation; Oticon Foundation [09-3742]; ZON MW [40-00812-98-09047, 90700388] FX The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was funded by the Heinsius Houbolt Foundation to H.K., the Oticon Foundation (09-3742) to H.K., and ZON MW (to H.K.: 40-00812-98-09047; to R.J.E.P.: 90700388). CR Auer-Grumbach M, 2010, NAT GENET, V42, P160, DOI 10.1038/ng.508 Bienfait HME, 2006, J NEUROL, V253, P1572, DOI 10.1007/s00415-006-0260-6 BOLTSHAUSER E, 1989, J MED GENET, V26, P105, DOI 10.1136/jmg.26.2.105 Davis A, 2007, HEALTH TECHNOL ASSES, V11, P1 De Leenheer EMR, 2002, ANN OTO RHINOL LARYN, V111, P267 Deng HX, 2010, NAT GENET, V42, P165, DOI 10.1038/ng.509 FLEURY P, 1985, J NEUROL NEUROSUR PS, V48, P1037, DOI 10.1136/jnnp.48.10.1037 Friedman TB, 2003, EAR HEARING, V24, P289, DOI 10.1097/01.AUD.0000079804.00047.CE Giacomello M, 2011, CELL CALCIUM, V50, P569, DOI 10.1016/j.ceca.2011.09.004 Kalampokas E, 2012, ISRN OBSTET GYNECOL, V2012, DOI [10.5402/2012/264918, DOI 10.5402/2012/264918] Karasawa T, 2008, J CELL SCI, V121, P2871, DOI 10.1242/jcs.023705 Landoure G, 2010, NAT GENET, V42, P170, DOI 10.1038/ng.512 Lee JH, 2013, EXP MOL MED, V45, DOI 10.1038/emm.2013.25 Liedtke W, 2000, CELL, V103, P525, DOI 10.1016/S0092-8674(00)00143-4 Mattson MP, AGING CELL Nilius B, 2013, EMBO REP, V14, P152, DOI 10.1038/embor.2012.219 Tabuchi K, 2005, NEUROSCI LETT, V382, P304, DOI 10.1016/j.neulet.2005.03.035 van der Vleuten AJW, 1998, EUR J HUM GENET, V6, P376, DOI 10.1038/sj.ejhg.5200229 Van Laer L, 2003, EAR HEARING, V24, P275, DOI 10.1097/01.AUD.0000079805.04016.03 Verma P, 2010, CHANNELS, V4, P319, DOI 10.4161/chan.4.4.12905 Wangemann P, 2006, J PHYSIOL-LONDON, V576, P11, DOI 10.1113/jphysiol.2006.112888 Zimon M, 2010, BRAIN, V133, P1798, DOI 10.1093/brain/awq109 NR 22 TC 0 Z9 0 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD DEC PY 2014 VL 123 IS 12 BP 859 EP 865 DI 10.1177/0003489414539130 PG 7 WC Otorhinolaryngology SC Otorhinolaryngology GA AU0KC UT WOS:000345310700008 PM 24963089 ER PT J AU Gaston, J Bartlett, RS Klemuk, SA Thibeault, SL AF Gaston, Joel Bartlett, Rebecca S. Klemuk, Sarah A. Thibeault, Susan L. TI Formulation and Characterization of a Porous, Elastomeric Biomaterial for Vocal Fold Tissue Engineering Research SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE cellular therapy; vocal folds; mechanomimetic; Tecoflex; elasticity; rheology; polyether polyurethane ID IN-VIVO BIOCOMPATIBILITY; EXTRACELLULAR-MATRIX; VASCULAR GRAFTS; POLYURETHANE; SCAFFOLDS; STIFFNESS; FREQUENCIES; BIOREACTOR; SUBSTRATE; CELLS AB Objective: Biomaterials able to mimic the mechanical properties of vocal fold tissue may be particularly useful for furnishing a 3-dimensional microenvironment allowing for in vitro investigation of cell and molecular responses to vibration. Motivated by the dearth of biomaterials available for use in an in vitro model for vocal fold tissue, we investigated polyether polyurethane (PEU) matrices, which are porous, mechanically tunable biomaterials that are inexpensive and require only standard laboratory equipment for fabrication. Methods: Rheology, dynamic mechanical analysis, and scanning electron microscopy were performed on PEU matrices at 5%, 10%, and 20% w/v mass concentrations. Results: For 5%, 10%, and 20% w/v concentrations, shear storage moduli were 2 kPa, 3.4 kPa, and 6 kPa, respectively, with shear loss moduli being 0.2 kPa, 0.38 kPa, and 0.62 kPa, respectively. Storage moduli responded to applied frequency as a linear function. Mercury intrusion porosimetry revealed that all 3 mass concentrations of PEU have a similar overall percentage porosity but differ in pore architecture. Conclusion: Twenty-pm diameter pores are ideal for cell seeding, and a range of mechanical properties indicates that the higher mass concentration PEU formulations are best suited for mimicking the viscoelastic properties of vocal fold tissue for in vitro research. C1 [Gaston, Joel; Thibeault, Susan L.] Univ Wisconsin, Dept Biomed Engn, Madison, WI 53792 USA. [Gaston, Joel; Bartlett, Rebecca S.; Thibeault, Susan L.] Univ Wisconsin, Dept Surg, Div Otolaryngol Head & Neck Surg, Madison, WI 53792 USA. [Klemuk, Sarah A.] Univ Iowa, Dept Commun Sci & Disorders, Iowa City, IA USA. RP Thibeault, SL (reprint author), Univ Wisconsin, Dept Surg, Div Otolaryngol Head & Neck Surg, Madison, WI 53792 USA. EM thibeaul@surgery.wisc.edu FU National Institute of Deafness and Other Communication Disorders [R01 DC009600]; David Bradley Fund; National Institutes of Health [R01 DC4336, T32 DC009401] FX The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: The authors acknowledge the National Institute of Deafness and Other Communication Disorders (R01 DC009600) and the David Bradley Fund for supporting this project. They also acknowledge the National Institutes of Health for funding this project (R01 DC4336 and T32 DC009401). CR Alberts B., 1994, MOL BIOL CELL, P971 Badylak SF, 2007, BIOMATERIALS, V28, P3587, DOI 10.1016/j.biomaterials.2007.04.043 Chan KMC, 2014, ACTA BIOMATER, V10, P2563, DOI 10.1016/j.actbio.2014.02.021 Chan RW, 2008, J ACOUST SOC AM, V124, P1207, DOI 10.1121/1.2946715 Discher DE, 2005, SCIENCE, V310, P1139, DOI 10.1126/science.1116995 Elbert DL, 1996, ANNU REV MATER SCI, V26, P365 Even-Ram S, 2006, CELL, V126, P645, DOI 10.1016/j.cell.2006.08.008 Gaston J, 2012, PLOS ONE, V7, DOI [10.1371/joumal.pone.0030965, DOI 10.1371/JOUMAL.PONE.0030965] Guan JJ, 2002, J BIOMED MATER RES, V61, P493, DOI 10.1002/jbm.10204 Hahn MS, 2006, ANN OTO RHINOL LARYN, V115, P225 Hahn MS, 2006, ANN OTO RHINOL LARYN, V115, P156 Han DK, 1997, MACROMOLECULES, V30, P6077, DOI 10.1021/ma970302u Karajanagi SS, 2011, ANN OTO RHINOL LARYN, V120, P175 Klemuk SA, 2004, LARYNGOSCOPE, V114, P1597, DOI 10.1097/00005537-200409000-00018 Laschke MW, 2009, ACTA BIOMATER, V5, P1991, DOI 10.1016/j.actbio.2009.02.006 Levental I, 2007, SOFT MATTER, V3, P299, DOI 10.1039/b610522j Mishkin GJ, 2007, CONTRIB NEPHROL, V154, P72 Mulder MM, 1998, J BIOMAT SCI-POLYM E, V9, P731, DOI 10.1163/156856298X00118 Nam YS, 1999, J BIOMED MATER RES, V47, P8, DOI 10.1002/(SICI)1097-4636(199910)47:1<8::AID-JBM2>3.0.CO;2-L Pelham RJ, 1997, P NATL ACAD SCI USA, V94, P13661, DOI 10.1073/pnas.94.25.13661 Riess G, 2003, PROG POLYM SCI, V28, P1107, DOI 10.1016/S0079-6700(03)00015-7 Rousseau B, 2003, LARYNGOSCOPE, V113, P620, DOI 10.1097/00005537-200304000-00007 SAKAS DE, 1990, J NEUROSURG, V73, P936, DOI 10.3171/jns.1990.73.6.0936 Shastri VP, 2000, P NATL ACAD SCI USA, V97, P1970, DOI 10.1073/pnas.97.5.1970 Sigal GB, 1998, J AM CHEM SOC, V120, P3464, DOI 10.1021/ja970819l Thibeault SL, 2002, J VOICE, V16, P96, DOI 10.1016/S0892-1997(02)00078-4 Thomas V, 2009, J BIOMED MATER RES A, V89A, P192, DOI 10.1002/jbm.a.31937 Titze IR, 2004, J BIOMECH, V37, P1521, DOI 10.1016/j.jbiomech.2004.01.007 Vance RJ, 2004, BIOMATERIALS, V25, P2095, DOI 10.1016/j.biomaterials.2003.08.064 Walluscheck KP, 1996, EUR J VASC ENDOVASC, V12, P321, DOI 10.1016/S1078-5884(96)80251-6 Wells RG, 2008, HEPATOLOGY, V47, P1394, DOI 10.1002/hep.22193 Williams RL, 2005, J MATER SCI-MATER M, V16, P1087, DOI 10.1007/s10856-005-4710-y Wolchok JC, 2009, BIOMATERIALS, V30, P327, DOI 10.1016/j.biomaterials.2008.08.035 Xue L, 2003, J VASC SURG, V37, P472, DOI 10.1067/mva.2003.88 NR 34 TC 0 Z9 0 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD DEC PY 2014 VL 123 IS 12 BP 866 EP 874 DI 10.1177/0003489414539131 PG 9 WC Otorhinolaryngology SC Otorhinolaryngology GA AU0KC UT WOS:000345310700009 PM 24944281 ER PT J AU Pollak, L Pollak, E AF Pollak, Lea Pollak, Eitan TI Headache During a Cluster of Benign Paroxysmal Positional Vertigo Attacks SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE BPPV; headache ID TENSION-TYPE HEADACHE; CERVICOGENIC HEADACHE; VESTIBULAR MIGRAINE; PROJECTIONS; DIAGNOSIS; NUCLEUS; NEURONS AB Objective: In view of patients' recurrent complaints, we were interested in investigating the frequency and headache characteristics in patients during a benign paroxysmal positional vertigo (BPPV) cluster. Methods: Patients with BPPV treated at an outpatient dizziness clinic were interviewed about the presence of headache; its quality, localization, severity, time course, and aggravating and alleviating factors; and headache-related disability during their present vertigo cluster. Results: Among 152 patients with BPPV, 53 (34.8%) reported headache associated with vertigo. According to The International Classification of Headache Disorders, 8(15%) patients could be classified as migraine without aura (1.1), 14 (26%) were classified as infrequent episodic tension-type headache associated with pericranial tenderness (2.1.1), 23 (43%) were classified as infrequent episodic tension-type headache without pericranial tenderness (2.1.2), 6 (11%) had cervicogenic headache (11.2.1), and in 2 (4%) patients, the headache could not be specified (14.2). Fifty-two age-matched BPPV patients without headache did not differ in history of headaches, BPPV history, or background diseases. The distribution of canal involvement and number of treatment maneuvers was also similar in both groups. Conclusion: Headache is frequent in BPPV. The most common is tension-type headache, followed by migraine and cervicogenic headache. Head pain seems to be an independently associated epiphenomenon of BPPV that can worsen patients' distress. C1 [Pollak, Lea] Tel Aviv Univ, Sackler Fac Med, Assaf Harofeh Med Ctr, Dept Neurol, IL-69978 Tel Aviv, Israel. [Pollak, Eitan] Haaretz Daily Newspaper, Tel Aviv, Israel. RP Pollak, L (reprint author), Kibutz Galuyot 4, Ness Ziona, Israel. EM lea.pollak@gmail.com CR Bernstein R, 2000, HEADACHES, P125 Bogduk N, 2009, LANCET NEUROL, V8, P959, DOI 10.1016/S1474-4422(09)70209-1 Boldingh MI, 2013, HEADACHE, V53, P1123, DOI 10.1111/head.12129 BOVIM G, 1992, PAIN, V51, P169, DOI 10.1016/0304-3959(92)90258-D Buisseret-Delmas C, 1999, J COM NEUROL, V409, P53 Cha YH, 2013, CEPHALALGIA, V33, P1160, DOI 10.1177/0333102413487999 Coskun O, 2003, CEPHALALGIA, V23, P842, DOI 10.1046/j.1468-2982.2003.00605.x Cui Y, 2013, J NEUROSCI RES, V91, P734 Dalkara T, 2006, NEUROL SCI, V27, pS86, DOI 10.1007/s10072-006-0577-z Eklund S, 1999, Auris Nasus Larynx, V26, P427, DOI 10.1016/S0385-8146(99)00022-X Furman JM, 2003, CURR OPIN NEUROL, V16, P5, DOI 10.1097/01.wco.0000053582.70044.e2 Halberstadt AL, 2006, NEUROSCIENCE, V140, P1067, DOI 10.1016/j.neuroscience.2006.02.053 Headache Classification Subcommittee of the International Headache Society, 2004, CEPHALALGIA S1, V24, P9, DOI DOI 10.1111/J.1468-2982.2003.00824.X Holroyd Kenneth A, 2002, Curr Pain Headache Rep, V6, P401, DOI 10.1007/s11916-002-0083-9 Lipchik GL, 1996, PAIN, V64, P467, DOI 10.1016/0304-3959(95)00174-3 Markia B, 2008, BRAIN STRUCT FUNCT, V213, P239, DOI 10.1007/s00429-008-0172-6 Metts BA, 2006, EXP BRAIN RES, V172, P261, DOI 10.1007/s00221-005-0328-z Olesen J, 2000, HEADACHES, P615 Parnes LS, 2003, CAN MED ASSOC J, V169, P681 Pollak L, 2003, OTOLARYNG HEAD NECK, V128, P829, DOI 10.1016/S0194-5998(03)00454-6 Radtke A, 2002, NEUROLOGY, V59, P1700 Radtke A, 2012, NEUROLOGY, V79, P1607, DOI 10.1212/WNL.0b013e31826e264f Smith PF, 2005, J VESTIBUL RES-EQUIL, V15, P1 Tfelt-Hansen PC, 2011, HEADACHE, V51, P752, DOI 10.1111/j.1526-4610.2011.01892.x Uneri Alev, 2004, Ear Nose Throat J, V83, P814 Vincent MB, 2010, CURR PAIN HEADACHE R, V14, P238, DOI 10.1007/s11916-010-0114-x von Brevern M, 2007, J NEUROL NEUROSUR PS, V78, P710, DOI 10.1136/jnnp.2006.100420 NR 27 TC 0 Z9 0 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD DEC PY 2014 VL 123 IS 12 BP 875 EP 880 DI 10.1177/0003489414539921 PG 6 WC Otorhinolaryngology SC Otorhinolaryngology GA AU0KC UT WOS:000345310700010 PM 25015924 ER PT J AU Ainsworth, TA Kobler, JB Loan, GJ Burns, JA AF Ainsworth, Tiffiny A. Kobler, James B. Loan, Gregory J. Burns, James A. TI Simulation Model for Transcervical Laryngeal Injection Providing Real-time Feedback SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE larynx; laryngology; otolaryngology; voice disorders; neurological disorders; motor speech disorders; vocal fold ID VALIDATION; EDUCATION; SURGERY AB Objective: This study aimed to develop and evaluate a model for teaching transcervical laryngeal injections. Methods: A 3-dimensional printer was used to create a laryngotracheal framework based on de-identified computed tomography images of a human larynx. The arytenoid cartilages and intrinsic laryngeal musculature were created in silicone from clay casts and thermoplastic molds. The thyroarytenoid (TA) muscle was created with electrically conductive silicone using metallic filaments embedded in silicone. Wires connected TA muscles to an electrical circuit incorporating a cell phone and speaker. A needle electrode completed the circuit when inserted in the TA during simulated injection, providing real-time feedback of successful needle placement by producing an audible sound. Face validation by the senior author confirmed appropriate tactile feedback and anatomical realism. Otolaryngologists pilot tested the model and completed presimulation and postsimulation questionnaires. Results: The high-fidelity simulation model provided tactile and audio feedback during needle placement, simulating transcervical vocal fold injections. Otolaryngology residents demonstrated higher comfort levels with transcervical thyroarytenoid injection on postsimulation questionnaires. Conclusion: This is the first study to describe a simulator for developing transcervical vocal fold injection skills. The model provides real-time tactile and auditory feedback that aids in skill acquisition. Otolaryngologists reported increased confidence with transcervical injection after using the simulator. C1 [Ainsworth, Tiffiny A.; Kobler, James B.; Burns, James A.] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Ctr Laryngeal Surg & Voice Rehabil,Dept Surg, Boston, MA 02114 USA. [Loan, Gregory J.] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Dept Radiol,Simulat Grp, Cambridge, MA 02138 USA. RP Burns, JA (reprint author), Harvard Univ, Sch Med, Massachusetts Gen Hosp, Ctr Laryngeal Surg & Voice Rehabil,Dept Surg, One Bowdoin Sq,11th Floor, Boston, MA 02114 USA. EM burns.james@mgh.harvard.edu FU Institute of Laryngology and Voice Restoration; "V" Foundation; Eugene B. Casey Foundation FX The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported in part by the Institute of Laryngology and Voice Restoration, the "V" Foundation, and the Eugene B. Casey Foundation. CR Accreditation Council for Graduate Medical Education, ACGME PROGR REQ GRAD Amin M, 2007, ANN OTO RHINOL LARYN, V116, P1 Blitzer A, 1998, LARYNGOSCOPE, V108, P1435, DOI 10.1097/00005537-199810000-00003 Broadhurst MS, 2007, ANN OTO RHINOL LARYN, V116, P917 Contag SR, 2009, LARYNGOSCOPE, V119, P211, DOI 10.1002/lary.20018 Fleming J, 2012, LARYNGOSCOPE, V122, P1099, DOI 10.1002/lary.23240 Javia L, 2012, OTOLARYNG HEAD NECK, V147, P999, DOI 10.1177/0194599812462007 Nixon IJ, 2012, LARYNGOSCOPE, V122, P140, DOI 10.1002/lary.22441 Verma SP, 2010, LARYNGOSCOPE, V120, P2241, DOI 10.1002/lary.21099 Zhang N, 2013, JAMA OTOLARYNGOL, V139, P1111, DOI 10.1001/jamaoto.2013.4720 NR 10 TC 0 Z9 0 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD DEC PY 2014 VL 123 IS 12 BP 881 EP 886 DI 10.1177/0003489414539922 PG 6 WC Otorhinolaryngology SC Otorhinolaryngology GA AU0KC UT WOS:000345310700011 PM 24963092 ER PT J AU Nemade, SV Naik, CS AF Nemade, Sanjana V. Naik, Chetana S. TI Treatment of Auricular Seroma: A Conservative, Innovative, and Effective Approach SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE auricular seroma; pseudocyst; aspiration; contour dressing; Plaster of Paris ID PSEUDOCYST; AURICLE; ASPIRATION; PRESSURE; PINNA AB Objective: Auricular seroma is a cystic swelling filled with serous fluid. It occurs spontaneously or following trauma. Successful treatment of the seroma remains a challenge because this disease has a high propensity for recurrence. The aim was to study the results of the Plaster of Paris (POP) cast in treatment of seroma in terms of complete resolution of swelling, recurrence, and auricular aesthesis. Study Design: Prospective. Setting: Smt. Kashibai Navale Medical College and General Hospital. Materials and Methods: A total of 48 patients with auricular seroma were studied. They were treated with aspiration of the cyst followed by compression dressing with a POP cast, taking the contour of the pinna. The POP cast was kept for 3 days. The patients were followed up for 6 months for recurrence. Results: Out of 48 patients, 43 patients had complete resolution of the swelling in a single application of the POP cast. Five patients needed 2 applications of the POP cast. Not a single patient had recurrence. Temporary discoloration or thickening of the pinna was noted in 8 patients. No major complications like perichondritis were noted. Conclusion: Aspiration and contour dressing using POP is an innovative and effective treatment for management of auricular seroma as it prevents surgical trauma and recurrence and gives cosmetically excellent results. C1 [Nemade, Sanjana V.; Naik, Chetana S.] Smt Kashibai Navale Med Coll & Gen Hosp, Pune 411041, Maharashtra, India. RP Nemade, SV (reprint author), Smt Kashibai Navale Med Coll & Gen Hosp, Off Sinhgad Rd, Pune 411041, Maharashtra, India. EM drsanjana31@yahoo.in CR CHOI S, 1984, ARCH OTOLARYNGOL, V110, P792 COHEN PR, 1990, ARCH OTOLARYNGOL, V116, P1202 Colditz Judy C, 2002, J Hand Ther, V15, P144, DOI 10.1053/hanthe.2002.v15.015014 Engel D, 1966, ARCH OTOLARYNGOL, V83, P29 Gunasekaran S, 2005, INTERNET J OTORHINOL, V4, P39 Hartmann A., 1846, ARCH OHREN NASEN KEH, V15, P156 Kanotra SP, 2009, AM J OTOLARYNG, V30, P73, DOI 10.1016/j.amjoto.2008.02.008 Kaur S, 2003, INDIAN J DERMATOL VE, V69, P85 Kunachak S, 1992, J OTOLARYNGOL, V21 Lim CM, 2002, LARYNGOSCOPE, V112, P2033, DOI 10.1097/00005537-200211000-00022 Naik SM, 2011, CLIN RHINOLOGY INT J, V4, P9 OPHIR D, 1991, PLAST RECONSTR SURG, V87, P783, DOI 10.1097/00006534-199104000-00030 Patigaroo SA, 2012, EUR ARCH OTO-RHINO-L, V269, P1747, DOI 10.1007/s00405-011-1805-6 Rehman A, 2013, INT J SCI RES PUBLIC, V3, P1 Salgado CJ, 2006, J PLAST RECONSTR AES, V59, P1450, DOI 10.1016/j.bjps.2006.01.029 Schulte KW, 2001, J AM ACAD DERMATOL, V44, P285, DOI 10.1067/mjd.2001.111616 NR 16 TC 0 Z9 0 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD NOV PY 2014 VL 123 IS 11 BP 749 EP + DI 10.1177/0003489414534014 PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA AR5QR UT WOS:000343639200001 PM 24847161 ER PT J AU Seren, E Ilhanli, I Muluk, NB Cingi, C Hanci, D AF Seren, Erdal Ilhanli, Ilker Muluk, Nuray Bayar Cingi, Cemal Hanci, Deniz TI Telephonic Analysis of the Snoring Sound Spectrum SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE transtelephonic analysis; snoring; sound spectrum; snoring sound intensity level; SSIL ID BODY-MASS INDEX; INTENSITY; APNEA; SLEEP AB Objective: Snoring is a sound caused by vibration of collapsed and/or unsteady airway walls of the pharynx and soft palate. We compared stored spectra of snoring sounds recorded via cell phone (CP) and a microphone placed over the head (head phone [HP]). Methods: Thirty-four snoring patients were included in this prospective study. Groups were identified by reference to body mass index (BMI) values: group I, BMI <25 kg/m(2) (n = 8); group 2, BMI 25 to 29 kg/m(2) (n = 10); and group 3, BMI >= 30 kg/m(2) (n = 16). Snoring sounds were recorded using CPs and HPs and digitally analyzed. We identified the frequencies with the highest snoring powers (F-max values) and snoring sound intensity levels (SSILs). Results: F-max ranged from 520 to 985 Hz in HP recordings and from 845 to 1645 Hz in CP recordings. Snoring sound intensity level values increased in proportion to BMI and were 6 to 24 dB in HP recordings and 19 to 52 dB in CP recordings. Thus, the CP values of F-max and SSIL were higher than the HP values. In obese patients of group 3, almost all F-max and SSIL values were higher than those of groups 1 and 2. In particular, the CP F-max values were elevated in such patients. The advanced technologies used in modern CPs may allow some snoring sounds in susceptible individuals to be defined as oronasal. Conclusion: Cell phone technology allows snoring to be evaluated in patients located in areas remote from a hospital. To explore the intensity of snoring and to postoperatively monitor the efficacy of surgery used to treat snoring, telephonic sound analysis is both new and effective and reduces the need for patient attendance at a hospital. Those experiencing severe snoring and/or who are obese should be told of what can be done to solve such problems. C1 [Seren, Erdal] Giresun Univ, ENT Dept, Giresun, Turkey. [Ilhanli, Ilker] Giresun Univ, Dept Phys Med & Rehabil, Giresun, Turkey. [Muluk, Nuray Bayar] Kirikkale Univ, ENT Dept, Kirikkale, Turkey. [Cingi, Cemal] Osmangazi Univ, ENT Dept, Eskisehir, Turkey. [Hanci, Deniz] Liv Hosp, ENT Dept, Istanbul, Turkey. RP Muluk, NB (reprint author), Birlik Mahallesi, Zirvekent 2 Etap Sitesi,C-3 Blok 62-43, TR-06610 Ankara, Turkey. EM nbayarmuluk@yahoo.com FU Continuous Education and Scientific Research Association FX The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: Except data collection, preparation of this article including designing and planning was supported by the Continuous Education and Scientific Research Association. CR 52nd World Medical Association General Assembly, 2000, JAMA-J AM MED ASSOC, V284, P3043 Bieger-Farhan AK, 2004, J LARYNGOL OTOL, V118, P135 Bielli Emilia, 2004, BMC Med Inform Decis Mak, V4, P7, DOI 10.1186/1472-6947-4-7 Cathcart RA, 2010, CLIN OTOLARYNGOL, V35, P198, DOI 10.1111/j.1749-4486.2010.02127.x Counter P, 2004, SLEEP MED REV, V8, P433, DOI 10.1016/j.smrv.2004.03.007 Fiz JA, 2010, LARYNGOSCOPE, V120, P854, DOI 10.1002/lary.20815 Gomez-Ambrosi J, 2012, INT J OBESITY, V36, P286, DOI 10.1038/ijo.2011.100 Lim Eugene Y, 2007, Conf Proc IEEE Eng Med Biol Soc, V2007, P6727 Nakano Hiroshi, 2008, J Clin Sleep Med, V4, P551 PEREZPADILLA JR, 1993, AM REV RESPIR DIS, V147, P635 Pevernagie D, 2010, SLEEP MED REV, V14, P131, DOI 10.1016/j.smrv.2009.06.002 Quinn CC, 2011, DIABETES CARE, V34, P1934, DOI 10.2337/dc11-0366 Seren E, 2005, AM J RHINOL, V19, P257 Seren E, 2014, INT J PEDIATR OTORHI, V78, P50, DOI 10.1016/j.ijporl.2013.10.017 Sovijarvi ARA, 2000, EUR RESPIR REV, V10, P591 Tang FH, 2004, J DIGIT IMAGING, V17, P217, DOI 10.1007/s10278-004-1015-5 TANGEL DJ, 1991, J APPL PHYSIOL, V70, P2574 WILSON K, 1985, LARYNGOSCOPE, V95, P1174 Wilson K, 1999, CHEST, V115, P762, DOI 10.1378/chest.115.3.762 NR 19 TC 0 Z9 0 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD NOV PY 2014 VL 123 IS 11 BP 758 EP 764 DI 10.1177/000348941453840 PG 7 WC Otorhinolaryngology SC Otorhinolaryngology GA AR5QR UT WOS:000343639200003 PM 24913290 ER PT J AU Young, N Abdelmessih, MW Sasaki, C AF Young, Nwanmegha Abdelmessih, Mikhail Wadie Sasaki, Clarence TI Hajek Revisited: A Histological Examination of the Quadrangular Membrane SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE Laryngeal neoplasm/physiology; laryngeal anatomy ID CANCER; SPREAD; BARRIERS; SURGERY AB Objective: The predictability of laryngeal cancer spread is due in part to connective tissue membranes. These membranes function as barriers to cancer and divide the larynx into subunits. The field of laryngeal conservation surgery is based on these concepts. The quadrangular membrane plays an important role, hindering the lateral spread of cancer in the larynx. The composition of this membrane has not been well described in the literature. In this study, we examine basic characteristics of the quadrangular membrane using histological techniques. Methods: Whole organ sections of the larynx were used. These sections were examined under a microscope with stains specific for collagen and elastin. Results: Examination of the sections revealed that the quadrangular membrane is made up of closely woven undulating collagen and elastic fibers. Conclusion: The quadrangular membrane is a fibroelastic structure providing a barrier to cancer spread. C1 [Young, Nwanmegha; Abdelmessih, Mikhail Wadie; Sasaki, Clarence] Yale Univ, Otolaryngol Sect, Dept Surg, New Haven, CT 06511 USA. [Abdelmessih, Mikhail Wadie] Cairo Univ, Otolaryngol Sect, Dept Surg, Giza, Egypt. RP Young, N (reprint author), Yale Univ, Otolaryngol Sect, Dept Surg, 800 Howard Ave, New Haven, CT 06511 USA. EM nwanmegha.young@yale.edu FU Virginia Wright Fund; Charles W. Ohse Endowment FX The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: Supported in part by the Virginia Wright Fund and the Charles W. Ohse Endowment. CR BLITZER A, 1979, B NEW YORK ACAD MED, V55, P813 BOCCA E, 1968, ANN OTO RHINOL LARYN, V77, P1005 Hajek M, 1891, ARCH KLIN CHIR, V42, P46 Jackel MC, 2007, EUR ARCH OTO-RHINO-L, V264, P577, DOI 10.1007/s00405-007-0280-6 KIRCHNER JA, 1987, ACTA OTO-LARYNGOL, V103, P503 KIRCHNER JA, 1974, CAN J OTOLARYNGOL, V3, P460 KIRCHNER JA, 1971, ANN OTO RHINOL LARYN, V80, P638 LEROUXRO.J, 1974, ANN OTO-LAR CHIR C-F, V91, P445 PRESSMAN J, 1956, Ann Otol Rhinol Laryngol, V65, P963 Rowe RG, 2009, ANNU REV CELL DEV BI, V25, P567, DOI 10.1146/annurev.cellbio.24.110707.175315 Som M L, 1970, J Laryngol Otol, V84, P655, DOI 10.1017/S0022215100072388 TUCKER G F Jr, 1962, Trans Am Acad Ophthalmol Otolaryngol, V66, P308 NR 12 TC 0 Z9 0 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD NOV PY 2014 VL 123 IS 11 BP 765 EP 768 DI 10.1177/0003489414538398 PG 4 WC Otorhinolaryngology SC Otorhinolaryngology GA AR5QR UT WOS:000343639200004 PM 24947408 ER PT J AU Chang, J Yung, KC AF Chang, Joseph Yung, Katherine C. TI Dysphonia and Vocal Fold Telangiectasia in Hereditary Hemorrhagic Telangiectasia SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE dysphonia; telangiectasia; vocal fold hemorrhage; hereditary hemorrhagic telangiectasia; HHT ID PULMONARY ARTERIOVENOUS-MALFORMATIONS AB Objective: This case report is the first documentation of dysphonia and vocal fold telangiectasia as a complication of hereditary hemorrhagic telangiectasia (HHT). Methods: Case report of a 40-year-old man with HHT presenting with 2 years of worsening hoarseness. Results: Hoarseness corresponded with a period of anticoagulation. Endoscopy revealed vocal fold scarring, vocal fold telangiectasias, and plica ventricularis suggestive of previous submucosal vocal fold hemorrhage and subsequent counterproductive compensation with ventricular phonation. Conclusion: Hereditary hemorrhagic telangiectasia may present as dysphonia with vocal fold telangiectasias and place patients at risk of vocal fold hemorrhage. C1 [Chang, Joseph] Univ Calif San Francisco, Sch Med, San Francisco, CA USA. [Yung, Katherine C.] Univ Calif San Francisco, Dept Otolaryngol, San Francisco, CA 94143 USA. RP Yung, KC (reprint author), UCSF Voice & Swallowing Ctr, 2330 Post St,5th Floor, San Francisco, CA 94115 USA. EM kyung@ohns.ucsf.edu CR AASSAR OS, 1991, LARYNGOSCOPE, V101, P977 FERENCE BA, 1994, CHEST, V106, P1387, DOI 10.1378/chest.106.5.1387 GUTTMACHER AE, 1994, AM J MED GENET, V52, P252, DOI 10.1002/ajmg.1320520232 PLAUCHU H, 1989, AM J MED GENET, V32, P291, DOI 10.1002/ajmg.1320320302 Shovlin CL, 2008, THORAX, V63, P259, DOI 10.1136/thx.2007.087452 NR 5 TC 0 Z9 0 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD NOV PY 2014 VL 123 IS 11 BP 769 EP 770 DI 10.1177/0003489414538400 PG 2 WC Otorhinolaryngology SC Otorhinolaryngology GA AR5QR UT WOS:000343639200005 PM 24913291 ER PT J AU Tatar, A Altas, E AF Tatar, Arzu Altas, Enver TI Effects of Radiofrequency Thermal Ablation on the Nasal Cycle Measured Using Rhinomanometry SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE nasal cycle; inferior concha hypertrophy; RFTA; anterior rhinomanometry; total nasal airflow; unilateral nasal airflow ID INFERIOR TURBINATE HYPERTROPHY; ACOUSTIC RHINOMETRY; AIR-FLOW; REDUCTION; CHILDREN; DISEASE; HEALTH AB Objective: This study was designed to research the effects of radiofrequency thermal ablation (RFTA) surgery on the nasal cycle, with anterior rhinomanometry being used for assessment. Methods: Thirty patients with inferior concha hypertrophy and 13 healthy volunteers were included in this study. An anterior rhinomanometry was performed on each of the patients before surgery and at 1 month and 6 months after surgery, and on the volunteers in the control group, simultaneously. Results: Nineteen of the 30 patients and 8 of the 13 healthy participants showed a distinct type of nasal cycle at different periods of measurement. The mean of the total nasal airflow of the patients was lower before RFTA surgery but increased at a rate of 71.07%, closer to the value of the control group, after RFTA surgery. After RFTA, the unilateral nasal airflow (fmin and fmax) values increased at ratios of 22.36% and 94.44%, respectively. The amplitude (fmax-fmin) showed a statistically significant decrease in the postoperative period (108.43 +/- 54.37), when compared with that of the preoperative period (202.80 +/- 81.24) (P < .01). Conclusion: We conclude that the RFTA is a useful method for treating inferior concha hypertrophy, because it positively affects the nasal physiology, increasing the total nasal airflow without changing the nasal cycle time. C1 [Tatar, Arzu] Reg Training & Res Hosp, Dept Otorhinolaryngol Head & Neck Surg, Erzurum, Turkey. [Altas, Enver] Ataturk Univ, Dept Otorhinolaryngol Head & Neck Surg, Fac Med, Erzurum, Turkey. RP Tatar, A (reprint author), Reg Training & Res Hosp, Dept Otorhinolaryngol Head & Neck Surg, Kulak Burun Bogaz Klin, Erzurum, Turkey. EM berke327@mynet.com CR Anselmo-Lima WT, 2001, AM J RHINOL, V15, P165, DOI 10.2500/105065801779954139 Beule AG, 2010, GMS CURR TOP OTORHIN, V9, DOI [10.3205/cto000071, DOI 10.3205/CTO000071] Brunworth J, 2013, AM J RHINOL ALLERGY, V27, P411, DOI 10.2500/ajra.2013.27.3912 Chin D, 2014, J LARYNGOL OTOL, V128, pS34, DOI 10.1017/S0022215113001631 Coste A, 2001, LARYNGOSCOPE, V111, P894, DOI 10.1097/00005537-200105000-00025 Eccles R, 1996, EUR RESPIR J, V9, P371, DOI 10.1183/09031936.96.09020371 Eccles R, 2000, ACTA OTO-LARYNGOL, V120, P580, DOI 10.1080/000164800750000388 FISHER EW, 1995, J LARYNGOL OTOL, V109, P503 Gallego AJ, 2006, AM J RHINOL, V20, P560, DOI 10.2500/ajr.2006.20.2951 Garzaro M, 2012, AM J RHINOL ALLERGY, V26, P321, DOI 10.2500/ajra.2012.26.3788 Gindros G, 2010, EUR ARCH OTO-RHINO-L, V267, P1727, DOI 10.1007/s00405-010-1260-9 Gungor A, 1999, OTOLARYNG HEAD NECK, V120, P238, DOI 10.1016/S0194-5998(99)70413-4 Hanif J, 2000, CLIN OTOLARYNGOL, V25, P461, DOI 10.1046/j.1365-2273.2000.00432.x Huang ZL, 2003, OTOLARYNG HEAD NECK, V128, P510, DOI 10.1016/mhn.2003.131 Hytonen ML, 2009, EUR ARCH OTO-RHINO-L, V266, P1257, DOI 10.1007/s00405-009-0914-y KERN E B, 1981, Rhinology (Utrecht), V19, P59 Kim JK, 2006, ACTA OTO-LARYNGOL, V126, P390, DOI 10.1080/00016480500401068 Ohki M, 2005, J OTOLARYNGOL, V34, P346, DOI 10.2310/7070.2005.34509 Passali D, 1999, ANN OTO RHINOL LARYN, V108, P569 Quine SM, 1999, ACTA OTO-LARYNGOL, V119, P911 Sargon M, 2009, EUR ARCH OTO-RHINO-L, V266, P231, DOI 10.1007/s00405-008-0722-9 Soane RJ, 2001, CLIN OTOLARYNGOL, V26, P9, DOI 10.1046/j.1365-2273.2001.00423.x Tahamiler R, 2009, ARCH OTOLARYNGOL, V135, P137, DOI 10.1001/archoto.2008.537 Willatt D, 2009, RHINOLOGY, V47, P227, DOI 10.4193/Rhin.09.017 Yepes-Nunez JJ, 2013, ALLERGOL IMMUNOPATH, V41, P397, DOI 10.1016/j.aller.2012.05.010 NR 25 TC 0 Z9 0 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD NOV PY 2014 VL 123 IS 11 BP 771 EP 777 DI 10.1177/0003489414538763 PG 7 WC Otorhinolaryngology SC Otorhinolaryngology GA AR5QR UT WOS:000343639200006 PM 24944272 ER PT J AU Heller, A Tanner, K Roy, N Nissen, SL Merrill, RM Miller, KL Houtz, DR Ellerston, J Kendall, K AF Heller, Amanda Tanner, Kristine Roy, Nelson Nissen, Shawn L. Merrill, Ray M. Miller, Karla L. Houtz, Daniel R. Ellerston, Julia Kendall, Katherine TI Voice, Speech, and Laryngeal Features of Primary Sjogren's Syndrome SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE primary Sjogren's syndrome (pSS); voice disorders; speech clarity; autoimmune disease ID QUALITY-OF-LIFE; DISEASE; INDEX; DYSPHONIA; JUDGMENTS; REGISTRY AB Objective: This study examined voice, speech, and laryngeal characteristics in primary Sjogren's syndrome (pSS). Methods: Eleven patients (10 female, 1 male; mean [SD] age = 57 [14] years) from The University of Utah Division of Rheumatology provided connected speech and sustained vowel samples. Analyses included the Multi-Dimensional Voice Profile, the Analysis of Dysphonia in Speech and Voice, and dysphonia severity, speech clarity, and videolaryngostroboscopy ratings. Results: Shimmer, amplitude perturbation quotient, and average fundamental frequency differed significantly from normative values (P < .01). Cepstral Spectral Index of Dysphonia values indicated mild-to-moderate dysphonia in connected speech (mean [SD] = 20.26 [8.36]) and sustained vowels (mean [SD] = 16.91 [11.08]). Ratings of dysphonia severity and speech clarity using 10-cm visual analog scales suggested mild-to-moderate dysphonia in connected speech (mean [SD] = 2.11 [1.72]) and sustained vowels (mean [SD] = 3.13 [2.20]) and mildly reduced speech clarity (mean [SD] = 1.46 [1.36]). Videolaryngostroboscopic ratings indicated mild-to-moderate dryness and mild reductions in overall laryngeal function. Voice Handicap Index scores indicated mild-to-moderate voice symptoms (mean [SD] = 43 [23]). Conclusion: Individuals with pSS may experience dysphonia and articulatory imprecision, typically in the mild-to-moderate range. These findings have implications for diagnostic and referral practices in pSS. C1 [Heller, Amanda; Roy, Nelson] Univ Utah, Dept Commun Sci & Disorders, Salt Lake City, UT USA. [Heller, Amanda; Tanner, Kristine; Roy, Nelson; Houtz, Daniel R.; Ellerston, Julia; Kendall, Katherine] Univ Utah, Voice Disorders Ctr, Salt Lake City, UT USA. [Tanner, Kristine; Nissen, Shawn L.] Brigham Young Univ, Dept Commun Disorders, Provo, UT 84602 USA. [Merrill, Ray M.] Brigham Young Univ, Dept Hlth Sci, Provo, UT 84602 USA. [Miller, Karla L.] Univ Utah, Sch Med, Div Rheumatol, Salt Lake City, UT USA. [Kendall, Katherine] Univ Utah, Sch Med, Div Otolaryngol Head & Neck Surg, Salt Lake City, UT USA. RP Tanner, K (reprint author), Brigham Young Univ, Dept Commun Disorders, 1190 N 900 E,158 TLRB, Provo, UT 84602 USA. EM kristine_tanner@byu.edu FU University of Utah Rehabilitation Services Clinical Research Grant; Brigham Young University McKay School of Education faculty planning grant FX The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by a University of Utah Rehabilitation Services Clinical Research Grant and a Brigham Young University McKay School of Education faculty planning grant. CR Awan SN, 2014, J VOICE, V28, P430, DOI 10.1016/j.jvoice.2013.12.008 Behrman A, 2008, J SPEECH LANG HEAR R, V51, P350, DOI 10.1044/1092-4388(2008/026) Belafsky Peter C, 2003, Curr Rheumatol Rep, V5, P297, DOI 10.1007/s11926-003-0008-6 Doig JA, 1971, BMJ-BRIT MED J, V20, P460 Eadie TL, 2010, J VOICE, V24, P564, DOI 10.1016/j.jvoice.2008.12.005 Eadie TL, 2007, ANN OTO RHINOL LARYN, V116, P695 Eisenberg LS, 1998, J SPEECH LANG HEAR R, V41, P327 Fairbanks G, 1960, VOICE ARTICULATION D Huang YF, 2013, CLIN DEV IMMUNOL, DOI 10.1155/2013/160491 Jacobson BH, 1997, AM J SPEECH-LANG PAT, V6, P66 Kruszka P, 2009, AM FAM PHYSICIAN, V79, P465 Lee M, 2005, CLIN OTOLARYNGOL, V30, P357, DOI 10.1111/j.1365-2273.2005.01022.x Lenderking WR, 2003, VALUE HEALTH, V6, P560, DOI 10.1046/j.1524-4733.2003.65243.x Malladi AS, 2012, ARTHRIT CARE RES, V64, P911, DOI 10.1002/acr.21610 Murano E, 2001, J VOICE, V15, P441, DOI 10.1016/S0892-1997(01)00044-3 Ogut F, 2005, AURIS NASUS LARYNX, V32, P375, DOI 10.1016/j.anl.2005.05.016 Palm O, 2013, RHEUMATOLOGY, V52, P173, DOI 10.1093/rheumatology/kes311 Peterson EA, 2013, J VOICE, V27, P401, DOI 10.1016/j.jvoice.2013.04.002 Reksten TR, 2014, ORAL MAXIL SURG CLIN, V26, P1, DOI 10.1016/j.coms.2013.09.002 Ruiz Allec LD, 2011, ACTA OTORRINOLARINGO, V62, P255 Sanz L, 2011, J VOICE, V26, P148 Seror R, 2012, J AUTOIMMUN, V39, P97, DOI 10.1016/j.jaut.2012.01.013 Shrivastav R, 2005, J SPEECH LANG HEAR R, V48, P323, DOI 10.1044/1092-4388(2005/022) NR 23 TC 1 Z9 1 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD NOV PY 2014 VL 123 IS 11 BP 778 EP 785 DI 10.1177/0003489414538762 PG 8 WC Otorhinolaryngology SC Otorhinolaryngology GA AR5QR UT WOS:000343639200007 PM 24944270 ER PT J AU Fritz, M Cerrati, E Fang, YX Verma, A Achlatis, S Lazarus, C Branski, RC Amin, M AF Fritz, Mark Cerrati, Eric Fang, Yixin Verma, Avanti Achlatis, Stratos Lazarus, Cathy Branski, Ryan C. Amin, Milan TI Magnetic Resonance Imaging of the Effortful Swallow SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE magnetic resonance imaging; effortful swallow; imaging; deglutition ID PHARYNGEAL PRESSURE; RISK-FACTORS; DYSPHAGIA; DEGLUTITION; PREVALENCE; ADULTS AB Objective: The effortful swallow was designed to improve posterior mobility of the tongue base and increase intraoral pressures. We characterized the effects of this maneuver via dynamic magnetic resonance imaging (dMRI) in healthy patients. Methods: A 3-T scanner was used to obtain dMRI images of patients swallowing pudding using normal as well as effortful swallows. Ninety sequential images were acquired at the level of the oropharynx in the axial plane for each swallow; 3 series were obtained for each swallow type for each patient. Images were acquired every 113 ms during swallowing. The images were analyzed with respect to oropharyngeal closure duration, anteroposterior and transverse distance between the oropharyngeal walls, and oropharyngeal area before and after closure. Results: Preswallow reduced pharyngeal area was observed (P = .02; mean = 212.61 mm(2) for effortful, mean = 261.92 mm(2) for normal) as well as prolonged pharyngeal closure during,the swallow (P < .0001; mean = 742.18 ms for effortful, mean = 437.31 ms for normal). No other differences were noted between swallow types. lnterrater and intrarater reliability of all measurements was excellent. Conclusion: This preliminary investigation is the first to evaluate the effects of effortful swallows via dMRI. In our cohort, consistent physiologic changes were elicited, consistent with clinical dogma regarding this maneuver. C1 [Fritz, Mark; Cerrati, Eric; Verma, Avanti; Achlatis, Stratos; Branski, Ryan C.; Amin, Milan] NYU, Sch Med, Dept Otolaryngol Head & Neck Surg, Voice Ctr, New York, NY 10016 USA. [Fang, Yixin] NYU, Sch Med, Div Biostat, Dept Populat Hlth, New York, NY 10016 USA. [Lazarus, Cathy] Albert Einstein Coll Med, Dept Otorhinolaryngol Head & Neck Surg, New York, NY USA. RP Branski, RC (reprint author), NYU, Sch Med, Dept Otolaryngol Head & Neck Surg, Voice Ctr, 345 East 37th St,Suite 306, New York, NY 10016 USA. EM ryan.branski@nyumc.org FU Clinical and Translational Science Institute at the New York University School of Medicine FX The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This research was supported, in part, by the Clinical and Translational Science Institute at the New York University School of Medicine. CR Amin MR, 2012, LARYNGOSCOPE, V122, P860, DOI 10.1002/lary.22496 Amin MR, 2013, ANN OTO RHINOL LARYN, V122, P145 Bulow M, 2001, DYSPHAGIA, V16, P190 Eslick GD, 2008, ALIMENT PHARM THERAP, V27, P971, DOI 10.1111/j.1365-2036.2008.03664.x Falsetti P, 2009, J STROKE CEREBROVASC, V18, P329, DOI 10.1016/j.jstrokecerebrovasdis.2009.01.009 Hind JA, 2001, ARCH PHYS MED REHAB, V82, P1661, DOI 10.1053/apmr.2001.28006 Hiss SG, 2005, DYSPHAGIA, V20, P149, DOI 10.1007/s00455-005-0008-y Huckabee ML, 2006, ARCH PHYS MED REHAB, V87, P1067, DOI 10.1016/j.apmr.2006.04.019 JOHNSSON F, 1995, AM J PHYSIOL-GASTR L, V269, pG653 Lafer M, 2013, ANN OTO RHINOL LARYN, V122, P748 Lazarus C, 2002, FOLIA PHONIATR LOGO, V54, P171, DOI 10.1159/000063192 Logemann JA, 1997, OTOLARYNG HEAD NECK, V116, P335, DOI 10.1016/S0194-5998(97)70269-9 Martin-Harris B, 2008, DYSPHAGIA, V23, P392, DOI 10.1007/s00455-008-9185-9 Roy N, 2007, ANN OTO RHINOL LARYN, V116, P858 Steele CM, 2007, DYSPHAGIA, V22, P30, DOI 10.1007/s00455-006-9037-4 Wilkins T, 2007, J AM BOARD FAM MED, V20, P144, DOI 10.3122/jabfm.2007.02.060045 NR 16 TC 0 Z9 0 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD NOV PY 2014 VL 123 IS 11 BP 786 EP 790 DI 10.1177/0003489414538607 PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA AR5QR UT WOS:000343639200008 PM 24916396 ER PT J AU Carpenter, TJ Kann, B Buckstein, MH Ko, EC Bakst, RL Misiukiewicz, KJ Posner, MR Genden, EM Gupta, V AF Carpenter, Todd J. Kann, Benjamin Buckstein, Michael H. Ko, Eric C. Bakst, Richard L. Misiukiewicz, Krzysztof J. Posner, Marshall R. Genden, Eric M. Gupta, Vishal TI Tolerability, Toxicity, and Temporal Implications of Transoral Robotic Surgery (TORS) on Adjuvant Radiation Therapy in Carcinoma of the Head and Neck SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE adjuvant radiation; head and neck cancer; intensity-modulated radiation therapy; transoral robotic surgery ID SQUAMOUS-CELL CARCINOMA; LOCALLY ADVANCED HEAD; POSTOPERATIVE IRRADIATION; OROPHARYNGEAL CARCINOMA; CANCER; CHEMOTHERAPY; EXPERIENCE; RADIOTHERAPY; TIME; TONGUE AB Objectives: Overall treatment package time (from surgery to radiotherapy [RT] completion) > 100 days can portend poor outcomes in head and neck cancer. Faster postoperative recovery seen with transoral robotic surgery may decrease treatment duration and toxicity for adjuvant RT and chemoradiation. Methods: We retrospectively reviewed all patients treated with transoral robotic surgery (n = 124) and adjuvant RT and chemoradiation (n = 33) at our institution for head and neck cancer from April 2007 to December 2011 to determine treatment duration, acute toxicity, and long-term percutaneous gastric tube rates. Results: The median overall treatment time was 86 days and from surgery to RT start was 41 days; median RT duration was 44 days. No wound breakdown or infection occurred during or after RT. Two-year actuarial locoregional control, distant metastasis free survival, and overall survival rates were 93%, 96%, and 97%, respectively. Conclusions: Adjuvant RT after transoral robotic surgery for head and neck cancer can be completed safely and in a timely fashion. Longer follow-up and a larger cohort will be needed to determine if this regimen is more effective than traditional surgery followed by adjuvant RT. C1 [Carpenter, Todd J.; Kann, Benjamin; Buckstein, Michael H.; Ko, Eric C.; Bakst, Richard L.; Gupta, Vishal] Mt Sinai Med Ctr, Dept Radiat Oncol, New York, NY 10029 USA. [Misiukiewicz, Krzysztof J.; Posner, Marshall R.] Mt Sinai Med Ctr, Dept Med, New York, NY 10029 USA. [Genden, Eric M.] Mt Sinai Med Ctr, Dept Otolaryngol Head & Neck Surg, New York, NY 10029 USA. RP Gupta, V (reprint author), Mt Sinai Med Ctr, Dept Radiat Oncol, 1184 Fifth Ave,1st Floor, New York, NY 10029 USA. EM vishal.gupta@mountsinai.org CR Ang KK, 2001, INT J RADIAT ONCOL, V51, P571, DOI 10.1016/S0360-3016(01)01690-X Bernier J, 2004, NEW ENGL J MED, V350, P1945, DOI 10.1056/NEJMoa032641 Bernier J, 2005, HEAD NECK-J SCI SPEC, V27, P843, DOI 10.1002/hed.20279 Boudreaux BA, 2009, ARCH OTOLARYNGOL, V135, P397, DOI 10.1001/archoto.2009.24 Cooper JS, 2004, NEW ENGL J MED, V350, P1937, DOI 10.1056/NEJMoa032646 de Arruda FF, 2006, INT J RADIAT ONCOL, V64, P363, DOI 10.1016/j.ijrobp.2005.03.006 Genden EM, 2009, HEAD NECK-J SCI SPEC, V31, P283, DOI 10.1002/hed.20972 HARRISON LB, 1994, INT J RADIAT ONCOL, V30, P953 Hinerman RW, 2004, HEAD NECK-J SCI SPEC, V26, P984, DOI 10.1002/hed.20091 Huang K, 2008, CANCER-AM CANCER SOC, V113, P497, DOI 10.1002/cncr.23578 Lawson JD, 2008, HEAD NECK-J SCI SPEC, V30, P327, DOI 10.1002/hed.20694 Lefebvre JL, 1996, J NATL CANCER I, V88, P890, DOI 10.1093/jnci/88.13.890 Moore EJ, 2012, MAYO CLIN PROC, V87, P219, DOI 10.1016/j.mayocp.2011.10.007 Parsons JT, 2002, CANCER, V94, P2967, DOI 10.1002/cncr.10567 Rosenthal DI, 2002, HEAD NECK-J SCI SPEC, V24, P115, DOI 10.1002/hed.10038 Rusthoven KE, 2008, LARYNGOSCOPE, V118, P635, DOI 10.1097/MLG.0b013e31815fdf0e Sher DJ, 2011, INT J RADIAT ONCOL, V81, pE813, DOI 10.1016/j.ijrobp.2010.12.005 Suwinski R, 2003, INT J RADIAT ONCOL, V56, P399, DOI 10.1016/S0360-3016-(02)04469-3 WOLF GT, 1991, NEW ENGL J MED, V324, P1685 Weinstein GS, 2012, LARYNGOSCOPE, V122, P1701, DOI 10.1002/lary.23294 NR 20 TC 0 Z9 0 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD NOV PY 2014 VL 123 IS 11 BP 791 EP 797 DI 10.1177/0003489414535560 PG 7 WC Otorhinolaryngology SC Otorhinolaryngology GA AR5QR UT WOS:000343639200009 PM 24847162 ER PT J AU Piazza, C Del Bon, F Paderno, A Grazioli, P Mangili, S Lombardi, D Nicolai, P Peretti, G AF Piazza, Cesare Del Bon, Francesca Paderno, Alberto Grazioli, Paola Mangili, Stefano Lombardi, Davide Nicolai, Piero Peretti, Giorgio TI Complications After Tracheal and Cricotracheal Resection and Anastomosis for Inflammatory and Neoplastic Stenoses SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE complications; tracheal resection; cricotracheal resection; anastomosis; neoplastic stenoses; inflammatory stenoses ID LARYNGOTRACHEAL STENOSIS; SUBGLOTTIC STENOSIS; RECONSTRUCTION; MANAGEMENT; PRESERVATION; EXPERIENCE; SURGERY; REPAIR; NECK AB Objective: This study aimed to evaluate complications and success rates of tracheal resection and anastomosis (TRA) and cricotracheal resection and anastomosis (CTRA) in patients treated in 2 academic institutions. Methods: Retrospective charts review of 137 patients submitted to TRA/CTRA. Fifty (36.5%) had neoplastic (group A) and 87 (63.5%) benign (group B) stenoses. Using univariate analysis, age, medical comorbidities, previous radiotherapy, type of TRA/CTRA, association with neck dissection and thyroidectomy, length of resected airway, and preoperative tracheotomy were evaluated to identify factors predictive of complications and outcomes. Results: The mean length of resected airway was 2.7 and 3 cm in groups A and B, respectively. Overall decannulation and complication rates for group A were 96% and 36%, and 99% and 46% for group B, respectively. Length of airway resected and presence of preoperative tracheotomy had a statistically significant effect on major surgical complications. Age older than 70 and cardiovascular and pulmonary comorbidities were significantly associated with the incidence of major medical complications. No statistically significant difference was found considering the complication rates of group A versus group B. Conclusion: Even though the overall success rate of TRA/CTRA is high, it should always be regarded as a major surgical procedure with a non-negligible incidence of complications. C1 [Piazza, Cesare; Del Bon, Francesca; Paderno, Alberto; Grazioli, Paola; Mangili, Stefano; Lombardi, Davide; Nicolai, Piero] Univ Brescia, Dept Otorhinolaryngol Head & Neck Surg, I-25123 Brescia, Italy. [Peretti, Giorgio] Univ Genoa, Dept Otorhinolaryngol Head & Neck Surg, Genoa, Italy. RP Piazza, C (reprint author), Univ Brescia, Spedali Civili Brescia, Dept Otorhinolaryngol Head & Neck Surg, Piazza Spedali Civili 1, I-25123 Brescia, Italy. EM ceceplaza@libero.it CR Abbasidezfouli Azizollah, 2009, Interact Cardiovasc Thorac Surg, V9, P446, DOI 10.1510/icvts.2009.202978 Amorós Juan Moya, 2006, Eur J Cardiothorac Surg, V29, P35, DOI 10.1016/j.ejcts.2005.10.023 Ashiku SK, 2004, J THORAC CARDIOV SUR, V127, P99, DOI 10.1016/j.jtcvs.2002.11.001 Ch'ng S, 2012, J PLAST RECONSTR AES, V65, P1645, DOI 10.1016/j.bjps.2012.07.008 Ciccone AM, 2004, EUR J CARDIO-THORAC, V26, P818, DOI 10.1016/j.ejcts.2004.06.020 Donahue DM, 1997, J THORAC CARDIOV SUR, V114, P934, DOI 10.1016/S0022-5223(97)70007-2 Gaissert HA, 2007, ANN THORAC SURG, V83, P1952, DOI 10.1016/j.athoracsur.2007.01.056 George M, 2005, EUR ARCH OTO-RHINO-L, V262, P609, DOI 10.1007/s00405-004-0887-9 GERWAT J, 1974, LARYNGOSCOPE, V84, P940, DOI 10.1288/00005537-197406000-00008 Giudice M, 2003, EUR ARCH OTO-RHINO-L, V260, P235, DOI 10.1007/s00405-002-0554-y GRILLO HC, 1992, ANN THORAC SURG, V53, P54 GRILLO HC, 1986, J THORAC CARDIOV SUR, V91, P322 GRILLO HC, 1964, J THORAC CARDIOV SUR, V48, P741 Jovic RM, 2012, EUR ARCH OTO-RHINO-L, V269, P1805, DOI 10.1007/s00405-012-1940-8 Krajc Tibor, 2009, Interact Cardiovasc Thorac Surg, V9, P983, DOI 10.1510/icvts.2009.213215 Laccourreye O, 1997, ARCH OTOLARYNGOL, V123, P1074 Lano CF, 1998, ANN OTO RHINOL LARYN, V107, P92 Macchiarini P, 2001, J THORAC CARDIOV SUR, V121, P68, DOI 10.1067/mtc.2001.111420 Marulli Giuseppe, 2008, Interact Cardiovasc Thorac Surg, V7, P227, DOI 10.1510/icvts.2007.168054 Mutrie CJ, 2011, ANN THORAC SURG, V91, P1101, DOI 10.1016/j.athoracsur.2010.11.066 MYER CM, 1994, ANN OTO RHINOL LARYN, V103, P319 Negm H, 2013, EUR ARCH OTO-RHINO-L, V270, P2709, DOI 10.1007/s00405-013-2367-6 PEARSON FG, 1975, J THORAC CARDIOV SUR, V70, P806 Pena J, 2001, OTOLARYNG HEAD NECK, V125, P397, DOI 10.1067/mhn.2001.117372 PESKIND SP, 1993, LARYNGOSCOPE, V103, P203 Piazza C, 2014, LARYNGOSCOPE, V124, P907, DOI 10.1002/lary.24416 Primov-Fever A, 2006, ISRAEL MED ASSOC J, V8, P543 Rea F, 2002, EUR J CARDIO-THORAC, V22, P352, DOI 10.1016/S1010-7940(02)00342-1 Wolf M, 2001, LARYNGOSCOPE, V111, P622, DOI 10.1097/00005537-200104000-00012 Wright CD, 2004, J THORAC CARDIOV SUR, V128, P731, DOI 10.1016/j.jtcvs.2004.07.005 NR 30 TC 0 Z9 0 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD NOV PY 2014 VL 123 IS 11 BP 798 EP 804 DI 10.1177/0003489414538764 PG 7 WC Otorhinolaryngology SC Otorhinolaryngology GA AR5QR UT WOS:000343639200010 PM 24944273 ER PT J AU Liu, SC Chou, YF Su, WF AF Liu, Shao-Cheng Chou, Yi-Fan Su, Wan-Fu TI A Rapid and Accurate Technique for the Identification of the Recurrent Laryngeal Nerve SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE recurrent laryngeal nerve; approach; thyroid surgery; trachea ID INFERIOR THYROID ARTERY; ZUCKERKANDL TUBERCLE; SURGERY; PARALYSIS; LIGAMENT; BERRY; RISK AB Objective: We studied the anatomic relationship between the recurrent laryngeal nerve (RLN) and the third tracheal ring, which was very important for rapid identification of RLN in our hands. Methods: This study was initially performed using 8 fresh cadavers (4 female and 4 male). The transverse nerve location from the third trachea and the depth from its anterior surface were measured. We further observed the topography of RLN in relation to the trachea in 60 patients, between November 2008 and January 2011, at the Tr-Service General Hospital and Buddhist Tzu Chi General Hospital, Taipei Branch, Taiwan, with 46 lobo-isthmectomies and 14 total thyroidectomies. The time spent in identifying the RLN was also recorded. Results: Among cadaver groups, the transverse distance (width) and the vertical distance (depth) averaged 3.3 and 17.6 mm, respectively. Among the clinical cases, the width and depth averaged 4.4 and 14.6 mm, respectively. The depth measured in males was significantly deeper than that in females (22.3 vs 13.2 mm) (P < .05). The time spent in identifying the RLN after starting dissection in the RLN triangle was not statistically significantly different between the cadaver group and the clinical group (10.6 +/- 5.7 seconds and 15.5 +/- 17.7 seconds, respectively; P> .05). The median time was 9 and 10 seconds, respectively. There was no statistically significant side-to-side difference in terms of the time spent in searching for the RLN. Conclusion: Using the third ring as guidance, our inferior-superior technique offers an extra benefit in identifying the RLN safely and quickly, as compared to the conventional inferior approach. C1 [Liu, Shao-Cheng] Triserv Gen Hosp, Dept Otolaryngol Head & Neck Surg, Natl Def Med Ctr, Taipei, Taiwan. [Chou, Yi-Fan; Su, Wan-Fu] Buddhist Tzu Chi Gen Hosp, Dept Otolaryngol Head & Neck Surg, Taipei Branch, New Taipei City 23142, Taiwan. [Chou, Yi-Fan] Taichung Tzu Chi Hosp, Dept Otolaryngol Head & Neck Surg, Buddhist Tzu Chi Med Fdn, Taichung, Taiwan. [Su, Wan-Fu] Tzu Chi Univ, Dept Otolaryngol Head & Neck Surg, Sch Med, Hualien, Taiwan. RP Su, WF (reprint author), Buddhist Tzu Chi Gen Hosp, Dept Otolaryngol Head & Neck Surg, Taipei Branch, 289 Jianguo Rd, New Taipei City 23142, Taiwan. EM wfs19582001@yahoo.com.tw CR Delbridge L, 2003, ANZ J SURG, V73, P761, DOI 10.1046/j.1445-2197.2003.02756.x Eckel HE, 2003, ANN OTO RHINOL LARYN, V112, P103 Elsheikh E, 2012, LARYNGOSCOPE, V122, P2355, DOI 10.1002/lary.23419 Gravante G, 2007, AM J SURG, V193, P484, DOI 10.1016/j.amjsurg.2006.06.040 Haller JM, 2012, SPINE, V37, P97, DOI 10.1097/BRS.0b013e31821f3e86 Hepgul G, 2013, J THYROID RES, P2013 Hermann M, 2002, ANN SURG, V235, P261, DOI 10.1097/00000658-200202000-00015 Higgins TS, 2011, LARYNGOSCOPE, V121, P1009, DOI 10.1002/lary.21578 Ishimoto S, 2003, LARYNGOSCOPE, V113, P1088, DOI 10.1097/00005537-200306000-00034 John A, 2012, AM SURGEON, V78, P947 Kaisha W, 2011, CLIN ANAT, V24, P853, DOI 10.1002/ca.21192 Kandil E, 2011, SURGERY, V150, P1222, DOI 10.1016/j.surg.2011.09.002 Kulekci M, 2012, ANN OTO RHINOL LARYN, V121, P650 Miyauchi A, 2013, SURG TODAY, V43, P225, DOI 10.1007/s00595-012-0236-3 Mohil RS, 2011, ANN ROY COLL SURG, V93, P49, DOI 10.1308/003588410X12771863936927 O'Neill JP, 2008, SURG-J R COLL SURG E, V6, P373 Randolph GW, 2004, WORLD J SURG, V28, P755, DOI 10.1007/s00268-004-7348-x Serpell JW, 2010, ANN SURG ONCOL, V17, P1628, DOI 10.1245/s10434-010-0928-0 Tang WJ, 2012, SURG RADIOL ANAT, V34, P325, DOI 10.1007/s00276-011-0905-8 Thomusch O, 2000, WORLD J SURG, V24, P1335 Veyseller B, 2011, ARCH OTOLARYNGOL, V137, P897, DOI 10.1001/archoto.2011.134 Yalcin B, 2006, SURGERY, V139, P181, DOI 10.1016/j.surg.2005.06.035 NR 22 TC 0 Z9 0 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD NOV PY 2014 VL 123 IS 11 BP 805 EP 810 DI 10.1177/0003489414538765d PG 6 WC Otorhinolaryngology SC Otorhinolaryngology GA AR5QR UT WOS:000343639200011 PM 24944276 ER PT J AU Takeshita-Monaretti, TK Dantas, RO Ricz, H Aguiar-Ricz, LN AF Takeshita-Monaretti, Telma Kioko Dantas, Roberto Oliveira Ricz, Hilton Aguiar-Ricz, Lilian Neto TI Correlation of Maximum Phonation Time and Vocal Intensity With Intraluminal Esophageal and Pharyngoesophageal Pressure in Total Laryngectomees SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE alaryngeal speech; manometry; tracheoesophageal prosthesis; total laryngectomy ID TRACHEOESOPHAGEAL VOICE; SPEECH; SEGMENT; MOTILITY; SPEAKERS; TOOL AB Objective: This study aimed to correlate maximum phonation time, vocal intensity, and dynamic extension with intraluminal esophageal and pharyngoesophageal segment pressure during tracheoesophageal phonation. Design: Prospective analysis. Setting: Tertiary academic hospital. Methods: The study was conducted on 20 total laryngectomees with alaryngeal speech and with secondary insertion of a tracheoesophageal prosthesis who were submitted to vocal recording of maximum phonation time and vocal intensity (minimum, habitual, and maximum). The participants were then submitted to manometry for the determination of the amplitude of intraluminal esophageal (proximal, middle, and distal) and pharyngoesophageal segment pressure during phonation. Results: A significant positive correlation was detected between habitual vocal intensity and the middle (0.004) and distal (0.05) esophagus, in addition to a correlation of maximum intensity with the middle esophageal portion (0.03). Dynamic extension showed correlation with the amplitude of esophageal pressure. There was no significant correlation between the variables studied and pressure of the pharyngoesophageal segment or between maximum phonation time and esophageal pressure amplitude. Conclusion: The middle and distal regions of the esophagus were found to be compliant, permitting an adjustment of vocal intensity. There was no correlation between maximum phonation time and the amplitude of esophageal and pharyngoesophageal segment pressure. C1 [Takeshita-Monaretti, Telma Kioko; Ricz, Hilton; Aguiar-Ricz, Lilian Neto] Univ Sao Paulo, Dept Ophthalmol Otorhinolaryngol & Head & Neck Su, Fac Med Ribeirao Preto, BR-14048900 Ribeirao Preto, SP, Brazil. [Dantas, Roberto Oliveira] Univ Sao Paulo, Dept Internal Med, Fac Med Ribeirao Preto, BR-14048900 Ribeirao Preto, SP, Brazil. RP Ricz, H (reprint author), Univ Sao Paulo, Dept Ophthalmol Otorhinolaryngol & Head & Neck Su, Fac Med Ribeirao Preto, Av Bandeirantes 3900, BR-14048900 Ribeirao Preto, SP, Brazil. EM hricz@fmrp.usp.br FU Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES); Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [2008/07793-8] FX The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: Research supported by Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES) and Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP Protocol No. 2008/07793-8). CR Aguiar-Ricz L, 2010, ANN OTO RHINOL LARYN, V119, P729 Aguiar-Ricz L, 2007, J VOICE, V21, P248, DOI 10.1016/j.jvoice.2005.11.001 Allan W, 2009, J LARYNGOL OTOL, V123, P666, DOI 10.1017/S002221510800371X Bunting GW, 2004, OTOLARYNG CLIN N AM, V37, P597, DOI 10.1016/j.otc.2004.01.007 Ceccon FP, 1998, REV BRAS CIR CABECA, V22, P21 Chone Carlos T, 2009, Braz J Otorhinolaryngol, V75, P182 Dantas RO, 2002, DYSPHAGIA, V17, P121, DOI 10.1007/s00455-001-0111-7 Dantas RO, 2005, DYSPHAGIA, V20, P101, DOI 10.1007/s00455-004-0027-0 Dantas Roberto Oliveira, 2001, Arquivos de Gastroenterologia, V38, P158, DOI 10.1590/S0004-28032001000300003 Deschler DG, 1999, OTOLARYNG HEAD NECK, V121, P23, DOI 10.1016/S0194-5998(99)70117-8 DURANCEAU A, 1976, AM J SURG, V131, P30, DOI 10.1016/0002-9610(76)90416-5 Grolman W, 2007, ORL J OTO-RHINO-LARY, V69, P68, DOI 10.1159/000097401 Grolman W, 2008, AURIS NASUS LARYNX, V35, P83, DOI 10.1016/j.anl.2007.08.003 Kazi R, 2009, J VOICE, V23, P247, DOI 10.1016/j.jvoice.2007.01.006 Kazi R, 2006, CLIN OTOLARYNGOL, V31, P518, DOI 10.1111/j.1365-2273.2006.01320.x Kotby MN, 2009, FOLIA PHONIATR LOGO, V61, P24, DOI 10.1159/000188660 Lundstrom E, 2008, LOGOP PHONIATR VOCO, V33, P115, DOI 10.1080/14015430701855788 MORGAN DW, 1992, J LARYNGOL OTOL, V106, P353, DOI 10.1017/S0022215100119474 Most T, 2000, J COMMUN DISORD, V33, P165, DOI 10.1016/S0021-9924(99)00030-1 Motta S, 2001, ARCH OTOLARYNGOL, V127, P700 Reisi N, 2013, ACTA CIR BRAS, V28, P391, DOI 10.1590/S0102-86502013000500012 Takeshita Telma Kioko, 2010, Pro Fono, V22, P485, DOI 10.1590/S0104-56872010000400021 Takeshita TK, 2013, HEAD NECK-J SCI SPEC, V35, P500, DOI 10.1002/hed.22921 van As CJ, 2001, ARCH OTOLARYNGOL, V127, P161 van Weissenbruch R, 2000, ANN OTO RHINOL LARYN, V109, P311 NR 25 TC 0 Z9 0 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD NOV PY 2014 VL 123 IS 11 BP 811 EP 816 DI 10.1177/0003489414538766 PG 6 WC Otorhinolaryngology SC Otorhinolaryngology GA AR5QR UT WOS:000343639200012 PM 24944280 ER PT J AU Gooi, Z Ishman, SL Bock, JM Blumin, JH Akst, LM AF Gooi, Zhen Ishman, Stacey L. Bock, Jonathan M. Blumin, Joel H. Akst, Lee M. TI Laryngopharyngeal Reflux: Paradigms for Evaluation, Diagnosis, and Treatment SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE laryngopharyngeal reflux; symptoms and signs; treatment; diagnosis ID POSITION STATEMENT AB Objective: This study aimed to describe current patterns for diagnosis and treatment of laryngopharyngeal reflux (LPR) and analyze differences between laryngologists and non-laryngologists. Methods: American Academy of Otolaryngology Head and Neck Surgery and American Broncho-Esophagological Association members were invited to complete an online survey regarding evaluation, diagnosis, and treatment of LPR. Subgroup analysis was performed to identify differences between respondents who completed laryngology fellowships (LF) and those who did not (NL). Results: Of 159 respondents, 40 were LF. Video documentation of laryngopharyngeal exams was almost universal among LF (97% vs 38%, P < .0001). Use of rigid (100%, P = .002) and flexible distal-chip technologies (94%, P = .004) was more common among LF. Diagnostic criteria were similar between the groups, with symptoms of heartburn, globus, and throat clearing thought most suggestive of LPR. Adjunctive tests most commonly used were barium esophagram and dual-probe pH testing with impedance. Laryngology fellowship-trained respondents used dual pH probes with impedance more often (P = .004). They were more likely to prescribe twice daily proton pump inhibitors with concurrent H2-blocker medication initially (P = .004) and to treat for longer than 4 weeks (P = .0003). Conclusion: Otolaryngologists are in agreement on symptoms and physical features of LPR; however, significant differences exist between laryngologists and non-laryngologists on the use of adjunctive testing and treatment strategies. C1 [Gooi, Zhen; Akst, Lee M.] Johns Hopkins Univ, Dept Otolaryngol Head & Neck Surg, Baltimore, MD USA. [Ishman, Stacey L.] Cincinnati Childrens Med Ctr, Dept Otolaryngol Head & Neck Surg, Cincinnati, OH USA. [Bock, Jonathan M.; Blumin, Joel H.] Med Coll Wisconsin, Dept Otolaryngol & Commun Sci, Milwaukee, WI 53226 USA. RP Akst, LM (reprint author), Johns Hopkins Outpatient Ctr, Dept Otolaryngol Head & Neck Surg, 601 N Caroline St, Baltimore, MD 21287 USA. EM lakst1@jhmi.edu CR Altman KW, 2011, LARYNGOSCOPE, V121, P717, DOI 10.1002/lary.21429 Amin MR, 2008, OTOLARYNG HEAD NECK, V138, P411, DOI 10.1016/j.otohns.2007.12.032 Belfasky PC, 2002, J VOICE, V16, P274 Belfasky PC, 2001, LARYNGOSCOPE, V111, P1313 Book DT, 2002, LARYNGOSCOPE, V112, P1399, DOI 10.1097/00005537-200208000-00014 Eller R, 2009, J VOICE, V23, P389, DOI 10.1016/j.jvoice.2007.10.007 Harrell SP, 2007, LARYNGOSCOPE, V117, P470, DOI 10.1097/MLG.0b013e31802d344c Kahrilas Peter J, 2008, Gastroenterology, V135, P1383, DOI 10.1053/j.gastro.2008.08.045 Koufman JA, 2002, OTOLARYNG HEAD NECK, V127, P32, DOI 10.1067/mhn.2002.125760 Milstein CF, 2005, LARYNGOSCOPE, V115, P2256, DOI 10.1097/01.mlg.0000184325.44968.b1 Schwartz SR, 2009, OTOLARYNG HEAD NECK, V141, pS1, DOI 10.1016/j.otohns.2009.06.744 Vavricka SR, 2007, AM J GASTROENTEROL, V102, P716, DOI 10.1111/j.1572-0241.2007.01145.x YANAGISAWA E, 1993, ANN OTO RHINOL LARYN, V102, P255 NR 13 TC 0 Z9 0 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD OCT PY 2014 VL 123 IS 10 BP 677 EP + DI 10.1177/0003489414532777 PG 9 WC Otorhinolaryngology SC Otorhinolaryngology GA AP7MQ UT WOS:000342261800001 PM 24789800 ER PT J AU Yetiser, S Ince, D Gul, M AF Yetiser, Sertac Ince, Dilay Gul, Murat TI An Analysis of Vestibular Evoked Myogenic Potentials in Patients With Benign Paroxysmal Positional Vertigo SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE vestibular evoked myogenic potential; benign paroxysmal positional vertigo ID AGE-RELATED-CHANGES; TEST-RETEST RELIABILITY; MENIERES-DISEASE; DIAGNOSTIC-VALUE AB Objective: Vestibular evoked myogenic potentials (VEMPs) selectively test the vestibular end-organ. The aim of this study was to analyze how the site of the diseased canal, type of particulate deposition, duration of symptoms, severity of nystagmus, recurrence, and age affect the VEMP in patients with benign paroxysmal positional vertigo (BPPV). Methods: One hundred two patients were enrolled in the study between 2009 and 2012. There were 36 men and 66 women with ages ranging from 16 to 71 years (mean age, 42.28 +/- 11.29 years). Patients with BPPV were tested with roll-on and head-hanging maneuvers under video-electronystagmography monitoring and with air conduction cervical VEMP testing. Patients were grouped for duration, severity, recurrence, age, site of canal involvement, and so on, and the results were compared in each subgroup. Kruskal Wallis and Mann Whitney U tests were used for the comparative analysis. Results: Twenty-four patients (23.5%) had a gross VEMP abnormality (absence of VEMP in 6 and greater than 25% depression of the amplitude in 18). Abnormality of VEMPs was not correlated with factors including age, severity of nystagmus, number of maneuvers applied, and the site of canal involvement (P < .05). However, persistence or recurrence of symptoms has an effect on VEMP results (P = .016). Conclusion: Vestibular evoked myogenic potential is a useful tool to study the otolithic function in patients with BPPV and should be included in the test battery. C1 [Yetiser, Sertac; Ince, Dilay] Anadolu Med Ctr, Dept Otorhinolaryngol Head & Neck Surg, TR-41400 Gebze, Kocaeli, Turkey. [Gul, Murat] Univ Giresun, Dept Stat, Giresun, Turkey. RP Yetiser, S (reprint author), Anadolu Med Ctr, Dept Otorhinolaryngol Head & Neck Surg, Cumhuriyet Mah,2255 Sok,3, TR-41400 Gebze, Kocaeli, Turkey. EM syetiser@yahoo.com CR Agrawal Y, 2012, OTOL NEUROTOL, V33, P832, DOI 10.1097/MAO.0b013e3182545061 Akkuzu G, 2006, EUR ARCH OTO-RHINO-L, V263, P510, DOI 10.1007/s00405-005-0002-x Basta D, 2007, J VESTIBUL RES-EQUIL, V17, P93 Basta D, 2005, CLIN NEUROPHYSIOL, V116, P2216, DOI 10.1016/j.clinph.2005.06.010 Bush ML, 2010, ENT-EAR NOSE THROAT, V89, P170 Chang CH, 2007, INT J PEDIATR OTORHI, V71, P495, DOI 10.1016/j.ijporl.2006.12.001 COLEBATCH JG, 1992, NEUROLOGY, V42, P1635 COLEBATCH JG, 1994, J NEUROL NEUROSUR PS, V57, P190, DOI 10.1136/jnnp.57.2.190 Colebatch JG, 2009, EXP BRAIN RES, V199, P167, DOI 10.1007/s00221-009-1993-0 Di Girolamo S, 2000, EUR ARCH OTO-RHINO-L, V257, P372, DOI 10.1007/s004050000243 Eryaman E, 2012, B-ENT, V8, P247 Gacek RR, 2003, ANN OTO RHINOL LARYN, V112, P574 Hong SM, 2008, ACTA OTO-LARYNGOL, V128, P861, DOI 10.1080/00016480701784981 Hong SM, 2008, AM J OTOLARYNG, V29, P184, DOI 10.1016/j.amjoto.2007.07.004 Isaradisaikul S, 2008, OTOL NEUROTOL, V29, P542, DOI 10.1097/MAO.0b013e31816c7c25 Lee JD, 2013, ACTA OTO-LARYNGOL, V133, P150, DOI 10.3109/00016489.2012.723823 Lee SK, 2008, ACTA OTO-LARYNGOL, V128, P66, DOI 10.1080/00016480701387108 Longo G, 2012, ACTA OTO-LARYNGOL, V132, P39, DOI 10.3109/00016489.2011.619570 Maes L, 2011, INT J AUDIOL, V50, P566, DOI 10.3109/14992027.2011.576706 Maes L, 2009, CLIN NEUROPHYSIOL, V120, P594, DOI 10.1016/j.clinph.2008.11.027 Murofushi T, 2001, ARCH OTOLARYNGOL, V127, P1069 Ochi K, 2003, OTOLARYNG HEAD NECK, V129, P655, DOI 10.1016/S0194-5994(03)01578-X Ross MD, 1976, ANN OTO RHINOL LARYN, V85, P210 Seok JI, 2008, J CLIN NEUROL, V4, P107, DOI 10.3988/jcn.2008.4.3.107 Su HC, 2004, OTOL NEUROTOL, V25, P977, DOI 10.1097/00129492-200411000-00019 Tang Y, 2001, J VESTIBUL RES-EQUIL, V11, P357 Vanspauwen R, 2009, J VESTIBUL RES-EQUIL, V19, P127, DOI 10.3233/VES-2009-0358 Von Brevern M, 2005, OTOL NEUROTOL, V27, P92 Welgampola MS, 2005, NEUROLOGY, V64, P1682, DOI 10.1212/01.WNL.0000161876.20552.AA Yang WS, 2008, OTOL NEUROTOL, V29, P1162, DOI 10.1097/MAO.0b013e31818a0881 Zhang DG, 2012, INT J PEDIATR OTORHI, V76, P107, DOI 10.1016/j.ijporl.2011.10.013 NR 31 TC 0 Z9 0 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD OCT PY 2014 VL 123 IS 10 BP 686 EP 695 DI 10.1177/0003489414532778 PG 10 WC Otorhinolaryngology SC Otorhinolaryngology GA AP7MQ UT WOS:000342261800002 PM 24789801 ER PT J AU Miguel, GS Yaremchuk, K Roth, T Peterson, E AF Miguel, George S. Yaremchuk, Kathleen Roth, Thomas Peterson, Ed TI The Effect of Insomnia on Tinnitus SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE insomnia; tinnitus ID SLEEP; SUFFERERS; SEVERITY; DISTRESS AB Objective: The objective is to see how chronic tinnitus sufferers who are unmanageable to maximized medical therapy can benefit by decreasing their subjective complaints from a sleep evaluation and treatment. However, the proper identification of these particular patients has not been described well in the literature when attempting to correlate these 2 diagnoses. Thus, tinnitus patients with and without insomnia, based on ICD-9 diagnosis, were evaluated using the Tinnitus Reaction Questionnaire and Insomnia Severity Index to determine correlations between insomnia and tinnitus. Methods: Patients with a diagnosis of tinnitus and tinnitus along with insomnia who were treated at our institution from 2009 to 2011 were identified. Tinnitus Reaction Questionnaire and Insomnia Severity Index responses were obtained through written and telephone interviews. A Pearson product moment correlation was used to determine the effect of insomnia on tinnitus. Additional analyses identified whether Tinnitus Reaction Questionnaire scores were associated with a possible benefit from an evaluation for insomnia in tinnitus patients. Results: A total of 117 patients met inclusion criteria. A significant correlation was found between the Insomnia Severity Index score and Tinnitus Reaction Questionnaire severity (r = 0.64; P = .001). Tinnitus Reaction Questionnaire severity was shown to be a good predictor of sleep disturbance and good in predicting group association, especially the "emotional" subscore component (sensitivity 96.9% and specificity 55.3% for identifying tinnitus patients with insomnia). The greater the insomnia disability as exhibited by an elevated Insomnia Severity Index score, the more severe the patient's complaints were regarding the tinnitus. Conclusion: Results suggest that if the emotional score on the Tinnitus Reaction Questionnaire is 15, the Insomnia Severity Index may be useful to identify patients who may benefit from further treatment and evaluation of insomnia. The robust correlation between the Tinnitus Reaction Questionnaire and Insomnia Severity Index objectively showed that patients with insomnia have an increased emotional distress associated with their tinnitus. Both questionnaires can be used together with a high degree of specificity and sensitivity in predicting tinnitus patients with an underlying sleep disturbance. C1 [Miguel, George S.; Yaremchuk, Kathleen] Henry Ford Hosp, Dept Otolaryngol Head & Neck Surg, Detroit, MI 48202 USA. [Roth, Thomas] Henry Ford Hosp, Sect Sleep Med, Dept Pulm & Crit Care Med, Detroit, MI 48202 USA. [Peterson, Ed] Henry Ford Hosp, Dept Publ Hlth Sci, Detroit, MI 48202 USA. RP Miguel, GS (reprint author), Henry Ford Hosp, Dept Otolaryngol Head & Neck Surg, 2799 West Grand Blvd,Suite K-8, Detroit, MI 48202 USA. EM gmiguel1@hfhs.org CR ALSTER J, 1993, BIOL PSYCHIAT, V34, P84, DOI 10.1016/0006-3223(93)90260-K Asplund R, 2003, ARCH GERONTOL GERIAT, V37, P139, DOI 10.1016/S0167-4943(03)00028-1 Bastien CH, 2001, SLEEP MED, V2, P297, DOI 10.1016/S1389-9457(00)00065-4 Budd RJ, 1995, J PSYCHOSOM RES, V39, P1015, DOI 10.1016/0022-3999(95)00512-9 Folmer RL, 2000, AM J OTOLARYNG, V21, P287, DOI 10.1053/ajot.2000.9871 Heinecke K, 2008, J BEHAV MED, V31, P179, DOI 10.1007/s10865-007-9145-0 Rosenberg SI, 1998, LARYNGOSCOPE, V108, P305, DOI 10.1097/00005537-199803000-00001 Roth T, 1999, SLEEP, V22, pS354 STOUFFER JL, 1991, AM J OTOL, V12, P188 TYLER RS, 1983, J SPEECH HEAR DISORD, V48, P150 WILSON PH, 1991, J SPEECH HEAR RES, V34, P197 NR 11 TC 0 Z9 0 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD OCT PY 2014 VL 123 IS 10 BP 696 EP 700 DI 10.1177/0003489414532779 PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA AP7MQ UT WOS:000342261800003 PM 24816421 ER PT J AU Celebi, S Caglar, E Yilmaz, B Develioglu, O Topak, M Is, H Kulekci, M AF Celebi, Saban Caglar, Erdem Yilmaz, Baki Develioglu, Omer Topak, Murat Is, Halim Kulekci, Mehmet TI Does Rhinoplasty Reduce Nasal Patency? SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE rhinoplasty; nasal patency; visual analog scale; peak nasal inspiratory flowmeter ID FUNCTIONAL-OUTCOMES; VALVE; DIAGNOSIS; OSTEOTOMY; SPREADER; SURGERY AB Objective: This study aimed to evaluate the effect of rhinoplasty on subjective and objective assessment of nasal patency in patients who underwent rhinoplasty for cosmetic reasons only. Setting: Tertiary referral center. Design: Prospective, clinical study. Subject and Methods: A total of 50 adult patients who underwent rhinoplasty were included in the study. Preoperative and postoperative photographs of the nasal profile (frontal, lateral, and oblique) were obtained. The visual analog scale (VAS) was used for the subjective evaluation of nasal obstruction (0 being the minimum, 10 being the maximum amount of nasal patency). Objective evaluation of nasal obstruction was performed with a peak nasal inspiratory flowmeter (PNIF). Results: Preoperative mean VAS scores and PNIF values of the patients were 7.36 +/- 0.83 and 115.10 +/- 17.45, respectively. Postoperative mean VAS scores and PNIF values of the patients were 7.42 +/- 0.73 and 115.30 +/- 16.7, respectively. There was no statistically significant difference between any of the pre- and postoperative subjective and objective parameters (P>.05). Conclusion: Reduction rhinoplasty has been shown not to reduce nasal patency. C1 [Celebi, Saban; Caglar, Erdem; Yilmaz, Baki; Develioglu, Omer; Topak, Murat; Is, Halim; Kulekci, Mehmet] Taksim Educ & Res Hosp, Dept Otorhinolaryngol Head & Neck Surg, Istanbul, Turkey. RP Celebi, S (reprint author), Taksim Educ & Res Hosp, Dept Otorhinolaryngol Head & Neck Surg, Istanbul, Turkey. EM celebisaban@hotmail.com CR ADAMSON P, 1990, LARYNGOSCOPE, V100, P357 Chandra RK, 2009, OTOLARYNG CLIN N AM, V42, P207, DOI 10.1016/j.otc.2009.01.004 Cummings CW, 1998, OTOLARYNGOLOGY HEAD Edizer DT, 2012, EUR ARCH OTO-RHINO-L, V270, P609 Erdogan M, 2012, EUR ARCH OTO-RHINO-L, V270, P99 GRYMER LF, 1995, LARYNGOSCOPE, V105, P429, DOI 10.1288/00005537-199504000-00017 Grymer LF, 1999, LARYNGOSCOPE, V109, P936, DOI 10.1097/00005537-199906000-00018 Guyuron B, 1998, PLAST RECONSTR SURG, V102, P856, DOI 10.1097/00006534-199809030-00037 HAIGHT JSJ, 1983, LARYNGOSCOPE, V93, P49 Hilberg O, 2002, ALLERGY, V57, P5, DOI 10.1046/j.0908-665x.2001.all.doc.x Huang C, 2006, OTOLARYNG HEAD NECK, V134, P1001, DOI 10.1016/j.otohns.2005.11.047 Jang YJ, 2011, J PLAST RECONSTR AES, V64, P301, DOI 10.1016/j.bjps.2010.05.032 Kim YH, 2011, ANN PLAS SURG, V67, P464, DOI 10.1097/SAP.0b013e3182045741 Ozkul HM, 2013, J CRANIOFAC SURG, V24, P900, DOI 10.1097/SCS.0b013e318280263a Pawar SS, 2010, FACIAL PLAST SURG, V26, P320, DOI 10.1055/s-0030-1262314 Pousti SB, 2011, ISRN OTOLARYNGOL, V2011 Tahamiler R, 2009, ARCH OTOLARYNGOL, V135, P137, DOI 10.1001/archoto.2008.537 Timperley D, 2010, ARCH FACIAL PLAST S, V12, P298, DOI 10.1001/archfacial.2010.57 WEBSTER RC, 1977, ARCH OTOLARYNGOL, V103, P454 Wittkopf M, 2008, CURR OPIN OTOLARYNGO, V16, P10, DOI 10.1097/MOO.0b013e3282f396ef Xavier R, 2010, FACIAL PLAST SURG, V26, P328, DOI 10.1055/s-0030-1262316 Zoumalan RA, 2012, ARCH FACIAL PLAST S, V14, P423, DOI 10.1001/archfacial.2012.665 NR 22 TC 0 Z9 0 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD OCT PY 2014 VL 123 IS 10 BP 701 EP 704 DI 10.1177/0003489414532783 PG 4 WC Otorhinolaryngology SC Otorhinolaryngology GA AP7MQ UT WOS:000342261800004 PM 24789802 ER PT J AU Li, DW Dong, P Wu, CP Cao, PY Zhou, L AF Li, Dawei Dong, Pin Wu, Chunping Cao, Pengyu Zhou, Liang TI Notch I Overexpression Associates With Poor Prognosis in Human Laryngeal Squamous Cell Carcinoma SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE laryngeal neoplasms; Notch I; immunohistochemistry; prognosis ID SIGNALING PATHWAY; NECK-CANCER; EXPRESSION; HEAD; DIAGNOSIS AB Objective: This study aimed to investigate the expression of Notch I in human laryngeal squamous cell carcinoma (LSCC) tissues and its relationship to clinicopathologic characteristics as well as their prognostic value in LSCC. Methods: Samples from 106 patients with LSCC were analyzed for Notch I expression by immunohistochemical staining. The relationship between Notch I expression and clinicopathologic parameters was subsequently analyzed. Univariate analysis and multivariate analysis of patient survival were examined using the Kaplan-Meier method and Cox proportional hazards model, respectively. Results: We found that Notch I had positive expression in 71 of 106 cases of LSCC (66.98%), which was obviously higher than laryngeal normal tissues (P < .01) and significantly correlated with the clinical stage, lymph node metastasis, and histological grade (all Ps < .05). Univariate analysis revealed that Notch I expression tended to show an unfavorable influence on overall survival (OS) and disease-free survival (DFS) (both Ps < .01). Multivariate analysis demonstrated that Notch I was an independent prognostic factor for patients with LSCC (P < .05). Conclusion: These results reveal that Notch I expression is a potential prognostic factor for malignant progression, metastasis, and survival of LSCC patients. Furthermore, it has been demonstrated that high expression of Notch I was associated with unfavorable OS and DFS in LSCC patients. C1 [Li, Dawei; Wu, Chunping; Cao, Pengyu; Zhou, Liang] Fudan Univ, Dept Otolaryngol Head & Neck Surg, Affiliated Eye & ENT Hosp, Shanghai 20003, Peoples R China. [Dong, Pin] Shanghai Jiao Tong Univ, Dept Otolaryngol Head & Neck Surg, Affiliated Peoples Hosp 1, Shanghai 200030, Peoples R China. RP Zhou, L (reprint author), Fudan Univ, Dept Otolaryngol Head & Neck Surg, Affiliated Eye & ENT Hosp, Shanghai 20003, Peoples R China. EM zhouliang_lidawei@163.com FU China Postdoctoral Science Foundation [2013M541466] FX The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was granted by the Project funded by China Postdoctoral Science Foundation (No. 2013M541466). CR Agrawal N, 2011, SCIENCE, V333, P1154, DOI 10.1126/science.1206923 Ai Q, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0035022 Borggrefe T, 2009, CELL MOL LIFE SCI, V66, P1631, DOI 10.1007/s00018-009-8668-7 Chang HH, 2010, CLIN CANCER RES, V16, P4411, DOI 10.1158/1078-0432.CCR-09-3360 Chen H, 2011, ORAL ONCOL, V47, P472, DOI 10.1016/j.oraloncology.2011.03.016 Chu DK, 2011, CLIN CANCER RES, V17, P5686, DOI 10.1158/1078-0432.CCR-10-3196 Chu EA, 2008, OTOLARYNG CLIN N AM, V41, P673, DOI 10.1016/j.otc.2008.01.016 Gursel DB, 2012, NEUROSURGERY, V70, pN19, DOI 10.1227/01.neu.0000410937.38828.6f Hussein M R, 2001, Expert Rev Anticancer Ther, V1, P116, DOI 10.1586/14737140.1.1.116 Jiao J, 2009, ONCOL REP, V22, P815, DOI 10.3892/or_00000504 Li JJ, 2011, J LARYNGOL OTOL, V125, P1152, DOI 10.1017/S0022215111002441 Lin JT, 2010, ANN SURG ONCOL, V17, P2976, DOI 10.1245/s10434-010-1118-9 Marioni G, 2011, ACTA OTO-LARYNGOL, V131, P1220, DOI 10.3109/00016489.2011.599817 Pai SI, 2009, ANNU REV PATHOL-MECH, V4, P49, DOI 10.1146/annurev.pathol.4.110807.092158 Shao HW, 2012, ADV PHARMACOL, V65, P191, DOI 10.1016/B978-0-12-397927-8.00007-5 Yabuuchi S, 2013, CANCER LETT, V335, P41, DOI 10.1016/j.canlet.2013.01.054 Zhou L, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0057382 NR 17 TC 0 Z9 0 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD OCT PY 2014 VL 123 IS 10 BP 705 EP 710 DI 10.1177/0003489414532784 PG 6 WC Otorhinolaryngology SC Otorhinolaryngology GA AP7MQ UT WOS:000342261800005 PM 24789803 ER PT J AU Theunissen, EAR Dreschler, WA Latenstein, MN Rasch, CRN van der Baan, S de Boer, JP Balm, AJM Zuur, CL AF Theunissen, Eleonoor A. R. Dreschler, Wouter A. Latenstein, Mere N. Rasch, Coen R. N. van der Baan, Sieberen de Boer, Jan Paul Balm, Alfons J. M. Zuur, Charlotte L. TI A New Grading System for Ototoxicity in Adults SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE ototoxicity; hearing loss; grading scales; grading criteria ID LOCALLY ADVANCED HEAD; SENSORINEURAL HEARING-LOSS; NECK-CANCER; CISPLATIN CHEMORADIATION; INTERNATIONAL SOCIETY; AUDITORY FUNCTION; CHILDREN; CHEMORADIOTHERAPY; RADIOTHERAPY; THRESHOLD AB Objective: This study aimed to propose an ototoxicity grading system sensitive to the effect of ototoxicity on specific daily life situations like speech intelligibility and the perception of ultra-high sounds and to test its feasibility compared to current criteria. Methods: Pure tone averages (PTAs) for speech perception (1-2-4 kHz) and ultra-high frequencies (8-10-12.5 kHz) were incorporated. Threshold shift and hearing level posttreatment were taken into account. Criteria were tested on head and neck cancer patients treated with (chemo-)radiotherapy ([C]RT) and compared with the Common Terminology Criteria for Adverse Events version 4 (CTCAEv4) and the American Speech-Language-Hearing Association criteria (ASHA). Results: Grades 1 and 2 were based on threshold shifts from baseline (in dB) and subjective complaints. Grades 3 and 4 were defined as treatment-induced hearing loss of 35 dB at PTA 1-2-4 kHz and >= 70 dB at PTA 1-2-4 kHz, respectively. In high-dose cisplatin CRT incidences by the new criteria, CTCAEv4 and ASHA were comparable (78%-88%). In RT and low-dose cisplatin CRT, incidences were 36% to 39% in the new criteria versus 22% to 53% in CTCAEv4 and ASHA. Conclusion: The new criteria show an increased sensitivity to ototoxicity compared to CTCAEv4 and ASHA and provide insight into the effect of hearing loss on certain daily life situations. The new grading system seems feasible for clinic and research purposes. C1 [Theunissen, Eleonoor A. R.; Latenstein, Mere N.; Balm, Alfons J. M.; Zuur, Charlotte L.] Netherlands Canc Inst, Dept Head & Neck Oncol & Surg, NL-1066 CX Amsterdam, Netherlands. [Dreschler, Wouter A.] Univ Amsterdam, Acad Med Ctr, Dept Audiol, NL-1105 AZ Amsterdam, Netherlands. [Dreschler, Wouter A.; van der Baan, Sieberen] Univ Amsterdam, Acad Med Ctr, Dept Otorhinolaryngol, NL-1105 AZ Amsterdam, Netherlands. [Rasch, Coen R. N.] Univ Amsterdam, Acad Med Ctr, Dept Radiat Oncol, NL-1105 AZ Amsterdam, Netherlands. [de Boer, Jan Paul] Netherlands Canc Inst, Dept Med Oncol, NL-1066 CX Amsterdam, Netherlands. RP Theunissen, EAR (reprint author), Netherlands Canc Inst, Dept Head & Neck Oncol & Surg, Plesmanlaan 121, NL-1066 CX Amsterdam, Netherlands. EM n.theunissen@nki.nl FU Strating Foundation FX The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: Strating Foundation. CR American Speech-Language-Hearing Association, 1994, ASHA, V36, P11 Bhandare N, 2010, INT J RADIAT ONCOL, V76, pS50, DOI 10.1016/j.ijrobp.2009.04.096 Brock PR, 2012, J CLIN ONCOL, V30, P2408, DOI 10.1200/JCO.2011.39.1110 BROCK PR, 1991, MED PEDIATR ONCOL, V19, P295, DOI 10.1002/mpo.2950190415 Chang KW, 2011, LARYNGOSCOPE, V121, P2649, DOI 10.1002/lary.22376 Chang KW, 2010, J CLIN ONCOL, V28, P1788, DOI 10.1200/JCO.2009.24.4228 Dell'Aringa AHB, 2009, RADIAT ONCOL, V4, DOI 10.1186/1748-717X-4-53 Ding DL, 2012, ANAT REC, V295, P1851, DOI 10.1002/ar.22577 Dobie RA, 2005, EAR HEARING, V26, P62, DOI 10.1097/00003446-200502000-00006 FAUSTI SA, 1984, CANCER, V53, P224, DOI 10.1002/1097-0142(19840115)53:2<224::AID-CNCR2820530207>3.0.CO;2-D FAUSTI SA, 1979, J ACOUST SOC AM, V66, P1713, DOI 10.1121/1.383643 Gurgel RK, 2012, OTOLARYNG HEAD NECK, V147, P102, DOI 10.1177/0194599812437156 Gurgel RK, 2012, OTOLARYNG HEAD NECK, V147, P803, DOI 10.1177/0194599812458401 Gurney JG, 2012, J CLIN ONCOL, V30, P2303, DOI 10.1200/JCO.2011.41.3187 International Organization for Standardization, 2000, 70292000E ISO Jereczek-Fossa BA, 2003, CANCER TREAT REV, V29, P417, DOI 10.1016/S0305-7372(03)00066-5 Low WK, 2006, J CLIN ONCOL, V24, P1904, DOI 10.1200/JCO.2005.05.0096 Mueller HG, 1990, HEAR J, V43, P1 Neuwelt EA, 2010, J CLIN ONCOL, V28, P1630, DOI 10.1200/JCO.2009.26.7872 NEWMAN CW, 1990, EAR HEARING, V11, P430, DOI 10.1097/00003446-199012000-00004 Obasikene G, 2012, NIGER J CLIN PRACT, V15, P453, DOI 10.4103/1119-3077.104527 PAVLOVIC CV, 1984, J ACOUST SOC AM, V75, P1253, DOI 10.1121/1.390731 Petsuksiri J, 2011, RADIAT ONCOL, V6, DOI 10.1186/1748-717X-6-19 Prestes Raquel, 2009, Int Tinnitus J, V15, P134 Schacht J, 2012, ANAT REC, V295, P1837, DOI 10.1002/ar.22578 US Department of Health and Human Services National Institute of Health National Cancer Institute, COMM TERM CRIT ADV E Vyskocil A, 2012, TOXICOL IND HEALTH, V28, P796, DOI 10.1177/0748233711425067 Zuur CL, 2008, RADIOTHER ONCOL, V89, P38, DOI 10.1016/j.radonc.2008.06.003 Zuur CL, 2009, INT J RADIAT ONCOL, V74, P490, DOI 10.1016/j.ijrobp.2008.08.011 Zuur CL, 2007, INT J RADIAT ONCOL, V68, P1320, DOI 10.1016/j.ijropb.2007.01.042 Zuur CL, 2006, AUDIOL NEURO-OTOL, V11, P318, DOI 10.1159/000095818 Zuur CL, 2007, J CLIN ONCOL, V25, P3759, DOI 10.1200/JCO.2006.08.9540 NR 32 TC 0 Z9 0 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD OCT PY 2014 VL 123 IS 10 BP 711 EP 718 DI 10.1177/0003489414534010 PG 8 WC Otorhinolaryngology SC Otorhinolaryngology GA AP7MQ UT WOS:000342261800006 PM 24820112 ER PT J AU Rogers, DJ Collins, C Carroll, R Yager, P Cummings, B Raol, N Setlur, J Maturo, S Tremblay, S Quinones, E Noviski, N Hartnick, CJ AF Rogers, Derek J. Collins, Corey Carroll, Ryan Yager, Phoebe Cummings, Brian Raol, Nikhila Setlur, Jennifer Maturo, Stephen Tremblay, Sarah Quinones, Ernesto Noviski, Natan Hartnick, Christopher J. TI Operation Airway: The First Sustainable, Multidisciplinary, Pediatric Airway Surgical Mission SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE Operation Airway; pediatric; surgical; mission ID TRACHEOSTOMY; EXPERIENCE AB Objective: This study aimed to describe the development and implementation of the first sustainable, multidisciplinary, pediatric airway surgical mission in an underserved country. Methods: This prospective, qualitative study was conducted for the first 4 Operation Airway missions in Quito, Ecuador. The major goals of the missions were to assist children with aerodigestive abnormalities, create a sustainable program where the local team could independently provide for their own patient population, develop an educational curriculum and training program for the local team, and cultivate a collaborative approach to provide successful multidisciplinary care. Results: Twenty patients ages 4 months to 21 years were included. Twenty-three bronchoscopies, 5 salivary procedures, 2 tracheostomies, 1 T-tube placement, 1 tracheocutaneous fistula closure, 2 open granuloma excisions, and 6 laryngotracheal reconstructions (LTRs) were performed. All LTR patients were decannulated. A new type of LTR (1.5 stage) was developed to meet special mission circumstances. Two videofluoroscopic swallow studies and 40 bedside swallow evaluations were performed. One local pediatric otolaryngologist, I pediatric surgeon, 3 anesthesiologists, 7 intensivists, 16 nurses, and 2 speech-language pathologists have received training. More than 25 hours of lectures were given, and a website was created collaboratively for educational and informational dissemination (http://www.masseyeandear.org/specialties/pediatrics/pediatric-ent/airway/OperationAirway/). Conclusion: We demonstrated the successful creation of the first mission stemming from a teaching institution with the goal of developing a sustainable, autonomous surgical airway program. C1 [Rogers, Derek J.; Collins, Corey; Carroll, Ryan; Yager, Phoebe; Cummings, Brian; Raol, Nikhila; Tremblay, Sarah; Noviski, Natan; Hartnick, Christopher J.] Massachusetts Eye & Ear Infirm, Boston, MA 02114 USA. [Setlur, Jennifer] Yale New Haven Med Ctr, New Haven, CT 06504 USA. [Maturo, Stephen] Brooke Army Med Ctr, San Antonio, TX USA. [Quinones, Ernesto] Metropolitan Hosp, Quito, Ecuador. RP Hartnick, CJ (reprint author), Massachusetts Eye & Ear Infirm, 243 Charles St, Boston, MA 02114 USA. EM Christopher_Hartnick@meei.harvard.edu CR Eberlin KR, 2008, CLEFT PALATE-CRAN J, V45, P246, DOI 10.1597/07-094.1 Fisher QA, 2001, ANESTHESIOLOGY, V95, P1315, DOI 10.1097/00000542-200112000-00007 Ruiz-Razura A, 2000, PLAST RECONSTR SURG, V105, P195, DOI 10.1097/00006534-200001000-00035 Setlur J, 2013, ANN OTO RHINOL LARYN, V122, P445 SMOOT EC, 1992, CLEFT PALATE-CRAN J, V29, P444, DOI 10.1597/1545-1569(1992)029<0444:OSIAUC>2.3.CO;2 Tobias JD, 2002, SOUTHERN MED J, V95, P239 Vyas RM, 2013, VIDEO ATLAS CLEFT LI, P17 Wetmore RE, 1999, ANN OTO RHINOL LARYN, V108, P695 WETMORE RF, 1982, ANN OTO RHINOL LARYN, V91, P628 Yeow VKL, 2002, J CRANIOFAC SURG, V13, P18, DOI 10.1097/00001665-200201000-00003 NR 10 TC 1 Z9 1 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD OCT PY 2014 VL 123 IS 10 BP 726 EP 733 DI 10.1177/0003489414534012 PG 8 WC Otorhinolaryngology SC Otorhinolaryngology GA AP7MQ UT WOS:000342261800008 PM 24835243 ER PT J AU Beltrame, AM Todt, I Sprinzl, G Profant, M Schwab, B AF Beltrame, Achille M. Todt, Ingo Sprinzl, Georg Profant, Milan Schwab, Burkhard TI Consensus Statement on Round Window Vibroplasty SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE Vibrant Soundbridge; round window; vibroplasty; floating mass transducer; conductive hearing loss; mixed hearing loss ID FLOATING MASS TRANSDUCER; MIDDLE-EAR IMPLANTS; VIBRANT SOUNDBRIDGE IMPLANTATION; MIXED HEARING LOSSES; SUBTOTAL PETROSECTOMY; EXPERIENCE; STIMULATION; MULTICENTER; ATRESIA; ELECTROCOCHLEOGRAPHY AB Objective: This study aimed to review current knowledge regarding implantation of the Vibrant Soundbridge floating mass transducer (FMT) at the round window (round window vibroplasty) as well as to form a consensus on steps for a reliable, stable surgical procedure. Data Sources: Review of the literature and experimental observations by the authors. Conclusion: Round window (RW) vibroplasty has been established as a reliable procedure that produces good and stable results for patients with conductive or mixed hearing loss. The experience gained over the past few years of the authors' more than 200 implantations has led to consensus on several key points: (I) a wide and bloodless access to the middle ear with facial nerve monitoring, (2) the careful and correct identification and exposure of the round window membrane, (3) a good setup for efficient energy transition of the FMT, namely, perpendicular placement of the FMT with no contact to bone and the placement of cartilage behind the FMT to create a preloaded "spring" function, and (4) 4 points of FMT fixation: a rim of the round window bony overhang left intact both anterior and posterior to the FMT, conductor link stabilization, and cartilage behind the FMT. In addition, the FMT should be covered with soft tissue. C1 [Beltrame, Achille M.] Ctr Clin, Rovereto, Trento, Italy. [Todt, Ingo] Hosp Univ Berlin, Charite Med Sch, UKB, Dept Otolaryngol, Berlin, Germany. [Sprinzl, Georg] Landesklinikum St Poelten, St Polten, Austria. [Profant, Milan] Slovak Med Univ, Dept Otorhinolaryngol, Bratislava, Slovakia. [Schwab, Burkhard] Hannover Med Sch, Dept Otorhinolaryngol, Hannover, Germany. RP Todt, I (reprint author), Charite, UKB, Dept Otolaryngol, Warener Str 7, D-12683 Berlin, Germany. EM todt@gmx.net CR Arnold A, 2010, OTOL NEUROTOL, V31, P122, DOI 10.1097/MAO.0b013e3181c34ee0 Barillari M, 2012, RADIOL MED, V117, P488, DOI 10.1007/s11547-011-0751-0 Baumgartner WD, 2010, ADV OTO-RHINO-LARYNG, V69, P38, DOI 10.1159/000318521 Beleites T, 2011, OTOL NEUROTOL, V32, P1468, DOI 10.1097/MAO.0b013e3182380621 Beltrame AM, 2009, OTOL NEUROTOL, V30, P194, DOI 10.1097/MAO.0b013e318180a495 Bernardeschi D, 2011, AUDIOL NEURO-OTOL, V16, P381, DOI 10.1159/000322647 Boheim K, 2012, ACTA OTO-LARYNGOL, V132, P1042, DOI 10.3109/00016489.2012.684701 Bruschini L, 2009, OTOL NEUROTOL, V30, P950, DOI 10.1097/MAO.0b013e3181b04d35 BUCKINGHAM RA, 1992, ANN OTO RHINOL LARYN, V101, P755 Canale A, 2014, EUR ARCH OTO-RHINO-L, V271, P2637, DOI 10.1007/s00405-013-2752-1 Cerini R, 2008, RADIOL MED, V113, P265, DOI [10.1007/s11547-008-0244-y, 10.1007/s111547-008-0244-y] Claros P, 2013, ACTA OTO-LARYNGOL, V133, P612, DOI 10.3109/00016489.2013.765969 Colletti L, 2013, OTOLARYNG HEAD NECK, V149, P134, DOI 10.1177/0194599813486255 Colletti L, 2011, OTOL NEUROTOL, V32, P108, DOI 10.1097/MAO.0b013e3181ff752a Colletti V, 2009, ACTA OTO-LARYNGOL, V129, P449, DOI 10.1080/00016480802642070 Colletti V, 2012, OTOLARYNG HEAD NECK, V146, P633, DOI 10.1177/0194599811430808 Colletti V, 2006, INT J AUDIOL, V45, P600, DOI 10.1080/14992020600840903 Dahmani-Causse M, 2011, EUR ANN OTORHINOLARY, V128, P230, DOI 10.1016/j.anorl.2011.02.016 Dumon T, 2009, Rev Laryngol Otol Rhinol (Bord), V130, P75 Edfeldt L, 2013, ACTA OTO-LARYNGOL, V133, P814, DOI 10.3109/00016489.2013.780294 Faccioli N, 2009, RADIOL MED, V114, P1308, DOI 10.1007/s11547-009-0462-y Frenzel H, 2009, LARYNGOSCOPE, V119, P67, DOI 10.1002/lary.20036 Guldner C, 2013, CLIN OTOLARYNGOL, V38, P217, DOI 10.1111/coa.12127 Gunduz B, 2012, ACTA OTO-LARYNGOL, V132, P1306, DOI 10.3109/00016489.2012.702353 Holland NJ, 2010, HEARING RES, V263, P239, DOI 10.1016/j.heares.2010.03.029 Iwasaki S, 2012, ACTA OTO-LARYNGOL, V132, P676, DOI 10.3109/00016489.2011.649492 Kiefer J, 2006, ORL J OTO-RHINO-LARY, V68, P378, DOI 10.1159/000095282 Linder T, 2009, OTOL NEUROTOL, V30, P41, DOI 10.1097/MAO.0b013e31818be812 Luetje CM, 2002, OTOLARYNG HEAD NECK, V126, P97, DOI 10.1067/mhn.2002.122182 Mandala M, 2011, OTOL NEUROTOL, V32, P1250, DOI 10.1097/MAO.0b013e31822e9513 Marino R, 2013, INT J AUDIOL, V52, P209, DOI 10.3109/14992027.2012.750431 Mlynski R, 2014, EUR ARCH OTO-RHINO-L, V271, P665, DOI 10.1007/s00405-013-2457-5 Mlynski R., 2010, OPERATIVE TECHNIQUES, V21, P272, DOI 10.1016/j.otot.2010.10.006 Nakajima HH, 2010, OTOL NEUROTOL, V31, P506, DOI 10.1097/MAO.0b013e3181c0ea9f Pennings RJE, 2010, OTOL NEUROTOL, V31, P998, DOI 10.1097/MAO.0b013e3181e8fc21 Rajan GP, 2011, OTOL NEUROTOL, V32, P271, DOI 10.1097/MAO.0b013e318206fda1 Roland PS, 2007, LARYNGOSCOPE, V117, P1397, DOI 10.1097/MLG.0b013e318064e891 Shimizu Y, 2011, OTOL NEUROTOL, V32, P98, DOI 10.1097/MAO.0b013e3181f7ad76 Skarzynski H, 2014, EUR ARCH OTO-RHINO-L, V271, P477, DOI 10.1007/s00405-013-2432-1 Streitberger C, 2009, Rev Laryngol Otol Rhinol (Bord), V130, P83 Todt I, 2013, THESCIENTIFICWORLDJO, V2013 Verhaegen VJO, 2010, OTOL NEUROTOL, V31, P1365, DOI 10.1097/MAO.0b013e3181f0c612 Verhaert N, 2013, EUR ARCH OTO-RHINO-L, V270, P1243, DOI 10.1007/s00405-012-2113-5 Zernotti ME, 2013, ACTA OTO-LARYNGOL, V133, P569, DOI 10.3109/00016489.2012.762117 NR 44 TC 1 Z9 1 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD OCT PY 2014 VL 123 IS 10 BP 734 EP 740 DI 10.1177/0003489414534013 PG 7 WC Otorhinolaryngology SC Otorhinolaryngology GA AP7MQ UT WOS:000342261800009 PM 24842869 ER PT J AU Leder, SB Suiter, DM AF Leder, Steven B. Suiter, Debra M. TI Five Days of Successful Oral Alimentation for Hospitalized Patients Based Upon Passing the Yale Swallow Protocol SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE aspiration risk; deglutition; deglutition disorders; oral alimentation; swallow screening ID ASPIRATION; VALIDATION; CHALLENGE; DYSPHAGIA AB Objective: This study aimed to determine the success of oral alimentation and patient retention rate 1 to 5 days after passing the Yale Swallow Protocol. Methods: Participants were 200 consecutive acute care inpatients referred for swallow assessment. Inclusion criteria were adequate cognitive abilities to participate safely, completing an oral mechanism examination, and passing the 3-ounce water swallow challenge. Exclusion criteria were altered mental status, failing the 3-ounce challenge, preadmission dysphagia, head-of-bed restrictions < 30 degrees, and a tracheotomy tube. Electronic medical record monitoring post-protocol passing for 1 to 5 consecutive days determined success of oral alimentation and retention rate. Results: All patients who remained medically and neurologically stable drank thin liquids and ate successfully 1 to 5 days after passing the protocol. Mean (SD) volume of liquid ingested per day was 474.2 (435.5) cc. Patient retention declined steadily from day of testing (n = 200) through post-testing day 5 (n = 95). Conclusion: Passing the Yale Swallow Protocol allowed for initial determination of aspiration risk followed by successful oral alimentation for 1 to 5 days in medically and neurologically stable acute care hospitalized patients and without the need for instrumental dysphagia testing. The decline in patient retention was expected because of increasingly rapid transit through the acute care setting, which often renders longer follow-up problematic. C1 [Leder, Steven B.] Yale Univ, Sch Med, Dept Surg, Otolaryngol Sect, New Haven, CT 06520 USA. [Suiter, Debra M.] Vet Affairs Med Ctr, Memphis, TN USA. RP Leder, SB (reprint author), Yale Univ, Sch Med, Dept Surg, Otolaryngol Sect, POB 208041, New Haven, CT 06520 USA. EM steven.leder@yale.edu CR Altman KW, 2010, ARCH OTOLARYNGOL, V136, P784, DOI 10.1001/archoto.2010.129 COCHRANE AL, 1971, BRIT MED BULL, V27, P3 DEPIPPO KL, 1992, ARCH NEUROL-CHICAGO, V49, P1259 Fattal M, 2011, OTOLARYNG HEAD NECK, V145, P796, DOI 10.1177/0194599811417067 Heffner JE, 2010, CHEST, V137, P509, DOI 10.1378/chest.09-2477 Kertscher B, 2014, DYSPHAGIA, V29, P204, DOI 10.1007/s00455-013-9490-9 Leder SB, 2011, J TRAUMA, V70, P1203, DOI 10.1097/TA.0b013e3181fc607a Leder SB, 2012, QJM-INT J MED, V105, P257, DOI 10.1093/qjmed/hcr193 Leder SB, 2013, DYSPHAGIA, V28, P370, DOI 10.1007/s00455-012-9442-9 Leder SB, 2009, GERONTOLOGY, V55, P714, DOI 10.1159/000235824 Leder SB, 2009, DYSPHAGIA, V24, P290, DOI 10.1007/s00455-008-9204-x Leder SB, 2013, DYSPHAGIA, V28, P58, DOI 10.1007/s00455-012-9412-2 Leder SB, 2012, TOP STROKE REHABIL, V9, P40 Leder SB, 2014, YALE SWALLOW PROTOCO Leder SB, 2011, DYSPHAGIA, V26, P304, DOI 10.1007/s00455-010-9312-2 Leder SB, 2008, ARCH PHYS MED REHAB, V89, P648, DOI 10.1016/j.apmr.2007.09.038 Suiter DM, 2008, DYSPHAGIA, V23, P244, DOI 10.1007/s00455-007-9127-y Suiter DM, 2014, DYSPHAGIA, V29, P199, DOI 10.1007/s00455-013-9488-3 Suiter DM, 2009, OTOLARYNG HEAD NECK, V140, P187, DOI 10.1016/j.otohns.2008.11.016 Warner HL, 2013, J CLIN NURSING, DOI 10.1111.jocn.12340 NR 20 TC 0 Z9 0 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD SEP PY 2014 VL 123 IS 9 BP 609 EP 613 DI 10.1177/0003489414525589 PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA AN4TH UT WOS:000340580900002 PM 24634151 ER PT J AU Stevens, MN Hullar, TE AF Stevens, Madelyn N. Hullar, Timothy E. TI Improvement in Sensorineural Hearing Loss During Pregnancy SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE audiogram; auditory; hearing; hormone; Meniere's; migraine; pregnancy; threshold; vestibular ID MENIERES-DISEASE; VESTIBULAR MIGRAINE; AUDITORY FUNCTION; ESTROGEN; WOMEN; SYMPTOMS; RECEPTOR; THERAPY; CYCLE AB Objective: Hearing loss is known to occur in some pregnant women, but improvement in sensorineural thresholds has not been audiometrically characterized. Here, we describe a patient with a history of Meniere's disease and vestibular migraine who experienced temporary recovery of her hearing during pregnancy. Methods: Audiograms were obtained from a 31-year-old female over the course of 2 successive pregnancies. Results: Audiograms revealed a substantial improvement in hearing by the third trimester during each pregnancy, with a rapid return to baseline thresholds after delivery. Conclusion: This case is unique in documenting improvements in hearing thresholds during pregnancy and substantiates the effects of hormonal changes on hearing thresholds in humans. It raises the intriguing possibility of hormonal therapy as a treatment for sensorineural hearing loss in specific clinical situations. C1 [Stevens, Madelyn N.; Hullar, Timothy E.] Washington Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, St Louis, MO 63110 USA. RP Hullar, TE (reprint author), Washington Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, 660 South Euclid Ave 8115, St Louis, MO 63110 USA. EM hullart@ent.wustl.edu FU NIH [NIDCD T35 008675] FX The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: Supported in part by grant NIH NIDCD T35 008675. CR Al-Mana D, 2010, HEARING RES, V268, P114, DOI 10.1016/j.heares.2010.05.007 Al-Mana D, 2008, NEUROSCIENCE, V153, P881, DOI 10.1016/j.neuroscience.2008.02.077 Andrews JC, 2010, OTOLARYNG CLIN N AM, V43, P1029, DOI 10.1016/j.otc.2010.05.012 ANDREYKO JL, 1989, OBSTET GYNECOL, V74, P506 Arck PC, 2013, NAT MED, V19, P548, DOI 10.1038/nm.3160 Bourke CH, 2012, HORM BEHAV, V62, P210, DOI 10.1016/j.yhbeh.2012.02.024 Digre KB, 2013, CLIN OBSTET GYNECOL, V56, P317, DOI 10.1097/GRF.0b013e31828f25e6 Eckhard A, 2012, MOL ASPECTS MED, V33, P612, DOI 10.1016/j.mam.2012.06.004 Guimaraes P, 2006, P NATL ACAD SCI USA, V103, P14246, DOI 10.1073/pnas.0606891103 Hederstierna C, 2009, HEARING RES, V252, P3, DOI 10.1016/j.heares.2008.11.006 Hederstierna C, 2010, HEARING RES, V259, P31, DOI 10.1016/j.heares.2009.09.009 Kilicdag EB, 2004, AM J OBSTET GYNECOL, V190, P77, DOI 10.1016/j.ajpg.2003.06.001 Meltser I, 2008, J CLIN INVEST, V118, P1563, DOI 10.1172/JCI32796 MILLER M H, 1967, Journal of Auditory Research, V7, P373 MONSELL EM, 1995, OTOLARYNG HEAD NECK, V113, P181 Morse GG, 2001, NURS RES, V50, P286, DOI 10.1097/00006199-200109000-00006 Neff BA, 2012, OTOL NEUROTOL, V33, P1235, DOI 10.1097/MAO.0b013e31825d644a Nolan LS, 2013, NEUROBIOL AGING, V34, DOI 10.1016/j.neurobiolaging.2013.02.009 Phillips JS, 2011, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD008514.pub2 PRICE TM, 1994, ARCH OTOLARYNGOL, V120, P209 Radtke A, 2012, NEUROLOGY, V79, P1607, DOI 10.1212/WNL.0b013e31826e264f Radtke A, 2011, CEPHALALGIA, V31, P906, DOI 10.1177/0333102411405228 Schmidt PMD, 2010, BRAZ J OTORHINOLAR, V76, P29, DOI 10.1590/S1808-86942010000100006 Sennaroglu G, 2001, J LARYNGOL OTOL, V115, P617 Souaid JP, 2001, J OTOLARYNGOL, V30, P246, DOI 10.2310/7070.2001.20181 Stachenfeld NS, 2002, AM J PHYSIOL-ENDOC M, V283, pE711, DOI 10.1152/ajpendo.00192.2002 Stachenfeld NS, 2001, AM J PHYSIOL-REG I, V281, pR1319 Tozer BS, 2006, MAYO CLIN PROC, V81, P1086 Uchide K, 1997, ORL J OTO-RHINO-LARY, V59, P292 VANDEELEN GW, 1986, ORL J OTO-RHINO-LARY, V48, P287 NR 30 TC 0 Z9 0 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD SEP PY 2014 VL 123 IS 9 BP 614 EP 618 DI 10.1177/0003489414525590 PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA AN4TH UT WOS:000340580900003 PM 24682732 ER PT J AU Banuchi, V Cohen, JC Kacker, A AF Banuchi, Victoria Cohen, Justin C. Kacker, Ashutosh TI Safety of Concurrent Nasal and Oropharyngeal Surgery for Obstructive Sleep Apnea SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE complications; obstructive sleep apnea; septoplasty; uvulopalatopharyngoplasty AB Objective: This study evaluated for increased complications or risk associated with concurrent nasal and oropharyngeal surgeries to treat patients with obstructive sleep apnea (OSA). Study Design: Retrospective chart review. Methods: We performed a retrospective chart review on consecutive patients between 2006 and 2011 who underwent either simultaneous nasal and pharyngeal surgery (group 1) or pharyngeal surgery alone (group 2) to treat OSA. We compared the length of hospitalization and the rate of complications in both groups. Results: Group 1 consisted of 20 patients, all male, with ages ranging from 25 to 72 years (average, 35 years) and apnea-hypopnea index (AHI) from 2.6 to 119 (average, 52.2). Group 2 consisted of 20 patients, 1 female, with ages ranging from 23 to 71 years (average, 37 years) and AHI from 10 to 101 (average, 46.1). In group 1, 30% of patients were ambulatory compared to 25% of patients in group 2. In all cases, the nonambulatory patients were observed for only 1 night. The rate of complications in both groups was 10% (2 out of 20 in each group). Both complications in group 1 were post-tonsillectomy bleeds. In group 2, 1 patient had a post-tonsillectomy bleed and 1 patient was readmitted with dehydration due to poor pain control. There was no statistically significant difference in length of hospitalization or rate of complications in these 2 groups. Conclusion: Performing concurrent nasal and oropharyngeal surgery for OSA was safe when compared to oropharyngeal surgery alone in our cohort and, with careful selection criteria, can even be done in the ambulatory setting. Large, multi-institutional investigations are indicated. C1 [Banuchi, Victoria; Cohen, Justin C.; Kacker, Ashutosh] Weill Cornell Med Coll, New York, NY 10032 USA. RP Banuchi, V (reprint author), Weill Cornell Med Coll, 180 Ft Washington Ave,Room HP 8-814, New York, NY 10032 USA. EM veb9010@nyp.org CR Choi JH, 2011, OTOLARYNG HEAD NECK, V144, P994, DOI 10.1177/0194599811398194 Li HY, 2005, ACTA OTO-LARYNGOL, V125, P298, DOI 10.1080/00016480410022831 Li HY, 2008, ARCH OTOLARYNGOL, V134, P429, DOI 10.1001/archotol.134.4.429 Li Yan-ru, 2006, Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi, V41, P437 Mickelson SA, 1998, OTOLARYNG HEAD NECK, V119, P352, DOI 10.1016/S0194-5998(98)70077-4 Nowak C, 2003, Ann Otolaryngol Chir Cervicofac, V120, P161 Sieśkiewicz Andrzej, 2007, Pol Merkur Lekarski, V22, P130 NR 7 TC 0 Z9 0 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD SEP PY 2014 VL 123 IS 9 BP 619 EP 622 DI 10.1177/0003489414525587 PG 4 WC Otorhinolaryngology SC Otorhinolaryngology GA AN4TH UT WOS:000340580900004 PM 24634156 ER PT J AU Ozturan, O Dogan, R Aksoy, F Tugrul, S Eren, SB AF Ozturan, Orhan Dogan, Remzi Aksoy, Fadlullah Tugrul, Selahattin Eren, Sabri Baki TI Dorsal Approach to Septum in External Septorhinoplasty SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE septorhinoplasty; septum; approach; dorsal; caudal ID NASAL-SEPTUM; SURGERY; SEPTOPLASTY AB Objective: During external septorhinoplasty, access from the caudal septum into subperichondrial space often poses difficulties and challenges for proper elevation of the mucoperichondrial flap. The dorsal and caudal approaches were compared with respect to duration and mucosal integrity. Methods: The caudal approach was applied in 52 patients and the dorsal approach in 50 patients. The duration was recorded starting with septal incision, until the end of the completion of the bilateral subperichondrial and subperiosteal elevation. The mucosal integrity was inspected for any mucosal damage. Results: The elevation durations for the caudal approach and the dorsal approach were 450.3 seconds and 232 seconds, respectively. The impairment in mucosal integrity was observed in 33 cases (63%) with the caudal approach and in 16 cases (32%) with the dorsal approach. Statistically significant differences were found between the 2 groups in terms of duration and mucosal integrity. Conclusion: The dorsal approach is a more advantageous choice that provides easier, safer, and faster access, ensures a comfortable and effective subperichondrial elevation, and is more advantageous for the protection of mucosal integrity as compared to the caudal approach from the anterior septal angle, since the perichondrium in the caudal septum is more attached to the underlying cartilage. C1 [Ozturan, Orhan; Dogan, Remzi; Aksoy, Fadlullah; Tugrul, Selahattin; Eren, Sabri Baki] Bezmialem Vakif Univ, Dept Otorhinolaryngol, Istanbul, Turkey. RP Dogan, R (reprint author), Bezmialem Vakif Univ, Fac Med, Dept Otorhinolaryngol, Istanbul, Turkey. EM dr.remzidogan@gmail.com RI OZTURAN, ORHAN/B-4984-2015 OI OZTURAN, ORHAN/0000-0002-6129-8627 CR Aksoy F, 2012, J LARYNGOL OTOL, V126, P38, DOI 10.1017/S0022215111002404 Bateman ND, 2003, J LARYNGOL OTOL, V117, P186 Baumann I, 2007, RHINOLOGY, V45, P220 BEESON WH, 1987, OTOLARYNG CLIN N AM, V20, P743 COTTLE MH, 1958, ARCHIV OTOLARYNGOL, V68, P301 Daniel RK, 1999, RHINOPLASTY ATLAS SU Dobratz EJ, 2009, OTOLARYNG CLIN N AM, V42, P527, DOI 10.1016/j.otc.2009.03.003 Fattahi T, 2011, J ORAL MAXILLOFAC SU, V69, P528 Freer OT, 1902, JAMA-J AM MED ASSOC, V38, P636 Gunter JP, 2002, DALLAS RHINOPLASTY N Ketcham AS, 2010, OTOLARYNG CLIN N AM, V43, P897, DOI 10.1016/j.otc.2010.04.013 Killian G, 1904, ARCH LARYNGOL RHINOL, V16, P364 Schwab J A, 1997, Facial Plast Surg, V13, P3, DOI 10.1055/s-2008-1064461 Tahery J, 2004, J LARYNGOL OTOL, V118, P715 Tebbetts JB, 1998, PRIMARY RHINOPLASTY Toriumi Dean M, 2002, Aesthet Surg J, V22, P72, DOI 10.1067/maj.2002.122071 Vuyk H. D., 1993, Rhinology (Utrecht), V31, P175 NR 17 TC 0 Z9 0 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD SEP PY 2014 VL 123 IS 9 BP 623 EP 628 DI 10.1177/0003489414528868 PG 6 WC Otorhinolaryngology SC Otorhinolaryngology GA AN4TH UT WOS:000340580900005 PM 24723667 ER PT J AU Hathaway, B Vaezi, A Egloff, AM Smith, L Wasserman-Wincko, T Johnson, JT AF Hathaway, Bridget Vaezi, Alec Egloff, Ann Marie Smith, Libby Wasserman-Wincko, Tamara Johnson, Jonas T. TI Frailty Measurements and Dysphagia in the Outpatient Setting SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE aspiration; frailty; grip strength; oropharyngeal dysphagia ID HANDGRIP STRENGTH; GRIP STRENGTH; OLDER-ADULTS; TONGUE; PERFORMANCE; PREDICTOR; PNEUMONIA; MORTALITY; SPEED; COST AB Objective: Deconditioning and frailty may contribute to dysphagia and aspiration. Early identification of patients at risk of aspiration is important. Aspiration prevention would lead to reduced morbidity and health care costs. We therefore wondered whether objective measurements of frailty could help identify patients at risk for dysphagia and aspiration. Methods: Consecutive patients (n = 183) were enrolled. Patient characteristics and objective measures of frailty were recorded prospectively. Variables tested included age, body mass index, grip strength, and 5 meter walk pace. Statistical analysis tested for association between these parameters and dysphagia or aspiration, diagnosed by instrumental swallowing examination. Results: Of variables tested for association with grip strength, only age category (P = .003) and ambulatory status (P < .001) were significantly associated with grip strength in linear regression models. Whereas walk speed was not associated with dysphagia or aspiration, ambulatory status was significantly associated with dysphagia and aspiration in multivariable model building. Conclusion: Nonambulatory status is a predictor of aspiration and should be included in risk assessments for dysphagia. The relationship between frailty and dysphagia deserves further investigation. Frailty assessments may help identify those at risk for complications of dysphagia. C1 [Hathaway, Bridget; Egloff, Ann Marie; Smith, Libby; Wasserman-Wincko, Tamara; Johnson, Jonas T.] Univ Pittsburgh, Sch Med, Dept Otolaryngol, Pittsburgh, PA USA. [Vaezi, Alec] Univ Massachusetts, Dept Otolaryngol, Worcester, MA 01605 USA. [Egloff, Ann Marie] Univ Pittsburgh, Sch Med, Dept Microbiol & Mol Genet, Pittsburgh, PA USA. RP Hathaway, B (reprint author), Eye & Ear Inst Pittsburgh, 200 Lothrop St,Suite 500, Pittsburgh, PA 15213 USA. EM hathbc@upmc.edu FU Department of Otolaryngology, University of Pittsburgh School of Medicine FX The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: Support was provided by the Department of Otolaryngology, University of Pittsburgh School of Medicine. CR Adams V, 2013, DYSPHAGIA, V28, P350, DOI 10.1007/s00455-013-9451-3 Buehring B, 2013, J AM GERIATR SOC, V61, P418, DOI 10.1111/jgs.12124 Butler SG, 2011, J GERONTOL A-BIOL, V66, P452, DOI 10.1093/gerona/glq234 Chen CH, 2011, J CARDIOTHORAC SURG, V6, DOI 10.1186/1749-8090-6-98 Fried L, 2009, HAZZARDS GERIATRIC M Rantanen T, 1999, JAMA-J AM MED ASSOC, V281, P558, DOI 10.1001/jama.281.6.558 Sabia S, 2014, J GERONTOL A-BIOL, V69, P354, DOI 10.1093/gerona/glt114 Sasaki H, 2007, AM J MED, V120, P337, DOI 10.1016/j.amjmed.2006.04.018 Semenov YR, 2012, LARYNGOSCOPE, V122, P1994, DOI 10.1002/lary.23446 Studenski S, 2011, JAMA-J AM MED ASSOC, V305, P50, DOI 10.1001/jama.2010.1923 Syddall H, 2003, AGE AGEING, V32, P650, DOI 10.1093/ageing/afg111 Wilson RD, 2012, J STROKE CEREBROVASC, V21, P61, DOI 10.1016/j.jstrokecerebrovasdis.2010.05.002 NR 12 TC 1 Z9 1 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD SEP PY 2014 VL 123 IS 9 BP 629 EP 635 DI 10.1177/0003489414528669 PG 7 WC Otorhinolaryngology SC Otorhinolaryngology GA AN4TH UT WOS:000340580900006 PM 24707011 ER PT J AU Muhanna, N Peleg, U Schwartz, Y Shaul, H Perez, R Sichel, JY AF Muhanna, Nidal Peleg, Uri Schwartz, Yehuda Shaul, Hanan Perez, Ronen Sichel, Jean-Yves TI Harmonic Scalpel Assisted Superficial Parotidectomy SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE facial nerve paresis; Harmonic Scalpel; length of surgery; parotidectomy ID VESSEL SEALING SYSTEM; ULTRASONICALLY ACTIVATED SCALPEL; THYROID-SURGERY; TONSILLECTOMY; LIGASURE; HEMOSTASIS; DISSECTION; LIGATION; BENIGN AB Objective: The Harmonic Scalpel (HS) has been recently widely used to perform a variety of surgical procedures. We reviewed our experience with the use of HS in superficial parotidectomy to determine the safety and efficacy of this procedure, with regard to operative time, postoperative facial nerve function, and drainage output. Study Design: Nonrandomized retrospective review. Materials and Methods: The medical records of all patients who underwent superficial parotidectomy for benign pathology at Shaare Zedek Medical Center from January 2006 to July 2009 were retrospectively reviewed. Patients with prior facial nerve weakness or prior parotid surgery or who had undergone concurrent neck dissection or total parotidectomy were excluded. Results: Fifty-eight patients were reviewed; 26 patients underwent HS parotidectonny and 32 patients underwent conventional (cold knife) parotidectomy (control group). Harmonic Scalpel assisted parotidectomy was associated with significantly decreased length of surgery from 163.12 +/- 21.8 minutes for controls to 137.3 +/- 18.6 minutes in the HS assisted group (P < .05). The incidence of temporary postoperative facial nerve paresis was significantly reduced from 43% in the controls to 23% in the HS group (P < .05). No permanent facial nerve paralysis was reported. There were differences in the overall postoperative drain output between the HS and control groups, 68 +/- 22.3 mL and 73.5 +/- 38.2 mL, respectively, but these differences did not achieve significance. Conclusion: This study shows that HS assisted superficial parotidectomy for benign pathology is a safe technique and associated with reduced surgical time and incidence of temporary postoperative facial nerve paresis compared with conventional techniques. C1 [Muhanna, Nidal; Peleg, Uri; Schwartz, Yehuda; Shaul, Hanan; Perez, Ronen; Sichel, Jean-Yves] Shaare Zedek Med Ctr, Dept Otolaryngol Head & Neck Surg, IL-91121 Jerusalem, Israel. RP Muhanna, N (reprint author), Shaare Zedek Med Ctr, Dept Otolaryngol Head & Neck Surg, POB 12248, IL-91121 Jerusalem, Israel. EM nmuhanna@gmail.com CR Blankenship DR, 2004, OTOLARYNG HEAD NECK, V131, P397, DOI 10.1016/j.otohns.2004.03.043 Bron LP, 1997, ARCH OTOLARYNGOL, V123, P1091 Carlander J, 2005, BRIT J SURG, V92, P772, DOI 10.1002/bjs.4948 Ecker T, 2010, OTOLARYNG HEAD NECK, V143, P17, DOI 10.1016/j.otohns.2010.03.018 Gaillard C, 2005, LARYNGOSCOPE, V115, P287, DOI 10.1097/01.mlg.0000154735.61775.cd He QQ, 2011, WORLD J SURG ONCOL, V9, DOI 10.1186/1477-7819-9-141 Jackson LL, 2005, LARYNGOSCOPE, V115, P1070, DOI 10.1097/01.MLG.0000163336.37077.8F LACCOURREYE H, 1994, LARYNGOSCOPE, V104, P1487 Lachanas VA, 2007, OTOLARYNG HEAD NECK, V137, P385, DOI 10.1016/j.otohns.2007.05.012 Manouras A, 2008, AM J SURG, V195, P48, DOI 10.1016/j.amjsurg.2007.01.037 Markkanen-Leppanen M, 2004, LARYNGOSCOPE, V114, P381, DOI 10.1097/00005537-200402000-00038 Markogiannakis H, 2011, SURGERY, V149, P411, DOI 10.1016/j.surg.2010.08.001 Metternich FU, 2003, LARYNGO RHINO OTOL, V82, P514 Miccoli P, 2002, SURG ENDOSC, V16, P663, DOI 10.1007/s00464-001-9117-3 Monfared A, 2002, OPER TECHN OTOLARYNG, V13, P155, DOI 10.1053/otot.2002.125987 Neumann C, 2007, OTOLARYNG HEAD NECK, V137, P378, DOI 10.1016/j.otohns.2007.05.003 Pons Y, 2009, OTOLARYNG HEAD NECK, V141, P496, DOI 10.1016/j.otohns.2009.06.745 Prgomet D, 2009, EUR ARCH OTO-RHINO-L, V266, P1965, DOI 10.1007/s00405-009-0954-3 Shemen L, 2002, OTOLARYNG HEAD NECK, V127, P284, DOI 10.1067/mhn.2002.128072 Sherman JA, 2000, BRIT J ORAL MAX SURG, V38, P530, DOI 10.1054/bjom.2000.0502 Siperstein AE, 2002, ARCH SURG-CHICAGO, V137, P137, DOI 10.1001/archsurg.137.2.137 Walker RA, 2001, OTOLARYNG HEAD NECK, V125, P449, DOI 10.1067/mhn.2001.119325 Wiatrak BJ, 2002, LARYNGOSCOPE, V112, P14 Zarebczan B, 2011, ANN SURG ONCOL, V18, P214, DOI 10.1245/s10434-010-1334-3 NR 24 TC 0 Z9 0 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD SEP PY 2014 VL 123 IS 9 BP 636 EP 640 DI 10.1177/0003489414528674 PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA AN4TH UT WOS:000340580900007 PM 24707012 ER PT J AU Hart, CK de Alarcon, A Tabangin, ME Hamilton, S Rutter, MJ Pentiuk, SP Garza, JM AF Hart, Catherine K. de Alarcon, Alessandro Tabangin, Meredith E. Hamilton, Steven Rutter, Michael J. Pentiuk, Scott P. Garza, Jose M. TI Impedance Probe Testing Prior to Pediatric Airway Reconstruction SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE airway reconstruction; subglottic stenosis; gastroesophageal reflux; impedance testing ID GASTROESOPHAGEAL-REFLUX DISEASE; LARYNGOTRACHEAL RECONSTRUCTION; SUBGLOTTIC STENOSIS; ACID; CHILDREN; INJURY; MODEL AB Objective: This study aimed to determine if preoperative impedance testing changed management and if testing was associated with surgical outcome in patients undergoing airway reconstruction. Methods: Retrospective review of patients who had impedance testing prior to airway reconstruction at a tertiary pediatric hospital from January 2010 to September 2011. Charts were reviewed for demographics, medical/surgical history, impedance testing, and surgical outcomes. Results: Fifty-seven patients were included. Forty-seven (82%) were premature. Forty-seven (82%) had a primary diagnosis of subglottic stenosis. Twenty-six (45%) had prior airway surgery. Thirty-six (63%) had gastroesophageal reflux and 21 (36%) had undergone fundoplication. Patients without fundoplication had a median 46 total reflux, 7 proximal, and 14.5 acidic events compared to a median 5 total reflux, 0 proximal, and 0. acidic events in patients with fundoplication. Impedance testing changed management in 22% (8/36) of nonfundoplication patients and 9.5% (2/21) of fundoplication patients. In unadjusted analysis, fewer fundoplication patients had successful surgery compared to those without (33% vs 67%, P = .01). Prematurity, age at surgery, and previous airway surgery were also important predictors of surgical success. Conclusion: Fewer patients than anticipated had a change in management. Impedance testing was unlikely to change management in fundoplication patients. Patients with fundoplication were less likely to have a successful outcome, suggesting that factors other than reflux influence airway reconstruction outcomes. C1 [Hart, Catherine K.; de Alarcon, Alessandro; Hamilton, Steven; Rutter, Michael J.] Cincinnati Childrens Hosp Med Ctr, Div Pediat Otolaryngol Head & Neck Surg, Cincinnati, OH 45229 USA. [Hart, Catherine K.; de Alarcon, Alessandro; Rutter, Michael J.; Pentiuk, Scott P.; Garza, Jose M.] Cincinnati Childrens Hosp Med Ctr, Aerodigest & Esophageal Ctr, Cincinnati, OH 45229 USA. [Hart, Catherine K.; de Alarcon, Alessandro; Hamilton, Steven; Rutter, Michael J.] Univ Cincinnati, Coll Med, Dept Otolaryngol Head & Neck Surg, Cincinnati, OH USA. [Tabangin, Meredith E.] Cincinnati Childrens Hosp Med Ctr, Div Biostat & Epidemiol, Cincinnati, OH 45229 USA. [Pentiuk, Scott P.; Garza, Jose M.] Cincinnati Childrens Hosp Med Ctr, Div Gastroenterol, Cincinnati, OH 45229 USA. RP Hart, CK (reprint author), Cincinnati Childrens Hosp Med Ctr, Div Pediat Otolaryngol, 3333 Burnet Ave,MLC 2018, Cincinnati, OH 45229 USA. EM catherine.hart@cchmc.org FU Institutional Clinical and Translational Science Award; NIH/NCRR [5UL1RR026314-3] FX The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This project was supported in part by an Institutional Clinical and Translational Science Award, NIH/NCRR Grant No. 5UL1RR026314-3. Its contents are solely the responsibility of the authors and do not necessarily represent the official views of the National Institutes of Health. CR Blumin JH, 2011, LARYNGOSCOPE, V121, P1266, DOI 10.1002/lary.21776 Carron JD, 2001, ARCH OTOLARYNGOL, V127, P576 Condino AA, 2006, J PEDIATR GASTR NUTR, V42, P16, DOI 10.1097/01.mpg.0000188008.66752.72 de Alarcon A, 2008, OTOLARYNG CLIN N AM, V41, P959, DOI 10.1016/j.otc.2008.04.004 Garza JM, 2011, CLIN PEDIATR, V50, P1110, DOI 10.1177/0009922811412585 GRAY S, 1987, ANN OTO RHINOL LARYN, V96, P509 KOUFMAN JA, 1991, LARYNGOSCOPE, V101, P1 LITTLE FB, 1985, ANN OTO RHINOL LARYN, V94, P516 May JG, 2011, ANN OTO RHINOL LARYN, V120, P116 Rosen R, 2011, J PEDIATR GASTR NUTR, V52, P404, DOI 10.1097/MPG.0b013e3182078081 Salvatore S, 2010, J PEDIATR-US, V157, P949, DOI 10.1016/j.jpeds.2010.07.029 Stroh BC, 1998, ARCH OTOLARYNGOL, V124, P545 Wenzl TG, 2012, J PEDIATR GASTR NUTR, V55, P230, DOI 10.1097/MPG.0b013e3182592b65 Yellon RF, 1998, LARYNGOSCOPE, V108, P854, DOI 10.1097/00005537-199806000-00014 Yellon Robert F., 2000, American Journal of Medicine, V108, p131S NR 15 TC 0 Z9 0 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD SEP PY 2014 VL 123 IS 9 BP 641 EP 646 DI 10.1177/0003489414528867 PG 6 WC Otorhinolaryngology SC Otorhinolaryngology GA AN4TH UT WOS:000340580900008 PM 24707014 ER PT J AU Bacciu, A Medina, M Ben Ammar, M D'Orazio, F Di Lella, F Russo, A Magnan, J Sanna, M AF Bacciu, Andrea Medina, Marimar Ben Ammar, Mehdi D'Orazio, Flavia Di Lella, Filippo Russo, Alessandra Magnan, Jacques Sanna, Mario TI Intraoperatively Diagnosed Cerebellopontine Angle Facial Nerve Schwannoma: How To Deal With It SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE facial schwannoma; facial nerve; cerebellopontine angle; internal auditory canal; facial nerve; management ID VESTIBULAR SCHWANNOMA; STEREOTACTIC RADIOTHERAPY; SURGICAL EXCISION; MANAGEMENT; NEUROMA; TUMORS; RADIOSURGERY; SURGERY AB Objective: This study aimed to report our experience in the management of patients with intraoperatively diagnosed intracranial facial nerve schwannomas (FNSs) and propose a decision-making strategy. Methods: Twenty-three patients with FNS of the internal auditory canal and/or cerebellopontine angle operated on between 1992 and 2012 were identified. Results: Preoperatively, all cases have been radiographically diagnosed as vestibular schwannomas. Operative procedures consisted of total tumor resection with grafting in 43.4% of patients, near-total resection leaving behind the tumor capsule overlying the facial nerve in 21.7%, total tumor resection with preservation of anatomic continuity of the facial nerve in 13%, and subtotal resection in 4.3%. Four patients (17.4%) underwent bony decompression with no tumor removal. Conclusion: Management of FNS diagnosed at surgery represents a significant clinical challenge. We considered total tumor resection with grafting when patients presented with preoperative facial nerve palsy (>= grade 111). Both subtotal and near-total tumor removal can be performed in patients with preoperative good facial function and/or large tumors with brainstem compression. Patients with small tumors who were selected for hearing preservation surgery can be considered for bony decompression. Fascicle preservation surgery may be an option when a clear cleavage plane between the tumor and the facial nerve is found. C1 [Bacciu, Andrea] Univ Hosp Parma, Dept Clin & Expt Med, Otolaryngol Unit, I-43100 Parma, Italy. [Medina, Marimar; D'Orazio, Flavia; Di Lella, Filippo; Russo, Alessandra; Sanna, Mario] Grp Otol Piacenza, Rome, Italy. [Medina, Marimar; D'Orazio, Flavia; Di Lella, Filippo; Russo, Alessandra; Sanna, Mario] Univ G dAnnunzio, Chieti, Italy. [Ben Ammar, Mehdi] Univ Tunis El Manar, Mil Hosp Tunis, Dept Neurosurg, Tunis, Tunisia. [Magnan, Jacques] Hop Univ Nord, Dept Otolaryngol, Marseille, France. RP Bacciu, A (reprint author), Univ Hosp Parma, Dept Clin & Expt Med, Otolaryngol Unit, Via Gramsci 14, I-43100 Parma, Italy. EM andreabacciu@yahoo.it CR American Academy of Otolaryngology-Head and Neck Surgery, 1995, OTOLARYNGOL HEAD NEC, V113, P179, DOI DOI 10.1016/S0194-5998(95)70101-X Angeli SI, 1997, OTOLARYNG HEAD NECK, V117, pS144, DOI 10.1016/S0194-5998(97)70084-6 Bacciu A, 2013, AUDIOL NEURO-OTOL, V18, P184, DOI 10.1159/000349990 Bacciu A, 2009, AM J OTOLARYNG, V30, P83, DOI 10.1016/j.amjoto.2008.02.010 FAGAN PA, 1993, LARYNGOSCOPE, V103, P442 Falcioni M, 2003, OTOL NEUROTOL, V24, P486, DOI 10.1097/00129492-200305000-00022 Falcioni M, 2003, OTOL NEUROTOL, V24, P942, DOI 10.1097/00129492-200311000-00021 Hillman TA, 2008, ENT-EAR NOSE THROAT, V87, P574 HOUSE JW, 1985, OTOLARYNG HEAD NECK, V93, P146 Husseini ST, 2011, LARYNGOSCOPE, V121, P923, DOI 10.1002/lary.21448 Kanzaki J, 2003, OTOL NEUROTOL, V24, P642, DOI 10.1097/00129492-200307000-00019 Kertesz TR, 2001, LARYNGOSCOPE, V111, P1250, DOI 10.1097/00005537-200107000-00020 Kida Y, 2007, J NEUROSURG, V106, P24, DOI 10.3171/jns.2007.106.1.24 Kim CS, 2003, OTOL NEUROTOL, V24, P312, DOI 10.1097/00129492-200303000-00030 Lassaletta L, 2002, SKULL BASE-INTERD AP, V12, P203, DOI 10.1055/s-2002-35752-1 Lee JD, 2007, LARYNGOSCOPE, V117, P1063, DOI 10.1097/MLG.0b013e31804b1a51 Lee WS, 2011, OTOL NEUROTOL, V32, P1548, DOI 10.1097/MAO.0b013e318232e46e LIPKIN AF, 1987, OTOLARYNG HEAD NECK, V96, P71 Litre CF, 2007, NEUROSURGERY, V60, P853, DOI 10.1227/01.NEU.0000249282.46514.DA Liu R, 2001, ANN OTO RHINOL LARYN, V110, P1025 Madhok R, 2009, NEUROSURGERY, V64, P1102, DOI 10.1227/01.NEU.0000343743.20297.FB Marzo SJ, 2009, CURR OPIN OTOLARYNGO, V17, P346, DOI 10.1097/MOO.0b013e32832ea999 McClelland S, 2007, STEREOT FUNCT NEUROS, V85, P299, DOI 10.1159/000107364 MCMENOMEY SO, 1994, AM J OTOL, V15, P307 McMonagle B, 2008, J LARYNGOL OTOL, V122, P1139, DOI 10.1017/S0022215107000667 McRackan TR, 2011, OTOL NEUROTOL, V33, P78 Mowry S, 2012, OTOL NEUROTOL, V33, P1071, DOI 10.1097/MAO.0b013e31825e7e36 Nadeau DP, 2003, OTOL NEUROTOL, V24, P317, DOI 10.1097/00129492-200303000-00031 Nishioka K, 2009, INT J RADIAT ONCOL, V75, P1415, DOI 10.1016/j.ijrobp.2008.12.063 Perez R, 2005, OTOL NEUROTOL, V26, P121, DOI 10.1097/00129492-200501000-00022 PULEC JL, 1972, LARYNGOSCOPE, V82, P1160, DOI 10.1288/00005537-197207000-00005 SALEH E, 1995, AM J OTOL, V16, P521 Sataloff R T, 1995, Ear Nose Throat J, V74, P244 Sherman JD, 2002, NEUROSURGERY, V50, P450, DOI 10.1097/00006123-200203000-00004 Wiggins RH, 2006, AM J NEURORADIOL, V27, P694 Wilkinson EP, 2011, LARYNGOSCOPE, V121, P2065, DOI 10.1002/lary.22141 NR 36 TC 0 Z9 0 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD SEP PY 2014 VL 123 IS 9 BP 647 EP 653 DI 10.1177/0003489414528673 PG 7 WC Otorhinolaryngology SC Otorhinolaryngology GA AN4TH UT WOS:000340580900009 PM 24707015 ER PT J AU Sood, A Taheri, MR Joshi, AS AF Sood, Amit Taheri, M. Reza Joshi, Arjun S. TI Preventing Cuff Rupture During Tracheostomy: Importance of Endotracheal Tube Positioning SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE endotracheal tube position; ETT; tracheostomy complications; endotracheal tube; cuff-rupture; quality improvement; tracheostomy; resident training ID DIFFICULT INTUBATION; COMPLICATIONS AB Objective: The objective of our study is to describe the technique of distal endotracheal tube (ETT) positioning for avoiding cuff rupture and validate the technique in a virtual tracheostomy model. Methods: A prospective nonrandomized case series of 129 patients who had undergone tracheostomy using the senior author's technique were evaluated. Primary outcome was ETT cuff rupture. One hundred normal patient computed tomography (CT) scans were used to generate a virtual tracheostonny model, and the probability of cuff rupture, among other values, was obtained. Results: One hundred twenty-three of 129 patients underwent tracheostomy without cuff rupture when the distal tip of the ETT was placed just proximal to the carina. After analysis of 100 3-dimensional CT scans, the average distance from the tracheotomy to the superior aspect of the cuff was 54.6 mm in men and 39.87 mm in women when a 6.5-size ETT was used, and 44.8 mm in men and 30.07 mm in women when a 7.5-size ETT was used. Virtual tracheotomy between the second and third tracheal rings resulted in no probability of inadvertent ETT cuff rupture. Conclusion: Distal ETT positioning during tracheostomy should be considered for avoiding inadvertent ETT cuff rupture. C1 [Sood, Amit; Joshi, Arjun S.] George Washington Univ, Div Otolaryngol Head & Neck Surg, Washington, DC 20006 USA. [Taheri, M. Reza] George Washington Univ, Dept Diagnost Radiol, Washington, DC 20006 USA. RP Joshi, AS (reprint author), George Washington Univ, Div Otolaryngol Head & Neck Surg, Dept Diagnost Radiol, 2021 K St NW,Suite 206, Washington, DC 20006 USA. EM ajoshi@mfa.gwu.edu CR Bradley PJ., 1997, SCOTT BROWNS OTOLARY Connor CW, 2011, ANESTH ANALG, V112, P84, DOI 10.1213/ANE.0b013e31820098d6 Conrardy PA, 1976, CRITICAL CARE MED, V4, P7, DOI 10.1097/00003246-197601000-00002 Das P, 2012, LARYNGOSCOPE, V122, P30, DOI 10.1002/lary.22453 Epstein Scott K, 2005, Respir Care, V50, P542 Gillies M, 2008, BRIT J ANAESTH, V101, P129, DOI 10.1093/bja/aen158 Halum SL, 2012, LARYNGOSCOPE, V122, P38, DOI 10.1002/lary.22364 Kim WH, 2011, BRIT J ANAESTH, V106, P743, DOI 10.1093/bja/aer024 Shah RK, 2012, LARYNGOSCOPE, V122, P25, DOI 10.1002/lary.21907 NR 9 TC 0 Z9 0 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD SEP PY 2014 VL 123 IS 9 BP 654 EP 657 DI 10.1177/0003489414528866 PG 4 WC Otorhinolaryngology SC Otorhinolaryngology GA AN4TH UT WOS:000340580900010 PM 24707013 ER PT J AU Tokita, J Kung, R Parekh, K Hoffman, H AF Tokita, Joshua Kung, Raymond Parekh, Kalpaj Hoffman, Henry TI Resection of the Innominate Artery to Prevent an Impending Tracheoinnominate Fistula and to Permit Tracheotomy in a Patient With Subglottic Stenosis and High-riding Innominate SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE subglottic stenosis; tracheoinnominate artery fistula; tracheotomy AB Objective: This study aimed to determine the long-term viability of innominate artery resection and tracheotomy for a patient at high risk of developing a tracheoinnominate fistula (TIF) in the setting of subglottic stenosis and a high-riding innominate artery. Methods: Chart review with 2-year follow-up. Results: A 45-year-old diabetic man with obstructive sleep apnea and multiple admissions for coma and delirium tremens associated with alcohol abuse developed subglottic stenosis. He was found to have a palpable supraclavicular pulse during preoperative examination for a tracheotomy. Computed tomography examination revealed a high-riding innominate artery at the level of stenosis along with granulation tissue and disruption of the cartilaginous trachea, suggesting a high risk of impending TIF. The patient underwent a sternotomy-approach resection of the innominate artery with closure of the distal stump with a sternohyoid muscle flap. Intraoperatively, a plane of adhesions between the posterior innominate artery and trachea was dissected. The anterior tracheal wall appeared calcified but without evidence of erosion of either the trachea or the artery. Six weeks later, a tracheotomy was performed. Follow-up at 27 months did not identify complications from the innominate artery resection. Conclusion: Resection of the innominate artery is an option for some patients either to address the warning signs of TIF or to permit a tracheotomy to be performed in the presence of a high innominate artery. C1 [Tokita, Joshua; Kung, Raymond; Hoffman, Henry] Univ Iowa Hosp & Clin, Dept Otolaryngol Head & Neck Surg, Iowa City, IA 52242 USA. [Parekh, Kalpaj] Univ Iowa Hosp & Clin, Dept Cardiothorac Surg, Iowa City, IA 52242 USA. RP Hoffman, H (reprint author), Univ Iowa Hosp & Clin, Dept Otolaryngol Head & Neck Surg, 200 Hawkins Dr,21264 PFP, Iowa City, IA 52242 USA. EM henry-hoffman@uiowa.edu CR Allan James S, 2003, Chest Surg Clin N Am, V13, P331, DOI 10.1016/S1052-3359(03)00006-1 COLE RR, 1988, LARYNGOSCOPE, V98, P131 COOPER JD, 1969, ANN SURG, V169, P334, DOI 10.1097/00000658-196903000-00007 GRILLO HC, 1995, J THORAC CARDIOV SUR, V109, P486, DOI 10.1016/S0022-5223(95)70279-2 Grillo HC, 1995, J THORAC CARDIOVASC, V109, P492 Hisamatsu C, 2012, PEDIATR SURG INT, V28, P877, DOI 10.1007/s00383-012-3138-y Hoffman HT, IOWA HEAD NECK PROTO Iodice F, 2007, EUR J CARDIO-THORAC, V31, P747, DOI 10.1016/j.ejcts.2006.12.028 Maynar M, 1993, J Vasc Interv Radiol, V4, P289, DOI 10.1016/S1051-0443(93)71858-8 Obatake M, 2011, CASE REPORT MED, V2011 Takasaki K, 2005, AURIS NASUS LARYNX, V32, P195, DOI 10.1016/j.anl.2004.11.002 Wright C D, 1996, Chest Surg Clin N Am, V6, P865 NR 12 TC 0 Z9 0 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD SEP PY 2014 VL 123 IS 9 BP 658 EP 661 DI 10.1177/0003489414528670 PG 4 WC Otorhinolaryngology SC Otorhinolaryngology GA AN4TH UT WOS:000340580900011 PM 24824081 ER PT J AU Owen, JH Hauff, SJ Tang, AL Graham, MP Czerwinski, MJ Kaddoura, M Papagerakis, S Bradford, CR Carey, TE Prince, MEP AF Owen, John H. Hauff, Samantha J. Tang, Alice L. Graham, Martin P. Czerwinski, Michael J. Kaddoura, Marcella Papagerakis, Silvana Bradford, Carol R. Carey, Thomas E. Prince, Mark E. P. TI UM-SCC-103: A Unique Tongue Cancer Cell Line That Recapitulates the Tumorigenic Stem Cell Population of the Primary Tumor SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE squamous cell carcinoma; cell line; tumorigenic; cancer stem cell; CD44; aldehyde dehydrogenase ID CARCINOMA; HEAD; CD44; METASTASIS; MODELS; IDENTIFICATION; EXPRESSION; ESTABLISHMENT; MECHANISMS; RATIONALE AB Objective: A new head and neck cancer cell line was developed from a highly aggressive HNSCC of the oral cavity diagnosed in a 26-year-old pregnant woman. Methods: Cells from the primary tumor were passaged in culture and genotyped as a unique cell line. The resultant cell line was assessed for its ability to replicate the primary tumor. Results: The primary tumor and cell line contained 19.03% and 19.62% CD44(high) cells, respectively. CD44(high) cancer stem cells from UM-SCC-103 formed tumors after flank injections in mice that reconstituted the heterogeneity of the primary tumor.. CD44 staining and histology in the primary tumor and tumors grown in vivo from the cell line were similar. CD44(high) cells from the primary tumor resulted in lung colony formation in 2 out of 2 tail vein injections in mice, whereas CD44(low) cells did not. Similarly, CD44(high) cells from UM-SCC-103 formed lung tumors in 2 out of 4 mice, whereas CD44(low) cells did not. Conclusion: The similarity in marker expression and tumorigenic behavior between the primary tumor and the resulting cell line strongly suggests that the cell line resembles the primary tumor that it was derived from and provides an important new research tool for the study of head and neck carcinomas in young patients. C1 [Owen, John H.; Graham, Martin P.; Czerwinski, Michael J.; Papagerakis, Silvana; Bradford, Carol R.; Carey, Thomas E.; Prince, Mark E. P.] Univ Michigan, Dept Otolaryngol Head & Neck Surg, Ann Arbor, MI 48109 USA. [Hauff, Samantha J.] Univ Calif San Diego, Div Otolaryngol Head & Neck Surg, San Diego, CA 92103 USA. [Tang, Alice L.] Univ Cincinnati, Dept Otolaryngol Head & Neck Surg, Cincinnati, OH USA. [Kaddoura, Marcella] Wayne State Univ, Sch Med, Detroit, MI USA. RP Prince, MEP (reprint author), Univ Michigan, Dept Otolaryngol Head & Neck Surg, 1500 E Med Ctr Dr,1903 Taubman Ctr,SPC 5312, Ann Arbor, MI 48109 USA. EM mepp@umich.edu CR Al-Hajj M, 2003, P NATL ACAD SCI USA, V100, P3983, DOI 10.1073/pnas.0530291100 Al-Hajj M, 2004, CURR OPIN GENET DEV, V14, P43, DOI 10.1016/j.gde.2003.11.007 Atabo A, 2008, ORAL ONCOL, V44, P236, DOI 10.1016/j.oratoncology.2007.02.003 Biddle A, 2011, CANCER RES, V71, P5317, DOI 10.1158/0008-5472.CAN-11-1059 Brabletz T, 2005, CELLS TISSUES ORGANS, V179, P56, DOI 10.1159/000084509 Bradley Patrick J, 2004, Curr Opin Otolaryngol Head Neck Surg, V12, P76, DOI 10.1097/00020840-200404000-00004 Clay MR, 2010, HEAD NECK-J SCI SPEC, V32, P1195, DOI 10.1002/hed.21315 Dancik GM, 2011, CANCER RES, V71, P7398, DOI 10.1158/0008-5472.CAN-11-2427 Davis SJ, 2010, ARCH OTOLARYNGOL, V136, P1260, DOI 10.1001/archoto.2010.219 Eliassen AM, 2013, HEAD NECK-J SCI SPEC, V35, P335, DOI 10.1002/hed.22973 Elkin M, 2001, CURR PROTOC CELL BIO Ertel A, 2006, MOL CANCER, V5, DOI 10.1186/1476-4598-5-55 FIDLER IJ, 1986, CANCER METAST REV, V5, P29, DOI 10.1007/BF00049529 Guo W, 2006, PEDIATR RES, V59, P59 Hu J, 2006, FASEB J, V20, P1892, DOI 10.1096/fj.06-5930fje Hughes P, 2007, BIOTECHNIQUES, V43, P575, DOI 10.2144/000112598 Indinnimeo M, 2003, ONCOL REP, V10, P1875 Iwasaki A, 1997, ONCOL REP, V4, P815 Jordan CT, 2006, NEW ENGL J MED, V355, P1253, DOI 10.1056/NEJMra061808 Kerbel RS, 2003, CANCER BIOL THER, V2, pS134 Kim SY, 1997, ACTA OTO-LARYNGOL, V117, P775, DOI 10.3109/00016489709113477 Lessard J, 2003, NATURE, V423, P257 Lin CJ, 2007, HEAD NECK-J SCI SPEC, V29, P163, DOI 10.1002/hed.20478 Marhaba R, 2004, J MOL HISTOL, V35, P211 Nogowa M, 2005, CANC LETT, V217, P243 Prince ME, 2007, P NATL ACAD SCI USA, V104, P973, DOI 10.1073/pnas.0610117104 Reya T, 2001, NATURE, V414, P105, DOI 10.1038/35102167 Richmond A, 2008, DIS MODEL MECH, V1, P78, DOI 10.1242/dmm.000976 SEITER S, 1993, J EXP MED, V177, P443, DOI 10.1084/jem.177.2.443 Sheridan C, 2006, BREAST CANCER RES, V8, DOI 10.1186/bcr1610 Shiratori H, 2001, CANCER LETT, V170, P177, DOI 10.1016/S0304-3835(01)00587-0 Soltysova A, 2005, NEOPLASMA, V52, P435 Sugahara KN, 2006, J BIOL CHEM, V281, P5861, DOI 10.1074/jbc.M506740200 White JS, 2007, ORAL ONCOL, V43, P701, DOI 10.1016/j.oraloncotogy.2006.09.001 Wong RJ, 2009, AM COLL SURG, V193, P12 Zhou JB, 2008, CELL CYCLE, V7, P1360, DOI 10.4161/cc.7.10.5953 NR 36 TC 0 Z9 0 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD SEP PY 2014 VL 123 IS 9 BP 662 EP 672 DI 10.1177/0003489414531910 PG 11 WC Otorhinolaryngology SC Otorhinolaryngology GA AN4TH UT WOS:000340580900012 PM 24816422 ER PT J AU Bayazit, YA Kosaner, J Cinar, BC Atac, A Tutar, H Gunduz, B Altinyay, S Gokdoga, C Ant, A Ozdek, A Goksu, N AF Bayazit, Yildirim A. Kosaner, Julie Cinar, Betul Cicek Atac, Ahmet Tutar, Hakan Gunduz, Bulent Altinyay, Senay Gokdoga, Cagil Ant, Ayca Ozdek, Ali Goksu, Nebil TI Methods and Preliminary Outcomes of Pediatric Auditory Brainstem Implantation SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE auditory brainstem implant; prelingual hearing loss; inner ear malformation ID COCHLEAR IMPLANTS; DEAF-CHILDREN; PERFORMANCE; HEARING; QUESTIONNAIRE; ADULTS; NERVE AB Objective: The objective was to provide information about methods used and preliminary outcomes for pediatric ABI (auditory brainstem implant). Study Design: An analysis of outcome was performed in children who received an ABI. Methods: Twelve children received a MED-EL ABI system. Progress in audition and language was monitored through parental reports, questionnaires, profiles, and closed-set tests. Results: The median number of active electrodes was 9 of 12. Seven of 12 users consistently respond to sound, and 5 of 12 do not. Highest performers can recognize words in small sets and have begun to use some words. Conclusion: Auditory brainstem implants appear to be beneficial for some pediatric patients who cannot benefit from traditional cochlear implant surgery. Benefits in the short term can be recognition of environmental sounds, recognition of some words and very commonly used phrases, and the beginning use of words. Although some of our ABI users demonstrate no response to sound, they do want to wear their sound processors all waking hours. The cause of lack of response may be related to the second intervention, which might have led to displacement of the electrode array, or presence of additional handicaps or syndromes. However, the results are less than optimal. The relatively short postoperative follow-up duration is a considered weakness of this study. C1 [Bayazit, Yildirim A.] Medipol Univ, Fac Med, Dept Otolaryngol, Istanbul, Turkey. [Kosaner, Julie; Cinar, Betul Cicek] Meders Hearing & Speech Ctr, Ankara, Turkey. [Kosaner, Julie; Cinar, Betul Cicek] Meders Hearing & Speech Ctr, Istanbul, Turkey. [Atac, Ahmet] Istanbul Univ, Cerrhapasa Med Fac, Audiol Unit, Istanbul, Turkey. [Tutar, Hakan; Ant, Ayca; Goksu, Nebil] Gazi Univ, Fac Med, Dept Otolaryngol, Ankara, Turkey. [Gunduz, Bulent; Altinyay, Senay; Gokdoga, Cagil] Gazi Univ, Fac Med, Audiol Unit, Ankara, Turkey. [Ozdek, Ali] Yildirim Bayazit Diskapi Educ & Res Hosp, Dept Otolaryngol, Minist Hlth, Ankara, Turkey. RP Bayazit, YA (reprint author), Medipol Univ, Fac Med, Dept Otolaryngol, Istanbul, Turkey. EM bayazity@yahoo.com CR Bayazit YA, 2011, ORL-J OTO-RHIN-LARYN, V73, P72, DOI 10.1159/000323438 Behr R, 2007, SKULL BASE-INTERD AP, V17, P91, DOI 10.1055/s-2006-950390 BRACKMANN DE, 1993, OTOLARYNG HEAD NECK, V108, P624 Buchman CA, 2011, LARYNGOSCOPE, V121, P1979, DOI 10.1002/lary.22032 Colletti L, 2008, LARYNGOSCOPE, V118, P1443, DOI [10.1097/MLG.0b013e318173a011, 10.1097/MLG.0b03e318173a011] Colletti V, 2010, OTOL NEUROTOL, V31, P558, DOI 10.1097/MAO.0b013e3181db7055 Colletti V, 2005, OTOLARYNG HEAD NECK, V133, P126, DOI 10.1016/j.otohns.2005.03.022 Colletti L, 2011, INT J PEDIATR OTORHI, V75, P504, DOI 10.1016/j.ijporl.2011.01.005 Coninx F, 2009, INT J PEDIATR OTORHI, V73, P1761, DOI 10.1016/j.ijporl.2009.09.036 Connor CM, 2006, EAR HEARING, V27, P628, DOI 10.1097/01.aud.0000240640.59205.42 Eisenberg LS, 2008, OTOL NEUROTOL, V29, P251 Eisenberg LS, 2012, J AM ACAD AUDIOL, V23, P412, DOI 10.3766/jaaa.23.6.4 Goffi-Gomez MVS, 2012, INT J PEDIATR OTORHI, V76, P257, DOI 10.1016/j.ijporl.2011.11.016 HITSELBERGER WE, 1984, OTOLARYNG HEAD NECK, V92, P52 Kosaner J, 2013, INT J PEDIATR OTORHI, V77, P1359, DOI 10.1016/j.ijporl.2013.05.036 Lenarz M, 2002, OTOL NEUROTOL, V23, P694, DOI 10.1097/00129492-200209000-00015 Lenarz T, 2001, OTOL NEUROTOL, V22, P823, DOI 10.1097/00129492-200111000-00019 May-Mederake B, 2010, INT J PEDIATR OTORHI, V74, P1149, DOI 10.1016/j.ijporl.2010.07.003 Nevison B, 2002, EAR HEARING, V23, P170, DOI 10.1097/00003446-200206000-00002 Otto SR, 2002, J NEUROSURG, V96, P1063, DOI 10.3171/jns.2002.96.6.1063 Sennaroglu L, 2011, OTOL NEUROTOL, V32, P187, DOI 10.1097/MAO.0b013e318206fc1e Sennaroglu L, 2009, OTOL NEUROTOL, V30, P708, DOI 10.1097/MAO.0b013e3181b07d41 Young NM, 2012, INT J PEDIATR OTORHI, V76, P1442, DOI 10.1016/j.ijporl.2012.06.019 NR 23 TC 1 Z9 1 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD AUG PY 2014 VL 123 IS 8 BP 529 EP + DI 10.1177/0003489414525123 PG 8 WC Otorhinolaryngology SC Otorhinolaryngology GA AM0LV UT WOS:000339538000001 PM 24634154 ER PT J AU Dhillon, VK Hoa, M Winter, M Wilkinson, EP AF Dhillon, Vaninder K. Hoa, Michael Winter, Margaret Wilkinson, Eric P. TI Extrusion of a Cochlear Implant Positioner Through the Tympanic Membrane in a Pediatric Patient: Management of a Delayed Complication SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE cochlear implant; extruded positioner; pediatric ID ELECTRODE EXTRUSION; MENINGITIS; RISK AB Objective: This study aimed to present a case of an extruded Advanced Bionics positioner, with the goal of educating a new generation of otologic surgeons on management of the delayed complications associated with this cochlear implant model. Methods: Retrospective case report in a pediatric patient. Results: We observed the extrusion of an Advanced Bionics positioner 10 years after cochlear implantation. Conclusion: Awareness of the Advanced Bionics positioner as a component of certain historical models of cochlear implants is important as the delayed complications associated with this model may still be encountered. Management of an extruded positioner should include precautions against infectious complications, repair of the defect, and assessment of the patient's performance with the cochlear implant. C1 [Dhillon, Vaninder K.] Univ So Calif, Sch Med, Dept Otolaryngol Head & Neck Surg, Los Angeles, CA USA. [Hoa, Michael; Wilkinson, Eric P.] House Clin, Los Angeles, CA 90057 USA. [Winter, Margaret] Univ So Calif, Ctr Childhood Commun, Los Angeles, CA USA. RP Wilkinson, EP (reprint author), House Clin, 2100 West 3rd St,111, Los Angeles, CA 90057 USA. EM ewilkinson@hei.org CR Bassim MK, 2007, OTOLARYNG HEAD NECK, V137, P680, DOI 10.1016/j.otohns.2007.04.028 Lalwani AK, 2011, OTOL NEUROTOL, V32, P1082, DOI 10.1097/MAO.0b013e31822a1ea1 Reefhuis J, 2003, NEW ENGL J MED, V349, P435, DOI 10.1056/NEJMoa031101 Tahery J, 2004, J LARYNGOL OTOL, V118, P804 Tarkan O, 2013, INT J PEDIATR OTORHI, V77, P473, DOI 10.1016/j.ijporl.2012.12.009 NR 5 TC 0 Z9 0 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD AUG PY 2014 VL 123 IS 8 BP 537 EP 540 DI 10.1177/0003489414525345 PG 4 WC Otorhinolaryngology SC Otorhinolaryngology GA AM0LV UT WOS:000339538000002 PM 24634149 ER PT J AU Massoth, LJ Digoy, GP AF Massoth, Landon J. Digoy, G. Paul TI Flexible Carbon Dioxide Laser-Assisted Endoscopic Marsupialization and Ablation of a Laryngeal Saccular Cyst in a Neonate SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE congenital saccular cyst; endoscopic approach; laser ID MANAGEMENT; LARYNGOCELES; INFANTS AB Objective: To report the occurrence of a neonate with a lateral saccular cyst that was successfully managed by flexible, carbon dioxide laser-assisted endoscopic marsupialization and ablation. Case Summary: A full-term, 14-day-old girl presented to the clinic for progressively worsening stridor since birth. On fiber optic laryngoscopy, she was found to have a large, right saccular cyst obstructing the laryngeal inlet. The patient was admitted and underwent microlaryngeal endoscopic CO2 laser marsupialization and ablation of the saccular cyst. She was observed overnight and was discharged without complication the next day. At that time, stridor was no longer present and she remained symptom free at both her 2-week and 3-month follow-up. Discussion: The congenital saccular cyst is a rare, abnormal dilation of the laryngeal saccule that is known to be a cause of airway obstruction. A variety of contrasting treatment strategies for laryngeal saccular cysts in children have been reported in the literature. Determining the definitive treatment modality thus remains a challenge that is compounded further by the rarity of the lesion. Conclusion: We introduce a new surgical technique that employs a 30-degree angled telescope with a flexible laser fiber system that provides excellent visualization of saccular cysts, in particular, lateral lesions that are less visible using line-of-sight technology. C1 [Massoth, Landon J.] Univ Oklahoma, Coll Med, Med Ctr, Oklahoma City, OK 73126 USA. [Digoy, G. Paul] Univ Oklahoma, Med Ctr, Dept Otorhinolaryngol, Oklahoma City, OK 73126 USA. RP Digoy, GP (reprint author), Univ Oklahoma, Med Ctr, Dept Otorhinolaryngol, Oklahoma City, OK 73126 USA. EM paul-digoy@ouhsc.edu CR Ahmad SM, 2007, OTOLARYNG CLIN N AM, V40, P177, DOI 10.1016/j.otc.2006.10.004 BOOTH JB, 1981, ARCH OTOLARYNGOL, V107, P500 Caperton K, 2011, INT J PEDIATR OTORHI, V2011, DOI [10.1155/2011/521464, DOI 10.1155/2011/521464] CIVANTOS FJ, 1992, ARCH OTOLARYNGOL, V118, P296 Danish HMN, 1998, ARCH OTOLARYNGOL, V124, P593 Forte V, 2004, LARYNGOSCOPE, V114, P1123, DOI 10.1097/00005537-200406000-00031 Jacobson S, 2006, OTOLARYNGOL HEAD NEC, V135, P469 Kirse DJ, 2006, ARCH OTOLARYNGOL, V132, P724, DOI 10.1001/archotol.132.7.724 Malis DJ, 1998, LARYNGOSCOPE, V108, P941, DOI 10.1097/00005537-199806000-00028 MYSSIOREK D, 1989, OTOLARYNG HEAD NECK, V100, P538 Pak MW, 1996, J LARYNGOL OTOL, V110, P854 Prowse S, 2012, INT J PEDIATR OTORHI, V76, P708, DOI 10.1016/j.ijporl.2012.02.025 Shurgalin Max, 2008, Biomed Instrum Technol, V42, P318, DOI 10.2345/0899-8205(2008)42[318:ANMFMI]2.0.CO;2 WARD RF, 1995, ANN OTO RHINOL LARYN, V104, P707 NR 14 TC 0 Z9 0 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD AUG PY 2014 VL 123 IS 8 BP 541 EP 544 DI 10.1177/0003489414525343 PG 4 WC Otorhinolaryngology SC Otorhinolaryngology GA AM0LV UT WOS:000339538000003 PM 24646753 ER PT J AU Bhattacharyya, N AF Bhattacharyya, Neil TI Regional Variation and Factors Associated With Image Guidance Utilization During Endoscopic Sinus Surgery in the Ambulatory Setting SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE endoscopic sinus surgery; chronic rhinosinusitis; image guided surgery; variation in care; nasal polyposis; insurance AB Objective: Determine regional variation and factors associated with the use of image guidance (IG) during endoscopic sinus surgery (ESS) in the ambulatory surgery center setting. Methods: All cases of ESS in 2010 were extracted from the state ambulatory surgery databases for New York, North Carolina, Florida, Iowa, and California. Current Procedural Terminology codes for individual sinusotomies and IG and International Classification of Diseases codes along with insurance and regional data were analyzed to determine factors that were associated with the use of IG during ESS. Results: Among 36 646 ambulatory ESS procedures (mean age 46.0 years; 49.0% female), 6676 cases utilized IG (18.2%). Polyps were present in 27.9% of cases. North Carolina had the highest utilization rate for IG (26.0%), whereas Iowa had the lowest (12.8%). On multivariate analysis, use of IG was associated with state, insurance status, community setting, total ethmoidectomy, frontal sinusotomy, sphenoidotomy, and polyps (all P < .001), but not maxillary antrostomy (P = .197). The highest procedural odds ratio for IG use was noted for total ethmoidectomy (2.07), followed by frontal sinusotomy (1.97) and sphenoidotomy (1.26). Conclusion: Although IG is utilized in a relative minority of ESS cases, there is considerable regional variation in use. Factors other than complexity of surgery influence IG utilization as well. C1 [Bhattacharyya, Neil] Brigham & Womens Hosp, Div Otolaryngol, Boston, MA 02115 USA. RP Bhattacharyya, N (reprint author), 45 Francis St, Boston, MA 02115 USA. EM neiloy@massmed.org CR Bhattacharyya N, 2010, LARYNGOSCOPE, V120, P635, DOI 10.1002/lary.20777 Bhattacharyya N, 2011, OTOLARYNG HEAD NECK, V144, P440, DOI 10.1177/0194599810391852 Hepworth EJ, 2006, OTOLARYNG HEAD NECK, V135, P68, DOI 10.1016/j.otohns.2006.01.025 Justice JM, 2012, INT FORUM ALLERGY RH, V2, P155, DOI 10.1002/alr.20107 Kezirian EJ, 2010, OTOLARYNG HEAD NECK, V143, P441, DOI 10.1016/j.otohns.2010.05.009 Strope SA, 2009, BMC HEALTH SERV RES, V9, DOI 10.1186/1472-6963-9-121 Suskind AM, 2012, INT UROGYNECOL J, V24, P207 Virgin FW, 2010, OTOLARYNG CLIN N AM, V43, P653, DOI 10.1016/j.otc.2010.02.018 NR 8 TC 1 Z9 1 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD AUG PY 2014 VL 123 IS 8 BP 545 EP 549 DI 10.1177/0003489414525344 PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA AM0LV UT WOS:000339538000004 PM 24634150 ER PT J AU Presutti, L Alicandri-Ciufelli, M Rubini, A Gioacchini, FM Marchioni, D AF Presutti, Livio Alicandri-Ciufelli, Matteo Rubini, Alessia Gioacchini, Federico Maria Marchioni, Daniele TI Combined Lateral Microscopic/Endoscopic Approaches to Petrous Apex Lesions: Pilot Clinical Experiences SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE combined approaches; petrous apex ID ENDOSCOPIC MANAGEMENT; SURGICAL ANATOMY; DYSVENTILATION; CHOLESTEATOMA AB Background: Surgical treatment of lesions involving the temporal bone, petrous apex, or internal auditory canal is usually performed using the classical microscopic approach that necessitates wide external incisions and soft tissue dissection. At present, the main application of endoscopic surgery is in the surgical treatment of middle ear cholesteatoma, but with the natural evolution of the technique, there will be an increasing number of applications in lateral skull base surgery. Objective: This study aimed to describe the pilot clinical experiences of our institution with combined microscopic/endoscopic-assisted approaches to the lateral skull base. Methods: A retrospective chart review was performed on patients undergoing an operation between July 2005 and September 2011 for lateral skull base pathology using the endoscope-assisted technique. Results: Nine patients (7 female, 2 male; mean age = 57.4 years) were reviewed and included in the present study. In all cases, the petrous apex lesion of each. patient was unilateral: 6 cases had cholesteatoma of the petrous bone; 2 cases had cholesterinic granuloma of the petrous apex; and 1 case had a low-grade chondrosarcoma of the petrous apex. Overall, after a mean follow-up of 30.7 months, no residual disease has been found in our series up to the present time in the cholesteatoma group. In the cholesterinic granuloma group, only a partial success was obtained in the patient who underwent the infracochlear approach, since the most medial part of the pathology was not accessed and still persisted at neuroradiologic examinations made postoperatively. Conclusion: In our case series, lateral combined microscopic/endoscopic procedures have proved to be effective in the treatment of petrous apex lesions, allowing less destructive approaches compared to exclusive microscopic procedures. C1 [Presutti, Livio; Alicandri-Ciufelli, Matteo; Rubini, Alessia; Gioacchini, Federico Maria; Marchioni, Daniele] Univ Hosp Modena, Dept Otolaryngol Head & Neck Surg, I-41100 Modena, Italy. RP Gioacchini, FM (reprint author), Univ Hosp Modena, Dept Otolaryngol Head & Neck Surg, Via Pozzo 71, I-41100 Modena, Italy. EM giox83@hotmail.com CR Alicandri-Ciufelli M, 2012, J NEURORADIOLOGY, V39, P149, DOI 10.1016/j.neurad.2011.05.004 Marchioni D, 2013, EUR ARCH OTO-RHINO-L, V270, P1267, DOI 10.1007/s00405-012-2137-x Marchioni D, 2010, LARYNGOSCOPE, V120, P1880, DOI 10.1002/lary.20995 Marchioni D, 2011, EUR ARCH OTO-RHINO-L, V268, P1557, DOI 10.1007/s00405-011-1533-y Marchioni D, 2010, LARYNGOSCOPE, V120, P1028, DOI 10.1002/lary.20841 Marchioni D, 2011, MED HYPOTHESES, V77, P116, DOI 10.1016/j.mehy.2011.03.041 Marchioni D, 2011, LARYNGOSCOPE, V121, P1565, DOI 10.1002/lary.21819 Presutti L, 2008, J OTOLARYNGOL-HEAD N, V37, P481, DOI 10.2310/7070.2008.0092 Tarabichi M, 2004, LARYNGOSCOPE, V114, P1157, DOI 10.1097/00005537-200407000-00005 NR 9 TC 0 Z9 0 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD AUG PY 2014 VL 123 IS 8 BP 550 EP 559 DI 10.1177/0003489414525342 PG 10 WC Otorhinolaryngology SC Otorhinolaryngology GA AM0LV UT WOS:000339538000005 PM 24634157 ER PT J AU Ayala, MA Morawiecki, PA Yencha, MW AF Ayala, Marco A. Morawiecki, Peter A. Yencha, Myron W. TI Hemangioblastoma Arising From the Submandibular Gland SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE hemangioblastoma; von Hippel-Lindau disease; salivary gland neoplasm AB Objective: The objective was to document and describe the clinical features of a hemangioblastoma arising from a submandibular gland. Methods: A case report of a 63-year-old man with a right submandibular gland hemangioblastoma. Results: Submandibular gland excision and histological examination revealed a hemangioblastoma. Subsequent evaluation with imaging studies found no association with von Hippel-Lindau disease. Conclusion: We report the first presentation of a hemangioblastoma arising in a salivary gland. Further evaluation of patients with a hemangioblastoma is recommended given the neoplasms' association with von Hippel-Lindau disease. C1 [Ayala, Marco A.; Yencha, Myron W.] Captain James A Lovell Fed Hlth Care Ctr, Dept Otolaryngol Head & Neck Surg, N Chicago, IL 60064 USA. [Morawiecki, Peter A.] Captain James A Lovell Fed Hlth Care Ctr, N Chicago, IL 60064 USA. RP Ayala, MA (reprint author), Captain James A Lovell Fed Hlth Care Ctr, Dept Otolaryngol Head & Neck Surg, 3001 Green Bay Rd, N Chicago, IL 60064 USA. EM Marco.ayala@va.gov CR Deb P, 2012, ENDOCR PATHOL, V23, P187, DOI 10.1007/s12022-012-9207-x Kleihues P, 2000, TUMOURS NERVOUS SYST, P223 Miller DJ, 2000, J NEURO-ONCOL, V47, P253, DOI 10.1023/A:1006403500801 Nonaka D, 2007, AM J SURG PATHOL, V31, P1545 Papaioannou G, 2009, CANCER IMAGING, V9, P1, DOI 10.1102/1470-7330.2009.0001 Sora S, 2001, ACTA NEUROCHIR, V143, P893, DOI 10.1007/s007010170019 Thompson LD, 1997, MEDICINE, V76, P381 NR 7 TC 0 Z9 0 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD AUG PY 2014 VL 123 IS 8 BP 560 EP 563 DI 10.1177/0003489414525341 PG 4 WC Otorhinolaryngology SC Otorhinolaryngology GA AM0LV UT WOS:000339538000006 PM 24623019 ER PT J AU Brandt, MG Rotenberg, BW Moore, CC Bornbaum, CC Dzioba, A Glicksman, JT Doyle, PC AF Brandt, Michael G. Rotenberg, Brian W. Moore, Corey C. Bornbaum, Catherine C. Dzioba, Agnieszka Glicksman, Jordan T. Doyle, Philip C. TI Impact of Nasal Surgery on Speech Resonance SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE nasality; resonance; acoustics; nasal surgery; endoscopic sinus surgery; rhinoplasty ID ENDOSCOPIC SINUS SURGERY; VOICE; SPEAKERS; QUALITY AB Objectives: The nose and paranasal sinuses contribute to speech resonance and changes to these structures may alter speech nasality. This change may influence one's vocational and social functioning and quality of life. Our investigation explored objective and subjective changes in nasality following nasal surgery in a prospective and longitudinal fashion. Methods: Recordings of sustained vowel and sentence stimuli and voice-related quality of life measurements were obtained preoperatively and at 2, 4, 8, and 24 weeks postoperatively from individuals undergoing nasal and/or sinus surgery. Objective measures of fundamental frequency, jitter, shimmer, and harmonic to noise ratio (HNR) were determined. Pre- and postoperative speech samples were assessed by 15 nave listeners. Results: In all, 15 subjects completed the study. Neither speakers nor listeners perceived a subjective change in nasality following surgery. No statistically significant change in microacoustic measures were identified. Although nasal sentences did not reveal differences for 3 microacoustic measures, a difference in HNR was identified. Conclusions: Patients undergoing nasal surgery did not exhibit subjective changes in resonance postoperatively. Aside from a difference in HNR for the nasal sentence, objective microacoustics remained unchanged. These results demonstrate the stability of oranasal resonance despite nasal surgery and provide valuable data for patient informed decision-making. C1 [Brandt, Michael G.] Univ Toronto, Fac Med, Dept Otolaryngol Head & Neck Surg, Div Facial Plast & Reconstruct Surg, Toronto, ON, Canada. [Brandt, Michael G.; Rotenberg, Brian W.; Moore, Corey C.; Doyle, Philip C.] Univ Western Ontario, Fac Hlth Sci, London, ON, Canada. [Bornbaum, Catherine C.; Dzioba, Agnieszka; Glicksman, Jordan T.; Doyle, Philip C.] Univ Western Ontario, Schulich Sch Med & Dent, Dept Otolaryngol Head & Neck Surg, London, ON, Canada. RP Rotenberg, BW (reprint author), St Josephs Healthcare Ctr, 268 Grosvenor St, London, ON N6A 4V2, Canada. EM Brian.Rotenberg@sjhc.london.on.ca FU Physician Services Incorporated (PSI) Foundation Grant FX The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This study was funded by a Physician Services Incorporated (PSI) Foundation Grant. CR Behrman A, 2002, OTOLARYNG HEAD NECK, V127, P36, DOI 10.1067/mhn.2002.126589 BRITTO AI, 1990, J SPEECH HEAR DISORD, V55, P476 Chen MY, 1997, ARCH OTOLARYNGOL, V123, P845 Eadie TL, 2005, J VOICE, V19, P1, DOI 10.1016/j.jvoice.2004.02.002 Eadie TL, 2002, J ACOUST SOC AM, V112, P3014, DOI 10.1121/1.1518983 Fairbanks G, VOICE ARTICULATION D Hogikyan ND, 1999, J VOICE, V13, P557, DOI 10.1016/S0892-1997(99)80010-1 Hong KH, 1997, OTOLARYNG HEAD NECK, V117, P343, DOI 10.1016/S0194-5998(97)70124-4 Hosemann W, 1998, EUR ARCH OTO-RHINO-L, V255, P499, DOI 10.1007/s004050050107 Jacobson BH, 1997, AM J SPEECH-LANG PAT, V6, P66 Kummer AW, 2006, ASHA LEADER Lund Valerie J., 1993, Rhinology (Utrecht), V31, P183 Soneghet R, 2002, J VOICE, V16, P392, DOI 10.1016/S0892-1997(02)00110-8 Stevens S. S., 1975, PSYCHOPHYSICS INTRO NR 14 TC 0 Z9 0 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD AUG PY 2014 VL 123 IS 8 BP 564 EP 570 DI 10.1177/0003489414525595 PG 7 WC Otorhinolaryngology SC Otorhinolaryngology GA AM0LV UT WOS:000339538000007 PM 24646754 ER PT J AU Suzuki, H Ikezaki, S Imazato, K Koizumi, H Ohbuchi, T Hohchi, N Hashida, K AF Suzuki, Hideaki Ikezaki, Shoji Imazato, Kei Koizumi, Hiroki Ohbuchi, Toyoaki Hohchi, Nobusuke Hashida, Koichi TI Partial Mastoid Obliteration Combined With Soft-wall Reconstruction for Middle Ear Cholesteatoma SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE middle ear cholesteatoma; canal-wall-down tympanoplasty; soft-wall reconstruction; partial mastoid obliteration ID CANAL WALL; RESIDUAL CHOLESTEATOMA; POSTOPERATIVE AERATION; FOLLOW-UP; TYMPANOPLASTY; SURGERY; HEARING; TYMPANOMASTOIDECTOMY; MASTOIDECTOMIES; CAVITY AB Objectives: The objective was to analyze the surgical outcomes of tympanoplasty with partial mastoid obliteration and soft-wall reconstruction for middle ear cholesteatoma. Methods: Sixty-nine patients (73 ears) with fresh middle ear cholesteatomas, 42 men and 27 women aged 6 to 89 years, were retrospectively analyzed. The cholesteatomas were the pars flaccida and tensa types in 59 and 12 ears, respectively. The patients underwent canal-wall-down tympanoplasty with partial mastoid obliteration and soft-wall reconstruction. Follow-up computed tomography was performed 6 to 12 months after surgery. Hearing outcomes were evaluated by the arithmetic mean of the hearing levels at 500, 1000, and 2000 Hz. Results: Residual cholesteatoma occurred in 7 ears (9.6%) and recurrent cholesteatoma in 1 ear (1.4%). No cavity problem was seen. Primary evaluation of postoperative hearing was performed 6 to 12 months after ossiculoplasy. Of the 50 ears with available audiogram in this period, the postoperative air-bone gaps were <= 15 dB and <= 20 dB in 27 (54.0%) and 37 (74.0%) ears, respectively. The postoperative hearing level was within 30 dB in 22 ears (44.0%). The hearing gain was >= 15 dB in 24 ears (48.0%). Conclusions: The surgical outcomes of tympanoplasty with partial mastoid obliteration and soft-wall reconstruction for middle ear cholesteatoma were satisfactory with a low incidence of cholesteatoma recidivism and tolerable postoperative hearing without cavity problems. C1 [Suzuki, Hideaki; Ikezaki, Shoji; Koizumi, Hiroki; Ohbuchi, Toyoaki; Hohchi, Nobusuke; Hashida, Koichi] Univ Occupat & Environm Hlth, Sch Med, Dept Otorhinolaryngol Head & Neck Surg, Kitakyushu, Fukuoka 8078555, Japan. RP Suzuki, H (reprint author), Univ Occupat & Environm Hlth, Sch Med, Dept Otorhinolaryngol Head & Neck Surg, Yahatanishi Ku, 1-1 Iseigaoka, Kitakyushu, Fukuoka 8078555, Japan. EM suzuhyde@med.uoeh-u.ac.jp CR BENNETT RJ, 1981, J LARYNGOL OTOL, V95, P1 de Zinis LOR, 2010, ANN OTO RHINOL LARYN, V119, P304 Gaillardin L, 2012, EUR ANN OTORHINOLARY, V129, P136, DOI 10.1016/j.anorl.2011.01.009 Gantz BJ, 2005, LARYNGOSCOPE, V115, P1734, DOI 10.1097/01.MLG.0000187572.99335.cc Gopalakrishnan S, 2001, J LARYNGOL OTOL, V115, P967 Haginomori SI, 2008, ARCH OTOLARYNGOL, V134, P652, DOI 10.1001/archotol.134.6.652 Haginomori SI, 2009, OTOL NEUROTOL, V30, P478, DOI 10.1097/MAO.0b013e31819e634a Hosoi H, 1998, J LARYNGOL OTOL, V112, P31 Hosoi Hiroshi, 1994, Auris Nasus Larynx, V21, P69 Kakigi Akinobu, 2010, ORL J Otorhinolaryngol Relat Spec, V71 Suppl 1, P71, DOI 10.1159/000265124 Kawase T, 2007, ACTA OTO-LARYNGOL, V127, P1132, DOI 10.1080/00016480600818112 Kim CW, 2011, AURIS NASUS LARYNX, V39, P557 Lee WS, 2009, ACTA OTO-LARYNGOL, V129, P955, DOI 10.1080/00016480802510178 Roden D, 1996, J OTOLARYNGOL, V25, P178 Shinnabe A, 2011, OTOL NEUROTOL, V32, P1230, DOI 10.1097/MAO.0b013e31822f0b88 SMITH PG, 1986, OTOLARYNG HEAD NECK, V94, P355 Stankovic MD, 2008, OTOL NEUROTOL, V29, P933, DOI 10.1097/MAO.0b013e31818201af Takahashi H, 2000, AM J OTOL, V21, P28, DOI 10.1016/S0196-0709(00)80108-8 Takahashi H, 2007, EUR ARCH OTO-RHINO-L, V264, P867, DOI 10.1007/s00405-007-0273-5 Tomlin J, 2013, AUDIOL NEURO-OTOL, V18, P135, DOI 10.1159/000346140 TOS M, 1989, Auris Nasus Larynx, V16, P61 Uzun C, 2007, INT J PEDIATR OTORHI, V71, P851, DOI 10.1016/j.ijporl.2007.02.004 Walker PC, 2014, OTOL NEUROTOL, V35, pE24, DOI 10.1097/MAO.0b013e3182a446da Weber PC, 1998, AM J OTOLARYNG, V19, P178, DOI 10.1016/S0196-0709(98)90085-0 Wilson KF, 2013, LARYNGOSCOPE, V123, P3168, DOI 10.1002/lary.24202 Wilson KF, 2013, OTOLARYNG HEAD NECK, V149, P292, DOI 10.1177/0194599813489521 Yung MW, 2001, J LARYNGOL OTOL, V115, P958 NR 27 TC 0 Z9 0 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD AUG PY 2014 VL 123 IS 8 BP 571 EP 575 DI 10.1177/0003489414525335 PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA AM0LV UT WOS:000339538000008 PM 24634153 ER PT J AU Gerry, D Fritsch, VA Lentsch, EJ AF Gerry, Daniel Fritsch, Valerie A. Lentsch, Eric J. TI Spindle Cell Carcinoma of the Upper Aerodigestive Tract: An Analysis of 341 Cases With Comparison to Conventional Squamous Cell Carcinoma SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE sarcomatoid carcinoma; spindle cell carcinoma; carcinosarcoma; head and neck; SEER database ID SARCOMATOID CARCINOMAS; HEAD; NECK AB Objectives: We sought to better characterize spindle cell carcinoma (SpCC) of the upper aerodigestive tract, a rare and aggressive variant, through comparison of a large cohort of head and neck SpCCs against a cohort of conventional head and neck squamous cell carcinoma (SCC) patients. Methods: We compared epidemiologic and clinicopathologic characteristics of 341 SpCCs with 67 882 SCCs of the head and neck, drawing data from the SEER national database. We also compared disease-specific survivals (DSS) for SpCC and SCC based on tumor site and mode of treatment. Results: SpCCs were predominantly laryngeal (46.4%, P < .001) and were more likely to be high grade (P > .001). SpCCs were also more likely than SCCs to present at an early stage (P < .001 to P < .05). Rates of distant metastasis were similar between the tumor types. DSS was similar between SpCCs and SCCs, although site-specific survival rates were higher for SpCCs of the larynx (P = .017) and lower for those of the oral cavity (P = .008). Conclusion: SpCC of the head and neck is more likely than SCC to present at an early stage, with fewer nodal metastases. Survival rates appear to depend on anatomic site as well. C1 [Gerry, Daniel] Georgia Regents Univ, Augusta, GA USA. [Fritsch, Valerie A.; Lentsch, Eric J.] Med Univ S Carolina, Charleston, SC 29425 USA. RP Lentsch, EJ (reprint author), Med Univ S Carolina, Dept Otolaryngol Head & Neck Surg, 135 Rutledge Ave,MSC 550, Charleston, SC 29425 USA. EM Elentsch@musc.edu FU Medical University of South Carolina, Department of Otolaryngology-Head and Neck FX The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This research was completed without the expenditure of grant funds. Material support in the form of software and office space was provided by the Medical University of South Carolina, Department of Otolaryngology-Head and Neck CR Batsakis JG, 2000, ADV ANAT PATHOL, V7, P282, DOI 10.1097/00125480-200007050-00002 Fletcher CDM, 2002, MODERN PATHOL, V15, P324, DOI 10.1038/modpathol.3880526 Gupta R, 2007, J CLIN PATHOL, V60, P472, DOI 10.1136/jcp.2005.033589 Howlader N, 2002, SEER CANC STAT REV 1 Kanner WA, 2010, J CUTAN PATHOL, V37, P744, DOI 10.1111/j.1600-0560.2010.01534.x Lewis James S Jr, 2008, Head Neck Pathol, V2, P103, DOI 10.1007/s12105-008-0055-4 Minami SB, 2008, AM J OTOLARYNG, V29, P123, DOI 10.1016/j.amjoto.2007.02.006 Romanach MJ, 2010, J ORAL PATHOL MED, V39, P335, DOI 10.1111/j.1600-0714.2009.00843.x Spector ME, 2011, OTOLARYNG HEAD NECK, V145, P242, DOI 10.1177/0194599811402167 Thompson LDR, 2003, CURR DIAGN PATHOL, V9, P384, DOI 10.1016/S0968-6053(03)00069-3 Thomas LD, 2002, AM INDIAN CULT RES J, V26, P153, DOI 10.1097/00000478-200202000-00002 Viswanathan Seethalakshmi, 2010, Head Neck Pathol, V4, P265, DOI 10.1007/s12105-010-0204-4 NR 12 TC 0 Z9 0 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD AUG PY 2014 VL 123 IS 8 BP 576 EP 583 DI 10.1177/0003489414525337 PG 8 WC Otorhinolaryngology SC Otorhinolaryngology GA AM0LV UT WOS:000339538000009 PM 24634155 ER PT J AU Damrose, EJ Cho, DY Goode, RL AF Damrose, Edward J. Cho, Do-Yeon Goode, Richard L. TI The Hybrid Tracheoesophageal Puncture Procedure: Indications and Outcomes SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE cancer; dilation; esophageal stenosis; laryngectomy; tracheoesophageal puncture; voice prosthesis ID TOTAL LARYNGECTOMY; VOICE PROSTHESIS; TRANSNASAL ESOPHAGOSCOPY; VOCAL REHABILITATION; RESTORATION; EXPERIENCE; DEVICES AB Objectives: This report aimed to describe a novel and efficient method of tracheoesophageal puncture using a hybrid device assembled from 2 commercially available puncture kits; to demonstrate the utility of this technique in the performance of primary and secondary procedures, under general and local anesthesia, with and without flap reconstruction; and to evaluate the efficacy of concurrent puncture and valve placement. Methods: Thirty-four patients who underwent either primary or secondary tracheoesophageal puncture for voice restoration. Charts were reviewed retrospectively for complications, time to first valve change, operative time, and blood loss. Results: Using this novel hybrid device, simultaneous puncture and valve placement was achieved in 34 consecutive patients. There was I major complication; blood loss was negligible; and the procedure could be accomplished in all cases. There were no cases of prosthesis failure as a result of the insertion technique. Conclusion: Concurrent tracheoesophageal puncture and voice prosthesis placement is a simple and efficient method of voice restoration in the laryngectomized patient and can be more easily accomplished with a hybrid device assembled from the components of 2 commercially available puncture kits. It can be performed under local as well as general anesthesia. The procedure is adaptable to a variety of clinical situations. C1 [Damrose, Edward J.; Cho, Do-Yeon; Goode, Richard L.] Stanford Univ, Med Ctr, Dept Otolaryngol Head & Neck Surg, Div Laryngol, Stanford, CA 94305 USA. RP Damrose, EJ (reprint author), Stanford Univ, Med Ctr, Dept Otolaryngol Head & Neck Surg, Div Laryngol, 801 Welch Rd, Stanford, CA 94305 USA. EM edamrose@stanford.edu CR [Anonymous], 2014, RUSCH RED RUBB ROB C Bozec A, 2010, EUR ARCH OTO-RHINO-L, V267, P751, DOI 10.1007/s00405-009-1138-x Deschler DG, 2011, LARYNGOSCOPE, V121, P1855, DOI 10.1002/lary.21910 Deschler DG, 2009, LARYNGOSCOPE, V119, P1353, DOI 10.1002/lary.20490 Doctor Vishal S, 2007, Curr Opin Otolaryngol Head Neck Surg, V15, P405, DOI 10.1097/MOO.0b013e3282f151e6 Doctor VS, 2008, J LARYNGOL OTOL, V122, P303, DOI 10.1017/S0022215107000084 Emerick KS, 2009, OTOLARYNG HEAD NECK, V140, P386, DOI 10.1016/j.otohns.2008.10.018 Leahy KP, 2010, ORL J OTO-RHINO-LARY, V72, P124, DOI 10.1159/000278257 LeBert B, 2009, ARCH OTOLARYNGOL, V135, P1190, DOI 10.1001/archoto.2009.166 Lenhard N, 2013, ANN R COLL SURG ENGL, V95, P309 Makitie AA, 2003, ANN OTO RHINOL LARYN, V112, P1007 McElhinney DB, 2012, CIRC-CARDIOVASC INTE, V5, P739, DOI 10.1161/CIRCINTERVENTIONS.112.976043 Op de Coul BMR, 2000, ARCH OTOLARYNGOL, V126, P1320 SELDINGER SI, 1953, ACTA RADIOL, V39, P368, DOI 10.3109/00016925309136722 Sidell D, 2010, ANN OTO RHINOL LARYN, V119, P37 SINGER MI, 1980, ANN OTO RHINOL LARYN, V89, P529 Starnes BW, 2013, J VASC SURG, V57, P829, DOI 10.1016/j.jvs.2012.11.043 NR 17 TC 0 Z9 0 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD AUG PY 2014 VL 123 IS 8 BP 584 EP 590 DI 10.1177/0003489414525591 PG 7 WC Otorhinolaryngology SC Otorhinolaryngology GA AM0LV UT WOS:000339538000010 PM 24642586 ER PT J AU Patel, R Uchida, D Feola, GP Meier, JD AF Patel, Rusha Uchida, Derek Feola, G. Peter Meier, Jeremy D. TI Bronchial Artery Pseudoaneurysm as an Unsuspected Cause of Hemoptysis in a Pediatric Patient SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE bronchoscopy; hemoptysis; pediatric; pseudoaneurysm ID EHLERS-DANLOS-SYNDROME; MASSIVE HEMOPTYSIS; EMBOLIZATION; MANAGEMENT; CHILDREN; DIAGNOSIS; ETIOLOGY; CT; IV AB Objective: Hemoptysis in the pediatric population may be caused by foreign body aspiration, cystic fibrosis, bronchiectasis, or infection. Vascular causes are uncommon. We present a rare cause of hemoptysis related to a bronchial artery pseudoaneurysm. Methods: We report the case of a child with a bronchial artery pseudoaneurysm causing hemoptysis and describe the clinical evaluation, treatment, and outcome. Results: A 12-year-old girl presented to a tertiary children's hospital with a history of daily, intermittent, moderate-volume hemoptysis. Rigid bronchoscopy showed a fresh clot occluding the right bronchus intermedius. Computed tomography angiogram was concerning for mild external vascular compression of the right mainstem bronchus. A bronchial arteriogram showed a right mid-bronchial pseudoaneurysm, which was embolized without complication. On repeat bronchoscopy, thrombus was removed from the bronchus intermedius with no new active bleeding. The patient was discharged in stable condition and did not have any more episodes of hemoptysis. Additional medical work-up did not reveal another source of the patient's bleeding. Conclusion: Hemoptysis in the pediatric population can be inflammatory, infectious, or due to systemic disease. Although extremely rare, bronchial artery pseudoaneurysm should be considered in cases of moderate to severe intermittent hemoptysis without another identifiable cause. Bronchial angiography can be both diagnostic and therapeutic. C1 [Patel, Rusha; Meier, Jeremy D.] Univ Utah, Div Otolaryngol Head & Neck Surg, Sch Med, Salt Lake City, UT 84132 USA. [Uchida, Derek] Univ Utah, Dept Pediat, Sch Med, Salt Lake City, UT 84132 USA. [Feola, G. Peter] Primary Childrens Med Ctr, Dept Radiol, Salt Lake City, UT 84103 USA. RP Meier, JD (reprint author), Univ Utah, Div Otolaryngol Head & Neck Surg, 50 North Med Dr,Room 3C120, Salt Lake City, UT 84132 USA. EM jeremy.meier@imail.org CR Abu-Kishk I, 2012, PEDIATR EMERG CARE, V28, P1206, DOI 10.1097/PEC.0b013e318271c107 Batra PS, 2001, ARCH OTOLARYNGOL, V127, P377 Chun JY, 2010, CARDIOVASC INTER RAD, V33, P240, DOI 10.1007/s00270-009-9788-z CossBu JA, 1997, PEDIATRICS, V100, part. no., DOI 10.1542/peds.100.3.e7 Fernando HC, 1998, ARCH SURG-CHICAGO, V133, P862, DOI 10.1001/archsurg.133.8.862 Godfrey S, 2004, PEDIATR PULM, V37, P476, DOI 10.1002/ppul.20020 HAYAKAWA K, 1992, CARDIOVASC INTER RAD, V15, P154, DOI 10.1007/BF02735578 Hirshberg B, 1997, CHEST, V112, P440, DOI 10.1378/chest.112.2.440 Khalil A, 2007, AM J ROENTGENOL, V188, pW117, DOI 10.2214/AJR.05.1578 Kierse R, 2004, J VASC INTERV RADIOL, V15, P1133, DOI 10.1097/01.RVI.0000133223.71673.22 Lorenz Jonathan, 2012, Semin Intervent Radiol, V29, P155, DOI 10.1055/s-0032-1326923 Mandeville K, 2008, EUR J VASC ENDOVASC, V36, P353, DOI 10.1016/j.ejvs.2008.02.011 Naidu SG, 2007, J VASC SURG, V46, P1036, DOI 10.1016/j.jvs.2007.05.053 Noe GD, 2011, CLIN RADIOL, V66, P869, DOI 10.1016/j.crad.2011.03.001 REMY J, 1984, AM J ROENTGENOL, V143, P963 REMY J, 1974, ANN RADIOL, V17, P5 Restrepo CS, 2012, SEMIN ULTRASOUND CT, V33, P552, DOI 10.1053/j.sult.2012.04.001 Rossi PI, 1998, J VASC SURG, V27, P549, DOI 10.1016/S0741-5214(98)70331-3 Sidman JD, 2001, LARYNGOSCOPE, V111, P33, DOI 10.1097/00005537-200101000-00006 Hurt K, 2012, PAEDIATR RESPIR REV, V13, P200, DOI 10.1016/j.prrv.2012.01.003 Yoon W, 2002, RADIOGRAPHICS, V22, P1395, DOI 10.1148/rg.226015180 NR 21 TC 1 Z9 1 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD AUG PY 2014 VL 123 IS 8 BP 591 EP 595 DI 10.1177/0003489414525586 PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA AM0LV UT WOS:000339538000011 PM 24642588 ER PT J AU Koleli, H Paltura, C Sahin-Yilmaz, A Topak, M Develioglu, ON Kulekci, M AF Koleli, Hakan Paltura, Ceki Sahin-Yilmaz, Asli Topak, Murat Develioglu, Omer Necati Kulekci, Mehmet TI Peak Nasal Inspiratory Flowmetry for Selection of Patients for Radiofrequency Ablation of Turbinates SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE chronic nasal obstruction; inferior turbinate hypertrophy; peak nasal inspiratory flow; radiofrequency ablation; topical vasoconstrictor test; visual analog scale ID OBJECTIVE ASSESSMENT; ACOUSTIC RHINOMETRY; HYPERTROPHY; OBSTRUCTION; RHINOMANOMETRY; TURBINOPLASTY; REDUCTION; PATENCY AB Objectives: Our goals were to investigate (1) the effectiveness of the topical vasoconstrictor test (TVT) and peak nasal inspiratory flow (PNIF) measurement for the selection of patients with inferior turbinate hypertrophy (ITH) who will benefit from radiofrequency ablation (RFA) of the turbinates and (2) the efficacy of the TVT and PNIF in follow-up of treatment outcomes. Methods: Patients with bilateral chronic nasal obstruction due to ITH underwent assessment with a visual analog scale (VAS) and PNIF before and after the TVT. Twenty patients with symptom improvement according to VAS and PNIF results were enrolled in the study. These patients underwent RFA, and PNIF and VAS scores were determined before and 1 and 6 months after the TVT. These results were compared to evaluate the preoperative prediction of RFA treatment success. Results: Radiofrequency ablation of the turbinates resulted in significant changes in objective and subjective scores. Preoperative (baseline) subjective and objective responses to decongestant were positively correlated (P = .024 and P < .05, respectively). Preoperative (baseline) objective responses to decongestant were significantly correlated with the objective outcomes of surgery (P = .006 and P < .05, respectively). Conclusion: The combined use of PNIF and the TVT allows for the preoperative prediction of the success of RFA and the selection of patients who will benefit most from RFA. C1 [Koleli, Hakan] Malatya State Hosp, TR-44000 Malatya, Turkey. [Paltura, Ceki] Haseki Educ & Res Hosp Istanbul, Istanbul, Turkey. [Sahin-Yilmaz, Asli] Umraniye Educ & Res Hosp, Istanbul, Turkey. [Topak, Murat; Develioglu, Omer Necati; Kulekci, Mehmet] Taksim Educ & Res Hosp, Istanbul, Turkey. RP Koleli, H (reprint author), Malatya State Hosp, ENT Dept, TR-44000 Malatya, Turkey. EM hakankoleli@gmail.com CR Back LJJ, 2002, LARYNGOSCOPE, V112, P1806 Cavaliere M, 2005, OTOLARYNG HEAD NECK, V133, P972, DOI 10.1016/j.otohns.2005.08.006 Chang D, 2004, CURR OPIN OTOLARYNGO, V12, P53 Corey JP, 2009, BALLENGERS OTORHINOL, P493 Farmer SEJ, 2009, J LARYNGOL OTOL, V123, P309, DOI 10.1017/S0022215108002818 Ganslmayer M, 1999, ALLERGY, V54, P974, DOI 10.1034/j.1398-9995.1999.00160.x Harar RPS, 2001, RHINOLOGY, V39, P211 Harrill WC, 2007, LARYNGOSCOPE, V117, P1912, DOI 10.1097/MLG.0b013e3181271414 HOLMSTROM M, 1990, Rhinology (Utrecht), V28, P191 Jackson LE, 1999, PLAST RECONSTR SURG, V103, P300, DOI 10.1097/00006534-199901000-00049 JONES AS, 1991, CLIN OTOLARYNGOL, V16, P206, DOI 10.1111/j.1365-2273.1991.tb01978.x Kjaergaard T, 2009, LARYNGOSCOPE, V119, P1628, DOI 10.1002/lary.20505 Li KK, 1998, OTOLARYNG HEAD NECK, V119, P569, DOI 10.1016/S0194-5998(98)70013-0 LUND VJ, 1992, OTOLARYNG CLIN N AM, V25, P803 Nease CJ, 2004, OTOLARYNG HEAD NECK, V130, P291, DOI 10.1016/j.otohns.2003.11.003 Scadding GK, 2004, INVESTIGATIVE RHINOL Volk GF, 2010, ARCH OTOLARYNGOL, V136, P1015, DOI 10.1001/archoto.2010.161 Wilson AM, 2003, RHINOLOGY, V41, P16 Yilmaz M, 2006, AM J RHINOL, V20, P32 NR 19 TC 1 Z9 1 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD JUL PY 2014 VL 123 IS 7 BP 457 EP 460 DI 10.1177/0003489414526694 PG 4 WC Otorhinolaryngology SC Otorhinolaryngology GA AJ8RN UT WOS:000337974800001 PM 24824080 ER PT J AU Todd, NW Daraei, P AF Todd, Norman Wendell, Jr. Daraei, Pedram TI Morphologic Variations of Clinically Normal Mallei and Incudes SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE incus; malleus; mastoid; temporal bone ID AUDITORY OSSICLES AB Objectives: Various features and shapes of malleus and incus are reported. Partially or unaddressed are their bilateral symmetry, correlation with otitis media, and concordance of features and shapes. Such information may contribute to the understanding of malleus and incus ontogeny and the installation and function of implantable middle ear devices. We sought to address the following hypotheses: (1) a cranium's malleus and incus have bilateral symmetry, with respect to their features and shapes; (2) features and shapes of malleus and incus are unrelated to the mastoid size indicator of childhood otitis media; and (3) an ear's malleus and incus have concordant features and shapes (ie, the presence or absence of a feature or shape of a malleus or incus is associated with the presence or absence of another feature or shape in that ear's malleus or incus). Methods: Postmortem material-analysis prevalence study of 41 adult crania without clinical otitis media. Mastoid sizes were assessed radiographically. Results: Most mallei had lateral processes and inflected manubrium tips. Most incudes had concave superior borders of their short processes, non-notched inferior borders of their short processes, and anteriorly curved anterior edges of their long processes. Only 1 feature, absence of the lateral process of the malleus, was suggested to have a relationship to small mastoid size. Concordance was not found for any shape or feature of the malleus or incus. Conclusion: Clinically normal mallei and incudes have feature and shape variations that are mostly bilaterally symmetric. C1 [Todd, Norman Wendell, Jr.] Emory Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, Atlanta, GA 30322 USA. [Daraei, Pedram] Emory Univ, Sch Med, Atlanta, GA 30322 USA. RP Todd, NW (reprint author), Emory Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, 2015 Uppergate Dr NE, Atlanta, GA 30322 USA. EM ntodd@emory.edu FU Department of Otolaryngology, Emory University FX The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: Department of Otolaryngology, Emory University. CR Ars B., 2003, FIBROCARTILAGINOUS E Bluestone CD, 1996, PEDIATR INFECT DIS J, V15, P281, DOI 10.1097/00006454-199604000-00002 Bluestone CD, 2005, EUSTACHIAN TUBE STRU Cinamon U, 2009, EUR ARCH OTO-RHINO-L, V266, P781, DOI 10.1007/s00405-009-0941-8 Flohr S, 2010, ANAT REC, V293, P2094, DOI 10.1002/ar.21271 Gundersen T, 1971, PROSTHESES OSSICULAR HARADA O, 1972, PLAST RECONSTR SURG, V50, P48, DOI 10.1097/00006534-197207000-00008 Jain D, 2013, J FORENSIC LEG MED, V20, P255, DOI 10.1016/j.jflm.2012.09.020 Kirikae I., 1960, STRUCTURE FUNCTION M Luntz M, 2001, LARYNGOSCOPE, V111, P1614, DOI 10.1097/00005537-200109000-00023 Park K, 2009, ACTA OTO-LARYNGOL, V129, P419, DOI 10.1080/00016480802587846 Passos-Bueno MR, 2009, AM J MED GENET A, V149A, P1853, DOI 10.1002/ajmg.a.32950 Quam R, 2008, J HUM EVOL, V54, P414, DOI 10.1016/j.jhevol.2007.10.005 Todd NW, 2005, LARYNGOSCOPE, V115, P1548, DOI 10.1097/01.mlg.0000173171.32899.4e Todd NW, 2013, ANN OTO RHINOL LARYN, V122, P60 TURGUT S, 1992, J LARYNGOL OTOL, V106, P485, DOI 10.1017/S0022215100119942 NR 16 TC 0 Z9 0 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD JUL PY 2014 VL 123 IS 7 BP 461 EP 467 DI 10.1177/0003489414527228 PG 7 WC Otorhinolaryngology SC Otorhinolaryngology GA AJ8RN UT WOS:000337974800002 PM 24690987 ER PT J AU Nakamaru, Y Fujima, N Takagi, D Tsukahara, A Yoshida, D Fukuda, S AF Nakamaru, Yuji Fujima, Noriyuki Takagi, Dai Tsukahara, Akiko Yoshida, Daisuke Fukuda, Satoshi TI Prediction of the Attachment Site of Sinonasal Inverted Papillomas by Preoperative Imaging SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE attachment site; CT; MRI; sinonasal inverted papilloma ID BEAM COMPUTED-TOMOGRAPHY; MR; METAANALYSIS; ECHO; CT AB Objective: Accurate preoperative identification of the attachment site is the key to the successful surgical management of sinonasal inverted papillomas (IPs). This study investigated the value of preoperative imaging to identify the attachment sites of IPs. Methods: We analyzed 10 consecutive patients with pathologically proven IPs. Two radiologists predicted the attachment sites of IPs from computed tomography (CT), 3.0 Tesla magnetic resonance imaging (3.0T MRI), 1.5T MRI, and CT plus 3.0T MRI. The actual tumor attachment sites were confirmed via pathological examination of specimens and compared with the predicted sites. Results: Computed tomography showed the highest sensitivity (P < .0001), although both MRI formats showed greater specificity (P < .0001). The sensitivity of MRI plus CT was equal to that of CT and better than that of MRI (P <.0001), whereas its specificity was better than that of CT (P < .0001) and comparable to that of MRI. Prediction using 3.0T MRI appeared slightly superior to that using 1.5T MRI in terms of sensitivity and specificity, although the differences were not significant. Conclusion: Computed tomography and MRI had different features for prediction of sinonasal IP attachment sites. Preoperative CT plus MRI provided more useful information than CT or MRI alone. C1 [Nakamaru, Yuji; Takagi, Dai; Fukuda, Satoshi] Hokkaido Univ, Grad Sch Med, Dept Otolaryngol Head & Neck Surg, Sapporo, Hokkaido, Japan. [Fujima, Noriyuki; Tsukahara, Akiko; Yoshida, Daisuke] Hokkaido Univ, Grad Sch Med, Dept Radiol, Sapporo, Hokkaido, Japan. RP Nakamaru, Y (reprint author), Hokkaido Univ, Grad Sch Med, Dept Otolaryngol Head & Neck Surg, Kita Ku, North 15,West 7, Sapporo, Hokkaido, Japan. EM nmaru@med.hokudai.ac.jp CR Barbier EL, 2002, MAGNET RESON MED, V48, P735, DOI 10.1002/mrm.10255 Bhalla RK, 2009, RHINOLOGY, V47, P345, DOI 10.4193/Rhin08.229 Busquets JM, 2006, OTOLARYNG HEAD NECK, V134, P476, DOI 10.1016/j.otohns.2005.11.038 Cakli H, 2012, EUR ARCH OTO-RHINO-L, V269, P711, DOI 10.1007/s00405-011-1781-x Chiu AG, 2006, LARYNGOSCOPE, V116, P1617, DOI 10.1097/01.mlg.0000230401.88711.e6 Cihangiroglu M, 2009, EUR J RADIOL, V69, P454, DOI 10.1016/j.ejrad.2007.11.023 Iimura J, 2009, AURIS NASUS LARYNX, V36, P416, DOI 10.1016/j.anl.2008.08.007 Komori M, 2012, OTOL NEUROTOL, V33, P1353, DOI 10.1097/MAO.0b013e31826a5260 Lawson W, 2003, LARYNGOSCOPE, V113, P1548, DOI 10.1097/00005537-200309000-00026 Lee DK, 2007, AM J NEURORADIOL, V28, P618 Li PMMC, 2013, LARYNGOSCOPE, V123, P1247, DOI 10.1002/lary.23759 Mirza S, 2007, J LARYNGOL OTOL, V121, P857, DOI 10.1017/S002221510700624X Sham CL, 2008, AM J RHINOL, V22, P144, DOI 10.2500/ajr.2008.22.3142 Verhappen MH, 2012, AM J NEURORADIOL, V33, P1239, DOI 10.3174/ajnr.A2949 VRABEC DP, 1975, LARYNGOSCOPE, V85, P186, DOI 10.1288/00005537-197501000-00014 Yousuf K, 2007, AM J RHINOL, V21, P32, DOI 10.2500/air.2007.21.2984 NR 16 TC 0 Z9 0 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD JUL PY 2014 VL 123 IS 7 BP 468 EP 474 DI 10.1177/0003489414527224 PG 7 WC Otorhinolaryngology SC Otorhinolaryngology GA AJ8RN UT WOS:000337974800003 PM 24690985 ER PT J AU Levendoski, EE Sundarrajan, A Sivasankar, MP AF Levendoski, Elizabeth Erickson Sundarrajan, Anusha Sivasankar, M. Preeti TI Reducing the Negative Vocal Effects of Superficial Laryngeal Dehydration With Humidification SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE laryngeal dehydration; humidification; voice production; phonation threshold pressure; vocal fatigue ID PHONATION THRESHOLD PRESSURE; DESICCATION CHALLENGE; VOICE; HYDRATION; FATIGUE; SALINE; WATER; TASK AB Objectives: Environmental humidification is a simple, cost-effective method believed to reduce superficial laryngeal drying. This study sought to validate this belief by investigating whether humidification treatment would reduce the negative effects of superficial laryngeal dehydration on phonation threshold pressure (PTP). Phonation threshold pressure data analysis may be vulnerable to bias because of lack of investigator blinding. Consequently, this study investigated the extent of PTP analysis reliability between unblinded and blinded investigators. Methods: Healthy male and female adults were assigned to a vocal fatigue (n = 20) or control group (n = 20) based on their responses to a questionnaire. PTP was assessed after 2 hours of mouth breathing in low humidity (dehydration challenge), following a 5-minute break in ambient humidity, and after 2 hours of mouth breathing in high humidity (humidification). Results: PTP significantly increased following the laryngeal dehydration challenge. After humidification, PTP returned toward baseline. These effects were observed in both subject groups. PTP measurements were highly correlated between the unblinded and blinded investigator. Conclusions: Humidification may be an effective approach to decrease the detrimental voice effects of superficial laryngeal dehydration. These data lay the foundation for future investigations aimed at preventing and treating the negative voice changes associated with chronic, surface laryngeal drying. C1 [Levendoski, Elizabeth Erickson; Sundarrajan, Anusha; Sivasankar, M. Preeti] Purdue Univ, Dept Speech Language & Hearing Sci, W Lafayette, IN 47907 USA. [Levendoski, Elizabeth Erickson] Univ Wisconsin, Div Otolaryngol Head & Neck Surg, Dept Surg, Sch Med & Publ Hlth, Madison, WI USA. RP Sivasankar, MP (reprint author), Purdue Univ, Dept Speech Language & Hearing Sci, W Lafayette, IN 47907 USA. EM msivasankar@purdue.edu FU National Institutes of Health/National Institute on Deafness and Other Communication Disorders [008690] FX The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: Funding was provided from grant 008690 (National Institutes of Health/National Institute on Deafness and Other Communication Disorders). CR Chang A, 2004, J VOICE, V18, P454, DOI 10.1016/j.jvoice.2004.01.004 Erickson E, 2010, J SPEECH LANG HEAR R, V53, P75, DOI 10.1044/1092-4388(2009/09-0024) Erickson-Levendoski E, 2011, J VOICE, V25, pE215, DOI 10.1016/j.jvoice.2011.02.009 Fisher KV, 1997, J SPEECH LANG HEAR R, V40, P1122 Fisher KV, 2001, J SPEECH LANG HEAR R, V44, P354, DOI 10.1044/1092-4388(2001/029) Hamdan AL, 2011, AM J OTOLARYNG, V32, P124, DOI 10.1016/j.amjoto.2009.12.001 Hamdan AL, 2007, J VOICE, V21, P495, DOI 10.1016/j.jvoice.2006.01.009 Hemler RJB, 1997, J VOICE, V11, P295, DOI 10.1016/S0892-1997(97)80007-0 Jiang J, 1999, J VOICE, V13, P51, DOI 10.1016/S0892-1997(99)80061-7 Kostyk BE, 1998, J VOICE, V12, P287, DOI 10.1016/S0892-1997(98)80019-2 Leydon C, 2010, J VOICE, V24, P637, DOI 10.1016/j.jvoice.2009.06.001 Plexico LW, 2011, AM J SPEECH-LANG PAT, V20, P348, DOI 10.1044/1058-0360(2011/10-0066) Polit DF, 2011, INT J NURS STUD, V48, P636, DOI 10.1016/j.ijnurstu.2011.02.010 Roy N, 2003, J VOICE, V17, P331, DOI 10.1067/S0892-1997(03)00078-X Sandage MJ, J SPEECH LANG HEAR R Sivasankar M, 2002, J VOICE, V16, P172, DOI 10.1016/S0892-1997(02)00087-5 Sivasankar M, 2008, J SPEECH LANG HEAR R, V51, P1494, DOI 10.1044/1092-4388(2008/07-0181) Sivasankar M, 2009, LARYNGOSCOPE, V119, P1658, DOI 10.1002/lary.20530 Sivasankar M, 2003, J SPEECH LANG HEAR R, V46, P1416, DOI 10.1044/1092-4388(2003/110) Solomon NP, 2007, J VOICE, V21, P541, DOI 10.1016/j.jvoice.2006.04.002 Solomon NP, 2003, J VOICE, V17, P31, DOI 10.1016/S0892-1997(03)00029-8 Sundarrajan A, 2012, AM SPEECH LANG HEAR Tanner K, 2007, J SPEECH LANG HEAR R, V50, P635, DOI 10.1044/1092-4388(2007/045) Tanner K, 2013, LARYNGOSCOPE, V123, P2787, DOI 10.1002/lary.24148 Tanner K, 2010, J SPEECH LANG HEAR R, V53, P1555, DOI 10.1044/1092-4388(2010/09-0249) TITZE IR, 1988, J ACOUST SOC AM, V83, P1536, DOI 10.1121/1.395910 VERDOLINI K, 1994, J SPEECH HEAR RES, V37, P1001 Verdolini K, 2002, J SPEECH LANG HEAR R, V45, P268, DOI 10.1044/1092-4388(2002/021) VERDOLINIMARSTON K, 1990, J VOICE, V4, P142, DOI 10.1016/S0892-1997(05)80139-0 NR 29 TC 0 Z9 0 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD JUL PY 2014 VL 123 IS 7 BP 475 EP 481 DI 10.1177/0003489414527230 PG 7 WC Otorhinolaryngology SC Otorhinolaryngology GA AJ8RN UT WOS:000337974800004 PM 24690983 ER PT J AU Guidi, JL Wetmore, RF Sobol, SE AF Guidi, Jessica L. Wetmore, Ralph F. Sobol, Steven E. TI Risk of Otitis Externa Following Manual Cerumen Removal SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE cerumen removal; otitis externa; sterilization ID IMPACTED CERUMEN AB Objectives: Based on an interpretation of a recent Joint Commission protocol to sterilize instruments coming into contact with mucous membranes, there has been institutional interest in sterile packaging of cerumen curettes used for manual cerumen removal. To date, there are no studies that have assessed the risk of otitis externa (OE) following cerumen removal and the utility of sterile packaging is questionable. The objective of this study is to assess the incidence of OE following cerumen disimpaction prior to the implementation of sterile packaging at our institution. Methods: This was a retrospective chart review. Over a 1-year period, 1457 episodes of manual cerumen removal took place in the otolaryngology clinic. Charts were assessed for signs or symptoms of OE within 2 weeks of the procedure through follow-up phone calls and clinic visits in the otolaryngology division. Results: There were no patients who followed up with symptoms or signs suggestive of OE in the 2-week postprocedure period. Conclusion: There is no evidence that OE is a complication of manual cerumen removal when performed by otolaryngologists using clean technique. Unnecessary sterilization of tools leads to increased cost and time for this common outpatient procedure performed by the otolaryngologist. C1 [Guidi, Jessica L.; Wetmore, Ralph F.; Sobol, Steven E.] Childrens Hosp Philadelphia, Div Otolaryngol, Philadelphia, PA 19104 USA. [Wetmore, Ralph F.; Sobol, Steven E.] Univ Penn, Perelman Sch Med, Dept Otorhinolaryngol Head & Neck Surg, Philadelphia, PA 19104 USA. RP Sobol, SE (reprint author), Childrens Hosp Philadelphia, Div Otolaryngol, 34th St & Civ Ctr Blvd,1 Wood Ctr, Philadelphia, PA 19104 USA. EM sobols@email.chop.edu CR Grandis JR, 2004, LANCET INFECT DIS, V4, P34, DOI 10.1016/S1473-3099(03)00858-2 Guest JF, 2004, QJM-INT J MED, V97, P477, DOI 10.1093/qjmed/hch082 McCarter DF, 2007, AM FAM PHYSICIAN, V75, P1523 Nussinovitch M, 2004, INT J PEDIATR OTORHI, V68, P433, DOI 10.1016/j.ijporl.2003.11.014 Roland PS, 2008, OTOLARYNG HEAD NECK, V139, pS1, DOI 10.1016/j.otohns.2008.06.026 SHARP JF, 1990, BRIT MED J, V301, P1251 ZIKK D, 1991, NEW ENGL J MED, V325, P969 NR 7 TC 0 Z9 0 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD JUL PY 2014 VL 123 IS 7 BP 482 EP 484 DI 10.1177/0003489414526850 PG 3 WC Otorhinolaryngology SC Otorhinolaryngology GA AJ8RN UT WOS:000337974800005 PM 24690982 ER PT J AU MacKeith, SAC Bottrill, ID Ramsden, JD AF MacKeith, Samuel A. C. Bottrill, Ian D. Ramsden, James D. TI Simultaneous Labyrinthectomy With Cochlear Implantation in Patients With Bilateral Menire's Disease SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE bilateral; cochlear implant; labyrinthectomy; Meniere's disease; simultaneous ID MENIERES-DISEASE; EAR AB Objective: The development of second-side Meniere's disease in the only remaining serviceable ear is difficult to treat. We describe an intervention to control disabling disease combining a labyrinthectomy and cochlear implant to restore hearing. Methods: Following a thorough preoperative assessment and consenting process, 2 patients underwent labyrinthectomy of the affected ear with simultaneous cochlear implantation. Results: Both patients achieved control of Meniere's attacks with improved hearing rehabilitation. Oscillopsia was noted by both patients. Both patients were pleased to have undergone the treatment. Conclusion: Severe symptomatic second-side Meniere's disease in the only hearing ear is uncommon. We report the successful treatment of 2 patients in this difficult management scenario, by simultaneous surgical labyrinthectomy and cochlear implantation. We propose this as a potential management strategy in this rare but complex group of patients in whom all less destructive measures have failed. C1 [MacKeith, Samuel A. C.; Bottrill, Ian D.; Ramsden, James D.] John Radcliffe Hosp, Dept Otolaryngol Head & Neck Surg, Oxford OX3 9DU, England. RP MacKeith, SAC (reprint author), John Radcliffe Hosp, Dept Otolaryngol Head & Neck Surg, Oxford OX3 9DU, England. EM samuelmackeith@doctors.org.uk CR CHEN DA, 1988, LARYNGOSCOPE, V98, P1170 Della Santina Charles C, 2010, Cochlear Implants Int, V11 Suppl 2, P2, DOI 10.1179/146701010X12726366068454 Facer GW, 2000, AM J OTOL, V21, P336, DOI 10.1016/S0196-0709(00)80041-1 KVETON JF, 1989, LARYNGOSCOPE, V99, P610 Lambert PR, 1992, LARYNGOSCOPE, V12, P814 Lustig LR, 2003, OTOL NEUROTOL, V24, P397, DOI 10.1097/00129492-200305000-00009 MacKeith SAC, 2014, OTOL NEUROTOL, V35, P305, DOI 10.1097/MAO.0b013e3182a5d304 Morgan M, 1999, J LARYNGOL OTOL, V113, P666 RAMSDEN RT, 1991, J LARYNGOL OTOL, V105, P729, DOI 10.1017/S0022215100117141 SCHUKNECHT H F, 1957, Acta Otolaryngol Suppl, V132, P1 Wareing M J, 1997, Ear Nose Throat J, V76, P664 Wareing MJ, 1997, ENT-EAR NOSE THROAT, V76, P668 Wareing MJ, 1997, ENT-EAR NOSE THROAT, V76, P671 Zanetti D, 2008, AURIS NASUS LARYNX, V35, P562, DOI 10.1016/j.anl.2007.11.011 ZWOLAN TA, 1993, AM J OTOL, V14, P220 NR 15 TC 0 Z9 0 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD JUL PY 2014 VL 123 IS 7 BP 485 EP 489 DI 10.1177/0003489414527226 PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA AJ8RN UT WOS:000337974800006 PM 24690980 ER PT J AU Zhao, W Xu, W Yang, WW AF Zhao, Wan Xu, Wen Yang, Wei Wei TI Neuroregeneration in the Nucleus Ambiguus After Recurrent Laryngeal Nerve Avulsion in Rats SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE recurrent laryngeal nerve; nucleus ambiguus; neuroregeneration; avulsion ID NEURAL STEM-CELLS; ADULT SPINAL-CORD; CEREBRAL-ISCHEMIA; TEMPORAL PROFILE; MOTONEURON LOSS; GENE-TRANSFER; FACIAL-NERVE; INJURY; NEUROGENESIS; NESTIN AB Objectives: The objective was to investigate neuroregeneration, the origins of newborn cells and the proliferation of neuronal and glial cells in the nucleus ambiguus (NA) after ipsilateral recurrent laryngeal nerve (RLN) avulsion. Methods: All of the animals received a CM-Dil injection in the left lateral ventricle. Forty-five adult rats were subjected to a left RLN avulsion injury, while 9 rats were used as controls. 5-Bromo-2-deoxyuridine (BrdU) was injected intraperitoneally. Neuron quantification and immunohistochemical analysis were performed in the brain stems at different time points after RLN injury. Results: After RLN avulsion, CM-Dil labeled neural progenitor cells (NPCs) migrated to the ipsilateral NA and differentiated into astrocytes but not into neurons. In the NA, the neuronal cells re-expressed nestin. Only a small number of neuronal and glial cells in the NA showed BrdU immunoreactivity. Conclusions: After RLN avulsion, the NPCs in the ependymal layer of the fourth ventricle or central canal are activated, migrate to the lesion in the NA and differentiate exclusively into astrocytes. The newborn neural stem cells in the NA may arise from the mature region neurons. The presence of both cell types in the NA may play a role in repairing RLN injuries. C1 [Zhao, Wan; Xu, Wen; Yang, Wei Wei] Capital Med Univ, Dept Otorhinolaryngol Head Neck Surg, Beijing Tongren Hosp, Beijing 100730, Peoples R China. RP Xu, W (reprint author), Capital Med Univ, Dept Otorhinolaryngol Head Neck Surg, Beijing Tongren Hosp, 1 Dongjiaominxiang, Beijing 100730, Peoples R China. EM entwen@trhos.com FU Programs of National Natural Science Foundation of China [81170901]; Programs of Beijing Natural Science Foundation [7132053] FX The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This research was supported by Programs of National Natural Science Foundation of China (81170901) and Programs of Beijing Natural Science Foundation (7132053). CR ABERCROMBIE M, 1946, ANAT REC, V94, P239, DOI 10.1002/ar.1090940210 Azari MF, 2005, EUR J NEUROL, V12, P638, DOI 10.1111/j.1468-1331.2005.01066.x Bauer S, 2007, NAT REV NEUROSCI, V8, P221, DOI 10.1038/nrn2054 Bye N, 2011, J NEUROSCI RES, V89, P986, DOI 10.1002/jnr.22635 Chiang FY, 2005, SURGERY, V137, P342, DOI 10.1016/j.surg.2004.09.008 Christie KJ, 2013, FRONT CELL NEUROSCI, V6, DOI 10.3389/fncel.2012.00070 CLARKE SR, 1994, NEUROREPORT, V5, P1885, DOI 10.1097/00001756-199410000-00011 Danilov AI, 2006, EUR J NEUROSCI, V23, P394, DOI 10.1111/j.1460-9568.2005.04563.x Decimo I, 2011, STEM CELLS, V29, P2062, DOI 10.1002/stem.766 Fagerlund M, 2011, RESTOR NEUROL NEUROS, V29, P47, DOI 10.3233/RNN-2011-0578 Gage FH, 2000, SCIENCE, V287, P1433, DOI 10.1126/science.287.5457.1433 Gordon RJ, 2007, NEUROSCIENCE, V146, P1704, DOI 10.1016/j.neuroscience.2007.03.011 Goritz C, 2012, CELL STEM CELL, V10, P657, DOI 10.1016/j.stem.2012.04.005 Hamilton LK, 2009, NEUROSCIENCE, V164, P1044, DOI 10.1016/j.neuroscience.2009.09.006 Hernandez-Morato I, 2013, J ANAT, V222, P451, DOI 10.1111/joa.12031 Hou SW, 2008, STROKE, V39, P2837, DOI 10.1161/STROKEAHA.107.510982 Hydman J, 2005, LARYNGOSCOPE, V115, P619, DOI 10.1097/01.mlg.0000161362.43320.b2 Johansson CB, 1999, CELL, V96, P25, DOI 10.1016/S0092-8674(00)80956-3 Kreuzberg M, 2010, EXP NEUROL, V226, P90, DOI 10.1016/j.expneurol.2010.08.006 Kronenberg G, 2005, J CEREBR BLOOD F MET, V25, P1613, DOI 10.1038/sj.jcbfm.9600156 Kuroda T, 2002, J CHEM NEUROANAT, V24, P137, DOI 10.1016/S0891-0618(02)00042-X LENDAHL U, 1990, CELL, V60, P585, DOI 10.1016/0092-8674(90)90662-X Leong SY, 2011, NEUROCHEM INT, V59, P382, DOI 10.1016/j.neuint.2010.12.024 Li Y, 1999, BRAIN RES, V838, P1, DOI 10.1016/S0006-8993(99)01502-4 Marzo SJ, 2010, LARYNGOSCOPE, V120, P2264, DOI 10.1002/lary.21077 Mattsson P, 1999, BRAIN RES BULL, V49, P333, DOI 10.1016/S0361-9230(98)00178-6 Mori Y, 2007, LARYNGOSCOPE, V117, P1313, DOI 10.1097/MLG.0b013e31805f681f Moro K, 2006, BRAIN RES, V1076, P1, DOI 10.1021/j.brainres.2005.12.119 Nakayama D, 2010, EUR J NEUROSCI, V31, P90, DOI 10.1111/j.1460-9568.2009.07043.x Navarro X, 2007, PROG NEUROBIOL, V82, P163, DOI 10.1016/j.pneurobio.2007.06.005 NOWAKOWSKI RS, 1989, J NEUROCYTOL, V18, P311, DOI 10.1007/BF01190834 Okano H, 2008, PHILOS T R SOC B, V363, P2111, DOI 10.1098/rstb.2008.2264 Parent JM, 2006, HIPPOCAMPUS, V16, P321, DOI 10.1002/hipo.20166 Paxinos G, 1986, RAT BRAIN STEREOTAXI, V2nd Pitman MJ, 2013, ANN OTO RHINOL LARYN, V122, P283 REYNOLDS BA, 1992, SCIENCE, V255, P1707, DOI 10.1126/science.1553558 Saito K, 2003, BRAIN RES, V962, P61, DOI 10.1016/S0006-8993(02)03933-1 Shiotani A, 2007, ANN OTO RHINOL LARYN, V116, P115 Takaoka T, 2009, NEUROSCI RES, V65, P353, DOI 10.1016/j.neures.2009.08.012 Tang HD, 2009, NEUROBIOL AGING, V30, P299, DOI 10.1016/j.neurobiolaging.2007.06.004 NR 40 TC 1 Z9 1 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD JUL PY 2014 VL 123 IS 7 BP 490 EP 499 DI 10.1177/0003489414524170 PG 10 WC Otorhinolaryngology SC Otorhinolaryngology GA AJ8RN UT WOS:000337974800007 PM 24627406 ER PT J AU Sugaya, A Fukushima, K Kasai, N Ojima, T Takahashi, G Nakagawa, T Murai, S Nakajima, Y Nishizaki, K AF Sugaya, Akiko Fukushima, Kunihiro Kasai, Norio Ojima, Toshiyuki Takahashi, Goro Nakagawa, Takashi Murai, Seiko Nakajima, Yasoichi Nishizaki, Kazunori TI Effectiveness of Domain-Based Intervention for Language Development in Japanese Hearing-Impaired Children: A Multicenter Study SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE before-after study; hearing impairment; language development; language intervention ID RANDOMIZED CONTROLLED-TRIAL; FAST FORWORD; SPEECH; OUTCOMES; PARENTS AB Objective: Decreasing language delay in hearing-impaired children is a key issue in the maintenance of their quality of life. Language training has been presented mainly by experience-based training; effective intervention programs are crucially important for their future. The aim of this study was to confirm the efficacy of 6-month domain-based language training of school-age, severe-to-profound hearing-impaired children. Methods: We conducted a controlled before-after study involving 728 severe-to-profound prelingual hearing-impaired children, including an intervention group (n = 60), control group (n = 30), and baseline study group (n = 638). Language scores of the participants and questionnaires to the caregivers/therapists were compared before and after the intervention. Average monthly increase in each language score of the control group and baseline study group were compared with those of the intervention group. Results: Language scores and the results of the questionnaire of the intervention group showed a significant improvement (P < .05). The average monthly language growth of the intervention group was twice that of the control group and 3 to 4 times that of the baseline study group (P < .05). The effect size was largest in communication (1.914), followed by syntax (0.931). Conclusion: Domain-based language training improved the language development and daily communication of hearing-impaired children without any adverse effects. C1 [Sugaya, Akiko; Fukushima, Kunihiro; Kasai, Norio; Nishizaki, Kazunori] Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Otolaryngol Head & Neck Surg, Okayama 7008558, Japan. [Kasai, Norio] Natl Sanat Oku Komyo En, Dept Otolaryngol, Okayama, Japan. [Ojima, Toshiyuki] Hamamatsu Univ, Sch Med, Dept Community Hlth & Prevent Med, Shizuoka, Japan. [Takahashi, Goro] Hamamatsu Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, Shizuoka, Japan. [Nakagawa, Takashi] Fukuoka Univ, Sch Med, Dept Otolaryngol, Fukuoka 81401, Japan. [Murai, Seiko] Morioka Municipal Hosp, Dept Otolaryngol, Morioka, Iwate, Japan. [Nakajima, Yasoichi] Natl Rehabil Ctr Persons Disabil, Saitama, Japan. RP Nishizaki, K (reprint author), Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Otolaryngol Head & Neck Surg, Kita Ku, 2-5-1 Shikata Cho, Okayama 7008558, Japan. EM kuni@cc.okayama-u.ac.jp FU RSCD project; Ministry of Health, Labour and Welfare of Japan FX The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by the RSCD project, funded by the Ministry of Health, Labour and Welfare of Japan. CR Baudonck N, 2011, INT J AUDIOL, V50, P912, DOI 10.3109/14992027.2011.605803 Bishop DVM, 2006, INT J LANG COMM DIS, V41, P19, DOI 10.1080/13682820500144000 Boyle J, 2007, HEALTH TECHNOL ASSES, V11, P1 Camarata S, 2009, 1 LANGUAGE, V29, P51 Cohen W, 2005, J SPEECH LANG HEAR R, V48, P715, DOI 10.1044/1092-4388(2005/049) Ebbels SH, 2007, J SPEECH LANG HEAR R, V50, P1330, DOI 10.1044/1092-4388(2007/093) Fitzpatrick E, 2007, EAR HEARING, V28, P842 Fitzpatrick EM, 2011, EAR HEARING, V32, P605, DOI 10.1097/AUD.0b013e31821348ae Fujiyoshi Akie, 2012, Ann Otol Rhinol Laryngol Suppl, V202, P28 Fukushima Kunihiro, 2012, Ann Otol Rhinol Laryngol Suppl, V202, P3 Gillarn RB, 2008, J SPEECH LANG HEAR R, V51, P97, DOI 10.1044/1092-4388(2008/007) Kasai Norio, 2012, Ann Otol Rhinol Laryngol Suppl, V202, P16 Koren R, 2005, ARCH CLIN NEUROPSYCH, V20, P267 Nakajima R, 1997, JPN J LOGOP PHONIATR, V38, P161 Pimperton H, 2012, ARCH DIS CHILD, V97, P648, DOI 10.1136/archdischild-2011-301501 Satake T, 1996, MANUAL TEST QUERY AN Sininger YS, 2010, EAR HEARING, V31, P166, DOI 10.1097/AUD.0b013e3181c8e7b6 Sugaya Akiko, 2012, Ann Otol Rhinol Laryngol Suppl, V202, P21 Sugishita Syuuhei, 2012, Ann Otol Rhinol Laryngol Suppl, V202, P35 Tomblin B, 2007, EAR HEARING, V28, P715 Ueno K, 2002, PICTURE VOCABULARY T Uno A, 2005, JAPAN J LOGOPEDICS P, V46, P185 Yamada A, 2007, PSYCHIAT CLIN NEUROS, V61, P651, DOI 10.1111/j.1440-1819.2007.01736.x NR 23 TC 0 Z9 0 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD JUL PY 2014 VL 123 IS 7 BP 500 EP 508 DI 10.1177/0003489414525023 PG 9 WC Otorhinolaryngology SC Otorhinolaryngology GA AJ8RN UT WOS:000337974800008 PM 24627405 ER PT J AU Ueno, T Endo, K Kondo, S Wakisaka, N Murono, S Ito, M Yoshizaki, T AF Ueno, Takayoshi Endo, Kazuhira Kondo, Satoru Wakisaka, Naohiro Murono, Shigeyuki Ito, Makoto Yoshizaki, Tomokazu TI Factors Affecting Outcomes of Alternating Chemoradiotherapy for Nasopharyngeal Cancer SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE 5-fluorouracil; alternating chemoradiotherapy; cisplatin; nasopharyngeal cancer; progression-free survival; weight loss ID ADJUVANT CHEMOTHERAPY; RADIATION-THERAPY; CONCURRENT CHEMORADIOTHERAPY; PHASE-III; RANDOMIZED-TRIAL; CARCINOMA; RADIOTHERAPY; SURVIVAL; 5-FLUOROURACIL; MANAGEMENT AB Objective: Nasopharyngeal cancer (NPC) is radiosensitive and chemosensitive. We evaluated the efficacy of alternating chemoradiotherapy in patients with advanced NPC. Methods: Alternating chemoradiotherapy was initiated in 30 patients with NPC, and 27 patients with cancer stages II (n = 6), III (n = 8), IVA (n = 9), and IVB (n = 4) were retrospectively analyzed. Chemotherapy was initially administered followed by radiotherapy, and chemotherapy, radiotherapy, and chemotherapy were alternately administered. Of the 27 patients, 22 patients received cisplatin (50 mg/m(2)/day, days 6 and 7) and 5-fluorouracil (5-FU; 800 mg/m(2)/day, days 1-5), whereas 5 patients received carboplatin (AUC 4-5, day 6) and 5-FU. Results: Of the 27 patients, 19 (70%) received 3 chemotherapy courses. The total duration of alternating chemoradiotherapy was 81 to 101 days (median, 90 days). At a median follow-up of 53 months, the 5-year progression-free survival (PFS) was 71%. Multivariate analysis showed that weight loss and the number of chemotherapy courses had a significant effect on PFS. Conclusion: Alternating chemoradiotherapy led to similar or higher survival rates compared with concurrent chemoradiotherapy, which was characterized by good compliance and adaptable intensity. C1 [Ueno, Takayoshi; Endo, Kazuhira; Kondo, Satoru; Wakisaka, Naohiro; Murono, Shigeyuki; Ito, Makoto; Yoshizaki, Tomokazu] Kanazawa Univ, Grad Sch Med Sci, Div Otolaryngol Head & Neck Surg, Kanazawa, Ishikawa 9208641, Japan. RP Yoshizaki, T (reprint author), Kanazawa Univ, Grad Sch Med Sci, Div Otolaryngol, 13-1 Takara Machi, Kanazawa, Ishikawa 9208641, Japan. EM tomoy@med.kanazawa-u.ac.jp CR Al-Sarraf M, 1998, J CLIN ONCOL, V16, P1310 Beaver ME, 2001, OTOLARYNG HEAD NECK, V125, P645, DOI 10.1067/mhn.2001.120428 Cancer Therapy Evaluation Program, 2003, COMM TERM CRIT ADV E Chen Y, 2008, INT J RADIAT ONCOL, V71, P1356, DOI [10.1016/j.ijrobp.2007.12.028, 10.1016/.i.ijrobp.2007.12.028] Chi KH, 2002, INT J RADIAT ONCOL, V52, P1238, DOI 10.1016/S0360-3016(01)02781-X DONALDSON SS, 1979, CANCER, V43, P2036, DOI 10.1002/1097-0142(197905)43:5+<2036::AID-CNCR2820430712>3.0.CO;2-7 Fuwa N, 2001, JPN J CLIN ONCOL, V31, P589, DOI 10.1093/jjco/hye135 Fuwa N, 2007, ORAL ONCOL, V43, P948, DOI 10.1016/j.oratoncotogy.2006.11.003 Geara FB, 1997, RADIOTHER ONCOL, V43, P53, DOI 10.1016/S0167-8140(97)01914-2 Ho J, 1978, INT J RADIAT ONCOL, V4, P183 HOPPE RT, 1976, CANCER, V37, P2605, DOI 10.1002/1097-0142(197606)37:6<2605::AID-CNCR2820370607>3.0.CO;2-W Lee AWM, 2005, J CLIN ONCOL, V23, P6966, DOI 10.1200/JCO.2004.00.7542 Lee AWM, 2011, EUR J CANCER, V47, P656, DOI 10.1016/j.ejca.2010.10.026 Lee AWM, 2012, SEMIN RADIAT ONCOL, V22, P233, DOI 10.1016/j.semradonc.2012.03.008 Lin JC, 2003, J CLIN ONCOL, V21, P631, DOI 10.1200/JCO.2003.06.158 MARCIAL VA, 1980, INT J RADIAT ONCOL, V6, P409 Murono S, 1999, HISTOPATHOLOGY, V34, P432 PEREZ CA, 1969, CANCER, V24, P1, DOI 10.1002/1097-0142(196907)24:1<1::AID-CNCR2820240102>3.0.CO;2-H QIN DX, 1988, CANCER, V61, P1117, DOI 10.1002/1097-0142(19880315)61:6<1117::AID-CNCR2820610611>3.0.CO;2-J Rosenthal David I, 2007, J Support Oncol, V5, P23 ROSSI A, 1988, J CLIN ONCOL, V6, P1401 Sanada K, 1987, CANC INCIDENCE 5 CON, V7, P382 Suntharalingam Mohan, 2001, Cancer, V91, P548, DOI 10.1002/1097-0142(20010201)91:3<548::AID-CNCR1033>3.0.CO;2-A WANG CC, 1971, CANCER, V28, P566, DOI 10.1002/1097-0142(197109)28:3<566::AID-CNCR2820280306>3.0.CO;2-A WANG DC, 1988, CANCER, V61, P2338, DOI 10.1002/1097-0142(19880601)61:11<2338::AID-CNCR2820611131>3.0.CO;2-O Wee J, 2005, J CLIN ONCOL, V23, P6730, DOI 10.1200/JCO.2005.16.790 Yoshizaki T, 2013, CANCER LETT, V337, P1, DOI 10.1016/j.canlet.2013.05.018 NR 27 TC 1 Z9 1 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD JUL PY 2014 VL 123 IS 7 BP 509 EP 516 DI 10.1177/0003489414525122 PG 8 WC Otorhinolaryngology SC Otorhinolaryngology GA AJ8RN UT WOS:000337974800009 PM 24634152 ER PT J AU Lim, YH Choi, J Kim, KR Shin, J Hwang, KG Ryu, S Cho, SH AF Lim, Young-Hyo Choi, Jihye Kim, Kyung Rae Shin, Jinho Hwang, Kyung Gyun Ryu, Seungho Cho, Seok Hyun TI Sex-Specific Characteristics of Anthropometry in Patients With Obstructive Sleep Apnea: Neck Circumference and Waist-Hip Ratio SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE anthropometry; gender; neck; obesity; obstructive sleep apnea ID POSITIVE AIRWAY PRESSURE; CARDIOVASCULAR OUTCOMES; METABOLIC SYNDROME; CLINICAL-FEATURES; FAT DISTRIBUTION; PREDICTIVE-VALUE; HEART HEALTH; RISK-FACTOR; SEVERITY; OBESITY AB Objective: This study aimed to investigate the sex-specific effects of anthropometric profiles on the occurrence and severity of obstructive sleep apnea (OSA). Methods: We evaluated 151 patients with suspected OSA undergoing polysomnography and anthropometric measurements such as body mass index (BMI), neck and waist circumference (NC and WC), and waist-hip ratio (WHR). Results: In men, NC (P = .006), WC (P = .035), and WHR (P = .003) were significantly increased in OSA and all were significantly correlated with apnea hypopnea index (AHI). However, in female OSA patients, BMI (P = .05), WC (P = .008), and WHR (P = .001) were elevated, but only WHR was significantly correlated with AHI. Correlation analyses showed significant correlations between NC and other anthropometric indexes in men but not in women. The receiver operating characteristic curves revealed that NC and WHR in men, and WHR in women, were significant in both model 1 (AHI = 5) and model 2 (AHI = 15). Conclusion: Waist-hip ratio is the most reliable correlate of OSA in both sexes. Neck circumference is an independent risk factor for male, but not for female, OSA patients. These different aspects of obesity may contribute to the pathogenesis of OSA and provide helpful guidance in the screening of OSA. C1 [Lim, Young-Hyo; Shin, Jinho] Hanyang Univ, Coll Med, Dept Internal Med, Div Cardiol, Seoul 133792, South Korea. [Choi, Jihye; Kim, Kyung Rae; Cho, Seok Hyun] Hanyang Univ, Coll Med, Dept Otorhinolaryngol Head & Neck Surg, Seoul 133792, South Korea. [Hwang, Kyung Gyun] Hanyang Univ, Coll Med, Dept Dent, Seoul 133792, South Korea. [Ryu, Seungho] Sungkyunkwan Univ, Sch Med, Kangbuk Samsung Hosp, Dept Occupat & Environm Med, Seoul, South Korea. RP Cho, SH (reprint author), Hanyang Univ, Coll Med, Dept Otorhinolaryngol Head & Neck Surg, 222 Wangshimniro, Seoul 133792, South Korea. EM shcho@hanyang.ac.kr CR Berry RB, 2012, J CLIN SLEEP MED, V8, P597, DOI 10.5664/jcsm.2172 Bouloukaki I, 2011, SLEEP BREATH, V15, P657, DOI 10.1007/s11325-010-0416-6 Chung S, 2007, SLEEP, V30, P997 Coughlin SR, 2004, EUR HEART J, V25, P735, DOI 10.1016/j.ehj.2004.02.021 Davidson TM, 2008, LARYNGOSCOPE, V118, P339, DOI 10.1097/MLG.0b013e3181587d7c Deegan PC, 1996, EUR RESPIR J, V9, P117, DOI 10.1183/09031936.96.09010117 Doherty LS, 2005, CHEST, V127, P2076, DOI 10.1378/chest.127.6.2076 HOFFSTEIN V, 1993, SLEEP, V16, P118 Hora F, 2007, RESPIRATION, V74, P517, DOI 10.1159/000097790 Ip Mary SM, 1998, CHIN MED J, V111, P257 Kawaguchi Y, 2011, OBESITY, V19, P276, DOI 10.1038/oby.2010.170 Levy P, 2009, EUR RESPIR J, V34, P243, DOI 10.1183/09031936.00166808 Marin JM, 2005, LANCET, V365, P1046, DOI 10.1016/S0140-6736(05)71141-7 Marshall NS, 2008, SLEEP, V31, P1079 Martinez-Rivera C, 2008, OBESITY, V16, P113, DOI 10.1038/oby.2007.20 Nagayoshi M, 2011, SLEEP BREATH, V15, P63, DOI 10.1007/s11325-009-0319-6 Namysłowski G, 2005, J Physiol Pharmacol, V56 Suppl 6, P59 Onat A, 2009, CLIN NUTR, V28, P46, DOI 10.1016/j.clnu.2008.10.006 PETER JH, 1995, EUR RESPIR J, V8, P1572 Pinto JA, 2011, BRAZ J OTORHINOLAR, V77, P516, DOI 10.1590/S1808-86942011000400017 Seicean S, 2008, DIABETES CARE, V31, P1001, DOI 10.2337/dc07-2003 Shinohara E, 1997, J INTERN MED, V241, P11, DOI 10.1046/j.1365-2796.1997.63889000.x Simpson L, 2010, SLEEP, V33, P467 Soylu AC, 2012, SLEEP BREATH, V16, P1151, DOI 10.1007/s11325-011-0623-9 Subramanian S, 2012, SLEEP BREATH, V16, P1091, DOI 10.1007/s11325-011-0607-9 Tuomilehto H, 2013, SLEEP MED REV, V17, P321, DOI 10.1016/j.smrv.2012.08.002 Vgontzas Alexandros N., 2008, Archives of Physiology and Biochemistry, V114, P211, DOI 10.1080/13813450802364627 Villaneuva ATC, 2005, SLEEP MED REV, V9, P419, DOI 10.1016/j.smrv.2005.04.005 West SD, 2006, THORAX, V61, P945, DOI 10.1136/thx.2005.057745 Whittle AT, 1999, THORAX, V54, P323 Young T, 2008, SLEEP, V31, P1071 YOUNG T, 1993, NEW ENGL J MED, V328, P1230, DOI 10.1056/NEJM199304293281704 Young T, 2002, ARCH INTERN MED, V162, P893, DOI 10.1001/archinte.162.8.893 NR 33 TC 1 Z9 1 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD JUL PY 2014 VL 123 IS 7 BP 517 EP 523 DI 10.1177/0003489414526134 PG 7 WC Otorhinolaryngology SC Otorhinolaryngology GA AJ8RN UT WOS:000337974800010 PM 24668052 ER PT J AU Mostafa, HS Fawzy, TO Jabri, WR Ayad, E AF Mostafa, Hany S. Fawzy, Tamer O. Jabri, Waleed R. Ayad, Essam TI Lymphatic Obstruction: A Novel Etiologic Factor in the Formation of Antrochoanal Polyps SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE acinous mucous gland; antrochoanal polyp; endoscopic sinus surgery; functional endoscopic sinus surgery; Killian polyp; lymphatic capillary; LYVE-1; maxillary sinus; maxillary sinusitis mucosal biopsy; nasal polyp ID PARANASAL SINUSES; CHOANAL POLYP; NASAL POLYPS; CHILDREN; ORIGIN AB Objectives: Antrochoanal polyps (ACPs) originate from the inner wall of the maxillary sinus and either pass through the natural sinus ostia or cause pressure-induced destruction of the medial sinus wall. Eventually, they extend into the choanae and nasopharynx. Most authors who have studied the microstructure of ACPs, including the component stromal cells and surface epithelium, have not examined the transitional area between the sinus mucosa and the pedicle of the polyp. No explanation has been given for the absence of a cystic intrasinus portion of the polyp, in many cases refuting the therapy (most accepted) that polyps are caused by a mucous gland with a blocked acinus. We noted during endoscopic removal of the ACPs that the antral part of the polyp was cystic in only 5% of patients, and polypoid in 95%. The cystic intrasinus portion of the polyp is a cornerstone of the pathophysiology of ACPs, whether caused by inflammation, cicatrization, or allergy. This finding prompted us to examine the transitional area between the sinus mucosa and the pedicle of the polyp to verify the possibility that lymphatic obstruction-whether primary (areas of higher tissue pressure) or secondary (cicatrization or inflammation)-could be an etiologic factor in the formation of ACPs. Methods: The study material consisted of 25 ACPs and 25 chronic maxillary sinusitis mucosal biopsy specimens (control group). The detection of lymphatic vessels was based on the identification of lymph vessel endothelial hyaluronic acid receptor 1 (LYVE-1) in the endothelial cells of the lymphatic capillaries. This was the first lymph-specific hyaluronic acid receptor to be characterized, and is a uniquely powerful marker for lymph vessels, differentiating them from (blood) capillaries. Results: The density of the lymphatic vessels was marked in 22 of the 25 ACP specimens, ie, 88% of the ACP cases, compared with 16% of the control group. Conclusions: This study resulted in two main findings. The first was the absence of intramaxillary cysts in the ACPs in 23 cases (92%). The second was the markedly high density of lymphatic vessels in the transitional area between the sinus mucosa and the pedicle of the ACPs, in comparison with the density in the control group. These two findings refute the "blocked acinus theory" and indicate that lymphatic obstruction, whether primary or secondary to chronic sinus infection, might play a leading role in the formation and further growth of ACPs. C1 [Mostafa, Hany S.; Fawzy, Tamer O.; Jabri, Waleed R.] Fayoum Univ, Fac Med, Dept Otolaryngol, Al Fayoum 12411, Egypt. [Ayad, Essam] Cairo Univ, Fac Med, Dept Histopathol, Cairo, Egypt. RP Fawzy, TO (reprint author), Fayoum Univ, Fac Med, Dept Otolaryngol, 197B 26 July St, Al Fayoum 12411, Egypt. CR Aktas Davut, 1998, Rhinology (Utrecht), V36, P81 Basak S, 1998, INT J PEDIATR OTORHI, V46, P197, DOI 10.1016/S0165-5876(98)00160-8 BERG O, 1988, ARCH OTOLARYNGOL, V114, P1270 CHEN JM, 1989, J OTOLARYNGOL, V18, P168 Cook PR, 1993, ENT-EAR NOSE THROAT, V72, P404 Cook P R, 1993, Ear Nose Throat J, V72, P401 Fang SY, 2000, ANN OTO RHINOL LARYN, V109, P267 HECK WE, 1950, AMA ARCH OTOLARYNGOL, V52, P538 Hosemann W., 1998, Rhinology (Utrecht), V36, P50 HOSEMANN W, 1991, HNO, V39, P111 HOSEMANN W, 1991, EUR ARCH OTO-RHINO-L, V248, P390, DOI 10.1007/BF01463560 Kamel R., 1990, ARCH OTOLARYNGOL, V116, P842 Killian G, 1906, LANCET, V2, P81 Kim TH, 2007, LARYNGOSCOPE, V117, P442, DOI 10.1097/MLG.0b013e31802c93b2 Kubo J., 1909, ARCH LARYNGOL RHINOL, V21, P81 Larsen K, 2002, ACTA OTO-LARYNGOL, V122, P179, DOI 10.1080/00016480252814199 LOURY MC, 1993, SOUTHERN MED J, V86, P18 MILLS C P, 1959, J Laryngol Otol, V73, P324, DOI 10.1017/S0022215100055365 MIN YG, 1995, ACTA OTO-LARYNGOL, V115, P543, DOI 10.3109/00016489509139364 Orvidas LJ, 2001, AM J RHINOL, V15, P321 Ozcan C, 2005, EUR ARCH OTO-RHINO-L, V262, P55, DOI 10.1007/s00405-003-0729-1 RYAN RE, 1979, J OTOLARYNGOL, V8, P344 Skladzien J, 2001, AURIS NASUS LARYNX, V28, P137, DOI 10.1016/S0385-8146(00)00108-5 Skladzien J, 1993, RIV ITAL OTORINOLARY, V13, P183 TOS M, 1977, Rhinology (Utrecht), V15, P87 VAN ALYEA O E, 1956, Ann Otol Rhinol Laryngol, V65, P714 WEISSKOPF A, 1959, Ann Otol Rhinol Laryngol, V68, P509 Woolley AL, 1996, AM J OTOLARYNG, V17, P368, DOI 10.1016/S0196-0709(96)90068-X NR 28 TC 0 Z9 0 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD JUN PY 2014 VL 123 IS 6 BP 381 EP 386 DI 10.1177/0003489414522973 PG 6 WC Otorhinolaryngology SC Otorhinolaryngology GA AJ8RH UT WOS:000337974100001 PM 24595626 ER PT J AU Novakovic, D D'Elia, J Branski, RC Blitzer, A AF Novakovic, Daniel D'Elia, Joanna Branski, Ryan C. Blitzer, Andrew TI The Effect of Different Angiolytic Lasers on Resolution of Subepithelial Mucosal Hematoma in an Animal Model SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE KTP; laser; larynx; vocal cord; vocal fold; hemorrhage; hematoma; varix; ectasia ID TRUE VOCAL FOLD; MICROVASCULAR LESIONS; ECTASIAS; VARICES AB Objective: Vocal fold hematoma is traditionally managed with a period of voice rest, in the order of weeks, to allow natural resolution. This study is designed to examine the efficacy and safety of a number of hemoglobin-avid (vascular) lasers when used in the setting of acute vocal fold hematoma. Methods: Venous blood drawn from 4 white rabbits was used to create an array of subepithelial hematomas in the buccal cavities of each animal. Laser energy from 1 of 3 different lasers (532-nm pulsed potassium titanyl phosphate [KTP], 532-nm diode KTP, and 940-nm diode laser) was applied to each of the test hematomas at varying energy levels. Hematoma sites were photographed at days 0, 1, 5, 7, 9, and 12. Two animals were sacrificed on day 7 and the remainder on day 12. Histological evaluation of collateral tissue damage and residual hematoma was performed on biopsy specimens. Results: Macroscopic and microscopic ulceration at laser-treated sites was mostly resolved by day 7. Inflammatory cell infiltrate was present in laser-treated and hematoma-only sites. Laser-treated samples showed alterations in vascularity. Conclusion: Hemoglobin-avid lasers may be beneficial in accelerating subepithelial hematoma resolution with a favorable tissue damage profile. C1 [Novakovic, Daniel] Univ Sydney, Dept Otolaryngol Head & Neck Surg, St Leonards, NSW 2065, Australia. [D'Elia, Joanna; Blitzer, Andrew] New York Ctr Voice & Swallowing Disorders, New York, NY USA. [Branski, Ryan C.] NYU, Sch Med, New York Univ Voice Ctr, Dept Otolaryngol Head & Neck Surg, New York, NY USA. RP Novakovic, D (reprint author), Univ Sydney, Dept Otolaryngol Head & Neck Surg, Suite 1,Level 1,66 Pacific Highway, St Leonards, NSW 2065, Australia. EM daniel.novakovic@sydney.edu.au CR Abitbol J, 1988, J VOICE, V2, P261, DOI 10.1016/S0892-1997(88)80084-5 Broadhurst MS, 2007, LARYNGOSCOPE, V117, P220, DOI 10.1097/mlg.0b013e31802b5c1c Cassuto D A, 2000, J Cutan Laser Ther, V2, P141, DOI 10.1080/14628830050516399 Franco RA, 2002, ANN OTO RHINOL LARYN, V111, P486 Hochman I, 1999, ANN OTO RHINOL LARYN, V108, P10 Hsiung MW, 2003, ANN OTO RHINOL LARYN, V112, P534 Mallur PS, 2009, LARYNGOSCOPE, V119, P2008, DOI 10.1002/lary.20567 Mallur PS, 2011, LARYNGOSCOPE, V121, P327, DOI 10.1002/lary.21284 Niamtu III J, 2001, AM J COSMET SURG, V18, P71 Postma GN, 1998, ANN OTO RHINOL LARYN, V107, P472 Spiegel J R, 1996, Ear Nose Throat J, V75, P784 Tierney E, 2009, LASER SURG MED, V41, P555, DOI 10.1002/lsm.20811 Zeitels SM, 2006, ANN OTO RHINOL LARYN, V115, P571 Zeitels SM, 1996, LARYNGOSCOPE, V106, P545, DOI 10.1097/00005537-199605000-00006 NR 14 TC 0 Z9 0 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD JUN PY 2014 VL 123 IS 6 BP 387 EP 394 DI 10.1177/0003489414526688 PG 8 WC Otorhinolaryngology SC Otorhinolaryngology GA AJ8RH UT WOS:000337974100002 PM 24671546 ER PT J AU Kim, MB Chung, WH Choi, J Hong, SH Cho, YS Park, G Lee, S AF Kim, Min-Beom Chung, Won-Ho Choi, Jeesun Hong, Sung Hwa Cho, Yang-Sun Park, Gyuseok Lee, Sangmin TI Effect of a Bluetooth-Implemented Hearing Aid on Speech Recognition Performance: Subjective and Objective Measurement SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE Bluetooth; hearing aid; wireless; noise; speech intelligibility AB Objectives: The object was to evaluate speech perception improvement through Bluetooth-implemented hearing aids in hearing-impaired adults. Methods: Thirty subjects with bilateral symmetric moderate sensorineural hearing loss participated in this study. A Bluetooth-implemented hearing aid was fitted unilaterally in all study subjects. Objective speech recognition score and subjective satisfaction were measured with a Bluetooth-implemented hearing aid to replace the acoustic connection from either a cellular phone or a loudspeaker system. In each system, participants were assigned to 4 conditions: wireless speech signal transmission into hearing aid (wireless mode) in quiet or noisy environment and conventional speech signal transmission using external microphone of hearing aid (conventional mode) in quiet or noisy environment. Also, participants completed questionnaires to investigate subjective satisfaction. Results: Both cellular phone and loudspeaker system situation, participants showed improvements in sentence and word recognition scores with wireless mode compared to conventional mode in both quiet and noise conditions (P < .001). Participants also reported subjective improvements, including better sound quality, less noise interference, and better accuracy naturalness, when using the wireless mode (P < .001). Conclusions: Bluetooth-implemented hearing aids helped to improve subjective and objective speech recognition performances in quiet and noisy environments during the use of electronic audio devices. C1 [Kim, Min-Beom] Sungkyunkwan Univ, Sch Med, Kangbuk Samsung Hosp, Dept Otorhinolaryngol Head & Neck Surg, Seoul, South Korea. [Chung, Won-Ho; Choi, Jeesun; Hong, Sung Hwa; Cho, Yang-Sun] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Otorhinolaryngol Head & Neck Surg, Seoul, South Korea. [Park, Gyuseok; Lee, Sangmin] Inha Univ, Dept Elect Engn, Inchon, South Korea. RP Chung, WH (reprint author), Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Otorhinolaryngol Head & Neck Surg, 50 Irwon Dong, Seoul, South Korea. EM whchung@skku.edu RI Cho, Yang Sun/F-4611-2014 FU Ministry of Health & Welfare of the government of the Republic of Korea [A091039] FX The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This study was supported by a research grant (A091039) from the Ministry of Health & Welfare of the government of the Republic of Korea. CR Byrne D, 2001, J Am Acad Audiol, V12, P37 CASHMAN MZ, 1982, J OTOLARYNGOL, V11, P239 Chung King, 2004, Trends Amplif, V8, P125, DOI 10.1177/108471380400800402 Dawes P, 2011, EAR HEARING, V32, P767, DOI 10.1097/AUD.0b013e3182251a0e Kochkin S., 2000, HEARING J, V53, P34 Kochkin SMV, 2005, HEARING J, V58, P30 Kreisman BM, 2010, TRENDS AMPLIF, V14, P3, DOI 10.1177/1084713810364396 Latzel M, 2001, SCAND AUDIOL, V30, P69, DOI 10.1080/010503901300007100 Lee J, 2008, AUDIOLOGY, V4, P161 Lee J, 2008, AUDIOLOGY, V4, P178 Levitt H, 2007, HEAR J, V60, P20 Levitt H, 2001, J REHABIL RES DEV, V38, P111 Picou EM, 2011, EAR HEARING, V32, P209, DOI 10.1097/AUD.0b013e3181f53737 Sherbecoe RL, 2002, EAR HEARING, V23, P385, DOI 10.1097/01.AUD.0000034412.18975.EB Tyler RS, 2011, ASHA LEADER 0315 Vilet DV, 2005, J AM ACAD AUDIOL, V16, P410 NR 16 TC 0 Z9 0 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD JUN PY 2014 VL 123 IS 6 BP 395 EP 401 DI 10.1177/0003489414526847 PG 7 WC Otorhinolaryngology SC Otorhinolaryngology GA AJ8RH UT WOS:000337974100003 PM 24687593 ER PT J AU Davids, T Muller, S Wise, JC Johns, MM Klein, A AF Davids, Taryn Muller, Susan Wise, Justin C. Johns, Michael M., III Klein, Adam TI Laryngeal Papillomatosis Associated Dysplasia in the Adult Population: An Update on Prevalence and HPV Subtyping SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE laryngeal papillomatosis; recurrent laryngeal papillomatosis; human papilloma virus; Laryngeal neoplasms; dysplasia ID RECURRENT RESPIRATORY PAPILLOMATOSIS; PREMALIGNANT LESIONS; RISK AB Objectives: The objectives were to determine the prevalence of laryngeal dysplasia and associated human papilloma virus (HPV) subtypes in adult patients, 18 years or older, suffering from laryngeal papillomatosis at a tertiary care institution. Study Design: Retrospective cohort study. Methods: Patients with biopsy proven laryngeal papillomatosis were identified via chart review. All available pathology specimens were reviewed by a dedicated head and neck pathologist to confirm/refute the diagnosis of laryngeal dysplasia, and grade the level of dysplasia. Interrater agreement was compared using cross-tabulation methods. Specimens identified to be positive for dysplasia underwent further testing via in situ hybridization for low-risk (6/11) or high-risk (16/18) HPV subtypes. Results: Of the 85 subjects identified to have laryngeal papillomatosis, 24(28%) demonstrated laryngeal dysplasia. There was good interrater agreement on the presence of dysplasia; however, there was only fair agreement on the grade of dysplasia. Of the pathology specimens tested for HPV subtype, the majority of patients (62%) were positive for HPV 6/11, including all high-grade dysplasia patients. Three (12%) dysplasia specimens were negative for both high-and low-risk HPV subtypes. Conclusions: We found a 28% prevalence of dysplasia in our patient population with the majority of patients positive for low-risk HPV subtypes indicating that high-risk HPV subtypes do not predispose laryngeal papilloma patients to dysplasia. C1 [Davids, Taryn] Univ Toronto, Dept Otolaryngol Head & Neck Surg, Toronto, ON, Canada. [Muller, Susan] Emory Univ, Sch Med, Dept Pathol & Lab Med, Winship Canc Inst,Dept Otolaryngol Head & Neck Su, Atlanta, GA 30322 USA. [Wise, Justin C.] Oglethorpe Univ, Dept Psychol, Atlanta, GA USA. [Johns, Michael M., III; Klein, Adam] Emory Univ, Sch Med, Dept Otolaryngol, Emory Voice Ctr, Atlanta, GA USA. RP Davids, T (reprint author), Univ Toronto, Dept Otolaryngol Head & Neck Surg, 589 Davis Dr,Ste 104, Newmarket, ON L3Y 2P6, Canada. EM taryndavids@hotmail.com CR Barnes L, 2005, WORLD HLTH ORG CLASS, P144 Blumin JH, 2009, ANN OTO RHINOL LARYN, V118, P481 Fleskens SAJHM, 2011, MODERN PATHOL, V24, P892, DOI 10.1038/modpathol.2011.50 Go C, 2003, ANN OTO RHINOL LARYN, V112, P298 Hall JE, 2011, OTOLARYNG HEAD NECK, V144, P252, DOI 10.1177/0194599810391626 Lindeberg H, 1997, CLIN OTOLARYNGOL, V22, P382, DOI 10.1046/j.1365-2273.1997.00005.x McLaren KM, 2000, HISTOPATHOLOGY, V37, P460, DOI 10.1046/j.1365-2559.2000.00998.x Sarioglu Sulen, 2010, Head Neck Pathol, V4, P276, DOI 10.1007/s12105-010-0208-0 Waters HH, 2010, LARYNGOSCOPE, V120, pS201, DOI 10.1002/lary.21668 Weller MD, 2010, CLIN OTOLARYNGOL, V35, P364, DOI 10.1111/j.1749-4486.2010.02181.x NR 10 TC 0 Z9 0 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD JUN PY 2014 VL 123 IS 6 BP 402 EP 408 DI 10.1177/0003489414526848 PG 7 WC Otorhinolaryngology SC Otorhinolaryngology GA AJ8RH UT WOS:000337974100004 PM 24690979 ER PT J AU Kania, R Hammami, H Verillaud, B Blancal, JP Sauvaget, E Tran, H Leclerc, N Altabaa, K Herman, P Pons, Y AF Kania, Romain Hammami, Hassene Verillaud, Benjamin Blancal, Jean-Philippe Sauvaget, Elisabeth Tran, Hugo Leclerc, Nicolas Altabaa, Khaled Herman, Philippe Pons, Yoann TI Minimally Invasive Video-Assisted Thyroidectomy: Tips and Pearls for the Surgical Technique SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE minimally invasive video-assisted thyroidectomy; surgical technique ID EXPANDED INDICATIONS AB Background: The objectives of this study were first to show principles of the minimally invasive video-assisted thyroidectomy (MIVAT), based on a video highlighting critical steps, and second to discuss tips and pearls to assist surgical teams that would like to start using this technique. Methods: Based on a video, we described tips and pearls of a MIVAT. Results: MIVAT includes 5 main steps: (1) skin incision and identification of the common carotid artery, (2) dissection and ligation of the upper pedicle, (3) identification of the inferior laryngeal nerve and parathyroid glands, (4) isthmectomy and lobe extraction, and (5) closure. Discussion: Coordination between the surgeon and the 2 assistants is of paramount importance for the performance of MIVAT. Appropriate material is also required. The magnification and tissue contrast emphasizes the identification of the vessels, the superior and inferior laryngeal nerves, and parathyroid glands, on a large-view screen. C1 [Kania, Romain; Hammami, Hassene; Verillaud, Benjamin; Blancal, Jean-Philippe; Sauvaget, Elisabeth; Tran, Hugo; Leclerc, Nicolas; Altabaa, Khaled; Herman, Philippe; Pons, Yoann] Hop Lariboisiere, Dept Head & Neck Surg, F-75010 Paris, France. RP Pons, Y (reprint author), Hop Lariboisiere, Serv ORL Chirurg Cervicofaciale, 2 Rue Ambroise Pare, F-75010 Paris, France. EM pons.yoann@gmail.com CR Alesina PF, 2011, SURGERY, V149, P556, DOI 10.1016/j.surg.2010.11.018 Del Rio P, 2010, LANGENBECK ARCH SURG, V395, P323, DOI 10.1007/s00423-009-0589-2 El-Labban Gouda M, 2009, J Minim Access Surg, V5, P97, DOI 10.4103/0972-9941.59307 Gagner M, 1996, BRIT J SURG, V83, P875, DOI 10.1002/bjs.1800830656 Higgins TS, 2011, LARYNGOSCOPE, V121, P1009, DOI 10.1002/lary.21578 Huscher CSG, 1997, SURG ENDOSC-ULTRAS, V11, P877, DOI 10.1007/s004649900476 Kania R E, 2009, Ann Otolaryngol Chir Cervicofac, V126, P82, DOI 10.1016/j.aorl.2009.01.006 Kim AJ, 2011, HEAD NECK-J SCI SPEC, V33, P1557, DOI 10.1002/hed.21633 Lai SY, 2008, HEAD NECK-J SCI SPEC, V30, P1403, DOI 10.1002/hed.20883 Miccoli P, 2001, AM J SURG, V181, P567, DOI 10.1016/S0002-9610(01)00625-0 Miccoli P, 2010, SURG ENDOSC, V24, P2415, DOI 10.1007/s00464-010-0964-7 Miccoli P, 2002, WORLD J SURG, V26, P972, DOI 10.1007/s00268-002-6627-7 Miccoli P, 2010, CURR OPIN OTOLARYNGO, V18, P114, DOI 10.1097/MOO.0b013e3283378239 Minuto MN, 2012, SURG ENDOSC, V26, P818, DOI 10.1007/s00464-011-1958-9 Neidich MJ, 2012, HEAD NECK-J SCI SPEC, V34, P354, DOI 10.1002/hed.21733 Radford PD, 2011, LARYNGOSCOPE, V121, P1675, DOI 10.1002/lary.21864 Ruggieri M, 2007, BMC SURG, V25, P2 Sahm M, 2011, SURG ENDOSC, V25, P3202, DOI 10.1007/s00464-011-1693-2 Samraj K, 2007, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD006099.pub2 Terris DJ, 2006, LARYNGOSCOPE, V116, P350, DOI 10.1097/01.mlg.0000191462.58630.e4 NR 20 TC 0 Z9 0 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD JUN PY 2014 VL 123 IS 6 BP 409 EP 414 DI 10.1177/0003489414526845 PG 6 WC Otorhinolaryngology SC Otorhinolaryngology GA AJ8RH UT WOS:000337974100005 PM 24671545 ER PT J AU Brunworth, JD Mahboubi, H Garg, R Johnson, B Brandon, B Djalilian, HR AF Brunworth, Joseph D. Mahboubi, Hossein Garg, Rohit Johnson, Brandon Brandon, Bryan Djalilian, Hamid R. TI Nasopharyngeal Acid Reflux and Eustachian Tube Dysfunction in Adults SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE Eustachian tube dysfunction; laryngopharyngeal reflux; nasopharyngeal acid reflux; pH probe ID GASTROESOPHAGEAL-REFLUX; OTITIS-MEDIA; EXTRAESOPHAGEAL REFLUX; ANTIREFLUX THERAPY; CHILDREN; EAR; MANIFESTATIONS; PREVALENCE; SYMPTOMS; EXPOSURE AB Objective: This study aimed to evaluate the relationship between nasopharyngeal pH and Eustachian tube dysfunction (ETD) in adults. Study Design: Unmatched case-control study. Methods: Forty-one subjects, 20 adults with a diagnosis of ETD and 21 healthy adults as controls, were enrolled from an outpatient clinic. All subjects had a Dx-pH probe placed near the torus tubarius in the posterior nasopharynx for 24 hours. The pH values were recorded every 0.5 second. Decreases in pH were considered as reflux events if the pH dropped below 5.5. Results: The average nasopharyngeal pH value was 6.90 (range, 5.33-7.73) in the subjects with ETD and 7.07 (range, 5.99-7.94) in the controls. The difference between the 2 groups was not statistically significant (P = .30). The ETD group, on average, had a higher number of nasopharyngeal reflux events (2.3 +/- 1.6 vs 0.8 +/- 1.2, respectively; P = .002) and higher reflux finding score (3.6 +/- 2.7 vs 0.4 +/- 1.4, respectively; P < .001) than the control group. Conclusion: By using a novel pH probe that allows detection of acidity in a nonliquid environment, a comparison of nasopharyngeal pH between control patients and those with ETD was performed. Eustachian tube dysfunction was more likely to be associated with a higher number of nasopharyngeal reflux events and higher reflux finding score. Nasopharyngeal reflux may have a role in the pathogenesis of ETD. C1 [Brunworth, Joseph D.; Mahboubi, Hossein; Garg, Rohit; Johnson, Brandon; Brandon, Bryan; Djalilian, Hamid R.] Univ Calif Irvine, Dept Otolaryngol Head & Neck Surg, Div Neurotol & Skull Base Surg, Irvine, CA 92668 USA. [Djalilian, Hamid R.] Univ Calif Irvine, Dept Biomed Engn, Irvine, CA USA. RP Djalilian, HR (reprint author), Univ Calif Irvine, Dept Otolaryngol Head & Neck Surg, 101 City Dr South,Bldg 56,Suite 500, Orange, CA 92868 USA. EM hdjalili@uci.edu CR Ayazi S, 2009, J GASTROINTEST SURG, V13, P1422, DOI 10.1007/s11605-009-0915-6 Belafsky PC, 2001, LARYNGOSCOPE, V111, P1313, DOI 10.1097/00005537-200108000-00001 Brunworth JD, 2012, ANN OTO RHINOL LARYN, V121, P427 He ZP, 2007, OTOLARYNG HEAD NECK, V137, P59, DOI 10.1016/j.otohns.2007.02.002 Heavner SB, 2001, OTOLARYNG HEAD NECK, V125, P123, DOI 10.1067/mhn.2001.116448 KOUFMAN JA, 1991, LARYNGOSCOPE, V101, P1 Locke GR, 1997, GASTROENTEROLOGY, V112, P1448, DOI 10.1016/S0016-5085(97)70025-8 Loehrl TA, 2012, LARYNGOSCOPE, V122, P1425, DOI 10.1002/lary.23283 Miura MS, 2012, OTOLARYNG HEAD NECK, V146, P345, DOI 10.1177/0194599811430809 O'Reilly RC, 2008, LARYNGOSCOPE, V118, P1, DOI 10.1097/MLG.0b013e31817924a3 Park JO, 2012, OTOLARYNG HEAD NECK, V146, P92, DOI 10.1177/0194599811422014 Poelmans J, 2002, ANN OTO RHINOL LARYN, V111, P933 Schreiber S, 2009, EUR ARCH OTO-RHINO-L, V266, P17, DOI 10.1007/s00405-008-0770-1 Sone M, 2007, ACTA OTO-LARYNGOL, V127, P470, DOI 10.1080/00016480600868406 Sone M, 2007, OTOLARYNG HEAD NECK, V136, P19, DOI 10.1016/j.otohns.2006.08.024 Sone M, 2012, OTOLARYNG HEAD NECK, V146, P562, DOI 10.1177/0194599811434049 Tasker A, 2002, LANCET, V359, P493, DOI 10.1016/S0140-6736(02)07665-1 Velepic MM, 2004, ACTA OTO-LARYNGOL, V124, P914, DOI 10.1080/00016480410022499 White DR, 2002, LARYNGOSCOPE, V112, P955, DOI 10.1097/00005537-200206000-00004 Wong RKH, 2000, AM J GASTROENTEROL, V95, pS15, DOI 10.1016/S0002-9270(00)01074-1 Yazici ZM, 2008, LARYNGOSCOPE, V118, P849, DOI 10.1097/MLG.0b013e318164d0c0 NR 21 TC 0 Z9 0 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD JUN PY 2014 VL 123 IS 6 BP 415 EP 419 DI 10.1177/0003489414526689 PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA AJ8RH UT WOS:000337974100006 PM 24671547 ER PT J AU Takagi, D Nakamaru, Y Fukuda, S AF Takagi, Dai Nakamaru, Yuji Fukuda, Satoshi TI Otologic Manifestations of Immunoglobulin G4-Related Disease SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE eosinophilic otitis media; IgG4-related disease; otologic manifestations; prednisolone ID COMPLICATING AUTOIMMUNE PANCREATITIS; IGG4-RELATED DISEASE; DIAGNOSTIC-CRITERIA; SCLEROSING DISEASE; TEMPORAL BONE AB Objective: Immunoglobulin (Ig) G4-related disease is systemic, and it has been reported that patients with IgG4-related disease complain of symptoms involving numerous organs. However, there are few reports concerning the otologic manifestations of IgG4-related disease. The purpose of this study is to investigate the clinical features of the otologic manifestations in IgG4-related disease. Methods: We recruited 39 consecutive patients diagnosed with IgG4-related disease. Otologic symptoms, laboratory data, and audiogram findings were retrospectively examined. Mucosal tissues from the inferior turbinate were obtained from subjects before treatment. The serum IgG4 and eosinophil levels together with clinical features were analyzed. Results: Five of the 39 cases had some otologic symptoms. Otitis media with effusion was present in 2 patients. Sensorineural hearing loss was also present in 1 patient. Eosinophilic otitis media was present in 2 patients with bilateral rhinosinusitis and bronchial asthma, and elevated serum eosinophil levels. Oral prednisolone was effective in the treatment of IgG4-related disease. Conclusion: We revealed a new clinical entity associated with the otologic manifestations of IgG4-related disease. C1 [Takagi, Dai; Nakamaru, Yuji; Fukuda, Satoshi] Hokkaido Univ, Grad Sch Med, Dept Otolaryngol Head & Neck Surg, Sapporo, Hokkaido 0608638, Japan. RP Takagi, D (reprint author), Hokkaido Univ, Grad Sch Med, Dept Otolaryngol Head & Neck Surg, Kita Ku, North 15,West 7, Sapporo, Hokkaido 0608638, Japan. EM daitamed@huhp.hokudai.ac.jp CR Bittencourt AG, 2013, OTOL NEUROTOL, V34, pE20, DOI 10.1097/MAO.0b013e31827f1948 Cho HK, 2011, CLIN EXP OTORHINOLAR, V4, P52, DOI 10.3342/ceo.2011.4.1.52 Ghazale A, 2007, GUT, V56, P1650, DOI 10.1136/gut.2007.129833 Hamano H, 2002, LANCET, V359, P1403, DOI 10.1016/S0140-6736(02)08359-9 Iino Y, 2001, CLIN EXP ALLERGY, V31, P1135, DOI 10.1046/j.1365-2222.2001.01134.x Inoue D, 2012, INT J RHEUMATOL, V2012, DOI DOI 10.1155/2012/401890 Lindstrom KM, 2010, ACTA NEUROPATHOL, V120, P765, DOI 10.1007/s00401-010-0746-2 Masterson L, 2010, J LARYNGOL OTOL, V124, P1106, DOI 10.1017/S0022215110001143 MORGAN WS, 1953, AM J PATHOL, V29, P471 Moteki H, 2011, ACTA OTO-LARYNGOL, V131, P518, DOI 10.3109/00016489.2010.533699 Stone JH, 2012, NEW ENGL J MED, V366, P539, DOI 10.1056/NEJMra1104650 Suzuki M, 2013, LARYNGOSCOPE, V123, P829, DOI 10.1002/lary.23792 Takagi D, 2002, LARYNGOSCOPE, V112, P1684, DOI 10.1097/00005537-200209000-00029 Takeda S, 2004, NEPHROL DIAL TRANSPL, V19, P474, DOI 10.1093/ndt/gfg477 Umehara H, 2012, MOD RHEUMATOL, V22, P21, DOI 10.1007/s10165-011-0571-z Yoshimura Y, 2006, INTERNAL MED, V45, P897, DOI 10.2169/internalmedicine.45.1752 Zen Y, 2005, HUM PATHOL, V36, P710, DOI 10.1016/j.humpath.2005.05.011 NR 17 TC 3 Z9 3 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD JUN PY 2014 VL 123 IS 6 BP 420 EP 424 DI 10.1177/0003489414526844 PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA AJ8RH UT WOS:000337974100007 PM 24682733 ER PT J AU Nogueira, C Meehan, T O'Donoghue, G AF Nogueira, Claudia Meehan, Thomasina O'Donoghue, Gerard TI Refsum's Disease and Cochlear Implantation SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE Refsum's disease; cochlear implants; sensorineural deafness; hearing ID HEARING-LOSS AB Objectives: The objective was to describe a case of bilateral cochlear implantation in a 59-year-old man with hearing and visual impairment due to Refsum's disease. Method: A retrospective case review was performed. Results: After cochlear implantation, the patient demonstrated much improved audiometric performance and reported improved sound localization. Conclusions: Bilateral cochlear implantation is an important strategy in the improvement of hearing and quality of life in individuals with Refsum's disease. C1 [Nogueira, Claudia; Meehan, Thomasina; O'Donoghue, Gerard] Queens Med Ctr, Directorate Otorhinolaryngol & Head & Neck Surg, Nottingham NG7 2UH, England. RP Nogueira, C (reprint author), Queens Med Ctr, Directorate Otorhinolaryngol & Head & Neck Surg, Nottingham NG7 2UH, England. EM claudianogueira1@gmail.com CR Baldwin EJ, 2010, J NEUROL NEUROSUR PS, V81, P954, DOI 10.1136/jnnp.2008.161059 Bamiou DE, 2003, CLIN OTOLARYNGOL, V28, P227, DOI 10.1046/j.1365-2273.2003.00694.x Gloerich J, 2005, J LIPID RES, V46, P716, DOI 10.1194/jlr.M400337-JLR200 Ito J, 1997, OTOLARYNG HEAD NECK, V117, P701, DOI 10.1016/S0194-5998(97)70056-1 Jansen GA, 1997, NAT GENET, V17, P190, DOI 10.1038/ng1097-190 Oysu C, 2001, INT J PEDIATR OTORHI, V61, P129, DOI 10.1016/S0165-5876(01)00559-6 Raine C H, 2008, Cochlear Implants Int, V9, P97, DOI 10.1002/cii.356 Refsum S, 1946, ACTA PSYCHIAT SCAN S, V38, P1 van den Brink DM, 2003, AM J HUM GENET, V72, P471, DOI 10.1086/346093 NR 9 TC 0 Z9 0 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD JUN PY 2014 VL 123 IS 6 BP 425 EP 427 DI 10.1177/0003489414526846 PG 3 WC Otorhinolaryngology SC Otorhinolaryngology GA AJ8RH UT WOS:000337974100008 PM 24690989 ER PT J AU Naka, A Wolf, A Renner, B Mueller, CA AF Naka, Asami Wolf, Axel Renner, Bertold Mueller, Christian A. TI A Novel Device for the Clinical Assessment of Intranasal Trigeminal Sensitivity SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE carbon dioxide; clinical; irritation; nasal; test; trigeminal ID ODOR IDENTIFICATION; OLFACTORY FUNCTION; NORMATIVE DATA; DISCRIMINATION AB Objective: Despite the significance of trigeminal pathology, practical clinical tests that accurately evaluate intranasal trigeminal function are scarce. The aim of the present study is to introduce a practical procedure for the assessment of intranasal trigeminal sensitivity. Methods: We developed a device to stimulate the nasal mucosa using carbon dioxide, which is self-administered intranasally by holding down a timed button until the required sensory response has been triggered. The trigeminal sensitivity is derived from the measured administration time in conjunction with the concentration of carbon dioxide administered. Sixty-three healthy participants were used to validate the device, after which the new device was compared with a standard lateralization task in an additional 16 participants. In 20 participants, the experiment was repeated to verify test-retest reliability. Results: Statistical analysis showed significant consistency in administration-duration in healthy individuals, including those in the test-retest group. Those participants with higher scores in the lateralization task were found to show higher intranasal sensitivity measured by the new device. Conclusion: Herein, we present the design and validation of a novel device for the practical assessment of intranasal trigeminal sensitivity. In this study, we demonstrate the efficacy and reliability of this device. C1 [Naka, Asami; Wolf, Axel; Mueller, Christian A.] Med Univ Vienna, Dept Otorhinolaryngol, A-1090 Vienna, Austria. [Renner, Bertold] Univ Erlangen Nurnberg, Dept Pharmacol, Erlangen, Germany. RP Mueller, CA (reprint author), Med Univ Vienna, Dept Otorhinolaryngol, Waehringer Guertel 18-20, A-1090 Vienna, Austria. EM christian.a.mueller@meduniwien.ac.at CR COMETTOMUNIZ JE, 1995, CHEM SENSES, V20, P191, DOI 10.1093/chemse/20.2.191 Eccles R, 1992, Rhinol Suppl, V14, P86 Frasnelli J, 2007, INT J PSYCHOPHYSIOL, V65, P177, DOI 10.1016/j.ijpsycho.2007.03.007 Hummel T, 2002, INT ARCH OCC ENV HEA, V75, P305, DOI 10.1007/s00420-002-0315-7 Hummel T, 2007, EUR ARCH OTO-RHINO-L, V264, P237, DOI 10.1007/s00405-006-0173-0 Hummel T., 1998, Rhinology (Utrecht), V36, P168 Hummel T, 2003, TOXICOL LETT, V140, P273, DOI 10.1016/S0378-4274(03)00078-X Hummel T, 1997, CHEM SENSES, V22, P39, DOI 10.1093/chemse/22.1.39 Hummel T, 2001, ANN OTO RHINOL LARYN, V110, P976 Hummel T, 2000, INT J PSYCHOPHYSIOL, V36, P147, DOI 10.1016/S0167-8760(99)00108-7 KOBAL G, 1989, EXPERIENTIA, V45, P130, DOI 10.1007/BF01954845 KOBAL G, 1985, PAIN, V22, P151, DOI 10.1016/0304-3959(85)90175-7 Kobal G., 1996, Rhinology (Utrecht), V34, P222 LEOPOLD DA, 1992, ANN OTO RHINOL LARYN, V101, P229 Renner B, 2007, J CLIN PHARMACOL, V47, P715, DOI 10.1177/0091270007299762 Shusterman DJ, 1997, AM J RHINOL, V11, P371, DOI 10.2500/105065897781286007 Silver WL, 2009, ANN NY ACAD SCI, V1170, P202, DOI 10.1111/j.1749-6632.2009.03894.x NR 17 TC 0 Z9 0 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD JUN PY 2014 VL 123 IS 6 BP 428 EP 433 DI 10.1177/0003489414527222 PG 6 WC Otorhinolaryngology SC Otorhinolaryngology GA AJ8RH UT WOS:000337974100009 PM 24690981 ER PT J AU Jesic, S Jotic, A Tomanovic, N Zivkovic, M Kolakovic, A Stankovic, A AF Jesic, Snezana Jotic, Ana Tomanovic, Nada Zivkovic, Maja Kolakovic, Ana Stankovic, Aleksandra TI Expression of Toll-Like Receptors 2, 4 and Nuclear Factor Kappa B in Mucosal Lesions of Human Otitis: Pattern and Relationship in a Clinical Immunohistochemical Study SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE toll-like receptors; nuclear factor kappa B; otitis; humans ID NONTYPABLE HAEMOPHILUS-INFLUENZAE; EPITHELIAL-CELLS; MEDIA; EAR; CHOLESTEATOMA; ACTIVATION; INNATE; TOLL-LIKE-RECEPTOR-4; RESPONSES; EFFUSION AB Objectives: The objectives were to detect and compare the expression of toll-like receptors (TLRs) 2, 4 and nuclear factor kappa B in mucosal lesions of chronic otitis. Methods: Fifty-five tissue samples obtained from children and adults operated on for otitis were investigated by semiquantitative immunohistochemical methods using polyclonal antibodies for TLR 2, 4 and NFkB. Kruskal-Wallis, Mann-Whitney, and Kendall's tau rank correlation tests were used. Results: Stronger expression of TLR2, 4 was found in inflamed mucosa than in the control for children and adults (TLR2: H = 23.86, P < .001; TLR4: H = 22.80, P < .001) (TLR2: H = 17.53, P < .001; TLR4: H = 11.99, P < .001); in cholesteatoma perimatrix compared to tubotympanic lesions in children (TLR2: H = 11.06, P = .004; TLR4: H = 10.61, P = .005) and adults (TLR2: H = 10.73, P =.013; TLR4: H = 9.65, P = .021). No differences were found in NFkB expression (H = 0.042, P = .99). Significant correlations were found for all pairs of molecules in cholesteatoma and tubotympanic mucosa of adults (TLR2, 4: P = .002, P < .001; TLR2-NfkB: P = .032, P = .021; TLR4-NFkB: P =.035, P = .0013), only TLR4-NFkB in tubotympanic otitis of children (P = .026). Conclusions: Toll-like receptors 2, 4 and NFkB mediate inflammation in cholesteatoma and mucosal lesions of tubotympanic otitis in children and adults. Significant correlations between all pairs of molecules in all samples were detected in adults, but only TLR4-NFkB in children. C1 [Jesic, Snezana; Jotic, Ana] Univ Belgrade, Sch Med, Clin Otorhinolaryngol & Maxillofacial Surg, Clin Ctr Serbia, Belgrade 11000, Serbia. [Tomanovic, Nada] Univ Belgrade, Sch Med, Inst Pathol, Belgrade 11000, Serbia. [Zivkovic, Maja; Kolakovic, Ana; Stankovic, Aleksandra] Univ Belgrade, Lab Radiobiol & Mol Genet, Vinca Inst Nucl Sci, Belgrade 11000, Serbia. RP Jesic, S (reprint author), Univ Belgrade, Sch Med, Clin Otorhinolaryngol & Maxillofacial Surg, Clin Ctr Serbia, Pasterova 2, Belgrade 11000, Serbia. EM xeniam@sezampro.rs FU Ministry of Education, Science and Technological Development of the Republic of Serbia [OI175085] FX The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: The study is supported by the Ministry of Education, Science and Technological Development of the Republic of Serbia, research project OI175085. CR Doyle SL, 2006, BIOCHEM PHARMACOL, V72, P1102, DOI 10.1016/j.bcp.2006.07.010 Drexler SK, 2010, INT J BIOCHEM CELL B, V42, P506, DOI 10.1016/j.biocel.2009.10.009 Fan J, 2003, J CLIN INVEST, V112, P1234, DOI 10.1172/JCI200318696 Granath A, 2011, J INFECTION, V63, P174, DOI 10.1016/j.jinf.2011.06.006 Hamajima Y, 2010, CELL PROLIFERAT, V43, P457, DOI 10.1111/j.1365-2184.2010.00695.x Han FC, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0043010 Hirai H, 2013, INT J PEDIATR OTORHI, V77, P674, DOI 10.1016/j.ijporl.2013.01.010 Hirano T, 2007, FEMS IMMUNOL MED MIC, V49, P75, DOI 10.1111/j.1574-695X.2006.00186.x Komori M, 2011, PEDIATR RES, V69, P101, DOI 10.1203/PDR.0b013e3182055237 Lawrence T, 2007, INT J EXP PATHOL, V88, P85, DOI 10.1111/j.1365-2613.2006.00507.x Lee SY, 2011, CLIN EXP OTORHINOLAR, V4, P163, DOI 10.3342/ceo.2011.4.4.163 Leichtle A, 2011, CURR ALLERGY ASTHM R, V11, P78, DOI 10.1007/s11882-010-0158-3 Lowrence TC, 2009, OLD SPRING HARB PERS, V1 Moon SK, 2007, INFECT IMMUN, V75, P3361, DOI 10.1128/IAI.01886-06 Moon SK, 2008, FASEB J, V22 Okazaki T, 2003, BIOCHEM BIOPH RES CO, V300, P807, DOI 10.1016/S0006-291X(02)02932-7 O'Neill LAJ, 2006, CURR OPIN IMMUNOL, V18, P3, DOI 10.1016/j.coi.2005.11.012 Ovesen T, 2003, ACTA OTO-LARYNGOL, V123, P306, DOI 10.1080/00016480310001169 Parker LC, 2007, CLIN EXP IMMUNOL, V147, P199 Remer KA, 2006, J IMMUNOL METHODS, V313, P1, DOI 10.1016/j.jim.2005.07.026 Shin IH, 2009, CLIN EXP OTORHINOLAR, V2, P131, DOI 10.3342/ceo.2009.2.3.131 Shuto T, 2001, P NATL ACAD SCI USA, V98, P8774, DOI 10.1073/pnas.151236098 Si Yu, 2012, Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi, V47, P388 Szczepanski M, 2006, EUR ARCH OTO-RHINO-L, V263, P603, DOI 10.1007/s00405-006-0030-1 Trune DR, 2009, BRAIN RES, V1277, P90, DOI 10.1016/j.brainres.2009.02.047 NR 25 TC 0 Z9 0 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD JUN PY 2014 VL 123 IS 6 BP 434 EP 441 DI 10.1177/0003489414527229 PG 8 WC Otorhinolaryngology SC Otorhinolaryngology GA AJ8RH UT WOS:000337974100010 PM 24690988 ER PT J AU Sulica, L AF Sulica, Lucian TI Hoarseness Misattributed to Reflux: Sources and Patterns of Error SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE dysphonia; hoarseness; laryngopharyngeal reflux; paresis; stroboscopy; sulcus ID GASTROESOPHAGEAL-REFLUX AB Objective: This study aimed to identify voice disorders commonly misidentified as reflux and sources of such misattribution. Study Design: Retrospective chart review. Methods: Twenty-six patients carrying a diagnosis of reflux alone presenting for second-opinion evaluation were identified from among 381 new patients presenting with a chief complaint of hoarseness over an 8-month period. Patients specifically referred for further workup were excluded. Results: Average duration of reflux treatment was 10.6 +/- 9.0 weeks. In no case was reflux alone the cause of hoarseness. Eleven (42%) had phonotraumatic lesions, 9 (34%) had neurologic disorders, 5 (19%) had age-related changes, and 1 (4%) was infectious. Twenty-two (85%) abnormalities were diagnosed by dynamic laryngeal examination with improved optics, including stroboscopy. Only 4 (15%) represented disorders routinely diagnosed with flexible fiberoptic laryngoscopy. Conclusion: Hoarse patients with no apparent cause for dysphonia other than reflux after flexible laryngoscopy, or who fail to improve with appropriate treatment, may benefit from further laryngeal investigation rather than continued empiric treatment or further reflux evaluation. C1 Weill Cornell Med Coll, Dept Otolaryngol Head & Neck Surg, New York, NY 10021 USA. RP Sulica, L (reprint author), Weill Cornell Med Coll, Dept Otolaryngol Head & Neck Surg, 1305 York Ave,5th Floor, New York, NY 10021 USA. EM lus2005@med.cornell.edu CR CHERRY J, 1968, LARYNGOSCOPE, V78, P1937, DOI 10.1288/00005537-196811000-00007 Hopkins C, 2006, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD005054.pub2 KOUFMAN JA, 1991, LARYNGOSCOPE, V101, P1 MCNALLY PR, 1989, DIGEST DIS SCI, V34, P1900 Ozturk O, 2006, EUR ARCH OTO-RHINO-L, V263, P935, DOI 10.1007/s00405-006-0097-8 Smit CF, 2000, ARCH OTOLARYNGOL, V126, P827 NR 6 TC 0 Z9 0 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD JUN PY 2014 VL 123 IS 6 BP 442 EP 445 DI 10.1177/0003489414527225 PG 4 WC Otorhinolaryngology SC Otorhinolaryngology GA AJ8RH UT WOS:000337974100011 PM 24690986 ER PT J AU Schleiffarth, JR Bayon, R Chang, KE Van Daele, DJ Pagedar, NA AF Schleiffarth, J. Robert Bayon, Rodrigo Chang, Kristi E. Van Daele, Douglas J. Pagedar, Nitin A. TI Ketorolac After Free Tissue Transfer: A Comparative Effectiveness Study SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE aspirin; free tissue transfer flaps; ketorolac ID POSTOPERATIVE PAIN AB Objective: We sought to compare postoperative pain and complications in patients undergoing free tissue transfer for reconstruction of head and neck defects with and without ketorolac. Methods: In this retrospective cohort study, we identified patients who underwent head and neck free tissue transfer procedures at the University of Iowa between July 2010 and December 2012. A subset of patients received ketorolac as an anti-platelet agent. Main outcome measures include postoperative analgesic use, pain scores, and bleeding complications. Results: We identified 138 free tissue transfers, with 42 procedures in the ketorolac cohort. In the first 7 postoperative days, patients in the ketorolac and non-ketorolac cohorts received equivalent narcotic doses (morphine equivalents, 48.9 mg/day vs 46.6 mg/day, P =.72). The ketorolac group reported higher mean pain scores (3.1 vs 2.4, P = .004). Ketorolac use was not associated with need for transfusion (P = .86) or number of days with neck drains (P = .79). Conclusion: Ketorolac did not demonstrate a significant analgesic effect in this group of patients in terms of pain scores and opioid requirements. However, there also was no evidence to suggest a higher likelihood of bleeding complications. Ketorolac may be safely used as an anti-platelet agent, with narcotic requirements unchanged. C1 [Schleiffarth, J. Robert; Bayon, Rodrigo; Chang, Kristi E.; Van Daele, Douglas J.; Pagedar, Nitin A.] Univ Iowa, Dept Otolaryngol Head & Neck Surg, Iowa City, IA 52242 USA. RP Pagedar, NA (reprint author), Univ Iowa, Dept Otolaryngol Head & Neck Surg, 200 Hawkins Dr, Iowa City, IA 52242 USA. EM nitin-pagedar@uiowa.edu CR DEANDRADE JR, 1994, ORTHOPEDICS, V17, P157 Kehlet H, 2001, BRIT J ANAESTH, V87, P62, DOI 10.1093/bja/87.1.62 Lee KT, 2012, PLAST RECONSTR SURG, V129, P1322, DOI 10.1097/PRS.0b013e31824ec33f LITVAK KM, 1990, CLIN PHARMACY, V9, P921 MACDONALD DJF, 1985, BRIT J ANAESTH, V57, P904, DOI 10.1093/bja/57.9.904 MCQUAY HJ, 1986, CLIN PHARMACOL THER, V39, P89 Morrison RS, 2003, PAIN, V103, P303, DOI 10.1016/S0304-3959(02)00458-X Sommer M, 2008, EUR J ANAESTH, V25, P267, DOI 10.1017/S05021507003031 Strom BL, 1996, JAMA-J AM MED ASSOC, V275, P376, DOI 10.1001/jama.275.5.376 VARRASSI G, 1994, ANESTH ANALG, V78, P514 NR 10 TC 0 Z9 0 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD JUN PY 2014 VL 123 IS 6 BP 446 EP 449 DI 10.1177/0003489414526849 PG 4 WC Otorhinolaryngology SC Otorhinolaryngology GA AJ8RH UT WOS:000337974100012 PM 24690984 ER PT J AU Miller, CK Kelchner, LN de Alarcon, A Willging, JP AF Miller, Claire Kane Kelchner, Lisa N. de Alarcon, Alessandro Willging, J. Paul TI Compensatory Laryngeal Function and Airway Protection in Children Following Airway Reconstruction SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE airway protection; aspiration; dysphagia; laryngotracheal reconstruction ID PEDIATRIC LARYNGOTRACHEAL RECONSTRUCTION; OUTCOMES; PHONATION; HISTORY; VOICE AB Objectives: Laryngotracheal reconstruction (LTR) procedures for repair of complex congenital or acquired airway stenosis of the larynx and/or trachea in pediatric patients have advanced over recent decades. The aim of the present project was to investigate the relationships among diagnoses, type of surgical intervention, and laryngeal findings in a post-LTR patient cohort to identify factors associated with adequate airway protection and swallowing outcomes. Methods: A retrospective review of 30 airway patients undergoing simultaneous or close interval functional laryngeal and swallowing examinations was completed. Analyses of the data were performed to examine factors associated with postoperative airway protection and swallowing function. The patient cohort was separated into 2 groups according to the adequacy of their airway protection (aspiration and no aspiration) as judged by clinicians via instrumental examination. Results: Data analyses revealed statistically significant differences between the 2 groups for 3 key parameters: laryngeal closure, laryngeal closure timeliness (relative to bolus flow), and overall swallowing coordination. Conclusions: These findings contribute to the knowledge of laryngeal closure patterns present in patients undergoing airway reconstruction and the effect on the essential laryngeal function of airway protection during swallowing. Implications of the data for swallowing function in this population are discussed. C1 [Miller, Claire Kane] Cincinnati Childrens Hosp Med Ctr, Div Speech Language Pathol, Aerodigest & Esophageal Ctr, Cincinnati, OH 45229 USA. [Miller, Claire Kane; Kelchner, Lisa N.] Univ Cincinnati, Div Commun Sci & Disorders, Cincinnati, OH USA. [Kelchner, Lisa N.] Cincinnati Childrens Hosp Med Ctr, Div Speech Language Pathol, Cincinnati, OH 45229 USA. [de Alarcon, Alessandro; Willging, J. Paul] Cincinnati Childrens Hosp Med Ctr, Div Pediat Otolaryngol Head & Neck Surg, Cincinnati, OH 45229 USA. [de Alarcon, Alessandro; Willging, J. Paul] Univ Cincinnati, Coll Med, Dept Otolaryngol Head & Neck Surg, Cincinnati, OH USA. RP Miller, CK (reprint author), Cincinnati Childrens Hosp Med Ctr, Div Speech Language Pathol, Aerodigest & Esophageal Ctr, ML 11002,3333 Burnet Ave, Cincinnati, OH 45229 USA. EM Claire.Miller@cchmc.org CR Ardran A, 1952, BRIT J RADIOL, V25, P406 Baker S, 2006, J VOICE, V20, P631, DOI 10.1016/j.jvoice.2005.08.012 Cotton R. T., 1995, Acta Oto-Rhino-Laryngologica Belgica, V49, P367 de Alarcon A, 2008, OTOLARYNG CLIN N AM, V41, P959, DOI 10.1016/j.otc.2008.04.004 Gustafson LM, 2000, OTOLARYNG HEAD NECK, V123, P430, DOI 10.1067/mhn.2000.109007 Halstead LA, 1999, OTOLARYNG HEAD NECK, V120, P208, DOI 10.1016/S0194-5998(99)70408-0 Kelchner LN, 2008, CURR OPIN OTOLARYNGO, V16, P221, DOI 10.1097/MOO.0b013e3282febd24 Kelchner LN, 2010, ANN OTO RHINOL LARYN, V119, P383 Koempel JA, 2008, OTOLARYNG CLIN N AM, V41, P825, DOI 10.1016/j.otc.2008.04.014 Martin-Harris B, 2007, J SPEECH LANG HEAR R, V50, P585, DOI 10.1044/1092-4388(2007/041) Miller AJ, 1986, DYSPHAGIA, V1, P91, DOI 10.1007/BF02407121 Miller CK, 2009, INT J PEDIATR OTORHI, V73, P573, DOI 10.1016/j.ijporl.2008.12.024 Rizzi MD, 2009, OTOLARYNG HEAD NECK, V140, P348, DOI 10.1016/j.otohns.2008.11.035 Rosenbek JC, 1996, DYSPHAGIA, V11, P93, DOI 10.1007/BF00417897 Rutter MJ, 2002, PEDIAT OTOLARYNGOLOG, P1519 Santos D, 2010, LARYNGOSCOPE, V120, P815, DOI 10.1002/lary.20823 Smith M, 2010, ARCH OTOLARYNG HEAD, V136, P60 SMITH ME, 1992, ANN OTO RHINOL LARYN, V101, P731 Willging JP., 2002, LARYNGOSCOPE, V110, P825 NR 19 TC 0 Z9 0 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD MAY PY 2014 VL 123 IS 5 BP 305 EP 313 DI 10.1177/0003489414525920 PG 9 WC Otorhinolaryngology SC Otorhinolaryngology GA AG5YF UT WOS:000335494400001 PM 24642589 ER PT J AU Singh, NP Walker, RJE Cowan, F Davidson, AC Roberts, DN AF Singh, Narinder Pal Walker, Robbie James Eades Cowan, Fiona Davidson, Arthur Craig Roberts, David Newton TI Retrograde Air Escape via the Nasolacrimal System: A Previously Unrecognized Complication of Continuous Positive Airway Pressure in the Management of Obstructive Sleep Apnea SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE continuous positive airway pressure; nasolacrimal duct; eye; obstructive sleep apnea AB Background: Continuous positive airway pressure (CPAP) is the gold standard treatment for moderate to severe obstructive sleep apnoea (OSA). Eye-related side effects of CPAP are commonly attributed to a poorly sealed mask, allowing leaked air to blow over the eye. Cases: We present 3 cases where attended polysomnography (A-PSG) demonstrated CPAP-associated retrograde air escape via the nasolacrimal system (CRANS) in the absence of any mask leaks. Symptoms included dry eye, epiphora, air escape from the medial canthus, and eyelid flutter. Symptoms were controlled with a variety of surgical and nonsurgical techniques. Conclusions: CRANS represents a previously undescribed clinical entity. CRANS may be responsible for some CPAP-related eye side effects and possibly for rarer secondary eye complications, including conjunctivitis and corneal ulceration. CRANS should be suspected in any patient on CPAP complaining of eye symptoms. CRANS may be diagnosed through careful observation during A-PSG and confirmed by performing a "saline bubble test." Management options include nonsurgical (mask alternatives, humidification, nasopharyngeal airway) and surgical techniques (nasal airway surgery, inferior turbinate out-fracture and adhesion, injection of bulking agent around Hasner's valve). C1 [Singh, Narinder Pal] Univ Sydney, Westmead Hosp, Dept Otolaryngol Head & Neck Surg, Sydney, NSW 2006, Australia. [Walker, Robbie James Eades; Cowan, Fiona; Roberts, David Newton] Guys & St Thomas NHS Fdn Trust, Dept Otolaryngol Head & Neck Surg, London, England. [Davidson, Arthur Craig] Guys & St Thomas NHS Fdn Trust, Lane Fox Sleep Disorders Unit, London, England. RP Singh, NP (reprint author), Westmead Hosp, Dept Otolaryngol Head & Neck Surg, Hawkesbury Rd, Westmead, NSW 2154, Australia. EM narinder@ents.com.au CR Echternach M, 2008, LARYNGOSCOPE, V118, P375, DOI 10.1097/MLG.0b013e31815a9eea Giles TL, 2006, COCHRANE DB SYST REV, DOI [10.1002/14651858.CD001106.pub3, 10.1002/14651858.CD001106.pub2] Gordon P, 2005, THORAX, V60, P68, DOI 10.1136/thx.2003.007195 Harrison Wendy, 2007, Optometry, V78, P352, DOI 10.1016/j.optm.2006.12.015 Kakkar RK, 2007, CHEST, V132, P1057, DOI 10.1378/chest.06-2432 Massie CA, 2003, CHEST, V123, P1112, DOI 10.1378/chest.123.4.1112 Mirante J., 2006, LACRIMAL SYST, P25, DOI 10.1007/978-0-387-35267-1_3 Pepin JL, 1999, AM J RESP CRIT CARE, V160, P1124 Pirsig W, 2000, EUR ARCH OTO-RHINO-L, V257, P570, DOI 10.1007/s004050000278 STAUFFER JL, 1984, CHEST, V86, P802 Tucker NA, 1996, ARCH OPHTHALMOL-CHIC, V114, P1231 NR 11 TC 0 Z9 0 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD MAY PY 2014 VL 123 IS 5 BP 321 EP 324 DI 10.1177/0003489414525924 PG 4 WC Otorhinolaryngology SC Otorhinolaryngology GA AG5YF UT WOS:000335494400003 PM 24642587 ER PT J AU Birdane, L Muluk, NB Cingi, C Burukoglu, D Fidan, V Incesulu, A AF Birdane, Leman Muluk, Nuray Bayar Cingi, Cemal Burukoglu, Dilek Fidan, Vural Incesulu, Armagan TI Evaluation of the Efficacy of Curcumin in Experimentally Induced Acute Otitis Media in Rats SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE curcumin; antibiotic; experimentally induced acute otitis media; rats; histological examination. ID NF-KAPPA-B; ACTIVATION; LONGA; MODEL AB Objectives: We investigated the effect of curcumin (CMN) in the treatment of experimentally induced acute otitis media (AOM) in rats. Method: Thirty-two Sprague-Dawley female rats were used, yielding 64 temporal bones. Group 1 was the control group. For groups 2 to 4, AOM was induced experimentally, and saline, antibiotics (sulbactam-ampicillin), or CMN were administered for 14 days to groups 2, 3, and 4, respectively. During the histological examination, thickening of the tympanic membrane, damage to the epithelium, inflammation, and sclerosis were evaluated. Results: The AOM+antibiotic and AOM+CMN groups exhibited reduced histological damage compared with the AOM+saline group. No significant differences in thickening of the tympanic membrane or damage to the epithelium or inflammation were observed between the AOM+antibiotic and the AOM+CMN groups. However, the sclerosis values of the AOM+CMN group were significantly lower than those of the AOM+antibiotic group. Conclusion: CMN treatment resulted in similar effects on the experimentally induced AOM model as did the antibiotic treatment. The efficacy of this treatment may be related to its effects on the production of various inflammatory cytokines. In light of the worldwide increase in antibiotic resistance and the mild side effects of CMN, we suggest that CMN therapy may be a promising option in AOM treatment. C1 [Birdane, Leman; Fidan, Vural] Yunus Emre State Hosp, Dept Otorhinolaryngol, Eskisehir, Turkey. [Muluk, Nuray Bayar] Kirikkale Univ, Fac Med, Dept Otorhinolaryngol, Kirikkale, Turkey. [Cingi, Cemal; Incesulu, Armagan] Eskisehir Osmangazi Univ, Fac Med, Dept Otorhinolaryngol, TR-26020 Eskisehir, Turkey. [Burukoglu, Dilek] Eskisehir Osmangazi Univ, Fac Med, Dept Histol, TR-26020 Eskisehir, Turkey. RP Cingi, C (reprint author), Eskisehir Osmangazi Univ, Fac Med, ENT Dept, TR-26020 Eskisehir, Turkey. EM ccingi@gmail.com CR 52nd WMA. General Assembly, 2000, JAMA, V284, P3043 Abera Bayehe, 2009, Ethiop Med J, V47, P271 BAEUERLE PA, 1994, ANNU REV IMMUNOL, V12, P141, DOI 10.1146/annurev.immunol.12.1.141 Bauchner H, 2006, PEDIATRICS, V117, P1009, DOI 10.1542/peds.2005-2172 CHAN KH, 1994, LARYNGOSCOPE, V104, P970 Chen D, 2008, PHARMACOLOGY, V82, P264, DOI 10.1159/000161127 CHOLE RA, 1978, J NUTR, V108, P1008 Corbeel L, 2007, EUR J PEDIATR, V166, P511, DOI 10.1007/s00431-007-0461-8 Eybl V, 2004, TOXICOL LETT, V151, P79, DOI 10.1016/j.toxlet.2004.02.019 GASPARINI G, 1995, BREAST CANCER RES TR, V36, P103, DOI 10.1007/BF00666032 Hultcrantz M, 2000, AM J OTOL, V21, P36, DOI 10.1016/S0196-0709(00)80110-6 Lao Christopher D, 2006, BMC Complement Altern Med, V6, P10, DOI 10.1186/1472-6882-6-10 Lee CW, 2006, J CELL PHYSIOL, V207, P174, DOI 10.1002/jcp.20549 Liu K, 2013, INT IMMUNOL McCracken GH, 2002, ANN EMERG MED, V39, P413, DOI 10.1067/mem.2002.122772 McLinn S., 1978, CURRENT CHEMOTHERAPY, V1, P123 Milobedzka J, 1910, BER DTSCH CHEM GES, V43, P2163, DOI 10.1002/cber.191004302168 Packiavathy IA, APPL MICROBIOL BIOTE PARADISE JL, 1980, PEDIATRICS, V65, P917 Rovers MM, 2004, LANCET, V363, P465, DOI 10.1016/S0140-6736(04)15495-0 Rudrappa T, 2008, J AGR FOOD CHEM, V56, P1955, DOI [10.1021/jf072591j, 10.1021/jf07259lj] BHAVANISHANKAR TN, 1980, INDIAN J EXP BIOL, V18, P73 Strimpakos AS, 2008, ANTIOXID REDOX SIGN, V10, P511, DOI 10.1089/ars.2007.1769 Sugita R., J INFECT CHEMOTHER Surh YJ, 2001, MUTAT RES-FUND MOL M, V480, P243, DOI 10.1016/S0027-5107(01)00183-X Syrjanen RK, 2005, PEDIATR INFECT DIS J, V24, P801, DOI 10.1007/01.inf.0000178072.83531.4f Tirkey Naveen, 2005, BMC Pharmacology, V5, P15, DOI 10.1186/1471-2210-5-15 Zhou HY, 2011, CURR DRUG TARGETS, V12, P332 NR 28 TC 0 Z9 0 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD MAY PY 2014 VL 123 IS 5 BP 325 EP 332 DI 10.1177/0003489414525925 PG 8 WC Otorhinolaryngology SC Otorhinolaryngology GA AG5YF UT WOS:000335494400004 PM 24642584 ER PT J AU Hidaka, H Ishida, E Suzuki, T Matsutani, S Kobayashi, T Takahashi, S AF Hidaka, Hiroshi Ishida, Eiichi Suzuki, Takahiro Matsutani, Sachiko Kobayashi, Toshimitsu Takahashi, Shoki TI Unusual Parapharyngeal Extension of Peritonsillar Abscess to the Masticator Space: Successfully Drained by Extraoral and Intraoral Endoscopic Approaches SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE peritonsillar abscess; masticator space; deep neck infection; drainage; endoscopy ID INFRATEMPORAL FOSSA; INFECTION; CT; PATHWAYS AB Objective: The object was to describe 2 novel cases of peritonsillar abscess showing peculiar extension to the masticator space. Methods: The methods included clinical case records, including computed tomography and surgical approaches. Results: Both patients we encountered were suffering from systematic diseases, with case 1 involving a 75-year-old man with diabetes mellitus and case 2 involving a 90-year-old woman taking immunosuppressive medications. The abscesses were peritonsillar in origin, extending primarily to the parapharyngeal space, with unusual secondary extension to the masticator space. Extraoral drainage conducted in case 1 was useful for assessing the masticator space and surrounding spaces, but endoscopy-assisted intraoral drainage in case 2 was less invasive, obviating the need for identifying the facial nerve. Conclusions: It is important to bear in mind that patients suffering from systemic diseases may display unusual extension of deep head and neck infections, and enhanced computed tomography is a useful modality for evaluating such extensions. C1 [Hidaka, Hiroshi; Ishida, Eiichi; Suzuki, Takahiro; Kobayashi, Toshimitsu] Tohoku Univ, Grad Sch Med, Dept Otolaryngol Head & Neck Surg, Sendai, Miyagi 9808575, Japan. [Matsutani, Sachiko] Sendai Red Cross Hosp, Dept Otolaryngol, Sendai, Miyagi, Japan. [Takahashi, Shoki] Tohoku Univ, Grad Sch Med, Dept Diagnost Radiol, Sendai, Miyagi 9808575, Japan. RP Hidaka, H (reprint author), Tohoku Univ, Grad Sch Med, Dept Otolaryngol HNS, Aoba Ku, 1-1 Seiryomachi, Sendai, Miyagi 9808575, Japan. EM ZAY00015@nifty.com CR Akst LM, 2005, AM J OTOLARYNG, V26, P35, DOI 10.1016/j.amjoto.2004.06.015 Al-Belasy, 2005, J ORAL MAXILLOFAC SU, V63, P36 Barnsby-Zachary GM, 1948, BR DENT J, V84, P10 DOXEY GP, 1985, LARYNGOSCOPE, V95, P1444 Hasegawa J, 2011, AURIS NASUS LARYNX, V38, P101, DOI 10.1016/j.anl.2010.06.001 Huang TT, 2004, HEAD NECK-J SCI SPEC, V21, P169 Maroldi R, 2012, SEMIN ULTRASOUND CT, V33, P432, DOI 10.1053/j.sult.2012.06.008 NEWMAN MH, 1974, ARCH OTOLARYNGOL, V99, P128 Prosser JD, 2011, LARYNGOSCOPE, V121, P1601, DOI 10.1002/lary.21863 Schuknecht B, 2008, EUR RADIOL, V18, P1972, DOI 10.1007/s00330-008-0946-5 Yonetsu K, 1998, AM J NEURORADIOL, V19, P123 NR 11 TC 0 Z9 0 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD MAY PY 2014 VL 123 IS 5 BP 333 EP 337 DI 10.1177/0003489414526360 PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA AG5YF UT WOS:000335494400005 PM 24682731 ER PT J AU Hettige, R Pankhania, M Demetriou, V Draper, M AF Hettige, Roland Pankhania, Miran Demetriou, Vias Draper, Mark TI Laryngeal Mask Airways and Use of a Boyle-Davis Gag in ENT Surgery: Is There a Learning Curve? A Prospective Analysis SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE laryngeal mask airway; Boyle-Davis gag; airway; intervention; experience ID ADENOTONSILLECTOMIES AB Objectives: The objective was to identify whether the experience of the operating surgeon was relevant to the frequency of the laryngeal mask airway (LMA) airway obstruction or change to an endotracheal tube during ear, nose, and throat surgery. Methods: Data were prospectively collected for 186 patients undergoing a procedure with the use of a Boyle-Davis gag and LMA over 12 months in a district-general hospital in the United Kingdom. patient demographics (age, mallampati grade), grade of surgeon, grade of anesthetist, LMA size inserted, and any intraoperative adjustments needed were recorded. Results: There was an overall intraoperative airway intervention rate of 21%. The experience of the surgeon affected the rate of intraoperative airway interventions encountered, reflected by the significantly lower rate of airway complications (ie, 10%) seen when associate specialists perform these types of procedures compared to other grades of surgeon (Fisher's exact test 2-tailed P value = .04). A significant complication rate of 50% was seen with core surgical trainees compared to other grades of surgeon (Fisher's exact test 2-tailed P value = .002). Conclusions: The results of this study suggest there may be a learning curve for otolaryngology trainees when using a LMA. However, larger studies and further subanalyses are essential before further conclusions can be made. C1 [Hettige, Roland] Royal Berkshire Hosp, Dept Otolaryngol, Oxford OX3 7ST, England. [Pankhania, Miran; Demetriou, Vias; Draper, Mark] Milton Keynes Dist Gen Hosp, Dept Otolaryngol, Oxford Deanery, England. RP Hettige, R (reprint author), Royal Berkshire Hosp, Dept Otolaryngol, 187 Headley Way, Oxford OX3 7ST, England. EM roland.hettige@gmail.com CR Aziz Leena, 2006, J Coll Physicians Surg Pak, V16, P685 Brimacombe J, 2000, BRIT J ANAESTH, V84, P290 DAUM REO, 1992, J LARYNGOL OTOL, V106, P28, DOI 10.1017/S0022215100118511 Doksrod S, 2010, EUR J ANAESTH, V27, P941, DOI 10.1097/EJA.0b013e32833d69c6 Gupta S, 1999, ACTA ANAESTH SCAND, V43, P789 Hern JD, 1999, CLIN OTOLARYNGOL, V24, P122 Lim N. L. S. H., 2000, Annals Academy of Medicine Singapore, V29, P764 Mandel Jeff E, 2010, Anesthesiol Clin, V28, P469, DOI 10.1016/j.anclin.2010.07.005 Peng A, 2011, ARCH OTOLARYNGOL, V137, P42, DOI 10.1001/archoto.2010.230 WEBSTER AC, 1993, CAN J ANAESTH, V40, P1171 NR 10 TC 0 Z9 0 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD MAY PY 2014 VL 123 IS 5 BP 338 EP 342 DI 10.1177/0003489414526365 PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA AG5YF UT WOS:000335494400006 PM 24668055 ER PT J AU Chen, ZN Sun, XQ Zhou, HQ Shi, HB Wu, YQ Yin, SK AF Chen, Zhengnong Sun, Xiaoqiang Zhou, Huiqun Shi, Haibo Wu, Yaqin Yin, Shankai TI Comparison of Hearing Results of Malleovestibulopexy and Total Ossicular Replacement Prosthesis for Chronic Otitis Media Patients With a Mobile Stapes Footplate SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE chronic otitis media; functional hearing result; malleostapedotomy; total ossicular replacement prosthesis ID MALLEUS GRIP PROSTHESIS; MALLEOSTAPEDOTOMY; RECONSTRUCTION; OSSICULOPLASTY; STAPEDECTOMY; EXPERIENCE; IMPLANTS AB Objective: This study aimed to assess differences in hearing outcomes using the malleostapedotomy or malleovestibulopexy (MVP) and total ossicular replacement prosthesis (TORP) techniques in chronic otitis media patients with a mobile stapes footplate. Study Design: Case series with planned data collection. Setting: A university medical center. Subjects and Methods: In total, 27 patients with chronic otitis media at the Sixth Hospital affiliated with Shanghai Jiao Tong University, between January and October 2010, were included. All patients had destruction of incus and stapes superstructures and a mobile stapes footplate. In all patients, surgery was performed under general anesthesia by a retroauricular approach. After the lesions were removed completely, ossicular reconstruction was performed using 1 of the techniques. In all patients, pure-tone audiograms were assessed before and 12 months after surgery. Results: Thirteen patients underwent MVP surgery, whereas the other 14 cases received traditional TORP surgery. All patients showed improvements in functional hearing after surgery. Although the numbers of ears that had closure of the air-bone gap within 20 dB in the MVP group were not statistically significantly higher than those in the TORP group (Fisher's exact test, P > .05), the average postoperative gain of the MVP group was significantly higher than that of the TORP group (t test, P < .05). Conclusion: Functional hearing in chronic otitis media patients with a mobile stapes footplate was better in those who underwent MVP surgery than in those who underwent TORP surgery. C1 [Chen, Zhengnong; Zhou, Huiqun; Shi, Haibo; Wu, Yaqin; Yin, Shankai] Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 6, Otolaryngol Inst, Dept Otolaryngol, Shanghai 200233, Peoples R China. [Sun, Xiaoqiang] Luzhou Med Coll, Affiliated Hosp, Dept Otolaryngol, Luzhou, Sichuan, Peoples R China. RP Yin, SK (reprint author), Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 6, Otolaryngol Inst, 600 Yishan Rd, Shanghai 200233, Peoples R China. EM yinshankai@china.com FU Shanghai municipal hospitals [SHDC12010119] FX The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This study was supported by the joint research projects of Shanghai municipal hospitals (SHDC12010119). CR Dalchow CV, 2007, ADV OTO-RHINO-LARYNG, V65, P215, DOI 10.1159/000098825 Dalchow CV, 2001, OTOLARYNG HEAD NECK, V125, P628, DOI 10.1067/mhn.2001.120397 Fisch U, 2001, OTOL NEUROTOL, V22, P776, DOI 10.1097/00129492-200111000-00011 Gluth MB, 2011, OTOL NEUROTOL, V32, P242, DOI 10.1097/MAO.0b013e3182015f44 Hales NW, 2007, AM J OTOLARYNG, V28, P164, DOI 10.1016/j.amjoto.2006.08.005 Iniguez-Cuadra R, 2010, OTOL NEUROTOL, V31, P409, DOI 10.1097/MAO.0b013e3181cc04b5 Kisilevsky V, 2009, J OTOLARYNGOL-HEAD N, V38, P595, DOI 10.2310/7070.2009.080202 Magliulo G, 2007, J LARYNGOL OTOL, V121, P1148, DOI 10.1017/S0022215107008766 Martin AD, 2004, LARYNGOSCOPE, V114, P61, DOI 10.1097/00005537-200401000-00010 Neff BA, 2003, LARYNGOSCOPE, V113, P1525, DOI 10.1097/00005537-200309000-00021 Nguyen D-Q, 2005, Ann Otolaryngol Chir Cervicofac, V122, P187, DOI 10.1016/S0003-438X(05)82347-3 Sarac S, 2006, ANN OTO RHINOL LARYN, V115, P317 SCHUKNECHT HF, 1986, ANN OTO RHINOL LARYN, V95, P531 SHEEHY JL, 1982, LARYNGOSCOPE, V92, P258 Tange R. A., 1996, ORL (Basel), V58, P143 Vassbotn FS, 2007, EUR ARCH OTO-RHINO-L, V264, P21, DOI 10.1007/s00405-006-0149-0 NR 16 TC 0 Z9 0 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD MAY PY 2014 VL 123 IS 5 BP 343 EP 346 DI 10.1177/0003489414526366 PG 4 WC Otorhinolaryngology SC Otorhinolaryngology GA AG5YF UT WOS:000335494400007 PM 24671548 ER PT J AU Romak, JJ Ekbom, DC Saleh, AM Orbelo, DM Maragos, NE AF Romak, Jonathan J. Ekbom, Dale C. Saleh, Amy M. Orbelo, Diana M. Maragos, Nicolas E. TI Superomedial Submucosal Partial Arytenoidectomy for Improved Posterior Glottic Closure: Surgical Technique and Case Presentation SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE dysphonia; endoscopic arytenoidectomy; glottic closure; prolapsed arytenoid; unilateral vocal fold paralysis; voice disorder ID VOCAL FOLD PARALYSIS; INJECTION LARYNGOPLASTY; MEDIAL ARYTENOIDECTOMY; CORD PARALYSIS; ADDUCTION; MEDIALIZATION; VALIDATION; QUALITY AB Objective: Endoscopic medial partial arytenoidectomy has been described previously for expansion of the posterior glottic airway in bilateral vocal fold paralysis. Superomedial submucosal partial arytenoidectomy (SSPA), a modification of this technique, can improve glottic closure in the setting of an obstructing anteromedially prolapsed arytenoid. We present our surgical technique and a case example. Methods and Results: A 45-year-old man presented with dysphonia attributable to unilateral true vocal fold paralysis. Laryngoscopy revealed right true vocal fold atrophy and an anteriorly prolapsed right arytenoid cartilage preventing posterior glottic closure during adduction. Right SSPA and ipsilateral vocal fold injection augmentation were performed without complication. One-month and 11-month postoperative evaluations showed marked improvement in voice, with complete glottic closure. Quality-of-life assessment and patient report showed a durable result at 50 months. Conclusion: SSPA may be a valuable technique in the management of breathy dysphonia associated with posterior glottic gap and other sequelae of the malpositioned arytenoid. C1 [Romak, Jonathan J.; Ekbom, Dale C.; Saleh, Amy M.; Orbelo, Diana M.; Maragos, Nicolas E.] Mayo Clin, Dept Otorhinolaryngol Head & Neck Surg, Rochester, MN 55905 USA. RP Ekbom, DC (reprint author), Mayo Clin, Dept Otorhinolaryngol Head & Neck Surg, 200 First St SW, Rochester, MN 55905 USA. EM ekbom.dale@mayo.edu CR Arviso LC, 2010, LARYNGOSCOPE, V120, P2237, DOI 10.1002/lary.21143 CRUMLEY RL, 1993, ANN OTO RHINOL LARYN, V102, P81 Danino J, 2000, J OTOLARYNGOL, V29, P13 Friedman AD, 2010, LARYNGOSCOPE, V120, P2042, DOI 10.1002/lary.21097 Hogikyan ND, 1999, J VOICE, V13, P557, DOI 10.1016/S0892-1997(99)80010-1 ISSHIKI N, 1978, ARCH OTOLARYNGOL, V104, P555 Kempster GB, 2009, AM J SPEECH-LANG PAT, V18, P124, DOI 10.1044/1058-0360(2008/08-0017) Kim HM, 2007, LARYNGOSCOPE, V117, P1611, DOI 10.1097/MLG.0b013e31806bf2e0 Mahieu H, 2001, 5TH ANNUAL LARYNGEAL Orbelo DM, 2008, PAPER PRESENTED AT C OSSOFF R H, 1983, Lasers in Surgery and Medicine, V2, P293, DOI 10.1002/lsm.1900020402 Prendes BL, 2012, LARYNGOSCOPE, V122, P2227, DOI 10.1002/lary.23473 Rosen CA, 2004, LARYNGOSCOPE, V114, P1549, DOI 10.1097/00005537-200409000-00009 SLAVIT DH, 1992, ANN OTO RHINOL LARYN, V101, P321 THOMPSON DM, 1995, LARYNGOSCOPE, V105, P481, DOI 10.1288/00005537-199505000-00006 THOMPSON DM, 1995, LARYNGOSCOPE, V105, P1148 Zeitels SM, 1998, ANN OTO RHINOL LARYN, V107, P2 NR 17 TC 0 Z9 0 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD MAY PY 2014 VL 123 IS 5 BP 347 EP 352 DI 10.1177/0003489414526367 PG 6 WC Otorhinolaryngology SC Otorhinolaryngology GA AG5YF UT WOS:000335494400008 PM 24668053 ER PT J AU Gallagher, KK Spector, ME Pepper, JP McKean, EL Marentette, LJ McHugh, JB AF Gallagher, Kelly K. Spector, Matthew E. Pepper, Jon-Paul McKean, Erin L. Marentette, Lawrence J. McHugh, Jonathan B. TI Esthesioneuroblastoma: Updating Histologic Grading as It Relates to Prognosis SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE esthesioneuroblastoma; olfactory neuroblastoma; grading; Hyams; histopathology ID OLFACTORY NEUROBLASTOMA; EXPERIENCE; MANAGEMENT AB Objective: The Hyams grading system has been extensively used to predict prognosis in patients with esthesioneuroblastoma (ENB). However, most studies showing prognostic correlation group grading into I/II versus III/IV, essentially comparing low versus high grade. In addition, these studies include patients with variable treatment regimens, including some that were treated with chemoradiation alone. We aimed to determine whether additional histologic variables correlate with outcome with regard to disease free and overall survival in a series of patients universally treated with anterior skull base resection and +/- adjuvant chemoradiation. Study Design: A retrospective review of 27 patients with ENB was performed. Methods: The sections of tumor from these 27 patients were studied and reviewed with attention to percentage lobularity, degree of pleomorphism, degree of neurofibrillary matrix, and degree of apoptosis. In addition, the presence or absence of rosettes, necrosis, calcification, spindle cells, gland hyperplasia, and bone invasion were noted. Finally, the number of mitoses per high power field and the nature of chromatin (fine vs coarse) were recorded. The histopathologic features of these 27 ENBs were reviewed and correlated with clinical outcome. Results: There were 11 patients with recurrence (40.7% recurrence). There were 5 deaths (81.5% survival). The study cohort's mean overall survival was 158 months and the mean disease-free survival was 70.6 months. In terms of overall survival, necrosis and mitosis (#/10hpf) were significant but not when multivariate analysis was performed, these were not individually significant. In terms of disease-free survival, mitosis (#/10hpf) was significant but not on multivariate analysis. Gland hyperplasia was found to be a positive prognostic variable, associated with longer overall and disease-free survival, but only in combination with no spindle features and without necrosis. Conclusions: An updated histologic grading system may provide more valuable prognostic information in patients with esthesioneuroblastoma treated with a standardized treatment paradigm. C1 [Gallagher, Kelly K.; Spector, Matthew E.; Pepper, Jon-Paul; McKean, Erin L.; Marentette, Lawrence J.] Univ Michigan Hlth Syst, Dept Otolaryngol Head & Neck Surg, Ann Arbor, MI 48109 USA. [McHugh, Jonathan B.] Univ Michigan Hlth Syst, Dept Pathol, Ann Arbor, MI 48109 USA. RP McHugh, JB (reprint author), Univ Michigan Hlth Syst, Dept Pathol, 2G322 Univ Hosp,1500 Med Ctr Dr, Ann Arbor, MI 48109 USA. EM jonamch@med.umich.edu CR Berger L, 1924, B ASS FRANC CANCER, V13, P410 Bradley Patrick J, 2003, Curr Opin Otolaryngol Head Neck Surg, V11, P112, DOI 10.1097/00020840-200304000-00009 Broich G, 1997, ANTICANCER RES, V17, P2683 Cohen Zvi R, 2002, Neurosurg Focus, V12, pe3 Constantinidis J, 2004, OTOLARYNG HEAD NECK, V130, P567, DOI 10.1016/j.otohns.2003.10.010 Dias FL, 2003, ARCH OTOLARYNGOL, V129, P1186, DOI 10.1001/archotol.129.11.1186 Diaz EM, 2005, HEAD NECK-J SCI SPEC, V27, P138, DOI 10.1002/hed.20127 Dulguerov P, 2001, LANCET ONCOL, V2, P683, DOI 10.1016/S1470-2045(01)00558-7 DULGUEROV P, 1992, LARYNGOSCOPE, V102, P843, DOI 10.1288/00005537-199208000-00001 FOOTE RL, 1993, INT J RADIAT ONCOL, V27, P835 HIROSE T, 1995, CANCER, V76, P4, DOI 10.1002/1097-0142(19950701)76:1<4::AID-CNCR2820760103>3.0.CO;2-E Hyams VJ, 1983, SPECIAL TUMORS HEAD, P24 Kane AJ, 2010, J NEUROSURG, V113, P340, DOI 10.3171/2010.2.JNS091897 Levine PA, 1999, LARYNGOSCOPE, V109, P1539, DOI 10.1097/00005537-199910000-00001 Miyamoto RC, 2000, LARYNGOSCOPE, V110, P1262 MORITA A, 1993, NEUROSURGERY, V32, P706 OBERMAN HA, 1976, CANCER, V38, P2494, DOI 10.1002/1097-0142(197612)38:6<2494::AID-CNCR2820380639>3.0.CO;2-U Oskouian Rod J Jr, 2002, Neurosurg Focus, V12, pe4 Polin RS, 1998, NEUROSURGERY, V42, P1029, DOI 10.1097/00006123-199805000-00045 Resto VA, 2000, HEAD NECK-J SCI SPEC, V22, P550, DOI 10.1002/1097-0347(200009)22:6<550::AID-HED2>3.0.CO;2-0 Thompson Lester D R, 2009, Head Neck Pathol, V3, P252, DOI 10.1007/s12105-009-0125-2 NR 21 TC 1 Z9 1 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD MAY PY 2014 VL 123 IS 5 BP 353 EP 358 DI 10.1177/0003489414526368 PG 6 WC Otorhinolaryngology SC Otorhinolaryngology GA AG5YF UT WOS:000335494400009 PM 24668054 ER PT J AU Angeli, SI Telischi, FF Eshraghi, AA AF Angeli, Simon I. Telischi, Fred F. Eshraghi, Adrien A. TI Middle Fossa Vestibular Neurectomy for Refractory Vertigo: Less Is More SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE cranial nerves; Meniere's disease; middle fossa craniotomy; saccule; VEMP; vertigo; vestibular; vestibular compensation; vestibular-evoked myogenic potentials; vestibular neurectomy ID MENIERES-DISEASE; GENTAMICIN AB Objective: This study aimed to evaluate outcomes of the middle fossa (MF) superior vestibular neurectomy in unilateral Meniere's disease. Patients and Methods: Case series with preoperative and postoperative analysis of the 1995 American Academy of Otolaryngology hearing stage and vertigo class, gait instability, and results of vestibular-evoked myogenic potentials (VEMP). Results: Four out of the 5 patients had total vertigo control (class A) and 1 had near total control (class B) by the last visit (mean follow-up, 23.6 months). There were no changes in hearing thresholds and hearing stage. Four patients had resolution of their gait instability by 2 months after surgery. Postoperative VEMP responses were preserved in all 3 patients with positive VEMP preoperatively. Conclusion: This is the first report of the anatomical and functional preservation of the inferior vestibular nerve in vestibular neurectomy for the treatment of refractory vertigo in unilateral Meniere's disease, with VEMP testing before and after vestibular neurectomy. The modified technique limits the surgical dissection and may help avoid complications such as postoperative hearing loss and persistent gait instability. This approach is indicated when other more conservative measures have failed, and patient selection is paramount to avoid long-term complications. C1 [Angeli, Simon I.; Telischi, Fred F.; Eshraghi, Adrien A.] Univ Miami, Miller Sch Med, Dept Otolaryngol, Miami, FL 33136 USA. RP Angeli, SI (reprint author), Univ Miami, Miller Sch Med, Dept Otolaryngol, Clin Res Bldg,1120 NW 14th St, Miami, FL 33136 USA. EM sangeli@med.miami.edu CR Allum JH, 2012, FRONT NEUROL, V3, P1 Angeli S, 2012, OTOLARYNG CLIN N AM, V45, P417, DOI 10.1016/j.otc.2011.12.010 [Anonymous], 1995, OTOLARYNGOL HEAD NEC, V113, P181 Blakley BW, 2000, LARYNGOSCOPE, V110, P236, DOI 10.1097/00005537-200002010-00009 Curthoys I S, 1995, J Vestib Res, V5, P67 Halmagyi GM, 1990, EXP BRAIN RES, V81, P471 Harner SG, 2001, OTOL NEUROTOL, V22, P210, DOI 10.1097/00129492-200103000-00016 HOUSE W F, 1961, Laryngoscope, V71, P1363 Lacour M, 2006, CURR MED RES OPIN, V22, P1651, DOI 10.1185/030079906X115694 Minor LB, 2004, CURR OPIN NEUROL, V17, P9, DOI 10.1097/01.wco.0000113944.12823.67 PAPANGEL.L, 1972, LARYNGOSCOPE, V82, P617, DOI 10.1288/00005537-197204000-00006 SANTOS PM, 1993, OTOLARYNG HEAD NECK, V109, P680 Thedinger BS, 1998, ENT-EAR NOSE THROAT, V77, P295 Thedinger B S, 1998, Ear Nose Throat J, V77, P290 Ulubil SA, 2008, LARYNGOSCOPE, V118, P295, DOI 10.1097/MLG.0b013e31815a05be VandeHeyning PH, 1997, ACTA OTO-LARYNGOL, P58 Yang TH, 2010, LARYNGOSCOPE, V120, P1910, DOI 10.1002/lary.21056 NR 17 TC 1 Z9 1 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD MAY PY 2014 VL 123 IS 5 BP 359 EP 364 DI 10.1177/0003489414526684 PG 6 WC Otorhinolaryngology SC Otorhinolaryngology GA AG5YF UT WOS:000335494400010 PM 24769882 ER PT J AU Flavill, E Fang, YSV Miles, B Truelson, J Perkins, S AF Flavill, Eric Fang, Yisheng V. Miles, Brett Truelson, John Perkins, Steve TI Induction Chemotherapy Followed by Concurrent Chemoradiotherapy for Advanced Stage Oropharyngeal Squamous Cell Carcinoma With HPV and P16 Testing SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE oropharyngeal squamous cell carcinoma; induction chemotherapy; sequential chemotherapy; human papilloma virus; p16 ID PHASE-III TRIAL; NECK-CANCER; HUMAN-PAPILLOMAVIRUS; RANDOMIZED-TRIAL; RADIATION-THERAPY; ADVANCED HEAD; CISPLATIN; FLUOROURACIL; RADIOTHERAPY; PACLITAXEL AB Objective: The objective was to report our experience with advanced stage oropharyngeal squamous cell carcinoma treated sequentially with induction chemotherapy followed by concurrent chemoradiotherapy. Methods: Retrospective chart review identified 49 eligible patients with advanced stage oropharyngeal squamous cell carcinoma treated with induction chemotherapy followed by concurrent chemoradiotherapy. HPV and p16(INK4A) testing was performed on pathology specimens. Follow-up of over 11 months was required unless a death or treatment failure occurred before that time. Results: Treatment with induction chemotherapy followed by concurrent chemoradiotherapy resulted in 44/48 (90%) complete durable response. One death occurred from pulmonary embolism. Toxicity profiles were comparable to other published data. Average follow-up was 3.9 years. Oncologic failure rates among subgroups showed 5.7% failure for HPV+/p16+ cancer, 9.1% failure for HPV-/p16+ cancer, 100% failure for HPV-/p16- cancer, 0% failure for nonsmokers, and 17.9% failure for smokers. Conclusions: This study showed favorable outcomes in terms of durable oncologic response and acceptable toxicity profiles. It is notable that 36/49 patients were HPV+/p16+ and 11/49 were HPV-/p16+. Only 2 patients were HPV-/p16-, and both died as a result of oncologic failures. This highlights the importance of obtaining HPV and p16 testing in studies evaluating the efficacy of treatments for oropharyngeal squamous cell carcinoma. C1 [Flavill, Eric; Miles, Brett; Truelson, John] Univ Texas Southwestern Med Ctr, Dept Otolaryngol Head & Neck Surg, Wilmington, OH 45177 USA. [Fang, Yisheng V.] Univ Texas SW Med Ctr Dallas, Dept Pathol, Dallas, TX 75390 USA. [Miles, Brett] Mt Sinai Hosp, New York, NY 10029 USA. [Perkins, Steve] Baylor Med Ctr, Dallas, TX USA. RP Flavill, E (reprint author), Univ Texas Southwestern Med Ctr, Dept Otolaryngol Head & Neck Surg, POB 72, Wilmington, OH 45177 USA. EM FlavillResearch@gmail.com FU American Airlines through the American Airlines Professorship in Cancer Research FX The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: Research was supported with funds from American Airlines through the American Airlines Professorship in Cancer Research. No sponsors or funders had any role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; or the preparation, review, or approval of the manuscript. CR Adelstein DJ, 2000, CANCER, V88, P876, DOI 10.1002/(SICI)1097-0142(20000215)88:4<876::AID-CNCR19>3.0.CO;2-Y Adelstein DJ, 2003, J CLIN ONCOL, V21, P92, DOI 10.1200/JCO.2003.01.008 Ang KK, 2010, NEW ENGL J MED, V363, P24, DOI 10.1056/NEJMoa0912217 Ang KK, 2011, J CLIN ONCOL S, V29, p360s Blanchard P, 2011, RADIOTHER ONCOL, V100, P33, DOI 10.1016/j.radonc.2011.05.036 Calais G, 1999, J NATL CANCER I, V91, P2081, DOI 10.1093/jnci/91.24.2081 Cohen EEW, 2012, J CLIN ONCOL, V30 Denis F, 2004, J CLIN ONCOL, V22, P69, DOI 10.1200/JCO.2004.08.021 Domenge C, 2000, BRIT J CANCER, V83, P1594, DOI 10.1054/bjoc.2000.1512 Forastiere AA, 1999, J NATL CANCER I, V91, P2065, DOI 10.1093/jnci/91.24.2065 Forastiere AA, 2003, NEW ENGL J MED, V349, P2091, DOI 10.1056/NEJMoa031317 Greven KM, 2008, AM J CLIN ONCOL-CANC, V31, P209, DOI 10.1097/COC.0b013e3181595b10 Haddad RI, 2012, J CLIN ONCOL, V30 Hancock SB, 2008, LARYNGOSCOPE, V118, P1357, DOI 10.1097/MLG.0b013e318175336a Hitt R, 2002, ANN ONCOL, V13, P1665, DOI 10.1093/annonc/mdf268 Kies MS, 2010, J CLIN ONCOL, V28, P8, DOI 10.1200/JCO.2009.23.0425 Kumar S, 1996, ACTA ONCOL, V35, P721 Lokich J, 1998, ANN ONCOL, V9, P13, DOI 10.1023/A:1008215213739 Lorch JH, 2011, LANCET ONCOL, V12, P153, DOI [10.1016/S1470-2045(10)70279-5, 10.1016/S1420-2045(10)20279-5] Paccagnella A, 2010, ANN ONCOL, V21, P1515, DOI 10.1093/annonc/mdp573 PACCAGNELLA A, 1994, J NATL CANCER I, V86, P265, DOI 10.1093/jnci/86.4.265 Pignon JP, 2009, RADIOTHER ONCOL, V92, P4, DOI 10.1016/j.radonc.2009.04.014 Posner M., 2006, OPTIONS TREATMENT HE Posner MR, 2007, NEW ENGL J MED, V357, P1705, DOI 10.1056/NEJMoa070956 Rischin D, 2010, J CLIN ONCOL, V28, P4142, DOI 10.1200/JCO.2010.29.2904 Vermorken JB, 2007, NEW ENGL J MED, V357, P1695, DOI 10.1056/NEJMoa071028 Vokes EE, 2003, J CLIN ONCOL, V21, P320, DOI 10.1200/JCO.2003.06.006 Weinberger PM, 2009, OTOLARYNG HEAD NECK, V141, P382, DOI 10.1016/j.otohns.2009.04.014 Weinberger PM, 2006, J CLIN ONCOL, V24, P736, DOI 10.1200/JCO.2004.00.3335 NR 29 TC 0 Z9 0 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD MAY PY 2014 VL 123 IS 5 BP 365 EP 373 DI 10.1177/0003489414526685 PG 9 WC Otorhinolaryngology SC Otorhinolaryngology GA AG5YF UT WOS:000335494400011 PM 24687594 ER PT J AU Keereweer, S Van der Schroeff, MP Pullens, B AF Keereweer, Stijn Van der Schroeff, Marc P. Pullens, Bas TI Case Report: Traumatic Displacement of a Cochlear Implant Magnet SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE cochlear implant; traumatic displacement AB Objectives: To date, over 200 000 cochlear implants (CIs) have been implanted worldwide and the incidence is still increasing. We present a case of traumatic displacement of CI magnet to raise awareness about this complication and to highlight the need for vigilance during surgery as well as for proper counseling. Methods: The clinical presentation of a 1.5-year-old boy with a traumatic displacement of a CI magnet was presented and the literature was reviewed for this rare complication. Results: After minor head injury, the sound processor could no longer connect to the CI. X-ray imaging demonstrated displacement of the CI magnet. During revision surgery, the magnet was replaced by a new magnet in the silicon holding cap. Intraoperative impedance measurements were normal and the CI was successfully activated 4 weeks postoperatively. Conclusions: Clinicians and patients should be aware of the risk of displacement of the CI magnet after (minor) head injury. Young boys tend to have a higher risk for this complication. C1 [Keereweer, Stijn; Van der Schroeff, Marc P.; Pullens, Bas] Sophia Childrens Univ Hosp, Erasmus Med Ctr, Dept Otorhinolaryngol, NL-3015 CE Rotterdam, Netherlands. RP Keereweer, S (reprint author), Sophia Childrens Univ Hosp, Erasmus Med Ctr, Dept Otorhinolaryngol, S Gravendijkwal 230, NL-3015 CE Rotterdam, Netherlands. EM s.keereweer@erasmusmc.nl CR Deneuve S, 2008, OTOL NEUROTOL, V29, P789, DOI 10.1097/MAO.0b013e3181825695 Loundon N, 2010, ARCH OTOLARYNGOL, V136, P12, DOI 10.1001/archoto.2009.187 Yun JM, 2005, OTOLARYNG HEAD NECK, V133, P275, DOI 10.1016/j.otohns.2005.02.018 NR 3 TC 1 Z9 1 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD APR PY 2014 VL 123 IS 4 BP 229 EP 231 DI 10.1177/0003489414525922 PG 3 WC Otorhinolaryngology SC Otorhinolaryngology GA AG5YD UT WOS:000335494100001 PM 24671476 ER PT J AU Gantwerker, EA Hamilton, SS Casper, KA AF Gantwerker, Eric A. Hamilton, Steven S. Casper, Keith A. TI A Fish Way Out of Water: Case Report of a Unique Airway Foreign Body SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE airway control; airway management; airway obstruction; bronchoscopy/methods; foreign bodies/surgery AB Background: Since the time of Chevalier Jackson, innumerable unique foreign bodies have been documented and removed. Advances in endoscopic airway management have revolutionized the types of foreign bodies that we are able to remove without open surgery. The literature on fish aspiration has mostly encompassed fish bones and parts, not whole live fish. Objective: This study aimed to describe the airway management of a high-risk airway foreign body including the mobilization and coordination of multiple specialty teams and anesthetic management. Case Report: We report a case of a 40-year-old man who aspirated a live bluegill fish while attempting to use it as bait. The spike-like nature of the bluegill dorsal fin in conjunction with mediastinal air prompted a higher level of concern for potential airway compromise and complication with extraction. We detail the preparation and management of this patient from notification to transportation and ultimately operative intervention. Focus is placed on coordination between anesthesia, otolaryngology, and cardiothoracic surgery, and the key management decisions. Conclusion: High-risk airway foreign bodies are always a challenge. When dealing with a live, lodged whole fish, one must have creative management ideas. Close coordination and excellent communication must occur between teams involved to optimize and maintain control of the situation for the best patient outcome. C1 [Gantwerker, Eric A.; Hamilton, Steven S.; Casper, Keith A.] Univ Cincinnati, Dept Otolaryngol Head & Neck Surg, Cincinnati, OH 45267 USA. [Gantwerker, Eric A.; Hamilton, Steven S.] Cincinnati Childrens Hosp Med Ctr, Cincinnati, OH 45267 USA. RP Gantwerker, EA (reprint author), Univ Cincinnati, Dept Otolaryngol Head & Neck Surg, POB 670528, Cincinnati, OH 45267 USA. EM eric.gantwerker@gmail.com CR Fidkowski CW, 2010, ANESTH ANALG, V111, P1016, DOI 10.1213/ANE.0b013e3181ef3e9c SPARKS DL, 1975, ANESTH ANALG, V54, P189 Zur KB, 2009, PEDIATR ANESTH, V19, P109, DOI 10.1111/j.1460-9592.2009.03006.x NR 3 TC 0 Z9 0 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD APR PY 2014 VL 123 IS 4 BP 232 EP 234 DI 10.1177/0003489414524167 PG 3 WC Otorhinolaryngology SC Otorhinolaryngology GA AG5YD UT WOS:000335494100002 PM 24671477 ER PT J AU McRackan, TR Fang, TY Pelosi, S Rivas, A Dietrich, MS Wanna, GB Labadie, RF Haynes, DS Bennett, ML AF McRackan, Theodore R. Fang, Te-Yung Pelosi, Stanley Rivas, Alejandro Dietrich, Mary S. Wanna, George B. Labadie, Robert F. Haynes, David S. Bennett, Marc L. TI Factors Associated With Recurrence of Squamous Cell Carcinoma Involving the Temporal Bone SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE cranial base malignancy; head and neck cancer; salivary gland malignancy; skull base surgery; temporal bone resection ID STAGING SYSTEM; MIDDLE-EAR; RESECTION; SURGERY; CANCER AB Objective: This study aimed to better identify factors associated with recurrence of squamous cell carcinoma (SCC) involving the temporal bone. Methods: A retrospective study was conducted at a tertiary hospital. Sixty patients who were diagnosed over a 10-year period with SCC involving the temporal bone and underwent surgical resection were analyzed. All patients were staged based on the University of Pittsburgh staging system. Demographic, intraoperative, and pathologic data were analyzed with respect to recurrence. Results: Thirteen (21.7%) patients were T1, 8 (13.3%) T2, 7 (11.7%) T3, and 32 (53.3%) T4. Eighteen patients (30.0%) recurred in the study period. The mean time to recurrence was 5.8 months. Tumors originating in the skin overlying the parotid gland and the external auditory canal had higher recurrence rates than those from the auricle/postauricular skin and temporal bone (P = .05). Direct parotid and perineural spread accounted for 15.0% of all routes of temporal invasion but resulted in 22.2% of all recurrences (P = .04). Increased N stage was statistically associated with increased risk of recurrence (P = .01). Cervical, as compared to perifacial and parotid, lymph node involvement was associated with increased risk of recurrence (odds ratio = 6.91; 95% confidence interval, 1.11-42.87). Conclusion: We have identified multiple factors that are associated with increased recurrence of SCC involving the temporal bone. C1 [McRackan, Theodore R.; Fang, Te-Yung; Pelosi, Stanley; Rivas, Alejandro; Wanna, George B.; Labadie, Robert F.; Haynes, David S.; Bennett, Marc L.] Vanderbilt Univ, Med Ctr, Dept Otolaryngol Head & Neck Surg, Nashville, TN 37232 USA. [Dietrich, Mary S.] Vanderbilt Univ, Med Ctr, Sch Med & Nursing, Dept Biostat, Nashville, TN 37232 USA. RP Bennett, ML (reprint author), Vanderbilt Univ, Med Ctr, Dept Otolaryngol Head & Neck Surg, 1215 21st Ave South,Suite 7209 Med Ctr East, Nashville, TN 37232 USA. EM Marc.bennett@vanderbilt.edu CR ARRIAGA M, 1990, ANN OTO RHINOL LARYN, V99, P714 AUSTIN JR, 1994, ARCH OTOLARYNGOL, V120, P1228 Backous DD, 2005, LARYNGOSCOPE, V115, P931, DOI 10.1097/01.MLG.0000163766.66223.97 Dean NR, 2010, LARYNGOSCOPE, V120, P1516, DOI 10.1002/lary.20999 Gidley PW, 2012, LARYNGOSCOPE, V122, P393, DOI 10.1002/lary.22402 Gidley PW, 2011, LARYNGOSCOPE, V121, P1702, DOI 10.1002/lary.21867 Gillespie MB, 2001, ARCH OTOLARYNGOL, V127, P803 Hirsch BE, 2002, ARCH OTOLARYNGOL, V128, P93 Mantravadi AV, 2011, OTOLARYNG HEAD NECK, V144, P395, DOI 10.1177/0194599810393880 Moffat DA, 2005, LARYNGOSCOPE, V115, P341, DOI 10.1097/01.mlg.0000154744.71184.c7 Moffat DA, 1997, OTOLARYNG HEAD NECK, V116, P617, DOI 10.1016/S0194-5998(97)70237-7 Moody SA, 2000, AM J OTOL, V21, P582 Morris LGT, 2012, HEAD NECK-J SCI SPEC, V34, P1231, DOI 10.1002/hed.21883 MORTON RP, 1984, CANCER, V53, P1612, DOI 10.1002/1097-0142(19840401)53:7<1612::AID-CNCR2820530733>3.0.CO;2-P Nakagawa T, 2006, OTOL NEUROTOL, V27, P242, DOI 10.1097/01.mao.0000190463.88873.3d PRASAD S, 1994, OTOLARYNG HEAD NECK, V110, P270, DOI 10.1016/S0194-5998(94)70769-3 Zhang B, 1999, HEAD NECK-J SCI SPEC, V21, P461, DOI 10.1002/(SICI)1097-0347(199908)21:5<461::AID-HED13>3.0.CO;2-L NR 17 TC 0 Z9 0 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD APR PY 2014 VL 123 IS 4 BP 235 EP 239 DI 10.1177/0003489414524169 PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA AG5YD UT WOS:000335494100003 PM 24671478 ER PT J AU Kim, JH Cho, GS Cheang, PP Jang, YJ AF Kim, Ji Heui Cho, Gye Song Cheang, Pei-Pei Jang, Yong Ju TI The Effects of Endoscopic Sinus Surgery on the Postoperative Outcomes of Open Rhinoplasty SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE chronic rhinosinusitis; endoscopic sinus surgery; outcome; rhinoplasty; treatment ID CONCURRENT RHINOPLASTY AB Objective: Several studies have advocated concurrent endoscopic sinus surgery and rhinoplasty. However, concerns about increased surgical risk, complications, and unsuccessful cosmetic outcomes following the concurrent procedures have been reported. The aim of this study was to investigate the overall safety of concurrent endoscopic sinus surgery and rhinoplasty and to specifically examine the effect of endoscopic sinus surgery on cosmetic outcomes. Methods: We retrospectively reviewed 57 patients who underwent concurrent open rhinoplasty and endoscopic sinus surgery (ESS). We then selected a control group of patients, who underwent rhinoplasty only and were matched with a study group for age, sex, external nose deformity, and implant graft material. The postoperative outcomes of the 2 groups were compared. Results: Fifty-seven patients underwent concurrent open rhinoplasty and ESS. Postoperative assessment showed that a successful outcome was achieved in 82.5% of the patients who underwent concurrent procedures and in 87.7% of the patients who underwent rhinoplasty only (P = .56). The rate of revision due to a dissatisfied outcome was 5 patients (8.7%) in the concurrent surgery group and 3 patients (5.3%) in the rhinoplasty-only group (P = .36). Minor complications occurred in 6 patients (10.5%) from the group who underwent the concurrent procedures and 5 patients (8.8%) from the rhinoplasty-only group (P = .76). Conclusion: Combined rhinoplasty and endoscopic sinus surgery achieves a similar aesthetic outcome to rhinoplasty only, with no significant increase in rates of revision or complication. C1 [Kim, Ji Heui; Cho, Gye Song; Cheang, Pei-Pei; Jang, Yong Ju] Univ Ulsan, Coll Med, Asan Med Ctr, Dept Otolaryngol, Seoul 138736, South Korea. RP Jang, YJ (reprint author), Univ Ulsan, Coll Med, Asan Med Ctr, Dept Otolaryngol, 88 Olymp Ro 43-Gil, Seoul 138736, South Korea. EM jangyj@amc.seoul.kr CR Cho GS, 2013, LARYNGOSCOPE, V123, P1136, DOI 10.1002/lary.23195 Fakhri Samer, 2004, Facial Plast Surg Clin North Am, V12, P431, DOI 10.1016/j.fsc.2004.04.005 Friedman WH, 1999, FACIAL PLAST SURG CL, V7, P357 Inanli S, 2008, J CRANIOFAC SURG, V19, P701, DOI 10.1097/SCS.0b013e3180690182 Jang YJ, 2007, OTOLARYNG HEAD NECK, V137, P88, DOI 10.1016/j.otohns.2007.01.009 Jang YJ, 2011, J PLAST RECONSTR AES, V64, P301, DOI 10.1016/j.bjps.2010.05.032 Kircher ML, 2006, AM J RHINOL, V20, P485, DOI 10.2500/ajr.2006.20.2933 Lee JH, 2005, OTOLARYNG HEAD NECK, V133, P436, DOI 10.1016/j.otohns.2005.04.010 Lund Valerie J., 1993, Rhinology (Utrecht), V31, P183 Marcus B, 2006, ARCH FACIAL PLAST S, V8, P260, DOI 10.1001/archfaci.8.4.260 Mazzola RF, 2005, PLAST RECONSTR SURG, V115, P705, DOI 10.1097/01.PRS.0000152430.89225.F8 Millman B, 2002, LARYNGOSCOPE, V112, P1193, DOI 10.1097/00005537-200207000-00009 Murrell G, 2011, FACIAL PLAST SURG CL, V2011 Reh DD, 2012, FACIAL PLAST SURG CL, V20, P43, DOI 10.1016/j.fsc.2011.10.005 Rizk SS, 1997, ANN PLAS SURG, V38, P323, DOI 10.1097/00000637-199704000-00003 Sclafani AR, 2009, LARYNGOSCOPE, V119, P778, DOI 10.1002/lary.20098 Shemen L, 1991, AM J RHINOL, V5, P131, DOI 10.2500/105065891781874965 Toffel P, 1994, ENT-EAR NOSE THROAT, V73, P556 NR 18 TC 2 Z9 2 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD APR PY 2014 VL 123 IS 4 BP 240 EP 246 DI 10.1177/0003489414524172 PG 7 WC Otorhinolaryngology SC Otorhinolaryngology GA AG5YD UT WOS:000335494100004 PM 24671479 ER PT J AU Shimazu, R Kuratomi, Y Aoki, S Inokuchi, A AF Shimazu, Rintaro Kuratomi, Yuichiro Aoki, Shigehisa Inokuchi, Akira TI Laryngeal Granuloma in Experimental Rats With Gastroesophageal Reflux Disease and Mechanically Injured Vocal Cord Mucosa SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE larynx; laryngeal granuloma; LPRD; GERD ID ESOPHAGITIS AB Objective: This study was undertaken to elucidate the mechanisms underlying laryngeal granuloma formation in a rat model of gastroesophageal reflux disease (GERD) with mechanically injured vocal cord mucosa. Methods: The rat model of GERD was surgically created by tying the pyloric sphincter and ligating the transitional region between the forestomach and the glandular portion (limiting ridge). The control rats received only a midline incision. In all the animals, a plastic bar was inserted into the trachea, and moved vertically thrice in 3 seconds to cause mechanical injury of the vocal cord mucosa. The rats were sacrificed 2 weeks postsurgically, and their pharynx and larynx were observed histologically. Results: Granulomas were observed in the vocal cord mucosa of the GERD group (3 of 5 animals); they presented a similar pathological structure to that of human laryngeal granulomas. In contrast, only abrasions and blisters were observed on the vocal cord mucosa in the control group (all 5 animals). Conclusions: The development of laryngeal granuloma may involve both mechanical injury and gastric acid reflux. C1 [Shimazu, Rintaro; Kuratomi, Yuichiro; Inokuchi, Akira] Saga Univ, Fac Med, Dept Otolaryngol Head & Neck Surg, Saga 8498501, Japan. [Aoki, Shigehisa] Saga Univ, Fac Med, Dept Pathol & Microbiol, Saga 8498501, Japan. RP Shimazu, R (reprint author), Saga Univ, Fac Med, Dept Otolaryngol Head & Neck Surg, 5-1-1 Nabeshima, Saga 8498501, Japan. EM shimazu@cc.saga-u.ac.jp CR Asaoka D, 2011, DIGEST DIS SCI, V56, P1299, DOI 10.1007/s10620-010-1431-y DELAHUNT.JE, 1968, LARYNGOSCOPE, V78, P1941, DOI 10.1288/00005537-196811000-00008 HOLINGER PH, 1960, JAMA-J AM MED ASSOC, V172, P511 Omura N, 1999, SCAND J GASTROENTERO, V34, P948 Shimazu R, 2009, ACTA OTO-LARYNGOL, V129, P886, DOI 10.1080/00016480802468161 SVENSSON G, 1988, ACTA OTO-LARYNGOL, P123 Tauber S, 2002, LARYNGOSCOPE, V112, P879, DOI 10.1097/00005537-200205000-00019 WENIG BM, 1990, ARCH PATHOL LAB MED, V114, P825 NR 8 TC 0 Z9 0 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD APR PY 2014 VL 123 IS 4 BP 247 EP 251 DI 10.1177/0003489414525018 PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA AG5YD UT WOS:000335494100005 PM 24671480 ER PT J AU Silver, N Gal, TJ AF Silver, Natalie Gal, T. J. TI Endoscopic CO2 Laser Management of Chemoradiation-related Cricopharyngeal Stenosis SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE dysphagia; chemoradiation; cricopharyngeal stenosis; myotomy; carbon dioxide laser ID NECK-CANCER; RADIATION-THERAPY; ESOPHAGEAL STRICTURES; HEAD; CHEMOTHERAPY; MYOTOMY; LASER; DYSFUNCTION; DILATION; SURGERY AB Objective: Treatment of head and neck cancer with chemoradiation (CRT) can result in strictures of the cervical esophagus, often at the level of the cricopharyngeus. The objective of this study is to assess the feasibility of endoscopic CO2 laser cricopharyngeal myotomy for stricture ablation in the setting of prior CRT. Methods: A retrospective review of patients who underwent endoscopic CO2 laser cricopharyngeal myotomy for dysphagia after radiation for squamous cell carcinoma of the head and neck (SCCHN). Pre- and postoperative barium swallow and swallowing assessment were performed before and after surgery. Outcomes and complication rates were examined. Results: Endoscopic CO2 laser cricopharyngeal myotomy was performed in 10 patients with dysphagia secondary to cricopharyngeal stenosis/stricture, which developed following treatment for SCCHN with chemoradiation. All patients demonstrated radiographic improvement in stricture, with complete resolution of stricture in 9 of 10 patients. All patients noted improvement in dysphagia with 9 of 10 patients demonstrating significant advancement of diet by modified barium swallow. No complications were observed. Conclusion: Endoscopic CO2 cricopharyngeal myotomy can be performed safely in the setting of prior CRT, with significant improvement in swallowing in select patients. Indications and technical considerations will be discussed. C1 [Silver, Natalie; Gal, T. J.] Univ Kentucky, Dept Otolaryngol, Lexington, KY 40536 USA. RP Silver, N (reprint author), Univ Kentucky, Dept Otolaryngol, 800 Rose St C236, Lexington, KY 40536 USA. EM natalie.silver@uky.edu CR Abdel-Wahab M, 2005, AM J CLIN ONCOL-CANC, V28, P371 Abdel-Wahab M, 2005, AM J CLIN ONCOL-CANC, V28, P359, DOI 10.1097/01.coc.0000158837.47450.81 Ahlawat SK, 2008, GASTROINTEST ENDOSC, V68, P19, DOI 10.1016/j.gie.2007.11.027 Chapuy CI, 2013, LARYNGOSCOPE, V123, P3066, DOI 10.1002/lary.24268 Dhir V, 1996, J SURG ONCOL, V63, P187, DOI 10.1002/(SICI)1096-9098(199611)63:3<187::AID-JSO10>3.0.CO;2-2 Eisbruch A, 2002, INT J RADIAT ONCOL, V53, P23, DOI 10.1016/S0360-3016(02)02712-8 Francis DO, 2010, ANN OTO RHINOL LARYN, V119, P391 Guadagnolo BA, 2005, AM J CLIN ONCOL-CANC, V28, P371, DOI 10.1097/01.coc.0000162423.13431.8d HALVORSON DJ, 1994, ANN OTO RHINOL LARYN, V103, P173 Hu HT, 2010, AM J ROENTGENOL, V194, P1131, DOI 10.2214/AJR.09.3345 KAPLAN S, 1951, ANN SURG, V133, P572, DOI 10.1097/00000658-195113340-00021 KOZAREK RA, 1984, J CLIN GASTROENTEROL, V6, P505, DOI 10.1097/00004836-198412000-00004 Lawson G, 2003, EUR ARCH OTO-RHINO-L, V260, P475, DOI 10.1007/s00405-003-0605-z Lawson Georges, 2006, Curr Opin Otolaryngol Head Neck Surg, V14, P437, DOI 10.1097/MOO.0b013e3280106314 Lawson JD, 2008, AM J OTOLARYNG, V29, P13, DOI 10.1016/j.amjoto.2006.12.002 Peretti G, 2010, ACTA OTORHINOLARYNGO, V30, P1 Pitman M, 2009, LARYNGOSCOPE, V119, P45, DOI 10.1002/lary.20032 Takes RP, 2005, HEAD NECK-J SCI SPEC, V27, P703, DOI 10.1002/hed.20201 NR 18 TC 0 Z9 0 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD APR PY 2014 VL 123 IS 4 BP 252 EP 256 DI 10.1177/0003489414525019 PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA AG5YD UT WOS:000335494100006 PM 24595625 ER PT J AU Eadie, TL Lamvik, K Baylor, CR Yorkston, KM Kim, J Amtmann, D AF Eadie, Tanya L. Lamvik, Kristin Baylor, Carolyn R. Yorkston, Kathryn M. Kim, Jiseon Amtmann, Dagmar TI Communicative Participation and Quality of Life in Head and Neck Cancer SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE communication; head and neck cancer; outcome measures; quality of life; speech ID INTERNATIONAL CLASSIFICATION; HANDICAP INDEX; HEALTH; INSTRUMENTS; SURVIVORS; SPEECH; QUESTIONNAIRE; VALIDATION; DISABILITY; DISORDERS AB Objective: The purpose of this study was to determine how a new self-report outcome measure of communicative participation, the Communicative Participation Item Bank (CPIB), related to disease-and discipline-specific quality of life (QOL) outcomes in a head and neck cancer (HNC) population. Methods: One hundred ninety-five individuals treated for HNC completed the CPIB, the University of Washington Quality of Life questionnaire (UW-QOL), and the Voice Handicap Index-10 (VHI-10). Results: Results revealed moderate QOL scores across the UW-QOL (mean scores: global QOL = 66; physical subscale = 70; social-emotional subscale = 73) and VHI-10 (mean = 16). Correlations between the CPIB and the UW-QOL scores were statistically significant (P < .001) but relatively weak (r = .37-.38). As hypothesized, a stronger correlation was found between the CPIB and the VHI-10 (r = -0.79; P < .001). Conclusion: Clinicians may consider adopting the CPIB to complement existing tools in assessing communication outcomes after HNC. C1 [Eadie, Tanya L.; Lamvik, Kristin] Univ Washington, Dept Speech & Hearing Sci, Seattle, WA 98105 USA. [Baylor, Carolyn R.; Yorkston, Kathryn M.; Kim, Jiseon; Amtmann, Dagmar] Univ Washington, Dept Rehabil Med, Seattle, WA 98195 USA. RP Eadie, TL (reprint author), Univ Washington, Dept Speech & Hearing Sci, 1417 NE 42nd St, Seattle, WA 98105 USA. EM teadie@u.washington.edu FU National Institutes of Health/National Cancer Institute [1R03CA132525-01A1]; National Institute on Deafness and Other Communication Disorders [1R03DC010044] FX The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: National Institutes of Health/National Cancer Institute (1R03CA132525-01A1; PI: Eadie) and National Institute on Deafness and Other Communication Disorders (1R03DC010044; PI: Baylor). CR Baylor C, 2013, J SPEECH LANG HEAR R, V56, P1190, DOI 10.1044/1092-4388(2012/12-0140) Baylor C, 2011, AM J SPEECH-LANG PAT, V20, P269, DOI 10.1044/1058-0360(2011/10-0084) Baylor CR, 2009, J SPEECH LANG HEAR R, V52, P1302, DOI 10.1044/1092-4388(2009/07-0275) Bjordal K, 1999, J CLIN ONCOL, V17, P1008 Bjordal K, 1995, Eur J Cancer B Oral Oncol, V31B, P235, DOI 10.1016/0964-1955(95)00010-F Blood G, 1993, AM J SPEECH-LANG PAT, V2, P82 Campbell BH, 2000, LARYNGOSCOPE, V110, P895, DOI 10.1097/00005537-200006000-00003 Eadie TL, 2006, AM J SPEECH-LANG PAT, V15, P307, DOI 10.1044/1058-0360(2006/030) El-Deiry MW, 2009, ARCH OTOLARYNGOL, V135, P380, DOI 10.1001/archoto.2009.18 Evans E, 2009, INT J LANG COMM DIS, V44, P575, DOI 10.1080/13682820902928729 Franic DM, 2005, J VOICE, V19, P300, DOI 10.1016/j.jvoice.2004.03.003 Frost MH, 2007, VALUE HEALTH, V10, pS94, DOI 10.1111/j.1524-4733.2007.00272.x Funk GF, 2012, ARCH OTOLARYNGOL, V138, P123, DOI 10.1001/archoto.2011.234 HASSAN SJ, 1993, HEAD NECK-J SCI SPEC, V15, P485, DOI 10.1002/hed.2880150603 Hays R, 2000, MED CARE S, V38, pS28 Karnell LH, 2000, HEAD NECK-J SCI SPEC, V22, P6, DOI 10.1002/(SICI)1097-0347(200001)22:1<6::AID-HED2>3.0.CO;2-P Li C, 2011, IRTPRO Op de Coul BM, 2005, CLIN OTOLARYNGOL, V30, P169 Oridate N, 2009, ARCH OTOLARYNGOL, V135, P363, DOI 10.1001/archoto.2009.8 Ringash J, 2007, CANCER, V110, P196, DOI 10.1002/cncr22799 Rinkel RN, 2008, HEAD NECK-J SCI SPEC, V30, P868, DOI 10.1002/hed.20795 Rogers SN, 2010, ARCH OTOLARYNGOL, V136, P352, DOI 10.1001/archoto.2010.32 Rogers SN, 2002, HEAD NECK-J SCI SPEC, V24, P521, DOI 10.1002/hed.10106 Rosen CA, 2004, LARYNGOSCOPE, V114, P1549, DOI 10.1097/00005537-200409000-00009 Samejima F, 1969, PSYCHOMETRIKA MONOGR, V17 Thomas L, 2009, CLIN OTOLARYNGOL, V34, P34, DOI 10.1111/j.1749-4486.2008.01830.x Tschiesner U, 2009, LARYNGOSCOPE, V119, P915, DOI 10.1002/lary.20211 Tschiesner U, 2008, EUR ARCH OTO-RHINO-L, V265, P627, DOI 10.1007/s00405-008-0641-9 Tschiesner U, 2010, HEAD NECK-J SCI SPEC, V32, P210, DOI 10.1002/hed.21172 van der Mei SF, 2011, QUAL LIFE RES, V20, P1617, DOI 10.1007/s11136-011-9900-0 NR 30 TC 1 Z9 1 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD APR PY 2014 VL 123 IS 4 BP 257 EP 264 DI 10.1177/0003489414525020 PG 8 WC Otorhinolaryngology SC Otorhinolaryngology GA AG5YD UT WOS:000335494100007 PM 24671481 ER PT J AU Patel, AK Mildenhall, NR Kim, W Carroll, TL AF Patel, Anju K. Mildenhall, Nicholas R. Kim, William Carroll, Thomas L. TI Symptom Overlap Between Laryngopharyngeal Reflux and Glottic Insufficiency in Vocal Fold Atrophy Patients SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE dysphonia; glottic insufficiency; laryngopharyngeal reflux; presbylarynx; proton pump inhibitors; vocal fold atrophy ID MUSCLE TENSION DYSPHONIA; VOICE DISORDERS; LARYNGEAL AB Objective: To determine in true vocal fold (TVF) atrophy patients if symptoms of throat clearing and mucus sensation, attributed to laryngopharyngeal reflux (LPR), are due to glottic insufficiency. Is the TVF atrophy population being prescribed proton pump inhibitors unnecessarily? Methods: A retrospective review of patients with TVF atrophy but no other underlying laryngeal pathology seen at a tertiary voice center from July 2009 to May 2012 was conducted. Patient demographics, symptoms, LPR diagnosis, interventions, and pre-intervention and post-intervention Voice Handicap Index-10 (VHI) and Reflux Symptom Index (RSI) scores were recorded. Results: Twenty-six patients met inclusion criteria, and 85% were treated for LPR. Throat clearing and mucus sensation (85%), dysphonia (54%), and globus sensation (46%) were recorded. Interventions included LPR medical management (65%), vocal fold augmentation (23%), and voice therapy (12%). Reflux Symptom Index scores improved in all groups. Voice Handicap Index-10 and RSI scores normalized in patients treated with augmentation. Globus was never present in patients who received augmentation. Conclusion: Throat clearing and mucus sensation may be due to underlying glottic insufficiency and changes of the aging larynx rather than LPR. High VHI and RSI scores normalized with TVF augmentation. Further work is needed to evaluate symptom presentation and risk versus benefit of treatment options, especially if it avoids unnecessary proton pump inhibitor trials. C1 [Patel, Anju K.; Carroll, Thomas L.] Tufts Med Ctr, Dept Otolaryngol, Boston, MA 02111 USA. [Mildenhall, Nicholas R.; Kim, William] Tufts Univ, Sch Med, Boston, MA 02111 USA. RP Carroll, TL (reprint author), Tufts Med Ctr, Dept Otolaryngol, 800 Washington St,Box 850, Boston, MA 02111 USA. EM tcarroll@tuftsmedicalcenter.org FU National Center for Research Resources [UL1 RR025752]; National Center for Advancing Translational Sciences, National Institutes of Health [UL1 TR000073] FX The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: The project described was supported by the National Center for Research Resources Grant No. UL1 RR025752 and the National Center for Advancing Translational Sciences, National Institutes of Health, Grant No. UL1 TR000073. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. CR Altman KW, 2005, J VOICE, V19, P261, DOI 10.1016/j.jvoice.2004.03.007 Belafsky PC, 2002, J VOICE, V16, P274, DOI 10.1016/S0892-1997(02)00097-8 Belafsky PC, 2002, OTOLARYNG HEAD NECK, V127, P448, DOI 10.1067/mhn.2002.128894 Carroll TL, 2010, LARYNGOSCOPE, V120, P114, DOI 10.1002/lary.20656 Carroll TL, 2012, J VOICE, V26, P220, DOI 10.1016/j.jvoice.2011.01.008 Cohen SM, 2008, LARYNGOSCOPE, V118, P363, DOI 10.1097/MLG.0b013e318158f72d Davids T, 2012, LARYNGOSCOPE, V122, P332 Gartner-Schmidt J, 2011, LARYNGOSCOPE, V121, P585, DOI 10.1002/lary.21122 Gregory ND, 2012, J VOICE, V26, P254, DOI 10.1016/j.jvoice.2010.10.024 Koufman JA, 2000, OTOLARYNG HEAD NECK, V123, P385, DOI 10.1067/mhn.2000.109935 Pontes P, 2005, J VOICE, V19, P84, DOI 10.1016/j.jvoice.2004.09.002 Rees CJ, 2009, ANN OTO RHINOL LARYN, V118, P247 Reulbach TR, 2001, OTOLARYNG HEAD NECK, V124, P448, DOI 10.1067/mhn.2001.114256 Sato K, 1997, ANN OTO RHINOL LARYN, V106, P44 Woo P, 1992, Laryngoscope, V102, P139 Yu EW, 2011, AM J MED, V124, P519, DOI 10.1016/j.amjmed.2011.01.007 NR 16 TC 1 Z9 1 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD APR PY 2014 VL 123 IS 4 BP 265 EP 270 DI 10.1177/0003489414525021 PG 6 WC Otorhinolaryngology SC Otorhinolaryngology GA AG5YD UT WOS:000335494100008 PM 24671482 ER PT J AU Croake, DJ Stemple, JC Uhl, T Archer, S Andreatta, RD AF Croake, Daniel J. Stemple, Joseph C. Uhl, Timothy Archer, Sanford Andreatta, Richard D. TI Reliability of Clinical Office-Based Laryngeal Electromyography in Vocally Healthy Adults SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE LEMG; motor units; neuromuscular; thyroarytenoid ID QUANTITATIVE-ANALYSIS; FOLD PARALYSIS; PARESIS; EMG AB Objective: This study aimed to conduct a 3-session reliability assessment of the laryngeal electromyography (LEMG) signal in healthy participants during intensity controlled vocalization tasks. We hypothesized that vocal intensity level and testing session would affect LEMG measures. Methods: This prospective study used a 2-factor repeated measures design. Seven participants underwent bipolar needle LEMG of the right thyroarytenoid muscle. Data were collected over 3 testing sessions using vocalization tasks performed with visually guided intensity feedback targets (65 and 75 dB SPL). Root mean square amplitudes in microvolts were analyzed for within-session and between-session reliability. Results: The main effect for intensity was found to approach significance (F = 5.71, P = .054). However, intraclass correlation coefficients (ICCs) using a 2-factor mixed random effect model indicated poor to fair signal reliability between testing sessions (ICC = 0.56 at 65 dB, 0.40 at 70 dB). Intraclass correlation coefficients for within-session data indicated excellent reliability for all testing conditions (0.84-0.98). Conclusion: Using a quantitative analysis protocol to inform an essentially qualitative technique, our results indicated that there was generally poor to fair reliability in the LEMG signal over testing sessions. Vocal intensity was an important variable that affected LEMG signal reliability. Standardization of LEMG protocols using vocal control parameters and quantitative analyses may help improve LEMG reliability in clinical settings. C1 [Croake, Daniel J.; Stemple, Joseph C.; Uhl, Timothy; Andreatta, Richard D.] Univ Kentucky, Coll Hlth Sci, Lexington, KY 40536 USA. [Archer, Sanford] Univ Kentucky, Coll Med, Lexington, KY 40536 USA. RP Croake, DJ (reprint author), Univ Kentucky, Coll Hlth Sci, Dept Rehabil Sci, Room 120H Wethington Bldg,900 South Limestone St, Lexington, KY 40536 USA. EM djcroa2@uky.edu FU University of Kentucky College of Health Sciences Office of Research FX The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: The University of Kentucky College of Health Sciences Office of Research supported this project through pilot funding. CR ABBOTT BC, 1953, J PHYSIOL-LONDON, V120, P319 Bamman MM, 1997, J STRENGTH COND RES, V11, P68 Basmajian J, 1974, MUSCLES ALIVE THEIR Basmajian JV, 1985, MUSCLES ALIVE THEIR BIGLAND B, 1954, J PHYSIOL-LONDON, V125, P322 BIGLAND B, 1954, J PHYSIOL-LONDON, V123, P214 Blitzer A, 2009, OTOLARYNG HEAD NECK, V140, P782, DOI 10.1016/j.otohns.2009.01.026 Burden A, 2010, J ELECTROMYOGR KINES, V20, P1023, DOI 10.1016/j.jelekin.2010.07.004 De Luca C.J., 2002, SURFACE ELECTROMYOGR Donzelli J, 2004, ARCH OTOLARYNGOL, V130, P208, DOI 10.1001/archotol.130.2.208 Heman-Ackah YD, 2007, OTOLARYNG CLIN N AM, V40, P1003, DOI 10.1016/j.otc.2007.05.007 Hillel AD, 2001, LARYNGOSCOPE, V111, P1, DOI 10.1097/00005537-200104001-00001 HIRANO M, 1970, FOLIA PHONIATR, V22, P1 Huber JE, 2003, J SPEECH LANG HEAR R, V46, P1207, DOI 10.1044/1092-4388(2003/094) Koufman JA, 2001, OTOLARYNG HEAD NECK, V124, P603, DOI 10.1067/mhn.2001.115856 LINDESTAD PA, 1991, ACTA OTO-LARYNGOL, V111, P1146, DOI 10.3109/00016489109138464 LINDESTAD PA, 1994, ACTA OTO-LARYNGOL, V114, P91, DOI 10.3109/00016489409126023 LUDLOW CL, 1994, ANN OTO RHINOL LARYN, V103, P16 Rosner B., 2005, FUNDAMENTALS BIOSTAT Rubin AD, 2007, OTOLARYNG CLIN N AM, V40, P1109, DOI 10.1016/j.otc.2007.05.012 Sataloff R, 2006, LARYNGEAL ELECTROMYO Sataloff RT, 2004, J VOICE, V18, P261, DOI 10.1016/S0892-1997(03)00008-0 Sataloff RT, 2010, J VOICE, V24, P228, DOI 10.1016/j.jvoice.2008.08.005 Sittel C, 2001, ARCH OTOLARYNGOL, V127, P155 Smith LJ, 2012, LARYNGOSCOPE, V122, P854, DOI 10.1002/lary.21884 Statham MM, 2010, LARYNGOSCOPE, V120, P2036, DOI 10.1002/lary.21046 University of Iowa Health Care, IOW HEAD NECK PROT L Woo P, 1998, ARCH OTOLARYNGOL, V124, P472 YANG JF, 1983, ARCH PHYS MED REHAB, V64, P417 NR 29 TC 0 Z9 0 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD APR PY 2014 VL 123 IS 4 BP 271 EP 278 DI 10.1177/0003489414525022 PG 8 WC Otorhinolaryngology SC Otorhinolaryngology GA AG5YD UT WOS:000335494100009 PM 24671483 ER PT J AU Loftus, PA Ow, TJ Siegel, B Tassler, AB Smith, RV Cohen, HW Schiff, BA AF Loftus, Patricia A. Ow, Thomas J. Siegel, Bianca Tassler, Andrew B. Smith, Richard V. Cohen, Hillel W. Schiff, Bradley A. TI Risk Factors for Perioperative Airway Difficulty and Evaluation of Intubation Approaches Among Patients With Benign Goiter SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE goiter; nodular; airway obstruction; airway management; intubation; endotracheal intubation ID THYROID-SURGERY; CLINICAL-TRIAL; OBSTRUCTION; MANAGEMENT; GLIDESCOPE; PLACEMENT; DISEASE; TUBE; MYTH AB Objective: The objective was to determine patient and gland characteristics associated with difficult intubation in patients undergoing thyroidectomy for goiter and to assess different methods of intubation in these patients. Methods: This study was an IRB-approved, retrospective chart review of 112 consecutive patients undergoing hemithyroidectomy or total thyroidectomy for thyroid goiter from 2009-2012 at an academic tertiary care facility in Bronx, New York. Patient demographics, thyroid gland characteristics (gland weight and nodule size), presence of preoperative symptoms (dyspnea, dysphagia, and hoarseness), and radiographical findings (tracheal compression, tracheal deviation, and substernal extension of the thyroid gland) were recorded. Anesthesia records were reviewed for method of intubation, as well as success or failure of intubation attempts. Results: Nineteen patients (17.0%) were men and 93 (83.0%) were women. The age of the patients included in the study ranged from 14 to 86 years with a mean +/- SD age of 53.5 +/- 14.7 years. Difficult intubation was noted with 13 (11.6%) patients. Only patient age was significantly associated with difficult intubation. The mean age of patients with airway difficulty was 60.7 +/- 3.7 years compared to 52.1 +/- 1.5 years in those who did not experience airway difficulty (P = .04). No other reviewed risk factors were found to be significantly associated with difficult intubation. Fiberoptic intubation (FOI) was used in 38 patients and difficult intubation occurred in 18.4% (7/38). Direct laryngoscopy with transoral intubation (LTOI) was used in 58 patients, in whom 3.4% (2/58) experienced a difficult intubation. FOI was aborted 6 times and LTOI was subsequently successful in each of these cases. Conclusions: Our results suggest that benign nodular goiter disease does not pose significant challenges to intubation in our patient cohort. The technique of intubation deviated from the initial plan several times in the FOI group, whereas LTOI was ultimately successful in every case. Our data suggest that the role of fiberoptic intubation for patients with large goiters should be further refined. C1 [Loftus, Patricia A.; Ow, Thomas J.; Siegel, Bianca; Tassler, Andrew B.; Smith, Richard V.; Cohen, Hillel W.; Schiff, Bradley A.] Albert Einstein Coll Med, Montefiore Med Ctr, Dept Otorhinolaryngol Head & Neck Surg, Bronx, NY 10467 USA. RP Schiff, BA (reprint author), Albert Einstein Coll Med, Montefiore Med Ctr, Dept Otorhinolaryngol, 3400 Bainbridge Ave,Med Arts Pavilion,3rd Fl, Bronx, NY 10467 USA. EM bschiff@montefiore.org CR Agro F, 2001, CAN J ANAESTH, V48, P592 Amathieu R, 2006, ANESTH ANALG, V103, P965, DOI 10.1213/01.ane.0000237305.02465.ee AYABE H, 1992, SURG TODAY, V22, P88 Bennett AMD, 2004, J LARYNGOL OTOL, V118, P778 Bensghir M, 2013, CAN J ANESTH, V60, P377, DOI 10.1007/s12630-012-9870-x Berkow L, 2011, J CLIN ANESTH, V23, P81, DOI 10.1016/j.jclinane.2009.12.013 Bouaggad A, 2004, ANESTH ANALG, V99, P603, DOI 10.1213/01.ANE.0000122634.69923.67 Gerstein NS, 2010, CAN J ANAESTH, V57, P588, DOI 10.1007/s12630-010-9272-x Gervasi R, 2012, BMC SURG, V12, DOI 10.1186/1471-2482-12-S1-S16 Gharib Hossein, 2006, Endocr Pract, V12, P63 HASSARD AD, 1982, J OTOLARYNGOL, V11, P77 Hong BW, 2012, WORLD J SURG, V36, P2584, DOI 10.1007/s00268-012-1720-z HUNG OR, 1995, ANESTHESIOLOGY, V83, P509, DOI 10.1097/00000542-199509000-00009 Kanotra SP, 2012, J LARYNGOL OTOL, V126, P1271, DOI 10.1017/S0022215112002460 Khan MNA, 2010, J PAK MED ASSOC, V60, P736 MACK E, 1995, SURG CLIN N AM, V75, P377 Mallat J, 2010, ANN FR ANESTH, V29, P436, DOI 10.1016/j.annfar.2010.03.023 MCHENRY CR, 1994, AM SURGEON, V60, P586 Moon Hyoung-Yong, 2013, Korean J Anesthesiol, V64, P308, DOI 10.4097/kjae.2013.64.4.308 SHAHA AR, 1990, OTOLARYNG CLIN N AM, V23, P391 Thusoo TK, 2000, WORLD J SURG, V24, P1570 Voyagis GS, 1997, ANESTH ANALG, V84, P611, DOI 10.1097/00000539-199703000-00027 NR 22 TC 1 Z9 1 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD APR PY 2014 VL 123 IS 4 BP 279 EP 285 DI 10.1177/0003489414524171 PG 7 WC Otorhinolaryngology SC Otorhinolaryngology GA AG5YD UT WOS:000335494100010 PM 24595624 ER PT J AU Lim, HW Lee, JW Chung, JW AF Lim, Hyun Woo Lee, Ji Won Chung, Jong Woo TI Vulnerability to Acoustic Trauma in the Normal Hearing Ear With Contralateral Hearing Loss SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE unilateral hearing loss; noise-induced hearing loss; temporary threshold shift; feedback; interaural coupling ID GUINEA-PIG COCHLEA; LATERAL OLIVOCOCHLEAR EFFERENTS; PRODUCT OTOACOUSTIC EMISSION; LOUD SOUND; INJURY; REFLEX; PROTECTION; RESPONSES; DOPAMINE; RELEASE AB Objectives: We undertook an animal study to investigate the functional and histological changes that occur in the normal hearing ear of following acoustic trauma. Methods: As an animal model of unilateral hearing loss, the right ears of CBA mice were deafened by cochlear destruction at 6 weeks of age (SSD group). The control groups included mice that underwent a sham surgery, and mice that were exposed to noise binaurally and monaurally (by plugging the right ear completely). At 10 weeks of age, all mice were exposed to acoustic trauma (110 dB sound pressure level for 1 hour) that induced a transient threshold shift (TTS). Changes in the hearing thresholds of the left ear were assessed over the next 4 weeks by measuring the auditory brainstem responses (ABRs) and distortion product otoacoustic emissions (DPOAEs). Results: Following the noise exposure, the SSD group showed a permanent threshold shift (PTS) of about 10 dB, whereas the other groups showed full recovery from the TTS. The threshold of the DPOAEs of the left ears were increased after noise exposure but returned to normal in all groups, with no significant differences among the groups. Histological evaluation showed no apparent cellular loss or apoptosis in the left ears of all groups, including the SSD group. Conclusions: These results suggest that normal hearing ears are more vulnerable to acoustic trauma following contralateral unilateral cochlear ablation. This increased vulnerability may be due to damaged neural structures. C1 [Lim, Hyun Woo] Univ Ulsan, Gangneung Asan Hosp, Coll Med, Dept Otolaryngol, Kangnung, South Korea. [Lee, Ji Won; Chung, Jong Woo] Univ Ulsan, Coll Med, Asan Med Ctr, Dept Otolaryngol, Seoul 138736, South Korea. RP Chung, JW (reprint author), Univ Ulsan, Coll Med, Asan Med Ctr, Dept Otolaryngol, 388-1 Pungnap,2 Dong, Seoul 138736, South Korea. EM jwchung@amc.seoul.kr FU National Research Foundation of Korea (NRF) - Korea government (MEST) [2011-0026811] FX The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MEST) (2011-0026811). CR Abdala C, 2009, J ACOUST SOC AM, V125, P1584, DOI 10.1121/1.3068442 Bledsoe SC, 2009, J NEUROPHYSIOL, V102, P886, DOI 10.1152/jn.91003.2008 Guinan JJ, 2006, EAR HEARING, V27, P589, DOI 10.1097/01.aud.0000240507.83072.e7 Guinan JJ, 2003, JARO-J ASSOC RES OTO, V4, P521, DOI 10.1007/s10162-002-3037-3 Halmos G, 2005, NEUROSCIENCE, V132, P801, DOI 10.1016/j.neuroscience.2005.01.023 Irving S, 2011, J NEUROSCI, V31, P2493, DOI 10.1523/JNEUROSCI.2679-10.2011 Kang WS, 2012, NEUROREPORT, V23, P201, DOI 10.1097/WNR.0b013e328350235f Khimich D, 2005, NATURE, V434, P889, DOI 10.1038/nature03418 Kujawa SG, 1997, J NEUROPHYSIOL, V78, P3095 Kujawa SG, 2009, J NEUROSCI, V29, P14077, DOI 10.1523/JNEUROSCI.2845-09.2009 Larsen E, 2010, HEARING RES, V260, P70, DOI 10.1016/j.heares.2009.11.011 Lendvai B, 2011, NEUROCHEM INT, V59, P150, DOI 10.1016/j.neuint.2011.05.015 Le Prell CG, 2004, J ACOUST SOC AM, V116, P1044, DOI 10.1121/1.1772395 Le Prell CG, 2007, J NEUROPHYSIOL, V97, P963 Liberman MC, 1996, J ACOUST SOC AM, V99, P3572, DOI 10.1121/1.414956 Maison SF, 2002, J NEUROSCI, V22, P10838 PUEL JL, 1995, CR ACAD SCI III-VIE, V318, P67 RAJAN R, 1989, HEARING RES, V39, P299, DOI 10.1016/0378-5955(89)90049-X Rajan R, 2001, J NEUROPHYSIOL, V85, P1257 ROBERTSON D, 1994, BRAIN RES, V646, P37, DOI 10.1016/0006-8993(94)90055-8 Sumner CJ, 2005, J NEUROPHYSIOL, V94, P4234, DOI 10.1152/jn.00401.2005 Wang Y, 2012, JARO-J ASSOC RES OTO, V13, P505, DOI 10.1007/s10162-012-0329-0 Wang Y, 2002, JARO, V3, P248, DOI 10.1007/s101620020028 NR 23 TC 0 Z9 0 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD APR PY 2014 VL 123 IS 4 BP 286 EP 292 DI 10.1177/0003489414525339 PG 7 WC Otorhinolaryngology SC Otorhinolaryngology GA AG5YD UT WOS:000335494100011 PM 24671484 ER PT J AU Vorasubin, N Vira, D Jamal, N Chhetri, DK AF Vorasubin, Nopawan Vira, Darshni Jamal, Nausheen Chhetri, Dinesh K. TI Airway Management and Endoscopic Treatment of Subglottic and Tracheal Stenosis: The Laryngeal Mask Airway Technique SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE subglottic stenosis; tracheal stenosis; airway management; laryngeal mask airway; CO2 laser; balloon dilation ID WEGENERS-GRANULOMATOSIS; LASER-SURGERY; MITOMYCIN-C; LARYNGOTRACHEAL STENOSIS; CO2-LASER; DILATION AB Objectives: The objective is to present clinical outcomes of subglottic and tracheal stenosis treated by flexible bronchoscopic delivery of carbon dioxide (CO2) laser via laryngeal mask airway (LMA). Methods: All consecutive, nontracheotomy dependent cases of subglottic and tracheal stenosis treated endoscopically over a 4-year period were retrospectively reviewed. The surgical approach consisted of radial incisions using a flexible fiber-based CO2 laser, balloon dilation, and topical application of mitomycin C. Ventilation during the procedure occurred through the LMA, and the CO2 laser fiber was delivered through the working channel of a flexible bronchoscope passed through the LMA. Number of dilations, period between dilations, and operative times were reviewed. Results: Eleven patients who underwent airway intervention during the study period were identified. Average follow-up was 28 months. Etiologies of airway stenosis included intubation injury (6), idiopathic (4), or autoimmune disease (1), requiring an average of 1.3, 1.5, and 3 dilations, respectively. Average operative time was 67 minutes. Autoimmune etiology correlated with more frequent dilations. Conclusion: LMA is an effective way to manage ventilation while simultaneously allowing unencumbered flexible bronchoscopic access for laser surgery, balloon dilation, and mitomycin C application for airway stenosis. Long-term success in treating stenosis is achievable using this technique. C1 [Vorasubin, Nopawan; Vira, Darshni; Chhetri, Dinesh K.] Univ Calif Los Angeles, David Geffen Sch Med, Dept Head & Neck Surg, Los Angeles, CA 90095 USA. [Jamal, Nausheen] Temple Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, Philadelphia, PA 19122 USA. RP Vorasubin, N (reprint author), Univ Calif Los Angeles, David Geffen Sch Med, Dept Head & Neck Surg, 10833 Conte Ave,CHS 62-132, Los Angeles, CA 90095 USA. EM nvorasubin@mednet.ucla.edu FU National Institutes of Health [RO1 DC011300] FX The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This study was supported in part by grant RO1 DC011300 from the National Institutes of Health. CR Ahmed F, 2010, EUR ARCH OTO-RHINO-L, V267, P1779, DOI 10.1007/s00405-010-1312-1 Alaani A, 2004, J LARYNGOL OTOL, V118, P786 BRIMACOMBE J, 1994, ANAESTH INTENS CARE, V22, P694 Chhetri DK, 2011, OP TECHS OTOLARYNGOL, V22, P131 Couraud L, 1988, Eur J Cardiothorac Surg, V2, P410, DOI 10.1016/1010-7940(88)90043-7 GRILLO HC, 1995, J THORAC CARDIOV SUR, V109, P486, DOI 10.1016/S0022-5223(95)70279-2 Hoffman GS, 2003, J RHEUMATOL, V30, P1017 Houlton JJ, 2011, LARYNGOSCOPE, V121, P1910, DOI 10.1002/lary.21915 Keller C, 1999, BRIT J ANAESTH, V82, P291 KOUFMAN JA, 1987, ARCH OTOLARYNGOL, V113, P314 KOUFMAN JA, 1981, OTOLARYNG HEAD NECK, V89, P215 LEBOVICS RS, 1992, LARYNGOSCOPE, V102, P1341, DOI 10.1288/00005537-199212000-00005 MYER CM, 1994, ANN OTO RHINOL LARYN, V103, P319 Nouraei SAR, 2006, LARYNGOSCOPE, V116, P12, DOI 10.1097/01.mlg.0000186657.62474.88 Plouin Gaudon I, 2005, ANN OTO RHINOL LARYN, V114, P115 Rahbar R, 2001, ANN OTO RHINOL LARYN, V110, P1 Remz M, 2013, ANESTH ANALG S1, V117, P1 Roediger FC, 2008, LARYNGOSCOPE, V118, P1542, DOI 10.1097/MLG.0b013e318179247a SHAPSHAY SM, 1987, ANN OTO RHINOL LARYN, V96, P661 Shvero J, 2007, YONSEI MED J, V48, P748, DOI 10.3349/ymj.2007.48.5.748 Simpson CB, 2006, LARYNGOSCOPE, V116, P1923, DOI 10.1097/01.mlg.0000235934.27964.88 SIMPSON GT, 1982, ANN OTO RHINOL LARYN, V91, P384 Smith ME, 2009, LARYNGOSCOPE, V119, P272, DOI 10.1002/lary.20056 STRONG MS, 1972, ANN OTO RHINOL LARYN, V81, P791 Valdez TA, 2002, ANN OTO RHINOL LARYN, V111, P690 NR 25 TC 1 Z9 2 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD APR PY 2014 VL 123 IS 4 BP 293 EP 298 DI 10.1177/0003489414525340 PG 6 WC Otorhinolaryngology SC Otorhinolaryngology GA AG5YD UT WOS:000335494100012 PM 24671485 ER PT J AU Timmermans, AJ Lansaat, L Theunissen, EAR Hamming-Vrieze, O Hilgers, FJM van den Brekel, MWM AF Timmermans, Adriana J. Lansaat, Liset Theunissen, Eleonoor A. R. Hamming-Vrieze, Olga Hilgers, Frans J. M. van den Brekel, Michiel W. M. TI Predictive Factors for Pharyngocutaneous Fistulization After Total Laryngectomy SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE chemoradiotherapy; pharyngocutaneous fistula; predictive factor; radiotherapy; total laryngectomy ID SALVAGE TOTAL LARYNGECTOMY; PECTORALIS MYOFASCIAL FLAP; MULTIVARIATE-ANALYSIS; PREDISPOSING FACTORS; WOUND COMPLICATIONS; RISK-FACTORS; FISTULA; THERAPY; EXPERIENCE; SURGERY AB Objectives: Postoperative complications, especially pharyngocutaneous fistulization (PCF), are more frequent after total laryngectomy (TL) performed for salvage after (chemo) radiotherapy than after primary TL. The aim of this study was to identify the incidence of PCF, predictive factors for PCF, and the relationship of PCF to survival. Methods: We performed a retrospective chart review of 217 consecutive patients treated with TL between 2000 and 2010. Univariate and multivariable analysis with logistic regression was used to identify factors associated with PCF. We used a Kaplan-Meier survival analysis. Results: The overall incidence of PCF was 26.3% (57 of 217 cases). The incidence of PCF after primary TL was 17.1% (12 of 70), that after salvage TL was 25.5% (25 of 98), that after TLE for a second primary was 37.5% (9 of 24), and that after TL for a dysfunctional larynx was 44.0% (11 of 25). The predictive factors for PCF were hypopharynx cancer (odds ratio [OR], 3.67; 95% confidence interval [CI], 1.74 to 7.71; P = .001), an albumin level of less than 40 g/L (OR, 2.20; 95% CI, 1.12 to 4.33; P = .022), previous chemoradiotherapy (OR, 3.38; 95% CI, 1.34 to 8.52; P = .010), more-extended pharyngeal resection (P = .001), and pharynx reconstruction (P = .002). The median duration of survival was 30 months (95% CI, 17.5 to 42.5); the 2-year overall survival rate was 54%. The median duration of survival of patients with PCF was 23 months (95% CI, 9.4 to 36.6), and that of those without PCF was 31 months (95% CI, 15.0 to 47.0; P = .421). The 2-year overall survival rate was 48% in patients with PCF and 57% in those without PCF (P = .290). Conclusions: Incidence of PCF after TL is significantly higher in patients with hypopharynx cancer, previous chemoradiotherapy, a low albumin level, more-extended pharyngeal resection, or pharynx reconstruction. The occurrence of PCF does not influence the rate of survival. C1 [Timmermans, Adriana J.; Lansaat, Liset; Theunissen, Eleonoor A. R.; Hilgers, Frans J. M.; van den Brekel, Michiel W. M.] Univ Amsterdam, Dept Head & Neck Oncol & Surg, NL-1066 CX Amsterdam, Netherlands. [Hamming-Vrieze, Olga] Univ Amsterdam, Dept Radiotherapy, NL-1066 CX Amsterdam, Netherlands. [Hilgers, Frans J. M.; van den Brekel, Michiel W. M.] Univ Amsterdam, Canc Inst, NL-1066 CX Amsterdam, Netherlands. [Hilgers, Frans J. M.; van den Brekel, Michiel W. M.] Univ Amsterdam, Inst Phonet Sci, NL-1066 CX Amsterdam, Netherlands. RP Timmermans, AJ (reprint author), Univ Amsterdam, Dept Head & Neck Oncol & Surg, Plesmanlaan 121, NL-1066 CX Amsterdam, Netherlands. EM j.timmermans@nki.nl FU Department of Head and Neck Oncology and Surgery of the Netherlands Cancer Institute from Atos Medical, Sweden FX The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: Part of the study was supported through an unrestricted research grant that the Department of Head and Neck Oncology and Surgery of the Netherlands Cancer Institute receives from Atos Medical, Sweden. CR Boscolo-Rizzo P, 2008, EUR ARCH OTO-RHINO-L, V265, P929, DOI 10.1007/s00405-007-0562-z de Bruin-Visser JC, 2012, EUR ARCH OTO-RHINO-L, V269, P659, DOI 10.1007/s00405-011-1673-0 Erdag MA, 2013, EUR ARCH OTO-RHINO-L, V270, P173, DOI 10.1007/s00405-012-2111-7 Fung K, 2007, HEAD NECK-J SCI SPEC, V29, P425, DOI 10.1002/hed.20492 Galli J, 2005, OTOLARYNG HEAD NECK, V133, P689, DOI 10.1016/j.otohns.2005.07.025 Ganly I, 2005, CANCER, V103, P2073, DOI 10.1002/cncr.20974 Genden EM, 2004, ACTA OTO-LARYNGOL, V124, P117, DOI 10.1080/00016480310015191 Gil Z, 2009, ARCH OTOLARYNGOL, V135, P1019, DOI 10.1001/archoto.2009.126 Klozar J, 2012, EUR ARCH OTO-RHINO-L, V269, P289, DOI 10.1007/s00405-011-1598-7 Lorenz KJ, 2011, EUR ARCH OTO-RHINO-L, V268, P695, DOI 10.1007/s00405-010-1446-1 Makitie AA, 2006, EUR ARCH OTO-RHINO-L, V263, P1127, DOI 10.1007/s00405-006-0152-5 NATVIG K, 1993, J LARYNGOL OTOL, V107, P1136 Parikh SR, 1998, J OTOLARYNGOL, V27, P136 Patel UA, 2009, OTOLARYNG HEAD NECK, V141, P190, DOI 10.1016/j.otohns.2009.03.024 Patel UA, 2013, JAMA OTOLARYNGOL, V139, P1156, DOI 10.1001/jamaoto.2013.2761 Paydarfar JA, 2006, ARCH OTOLARYNGOL, V132, P67, DOI 10.1001/archotol.132.1.67 Prasad KC, 2006, ANN OTO RHINOL LARYN, V115, P433 Qureshi S S, 2005, J Cancer Res Ther, V1, P51 de Zinis LOR, 1999, HEAD NECK-J SCI SPEC, V21, P131, DOI 10.1002/(SICI)1097-0347(199903)21:2<131::AID-HED6>3.0.CO;2-F Righini C, 2005, EUR ARCH OTO-RHINO-L, V262, P357, DOI 10.1007/s00405-004-0827-8 Russell NS, 2009, RADIOTHER ONCOL, V92, P477, DOI 10.1016/j.radonc.2009.05.021 Schwartz SR, 2004, OTOLARYNG HEAD NECK, V131, P61, DOI 10.1016/j.otohns.2003.08.028 Seven H, 2003, LARYNGOSCOPE, V113, P1076, DOI 10.1097/00005537-200306000-00030 Sherman EJ, 2012, LARYNGOSCOPE, V122, P1043, DOI 10.1002/lary.23220 Sousa AA, 2012, BRAZ J OTORHINOLAR, V78, P103, DOI 10.1590/S1808-86942012000400019 Theunissen EAR, 2012, ARCH OTOLARYNGOL, V138, P548, DOI 10.1001/archoto.2012.862 Timmermans AJ, 2013, EUR ARCH OTORHINOLAR Tsou YA, 2010, HEAD NECK-J SCI SPEC, V32, P1494, DOI 10.1002/hed.21352 Virtaniemi JA, 2001, HEAD NECK-J SCI SPEC, V23, P29, DOI 10.1002/1097-0347(200101)23:1<29::AID-HED5>3.0.CO;2-P Wakisaka N, 2008, AURIS NASUS LARYNX, V35, P203, DOI 10.1016/j.anl.2007.06.002 Weber RS, 2003, ARCH OTOLARYNGOL, V129, P44 White HN, 2012, LARYNGOSCOPE, V122, P1796, DOI 10.1002/lary.23443 NR 32 TC 1 Z9 1 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD MAR PY 2014 VL 123 IS 3 BP 153 EP 161 DI 10.1177/0003489414522972 PG 9 WC Otorhinolaryngology SC Otorhinolaryngology GA AC3QQ UT WOS:000332436700001 PM 24633941 ER PT J AU Magliulo, G Gagliardi, S Appiani, MC Iannella, G Re, M AF Magliulo, Giuseppe Gagliardi, Silvia Appiani, Mario Ciniglio Iannella, Giannicola Re, Massimo TI Vestibular Neurolabyrinthitis: A Follow-Up Study With Cervical and Ocular Vestibular Evoked Myogenic Potentials and the Video Head Impulse Test SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE cervical vestibular evoked myogenic potential; ocular vestibular evoked myogenic potential; vestibular neurolabyrinthitis; video head impulse test ID CANAL FUNCTION; NEURITIS; NERVE; RECOVERY; SUPERIOR; VEMP; REHABILITATION; PRESERVATION; VERTIGO AB Objectives: The aim of this study was to evaluate prospectively, in a group of patients affected by vestibular neurolabyrinthitis (VN), a diagnostic protocol including cervical vestibular evoked myogenic potentials (C-VEMPs), ocular vestibular evoked myogenic potentials (O-VEMPs), and the video head impulse test (vHIT). Methods: The diagnosis of VN was based on the patient's clinical history, an absence of associated auditory or neurologic symptoms, and a neuro-dtological examination with an evaluation of lateral semicircular canal function by use of the Fitzgerald-Hallpike caloric vestibular test and the ice test. Results: In our series, 55% of the cases were superior and inferior VN, 40% were superior VN, and 5% were inferior VN. These cases, however, comprised different degrees of vestibular involvement, as the individual vestibular end organs have different prognoses. Four patients had only deficits of the horizontal and superior semicircular canals or their ampullary nerves. Conclusions: The implementation of C-VEMPs, O-VEMPs, and the vHIT in a vestibular diagnostic protocol has made it possible to observe patients with ampullary VN in a way that has not been feasible with other types of vestibular examinations. The age of the patient seems to have some impact on recovery from VN. When recovery occurs in the utricular and saccular nerves first and in the ampullary nerves subsequently, it may be reasonable to expect a more favorable outcome. C1 [Magliulo, Giuseppe; Gagliardi, Silvia; Appiani, Mario Ciniglio; Iannella, Giannicola] Univ Roma La Sapienza, Dept Sensory Organs, I-00185 Rome, Italy. [Re, Massimo] Marche Polytech Univ, Dept Clin Sci, Ancona, Italy. RP Magliulo, G (reprint author), Via Gregorio VII 80, I-00165 Rome, Italy. EM giuseppemagliuloorl@yahoo.com CR Aw ST, 2001, NEUROLOGY, V57, P768 Baloh RW, 2003, NEW ENGL J MED, V348, P1027, DOI 10.1056/NEJMcp021154 Bergenius J, 1999, ACTA OTO-LARYNGOL, V119, P895 Curthoys IS, 2011, CLIN NEUROPHYSIOL, V122, P611, DOI 10.1016/j.clinph.2010.07.018 Curthoys IS, 2010, CLIN NEUROPHYSIOL, V121, P132, DOI 10.1016/j.clinph.2009.09.027 Eleftheriadou A, 2012, EUR ARCH OTO-RHINO-L, V269, P2309, DOI 10.1007/s00405-012-2019-2 Faralli M, 2006, OTOL NEUROTOL, V27, P1115, DOI 10.1097/01.mao.0000231501.46534.30 Fetter M, 1996, BRAIN, V119, P755, DOI 10.1093/brain/119.3.755 Goebel JA, 2001, OTOL NEUROTOL, V22, P512, DOI 10.1097/00129492-200107000-00018 Govender S, 2011, CLIN NEUROPHYSIOL, V122, P1246, DOI 10.1016/j.clinph.2010.12.040 Halmagyi GM, 2002, ANN NY ACAD SCI, V956, P306 Han BI, 2011, J CLIN NEUROL, V7, P184, DOI 10.3988/jcn.2011.7.4.184 Hong SM, 2008, ACTA OTO-LARYNGOL, V128, P861, DOI 10.1080/00016480701784981 HORAK FB, 1992, OTOLARYNG HEAD NECK, V106, P175 Kim HA, 2008, NEUROLOGY, V70, P449, DOI 10.1212/01.wnl.0000297554.21221.a0 Kim JS, 2012, J NEUROL, V259, P1553, DOI 10.1007/s00415-011-6375-4 Leveque M, 2010, AURIS NASUS LARYNX, V37, P308, DOI 10.1016/j.anl.2009.06.006 MacDougall HG, 2009, NEUROLOGY, V73, P1134, DOI 10.1212/WNL.0b013e3181bacf85 Magliulo G, 2007, ARCH OTOLARYNGOL, V133, P720, DOI 10.1001/archotol.133.7.720 Magliulo G, 2012, ANN OTO RHINOL LARYN, V121, P640 Magliulo G, 2003, OTOL NEUROTOL, V24, P308, DOI 10.1097/00129492-200303000-00029 Magliulo G, 2004, ANN OTO RHINOL LARYN, V113, P1000 Magliulo G, 2004, LARYNGOSCOPE, V114, P338, DOI 10.1097/00005537-200402000-00030 Murofushi T, 2006, ACTA OTO-LARYNGOL, V126, P364, DOI 10.1080/00016480500417189 Murofushi T, 2003, NEUROLOGY, V61, P417 Murofushi T, 1996, ARCH OTOLARYNGOL, V122, P845 Newman-Toker DE, 2008, NEUROLOGY, V70, P2378, DOI 10.1212/01.wnl.0000314685.01433.0d Ochi K, 2003, J LARYNGOL OTOL, V117, P104 OKINAKA Y, 1993, ACTA OTO-LARYNGOL, P18 Reiss M, 2012, EUR ARCH OTO-RHINO-L, V269, P1091, DOI 10.1007/s00405-011-1763-z Schmid-Priscoveanu A, 2001, JARO, V2, P72, DOI 10.1007/s101620010060 Shin BS, 2012, CLIN NEUROPHYSIOL, V123, P369, DOI 10.1016/j.clinph.2011.05.029 Strupp M, 1998, J VESTIBUL RES-EQUIL, V8, P427 Ulmer E, 2005, Ann Otolaryngol Chir Cervicofac, V122, P84, DOI 10.1016/S0003-438X(05)82329-1 Ulmer E, 2011, EUR ANN OTORHINOLARY, V128, P278, DOI 10.1016/j.anorl.2011.05.005 Welgampola MS, 2010, OTOLARYNG HEAD NECK, V143, P281, DOI 10.1016/j.otohns.2010.05.024 NR 36 TC 2 Z9 2 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD MAR PY 2014 VL 123 IS 3 BP 162 EP 173 DI 10.1177/0003489414522974 PG 12 WC Otorhinolaryngology SC Otorhinolaryngology GA AC3QQ UT WOS:000332436700002 PM 24633942 ER PT J AU Jones, CA Hammer, MJ Hoffman, MR McCulloch, TM AF Jones, Corinne A. Hammer, Michael J. Hoffman, Matthew R. McCulloch, Timothy M. TI Quantifying Contributions of the Cricopharyngeus to Upper Esophageal Sphincter Pressure Changes by Means of Intramuscular Electromyography and High-Resolution Manometry SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE cricopharyngeus; deglutition; electromyography; high-resolution manometry; upper esophageal sphincter ID DE-GLUTITION; CONTRACTILE ACTIVITIES; PHONATION; MUSCLE; VOLUME; HEAD; DEGLUTITION; MECHANISMS; REFLEX; LARYNX AB Objectives: We sought to determine whether the association between cricopharyngeus muscle activity and upper esophageal sphincter pressure may change in a task-dependent fashion. We hypothesized that more automated tasks related to swallow or airway protection would yield a stronger association than would more volitional tasks related to tidal breathing or voice production. Methods: Six healthy adult subjects underwent simultaneous intramuscular electromyography of the cricopharyngeus muscle and high-resolution manometry of the upper esophageal sphincter. Correlation coefficients were calculated to characterize the association between the time-linked series. Results: Cricopharyngeus muscle activity was most strongly associated with upper esophageal sphincter pressure during swallow and effortful exhalation tasks (r = 0.77 and 0.79, respectively; P <.01). The association was also less variable during swallow and effortful exhalation. Conclusions: These findings suggest a greater coupling for the more automatic tasks, and may suggest less coupling and more flexibility for the more volitional, voice-related tasks. These findings support the important role of central patterning for respiratory-and swallow-related tasks. C1 [Jones, Corinne A.; Hammer, Michael J.; Hoffman, Matthew R.; McCulloch, Timothy M.] Univ Wisconsin, Sch Med & Publ Hlth, Dept Surg, Div Otolaryngol Head & Neck Surg, Madison, WI USA. RP McCulloch, TM (reprint author), Clin Sci Ctr H4, Box 7375,600 Highland Ave, Madison, WI 53792 USA. EM mccull@surgery.wisc.edu FU NIH from the National Institute on Deafness and Other Communication Disorders [R21 DC011130A]; NIH [DC010900, RR025012, RR023268] FX The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: Supported by NIH grant R21 DC011130A from the National Institute on Deafness and Other Communication Disorders. Dr Hammer also receives funding from NIH grants DC010900, RR025012, and RR023268. CR ASOH R, 1978, GASTROENTEROLOGY, V74, P514 Babaei A, 2012, GASTROENTEROLOGY, V142, P734, DOI 10.1053/j.gastro.2012.01.006 COOK IJ, 1989, AM J PHYSIOL, V257, pG748 Cook I J, 1989, Dysphagia, V4, P8, DOI 10.1007/BF02407397 DOTY RW, 1956, J NEUROPHYSIOL, V19, P44 ERTEKIN C, 1995, MUSCLE NERVE, V18, P1177, DOI 10.1002/mus.880181014 Ertekin C, 2002, MUSCLE NERVE, V26, P729, DOI 10.1002/mus.10267 Fox MR, 2008, GUT, V57, DOI 10.1136/gut.2007.127993 Ghosh SK, 2006, AM J PHYSIOL-GASTR L, V291, pG525, DOI 10.1152/ajpgi.00081.2006 Hammer MJ, 2010, EXP BRAIN RES, V201, P401, DOI 10.1007/s00221-009-2048-2 Hatsopoulos N, 2004, J NEUROPHYSIOL, V92, P1165, DOI 10.1152/jn.01245.2003 Hoffman MR, 2010, LARYNGOSCOPE, V120, P2367, DOI 10.1002/lary.21150 ISBERG A, 1985, ACTA RADIOL DIAGN, V26, P563 ISBERG A, 1985, ACTA RADIOL DIAGN, V26, P381 Iwarsson J, 1998, J VOICE, V12, P159, DOI 10.1016/S0892-1997(98)80035-0 JACOB P, 1990, AM J PHYSIOL, V259, pG245 JACOB P, 1989, GASTROENTEROLOGY, V97, P1469 Jean A, 2001, PHYSIOL REV, V81, P929 KAHRILAS PJ, 1988, GASTROENTEROLOGY, V95, P52 Kahrilas PJ, 1997, AM J MED, V103, p56S, DOI 10.1016/S0002-9343(97)00324-0 LANG IM, 1991, AM J PHYSIOL, V260, pG911 MARTIN F, 1983, LARYNG RHINOL OTOL V, V62, P223, DOI 10.1055/s-2007-1008418 McCulloch TM, 2011, HEAD NECK-J SCI SPEC, V33, pS46, DOI 10.1002/hed.21901 McCulloch TM, 2010, ANN OTO RHINOL LARYN, V119, P369 Medda B, 1990, GASTROENTEROLOGY, V99, p1219A MEDDA B, 1993, GASTROENTEROLOGY, V104, pA551 Medda BK, 1997, AM J PHYSIOL-GASTR L, V273, pG470 Mielens JD, 2012, J SPEECH LANG HEAR R, V55, P892, DOI 10.1044/1092-4388(2011/11-0088) Miller AJ, 1999, NEUROSCIENTIFIC PRIN NETSELL R, 1978, J SPEECH HEAR DISORD, V43, P326 Perera L, 2008, AM J PHYSIOL-GASTR L, V294, pG885, DOI 10.1152/ajpgi.00470.2007 Takasaki K, 2010, OTOLARYNG HEAD NECK, V142, P214, DOI 10.1016/j.otohns.2009.10.033 Tokashiki R, 2010, EUR ARCH OTO-RHINO-L, V267, P737, DOI 10.1007/s00405-009-1134-1 VANOVERBEEK JJM, 1985, LARYNGOSCOPE, V95, P582 WELCH RW, 1979, J CLIN INVEST, V63, P1036, DOI 10.1172/JCI109372 NR 35 TC 1 Z9 1 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD MAR PY 2014 VL 123 IS 3 BP 174 EP 182 DI 10.1177/0003489414522975 PG 9 WC Otorhinolaryngology SC Otorhinolaryngology GA AC3QQ UT WOS:000332436700003 PM 24633943 ER PT J AU Howard, BE Moore, EJ Hinni, ML AF Howard, Brittany E. Moore, Eric J. Hinni, Michael L. TI Lingual Thyroidectomy: The Mayo Clinic Experience With Transoral Laser Microsurgery and Transoral Robotic Surgery SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article; Proceedings Paper CT Annual Meeting of the American-Head-and-Neck-Society (AHNS) held during the Combined-Otolaryngology-Society Meetings (COSM) CY APR 10-11, 2013 CL Orlando, FL SP Amer Head & Neck Soc, Combined Otolaryngol Soc DE ectopic thyroid gland; lingual thyroid gland; recurrence; transoral laser microsurgery; transoral robotic surgery AB Objectives: We report the clinical findings, surgical management, and outcomes for lingual thyroidectomy. Methods: We performed a retrospective case review of lingual thyroidectomy performed at 3 tertiary-care academic referral centers between 1994 and 2012. Results: Nine patients underwent lingual thyroidectomy for symptoms including globus sensation (6 patients), dysphagia (5 patients), and airway obstruction (5 patients). Before surgery, 3 patients had attempted medical suppressive therapy. Lingual thyroidectomy was performed by transoral laser microsurgery in 4 patients, transoral robotic surgery in 3 patients, transoral surgery without microscopic assistance in 1 patient, and an open approach with a modified Sistrunk procedure in I patient. Total thyroidectomy was attained in 7 patients, and subtotal resection in 2. The follow-up averaged 8 months, and all patients reported significant improvement in their symptoms. One patient had a recurrence. Complications included postoperative bleeding and epiglottic perforation in 1 patient and airway obstruction secondary to angioedema in another patient. There was no significant difference in operative times between transoral laser microsurgery (91 +/- 16 minutes) and transoral robotic surgery (109 +/- 35 minutes). Transoral surgery without microscopic assistance and open resection had longer operative times (206 and 246 minutes, respectively). Conclusions: Surgical resection of lingual thyroid glands achieves significant improvement in patient symptoms, with low rates of recurrence. We favor a total lingual thyroidectomy approach with use of either a microscope or a robotic endoscope for optical assistance. C1 [Howard, Brittany E.; Hinni, Michael L.] Mayo Clin, Dept Otorhinolaryngol, Phoenix, AZ USA. [Moore, Eric J.] Mayo Clin, Dept Otorhinolaryngol, Rochester, MN USA. RP Howard, BE (reprint author), 5777 E Mayo Blvd, Phoenix, AZ 85054 USA. EM Howard.brittany@mayo.edu CR BAUGHMAN RA, 1972, ORAL SURG ORAL MED O, V34, P781, DOI 10.1016/0030-4220(72)90296-4 Dziegielewski PT, 2011, J OTOLARYNGOL-HEAD N, V40, P19, DOI 10.2310/7070.2010.100112 FISH J, 1963, ANN SURG, V157, P212, DOI 10.1097/00000658-196302000-00006 Iglesias P, 2008, J CLIN ENDOCR METAB, V93, P4198, DOI 10.1210/jc.2008-0909 Kang HC, 2004, THYROID, V14, P401, DOI 10.1089/105072504774193267 KAPLAN M, 1978, J PEDIATR-US, V92, P205, DOI 10.1016/S0022-3476(78)80005-5 MONROE JB, 1975, ARCH OTOLARYNGOL, V101, P574 Montgomery ML, 1935, W J SURG, V43, P661 Montgomery ML, 1936, W J SURG, V44, P56 Montgomery ML., 1936, W J SURG, V44, P122 NEINAS FW, 1973, ANN INTERN MED, V79, P205 Patel Zeal, 2009, J Radiol Case Rep, V3, P3, DOI 10.3941/jrcr.v3i2.70 SAUK JJ, 1970, J PATHOL, V102, P239, DOI 10.1002/path.1711020408 Wapshaw H, 1942, BRIT J SURG, V30, P160, DOI 10.1002/bjs.18003011810 NR 14 TC 2 Z9 2 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD MAR PY 2014 VL 123 IS 3 BP 183 EP 187 DI 10.1177/0003489414522976 PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA AC3QQ UT WOS:000332436700004 PM 24633944 ER PT J AU Best, SR Kobler, JB Friedman, AD Barbu, AM Zeitels, SM Burns, JA AF Best, Simon R. Kobler, James B. Friedman, Aaron D. Barbu, Anca M. Zeitels, Steven M. Burns, James A. TI Effect of Mandibular Tori on Glottic Exposure During Simulated Suspension Microlaryngoscopy SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE difficult airway; difficult intubation; direct laryngoscopy; glottis; laryngoscope; larynx; mandibular tori; suspension microlaryngoscopy; vocal fold ID DIFFICULT LARYNGEAL EXPOSURE; LARYNGOSCOPY; PREDICTION; AIRWAY AB Objectives: Mandibular tori have been identified as a contributing factor in difficult exposure during intubation. However, no investigation has measured the effect of mandibular tori on glottic exposure during suspension nnicrolaryngoscopy (SML). The objective of this study was to measure how the size and location of mandibular tori affect glottic exposure during simulated SML at different thyromental distances. Methods: Suspension nnicrolaryngoscopy was modeled on an anatomically accurate skull and larynx with thyrornental distances between 6 and 12 cm. Mandibular tori were simulated by protruding screws 5 to 15 mm from the lingual aspect of the mandible. The tori were positioned either 15 mm (anterior) or 25 mm (posterior) from the nnidline of the symphysis. The glottic exposure for the various-size tori in each location was measured by recording the displacement of the glottiscope tip relative to the most anterior exposure achievable without tori. The glottiscope angle relative to the horizontal plane was measured for each condition. Results: Mandibular tori of more than 10 mm had a significant impact on glottic exposure. Displacement of the glottiscope tip ranged from 2 to 9 mm for anteriorly placed tori and from 7 to 29 mm for posteriorly placed tori, with larger tori causing greater displacement. Increasing the thyromental distance increased the posterior glottiscope tip displacement regardless of torus size or location. The glottiscope angle increased with larger tori (12 degrees to 28 degrees), but this angle did not change with increasing thyromental distance. Conclusions: Larger size and more-posterior location of mandibular tori more significantly reduce glottic exposure during SML. The inner table of.the mandible is the most relevant anatomic constraint on glottic exposure, which varies with the presence or absence of mandibular tori independent of thyromental distance. C1 [Best, Simon R.; Kobler, James B.; Friedman, Aaron D.; Barbu, Anca M.; Zeitels, Steven M.; Burns, James A.] Harvard Univ, Sch Med, Dept Surg, Boston, MA 02115 USA. [Best, Simon R.; Kobler, James B.; Friedman, Aaron D.; Barbu, Anca M.; Zeitels, Steven M.; Burns, James A.] Massachusetts Gen Hosp, Ctr Laryngeal Surg & Voice Rehabil, Boston, MA 02114 USA. RP Burns, JA (reprint author), Massachusetts Gen Hosp, Ctr Laryngeal Surg & Voice Rehabil, One Bowdoin Sq,11th Floor, Boston, MA 02114 USA. EM burns.james@mgh.harvard.edu FU Eugene B. Casey Foundation; "V" Foundation; Voice Health Institute FX The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported in part by the Eugene B. Casey Foundation, the "V" Foundation, and the Voice Health Institute. Dr Zeitels has an equity interest in Endocraft LLC. CR American Society of Plastic Surgeons, 2011 PLAST SURG STAT ElGanzouri AR, 1996, ANESTH ANALG, V82, P1197, DOI 10.1097/00000539-199606000-00017 Hsiung MW, 2004, LARYNGOSCOPE, V114, P358, DOI 10.1097/00005537-200402000-00033 Huh J, 2009, ANESTH ANALG, V108, P544, DOI 10.1213/ane.0b013e31818fc347 KOLAS S, 1953, ORAL SURG ORAL MED O, V6, P1134, DOI 10.1016/0030-4220(53)90225-4 Larsson H, 2008, J VOICE, V22, P734, DOI 10.1016/j.jvoice.2007.01.010 Pinar E, 2009, EUR ARCH OTO-RHINO-L, V266, P699, DOI 10.1007/s00405-008-0853-z REICHART PA, 1988, COMMUNITY DENT ORAL, V16, P61, DOI 10.1111/j.1600-0528.1988.tb00557.x Roh JL, 2005, ANN OTO RHINOL LARYN, V114, P614 ROSE DK, 1994, CAN J ANAESTH, V41, P372 Takasugi Y, 2009, J ANESTH, V23, P278, DOI 10.1007/s00540-008-0717-0 WOODS GM, 1995, ANESTH ANALG, V81, P870, DOI 10.1097/00000539-199510000-00037 Yoshida H, 2011, J ANESTH, V25, P473, DOI 10.1007/s00540-011-1128-1 Zeitels SM, 1999, ANN OTO RHINOL LARYN, V108, P2 NR 14 TC 0 Z9 0 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD MAR PY 2014 VL 123 IS 3 BP 188 EP 194 DI 10.1177/0003489414522967 PG 7 WC Otorhinolaryngology SC Otorhinolaryngology GA AC3QQ UT WOS:000332436700005 PM 24633945 ER PT J AU Hoffman, HT Heaford, AC Dailey, SH Bock, JM Van Daele, DJ Ahlrichs-Hanson, JS Quebbemann, GJ Johnson, MN Boltz, JE Tiedt, SL AF Hoffman, Henry T. Heaford, Andrew C. Dailey, Seth H. Bock, Jonathan M. Van Daele, Douglas J. Ahlrichs-Hanson, Jan S. Quebbemann, Greg J. Johnson, Micaela N. Boltz, Justin E. Tiedt, Sean L. TI Arytenoid Repositioning Device SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article; Proceedings Paper CT Meeting of the American-Broncho-Esophagological-Association CY APR 10-11, 2013 CL Orlando, FL SP Amer Broncho Esophagol Assoc DE arytenoid; larynx; minimal-access surgical procedure; paralysis; vocal cord ID CADAVERIC LARYNGEAL CARTILAGE; MEDIALIZATION LARYNGOPLASTY; ADDUCTION ARYTENOPEXY; PULLOUT STRENGTH; INJECTION LARYNGOPLASTY; RESORBABLE SCREWS; GORE-TEX; THYROPLASTY; PARALYSIS; SURGERY AB Objectives: We report development of a device and technique to manage laryngeal paralysis through minimal-access arytenoid adduction (for unilateral paralysis) and arytenoid abduction (for bilateral paralysis). Methods: A human cadaver study coupled with directed engineering was used to develop instrumentation designed to secure the muscular process of the arytenoid into favorable adducted or abducted positions. Digital video, photography, and 3-dimensional computed tomographic (CT) imaging of cadaveric larynges were done to evaluate the surgical technique. Results: Testing of prototypes identified the ideal implant to be a 0.36-mm wire with a distal spring-wound coil placed through a trocar via a small drill hole in the anterior thyroid cartilage. An endoscopic view of transilluminated light through the pyriform sinus mucosa identified the tip location of the trocar adjacent to the muscular process of the arytenoid cartilage. Placement of the device through the trocar permitted rotation to engage the muscular process and/or adjacent soft tissue with the distal coil. Implant fixation to the thyroid cartilage positioned the vocal cord into either adduction or abduction. Three-dimensional CT imaging coupled with review of the video documentation established the feasibility of this technique. Conclusions: We confirm the feasibility of minimal-access arytenoid adduction and abduction through development of a new technique and device. C1 [Hoffman, Henry T.; Heaford, Andrew C.; Van Daele, Douglas J.; Ahlrichs-Hanson, Jan S.] Univ Iowa, Dept Otolaryngol, Iowa City, IA 52242 USA. [Quebbemann, Greg J.; Johnson, Micaela N.; Boltz, Justin E.; Tiedt, Sean L.] Univ Iowa, Dept Biomed Engn, Iowa City, IA 52242 USA. [Dailey, Seth H.] Univ Wisconsin, Sch Med & Publ Hlth, Madison, WI USA. [Bock, Jonathan M.] Med Coll Wisconsin, Milwaukee, WI 53226 USA. RP Hoffman, HT (reprint author), Univ Iowa, Dept Otolaryngol, 200 Hawkins Dr, Iowa City, IA 52242 USA. EM Henry-hoffman@uiowa.edu CR Chester MW, 2003, OTOLARYNG HEAD NECK, V129, P305, DOI 10.1016/S0194-5998(03)01390-1 Dailey SH, 2004, LARYNGOSCOPE, V114, P878, DOI 10.1097/00005537-200405000-00017 Franco RA, 2009, J VOICE, V23, P261, DOI 10.1016/j.jvoice.2007.09.009 Grant N, 2008, OTOLARYNG HEAD NECK, V138, P807, DOI 10.1016/j.otohns.2008.02.019 Hoffman HT, IOWA HEAD NECK PROTO Hoffman MR, 2010, LARYNGOSCOPE, V120, P769, DOI 10.1002/lary.20830 Jung A, 2005, J NEUROSURG-SPINE, V2, P123, DOI 10.3171/spi.2005.2.2.0123 Kimura M, 2008, ANN OTO RHINOL LARYN, V117, P430 Lewis AF, 2008, HEAD NECK-J SCI SPEC, V30, P1464, DOI 10.1002/hed.20890 Maragos NE, 2006, ANN OTO RHINOL LARYN, V115, P171 McCulloch TM, 2000, LARYNGOSCOPE, V110, P1306, DOI 10.1097/00005537-200008000-00015 McNamar J, 2008, LARYNGOSCOPE, V118, P552, DOI 10.1097/MLG.0b013e31815acaf9 Mortensen M, 2009, LARYNGOSCOPE, V119, P827, DOI 10.1002/lary.20171 Plant RL, 1998, AM J OTOLARYNG, V19, P154, DOI 10.1016/S0196-0709(98)90080-1 Umeno H, 2008, ANN OTO RHINOL LARYN, V117, P5 Windham BP, 2007, LARYNGOSCOPE, V117, P1964, DOI 10.1097/MLG.0b013e31813437c6 WOO P, 1990, ANN OTO RHINOL LARYN, V99, P772 Woodson G, 2007, ANN OTO RHINOL LARYN, V116, P483 Zeitels SM, 1998, ANN OTO RHINOL LARYN, V107, P2 NR 19 TC 0 Z9 0 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD MAR PY 2014 VL 123 IS 3 BP 195 EP 205 DI 10.1177/0003489414522968 PG 11 WC Otorhinolaryngology SC Otorhinolaryngology GA AC3QQ UT WOS:000332436700006 PM 24633946 ER PT J AU Ruhl, DS Cable, BB Rieth, KKS AF Ruhl, Douglas S. Cable, Benjamin B. Rieth, Katherine K. S. TI Emergent Treatment of Button Batteries in the Esophagus: Evolution of Management and Need for Close Second-Look Esophagoscopy SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article; Proceedings Paper CT Meeting of the American-Broncho-Esophagological-Association CY APR 10-11, 2013 CL Orlando, FL SP Amer Broncho Esophagol Assoc DE button battery; esophageal injury; esophagoscopy ID CAUSTIC INGESTION; CHILDREN; PROTOCOL; BURN; DOGS AB Objectives: The evolving epidemiology of pediatric button battery ingestion is alarming. Currently, assessment of the degree of damage relies heavily on the initial esophagoscopy in a manner similar to the management of caustic ingestion. We have noted that use of this classic approach may delay the return to normal oral intake. Using several cases treated at our institution, we illustrate the value of "close second-look esophagoscopy" (CSLE) in expediting a return to normal oral intake after button battery ingestion. Methods: We present a retrospective case series. Results: Five patients (I I to 18 months of age) with button batteries trapped in the cervical esophagus were recently managed at our institution. The batteries were lodged in the esophagus for durations ranging from 6 hours to 4 months. Three cases of initial grade III circumferential necrotic injury were downgraded to grade IIa after a CSLE performed 2 to 4 days after removal, and their management was appropriately changed. Conclusions: The injury and healing of cases of button batteries in the proximal esophagus appear to be variable; caustic injury, electrical mucosal damage, and direct pressure are thought to be several contributory factors. Performing a CSLE within 2 to 4 days after battery removal may provide more useful prognostic information. In certain cases, downgrading of the injury may facilitate an earlier return to an oral diet, use of fewer diagnostic tests, and a shorter hospital stay. The utility and timing of imaging, management of diet and medications, and acceptable follow-up plans are discussed within the context of guiding future research. C1 [Ruhl, Douglas S.; Cable, Benjamin B.; Rieth, Katherine K. S.] Tripler Army Med Ctr, Dept Otolaryngol Head & Neck Surg, Honolulu, HI 96859 USA. RP Ruhl, DS (reprint author), Tripler Army Med Ctr, Dept Otolaryngol Head & Neck Surg, Attn MCHK DSH, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM douglas.s.ruhl.mil@mail.mil CR Baskin D, 2004, PEDIATR SURG INT, V20, P824, DOI 10.1007/s00383-004-1294-4 Bicakci U, 2010, PEDIATR SURG INT, V26, P251, DOI 10.1007/s00383-009-2525-5 Chang Yi-Jung, 2004, Chang Gung Med J, V27, P673 Cheng HT, 2008, BMC GASTROENTEROL, V8, DOI 10.1186/1471-230X-8-31 Dawe N, 2013, J LARYNGOL OTOL, V127, P84, DOI 10.1017/S0022215112002617 Karagiozoglou-Lampoudi T, 2011, DIS ESOPHAGUS, V24, P86, DOI 10.1111/j.1442-2050.2010.01097.x Kay M, 2009, CURR OPIN PEDIATR, V21, P651, DOI 10.1097/MOP.0b013e32832e2764 Kimball SJ, 2010, ARCH OTOLARYNGOL, V136, P866, DOI 10.1001/archoto.2010.146 Lin VYW, 2004, INT J PEDIATR OTORHI, V68, P473, DOI 10.1016/j.ijporl.2003.10.020 Litovitz T, 2010, PEDIATRICS, V125, P1178, DOI 10.1542/peds.2009-3038 LITOVITZ T, 1992, PEDIATRICS, V89, P747 Litovitz T, 2010, PEDIATRICS, V125, P1168, DOI 10.1542/peds.2009-3037 Marom T, 2010, INT J PEDIATR OTORHI, V74, P849, DOI 10.1016/j.ijporl.2010.05.019 Mirshemirani AR, 2012, MIDDLE E J DIG DIS, V4, P107 Tanaka J, 1998, VET HUM TOXICOL, V40, P193 YAMASHLTA M, 1987, VET HUM TOXICOL, V29, P226 Yardeni D, 2004, PEDIATR SURG INT, V20, P496, DOI 10.1007/s00383-004-1223-6 Yoshikawa T, 1997, CRIT CARE MED, V25, P2039, DOI 10.1097/00003246-199712000-00022 NR 18 TC 0 Z9 0 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD MAR PY 2014 VL 123 IS 3 BP 206 EP 213 DI 10.1177/0003489414522969 PG 8 WC Otorhinolaryngology SC Otorhinolaryngology GA AC3QQ UT WOS:000332436700007 PM 24633947 ER PT J AU Sidell, DR Nassar, M Cotton, RT Zeitels, SM de Alarcon, A AF Sidell, Douglas R. Nassar, Michel Cotton, Robin T. Zeitels, Steven M. de Alarcon, Alessandro TI High-Dose Sublesional Bevacizumab (Avastin) for Pediatric Recurrent Respiratory Papillomatosis SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article; Proceedings Paper CT Meeting of the American-Broncho-Esophagological-Association CY APR 10-11, 2013 CL Orlando, FL SP Amer Broncho Esophagol Assoc DE bevacizumab; papilloma; pediatrics; recurrent respiratory papillomatosis ID CHILDREN; SYSTEM; LASER AB Objectives: We review and report the use of high-dose bevacizumab for the treatment of recurrent respiratory papillomatosis (RRP) in pediatric patients. Methods: We included all patients with pediatric-onset RRP who underwent bevacizumab (25 mg/mL) injections by a single practitioner. A series of 5 consecutive subepithelial injections were administered at 4- to 6-week intervals with concomitant 532 nm KTP laser ablation. The lesions were staged according to the Derkay staging system. The outcomes included pretreatment and posttreatment Derkay scores, the time interval between procedures, and voice outcomes. The demographic data extracted included sex, age at diagnosis, and current age. Results: Nine patients were included in this study, with 1 patient lost to follow-up; their median age was 8 years (range, 3 to 21 years). The mean bevacizumab dose was 14.25 mg (range, 5 to 45 mg). There was a median Derkay score of 11.5 (range, 4 to 23) at the time of diagnosis and a median 58% improvement following therapy. All patients demonstrated an increased time interval between injections, for a median improvement of 2.05x (range, 1.6x to 3.25x). Conclusions: Evidence exists in support of vascular endothelial growth factor as an important factor in the development of RRP. Although some variability in response is demonstrated by this study, high-dose bevacizumab appears to yield promising results for pediatric patients with RRP. C1 [Sidell, Douglas R.; Nassar, Michel; Cotton, Robin T.; de Alarcon, Alessandro] Cincinnati Childrens Hosp Med Ctr, Div Pediat Otolaryngol Head & Neck Surg, Cincinnati, OH 45229 USA. [de Alarcon, Alessandro] Univ Cincinnati, Coll Med, Dept Otolaryngol Head & Neck Surg, Cincinnati, OH USA. [Zeitels, Steven M.] Massachusetts Gen Hosp, Ctr Laryngeal Surg & Voice Rehabil, Boston, MA 02114 USA. [Zeitels, Steven M.] Harvard Univ, Sch Med, Dept Surg, Boston, MA 02115 USA. RP de Alarcon, A (reprint author), Cincinnati Childrens Hosp Med Ctr, Div Pediat Otolaryngol Head & Neck Surg, 3333 Burnet Ave,MLC 2018, Cincinnati, OH 45229 USA. EM alessandro.dealarcon@cchmc.org CR Best SR, 2012, ANN OTO RHINOL LARYN, V121, P587 Chadha NK, 2012, COCHRANE DB SYST REV, V12 Derkay CS, 1998, LARYNGOSCOPE, V108, P935, DOI 10.1097/00005537-199806000-00026 Derkay CS, 2013, LARYNGOSCOPE, V123, P705, DOI 10.1002/lary.23673 Derkay CS, 2008, LARYNGOSCOPE, V118, P1236, DOI 10.1097/MLG.0b013e31816a7135 Eskens FALM, 2008, EUR J CANCER, V44, P2350, DOI 10.1016/j.ejca.2008.07.042 FOLKMAN J, 1971, NEW ENGL J MED, V285, P1182 Hays SR, 2011, CURR NEUROL NEUROSCI, V11, P205, DOI 10.1007/s11910-010-0177-4 Hester RP, 2003, INT J PEDIATR OTORHI, V67, P505, DOI 10.1016/S0165-5876(03)00007-7 Johnson K, 2011, ARCH OTOLARYNGOL, V137, P1258, DOI 10.1001/archoto.2011.193 Kalkman CJ, 2009, ANESTHESIOLOGY, V110, P805, DOI 10.1097/ALN.0b013e31819c7124 Maturo S, 2010, ARCH OTOLARYNGOL, V136, P561, DOI 10.1001/archoto.2010.81 Pediatric Expertise for Advisory Panels, 2003, GUID IND FDA STAFF Stewart MW, 2013, MAYO CLIN PROC, V88, P305, DOI 10.1016/j.mayocp.2012.12.007 Zeitels SM, 2011, ANN OTO RHINOL LARYN, V120, P627 Zeitels SM, 2009, ANN OTOL RHINOL S201, V118, P1 NR 16 TC 3 Z9 3 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD MAR PY 2014 VL 123 IS 3 BP 214 EP 221 DI 10.1177/0003489414522977 PG 8 WC Otorhinolaryngology SC Otorhinolaryngology GA AC3QQ UT WOS:000332436700008 PM 24633948 ER PT J AU Motz, KM Nickley, KB Bedwell, JR Yadav, B Guzzetta, PC Oh, AK Bauman, NM AF Motz, Kevin M. Nickley, Katherine B. Bedwell, Joshua R. Yadav, Bhupender Guzzetta, Philip C. Oh, Albert K. Bauman, Nancy M. TI OK432 Versus Doxycycline for Treatment of Macrocystic Lymphatic Malformations SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE doxycycline; lymphatic malformation; OK432; sclerotherapy ID PERCUTANEOUS SCLEROTHERAPY; OK-432 THERAPY; CYSTIC LYMPHANGIOMAS; PICIBANIL OK-432; PEDIATRIC HEAD; NECK; CHILDREN; EXPERIENCE; INJECTION; EFFICACY AB Objectives: A variety of sclerotherapy agents are used to treat macrocystic lymphatic malformations (LMs). This retrospective study at a single institution was performed to compare the outcomes of pediatric macrocystic LMs of the head and neck that were treated with doxycycline or with OK432. Methods: The outcomes measured included early response to therapy, number of treatments required, operating room time, and adverse events. Results: The rates of clinical success for OK432 and doxycycline were similar (83% and 82%, respectively; p > 0.05), although OK432-treated patients required more treatments than did doxycycline-treated patients (1.9 versus 1.0 injections; p = 0.01; 95% confidence interval, 1.57 to 0.27). The average operating room time for a single OK432 injection was significantly shorter than that for doxycycline (53.2 versus 98.1 minutes; p < 0.001); however, when the total number of treatments administered was considered, the overall times in the operating room were similar. Adverse events in the early postoperative period were more common in OK432-treated patients, who experienced marked postoperative swelling compared to doxycycline-treated patients. Conclusions: OK432 and doxycycline are both effective sclerosants for the treatment of predominantly macrocystic LMs. The administration time for OK432 is shorter than that for doxycycline, but OK432 required more treatments overall to achieve clinical success. Early adverse events were more common in OK432-treated patients, but longer follow-up is necessary to determine whether rates of recurrence and adverse events are similar, particularly in light of the risk of tooth discoloration in doxycycline-treated patients. C1 [Motz, Kevin M.; Nickley, Katherine B.] Georgetown Univ, Sch Med, Washington, DC USA. [Bedwell, Joshua R.; Bauman, Nancy M.] George Washington Univ, Childrens Natl Med Ctr, Sch Med, Div Otolaryngol, Washington, DC USA. [Yadav, Bhupender] George Washington Univ, Childrens Natl Med Ctr, Sch Med, Dept Radiol, Washington, DC USA. [Guzzetta, Philip C.] George Washington Univ, Childrens Natl Med Ctr, Sch Med, Dept Pediat Surg, Washington, DC USA. [Oh, Albert K.] George Washington Univ, Childrens Natl Med Ctr, Sch Med, Div Plast Surg, Washington, DC USA. RP Bauman, NM (reprint author), Childrens Natl Med Ctr, Div Otolaryngol, 111 Michigan Ave, Washington, DC 20010 USA. CR Alomari AI, 2006, J VASC INTERV RADIOL, V17, P1639, DOI 10.1097/01.RVI.0000239104.78390.E5 [Anonymous], 2012, DOX PREC MICR 2 0 WE Balakrishnan K, 2012, OTOLARYNG HEAD NECK, V147, P925, DOI 10.1177/0194599812450838 Bloom David C, 2004, Curr Opin Otolaryngol Head Neck Surg, V12, P500, DOI 10.1097/01.moo.0000143971.19992.2d Burrows Patricia E., 2008, Lymphatic Research and Biology, V6, P209, DOI 10.1089/lrb.2008.1004 Cahill AM, 2011, J PEDIATR SURG, V46, P2083, DOI 10.1016/j.jpedsurg.2011.07.004 Castanon M, 1999, J PEDIATR SURG, V34, P1276, DOI 10.1016/S0022-3468(99)90168-9 Churchill P, 2011, J PEDIATR SURG, V46, P912, DOI 10.1016/j.jpedsurg.2011.02.027 Claesson G, 2012, 19 INT SOC STUD VASC, P167 Claesson G, 2002, INT J PEDIATR OTORHI, V65, P1, DOI 10.1016/S0165-5876(02)00117-9 Cordes BM, 2007, OTOLARYNG HEAD NECK, V137, P962, DOI 10.1016/j.otohns.2007.08.013 DESERRES LM, 1995, ARCH OTOLARYNGOL, V121, P577 EMERY PJ, 1984, J LARYNGOL OTOL, V98, P613, DOI 10.1017/S0022215100147176 Ezekowitz RA, 1995, NEW ENGL J MED, V333, P595 EZEKOWITZ RAB, 1994, NEW ENGL J MED, V330, P300 EZEKOWITZ RAB, 1992, NEW ENGL J MED, V326, P1456, DOI 10.1056/NEJM199205283262203 FORTI G, 1969, LANCET, V1, P782 Fujino A, 2003, J PEDIATR SURG, V38, P1806, DOI 10.1016/S0022-3468(03)00639-0 Giguere CM, 2002, ARCH OTOLARYNGOL, V128, P1137 Greinwald JH, 1999, OTOLARYNG HEAD NECK, V121, P381, DOI 10.1016/S0194-5998(99)70225-1 HERBRETEAU D, 1993, INT ANGIOL, V12, P34 Hoff DS, 2007, PHARMACOTHERAPY, V27, P995, DOI 10.1592/phco.27.7.995 ICHIMURA O, 1985, INT J IMMUNOPHARMACO, V7, P263 Ishida N, 1985, STREPTOCOCCAL PREPAR, P70 Jain R, 2002, J CLIN ULTRASOUND, V30, P416, DOI 10.1002/jcu.10091 Jamal N, 2012, INT J PEDIATR OTORHI, V76, P1127, DOI 10.1016/j.ijporl.2012.04.015 Martinot V, 1997, ARCH PEDIATRIE, V4, P8, DOI 10.1016/S0929-693X(97)84296-0 MOLITCH HI, 1995, RADIOLOGY, V194, P343 Nehra D, 2008, J PEDIATR SURG, V43, P451, DOI 10.1016/j.jpedsurg.2007.10.009 OGITA S, 1991, J PEDIATR SURG, V26, P263, DOI 10.1016/0022-3468(91)90500-S Ogita S, 1996, J PEDIATR SURG, V31, P477, DOI 10.1016/S0022-3468(96)90478-9 Rautio R, 2003, CARDIOVASC INTER RAD, V26, P31, DOI 10.1007/s00270-002-1980-3 SAITO M, 1982, CELL IMMUNOL, V68, P187, DOI 10.1016/0008-8749(82)90102-2 Shergill A, 2012, PEDIATR RADIOL, V42, P1080, DOI 10.1007/s00247-012-2406-2 Sichel JY, 2004, LARYNGOSCOPE, V114, P1805, DOI 10.1097/00005537-200410000-00024 Smith MC, 2009, LARYNGOSCOPE, V119, P107, DOI 10.1002/lary.20041 Smith Richard J H, 2004, Lymphat Res Biol, V2, P25, DOI 10.1089/1539685041690436 Smith RJH, 1996, ARCH OTOLARYNGOL, V122, P1195 Sung MW, 2001, LARYNGOSCOPE, V111, P1430, DOI 10.1097/00005537-200108000-00020 TANIGAWA N, 1987, CANCER, V60, P741, DOI 10.1002/1097-0142(19870815)60:4<741::AID-CNCR2820600406>3.0.CO;2-2 US Department of Health and Human Services National Institute of Health National Cancer Institute, COMM TERM CRIT ADV E Volovitz B, 2007, CLIN PEDIATR, V46, P121, DOI 10.1177/0009922806290026 Won JH, 2004, J VASE INTERV RADIOL, V15, P874 Won JH, 2004, J VASC INTERV RADIOL, V15, P595, DOI 10.1097/01.RVI.0000127899.31047.0E Zhong PQ, 1998, ORAL SURG ORAL MED O, V86, P139 Zhou Q, 2011, ORAL ONCOL, V47, P1105, DOI 10.1016/j.oraloncology.2011.08.001 NR 46 TC 0 Z9 0 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD FEB PY 2014 VL 123 IS 2 BP 81 EP 88 DI 10.1177/0003489414523561 PG 8 WC Otorhinolaryngology SC Otorhinolaryngology GA AB6TY UT WOS:000331923600001 PM 24574462 ER PT J AU Quaranta, N Iannuzzi, L Petrone, P D'Elia, A Quaranta, A AF Quaranta, Nicola Iannuzzi, Lucia Petrone, Paolo D'Elia, Alessandra Quaranta, Antonio TI Quality of Life After Cholesteatoma Surgery: Intact-Canal Wall Tympanoplasty Versus Canal Wall-Down Tympanoplasty With Mastoid Obliteration SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE cholesteatoma surgery; mastoid obliteration; quality of life; tympanoplasty ID OTITIS-MEDIA; OUTCOMES; TYMPANOMASTOIDECTOMY; RECONSTRUCTION; CAVITY AB Objectives: The aim of this study was to evaluate, by means of the Chronic Ear Survey (CES), the quality of life of patients who had undergone either intact canal wall tympanoplasty (ICWT) or canal wall down tympanoplasty (CWDT) with mastoid obliteration. Methods: This was a retrospective case review study performed at a tertiary referral center. Among 379 patients affected by middle ear and mastoid cholesteatoma operated on between November 2000 and December 2009, 50 patients who underwent ICWT and 50 who underwent CWDT with mastoid obliteration were randomly selected. The CES scores were analyzed for both groups. Results: The mean scores on the CES were 6.5 +/- 2.1 in patients who underwent CWDT and 6.9 +/- 2.2 in patients treated with ICWT (t = -0.93; p > 0.05). No significant differences between the two groups were found on the activity restriction, symptom, or medical resource subscales (p > 0.05). Conclusions: The results of this study demonstrate that CWDT with mastoid obliteration resulted in a quality of life comparable with that after ICWT. Postoperative hearing loss is the most frequently reported problem for both techniques. C1 [Quaranta, Nicola; Iannuzzi, Lucia; Petrone, Paolo; D'Elia, Alessandra; Quaranta, Antonio] Univ Bari, Otolaryngol Sect, Dept Basic Med Sci Neurosci & Sensory Organs, Bari, Italy. RP Quaranta, N (reprint author), Univ Policlin Bari, Pzza G Cesare 11, I-70124 Bari, Italy. CR Black Bruce, 1998, American Journal of Otology, V19, P551 Cho SW, 2012, CLIN EXP OTORHINOLAR, V5, P23, DOI 10.3342/ceo.2012.5.1.23 De Foer B, 2008, OTOL NEUROTOL, V29, P513, DOI 10.1097/MAO.0b013e31816c7c3b Dornhoffer JL, 1999, OTOLARYNG HEAD NECK, V120, P361, DOI 10.1016/S0194-5998(99)70276-7 Gantz BJ, 2005, LARYNGOSCOPE, V115, P1734, DOI 10.1097/01.MLG.0000187572.99335.cc Graham MD, 1999, OTOLARYNG CLIN N AM, V32, P547, DOI 10.1016/S0030-6665(05)70151-1 Grote JJ, 1998, AM J OTOL, V19, P565 Iniguez-Cuadra R, 2010, OTOL NEUROTOL, V31, P409, DOI 10.1097/MAO.0b013e3181cc04b5 KARMARKAR S, 1995, ANN OTO RHINOL LARYN, V104, P591 Kim MB, 2010, CLIN EXP OTORHINOLAR, V3, P203, DOI 10.3342/ceo.2010.3.4.203 Nadol JB, 2000, LARYNGOSCOPE, V110, P32, DOI 10.1097/00005537-200003002-00009 PALVA T, 1973, ACTA OTO-LARYNGOL, V75, P289, DOI 10.3109/00016487309139718 QUARANTA A, 1988, AM J OTOL, V9, P229 SADE J, 1982, J LARYNGOL OTOL, V96, P869, DOI 10.1017/S0022215100093221 SHEA M C JR, 1972, Transactions of the American Academy of Ophthalmology and Oto-Laryngology, V76, P160 SMYTH GDL, 1985, LARYNGOSCOPE, V95, P92 TOS M, 1989, Auris Nasus Larynx, V16, P61 Wang PC, 2000, ANN OTO RHINOL LARYN, V109, P249 NR 18 TC 1 Z9 1 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD FEB PY 2014 VL 123 IS 2 BP 89 EP 93 DI 10.1177/0003489414523562 PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA AB6TY UT WOS:000331923600002 PM 24574463 ER PT J AU Oyer, SL Fritsch, VA Lentsch, EJ AF Oyer, Sam L. Fritsch, Valerie A. Lentsch, Eric J. TI Comparison of Survival Rates Between Papillary and Follicular Thyroid Carcinomas Among 36,725 Patients SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE follicular thyroid carcinoma; papillary thyroid carcinoma; SEER database; survival ID PROGNOSTIC-FACTORS; STAGING SYSTEMS; CANCER; INSTITUTION AB Objectives: We sought to determine the impact of histologic subtype on disease-specific survival (DSS) in cases of differentiated thyroid carcinoma. Methods: Adult patients with papillary thyroid carcinoma (PTC) or follicular thyroid carcinoma (FTC) were identified from the Surveillance, Epidemiology, and End Results (SEER) Database for the years 1988 to 2003. The patients were grouped according to tumor type (PTC or FTC), and their age, gender, tumor size and extension, and nodal or distant metastases were recorded. The Kaplan-Meier method was used to compare DSS rates on the basis of histologic subtype. Results: We identified 36,725 patients, of whom 77% were female and 23% were male; PTC was diagnosed in 91% of patients, and FTC in the remaining 9%. Patients with PTC were younger, were more likely to be female, and had smaller tumors with higher rates of regional metastases but fewer distant metastases than FTC patients (p < 0.0001 for all). When the cases were stratified by stage, FTC patients had a worse DSS than did PTC patients for all stages - except for stages III/IVA and IVC among patients more than 45 years of age. Conclusions: Follicular thyroid carcinoma portends a worse DSS than does PTC, even when the cases are controlled for stage. Consideration should be given to individual staging for these subtypes of differentiated thyroid carcinoma. C1 [Oyer, Sam L.; Fritsch, Valerie A.; Lentsch, Eric J.] Med Univ S Carolina, Dept Otolaryngol Head & Neck Surg, Charleston, SC 29425 USA. [Lentsch, Eric J.] Med Univ S Carolina, Hollings Canc Ctr, Charleston, SC 29425 USA. RP Lentsch, EJ (reprint author), 135 Rutledge Ave,MSC 550, Charleston, SC 29425 USA. CR Aldred MA, 2004, J CLIN ONCOL, V22, P3531, DOI 10.1200/JCO.2004.08.127 D'Avanzo A, 2004, CANCER, V100, P1123, DOI 10.1002/cncr.20081 Edge S., 2010, AJCC CANC STAGING MA, V7th Elisei R, 2010, J CLIN ENDOCR METAB, V95, P1516, DOI 10.1210/jc.2009-1536 Gulcelik MA, 2007, J SURG ONCOL, V96, P598, DOI 10.1002/jso.20845 Ito Y, 2009, ENDOCR J, V56, P177 Jemal A, 2007, CA-CANCER J CLIN, V57, P43 Lang BHH, 2007, ANN SURG ONCOL, V14, P730, DOI 10.1245/s10434-006-9207-5 Lang BHH, 2007, ANN SURG, V245, P366, DOI 10.1097/01.sla.0000250445.92336.2a Mazzaferri E L, 2001, Endocr Pract, V7, P139 National Cancer Institute, 2012, NIH PUBLICATION, P12 Pacini F, 2012, MED CLIN N AM, V96, P369, DOI 10.1016/j.mcna.2012.01.002 Passler C, 2003, ANN SURG, V237, P227, DOI 10.1097/00000658-200302000-00012 Riesco-Eizaguirre G, 2007, ENDOCR-RELAT CANCER, V14, P957, DOI 10.1677/ERC-07-0085 Sciuto R, 2009, ANN ONCOL, V20, P1728, DOI 10.1093/annonc/mdp050 Steinmuller T, 2000, EUR J SURG, V166, P29, DOI 10.1080/110241500750009663 Tseng WH, 2011, J SURG RES, V167, P192, DOI 10.1016/j.jss.2010.10.008 Witt Robert L, 2002, Ear Nose Throat J, V81, P856 Zhao Y, 2012, TUMORI, V98, P233, DOI 10.1700/1088.11935 NR 19 TC 1 Z9 1 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD FEB PY 2014 VL 123 IS 2 BP 94 EP 100 DI 10.1177/0003489414523563 PG 7 WC Otorhinolaryngology SC Otorhinolaryngology GA AB6TY UT WOS:000331923600003 PM 24574464 ER PT J AU Gourin, CG Couch, ME Johnson, JT AF Gourin, Christine G. Couch, Marion E. Johnson, Jonas T. TI Effect of Weight Loss on Short-Term Outcomes and Costs of Care After Head and Neck Cancer Surgery SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE complication; dysphagia; head and neck neoplasms; malnutrition; Nationwide Inpatient Sample; surgery; weight loss ID QUALITY-OF-LIFE; NUTRITIONAL-STATUS; ENTERAL NUTRITION; SURVIVAL; MALNUTRITION; CACHEXIA; DISPARITIES; MORBIDITY; MORTALITY; VOLUME AB Objectives: Patients with head and neck cancer (HNC) frequently present with weight loss secondary to dysphagia and malnutrition. We sought to determine the relationship between weight loss and in-hospital mortality, complications, length of hospitalization, and costs in HNC surgery. Methods: We analyzed discharge data from the Nationwide Inpatient Sample for 93,663 patients who underwent an ablative procedure for malignant oral cavity, laryngeal, hypopharyngeal, or oropharyngeal neoplasms between 2003 and 2008. Results: Weight loss was significantly associated with dysphagia (relative risk ratio [RRR] = 3.0; p < 0.001), alcohol abuse (RRR = 2.0; p < 0.001), advanced comorbidity (RRR = 1.8; p < 0.001), Medicaid payor status (RRR = 1.6; p = 0.002), urgent or emergent admission (RRR = 1.7; p = 0.015), and major surgical procedures (RRR = 2.3; p <0.001). Patients with weight loss had increased risks of acute cardiac events, pneumonia, renal failure, sepsis, pulmonary failure (RRR = 2.6; p < 0.001), and postoperative wound healing complications, including fistula, dehiscence, and surgical site infection (RRR = 2.0; p < 0.001). After we controlled for all other variables, weight loss was associated with significantly increased length of hospitalization and hospital-related costs. Conclusions: Weight loss is associated with increases in medical complications, surgical complications, length of hospitalization, and hospital-related costs in HNC surgical patients. Aggressive preoperative identification and treatment of underlying dysphagia and malnutrition may reduce the medical and surgical morbidity in this high-risk population. C1 [Gourin, Christine G.] Johns Hopkins Univ, Dept Otolaryngol Head & Neck Surg, Baltimore, MD USA. [Couch, Marion E.] Univ Vermont, Dept Surg, Burlington, VT 05405 USA. [Johnson, Jonas T.] Univ Pittsburgh, Med Ctr, Dept Otolaryngol Head & Neck Surg, Pittsburgh, PA USA. RP Gourin, CG (reprint author), Johns Hopkins Outpatient Ctr, Dept Otolaryngol Head & Neck Surg, 601 N Caroline St,Suite 6260, Baltimore, MD 21287 USA. CR Antoun S, 2009, WORLD J SURG, V33, P1633, DOI 10.1007/s00268-009-0033-3 Bianchini C, 2012, EUR ARCH OTO-RHINO-L, V269, P5, DOI 10.1007/s00405-011-1725-5 Buijs N, 2010, AM J CLIN NUTR, V92, P1151, DOI 10.3945/ajcn.2010.29532 Casas-Rodera P, 2008, NUTR HOSP, V23, P105 CHARLSON ME, 1987, J CHRON DIS, V40, P373, DOI 10.1016/0021-9681(87)90171-8 Couch M, 2007, HEAD NECK-J SCI SPEC, V29, P401, DOI 10.1002/hed.20447 da Cruz ED, 2012, EUR J ONCOL NURS, V16, P253, DOI 10.1016/j.ejon.2011.06.002 Datema FR, 2011, ORAL ONCOL, V47, P910, DOI 10.1016/j.oraloncology.2011.06.510 de Luis DA, 2007, EUR J CLIN NUTR, V61, P200, DOI 10.1038/sj.ejcn.1602515 Drover JW, 2011, J AM COLL SURGEONS, V212, P385, DOI 10.1016/j.jamcollsurg.2010.10.016 Drover JW, 2011, J AM COLL SURGEONS, V212 Felekis D, 2010, NUTR CANCER, V62, P1105, DOI 10.1080/01635581.2010.494336 Gupta D, 2011, ANN NUTR METAB, V59, P96, DOI 10.1159/000332914 Jager-Wittenaar H, 2011, SUPPORT CARE CANCER, V19, P1675, DOI 10.1007/s00520-010-1001-z Jager-Wittenaar H, 2011, HEAD NECK-J SCI SPEC, V33, P863, DOI 10.1002/hed.21546 Liu JH, 2006, JAMA-J AM MED ASSOC, V296, P1973, DOI 10.1001/jama.296.16.1973 Neighbors CJ, 2007, MED CARE, V45, P655, DOI 10.1097/MLR.0b013e3180326110 Newhouse Robin P, 2003, Int J Integr Care, V3, pe15 Nguyen TV, 2002, CANCER, V95, P553, DOI 10.1002/cncr.10711 Palesty JA, 2011, SURG CLIN N AM, V91, P653, DOI 10.1016/j.suc.2011.02.007 Petruson KM, 2005, HEAD NECK-J SCI SPEC, V27, P302, DOI 10.1002/hed.20172 Ravasco P, 2003, RADIOTHER ONCOL, V67, P213, DOI 10.1016/S0167-8140(03)00040-9 Richey LM, 2007, CLIN CANCER RES, V13, P6561, DOI 10.1158/1078-0432.CCR-07-0116 ROMANO PS, 1993, J CLIN EPIDEMIOL, V46, P1075, DOI 10.1016/0895-4356(93)90103-8 Romano PS, 1993, J CLIN EPIDEMIOL, V46, P1081 Stableforth WD, 2009, INT J ORAL MAX SURG, V38, P103, DOI 10.1016/j.ijom.2008.12.008 US Department of Labor Bureau of Labor Statistics, CONS PRIC IND INFL C vanBokhorstdevanderSchueren MAE, 1997, HEAD NECK-J SCI SPEC, V19, P419, DOI 10.1002/(SICI)1097-0347(199708)19:5<419::AID-HED9>3.0.CO;2-2 van Bokhorst-de van der Schueren MAE, 2001, AM J CLIN NUTR, V73, P323 NR 29 TC 0 Z9 0 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD FEB PY 2014 VL 123 IS 2 BP 101 EP 110 DI 10.1177/0003489414523564 PG 10 WC Otorhinolaryngology SC Otorhinolaryngology GA AB6TY UT WOS:000331923600004 PM 24574465 ER PT J AU Bryant, L Goodmurphy, CW Han, JK AF Bryant, Lucas Goodmurphy, Craig W. Han, Joseph K. TI Endoscopic and Three-Dimensional Radiographic Imaging of the Pterygopalatine and Infratemporal Fossae: Improving Surgical Landmarks SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE foramen ovale; infratemporal fossa; internal maxillary artery; pterygopalatine fossa; sphenopalatine artery; vidian canal ID LATERAL PTERYGOID MUSCLE; SPHENOPALATINE ARTERY; ENDONASAL APPROACH; MAXILLARY ARTERY; SKULL BASE; ANATOMY AB Objectives: We sought to define the surgical endoscopic anatomy of the pterygopalatine fossa (PPF) and infratemporal fossa (ITF) through endoscopic cadaver dissections and radiographic imaging analysis. Methods: Eleven fresh cadavers were submitted to computed tomography (CT) and endoscopic dissection. We used 3-di-mensional (3-D) CT reconstruction and endoscopic video imaging for analysis of the bony and soft tissue landmarks. One fixed cadaver head was grossly dissected to confirm the endoscopic anatomic findings. Results: The CT and 3-D CT reconstruction measurements between the pterygoid canal and the foramen rotundum averaged 4.36 mm and 5.09 mm, respectively. An osseous ridge (pterygoid ridge) was identified on the anterior face of the pterygoid process as a novel identifiable anatomic landmark in all of the specimens. The average length of the pterygoid ridge on 3-D CT reconstruction was 7.84 mm. The internal maxillary artery entered the PPF posteromedial to the temporalis tendon and anterolateral to the lateral pterygoid muscle. The average distance from the anterior edge of the lateral pterygoid plate to the foramen ovale was 17.1 mm. Conclusions: The pterygoid ridge is a novel and reliable osseous landmark that could assist surgeons during endoscopic surgery on the PPF and ITF. The neurovascular and muscular anatomic relationships were characterized for both the PPF and the ITF. C1 [Bryant, Lucas; Han, Joseph K.] Eastern Virginia Med Sch, Dept Otolaryngol Head & Neck Surg, Norfolk, VA 23507 USA. [Goodmurphy, Craig W.] Eastern Virginia Med Sch, Dept Anat & Pathol, Norfolk, VA 23507 USA. RP Han, JK (reprint author), Eastern Virginia Med Sch, 600 Gresham Dr,Suite 1100, Norfolk, VA 23507 USA. CR Alfieri A, 2003, NEUROSURGERY, V52, P374, DOI 10.1227/01.NEU.0000044562.73763.00 Dennison J, 2009, ORAL SURG ORAL MED O, V108, pE26, DOI 10.1016/j.tripleo.2009.07.029 Eloy JA, 2009, LARYNGOSCOPE, V119, P834, DOI 10.1002/lary.20186 Fagan JJ, 1997, HEAD NECK-J SCI SPEC, V19, P391, DOI 10.1002/(SICI)1097-0347(199708)19:5<391::AID-HED5>3.0.CO;2-V Fortes FSG, 2008, LARYNGOSCOPE, V118, P44, DOI 10.1097/MLG.0b013e318155a492 Hussain A, 2008, ORAL SURG ORAL MED O, V105, P32, DOI 10.1016/j.tripleo.2007.04.010 Isaacs SJ, 2007, AM J RHINOL, V21, P644, DOI 10.2500/ajr.2007.21.3085 Lee SC, 2008, CLIN EXP OTORHINOLAR, V1, P53, DOI 10.3342/ceo.2008.1.2.53 Midilli R, 2009, AM J RHINOL ALLERGY, V23, pE38, DOI 10.2500/ajra.2009.23.3403 Simmen DB, 2006, AM J RHINOL, V20, P502, DOI 10.2500/ajr.2006.20.2928 Solari D, 2007, J NEUROSURG, V106, P157, DOI 10.3171/jns.2007.106.1.157 Tolosanaa SH, 2011, ACTA OTORRINOLARINGO, V62, P274 NR 12 TC 0 Z9 0 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD FEB PY 2014 VL 123 IS 2 BP 111 EP 116 DI 10.1177/0003489414523707 PG 6 WC Otorhinolaryngology SC Otorhinolaryngology GA AB6TY UT WOS:000331923600005 PM 24574466 ER PT J AU Starmer, HM Liu, Z Akst, LM Gourin, C AF Starmer, Heather M. Liu, Zaneta Akst, Lee M. Gourin, Christine TI Attendance in Voice Therapy: Can an Interdisciplinary Care Model Have an Impact? SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE dysphonia; interdisciplinary care; patient adherence; patient compliance; therapy attendance; voice therapy ID ADHERENCE; CANCER; DYSPHONIA; TRIAL AB Objectives: We sought to determine the effect of referral patterns on attendance in voice therapy. Methods: Patients who were seen by a laryngologist for vocal concerns and referred for voice therapy comprised the study population. Outcomes were compared between those who were initially evaluated through the interdisciplinary voice clinic (IDC), which combined speech-language pathology and laryngology care, and those who were evaluated by a laryngologist alone. Adherence was measured by completion of the plan of care. Results: There were 79 patients evaluated through the IDC and 100 patients evaluated initially by a laryngologist. Patients evaluated through the IDC had more visits with the speech-language pathologist (mean, 3.1 versus 1.24; p < 0.0001). Those initially evaluated through the IDC were more likely to complete their plan of care (p = 0.02). Completion of voice therapy was significantly more likely for individuals coded as being of "other" race (odds ratio, 7.98; p = 0.002) and for patients who participated in the IDC (odds ratio, 2.56; p = 0.018). The cause of dysphonia, sex, marital status, insurance status, days from laryngology referral to the initial speech-language pathologist consultation, the initial Voice-Related Quality of Life score, and distance to the clinic were not associated with patient attendance. Conclusions: Patients evaluated in a coordinated IDC should be more likely to attend voice therapy and complete their plan of care, regardless of other factors. C1 [Starmer, Heather M.; Liu, Zaneta; Akst, Lee M.; Gourin, Christine] Johns Hopkins Med Inst, Dept Otolaryngol Head & Neck Surg, Baltimore, MD 21287 USA. RP Starmer, HM (reprint author), Johns Hopkins Med Inst, Dept Otolaryngol Head & Neck Surg, 601 N Caroline St,Suite 6260, Baltimore, MD 21287 USA. CR Hall AM, 2010, PHYS THER, V90, P1099, DOI 10.2522/ptj.20090245 Hapner E, 2009, J VOICE, V23, P337, DOI 10.1016/j.jvoice.2007.10.009 Hillen MA, 2011, PSYCHO-ONCOLOGY, V20, P227, DOI 10.1002/pon.1745 Hogikyan ND, 1999, J VOICE, V13, P557, DOI 10.1016/S0892-1997(99)80010-1 Kosmider S, 2010, INTERN MED J, V40, P757, DOI 10.1111/j.1445-5994.2009.01986.x MacKenzie K, 2001, BRIT MED J, V323, P658, DOI 10.1136/bmj.323.7314.658 Matthews EE, 2012, BEHAV SLEEP MED, V10, P217, DOI 10.1080/15402002.2012.666220 Murdock A, 2002, J ROY SOC MED, V95, P284, DOI 10.1258/jrsm.95.6.284 NOEL SB, 1989, J CLIN PSYCHOL, V45, P798, DOI 10.1002/1097-4679(198909)45:5<798::AID-JCLP2270450517>3.0.CO;2-C Portone C, 2008, J VOICE, V22, P192, DOI 10.1016/j.jvoice.2006.09.009 Portone-Maira C, 2011, J VOICE, V25, P62, DOI 10.1016/j.jvoice.2009.07.007 Ramig LO, 1998, J SPEECH LANG HEAR R, V41, pS101 Scott S, 1997, CLIN OTOLARYNGOL, V22, P37, DOI 10.1046/j.1365-2273.1997.00855.x Starmer H, 2011, LARYNGOSCOPE, V121, P2131, DOI 10.1002/lary.21746 Theim KR, 2013, OBESITY, V21, P394, DOI [10.1002/oby.20281, 10.1038/oby.2012.94] Thomas LB, 2007, COMMUNICATIVE DISORD, V1, P51 van Leer E, 2010, J VOICE, V24, P458, DOI 10.1016/j.jvoice.2008.12.009 VERDOLINIMARSTON K, 1995, J VOICE, V9, P74, DOI 10.1016/S0892-1997(05)80225-5 NR 18 TC 1 Z9 1 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD FEB PY 2014 VL 123 IS 2 BP 117 EP 123 DI 10.1177/0003489414523708 PG 7 WC Otorhinolaryngology SC Otorhinolaryngology GA AB6TY UT WOS:000331923600006 PM 24574467 ER PT J AU Halum, SL Bijangi-Vishehsaraei, K Zhang, HJ Sowinski, J Bottino, MC AF Halum, Stacey L. Bijangi-Vishehsaraei, Khadijeh Zhang, Hongji Sowinski, John Bottino, Marco C. TI Stem Cell-Derived Tissue-Engineered Constructs for Hemilaryngeal Reconstruction SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE muscle progenitor cell; muscle stem cell; reconstruction; scaffold; tissue-engineered implant ID RECURRENT LARYNGEAL; NERVE INJURY; MUSCLE; AGRIN; REINNERVATION; MEMBRANE AB Objectives: As an initial step toward our goal of developing a completely tissue-engineered larynx, the aim of this study was to describe and compare three strategies of creating tissue-engineered muscle-polymer constructs for hemilaryngeal reconstruction. Methods: Cartilage-mimicking polymer was developed from electrospun poly(D,L-lactide-co-epsilon-caprolactone) (PCL). Primary muscle progenitor cell cultures were derived from syngeneic F344 rat skeletal muscle biopsies. Twenty F344 rats underwent resection of the outer hemilaryngeal cartilage with the underlying laryngeal adductor muscle. The defects were repaired with muscle stem cell-derived muscle-PCL constructs (5 animals), myotube-derived muscle-PCL constructs (5 animals), motor end plate-expressing muscle-PCL constructs (5 animals), or PCL alone (controls; 5 animals). The outcome measures at 1 month included animal survival, muscle thickness, and innervation status as determined by electromyography and immunohistochemistry. Results: All of the animals survived the 1-month implant period and had appropriate weight gain. The group that received motor end plate-expressing muscle-PCL constructs demonstrated the greatest muscle thickness and the strongest innervation, according to electromyographic activity and the percentage of motor end plates that had nerve contact. Conclusions: Although all of the tissue-engineered constructs provided effective reconstruction, those that expressed motor end plates before implantation yielded muscle that was more strongly innervated and viable. This finding suggests that this novel approach may be useful in the development of a tissue-engineered laryngeal replacement. C1 [Halum, Stacey L.; Bijangi-Vishehsaraei, Khadijeh; Zhang, Hongji; Sowinski, John] Indiana Univ Sch Med, Dept Otolaryngol Head & Neck Surg, Indianapolis, IN 46202 USA. [Bottino, Marco C.] Indiana Univ, Div Dent Biomat, Dept Restorat Dent, Sch Dent, Indiana, PA 46202 USA. RP Halum, SL (reprint author), Indiana Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, 950 W Walnut St,Res 2 Bldg,E425, Indianapolis, IN 46202 USA. FU National Institute on Deafness and Other Communication Disorders (NIDCD) within National Institutes of Health (NIH) [K08DC009583]; Project Development Team within ICTSI NIH/NCRR [TR000006]; Indiana University Collaborative Research Grant; Indiana University School of Medicine Center for Translational Science Institute (CTSI) FX From the Department of Otolaryngology Head and Neck Surgery, Indiana University School of Medicine (Halum, Bijangi-Vishehsaraei, Zhang, Sowinski), and the Department of Restorative Dentistry/Division of Dental Biomaterials, Indiana University School of Dentistry (Bottino), Indianapolis, Indiana. Drs Halum and Bijangi-Vishehsaraei contributed equally to the study. These projects were in part supported by award number K08DC009583 from the National Institute on Deafness and Other Communication Disorders (NIDCD) within the National Institutes of Health (NIH). These projects were supported in part by a Project Development Team within the ICTSI NIH/NCRR, grant TR000006. The content of this publication is solely the responsibility of the authors and does not necessarily represent the official views of the NIDCD or NIH. These projects were supported in part by an Indiana University Collaborative Research Grant. The projects were also in part supported by an award from the Indiana University School of Medicine Center for Translational Science Institute (CTSI). The authors completed these experiments in alignment with the ethical research guidelines of our institution and the NIH. This study was performed in accordance with the PHS Policy on Humane Care and Use of Laboratory Animals, the NIH Guide for the Care and Use of Laboratory Animals, and the Animal Welfare Act (7 U.S.C. et seq.); the animal use protocol was approved by the Institutional Animal Care and Use Committee (IACUC) of Indiana University. CR American Cancer Society, 2012, CANC FACTS FIG 2012 Blitzer A, 1996, ANN OTO RHINOL LARYN, V105, P764 Bottino MC, 2011, ACTA BIOMATER, V7, P216, DOI 10.1016/j.actbio.2010.08.019 Cohen I, 1997, MOL CELL NEUROSCI, V9, P237, DOI 10.1006/mcne.1997.0623 Halum SL, 2007, LARYNGOSCOPE, V117, P917, DOI 10.1097/MLG.0b013e31803e8c8d Halum SL, 2008, LARYNGOSCOPE, V118, P1308, DOI 10.1097/MLG.0b013e31816c438e Hydman J, 2008, MUSCLE NERVE, V38, P1280, DOI 10.1002/mus.21124 Inagi K, 1998, OTOLARYNG HEAD NECK, V118, P74, DOI 10.1016/S0194-5998(98)70378-X Jones G, 1997, P NATL ACAD SCI USA, V94, P2654, DOI 10.1073/pnas.94.6.2654 Kang SB, 2012, TISSUE ENG PT A, V18, P1912, DOI [10.1089/ten.TEA.2011.0225, 10.1089/ten.tea.2011.0225] Long JL, 2010, LARYNGOSCOPE, V120, P125, DOI 10.1002/lary.20719 Long JL, 2010, OTOLARYNG HEAD NECK, V142, P438, DOI 10.1016/j.otohns.2009.11.020 Ngo ST, 2012, J CELL SCI, V125, P1531, DOI 10.1242/jcs.095109 Peppard SB, 1983, ANN OTOL RHINOL LARY, V92 Vock VM, 2008, J NEUROSCI, V28, P3123, DOI 10.1523/JNEUROSCI.5080-07.2008 Woodson GE, 2007, ANN OTO RHINOL LARYN, V116, P57 Zhou WY, 2010, J BIOMED MATER RES A, V93A, P1574, DOI 10.1002/jbm.a.32656 NR 17 TC 0 Z9 0 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD FEB PY 2014 VL 123 IS 2 BP 124 EP 134 DI 10.1177/0003489414523709 PG 11 WC Otorhinolaryngology SC Otorhinolaryngology GA AB6TY UT WOS:000331923600007 PM 24574468 ER PT J AU Hohman, MH Lindsay, RW Pomerantseva, I Bichara, DA Zhao, X Johnson, M Kulig, KM Sundback, CA Randolph, MA Vacanti, JP Cheney, ML Hadlock, TA AF Hohman, Marc H. Lindsay, Robin W. Pomerantseva, Irina Bichara, David A. Zhao, Xing Johnson, Matthew Kulig, Katherine M. Sundback, Cathryn A. Randolph, Mark A. Vacanti, Joseph P. Cheney, Mack L. Hadlock, Theresa A. TI Ovine Model for Auricular Reconstruction: Porous Polyethylene Implants SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE microtia; porous polyethylene implant; sheep ID EAR RECONSTRUCTION; PERSONAL-EXPERIENCE; GORE-TEX; MICROTIA; AURICLE; MEDPOR AB Objectives: We developed a large animal model for auricular reconstruction with engineered cartilage frameworks and evaluated the performance of porous polyethylene auricular implants in this model. Methods: Eighteen high-density porous polyethylene auricular frameworks were implanted subcutaneously in the infraauricular areas of 9 sheep. The implants were harvested 17 weeks later for gross and histologic examination. The perioperative and postoperative courses were carefully documented. Results: Five implants became exposed, and 2 implants needed to be removed at 7 weeks. Additionally, 1 infected implant was removed at 2 weeks. Seromas developed in 2 implants because of drain failures and were drained successfully during the first postoperative week. There were no other surgical site complications. The remaining 10 implants had an acceptable cosmetic appearance at 17 weeks. Conclusions: The perioperative complication rate in the ovine porous polyethylene auricular implant model was higher than that reported for auricular reconstructions in humans. The implant exposures were likely caused by ischemia and excessive stress on the thin overlying skin, because vascularized flap coverage was not used. The histologic findings were comparable to the results reported for other animal models. This large animal model is appropriate for auricular reconstruction experiments, including engineered constructs. C1 [Hohman, Marc H.; Lindsay, Robin W.; Cheney, Mack L.; Hadlock, Theresa A.] Massachusetts Eye & Ear Infirm, Boston, MA 02114 USA. [Hohman, Marc H.; Lindsay, Robin W.; Pomerantseva, Irina; Bichara, David A.; Zhao, Xing; Sundback, Cathryn A.; Randolph, Mark A.; Vacanti, Joseph P.; Cheney, Mack L.; Hadlock, Theresa A.] Harvard Univ, Sch Med, Boston, MA USA. [Pomerantseva, Irina; Kulig, Katherine M.; Sundback, Cathryn A.; Vacanti, Joseph P.] Massachusetts Gen Hosp, Dept Surg, Div Pediat Surg, Boston, MA 02114 USA. [Bichara, David A.; Zhao, Xing; Johnson, Matthew; Randolph, Mark A.] Massachusetts Gen Hosp, Plast Surg Res Labs, Boston, MA 02114 USA. [Zhao, Xing] Univ Med Ctr Utrecht, Dept Orthoped, Utrecht, Netherlands. RP Vacanti, JP (reprint author), Dept Pediat Surg, 55 Fruit St,Warren 1151, Boston, MA 02114 USA. FU Armed Forces Institute of Regenerative Medicine [W81XWH-08-2-0034]; US Army Medical Research Acquisition Activity, Fort Detrick, Maryland; US Army Medical Command FX From Massachusetts Eye and Ear Infirmary (Hohman, Lindsay, Cheney, Hadlock); Harvard Medical School (Hohman, Lindsay, Pomerantseva, Bichara, Zhao, Sundback, Randolph, Vacanti, Cheney, Hadlock); and the Department of Surgery, Division of Pediatric Surgery (Pomerantseva, Kulig, Sundback, Vacanti), and the Plastic Surgery Research Laboratories (Bichara, Zhao, Johnson, Randolph), Massachusetts General Hospital; Boston, Massachusetts; and the Department of Orthopedics, University Medical Center Utrecht, Utrecht, the Netherlands (Zhao). This research was sponsored by the Armed Forces Institute of Regenerative Medicine award number W81XWH-08-2-0034. The US Army Medical Research Acquisition Activity, Fort Detrick, Maryland, is the awarding and administering acquisition office. Dr Hohman's effort was also supported by the US Army Medical Command. The content of the manuscript does not necessarily reflect the position or the policy of the Government, and no official endorsement should be inferred. This study was performed in accordance with the PHS Policy on Humane Care and Use of Laboratory Animals, the NIH Guide for the Care and Use of Laboratory Animals, and the Animal Welfare Act (7 U.S.C. et seq.); the animal use protocol was approved by the Institutional Animal Care and Use Committee (IACUC) of Massachusetts General Hospital. CR Berghaus Alexander, 2007, GMS Curr Top Otorhinolaryngol Head Neck Surg, V6, pDoc06 Berghaus A, 2010, ADV OTO-RHINO-LARYNG, V68, P53, DOI 10.1159/000314562 Bichara DA, 2012, TISSUE ENG PART B-RE, V18, P51, DOI [10.1089/ten.TEB.2011.0326, 10.1089/ten.teb.2011.0326] Brent B, 1999, PLAST RECONSTR SURG, V104, P319, DOI 10.1097/00006534-199908000-00001 Firmin F, 1998, SCAND J PLAST RECONS, V32, P35 NAGATA S, 1993, PLAST RECONSTR SURG, V92, P187, DOI 10.1097/00006534-199308000-00001 NEEL HB, 1983, ARCH OTOLARYNGOL, V109, P427 Reinisch JF, 2009, FACIAL PLAST SURG, V25, P181, DOI 10.1055/s-0029-1239448 Romo T, 2008, FACIAL PLAST SURG, V24, P120, DOI 10.1055/s-2008-1037453 Sclafani AP, 1997, ARCH OTOLARYNGOL, V123, P328 Sclafani AP, 1997, PLAST RECONSTR SURG, V99, P41, DOI 10.1097/00006534-199701000-00007 SHANBHAG A, 1990, ANN PLAS SURG, V24, P32, DOI 10.1097/00000637-199001000-00006 Thorne CH, 2001, PLAST RECONSTR SURG, V107, P1241, DOI 10.1097/00006534-200104150-00024 Williams JD, 1997, ARCH OTOLARYNGOL, V123, P578 Zhou LB, 2011, TISSUE ENG PT A, V17, P1573, DOI [10.1089/ten.TEA.2010.0627, 10.1089/ten.tea.2010.0627] NR 15 TC 0 Z9 0 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD FEB PY 2014 VL 123 IS 2 BP 135 EP 140 DI 10.1177/0003489414523710 PG 6 WC Otorhinolaryngology SC Otorhinolaryngology GA AB6TY UT WOS:000331923600008 PM 24574469 ER PT J AU Yi, JS Lim, HW Chang, YS Choi, SH Cho, YS Chung, JW AF Yi, Jong Sook Lim, Hyun Woo Chang, Young Soo Choi, Seung Hyo Cho, Yang-Sun Chung, Jong Woo TI Results of Anterior Facial Nerve Rerouting Procedures for Removing Skull Base Tumors SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE facial function; facial nerve injury; recovery of function; skull base neoplasm; surgical procedure ID JUGULAR FORAMEN TUMORS; SURGERY AB Objectives: The purpose of this study was to estimate the rates of functional recovery of the facial nerve and of total tumor resection in patients who undergo short anterior rerouting and long anterior rerouting of the-facial nerve in removal of skull base tumors. Methods: We retrospectively collected data on 37 patients with skull base tumors who underwent facial nerve rerouting during the procedure for tumor removal. Information on the rerouting technique, the completeness of tumor resection, and changes in facial nerve function were obtained from the medical records. Rerouting techniques were classified as short anterior rerouting or long anterior rerouting. Results: Ten of 16 patients (62.5%) in the group with short anterior rerouting showed postoperative facial palsy, and all completely recovered within 1 year. In the group with long anterior rerouting, 18 of 21 patients (85.7%) showed postoperative facial palsy, and recovery to a preoperative level of facial function was found in 10 patients at 1 year of follow-up. Total tumor resection was possible in 94% and 81% of patients with short rerouting and long rerouting, respectively. The mean operation time was not significantly related to the postoperative recovery of facial function. Conclusions: Short rerouting techniques, when appropriately chosen on the basis of tumor and patient characteristics, offer excellent preservation of facial function and tumor resection, comparable to those of long rerouting techniques. C1 [Yi, Jong Sook; Chung, Jong Woo] Univ Ulsan, Dept Otolaryngol, Asan Med Ctr, Coll Med, Seoul 138736, South Korea. [Chang, Young Soo; Cho, Yang-Sun] Sungkyunkwan Univ, Coll Med, Samsung Med Ctr, Dept Otolaryngol, Seoul, South Korea. [Lim, Hyun Woo] Gangneung Asan Hosp, Dept Otolaryngol, Kangnung, Gangwon, South Korea. [Choi, Seung Hyo] Jeju Natl Univ, Jeju Natl Univ Hosp, Coll Med, Dept Otolaryngol, Cheju, South Korea. RP Chung, JW (reprint author), Univ Ulsan, Dept Otolaryngol, Asan Med Ctr, Coll Med, 388-1 Pungnap Dong, Seoul 138736, South Korea. RI Cho, Yang Sun/F-4611-2014 CR BRACKMANN DE, 1987, OTOLARYNG HEAD NECK, V97, P15 FISCH U, 1984, OTOLARYNG CLIN N AM, V17, P513 Kim CJ, 2001, LARYNGOSCOPE, V111, P2071, DOI 10.1097/00005537-200111000-00038 Moe KS, 1999, SKULL BASE SURG, V9, P185, DOI 10.1055/s-2008-1058145 Mostafa BE, 1998, EUR ARCH OTO-RHINO-L, V255, P115, DOI 10.1007/s004050050024 Parhizkar N, 2005, OTOLARYNG CLIN N AM, V38, P685, DOI 10.1016/j.otc.2005.01.003 Pensak ML, 1997, OTOLARYNG HEAD NECK, V117, P586, DOI 10.1016/S0194-5998(97)70037-8 Russo A, 2003, SKULL BASE-INTERD AP, V13, P123 Sanna M, 1995, Acta Otorrinolaringol Esp, V46, P259 Sanna M, 1998, AM J OTOL, V19, P88 Selesnick SH, 1996, AM J OTOL, V17, P793 So YK, 2007, KOREAN J OTORHINOLAR, V50, P660 VonDoersten PG, 1996, OTOLARYNG HEAD NECK, V115, P82, DOI 10.1016/S0194-5998(96)70141-9 NR 13 TC 0 Z9 0 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD FEB PY 2014 VL 123 IS 2 BP 141 EP 147 DI 10.1177/0003489414523711 PG 7 WC Otorhinolaryngology SC Otorhinolaryngology GA AB6TY UT WOS:000331923600009 PM 24574470 ER PT J AU Wexler, SJ Wernick, B Soliman, AMS AF Wexler, Sonya J. Wernick, Brian Soliman, Ahmed M. S. TI Use of Flexible Esophagoscopy by Otolaryngologists SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE education; endoscopy; esophagoscopy; foreign body ID ESOPHAGUS; IMPACTION AB Objectives: We used questionnaires to determine current practice patterns for esophagoscopy by otolaryngologists in the United States, with attention to foreign body management. Methods: A 10-item questionnaire designed to determine the prevalence of flexible esophagoscopy use among otolaryngologists, with a particular focus on foreign body removal, was created and sent via e-mail to all members of the American Academy of Otolaryngology Head and Neck Surgery. A second, 6-question survey to assess the level of resident training in flexible esophagoscopy was similarly created and sent to all directors of US otolaryngology residency programs. Results: There were a total of 160 respondents to the first survey from all geographic regions, most of whom were in group private practice. Overall, only 21.3% of the respondents were trained to perform flexible esophagoscopy during residency, whereas 43% of those who graduated after 1990 received this training. Most respondents performed flexible esophagoscopy without sedation in the office setting. The most common indications were evaluation of dysphagia, screening for complications of laryngopharyngeal reflux, and panendoscopy for head and neck cancer. Nearly 70% of the respondents were either primarily responsible for foreign body management at their institution or shared this responsibility with a gastroenterology department. Eighty-four percent used the rigid esophagoscope alone for this purpose. More than three quarters of otolaryngology residency programs currently include flexible esophagoscopy in their training, which is performed equally in the operating room and in the office; most favor rigid esophagoscopy for foreign body retrieval but use both techniques. Conclusions: There has been a rapid increase in the use of flexible esophagoscopy by otolaryngologists. The majority of residency programs currently include flexible esophagoscopy in their training. Otolaryngologists play a major role in esophageal foreign body management and primarily use the rigid esophagoscope for this purpose. C1 [Wexler, Sonya J.; Wernick, Brian; Soliman, Ahmed M. S.] Temple Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, Philadelphia, PA 19140 USA. RP Soliman, AMS (reprint author), Temple Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, 3440 N Broad St,Kresge West 312, Philadelphia, PA 19140 USA. CR Aviv JE, 2006, OTOLARYNG HEAD NECK, V135, P616, DOI 10.1016/j.otohns.2006.03.031 Gmeiner D, 2007, SURG ENDOSC, V21, P2026, DOI 10.1007/s00464-007-9252-6 Gustafson LM, 2000, CURR OPIN OTOLARYNGO, V8, P227, DOI 10.1097/00020840-200006000-00018 HIRSCHOWITZ BI, 1963, LANCET, V2, P388 HIRSCHOWITZ BI, 1958, GASTROENTEROLOGY, V35, P50 Katsinelos P, 2006, J CLIN GASTROENTEROL, V40, P784, DOI 10.1097/01.mcg.0000225602.25858.2c Marsh BR, 1996, OTOLARYNG HEAD NECK, V114, P689, DOI 10.1016/S0194-5998(96)70090-6 Schindler R, 1936, AM J DIG DIS, V2, P656 Weissberg D, 2007, ANN THORAC SURG, V84, P1854, DOI 10.1016/j.athoracsur.2007.07.020 NR 9 TC 0 Z9 0 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD JAN PY 2014 VL 123 IS 1 BP 5 EP 10 DI 10.1177/0003489414521142 PG 6 WC Otorhinolaryngology SC Otorhinolaryngology GA AA0YM UT WOS:000330823300001 PM 24574417 ER PT J AU Dorton, LH Lintzenich, CR Evans, AK AF Dorton, LeighAnne H. Lintzenich, Catherine Rees Evans, Adele K. TI Simulation Model for Tracheotomy Education for Primary Health-Care Providers SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE medical education; patient simulation; tracheostomy; tracheotomy ID MECHANICAL VENTILATION; TRACHEOSTOMY; UNIT; DURATION; SAFETY AB Objectives: We performed this study to evaluate the competency of health-care providers managing patients with tracheotomies, and assess the need for, and efficacy of, a multidisciplinary educational program incorporating patient simulation. Methods: The prospective observational study included 87 subjects who manage patients with tracheotomies within a tertiary-care hospital. The subjects completed self-assessment questionnaires and objective multiple-choice tests before and after attending a comprehensive educational course using patient simulation. The outcome measurements included pre-course and post-course questionnaire and test scores, as well as observational data collected during recorded patient simulation sessions. Results: Before the education and simulation, the subjects reported an average comfort level of 3.3 on a 5-point Likert scale across 10 categories in the questionnaire, which improved to 4.4 after the training (p < 0.0001). The subjects' mean scores improved from 56% on the pre-course test to 91% on the post-course test (p < 0.0001). The specific deficiencies observed during patient simulation scenarios included unfamiliarity with different tracheotomy tube types, misunderstanding of speaking valve physiology, and delayed recognition and treatment of a plugged or dislodged tracheotomy tube. Conclusions: There is a significant need for improved tracheotomy education among primary health-care providers. Incorporating patient simulation into a comprehensive tracheotomy educational program was effective in improving provider confidence, increasing provider knowledge, and teaching the skills necessary for managing patients with a tracheotomy. C1 [Dorton, LeighAnne H.; Lintzenich, Catherine Rees; Evans, Adele K.] Wake Forest Univ, Sch Med, Dept Otolaryngol, Winston Salem, NC 27109 USA. RP Evans, AK (reprint author), Med Ctr Blvd, Winston Salem, NC 27157 USA. FU North Carolina's Northwest Area Health Education Center FX We thank North Carolina's Northwest Area Health Education Center for supporting this educational program through its online platform and largely contributing to its success. We also thank the various Wake Forest clinical departments and their members who willingly participated in the study. CR Boynton JH, 2004, CRIT CARE, V8, pR261, DOI 10.1186/cc2885 Casserly P, 2007, BRIT J ANAESTH, V99, P380, DOI 10.1093/bja/aem167 Clec'h C, 2007, CRIT CARE MED, V35, P132, DOI 10.1097/01.CCM.0000251134.96055.A6 Durbin CG, 2010, RESP CARE, V55, P1056 Freeman BD, 2005, CRIT CARE MED, V33, P2513, DOI 10.1097/01.CCM.0000186369.91799.44 Griffiths J, 2005, BRIT MED J, V330, P1243, DOI 10.1136/bmj.38467.485671.E0 HEFFNER JE, 2005, CRIT CARE CLIN, V21, pR9 Heffner JE, 2005, CRIT CARE CLIN, V21, P129, DOI 10.1016/j.ccc.2004.07.002 Lighthall GK, 2003, CRIT CARE MED, V31, P2437, DOI 10.1097/01.CCM.0000089645.94121.42 Martinez GH, 2009, RESP CARE, V54, P1644 Mirski MA, 2012, CRIT CARE MED, V40, P1827, DOI 10.1097/CCM.0b013e31824e16af Nieszkowska A, 2005, CRIT CARE MED, V33, P2527, DOI 10.1097/01.CCM.0000186898.58709.AA Smith-Miller Cherie, 2006, J Nurses Staff Dev, V22, P222, DOI 10.1097/00124645-200609000-00003 NR 13 TC 1 Z9 1 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD JAN PY 2014 VL 123 IS 1 BP 11 EP 18 DI 10.1177/0003489414521144 PG 8 WC Otorhinolaryngology SC Otorhinolaryngology GA AA0YM UT WOS:000330823300002 PM 24574418 ER PT J AU Schramm, JC Sewell, RK Azarow, KS Raynor, SC Abdessalam, SF AF Schramm, Jordan C. Sewell, Ryan K. Azarow, Kenneth S. Raynor, Stephen C. Abdessalam, Shahab F. TI Chronic Cervical Esophageal Foreign Bodies in Children: Surgical Approach After Unsuccessful Endoscopic Management SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE chronic illness; foreign body; infant; ingestion; injury; neck; preschool child ID COIN INGESTION; RESPIRATORY SYMPTOMS; BODY; MEDIASTINITIS; PERFORATION; SECONDARY; STRIDOR; ASTHMA AB Objectives: We reviewed the surgical management of chronic cervical esophageal foreign bodies (CCEFBs) in a pediatric population after failed endoscopic retrieval. Methods: A descriptive analysis via a retrospective chart review of patients with CCEFBs who failed initial endoscopic management was performed between 2008 and 2013. Details were recorded regarding presenting symptoms, time from symptom onset to diagnosis of the CCEFB, surgical approach, and complications. Results: Three patients with CCEFBs unsuccessfully managed with endoscopy were identified. The range of ages at diagnosis was 14 months to 4.5 years. The foreign bodies (FBs) were present for at least 1 month before diagnosis (range, 1 to 10 months). Respiratory symptoms were predominant in all cases. Neck exploration with removal of the FB was performed in each case. Complications included esophageal stricture necessitating serial dilations (patient 1), left true vocal fold paresis that resolved spontaneously (patient 3), and tracheoesophageal fistula with successful endoscopic closure (patient 3). No long-term sequelae were experienced. Conclusions: A high index of suspicion is required to recognize CCEFBs in children with respiratory distress. Although endoscopic management remains the first-line treatment, it may fail or may not be possible because of transmural FB migration. In this setting, neck exploration with FB removal is a safe and effective alternative. C1 [Schramm, Jordan C.; Sewell, Ryan K.] Univ Nebraska, Med Ctr, Coll Med, Dept Otolaryngol Head & Neck Surg, Omaha, NE USA. [Azarow, Kenneth S.; Raynor, Stephen C.; Abdessalam, Shahab F.] Univ Nebraska, Med Ctr, Coll Med, Dept Surg,Div Pediat Surg, Omaha, NE USA. RP Schramm, JC (reprint author), Dept Otolaryngol Head & Neck Surg, 981225 Nebraska Med Ctr, Omaha, NE 68198 USA. CR A-Kader HH, 2010, WORLD J PEDIATR, V6, P301, DOI 10.1007/s12519-010-0231-y BYARD R W, 1990, Pediatric Pathology, V10, P837 Cole S, 2011, ANN OTO RHINOL LARYN, V120, P542 CONNERS GP, 1995, AM J EMERG MED, V13, P638, DOI 10.1016/0735-6757(95)90047-0 DOOLIN EJ, 1993, ANN OTO RHINOL LARYN, V102, P863 Gilchrist BF, 1997, J PEDIATR SURG, V32, P1429, DOI 10.1016/S0022-3468(97)90554-6 Haegen Timothy W, 2003, J Pediatr Surg, V38, pe6, DOI 10.1053/jpsu.2003.50066 HEISS NM, 1995, J FAM PRACTICE, V41, P489 KATZ KR, 1989, AM J DIS CHILD, V143, P961 Kerschner JE, 2001, INT J PEDIATR OTORHI, V59, P89, DOI 10.1016/S0165-5876(01)00454-2 Kim N, 2008, PEDIATR EMERG CARE, V24, P849, DOI 10.1097/PEC.0b013e31818ea100 Miller RS, 2004, INT J PEDIATR OTORHI, V68, P265, DOI 10.1016/j.ijporl.2003.09.021 Mohiuddin S, 2004, SOUTH MED J, V97, P93, DOI 10.1097/01.SMJ.0000091033.99691.0D Naidoo RR, 2004, ANN THORAC SURG, V77, P2218, DOI 10.1016/S0003-4975(03)01255-4 Narasimhappa GM, 2009, INDIAN J PEDIATR, V76, P862, DOI 10.1007/s12098-009-0152-8 NEWMAN DE, 1978, J PEDIATR-US, V92, P60, DOI 10.1016/S0022-3476(78)80071-7 Persaud RAP, 2001, EMERG MED J, V18, P312, DOI 10.1136/emj.18.4.312 RAO CC, 1986, CRIT CARE MED, V14, P988, DOI 10.1097/00003246-198611000-00017 Sapru A, 1998, GASTROINTEST ENDOSC, V48, P218, DOI 10.1016/S0016-5107(98)70172-5 SAVITT DL, 1988, AM J EMERG MED, V6, P378, DOI 10.1016/0735-6757(88)90161-1 SHEPHERD RL, 1977, J THORAC CARDIOV SUR, V74, P261 Stuth EAE, 2001, ANESTHESIOLOGY, V95, P1025, DOI 10.1097/00000542-200110000-00036 TAUSCHER JW, 1978, PEDIATRICS, V61, P657 TUCKER JG, 1994, SOUTHERN MED J, V87, P269, DOI 10.1097/00007611-199402000-00026 WARNER BW, 1992, AM J OTOLARYNG, V13, P181, DOI 10.1016/0196-0709(92)90120-I NR 25 TC 0 Z9 0 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD JAN PY 2014 VL 123 IS 1 BP 19 EP 24 DI 10.1177/0003489414521145 PG 6 WC Otorhinolaryngology SC Otorhinolaryngology GA AA0YM UT WOS:000330823300003 PM 24574419 ER PT J AU Welkoborsky, HJ Hinni, ML Moebius, H Bauer, L Ostertag, H AF Welkoborsky, Hans-J. Hinni, Michael L. Moebius, Hartmut Bauer, Lothar Ostertag, Helmut TI Microscopic Examination of Iatrogenic Subglottic Tracheal Stenosis: Observations That May Elucidate Its Histopathologic Origin SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE etiology; histology; pathogenesis; subglottic tracheal stenosis ID AIRWAY INJURY; GROWTH-FACTOR; RABBIT MODEL; RECONSTRUCTION; LARYNGEAL; MITOMYCIN; EXTENT AB Objectives: The histopathologic origin of iatrogenic subglottic tracheal stenosis (ISTS) remains unclear. The purpose of this study was to use detailed operative microscopy to systematically examine the operative en bloc specimens of patients 2 with ISTS and to observe the histologic and morphological changes in the hopes that these observations will provide insight into the histopathologic origin of these devastating injuries. Methods: The operative specimens of 18 patients who underwent open tracheal or laryngotracheal resection for ISTS were examined. Precise morphological characteristics were investigated for each tissue layer, including the adventitia, the outer surface of the perichondrium, the cartilage, the inner surface of the perichondrium, the submucosa, and the mucosa. Each tissue layer was evaluated independently and in relationship to the other layers. The cartilaginous airway was further evaluated relative to the pars membranacea. Results: The most common morphological finding in the epithelium was squamous metaplasia with occasional intense inflammation visible in the underlying mucosa, including cicatrization. The underlying cartilage demonstrated ossific metaplasia with sequestration in many cases. By far the most pronounced changes were found in the outer perichondrium and overlying adventitia and included diffuse paucicellular or hyperplastic fibrosis with intense hyperplastic scar formation or hyaline cicatrization. In the pars membranacea, severe scar formation and hyperplastic fibrosis were predominant. Ossific metaplasia was particularly severe in the lateral or outer parts of the tracheal ring, particularly in the vicinity of the adventitia and outer perichondrium. These changes were much more pronounced than the relatively minor changes observed in the submucosa and mucosa. Conclusions: The most severe pathologic observations occurred in the lateral tissue layers, ie, the outer perichondrium and adventia. Given that an injury occurs from the tracheal lumen, these tissue layers have the greatest distance from the site of injury. As only minor changes occurred in the inner tissue layers, we hypothesize that these tissues have a greater regenerative Capacity than the outer layers. This study supports the theory that the depth of the airway injury is more critical to the development of ISTS than is the extent or length of the injury. C1 [Welkoborsky, Hans-J.; Moebius, Hartmut; Bauer, Lothar] Acad Hosp, Nordstadt Clin, Dept Otolaryngol Head & Neck Surg, D-30167 Hannover, Germany. [Ostertag, Helmut] Acad Hosp, Nordstadt Clin, Dept Pathol, D-30167 Hannover, Germany. [Hinni, Michael L.] Mayo Clin, Dept Otolaryngol Head & Neck Surg, Scottsdale, AZ USA. RP Welkoborsky, HJ (reprint author), Acad Hosp, Nordstadt Clin, Dept Otolaryngol Head & Neck Surg, Haltenhoffstr 41, D-30167 Hannover, Germany. CR Abbasidezfouli Azizollah, 2009, Interact Cardiovasc Thorac Surg, V9, P446, DOI 10.1510/icvts.2009.202978 Behrend M, 2001, EUR J SURG ONCOL, V27, P581, DOI 10.1053/ejso.2001.1165 Chafin JB, 2007, ARCH OTOLARYNGOL, V133, P358, DOI 10.1001/archotol.133.4.358 Dodge-Khatami A, 2001, J THORAC CARDIOV SUR, V122, P554, DOI 10.1067/mtc.2001.116206 Dohar JE, 1998, INT J PEDIATR OTORHI, V46, P159, DOI 10.1016/S0165-5876(98)00163-3 Inaki N, 2004, J HEART LUNG TRANSPL, V23, P218 Kwon OJ, 2003, EXP LUNG RES, V29, P329, DOI 10.1080/01902140390116517 Ledl C, 2009, ANN OTO RHINOL LARYN, V118, P876 Liberman Moishe, 2009, Semin Thorac Cardiovasc Surg, V21, P278, DOI 10.1053/j.semtcvs.2009.06.004 Li-Korotky HS, 2007, ARCH OTOLARYNGOL, V133, P919, DOI 10.1001/archotol.133.9.919 LIU HP, 1995, PEDIATR PATHOL LAB M, V15, P655 MYER CM, 1994, ANN OTO RHINOL LARYN, V103, P319 Nesek-Adam V, 2010, J ANESTH, V24, P621, DOI 10.1007/s00540-010-0956-8 Otteson TD, 2008, ARCH OTOLARYNGOL, V134, P694, DOI 10.1001/archotol.134.7.694 Rahbar R, 2001, ANN OTO RHINOL LARYN, V110, P1 Rovo L, 2010, OTOLARYNG HEAD NECK, V142, P441, DOI 10.1016/j.otohns.2009.11.010 Sandulache VC, 2009, LARYNGOSCOPE, V119, P1365, DOI 10.1002/lary.20173 Sandidache VC, 2007, ARCH OTOLARYNGOL, V133, P365, DOI 10.1001/archotol.133.4.365 Shuster AM, 1991, VESTN OTORINOLARINGO, V2, P40 Singh T, 2010, ARCH OTOLARYNGOL, V136, P163, DOI 10.1001/archoto.2009.175 Szyfter Witold, 2009, Otolaryngol Pol, V63, P338, DOI 10.1016/S0030-6657(09)70137-4 Tiozzo C, 2009, PEDIATR RES, V66, P386, DOI 10.1203/PDR.0b013e3181b45580 Wain John C Jr, 2009, Semin Thorac Cardiovasc Surg, V21, P284, DOI 10.1053/j.semtcvs.2009.08.001 Walner DL, 2000, OTOLARYNG HEAD NECK, V122, P363, DOI 10.1016/S0194-5998(00)70049-0 Ward RF, 1998, INT J PEDIATR OTORHI, V44, P221, DOI 10.1016/S0165-5876(98)00061-5 Wong Jyi Lin, 2010, Cases J, V3, P2, DOI 10.1186/1757-1626-3-2 NR 26 TC 1 Z9 1 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD JAN PY 2014 VL 123 IS 1 BP 25 EP 31 DI 10.1177/0003489414521382 PG 7 WC Otorhinolaryngology SC Otorhinolaryngology GA AA0YM UT WOS:000330823300004 PM 24574420 ER PT J AU Patel, SH Munson, ND Grant, DG Buskirk, SJ Hinni, ML Perry, WC Foote, RL McNeil, RB Halyard, MY AF Patel, Samir H. Munson, Nathan D. Grant, David G. Buskirk, Steven J. Hinni, Michael L. Perry, William C. Foote, Robert L. McNeil, Rebecca B. Halyard, Michele Y. TI Relapse Patterns After Transoral Laser Microsurgery and Postoperative Irradiation for Squamous Cell Carcinomas of the Tonsil and Tongue Base SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE oropharyngeal cancer; radiation; radiation therapy; transoral laser microsurgery ID OROPHARYNGEAL CANCER; RADIATION-THERAPY; NECK-CANCER; ADJUVANT RADIOTHERAPY; HUMAN-PAPILLOMAVIRUS; ADVANCED HEAD; SURGERY; LARYNX; CHEMOTHERAPY; FEATURES AB Objectives: We evaluated relapse patterns after transoral laser microsurgery (TLM) in squamous cell carcinoma (SCC) of the tonsil and tongue base and evaluated the indications for adjuvant irradiation. Methods: Between December 1, 1996, and December 31, 2005, 79 patients with previously untreated SCC of the tonsil or tongue base underwent TLM with or without neck dissection. Thirty-eight patients (48%) underwent postoperative irradiation (median, 62 Gy) to the primary site and the neck. Analysis of relapse patterns was performed on the basis of adverse risk factors and the presence or absence of adjuvant irradiation. Results: The median follow-up for living patients was 47 months (range, 10 to 107 months), and patients were monitored for at least 2 years or until recurrence or death. Local, regional, and distant treatment failures numbered 4, 6, and 4 for surgery alone (n = 41) and 0, 2, and 6 for adjuvant irradiation (n = 38), respectively. Patients with high-risk features (extracapsular extension or at least 2 adverse factors) had locoregional control rates at 2 or more years of 66% and 94% for TLM alone and TLM plus adjuvant irradiation, respectively. Conclusions: Adjuvant irradiation after TLM resection of oropharyngeal SCC with intermediate- or high-risk features improves locoregional control compared with TLM alone. C1 [Patel, Samir H.; Halyard, Michele Y.] Mayo Clin, Dept Radiat Oncol, Scottsdale, AZ 85259 USA. [Hinni, Michael L.; Perry, William C.] Mayo Clin, Dept Otolaryngol Head & Neck Surg, Scottsdale, AZ 85259 USA. [Hinni, Michael L.; Perry, William C.] Mayo Clin, Dept Audiol, Scottsdale, AZ 85259 USA. [Munson, Nathan D.; Buskirk, Steven J.] Mayo Clin, Dept Radiat Oncol, Jacksonville, FL USA. [Grant, David G.] Mayo Clin, Dept Otolaryngol Head & Neck Surg, Jacksonville, FL USA. [Grant, David G.] Mayo Clin, Dept Audiol, Jacksonville, FL USA. [McNeil, Rebecca B.] Mayo Clin, Biostat Unit, Jacksonville, FL USA. [Foote, Robert L.] Mayo Clin, Dept Radiat Oncol, Rochester, MN USA. RP Patel, SH (reprint author), Mayo Clin, Dept Radiat Oncol, 13400 E Shea Blvd, Scottsdale, AZ 85259 USA. EM patel.samir@mayo.edu CR AMBROSCH P, 1994, LARYNGO RHINO OTOL, V73, P78, DOI 10.1055/s-2007-997084 AMDUR RJ, 1989, INT J RADIAT ONCOL, V16, P25 Ang KK, 2010, NEW ENGL J MED, V363, P24, DOI 10.1056/NEJMoa0912217 Ang KK, 2001, INT J RADIAT ONCOL, V51, P571, DOI 10.1016/S0360-3016(01)01690-X Bernier J, 2004, NEW ENGL J MED, V350, P1945, DOI 10.1056/NEJMoa032641 Bhattacharyya N, 2001, ARCH OTOLARYNGOL, V127, P127 Cengiz M, 2006, INT J RADIAT ONCOL, V65, P955, DOI 10.1016/j.ijrobp.2006.02.032 Cooper JS, 2004, NEW ENGL J MED, V350, P1937, DOI 10.1056/NEJMoa032646 Dauer E, 2006, OTOLARYNG HEAD NECK, V134, P830, DOI 10.1016/j.otohns.2005.12.030 FOOTE RL, 1994, CANCER, V73, P2638, DOI 10.1002/1097-0142(19940515)73:10<2638::AID-CNCR2820731028>3.0.CO;2-H FOOTE RL, 1993, HEAD NECK-J SCI SPEC, V15, P300, DOI 10.1002/hed.2880150406 Grant DG, 2006, LARYNGOSCOPE, V116, P2150, DOI 10.1097/01.mlg.0000244159.64179.f0 Grant DG, 2009, ARCH OTOLARYNGOL, V135, P1225, DOI 10.1001/archoto.2009.185 Grant DG, 2007, OTOLARYNG HEAD NECK, V136, P900, DOI 10.1016/j.otohns.2006.12.015 Grant DG, 2006, LARYNGOSCOPE, V116, P2156, DOI 10.1097/01.mlg.0000244176.74302.e6 Grant DG, 2007, OTOLARYNG HEAD NECK, V137, P482, DOI 10.1016/j.otohns.2007.05.064 Haughey BH, 2011, HEAD NECK-J SCI SPEC, V33, P1683, DOI 10.1002/hed.21669 Hinni ML, 2007, ARCH OTOLARYNGOL, V133, P1198, DOI 10.1001/archotol.133.12.1198 Holsinger FC, 2007, INT J RADIAT ONCOL, V69, pS129, DOI 10.1016/j.ijrobp.2007.05.044 KAPLAN EL, 1958, J AM STAT ASSOC, V53, P457, DOI 10.2307/2281868 LARAMORE GE, 1993, INT J RADIAT ONCOL, V27, P1011 National Comprehensive Cancer Network, NCCN GUID CLIN RES V Parsons JT, 2002, CANCER, V94, P2967, DOI 10.1002/cncr.10567 Pearson BW, 2003, LARYNGOSCOPE, V113, P1104, DOI 10.1097/00005537-200307000-00002 Pradier O, 2005, INT J RADIAT ONCOL, V63, P1368, DOI 10.1016/j.ijrobp.2005.05.027 Rich JT, 2009, LARYNGOSCOPE, V119, P1709, DOI 10.1002/lary.20552 Sinha P, 2012, CANCER-AM CANCER SOC, V118, P3519, DOI 10.1002/cncr.26671 Steiner W, 1988, Adv Otorhinolaryngol, V39, P135 Steyerberg EW, 2001, MED DECIS MAKING, V21, P45 STRONG MS, 1972, ANN OTO RHINOL LARYN, V81, P791 NR 30 TC 0 Z9 0 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD JAN PY 2014 VL 123 IS 1 BP 32 EP 39 DI 10.1177/0003489414521383 PG 8 WC Otorhinolaryngology SC Otorhinolaryngology GA AA0YM UT WOS:000330823300005 PM 24574421 ER PT J AU Lin, CC Wang, YP Lee, KS Liaw, SF Chiu, CH AF Lin, Ching-Chi Wang, Ying-Piao Lee, Kuo-Sheng Liaw, Shwu-Fang Chiu, Chung-Hsin TI Effect of Uvulopalatopharyngoplasty on Leptin and Endothelial Function in Sleep Apnea SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE endothelial function; leptin; nitric oxide derivative; obstructive sleep apnea syndrome; uvulopalatopharyngoplasty ID POSITIVE AIRWAY PRESSURE; METABOLIC SYNDROME; NITRIC-OXIDE; INSULIN-RESISTANCE; OXIDATIVE STRESS; ADIPOCYTOKINES; ATHEROSCLEROSIS; ASSOCIATION; DYSFUNCTION; DISEASE AB Objectives: This study evaluated the effects of uvulopalatopharyngoplasty (UPPP) on serum leptin levels and endothelial function in patients with obstructive sleep apnea syndrome (OSAS). Methods: Fifteen healthy subjects and 35 patients with moderate to severe OSAS who desired UPPP were prospectively enrolled. The serum levels of leptin and nitric oxide derivative (NOx) from their peripheral blood samples were measured by enzyme-linked immunosorbent assay. All subjects participated in sleep studies, which were repeated 3 months after UPPP in the patients with OSAS. Results: Before UPPP, the patients with OSAS had a higher serum level of leptin and a lower NOx level than did the control subjects. The serum leptin levels in the 17 of the 35 patients with OSAS who were surgical responders decreased from 24.2 +/- 6.1 ng/mL before operation to 15.9 +/- 6.0 ng/mL after operation. The serum NOx levels in these 17 patients increased from 18.5 +/- 7.5 mu mol/L before operation to 27.3 +/- 8.2 mu mol/L after operation. In the 18 patients who were unresponsive to surgery, the serum leptin and NOx levels remained impaired after the UPPP. Conclusions: Successful treatment of OSAS with UPPP leads to the normalization of serum leptin and NOx levels. C1 [Lin, Ching-Chi] Mackay Mem Hosp, Dept Internal Med, Chest Div, Taipei, Taiwan. [Lin, Ching-Chi; Liaw, Shwu-Fang] Mackay Mem Hosp, Dept Med Res, Taipei, Taiwan. [Wang, Ying-Piao; Lee, Kuo-Sheng] Mackay Mem Hosp, Dept Otolaryngol, Taipei, Taiwan. [Lin, Ching-Chi; Chiu, Chung-Hsin] Mackay Mem Hosp, Sleep Ctr, Taipei, Taiwan. [Lin, Ching-Chi] Mackay Med Nursing & Management Coll, Dept Nursing, Taipei, Taiwan. RP Lin, CC (reprint author), Mackay Mem Hosp, Dept Internal Med, Chest Div, 92 Sect 2,Chung Shan North Rd, Taipei, Taiwan. CR Beltowski J, 2006, ATHEROSCLEROSIS, V189, P47, DOI 10.1016/j.atherosclerosis.2006.03.003 BUSSE R, 1995, ANN MED, V27, P331, DOI 10.3109/07853899509002586 Cheng KH, 2008, INT J OBESITY, V32, P268, DOI 10.1038/sj.ijo.0803726 Cirillo P, 2010, THROMB HAEMOSTASIS, V103, P1065, DOI 10.1160/TH09-06-0392 Correia MLG, 2006, DIABETES OBES METAB, V8, P603, DOI 10.1111/j.1463-1326.2005.00562.x Cuhadaroglu C, 2009, LUNG, V187, P75, DOI 10.1007/s00408-008-9131-5 Feng J, 2009, SLEEP BREATH, V13, P277, DOI 10.1007/s11325-009-0246-6 Grebe M, 2006, AM J RESP CRIT CARE, V173, P897, DOI 10.1164/rccm.200508-1223OC Iber C, 2007, AASM MANUAL SCORING Ip MSM, 2002, AM J RESP CRIT CARE, V165, P670, DOI 10.1164/rccm.2103001 Kalra SP, 2008, PEPTIDES, V29, P127, DOI 10.1016/j.peptides.2007.10.017 KEENAN SP, 1994, CHEST, V105, P155, DOI 10.1378/chest.105.1.155 Lavie L, 2003, SLEEP MED REV, V7, P35, DOI 10.1053/smrv.2002.0261 Matarese G, 2007, CURR PHARM DESIGN, V13, P3676, DOI 10.2174/138161207783018635 Nakra N, 2008, PEDIATRICS, V122, pE634, DOI 10.1542/peds.2008-0154 Ohike Y, 2005, CIRC J, V69, P221, DOI 10.1253/circj.69.221 Oyama J, 2012, CLIN CARDIOL, V35, P231, DOI 10.1002/clc.21010 Ozturk L, 2003, ARCH OTOLARYNGOL, V129, P538, DOI 10.1001/archotol.129.5.538 Pankow W, 2000, NEW ENGL J MED, V343, P966 Peker Y, 2002, AM J RESP CRIT CARE, V166, P159, DOI 10.1164/rccm.2105124 Phillips BG, 2000, AM J PHYSIOL-HEART C, V279, pH234 Piatti P, 2003, CIRCULATION, V108, P2074, DOI 10.1161/01.CIR.0000095272.67948.17 Sher AE, 1996, SLEEP, V19, P156 Tatsumi K, 2005, CHEST, V127, P716, DOI 10.1378/chest.127.3.716 Tokuda F, 2008, INTERNAL MED, V47, P1843, DOI 10.2169/internalmedicine.47.1035 Yee BJ, 2006, RESPIRATION, V73, P209, DOI 10.1159/000088358 Zirlik S, 2011, MED SCI MONITOR, V17, pCR159 NR 27 TC 0 Z9 0 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD JAN PY 2014 VL 123 IS 1 BP 40 EP 46 DI 10.1177/0003489414521385 PG 7 WC Otorhinolaryngology SC Otorhinolaryngology GA AA0YM UT WOS:000330823300006 PM 24574422 ER PT J AU Heo, KW Kang, MK Park, JY AF Heo, Kyung Wook Kang, Myung Koo Park, Jae Yeong TI Alternative to Canal Wall-Down Mastoidectomy for Sclerotic Mastoid Cavities: Epitympanoplasty With Mastoid Obliteration SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE ear disease; mastoid cavity; surgery ID LONG-TERM; PEDIATRIC CHOLESTEATOMA; OTITIS-MEDIA; FOLLOW-UP; TYMPANOPLASTY; RECONSTRUCTION; CHILDREN; SURGERY; BONE AB Objectives: Surgical procedures for chronic ear disease can be grossly divided into two tympanoplasty procedures: canal wall up and canal wall down (CWD) mastoidectomies. The choice depends on the surgeon's preference. Epitympanoplasty with mastoid obliteration (EMO) has shown postoperative results similar to those of CWD mastoidectomy with long-term follow-up. In this study, we compared the outcomes of EMO and CWD mastoidectomy in preoperatively sclerotic mastoid cavities with cholesteatoma, chronic otitis media with poor eustachian tube function, or adhesive otitis media. The operations were performed by the same surgeons in order to eliminate any effect of surgeon preference on the surgical outcomes. Methods: We reviewed the medical records of patients who underwent tympanoplasty with EMO (EMO group) or CWD mastoidectomy (CWD group) and followed them for more than 28 months. The postoperative outcomes were analyzed and compared. Results: The EMO and CWD groups comprised 132 and 110 ears, respectively. In both groups, the air-bone gaps were significantly reduced after operation. The relapse rates of the groups were similar. Cavity problems were the most common complication in the CWD group. The overall complication rate in the EMO group was significantly lower than that in the CWD group (p = 0.044). Conclusions: Epitympanoplasty with mastoid obliteration can be considered an alternative procedure to CWD mastoidectomy in patients with preoperatively sclerotic mastoid cavities. It gives similar surgical results and has fewer complications. C1 [Heo, Kyung Wook] Inje Univ, Coll Med, Busan Paik Hosp, Dept Otorhinolaryngol Head & Neck Surg, Pusan, South Korea. [Kang, Myung Koo] Dong A Univ, Coll Med, Dept Otorhinolaryngol Head & Neck Surg, Pusan 602715, South Korea. [Park, Jae Yeong] Med Ear Nose Throat Clin, Pusan, South Korea. RP Kang, MK (reprint author), Dong A Univ, Coll Med, Dept Otorhinolaryngol Head & Neck Surg, Pusan 602715, South Korea. FU Inje University research grant FX This work was supported by a 2012 Inje University research grant. CR Alicandri-Ciufelli M, 2012, MED HYPOTHESES, V78, P364, DOI 10.1016/j.mehy.2011.12.006 [Anonymous], 1995, OTOLARYNGOL HEAD NEC, V113, P186 Dodson EE, 1998, LARYNGOSCOPE, V108, P977, DOI 10.1097/00005537-199807000-00005 Kang MK, 2009, OTOLARYNG HEAD NECK, V140, P687, DOI 10.1016/j.otohns.2008.11.027 Kim JH, 2009, CLIN EXP OTORHINOLAR, V2, P39, DOI 10.3342/ceo.2009.2.1.39 KINNEY SE, 1988, LARYNGOSCOPE, V98, P1190 Lee WS, 2005, OTOL NEUROTOL, V26, P1107, DOI 10.1097/01.mao.0000184603.32796.6c Lee WS, 2009, ACTA OTO-LARYNGOL, V129, P955, DOI 10.1080/00016480802510178 Merchant SN, 1997, LARYNGOSCOPE, V107, P872, DOI 10.1097/00005537-199707000-00007 MEUSER W, 1985, AM J OTOL, V6, P323 Mosher H. P., 1911, LARYNGOSCOPE, V21, P1158 Nyrop M, 1997, J LARYNGOL OTOL, V111, P521 Park JS, 2011, J INT ADV OTOL, V7, P305 Roberson JB, 2003, OTOL NEUROTOL, V24, P132 Shohet JA, 2002, OTOLARYNG CLIN N AM, V35, P841, DOI 10.1016/S0030-6665(02)00052-X Toros SZ, 2010, ACTA OTO-LARYNGOL, V130, P909, DOI 10.3109/00016480903559731 Valtonen HJ, 2005, LARYNGOSCOPE, V115, P268, DOI 10.1097/01.mlg.0000154731.08410.b8 VARTIAINEN E, 1987, CLIN OTOLARYNGOL, V12, P327, DOI 10.1111/j.1365-2273.1987.tb00211.x Vercruysse JP, 2008, OTOL NEUROTOL, V29, P953, DOI 10.1097/MAO.0b013e318184f4d6 WULLSTEIN H, 1960, ARCHIV OTOLARYNGOL, V71, P408 NR 20 TC 1 Z9 1 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD JAN PY 2014 VL 123 IS 1 BP 47 EP 52 DI 10.1177/0003489414521387 PG 6 WC Otorhinolaryngology SC Otorhinolaryngology GA AA0YM UT WOS:000330823300007 PM 24574423 ER PT J AU Loyo, M Espinoza, S Giraud, P Laccourreye, O AF Loyo, Myriam Espinoza, Sophie Giraud, Philippe Laccourreye, Ollivier TI Early and Severe Dyspnea After Supracricoid Partial Laryngectomy SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE cancer; larynx; partial laryngectomy ID CRICOHYOIDOPEXY; OUTCOMES AB We present the case of a not-yet-reported complication that occurred during the immediate postoperative period after supracricoid partial laryngectomy. We include a review of the literature on complications following this procedure, emphasizing technical considerations that are critical during this surgery. Clinical, diagnostic, and operative findings are presented, as is a differential diagnosis for early and severe postoperative dyspnea following supracricoid laryngectomy. C1 [Loyo, Myriam; Laccourreye, Ollivier] Univ Paris 05, AP HP, Sorbonne Paris Cite, HEGP,Dept Otorhinolaryngol Head & Neck Surg, Paris, France. [Espinoza, Sophie] Univ Paris 05, AP HP, Sorbonne Paris Cite, HEGP,Dept Radiol, Paris, France. [Giraud, Philippe] Univ Paris 05, AP HP, Sorbonne Paris Cite, HEGP,Dept Radiat Therapy, Paris, France. RP Laccourreye, O (reprint author), HEGP, Dept Otorhinolaryngol Head & Neck Surg, 20-40 Rue Leblanc, F-75015 Paris, France. CR Benito J, 2011, HEAD NECK-J SCI SPEC, V33, P679, DOI 10.1002/hed.21521 Decotte A, 2009, Rev Laryngol Otol Rhinol (Bord), V130, P225 Holsinger FC, 2005, J AM COLL SURGEONS, V201, P809, DOI 10.1016/j.jamcollsurg.2005.06.260 LACCOURREYE H, 1990, LARYNGOSCOPE, V100, P735 LACCOURREYE H, 1990, Annals of Otology Rhinology and Laryngology, V99, P421 Laccourreye O, 1997, ANN OTO RHINOL LARYN, V106, P159 Levitan N, 1999, MEDICINE, V78, P285, DOI 10.1097/00005792-199909000-00001 Naudo P, 1998, OTOLARYNG HEAD NECK, V118, P124, DOI 10.1016/S0194-5998(98)70388-2 Naudo P, 1997, ANN OTO RHINOL LARYN, V106, P291 Pontes P, 2001, ANN OTO RHINOL LARYN, V110, P765 Rivera-Serrano Carlos M, 2011, Ear Nose Throat J, V90, pE25 Rombaux P, 2000, EUR ARCH OTO-RHINO-L, V257, P502, DOI 10.1007/s004050000267 Sobin LH, 2009, TNM CLASSIFICATION M, V7th Thomas L, 2012, CANCER TREAT REV, V38, P203, DOI 10.1016/j.ctrv.2011.05.010 NR 14 TC 0 Z9 0 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD JAN PY 2014 VL 123 IS 1 BP 53 EP 57 DI 10.1177/0003489414521386 PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA AA0YM UT WOS:000330823300008 PM 24574424 ER PT J AU Bacciu, A Di Lella, F Ventura, E Pasanisi, E Russo, A Sanna, M AF Bacciu, Andrea Di Lella, Filippo Ventura, Elisa Pasanisi, Enrico Russo, Alessandra Sanna, Mario TI Lipomas of the Internal Auditory Canal and Cerebellopontine Angle SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE cerebellopontine angle; internal auditory canal; lipoma AB Objectives: Lipomas of the internal auditory canal (IAC) and cerebellopontine angle (CPA) are exceedingly rare lesions. The purpose of this report was to describe our experience with lipomas of the IAC and CPA and perform a review of the literature. Methods: We report 8 cases of lipomas involving the IAC and/or the CPA that were managed at Gruppo Otologico between April 1987 and October 2012. Results: Four cases of entirely intracanalicular lipomas were radiologically misinterpreted as vestibular schwannomas and underwent tumor removal by a translabyrinthine approach. Two of these patients experienced postoperative facial nerve palsy. Lipomas were suspected in 4 patients on the basis of imaging findings and were managed conservatively. Of these 4 cases, 3 did not show any growth after an average period of 28 months, and 1 case demonstrated tumor growth on follow-up imaging. Conclusions: Neuroirnaging represents an extremely important tool for this diagnosis. Attempts to achieve complete resection may result in severe neurologic sequelae, especially in large lesions. Observation with repeated imaging in order to detect growth of the lesion is usually recommended. Debulking of the tumor, mainly aimed at brain stem and cranial nerve decompression, should be considered in cases of disabling and uncontrolled neurologic symptoms and signs. C1 [Bacciu, Andrea; Pasanisi, Enrico] Univ Hosp Parma, Head & Neck Dept, I-43100 Parma, Italy. [Ventura, Elisa] Univ Hosp Parma, Dept Neuroradiol, I-43100 Parma, Italy. [Di Lella, Filippo; Russo, Alessandra; Sanna, Mario] Grp Otol Piacenza Rome, Piacenza, Italy. [Di Lella, Filippo; Russo, Alessandra; Sanna, Mario] Univ G dAnnunzio, Dept Oral & Nanobiotechnol Sci, Chieti, Italy. RP Bacciu, A (reprint author), Univ Hosp Parma, Head & Neck Dept, Via Gramsci 14, I-43100 Parma, Italy. CR Bigelow DC, 1998, LARYNGOSCOPE, V108, P1459, DOI 10.1097/00005537-199810000-00008 CHRISTENSEN WN, 1986, HUM PATHOL, V17, P739, DOI 10.1016/S0046-8177(86)80184-8 Dahlen RT, 2002, AM J NEURORADIOL, V23, P1413 Dazert S, 2005, EUR ARCH OTO-RHINO-L, V262, P550, DOI 10.1007/s00405-003-0734-4 Greinwald JH, 1997, LARYNGOSCOPE, V107, P364, DOI 10.1097/00005537-199703000-00016 Gurgel RK, 2012, OTOLARYNG HEAD NECK, V147, P803, DOI 10.1177/0194599812458401 HOUSE JW, 1985, OTOLARYNG HEAD NECK, V93, P146 Klob J., 1859, Z GESELLSCH ARZTE WI, V15, P673 Mukherjee P, 2011, OTOL NEUROTOL, V32, P670, DOI 10.1097/MAO.0b013e31821179e0 OKEEFFE LJ, 1993, J LARYNGOL OTOL, V107, P553, DOI 10.1017/S0022215100123680 Rodriguez Prado N, 2004, ACTA OTORRINOLARINGO, V55, P126 SAUNDERS JE, 1991, LARYNGOSCOPE, V101, P1031 Tankere F, 2002, NEUROSURGERY, V50, P626, DOI 10.1097/00006123-200203000-00037 Trawit CL, 1990, AM J ROENTGENOL, V155, P855 Ventura E, 2012, AURIS NASUS LARYNX, V39, P103, DOI 10.1016/j.anl.2011.01.021 NR 15 TC 2 Z9 2 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD JAN PY 2014 VL 123 IS 1 BP 58 EP 64 DI 10.1177/0003489414521384 PG 7 WC Otorhinolaryngology SC Otorhinolaryngology GA AA0YM UT WOS:000330823300009 PM 24574425 ER PT J AU Haft, S Lee, JY Ghosh, A Philiponis, G Malaisrie, N Leahy, KP Singhal, S Cohen, NA Mirza, N AF Haft, Sunny Lee, Jennifer Y. Ghosh, Ankona Philiponis, Genevieve Malaisrie, Nora Leahy, Kevin P. Singhal, Sunil Cohen, Noam A. Mirza, Natasha TI Inflammatory Protein Expression in Human Subglottic Stenosis Tissue Mirrors That in a Murine Model SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE human study; laryngotracheal stenosis; subglottic stenosis; translational study; wound healing ID AIRWAY STENOSIS; MECHANISMS; DISEASE; REPAIR AB Objectives: We undertook to describe the genetic and protein composition of subglottic stenosis (SGS) by measuring an array of protein expression and messenger RNA levels within human SGS tissue. We also sought to compare this human array to cytokine expression from a murine model of SGS in order to confirm the effective translational nature of our animal model. Methods: Human granulation tissue from 10 patients with early symptomatic SOS was compared to control bronchus. The expression levels of 24 different cytokines were measured by a Luminex protein assay and real-time polymerase chain reaction. Results: The protein expression in human SGS mirrors that seen in murine SGS. Transforming growth factor 131, interleukin 1 beta, and matrix metalloproteinase 9 were markedly elevated in both human and mouse SOS tissues. The protein array showed a statistically significant elevation in the proinflammatory cytokines tumor necrosis factor a, interleukin 1, granulocyte macrophage colony-stimulating factor, and interferon gamma. Conclusions: This is the first study, to our knowledge, to measure an array of protein expression within human SOS tissue. The expression profile suggests that symptomatic tracheal granulation tissue is mostly within the early inflammatory phase of wound healing and has only begun fibrotic and angiogenic remodeling. This study validates our murine model of SGS, and also helps to define the exact pathways of tissue injury, in the hope of leading to new treatments for this difficult condition. C1 [Haft, Sunny; Lee, Jennifer Y.; Ghosh, Ankona; Philiponis, Genevieve; Malaisrie, Nora; Leahy, Kevin P.; Singhal, Sunil; Cohen, Noam A.; Mirza, Natasha] Univ Penn, Dept Otorhinolaryngol Head & Neck Surg, Philadelphia, PA 19104 USA. RP Haft, S (reprint author), Univ Penn, Dept Otorhinolaryngol Head & Neck Surg, 3400 Spruce St, Philadelphia, PA 19104 USA. CR Branski RC, 2005, ANN OTO RHINOL LARYN, V114, P19 Branski RC, 2004, ANN OTO RHINOL LARYN, V113, P23 Clark R.F., 1996, MOL CELLULAR BIOL WO Crosby LM, 2010, AM J PHYSIOL-LUNG C, V298, pL715, DOI 10.1152/ajplung.00361.2009 Dohar JE, 1998, INT J PEDIATR OTORHI, V46, P159, DOI 10.1016/S0165-5876(98)00163-3 Gabay C, 2013, LANCET, V381, P1541, DOI 10.1016/S0140-6736(13)60250-0 Ghosh A, 2013, OTOLARYNG HEAD NECK, V148, P284, DOI 10.1177/0194599812466533 Ghosh A, 2011, OTOLARYNG HEAD NECK, V144, P927, DOI 10.1177/0194599810397750 Hasleton P., 1996, SPENCERS PATHOLOGY L, P6 Hirshoren N, 2009, HEAD NECK-J SCI SPEC, V31, P111, DOI 10.1002/hed.20925 Karagiannidis C, 2006, CHEST, V129, P1298, DOI 10.1378/chest.129.5.1298 Kelly NA, 2012, LARYNGOSCOPE, V122, P2574, DOI 10.1002/lary.23515 Liechty KW, 2000, CYTOKINE, V12, P671, DOI 10.1006/cyto.1999.0598 Liechty KW, 1998, J SURG RES, V77, P80, DOI 10.1006/jsre.1998.5345 LIU HP, 1995, PEDIATR PATHOL LAB M, V15, P655 Mehrad B, 2009, INT J BIOCHEM CELL B, V41, P1708, DOI 10.1016/j.biocel.2009.02.020 Puyo CA, 2012, ARCH OTOLARYNGOL, V138, P854, DOI 10.1001/archoto.2012.1746 Reimund JM, 1996, J CLIN IMMUNOL, V16, P144, DOI 10.1007/BF01540912 Richter GT, 2009, ARCH OTOLARYNGOL, V135, P45, DOI 10.1001/archoto.2008.516 Scioscia KA, 1996, ANN OTO RHINOL LARYN, V105, P936 Senchak AJ, 2007, COMPARATIVE MED, V57, P594 Simpson CB, 2008, LARYNGOSCOPE, V118, P546, DOI 10.1097/MLG.0b013e31815daf6e Singer AJ, 1999, NEW ENGL J MED, V341, P738 NR 23 TC 0 Z9 0 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD JAN PY 2014 VL 123 IS 1 BP 65 EP 70 DI 10.1177/0003489414521146 PG 6 WC Otorhinolaryngology SC Otorhinolaryngology GA AA0YM UT WOS:000330823300010 PM 24574426 ER PT J AU Durkes, A Sivasankar, MP AF Durkes, Abigail Sivasankar, M. Preeti TI Bicarbonate Availability for Vocal Fold Epithelial Defense to Acidic Challenge SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE bicarbonate; ion transport; laryngopharyngeal reflux; vocal fold ID LARYNGOPHARYNGEAL REFLUX; CARBONIC-ANHYDRASE; SUBMUCOSAL GLANDS; DISEASE; PHYSIOLOGY; TRANSPORT; PEPSIN; CELLS; PATHWAYS; SURFACE AB Objectives: Bicarbonate is critical for acid-base tissue homeostasis. In this study we investigated the role of bicarbonate ion transport in vocal fold epithelial defense to acid challenges. Acidic insults to the larynx are common in gastric reflux, carcinogenesis and metastasis, and acute inflammation. Methods: Ion transport was measured in viable porcine vocal fold epithelium. First, 18 vocal folds were exposed to either the carbonic anhydrase antagonist acetazolamide or to vehicle. Second, 32 vocal folds were exposed to either a control buffer or a bicarbonate-free buffer on their luminal or basolateral surface or both. Third, 32 vocal folds were challenged with acid in the presence of bicarbonate-free or control buffer. Results: The vocal fold transepithelial resistance was greater than 300 Omega*cm(2), suggesting robust barrier integrity. Ion transport did not change after exposure to acetazolamide (p > 0.05). Exposure to bicarbonate-free buffer did not compromise vocal fold ion transport (p > 0.05). Ion transport increased after acid challenge. This increase approached statistical significance and was the greatest for the control buffer and for the bicarbonate-free buffer applied to the basolateral surface. Conclusions: Bicarbonate secretion may contribute to vocal fold defense against acid challenge. Our data offer a potential novel role for bicarbonate as a therapeutic agent to reduce pH abnormalities in the larynx and prevent associated pathological changes. C1 [Durkes, Abigail] Purdue Univ, Coll Vet Med, Dept Comparat Pathobiol, W Lafayette, IN 47907 USA. [Sivasankar, M. Preeti] Purdue Univ, Dept Speech Language & Hearing Sci, W Lafayette, IN 47907 USA. RP Sivasankar, MP (reprint author), Purdue Univ, W Lafayette, IN 47907 USA. FU NIH [R01DC011759] FX This research was funded by NIH grant R01DC011759. This study was performed in accordance with the PHS Policy on Humane Care and Use of Laboratory Animals, the NIH Guide for the Care and Use of Laboratory Animals, and the Animal Welfare Act (7 U.S.C. et seq.); the animal use protocol was approved by the Institutional Animal Care and Use Committee (IACUC) of Purdue University. CR Abdulnour-Nakhoul S, 2000, AM J PHYSIOL-GASTR L, V278, pG113 Akiba Y, 1999, AM J PHYSIOL-GASTR L, V277, pG268 Chegwidden WR, 2000, EXS, V90, P14 CHRISTIE KN, 1995, HISTOCHEM J, V27, P587 Cordat E, 2009, BIOCHEM J, V417, P423, DOI 10.1042/BJ20081634 Davids MR, 2002, CAN J PHYSIOL PHARM, V80, P835, DOI 10.1139/Y02-114 DUBOS R J, 1955, Lancet, V269, P1 Erickson E, 2010, LARYNGOSCOPE, V120, P1569, DOI 10.1002/lary.20983 Erickson-Levendoski E, 2011, OTOLARYNGOL HEAD NEC Fisher KV, 2001, J APPL PHYSIOL, V91, P1401 Gill GA, 2005, ANN OTO RHINOL LARYN, V114, P913 Gray SD, 2000, OTOLARYNG CLIN N AM, V33, P679, DOI 10.1016/S0030-6665(05)70237-1 Hirschhaeuser F, 2011, CANCER RES, V71, P6921, DOI 10.1158/0008-5472.CAN-11-1457 Johnston N, 2006, ANN OTO RHINOL LARYN, V115, P47 Johnston N, 2003, ANN OTO RHINOL LARYN, V112, P481 KOUFMAN JA, 1991, LARYNGOSCOPE, V101, P1 Krouse ME, 2004, AM J PHYSIOL-LUNG C, V287, pL1274, DOI 10.1152/ajplung.00036.2004 Leydon C, 2009, J VOICE, V23, P658, DOI 10.1016/j.jvoice.2008.03.010 Lin BR, 2008, J PHYSIOL PHARMACOL, V59, P525 Phillips JE, 1999, BIOPHYS J, V76, P869, DOI 10.1016/S0006-3495(99)77250-4 Reddy MM, 2003, NATURE, V423, P756, DOI 10.1038/nature01694 Robbins SL, 2010, ROBBINS COTRAN PATHO Rousseau B, 2011, LARYNGOSCOPE, V121, P346, DOI 10.1002/lary.21364 Sivasankar M, 2010, OTOLARYNG HEAD NECK, V142, P79, DOI 10.1016/j.otohns.2009.09.011 Sivasankar M, 2009, LARYNGOSCOPE, V119, P602, DOI 10.1002/lary.20091 Sivasankar M, 2008, J VOICE, V22, P408, DOI 10.1016/j.jvoice.2006.11.005 Vardouniotis AS, 2009, EUR ARCH OTO-RHINO-L, V266, P795, DOI 10.1007/s00405-009-0966-z WARBURG O, 1956, SCIENCE, V123, P309, DOI 10.1126/science.123.3191.309 Wood JM, 2011, J LARYNGOL OTOL, V125, P1218, DOI 10.1017/S0022215111002234 NR 29 TC 1 Z9 1 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD JAN PY 2014 VL 123 IS 1 BP 71 EP 76 DI 10.1177/0003489414521143 PG 6 WC Otorhinolaryngology SC Otorhinolaryngology GA AA0YM UT WOS:000330823300011 PM 24574427 ER PT J AU Courson, AM Landry, AM Lott, DG Hinni, ML AF Courson, Andy M. Landry, April M. Lott, David G. Hinni, Michael L. TI Open Staple Diverticulectomy for a Large Recurrent Zenker's Diverticulum: Still a Valid Procedure SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE operative procedure; surgical stapler; Zenker's diverticulum ID PHARYNGOESOPHAGEAL DIVERTICULUM; ESOPHAGEAL; CARCINOMA; DEVICE AB Objectives: We demonstrate indications for external mechanical stapler diverticulectomy in the modern era of endoscopic treatment. We review treatment of a large diverticulum and discuss considerations that should be made in deciding on the type of surgical treatment. Methods: The index case was in a 75-year-old man who had undergone open cricopharyngeal myotomy with diverticulopexy 35 years earlier. He presented with 25 years of recurrent symptoms. A swallow study showed a 6.5 x 5.0-cm diverticulum. The diverticulum was deemed too large for standard endoscopic myotomy, so diverticulectomy was performed with a stapler. Results: The patient was discharged on postoperative day 3 without complications. A swallow study on postoperative day 5 demonstrated no diverticulum or extravasation of barium. The patient resumed a normal diet with resolution of dysphagia. Two additional patients with large Zenker's diverticula that were managed similarly are also discussed. Conclusions: Although endoscopic laser cricopharyngeal myotomy and stapler diverticulostomy have become standard treatments for Zenker's diverticulum, this case of a large recurrent diverticulum illustrates a situation in which older techniques may be preferred. Use of the mechanical stapler allowed for a shorter surgery time than traditional suture techniques, and the potential for an earlier return to a normal diet. C1 [Courson, Andy M.; Landry, April M.; Lott, David G.; Hinni, Michael L.] Mayo Clin Hosp, Dept Otolaryngol Head & Neck Surg, Phoenix, AZ USA. RP Hinni, ML (reprint author), Dept Otolaryngol Head & Neck Surg, 5777 East Mayo Blvd, Phoenix, AZ 85054 USA. CR Acharya A, 2006, LARYNGOSCOPE, V116, P1043, DOI 10.1097/01.MLG.0000217647.22938.DA Bergeron JL, 2013, OTOLARYNG HEAD NECK, V148, P223, DOI 10.1177/0194599812465726 Bloom JD, 2010, ANN OTO RHINOL LARYN, V119, P736 Bock JM, 2012, ENT-EAR NOSE THROAT, V91, P319 Bonafede JP, 1997, LARYNGOSCOPE, V107, P720, DOI 10.1097/00005537-199706000-00004 Bonavina L, 2012, SURG ENDOSC, V26, P2856, DOI 10.1007/s00464-012-2261-0 Busaba NY, 2001, ANN OTO RHINOL LARYN, V110, P498 Carlini Massimo, 2007, Chir Ital, V59, P397 CHAPLIN JM, 1994, AUST NZ J SURG, V64, P501, DOI 10.1111/j.1445-2197.1994.tb02266.x DORION D, 1994, J OTOLARYNGOL, V23, P145 FATSIS ME, 1991, SCAND J THORAC CARD, V25, P195, DOI 10.3109/14017439109099039 Hillel AT, 2009, LARYNGOSCOPE, V119, P39, DOI 10.1002/lary.20019 HOEHN JG, 1969, MAYO CLIN PROC, V44, P738 KONOWITZ PM, 1989, OTOLARYNG HEAD NECK, V100, P146 PAGLIERO KM, 1985, CLIN OTOLARYNGOL, V10, P263, DOI 10.1111/j.1365-2273.1985.tb00252.x Rizzetto C, 2008, J GASTROINTEST SURG, V12, P2057, DOI 10.1007/s11605-008-0684-7 Smith SR, 2002, ARCH OTOLARYNGOL, V128, P141 Visosky AMB, 2008, ANN OTO RHINOL LARYN, V117, P531 WYCHULIS AR, 1969, SURGERY, V66, P976 NR 19 TC 0 Z9 0 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD DEC PY 2013 VL 122 IS 12 BP 729 EP 733 PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA 278VW UT WOS:000328919000001 PM 24592574 ER PT J AU Toros, SZ Karaca, CT Onder, S Caypinar, B Sahin-Yilmaz, A Oysu, C AF Toros, Sema Zer Karaca, Cigdem Tepe Onder, Serap Caypinar, Basak Sahin-Yilmaz, Asli Oysu, Cagatay TI Nasal Obstruction and Unilateral Chronic Otitis Media: Evaluation by Acoustic Rhinometry SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE acoustic rhinometry; chronic otitis media; nasal obstruction ID EUSTACHIAN-TUBE FUNCTION; MIDDLE-EAR PRESSURE; SEPTOPLASTY; SURGERY; CYCLE; NOSE AB Objectives: In a prospective study at Umraniye Research and Education Hospital, we aimed to evaluate the differences in acoustic rhinometric findings between the affected and nonaffected sides inpatients with unilateral chronic otitis media (COM) and to investigate whether unilateral COM correlates with the side of nasal obstruction. Methods: Fifty-five consecutive patients with unilateral COM were involved in this study. All patients were evaluated with acoustic rhinometry, the Nasal Obstruction Symptom Evaluation (NOSE) scale, and measurement of their nasal mucociliary transport time. Results: The mean cross-sectional area 1, mean cross-sectional area 2, volume 1, and volume 2 values were not different between the affected and nonaffected sides (p > 0.05). The NOSE score had a reverse correlation with the mean cross-sectional area 2 (p < 0.05) and volume 2 (p < 0.01) of the affected side. Saccharin time was not correlated with the acoustic rhinometric values of the affected side (p > 0.05). Conclusions: These findings do not support the hypothesis that unilateral COM is correlated with the side of nasal obstruction. C1 [Toros, Sema Zer; Onder, Serap; Caypinar, Basak; Sahin-Yilmaz, Asli; Oysu, Cagatay] Umraniye Educ & Res Hosp, Dept Otorhinolaryngol Head & Neck Surg, Istanbul, Turkey. [Karaca, Cigdem Tepe] Haydarpasa Numune Educ & Res Hosp, Dept Otorhinolaryngol Head & Neck Surg, Istanbul, Turkey. RP Toros, SZ (reprint author), Kent Life Sitesi A1-3,D 30, Istanbul, Turkey. CR Bakhshaee M, 2011, EUR ARCH OTO-RHINO-L, V268, P87, DOI 10.1007/s00405-010-1290-3 Buchman CA, 1999, ACTA OTO-LARYNGOL, V119, P351 Cingi C, 2005, J LARYNGOL OTOL, V119, P443 Guclu O, 2013, EUR ARCH OTO-RHINO-L, V270, P1263, DOI 10.1007/s00405-012-2122-4 HILBERG O, 1989, J APPL PHYSIOL, V66, P295 Hone SW, 1997, CLIN OTOLARYNGOL, V22, P511, DOI 10.1046/j.1365-2273.1997.00062.x Huang ZL, 2003, OTOLARYNG HEAD NECK, V128, P510, DOI 10.1016/mhn.2003.131 Kjaergaard T, 2008, LARYNGOSCOPE, V118, P1476, DOI 10.1097/MLG.0b013e318173a025 Lang C, 2003, LARYNGOSCOPE, V113, P284, DOI 10.1097/00005537-200302000-00016 LOW WK, 1993, CLIN OTOLARYNGOL, V18, P308, DOI 10.1111/j.1365-2273.1993.tb00854.x Maier W, 1998, LARYNGO RHINO OTOL, V77, P682, DOI 10.1055/s-2007-997224 Salvinelli F, 2005, CLIN OTOLARYNGOL, V30, P409, DOI 10.1111/j.1365-2273.2005.01052.x Stewart MG, 2004, OTOLARYNG HEAD NECK, V130, P283, DOI 10.1016/j.otohns.2003.12.004 Trindade Inge Elly Kiemle, 2007, Braz J Otorhinolaryngol, V73, P32 WATSON C, 1990, CLIN OTOLARYNGOL, V15, P435, DOI 10.1111/j.1365-2273.1990.tb00497.x NR 15 TC 0 Z9 1 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD DEC PY 2013 VL 122 IS 12 BP 734 EP 736 PG 3 WC Otorhinolaryngology SC Otorhinolaryngology GA 278VW UT WOS:000328919000002 PM 24592575 ER PT J AU Imaizumi, M Sato, Y Yang, DT Thibeault, SL AF Imaizumi, Mitsuyoshi Sato, Yuka Yang, David T. Thibeault, Susan L. TI In Vitro Epithelial Differentiation of Human Induced Pluripotent Stem Cells for Vocal Fold Tissue Engineering SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE hiPS; hyaluronic acid hydrogel; induced pluripotent stem cell; tissue engineering; vocal fold ID SYNTHETIC EXTRACELLULAR-MATRIX; EPIDERMAL-GROWTH-FACTOR; LAMINA PROPRIA; GENE-EXPRESSION; REGENERATION; FIBROBLASTS; PROLIFERATION; HYALURONAN; VISCOELASTICITY; INJECTION AB Objectives: We determined the feasibility and optimization of differentiating human induced pluripotent stem cells (hiPS) into nonkeratinized stratified squamous epithelial cells for vocal fold engineering. Methods: hiPS were cultured and assessed for differentiation in 3 conditions: a 3-dimensional (3D) hyaluronic acid (HA) hydrogel scaffold, a 3D HA hydrogel scaffold with epidermal growth factor (EGF), and a 3D HA hydrogel scaffold co-cultured with human vocal fold fibroblasts (hVFF). After 1, 2, and 4 weeks of cultivation, hiPS were selected for histology, immunohistochemistry, and/or transcript expression analysis. Results: At 4 weeks, hiPS cultivated with hVFF or with EGF had significantly decreased levels of Oct 3/4, indicating loss of pluripotency. Immunofluorescence revealed the presence of pancytokeratin and of cytokeratin (CK) 13 and 14 epithelial-associated proteins at 4 weeks after cultivation in hiPS EGF and hiPS hVFF cultures. The transcript expression level of CK14 was significantly increased for hiPS hVFF cultures only and was measured concomitantly with cell morphology that was clearly cohesive and displayed a degree of nuclear polarity suggestive of epithelial differentiation. Conclusions: We found that hiPS cultivated in 3D HA hydrogel with hVFF demonstrated the most robust conversion evidence to date of epithelial differentiation. Further work is necessary to focus on amplification of these progenitors for application in vocal fold regenerative biology. C1 [Imaizumi, Mitsuyoshi; Sato, Yuka; Thibeault, Susan L.] Univ Wisconsin, Div Otolaryngol Head & Neck Surg, Madison, WI 53705 USA. [Yang, David T.] Univ Wisconsin, Dept Pathol & Lab Med, Madison, WI 53705 USA. [Imaizumi, Mitsuyoshi] Fukushima Med Univ, Dept Otolaryngol, Fukushima, Japan. RP Thibeault, SL (reprint author), Univ Wisconsin, 5107 WIMR,1111 Highland Ave, Madison, WI 53705 USA. FU NIH-NIDCD [R01 4336, R01 DC012773]; Fukushima Medical University FX This work was supported by NIH-NIDCD grants R01 4336 and R01 DC012773 and by Fukushima Medical University. CR Adewumi O, 2007, NAT BIOTECHNOL, V25, P803, DOI 10.1038/nbt1318 Balda MS, 2003, TRENDS CELL BIOL, V13, P310, DOI 10.1016/S0962-8924(03)00105-3 Caton T, 2007, LARYNGOSCOPE, V117, P516, DOI 10.1097/MLG.0b013e31802e9291 Catten M, 1998, OTOLARYNG HEAD NECK, V118, P663, DOI 10.1177/019459989811800516 Cedervall J, 2007, LARYNGOSCOPE, V117, P2075, DOI 10.1097/MLG.0b013e3181379c7c Chen X, 2008, LARYNGOSCOPE, V118, P1700, DOI [10.1097/MLG.0b013e31817aec6c, 10.1097/MLG.0b013e31817acc6c] Chhetri DK, 2004, OTOLARYNG HEAD NECK, V131, P864, DOI 10.1016/j.otohns.2004.07.010 Duflo S, 2006, TISSUE ENG, V12, P3201, DOI 10.1089/ten.2006.12.3201 Gray SD, 2000, OTOLARYNG CLIN N AM, V33, P679, DOI 10.1016/S0030-6665(05)70237-1 HANEJI T, 1991, J ENDOCRINOL, V128, P383, DOI 10.1677/joe.0.1280383 Hansen JK, 2006, J VOICE, V20, P110, DOI 10.1016/j.jvoice.2004.12.005 Hanson SE, 2010, LARYNGOSCOPE, V120, P546, DOI 10.1002/lary.20797 He JC, 2008, INVEST OPHTH VIS SCI, V49, P2936, DOI 10.1167/iovs.07-0900 Hematti Peiman, 2008, Transplant Rev (Orlando), V22, P262, DOI 10.1016/j.trre.2008.05.002 Heo JS, 2006, AM J PHYSIOL-CELL PH, V290, pC123, DOI 10.1152/ajpcell.00142.2005 Imaizumi M, 2010, ANN OTO RHINOL LARYN, V119, P697 Imaizumi M, 2013, CELL TRANSPLANT, V22, P341, DOI 10.3727/096368912X653147 Johnson BQ, 2010, LARYNGOSCOPE, V120, P537, DOI 10.1002/lary.20782 Kanemaru SI, 2003, ANN OTO RHINOL LARYN, V112, P915 Leydon C, 2011, J SPEECH LANG HEAR R, V54, P1060, DOI 10.1044/1092-4388(2010/10-0267) Long JL, 2010, LARYNGOSCOPE, V120, P125, DOI 10.1002/lary.20719 Oishi K, 2009, CELL TRANSPLANT, V18, P581 Rousseau B, 2011, LARYNGOSCOPE, V121, P346, DOI 10.1002/lary.21364 Sakurai M, 2011, J ARTIF ORGANS, V14, P58, DOI 10.1007/s10047-010-0547-3 Senju S, 2009, STEM CELLS, V27, P1021, DOI 10.1002/stem.33 Shu XZ, 2004, J BIOMED MATER RES A, V68A, P365, DOI 10.1002/jbm.a.20002 Shu XZ, 2003, BIOMATERIALS, V24, P3825, DOI 10.1016/S0142-9612(03)00267-9 Sneddon JB, 2012, NATURE, V491, P765, DOI 10.1038/nature11463 Solchaga LA, 2010, TISSUE ENG PT A, V16, P1009, DOI 10.1089/ten.TEA.2009.0100 Takahashi K, 2006, CELL, V126, P663, DOI 10.1016/j.cell.2006.07.024 TAKETANI Y, 1983, ENDOCRINOLOGY, V113, P871 Tashiro K, 2009, STEM CELLS, V27, P1802, DOI 10.1002/stem.108 Thibeault SL, 2008, ANN OTO RHINOL LARYN, V117, P221 Yamaguchi T, 1996, ARCH OTOLARYNGOL, V122, P649 Yoshida S, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0028856 Yu JY, 2007, SCIENCE, V318, P1917, DOI 10.1126/science.1172482 Zhang XT, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0041613 Zheng Shu X, 2004, BIOMATERIALS, V25, P1339 NR 38 TC 1 Z9 1 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD DEC PY 2013 VL 122 IS 12 BP 737 EP 747 PG 11 WC Otorhinolaryngology SC Otorhinolaryngology GA 278VW UT WOS:000328919000003 PM 24592576 ER PT J AU Lafer, M Achlatis, S Lazarus, C Fang, YX Branski, RC Amin, MR AF Lafer, Marissa Achlatis, Stratos Lazarus, Cathy Fang, Yixin Branski, Ryan C. Amin, Milan R. TI Temporal Measurements of Deglutition in Dynamic Magnetic Resonance Imaging Versus Videofluoroscopy SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE deglutition; dynamic imaging; dysphagia; real-time magnetic resonance imaging; swallowing ID SWALLOWING FUNCTION; BODY POSITION; DYSPHAGIA; GRAVITY AB Objectives: We undertook to provide data regarding temporal measurements of swallow function obtained by dynamic magnetic resonance imaging in a midsagittal plane and to compare these values to normative fluoroscopy data. Methods: Seventeen healthy female volunteers with no swallowing complaints underwent turbo-fast low-angle shot magnetic resonance imaging with a 3-T scanner while swallowing liquid and pudding boluses delivered via syringe. Ninety sequential images were acquired with a temporal resolution of 113 ms per frame for each swallow. The imaging was performed in the midsagittal plane. The analyses focused on oral and pharyngeal transit times. Results: All subjects tolerated the protocol without complaints or adverse events. The mean (+/- SD) oral transit times for liquids and pudding were measured as 0.25 +/- 0.09 second and 0.25 +/- 0.13 second, respectively. This difference was not statistically significant (p = 0.74). The mean pharyngeal transit times for liquids and pudding were measured as 0.84 +/- 0.16 second and 1.11 +/- 0.21 seconds, respectively. This difference achieved statistical significance (p < 0.0001). The intrarater and inter-rater reliabilities for the measurements were excellent. Conclusions: This sequence provided a high degree of temporal resolution of deglutition in the midsagittal plane. Furthermore, the temporal measurements acquired with dynamic magnetic resonance imaging were reliable and were relatively consistent with those of previous studies done with videofluoroscopy. C1 [Lafer, Marissa; Achlatis, Stratos; Branski, Ryan C.; Amin, Milan R.] NYU, Voice Ctr, Dept Otolaryngol Head & Neck Surg, New York, NY 10016 USA. [Fang, Yixin] NYU, Dept Populat Hlth, Div Biostat, Sch Med, New York, NY 10016 USA. [Lazarus, Cathy] Beth Israel Deaconess Med Ctr, Thyroid Head & Neck Canc Fdn, Thyroid Head & Neck Res Ctr, New York, NY 10003 USA. RP Amin, MR (reprint author), NYU, Voice Ctr, 345 E 37th St,Suite 306, New York, NY 10016 USA. CR Altman KW, 2010, ARCH OTOLARYNGOL, V136, P784, DOI 10.1001/archoto.2010.129 Amin MR, 2012, LARYNGOSCOPE, V122, P860, DOI 10.1002/lary.22496 Amin MR, 2013, ANN OTO RHINOL LARYN, V122, P145 Aviv JE, 1998, DYSPHAGIA, V13, P87, DOI 10.1007/PL00009561 Barkmeier JM, 2002, J APPL PHYSIOL, V93, P740, DOI 10.1152/japplphysiol.00380.2001 BORGSTROM PS, 1989, ACTA RADIOL, V30, P183 Cook I J, 1989, Dysphagia, V4, P8, DOI 10.1007/BF02407397 DEJAEGER E, 1994, DIGEST DIS SCI, V39, P762, DOI 10.1007/BF02087420 DODDS WJ, 1990, AM J ROENTGENOL, V154, P953 Falsetti P, 2009, J STROKE CEREBROVASC, V18, P329, DOI 10.1016/j.jstrokecerebrovasdis.2009.01.009 Hamlet S L, 1989, Dysphagia, V4, P4, DOI 10.1007/BF02407396 Jean A, 2001, PHYSIOL REV, V81, P929 Jean A, 1990, NEUROPHYSIOLOGY JAWS, P294 JOHNSSON F, 1995, AM J PHYSIOL-GASTR L, V269, pG653 McCullough GH, 2007, TOP GERIATR REHABIL, V23, P290 Miller JL, 1997, DYSPHAGIA, V12, P125, DOI 10.1007/PL00009526 Molfenter SM, 2012, DYSPHAGIA, V27, P162, DOI 10.1007/s00455-012-9397-x RADEMAKER AW, 1994, J SPEECH HEAR RES, V37, P314 Roy N, 2007, ANN OTO RHINOL LARYN, V116, P858 SHAKER R, 1994, GASTROENTEROLOGY, V107, P396 SHROUT PE, 1979, PSYCHOL BULL, V86, P420, DOI 10.1037//0033-2909.86.2.420 Sonies B C, 1988, Dysphagia, V3, P1, DOI 10.1007/BF02406274 Tracy J F, 1989, Dysphagia, V4, P90, DOI 10.1007/BF02407151 West B. T., 2007, LINEAR MIXED MODELS NR 24 TC 1 Z9 1 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD DEC PY 2013 VL 122 IS 12 BP 748 EP 753 PG 6 WC Otorhinolaryngology SC Otorhinolaryngology GA 278VW UT WOS:000328919000004 PM 24592577 ER PT J AU Jacobi, I van Rossum, MA van der Molen, L Hilgers, FJM van den Brekel, MWM AF Jacobi, Irene van Rossum, Maya A. van der Molen, Lisette Hilgers, Frans J. M. van den Brekel, Michiel W. M. TI Acoustic Analysis of Changes in Articulation Proficiency in Patients With Advanced Head and Neck Cancer Treated With Chemoradiotherapy SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE acoustics; articulation; chemoradiotherapy; head and neck cancer; speech ID OROPHARYNGEAL CANCER; SPEECH; TONGUE; CHEMORADIATION; DISORDERS; OUTCOMES; DYSPHAGIA; THERAPY; MUSCLES; VOICE AB Objectives: Our aim was to characterize articulation proficiency and differences between tumor sites before and after chemoradiotherapy for advanced head and neck cancer with the help of acoustic measures. Our further goal was to improve objective speech measures and gain insight into muscle functioning before and after treatment. Methods: In 34 patients with laryngeal or hypopharyngeal, nasal or nasopharyngeal, or oral or oropharyngeal cancer, we acoustically analyzed nasality, vowel space, precision, and strength of articulation in 12 speech sounds (/alpha/, /i/, /u/, /p/, /s/, /z/, /1/, /t/, /tj/, /k/, /x/, /r/) before treatment and 10 weeks and 1 year after treatment. Outcomes were compared between assessment points and between tumor sites. Results: Nasality in nonlaryngeal sites was significantly reduced by treatment. Most affected in articulation were the oral or oropharyngeal cancer sites, followed by the nasal or nasopharyngeal sites. One year after treatment, vowel space had not recovered and consonant articulation had weakened. Laryngeal sites were less affected in articulation by tumor or treatment. Conclusions: Analyses of articulatory-acoustic features are a useful instrument for assessing articulation and speech quality objectively. Assessment of a number of sounds representing various articulation manners, places, and tongue shapes revealed patterns of speech deterioration after chemoradiotherapy. The results suggest that patients' speech could benefit from articulation exercises to address changes in muscle coordination and/or sensitivity and to counteract side effects and "underexercise" atrophy. C1 [Jacobi, Irene; van der Molen, Lisette; Hilgers, Frans J. M.; van den Brekel, Michiel W. M.] Netherlands Canc Inst, Dept Head & Neck Oncol & Surg, NL-1066 CX Amsterdam, Netherlands. [Hilgers, Frans J. M.; van den Brekel, Michiel W. M.] Univ Amsterdam, Acad Med Ctr, NL-1105 AZ Amsterdam, Netherlands. [Hilgers, Frans J. M.; van den Brekel, Michiel W. M.] Univ Amsterdam, Inst Phonet Sci, Amsterdam Ctr Language & Commun, NL-1105 AZ Amsterdam, Netherlands. [van Rossum, Maya A.] Univ Med Ctr Leiden, Dept Ear, Leiden, Netherlands. RP Jacobi, I (reprint author), Netherlands Canc Inst, Plesmanlaan 121, NL-1066 CX Amsterdam, Netherlands. CR Boersma Paul, 2012, PRAAT DOING PHONETIC Borggreven PA, 2005, HEAD NECK-J SCI SPEC, V27, P785, DOI 10.1002/hed.20236 de Bruijn MJ, 2009, FOLIA PHONIATR LOGO, V61, P180, DOI 10.1159/000219953 Dharmaperwira-Prins R., 2005, DYSARTRIE VERBALE AP Eisbruch A, 2004, INT J RADIAT ONCOL, V60, P1425, DOI 10.1016/j.ijrobp.2004.05.050 Givens DJ, 2009, ARCH OTOLARYNGOL, V135, P1209, DOI 10.1001/archoto.2009.174 Jacobi I, 2010, P INT 2010 MAK JAP, P2582 Jacobi I, 2010, EUR ARCH OTO-RHINO-L, V267, P1495, DOI 10.1007/s00405-010-1316-x Kent RD, 2003, CLIN LINGUIST PHONET, V17, P427, DOI 10.1080/0269920031000086248 Keuning KHDM, 2002, CLEFT PALATE-CRAN J, V39, P277, DOI 10.1597/1545-1569(2002)039<0277:TCBNAA>2.0.CO;2 Kissane DW, 2013, HEAD NECK-J SCI SPEC, V35, P172, DOI 10.1002/hed.22943 Kotz T, 1999, ARCH OTOLARYNGOL, V125, P410 Laaksonen JP, 2010, CLIN LINGUIST PHONET, V24, P41, DOI 10.3109/02699200903340758 Lallh AK, 2000, J SPEECH LANG HEAR R, V43, P782 Lazarus CL, 2009, PERSPECTIVES SWALLOW, V18, P55 LOGEMANN JA, 1993, J SPEECH HEAR RES, V36, P918 Logemann JA, 2008, HEAD NECK-J SCI SPEC, V30, P148, DOI 10.1002/hed.20672 Marchal A., 2009, SPEECH PHYSL LINGUIS Miller JL, 2002, J SPEECH LANG HEAR R, V45, P51, DOI 10.1044/1092-4388(2002/004) Mlynarek AM, 2008, J OTOLARYNGOL-HEAD N, V37, P2, DOI 10.2310/7070.2008.1001 Palmer PM, 2008, J SPEECH LANG HEAR R, V51, P828, DOI 10.1044/1092-4388(2008/060) Pittman LJ, 2009, J NEUROPHYSIOL, V101, P276, DOI 10.1152/jn.91065.2008 Raphael LJ, 2006, SPEECH SCI PRIMER PH Rieger JM, 2010, J OTOLARYNGOL-HEAD N, V39, P523, DOI 10.2310/7070.2010.090339 Robbins J, 2008, J SPEECH LANG HEAR R, V51, pS276, DOI 10.1044/1092-4388(2008/021) Schuster M, 2012, Oral Maxillofac Surg, V16, P291, DOI 10.1007/s10006-012-0340-y Singer S, 2013, HEAD NECK-J SCI SPEC, V35, P1331, DOI 10.1002/hed.23127 Stal P, 2003, CELLS TISSUES ORGANS, V173, P147, DOI 10.1159/000069470 Stevens K.N., 2000, ACOUSTIC PHONETICS Stone M, 1996, J ACOUST SOC AM, V99, P3728, DOI 10.1121/1.414969 van der Molen L, 2012, J VOICE, V26, pe25, DOI DOI 10.1016/J.JV0ICE.2011.08.016 van der Molen L, 2011, DYSPHAGIA, V26, P155, DOI 10.1007/s00455-010-9288-y NR 32 TC 1 Z9 1 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD DEC PY 2013 VL 122 IS 12 BP 754 EP 762 PG 9 WC Otorhinolaryngology SC Otorhinolaryngology GA 278VW UT WOS:000328919000005 PM 24592578 ER PT J AU Sbaihat, A Bacciu, A Pasanisi, E Sanna, M AF Sbaihat, Ahmad Bacciu, Andrea Pasanisi, Enrico Sanna, Mario TI Skull Base Chondrosarcomas: Surgical Treatment and Results SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE chondrosarcoma; clivus; petrous apex; skull base tumor; surgery; temporal bone ID INFRATEMPORAL FOSSA APPROACH; TEMPORAL BONE; JUGULAR FORAMEN; POSTERIOR-FOSSA; TUMORS; CHORDOMA; DIAGNOSIS; REMOVAL; THERAPY; SINUS AB Objectives: We describe our experience in the management of patients with skull base chondrosarcoma, an uncommon neoplasm of the skull base. Methods: Thirteen cases of surgically treated skull base chondrosarcomas were identified. The patients' follow-ups ranged from 7 to 86 months (mean, 47 months). Results: The most common tumor locations were the jugular foramen (5 cases), the petrous apex (3 cases), and the petroclival region (3 cases). An infratemporal fossa type A approach was performed in 2 cases, and 2 patients underwent an infratemporal fossa type B approach. Two patients underwent a transotic approach, 1 patient underwent a petro-occipital transsigmoid approach, and a petro-occipital transsigmoid approach combined with a transotic approach was chosen in 1 case. One patient underwent an infratemporal fossa type C approach combined with a transotic approach, and 2 patients underwent an infratemporal fossa type B approach combined with a transotic approach. One patient underwent an infratemporal fossa type B approach combined with a transzygomatic approach, and the last patient underwent a transmastoid approach. Gross total tumor removal was achieved in all patients. Postoperative radiotherapy was performed in 7 cases. The most common complications were lower cranial nerve deficits. Two patients experienced recurrences, 36 months and 6 years after surgical removal. Conclusions: We believe that the primary treatment for chondrosarcomas of the skull base is gross total surgical resection. We usually do not recommend radiotherapy as the primary treatment for patients with skull base chondrosarcomas; however, radiotherapy may be considered as an alternative primary treatment in selected cases in which there are serious medical contraindications to surgery, as well as in elderly patients. We reserve postoperative radiotherapy for patients with histologically aggressive tumors (grade II or III) as well as for cases of subtotal resection or recurrent tumors. C1 [Sbaihat, Ahmad; Sanna, Mario] Grp Otol Piacenza Rome, Rome, Italy. [Sanna, Mario] Univ G dAnnunzio, Dept Oral & Nanobiotechnol Sci, Chieti, Italy. [Bacciu, Andrea; Pasanisi, Enrico] Univ Hosp Parma, Head & Neck Dept, I-43100 Parma, Italy. RP Bacciu, A (reprint author), Univ Hosp Parma, Head & Neck Dept, Via Gramsci 14, I-43100 Parma, Italy. CR Almefty K, 2007, CANCER, V110, P2457, DOI 10.1002/cncr.23073 ALMEFTY O, 1987, SURG NEUROL, V28, P423, DOI 10.1016/0090-3019(87)90224-2 BLEVINS NH, 1995, LARYNGOSCOPE, V105, P975, DOI 10.1288/00005537-199509000-00018 Brackmann DE, 2006, OTOL NEUROTOL, V27, P98 CIANFRIGLIA F, 1978, ACTA NEUROCHIR, V45, P163, DOI 10.1007/BF01774391 COLTRERA MD, 1986, CANCER, V58, P2689, DOI 10.1002/1097-0142(19861215)58:12<2689::AID-CNCR2820581224>3.0.CO;2-P Crockard HA, 2001, J NEUROSURG, V95, P184, DOI 10.3171/jns.2001.95.2.0184 Donaldson DR, 1999, ARCH OTOLARYNGOL, V125, P229 FISCH U, 1978, J LARYNGOL OTOL, V92, P949, DOI 10.1017/S0022215100086382 Fuji H, 2011, SKULL BASE-INTERD AP, V21, P201, DOI 10.1055/s-0031-1275636 HARVEY SA, 1994, AM J OTOL, V15, P257 House J W, 1985, HEAD NECK SURG, V93, P146 Hug EB, 1999, J NEUROSURG, V91, P432, DOI 10.3171/jns.1999.91.3.0432 Korten AGGC, 1998, J NEUROL NEUROSUR PS, V65, P88, DOI 10.1136/jnnp.65.1.88 Krishnan S, 2005, NEUROSURGERY, V56, P777, DOI 10.1227/01.NEU.0000156789.10394.F5 KVETON JF, 1986, OTOLARYNG HEAD NECK, V94, P23 LALWANI AK, 1992, NEUROSURGERY, V31, P1008 Lau DPC, 1997, J LARYNGOL OTOL, V111, P368 Lustig LR, 2007, J LARYNGOL OTOL, V121, P725, DOI 10.1017/S0022215107006081 MAZZONI A, 1995, SKULL BASE SURG, V5, P157, DOI 10.1055/s-2008-1058930 Megerian CA, 1996, AM J OTOL, V17, P773 Oghalai JS, 2005, OTOL NEUROTOL, V26, P1052, DOI 10.1097/01.mao.0000185076.65822.f7 Raghu M, 2004, J LARYNGOL OTOL, V118, P551 Rosenberg AE, 1999, AM J SURG PATHOL, V23, P1370, DOI 10.1097/00000478-199911000-00007 Samii A, 2009, NEUROSURG REV, V32, P67, DOI 10.1007/s10143-008-0170-4 SAMII M, 1988, ACTA NEUROCHIR, V95, P6, DOI 10.1007/BF01793075 Sanna M, 2008, ATLAS MICROSURGER LA Sanna M, 2006, LARYNGOSCOPE, V116, P742, DOI 10.1097/01.mlg.0000205199.61105.cb Sanna M, 2008, LARYNGOSCOPE, V118, P1719, DOI 10.1097/MLG.0b013e31817f93bb SEKHAR LN, 1987, J NEUROSURG, V67, P488, DOI 10.3171/jns.1987.67.4.0488 Tzortzidis F, 2006, NEUROSURGERY, V58, P1090, DOI 10.1227/01.NEU.0000215892.65663.54 WATTERS GWR, 1995, CLIN OTOLARYNGOL, V20, P53 Williams PL, 1989, GRAYS ANATOMY, V37th NR 33 TC 0 Z9 0 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD DEC PY 2013 VL 122 IS 12 BP 763 EP 770 PG 8 WC Otorhinolaryngology SC Otorhinolaryngology GA 278VW UT WOS:000328919000006 PM 24592579 ER PT J AU Stein, DJ Noordzij, JP AF Stein, Daniel J. Noordzij, J. Pieter TI Incidence of Chronic Laryngitis SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE chronic laryngitis; incidence; laryngitis; prevalence ID POPULATION; PREVALENCE AB Objectives: We describe the incidence of chronic laryngitis (CL) and identify the most common presenting symptoms and initial treatments used. Methods: We retrospectively identified patients with a diagnosis of CL who were seen among a primary care cohort at an urban academic medical center from 2009 to 2010. The incidence of CL was calculated. Symptoms, first-visit treatment, smoking, and demographics were recorded. Results: Of a population of 40,317 people, 280 received a new diagnosis of CL over a 2-year period, representing a yearly incidence of 3.47 cases per 1,000 people. The subjects consisted of 160 women and 120 men. Race was recorded as black (126), Hispanic (47), white (68), or other (39). The mean age was 52.9 years (range, 20 to 90 years). The initial therapies included proton pump inhibitors (79%), voice therapy (17%), nasal steroid (13%), antihistamine (4%), amitriptyline (4%), other (17%), and none (11%). The most common symptoms were dysphonia (53%), pain/soreness (45%), globus sensation (40%), cough (33%), excessive throat clearing (28%), and dysphagia (32%). An otolaryngologist saw 93% of the cases. Conclusions: The yearly CL incidence was 3.47 per 1,000 people. Up to 21% of the population may develop CL in their lifetime. Most of the patients in this cohort were referred to otolaryngologists, and the majority were treated with proton pump inhibitors. Dysphonia, globus sensation, and pain were the most common symptoms. Population surveys could be used to define undiagnosed disease and the overall prevalence of CL. C1 [Stein, Daniel J.; Noordzij, J. Pieter] Boston Med Ctr, Dept Otolaryngol Head & Neck Surg, Boston, MA USA. RP Noordzij, JP (reprint author), 4th Floor,FGH Bldg,820 Harrison Ave, Boston, MA 02118 USA. CR Baletic N, 2005, IND HEALTH, V43, P302, DOI 10.2486/indhealth.43.302 Chen Hk, 2012, Australas Med J, V5, P175, DOI 10.4066/AMJ.2012.1101 Coyle SM, 2001, J VOICE, V15, P424, DOI 10.1016/S0892-1997(01)00043-1 Kim JSC, 2012, OTOLARYNG HEAD NECK, V146, P196, DOI 10.1177/0194599811433977 Merati AL, 2010, CUMMINGS OTOLARYNGOL, P901 Roy N, 2005, LARYNGOSCOPE, V115, P1988, DOI 10.1097/01.mlg.0000179174.32345.41 Schwartz SR, 2009, OTOLARYNG HEAD NECK, V141, pS1, DOI 10.1016/j.otohns.2009.06.744 Tulunay OE, 2008, OTOLARYNG CLIN N AM, V41, P437, DOI 10.1016/j.otc.2007.11.012 NR 8 TC 0 Z9 0 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD DEC PY 2013 VL 122 IS 12 BP 771 EP 774 PG 4 WC Otorhinolaryngology SC Otorhinolaryngology GA 278VW UT WOS:000328919000007 PM 24592580 ER PT J AU Shah, AT Wein, RO AF Shah, Ameer T. Wein, Richard O. TI Management of a Postradiation Esophageal Web in the Setting of a Coexisting Zenker's Diverticulum SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE dysphagia; esophageal stenosis; radiotherapy; Zenker's diverticulum ID NECK-CANCER; RADIATION-THERAPY; HEAD; CHEMORADIATION; RADIOTHERAPY; CARCINOMA; DYSPHAGIA; STRICTURE; COMPLICATIONS; PUNCTURE AB We present a case of postradiation obstructive esophageal web, seen in the setting of a coexisting Zenker's diverticulum, that was treated with combined anterograde and retrograde esophagoscopy puncture and dilation. We also review the relevant literature. Obstructing esophageal webs and stenoses are well-documented complications seen in patients with head and neck cancer treated with radiation therapy. For thin webs, combined anterograde and retrograde esophagoscopy along with puncture and dilation can be a relatively safe treatment option for selected patients. The presence of a coexisting Zenker's diverticulum may predispose the patient to the development of postradiation esophageal complications and make subsequent assessment more difficult to perform. C1 [Shah, Ameer T.; Wein, Richard O.] Tufts Med Ctr, Dept Otolaryngol Head & Neck Surg, Boston, MA USA. RP Shah, AT (reprint author), 800 Washington St,Box 850, Boston, MA 02111 USA. CR Best SR, 2011, HEAD NECK-J SCI SPEC, V33, P1727, DOI 10.1002/hed.21657 Caglar HB, 2008, INT J RADIAT ONCOL, V72, P1110, DOI 10.1016/j.ijrobp.2008.02.048 Caudell JJ, 2010, INT J RADIAT ONCOL, V76, P403, DOI 10.1016/j.ijrobp.2009.02.017 Chen AM, 2010, HEAD NECK-J SCI SPEC, V32, P178, DOI 10.1002/hed.21164 Constantin A, 2012, J Med Life, V5, P92 GOODWIN WJ, 1984, LARYNGOSCOPE, V94, P1153 Laurell G, 2003, CANCER, V97, P1693, DOI 10.1002/cncr.11236 Lee WT, 2006, HEAD NECK-J SCI SPEC, V28, P808, DOI 10.1002/hed.20427 Lew RJ, 2004, HEAD NECK-J SCI SPEC, V26, P179, DOI 10.1002/hed.10365 Mekhail TM, 2001, CANCER, V91, P1785, DOI 10.1002/1097-0142(20010501)91:9<1785::AID-CNCR1197>3.0.CO;2-1 Mullen TD, 2013, HEAD NECK-J SCI SPEC, V35, pE197, DOI 10.1002/hed.22975 Nguyen NP, 2006, RADIOTHER ONCOL, V80, P302, DOI 10.1016/j.radonc.2006.07.031 Petro M, 2005, AM J OTOLARYNG, V26, P353, DOI 10.1016/j.amjoto.2005.02.007 ROSWIT B, 1974, SEMIN ROENTGENOL, V9, P51, DOI 10.1016/0037-198X(74)90009-1 Sullivan CA, 2004, LARYNGOSCOPE, V114, P1924, DOI 10.1097/01.mlg.0000147921.74110.ee Teguh DN, 2008, INT J RADIAT ONCOL, V72, P1119, DOI 10.1016/j.ijrobp.2008.02.061 Tuna Y, 2012, DIGEST DIS SCI, V57, P424, DOI 10.1007/s10620-011-1875-8 Wang YG, 2002, WORLD J GASTROENTERO, V8, P766 Watemberg S, 1996, AM J GASTROENTEROL, V91, P1494 Worthington HV, 2007, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD000978.pub3 NR 20 TC 0 Z9 0 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD DEC PY 2013 VL 122 IS 12 BP 775 EP 778 PG 4 WC Otorhinolaryngology SC Otorhinolaryngology GA 278VW UT WOS:000328919000008 PM 24592581 ER PT J AU Levine, SB Truitt, T Schwartz, M Atkins, J AF Levine, Steven B. Truitt, Theodore Schwartz, Michael Atkins, James TI In-Office Stand-Alone Balloon Dilation of Maxillary Sinus Ostia and Ethmoid Infundibula in Adults With Chronic or Recurrent Acute Rhinosinusitis: A Prospective, Multi-institutional Study With-1-Year Follow-Up SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE balloon dilation; chronic rhinosinusitis; outpatient surgery; recurrent acute rhinosinusitis ID SINONASAL OUTCOME TEST; CATHETER SINUSOTOMY; SURGERY; MULTICENTER; VALIDITY; BURDEN; LONG AB Objectives: This study evaluated in-office balloon dilation of maxillary sinus ostia and ethmoid infundibula to treat chronic rhinosinusitis (CRS) and recurrent acute rhinosinusitis (RARS). Methods: Seventy-four patients with disease in the maxillary and anterior ethmoid sinuses on computed tomography were prospectively enrolled across 12 study centers. All procedures were performed in the office. The primary outcomes were clinical effectiveness and health-care utilization at 1 year, measured by the validated surveys Sino-Nasal Outcome Test (SNOT-20) and Rhinosinusitis Symptom Inventory (RSI). Results: Dilation was successful in 69 patients (93.2%), and the average periprocedural pain level was 3.2 (scale of 0 to 10). The mean improvement on the SNOT-20 at 1 year was clinically and statistically significant (p <0.0001), with no significant difference between the CRS and RARS patient outcomes. The treatment effect was the same in the CRS and RARS subgroups and was either "moderate" or "large" for 10 of 12 symptoms. The mean numbers of antibiotic courses (p <= 0.001), sinus-related physician visits (p <0.0001), and number of acute sinus infections (p <0.001) decreased significantly in both subgroups. There were no serious device-related adverse events, and the rate of revision surgery was 5.8%. Conclusions: Stand-alone balloon dilation of the maxillary sinus ostia and ethmoid infundibula performed in the office is well tolerated and effectively treats both CRS and RARS. C1 [Levine, Steven B.] Yale Univ, Sch Med, Dept Surg, Otolaryngol Sect, New Haven, CT 06510 USA. [Levine, Steven B.] ENT & Allergy Associates LLC, Trumbull, CT 06611 USA. [Truitt, Theodore] St Cloud Ear Nose & Throat, St Cloud, MN USA. [Schwartz, Michael] Ear Nose & Throat Associates South Florida, W Palm Beach, FL USA. [Atkins, James] Texas Sinus Ctr, San Antonio, TX USA. RP Levine, SB (reprint author), ENT & Allergy Associates LLC, 160 Hawley Lane,Suite 202, Trumbull, CT 06611 USA. EM slevine@entallergymd.com CR Alkire BC, 2010, LARYNGOSCOPE, V120, P631, DOI 10.1002/lary.20804 Atkins J, 2010, OPER TECH OTOLARYNGO, V21, P102 Bhattacharyya N, 2005, LARYNGOSCOPE, V115, P306, DOI 10.1097/01.mlg.000154738.40690.dd Bhattacharyya N, 2012, OTOLARYNG HEAD NECK, V146, P307, DOI 10.1177/0194599811426089 Bhattacharyya N, 2006, LARYNGOSCOPE, V116, P1805, DOI 10.1097/01.mlg.0000231786.10969.3f Bhattacharyya N, 2003, AM J RHINOL, V17, P27 Brodner D, 2013, INT FORUM ALLERGY RH, V3, P652, DOI 10.1002/alr.21156 Cutler J, 2011, INT FORUM ALLERGY RH, V1, P460, DOI 10.1002/alr.20069 Gliklich RE, 1998, OTOLARYNG HEAD NECK, V118, P344, DOI 10.1016/S0194-5998(98)70313-4 Hopkins C, 2009, CLIN OTOLARYNGOL, V34, P447, DOI 10.1111/j.1749-4486.2009.01995.x Hwang PH, 2012, ARCH OTOLARYNGOL, V138, P1077, DOI 10.1001/jamaoto.2013.603 Karanfilov B, 2013, INT FORUM ALLERGY RH, V3, P404, DOI 10.1002/alr.21112 Levine HL, 2008, ANN OTO RHINOL LARYN, V117, P263 Piccirillo JF, 2002, OTOLARYNG HEAD NECK, V126, P41, DOI 10.1067/mhn.2002.121022 Plaza G, 2011, ANN OTO RHINOL LARYN, V120, P511 Poetker DM, 2008, AM J RHINOL, V22, P329, DOI 10.2500/ajr.2008.22.3177 Rosenfeld RM, 2007, OTOLARYNG HEAD NECK, V137, pS1, DOI 10.1016/j.otohns.2007.06.726 Sillers MJ, 2013, CURR OPIN OTOLARYNGO, V21, P17, DOI 10.1097/MOO.0b013e32835c05e1 Soler ZM, 2010, OTOLARYNG HEAD NECK, V143, P621, DOI 10.1016/j.otohns.2010.07.014 Weiss RL, 2008, OTOLARYNG HEAD NECK, V139, pS38, DOI 10.1016/j.otohns.2008.06.008 NR 20 TC 4 Z9 4 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD NOV PY 2013 VL 122 IS 11 BP 665 EP 671 PG 7 WC Otorhinolaryngology SC Otorhinolaryngology GA 264XZ UT WOS:000327915600001 PM 24358625 ER PT J AU Paniello, RC Desai, SC Allen, CT Khosla, SM AF Paniello, Randal C. Desai, Shaun C. Allen, Clint T. Khosla, Siddarth M. TI Endoscopic Keel Placement to Treat and Prevent Anterior Glottic Webs SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE endoscopy; keel; larynx; surgery; web ID LARYNGEAL WEB; REPAIR; LYSIS AB We performed a retrospective chart review to examine and describe our clinical experience of use of the Lichtenberger technique to place silicone elastomer keels after lysis of existing webs or for prevention of webs following anterior cornmissure surgery in adults. Twenty-two patients were identified for inclusion, ranging in age from 24 to 80 years. For 18 patients with existing glottic webs, the surgical procedure involved laryngoscopy with complete lysis of the anterior glottic web by laser or sharp technique, followed by placement of a square of silicone elastomer that is sutured in place with the Lichtenberger needle holder and left in place for 3 to 5 weeks. The procedure was well tolerated, and successfully corrected the web in all but 2 cases. For 4 patients, the procedure was performed prophylactically at the time of anterior commissure surgery considered high-risk for web formation. The procedure does not require a tracheotomy, and patients can maintain a normal diet and have functional phonation while the keel is in place. This approach to treating anterior glottic webs offers several advantages over traditional open thyrotomy with keel placement and should be considered to treat or prevent anterior glottic webs. C1 [Paniello, Randal C.; Desai, Shaun C.; Allen, Clint T.] Washington Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, St Louis, MO 63110 USA. [Khosla, Siddarth M.] Univ Cincinnati, Sch Med, Dept Otolaryngol Head & Neck Surg, Cincinnati, OH USA. RP Paniello, RC (reprint author), Washington Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, 660 S Euclid Ave,CB 8115, St Louis, MO 63110 USA. CR BENJAMIN B, 1983, ANN OTO RHINOL LARYN, V92, P317 Benmansour N, 2012, EUR ARCH OTO-RHINO-L, V269, P2075, DOI 10.1007/s00405-012-2001-z Casiano RR, 1998, J VOICE, V12, P536, DOI 10.1016/S0892-1997(98)80062-3 Cheng ATL, 2009, INT J PEDIATR OTORHI, V73, P945, DOI 10.1016/j.ijporl.2009.03.012 Cohen SR., 1985, ANN OTO RHINOL LARYN, V94, P2 DEDO HH, 1979, ANN OTO RHINOL LARYN, V88, P467 Edwards J, 2007, ANN OTO RHINOL LARYN, V116, P211 Falk RJ, 2011, ANN RHEUM DIS, V70, P704, DOI 10.1136/ard.2011.150714 GIANCARLO H, 1985, LARYNGOSCOPE, V95, P1123, DOI 10.1288/00005537-198509000-00022 Holland BW, 2002, LARYNGOSCOPE, V112, P1926, DOI 10.1097/00005537-200211000-00003 Hsueh JY, 2000, LARYNGOSCOPE, V110, P1780, DOI 10.1097/00005537-200010000-00041 Koltai PJ, 1999, OPERATIVE TECHNIQUES, V10, P325, DOI 10.1016/S1043-1810(99)80017-7 LICHTENBERGER G, 1991, OTOLARYNG HEAD NECK, V105, P755 LICHTENBERGER G, 1994, LARYNGOSCOPE, V104, P771 Liyanage SH, 2006, J LARYNGOL OTOL, V120, P322, DOI 10.1017/S0022215106000247 McNaught RC., 1950, T AM LARYNGOL RHINOL, P232 Nicollas R, 2008, OTOLARYNG CLIN N AM, V41, P877, DOI 10.1016/j.otc.2008.04.008 PARKER DA, 1987, J LARYNGOL OTOL, V101, P1055, DOI 10.1017/S0022215100103214 Su CY, 2010, ANN OTO RHINOL LARYN, V119, P297 Unal M, 2004, INT J PEDIATR OTORHI, V68, P231, DOI 10.1016/j.ijporl.2003.09.018 NR 20 TC 1 Z9 1 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD NOV PY 2013 VL 122 IS 11 BP 672 EP 678 PG 7 WC Otorhinolaryngology SC Otorhinolaryngology GA 264XZ UT WOS:000327915600002 PM 24358626 ER PT J AU Shimizu, S Ogawa, T Seno, S Kouzaki, H Shimizu, T AF Shimizu, Shino Ogawa, Takao Seno, Satoshi Kouzaki, Hideaki Shimizu, Takeshi TI Pro-resolution Mediator Lipoxin A4 and Its Receptor in Upper Airway Inflammation SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE allergic rhinitis; chronic rhinosinusitis; formyl peptide receptor like 1; lipoxin A4; lipoxygenase; nasal polyp ID EPITHELIAL-CELLS; LIPID MEDIATORS; GENE-EXPRESSION; KAPPA-B; BIOSYNTHESIS; A(4); LIPOPOLYSACCHARIDE; 15-LIPOXYGENASE-1; INHIBITION; ACTIVATION AB Objectives: The resolution of inflammation is an active process controlled by several anti-inflammatory and pro-resolution mediators. Lipoxin A4, an endogenous lipid mediator, is a potential pro-resolution mediator that could attenuate inflammation. This study was conducted to elucidate the role of lipoxin A4 in upper airway inflammation. Methods: Nasal secretions were collected from patients with chronic rhinosinusitis with nasal polyposis, patients with allergic rhinitis, and control subjects. The concentration of lipoxin A4 was measured by enzyme-linked immunosorbent assay. Nasal tissues were obtained from nasal polyps and inferior turbinates during endonasal surgery. The mRNA expressions of lipoxygenases (LOXs), lipoxin receptor (formyl peptide receptor like 1; FPRL-1), and cysteinyl leukotriene type 1 receptor (CysLT1R) in nasal tissues were examined by reverse-transcription polymerase chain reaction. Tissue localization of FPRL-1 was determined by immunohistochemical staining. The in vitro effect of lipoxin A4 on airway epithelial cells was also examined. Results: A significant concentration of lipoxin A4 was found in nasal secretions, and the concentration was increased in patients with allergic rhinitis. The mRNA expressions of 5-LOX, 15-LOX-1, FPRL-1, and CysLT1R were significantly greater in nasal polyps than in inferior turbinates. FPRL-1 was localized in nasal epithelial cells. Lipoxin A4 inhibited tumor necrosis factor alpha-induced interleukin 8 release from airway epithelial cells via its receptor FPRL-1. Conclusions: These results indicate that lipoxin A4 may play a role in the resolution of upper airway inflammation. A low concentration of lipoxin A4 may be involved in chronic inflammation of the upper airways. C1 [Shimizu, Shino; Ogawa, Takao; Seno, Satoshi; Kouzaki, Hideaki; Shimizu, Takeshi] Shiga Univ Med Sci, Dept Otorhinolaryngol, Otsu, Shiga 5202192, Japan. RP Shimizu, S (reprint author), Shiga Univ Med Sci, Dept Otorhinolaryngol, Otsu, Shiga 5202192, Japan. CR Bonnans C, 2007, BIOMED PHARMACOTHER, V61, P261, DOI 10.1016/j.biopha.2007.02.016 Claesson HE, 2009, PROSTAG OTH LIPID M, V89, P120, DOI 10.1016/j.prostaglandins.2008.12.003 Committee of the Practical Guideline for the Management of Allergic Rhinitis, 2009, PRACT GUID MAN ALL R Global Strategy for Asthma Management and Prevention, 2006, GLOB STRAT ASTHM MAN Haworth O, 2007, EUR RESPIR J, V30, P980, DOI 10.1183/09031936.00005807 Hsi LC, 2002, J BIOL CHEM, V277, P40549, DOI 10.1074/jbc.M203522200 Jozsef L, 2002, P NATL ACAD SCI USA, V99, P13266, DOI 10.1073/pnas.202296999 Karp CL, 2004, NAT IMMUNOL, V5, P388, DOI 10.1038/ni1056 Kure I, 2010, J PHARMACOL EXP THER, V332, P541, DOI 10.1124/jpet.109.159046 Levy BD, 2005, AM J RESP CRIT CARE, V172, P824, DOI 10.1164/rccm.200410-1413OC Levy BD, 2007, FASEB J, V21, P3877, DOI 10.1096/fj.07-8653com Maderna P, 2009, BRIT J PHARMACOL, V158, P947, DOI 10.1111/j.1476-5381.2009.00386.x Mangino MJ, 2006, PROSTAG OTH LIPID M, V79, P84, DOI 10.1016/j.prostaglandins.2005.10.004 Perez-Novo CA, 2005, J ALLERGY CLIN IMMUN, V115, P1189, DOI 10.1016/j.jaci.2005.02.029 Planaguma A, 2008, AM J RESP CRIT CARE, V178, P574, DOI 10.1164/rccm.200801-061OC Romano M, 2007, THESCIENTIFICWORLDJO, V7, P1393, DOI 10.1100/tsw.2007.186 Rostkowska-Nadolska B, 2011, AURIS NASUS LARYNX, V38, P58, DOI 10.1016/j.anl.2010.05.002 Serhan CN, 2003, J IMMUNOL, V171, P6856 Thomas Mike, 2008, Prim Care Respir J, V17, P79, DOI 10.3132/pcrj.2008.00029 Wu SH, 2008, INFLAMM RES, V57, P430, DOI 10.1007/s00011-008-7147-1 NR 20 TC 2 Z9 2 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD NOV PY 2013 VL 122 IS 11 BP 683 EP 689 PG 7 WC Otorhinolaryngology SC Otorhinolaryngology GA 264XZ UT WOS:000327915600004 PM 24358628 ER PT J AU Thottam, PJ Kovacevic, L Madgy, DN Abdulhamid, I AF Thottam, Prasad John Kovacevic, Larisa Madgy, David N. Abdulhamid, Ibrahim TI Sleep Architecture Parameters That Predict Postoperative Resolution of Nocturnal Enuresis in Children With Obstructive Sleep Apnea SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE adenotonsillectomy; enuresis; obstructive sleep apnea; pediatrics; polysomnogram; sleep architecture. ID PEDIATRIC-PATIENTS; ADENOTONSILLECTOMY; POLYSOMNOGRAPHY; VALUES AB Objectives: We performed a prospective cohort study in a pediatric tertiary care center to determine whether preoperative sleep architecture is associated with complete resolution of nocturnal enuresis (NE) after adenotonsillectomy. Methods: Thirty-seven pediatric patients with primary NE who underwent adenotonsillectomy for obstructive sleep apnea (OSA) were evaluated. Preoperative polysomnograms, as well as preoperative and postoperative reports of NE, were recorded. We performed chi(2) analysis, Fisher's exact test (for p values), and t-tests to evaluate the impact of multiple demographic characteristics on sleep architecture, comparing children with resolved NE to those with unresolved NE after adenotonsillectomy. Results: The patients' mean age was 8.0 years (SD, 2.32 years). All children had presurgical primary NE. No age or gender differences were identified between children with resolved NE and those with unresolved NE. After surgery, more than half of the participants had resolution of NE. A higher percentage of boys had unresolved NE (chi(2) = 3.63; p = 0.06). Improvement of NE was identified in children with a higher obstructive apnea-hypopnea index and more desaturation events. Eleven of the 12 children with prolonged stage 2 sleep reported resolution of NE (p = 0.001). Children with an obstructive apnea-hypopnea index of greater than 10 had a significantly greater rate of resolution of NE (p = 0.01). Logistic regression demonstrated that an elevated body mass index and the interaction of severe USA and prolonged stage 2 sleep predicted resolution of NE. All 10 children with severe USA and an abnormal total time spent in stage 2 sleep had resolution of NE. Conclusions: Adenotonsillectomy is a treatment option for children with USA and NE. Postoperative resolution of NE was seen in 51.4% of patients who underwent adenotonsillectomy. The children with both severe USA and prolonged stage 2 sleep were 3.4 times as likely to have postoperative resolution of NE. These results suggest that there are significant differences in preoperative sleep architecture between children whose NE resolves after adenotonsillectomy and those whose NE does not resolve. C1 [Thottam, Prasad John; Madgy, David N.] Childrens Hosp Michigan, Detroit Med Ctr, Dept Otolaryngol, Detroit, MI 48201 USA. [Kovacevic, Larisa] Childrens Hosp Michigan, Detroit Med Ctr, Dept Urol, Detroit, MI 48201 USA. [Abdulhamid, Ibrahim] Childrens Hosp Michigan, Detroit Med Ctr, Pediat Pulm Div, Carman & Ann Adams Dept Pediat, Detroit, MI 48201 USA. [Thottam, Prasad John; Madgy, David N.] Michigan State Univ, Dept Surg Serv, Detroit, MI USA. [Kovacevic, Larisa; Abdulhamid, Ibrahim] Wayne State Univ, Dept Pediat, Detroit, MI 48202 USA. RP Thottam, PJ (reprint author), Childrens Hosp Michigan, Dept Pediat Otolaryngol, 3901 Beaubien St, Detroit, MI 48201 USA. CR Aydil U, 2008, J OTOLARYNGOL-HEAD N, V37, P235, DOI 10.2310/7070.2008.0048 Basha S, 2005, LARYNGOSCOPE, V115, P1101, DOI 10.1097/01.MLG.0000163762.13870.83 Brooks LJ, 2003, J PEDIATR-US, V142, P515, DOI 10.1067/mpd.2003.158 Church GD, 2012, CURR PROB PEDIATR AD, V42, P2, DOI 10.1016/j.cppeds.2011.10.001 COBLE PA, 1984, SLEEP, V7, P289 Dhondt K, 2009, J UROLOGY, V182, P1961, DOI 10.1016/j.juro.2009.05.103 Firoozi F, 2006, J UROLOGY, V175, P1885, DOI 10.1016/S0022-5347(05)00935-3 Greene M G, 1997, Curr Opin Pulm Med, V3, P456, DOI 10.1097/00063198-199711000-00013 Guven A, 2007, J UROLOGY, V178, P1458, DOI 10.1016/j.juro.2007.05.165 Iber C, 2007, AASM MANUAL SCORING Kaditis A, 2012, SLEEP MED, V13, P217, DOI 10.1016/j.sleep.2011.09.009 Katz E., 2005, PRINCIPLES PRACTICE, P197 Kovacevic L, 2013, J PEDIATR UROL, V9, P145, DOI 10.1016/j.jpurol.2011.12.013 Mitchell RB, 2009, DEV NEUROPSYCHOL, V34, P650, DOI 10.1080/87565640903133657 Mitchell RB, 2006, LARYNGOSCOPE, V116, P956, DOI 10.1097/01.MLG.0000216413.22408.FD Montgomery-Downs HE, 2006, PEDIATRICS, V117, P741, DOI 10.1542/peds.2005-1067 Ramakrishnan K, 2008, AM FAM PHYSICIAN, V78, P489 Redline S, 2011, SLEEP, V34, P1509, DOI 10.5665/sleep.1388 Roland PS, 2011, OTOLARYNG HEAD NECK, V145, pS1, DOI 10.1177/0194599811409837 Siddiqui F, 2006, SLEEP MED, V7, P281, DOI 10.1016/j.sleep.2005.10.006 Su MS, 2011, J PEDIATR-US, V159, P238, DOI 10.1016/j.jpeds.2011.01.036 Traeger N, 2005, PEDIATR PULM, V40, P22, DOI 10.1002/ppul.20236 Uliel S, 2004, CHEST, V125, P872, DOI 10.1378/chest.125.3.872 WEIDER DJ, 1991, OTOLARYNG HEAD NECK, V105, P427 Wong TK, 2004, SLEEP, V27, P1139 NR 25 TC 0 Z9 0 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD NOV PY 2013 VL 122 IS 11 BP 690 EP 694 PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA 264XZ UT WOS:000327915600005 PM 24358629 ER PT J AU Leong, SC Lesser, TH AF Leong, Samuel C. Lesser, Tristram H. TI Long-Term Outcomes of Facial Nerve Function in Irradiated and Nonirradiated Nerve Grafts SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE facial nerve; facial nerve repair; facial paralysis; parotid cancer; radiotherapy ID QUALITY-OF-LIFE; PARALYZED FACE; NECK-CANCER; REANIMATION; REPAIR; PAROTIDECTOMY; RADIOTHERAPY; ANASTOMOSIS; HEAD AB Objectives: We reviewed the long-term results of facial nerve repair in a tertiary head and neck institution in the north of England. Methods: We performed a case notes review of patients who had facial nerve repair over a 10-year period and had completed 24 months of follow-up. Results: The study population comprised 18 female patients and 24 male patients, with an overall mean age of 53.2 years (range, 16 to 80 years). Of the 24 patients who had a cable nerve graft, the greater auricular nerve was used in 15 cases. The sural nerve was used as the donor in a cross-facial nerve graft in 9 patients. Sixteen patients had transposition nerve repair: hypoglossal and ansa cervicalis in 7 and 9 cases, respectively. Two patients had primary anastomosis after surgery for extensive malignant tumors. In this series, no patients achieved a House-Brackmann (HB) grade of II. Overall, the HB grades III, IV, and V were the best postoperative facial nerve functions achieved in 11.9%, 33.3%, and 26.2% of patients, respectively. Failure (HB grade VI) was observed in 28.6% of patients. More than half of patients (62.5%) who had either a sural nerve cable graft or a faciohypoglossal transposition had a good outcome (HB grade III or IV). Conclusions: In the present series, 45% of patients had an HB grade of HI or IV at long-term follow-up. The best outcome (HB grade III) was observed after cross-facial grafting with the sural nerve. C1 [Leong, Samuel C.; Lesser, Tristram H.] Aintree Univ Hosp NHS Fdn Trust, Dept Otorhinolaryngol Head & Neck Surg, Skull Base Unit, Liverpool L9 7AL, Merseyside, England. RP Leong, SC (reprint author), Aintree Univ Hosp NHS Fdn Trust, Dept Otorhinolaryngol Head & Neck Surg, Liverpool L9 7AL, Merseyside, England. CR Bianchi B, 2012, CURR OPIN OTOLARYNGO, V20, P114, DOI 10.1097/MOO.0b013e32834fa744 Brown PD, 2000, INT J RADIAT ONCOL, V48, P737, DOI 10.1016/S0360-3016(00)00721-5 Eaton DA, 2007, AM J OTOLARYNG, V28, P37, DOI 10.1016/j.amjoto.2006.06.009 Gidley PW, 2010, LARYNGOSCOPE, V120, P1985, DOI 10.1002/lary.21048 GULLANE PJ, 1987, J OTOLARYNGOL, V16, P112 Guntinas-Lichius O, 2007, LARYNGOSCOPE, V117, P421, DOI 10.1097/MLG.0b013e31802d83df Iseli TA, 2010, LARYNGOSCOPE, V120, P478, DOI 10.1002/lary.20789 KUKWA A, 1994, BRIT J NEUROSURG, V8, P327, DOI 10.3109/02688699409029621 Malik TH, 2005, OTOL NEUROTOL, V26, P284, DOI 10.1097/00129492-200503000-00028 MCGUIRT WF, 1989, LARYNGOSCOPE, V99, P27 MCGUIRT WF, 1977, LARYNGOSCOPE, V87, P415, DOI 10.1288/00005537-197703000-00015 Nitzan D, 2004, PLAST RECONSTR SURG, V114, P1060, DOI 10.1097/01.prs.0000135326.50939.c1 Ozmen OA, 2011, OTOL NEUROTOL, V32, P1341, DOI 10.1097/MAO.0b013e31822e952d PILLSBURY HC, 1979, ARCH OTOLARYNGOL, V105, P441 Reddy PG, 1999, LARYNGOSCOPE, V109, P894, DOI 10.1097/00005537-199906000-00010 Romeo M, 2012, CLIN OTOLARYNGOL, V37, P181, DOI 10.1111/j.1749-4486.2012.02484.x Schipper J, 2005, CHIRURG, V76, P47, DOI 10.1007/s00104-004-0883-z Yetiser S, 2007, ANN OTO RHINOL LARYN, V116, P542 NR 18 TC 0 Z9 0 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD NOV PY 2013 VL 122 IS 11 BP 695 EP 700 PG 6 WC Otorhinolaryngology SC Otorhinolaryngology GA 264XZ UT WOS:000327915600006 PM 24358630 ER PT J AU Izuhara, K Wada, K Nakamura, K Tamai, Y Tsuji, M Ito, Y Nagata, C AF Izuhara, Keiichi Wada, Keiko Nakamura, Kozue Tamai, Yuya Tsuji, Michiko Ito, Yatsuji Nagata, Chisato TI Association Between Tinnitus and Sleep Disorders in the General Japanese Population SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE epidemiology; insomnia; Japan; population-based study; sleep disorder; tinnitus ID COGNITIVE-BEHAVIORAL THERAPY; COMMUNITY; QUALITY; PREVALENCE; INSOMNIA; NOISE AB Objectives: There are few studies about the association between tinnitus and sleep disorders in the general population worldwide. This study assessed this association in a Japanese community. Methods: A total of 14,027 participants 45 to 79 years of age who were in. the Takayama Study responded to a self-administered questionnaire about tinnitus and sleep disorders. Results: Of this population, 13.3% of men and 10.6% of women had current tinnitus. The percentages of insomnia, respectively, among individuals with and without tinnitus were 28.1% in men and 36.1% in women and 18.8% in men and 21.5% in women. There were 1.7-fold (95% confidence interval [CI], 1.4 to 2.1) and 1.8-fold (95% CI, 1.5 to 2.2) increases in the odds ratios (ORs) of insomnia for those with tinnitus compared with those without tinnitus in men and women, respectively. Loud or very loud tinnitus was associated with 2.8-fold (95% CI, 1.8 to 4.3) and 3.3-fold (95% CI, 1.9 to 5.6) increases in the OR of insomnia in men and women, respectively. Even low (ie, quiet) or moderate tinnitus was significantly associated with insomnia. Difficulty initiating sleep, difficulty maintaining sleep, and a poor perceived quality of sleep were also significantly associated with tinnitus. Conclusions: Insomnia and other sleep disorders were significantly associated with tinnitus in Japanese adults. C1 [Izuhara, Keiichi; Ito, Yatsuji] Gifu Univ, Grad Sch Med, Dept Otolaryngol, Gifu 5011193, Japan. [Wada, Keiko; Nakamura, Kozue; Tamai, Yuya; Tsuji, Michiko; Nagata, Chisato] Gifu Univ, Grad Sch Med, Dept Epidemiol & Prevent Med, Gifu 5011193, Japan. RP Izuhara, K (reprint author), Gifu Univ, Grad Sch Med, Dept Otolaryngol, 1-1 Yanagido, Gifu 5011193, Japan. CR ALSTER J, 1993, BIOL PSYCHIAT, V34, P84, DOI 10.1016/0006-3223(93)90260-K Andersson G, 2002, CLIN PSYCHOL REV, V22, P977, DOI 10.1016/S0272-7358(01)00124-6 Asplund R, 2003, ARCH GERONTOL GERIAT, V37, P139, DOI 10.1016/S0167-4943(03)00028-1 AXELSSON A, 1989, British Journal of Audiology, V23, P53, DOI 10.3109/03005368909077819 BUYSSE DJ, 1989, PSYCHIAT RES, V28, P193, DOI 10.1016/0165-1781(89)90047-4 Coles R R, 1984, J Laryngol Otol Suppl, V9, P7 Doi Y, 1998, JAPANESE J PSYCHIAT, V13, P755 Doi Y, 2000, J Epidemiol, V10, P79 Elgoyhen AB, 2011, TEXTBOOK OF TINNITUS, P625, DOI 10.1007/978-1-60761-145-5_78 ERLANDSSON SI, 1992, AUDIOLOGY, V31, P168 Ferreira Lidiane Maria de Brito Macedo, 2009, Braz J Otorhinolaryngol, V75, P249 Folmer R. L., 2002, BMC EAR NOSE THROAT, V2, P3, DOI DOI 10.1186/1472-6815-2-3 Folmer RL, 2000, AM J OTOLARYNG, V21, P287, DOI 10.1053/ajot.2000.9871 Fujii K, 2011, J EPIDEMIOL, V21, P299, DOI 10.2188/jea.JE20100124 Hebert S, 2007, EAR HEARING, V28, P649 HELLER MF, 1953, ANN OTO RHINOL LARYN, V62, P73 Henry James A, 2008, Trends Amplif, V12, P188, DOI 10.1177/1084713808321184 Jakovljevic B, 2006, CROAT MED J, V47, P125 Khedr EM, 2010, NEUROEPIDEMIOLOGY, V35, P45, DOI 10.1159/000306630 KRONERHERWIG B, 1995, J PSYCHOSOM RES, V39, P153, DOI 10.1016/0022-3999(94)00098-P Lasisi AO, 2011, ANN OTO RHINOL LARYN, V120, P226 McKenna L., 2006, TINNITUS TREATMENT C, P81 Nagata C, 2002, AM J EPIDEMIOL, V156, P824, DOI 10.1093/aje/kwf118 Sadlier M, 2008, J LARYNGOL OTOL, V122, P31, DOI 10.1017/S0022215107007438 Sanchez L, 1997, EAR HEARING, V18, P210, DOI 10.1097/00003446-199706000-00004 Shimizu H., 1996, BASIC REPORT TAKAYAM Test T, 2011, SLEEP, V34, P25 TYLER RS, 1983, J SPEECH HEAR DISORD, V48, P150 Tyler RS, 2007, PROG BRAIN RES, V166, P425, DOI 10.1016/S0079-6123(07)66041-5 NR 29 TC 2 Z9 2 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD NOV PY 2013 VL 122 IS 11 BP 701 EP 706 PG 6 WC Otorhinolaryngology SC Otorhinolaryngology GA 264XZ UT WOS:000327915600007 PM 24358631 ER PT J AU Bryans, L Palmer, AD Schindler, JS Andersen, PE Cohen, JI AF Bryans, Linda Palmer, Andrew D. Schindler, Joshua S. Andersen, Peter E. Cohen, James I. TI Subjective and Objective Parameters of the Adult Female Voice After Cricotracheal Resection and Dilation SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE cricotracheal resection; dilatation; laryngotracheal stenosis; subglottic stenosis; voice; voice disorder ID IDIOPATHIC LARYNGOTRACHEAL STENOSIS; THYROTRACHEAL ANASTOMOSIS; SUBGLOTTIC STENOSIS; RECONSTRUCTION; LARYNGEAL; OUTCOMES; AIRWAY AB Objectives: We compared the voice outcomes after cricotracheal resection (CTR) and airway dilation in adult women. Methods: We performed long-term comprehensive voice assessments in 23 adult women treated for laryngotracheal stenosis, including acoustic and perceptual measurements of voice, videostroboscopy, the Voice Handicap Index, and an open-ended subjective questionnaire. Results: Voice measures were abnormal in both groups. Objective pitch and loudness measurements were significantly more impaired after CTR than after dilation. Perceptual ratings of voice were worse after CTR than after dilation, particularly with regard to breathiness, pitch, and loudness. The CTR group was more likely to report a voice disorder, reported significantly more voice symptoms, and had higher voice handicap scores. Videostroboscopy was frequently abnormal in both groups, with more evidence of vocal hyperfunction after CTR. Self-ratings of breathing and swallowing were generally high in both groups, but voice satisfaction was rated lower after CTR. Conclusions: Voice was more significantly negatively impacted by CTR than by dilation. Surprisingly, many individuals in both groups reported improvements - a finding that possibly highlights the impact of laryngotracheal stenosis on airflow and vocal function before surgery. The importance of patient selection and preoperative counseling is emphasized, along with the potential need for voice therapy. C1 [Bryans, Linda; Palmer, Andrew D.; Schindler, Joshua S.; Andersen, Peter E.; Cohen, James I.] Oregon Hlth & Sci Univ, Dept Otolaryngol Head & Neck Surg, Portland, OR 97239 USA. [Bryans, Linda; Palmer, Andrew D.; Schindler, Joshua S.] Oregon Hlth & Sci Univ, Northwest Clin Voice & Swallowing, Portland, OR 97239 USA. RP Bryans, L (reprint author), Oregon Hlth & Sci Univ, Dept Otolaryngol Head & Neck Surg, NW Clin Voice & Swallowing, 3181 SW Sam Jackson Pk Rd, Portland, OR 97239 USA. CR Alvarez-Neri H, 2005, ANN OTO RHINOL LARYN, V114, P2 Ashiku SK, 2004, J THORAC CARDIOV SUR, V127, P99, DOI 10.1016/j.jtcvs.2002.11.001 COURAUD L, 1995, ANN THORAC SURG, V60, P250, DOI 10.1016/0003-4975(95)00464-V Darley F.L, 1975, MOTOR SPEECH DISORDE Ettema SL, 2006, OTOLARYNG HEAD NECK, V135, P730, DOI 10.1016/j.otohns.2006.06.1249 Grillo HC, 2003, ANN OTO RHINOL LARYN, V112, P798 GRILLO HC, 1982, ANN THORAC SURG, V33, P3 Hirano M, 1993, VIDEOSTROBOSCOPIC EX Houlton JJ, 2011, LARYNGOSCOPE, V121, P1910, DOI 10.1002/lary.21915 Jacobson BH, 1997, AM J SPEECH-LANG PAT, V6, P66 Karnell MP, 2007, J VOICE, V21, P576, DOI 10.1016/j.jvoice.2006.05.001 Kempster GB, 2009, AM J SPEECH-LANG PAT, V18, P124, DOI 10.1044/1058-0360(2008/08-0017) Laukkanen AM, 2009, FOLIA PHONIATR LOGO, V61, P57, DOI 10.1159/000201000 Lehto Laura, 2006, Logoped Phoniatr Vocol, V31, P147, DOI 10.1080/14015430600654654 WEWERS ME, 1990, RES NURS HEALTH, V13, P227, DOI 10.1002/nur.4770130405 MADDAUS MA, 1992, J THORAC CARDIOV SUR, V104, P1443 PEARSON FG, 1986, ANN OTO RHINOL LARYN, V95, P582 Pett M. A., 1997, NONPARAMETRIC STAT H Sauder C, 2010, ANN OTO RHINOL LARYN, V119, P460 Smith ME, 2008, ANN OTO RHINOL LARYN, V117, P85 van den Boogert J, 2004, HEAD NECK-J SCI SPEC, V26, P111, DOI 10.1002/hed.10364 Wolf M, 2001, LARYNGOSCOPE, V111, P622, DOI 10.1097/00005537-200104000-00012 NR 22 TC 2 Z9 2 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD NOV PY 2013 VL 122 IS 11 BP 707 EP 716 PG 10 WC Otorhinolaryngology SC Otorhinolaryngology GA 264XZ UT WOS:000327915600008 PM 24358632 ER PT J AU Schindler, A Mozzanica, F Monzani, A Ceriani, E Atac, M Jukic-Peladic, N Venturini, C Orlandoni, P AF Schindler, Antonio Mozzanica, Francesco Monzani, Anna Ceriani, Eleonora Atac, Murat Jukic-Peladic, Nikolina Venturini, Claudia Orlandoni, Paolo TI Reliability and Validity of the Italian Eating Assessment Tool SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE dysphagia; outcome; reliability; self-assessment; validity ID SWAL-QOL; OROPHARYNGEAL DYSPHAGIA; OUTCOMES TOOL; ACUTE STROKE; PREVALENCE; POPULATION; DISORDERS; SEVERITY; ADULTS; IMPACT AB Objectives: We sought to evaluate the reliability and validity of the Italian EAT-10 (Italian Eating Assessment Tool; I-EAT-10). Methods: The study consisted of 4 phases: item generation, internal consistency and reliability analysis, normative data generation, and validity analysis. Discussion of the EAT-10. with 30 patients and its back-translation were accomplished. The recruited population included 172 patients (40 with dysphonia and 132 with dysphagia) and 269 asymptomatic subjects for testing of internal consistency, and 94 patients with dysphagia and 158 asymptomatic subjects for test-retest reliability analysis. Normative data were gathered from the 269 subjects. The scores of patients and asymptomatic subjects were compared. The I-EAT-10 and flexible endoscopic evaluation of swallowing (FEES) scores in 94 patients were correlated. The I-EAT-10 scores made before and after successful swallowing rehabilitation in 38 patients were compared. Results: Excellent internal consistency (Cronbach's alpha values of 0.90 and 0.93) and strong test-retest reliability (intraclass correlation coefficients of 0.95 and 0.98) were found in patients and asymptomatic subjects. The I-EAT-10 mean (+/-SD) score of the normal cohort was 0.6 +/- 1.1. The asymptomatic subjects and dysphonic patients scored lower than the dysphagic patients on the Kruskal-Wallis test (p = 0.001). The I-EAT-10 and FEES scores were mildly correlated. The mean I-EAT-10 score improved from 9.8 +/- 10.3 to 5.8 +/- 6.7 after swallowing rehabilitation (p = 0.04). Conclusions: The I-EAT-10 is a reliable, valid, symptom-specific outcome tool. C1 [Schindler, Antonio; Mozzanica, Francesco; Monzani, Anna; Ceriani, Eleonora; Atac, Murat] Univ Milan, L Sacco Dept Biomed & Clin Sci, Milan, Italy. [Schindler, Antonio] GISD, Milan, Italy. [Venturini, Claudia; Orlandoni, Paolo] Soc Italiana Nutr Artificiale & Metab SINPE, Milan, Italy. [Jukic-Peladic, Nikolina; Venturini, Claudia; Orlandoni, Paolo] INRCA IRCCS, Unit Nutr Therapy, Ancona, Italy. RP Schindler, A (reprint author), Osped L Sacco, Via GB Grassi 74, I-20157 Milan, Italy. EM antonio.schindler@unimi.it CR Belafsky PC, 2008, ANN OTO RHINOL LARYN, V117, P919 BLOEM BR, 1990, BRIT MED J, V300, P721 Chen AY, 2001, ARCH OTOLARYNGOL, V127, P870 Coates C, 1997, EUR NEUROL, V38, P49, DOI 10.1159/000112902 Ekberg O, 2002, DYSPHAGIA, V17, P139, DOI 10.1007/s00455-001-0113-5 Eslick GD, 2003, ALIMENT PHARM THERAP, V17, P1115, DOI 10.1046/j.0269-2813.2003.01557.x Farneti D, 2008, ACTA OTORHINOLARYNGO, V28, P135 GUILLEMIN F, 1993, J CLIN EPIDEMIOL, V46, P1417, DOI 10.1016/0895-4356(93)90142-N KJELLEN G, 1981, CLIN PHYSIOL, V1, P405, DOI 10.1111/j.1475-097X.1981.tb00908.x LINDGREN S, 1991, Dysphagia, V6, P187, DOI 10.1007/BF02493524 Mann G, 2000, CEREBROVASC DIS, V10, P380, DOI 10.1159/000016094 McHorney CA, 2002, DYSPHAGIA, V17, P97, DOI 10.1007/s00455-001-0109-1 McHorney CA, 2006, DYSPHAGIA, V21, P141, DOI 10.1007/s00455-005-0026-9 McHorney CA, 2000, DYSPHAGIA, V15, P122 O'Neil KH, 1999, DYSPHAGIA, V14, P139, DOI 10.1007/PL00009595 Rosenbek JC, 1996, DYSPHAGIA, V11, P93, DOI 10.1007/BF00417897 Schindler A, 2008, Rev Laryngol Otol Rhinol (Bord), V129, P97 Smithard DG, 1996, STROKE, V27, P1200 TALLEY NJ, 1992, AM J EPIDEMIOL, V136, P165 Wallace Karen L., 2000, Gastroenterology, V118, P678, DOI 10.1016/S0016-5085(00)70137-5 Wilkins T, 2007, J AM BOARD FAM MED, V20, P144, DOI 10.3122/jabfm.2007.02.060045 NR 21 TC 1 Z9 1 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD NOV PY 2013 VL 122 IS 11 BP 717 EP 724 PG 8 WC Otorhinolaryngology SC Otorhinolaryngology GA 264XZ UT WOS:000327915600009 PM 24358633 ER PT J AU Bocciolini, C Fornelli, A Casadei, GP Cattani, MG Dall'Olio, D AF Bocciolini, Corso Fornelli, Adele Casadei, Gian Piero Cattani, Maria Grazia Dall'Olio, Danilo TI PEComa of the Nasal Cavity With Worrisome Histologic Features and Benign Behavior: A Case Report SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE differential diagnosis; malignant histology; nasal cavity; PEComa ID CELL; TUMOR; ANGIOMYOLIPOMA; LESIONS; FAMILY AB Objectives: PEComas (perivascular epithelioid cell tumors) are a family of neoplastic lesions that share overlapping ultrastructure and morphological and immunohistochemical appearance and include angiomyolipoma, lymphangioleiomyomatosis, and clear cell "sugar" tumor of the lung, as well as similar tumors that occur in a variety of visceral, cutaneous, and soft tissue sites throughout the body. Methods: A 40-year-old woman came to medical attention because of epistaxis and because of unilateral nasal obstruction of 3 months' duration. Endoscopic examination revealed a well-demarcated exophytic lesion attached to the anterior portion of the middle turbinate. Results: The lesion was superficially located, and therefore amenable to complete surgical excision. Seven years after surgery, the patient is alive and well, without evidence of local recurrence or metastastic disease. Based on morphological and immunohistochemical appearance, a diagnosis of PEComa with worrisome histologic features was rendered. Conclusions: In the present study, we describe a PEComa that occurred in the nasal cavity and discuss the behavior of this entity. The importance of recognizing this disease will ensure its consideration in the differential diagnosis of tumors of the head that have similar morphological features. The histogenesis of PEComa still remains elusive, and collection of additional cases with a prolonged follow-up will be important in accurately determining the behavior of these distinctive tumors. C1 [Bocciolini, Corso; Dall'Olio, Danilo] Maggiore Hosp, Inst Otorhinolaryngol, Dept Surg, I-40133 Bologna, Italy. [Fornelli, Adele; Casadei, Gian Piero] Maggiore Hosp, Inst Pathol, Dept Oncol, I-40133 Bologna, Italy. [Cattani, Maria Grazia] Bellaria Hosp, Dept Oncol, Inst Pathol, Bologna, Italy. RP Bocciolini, C (reprint author), Maggiore Hosp, Inst Otorhinolaryngol, Largo Nigrisoli 2, I-40133 Bologna, Italy. CR Bandhlish Anshu, 2011, Head Neck Pathol, V5, P233, DOI 10.1007/s12105-011-0268-9 Banerjee SS, 2001, INT J SURG PATHOL, V9, P309, DOI 10.1177/106689690100900410 BONETTI F, 1994, PATHOLOGY, V26, P230 Elder DE, 2010, MELANOCYTIC TUMORS S Folpe AL, 2005, AM J SURG PATHOL, V29, P1558, DOI 10.1097/01.pas.0000173232.22117.37 Gana S, 2012, ACTA OTORHINOLARYNGO, V32, P198 Hornick JL, 2006, HISTOPATHOLOGY, V48, P75, DOI 10.1111/j.1365-2559.2005.02316.x Kuroda N, 2009, PATHOL INT, V59, P769, DOI 10.1111/j.1440-1827.2009.02443.x Liegl B, 2008, AM J SURG PATHOL, V32, P608, DOI 10.1097/PAS.0b013e31815604ab Mentzel T, 2005, HISTOPATHOLOGY, V46, P498, DOI 10.1111/j.1365-2559.2005.02105.x Panelos J, 2009, OTOLARYNG HEAD NECK, V141, P543, DOI 10.1016/j.otohns.2009.03.009 Rosai J, 2011, ROSAI ACKERMANS SURG, V10th Yamashita K, 2010, AM J SURG PATHOL, V34, P1622, DOI 10.1097/PAS.0b013e3181f5974f NR 13 TC 0 Z9 0 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD NOV PY 2013 VL 122 IS 11 BP 725 EP 728 PG 4 WC Otorhinolaryngology SC Otorhinolaryngology GA 264XZ UT WOS:000327915600010 PM 24358634 ER PT J AU Collins, B Powitzky, R Enix, J Digoy, P AF Collins, Benjamin Powitzky, Rosser Enix, Jessica Digoy, Paul TI Congenital Nasal Pyriform Aperture Stenosis: Conservative Management SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE nasal steroid; pyriform aperture stenosis ID DIAGNOSIS AB Objectives: This case series outlines the advantages of using 0.1% intranasal dexamethasone drops (IDD) to treat nasal obstruction in patients with congenital pyriform aperture stenosis (PAS). Methods: Five consecutive cases of PAS were reviewed. Results: Three patients were treated with IDD alone, and 2 were treated surgically and had residual postoperative nasal obstruction before IDD. Four patients in follow-up (mean, 1 year) were weaned off the steroid drops with good breathing results. One patient developed iatrogenic Cushing's disease, and another, who was initially treated with surgery, eventually required nasal vestibular stenosis repair in addition to IDD. Conclusions: This study is the first to review the use of IDD in treating PAS. The potential impact of midnasal stenosis is discussed, and a conservative management algorithm for patients with PAS is presented. Careful surveillance for potential side effects of IDD is recommended, especially in cases that require elevated doses. C1 [Collins, Benjamin; Powitzky, Rosser; Enix, Jessica; Digoy, Paul] Univ Oklahoma, Hlth Sci Ctr, Dept Otorhinolaryngol, Oklahoma City, OK 73126 USA. RP Digoy, P (reprint author), Univ Oklahoma, Hlth Sci Ctr, Dept Otorhinolaryngol, POB 26901 WP 1290, Oklahoma City, OK 73126 USA. CR Belden CJ, 1999, RADIOLOGY, V213, P495 Bharti G, 2011, J CRANIOFAC SURG, V22, P992, DOI 10.1097/SCS.0b013e31821016b7 BROWN OE, 1989, LARYNGOSCOPE, V99, P86 Contencin P, 1999, ARCH OTOLARYNGOL, V125, P777 De Mot P, 2004, AM J RHINOL, V18, P179 Devambez M, 2009, CLEFT PALATE-CRAN J, V46, P262, DOI 10.1597/07-182.1 Losken A, 2002, PLAST RECONSTR SURG, V109, P1506, DOI 10.1097/00006534-200204150-00003 Shikowitz MJ, 2003, INT J PEDIATR OTORHI, V67, P635, DOI 10.1016/S0165-5876(03)00018-1 Tate JR, 2009, OTOLARYNG CLIN N AM, V42, P521, DOI 10.1016/j.otc.2009.03.006 TAVIN E, 1994, INT J PEDIATR OTORHI, V28, P199, DOI 10.1016/0165-5876(94)90012-4 Van den Abbeele T, 2001, ANN OTO RHINOL LARYN, V110, P70 NR 11 TC 0 Z9 0 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD OCT PY 2013 VL 122 IS 10 BP 601 EP 604 PG 4 WC Otorhinolaryngology SC Otorhinolaryngology GA 239ZG UT WOS:000326063900001 PM 24294681 ER PT J AU Colletti, L Wilkinson, EP Colletti, V AF Colletti, Liliana Wilkinson, Eric P. Colletti, Vittorio TI Auditory Brainstem Implantation After Unsuccessful Cochlear Implantation of Children With Clinical Diagnosis of Cochlear Nerve Deficiency SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE auditory brainstem implant; cochlear implant; cochlear nerve absence; cochlear nerve deficiency; inner ear malformation ID NEUROPATHY SPECTRUM DISORDER; INNER-EAR MALFORMATIONS; DEAF-CHILDREN; HEARING-LOSS; OUTCOMES; YOUNGER; PERFORMANCE; NUCLEUS; AGE AB Objectives: We compared the perceptual auditory abilities of 21 children with suspected cochlear nerve deficiency (CND) and a surgically verified absent cochlear nerve (CN) who first underwent cochlear implantation (CI) and subsequently underwent auditory brainstem implantation (ABI). Methods: In this retrospective cohort study, from 2000 to 2011, 21 children initially underwent CI at an outside institution and failed to progress in their perceptual auditory abilities. Before CI, all of the children had severe to profound sensorineural hearing loss and a diagnosis of CND. Magnetic resonance imaging (MRI) documented an absent CN in 13 children and a small CN in 8 children. We performed explantation of the cochlear implant and simultaneous ABI on the same side. We performed MRI if no previous MRI results were available. All surgical videos were reviewed to determine the presence or absence of the CN. Measures of the patients' perceptual auditory abilities obtained after CI and after ABI were converted to the Category of Auditory Performance (CAP) scale. Results: At surgery, all patients demonstrated an absent CN. After CI, all patients had a CAP score of 2 or less (mean, 0.52 +/- 0.68). After ABI, all patients had a CAP score of 2 or more (mean, 4.33 +/- 1.68); the improvement was statistically significant (p < 0.001). The complication rates were similar for Cl and ABI. Conclusions: In this cohort of patients who had poor performance after CI, ABI achieved significantly improved performance as measured by the CAP and was shown to successfully rehabilitate hearing. Cases of a small CN may in reality represent an absent CN. Although this cohort was selected from patients with failed CI, the results have implications for the selection of device for patients with CND, in that ABI is a potential alternative to CI in select cases. In patients who fail to progress with intensive rehabilitation with CI or who have no progression in evoked auditory brainstem response, ABI must be considered early. C1 [Colletti, Liliana; Colletti, Vittorio] Univ Verona, Dept Otorhinolaryngol, I-37100 Verona, Italy. [Wilkinson, Eric P.] House Clin, Los Angeles, CA USA. [Wilkinson, Eric P.] House Res Inst, Los Angeles, CA USA. RP Colletti, L (reprint author), Univ Verona, Dept Otorhinolaryngol, Piazzale LA Scuro 10, I-37100 Verona, Italy. CR Adunka OF, 2006, OTOL NEUROTOL, V27, P793, DOI 10.1097/01.mao.0000227895.34915.94 Adunka OF, 2007, OTOL NEUROTOL, V28, P597, DOI 10.1097/01.mao.0000281804.36574.72 Archbold S, 1998, BRIT J AUDIOL, V32, P7, DOI 10.3109/03005364000000045 Archbold S., 1995, Annals of Otology Rhinology and Laryngology, V104, P312 Breneman AI, 2012, J AM ACAD AUDIOL, V23, P5, DOI 10.3766/jaaa.23.1.2 Buchman CA, 2011, LARYNGOSCOPE, V121, P1979, DOI 10.1002/lary.22032 Buchman CA, 2006, EAR HEARING, V27, P399, DOI 10.1097/01.aud.0000224100.30525.ab Casselman JW, 1997, RADIOLOGE, V37, P954, DOI 10.1007/s001170050307 Cervera-Paz FJ, 2007, ACTA NEUROCHIR SUPPL, V97, P437 Choi JY, 2011, LARYNGOSCOPE, V121, P2610, DOI 10.1002/lary.22137 Colletti L, 2008, LARYNGOSCOPE, V118, P1443, DOI [10.1097/MLG.0b013e318173a011, 10.1097/MLG.0b03e318173a011] Colletti L, 2012, OTOLARYNG HEAD NECK, V147, P139, DOI 10.1177/0194599812441572 Colletti V, 2010, OTOL NEUROTOL, V31, P558, DOI 10.1097/MAO.0b013e3181db7055 Colletti V, 2004, ACTA OTO-LARYNGOL, V124, P353, DOI 10.1080/00016480410016441 Colletti V, 2005, AS C JUL 30 AUG 4 PA Dettman SJ, 2007, EAR HEARING, V28, p11S, DOI 10.1097/AUD.0b013e31803153f8 Eisenberg LS, 2008, OTOL NEUROTOL, V29, P251 Eisenberg LS, 2012, J AM ACAD AUDIOL, V23, P412, DOI 10.3766/jaaa.23.6.4 Goffi-Gomez MVS, 2012, INT J PEDIATR OTORHI, V76, P257, DOI 10.1016/j.ijporl.2011.11.016 Gordon Karen A, 2002, Ann Otol Rhinol Laryngol Suppl, V189, P42 Grayeli AB, 2003, OTOL NEUROTOL, V24, P79, DOI 10.1097/00129492-200301000-00016 Kim AH, 2008, OTOL NEUROTOL, V29, P626, DOI 10.1097/MAO.0b013e31817781f5 Kirk KI, 2002, ANN OTO RHINOL LARYN, V111, P69 Manrique M, 2004, LARYNGOSCOPE, V114, P1462, DOI 10.1097/00005537-200408000-00027 MOORE JK, 1994, AM J OTOL, V15, P588 Nikolopoulos TP, 2000, EAR HEARING, V21, P236, DOI 10.1097/00003446-200006000-00007 O'Driscoll M, 2011, EAR HEARING, V32, P286, DOI 10.1097/AUD.0b013e3181fc9d72 Ozdogmus O, 2004, J ANAT, V205, P65, DOI 10.1111/j.0021-8782.2004.00313.x Ponton CW, 1996, NEUROREPORT, V8, P61, DOI 10.1097/00001756-199612200-00013 Sennaroglu L, 2009, OTOL NEUROTOL, V30, P708, DOI 10.1097/MAO.0b013e3181b07d41 Sharma A, 2009, J COMMUN DISORD, V42, P272, DOI 10.1016/j.jcomdis.2009.03.003 Song MH, 2010, LARYNGOSCOPE, V120, P1625, DOI 10.1002/lary.21008 Stjernholm C, 2002, ACTA OTO-LARYNGOL, V122, P43, DOI 10.1080/00016480252775724 Teagle HFB, 2010, EAR HEARING, V31, P325, DOI 10.1097/AUD.0b013e3181ce693b Thai-Van H, 2000, Am J Otol, V21, P663 Walton J, 2008, OTOL NEUROTOL, V29, P302, DOI 10.1097/MAO.0b013e318164d0f6 Waltzman SB, 2005, PEDIATRICS, V116, pE487, DOI 10.1542/peds.2005-0282 Zanetti D, 2006, OTOL NEUROTOL, V27, P815, DOI 10.1097/01.mao.0000227899.80656.1d NR 38 TC 5 Z9 5 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD OCT PY 2013 VL 122 IS 10 BP 605 EP 612 PG 8 WC Otorhinolaryngology SC Otorhinolaryngology GA 239ZG UT WOS:000326063900002 PM 24294682 ER PT J AU Neumann, C Yung, J Carroll, PH AF Neumann, Codruta Yung, Jennifer Carroll, Paul H. TI Mastoid Surgery Under Local Anesthesia for Medically Unfit Patients: Techniques and Outcome SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE cholesteatoma; local anesthetic; mastoid surgery ID SUPPURATIVE OTITIS-MEDIA; QUALITY-OF-LIFE AB Objectives: We present the surgical techniques and outcomes of mastoid surgery under local anesthesia in patients who were unfit for general anesthesia. Methods: Five tertiary-referred patients with multiple comorbidities and failed conservative treatment for chronic otitis media were operated on under local anesthesia. No sedation was administered. The principles of cholesteatoma surgery were observed, but the technique was adapted to keep surgical time to a minimum. Results: None of the patients had perioperative problems, and all have dry, waterproof ears with preservation of hearing after surgery. So far, none of the patients have had recurrent or residual disease. Conclusions: Cholesteatoma surgery can be successfully performed with a local anesthetic in patients who are medically unfit for general anesthesia. Surgery requires a good coordination of the operating team in order to shorten the operating time. Otologists should develop and maintain their skills by performing ear surgery with local anesthetic on a regular basis. C1 [Neumann, Codruta] Ipswich Hosp, Dept Otolaryngol, Ipswich 1P4 5PD, Suffolk, England. [Carroll, Paul H.] Ipswich Hosp, Dept Anaesthesia, Ipswich 1P4 5PD, Suffolk, England. [Yung, Jennifer] Univ Manchester, Sch Med, Manchester, Lancs, England. RP Neumann, C (reprint author), Ipswich Hosp, ENT Dept, Heath Rd, Ipswich 1P4 5PD, Suffolk, England. CR Bakir S, 2013, EUR ARCH OTO-RHINO-L, V270, P521, DOI 10.1007/s00405-012-2031-6 Baumann I, 2011, HEALTH QUAL LIFE OUT, V9, DOI 10.1186/1477-7525-9-48 Graham H B, 1922, Cal State J Med, V20, P130 Ibrahim SI, 2010, J LARYNGOL OTOL, V124, P1158, DOI 10.1017/S0022215110000976 SMITH MFW, 1986, ANN OTO RHINOL LARYN, V95, P1 Yung MW, 1996, CLIN OTOLARYNGOL, V21, P404, DOI 10.1046/j.1365-2273.1996.00814.x NR 6 TC 0 Z9 0 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD OCT PY 2013 VL 122 IS 10 BP 613 EP 618 PG 6 WC Otorhinolaryngology SC Otorhinolaryngology GA 239ZG UT WOS:000326063900003 PM 24294683 ER PT J AU Leong, SC Narayan, S Lesser, TH AF Leong, Samuel C. Narayan, Surya Lesser, Tristram H. TI Antisecretory Factor Inducing Therapy Improves Patient-Reported Functional Levels in Meniere's Disease SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE antisecretory factor; cereal; endolymphatic hydrops; Meniere's disease ID FOOD AB Objectives: The aim of this study was to evaluate the effectiveness of specially processed cereal (SPC) as a suitable adjunctive treatment for Meniere's disease. Methods: We performed a randomized double-blinded, placebo-controlled, crossover study in a tertiary referral center of patients who had a diagnosis of Meniere's disease based on the guidelines of the Committee on Hearing and Equilibrium of the American Academy of Otolaryngology Head and Neck Surgery (AAO-HNS). The main outcome measure was the AAO-HNS Functional Level Scale (FLS). Results: Thirty-nine patients completed the study without any reported complications. The mean pretreatment FLS score for the entire study cohort was 3.8 (median, 4; range, 1 to 6). The overall FLS score improved significantly (p < 0.001), to 2.8 (median, 3), after SPC treatment. No patients showed worsening on the FLS during SPC or placebo treatment. Of the 39 patients, 23 showed improvement on the FLS, and no change was observed in the remaining 16. The median improvement on the FLS in these 23 patients was 2 points (mean, 1.7; range, 1 to 4). The mean FLS score after placebo cereal treatment was not significantly different from baseline (p = 0.452), but was significantly higher than that after SPC treatment (mean, 3.7; p < 0.001). The marginal difference observed between the baseline FLS score and the placebo FLS score was due to the fact that 5 patients reported 1-point improvements on the FLS after placebo treatment. Nevertheless, significantly fewer patients improved on placebo than on SPC (p < 0.001). Conclusions: Treatment with SPC appears to be well tolerated by most patients (91%) without any complications. More than half (59%) of the study cohort reported subjective improvement in functional level. C1 [Leong, Samuel C.; Lesser, Tristram H.] Aintree Univ Hosp NHS Fdn Trust, Dept Otorhinolaryngol Head & Neck Surg, Skull Base Unit, Liverpool L9 7AL, Merseyside, England. [Narayan, Surya] Royal Blackburn Hosp, Dept Otorhinolaryngol, Blackburn, Lancs, England. RP Leong, SC (reprint author), Aintree Univ Hosp NHS Fdn Trust, Dept Otorhinolaryngol Head & Neck Surg, Liverpool L9 7AL, Merseyside, England. CR [Anonymous], 1995, OTOLARYNGOL HEAD NEC, V113, P181 BAGGERSJOBACK D, 1986, AM J OTOL, V7, P134 Bjorck S, 2000, GUT, V46, P824, DOI 10.1136/gut.46.6.824 Gibson WPR, 1997, OTOLARYNG CLIN N AM, V30, P961 Hanner P, 2010, ACTA OTO-LARYNGOL, V130, P223, DOI 10.3109/00016480903022842 Hanner P, 2004, HEARING RES, V190, P31, DOI 10.1016/S0378-5955(03)00368-X LANGE S, 1994, BRIT POULTRY SCI, V35, P615, DOI 10.1080/00071669408417726 Syed I, 2012, INT J CLIN PRACT, V66, P166, DOI 10.1111/j.1742-1241.2011.02842.x Ulgheri C, 2010, NUTR RES REV, V23, P300, DOI 10.1017/S0954422410000193 Zaman S, 2007, ACTA PAEDIATR, V96, P1655, DOI 10.1111/j.1651-2227.2007.00488.x NR 10 TC 0 Z9 0 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD OCT PY 2013 VL 122 IS 10 BP 619 EP 624 PG 6 WC Otorhinolaryngology SC Otorhinolaryngology GA 239ZG UT WOS:000326063900004 PM 24294684 ER PT J AU Re, M Gioacchini, FM Salvolini, U Totaro, AM Santarelli, A Mallardi, V Magliulo, G AF Re, Massimo Gioacchini, Federico Maria Salvolini, Ugo Totaro, Anna Maria Santarelli, Andrea Mallardi, Vito Magliulo, Giuseppe TI Multislice Computed Tomography Overestimates Superior Semicircular Canal Dehiscence Syndrome SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE bone dehiscence; computed tomography; oscillopsia; semicircular canal; vertigo ID PRESSURE-INDUCED VERTIGO; TULLIO PHENOMENON; BONE DEHISCENCE; SOUND; CT; MALLEOSTAPEDOTOMY; SYMPTOMS; ROOF AB Objectives: We assessed the prevalence of superior semicircular canal dehiscence (SSCD) through examination of ultrahigh-resolution computed tomography (CT) scans of the temporal bone and attempted to verify the correspondence between a radiologic diagnosis of SSCD and clinical signs of SSCD syndrome. Methods: A prospective study was carried out on 191 consecutive patients who underwent temporal bone ultrahigh-resolution CT scans. Cases that matched the radiologic diagnosis of SSCD were subsequently referred for a comprehensive audiological evaluation that might enable a final diagnosis of SSCD syndrome. Results: Among the 191 patients, 17 had a radiologic diagnosis of SSCD, which was bilateral in 5 cases, for a total of 22 SSCD cases, with a prevalence rate of 5.8%. In 2 of the 17 patients, the audiological examination revealed signs and symptoms indicative of SSCD syndrome, with a total prevalence rate of 0.5%. Conclusions: Our data confirm that the radiologic diagnosis of SSCD, performed by mean thin-section CT scans reformatted in the plane of the superior semicircular canal, is not necessarily related to the clinical presentation of SSCD syndrome. Our study also showed a prevalence rate of SSCD syndrome that was similar to the prevalence of SSCD reported from studies of histologic specimens. C1 [Re, Massimo] Marche Polytech Univ, Dept Otorhinolaryngol, Ancona, Italy. [Salvolini, Ugo; Totaro, Anna Maria] Marche Polytech Univ, Dept Neuroradiol, Ancona, Italy. [Santarelli, Andrea] Marche Polytech Univ, Dept Special Clin Sci, Ancona, Italy. [Gioacchini, Federico Maria] Univ Hosp Modena, Dept Otorhinolaryngol, Modena, Italy. [Magliulo, Giuseppe] Univ Roma La Sapienza, G Ferreri Dept Otorhinolaryngol, Rome, Italy. RP Re, M (reprint author), Via Monteverde 8, I-63039 San Benedetto Tronto, AP, Italy. RI Santarelli, Andrea/P-6310-2014 OI Santarelli, Andrea/0000-0003-4218-3354 CR Belden CJ, 2003, RADIOLOGY, V226, P337, DOI 10.1148/radiol.2262010897 Brantberg K, 1999, ACTA OTO-LARYNGOL, V119, P633 Brantberg K, 2001, ACTA OTO-LARYNGOL, V121, P68 Carey JP, 2000, ARCH OTOLARYNGOL, V126, P137 Ceylan N, 2010, ACTA OTO-LARYNGOL, V130, P996, DOI 10.3109/00016481003602108 Cloutier JF, 2008, EUR ARCH OTO-RHINO-L, V265, P1455, DOI 10.1007/s00405-008-0672-2 Cremer PD, 2000, NEUROLOGY, V55, P1833 Curtin HD, 2003, RADIOLOGY, V226, P312, DOI 10.1148/radiol.2262021327 Halmagyi GM, 2003, J LARYNGOL OTOL, V117, P553 Magliulo G, 2007, J LARYNGOL OTOL, V121, P1148, DOI 10.1017/S0022215107008766 Magliulo G, 2013, LARYNGOSCOPE, V123, P492, DOI 10.1002/lary.23382 Masaki Y, 2011, ACTA OTO-LARYNGOL, V131, P258, DOI 10.3109/00016489.2010.526145 Merchant SN, 2007, ADV OTO-RHINO-LARYNG, V65, P137, DOI 10.1159/000098790 Minor LB, 2000, AM J OTOL, V21, P9 Minor LB, 1998, ARCH OTOLARYNGOL, V124, P249 Minor LB, 2005, LARYNGOSCOPE, V115, P1717, DOI 10.1097/01.mlg.000178324.55729.b7 Mong A, 1999, AM J NEURORADIOL, V20, P1973 Ostrowski VB, 2001, OTOL NEUROTOL, V22, P61, DOI 10.1097/00129492-200101000-00012 Pfammatter A, 2010, OTOL NEUROTOL, V31, P447, DOI 10.1097/MAO.0b013e3181d27740 Streubel S O, 2001, Acta Otolaryngol Suppl, V545, P41 Tsunoda A, 2002, J LARYNGOL OTOL, V116, P514 Watson SRD, 2000, NEUROLOGY, V54, P722 Williamson RA, 2003, OTOLARYNG HEAD NECK, V129, P481, DOI 10.1016/S0194-5998(03)01391-3 NR 23 TC 0 Z9 0 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD OCT PY 2013 VL 122 IS 10 BP 625 EP 631 PG 7 WC Otorhinolaryngology SC Otorhinolaryngology GA 239ZG UT WOS:000326063900005 PM 24294685 ER PT J AU Samuels, TL Pearson, ACS Wells, CW Stoner, GD Johnston, N AF Samuels, Tina L. Pearson, Amy C. S. Wells, Clive W. Stoner, Gary D. Johnston, Nikki TI Curcumin and Anthocyanin Inhibit Pepsin-Mediated Cell Damage and Carcinogenic Changes in Airway Epithelial Cells SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE berry; curcumin; head and neck cancer; laryngopharyngeal reflux; pepsin; reflux ID LYOPHILIZED BLACK-RASPBERRIES; NECK-CANCER EPIDEMIOLOGY; LARYNGOPHARYNGEAL REFLUX; BARRETTS-ESOPHAGUS; LARYNGEAL-CANCER; DIETARY PATTERNS; ECABET SODIUM; IN-VITRO; DISEASE; HEAD AB Objectives: Laryngopharyngeal reflux (LPR) is associated with inflammatory and neoplastic airway diseases. Gastric pepsin internalized by airway epithelial cells during reflux contributes to oxidative stress, inflammation, and carcinogenesis. Several plant extracts and compounds inhibit digestive enzymes and inflammatory or neoplastic changes to the esophagus in models of gastroesophageal reflux. This study examined the potential of chemoprotective phytochemicals to inhibit peptic activity and mitigate pepsin-mediated damage of airway epithelial cells. Methods: Cultured human laryngeal and hypopharyngeal epithelial cells were pretreated with curcumin (10 mu mol/L), ecabet sodium (1251 mu g/mL), and anthocyanin-enriched black-raspberry extract (100 mu g/mL) 30 minutes before treatment with pepsin (0.1 mg/mL; 1 hour; pH 7). Controls were treated with media pH 7 or pepsin pH 7 without phytochemicals. Cell damage and proliferative changes were assessed by electron microscopy, cell count, thymidine analog incorporation, and real-time polymerase chain reaction array. Pepsin inhibition was determined by in vitro kinetic assay. Results: Micromolar concentrations of curcumin, ecabet sodium, and black-raspberry extract inhibited peptic activity and pepsin-induced mitochondrial damage and hyperproliferation. Curcumin abrogated pepsin-mediated depression of tumor suppressor gene expression and altered the subcellular localization of pepsin following endocytosis. Conclusions: Several phytochemicals inhibit the pepsin-mediated cell damage underlying inflammatory or neoplastic manifestations of LPR. Dietary supplementation or adjunctive therapy with phytochemicals may represent novel preventive or therapeutic strategies for LPR-attributed disease. C1 [Samuels, Tina L.; Pearson, Amy C. S.; Johnston, Nikki] Med Coll Wisconsin, Dept Otolaryngol & Commun Sci, Milwaukee, WI 53226 USA. [Wells, Clive W.] Med Coll Wisconsin, Dept Microbiol & Mol Genet, Milwaukee, WI 53226 USA. [Stoner, Gary D.] Med Coll Wisconsin, Dept Med, Milwaukee, WI 53226 USA. [Stoner, Gary D.] Med Coll Wisconsin, Ctr Canc, Milwaukee, WI 53226 USA. RP Johnston, N (reprint author), Med Coll Wisconsin, Dept Otolaryngol & Commun Sci, 9200 W Wisconsin Ave, Milwaukee, WI 53226 USA. FU Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin FX This study was funded by the Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin. CR BERRYMAN MA, 1990, J HISTOCHEM CYTOCHEM, V38, P159 Bradshaw PT, 2012, AM J EPIDEMIOL, V175, P1225, DOI 10.1093/aje/kwr468 BURLEIGH BA, 1993, J CELL BIOL, V120, P339, DOI 10.1083/jcb.120.2.339 Cai XZ, 2013, PHYTOMEDICINE, V20, P495, DOI 10.1016/j.phymed.2012.12.007 Cammarota G, 2004, ANN SURG, V240, P817, DOI 10.1097/01.sla.0000143244.76135.ca Duffy SA, 2009, J CLIN ONCOL, V27, P1969, DOI 10.1200/JCO.2008.18.2188 Edefonti V, 2012, ANN ONCOL, V23, P1869, DOI 10.1093/annonc/mdr548 Furukawa O, 2000, DIGESTION, V62, P116, DOI 10.1159/000007804 GABRIEL C E, 1960, J Laryngol Otol, V74, P349, DOI 10.1017/S0022215100056693 Harris GK, 2001, NUTR CANCER, V40, P125, DOI 10.1207/S15327914NC402_8 HUANG MT, 1995, CARCINOGENESIS, V16, P2493, DOI 10.1093/carcin/16.10.2493 HUANG MT, 1994, CANCER RES, V54, P5841 Ingolfsson HI, 2007, BIOCHEMISTRY-US, V46, P10384, DOI 10.1021/bi701013n Johnston N, 2012, LARYNGOSCOPE, V122, P1317, DOI 10.1002/lary.23307 Johnston N, 2010, ANN OTO RHINOL LARYN, V119, P547 Johnston N, 2009, ANN OTO RHINOL LARYN, V118, P677 Johnston N, 2004, LARYNGOSCOPE, V114, P2129, DOI 10.1097/01.mlg.0000149445.07146.03 Koufman JA, 2011, ANN OTO RHINOL LARYN, V120, P281 Kresty LA, 2006, NUTR CANCER, V54, P148, DOI 10.1207/s15327914nc5401_15 Lagiou P, 2009, INT J CANCER, V124, P2671, DOI 10.1002/ijc.24246 Nagahama K, 2006, DIGEST DIS SCI, V51, P303, DOI 10.1007/s10620-006-3129-8 Pearson J P, 2011, Aliment Pharmacol Ther, V33 Suppl 1, P1, DOI 10.1111/j.1365-2036.2011.04581.x Pearson JP, 2001, CLIN SCI, V100, P411, DOI 10.1042/CS20000218 Prucksunand Chaweewan, 2001, Southeast Asian Journal of Tropical Medicine and Public Health, V32, P208 Rawat N, 2012, CLIN TRANSL ONCOL, V14, P302, DOI 10.1007/s12094-012-0799-x Samuels TL, 2008, ANN OTO RHINOL LARYN, V117, P688 Shumway BS, 2008, CLIN CANCER RES, V14, P2421, DOI 10.1158/1078-0432.CCR-07-4096 Stoner GD, 2008, FRONTIERS CANC PREVE, pA63 Takahashi M, 2007, MEDIAT INFLAMM, DOI 10.1155/2007/10767 Vaezi MF, 2006, LARYNGOSCOPE, V116, P254, DOI 10.1097/01.mlg.0000192173.00498.ba Vaezi MF, 2006, AM J MED, V119, P768, DOI 10.1016/j.amjmed.2006.01.019 Wang LS, 2009, CANCER PREV RES, V2, P84, DOI 10.1158/1940-6207.CAPR-08-0155 Yarimizu T, 1998, ONCOL REP, V5, P1103 NR 33 TC 0 Z9 0 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD OCT PY 2013 VL 122 IS 10 BP 632 EP 641 PG 10 WC Otorhinolaryngology SC Otorhinolaryngology GA 239ZG UT WOS:000326063900006 PM 24294686 ER PT J AU Alsaffar, H Sowerby, L Rotenberg, BW AF Alsaffar, Hussain Sowerby, Leigh Rotenberg, Brian W. TI Postoperative Nasal Debridement After Endoscopic Sinus Surgery: A Randomized Controlled Trial SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE chronic sinusitis; endoscopic sinus surgery; nasal debridement; randomized controlled trial ID CHRONIC RHINOSINUSITIS; SURGICAL OUTCOMES; CARE AB Objectives: Postoperative debridement is a controversial subject in the rhinology literature. The objective of this randomized controlled trial was to determine the effect of regular debridement versus no debridement on disease-specific outcomes and patient inconvenience. Methods: Patients with chronic rhinosinusitis with polyposis who were to undergo basic sinus surgery (antrostomy, ethmoidectomy, and polypectomy) were randomized to either debridement (at postoperative weeks 2 and 4) or no debridement, and their outcomes were assessed at 4 weeks and at 6 months with the Lund-Kennedy Endoscopic Score (LKES), the Sino-Nasal Outcome Test-21 (SNOT-21), a visual analog scale for postoperative pain, and a novel scoring system for postoperative inconvenience (Post-Operative Inconvenience Scale; POTS). All patients were instructed to use high-volume saline rinses twice daily. Results: At 4 weeks after operation, there was no difference between the groups in regard to LKESs (control group, 2.1 of 20; debridement group, 2.4 of 20; p = 0.59) or SNOT scores (control group, 9.1; debridement group, 8.3; p = 0.47). The visual analog scale pain scores showed significance (control group, 19 mm; debridement group, 38 mm; p = 0.019), as did the POTS scores (control group, 18.3; debridement group, 6.1; p = 0.002). At 6 months after surgery, again no difference was seen between the groups on either LKESs or SNOT scores. Conclusions: In our patient population, debridement after surgery did not affect disease-specific outcomes. C1 [Alsaffar, Hussain; Sowerby, Leigh; Rotenberg, Brian W.] Univ Western Ontario, Dept Otolaryngol Head & Neck Surg, St Josephs Hlth Care London, Schulich Sch Med & Dent, London, ON, Canada. RP Rotenberg, BW (reprint author), St Josephs Hlth Care London, 268 Grosvenor St, London, ON N6A 4V2, Canada. CR Bugten V, 2006, LARYNGOSCOPE, V116, P2037, DOI 10.1097/01.mlg.0000241362.06072.83 Desrosiers M, 2011, ALLERGY ASTHMA CL IM, V7, DOI 10.1186/1710-1492-7-2 Fernandes SV, 1999, LARYNGOSCOPE, V109, P945, DOI 10.1097/00005537-199906000-00020 Hessler JL, 2007, AM J RHINOL, V21, P10, DOI 10.2500/ajr.2007.21.2960 Kemppainen T, 2008, RHINOLOGY, V46, P238 Lee JY, 2008, LARYNGOSCOPE, V118, P1868, DOI 10.1097/MLG.0b013e31817f93d3 Lund V J, 1995, Ann Otol Rhinol Laryngol Suppl, V167, P17 Nilssen ELK, 2002, J LARYNGOL OTOL, V116, P108 Ramakrishnan VR, 2011, LARYNGOSCOPE, V121, P8, DOI 10.1002/lary.21351 Rudmik L, 2011, INT FORUM ALLERGY RH, V1, P417, DOI 10.1002/alr.20072 SCHULZ KF, 2010, ANN INTERN MED, V152, P1 Smith TL, 2005, AM J RHINOL, V19, P537 Soler ZM, 2010, OTOLARYNG HEAD NECK, V143, P621, DOI 10.1016/j.otohns.2010.07.014 Wright ED, 2007, LARYNGOSCOPE, V117, P1, DOI 10.1097/MLG.0b013e31814842f8 NR 14 TC 2 Z9 3 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD OCT PY 2013 VL 122 IS 10 BP 642 EP 647 PG 6 WC Otorhinolaryngology SC Otorhinolaryngology GA 239ZG UT WOS:000326063900007 PM 24294687 ER PT J AU Ozkiris, M Karacavus, S Kapusuz, Z Balbaloglu, O Saydam, L AF Ozkiris, Mahmut Karacavus, Seyhan Kapusuz, Zeliha Balbaloglu, Ozlem Saydam, Levent TI Does Bone Mineral Density Have an Effect on Hearing Loss in Postmenopausal Patients? SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE hearing loss; osteopenia; osteoporosis ID COCHLEAR CAPSULE; OLDER-ADULTS; PREVALENCE; WOMEN; DENSITOMETRY; OTOSCLEROSIS; EPIDEMIOLOGY; REPLACEMENT; SENSITIVITY; THERAPY AB Objectives: An age-related decline in the bone mineral density (BMD) of the temporal bone, specifically in the segments that house the middle and inner ear, has been suggested as an additional risk factor for sensorineural hearing loss. We evaluated the effect of BMD on hearing loss in postmenopausal patients. Methods: This study involved 120 postmenopausal women who were referred between May 1, 2012, and September 1, 2012. The age range was 50 to 55 years (mean, 52.7 +/- 2.3 years). The subjects were divided into three groups according to the results of BMD measurements. Of these, 30 were control subjects with normal BMD values, 45 had osteopenia, and 45 had osteoporosis. Each subject was tested with low- and high-frequency audiometry by a single experienced investigator under standard audiometric testing conditions. For each set of tests, mean values of air and bone conduction at each frequency and tympanometric values were calculated for the osteopenia, osteoporosis, and control groups. Results: All three groups were designed to have similar mean ages and roughly equal durations of menopause and body mass indexes. At low frequencies (0.25, 0.5, 1, and 2 kHz), the differences in the mean air conduction threshold values among the three groups were not statistically significant (p > 0.05). At high frequencies (4, 6, and 8 kHz), the difference in the mean air conduction threshold values between the osteopenia and control groups was not statistically significant (p > 0.05), but that in the osteoporosis group was statistically significantly higher than those in the osteopenia and control groups (p < 0.05). At low frequencies (0.5, 1, and 2 kHz), the differences in the mean bone conduction threshold values among the three groups were not statistically significant (p > 0.05). At 4 kHz, the difference in the mean bone conduction threshold values between the osteopenia and control groups was not statistically significant (p > 0.05), but that in the osteoporosis group was statistically significantly higher than those in the osteopenia and control groups (p < 0.05). There was no statistically significant difference among the three groups in tympanometric values (p > 0.05). Conclusions: We conclude that patients with low BMD values should routinely be counseled for an audiological assessment to detect any change in hearing thresholds. C1 [Ozkiris, Mahmut; Kapusuz, Zeliha; Saydam, Levent] Bozok Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, Yozgat, Turkey. [Karacavus, Seyhan] Bozok Univ, Sch Med, Dept Nucl Med, Yozgat, Turkey. [Balbaloglu, Ozlem] Bozok Univ, Sch Med, Dept Phys Med & Rehabil, Yozgat, Turkey. RP Ozkiris, M (reprint author), Adnan Menderes Bulvan 42, Yozgat, Turkey. CR [Anonymous], 2000, NIH CONSENS STATEMEN, V17, P1 Ciorba A, 2012, CLIN INTERV AGING, V7, P159, DOI 10.2147/CIA.S26059 Clark Kathleen, 1995, Annals of Epidemiology, V5, P8, DOI 10.1016/1047-2797(94)00035-R COLEMAN JR, 1994, HEARING RES, V80, P209, DOI 10.1016/0378-5955(94)90112-0 Cruickshanks KJ, 1998, AM J EPIDEMIOL, V148, P879 Dalton DS, 2003, GERONTOLOGIST, V43, P661 Davis A C, 1990, Acta Otolaryngol Suppl, V476, P23 Gates GA, 2005, LANCET, V366, P1111, DOI 10.1016/S0140-6736(05)67423-5 Guneri EA, 1996, ANN OTO RHINOL LARYN, V105, P659 Hederstierna C, 2007, ACTA OTO-LARYNGOL, V127, P149, DOI 10.1080/00016480600794446 Helzner EP, 2005, OSTEOPOROSIS INT, V16, P1675, DOI 10.1007/s00198-005-1902-8 HINCHCLIFFE R, 1991, ACTA OTO-LARYNGOL, P7 HUIZING EH, 1987, ACTA OTO-LARYNGOL, V103, P464 KHAN A, 1984, J MED, V15, P279 Kilicdag EB, 2004, AM J OBSTET GYNECOL, V190, P77, DOI 10.1016/j.ajpg.2003.06.001 Kim SH, 2002, OBSTET GYNECOL, V99, P726, DOI 10.1016/S0029-7844(02)01963-4 Meunier PJ, 1972, ORTHOPEDIA CLINICS N, V3, P745 MONSELL EM, 1995, HEARING RES, V83, P114, DOI 10.1016/0378-5955(94)00196-W Reginster JY, 2006, BONE, V38, P54 Roth TN, 2011, EUR ARCH OTO-RHINO-L, V268, P1101, DOI 10.1007/s00405-011-1597-8 World Health Organization, 1994, WHO TECHN REP SER, V843 NR 21 TC 2 Z9 2 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD OCT PY 2013 VL 122 IS 10 BP 648 EP 652 PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA 239ZG UT WOS:000326063900008 PM 24294688 ER PT J AU Halum, SL Bijangi-Vishehsaraei, K Saadatzadeh, MR McRae, BR AF Halum, Stacey L. Bijangi-Vishehsaraei, Khadijeh Saadatzadeh, M. Reza McRae, Bryan R. TI Differences in Laryngeal Neurotrophic Factor Gene Expression After Recurrent Laryngeal Nerve and Vagus Nerve Injuries SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE denervation; larynx; recurrent laryngeal nerve; reinnervation; trophic factor; vagus nerve ID SKELETAL-MUSCLE; REINNERVATION; REGENERATION; PARALYSIS; MODEL; RAT AB Objectives: Recurrent laryngeal nerve (RLN) and vagus nerve (VN) injuries characteristically are followed by differing degrees of spontaneous reinnervation, yet laryngeal muscle neurotrophic factor (NF) expression profiles after RLN and VN injuries have not been well elucidated. This study's objective was to determine the relative changes in gene expression of 5 well-characterized NFs from laryngeal muscle after RLN or VN injuries in a time-dependent fashion, and demonstrate how these changes correspond with electromyography-assessed innervation status. Methods: Thirty-six male rats underwent left RLN transection (12 rats), left VN transection (12 rats), or a sham procedure (12 rats). The primary outcomes included electromyographic assessment and laryngeal muscle NF expression quantification with reverse transcription polymerase chain reaction at 3 days and at 1 month. Results: Electromyography at 3 days demonstrated electrical silence in the VN injury group, normal activity in the sham group, and nascent units with decreased recruitment in the RLN injury group. Reverse transcription polymerase chain reaction demonstrated that changes in NF gene expression from laryngeal muscles varied depending on the type of nerve injury (RLN or VN) and the specific laryngeal muscle (posterior cricoarytenoid or adductor) assessed. Conclusions: Laryngeal muscle NF expression profiles after cranial nerve X injury depend both upon the level of nerve injury and upon the muscles involved. C1 [Halum, Stacey L.; Bijangi-Vishehsaraei, Khadijeh; Saadatzadeh, M. Reza; McRae, Bryan R.] Indiana Univ Sch Med, Dept Otolaryngol Head & Neck Surg, Indianapolis, IN 46202 USA. RP Halum, SL (reprint author), Dept Otolaryngol Head & Neck Surg, 950 W Walnut St,Res Bldg 2,E425, Indianapolis, IN 46202 USA. FU National Institute on Deafness and Other Communication Disorders within the National Institutes of Health [K08DC009583] FX These projects were supported by award K08DC009583 from the National Institute on Deafness and Other Communication Disorders within the National Institutes of Health. This study was performed in accordance with the PHS Policy on Humane Care and Use of Laboratory Animals, the NIH Guide for the Care and Use of Laboratory Animals, and the Animal Welfare Act (7 U.S.C. et seq.); the animal use protocol was approved by the Institutional Animal Care and Use Committee (IACUC) of Indiana University. CR Blitzer A, 1996, ANN OTO RHINOL LARYN, V105, P764 Borselli C, 2010, P NATL ACAD SCI USA, V107, P3287, DOI 10.1073/pnas.0903875106 Boyd JG, 2003, EXP NEUROL, V183, P610, DOI 10.1016/S0014-4886(03)00183-3 CARONI P, 1990, J CELL BIOL, V110, P1307, DOI 10.1083/jcb.110.4.1307 Day CS, 2002, MICROSURG, V22, P144, DOI 10.1002/micr.21742 FUNAKOSHI H, 1993, J CELL BIOL, V123, P455, DOI 10.1083/jcb.123.2.455 HELGREN ME, 1994, CELL, V76, P493, DOI 10.1016/0092-8674(94)90113-9 Hydman J, 2008, MUSCLE NERVE, V38, P1280, DOI 10.1002/mus.21124 Inagi K, 1998, OTOLARYNG HEAD NECK, V118, P74, DOI 10.1016/S0194-5998(98)70378-X Koufman JA, 1998, PHONOSCOPE, V1, P57 KOUFMAN JA, 1995, LARYNGOSCOPE, V105, P368, DOI 10.1288/00005537-199504000-00005 KWON YW, 1994, NEUROREPORT, V5, P789, DOI 10.1097/00001756-199403000-00013 Maranillo E, 2003, LARYNGOSCOPE, V113, P525, DOI 10.1097/00005537-200303000-00024 Maranillo E, 2005, LARYNGOSCOPE, V115, P358, DOI 10.1097/01.mlg.0000154745.78808.02 Newman JP, 1996, ARCH OTOLARYNGOL, V122, P399 NOMOTO M, 1991, BRAIN RES, V539, P276, DOI 10.1016/0006-8993(91)91632-B Nomoto M, 1993, Acta Otolaryngol Suppl, V506, P71 Old MO, 2011, ANN OTO RHINOL LARYN, V120, P331 Omura T, 2005, J PERIPHER NERV SYST, V10, P293, DOI 10.1111/j.1085-9489.2005.10307.x Pascual-Font A, 2011, J ANAT, V219, P217, DOI 10.1111/j.1469-7580.2011.01390.x Sataloff RT, 2010, J VOICE, V24, P228, DOI 10.1016/j.jvoice.2008.08.005 Semon F, 1881, ARCH LARYNGOL, V2, P197 Vega-Cordova X, 2010, LARYNGOSCOPE, V120, P1591, DOI 10.1002/lary.21026 Woodson GE, 2008, LARYNGOSCOPE, V118, P1768, DOI 10.1097/MLG.0b013e31817f1940 WOODSON GE, 1993, LARYNGOSCOPE, V103, P1227 Woodson GE, 2007, ANN OTO RHINOL LARYN, V116, P57 NR 26 TC 0 Z9 0 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD OCT PY 2013 VL 122 IS 10 BP 653 EP 663 PG 11 WC Otorhinolaryngology SC Otorhinolaryngology GA 239ZG UT WOS:000326063900009 PM 24294689 ER PT J AU Upton, DC Johnson, M Zelazny, SK Dailey, SH AF Upton, David C. Johnson, Matthew Zelazny, Sherri K. Dailey, Seth H. TI Prospective Evaluation of Office-Based Injection Laryngoplasty With Hyaluronic Acid Gel SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE glottic insufficiency; hyaluronic acid; injection laryngoplasty; Juvederm; office-based surgery ID AUGMENTATION; VISCOELASTICITY; SEVERITY; FILLERS; SAFETY; INDEX AB Objectives: The role of Juvederm Ultra Plus hyaluronic acid gel for use in injection laryngoplasty has not been well examined. The aim of this study was to prospectively assess the safety and clinical effectiveness of office-based injection laryngoplasty of Juvederm Ultra Plus gel in patients with glottic insufficiency. Methods: Thirty patients met the criteria for study inclusion and were treated with unsedated office-based injection laryngoplasty of Juvederm Ultra Plus gel over a 20-month period. The preinjection acoustic and aerodynamic measures, Voice Handicap Index, Glottal Function Index, and Dysphonia Severity Index were compared with values recorded at 1 and 4 months after injection. Results: Data for 27 patients were available for follow-up analysis at 1 month, and 12 patients' data were available at 4 months. Significant improvements, compared to preinjection levels (p < 0.02), were shown in all outcome measures at 1 and 4 months. One patient required intravenous steroid therapy for delayed glottic inflammation that resolved without permanent sequelae. Conclusions: The injection of Juvederm Ultra Plus gel is a relatively safe procedure that allows for short-term improvements in objective and subjective outcome measures of vocal function in patients with glottic insufficiency, provided the surgeon remains alert to the possibility of postprocedural injection site inflammation. C1 [Upton, David C.; Johnson, Matthew; Zelazny, Sherri K.; Dailey, Seth H.] Univ Wisconsin Hosp & Clin, Dept Surg, Div Otolaryngol, Madison, WI 53792 USA. RP Upton, DC (reprint author), Univ Wisconsin Hosp & Clin, Div Otolaryngol, 600 Highland Ave, Madison, WI 53792 USA. CR Anderson TD, 2001, LARYNGOSCOPE, V111, P1318, DOI 10.1097/00005537-200108000-00002 Andrade PA, 2006, AM J OTOLARYNG, V27, P319, DOI 10.1016/j.amjoto.2006.01.009 Bach KK, 2005, ARCH OTOLARYNGOL, V131, P961, DOI 10.1001/archotol.131.11.961 Baumann LS, 2007, DERMATOL SURG, V33, pS128, DOI 10.1111/j.1524-4725.2007.33352.x BIERI D, 1990, PAIN, V41, P139, DOI 10.1016/0304-3959(90)90018-9 Bruening W., 1911, VERH DTSCH LARYNG, V18, P23 Caton T, 2007, LARYNGOSCOPE, V117, P516, DOI 10.1097/MLG.0b013e31802e9291 Courey MS, 2004, OTOLARYNG CLIN N AM, V37, P121, DOI 10.1016/j.otc.2003.12.002 Dahlqvist A, 2004, LARYNGOSCOPE, V114, P138 Hertegard S, 2002, LARYNGOSCOPE, V112, P2211, DOI 10.1097/00005537-200212000-00016 Jacobson BH, 1997, AM J SPEECH-LANG PAT, V6, P66 Lau DP, 2010, J VOICE, V24, P113, DOI 10.1016/j.jvoice.2008.05.007 Manna F, 1999, J EUR ACAD DERMATOL, V13, P183 Molteni G, 2010, OTOLARYNG HEAD NECK, V142, P547, DOI 10.1016/j.otohns.2009.12.035 Owens JM, 2005, OTOLARYNG CLIN N AM, V38, P361, DOI 10.1016/j.otc.2004.10.003 Shamanna SG, 2011, J OTOLARYNGOL-HEAD N, V40, pE39, DOI 10.2310/7070.2011.100283 Tirado Y, 2010, LARYNGOSCOPE, V120, P703, DOI 10.1002/lary.20808 Wuyts FL, 2000, J SPEECH LANG HEAR R, V43, P796 NR 18 TC 2 Z9 2 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD SEP PY 2013 VL 122 IS 9 BP 541 EP 546 PG 6 WC Otorhinolaryngology SC Otorhinolaryngology GA 220RE UT WOS:000324603800001 PM 24224395 ER PT J AU Chee, M Sasaki, C AF Chee, Michael Sasaki, Clarence TI Carbon Dioxide Laser Fiber for the Excision of Oral Leukoplakia SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE carbon dioxide laser; leukoplakia ID MICROSCOPIC CUT-THROUGH; CO2-LASER; CARCINOMA; SURGERY AB Objectives: We compared the efficacies of cold knife excision and carbon dioxide (CO2) laser fiber excision of oral cavity leukoplakia. Methods: Between August 2009 and June 2011, 45 patients who underwent excision of oral cavity leukoplalda were assessed for operative time, use of bipolar cautery, blood loss, and number of intraoperative margins needed. Patients were assigned randomly to either a cold knife group (23 procedures) or a CO2 laser fiber group (24 procedures) at the time of the procedure. Results: The times of excision were siinilar in the CO2 laser fiber group (1.64 min/cm(2)) and the cold knife group (1.70 min/cm(2)). There were large differences between the CO2 laser fiber group and the cold knife group in the categories of bipolar cautery uses per square centimeter (0.34 uses versus 3.32 uses) and blood loss (0.19 g/cm(2) versus 2.55 g/cm(2)). The average number of margins needed to clear a specimen by frozen section was 1.21 for the CO2 laser fiber group and 1.83 for the cold knife group. Conclusions: The CO2 laser fiber did not show an advantage in operative time. The CO2 laser fiber did show better outcomes in the areas of blood loss, bipolar cautery use, and intraoperative margins needed. C1 [Chee, Michael; Sasaki, Clarence] Yale Univ, Sch Med, Dept Surg, Sect Otolaryngol Head & Neck Surg, New Haven, CT 06510 USA. RP Chee, M (reprint author), Johns Hopkins Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, 601 N Caroline St,JHOC 6th Floor, Baltimore, MD 21287 USA. FU Virginia Wright Foundation FX From the Department of Surgery, Section of Otolaryngology-Head and Neck Surgery, Yale School of Medicine, New Haven, Connecticut. OmniGuide Inc provided the flexible carbon dioxide laser fiber used in the study, and the Virginia Wright Foundation provided funding for data collection by the nursing staff. CR CHU FWK, 1988, LARYNGOSCOPE, V98, P125 FRAME JW, 1985, J ORAL MAXIL SURG, V43, P850, DOI 10.1016/0278-2391(85)90221-6 Guillemaud JP, 2010, J OTOLARYNGOL-HEAD N, V39, P370, DOI 10.2310/7070.2010.090084 Holsinger FC, 2006, LARYNGOSCOPE, V116, P1288, DOI 10.1097/01.mlg.0000227557.61978.18 Ishii J, 2003, ORAL ONCOL, V39, P759, DOI 10.1016/S1368-8375(03)00043-5 ROODENBURG JLN, 1991, ORAL SURG ORAL MED O, V71, P670, DOI 10.1016/0030-4220(91)90271-D SCHOLL P, 1986, AM J SURG, V152, P354, DOI 10.1016/0002-9610(86)90304-1 Schulz KF, 2011, INT J SURG, V9, P672, DOI 10.1016/j.ijsu.2011.09.004 Temelkuran B, 2002, NATURE, V420, P650, DOI 10.1038/nature01275 NR 9 TC 0 Z9 0 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD SEP PY 2013 VL 122 IS 9 BP 547 EP 549 PG 3 WC Otorhinolaryngology SC Otorhinolaryngology GA 220RE UT WOS:000324603800002 PM 24224396 ER PT J AU Puttgen, KB Summerer, B Schneider, J Cohen, BA Boss, EF Bauman, NM AF Puttgen, Katherine B. Summerer, Barbara Schneider, Jeremy Cohen, Bernard A. Boss, Emily F. Bauman, Nancy M. TI Cardiovascular and Blood Glucose Parameters in Infants During Propranolol Initiation for Treatment of Symptomatic Infantile Hemangiomas SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE blood pressure; cardiovascular system; heart rate; infantile hemangioma; propranolol ID CHILDREN AB Objectives: We sought to determine the effect of propranolol on cardiovascular and blood glucose parameters in infants with symptomatic infantile hemangiomas who were hospitalized for initiation of treatment, and to analyze adverse effects of propranolol throughout the course of inpatient and outpatient treatment. Methods: A retrospective cohort analysis was performed on 50 infants (age less than 12 months) with symptomatic infantile hemangiomas who were hospitalized for propranolol initiation between 2008 and 2012. Demographic data and disease characteristics were recorded. Systolic and diastolic blood pressures, heart rate, blood glucose values, and adverse events recorded during hospitalization were analyzed. An additional cohort of 200 consecutively treated children was also assessed for adverse events associated with outpatient propranolol use. Results: The median age among the inpatient cohort was 3.4 months (range, 0.8 to 12.0 months). Infants older than 6 months were more likely to exhibit bradycardia than were younger infants (p < 0.001). Hypotensive and/or bradycardic periods were infrequent and were not associated with observable clinical symptoms. The mean systolic and diastolic blood pressures and the mean heart rate decreased significantly from day 1 of hospitalization to day 2 (p = 0.004; p = 0.008; p < 0.001), but not from day 2 to day 3, when the propranolol dose was increased to target. Hypoglycemia was rare (0.3% incidence.) Among the 250 outpatients, 2 infants developed lethargy and hypoglycemia during a viral illness and recovered without sequelae. One infant experienced recurrent bronchospasm with viral illnesses and required concomitant bronchodilator therapy. Conclusions: Frequent deviations from normal ranges of blood pressure and heart rate occur upon initiation of propranolol, but are clinically asymptomatic. These findings support that outpatient initiation of propranolol in healthy, normotensive infants appears to be a relatively safe alternative to inpatient initiation. Hypoglycemia is rare, but can occur throughout the treatment period; parent counseling is of paramount importance. C1 [Puttgen, Katherine B.; Summerer, Barbara; Schneider, Jeremy; Cohen, Bernard A.] Johns Hopkins Univ, Sch Med, Dept Dermatol, Baltimore, MD 21287 USA. [Boss, Emily F.] Johns Hopkins Univ, Sch Med, Dept Otolaryngol, Baltimore, MD 21287 USA. [Bauman, Nancy M.] Childrens Natl Med Ctr, Dept Otolaryngol, Washington, DC 20010 USA. RP Puttgen, KB (reprint author), Johns Hopkins Univ, Sch Med, Dept Dermatol, 200 N Wolfe St,Unit 2107, Baltimore, MD 21287 USA. FU NIH [5R21HD062959-02] FX From the Departments of Dermatology (Puttgen, Summerer, Schneider, Cohen) and Otolaryngology (Boss), Johns Hopkins University School of Medicine, Baltimore, Maryland, and the Department of Otolaryngology, Children's National Medical Center, Washington, DC (Bauman). This work was supported by NIH grant 5R21HD062959-02. CR Dionne JM, 2012, PEDIATR NEPHROL, V27, P159, DOI 10.1007/s00467-011-1978-7 Drolet BA, 2013, PEDIATRICS, V131, P128, DOI 10.1542/peds.2012-1691 Fleming S, 2011, LANCET, V377, P1011, DOI 10.1016/S0140-6736(10)62226-X Hospital Johns Hopkins, 2012, HARRIET LANE HDB Hussain T, 2009, ARCH DIS CHILD, V94, P968, DOI 10.1136/adc.2008.145052 Kahler Allan C, 2002, Pediatr Crit Care Med, V3, P370, DOI 10.1097/00130478-200210000-00008 KALLEN RJ, 1980, CLIN PEDIATR, V19, P567, DOI 10.1177/000992288001900814 Kent AL, 2007, PEDIATR NEPHROL, V22, P1743, DOI 10.1007/s00467-007-0561-8 Leaute-Labreze C, 2008, NEW ENGL J MED, V358, P2649, DOI 10.1056/NEJMc0708819 Marqueling AL, 2013, PEDIATR DERMATOL, V30, P182, DOI 10.1111/pde.12089 Strafford M, 2006, SMITHS ANESTHESIA IN, P70 NR 11 TC 5 Z9 5 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD SEP PY 2013 VL 122 IS 9 BP 550 EP 554 PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA 220RE UT WOS:000324603800003 PM 24224397 ER PT J AU Zhuang, PY Swinarska, JT Robieux, CF Hoffman, MR Lin, SZ Jiang, JJ AF Zhuang, Peiyun Swinarska, Joanna T. Robieux, Camille F. Hoffman, Matthew R. Lin, Shengzhi Jiang, Jack J. TI Measurement of Phonation Threshold Power in Normal and Disordered Voice Production SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE aerodynamic parameters; artificial neural network; mass lesion; phonation threshold power; vocal fold paralysis; voice analysis ID AIR-FLOW INTERRUPTION; EXCISED LARYNGES; PRESSURE; HYDRATION; POLYPS; MODEL AB Objectives: Phonation threshold pressure (PTP) and phonation threshold flow (PTF) are useful aerodynamic parameters, but each is sensitive to different disorders. A single comprehensive aerodynamic parameter sensitive to a variety of disorders might be beneficial in quantitative voice assessment. We performed the first study of phonation threshold power (PTW) in human subjects. Methods: PTP and PTF were measured in 100 normal subjects, 19 subjects with vocal fold immobility, and 94 subjects with a benign mass lesion. PTW was calculated from these two parameters. In 41 subjects with a polyp, measurements were obtained before and after excision. Receiver operating characteristic (ROC) analysis was used to determine the ability of the three parameters to distinguish between controls and disordered groups. Results: The PTW (p < 0.001), PTP (p < 0.001), and PTF (p < 0.001) were different among the three groups. All parameters decreased after polyp excision. PTW had the highest area under the ROC curve for all analyses. Conclusions: PTW is sensitive to the presence of mass lesions and vocal fold mobility disorders. Additionally, changes in PTW can be observed after excision of mass lesions. PTW could be a useful parameter to describe the aerodynamic inputs to voice production. C1 [Zhuang, Peiyun; Lin, Shengzhi] Xiamen Univ, Zhongshan Hosp, Dept Otolaryngol, Xiamen, Peoples R China. [Swinarska, Joanna T.; Robieux, Camille F.; Hoffman, Matthew R.; Jiang, Jack J.] Univ Wisconsin, Dept Surg, Div Otolaryngol Head & Neck Surg, Sch Med & Publ Hlth, Madison, WI USA. RP Jiang, JJ (reprint author), 1300 Univ Ave,2725 Med Sci Ctr, Madison, WI 53706 USA. FU National Natural Science Foundation of China [81070773, 81028004]; NIH National Institute on Deafness and Other Communication Disorders [R01 DC008153] FX From the Department of Otolaryngology, Xiamen University Zhongshan Hospital (Zhuang, Lin), Xiamen, China, and the Department of Surgery, Division of Otolaryngology-Head and Neck Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin (Swinarska, Robieux, Hoffman, Jiang). This study was funded by grants 81070773 and 81028004 from the National Natural Science Foundation of China and by NIH grant R01 DC008153 from the National Institute on Deafness and Other Communication Disorders. CR Baken RJ, 2000, CLIN MEASUREMENT SPE Berke GS, 2011, J ACOUST SOC AM, V130, P2440 CRUMLEY RL, 1994, J VOICE, V8, P79, DOI 10.1016/S0892-1997(05)80323-6 Hirano S, 2004, LARYNGOSCOPE, V114, P548, DOI 10.1097/00005537-200403000-00030 Hoffman MR, 2009, LARYNGOSCOPE, V119, P1851, DOI 10.1002/lary.20572 Hottinger DG, 2007, LARYNGOSCOPE, V117, P1695, DOI 10.1097/MLG.0b013e3180959e38 Jiang J, 1999, J VOICE, V13, P583, DOI 10.1016/S0892-1997(99)80012-5 Jiang J, 2004, ANN OTO RHINOL LARYN, V113, P277 Jiang J, 1999, LARYNGOSCOPE, V109, P425, DOI 10.1097/00005537-199903000-00016 Jiang J, 2000, OTOLARYNG CLIN N AM, V33, P699, DOI 10.1016/S0030-6665(05)70238-3 Jiang JJ, 2007, J ACOUST SOC AM, V121, P2873, DOI 10.1121/1.2710961 Jiang JJ, 2008, ANN OTO RHINOL LARYN, V117, P548 Ma EPM, 2006, J VOICE, V20, P380, DOI 10.1016/j.jvoice.2005.04.007 Regner MF, 2011, J VOICE, V25, P519, DOI 10.1016/j.jvoice.2010.04.001 Rousseau B, 2006, J VOICE, V20, P443, DOI 10.1016/j.jvoice.2005.06.002 SMITHERAN JR, 1981, J SPEECH HEAR DISORD, V46, P138 Solomon NP, 2000, J VOICE, V14, P341 Titze I. R., 1988, VOCAL PHYSL VOICE PR, P227 TITZE IR, 1995, J ACOUST SOC AM, V97, P3080, DOI 10.1121/1.411870 TITZE IR, 1992, J ACOUST SOC AM, V91, P2926, DOI 10.1121/1.402928 VERDOLINI K, 1994, J SPEECH HEAR RES, V37, P1001 Wang TG, 2010, J FORMOS MED ASSOC, V109, P62 Witt RE, 2009, ANN OTO RHINOL LARYN, V118, P154 Zhuang P, 2009, LARYNGOSCOPE, V119, P811, DOI 10.1002/lary.20165 ZWEIG MH, 1993, CLIN CHEM, V39, P561 NR 25 TC 1 Z9 1 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD SEP PY 2013 VL 122 IS 9 BP 555 EP 560 PG 6 WC Otorhinolaryngology SC Otorhinolaryngology GA 220RE UT WOS:000324603800004 PM 24224398 ER PT J AU Moon, J Alipour, F AF Moon, Jerald Alipour, Fariborz TI Muscular Anatomy of the Human Ventricular Folds SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE histologic study; human larynx; ventricular fold; ventricular muscle ID FALSE VOCAL FOLDS; PHONATION; LARYNX AB Objectives: Our purpose in this study was to better understand the muscular anatomy of the ventricular folds in order to help improve biomechanical modeling of phonation and to better understand the role of these muscles during phonatory and nonphonatory tasks. Methods: Four human larynges were decalcified, sectioned coronally from posterior to anterior by a CryoJane tape transfer system, and stained with Masson's trichrome. The total and relative areas of muscles observed in each section were calculated and used for characterizing the muscle distribution within the ventricular folds. Results: The ventricular folds contained anteriorly coursing thyroarytenoid and ventricularis muscle fibers that were in the lower half of the ventricular fold posteriorly, and some ventricularis muscle was evident in the upper and lateral portions of the fold more anteriorly. Very little muscle tissue was observed in the medial half of the fold, and the anterior half of the ventricular fold was largely devoid of any muscle tissue. All 4 larynges contained muscle bundles that coursed superiorly and medially through the upper half of the fold, toward the lateral margin of the epiglottis. Conclusions: Although variability of expression was evident, a well-defined thyroarytenoid muscle was readily apparent lateral to the arytenoid cartilage in all specimens. C1 [Moon, Jerald; Alipour, Fariborz] Univ Iowa, Dept Commun Sci & Disorders, Iowa City, IA 52242 USA. RP Alipour, F (reprint author), Univ Iowa, 334E WJSHC, Iowa City, IA 52242 USA. FU National Institute on Deafness and Other Communication Disorders [R01DC009567] FX From the Department of Communication Sciences and Disorders, University of Iowa, Iowa City, Iowa. The project was supported by award R01DC009567 from the National Institute on Deafness and Other Communication Disorders. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institute on Deafness and Other Communication Disorders or the National Institutes of Health. CR Agarwal M, 2003, J VOICE, V17, P97, DOI 10.1016/S0892-1997(03)00012-2 Alipour F, 2000, J ACOUST SOC AM, V108, P3003, DOI 10.1121/1.1324678 Alipour F, 2007, ANN OTO RHINOL LARYN, V116, P135 Aoyagi S, 1995, Nihon Jibiinkoka Gakkai Kaiho, V98, P627 Finnegan EM, 2009, J VOICE, V23, P51, DOI 10.1016/j.jvoice.2007.01.004 Guida HL, 2000, ANN OTO RHINOL LARYN, V109, P67 KOTBY MN, 1991, ACTA OTO-LARYNGOL, V111, P396, DOI 10.3109/00016489109137409 Kutta H, 2002, ANAT EMBRYOL, V205, P315, DOI 10.1007/s00429-002-0255-8 Lindestad PA, 2001, J VOICE, V15, P78, DOI 10.1016/S0892-1997(01)00008-X MOTTA G, 1953, Otorinolaringol Ital, V21, P215 Pinho SMR, 1999, J VOICE, V13, P36, DOI 10.1016/S0892-1997(99)80059-9 Reidenbach MM, 1998, EUR ARCH OTO-RHINO-L, V255, P365, DOI 10.1007/s004050050078 Ricz H, 2010, ARCH OTOLARYNGOL, V136, P616, DOI 10.1001/archoto.2010.74 Stager SV, 2000, J SPEECH LANG HEAR R, V43, P229 Zemlin WR., 1989, SPEECH HEARING SCI A NR 15 TC 1 Z9 1 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD SEP PY 2013 VL 122 IS 9 BP 561 EP 567 PG 7 WC Otorhinolaryngology SC Otorhinolaryngology GA 220RE UT WOS:000324603800005 PM 24224399 ER PT J AU Pollei, TR Hinni, ML Hayden, RE Lott, DG Mors, MB AF Pollei, Taylor R. Hinni, Michael L. Hayden, Richard E. Lott, David G. Mors, Matthew B. TI Comparison of Carbon Dioxide Laser-Assisted Versus Stapler-Assisted Endoscopic Cricopharyngeal Myotomy SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE carbon dioxide laser; cricopharyngeus; endoscopy; hypertrophy; surgical stapler; Zenker's diverticulum ID ZENKERS DIVERTICULUM; HYPOPHARYNGEAL DIVERTICULA; MANAGEMENT; ESOPHAGODIVERTICULOSTOMY; CO2-LASER; SURGERY AB Objectives: We directly compared endoscopic carbon dioxide (CO2) laser and stapler treatment methods for both cricopharyngeal hypertrophy (CPH) and Zenker's diverticulum (ZD). Methods: We performed a single-institution retrospective chart review of 153 patients who underwent either CO2 laser assisted or stapler-assisted endoscopic cricopharyngeal myotomy (CPM). Results: Isolated CPH was more likely to be treated with the CO2 laser than by stapler techniques. The ZD pouch size decreased significantly after surgery in both laser (p = 0.04) and stapler (p = 0.008) groups. The average duration of the procedure for CPM was longer for the laser than for the stapler (p = 0.01). Both techniques were successful when used in revision procedures. The overall complication rates were not statistically significantly different. Laser surgery trended toward a higher rate of major complications (2.4% versus 0%). Symptomatic recurrence was more likely after stapler surgery (p = 0.002). The rates of revision surgery were similar in the two groups (3.3% for laser and 4.3% for stapler). Conclusions: In the treatment of isolated CPH or ZD, stapler-assisted endoscopic surgery results in a shorter operative time, whereas laser-assisted CPM results in a decreased incidence of symptomatic recurrence. C1 [Pollei, Taylor R.; Hinni, Michael L.; Hayden, Richard E.; Lott, David G.; Mors, Matthew B.] Mayo Clin Arizona, Dept Otolaryngol Head & Neck Surg, Phoenix, AZ USA. RP Pollei, TR (reprint author), 5777 E Mayo Blvd, Phoenix, AZ 85054 USA. CR Altman JI, 2005, ANN OTO RHINOL LARYN, V114, P347 Bock JM, 2011, ANN OTO RHINOL LARYN, V120, P796 Bonafede JP, 1997, LARYNGOSCOPE, V107, P720, DOI 10.1097/00005537-199706000-00004 Chang CWD, 2004, LARYNGOSCOPE, V114, P519, DOI 10.1097/00005537-200403000-00025 Chang CWD, 2005, ANN OTO RHINOL LARYN, V114, P897 Chang CY, 2003, LARYNGOSCOPE, V113, P957, DOI 10.1097/00005537-200306000-00009 COLLARD JM, 1993, ANN THORAC SURG, V56, P573 DOHLMAN G, 1960, ARCHIV OTOLARYNGOL, V71, P744 Dohlman G., 1951, P 4 INT C OT LOND 19, V2, P715 Fama AF, 2009, LARYNGOSCOPE, V119, P1265, DOI 10.1002/lary.20247 Halvorson DJ, 1998, ENDOSCOPY, V30, P46, DOI 10.1055/s-2007-993729 Ho AS, 2011, ANN OTO RHINOL LARYN, V120, P33 Hoffman M, 2003, ANN OTO RHINOL LARYN, V112, P202 ISHIOKA S, 1995, ENDOSCOPY, V27, P433, DOI 10.1055/s-2007-1005736 KUHN FA, 1992, LARYNGOSCOPE, V102, P946, DOI 10.1288/00005537-199208000-00017 MARTINHIRSCH DP, 1993, J LARYNGOL OTOL, V107, P723 Miller FR, 2006, LARYNGOSCOPE, V116, P1608, DOI 10.1097/01.mlg.0000233508.06499.41 Mortensen M, 2010, LARYNGOSCOPE, V120, P17, DOI 10.1002/lary.20657 Mosher HP, 1917, SURG GYNECOL OBSTET, V25, P175 Parameswaran MS, 2002, ANN OTO RHINOL LARYN, V111, P871 Peracchia A, 1998, ARCH SURG-CHICAGO, V133, P695, DOI 10.1001/archsurg.133.7.695 Pitman M, 2009, LARYNGOSCOPE, V119, P45, DOI 10.1002/lary.20032 Scher RL, 1996, LARYNGOSCOPE, V106, P951, DOI 10.1097/00005537-199608000-00007 VANOVERBEEK JJM, 1994, ANN OTO RHINOL LARYN, V103, P178 VANOVERBEEK JJM, 1984, ANN OTO RHINOL LARYN, V93, P34 Veenker Elizabeth, 2003, Curr Opin Otolaryngol Head Neck Surg, V11, P160, DOI 10.1097/00020840-200306000-00006 Verhaegen VJO, 2011, HEAD NECK-J SCI SPEC, V33, P154, DOI 10.1002/hed.21413 Wheeler WI, 1886, DUBLIN J MED SCI, V82, P349 Whited C, 2012, LARYNGOSCOPE, V122, P1297, DOI 10.1002/lary.23251 NR 29 TC 1 Z9 1 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD SEP PY 2013 VL 122 IS 9 BP 568 EP 574 PG 7 WC Otorhinolaryngology SC Otorhinolaryngology GA 220RE UT WOS:000324603800006 PM 24224400 ER PT J AU Berg, EE Sobol, SE Jacobs, I AF Berg, Eric E. Sobol, Steven E. Jacobs, Ian TI Laryngeal Obstruction by Cervical and Endolaryngeal Lymphatic Malformations in Children: Proposed Staging System and Review of Treatment SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE airway; lymphangioma; lymphatic malformation ID HEAD; NECK; SCLEROTHERAPY; INFANTS; TONGUE AB Objectives: We review and stage a series of congenital lymphatic malformations (LMs) that caused laryngeal obstruction according to a proposed staging system, review the treatment modalities utilized, and correlate the stage of disease with clinical outcomes and tracheotomy statuses. Methods: We present a detailed description of the clinical presentation, management approach, and clinical outcome and tracheotomy status of a series of patients with laryngeal obstruction by LMs. A 4-part staging system (stages I to IV) for congenital LMs obstructing the larynx, based upon our clinical experience, is proposed. The patients were retrospectively reviewed and staged according to the proposed system, and clinical management and outcomes were correlated with the stage of disease. Results: We identified 16 patients with laryngeal obstruction by LMs. Eighty-one percent (13 of 16) received sclerotherapy, and 50% (8 of 16) underwent operative excision or debridement. Forty percent (2 of 5) of stage I lesions, 75% (3 of 4) of stage II lesions, 100% (4 of 4) of stage La lesions, and 100% (3 of 3) of stage IV lesions were in patients who required tracheotomy. All patients who had stage I and II lesions and required tracheotomy have been decannulated, whereas only 2 of the 4 patients with stage III lesions and no patients with stage IV lesions have been successfully decannulated. Conclusions: Lymphatic malformations obstructing the larynx require a careful and often staged management approach. A proposed staging system helps to predict the need for tracheotomy and the likelihood of long-term tracheotomy dependence. C1 [Berg, Eric E.; Sobol, Steven E.; Jacobs, Ian] Childrens Hosp Philadelphia, Div Otolaryngol, Philadelphia, PA 19104 USA. RP Berg, EE (reprint author), Univ Texas SW Med Ctr Dallas, Childrens Med Ctr, 2350 Stemmons Freeway,ENT F6-218, Dallas, TX 75207 USA. CR Acevedo JL, 2008, OTOLARYNG HEAD NECK, V138, P418, DOI 10.1016/j.otohns.2007.11.018 Azizkhan RG, 2006, J PEDIATR SURG, V41, P1279, DOI 10.1016/j.jpedsurg.2006.03.044 Bai Y, 2009, J ORAL MAXIL SURG, V67, P251, DOI 10.1016/j.joms.2008.06.046 Bloom David C, 2004, Curr Opin Otolaryngol Head Neck Surg, V12, P500, DOI 10.1097/01.moo.0000143971.19992.2d Boardman SJ, 2010, ARCH OTOLARYNGOL, V136, P270, DOI 10.1001/archoto.2010.6 Churchill P, 2011, J PEDIATR SURG, V46, P912, DOI 10.1016/j.jpedsurg.2011.02.027 COHEN SR, 1986, ANN OTO RHINOL LARYN, V95, P1 DESERRES LM, 1995, ARCH OTOLARYNGOL, V121, P577 Grimmer JF, 2006, ARCH OTOLARYNGOL, V132, P1251, DOI 10.1001/archotol.132.11.1251 Hamoir M, 2001, HEAD NECK-J SCI SPEC, V23, P326, DOI 10.1002/hed.1039 Jamal N, 2012, INT J PEDIATR OTORHI, V76, P1127, DOI 10.1016/j.ijporl.2012.04.015 MULLIKEN JB, 1982, PLAST RECONSTR SURG, V69, P412, DOI 10.1097/00006534-198203000-00002 Perkins JA, 2010, OTOLARYNG HEAD NECK, V142, P795, DOI 10.1016/j.otohns.2010.02.026 Richter G. T., 2012, INT J PEDIAT, V2012, DOI [10.1155/2012/645678, DOI 10.1155/2012/645678.EPUB] Smith MC, 2009, LARYNGOSCOPE, V119, P107, DOI 10.1002/lary.20041 Swetman GL, 2012, NEW ENGL J MED, V366, P384, DOI 10.1056/NEJMc1112482 Wiegand S, 2009, ARCH OTOLARYNGOL, V135, P976, DOI 10.1001/archoto.2009.131 Wittekindt C, 2006, INT J PEDIATR OTORHI, V70, P1205, DOI 10.1016/j.ijporl.2005.12.013 Zhou Q, 2011, ORAL ONCOL, V47, P1105, DOI 10.1016/j.oraloncology.2011.08.001 NR 19 TC 1 Z9 1 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD SEP PY 2013 VL 122 IS 9 BP 575 EP 581 PG 7 WC Otorhinolaryngology SC Otorhinolaryngology GA 220RE UT WOS:000324603800007 PM 24224401 ER PT J AU Banga, R Doshi, J Child, A Pendleton, E Reid, A McDermott, AL AF Banga, Rupan Doshi, Jayesh Child, Anne Pendleton, Elizabeth Reid, Andrew McDermott, Ann-Louise TI Bone-Anchored Hearing Devices in Children With Unilateral Conductive Hearing Loss: A Patient-Carer Perspective SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE conductive hearing loss; pediatrics; prosthesis implantation; quality of life; questionnaire; unilateral hearing loss ID QUALITY-OF-LIFE; BENEFIT INVENTORY; AID; DEAFNESS; SATISFACTION; IMPAIRMENT; EXPERIENCE AB Objectives: We sought to determine the outcome of implantation of a bone-anchored hearing device in children with unilateral conductive hearing loss. Methods: A retrospective case note analysis was used in a tertiary referral pediatric hospital to study 17 consecutive cases of pediatric patients with unilateral conductive hearing loss who were fitted with a bone-anchored hearing device between 2005 and 2010. Results: The average age of the patients at the time of bone-anchored hearing device fitting was 10 years 6 months (range, 6 years 3 months to 16 years). Qualitative subjective outcome measures demonstrated benefit. The vast majority of patients reported improved social and physical functioning and improved quality of life. All 17 patients are currently using their bone-anchored hearing device on a daily basis after a follow-up of 6 months. Conclusions: This study has shown improved quality of life in children with unilateral hearing loss after implantation of their bone-anchored hearing device. There was a high degree of patient satisfaction and improvement in health status reported by children and/or carers. Bone-anchored hearing devices have an important role in the management of children with symptomatic unilateral hearing loss. Perhaps earlier consideration of a bone-anchored hearing device would be appropriate in selected cases. C1 [Banga, Rupan; Doshi, Jayesh; Child, Anne; Pendleton, Elizabeth; Reid, Andrew; McDermott, Ann-Louise] Birmingham Childrens Hosp, Dept Otolaryngol, Birmingham B4 6NH, W Midlands, England. RP Banga, R (reprint author), Birmingham Childrens Hosp, Dept Otolaryngol, Steelhouse Lane, Birmingham B4 6NH, W Midlands, England. CR Banga R, 2011, ADV OTO-RHINO-LARYNG, V71, P132, DOI 10.1159/000323711 Christensen L, 2010, ARCH OTOLARYNGOL, V136, P175, DOI 10.1001/archoto.2009.203 de Wolf MJF, 2010, OTOL NEUROTOL, V31, P766, DOI 10.1097/MAO.0b013e3181e3d740 de Wolf MJF, 2011, ARCH OTOLARYNGOL, V137, P130, DOI 10.1001/archoto.2010.252 Doshi J, 2010, INT J PEDIATR OTORHI, V74, P608, DOI 10.1016/j.ijporl.2010.03.002 Doshi J, 2013, OTOL NEUROTOL, V34, P100, DOI 10.1097/MAO.0b013e318277a3dd Dutt SN, 2002, J LARYNGOL OTOL, V116, P37 Dutt SN, 2002, J LARYNGOL OTOL, V116, P7 Entific, 2001, SEL CRIT EV FITT PRO HAKANSSON B, 1985, ACTA OTO-LARYNGOL, V100, P229, DOI 10.3109/00016488509104785 Kubba H, 2004, ANN OTO RHINOL LARYN, V113, P980 Kunst SJW, 2008, OTOL NEUROTOL, V29, P2, DOI 10.1097/mao.0b013e31815ee29a Lieu JEC, 2004, ARCH OTOLARYNGOL, V130, P524, DOI 10.1001/archotol.130.5.524 Martin TPC, 2010, CLIN OTOLARYNGOL, V35, P284, DOI 10.1111/j.1749-4486.2010.02177.x MYLANUS EAM, 1995, ARCH OTOLARYNGOL, V121, P421 Priwin C, 2007, INT J PEDIATR OTORHI, V71, P135, DOI 10.1016/j.ijporl.2006.09.014 Snik AFM, 2002, OTOL NEUROTOL, V23, P61, DOI 10.1097/00129492-200201000-00015 Tjellström A, 1994, Ear Nose Throat J, V73, P112 TJELLSTROM A, 1980, ACTA OTO-LARYNGOL, V89, P85, DOI 10.3109/00016488009127113 Tjellstrom A, 1989, ADV OTOLARYNGOL HEAD, V3, P39 Wazen JJ, 2003, OTOLARYNG HEAD NECK, V129, P248, DOI 10.1016/S0194-5998(03)00527-8 NR 21 TC 3 Z9 3 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD SEP PY 2013 VL 122 IS 9 BP 582 EP 587 PG 6 WC Otorhinolaryngology SC Otorhinolaryngology GA 220RE UT WOS:000324603800008 PM 24224402 ER PT J AU Zagolski, O AF Zagolski, Olaf TI Subacute Rhinitis in Infants: Gastroesophageal Reflux Must Be Considered SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE gastroesophageal reflux; GERD; infant; nose; rhinitis ID CHRONIC RHINOSINUSITIS; BIRTH COHORT; NEONATAL RHINITIS; ALLERGIC RHINITIS; 1ST YEAR; SYMPTOMS; CHILDREN; QUESTIONNAIRE; DISEASE; LIFE AB Objectives: The study sought to evaluate the influence of gastroesophageal reflux disease (GERD) and allergy on subacute rhinitis in infants. Methods: Mothers of 74 infants with subacute rhinitis completed the Infant Gastroesophageal Reflux Questionnaire Revised. Participants with GERD were randomized to undergo one of the following regimens for 10 days: use of fluorometholone nasal drops with positional and feeding changes; positional and feeding changes; or a placebo. Results: The daily amount of nasal secretion decreased by 75.9% (p < 0.001), the intensity of swallowing difficulty by 79.2% (p < 0.001), and the incidence of uneasiness by 92.0% (p < 0.001) in infants treated with nasal glucocorticoid and positional and feeding changes; and the percentage differences in the amount of nasal secretion (p < 0.001), feeding difficulty (p < 0.001), and uneasiness (p < 0.001) were greater than those in the group treated with positional and feeding changes. The infants treated with placebo did not improve. The influence of nasal allergy was nonsignificant. Conclusions: Gastroesophageal reflux disease might contribute to aggravation of subacute rhinitis in infants. C1 [Zagolski, Olaf] St John Grandes Hosp, Dept Otorhinolaryngol, Krakow, Poland. RP Zagolski, O (reprint author), Ul Dunin Wasowicza 20-2-9, PL-30112 Krakow, Poland. CR Barnes PJ, 2006, EUR RESPIR J, V27, P413, DOI 10.1183/09031936.06.00125404 Baumann D, 2009, CLIN EXP ALLERGY, V39, P1540, DOI 10.1111/j.1365-2222.2009.03306.x Chan KH, 2004, J PEDIATR-US, V144, P206, DOI 10.1016/j.jped.2003.11.009 CONTENCIN P, 1991, INT J PEDIATR OTORHI, V22, P249, DOI 10.1016/0165-5876(91)90079-Q De Amici M, 2008, ALLERGY ASTHMA PROC, V29, P74, DOI 10.2500/aap2008.29.3081 Durmus R, 2010, ACTA OTO-LARYNGOL, V130, P1053, DOI 10.3109/00016481003621546 Erickson E, 2010, LARYNGOSCOPE, V120, P1569, DOI 10.1002/lary.20983 Halstead LA, 1999, OTOLARYNG HEAD NECK, V120, P208, DOI 10.1016/S0194-5998(99)70408-0 Herr M, 2011, ALLERGY, V66, P214, DOI 10.1111/j.1398-9995.2010.02467.x Kern RC, 2008, AM J RHINOL, V22, P549, DOI 10.2500/ajr.2008.22.3228 KLEEMANN WJ, 1995, INT J LEGAL MED, V108, P85, DOI 10.1007/BF01369910 Kleinman L, 2006, CLIN GASTROENTEROL H, V4, P588, DOI 10.1016/j.cgh.2006.02.016 Leo G, 2010, Int J Immunopathol Pharmacol, V23, P24 Leraillez J, 2001, ARCH PEDIATRIE, V8, P214, DOI 10.1016/S0929-693X(00)00189-5 Loehrl TA, 2002, OTOLARYNG HEAD NECK, V126, P382, DOI 10.1067/mhn.2002.123857 McPherson V, 2005, J FAM PRACTICE, V54, P372 Nathan CAO, 1997, INT J PEDIATR OTORHI, V39, P59, DOI 10.1016/S0165-5876(96)01464-4 Nelson SP, 1997, ARCH PEDIAT ADOL MED, V151, P569 Orenstein Susan R, 2010, Curr Gastroenterol Rep, V12, P431, DOI 10.1007/s11894-010-0140-1 Orenstein SR, 1996, CLIN PEDIATR, V35, P607, DOI 10.1177/000992289603501201 Richer SL, 2008, AM J RHINOL, V22, P228, DOI 10.2500/ajr.2008.22.3162 Satdhabudha A, 2012, INT J PEDIATR OTORHI, V76, P583, DOI 10.1016/j.ijporl.2012.01.022 Semic-Jusufagic A, 2007, J ALLERGY CLIN IMMUN, V119, P930, DOI 10.1016/j.jaci.2006.12.639 TOLLEY NS, 1992, INT J PEDIATR OTORHI, V24, P253, DOI 10.1016/0165-5876(92)90023-I von Linstow ML, 2008, PEDIATR PULM, V43, P584, DOI 10.1002/ppul.20828 Wong IWY, 2010, AM J RHINOL ALLERGY, V24, P255, DOI 10.2500/ajra.2010.24.3490 NR 26 TC 0 Z9 0 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD SEP PY 2013 VL 122 IS 9 BP 588 EP 594 PG 7 WC Otorhinolaryngology SC Otorhinolaryngology GA 220RE UT WOS:000324603800009 PM 24224403 ER PT J AU Jo, SY Lee, N Hong, SM Jung, HH Chae, SW AF Jo, Sun-Young Lee, Naree Hong, Sung-Moon Jung, Hak Hyun Chae, Sung-Won TI Caffeic Acid Phenethyl Ester Inhibits Diesel Exhaust Particle-Induced Inflammation of Human Middle Ear Epithelial Cells Via NOX4 Inhibition SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE diesel; nicotinamide adenine dinucleotide phosphate oxidase; otitis media ID REACTIVE OXYGEN; NADPH OXIDASES; OTITIS-MEDIA; AIRWAY INFLAMMATION; CIGARETTE-SMOKE; LUNG; MECHANISM; IMMUNITY; SIGNAL; CAPE AB Objectives: Otitis media is one of the, most common diseases in pediatric populations. Recent research on its pathogenesis has focused on air pollution. Chronic exposure to particulate air pollution is associated with the impairment of middle ear function. However, the mechanisms and the underlying inhibitory pathways, especially in the human middle ear, remain unknown. Caffeic acid phenethyl ester (CAPE) is a biologically active ingredient of propolis, a product of honeybee hives, which has anti-oxidative and anti-inflammatory activities. The aim of this study was to evaluate the inhibitory effect of CAPE on diesel exhaust particle (DEP) induced inflammation of human middle ear epithelial cells and to determine the underlying pathway of the action of CAPE. Methods: The inflammatory damage caused by DEPs and the anti-inflammatory effects of CAPE were determined by measuring the levels of tumor necrosis factor a and nicotinamide adenine dinucleotide phosphate oxidase (NOX) 4 with real-time reverse transcription polymerase chain reaction and Western blot analysis. The oxidative stress induced by DEPs and the anti-oxidative effects of CAPE were directly evaluated by measuring reactive oxygen species production by use of flow cytometric analysis of 2',7'-dichlorofluorescein diacetate. The effects of CAPE were compared with those of N-acetyl-L-cysteine, which has anti-oxidative and anti-inflammatory effects. Results: Use of CAPE significantly inhibited DEP-induced up-regulation of tumor necrosis factor a and NOX4 expression in a dose- and time-dependent manner. The accumulation of reactive oxygen species induced by DEPs was decreased by pretreatment with CAPE. The anti-inflammatory and anti-oxidative effects of CAPE were similar to those of N-acetyl-L-cysteine. Conclusions: The inflammation induced by DEP is reduced by CAPE via the inhibition of NOX4 expression. These findings suggest that CAPE might be used as a therapeutic agent against DEP-induced inflammation of human middle ear epithelial cells. C1 [Jo, Sun-Young] Korea Univ, Coll Med, Div Brain Korea 21, Program Biomed Sci, Seoul 152703, South Korea. [Lee, Naree; Hong, Sung-Moon; Jung, Hak Hyun; Chae, Sung-Won] Korea Univ, Coll Med, Dept Otorhinolaryngol Head & Neck Surg, Seoul 152703, South Korea. RP Jo, SY (reprint author), Korea Univ, Coll Med, Dept Otorhinolaryngol Head & Neck Surg, Guro Hosp, 80 Guro Dong, Seoul 152703, South Korea. CR Amara N, 2007, AM J PHYSIOL-LUNG C, V293, pL170, DOI 10.1152/ajplung.00445.2006 Arsenijevic D, 2000, NAT GENET, V26, P435 Babbar N, 2006, CANCER RES, V66, P11125, DOI 10.1158/0008-5472.CAN-06-3174 Boldogh I, 2005, J CLIN INVEST, V115, P2169, DOI 10.1172/JCI24422 Brauer M, 2006, ENVIRON HEALTH PERSP, V114, P1414, DOI 10.1289/ehp.9089 Domagala-Kulawik J, 2008, J PHYSIOL PHARMACOL, V59, P19 Doner Fehmi, 2002, Journal of Basic and Clinical Physiology and Pharmacology, V13, P33 Drake IM, 1998, GUT, V42, P768 Geiszt M, 2006, CARDIOVASC RES, V71, P289, DOI 10.1016/j.cardiores.2006.05.004 Griendling KK, 2006, ANTIOXID REDOX SIGN, V8, P1443, DOI 10.1089/ars.2006.8.1443 GRUNBERGER D, 1988, EXPERIENTIA, V44, P230, DOI 10.1007/BF01941717 Kikuzaki H, 2002, J AGR FOOD CHEM, V50, P2161, DOI 10.1021/jf011348w Lambeth JD, 2004, NAT REV IMMUNOL, V4, P181, DOI 10.1038/nri1312 Maes T, 2010, RESP RES, V11, DOI 10.1186/1465-9921-11-7 Meyer AS, 1998, J AGR FOOD CHEM, V46, P1783, DOI 10.1021/jf9708960 Paravicini TM, 2008, DIABETES CARE, V31, pS170, DOI 10.2337/dc08-s247 Parlakpinar H, 2005, TOXICOLOGY, V207, P169, DOI 10.1016/j.tox.2004.08.024 Rovers MM, 2004, LANCET, V363, P465, DOI 10.1016/S0140-6736(04)15495-0 Rovers MM, 2008, VACCINE, V26, pG2, DOI 10.1016/j.vaccine.2008.11.005 Shao MXG, 2004, AM J PHYSIOL-LUNG C, V287, pL420, DOI 10.1152/ajplung.00019.2004 Song JJ, 2008, ACTA OTO-LARYNGOL, V128, P1303, DOI 10.1080/00016480801947082 Song JJ, 2012, INT J PEDIATR OTORHI, V76, P334, DOI 10.1016/j.ijporl.2011.12.003 TRENAM CW, 1991, BRIT J DERMATOL, V125, P325, DOI 10.1111/j.1365-2133.1991.tb14165.x Wichmann HE, 2007, INHAL TOXICOL, V19, P241, DOI 10.1080/08958370701498075 Wiseman H, 1996, BIOCHEM J, V313, P17 Zhang XC, 2003, AM J RESP CELL MOL, V28, P305, DOI 10.1165/rcmb.2002-0156OC NR 26 TC 2 Z9 2 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD SEP PY 2013 VL 122 IS 9 BP 595 EP 600 PG 6 WC Otorhinolaryngology SC Otorhinolaryngology GA 220RE UT WOS:000324603800010 PM 24224404 ER PT J AU O'Rourke, A Weinberger, P Morrison, M Conklin, J Postma, G AF O'Rourke, Ashli Weinberger, Paul Morrison, Michele Conklin, Jeffrey Postma, Gregory TI Topical Bethanechol for the Improvement of Esophageal Dysmotility: A Pilot Study SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article; Proceedings Paper CT Meeting of the American-Broncho-Esophagological-Association CY APR 18-19, 2012 CL San Diego, CA SP Amer Broncho Esophagol Assoc DE bethanechol; dysphagia; esophageal dysmotility; esophageal hypoperistalsis; high resolution manometry; ineffective esophageal motility ID MULTICHANNEL INTRALUMINAL IMPEDANCE; PRESSURE TOPOGRAPHY; MOTILITY ABNORMALITIES; HEALTHY-VOLUNTEERS; MOTOR FUNCTION; MANOMETRY; PERISTALSIS; CLASSIFICATION; SPHINCTER; CLEARANCE AB Objectives: We studied a case series to evaluate the effect of topical bethanechol chloride on esophageal function in individuals with ineffective esophageal motility. Methods: Five subjects with ineffective esophageal motility underwent high resolution esophageal manometry. Ten 5 mL liquid swallows were performed to establish a baseline. Five milligrams of topical bethanechol was then administered. After 10 minutes, the subjects completed 10 additional liquid swallows. This procedure was repeated with 10 mg of bethanechol in 4 subjects. Results: After administration of 5 mg of topical bethanechol, the mean (+/- SD) distal contractile integral, an index of esophageal contractility, increased from 178.3 +/- 83.1 mm Hg.s.cm to 272.3 +/- 216.9 mm Hg.s.cm (p = 0.69). The percentage of failed swallows decreased from 52.8% +/- 33.2% to 29.4% +/- 18.3% (p = 0.14). The percentage of peristaltic swallows increased from 28.0% +/- 26.8% to 67.2% +/- 15.3% (p = 0.04). The contractile front velocity was essentially unchanged. After administration of 10 mg of bethanechol, the distal contractile integral decreased from 349.3 +/- 371.0 mm Hg.s.cm to 261.8 +/- 293.5 mm Hg.s.cm (p = 0.72). The percentage of failed swallows increased from 57.5% +/- 37.7% to 66.8% +/- 24.9% (p = 0.46). The percentage of peristaltic swallows increased from 17.5% +/- 23.6% to 28.3% +/- 19.1% (p = 0.29). The contractile front velocity decreased from 11.6 +/- 5.2 cm/s to 4.9 +/- 3.0 cm/s (p = 0.32). No adverse side effects occurred. Conclusions: The results of this pilot study support the need for further investigation with larger sample sizes and dose escalation. C1 [O'Rourke, Ashli; Weinberger, Paul; Postma, Gregory] Georgia Regents Univ, Dept Otolaryngol Head & Neck Surg, Ctr Voice Airway & Swallowing Disorders, Augusta, GA USA. [Morrison, Michele] Naval Med Ctr Portsmouth, Dept Otolaryngol Head & Neck Surg, Portsmouth, VA USA. [Conklin, Jeffrey] Cedars Sinai Med Ctr, Esophageal Ctr Cedars Sinai, Los Angeles, CA 90048 USA. RP O'Rourke, A (reprint author), Med Univ S Carolina, Evelyn Trammell Inst Voice & Swallowing, 135 Rutledge Tower MSC 550, Charleston, SC 29425 USA. CR Agrawal A, 2007, J CLIN GASTROENTEROL, V41, P366, DOI 10.1097/01.mcg.0000225542.03880.68 Blonski W, 2009, J CLIN GASTROENTEROL, V43, P253, DOI 10.1097/MCG.0b013e318167b89d Bredenoord AJ, 2012, NEUROGASTROENT MOTIL, V24, P57, DOI 10.1111/j.1365-2982.2011.01834.x Bulsiewicz WJ, 2009, AM J GASTROENTEROL, V104, P2721, DOI 10.1038/ajg.2009.467 Conchillo JM, 2005, AM J GASTROENTEROL, V100, P2624, DOI 10.1111/j.1572-0241.2005.00303.x Dekel R, 2003, ALIMENT PHARM THERAP, V18, P1083, DOI 10.1046/j.1365-2036.2003.01772.x Di Stefano M, 2004, GASTROENTEROLOGY, V126, pA638 DODDS WJ, 1981, AM J PHYSIOL, V240, pG290 Fouad YM, 1999, AM J GASTROENTEROL, V94, P1464 GIDDA JS, 1986, AM J PHYSIOL, V251, pG779 Hammer Davita, 2005, Neonatal Netw, V24, P51 HOLLOWAY RH, 1986, GASTROENTEROLOGY, V90, P924 HUMPHRIES TJ, 1981, DIGEST DIS SCI, V26, P129, DOI 10.1007/BF01312229 KAHRILAS PJ, 1988, GASTROENTEROLOGY, V94, P73 Michalets EL, 2000, CLIN PHARMACOKINET, V39, P49, DOI 10.2165/00003088-200039010-00004 Pandolfino JE, 2009, NEUROGASTROENT MOTIL, V21, P796, DOI 10.1111/j.1365-2982.2009.01311.x Song CW, 1997, SCAND J GASTROENTERO, V32, P541, DOI 10.3109/00365529709025096 Spechler SJ, 2001, GUT, V49, P145, DOI 10.1136/gut.49.1.145 Tutuian R, 2004, AM J GASTROENTEROL, V99, P1011, DOI 10.1111/j.1572-0241.2004.30035.x NR 19 TC 0 Z9 0 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD AUG PY 2013 VL 122 IS 8 BP 481 EP 486 PG 6 WC Otorhinolaryngology SC Otorhinolaryngology GA 202CV UT WOS:000323192000001 PM 24027856 ER PT J AU Syms, CA Grantham, ML AF Syms, Charles A., III Grantham, Mary Lou TI Otologic Iontophoresis: A No-Papoose Technique SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE iontophoresis; myringotomy; pain; pressure equalization tube; topical anesthesia; tympanic membrane ID TYMPANIC MEMBRANE; LOCAL ANESTHESIA; MYRINGOTOMY; CHILDREN; EAR AB Objectives: We describe a new iontophoresis solution, used in conjunction with a new iontophoresis system for achieving anesthesia of the tympanic membrane before myringotomy and insertion of pressure equalization tubes in an office setting. Methods: We selected 50 patients (86 ears) who met standard indications for myringotomy only or myringotomy and pressure equalization tube insertion for a single-site consecutive series trial (Institutional Review Board-approved; informed consent and assent) in the authors' clinical practice. Topical anesthesia was obtained with a new US Food and Drug Administration-cleared iontophoresis system (Acclarent, Inc, Menlo Park, California) and a novel iontophoresis solution mixture. The Wong-Baker FACES Pain Rating Scale was used to assess the tolerability of the iontophoresis system with the new solution and of the otologic procedure after topical anesthesia was obtained. Results: Iontophoresis success was obtained in 78 of 86 ears (90.7%). The average pain score for patients after iontophoresis was 1.07 on a 0-to-5 scale of increasing pain. The ear treatment was successful in 70 of 78 ears (89.7%). The average pain score for the surgical procedure was 1.19. Conclusions: This study demonstrates the safety and clinical effectiveness of the Acclarent iontophoresis system in conjunction with a new iontophoresis solution for anesthesia of the tympanic membrane in an office setting. This solution and device enable otologic procedures in children as young as 12 months of age without the use of a papoose, premedication, or general anesthesia. C1 [Syms, Charles A., III; Grantham, Mary Lou] Univ Texas Hlth Sci Ctr San Antonio, Ear Med Grp, San Antonio, TX 78229 USA. [Syms, Charles A., III] Univ Texas Hlth Sci Ctr San Antonio, Dept Otolaryngol Head & Neck Surg, San Antonio, TX 78229 USA. RP Syms, CA (reprint author), Ear Med Grp, 21 Spurs Ln,Suite 100, San Antonio, TX 78240 USA. FU Acclarent, Inc, Menlo Park, California FX From Ear Medical Group (both authors) and the Department of Otolaryngology-Head and Neck Surgery, University of Texas Health Science Center at San Antonio (Syms), San Antonio, Texas. Financial and administrative support for this study was given by Acclarent, Inc, Menlo Park, California. CR Albrecht W., 1911, ARCH OHRENHEILKUNDE, V85, P198, DOI 10.1007/BF02114916 Bancroft J W, 1992, J Vasc Interv Radiol, V3, P107, DOI 10.1016/S1051-0443(92)72200-3 Brodsky L, 1999, LARYNGOSCOPE, V109, P2009, DOI 10.1097/00005537-199912000-00022 CARRASCO VN, 1993, LARYNGOSCOPE, V103, P92 COMEAU M, 1973, ARCH OTOLARYNGOL, V98, P114 ECHOLS DF, 1975, ARCH OTOLARYNGOL, V101, P418 EPLEY JM, 1977, ARCH OTOLARYNGOL, V103, P358 Hicks CL, 2001, PAIN, V93, P173, DOI 10.1016/S0304-3959(01)00314-1 SCHLEUNI.AJ, 1974, T AM ACAD OPHTHALMOL, V78, P453 STORRS LA, 1968, LARYNGOSCOPE, V78, P834, DOI 10.1288/00005537-196805000-00014 Tomlinson D, 2010, PEDIATRICS, V126, pE1168, DOI 10.1542/peds.2010-1609 Wong D L, 1988, Pediatr Nurs, V14, P9 NR 12 TC 1 Z9 1 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD AUG PY 2013 VL 122 IS 8 BP 487 EP 491 PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA 202CV UT WOS:000323192000002 PM 24027857 ER PT J AU Kirch, S Gegg, R Johns, MM Rubin, AD AF Kirch, Suzanne Gegg, Ryan Johns, Michael M. Rubin, Adam D. TI Globus Pharyngeus: Effectiveness of Treatment With Proton Pump Inhibitors and Gabapentin SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE gabapentin; globus pharyngeus; neuropathy; proton pump inhibitor; reflux; throat pain ID GASTROESOPHAGEAL-REFLUX; LARYNGOPHARYNGEAL REFLUX; POSITION STATEMENT; UNITED-KINGDOM; MANAGEMENT; DIAGNOSIS; PERSPECTIVE; NEUROPATHY; DISORDERS; SENSATION AB Objectives: This study was performed to investigate the effectiveness of treatment of globus pharyngeus with proton pump inhibitors, gabapentin, or both. Methods: The subjects all presented with globus pharyngeus during the years 2006 to 2011. The inclusion criteria included a chief (primary) complaint of globus pharyngeus; a trial of proton pump inhibitor therapy for at least 2 months and/or a trial of gabapentin for at least 2 weeks; and at least 1 follow-up visit. We reviewed 331 charts; 87 patients met the criteria. The response to treatment was graded as none, partial, or complete. Results: Seventy-seven percent of all patients had improvement. Sixty-seven percent of patients had a partial or complete response from aggressive reflux management. Sixty-six percent of patients who had a trial of gabapentin reported improvement. Eight of 14 patients who did not improve with aggressive reflux management improved with gabapentin. Conclusions: A majority of patients with globus pharyngeus can be helped by treating reflux or neuralgia. A trial of gabapentin should be considered for patients who do not respond or only partially respond to reflux management. C1 [Kirch, Suzanne; Gegg, Ryan; Rubin, Adam D.] Lakeshore Ear Nose & Throat Ctr, Lakeshore Profess Voice Ctr, St Clair Shores, MI 48081 USA. [Johns, Michael M.] Emory Univ, Sch Med, Emory Voice Ctr, Dept Otolaryngol Head & Neck Surg, Atlanta, GA USA. RP Rubin, AD (reprint author), Lakeshore Ear Nose & Throat Ctr, 21000 E 12 Mile Rd,Ste 111, St Clair Shores, MI 48081 USA. CR Amin MR, 2008, OTOLARYNG HEAD NECK, V138, P411, DOI 10.1016/j.otohns.2007.12.032 Amin MR, 2001, AM J OTOLARYNG, V22, P251, DOI 10.1053/ajot.2001.24823 [Anonymous], 2011, PFIZ PROD MON Backonja MM, 2004, PAIN MED, V5, pS28, DOI 10.1111/j.1526-4637.2004.04020.x BATCH AJG, 1988, J LARYNGOL OTOL, V102, P227, DOI 10.1017/S0022215100104591 Burns P, 2007, J LARYNGOL OTOL, V121, P242, DOI 10.1017/S0022215106002465 Choudhuri I, 2007, EYE, V21, P1194, DOI 10.1038/sj.eye.6702434 Corso MJ, 1998, DIGEST DIS SCI, V43, P1513, DOI 10.1023/A:1018862814873 Galmiche JP, 2006, GASTROENTEROLOGY, V130, P1459, DOI 10.1053/j.gastro.2005.08.060 Harar RPS, 2004, J LARYNGOL OTOL, V118, P522 Khalil HS, 2008, CURR OPIN OTOLARYNGO, V16, P516, DOI 10.1097/MOO.0b013e328313bb7f Khalil HS, 2011, CLIN OTOLARYNGOL, V36, P388, DOI 10.1111/j.1749-4486.2011.02326.x Koufman JA, 2002, OTOLARYNG HEAD NECK, V127, P32, DOI 10.1067/mhn.2002.125760 Lee B, 2005, ANN OTO RHINOL LARYN, V114, P253 Malcomson K G, 1968, J Laryngol Otol, V82, P219, DOI 10.1017/S0022215100068687 Mamede RCM, 2004, OTOLARYNG HEAD NECK, V131, P378, DOI 10.1016/j.otohns.2004.02.040 Mathew NT, 2001, HEADACHE, V41, P119, DOI 10.1046/j.1526-4610.2001.111006119.x Moayyedi P, 2012, NAT REV GASTRO HEPAT, V9, P132, DOI 10.1038/nrgastro.2011.272 MOLOY PJ, 1982, ARCH OTOLARYNGOL, V108, P740 Morrison M, 1999, J VOICE, V13, P447, DOI 10.1016/S0892-1997(99)80049-6 Norris BK, 2010, ANN OTO RHINOL LARYN, V119, P188 Purcell J., 1707, TREATISE VAPOURS HYS Reavis KM, 2004, ANN SURG, V239, P849, DOI 10.1097/01.sla.0000128303.05898.ee Remacle M, 2008, CURR OPIN OTOLARYNGO, V16, P511, DOI 10.1097/MOO.0b013e328313bb94 ROWLEY H, 1995, LARYNGOSCOPE, V105, P1118, DOI 10.1288/00005537-199510000-00019 Webb CJ, 2000, CLIN OTOLARYNGOL, V25, P566, DOI 10.1046/j.1365-2273.2000.00386.x WILSON JA, 1987, CLIN OTOLARYNGOL, V12, P271, DOI 10.1111/j.1365-2273.1987.tb00201.x NR 27 TC 2 Z9 2 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD AUG PY 2013 VL 122 IS 8 BP 492 EP 495 PG 4 WC Otorhinolaryngology SC Otorhinolaryngology GA 202CV UT WOS:000323192000003 PM 24027858 ER PT J AU Malinvaud, D Mukundan, S Crevier-Buchman, L Bonfils, P Laccourreye, O AF Malinvaud, David Mukundan, Subramanian Crevier-Buchman, Lise Bonfils, Pierre Laccourreye, Ollivier TI Glottic Bamboo Nodules From Systemic Lupus Erythematosus SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE autoimmune disease; bamboo nodule; glottis; lupus ID AUTOIMMUNE-DISEASE; MANIFESTATION; HOARSENESS AB Bamboo nodules of the glottis are of late being described as a distinct entity seen in patients with autoimmune diseases. We report the symptoms, clinical features, and management of a case of bamboo nodules of the glottis in a patient with systemic lupus erythematosus. We discuss the pathogenesis and management of this condition on the basis of a review of the medical literature. C1 [Malinvaud, David; Mukundan, Subramanian; Crevier-Buchman, Lise; Bonfils, Pierre; Laccourreye, Ollivier] Univ Paris 05, Dept Otorhinolaryngol Head & Neck Surg, Sorbonne Paris Cite, HEGP,AP HP, Paris, France. RP Laccourreye, O (reprint author), HEGP, Dept Otorhinolaryngol Head & Neck Surg, 20-40 Rue Leblanc, F-75015 Paris, France. FU Progres 2000 Association FX From the Department of Otorhinolaryngology-Head and Neck Surgery, Universite Paris Descartes Sorbonne Paris Cite, HEGP, AP-HP, Paris, France. Supported by the Progres 2000 Association. CR Charuvanij S, 2009, PEDIATR RHEUMATOL, V7, DOI 10.1186/1546-0096-7-19 Hilgert E, 2008, J VOICE, V22, P343, DOI 10.1016/j.jvoice.2006.10.009 Hosako Y, 1993, LARYNX JAPAN, V6, P171 Hosako-Naito Y, 1999, ORL J OTO-RHINO-LARY, V61, P151, DOI 10.1159/000027661 Hughes M, 2009, MOD RHEUMATOL, V19, P441, DOI 10.1007/s10165-009-0178-9 Karim A, 2002, CHEST, V121, P990, DOI 10.1378/chest.121.3.990 Lee JH, 2008, AM J PHYS MED REHAB, V87, P68, DOI 10.1097/PHM.0b013e31815b669e Li LS, 2010, J VOICE, V24, P738, DOI 10.1016/j.jvoice.2009.06.003 McNellis EL, 1997, OTOLARYNG HEAD NECK, V116, P107, DOI 10.1016/S0194-5998(97)70359-0 Murano E, 2001, J VOICE, V15, P441, DOI 10.1016/S0892-1997(01)00044-3 Perouse R, 2001, Rev Laryngol Otol Rhinol (Bord), V122, P299 Ramos Hugo Valter Lisboa, 2005, Braz J Otorhinolaryngol, V71, P499 Sanz L, 2012, J VOICE, V26, P148, DOI 10.1016/j.jvoice.2011.02.003 SMITH RR, 1976, LARYNGOSCOPE, V86, P734, DOI 10.1288/00005537-197605000-00016 TEITEL AD, 1992, SEMIN ARTHRITIS RHEU, V22, P203, DOI 10.1016/0049-0172(92)90020-E Tsunoda K, 1996, J LARYNGOL OTOL, V110, P478 Wallace DJ, 1997, ARTHRITIS ALLIED CON, P1319 NR 17 TC 0 Z9 0 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD AUG PY 2013 VL 122 IS 8 BP 496 EP 499 PG 4 WC Otorhinolaryngology SC Otorhinolaryngology GA 202CV UT WOS:000323192000004 PM 24027859 ER PT J AU Gristwood, RE Venables, WN AF Gristwood, Ronald Edward Venables, William Norman TI Analysis of Long-Term Hearing Gains After Stapes Surgery With Piston Reconstruction for Otosclerosis SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE hearing gain; otosclerosis; piston reconstruction; stapes surgery ID OVAL WINDOW NICHE; SMALL FENESTRA; TOTAL STAPEDECTOMY; FOLLOW-UP; STAPEDOTOMY; OPERATION AB Objectives: We sought to assess the postoperative hearing gains at individual frequencies after stapes surgery with piston reconstruction for clinical otosclerosis. Methods: We analyzed the air conduction (AC) hearing gains at various audiometric frequencies in a sample of 1,168 stapes procedures with piston reconstruction performed on 911 strictly consecutive patients by one surgeon between 1963 and 1979. Assiduous follow-up of patients was attempted for at least 10 years. The audiometric results over time were stored for computer analysis. Results: The mean AC gain over the speech frequencies (0.5, 1, 2, and 3 kHz) was 35.5 dB at 1 year after operation, and the rate of deterioration over the next 19 years was 0.58 dB/y. Conclusions: The picture to emerge from the analysis is clear. The mean AC gain is maximal at nearly 40 dB for the audiometric frequencies of 0.25, 0.5, and 1 kHz. The mean AC gain at any given time after operation decreases with increasing frequency, at least for frequencies of >= 1 kHz. For any frequency there is, with few exceptions, a significant decrease in the AC gain from one time period to the next. C1 [Gristwood, Ronald Edward] Royal Adelaide Hosp, Dept Otolaryngol, Adelaide, SA 5000, Australia. [Venables, William Norman] Univ Adelaide, Dept Stat, Adelaide, SA 5001, Australia. RP Gristwood, RE (reprint author), Toynbee Clin, 12 Walter St, Adelaide, SA 5006, Australia. CR Aarnisalo AA, 2003, OTOL NEUROTOL, V24, P567, DOI 10.1097/00129492-200307000-00006 BAILEY HAT, 1981, LARYNGOSCOPE, V91, P1308 Carhart R, 1962, OTOSCLEROSIS, P175 CREMERS CWRJ, 1991, ANN OTO RHINOL LARYN, V100, P959 FISCH U, 1982, AM J OTOL, V4, P112 GINSBERG IA, 1981, LARYNGOSCOPE, V91, P87 GOLDENBERG RA, 1995, AM J OTOL, V16, P128 Gore SM, 1982, STAT PRACTICE Gristwood R E, 1969, J Otolaryngol Soc Aust, V2, P39 Gristwood RE, 2011, ANN OTO RHINOL LARYN, V120, P363 Gristwood RE, 1990, J OTOLARYNGOL SOC AU, V6, P176 Gristwood RE, 1981, THESIS U EDINBURGH E Gristwood RE, 2008, ANN OTO RHINOL LARYN, V117, P569 GRISTWOOD RE, 1975, J LARYNGOL OTOL, V89, P1185, DOI 10.1017/S0022215100081573 Linder T, 2009, ENTOMOL NEWS, V17, P152 McGee TM, 1962, OTOSCLEROSIS, P489 MCGEE TM, 1981, ANN OTO RHINOL LARYN, V90, P633 PLATH P, 1992, HNO, V40, P52 SCHUKNEC.HF, 1969, NEW ENGL J MED, V280, P1154, DOI 10.1056/NEJM196905222802105 SHEA JJ, 1962, ARCHIV OTOLARYNGOL, V76, P516 SHEA J J Jr, 1958, Ann Otol Rhinol Laryngol, V67, P932 SMYTH GDL, 1978, ANN OTO RHINOL LARYN, V87, P3 SOMERS T, 1994, ANN OTO RHINOL LARYN, V103, P945 Venables WN, 1991, J OTOLARYNGOL SOC AU, V6, P451 Vincent R, 2006, OTOL NEUROTOL, V27, pS25, DOI 10.1097/01.mao.0000235311.80066.df Yung M, 2007, ADV OTO-RHINO-LARYNG, V65, P335, DOI 10.1159/000098856 NR 26 TC 0 Z9 0 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD AUG PY 2013 VL 122 IS 8 BP 500 EP 510 PG 11 WC Otorhinolaryngology SC Otorhinolaryngology GA 202CV UT WOS:000323192000005 PM 24027860 ER PT J AU Merrill, RM Tanner, K Merrill, JG McCord, MD Beardsley, MM Steele, BA AF Merrill, Ray M. Tanner, Kristine Merrill, Joseph G. McCord, Matthew D. Beardsley, Melissa M. Steele, Brittanie A. TI Voice Symptoms and Voice-Related Quality of Life in College Students SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE aging and health; quality of life; voice disorder ID GENERAL-POPULATION; DYSPHONIC PATIENTS; HEALTH SURVEY; DISORDERS; IMPACT; RELIABILITY; PERFORMANCE; PREVALENCE; HYDRATION; TEACHERS AB Objectives: The purpose of this study was to examine the prevalence of voice disorders in college students and their effect on the students as shown by quality-of-life indicators. Methods: A cross-sectional survey was completed by 545 college students in 2012. The survey included 10 questions from the Voice-Related Quality of Life (V-RQOL), selected voice symptoms, and quality-of-life indicators of functional health and well-being based on the Short Form 36-item Health Survey (SF-36). Results: Twenty-nine percent of the college students (mean age, 22.7 years) reported a history of a voice disorder. Hoarseness was the most prevalent voice symptom, but was not correlated with V-RQOL scores. A wobbly or shaky voice, throat dryness, vocal fatigue, and vocal effort explained a significant amount of variance on the social-emotional and physical domains of the V-RQOL index (p < 0.05). Voice symptoms limited emotional and physical functioning as indicated by SF-36 scores. Conclusions: Voice disorders significantly influence psychosocial and physical functioning in college students. These findings have important implications for voice-care services in this population. C1 [Merrill, Ray M.; Merrill, Joseph G.; McCord, Matthew D.; Beardsley, Melissa M.; Steele, Brittanie A.] Brigham Young Univ, Dept Hlth Sci, Provo, UT 84602 USA. [Tanner, Kristine] Brigham Young Univ, Dept Commun Disorders, Provo, UT 84602 USA. RP Merrill, RM (reprint author), Brigham Young Univ, Dept Hlth Sci, 229 A Richards Bldg, Provo, UT 84602 USA. CR American Speech- Language- Hearing Association, 1993, DEF COMM DIS VAR Angelillo M, 2009, J Prev Med Hyg, V50, P26 Behlau M, 2007, FOLIA PHONIATR LOGO, V59, P286, DOI 10.1159/000108335 Benninger MS, 1998, J VOICE, V12, P540, DOI 10.1016/S0892-1997(98)80063-5 Cohen SM, 2006, ANN OTO RHINOL LARYN, V115, P128 Eadie TL, 2010, J VOICE, V24, P564, DOI 10.1016/j.jvoice.2008.12.005 Eadie TL, 2007, ANN OTO RHINOL LARYN, V116, P695 George D, 2003, SPSS WINDOWS STEP ST, V4th Hamdan AL, 2007, J VOICE, V21, P495, DOI 10.1016/j.jvoice.2006.01.009 Hapner E, 2012, J VOICE, V26, P201, DOI 10.1016/j.jvoice.2011.01.003 Hogikyan ND, 1999, J VOICE, V13, P557, DOI 10.1016/S0892-1997(99)80010-1 Kline P, 1999, HDB PSYCHOL TESTING Krischke S, 2005, J VOICE, V19, P132, DOI 10.1016/j.jvoice.2004.01.007 Lee M, 2005, CLIN OTOLARYNGOL, V30, P357, DOI 10.1111/j.1365-2273.2005.01022.x Lenderking WR, 2003, VALUE HEALTH, V6, P560, DOI 10.1046/j.1524-4733.2003.65243.x MCHORNEY CA, 1994, MED CARE, V32, P40, DOI 10.1097/00005650-199401000-00004 Merrill RM, 2011, LARYNGOSCOPE, V121, P2004, DOI 10.1002/lary.21895 Murry T, 2000, OTOLARYNG CLIN N AM, V33, P905, DOI 10.1016/S0030-6665(05)70251-6 Nichol KL, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009548 Piwowarczyk TC, 2012, J VOICE, V26, P194, DOI 10.1016/j.jvoice.2011.02.006 Ramig LO, 1998, J SPEECH LANG HEAR R, V41, pS101 RAND Corporation, MED OUTC STUD 36 IT Roy N, 2007, LARYNGOSCOPE, V117, P628, DOI 10.1097/MLG.0b013e3180306da1 Roy N, 2004, J SPEECH LANG HEAR R, V47, P281, DOI 10.1044/1092-4388(2004/023) Roy N, 2004, J SPEECH LANG HEAR R, V47, P542, DOI 10.1044/1092-4388(2004/042) Roy N, 2005, LARYNGOSCOPE, V115, P1988, DOI 10.1097/01.mlg.0000179174.32345.41 Schwartz SR, 2009, OTOLARYNG HEAD NECK, V141, pS1, DOI 10.1016/j.otohns.2009.06.744 Sivasankar M, 2002, J VOICE, V16, P172, DOI 10.1016/S0892-1997(02)00087-5 Solomon NP, 2000, J VOICE, V14, P341 VERDOLINI K, 1994, J SPEECH HEAR RES, V37, P1001 WARE JE, 1994, INT J MENT HEALTH, V23, P49 Ware JE, 1993, SF 36 HLTH SURVEY MA NR 32 TC 0 Z9 0 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD AUG PY 2013 VL 122 IS 8 BP 511 EP 519 PG 9 WC Otorhinolaryngology SC Otorhinolaryngology GA 202CV UT WOS:000323192000006 PM 24027861 ER PT J AU Celis-Aguilar, E Lassaletta, L Roda, JM Gavilan, J AF Celis-Aguilar, Erika Lassaletta, Luis Roda, Jose M. Gavilan, Javier TI End-to-Side Interposed Donor Grafting as a Facial Nerve Reinforcement Technique After Vestibular Schwannoma Surgery SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE end-to-side neurorrhaphy; facial paralysis; facial reanimation technique; nerve graft; translabyrinthine surgery; vestibular schwannoma ID ACOUSTIC NEUROMA; CEREBELLOPONTINE ANGLE; NEURORRHAPHY; REMOVAL; REPAIR; RECOVERY; OUTCOMES AB Objectives: This retrospective case review was performed to determine the facial function outcome of an end-to-side interposed donor grafting technique in patients who had a nonresponsive and partially injured facial nerve during a translabyrinthine approach for vestibular schwannoma resection. Methods: The study included patients with silent electrophysiological tests after partial injury of the facial nerve during translabyrinthine schwannoma resection surgery in a tertiary referral hospital. The patients underwent end-to-side interposed donor grafting as a facial nerve reinforcement technique, and we evaluated their facial function after 1 year of follow-up. Results: Four cases with intact preoperative facial function were included (3 men and 1 woman). All patients had a lack of electrical response from the facial nerve and partial anatomic injury after a translabyrinthine approach. An end-to-side interposed donor grafting technique was performed. The donor grafts used were the sural nerve (2 patients), superior vestibular nerve (1 patient), and greater auricular nerve (1 patient). All patients achieved a good House-Brackmann grade. Ocular adjuvant procedures wee performed in all patients. Conclusions: Immediate repair of the facial nerve with an interposed donor graft may provide better facial function in patients who have no electrical response from a partially injured facial nerve after vestibular schwannoma surgery. C1 [Celis-Aguilar, Erika] Independent Univ Sinaloa, Ctr Res & Educ Hlth Sci, Dept Otolaryngol, Culiacan, Mexico. [Lassaletta, Luis; Gavilan, Javier] Hosp La Paz, Inst Hlth Res IdiPAZ, Univ Sch Med, Dept Otolaryngol La Paz, Madrid 28046, Spain. [Roda, Jose M.] Univ Hosp, Dept Neurosurg La Paz, Madrid, Spain. RP Lassaletta, L (reprint author), Hosp La Paz, Serv ORL, P Castellana 261, Madrid 28046, Spain. CR ARRIAGA MA, 1992, AM J OTOL, V13, P356 BLOMSTEDT GC, 1994, NEUROSURGERY, V35, P364 Bontioti E, 2005, J PERIPHER NERV SYST, V10, P58, DOI 10.1111/j.1085-9489.2005.10109.x Brackmann DE, 2007, OTOLARYNG HEAD NECK, V136, P773, DOI 10.1016/j.otohns.2006.10.009 Falcioni M, 2003, OTOL NEUROTOL, V24, P486, DOI 10.1097/00129492-200305000-00022 Ferraresi S, 2006, J NEUROSURG, V104, P457, DOI 10.3171/jns.2006.104.3.457 Gidley PW, 1999, AM J OTOL, V20, P781 Grayeli AB, 2005, OTOL NEUROTOL, V26, P114, DOI 10.1097/00129492-200501000-00021 Hayashi A, 2008, EXP NEUROL, V211, P539, DOI 10.1016/j.expneurol.2008.02.031 House J, 2010, OTOLOGIC SURG, P591, DOI 10.1016/B978-1-4160-4665-3.00049-4 KING TT, 1993, J NEUROSURG, V78, P720, DOI 10.3171/jns.1993.78.5.0720 Lin V, 2009, OTOL NEUROTOL, V30, P408, DOI 10.1097/MAO.0b013e31819a8e26 May M., 2000, FACIAL NERVE, P571 Nakao Y, 2001, OTOL NEUROTOL, V22, P554, DOI 10.1097/00129492-200107000-00024 Nakatsuka H, 2002, J RECONSTR MICROSURG, V18, P509, DOI 10.1055/s-2002-33323 Ozmen OA, 2011, OTOL NEUROTOL, V32, P1341, DOI 10.1097/MAO.0b013e31822e952d Rivas A, 2011, OTOL NEUROTOL, V32, P826, DOI 10.1097/MAO.0b013e31821b0afd Samii M, 1994, ACTA NEUROCHIR WIEN, V130, P129 Samii M, 1997, NEUROSURGERY, V40, P684, DOI 10.1097/00006123-199704000-00006 Samii M, 2006, J NEUROSURG, V105, P920, DOI 10.3171/jns.2006.105.6.920 VITERBO F, 1994, PLAST RECONSTR SURG, V94, P1038, DOI 10.1097/00006534-199412000-00019 Viterbo F, 1998, Sao Paulo Med J, V116, P1808, DOI 10.1590/S1516-31801998000500005 Zhang F, 2002, MICROSURG, V22, P122, DOI 10.1002/micr.21736 NR 23 TC 0 Z9 0 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD AUG PY 2013 VL 122 IS 8 BP 520 EP 523 PG 4 WC Otorhinolaryngology SC Otorhinolaryngology GA 202CV UT WOS:000323192000007 PM 24027862 ER PT J AU Adelman, C Perez, R Sohmer, H AF Adelman, Cahtia Perez, Ronen Sohmer, Haim TI Effect on Auditory Threshold of Air and Water Pockets Bordering the Pathway Between Soft Tissue Stimulation Sites and the Cochlea SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE acoustic impedance; air conduction; bone conduction; bone vibrator; cochlea; soft tissue conduction ID BONE-CONDUCTION; EAR AB Objectives: Auditory sensation can be elicited by applying a bone conduction vibrator to skin sites on the head, neck, and thorax over soft tissues. This is called soft tissue conduction (STC). We hypothesized that introducing substances with acoustic impedances that sharply deviate from those of soft tissues, such as air pockets, into the soft tissues beneath soft tissue stimulation sites would have an effect on the auditory threshold to stimulation at skin sites over soft tissue. Methods: In human subjects, we assessed the auditory threshold with a bone vibrator applied to several STC sites, especially the cheek, and to several bone conduction sites on the skull. The subjects were equipped with bilateral earplugs. The subject then filled his or her cheek with either air or water, and the auditory threshold was again determined. We also recorded the auditory brain stem response to STC stimulation under the chin in fat sand rats in the absence and presence of subcutaneous air or saline solution pockets (0.4 mL) under the chin. Results: In humans, the threshold to stimulation on the cheek was elevated (13 to 18 dB) in the presence of an air-inflated cheek, but not with a water-filled cheek. In animals, in the presence of an air pocket, the auditory brain stem response threshold was elevated by 10 to 20 dB; no threshold change occurred with a saline solution pocket. Conclusions: The introduction of air (but not water) into the soft tissues beneath the soft tissue stimulation sites led to a threshold elevation in both humans and animals. This was not the case when an identical volume of water was introduced, which would also have interrupted a possible parallel bone conduction pathway. These results provide evidence that soft tissue stimulation at low intensities induces tissue vibrations that are transmitted to the cochlea along a series of soft tissues with similar acoustic impedances. C1 [Adelman, Cahtia] Hadassah Univ Hosp, Speech & Hearing Ctr, IL-91120 Jerusalem, Israel. [Adelman, Cahtia] Hadassah Acad Coll, Dept Commun Disorders, Jerusalem, Israel. [Perez, Ronen] Shaare Zedek Med Ctr, Dept Otolaryngol Head & Neck Surg, Jerusalem, Israel. [Sohmer, Haim] Hebrew Univ Jerusalem, Hadassah Med Sch, Dept Med Neurobiol Physiol, Inst Med Res Israel Canada, IL-91120 Jerusalem, Israel. RP Sohmer, H (reprint author), Hebrew Univ Jerusalem, Hadassah Med Sch, Dept Med Neurobiol Physiol, IL-91120 Jerusalem, Israel. CR Adelman C, 2011, EUR ARCH OTO-RHINO-L, V269, P425 Chordekar S, 2012, HEARING RES, V283, P180, DOI 10.1016/j.heares.2011.10.004 Dean M S, 2000, Am J Audiol, V9, P131, DOI 10.1044/1059-0889(2000/011) de Jong MA, 2012, ANN OTO RHINOL LARYN, V121, P625 HYVARINE.J, 1968, SCIENCE, V162, P1130, DOI 10.1126/science.162.3858.1130 Ito T, 2011, AUDIOL NEURO-OTOL, V16, P12, DOI 10.1159/000314282 Kaufmann M., 2012, AUDIOL NEUROOTOL EXT, V2, P9 Kim N, 2011, JARO-J ASSOC RES OTO, V12, P261, DOI 10.1007/s10162-011-0258-3 MELZER P, 1984, HEARING RES, V15, P187, DOI 10.1016/0378-5955(84)90050-9 Ozer Eyal, 2002, Journal of Basic and Clinical Physiology and Pharmacology, V13, P89 Perez R, 2011, HEARING RES, V280, P82, DOI 10.1016/j.heares.2011.04.007 Sichel JY, 1999, J OTOLARYNGOL, V28, P217 Sohmer H, 2000, HEARING RES, V146, P81, DOI 10.1016/S0378-5955(00)00099-X Stenfelt S, 2005, OTOL NEUROTOL, V26, P1245, DOI 10.1097/01.mao.0000187236.10842.d5 Tsai V, 2005, OTOL NEUROTOL, V26, P1138, DOI 10.1097/01.mao.0000179996.82402.e0 Vento B. A., 2009, HDB CLIN AUDIOLOGY Watanabe T, 2008, EAR HEARING, V29, P667, DOI 10.1097/AUD.0b013e3181775dde Wever EG, 1954, PHYSL ACOUSTICS NR 18 TC 2 Z9 3 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD AUG PY 2013 VL 122 IS 8 BP 524 EP 528 PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA 202CV UT WOS:000323192000008 PM 24027863 ER PT J AU Albu, S Amadori, M Babighian, G AF Albu, Silviu Amadori, Maurizio Babighian, Gregorio TI Predictors of Hearing Preservation in the Management of Labyrinthine Fistulas Positioned on the Semicircular Canals SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE cholesteatoma surgery; hearing outcome; labyrinthine fistula; prognostic factor; semicircular canal ID SURGICAL-TREATMENT; CHOLESTEATOMA SURGERY; OTITIS-MEDIA; OCCLUSION; EAR AB Objectives: We sought to identify factors that would predict hearing preservation in the treatment of semicircular canal labyrinthine fistulas. Methods: Between 1990 and 2010,97 patients with semicircular canal fistulas were operated on and enrolled in this retrospective study. In 62 patients the matrix was removed and the fistula was sealed, whereas in 35 patients the canal was drilled, the matrix was detached, and the canal was occluded. Perioperative corticosteroids were administered in 51 patients. The main outcome measures were the bone conduction thresholds evaluated at 1 year after the operation. Factors considered for possible association with hearing preservation included age, gender, site and size of the fistula, primary versus revision surgery, surgeon, perioperative corticosteroid treatment, and surgical management of the fistula. Results: The bone conduction hearing level was improved in 16 patients, remained unchanged in 73 patients, and had worsened in 11 patients. On the univariate analysis, good hearing was predicted by grade II fistula, canal plugging, and corticosteroid treatment. However, none of these factors attained significance in the logistic regression model. Conclusions: In surgery of semicircular canal fistulas, good hearing outcomes are to be expected if perioperative corticosteroids are administered, matrix removal and fistula sealing is performed in grade H fistulas, and canal occlusion is performed in grade III and IV fistulas. C1 [Albu, Silviu; Amadori, Maurizio; Babighian, Gregorio] Osped Civile Venezia, Dept Otolaryngol, Venice, Italy. [Babighian, Gregorio] Univ Hosp, Dept Otosurg, Padua, Babighian, Italy. RP Albu, S (reprint author), Univ Med & Pharm Cluj Napoca, Dept Otolaryngol 2, Str Republ 18, Cluj Napoca 400015, Romania. CR Chen ZN, 2010, ACTA OTO-LARYNGOL, V130, P75, DOI 10.3109/00016480902875083 Committee on Hearing and Equilibrium. Committee on Hearing and Equilibrium guidelines for the evaluation of results of treatment of conductive hearing loss. American Academy of OtolaryngologyY Head and Neck Surgery Foundation Inc, 1995, OTOLARYNGOL HEAD NEC, V113, P186 Copeland BJ, 2003, AM J OTOLARYNG, V24, P51, DOI 10.1053/ajot.2003.10 DORNHOFFER JL, 1995, OTOLARYNG HEAD NECK, V112, P410, DOI 10.1016/S0194-5998(95)70275-X FREEMAN P, 1978, CLIN OTOLARYNGOL, V3, P315, DOI 10.1111/j.1365-2273.1978.tb00706.x Gacek RR, 1974, ANN OTOL RHINOL S10, V83, P3 Gersdorff MCH, 2000, AM J OTOL, V21, P32, DOI 10.1016/S0196-0709(00)80109-X Gocea A, 2012, EUR ARCH OTO-RHINO-L, V269, P1085, DOI 10.1007/s00405-011-1757-x KOBAYASHI T, 1995, ARCH OTOLARYNGOL, V121, P469 KOBAYASHI T, 1991, ARCH OTOLARYNGOL, V117, P1292 Magliulo G, 1997, AM J OTOL, V18, P697 PALVA T, 1989, ARCH OTOLARYNGOL, V115, P804 PARNES LS, 1991, OTOLARYNG HEAD NECK, V104, P52 Quaranta N, 2009, OTOLARYNG HEAD NECK, V140, P406, DOI 10.1016/j.otohns.2008.11.028 RITTER FN, 1970, LARYNGOSCOPE, V80, P1025, DOI 10.1288/00005537-197007000-00001 SANNA M, 1988, AM J OTOL, V9, P470 SHEEHY JL, 1979, LARYNGOSCOPE, V89, P78 Tabuchi K, 2006, LARYNGOSCOPE, V116, P627, DOI 10.1097/01.mlg.0000200963.69342.d7 Ueda Y, 2009, J LARYNGOL OTOL, V123, P64, DOI 10.1017/S0022215109005118 Yin S, 2008, ACTA OTO-LARYNGOL, V128, P739, DOI 10.1080/00016480701730000 NR 20 TC 0 Z9 0 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD AUG PY 2013 VL 122 IS 8 BP 529 EP 534 PG 6 WC Otorhinolaryngology SC Otorhinolaryngology GA 202CV UT WOS:000323192000009 PM 24027864 ER PT J AU Celenk, F Durucu, C Baysal, E Karatas, ZA Polat, M Bakir, K Mumbuc, S Kanlikama, M AF Celenk, Fatih Durucu, Cengiz Baysal, Elif Karatas, Zeynel A. Polat, Mustafa Bakir, Kemal Mumbuc, Semih Kanlikama, Muzaffer TI Management of Upper Aerodigestive Tract Amyloidosis SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE amyloidosis; larynx; tonsil; upper aerodigestive tract ID LOCALIZED LARYNGEAL AMYLOIDOSIS; EXPERIENCE; HEAD; NECK AB Objectives: The aim of this study was to discuss the treatment options for upper aerodigestive tract amyloidosis. Methods: Four patients with histologically confirmed amyloidosis were included in the study. All patients underwent surgical treatment. Three patients had laryngeal amyloidosis, and 1 patient had tonsillar amyloidosis. Results: Two of the cases of laryngeal amyloidosis were successfully treated with a combination of surgery and radiation therapy. One case of laryngeal amyloidosis was treated with surgery alone. The tonsillar amyloidosis was removed by tonsillectomy. None of the cases showed systemic involvement. Long-term follow-up of the patients showed no recurrence or evidence of systemic disease. Conclusions: Surgical resection is the primary treatment for patients with upper aerodigestive tract amyloidosis. Radiation therapy is especially effective in cases of recurrent amyloidosis with submucosal involvement. Pedunculated polypoid lesions may be treated with surgery alone, and in cases of recurrence, irradiation following the surgical removal should be considered. Tonsillectomy is usually sufficient for treating tonsillar amyloidosis. C1 [Celenk, Fatih; Durucu, Cengiz; Baysal, Elif; Karatas, Zeynel A.; Polat, Mustafa; Mumbuc, Semih; Kanlikama, Muzaffer] Gaziantep Univ, Fac Med, Dept Otorhinolaryngol, Gaziantep, Turkey. [Bakir, Kemal] Gaziantep Univ, Fac Med, Dept Pathol, Gaziantep, Turkey. RP Celenk, F (reprint author), Gaziantep Univ, Fac Med, Dept Otorhinolaryngol, Gaziantep, Turkey. CR Alaani A, 2004, J LARYNGOL OTOL, V118, P279 Ben Salah R, 2012, EUR ARCH OTO-RHINO-L, V269, P1301, DOI 10.1007/s00405-011-1886-2 Ergas D, 2006, ISRAEL MED ASSOC J, V8, P73 ERIKSEN H E, 1970, Journal of Laryngology and Otology, V84, P525, DOI 10.1017/S0022215100072182 Gallivan GJ, 2010, J VOICE, V24, P235, DOI 10.1016/j.jvoice.2008.07.006 HELLQUIST H, 1979, ACTA OTO-LARYNGOL, V88, P443, DOI 10.3109/00016487909137191 Kennedy TL, 2000, LARYNGOSCOPE, V110, P918 KERNER MM, 1995, ARCH OTOLARYNGOL, V121, P778 Ma LL, 2005, ARCH PATHOL LAB MED, V129, P215 Neben-Wittich MA, 2007, CHEST, V132, P262, DOI 10.1378/chest.06-3118 Neuner GA, 2012, HEAD NECK-J SCI SPEC, V34, P748, DOI 10.1002/hed.21626 Passerotti Gustavo Haruo, 2008, Braz J Otorhinolaryngol, V74, P462 Penner CR, 2006, ORAL ONCOL, V42, P421, DOI 10.1016/j.oraloncology.2005.09.010 Pribitkin E, 2003, LARYNGOSCOPE, V113, P2095, DOI 10.1097/00005537-200312000-00007 RAYMOND AK, 1992, ANN OTO RHINOL LARYN, V101, P794 Saleem Taimur, 2009, JPMA Journal of the Pakistan Medical Association, V59, P789 Thompson LDR, 2000, MODERN PATHOL, V13, P528, DOI 10.1038/modpathol.3880092 Truong MT, 2012, INT J RADIAT ONCOL, V83, P734, DOI 10.1016/j.ijrobp.2011.07.036 Wierzbicka M, 2012, AMYLOID, V19, P177, DOI 10.3109/13506129.2012.723073 NR 19 TC 0 Z9 0 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD AUG PY 2013 VL 122 IS 8 BP 535 EP 540 PG 6 WC Otorhinolaryngology SC Otorhinolaryngology GA 202CV UT WOS:000323192000010 PM 24027865 ER PT J AU Steiner, JI Fink, AM Berkowitz, RG AF Steiner, Joel I. Fink, A. Michelle Berkowitz, Robert G. TI Magnetic Resonance Imaging Findings in Pediatric Bilateral Vocal Fold Dysfunction SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE congenital vocal fold palsy; magnetic resonance imaging; vocal fold; vocal fold paralysis ID CORD PARALYSIS AB Objectives: We studied the findings of brain magnetic resonance imaging (MRI) in infants with idiopathic congenital bilateral vocal fold dysfunction (CBVFD). Methods: We performed a retrospective investigation of a case series. Results: We identified 26 children (14 male, 12 female) over 11 years. Three children were excluded. Thirteen patients required airway interventions, including continuous positive airway pressure (4 patients), endotracheal intubation (1), and tracheostomy (8). The findings on brain MRI were abnormal in 8 patients (35%). Tracheostomy was required in 3 patients (38%) with abnormal MRI findings, as compared with 5 of 15 patients (33%) with normal MRI findings. The MRI abnormalities involved evidence of white matter injury (2), abnormal white matter signal (1), subdural blood (3), cerebral swelling (1), and perisylvian polymicrogyria (1). The cranial ultrasound findings were abnormal in 4 of 11 patients. The MRI findings were abnormal in 2 of 7 children in whom the cranial ultrasound findings were normal, and in 2 of the 4 patients in whom the cranial ultrasound findings were abnormal. Conclusions: The MRI abnormalities were nonspecific; however, they may indicate unrecognized perinatal intracranial injury as being related to CBVFD. In addition, MM may reveal an underlying structural brain anomaly. Cranial ultrasound has poor sensitivity and specificity. Hence, MRI should be considered as part of the routine assessment of neonates with CBVFD. C1 [Steiner, Joel I.; Berkowitz, Robert G.] Univ Melbourne, Murdoch Childrens Res Inst, Melbourne, Vic 3010, Australia. [Fink, A. Michelle] Univ Melbourne, Dept Radiol, Melbourne, Vic 3010, Australia. [Fink, A. Michelle] Royal Childrens Hosp, Dept Med Imaging, Melbourne, Vic, Australia. [Berkowitz, Robert G.] Royal Childrens Hosp, Dept Otolaryngol, Melbourne, Vic, Australia. [Berkowitz, Robert G.] Macquarie Univ, Australian Sch Adv Med, Sydney, NSW 2109, Australia. RP Steiner, JI (reprint author), Alfred Hosp, POB 315, Prahran, Vic 3181, Australia. RI Fink, Michelle/I-7102-2013 CR Berkowitz RG, 1996, ANN OTO RHINOL LARYN, V105, P207 Berkowitz RG, 2005, ANN OTO RHINOL LARYN, V114, P494 Berkowitz RG, 2003, ANN OTO RHINOL LARYN, V112, P764 Berkowitz RG, 2007, OTOLARYNG HEAD NECK, V136, P649, DOI 10.1016/j.otohns.2006.11.050 Berkowitz RG, 2001, ANN OTO RHINOL LARYN, V110, P624 Holden KR, 1999, J CHILD NEUROL, V14, P708, DOI 10.1177/088307389901401104 HOLINGER LD, 1976, ANN OTO RHINOL LARYN, V85, P428 Lapena Jr JF, 2001, ANN OTO RHINOL LARYN, V110, P952 NR 8 TC 0 Z9 0 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD JUL PY 2013 VL 122 IS 7 BP 417 EP 420 PG 4 WC Otorhinolaryngology SC Otorhinolaryngology GA 184HM UT WOS:000321880700001 PM 23951691 ER PT J AU Lee, J Kim, Y Park, C Jeon, Y Kim, D Joo, J Kang, H AF Lee, Jungah Kim, Yongshin Park, Chansoon Jeon, Yeonsu Kim, Daewoo Joo, Jinduk Kang, Hyerim TI Comparison Between Dexmedetomidine and Remifentanil for Controlled Hypotension and Recovery in Endoscopic Sinus Surgery SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE controlled hypotension; dexmedetomidine; endoscopic sinus surgery; remifentanil ID TOTAL INTRAVENOUS ANESTHESIA; IMPROVE SURGICAL CONDITIONS; SODIUM-NITROPRUSSIDE; BLOOD-LOSS; TYMPANOPLASTY; ISOFLURANE; PROPOFOL; ESMOLOL AB Objectives: We compared the efficacy of dexmedetomidine and remifentanil hydrochloride in intraoperative field conditions and recovery during endoscopic sinus surgery. Methods: Sixty-six patients (American Society of Anesthesiologists physical status I and II) scheduled for elective endoscopic sinus surgery were enrolled in this prospective, double-blinded, randomized study. The patients were randomly assigned to two groups. Propofol, 2 to 2.5 mg/kg, was administered to both groups to induce anesthesia, which was maintained with desflurane. One group received dexmedetomidine 1 mu g/kg over 10 minutes at anesthesia induction, followed by 0.4 to 0.8 mu g/kg per hour infusion during maintenance, whereas the other group received remifentanil 1 mu g/kg over 1 minute at anesthesia induction, followed by 0.2 to 0.4 mu g/kg per minute infusion during maintenance. Surgical conditions, hemodynamic parameters, intraoperative blood loss, time to extubation, sedation, and pain in the postanesthesia care unit (PACU) were recorded. Results: There were no significant differences between the two groups with respect to surgical field conditions, blood loss, or extubation time. The sedation score (Modified Observer's Assessment of Alertness/Sedation) in the PACU was significantly lower in the dexmedetomidine group than in the remifentanil group (p < 0.001). No differences were found in total blood loss, surgical field conditions, hemodynamic parameters, time to extubation, or pain in the PACU when the two groups were compared (p > 0.05). Conclusions: Although remifentanil and dexmedetomidine both enabled hypotensive anesthesia and good intraoperative fields for endoscopic sinus surgery, recovery was faster with remifentanil than with dexmedetomidine in the immediate postoperative period. C1 [Lee, Jungah; Kim, Yongshin; Jeon, Yeonsu; Kim, Daewoo; Joo, Jinduk; Kang, Hyerim] Catholic Univ Korea, Dept Anesthesiol & Pain Med, Suwon, South Korea. [Park, Chansoon] Catholic Univ Korea, Dept Otolaryngol, Suwon, South Korea. RP Kim, Y (reprint author), Catholic Univ Korea, St Vincent Hosp, Dept Anesthesiol & Pain Med, Suwon, South Korea. CR Aantaa R, 1997, ANESTHESIOLOGY, V86, P1055, DOI 10.1097/00000542-199705000-00008 AMARANATH L, 1976, ANESTHESIOLOGY, V44, P345, DOI 10.1097/00000542-197604000-00016 Arain SR, 2002, ANESTH ANALG, V95, P461, DOI 10.1213/01.ANE.0000019085.69108.A3 Ayoglu H, 2008, J CLIN ANESTH, V20, P437, DOI 10.1016/j.jclinane.2008.04.008 Bhana N, 2000, DRUGS, V59, P263, DOI 10.2165/00003495-200059020-00012 BOEZAART AP, 1995, CAN J ANAESTH, V42, P373 Bulow NMH, 2007, J CLIN ANESTH, V19, P280, DOI 10.1016/j.jclinane.2007.01.004 Cincikas Darius, 2003, Medicina (Kaunas), V39, P852 Coursin D B, 2001, Curr Opin Crit Care, V7, P221, DOI 10.1097/00075198-200108000-00002 Dal D, 2004, EUR J ANAESTH, V21, P902, DOI 10.1017/S0265021504000262 Davies MJ, 2002, TRANSFUS APHER SCI, V27, P55, DOI 10.1016/S1473-0502(02)00026-5 Degoute CS, 2003, CAN J ANAESTH, V50, P270 Degoute CS, 2001, CAN J ANAESTH, V48, P20 Durmus M, 2007, EUR J ANAESTH, V24, P447, DOI 10.1017/S0265021506002122 Eberhart LHJ, 2003, LARYNGOSCOPE, V113, P1369, DOI 10.1097/00005537-200308000-00019 HAYASHI Y, 1993, BRIT J ANAESTH, V71, P108, DOI 10.1093/bja/71.1.108 Hogue CW, 1996, ANESTH ANALG, V83, P279, DOI 10.1097/00000539-199608000-00014 Jacobi KE, 2000, J CLIN ANESTH, V12, P202, DOI 10.1016/S0952-8180(00)00145-8 Lawrence CJ, 1996, ANESTH ANALG, V83, P1160, DOI 10.1097/00000539-199612000-00005 LINDOP MJ, 1975, BRIT J ANAESTH, V47, P799 Manola M, 2005, ORL J OTO-RHINO-LARY, V67, P83, DOI 10.1159/000084576 Ryu JH, 2009, BRIT J ANAESTH, V103, P490, DOI 10.1093/bja/aep229 Shander A, 2004, CRIT CARE MED, V32, P1094 Shander A, 2003, CRIT CARE MED S, V31, P708 Tobias JD, 2002, PAEDIATR ANAESTH, V12, P171, DOI 10.1046/j.1460-9592.2002.00805.x NR 25 TC 0 Z9 0 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD JUL PY 2013 VL 122 IS 7 BP 421 EP 426 PG 6 WC Otorhinolaryngology SC Otorhinolaryngology GA 184HM UT WOS:000321880700002 PM 23951692 ER PT J AU Miyake, N Kawamoto, K Fujiwara, K Hasegawa, Y Kitano, H AF Miyake, Naritomo Kawamoto, Katsuyuki Fujiwara, Kazunori Hasegawa, Yuji Kitano, Hiroya TI Subglottic Laryngeal Closure: A Unique Modified Method of Laryngotracheal Separation to Prevent Aspiration SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE aspiration pneumonia; fistula; laryngotracheal separation; local anesthesia; total laryngectomy; tracheostomy ID INTRACTABLE ASPIRATION; TRACHEOESOPHAGEAL DIVERSION; PHARYNGOCUTANEOUS FISTULA; SURGERY; COMPLICATION; PNEUMONIA; HEAD AB Objectives: Laryngotracheal separation (LTS) is an ideal surgical method for intractable aspiration; however, the oral side of the tracheal stump can easily disintegrate. Therefore, we developed a modified LTS method. We performed subglottic laryngeal closure (SGLC) as a new surgical method and evaluated the outcomes. Methods: We retrospectively analyzed the medical records of 36 patients (28 male and 8 female; 15 to 91 years of age) who underwent SGLC between 2007 and 2011 at Tottori University Hospital, Japan. Operative data (operative time, intraoperative bleeding, and time to drain removal), outcomes (aspiration and changes in nutritional status), and complications with regard to the surgical method were examined. The occurrence of a subcutaneous proximal laryngeal stump fistula was evaluated by videofluoroscopy. Results: The SGLC was performed safely in all patients. Fistulization was observed in only 1 of the patients (2.8%), and major bleeding after surgery was observed in 1 patient (2.8%). The procedure relieved aspiration pneumonia in all patients. Conclusions: We conclude that SGLC is effective for treating and preventing pulmonary aspiration. The incidence of postoperative complications, particularly that of subcutaneous fistulas, was very low. Therefore, this method may be useful for patients in poor condition. C1 [Miyake, Naritomo; Kawamoto, Katsuyuki; Fujiwara, Kazunori; Hasegawa, Yuji; Kitano, Hiroya] Tottori Univ, Fac Med, Div Otolaryngol Head & Neck Surg, Dept Sensory & Motor Organs, Yonago, Tottori 6838503, Japan. RP Miyake, N (reprint author), Tottori Univ, Fac Med, Div Otolaryngol Head & Neck Surg, Dept Sensory & Motor Organs, Nishi Machi 86, Yonago, Tottori 6838503, Japan. CR BARON BC, 1980, LARYNGOSCOPE, V90, P1927, DOI 10.1288/00005537-198012000-00002 BARTLETT JG, 1975, CHEST, V68, P560, DOI 10.1378/chest.68.4.560 Cavalot AL, 2000, OTOLARYNG HEAD NECK, V123, P587, DOI 10.1067/mhn.2000.110617 Crary MA, 2005, ARCH PHYS MED REHAB, V86, P1516, DOI 10.1016/j.apmr.2004.11.049 DEDO DD, 1975, ANN OTO RHINOL LARYN, V84, P833 Dirven R, 2009, LARYNGOSCOPE, V119, P1691, DOI 10.1002/lary.20521 EIBLING DE, 1995, LARYNGOSCOPE, V105, P83, DOI 10.1288/00005537-199501000-00018 EISELE DW, 1988, ANN OTO RHINOL LARYN, V97, P471 EISELE DW, 1989, AM J SURG, V157, P230, DOI 10.1016/0002-9610(89)90534-5 Halama A. R., 1994, Acta Oto-Rhino-Laryngologica Belgica, V48, P217 HAWTHORNE M, 1987, J LARYNGOL OTOL, V101, P283, DOI 10.1017/S0022215100101641 Kano M, 2008, KOUTOU, V20, P5 LOGEMANN JA, 1985, ANN OTO RHINOL LARYN, V94, P373 Ogihara H, 2009, AURIS NASUS LARYNX, V36, P457, DOI 10.1016/j.anl.2008.10.005 SNYDERMAN CH, 1988, ANN OTO RHINOL LARYN, V97, P466 Yamana T, 2001, ORL J OTO-RHINO-LARY, V63, P321, DOI 10.1159/000055766 Zocratto OB, 2012, EUR ARCH OTO-RHINO-L, V269, P1973, DOI 10.1007/s00405-011-1858-6 Zocratto OB, 2006, OTOLARYNG HEAD NECK, V135, P571, DOI 10.1016/j.otohns.2006.05.018 NR 18 TC 0 Z9 0 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD JUL PY 2013 VL 122 IS 7 BP 427 EP 434 PG 8 WC Otorhinolaryngology SC Otorhinolaryngology GA 184HM UT WOS:000321880700003 PM 23951693 ER PT J AU Ablanedo-Terrazas, Y la Barrera, CAD Ruiz-Cruz, M Reyes-Teran, G AF Ablanedo-Terrazas, Yuria la Barrera, Claudia Alvarado-de Ruiz-Cruz, Matilde Reyes-Teran, Gustavo TI Oropharyngeal Syphilis Among Patients Infected With Human Immunodeficiency Virus SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE HIV; human immunodeficiency virus; oropharyngeal syphilis ID HIV-INFECTION; ORAL-CAVITY; DISEASE; UPDATE AB Objectives: There has been a reemergence of syphilis among men who have sex with men over the past decade, especially in patients infected with human immunodeficiency virus (HIV). This study was aimed at describing the Oropharyngeal manifestations of secondary syphilis in HIV-infected patients. We also sought to determine the clinical risk factors for the development of oropharyngeal syphilitic lesions in patients with secondary syphilis Methods: We performed an observational, comparative, retrospective study of HIV-infected patients who were admitted to a tertiary referral center in Mexico City and who had syphilis according to the criteria of the US Centers for Disease Control and Prevention. Results: We identified 44 patients with syphilis, 31 of whom had secondary syphilis and 9 of whom had oropharyngeal manifestations. Lesions involving the anterior tonsillar pillar were the most common, observed in 5 patients; and tongue lesions were observed in 3 patients. In the patients with secondary syphilis, multivariate analysis showed that the development of oropharyngeal lesions was not associated with age, CD4 and CD8 cell counts, or HIV RNA viral load. Conclusions: The present work shows that oropharyngeal manifestations of secondary syphilis and overlapping stages of syphilis are frequent in HIV-infected patients. To the best of our knowledge, this is the first comparative study of the oropharyngeal manifestations of syphilis in HIV-infected patients. C1 [Ablanedo-Terrazas, Yuria; la Barrera, Claudia Alvarado-de; Ruiz-Cruz, Matilde; Reyes-Teran, Gustavo] Natl Inst Resp Dis Ismael Cosio Villegas, Infect Dis Res Ctr, Mexico City, DF, Mexico. RP Reyes-Teran, G (reprint author), Inst Nacl Enfermedades, Ctr Invest Enfermedades Infecciosas, Calz Tlalpan 4502,Col Secc 16, Mexico City 14080, DF, Mexico. FU Mexican Government (Comision de Equidad y Genero de la Honorable Camara de Diputados de la LXI Legislatura de Mexico) FX From the Infectious Diseases Research Center, National Institute of Respiratory Diseases Ismael Cosio Villegas, Mexico City, Mexico. This work was supported by grants from the Mexican Government (Comision de Equidad y Genero de la Honorable Camara de Diputados de la LXI Legislatura de Mexico). CR Aquilina Christian, 2003, J Am Acad Dermatol, V49, P749, DOI 10.1067/S0190-9622(03)00484-5 Centers for Disease Control and Prevention, 2007, SEX TRANSM DIS SU S Centers for Disease Control and Prevention, 2010, MMWR-MORBID MORTAL W, V59, P26 Chow EPF, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0022768 Compilato D, 2009, ORAL SURG ORAL MED O, V108, pE45, DOI 10.1016/j.tripleo.2009.05.013 Cruz AR, 2010, PLOS NEGLECT TROP D, V4, DOI 10.1371/journal.pntd.0000690 Ficarra Giuseppe, 2009, Head Neck Pathol, V3, P195, DOI 10.1007/s12105-009-0127-0 Flynn TR, 2010, NEW ENGL J MED, V362, P740, DOI 10.1056/NEJMcpc0910089 French P, 2009, INT J STD AIDS, V20, P300, DOI 10.1258/ijsa.2008.008510 Garcia-Garcia L, 2011, BMJ OPEN, V1, DOI 10.1136/bmjopen-2011-000270 GERBER MA, 1984, J CLIN MICROBIOL, V20, P993 Gugatschka M, 2012, B-ENT, V8, P65 Kleidermacher P, 1998, OTOLARYNG HEAD NECK, V119, P399, DOI 10.1016/S0194-5998(98)70088-9 Lahav G, 2011, ARCH OTOLARYNGOL, V137, P294, DOI 10.1001/archoto.2011.16 Little JW, 2005, ORAL SURG ORAL MED O, V100, P3, DOI 10.1016/j.tripleo.2005.03.006 Little James W, 2006, Oral Surg Oral Med Oral Pathol Oral Radiol Endod, V101, P137, DOI 10.1016/j.tripleo.2005.05.077 Miller BA, SYPHILIS HIV INTERSE Pialoux G, 2008, AIDS REV, V10, P85 Pletcher SD, 2003, OTOLARYNG CLIN N AM, V36, P595, DOI 10.1016/S0030-665(03)00025-2 Thumheer MC, 2010, AIDS, V24, P1907, DOI [10.1097/QAD.0b013e32833bfe21, DOI 10.1097/QAD.0B013E32833BFE21] Vinals-Iglesias H, 2009, MED ORAL PATOL ORAL, V14, pE416 Wharton M, 1990, MMWR Recomm Rep, V39, P1 Yang CJ, 2010, CLIN INFECT DIS, V51, P976, DOI 10.1086/656419 Zetola NM, 2007, CLIN INFECT DIS, V44, P1222, DOI 10.1086/513427 NR 24 TC 0 Z9 0 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD JUL PY 2013 VL 122 IS 7 BP 435 EP 439 PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA 184HM UT WOS:000321880700004 PM 23951694 ER PT J AU Eckley, CA Sardinha, LR Rizzo, LV AF Eckley, Claudia A. Sardinha, Luis Roberto Rizzo, Luiz Vicente TI Salivary Concentration of Epidermal Growth Factor in Adults With Reflux Laryngitis Before and After Treatment SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE epidermal growth factor; gastroesophageal reflux disease; GERD; larynx; saliva ID EVIDENCE-BASED CONSENSUS; GASTROESOPHAGEAL-REFLUX; LARYNGOPHARYNGEAL REFLUX; ESOPHAGEAL MUCOSA; DISEASE; MANIFESTATIONS; PREVALENCE; RELIABILITY; POPULATION; DEFINITION AB Objectives: The diagnosis of laryngopharyngeal reflux (LPR) is controversial. There is no correlation between the number of reflux episodes and the severity of the inflammatory response at the esophagus or the laryngopharyngeal segment. Some authors have suggested that decreased salivary epidermal growth factor (EGF) concentrations in patients with gastroesophageal reflux disease and LPR point to a breakdown in the local defenses. Our objective was to establish whether treatment of the disease influences low salivary EGF concentrations. Methods: The spontaneous whole saliva of 20 adults with LPR was sampled at a tertiary teaching hospital before and after a 16-week course of full-dose proton pump inhibitor and compared to that of 12 healthy controls. Salivary EGF concentrations were established with a commercially available enzyme-linked immunosorbent assay kit. Results: Although the mean salivary EGF concentrations were higher before treatment than after treatment and control of the disease (25,083 versus 19,359 pg/mL), this difference was not statistically significant (p = 0.065). The mean salivary EGF concentration of healthy control subjects was significantly higher (54,509 pg/mL; p < 0.0001). Conclusions: Both before and after treatment, patients with reflux laryngitis present lower salivary EGF concentrations than healthy control subjects, suggesting a primary deficit in their protective mechanisms. C1 Santa Casa Sch Med, Dept Otolaryngol, Sao Paulo, Brazil. Hosp Sao Paulo, Sao Paulo, Brazil. RP Eckley, CA (reprint author), Av Vereador Jose Diniz 3457,Cj 501, Sao Paulo, Brazil. CR Ali MES, 2008, CURR OPIN ALLERGY CL, V8, P28, DOI 10.1097/ACI.0b013e3282f3f44f Barry DW, 2010, CLEV CLIN J MED, V77, P327, DOI 10.3949/ccjm.77a.09121 Belafsky PC, 2002, J VOICE, V16, P274, DOI 10.1016/S0892-1997(02)00097-8 Belafsky PC, 2001, LARYNGOSCOPE, V111, P1313, DOI 10.1097/00005537-200108000-00001 Dore MP, 2007, DIGEST DIS SCI, V52, P463, DOI 10.1007/s10620-006-9573-7 Eckley CA, 2004, OTOLARYNG HEAD NECK, V131, P401, DOI 10.1016/j.otohns.2004.01.020 Eckley CA, 2007, BRAZ J OTORHINOLAR, V73, P156 Fass R, 2004, DIGEST DIS, V22, P100, DOI 10.1159/000080307 Groome M, 2007, LARYNGOSCOPE, V117, P1424, DOI 10.1097/MLG.0b013e31806865cf Gupta R, 2009, CURR OPIN OTOLARYNGO, V17, P143, DOI 10.1097/MOO.0b013e32832b2581 HELM JF, 1987, GASTROENTEROLOGY, V93, P1393 ITOH M, 1988, J CLIN GASTROENTEROL, V10, pS7, DOI 10.1097/00004836-198812001-00003 JANKOWSKI J, 1993, DIGEST DIS, V11, P1, DOI 10.1159/000171396 Jaspersen D, 2003, ALIMENT PHARM THERAP, V17, P1515, DOI 10.1046/j.0269-2813.2003.01606.x Johnston N, 2004, LARYNGOSCOPE, V114, P2129, DOI 10.1097/01.mlg.0000149445.07146.03 Khan AM, 2006, SURG-J R COLL SURG E, V4, P221 Koufman JA, 2002, OTOLARYNGOL HEAD NEC, V127, P32 Mahieu HF, 2007, ALIMENT PHARM THERAP, V26, P17, DOI 10.1111/j.1365-2036.2007.03474.x Marcinkiewicz M, 2000, AM J GASTROENTEROL, V95, P1652 Navarro-Rodriguez Tomás, 2007, Curr Treat Options Gastroenterol, V10, P294, DOI 10.1007/s11938-007-0072-5 Noordzij JP, 2001, LARYNGOSCOPE, V111, P2147, DOI 10.1097/00005537-200112000-00013 OLSEN PS, 1984, GASTROENTEROLOGY, V87, P103 Postma Gregory N, 2002, Ear Nose Throat J, V81, P14 Qua CS, 2007, ALIMENT PHARM THERAP, V25, P287, DOI 10.1111/j.1365-2036.2006.03185.x Richter JE, 2005, ALIMENT PHARM THERAP, V22, P70, DOI 10.1111/j.1365-2036.2005.02613.x ROURK RM, 1994, AM J GASTROENTEROL, V89, P237 SAROSIEK J, 1995, DIGESTION, V56, P32 Sato K, 2009, J LARYNGOL OTOL, V123, P42, DOI 10.1017/S0022215109005076 Sherman PM, 2009, AM J GASTROENTEROL, V104, P1278, DOI 10.1038/ajg.2009.129 SONNENBERG A, 1982, GASTROENTEROLOGY, V83, P889 Vaezi Michael F, 2008, Curr Gastroenterol Rep, V10, P271, DOI 10.1007/s11894-008-0055-2 Vakil N, 2006, AM J GASTROENTEROL, V101, P1900, DOI 10.1111/j.1572-0241.2006.00630.x NR 32 TC 0 Z9 0 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD JUL PY 2013 VL 122 IS 7 BP 440 EP 444 PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA 184HM UT WOS:000321880700005 PM 23951695 ER PT J AU Setlur, J Maturo, S Hartnick, CJ AF Setlur, Jennifer Maturo, Stephen Hartnick, Christopher J. TI Novel Method for Laryngotracheal Reconstruction: Combining Single- and Double-Stage Techniques SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE airway surgery; laryngotracheal reconstruction; pediatrics; subglottic stenosis; tracheostomy ID SUBGLOTTIC STENOSIS; MANAGEMENT; CHILDREN; INFANTS AB Objectives: Traditional open techniques for laryngotracheal reconstruction are either single- or double-stage procedures. Some patients may benefit from the presence of a long, single-tube stent, such as an endotracheal tube, but their predicted need for a 2-stage procedure and a persistent tracheostomy is high. We describe a novel technique for airway reconstruction that combines the methods of both single- and double-stage procedures. Methods: We present a retrospective review of 4 patients. All patients underwent laryngotracheal reconstruction by a single surgeon. After the operation, the airway was stented with nasotracheal intubation. A small stent, fashioned from an endotracheal tube, was placed in the tracheostoma to keep it patent. The patients subsequently underwent extubation and replacement of the tracheostomy tube. Results: The study included 1 patient with grade 4 subglottic stenosis, 2 patients with grade 3 subglottic stenosis, and 1 patient with a posterior glottic scar. All were tracheostomy tube dependent. Serial bronchoscopy was used to follow the patients for a minimum of 9 months after the operation. All 4 patients have since met the criteria for decannulation. Conclusions: This hybrid reconstruction merges the advantages of both the single- and double-stage procedures. It adds versatility to the surgical toolbox for airway reconstruction. C1 [Setlur, Jennifer; Maturo, Stephen; Hartnick, Christopher J.] Massachusetts Eye & Ear Infirm, Dept Otolaryngol, Boston, MA 02114 USA. [Setlur, Jennifer; Hartnick, Christopher J.] Harvard Univ, Sch Med, Dept Otol & Laryngol, Boston, MA 02115 USA. RP Hartnick, CJ (reprint author), Massachusetts Eye & Ear Infirm, Dept Otolaryngol, 243 Charles St, Boston, MA 02114 USA. CR Agrawal N, 2007, INT J PEDIATR OTORHI, V71, P699, DOI 10.1016/j.ijporl.2007.01.005 Bauman NM, 1996, ANN OTO RHINOL LARYN, V105, P317 Choi SS, 1999, ARCH OTOLARYNGOL, V125, P650 FEARON B, 1974, ANN OTO RHINOL LARYN, V83, P428 Gustafson LM, 2000, OTOLARYNG HEAD NECK, V123, P430, DOI 10.1067/mhn.2000.109007 Herrington HC, 2006, LARYNGOSCOPE, V116, P1553, DOI 10.1097/01.mlg.0000228006.21941.12 Jacobs BR, 2001, CRIT CARE MED, V29, P164, DOI 10.1097/00003246-200101000-00032 Liew LBS, 2003, INT C SER, V1254, P147, DOI 10.1016/S0531-5131(03)01103-8 LUSK RP, 1991, ARCH OTOLARYNGOL, V117, P171 MYER CM, 1994, ANN OTO RHINOL LARYN, V103, P319 Myer CM, 2000, LARYNGOSCOPE, V110, P1875, DOI 10.1097/00005537-200011000-00021 PRESCOTT CAJ, 1988, ANN OTO RHINOL LARYN, V97, P239 ROTHSCHILD MA, 1995, ARCH OTOLARYNGOL, V121, P1175 Santos D, 2010, LARYNGOSCOPE, V120, P815, DOI 10.1002/lary.20823 Saunders MW, 1999, INT J PEDIATR OTORHI, V50, P51, DOI 10.1016/S0165-5876(99)00235-9 Schmidt RJ, 2011, INT J PEDIATR OTORHI, V75, P1585, DOI 10.1016/j.ijporl.2011.09.012 Smith LP, 2010, ARCH OTOLARYNGOL, V136, P60, DOI 10.1001/archoto.2009.201 WILLIS R, 1987, LARYNGOSCOPE, V97, P764 ZALZAL GH, 1992, ANN OTO RHINOL LARYN, V101, P651 NR 19 TC 5 Z9 6 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD JUL PY 2013 VL 122 IS 7 BP 445 EP 449 PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA 184HM UT WOS:000321880700006 PM 23951696 ER PT J AU Noureldine, SI Khan, A Massasati, SA Kethman, W Kandil, E AF Noureldine, Salem I. Khan, Amna Massasati, Saleh A. Kethman, William Kandil, Emad TI Thyroid Hormone Replacement Therapy, Surveillance Ultrasonography, and Fine-Needle Aspiration After Hemithyroidectomy SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE fine-needle aspiration; hemithyroidectomy; surveillance after hemithyroidectomy; thyroid hormone replacement therapy ID HYPOTHYROIDISM FOLLOWING HEMITHYROIDECTOMY; THYROXINE THERAPY; RISK-FACTORS; FOLLOW-UP; DISEASE; MANAGEMENT; LOBECTOMY; SURGERY; GOITER; CANCER AB Objectives: We undertook a retrospective analysis of a single surgeon's experience at a tertiary care teaching hospital to determine the rates of surveillance ultrasound, fine-needle aspiration (FNA), and the need for thyroid hormone replacement therapy (THRT) after hemithyroidectomy. Methods: The study population comprised 120 consecutive patients who underwent hemithyroidectomy by one surgeon from January 2008 to June 2011. The medical records were reviewed for preoperative and postoperative calcium levels, fiberoptic direct laryngoscopy examination of vocal fold mobility, postoperative complications, final pathology, and postoperative follow-up. Results: Fifteen patients required completion thyroidectomy for malignancy and were excluded from the surveillance analysis. Of the remaining 105 patients, 10 (9.5%) required postoperative THRT. The likelihood for THRT was significantly associated with increased age (p = 0.01) and the presence of thyroiditis (p = 0.04). Other factors, such as gender, body mass index, residual thyroid volume, and presence of contralateral lobe nodules, were not significantly associated with this likelihood (p > 0.05). Twenty-three patients (21.9%) were followed with surveillance ultrasound, of whom 12 (11.4%) underwent FNA for nodule(s) in the contralateral lobe. Seventy-eight percent of patients did not require any long-term postoperative surveillance. There were no instances of permanent recurrent laryngeal nerve injury or hypoparathyroidism. Conclusions: Hemithyroidectomy is an effective and efficient option for the management of benign and suspicious thyroid nodules. However, patients of increased age and/or with thyroiditis are at higher risk for postoperative hypothyroidism, and should be counseled to consider total thyroidectomy to avoid the need for long-term surveillance and the possible need for a second operation. C1 [Noureldine, Salem I.; Massasati, Saleh A.; Kethman, William; Kandil, Emad] Tulane Univ, Sch Med, Dept Surg, Div Endocrine & Oncol Surg, New Orleans, LA 70112 USA. [Khan, Amna] Tulane Univ, Sch Med, Dept Med, Sect Endocrinol Diabet & Metab, New Orleans, LA 70112 USA. RP Kandil, E (reprint author), Tulane Univ, Sch Med, Dept Surg, Endocrine Surg Sect, 1430 Tulane Ave, New Orleans, LA 70112 USA. CR Bahn RS, 2011, ENDOCR PRACT, V17, P456 Bellantone R, 2002, WORLD J SURG, V26, P1468, DOI 10.1007/s00268-002-6426-1 Bennedbaek FN, 1999, CLIN ENDOCRINOL, V50, P357, DOI 10.1046/j.1365-2265.1999.00663.x Bennedbaek FN, 2000, J CLIN ENDOCR METAB, V85, P2493, DOI 10.1210/jc.85.7.2493 BERGLUND J, 1990, ACTA CHIR SCAND, V156, P433 Buchanan MA, 2001, J ROY COLL SURG EDIN, V46, P86 Burman ML, 2004, J STUD ALCOHOL, V65, P621 Carmeci C, 1998, THYROID, V8, P283, DOI 10.1089/thy.1998.8.283 Cooper DS, 2009, THYROID, V19, P1167, DOI 10.1089/thy.2009.0110 De Carlucci Dorival Jr, 2008, Arch Otolaryngol Head Neck Surg, V134, P1076, DOI 10.1001/archotol.134.10.1076 Farkas EA, 2002, AM SURGEON, V68, P678 Fewins J, 2003, OTOLARYNG CLIN N AM, V36, P189, DOI 10.1016/S0030-6665(02)00129-9 Flynn RW, 2010, J CLIN ENDOCR METAB, V95, P186, DOI 10.1210/jc.2009-1625 Friguglietti CUM, 2003, LARYNGOSCOPE, V113, P1820, DOI 10.1097/00005537-200310000-00030 HARVEY HK, 1990, OTOLARYNG CLIN N AM, V23, P303 HEDMAN I, 1986, ACTA CHIR SCAND, V152, P481 Ho Thomas W T, 2011, Am J Surg, V201, P570, DOI 10.1016/j.amjsurg.2010.12.006 Koh YW, 2008, EUR ARCH OTO-RHINO-L, V265, P453, DOI 10.1007/s00405-007-0513-8 Kupferman ME, 2002, LARYNGOSCOPE, V112, P1209, DOI 10.1097/00005537-200207000-00013 Lubitz CC, 2010, THYROID, V20, P25, DOI 10.1089/thy.2009.0208 Mccoy KL, 2008, SURGERY, V143, P302 McHenry CR, 2000, SURGERY, V128, P994, DOI 10.1067/msy.2000.110242 Miller FR, 2006, ARCH OTOLARYNGOL, V132, P36, DOI 10.1001/archotol.132.1.36 Moon HG, 2008, WORLD J SURG, V32, P2503, DOI 10.1007/s00268-008-9717-3 Piper HG, 2005, AM J SURG, V189, P587, DOI 10.1016/j.amjsurg.2005.01.038 REEVE TS, 1987, ANN SURG, V206, P782, DOI 10.1097/00000658-198712000-00016 Repplinger D, 2008, J SURG RES, V150, P49, DOI 10.1016/j.jss.2007.09.020 Rosario PW, 2006, THYROID, V16, P707, DOI 10.1089/thy.2006.16.707 Seiberling KA, 2007, ENT-EAR NOSE THROAT, V86, P295 Sosa JA, 2006, J SURG ONCOL, V94, P701, DOI 10.1002/jso.20695 Spanheimer PM, 2011, ANN SURG ONCOL, V18, P1729, DOI 10.1245/s10434-010-1544-8 Stoll SJ, 2009, SURGERY, V146, P554, DOI 10.1016/j.surg.2009.06.026 Su SY, 2009, ANN SURG, V250, P991, DOI 10.1097/SLA.0b013e3181ae5426 Tomoda C, 2011, ORL-J OTO-RHIN-LARYN, V73, P68, DOI 10.1159/000323007 Vaiman M, 2008, OTOLARYNG HEAD NECK, V138, P98, DOI 10.1016/j.otohns.2007.09.015 Wiersinga WM, 2001, HORM RES, V56, P74, DOI 10.1159/000048140 Wormald R, 2008, CLIN OTOLARYNGOL, V33, P587, DOI 10.1111/j.1749-4486.2008.01794.x Ylagan LR, 2004, THYROID, V14, P35, DOI 10.1089/105072504322783821 NR 38 TC 0 Z9 1 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD JUL PY 2013 VL 122 IS 7 BP 450 EP 456 PG 7 WC Otorhinolaryngology SC Otorhinolaryngology GA 184HM UT WOS:000321880700007 PM 23951697 ER PT J AU Honings, J Dammeijer, PFM AF Honings, Jimmie Dammeijer, Patrick F. M. TI Chronic Otorrhea Caused by Myospherulosis in the Middle Ear After Tympanoplasty SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE antibiotic ointment; lipogranuloma; middle ear; myospherulosis; otorrhea; spherulocystic disease; spherulosis ID DISEASE AB Objectives: Myospherulosis is a foreign body reaction induced by the application of oil-based ointments. Myospherulosis in the ear is extremely rare. Only 4 cases have been described, all of which occurred after (repeated) mastoid surgery. Methods: We present a case of persistent otorrhea and conductive hearing loss caused by myospherulosis in the middle ear following tympanoplasty. Results: The patient underwent revision middle ear surgery with removal of abnormally thick, pale tissue in the middle ear. Histology showed a foreign body reaction with signs of myospherulosis. Conclusions: Myospherulosis is a very rare complication of the use of oil-based ointments. Surgeons should be aware that these products might cause a foreign body reaction leading to myospherulosis. In patients who have chronic otorrhea after previous mastoid or middle ear surgery, myospherulosis should be considered in the differential diagnosis. C1 [Honings, Jimmie] Radboud Univ Nijmegen, Med Ctr, Dept Otorhinolaryngol Head & Neck Surg, NL-6500 HB Nijmegen, Netherlands. RP Honings, J (reprint author), Radboud Univ Nijmegen, Med Ctr, Dept Otorhinolaryngol Head & Neck Surg, POB 9101, NL-6500 HB Nijmegen, Netherlands. CR DESCHRYVERKECSKEMETI K, 1977, AM J PATHOL, V87, P33 GILLESPIE C A, 1990, Auris Nasus Larynx, V16, P199 Hansen T, 2004, LARYNGO RHINO OTOL, V83, P445, DOI 10.1055/s-2004-814448 KYRIAKOS M, 1977, AM J CLIN PATHOL, V67, P118 Lin HW, 2010, AM J OTOLARYNG, V31, P205, DOI 10.1016/j.amjoto.2009.01.002 Mace ATM, 2003, J LARYNGOL OTOL, V117, P496 MANNI JJ, 1992, EUR ARCH OTO-RHINO-L, V249, P231 MCCLATCH.S, 1969, AM J CLIN PATHOL, V51, P699 NR 8 TC 0 Z9 0 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD JUL PY 2013 VL 122 IS 7 BP 461 EP 463 PG 3 WC Otorhinolaryngology SC Otorhinolaryngology GA 184HM UT WOS:000321880700009 PM 23951699 ER PT J AU Celebi, S Tepe, C Yelken, K Celik, O AF Celebi, Saban Tepe, Cigdem Yelken, Kursat Celik, Oner TI Efficacy of Dexpanthenol for Pediatric Post-tonsillectomy Pain and Wound Healing SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE cold dissection tonsillectomy; dexpanthenol; thermal welding tonsillectomy AB Objectives: We evaluated the efficacy of dexpanthenol in managing pediatric post-tonsillectomy pain and wound healing and sought to discover which of two surgical tonsillectomy techniques provides better healing and less postoperative pain. Methods: One hundred twenty patients who underwent tonsillectomy were equally randomized to thermal welding and cold dissection groups. Dexpanthenol pastilles were given to half of each group. Postoperative throat pain was determined with a visual analog scale on the 1st, 3th, 7th, and 14th days, and mucosal healing patterns were assessed on the 7th and 14th days. Results: Regardless of surgical technique, post-tonsillectomy throat pain was significantly less in the dexpanthenol groups than in the placebo groups (p < 0.05), and tonsillar wound healing was significantly better in the dexpanthenol groups than in the placebo groups (p < 0.05). When a comparison was made with regard to surgical technique, wound healing was significantly better in the cold dissection group (p < 0.05), whereas postoperative throat pain was less in the thermal welding group (p < 0.05). Conclusions: Postoperative administration of dexpanthenol significantly accelerates the wound healing process and decreases tonsillectomy-related pain complaints. C1 [Celebi, Saban] Taksim Educ & Res Hosp, Dept Otolaryngol, TR-34421 Istanbul, Turkey. [Tepe, Cigdem] Haydarpasa Numune Educ & Res Hosp, Dept Otolaryngol, Istanbul, Turkey. [Celik, Oner] Maltepe Univ, Fac Med, Dept Otolaryngol, Istanbul, Turkey. [Yelken, Kursat] Gaziomanpasa Univ, Fac Med, Dept Otolaryngol, Tokat, Turkey. RP Celebi, S (reprint author), Taksim Educ & Res Hosp, Dept Otolaryngol, TR-34421 Istanbul, Turkey. CR Ebner Fritz, 2002, Am J Clin Dermatol, V3, P427, DOI 10.2165/00128071-200203060-00005 Elwany S, 2008, J LARYNGOL OTOL, V122, P603, DOI 10.1017/S0022215107009760 FREEMAN SB, 1992, LARYNGOSCOPE, V102, P1242, DOI 10.1288/00005537-199211000-00007 Gulhas N, 2007, ACTA ANAESTH SCAND, V51, P239, DOI 10.1111/j.1399-6576.2006.01180.x Hahn CH, 2009, J LARYNGOL OTOL, V123, P648, DOI 10.1017/S0022215108003654 Parsons SP, 2006, OTOLARYNG HEAD NECK, V134, P106, DOI 10.1016/j.otohns.2005.09.027 Proksch E, 2002, J DERMATOL TREAT, V13, P173 Stavroulaki P, 2007, ANN OTO RHINOL LARYN, V116, P565 NR 8 TC 2 Z9 2 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD JUL PY 2013 VL 122 IS 7 BP 464 EP 467 PG 4 WC Otorhinolaryngology SC Otorhinolaryngology GA 184HM UT WOS:000321880700010 PM 23951700 ER PT J AU Ihler, F Sharaf, K Bertlich, M Strieth, S Reichel, CA Berghaus, A Canis, M AF Ihler, Friedrich Sharaf, Kariem Bertlich, Mattis Strieth, Sebastian Reichel, Christoph A. Berghaus, Alexander Canis, Martin TI Etanercept Prevents Decrease of Cochlear Blood Flow Dose-Dependently Caused by Tumor Necrosis Factor Alpha SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE fluorescence microscopy; guinea pig; stria vascularis; sudden sensorineural hearing loss; TNFR-Fc fusion protein; tumor necrosis factor alpha ID SENSORINEURAL HEARING-LOSS; TNF-ALPHA; ENDOTHELIAL-CELLS; EXPRESSION; DISORDERS; PERICYTES; VEGF; TONE AB Objectives: Tumor necrosis factor alpha (TNF-alpha) is a mediator of inflammation and microcirculation in the cochlea. This study aimed to quantify the effect of a local increase of TNF-alpha and study the effect of its interaction with etanercept on cochlear microcirculation. Methods: Cochlear lateral wall vessels were exposed surgically and assessed by intravital microscopy in guinea pigs in vivo. First, 24 animals were randomly distributed into 4 groups of 6 each. Exposed vessels were superfused repeatedly either with 1 of 3 different concentrations of TNF-alpha (5.0, 0.5, and 0.05 ng/mL) or with placebo (0.9% saline solution). Second, 12 animals were randomly distributed into 2 groups of 6 each. Vessels were pretreated with etanercept (1.0 mu g/mL) or placebo (0.9% saline solution), and then treated by repeated superfusion with TNF-alpha (5.0 ng/mL). Results: TNF-alpha was shown to be effective in decreasing cochlear blood flow at a dose of 5.0 ng/mL (p < 0.01, analysis of variance on ranks). Lower concentrations or placebo treatment did not lead to significant changes. After pretreatment with etanercept, TNF-alpha at a dose of 5.0 ng/mL no longer led to a change in cochlear blood flow. Conclusions: The decreasing effect that TNF-alpha has on cochlear blood flow is dose-dependent. Etanercept abrogates this effect. C1 [Ihler, Friedrich; Sharaf, Kariem; Bertlich, Mattis; Strieth, Sebastian; Reichel, Christoph A.; Canis, Martin] Univ Munich, Walter Brendel Ctr Expt Med, Munich, Germany. [Ihler, Friedrich; Canis, Martin] Univ Munich Hosp, Integrated Ctr Res & Treatment Vertigo Balance &, Munich, Germany. [Reichel, Christoph A.; Berghaus, Alexander] Univ Munich Hosp, Dept Otolaryngol Head & Neck Surg, Munich, Germany. [Ihler, Friedrich; Canis, Martin] Univ Med Ctr Gottingen, Dept Otorhinolaryngol Head & Neck Surg, D-37075 Gottingen, Germany. [Strieth, Sebastian] JW Goethe Univ Hosp, Dept Otolaryngol Head & Neck Surg, Frankfurt, Germany. [Strieth, Sebastian] Fac Med, Frankfurt, Germany. RP Canis, M (reprint author), Univ Med Ctr Gottingen, Dept Otorhinolaryngol Head & Neck Surg, Robert Koch Str 40, D-37075 Gottingen, Germany. FU German Federal Ministry of Education and Research [01 EO 0901]; FoFoLe program of the Faculty of Medicine, University of Munich [S-30] FX From the Walter Brendel Centre of Experimental Medicine, Ludwig-Maximilians-University Munich (Ihler, Sharaf, Bertlich, Strieth, Reichel, Canis), and the Integrated Center for Research and Treatment of Vertigo, Balance and Ocular Motor Disorders (Ihler, Canis) and the Department of Otolaryngology Head and Neck Surgery (Reichel, Berghaus), University of Munich Hospital, Munich, the Department of Otorhinolaryngology Head and Neck Surgery, University Medical Center Gottingen, Gottingen (Ihler, Canis), and the Department of Otolaryngology Head and Neck Surgery, J. W. Goethe University Hospital and Faculty of Medicine, Frankfurt am Main (Strieth), Germany. Authors Ihler and Sharaf contributed equally to this study. This project was supported by funds from the German Federal Ministry of Education and Research to the IFBLMU under the grant code 01 EO 0901. The project was also funded by the FoFoLe program of the Faculty of Medicine, University of Munich, under the grant code S-30 and is part of the doctoral thesis of Mr Sharaf at the University of Munich. This study was performed in accordance with Bavarian, German, and European regulations on the use of laboratory animals. The animal use protocol was approved on December 13, 2010, by the Animal Care and Use Committee of the District Government of Upper Bavaria (Regierung von Oberbayern, Munich, Germany; animal license 55.2-1-54-2531.123-10). CR Armulik A, 2011, DEV CELL, V21, P193, DOI 10.1016/j.devcel.2011.07.001 Axelsson A., 1968, ACTA OTOLARYNGO S243, P3 Baek MJ, 2006, J IMMUNOL, V177, P4203 BAKER M, 1974, MICROVASC RES, V7, P131, DOI 10.1016/0026-2862(74)90043-0 BYL FM, 1984, LARYNGOSCOPE, V94, P647 Canis M, 2010, EUR ARCH OTO-RHINO-L, V267, P197, DOI 10.1007/s00405-009-1036-2 Cindrova-Davies T, 2011, CARDIOVASC RES, V89, P671, DOI 10.1093/cvr/cvq346 Dai M, 2009, HEARING RES, V254, P100, DOI 10.1016/j.heares.2009.04.018 Dai M, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0020652 Giardina JB, 2002, AM J PHYSIOL-REG I, V283, pR130, DOI 10.1152/ajpregu.00704.2001 Kono M, 2007, J BIOL CHEM, V282, P10690, DOI 10.1074/jbc.M700370200 Lobo D, 2006, EUR ARCH OTO-RHINO-L, V263, P622, DOI 10.1007/s00405-006-0027-9 Nakashima T, 2003, BRAIN RES REV, V43, P17, DOI 10.1016/S0165-0173(03)00189-9 Rauch SD, 2008, NEW ENGL J MED, V359, P833, DOI 10.1056/NEJMcp0802129 Satoh H, 2003, JARO, V4, P139, DOI 10.1007/s10162-002-3025-7 Satoh H, 2003, JARO, V4, P291, DOI 10.1007/s10162-002-9001-4 Scherer EQ, 2010, STROKE, V41, P2618, DOI 10.1161/STROKEAHA.110.593327 Scherer EQ, 2006, CARDIOVASC RES, V70, P79, DOI 10.1016/j.cardiores.2006.01.011 Street I, 2006, J LARYNGOL OTOL, V120, P1064, DOI 10.1017/S0022215106002593 Sunderland NS, 2011, CYTOKINE, V56, P192, DOI 10.1016/j.cyto.2011.06.003 Toubi E, 2004, ANN OTO RHINOL LARYN, V113, P445 Wang XB, 2003, OTOL NEUROTOL, V24, P52, DOI 10.1097/00129492-200301000-00012 Xia P, 1999, J BIOL CHEM, V274, P34499, DOI 10.1074/jbc.274.48.34499 ZEINTL H, 1989, INT J MICROCIRC, V8, P293 Zhang HR, 2009, CLIN SCI, V116, P219, DOI 10.1042/CS20080196 Zou J, 2005, HEARING RES, V202, P13, DOI 10.1016/j.heares.2004.10.008 NR 26 TC 3 Z9 3 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD JUL PY 2013 VL 122 IS 7 BP 468 EP 473 PG 6 WC Otorhinolaryngology SC Otorhinolaryngology GA 184HM UT WOS:000321880700011 PM 23951701 ER PT J AU Cingi, C Calli, A Erdogmus, N Calli, C Yilgor, I Yilgor, E Bal, C AF Cingi, Cemal Calli, Aylin Erdogmus, Nagehan Calli, Caglar Yilgor, Iskender Yilgor, Emel Bal, Cengiz TI Two New Polymers as Candidates for Rhinoplasty Allografts: An Experimental Study in a Rabbit Model SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE allograft; biocompatibility; experimental study; nasal reconstruction; polymer; rabbit model; rhinoplasty ID TIP IMPLANTS; REPAIR; RECONSTRUCTION; AUGMENTATION AB Objectives: This study was performed to evaluate the biocompatibility and tensile strength of two new polymeric materials - a polyfluoro ether modified thermoplastic polyurethane urea and a polydimethyl silicone elastomer in an experimental rabbit model. Methods: The two polymers were implanted inside separate subperichondrial pockets created over the auricular cartilages of 12 rabbits. A control pocket received no implant. After 3 months, the animals were painlessly sacrificed, and each site was analyzed histologically for vascular congestion, acute and chronic inflammation, and fibrosis in the tissue surrounding the implant materials. Results: There were no statistically significant differences in vascular congestion, fibrosis, or acute or chronic inflammation between the control sites and either implant site. Conclusions: These results suggest that the polymers are well accepted by the tissue and remain stable during the entire study period, and that they could be very suitable materials for use in nasal reconstruction. C1 [Cingi, Cemal; Erdogmus, Nagehan; Bal, Cengiz] Eskisehir Osmangazi Univ, Dept Otolaryngol, Eskisehir, Turkey. [Calli, Aylin] Ataturk Training & Res Hosp, Dept Pathol, Izmir, Turkey. [Calli, Caglar] Ataturk Training & Res Hosp, Dept Otolaryngol, Izmir, Turkey. [Yilgor, Iskender; Yilgor, Emel] Koc Univ, Dept Chem, Istanbul, Turkey. RP Cingi, C (reprint author), Eskisehir Osmangazi Univ, Dept Otolaryngol, Eskisehir, Turkey. CR Beekhuis GJ, 1986, AM J COSM SURG, V3, P49 Berghaus Alexander, 2006, Curr Opin Otolaryngol Head Neck Surg, V14, P270, DOI 10.1097/01.moo.0000233599.14671.4a Blais P., 1983, BIOMATERIALS RECONST, P112 CALNAN JS, 1970, P ROY SOC MED, V63, P1115 COLTON J J, 1992, Facial Plastic Surgery, V8, P149, DOI 10.1055/s-2008-1064645 COSTANTINO PD, 1994, OTOLARYNG CLIN N AM, V27, P223 FANOUS N, 1991, PLAST RECONSTR SURG, V87, P662, DOI 10.1097/00006534-199104000-00009 FANOUS N, 1987, ARCH OTOLARYNGOL, V113, P728 Gretzer C, 2006, J BIOMAT SCI-POLYM E, V17, P669, DOI 10.1163/156856206777346340 Joseph J, 1987, JOSEPHS RHINOPLASTY, P213 Kridel RWH, 1995, FACIAL PLAST SURG CL, V3, P473 Lambla NMK, 1998, POLYURETHANES BIOMED Lovice DB, 1999, OTOLARYNG CLIN N AM, V32, P113, DOI 10.1016/S0030-6665(05)70118-3 Maas C S, 1997, Facial Plast Surg, V13, P279, DOI 10.1055/s-0028-1082427 MANIGLIA AJ, 1989, LARYNGOSCOPE, V99, P865 Mendelsohn M, 1998, J OTOLARYNGOL, V27, P337 Romo T 3rd, 1998, Facial Plast Surg, V14, P151, DOI 10.1055/s-2008-1064339 SCHOENROCK LD, 1995, OTOLARYNG CLIN N AM, V28, P325 Silver WE, 1994, FACIAL PLAST SURG CL, V2, P477 Spiegel JH, 2005, OTOL NEUROTOL, V26, P563, DOI 10.1097/01.mao.0000169636.63440.4e Weber DE, 2006, LARYNGOSCOPE, V116, P700, DOI 10.1097/01.mlg.0000208549.44462.fa WILLIAMS KR, 1987, BIOMATERIALS, V8, P254, DOI 10.1016/0142-9612(87)90112-8 NR 22 TC 2 Z9 2 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD JUL PY 2013 VL 122 IS 7 BP 474 EP 479 PG 6 WC Otorhinolaryngology SC Otorhinolaryngology GA 184HM UT WOS:000321880700012 PM 23951702 ER PT J AU Cannon, DE Poetker, DM Loehrl, TA Chun, RH AF Cannon, Daniel E. Poetker, David M. Loehrl, Todd A. Chun, Robert H. TI Use of Coblation in Resection of Juvenile Nasopharyngeal Angiofibroma SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE angiofibroma; endoscopic surgery; nasal tumor; radiofrequency ablation AB We present a series of 4 patients with juvenile nasopharyngeal angiofibroma (JNA) who underwent Coblation-assisted endoscopic resection after preoperative embolization, and discuss the use and advantages of endoscopic Coblation-assisted resection of JNA. Our limited case series suggests that Coblation may be used in the resection of JNA after embolization in a relatively safe, efficient, and effective manner. Coblation allows for decreased bleeding, less need for instrumentation, and improved visualization. There are limited published data in the literature to date on the use of Coblation in endoscopic JNA resection. We describe its use in a more extensive tumor than those previously reported. Further studies are needed to fully define the safety and utility of Coblation technology for this application. C1 [Cannon, Daniel E.; Poetker, David M.; Loehrl, Todd A.; Chun, Robert H.] Med Coll Wisconsin, Dept Otolaryngol & Commun Sci, Milwaukee, WI 53226 USA. [Poetker, David M.; Loehrl, Todd A.] Med Coll Wisconsin, Div Rhinol & Sinus Surg, Milwaukee, WI 53226 USA. [Chun, Robert H.] Med Coll Wisconsin, Div Pediat Otolaryngol, Milwaukee, WI 53226 USA. Childrens Hosp Wisconsin, Milwaukee, WI 53201 USA. RP Chun, RH (reprint author), Childrens Hosp, Dept Otolaryngol, Clinics Bldg,Suite 350,9000 W Wisconsin Ave, Milwaukee, WI 53226 USA. CR Blount A, 2011, OTOLARYNG CLIN N AM, V44, P989, DOI 10.1016/j.otc.2011.06.003 Douglas Richard, 2006, Curr Opin Otolaryngol Head Neck Surg, V14, P1, DOI 10.1097/01.moo.0000188859.91607.65 Glad H, 2007, ACTA OTO-LARYNGOL, V127, P292, DOI 10.1080/00016480600818138 Nicolai P, 2010, AM J RHINOL ALLERGY, V24, pE67, DOI 10.2500/ajra.2010.24.3443 Pryor SG, 2005, LARYNGOSCOPE, V115, P1201, DOI 10.1097/01.MLG.0000162655.96247.66 Ruiz JW, 2012, INT J PEDIATR OTORHI, V76, P439, DOI 10.1016/j.ijporl.2011.11.005 Snyderman CH, 2010, ARCH OTOLARYNGOL, V136, P588, DOI 10.1001/archoto.2010.83 Syed MI, 2012, LARYNGOSCOPE, V122, P436, DOI 10.1002/lary.22420 Tewfik TL, 1999, J OTOLARYNGOL, V28, P145 Ye L, 2011, J LARYNGOL OTOL, V125, P940, DOI 10.1017/S0022215111001344 NR 10 TC 0 Z9 0 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD JUN PY 2013 VL 122 IS 6 BP 353 EP 357 PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA 164SP UT WOS:000320430100001 PM 23837385 ER PT J AU Brook, I Bogaardt, H van As-Brooks, C AF Brook, Itzhak Bogaardt, Hans van As-Brooks, Corina TI Long-Term Use of Heat and Moisture Exchangers Among Laryngectomees: Medical, Social, and Psychological Patterns SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE depression; heat and moisture exchanger; HME; laryngectomy; lung; speech ID AIR-FLOW RESISTANCE; PULMONARY REHABILITATION; HME AB Objectives: After laryngectomy, pulmonary protection is mostly acquired by means of a heat and moisture exchanger (HME) that is placed on an airtight seal around the stoma. The effects of HMEs on the tracheal climate have been well described, and the filtration effect of an HME with an electrostatic filter has been described in vitro. The effects of HME use in patients have been documented in several trials in different countries. The follow-up time of the patients in these trials, however, is limited. Less is known about long-term use of HMEs, and studies describing long-term compliance with HME use are scarce. This study investigated the long-term use of HMEs in laryngectomees. Methods: Questionnaires were sent to 195 laryngectomees, and 75 questionnaires were returned. Results: More than 85% of the respondents used an HME, of whom 77% were compliant users (ie, use for more than 20 hours per day). The incidence of pulmonary illnesses (either before or after surgery) was about 25%. More than 90% of the respondents were heavy smokers before laryngectomy. One third of the respondents are regularly exposed to dusty environments. Compliant HME users tend to make less use of external humidifiers and vaporizers, and have better pulmonary status and lower health-care costs. Regarding quality of life, patients who use a FreeHands device tended to have more frequent social contacts (r = 0.251; p = 0.030). The prevalence of depression is high, pointing to an urgent need to recognize and treat psychiatric problems such as depression and suicidal ideation in this patient group. Conclusions: These findings have implications for any postlaryngectomy research that uses pulmonary parameters. C1 [Brook, Itzhak] Georgetown Univ, Sch Med, Dept Pediat, Washington, DC 20007 USA. [Brook, Itzhak] Georgetown Univ, Sch Med, Dept Med, Washington, DC 20007 USA. [Bogaardt, Hans; van As-Brooks, Corina] Atos Med AB, Dept Clin Affairs, Horby, Sweden. [Bogaardt, Hans] HAN Univ Appl Sci, Inst Hlth Studies, Nijmegen, Netherlands. [van As-Brooks, Corina] Antoni van Leeuwenhoek Hosp, Netherlands Canc Inst, Dept Head & Neck Oncol & Surg, Amsterdam, Netherlands. RP Brook, I (reprint author), 4431 Albemarle St NW, Washington, DC 20016 USA. FU Atos Medical AB FX From the Departments of Pediatrics and Medicine, Georgetown University School of Medicine, Washington, DC (Brook), the Department of Clinical Affairs, Atos Medical AB, Horby, Sweden (Bogaardt, van As-Brooks), and the Institute of Health Studies, HAN University of Applied Sciences, Nijmegen (Bogaardt), and the Department of Head and Neck Oncology and Surgery, the Netherlands Cancer Institute/Antoni van Leeuwenhoek Hospital, Amsterdam (van As-Brooks), the Netherlands. This study was supported through a grant from Atos Medical AB. CR Ackerstaff A H, 1990, Ned Tijdschr Geneeskd, V134, P2438 Anguiano L, 2012, CANCER NURS, V35, pE14, DOI 10.1097/NCC.0b013e31822fc76c Bien S, 2010, EUR ARCH OTO-RHINO-L, V267, P429, DOI 10.1007/s00405-009-1018-4 Dassonville O, 2011, EUR ARCH OTO-RHINO-L, V268, P1647, DOI 10.1007/s00405-010-1474-x File T M, 2000, Semin Respir Infect, V15, P184 Grolman W, 1997, LARYNGOSCOPE, V107, P814, DOI 10.1097/00005537-199706000-00017 Herranz González-Botas J, 2001, Acta Otorrinolaringol Esp, V52, P221 Hilgers F J, 1990, Laryngoscope, V100, P1202 Hilgers FJM, 1997, ACTA OTO-LARYNGOL, V117, P889, DOI 10.3109/00016489709114220 HILGERS FJM, 1993, CLIN OTOLARYNGOL, V18, P517, DOI 10.1111/j.1365-2273.1993.tb00627.x HILGERS FJM, 1990, CLIN OTOLARYNGOL, V15, P421, DOI 10.1111/j.1365-2273.1990.tb00494.x Lorenz KJ, 2009, LARYNGO RHINO OTOL, V88, P513, DOI 10.1055/s-0029-1225619 Lydiatt William M, 2009, Clin Adv Hematol Oncol, V7, P397 Maddox PT, 2012, OTOLARYNG HEAD NECK, V147, P85, DOI 10.1177/0194599812438170 Masson Andrea Cristina Castelhano, 2008, Pro Fono, V20, P183, DOI 10.1590/S0104-56872008000300008 Merol JC, 2012, LARYNGOSCOPE, V122, P275, DOI 10.1002/lary.21841 MOHIDE EA, 1992, AM J SURG, V164, P619, DOI 10.1016/S0002-9610(05)80720-2 Mozolewski E, 1972, Otolaryngol Pol, V26, P653 Scheenstra RJ, 2010, ACTA OTO-LARYNGOL, V130, P739, DOI 10.3109/00016480903382790 Thomachot L, 1998, CHEST, V114, P1383, DOI 10.1378/chest.114.5.1383 Verkerke GJ, 2002, ANN OTO RHINOL LARYN, V111, P333 Verkerke GJ, 2001, ANN OTO RHINOL LARYN, V110, P639 Ward EC, 2007, HEAD NECK CANC TREAT Zuur JK, 2006, EUR ARCH OTO-RHINO-L, V263, P1, DOI 10.1007/s00405-005-0969-3 NR 24 TC 0 Z9 0 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD JUN PY 2013 VL 122 IS 6 BP 358 EP 363 PG 6 WC Otorhinolaryngology SC Otorhinolaryngology GA 164SP UT WOS:000320430100002 PM 23837386 ER PT J AU Achkar, J Dowdal, J Fink, D Franco, R Song, P AF Achkar, Jihad Dowdal, Jayme Fink, Daniel Franco, Ramon Song, Phillip TI Balloon Dilation Complication During the Treatment of Subglottic Stenosis: Background of the FDA Class 1 Recall for the 18 x 40-mm Acclarent Inspira AIR Balloon Dilation System SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE balloon dilation; idiopathic subglottic stenosis ID DILATATION; TRACHEOPLASTY; EXPERIENCE; MANAGEMENT; TRACHEAL AB Objectives: Balloon dilation for subglottic stenosis allows for a controlled radial expansion of the airway and is considered superior to older techniques of airway dilation. We report the case of a 39-year-old woman with idiopathic subglottic stenosis who had entrapment of an inflated balloon in her subglottis due to device failure while undergoing balloon dilation of the stenotic area. Methods: We present a case report and a review of the literature. Results: As a result of this and other reported incidents, on March 13, 2012, the US Food and Drug Administration issued a class 1 recall of the 18 x 40-mm Acclarent Inspira AIR Balloon Dilation System (Acclarent Inc, Menlo Park, California). Conclusions: This is the first report describing a dislodged inflated balloon in the subglottis as a complication of dilation for idiopathic subglottic stenosis. Awareness of this possibility, as well as preparedness with the proper instruments, is vital for prevention of a catastrophic emergency during an otherwise low-risk procedure. C1 [Achkar, Jihad; Dowdal, Jayme; Fink, Daniel; Franco, Ramon; Song, Phillip] Harvard Univ, Sch Med, Dept Otol & Laryngol, Div Laryngol, Boston, MA 02115 USA. RP Song, P (reprint author), 243 Charles St, Boston, MA 02114 USA. CR Andrews BT, 2007, LARYNGOSCOPE, V117, P2159 Bent JP, 2010, ANN OTO RHINOL LARYN, V119, P619 COHEN MD, 1984, AM J ROENTGENOL, V142, P477 GRILLO HC, 1993, ANN THORAC SURG, V56, P80 Hartnick CJ, 2001, ARCH OTOLARYNGOL, V127, P1260 HEBRA A, 1991, J PEDIATR SURG, V26, P957, DOI 10.1016/0022-3468(91)90843-I Klussmann JP, 2002, ANN OTO RHINOL LARYN, V111, P972 Lee KH, 2002, J VASC INTERV RADIOL, V13, P909, DOI 10.1016/S1051-0443(07)61774-6 Noppen M, 1997, CHEST, V112, P1136, DOI 10.1378/chest.112.4.1136 Perepelitsyn I, 2004, OTOLARYNG HEAD NECK, V131, P16, DOI 10.1016/j.otohns.2004.03.001 Schmidt B, 2001, ANN THORAC SURG, V71, P1630, DOI 10.1016/S0003-4975(01)02409-2 Watters K, 2008, INT J PEDIAT OTOLARY, V3, P39, DOI 10.1016/j.pedex.2007.09.006 NR 12 TC 0 Z9 0 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD JUN PY 2013 VL 122 IS 6 BP 364 EP 368 PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA 164SP UT WOS:000320430100003 PM 23837387 ER PT J AU Benito, J Espinoza, S Gutierrez-Fonseca, R Bagan, P Laccourreye, O AF Benito, Jose Espinoza, Sophie Gutierrez-Fonseca, Raimundo Bagan, Patrick Laccourreye, Ollvier TI Descending Mediastinitis With Mediastinal Abscess After Supracricoid Partial Laryngectomy SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE complication; mediastinitis; supracricoid partial laryngectomy ID NECROTIZING MEDIASTINITIS; MANAGEMENT; DEBRIDEMENT AB We document a rare and not-yet-reported condition after supracricoid partial laryngectomy: the development of descending mediastinitis with mediastinal abscess. We present a case in which early diagnosis and team management allowed for a successful outcome. The pathophysiology of this severe complication, as well as its diagnosis, management, and prevention, is discussed, together with a review of the medical scientific literature. C1 [Benito, Jose; Gutierrez-Fonseca, Raimundo; Laccourreye, Ollvier] Univ Paris Descartes Sorbonne Paris Cite, HEGP, AP HP, Dept Otorhinolaryngol Head & Neck Surg, Paris, France. [Espinoza, Sophie] Univ Paris Descartes Sorbonne Paris Cite, HEGP, AP HP, Dept Radiol, Paris, France. [Bagan, Patrick] Univ Paris Descartes Sorbonne Paris Cite, HEGP, AP HP, Dept Thorac Surg, Paris, France. RP Laccourreye, O (reprint author), HEGP, Dept Otorhinolaryngol Head & Neck Surg, 20-40 Rue Leblanc, F-75015 Paris, France. CR BARBOSADECARVAL.C, 2010, J BRAS PNEUMOL, V36, P812 Corsten MJ, 1997, THORAX, V52, P702 Das P, 2012, LARYNGOSCOPE, V122, P30, DOI 10.1002/lary.22453 De Freitas RP, 2007, EUR ARCH OTO-RHINO-L, V264, P181, DOI 10.1007/s00405-006-0174-z Deu-Martin M, 2010, ARCH BRONCONEUMOL, V46, P182, DOI 10.1016/j.arbres.2010.01.008 Endo S, 1999, Jpn J Thorac Cardiovasc Surg, V47, P14 Freeman RK, 2000, J THORAC CARDIOV SUR, V119, P260, DOI 10.1016/S0022-5223(00)70181-4 Gaudino M, 2009, J CARDIAC SURG, V24, P632, DOI 10.1111/j.1540-8191.2009.00907.x Halum SL, 2012, LARYNGOSCOPE, V122, P38, DOI 10.1002/lary.22364 Holsinger FC, 2005, J AM COLL SURGEONS, V201, P809, DOI 10.1016/j.jamcollsurg.2005.06.260 Isowa N, 2004, ANN THORAC SURG, V77, P1834, DOI 10.1016/S0003-4975(03)01260-8 Karkas A, 2010, BRIT J SURG, V97, P609, DOI 10.1002/bjs.6935 Kiernan PD, 1998, ANN THORAC SURG, V65, P1483, DOI 10.1016/S0003-4975(98)00142-8 LACCOURREYE H, 1990, Annals of Otology Rhinology and Laryngology, V99, P421 LACCOURREYE O, 1994, ACTA OTO-LARYNGOL, V114, P669, DOI 10.3109/00016489409126124 Makeieff M, 2004, LARYNGOSCOPE, V114, P772, DOI 10.1097/00005537-200404000-00035 Min HK, 2004, ANN THORAC SURG, V77, P306, DOI 10.1016/S0003-4975(03)01333-X Mora R, 2004, ENT-EAR NOSE THROAT, V83, P776 Nakamura Yukio, 2009, Gen Thorac Cardiovasc Surg, V57, P111, DOI 10.1007/s11748-008-0328-6 Nikolaos Nikolaos D, 2007, Med Sci Monit, V13, pCS83 Papalia E, 2001, EUR J CARDIO-THORAC, V20, P739, DOI 10.1016/S1010-7940(01)00790-4 Rein Susanne, 2010, J Med Case Rep, V4, P364, DOI 10.1186/1752-1947-4-364 Ridder GJ, 2010, ANN SURG, V251, P528, DOI 10.1097/SLA.0b013e3181c1b0d1 Sobin LH, 2002, UICC TNM CLASSIFICAT Vieira F, 2008, OTOLARYNG CLIN N AM, V41, P459, DOI 10.1016/j.otc.2008.01.002 NR 25 TC 0 Z9 0 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD JUN PY 2013 VL 122 IS 6 BP 369 EP 373 PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA 164SP UT WOS:000320430100004 PM 23837388 ER PT J AU Krouchi, L Callonnec, F Bouchetemble, P Tollard, E Dehesdin, D Marie, JP AF Krouchi, Lydia Callonnec, Francoise Bouchetemble, Pierre Tollard, Eleonore Dehesdin, Daniele Marie, Jean-Paul TI Preoperative Computed Tomography Scan May Fail to Predict Perilymphatic Gusher SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE gusher; otosclerosis; surgery ID SENSORINEURAL HEARING-LOSS; LARGE VESTIBULAR AQUEDUCT AB Objectives: A stapes gusher is a very rare event in ear surgery, but the consequences for hearing can be dramatic. It can usually be predicted by characteristic radiologic abnormalities. We report 2 cases of gusher without any abnormalities seen on the preoperative computed tomography scans. Methods: The first case was in a 30-year-old man with a bilateral mixed hearing loss. The gusher occurred after a stapedotomy performed with a microdrill. The oval window was plugged with a vein graft, and a fluoroplastic piston was inserted. The second case was in a 39-year-old woman with a family history of hearing loss who presented with a bilateral mixed hearing loss. The footplate was fractured during the stapedotomy drilling and was covered with a temporalis fascia graft that was fixed with a fluoroplastic piston. Results: The first patient had no cerebrospinal fluid leakage and no vertigo or tinnitus. He did have a sensorineural hearing loss. The second patient had dizziness and tinnitus. Postoperative magnetic resonance imaging scans were performed, but again no features were identified that might have predicted these cases. Conclusions: Surgeons should be reminded that a preoperative computed tomography scan may fail to detect the risk of a perilymphatic gusher. C1 [Krouchi, Lydia; Bouchetemble, Pierre; Dehesdin, Daniele; Marie, Jean-Paul] Rouen Univ Hosp Charles Nicolle, Dept Otolaryngol Head & Neck Surg, F-76031 Rouen, France. [Tollard, Eleonore] Rouen Univ Hosp Charles Nicolle, Dept Radiol, F-76031 Rouen, France. [Callonnec, Francoise] Ctr Henri Becquerel, Dept Radiol, F-76038 Rouen, France. RP Marie, JP (reprint author), Rouen Univ Hosp Charles Nicolle, Dept Otolaryngol Head & Neck Surg, 1 Rue Germont, F-76031 Rouen, France. CR Chen JL, 2008, ARCH OTOLARYNGOL, V34, P50 Couvreur Ph, 2003, Rev Laryngol Otol Rhinol (Bord), V124, P31 Lemmerling MM, 1997, RADIOLOGY, V204, P213 McClay JE, 2002, ARCH OTOLARYNGOL, V128, P664 McFadden MD, 2005, ENT-EAR NOSE THROAT, V84, P772 Purcell DD, 2006, LARYNGOSCOPE, V116, P1439, DOI 10.1097/01.mlg.0000229826.96593.13 Schuknecht H F, 1988, Adv Otorhinolaryngol, V39, P1 VALVASSORI GE, 1978, LARYNGOSCOPE, V88, P723 Veillon F, 1991, IMAGERIE OREILLE Wootten CT, 2006, LARYNGOSCOPE, V116, P2055, DOI 10.1097/01.ndg.0000240286.43289.87 NR 10 TC 0 Z9 0 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD JUN PY 2013 VL 122 IS 6 BP 374 EP 377 PG 4 WC Otorhinolaryngology SC Otorhinolaryngology GA 164SP UT WOS:000320430100005 PM 23837389 ER PT J AU Vasileiadis, I Kapetanakis, S Vasileiadis, D Petousis, A Karatzas, T AF Vasileiadis, Ioannis Kapetanakis, Stylianos Vasileiadis, Dimitrios Petousis, Aristotelis Karatzas, Theodore TI External Auditory Canal Mass as the First Manifestation of a Bronchogenic Carcinoma: Report of a Rare Case SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article; Proceedings Paper CT 28th Politzer-Society Meeting CY SEP 28-OCT 01, 2011 CL Athens, GREECE SP Politzer Soc DE aural mass; bronchogenic adenocarcinoma; external auditory canal; metastatic tumor ID RENAL-CELL CARCINOMA; TEMPORAL BONE; ADENOCARCINOMA; METASTASIS AB Objectives: Metastatic tumors in the external auditory canal (EAC) are exceptionally rare. These metastases almost always occur in the latter stages of the disease process. Ten cases of metastatic tumors of the EAC have been reported in the literature. We report the first case of a metastatic bronchogenic adenocarcinoma that presented initially as an EAC mass. Methods: We present a case report and a literature review. Results: Although bronchogenic adenocarcinoma not uncommonly metastasizes to the temporal bone, metastasis to the EAC is extremely rare. We report the case of a 62-year-old woman who presented with a 6-week history of swelling in her right EAC and sudden onset of hearing loss. Physical examination revealed a small, polypoid, friable mass originating from the superior-posterior wall of the right EAC. Incision biopsy was performed, and the histopathologic examination of specimens revealed a moderately to poorly differentiated adenocarcinoma compatible with a bronchogenic origin. Conclusions: A patient with an aural mass presents a diagnostic dilemma. Metastatic tumors in the EAC are extremely rare, but they should be included in the differential diagnosis of a mass in this location. C1 [Vasileiadis, Ioannis; Petousis, Aristotelis] Venizeleio Pananeio Gen Hosp, Dept Otolaryngol Head & Neck Surg, Iraklion 71409, Greece. [Vasileiadis, Ioannis; Kapetanakis, Stylianos; Vasileiadis, Dimitrios] Democritus Univ Thrace, Med Sch Alexandroupoli, Dept Anat, Alexandroupolis, Greece. [Karatzas, Theodore] Univ Athens, Sch Med, Laiko Gen Hosp, Dept Propedeut Surg 2, GR-11527 Athens, Greece. RP Vasileiadis, I (reprint author), Venizeleio Pananeio Gen Hosp, Dept Otolaryngol Head & Neck Surg, Iraklion 71409, Greece. CR Alberg AJ, 2007, CHEST, V132, p29S, DOI 10.1378/chest.07-1347 Balm A, 2010, INT J SURG ONCOL, V2010, DOI DOI 10.1155/2010/581540 Calabrese L, 2005, Acta Otorhinolaryngol Ital, V25, P2 Carr S, 2009, J LARYNGOL OTOL, V123, P363, DOI 10.1017/S0022215108002867 Carson Henry J, 2005, Ear Nose Throat J, V84, P36 Cheng AG, 2007, AM J OTOLARYNG, V28, P433, DOI 10.1016/j.amjoto.2006.11.006 CUMBERWORTH VL, 1994, J LARYNGOL OTOL, V108, P808 Dev D, 1996, RESP MED, V90, P333, DOI 10.1016/S0954-6111(96)90128-6 Devaney K, 2005, LANCET ONCOL, V6, P411, DOI 10.1016/S1470-2045(05)70208-4 Gloria-Cruz TI, 2000, ARCH OTOLARYNGOL, V126, P209 GOLDMAN NC, 1992, OTOLARYNG HEAD NECK, V106, P410 Imauchi Y, 2001, AURIS NASUS LARYNX, V28, P169, DOI 10.1016/S0385-8146(00)00109-7 Ingelaere PPC, 1997, J LARYNGOL OTOL, V111, P1066 Lollar KW, 2010, OTOLARYNG HEAD NECK, V142, P298, DOI 10.1016/j.otohns.2009.07.017 Michaelson PG, 2005, OTOLARYNG HEAD NECK, V133, P979, DOI 10.1016/j.otohns.2005.07.002 Prasannaraj T, 2003, AM J OTOLARYNG, V24, P155, DOI 10.1016/S0196-0709(03)32426-8 Shrivastava V, 2007, CLIN GENITOURIN CANC, V5, P341, DOI 10.3816/CGC.2007.n.015 Streitmann MJ, 1996, AM J OTOL, V17, P780 Yasumatsu R, 2007, WORLD J GASTROENTERO, V13, P6436, DOI 10.3748/wjg.13.6436 NR 19 TC 0 Z9 0 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD JUN PY 2013 VL 122 IS 6 BP 378 EP 381 PG 4 WC Otorhinolaryngology SC Otorhinolaryngology GA 164SP UT WOS:000320430100006 PM 23837390 ER PT J AU Le Treut, C Rome, A Cassagneau, P Fernandez, C Triglia, JM Nicollas, R AF Le Treut, Claire Rome, Angelique Cassagneau, Pierre Fernandez, Carla Triglia, Jean-Michel Nicollas, Richard TI Rhabdomyosarcoma of Stensen's Duct in Children SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE face; malignancy; parotid gland; pediatrics ID NECK-RHABDOMYOSARCOMA; HEAD AB Objectives: Stensen's duct is a very uncommon location for rhabdomyosarcoma. The purpose of this article was to review the clinical history of 2 patients who had rhabdomyosarcoma of Stensen's duct. Methods: We reviewed the clinical history, imaging studies, histologic analysis, and treatment of 2 patients with rhabdomyosarcoma of Stensen's duct. Results: An 8-year-old boy (case 1) and a 17-year-old boy (case 2) presented with nonspecific facial swelling. In both patients, imaging studies showed a tumor at Stensen's duct, and biopsy showed embryonal rhabdomyosarcoma. Both patients were treated with preoperative chemotherapy, parotidectomy, and resection of Stensen's duct and postoperative chemotherapy and radiation therapy. Follow-up at 9 years (case 1) and 2 years (case 2) after surgery showed that the patients were free of disease. Conclusions: Stensen's duct rhabdomyosarcoma is rare and may have a better prognosis than rhabdomyosarcoma in other locations in the head and neck. C1 [Le Treut, Claire; Triglia, Jean-Michel; Nicollas, Richard] La Timone Childrens Hosp, Dept Pediat Otolaryngol Head & Neck Surg, Marseille, France. [Rome, Angelique] La Timone Childrens Hosp, Dept Pediat Oncol, Marseille, France. [Cassagneau, Pierre] La Timone Hosp, Dept Radiol, Marseille, France. [Fernandez, Carla] La Timone Hosp, Dept Pathol, Marseille, France. Aix Marseille Univ, Marseille, France. RP Nicollas, R (reprint author), Aix Marseille Univ, La Timone Childrens Hosp, Dept Pediat Otolaryngol Head & Neck Surg, 264 Rue St Pierre, F-13385 Marseille 5, France. CR Andrade Cléverton Roberto de, 2010, Braz Dent J, V21, P68, DOI 10.1590/S0103-64402010000100011 BenJelloun H, 2005, Cancer Radiother, V9, P316, DOI 10.1016/j.canrad.2005.04.004 Combs SE, 2007, BMC CANCER, V7, DOI 10.1186/1471-2407-7-177 Gradoni P, 2010, SURG ONCOL, V19, pE103, DOI 10.1016/j.suronc.2010.01.006 Kapadia SB, 1996, AM J OTOLARYNG, V17, P127, DOI 10.1016/S0196-0709(96)90009-5 Moretti G, 2010, BRAZ J OTORHINOLAR, V76, P533, DOI 10.1590/S1808-86942010000400020 Sengupta Subhabrata, 2009, J Indian Assoc Pediatr Surg, V14, P200, DOI 10.4103/0971-9261.59601 NR 7 TC 0 Z9 0 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD JUN PY 2013 VL 122 IS 6 BP 382 EP 385 PG 4 WC Otorhinolaryngology SC Otorhinolaryngology GA 164SP UT WOS:000320430100007 PM 23837391 ER PT J AU Lazarus, CL Husaini, H Anand, SM Jacobson, AS Mojica, JK Buchbinder, D Urken, ML AF Lazarus, Cathy L. Husaini, Hasan Anand, Sumeet M. Jacobson, Adam S. Mojica, Jackie K. Buchbinder, Daniel Urken, Mark L. TI Tongue Strength as a Predictor of Functional Outcomes and Quality of Life After Tongue Cancer Surgery SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE oral cancer; outcome; quality of life; tongue strength ID FOREARM FREE-FLAP; OROPHARYNGEAL CANCER; NECK-CANCER; ORAL-CAVITY; SWALLOWING FUNCTION; ADVANCED HEAD; FOLLOW-UP; SPEECH; RECONSTRUCTION; RADIOTHERAPY AB Objectives: Surgical resection of oral cancer can result in altered speech, swallowing, and quality of life (QOL). To date, the oral outcome variables of tongue strength, tongue and jaw range of motion, and saliva production have not been extensively assessed. This pilot study was done to assess tongue strength along with other oral outcomes and their relationship to performance status for speech, swallowing, and QOL after partial glossectomy. Our aim was to create a norm for what should be considered a normal tongue strength value in this population. We hypothesized that patients with tongue strength of 30 kPa or greater would perform better on the performance status scale and various QOL measures than do patients with tongue strength of less than 30 kPa. Methods: We used a cross-sectional design in this study. The postoperative assessment included 1) Performance Status Scale and Karnofsky Performance Status Scale; 2) oral outcome variables of tongue strength, jaw range of motion, and saliva production; and 3) patient-rated QOL ratings via Eating Assessment Tool, M. D. Anderson Dysphagia Inventory, EORTC-H&N35, and Speech Handicap Index. Results: Patients with tongue strength of at least 30 kPa performed better on the performance status scales and various QOL measures. The cutoff score of 30 kPa for tongue strength measures revealed a trend in predicting performance on the scales and QOL measures. Conclusions: The oral outcome variables correlated with performance status for speech, swallowing, and QOL. We propose a norm for tongue strength in this population, based on the trend seen in this group of patients, as none previously existed. Future studies are under way that incorporate a larger sample size to further validate this norm. Future studies will also examine oral functional outcome measures in a larger population by including other oral and oropharyngeal sites to help predict speech and swallow performance status and QOL. C1 [Lazarus, Cathy L.; Husaini, Hasan; Anand, Sumeet M.; Jacobson, Adam S.; Mojica, Jackie K.; Buchbinder, Daniel; Urken, Mark L.] Beth Israel Deaconess Med Ctr, Thyroid Head & Neck Canc Fdn, New York, NY 10003 USA. [Lazarus, Cathy L.; Anand, Sumeet M.; Jacobson, Adam S.; Mojica, Jackie K.; Buchbinder, Daniel; Urken, Mark L.] Beth Israel Deaconess Med Ctr, Dept Otolaryngol Head & Neck Surg, New York, NY 10003 USA. [Lazarus, Cathy L.; Anand, Sumeet M.; Jacobson, Adam S.; Buchbinder, Daniel; Urken, Mark L.] Yeshiva Univ, Albert Einstein Coll Med, Dept Otorhinolaryngol Head & Neck Surg, New York, NY 10033 USA. RP Lazarus, CL (reprint author), Beth Israel Deaconess Med Ctr, Thyroid Head & Neck Canc Fdn, 10 Union Sq East,Suite 5B, New York, NY 10003 USA. CR Belafsky PC, 2008, ANN OTO RHINOL LARYN, V117, P919 Biazevic MGH, 2010, J APPL ORAL SCI, V18, P279, DOI 10.1590/S1678-77572010000300015 Brown L, 2010, J ORAL MAXIL SURG, V68, P2690, DOI 10.1016/j.joms.2010.05.004 Butler SG, 2011, J GERONTOL A-BIOL, V66, P452, DOI 10.1093/gerona/glq234 Chen AY, 2001, ARCH OTOLARYNGOL, V127, P870 Chen PH, 2009, DYSPHAGIA, V24, P1, DOI 10.1007/s00455-008-9156-1 Chepeha DB, 2008, ARCH OTOLARYNGOL, V134, P993, DOI 10.1001/archotol.134.9.993 Clark HM, 2003, AM J SPEECH-LANG PAT, V12, P40, DOI 10.1044/1058-0360(2003/051) Connor NP, 2006, INT J RADIAT ONCOL, V65, P1051, DOI 10.1016/j.ijrobp.2006.01.054 de Graeff A, 1999, HEAD NECK-J SCI SPEC, V21, P291, DOI 10.1002/(SICI)1097-0347(199907)21:4<291::AID-HED1>3.0.CO;2-B DODDS WJ, 1990, AM J ROENTGENOL, V154, P953 Dwivedi RC, 2012, EUR ARCH OTO-RHINO-L, V269, P1233, DOI 10.1007/s00405-011-1756-y Dwivedi RC, 2011, HEAD NECK-J SCI SPEC, V33, P341, DOI 10.1002/hed.21450 Furia CLB, 2000, ARCH OTOLARYNGOL, V126, P378 Furia CLB, 2001, ARCH OTOLARYNGOL, V127, P877 Hamlet S, 1997, INT J RADIAT ONCOL, V37, P789, DOI 10.1016/S0360-3016(96)00604-9 Hanasono MM, 2009, HEAD NECK-J SCI SPEC, V31, P1289, DOI 10.1002/hed.21100 IMAI S, 1992, J SPEECH HEAR RES, V35, P68 Jham BC, 2008, CLIN ORAL INVEST, V12, P19, DOI 10.1007/s00784-007-0149-5 KOHLER PF, 1985, ARTHRITIS RHEUM, V28, P1128, DOI 10.1002/art.1780281008 Lazarus C, 2007, HEAD NECK-J SCI SPEC, V29, P632, DOI 10.1002/hed.20577 Lazarus Cathy, 2006, Seminars in Speech and Language, V27, P260, DOI 10.1055/s-2006-955116 Lazarus CL, 2000, J SPEECH LANG HEAR R, V43, P1011 LIST MA, 1990, CANCER, V66, P564, DOI 10.1002/1097-0142(19900801)66:3<564::AID-CNCR2820660326>3.0.CO;2-D List MA, 1999, J CLIN ONCOL, V17, P1020 Logemann JA, 1997, ONCOLOGY WILLISTON P, V11, P651 Machtay M, 2008, J CLIN ONCOL, V26, P3582, DOI 10.1200/JCO.2007.14.8841 Magne P, 2003, J PROSTHET DENT, V89, P453, DOI 10.1016/S0022-3913(03)00125-2 McConnel FMS, 1998, ARCH OTOLARYNGOL, V124, P625 MICHIWAKI Y, 1990, J CRANIO MAXILL SURG, V18, P164, DOI 10.1016/S1010-5182(05)80512-8 NAVAZESH M, 1982, J DENT RES, V61, P1158, DOI 10.1177/00220345820610100901 Nicosia MA, 2000, J GERONTOL A-BIOL, V55, pM634 Oates JE, 2007, ARCH OTOLARYNGOL, V133, P533, DOI 10.1001/archotol.133.6.533 Pauloski BR, 2000, HEAD NECK-J SCI SPEC, V22, P120, DOI 10.1002/(SICI)1097-0347(200003)22:2<120::AID-HED3>3.0.CO;2-U PAULOSKI BR, 1994, HEAD NECK-J SCI SPEC, V16, P313, DOI 10.1002/hed.2880160404 Pauloski BR, 1998, OTOLARYNG HEAD NECK, V118, P616, DOI 10.1177/019459989811800509 PAULOSKI BR, 1993, J SPEECH HEAR RES, V36, P267 Pauloski BR, 1998, LARYNGOSCOPE, V108, P908, DOI 10.1097/00005537-199806000-00022 RENTSCHLER GJ, 1980, J ORAL SURG, V38, P348 Rieger JM, 2007, HEAD NECK-J SCI SPEC, V29, P1024, DOI 10.1002/hed.20623 Rinkel RN, 2008, HEAD NECK-J SCI SPEC, V30, P868, DOI 10.1002/hed.20795 Robbins J, 2007, ARCH PHYS MED REHAB, V88, P150, DOI 10.1016/j.apmr.2006.11.002 ROBBINS J, 1995, J GERONTOL A-BIOL, V50, pM257 ROBIN DA, 1992, J SPEECH HEAR RES, V35, P1239 SCHAG CC, 1984, J CLIN ONCOL, V2, P187 Seikaly H, 2003, LARYNGOSCOPE, V113, P897, DOI 10.1097/00005537-200305000-00023 Sherman AC, 2000, ARCH OTOLARYNGOL, V126, P459 Shin YS, 2012, J ORAL MAXIL SURG, V70, P216, DOI 10.1016/j.joms.2011.04.014 Solomon NP, 2004, J SPEECH LANG HEAR R, V47, P584, DOI 10.1044/1092-4388(2004/045) Stierwalt JAG, 2007, AM J SPEECH-LANG PAT, V16, P148, DOI 10.1044/1058-0360(2007/019) Suarez-Cunqueiro MM, 2008, ARCH OTOLARYNGOL, V134, P1299, DOI 10.1001/archotol.134.12.1299 Teguh DN, 2008, INT J RADIAT ONCOL, V72, P1119, DOI 10.1016/j.ijrobp.2008.02.061 Urken ML, 2010, MULTIDISCIPLINARY HE, P235 URKEN ML, 1994, ARCH OTOLARYNGOL, V120, P589 Weber Clemens, 2010, Oral Maxillofac Surg, V14, P169, DOI 10.1007/s10006-010-0220-2 Yang ZH, 2010, J ORAL MAXIL SURG, V68, P2164, DOI 10.1016/j.joms.2009.09.048 Zelefsky MJ, 1996, AM J SURG, V171, P258, DOI 10.1016/S0002-9610(97)89563-3 NR 57 TC 4 Z9 4 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD JUN PY 2013 VL 122 IS 6 BP 386 EP 397 PG 12 WC Otorhinolaryngology SC Otorhinolaryngology GA 164SP UT WOS:000320430100008 PM 23837392 ER PT J AU More, Y Shnayder, Y Girod, DA Sykes, KJ Carlisle, MP Chalmers, B Kraemer, C Tsue, TT AF More, Yogesh Shnayder, Yelizaveta Girod, Douglas A. Sykes, Kevin J. Carlisle, Michael P. Chalmers, Brian Kraemer, CodyJo Tsue, Terance T. TI Factors Influencing Morbidity After Surgical Management of Malignant Thyroid Disease SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article; Proceedings Paper CT 8th International Conference on Head and Neck Cancer of the American-Head-and-Neck-Society CY JUL 21-25, 2012 CL Toronto, CANADA SP Amer Head & Neck Soc DE hypoparathyroidism; recurrent laryngeal nerve; thyroid malignancy ID RECURRENT LARYNGEAL NERVE; NECK-DISSECTION; CARCINOMA; PAPILLARY; SURGERY; CANCER; COMPLICATIONS; THERAPY; PALSY AB Objectives: We performed a retrospective study of cases from 2005 to 2010 at an academic tertiary care center to analyze the factors that influence morbidity in surgical management of thyroid malignancy. Methods: The rates of recurrent laryngeal nerve (RLN) injury and hypoparathyroidism (HPT) were analyzed in the entire cohort. The comparison groups were 1) primary surgery versus revision; 2) total thyroidectomy versus total thyroidectomy combined with neck node dissection; and 3) two groups defined by surgical technique according to the RLN approach: group 1, in which the RLN was identified inferiorly in the tracheoesophageal groove, and group 2, in which the RLN was identified near the cricothyroid joint point of entry. Results: We reviewed 308 patients who underwent surgery for thyroid cancer. Thirty-six (11.7%) had temporary HPT, and 8 (2.6%) had permanent HPT. Of a total of 586 RLNs at risk, 16 (2.7%) had temporary damage and 2 (0.3%) had permanent damage. The incidences of temporary RLN injury significantly differed between the primary-surgery and revision-surgery groups (2.5% versus 15.6%; p = 0.001), and also between the groups with total thyroidectomy and thyroidectomy with neck dissection (1.2% versus 7.8%; p = 0.027). The incidences of temporary HPT were significantly different between the groups with primary surgery and revision surgery (6.6% versus 31.3%; p = 0.001), between the groups with total thyroidectomy and total thyroidectomy with neck dissection (4.7% versus 15.6%; p = 0.009), and between group 1 and group 2 (surgical technique in terms of RLN approach; 8.2% versus 17.9%; p = 0.011). Permanent HPT and permanent RLN injury both occurred rarely in this cohort, with no significant differences among comparison groups. Conclusions: Our study shows a higher incidence of temporary RLN injury and temporary HPT in revision surgery cases and in total thyroidectomy with neck dissection. Temporary HPT was significantly more common when the RLN was identified near the cricothyroid joint. C1 [More, Yogesh; Shnayder, Yelizaveta; Girod, Douglas A.; Sykes, Kevin J.; Carlisle, Michael P.; Chalmers, Brian; Kraemer, CodyJo; Tsue, Terance T.] Univ Kansas, Med Ctr, Dept Otolaryngol, Kansas City, KS 66103 USA. RP More, Y (reprint author), Univ Kansas, Med Ctr, Dept Otolaryngol, MS 3010,3901 Rainbow Blvd, Kansas City, KS 66103 USA. RI Sykes, Kevin/D-5897-2013 OI Sykes, Kevin/0000-0001-9379-3406 CR Alveryd A, 1968, Acta Chir Scand, V389, P1 BALLANTYNE AJ, 1991, SEMIN SURG ONCOL, V7, P100, DOI 10.1002/ssu.2980070210 Bergamaschi R, 1998, AM J SURG, V176, P71, DOI 10.1016/S0002-9610(98)00099-3 Carling T, 2005, CANC PRINCIPLES PRAC, P1502 Clark OH, 2005, TXB ENDOCRINE SURG, P110, DOI 10.1016/B978-0-7216-0139-7.50016-8 CLARK OH, 1982, ANN SURG, V196, P361, DOI 10.1097/00000658-198209000-00016 Dener C, 2002, ACTA OTO-LARYNGOL, V122, P679, DOI 10.1080/000164802320396394 Erbil Y, 2007, CLIN OTOLARYNGOL, V32, P32, DOI 10.1111/j.1365-2273.2007.01383.x Grebe S K, 1996, Surg Oncol Clin N Am, V5, P43 Henry JF, 1998, LANGENBECK ARCH SURG, V383, P167, DOI 10.1007/s004230050111 KATZ AD, 1993, AM SURGEON, V59, P188 Lai SY, 2010, CUMMINGS OTOLARYNGOL, P1760 LEKACOS NL, 1992, INT SURG, V77, P287 MAZZAFERRI EL, 1994, AM J MED, V97, P418, DOI 10.1016/0002-9343(94)90321-2 Menegaux F, 2001, INT J SURG INVESTIG, V2, P107 Noguchi S, 1998, ARCH SURG-CHICAGO, V133, P276, DOI 10.1001/archsurg.133.3.276 Osmólski Antoni, 2006, Otolaryngol Pol, V60, P165 Palme CE, 2005, J OTOLARYNGOL, V34, P7, DOI 10.2310/7070.2005.03048 REEVE TS, 1986, AUST NZ J SURG, V56, P829, DOI 10.1111/j.1445-2197.1986.tb01834.x Roh JL, 2007, ANN SURG, V245, P604, DOI 10.1097/01.sla.0000250451.59685.67 Roher HD, 1999, CHIRURG, V70, P999 Sancho JJ, 2008, BRIT J SURG, V95, P961, DOI 10.1002/bjs.6173 Serpell JW, 2009, ANN SURG, V249, P648, DOI 10.1097/SLA.0b013e31819ed9a4 Shindo ML, 2005, OTOLARYNG HEAD NECK, V133, P514, DOI 10.1016/j.otohns.2005.07.010 Simon MM, 1943, AM J SURG, V60, P212, DOI 10.1016/S0002-9610(43)90652-X Spear SA, 2008, MIL MED, V173, P399 Toniato A, 2008, WORLD J SURG, V32, P572, DOI 10.1007/s00268-007-9362-2 Veyseller B, 2011, ARCH OTOLARYNGOL, V137, P897, DOI 10.1001/archoto.2011.134 NR 28 TC 2 Z9 2 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD JUN PY 2013 VL 122 IS 6 BP 398 EP 403 PG 6 WC Otorhinolaryngology SC Otorhinolaryngology GA 164SP UT WOS:000320430100009 PM 23837393 ER PT J AU Merrill, RM Roy, N Lowe, J AF Merrill, Ray M. Roy, Nelson Lowe, Jessica TI Voice-Related Symptoms and Their Effects on Quality of Life SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE aging and health; quality of life; voice disorder ID GENERAL-POPULATION; RISK-FACTORS; DISORDERS; TEACHERS; PREVALENCE; DYSPHONIA; IMPACT AB Objectives: The purpose of this study was to identify the extent to which selected voice symptoms formed underlying constructs called factors, and the degree to which these factors influenced specific quality-of-life domains among a group of relatively healthy older adults. Methods: A cross-sectional survey was completed in October 2010 by 461 individuals 50 years of age and older. The questionnaire items included demographics, medical history, health, voice use, and voice symptoms. Quality-of-life indicators were used from the Short Form 36 Health Survey, an 8-scale measure of functional health and well-being. Results: Two clusters of symptoms were identified in the factor analysis. One cluster, consisting of 5 voice-related symptoms and labeled "phonatory effort," shared all significant negative correlations with health outcomes, whereas the other cluster, consisting of 2 voice-related symptoms and labeled "chronic throat condition," had a pattern of sharing significant negative correlations with only 3 health outcomes. All voice symptoms had significant negative correlations with general health, bodily pain, and energy/fatigue. Conclusions: Voice-related symptoms share complex relationships with and have negative effects on health outcomes. The specific mechanisms of impact need further research in order for us to better understand these effects on quality of life and how to prevent and treat the symptoms. C1 [Merrill, Ray M.; Lowe, Jessica] Brigham Young Univ, Dept Hlth Sci, Provo, UT 84602 USA. [Roy, Nelson] Univ Utah, Dept Commun Sci & Disorders, Salt Lake City, UT USA. RP Merrill, RM (reprint author), Brigham Young Univ, Dept Hlth Sci, Provo, UT 84602 USA. CR Behrman A, 2004, LARYNGOSCOPE, V114, P1693, DOI 10.1097/00005537-200410000-00004 Benninger MS, 1998, J VOICE, V12, P540, DOI 10.1016/S0892-1997(98)80063-5 Cohen SM, 2006, ANN OTO RHINOL LARYN, V115, P128 Definitions of communication disorders and variations, 1993, AM SPEECH LANGUA S10, V35, P40 Eadie TL, 2010, J VOICE, V24, P564, DOI 10.1016/j.jvoice.2008.12.005 Eadie TL, 2007, ANN OTO RHINOL LARYN, V116, P695 Harman H., 1976, MODERN FACTOR ANAL HERRINGTONHALL BL, 1988, J SPEECH HEAR DISORD, V53, P57 Merrill RM, 2011, LARYNGOSCOPE, V121, P2004, DOI 10.1002/lary.21895 Mulaik S, 1972, FDN FACTOR ANAL RAMIG LA, 1983, J SPEECH HEAR RES, V26, P22 RAND Corporation, MED OUTC STUD 36 IT Roy N, 2007, LARYNGOSCOPE, V117, P628, DOI 10.1097/MLG.0b013e3180306da1 Roy N, 2004, J SPEECH LANG HEAR R, V47, P281, DOI 10.1044/1092-4388(2004/023) Roy N, 2004, J SPEECH LANG HEAR R, V47, P542, DOI 10.1044/1092-4388(2004/042) Roy N, 2005, LARYNGOSCOPE, V115, P1988, DOI 10.1097/01.mlg.0000179174.32345.41 Thibeault SL, 2004, ANN EPIDEMIOL, V14, P786, DOI 10.1016/j.annepidem.2004.03.004 WARE JE, 1994, INT J MENT HEALTH, V23, P49 Ware JE, 1993, SF 36 HLTH SURVEY MA Ware JE, 2001, SF 36 PHYS MENTAL HL, V2nd NR 20 TC 0 Z9 0 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD JUN PY 2013 VL 122 IS 6 BP 404 EP 411 PG 8 WC Otorhinolaryngology SC Otorhinolaryngology GA 164SP UT WOS:000320430100010 PM 23837394 ER PT J AU Bush, ML Bingcang, CM Chang, ET Fomwalt, B Rayle, C Gal, TJ Jones, RO Shinn, JB AF Bush, Matthew L. Bingcang, Christopher M. Chang, Edward T. Fomwalt, Brandon Rayle, Christopher Gal, Thomas J. Jones, Raleigh O. Shinn, Jennifer B. TI Hot or Cold? Is Monothermal Caloric Testing Useful and Cost-Effective? SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article; Proceedings Paper CT Meeting of the American-Auditory-Society CY MAR 08-10, 2012 CL Scottsdale, AZ SP Amer Auditory Soc DE cost-effectiveness; electronystagmography; monothermal caloric testing; videonystagmography ID SCREENING-TEST; VESTIBULAR FUNCTION AB Objectives: Videonystagmography (VNG) is used widely in the assessment of balance dysfunction. The full test battery can be time-consuming and can induce patient discomfort. The purpose of this study was to examine the value of monothermal caloric testing in predicting unilateral caloric weakness, as well as abnormal VNG vestibular and nonvestibular eye movement, while considering the time and reimbursement associated with these tests. Methods: In a retrospective review of 645 patients who completed a comprehensive VNG test battery with bithermal caloric testing, we calculated the specificity, sensitivity, and predictive values of monothermal caloric testing in relation to bithermal caloric results and noncaloric VNG results. Results: With unilateral vestibular weakness (UVW) defined as a 25% interear difference, warm-air monothermal caloric testing yielded a sensitivity of 87% and a negative predictive value of 90% for predicting UVW. With a 10% UVW definition, the warm-air caloric testing sensitivity increased to 95% and the negative predictive value to 92%. Warm-air monothermal caloric testing had a positive predictive value of 85% and a negative predictive value of 18% for predicting noncaloric VNG findings; cold-air monothermal and bithermal testing displayed similar results. Conclusions: Isolated monothermal testing is a sensitive screening tool for detecting UVW, but is not adequate for predicting noncaloric VNG results. C1 [Bush, Matthew L.; Bingcang, Christopher M.; Chang, Edward T.; Fomwalt, Brandon; Rayle, Christopher; Gal, Thomas J.; Jones, Raleigh O.; Shinn, Jennifer B.] Univ Kentucky, Med Ctr, Dept Otolaryngol Head & Neck Surg, Lexington, KY 40536 USA. RP Bush, ML (reprint author), Univ Kentucky, Med Ctr, Dept Otolaryngol Head & Neck Surg, 800 Rose St, Lexington, KY 40536 USA. CR Agrawal Y, 2009, ARCH INTERN MED, V169, P1419 Agrawal Y, 2009, ARCH INTERN MED, V169, P938, DOI 10.1001/archinternmed.2009.66 BARBER HO, 1971, ARCHIV OTOLARYNGOL, V94, P335 BECKER GD, 1979, LARYNGOSCOPE, V89, P311 BERNSTEI.L, 1965, ARCHIV OTOLARYNGOL, V81, P347 Cunha Luciana Cristina Matos, 2010, Pro Fono, V22, P67, DOI 10.1590/S0104-56872010000100013 DAYAL VS, 1973, LARYNGOSCOPE, V83, P1433, DOI 10.1288/00005537-197309000-00005 HART CWJ, 1965, LARYNGOSCOPE, V75, P302 JACOBSON GP, 1995, ANN OTO RHINOL LARYN, V104, P942 Jacobson GP, 1993, HDB BALANCE FUNCTION, P156 JACOBSON GP, 1985, ANN OTO RHINOL LARYN, V94, P377 JONGKEES L B, 1962, Pract Otorhinolaryngol (Basel), V24, P65 KEITH RW, 1991, OTOLARYNG HEAD NECK, V104, P499 Lightfoot G, 2009, EAR HEARING, V30, P54, DOI 10.1097/AUD.0b013e31818f006c LONGRIDGE NS, 1980, J OTOLARYNGOL, V9, P478 Murnane OD, 2009, EAR HEARING, V30, P313, DOI 10.1097/AUD.0b013e31819c3ec7 Shupak A, 2010, AVIAT SPACE ENVIR MD, V81, P369, DOI 10.3357/ASEM.2651.2010 NR 17 TC 0 Z9 0 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD JUN PY 2013 VL 122 IS 6 BP 412 EP 416 PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA 164SP UT WOS:000320430100011 PM 23837395 ER PT J AU Todd, JT Stuart, A Lintzenich, CR Wallin, J Grace-Martin, K Butler, SG AF Todd, J. Tee Stuart, Andrew Lintzenich, Catherine R. Wallin, Jordan Grace-Martin, Karen Butler, Susan G. TI Stability of Aspiration Status in Healthy Adults SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE aspiration; FEES; flexible endoscopic evaluation of swallowing; penetration; pneumonia ID FIBEROPTIC ENDOSCOPIC EVALUATION; OLDER-ADULTS; SWALLOWING FUNCTION; ACUTE STROKE; NATURAL-HISTORY; DYSPHAGIA; PENETRATION; COMPLICATIONS; PNEUMONIA; SCALE AB Objectives: In multiple separate studies, we consistently found that approximately 30% of asymptomatic healthy older adults silently aspirated liquids during flexible endoscopic evaluation of swallowing (FEES). We subsequently questioned whether aspiration status remained stable in healthy older adults over time. The purpose of this study was to deter:mine the stability of aspiration status in healthy older adults over time. Methods: Eighteen healthy older participants, comprising of 9 aspirators and 9 nonaspirators whose aspiration status was identified in a previous study, underwent a second FEES approximately 6 to 21 months later. The participants contributed 36 swallows, comprising 5-, 10-, 15-, and 20-mL boluses of milk (ie, 1 bolus of each volume of skim, 2%, whole, and soy milk) and water via cup and straw delivery, during the original FEES. An abbreviated protocol was administered for the repeat FEES. The Penetration-Aspiration Scale was used to rate all swallows. Results: A McNemar test demonstrated no change in aspiration status among participants between the initial test and the retest (p > 0.999). Conclusions: In this cohort, the aspiration status was stable over about 12 months. This finding lends credence to the premise that trace aspiration of liquids may be a normal and consistent finding in some healthy older adults. C1 [Todd, J. Tee; Lintzenich, Catherine R.; Wallin, Jordan; Butler, Susan G.] Wake Forest Sch Med, Dept Otolaryngol, Winston Salem, NC USA. [Stuart, Andrew] E Carolina Univ, Dept Commun Sci & Disorders, Greenville, NC USA. [Grace-Martin, Karen] Anal Factor, Brooktondale, NY USA. RP Butler, SG (reprint author), Dept Otolaryngol, 4th Floor,Watlington Hall,Med Ctr Blvd, Winston Salem, NC 27157 USA. FU Wake Forest University Health Sciences; NIDCD [R03 DC009875]; Wake Forest School of Medicine Claude D. Pepper Older Americans Independence Center [P30 AG21332]; GCRC grant of Wake Forest University Baptist Medical Center [M01-RR07122] FX We thank Karen Potvin Klein, MA, ELS (Research Support Core, Wake Forest University Health Sciences), for her editorial contributions.From the Department of Otolaryngology, Wake Forest School of Medicine, Winston-Salem (Todd, Lintzenich, Wallin, Butler), and the Department of Communication Sciences and Disorders, East Carolina University, Greenville (Stuart), North Carolina, and The Analysis Factor, Brooktondale, New York (Grace-Martin). This work was funded by NIDCD R03 DC009875, Wake Forest School of Medicine Claude D. Pepper Older Americans Independence Center (P30 AG21332), and the GCRC grant of Wake Forest University Baptist Medical Center (M01-RR07122). CR Allen JE, 2010, OTOLARYNG HEAD NECK, V142, P208, DOI 10.1016/j.otohns.2009.11.008 Bastian RW, 1999, LARYNGOSCOPE, V109, P1974, DOI 10.1097/00005537-199912000-00014 Butler SG, 2010, LARYNGOSCOPE, V120, P2147, DOI 10.1002/lary.21116 Butler SG, 2009, ANN OTO RHINOL LARYN, V118, P190 Butler SG, 2009, ANN OTO RHINOL LARYN, V118, P99 Butler SG, 2011, ANN OTO RHINOL LARYN, V120, P288 Chua KSG, 1996, ARCH PHYS MED REHAB, V77, P194, DOI 10.1016/S0003-9993(96)90167-7 Colodny N, 2002, DYSPHAGIA, V17, P308, DOI 10.1007/s00455-002-0073-0 Daggett A, 2006, DYSPHAGIA, V21, P270, DOI 10.1007/s00455-006-9051-6 Daniels SK, 2004, J SPEECH LANG HEAR R, V47, P33, DOI 10.1044/1092-4388(2004/004) Daniels SK, 2006, J REHABIL RES DEV, V43, P347, DOI 10.1682/JRRD.2005.01.0024 Daniels SK, 2009, AM J SPEECH-LANG PAT, V18, P74, DOI 10.1044/1058-0360(2008/07-0040) DEPIPPO KL, 1994, ARCH PHYS MED REHAB, V75, P1284 Dziewas R, 2007, DYSPHAGIA, V22, P63, DOI 10.1007/s00455-006-9032-9 EKBERG O, 1991, AM J ROENTGENOL, V156, P1181 GORDON C, 1987, BRIT MED J, V295, P411 Gottlieb D, 1996, DISABIL REHABIL, V18, P529 Hind JA, 2001, ARCH PHYS MED REHAB, V82, P1661, DOI 10.1053/apmr.2001.28006 HOLAS MA, 1994, ARCH NEUROL-CHICAGO, V51, P1051 Kelly AM, 2007, LARYNGOSCOPE, V117, P1723, DOI 10.1097/MLG.0b013e318123ee6a KIDD D, 1995, QJM-MON J ASSOC PHYS, V88, P409 Langmore SE, 1998, DYSPHAGIA, V13, P69, DOI 10.1007/PL00009559 LANGMORE SE, 1991, ANN OTO RHINOL LARYN, V100, P678 Leder SB, 1998, DYSPHAGIA, V13, P19, DOI 10.1007/PL00009544 Lim SHB, 2001, DYSPHAGIA, V16, P1, DOI 10.1007/s004550000038 Mann G, 1999, STROKE, V30, P744 Martin Bonnie J. W., 1994, Dysphagia, V9, P1 Martino R, 2005, STROKE, V36, P2756, DOI 10.1161/01.STR.0000190056.76543.eb Masiero S, 2008, NEUROL SCI, V29, P139, DOI 10.1007/s10072-008-0925-2 McCullough GH, 2007, TOP GERIATR REHABIL, V23, P290 Murray J, 1996, DYSPHAGIA, V11, P99, DOI 10.1007/BF00417898 Rao N, 2003, J APPL RES, V3, P89 Robbins J, 2008, ANN INTERN MED, V148, P715 Robbins J, 1999, DYSPHAGIA, V14, P228, DOI 10.1007/PL00009610 Robbins J, 2008, ANN INTERN MED, V148, P509 Rosenbek JC, 1996, DYSPHAGIA, V11, P93, DOI 10.1007/BF00417897 Sala R, 1998, REV NEUROLOGIA, V27, P759 Smithard DG, 1996, STROKE, V27, P1200 Smithard DG, 1998, STROKE, V29, P1480 Smith-Hammond CA, 2004, SPINE, V29, P1441, DOI 10.1097/01.BRS.0000129100.59913.EA Suiter DM, 2007, OTOLARYNG HEAD NECK, V137, P956, DOI 10.1016/j.otohns.2007.09.004 Wu CH, 1997, LARYNGOSCOPE, V107, P396 Yoshikawa M, 2005, J GERONTOL A-BIOL, V60, P506 NR 43 TC 2 Z9 2 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD MAY PY 2013 VL 122 IS 5 BP 289 EP 293 PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA 147PW UT WOS:000319180500001 PM 23815044 ER PT J AU Sinclair, CF Gurey, LE Brin, MF Stewart, C Blitzer, A AF Sinclair, Catherine F. Gurey, Lowell E. Brin, Mitchell F. Stewart, Celia Blitzer, Andrew TI Surgical Management of Airway Dysfunction in Parkinson's Disease Compared With Parkinson-Plus Syndromes SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article; Proceedings Paper CT Meeting of the American-Broncho-Esophagological-Association CY APR 18-19, 2012 CL San Diego, CA SP Amer Broncho Esophagol Assoc DE airway; dysphagia; laryngology; neurolaryngology; Parkinson's disease; voice ID MULTIPLE SYSTEM ATROPHY; BREATHING DISORDERS; AUTONOMIC FAILURE; NATURAL-HISTORY; SLEEP; PD AB Objectives: We sought to compare the laryngeal symptoms of Parkinson's disease (PD) with those of multiple system atrophy (MSA), a Parkinson-plus syndrome; to review the differences in surgical management of upper airway dysfunction between patients with PD and those with MSA; and to present a treatment algorithm for management of upper airway disorders in patients with PD and MSA. Methods: We analyzed the airway manifestations of each disease, including clinical and physiological test results and management outcomes, in a case series of 30 patients (24 with PD and 6 with MSA). Results: Vocal fold atrophy causing bowing with a midfold glottic gap was common in patients with PD. One third of patients with PD underwent vocal fold augmentation with noticeable improvement in vocal volume and phonation time. Tracheostomy was required for life-threatening sleep apnea in 50% of the patients with MSA. Systemic medications and speech therapy were integral components of the management regimen. Conclusions: Surgical management of laryngeal disorders in patients with PD should focus on restoring bulk to atrophic vocal folds to minimize glottic gaps, thus improving vocalization efficiency even in the presence of impaired respiratory effort. Conversely, the autonomic dysfunction that characterizes MSA results in upper airway obstruction, and thus surgical management focuses primarily on maintaining an adequate airway, which frequently necessitates tracheostomy. C1 [Sinclair, Catherine F.; Gurey, Lowell E.; Blitzer, Andrew] St Lukes Roosevelt Hosp, New York Ctr Voice & Swallowing Disorders, New York, NY 10019 USA. [Stewart, Celia] NYU, Dept Communicat Sci & Disorders, Steinhardt Sch Culture Educ & Human Dev, New York, NY USA. [Brin, Mitchell F.] Univ Calif Irvine, Dept Neurol, Irvine, CA 92717 USA. RP Blitzer, A (reprint author), St Lukes Roosevelt Hosp, New York Ctr Voice & Swallowing Disorders, 425 West 59th St,10th Floor, New York, NY 10019 USA. CR ARONSON AE, 1968, J SPEECH HEAR DISORD, V33, P219 MARTIN JH, 1994, ANN OTO RHINOL LARYN, V103, P749 Benarroch EE, 2007, MOVEMENT DISORD, V22, P155, DOI 10.1002/mds.21236 Brin MF, 2009, NEUROLOGIC DISORDERS, P160 Fahn S., 1986, DIS NERVOUS SYSTEM C, P1217 HANSON DG, 1984, LARYNGOSCOPE, V94, P348 Harcourt J, 1996, EUR J NEUROL, V3, P186, DOI 10.1111/j.1468-1331.1996.tb00421.x LOGEMANN JA, 1978, J SPEECH HEAR DISORD, V43, P47 MANNI R, 1993, J NEUROL, V240, P247, DOI 10.1007/BF00818713 Maria B, 2003, RESP MED, V97, P1151, DOI 10.1016/S0954-6111(03)00188-4 Martens KAE, 2012, MOVEMENT DISORD, V27, P387, DOI 10.1002/mds.24042 MUNSCHAUER FE, 1990, NEUROLOGY, V40, P677 Plazzi G, 1997, NEUROLOGY, V48, P1094 Polatli M, 2001, EUR J NEUROL, V8, P341, DOI 10.1046/j.1468-1331.2001.00253.x Ramig LO, 2001, J NEUROL NEUROSUR PS, V71, P493, DOI 10.1136/jnnp.71.4.493 Schaller S, 2012, MOVEMENT DISORD, V27, P454, DOI 10.1002/mds.24897 Schrag A, 2008, MOVEMENT DISORD, V23, P294, DOI 10.1002/mds.21839 SCHULZ JB, 1994, J NEUROL NEUROSUR PS, V57, P1047, DOI 10.1136/jnnp.57.9.1047 Seccombe LM, 2011, RESP PHYSIOL NEUROBI, V179, P300, DOI 10.1016/j.resp.2011.09.012 Suderowf A, 2012, MOVEMENT DISORD, V27, P406 Vetrugno R, 2004, SLEEP MED, V5, P21, DOI 10.1016/j.sleep.2003.07.002 WENNING GK, 1994, BRAIN, V117, P835, DOI 10.1093/brain/117.4.835 NR 22 TC 0 Z9 0 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD MAY PY 2013 VL 122 IS 5 BP 294 EP 298 PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA 147PW UT WOS:000319180500002 PM 23815045 ER PT J AU Murgu, SD Colt, HG AF Murgu, Septimiu D. Colt, Henri G. TI Combined Optical Coherence Tomography and Endobronchial Ultrasonography for Laser-Assisted Treatment of Postintubation Laryngotracheal Stenosis SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE endobronchial ultrasound; laser; optical coherence tomography; tracheal stenosis ID TRACHEAL STENOSIS; AIRWAY; TISSUE; BRONCHOSCOPY; MANAGEMENT; ULTRASOUND; INJURY AB Objectives: We describe the use of combined optical coherence tomography (OCT) and endobronchial ultrasonography (EBUS) to identify the residual hypertrophic tissues and persistent inflammation that are known contributors to stricture recurrence after laser-assisted mechanical dilation (LAMD) of laryngotracheal stenosis (LTS). Methods: Commercially available high-frequency EBUS (approximately 100-mu m resolution) and time-domain OCT (approximately 10- to 20-mu m resolution) systems were used to visualize airway wall microstructures in the area of hypertrophic tissue formation before and after LAMD in 2 patients with complex circumferential postintubation LTS. Results: Before LAMD, EBUS revealed a homogeneous layer consistent with hypertrophic tissue overlying a hyperechogenic layer corresponding to tracheal cartilage. OCT revealed a homogeneous light backscattering layer and an absence of layered microstructures within hypertrophic tissue. Immediately after LAMD, OCT of the laser-charred tissue showed high backscattering and shadowing artifacts; OCT of noncharred tissue showed bright light backscattering regions that suggested acute inflammation. EBUS revealed thinner but persistent hypertrophic tissue overlying the cartilage. Stenosis recurred in both patients. Conclusions: Intraoperative use of EBUS and OCT could potentially identify residual hypertrophic tissues and persistent inflammation during or after LAMD. It might help physicians predict stricture recurrence, prompting alternative therapeutic strategies and avoidance of repeated endoscopic treatments for LTS. C1 [Murgu, Septimiu D.; Colt, Henri G.] Univ Calif Irvine, Dept Pulm & Crit Care Med, Orange, CA 92668 USA. RP Murgu, SD (reprint author), Univ Chicago, 5841 S Maryland Ave,MC 6076, Chicago, IL 60637 USA. CR BLOOM G, 1956, Acta Morphol Neerl Scand, V1, P12 Boppart SA, 1999, J SURG RES, V82, P275, DOI 10.1006/jsre.1998.5555 Cavaliere S, 2007, Monaldi Arch Chest Dis, V67, P73 Colt H, 2009, J BIOMED OPT, V14, DOI 10.1117/1.3223334 Colt H, 2009, J BIOMED OPT, V14, DOI 10.1117/1.3155524 Colt HG, 2010, LARYNGOSCOPE, V120, P468, DOI 10.1002/lary.20780 COOPER JD, 1969, ANN SURG, V169, P334, DOI 10.1097/00000658-196903000-00007 COURAUD L, 1990, EUR J CARDIO-THORAC, V4, P521, DOI 10.1016/1010-7940(90)90139-Q Galluccio G, 2009, EUROPEAN J CARDIOTHO, V35, P933 Galluccio G, 2009, EUR J CARDIO-THORAC, V35, P429, DOI 10.1016/j.ejcts.2008.10.041 GRILLO HC, 1995, J THORAC CARDIOV SUR, V109, P486, DOI 10.1016/S0022-5223(95)70279-2 Hanna N, 2005, J THORAC CARDIOV SUR, V129, P615, DOI 10.1016/j.jtcvs.2004.10.022 Hsiung PL, 2005, J BIOMED OPT, V10, DOI 10.1117/1.2147155 Iwamoto Y, 2004, CHEST, V126, P1344, DOI 10.1378/chest.126.4.1344 Jung W, 2004, LASER SURG MED, V35, P121, DOI 10.1002/lsm.20072 Kurimoto N., 2001, ENDOBRONCHIAL ULTRAS, P33 Kurimoto N, 1999, CHEST, V115, P1500, DOI 10.1378/chest.115.6.1500 Kwon OJ, 2003, EXP LUNG RES, V29, P329, DOI 10.1080/01902140390116517 Lee P, 2007, RESPIROLOGY, V12, P299, DOI 10.1111/j.1440-1843.2006.01021.x MEHTA AC, 1993, CHEST, V104, P673, DOI 10.1378/chest.104.3.673 Miyazu Y, 2003, CHEST, V124, P2393, DOI 10.1378/chest.124.6.2393 Muller HH, 2012, BIOMED OPT EXPRESS, V3, P1025, DOI 10.1364/BOE.3.001025 Murgu S, 2008, RESPIROLOGY, V13, P315, DOI 10.1111/j.1440-1843.2007.01216.x Murgu S, 2009, LARYNGOSCOPE, V119, P1318, DOI 10.1002/lary.20478 Rea F, 2002, EUR J CARDIO-THORAC, V22, P352, DOI 10.1016/S1010-7940(02)00342-1 Vakoc BJ, 2007, J BIOMED OPT, V12, DOI 10.1117/1.2714027 Whiteman SC, 2006, CLIN CANCER RES, V12, P813, DOI 10.1158/1078-0432.CCR-05-0245 Yin JC, 2010, J BIOMED OPT, V15, DOI 10.1117/1.3308642 NR 28 TC 1 Z9 1 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD MAY PY 2013 VL 122 IS 5 BP 299 EP 307 PG 9 WC Otorhinolaryngology SC Otorhinolaryngology GA 147PW UT WOS:000319180500003 PM 23815046 ER PT J AU Brodsky, JR Mejico, LJ Giraud, A Woods, CI AF Brodsky, Jacob R. Mejico, Luis J. Giraud, Andrew Woods, Charles I. TI Impairment of Habituation of the Auditory Brain Stem Response in Migrainous Vertigo SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE auditory brain stem response; migraine; vertigo; vestibular migraine ID INFERIOR COLLICULUS; VESTIBULAR MIGRAINE; MANAGEMENT; SEROTONIN; DIZZINESS; DYSFUNCTION; POTENTIALS; INTENSITY; THERAPY AB Objectives: We evaluated the auditory brain stem response (ABR) in migrainous vertigo (MV). Methods: Four subjects who met clinical criteria for definite MV and 4 subjects with non-vertiginous migraine (NVM) underwent ABR testing while asymptomatic and within 16 hours of a symptomatic episode. Four control subjects were also tested. A set of 4 consecutive 750-click series was administered at 50-, 60-, and 70-dB intensities. We compared the groups in terms of habituation of the amplitude of wave IV-V (habituation of IV-V) from the first through fourth series for each set. Results: The habituation of IV-V amplitude to 50-dB stimuli was significantly less (p = 0.047) in the symptomatic MV group (5.08% +/- 22.32%) than in the symptomatic NVM group (-21.44% +/- 13.50%) or the control group (-26.06% +/- 9.76%). The habituation of IV-V amplitude to 70-dB stimuli in the MV group was significantly less (p = 0.031) during symptomatic testing (-3.43% +/- 8.89%) than during asymptomatic testing (-21.23% +/- 6.41%). Conclusions: The habituation of IV-V amplitude is reduced during MV attacks. This finding suggests impaired brain stem inhibition at the level of the inferior colliculus, which shares serotonergic connections with the dorsal raphe nucleus, an area hyperactive in migraine. C1 [Brodsky, Jacob R.; Giraud, Andrew; Woods, Charles I.] SUNY Upstate Med Univ, Dept Otolaryngol & Commun Sci, Syracuse, NY 13210 USA. [Mejico, Luis J.] SUNY Upstate Med Univ, Dept Neurol, Syracuse, NY 13210 USA. RP Brodsky, JR (reprint author), Childrens Hosp Boston, Dept Otolaryngol & Commun Enhancement, 300 Longwood Ave,LO-367, Boston, MA 02115 USA. CR Afridi SK, 2005, ARCH NEUROL-CHICAGO, V62, P1270, DOI 10.1001/archneur.62.8.1270 [Anonymous], 2004, CEPHALALGIA S1, V24, P9 Baier B, 2009, ANN NY ACAD SCI, V1164, P324, DOI 10.1111/j.1749-6632.2009.03868.x Bikhazi P, 1997, AM J OTOL, V18, P350 Bisdorff AR, 2004, B SOC SCI MED GRAND, V2, P103 Burstein R, 2000, ANN NEUROL, V47, P614, DOI 10.1002/1531-8249(200005)47:5<614::AID-ANA9>3.0.CO;2-N Celebisoy N, 2007, CEPHALALGIA, V28, P72 Furman JM, 2011, J HEADACHE PAIN, V12, P81, DOI 10.1007/s10194-010-0250-z Furman JM, 2003, CURR OPIN NEUROL, V16, P5, DOI 10.1097/01.wco.0000053582.70044.e2 Goadsby PJ, 2002, NEW ENGL J MED, V346, P257 Harno H, 2003, NEUROLOGY, V61, P1748 Holland PR, 2009, CEPHALALGIA, V29, P1, DOI 10.1111/j.1468-2982.2009.02027.x Hurley LM, 2002, HEARING RES, V168, P1, DOI 10.1016/S0378-5955(02)00365-9 Jeong SH, 2010, J NEUROL, V257, P905, DOI 10.1007/s00415-009-5435-5 Johnson GD, 1998, LARYNGOSCOPE, V108, P1, DOI 10.1097/00005537-199801001-00001 Kochar K, 2002, Electromyogr Clin Neurophysiol, V42, P175 Koo JW, 2006, CEPHALALGIA, V26, P1310, DOI 10.1111/j.1468-2982.2006.01208.x Lempert T, 2005, NEUROL CLIN, V23, P715, DOI 10.1016/j.ncl.2005.01.003 Lipton RB, 2002, NEUROLOGY, V58, P885 Marano E, 2005, HEADACHE, V45, P325, DOI 10.1111/j.1526-4610.2005.05069.x Murdin L, 2010, LARYNGOSCOPE, V120, P1632, DOI 10.1002/lary.21013 Neuhauser H, 2001, NEUROLOGY, V56, P436 Neuhauser H, 2003, NEUROLOGY, V60, P882 Neuhauser HK, 2006, NEUROLOGY, V67, P1028, DOI 10.1212/01.wnl.0000237539.09942.06 Reploeg MD, 2002, OTOL NEUROTOL, V23, P364, DOI 10.1097/00129492-200205000-00024 Sand T, 2000, CEPHALALGIA, V20, P804, DOI 10.1046/j.1468-2982.2000.00098.x Sand T, 2008, CLIN NEUROPHYSIOL, V119, P1190, DOI 10.1016/j.clinph.2008.01.007 Szczepaniak WS, 1996, HEARING RES, V97, P46 Teggi R, 2009, HEADACHE, V49, P435, DOI 10.1111/j.1526-4610.2009.01338.x von Brevern M, 2005, BRAIN, V128, P365, DOI 10.1093/brain/awh351 WEILLER C, 1995, NAT MED, V1, P658, DOI 10.1038/nm0795-658 NR 31 TC 1 Z9 2 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD MAY PY 2013 VL 122 IS 5 BP 308 EP 315 PG 8 WC Otorhinolaryngology SC Otorhinolaryngology GA 147PW UT WOS:000319180500004 PM 23815047 ER PT J AU Yamatodani, T Mizuta, K Hosokawa, K Takizawa, Y Sugiyama, K Nakanishi, H Mineta, H AF Yamatodani, Takashi Mizuta, Kunihiro Hosokawa, Kumiko Takizawa, Yoshinori Sugiyama, Kenichi Nakanishi, Hiroshi Mineta, Hiroyuki TI Congenital Middle Ear Cholesteatoma: Experience From 26 Surgical Cases SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE child; congenital cholesteatoma ID CHILDREN AB Objectives: We analyzed the clinical features and surgical techniques used in cases of childhood congenital cholesteatoma of the middle ear. Methods: We studied 26 patients (26 ears) who underwent surgery for congenital cholesteatoma between January 1998 and December 2009, focusing on the location and type of cholesteatoma, the surgical procedures involved, and the results obtained. Patients with prior otologic procedures were excluded. A 4-stage system was used to grade the cholesteatomas. Results: The frequency of posterior-quadrant involvement and open-type cholesteatomas increased in the more advanced stages. Second-look operations were performed in 60% of stage III and 75% of stage IV cases; and residual cholesteatomas were found in 20% of stage III and 75% of stage IV cases. Of the cases evaluated both before and after the operation, 100% of stage I and II cases, 86% of stage III cases, and 50% of stage IV cases showed improvement in hearing function. Conclusions: The staging system is relatively simple, while accurately reflecting clinical results. However, there are many differences between the anterior and posterior types of congenital cholesteatomas in surgical approach and postoperative progression that are not reflected in the classification systems and require further study. In addition, we reviewed the surgical procedures involved in anterior-quadrant cases, and propose a modified surgical procedure. C1 [Yamatodani, Takashi; Mizuta, Kunihiro; Hosokawa, Kumiko; Takizawa, Yoshinori; Sugiyama, Kenichi; Nakanishi, Hiroshi; Mineta, Hiroyuki] Hamamatsu Univ Sch Med, Dept Otorhinolaryngol Head & Neck Surg, Hamamatsu, Shizuoka 4312102, Japan. RP Yamatodani, T (reprint author), Dept Otorhinolaryngol Head & Neck Surg, Higashi Ku, 1-20-1 Handayama, Hamamatsu, Shizuoka 4313192, Japan. FU Japan Society for the Promotion of Science FX From the Department of Otorhinolaryngology Head and Neck Surgery, Hamamatsu University School of Medicine, Hamamatsu, Japan. This work was supported by a Grant-in-Aid for Wakate-B from the Japan Society for the Promotion of Science (to K.S.). CR AIMI K, 1983, LARYNGOSCOPE, V93, P1140 [Anonymous], 1995, OTOLARYNGOL HEAD NEC, V113, P186 COHEN D, 1987, AM J OTOL, V8, P61 Darrouzet V, 2002, OTOLARYNG HEAD NECK, V126, P34, DOI 10.1067/mhn.2002.121514 GRUNDFAST KM, 1995, ARCH OTOLARYNGOL, V121, P903 Kojima H, 2006, AM J OTOLARYNG, V27, P299, DOI 10.1016/j.amjoto.2005.11.016 Koltai PJ, 2002, ARCH OTOLARYNGOL, V128, P804 MCGILL TJ, 1991, LARYNGOSCOPE, V101, P606 MICHAELS L, 1986, J OTOLARYNGOL, V15, P169 MONSELL EM, 1995, OTOLARYNG HEAD NECK, V113, P176, DOI 10.1016/S0194-5998(95)70100-1 Nelson M, 2002, ARCH OTOLARYNGOL, V128, P810 Potsic WP, 2002, OTOLARYNG HEAD NECK, V126, P409, DOI 10.1067/mhn.2002.123446 Potsic WP, 2002, ARCH OTOLARYNGOL, V128, P1009 NR 13 TC 1 Z9 1 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD MAY PY 2013 VL 122 IS 5 BP 316 EP 321 PG 6 WC Otorhinolaryngology SC Otorhinolaryngology GA 147PW UT WOS:000319180500005 PM 23815048 ER PT J AU Deckard, N Yeh, J Soares, DJ Criddle, M Stachler, R Coticchia, J AF Deckard, Nathan Yeh, Justin Soares, Danny J. Criddle, Michael Stachler, Robert Coticchia, James TI Utility of Two-Stage Laryngotracheal Reconstruction in the Management of Subglottic Stenosis in Adults SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE adult subglottic stenosis; two-stage laryngotracheal reconstruction ID ANTERIOR CRICOID SPLIT; TRACHEAL RESECTION; CARTILAGE GRAFT; CHILDREN; ANASTOMOSIS; COMPLICATIONS; INFANTS; INTUBATION; PREVENTION; REPAIR AB Objectives: We examined a retrospective case series to evaluate the utility of two-stage laryngotracheal reconstruction (LTR) in the management of subglottic stenosis (SGS) in adults. Operative correction of SOS with LTR has been practiced successfully in the pediatric population. However, in the adult population, cricotracheal resection has been a more common alternative. Methods: We reviewed the medical records at the Wayne State University Department of Otolaryngology Head and Neck Surgery. We included all adult patients with SGS who underwent LTR and completed the recommended procedures between December 24, 2003, and October 1, 2010. Results: Twelve of the 14 patients identified were decannulated (86%). Of the 12 decannulated patients, 1 required a salvage operation, eventually achieving decannulation after cricotracheal resection. Therefore, although our overall decannulation rate was 86%, the rate with LTR alone was 79%. The majority of our patients (71%) had high-grade (grade III or IV) stenosis. Conclusions: We conclude that LTR is a viable option for adult patients with SGS. In children, LTR is a relatively safe and often-performed procedure. With use of modern techniques, it has the potential to be applicable to adults, as well. It has the added benefit of avoiding the pitfalls and complications associated with cricotracheal resection. C1 [Deckard, Nathan; Yeh, Justin; Soares, Danny J.; Criddle, Michael; Coticchia, James] Wayne State Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, Detroit, MI 48201 USA. [Stachler, Robert] Henry Ford Hosp, Dept Otolaryngol Head & Neck Surg, Detroit, MI 48202 USA. RP Coticchia, J (reprint author), Wayne State Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, 5E-UHC,4201 St Antoine, Detroit, MI 48201 USA. CR Ahn SH, 2004, ARCH OTOLARYNGOL, V130, P57, DOI 10.1001/archotol.130.1.57 Choi SS, 1999, ARCH OTOLARYNGOL, V125, P650 COTTON RT, 1991, LARYNGOSCOPE, V101, P1, DOI 10.1288/00005537-199112000-00001 COTTON RT, 1992, ARCH OTOLARYNGOL, V118, P1023 COTTON RT, 1988, ARCH OTOLARYNGOL, V114, P1300 COURAUD L, 1982, INT SURG, V67, P235 de Jong AL, 2000, ARCH OTOLARYNGOL, V126, P49 Donahue DM, 1997, J THORAC CARDIOV SUR, V114, P934, DOI 10.1016/S0022-5223(97)70007-2 DUNCAVAGE JA, 1989, ANN OTO RHINOL LARYN, V98, P581 Fayoux P, 2006, INT J PEDIATR OTORHI, V70, P717, DOI 10.1016/j.ijporl.2005.09.007 FEARON B, 1974, ANN OTO RHINOL LARYN, V83, P428 GRILLO HC, 1986, J THORAC CARDIOV SUR, V91, P322 GRILLO HC, 1979, J THORAC CARDIOV SUR, V78, P860 Jewett BS, 2000, OTOLARYNG HEAD NECK, V122, P488, DOI 10.1016/S0194-5998(00)70089-1 Koltai PJ, 2006, ARCH OTOLARYNGOL, V132, P631, DOI 10.1001/archotol.132.6.631 Laccourreye O, 1997, ARCH OTOLARYNGOL, V123, P1074 Lano CF, 1998, ANN OTO RHINOL LARYN, V107, P92 MANSOUR KA, 1994, ANN THORAC SURG, V57, P1120 MCCAFFREY TV, 1991, ANN OTO RHINOL LARYN, V100, P90 MCDONALD IH, 1965, BRIT J ANAESTH, V37, P161, DOI 10.1093/bja/37.3.161 MONNIER P, 1993, LARYNGOSCOPE, V103, P1273 MYER CM, 1994, ANN OTO RHINOL LARYN, V103, P319 Myer C M 3rd, 1995, Ear Nose Throat J, V74, P560 RETHI A, 1956, J Laryngol Otol, V70, P283, DOI 10.1017/S0022215100052920 Rhee JS, 2001, LARYNGOSCOPE, V111, P765, DOI 10.1097/00005537-200105000-00003 Rutter MJ, 2004, ARCH OTOLARYNGOL, V130, P737, DOI 10.1001/archotol.130.6.737 SEID AB, 1985, J PEDIATR SURG, V20, P388, DOI 10.1016/S0022-3468(85)80224-4 Varvares MA, 2004, ANN OTO RHINOL LARYN, V113, P212 Wolf M, 2001, LARYNGOSCOPE, V111, P622, DOI 10.1097/00005537-200104000-00012 Younis RT, 2004, ANN OTO RHINOL LARYN, V113, P367 ZALZAL GH, 1988, ANN OTO RHINOL LARYN, V97, P506 ZALZAL GH, 1988, LARYNGOSCOPE, V98, P849 ZALZAL GH, 1986, OTOLARYNG HEAD NECK, V94, P204 NR 33 TC 0 Z9 0 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD MAY PY 2013 VL 122 IS 5 BP 322 EP 329 PG 8 WC Otorhinolaryngology SC Otorhinolaryngology GA 147PW UT WOS:000319180500006 PM 23815049 ER PT J AU Willis, EB Folk, D Bent, JP AF Willis, Elena B. Folk, David Bent, John P. TI Adjunctive Procedures After Pediatric Single-Stage Laryngotracheoplasty SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article; Proceedings Paper CT Meeting of the Society-for-Ear-Nose-and-Throat-Advances-in-Children CY DEC 02-04, 2011 CL Kansas City, MO SP Soc Ear, Nose & Throat Advances Children DE airway; laryngoplasty; pediatrics; subglottis ID SLOW-RELEASE 5-FLUOROURACIL; SUBGLOTTIC STENOSIS; MITOMYCIN-C; RECONSTRUCTION; MANAGEMENT; CHILDREN; STENTS; LARYNX AB Objectives: We report the frequency and success rates of adjunctive airway procedures after pediatric single-stage laryngotracheoplasty (LTP) and review different adjunctive techniques in a prospectively enrolled and retrospectively reviewed case series. Methods: Of 31 LTP procedures performed from 2008 to 2011 at an academic tertiary care children's hospital, 10 were single-stage LTP procedures. These 10 cases were analyzed to determine the number and type, if any, of adjunctive procedures required after LTP, as well as the subglottic response and decannulation rates. Results: Of the 10 patients with single-stage LTP procedures, 6 patients required a total of 16 postoperative adjunctive airway procedures. The adjunctive procedures included granulation tissue removal with forceps or a carbon dioxide laser, stent placement, mitomycin C application, and triamcinolone acetonide injection. One patient also required tracheotomy placement and, eventually, cricotracheal resection. All 6 patients had significant improvement of subglottic and/or tracheal stenosis on their most recent endoscopic examination. With a minimum follow-up of 12 months, all 6 patients were decannulated. Conclusions: In this series, more than half of our pediatric patients who underwent single-stage LTP required 1 or more postoperative adjunctive procedures, and all had successful outcomes. C1 [Willis, Elena B.; Folk, David; Bent, John P.] Montefiore Med Ctr, Albert Einstein Coll Med, Dept Otolaryngol, Bronx, NY 10467 USA. RP Willis, EB (reprint author), Albert Einstein Dept Otolaryngol, 3400 Bainbridge Ave, Bronx, NY 10467 USA. CR Bauman NM, 1996, ANN OTO RHINOL LARYN, V105, P317 Bent JP, 2010, ANN OTO RHINOL LARYN, V119, P619 Cotton RT, 2000, OTOLARYNG CLIN N AM, V33, P111, DOI 10.1016/S0030-6665(05)70210-3 Ducic Y, 1999, LARYNGOSCOPE, V109, P1130, DOI 10.1097/00005537-199907000-00023 DUMON JF, 1990, CHEST, V97, P328, DOI 10.1378/chest.97.2.328 Edmondson NE, 2010, INT J PEDIATR OTORHI, V74, P1078, DOI 10.1016/j.ijporl.2010.05.027 Eliashar R, 1999, LARYNGOSCOPE, V109, P1594, DOI 10.1097/00005537-199910000-00009 FEARON B, 1972, ANN OTO RHINOL LARYN, V81, P508 GNANAPRAGASAM A, 1979, INT SURG, V64, P63 Gustafson LM, 2000, OTOLARYNG HEAD NECK, V123, P430, DOI 10.1067/mhn.2000.109007 Hartnick CJ, 2001, ARCH OTOLARYNGOL, V127, P1260 Ingrams DR, 2000, ANN OTO RHINOL LARYN, V109, P422 Ingrams DR, 1998, OTOLARYNG HEAD NECK, V118, P174, DOI 10.1016/S0194-5998(98)80006-5 Monnier P, 2005, EUR ARCH OTO-RHINO-L, V262, P602, DOI 10.1007/s00405-005-0948-8 MYER CM, 1994, ANN OTO RHINOL LARYN, V103, P319 Nguyen CV, 2010, ARCH OTOLARYNGOL, V136, P171, DOI 10.1001/archoto.2009.224 Prasad M, 2002, INT J PEDIATR OTORHI, V66, P155, DOI 10.1016/S0165-5876(02)00241-0 Quesnel AM, 2011, INT J PEDIAT OTORHIN Rahbar R, 2000, J VOICE, V14, P282, DOI 10.1016/S0892-1997(00)80037-5 ROTHSCHILD MA, 1995, ARCH OTOLARYNGOL, V121, P1175 Rutter MJ, 2008, CURR OPIN OTOLARYNGO, V16, P525, DOI 10.1097/MOO.0b013e3283184479 Santos D, 2010, LARYNGOSCOPE, V120, P815, DOI 10.1002/lary.20823 Saunders MW, 1999, INT J PEDIATR OTORHI, V50, P51, DOI 10.1016/S0165-5876(99)00235-9 SEID AB, 1991, ARCH OTOLARYNGOL, V117, P408 Shurgalin Max, 2008, Biomed Instrum Technol, V42, P318, DOI 10.2345/0899-8205(2008)42[318:ANMFMI]2.0.CO;2 Tsugawa C, 1997, J PEDIATR SURG, V32, P50, DOI 10.1016/S0022-3468(97)90092-0 Ward RF, 1998, INT J PEDIATR OTORHI, V44, P221, DOI 10.1016/S0165-5876(98)00061-5 NR 27 TC 1 Z9 1 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD MAY PY 2013 VL 122 IS 5 BP 330 EP 334 PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA 147PW UT WOS:000319180500007 PM 23815050 ER PT J AU Hoy, M Domer, A Plowman, EK Loch, R Belafsky, P AF Hoy, Monica Domer, Amanda Plowman, Emily K. Loch, Randall Belafsky, Peter TI Causes of Dysphagia in a Tertiary-Care Swallowing Center SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article; Proceedings Paper CT Meeting of the American-Broncho-Esophagological-Association CY APR 18-19, 2012 CL San Diego, CA SP Amer Broncho Esophagol Assoc DE cricopharyngeus muscle dysfunction; diagnosis; dysphagia; esophagoscopy; fluoroscopy; gastroesophageal reflux disease; GERD; manometry; pH testing; prevalence; radiation; reflux; stricture ID QUALITY-OF-LIFE; NECK-CANCER; PREVALENCE; HEAD; COMPLICATIONS; RADIOTHERAPY; DISEASE; REFLUX AB Objectives: Dysphagia can be caused by a myriad of disease processes, and it has significant impacts on patients' quality of life, life expectancy, and economic burden. To date, the most common causes of dysphagia in outpatient tertiary-care swallowing centers are unknown. We undertook this study to determine these prevalences. We also describe the diagnostic techniques utilized to establish the diagnosis. Methods: The electronic charts of 100 consecutive patients who presented to an outpatient tertiary-care university swallowing center between January 2010 and April 2011 were retrospectively reviewed. Information regarding patient demographics, validated symptom surveys, diagnostic workups, and ultimate diagnoses was abstracted and tabulated into a central database. Descriptive statistics were used to evaluate the association between patient symptoms and diagnoses. Results: The mean age of the entire cohort was 62 +/- 13.5 years, and 58% of the cohort was male. The most common identified causes of dysphagia were reflux (27%), postirradiation dysphagia (14%), and cricopharyngeus muscle dysfunction (11%). In 13% of cases, the cause of dysphagia was undetermined. The diagnostic tests utilized included flexible laryngoscopy (71%; 17% with endoscopic swallow evaluation), modified barium swallow study (45%), esophagoscopy (35%), barium esophagography (21%), manometry (10%), and ambulatory pH testing (2%). Conclusions: The most common causes of dysphagia in a tertiary-care swallowing center are reflux, postirradiation dysphagia, and cricopharyngeus muscle dysfunction. A precise cause for the symptom could not be identified in 13% of our cohort. Endoscopic visualization (laryngoscopy, flexible endoscopic evaluation of swallowing, and transnasal esophagoscopy) and fluoroscopic swallow studies were the investigations most often utilized. These techniques can be used to arrive at a diagnosis in 80% of cases. C1 [Hoy, Monica] Univ Calgary, Dept Otolaryngol Head & Neck Surg, Calgary, AB, Canada. [Domer, Amanda; Belafsky, Peter] Univ Calif Davis, Sch Med, Dept Otolaryngol Head & Neck Surg, Sacramento, CA 95817 USA. [Loch, Randall] Loma Linda Univ, Sch Med, Loma Linda, CA USA. [Plowman, Emily K.] Univ S Florida, Dept Commun Sci & Disorders, Tampa, FL USA. RP Belafsky, P (reprint author), Univ Calif Davis, Sch Med, Dept Otolaryngol Head & Neck Surg, Ctr Voice & Swallowing, 2521 Stockton Blvd,Suite 7200, Sacramento, CA 95817 USA. CR Belafsky PC, 2008, ANN OTO RHINOL LARYN, V117, P919 Belafsky PC, 2010, EFFECTS DIAGNOSIS MA, P89 Cook IJ, 1999, GASTROENTEROLOGY, V116, P455, DOI 10.1016/S0016-5085(99)70144-7 DeVault KR, 2005, AM J GASTROENTEROL, V100, P190, DOI 10.1111/j.1572-0241.2005.41217.x Groher ME, 1986, DYSPHAGIA, V1, P3, DOI 10.1007/BF02408233 Hudson HM, 2000, DYSPHAGIA, V15, P31 Koufman JA, 2002, OTOLARYNG HEAD NECK, V127, P32, DOI 10.1067/mhn.2002.125760 Maurer J, 2011, STRAHLENTHER ONKOL, V187, P744, DOI 10.1007/s00066-011-2275-x Mortensen HR, 2012, RADIOTHER ONCOL, V103, P69, DOI 10.1016/j.radonc.2012.01.002 Nguyen NP, 2005, INT J RADIAT ONCOL, V61, P772, DOI 10.1016/j.ijrobp.2004.06.017 Ott DJ, 1995, ESOPHAGUS, P41 Paterson WG, 1996, CAN FAM PHYSICIAN, V42, P925 Peponi E, 2011, RADIAT ONCOL, V6, DOI 10.1186/1748-717X-6-1 Plowman-Prine EK, 2009, MOVEMENT DISORD, V24, P1352, DOI 10.1002/mds.22617 Roy N, 2007, ANN OTO RHINOL LARYN, V116, P858 SITZMANN JV, 1990, JPEN-PARENTER ENTER, V14, P60, DOI 10.1177/014860719001400160 Smithard DG, 1996, STROKE, V27, P1200 Smithard DG, 1998, STROKE, V29, P1480 Vakil NB, 2004, CLIN GASTROENTEROL H, V2, P665, DOI 10.1053/S1542-3565(04)00289-7 Wilkins T, 2007, J AM BOARD FAM MED, V20, P144, DOI 10.3122/jabfm.2007.02.060045 NR 20 TC 1 Z9 1 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD MAY PY 2013 VL 122 IS 5 BP 335 EP 338 PG 4 WC Otorhinolaryngology SC Otorhinolaryngology GA 147PW UT WOS:000319180500008 PM 23815051 ER PT J AU Choi, JH Jun, YJ Oh, JI Jung, JY Hwang, GH Kwon, SY Lee, HM Kim, TH Lee, SH Lee, SH AF Choi, Ji Ho Jun, Young Joon Oh, Jeong In Jung, Jong Yoon Hwang, Gyu Ho Kwon, Soon Young Lee, Heung Man Kim, Tae Hoon Lee, Sang Hag Lee, Seung Hoon TI Optimal Level of Continuous Positive Airway Pressure: Auto-adjusting Titration Versus Titration With a Predictive Equation SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE adult; body mass index; continuous positive airway pressure; obstructive sleep apnea syndrome; polysomnography ID OBSTRUCTIVE SLEEP-APNEA; PRACTICE PARAMETERS; THERAPY AB Objectives: The aims of the present study were twofold. We sought to compare two methods of titrating the level of continuous positive airway pressure (CPAP) - auto-adjusting titration and titration using a predictive equation with full-night manual titration used as the benchmark. We also investigated the reliability of the two methods in patients with obstructive sleep apnea syndrome (OSAS). Methods: Twenty consecutive adult patients with OSAS who had successful, full-night manual and auto-adjusting CPAP titration participated in this study. The titration pressure level was calculated with a previously developed predictive equation based on body mass index and apnea-hypopnea index. Results: The mean titration pressure levels obtained with the manual, auto-adjusting, and predictive equation methods were 9.0 +/- 3.6, 9.4 +/- 3.0, and 8.1 +/- 1.6 cm H2O, respectively. There was a significant difference in the concordance within the range of +/- 2 cm H2O (p = 0.019) between both the auto-adjusting titration and the titration using the predictive equation compared to the full-night manual titration. However, there was no significant difference in the concordance within the range of 1 cm H2O (p > 0.999). Conclusions: When compared to full-night manual titration as the standard method, auto-adjusting titration appears to be more reliable than using a predictive equation for determining the optimal CPAP level in patients with OSAS. C1 [Choi, Ji Ho; Jun, Young Joon; Oh, Jeong In; Jung, Jong Yoon; Hwang, Gyu Ho; Kwon, Soon Young; Lee, Heung Man; Kim, Tae Hoon; Lee, Sang Hag; Lee, Seung Hoon] Korea Univ, Coll Med, Dept Otorhinolaryngol Head & Neck Surg, Seoul 136705, South Korea. RP Lee, SH (reprint author), Korea Univ, Ansan Hosp, Coll Med, Dept Otorhinolaryngol Head & Neck Surg, 516 Gojan Dong, Ansan 425707, Gyeonggi Do, South Korea. EM shleeent@korea.ac.kr FU Korea Healthcare Technology R&D Project, Ministry for Health, Welfare and Family Affairs, Republic of Korea [A090084] FX From the Department of Otorhinolaryngology Head and Neck Surgery, College of Medicine, Korea University, Seoul, Korea. This study was supported by a grant from the Korea Healthcare Technology R&D Project, Ministry for Health, Welfare and Family Affairs, Republic of Korea (A090084). CR American Academy of Sleep Medicine, 2005, INT CLASS SLEEP DIS, V2nd Basoglu OK, 2012, SLEEP BREATH, V16, P1121, DOI 10.1007/s11325-011-0612-z Choi JH, 2010, CLIN EXP OTORHINOLAR, V3, P207, DOI 10.3342/ceo.2010.3.4.207 Choi JH, 2009, SLEEP BIOL RHYTHMS, V7, P181, DOI 10.1111/j.1479-8425.2009.00401.x Epstein LJ, 2009, J CLIN SLEEP MED, V5, P263 Galetke W, 2008, RESPIRATION, V75, P163, DOI 10.1159/000097767 Iber C, 2007, AASM MANUAL SCORING Kim JH, 2009, CLIN EXP OTORHINOLAR, V2, P90, DOI 10.3342/ceo.2009.2.2.90 Kushida Clete A, 2008, J Clin Sleep Med, V4, P157 Kushida CA, 2006, SLEEP, V29, P240 Morgenthaler TI, 2006, SLEEP, V29, P1031 Powell NB, 2009, CLIN EXP OTORHINOLAR, V2, P107, DOI 10.3342/ceo.2009.2.3.107 Schiza SE, 2011, SLEEP BREATH, V15, P417, DOI 10.1007/s11325-010-0352-5 So YK, 2009, CLIN EXP OTORHINOLAR, V2, P181, DOI 10.3342/ceo.2009.2.4.181 SULLIVAN CE, 1981, LANCET, V1, P862 NR 15 TC 0 Z9 0 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD MAY PY 2013 VL 122 IS 5 BP 339 EP 343 PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA 147PW UT WOS:000319180500009 PM 23815052 ER PT J AU Johnson, AW Sidman, JD Lin, JZ AF Johnson, Alan W. Sidman, James D. Lin, Jizhen TI Bioluminescent Imaging of Pneumococcal Otitis Media in Chinchillas SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE acute otitis media; antibiotics; bioluminescence; labyrinthitis ID MIDDLE-EAR FLUID; EUSTACHIAN-TUBE; STREPTOCOCCUS-PNEUMONIAE; CHILDREN; MODEL; MICRODIALYSIS; AMOXICILLIN; ANATOMY AB Objectives: Bioluminescent imaging has emerged as a powerful tool for monitoring the pathological process of infections in animals. The purpose of this study was to harness this new tool for objective assessment of acute otitis media (AOM) in animals with and without antibiotic interventions. Methods: Thirty-six healthy chinchillas, free of middle ear infections, were randomly divided into a control group and a group that received amoxicillin treatment. Bioluminescent Streptococcus pneumoniae (Xen 10) was injected into the epitympanic bullae of chinchillas (50 colony-forming units each) for induction of AOM. The infectious process of Xen 10 in the bullae of living animals with and without antibiotic interventions was monitored in real time with bioluminescence equipment. Results: A dynamic change of bioluminescent signals in the bullae of chinchillas from days 1 to 14 was observed after Xen 10 injection. Amoxicillin treatment reduced the bioluminescent signals in the bullae of chinchillas compared with controls. The AOM persisted for 14 days, and middle ear effusion for 6 weeks, in the control animals, whereas AOM lasted for 2 days, and effusion for 6 to 12 days, in the antibiotic-treated animals. Conclusions: Bioluminescent imaging provides an innovative method for assessment of the bacterial loads in the middle ear of chinchillas a real-time manner and is very useful for objective evaluation of the efficacy of therapeutic interventions. C1 [Johnson, Alan W.; Sidman, James D.; Lin, Jizhen] Univ Minnesota, Sch Med, Dept Otolaryngol Head & Neck Surg, Minneapolis, MN 55455 USA. RP Lin, JZ (reprint author), Lions Res Bldg,Room 221A,2001 6th St SE, Minneapolis, MN 55455 USA. FU 5M Lions Research Fund; National Institutes of Health [R01 DC008165, 00010055] FX From the Department of Otolaryngology Head and Neck Surgery, University of Minnesota School of Medicine, Minneapolis, Minnesota. This study was supported by the 5M Lions Research Fund and by National Institutes of Health grant R01 DC008165 and Supplement 00010055. This study was performed in accordance with the PHS Policy on Humane Care and Use of Laboratory Animals, the NM Guide for the Care and Use of Laboratory Animals, and the Animal Welfare Act (7 U.S.C. et seq.); the animal use protocol was approved by the Institutional Animal Care and Use Committee (IACUC) of the University of Minnesota. CR BAKALETZ LO, 1989, ACTA OTO-LARYNGOL, V107, P235, DOI 10.3109/00016488909127503 BLUESTONE CD, 1982, NEW ENGL J MED, V306, P1399, DOI 10.1056/NEJM198206103062305 Cantekin EI, 1996, JAMA-J AM MED ASSOC, V275, P186 Contag CH, 1995, MOL MICROBIOL, V18, P593, DOI 10.1111/j.1365-2958.1995.mmi_18040593.x Dagan R, 2000, VACCINE, V19, pS9, DOI 10.1016/S0264-410X(00)00272-3 Daly K A, 1999, Pediatr Rev, V20, P85, DOI 10.1542/pir.20-3-85 DANIEL HJ, 1982, ANN OTO RHINOL LARYN, V91, P82 Eskola J, 2001, NEW ENGL J MED, V344, P403, DOI 10.1056/NEJM200102083440602 Francis KP, 2001, INFECT IMMUN, V69, P3350, DOI 10.1128/IAI.69.5.3350-3358.2001 Freid V.M., 1998, VITAL HLTH STAT, V13, P1 Gates GA, 1996, OTOLARYNG HEAD NECK, V114, P525, DOI 10.1016/S0194-5998(96)70243-7 Giebink GS, 2001, NEW ENGL J MED, V345, P1177, DOI 10.1056/NEJMra010462 Giebink GS, 1999, MICROB DRUG RESIST, V5, P57, DOI 10.1089/mdr.1999.5.57 HANAMURE Y, 1987, AM J OTOLARYNG, V8, P127, DOI 10.1016/S0196-0709(87)80035-2 Hausdorff WP, 2002, PEDIATR INFECT DIS J, V21, P1008, DOI 10.1097/01.inf.0000035588.98856.05 Huang Y, 2007, ANTIMICROB AGENTS CH, V51, P4336, DOI 10.1128/AAC.00405-07 Huang Y, 2001, J PHARM SCI, V90, P2088, DOI 10.1002/jps.1159 JOSSART GH, 1990, PHARMACEUT RES, V7, P1242, DOI 10.1023/A:1015977603224 JUHN SK, 1991, OTOLARYNG CLIN N AM, V24, P813 Melhus A, 2003, APMIS, V111, P989, DOI 10.1034/j.1600-0463.2003.1111012.x Sadikot Ruxana T., 2008, V477, P383, DOI 10.1007/978-1-60327-517-0_29 Sato A, 2004, COMPARATIVE MED, V54, P631 Sawchuk RJ, 2005, PHARMACOTHERAPY, V25, p140S, DOI 10.1592/phco.2005.25.12part2.140S TEELE DW, 1989, J INFECT DIS, V160, P83 Zinn KR, 2008, ILAR J, V49, P103 NR 25 TC 1 Z9 1 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD MAY PY 2013 VL 122 IS 5 BP 344 EP 352 PG 9 WC Otorhinolaryngology SC Otorhinolaryngology GA 147PW UT WOS:000319180500010 PM 23815053 ER PT J AU Belafsky, PC Plowman, EK Mehdizadeh, O Cates, D Domer, A Yen, KC AF Belafsky, Peter C. Plowman, Emily K. Mehdizadeh, Omid Cates, Daniel Domer, Amanda Yen, Kaicheng TI The Upper Esophageal Sphincter Is Not Round: A Pilot Study Evaluating a Novel, Physiology-Based Approach to Upper Esophageal Sphincter Dilation SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article; Proceedings Paper CT Meeting of the American-Broncho-Esophagological-Association CY APR 18-19, 2012 CL San Diego, CA SP Amer Broncho Esophagol Assoc DE balloon; bougie; controlled radial expansion balloon; dilation; dysphagia; esophagus; stricture; UES; upper esophageal sphincter; web ID HEAD AB Objectives: Recent basic science investigations have suggested that the upper esophageal sphincter (UES), in cross section, is not round, but that it more closely approximates a kidney shape. Dilation with simultaneous use of two cylindrical dilators provides a novel, physiology-based approach to UES distention. We evaluated the initial safety and efficacy of UES dilation with simultaneous use of two controlled radial expansion balloon dilators. Methods: Using a computerized database, we reviewed the charts of all persons who underwent UES dilation with simultaneous use of two radial expansion balloon dilators between December 1, 2011, and March 15, 2012. Information regarding patient demographics, indications, technique, and complications was abstracted. Self-reported swallowing impairment was assessed with the validated 10-item Eating Assessment Tool (EAT-10). Results: Ten individuals underwent simultaneous dilation with two dilators. Their mean age was 65 years (SD, 14 years), and 7 (70%) of them were male. The indications for dilation were radiation-induced UES stenosis (50%), cricopharyngeus muscle dysfunction (30%), upper esophageal web (10%), and anastomotic stricture (10%). After the double-balloon dilation, no complications were reported. The mean EAT-10 score improved significantly, from 34.3 (SD, 13.5) to 16.7 (SD, 8.4), after the simultaneous dilation (p = 0.003). Conclusions: Pilot data suggest that simultaneous dilation of the UES with two controlled radial expansion balloon dilators is feasible, safe, and effective. Future investigation is necessary to confirm the safety of this technique in a larger cohort and to use objective measures of efficacy to compare the technique to conventional dilation with a single dilator. C1 [Belafsky, Peter C.; Mehdizadeh, Omid; Cates, Daniel; Domer, Amanda; Yen, Kaicheng] Univ Calif Davis, Ctr Voice & Swallowing, Sch Med, Dept Otolaryngol Head & Neck Surg, Sacramento, CA 95817 USA. [Plowman, Emily K.] Univ S Florida, Dept Commun Sci & Disorders, Tampa, FL USA. RP Belafsky, PC (reprint author), Univ Calif Davis, Ctr Voice & Swallowing, Sch Med, Dept Otolaryngol Head & Neck Surg, 2521 Stockton Blvd,Suite 7200, Sacramento, CA 95817 USA. CR Ahlawat SK, 2008, GASTROINTEST ENDOSC, V68, P19, DOI 10.1016/j.gie.2007.11.027 Allen JE, 2011, DYSPHAGIA, V26, P272, DOI 10.1007/s00455-010-9304-2 Belafsky PC, 2008, ANN OTO RHINOL LARYN, V117, P919 Cates D, 2013, LARYNGOSCOPE, V123, P721, DOI 10.1002/lary.23634 Farwell DG, 2010, OTOLARYNG HEAD NECK, V143, P375, DOI 10.1016/j.otohns.2010.05.006 Hernandez LV, 2010, GASTROINTEST ENDOSC, V72, P587, DOI 10.1016/j.gie.2010.04.029 Hoy M, ANN OTOL RH IN PRESS PATTERSON DJ, 1983, GASTROENTEROLOGY, V85, P346 Rees CJ, 2009, ARCH OTOLARYNGOL, V135, P781, DOI 10.1001/archoto.2009.115 NR 9 TC 0 Z9 0 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD APR PY 2013 VL 122 IS 4 BP 217 EP 221 PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA 125QD UT WOS:000317555400001 PM 23697317 ER PT J AU Sanchez-Cuadrado, I Lassaletta, L Perez-Mora, RM Zernotti, M Di Gregorio, MF Boccio, C Gavilan, J AF Sanchez-Cuadrado, Isabel Lassaletta, Luis Maria Perez-Mora, Rosa Zernotti, Mario Fernanda Di Gregorio, Maria Boccio, Carlos Gavilan, Javier TI Is There an Age Limit for Cochlear Implantation? SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE cochlear implant; elderly; presbycusis; quality of life ID QUALITY-OF-LIFE; OLDER-ADULTS; SPEECH RECOGNITION; HEARING-LOSS; BENEFIT; NOISE; POPULATION; AUDIBILITY; IMPAIRMENT; PERCEPTION AB Objectives: We evaluated the quality of life following cochlear implantation in elderly postlingually deaf adults. Methods: Data were studied concerning demographics and audiometric evaluation in postlingually deaf adults at least 60 years of age who underwent cochlear implantation in 3 institutions. The Glasgow Benefit Inventory was used to quantify the quality of life. The patients were divided into 2 groups (those less than 70 years of age and those at least 70 years of age), and the results were also compared to those of younger adult cochlear implant recipients (less than 60 years of age). Results: Eighty-one patients were included in this study. The mean age at implantation was 68 years (range, 60 to 82 years). Cochlear implantation significantly improved the patients' audiometric outcomes (pure tone average and speech perception; p<0.05). The Glasgow Benefit Inventory showed a benefit overall (+36) and on the individual subscales (+49, +20, and +1). The difference in quality of life was not significant between those less than 70 and those at least 70 years of age (p = 0.90). The results were similar to those of younger postlingually deaf implant recipients. Conclusions: Elderly cochlear implant users experience an improvement in their quality of life, with outcomes similar to those achieved in younger adults. Particular attention must be paid to the possibility of age-related conditions in the elderly that may increase the risks of surgery. C1 [Sanchez-Cuadrado, Isabel; Lassaletta, Luis; Maria Perez-Mora, Rosa; Gavilan, Javier] La Paz Univ Hosp, Idipaz Inst Hlth Res, Dept Otolaryngol Head & Neck Surg, Madrid 28046, Spain. [Zernotti, Mario; Fernanda Di Gregorio, Maria] Sanatorio Allende Clin, Dept Otolaryngol Head & Neck Surg, Cordoba, Argentina. [Boccio, Carlos] Italian Hosp, Dept Otolaryngol Head & Neck Surg, Buenos Aires, DF, Argentina. RP Sanchez-Cuadrado, I (reprint author), La Paz Univ Hosp, Paseo Castellana 261, Madrid 28046, Spain. CR American Society of Anesthesiologists, 2008, ASA PHYS STAT CLASS Anderson I, 2006, ORL J OTO-RHINO-LARY, V68, P283, DOI 10.1159/000093380 Buchman C A, 1999, Ear Nose Throat J, V78, P489 CARABELLESE C, 1993, J AM GERIATR SOC, V41, P401 Carlson ML, 2010, OTOL NEUROTOL, V31, P1343, DOI 10.1097/MAO.0b013e3181edb69d Chatelin V, 2004, OTOL NEUROTOL, V25, P298, DOI 10.1097/00129492-200405000-00017 Ching TYC, 1998, J ACOUST SOC AM, V103, P1128, DOI 10.1121/1.421224 Coelho DH, 2009, LARYNGOSCOPE, V119, P355, DOI 10.1002/lary.20067 Cohen SM, 2005, ENT-EAR NOSE THROAT, V84, P29 Cohen SM, 2005, ENT-EAR NOSE THROAT, V84, P44 Cohen Seth M, 2005, Ear Nose Throat J, V84, P29 Commission of the European Communities, 2006571 COMM COMM EU Francis HW, 2002, LARYNGOSCOPE, V112, P1482, DOI 10.1097/00005537-200208000-00028 Frisina DR, 1997, HEARING RES, V106, P95, DOI 10.1016/S0378-5955(97)00006-3 Gordon-Salant S, 2005, J REHABIL RES DEV, V42, P9, DOI 10.1682/JRRD.2005.01.0006 Humes LE, 2007, J AM ACAD AUDIOL, V18, P590, DOI 10.3766/jaaa.18.7.6 Kelsall DC, 1995, AM J OTOL, V16, P610 Krabbe PFM, 2000, INT J TECHNOL ASSESS, V16, P864, DOI 10.1017/S0266462300102132 Labadie RF, 2000, OTOLARYNG HEAD NECK, V123, P419, DOI 10.1067/mhn.2000.109759 LaForge RG, 1992, J AGING HEALTH, V4, P126, DOI 10.1177/089826439200400108 Lassaletta L, 2006, EUR ARCH OTO-RHINO-L, V263, P267, DOI 10.1007/s00405-005-0987-1 Leung J, 2005, ARCH OTOLARYNGOL, V131, P1049, DOI 10.1001/archotol.131.12.1049 Mahncke HW, 2006, PROG BRAIN RES, V157, P81, DOI 10.1016/S0079-6123(06)57006-2 Migirov L, 2010, GERONTOLOGY, V56, P123, DOI 10.1159/000235864 MULROW CD, 1990, J AM GERIATR SOC, V38, P45 Robinson K, 1996, ANN OTO RHINOL LARYN, V105, P415 Sprinzl GM, 2010, GERONTOLOGY, V56, P351, DOI 10.1159/000275062 Turrentine FE, 2006, J AM COLL SURGEONS, V203, P865, DOI 10.1016/j.jamcollsurg.2006.08.026 Vermeire K, 2005, OTOL NEUROTOL, V26, P188, DOI 10.1097/00129492-200503000-00010 WALTZMAN SB, 1993, OTOLARYNG HEAD NECK, V108, P329 Wong PCM, 2009, NEUROPSYCHOLOGIA, V47, P693, DOI 10.1016/j.neuropsychologia.2008.11.032 Wong PCM, 2010, EAR HEARING, V31, P471, DOI 10.1097/AUD.0b013e3181d709c2 NR 32 TC 1 Z9 1 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD APR PY 2013 VL 122 IS 4 BP 222 EP 228 PG 7 WC Otorhinolaryngology SC Otorhinolaryngology GA 125QD UT WOS:000317555400002 PM 23697318 ER PT J AU Agarwal, R Ionita, JA Akin, EA Sadeghi, N Taheri, MR AF Agarwal, Ritu Ionita, Justin A. Akin, Esma A. Sadeghi, Nader Taheri, M. Reza TI Prevalence of Vocal Cord Paralysis in Patients With Incidentally Discovered Enlarged Lymph Nodes Along the Expected Course of the Recurrent Laryngeal Nerve SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article; Proceedings Paper CT Meeting of the American-Society-of-Neuroradiology CY APR 21-26, 2012 CL New York, NY SP Amer Soc Neuroradiol DE lymphadenopathy; recurrent laryngeal nerve; vocal cord paralysis ID FOLD PARALYSIS; CT; LYMPHADENOPATHY; ETIOLOGY AB Objectives: We sought to determine the prevalence of vocal cord paralysis in patients with incidentally discovered lymphadenopathy along the expected course of the recurrent laryngeal nerve (RLN). Methods: We reviewed the positron-emission tomographic (PET) and computed tomographic (CT) scans of 936 consecutive patients with a variety of diagnoses. Enlarged lymph nodes (short-axis diameter of more than 1 cm) along the expected course of the RLN were identified. Patients with lymphadenopathy were evaluated for CT signs of vocal cord paralysis. The medical records of patients with lymphadenopathy were reviewed for clinical signs of vocal cord paralysis. Patients with head and neck malignancies were excluded from the study. Results: Lymphadenopathy along the course of the RLN was identified in 57 of the 936 patients studied. Fifty-three of the 57 patients (93%) were found to have a malignancy. Thirty-four enlarged nodes (60%) had FUG uptake as shown on a PET/CT scan. Twenty enlarged nodes (35%) had CT evidence of extracapsular spread. Four patients (7%) had CT evidence of vocal cord paralysis. One patient (2%) had clinical evidence of vocal cord paralysis. Conclusions: In asymptomatic patients with incidental lymphadenopathy along the course of the RLN, vocal cord paralysis is rare. C1 [Agarwal, Ritu; Ionita, Justin A.; Akin, Esma A.; Taheri, M. Reza] George Washington Univ, Dept Radiol, Washington, DC 20037 USA. [Sadeghi, Nader] George Washington Univ, Dept Otolaryngol, Washington, DC 20037 USA. RP Taheri, MR (reprint author), George Washington Univ, Dept Radiol, 900 23rd St NW, Washington, DC 20037 USA. CR Benninger MS, 1998, LARYNGOSCOPE, V108, P1346, DOI 10.1097/00005537-199809000-00016 Chin SC, 2003, AM J ROENTGENOL, V180, P1165 FURUKAWA M, 1994, ORL J OTO-RHINO-LARY, V56, P161 GLAZER HS, 1983, AM J ROENTGENOL, V141, P527 JACOBS CJM, 1987, RADIOLOGY, V164, P97 Kitamura T, 2000, J Anesth, V14, P216, DOI 10.1007/s005400070010 Kumar VA, 2006, AM J NEURORADIOL, V27, P1643 Liu AY, 2001, ACAD RADIOL, V8, P137, DOI 10.1016/S1076-6332(01)90076-5 Meral M, 2004, JPN J INFECT DIS, V57, P124 Merati AL, 2006, LARYNGOSCOPE, V116, P1539, DOI 10.1097/01.mlg.0000234937.46306.c2 Myssiorek D, 2004, OTOLARYNG CLIN N AM, V37, P25, DOI 10.1016/S0030-6665(03)00172-5 Rafay MA, 2000, ANN THORAC SURG, V70, P2142, DOI 10.1016/S0003-4975(00)01193-0 Richardson BE, 2004, OTOLARYNG CLIN N AM, V37, P45, DOI 10.1016/S0030-6665(03)00179-8 WARD PH, 1982, ANN OTO RHINOL LARYN, V91, P558 NR 14 TC 1 Z9 1 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD APR PY 2013 VL 122 IS 4 BP 229 EP 234 PG 6 WC Otorhinolaryngology SC Otorhinolaryngology GA 125QD UT WOS:000317555400003 PM 23697319 ER PT J AU Barbu, AM Burns, JA Lopez-Guerra, G Landau-Zemer, T Friedman, AD Zeitels, SM AF Barbu, Anca M. Burns, James A. Lopez-Guerra, Gerardo Landau-Zemer, Tali Friedman, Aaron D. Zeitels, Steven M. TI Salvage Endoscopic Angiolytic KTP Laser Treatment of Early Glottic Cancer After Failed Radiotherapy SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article; Proceedings Paper CT Meeting of the American-Laryngological-Rhinological-and-Otological-Society, Inc CY APR 20-21, 2012 CL San Diego, CA SP Amer Laryngolog Rhinolog & Otolog Soc, Inc DE glottic cancer; glottis; laryngeal cancer; laser; microlaryngoscopy; phonomicrosurgery; phonosurgery; radiation; vocal cord; vocal fold; voice ID CONSERVATION LARYNGEAL SURGERY; TUMOR ANGIOGENESIS; RADIATION FAILURE; CARCINOMA; MICROSURGERY; MANAGEMENT; RECURRENCE; VOICE; T1 AB Objectives: Management of early glottic cancer subsequent to failed radiotherapy is challenging, especially in balancing oncological control and function preservation. Patients frequently have been incentivized against surgical management and thus have undergone radiotherapy as initial treatment. This history compounds the difficulty of discussions about surgical management after recurrence. Typically, endoscopic salvage has less morbidity than transcervical partial laryngectomy and is clearly desirable over total laryngectomy. However, there are appropriate concerns about the efficacy of endoscopic salvage and the overarching impact on larynx preservation and survival. Given our success with endoscopic angiolytic KTP laser treatment of previously nonirradiated T1 and T2 glottic cancers, we examined our results from treating similar-sized lesions after failed radiotherapy. Methods: We performed a retrospective chart review of 20 patients from our cancer database who had undergone failed radiation therapy elsewhere for early glottic cancer and then underwent endoscopic angiolytic KTP laser treatment. Results: Analysis of the geographic tumor recurrence of the 20 patients revealed T1a NO MO cancer in 4 patients, T1b N0 M0 cancer in 1 patient, T2a N0 M0 cancer in 1 patient, and T2b N0 M0 cancer in 14 patients. After KTP laser salvage treatment, 4 patients (20%) had local recurrence (all T2b) and required subsequent total laryngectomy, and 3 of these patients (15%) ultimately died of disease. The remaining 16 patients (80%) were free of disease at least 2 years after endoscopic salvage (average follow-up, 39 months). Conclusions: Our investigation provides preliminary evidence that angiolytic KTP laser salvage treatment of early glottic cancer is an effective treatment after failed irradiation. Studies with larger cohorts and longer follow-up will be necessary to establish incontrovertible evidence of its efficacy. C1 Harvard Univ, Sch Med, Dept Surg, Boston, MA 02115 USA. [Zeitels, Steven M.] Massachusetts Gen Hosp, Ctr Laryngeal Surg & Voice Rehabil, Boston, MA 02114 USA. RP Zeitels, SM (reprint author), Massachusetts Gen Hosp, Ctr Laryngeal Surg & Voice Rehabil, 1 Bowdoin Sq, Boston, MA 02114 USA. CR Anderson R R, 1981, Lasers Surg Med, V1, P263 ANDERSON RR, 1983, SCIENCE, V220, P524, DOI 10.1126/science.6836297 Ansarin M, 2007, ARCH OTOLARYNGOL, V133, P1193, DOI 10.1001/archotol.133.12.1193 CASIANO RR, 1991, OTOLARYNG HEAD NECK, V104, P831 de Gier HHW, 2001, HEAD NECK-J SCI SPEC, V23, P177, DOI 10.1002/1097-0347(200103)23:3<177::AID-HED1015>3.0.CO;2-8 Folkman J, 1995, NEW ENGL J MED, V333, P1757 FOLKMAN J, 1985, ADV CANCER RES, V43, P175 FOLKMAN J, 1971, NEW ENGL J MED, V285, P1182 Friedman AD, 2013, ANN OTO RHINOL LARYN, V122, P151 Holsinger FC, 2006, HEAD NECK-J SCI SPEC, V28, P779, DOI 10.1002/hed.20415 Motamed M, 2006, LARYNGOSCOPE, V116, P451, DOI 10.1097/01.MLG.0000199591.92336.06 OUTZEN KE, 1995, J LARYNGOL OTOL, V109, P111 Piazza C, 2007, ARCH OTOLARYNGOL, V133, P1037, DOI 10.1001/archotol.133.10.1037 Puxeddu R, 2004, OTOLARYNG HEAD NECK, V130, P84, DOI 10.1016/j.otohns.2003.07.002 Quer M, 2000, HEAD NECK-J SCI SPEC, V22, P520, DOI 10.1002/1097-0347(200008)22:5<520::AID-HED13>3.0.CO;2-K Roedel RMW, 2010, AURIS NASUS LARYNX, V37, P474, DOI 10.1016/j.anl.2009.11.004 Steiner W, 2004, HEAD NECK-J SCI SPEC, V26, P477, DOI 10.1002/hed.20009 VIANI L, 1991, CANCER, V67, P577, DOI 10.1002/1097-0142(19910201)67:3<577::AID-CNCR2820670309>3.0.CO;2-W Zeitels SM, 2008, ANN OTO RHINOL LARYN, V117, P3 Zeitels SM, 2006, ANN OTO RHINOL LARYN, V115, P535 Zeitels SM, 2002, ANN OTO RHINOL LARYN, V111, P3 Zeitels Steven M, 2007, Curr Opin Otolaryngol Head Neck Surg, V15, P141, DOI 10.1097/MOO.0b013e3281574582 Zeitels SM, 2001, LARYNGOSCOPE, V111, P1862, DOI 10.1097/00005537-200110000-00036 Zeitels SM, 2006, ANN OTO RHINOL LARYN, V115, P679 NR 24 TC 1 Z9 1 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD APR PY 2013 VL 122 IS 4 BP 235 EP 239 PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA 125QD UT WOS:000317555400004 PM 23697320 ER PT J AU Ren, J Deng, YQ Xiao, BK Wang, GR Tao, ZZ AF Ren, Jie Deng, Yuqin Xiao, Bokui Wang, Guirong Tao, Zezhang TI Protective Effects of Exogenous Surfactant Protein A in Allergic Rhinitis: A Mouse Model SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE allergic rhinitis; exogenous surfactant protein A; pulmonary surfactant protein A ID GENE-EXPRESSION; ASPERGILLUS-FUMIGATUS; AIRWAY INFLAMMATION; MURINE MODEL; MICE; ASTHMA; CELLS; MONOLAYERS; ANTIGENS; DISEASES AB Objectives: A mouse model of allergic rhinitis (AR) was prepared, and exogenous surfactant protein A (SP-A) was given by an intranasal route to study its mechanism and effects in the mice. Methods: Sixty male BALB/c mice were randomly divided into a normal control group, a group with AR (AR group), and a group with AR that was given SP-A (treatment group). Results: A mouse model of AR was successfully established. Enzyme-linked immunoassay showed that the level of ovalbumin-specific immunoglobulin E in the AR group was significantly higher than those in the treatment and control groups (p < 0.05), whereas the levels were not significantly different (p > 0.05) between the treatment and control groups. Hematoxylin-eosin staining showed typical allergic injury of the nasal epithelium in the AR group, and the number of eosinophils that migrated into the nasal tissue in the AR group was significantly greater than those measured in the treatment and control groups (p < 0.05). Western blotting and real-time quantitative polymerase chain reaction testing revealed that the type 2 helper (Th2) cytokine (interleukin 4 and interleukin 5) levels were highest in the AR group, followed by the treatment and control groups, with significant differences between each of the groups (p < 0.05). Significant differences were found in the levels of nasal mucosa type 1 helper (Th1) cytokines (interferon gamma, interleukin 12) among the AR, treatment, and control groups; the highest levels were found in the control group, and the lowest levels were detected in the AR group (p < 0.05). Conclusions: Exogenous SP-A had a significant therapeutic effect in mice with AR, and its mechanisms of action included inhibition of the differentiation of Th2 cells in the nasal mucosa, reduced levels of Th2 cytokines, and increased levels of Th1 cytokines. Together, these effects corrected the Th1/Th2 imbalance, inhibited the increase of specific immunoglobulin E production, effectively reduced the symptoms of AR, and inhibited the development of AR. C1 [Ren, Jie; Deng, Yuqin; Xiao, Bokui; Tao, Zezhang] Wuhan Univ, Renmin Hosp, Clin Coll 1, Dept Otolaryngol Head & Neck Surg, Wuhan 430060, Peoples R China. [Wang, Guirong] SUNY Upstate Med Univ, Dept Surg, Syracuse, NY 13210 USA. RP Tao, ZZ (reprint author), Wuhan Univ, Renmin Hosp, Clin Coll 1, Dept Otolaryngol Head & Neck Surg, Wuhan 430060, Peoples R China. FU National Natural Science Foundation of China [201130202020008, 201130202020009]; Fundamental Research Funds for the Central Universities FX This work was supported by grants 201130202020008 and 201130202020009 from the National Natural Science Foundation of China and by Fundamental Research Funds for the Central Universities. CR Ansel KM, 2006, ANNU REV IMMUNOL, V24, P607, DOI 10.1146/annurev.immunol.23.021704.115821 Brozek JL, 2008, ALLERGY, V63, P38, DOI 10.1111/j.1398-9995.2007.01560.x Finotto S, 2002, SCIENCE, V295, P336, DOI 10.1126/science.1065544 Goss KL, 1998, AM J RESP CELL MOL, V19, P613 Kay AB, 2001, NEW ENGL J MED, V344, P30 Li XL, 2012, MOLECULES, V17, P716, DOI 10.3390/molecules17010716 Livak KJ, 2001, METHODS, V25, P402, DOI 10.1006/meth.2001.1262 Madan T, 2001, INFECT IMMUN, V69, P2728, DOI 10.1128/IAI.69.4.2728-2731.2001 Madan T, 2005, J IMMUNOL, V174, P6943 Madan T, 2001, J CLIN INVEST, V107, P467, DOI 10.1172/JCI10124 MARSHALL JD, 1995, J IMMUNOL, V155, P111 Medeiros KCP, 2009, INT IMMUNOPHARMACOL, V9, P1540, DOI 10.1016/j.intimp.2009.09.005 Morinobu A, 1998, Rinsho Byori, V46, P908 Ramanathan M, 2008, AM J RHINOL, V22, P115, DOI 10.2500/ajr.2008.22.3136 Ridsdale RA, 2001, J MEMBRANE BIOL, V180, P21, DOI 10.1007/s002320010055 Roca L, 2007, IMMUNOL CELL BIOL, V85, P610, DOI 10.1038/sj.icb.7100108 Saito H, 2001, IMMUNOLOGY, V104, P226, DOI 10.1046/j.1365-2567.2001.01253.x Schmiedl A, 2009, INT ARCH ALLERGY IMM, V148, P118, DOI 10.1159/000155742 Singh M, 2003, IMMUNOL LETT, V86, P299, DOI 10.1016/S0165-2478(03)00033-6 Sinigaglia F, 1999, DEV COMP IMMUNOL, V23, P657, DOI 10.1016/S0145-305X(99)00039-7 Takahashi H, 2006, CURR PHARM DESIGN, V12, P589, DOI 10.2174/138161206775474387 Wang GR, 2007, BBA-BIOMEMBRANES, V1768, P2060, DOI 10.1016/j.bbamem.2007.06.025 Wang JY, 1998, AM J RESP CRIT CARE, V158, P510 Woodworth BA, 2006, AM J RHINOL, V20, P461, DOI 10.2500/ajr.2006.20.2892 Woodworth BA, 2007, OTOLARYNG HEAD NECK, V137, P34, DOI 10.1016/j.otohns.2007.01.025 Wootten CT, 2006, ARCH OTOLARYNGOL, V132, P1001, DOI 10.1001/archotol.132.9.1001 Yamamoto K, 2005, CLIN EXP IMMUNOL, V142, P268, DOI 10.1111/j.1365-2249.2005.02922.x NR 27 TC 3 Z9 3 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD APR PY 2013 VL 122 IS 4 BP 240 EP 246 PG 7 WC Otorhinolaryngology SC Otorhinolaryngology GA 125QD UT WOS:000317555400005 PM 23697321 ER PT J AU Adam, SI Paskhover, B Sasaki, CT AF Adam, Stewart I. Paskhover, Boris Sasaki, Clarence T. TI Revision Zenker Diverticulum: Laser Versus Stapler Outcomes Following Initial Endoscopic Failure SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article; Proceedings Paper CT Meeting of the American-Broncho-Esophagological-Association CY APR 18-19, 2012 CL San Diego, CA SP Amer Broncho Esophagol Assoc DE carbon dioxide laser; endoscopy; revision; stapler; Zenker diverticulum ID PHARYNGEAL POUCH; ESOPHAGODIVERTICULOSTOMY; COMPLICATIONS; CO2-LASER; REPAIR AB Objectives: We used a retrospective chart review to analyze revision endoscopic carbon dioxide (CO2) laser and staple repairs of recurrent Zenker diverticulum (ZD). Methods: The medical records of patients with recurrent ZD after primary endoscopic repair were selected. The chart data included method of repair (CO2 laser or stapler), demographics (age and sex), defect size (in centimeters), preoperative and postoperative symptoms, and complications. Patients' dysphagia was graded on a modified Functional Oral Intake Scale from 1 to 4 (1 being normal intake and 4 being severely limited intake or gastrostomy tube dependence). Regurgitation was also graded on a 1-to-4 scale (1 being no regurgitation and 4 being aspiration). Results: A total of 148 consecutive patients with ZD were treated with endoscopic repair between 2000 and 2010. Twelve of these patients had revisions after failed primary endoscopic management procedures, all done with the stapler. Eight revision surgeries were performed by CO2 laser, and 4 by stapler repair. No difference was noted in patient age or defect size (laser, 3.06-cm defects; stapler, 2.75-cm defects). The length of hospital stay and the time to oral intake for the patients who had a revision stapler procedure were significantly greater (p values of 0.029 and 0.009) than those for the patients in the primary stapler procedure group. Better postoperative regurgitation scores were noted for patients who had a CO2 laser procedure. Conclusions: Secondary endoscopic repair for ZD recurrence is an effective treatment method. Better symptom outcomes were observed with secondary CO2 laser repair than with stapler revision. Patients with revision stapling had longer hospital stays and a longer time to oral intake than did patients with primary staple repairs. C1 [Adam, Stewart I.; Paskhover, Boris; Sasaki, Clarence T.] Yale Univ, Sch Med, Dept Surg, Sect Otolaryngol Head & Neck Surg, New Haven, CT 06510 USA. RP Adam, SI (reprint author), Yale Phys Bldg,4th Floor,800 Howard Ave, New Haven, CT 06510 USA. CR Adam SI, 2012, LARYNGOSCOPE, V122, P1961, DOI 10.1002/lary.23398 Aubin A, 1936, ANN OTOLARYNGOL, V2, P167 Chang CWD, 2004, LARYNGOSCOPE, V114, P519, DOI 10.1097/00005537-200403000-00025 Chang CY, 2003, LARYNGOSCOPE, V113, P957, DOI 10.1097/00005537-200306000-00009 COLLARD JM, 1993, ANN THORAC SURG, V56, P573 Cook RD, 2000, LARYNGOSCOPE, V110, P2020, DOI 10.1097/00005537-200012000-00008 Crary MA, 2005, ARCH PHYS MED REHAB, V86, P1516, DOI 10.1016/j.apmr.2004.11.049 Feeley MA, 1999, LARYNGOSCOPE, V109, P858, DOI 10.1097/00005537-199906000-00003 Koay CB, 1998, J LARYNGOL OTOL, V112, P954 LAHEY FH, 1946, ANN SURG, V124, P617, DOI 10.1097/00000658-194610000-00002 Lippert BM, 1997, LASER SURG MED, V20, P394, DOI 10.1002/(SICI)1096-9101(1997)20:4<394::AID-LSM4>3.3.CO;2-W MARTINHIRSCH DP, 1993, J LARYNGOL OTOL, V107, P723 Miller FR, 2006, LARYNGOSCOPE, V116, P1608, DOI 10.1097/01.mlg.0000233508.06499.41 Narne S, 1999, ANN OTO RHINOL LARYN, V108, P810 Ong CC, 1999, J LARYNGOL OTOL, V113, P233 PAYNE WS, 1992, HEPATO-GASTROENTEROL, V39, P109 Peracchia A, 1998, ARCH SURG-CHICAGO, V133, P695, DOI 10.1001/archsurg.133.7.695 Scher RL, 2003, LARYNGOSCOPE, V113, P63, DOI 10.1097/00005537-200301000-00012 Smith SR, 2002, ARCH OTOLARYNGOL, V128, P141 Sydow BD, 2001, AM J ROENTGENOL, V177, P1067 VANOVERBEEK JJM, 1994, ANN OTO RHINOL LARYN, V103, P178 NR 21 TC 4 Z9 4 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD APR PY 2013 VL 122 IS 4 BP 247 EP 253 PG 7 WC Otorhinolaryngology SC Otorhinolaryngology GA 125QD UT WOS:000317555400006 PM 23697322 ER PT J AU Felippu, A Mora, R Guastini, L Peretti, G AF Felippu, Alexandre Mora, Renzo Guastini, Luca Peretti, Giorgio TI Transnasal Approach to the Orbital Apex and Cavernous Sinus SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE cavernous sinus; endoscopic transnasal approach; orbital apex ID ENDOSCOPIC APPROACH; OPTIC NEUROPATHY; SPHENOID SINUS; SURGERY; DECOMPRESSION; LESIONS AB Objectives: The aim of this study was to provide the anatomic rationale for a transnasal approach to the orbital apex and cavernous sinus, and to evaluate its applicability and efficiency. Methods: One hundred patients with lesions of the orbital apex, cavernous sinus, optic nerve, clivus, parapharyngeal space, infratemporal fossa, or pterygopalatine foss a were reviewed over a 10-year period. All patients underwent an endoscopic transnasal approach to the orbital apex and cavernous sinus. The surgical technique required a standard endoscopic sinus surgery set. The possible complications were recorded and classified as intraoperative or postoperative. Results: There were complications in 8 cases: 4 intraoperative and 4 postoperative. The intraoperative complications included rupture of the internal carotid artery in 1 patient and cerebrospinal fluid leak in 3 patients. All intraoperative complications were resolved during surgery. The postoperative complications were transitory eyelid ptosis in 2 patients (resolved in 6 months) and transitory diplopia with immediate deficit of the medial rectus muscle in 2 patients (completely resolved in 1 month). Conclusions: With the use of this technique, the surgeon can precisely identify the position of the surgical instrument without losing his or her way, thereby significantly reducing the rate of complications. C1 [Felippu, Alexandre] Felippu Inst, Sao Paulo, Brazil. [Mora, Renzo; Guastini, Luca; Peretti, Giorgio] Univ Genoa, Dept Otorhinolaryngol, I-16147 Genoa, Italy. RP Mora, R (reprint author), Univ Genoa, Dept Otorhinolaryngol, Via Dei Mille 11-9, I-16147 Genoa, Italy. CR Abuzayed B, 2010, SURG RADIOL ANAT, V32, P499, DOI 10.1007/s00276-010-0651-3 Abuzayed B, 2009, J CRANIOFAC SURG, V20, P1594, DOI 10.1097/SCS.0b013e3181b0dc23 Alfieri A, 2001, NEUROSURGERY, V49, P354, DOI 10.1097/00006123-200108000-00017 Castelnuovo P, 2006, RHINOLOGY, V44, P2 Cho JH, 2010, ANN OTO RHINOL LARYN, V119, P646 Chu Sau-Tung, 2006, J Chin Med Assoc, V69, P529 Dallan I, 2010, MINIM INVAS NEUROSUR, V53, P164, DOI 10.1055/s-0030-1263106 Felippu A, 2011, ANN OTO RHINOL LARYN, V120, P581 Fraser JF, 2009, MINIM INVAS NEUROSUR, V52, P25, DOI 10.1055/s-0028-1104567 Kassam Amin, 2005, Neurosurg Focus, V19, pE4 Kingdom TT, 2003, AM J OTOLARYNG, V24, P317, DOI 10.1016/S0196-0709(03)00062-0 Kong DS, 2011, J CLIN NEUROSCI, V18, P1541, DOI 10.1016/j.jocn.2011.02.042 Locatelli Marco, 2011, Surg Neurol Int, V2, P58, DOI 10.4103/2152-7806.80123 Murchison AP, 2009, OPHTHAL PLAST RECONS, V25, P458, DOI 10.1097/IOP.0b013e3181b80d7a Murchison AP, 2011, LARYNGOSCOPE, V121, P463, DOI 10.1002/lary.21357 Nicolai P, 2008, AM J RHINOL, V22, P308, DOI 10.2500/ajr.2008.22.3170 Pletcher SD, 2007, ARCH OTOLARYNGOL, V133, P780, DOI 10.1001/archotol.133.8.780 Roth Jonathan, 2011, Orbit, V30, P43, DOI 10.3109/01676830.2010.543004 Tschopp KP, 2008, RHINOLOGY, V46, P116 Tsirbas A, 2005, OPHTHAL PLAST RECONS, V21, P271, DOI 10.1097/01.iop.0000169254.44642.3d NR 20 TC 0 Z9 0 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD APR PY 2013 VL 122 IS 4 BP 254 EP 262 PG 9 WC Otorhinolaryngology SC Otorhinolaryngology GA 125QD UT WOS:000317555400007 PM 23697323 ER PT J AU Gavriel, H Shlamkovitch, N Kessler, A Eviatar, E AF Gavriel, Haim Shlamkovitch, Nathan Kessler, Alex Eviatar, Ephraim TI Role of Computerized Dynamic Posturography in Evaluating Sinugenic Vertigo SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE dynamic posturography; rhinosinusitis; vertigo ID TEMPOROMANDIBULAR DISORDER; CRANIOFACIAL PAIN; AURAL SYMPTOMS; BRAIN-STEM AB Objectives: Vertigo associated with rhinosinusitis has seldom been reported, and the pathophysiologic mechanism is still vague. Our aim was to evaluate sinugenic vertigo with computerized dynamic posturography (CDP) and suggest a possible pathophysiologic mechanism. Methods: We conducted a prospective study of 16 patients with a clinical and radiologic diagnosis of rhinosinusitis made between January 2007 and December 2008. All patients underwent CDP on the first 2 days after diagnosis. Patients with abnormal CDP results and/or complaints of vertigo underwent follow-up CDP when healthy. Results: Five patients complained of a new onset of vertigo. The CDP demonstrated a combined disorder in 3 of them, even though the vestibular signs were intact. On follow-up examination, all 3 patients were asymptomatic, and the follow-up CDP values were normal. Conclusions: We report a surprising 20% prevalence of sinugenic vertigo associated with abnormal results on CDP. Our results might possibly indicate that the somatosensory system of the paranasal sinuses plays a major role in the pathophysiologic mechanism of sinugenic vertigo. C1 [Gavriel, Haim; Shlamkovitch, Nathan; Kessler, Alex; Eviatar, Ephraim] Tel Aviv Univ, Sackler Fac Med, Assaf Harofeh Med Ctr, Dept Otolaryngol Head & Neck Surg, Ramat Aviv, Israel. RP Gavriel, H (reprint author), Assaf Harofeh Med Ctr, Dept Otolaryngol Head & Neck Surg, IL-70300 Zerifin, Israel. CR Allum JHJ, 1999, J VESTIBUL RES-EQUIL, V9, P223 APPAIX A, 1959, Rev Otoneuroophtalmol, V31, P438 BROOKES GB, 1980, CLIN OTOLARYNGOL, V5, P23, DOI 10.1111/j.1365-2273.1980.tb01624.x Haid T, 1981, Adv Otorhinolaryngol, V27, P190 KISSEL P, 1960, Rev Otoneuroophtalmol, V32, P170 Lam DK, 2001, J OROFAC PAIN, V15, P146 Sataloff Robert T, 2005, Ear Nose Throat J, V84, P212 Sessle BJ, 2000, CRIT REV ORAL BIOL M, V11, P57 Shore SE, 2000, J COMP NEUROL, V419, P271, DOI 10.1002/(SICI)1096-9861(20000410)419:3<271::AID-CNE1>3.0.CO;2-M TERRACOL J, 1961, CONFIN NEUROL, V21, P223 Tuz HH, 2003, AM J ORTHOD DENTOFAC, V123, P620, DOI 10.1016/S0889-5406(03)00153-7 Vass Z, 1998, NEUROSCIENCE, V84, P559, DOI 10.1016/S0306-4522(97)00503-4 Watson-Williams P, 1924, Proc R Soc Med, V17, P95 NR 13 TC 0 Z9 0 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD APR PY 2013 VL 122 IS 4 BP 263 EP 268 PG 6 WC Otorhinolaryngology SC Otorhinolaryngology GA 125QD UT WOS:000317555400008 PM 23697324 ER PT J AU Gubbels, SP Zhang, Q Lenkowski, PW Hansen, MR AF Gubbels, Samuel P. Zhang, Qi Lenkowski, Paul W. Hansen, Marlan R. TI Repair of Posterior Semicircular Canal Dehiscence From a High Jugular Bulb SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE dehiscence; jugular bulb; posterior semicircular canal; repair; surgery ID INNER-EAR; VERTIGO AB Objectives: We describe the clinical evaluation and operative management of posterior semicircular canal dehiscence caused by a high jugular bulb. Methods: We performed a retrospective case report. Results: The patient had clinical and audiometric findings consistent with semicircular canal dehiscence and imaging findings that demonstrated erosion of the posterior semicircular canal by a high jugular bulb. Resurfacing of the eroded canal provided resolution of the vestibular symptoms without damage to the inner ear. Conclusions: Dehiscence of the posterior semicircular canal can cause clinical and audiometric findings similar to those of superior semicircular canal dehiscence syndrome. Resurfacing of the area of dehiscence can successfully relieve the vestibular symptoms. In the case of dehiscence of the posterior canal from a high jugular bulb, resurfacing may offer advantages over canal plugging for definitive management. C1 [Gubbels, Samuel P.; Zhang, Qi] Univ Wisconsin, Sch Med & Publ Hlth, Dept Surg, Div Otolaryngol Head & Neck Surg, Madison, WI USA. [Gubbels, Samuel P.] Univ Wisconsin, Waisman Ctr, Madison, WI 53705 USA. [Lenkowski, Paul W.; Hansen, Marlan R.] Univ Iowa, Dept Otolaryngol Head & Neck Surg, Iowa City, IA 52242 USA. RP Gubbels, SP (reprint author), Div Otolaryngol Head & Neck Surg, 600 Highland Ave,Clin Sci Ctr K4, Madison, WI 53792 USA. FU Clinical and Translational Science Award (CTSA) program through National Center for Research Resources (NCRR) [1UL1RR025011]; Clinical and Translational Science Award (CTSA) program through National Center for Advancing Translational Sciences (NCATS) [9U54TR000021]; National Institutes of Health [P30 HD003352] FX This project was supported by the Clinical and Translational Science Award (CTSA) program, previously through the National Center for Research Resources (NCRR; grant 1UL1RR025011), and now through the National Center for Advancing Translational Sciences (NCATS; grant 9U54TR000021). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Dr Gubbels receives support from National Institutes of Health grant P30 HD003352. CR Friedmann DR, 2010, LARYNGOSCOPE, V120, P365, DOI 10.1002/lary.20699 Gopen Q, 2010, OTOL NEUROTOL, V31, P339, DOI 10.1097/MAO.0b013e3181be65a4 Krombach GA, 2003, EUR RADIOL, V13, P1444, DOI 10.1007/s00330-003-1828-5 Mikulec AA, 2006, LARYNGOSCOPE, V116, P375, DOI 10.1097/01.mlg.0000200358.93385.5c Minor LB, 1998, ARCH OTOLARYNGOL, V124, P249 WADIN K, 1986, ACTA RADIOL, V27, P315 NR 6 TC 0 Z9 0 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD APR PY 2013 VL 122 IS 4 BP 269 EP 272 PG 4 WC Otorhinolaryngology SC Otorhinolaryngology GA 125QD UT WOS:000317555400009 PM 23697325 ER PT J AU Timmermans, AJ Brandsma, D Smeele, LE Rosingh, AW van den Brekel, MWM Lohuis, PJFM AF Timmermans, A. Jacqueline Brandsma, Dieta Smeele, Ludi E. Rosingh, Andert W. van den Brekel, Michiel W. M. Lohuis, Peter J. F. M. TI Cervical Osteomyelitis After Carbon Dioxide Laser Excision of Recurrent Carcinoma of the Posterior Pharyngeal Wall SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE carbon dioxide laser excision; cervical osteomyelitis; chemoradiation; neck pain; oropharyngeal carcinoma ID SPONDYLODISCITIS; DISEASE; HEAD AB Two patients with recurrent carcinoma of the posterior pharyngeal wall, previously treated with carbon dioxide (CO2) laser excision and (chemo)radiotherapy, presented with neck pain due to cervical osteomyelitis. In one patient this led to cervical spine instability, for which a haloframe was applied. Our working hypothesis was that cervical osteomyelitis was caused by an infected wound bed induced by CO2 laser excision of the tumor in the already vascular-compromised area of the irradiated posterior pharyngeal wall. We discuss the risks of leaving a wound for secondary granulation after CO2 laser excision of the posterior pharyngeal wall and prophylactic antibiotic treatment. C1 [Timmermans, A. Jacqueline; Smeele, Ludi E.; van den Brekel, Michiel W. M.; Lohuis, Peter J. F. M.] Univ Amsterdam, Netherlands Canc Inst, Antoni van Leeuwenhoek Hosp, Dept Head & Neck Oncol & Surg, Amsterdam, Netherlands. [Brandsma, Dieta] Univ Amsterdam, Netherlands Canc Inst, Antoni van Leeuwenhoek Hosp, Dept Neurol, Amsterdam, Netherlands. [Brandsma, Dieta] Univ Amsterdam, Slotervaart Hosp, Dept Neurol, Amsterdam, Netherlands. [Rosingh, Andert W.] Univ Amsterdam, Slotervaart Hosp, Dept Med Microbiol, Amsterdam, Netherlands. [Smeele, Ludi E.] Univ Amsterdam, Acad Med Ctr, Dept Oral & Maxillofacial Surg, Amsterdam, Netherlands. [van den Brekel, Michiel W. M.] Univ Amsterdam, Acad Med Ctr, Dept Otorhinolaryngol, Amsterdam, Netherlands. [van den Brekel, Michiel W. M.] Univ Amsterdam, Inst Phonet Sci, Amsterdam, Netherlands. RP Timmermans, AJ (reprint author), Plesmanlaan 121, NL-1066 CX Amsterdam, Netherlands. CR DUNCAVAGE JA, 1986, LASER SURG MED, V6, P442, DOI 10.1002/lsm.1900060504 Kosaka Y, 2010, JPN J RADIOL, V28, P388, DOI 10.1007/s11604-010-0440-2 Ledermann HP, 2003, RADIOLOGY, V228, P506, DOI 10.1148/radiol.2282020752 Rades D, 2001, RADIOTHER ONCOL, V59, P307, DOI 10.1016/S0167-8140(00)00300-5 Russell MD, 2012, LARYNGOSCOPE, V122, P945, DOI 10.1002/lary.22484 Russell NS, 2009, RADIOTHER ONCOL, V92, P477, DOI 10.1016/j.radonc.2009.05.021 Schimmer RC, 2002, J SPINAL DISORD TECH, V15, P110 Shousha M, 2012, SPINE, V37, pE30, DOI 10.1097/BRS.0b013e31821bfdb2 Spiegelberg L, 2010, J ORAL MAXIL SURG, V68, P1732, DOI 10.1016/j.joms.2010.02.040 van der Eerden PA, 2009, ARCH FACIAL PLAST S, V11, P18, DOI 10.1001/archfacial.2008.501 NR 10 TC 0 Z9 0 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD APR PY 2013 VL 122 IS 4 BP 273 EP 276 PG 4 WC Otorhinolaryngology SC Otorhinolaryngology GA 125QD UT WOS:000317555400010 PM 23697326 ER PT J AU Walner, DL Karas, A AF Walner, David L. Karas, Anatoli TI Standardization of Reporting Post-tonsillectomy Bleeding SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE postoperative hemorrhage; tonsillectomy ID HARMONIC SCALPEL TONSILLECTOMY; CONTROLLED CLINICAL-TRIAL; COLD KNIFE TONSILLECTOMY; DISSECTION TONSILLECTOMY; COBLATION TONSILLECTOMY; PEDIATRIC TONSILLECTOMY; BIPOLAR TONSILLECTOMY; ADULT TONSILLECTOMY; FIBRIN GLUE; HEMORRHAGE AB Objectives: Postoperative bleeding is a well-recognized complication after tonsillectomy. We believe significant variation exists in how bleeding following tonsillectomy is reported and that a standardized system is needed. Our goal was to develop such a system. Methods: Relevant literature was found on Ovid Medline. Studies published from 1996 to 2009 involving post-tonsillectomy bleeding were analyzed, and data were collected on the basis of strict criteria. A standardized system for reporting post-tonsillectomy bleeding was then developed. Results: A review of the literature found variation in the reporting of post-tonsillectomy bleeding and found that categorization systems for reporting bleeding are often not used. The following standardization system is proposed. Type I is bleeding, historical or observed, that does not require any intervention or control of the bleeding (except for oral rinses or intravenous administration of fluids). Type II is bleeding that requires control with local measures under topical or local anesthesia. Type III is bleeding that requires control with local measures, suture ligation, and/or aggressive cauterization in the operating room. Type IV is bleeding that requires control that includes external carotid artery ligation or embolization. Type V is bleeding that leads to the patient's death. The postoperative day on which the bleeding occurs is also reported. Conclusions: The literature on tonsillectomy varies greatly in describing and reporting post-tonsillectomy bleeding. We propose a system to standardize the reporting of post-tonsillectomy bleeding. C1 [Walner, David L.; Karas, Anatoli] Rush Univ, Med Ctr, Dept Otolaryngol, Chicago, IL 60612 USA. RP Walner, DL (reprint author), Dept Otolaryngol, 1653 W Congress Pkwy, Chicago, IL 60609 USA. CR Ahsan F, 2007, CLIN OTOLARYNGOL, V32, P24, DOI 10.1111/j.1365-2273.2007.01381.x Alexander RJ, 2004, J LARYNGOL OTOL, V118, P937 Belloso A, 2003, LARYNGOSCOPE, V113, P2010, DOI 10.1097/00005537-200311000-00029 Cardozo AAJ, 2007, CLIN OTOLARYNGOL, V32, P366 Chang KW, 2008, OTOLARYNG HEAD NECK, V138, P153, DOI 10.1016/j.otohns.2007.11.006 Chimona T, 2008, INT J PEDIATR OTORHI, V72, P1431, DOI [10.1016/j.ijporl.2008.06.006, 10.1016/j.ijport.2008.06.006] Doshi J, 2008, J LARYNGOL OTOL, V122, P374, DOI 10.1017/S0022215107006676 Dunne AA, 2003, CLIN OTOLARYNGOL, V28, P420, DOI 10.1046/j.1365-2273.2003.00736.x Ferri E, 2007, AM J OTOLARYNG, V28, P384, DOI 10.1016/j.amjoto.2006.11.007 FOX SL, 1948, ANN OTO RHINOL LARYN, V57, P1032 GUIDA RA, 1990, LARYNGOSCOPE, V100, P491 Haddow K, 2006, J LARYNGOL OTOL, V120, P450, DOI 10.1017/S0022215106000120 Hall Daniel J, 2004, Otolaryngol Head Neck Surg, V130, P300 HANDLER SD, 1986, LARYNGOSCOPE, V96, P1243 JAMES A G, 1948, Ann West Med Surg, V2, P558 Kamal SA, 2006, EUR ARCH OTO-RHINO-L, V263, P449, DOI 10.1007/s00405-005-1022-2 Kanerva M, 2003, INT J PEDIATR OTORHI, V67, P777, DOI 10.1016/S0165-5876(03)00097-1 KANG J, 1994, INT J PEDIATR OTORHI, V28, P157, DOI 10.1016/0165-5876(94)90007-8 Karatzanis A, 2008, AM J OTOLARYNG, V29, P238, DOI 10.1016/j.amjoto.2007.08.004 Karatzias GT, 2006, OTOLARYNG HEAD NECK, V134, P975, DOI 10.1016/j.otohns.2006.03.003 Karatzias GT, 2005, ORL J OTO-RHINO-LARY, V67, P225, DOI 10.1159/000088925 Lachanas VA, 2005, LARYNGOSCOPE, V115, P1591, DOI 10.1097/01.mlg.0000172044.57285.b6 Leaper M, 2006, INT J PEDIATR OTORHI, V70, P1389, DOI 10.1016/j.ijporl.2006.02.004 Lee MSW, 2003, CLIN OTOLARYNGOL, V28, P48, DOI 10.1046/j.1365-2273.2003.00664.x Lee MSW, 2005, J LARYNGOL OTOL, V119, P894 Lee MSW, 2004, OTOLARYNG HEAD NECK, V131, P833, DOI 10.1016/j.otohns.2004.08.008 Liu JH, 2001, ARCH OTOLARYNGOL, V127, P1271 Lowe D, 2007, LARYNGOSCOPE, V117, P717, DOI 10.1097/mlg.0b013e318031f0b0 Mills N, 2004, INT J PEDIATR OTORHI, V68, P1367, DOI 10.1016/j.ijpori.2004.04.009 Mink JW, 2009, INT J PEDIATR OTORHI, V73, P1499, DOI 10.1016/j.ijporl.2009.02.022 Montague ML, 2004, EUR ARCH OTO-RHINO-L, V261, P225, DOI 10.1007/s00405-003-0649-0 Montague ML, 2007, J LARYNGOL OTOL, V121, P559, DOI 10.1017/S0022215106005160 Myers EN, 1997, OPERATIVE OTOLARYNGO, V1 Nikanne E, 2005, OTOLARYNG HEAD NECK, V132, P287, DOI 10.1016/j.otohns.2004.09.005 Noordzij JP, 2006, LARYNGOSCOPE, V116, P1303, DOI 10.1097/01.mlg.0000225944.00189.e9 O'Flyinn P, 2007, ANN ROY COLL SURG, V89, P616, DOI 10.1308/003588407X205350 O'Leary S, 2005, LARYNGOSCOPE, V115, P591, DOI 10.1097/01.mlg.0000161361.66191.60 O'Reilly BJ, 2003, J LARYNGOL OTOL, V117, P382 Prokopakis EP, 2005, INT J PEDIATR OTORHI, V69, P1183, DOI 10.1016/j.ijporl.2005.03.042 Reichel O, 2007, EUR ARCH OTO-RHINO-L, V264, P277, DOI 10.1007/s00405-006-0162-3 RICHMOND KH, 1987, INT J PEDIATR OTORHI, V13, P117, DOI 10.1016/0165-5876(87)90088-7 Segal N, 2008, INT J PEDIATR OTORHI, V72, P469, DOI 10.1016/j.ijporl.2007.12.011 Shah Shahid A, 2004, J Ayub Med Coll Abbottabad, V16, P38 Stephens JC, 2008, J LARYNGOL OTOL, V122, P383, DOI 10.1017/S0022215107007311 Takwoing YM, 2007, J LARYNGOL OTOL, V121, P968, DOI 10.1017/S002221510700597X Vaiman M, 2003, ANN OTO RHINOL LARYN, V112, P410 WATSON MG, 1993, J LARYNGOL OTOL, V107, P711 Windfuhr J, 2001, J LARYNGOL OTOL, V115, P457 Windfuhr JP, 2005, ANN OTO RHINOL LARYN, V114, P749 NR 49 TC 4 Z9 4 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD APR PY 2013 VL 122 IS 4 BP 277 EP 282 PG 6 WC Otorhinolaryngology SC Otorhinolaryngology GA 125QD UT WOS:000317555400011 PM 23697327 ER PT J AU Pitman, MJ Berzofsky, C Alli, O Sharma, S AF Pitman, Michael J. Berzofsky, Craig Alli, Opeyemi Sharma, Sansar TI Recurrent Laryngeal Nerve Transection and Anastomosis: Rat Laryngeal Motoneuron Survival and Effect of the Anastomosis Site SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article; Proceedings Paper CT Meeting of the American-Broncho-Esophagological-Association CY APR 18-19, 2012 CL San Diego, CA SP Amer Broncho Esophagol Assoc DE laryngeal motoneuron; nerve reinnervation; rat model; recurrent laryngeal nerve; vocal cord paralysis; vocal fold paralysis ID GENE-TRANSFER; NUCLEUS AMBIGUUS; REINNERVATION; INJURY; INNERVATION; MODEL; ELECTROMYOGRAPHY; REGENERATION; RECOVERY; TRACERS AB Objectives: We investigated the quantity of recurrent laryngeal nerve motoneurons (RLNMs) that survive after transection and anastomosis of the rat recurrent laryngeal nerve (RLN), as well as the impact of the anastomosis site on RLN regeneration. Methods: Ten rats underwent right RLN transection and anastomosis. After 16 weeks, Fluoro-Ruby (FR) was applied to the RLN that was transected proximal or distal to the anastomosis site. The brain stems were harvested, and the nucleus ambiguus was evaluated for labeled RLNMs. The RLNM counts were compared to each other and to those from 3 control rats in which FR was applied to an acutely transected RLN. Results: The number of RLNMs that were stained after RLN transection, anastomosis, and regeneration was consistent with the total number of RLNMs in the nucleus ambiguus of control rats. This finding confirms that most RLNMs survived after RLN transection and anastomosis. The quantity of labeled RLNMs was statistically similar whether the FR was applied proximal or distal to the anastomosis, implying that most of the viable axons that were present proximal to the anastomosis crossed into the distal nerve. Conclusions: Rat RLNMs survive nerve transection, anastomosis, and regeneration. The anastomosis site does not significantly impede axonal regeneration, and most of the axons traverse the anastomosis into the distal nerve. C1 [Pitman, Michael J.; Berzofsky, Craig] New York Eye & Ear Infirm, Dept Otolaryngol, Voice & Swallowing Inst, New York, NY 10003 USA. [Alli, Opeyemi; Sharma, Sansar] New York Med Coll, Dept Cell Biol, Valhalla, NY 10595 USA. RP Pitman, MJ (reprint author), New York Eye & Ear Infirm, 310 E 14th St,6th Floor, New York, NY 10003 USA. CR Aldskogius Hakan, 1993, V2, P191 Choi D, 2002, J NEUROSCI METH, V117, P167, DOI 10.1016/S0165-0270(02)00098-5 Crumley RL, 2000, ANN OTO RHINOL LARYN, V109, P365 FISCHER H, 1979, LARYNG RHINOL OTOL V, V58, P154 FLINT PW, 1991, ANN OTO RHINOL LARYN, V100, P797 Fu SY, 1997, MOL NEUROBIOL, V14, P67, DOI 10.1007/BF02740621 HINRICHSEN CFL, 1981, EXP NEUROL, V74, P341, DOI 10.1016/0014-4886(81)90174-6 Hydman J, 2008, MUSCLE NERVE, V38, P1280, DOI 10.1002/mus.21124 Hydman J, 2005, LARYNGOSCOPE, V115, P619, DOI 10.1097/01.mlg.0000161362.43320.b2 Mori Y, 2007, LARYNGOSCOPE, V117, P1313, DOI 10.1097/MLG.0b013e31805f681f Moro K, 2006, BRAIN RES, V1076, P1, DOI 10.1021/j.brainres.2005.12.119 NAHM I, 1990, AM J OTOLARYNG, V11, P90, DOI 10.1016/0196-0709(90)90005-G Old MO, 2011, ANN OTO RHINOL LARYN, V120, P331 Pascual-Font A, 2006, Acta Otorrinolaringol Esp, V57, P253 Pascual-Font Arán, 2008, Acta Otorrinolaringol Esp, V59, P163 Pitman MJ, 2011, LARYNGOSCOPE, V121, P320, DOI 10.1002/lary.21290 PORTILLO F, 1988, BRAIN BEHAV EVOLUT, V32, P220, DOI 10.1159/000116549 Saito K, 2003, BRAIN RES, V962, P61, DOI 10.1016/S0006-8993(02)03933-1 SANDERS I, 1993, ARCH OTOLARYNGOL, V119, P934 Shiotani A, 1999, ARCH OTOLARYNGOL, V125, P555 Shiotani A, 1998, HUM GENE THER, V9, P2039, DOI 10.1089/hum.1998.9.14-2039 Statham MM, 2010, LARYNGOSCOPE, V120, P285, DOI 10.1002/lary.20629 Tessema B, 2009, LARYNGOSCOPE, V119, P1644, DOI 10.1002/lary.20293 Tessema B, 2008, ANN OTO RHINOL LARYN, V117, P604 Woodson GE, 2007, ANN OTO RHINOL LARYN, V116, P57 NR 25 TC 2 Z9 2 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD APR PY 2013 VL 122 IS 4 BP 283 EP 287 PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA 125QD UT WOS:000317555400012 PM 23697328 ER PT J AU Amin, MR Achlatis, S Lazarus, CL Branski, RC Storey, P Praminik, B Fang, YX Sodickson, DK AF Amin, Milan R. Achlatis, Stratos Lazarus, Cathy L. Branski, Ryan C. Storey, Pippa Praminik, Bidyut Fang, Yixin Sodickson, Daniel K. TI Dynamic Magnetic Resonance Imaging of the Pharynx During Deglutition SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE deglutition; dynamic magnetic resonance imaging; dysphagia; swallowing ID ULTRAFAST COMPUTERIZED-TOMOGRAPHY; RISK-FACTORS; DYSPHAGIA; PREVALENCE; IMPACT; VOLUME; MRI AB Objectives: We utilized dynamic magnetic resonance imaging to visualize the pharynx and upper esophageal segment in normal, healthy subjects. Methods: A 3-T scanner with a 4-channel head coil and a dual-channel neck coil was used to obtain high-speed magnetic resonance images of subjects who were swallowing liquids and pudding. Ninety sequential images were acquired with a temporal resolution of 113 ms. Imaging was performed in axial planes at the levels of the oropharynx and the pharyngoesophageal segment. The images were then analyzed for variables related to alterations in the area of the pharynx and pharyngoesophageal segment during swallowing, as well as temporal measures related to these structures. Results: All subjects tolerated the study protocol without complaint. Changes in the area of the pharyngeal wall lumen and temporal measurements were consistent within and between subjects. The inter-rater and intra-rater reliabilities for the measurement tool were excellent. Conclusions: Dynamic magnetic resonance imaging of the swallow sequence is both feasible and reliable and may eventually complement currently used diagnostic methods, as it adds substantive information. C1 [Amin, Milan R.; Achlatis, Stratos; Branski, Ryan C.] NYU, Voice Ctr, Dept Otolaryngol Head & Neck Surg, New York, NY 10016 USA. [Storey, Pippa; Praminik, Bidyut; Sodickson, Daniel K.] NYU, Sch Med, Ctr Biomed Imaging, Dept Radiol, New York, NY 10016 USA. [Fang, Yixin] NYU, Sch Med, Dept Biostat, New York, NY 10016 USA. [Lazarus, Cathy L.] THANC Thyroid Head & Neck Cancer Fdn, New York, NY USA. [Lazarus, Cathy L.] Beth Israel Deaconess Med Ctr, Dept Otolaryngol Head & Neck Surg, New York, NY 10003 USA. RP Amin, MR (reprint author), NYU, Voice Ctr, 345 E 37th St,Suite 306, New York, NY 10016 USA. FU Clinical and Translational Science Institute at New York University School of Medicine [NIH/NCRR 1UL1RR029893-01] FX From New York University Voice Center, Department of Otolaryngology-Head and Neck Surgery (Amin, Achlatis, Branski), the Center for Biomedical Imaging, Department of Radiology (Storey, Praminik, Sodickson), and the Department of Biostatistics (Fang), New York University School of Medicine, the THANC (Thyroid, Head and Neck Cancer) Foundation (Lazarus), and the Department of Otolaryngology-Head and Neck Surgery, Beth Israel Medical Center (Lazarus), New York, New York. This research was supported in part by the Clinical and Translational Science Institute at New York University School of Medicine (NIH/NCRR 1UL1RR029893-01). CR Altman KW, 2010, ARCH OTOLARYNGOL, V136, P784, DOI 10.1001/archoto.2010.129 Amin MR, 2012, LARYNGOSCOPE, V122, P860, DOI 10.1002/lary.22496 Aviv JE, 1998, DYSPHAGIA, V13, P87, DOI 10.1007/PL00009561 Barkhausen J, 2002, EUR RADIOL, V12, P129, DOI 10.1007/s00330-001-1146-8 CURTIS DJ, 1985, INVEST RADIOL, V20, P717, DOI 10.1097/00004424-198510000-00011 Dantas R. O., 1990, AM J PHYSIOL, V258, P675 ERGUN GA, 1993, GASTROENTEROLOGY, V105, P1396 Eslick GD, 2008, ALIMENT PHARM THERAP, V27, P971, DOI 10.1111/j.1365-2036.2008.03664.x Falsetti P, 2009, J STROKE CEREBROVASC, V18, P329, DOI 10.1016/j.jstrokecerebrovasdis.2009.01.009 Hartl DM, 2003, DYSPHAGIA, V18, P255, DOI 10.1007/s00455-003-0007-9 Isogai S, 2000, P ISMRM, P1120 Kitano H, 2002, DYSPHAGIA, V17, P187, DOI 10.1007/s00455-002-0057-4 Langmore S E, 1988, Dysphagia, V2, P216, DOI 10.1007/BF02414429 LAZARUS CL, 1993, ARCH PHYS MED REHAB, V74, P1066, DOI 10.1016/0003-9993(93)90063-G Logemann J, 1998, EVALUATION TREATMENT, V2nd Miller JL, 1997, DYSPHAGIA, V12, P125, DOI 10.1007/PL00009526 Pouderoux P, 1996, GASTROENTEROLOGY, V110, P1422, DOI 10.1053/gast.1996.v110.pm8613047 Roy N, 2007, ANN OTO RHINOL LARYN, V116, P858 Sonies B C, 1988, Dysphagia, V3, P1, DOI 10.1007/BF02406274 SUTO Y, 1995, BRIT J RADIOL, V68, P1099 Takehara I, 2004, DISABIL REHABIL, V26, P733, DOI 10.1080/09638280410001704322 Wilkins T, 2007, J AM BOARD FAM MED, V20, P144, DOI 10.3122/jabfm.2007.02.060045 NR 22 TC 3 Z9 3 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD MAR PY 2013 VL 122 IS 3 BP 145 EP 150 PG 6 WC Otorhinolaryngology SC Otorhinolaryngology GA 108OG UT WOS:000316304700001 PM 23577565 ER PT J AU Friedman, AD Hillman, RE Landau-Zemer, T Burns, JA Zeitels, SM AF Friedman, Aaron D. Hillman, Robert E. Landau-Zemer, Tali Burns, James A. Zeitels, Steven M. TI Voice Outcomes for Photoangiolytic KTP Laser Treatment of Early Glottic Cancer SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article; Proceedings Paper CT Meeting of the American-Broncho-Esophagological-Association CY APR 18-19, 2012 CL San Diego, CA SP Amer Broncho Esophagol Assoc DE glottis; laryngeal cancer; laser; microlaryngoscopy; phonomicrosurgery; phonosurgery; vocal cord; vocal fold; voice ID VOCAL FOLD INFUSION; QUALITY-OF-LIFE; FUNCTIONAL OUTCOMES; LARYNGEAL-CANCER; CARCINOMA; CO2-LASER; RADIOTHERAPY; SURGERY; MANAGEMENT; CORDECTOMY AB Objectives: Surgery and radiotherapy routinely provide high cure rates in treating early glottic cancer. Therefore, key metrics for success are optimal voice outcome and preservation of future cancer treatment options. Remarkably, there is a paucity of pretreatment versus posttreatment voice outcome data. Angiolytic KTP (potassium titanyl phosphate) laser treatment of early glottic cancer with ultranarrow margins was initiated to better preserve vocal function. Given that effective oncological results have been achieved, it was hypothesized that this approach would also result in improved posttreatment measures of vocal function that more closely approximate historical norms than pretreatment values. Methods: Pretreatment and posttreatment voice outcome data were obtained for 92 patients (64 with T1 cancer and 28 with T2 cancer) who underwent 532-nm KTP laser treatment of early glottic cancer in a study design in which each patient essentially served as his or her own control. The evaluations included objective measures (acoustic and aerodynamic) and patients' self-assessments of vocal function (Voice-Related Quality of Life; V-RQOL). A series of mixed analyses of variance were conducted for all vocal function measures, with tumor stage and depth of invasion as the between-subjects variables and time (presurgery versus postsurgery) as the within-subject variable. Results: There were statistically significant (p <= 0.05) postoperative improvements for acoustic (perturbation and noise-to-harmonics ratio) and aerodynamic (subglottic pressure and vocal efficiency) measures of vocal function, as well as for V-RQOL assessment. Conclusions: Comprehensive pretreatment and posttreatment voice measures in a large patient cohort demonstrated that the KTP laser significantly improved postoperative vocal function in patients with early glottic cancer. Furthermore, radiotherapy was preserved as an oncological treatment option. C1 Harvard Univ, Sch Med, Dept Surg, Boston, MA 02115 USA. [Zeitels, Steven M.] Massachusetts Gen Hosp, Ctr Laryngeal Surg & Voice Rehabil, Boston, MA 02114 USA. RP Zeitels, SM (reprint author), Massachusetts Gen Hosp, Ctr Laryngeal Surg & Voice Rehabil, 1 Bowdoin Sq,11th Floor, Boston, MA 02114 USA. CR Agarwal JP, 2009, RADIOTHER ONCOL, V90, P177, DOI 10.1016/j.radonc.2008.09.016 Agrawal N, 2008, OTOLARYNG CLIN N AM, V41, P757, DOI 10.1016/j.otc.2008.01.014 Barbu AM, ANN OTOL RH IN PRESS Burns JA, 2012, ANN OTO RHINOL LARYN, V121, P224 Burns JA, 2004, LARYNGOSCOPE, V114, P1864, DOI 10.1097/00005537-200410000-00035 Burns JA, 2008, LARYNGOSCOPE, V118, P1109, DOI 10.1097/MLG.0b013e31816902bb Colden Darryl, 2001, Annals of Otology Rhinology and Laryngology, V110, P293 CRAGLE SP, 1993, OTOLARYNG HEAD NECK, V108, P648 Fraenkel B, 1886, ARCH KLIN CHIR, V12, P283 Higgins KM, 2009, J OTOLARYNGOL-HEAD N, V38, P603, DOI 10.2310/7070.2009.080235 Hirano M., 1975, OTOLOGIA FUKUOKA S1, V21, P239 HIRANO M, 1988, ACTA OTO-LARYNGOL, P154 Hogikyan ND, 1999, J VOICE, V13, P557, DOI 10.1016/S0892-1997(99)80010-1 Jako G J, 1978, Int Adv Surg Oncol, V1, P265 Kass ES, 1996, ANN OTO RHINOL LARYN, V105, P341 Ledda GP, 2006, LARYNGOSCOPE, V116, P1007, DOI 10.1097/01.MLG.0000217557.45491.BD LEHMAN JJ, 1988, OTOLARYNG HEAD NECK, V98, P121 Lester SE, 2011, J LARYNGOL OTOL, V125, P1251, DOI 10.1017/S0022215111002490 Lynch RC, 1920, T AM LARYNGOL ASS, V40, P119 Mehta DD, 2008, CURR OPIN OTOLARYNGO, V16, P211, DOI 10.1097/MOO.0b013e3282fe96ce Motta S, 2008, J LARYNGOL OTOL, V122, P948, DOI 10.1017/S0022215107001211 Peretti G, 2003, ANN OTO RHINOL LARYN, V112, P174 Peretti G, 2003, ANN OTO RHINOL LARYN, V112, P759 Roh JL, 2007, HEAD NECK-J SCI SPEC, V29, P1010, DOI 10.1002/hed.20625 STRONG MS, 1972, ANN OTO RHINOL LARYN, V81, P791 STRONG MS, 1975, LARYNGOSCOPE, V85, P1286, DOI 10.1288/00005537-197508000-00003 Thomas L, 2012, CANCER TREAT REV, V38, P203, DOI 10.1016/j.ctrv.2011.05.010 van Gogh CDL, 2012, EUR ARCH OTO-RHINO-L, V269, P1647, DOI 10.1007/s00405-012-1947-1 van Loon Y, 2012, HEAD NECK-J SCI SPEC, V34, P1179, DOI 10.1002/hed.21783 VAUGHAN CW, 1978, AM J SURG, V136, P490, DOI 10.1016/0002-9610(78)90267-2 Zeitels SM, 2001, ATLAS PHONOMICROSURG, P177 Zeitels SM, 2008, ANN OTO RHINOL LARYN, V117, P3 Zeitels SM, 1996, AM J SURG, V172, P704, DOI 10.1016/S0002-9610(96)00295-4 Zeitels SM, 2004, ANN OTO RHINOL LARYN, V113, P265 Zeitels SM, 2002, ANN OTO RHINOL LARYN, V111, P3 Zeitels SM., 1993, OPERATIVE TECHNIQUES, V4, P218 Zeitels SM, 2001, LARYNGOSCOPE, V111, P1862, DOI 10.1097/00005537-200110000-00036 Zeitels SM, 1998, ANN OTO RHINOL LARYN, V107, P2 ZEITELS SM, 1995, LARYNGOSCOPE, V105, P1, DOI 10.1288/00005537-199503001-00001 Zeitels SM, 2006, ANN OTO RHINOL LARYN, V115, P679 ZEITELS SM, 1991, OTOLARYNG HEAD NECK, V105, P478 NR 41 TC 3 Z9 3 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD MAR PY 2013 VL 122 IS 3 BP 151 EP 158 PG 8 WC Otorhinolaryngology SC Otorhinolaryngology GA 108OG UT WOS:000316304700002 PM 23577566 ER PT J AU Fukuhara, T Fujiwara, K Nomura, K Miyake, N Kitano, H AF Fukuhara, Takahiro Fujiwara, Kazunori Nomura, Kenichi Miyake, Naritomo Kitano, Hiroya TI New Method for In-Office Secondary Voice Prosthesis Insertion Under Local Anesthesia by Reverse Puncture From Esophageal Lumen SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article; Proceedings Paper CT Meeting of the American-Broncho-Esophagological-Association CY APR 18-19, 2012 CL San Diego, CA SP Amer Broncho Esophagol Assoc DE in-office tracheoesophageal puncture; local anesthesia; transnasal endoscopy; voice prosthesis ID TRACHEOESOPHAGEAL PUNCTURE; TRANSNASAL ESOPHAGOSCOPY; TOTAL LARYNGECTOMY; COMPLICATIONS; RESTORATION; REHABILITATION AB Objectives: We clarify and demonstrate the utility of our new method of voice prosthesis insertion using puncture from the esophageal lumen. Methods: Our new reverse puncture method using a flexible endoscope can be performed in an outpatient clinic under local anesthesia. We conducted a clinical trial with patients with head and neck cancer between April 2010 and February 2012. Our study focused on the following three points: 1) the percentage of patients for whom the procedure was successful; 2) the duration of the operation; and 3) any adverse effects. Results: The puncture was performed successfully for 21 of 22 patients (95%). The mean duration of the operation, excluding the time for local anesthesia, was only 11.6 minutes. All patients began voice rehabilitation and attained peroral intake immediately after the operation. None of the patients suffered complications from the procedures. Conclusions: Most patients were treated with our new method with ease and at low risk. The high success rate and the absence of complications demonstrate the benefits of our method. We conclude that our method can be recommended for secondary reverse tracheoesophageal puncture. C1 [Fukuhara, Takahiro; Fujiwara, Kazunori; Miyake, Naritomo; Kitano, Hiroya] Tottori Univ, Fac Med, Dept Otolaryngol Head & Neck Surg, Yonago, Tottori 683, Japan. [Nomura, Kenichi] Tottori Univ, Fac Med, Dept Clin Invest, Yonago, Tottori 683, Japan. RP Fukuhara, T (reprint author), 36-1 Nishimachi, Yonago, Tottori 6838504, Japan. CR ANDREWS JC, 1987, LARYNGOSCOPE, V97, P562 Bach KK, 2003, LARYNGOSCOPE, V113, P173, DOI 10.1097/00005537-200301000-00032 Deschler DG, 2011, LARYNGOSCOPE, V121, P1855, DOI 10.1002/lary.21910 Deschler DG, 2009, LARYNGOSCOPE, V119, P1353, DOI 10.1002/lary.20490 Desyatnikova S, 2001, ANN OTO RHINOL LARYN, V110, P613 Doctor Vishal S, 2007, Curr Opin Otolaryngol Head Neck Surg, V15, P405, DOI 10.1097/MOO.0b013e3282f151e6 Doctor VS, 2008, J LARYNGOL OTOL, V122, P303, DOI 10.1017/S0022215107000084 Duvdevani SI, 2012, HEAD NECK-J SCI SPEC, V34, P717, DOI 10.1002/hed.21807 Eerenstein SEJ, 2002, LARYNGOSCOPE, V112, P634, DOI 10.1097/00005537-200204000-00008 GROSS M, 1994, LARYNGOSCOPE, V104, P233 HILGERS FJM, 1993, EUR ARCH OTO-RHINO-L, V250, P375 LeBert B, 2009, ARCH OTOLARYNGOL, V135, P1190, DOI 10.1001/archoto.2009.166 Lichtenberger G, 2003, OTOLARYNG HEAD NECK, V128, P835, DOI 10.1016/S0194-5998(03)00453-4 Lorenz KJ, 2010, CLIN OTOLARYNGOL, V35, P61, DOI 10.1111/j.1749-4486.2009.02032.x MANIGLIA AJ, 1989, LARYNGOSCOPE, V99, P489 Morrison MP, 2012, AM J OTOLARYNG, V33, P113, DOI 10.1016/j.amjoto.2011.04.006 Ng RWM, 2005, J LARYNGOL OTOL, V119, P988 Norsuhazenah PSD, 2010, ANN ACAD MED SINGAP, V39, P565 OSSOFF RH, 1984, OTOLARYNG HEAD NECK, V92, P418 Padhya TA, 2008, LARYNGOSCOPE, V118, P266, DOI 10.1097/MLG.0b013e318158e437 Pighi GP, 2009, LARYNGOSCOPE, V119, P1431, DOI 10.1002/lary.20518 Sidell D, 2010, OTOLARYNG HEAD NECK, V142, P284, DOI 10.1016/j.otohns.2009.09.030 SILVER FM, 1985, LARYNGOSCOPE, V95, P1360 SINGER MI, 1980, ANN OTO RHINOL LARYN, V89, P529 SINGER MI, 1985, OTOLARYNG CLIN N AM, V18, P605 Snelling JD, 2007, LOGOP PHONIATR VOCO, V32, P80, DOI 10.1080/14015430600712205 NR 26 TC 0 Z9 0 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD MAR PY 2013 VL 122 IS 3 BP 163 EP 168 PG 6 WC Otorhinolaryngology SC Otorhinolaryngology GA 108OG UT WOS:000316304700004 PM 23577568 ER PT J AU Eadie, TL Stepp, CE AF Eadie, Tanya L. Stepp, Cara E. TI Acoustic Correlate of Vocal Effort in Spasmodic Dysphonia SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE acoustic measure; fundamental frequency; vocal effort; voice ID RELATIVE FUNDAMENTAL-FREQUENCY; MUSCLE TENSION DYSPHONIA; VOICING OFFSET; ONSET; HYPERFUNCTION; SEVERITY; SPEAKERS; TASK AB Objectives: This study characterized the relationship between relative fundamental frequency (RFF) and listeners' perceptions of vocal effort and overall spasmodic dysphonia severity in the voices of 19 individuals with adductor spasmodic dysphonia. Methods: Twenty inexperienced listeners evaluated the vocal effort and overall severity of voices using visual analog scales. The squared correlation coefficients (R-2) between average vocal effort and overall severity and RIFE measures were calculated as a function of the number of acoustic instances used for the RFF estimate (from 1 to 9, of a total of 9 voiced-voiceless-voiced instances). Results: Increases in the number of acoustic instances used for the RFF average led to increases in the variance predicted by the RFF at the first cycle of voicing onset (onset RFF) in the perceptual measures; the use of 6 or more instances resulted in a stable estimate. The variance predicted by the onset RFF for vocal effort (R-2 range, 0.06 to 0.43) was higher than that for overall severity (R-2 range, 0.06 to 0.35). The offset RFF Was not related to the perceptual measures, irrespective of the sample size. Conclusions: This study indicates that onset RFF measures are related to perceived vocal effort in patients with adductor spasmodic dysphonia. These results have implications for measuring outcomes in this population. C1 [Eadie, Tanya L.] Univ Washington, Dept Speech & Hearing Sci, Seattle, WA 98195 USA. [Stepp, Cara E.] Boston Univ, Dept Speech Language & Hearing Sci, Boston, MA 02215 USA. RP Stepp, CE (reprint author), Boston Univ, Dept Speech Language & Hearing Sci, 635 Commonwealth Ave, Boston, MA 02215 USA. CR [Anonymous], 2008, PRAAT DOING PHON COM Dedo HH, 1980, SPASTIC DYSPHONIA SU Eadie TL, 2002, J ACOUST SOC AM, V112, P3014, DOI 10.1121/1.1518983 Eadie TL, 2007, ANN OTO RHINOL LARYN, V116, P695 Erickson ML, 2003, AM J SPEECH-LANG PAT, V12, P416, DOI 10.1044/1058-0360(2003/087) Fairbanks G, 1960, VOICE ARTICULATION D Goberman AM, 2008, J VOICE, V22, P178, DOI 10.1016/j.jvoice.2006.07.006 Houtz DR, 2010, LARYNGOSCOPE, V120, P749, DOI 10.1002/lary.20741 IZDEBSKI K, 1992, J VOICE, V6, P306, DOI 10.1016/S0892-1997(05)80027-X Kempster GB, 2009, AM J SPEECH-LANG PAT, V18, P124, DOI 10.1044/1058-0360(2008/08-0017) Langeveld TPM, 2000, ANN OTO RHINOL LARYN, V109, P741 Ludlow CL, 2009, CURR OPIN OTOLARYNGO, V17, P160, DOI 10.1097/MOO.0b013e32832aef6f Nash EA, 1996, LARYNGOSCOPE, V106, P484, DOI 10.1097/00005537-199604000-00017 OHDE RN, 1984, J ACOUST SOC AM, V75, P224, DOI 10.1121/1.390399 Robb MP, 2002, J SPEECH LANG HEAR R, V45, P446, DOI 10.1044/1092-4388(2002/035) Roy N, 2005, LARYNGOSCOPE, V115, P311, DOI 10.1097/01.mlg.0000154739.48314.ee Roy Nelson, 2003, Curr Opin Otolaryngol Head Neck Surg, V11, P144, DOI 10.1097/00020840-200306000-00002 Sapienza CM, 1999, J SPEECH LANG HEAR R, V42, P127 Stepp CE, 2011, J SPEECH LANG HEAR R, V54, P1260, DOI 10.1044/1092-4388(2011/10-0274) Stepp CE, 2010, J SPEECH LANG HEAR R, V53, P1220, DOI 10.1044/1092-4388(2010/09-0234) Stepp CE, 2012, J SPEECH LANG HEAR R, V55, P1887, DOI 10.1044/1092-4388(2012/11-0294) Stewart CF, 1997, J VOICE, V11, P95, DOI 10.1016/S0892-1997(97)80029-X Verdolini K., 2006, CLASSIFICATION MANUA, VI VERDOLINI K, 1994, J SPEECH HEAR RES, V37, P1001 Watson BC, 1998, J ACOUST SOC AM, V103, P3642, DOI 10.1121/1.423068 ZWIRNER P, 1993, J VOICE, V7, P165, DOI 10.1016/S0892-1997(05)80347-9 NR 26 TC 2 Z9 3 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD MAR PY 2013 VL 122 IS 3 BP 169 EP 176 PG 8 WC Otorhinolaryngology SC Otorhinolaryngology GA 108OG UT WOS:000316304700005 PM 23577569 ER PT J AU Kelly, EA Bock, JM Peltier, AC Oh, SJ Garrett, CG AF Kelly, Elizabeth A. Bock, Jonathan M. Peltier, Amanda C. Oh, Shin J. Garrett, C. Gaelyn TI Mitochondrial Myopathy: A Rare Cause of Early-Onset Vocal Fold Atrophy SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE atrophy; dysphonia; injection laryngoplasty; mitochondrial myopathy; speech therapy; vocal cord; vocal fold ID DIAGNOSIS; DISEASE AB Objectives: We present the second published case of laryngeal involvement in mitochondrial myopathy. Methods: A patient with laryngeal involvement of mitochondrial myopathy is presented, together with a literature review. Results: A 41-year-old man presented with progressive breathy dysphonia. His brother had mitochondrial myopathy. Biopsy of the biceps muscle demonstrated cytochrome C oxidase-negative ragged blue fibers confirming mitochondrial myopathy. Videostroboscopy showed marked vocal fold atrophy, but subsequent injection laryngoplasty did not significantly improve the patient's voice, despite improved postoperative glottic closure. Conclusions: Mitochondrial myopathy should be considered in the differential diagnosis of severe early-onset vocal fold atrophy. C1 [Kelly, Elizabeth A.; Bock, Jonathan M.] Med Coll Wisconsin, Dept Otolaryngol & Commun Sci, Div Laryngol & Profess Voice, Milwaukee, WI 53226 USA. [Peltier, Amanda C.] Vanderbilt Univ, Med Ctr, Dept Neurol, Nashville, TN USA. [Garrett, C. Gaelyn] Vanderbilt Univ, Med Ctr, Dept Otolaryngol Head & Neck Surg, Nashville, TN USA. [Oh, Shin J.] Univ Alabama Birmingham, Dept Neurol, Birmingham, AL 35294 USA. RP Bock, JM (reprint author), 9200 W Wisconsin Ave, Milwaukee, WI 53226 USA. CR CROS D, 1992, CHEST, V101, P824, DOI 10.1378/chest.101.3.824 Damrose Edward J, 2003, Curr Opin Otolaryngol Head Neck Surg, V11, P480, DOI 10.1097/00020840-200312000-00013 HARTLEY C, 1994, J LARYNGOL OTOL, V108, P685 Lange KW, 2006, HUM MOVEMENT SCI, V25, P492, DOI 10.1016/j.humov.2006.05.006 Pfeffer G, 2013, ANN MED, V45, P4, DOI 10.3109/07853890.2011.605389 Rubin AD, 2007, OTOLARYNG CLIN N AM, V40, P971, DOI 10.1016/j.otc.2007.05.005 Schaefer AM, 2005, MUSCLE NERVE, V32, P104, DOI 10.1002/mus.20319 Sewall GK, 2006, LARYNGOSCOPE, V116, P1740, DOI 10.1097/01.mlg.0000232537.58310.22 Taylor RW, 2004, NEUROMUSCULAR DISORD, V14, P237, DOI 10.1016/j.nmd.2003.12.004 Woodson G, 2008, ANN OTO RHINOL LARYN, V117, P317 NR 10 TC 0 Z9 0 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD MAR PY 2013 VL 122 IS 3 BP 177 EP 182 PG 6 WC Otorhinolaryngology SC Otorhinolaryngology GA 108OG UT WOS:000316304700006 PM 23577570 ER PT J AU Redmond, J Diamond, J Dunn, J Cohen, GS Soliman, AMS AF Redmond, Jonas Diamond, Jay Dunn, Jonathan Cohen, Gary S. Soliman, Ahmed M. S. TI Rigid Bronchoscopic Management of Complications Related to Endobronchial Stents After Lung Transplantation SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE endobronchial stent; lung transplant; rigid bronchoscopy ID EXPANDABLE NITINOL STENT; AIRWAY COMPLICATIONS; TRACHEOBRONCHIAL STRICTURES; METALLIC STENTS; BLOOD-FLOW; PLACEMENT; REMOVAL; OBSTRUCTION AB Objectives: We reviewed the utility of rigid bronchoscopy in the management of complications resulting from placement of metallic endobronchial stents after lung transplantation. Methods: A retrospective review was performed of all lung transplant patients who required metallic endobronchial stenting between 2005 and 2009. The patients' medical records were reviewed, and details regarding stent placement, complications, and removal were recorded. Results: A total of 43 metallic stents were placed in 22 patients who had unilateral or bilateral lung transplantation. Stent complications occurred in 18 cases (42%) at a mean of 285 days after placement and included stent collapse, stent breakdown, stent migration, ingrowth of granulation tissue, and coughing up of fractured pieces of stent. Of the 43 stents placed, only 4 (9%) had to be removed. Removal was readily accomplished by rigid bronchoscopic techniques, even when some endothelial ingrowth had occurred. Conclusions: Lung transplantation presents unique challenges in airway management. Endobronchial stenting plays an important role in the management of anastomotic stenosis and bronchomalacia in these patients. Although metallic stents have significant advantages, complications often arise that occasionally necessitate their removal. Rigid bronchoscopy is a valuable tool in the management of endobronchial stent complications after lung transplantation. C1 [Redmond, Jonas; Cohen, Gary S.] Temple Univ, Sch Med, Dept Diagnost Imaging, Philadelphia, PA 19140 USA. [Diamond, Jay; Dunn, Jonathan; Soliman, Ahmed M. S.] Temple Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, Philadelphia, PA 19140 USA. RP Soliman, AMS (reprint author), Temple Univ, Sch Med, 3400 N Broad St,Suite 300, Philadelphia, PA 19140 USA. CR BARMAN SA, 1988, AM J PHYSIOL, V255, pH1130 Dutau H, 2010, J HEART LUNG TRANSPL, V29, P658, DOI 10.1016/j.healun.2009.12.011 Filler RM, 1998, J PEDIATR SURG, V33, P304, DOI 10.1016/S0022-3468(98)90452-3 Fruchter O, 2010, J CARDIOTHORAC SURG, V5, DOI 10.1186/1749-8090-5-72 Kapoor BS, 2007, J VASC INTERV RADIOL, V18, P629, DOI 10.1016/j.jvir.2007.02.021 Kim JH, 2004, J VASC INTERV RADIOL, V15, P1003, DOI 10.1097/01.RVI.0000133857.09327.1A Kim JH, 2004, J VASC INTERV RADIOL, V15, P697, DOI 10.1097/01.RVI.0000133506.09685.A3 Kim JH, 2007, AM J ROENTGENOL, V188, P1033, DOI 10.2214/AJR.06.0888 Kshettry VR, 1997, ANN THORAC SURG, V63, P1576, DOI 10.1016/S0003-4975(97)83852-0 Lunn W, 2005, CHEST, V127, P2106, DOI 10.1378/chest.127.6.2106 Murthy SC, 2007, ANN THORAC SURG, V84, P401, DOI 10.1016/j.athoracsur.2007.05.018 Nam DH, 2006, ACTA RADIOL, V47, P3, DOI 10.1080/02841850500334989 Nashef S., 1992, ANN THORAC SURG, V52, P937 Saad CP, 2003, TRANSPLANTATION, V75, P1532, DOI 10.1097/01.TP.0000061229.83500.A0 Shin JH, 2003, J VASC INTERV RADIOL, V14, P1525, DOI 10.1097/01.RVI.0000099525.29957.34 Shin JH, 2006, J VASC INTERV RADIOL, V17, P657, DOI 10.1097/01.RVI.0000203803.98007.9F Song HY, 1999, RADIOLOGY, V213, P905 SPATENKA J, 1991, EUR J CARDIO-THORAC, V5, P648, DOI 10.1016/1010-7940(91)90121-Y Sundset A, 2012, RESPIRATION, V83, P245, DOI 10.1159/000334905 TAKAO M, 1991, J HEART LUNG TRANSPL, V10, P956 Thistlethwaite PA, 2008, J THORAC CARDIOV SUR, V136, P1569, DOI 10.1016/j.jtcvs.2008.08.021 US FDA, 2005, FDA PUBL HLTH NOT CO Wildevuur C R, 1970, Ann Thorac Surg, V9, P489 Zakaluzny SA, 2003, OTOLARYNG HEAD NECK, V128, P478, DOI 10.1016/mhn.2003.107 NR 24 TC 3 Z9 3 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD MAR PY 2013 VL 122 IS 3 BP 183 EP 189 PG 7 WC Otorhinolaryngology SC Otorhinolaryngology GA 108OG UT WOS:000316304700007 PM 23577571 ER PT J AU Hillel, AT Johns, MM Hapner, ER Shah, M Wise, JC Klein, AM AF Hillel, Alexander T. Johns, Michael M., III Hapner, Edie R. Shah, Manish Wise, Justin C. Klein, Adam M. TI Voice Outcomes From Subligamentous Cordectomy for Early Glottic Cancer SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE early glottic carcinoma; endoscopic laser cordectomy; voice outcome ID VOCAL FOLD SCAR; QUALITY-OF-LIFE; CLINICAL-EXPERIENCE; LASER CORDECTOMY; INJECTION AB Objectives: We evaluated the voice and vocal fold pliability outcomes of European Laryngological Society (ELS) deep type I (subepithelial) and type II (subligamentous) cordectomies for early glottic cancer. Methods: We reviewed the medical records of patients with glottic carcinoma at a tertiary care medical center between 2005 and 2011. Their procedures were stratified into ELS type I and ELS type II cordectomies. The data recorded included age, gender, tumor stage, recurrence, patient-assessed voice-related quality of life, perceptual voice evaluation, and stroboscopy. Results: Four patients were identified as having subepithelial cordectomy, and 13 as having subligamentous cordectomy. The average preoperative and postoperative voice-related quality of life scores were 65 and 74 for the ELS I cohort and 64 and 95 for the ELS II group. The preoperative and postoperative perceptual voice evaluation scores were 56 and 35 for the ELS I cohort and 45 and 21 for the ELS II cohort. The ELS I cohort had a moderately to severely reduced mucosal wave, with 75% of patients demonstrating glottic insufficiency, whereas the ELS II cohort had a mildly to moderately reduced mucosal wave, with 8% of patients demonstrating glottic insufficiency. The survival outcomes were the same. Conclusions: Patients who underwent subligamentous excision of early glottic cancer had significantly improved postoperative voice and stroboscopy scores. This finding suggests that if tumor resection reaches the vocal ligament, and minimal superficial lamina propria can be preserved, subligamentous cordectomy should be performed. C1 [Hillel, Alexander T.; Johns, Michael M., III; Hapner, Edie R.; Klein, Adam M.] Emory Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, Emory Voice Ctr, Atlanta, GA 30308 USA. [Wise, Justin C.] Oglethorpe Univ, Dept Psychol, Atlanta, GA USA. [Shah, Manish] Univ Toronto, Dept Otolaryngol Head & Neck Surg, Toronto, ON, Canada. RP Klein, AM (reprint author), Emory Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, Emory Voice Ctr,MOT, Suite 9-4400,550 Peachtree St, Atlanta, GA 30308 USA. CR Bless D M, 1987, Ear Nose Throat J, V66, P289 Blümel B, 1996, Zentralbl Gynakol, V118, P458 CASIANO RR, 1991, OTOLARYNG HEAD NECK, V104, P831 Chhetri DK, 2011, LARYNGOSCOPE, V121, P785, DOI 10.1002/lary.21417 Evers LH, 2010, EXP DERMATOL, V19, P777, DOI 10.1111/j.1600-0625.2010.01105.x Fraenkel B, 1886, ARCH KLIN CHIR, V12, P283 Gravante G, 2006, SURGERY, V139, P854, DOI 10.1016/j.surg.2006.01.024 Hogikyan ND, 1999, J VOICE, V13, P557, DOI 10.1016/S0892-1997(99)80010-1 JACKSON DM, 1953, BRIT J SURG, V40, P588, DOI 10.1002/bjs.18004016413 Karajanagi SS, 2011, ANN OTO RHINOL LARYN, V120, P175 Mortensen M, 2010, CURR OPIN OTOLARYNGO, V18, P487, DOI 10.1097/MOO.0b013e32833fe112 Mortensen MM, 2008, LARYNGOSCOPE, V118, P1884, DOI 10.1097/MLG.0b013e31817d7546 Paniello RC, 2008, ANN OTO RHINOL LARYN, V117, P437 Remacle M, 2000, EUR ARCH OTO-RHINO-L, V257, P227, DOI 10.1007/s004050050228 Roh JL, 2007, HEAD NECK-J SCI SPEC, V29, P1010, DOI 10.1002/hed.20625 Steiner W, 2000, LASER MICROSURGERY L STRONG MS, 1972, ANN OTO RHINOL LARYN, V81, P791 Zeitels SM, 2002, ANN OTO RHINOL LARYN, V111, P3 NR 18 TC 4 Z9 4 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD MAR PY 2013 VL 122 IS 3 BP 190 EP 196 PG 7 WC Otorhinolaryngology SC Otorhinolaryngology GA 108OG UT WOS:000316304700008 PM 23577572 ER PT J AU Young, VN Smith, LJ Rosen, C AF Young, VyVy N. Smith, Libby J. Rosen, Clark TI Voice Outcome Following Acute Unilateral Vocal Fold Paralysis SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE laryngeal electromyography; quality of life; vocal fold injection; vocal fold paralysis; voice outcome ID INJECTION MEDIALIZATION; HANDICAP INDEX-10; ELECTROMYOGRAPHY; LARYNGOPLASTY AB Objectives: We assessed voice outcomes following unilateral vocal fold paralysis (UVFP). Methods: We performed a retrospective chart review of 72 patients with UVFP proven by laryngeal electromyography, including their Voice Handicap Index-10 (VHI-10) scores at presentation and at the study end point (at the return of vocal fold motion or before the decision regarding definitive treatment). Results: The average VHI-10 score on presentation was 26.9 of 40 (27.2 for patients who recovered motion and 26.7 for those who did not; p = 0.847). A recovery of vocal fold motion was experienced by 35% of patients, and 76.4% of patients underwent temporary vocal fold injection. For the patients who recovered motion, the average changes in VHI-10 score were -22.3 for those with injection and -11.4 for those without (p = 0.027). For patients without motion recovery, the average changes in VHI-10 score were -9.5 for those with injection and -0.8 for those without (p = 0.027). At the study end point, 84% of patients with return of motion had normal VHI-10 scores, in contrast to 21% of patients without motion recovery (p = 0.0009). Conclusions: A return of vocal fold motion is a vital determinant of voice outcome in patients with UVFP. However, despite recovery of vocal fold motion, 16% of patients in this study still had significant voice handicap. In contrast, 21% of patients without motion recovery had normal VHI-10 scores. This information can be used to counsel patients on voice outcome (precluding permanent treatment) with and without recovery of motion. There may be long-term voice benefit from early temporary vocal fold injection. C1 [Young, VyVy N.; Smith, Libby J.; Rosen, Clark] Univ Pittsburgh, Voice Ctr, Dept Otolaryngol Head & Neck Surg, Sch Med, Pittsburgh, PA 15219 USA. RP Young, VN (reprint author), Univ Pittsburgh, Voice Ctr, 1400 Locust St,Suite 2100,Bldg D, Pittsburgh, PA 15219 USA. CR Arffa RE, 2012, J VOICE, V26, P462, DOI 10.1016/j.jvoice.2011.04.006 Arviso LC, 2010, LARYNGOSCOPE, V120, P2237, DOI 10.1002/lary.21143 Dworkin JP, 2009, J NEUROL SCI, V284, P56, DOI 10.1016/j.jns.2009.04.004 Friedman AD, 2010, LARYNGOSCOPE, V120, P2042, DOI 10.1002/lary.21097 Munin MC, 2003, ARCH PHYS MED REHAB, V84, P1150, DOI 10.1016/S0003-9993(03)00146-1 Rosen CA, 2004, LARYNGOSCOPE, V114, P1549, DOI 10.1097/00005537-200409000-00009 Rosenthal LHS, 2007, LARYNGOSCOPE, V117, P1864, DOI 10.1097/MLG.0b013e3180de4d49 Smith LJ, 2012, LARYNGOSCOPE, V122, P854, DOI 10.1002/lary.21884 Statham MM, 2010, LARYNGOSCOPE, V120, P285, DOI 10.1002/lary.20629 Sulica L, 2008, LARYNGOSCOPE, V118, P1303, DOI 10.1097/MLG.0b013e31816f27ee Sulica L, 2010, LARYNGOSCOPE, V120, P319, DOI 10.1002/lary.20737 Wang CC, 2008, ARCH OTOLARYNGOL, V134, P380, DOI 10.1001/archotol.134.4.380 Yamada M, 1983, Auris Nasus Larynx, V10 Suppl, pS1 Yung KC, 2011, LARYNGOSCOPE, V121, P2191, DOI 10.1002/lary.21965 NR 14 TC 6 Z9 6 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD MAR PY 2013 VL 122 IS 3 BP 197 EP 204 PG 8 WC Otorhinolaryngology SC Otorhinolaryngology GA 108OG UT WOS:000316304700009 PM 23577573 ER PT J AU Stevens, MS Chang, A Simpson, CB AF Stevens, Matthew S. Chang, Andrew Simpson, C. Blake TI Supraglottic Stenosis: Etiology and Treatment of a Rare Condition SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article; Proceedings Paper CT Meeting of the American-Broncho-Esophagological-Association CY APR 18-19, 2012 CL San Diego, CA SP Amer Broncho Esophagol Assoc DE airway; carbon dioxide laser; laryngotracheal stenosis; pulsed KTP laser; radiation therapy; supraglottic stenosis ID LARYNGOTRACHEAL STENOSIS; MANAGEMENT; CANCER AB Objectives: Although laryngotracheal stenosis is well described in the literature, the vast majority of cases are of stenosis at either the subglottic or glottic level. Supraglottic stenosis is an unusual subset of laryngotracheal stenosis that has distinctly different causes, symptoms, and treatment options. Methods: A retrospective chart review was conducted on all adult patients at our institution with a diagnosis of supraglottic stenosis. Clinical records, videolaryngoscopic examinations, and operative and clinic procedure records were reviewed. All patients had a minimum follow-up of 12 months. Results: Eight patients with supraglottic stenosis were identified. Five (62.5%) had a history of radiation therapy, and the remaining 3 cases were associated with autoimmune disorders. Our data revealed a frequent association with dysphagia (7 of 8 cases, or 87.5%), including 2 patients with complete pharyngoesophageal stricture and 3 who required a percutaneous gastrostomy tube. All of the patients required more than 1 surgical intervention because of symptomatic recurrent airway stenosis. Three patients underwent successful endoscopic treatment with a carbon dioxide laser in the operating room. One of these patients and 5 additional patients were successfully managed with pulsed KTP laser treatment in the clinic setting without complications. We observed 2 cases of acute intraoperative supraglottic edema in the setting of suspension laryngoscopy and jet ventilation, 1 of which necessitated emergent tracheostomy. Conclusions: Supraglottic stenosis is a rare condition that is often associated with external-beam radiation or autoimmune disorders. All of the patients in our series experienced some degree of symptomatic airway obstruction that required management. The majority also had coexisting dysphagia, often associated with pharyngeal or esophageal stricture. Despite the favorable response to endoscopic treatment, all patients eventually required additional procedures because of symptomatic recurrence of their stenosis. Although endoscopic surgical treatment with a carbon dioxide laser in the operating room setting is a viable option, office-based treatment with a pulsed KTP laser appears to be an effective and potentially safer alternative. C1 [Stevens, Matthew S.; Chang, Andrew; Simpson, C. Blake] Univ Texas Hlth Sci Ctr San Antonio, Dept Otolaryngol Head & Neck Surg, San Antonio, TX 78229 USA. [Simpson, C. Blake] Univ Texas Hlth Sci Ctr San Antonio, Univ Texas Voice Ctr, San Antonio, TX 78229 USA. RP Simpson, CB (reprint author), Univ Texas Hlth Sci Ctr San Antonio, Dept Otolaryngol Head & Neck Surg, 8300 Floyd Curl Dr, San Antonio, TX 78229 USA. CR Amin Milan R, 2004, Ear Nose Throat J, V83, P10 Belloso Antonio, 2008, Ear Nose Throat J, V87, pE11 Chen YW, 2006, EUR ARCH OTO-RHINO-L, V263, P210, DOI 10.1007/s00405-005-1011-5 Citrin D, 2009, INT J RADIAT ONCOL, V74, P1040, DOI 10.1016/j.ijrobp.2008.09.053 COX JD, 1995, INT J RADIAT ONCOL, V31, P1341, DOI 10.1016/0360-3016(95)00060-C Eisbruch A, 2004, INT J RADIAT ONCOL, V60, P1425, DOI 10.1016/j.ijrobp.2004.05.050 Herrington HC, 2006, LARYNGOSCOPE, V116, P1553, DOI 10.1097/01.mlg.0000228006.21941.12 Krishna PD, 2006, AM J OTOLARYNG, V27, P355, DOI 10.1016/j.amjoto.2005.11.021 Leventhal DD, 2009, ARCH OTOLARYNGOL, V135, P467, DOI 10.1001/archoto.2009.28 Monnier P, 2005, EUR ARCH OTO-RHINO-L, V262, P602, DOI 10.1007/s00405-005-0948-8 Oosthuizen JC, 2010, AM J OTOLARYNG, V32, P426 Postma Gregory N, 2004, Ear Nose Throat J, V83, P22 Rosen CA, 2009, LARYNGOSCOPE, V119, pS185, DOI 10.1002/lary.20712 NR 13 TC 0 Z9 1 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD MAR PY 2013 VL 122 IS 3 BP 205 EP 209 PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA 108OG UT WOS:000316304700010 PM 23577574 ER PT J AU Huang, T Chen, MH Wu, MY Wu, XY AF Huang, Tian Chen, Mao-Huai Wu, Ming-Yao Wu, Xian-Ying TI Correlation Between Expression of Extracellular Matrix Metalloproteinase Inducer and Matrix Metalloproteinase-2 and Cervical Lymph Node Metastasis of Nasopharyngeal Carcinoma SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE EMMPRIN; extracellular matrix metalloproteinase inducer; immunohistochemistry; matrix metalloproteinase-2; MMP-2; nasopharyngeal carcinoma; neoplasm metastasis ID SQUAMOUS-CELL CARCINOMA; MEMBRANE-PROTEIN 1; EMMPRIN CD147; MATRIX-METALLOPROTEINASE-9; INVASION; STIMULATION; FIBROBLASTS; PROGNOSIS; BRAIN AB Objectives: We evaluated the expression of extracellular matrix metalloproteinase inducer (EMMPRIN) and matrix metalloproteinase-2 (MMP-2) in nasopharyngeal carcinoma (NPC) and studied their relationship with cervical lymph node metastasis. Methods: Immunohistochemical staining was used to detect the expression of EMMPRIN and MMP-2 in specimens from patients with chronic nasopharyngitis (CN), nonmetastastic NPC (NM-NPC), and lymph node metastatic NPC (LNM-NPC). Results: The rates of positive EMMPRIN expression in CN, NM-NPC, and LNM-NPC were 13.3%, 30.0%, and 66.7%, respectively. Significant differences were found between the rates in CN and LNM-NPC (p < 0.01) and between the rates in NM-NPC, and LNM-NPC (p = 0.01). In the LNM-NPC group, NPC cells had a higher rate of expression of EMMPRIN in tumor metastases than in the primary tumor (81.8% versus 66.7%; p = 0.01). The rates of positive MMP-2 expression in CN, NM-NPC, and LNM-NPC were 13.3%, 35.0%, and 60.6%, respectively. A significant difference was found between the rates in CN and LNM-NPC (p < 0.01). In the LNM-NPC group, NPC cells had a higher rate of MMP-2 expression in tumor metastases than in the primary tumor (72.7% versus 60.6%; p < 0.01). The expressions of MMP-2 and EMMPRIN were highly correlated (rs = 0.466; p < 0.01). Conclusions: Nasopharyngeal carcinoma cells may attain enhanced metastastic capability through the expression of MMP-2 induced by EMMPRIN. C1 [Huang, Tian] Shantou Univ, Coll Med, Inst Inflammat & Immune Dis, Shantou 515031, Peoples R China. [Chen, Mao-Huai; Wu, Ming-Yao; Wu, Xian-Ying] Shantou Univ, Coll Med, Dept Pathol, Shantou 515031, Peoples R China. RP Chen, MH (reprint author), Shantou Univ, Coll Med, Dept Pathol, 22 Xinling Rd, Shantou 515031, Peoples R China. FU Department of Science and Technology of the Guangdong Province, People's Republic of China [2002C30316]; Guangdong Provincial Department of Health, Guangdong, People's Republic of China [A2002422] FX From the Institute of Inflammation and Immune Diseases (Huang) and the Department of Pathology (Chen, M.-Y. Wu, X.-Y. Wu), Shantou University Medical College, Shantou, People's Republic of China. This study was supported by the Department of Science and Technology of the Guangdong Province (2002C30316) and the Guangdong Provincial Department of Health (A2002422), Guangdong, People's Republic of China. CR Bar-Sela G, 2005, PEDIATR BLOOD CANCER, V45, P291, DOI 10.1002/pbc.20264 Bordador LC, 2000, INT J CANCER, V85, P347, DOI 10.1002/(SICI)1097-0215(20000201)85:3<347::AID-IJC9>3.3.CO;2-R Caudroy S, 1999, J HISTOCHEM CYTOCHEM, V47, P1575 Chen MH, 2003, HEAD NECK-J SCI SPEC, V25, P395, DOI 10.1002/hed.10222 Chen X, 2001, J CUTAN PATHOL, V28, P184, DOI 10.1034/j.1600-0560.2001.028004184.x Davidson B, 2003, CLIN EXP METASTAS, V20, P621, DOI 10.1023/A:1027347932543 Du ZM, 2009, INT J CANCER, V125, P1832, DOI 10.1002/ijc.24531 Guo HM, 1997, J BIOL CHEM, V272, P24 Horikawa T, 2000, CANCER, V89, P715, DOI 10.1002/1097-0142(20000815)89:4<715::AID-CNCR1>3.0.CO;2-9 Leroy-Dudal J, 2005, INT J CANCER, V114, P531, DOI 10.1002/ijc.20778 Li Zhi, 2004, Ai Zheng, V23, P130 LIOTTA LA, 1986, CANCER RES, V46, P1 Lu J, 2003, CANCER RES, V63, P256 Mai Hai-Qiang, 2005, Ai Zheng, V24, P611 Miyazaki T, 2004, BRIT J CANCER, V91, P1556, DOI 10.1038/sj.bjc.6602185 MOSCATELLI D, 1988, BIOCHIM BIOPHYS ACTA, V948, P67, DOI 10.1016/0304-419X(88)90005-4 Reimers N, 2004, CLIN CANCER RES, V10, P3422, DOI 10.1158/1078-0432.CCR-03-0610 Sameshima T, 2000, INT J CANCER, V88, P21, DOI 10.1002/1097-0215(20001001)88:1<21::AID-IJC4>3.0.CO;2-S Sameshima T, 2000, CANCER LETT, V157, P177, DOI 10.1016/S0304-3835(00)00485-7 Sehgal G, 1998, AM J PATHOL, V152, P591 Stearns ME, 1997, INVAS METAST, V17, P62 STETLERSTEVENSON WG, 1993, ANNU REV CELL BIOL, V9, P541, DOI 10.1146/annurev.cb.09.110193.002545 Sugiura Y, 1998, CANCER RES, V58, P2209 Sun JX, 2001, CANCER RES, V61, P2276 Suzuki S, 2004, EXP CELL RES, V293, P259, DOI 10.1016/j.yexer.2003.10.010 Thorns C, 2002, ANTICANCER RES, V22, P1983 Yoshizaki T, 1998, P NATL ACAD SCI USA, V95, P3621, DOI 10.1073/pnas.95.7.3621 Yu WW, 2009, PATHOL RES PRACT, V205, P709, DOI 10.1016/j.prp.2009.05.010 Zanation AM, 2004, OTOLARYNG HEAD NECK, V131, P577, DOI 10.1016/j.otohns.2004.05.023 Zhang Ming-Man, 2005, Zhonghua Gan Zang Bing Za Zhi, V13, P267 NR 30 TC 4 Z9 5 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD MAR PY 2013 VL 122 IS 3 BP 210 EP 215 PG 6 WC Otorhinolaryngology SC Otorhinolaryngology GA 108OG UT WOS:000316304700011 PM 23577575 ER PT J AU Park, YM Kim, WS Byeon, HK De Virgilio, A Lee, SY Kim, SH AF Park, Young Min Kim, Won Shik Byeon, Hyung Kwon De Virgilio, Armando Lee, Sei Young Kim, Se-Heon TI Clinical Outcomes of Transoral Robotic Surgery for Head and Neck Tumors SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE head and neck neoplasm; minimally invasive surgical procedure; robotics; transoral robotic surgery ID CANCER; MANDIBULOTOMY; COMPLICATIONS; LARYNGECTOMY; EXPERIENCE; CARCINOMA; MODEL AB Objectives: In order to reduce treatment-related morbidity rates and increase patients' quality of life, robot-assisted surgery using the da Vinci surgical system (Intuitive Surgical Inc, Sunnyvale, California) has been studied actively in the field of head and neck surgery. This study analyzes our experiences therewith in order to evaluate the feasibility and efficacy of robot-assisted surgery via a transoral approach in the head and neck area. Methods: Between April 2008 and December 2011, 141 patients were treated with robot-assisted surgery via a transoral approach. Results: Robot-assisted surgeries were successfully completed via a transoral approach in all patients. The mean robotic operative time was 69.3 minutes, and the mean time for setup of the robotic system was 10.4 minutes. The average blood loss during the operation was 29.6 mL (range, 0 to 300 mL). Patients who underwent robot-assisted surgery were satisfied with their cosmetic results and treatment outcomes. Conclusions: Robot-assisted surgery via a transoral approach was confirmed to be feasible and efficient in the field of head and neck surgery. Further research is needed to investigate the long-term functional and oncological results of robot-assisted surgery. C1 [Park, Young Min; Kim, Won Shik; Byeon, Hyung Kwon; Kim, Se-Heon] Yonsei Univ, Coll Med, Dept Otorhinolaryngol, Seoul 120752, South Korea. [Lee, Sei Young] Chung Ang Univ, Coll Med, Dept Otorhinolaryngol, Seoul 156756, South Korea. [De Virgilio, Armando] Univ Roma La Sapienza, Dept Otorhinolaryngol, I-00185 Rome, Italy. RP Kim, SH (reprint author), Yonsei Univ, Coll Med, Dept Otorhinolaryngol, 50 Yonsei Ro, Seoul 120752, South Korea. RI De Virgilio, Armando/G-8710-2012 CR Allendorf JDF, 1997, SURG ENDOSC-ULTRAS, V11, P427, DOI 10.1007/s004649900383 Boudreaux BA, 2009, ARCH OTOLARYNGOL, V135, P397, DOI 10.1001/archoto.2009.24 Nelson H, 2004, NEW ENGL J MED, V350, P2050 CUSCHIERI A, 1991, AM J SURG, V161, P385, DOI 10.1016/0002-9610(91)90603-B Franklin ME, 1996, DIS COLON RECTUM, V39, pS35, DOI 10.1007/BF02053804 Genden EM, 2009, HEAD NECK-J SCI SPEC, V31, P283, DOI 10.1002/hed.20972 Holsinger FC, 2005, ARCH OTOLARYNGOL, V131, P583, DOI 10.1001/archotol.131.7.583 Nam Woong, 2006, Oral Surg Oral Med Oral Pathol Oral Radiol Endod, V101, pe65, DOI 10.1016/j.tripleo.2005.07.019 Park YM, 2009, ORAL ONCOL, V45, pE62, DOI 10.1016/j.oraloncology.2009.02.012 Park YM, 2009, J LAPAROENDOSC ADV S, V19, P361, DOI 10.1089/lap.2008.0320 Park YM, 2010, ORAL ONCOL, V46, P597, DOI 10.1016/j.oraloncology.2010.05.003 Reiter D, 2004, OTOLARYNG HEAD NECK, V131, P339, DOI 10.1016/j.otohns.2004.03.031 Wang CC, 2005, LARYNGOSCOPE, V115, P1963, DOI 10.1097/01.mlg.0000178374.29219.5e Weinstein GS, 2007, ARCH OTOLARYNGOL, V133, P1220, DOI 10.1001/archotol.133.12.1220 Weinstein GS, 2005, LARYNGOSCOPE, V115, P1315, DOI 10.1097/01.MLG.0000170848.76045.47 Weinstein GS, 2007, ANN OTO RHINOL LARYN, V116, P19 NR 16 TC 2 Z9 3 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD FEB PY 2013 VL 122 IS 2 BP 73 EP 84 PG 12 WC Otorhinolaryngology SC Otorhinolaryngology GA 200TP UT WOS:000323094100002 PM 23534121 ER PT J AU Hong, JC Kim, SW Lee, HS Han, YJ Park, HS Lee, KD AF Hong, Jong Chul Kim, Sung Won Lee, Hyoung Shin Han, Young Jin Park, Heon Soo Lee, Kang Dae TI Salvage Transoral Laser Supraglottic Laryngectomy After Radiation Failure: A Report of Seven Cases SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE carbon dioxide laser; radiation failure; salvage laryngectomy; supraglottic cancer ID SUPRACRICOID PARTIAL LARYNGECTOMY; RECURRENT LARYNGEAL; FUNCTIONAL OUTCOMES; CARCINOMA; SURGERY; CANCER; MICROSURGERY; RADIOTHERAPY; MANAGEMENT AB Objectives: We evaluated the oncological and functional outcomes of salvage transoral laser supraglottic laryngectomy after radiation failure. In addition, we demonstrated the usefulness of laser surgery in patients with recurrent supraglottic cancer. Methods: Between December 1999 and May 2011,7 patients (6 men and 1 woman) underwent transoral laser supraglottic laryngectomy after radiation failure. We conducted 4 different types of endoscopic supraglottic laryngectomy. In the cases with lymph node metastasis, we performed neck dissection at the time of laser surgery. Results: All patients had recurrent squamous cell carcinoma confirmed on the surgical specimen. Two patients were classified as having T1 disease, 2 as having T2 disease, and 3 as having T3 disease with preepiglottic space involvement. The 2- and 5-year overall survival rates were 85.7% and 68.6%, respectively. There was a recurrence at 8 months of follow-up after laser surgery in 1 patient; he underwent successful salvage total laryngectomy. The ultimate local control rate was 100%, and the laryngeal preservation rate was 85.7%. The hospitalization times ranged from 2 to 32 days (mean, 15.6 days). The mean decannulation time was 10.7 days (range, 5 to 30 days). All patients started oral feeding within 1 to 3 days after surgery. Conclusions: Salvage transoral laser supraglottic laryngectomy following radiation failure seems a feasible and oncologically safe procedure in recurrent supraglottic cancers ranging from T1 to selected T3 with minimal preepiglottic space involvement. It can be an option for minimally invasive organ preservation surgery with lesser morbidity for recurrent supraglottic cancer. C1 [Hong, Jong Chul; Park, Heon Soo] Dong A Univ, Coll Med, Dept Otolaryngol Head & Neck Surg, Pusan, South Korea. [Kim, Sung Won; Lee, Hyoung Shin; Han, Young Jin; Lee, Kang Dae] Kosin Univ, Coll Med, Dept Otolaryngol Head & Neck Surg, Pusan 602715, South Korea. RP Lee, KD (reprint author), Kosin Univ, Coll Med, Dept Otolaryngol Head & Neck Surg, 34 Amnam Dong, Pusan 602715, South Korea. FU Dong-A University FX This study was supported by research funds from Dong-A University. CR Ambrosch P, 1998, ANN OTO RHINOL LARYN, V107, P680 Ambrosch Petra, 2007, Curr Opin Otolaryngol Head Neck Surg, V15, P82, DOI 10.1097/MOO.0b013e3280147336 Bussu F, 2009, HEAD NECK-J SCI SPEC, V31, P1196, DOI 10.1002/hed.21085 Cabanillas R, 2004, HEAD NECK-J SCI SPEC, V26, P653, DOI 10.1002/hed.20063 Clark J, 2005, ANZ J SURG, V75, P958, DOI 10.1111/j.1445-2197.2005.03587.x Ganly I, 2009, HEAD NECK-J SCI SPEC, V31, P338, DOI 10.1002/hed.20975 Grant DG, 2008, OTOLARYNG HEAD NECK, V138, P606, DOI 10.1016/j.otohns.2007.12.046 Holsinger FC, 2006, HEAD NECK-J SCI SPEC, V28, P779, DOI 10.1002/hed.20415 Laccourreye O, 1996, LARYNGOSCOPE, V106, P495, DOI 10.1097/00005537-199604000-00019 Laccourreye O, 1998, LARYNGOSCOPE, V108, P339, DOI 10.1097/00005537-199803000-00006 Marioni G, 2008, CURR OPIN OTOLARYNGO, V16, P141, DOI 10.1097/MOO.0b013e3282f495a2 Nibu K, 1997, HEAD NECK-J SCI SPEC, V19, P116, DOI 10.1002/(SICI)1097-0347(199703)19:2<116::AID-HED5>3.0.CO;2-7 Pellini R, 2008, HEAD NECK-J SCI SPEC, V30, P372, DOI 10.1002/hed.20709 Peretti G, 2006, ANN OTO RHINOL LARYN, V115, P827 QUAYUM MA, 1978, CLIN RADIOL, V29, P21, DOI 10.1016/S0009-9260(78)80158-5 Remacle M, 2009, EUR ARCH OTO-RHINO-L, V266, P993, DOI 10.1007/s00405-008-0901-8 Remacle M, 2009, OTOLARYNG HEAD NECK, V141, P374, DOI 10.1016/j.otohns.2009.06.088 Rodrigo Juan Pablo, 2008, Acta Otorrinolaringol Esp, V59, P345 Rodrigo JP, 2008, HEAD NECK-J SCI SPEC, V30, P658, DOI 10.1002/hed.20811 Roh Jong-Lyel, 2008, J Surg Oncol, V98, P184, DOI 10.1002/jso.21101 Rudert HH, 1999, ANN OTO RHINOL LARYN, V108, P819 Spriano G, 2002, HEAD NECK-J SCI SPEC, V24, P759, DOI 10.1002/hed.10117 Steiner W, 2000, ENDOSCOPIC LASER SUR Watters GWR, 2000, CLIN OTOLARYNGOL, V25, P146, DOI 10.1046/j.1365-2273.2000.00333.x NR 24 TC 1 Z9 1 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD FEB PY 2013 VL 122 IS 2 BP 85 EP 90 PG 6 WC Otorhinolaryngology SC Otorhinolaryngology GA 200TP UT WOS:000323094100003 PM 23534122 ER PT J AU Di Lella, F Merkus, P Di Trapani, G Taibah, A Guida, M Sanna, M AF Di Lella, Filippo Merkus, Paul Di Trapani, Giuseppe Taibah, Abdelkader Guida, Maurizio Sanna, Mario TI Vestibular Schwannoma in the Only Hearing Ear: Role of Cochlear Implants SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE acoustic neuroma; cochlear implant; hearing loss; only hearing ear; single-sided deafness; vestibular schwannoma ID BRAIN-STEM IMPLANT; NEUROFIBROMATOSIS TYPE-2 PATIENTS; UNILATERAL ACOUSTIC NEUROMAS; TERM-FOLLOW-UP; DECISION-MAKING; MANAGEMENT; SURGERY; REMOVAL; PATIENT AB Objectives: We sought to delineate the role of cochlear implantation in the management of vestibular schwannoma or other cerebellopontine angle tumors in the only hearing ear. Methods: We performed a retrospective analysis in a quaternary referral skull base center of all patients who were affected by vestibular schwannoma (or other lesions of the cerebellopontine angle) in the only hearing ear and received a cochlear implant before or after tumor treatment (surgery or radiotherapy) or during the wait-and-scan follow-up. We also performed a systematic review of the English-language literature. Results: The clinical and audiological results of 10 patients are reported. All patients were managed with contralateral cochlear implantation. In 7 patients, cochlear implantation was perfouned before tumor removal, while hearing in the ear with the tumor was still present. In 3 patients, the implant was placed after curative surgery. Nine of the 10 patients routinely use their implant with subjective benefit and fairly good auditory performance (median disyllabic word recognition, 90%; median sentence comprehension, 75%). The literature search retrieved no major series with assessment of the long-term efficacy of cochlear implantation in this rare clinical scenario. Conclusions: Patients affected by vestibular schwannoma in their only hearing ear may significantly benefit from a cochlear implant on the contralateral side prior to tumor removal. Recent and significant hearing deterioration and tumor growth represent the main indications for cochlear implantation. C1 [Di Lella, Filippo; Merkus, Paul; Di Trapani, Giuseppe; Taibah, Abdelkader; Guida, Maurizio; Sanna, Mario] Grp Otol Piacenza Roma, I-29121 Piacenza, Italy. RP Di Lella, F (reprint author), Grp Otol Piacenza Roma, Via Emmanueli 42, I-29121 Piacenza, Italy. FU AINOT (Associazione Italiana Neuro Otologica) FX This study was supported by a grant from AINOT (Associazione Italiana Neuro Otologica). CR Aristegui M, 2005, OTOL NEUROTOL, V26, P205 Branch MP, 2002, OTOLARYNG HEAD NECK, V127, P483, DOI 10.1067/mhn.2002.129809 Chu SM, 2007, EUR ARCH OTO-RHINO-L, V264, P693, DOI 10.1007/s00405-006-0236-2 Crane BT, 2010, OTOL NEUROTOL, V31, P1215, DOI 10.1097/MAO.0b013e3181ec1d61 Dispenza F, 2008, AUDIOL NEURO-OTOL, V13, P53, DOI 10.1159/000108109 GADRE AK, 1990, LARYNGOSCOPE, V100, P948 Grayeli AB, 2008, OTOL NEUROTOL, V29, P1140, DOI 10.1097/MAO.0b013e31818b6238 Lin VYW, 2005, LARYNGOSCOPE, V115, P292, DOI 10.1097/mlg.0000154736.38904.c3 LOWNIE SP, 1991, J NEUROSURG, V74, P422, DOI 10.3171/jns.1991.74.3.0422 Massick DD, 2000, LARYNGOSCOPE, V110, P1843, DOI 10.1097/00005537-200011000-00015 NAGUIB MB, 1994, SKULL BASE SURG, V4, P32, DOI 10.1055/s-2008-1058986 Neff BA, 2007, LARYNGOSCOPE, V117, P1069, DOI 10.1097/MIG.0b01I3e31804b1ae7 PENSAK ML, 1991, SKULL BASE SURG, V1, P93, DOI 10.1055/s-2008-1056987 Ramsden R, 2005, OTOL NEUROTOL, V26, P261, DOI 10.1097/00129492-200503000-00023 Sanna M, 2012, OTOL NEUROTOL, V33, P154, DOI 10.1097/MAO.0b013e318241bc71 Sanna M, 2006, LARYNGOSCOPE, V116, P1700, DOI 10.1097/01.mlg.0000231739.79208.97 Shin YJ, 1998, AM J OTOL, V19, P649 Stangerup SE, 2008, J LARYNGOL OTOL, V122, P673, DOI 10.1017/S0022215107001077 TALBOT A, 1994, J LARYNGOL OTOL, V108, P983 THEDINGER BA, 1993, LARYNGOSCOPE, V103, P976 Tschudi DC, 2000, AM J OTOL, V21, P722 Vincenti V, 2008, AUDIOL NEURO-OTOL, V13, P273, DOI 10.1159/000115437 Wackym PA, 2004, LARYNGOSCOPE, V114, P1355, DOI 10.1097/00005537-200408000-00007 NR 23 TC 1 Z9 1 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD FEB PY 2013 VL 122 IS 2 BP 91 EP 99 PG 9 WC Otorhinolaryngology SC Otorhinolaryngology GA 200TP UT WOS:000323094100004 PM 23534123 ER PT J AU Kelly, EA Koszewski, IJ Jaradeh, SS Merati, AL Blumin, JH Bock, JM AF Kelly, Elizabeth A. Koszewski, Ian J. Jaradeh, Safwan S. Merati, Albert L. Blumin, Joel H. Bock, Jonathan M. TI Botulinum Toxin Injection for the Treatment of Upper Esophageal Sphincter Dysfunction SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE botulinum toxin; cricopharyngeal muscle; dysphagia; upper esophageal sphincter ID CRICOPHARYNGEAL DYSPHAGIA; OROPHARYNGEAL DYSPHAGIA; GUIDED INJECTION; MUSCLE; ACHALASIA; MYOTOMY AB Objectives: We sought to review the dysphagia-related outcomes and quality of life in a series of patients with upper esophageal sphincter (UES) dysfunction treated with cricopharyngeal (CP) botulinum toxin (BTX) injection, and to identify patient characteristics or CP muscle histologic features that predict efficacy of BTX injection. Methods: A retrospective chart review was performed on patients with UES dysfunction who underwent CP BTX injection. Dysphagia-related quality-of-life questionnaires based on the Eating Assessment Tool (EAT-10) were mailed to patients. Results: Forty-nine patients (30 female, 19 male; average age, 59 +/- 16 years) with UES dysfunction have been treated at our institution with CP BTX injection since 2000. Seventeen of these patients also underwent CP myotomy. Injections of BTX were occasionally repeated after the treatment effect subsided, and the BTX dose varied widely (average, 39 +/- 19 units). Improvement in symptoms was noted by 65% of patients. The overall complication rate was minimal, although many patients complained of transient worsening of dysphagia after CP BTX injection. Biopsy specimens of the CP muscle were evaluated in the subset of patients with CP BTX injection who proceeded to myotomy, with results of neuropathic, myopathic, and mixed histologic subtypes. The EAT-10 scores demonstrated a general trend toward improved swallowing outcomes after CP BTX injection. Conclusions: This study reviewed findings from the largest published series of BTX treatment of UES dysfunction and evaluated the efficacy, patient satisfaction, and complications of this procedure. Dysphagia-related quality-of-life outcomes appear to be improved after CP BTX injection. C1 [Kelly, Elizabeth A.; Koszewski, Ian J.; Blumin, Joel H.; Bock, Jonathan M.] Med Coll Wisconsin, Dept Otolaryngol & Commun Sci, Div Laryngol & Profess Voice, Milwaukee, WI 53226 USA. [Jaradeh, Safwan S.] Med Coll Wisconsin, Dept Neurol, Milwaukee, WI 53226 USA. [Merati, Albert L.] Univ Washington, Dept Otolaryngol Head & Neck Surg, Seattle, WA 98195 USA. RP Bock, JM (reprint author), Med Coll Wisconsin, Dept Otolaryngol & Commun Sci, 9200 W Wisconsin Ave, Milwaukee, WI 53226 USA. CR Alberty J, 2000, LARYNGOSCOPE, V110, P1151, DOI 10.1097/00005537-200007000-00016 Alfonsi E, 2010, J NEUROL NEUROSUR PS, V81, P54, DOI 10.1136/jnnp.2009.174698 Allen J, 2010, LARYNGOSCOPE, V120, P1498, DOI 10.1002/lary.21002 Atkinson SI, 1997, J OTOLARYNGOL, V26, P273 Belafsky PC, 2008, ANN OTO RHINOL LARYN, V117, P919 Blitzer A, 1997, OTOLARYNG HEAD NECK, V116, P328 Brant CQ, 1999, DIS ESOPHAGUS, V12, P68, DOI 10.1046/j.1442-2050.1999.00015.x Chiu MJ, 2004, DYSPHAGIA, V19, P52, DOI 10.1007/s00455-003-0029-3 Dauer E, 2006, OTOLARYNG HEAD NECK, V134, P830, DOI 10.1016/j.otohns.2005.12.030 Davis MV, 2007, ANN OTO RHINOL LARYN, V116, P643 Haapaniemi JJ, 2001, DYSPHAGIA, V16, P171, DOI 10.1007/s00455-001-0059-7 Kelly JR, 1997, OP TECH OTOLLARYNGOL, V8, P193, DOI 10.1016/S1043-1810(97)80030-9 Kim DY, 2006, ARCH PHYS MED REHAB, V87, P1346, DOI 10.1016/j.apmr.2006.06.018 Krause E, 2008, DYSPHAGIA, V23, P406, DOI 10.1007/s00455-007-9132-1 Liu LWC, 2004, CAN J GASTROENTEROL, V18, P397 Masiero S, 2006, J REHABIL MED, V38, P201, DOI 10.1080/16501970500515840 MCKENNA JA, 1992, ANN OTO RHINOL LARYN, V101, P216 Merati AL, 2007, ANN OTO RHINOL LARYN, V116, P375 Moerman M, 2002, EUR ARCH OTO-RHINO-L, V259, P1, DOI 10.1007/PL00007520 Moerman Mieke B J, 2006, Curr Opin Otolaryngol Head Neck Surg, V14, P431, DOI 10.1097/MOO.0b013e328010b85b Murry T, 2005, AM J OTOLARYNG, V26, P157, DOI 10.1016/j.amjoto.2004.11.010 Parameswaran MS, 2002, ANN OTO RHINOL LARYN, V111, P871 Restivo DA, 2006, DIABETES CARE, V29, P2650, DOI 10.2337/dc05-2486 Restivo DA, 2011, EUR J NEUROL, V18, P486, DOI 10.1111/j.1468-1331.2010.03189.x SCHNEIDER I, 1994, ANN OTO RHINOL LARYN, V103, P31 Schulze SL, 2002, ANN OTO RHINOL LARYN, V111, P573 Shaw GY, 2001, DYSPHAGIA, V16, P161, DOI 10.1007/s00455-001-0074-8 Sivarao D. V., 2000, American Journal of Medicine, V108, p27S Suzukia Y, 2007, BRAIN DEV-JPN, V29, P662, DOI 10.1016/j.braindev.2007.04.003 Zaninotto G, 2004, J GASTROINTEST SURG, V8, P997, DOI 10.1016/j.gassur.2004.09.037 NR 30 TC 2 Z9 2 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD FEB PY 2013 VL 122 IS 2 BP 100 EP 108 PG 9 WC Otorhinolaryngology SC Otorhinolaryngology GA 200TP UT WOS:000323094100005 PM 23534124 ER PT J AU Torretta, S Drago, L Marchisio, P Gaffuri, M Clemente, IA Pignataro, L AF Torretta, Sara Drago, Lorenzo Marchisio, Paola Gaffuri, Michele Clemente, Ignazio Alessandro Pignataro, Lorenzo TI Topographic Distribution of Biofilm-Producing Bacteria in Adenoid Subsites of Children With Chronic or Recurrent Middle Ear Infections SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE adenoid; biofilm; otitis media with effusion; otopathogen; recurrent acute otitis media ID ACUTE OTITIS-MEDIA; NASOPHARYNGEAL; MANAGEMENT; MODEL AB Objectives: Bacterial biofilms have been found in the adenoids of children with recurrent acute otitis media (AOM) and persistent otitis media with effusion (OME). However, the possible difference in biofilm-producing bacteria (BPBs) between the adenoid surface at the nasopharyngeal dome (ND) and near the ostium of the eustachian tube (ET) has not been investigated. This study aimed to assess the difference in BPBs between adenoid biopsy specimens of the ND and those taken near the pharyngeal ostium of the ET in children with chronic adenoiditis with recurrent AOM and/or persistent OME. Methods: We collected adenoid biopsy specimens from the ND and ET during transoral endoscopic adenoidectomy to assess BPB by means of spectrophotometric analysis. Results: We collected 135 adenoid biopsy specimens from 45 children. BPBs were detected significantly (p = 0.04) more frequently in the ET samples than in the ND samples, mainly Staphylococcus aureus. Although the prevalence of S aureus was slightly greater in the ND samples, and that of Streptococcus pneumoniae and Moraxella catarrhalis was slightly greater in the ET samples, these differences were not statistically significant. Conclusions: The fact that BPBs were significantly more frequently located near the ostium of the ET suggests that the adenoids are a reservoir for bacteria and indicates that hypertrophic adenoids (particularly hypertrophy near the ostium of the ET) play a role in recurrent AOM and/or OME. C1 [Torretta, Sara; Gaffuri, Michele; Clemente, Ignazio Alessandro; Pignataro, Lorenzo] Univ Milan, Dept Clin Sci & Community Hlth, Milan, Italy. [Marchisio, Paola] Univ Milan, Dept Physiopathol & Transplantat, Milan, Italy. [Drago, Lorenzo] Univ Milan, Fdn IRCCS Ca Granda Osped Maggiore Policlin, LITA Clin Microbiol Lab, L Sacco Dept Biomed Sci Hlth, Milan, Italy. [Drago, Lorenzo] Univ Milan, Clin Chem & Microbiol Lab, IRCCS, Galeazzi Inst, Milan, Italy. RP Torretta, S (reprint author), Univ Milan, Fdn IRCCS Ca Granda Osped Maggiore Policlin, Dept Clin Sci & Community Hlth, Via F Sforza 35, I-20122 Milan, Italy. CR Rosenfeld RM, 2004, PEDIATRICS, V113, P1412 Lieberthal AS, 2004, PEDIATRICS, V113, P1451 Cassano P, 2003, INT J PEDIATR OTORHI, V67, P1303, DOI 10.1016/j.ijporl.2003.07.018 CHRISTENSEN GD, 1985, J CLIN MICROBIOL, V22, P996 Donlan RM, 2002, EMERG INFECT DIS, V8, P881 Hall-Stoodley L, 2006, JAMA-J AM MED ASSOC, V296, P202, DOI 10.1001/jama.296.2.202 Hoa M, 2009, INT J PEDIATR OTORHI, V73, P1242, DOI 10.1016/j.ijporl.2009.05.016 Hoa M, 2009, ANN OTO RHINOL LARYN, V118, P292 Homoe P, 2009, EUR ARCH OTO-RHINO-L, V266, P1533, DOI 10.1007/s00405-009-0940-9 Liu YCC, 2009, CURR ALLERGY ASTHM R, V9, P449, DOI 10.1007/s11882-009-0066-6 Marseglia GL, 2009, CURR ALLERGY ASTHM R, V9, P460, DOI 10.1007/s11882-009-0068-4 Marseglia G L, 2011, Int J Immunopathol Pharmacol, V24, P1 Nistico L, 2011, J CLIN MICROBIOL, V49, P1411, DOI 10.1128/JCM.00756-10 Post J Christopher, 2004, Curr Opin Otolaryngol Head Neck Surg, V12, P185, DOI 10.1097/01.moo.0000124936.46948.6a Post J Christopher, 2007, Curr Opin Otolaryngol Head Neck Surg, V15, P347, DOI 10.1097/MOO.0b013e3282b97327 Potera C, 1999, SCIENCE, V283, P1837, DOI 10.1126/science.283.5409.1837 Reid SD, 2009, J INFECT DIS, V199, P786, DOI 10.1086/597042 Starner TD, 2006, AM J RESP CRIT CARE, V174, P213, DOI 10.1164/rccm.200509-1459OC Stepanovic S, 2000, J MICROBIOL METH, V40, P175, DOI 10.1016/S0167-7012(00)00122-6 Stewart PS, 2001, LANCET, V358, P135, DOI 10.1016/S0140-6736(01)05321-1 Torretta S, 2012, OTOLARYNG HEAD NECK, V146, P991, DOI 10.1177/0194599812438169 Torretta S, 2011, OTOLARYNG HEAD NECK, V144, P784, DOI 10.1177/0194599810394955 Zuliani G, 2009, ANN OTO RHINOL LARYN, V118, P519 NR 23 TC 5 Z9 5 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD FEB PY 2013 VL 122 IS 2 BP 109 EP 113 PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA 200TP UT WOS:000323094100006 PM 23534125 ER PT J AU He, XY Cao, JP Shi, XY Zhang, H AF He, Xing-Ying Cao, Jian-Ping Shi, Xue-Yin Zhang, Hao TI Dexmedetomidine Versus Morphine or Fentanyl in the Management of Children After Tonsillectomy and Adenoidectomy: A Meta-analysis of Randomized Controlled Trials SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE dexmedetomidine; fentanyl; meta-analysis; morphine ID OBSTRUCTIVE SLEEP-APNEA; EMERGENCE AGITATION; RECURRENT HYPOXEMIA; OPIOID REQUIREMENT; ANALGESIA; SEDATION; CARE; ADENOTONSILLECTOMY; ANESTHESIA; BEHAVIOR AB Objectives: The primary objective of this review was to evaluate and compare the efficacy and safety of dexmedetomidine hydrochloride with the efficacy and safety of opioids for postoperative management of children after tonsillectomy and adenoidectomy. Methods: We searched the Cochrane Central Register of Controlled Trials (Central) in the Cochrane Library (most recent issue), Medline (1966 to date) through Ovid, Embase (1980 to date), and Web of Science (1945 to date). The number of patients who required rescue analgesics (morphine or fentanyl) in the postanesthesia care unit, the number of patients with emergence agitation, the number of patients with postoperative nausea and vomiting, the time to eye-opening in response to verbal stimuli, and the time to extubation were analyzed. Results: We included 5 trials, consisting of 482 patients in total. There were no significant differences in the number of patients who required rescue analgesics in the postanesthesia care unit, the number of patients with emergence agitation, the number of patients with postoperative nausea and vomiting, or the time to extubation between patients who received dexmedetomidine and those who received opioids. Compared with opioids, dexmedetomidine was associated with a significantly decreased time to eye-opening in response to verbal stimuli (mean difference, -2.11 minutes; 95% confidence interval, -3.32 to -0.91 minutes; p = 0.0006). Conclusions: Intraoperative use of dexmedetomidine was as effective as opioids in preventing postoperative pain and emergence agitation in children who had undergone tonsillectomy and adenoidectomy. C1 [He, Xing-Ying; Shi, Xue-Yin; Zhang, Hao] Second Mil Med Univ, Changzheng Hosp, Dept Anesthesiol, Shanghai, Peoples R China. [Cao, Jian-Ping] PLA 455 Hosp, Dept Anesthesiol, Shanghai, Peoples R China. RP Shi, XY (reprint author), Changzheng Hosp, Dept Anesthesiol, Fengyang Rd 415, Shanghai 200003, Peoples R China. FU National Natural and Scientific Foundation of China [81100049] FX This research was funded by the National Natural and Scientific Foundation of China (81100049). CR Brown KA, 2006, ANESTHESIOLOGY, V105, P665, DOI 10.1097/00000542-200610000-00009 Brown KA, 2004, ANESTHESIOLOGY, V100, P806, DOI 10.1097/00000542-200404000-00009 Cole JW, 2002, PAEDIATR ANAESTH, V12, P442, DOI 10.1046/j.1460-9592.2002.00868.x Coursin D B, 2001, Curr Opin Crit Care, V7, P221, DOI 10.1097/00075198-200108000-00002 Erdil F, 2009, ANAESTH INTENS CARE, V37, P571 Gerlach AT, 2007, ANN PHARMACOTHER, V41, P245, DOI 10.1346/aph.1H314 Guler G, 2005, PEDIATR ANESTH, V15, P762, DOI 10.1111/j.1460-9592.2004.01541.x Hall JE, 2000, ANESTH ANALG, V90, P699, DOI 10.1097/00000539-200003000-00035 Higgins JPT, 2011, COCHRANE HDB SYSTEMA Juni P, 2001, BRIT MED J, V323, P42, DOI 10.1136/bmj.323.7303.42 Lubisch N, 2009, PEDIATR NEUROL, V41, P88, DOI 10.1016/j.pediatrneurol.2009.02.006 Mason KP, 2008, PEDIATR ANESTH, V18, P393, DOI 10.1111/j.1460-9592.2008.02451.x Moiniche S, 2003, ANESTH ANALG, V96, P68, DOI 10.1213/01.ANE.0000040583.65135.57 Olutoye O, 2007, PEDIATR ANESTH, V17, P1007, DOI 10.1111/j.1460-9592.2007.02234.x Olutoye OA, 2010, ANESTH ANALG, V111, P490, DOI 10.1213/ANE.0b013e3181e33429 Patel A, 2010, ANESTH ANALG, V111, P1004, DOI 10.1213/ANE.0b013e3181ee82fa Pestieau SR, 2011, CAN J ANESTH, V58, P540, DOI 10.1007/s12630-011-9493-7 Petroz GC, 2006, ANESTHESIOLOGY, V105, P1098, DOI 10.1097/00000542-200612000-00009 Shukry M, 2005, PEDIATR ANESTH, V15, P1098, DOI 10.1111/j.1460-9592.2005.01660.x Venn RM, 2000, CRIT CARE, V4, P302, DOI 10.1186/cc712 Voepel-Lewis T, 2003, ANESTH ANALG, V96, P1625, DOI 10.1213/01.ANE.0000062522.21048.61 Zhuang PJ, 2011, ANAESTHESIA, V66, P989, DOI 10.1111/j.1365-2044.2011.06817.x NR 22 TC 1 Z9 2 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD FEB PY 2013 VL 122 IS 2 BP 114 EP 120 PG 7 WC Otorhinolaryngology SC Otorhinolaryngology GA 200TP UT WOS:000323094100007 PM 23534126 ER PT J AU Kim, YM Yi, TG Choi, JS Lee, SY Jang, YH Kim, CH Song, SU Lim, JY AF Kim, Young-Mo Yi, TacGhee Choi, Jeong-Seok Lee, Songyi Jang, Yun Ho Kim, Chul-Ho Song, Sun U. Lim, Jae-Yol TI Bone Marrow-Derived Clonal Mesenchymal Stem Cells as a Source of Cell Therapy for Promoting Vocal Fold Wound Healing SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE clonal stem cell; mesenchymal stem cell; scarring; stem cell transplantation; vocal fold; wound healing ID MATRIX GENE-EXPRESSION; STROMAL CELLS; TISSUE-REPAIR; RABBIT MODEL; CANINE MODEL; DIFFERENTIATION; REGENERATION; INJECTION AB Objectives: We investigated whether mouse bone marrow-derived clonal mesenchymal stem cells (BM-cMSCs) could promote vocal fold (VF) wound healing by using a xenograft animal model. Methods: Homogeneous BM-cMSCs isolated by a subfractionation culturing method from the bone marrow aspirates of green fluorescent protein transgenic mice were injected into the VFs of rabbits immediately after direct mechanical injury. Macroscopic, biomechanical (rheometric), histologic, immunohistochemical, and transcriptional evaluations were performed on the scarred VFs 1 to 3 months after injury. Engraftment of the implanted BM-cMSCs was determined by detection of green fluorescent protein cells in the recipient VF by confocal microscopy. Results: The BM-cMSC-treated VFs showed improved morphological properties and viscoelasticity as compared to control VFs injected with phosphate-buffered saline solution. Histologic and immunohistochemical evaluations showed less excessive collagen deposition and increased density of glycosaminoglycans in the BM-cMSC-treated VFs as compared to the control VFs at 3 months after injury (p = 0.003 and p = 0.037, respectively). BM-cMSC transplantation led to a significant attenuation of fibronectin (p = 0.036) and transforming growth factor beta 1 (p = 0.042) messenger RNA expression at 1 month after injury. Green fluorescent protein expressing BM-cMSCs engrafted in recipient VFs were found at 1 month after implantation. Conclusions: BM-cMSCs appeared to survive in the injured xenogeneic VFs after transplantation for up to 1 month and favorably enhanced the wound healing of VFs after injury. We conclude that BM-cMSCs are a possible source of cell therapy for vocal fold regeneration. C1 [Kim, Young-Mo; Yi, TacGhee; Choi, Jeong-Seok; Lee, Songyi; Jang, Yun Ho; Kim, Chul-Ho] Inha Univ, Sch Med, Dept Otorhinolaryngol Head & Neck Surg, Inchon 400711, South Korea. [Kim, Young-Mo; Yi, TacGhee; Choi, Jeong-Seok; Lee, Songyi; Jang, Yun Ho; Song, Sun U.; Lim, Jae-Yol] Inha Univ, Sch Med, Clin Res Ctr, Inchon 400711, South Korea. [Yi, TacGhee; Song, Sun U.] Inha Univ, Sch Med, Inha Res Inst Med Sci, Inchon 400711, South Korea. [Kim, Chul-Ho] Ajou Univ, Sch Med, Dept Otorhinolaryngol, Suwon, South Korea. RP Lim, JY (reprint author), Inha Univ, Sch Med, Dept Otorhinolaryngol Head & Neck Surg, 3-Ga Shinheung Dong, Inchon 400711, South Korea. FU Basic Science Research Program of the National Research Foundation (NRF); Korean Ministry of Education, Science and Technology [2011-0005812]; Inha University Research Grant; Bio & Medical Technology Development Program of the National Research Foundation of the Korean government (MEST) [2011-0019634] FX This study was supported by the Basic Science Research Program of the National Research Foundation (NRF) funded by the Korean Ministry of Education, Science and Technology (grant 2011-0005812) and by an Inha University Research Grant. This study was also supported by the Bio & Medical Technology Development Program (2011-0019634) of the National Research Foundation of the Korean government (MEST). Authors Y.-M. Kim and Yi contributed equally to this study, as did authors Song and Lim CR Ball L, 2008, LEUKEMIA, V22, P1256, DOI 10.1038/sj.leu.2405013 Benninger MS, 1996, OTOLARYNG HEAD NECK, V115, P474, DOI 10.1016/S0194-5998(96)70087-6 Clark BR, 1995, ANN NY ACAD SCI, V770, P70, DOI 10.1111/j.1749-6632.1995.tb31044.x Hanson SE, 2010, CURR STEM CELL RES T, V5, P268 Hertegard S, 2006, LARYNGOSCOPE, V116, P1248, DOI 10.1097/01.mlg.0000224548.68499.35 Hirano S, 2003, LARYNGOSCOPE, V113, P966, DOI 10.1097/00005537-200306000-00010 Johnson BQ, 2010, LARYNGOSCOPE, V120, P537, DOI 10.1002/lary.20782 Kanemaru S, 2005, ANN OTO RHINOL LARYN, V114, P907 Kanemaru SI, 2003, ANN OTO RHINOL LARYN, V112, P915 Kumai Y, 2009, LARYNGOSCOPE, V119, P799, DOI 10.1002/lary.20149 Kutty JK, 2009, TISSUE ENG PART B-RE, V15, P249, DOI 10.1089/ten.TEB.2008.0588 Liechty KW, 2000, NAT MED, V6, P1282 Long JL, 2010, CURR OPIN OTOLARYNGO, V18, P521, DOI 10.1097/MOO.0b013e32833febf2 Ohno S, 2011, ANN OTO RHINOL LARYN, V120, P401 Ohno T, 2009, OTOLARYNG HEAD NECK, V140, P757, DOI 10.1016/j.otohns.2008.12.065 Ohno T, 2009, LARYNGOSCOPE, V119, P806, DOI 10.1002/lary.20174 Pittenger MF, 1999, SCIENCE, V284, P143, DOI 10.1126/science.284.5411.143 Prockop DJ, 2007, BLOOD, V109, P3147, DOI 10.1182/blood-2006-03-013433 Rickard DJ, 1996, J BONE MINER RES, V11, P312 Rousseau B, 2003, LARYNGOSCOPE, V113, P620, DOI 10.1097/00005537-200304000-00007 Rousseau B, 2004, J VOICE, V18, P116, DOI 10.1016/j.jvoice.2003.06.001 Rousseau B, 2008, ANN OTO RHINOL LARYN, V117, P598 Song SU, 2008, STEM CELLS DEV, V17, P451, DOI 10.1089/scd.2007.0167 Svensson B, 2010, LARYNGOSCOPE, V120, P1370, DOI 10.1002/lary.20926 Tateya T, 2005, ANN OTO RHINOL LARYN, V114, P183 Wu YJ, 2007, STEM CELLS, V25, P2648, DOI 10.1634/stemcells.2007-0226 NR 26 TC 4 Z9 4 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD FEB PY 2013 VL 122 IS 2 BP 121 EP 130 PG 10 WC Otorhinolaryngology SC Otorhinolaryngology GA 200TP UT WOS:000323094100008 PM 23534127 ER PT J AU Cho, CH Jung, BS Jung, JH Lee, JH Lee, JH AF Cho, Chang Hyun Jung, Byoung Seo Jung, Joo Hyun Lee, Jung Ho Lee, Ju Hyoung TI Expression of Autoantibodies in Patients With Sudden Sensorineural Hearing Loss SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE autoantibody; corticosteroid; sudden sensorineural hearing loss ID INNER-EAR DISEASE; MENIERES-DISEASE; AUTOANTIGEN; DISORDERS AB Objectives: The aim of this study was to establish the expression rate of autoimmunity in patients with sudden sensorineural hearing loss and to determine whether a positive marker is associated with a higher rate of hearing recovery after steroid treatment. Methods: A prospective study was performed on 137 patients who experienced sudden sensorineural hearing loss and underwent immunoserologic investigations. Autoantibodies evaluated on the day of admission included anti-double-stranded DNA, rheumatoid factor, antiphospholipid immunoglobulins G and M, antinuclear antibody, and complements C3 and C4. Results: Of 137 patients, 75 were male and 62 were female (mean age, 45.1 years). Hearing loss was found on the left side in 61 patients and on the right side in 76 patients. Elevation of at least 1 autoantibody or abnormal complement levels were found in 80 patients (58%), and abnormalities of 2 or more antibodies were found in 28 (20%). There were no statistically significant correlations between autoantibody abnormalities and age, initial hearing level, or positive treatment response. Conclusions: There is no clear evidence of a correlation between autoimmunity and hearing improvement in patients with autoantibody abnormalities. A high (but not significant) expression rate of autoantibody abnormality and complement level was seen in patients with sudden sensorineural hearing loss. C1 [Cho, Chang Hyun; Jung, Byoung Seo; Jung, Joo Hyun; Lee, Jung Ho; Lee, Ju Hyoung] Gachon Univ Med & Sci, Grad Sch Med, Dept Otorhinolaryngol Head & Neck Surg, Inchon 405760, South Korea. RP Lee, JH (reprint author), Gachon Univ Med & Sci, Grad Sch Med, Dept Otorhinolaryngol Head & Neck Surg, 1198 Guwol Dong, Inchon 405760, South Korea. FU Gil Hospital, Gachon University of Medicine and Science, Graduate School of Medicine FX This study was supported by a grant from the Gil Hospital, Gachon University of Medicine and Science, Graduate School of Medicine. CR Agrup C, 2006, CURR OPIN NEUROL, V19, P26 Agrup C, 2008, INT J AUDIOL, V47, P560, DOI 10.1080/14992020802282268 Alexander TH, 2009, OTOL NEUROTOL, V30, P443, DOI 10.1097/MAO.0b013e3181a52773 Berrettini S, 1998, Acta Otorhinolaryngol Ital, V18, P33 Boulassel MR, 2000, CLIN OTOLARYNGOL, V25, P535, DOI 10.1046/j.1365-2273.2000.00416.x Cheng KC, 2000, ANN OTO RHINOL LARYN, V109, P1093 Compadretti GC, 2005, ANN OTO RHINOL LARYN, V114, P214 Hervier B, 2010, OTOL NEUROTOL, V31, P687, DOI 10.1097/MAO.0b013e3181dd13cc Kim HJ, 1998, KOREAN J OTOLARYNGOL, V41, P976 LEHNHARDT E, 1958, Z Laryngol Rhinol Otol, V37, P1 MCCABE BF, 1979, ANN OTO RHINOL LARYN, V88, P585 Park KY, 1997, KOREAN J OTOLOARYNGO, V40, P725 Park SN, 2000, KOREAN J OTOLARYNGOL, V43, P663 Passali D, 2004, ACTA OTO-LARYNGOL, V124, P1145, DOI 10.1080/00016480410017873 Ruckenstein MJ, 2002, OTOL NEUROTOL, V23, P517, DOI 10.1097/00129492-200207000-00021 Stew BT, 2012, BRIT J HOSP MED, V73, P86 Trune DR, 2010, J NEUROIMMUNOL, V229, P140, DOI 10.1016/j.jneuroim.2010.07.026 Yeo SW, 1997, KOREAN J OTOLARYNGOL, V40, P1181 Yoo TJ, 2003, INT C SERIES, V1240, P1207, DOI 10.1016/S0531-5131(03)00814-8 NR 19 TC 0 Z9 0 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD FEB PY 2013 VL 122 IS 2 BP 131 EP 134 PG 4 WC Otorhinolaryngology SC Otorhinolaryngology GA 200TP UT WOS:000323094100009 PM 23534128 ER PT J AU Julias, M Riede, T Cook, D AF Julias, Margaret Riede, Tobias Cook, Douglas TI Visualizing Collagen Network Within Human and Rhesus Monkey Vocal Folds Using Polarized Light Microscopy SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE collagen fiber; fiber orientation; lamina propria ID LAMINA PROPRIA; ARTICULAR-CARTILAGE; FIBERS; TISSUE; BIREFRINGENCE; ELASTICITY AB Objectives: Collagen fiber content and orientation affect the viscoelastic properties of the vocal folds, determining oscillation characteristics during speech and other vocalization. The investigation and reconstruction of the collagen network in vocal folds remains a challenge, because the collagen network requires at least micron-scale resolution. In this study, we used polarized light microscopy to investigate the distribution and alignment of collagen fibers within the vocal folds. Methods: Data were collected in sections of human and rhesus monkey (Macaca mulatta) vocal folds cut at 3 different angles and stained with picrosirius red. Results: Statistically significant differences were found between different section angles, implying that more than one section angle is required to capture the network's complexity. In the human vocal folds, the collagen fiber distribution continuously varied across the lamina propria (medial to lateral). Distinct differences in birefringence distribution were observed between the species. For the human vocal folds, high birefringence was observed near the thyroarytenoid muscle and near the epithelium. However, in the rhesus monkey vocal folds, high birefringence was observed near the epithelium, and lower birefringence was seen near the thyroarytenoid muscle. Conclusions: The differences between the collagen networks in human and rhesus monkey vocal folds provide a morphological basis for differences in viscoelastic properties between species. C1 [Julias, Margaret; Cook, Douglas] NYU, Div Engn, Abu Dhabi, U Arab Emirates. [Riede, Tobias] Univ Utah, Dept Biol, Salt Lake City, UT 84112 USA. [Riede, Tobias] Univ Utah, Natl Ctr Voice & Speech, Salt Lake City, UT USA. RP Julias, M (reprint author), POB 129188, Abu Dhabi, U Arab Emirates. FU National Institutes of Health [R01 DC008612, R01 DC04390, 5 U42 RR006042]; National Center for Research Resources, a component of the National Institutes of Health [P51 RR000167] FX Funding for this work was provided in part by National Institutes of Health grants R01 DC008612 (A Simulator for Sound Production in Airways; principal investigator, Ingo R. Titze) and R01 DC04390. This publication was also made possible in part by grant P51 RR000167 from the National Center for Research Resources, a component of the National Institutes of Health, to the Wisconsin National Primate Research Center, University of Wisconsin-Madison. Use of human tissues was provided by the National Disease Research Interchange, with support from National Institutes of Health grant 5 U42 RR006042. CR Berens P, 2009, J STAT SOFTW, V31, P1 BULLOUGH P, 1968, Journal of Bone and Joint Surgery British Volume, V50-B, P852 Chan RW, 2007, ANN BIOMED ENG, V35, P1471, DOI 10.1007/s10439-007-9314-x de Melo ECM, 2003, LARYNGOSCOPE, V113, P2187 Glazer AM, 1996, P ROY SOC A-MATH PHY, V452, P2751, DOI 10.1098/rspa.1996.0145 Gray SD, 2000, ANN OTO RHINOL LARYN, V109, P77 Hammond TH, 1998, OTOLARYNG HEAD NECK, V119, P314, DOI 10.1016/S0194-5998(98)70071-3 Hammond TH, 2000, ANN OTO RHINOL LARYN, V109, P913 Hirano M., 1975, OTOLOGIA FUKUOKA S1, V21, P239 Hirano M., 1982, SPEECH LANG, V7, P271 HIRANO M, 1989, ACTA OTO-LARYNGOL, V107, P428, DOI 10.3109/00016488909127535 Ishii K, 2000, ANN OTO RHINOL LARYN, V109, P1055 Jin LW, 2003, P NATL ACAD SCI USA, V100, P15294, DOI 10.1073/pnas.2534647100 JUNQUEIRA LCU, 1982, HISTOCHEMISTRY, V74, P153, DOI 10.1007/BF00495061 Kiraly K, 1997, HISTOCHEM J, V29, P317, DOI 10.1023/A:1020802631968 Klemuk SA, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0027029 Krausert CR, 2011, J VOICE, V25, P395, DOI 10.1016/j.jvoice.2010.02.001 Kurita S., 1983, VOCAL FOLD PHYSL CON, P3 Munoz-Pinto D, 2009, ANN OTO RHINOL LARYN, V118, P299 Prades JM, 2010, SURG RADIOL ANAT, V32, P377, DOI 10.1007/s00276-009-0577-9 Riede T, 2010, J EXP BIOL, V213, P2924, DOI 10.1242/jeb.044404 Riede T, 2010, J MORPHOL, V271, P1, DOI 10.1002/jmor.10774 Roberts T, 2011, CLIN ANAT, V24, P544, DOI 10.1002/ca.21114 Sakae FA, 2008, LARYNGOSCOPE, V118, P1500, DOI 10.1097/MLG.0b013e3181770955 Sato K, 2002, ANN OTO RHINOL LARYN, V111, P15 Sato K, 2012, J VOICE, V26, P37, DOI 10.1016/j.jvoice.2010.10.006 SPEER DP, 1979, CLIN ORTHOP RELAT R, P267 WHITTAKER P, 1989, AM HEART J, V118, P341, DOI 10.1016/0002-8703(89)90195-6 NR 28 TC 1 Z9 1 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD FEB PY 2013 VL 122 IS 2 BP 135 EP 144 PG 10 WC Otorhinolaryngology SC Otorhinolaryngology GA 200TP UT WOS:000323094100010 PM 23534129 ER PT J AU Ledgerwood, LG Salgado, MD Black, H Yoneda, K Sievers, A Belafsky, PC AF Ledgerwood, Levi G. Salgado, Moses D. Black, Hugh Yoneda, Ken Sievers, Ann Belafsky, Peter C. TI Tracheotomy Tubes With Suction Above the Cuff Reduce the Rate of Ventilator-Associated Pneumonia in Intensive Care Unit Patients SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article; Proceedings Paper CT Meeting of the American-Broncho-Esophagological-Association CY APR 18-19, 2012 CL San Diego, CA SP Amer Broncho Esophagol Assoc DE subglottic suction; tracheotomy; ventilator-associated pneumonia ID RANDOMIZED CLINICAL-TRIAL; SUBGLOTTIC SECRETION DRAINAGE; CONTINUOUS ASPIRATION; PULMONARY ASPIRATION; INTUBATED PATIENTS; PREVENTION; TRACHEOSTOMIES; VOLUME AB Objectives: We evaluated the effect of tracheotomy tubes that enable suction immediately above the cuff on the development of ventilator-associated pneumonia (VAP). Methods: Patients without preexisting pneumonia who required tracheotomy were randomly assigned to receive a tracheotomy tube with or without above-the-cuff suction. The suction tube provided 10 mm Hg of continuous wall suction while the tracheotomy tube cuff was inflated. Data regarding the development of VAP, time on the ventilator, and length of stay in the intensive care unit (ICU) were recorded and compared between groups. Results: Eighteen patients were randomized and prospectively evaluated. Nine patients received standard tracheotomy tubes, and 9 received suction-above-the-cuff tracheotomy tubes. The prevalences of VAP were 56% in the control group and 11% in the suction tracheotomy group (p = 0.02). The mean times on the ventilator were 18 +/- 14 days in the control group and 11 +/- 11 days in the suction group (p = 0.12). The mean lengths of ICU stay were 26 +/- 15 days in the control group and 18 +/- 15 days in the suction group (p = 0.14). Conclusions: Use of suction-above-the-cuff tracheotomy tubes significantly decreases the incidence of VAP in ICU patients. There were trends toward decreased time on the ventilator and decreased length of stay in the ICU. C1 [Ledgerwood, Levi G.; Salgado, Moses D.; Sievers, Ann; Belafsky, Peter C.] Univ Calif Davis, Dept Otolaryngol Head & Neck Surg, Ctr Voice & Swallowing, Sacramento, CA 95817 USA. [Black, Hugh; Yoneda, Ken] Univ Calif Davis, Dept Pulm & Crit Care Med, Sacramento, CA 95817 USA. RP Belafsky, PC (reprint author), Univ Calif Davis, Dept Otolaryngol Head & Neck Surg, Ctr Voice & Swallowing, 2521 Stockton Blvd,Suite 7200, Sacramento, CA 95817 USA. CR Berra L, 2004, CRIT CARE MED, V32, P2071, DOI 10.1097/01.CCM.0000142575.86468.98 Blunt MC, 2001, ANESTHESIOLOGY, V95, P377, DOI 10.1097/00000542-200108000-00019 Bonten MJM, 2011, CLIN INFECT DIS, V52, P115, DOI 10.1093/cid/ciq075 CAMERON JL, 1973, SURG GYNECOL OBSTET, V136, P68 Cocanour Christine S, 2005, Surg Infect (Larchmt), V6, P65, DOI 10.1089/sur.2005.6.65 Coffman HMS, 2008, OTOLARYNG HEAD NECK, V138, P441, DOI 10.1016/j.otohns.2007.11.013 ELPERN EH, 1994, CHEST, V105, P563, DOI 10.1378/chest.105.2.563 Falagas ME, 2012, CLIN INFECT DIS, V54, P681, DOI 10.1093/cid/cir931 Garcia-Leoni ME, 2010, SPINAL CORD, V48, P876, DOI 10.1038/sc.2010.43 Girou E, 2004, INTENS CARE MED, V30, P225, DOI 10.1007/s00134-003-2077-4 Higgins DM, 1997, HEART LUNG, V26, P215, DOI 10.1016/S0147-9563(97)90058-3 Kollef MH, 2012, INFECT CONT HOSP EP, V33, P250, DOI 10.1086/664049 Kollef MH, 1999, CHEST, V116, P1339, DOI 10.1378/chest.116.5.1339 Kornblith LZ, 2011, J AM COLL SURGEONS, V212, P163, DOI 10.1016/j.jamcollsurg.2010.09.024 Leasure A Renee, 2012, Dimens Crit Care Nurs, V31, P102, DOI 10.1097/DCC.0b013e3182445ff3 MAHUL P, 1992, INTENS CARE MED, V18, P20, DOI 10.1007/BF01706421 MILLER FR, 1994, AM J OTOLARYNG, V15, P1, DOI 10.1016/0196-0709(94)90034-5 Muscedere J, 2011, CRIT CARE MED, V39, P1985, DOI 10.1097/CCM.0b013e318218a4d9 O'Neal PV, 2007, BIOL RES NURS, V8, P202, DOI 10.1177/1099800406295517 Ozcaka O, 2012, J PERIODONTAL RES, V47, P584, DOI 10.1111/j.1600-0765.2012.01470.x Pugin I, 1991, AM REV RESPIR DIS, V143, P1121 Rello J, 2012, CLIN MICROBIOL INFEC Shorr AF, 2001, CHEST, V119, P228, DOI 10.1378/chest.119.1.228 Smulders K, 2002, CHEST, V121, P858, DOI 10.1378/chest.121.3.858 Sole ML, 2011, AM J CRIT CARE, V20, pE141, DOI 10.4037/ajcc2011178 Tong CCL, 2012, OTOLARYNG HEAD NECK, V147, P44, DOI 10.1177/0194599812440262 VALLES J, 1995, ANN INTERN MED, V122, P179 van Saene HKF, 2004, CRIT CARE MED, V32, P2160, DOI 10.1097/01.CCM.0000142902.24268.CC Vincent JL, 2009, JAMA-J AM MED ASSOC, V302, P2323, DOI 10.1001/jama.2009.1754 NR 29 TC 3 Z9 5 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD JAN PY 2013 VL 122 IS 1 BP 3 EP 8 PG 6 WC Otorhinolaryngology SC Otorhinolaryngology GA 074YQ UT WOS:000313851400002 PM 23472309 ER PT J AU Sung, CK Tsao, GJ AF Sung, C. Kwang Tsao, Gabriel J. TI Single-Operator Flexible Nasolaryngoscopy-Guided Transthyrohyoid Vocal Fold Injections SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article; Proceedings Paper CT Meeting of the American-Broncho-Esophagological-Association CY APR 18-19, 2012 CL San Diego, CA SP Amer Broncho Esophagol Assoc DE cidofovir; injection laryngoplasty; in-office procedure; steroid; thyrohyoid approach; vocal fold injection ID THYROHYOID APPROACH AB Objectives: A number of laryngeal injection techniques have been described for performing vocal fold medialization or delivery of medications, including peroral and percutaneous approaches. Although flexible nasolaryngoscopy-guided injection (FNGI) improves visualization and patient tolerance over rigid endoscopy, the technique requires an assistant to manipulate the laryngoscope. The efficacy and patient tolerance of a novel, single-operator technique for FNGI are evaluated. Methods: Patients who required laryngeal injection for vocal fold medialization or for administration of cidofovir or steroids were included in this study. Indications included vocal fold paresis or paralysis, sulcus deformities, recurrent respiratory papillomatosis, vocal fold polyps, and laryngeal granulomas. All procedures were performed in the office setting with topical and local anesthesia with the patient awake. The surgeon performed flexible nasolaryngoscopy with the nondominant hand while using the dominant hand to perform transthyrohyoid injection with a 25-gauge needle with proximal and distal bends. Results: Twenty-six patients underwent a total of 42 single-operator FNGI procedures; 19 unilateral and 23 bilateral injections were performed. All but 1 of the procedures were completed with adequate visualization and placement of injectant and good patient tolerance. Conclusions: Single-operator FNGI via a transthyrohyoid approach is a viable and versatile laryngeal injection technique for a variety of indications. It provides access to the anterior, middle, and posterior parts of the larynx. It eliminates the need for an assistant experienced in nasolaryngoscopy and allows the surgeon to adjust and optimize visualization in a fashion analogous to endoscopic sinus surgery. C1 [Sung, C. Kwang] Stanford Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, Div Laryngol, Stanford, CA 94305 USA. Vet Affairs Palo Alto Hlth Care Syst, Surg Serv, Div Otolaryngol, Palo Alto, CA USA. RP Sung, CK (reprint author), Stanford Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, Div Laryngol, 801 Welch Rd, Stanford, CA 94305 USA. CR Achkar J, 2012, LARYNGOSCOPE, V122, P865, DOI 10.1002/lary.22181 Amin MR, 2006, ANN OTO RHINOL LARYN, V115, P699 ARNOLD GE, 1955, ARCHIV OTOLARYNGOL, V62, P1 Bruening W., 1911, VERH DTSCH LARYNG, V18, P23 Getz AE, 2005, J VOICE, V19, P501, DOI 10.1016/j.jvoice.2004.07.007 Hoffman HT, 2001, HEAD NECK-J SCI SPEC, V23, P1061, DOI 10.1002/hed.10014 MediGuard, SAF AL CID Mortensen M, 2006, LARYNGOSCOPE, V116, P1735, DOI 10.1097/01.mlg.0000231455.19183.8c Rees CJ, 2006, OTOLARYNG HEAD NECK, V134, P1023, DOI 10.1016/j.otohns.2006.01.019 Woo P, 2006, OTOLARYNG CLIN N AM, V39, P111, DOI 10.1016/j.otc.2005.11.008 Zeitler Daniel M, 2007, Curr Opin Otolaryngol Head Neck Surg, V15, P412, DOI 10.1097/MOO.0b013e3282f033ec NR 11 TC 1 Z9 1 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD JAN PY 2013 VL 122 IS 1 BP 9 EP 14 PG 6 WC Otorhinolaryngology SC Otorhinolaryngology GA 074YQ UT WOS:000313851400003 PM 23472310 ER PT J AU Riffat, F Del Pero, MM Fish, B Jani, P AF Riffat, Faruque Del Pero, Marcos Martinez Fish, Brian Jani, Piyush TI Radiologically Predicting When a Sternotomy May Be Required in the Management of Retrosternal Goiters SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE mediastinum; retrosternal goiter; sternotomy; thyroidectomy ID SUBSTERNAL GOITER; SURGICAL APPROACH; THYROID-CANCER; NEED AB Objectives: Surgery remains the most effective treatment for retrosternal goiters. These commonly present as asymptomatic lesions in elderly patients, but may also cause airway and esophageal compression and, less commonly, may also be malignant. Although the majority of these goiters are amenable to transcervical thyroidectomy, in a minority of patients sternotomy is required. The ability to predict the need for sternotomy before operation would allow for safer surgery and operative counseling, as well as improved logistical efficiency if coordination with thoracic surgeons is required. In this report, we assess the radiologic factors that might be predictive of the need for sternotomy. Methods: We performed a retrospective review of 97 retrosternal goiters for which thyroidectomy was performed within the otolaryngology department at Addenbrooke's Hospital, Cambridge, between 2001 and 2011. There were a total of 80 cervical excisions and 17 cases in which sternotomy was required. A detailed computed tomographic analysis of these 17 cases was undertaken to assess the predictive factors for the requirement of sternotomy. The factors assessed included posterior mediastinal extension, presence of an ectopic nodule, extension below the carina, extension below the aortic arch, a "conical shape" of the goiter, and tracheal compression. These were compared to the same factors in the control group of 80 patients, and Fisher's exact test was used to determine statistical significance. Results: The significant predictive factors for sternotomy were posterior mediastinal extension, extension below the carina, and a "conical" goiter in which the thoracic inlet becomes a ring of constriction (all p < 0.05). Conclusions: Our results suggest that it is possible to predict on the basis of computed tomographic imaging the need for sternotomy in retrosternal goiters. C1 [Riffat, Faruque; Del Pero, Marcos Martinez; Fish, Brian; Jani, Piyush] Addenbrookes Hosp, Dept Otolaryngol Head & Neck Surg, Cambridge CB20QQ, England. RP Riffat, F (reprint author), Addenbrookes Hosp, Dept Otolaryngol Head & Neck Surg, Box 10, Cambridge CB20QQ, England. CR Agha A, 2008, SURG TODAY, V38, P505, DOI 10.1007/s00595-007-3659-5 Burns P, 2008, J LARYNGOL OTOL, V122, P495, DOI 10.1017/S0022215107000047 Casella C, 2010, HEAD NECK-J SCI SPEC, V32, P1131, DOI 10.1002/hed.21303 Cohen JR, 2009, LARYNGOSCOPE, V119, P683, DOI 10.1002/lary.20102 Flati G, 2005, CLIN TER, V156, P191 Hashmi SM, 2006, J LARYNGOL OTOL, V120, P644, DOI 10.1017/S0022215106000995 Hedayati N, 2002, AM SURGEON, V68, P245 Huins Charles T, 2008, Int J Surg, V6, P71, DOI 10.1016/j.ijsu.2007.02.003 Lang BH, 2009, THYROID PARATHYROID, P90 Lola I, 2011, J CARDIOTHORAC SURG, V6, DOI 10.1186/1749-8090-6-151 Machens A, 2009, ANN SURG ONCOL, V16, P171, DOI 10.1245/s10434-008-0201-y Mackle T, 2007, J LARYNGOL OTOL, V121, P358 Mercante G, 2011, HEAD NECK-J SCI SPEC, V33, P792, DOI 10.1002/hed.21539 Moron J C, 1998, Am Surg, V64, P889 Netterville JL, 1998, LARYNGOSCOPE, V108, P1611, DOI 10.1097/00005537-199811000-00005 NEWMAN E, 1995, J SURG ONCOL, V60, P207, DOI 10.1002/jso.2930600313 Ozer MT, 2009, ACTA CHIR BELG, V109, P527 Pai SI, 2008, ORL J OTO-RHINO-LARY, V70, P292, DOI 10.1159/000149831 Raffaelli M, 2011, HEAD NECK-J SCI SPEC, V33, P1420, DOI 10.1002/hed.21617 Rodriguez JM, 1999, ANN OTO RHINOL LARYN, V108, P501 Rugiu MG, 2009, ACTA OTORHINOLARYNGO, V29, P331 SAND ME, 1983, AM SURGEON, V49, P196 Scott-Conner CEH, 2006, CHASSINS OPERATIVE S, P13 Shah Bhavin C, 2007, Ann Thorac Cardiovasc Surg, V13, P122 SHAHA AR, 1989, HEAD NECK-J SCI SPEC, V11, P325, DOI 10.1002/hed.2880110407 Testini M, 2011, ANN SURG ONCOL, V18, P2251, DOI 10.1245/s10434-011-1596-4 White ML, 2008, WORLD J SURG, V32, P1285, DOI 10.1007/s00268-008-9466-3 NR 27 TC 3 Z9 3 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD JAN PY 2013 VL 122 IS 1 BP 15 EP 19 PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA 074YQ UT WOS:000313851400004 PM 23472311 ER PT J AU Stein, DJ Noordzij, JP AF Stein, Daniel J. Noordzij, J. Pieter TI Amitriptyline for Symptomatic Treatment of Idiopathic Chronic Laryngeal Irritability SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE chronic cough; chronic laryngeal irritability; chronic laryngitis; idiopathic laryngitis; irritable larynx; neuropathic cough; vagal neuropathy ID POSTVIRAL VAGAL NEUROPATHY; QUALITY-OF-LIFE; CHRONIC COUGH AB Objectives: We evaluated the safety and efficacy of amitriptyline hydrochloride in treating idiopathic chronic laryngeal irritability. Methods: A retrospective chart review identified patients treated with amitriptyline for laryngeal irritability in an academic otolaryngology practice. Subjects who had documented medication compliance and a follow-up evaluation performed within 3 months after initiation of treatment were included. Symptoms, demographic information, and response to therapy were abstracted from the records. Results: Sixty-six subjects were identified, comprising 48 women and 18 men. The ethnicities were black, 42%; Hispanic, 27%; white, 20%; Asian, 6%; and other or unspecified, 5%. The response to treatment was judged complete in 32% of subjects, partial in 24%, and without improvement in 36%; the remaining 8% were unable to tolerate treatment. Overall, 56.1% of subjects improved (95% confidence limit, 43.3% to 68.3%). No significant differences in response rates were seen based on gender (p = 0.484), age (p = 0.590), or race (p = 0.846). Sedation was reported by 23% of individuals. Conclusions: We found that more than 50% of subjects who received amitriptyline for chronic laryngeal irritability experienced improvement, and most subjects tolerated this treatment. No differences in efficacy were seen among racial, age, and gender subgroups. A prospective randomized trial of this therapy appears warranted. C1 [Noordzij, J. Pieter] Boston Univ, Sch Med, Boston, MA 02118 USA. Boston Med Ctr, Dept Otolaryngol Head & Neck Surg, Boston, MA USA. RP Noordzij, JP (reprint author), 4th Floor,FGH Bldg,820 Harrison Ave, Boston, MA 02118 USA. CR Amin MR, 2001, AM J OTOLARYNG, V22, P251, DOI 10.1053/ajot.2001.24823 Bastian RW, 2006, OTOLARYNG HEAD NECK, V135, P17, DOI 10.1016/j.otohns.2006.02.003 Jeyakumar A, 2006, LARYNGOSCOPE, V116, P2108, DOI 10.1097/01.mlg.0000244377.60334.e3 Koufman J, 2008, VISIBLE VOICE, V2, P7 Krischke S, 2005, J VOICE, V19, P132, DOI 10.1016/j.jvoice.2004.01.007 Lee B, 2005, ANN OTO RHINOL LARYN, V114, P253 Morrison M, 1999, J VOICE, V13, P447, DOI 10.1016/S0892-1997(99)80049-6 Rees CJ, 2009, ANN OTO RHINOL LARYN, V118, P247 Tune LE, 2001, J CLIN PSYCHIAT, V62, P11 Wilson JA, 2002, CLIN OTOLARYNGOL, V27, P179, DOI 10.1046/j.1365-2273.2002.00559.x NR 10 TC 2 Z9 2 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD JAN PY 2013 VL 122 IS 1 BP 20 EP 24 PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA 074YQ UT WOS:000313851400005 PM 23472312 ER PT J AU Otsuki, K Imaizumi, M Nomoto, Y Wada, I Miyake, M Sugino, T Omori, K AF Otsuki, Koshi Imaizumi, Mitsuyoshi Nomoto, Yukio Wada, Ikuo Miyake, Masao Sugino, Takashi Omori, Koichi TI Potential for Respiratory Epithelium Regeneration From Induced Pluripotent Stem Cells SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article; Proceedings Paper CT Meeting of the American-Broncho-Esophagological-Association CY APR 18-19, 2012 CL San Diego, CA SP Amer Broncho Esophagol Assoc DE ciliated cell; induced pluripotent stem cell; knockout serum replacement; respiratory epithelium ID MOUSE ES CELLS; DEFINITIVE ENDODERM; DIFFERENTIATION; INDUCTION; MEDICINE; SIGNALS; CULTURE AB Objectives: In cases of laryngeal inflammatory lesions and tracheal invasion of a malignant tumor, autologous tissue implantation techniques using skin or cartilage are often applied. However, these techniques are both invasive and unstable. The purpose of this study was to evaluate the potential use of induced pluripotent stem (iPS) cells in the regeneration of respiratory epithelium. Methods: We seeded iPS cells on low-attachment plates in serum-free media to generate embryoid bodies (EBs). After a 3-day culture, the EBs were transferred to a gelatin-coated dish supplemented with activin A alone or with basic fibroblast growth factor (induction groups). As a control, EBs were cultured without these growth factors (control group). Cultured tissues from all groups were histologically examined for 2 weeks. Results: In the induction groups, the presence of respiratory epithelium-like tissue was observed with hematoxylin and eosin staining after 14 days of culture. Conclusions: This study demonstrated the potential use of iPS cells in regeneration of the respiratory epithelium. C1 [Otsuki, Koshi] Fukushima Med Univ, Sch Med, Dept Otolaryngol, Fukushima 9601295, Japan. [Wada, Ikuo] Fukushima Med Univ, Inst Biomed Sci, Dept Cell Sci, Fukushima 9601295, Japan. [Miyake, Masao] Fukushima Med Univ, Dept Cellular & Integrat Physiol, Fukushima 9601295, Japan. [Sugino, Takashi] Fukushima Med Univ, Dept Basic Pathol, Fukushima 9601295, Japan. RP Otsuki, K (reprint author), Fukushima Med Univ, Sch Med, Dept Otolaryngol, 1 Hikarigaoka, Fukushima 9601295, Japan. CR Akagi T, 2003, P NATL ACAD SCI USA, V100, P13567, DOI 10.1073/pnas.1834876100 Bauwens CL, 2008, STEM CELLS, V26, P2300, DOI 10.1634/stemcells.2008-0183 Coraux C, 2005, AM J RESP CELL MOL, V32, P87, DOI 10.1165/rcmb.2004-0079RC D'Amour KA, 2005, NAT BIOTECHNOL, V23, P1534, DOI 10.1038/nbt1163 Eiraku M, 2008, CELL STEM CELL, V3, P519, DOI 10.1016/j.stem.2008.09.002 Hatsuzawa K, 2006, MOL BIOL CELL, V17, P3964, DOI 10.1091/mbc.E05-12-1174 Honda M, 2006, BIOCHEM BIOPH RES CO, V351, P877, DOI 10.1016/j.bbrc.2006.10.126 Imaizumi M, 2010, ANN OTO RHINOL LARYN, V119, P697 Macchiarini P, 2009, LANCET, V373, P462 Nakanishi M, 2009, FASEB J, V23, P114, DOI 10.1096/fj.08-111203 Nishimura Y, 2006, STEM CELLS, V24, P1381, DOI 10.1634/stemcells.2005-0464 Okita K, 2007, NATURE, V448, P313, DOI 10.1038/nature05934 Omori K, 2005, ANN OTO RHINOL LARYN, V114, P429 Parker NP, 2009, LARYNGOSCOPE, V119, P734, DOI 10.1002/lary.20131 Presta M, 2005, CYTOKINE GROWTH F R, V16, P159, DOI 10.1016/j.cytogfr.2005.01.004 Samadikuchaksaraei A, 2006, TISSUE ENG, V12, P867, DOI 10.1089/ten.2006.12.867 Shiraki N, 2008, STEM CELLS, V26, P874, DOI [10.1634/stemcells.2007-0608, 10.1634/stemeells.2007-0608] Tada S, 2005, DEVELOPMENT, V132, P4363, DOI 10.1242/dev.02005 Takahashi K, 2006, CELL, V126, P663, DOI 10.1016/j.cell.2006.07.024 Wataya T, 2008, P NATL ACAD SCI USA, V105, P11796, DOI 10.1073/pnas.0803078105 Xu Y, 2008, NATURE, V453, P338, DOI 10.1038/nature07042 Yasunaga M, 2005, NAT BIOTECHNOL, V23, P1542, DOI 10.1038/nbt1167 NR 22 TC 2 Z9 2 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD JAN PY 2013 VL 122 IS 1 BP 25 EP 32 PG 8 WC Otorhinolaryngology SC Otorhinolaryngology GA 074YQ UT WOS:000313851400006 PM 23472313 ER PT J AU Jia, H Wang, J Francois, F Uziel, A Puel, JL Venail, F AF Jia, Huan Wang, Jing Francois, Florence Uziel, Alain Puel, Jean-Luc Venail, Frederic TI Molecular and Cellular Mechanisms of Loss of Residual Hearing After Cochlear Implantation SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE apoptosis; cochlear implantation; fibrosis; necrosis; residual hearing ID NECROSIS-FACTOR-ALPHA; ROUND WINDOW DEXAMETHASONE; INNER-EAR FUNCTION; GUINEA-PIG MODEL; NF-KAPPA-B; PROINFLAMMATORY CYTOKINES; ELECTRODE IMPEDANCE; CONSERVES HEARING; ACOUSTIC HEARING; TGF-BETA AB Objectives: We describe the various molecular and cellular pathways that lead to early and delayed loss of residual hearing after cochlear implantation. Methods: We performed a systematic review using the Medline database with the key words cochlear implant, residual hearing, inflammation, apoptosis, and necrosis. Results: The mechanisms underlying the loss of residual hearing after cochlear implantation are multiple. Early hearing loss may be provoked by the surgical access to the inner ear spaces and by trauma caused by insertion of the electrode array. After the initial trauma, an acute inflammatory response promotes elevated levels of cytokines and reactive oxygen species, which in turn promote sensory cell loss by apoptosis, necrosis, and necrosis-like programmed cell death. Treatments that counteract such an inflammatory reaction, production of reactive oxygen species, and apoptosis are effective at preventing hair cell degeneration. However, delayed hearing loss appears to be a consequence of chronic inflammation with development of fibrotic tissue. The mechanisms that lead to fibrosis are poorly understood, and standard anti-inflammatory drugs are insufficient for preventing its development. Conclusions: Cochlear implantation is followed by an inflammatory response involving several pathways that lead to either short-term or long-term sensory hair cell degeneration. Future studies should focus on revealing the precise molecular mechanisms induced by cochlear implantation to allow the discovery of new targets for the effective prevention and treatment of loss of residual hearing. C1 [Jia, Huan; Wang, Jing; Francois, Florence; Uziel, Alain; Puel, Jean-Luc; Venail, Frederic] Inst Neurosci Montpellier, INSERM, Montpellier, France. [Jia, Huan; Wang, Jing; Francois, Florence; Uziel, Alain; Puel, Jean-Luc; Venail, Frederic] Univ Montpellier I, Montpellier, France. [Uziel, Alain; Venail, Frederic] CHU Gui de Chauliac, Serv ORL, F-34295 Montpellier, France. RP Venail, F (reprint author), CHU Gui de Chauliac, Serv ORL, 80 Ave Augustin Fliche, F-34295 Montpellier, France. FU Advanced Bionics Company FX From INSERM, Institute for Neurosciences of Montpellier (all authors), University Montpellier I (all authors), and the Department of Otorhinolaryngology, CHU Gui de Chauliac (Uziel, Venail), Montpellier, France. This work was supported by a grant to Dr Jia from Advanced Bionics Company. Dr Jia currently works at Shanghai Jiaotong University School of Medicine, Shanghai, China. CR Addams-Williams J, 2011, Cochlear Implants Int, V12 Suppl 2, pS36, DOI 10.1179/146701011X13074645127478 Adunka O, 2006, LARYNGOSCOPE, V116, P1017, DOI 10.1097/01.mlg.0000217224.94804.bb Aggarwal BB, 2000, ANN RHEUM DIS, V59, P6 ARENDS MJ, 1991, INT REV EXP PATHOL, V32, P223 Balkany TJ, 2006, OTOL NEUROTOL, V27, P1083, DOI 10.1097/01.mao.0000244355.34577.85 Bazzoni F, 1996, NEW ENGL J MED, V334, P1717 Braun S, 2011, ORL-J OTO-RHIN-LARYN, V73, P219, DOI 10.1159/000329791 Bursch W, 2001, CELL DEATH DIFFER, V8, P569, DOI 10.1038/sj.cdd.4400852 Chang A, 2009, HEARING RES, V255, P67, DOI 10.1016/j.heares.2009.05.010 Clark G M, 1995, Ann Otol Rhinol Laryngol Suppl, V166, P40 De Ceulaer G, 2003, OTOL NEUROTOL, V24, P769, DOI 10.1097/00129492-200309000-00014 Diegelmann RF, 2004, FRONT BIOSCI, V9, P283, DOI 10.2741/1184 Dinarello Charles A., 1997, Cytokine and Growth Factor Reviews, V8, P253, DOI 10.1016/S1359-6101(97)00023-3 Ding DL, 2007, HEARING RES, V226, P129, DOI 10.1016/j.heares.2006.07.015 Dinh CT, 2009, AUDIOL NEURO-OTOL, V14, P383, DOI 10.1159/000241895 Do K, 2004, INT CONGR SER, V1273, P167, DOI 10.1016/j.ics.2004.08.025 Dorman MF, 2008, AUDIOL NEURO-OTOL, V13, P105, DOI 10.1159/000111782 Eastwood H, 2010, HEARING RES, V259, P24, DOI 10.1016/j.heares.2009.08.010 Elliott SJ, 2011, J ACOUST SOC AM, V130, P1441, DOI 10.1121/1.3607420 Eshraghi Adrien A, 2010, Cochlear Implants Int, V11 Suppl 1, P104, DOI 10.1179/146701010X12671177544104 Eshraghi Adrien A, 2006, Curr Opin Otolaryngol Head Neck Surg, V14, P323, DOI 10.1097/01.moo.0000244189.74431.df Eshraghi AA, 2007, OTOL NEUROTOL, V28, P842, DOI 10.1097/MAO.0b013e31805778fc Fiers W, 1999, ONCOGENE, V18, P7719 Fraysse B, 2006, OTOL NEUROTOL, V27, P624, DOI 10.1097/01.mao.0000226289.04048.0f Fujioka M, 2006, J NEUROSCI RES, V83, P575, DOI 10.1002/jnr.20764 Gantz Bruce J, 2006, Audiol Neurootol, V11 Suppl 1, P63, DOI 10.1159/000095616 Gantz BJ, 2004, ACTA OTO-LARYNGOL, V124, P344, DOI 10.1080/00016480410016423 Gauldie J, 2007, BIOCHEM SOC T, V35, P661 Gstoettner Wolfgang K, 2006, Audiol Neurootol, V11 Suppl 1, P49, DOI 10.1159/000095614 Hirsch T, 1997, ONCOGENE, V15, P1573, DOI 10.1038/sj.onc.1201324 Hold Georgina L, 2009, Fibrogenesis Tissue Repair, V2, P6, DOI 10.1186/1755-1536-2-6 Huang Christie Qi, 2007, Cochlear Implants Int, V8, P123, DOI 10.1002/cii.336 Hughes ML, 2001, EAR HEARING, V22, P471, DOI 10.1097/00003446-200112000-00004 Hwang JH, 2011, J NEUROINFLAMM, V8, DOI 10.1186/1742-2094-8-30 James DP, 2008, AUDIOL NEURO-OTOL, V13, P86, DOI 10.1159/000111780 Jia H, 2011, ANN OTO RHINOL LARYN, V120, P529 Khan M, 2010, NEUROSCI LETT, V479, P249, DOI 10.1016/j.neulet.2010.05.072 Kiefer J, 2004, ACTA OTO-LARYNGOL, V124, P272, DOI 10.1080/00016480310000755 Kitanaka C, 1999, CELL DEATH DIFFER, V6, P508, DOI 10.1038/sj.cdd.4400526 Komeda M, 1999, HEARING RES, V131, P1, DOI 10.1016/S0378-5955(99)00006-4 Leask A, 2008, CELL SIGNAL, V20, P1409, DOI 10.1016/j.cellsig.2008.01.006 Lee J, 2011, AUDIOL NEURO-OTOL, V16, P336, DOI 10.1159/000322307 Leist M, 2001, NAT REV MOL CELL BIO, V2, P589, DOI 10.1038/35085008 Lockshin RA, 2004, ONCOGENE, V23, P2766, DOI 10.1038/sj.onc.1207514 Lockshin RA, 2004, INT J BIOCHEM CELL B, V36, P2405, DOI 10.1016/j.biocel.2004.04.011 Luetje CM, 2007, OTOL NEUROTOL, V28, P473, DOI 10.1097/RMR.0b013e3180423aed Masuda M, 2006, BRAIN RES, V1068, P237, DOI 10.1016/j.brainres.2005.11.020 Menardo J, 2012, ANTIOXID REDOX SIGN, V16, P263, DOI 10.1089/ars.2011.4037 Nam SI, 2006, LARYNGOSCOPE, V116, P2166, DOI 10.1097/01.mlg.0000243202.92548.fa Op de Beeck Ken, 2011, Hear Res, V281, P18, DOI 10.1016/j.heares.2011.07.002 Paasche G, 2009, OTOL NEUROTOL, V30, P592, DOI 10.1097/MAO.0b013e3181ab8fba Pau HW, 2007, LARYNGOSCOPE, V117, P535, DOI 10.1097/MLG.0b013e31802f4169 Pazirandeh S, 2007, JPEN-PARENTER ENTER, V31, P511, DOI 10.1177/0148607107031006511 Proskuryakov SY, 2003, EXP CELL RES, V283, P1, DOI 10.1016/S0014-4827(02)00027-7 Radeloff A, 2007, LARYNGOSCOPE, V117, P58, DOI 10.1097/01.mlg.0000242073.02488.f4 Roland PS, 2007, LARYNGOSCOPE, V117, P1397, DOI 10.1097/MLG.0b013e318064e891 Satoh H, 2002, LARYNGOSCOPE, V112, P1627, DOI 10.1097/00005537-200209000-00019 Satoh H, 2003, LARYNGOSCOPE, V113, P291 Scherer EQ, 2010, STROKE, V41, P2618, DOI 10.1161/STROKEAHA.110.593327 Skarzynski H, 2009, AUDIOL NEURO-OTOL, V14, P39, DOI 10.1159/000206494 So H, 2007, JARO-J ASSOC RES OTO, V8, P338, DOI 10.1007/s10162-007-0084-9 Turner CW, 2008, HEARING RES, V242, P164, DOI 10.1016/j.heares.2007.11.008 Ueha Satoshi, 2012, Front Immunol, V3, P71, DOI 10.3389/fimmu.2012.00071 Van De Water Thomas R, 2010, Cochlear Implants Int, V11 Suppl 1, P42, DOI 10.1179/146701010X12671178390834 Vivero RJ, 2008, LARYNGOSCOPE, V118, P2028, DOI 10.1097/MLG.0b013e31818173ec von Ilberg C, 1999, ORL J OTO-RHINO-LARY, V61, P334, DOI 10.1159/000027695 Wang J, 2008, MINI-REV MED CHEM, V8, P1006, DOI 10.2174/138955708785740599 Wang J, 2007, MOL PHARMACOL, V71, P654, DOI 10.1124/mol.106.028936 Wang J, 2003, J NEUROSCI, V23, P8596 Worsoe L, 2010, OTOL NEUROTOL, V31, P394, DOI 10.1097/MAO.0b013e3181d2796c Yang GSY, 2000, AM J OTOL, V21, P499 Ye Q, 2007, EAR HEARING, V28, P361, DOI 10.1097/01.aud.0000261655.30652.62 Zeng Fan-Gang, 2004, Trends Amplif, V8, P1, DOI 10.1177/108471380400800102 NR 73 TC 4 Z9 4 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD JAN PY 2013 VL 122 IS 1 BP 33 EP 39 PG 7 WC Otorhinolaryngology SC Otorhinolaryngology GA 074YQ UT WOS:000313851400007 PM 23472314 ER PT J AU Awan, SN Solomon, NP Helou, LB Stojadinovic, A AF Awan, Shaheen N. Solomon, Nancy Pearl Helou, Leah B. Stojadinovic, Alexander TI Spectral-Cepstral Estimation of Dysphonia Severity: External Validation SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE cepstrum; dysphonia severity; spectrum; thyroidectomy ID AUDITORY-PERCEPTUAL EVALUATION; BREATHY VOCAL QUALITY; CONTINUOUS SPEECH; VOICE QUALITY; SUSTAINED VOWELS; PEAK PROMINENCE; CAPE-V; INDEX; RELIABILITY; CONSISTENCY AB Objectives: The current study applied an acoustic algorithm incorporating measures from cepstral and spectral analyses, the Cepstral Spectral Index of Dysphonia (CSID), in an attempt to externally validate the CSID as an acoustic estimate of dysphonia severity. Methods: Correlation (Pearson's r) between the CSID and trained listener-perceived severities as rated on the Consensus Auditory-Perceptual Evaluation of Voice (CAPE-V) was calculated from sentence and sustained vowel samples from 56 patients before or after they underwent thyroid surgery. Results: A strong correlation was identified between the mean CSID values calculated across CAPE-V sentences and vowels and the median rating of perceived overall severity (r = 0.82; p < 0.001). The CSID values did not differ significantly from their corresponding auditory-perceptual ratings of dysphonia severity for these samples (CSID: mean, 15.54, SD, 16.63; CAPE-V Severity: mean, 17.33, SD, 13.61; p = 0.16). Conclusions: Independent testing of an acoustic algorithm incorporating measures from cepstral and spectral analyses (the CSID) confirmed a strong correlation of the CSID to perceptual ratings of overall voice quality. This study provides external validation of the CSID as a robust correlate of dysphonia severity as rated by trained listeners. C1 [Awan, Shaheen N.] Bloomsburg Univ Penn, Dept Speech Pathol & Audiol, Bloomsburg, PA 17815 USA. [Helou, Leah B.] Univ Pittsburgh, Dept Commun Sci & Disorders, Pittsburgh, PA USA. [Solomon, Nancy Pearl] Walter Reed Natl Mil Med Ctr, Audiol & Speech Ctr, Bethesda, MD USA. [Stojadinovic, Alexander] Walter Reed Natl Mil Med Ctr, Dept Surg, Div Surg Oncol, Bethesda, MD USA. RP Awan, SN (reprint author), Bloomsburg Univ Penn, Dept Speech Pathol & Audiol, Centennial Hall,400 E 2nd St, Bloomsburg, PA 17815 USA. CR Awan SN, 2010, CLIN LINGUIST PHONET, V24, P742, DOI 10.3109/02699206.2010.492446 Awan SN, 2006, CLIN LINGUIST PHONET, V20, P35, DOI 10.1080/02699200400008353 Awan SN, 2005, J VOICE, V19, P268, DOI 10.1016/j.jvoice.2004.03.005 Awan SN, 2009, CLIN LINGUIST PHONET, V23, P825, DOI 10.3109/02699200903242988 Awan SN, 2011, CLIN LINGUIST PHONET, V25, P302, DOI 10.3109/02699206.2010.535646 Baken R. J, 1987, CLIN MEASUREMENT SPE DEKROM G, 1995, J SPEECH HEAR RES, V38, P794 DEKROM G, 1994, J SPEECH HEAR RES, V37, P985 Halberstam B, 2004, ORL J OTO-RHINO-LARY, V66, P70, DOI 10.1159/000077798 Helou LB, 2010, AM J SPEECH-LANG PAT, V19, P248, DOI 10.1044/1058-0360(2010/09-0012) Heman-Ackah YD, 2003, ANN OTO RHINOL LARYN, V112, P324 Heman-Ackah YD, 2002, J VOICE, V16, P20, DOI 10.1016/S0892-1997(02)00067-X HILLENBRAND J, 1994, J SPEECH HEAR RES, V37, P769 HILLENBRAND J, 1987, J SPEECH HEAR RES, V30, P448 Hillenbrand J, 1996, J SPEECH HEAR RES, V39, P311 Karnell MP, 2007, J VOICE, V21, P576, DOI 10.1016/j.jvoice.2006.05.001 Kempster GB, 2009, AM J SPEECH-LANG PAT, V18, P124, DOI 10.1044/1058-0360(2008/08-0017) KREIMAN J, 1993, J SPEECH HEAR RES, V36, P21 Lowell SY, 2011, J VOICE, V25, pE223, DOI 10.1016/j.jvoice.2010.06.007 BLAND JM, 1986, LANCET, V1, P307 Maryn Y, 2009, J ACOUST SOC AM, V126, P2619, DOI 10.1121/1.3224706 Maryn Y, 2010, J COMMUN DISORD, V43, P161, DOI 10.1016/j.jcomdis.2009.12.004 Maryn Y, 2010, J VOICE, V24, P540, DOI 10.1016/j.jvoice.2008.12.014 NOLL AM, 1967, J ACOUST SOC AM, V41, P293, DOI 10.1121/1.1910339 Orlikoff R, 1999, PHONOSCOPE, V2, P89 Parsa V, 2001, J SPEECH LANG HEAR R, V44, P327, DOI 10.1044/1092-4388(2001/027) Roy N, 2005, LARYNGOSCOPE, V115, P311, DOI 10.1097/01.mlg.0000154739.48314.ee Solomon NP, 2011, J VOICE, V25, pE7, DOI 10.1016/j.jvoice.2009.10.007 Solomon NP, 2012, J VOICE, V26, P711, DOI 10.1016/j.jvoice.2012.06.006 Watts CR, 2011, J SPEECH LANG HEAR R, V54, P1525, DOI 10.1044/1092-4388(2011/10-0209) Wolfe V, 1997, J COMMUN DISORD, V30, P403, DOI 10.1016/S0021-9924(96)00112-8 NR 31 TC 8 Z9 8 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD JAN PY 2013 VL 122 IS 1 BP 40 EP 48 PG 9 WC Otorhinolaryngology SC Otorhinolaryngology GA 074YQ UT WOS:000313851400008 PM 23472315 ER PT J AU Kumai, Y Aoyama, T Nishimoto, K Sanuki, T Minoda, R Yumoto, E AF Kumai, Yoshihiko Aoyama, Takashi Nishimoto, Kohei Sanuki, Tetsuji Minoda, Ryosei Yumoto, Eiji TI Recurrent Laryngeal Nerve Regeneration Through a Silicone Tube Produces Reinnervation Without Vocal Fold Mobility in Rats SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article; Proceedings Paper CT Meeting of the American-Broncho-Esophagological-Association CY APR 18-19, 2012 CL San Diego, CA SP Amer Broncho Esophagol Assoc DE immobile vocal fold; laryngeal reinnervation; neurofilament; silicone tube; synkinesis ID MODEL; RECOVERY; REPAIR; GAP; ELECTROMYOGRAPHY; DENERVATION; SYNKINESIS; MUSCLES; GRAFT AB Objectives: We established an animal model of recurrent-laryngeal nerve reinnervation with persistent vocal fold immobility following recurrent laryngeal nerve injury. Methods: In 36 rats, the left recurrent laryngeal nerve was transected and the stumps were abutted in a silicone tube with a 1-mm interspace, facilitating regeneration. The mobility of the vocal folds was examined endoscopically 5, 10, and 15 weeks later. Electromyography of the thyroarytenoid muscle was performed. Reinnervation was assessed by means of a quantitative immunohistologic evaluation with anti-neurofilament antibody in the nerve both proximal and distal to the silicone tube. The atrophy of the thyroarytenoid muscle was assessed histologically. Results: We observed that all animals had a fixed left vocal fold throughout the study. The average neurofilament expression in the nerve both distal and proximal to the silicone tube, the muscle area, and the amplitude of the compound muscle action potential recorded from the thyroarytenoid muscle on the treated side increased significantly (p < 0.05) over time, demonstrating regeneration through the silicone tube. Conclusions: Recurrent laryngeal nerve regeneration through a silicone tube produced reinnervation without vocal fold mobility in rats. The efficacy of new laryngeal reinnervation treatments can be assessed with this model. C1 [Kumai, Yoshihiko; Aoyama, Takashi; Nishimoto, Kohei; Sanuki, Tetsuji; Minoda, Ryosei; Yumoto, Eiji] Kumamoto Univ, Grad Sch Med, Dept Otolaryngol Head & Neck Surg, Kumamoto 8608556, Japan. RP Kumai, Y (reprint author), Kumamoto Univ, Grad Sch Med, Dept Otolaryngol Head & Neck Surg, 1-1-1 Honjo, Kumamoto 8608556, Japan. CR Aoyama T, 2010, ANN OTO RHINOL LARYN, V119, P823 ASHUR H, 1987, EXP NEUROL, V97, P365, DOI 10.1016/0014-4886(87)90096-3 Blitzer A, 1996, ANN OTO RHINOL LARYN, V105, P764 Crumley RL, 2000, ANN OTO RHINOL LARYN, V109, P365 DELLON AL, 1988, PLAST RECONSTR SURG, V82, P849, DOI 10.1097/00006534-198811000-00020 EVANS PJ, 1991, BRAIN RES, V559, P315, DOI 10.1016/0006-8993(91)90018-Q Gluck T, 1880, ARCH KLIN CHIR, V25, P606 Inagi K, 1998, OTOLARYNG HEAD NECK, V118, P74, DOI 10.1016/S0194-5998(98)70378-X Iroto I, 1968, Ann Otol Rhinol Laryngol, V77, P296 LUNDBORG G, 1982, EXP NEUROL, V76, P361, DOI 10.1016/0014-4886(82)90215-1 MU LC, 1991, LARYNGOSCOPE, V101, P699 NOMOTO M, 1993, ACTA OTO-LARYNGOL, P71 Pitman MJ, 2011, LARYNGOSCOPE, V121, P320, DOI 10.1002/lary.21290 ROMANO VM, 1991, RESTOR NEUROL NEUROS, V3, P75, DOI 10.3233/RNN-1991-3204 SHINDO ML, 1992, LARYNGOSCOPE, V102, P663, DOI 10.1288/00005537-199206000-00012 Tessema B, 2009, LARYNGOSCOPE, V119, P1644, DOI 10.1002/lary.20293 Tessema B, 2008, ANN OTO RHINOL LARYN, V117, P604 Williams L.R., 1983, J COMP NEUROL, V218, P160 Woodson G, 2000, OTOLARYNG CLIN N AM, V33, P895, DOI 10.1016/S0030-6665(05)70250-4 NR 19 TC 2 Z9 2 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD JAN PY 2013 VL 122 IS 1 BP 49 EP 53 PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA 074YQ UT WOS:000313851400009 PM 23472316 ER PT J AU Suh, JD Ramakrishnan, VR Chi, JJ Palmer, JN Chiu, AG AF Suh, Jeffrey D. Ramakrishnan, Vijay R. Chi, John J. Palmer, James N. Chiu, Alexander G. TI Outcomes and Complications of Endoscopic Approaches for Malignancies of the Paranasal Sinuses and Anterior Skull Base SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE complication; craniofacial resection; endoscopic skull base surgery; outcome; sinus tumor; skull base surgery ID CRANIOFACIAL RESECTION; TUMORS; SURGERY; EXPERIENCE; NASAL AB Objectives: Malignant tumors of the paranasal sinuses are traditionally approached by a variety of external incisions. Recent advances in endoscopic endonasal surgery have allowed for some of these tumors to be treated endoscopically. The purpose of this study was to assess the outcomes and complications of the endoscopic approach in a series of patients with paranasal sinus malignancies. Methods: A retrospective chart review was performed of patients with sinonasal or skull base malignancies treated with endoscopic or endoscopic-assisted resections at a tertiary care institution from 2002 to 2010. Patient data were collected on symptoms, tumor type, operative technique, and postoperative course. Baseline risk factors, overall and disease-free survival data, and surgical outcomes were compared between the two groups. Results: Of the total 49 patients, 36 (73%) underwent an endoscopic approach and 13 (27%) underwent endoscopic-assisted approaches. Sarcomas (9 cases) were the most common tumor type, followed by squamous cell carcinoma (8), adenocarcinoma (8), and melanoma (7). The mean follow-up time for all patients was 3.58 years (range, 1.1 to 8.8 years). Surgical complications were more frequent with open approaches than with endoscopic approaches (23.1% versus 5.6%; p = 0.11). Medical complications were significantly more common with open approaches (38.5% versus 8.3%; p = 0.02). The disease-specific mortality rate was 8% (4 of 49). The local tumor recurrence rate was 16% (8 of 49). The 3-year disease-free survival rates were 86.8% in the endoscopic group and 67.7% in the open group (p = 0.047); however, the patients in the endoscopic group had lower T stages (p = 0.0068) and lower ASA scores (p = 0.03). Conclusions: Endoscopic approaches to the sinuses and skull base have become progressively more sophisticated with advances in skull base reconstruction, advances in surgical technique, and improvements in technology. This study demonstrates the relative safety and utility of the endoscopic approach for sinonasal and skull base malignancies. In carefully selected patients, endoscopic approaches demonstrate survival rates comparable to those of traditional surgery, and fewer perioperative complications. With appropriate planning and careful surgical decision-making, endoscopic surgery shows promise as a minimally invasive alternative in the treatment of sinonasal malignancies. C1 [Suh, Jeffrey D.] Univ Calif Los Angeles, Dept Head & Neck Surg, Los Angeles, CA 90095 USA. [Ramakrishnan, Vijay R.] Univ Colorado, Dept Otolaryngol, Aurora, CO USA. [Chi, John J.; Palmer, James N.] Univ Penn Hlth Syst, Dept Otorhinolaryngol Head & Neck Surg, Philadelphia, PA USA. [Palmer, James N.] Univ Penn Hlth Syst, Div Rhinol, Philadelphia, PA USA. [Chiu, Alexander G.] Univ Arizona, Dept Surg, Div Otolaryngol Head & Neck Surg, Tucson, AZ USA. RP Suh, JD (reprint author), Univ Calif Los Angeles, Dept Head & Neck Surg, 200 UCLA Med Plaza,Suite 550, Los Angeles, CA 90095 USA. RI Chiu, Alexander/J-1230-2014 OI Chiu, Alexander/0000-0002-7592-6575 CR Batra PS, 2005, AM J RHINOL, V19, P521 Cohen MA, 2009, ORL J OTO-RHINO-LARY, V71, P123, DOI 10.1159/000209312 Dulguerov P, 2001, CANCER, V92, P3012, DOI 10.1002/1097-0142(20011215)92:12<3012::AID-CNCR10131>3.0.CO;2-E DULGUEROV P, 1992, LARYNGOSCOPE, V102, P843, DOI 10.1288/00005537-199208000-00001 Ganly I, 2005, HEAD NECK-J SCI SPEC, V27, P445, DOI 10.1002/hed.20166 Hanna E, 2009, ARCH OTOLARYNGOL, V135, P1219, DOI 10.1001/archoto.2009.173 Howard DJ, 2006, HEAD NECK-J SCI SPEC, V28, P867, DOI 10.1002/hed.20432 JANECKA IP, 1994, LARYNGOSCOPE, V104, P553 KETCHAM AS, 1966, AM J SURG, V112, P591, DOI 10.1016/0002-9610(66)90327-8 Levine PA, 2009, LARYNGOSCOPE, V119, P3, DOI 10.1002/lary.20047 Lund V, 2007, AM J RHINOL, V21, P89, DOI 10.2500/ajr.2007.21.2957 Nicolai P, 2007, HEAD NECK-J SCI SPEC, V29, P1075, DOI 10.1002/hed.20636 RAVEH J, 1993, ARCH OTOLARYNGOL, V119, P385 Shah JP, 1997, ARCH OTOLARYNGOL, V123, P1312 Silverberg E, 1970, CA Cancer J Clin, V20, P11 SMITH RR, 1954, CANCER, V7, P991, DOI 10.1002/1097-0142(195409)7:5<991::AID-CNCR2820070523>3.0.CO;2-P Snyderman CH, 2008, J SURG ONCOL, V97, P658, DOI 10.1002/jso.21020 Solares CA, 2010, CURR OPIN OTOLARYNGO, V18, P1, DOI 10.1097/MOO.0b013e3283350035 Tessier P, 1967, Ann Chir Plast, V12, P103 Vi Lund, 2010, RHINOL S, V1, P1 Wellman BJ, 1999, SKULL BASE SURG, V9, P41, DOI 10.1055/s-2008-1058171 NR 21 TC 7 Z9 7 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD JAN PY 2013 VL 122 IS 1 BP 54 EP 59 PG 6 WC Otorhinolaryngology SC Otorhinolaryngology GA 074YQ UT WOS:000313851400010 PM 23472317 ER PT J AU Todd, NW Creighton, FX AF Todd, N. Wendell Creighton, Francis X., Jr. TI Malleus and Incus: Correlates of Size SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE incus; malleus; mastoid; temporal bone ID AUDITORY OSSICLES AB Objectives: Wide ranges of dimensions of the malleus and incus have been reported for various human populations. Unaddressed are concordance of malleus and incus sizes, bilateral symmetry, whether ossicle size correlates with otitis media, and whether second-branchial arch derivatives have more variability than first-arch derivatives. We sought to quantitatively describe the malleus and incus in a population not heretofore reported, with the following hypotheses in mind: 1) an ear's malleus and incus sizes are concordant; 2) a cranium's malleus and incus sizes have bilateral symmetry; 3) the sizes of the malleus and incus are unrelated to the mastoid-size indicator of childhood otitis media; and 4) second-branchial arch derivatives have more variability than do first-arch derivatives. Methods: We performed a postmortem material analysis of 41 adult crania without clinical otitis. Results: The sizes of clinically normal mallei (eg, 21.2 to 30.7 mg) and incudes (eg, 24.4 to 37.4 mg) were varied. Concordance of malleus mass and incus mass was found. However, no relation of malleus and incus sizes with mastoid size was found. The variability of first-arch derivatives was similar to that of second-arch derivatives. Conclusions: Clinically normal mallei and incudes had masses and dimensions that varied even more than previously reported. Nevertheless, bilateral symmetry was exhibited, as was concordance of masses. C1 [Todd, N. Wendell; Creighton, Francis X., Jr.] Emory Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, Atlanta, GA 30322 USA. RP Todd, NW (reprint author), Emory Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, 2015 Uppergate Dr NE, Atlanta, GA 30322 USA. CR AWENGEN DF, 1995, ANN OTO RHINOL LARYN, V104, P311 Flohr S, 2010, ANAT REC, V293, P2094, DOI 10.1002/ar.21271 Gundersen T, 1971, PROSTHESES OSSICULAR HARADA O, 1972, PLAST RECONSTR SURG, V50, P48, DOI 10.1097/00006534-197207000-00008 Kirikae I., 1960, STRUCTURE FUNCTION M Park K, 2009, ACTA OTO-LARYNGOL, V129, P419, DOI 10.1080/00016480802587846 Quam R, 2008, J HUM EVOL, V54, P414, DOI 10.1016/j.jhevol.2007.10.005 Todd NW, 2005, LARYNGOSCOPE, V115, P1548, DOI 10.1097/01.mlg.0000173171.32899.4e Todd NW, 2006, LARYNGOSCOPE, V116, P2098 Whyte J, 2009, ANAT HISTOL EMBRYOL, V38, P31, DOI 10.1111/j.1439-0264.2008.00888.x NR 10 TC 2 Z9 2 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD JAN PY 2013 VL 122 IS 1 BP 60 EP 65 PG 6 WC Otorhinolaryngology SC Otorhinolaryngology GA 074YQ UT WOS:000313851400011 PM 23472318 ER PT J AU Ozturk, M Aydin, O AF Ozturk, Murat Aydin, Omer TI Use of Diced Cartilage Grafts Wrapped With Amniotic Membrane in Soft Tissue Augmentation: Experimental Study SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE amniotic membrane; cartilage graft; nasal augmentation; nasal deformity; nasal dorsum; rhinoplasty; tissue augmentation ID SURFACE RECONSTRUCTION; TRANSPLANTATION AB Objectives: Correcting nasal dorsal deformities and irregularities often requires biological or alloplastic materials. In rhinoplasty, a frequent postoperative problem is a rough and rigid nasal dorsum. The purpose of this experimental study was to investigate the feasibility of using diced cartilage grafts wrapped in amniotic membrane for soft tissue augmentation. Methods: Diced cartilage grafts wrapped with amniotic membrane were transplanted to a subcutaneous tunnel that was made in the back in 20 rats. After 2 months, the histopathologic changes that occurred in the grafts were examined by light microscopy. Results: When the diced cartilage grafts wrapped in amniotic membrane were examined, each graft displayed different viability rates. Conclusions: In soft tissue augmentation, especially in the nasal dorsum, amniotic membrane can be used to keep the diced cartilage viable and adjoined. C1 [Ozturk, Murat; Aydin, Omer] Kocaeli Univ, Tip Fak, KBB Anabilim Dali, TR-41380 Umuttepe, Kocaeli, Turkey. RP Ozturk, M (reprint author), Kocaeli Univ, Tip Fak, KBB Anabilim Dali, TR-41380 Umuttepe, Kocaeli, Turkey. CR Brenner KA, 2006, PLAST RECONSTR SURG, V117, P105, DOI 10.1097/01.prs.0000195082.38311.f4 Connon CJ, 2006, AM J OPHTHALMOL, V141, P190, DOI 10.1016/j.ajo.2005.08.027 Coskun BU, 2005, LARYNGOSCOPE, V115, P668, DOI 10.1097/01.mlg.0000161356.35697.f6 Davis JW, 1910, J HOPKINS MED J, V15, P307 Demirkan F, 2002, ARCH ORTHOP TRAUM SU, V122, P396, DOI 10.1007/s00402-002-0418-3 Dua HS, 1999, BRIT J OPHTHALMOL, V83, P748, DOI 10.1136/bjo.83.6.748 Erkol A, 2004, CELL TISSUE BANK, V4, P169 Fernandes M, 2005, CORNEA, V24, P643, DOI 10.1097/01.ico.0000151501.80952.c5 Kazikdas KC, 2007, LARYNGOSCOPE, V117, P1728, DOI 10.1097/MLG.0b013e3180f62b36 KIM JC, 1995, CORNEA, V14, P473 Sangwan Virender S., 2007, Indian Journal of Ophthalmology, V55, P251 NR 11 TC 1 Z9 1 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD JAN PY 2013 VL 122 IS 1 BP 66 EP 70 PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA 074YQ UT WOS:000313851400012 PM 23472319 ER PT J AU Jung, D Bhattacharyya, N AF Jung, David Bhattacharyya, Neil TI Association of Hearing Loss With Decreased Employment and Income Among Adults in the United States SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE employment; hearing loss; income; wage ID EXPENDITURE; PREVALENCE AB Objectives: We evaluated the association of hearing loss with employment and income in adults. Methods: Patients with a coded diagnosis of hearing loss were identified from the 2006 and 2008 Medical Expenditure Panel Survey linked household and medical conditions files and compared to patients without hearing loss. Differences in employment, wage income, and Supplemental Security Income were evaluated with multivariate regression models after adjustment for several demographic and Charlson comorbidity variables. Results: An estimated 933,921 88,474 adults were identified with hearing loss (54.7% of whom were male; mean age for all, 51.0 years). Patients with hearing loss were more likely to be unemployed or partly unemployed than those without hearing loss (adjusted odds ratio, 2.2; p < 0.001). Similarly, adults with hearing loss were less likely to have any wage income than those without hearing loss (adjusted odds ratio, 2.5; p < 0.001). The population with hearing loss earned a mean wage of $23,481 +/- $3,366, versus $31,272 +/- $517 for the population without hearing loss (difference in wages, $7,791; p < 0.001). The association between hearing loss and receiving Supplemental Security Income was not significant (p = 0.109). Conclusions: Adults with hearing loss are more likely to be unemployed and on average earn significantly less wage income than adults without hearing loss. Further work is needed to determine the potential impact of treatment on these differences. C1 [Jung, David] Massachusetts Eye & Ear Infirm, Harvard Otolaryngol Training Program, Boston, MA 02114 USA. [Jung, David; Bhattacharyya, Neil] Harvard Univ, Sch Med, Dept Otol & Laryngol, Cambridge, MA 02138 USA. [Bhattacharyya, Neil] Brigham & Womens Hosp, Div Otolaryngol, Boston, MA 02115 USA. RP Jung, D (reprint author), Massachusetts Eye & Ear Infirm, Harvard Otolaryngol Training Program, 243 Charles St, Boston, MA 02114 USA. CR Balu S, 2006, AM J HYPERTENS, V19, P810, DOI 10.1016/j.amjhyper.2005.12.013 Bhattacharyya N, 2011, LARYNGOSCOPE, V121, P1830, DOI 10.1002/lary.22034 Bhattacharyya N, 2011, ANN OTO RHINOL LARYN, V120, P423 Brown JB, 1999, DIABETES CARE, V22, P1116, DOI 10.2337/diacare.22.7.1116 Cohen JW, 2009, MED CARE, V47, pS44, DOI 10.1097/MLR.0b013e3181a23e3a Cruickshanks KJ, 2010, HEARING RES, V264, P3 DHoore W, 1996, J CLIN EPIDEMIOL, V49, P1429, DOI 10.1016/S0895-4356(96)00271-5 Hasson D, 2010, J EPIDEMIOL COMMUN H, V64, P453, DOI 10.1136/jech.2009.095430 Hasson D, 2011, BMC PUBLIC HEALTH, V11, DOI 10.1186/1471-2458-11-130 Helvik AS, 2009, AM J PUBLIC HEALTH, V99, P1376, DOI 10.2105/AJPH.2007.133215 Kamble S, 2009, J ASTHMA, V46, P73, DOI 10.1080/02770900802503107 Kramer SE, 2006, INT J AUDIOL, V45, P503, DOI 10.1080/14992020600754583 Shargorodsky J, 2010, JAMA-J AM MED ASSOC, V304, P772, DOI 10.1001/jama.2010.1124 Sullivan PW, 2010, J RHEUMATOL, V37, P544, DOI 10.3899/jrheum.081306 NR 14 TC 5 Z9 5 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD DEC PY 2012 VL 121 IS 12 BP 771 EP 775 PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA 056CX UT WOS:000312467100001 PM 23342548 ER PT J AU Sarny, S Habermann, W Ossimitz, G Stammberger, H AF Sarny, Stephanie Habermann, Walter Ossimitz, Guenther Stammberger, Heinz TI Significant Post-tonsillectomy Pain Is Associated With Increased Risk of Hemorrhage SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE hemorrhage; pain; pain type; tonsillectomy ID COMPARING POSTOPERATIVE PAIN; CONTROLLED-TRIAL; ADENOTONSILLECTOMY; ANTIBIOTICS; COBLATION; EFFICACY AB Objectives: In this study, we set out to assess the association of postoperative pain types with the risk of hemorrhage after tonsillectomy. Methods: The questionnaire-based study was conducted on 335 patients who had undergone tonsillectomy. Hemorrhage risk and postoperative pain were evaluated retrospectively with use of a visual analog scale for 5 time periods (day 1, days 2 to 3, days 4 to 7, days 7 to 14, and later). Results: Five pain types were identified by a cluster analysis. The most frequent pain types, I (24.8%; 83 patients) and 11 (50.8%; 170 patients), show decreasing pain, with pain type II starting on a higher level than pain type I. Pain types III (10.7%; 36 patients) and IV (1.2%; 4 patients) start at a low level with increasing pain for the first few days. In type III, pain decreases after 1 week, whereas type IV consists of a high level of pain for more than 2 weeks. Pain type V (12.5%; 42 patients) involves a very high level of pain from the beginning, which decreases only gradually. Pain type I is associated with a low hemorrhage rate. Patients with increasing pain (types III and IV) and pain type V show a significantly higher hemorrhage risk. Conclusions: Patients who have severe or increasing pain in the first few days after tonsillectomy have a significantly higher risk of hemorrhage. C1 [Sarny, Stephanie; Habermann, Walter; Stammberger, Heinz] Med Univ Graz, Dept Gen Otorhinolaryngol Head & Neck Surg, Graz, Austria. [Ossimitz, Guenther] Univ Klagenfurt, Dept Math, Klagenfurt, Austria. RP Sarny, S (reprint author), Auenbruggerpl 26-28, A-8036 Graz, Austria. EM stephanie@sarny.at CR Burkart CM, 2005, LARYNGOSCOPE, V115, P997, DOI 10.1097/01.MLG.0000163749.77019.8F Cohen MS, 2007, LARYNGOSCOPE, V117, P1855, DOI 10.1097/MLG.0b013e318123ee40 Cushing SL, 2009, OTOLARYNG HEAD NECK, V141, P710, DOI 10.1016/j.otohns.2009.08.023 Ericsson E, 2007, LARYNGOSCOPE, V117, P654, DOI 10.1097/mlg.0b013e318030ca69 Hasan H, 2008, EUR ARCH OTO-RHINO-L, V265, P817, DOI 10.1007/s00405-007-0537-0 Hultcrantz E, 1999, INT J PEDIATR OTORHI, V51, P171, DOI 10.1016/S0165-5876(99)00274-8 Johnson LB, 2002, LARYNGOSCOPE, V112, P35 Johnson PE, 2009, ARCH OTOLARYNGOL, V135, P984, DOI 10.1001/archoto.2009.146 Lachanas VA, 2005, LARYNGOSCOPE, V115, P1591, DOI 10.1097/01.mlg.0000172044.57285.b6 Lavy JA, 1997, INT J PEDIATR OTORHI, V42, P11, DOI 10.1016/S0165-5876(97)00107-9 Bhattacharyya N, 2010, LARYNGOSCOPE, V120, P821, DOI 10.1002/lary.20852 Parker D, 2009, CLIN OTOLARYNGOL, V34, P225, DOI 10.1111/j.1749-4486.2009.01932.x Rosbe KW, 2000, ARCH OTOLARYNGOL, V126, P718 Warnock FF, 1998, PAIN, V75, P37, DOI 10.1016/S0304-3959(97)00202-9 Wilson YL, 2009, LARYNGOSCOPE, V119, P162, DOI 10.1002/lary.20024 Windfuhr JP, 2008, LARYNGOSCOPE, V118, P1389, DOI 10.1097/MLG.0b013e3181734f7e NR 16 TC 7 Z9 7 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD DEC PY 2012 VL 121 IS 12 BP 776 EP 781 PG 6 WC Otorhinolaryngology SC Otorhinolaryngology GA 056CX UT WOS:000312467100002 PM 23342549 ER PT J AU Gfeller, K Turner, C Oleson, J Kliethermes, S Driscoll, V AF Gfeller, Kate Turner, Christopher Oleson, Jacob Kliethermes, Stephanie Driscoll, Virginia TI Accuracy of Cochlear Implant Recipients in Speech Reception in the Presence of Background Music SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE cochlear implant; music; pitch; preserved hearing; speech perception ID ELECTRIC HEARING; MELODY RECOGNITION; PITCH PERCEPTION; ACOUSTIC HEARING; LISTENERS; NOISE; BENEFITS; PRESERVATION; RESOLUTION; MASKERS AB Objectives: This study examined speech recognition abilities of cochlear implant (CI) recipients in the spectrally complex listening condition of 3 contrasting types of background music, and compared performance based upon listener groups: Cl recipients using conventional long-electrode devices, Hybrid Cl recipients (acoustic plus electric stimulation), and normal-hearing adults. Methods: We tested 154 long-electrode CI recipients using varied devices and strategies, 21 Hybrid Cl recipients, and 49 normal-hearing adults on closed-set recognition of spondees presented in 3 contrasting forms of background music (piano solo, large symphony orchestra, vocal solo with small combo accompaniment) in an adaptive test. Outcomes: Signal-to-noise ratio thresholds for speech in music were examined in relation to measures of speech recognition in background noise and multitalker babble, pitch perception, and music experience. Results: The signal-to-noise ratio thresholds for speech in music varied as a function of category of background music, group membership (long-electrode, Hybrid, normal-hearing), and age. The thresholds for speech in background music were significantly correlated with measures of pitch perception and thresholds for speech in background noise; auditory status was an important predictor. Conclusions: Evidence suggests that speech reception thresholds in background music change as a function of listener age (with more advanced age being detrimental), structural characteristics of different types of music, and hearing status (residual hearing). These findings have implications for everyday listening conditions such as communicating in social or commercial situations in which there is background music. C1 [Gfeller, Kate] Univ Iowa, Dept Otolaryngol, Univ Iowa Hosp & Clin, Iowa Cochlear Implant Clin Res Ctr, Iowa City, IA 52242 USA. [Gfeller, Kate; Turner, Christopher] Univ Iowa, Univ Iowa Hosp & Clin, Dept Commun Sci & Disorders, Iowa City, IA 52242 USA. [Gfeller, Kate] Univ Iowa, Univ Iowa Hosp & Clin, Sch Mus, Iowa City, IA 52242 USA. [Turner, Christopher] Univ Iowa, Univ Iowa Hosp & Clin, Dept Otolaryngol Head & Neck Surg, Iowa City, IA 52242 USA. [Oleson, Jacob; Kliethermes, Stephanie] Univ Iowa, Univ Iowa Hosp & Clin, Dept Biostat, Iowa City, IA 52242 USA. RP Gfeller, K (reprint author), Univ Iowa, Dept Otolaryngol, Univ Iowa Hosp & Clin, Iowa Cochlear Implant Clin Res Ctr, 200 Hawkins Dr,21035 Pomerantz Family Pavil, Iowa City, IA 52242 USA. FU National Institute on Deafness and Communication Disorders, National Institutes of Health [2 P50 DC00242, 1R01 DC000377]; General Clinical Research Centers Program, National Center for Research Resources, National Institutes of Health [RR00059]; Iowa Lions Foundation FX This study was supported by grant 2 P50 DC00242 and grant 1R01 DC000377 from the National Institute on Deafness and Communication Disorders, National Institutes of Health, by grant RR00059 from the General Clinical Research Centers Program, National Center for Research Resources, National Institutes of Health, and by the Iowa Lions Foundation. CR ASSMANN PF, 1990, J ACOUST SOC AM, V88, P680, DOI 10.1121/1.399772 BROKX JPL, 1982, J PHONETICS, V10, P23 Chasin M, 2003, HEARING J, V56, P41 Chasin M., 2003, HEARING J, V56, P36 Chasin M, 2003, HEAR J, V56, P40 Dillier N, 2004, P 3 INT PED C NOV CH, P163 Dorman MF, 2008, AUDIOL NEURO-OTOL, V13, P105, DOI 10.1159/000111782 Ekstrom SR, 2011, NOISE HEALTH, V13, P277, DOI 10.4103/1463-1741.82960 El Fata F, 2009, AUDIOL NEURO-OTOL, V14, P14, DOI 10.1159/000206491 Friesen LM, 2001, J ACOUST SOC AM, V110, P1150, DOI 10.1121/1.1381538 Fu QJ, 1998, J ACOUST SOC AM, V104, P3586, DOI 10.1121/1.423941 Gantz BJ, 2005, LARYNGOSCOPE, V115, P796, DOI 10.1097/01.MLG.0000157695.07536.D2 Gantz BJ, 2003, LARYNGOSCOPE, V113, P1726, DOI 10.1097/00005537-200310000-00012 Gantz BJ, 2009, AUDIOL NEURO-OTOL, V14, P32, DOI 10.1159/000206493 Gfeller Kate, 2002, Cochlear Implants Int, V3, P29, DOI 10.1002/cii.50 Gfeller K, 2000, J Am Acad Audiol, V11, P390 Gfeller K, 2007, EAR HEARING, V28, P412, DOI 10.1097/AUD.0b013e3180479318 Gfeller K, 2010, J AM ACAD AUDIOL, V21, P28, DOI 10.3766/jaaa.21.1.4 Gfeller K., 2008, INTRO MUSIC THERAPY, P41 GORDONSALANT S, 1995, J SPEECH HEAR RES, V38, P1150 Harris R. W., 1991, SPEECH AUDIOMETRY MA Henry BA, 2005, J ACOUST SOC AM, V118, P1111, DOI 10.1121/1.1944567 Kong YY, 2005, J ACOUST SOC AM, V117, P1351, DOI 10.1121/1.1857526 Martin JS, 2005, J REHABIL RES DEV, V42, P25, DOI 10.1682/JRRD.2004.12.0164 McDermott Hugh, 2011, Seminars in Hearing, V32, P103, DOI 10.1055/s-0031-1271951 Nelson PB, 2004, J ACOUST SOC AM, V115, P2286, DOI 10.1121/1.1703538 Qin MK, 2003, J ACOUST SOC AM, V114, P446, DOI 10.1121/1.1579009 Qin MK, 2006, J ACOUST SOC AM, V119, P2417, DOI 10.1121/1.2178719 Stickney GS, 2004, J ACOUST SOC AM, V116, P1081, DOI 10.1121/1.1772399 Turner CW, 2004, J ACOUST SOC AM, V115, P1729, DOI 10.1121/1.1687425 Turner Christopher W, 2006, Audiol Neurootol, V11 Suppl 1, P2, DOI 10.1159/000095606 Wilson BS, 2000, COCHLEAR IMPLANTS, P109 Woodson EA, 2010, OTOL NEUROTOL, V31, P1144, DOI 10.1097/MAO.0b013e3181edb8b2 NR 33 TC 2 Z9 2 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD DEC PY 2012 VL 121 IS 12 BP 782 EP 791 PG 10 WC Otorhinolaryngology SC Otorhinolaryngology GA 056CX UT WOS:000312467100003 PM 23342550 ER PT J AU Lee, DH Kim, CS Park, CW Chung, DY AF Lee, Dong-Hee Kim, Choung-Soo Park, Chang-Woo Chung, Dae-Young TI Is Preoperative Computed Tomographic Density Measurement of Soft Tissues Helpful in the Diagnosis of Cholesteatoma? SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE cholesteatoma; computed tomography; Hounsfield unit ID SUPPURATIVE OTITIS-MEDIA; RECURRENT CHOLESTEATOMA; MASTOID SURGERY; CT; OBLITERATION; MANAGEMENT AB Objectives: We undertook to verify the usefulness of computed tomography Hounsfield units (HU) in differentiating cholesteatoma from inflammatory tissue. Methods: In 91 enrolled cases, the lesions were classified according to the gross pathology, and the specific locations of each lesion were documented by 1 surgeon within 1 day after the operation. The densities in HU of cholesteatoma and non-cholesteatoma lesions were retrospectively measured 3 times by the same examiner, and the difference between the two groups was analyzed. The interobserver reliability among the 3 examiners was assessed to verify the confidence level of the HU measurements in preoperative detection of cholesteatoma. Results: The mean HU values of cholesteatoma were 35.7 to 66.6 HU, and those of non-cholesteatoma lesions were 32.9 to 51.3 HU. A general linear model repeated-measures analysis of variance did not show any significant difference between the cholesteatoma and non-cholesteatoma lesions (p = 0.305). The general linear model-repeated-measures analysis of variance showed a significant difference of the measured HU levels among the 3 examiners (p = 0.021). Conclusions: This study showed that the HU values on preoperative computed tomography did not suffice for the detection of cholesteatoma lesions. A clinician's physical examination together with an interpretation of computed tomography is still the "gold standard" method. C1 [Lee, Dong-Hee; Kim, Choung-Soo; Park, Chang-Woo; Chung, Dae-Young] Catholic Univ Korea, Coll Med, Dept Otolaryngol Head & Neck Surg, Seoul, South Korea. RP Lee, DH (reprint author), Catholic Univ Korea, Dept Otolaryngol Head & Neck Surg, Uijeongbu St Marys Hosp, 271 Cheonbo St, Uijeongbu City 480717, Gyeonggi Do, South Korea. CR Barath K, 2011, AM J NEURORADIOL, V32, P221, DOI 10.3174/ajnr.A2052 Bodenez C, 2008, EUR ARCH OTO-RHINO-L, V265, P1301, DOI 10.1007/s00405-008-0633-9 Chowdhury R, 2010, RADIOLOGY GLANCE, P17 Gray RF, 1999, J LARYNGOL OTOL, V113, P881 Groell R, 2000, COMPUT MED IMAG GRAP, V24, P53, DOI 10.1016/S0895-6111(99)00043-9 LEIGHTON SEJ, 1993, CLIN OTOLARYNGOL, V18, P23, DOI 10.1111/j.1365-2273.1993.tb00804.x Mustafa A, 2008, EUR ARCH OTO-RHINO-L, V265, P1477, DOI 10.1007/s00405-008-0707-8 Park MH, 2011, AM J OTOLARYNG, V32, P194, DOI 10.1016/j.amjoto.2010.01.008 PHELPS PD, 1990, CLIN RADIOL, V41, P156, DOI 10.1016/S0009-9260(05)80958-4 Rasouli ML, 2006, CORONARY ARTERY DIS, V17, P359, DOI 10.1097/00019501-200606000-00006 Saw KC, 2000, AM J ROENTGENOL, V175, P329 Tierney PA, 1999, CLIN OTOLARYNGOL, V24, P274, DOI 10.1046/j.1365-2273.1999.00238.x Tipper D, 2011, CT ANATOMY RADIOTHER, P8 Travetti O, 2010, VET RADIOL ULTRASOUN, V51, P374, DOI 10.1111/j.1740-8261.2010.01682.x WAKE M, 1992, J LARYNGOL OTOL, V106, P393, DOI 10.1017/S0022215100119644 Walshe P, 2002, CLIN OTOLARYNGOL, V27, P95, DOI 10.1046/j.1365-2273.2002.00538.x Yung MMW, 1997, CLIN OTOLARYNGOL, V22, P553, DOI 10.1046/j.1365-2273.1997.00077.x NR 17 TC 1 Z9 1 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD DEC PY 2012 VL 121 IS 12 BP 792 EP 797 PG 6 WC Otorhinolaryngology SC Otorhinolaryngology GA 056CX UT WOS:000312467100004 PM 23342551 ER PT J AU Sato, K Umeno, H Nakashima, T AF Sato, Kiminori Umeno, Hirohito Nakashima, Tadashi TI Vocal Fold Stem Cells and Their Niche in the Human Vocal Fold SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article; Proceedings Paper CT Meeting of the American-Broncho-Esophagological-Association CY APR 18-19, 2012 CL San Diego, CA SP Amer Broncho Esophagol Assoc DE human vocal fold; macula flava; mesenchymal stem cell; stem cell niche; vocal fold stellate cell; vocal fold stem cell ID STORING STELLATE CELLS; SIDE POPULATION CELLS; MACULA FLAVA; FUNCTIONAL HISTOLOGY; SYSTEM AB Objectives: Vocal fold stellate cells (VFSCs) in the maculae flavae have many morphological differences from conventional fibroblasts in the human vocal fold mucosa. It is uncertain whether the VFSCs are derived from the same embryonic source as conventional fibroblasts. The purpose of this study was to investigate the sternness of the VFSCs and whether the pericellular matrices in the maculae flavae are a hyaluronan-rich matrix, which is required for a stem cell niche. Methods: Paraffin-embedded specimens were stained with Alcian blue (pH 2.5) for a hyaluronidase digestion study. Immunoreactivity to antibodies directed to CD44, CD 133, Oct-4, Ki67, and telomerase was investigated in 5 human adult vocal fold mucosae. Results: The VFSCs were resting cells (Go-phase) and expressed a mesenchymal stem cell marker. The VFSCs did not express hematopoietic or embryonic stem cell markers. Telomerase resided in the VFSCs. The hyaluronan concentration in the maculae flavae was high and the VFSCs expressed hyaluronan receptors, indicating that maculae flavae are characterized by a certain criterion of hyaluronan-rich matrix. Conclusions: There is growing evidence that the VFSCs in the human maculae flavae are somatic (mesenchymal) stem cells of the vocal fold, and that the maculae flavae may be a candidate for a stem cell niche that is a microenvironment nurturing a pool of VFSCs. C1 [Sato, Kiminori; Umeno, Hirohito; Nakashima, Tadashi] Kurume Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, Kurume, Fukuoka 8300011, Japan. RP Sato, K (reprint author), Kurume Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, 67 Asahi Machi, Kurume, Fukuoka 8300011, Japan. CR Becker WM, 2006, WORLD CELL, P554 Eng FJ, 2000, AM J PHYSIOL-GASTR L, V279, pG7 Gugatschka M, 2011, LARYNGOSCOPE, V121, P1662, DOI 10.1002/lary.21817 Hanson SE, 2010, LARYNGOSCOPE, V120, P546, DOI 10.1002/lary.20797 Haylock DN, 2006, REGEN MED, V1, P437, DOI 10.2217/17460751.1.4.437 Li LH, 2005, ANNU REV CELL DEV BI, V21, P605, DOI 10.1146/annurev.cellbio.21.012704.131525 Preston Marnie, 2011, Front Biosci (Schol Ed), V3, P1165 Sato K, 2003, ACTA OTO-LARYNGOL, V123, P106, DOI 10.1080/0036554021000028077 Sato K, 2012, ANN OTO RHINOL LARYN, V121, P51 Sato K, 2004, ANN OTO RHINOL LARYN, V113, P108 SATO K, 1990, ANN OTO RHINOL LARYN, V99, P363 Sato K, 2010, FOLIA PHONIATR LOGO, V62, P178, DOI 10.1159/000314261 Sato K, 2008, AM J OTOLARYNG, V29, P312, DOI 10.1016/j.amjoto.2007.09.007 Sato K, 2001, ANN OTO RHINOL LARYN, V110, P319 Sato K, 2005, ANN OTO RHINOL LARYN, V114, P517 Sato K, 2010, FOLIA PHONIATR LOGO, V62, P263, DOI 10.1159/000316962 Sawitza I, 2009, HEPATOLOGY, V50, P1617, DOI 10.1002/hep.23184 Tool B. P., 1991, CELL BIOL EXTRACELLU, P305 Yamashita M, 2007, ANN OTO RHINOL LARYN, V116, P847 Zhao LN, 2007, J MOL HISTOL, V38, P53, DOI 10.1007/s10735-007-9078-5 NR 20 TC 5 Z9 5 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD DEC PY 2012 VL 121 IS 12 BP 798 EP 803 PG 6 WC Otorhinolaryngology SC Otorhinolaryngology GA 056CX UT WOS:000312467100005 PM 23342552 ER PT J AU Mizuta, M Hirano, S Ohno, S Tateya, I Kanemaru, S Nakamura, T Ito, J AF Mizuta, Masanobu Hirano, Shigeru Ohno, Satoshi Tateya, Ichiro Kanemaru, Shin-ichi Nakamura, Tatsuo Ito, Juichi TI Expression of Reactive Oxygen Species During Wound Healing of Vocal Folds in a Rat Model SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article; Proceedings Paper CT Meeting of the American-Broncho-Esophagological-Association CY APR 18-19, 2012 CL San Diego, CA SP Amer Broncho Esophagol Assoc DE 4-hydroxy-2-nonenal; reactive oxygen species; vocal fold; wound healing ID OXIDATIVE STRESS; REDOX CONTROL; REPAIR; EXERCISE; DISEASES; ULCERS; RAC2 AB Objectives: Previous studies have indicated that although normal wound healing requires low levels of reactive oxygen species (ROS), excessive amounts of ROS impair wound healing. In injured vocal folds, this excess may result in dysphonia due to scarring that is difficult to treat. However, the expression of ROS during vocal fold wound healing has yet to be investigated. In this study, we assessed the expression and localization of ROS in injured vocal folds by immunohistochemical analysis. Methods: Vocal folds of Sprague-Dawley rats were unilaterally injured by stripping the mucosa under transoral endoscopy. The larynges were harvested at specific time points after injury and were immunohistochemically examined for 4-hydroxy-2-nonenal (4-HNE), an ROS marker, and for the presence of inflammatory cells. Results: We found that 4-HNE-immunopositive cells were significantly increased in the lamina propria of the injured vocal folds as compared to the normal vocal folds on postinjury days 1 and 3. More than half of the 4-HNE-immunopositive cells were also immunopositive for a macrophage- and granulocyte-specific antibody. Conclusions: This study suggests that a large amount of ROS is produced during early-phase wound healing, until postinjury day 3, and that this period may be crucial for regulating ROS levels. The results also suggest that inflammatory cells may contribute to ROS generation. C1 [Hirano, Shigeru] Kyoto Univ, Grad Sch Med, Dept Otolaryngol Head & Neck Surg, Sakyo Ku, Kyoto 6068507, Japan. [Nakamura, Tatsuo] Kyoto Univ, Inst Frontier Med Sci, Dept Bioartificial Organs, Kyoto 6068507, Japan. [Kanemaru, Shin-ichi] Fdn Biomed Res & Innovat, Dept Regenerat Treatment Tympan Membrane, Dept Otolaryngol, Kobe, Hyogo, Japan. [Kanemaru, Shin-ichi] Kitano Hosp, Tazuke Kofukai Med Res Inst, Dept Otolaryngol Head & Neck Surg, Osaka, Japan. RP Hirano, S (reprint author), Kyoto Univ, Grad Sch Med, Dept Otolaryngol Head & Neck Surg, Sakyo Ku, Kyoto 6068507, Japan. CR Afanas'ev I, 2010, CURR DRUG METAB, V11, P409 Alper R, 2011, LARYNGOSCOPE, V121, P2180, DOI 10.1002/lary.22157 Alvarez A, 2006, FASEB J, V20, P2396, DOI 10.1096/fj.05-5696fje Ambruso DR, 2000, P NATL ACAD SCI USA, V97, P4654, DOI 10.1073/pnas.080074897 auf dem Keller U, 2006, J INVEST DERMATOL, V11, P106 Branski RC, 2009, LARYNGOSCOPE, V119, P2014, DOI 10.1002/lary.20592 DAVIES KJA, 1982, BIOCHEM BIOPH RES CO, V107, P1198, DOI 10.1016/S0006-291X(82)80124-1 Fitzmaurice SD, 2011, SKIN PHARMACOL PHYS, V24, P113, DOI 10.1159/000322643 Floyd RA, 2011, FREE RADICAL BIO MED, V51, P931, DOI 10.1016/j.freeradbiomed.2011.04.014 Gupta A, 2002, MOL CELL BIOCHEM, V241, P1, DOI 10.1023/A:1020804916733 Hirano Shigeru, 2005, Curr Opin Otolaryngol Head Neck Surg, V13, P143, DOI 10.1097/01.moo.0000162261.49739.b7 James TJ, 2003, WOUND REPAIR REGEN, V11, P172, DOI 10.1046/j.1524-475X.2003.11304.x Kumin A, 2006, AM J PATHOL, V169, P1194, DOI 10.2353/ajpath.2006.060119 Moseley R, 2004, WOUND REPAIR REGEN, V12, P419, DOI 10.1111/j.1067-1927.2004.12406.x Ojha N, 2008, FREE RADICAL BIO MED, V44, P682, DOI 10.1016/j.freeradbiomed.2007.10.056 Park E, 2011, BIOCHEM BIOPH RES CO, V410, P514, DOI 10.1016/j.bbrc.2011.06.013 ROBINSON AP, 1986, IMMUNOLOGY, V57, P239 Roy S, 2006, MOL THER, V13, P211, DOI 10.1016/j.ymthe.2005.07.684 Schafer M, 2008, PHARMACOL RES, V58, P165, DOI 10.1016/j.phrs.2008.06.004 Schafer M, 2007, ANNU REV CELL DEV BI, V23, P69, DOI 10.1146/annurev.cellbio.23.090506.123609 Sen CK, 2003, WOUND REPAIR REGEN, V11, P431, DOI 10.1046/j.1524-475X.2003.11607.x Sen CK, 2008, BBA-GEN SUBJECTS, V1780, P1348, DOI 10.1016/j.bbagen.2008.01.006 Tateya T, 2005, ANN OTO RHINOL LARYN, V114, P183 Urso ML, 2003, TOXICOLOGY, V189, P41, DOI 10.1016/S0300-483X(03)00151-3 Werner S, 2003, PHYSIOL REV, V83, P835, DOI 10.1152/physrev.00031.2002 Wlaschek M, 2005, WOUND REPAIR REGEN, V13, P452, DOI 10.1111/j.1067-1927.2005.00065.x Yeoh-Ellerton S, 2003, J INVEST DERMATOL, V121, P918, DOI 10.1046/j.1523-1747.2003.12471.x NR 27 TC 2 Z9 2 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD DEC PY 2012 VL 121 IS 12 BP 804 EP 810 PG 7 WC Otorhinolaryngology SC Otorhinolaryngology GA 056CX UT WOS:000312467100006 PM 23342553 ER PT J AU Ciabatti, PG Burali, G D'Ascanio, L AF Ciabatti, Pier Guido Burali, Giulia D'Ascanio, Luca TI Single-Incision Robot-Assisted Transaxillary Surgery for Early-Stage Papillary Thyroid Cancer SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE da Vinci surgical system; learning curve; robotic thyroidectomy; thyroid cancer ID ENDOSCOPIC THYROIDECTOMY; NECK-SURGERY; AXILLARY APPROACH; PARATHYROIDECTOMY AB Objectives: We describe the surgical details, results, and learning curve of a proposed technique for single-incision transaxillary robot-assisted thyroid surgery for early-stage thyroid cancer. Methods: We performed single-incision transaxillary robot-assisted total thyroidectomy with the da Vinci surgical system in 29 patients (5 male, 24 female; median age, 45 years; age range, 19 to 69 years) with papillary thyroid cancer (cT1 NO) using our proposed technique with selected instrumentation. Preoperative ultrasound examination, fine-needle aspiration cytology, and contrast computed tomographic scanning were performed in all subjects. Ultrasound examination was carried out I month after surgery to assess the amount of residual thyroid tissue. Results: No procedure was converted to conventional open surgery. The mean total operation time was 178.51 +/- 24.18 minutes, and the mean console time was 126.10 +/- 14.47 minutes. A progressive reduction of console time was noted (160 minutes for the first procedure versus 102 minutes for the last one). No cases of permanent hypocalcemia, recurrent laryngeal nerve palsy, or postoperative bleeding occurred. The mean amount of postoperative residual thyroid tissue on ultrasound examination was 8.93 +/- 2.15 mm. Conclusions: The single-incision transaxillary robot-assisted total thyroidectomy we propose is a feasible and relatively safe procedure in selected patients with early-stage thyroid cancer. C1 [Ciabatti, Pier Guido; Burali, Giulia; D'Ascanio, Luca] San Donato Civil Hosp, Dept Otolaryngol Head & Neck Surg, Arezzo, Italy. RP D'Ascanio, L (reprint author), Citta di Castello Civil Hosp, Dept Otolaryngol Head & Neck Surg, Via Engels, I-06012 Citta Di Castello, Italy. CR Gagner M, 2001, THYROID, V11, P161, DOI 10.1089/105072501300042848 Gagner M, 1996, BRIT J SURG, V83, P875, DOI 10.1002/bjs.1800830656 Ikeda Y, 2000, J AM COLL SURGEONS, V191, P336, DOI 10.1016/S1072-7515(00)00342-2 Kang Sang-Wook, 2009, J Am Coll Surg, V209, pe1, DOI 10.1016/j.jamcollsurg.2009.05.003 Kang SW, 2009, SURGERY, V146, P1048, DOI 10.1016/j.surg.2009.09.007 Kang SW, 2009, SURG ENDOSC, V23, P2399, DOI 10.1007/s00464-009-0366-x Kang SW, 2009, ENDOCR J, V56, P361 Lee Kyu Eun, 2009, Surg Laparosc Endosc Percutan Tech, V19, pe71, DOI 10.1097/SLE.0b013e3181a4ccae Lobe TE, 2005, J LAPAROENDOSC ADV S, V15, P647, DOI 10.1089/lap.2005.15.647 Miccoli P, 2000, LANGENBECK ARCH SURG, V385, P261, DOI 10.1007/s004230000141 Miyano G, 2008, J PEDIATR SURG, V43, P299, DOI 10.1016/j.jpedsurg.2007.10.018 O'Connell DA, 2008, ARCH OTOLARYNGOL, V134, P85, DOI 10.1001/archotol.134.1.85 Ohgami M, 2000, SURG LAPARO ENDO PER, V10, P1, DOI 10.1097/00019509-200002000-00001 Ryu Haeng Rang, 2010, J Am Coll Surg, V211, pe13, DOI 10.1016/j.jamcollsurg.2010.05.021 Shimizu K, 1999, J AM COLL SURGEONS, V188, P697, DOI 10.1016/S1072-7515(99)00048-4 Zidan J, 2004, INT J RADIAT ONCOL, V59, P1330, DOI 10.1016/j.ijrobp.2004.01.036 NR 16 TC 2 Z9 2 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD DEC PY 2012 VL 121 IS 12 BP 811 EP 815 PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA 056CX UT WOS:000312467100007 PM 23342554 ER PT J AU Takagi, D Nakamaru, Y Suzuki, M Fukuda, S AF Takagi, Dai Nakamaru, Yuji Suzuki, Masanobu Fukuda, Satoshi TI Dysregulation of Histone Deacetylase and Histone Acetyltransferase in Development of Wegener's Granulomatosis SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE ANCA; anti-neutrophil cytoplasmic antibody; histone acetyltransferases; histone deacetylase; Wegener's granulomatosis ID OBSTRUCTIVE PULMONARY-DISEASE; OXIDATIVE STRESS; ACETYLATION; NEUTROPHILS; EXPRESSION; COPD AB Objectives: We investigated the function of the decreases in histone deacetylase (HDAC) and histone acetyltransferase (HAT) in Wegener's granulomatosis (WG) patients compared with healthy subjects. Methods: Seven patients with WG, diagnosed according to the American College of Rheumatology criteria, were examined. Fresh peripheral blood mononuclear cells were isolated from the WG patients and healthy subjects, and then whole-cell proteins were prepared. We measured the total HDAC and HAT activity in peripheral blood mononuclear cells from WG patients. The HDAC2 expression was analyzed by Western blot. Results: We found that total HDAC activity was significantly decreased in WG patients compared to that in healthy subjects (p < 0.05). Furthermore, we found a negative correlation between total HDAC activity and C-reactive protein titer. Total HAT activity was significantly increased in WG patients. Conclusions: These results demonstrated reduced HDAC activity and an increase in HAT activity in WG. These were associated with concomitant induction of WG-related inflammation. Thus, dysregulation of HDAC and HAT may contribute to the disease pathogenesis of WG. C1 [Takagi, Dai; Nakamaru, Yuji; Suzuki, Masanobu; Fukuda, Satoshi] Hokkaido Univ, Grad Sch Med, Dept Otolaryngol Head & Neck Surg, Sapporo, Hokkaido 0608638, Japan. RP Takagi, D (reprint author), Hokkaido Univ, Grad Sch Med, Dept Otolaryngol Head & Neck Surg, West 7,North 15, Sapporo, Hokkaido 0608638, Japan. CR Barnes PJ, 2004, LANCET, V363, P731, DOI 10.1016/S0140-6736(04)15650-X Barnes PJ, 2009, ANNU REV PHYSIOL, V71, P451, DOI 10.1146/annurev.physiol.010908.163257 Barnes PJ, 2006, CHEST, V129, P151, DOI 10.1378/chest.129.1.151 FAUCI AS, 1983, ANN INTERN MED, V98, P76 Gillespie J, 2012, ARTHRITIS RHEUM-US, V64, P418, DOI 10.1002/art.33382 Heeringa P, 2001, J PATHOL, V193, P224 Ito K, 2006, J EXP MED, V203, P7, DOI 10.1084/jem.20050466 Ito K, 2004, BIOCHEM BIOPH RES CO, V315, P240, DOI 10.1016/j.bbrc.2004.01.046 Ito K, 2005, NEW ENGL J MED, V352, P1967, DOI 10.1056/NEJMoa041892 Ito K, 2000, MOL CELL BIOL, V20, P6891, DOI 10.1128/MCB.20.18.6891-6903.2000 JENNE DE, 1990, NATURE, V346, P520, DOI 10.1038/346520a0 LEAVITT RY, 1990, ARTHRITIS RHEUM, V33, P1101 Ogryzko VV, 1996, CELL, V87, P953, DOI 10.1016/S0092-8674(00)82001-2 Roth SY, 2001, ANNU REV BIOCHEM, V70, P81, DOI 10.1146/annurev.biochem.70.1.81 Schnabel A, 2000, AM J RESP CRIT CARE, V161, P399 Tomita K, 2003, BIOCHEM BIOPH RES CO, V301, P572, DOI 10.1016/S0006-291X(02)03029-2 VANDERWOUDE FJ, 1985, LANCET, V1, P425 NR 17 TC 0 Z9 0 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD DEC PY 2012 VL 121 IS 12 BP 816 EP 820 PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA 056CX UT WOS:000312467100008 PM 23342555 ER PT J AU Nicollas, R Vicente, J Brutin, D Giordano, J Medale, M Giovanni, A Ouaknine, M Triglia, JM AF Nicollas, Richard Vicente, Jerome Brutin, David Giordano, Jerome Medale, Marc Giovanni, Antoine Ouaknine, Maurice Triglia, Jean-Michel TI The Very First Cry: A Multidisciplinary Approach Toward a Model SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE aerodynamics; false vocal fold; first cry; high-speed imaging; neonate; vocal fold ID UNILATERAL LARYNGEAL PARALYSIS; VOCAL FUNDAMENTAL-FREQUENCY; OBJECTIVE VOICE ANALYSIS; DYSPHONIC PATIENTS; ACOUSTIC ANALYSIS; FOLD VIBRATION; HUNGER CRIES; PHONATION; OPTOREFLECTOMETRY; BEHAVIOR AB Objectives: In previous work, we showed that a rigid larynx-like geometry can generate a sound by itself. However, very little is known about the exact mechanisms and control of the larynx during the first cry of life. The goal of this work was to understand how the very first cry is generated. Methods: Simultaneous high-speed imaging and sound recording on 2 excised 38-week term human fetus larynges were performed. The behaviors of the vocal folds and the false vocal folds were studied separately. The behavior of the vocal folds after resection of the supraglottic structures was also analyzed. A comparative acoustic analysis of the first cry and of the sound generated by the excised organs was performed. Results: Our data showed that the vocal folds in a larynx with the pressure conditions of the first cry do not generate sound themselves, but induce aerodynamic conditions leading to vibrations of other parts of the larynx. Conclusions: The similarities between the sound generated by an excised larynx and the first cry suggest a lack of neurologic control of the larynx during production of the first cry. A model-algorithm is proposed. C1 [Nicollas, Richard; Vicente, Jerome; Brutin, David; Giordano, Jerome; Medale, Marc] Univ Aix Marseille 1, Univ Inst Ind & Thermal Syst, CNRS, Energet Dynam Lab IUSTI,UMR 6595, Marseille, France. [Nicollas, Richard; Giovanni, Antoine; Ouaknine, Maurice; Triglia, Jean-Michel] Univ Aix Marseille 1, Clin & Expt Audiophonol Lab, CHU Timone, Marseille, France. RP Nicollas, R (reprint author), Aix Marseille Univ, Dept Pediat Otolaryngol, La Timone Childrens Hosp, 264 Rue St Pierre, F-13385 Marseille 5, France. CR ALIPOUR F, 1995, J ACOUST SOC AM, V97, P1241, DOI 10.1121/1.412233 Alipour F, 2007, ANN OTO RHINOL LARYN, V116, P135 Ayache S, 2004, J VOICE, V18, P107, DOI 10.1016/j.jvoice.2003.07.004 Baeck HE, 2007, J VOICE, V21, P551, DOI 10.1016/j.jvoice.2006.04.003 BERKE GS, 1993, J VOICE, V7, P123, DOI 10.1016/S0892-1997(05)80341-8 Berry DA, 1996, J VOICE, V10, P129, DOI 10.1016/S0892-1997(96)80039-7 Branco A, 2005, INT J PEDIATR OTORHI, V69, P681, DOI 10.1016/j.ijporl.2005.01.002 Brown O., 2000, PEDIAT OTOLARYNGOLOG, P679 Eavy RD, 1996, LARYNX MULTIDISCIPLI, P25 Fitch WT, 2002, ANIM BEHAV, V63, P407, DOI 10.1006/anbe.2001.1912 Fort A, 1998, MED ENG PHYS, V20, P432, DOI 10.1016/S1350-4533(98)00045-9 Garrel R, 2007, J VOICE, V21, P517, DOI 10.1016/j.jvoice.2006.05.002 Garrel R, 2008, J VOICE, V22, P385, DOI 10.1016/j.jvoice.2006.10.012 Garrel R, 2007, EUR ARCH OTO-RHINO-L, V264, P1201, DOI 10.1007/s00405-007-0348-3 Gilbert HR, 1996, INT J PEDIATR OTORHI, V34, P237, DOI 10.1016/0165-5876(95)01273-7 Giovanni A, 1999, J VOICE, V13, P465, DOI 10.1016/S0892-1997(99)80002-2 Giovanni A, 1999, J VOICE, V13, P341, DOI 10.1016/S0892-1997(99)80040-X HARRIS JC, 1987, BRAIN RES, V410, P353, DOI 10.1016/0006-8993(87)90337-4 Harris TR, 1988, ASSISTED VENTILATION, P22 Hertegård Stellan, 2003, Logoped Phoniatr Vocol, V28, P133, DOI 10.1080/14015430310015246 Huon C, 1989, MED PERINATALE, P293 Insel TR, 2000, CURR OPIN NEUROBIOL, V10, P784, DOI 10.1016/S0959-4388(00)00146-X Jiang JJ, 2003, J ACOUST SOC AM, V114, P2198, DOI 10.1121/1.1610462 Joyce MP, 1999, DEV PSYCHOBIOL, V34, P109, DOI 10.1002/(SICI)1098-2302(199903)34:2<109::AID-DEV4>3.0.CO;2-T Khosla S, 2007, ANN OTO RHINOL LARYN, V116, P217 Larsson H, 2000, LARYNGOSCOPE, V110, P2117, DOI 10.1097/00005537-200012000-00028 Lind K, 2002, INT J PEDIATR OTORHI, V64, P97, DOI 10.1016/S0165-5876(02)00024-1 Maunsell R, 2006, OTOLARYNG HEAD NECK, V135, P438, DOI 10.1016/j.otohns.2006.05.023 Michelsson K, 2002, FOLIA PHONIATR LOGO, V54, P190, DOI 10.1159/000063190 Nazarian A, 2001, EUR J PHARMACOL, V415, P165 Newman JD, 2007, BEHAV BRAIN RES, V182, P155, DOI 10.1016/j.bbr.2007.02 Nicollas R, 2006, BIOMED SIGNAL PROCES, V1, P102, DOI 10.1016/j.bspc.2006.08.003 Nicollas R, 2008, J VOICE, V22, P671, DOI 10.1016/j.jvoice.2007.01.009 Nicollas R, 2009, MED ENG PHYS, V31, P547, DOI 10.1016/j.medengphy.2008.08.009 Ouaknine M, 2003, FOLIA PHONIATR LOGO, V55, P28, DOI 10.1159/000068058 Praud JP, 2005, RESP PHYSIOL NEUROBI, V149, P131, DOI 10.1016/j.resp.2005.04.020 SATO K, 1995, ANN OTO RHINOL LARYN, V104, P556 STORY BH, 1995, J ACOUST SOC AM, V97, P1249, DOI 10.1121/1.412234 Svec JG, 2007, ANN OTO RHINOL LARYN, V116, P172 Thach BT, 2007, PULM PHARMACOL THER, V20, P365, DOI 10.1016/j.pupt.2006.11.011 Yu P, 2007, FOLIA PHONIATR LOGO, V59, P20, DOI 10.1159/000096547 Yu P, 2001, J VOICE, V15, P529, DOI 10.1016/S0892-1997(01)00053-4 Zeskind PS, 1996, INFANT BEHAV DEV, V19, P497, DOI 10.1016/S0163-6383(96)90009-0 NR 43 TC 0 Z9 0 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD DEC PY 2012 VL 121 IS 12 BP 821 EP 826 PG 6 WC Otorhinolaryngology SC Otorhinolaryngology GA 056CX UT WOS:000312467100009 PM 23342556 ER PT J AU Laccourreye, O Benkhatar, H Menard, M AF Laccourreye, Ollivier Benkhatar, Hakim Menard, Madeleine TI Lack of Adverse Events After Medialization Laryngoplasty With the Montgomery Thyroplasty Implant in Patients With Unilateral Laryngeal Nerve Paralysis SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE larynx; medialization laryngoplasty; paralysis ID ARYTENOID ADDUCTION; I THYROPLASTY; ENDOTRACHEAL INTUBATION; AIRWAY COMPLICATIONS; NATIONAL-SURVEY; PHONOSURGERY AB Objectives: We sought to document the incidence of and risk factors for adverse events after medialization laryngoplasty with Montgomery implant insertion in patients with unilateral laryngeal nerve paralysis. Methods: We studied a retrospective series of 191 patients consecutively managed at a university teaching hospital. Results: No adverse events were noted in 79.8% of the patients. Intraoperative, immediate, and late postoperative adverse events were noted in 8.3%, 8.9%, and 4.1% of the patients, respectively. The various adverse events noted were failure to insert the implant (3.6%), difficulties in stabilizing the implant (4.8%), misplacement of the implant (2.1%), dyspnea (2.7%), hematoma (4.8%), extrusion (1.6%), persistent morphological laryngeal alterations (1.6%), and keloid scars (1.1%). Tracheotomy, procedure-related death, and infection at the insertion site were not encountered. No significant statistical relationship was noted between the various adverse events encountered and the variables under analysis. Conclusions: Our data demonstrate that medialization laryngoplasty with Montgomery implant insertion in patients with unilateral laryngeal nerve paralysis from various causes is a relatively safe, reliable, and reproducible procedure with a short learning curve. C1 [Laccourreye, Ollivier; Benkhatar, Hakim; Menard, Madeleine] Univ Paris Descartes Sorbonne Paris Cite, HEGP, AP HP, Dept Otorhinolaryngol Head & Neck Surg, F-75015 Paris, France. RP Laccourreye, O (reprint author), Univ Paris Descartes Sorbonne Paris Cite, HEGP, AP HP, Dept Otorhinolaryngol Head & Neck Surg, 20-40 Rue Leblanc, F-75015 Paris, France. FU Progres 2000 association FX The authors are grateful to the Progres 2000 association for its financial and technical support, as well as to the following otorhinolaryngologists-head and neck surgeons - Daniel Brasnu, Erwan de Mones, Aude Francois, Nicolas Hacquart, Stephane Hans, Frederic Lagarde, Haitham Mirghani, Jean-Francois Papon, and Virginie Tissot - for allowing us to analyze their patient files and operative charts in addition to those of Drs Laccourreye and Menard. CR Abraham MT, 2001, LARYNGOSCOPE, V111, P1322, DOI 10.1097/00005537-200108000-00003 Anderson TD, 2003, J VOICE, V17, P442, DOI 10.1067/S0892-1997(03)00080-8 Ayala MA, 2007, ANN OTO RHINOL LARYN, V116, P262 Bray D, 2008, J LARYNGOL OTOL, V122, P715, DOI 10.1017/S0022215108002144 Cohen JT, 2004, OTOLARYNG HEAD NECK, V131, P236, DOI 10.1016/j.otohns.2004.03.023 Cotter CS, 1995, OTOLARYNG HEAD NECK, V113, P671, DOI 10.1016/S0194-5998(95)70003-X Friedlander P, 1999, ANN OTO RHINOL LARYN, V108, P735 Hirano M, 1993, HISTOLOGICAL COLOR A, P22 Hunsaker DH, 1995, OTOLARYNG HEAD NECK, V113, P782, DOI 10.1016/S0194-5998(95)70021-8 ISSHIKI N, 1974, ACTA OTO-LARYNGOL, V78, P451, DOI 10.3109/00016487409126379 KOUFMAN JA, 1991, OTOLARYNG CLIN N AM, V24, P1151 Laccourreye O, 2003, ANN OTO RHINOL LARYN, V112, P962 Laccourreye O, 2005, LARYNGOSCOPE, V115, P1411, DOI 10.1097/01.mlg.0000168059.12949.a6 Lam PKY, 2007, OTOLARYNG HEAD NECK, V136, P440, DOI 10.1016/j.otohns.2006.11.009 Lin HW, 2009, LARYNGOSCOPE, V119, P675, DOI 10.1002/lary.20156 Maragos NE, 1998, J VOICE, V12, P107, DOI 10.1016/S0892-1997(98)80082-9 McLean-Muse A, 2000, ANN OTO RHINOL LARYN, V109, P393 Montgomery WW, 1997, ANN OTO RHINOL LARYN, V106, P1 MONTGOMERY WW, 1993, ANN OTO RHINOL LARYN, V102, P571 NETTERVILLE JL, 1993, ANN OTO RHINOL LARYN, V102, P413 Nouwen J, 2004, ACTA OTO-LARYNGOL, V124, P732, DOI 10.1080/00016480310016875 Rosen CA, 1998, LARYNGOSCOPE, V108, P1697, DOI 10.1097/00005537-199811000-00020 Rosen CA, 1999, J VOICE, V13, P417, DOI 10.1016/S0892-1997(99)80047-2 TUCKER HM, 1993, LARYNGOSCOPE, V103, P525 Young VN, 2010, LARYNGOSCOPE, V120, P1602, DOI 10.1002/lary.21004 NR 25 TC 3 Z9 3 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD NOV PY 2012 VL 121 IS 11 BP 701 EP 707 PG 7 WC Otorhinolaryngology SC Otorhinolaryngology GA 042JR UT WOS:000311468000001 PM 23193901 ER PT J AU Paul, BC Rafii, B Achlatis, S Amin, MR Branski, RC AF Paul, Benjamin C. Rafii, Benjamin Achlatis, Stratos Amin, Milan R. Branski, Ryan C. TI Morbidity and Patient Perception of Flexible Laryngoscopy SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE laryngoscopy; larynx; morbidity; risk; voice ID GUIDELINE HOARSENESS DYSPHONIA; LARYNGEAL PROCEDURES; OFFICE; SURGERY; TOLERANCE; PARALYSIS AB Objectives: The recently published Clinical Practice Guideline: Hoarseness (Dysphonia) revealed major deficits in the literature regarding relatively routine clinical decision-making. One of the more controversial points in the Guideline regarded the utility and timing of laryngeal visualization via flexible laryngoscopy, potentially because of sparse literature regarding the risks and potential morbidity. We sought to prospectively address this issue in order to optimize evaluation protocols. Methods: Two-hundred fifty consecutive patients with a variety of complaints completed a survey after undergoing flexible laryngoscopy. The survey queried 1) demographics; 2) discomfort of pretreatment anesthesia and scope placement in the nose and pharynx; 3) fear of future examinations; and 4) patient perception and past experience. Concurrently, the laryngoscopist reported the complications and anatomic variations encountered. Results: The discomfort and pain ratings from both the anesthetic spray and the scope placement were low. No statistically significant differences were observed with regard to sex; however, women reported greater fear associated with examinations (p = 0.0001). Anatomic abnormalities were observed in 14.4% of patients, and these patients reported greater discomfort, pain, and fear regarding the examination. No adverse events were observed. Conclusions: Flexible laryngoscopy was well tolerated, with little to no risk. The presence of nasal anatomic abnormalities predicted increased discomfort. C1 [Paul, Benjamin C.; Rafii, Benjamin; Achlatis, Stratos; Amin, Milan R.; Branski, Ryan C.] NYU, Sch Med, Voice Ctr, Dept Otolaryngol, New York, NY 10016 USA. RP Branski, RC (reprint author), NYU, Sch Med, Voice Ctr, Dept Otolaryngol, 345 E 37th St,Suite 306, New York, NY 10016 USA. CR Barlesi F, 2003, REV MAL RESPIR, V20, P335 Chhetri DK, 2002, OTOLARYNG HEAD NECK, V126, P642, DOI 10.1067/mhn.2002.125604 Cohen MA, 2003, LARYNGOSCOPE, V113, P21, DOI 10.1097/00005537-200301000-00004 Coyle SM, 2001, J VOICE, V15, P424, DOI 10.1016/S0892-1997(01)00043-1 Farhadi A, 2001, Diagn Ther Endosc, V7, P141, DOI 10.1155/DTE.7.141 Fleischer S, 2005, ANN OTO RHINOL LARYN, V114, P488 Franco Ramon A Jr, 2007, Curr Opin Otolaryngol Head Neck Surg, V15, P387, DOI 10.1097/MOO.0b013e3282f19ef2 HOPKINS HH, 1954, NATURE, V173, P39, DOI 10.1038/173039b0 Johns MM, 2010, OTOLARYNG HEAD NECK, V143, P175, DOI 10.1016/j.otohns.2010.05.026 Ketata W, 2011, REV PNEUMOL CLIN, V67, P136, DOI 10.1016/j.pneumo.2010.04.005 KING DR, 1972, J AM DENT ASSOC, V85, P1336 Kollár A, 1989, Cesk Otolaryngol, V38, P114 Lacoste L, 1996, THYROID, V6, P17, DOI 10.1089/thy.1996.6.17 Mouadeb DA, 2007, OTOLARYNG HEAD NECK, V137, P477, DOI 10.1016/j.otohns.2007.02.003 Roper A J, 2007, J Laryngol Otol, V121, pe11, DOI 10.1017/S002221510700878X Schwartz SR, 2009, OTOLARYNG HEAD NECK, V141, pS1, DOI 10.1016/j.otohns.2009.06.744 Sharma A, 2006, J LARYNGOL OTOL, V120, P24, DOI 10.1017/S0022215105004731 Smith KD, 2010, INT J DENT, V2010, ppii Sulica L, 2000, LARYNGOSCOPE, V110, P1777, DOI 10.1097/00005537-200010000-00040 WHITE JF, 1984, LARYNGOSCOPE, V94, P1166 Woo P, 2006, OTOLARYNG CLIN N AM, V39, P111, DOI 10.1016/j.otc.2005.11.008 Young VN, 2012, LARYNGOSCOPE, V122, P315, DOI 10.1002/lary.22185 Zeitels Steven M, 2007, Curr Opin Otolaryngol Head Neck Surg, V15, P394, DOI 10.1097/MOO.0b013e3282f1fbb2 NR 23 TC 9 Z9 9 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD NOV PY 2012 VL 121 IS 11 BP 708 EP 713 PG 6 WC Otorhinolaryngology SC Otorhinolaryngology GA 042JR UT WOS:000311468000002 PM 23193902 ER PT J AU Morrison, MP O'Rourke, A Dion, GR Eller, RL Weinberger, P Postma, GN AF Morrison, Michele P. O'Rourke, Ashli Dion, Gregory R. Eller, Robert L. Weinberger, Paul Postma, Gregory N. TI Hemodynamic Changes During Otolaryngological Office-Based Flexible Endoscopic Procedures SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article; Proceedings Paper CT Meeting of the American-Broncho-Esophagological-Association CY APR 18-19, 2012 CL San Diego, CA SP Amer Broncho Esophagol Assoc DE endoscopy; hypertension; larynx; laser; office-based surgery; tachycardia ID LARYNGEAL PROCEDURES; LASER-SURGERY; MORTALITY AB Objectives: A preponderance of literature supports the safety of office-based flexible endoscopic procedures of the upper aerodigestive tract; however, until recently there were no data regarding hemodynamic stability during these procedures. A recent study showed intraprocedure changes in patients' hemodynamic parameters, raising the concern that perhaps patients should be monitored during these procedures. The aim of our study was to determine whether physiologically significant alterations in vital signs occur during office-based flexible endoscopic procedures. Methods: We performed a retrospective review of 100 consecutive patients who underwent office-based flexible endoscopic procedures of the upper aerodigestive tract from July 2010 to October 2011. Baseline values and the maximal changes in systolic blood pressure, diastolic blood pressure, heart rate, and oxygen saturation were recorded and compared. Results: One hundred consecutive patients were included in the study. Twenty-one patients (21%) had severe hypertension and 40 patients (40%) had tachycardia during the procedure. The mean change overall in systolic blood pressure was 26.2 mm Hg (p < 0.001), the mean change in diastolic blood pressure was 13.9 mm Hg (p < 0.001), the mean change in heart rate was 16.6 beats per minute (p < 0.001), and the mean change in oxygen saturation was 1.6% (p < 0.001). These changes were significant. On further breakdown into groups, patients over 50 years of age and patients who were undergoing esophageal or laser procedures had significant elevations in heart rate (p = 0.01 and p = 0.04, respectively). An elevation in diastolic blood pressure was also significant in patients who were undergoing esophageal or laser procedures (p = 0.04 for both). Conclusions: These data concur with those of the previous report that found potentially significant hemodynamic changes during office-based procedures. Although preliminary, our findings suggest that it may be wise to monitor vital signs in patients over 50 years of age and patients who are undergoing an esophageal or laser procedure who are at risk for complications that could arise from tachycardia and hypertension. C1 [Morrison, Michele P.; O'Rourke, Ashli; Weinberger, Paul; Postma, Gregory N.] Georgia Hlth Sci Univ, Dept Otolaryngol Head & Neck Surg, Voice Airway & Swallowing Ctr, Augusta, GA USA. [Dion, Gregory R.; Eller, Robert L.] Brooke Army Med Ctr, Dept Otolaryngol Head & Neck Surg, San Antonio, TX USA. RP Morrison, MP (reprint author), USN, Med Ctr Portsmouth, 620 John Paul Jones Circle, Portsmouth, VA 23708 USA. RI Weinberger, Paul/B-7007-2008 OI Weinberger, Paul/0000-0002-5885-2631 CR Bove MJ, 2007, LARYNGOSCOPE, V117, P226, DOI 10.1097/01.mlg.0000250898.82268.39 Cho S, 2008, CAN J GASTROENTEROL, V22, P243 Dorresteijn JAN, 2012, HYPERTENSION, V59, P14, DOI 10.1161/HYPERTENSIONAHA.111.179143 Fleisher LA, 2008, CIRCULATION, V118, pE143, DOI 10.1161/CIRCULATIONAHA.108.190757 Halum SL, 2010, J VOICE, V24, P750, DOI 10.1016/j.jvoice.2009.04.005 Koufman JA, 2007, OTOLARYNG HEAD NECK, V137, P146, DOI 10.1016/j.otohns.2007.02.041 Lindstrom DR, 2003, ARCH OTOLARYNGOL, V129, P847, DOI 10.1001/archotol.129.8.847 Mashour GA, 2011, ANESTHESIOLOGY, V114, P1289, DOI 10.1097/ALN.0b013e318216e7f4 Postma GN, 2005, LARYNGOSCOPE, V115, P321, DOI 10.1097/01/mlg.0000154741.25443.fe Rees CJ, 2007, ANN OTO RHINOL LARYN, V116, P45 Rees CJ, 2009, ARCH OTOLARYNGOL, V135, P781, DOI 10.1001/archoto.2009.115 Varon Joseph, 2008, Vasc Health Risk Manag, V4, P615 Woo P, 2006, OTOLARYNG CLIN N AM, V39, P111, DOI 10.1016/j.otc.2005.11.008 Young VN, 2012, LARYNGOSCOPE, V122, P315, DOI 10.1002/lary.22185 Yung KC, 2010, LARYNGOSCOPE, V120, P2231, DOI 10.1002/lary.21135 NR 15 TC 0 Z9 0 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD NOV PY 2012 VL 121 IS 11 BP 714 EP 718 PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA 042JR UT WOS:000311468000003 PM 23193903 ER PT J AU Shikani, AH Kourelis, K Rohayem, Z Basaraba, RJ Leid, JG AF Shikani, Alan H. Kourelis, Konstantinos Rohayem, Ziad Basaraba, Randall J. Leid, Jeff G. TI Topical Gel Therapy for Sinonasal Polyposis in Samter's Triad: Preliminary Report SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article; Proceedings Paper CT Annual Meeting of the American-Academy-of-Otolaryngology-Head-and-Neck-Surgery-Foundation and OTO EXPO CY SEP 10-14, 2011 CL San Francisco, CA SP Amer Acad Otolaryngol Head & Neck Surg Fdn DE antibiotic; corticosteroid; medication-releasing gel; multimodal topical therapy; Samter's triad; sinonasal polyposis ID ENDOSCOPIC SINUS SURGERY; CHRONIC RHINOSINUSITIS; INTRANASAL CORTICOSTEROIDS; DRUG-DELIVERY; BIOFILMS; ASTHMA; ASPIRIN AB Objectives: Rhinosinusitis and polyposis are difficult to treat in patients with Samter's triad; they commonly recur despite sinus surgery, antibiotics, and/or nasal steroids. The present study assesses the efficacy of a multimodal regimen that includes topical corticosteroids and antibiotics delivered through a hydroxyethyl cellulose gel and by nebulization. Methods: Eleven patients with Samter's triad who had polyposis and rhinosinusitis that recurred despite endoscopic sinus surgery were treated with a 6-week course of multimodal topical therapy consisting of a hydroxyethyl cellulose gel that releases corticosteroids and antibiotics, topical nebulization of corticosteroids and antibiotics, saline solution rinses, and sinus debridement. Clinical outcomes were evaluated by Lund-Kennedy endoscopic and symptom scores. Histologic assessment was evaluated by hematoxylin and eosin staining before and after treatment. Results: Both Lund-Kennedy symptom and endoscopic scores showed a progressive and statistically significant decline throughout the course of treatment, reaching at 6 weeks 42% of the pretreatment values (p = 0.005) for the Lund-Kennedy symptom score and 34% (p = 0.002) for the endoscopic score, respectively; however, the significance of the improvement was lost with time. Conclusions: Topical gel therapy improves clinical symptoms, endoscopic findings, and sinus membrane histologic features in patients with refractory Samter's triad, but the improvement is transient, suggesting that a longer therapeutic period might be needed. C1 [Shikani, Alan H.] Union Mem Hosp, Dept Otolaryngol Head & Neck Surg, Div Rhinol, Baltimore, MD 21218 USA. [Shikani, Alan H.] Johns Hopkins Med Inst, Dept Otolaryngol Head & Neck Surg, Baltimore, MD 21205 USA. [Basaraba, Randall J.] Colorado State Univ, Dept Microbiol Immunol & Pathol, Ft Collins, CO 80523 USA. [Leid, Jeff G.] No Arizona Univ, Dept Biol Sci, Flagstaff, AZ 86011 USA. RP Shikani, AH (reprint author), Union Mem Hosp, Dept Otolaryngol Head & Neck Surg, Div Rhinol, 201 E Univ Pkwy, Baltimore, MD 21218 USA. CR Bachert C, 2006, CURR OPIN ALLERGY CL, V6, P29, DOI 10.1097/01.all.0000200504.54425.0e DAHLEN B, 1993, EUR RESPIR J, V6, P1018 Demoly P, 2008, AM J OTOLARYNG, V29, P403, DOI 10.1016/j.amjoto.2007.11.004 Derendorf H, 2008, ALLERGY, V63, P1292, DOI 10.1111/j.1398-9995.2008.01750.x GLIKLICH RE, 1995, OTOLARYNG HEAD NECK, V113, P104, DOI 10.1016/S0194-5998(95)70152-4 Harvey Richard J, 2009, Otolaryngol Clin North Am, V42, P829, DOI 10.1016/j.otc.2009.07.005 Harvey RJ, 2009, OTOLARYNGOL CLIN N A, V42, pix Hekiert AM, 2009, OTOLARYNG HEAD NECK, V141, P448, DOI 10.1016/j.otohns.2009.06.090 Hilton C, 2008, AM J RHINOL, V22, P395, DOI 10.2500/ajr.2008.22.3192 Jankowski R, 2002, RHINOLOGY, V40, P173 Kamani T, 2011, CURR OPIN OTOLARYNGO, V19, P6, DOI 10.1097/MOO.0b013e328341e273 Kaplan BA, 2004, AM J RHINOL, V18, P161 Kilty SJ, 2009, IMMUNOL ALLERGY CLIN, V29, P645, DOI 10.1016/j.iac.2009.07.005 Kim JE, 2007, ENT-EAR NOSE THROAT, V86, P396 Lim M, 2008, AM J RHINOL, V22, P381, DOI 10.2500/ajr.2008.22.3189 Lund VJ, 1997, OTOLARYNG HEAD NECK, V117, pS35, DOI 10.1016/S0194-5998(97)70005-6 Mastalerz L, 1997, ALLERGY, V52, P895, DOI 10.1111/j.1398-9995.1997.tb01248.x Miller TR, 2004, LARYNGOSCOPE, V114, P201, DOI 10.1097/00005537-200402000-00004 Moller W, 2010, EXPERT OPIN DRUG DEL, V7, P1239, DOI 10.1517/17425247.2010.523078 Palmer James N, 2003, Curr Opin Otolaryngol Head Neck Surg, V11, P6, DOI 10.1097/00020840-200302000-00002 Pearlman AN, 2009, AMJ RHINOL ALLERGY, V23, P145, DOI 10.2500/ajra.2009.23.3284 Shikani A, EAR NOSE TH IN PRESS Shikani AH, 2010, CLIN OTOLARYNGOL, V35, P329, DOI 10.1111/j.1749-4486.2010.02157.x Stewart PS, 2001, LANCET, V358, P135, DOI 10.1016/S0140-6736(01)05321-1 SWEET JM, 1990, J ALLERGY CLIN IMMUN, V85, P59, DOI 10.1016/0091-6749(90)90222-P Ugwoke MI, 2005, ADV DRUG DELIVER REV, V57, P1640, DOI 10.1016/j.addr.2005.07.009 Widal F, 1993, ALLERGY PROC, V14, P371 Zhang Z, 2009, AM J RHINOL ALLERGY, V23, P506, DOI 10.2500/ajra.2009.23.3376 NR 28 TC 1 Z9 1 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD NOV PY 2012 VL 121 IS 11 BP 719 EP 724 PG 6 WC Otorhinolaryngology SC Otorhinolaryngology GA 042JR UT WOS:000311468000004 PM 23193904 ER PT J AU Gomez-Rivera, F Cattano, D Ramaswamy, U Patel, CB Altamirano, A Man, LX Luong, A Chen, ZX Citardi, MJ Fakhri, S AF Gomez-Rivera, Fernando Cattano, Davide Ramaswamy, Uma Patel, Chirag B. Altamirano, Alfonso Man, Li-Xing Luong, Amber Chen, Zhongxue Citardi, Martin J. Fakhri, Samer TI Pilot Study Comparing Total Intravenous Anesthesia to Inhalational Anesthesia in Endoscopic Sinus Surgery: Novel Approach of Blood Flow Quantification SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE chronic rhinosinusitis; endoscopic sinus surgery; optical rhinometry; total intravenous anesthesia ID MODERATE CONTROLLED HYPOTENSION; IMPROVE SURGICAL CONDITIONS; SODIUM-NITROPRUSSIDE; OPTICAL RHINOMETRY; PROPOFOL; FIELD; MICROCIRCULATION; EPINEPHRINE; SEVOFLURANE AB Objectives: We compared anesthesia with sevoflurane-remifentanil hydrochloride (SR) to total intravenous anesthesia with propofol remifentanil hydrochloride (PR) in patients undergoing endoscopic sinus surgery for chronic rhinosinusitis in terms of sinonasal mucosal blood flow, the surgical field visualization score, and blood loss. Methods: We performed a double-blinded prospective study at a tertiary care center in 23 adults scheduled to undergo endoscopic sinus surgery for chronic rhinosinusitis. The patients were randomized to receive SR or PR. The sinonasal mucosal blood flow was measured by optical rhinometry. The surgical field visualization score was based on the Boezaart scale. Results: The groups had similar clinical characteristics. During the 60- to 90-minute and 90- to 120-minute operative time windows, the blood flow was significantly greater in the PR group than in the SR group (p = 0.04 and p = 0.03, respectively). The amounts of blood loss in the PR and SR groups were 152.9 +/- 161.3 mL and 355.9 +/- 393.4 mL, respectively (p = 0.12). The median ratios of the surgical field visualization score to the number of sinuses operated on in the PR and SR groups were 2.1 and 1.8, respectively (p = 0.52). Conclusions: The intraoperative blood flow, as determined by optical rhinometry, was significantly greater with anesthesia with PR than with anesthesia with SR, 1 hour into the procedure; however, this difference did not translate into differences in the amounts of operative blood loss or in the surgical field visualization scores. C1 [Gomez-Rivera, Fernando; Ramaswamy, Uma; Patel, Chirag B.; Luong, Amber; Citardi, Martin J.; Fakhri, Samer] Univ Texas Med Sch Houston, Dept Otorhinolaryngol Head & Neck Surg, Houston, TX 77030 USA. [Cattano, Davide; Altamirano, Alfonso] Univ Texas Med Sch Houston, Dept Anesthesiol, Houston, TX 77030 USA. [Chen, Zhongxue] Univ Texas Med Sch Houston, Ctr Clin & Translat Sci, Houston, TX 77030 USA. [Man, Li-Xing] Univ Rochester, Dept Otolaryngol, Rochester, NY USA. RP Fakhri, S (reprint author), Univ Texas Med Sch Houston, Dept Otorhinolaryngol Head & Neck Surg, 6431 Fannin St,MSB 5-036, Houston, TX 77030 USA. RI Chen, Zhongxue/K-1372-2013 OI Chen, Zhongxue/0000-0003-2537-7843 CR Ahn HJ, 2008, BRIT J ANAESTH, V100, P50, DOI 10.1093/bja/aem304 Albertin A, 2008, SPINE, V33, P2017, DOI 10.1097/BRS.0b013e31817e0405 Athanasiadis T, 2008, LARYNGOSCOPE, V118, P314, DOI 10.1097/MLG.0b013e318157f764 BLACKWELL KE, 1993, AM J OTOLARYNG, V14, P262, DOI 10.1016/0196-0709(93)90072-F Boezaart AP, 2001, J CLIN ANESTH, V13, P319, DOI 10.1016/S0952-8180(01)00247-1 BOEZAART AP, 1995, CAN J ANAESTH, V42, P373 Cheung EJ, 2010, OTOLARYNG HEAD NECK, V143, P290, DOI 10.1016/j.otohns.2010.02.034 Eberhart LHJ, 2003, LARYNGOSCOPE, V113, P1369, DOI 10.1097/00005537-200308000-00019 Gelb AW, 1996, ANESTH ANALG, V83, P472, DOI 10.1097/00000539-199609000-00005 Hampel U, 2004, IEEE T BIO-MED ENG, V51, P1673, DOI 10.1109/TBME.2004.827939 Higgins TS, 2011, LARYNGOSCOPE, V121, P422, DOI 10.1002/lary.21286 HOLZMANN A, 1995, BRIT J ANAESTH, V75, P452 Jacobi KE, 2000, J CLIN ANESTH, V12, P202, DOI 10.1016/S0952-8180(00)00145-8 Javer AR, 2009, AMJ RHINOL ALLERGY, V23, P437, DOI 10.2500/ajra.2009.23.3339 Koch M, 2008, BRIT J ANAESTH, V101, P473, DOI 10.1093/bja/aen210 Kupferberg SB, 1997, OTOLARYNG HEAD NECK, V117, P35, DOI 10.1016/S0194-5998(97)70203-1 Lund Valerie J., 1993, Rhinology (Utrecht), V31, P183 Luong A, 2010, OTOLARYNG HEAD NECK, V143, P284, DOI 10.1016/j.otohns.2010.03.030 Mittenzwey H, 2007, PEDIATR ALLERGY IMMU, V18, P372, DOI 10.1111/j.1399-3038.2007.00530.x Mortuaire G, 2008, RHINOLOGY, V46, P285 Moshaver A, 2009, ARCH OTOLARYNGOL, V135, P1005, DOI 10.1001/archoto.2009.144 Nekhendzy V, 2007, ANESTH ANALG, V105, P1404, DOI 10.1213/01.ane.0000282781.56025.52 Pagel PS, 2005, MILLERS ANESTHESIA, P191 Pavlin JD, 1999, AM J OTOLARYNG, V20, P96, DOI 10.1016/S0196-0709(99)90018-2 Wormald PJ, 2005, AM J RHINOL, V19, P514 Wustenberg EG, 2006, HNO, V54, P99, DOI 10.1007/s00106-005-1301-7 NR 26 TC 3 Z9 3 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD NOV PY 2012 VL 121 IS 11 BP 725 EP 732 PG 8 WC Otorhinolaryngology SC Otorhinolaryngology GA 042JR UT WOS:000311468000005 PM 23193905 ER PT J AU Meacham, R Vieira, F AF Meacham, Ryan Vieira, Francisco TI Is Obesity Truly a Risk Factor for Mortality After Tracheotomy? SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article; Proceedings Paper CT Meeting of the American-Broncho-Esophagological-Association CY APR 18-19, 2012 CL San Diego, CA SP Amer Broncho Esophagol Assoc DE comorbidity; mortality; obesity; tracheotomy ID MORBIDLY OBESE; PERCUTANEOUS TRACHEOSTOMY; COMPLICATIONS AB Objectives: We sought to determine the short-term and long-term overall mortality rates in obese and non-obese patients after tracheotomy and to evaluate which factors, including the Charlson Comorbidity Index (CCI), predict mortality rates among obese patients. Methods: We performed a retrospective chart review of patients who underwent open tracheotomy in the operating room at a single hospital from 2005 to 2010. Results: Of 200 patients reviewed, 146 were non-obese and 54 were obese. The rate of mortality was higher at 30 clays (p = 0.02) and at 1 year (p = 0.04) in obese patients (35.1% and 59.2%, respectively) than in non-obese patients (19.2% and 42.5%, respectively). The need for tracheotomy due to ventilator-dependent respiratory failure (VDRF) was much higher (p < 0.001) in obese patients (83.3%) than in non-obese patients (56.8%), and the rate of mortality was significantly higher (p < 0.001) in those who required tracheotomy for VDRF (32.8% at 30 days and 57% at I year) than in those who required tracheotomy for all other indications (4.2% at 30 clays and 25% at 1 year). The mortality risk increased with higher CCI scores at both 30 clays (p = 0.08) and 1 year (p = 0.009). Conclusions: The overall mortality rate is higher in obese patients after tracheotomy than in non-obese control subjects in the short and long terms. This increased rate of mortality is due to the heightened incidence of tracheotomy for VDRF among obese patients. The mortality rates after tracheotomy correlate well with the CCI. C1 [Meacham, Ryan; Vieira, Francisco] Univ Tennessee, Hlth Sci Ctr, Dept Otolaryngol, Memphis, TN USA. RP Vieira, F (reprint author), 910 Madison Ave,Suite 430, Memphis, TN 38163 USA. CR Byhahn C, 2005, ANAESTHESIA, V60, P12, DOI 10.1111/j.1365-2044.2004.03707.x CHARLSON ME, 1987, J CHRON DIS, V40, P373, DOI 10.1016/0021-9681(87)90171-8 Darrat I, 2008, LARYNGOSCOPE, V118, P2125, DOI 10.1097/MLG.0b013e3181847a78 El Solh AA, 2007, CRIT CARE, V11, DOI 10.1186/cc5147 GHORAYEB BY, 1987, ARCH OTOLARYNGOL, V113, P556 Gross ND, 2002, LARYNGOSCOPE, V112, P1940, DOI 10.1097/00005537-200211000-00006 Halum SL, 2012, LARYNGOSCOPE, V122, P38, DOI 10.1002/lary.22364 Heyrosa MG, 2006, J AM COLL SURGEONS, V202, P618, DOI 10.1016/j.jamcollsurg.2005.12.009 KRAL JG, 1985, ANN INTERN MED, V103, P1043 Shah RK, 2012, LARYNGOSCOPE, V122, P25, DOI 10.1002/lary.21907 Wang Y, 2007, EPIDEMIOL REV, V29, P6, DOI 10.1093/epirev/mxm007 NR 11 TC 2 Z9 2 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD NOV PY 2012 VL 121 IS 11 BP 733 EP 737 PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA 042JR UT WOS:000311468000006 PM 23193906 ER PT J AU Gullung, JL Hill, EG Castell, DO Martin-Harris, B AF Gullung, Jessica L. Hill, Elizabeth G. Castell, Donald O. Martin-Harris, Bonnie TI Oropharyngeal and Esophageal Swallowing Impairments: Their Association and the Predictive Value of the Modified Barium Swallow Impairment Profile and Combined Multichannel Intraluminal Impedance-Esophageal Manometry SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article; Proceedings Paper CT Meeting of the American-Broncho-Esophagological-Association CY APR 18-19, 2012 CL San Diego, CA SP Amer Broncho Esophagol Assoc DE deglutition; dysphagia; manometry; MBSImP; modified barium swallow study; swallowing ID GASTROESOPHAGEAL-REFLUX; PHARYNGEAL SWALLOW; DYSPHAGIA PATIENTS; BOLUS; INTERRELATIONSHIPS; ABNORMALITIES; ASPIRATION; CLEARANCE; MOTILITY AB Objectives: Deglutition is a highly integrated process of neural signaling and coordinated muscular contraction that begins with bolus preparation in the oral cavity and ends with closure of the lower esophageal sphincter after bolus passage. The goal of this study was to examine the relationship between measures of oropharyngeal and esophageal swallow function. Methods: A retrospective review was performed of patients who underwent modified barium swallow study (MBSS) and multichannel intraluminal impedance-esophageal manometry (MII-EM) over 7 years at an academic institution. The MBSS was scored with the Modified Barium Swallow Impairment Profile (MBSImP). Associations between impairments as measured by the MBSImP and MII-EM were assessed with a 2-sided Fisher's exact test. Results: One hundred sixty-four patients met the inclusion criteria for the study. Comparison of MBSImP component and oral and pharyngeal total regional scores to MII-EM scores revealed a significant association between abnormal esophageal clearance on MBSS (MBSImP component 17) and abnormal findings on MII-EM (p < 0.001). Delay in initiation of pharyngeal swallow (MBSImP component 6) was significantly associated with abnormal esophageal clearance on MBSS (p = 0.023). Conclusions: Abnormal esophageal clearance on MBSS (MBSImP component 17) indicates a need for further esophageal testing. A functional interrelationship between abnormalities of oropharyngeal and esophageal swallowing does exist, illuminating the importance of thorough pharyngoesophageal examination for dysphagia symptoms. C1 [Gullung, Jessica L.; Martin-Harris, Bonnie] Med Univ S Carolina, Dept Otolaryngol Head & Neck Surg, Charleston, SC 29425 USA. [Hill, Elizabeth G.] Med Univ S Carolina, Div Biostat & Epidemiol, Charleston, SC 29425 USA. [Castell, Donald O.] Med Univ S Carolina, Div Gastroenterol Hepatol, Charleston, SC 29425 USA. [Martin-Harris, Bonnie] Med Univ S Carolina, Evelyn Trammel Inst Voice & Swallowing, Charleston, SC 29425 USA. RP Gullung, JL (reprint author), Med Univ S Carolina, Dept Otolaryngol Head & Neck Surg, 135 Rutledge Ave,MSC 550, Charleston, SC 29425 USA. CR Allen JE, 2012, HEAD NECK-J SCI SPEC, V34, P264, DOI 10.1002/hed.21727 BUCHHOLZ DW, 1985, GASTROINTEST RADIOL, V10, P235, DOI 10.1007/BF01893106 Cho YK, 2012, DIS ESOPHAGUS, V25, P17, DOI 10.1111/j.1442-2050.2011.01212.x Edwards DAW, 1974, DIS ESOPHAGUS, P103 HENDERSON RD, 1976, LARYNGOSCOPE, V86, P1531, DOI 10.1288/00005537-197610000-00007 Jones B, 1987, Dysphagia, V2, P87, DOI 10.1007/BF02408139 JONES B, 1985, GASTROINTEST RADIOL, V10, P225, DOI 10.1007/BF01893105 KAHRILAS PJ, 1992, GASTROENTEROLOGY, V103, P128 Katz PO, 2008, J CLIN GASTROENTEROL, V42, P620, DOI 10.1097/MCG.0b013e3181653a5c Knight RE, 2000, LARYNGOSCOPE, V110, P1462, DOI 10.1097/00005537-200009000-00010 Kuhlemeier KV, 2001, DYSPHAGIA, V16, P119, DOI 10.1007/s004550011003 Lee KL, 2012, AM J PHYS MED REHAB, V91, P187, DOI 10.1097/PHM.0b013e318238a0e3 Logemann JA, 2007, BEST PRACT RES CL GA, V21, P563, DOI 10.1016/j.bpg.2007.03.006 Martin-Harris B, 2008, DYSPHAGIA, V23, P392, DOI 10.1007/s00455-008-9185-9 Martin-Harris B, 2005, OTOLARYNG HEAD NECK, V133, P234, DOI 10.1016/j.otohns.2005.03.059 Mendell DA, 2002, DYSPHAGIA, V17, P220, DOI 10.1007/s00455-002-0056-5 Northern Speech Services, STAND MBSS OLSSON R, 1995, ABDOM IMAGING, V20, P230, DOI 10.1007/BF00200402 Rosenstein M, 1992, HDB SELECTED TISSUE Simren M, 2003, GUT, V52, P784, DOI 10.1136/gut.52.6.784 Sivit C J, 1988, Dysphagia, V2, P151, DOI 10.1007/BF02424933 Smith DF, 1998, AM J ROENTGENOL, V171, P1361 Spechler SJ, 2001, GUT, V49, P145, DOI 10.1136/gut.49.1.145 TRIADAFILOPOULOS G, 1992, DIGEST DIS SCI, V37, P551, DOI 10.1007/BF01307579 Tutuian R, 2004, AM J GASTROENTEROL, V99, P1011, DOI 10.1111/j.1572-0241.2004.30035.x NR 25 TC 5 Z9 6 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD NOV PY 2012 VL 121 IS 11 BP 738 EP 745 PG 8 WC Otorhinolaryngology SC Otorhinolaryngology GA 042JR UT WOS:000311468000007 PM 23193907 ER PT J AU Friedman, AD Kobler, JB Landau-Zemer, T Barbu, AM Burns, JA AF Friedman, Aaron D. Kobler, James B. Landau-Zemer, Tali Barbu, Anca M. Burns, James A. TI High-Force Simulated Intubation Fails to Dislocate Cricoarytenoid Joint in Ex Vivo Human Larynges SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article; Proceedings Paper CT Meeting of the American-Broncho-Esophagological-Association CY APR 18-19, 2012 CL San Diego, CA SP Amer Broncho Esophagol Assoc DE arytenoid cartilage; dislocation; injury; intubation; vocal cord paralysis; voice disorder; wound ID ARYTENOID DISLOCATION; COMPUTED-TOMOGRAPHY; SUBLUXATION; ANESTHESIA AB Objectives: We assessed the likelihood of arytenoid dislocation during intubation through the application of controlled force. Methods: Six cadaveric human larynges were mounted in an apparatus for simulating forcible collision with the arytenoid complexes. An endotracheal tube tip probe (ETTP) was Used to push one arytenoid complex, and a non-slip probe (NSP) was tested on the other. Increasing pressure was applied until the probes either slipped or reached 5 kg of force. Dissection was then performed to assess the integrity of the cricoarytenoid ligament. The forces obtained by pushing an endotracheal tube against an electronic balance were measured to estimate the maximal possible intubating force. Results: None of the ETTP or NSP trials disrupted the cricoarytenoid joint ligaments, and the joint never appeared to be dislocated. The mean maximal forces were 1.8 kg for the ETTP (after which, slippage consistently occurred) and 4.7 kg for the NSP. The mean maximal forces from an endotracheal tube pushed against a scale were 1.5 kg (without stylet) and 4.6 kg (with stylet). Conclusions: Arytenoid dislocation did not happen, and gross disruption of the joint capsule or ligament did not occur, even when the testing approximated the maximum force achievable under extreme conditions. Endotracheal tube insertion thus seems unlikely to cause arytenoid dislocation. C1 [Burns, James A.] Massachusetts Gen Hosp, Ctr Laryngeal Surg & Voice Rehabil, Boston, MA 02114 USA. Harvard Univ, Sch Med, Dept Surg, Boston, MA 02115 USA. RP Burns, JA (reprint author), Massachusetts Gen Hosp, Ctr Laryngeal Surg & Voice Rehabil, 1 Bowdoin Sq,11th Floor, Boston, MA 02114 USA. CR Afonso A, 2011, ENDOSCOPY, V43, pE368, DOI 10.1055/s-0030-1256690 CAVO JW, 1985, LARYNGOSCOPE, V95, P1352 CLOSE LG, 1987, HEAD NECK-J SCI SPEC, V9, P341, DOI 10.1002/hed.2890090607 DUDLEY JP, 1984, ARCH OTOLARYNGOL, V110, P483 FRINK EJ, 1989, ANESTHESIOLOGY, V70, P358, DOI 10.1097/00000542-198902000-00030 Kasperbauer JL, 1998, LARYNGOSCOPE, V108, P1704, DOI 10.1097/00005537-199811000-00021 KOMORN RM, 1973, LARYNGOSCOPE, V83, P683, DOI 10.1288/00005537-197305000-00004 Leelamanit V, 2012, J LARYNGOL OTOL, V126, P168, DOI 10.1017/S002221511100226X Mau T, 2012, J VOICE, V26, P133, DOI 10.1016/j.jvoice.2010.12.004 Nerurkar N, 2012, AM J OTOLARYNG, V33, P275, DOI 10.1016/j.amjoto.2011.07.001 Norris BK, 2011, LARYNGOSCOPE, V121, P142, DOI 10.1002/lary.21276 Paulsen FP, 1999, ANESTHESIOLOGY, V91, P659, DOI 10.1097/00000542-199909000-00016 QUICK CA, 1978, ARCH OTOLARYNGOL, V104, P267 Rubin AD, 2005, J VOICE, V19, P687, DOI 10.1016/j.jvoice.2004.11.002 SATALOFF RT, 1994, LARYNGOSCOPE, V104, P1353 Senoglu Nimet, 2008, Cases J, V1, P251, DOI 10.1186/1757-1626-1-251 Wang RC, 1998, LARYNGOSCOPE, V108, P1, DOI 10.1097/00005537-199804001-00001 NR 17 TC 1 Z9 1 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD NOV PY 2012 VL 121 IS 11 BP 746 EP 753 PG 8 WC Otorhinolaryngology SC Otorhinolaryngology GA 042JR UT WOS:000311468000008 PM 23193908 ER PT J AU Maturo, S Benboujja, F Boudoux, C Hartnick, C AF Maturo, Stephen Benboujja, Fouzi Boudoux, Caroline Hartnick, Christopher TI Quantitative Distinction of Unique Vocal Fold Subepithelial Architectures Using Optical Coherence Tomography SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article; Proceedings Paper CT Meeting of the American-Broncho-Esophagological-Association CY APR 18-19, 2012 CL San Diego, CA SP Amer Broncho Esophagol Assoc DE development; maturation; pediatrics; vocal fold ID LAMINA PROPRIA; AIRWAY AB Objectives: The primary objective of this study was to quantitatively analyze ex vivo porcine, fetal human, and adult human vocal folds by use of optical coherence tomography (OCT). A secondary objective was to quantitatively discriminate among 1-, 2-, and 3-layer lamina propria structures. Methods: We performed an analysis of the vocal folds of 10 adult pig, 3 adult human, and 2 fetal human vocal fold specimens using OCT and histologic techniques. We present a quantitative comparison of the OCT results and histologic findings. Results: We found that OCT allowed for the visualization of the subepithelial vocal fold architecture of all imaged tissue, and that it revealed distinct characteristic signal intensities for each type of specimen. Conclusions: Optical coherence tomography was developed for in vivo imaging of biological microstructures. This study demonstrates the ability of OCT to differentiate between the vocal fold architectures of 3 histologically distinct types of vocal folds. Future studies aim to develop a quantitative optical imaging algorithm that can be used to facilitate an in vivo longitudinal clinical investigation of the changes that occur in this layered structure over time and maturation. C1 [Maturo, Stephen; Benboujja, Fouzi; Boudoux, Caroline; Hartnick, Christopher] Massachusetts Eye & Ear Infirm, Dept Otolaryngol, Boston, MA 02114 USA. RP Hartnick, C (reprint author), Harvard Univ, Massachusetts Eye & Ear Infirm, Sch Med, Dept Otol & Laryngol, 243 Charles St, Boston, MA 02114 USA. CR Boseley ME, 2006, ANN OTO RHINOL LARYN, V115, P784 Boudoux C, 2009, J VOICE, V23, P269, DOI 10.1016/j.jvoice.2007.10.003 Boudoux C, 2009, ARCH OTOLARYNGOL, V135, P53, DOI 10.1001/archoto.2008.518 Bunting G, 2012, ARCH OTOLARYNGOL, P1 Burns JA, 2005, ANN OTO RHINOL LARYN, V114, P671 Chauhan DS, 1999, INVEST OPHTH VIS SCI, V40, P2332 Hartnick CJ, 2005, LARYNGOSCOPE, V115, P4, DOI 10.1097/01.mlg.0000150685.54893.e9 Kaiser ML, 2009, CLIN OTOLARYNGOL, V34, P460, DOI 10.1111/j.1749-4486.2009.02005.x Kimura M, 2003, LARYNGOSCOPE, V113, P607, DOI 10.1097/00005537-200304000-00005 Nassif NA, 2005, OTOLARYNG HEAD NECK, V133, P845, DOI 10.1016/j.otohns.2005.09.013 Ridgway JM, 2008, ANN OTO RHINOL LARYN, V117, P327 Ridgway JM, 2007, LARYNGOSCOPE, V117, P2206, DOI 10.1097/MLG.0b013e318145b306 SATO K, 1995, ANN OTO RHINOL LARYN, V104, P556 Vokes DE, 2008, ANN OTO RHINOL LARYN, V117, P538 Wirbelauer C, 2002, GRAEF ARCH CLIN EXP, V240, P727, DOI 10.1007/s00417-002-0518-3 NR 15 TC 3 Z9 3 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD NOV PY 2012 VL 121 IS 11 BP 754 EP 760 PG 7 WC Otorhinolaryngology SC Otorhinolaryngology GA 042JR UT WOS:000311468000009 PM 23193909 ER PT J AU Park, MK Lee, BD Lee, JD Jung, HH Chae, SW AF Park, Moo Kyun Lee, Byung Don Lee, Jong Dae Jung, Hak Hyun Chae, Sung Won TI Gene Profiles During Vestibular Compensation in Rats After Unilateral Labyrinthectomy SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE denervation; gene expression; labyrinthectomy; microarray; vestibular nucleus ID MICROARRAY ANALYSIS; INNER-EAR; EXPRESSION; IMMUNOREACTIVITY; DEAFFERENTATION; MECHANISMS; RECOVERY; PEPTIDE; COMPLEX; NUCLEI AB Objectives: The aims of this study were to determine changes in gene expression in the chronic state of vestibular compensation by microarray analysis and to validate the asymmetrical levels of gene expression in the ipsilateral and contralateral vestibular nucleus complexes (VNCs). Methods: Microarray analysis was used to examine the expression of genes up-regulated or down-regulated in the ipsilateral VNC at 1 and 7 days after unilateral labyrinthectomy. Up-regulated or down-regulated gene expression in the ipsilateral and contralateral VNCs was then validated by reverse transcriptase polymerase chain reaction at 1, 7,14, and 28 clays after labyrinthectomy. Results: The genes down-regulated at 1 day after labyrinthectomy and up-regulated at 7 clays after labyrinthectomy as determined by microarray analysis and reverse transcriptase polymerase chain reaction were zinc finger protein 307, zinc metallopeptidase, P34, calcitonin receptor, insulin-like growth factor binding protein 5, GATA binding protein 3, and CD151. Expression of zinc finger protein 307, zinc metallopeptidase, P34, and calcitonin receptor was up-regulated even after 7 days in the contralateral VNC of rats that had labyrinthectomy. Conclusions: This study demonstrated changes in gene expression in rats during the chronic phase of vestibular compensation after unilateral labyrinthectomy and provided profiles of these changes in gene expression. C1 [Jung, Hak Hyun; Chae, Sung Won] Korea Univ, Coll Med, Dept Otolaryngol Head & Neck Surg, Seoul 152703, South Korea. [Park, Moo Kyun; Lee, Byung Don; Lee, Jong Dae] Soonchunhyang Univ, Coll Med, Dept Otolaryngol Head & Neck Surg, Seoul, South Korea. RP Chae, SW (reprint author), Korea Univ, Coll Med, Guro Hosp, Dept Otolaryngol Head & Neck Surg, 80 Guro Dong, Seoul 152703, South Korea. CR Darlington CL, 2000, PROG NEUROBIOL, V62, P313, DOI 10.1016/S0301-0082(00)00002-2 Dememes D, 1998, DEV BRAIN RES, V108, P59, DOI 10.1016/S0165-3806(98)00030-3 Espanel X, 1997, INT J DEV BIOL, V41, P469 Horii A, 2004, J NEUROCHEM, V91, P975, DOI 10.1111/j.1471-4159.2004.02781.x Kerachian MA, 2010, ARTHRITIS RES THER, V12, DOI 10.1186/ar3062 Kim MS, 2004, BRAIN RES, V1011, P238, DOI 10.1016/j.brainres.2004.03.031 Kitahara T, 1995, Acta Otolaryngol Suppl, V520 Pt 2, P401 LI HY, 1995, LARYNGOSCOPE, V105, P417, DOI 10.1288/00005537-199504000-00015 Masumura C, 2007, BRAIN RES, V1138, P129, DOI 10.1016/j.brainres.2006.12.072 OHNO K, 1993, ACTA OTO-LARYNGOL, P16 Provenano M, 2007, ADV EXP MED BIOL, V593, P66 Ramakrishnan R, 2002, NUCLEIC ACIDS RES, V30, DOI 10.1093/nar/30.7.e30 Sansom AJ, 2000, BRAIN RES, V882, P45, DOI 10.1016/S0006-8993(00)02786-4 Shepard NT, 2009, HDB CLIN AUDIOLOGY, P467 Shinder ME, 2006, J VESTIBUL RES-EQUIL, V16, P147 SMITH PF, 1989, BRAIN RES REV, V14, P155, DOI 10.1016/0165-0173(89)90013-1 Streit S, 2009, PANCREATOLOGY, V9, P577, DOI 10.1159/000212084 Tighilet B, 2001, EUR J NEUROSCI, V13, P2255, DOI 10.1046/j.0953-816x.2001.01622.x Wallis D, 2003, DEVELOPMENT, V130, P221, DOI 10.1242/dev.00190 Yardley L, 1998, BRIT J GEN PRACT, V48, P1136 NR 20 TC 1 Z9 1 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD NOV PY 2012 VL 121 IS 11 BP 761 EP 769 PG 9 WC Otorhinolaryngology SC Otorhinolaryngology GA 042JR UT WOS:000311468000010 PM 23193910 ER PT J AU Paul, BC Branski, RC Amin, MR AF Paul, Benjamin C. Branski, Ryan C. Amin, Milan R. TI Diagnosis and Management of New-Onset Hoarseness: A Survey of the American Broncho-Esophagological Association SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article; Proceedings Paper CT Meeting of the American-Broncho-Esophagological-Association CY APR 18-19, 2012 CL San Diego, CA SP Amer Broncho Esophagol Assoc DE Clinical Practice Guideline; hoarseness; laryngoscopy ID DYSPHONIA AB Objectives: The recently published Clinical Practice Guideline raised issues related to the value and timing of laryngoscopy in patients with hoarseness. We sought to determine the extent to which these guidelines concur with clinical practice among members of the American Broncho-Esophagological Association (ABEA). Methods: A web-based survey was distributed to ABEA members, composed of four sections: 1) background and demographics; 2) information regarding the appropriate length of time that new-onset dysphonia may be managed before laryngeal visualization, given particular comorbidities; 3) the frequency and risks of office-based flexible transnasal laryngoscopy; and 4) the overall value of laryngoscopy and stroboscopy. Results: Seventy-one ABEA members completed the survey; they had a combined 1,468 years of post-residency experience. Approximately 75% of respondents were involved in a fully academic practice. Across all respondents, an average of 11 patients with new voice complaints were seen per week. Overall, 98.6% of respondents believe that laryngoscopy is very valuable. Stridor in a neonate and potential foreign bodies were both conditions necessitating laryngoscopy on the day of presentation. In patients with no serious underlying condition(s), the mean duration until laryngoscopy was 12.96 days (range, 0 to 30 days). Conclusions: These data suggest that the current practice patterns among experts in the field are divergent from the recently published Guideline. C1 [Paul, Benjamin C.; Branski, Ryan C.; Amin, Milan R.] NYU, Voice Ctr, Sch Med, Dept Otolaryngol, New York, NY 10016 USA. RP Branski, RC (reprint author), NYU, Voice Ctr, Sch Med, Dept Otolaryngol, 345 E 37th St,Suite 306, New York, NY 10016 USA. CR Johns MM, 2010, OTOLARYNG HEAD NECK, V143, P175, DOI 10.1016/j.otohns.2010.05.026 Merrill RM, 2011, LARYNGOSCOPE, V121, P2004, DOI 10.1002/lary.21895 SATALOFF RT, 1991, ANN OTO RHINOL LARYN, V100, P725 Schwartz SR, 2009, OTOLARYNG HEAD NECK, V141, pS1, DOI 10.1016/j.otohns.2009.06.744 Sulica L, 2003, ANN OTO RHINOL LARYN, V112, P827 Wax MK, 2011, PRIMARY CARE OTOLARY NR 6 TC 6 Z9 6 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD OCT PY 2012 VL 121 IS 10 BP 629 EP 634 PG 6 WC Otorhinolaryngology SC Otorhinolaryngology GA 024LK UT WOS:000310110500001 PM 23130535 ER PT J AU Lee, JM Weinstein, GS O'Malley, BW Thaler, ER AF Lee, Jonathan M. Weinstein, Gregory S. O'Malley, Bert W., Jr. Thaler, Erica R. TI Transoral Robot-Assisted Lingual Tonsillectomy and Uvulopalatopharyngoplasty for Obstructive Sleep Apnea SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article; Proceedings Paper CT Meeting of the American-Broncho-Esophagological-Association CY APR 27-28, 2011 CL Chicago, IL SP Amer Broncho Esophagol Assoc DE endoscopic surgery; obstructive sleep apnea; tongue; transoral robotic surgery; uvulopalatopharyngoplasty ID SURGICAL MODIFICATIONS; UPPER AIRWAY; PRACTICE PARAMETERS; SURGERY; ADULTS; BASE AB Objectives: We assessed the use of transoral robot-assisted lingual tonsillectomy and uvulopalatopharyngoplasty for the surgical management of tongue base obstruction in patients with obstructive sleep apnea. Methods: In a prospective, nonrandomized trial using historical controls, patients underwent drug-induced sleep endoscopy, transoral robot-assisted lingual tonsillectomy with uvulopalatopharyngoplasty, and preoperative and postoperative polysomnography. Results: Twenty patients have completed the study to date. The rate of surgical success was 45%, and the rate of surgical response was 65%. The mean preoperative apnea-hypopnea index of 55.6 decreased by 56.7%, to a mean postoperative value of 24.1 (p < 0.001), and the minimum arterial oxygen saturation increased from the mean preoperative value of 75.8% to the mean postoperative value of 81.7% (p = 0.013). The mean Epworth Sleepiness Scale score improved from 13.4 to 5.9 (p = 0.003). One patient had postoperative bleeding that required cauterization, resulting in a major complication rate of 4.2%. Conclusions: Transoral robot-assisted lingual tonsillectomy with uvulopalatopharyngoplasty is a novel technique for the surgical management of obstructive sleep apnea that results in a significant decrease in the apnea-hypopnea index, a significant improvement in minimum arterial oxygen saturation, and a significant improvement in the Epworth Sleepiness Scale score and has an acceptable complication rate. C1 [Lee, Jonathan M.; Weinstein, Gregory S.; O'Malley, Bert W., Jr.; Thaler, Erica R.] Univ Penn, Perelman Sch Med, Dept Otorhinolaryngol Head & Neck Surg, Philadelphia, PA 19104 USA. RP Lee, JM (reprint author), Univ Penn, Perelman Sch Med, Dept Otorhinolaryngol Head & Neck Surg, 3400 Spruce St, Philadelphia, PA 19104 USA. CR Aurora RN, 2010, SLEEP, V33, P1408 Caples SM, 2010, SLEEP, V33, P1396 Chabolle F, 1999, LARYNGOSCOPE, V109, P1273, DOI 10.1097/00005537-199908000-00017 CROFT CB, 1991, CLIN OTOLARYNGOL, V16, P504, DOI 10.1111/j.1365-2273.1991.tb01050.x FUJITA S, 1981, OTOLARYNG HEAD NECK, V89, P923 JOHNS MW, 1991, SLEEP, V14, P540 Kezirian E., 2006, OPER TECH OTOLARYNGO, V17, P230, DOI 10.1016/j.otot.2006.10.005 Kushida CA, 2005, SLEEP, V28, P499 O'Malley BW, 2006, LARYNGOSCOPE, V116, P1465, DOI 10.1097/01.mlg.0000227184.90514.1a Sher AE, 1996, SLEEP, V19, P156 Sin DD, 2002, CHEST, V121, P430, DOI 10.1378/chest.121.2.430 Sorrenti G, 2004, Acta Otorhinolaryngol Ital, V24, P204 Vicini C, 2012, HEAD NECK-J SCI SPEC, V34, P15 Weinstein GS, 2007, ARCH OTOLARYNGOL, V133, P1220, DOI 10.1001/archotol.133.12.1220 Weinstein GS, 2010, ARCH OTOLARYNGOL, V136, P1079, DOI 10.1001/archoto.2010.191 Weinstein GS, 2005, LARYNGOSCOPE, V115, P1315, DOI 10.1097/01.MLG.0000170848.76045.47 NR 16 TC 12 Z9 13 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD OCT PY 2012 VL 121 IS 10 BP 635 EP 639 PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA 024LK UT WOS:000310110500002 PM 23130536 ER PT J AU Magliulo, G Gagliardi, S Appiani, MC Iannella, G Gagliardi, M AF Magliulo, Giuseppe Gagliardi, Silvia Appiani, Mario Ciniglio Iannella, Giannicola Gagliardi, Mario TI Selective Vestibular Neurolabyrinthitis of the Lateral and Superior Semicircular Canal Ampulla and Ampullary Nerves SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE cervical vestibular evoked myogenic potential; head impulse test; neurolabyrinthitis; ocular vestibular evoked myogenic potential ID EVOKED MYOGENIC POTENTIALS; NEURITIS AB Objectives: The diagnosis of vestibular neurolabyrinthitis is based on the sudden appearance of vertigo that lasts for hours or days without associated cochlear or central nervous system signs or symptoms. The advent of the video head impulse test, cervical vestibular evoked myogenic potential testing, and ocular vestibular evoked myogenic potential testing has provided interesting clinical evidence for evaluating and monitoring the damage to specific compartments of the vestibular apparatus. These various methods of testing individual end-organ functions may have a clinical impact on the vestibular workup of neurolabyrinthitis. Methods: This report describes 3 patients with acute vestibular neurolabyrinthitis in whom caloric tests, cervical vestibular evoked myogenic potentials, ocular vestibular evoked myogenic potentials, and the video head impulse test led to a suspicion of peripheral vestibular deficits of the lateral or superior semicircular canal ampulla or ampullary nerves. Results: In our patients, the examination results (normal hearing, absence of responses on caloric testing, and bilateral preservation of cervical and ocular vestibular evoked myogenic potentials) disclosed an acute partial superior vestibular neurolabyrinthitis. Conclusions: To our knowledge, these are the first reported cases in which selective damage to the lateral and superior semicircular canals and their nerves caused by neurolabyrinthitis was demonstrated clinically. Our clinical results indicate that the damage can be selective for specific vestibular end organs. C1 [Magliulo, Giuseppe; Gagliardi, Silvia; Appiani, Mario Ciniglio; Iannella, Giannicola; Gagliardi, Mario] Univ Roma La Sapienza, Dept Sensory Organs, Rome, Italy. RP Magliulo, G (reprint author), Via Gregorio 7,80, I-00165 Rome, Italy. CR Baloh RW, 2003, NEW ENGL J MED, V348, P1027, DOI 10.1056/NEJMcp021154 Curthoys IS, 2011, CLIN NEUROPHYSIOL, V122, P611, DOI 10.1016/j.clinph.2010.07.018 Curthoys IS, 2010, CLIN NEUROPHYSIOL, V121, P132, DOI 10.1016/j.clinph.2009.09.027 Govender S, 2011, CLIN NEUROPHYSIOL, V122, P1246, DOI 10.1016/j.clinph.2010.12.040 Kim JS, 2012, J NEUROL, V259, P1553, DOI 10.1007/s00415-011-6375-4 Magliulo G, 2004, ANN OTO RHINOL LARYN, V113, P1000 Murofushi T, 1996, ARCH OTOLARYNGOL, V122, P845 Schmid-Priscoveanu A, 2001, JARO, V2, P72, DOI 10.1007/s101620010060 Ulmer E, 2005, Ann Otolaryngol Chir Cervicofac, V122, P84, DOI 10.1016/S0003-438X(05)82329-1 NR 9 TC 4 Z9 4 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD OCT PY 2012 VL 121 IS 10 BP 640 EP 644 PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA 024LK UT WOS:000310110500003 PM 23130537 ER PT J AU Isaacson, G AF Isaacson, Glenn TI Tonsillectomy Healing SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE adenotonsillectomy; complication; inflammatory mediator; postoperative pain; tonsillectomy; wound healing ID CUTANEOUS WOUNDS; ORAL MUCOSAL; ELECTROCAUTERY; SCALPEL; MICRODEBRIDER; ANGIOGENESIS; HEMORRHAGE; EXPRESSION; MORBIDITY; LASER AB Objectives: We performed a prospective observation study in an outpatient surgical and office setting to compare human post-tonsillectomy healing to human cutaneous wound healing and to established animal models of oral healing. Methods: Fourteen teenaged patients underwent planned tonsillectomy. Intraoral digital photographs were collected at the time of tonsillectomy, during the management of complications, and at postoperative office visits. Serial intraoral photographs of one patient were taken at 48-hour intervals from the time of surgery until postoperative day 17. Results: Intraoral photographs from the days after tonsillectomy revealed a pattern of inflammation and healing that closely paralleled that in human skin and in canine and porcine oral wound models. Conclusions: Edema and pain are greatest immediately after surgery, probably as a result of thermal effects and expression of inflammatory mediators that stimulate pharyngeal nociceptors. Pain gradually decreases over time, with an increase in analog pain measures on postoperative days 3 to 5 corresponding to the maximal wound inflammation documented in experimental models. Epithelial ingrowth beneath a fibrin clot begins shortly after wounding. Separation of the fibrin clot about 7 days after surgery exposes vascular stroma. Involution of the vascular stroma and completion of epithelial coverage correlate with decreased pain levels and a lessened risk of bleeding. C1 [Isaacson, Glenn] Temple Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, Rydal, PA 19046 USA. [Isaacson, Glenn] Temple Univ, Sch Med, Dept Pediat, Rydal, PA 19046 USA. RP Isaacson, G (reprint author), Temple Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, 1077 Rydal Rd,Suite 201, Rydal, PA 19046 USA. CR Barnes HA, 1914, TONSILS FAUCIAL LING Broughton G, 2006, PLAST RECONSTR SURG, V117, p12S, DOI 10.1097/01.prs.0000225430.42531.c2 Bryant GL, 1998, LARYNGOSCOPE, V108, P13, DOI 10.1097/00005537-199801000-00003 Carew JF, 1998, LARYNGOSCOPE, V108, P373, DOI 10.1097/00005537-199803000-00012 Clark JD, 2007, MOL PAIN, V3, DOI 10.1186/1744-8069-3-28 Derkay CS, 2006, OTOLARYNG HEAD NECK, V134, P114, DOI 10.1016/j.otohns.2005.10.039 Falvo MR, 2010, BIOPHYS CHEM, V152, P15, DOI 10.1016/j.bpc.2010.08.009 Ghaffari A, 2006, J CELL BIOCHEM, V98, P383, DOI 10.1002/jcb.20782 Ilan N, 1998, J CELL SCI, V111, P3621 Isaacson G, 2005, ANN OTO RHINOL LARYN, V114, P757 Johnson K, 2008, OTOLARYNG HEAD NECK, V138, P486, DOI 10.1016/j.otohns.2007.11.016 Kumar VV, 2004, LARYNGOSCOPE, V114, P2031, DOI 10.1097/01.mlg.0000147942.82626.1c Liboon J, 1997, OTOLARYNG HEAD NECK, V116, P379, DOI 10.1016/S0194-5998(97)70277-8 Moir MS, 2000, LARYNGOSCOPE, V110, P1824, DOI 10.1097/00005537-200011000-00011 Nasr VG, 2008, PEDIATR ANESTH, V18, P673, DOI 10.1111/j.1460-9592.2008.02515.x Nathan C, 2002, NATURE, V420, P846, DOI 10.1038/nature01320 Riches DW, 1996, MOL CELLULAR BIOL WO, P95 Sarny S, 2011, LARYNGOSCOPE, V121, P2553, DOI 10.1002/lary.22347 Schrementi ME, 2008, WOUND REPAIR REGEN, V16, P80, DOI 10.1111/j.1524-475X.2007.00320.x Silveira H, 2003, INT J PEDIATR OTORHI, V67, P345, DOI 10.1016/S0165-5876(02)00399-3 Singer AJ, 1999, NEW ENGL J MED, V341, P738 Sinha UK, 2003, LARYNGOSCOPE, V113, P228, DOI 10.1097/00005537-200302000-00007 Statham MM, 2010, CURR OPIN OTOLARYNGO, V18, P539, DOI 10.1097/MOO.0b013e3283404dcc Szpaderska AM, 2003, J DENT RES, V82, P621 Szpaderska AM, 2005, J DENT RES, V84, P309 Thomson S, 1912, DIS NOSE THROAT, P369 Yener M, 2009, OTOLARYNG HEAD NECK, V140, P652, DOI 10.1016/j.otohns.2008.12.064 NR 27 TC 5 Z9 5 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD OCT PY 2012 VL 121 IS 10 BP 645 EP 649 PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA 024LK UT WOS:000310110500004 PM 23130538 ER PT J AU Kulekci, M Batioglu-Karaaltin, A Saatci, O Uzun, I AF Kulekci, Mehmet Batioglu-Karaaltin, Aysegul Saatci, Ozlem Uzun, Ibrahim TI Relationship Between the Branches of the Recurrent Laryngeal Nerve and the Inferior Thyroid Artery SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE anatomic relationship; branch; classification; inferior thyroid artery; recurrent laryngeal nerve ID ANATOMY; SURGERY AB Objectives: The relationship between the recurrent laryngeal nerve (RLN) and the inferior thyroid artery (ITA) is an important and helpful landmark for isolating the RLN and its branches during surgery. In the present study, we aimed to define and classify in detail all of the possible relationships between the two anatomic structures and their branches. Methods: We examined 100 specimens (200 sides) from cadavers of 76 men and 24 women who were between 16 and 90 years of age at the time of death. After anatomic dissection was performed, the relationship between the RLN and the ITA was noted for each side and documented in the form of high-resolution photographs. Results: The relationships of both structures and their branches were classified into 6 types. Details were verified regarding the relationships between the main trunks, between the trunks and branches, and between the branches, as follows: type A (ITA trunk to RLN trunk); type B (ITA branches to RLN trunk); type C (ITA trunk to RLN branches); type D (ITA branches to RLN trunk and RLN branches); type E (ITA branches to RLN branches); and type F (others). Conclusions: Despite the various anatomic and surgical studies already performed, in the present study we tried to demonstrate all types of relationships between the RLN and the ITA and their branches and devise a new, detailed classification of the possible relationships between the two structures. C1 [Batioglu-Karaaltin, Aysegul] Istanbul Educ & Res Hosp, Dept Otolaryngol Head & Neck Surg, TR-34098 Istanbul, Turkey. [Kulekci, Mehmet] Taksim Educ & Res Hosp, Dept Otolaryngol Head & Neck Surg, Istanbul, Turkey. [Saatci, Ozlem] Uskudar Govt Hosp, Dept Otolaryngol Head & Neck Surg, Istanbul, Turkey. [Uzun, Ibrahim] Mediterranean Univ, Sch Med, Dept Forens Med, Antalya, Turkey. RP Batioglu-Karaaltin, A (reprint author), Istanbul Educ & Res Hosp, Dept Otolaryngol Head & Neck Surg, TR-34098 Istanbul, Turkey. CR ALSALIHI AR, 1989, ACTA ANAT, V135, P245 Ardito G, 2004, AM J SURG, V187, P249, DOI 10.1016/j.amjsurg.2003.11.001 Aytac B, 2005, SAUDI MED J, V26, P1746 Beneragama T, 2006, ANZ J SURG, V76, P928, DOI 10.1111/j.1445-2197.2006.03899.x Bergamaschi R, 1998, AM J SURG, V176, P71, DOI 10.1016/S0002-9610(98)00099-3 Campos B A, 2000, Rev Hosp Clin Fac Med Sao Paulo, V55, P195 Dralle H, 2008, WORLD J SURG, V32, P1358 Freschi G, 1994, Minerva Chir, V49, P943 KATZ AD, 1993, AM SURGEON, V59, P188 Monfared A, 2002, LARYNGOSCOPE, V112, P386, DOI 10.1097/00005537-200202000-00033 Myssiorek D, 2004, OTOLARYNG CLIN N AM, V37, P25, DOI 10.1016/S0030-6665(03)00172-5 Reed AF, 1943, ANAT REC, V85, P17, DOI 10.1002/ar.1090850103 Schweizer V, 1997, CLIN OTOLARYNGOL, V22, P362, DOI 10.1046/j.1365-2273.1997.00028.x Shindo ML, 2005, OTOLARYNG HEAD NECK, V133, P514, DOI 10.1016/j.otohns.2005.07.010 Sun SQ, 2001, SURG RADIOL ANAT, V23, P363 Yalcin B, 2008, SURG RADIOL ANAT, V30, P215, DOI 10.1007/s00276-008-0318-5 Yalçin Bülent, 2007, ANZ J Surg, V77, P306, DOI 10.1111/j.1445-2197.2007.04044.x Yalcin B, 2008, SURGERY, V143, P453, DOI 10.1016/j.surg.2008.01.002 YILMAZ E, 1993, SURG RADIOL ANAT, V15, P197, DOI 10.1007/BF01627705 NR 19 TC 1 Z9 3 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD OCT PY 2012 VL 121 IS 10 BP 650 EP 656 PG 7 WC Otorhinolaryngology SC Otorhinolaryngology GA 024LK UT WOS:000310110500005 PM 23130539 ER PT J AU Coelho, DH Peng, A Thompson, M Sismanis, A AF Coelho, Daniel H. Peng, Angela Thompson, Meghan Sismanis, Aristides TI Cartilage Tympanoplasty in Smokers SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE cartilage; mastoidectomy; nicotine; smoking; tympanoplasty ID HEARING-LOSS; CIGARETTE-SMOKING; SHIELD TYMPANOPLASTY; SURGERY; CHILDREN; RISK; RECONSTRUCTION; PATHOLOGY; EXPOSURE; EFFUSION AB Objectives: We compared the outcomes of cartilage tympanoplasty in nonsmokers and smokers. Methods: We performed a retrospective chart review of patients who underwent cartilage tympanoplasty in a tertiary academic medical center from 1991 to 2010. There were 129 operations in 118 patients; 84 operations were performed in nonsmokers and 45 operations were performed in smokers. The primary outcome measure was the tympanic membrane graft take rate at the interval and most recent follow-up visits. Secondary measures included recurrence, the need for revision surgery, and hearing outcomes. Results: Nonsmokers and smokers had comparable long-term rates of intact eardrums (90.6% versus 92.9%; p = 0.99). There was a trend toward a higher rate of recurrent or persistent disease requiring further operation for smokers (13.3% versus 4.7%; p = 0.09). Both groups had improvement in pure tone averages (12.1 dB in nonsmokers and 12.8 dB in smokers) and air-bone gaps (9.6 dB in nonsmokers and 5.1 dB in smokers), although the rates were not statistically significantly different from each other. The rates of success of cartilage tympanoplasty in smokers appear superior to previously published rates of noncartilage tympanoplasty. Conclusions: Cartilage tympanoplasty has success rates and postoperative audiological measures that are comparable between smokers and nonsmokers. In smokers, cartilage grafting is superior to noncartilage grafting and is recommended for any patient who smokes and is undergoing tympanoplasty. C1 [Coelho, Daniel H.; Peng, Angela; Thompson, Meghan; Sismanis, Aristides] Virginia Commonwealth Univ, Dept Otolaryngol Head & Neck Surg, Richmond, VA 23298 USA. [Sismanis, Aristides] Univ Athens, Dept Otorhinolaryngol, Athens, Greece. RP Coelho, DH (reprint author), Virginia Commonwealth Univ, Dept Otolaryngol Head & Neck Surg, POB 980146, Richmond, VA 23298 USA. EM dcoelho@mcvh-vcu.edu CR AGIUS AM, 1995, ACTA OTO-LARYNGOL, V115, P44, DOI 10.3109/00016489509133345 Agrawal Y, 2009, OTOL NEUROTOL, V30, P139, DOI 10.1097/MAO.0b013e318192483c Aidonis I, 2005, OTOL NEUROTOL, V26, P838, DOI 10.1097/01.mao.0000185046.38900.1f Anderson J, 2004, OTOL NEUROTOL, V25, P856, DOI 10.1097/00129492-200411000-00002 [Anonymous], 1990, MMWR RECOMM REP, V39, P1 [Anonymous], 1990, MMWR RECOMM REP, V39, p[i, 1] [Anonymous], 1995, OTOLARYNGOL HEAD NEC, V113, P181 Becvarovski Z, 2001, LARYNGOSCOPE, V111, P1806, DOI 10.1097/00005537-200110000-00026 Briggs RD, 2004, LARYNGOSCOPE, V114, P126, DOI 10.1097/00005537-200401000-00022 CAMPBELL EE, 1990, AM J OTOL, V11, P66 Cantrell R W, 1970, Otolaryngol Clin North Am, V3, P141 Couloigner V, 2005, OTOL NEUROTOL, V26, P247, DOI 10.1097/00129492-200503000-00020 Cruickshanks KJ, 1998, JAMA-J AM MED ASSOC, V279, P1715, DOI 10.1001/jama.279.21.1715 Dornhoffer J, 2003, LARYNGOSCOPE, V113, P1844, DOI 10.1097/00005537-200311000-00002 Dornhoffer JL, 1997, LARYNGOSCOPE, V107, P1094, DOI 10.1097/00005537-199708000-00016 DUCKERT LG, 1995, AM J OTOL, V16, P21 ETZEL RA, 1992, PEDIATRICS, V90, P228 Ferrite S, 2005, OCCUP MED-OXFORD, V55, P48, DOI 10.1093/occmed/kqi002 Ferrucci L, 1998, JAMA-J AM MED ASSOC, V280, P963 Fukuchi Ilana, 2006, Braz J Otorhinolaryngol, V72, P267 FUREY SA, 1967, ANGIOLOGY, V18, P218, DOI 10.1177/000331976701800403 Garrett Bridgette E., 2011, Morbidity and Mortality Weekly Report, V60, P109 Gerber MJ, 2000, LARYNGOSCOPE, V110, P1994, DOI 10.1097/00005537-200012000-00002 Gierek Tatiana, 2004, Otolaryngol Pol, V58, P529 GLASSCOCK ME, 1982, LARYNGOSCOPE, V92, P718, DOI 10.1288/00005537-198207000-00002 Gopinath B, 2010, EAR HEARING, V31, P277, DOI 10.1097/AUD.0b013e3181c8e902 HALIK JJ, 1988, OTOLARYNG HEAD NECK, V98, P162 Hee J, 1985, Eur J Respir Dis Suppl, V139, P86 Kaylie DM, 2009, LARYNGOSCOPE, V119, P1384, DOI 10.1002/lary.20256 Krueger JK, 2001, PLAST RECONSTR SURG, V108, P1063, DOI 10.1097/00006534-200109150-00042 Kyrodimos E, 2007, OTOLARYNG HEAD NECK, V136, P982, DOI 10.1016/j.otohns.2006.12.025 Lee IW, 2006, OTOL NEUROTOL, V27, P433, DOI 10.1097/00129492-200604000-00023 Lin YC, 2011, ARCH OTOLARYNGOL, V137, P215, DOI 10.1001/archoto.2011.10 MILEWSKI C, 1993, LARYNGOSCOPE, V103, P1352 Molina Pichardo H, 2009, AN ORL MEX, V54, P45 Moore GF, 2002, LARYNGOSCOPE, V112, P1543, DOI 10.1097/00005537-200209000-00003 Nakanishi N, 2000, J OCCUP ENVIRON MED, V42, P1045, DOI 10.1097/00043764-200011000-00001 OHLIN P, 1976, PSYCHOPHARMACOLOGY, V49, P263, DOI 10.1007/BF00426827 Onal K, 2005, CLIN OTOLARYNGOL, V30, P115, DOI 10.1111/j.1365-2273.2004.00947.x SCHUKNECHT HF, 1985, LARYNGOSCOPE, V95, P249 SHELTON C, 1990, LARYNGOSCOPE, V100, P679 Smyth G D, 1970, Acta Otorhinolaryngol Belg, V24, P53 STEINBACH E, 1981, J LARYNGOL OTOL, V95, P1031, DOI 10.1017/S0022215100091787 Uguz MZ, 2008, EUR ARCH OTO-RHINO-L, V265, P513, DOI 10.1007/s00405-007-0485-8 Vastag E, 1985, Eur J Respir Dis Suppl, V139, P93 WULLSTEIN H, 1953, Monatsschr Ohrenheilkd Laryngorhinol, V87, P308 Yung M, 2008, J LARYNGOL OTOL, V122, P663, DOI 10.1017/S0022215108001813 ZOELLNER F, 1960, Triangle, V4, P126 NR 48 TC 0 Z9 1 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD OCT PY 2012 VL 121 IS 10 BP 657 EP 663 PG 7 WC Otorhinolaryngology SC Otorhinolaryngology GA 024LK UT WOS:000310110500006 PM 23130540 ER PT J AU Hutcheson, KA Jantharapattana, K Barringer, DA Lewin, JS Holsinger, FC AF Hutcheson, Katherine A. Jantharapattana, Kitti Barringer, Denise A. Lewin, Jan S. Holsinger, F. Christopher TI Functional and Oncological Outcomes of Primary Versus Salvage Transoral Laser Microsurgery for Supraglottic Carcinoma SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE supraglottic carcinoma; swallowing; transoral laser microsurgery ID CARBON-DIOXIDE LASER; SQUAMOUS-CELL CARCINOMA; LARYNGEAL-CANCER; NECK-CANCER; THERAPY; RESECTION; SURGERY; RADIOTHERAPY; IRRADIATION; TRIAL AB Objectives: We evaluated the functional and oncological outcomes of transoral laser microsurgery (TLM) in patients with previously untreated supraglottic carcinoma compared with the outcomes in salvage cases after radiation-based treatment. Methods: We conducted a retrospective case-control study at a single academic tertiary care institution. The functional outcomes were stratified by prior irradiation and were assessed at baseline, less than 1 week after operation, and at last follow-up. Results: Five patients underwent TLM for previously untreated disease, and 5 previously irradiated patients underwent salvage TLM for local failure. No patient required tracheostomy. There was no local recurrence after TLM as primary therapy, and none of those patients required radiotherapy. One salvage patient developed local recurrence. The duration of feeding tube dependence (p = 0.049) and the rates of chronic aspiration (more than 1 month after operation; p = 0.048) were significantly higher in the salvage TLM cases than in the previously untreated cases. The median scores on the PSS-HN Understandability of Speech were 75 ("usually understandable") in the salvage group and 100 ("always understandable") in the previously untreated group. Conclusions: Both local control and function were better in the previously untreated patients than in the salvage patients. Our findings provide support for the use of TLM as a primary treatment modality for selected supraglottic carcinomas, but also suggest a potential for functional recovery in both previously untreated and salvage cases. C1 [Hutcheson, Katherine A.; Jantharapattana, Kitti; Barringer, Denise A.; Lewin, Jan S.; Holsinger, F. Christopher] Univ Texas MD Anderson Canc Ctr, Dept Head & Neck Surg, Houston, TX 77230 USA. RP Holsinger, FC (reprint author), Univ Texas MD Anderson Canc Ctr, Dept Head & Neck Surg, Unit 441, Houston, TX 77230 USA. FU University of Texas; University of Texas School of Public Health-Cancer Prevention and Research Institute of Texas (CPRIT) [RP101503] FX From the Department of Head and Neck Surgery, The University of Texas M. D. Anderson Cancer Center, Houston, Texas. Drs Hutcheson and Jantharapattana contributed equally to this work. Dr Hutcheson acknowledges funding from The University of Texas Health Innovation for Cancer Prevention Research Fellowship, The University of Texas School of Public Health-Cancer Prevention and Research Institute of Texas (CPRIT) grant RP101503. The content is solely the responsibility of the authors and does not necessarily represent the official views of the CPRIT. CR Agrawal A, 2007, ARCH OTOLARYNGOL, V133, P1044, DOI 10.1001/archotol.133.10.1044 Ambrosch P, 1998, ANN OTO RHINOL LARYN, V107, P680 Carrara-de Angelis E, 2003, ARCH OTOLARYNGOL, V129, P733, DOI 10.1001/archotol.129.7.733 DESANTO LW, 1990, ANN OTO RHINOL LARYN, V99, P593 Eckel HE, 1997, OTOLARYNG HEAD NECK, V117, P681, DOI 10.1016/S0194-5998(97)70052-4 Grant DG, 2008, OTOLARYNG HEAD NECK, V138, P606, DOI 10.1016/j.otohns.2007.12.046 Grant DG, 2007, OTOLARYNG HEAD NECK, V136, P900, DOI 10.1016/j.otohns.2006.12.015 Greene FL, 2002, AJCC CANC STAGING HD, V6th Holsinger FC, 2008, CURR ONCOL REP, V10, P170, DOI 10.1007/s11912-008-0026-7 Hutcheson KA, 2008, ARCH OTOLARYNGOL, V134, P178, DOI 10.1001/archoto.2007.33 LEE NK, 1990, LARYNGOSCOPE, V100, P831 List MA, 1996, CANCER, V77, P2294, DOI 10.1002/(SICI)1097-0142(19960601)77:11<2294::AID-CNCR17>3.0.CO;2-S Logemann J, 1998, EVALUATION TREATMENT, V2nd LOGEMANN JA, 1994, J SPEECH HEAR RES, V37, P965 Machtay M, 2008, J CLIN ONCOL, V26, P3582, DOI 10.1200/JCO.2007.14.8841 MENDENHALL WM, 1990, HEAD NECK-J SCI SPEC, V12, P204, DOI 10.1002/hed.2880120303 Motamed M, 2006, LARYNGOSCOPE, V116, P451, DOI 10.1097/01.MLG.0000199591.92336.06 Motta G, 2004, HEAD NECK-J SCI SPEC, V26, P442, DOI 10.1002/hed.10395 Nguyen NP, 2007, ORL J OTO-RHINO-LARY, V69, P116, DOI 10.1159/000097843 Oeken J, 2001, EUR ARCH OTO-RHINO-L, V258, P250, DOI 10.1007/s004050100353 Roh IL, 2008, J SURG ONCOL, V98, P184, DOI 10.1002/jso.21101 Rudert HH, 1999, ANN OTO RHINOL LARYN, V108, P819 Schweinfurth JM, 2000, LARYNGOSCOPE, V110, P1266, DOI 10.1097/00005537-200008000-00008 SHIMM DS, 1989, AM J CLIN ONCOL-CANC, V12, P17, DOI 10.1097/00000421-198902000-00005 ZEITELS SM, 1994, LARYNGOSCOPE, V104, P71 NR 25 TC 1 Z9 1 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD OCT PY 2012 VL 121 IS 10 BP 664 EP 670 PG 7 WC Otorhinolaryngology SC Otorhinolaryngology GA 024LK UT WOS:000310110500008 PM 23130541 ER PT J AU Mahboubi, H Ziai, K Brunworth, J Djalilian, HR AF Mahboubi, Hossein Ziai, Kasra Brunworth, Joseph Djalilian, Hamid R. TI Accuracy of Tinnitus Pitch Matching Using a Web-Based Protocol SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE psychoacoustics; telemedicine; tinnitus AB Objectives: We investigated the accuracy of a web-based protocol for tinnitus frequency matching compared to that of tinnitus pitch matching performed by an audiologist using an audiometer in an anechoic chamber. Methods: Twenty subjects underwent tinnitus frequency-matching in a random order using an audiometer in an anechoic chamber and using web-based software with a multiple-choice protocol in octave or half-octave steps from 250 Hz to 12,000 Hz and a slider in 25-Hz steps from 20 to 20,000 Hz. Octave challenge testing was performed. The participants were asked to indicate which protocol resulted in the closest match to their tinnitus frequency. Results: The median tinnitus frequency was 6,000 Hz (range, 2,000 to 12,000 Hz) with use of the audiometer and self-directed multiple-choice protocol. With the slider, the median frequency was 5,925 Hz (range, 1,850 to 16,000 Hz). The patients with a tinnitus frequency higher than 12,000 Hz experienced a greater level of satisfaction when using the computer-based slider system. Five patients experienced octave confusion with self-directed multiple-choice tinnitus matching that was corrected accurately after the octave challenge step. Conclusions: A web-based protocol for tinnitus frequency matching is as accurate as a standard audiometric protocol. An octave challenge test might be necessary for patient-directed tinnitus frequency matching. C1 [Mahboubi, Hossein; Ziai, Kasra; Brunworth, Joseph; Djalilian, Hamid R.] Univ Calif Irvine, Dept Otolaryngol Head & Neck Surg, Div Neurotol & Skull Base Surg, Orange, CA 92868 USA. [Djalilian, Hamid R.] Univ Calif Irvine, Dept Biomed Engn, Orange, CA 92868 USA. RP Djalilian, HR (reprint author), Univ Calif Irvine, Dept Otolaryngol Head & Neck Surg, Div Neurotol & Skull Base Surg, 101 City Dr S,Bldg 56,Suite 500, Orange, CA 92868 USA. CR GRAHAM JT, 1962, ARCHIV OTOLARYNGOL, V75, P162 Henry JA, 2004, J REHABIL RES DEV, V41, P121, DOI 10.1682/JRRD.2004.02.0121 Henry JA, 2004, J REHABIL RES DEV, V41, P871, DOI 10.1682/JRRD.2003.10.0158 Henry JA, 2006, ACTA OTO-LARYNGOL, V126, P34, DOI 10.1080/03655230600895291 Henry J A, 2000, Am J Audiol, V9, P36, DOI 10.1044/1059-0889(2000/002) Moore BCJ, 2010, HEARING RES, V261, P51, DOI 10.1016/j.heares.2010.01.003 Okamoto H, 2010, P NATL ACAD SCI USA, V107, P1207, DOI 10.1073/pnas.0911268107 Pineda Jaime A, 2008, Int Tinnitus J, V14, P17 Tyler R, 2000, TINNITUS HDB, P149 Tyler R S, 1983, Br J Audiol, V17, P101, DOI 10.3109/03005368309078916 Vernon JA, 1980, AUDIOL HEAR ED, V6, P5 NR 11 TC 0 Z9 0 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD OCT PY 2012 VL 121 IS 10 BP 671 EP 674 PG 4 WC Otorhinolaryngology SC Otorhinolaryngology GA 024LK UT WOS:000310110500009 PM 23130542 ER PT J AU Ohki, M Ishikawa, J Kikuchi, S AF Ohki, Masafumi Ishikawa, Jyunichi Kikuchi, Shigeru TI Oral Frostbite Due to Dry Ice SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE dry ice; edema; frostbite; upper airway tract; volatile substance abuse ID INJURIES; ABUSE AB Objectives: Dry ice is a commercially available cryogen that is used worldwide. It may cause frostbite if misused. However, frostbite of the oral cavity due to dry ice has not been previously reported. Here, we describe the first case of dry ice induced frostbite of the oral cavity. Methods: We present a case of oral frostbite due to dry ice and subsequent swelling of the submandibular area and lower lip. We discuss the clinical features of oral frostbite clue to volatile substance abuse. Results: Oral frostbite not only may result in the impairment of the affected mucosae directly, but also may adversely affect the tissues in the vicinity of the oral cavity floor indirectly. Oral frostbite may cause edema of the upper airway tract. In case of severe pharyngolaryngeal edema, either tracheal intubation or tracheostomy is necessary. Steroids and antibiotics may be effective in preventing the development of pharyngolaryngeal edema. Conclusions: It is important to bear in mind that volatile substance abuse may possibly induce unusual events. In particular, special attention should be paid to delayed unusual events. C1 [Ohki, Masafumi; Ishikawa, Jyunichi; Kikuchi, Shigeru] Saitama Med Ctr, Dept Otolaryngol, Kawagoe, Saitama 3508550, Japan. RP Ohki, M (reprint author), Saitama Med Ctr, Dept Otolaryngol, 1981 Kamoda, Kawagoe, Saitama 3508550, Japan. CR Albright JT, 1999, INT J PEDIATR OTORHI, V49, P63 ELLIOTT DC, 1991, MIL MED, V156, P18 Golant A, 2008, J AM ACAD ORTHOP SUR, V16, P704 Koplewitz BZ, 2000, PEDIATRICS, V105, P121, DOI 10.1542/peds.105.1.121 KULKA JP, 1964, ANN NY ACAD SCI, V116, P1018, DOI 10.1111/j.1749-6632.1964.tb52565.x Kuspis DA, 1999, J TOXICOL-CLIN TOXIC, V37, P873 Long William B 3rd, 2005, J Long Term Eff Med Implants, V15, P67, DOI 10.1615/JLongTermEffMedImplants.v15.i1.80 Shirkey BL, 2007, J PEDIATR GASTR NUTR, V45, P361 Svartling N, 1996, ANAESTH INTENS CARE, V24, P717 VOGEL JE, 1989, CLIN PLAST SURG, V16, P565 Zook N, 1998, ANN PLAS SURG, V40, P246, DOI 10.1097/00000637-199803000-00009 NR 11 TC 0 Z9 0 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD OCT PY 2012 VL 121 IS 10 BP 675 EP 677 PG 3 WC Otorhinolaryngology SC Otorhinolaryngology GA 024LK UT WOS:000310110500010 PM 23130543 ER PT J AU Loh, WS Eu, DKC Loh, SRH Chao, SS AF Loh, Woei-Shyang Eu, Donovan K. C. Loh, Shaun R. H. Chao, Siew-Shuen TI Efficacy of Computed Tomographic Scans in the Evaluation of Patients With Esophageal Foreign Bodies SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE computed tomography; esophagoscopy; foreign body ID IMPACTED FISH BONES; MANAGEMENT; INGESTION; DIAGNOSIS AB Objectives: This study aimed to determine whether computed tomographic (CT) scans on which foreign body impaction cannot be detected can be relied upon to decide whether a patient requires further investigation by esophagoscopy. This information might minimize unnecessary esophagoscopy without incurring the risk of a missed impacted foreign body. Methods: In,a retrospective chart review of all patients admitted to National University Hospital, Singapore, over the period 2004 to 2011 for an ingested foreign body, case files of patients who underwent preoperative CT scanning followed by esophagoscopy were identified and reviewed. The results of the CT scan and the findings of esophagoscopy in these patients were analyzed. Results: A total of 376 patients underwent rigid esophagoscopy for an ingested foreign body during this period. Of these, 119 patients had CT scans performed before the endoscopy. Based on our analysis, the sensitivity of CT scanning was 100%, and the specificity was 70.6%. The positive predictive value was 89.5%, and the negative predictive value was 100%. None of the patients who had CT scans with no detectable foreign body had complications on follow-up. Conclusions: CT scanning appeared to be sensitive and specific in investigation of patients with an ingested foreign body. It also has a high negative predictive value, which may allow it to be the only preliminary investigation in these patients. Based on these data, a prospective study with close monitoring of patients who have CT scans with no detectable foreign body can be designed to accrue more patients to answer this query. C1 [Eu, Donovan K. C.; Loh, Shaun R. H.] Natl Univ Singapore Hosp, Dept Otolaryngol Head & Neck Surg, Singapore 119074, Singapore. [Loh, Woei-Shyang; Chao, Siew-Shuen] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Otolaryngol Head & Neck Surg, Singapore 117595, Singapore. RP Loh, WS (reprint author), Natl Univ Singapore Hosp, Dept Otolaryngol Head & Neck Surg, 5 Lower Kent Ridge Rd, Singapore 119074, Singapore. CR Akazawa Y, 2004, AURIS NASUS LARYNX, V31, P413, DOI 10.1016/j.anl.2004.09.007 DEROWE A, 1994, AM J OTOLARYNG, V15, P41, DOI 10.1016/0196-0709(94)90039-6 Eliashar R, 1999, ANN OTO RHINOL LARYN, V108, P708 Ell SR, 1996, J ROY SOC MED, V89, P31 EVANS RM, 1992, CLIN RADIOL, V46, P121, DOI 10.1016/S0009-9260(05)80316-2 Loh KS, 2000, OTOLARYNG HEAD NECK, V123, P613, DOI 10.1067/mhn.2000.110616 NANDI P, 1978, BRIT J SURG, V65, P5, DOI 10.1002/bjs.1800650103 NGAN JHK, 1990, ANN SURG, V211, P459, DOI 10.1097/00000658-199004000-00012 TONG MCF, 1995, J LARYNGOL OTOL, V109, P965 Watanabe K, 1998, J LARYNGOL OTOL, V112, P360 NR 10 TC 4 Z9 4 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD OCT PY 2012 VL 121 IS 10 BP 678 EP 681 PG 4 WC Otorhinolaryngology SC Otorhinolaryngology GA 024LK UT WOS:000310110500011 PM 23130544 ER PT J AU Balatsouras, DG Ganelis, P Aspris, A Economou, NC Moukos, A Koukoutsis, G AF Balatsouras, Dimitrios G. Ganelis, Panayotis Aspris, Andreas Economou, Nicolas C. Moukos, Antonis Koukoutsis, George TI Benign Paroxysmal Positional Vertigo Associated With Meniere's Disease: Epidemiological, Pathophysiologic, Clinical, and Therapeutic Aspects SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE benign paroxysmal positional vertigo; canalith repositioning procedure; hearing loss; Meniere's disease; nystagmography; vertigo ID REPOSITIONING MANEUVERS; SECONDARY; BPPV AB Objectives: We studied the demographic, pathogenetic, and clinical features of benign paroxysmal positional vertigo (BPPV) associated with Meniere's disease. Methods: The medical records of patients with BPPV associated with Meniere's disease were reviewed. In all patients, results of a complete otolaryngological, audiological, and neurotologic evaluation, including nystagmography, were available. Patients with idiopathic BPPV were used as a control group. Results: Twenty-nine patients with both disorders were found and were compared with 233 patients with idiopathic BPPV. The patients with BPPV associated with Meniere's disease presented the following features, in which they differed from the patients with idiopathic BPPV: 1) a higher percentage of female patients; 2) a longer duration of symptoms; 3) common involvement of the horizontal semicircular canal; 4) a greater incidence of canal paresis; and 5) more therapeutic sessions needed for cure and a higher rate of recurrence. Conclusions: The BPPV associated with Meniere's disease differs from idiopathic BPPV in regard to several epidemiological and clinical features, may follow a different course, and responds less effectively to treatment. C1 [Balatsouras, Dimitrios G.; Ganelis, Panayotis; Moukos, Antonis; Koukoutsis, George] Tzan Gen Hosp, Dept Otolaryngol, Piraeus, Greece. [Economou, Nicolas C.] Gen Hosp Asklepieio, Dept Otolaryngol, Voula, Greece. [Aspris, Andreas] Nicosia Gen Hosp, Dept Otolaryngol, Nicosia, Cyprus. RP Balatsouras, DG (reprint author), 23 Achaion Str, Athens 15343, Greece. CR American Academy of Otolaryngology-Head and Neck Foundation, 1995, OTOLARYNGOL HEAD NEC, V113, P181, DOI DOI 10.1016/S0194-5998(95)70102-8 Balatsouras DG, 2011, INT J OTOLARYNGOL, V2011 BALOH RW, 1987, NEUROLOGY, V37, P371 Bhattacharyya N, 2008, OTOLARYNG HEAD NECK, V139, pS47, DOI 10.1016/j.otohns.2008.08.022 Buckingham RA, 1999, LARYNGOSCOPE, V109, P717, DOI 10.1097/00005537-199905000-00008 Caldas Mariana Azevedo, 2009, Braz J Otorhinolaryngol, V75, P502, DOI 10.1590/S1808-86942009000400006 DelaMeilleure G, 1996, J NEUROL NEUROSUR PS, V60, P68, DOI 10.1136/jnnp.60.1.68 Del Rio M, 2004, OTOLARYNG HEAD NECK, V130, P426, DOI 10.1016/j.otohns.2003.12.015 Dornhoffer JL, 2000, AM J OTOL, V21, P230 Ganança Cristina Freitas, 2007, Braz J Otorhinolaryngol, V73, P506 Gross EM, 2000, LARYNGOSCOPE, V110, P655, DOI 10.1097/00005537-200004000-00022 Hughes CA, 1997, LARYNGOSCOPE, V107, P607, DOI 10.1097/00005537-199705000-00010 Karlberg M, 2000, ACTA OTO-LARYNGOL, V120, P380 KATSARKAS A, 1978, J OTOLARYNGOL, V7, P320 Korres S, 2006, J LARYNGOL OTOL, V120, P528, DOI 10.1017/S0022215106000958 Korres S, 2002, OTOL NEUROTOL, V23, P926, DOI 10.1097/00129492-200211000-00019 Korres S, 2011, OTOL NEUROTOL, V32, P1302, DOI 10.1097/MAO.0b013e31822f0bc5 Korres S, 2008, INT J AUDIOL, V47, P276, DOI 10.1080/14992020801958843 Korres SG, 2004, ANN OTO RHINOL LARYN, V113, P313 Korres SG, 2004, OTOLARYNG HEAD NECK, V131, P438, DOI 10.1016/j.otohns.2004.02.046 Lee NH, 2010, OTOLARYNG HEAD NECK, V143, P413, DOI 10.1016/j.otohns.2010.06.905 Li P, 2010, SCI RES ESSAYS, V5, P3672 Manzari L, 2008, MED HYPOTHESES, V70, P61, DOI 10.1016/j.mehy.2007.04.032 Morita N, 2009, OTOL NEUROTOL, V30, P956, DOI 10.1097/MAO.0b013e3181b24368 Paparella MM, 2008, ENT-EAR NOSE THROAT, V87, P562 Parnes LS, 2003, CAN MED ASSOC J, V169, P681 Riga M, 2011, INT J OTOLARYNGOL, V2011 Sajjadi H, 2008, LANCET, V372, P406, DOI 10.1016/S0140-6736(08)61161-7 Tanimoto H, 2008, J OTOLARYNGOL-HEAD N, V37, P832, DOI 10.2310/7070.2008.OA0188 Uno A, 2001, Nihon Jibiinkoka Gakkai Kaiho, V104, P9 NR 30 TC 4 Z9 4 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD OCT PY 2012 VL 121 IS 10 BP 682 EP 688 PG 7 WC Otorhinolaryngology SC Otorhinolaryngology GA 024LK UT WOS:000310110500012 PM 23130545 ER PT J AU Xu, W Han, DM Hu, R Bai, Y Zhang, L AF Xu, Wen Han, Demin Hu, Rong Bai, Yu Zhang, Li TI Characteristics of Vocal Fold Immobility Following Endotracheal Intubation SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article; Proceedings Paper CT 40th Annual Voice-Foundation Symposium on Care of the Professional Voice CY JUN 04-05, 2011 CL Philadelphia, PA SP Voice Fdn DE arytenoid dislocation; closed reduction; general anesthesia; intubation; laryngeal electromyography; vocal fold immobility ID ARYTENOID DISLOCATION; LARYNGEAL ELECTROMYOGRAPHY; SUBLUXATION; DIAGNOSIS AB Objectives: We investigated the clinical and laryngeal electromyography (LEMG) characteristics and the outcome of closed reduction of arytenoid cartilage dislocation in patients with vocal fold immobility (VFI) following endotracheal intubation. Methods: Sixty patients with VFI following endotracheal intubation were included. Closed reduction was performed under local anesthesia in 54 cases. Another 6 patients did not undergo an intervention. Laryngeal behaviors and voice function were evaluated. Forty-five patients underwent LEMG testing. Results: All patients complained of persistent hoarseness immediately following surgery. The LEMG results for 29 of 45 patients showed normal patterns (15 cases) or mildly abnormal patterns (14 cases) on the affected side. Sixteen cases displayed apparent abnormal LEMG patterns on the affected side. The voices of all 54 patients improved after reduction. The movement of the affected vocal folds recovered to normal in 51 cases. One month after reduction, neuromuscular function had improved in 29 of 30 cases. Among the 6 patients who did not undergo intervention, 3 had normal or slightly hoarse voices, and 3 experienced moderate hoarseness. Conclusions: Vocal fold immobility following endotracheal intubation is typically caused by arytenoid dislocation. Some instances were accompanied by an abnormality of the recurrent laryngeal nerve. A timely closed arytenoid reduction should be performed to restore patients' normal voices and vocal fold mobility. Our reduction technique under local anesthesia can be performed easily and obtains satisfactory outcomes within 6 weeks after endotracheal intubation. C1 [Xu, Wen; Han, Demin; Hu, Rong; Bai, Yu; Zhang, Li] Capital Med Univ, Beijing Tongren Hosp, Dept Otorhinolaryngol Head & Neck Surg, Beijing 100730, Peoples R China. RP Han, DM (reprint author), Capital Med Univ, Beijing Tongren Hosp, Dept Otorhinolaryngol Head & Neck Surg, 1 Dongjiao Minxiang, Beijing 100730, Peoples R China. CR CAVO JW, 1985, LARYNGOSCOPE, V95, P1352 CLOSE LG, 1987, HEAD NECK-J SCI SPEC, V9, P341, DOI 10.1002/hed.2890090607 KAMBIC V, 1978, BRIT J ANAESTH, V50, P587, DOI 10.1093/bja/50.6.587 Norris BK, 2011, LARYNGOSCOPE, V121, P142, DOI 10.1002/lary.21276 Paulsen FP, 1999, ANESTHESIOLOGY, V91, P659, DOI 10.1097/00000542-199909000-00016 PEPPARD SB, 1983, ANN OTO RHINOL LARYN, V92, P327 Rontal E, 1998, J VOICE, V12, P383, DOI 10.1016/S0892-1997(98)80029-5 Rubin AD, 2005, J VOICE, V19, P687, DOI 10.1016/j.jvoice.2004.11.002 Sataloff RT, 1998, OPER TECH OTOLARYNGO, V9, P196, DOI 10.1016/S1043-1810(98)80004-3 SATALOFF RT, 1994, LARYNGOSCOPE, V104, P1353 Tucker HM, 1987, LARYNX, V203, P348 Xu W, 2007, ANN OTO RHINOL LARYN, V116, P576 Xu W, 2009, ANN OTO RHINOL LARYN, V118, P656 Yin SGS, 1997, LARYNGOSCOPE, V107, P126, DOI 10.1097/00005537-199701000-00024 NR 14 TC 2 Z9 3 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD OCT PY 2012 VL 121 IS 10 BP 689 EP 694 PG 6 WC Otorhinolaryngology SC Otorhinolaryngology GA 024LK UT WOS:000310110500013 PM 23130546 ER PT J AU Bjorck, G Margolin, G Maback, G Persson, JKE Mattsson, P Hydman, J AF Bjorck, Gunnar Margolin, Gregory Maback, Gudrun Persson, Jonas K. E. Mattsson, Per Hydman, Jonas TI New Animal Model for Assessment of Functional Laryngeal Motor Innervation SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE electrophysiology; innervation; larynx; recurrent laryngeal nerve; superior laryngeal nerve ID POSTERIOR CRICOARYTENOID MUSCLE; FIBER TYPES; NERVE; REINNERVATION; PATTERNS; BRANCH; VARIABILITY; DENERVATION; HUMANS AB Objectives: The functional motor innervation of the larynx is not fully understood because of the complexity of the peripheral neuroanatomy. Since the late 19th century, there has been controversy regarding the role of the superior laryngeal nerve, which may have wider motor projections than are currently acknowledged. The aim of this study was to develop a large animal model to characterize and quantify the functional motor input to the intrinsic laryngeal muscles. Methods: We performed invasive electrophysiology (evoked electromyography) in normal pigs. Results: The thyroarytenoid, lateral cricoarytenoid, and posterior cricoarytenoid muscles receive dual innervation from both the superior and recurrent laryngeal nerves, whereas the cricothyroid muscle is innervated only by the superior laryngeal nerve. Conclusions: The dual innervation pattern from both laryngeal nerves supports the concept of a laryngeal nerve plexus. The motor input through the external branch of the superior laryngeal nerve was surprisingly high. The animal model presented here may be used in future investigations of laryngeal reinnervation following nerve injury. C1 [Hydman, Jonas] Karolinska Univ Hosp, Karolinska Inst, Dept Clin Neurosci, Neurosurg Res Lab, SE-17176 Stockholm, Sweden. [Bjorck, Gunnar; Margolin, Gregory; Hydman, Jonas] Karolinska Univ Hosp, Dept Otorhinolaryngol, SE-17176 Stockholm, Sweden. [Maback, Gudrun; Persson, Jonas K. E.] Karolinska Univ Hosp, Dept Clin Neurophysiol, SE-17176 Stockholm, Sweden. RP Hydman, J (reprint author), Karolinska Univ Hosp, Karolinska Inst, Dept Clin Neurosci, Neurosurg Res Lab, R2 02, SE-17176 Stockholm, Sweden. FU Swedish National Board of Health and Welfare; Foundation of Lars Hiertas Minne FX From the Departments of Otorhinolaryngology (Bjorck, Margolin, Hydman) and Clinical Neurophysiology (Maback, Persson), Karolinska University Hospital, and the Department of Clinical Neuroscience, Karolinska Institutet (Mattsson, Hydman), Stockholm, Sweden. Supported by grants from the Swedish National Board of Health and Welfare and the Foundation of Lars Hiertas Minne. CR Dilworth TFM, 1921, J ANAT, V56, P48 Exner, SITZ KAIS AK WISS 18 Hoh JFY, 2005, ACTA PHYSIOL SCAND, V183, P133, DOI 10.1111/j.1365-201X.2004.01402.x Hydman J, 2008, MUSCLE NERVE, V38, P1280, DOI 10.1002/mus.21124 Kimura J, 2001, ELECTRODIAGNOSIS DIS Kingham PJ, 2005, MUSCLE NERVE, V32, P761, DOI 10.1002/mus.20409 Knight M, 2002, J Anat, V201, P425 Knight MJ, 2005, EUR ARCH OTO-RHINO-L, V262, P281, DOI 10.1007/s00405-004-0803-3 LUDLOW CL, 1992, ANN OTO RHINOL LARYN, V101, P127 Maranillo E, 2003, LARYNGOSCOPE, V113, P525, DOI 10.1097/00005537-200303000-00024 Maranillo E, 2003, LARYNGOSCOPE, V113, P602, DOI 10.1097/00005537-200304000-00004 Maranillo E, 2005, LARYNGOSCOPE, V115, P358, DOI 10.1097/01.mlg.0000154745.78808.02 Martin-Oviedo C, 2011, LARYNGOSCOPE, V121, P2338, DOI 10.1002/lary.22340 Mathieson LC, 2008, SCOTT BROWNS OTORHIN, P2155 Mu LC, 2009, J VOICE, V23, P21, DOI 10.1016/j.jvoice.2007.08.001 Nasri S, 1997, ANN OTO RHINOL LARYN, V106, P594 Rhee HS, 2004, J HISTOCHEM CYTOCHEM, V52, P581 Rosenbach O, 1880, BRESL ARZTL Z, P14 SANDERS I, 1993, ARCH OTOLARYNGOL, V119, P934 SANDERS I, 1995, ARCH OTOLARYNGOL, V121, P754 WU BL, 1994, ARCH OTOLARYNGOL, V120, P1321 Sanudo JR, 1999, LARYNGOSCOPE, V109, P983 Semon F, 1881, ARCH LARYNGOL, P197 Shiotani A, 1998, LARYNGOSCOPE, V108, P1225, DOI 10.1097/00005537-199808000-00023 Sobotta J, 2001, ATLAS HUMAN ANATOMY Stavroulaki P, 2001, J LARYNGOL OTOL, V115, P257 Tucker HM, 1993, LARYNX Woo JS, 2008, ANN OTO RHINOL LARYN, V117, P749 WUSTROW TPU, 1988, LARYNGO RHINO OTOL, V67, P275, DOI 10.1055/s-2007-998497 NR 29 TC 3 Z9 3 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD OCT PY 2012 VL 121 IS 10 BP 695 EP 699 PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA 024LK UT WOS:000310110500014 PM 23130547 ER PT J AU Sarin, J Grenman, R Aitasalo, K Pulkkinen, J AF Sarin, Jussi Grenman, Reidar Aitasalo, Kalle Pulkkinen, Jaakko TI Bioactive Glass S53P4 in Mastoid Obliteration Surgery for Chronic Otitis Media and Cerebrospinal Fluid Leakage SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE bioactive glass; cerebrospinal fluid; cholesteatoma; chronic otitis media; mastoid obliteration ID CANAL WALL RECONSTRUCTION; REVISION MASTOIDECTOMY; HYDROXYAPATITE CEMENT; CAVITY OBLITERATION; TISSUE; FLAP; TYMPANOMASTOIDECTOMY; MICROORGANISMS; EXPERIENCE; BACTERIA AB Objectives: We evaluated the results of cases of chronic otitis media treated with mastoid obliteration surgery using bioactive glass S53P4. Methods: Twenty-five patients with chronic otitis media and 1 patient with cerebrospinal fluid leakage without chronic infection were treated with bioactive glass S53P4. Twenty patients had had previous surgery because of chronic otitis media with or without cholesteatoma. A mastoid obliteration was performed with bioactive glass S53P4 granules and a musculoperiosteal flap with or without bone pate. In 2 patients with a bony dehiscence at the middle cranial fossa, a bioactive glass plate was used to support the protruding dura. In addition, in 3 patients, occlusion of a dural fistula was needed The median follow-up period was 34.5 months (range, 1 to 182 months). Results: Excluding the 2 patients with only 1 month of follow-up at our department, 96% of the patients had a dry, safe ear or only intermittent otorrhea. In 92% of the patients, the objective of achieving a smaller or nonexistent cavity was achieved. Conclusions: Bioactive glass S53P4 is a noteworthy material in mastoid obliteration surgery. C1 [Sarin, Jussi; Grenman, Reidar; Aitasalo, Kalle; Pulkkinen, Jaakko] Univ Turku, Turku 20521, Finland. [Sarin, Jussi; Grenman, Reidar; Aitasalo, Kalle; Pulkkinen, Jaakko] Turku Univ Hosp, Dept Otorhinolaryngol Head & Neck Surg, Turku 20521, Finland. RP Pulkkinen, J (reprint author), Univ Turku, POB 52, Turku 20521, Finland. CR Abdel-Rahman Akram M, 2008, BMC Ear Nose Throat Disord, V8, P4, DOI 10.1186/1472-6815-8-4 Aitasalo KMJ, 2007, PLAST RECONSTR SURG, V120, P1963, DOI 10.1097/01.prs.0000287319.34425.27 Bennett M, 2006, OTOLARYNG CLIN N AM, V39, P1095, DOI 10.1016/j.otc.2006.08.012 Bizakis JG, 2006, J OTOLARYNGOL, V35, P48, DOI 10.2310/7070.2005.4120 Della Santina CC, 2006, ARCH OTOLARYNGOL, V132, P617, DOI 10.1001/archotol.132.6.617 Dornhoffer JL, 2008, LARYNGOSCOPE, V118, P1427, DOI [10.1097/MLG.0b013e318173dd7e, 10.1097/MLG.0b013e31817dd7e] Dornhoffer JL, 1999, OTOLARYNG HEAD NECK, V120, P361, DOI 10.1016/S0194-5998(99)70276-7 Gantz BJ, 2005, LARYNGOSCOPE, V115, P1734, DOI 10.1097/01.MLG.0000187572.99335.cc IRVING RM, 1994, CLIN OTOLARYNGOL, V19, P158, DOI 10.1111/j.1365-2273.1994.tb01202.x Jang CH, 2002, CLIN OTOLARYNGOL, V27, P509, DOI 10.1046/j.1365-2273.2002.00617.x Jang CH, 2007, IN VIVO, V21, P651 Kos MI, 2004, ANN OTO RHINOL LARYN, V113, P872 Leatherman BD, 2004, OTOL NEUROTOL, V25, P22, DOI 10.1097/00129492-200401000-00005 Lee WS, 2005, OTOL NEUROTOL, V26, P1107, DOI 10.1097/01.mao.0000184603.32796.6c Lee WS, 2009, ACTA OTO-LARYNGOL, V129, P955, DOI 10.1080/00016480802510178 Lepparanta O, 2008, J MATER SCI-MATER M, V19, P547, DOI 10.1007/s10856-007-3018-5 Lindfors NC, 2010, BONE, V47, P212, DOI 10.1016/j.bone.2010.05.030 Linthicum FH, 2002, LARYNGOSCOPE, V112, P1777, DOI 10.1097/00005537-200210000-00013 Mahendran S, 2004, OTOL NEUROTOL, V25, P19, DOI 10.1097/00129492-200401000-00004 Mehta RP, 2006, OTOLARYNG CLIN N AM, V39, P1129, DOI 10.1016/j.otc.2006.08.007 Mokbel KM, 2011, EUR ARCH OTORHINOLAR Mudry A, 2009, J LARYNGOL OTOL, V123, P583, DOI 10.1017/S0022215109004484 Munukka E, 2008, J MATER SCI-MATER M, V19, P27, DOI 10.1007/s10856-007-3143-1 Nadol JB, 2006, OTOLARYNG CLIN N AM, V39, P723, DOI 10.1016/j.ote.2006.05.003 PALVA T, 1973, ACTA OTO-LARYNGOL, V75, P289, DOI 10.3109/00016487309139718 Peltola M, 2008, J ORAL MAXIL SURG, V66, P639, DOI 10.1016/j.joms.2007.11.019 Peltola MJ, 2008, J ORAL MAXIL SURG, V66, P1699, DOI 10.1016/j.joms.2007.11.020 Rahaman MN, 2011, ACTA BIOMATER, V7, P2355, DOI 10.1016/j.actbio.2011.03.016 Ramsey MJ, 2004, OTOL NEUROTOL, V25, P873, DOI 10.1097/00129492-200411000-00004 Ridenour JS, 2008, OTOLARYNG HEAD NECK, V139, P641, DOI 10.1016/j.otohns.2008.07.020 Singh V, 2007, OTOLARYNG HEAD NECK, V137, P433, DOI 10.1016/j.otohns.2007.02.034 Stoor P, 2010, ANN OTO RHINOL LARYN, V119, P377 Stoor P, 1998, ACTA ODONTOL SCAND, V56, P161 Stoor P, 1999, J BIOMED MATER RES, V48, P869, DOI 10.1002/(SICI)1097-4636(1999)48:6<869::AID-JBM16>3.0.CO;2-6 Stoor P, 2001, J BIOMED MATER RES, V58, P113, DOI 10.1002/1097-4636(2001)58:1<113::AID-JBM170>3.0.CO;2-V Stow NW, 2010, OTOL NEUROTOL, V31, P964, DOI 10.1097/MAO.0b013e3181e3d33c WILSON J, 1981, J BIOMED MATER RES, V15, P805, DOI 10.1002/jbm.820150605 Zhang D, 2010, J BIOMED MATER RES A, V93A, P475, DOI 10.1002/jbm.a.32564 NR 38 TC 6 Z9 6 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD SEP PY 2012 VL 121 IS 9 BP 563 EP 569 PG 7 WC Otorhinolaryngology SC Otorhinolaryngology GA 006WZ UT WOS:000308851800001 PM 23012893 ER PT J AU Laccourreye, O Malinvaud, D Holsinger, FC Consoli, S Menard, M Bonfils, P AF Laccourreye, Ollivier Malinvaud, David Holsinger, F. Christopher Consoli, Silla Menard, Madeleine Bonfils, Pierre TI Trade-Off Between Survival and Laryngeal Preservation in Advanced Laryngeal Cancer: The Otorhinolaryngology Patient's Perspective SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE laryngeal cancer; organ preservation; patient's opinion; trade-off ID CELL LUNG-CANCER; TREATMENT DECISIONS; TREATMENT CHOICES; PROSTATE-CANCER; TIME TRADEOFF; PREFERENCES; QUALITY; LIFE; CHEMOTHERAPY; ATTITUDES AB Objectives: We performed a prospective study to evaluate, from the patient's perspective, the trade-off between speech and survival that individuals face when given a diagnosis of advanced-stage laryngeal cancer amenable to either total laryngectomy or a laryngeal preservation protocol using chemotherapy and radiotherapy. Methods: Volunteers (309) consecutively seen at the otorhinolaryngology clinic of a university teaching hospital in France completed an anonymous questionnaire designed to determine their position if they faced the diagnosis of an advanced-stage laryngeal cancer. Univariate analysis was performed for potential statistical relationships with various variables. Results: We found that 12.9% of patients were unable to determine their position regarding the two treatment options offered, and this group had a significant statistical relationship with four variables (age, education, professional status, and history of cancer among relatives). We found that 24.6% of patients made survival their main consideration and would not consider any trade-off. Among the 62.5% who considered the trade-off, the percentage of cure that patients were ready to lose in order to preserve their larynx varied from 5% to 100% (mean, 33%; SD, 23%). Aside from the undecided group, none of the variables analyzed was related either to the decision as to whether to consider a trade-off or to the percentage of cure that patients agreed to trade to preserve their larynx. Conclusions: In patients with advanced-stage laryngeal cancer, treatment should be initiated only after careful evaluation of the patient's attitude toward both laryngeal preservation and survival. C1 [Laccourreye, Ollivier; Malinvaud, David; Holsinger, F. Christopher; Menard, Madeleine; Bonfils, Pierre] Univ Paris Descartes Sorbonne Paris Cite, HEGP, AP HP,Dept Otorhinolaryngol Head & Neck Surg, Serv Otorhinolaryngol & Chirurg Cerv Faciale, F-75015 Paris, France. [Consoli, Silla] Univ Paris Descartes Sorbonne Paris Cite, HEGP, AP HP, Dept Psychiat, F-75015 Paris, France. [Holsinger, F. Christopher] Univ Texas MD Anderson Canc Ctr, Dept Surg, Houston, TX 77030 USA. RP Laccourreye, O (reprint author), Univ Paris Descartes Sorbonne Paris Cite, HEGP, AP HP,Dept Otorhinolaryngol Head & Neck Surg, Serv Otorhinolaryngol & Chirurg Cerv Faciale, 20-40 Rue Leblanc, F-75015 Paris, France. RI Consoli, Silla/C-8278-2013 FU Progres FX From the Departments of Otorhinolaryngology Head and Neck Surgery (Laccourreye, Malinvaud, Holsinger, Manard, Bonfils) and Psychiatry (Consoli), Universite Paris Descartes Sorbonne Paris Cite, APHP, HEGP, Paris, France, and the Department of Surgery, University of Texas M. D. Anderson Cancer Center, Houston, Texas (Holsinger). Supported in part by Progres 2000. CR Basu A, 2010, MED DECIS MAKING, V30, P355, DOI 10.1177/0272989X09349959 Bruera E, 2002, CANCER, V94, P2076, DOI 10.1002/cncr.10393 Brundage MD, 1997, J CLIN ONCOL, V15, P330 Brundage MD, 2001, PATIENT EDUC COUNS, V45, P149, DOI 10.1016/S0738-3991(01)00155-0 Chen AY, 2007, ARCH OTOLARYNGOL, V133, P1270, DOI 10.1001/archotol.133.12.1270 Cheung SW, 2010, OTOL NEUROTOL, V31, P284, DOI 10.1097/MAO.0b013e3181cc06cb Forastiere AA, 2003, NEW ENGL J MED, V349, P2091, DOI 10.1056/NEJMoa031317 Forastiere AA, 2006, J CLIN ONCOL, V24, P5517 Hankins J, 2007, PEDIATR BLOOD CANCER, V48, P705, DOI 10.1002/pbc.20903 Hoffman HT, 2006, LARYNGOSCOPE, V116, P1, DOI 10.1097/01.mlg.0000236095.97947.26 Holsinger FC, 2008, CURR ONCOL REP, V10, P170, DOI 10.1007/s11912-008-0026-7 Jansen SJT, 1998, MED DECIS MAKING, V18, P391, DOI 10.1177/0272989X9801800406 MCNEIL BJ, 1981, NEW ENGL J MED, V305, P982, DOI 10.1056/NEJM198110223051704 Pfister DG, 2006, J CLIN ONCOL, V24, P3693, DOI 10.1200/JCD.2006.07.4559 Solomon MJ, 2003, DIS COLON RECTUM, V46, P1351, DOI 10.1097/01.DCR.0000084432.45536.83 Sommers BD, 2008, CANCER, V113, P2058, DOI 10.1002/cncr.23807 Stiggelbout AM, 1996, MED DECIS MAKING, V16, P184, DOI 10.1177/0272989X9601600211 WOLF GT, 1991, NEW ENGL J MED, V324, P1685 Unic I, 2000, MED DECIS MAKING, V20, P251, DOI 10.1177/0272989X0002000301 Zolciak A, 2006, COLORECTAL DIS, V8, P575, DOI 10.1111/j.1463-1318.2006.01000.x NR 20 TC 7 Z9 7 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD SEP PY 2012 VL 121 IS 9 BP 570 EP 575 PG 6 WC Otorhinolaryngology SC Otorhinolaryngology GA 006WZ UT WOS:000308851800002 PM 23012894 ER PT J AU Leong, SC Wilkie, MD Webb, CJ AF Leong, Samuel C. Wilkie, Mark D. Webb, Christopher J. TI Impact of Endoscopic Stapling of Zenker's Diverticulum on Patient Health Status as Assessed by the Glasgow Benefit Inventory SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE delivery of health care; endoscopy; quality of life; Zenker's diverticulum ID PHARYNGEAL POUCH SURGERY AB Objectives: The aim of this study was to measure the effect of endoscopic stapling of Zenker's diverticulum on the health status of patients. Methods: We used the Glasgow Benefit Inventory (GBI) tool to ascertain patients' perceived experience. Results: The study demonstrated a positive health impact following endoscopic stapling of the Zenker's diverticulum. The mean total GBI score was +18.9 (95% confidence interval, +/- 11.2). The impact of endoscopic stapling was positive for all three subsets of the GBI. The GBI scores were comparable to those obtained after other common otorhinolaryngo-logical procedures such as tonsillectomy, rhinoplasty, and middle ear surgery. Conclusions: These data should improve our ability to counsel patients regarding important therapeutic decisions and expectations of surgical outcome. C1 [Leong, Samuel C.; Wilkie, Mark D.; Webb, Christopher J.] Royal Liverpool Univ Hosp, Dept Otorhinolaryngol Head & Neck Surg, Liverpool L7 8XP, Merseyside, England. RP Leong, SC (reprint author), Royal Liverpool Univ Hosp, Dept Otorhinolaryngol Head & Neck Surg, Prescot St, Liverpool L7 8XP, Merseyside, England. CR Calder NJ, 2007, J LARYNGOL OTOL, V121, P1060, DOI 10.1017/S0022215107006500 Chang CY, 2003, LARYNGOSCOPE, V113, P957, DOI 10.1097/00005537-200306000-00009 Draper MR, 2007, J OTOLARYNGOL, V36, P13, DOI 10.2310/7070.2006.0050 Ong CC, 1999, J LARYNGOL OTOL, V113, P233 Robinson K, 1996, ANN OTO RHINOL LARYN, V105, P415 Schwentner I, 2007, SWISS MED WKLY, V137, P454 Sen P, 2004, J LARYNGOL OTOL, V118, P601 Siddiq MA, 2004, ANN ROY COLL SURG, V86, P247, DOI 10.1308/147870804524 Spielmann PM, 2009, RHINOLOGY, V47, P48 Weller MD, 2004, EUR ARCH OTO-RHINO-L, V261, P331, DOI 10.1007/s00405-003-0689-5 NR 10 TC 1 Z9 1 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD SEP PY 2012 VL 121 IS 9 BP 576 EP 578 PG 3 WC Otorhinolaryngology SC Otorhinolaryngology GA 006WZ UT WOS:000308851800003 PM 23012895 ER PT J AU Steinke, JW Payne, SC Chen, PG Negri, J Stelow, EB Borish, L AF Steinke, John W. Payne, Spencer C. Chen, Philip G. Negri, Julie Stelow, Edward B. Borish, Larry TI Etiology of Nasal Polyps in Cystic Fibrosis: Not a Unimodal Disease SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE cystic fibrosis; DNA; eosinophil; histology; mucolytic; nasal polyp; neutrophil ID CHRONIC HYPERPLASTIC SINUSITIS; DORNASE-ALPHA; CHRONIC RHINOSINUSITIS; EOSINOPHILIA; EXPRESSION; CELLS; IL-5 AB Objectives: The objective was to determine whether the polyp subtypes observed in cystic fibrosis (CF)-related sinusitis were similar to those observed in non-CF-related sinusitis. Methods: Polyp and mucus samples were collected from CF patients who presented for sinus surgery. The polyps underwent histologic and cytochemical evaluation for the presence of lymphocyte cell populations and their respective cytokine markers. The mucus samples were evaluated for DNA content. Results: Of the polyps, 42% had an eosinophilic infiltrate, of which 80% had an additional mixed neutrophilic infiltrate. Of the remaining polyp samples, 42% did not have a granulocytic infiltrate, consistent with non-eosinophilic polyps. All samples had CD138-positive plasma cells. The mucus samples from the patients with CF showed higher extracellular DNA concentrations than did the mucus samples from patients with non-CF sinus disease. Conclusions: Cystic fibrosis-related polyps demonstrated an eosinophil-based dichotomy similar to that of idiopathic non-CF-related polyps. Many also demonstrated neutrophilic infiltrate, indicating that chronic mucus stasis and infection complicate the disease. Agents capable of reducing extracellular DNA may help manage sinusitis in CF patients. C1 [Steinke, John W.; Payne, Spencer C.; Negri, Julie; Borish, Larry] Univ Virginia Hlth Syst, Asthma & Allerg Dis Ctr, Carter Immunol Ctr, Dept Med, Charlottesville, VA 22903 USA. [Payne, Spencer C.; Chen, Philip G.] Univ Virginia Hlth Syst, Dept Otolaryngol Head & Neck Surg, Charlottesville, VA USA. [Stelow, Edward B.] Univ Virginia Hlth Syst, Dept Pathol, Charlottesville, VA USA. RP Steinke, JW (reprint author), Univ Virginia Hlth Syst, Asthma & Allerg Dis Ctr, Carter Immunol Ctr, Dept Med, POB 801355, Charlottesville, VA 22903 USA. FU NIH [AI057483, AI090413, AI070364]; Genentech FX From the Asthma and Allergic Disease Center, Carter Immunology Center, Department of Medicine (Steinke, Payne, Negri, Borish), the Department of Otolaryngology-Head and Neck Surgery (Payne, Chen), and the Department of Pathology (Stelow), University of Virginia Health Systems, Charlottesville, Virginia. Supported by NIH grants AI057483, AI090413, and AI070364 and by a medical school basic research grant from Genentech. Genentech is a manufacturer of products; however, this study is not a clinical trial, nor does it involve use of any of the products manufactured by Genentech. There is no basis for there to be any bias. CR Bachert C, 1997, J ALLERGY CLIN IMMUN, V99, P837, DOI 10.1016/S0091-6749(97)80019-X Balsamo R, 2010, Eur Respir Rev, V19, P127, DOI 10.1183/09059180.00003510 BORTS MR, 1989, J ALLERGY CLIN IMMUN, V83, P302 Brinkmann V, 2004, SCIENCE, V303, P1532, DOI 10.1126/science.1092385 Cao PP, 2009, J ALLERGY CLIN IMMUN, V124, P478, DOI 10.1016/j.jaci.2009.05.017 Cimmino M, 2005, ARCH OTOLARYNGOL, V131, P1097, DOI 10.1001/archotol.131.12.1097 Davis PB, 1996, AM J RESP CRIT CARE, V154, P1229 De Gaudemar Isabelle, 1996, Rhinology (Utrecht), V34, P194 Ferguson BJ, 2000, LARYNGOSCOPE, V110, P799, DOI 10.1097/00005537-200005000-00010 Hamilos DL, 1998, CLIN EXP ALLERGY, V28, P1145 HARLIN SL, 1988, J ALLERGY CLIN IMMUN, V81, P867, DOI 10.1016/0091-6749(88)90944-X HENDERSON WR, 1992, J PATHOL, V166, P395, DOI 10.1002/path.1711660412 Mainz JG, 2011, AURIS NASUS LARYNX, V38, P220, DOI 10.1016/j.anl.2010.09.001 NEELY J G, 1972, Transactions of the American Academy of Ophthalmology and Oto-Laryngology, V76, P313 Payne SC, 2011, J ALLERGY CLIN IMMUN, V128, P710, DOI 10.1016/j.jaci.2011.05.022 Payne SC, 2011, LARYNGOSCOPE, V121, P2262, DOI 10.1002/lary.21969 Ponikau JU, 2005, J ALLERGY CLIN IMMUN, V116, P362, DOI 10.1016/j.jaci.2005.03.049 Raynor EM, 2000, ARCH OTOLARYNGOL, V126, P581 Skov M, 1999, PEDIATR PULM, V27, P74, DOI 10.1002/(SICI)1099-0496(199902)27:2<74::AID-PPUL2>3.0.CO;2-L Soler ZM, 2009, OTOLARYNG HEAD NECK, V141, P454, DOI 10.1016/j.otohns.2009.06.085 Steinke JW, 2003, J ALLERGY CLIN IMMUN, V111, P342, DOI 10.1067/mai.2003.67 TOS M, 1977, J LARYNGOL OTOL, V91, P827, DOI 10.1017/S0022215100084449 Vandivier RW, 2002, CHEST, V121, p89S, DOI 10.1378/chest.121.3_suppl.89S Van Zele T, 2006, ALLERGY, V61, P1280, DOI 10.1111/j.1398-9995.2006.01225.x Yousefi S, 2008, NAT MED, V14, P949, DOI 10.1038/nm.1855 NR 25 TC 1 Z9 1 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD SEP PY 2012 VL 121 IS 9 BP 579 EP 586 PG 8 WC Otorhinolaryngology SC Otorhinolaryngology GA 006WZ UT WOS:000308851800004 PM 23012896 ER PT J AU Best, SR Friedman, AD Landau-Zemer, T Barbu, AM Burns, JA Freeman, MW Halvorsen, YD Hillman, RE Zeitels, SM AF Best, Simon R. Friedman, Aaron D. Landau-Zemer, Tali Barbu, Anca M. Burns, James A. Freeman, Mason W. Halvorsen, Yuan-Di Hillman, Robert E. Zeitels, Steven M. TI Safety and Dosing of Bevacizumab (Avastin) for the Treatment of Recurrent Respiratory Papillomatosis SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE Avastin; bevacizumab; glottis; KTP laser; larynx; papilloma; respiratory papillomatosis; toxicity; vocal cord; voice ID KTP LASER TREATMENT; PULSED DYE-LASER; LARYNGEAL PAPILLOMATOSIS; INTERFERON ALFA-N1; INJECTIONS; CIDOFOVIR; INDOLE-3-CARBINOL; ANESTHESIA; DYSPLASIA; CANCER AB Objectives: Increasing evidence supports the use of laryngeal injections of the antiangiogenic agent bevacizumab (Avastin) for the adjuvant treatment of recurrent respiratory papillomatosis (RRP). A recent prospective open-label investigation, approved by the US Food and Drug Administration, employing 12.5 mg of sublesional bevacizumab demonstrated single-site efficacy without complications; however, the safety of multiple-site injections and higher dosing has not yet been reported. The primary objective of this study was to report on the safety of increased doses of bevacizumab for the treatment of RRP. Methods: Two cohorts of adult patients were evaluated. In the first group, a prospective analysis was performed on patients with a diagnosis of laryngeal RRP after their participation in the initial clinical trial with a single-site lower dose (7.5 to 12.5 mg). They received higher doses of sublesional laryngeal bevacizumab (15 to 50 mg total) with detailed physiologic, hematologic, and serum chemistry measurements performed before and after each bevacizumab injection. A second cohort of patients received sublesional laryngeal injections of bevacizumab (15 to 88 mg total) without physiologic measurements and underwent a retrospective analysis of reported complications. Results: One hundred consecutive laryngeal injection sessions (office, 87; operating room, 13) with bevacizumab were performed in 43 patients, with a mean dose of 30 mg total per treatment (range, 15 to 88 mg). Sixty-three of the 100 sessions were accompanied by KTP laser photoangiolysis of the papilloma prior to bevacizumab injections. Eighteen patients (cohort 1) underwent detailed physiologic assessment, and no dysfunction was observed. There were no local or systemic complications of bevacizumab administration. The second group of 25 patients (cohort 2) also reported no significant local or systemic complications. Neither patient group was observed to have a local wound problem in the larynx. Conclusions: This investigation provides evidence that higher doses of bevacizumab are relatively safe in adult patients with laryngeal RRP. Further refinements in pharmacologic concentration and drug delivery will determine the optimal treatment regimens in the future. C1 [Best, Simon R.; Friedman, Aaron D.; Landau-Zemer, Tali; Barbu, Anca M.; Burns, James A.; Hillman, Robert E.; Zeitels, Steven M.] Massachusetts Gen Hosp, Ctr Laryngeal Surg & Voice Rehabil, Boston, MA 02114 USA. [Best, Simon R.; Friedman, Aaron D.; Landau-Zemer, Tali; Barbu, Anca M.; Burns, James A.; Hillman, Robert E.; Zeitels, Steven M.] Harvard Univ, Sch Med, Dept Surg, Cambridge, MA 02138 USA. [Freeman, Mason W.; Halvorsen, Yuan-Di] Harvard Univ, Sch Med, Dept Med, Cambridge, MA 02138 USA. [Freeman, Mason W.; Halvorsen, Yuan-Di] Massachusetts Gen Hosp, Ctr Computat & Integrat Biol, Translat Med Grp, Boston, MA 02114 USA. [Hillman, Robert E.] Massachusetts Gen Hosp, Inst Hlth Profess, Boston, MA 02114 USA. RP Zeitels, SM (reprint author), Massachusetts Gen Hosp, Ctr Laryngeal Surg & Voice Rehabil, 1 Bowdoin Sq,11th Floor, Boston, MA 02114 USA. FU Eugene B. Casey Foundation; V Foundation; Institute of Laryngology and Voice Restoration; Harvard Catalyst Program FX From the Departments of Surgery (Best, Friedman, Landau-Zemer, Barbu, Burns, Hillman, Zeitels) and Medicine (Freeman, Halvorsen), Harvard Medical School, and the Center for Laryngeal Surgery and Voice Rehabilitation (Best, Friedman, Landau-Zemer, Barbu, Burns, Hillman, Zeitels), the Translational Medicine Group, Center for Computational and Integrative Biology (Freeman, Halvorsen), and the MGH Institute of Health Professions (Hillman), Massachusetts General Hospital, Boston, Massachusetts. This work was supported in part by the Eugene B. Casey Foundation, the V Foundation, the Institute of Laryngology and Voice Restoration, and the Harvard Catalyst Program. CR Anderson R R, 1981, Lasers Surg Med, V1, P263 ANDERSON RR, 1983, SCIENCE, V220, P524, DOI 10.1126/science.6836297 Bower CM, 1998, ANN OTO RHINOL LARYN, V107, P1001 Burns JA, 2007, LARYNGOSCOPE, V117, P1500, DOI 10.1097/MLG.0b013e318064e869 Chen S, 2011, LARYNGOSCOPE, V121, P644, DOI 10.1002/lary.21345 Choueiri TK, 2011, J CLIN ONCOL, V29, P632, DOI 10.1200/JCO.2010.31.9129 Coll DA, 1997, AM J OTOLARYNG, V18, P283, DOI 10.1016/S0196-0709(97)90012-0 Eskens FALM, 2008, EUR J CANCER, V44, P2350, DOI 10.1016/j.ejca.2008.07.042 FOLKMAN J, 1985, ADV CANCER RES, V43, P175 Geiger-Gritsch S, 2010, ONCOLOGIST, V15, P1179, DOI 10.1634/theoncologist.2009-0155 HEALY GB, 1988, NEW ENGL J MED, V319, P401, DOI 10.1056/NEJM198808183190704 Hooper FH, 1882, ARCH LARYNGOL, V3, P334 INCZE JS, 1977, CANCER, V39, P1634, DOI 10.1002/1097-0142(197704)39:4<1634::AID-CNCR2820390438>3.0.CO;2-U Karnezis TT, 2011, LARYNGOSCOPE, V121, P636, DOI 10.1002/lary.21415 LEVENTHAL BG, 1991, NEW ENGL J MED, V325, P613, DOI 10.1056/NEJM199108293250904 LEVENTHAL BG, 1988, ARCH OTOLARYNGOL, V114, P1163 Lynch SS, 2007, ANN PHARMACOTHER, V41, P614, DOI 10.1345/aph.1H316 McMillan K, 1998, LARYNGOSCOPE, V108, P968, DOI 10.1097/00005537-199807000-00003 Pransky SM, 2000, ARCH OTOLARYNGOL, V126, P1239 Rahbar R, 2005, ANN OTO RHINOL LARYN, V114, P289 Rosen CA, 1998, OTOLARYNG HEAD NECK, V118, P810, DOI 10.1016/S0194-5998(98)70274-8 Shehab N, 2005, PHARMACOTHERAPY, V25, P977, DOI 10.1592/phco.2005.25.7.977 Snoeck R, 1998, J MED VIROL, V54, P219, DOI 10.1002/(SICI)1096-9071(199803)54:3<219::AID-JMV13>3.0.CO;2-C Van der Reis MI, 2011, RETINA-J RET VIT DIS, V31, P1449, DOI 10.1097/IAE.0b013e3182278ab4 Zeitels SM, 2001, ATLAS PHONOMICROSURG, P119 Zeitels SM, 2004, ANN OTO RHINOL LARYN, V113, P265 Zeitels SM, 2011, ANN OTO RHINOL LARYN, V120, P627 Zeitels SM, 2009, ANN OTOL RHINOL S201, V118, P1 Zeitels SM, 2006, ANN OTO RHINOL LARYN, V115, P679 NR 29 TC 8 Z9 8 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD SEP PY 2012 VL 121 IS 9 BP 587 EP 593 PG 7 WC Otorhinolaryngology SC Otorhinolaryngology GA 006WZ UT WOS:000308851800005 PM 23012897 ER PT J AU Godefroy, WP Klop, WMC Smeele, LE Lohuis, PJFM AF Godefroy, Willem P. Klop, Willem M. C. Smeele, Ludi E. Lohuis, Peter J. F. M. TI Free-Flap Reconstruction of Large Full-Thickness Lip and Chin Defects SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE free flap; full-thickness defect; head and neck reconstruction; lip cancer; lip reconstruction ID RADIAL FOREARM FLAP; FIBULA FREE-FLAP; THIGH FLAP; NECK; HEAD; ARTERY AB Objectives: We describe our experience in the reconstruction of large 3-layer lip defects using free revascularized lower-arm and fibula flaps. Methods: Between 2005 and 2009, nine patients underwent free-flap reconstruction after oncological surgery involving the lip and chin with or without mandibular involvement. The flap techniques are described, and postoperative functional and aesthetic results were recorded. Results: There were no flap failures. All patients showed intact oral function and good aesthetic results. Two patients died of distant metastases, 8 months and 17 months after surgery. Conclusions: Three-layer defects of the lip ideally require free-flap reconstruction, which has a high probability of achieving good functional and aesthetic results. C1 [Klop, Willem M. C.; Smeele, Ludi E.; Lohuis, Peter J. F. M.] Antoni Van Leeuwenhoek Hosp, Dept Head & Neck Oncol & Surg, Netherlands Canc Inst, NL-1066 CX Amsterdam, Netherlands. [Godefroy, Willem P.; Lohuis, Peter J. F. M.] Diakonessen Hosp Zeist Utrecht, Ctr Facial Plast Reconstruct Surg, Zeist, Netherlands. RP Lohuis, PJFM (reprint author), Antoni Van Leeuwenhoek Hosp, Dept Head & Neck Oncol & Surg, Netherlands Canc Inst, Plesmanlaan 121, NL-1066 CX Amsterdam, Netherlands. CR BURGET GC, 1986, PLAST RECONSTR SURG, V78, P583, DOI 10.1097/00006534-198611000-00005 Carroll C M, 2000, Arch Facial Plast Surg, V2, P53, DOI 10.1001/archfaci.2.1.53 Chalian AA, 2001, HEAD NECK-J SCI SPEC, V23, P475, DOI 10.1002/hed.1062 de Bree R, 2008, EUR ARCH OTO-RHINO-L, V265, P1, DOI 10.1007/s00405-007-0413-y Hanasono MM, 2010, ADV THERAPY FACIAL P, P749 HIDALGO DA, 1989, PLAST RECONSTR SURG, V84, P71, DOI 10.1097/00006534-198907000-00014 Jeng SF, 2004, PLAST RECONSTR SURG, V113, P19, DOI 10.1097/01.PRS.0000090722.16689.9A Jeng SF, 2005, PLAST RECONSTR SURG, V115, P1830, DOI 10.1097/01.PRS.0000164688.44223.75 Kimata Y, 1997, ARCH OTOLARYNGOL, V123, P1325 Kroll SS, 1996, PLAST RECONSTR SURG, V98, P459, DOI 10.1097/00006534-199609000-00015 Lee JW, 2006, ANN PLAS SURG, V56, P384, DOI 10.1097/01.sap.0000200283.03650.c3 Miller ME, 2011, ARCH FACIAL PLAST S, V13, P36, DOI 10.1001/archfacial.2010.110 Odell Michael J, 2009, Facial Plast Surg Clin North Am, V17, P203, DOI 10.1016/j.fsc.2009.01.006 Ozdemir R, 2003, J CRANIOFAC SURG, V14, P393 Rosenthal E, 2004, HEAD NECK-J SCI SPEC, V26, P930, DOI 10.1002/hed.20076 SADOVE RC, 1991, PLAST RECONSTR SURG, V88, P209, DOI 10.1097/00006534-199108000-00005 SAKAI S, 1989, BRIT J PLAST SURG, V42, P337, DOI 10.1016/0007-1226(89)90158-6 Salgado C, 2009, FLAPS RECONSTRUCTIVE, P439 SCHUSTERMAN MA, 1992, PLAST RECONSTR SURG, V90, P787, DOI 10.1097/00006534-199211000-00008 SONG RY, 1982, CLIN PLAST SURG, V9, P21 SONG YG, 1984, BRIT J PLAST SURG, V37, P149, DOI 10.1016/0007-1226(84)90002-X TAKADA K, 1987, J ORAL MAXIL SURG, V45, P959, DOI 10.1016/0278-2391(87)90449-6 TAYLOR GI, 1975, PLAST RECONSTR SURG, V55, P533, DOI 10.1097/00006534-197505000-00002 URKEN ML, 1989, ARCH OTOLARYNGOL, V115, P954 Valentini V, 2008, J CRANIOFAC SURG, V19, P1080, DOI 10.1097/SCS.0b013e3181763531 Wei FC, 2001, BRIT J PLAST SURG, V54, P8, DOI 10.1054/bjps.2000.3481 NR 26 TC 0 Z9 0 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD SEP PY 2012 VL 121 IS 9 BP 594 EP 603 PG 10 WC Otorhinolaryngology SC Otorhinolaryngology GA 006WZ UT WOS:000308851800006 PM 23012898 ER PT J AU Mavrogeni, S Bratis, K Kitsiou, A Kolovou, G AF Mavrogeni, Sophie Bratis, Konstantinos Kitsiou, Anastasia Kolovou, Genovefa TI Streptococcal Tonsillitis and Acute Streptococcal Myocarditis: An Unusual Combination Assessed by Cardiac Magnetic Resonance Imaging and Endomyocardial Biopsy SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE cardiac magnetic resonance imaging; nonrheumatic myocarditis; tonsillitis ID ACUTE NONRHEUMATIC MYOPERICARDITIS; COMPLICATING ACUTE TONSILLITIS AB Objectives: Acute streptococcal tonsillitis is occasionally combined with myocarditis. Our aim was to examine patients with tonsillitis in whom myocarditis was suspected by using cardiac magnetic resonance imaging (MRI) and endomyocardial biopsy. Methods: After prospective evaluation of 200 patients with tonsillitis, 17 men (median age, 23 years; age range, 18 to 29 years) were recruited for cardiac MRI because of a suspicion of myocarditis. Chest pain 3 to 5 days after tonsillitis was the main complaint in 15 patients, and atypical chest discomfort in 2 patients. We performed cardiac MRI including short T1 inversion recovery T2-weighted scanning and T1-weighted scanning with early gadolinium enhancement (EGE) and late gadolinium enhancement (LGE). The left ventricular ejection fraction and the presence of myocarditis were evaluated by the standard protocol. A T2 ratio of greater than 2 and an EGE value of greater than 4 were considered abnormal. Heart biopsy was suggested for patients with a reduced left ventricular ejection fraction. Results: Cardiac enzyme levels were increased in 8 of the 17 patients. Increased T2 ratio values (median, 2.8; range, 2.5 to 4.0) were documented in 16 patients. The EGE values were increased (median, 12; range, 8 to 19) in 16 patients. Positive LGE was identified in 13 patients. Endomyocardial biopsy in 4 patients revealed acute myocarditis, and polymerase chain reaction analysis identified streptococcal genomes. Re-evaluation by cardiac MRI 3 months later showed normal results in 14 patients. Conclusions: Acute streptococcal tonsillitis can be occasionally complicated by myocarditis with either a typical or an atypical presentation. Cardiac MRI can facilitate the diagnosis in both forms and allow a noninvasive follow-up. C1 [Kitsiou, Anastasia] Sismanogl Hosp, Cardiac Clin, Athens, Greece. [Mavrogeni, Sophie; Bratis, Konstantinos; Kolovou, Genovefa] Onassis Cardiac Surg Ctr, Cardiac Clin, Athens, Greece. RP Mavrogeni, S (reprint author), 50 Esperou St, Athens 17561, Greece. CR Aretz H T, 1987, Am J Cardiovasc Pathol, V1, P3 Cooper LT, 2007, CIRCULATION, V116, P2216, DOI 10.1161/CIRCULATIONAHA.107.186093 Dressler J, 2004, LARYNGO RHINO OTOL, V83, P593, DOI 10.1055/s-2004-814470 Friedrich MG, 2009, J AM COLL CARDIOL, V53, P1475, DOI 10.1016/j.jacc.2009.02.007 KARJALAINEN J, 1989, CHEST, V95, P359, DOI 10.1378/chest.95.2.359 MAKIIKOLA O, 1994, SCAND J INFECT DIS, V26, P753, DOI 10.3109/00365549409008646 Mavrogeni S, 2011, EUR J HEART FAIL, V13, P830, DOI 10.1093/eurjhf/hfr052 PUTTERMAN C, 1991, CARDIOLOGY, V78, P156, DOI 10.1159/000174780 Ramazzina C, 2005, DEUT MED WOCHENSCHR, V130, P1311, DOI 10.1055/s-2005-868725 Said SAM, 1998, NETH J MED, V53, P266, DOI 10.1016/S0300-2977(98)00100-4 Said SAM, 1999, NETH J MED, V54, P243, DOI 10.1016/S0300-2977(99)00027-3 Talmon Y, 2009, ANN OTO RHINOL LARYN, V118, P556 Talmon Y, 2008, ANN OTO RHINOL LARYN, V117, P295 Winters GL, 2001, CARDIOVASC PATHOL, P256 NR 14 TC 0 Z9 0 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD SEP PY 2012 VL 121 IS 9 BP 604 EP 608 PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA 006WZ UT WOS:000308851800007 PM 23012899 ER PT J AU Murakami, A Tutumi, T Watanabe, K AF Murakami, Atsushi Tutumi, Takesi Watanabe, Kensuke TI Middle Ear Effusion and Fungi SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE Charcot-Leyden crystal; eosinophilic otitis media; fungal hypha; middle ear effusion; otitis media with effusion ID OTITIS-MEDIA; SINUSITIS; EOSINOPHILS; CRYSTALS; CHILDREN; PROTEIN AB Objectives: Bacteria and viruses are rarely isolated from the middle ear fluid in cases of otitis media with effusion (OME). However, since endotoxins are often detected in such effusions, it is suspected that patients with OME have a previous history of gram-negative infection. Recently, fungi have drawn attention as microorganisms that cause chronic sinusitis. We investigated the involvement of fungi in the formation of middle ear effusions of patients with OME and eosinophilic otitis media, in which patients have viscous middle ear effusions and a history of adult bronchial asthma indicating definite involvement of eosinophils. Methods: Middle ear effusions and nasal secretions were collected from patients with eosinophilic otitis media (7 patients) or OME (12 patients), and smears were prepared for methenamine silver staining. The remaining specimens were embedded in Epon and stained with toluidine blue for observation under a light microscope, and ultrathin sections were prepared for examination under an electron microscope. Results: Fungal hyphae were detected in the middle ear fluid in all of the patients with eosinophilic otitis media or OME. Charcot-Leyden crystals (CLCs) were observed in 6 of the 7 patients with eosinophilic otitis media. In regard to the findings in the nasal secretions, fungal hyphae were also detected in the nasal secretions of all patients, whereas CLCs were detected in only 1 patient with eosinophilic otitis media. Conclusions: It was clarified by use of the methenamine silver staining method that fungi were present in the middle ear fluid in 100% of the studied cases of eosinophilic otitis media or OME. Whether fungi are also present in the middle ear cavity of normal persons is unknown, but the possibility that they may contribute as a cause of both diseases cannot be excluded. Particularly in eosinophilic otitis media, the observation of numerous CLCs in the middle ear fluid suggests that many eosinophils have degenerated. The eosinophil granule proteins released from the degenerated eosinophils can cause epithelial injury of the middle ear. The possibility that fungi induce the eosinophils in the middle ear also cannot be excluded. C1 [Murakami, Atsushi; Tutumi, Takesi; Watanabe, Kensuke] Dokkyo Med Univ Koshigaya Hosp, Dept Otorhinolaryngol, Koshigaya, Japan. RP Watanabe, K (reprint author), 2-14-5 Nishihara Shibuya Ku, Tokyo, Japan. CR Brook I, 2005, J LARYNGOL OTOL, V119, P251 Calafat J, 1997, EUR J HAEMATOL, V58, P56 Catten MD, 2001, LARYNGOSCOPE, V111, P399, DOI 10.1097/00005537-200103000-00006 Faden H, 1997, J INFECT DIS, V175, P1440 GOURLEY DS, 1990, J ALLERGY CLIN IMMUN, V85, P583, DOI 10.1016/0091-6749(90)90097-N Guo L, 2000, J BIOL CHEM, V275, P8032, DOI 10.1074/jbc.275.11.8032 KATZENSTEIN ALA, 1983, J ALLERGY CLIN IMMUN, V72, P89, DOI 10.1016/0091-6749(83)90057-X Kim EJ, 2002, LARYNGOSCOPE, V112, P2037, DOI 10.1097/00005537-200211000-00023 KRAFT M, 1995, EUR RESPIR J, V8, P1966, DOI 10.1183/09031936.95.08111966 KUO TT, 1988, AM J SURG PATHOL, V12, P843, DOI 10.1097/00000478-198811000-00005 LETHEM MI, 1990, AM REV RESPIR DIS, V142, P1053 Matsutani S, 1995, OTOLARYNGOL HEAD NEC, V67, P712 Nagamine H, 2002, AURIS NASUS LARYNX, V29, P19, DOI 10.1016/S0385-8146(01)00124-9 Ponikau JU, 1999, MAYO CLIN PROC, V74, P877 Rosenblut A, 2001, PEDIATR INFECT DIS J, V20, P501, DOI 10.1097/00006454-200105000-00006 Shambaugh GE, 1980, SURG EAR, P207 Watanabe K, 2004, ANN OTO RHINOL LARYN, V113, P200 Watanabe K, 2003, ANN OTO RHINOL LARYN, V112, P169 WELLER PF, 1982, J IMMUNOL, V128, P1346 NR 19 TC 2 Z9 4 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD SEP PY 2012 VL 121 IS 9 BP 609 EP 614 PG 6 WC Otorhinolaryngology SC Otorhinolaryngology GA 006WZ UT WOS:000308851800008 PM 23012900 ER PT J AU Gorgulu, O Ozdemir, S Canbolat, EP Sayar, C Olgun, MK Akbas, Y AF Gorgulu, Orhan Ozdemir, Suleyman Canbolat, Emre Polat Sayar, Cagdas Olgun, Mustafa Kemal Akbas, Yucel TI Analysis of the Roles of Smoking and Allergy in Nasal Polyposis SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE allergy; immunoglobulin E; nasal polyp; serum cotinine; smoking; tobacco ID ENVIRONMENTAL TOBACCO-SMOKE; SERUM COTININE; RHINITIS; EXPOSURE; POPULATION; MARKER AB Objectives: Recent studies on the etiopathogenesis of nasal polyps have shown that smoking and nonallergenic inhalants such as occupational dust exposure cause chronic inflammation of the nasal mucosa. These factors may be associated with nasal polyps. The aim of this study was to use laboratory tests to investigate the effects of smoking and allergens on the development of nasal polyps. Methods: The study included 60 consecutive patients with a diagnosis of nasal polyposis who were treated with functional endoscopic sinus surgery at our clinic and 25 smoker and 25 nonsmoker participants who constituted a control group. Results: In the patient and control groups, the mean absorbance value for cotinine in smokers was found to be statistically significantly lower than that in nonsmokers. There was a significant difference between the groups with respect to blood cotining positivity. No significant difference was found between the groups in terms of allergy parameters. In the regression model, smoking was found to be the only significant risk factor for the development of nasal polyps, independent of smoking duration, absorbance value, or cotinine positivity. Conclusions: Smoking restriction and avoiding exposure to cigarette smoke by patients with nasal polyps may be an important strategy in the prevention and recurrence of nasal polyposis. No direct relationship was determined between allergy and nasal polyposis. C1 [Gorgulu, Orhan; Canbolat, Emre Polat; Sayar, Cagdas; Olgun, Mustafa Kemal] Adana Numune Educ & Res Hosp, Dept Otorhinolaryngol, Adana, Turkey. [Ozdemir, Suleyman] Cukurova Univ, Sch Med, Dept Otorhinolaryngol, Adana, Turkey. [Akbas, Yucel] Adana Galeria ENT Hosp, Dept Otorhinolaryngol, Adana, Turkey. RP Gorgulu, O (reprint author), Huzurevleri Mah Turkmenbasi Bul Akgul 5 Sit A Blo, TR-01500 Adana, Turkey. CR Asero R, 2001, ANN ALLERG ASTHMA IM, V86, P283 Bateman ND, 2003, J LARYNGOL OTOL, V117, P1 Ciprandi G, 2008, LARYNGOSCOPE, V118, P385, DOI 10.1097/MLG.0b013e31815dd50b Collins MM, 2002, CLIN OTOLARYNGOL, V27, P314, DOI 10.1046/j.1365-2273.2002.00573.x ECCLES R, 1995, EUR ARCH OTO-RHINO-L, V252, pS2, DOI 10.1007/BF02484428 Houser SM, 2008, LARYNGOSCOPE, V118, P1521, DOI 10.1097/MLG.0b013e31817d01b8 Ilicali OC, 1999, ARCH OTOLARYNGOL, V125, P758 Johansson L, 2004, ACTA OTO-LARYNGOL, V124, P77, DOI 10.1080/00016480310016037 Moerloose KB, 2006, RESP RES, V7, DOI 10.1186/1465-9921-7-49 PIERCE JP, 1987, J CHRON DIS, V40, P689, DOI 10.1016/0021-9681(87)90105-6 Pirkle James L., 1996, JAMA (Journal of the American Medical Association), V275, P1233, DOI 10.1001/jama.275.16.1233 Seccareccia F, 2003, EUR J EPIDEMIOL, V18, P487 SETTIPANE GA, 1977, J ALLERGY CLIN IMMUN, V59, P17, DOI 10.1016/0091-6749(77)90171-3 Sin A, 1997, J INVEST ALLERG CLIN, V7, P234 SLAVIN RG, 1992, ARCH OTOLARYNGOL, V118, P771 Slavin RG, 1997, ALLERGIC DIS, P448 Therriault MJ, 2003, CLIN EXP IMMUNOL, V132, P232, DOI 10.1046/j.1365-2249.2003.02142.x Vento SI, 2000, ANN ALLERG ASTHMA IM, V85, P209 WELCH AR, 1995, J LARYNGOL OTOL, V109, P104 WHITTET HB, 1991, J LARYNGOL OTOL, V105, P1036, DOI 10.1017/S0022215100118146 NR 20 TC 5 Z9 5 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD SEP PY 2012 VL 121 IS 9 BP 615 EP 619 PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA 006WZ UT WOS:000308851800009 PM 23012901 ER PT J AU Chang, SS Goldenberg, D Koch, WM AF Chang, Steven S. Goldenberg, David Koch, Wayne M. TI Transcervical Approach to Benign Parapharyngeal Space Tumors SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE benign tumor; neck mass; parapharyngeal space; pleomorphic adenoma; transcervical approach ID SURGICAL-MANAGEMENT; MASSES AB Objectives: We describe our experience with the postoperative sequelae, complications, and recurrences associated with resection of a series of parapharyngeal space (PPS) tumors via a transcervical approach without submandibular gland excision, parotidectomy, or mandibulotomy. Methods: We performed a retrospective review of 51 cases, 40 of which were pleomorphic adenomas and 11 of which were lipomas or schwannomas. Results: Of 30 fine-needle aspirations performed, 24 indicated pleomorphic adenoma before operation. Twenty-eight of the 30 fine-needle aspirations yielded diagnoses that were consistent with the final pathologic diagnoses. The average hospital stay was 1.05 days. After operation, there were 9 cases of trismus, 4 cases of "first bite" pain, and 7 cases of transient marginal nerve weakness. There were no recurrences over an average follow-up of 115 months. Conclusions: The majority of PPS tumors are benign. It is important to use an approach that allows complete tumor excision but does not impart undue postoperative morbidity. We demonstrate that the transcervical approach without submandibular gland excision, parotidectomy, or mandibulotony is ideal for benign PPS tumors. C1 [Chang, Steven S.; Koch, Wayne M.] Johns Hopkins Med Inst, Dept Otolaryngol Head & Neck Surg, Baltimore, MD 21287 USA. [Goldenberg, David] Penn State Milton S Hershey Med Ctr, Div Otolaryngol Head & Neck Surg, Hershey, PA USA. RP Koch, WM (reprint author), Johns Hopkins Med Inst, Dept Otolaryngol Head & Neck Surg, 601 N Caroline St,Room 6254, Baltimore, MD 21287 USA. CR BATSAKIS JG, 1989, ANN OTO RHINOL LARYN, V98, P320 CARRAU RL, 1990, LARYNGOSCOPE, V100, P583 Cohen SM, 2005, HEAD NECK-J SCI SPEC, V27, P669, DOI 10.1002/hed.20199 CROSS RR, 1989, RADIOL CLIN N AM, V27, P353 Eisele DE, 1999, HEAD NECK-J SCI SPEC, V21, P154, DOI 10.1002/(SICI)1097-0347(199903)21:2<154::AID-HED9>3.0.CO;2-W Hamza A, 1997, ARCH OTOLARYNGOL, V123, P622 Khafif A, 2005, OTOLARYNG HEAD NECK, V132, P401, DOI 10.1016/j.otohns.2004.09.062 Malone JP, 2001, ANN OTO RHINOL LARYN, V110, P1093 O'Malley BW, 2010, ORL J OTO-RHINO-LARY, V72, P332, DOI 10.1159/000320596 Som P M, 1981, Ann Otol Rhinol Laryngol Suppl, V90, P3 SOM PM, 1988, RADIOLOGY, V169, P81 STELL PM, 1985, AM J OTOLARYNG, V6, P92, DOI 10.1016/S0196-0709(85)80045-4 NR 12 TC 5 Z9 5 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD SEP PY 2012 VL 121 IS 9 BP 620 EP 624 PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA 006WZ UT WOS:000308851800010 PM 23012902 ER PT J AU de Jong, MA Perez, R Adelman, C Sohmer, H AF de Jong, Marrigje A. Perez, Ronen Adelman, Cahtia Sohmer, Haim TI Experimental Exploration of the Soft Tissue Conduction Pathway From Skin Stimulation Site to Inner Ear SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE acoustic impedance; air conduction; bone conduction; middle ear; soft tissue conduction; threshold ID BONE-CONDUCTION AB Objectives: Auditory sensation can be elicited by air conduction (AC) and by bone conduction (BC). It is also possible to elicit such responses by applying the standard clinical bone vibrator to the skin over soft tissue sites on the head, neck, or thorax of humans and animals. This mode of auditory stimulation has been called soft tissue conduction (STC). This study was designed to investigate the pathway between soft tissue sites and the ear. Methods: The air in the middle ear was replaced with saline solution in an animal with unique anatomy the fat sand rat, in which about 70% of a thin-walled inner ear bulges into the middle ear bulla cavity while we recorded the auditory brain stem responses (ABRs) to AC, BC, and STC stimulation. Results: This replacement of air with saline solution led to a significant improvement in SIC threshold. With AC stimulation, the ABR threshold was elevated and the latency of the first ABR wave was prolonged. Consistent changes were not seen with BC stimulation. Conclusions: When the air (which has a very low acoustic impedance) that no rmally surrounds most of the inner ear is replaced with saline solution (which has an acoustic impedance similar to that of soft tissues), the SIC threshold is improved. This improvement may be clue to improved transmission of acoustic energy from the soft tissues to the inner ear. C1 [de Jong, Marrigje A.; Sohmer, Haim] Hebrew Univ Jerusalem, Hadassah Med Sch, Dept Med Neurobiol Physiol, Inst Med Res Israel Canada, IL-91120 Jerusalem, Israel. [Perez, Ronen] Shaare Zedek Med Ctr, Dept Otolaryngol Head & Neck Surg, Jerusalem, Israel. [Adelman, Cahtia] Hadassah Univ Hosp, Speech & Hearing Ctr, IL-91120 Jerusalem, Israel. RP Sohmer, H (reprint author), Hebrew Univ Jerusalem, Hadassah Med Sch, Dept Physiol, POB 12272, IL-91120 Jerusalem, Israel. CR Adelman C, 2011, EUR ARCH OTO-RHINO-L, V269, P425 Baun J., 2004, PHYS PRINCIPLES GEN CHISIN R, 1983, ARCH OTO-RHINO-LARYN, V237, P165, DOI 10.1007/BF00463617 Chordekar S, 2012, HEARING RES, V283, P180, DOI 10.1016/j.heares.2011.10.004 de Jong Marrigje, 2011, Journal of Basic and Clinical Physiology and Pharmacology, V22, P55, DOI [10.1515/jbcpp.2011.014, 10.1515/JBCPP.2011.014] Ito T, 2011, AUDIOL NEURO-OTOL, V16, P12, DOI 10.1159/000314282 MELZER P, 1984, HEARING RES, V15, P187, DOI 10.1016/0378-5955(84)90050-9 Perez R, 2011, J BAS CLIN PHYS PHAR, V22, P82 Perez R, 2011, HEARING RES, V280, P82, DOI 10.1016/j.heares.2011.04.007 Sichel JY, 1999, J OTOLARYNGOL, V28, P217 Sohmer H, 1976, ELECTROCOCHLEOGRAPHY, P431 Vento B. A., 2009, HDB CLIN AUDIOLOGY, P50 Wever EG, 1954, PHYSL ACOUSTICS NR 13 TC 3 Z9 4 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD SEP PY 2012 VL 121 IS 9 BP 625 EP 628 PG 4 WC Otorhinolaryngology SC Otorhinolaryngology GA 006WZ UT WOS:000308851800011 PM 23012903 ER PT J AU Kayhan, FT Kaya, KH Sayin, I AF Kayhan, Fatma Tulin Kaya, Kamil Hakan Sayin, Ibrahim TI Transoral Robotic Cordectomy for Early Glottic Carcinoma SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE da Vinci Surgical System; early glottic cancer; robotic surgery ID UPPER AERODIGESTIVE TRACT; LASER MICROSURGERY; MARGIN-STATUS; SURGERY TORS; BASE; RADIOTHERAPY; LARYNGEAL; NEOPLASMS; CANCER AB Objectives: We assessed the feasibility, safety, and efficacy of transoral cordectomy performed for early glottic cancer with the da Vinci Surgical System. Methods: Subjects with early cancer of the vocal cords who were treated with transoral robot-assisted cordectomy were included for study. Data regarding the ability to perform robot-assisted resection, volume of blood loss, robotic operating time, pathological margin status, postoperative extubation, complications, length of hospitalization, duration until start of oral nutrition, and need for a tracheotomy were evaluated. Results: Ten men with TI glottic carcinoma underwent successful transoral robotic corclectomy with negative margins. The mean total robotic surgery time was 21.6 +/- 6.75 minutes (range, 10 to 31 minutes). In all cases, the total blood loss was less than 20 mL. One subject needed a short-term tracheotomy and a nasogastric tube. The other 9 subjects started oral nutrition 6 to 24 hours after operation. The mean duration of hospitalization was 4.1 +/- 2.23 days. Conclusions: Transoral robotic corclectomy with the da Vinci Surgical System was found to be feasible, relatively safe, and effective. The lower morbidity rate was an advantage of this method. Transom, robotic surgery provides better exposure, visualization, and access than does transoral laser microsurgery. Cordectomy with transoral robotic surgery should be an alternative to external-approach cordectomy and transoral laser microsurgery. C1 [Kayhan, Fatma Tulin; Kaya, Kamil Hakan; Sayin, Ibrahim] Bakirkoy Dr Sadi Konuk Training & Res Hosp, Dept Otolaryngol Head & Neck Surg, Istanbul, Turkey. RP Sayin, I (reprint author), Bakirkoy Dr Sadi Konuk Training & Res Hosp, Dept Otolaryngol Head & Neck Surg, Tevfik Saglam Caddesi 11, TR-34147 Bakirkoy Istanbul, Turkey. CR Alessandrini M, 2008, EUR ARCH OTO-RHINO-L, V265, P1121, DOI 10.1007/s00405-008-0718-5 Ansarin M, 2009, ARCH OTOLARYNGOL, V135, P385, DOI 10.1001/archoto.2009.10 Blanco RGF, 2011, J LAPAROENDOSC ADV S, V21, P157, DOI 10.1089/lap.2010.0350 Boudreaux BA, 2009, ARCH OTOLARYNGOL, V135, P397, DOI 10.1001/archoto.2009.24 Desai SC, 2008, LARYNGOSCOPE, V118, P2187, DOI 10.1097/MLG.0b013e31818379e4 Hockstein NG, 2005, LARYNGOSCOPE, V115, P1003, DOI 10.1212/01.WNL.0000164714.90354.7D Hockstein NG, 2005, LARYNGOSCOPE, V115, P7805 Kayhan FT, 2011, J CRANIOFAC SURG, V22, P1000, DOI 10.1097/SCS.0b013e3182101580 Kayhan FT, 2011, J ORAL MAXIL SURG, V69, P2904, DOI 10.1016/j.joms.2011.01.049 Kayhan Fatma Tülin, 2014, Indian J Otolaryngol Head Neck Surg, V66, P385, DOI 10.1007/s12070-011-0335-2 Ledda GP, 2006, OTOLARYNG HEAD NECK, V134, P911, DOI 10.1016/j.otohns.2005.10.049 Machtay M, 1997, HEAD NECK-J SCI SPEC, V19, P494, DOI 10.1002/(SICI)1097-0347(199709)19:6<494::AID-HED6>3.0.CO;2-U Mendenhall WM, 2004, CANCER, V100, P1786, DOI 10.1002/cncr.20181 O'Malley BW, 2006, LARYNGOSCOPE, V116, P1465, DOI 10.1097/01.mlg.0000227184.90514.1a Park YM, 2009, J LAPAROENDOSC ADV S, V19, P361, DOI 10.1089/lap.2008.0320 Petruzzelli GJ, 2009, EXPERT REV MED DEVIC, V6, P599, DOI [10.1586/erd.09.49, 10.1586/ERD.09.49] Thurnher D, 2008, EJSO-EUR J SURG ONC, V34, P692, DOI 10.1016/j.ejso.2007.06.008 Vicini C, 2010, ORL J OTO-RHINO-LARY, V72, P22, DOI 10.1159/000284352 Weinstein GS, 2007, ARCH OTOLARYNGOL, V133, P1220, DOI 10.1001/archotol.133.12.1220 Weinstein GS, 2009, CURR OPIN OTOLARYNGO, V17, P126, DOI 10.1097/MOO.0b013e32832924f5 Weinstein GS, 2007, ANN OTO RHINOL LARYN, V116, P19 NR 21 TC 11 Z9 11 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD AUG PY 2012 VL 121 IS 8 BP 497 EP 502 PG 6 WC Otorhinolaryngology SC Otorhinolaryngology GA 991HE UT WOS:000307691300001 PM 22953654 ER PT J AU Sieskiewicz, A Lyson, T Piszczatowski, B Rogowski, M AF Sieskiewicz, Andrzej Lyson, Tomasz Piszczatowski, Bartosz Rogowski, Marek TI Endoscopic Treatment of Adversely Located Osteomas of the Frontal Sinus SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE endoscopic treatment; frontal sinus; osteoma ID PARANASAL SINUSES; LOTHROP PROCEDURE; MANAGEMENT; SURGERY; OBLITERATION; TREPHINATION; TUMORS; LIMITS AB Objectives: We assess the utility and limitations of an endoscopic technique in the treatment of osteomas that are considered difficult to manage endoscopically, ie, those located superiorly or laterally in the frontal sinus, extending beyond a virtual plane through the lamina papyracea, and we describe the principles of a surgical technique that facilitates removal of such tumors. Methods: We performed a retrospective study on 8 patients with symptomatic frontal sinus osteomas, including tumors extending past the commonly recognized limits of endoscopic resection because of their size or site of attachment. Results: All tumors were removed by a purely transnasal endoscopic approach. No major complications were observed during or after the operation. All patients experienced improvement or total regression of their symptoms. Conclusions: With appropriate instruments and specific endoscopic techniques, it is possible to resect osteomas that not long ago were deemed inaccessible to endoscopic surgeons. The commonly recognized limits of endoscopic treatment of such tumors may be exceeded in some cases; however, favorable anatomic conditions are decisive for a successful operation. C1 [Sieskiewicz, Andrzej; Piszczatowski, Bartosz; Rogowski, Marek] Univ Hosp Bialystok, Dept Otolaryngol Head & Neck Surg, PL-15276 Bialystok, Poland. [Lyson, Tomasz] Univ Hosp Bialystok, Dept Neurosurg, PL-15276 Bialystok, Poland. RP Sieskiewicz, A (reprint author), Univ Hosp Bialystok, Dept Otolaryngol Head & Neck Surg, Sklodowskiej Curie 24 A, PL-15276 Bialystok, Poland. FU Ministry of Science and Education, Warsaw, Poland [NR13 0037 10] FX From the Departments of Otolaryngology-Head and Neck Surgery (Sieskiewicz, Piszczatowski, Rogowski) and Neurosurgery (Lyson), University Hospital of Bialystok, Bialystok, Poland. Sponsored by grant NR13 0037 10 from the Ministry of Science and Education, Warsaw, Poland. CR Becker SS, 2006, OTOLARYNG HEAD NECK, V135, P917, DOI 10.1016/j.otohns.2006.03.046 Bignami M, 2007, RHINOLOGY, V45, P315 Briner HR, 2005, AM J RHINOL, V19, P269 Castelnuovo P, 2006, RHINOLOGY, V44, P2 Chen C, 2004, RHINOLOGY, V42, P239 Chiu AG, 2005, AM J RHINOL, V19, P191 FU YS, 1974, CANCER, V33, P1289, DOI 10.1002/1097-0142(197405)33:5<1289::AID-CNCR2820330514>3.0.CO;2-P GROSS WE, 1995, OTOLARYNG HEAD NECK, V113, P427, DOI 10.1016/S0194-5998(95)70080-3 Koivunen P, 1997, CLIN OTOLARYNGOL, V22, P111, DOI 10.1046/j.1365-2273.1997.00869.x Ledderose GJ, 2011, EUR ARCH OTO-RHINO-L, V268, P525, DOI 10.1007/s00405-010-1384-y Lund VJ, 2010, RHINOL S, V22, P1 Schick B, 2001, RHINOLOGY, V39, P66 Seiberling K, 2009, AMJ RHINOL ALLERGY, V23, P331, DOI 10.2500/ajra.2009.23.3321 SEIDEN AM, 1995, OTOLARYNG HEAD NECK, V112, P607, DOI 10.1177/019459989511200419 Selva D, 2004, SURV OPHTHALMOL, V49, P328, DOI 10.1016/j.survophthal.2004.02.011 Weber R, 2001, LARYNGOSCOPE, V111, P137, DOI 10.1097/00005537-200101000-00024 Weber R, 2000, LARYNGOSCOPE, V110, P1037, DOI 10.1097/00005537-200006000-00028 Zacharek MA, 2006, OTOLARYNG HEAD NECK, V135, P518, DOI 10.1016/j.otohns.2006.05.033 NR 18 TC 1 Z9 1 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD AUG PY 2012 VL 121 IS 8 BP 503 EP 509 PG 7 WC Otorhinolaryngology SC Otorhinolaryngology GA 991HE UT WOS:000307691300002 PM 22953655 ER PT J AU Evankovich, J Dedhia, RC Bastaki, JM Tublin, M Johnson, JT AF Evankovich, John Dedhia, Raj C. Bastaki, Jassem M. Tublin, Mitchell Johnson, Jonas T. TI Primary Sclerosing Paraganglioma of the Thyroid Gland: A Case Report SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE paraganglioma; sclerosing paraganglioma; thyroid mass ID NECK PARAGANGLIOMAS; MANAGEMENT; EXPERIENCE; NODULES; HEAD; ULTRASOUND AB Objectives: Paragangliomas are neuroendocrine tumors derived from extra-adrenal paraganglionic cells of the autonomic nervous system. Paragangliomas of the thyroid are rare, with only 28 cases reported in the literature. The sclerosing paraganglioma variant, characterized by marked stromal sclerosis and hyalinization, has scarcely been reported. Methods: A 36-year-old woman with a history of a 1-cm vagal schwannoma followed with serial magnetic resonance imaging presented with a new solitary 2.5-cm enhancing soft tissue mass in the left thyroid. Results: Ultrasound examination of the thyroid revealed a hypoechoic, hypervascular, malignant-appearing mass. Two fine-needle aspirations were insufficient for diagnosis, and the mass was deemed a lesion of undetermined significance with subsequent indeterminate molecular testing. A diagnostic left thyroid lobectomy was performed, and pathologic examination revealed a lesion consistent with a sclerosing paraganglioma. Conclusions: Sclerosing paragangliomas are rare tumors, and only 1 case involving a primary thyroid mass has been reported in the literature. Although the sclerosing variant has features suggestive of malignancy, the true incidence of malignancy is unknown, given the rarity of its presentation. However, given the overall benign nature of paragangliomas, the sclerosing variant is also likely benign, despite its malignant features on ultrasound and histopathologic examination. C1 [Johnson, Jonas T.] Univ Pittsburgh, Sch Med, Eye & Ear Infirm, Dept Otolaryngol, Pittsburgh, PA 15213 USA. [Bastaki, Jassem M.] Univ Pittsburgh, Med Ctr, Dept Pathol, Pittsburgh, PA 15213 USA. [Tublin, Mitchell] Univ Pittsburgh, Med Ctr, Dept Radiol, Pittsburgh, PA 15213 USA. RP Johnson, JT (reprint author), Univ Pittsburgh, Sch Med, Eye & Ear Infirm, Dept Otolaryngol, 200 Lothrop St,Suite 500, Pittsburgh, PA 15213 USA. CR Cooper DS, 2010, THYROID, V20, P674, DOI 10.1089/thy.2009.0110.cxn Bailey BJ, 2006, HEAD NECK SURG OTOLA Baysal BE, 2002, J MED GENET, V39, P617, DOI 10.1136/jmg.39.9.617 Chapman DB, 2010, OTOLARYNG HEAD NECK, V143, P531, DOI 10.1016/j.otohns.2010.05.031 Cooper DS, 2009, THYROID, V19, P1167, DOI 10.1089/thy.2009.0110 Cooper DS, 2010, THYROID, V20, P942, DOI 10.1089/thy.2009.0110.cxn2 Erem C, 2009, ENDOCRINE, V36, P368, DOI 10.1007/s12020-009-9238-3 Frates MC, 2005, RADIOLOGY, V237, P794, DOI 10.1148/radiol.2373050220 Gharib H, 2008, ENDOCR PRACT, V14, P802 Gharib Hossein, 2006, Endocr Pract, V12, P63 Hinerman RW, 2008, HEAD NECK-J SCI SPEC, V30, P1431, DOI 10.1002/hed.20885 Isik ACU, 2006, EUR ARCH OTO-RHINO-L, V263, P23, DOI 10.1007/s00405-004-0885-y Karaman E, 2010, J CRANIOFAC SURG, V21, P117, DOI 10.1097/SCS.0b013e3181c466ce Layfield LJ, 2009, DIAGN CYTOPATHOL, V37, P710, DOI 10.1002/dc.21093 Moskovic DJ, 2010, HEAD NECK ONCOL, V2, DOI 10.1186/1758-3284-2-23 Mukhopadhyay S, 2006, AM J SURG PATHOL, V30, P1206 Nayar R, 2009, CANCER CYTOPATHOL, V117, P195, DOI 10.1002/cncy.20029 Orija Israel B, 2007, Endocr Pract, V13, P735 Papaspyrou K, 2009, HEAD NECK-J SCI SPEC, V31, P381, DOI 10.1002/hed.20967 Phitayakorn R, 2011, THYROID, V21, P725, DOI 10.1089/thy.2010.0362 Plaza JA, 2006, AM J SURG PATHOL, V30, P7, DOI 10.1097/01.pas.0000174012.37439.c7 Rago T, 2008, BEST PRACT RES CL EN, V22, P913, DOI 10.1016/j.beem.2008.09.016 Somasundar P, 2000, J SURG ONCOL, V74, P286, DOI 10.1002/1096-9098(200008)74:4<286::AID-JSO9>3.0.CO;2-C Tessler FN, 1999, AM J ROENTGENOL, V173, P437 TUNBRIDGE WMG, 1977, CLIN ENDOCRINOL, V7, P481, DOI 10.1111/j.1365-2265.1977.tb01340.x VANDER JB, 1968, ANN INTERN MED, V69, P537 NR 26 TC 2 Z9 2 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD AUG PY 2012 VL 121 IS 8 BP 510 EP 515 PG 6 WC Otorhinolaryngology SC Otorhinolaryngology GA 991HE UT WOS:000307691300003 PM 22953656 ER PT J AU Lan, Y Ohkubo, M Berretin-Felix, G Sia, I Carnaby-Mann, GD Crary, MA AF Lan, Yue Ohkubo, Mai Berretin-Felix, Giedre Sia, Isaac Carnaby-Mann, Giselle D. Crary, Michael A. TI Normalization of Temporal Aspects of Swallowing Physiology After the McNeill Dysphagia Therapy Program SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE deglutition; dysphagia; manometry; swallowing; temporal coordination; timing ID UPPER ESOPHAGEAL SPHINCTER; HIGH-RESOLUTION MANOMETRY; PRESSURE EVENTS; PHARYNGEAL; VISCOSITY; DISEASE; STROKE; HEAD; AGE; ABNORMALITIES AB Objectives: We examined the timing of physiological swallowing events in patients before and after completion of an exercise-based dysphagia intervention (McNeill Dysphavia Therapy Program; MDTP) and compared their performance to that of healthy volunteers. Methods: Eight adults (mean age, 57.5 years) with chronic dysphagia (mean, 45 months) completed 3 weeks of the MDTP. Before and after the MDTP we measured lingual-palatal and pharyngeal manometric pressures during swallows of thin liquid, thick liquid, and pudding material in 5-mL volumes. Using the pressure peak of the pharyngoesophageal segment clearing wave as the anchor point, we measured the relative timing of pressure peaks from the anterior, middle, and posterior parts of the tongue and the manometric peaks from the base of the tongue, the hypopharynx, and the nadir of the pharyngoesophageal segment. We compared these results to identical measures obtained from 34 healthy adults (mean age, 44.0 years). Results: The timing of physiological events before the MDTP was significantly slower than that of the group of healthy volunteers. The timing data from after the MDTP were not significantly different from those of the healthy group. The magnitude change was greatest for thin liquid. Conclusions: Dysphagia therapy with the MDTP improves the timing of physiological events during swallowing. Temporal coordination of swallowing components after therapy approximates that of healthy adults, suggesting a normalization of swallow timing after the MDTP. C1 [Lan, Yue; Ohkubo, Mai; Berretin-Felix, Giedre; Sia, Isaac; Crary, Michael A.] Univ Florida, Coll Publ Hlth & Hlth Profess, Dept Speech Language & Hearing Sci, Gainesville, FL 32610 USA. [Carnaby-Mann, Giselle D.] Univ Florida, Coll Publ Hlth & Hlth Profess, Dept Behav Sci & Community Hlth, Gainesville, FL 32610 USA. RP Crary, MA (reprint author), Univ Florida, Coll Publ Hlth & Hlth Profess, Dept Speech Language & Hearing Sci, POB 100174, Gainesville, FL 32610 USA. RI Berretin-Felix, Giedre/C-6482-2012 CR Barry BK, 2005, J GERONTOL A-BIOL, V60, P232 BISCH EM, 1994, J SPEECH HEAR RES, V37, P1041 Butler SG, 2009, J SPEECH LANG HEAR R, V52, P240, DOI 10.1044/1092-4388(2008/07-0092) Carnaby-Mann GD, 2010, ARCH PHYS MED REHAB, V91, P743, DOI 10.1016/j.apmr.2010.01.013 Carnaby-Mann GD, 2008, ANN OTO RHINOL LARYN, V117, P279 CASTELL JA, 1995, DYSPHAGIA, V10, P22, DOI 10.1007/BF00261275 Castell JA, 1997, DIGEST DIS, V15, P28, DOI 10.1159/000171619 Clave P, 2006, ALIMENT PHARM THERAP, V24, P1385, DOI 10.1111/j.1365-2036.2006.03118.x Crary MA, 1997, DYSPHAGIA, V12, P180, DOI 10.1007/PL00009534 Crary MA, 2012, ARCH PHYS MED REHABI Crary MA, 2005, ARCH PHYS MED REHAB, V86, P1516, DOI 10.1016/j.apmr.2004.11.049 Ding RY, 2003, J SPEECH LANG HEAR R, V46, P977, DOI 10.1044/1092-4388(2003/076) dos Santos CM, 2011, DYSPHAGIA, V26, P361, DOI 10.1007/s00455-010-9321-1 Eisbruch A, 2002, INT J RADIAT ONCOL, V53, P23, DOI 10.1016/S0360-3016(02)02712-8 FOLSTEIN MF, 1975, J PSYCHIAT RES, V12, P189, DOI 10.1016/0022-3956(75)90026-6 Fox M, 2004, NEUROGASTROENT MOTIL, V16, P533, DOI 10.1111/j.1365-2982.2004.00539.x Gabriel DA, 2006, SPORTS MED, V36, P133, DOI 10.2165/00007256-200636020-00004 Gallas S, 2010, DYSPHAGIA, V25, P291, DOI 10.1007/s00455-009-9259-3 Groher ME, 2010, DSYPHAGIA CLIN MANAG Hiss SG, 2005, DYSPHAGIA, V20, P149, DOI 10.1007/s00455-005-0008-y Kendall KA, 2000, DYSPHAGIA, V15, P74 Kendall KA, 2000, ANN OTO RHINOL LARYN, V109, P767 KRIEGER IM, 1953, J APPL PHYS, V24, P134, DOI 10.1063/1.1721226 Li S, 2009, J NEUROL NEUROSUR PS, V80, P1320, DOI 10.1136/jnnp.2009.176214 Mann G. D., 2002, MASA MANN ASSESSMENT McCulloch TM, 2010, ANN OTO RHINOL LARYN, V119, P369 Mielens JD, 2011, DYSPHAGIA, V26, P3, DOI 10.1007/s00455-010-9320-2 MORGAN M, 1994, J GERONTOL, V49, pM133 Olsson R, 1997, ACAD RADIOL, V4, P349, DOI 10.1016/S1076-6332(97)80116-X Regan J, 2010, DYSPHAGIA, V25, P207, DOI 10.1007/s00455-009-9244-x Robey RR, 2004, J COMMUN DISORD, V37, P401, DOI 10.1016/j.comdis.2004.04.003 Rofes L, 2010, NEUROGASTROENT MOTIL, V22, P851, DOI 10.1111/j.1365-2982.2010.01521.x Rosenbek JC, 1996, DYSPHAGIA, V11, P225, DOI 10.1007/BF00265206 Seidler RD, 2002, MOTOR CONTROL, V6, P19 Steele CM, 2007, DYSPHAGIA, V22, P30, DOI 10.1007/s00455-006-9037-4 Troche MS, 2010, NEUROLOGY, V75, P1912, DOI 10.1212/WNL.0b013e3181fef115 Troche MS, 2008, DYSPHAGIA, V23, P26, DOI 10.1007/s00455-007-9090-7 Vaiman M, 2008, EUR ARCH OTO-RHINO-L, V265, P663, DOI 10.1007/s00405-007-0519-2 Verin E, 2009, DYSPHAGIA, V24, P204, DOI 10.1007/s00455-008-9195-7 Wilson JA, 2008, DIS ESOPHAGUS, V21, P51, DOI 10.1111/j.1442-2050.2007.00747.x NR 40 TC 2 Z9 4 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD AUG PY 2012 VL 121 IS 8 BP 525 EP 532 PG 8 WC Otorhinolaryngology SC Otorhinolaryngology GA 991HE UT WOS:000307691300006 PM 22953659 ER PT J AU Weissbrod, PA Inglis, A Merati, AL AF Weissbrod, Philip A. Inglis, Andrew Merati, Albert L. TI The Ram Sign: Detecting Previously Undiagnosed Congenital Laryngeal Clefts in Adults SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article; Proceedings Paper CT Meeting of the American-Broncho-Esophagological-Association CY APR 27-28, 2011 CL Chicago, IL SP Amer Broncho Esophagol Assoc DE adult; aspiration; endoscopy; laryngeal cleft; pneumonia; ram sign ID LARYNGOTRACHEOESOPHAGEAL CLEFTS; MANAGEMENT; DIAGNOSIS AB Objectives: We present the clinical characteristics of a case series of adult patients with type III laryngeal clefts according to the classification of Benjamin and Inglis, in an attempt to make practitioners aware of the "ram sign," a clinical finding associated with laryngeal clefts in adults. Laryngeal clefts are uncommon defects that are nearly universally identified during infancy as a result of persistent aspiration and pneumonia. Undiagnosed laryngeal clefts in adults are extremely rare. Methods: Three type III laryngeal clefts were identified in adults (29,48, and 60 years of age) from one clinic over an 18-month period. The existing literature features only one type III cleft, to our knowledge. The 60-year-old patient represents the oldest person in the English-language literature to have a newly diagnosed laryngeal cleft. All three cases presented with various degrees of aspiration over an extended period. Results: The computed tomographic imaging and endoscopic findings from these three patients were reviewed. The videolaryngoscopic images demonstrated that the "ram sign" - an endoscopic finding associated with redundant soft tissue overlying the arytenoid cartilages that prolapses into the cleft, creating the appearance of ram's horns - was a consistent and striking feature in all three patients. Conclusions: Although rare, laryngeal clefts may represent an underdiagnosed entity in the adult population. With increased awareness, they may be identified more frequently as a treatable cause of aspiration and recurrent pneumonia. C1 [Weissbrod, Philip A.] Univ Calif San Diego Hlth Syst, Dept Surg, Div Otolaryngol Head & Neck Surg, San Diego, CA USA. [Inglis, Andrew] Seattle Childrens Hosp, Div Pediat Otolaryngol, Seattle, WA USA. [Merati, Albert L.] Univ Washington, Dept Otolaryngol, Div Laryngol, Seattle, WA 98195 USA. RP Merati, AL (reprint author), Univ Washington, Dept Otolaryngol Head & Neck Surg, 1959 NE Pacific St,Box 356515, Seattle, WA 98195 USA. CR BENJAMIN B, 1989, ANN OTO RHINOL LARYN, V98, P417 CAMERON A H, 1962, J Laryngol Otol, V76, P381, DOI 10.1017/S0022215100059508 COHEN SR, 1975, ANN OTO RHINOL LARYN, V84, P747 DUBOIS JJ, 1990, J PEDIATR SURG, V25, P855, DOI 10.1016/0022-3468(90)90191-B EVANS JNG, 1985, ANN OTO RHINOL LARYN, V94, P627 Kashima H K, 1987, Dysphagia, V2, P18, DOI 10.1007/BF02406973 Kubba H, 2005, ANN OTO RHINOL LARYN, V114, P309 Lancaster JL, 1999, J LARYNGOL OTOL, V113, P469 MONTGOMERY WW, 1976, ANN OTO RHINOL LARYN, V85, P491 Moungthong G, 1997, ANN OTO RHINOL LARYN, V106, P1002 Pettersson G., 1969, Z KINDERCHIR, V7, P43 Rahbar R, 2006, ARCH OTOLARYNGOL, V132, P1335, DOI 10.1001/archotol.132.12.1335 ROTH B, 1983, EUR J PEDIATR, V140, P41, DOI 10.1007/BF00661903 Thornton M, 2001, J LARYNGOL OTOL, V115, P821 NR 14 TC 0 Z9 0 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD AUG PY 2012 VL 121 IS 8 BP 533 EP 538 PG 6 WC Otorhinolaryngology SC Otorhinolaryngology GA 991HE UT WOS:000307691300007 PM 22953660 ER PT J AU Lowell, SY Kelley, RT Awan, SN Colton, RH Chan, NH AF Lowell, Soren Y. Kelley, Richard T. Awan, Shaheen N. Colton, Raymond H. Chan, Natalie H. TI Spectral- and Cepstral-Based Acoustic Features of Dysphonic, Strained Voice Quality SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE acoustic measures; cepstral measures; dysphonia; spectral measures; strain; voice disorder ID PHONATION THRESHOLD PRESSURE; VOCALLY FATIGUING TASK; CONTINUOUS SPEECH; FUNDAMENTAL-FREQUENCY; FUNCTIONAL DYSPHONIA; SYSTEMIC HYDRATION; SEVERITY; PARAMETERS; DISORDERS; INDEX AB Objectives: We sought to determine whether spectral- and cepstral-based acoustic measures were effective in distinguishing dysphonic-strained voice quality from normal voice quality and whether these measures were related to auditory-perceptual ratings of strain severity. Methods: Voice samples from 23 speakers with dysphonia characterized predominantly by strained voice quality and 23 speakers with normal voice were acoustically analyzed. Measures related to the prominence of the cepstral peak and the ratio of low- to high-frequency spectral energies, as well as the variation of each, were computed from continuous speech and a sustained vowel. Correlations to perceptually rated strain severity were determined. Results: Measures related to the cepstrum were the strongest discriminators between dysphonic-strained voice and normal voice. Variation in the ratio of low- to high-frequency spectral energies also significantly differentiated the two speaker groups. All measures were significantly correlated with perceptually rated strain severity, including an acoustic severity index that incorporated both cepstral- and spectral-based measures. Conclusions: Cepstral- and spectral-based measures that have been previously studied in dysphonia characterized by breathiness and roughness are effective in distinguishing strained dysphonia from normal voice quality. The utility of these acoustic measures is supported by their moderate-to-high relationship with perceptually rated strain severity. C1 [Lowell, Soren Y.; Colton, Raymond H.; Chan, Natalie H.] Syracuse Univ, Dept Commun Sci & Disorders, Syracuse, NY 13210 USA. [Kelley, Richard T.] Upstate Med Univ, Dept Otolaryngol & Commun Sci, Syracuse, NY USA. [Awan, Shaheen N.] Bloomsburg Univ Penn, Dept Speech Pathol & Audiol, Bloomsburg, PA 17815 USA. RP Lowell, SY (reprint author), Syracuse Univ, Dept Commun Sci & Disorders, 805 S Crouse Ave,Hoople Bldg, Syracuse, NY 13210 USA. CR ASKENFELT AG, 1986, J SPEECH HEAR RES, V29, P50 Awan SN, 2009, J SPEECH LANG HEAR R, V52, P482, DOI 10.1044/1092-4388(2009/08-0034) Awan SN, 2010, CLIN LINGUIST PHONET, V24, P742, DOI 10.3109/02699206.2010.492446 Awan SN, 2006, CLIN LINGUIST PHONET, V20, P35, DOI 10.1080/02699200400008353 Awan SN, 2005, J VOICE, V19, P268, DOI 10.1016/j.jvoice.2004.03.005 Awan SN, 2009, CLIN LINGUIST PHONET, V23, P825, DOI 10.3109/02699200903242988 Boone Daniel R., 2005, VOICE VOICE THERAPY Case J. L., 2002, CLIN MANAGEMENT VOIC Chang A, 2004, J VOICE, V18, P454, DOI 10.1016/j.jvoice.2004.01.004 DEKROM G, 1994, J SPEECH HEAR RES, V37, P985 Eadie TL, 2005, J VOICE, V19, P1, DOI 10.1016/j.jvoice.2004.02.002 Eadie TL, 2006, J VOICE, V20, P527, DOI 10.1016/j.jvoice.2005.08.007 Grillo EU, 2008, J VOICE, V22, P546, DOI 10.1016/j.jvoice.2006.12.008 Halberstam B, 2004, ORL J OTO-RHINO-LARY, V66, P70, DOI 10.1159/000077798 Hartl DM, 2003, EUR ARCH OTO-RHINO-L, V260, P175, DOI 10.1007/s00405-002-0542-2 Heman-Ackah YD, 2002, J VOICE, V16, P20, DOI 10.1016/S0892-1997(02)00067-X Hillenbrand J, 1996, J SPEECH HEAR RES, V39, P311 Hirano M, 1981, CLIN EXAMINATION VOI Kempster GB, 2009, AM J SPEECH-LANG PAT, V18, P124, DOI 10.1044/1058-0360(2008/08-0017) Lowell SY, 2011, J VOICE, V25, pE223, DOI 10.1016/j.jvoice.2010.06.007 Lowell SY, 2008, J SPEECH LANG HEAR R, V51, P333, DOI 10.1044/1092-4388(2008/025) Maryn Y, 2010, J VOICE, V24, P540, DOI 10.1016/j.jvoice.2008.12.014 NETSELL R, 1984, AM J OTOLARYNG, V5, P397, DOI 10.1016/S0196-0709(84)80055-1 PETERSON KL, 1994, ANN OTO RHINOL LARYN, V103, P335 Pinczower R, 2005, J VOICE, V19, P440, DOI 10.1016/j.jvoice.2004.07.002 Roy N, 2005, J VOICE, V19, P582, DOI 10.1016/j.jvoice.2004.08.005 Solomon NP, 2003, J VOICE, V17, P31, DOI 10.1016/S0892-1997(03)00029-8 Solomon NP, 2000, J VOICE, V14, P341 Stepp CE, 2010, J SPEECH LANG HEAR R, V53, P1220, DOI 10.1044/1092-4388(2010/09-0234) TITZE IR, 1992, J ACOUST SOC AM, V91, P2926, DOI 10.1121/1.402928 Verdolini K, 2002, J SPEECH LANG HEAR R, V45, P268, DOI 10.1044/1092-4388(2002/021) Watts CR, 2011, J SPEECH LANG HEAR R, V54, P1525, DOI 10.1044/1092-4388(2011/10-0209) NR 32 TC 6 Z9 6 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD AUG PY 2012 VL 121 IS 8 BP 539 EP 548 PG 10 WC Otorhinolaryngology SC Otorhinolaryngology GA 991HE UT WOS:000307691300008 PM 22953661 ER PT J AU Zeitler, DM Herman, BS Snapp, HA Telischi, FF Angeli, SI AF Zeitler, Daniel M. Herman, Bjorn S. Snapp, Hillary A. Telischi, Fred F. Angeli, Simon I. TI Ethnic Disparity in Skin Complications Following Bone-Anchored Hearing Aid Implantation SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE bone-anchored hearing aid; ethnicity; hearing loss; immunosuppression; keloid; postoperative complication ID INNER-EAR DEAFNESS; BAHA SURGERY; DERMATOME; KELOIDS AB Objectives: Sound processor loading after implantation of a bone-anchored hearing aid is often delayed by skin-site complications. This study examined the frequency of skin-site complications in various ethnic groups and determined factors that may lead to higher rates of skin-site complications resulting in delayed processor loading. Methods: Adult, English-speaking patients who underwent implantation of a bone-anchored hearing aid between 2007 and 2010 were reviewed. Demographic data including ethnicity, tobacco use, diabetes mellitus, immunosuppression, and long-term steroid use were determined. Major and minor skin-site complications and the time to processor loading were recorded. Results: The mean time to processor loading was 9.5 weeks, and the mean follow-up time was 23 months. There were no cases of osseointegration failure. African American patients had a significantly higher rate of major skin-site complications (p < 0.005) and a longer time to processor loading (mean, 17.6 weeks; p < 0.05) than the other ethnic groups. There was no significant difference in minor skin complication rates. There was no correlation between diabetes mellitus, long-term immunosuppression, or tobacco use and skin-site complications. Conclusions: Skin complications can delay processor loading following implantation of a bone-anchored hearing aid. There is a higher rate of major skin-site complications in African American patients, and these often delay processor loading. The risk of skin-site complications is not correlated with smoking, diabetes mellitus, or immunosuppression. An increased risk of skin-site complications is an important consideration for preoperative counseling. C1 [Zeitler, Daniel M.; Herman, Bjorn S.; Snapp, Hillary A.; Telischi, Fred F.; Angeli, Simon I.] Univ Miami, Miller Sch Med, Dept Otolaryngol, Ear Inst, Miami, FL 33136 USA. RP Zeitler, DM (reprint author), 401 E Hampden Pl,Suite 240, Englewood, CO 80110 USA. CR ALHADY SMA, 1969, PLAST RECONSTR SURG, V44, P564, DOI 10.1097/00006534-196912000-00006 Burd A, 2005, PLAST RECONSTR SURG, V116, p150E, DOI 10.1097/01.prs.0000191977.51206.43 Davis PA, 1999, DIGEST SURG, V16, P60, DOI 10.1159/000018695 de Wolf MJF, 2008, OTOL NEUROTOL, V29, P1100, DOI 10.1097/MAO.0b013e31818599b8 Dutt SN, 2002, J LARYNGOL OTOL, V116, P7 FAHEY TJ, 1991, J SURG RES, V50, P308, DOI 10.1016/0022-4804(91)90196-S Gluth MB, 2010, OTOL NEUROTOL, V31, P1427, DOI 10.1097/MAO.0b013e3181f0c53e Hobson JC, 2010, J LARYNGOL OTOL, V124, P132, DOI 10.1017/S0022215109991708 Hol MKS, 2005, OTOL NEUROTOL, V26, P999, DOI 10.1097/01.mao.0000185065.04834.95 Hol MKS, 2004, AUDIOL NEURO-OTOL, V9, P274, DOI 10.1159/000080227 Hol MKS, 2006, OTOL NEUROTOL, V27, P1300 Hol MKS, 2004, ARCH OTOLARYNGOL, V130, P394, DOI 10.1001/archotol.130.4.394 HOLGERS KM, 1988, AM J OTOL, V9, P56 House JW, 2007, OTOL NEUROTOL, V28, P213, DOI 10.1097/MAO.0b013e31802c74c4 KETCHUM LD, 1974, PLAST RECONSTR SURG, V53, P140, DOI 10.1097/00006534-197402000-00004 Lustig LR, 2001, OTOL NEUROTOL, V22, P328, DOI 10.1097/00129492-200105000-00010 Manassa EH, 2003, PLAST RECONSTR SURG, V111, P2082, DOI 10.1097/01.PRS.0000057144.62727.C8 McDermott AL, 2009, OTOL NEUROTOL, V30, P178, DOI 10.1097/MAO.0b013e31818b6271 POLLACK SV, 1982, INT J DERMATOL, V21, P489, DOI 10.1111/j.1365-4362.1982.tb01189.x Shirazi MA, 2006, OTOLARYNG HEAD NECK, V134, P236, DOI 10.1016/j.otohns.2005.10.027 Snapp HA, 2010, J AM ACAD AUDIOL, V21, P654, DOI 10.3766/jaaa.21.10.5 Stalfors J, 2008, OTOL NEUROTOL, V29, P1109, DOI 10.1097/MAO.0b013e318185fabc Tjellström A, 1981, Am J Otol, V2, P304 van de Berg R, 2010, OTOL NEUROTOL, V31, P129, DOI 10.1097/MAO.0b013e3181c29fec Van Rompaey V, 2011, EUR ARCH OTO-RHINO-L, V268, P373, DOI 10.1007/s00405-010-1366-0 Wazen JJ, 2007, LARYNGOSCOPE, V117, P794, DOI 10.1097/01.mlg.0000231281.76358.cc Wilkinson EP, 2009, OTOLARYNG HEAD NECK, V140, P573, DOI 10.1016/j.otohns.2008.12.008 Zeitler DM, 2011, OTOLARYNG HEAD NECK, V144, P402, DOI 10.1177/0194599810391398 NR 28 TC 5 Z9 5 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD AUG PY 2012 VL 121 IS 8 BP 549 EP 554 PG 6 WC Otorhinolaryngology SC Otorhinolaryngology GA 991HE UT WOS:000307691300010 PM 22953662 ER PT J AU Wakisaka, N Kondo, S Endo, K Murono, S Yoshizaki, T AF Wakisaka, Naohiro Kondo, Satoru Endo, Kazuhira Murono, Shigeyuki Yoshizaki, Tomokazu TI Adjuvant Chemotherapy With an Oral Fluoropyrimidine, S-1, Following Reduced RADPLAT in Advanced Laryngeal Cancer SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE adjuvant chemotherapy; advanced laryngeal cancer; distant metastasis; reduced RADPLAT; S-1 ID SQUAMOUS-CELL CARCINOMA; ADVANCED HEAD; NECK-CANCER; INTRAARTERIAL CHEMOTHERAPY; RADIOTHERAPY; PRESERVATION; CISPLATIN AB Objectives: Radiation Therapy Oncology Group study 91-11 found that in resectable advanced laryngeal cancer, the lo-coregional control rate achieved with reduced intra-arterial cisplatin and concurrent radiotherapy (RADPLAT) was comparable to that of a concurrent chemoradiotherapy arm, with reduced toxicities. However, distant metastases were more frequent. Our study retrospectively evaluated the efficacy and feasibility of adjuvant chemotherapy with S-1, an oral fluoropyrimidine, for distant metastases following reduced RADPLAT. Methods: We analyzed 61 patients who were treated with reduced RADPLAT and achieved a complete response at the primary site. After the use of reduced RADPLAT, 24 patients were administered S-1 for 2 weeks followed by 1 week of rest, and the cycle was repeated for 6 months (S-1+ group). Thirty-seven patients were not administered S-1 (S-1 group). Results: The hazard ratio for distant metastases in the S-1+ group was 0.114 (95% confidence interval, 0.015 to 0.881; p = 0.0374). There was a significant difference in disease-free survival in favor of the S-1+ group (p = 0.0455). Nineteen patients (79.2%) in the S-1+ group received S-1 according to the planned schedule and dose. Grade 3 toxicities were observed in 2 patients (8.3%), but there was no grade 4 event. Conclusions: In resectable advanced laryngeal cancer, S-1 adjuvant chemotherapy is an effective and feasible treatment option to control distant metastases following reduced RADPLAT. C1 [Wakisaka, Naohiro; Kondo, Satoru; Endo, Kazuhira; Murono, Shigeyuki; Yoshizaki, Tomokazu] Kanazawa Univ, Grad Sch Med Sci, Div Otolaryngol Head & Neck Surg, Kanazawa, Ishikawa 9208640, Japan. RP Yoshizaki, T (reprint author), Kanazawa Univ, Grad Sch Med Sci, Div Otolaryngol Head & Neck Surg, Takara Machi 13-1, Kanazawa, Ishikawa 9208640, Japan. FU Ministry of Education, Science, Sports, Culture and Technology of Japan [C21592189] FX From the Division of Otolaryngology Head and Neck Surgery, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan. This work was supported by a scientific research grant from the Ministry of Education, Science, Sports, Culture and Technology of Japan (C21592189). CR [Anonymous], 1987, CANCER, V60, P301 Diasio RB, 1999, ONCOLOGY-NY, V13, P17 Doweck I, 2002, LARYNGOSCOPE, V112, P1742, DOI 10.1097/00005537-200210000-00006 ERVIN TJ, 1987, J CLIN ONCOL, V5, P10 Forastiere AA, 2003, NEW ENGL J MED, V349, P2091, DOI 10.1056/NEJMoa031317 Inuyama Y, 2001, Gan To Kagaku Ryoho, V28, P1381 JACOBS C, 1990, J CLIN ONCOL, V8, P838 Johnson JT, 1996, CANCER, V77, P181, DOI 10.1002/(SICI)1097-0142(19960101)77:1<181::AID-CNCR29>3.3.CO;2-4 LARAMORE GE, 1992, INT J RADIAT ONCOL, V23, P705 Mendenhall WM, 1997, J CLIN ONCOL, V15, P2394 Pfister DG, 2006, J CLIN ONCOL, V24, P3693, DOI 10.1200/JCD.2006.07.4559 Robbins KT, 2005, J CLIN ONCOL, V23, P1447, DOI 10.1200/JCO.2005.03.168 Robbins KT, 2000, HEAD NECK-J SCI SPEC, V22, P687, DOI 10.1002/1097-0347(200010)22:7<687::AID-HED8>3.0.CO;2-W ROBBINS KT, 1994, J CLIN ONCOL, V12, P2113 Shirasaka T, 1996, ANTI-CANCER DRUG, V7, P548, DOI 10.1097/00001813-199607000-00010 Tsukuda M, 2005, BRIT J CANCER, V93, P884, DOI 10.1038/sj.bjc.6602804 Tsukuda M, 1994, Gan To Kagaku Ryoho, V21, P1169 Yonekura K, 1999, CLIN CANCER RES, V5, P2185 Yoshizaki T, 2007, ANN OTO RHINOL LARYN, V116, P754 Yoshizaki T, 2009, ANN OTO RHINOL LARYN, V118, P172 NR 20 TC 0 Z9 0 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD AUG PY 2012 VL 121 IS 8 BP 555 EP 562 PG 8 WC Otorhinolaryngology SC Otorhinolaryngology GA 991HE UT WOS:000307691300011 PM 22953663 ER PT J AU Brunworth, JD Garg, R Mahboubi, H Johnson, B Djalilian, HR AF Brunworth, Joseph D. Garg, Rohit Mahboubi, Hossein Johnson, Brandon Djalilian, Hamid R. TI Detecting Nasopharyngeal Reflux: A Novel pH Probe Technique SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE 24-hour pH monitoring; gastroesophageal reflux disease; GERD; nasopharynx; pH probe; reflux ID GASTROESOPHAGEAL-REFLUX; EUSTACHIAN-TUBE; NORMAL VALUES; EXPOSURE; DISEASE AB Objectives: We sought to ascertain the normal pH values in the aerosolized environment of the nasopharynx in healthy subjects and utilize a novel pH probe that allows measuring acidity in a nonliquid environment. Methods: Between November 2009 and February 2011, healthy volunteers without a history of reflux or eustachian tube dysfunction were enrolled in the prospective study. A total of 20 subjects had a Dx-pH Measurement System Probe (Respiratory Technology Corp) placed near the torus tubarius. The pH probe records the pH throughout the 24-hour study. A pH below 5.5 while the subject was upright or below 5.0 while the subject was supine was used as a criterion to determine a reflux event. Recording was stopped during meals. Results: For normal individuals with no history of reflux or eustachian tube dysfunction, the pH values obtained from the nasopharynx ranged from 6.10 to 7.92. The average pH was 7.03 (SD, 0.67). Eight subjects (40%) had at least 1 reflux event during the 24-hour pH study. Conclusions: By utilizing a novel self-condensing pH probe, we were able to perform a 24-hour pH study in the nasopharynx of 20 healthy individuals. In our study, the average pH for individuals without symptomatic reflux or eustachian tube dysfunction was 7.03. Interestingly, 8 control subjects had at least 1 episode of pH below 5.5 while awake or below 5.0 while asleep, which was considered to be a reflux event in our study. C1 [Brunworth, Joseph D.; Garg, Rohit; Mahboubi, Hossein; Johnson, Brandon; Djalilian, Hamid R.] Univ Calif Irvine, Dept Otolaryngol, Orange, CA 92868 USA. RP Brunworth, JD (reprint author), Univ Calif Irvine, Dept Otolaryngol, 101 City Dr S,Bldg 56,Suite 500, Orange, CA 92868 USA. CR Ayazi S, 2009, J GASTROINTEST SURG, V13, P1422, DOI 10.1007/s11605-009-0915-6 Belafsky PC, 2001, LARYNGOSCOPE, V111, P1313, DOI 10.1097/00005537-200108000-00001 CLSI, 2008, C28A3 CLSI, V3rd DEMEESTER TR, 1976, ANN SURG, V184, P459, DOI 10.1097/00000658-197610000-00009 Heavner SB, 2001, OTOLARYNG HEAD NECK, V125, P123, DOI 10.1067/mhn.2001.116448 Hoppo T, 2012, J GASTROINTEST SURG, V16, P16, DOI 10.1007/s11605-011-1741-1 JOHNSON LF, 1974, AM J GASTROENTEROL, V62, P325 Karkos PD, 2004, INT J PEDIATR OTORHI, V68, P1489, DOI 10.1016/j.ijporl.2004.07.019 Maldonado A, 2003, LARYNGOSCOPE, V113, P349, DOI 10.1097/00005537-200302000-00027 SOLBERG HE, 1987, J CLIN CHEM CLIN BIO, V25, P645 Sun G, 2009, LARYNGOSCOPE, V119, P1693 White DR, 2002, LARYNGOSCOPE, V112, P955, DOI 10.1097/00005537-200206000-00004 WIENER GJ, 1989, AM J GASTROENTEROL, V84, P1503 Yazici ZM, 2008, LARYNGOSCOPE, V118, P849, DOI 10.1097/MLG.0b013e318164d0c0 NR 14 TC 4 Z9 4 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD JUL PY 2012 VL 121 IS 7 BP 427 EP 430 PG 4 WC Otorhinolaryngology SC Otorhinolaryngology GA 973XT UT WOS:000306394500001 PM 22844860 ER PT J AU Koufman, JA Johnston, N AF Koufman, Jamie A. Johnston, Nikki TI Potential Benefits of pH 8.8 Alkaline Drinking Water as an Adjunct in the Treatment of Reflux Disease SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE acid reflux; alkaline water; Barrett's esophagus; gastroesophageal reflux disease; laryngopharyngeal reflux; pepsin ID LARYNGEAL EPITHELIAL DEFENSES; ANHYDRASE ISOENZYME-III; LARYNGOPHARYNGEAL REFLUX; GASTROESOPHAGEAL-REFLUX; ESOPHAGEAL ADENOCARCINOMA; CELL BIOLOGY; PEPSIN; ACID; SYMPTOMS; HEALTH AB Objectives: At the cellular level, tissue-bound pepsin is fundamental to the pathophysiologic mechanism of reflux disease, and although the thresholds for laryngeal damage in laryngopharyngeal reflux and for esophageal damage in gastroesophageal reflux disease differ, both forms of damage are due to pepsin, which requires acid for its activation. In addition, human pepsin remains stable at pH 7.4 and may be reactivated by hydrogen ions from any source. Thus, most tap and bottled waters (typically pH 6.7 to 7.4) would not be expected to affect pepsin stability. The purposes of these in vitro studies were to investigate whether artesian well water containing natural bicarbonate (pH 8.8) might irreversibly denature (inactivate) human pepsin, and to establish its potential acid-buffering capacity. Methods: Laboratory studies were performed to determine whether human pepsin was inactivated by pH 8.8 alkaline water. In addition, the buffering capacity of the alkaline water was measured and compared to that of the two most popular commercially available bottled waters. Results: The pH 8.8 alkaline water irreversibly inactivated human pepsin (in vitro), and its hydrochloric acid buffering capacity far exceeded that of the conventional-pH waters. Conclusions: Unlike conventional drinking water, pH 8.8 alkaline water instantly denatures pepsin, rendering it permanently inactive. In addition, it has good acid-buffering capacity. Thus, the consumption of alkaline water may have therapeutic benefits for patients with reflux disease. C1 [Koufman, Jamie A.] Voice Inst New York, New York, NY 10019 USA. [Koufman, Jamie A.] New York Med Coll, New York Eye & Ear Infirm, Dept Otolaryngol, New York, NY USA. [Johnston, Nikki] Med Coll Wisconsin, Dept Otolaryngol, Milwaukee, WI 53226 USA. RP Koufman, JA (reprint author), Voice Inst New York, 200 W 57th St,Suite 1203, New York, NY 10019 USA. CR Altman KW, 2005, LARYNGOSCOPE, V115, P1145, DOI 10.1097/01.MLG.0000165464.75164.ES [Anonymous], 2009, GEN REC SAF FOOD ADD Axford SE, 2001, ANN OTO RHINOL LARYN, V110, P1099 Conio M, 2003, AM J GASTROENTEROL, V98, P1931, DOI 10.1016/S0002-9270(03)00629-4 El-Serag H, 2010, ALIMENT PHARM THER, V32, P720, DOI 10.1111/j.1365-2036.2010.04406.x El-Serag HB, 2007, CLIN GASTROENTEROL H, V5, P17, DOI 10.1016/j.cgh.2006.09.016 Gill GA, 2005, ANN OTO RHINOL LARYN, V114, P913 GOLDBERG HI, 1969, GASTROENTEROLOGY, V56, P223 Halum SL, 2005, LARYNGOSCOPE, V115, P1042, DOI 10.1097/01.MLG.0000162656.05715.57 JOHNSON LF, 1986, J CLIN GASTROENTEROL, V8, P26, DOI 10.1097/00004836-198606001-00006 Johnston N, 2007, LARYNGOSCOPE, V117, P1036, DOI 10.1097/M1LG.0b013e31804154c3 Johnston N, 2006, ANN OTO RHINOL LARYN, V115, P47 Johnston N, 2012, LARYNGOSCOPE, V122, P1317, DOI 10.1002/lary.23307 Johnston N, 2004, LARYNGOSCOPE, V114, P2129, DOI 10.1097/01.mlg.0000149445.07146.03 Johnston N, 2003, ANN OTO RHINOL LARYN, V112, P481 Knight J, 2005, LARYNGOSCOPE, V115, P1473, DOI 10.1097/01.mlg.0000172043.51871.d9 Koufman J, 2010, DROPPING ACID REFLUX KOUFMAN JA, 1991, LARYNGOSCOPE, V101, P1 Koufman JA, 2011, ANN OTO RHINOL LARYN, V120, P281 Koufman JA, 2009, CLASSICS VOICE LARYN, P179 LILLEMOE KD, 1982, SURGERY, V92, P276 LUND O, 1989, BRIT J SURG, V76, P1301, DOI 10.1002/bjs.1800761227 PIPER DW, 1965, GUT, V6, P506, DOI 10.1136/gut.6.5.506 Pohl H, 2005, J NATL CANCER I, V97, P142, DOI 10.1093/jnci/dji024 Reavis KM, 2004, ANN SURG, V239, P849, DOI 10.1097/01.sla.0000128303.05898.ee Samuels TL, 2010, ANN OTO RHINOL LARYN, V119, P203 NR 26 TC 0 Z9 1 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD JUL PY 2012 VL 121 IS 7 BP 431 EP 434 PG 4 WC Otorhinolaryngology SC Otorhinolaryngology GA 973XT UT WOS:000306394500002 PM 22844861 ER PT J AU Tan, M Prufer, N Chinosornvatana, N Park, C Woo, P AF Tan, Melin Prufer, Neil Chinosornvatana, Nina Park, Chan Woo, Peak TI Application of Natural Orifice Transluminal Endoscopic Surgery (NOTES) Instrumentation to the Endolarynx SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article; Proceedings Paper CT Meeting of the American-Broncho-Esophagological-Association CY APR 27-28, 2011 CL Chicago, IL SP Amer Broncho Esophagol Assoc DE endolarynx; endoscopic laryngeal surgery; laryngoscopy; NOTES ID TRANSORAL ROBOTIC SURGERY; SUPRAGLOTTIC LARYNGECTOMY AB Objectives: RealHand instruments are high-dexterity instruments that have been designed for natural orifice transluminal endoscopic surgery applications. They provide dexterity by offering a full range of motion to endoscopic instruments. We hypothesize that RealHand instruments will resolve some of the limitations encountered in traditional endolaryngeal surgery. They have the potential to do so in the following ways: 1) they negate the limitation of mobility of traditional laryngoscopy instrumentation, which is rigid and fixed; 2) they maintain the ability of direct visualization through a telescope while precluding the need for an operating microscope; 3) they provide the dexterity to perform tasks that are otherwise not possible with traditional instrumentation; and 4) they provide flexibility that can be advantageous in difficult foreign body retrieval from distal airways. Methods: To test this hypothesis, we developed and optimized a cadaveric lamb larynx model for endolaryngeal microsurgery. To evaluate the feasibility of the RealHand instruments in their application to laryngeal surgery, we had 2 otolaryngology senior residents and 2 laryngology fellows-in-training perform 5 different endoscopic tasks: 1) foreign body removal; 2) arytenoidectomy; 3) microflap elevation; 4) cricopharyngeal myotomy; and 5) endoknot suture tying. Results: Experience with RealHand instruments demonstrated that although they are limited in application to phonosurgery, they have the potential for more facile tissue manipulation in the supraglottic and hypopharyngeal structures. Endoscopic suturing ability is enhanced. Conclusions: RealHand high-dexterity instrumentation allows for full range-of-motion instrumentation and, with modification, has potential for wider application in endoscopic laryngeal surgery. C1 [Tan, Melin; Prufer, Neil; Chinosornvatana, Nina; Park, Chan; Woo, Peak] Montefiore Med Ctr, Dept Otorhinolaryngol Head & Neck Surg, Bronx, NY 10467 USA. RP Tan, M (reprint author), Montefiore Med Ctr, Dept Otorhinolaryngol Head & Neck Surg, 3400 Bainbridge Ave,3rd Floor, Bronx, NY 10467 USA. CR Alipoura F, 2008, J ACOUST SOC AM, V123, P4572, DOI 10.1121/1.2908289 Genden EM, 2009, HEAD NECK-J SCI SPEC, V31, P283, DOI 10.1002/hed.20972 Giday SA, 2006, MINIM INVASIV THER, V15, P373, DOI 10.1080/13645700601038010 JAKO GJ, 1970, ARCHIV OTOLARYNGOL, V91, P196 Kalloo AN, 2004, GASTROINTEST ENDOSC, V60, P114, DOI 10.1016/S0016-5107(04)01309-4 Kawaida M, 2002, J VOICE, V16, P105, DOI 10.1016/S0892-1997(02)00079-6 Solares CA, 2007, LARYNGOSCOPE, V117, P817, DOI 10.1097/MLG.0b013e31803330b7 Weinstein GS, 2005, LARYNGOSCOPE, V115, P1315, DOI 10.1097/01.MLG.0000170848.76045.47 Weinstein GS, 2007, ANN OTO RHINOL LARYN, V116, P19 WOO P, 1995, J VOICE, V9, P332, DOI 10.1016/S0892-1997(05)80242-5 NR 10 TC 0 Z9 0 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD JUL PY 2012 VL 121 IS 7 BP 435 EP 441 PG 7 WC Otorhinolaryngology SC Otorhinolaryngology GA 973XT UT WOS:000306394500003 PM 22844862 ER PT J AU Whigham, AS Howell, R Choi, S Pena, M Zalzal, G Preciado, D AF Whigham, Amy S. Howell, Rebecca Choi, Sukgi Pena, Maria Zalzal, George Preciado, Diego TI Outcomes of Balloon Dilation in Pediatric Subglottic Stenosis SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article; Proceedings Paper CT Annual Meeting of the American-Academy-of-Otolaryngology-Head-and-Neck-Surgery-Foundation and OTO EXPO CY SEP 10-14, 2011 CL San Francisco, CA SP Amer Acad Otolaryngol Head & Neck Surg Fdn DE balloon dilation; pediatrics; subglottic stenosis; tracheotomy ID MANAGEMENT AB Objectives: We report outcomes of balloon dilation in the endoscopic management of pediatric subglottic stenosis (SGS) and discuss the role of balloon dilation in both primary and adjuvant therapy. Methods: We performed a retrospective review of treatment with noncompliant, high-pressure balloons for SGS in the past 2 years at a tertiary pediatric hospital. Fifty-one dilations were performed in 28 children with SGS. The children's mean age was 42 months. The mean SGS grade was 2.46. Results: Fifteen children had primary balloon dilation, and 13 had adjuvant balloon dilation. Overall, 16 children (57.1%) had successful balloon dilation. Of those who underwent primary dilation, 9 (60.0%) were able to avoid open reconstruction or tracheotomy and 6 had their symptoms temporarily improved (average, 36 days) until definitive open reconstruction. Of the patients who underwent adjuvant dilation, 7 (53.8%) were successfully decannulated. Nine of the 12 failed balloon dilations were in children who had concomitant airway disorders; in contrast, only 6 of 16 children in whom treatment was successful had concomitant airway disorders (p = 0.048). There was no statistical association between successful versus failed treatment and age (51.6 versus 27.9 months; p = 0.23), degree of stenosis (grade 2.3 versus grade 2.6; p = 0.41), presence of lung disease (33.3% versus 70%; p = 0.07), or soft versus firm stenosis (60.0% versus 53.1%; p = 0.71). Conclusions: Balloon dilation plays an important role in the primary and adjuvant management of pediatric SGS. The presence of concomitant airway lesions is significantly associated with failure of balloon dilation treatment. Meticulous surveillance of the dilated airway is necessary, given this failure rate. C1 [Whigham, Amy S.; Howell, Rebecca; Choi, Sukgi; Pena, Maria; Zalzal, George; Preciado, Diego] George Washington Univ, Sch Med, Childrens Natl Med Ctr, Div Otolaryngol, Washington, DC 20010 USA. RP Preciado, D (reprint author), George Washington Univ, Sch Med, Childrens Natl Med Ctr, Div Otolaryngol, 111 Michigan Ave NW, Washington, DC 20010 USA. CR Bent JP, 2010, ANN OTO RHINOL LARYN, V119, P619 Choi SS, 2000, OTOLARYNG HEAD NECK, V122, P61, DOI 10.1016/S0194-5998(00)70145-8 Durden F, 2007, ARCH OTOLARYNGOL, V133, P772, DOI 10.1001/archotol.133.8.772 Edmondson NE, 2010, INT J PEDIATR OTORHI, V74, P1078, DOI 10.1016/j.ijporl.2010.05.027 Lando T, 2008, OTOLARYNG CLIN N AM, V41, P935, DOI 10.1016/j.otc.2008.04.007 Lee KH, 2008, ANN OTO RHINOL LARYN, V117, P81 MYER CM, 1994, ANN OTO RHINOL LARYN, V103, P319 Rutter MJ, 2008, CURR OPIN OTOLARYNGO, V16, P525, DOI 10.1097/MOO.0b013e3283184479 NR 8 TC 12 Z9 13 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD JUL PY 2012 VL 121 IS 7 BP 442 EP 448 PG 7 WC Otorhinolaryngology SC Otorhinolaryngology GA 973XT UT WOS:000306394500004 PM 22844863 ER PT J AU Holmes, SRM Gudridge, TA Gaudiani, JL Mehler, PS AF Holmes, Samantha R. M. Gudridge, Tricia A. Gaudiani, Jennifer L. Mehler, Philip S. TI Dysphagia in Severe Anorexia Nervosa and Potential Therapeutic Intervention: A Case Series SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE anorexia nervosa; aspiration; deglutition disorder; dysphagia; neuromuscular electrical stimulation ID NEUROMUSCULAR ELECTRICAL-STIMULATION; STROKE PATIENTS; ASPIRATION; REHABILITATION; DISORDERS AB Objectives: In severe anorexia nervosa, there are a litany of medical complications that affect virtually every body system, and severe weakness is a typical characteristic. To our knowledge, aspiration risk, dysphagia recognition, and dysphagia management and intervention have not been well described in the literature in regard to severe anorexia nervosa. The purpose of this case series is to increase awareness among clinicians of possible oropharyngeal dysphagia symptoms that may present in patients with severe anorexia nervosa. Methods: We describe the cases of 3 patients with severe anorexia nervosa who presented with symptoms of dysphagia. The speech-language pathology team administered dysphagia therapy to the 3 patients utilizing neuromuscular electrical stimulation (NMES) in conjunction with swallowing therapy tasks that included strengthening exercises and compensatory strategies. Results: After the course of dysphagia treatment intervention, the 3 patients were able to tolerate an oral diet with improved swallowing function and no ongoing aspiration. Conclusions: The use of NMES in conjunction with traditional swallowing exercises in the treatment of dysphagia in patients with anorexia nervosa may reduce the need for enteral feeding and prolonged hospitalization. In regard to dysphagia intervention and management within this population and across other populations, rigorous randomized controlled studies are necessary for determining the efficacy of NMES and traditional swallowing therapy implementation. C1 [Holmes, Samantha R. M.] Denver Hlth Med Ctr, Rehabil Serv, ACUTE Ctr Eating Disorders, Denver, CO 80204 USA. RP Holmes, SRM (reprint author), Denver Hlth Med Ctr, Rehabil Serv, ACUTE Ctr Eating Disorders, 780 Delaware St,MC 0113, Denver, CO 80204 USA. CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT [Anonymous], 2001, EAT DIS FACTS EAT DI ASHA, 2008, COMM FACTS SPEC POP Blumenfeld L, 2006, OTOLARYNG HEAD NECK, V135, P754, DOI 10.1016/j.otohns.2006.04.016 Bogaardt H, 2009, ANN OTO RHINOL LARYN, V118, P241 Bulow M, 2008, DYSPHAGIA, V23, P302, DOI 10.1007/s00455-007-9145-9 Burkhead LM, 2009, PERSPECTIVES SWALLOW, V18, P43 Carnaby-Mann GD, 2007, ARCH OTOLARYNGOL, V133, P564, DOI 10.1001/archotol.133.6.564 Cherney LR, 1994, CLIN MANAGEMENT DYSP Ciyiltepe M, 2006, TURKISH J PEDIATR, V48, P80 Clark H, 2009, AM J SPEECH-LANG PAT, V18, P361, DOI 10.1044/1058-0360(2009/08-0088) Domenech E, 1999, MED CLIN N AM, V83, P97, DOI 10.1016/S0025-7125(05)70090-0 Freed M, 2003, VITALSTIM CERTIFICAT Garon BR, 1997, J NEUROL REHABIL, V11, P139 Godbole M, 2010, INT J EAT DISORDER, V43, P480, DOI 10.1002/eat.20702 Groher ME, 1997, DYSPHAGIA DIAGNOSIS Hinchey JA, 2005, STROKE, V36, P1972, DOI 10.1161/01.STR.0000177529.8686.8d HOLAS MA, 1994, ARCH NEUROL-CHICAGO, V51, P1051 Howden CW, 2004, AM J MED, V117, p44S, DOI 10.1016/j.amjmed.2004.07.017 Hudson HM, 2000, DYSPHAGIA, V15, P31 Hughes PJ, 2000, HEAD NECK-J SCI SPEC, V22, P393, DOI 10.1002/1097-0347(200007)22:4<393::AID-HED13>3.0.CO;2-2 Lovell SJ, 2005, HEAD NECK-J SCI SPEC, V27, P864, DOI 10.1002/hed.20250 Mehler P. S., 2010, EATING DISORDERS GUI Palmer JB, 2000, AM FAM PHYSICIAN, V61, P2453 Permsirivanich Wutichai, 2009, Journal of the Medical Association of Thailand, V92, P259 Robbins J, 2008, J SPEECH LANG HEAR R, V51, pS276, DOI 10.1044/1092-4388(2008/021) Rosenbek JC, 1996, DYSPHAGIA, V11, P93, DOI 10.1007/BF00417897 Ryu JS, 2009, ORAL ONCOL, V45, P665, DOI 10.1016/j.oraloncology.2008.10.005 Shaw GY, 2007, ANN OTO RHINOL LARYN, V116, P36 SULLIVAN PF, 1995, AM J PSYCHIAT, V152, P1073 VELDEE M S, 1992, Dysphagia, V7, P86, DOI 10.1007/BF02493439 NR 31 TC 2 Z9 2 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD JUL PY 2012 VL 121 IS 7 BP 449 EP 456 PG 8 WC Otorhinolaryngology SC Otorhinolaryngology GA 973XT UT WOS:000306394500005 PM 22844864 ER PT J AU Deng, YF Zhou, DN Ye, CS Zeng, L Yin, P AF Deng, Yan Fei Zhou, Dong Ni Ye, Chun Sheng Zeng, Liang Yin, Ping TI Aberrant Expression Levels of MTA1 and RECK in Nasopharyngeal Carcinoma: Association With Metastasis, Recurrence, and Prognosis SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE in situ hybridization; MTA1; nasopharyngeal carcinoma; RECK ID SQUAMOUS-CELL CARCINOMAS; SUPPRESSOR RECK; DOWN-REGULATION; LUNG-CANCER; INVASION; PROTEIN; GENE; ADENOCARCINOMA; DEACETYLATION; INVOLVEMENT AB Objectives: We investigated the expression and clinical value of MTA1 and RECK genes in patients with nasopharyngeal carcinoma (NPC). Methods: We examined MTA1 and RECK expression in nasopharyngeal tissue from patients with chronic nasopharyngitis, lymph nodes with metastasis of NPC, and primary NPC tumor tissue by means of in situ hybridization and analyzed their correlation with the clinicopathologic features of NPC. Results: The positive expression of MTA1 in the NPC tissues and metastatic lymph nodes was significantly higher than that in the chronic nasopharyngitis tissues (p < 0.05). The positive expression of RECK in the NPC tissues and metastatic lymph nodes was significantly lower than that in the chronic nasopharyngitis tissues (p < 0.05). The RECK expression level was inversely correlated with the MTA1 expression level in the NPC tissues (p < 0.05). The increased MTA1 and decreased RECK expressions in the NPC tissues had no association with gender, age, T-stage, or clinical stage (p > 0.05). However, they had a positive correlation with cervical lymph node metastasis, tumor recurrence, and 5-year overall survival rate of the patients with NPC (p < 0.05). Moreover, multivariate analysis showed that MTA1 and RECK expressions were independent prognostic factors for survival (p < 0.05). Conclusions: The conversely abnormal expression levels of MTA1 and RECK may be collectively involved in progression of malignancies and may serve as molecular predictors for metastasis, recurrence, and prognosis of NPC. C1 [Deng, Yan Fei] Xiamen Univ, Zhongshan Hosp, Dept Otolaryngol Head & Neck Surg, Xiamen, Peoples R China. [Zhou, Dong Ni; Yin, Ping] Xiamen Univ, Zhongshan Hosp, Dept Pathol, Xiamen, Peoples R China. [Deng, Yan Fei; Ye, Chun Sheng] Fujian Med Univ, Zhongshan Hosp, Dept Otolaryngol Head & Neck Surg, Xiamen, Peoples R China. [Zeng, Liang] Tumor Hosp Hunan Prov, Dept Pathol, Changsha, Peoples R China. RP Deng, YF (reprint author), Xiamen Univ, Zhongshan Hosp, Dept Otolaryngol Head & Neck Surg, 209 Rubin S Rd, Fujian 361004, Peoples R China. FU Medical Innovation Program Fund of Fujian Province, China [2011-CXB-35] FX From the Departments of Otolaryngology Head and Neck Surgery (Deng) and Pathology (Zhou, Yin), Zhongshan Hospital, Xiamen University, and the Department of Otolaryngology Head and Neck Surgery, Zhongshan Hospital, Fujian Medical University (Deng, Ye), Xiamen, and the Department of Pathology, Tumor Hospital of Hunan Province, Changsha (Zeng), China. Dr Deng and Dr Zhou contributed equally to this work as co-first authors. This study was supported by the Medical Innovation Program Fund of Fujian Province, China (grant 2011-CXB-35). CR Azzoni C, 2011, VIRCHOWS ARCH, V458, P525, DOI 10.1007/s00428-011-1069-y Barnes L, 2005, WHO CLASSIFICATION T, P81 Chang HC, 2007, CANCER SCI, V98, P169, DOI 10.1111/j.1349-7006.2006.00367.x Chang HC, 2004, CELL SIGNAL, V16, P675, DOI 10.1016/j.cellsig.2003.11.001 Clark JCM, 2007, CANCER METAST REV, V26, P675, DOI 10.1007/s10555-007-9093-8 Hsu MC, 2006, J BIOL CHEM, V281, P4718, DOI 10.1074/jbc.M510937200 Jeon HW, 2010, MOL CANCER THER, V9, P1361, DOI 10.1158/1535-7163.MCT-09-0717 Kawasaki G, 2008, INT J ORAL MAX SURG, V37, P1039, DOI 10.1016/j.ijom.2008.05.020 Lee KJ, 2010, BBA-MOL CELL RES, V1803, P608, DOI 10.1016/j.bbamcr.2010.01.004 Li DQ, 2009, J BIOL CHEM, V284, P34545, DOI 10.1074/jbc.M109.056499 Li Ronghua, 2010, Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi, V24, P823 Li SL, 2007, WORLD J GASTROENTERO, V13, P6076, DOI 10.3748/wjg.13.6076 Liu LT, 2003, ONCOGENE, V22, P8263, DOI 10.1038/sj.onc.1207157 Martin MD, 2006, BREAST CANCER RES TR, V95, P7, DOI 10.1007/s10549-005-9016-8 Molli PR, 2008, ONCOGENE, V27, P1971, DOI 10.1038/sj.onc.1210839 Nicolson GL, 2003, CLIN EXP METASTAS, V20, P19, DOI 10.1023/A:1022534217769 Qian HL, 2005, CLIN EXP METASTAS, V22, P653, DOI 10.1007/s10585-006-9005-2 Rhee JS, 2002, TRENDS CELL BIOL, V12, P209, DOI 10.1016/S0962-8924(02)02280-8 Takahashi C, 1998, P NATL ACAD SCI USA, V95, P13221, DOI 10.1073/pnas.95.22.13221 Takemoto N, 2007, LUNG CANCER, V58, P376, DOI 10.1016/j.lungcan.2007.07.004 Toh Y, 2009, CLIN EXP METASTAS, V26, P215, DOI 10.1007/s10585-008-9233-8 TOH Y, 1994, J BIOL CHEM, V269, P22958 Toh Y, 2004, INT J CANCER, V110, P362, DOI 10.1002/ijc.20154 Yu Y, 2011, INTERACT CARDIOV TH, V12, P166, DOI 10.1510/icvts.2010.243741 NR 24 TC 9 Z9 10 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD JUL PY 2012 VL 121 IS 7 BP 457 EP 465 PG 9 WC Otorhinolaryngology SC Otorhinolaryngology GA 973XT UT WOS:000306394500006 PM 22844865 ER PT J AU Fundakowski, CE Anderson, J Angeli, S AF Fundakowski, Christopher E. Anderson, Joshua Angeli, Simon TI Cross-Sectional Vestibular Nerve Analysis in Vestibular Neuritis SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE magnetic resonance imaging; vestibular nerve; vestibular neuritis ID BENIGN RECURRENT VERTIGO AB Objectives: We examined the association between the size and cross-sectional area of the superior vestibular nerve as measured on constructive interference in steady-state (CISS) parasagittal magnetic resonance imaging (MRI) and the vestibular nerve function as measured by electronystagmography. Methods: The retrospective observational cohort study took place at an academic tertiary referral center. Twenty-six patients who met established clinical and electronystagmographic criteria for vestibular neuritis and who underwent parasagittal CISS MRI were identified. Two blinded investigators measured vestibular nerve height and width bilaterally at the level of the fundus of the internal auditory canal and calculated the cross-sectional nerve areas. The inter-rater reliability and agreement were analyzed. Symptom duration, age, and gender were also examined. Results: A statistically significant decrease was observed in both vestibular nerve cross-sectional area and height as compared to the contralateral vestibular nerve. A non-statistically significant trend was observed for a relative decreased cross-sectional nerve area with increased age, as well as a decrease in nerve area with an increase in symptom duration. Conclusions: Decreases in both vestibular nerve cross-sectional area and height are observed in patients with unilateral vestibular neuritis as measured on parasagittal CISS MRI. C1 [Fundakowski, Christopher E.; Anderson, Joshua; Angeli, Simon] Univ Miami, Dept Otolaryngol Head & Neck Surg, Miami, FL USA. RP Angeli, S (reprint author), 1666 NW 10th Ave,5th Floor, Miami, FL 33136 USA. CR Arbusow V, 2000, NEUROLOGY, V55, P880 Aw ST, 2001, NEUROLOGY, V57, P768 Baloh RW, 1996, OTOLARYNG HEAD NECK, V114, P586, DOI 10.1016/S0194-5998(96)70251-6 CASSELMAN JW, 1993, AM J NEURORADIOL, V14, P47 Colledge N, 2002, J NEUROL NEUROSUR PS, V72, P587, DOI 10.1136/jnnp.72.5.587 Fattori B, 2003, J LARYNGOL OTOL, V117, P467 Fetter M, 1996, BRAIN, V119, P755, DOI 10.1093/brain/119.3.755 Gianoli G, 2005, OTOL NEUROTOL, V26, P489, DOI 10.1097/01.mao.0000169787.99835.9f Glastonbury CM, 2002, AM J NEURORADIOL, V23, P635 HASUIKE K, 1995, ACTA OTO-LARYNGOL, P272 Jaryszak EM, 2009, LARYNGOSCOPE, V119, P2042, DOI 10.1002/lary.20516 Karlberg M, 2004, ARCH OTOLARYNGOL, V130, P229, DOI 10.1001/archotol.130.2.229 MORETTI G, 1980, HEADACHE, V20, P344, DOI 10.1111/j.1526-4610.1980.hed2006344.x Morita T, 2004, ACTA OTO-LARYNGOL, V551, P56 Murofushi T, 2003, NEUROLOGY, V61, P417 Oh AK, 2001, AM J MED GENET, V100, P287, DOI 10.1002/ajmg.1294 Silvoniemi P, 1988, Acta Otolaryngol Suppl, V453, P1 Strupp M, 1998, NEUROLOGY, V51, P838 Strupp M, 2004, NEW ENGL J MED, V351, P354, DOI 10.1056/NEJMoa033280 NR 19 TC 0 Z9 0 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD JUL PY 2012 VL 121 IS 7 BP 466 EP 470 PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA 973XT UT WOS:000306394500007 PM 22844866 ER PT J AU Guinand, N Boselie, F Guyot, JP Kingma, H AF Guinand, Nils Boselie, Frans Guyot, Jean-Philippe Kingma, Herman TI Quality of Life of Patients With Bilateral Vestibulopathy SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE bilateral vestibulopathy; oscillopsia; quality of life; VEMP; vestibular evoked myogenic potential; vestibular implant ID DIZZINESS HANDICAP INVENTORY; SF-36 HEALTH SURVEY; ELECTRICAL-STIMULATION; CAUSATIVE FACTORS; EYE-MOVEMENTS; FOLLOW-UP; ADAPTATION; SUPERIOR; QUESTIONNAIRE; EPIDEMIOLOGY AB Objectives: Currently, there is no evidence of an effective treatment for patients with bilateral vestibulopathy (BV). Their main complaints are oscillopsia and imbalance. Opinions about the impact of BV on their quality of life are controversial, and their handicap is not always recognized, even among otoneurologists. The aim of this study was to objectively assess the health status of BV patients in order to evaluate the need for pursuing efforts toward the development of new treatments. Methods: The Short-Form Health Survey (SF-36), the Dizziness Handicap Inventory (DHI), the Short Falls Efficacy Scale International (Short FES-I), and an oscillopsia severity questionnaire were submitted to 39 BV patients. The SF-36 scores were compared to the scores of a general Dutch population. The DHI scores were correlated to the oscillopsia severity scores. The Short FES-I scores were compared to scores in an elderly population. Residual otolithic function was correlated to all scores, and hearing to SF-36 scores. Results: Compared to the general Dutch population, the BV patients scored significantly worse on the "physical functioning," "role physical," "general health," "vitality," and "social functioning" SF-36 variables (p < 0.05). The DHI scores were strongly correlated with the oscillopsia severity scores (r = 0.75; p < 0.000001). The Short FES-I scores indicated a slight to moderate increase in the patients' fear of falling. No significant score differences were found between BV patients with residual otolithic function and patients with complete BV. There was no correlation between hearing status and SF-36 scores. Conclusions: The results correlate with our clinical impression that BV has a strong negative impact on physical and social functioning, leading to a quality-of-life deterioration. There is a clear need for a therapeutic solution. Efforts toward the development cif a vestibular implant are justified. C1 [Guinand, Nils; Boselie, Frans; Guyot, Jean-Philippe] Univ Hosp, Dept Otolaryngol Head & Neck Surg, Div Balance Disorders, Maastricht, Netherlands. [Guinand, Nils; Guyot, Jean-Philippe] Univ Hosp Geneva, Dept Otolaryngol Head & Neck Surg, Geneva, Switzerland. RP Guinand, N (reprint author), HUG, Serv ORL, CRIC, Rue Gabrielle Perret Gentil 4, CH-1211 Geneva 14, Switzerland. RI Kingma, Herman/J-7752-2013 FU European Community CLONS [225929] FX From the Division of Balance Disorders, Department of Otolaryngology Head and Neck Surgery, University Hospital Maastricht, Maastricht, the Netherlands (Guinand, Boselie, Kingma), and the Department of Otolaryngology Head and Neck Surgery, University Hospitals of Geneva, Geneva, Switzerland (Guinand, Guyot). This work was funded in part by the Seventh Framework Programme, Theme 3, Information and Communication Technologies, European Community CLONS (225929) (CLOsed-loop Neural prostheses for vestibular disorderS). CR Aaronson NK, 1998, J CLIN EPIDEMIOL, V51, P1055, DOI 10.1016/S0895-4356(98)00097-3 Brantberg K, 2007, J VESTIBUL RES-EQUIL, V17, P33 Chia EM, 2007, EAR HEARING, V28, P187, DOI 10.1097/AUD.0b013e31803126b6 Crane BT, 2008, LARYNGOSCOPE, V118, P1809, DOI 10.1097/MLG.0b013e31817f18fa Curthoys IS, 2010, CLIN NEUROPHYSIOL, V121, P132, DOI 10.1016/j.clinph.2009.09.027 Della Santina CC, 2010, J VESTIBUL RES-EQUIL, V20, P244 Feigl GC, 2009, OTOL NEUROTOL, V30, P586, DOI 10.1097/MAO.0b013e3181ab9164 Furman JM, 2010, CURR OPIN OTOLARYNGO, V18, P386, DOI 10.1097/MOO.0b013e32833ce5a6 Grabherr L, 2007, J VESTIBUL RES-EQUIL, V17, P279 Grunfeld EA, 2000, BRAIN, V123, P277, DOI 10.1093/brain/123.2.277 Guyot JP, 2011, ANN OTO RHINOL LARYN, V120, P143 Guyot JP, 2011, ANN OTO RHINOL LARYN, V120, P81 Jacobson G P, 2000, J Am Acad Audiol, V11, P76 JENKINSON C, 1993, BRIT MED J, V306, P1437 Kempen G I J M, 2007, Tijdschr Gerontol Geriatr, V38, P204 Kos MI, 2006, OTOL NEUROTOL, V27, P542, DOI 10.1097/00129492-200606000-00017 Kurre Annette, 2010, BMC Ear Nose Throat Disord, V10, P3, DOI 10.1186/1472-6815-10-3 Lewis RF, 2010, J NEUROPHYSIOL, V103, P1066, DOI 10.1152/jn.00241.2009 JACOBSON GP, 1990, ARCH OTOLARYNGOL, V116, P424 Nunnally J. C., 1978, PSYCHOMETRIC THEORY Rinne T, 1998, J NEUROL, V245, P314, DOI 10.1007/s004150050225 Tamber AL, 2009, HEALTH QUAL LIFE OUT, V7, DOI 10.1186/1477-7525-7-101 VIBERT D, 1995, ACTA OTO-LARYNGOL, V115, P611, DOI 10.3109/00016489509139375 Wall C, 2007, ANN OTO RHINOL LARYN, V116, P369 WARE JE, 1992, MED CARE, V30, P473, DOI 10.1097/00005650-199206000-00002 WEBSTER J C, 1970, Transactions of the American Academy of Ophthalmology and Oto-Laryngology, V74, P1155 Zingler VC, 2007, ANN NEUROL, V61, P524, DOI 10.1002/ana.21105 Zingler VC, 2008, J NEUROL, V255, P1332, DOI 10.1007/s00415-008-0887-6 Zingler VC, 2008, J NEUROL NEUROSUR PS, V79, P284, DOI 10.1136/jnnp.2007.122952 Zingler VC, 2009, ANN NY ACAD SCI, V1164, P505, DOI 10.1111/j.1749-6632.2009.03765.x NR 30 TC 7 Z9 7 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD JUL PY 2012 VL 121 IS 7 BP 471 EP 477 PG 7 WC Otorhinolaryngology SC Otorhinolaryngology GA 973XT UT WOS:000306394500008 PM 22844867 ER PT J AU Parker, NP Scott, AR Finkelstein, M Tibesar, RJ Lander, TA Rimell, FL Sidman, JD AF Parker, Noah P. Scott, Andrew R. Finkelstein, Marsha Tibesar, Robert J. Lander, Timothy A. Rimell, Frank L. Sidman, James D. TI Predicting Surgical Outcomes in Pediatric Cervicofacial Nontuberculous Mycobacterial Lymphadenitis SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article; Proceedings Paper CT 114th Annual Meeting of the Triological-Society CY APR 27-MAY 01, 2011 CL Chicago, IL SP Triol Soc HO COSM DE lymphadenectomy; nontuberculous mycobacteria; outcome; parotidectomy; pediatrics ID CERVICAL LYMPHADENITIS; CHILDREN; ADENITIS; SURGERY; NECK; INFECTIONS; EXPERIENCE; DISEASES; HEAD AB Objectives: We examined surgical outcomes in children with cervicofacial nontuberculous mycobacterial lymphadenitis and attempted to identify predictors of complications. Methods: A retrospective chart review from 2 tertiary pediatric centers was used to identify 11 presentation or operative variables (age at surgery, gender, symptom duration, pain, violaceous skin changes, skin breakdown, fluctuance, purified protein derivative positivity, operative procedure, use of nerve integrity monitoring, and use of skin flap advancement) and to compare these to 5 postoperative complications (facial nerve dysfunction [paresis or paralysis], poor scarring, recurrence, wound infection, and wound dehiscence without infection). Results: The 45 patients analyzed for presentation or operative variables (28 female, 17 male; average age, 31.2 months) typically presented with painless masses averaging 8.2 weeks in duration, along with violaceous skin changes in 29 of the 45 cases (64%) and skin breakdown in 9 cases (20%). The surgical procedures included parotidectomy with or without selective lymphadenectomy in 38 of the 45 cases (84%) and lymphadenectomy alone in 7 cases (16%). Skin resection and cervicofacial advancement flap reconstruction was performed in 20 cases (44%). Nerve integrity monitoring was utilized in 32 cases (71%). In the 44 patients analyzed for postoperative complications, we found facial nerve paresis in 14 (31.8%), poor scarring in 9(20.5%), wound infection in 6(13.6%), recurrence in 4 (9.1%), and facial nerve paralysis in 2 (4.5%). Nine of the 14 cases (64.3%) of initial facial nerve paresis resolved. At final follow-up, facial nerve paresis persisted in 5 of the 14 children (35.7%) with initial postoperative paresis and in 1 of the 2 children (50.0%) with initial postoperative paralysis. Facial nerve paralysis persisted in the other child with initial postoperative paralysis. Overall, 6 of these 7 patients (85.7%) with persistent facial nerve dysfunction had follow-up of less than 1 month. All transient and permanent facial nerve dysfunction was in the distribution of the marginal mandibular nerve only. No statistically significant predictors of complications were identified. Conclusions: We report acceptable but not insignificant rates of marginal mandibular distribution facial nerve injury, poor scarring, wound infection, and recurrence following resection of cervicofacial nontuberculous mycobacterial lymphadenitis in children that must be discussed with patients and parents before operation. No presentation or operative variables predicted the complications. C1 [Parker, Noah P.; Scott, Andrew R.; Tibesar, Robert J.; Lander, Timothy A.; Sidman, James D.] Univ Minnesota, Childrens Hosp, Pediat ENT Associates, Minneapolis, MN USA. [Finkelstein, Marsha] Univ Minnesota, Childrens Hosp, Dept Clin Care Innovat & Res, Minneapolis, MN USA. [Parker, Noah P.; Scott, Andrew R.; Tibesar, Robert J.; Lander, Timothy A.; Rimell, Frank L.; Sidman, James D.] Univ Minnesota, Clin Minnesota, Minneapolis, MN USA. [Parker, Noah P.; Scott, Andrew R.; Tibesar, Robert J.; Lander, Timothy A.; Rimell, Frank L.; Sidman, James D.] Univ Minnesota, Dept Otolaryngol Head & Neck Surg, Minneapolis, MN USA. [Sidman, James D.] Medtronic Inc, Minneapolis, MN USA. RP Sidman, JD (reprint author), Childrens Specialty Ctr, Pediat ENT Associates, 2530 Chicago Ave S,Suite 450, Minneapolis, MN 55404 USA. CR ALESSI DP, 1988, ARCH OTOLARYNGOL, V114, P664 Flint D, 2000, INT J PEDIATR OTORHI, V53, P187, DOI 10.1016/S0165-5876(00)82006-6 Griffith DE, 2007, AM J RESP CRIT CARE, V175, P367, DOI 10.1164/rccm.200604-571ST Harris RL, 2009, INT J PEDIATR OTORHI, V73, P1297, DOI 10.1016/j.ijporl.2009.06.006 Hazra R, 1999, CLIN INFECT DIS, V28, P123, DOI 10.1086/515091 KENNEDY TL, 1992, ARCH OTOLARYNGOL, V118, P759 Lindeboom JA, 2007, CLIN INFECT DIS, V44, P1057, DOI 10.1086/512675 Maltezou HC, 1999, PEDIATR INFECT DIS J, V18, P968, DOI 10.1097/00006454-199911000-00006 MEHLE ME, 1993, LARYNGOSCOPE, V103, P386 Mustoe TA, 2002, PLAST RECONSTR SURG, V110, P560, DOI 10.1097/00006534-200208000-00031 NICHOLS RD, 1979, LARYNGOSCOPE, V89, P1930 OBRIEN RJ, 1987, AM REV RESPIR DIS, V135, P1007 OLSON NR, 1981, LARYNGOSCOPE, V91, P1714 Panesar J, 2003, LARYNGOSCOPE, V113, P149, DOI 10.1097/00005537-200301000-00028 Pilkington EF, 2010, INT J PEDIATR OTORHI, V74, P343, DOI 10.1016/j.ijporl.2009.08.029 Rahal A, 2001, LARYNGOSCOPE, V111, P1791, DOI 10.1097/00005537-200110000-00024 SIGALET D, 1992, J PEDIATR SURG, V27, P1381, DOI 10.1016/0022-3468(92)90181-6 STEWART MG, 1994, ARCH OTOLARYNGOL, V120, P873 Suskind DL, 1997, CLIN PEDIATR, V36, P403, DOI 10.1177/000992289703600705 TESSIER MH, 1994, LANCET, V344, P1778, DOI 10.1016/S0140-6736(94)92920-3 TUNKEL DE, 1995, LARYNGOSCOPE, V105, P1024, DOI 10.1288/00005537-199510000-00002 Tunkel DE, 1999, ARCH OTOLARYNGOL, V125, P1109 Wei JL, 2008, OTOLARYNG HEAD NECK, V138, P566, DOI 10.1016/j.otohns.2008.01.022 WOLINSKY E, 1995, CLIN INFECT DIS, V20, P954 Wright JE, 1996, AUST NZ J SURG, V66, P225, DOI 10.1111/j.1445-2197.1996.tb01170.x NR 25 TC 3 Z9 3 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD JUL PY 2012 VL 121 IS 7 BP 478 EP 484 PG 7 WC Otorhinolaryngology SC Otorhinolaryngology GA 973XT UT WOS:000306394500009 PM 22844868 ER PT J AU Koo, HJ Burns, JA Kobler, JB Heaton, JT Zeitels, SM AF Koo, Hae Jin Burns, James A. Kobler, James B. Heaton, James T. Zeitels, Steven M. TI Novel Device for Tissue Cooling During Endoscopic Laryngeal Laser Surgery: Thermal Damage Study in an Ex Vivo Calf Model SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE cooling; laser; microlaryngoscopy; thermal damage; vocal cord; vocal fold ID CO2-LASER SURGERY; THULIUM LASER; COMPLICATIONS; TEMPERATURE; LESIONS; AIR AB Objectives: Minimizing collateral thermal damage during endoscopic laryngeal laser surgery remains a priority, and tissue cooling is one way to achieve this goal. Cooling systems utilizing compressed air have been shown to reduce the extent of thermal trauma on the vocal folds, but these units are not ideal for endoscopic applications because cooling is inefficient at the low airflows needed. We examined whether a novel vortex cooling device that generates cooled air at low flow rates would provide a cooling benefit beyond that which could be obtained by using room-temperature air for cooling tissue or by using no cooling during simulated laryngeal laser surgery. Methods: A continuous-wave thulium laser was used to incise glottic tissue in 12 calf vocal folds. Cooling was achieved with a prototype vortex cooler (9 degrees C air output; flow rate, 3 L/min), and tissue temperature measurements were compared to those with room-air cooling and no cooling. Thermal damage was analyzed histologically by measuring the depth of lactate dehydrogenase inactivation surrounding the mucosal incision. The cooling conditions were tested during time-constant cuts (8 seconds) and depth-constant cuts (into the thyroarytenoid muscle). Results: During time-constant cuts, comparison between vortex cooling and room-air cooling revealed that vortex cooling resulted in a thermal damage zone that was 14% smaller (519 versus 603 mu m; p < 0.05). During depth-constant cuts, vortex cooling created a thermal damage zone that was 32% smaller than that created with no cooling (p < 0.01) and 9% smaller than that created with room-air cooling (p < 0.01). Conclusions: Vortex cooling reduces thermal damage more effectively than room-air cooling or no cooling during both time-constant and depth-constant thulium laser cuts. C1 [Burns, James A.] Massachusetts Gen Hosp, Ctr Laryngeal Surg & Voice Rehabil, Boston, MA 02114 USA. Harvard Univ, Sch Med, Dept Surg, Boston, MA 02115 USA. RP Burns, JA (reprint author), Massachusetts Gen Hosp, Ctr Laryngeal Surg & Voice Rehabil, 1 Bowdoin Sq,11th Floor, Boston, MA 02114 USA. FU Institute of Laryngology and Voice Restoration; The "V" Foundation FX From the Department of Surgery, Harvard Medical School, and the Center for Laryngeal Surgery and Voice Rehabilitation, Massachusetts General Hospital, Boston, Massachusetts. Mr Koo is currently at the Korea Advanced Institute of Technology, Daejeon, Republic of Korea. This work was supported in part by the Institute of Laryngology and Voice Restoration and The "V" Foundation. CR ANNYAS AA, 1984, LARYNGOSCOPE, V94, P836 Burns JA, 2010, ANN OTO RHINOL LARYN, V119, P684 Burns JA, 2007, ANN OTO RHINOL LARYN, V116, P853 HEALY GB, 1984, OTOLARYNG HEAD NECK, V92, P13 Khan MH, 2005, LASER SURG MED, V36, P270, DOI 10.1002/lsm.20142 Laubach H, 2007, LASER SURG MED, V39, P14, DOI 10.1002/lsm.20453 MEYERS A, 1981, ANN OTO RHINOL LARYN, V90, P132 Ranque GJ, 1933, J PHYS RADIUM, V4, p112S Sherwood ME, 2007, LASER SURG MED, V39, P128, DOI 10.1002/lsm.20450 STERN LS, 1980, LARYNGOSCOPE, V90, P792 Zeitels SM, 2006, ANN OTO RHINOL LARYN, V115, P891 NR 11 TC 2 Z9 2 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD JUL PY 2012 VL 121 IS 7 BP 485 EP 489 PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA 973XT UT WOS:000306394500010 PM 22844869 ER PT J AU Mallur, PS Gartner-Schmidt, J Rosen, CA AF Mallur, Pavan S. Gartner-Schmidt, Jacqueline Rosen, Clark A. TI Voice Outcomes Following the Gray Minithyrotomy SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article; Proceedings Paper CT Meeting of the American-Broncho-Esophagological-Association CY APR 27-28, 2011 CL Chicago, IL SP Amer Broncho Esophagol Assoc DE Gray minithyrotomy; sulcus vocalis; vocal fold scar ID VOCAL FOLD SCAR; AUTOLOGOUS FAT IMPLANTATION; SULCUS VOCALIS; GLOTTIC INSUFFICIENCY; AUGMENTATION; MANAGEMENT AB Objectives: Most practitioners have limited treatment options for vocal fold scar and sulcus vocalis. The Gray minithyrotomy (GMT) is a surgical procedure for the treatment of these conditions, although limited objective data exist regarding voice outcomes. This study compares the quantified subjective and visual perceptual outcomes following GMT for the treatment of vocal fold scar and sulcus vocalis. Methods: We performed a retrospective review of patients who underwent GMT in a single institution. Patient-reported satisfaction, Voice Handicap Index-10 scores, results of video perceptual analysis, and complications were recorded. Results: Sixteen patients underwent GMT for phonotraumatic or postoperative scar (11), radiation-induced scar (3), or sulcus vocalis (2). Seven underwent bilateral operations. Follow-up data were available for 12 patients. Eight patients had 2 or more failed surgical interventions before GMT. Seven of the 13 procedures resulted in a self-reported improvement. Although the mean preoperative Voice Handicap Index-10 score (30.6) across all patients did not decrease after the operation, 6 of the 13 GMT procedures resulted in improvement (mean decrease, 7.5). Complications, encountered in 5 patients, included ecchymosis, neck abscess, tongue numbness, wound dehiscence, and aspiration pneumonia. Conclusions: The GMT is a viable treatment for severe vocal fold scar and sulcus vocalis. Our results show improvement in half of a cohort that was marked by previous failures at improving voice. These results point to the recalcitrant nature of voice difficulties in treating vocal fold scar and sulcus, and may properly guide clinicians and patients in their expectations following this infrequently used technique. C1 [Mallur, Pavan S.; Gartner-Schmidt, Jacqueline; Rosen, Clark A.] Univ Pittsburgh, Dept Otolaryngol Head & Neck Surg, Univ Pittsburgh Voice Ctr, Sch Med, Pittsburgh, PA 15219 USA. RP Rosen, CA (reprint author), Univ Pittsburgh, Dept Otolaryngol Head & Neck Surg, Univ Pittsburgh Voice Ctr, Sch Med, 1400 Locust St, Pittsburgh, PA 15219 USA. CR Björck G, 2002, Logoped Phoniatr Vocol, V27, P4, DOI 10.1080/140154302760146925 Ford CN, 1996, ANN OTO RHINOL LARYN, V105, P189 Giovanni A, 2007, EUR ARCH OTO-RHINO-L, V264, P337, DOI 10.1007/s00405-006-0230-8 Gray SD, 1999, ANN OTO RHINOL LARYN, V108, P1 Hertegard S, 2002, LARYNGOSCOPE, V112, P2211, DOI 10.1097/00005537-200212000-00016 Hsiung MW, 2000, LARYNGOSCOPE, V110, P1026, DOI 10.1097/00005537-200006000-00026 Neuenschwander MC, 2001, J VOICE, V15, P295, DOI 10.1016/S0892-1997(01)00031-5 Paniello RC, 2008, ANN OTO RHINOL LARYN, V117, P437 PONTES P, 1993, J VOICE, V7, P365, DOI 10.1016/S0892-1997(05)80260-7 Remacle Marc, 2007, Curr Opin Otolaryngol Head Neck Surg, V15, P148, DOI 10.1097/MOO.0b013e3281084e74 Rosen CA, 2005, LARYNGOSCOPE, V115, P1681, DOI 10.1097/01.MLG.0000175538.89627.0D Rosen CA, 2000, OTOLARYNG CLIN N AM, V33, P1081, DOI 10.1016/S0030-6665(05)70266-8 Rosen CA, 2008, OPERATIVE TECHNIQUES Rosen CA, 2004, LARYNGOSCOPE, V114, P1549, DOI 10.1097/00005537-200409000-00009 Sataloff RT, 1997, J VOICE, V11, P238 Tan ML, 2011, J VOICE, V25, P619, DOI 10.1016/j.jvoice.2010.08.001 NR 16 TC 2 Z9 2 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD JUL PY 2012 VL 121 IS 7 BP 490 EP 496 PG 7 WC Otorhinolaryngology SC Otorhinolaryngology GA 973XT UT WOS:000306394500011 PM 22844870 ER PT J AU Kunduk, M Dollinger, M McWhorter, AJ Svec, JG Lohscheller, J AF Kunduk, Melda Doellinger, Michael McWhorter, Andrew J. Svec, Jan G. Lohscheller, Joerg TI Vocal Fold Vibratory Behavior Changes Following Surgical Treatment of Polyps Investigated With High-Speed Videoendoscopy and Phonovibrography SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article; Proceedings Paper CT Annual Meeting of the American-Laryngological-Association/Combined Otolaryngological Spring Meetings CY APR 27-28, 2011 CL Chicago, IL SP Amer Laryngol Assoc DE high-speed videoendoscopy; phonovibrography; vocal fold vibration; voice ID DYNAMICS; VIDEOKYMOGRAPHY; VISUALIZATION; MANAGEMENT; RECORDINGS; VIBRATIONS; DISORDERS; SPEAKERS; HEALTHY AB Objectives: The goal of this study was to objectively quantify the changes in vocal fold vibratory characteristics before and after surgery with high-speed videoendoscopy and the image analysis tool phonovibrography. Methods: High-speed videoendoscopic data, audio recordings, and Voice Handicap Index scores were collected from 8 subjects with a diagnosis of unilateral vocal fold polyps, before operation and at 1 week and 1 to 3 months after operation. We then analyzed the objective phonovibrographic patterns and parameters describing the vocal fold vibratory behavior. Results: On phonovibrography, the visual representations of the vocal fold vibratory characteristics, from both the individual and the group data, demonstrated very different patterns before surgery and both 1 week and 1 to 3 months after surgery. The individual phonovibrograms obtained from the left and right true vocal folds clearly demonstrated the lesion site and its effects on the vocal fold vibratory characteristics for each subject. The improvements in amplitude and symmetry (relative vibratory amplitude and vibration amplitude symmetry) of vocal fold vibration were quantified; the difference was greatest between data from before surgery and data from 1 week after surgery. Conclusions: The visual phonovibrographic patterns and quantitative data revealed marked changes in vocal fold vibratory patterns after operation and continued improvement at 1 to 3 months. C1 [Kunduk, Melda] Louisiana State Univ, Dept Commun Sci & Disorders, Baton Rouge, LA 70803 USA. [Kunduk, Melda; McWhorter, Andrew J.] Louisiana State Univ, Hlth Sci Ctr, Dept Otolaryngol Head & Neck Surg, Voice Ctr,Our Lady Lake Reg Med Ctr, Baton Rouge, LA 70803 USA. [Doellinger, Michael] Univ Hosp Erlangen, Sch Med, Dept Phoniatr & Pediat Audiol, Erlangen, Germany. [Lohscheller, Joerg] Univ Appl Sci Trier, Dept Comp Sci & Med Informat, Trier, Germany. [Svec, Jan G.] Palacky Univ, Dept Biophys, Fac Sci, CR-77147 Olomouc, Czech Republic. RP Kunduk, M (reprint author), Louisiana State Univ, Dept Commun Sci & Disorders, 64 Hatcher Hall, Baton Rouge, LA 70803 USA. RI Svec, Jan/C-6909-2008 OI Svec, Jan/0000-0001-5095-7415 CR Bless D M, 1987, Ear Nose Throat J, V66, P289 Bonilha HS, 2008, J VOICE, V22, P699, DOI 10.1016/j.jvoice.2007.03.002 Bonilha HS, 2008, AM J SPEECH-LANG PAT, V17, P367, DOI 10.1044/1058-0360(2008/07-0059) Cohen SM, 2007, OTOLARYNG HEAD NECK, V136, P742, DOI 10.1016/j.otohns.2006.12.009 Colton RH, 2006, UNDERSTANDING VOICE Deliyski DD, 2008, FOLIA PHONIATR LOGO, V60, P33, DOI 10.1159/000111802 Doellinger M, 2009, CURRENT BIOINFORMATI, V4, P1 Giovanni A, 1999, LARYNGOSCOPE, V109, P656, DOI 10.1097/00005537-199904000-00026 Inwald EC, 2011, J VOICE, V25, P576, DOI 10.1016/j.jvoice.2010.04.004 Ishikawa K, 2010, J VOICE, V24, P379, DOI 10.1016/j.jvoice.2008.10.011 Jacobson BH, 1997, AM J SPEECH-LANG PAT, V6, P66 Kendall KA, 2009, ARCH OTOLARYNGOL, V135, P274, DOI 10.1001/archoto.2008.557 Kunduk M, 2010, LARYNGOSCOPE, V120, P981, DOI 10.1002/lary.20832 Kunduk Melda, 2006, Logoped Phoniatr Vocol, V31, P139, DOI 10.1080/14015430500364065 Lohscheller J, 2008, LARYNGOSCOPE, V118, P753, DOI 10.1097/MLG.0b013e318161f9e1 Lohscheller J, 2008, IEEE T MED IMAGING, V27, P300, DOI 10.1109/TMI.2007.903690 Mehta DD, 2010, ANN OTO RHINOL LARYN, V119, P1 Mehta DD, 2011, J SPEECH LANG HEAR R, V54, P47, DOI 10.1044/1092-4388(2010/10-0026) Patel R, 2008, ANN OTO RHINOL LARYN, V117, P413 Qiu QJ, 2006, LARYNGOSCOPE, V116, P1824, DOI 10.1097/01.mlg.0000233552.58895.d0 Ragab SM, 2005, J LARYNGOL OTOL, V119, P961 Shaw HS, 2008, J VOICE, V22, P23, DOI 10.1016/j.jvoice.2006.08.006 Svec JG, 2007, ANN OTO RHINOL LARYN, V116, P172 Voigt D, 2010, ARTIF INTELL MED, V49, P51, DOI 10.1016/j.artmed.2010.01.001 Voigt D, 2010, COMPUT METH PROG BIO, V99, P275, DOI 10.1016/j.cmpb.2010.01.004 Zeitels SM, 2002, ANN OTO RHINOL LARYN, V111, P21 NR 26 TC 3 Z9 3 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD JUN PY 2012 VL 121 IS 6 BP 355 EP 363 PG 9 WC Otorhinolaryngology SC Otorhinolaryngology GA 958AF UT WOS:000305207500001 PM 22737957 ER PT J AU Titze, IR Klemuk, SA Lu, XY AF Titze, Ingo R. Klemuk, Sarah A. Lu, Xiaoying TI Adhesion of a Monolayer of Fibroblast Cells to Fibronectin Under Sonic Vibrations in a Bioreactor SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE adhesion; bioreactor; cell vibration; sonic frequency ID LOW AUDIO FREQUENCIES; VOCAL-FOLD; STRESS; MATRIX; BIOMATERIALS; RHEOMETER; MECHANICS; GROWTH AB Objectives: We examined cell adhesion to a surface under vibrational forces approximating those of phonation. Methods: A monolayer of human fibroblast cells was seeded on a fibronectin-coated glass coverslip, which was attached to either the rotating part or the stationary part of a rheometer-bioreactor. The temperature, humidity, carbon dioxide level, nutrients, and cell seeding density were controlled. The cell density was on the order of 1,000 to 5,000 cells per square millimeter. Target stresses above 1 kPa at an oscillatory frequency of 100 Hz were chosen to reflect conditions of vocal fold tissue vibration. Results: Fibronectin coating provided enough adhesion to support at least 2 kPa of oscillating stress, but only about 0.1 kPa of steady rotational shear. For stresses exceeding those limits, the cells were not able to adhere to the thin film of fibronectin. Conclusions: Cells will adhere to a planar surface under stresses typical of phonation, which provide a more stringent test than adherence in a 3-dimensional matrix. The density of cell seeding on the coverslip played a role in cell extracellular matrix adhesion, in that the cells adhered to each other more than to the fibronectin coating when the cells were nearly confluent. C1 [Titze, Ingo R.] Natl Ctr Voice & Speech, Salt Lake City, UT 84101 USA. [Titze, Ingo R.; Klemuk, Sarah A.; Lu, Xiaoying] Univ Iowa, Dept Commun Sci & Disorders, Iowa City, IA USA. [Titze, Ingo R.] Univ Utah, Salt Lake City, UT USA. RP Titze, IR (reprint author), Natl Ctr Voice & Speech, 136 S Main St,Suite 320, Salt Lake City, UT 84101 USA. FU National Institute on Deafness and Other Communication Disorders [R01-DC 4224-05] FX From the Department of Communication Sciences and Disorders, The University of Iowa, Iowa City, Iowa (all authors), and the National Center for Voice and Speech (Titze) and the University of Utah (Titze), Salt Lake City, Utah. The work was supported by grant R01-DC 4224-05 from the National Institute on Deafness and Other Communication Disorders. CR Alberts B, 1994, MOL BIOL CELL, P1139 Cha JM, 2006, ARTIF ORGANS, V30, P250, DOI 10.1111/j.1525-1594.2006.00212.x Chan RW, 2004, J ACOUST SOC AM, V115, P3161, DOI 10.1121/1.1736272 Chen CS, 2004, ANNU REV BIOMED ENG, V6, P275, DOI 10.1146/annurev.bioeng.6.040803.140040 Collinsworth A. M., 2002, AM J PHYSIOL-CELL PH, V283, P1219 Damean N, 2005, P NATL ACAD SCI USA, V102, P10035, DOI 10.1073/pnas.0504712102 De R, 2007, NAT PHYS, V3, P655, DOI 10.1038/nphys680 Ferry JD, 1980, VISCOELASTIC PROPERT, V3rd FREEDMAN VH, 1974, CELL, V3, P355, DOI 10.1016/0092-8674(74)90050-6 FRIES KM, 1994, CLIN IMMUNOL IMMUNOP, V72, P283, DOI 10.1006/clin.1994.1144 Fuja TJ, 2006, MATRIX BIOL, V25, P240, DOI 10.1016/j.matbio.2006.01.004 Fung FC, 1984, BIODYNAMICS CIRCULAT Gao M, 2006, PHYS CHEM CHEM PHYS, V8, P3692, DOI 10.1039/b606019f Gray S, 1993, VOCAL FOLD PHYSL FRO, P1 Gray SD, 2000, OTOLARYNG CLIN N AM, V33, P679, DOI 10.1016/S0030-6665(05)70237-1 Hayakawa K, 2001, EXP CELL RES, V268, P104, DOI 10.1006/excr.2001.5270 Hirano M., 1975, OTOLOGIA FUKUOKA S1, V21, P239 ITO T, 1987, CANCER RES, V47, P4146 Janmey PA, 2007, ANNU REV BIOMED ENG, V9, P1, DOI 10.1146/annurev.bioeng.9.060906.151927 JIANG JJQ, 1994, J VOICE, V8, P132, DOI 10.1016/S0892-1997(05)80305-4 Klemuk SA, 2009, J RHEOL, V53, P765, DOI 10.1122/1.3119056 Klemuk SA, 2008, J ACOUST SOC AM, V124, P2330, DOI 10.1121/1.2973183 Klemuk SA, 2004, LARYNGOSCOPE, V114, P1597, DOI 10.1097/00005537-200409000-00018 Kriegler M, 1990, GENE TRANSFER EXPRES, P94 Maheshwari G, 1999, BIOPHYS J, V76, P2814 Mao Y, 2005, MATRIX BIOL, V24, P389, DOI 10.1016/j.matbio.2005.06.008 Mihashi S, 1981, VOCAL FOLD PHYSL, P45 Reamer R, 1995, J AOAC INT, V78, P997 Sarojini H, 2008, J CELL BIOCHEM, V104, P1793, DOI 10.1002/jcb.21748 Sato K, 2001, ANN OTO RHINOL LARYN, V110, P319 SCHRAG JL, 1977, T SOC RHEOL, V21, P399 STEWART GJ, 1995, BIOTECHNIQUES, V19, P598 Titze IR, 2007, J ACOUST SOC AM, V121, P469, DOI 10.1121/1.2390676 Titze IR, 2004, J ACOUST SOC AM, V115, P392, DOI 10.1121/1.1631941 Volmer MW, 2004, PROTEOMICS, V4, P1324, DOI 10.1002/pmic.200300703 NR 35 TC 0 Z9 0 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD JUN PY 2012 VL 121 IS 6 BP 364 EP 374 PG 11 WC Otorhinolaryngology SC Otorhinolaryngology GA 958AF UT WOS:000305207500002 PM 22737958 ER PT J AU Han, YJ Lee, HS Kim, SW Hong, JC Kim, ST Park, HS Lee, KD AF Han, Young Jin Lee, Hyoung Shin Kim, Sung Won Hong, Jong Chul Kim, Seung Tae Park, Hyo Sang Lee, Kang Dae TI Transoral Laser Microsurgery of Recurrent Early Glottic Cancer After Radiation Therapy: Clinical Feasibility and Limitations SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE glottic cancer; radiation therapy; recurrence; salvage; transoral laser microsurgery ID SUPRACRICOID PARTIAL LARYNGECTOMY; WHOLE-ORGAN SECTIONS; SALVAGE SURGERY; IRRADIATION FAILURE; CO2-LASER SURGERY; CARCINOMA; RADIOTHERAPY; LARYNX; COMPLICATIONS; SPREAD AB Objectives: Transoral laser microsurgery (TLM) is an accepted alternative to open partial laryngectomy for selected glottic cancers, but its role in salvage of radiation failure is debated. Methods: The records of 18 patients treated by TLM for rT1 and rT2 glottic cancer after curative radiation therapy from 2002 to 2007 were retrospectively analyzed. Results: Of the 18 patients, 10 (56%) remained free of disease after the first TLM. The 5-year local control and laryngeal preservation rates showed better outcomes in rpT1 tumors than in rpT2 tumors (87.5% versus 16.6%, p = 0.02; and 87.5% versus 33.3%, p = 0.03, respectively). However, the 5-year overall survival and disease-specific survival rates showed no significant difference between rpT1 and rpT2 tumors. Conclusions: TLM can be a relatively safe and effective salvage option for rT1 glottic cancer. However, because of its high local recurrence rate, TLM may not be generally recommended for rT2 glottic cancer. C1 [Han, Young Jin; Kim, Sung Won; Kim, Seung Tae; Park, Hyo Sang; Lee, Kang Dae] Kosin Univ, Coll Med, Dept Otolaryngol Head & Neck Surg, Pusan, South Korea. [Lee, Hyoung Shin] Kosin Univ, Grad Sch, Dept Otolaryngol Head & Neck Surg, Pusan, South Korea. [Hong, Jong Chul] Dong A Univ, Coll Med, Dept Otolaryngol Head & Neck Surg, Pusan, South Korea. RP Lee, KD (reprint author), 34 Amnam Dong, Pusan 602702, South Korea. CR Ambrosch Petra, 2007, Curr Opin Otolaryngol Head Neck Surg, V15, P82, DOI 10.1097/MOO.0b013e3280147336 Ansarin M, 2007, ARCH OTOLARYNGOL, V133, P1193, DOI 10.1001/archotol.133.12.1193 Clark J, 2005, ANZ J SURG, V75, P958, DOI 10.1111/j.1445-2197.2005.03587.x de Gier HHW, 2001, HEAD NECK-J SCI SPEC, V23, P177, DOI 10.1002/1097-0347(200103)23:3<177::AID-HED1015>3.0.CO;2-8 Eckel HE, 1998, LASER SURG MED, V23, P79, DOI 10.1002/(SICI)1096-9101(1998)23:2<79::AID-LSM5>3.0.CO;2-S Ganly I, 2009, HEAD NECK-J SCI SPEC, V31, P338, DOI 10.1002/hed.20975 Ganly I, 2006, ARCH OTOLARYNGOL, V132, P59, DOI 10.1001/archotol.132.1.59 Garden AS, 2003, INT J RADIAT ONCOL, V55, P322, DOI 10.1016/S0360-3016(02)03938-X Grant DG, 2008, OTOLARYNG HEAD NECK, V138, P606, DOI 10.1016/j.otohns.2007.12.046 Grant DG, 2007, OTOLARYNG HEAD NECK, V137, P482, DOI 10.1016/j.otohns.2007.05.064 Hartl DM, 2007, ANN OTO RHINOL LARYN, V116, P832 Hinni ML, 2007, ARCH OTOLARYNGOL, V133, P1198, DOI 10.1001/archotol.133.12.1198 Holsinger FC, 2006, HEAD NECK-J SCI SPEC, V28, P779, DOI 10.1002/hed.20415 KIRCHNER JA, 1987, ACTA OTO-LARYNGOL, V103, P503 KIRCHNER JA, 1989, ANN OTO RHINOL LARYN, V98, P661 KOOPER DP, 1995, CLIN OTOLARYNGOL, V20, P167, DOI 10.1111/j.1365-2273.1995.tb00037.x Makeieff M, 2005, LARYNGOSCOPE, V115, P353, DOI 10.1097/01.mlg.0000154751.86431.41 Motamed M, 2006, LARYNGOSCOPE, V116, P451, DOI 10.1097/01.MLG.0000199591.92336.06 Nibu K, 1997, HEAD NECK-J SCI SPEC, V19, P116, DOI 10.1002/(SICI)1097-0347(199703)19:2<116::AID-HED5>3.0.CO;2-7 Pearson BW, 2003, LARYNGOSCOPE, V113, P1104, DOI 10.1097/00005537-200307000-00002 Piazza C, 2007, ARCH OTOLARYNGOL, V133, P1037, DOI 10.1001/archotol.133.10.1037 Puxeddu R, 2004, OTOLARYNG HEAD NECK, V130, P84, DOI 10.1016/j.otohns.2003.07.002 Quer M, 2000, HEAD NECK-J SCI SPEC, V22, P520, DOI 10.1002/1097-0347(200008)22:5<520::AID-HED13>3.0.CO;2-K Remacle M, 2007, EUR ARCH OTO-RHINO-L, V264, P499, DOI 10.1007/s00405-007-0279-z Remacle M, 2007, EUR ARCH OTO-RHINO-L, V264, P709, DOI 10.1007/s00405-007-0304-2 Roedel RMW, 2010, AURIS NASUS LARYNX, V37, P340, DOI 10.1016/j.anl.2009.07.004 Roedel RMW, 2010, AURIS NASUS LARYNX, V37, P474, DOI 10.1016/j.anl.2009.11.004 Sewnaik A, 2005, HEAD NECK-J SCI SPEC, V27, P101, DOI 10.1002/hed.20125 Silver CE, 2009, EUR ARCH OTO-RHINO-L, V266, P1333, DOI 10.1007/s00405-009-1028-2 Sjogren EV, 2008, HEAD NECK-J SCI SPEC, V30, P1167, DOI 10.1002/hed.20852 Spriano G, 2002, HEAD NECK-J SCI SPEC, V24, P759, DOI 10.1002/hed.10117 STEINER W, 1993, AM J OTOLARYNG, V14, P116, DOI 10.1016/0196-0709(93)90050-H Steiner W, 2004, HEAD NECK-J SCI SPEC, V26, P477, DOI 10.1002/hed.20009 Tamura Y, 2007, ACTA OTO-LARYNGOL, V557, P62, DOI DOI 10.1080/00016480601067990 VIANI L, 1991, CANCER, V67, P577, DOI 10.1002/1097-0142(19910201)67:3<577::AID-CNCR2820670309>3.0.CO;2-W Vilaseca I, 2010, HEAD NECK-J SCI SPEC, V32, P929, DOI 10.1002/hed.21288 Vilaseca-Gonzalez I, 2003, HEAD NECK-J SCI SPEC, V25, P382, DOI 10.1002/hed.10207 Watters GWR, 2000, CLIN OTOLARYNGOL, V25, P146, DOI 10.1046/j.1365-2273.2000.00333.x Yiotakis J, 2003, OTOLARYNG HEAD NECK, V128, P200, DOI 10.1067/mhn.2003.63 Zbaren P, 2007, HEAD NECK-J SCI SPEC, V29, P26, DOI 10.1002/hed.20502 NR 40 TC 2 Z9 2 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD JUN PY 2012 VL 121 IS 6 BP 375 EP 382 PG 8 WC Otorhinolaryngology SC Otorhinolaryngology GA 958AF UT WOS:000305207500003 PM 22737959 ER PT J AU Fujimoto, C Murofushi, T Sugasawa, K Chihara, Y Ushio, M Yamasoba, T Iwasaki, S AF Fujimoto, Chisato Murofushi, Toshihisa Sugasawa, Keiko Chihara, Yasuhiro Ushio, Muentaka Yamasoba, Tatsuya Iwasaki, Shinichi TI Bilateral Vestibulopathy With Dissociated Deficits in the Superior and Inferior Vestibular Systems SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE caloric test; clinical neurology examination; cranial neuropathy; dissociated bilateral vestibulopathy; vertigo; vestibular evoked myogenic potential ID EVOKED MYOGENIC POTENTIALS; GUINEA-PIG; RESPONSES; HEARING; NEURONS; REFLEX; CLICKS AB Objectives: The aim of this study was to reveal the clinical characteristics of dissociated bilateral vestibulopathy (BV) affecting the superior vestibular nerve system on one side and the inferior vestibular nerve system on the other side. It is probable that BV does not always show bilateral deficits of the same vestibular nerve system. Methods: In a retrospective study of 2,752 consecutive new patients, 1,560 patients had undergone both caloric testing and cervical vestibular evoked myogenic potential testing. All 1,560 patients had also undergone a battery of tests including standardized neurologic, neuro-otologic, neuro-ophthalmologic, and audiological examinations. Results: Forty-three patients (2.8% of 1,560 patients) were given a diagnosis of dissociated BV. Among them, 10 patients (23%) had Meniere's disease and 6 patients (14%) had vestibular neuritis. Eighteen patients (42%) did not have any identifiable disease involving the peripheral vestibule, and 9 patients (21%) could be regarded as having a novel subtype of idiopathic BV. Conclusions: Although dissociated BV might be induced by some of the same causes that provoke bilateral vestibular dysfunction, a definite proportion of the patients did not have any identifiable causes of dissociated vestibular dysfunction. Idiopathic cases could be categorized into a novel subtype of idiopathic BV. C1 [Fujimoto, Chisato] Univ Tokyo, Dept Otolaryngol, Fac Med, Bunkyo Ku, Tokyo, Japan. [Fujimoto, Chisato] Tokyo Metropolitan Neurol Hosp, Dept Neurootol, Tokyo, Japan. [Chihara, Yasuhiro] Kameda Gen Hosp, Dept Otolaryngol, Kamogawa, Japan. RP Fujimoto, C (reprint author), Univ Tokyo, Dept Otolaryngol, Fac Med, Bunkyo Ku, 7-3-1 Hongo, Tokyo, Japan. CR Arbusow V, 1998, J NEUROL, V245, P132, DOI 10.1007/s004150050192 BALOH RW, 1989, NEUROLOGY, V39, P272 Bath AP, 1999, CLIN OTOLARYNGOL, V24, P181, DOI 10.1046/j.1365-2273.1999.00234.x Brandt T, 2005, BRAIN, V128, P2732, DOI 10.1093/brain/awh617 COLEBATCH JG, 1992, NEUROLOGY, V42, P1635 COLEBATCH JG, 1994, J NEUROL NEUROSUR PS, V57, P190, DOI 10.1136/jnnp.57.2.190 Fujimoto C, 2005, ACTA OTO-LARYNGOL, V125, P430, DOI 10.1080/00016480410024668 Fujimoto C, 2009, J NEUROL, V256, P1488, DOI 10.1007/s00415-009-5147-x Huppert D, 2010, ACTA OTO-LARYNGOL, V130, P644, DOI 10.3109/00016480903382808 Matsuzaki M, 2001, ORL-J OTO-RHIN-LARYN, V63, P349, DOI 10.1159/000055772 Murofushi T, 1996, EXP BRAIN RES, V111, P149 Murofushi T, 2009, NEUROPATHIES OF THE AUDITORY AND VESTIBULAR EIGHTH CRANIAL NERVES, P85, DOI 10.1007/978-4-431-09433-3_10 Murofushi T, 1997, ACTA OTO-LARYNGOL, V117, P66, DOI 10.3109/00016489709117994 Murofushi T, 1998, ARCH OTOLARYNGOL, V124, P509 MUROFUSHI T, 1995, EXP BRAIN RES, V103, P174 RINNE T, 1995, ACTA OTO-LARYNGOL, P247 Sargent EW, 1997, OTOLARYNG HEAD NECK, V116, P157, DOI 10.1016/S0194-5998(97)70318-8 Schmal F, 2005, J VESTIBUL RES-EQUIL, V15, P215 TELIAN SA, 1991, OTOLARYNG HEAD NECK, V104, P67 VIBERT D, 1995, ACTA OTO-LARYNGOL, V115, P611, DOI 10.3109/00016489509139375 Young YH, 2003, ARCH OTOLARYNGOL, V129, P815, DOI 10.1001/archotol.129.8.815 Zingler VC, 2007, ANN NEUROL, V61, P524, DOI 10.1002/ana.21105 Zingler VC, 2008, J NEUROL, V255, P1332, DOI 10.1007/s00415-008-0887-6 NR 23 TC 0 Z9 0 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD JUN PY 2012 VL 121 IS 6 BP 383 EP 388 PG 6 WC Otorhinolaryngology SC Otorhinolaryngology GA 958AF UT WOS:000305207500004 PM 22737960 ER PT J AU Weber, ME Yiannias, JA Hougeir, FG Kyle, A Noble, BN Landry, AM Hinni, ML AF Weber, Megan E. Yiannias, James A. Hougeir, Firas G. Kyle, Amber Noble, Brie N. Landry, April M. Hinni, Michael L. TI Intraoral Metal Contact Allergy as a Possible Risk Factor for Oral Squamous Cell Carcinoma SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE hypersensitivity; lichen planus; oral neoplasm; patch test ID OF-THE-LITERATURE; LICHEN-PLANUS AB Objectives: Intraoral exposure to dental restorations can cause contact allergy that may induce carcinogenesis. We investigated the relationship of intraoral metal contact allergy to epithelial carcinogenesis. Methods: The prevalence of positive patch test reactions to dental restoration metals in 65 prospectively enrolled patients with newly or previously diagnosed oral squamous cell carcinoma (SCC) was compared to that in 48 control patients. The relative risk of oral SCC was estimated by calculating odds ratios for exposure to dental metals resulting in allergy. Results: Of the 65 patients with oral SCC, 34% were allergic to at least 1 adjacent metal. They were 1.57 times as likely as control patients to have metal contact allergy (odds ratio, 1.57; 95% confidence interval, 0.65 to 3.80) and more than 3 times as likely to react to mercury (odds ratio, 3.20; 95% confidence interval, 0.42 to 33.20). Conclusions: Patients with oral SCC who have metal dental restorations should undergo patch testing and possible removal of the restorations if their reactions are positive. C1 [Landry, April M.; Hinni, Michael L.] Mayo Clin, Dept Otolaryngol Head & Neck Surg, Phoenix, AZ 85054 USA. [Weber, Megan E.; Yiannias, James A.; Hougeir, Firas G.; Kyle, Amber] Mayo Clin, Dept Dermatol, Phoenix, AZ 85054 USA. [Noble, Brie N.] Mayo Clin, Dept Biostat, Phoenix, AZ 85054 USA. RP Hinni, ML (reprint author), Mayo Clin, Dept Otolaryngol Head & Neck Surg, 5777 E Mayo Blvd, Phoenix, AZ 85054 USA. CR Camisa C, 1998, CUTIS, V62, P175 GIUNTA JL, 1979, J PROSTHET DENT, V42, P188, DOI 10.1016/0022-3913(79)90173-2 Hougeir FG, 2006, INT J DERMATOL, V45, P265, DOI 10.1111/j.1365-4632.2004.02417.x Ibbotson SH, 1996, BRIT J DERMATOL, V134, P420, DOI 10.1111/j.1365-2133.1996.tb16224.x KRUTCHKOFF DJ, 1978, J ORAL PATHOL MED, V7, P1, DOI 10.1111/j.1600-0714.1978.tb01879.x LIND PO, 1986, SCAND J DENT RES, V94, P448 Lo Muzio L, 1998, ORAL ONCOL, V34, P239, DOI 10.1016/S1368-8375(98)80001-8 Pang BK, 1996, CONTACT DERMATITIS, V35, P70 Yiannias JA, 2000, J AM ACAD DERMATOL, V42, P177, DOI 10.1016/S0190-9622(00)90123-3 NR 9 TC 1 Z9 1 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD JUN PY 2012 VL 121 IS 6 BP 389 EP 394 PG 6 WC Otorhinolaryngology SC Otorhinolaryngology GA 958AF UT WOS:000305207500005 PM 22737961 ER PT J AU Thomas, L Moore, EJ Olsen, KD Kasperbauer, JL AF Thomas, Ligy Moore, Eric J. Olsen, Kerry D. Kasperbauer, Jan L. TI Long-Term Quality of Life in Young Adults Treated for Oral Cavity Squamous Cell Cancer SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE long-term quality of life; MDADI; M. D.Anderson Dysphagia Inventory; oral cancer; swallowing function; University of Washington Quality of Life questionnaire; UW-QOL; young adult ID SUPRAOMOHYOID NECK DISSECTION; OROPHARYNGEAL CANCER; PRIMARY SURGERY; LEVEL-IIB; HEAD; CARCINOMA; OUTCOMES; QUESTIONNAIRE; DYSPHAGIA; LARYNGEAL AB Objectives: We assessed the long-term quality of life (QOL) in patients who survived oral cavity squamous cell cancer when they were young and looked for any clinical factors that might adversely affect function and QOL. Methods: We performed a retrospective case series and questionnaire survey in a tertiary care center. The subjects were consecutive patients treated for oral cancers during a 25-year period, when they were 40 years of age or less. The patients completed the University of Washington Quality of Life questionnaire and the M. D. Anderson Dysphagia Inventory (MDADI). We made an overall descriptive report of swallowing and QOL measures in the study population and looked for any clinical factors associated with functional outcomes. Results: Among the 62 patients treated over the course of 25 years, 46 were alive and disease-free. Twenty-six participated. The median follow-up duration was 14.7 years (range, 3 to 27 years). Age at diagnosis and duration of follow-up did not correlate with overall QOL or health-related QOL. Seventy-seven percent rated their overall QOL as outstanding, very good, or good. The key domains affected by cancer were appearance, mood, saliva, and shoulder function. Radiotherapy significantly adversely affected the QOL. The median MDADI scores on all 4 subscales were at least 85%. Higher T-stage and radiotherapy were significantly associated with lower scores on all subscales. Conclusions: The long-term health-related QOL in this cohort was quite good. Radiotherapy and tumor stage correlated with swallowing outcomes, and only radiotherapy seemed to adversely affect the overall QOL. C1 [Thomas, Ligy; Moore, Eric J.; Olsen, Kerry D.; Kasperbauer, Jan L.] Mayo Clin, Dept Otorhinolaryngol Head & Neck Surg, Rochester, MN 55905 USA. RP Moore, EJ (reprint author), Mayo Clin, Dept Otorhinolaryngol, 200 1st St SW, Rochester, MN 55905 USA. CR Abendstein H, 2005, LARYNGOSCOPE, V115, P2183, DOI 10.1097/01.MLG.0000181507.69620.14 BJORDAL K, 1995, BRIT J CANCER, V71, P592, DOI 10.1038/bjc.1995.115 BJORDAL K, 1994, INT J RADIAT ONCOL, V28, P847 Borggreven PA, 2007, ORAL ONCOL, V43, P1034, DOI 10.1016/j.oraloncology.2006.11.017 Chen AY, 2001, ARCH OTOLARYNGOL, V127, P870 de Graeff A, 2000, LARYNGOSCOPE, V110, P98, DOI 10.1097/00005537-200001000-00018 Dwivedi RC, 2012, EUR ARCH OTO-RHINO-L, V269, P1233, DOI 10.1007/s00405-011-1756-y Elsheikh MN, 2005, LARYNGOSCOPE, V115, P1636, DOI 10.1097/01.mlg.0000176540.33486.c3 Elsheikh MN, 2008, ORAL ONCOL, V44, P216, DOI 10.1016/j.oraloncology.2007.06.006 Ferlito A, 2009, BRIT J ORAL MAX SURG, V47, P5, DOI 10.1016/j.bjoms.2008.06.001 Gillespie MB, 2005, ARCH OTOLARYNGOL, V131, P615, DOI 10.1001/archotol.131.7.615 Hammerlid E, 2001, HEAD NECK-J SCI SPEC, V23, P113, DOI 10.1002/1097-0347(200102)23:2<113::AID-HED1006>3.0.CO;2-W Hassanein KAAM, 2001, BRIT J ORAL MAX SURG, V39, P340, DOI 10.1054/bjom.2001.0652 Karnell MP, 2007, J VOICE, V21, P576, DOI 10.1016/j.jvoice.2006.05.001 Kazi R, 2008, ORL J OTO-RHINO-LARY, V70, P151, DOI 10.1159/000124287 Klug C, 2002, INT J ORAL MAX SURG, V31, P664, DOI 10.1054/ijom.2002.0301 Mehanna HM, 2006, CLIN OTOLARYNGOL, V31, P204, DOI 10.1111/j.1749-4486.2006.01188.x Mlynarek AM, 2008, J OTOLARYNGOL-HEAD N, V37, P2, DOI 10.2310/7070.2008.1001 Morton RP, 2003, LARYNGOSCOPE, V113, P1091, DOI 10.1097/00005537-200307000-00001 Mowry SE, 2006, OTOLARYNG HEAD NECK, V135, P565, DOI 10.1016/j.otohns.2006.06.1266 Nordgren M, 2008, HEAD NECK-J SCI SPEC, V30, P461, DOI 10.1002/hed.20735 Pauloski BR, 2002, HEAD NECK-J SCI SPEC, V24, P555, DOI 10.1002/hed.10092 Rogers SN, 1999, INT J ORAL MAX SURG, V28, P99, DOI 10.1034/j.1399-0020.1999.282280204.x Rogers SN, 2002, HEAD NECK-J SCI SPEC, V24, P521, DOI 10.1002/hed.10106 Rogers SN, 2006, INT J ORAL MAX SURG, V35, P913, DOI 10.1016/j.ijorn.2006.07.017 Schache AG, 2009, ORAL ONCOL, V45, P803, DOI 10.1016/j.oraloncology.2008.12.010 Schliephake H, 2002, INT J ORAL MAX SURG, V31, P427, DOI 10.1054/ijom.2001.0194 Silverman DA, 2003, ARCH OTOLARYNGOL, V129, P724, DOI 10.1001/archotol.129.7.724 Thomas L, 2009, CLIN OTOLARYNGOL, V34, P34, DOI 10.1111/j.1749-4486.2008.01830.x Thomas L, 2008, EUR ARCH OTO-RHINO-L, V265, pS29, DOI 10.1007/s00405-007-0470-2 Torres-Carranza Eusebio, 2008, Med Oral Patol Oral Cir Bucal, V13, pE735 Wijers OB, 2002, HEAD NECK-J SCI SPEC, V24, P737, DOI 10.1002/hed.10129 Zhen Y, 2012, EUR J ONCOL NURS, V16, P54, DOI 10.1016/j.ejon.2011.03.002 NR 33 TC 9 Z9 9 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD JUN PY 2012 VL 121 IS 6 BP 395 EP 401 PG 7 WC Otorhinolaryngology SC Otorhinolaryngology GA 958AF UT WOS:000305207500006 PM 22737962 ER PT J AU Hoekzema, CR Massey, BL Blumin, JH Hunt, BC Bock, JM AF Hoekzema, Craig R. Massey, Becky L. Blumin, Joel H. Hunt, Bryan C. Bock, Jonathan M. TI Dysphagia Due to Adenoid Cystic Carcinoma of the Base of the Tongue SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE adenoid cystic carcinoma; base of tongue; dysphagia; head and neck cancer; radiation; surgery ID FACTORS INFLUENCING SURVIVAL; NECK; HEAD AB Objectives: Although oropharyngeal neoplasia can often lead to dysphagia, salivary gland tumors rarely grow within the tongue base. We present the case of a 75-year-old man with adenoid cystic carcinoma of the base of the tongue causing profound dysphagia and weight loss, and provide a current literature review and update on the management of these rare tumors. Methods: We present a case report and a literature review. Results: Physical examination performed at the initial visit revealed a firm right base-of-tongue mass with no palpable lymphadenopathy. Flexible fiberoptic laryngoscopy confirmed a large submucosal mass at the right base of the tongue that obscured the right vallecula. Histopathologic analysis of the operative biopsy specimens revealed the classic features of adenoid cystic carcinoma. Treatment included radical pharyngotomy with wide local excision and primary closure, followed by postoperative radiation treatment. Conclusions: We demonstrate the clinical examination findings and histopathologic characteristics of this disease, and review the literature for clinical treatment recommendations for this rare cause of dysphagia. C1 [Hoekzema, Craig R.; Massey, Becky L.; Blumin, Joel H.; Bock, Jonathan M.] Med Coll Wisconsin, Dept Otolaryngol & Commun Sci, Milwaukee, WI 53226 USA. [Hunt, Bryan C.] Med Coll Wisconsin, Dept Pathol, Milwaukee, WI 53226 USA. RP Bock, JM (reprint author), 9200 W Wisconsin Ave, Milwaukee, WI 53226 USA. EM jbock@mcw.edu CR Bradley Patrick J, 2004, Curr Opin Otolaryngol Head Neck Surg, V12, P127, DOI 10.1097/00020840-200404000-00013 Carrasco Ortiz D, 2006, MED ORAL PATOL ORAL, V11, pE417 GOEPFERT H, 1976, ARCH OTOLARYNGOL, V102, P391 Huang MX, 1997, INT J ORAL MAX SURG, V26, P435, DOI 10.1016/S0901-5027(97)80008-2 KIM KH, 1994, ARCH OTOLARYNGOL, V120, P721 MATSUBA HM, 1986, HEAD NECK-J SCI SPEC, V8, P200, DOI 10.1002/hed.2890080312 Namazie A, 2001, ANN OTO RHINOL LARYN, V110, P248 Silverman DA, 2004, LARYNGOSCOPE, V114, P1194, DOI 10.1097/00005537-200407000-00012 SPIRO RH, 1974, AM J SURG, V128, P512, DOI 10.1016/0002-9610(74)90265-7 SPIRO RH, 1979, AM J SURG, V138, P579, DOI 10.1016/0002-9610(79)90423-9 NR 10 TC 0 Z9 1 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD JUN PY 2012 VL 121 IS 6 BP 402 EP 406 PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA 958AF UT WOS:000305207500007 PM 22737963 ER PT J AU Topaloglu, I Kocak, I Salturk, Z AF Topaloglu, Ilhan Kocak, Ismail Salturk, Ziya TI Multidimensional Evaluation of Vocal Function After Supracricoid Laryngectomy With Cricohyoidopexy SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE arytenoid resection; cricohyoidopexy; supracricoid laryngectomy; voice analysis ID VOICE; SPEECH; CRICOHYOIDOEPIGLOTTOPEXY; OUTCOMES AB Objectives: The aim of this study was to assess the vocal outcome and the impact of arytenoid resection on vocal function following supracricoid laryngectomy with cricohyoidopexy. Methods: Twenty-eight male patients who had undergone supracricoid laryngectomy with cricohyoidopexy were included in the study. In 7 patients, one arytenoid cartilage had been totally resected; in 11, both arytenoid cartilages had been preserved; and in 10, one arytenoid cartilage had been partially resected. The maximum phonation time, fundamental frequency, jitter, shimmer, and noise-to-harmonics ratio were assessed and analyzed. Perceptual analysis was performed with the grade, roughness, breathiness, asthenia, and strain (GRBAS) scale. Abduction-adduction and anteroposterior squeezing actions were analyzed from videoendoscopic records. The Voice Handicap Index-10 (VHI- 10) was used for self-assessment. Results: The acoustic and aerodynamic parameters and GRBAS score showed severe impairment. The self-assessment revealed that patients were relatively satisfied with their voice quality. There were no statistically significant differences in the acoustic and aerodynamic parameters, the GRBAS score, or the VHI-10 score according to the level of arytenoid resection. Conclusions: Supracricoid laryngectomy with cricohyoidopexy caused deterioration of acoustic and aerodynamic voice parameters and the GRBAS score. Statistically, the level of arytenoid resection had no apparent effect on the objective, perceptual, or subjective voice parameters. C1 [Topaloglu, Ilhan; Salturk, Ziya] Istanbul Okmeydani Training & Res Hosp, Dept Otorhinolaryngol Head & Neck Surg, Istanbul, Turkey. RP Topaloglu, I (reprint author), Engin Sitesi Yolu Emek Apt 1-B D 5 34340 1 Levent, Istanbul, Turkey. CR Bron L, 2002, LARYNGOSCOPE, V112, P1289, DOI 10.1097/00005537-200207000-00027 de Vincentiis M, 1998, HEAD NECK-J SCI SPEC, V20, P504, DOI 10.1002/(SICI)1097-0347(199809)20:6<504::AID-HED3>3.0.CO;2-T Dworkin JP, 2003, OTOLARYNG HEAD NECK, V129, P311, DOI 10.1016/S0194-5998(03)01314-7 Göksel Abdullah Onur, 2009, Kulak Burun Bogaz Ihtis Derg, V19, P253 HORII Y, 1982, J SPEECH HEAR RES, V25, P12 Kiliç Mehmet Akif, 2008, Kulak Burun Bogaz Ihtis Derg, V18, P139 LACCOURREYE O, 1995, ANN OTO RHINOL LARYN, V104, P516 Makeieff M, 2005, LARYNGOSCOPE, V115, P546, DOI 10.1097/01.mlg.0000157848.78530.ee Makeieff M, 2007, J VOICE, V21, P508, DOI 10.1016/j.jvoice.2006.03.001 Marioni G, 2004, AM J OTOLARYNG, V25, P98, DOI 10.1016/j.amjoto.2003.11.008 Pastore A, 1998, EUR ARCH OTO-RHINO-L, V255, P371, DOI 10.1007/s004050050080 Pellini R, 2006, ARCH OTOLARYNGOL, V132, P1221, DOI 10.1001/archotol.132.11.1221 Raphael LJ, 2007, SPEECH SCI PRIMER PH, P85 Rosen CA, 2004, LARYNGOSCOPE, V114, P1549, DOI 10.1097/00005537-200409000-00009 Saito K, 2009, OTOLARYNG HEAD NECK, V140, P487, DOI 10.1016/j.otohns.2008.12.036 Schindler A, 2006, AM J OTOLARYNG, V27, P378, DOI 10.1016/j.amjoto.2006.01.010 So YK, 2009, OTOLARYNG HEAD NECK, V141, P770, DOI 10.1016/j.otohns.2009.08.028 Torrejano G, 2009, J VOICE, V23, P240, DOI 10.1016/j.jvoice.2007.08.005 Webster KT, 2010, ANN OTO RHINOL LARYN, V119, P10 Weinstein GS, 2002, ANN OTO RHINOL LARYN, V111, P1 Yuce I, 2009, OTOLARYNG HEAD NECK, V141, P272, DOI 10.1016/j.otohns.2009.04.012 Yuceturk AV, 2004, J LARYNGOL OTOL, V118, P791 Zacharek MA, 2001, LARYNGOSCOPE, V111, P1558, DOI 10.1097/00005537-200109000-00012 NR 23 TC 0 Z9 0 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD JUN PY 2012 VL 121 IS 6 BP 407 EP 412 PG 6 WC Otorhinolaryngology SC Otorhinolaryngology GA 958AF UT WOS:000305207500008 PM 22737964 ER PT J AU Fujio, H Doi, K Hasegawa, S Kobayakawa, T Nibu, K AF Fujio, Hisami Doi, Kiyoshi Hasegawa, Shingo Kobayakawa, Tatsu Nibu, Ken-ichi TI Evaluation of Card-Type Odor Identification Test for Japanese Patients With Olfactory Disturbance SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE Alinamin test; card-type odor identification test; olfaction; Open Essence; visual analog scale AB Objectives: A card-type odor identification test, Open Essence (OE), was recently developed in order to examine olfactory function in the Japanese population. The purpose of this study was to validate the efficacy of this new test by comparison with established olfactory examinations. Methods: We administered Jet Stream Olfactometry (JSO), an intravenous olfaction test (Alinamin test), a visual analog scale of symptoms of olfactory dysfunction, and the OE test to 50 patients with complaints of olfactory disturbance and 50 healthy volunteers. After comparison of the OE test results with those of existing olfactory examinations and the symptom scores, we tried to estimate a cutoff value compatible with the JSO threshold. Results: The scores on the OE test showed significant correlations with the average detection thresholds of JSO (r = -0.738; p <0.0001), the average recognition thresholds of JSO (r = -0.708; p <0.0001), the symptom scores (r = 0.827; p <0.0001), and the duration scores of the intravenous olfactory test (r = 0.673; p <0.0001). The area under the receiver operating characteristics curve between the OE test results and the average recognition thresholds of JSO was highest when the OE test's cutoff value was set at 8. Conclusions: The OE test proved to be a useful tool for screening olfactory disturbance in the Japanese population. Scores of 8 or higher on the OE test should be judged as normal for screening. C1 [Fujio, Hisami] Kobe Univ, Grad Sch Med, Dept Otolaryngol Head & Neck Surg, Chuo Ku, Kobe, Hyogo 6500017, Japan. [Kobayakawa, Tatsu] Natl Inst Adv Ind Sci & Technol, Tsukuba, Ibaraki, Japan. RP Fujio, H (reprint author), Kobe Univ, Grad Sch Med, Dept Otolaryngol Head & Neck Surg, Chuo Ku, 7-5-2 Kusunoki Cho, Kobe, Hyogo 6500017, Japan. FU Japan Society for the Promotion of Science [00379380, 18390458] FX From the Department of Otolaryngology Head and Neck Surgery, Kobe University Graduate School of Medicine, Kobe (Fujio, Doi, Hasegawa, Nibu), and the National Institute of Advanced Industrial Science and Technology, Tsukuba (Kobayakawa), Japan. Supported by Grants-in-Aid for Scientific Research from the Japan Society for the Promotion of Science (00379380 to Dr Doi and 18390458 to Dr Nibu). CR Doty RL, 1996, LARYNGOSCOPE, V106, P353, DOI 10.1097/00005537-199603000-00021 DOTY RL, 1984, LARYNGOSCOPE, V94, P176, DOI 10.1288/00005537-198402000-00004 Fischer JE, 2003, INTENS CARE MED, V29, P1043, DOI 10.1007/s00134-003-1761-8 FURUKAWA M, 1988, Auris Nasus Larynx, V15, P25 Hashimoto Y, 2004, CHEM SENSES, V29, P565, DOI 10.1093/chemse/bjh061 Ikeda K, 1999, Auris Nasus Larynx, V26, P435, DOI 10.1016/S0385-8146(99)00023-1 Kobal G., 1996, Rhinology (Utrecht), V34, P222 Kobayashi M, 2008, AURIS NASUS LARYNX, V35, P53, DOI 10.1016/j.anl.2007.04.014 Kobayashi M, 2006, CHEM SENSES, V31, P335, DOI 10.1093/chemse/bjj037 MCCORMACK HM, 1988, PSYCHOL MED, V18, P1007 Miwa Takayoshi, 2008, Nihon Jibiinkoka Gakkai Kaiho, V111, P399 Nishida Kohei, 2010, Nihon Jibiinkoka Gakkai Kaiho, V113, P751 Saito S, 2006, CHEM SENSES, V31, P379, DOI 10.1093/chemse/bjj042 Saito S, 2003, J JPN ASS ODOR ENV, V34, P1 Streiner DL, 2007, CAN J PSYCHIAT, V52, P121 Tuchida A, 2008, NIPPON AJITO NIOIGAK, V15, P523 Wilson RS, 2009, ANN NY ACAD SCI, V1170, P730, DOI 10.1111/j.1749-6632.2009.04013.x ZUSHO H, 1983, Rhinology (Utrecht), V21, P281 NR 18 TC 2 Z9 2 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD JUN PY 2012 VL 121 IS 6 BP 413 EP 418 PG 6 WC Otorhinolaryngology SC Otorhinolaryngology GA 958AF UT WOS:000305207500009 PM 22737965 ER PT J AU Furuta, Y Oridate, N Takeichi, N Fukuda, S Sawa, H AF Furuta, Yasushi Oridate, Nobuhiko Takeichi, Norihito Fukuda, Satoshi Sawa, Hirofumi TI Alpha-Defensin Overexpression in Patients With Bell's Palsy and Ramsay Hunt Syndrome SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE alpha-defensin; Bell's palsy; Ramsay Hunt syndrome; varicella-zoster virus ID HERPES-SIMPLEX-VIRUS; FACIAL PALSY; DNA AB Objectives: To investigate the biological factors related to the onset of Bell's palsy, we sought to identify differentially expressed genes in peripheral blood mononuclear cells (PBMCs) and plasma of patients with Bell's palsy and Ramsay Hunt syndrome (RHS). Methods: We carried out DNA microarray analyses using PBMCs taken from patients with Bell's palsy at their initial visit and 2 to 4 weeks later. To validate these analyses, we measured the relative messenger RNA levels of alpha-defensin in paired PBMCs by reverse transcription-polymerase chain reaction. The plasma concentrations of alpha-defensin in patients and healthy volunteers were quantified by enzyme-linked immunosorbent assay. Results: The DNA microarray analysis identified alpha-defensin as a candidate gene related to the onset of Bell's palsy. Reverse transcription polymerase chain reaction analysis showed that the relative alpha-defensin messenger RNA levels in PBMCs from the later visit were increased at least twofold in 9 of 13 patients (69%) with Bell's palsy and in 4 of 6 patients (67%) with RHS. The plasma alpha-defensin concentrations in the patients with RHS were significantly higher than those in healthy volunteers (p = 0.0013) and in the patients with Bell's palsy (p = 0.0306). Elevations of plasma alpha-defensin were observed in 5 of the 9 patients with Bell's palsy who demonstrated alpha-defensin overexpression in PBMCs. Conclusions: alpha-Defensin may be one of the biological factors related to the onset of Bell's palsy and RHS. C1 [Furuta, Yasushi; Oridate, Nobuhiko; Takeichi, Norihito; Fukuda, Satoshi] Hokkaido Univ, Grad Sch Med, Dept Otolaryngol Head & Neck Surg, Sapporo, Hokkaido, Japan. [Sawa, Hirofumi] Hokkaido Univ, Dept Mol Pathobiol, Res Ctr Zoonosis Control, Global COE Program Zoonosis Control, Sapporo, Hokkaido, Japan. RP Furuta, Y (reprint author), Teine Keijinkai Hosp, Dept Otolaryngol Head & Neck Surg, Teine Ku, 1-12 Maeda, Sapporo, Hokkaido 0068555, Japan. RI Sawa, Hirofumi/F-6954-2012; Oridate, Nobuhiko/G-5365-2012 FU Ministry of Education, Science, Sports, and Culture, Japan FX From the Department of Otolaryngology Head and Neck Surgery, Hokkaido University Graduate School of Medicine (Furuta, Oridate, Takeichi, Fukuda), and the Department of Molecular Pathobiology, Research Center for Zoonosis Control, Global COE Program for Zoonosis Control, Hokkaido University (Sawa), Sapporo, Japan. This investigation was supported by a Grant-in-Aid for Scientific Research, Ministry of Education, Science, Sports, and Culture, Japan. CR Baringer JR, 1996, ANN INTERN MED, V124, P63 DAHER KA, 1986, J VIROL, V60, P1068 Furuta Y, 1997, J MED VIROL, V52, P316, DOI 10.1002/(SICI)1096-9071(199707)52:3<316::AID-JMV13>3.3.CO;2-6 Guani-Guerra E, 2010, CLIN IMMUNOL, V135, P1, DOI 10.1016/j.clim.2009.12.004 Klotman ME, 2006, NAT REV IMMUNOL, V6, P447, DOI 10.1038/nri1860 MORGAN M, 1992, CLIN INFECT DIS, V14, P263 Murakami S, 1996, ANN INTERN MED, V124, P27 NAKASHIMA H, 1993, AIDS, V7, P1129, DOI 10.1097/00002030-199308000-00019 Sinha S, 2003, ANTIMICROB AGENTS CH, V47, P494, DOI 10.1128/AAC.47.2.494-500.2003 STHOEGER ZM, 2008, IMMUNOLOGY, V127, P116 VAHLNE A, 1981, ARCH OTOLARYNGOL, V107, P79 Yamaguchi N, 2009, INFLAMM RES, V58, P192, DOI 10.1007/s00011-008-8120-8 NR 12 TC 0 Z9 0 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD JUN PY 2012 VL 121 IS 6 BP 419 EP 425 PG 7 WC Otorhinolaryngology SC Otorhinolaryngology GA 958AF UT WOS:000305207500010 PM 22737966 ER PT J AU Patron, V Hitier, M Bedfert, C Le Clech, G Jegoux, F AF Patron, Vincent Hitier, Martin Bedfert, Cecile Le Clech, Guy Jegoux, Franck TI Occult Lymph Node Metastases Increase Locoregional Recurrence in Differentiated Thyroid Carcinoma SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE N0 neck; neck dissection; papillary carcinoma; predictive factor; thyroid neoplasm ID RADICAL-NECK-DISSECTION; PAPILLARY CARCINOMA; DISTANT METASTASES; CANCER; PATTERN; MICROCARCINOMAS; MANAGEMENT; IMPACT AB Objectives: The impact of occult lymph node metastasis (OLNM) on locoregional recurrence (LRR) and survival in patients with N0 differentiated thyroid carcinoma is unclear, because no large study has been carried out. A retrospective study was conducted in our department to assess the influence of OLNM. Methods: We included 201 patients treated by prophylactic neck dissection for NO differentiated thyroid carcinoma between 1974 and 2006. The incidence of OLNM and predictive factors for recurrence and survival were assessed. Results: The incidence of OLNM was 20%. Necks were involved at levels VI, III, II, IV, V, and I, in decreasing order of frequency. After a mean follow-up of 9 years, the rate of LRR was 8.9% and the rate of distant metastasis was 3.4%. An age of greater than 55 years and the presence of OLNM were predictive factors for LRR. An age of greater than 55 years and the presence of LRR were predictive factors for distant metastasis. The presence of distant metastasis was the only factor that significantly and independently influenced the disease-specific survival. Conclusions: We found that OLNM occurred in only 20% of N0 patients. The presence and especially the number of OLNMs on neck dissection were major risk factors for LRR in this study, but did not affect the disease-specific survival. C1 [Patron, Vincent; Hitier, Martin] Caen Univ Hosp, Dept Head & Neck Surg, F-14000 Caen, France. [Patron, Vincent; Bedfert, Cecile; Le Clech, Guy; Jegoux, Franck] Rennes Univ Hosp, Dept Head & Neck Surg, Rennes, France. RP Patron, V (reprint author), Caen Univ Hosp, Dept Head & Neck Surg, Ave Cote de Nacre, F-14000 Caen, France. EM vtromps@yahoo.fr RI Hitier, Martin/E-5915-2013; jegoux, franck/P-6231-2014 CR Cooper DS, 2010, THYROID, V20, P674, DOI 10.1089/thy.2009.0110.cxn ATTIE JN, 1971, AM J SURG, V122, P464, DOI 10.1016/0002-9610(71)90469-7 Bardet S, 2008, EUR J ENDOCRINOL, V158, P551, DOI 10.1530/EJE-07-0603 Bhattacharyya N, 2003, OTOLARYNG HEAD NECK, V128, P115, DOI 10.1067/mhn.2003.2 Bhattacharyya N, 2003, ARCH OTOLARYNGOL, V129, P1101, DOI 10.1001/archotol.129.10.1101 Cheng PT, 2000, ANN OTO RHINOL LARYN, V109, P761 Clark JR, 2005, LARYNGOSCOPE, V115, P661, DOI 10.1097/01.mlg.0000161337.46892.e0 Cooper DS, 2009, THYROID, V19, P1167, DOI 10.1089/thy.2009.0110 Cooper DS, 2010, THYROID, V20, P942, DOI 10.1089/thy.2009.0110.cxn2 Dijkstra PU, 2001, HEAD NECK-J SCI SPEC, V23, P947, DOI 10.1002/hed.1137 Gemsenjager E, 2003, J AM COLL SURGEONS, V197, P182, DOI 10.1016/S1072-7515(03)00421-6 Haymart MR, 2009, ONCOLOGIST, V14, P216, DOI 10.1634/theoncologist.2008-0194 Hughes CJ, 1996, HEAD NECK-J SCI SPEC, V18, P127, DOI 10.1002/(SICI)1097-0347(199603/04)18:2<127::AID-HED3>3.0.CO;2-3 Ito Y, 2004, WORLD J SURG, V28, P498, DOI 10.1007/s00268-004-7192-z Ito Y, 2005, ONCOLOGY-BASEL, V68, P87, DOI 10.1159/000085701 Ito Y, 2007, WORLD J SURG, V31, P2085, DOI 10.1007/s00268-007-9224-y Kupferman ME, 2004, ARCH OTOLARYNGOL, V130, P857, DOI 10.1001/archotol.130.7.857 Kupferman ME, 2004, LARYNGOSCOPE, V114, P403, DOI 10.1097/00005537-200403000-00002 Leboulleux S, 2005, J CLIN ENDOCR METAB, V90, P5723, DOI 10.1210/jc.2005-0285 Mann B, 1998, LANGENBECK ARCH SURG, V383, P355, DOI 10.1007/s004230050148 Noguchi S, 1998, ARCH SURG-CHICAGO, V133, P276, DOI 10.1001/archsurg.133.3.276 NOGUCHI S, 1970, CANCER, V26, P1053, DOI 10.1002/1097-0142(197011)26:5<1053::AID-CNCR2820260513>3.0.CO;2-X Pacini F, 2006, EUR J ENDOCRINOL, V154, P787, DOI 10.1530/eje.1.02158 SCHEUMANN GFW, 1994, WORLD J SURG, V18, P559 SIMPSON WJ, 1988, INT J RADIAT ONCOL, V14, P1063 Sivanandan R, 2001, BRIT J SURG, V88, P1241, DOI 10.1046/j.0007-1323.2001.01843.x Sugitani I, 2008, SURGERY, V143, P35, DOI 10.1016/j.surg.2007.06.011 Wada N, 2003, ANN SURG, V237, P399, DOI 10.1097/00000658-200303000-00015 White M L, 2007, Minerva Chir, V62, P383 NR 29 TC 4 Z9 5 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD MAY PY 2012 VL 121 IS 5 BP 283 EP 290 PG 8 WC Otorhinolaryngology SC Otorhinolaryngology GA 946FE UT WOS:000304336100001 PM 22724272 ER PT J AU Banks, CA Meier, JD Stallworth, CR White, DR AF Banks, Caroline A. Meier, Jeremy D. Stallworth, Christina R. White, David R. TI Recurrent Posttransplant Lymphoproliferative Disorder Involving the Larynx and Trachea: Case Report and Review of the Literature SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article; Proceedings Paper CT Meeting of the American-Broncho-Esophagological-Association CY APR 27-28, 2011 CL Chicago, IL SP Amer Broncho Esophagol Assoc DE Epstein-Barr virus; lymphoproliferative disorder; stridor; transplantation ID TRANSPLANTATION; DISEASE; CHILDREN; MANIFESTATIONS; EXPERIENCE; MANAGEMENT AB Objectives: Posttransplant lymphoproliferative disorder (PTLD) is a well-recognized complication of solid organ transplantation and commonly affects upper airway lymphoid tissue. Tracheal and laryngeal involvement in patients with PTLD, however, is rare. We present one such case. Methods: We report the case of a patient with recurrent PTLD involving the larynx and trachea and describe the presentation, evaluation, management, and outcome. Results: An 11-year-old boy who underwent bilateral nephrectomy and renal transplantation as an infant was admitted to the hospital with chronic cough, fever, stridor, and dyspnea. His post-transplantation course was complicated by PTLD in cervical lymph nodes at 9 years of age that was successfully treated with chemotherapy. A computed tomographic scan during his present admission revealed supraglottic swelling, a distal tracheal mass, and paratracheal lymph node enlargement. The patient underwent laryngoscopy and bronchoscopy with biopsy specimens taken from the right laryngeal ventricle and distal trachea. Pathologic examination yielded a diagnosis of Epstein-Barr virus-positive PTLD. The patient was treated with chemotherapy, which resulted in resolution of the airway lesions, as seen on repeat bronchoscopy. Conclusions: This is the first report, to our knowledge, of recurrent PTLD involving simultaneous lesions in the larynx and the trachea. PTLD in the head and neck can present as lymphoid hypertrophy, airway obstruction, stridor, or cough. A high degree of clinical suspicion is essential for prompt diagnosis of this life-threatening complication. C1 [Banks, Caroline A.; Meier, Jeremy D.; Stallworth, Christina R.; White, David R.] Med Univ S Carolina, Dept Otolaryngol Head & Neck Surg, Charleston, SC 29425 USA. RP Banks, CA (reprint author), Med Univ S Carolina, Dept Otolaryngol Head & Neck Surg, 135 Rutledge Ave,MSC 550, Charleston, SC 29425 USA. CR Abe T, 2010, INT J UROL, V17, P48, DOI 10.1111/j.1442-2042.2009.02405.x CHEN JM, 1993, ANN THORAC SURG, V56, P527 Gonzalez-Cuyar LF, 2007, DIAGN PATHOL, V2, DOI 10.1186/1746-1596-2-49 Hammer GB, 1998, ANESTHESIOLOGY, V89, P263, DOI 10.1097/00000542-199807000-00036 Harris NL, 1997, SEMIN DIAGN PATHOL, V14, P8 HO M, 1988, TRANSPLANTATION, V45, P719, DOI 10.1097/00007890-198804000-00011 Jain A, 2002, ANN SURG, V236, P429, DOI 10.1097/01.SLA.0000033429.89429.89424.F8 Johnson J, 2007, PEDIATR TRANSPLANT, V11, P340, DOI 10.1111/j.1399-3046.2007.00694.x Lattyak BV, 1998, LARYNGOSCOPE, V108, P1195, DOI 10.1097/00005537-199808000-00018 Lewin K J, 1997, Pathol Oncol Res, V3, P177, DOI 10.1007/BF02899918 MArquez US, 2009, REV MED CHILE, V137, P405 Pickhardt PJ, 2000, RADIOLOGY, V217, P16 Rafferty MA, 2000, INT J PEDIATR OTORHI, V54, P149, DOI 10.1016/S0165-5876(00)00340-2 Raut A, 2000, ORAL SURG ORAL MED O, V90, P436, DOI 10.1067/moe.2000.107446 Reyes J, 1996, TRANSPLANT P, V28, P2768 Rombaux P, 2005, B-ENT, V1, P53 Rosbe KW, 2000, ARCH OTOLARYNGOL, V126, P1157 SCULERATI N, 1990, ANN OTO RHINOL LARYN, V99, P445 Shilon Y, 2006, ISRAEL MED ASSOC J, V8, P215 SWINNEN LJ, 1990, NEW ENGL J MED, V323, P1723, DOI 10.1056/NEJM199012203232502 NR 20 TC 0 Z9 0 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD MAY PY 2012 VL 121 IS 5 BP 291 EP 295 PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA 946FE UT WOS:000304336100002 PM 22724273 ER PT J AU Gallego, L Junquera, L Calvo, N Fuente, E Rosado, P AF Gallego, Lorena Junquera, Luis Calvo, Nicolas Fuente, Eduardo Rosado, Pablo TI Bilateral Carcinoma In Situ of Wharton's Duct After Chronic Obstructive Sialadenitis: Inflammation as the Cause of Malignancy? SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE obstructive sialadenitis; squamous cell carcinoma; submandibular gland; Wharton's duct ID SQUAMOUS-CELL CARCINOMA; STENSENS DUCT; EXPRESSION; KI-67 AB A case of bilateral carcinoma in situ of Wharton's duct after chronic sialadenitis is reported. The patient, a 54-year-old man, complained of recurrent pain and swelling in the left lower submandibular region. Computed tomography showed large stones in the hilar area of both submandibular glands. The patient underwent bilateral submandibular excision. Histologic and immunohistochemical examination revealed squamous metaplasia with areas of carcinoma in situ in both right and left ducts adjacent to the calculus. To the best of our knowledge, this is the first case report in the literature describing an association between obstructive sialadenitis and carcinoma in situ of Wharton's duct. We discuss etiologic factors and chronic inflammation as a possible cause of malignancy. C1 [Gallego, Lorena; Calvo, Nicolas; Rosado, Pablo] Cabuenes Hosp, Dept Oral & Maxillofacial Surg, Gijon 33394, Spain. [Fuente, Eduardo] Cabuenes Hosp, Dept Pathol, Gijon 33394, Spain. [Junquera, Luis] Univ Oviedo, Sch Dent, Oviedo, Spain. [Junquera, Luis] Cent Univ Hosp, Dept Oral & Maxillofacial Surg, Oviedo, Spain. RP Gallego, L (reprint author), Cabuenes Hosp, Dept Oral & Maxillofacial Surg, C Prados 395, Gijon 33394, Spain. CR Angiero F, 2008, ANTICANCER RES, V28, P2535 Ellis GL, 1996, ATLAS TUMOR PATHOL, P251 Goforth JL, 1927, AM J MED SCI, V173, P624, DOI 10.1097/00000441-192705000-00004 Kawanishi S, 2006, BIOL CHEM, V387, P365, DOI 10.1515/BC.2006.049 Kim TB, 2009, HEAD NECK-J SCI SPEC, V31, P278, DOI 10.1002/hed.20889 LYALL D, 1954, ANN SURG, V139, P364, DOI 10.1097/00000658-195403000-00015 Maisel B, 1959, AMA ARCH SURG, V78, P331 O'Byrne KJ, 2001, BRIT J CANCER, V85, P473, DOI 10.1054/bjoc.2001.1943 OWENS OT, 1982, OTOLARYNG HEAD NECK, V90, P671 PERACCHIO R L, 1958, Oral Surg Oral Med Oral Pathol, V11, P123, DOI 10.1016/0030-4220(58)90050-1 Preuss SF, 2007, J ORAL MAXIL SURG, V65, P953, DOI 10.1016/j.joms.2006.02.036 Steiner M, 1999, ORAL SURG ORAL MED O, V87, P73, DOI 10.1016/S1079-2104(99)70298-2 Takeda T, 2006, J ORAL PATHOL MED, V35, P369, DOI 10.1111/j.1600-0714.2006.00444.x Tominaga Yukiko, 2006, Radiat Med, V24, P639, DOI 10.1007/s11604-006-0078-2 TRIOLO VA, 1965, CANCER RES, V25, P75 Vigorita VJ, 1980, HEAD NECK SURG, V2, P513 Wakoh M, 2008, ORAL SURG ORAL MED O, V106, pE27, DOI 10.1016/j.tripleo.2008.08.001 NR 17 TC 1 Z9 1 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD MAY PY 2012 VL 121 IS 5 BP 296 EP 300 PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA 946FE UT WOS:000304336100003 PM 22724274 ER PT J AU Zeitels, SM Wain, JC Barbu, AM Bryson, PC Burns, JA AF Zeitels, Steven M. Wain, John C. Barbu, Anca M. Bryson, Paul C. Burns, James A. TI Aortic Homograft Reconstruction of Partial Laryngectomy Defects: A New Technique SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article; Proceedings Paper CT Meeting of the American-Broncho-Esophagological-Association CY APR 18-19, 2012 CL San Diego, CA SP Amer Broncho Esophagol Assoc DE aortic homograft; glottic cancer; larynx cancer; larynx chondrosarcoma; partial laryngectomy; subglottic cancer ID TRACHEAL REPLACEMENT; LASER TREATMENT; SURGERY; CANCER; CARCINOMA; REPAIR AB Objectives: Wide-field transcervical partial laryngectomy often precludes tracheotomy decannulation. It is done infrequently today, primarily because of the popularity of chemotherapy-radiotherapy treatment regimens and limited enthusiasm for using transcervical partial laryngectomy after failed radiotherapy. We sought to identify a new reconstructive technique that would provide an alternative to total laryngectomy in as many patients as possible. Methods: We performed a retrospective examination of 15 patients who underwent single-stage wide-field transcervical partial laryngectomy with cryopreserved aortic homograft reconstruction. Eight of the 15 patients had previously undergone failed radiotherapy. At least 40% of the cricoid circumference was resected in 8 patients. Results: All 15 patients had their tracheotomy tube removed and have laryngeal phonation, and 14 of the 15 resumed oral intake. There were no major surgical complications. Conclusions: Use of aortic homografts is a new, reliable, and versatile reconstructive option for performing conservation laryngeal cancer surgery that allows for airway, swallowing, and voice preservation. C1 [Zeitels, Steven M.; Barbu, Anca M.; Burns, James A.] Massachusetts Gen Hosp, Ctr Laryngeal Surg & Voice Rehabil, Boston, MA 02114 USA. [Zeitels, Steven M.; Wain, John C.; Barbu, Anca M.; Bryson, Paul C.; Burns, James A.] Harvard Univ, Sch Med, Dept Surg, Boston, MA 02115 USA. [Wain, John C.] Massachusetts Gen Hosp, Div Thorac Surg, Boston, MA 02114 USA. RP Zeitels, SM (reprint author), Massachusetts Gen Hosp, Ctr Laryngeal Surg & Voice Rehabil, 1 Bowdoin Sq, Boston, MA 02114 USA. CR ALONSO J M, 1947, Trans Am Acad Ophthalmol Otolaryngol, V51, P633 Azorin JF, 2006, EUR J CARDIO-THORAC, V29, P261, DOI 10.1016/j.ejcts.2005.11.026 Dodge-Khatami A, 2002, J THORAC CARDIOV SUR, V123, P826, DOI 10.1067/mtc.2002.122065 Ehrmann CH, 1850, HIST POLYPS LARYNX Fraenkel B, 1886, ARCH KLIN CHIR, V12, P283 Hoffman HT, 2006, LARYNGOSCOPE, V116, P1, DOI 10.1097/01.mlg.0000236095.97947.26 Jackson C, 1939, CANC LARYNX, P216 JAKO GJ, 1972, LARYNGOSCOPE, V82, P2204, DOI 10.1288/00005537-197212000-00009 LACCOURREYE H, 1987, ANN OTO RHINOL LARYN, V96, P217 LEROUX-ROBERT J, 1956, Ann Otol Rhinol Laryngol, V65, P137 PRESSMAN J J, 1959, Am Surg, V25, P850 PRESSMAN JJ, 1958, SURG GYNECOL OBSTET, V106, P56 PRESSMAN J J, 1953, Trans Annu Meet Am Bronchoesophagol Assoc, V45, P18 Scheppegrell W, 1902, NY MED J, V76, P984 Silver CE, 1981, SURG CANC LARYNX Solis-Cohen J, 1869, MED REC, V4, P244 Steiner W, 1988, Adv Otorhinolaryngol, V39, P135 STRONG MS, 1975, LARYNGOSCOPE, V85, P1286, DOI 10.1288/00005537-197508000-00003 WOLF GT, 1991, NEW ENGL J MED, V324, P1685 VAUGHAN CW, 1978, AM J SURG, V136, P490, DOI 10.1016/0002-9610(78)90267-2 Weinstein GS, 2007, ANN OTO RHINOL LARYN, V116, P19 Wurtz A, 2006, NEW ENGL J MED, V355, P1938, DOI 10.1056/NEJMc066336 Zeitels SM, 2003, NEW ENGL J MED, V349, P882, DOI 10.1056/NEJMra035148 ZEITELS SM, 1990, ANN OTO RHINOL LARYN, V99, P951 Zeitels SM, 2007, ANN OTOL RHINOL S198, V116 Zeitels SM, 2006, ANN OTO RHINOL LARYN, V115, P571 Zeitels SM, 2006, ANN OTO RHINOL LARYN, V115, P679 NR 27 TC 5 Z9 5 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD MAY PY 2012 VL 121 IS 5 BP 301 EP 306 PG 6 WC Otorhinolaryngology SC Otorhinolaryngology GA 946FE UT WOS:000304336100004 PM 22724275 ER PT J AU Bernstein, JM Lehman, H Lis, M Sands, A Wilding, GE Shultz, L Bankert, R Bobek, L AF Bernstein, Joel M. Lehman, Heather Lis, Maciej Sands, Amy Wilding, Gregory E. Shultz, Leonard Bankert, Richard Bobek, Libuse TI Humanized Mouse Model Used to Monitor MUC Gene Expression in Nasal Polyps and to Preclinically Evaluate the Efficacy of Montelukast in Reducing Mucus Production SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE montelukast; mucous gland; nasal polyp; SCID mouse ID CHRONIC HYPERPLASTIC SINUSITIS; EPITHELIAL-CELLS; MICE; EOSINOPHILIA; XENOGRAFTS; GLANDS AB Objectives: To determine whether MUC gene expression could be down-regulated in nasal polyps by the leukotriene receptor antagonist montelukast, we developed a system in which nondisrupted human nasal polyps could be successfully implanted into severely immunocompromised mice, and in which the histopathology of the original nasal polyp tissue could be preserved for long periods. In addition, the histopathologic changes in the human nasal polyps were carefully examined to determine the origin of the submucosal glands (SMGs) that develop in true nasal polyps found in the anterior third of the nose. Methods: Small, nondisrupted pieces of human nasal polyp tissues were subcutaneously implanted into NOD-scid IL-2r gamma(null) mice. Xenograft-bearing mice were treated with either montelukast or saline solution. Xenografts at 8 to 12 weeks after implantation were examined histologically, and expression of MUC genes 4, 5AC, and 7 was studied in the polyps before implantation and in the 8-week xenograft. Alzet pumps were inserted into the mice, and montelukast (Singulair) was continuously delivered to determine its effect on goblet cell hyperplasia, mucus production, and the enlargement of nasal polyps over an 8-week period. Results: The xenografts were maintained in a viable and functional state for up to 3 months and retained a histopathology similar to that of the original tissue, but with a noticeable increase in goblet cell hyperplasia and marked mucus accumulation in the SMGs. MUC4 and MUC5AC were significantly increased in the xenograft 8 weeks after implantation, but MUC7 was significantly decreased compared to the preimplantation polyps. Inasmuch as MUC7 is found exclusively in serous glands, the findings suggest that serous glands are not found in polyps in the anterior third of the nose. The histopathologic findings confirm the original findings of Tos et al suggesting that the SMGs are derived from pinching-off of the epithelium of the enlarging polyp following inflammatory changes. These SMGs have the same epithelium as surface epithelium and consist of multiple goblet cells that secrete periodic acid Schiff-stain positive mucin into the interior of the SMGs. A progressive increase in the volume of the xenografts was observed, with little or no evidence of mouse cell infiltration into the human leukocyte antigen positive human tissue. An average twofold increase in polyp volume was found 2 months after engraftment. Montelukast did not decrease the growth of the xenograft in the 8-week NOD-scid mice, nor did it affect MUC gene expression. Conclusions: The use of innate and adaptive immunodeficient NOD-scid mice homozygous for targeted mutations in the IL-2 gamma-chain locus NOD-scid IL-2r gamma(null) for establishing engraftment of nondisrupted pieces of human nasal polyp tissues represents a significant advancement in studying chronic inflammation over a long period of time. In the present study, we utilized this humanized mouse model to confirm our prediction that MUC genes 4 and SAC are highly expressed and significantly increased over those of preimplanted polyps. The overexpression of these 2 MUC genes correlates with both the goblet cell hyperplasia and the excessive mucus production that are found in nasal polyp xenografts. MUC7, which is primarily associated with the submucosa, as opposed to MUC4 and MUC5AC, which are primarily expressed in the epithelium, was significantly decreased in the nasal polyp xenografts. Montelukast had no significant effect on MUC gene expression in the xenografts. In addition to the MUC gene expression patterns, the histology of the xenografts supports the concept that mucinous glands that are characteristic of true nasal polyps are significantly different from those in the mucosa found in the lateral wall of the nose in patients with chronic sinusitis without nasal polyps. The mucinous glands seen in nasal polyps (which appear to be derived from an invagination of hyperplastic epithelial mucosa containing large numbers of goblet cells) are histologically distinct from the seromucinous glands found in the submucosa of hyperplastic middle turbinates. The data presented here establish a humanized mouse model as a viable approach to study nasal polyp growth, to assess the therapeutic efficacy of various drugs in this chronic inflammatory disease, and to contribute to our understanding of the pathogenesis of this disease. C1 [Bernstein, Joel M.] SUNY Buffalo, Dept Otolaryngol, Sch Med & Biomed Sci, Buffalo, NY 14260 USA. [Bernstein, Joel M.; Lehman, Heather] SUNY Buffalo, Dept Pediat, Sch Med & Biomed Sci, Buffalo, NY 14260 USA. [Sands, Amy] SUNY Buffalo, Dept Pathol, Sch Med & Biomed Sci, Buffalo, NY 14260 USA. [Bankert, Richard] SUNY Buffalo, Dept Microbiol, Sch Med & Biomed Sci, Buffalo, NY 14260 USA. [Lis, Maciej; Bobek, Libuse] SUNY Buffalo, Dept Oral Biol, Sch Dent Med, Buffalo, NY 14260 USA. [Bernstein, Joel M.] SUNY Buffalo, Dept Commun Disorders & Sci, Buffalo, NY 14260 USA. [Wilding, Gregory E.] SUNY Buffalo, Dept Biostat, Buffalo, NY 14260 USA. [Wilding, Gregory E.] Roswell Pk Canc Inst, Dept Biostat, Buffalo, NY 14263 USA. [Shultz, Leonard] Jackson Lab, Buffalo, NY USA. RP Bernstein, JM (reprint author), 2430 N Forest Rd, Getzville, NY 14068 USA. FU US Public Health Service [R01-CA108970, R01-CA131407, R01-CA34196, AI 079188]; Ralph Hoch-stetter Medical Research Fund; Juvenile Diabetes Research Foundation; Merck Co, Inc. FX From the Departments of Otolaryngology (Bernstein), Pediatrics (Bernstein, Lehman), Pathology (Sands), and Microbiology (Bankert), School of Medicine and Biomedical Sciences, the Department of Oral Biology, School of Dental Medicine (Lis, Bobek), the Department of Communicative Disorders and Sciences (Bernstein), and the Department of Biostatistics (Wilding), State University of New York at Buffalo; the Department of Biostatistics, Roswell Park Cancer Institute (Wilding); and The Jackson Laboratory (Shultz); Buffalo, New York. This study was supported in part by US Public Health Service grants R01-CA108970, R01-CA131407, R01-CA34196, and AI 079188, by the Ralph Hoch-stetter Medical Research Fund in honor of Dr Henry C. and Bertha Boswell, by the Juvenile Diabetes Research Foundation, and by a research grant from the Investigator-Initiated Studies Program of Merck & Co, Inc. The opinions expressed in this paper are those of the authors and do not necessarily represent those of Merck & Co, Inc. The study was performed in accordance with the PHS Policy on Humane Care and Use of Laboratory Animals, the NIH Guide for the Care and Use of Laboratory Animals, and the Animal Welfare Act (7 U.S.C. et seq.); the animal use protocol was approved by the Institutional Animal Care and Use Committee (IACUC) of the State University of New York at Buffalo. CR Ali MS, 2005, ACTA OTO-LARYNGOL, V125, P618, DOI 10.1080/00016480510027538 Arango P, 2002, OTOLARYNG HEAD NECK, V127, P512, DOI 10.1067/mhn.2002.129858 Bai CH, 2007, AURIS NASUS LARYNX, V34, P203, DOI 10.1016/j.anl.2006.11.006 Berger G, 2002, LARYNGOSCOPE, V112, P738, DOI 10.1097/00005537-200204000-00026 Bernstein JM, 2006, ANN OTO RHINOL LARYN, V115, P65 Bernstein JM, 1995, OTOLARYNG HEAD NECK, V113, P724, DOI 10.1016/S0194-5998(95)70012-9 Bernstein JM, 2009, LARYNGOSCOPE, V119, P1258, DOI 10.1002/lary.20239 Bernstein JM, 2010, NASAL POLYPOSIS: PATHOGENESIS, MEDICAL AND SURGICAL TREATMENT, P27, DOI 10.1007/978-3-642-11412-0_4 Bernstein JM, 2009, ANN OTO RHINOL LARYN, V118, P866 Bernstein J M, 2001, Curr Allergy Asthma Rep, V1, P262, DOI 10.1007/s11882-001-0017-3 BOBEK LA, 1993, J BIOL CHEM, V268, P20563 Burgel PR, 2000, J ALLERGY CLIN IMMUN, V106, P705, DOI 10.1067/mai.2000.109823 Kim CH, 2000, LARYNGOSCOPE, V110, P2110, DOI 10.1097/00005537-200012000-00026 Li SM, 2006, AM J RESP CELL MOL, V35, P95, DOI 10.1165/rcmb.2005-0305OC Lü Haili, 2004, Lin Chuang Er Bi Yan Hou Ke Za Zhi, V18, P649 Martinez-Anton A, 2006, CLIN EXP ALLERGY, V36, P448, DOI 10.1111/j.1365-2222.2006.02451.x Sala A, 2010, PHARMACOL REP, V62, P503 Sharma P, 1998, AM J RESP CELL MOL, V19, P30 Shultz LD, 2007, NAT REV IMMUNOL, V7, P118, DOI 10.1038/nri2017 Steinke JW, 2003, J ALLERGY CLIN IMMUN, V111, P342, DOI 10.1067/mai.2003.67 Suzuki S, 2008, PHARMACOLOGY, V81, P221, DOI 10.1159/000112866 TOS M, 1977, ARCH OTOLARYNGOL, V103, P407 TOS M, 1977, Rhinology (Utrecht), V15, P87 TOS M, 1990, ANN OTO RHINOL LARYN, V99, P310 Woo HJ, 2010, ARCH OTOLARYNGOL, V136, P603, DOI 10.1001/archoto.2010.71 NR 25 TC 1 Z9 1 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD MAY PY 2012 VL 121 IS 5 BP 307 EP 316 PG 10 WC Otorhinolaryngology SC Otorhinolaryngology GA 946FE UT WOS:000304336100005 PM 22724276 ER PT J AU Young, N Wadie, M Sasaki, CT AF Young, Nwanmegha Wadie, Mikhail Sasaki, Clarence T. TI Neuromuscular Basis for Ventricular Fold Function SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article; Proceedings Paper CT Meeting of the American-Broncho-Esophagological-Association CY APR 27-28, 2011 CL Chicago, IL SP Amer Broncho Esophagol Assoc DE false vocal fold; laryngeal innervation; ventricular fold; vocal fold paralysis ID PHONATION; DYSPHONIA AB Objectives: We sought to examine the neuromuscular basis for ventricular fold function. The primary function of the ventricular folds is to assist in the regulation of intra-abdominal and intrathoracic pressure. They also influence phonation in the setting of vocal fold paralysis or ventricular dysphonia, or after partial laryngectomy. The neuromuscular basis of true vocal fold function has been well studied; however, its neuromuscular correlates in the ventricular folds are ambiguous. The literature is unclear as to whether ventricular fold contraction is passive or active. The musculature and innervation responsible for this action also have not been well defined. The aim of this study was to provide clarity in regard to these mechanisms. Methods: We examined a whole-organ section of a human larynx from a patient with unilateral vocal fold paralysis. The region of the ventricular folds was compared on both the paralyzed and normal sides. Electrophysiological examination was performed in a porcine model. The superior laryngeal nerve was stimulated, and recording electrodes in both ventricular folds measured the electrical activity. The recurrent laryngeal nerve was then severed, and the experiment was repeated. Results: The histologic slides from the patient with unilateral vocal fold paralysis demonstrated atrophied ventricularis and thyroarytenoid muscles on the paralyzed side. On the unaffected side, these muscles were of normal size. The electrophysiological examination in the porcine model demonstrated findings consistent with innervation of the ventricularis muscle by the recurrent laryngeal nerve. An association of ventricularis muscle activity with ventricular fold contraction also was demonstrated. Conclusions: Ventricular fold adduction appears to be a result of ventricularis muscle contraction that is mediated by the recurrent laryngeal nerve. C1 [Young, Nwanmegha; Wadie, Mikhail; Sasaki, Clarence T.] Yale Univ, Sch Med, Dept Surg, Otolaryngol Sect, New Haven, CT 06510 USA. RP Young, N (reprint author), 800 Howard Ave, New Haven, CT 06511 USA. CR ARDRAN GM, 1952, J PHYSIOL-LONDON, V118, pP39 Jackson C, 1935, ARCHIV OTOLARYNGOL, V21, P157 Kelchner LN, 2010, ANN OTO RHINOL LARYN, V119, P383 Kim YH, 2001, ACTA OTO-LARYNGOL, V121, P310 KOTBY MN, 1991, ACTA OTO-LARYNGOL, V111, P396, DOI 10.3109/00016489109137409 Lindestad Per-Ake, 2004, Logoped Phoniatr Vocol, V29, P162, DOI 10.1080/14015430410020339 Pinho SMR, 1999, J VOICE, V13, P36, DOI 10.1016/S0892-1997(99)80059-9 Pressman JJ, 1941, ARCHIV OTOLARYNGOL, V33, P351 RETHI A, 1952, Folia Phoniatr (Basel), V4, P201 Sataloff RT, 1997, PROFESSIONAL VOICE S, P815 VONDOERSTEN PG, 1992, LARYNGOSCOPE, V102, P1296, DOI 10.1288/00005537-199211000-00018 Waxman SG, 1996, CORRELATIVE NEUROANA, P25 Zheng XD, 2009, ANN BIOMED ENG, V37, P625, DOI 10.1007/s10439-008-9630-9 NR 13 TC 1 Z9 1 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD MAY PY 2012 VL 121 IS 5 BP 317 EP 321 PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA 946FE UT WOS:000304336100006 PM 22724277 ER PT J AU Cingi, C Eskiizmir, G Cakli, H AF Cingi, Cemal Eskiizmir, Gorkem Cakli, Hamdi TI Comparative Analysis of Primary and Secondary Rhinoplasties According to Surgeon's Perspective, Patient Satisfaction, and Quality of Life SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE acquired nasal deformity; patient satisfaction; quality of life; reoperation; rhinoplasty; treatment outcome ID FACIAL PLASTIC-SURGERY; REVISION RHINOPLASTY; OUTCOMES RESEARCH; COSMETIC SURGERY AB Objectives: We sought to analyze and compare the problems and technical difficulties related to surgical intervention, patient satisfaction, and quality of life after primary and secondary rhinoplasties. Methods: A total of 168 cases of rhinoplasty were grouped as primary or secondary according to the patient's history of rhinoplasty. The type of nasal deformity, the surgical approach, and the difficulty of the surgery were recorded. The levels of patient satisfaction and the quality of life were assessed before and after the operation with the Rhinoplasty Outcomes Evaluation (ROE) and European Quality of Life-5 Dimension (EQ-5D) questionnaires. A quantitative and statistical analysis was performed. Results: Thirty-three patients had secondary rhinoplasty. and 135 patients had primary rhinoplasty. Relatively high rates of saddle nose deformity, crooked nose, and tip asymmetry were observed in the secondary rhinoplasty group. The preoperative and postoperative scores on the ROE and EQ-5D questionnaires demonstrated statistically significant differences in both the primary and secondary rhinoplasty groups. The comparison of postoperative change between the primary and secondary rhinoplasty groups did not demonstrate a statistically significant difference. Conclusions: The surgical difficulty of secondary rhinoplasty is approximately twice that of primary rhinoplasty because of the high rate of major deformities. However, the levels of patient satisfaction and improvements in quality of life are similar after primary and secondary rhinoplasties. C1 [Cingi, Cemal; Eskiizmir, Gorkem; Cakli, Hamdi] Osmangazi Univ, Dept Otolaryngol Head Neck Surg, Eskisehir, Turkey. RP Eskiizmir, G (reprint author), Celal Bayar Univ, Dept Otolaryngol Head Neck Surg, TR-45010 Manisa, Turkey. CR Acquadro C, 2003, VALUE HEALTH, V6, P522, DOI 10.1046/j.1524-4733.2003.65309.x Alsarraf R, 2001, Arch Facial Plast Surg, V3, P198, DOI 10.1001/archfaci.3.3.198 Alsarraf R, 2000, AESTHET PLAST SURG, V24, P192, DOI 10.1007/s002660010031 AUFRICHT G, 1969, PLAST RECONSTR SURG, V43, P219, DOI 10.1097/00006534-196903000-00001 Baumann I, 2005, AM J RHINOL, V19, P282 Bracaglia R, 2005, AESTHET PLAST SURG, V29, P230, DOI 10.1007/s00266-005-0034-z Ching S, 2003, PLAST RECONSTR SURG, V111, P469, DOI 10.1097/01.PRS.0000036041.67101.48 Chow A, 2009, SURGERY, V146, P435, DOI 10.1016/j.surg.2009.03.019 Converse JM, 1977, RECONSTRUCTIVE PLAST, P1152 COPAS JB, 1989, BRIT J PLAST SURG, V42, P65, DOI 10.1016/S0007-1226(89)90115-X EuroQol Group, 1990, HLTH POLICY, V16, P199, DOI DOI 10.1016/0168-8510(90)90421-9 Farrior E H, 1997, Facial Plast Surg, V13, P299 Graf von der Schulenburg JM, 1998, Z GESUNDHEITSWISSENS, V6, P3 Hellings PW, 2007, LARYNGOSCOPE, V117, P985, DOI 10.1097/MLG.0b013e31804f8152 KAMER FM, 1988, ARCH OTOLARYNGOL, V114, P257 Klassen A, 1999, J EPIDEMIOL COMMUN H, V53, P440 Luce EA, 1999, PLAST RECONSTR SURG, V104, P1187, DOI 10.1097/00006534-199909040-00051 Meningaud JP, 2001, J CRANIO MAXILL SURG, V29, P177, DOI 10.1054/jcms.2001.0213 Meningaud JP, 2008, PLAST RECONSTR SURG, V121, P251, DOI 10.1097/01.prs.0000293866.57517.d4 Park CH, 2009, ARCH OTOLARYNGOL, V135, P146, DOI 10.1001/archoto.2008.522 Rhee JS, 2008, ARCH FACIAL PLAST S, V10, P194, DOI 10.1001/archfaci.10.3.194 Wilkins EG, 1996, ANN PLAS SURG, V37, P1, DOI 10.1097/00000637-199607000-00001 Won TB, 2010, ANN PLAS SURG, V65, P379, DOI 10.1097/SAP.0b013e3181d9ab0e Wright JG, 1999, WORLD J SURG, V23, P1224 Yu K, 2010, ARCH FACIAL PLAST S, V12, P291, DOI 10.1001/archfacial.2010.62 NR 25 TC 3 Z9 3 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD MAY PY 2012 VL 121 IS 5 BP 322 EP 327 PG 6 WC Otorhinolaryngology SC Otorhinolaryngology GA 946FE UT WOS:000304336100007 PM 22724278 ER PT J AU Ping, LC Yuan, M Feng, HH AF Ping, Lichuan Yuan, Meng Feng, Haihong TI Musical Pitch Discrimination by Cochlear Implant Users SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE cochlear implant; musical pitch discrimination; temporal-place pattern of electrical stimulation ID ELECTRIC HEARING; PERCEPTION; SPEECH; RECOGNITION; LISTENERS AB Objectives: The main goal of this study was to investigate the effects of acoustic characteristics, including timbre and fundamental frequency (F0), on the musical pitch discrimination of cochlear implant users. Methods: Eight postlingually deafened cochlear implant users were recruited, along with 8 control subjects with normal hearing. Pitch discrimination tests were carried out using test stimuli from 4 musical instruments plus synthetic complex stimuli. Three reference tones with different F0s were used. Results: The mean difference limens were 1.8 to 10.7 semitones in the just-noticeable difference task and 2.1 to 13.6 semitones in the pitch-direction discrimination task for different timbre and F0 combinations. Three-way analysis of variance showed that the acoustic characteristics of the musical stimuli, such as timbre and F0, significantly influenced pitch discrimination performance. Conclusions: Acoustic characteristics determine the complexity of the electrical stimulation pattern, which directly affects performance in pitch discrimination. A place pattern with a clear and regular low-order harmonic structure is most important for good pitch discrimination. A clear F0-related temporal pattern is also useful when the F0 is low. Pitch perception performance will worsen when there is interference in the high-frequency channels. C1 [Ping, Lichuan; Yuan, Meng; Feng, Haihong] Chinese Acad Sci, Shanghai Acoust Lab, Inst Acoust, Shanghai 200032, Peoples R China. [Yuan, Meng] E China Normal Univ, Key Lab Speech & Hearing Sci, Minist Educ, Shanghai 200062, Peoples R China. [Ping, Lichuan] Chinese Acad Sci, Grad Univ, Shanghai 200032, Peoples R China. RP Yuan, M (reprint author), Chinese Acad Sci, Shanghai Acoust Lab, Inst Acoust, Shanghai 200032, Peoples R China. FU Chinese Academy of Sciences [KGCX2-YX-607]; Key Projects in the National Science and Technology Pillar Program in the Eleventh Five-Year Plan Period [2008BAI50B08]; Key Laboratory of Speech and Hearing Sciences (East China Normal University), Ministry of Education FX From the Shanghai Acoustics Laboratory, Institute of Acoustics, Chinese Academy of Sciences (all authors), and the Key Laboratory of Speech and Hearing Sciences (East China Normal University), Ministry of Education (Yuan), Shanghai, and the Graduate University of Chinese Academy of Sciences, Beijing (Ping), China. This work has been supported in part by the Chinese Academy of Sciences Pilot Project of the Knowledge Innovation Program (KGCX2-YX-607), Key Projects in the National Science and Technology Pillar Program in the Eleventh Five-Year Plan Period (2008BAI50B08), and the Open Research Fund Program of the Key Laboratory of Speech and Hearing Sciences (East China Normal University), Ministry of Education. CR Drennan WR, 2008, J REHABIL RES DEV, V45, P779, DOI 10.1682/JPRD.2007.08.0118 Fearn R. A., 2001, THESIS U NEW S WALES, P135 Firszt JB, 2009, OTOL NEUROTOL, V30, P146, DOI 10.1097/MAO.0b013e3181924ff8 Fujita S, 1999, ANN OTO RHINOL LARYN, V108, P634 Galvin JJ, 2007, EAR HEARING, V28, P302, DOI 10.1097/01.aud.0000261689.35445.20 Gfeller Kate, 2002, Cochlear Implants Int, V3, P29, DOI 10.1002/cii.50 Haumann S, 2007, HNO, V55, P613, DOI 10.1007/s00106-006-1485-5 Kong YY, 2005, J ACOUST SOC AM, V117, P1351, DOI 10.1121/1.1857526 Kong YY, 2006, J ACOUST SOC AM, V120, P2830, DOI 10.1121/1.2346009 Laneau J, 2006, AUDIOL NEURO-OTOL, V11, P38, DOI 10.1159/000088853 Limb Charles J, 2006, Curr Opin Otolaryngol Head Neck Surg, V14, P337, DOI 10.1097/01.moo.0000244192.59184.bd Looi V., 2008, OTORINOLARINGOLOGIA, V58, P169 McDermott Hugh J, 2004, Trends Amplif, V8, P49, DOI 10.1177/108471380400800203 McKay CM, 1996, J ACOUST SOC AM, V100, P1081, DOI 10.1121/1.416294 Moore B. C. J., 2005, PITCH NEURAL CODING, P234 Moore BC., 2003, INTRO PSYCHOL HEARIN Nie KB, 2005, IEEE T BIO-MED ENG, V52, P64, DOI 10.1109/TBME.2004.839799 Nimmons GL, 2008, OTOL NEUROTOL, V29, P149 Nogueira W, 2005, EURASIP J APPL SIG P, V2005, P3044, DOI 10.1155/ASP.2005.3044 Smith ZM, 2002, NATURE, V416, P87, DOI 10.1038/416087a Sucher CM, 2007, HEARING RES, V230, P80, DOI 10.1016/j.heares.2007.05.002 Wilson BS, 2008, HEARING RES, V242, P3, DOI 10.1016/j.heares.2008.06.005 Xu L, 2002, J ACOUST SOC AM, V112, P247, DOI 10.1121/1.1487843 Zeng F G, 2008, IEEE REV BIOMED 0101, P115 Zeng FG, 2002, HEARING RES, V174, P101, DOI 10.1016/S0378-5955(02)00644-5 NR 25 TC 1 Z9 1 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD MAY PY 2012 VL 121 IS 5 BP 328 EP 336 PG 9 WC Otorhinolaryngology SC Otorhinolaryngology GA 946FE UT WOS:000304336100008 PM 22724279 ER PT J AU Mathew, R Asimacopoulos, E Walker, D Gutierrez, T Valentine, P Pitkin, L AF Mathew, Rajeev Asimacopoulos, Eleni Walker, David Gutierrez, Tatiana Valentine, Peter Pitkin, Lisa TI Analysis of Clinical Negligence Claims Following Tonsillectomy in England 1995 to 2010 SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE complication; litigation; malpractice; tonsillectomy ID ADENOIDECTOMY; COMPLICATIONS; HEMORRHAGE AB Objectives: We determined the characteristics of medical negligence claims following tonsillectomy. Methods: Claims relating to tonsillectomy between 1995 and 2010 were obtained from the National Health Service Litigation Authority database. The number of open and closed claims was determined, and data were analyzed for primary injury claimed, outcome of claim, and associated costs. Results: Over 15 years, there were 40 claims of clinical negligence related to tonsillectomy, representing 7.7% of all claims in otolaryngology. There were 34 closed claims, of which 32 (94%) resulted in payment of damages. Postoperative bleeding was the most common injury, with delayed recognition and treatment of bleeding alleged in most cases. Nasopharyngeal regurgitation as a result of soft palate fistulas or excessive tissue resection was the next-commonest cause of a claim. The other injuries claimed included dentoalveolar injury, burns, tonsillar remnants, and temporomandibular joint dysfunction. Inadequate informed consent was claimed in 5 cases. Conclusions: Clinical negligence claims following tonsillectomy have a high success rate. Although postoperative bleeding is the most common cause of negligence claims, a significant proportion of claims are due to rare complications of surgery. Informed consent should be tailored to the individual patient and should include a discussion of common and serious complications. C1 [Mathew, Rajeev; Walker, David; Gutierrez, Tatiana; Valentine, Peter; Pitkin, Lisa] Royal Surrey Cty Hosp, Dept Otolaryngol, Guildford GU2 7XX, Surrey, England. [Asimacopoulos, Eleni] St Marys Hosp, Dept Otolaryngol, London, England. RP Mathew, R (reprint author), Royal Surrey Cty Hosp, Dept Otolaryngol, Guildford GU2 7XX, Surrey, England. CR CRESSMAN WR, 1995, AM J OTOLARYNG, V16, P29, DOI 10.1016/0196-0709(95)90006-3 CRYSDALE WS, 1986, CAN MED ASSOC J, V135, P1139 HAAPANEN ML, 1994, EUR ARCH OTO-RHINO-L, V251, P186 Brown P, 2004, LANCET, V364, P697 Maini S, 2002, CLIN OTOLARYNGOL, V27, P57, DOI 10.1046/j.0307-7772.2001.00528.x Mello MM, 2010, HEALTH AFFAIR, V29, P1569, DOI 10.1377/hlthaff.2009.0807 Mistry D, 2004, CLIN OTOLARYNGOL, V29, P362, DOI 10.1111/j.1365-2273.2004.00818.x Morris LGT, 2008, OTOLARYNG HEAD NECK, V138, P315, DOI 10.1016/j.otohns.2007.11.024 Nuara MJ, 2008, ARCH OTOLARYNGOL, V134, P10, DOI 10.1001/archoto.2007.5 Randall DA, 1998, OTOLARYNG HEAD NECK, V118, P61, DOI 10.1016/S0194-5998(98)70376-6 Simonsen AR, 2010, INT J PEDIATR OTORHI, V74, P977, DOI 10.1016/j.ijporl.2010.05.029 Studdert DM, 2000, MED CARE, V38, P250, DOI 10.1097/00005650-200003000-00002 Windfuhr JP, 2009, EUR ARCH OTO-RHINO-L, V266, P1621, DOI 10.1007/s00405-009-0910-2 NR 13 TC 3 Z9 3 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD MAY PY 2012 VL 121 IS 5 BP 337 EP 340 PG 4 WC Otorhinolaryngology SC Otorhinolaryngology GA 946FE UT WOS:000304336100009 PM 22724280 ER PT J AU Mehta, DD Zeitels, SM Burns, JA Friedman, AD Deliyski, DD Hillman, RE AF Mehta, Daryush D. Zeitels, Steven M. Burns, James A. Friedman, Aaron D. Deliyski, Dimitar D. Hillman, Robert E. TI High-Speed Videoendoscopic Analysis of Relationships Between Cepstral-Based Acoustic Measures and Voice Production Mechanisms in Patients Undergoing Phonomicrosurgery SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE acoustics; cepstrum; high-speed videoendoscopy; laryngology; phonosurgery ID PHONOSURGICAL TREATMENT; PEAK PROMINENCE; DYSPHONIA; SIGNALS AB Objectives: There is increased interest in using cepstral-based acoustic measures for objective clinical voice assessment because of their apparent advantages over more time-honored methods, but there is a paucity of information about how these newer measures relate to underlying phonatory mechanisms. Methods: We investigated the relationships between the acoustic cepstral peak magnitude (CPM) and high-speed videoendoscopy (HSV)-based measures of vocal fold phonatory function in 20 subjects who underwent phonomicrosurgery for vocal fold lesions. Acoustic and imaging data were acquired during sustained vowel phonation before and after surgery. Results: The changes in the measures between presurgical and postsurgical assessments showed that the CPM correlated significantly with an HSV-based measure combining fundamental frequency deviation and average speed quotient (r = 0.70; p < 0.001) in a multiple linear regression, and that the variation in the CPM could also be attributed to trading relationships between the HSV-based measures of vibratory phase asymmetry and glottal closure. Conclusions: These initial results demonstrate that the clinical utility of cepstral-based measures can be enhanced by a better understanding of how these acoustic measures relate to underlying phonatory mechanisms. The CPM seems to integrate information about aperiodicity in vocal fold vibration, the relative speed of glottal closure, and estimates of glottal noise generation. C1 [Mehta, Daryush D.; Zeitels, Steven M.; Burns, James A.; Friedman, Aaron D.; Hillman, Robert E.] Massachusetts Gen Hosp, Ctr Laryngeal Surg & Voice Rehabil, Boston, MA 02114 USA. [Zeitels, Steven M.; Burns, James A.; Friedman, Aaron D.; Hillman, Robert E.] Harvard Univ, Sch Med, Dept Surg, Boston, MA 02115 USA. [Deliyski, Dimitar D.] Cincinnati Childrens Hosp Med Ctr, Commun Sci Res Ctr, Cincinnati, OH USA. [Deliyski, Dimitar D.] Univ Cincinnati, Dept Otolaryngol Head & Neck Surg, Cincinnati, OH USA. RP Hillman, RE (reprint author), Massachusetts Gen Hosp, Ctr Laryngeal Surg & Voice Rehabil, 1 Bowdoin Sq,11th Floor, Boston, MA 02114 USA. FU Eugene B. Casey Foundation; Institute of Laryngology and Voice Restoration; NIH [R01 DC007640] FX From the Center for Laryngeal Surgery and Voice Rehabilitation, Massachusetts General Hospital (Mehta, Zeitels, Burns, Friedman, Hillman), and the Department of Surgery, Harvard Medical School (Zeitels, Burns, Friedman, Hillman), Boston, Massachusetts, and the Communication Sciences Research Center, Cincinnati Children's Hospital Medical Center (Deliyski), and the Department of Otolaryngology-Head and Neck Surgery, University of Cincinnati (Deliyski), Cincinnati, Ohio. This work was supported in part by the Eugene B. Casey Foundation, the Institute of Laryngology and Voice Restoration, and NIH grant R01 DC007640. Its contents are solely the responsibility of the authors and do not necessarily represent the official views of the NIH. CR Awan SN, 2010, CLIN LINGUIST PHONET, V24, P742, DOI 10.3109/02699206.2010.492446 Boersma P., 2009, PRAAT DOING PHONETIC Dejonckere PH, 1996, ORL J OTO-RHINO-LARY, V58, P326 DEJONCKERE PH, 1994, CLIN LINGUIST PHONET, V8, P161, DOI 10.3109/02699209408985304 DEKROM G, 1993, J SPEECH HEAR RES, V36, P254 Deliyski DD, 2008, FOLIA PHONIATR LOGO, V60, P33, DOI 10.1159/000111802 Heman-Ackah YD, 2003, ANN OTO RHINOL LARYN, V112, P324 Heman-Ackah YD, 2002, J VOICE, V16, P20, DOI 10.1016/S0892-1997(02)00067-X Hillenbrand J, 1996, J SPEECH HEAR RES, V39, P311 HOLMBERG EB, 1995, J SPEECH HEAR RES, V38, P1212 Maryn Y, 2010, J VOICE, V24, P540, DOI 10.1016/j.jvoice.2008.12.014 Mehta DD, 2010, ANN OTO RHINOL LARYN, V119, P1 Mehta DD, 2011, J SPEECH LANG HEAR R, V54, P47, DOI 10.1044/1092-4388(2010/10-0026) Mehta DD, 2008, CURR OPIN OTOLARYNGO, V16, P211, DOI 10.1097/MOO.0b013e3282fe96ce Murphy PJ, 2006, J ACOUST SOC AM, V120, P2896, DOI 10.1121/1.2355483 WOO P, 1994, J VOICE, V8, P186, DOI 10.1016/S0892-1997(05)80311-X Zeitels SM, 2002, ANN OTO RHINOL LARYN, V111, P21 Zeitels SM, 2008, ANN OTOL RHINOL S199, V117, P1 ZEITELS SM, 1991, OTOLARYNG HEAD NECK, V105, P478 NR 19 TC 6 Z9 6 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD MAY PY 2012 VL 121 IS 5 BP 341 EP 347 PG 7 WC Otorhinolaryngology SC Otorhinolaryngology GA 946FE UT WOS:000304336100010 PM 22724281 ER PT J AU Kim, JK Lee, JH Lee, SH Hong, SC Cho, JH AF Kim, Jin Kook Lee, Ji Hye Lee, Seung-Hoon Hong, Seok-Chan Cho, Jae Hoon TI Effects of Sleep-Disordered Breathing on Physical Traits, School Performance, and Behavior of Korean Elementary School Students in the Upper Grade Levels SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE behavioral disturbance; child; Korea; school performance; sleep-disordered breathing ID COGNITIVE DYSFUNCTION; ACADEMIC-PERFORMANCE; INTERMITTENT HYPOXIA; APNEA SYNDROME; AGED CHILDREN; PREVALENCE; COMMUNITY; SYMPTOMS; RISK AB Objectives: We investigated the physical traits, school performance, and behavior of Korean children with sleep-disordered breathing (SDB). Methods: We recruited 679 students from an elementary school in Seoul, Korea. We used a survey to collect information on the absence or presence of SDB at both the child's preschool age and his or her current age and on the degree of behavioral disturbance. Physical traits and examination scores were also analyzed. We divided the children into 4 groups: non-SDB group, past SDB group, recent SDB group, and continuous SDB group. Comparisons between these four groups were conducted. Results: Sixty-one students were excluded because of incomplete information. The current body mass index was significantly higher in the past (19.7 +/- 3.6), recent (21.2 +/- 3.6), and continuous SDB groups (20.7 +/- 3.9) than in the non-SDB group (18.8 +/- 3.2), but only for male students (p < 0.001). The examination scores were not different among the four groups, but the behavioral disturbance scores were much higher in the past, recent, and continuous SDB groups than in the non-SDB group for both genders. Conclusions: Among these Korean elementary school students in the upper grade levels, the presence of current or past SDB appeared to influence the current body mass index in boys and the presence of behavioral disturbances in both genders. However, SDB was not associated with school performance. C1 [Kim, Jin Kook; Hong, Seok-Chan; Cho, Jae Hoon] Konkuk Univ, Dept Otorhinolaryngol Head & Neck Surg, Coll Med, Seoul 143729, South Korea. [Lee, Ji Hye] Seoul Natl Univ, Dept Social Studies Educ, Grad Sch, Seoul, South Korea. [Lee, Seung-Hoon] Korea Univ, Coll Med, Dept Otorhinolaryngol Head & Neck Surg, Seoul 136705, South Korea. RP Cho, JH (reprint author), Konkuk Univ, Dept Otorhinolaryngol Head & Neck Surg, Coll Med, 4-12 Hwayang Dong, Seoul 143729, South Korea. FU Ministry of Health and Welfare, Republic of Korea [A100884] FX From the Department of Otorhinolaryngology Head and Neck Surgery, College of Medicine, Konkuk University (Kim, Hong, Cho), the Department of Social Studies Education, Graduate School, Seoul National University (J.H. Lee), and the Department of Otorhinolaryngology Head and Neck Surgery, College of Medicine, Korea University (S.-H. Lee), Seoul, Korea. Jin Kook Kim and Ji Hye Lee contributed equally to this work. This work was supported by a grant of the Korea Health Technology R&D Project, Ministry of Health and Welfare, Republic of Korea (A100884). CR Archbold Kristen Hedger, 2004, Biol Res Nurs, V5, P168, DOI 10.1177/1099800403260261 Arman AR, 2005, CHILD CARE HLTH DEV, V31, P707, DOI 10.1111/j.1365-2214.2005.00561.x Bixler EO, 2009, SLEEP, V32, P731 Carvalho LBC, 2005, J CHILD NEUROL, V20, P400 Castronovo V, 2003, J PEDIATR-US, V142, P377, DOI 10.1067/mpd.2003.118 Chervin RD, 2000, SLEEP MED, V1, P21, DOI 10.1016/S1389-9457(99)00009-X Chervin RD, 2003, SLEEP MED, V4, P21, DOI 10.1016/S1389-9457(02)00243-5 Choi JH, 2010, ANN OTO RHINOL LARYN, V119, P656 Gottlieb DJ, 2004, J PEDIATR-US, V145, P458, DOI 10.1016/j.jpeds.2004.05.039 Gozal D, 2008, SLEEP MED, V9, P254, DOI 10.1016/j.sleep.2007.04.013 Gozal D, 1998, PEDIATRICS, V102, P616, DOI 10.1542/peds.102.3.616 Gozal D, 2007, AM J RESP CRIT CARE, V176, P188, DOI 10.1164/rccm.200610-1519OC Karpinski AC, 2008, SLEEP MED, V9, P418, DOI 10.1016/j.sleep.2007.06.004 Kim JK, 2011, ANN OTO RHINOL LARYN, V120, P268 Mitchell Ron B, 2008, Mo Med, V105, P267 Mitchell RB, 2006, LARYNGOSCOPE, V116, P956, DOI 10.1097/01.MLG.0000216413.22408.FD Owens JA, 2009, PEDIATR PULM, V44, P417, DOI 10.1002/ppul.20981 Pang KP, 2004, J LARYNGOL OTOL, V118, P275 Perez-Chada D, 2007, SLEEP, V30, P1698 Row BW, 2003, AM J RESP CRIT CARE, V167, P1548, DOI 10.1164/rccm.200209-1050OC Sahin U, 2009, MED PRIN PRACT, V18, P458, DOI 10.1159/000235895 Schechter MS, 2002, PEDIATRICS, V109, DOI 10.1542/peds.109.4.e69 Spicuzza L, 2009, SLEEP MED REV, V13, P111, DOI 10.1016/j.smrv.2008.07.001 Tauman R, 2006, PAEDIATR RESPIR REV, V7, P247, DOI 10.1016/j.prrv.2006.08.003 Urschitz MS, 2003, AM J RESP CRIT CARE, V168, P464, DOI 10.1164/rccm.200212-1397OC NR 25 TC 2 Z9 2 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD MAY PY 2012 VL 121 IS 5 BP 348 EP 354 PG 7 WC Otorhinolaryngology SC Otorhinolaryngology GA 946FE UT WOS:000304336100011 PM 22724282 ER PT J AU Fukushima, K Kasai, N Omori, K Sugaya, A Fujiyoshi, A Taguchi, T Konishi, T Sugishita, S Takei, W Fujino, H Ojima, T Nishizaki, K AF Fukushima, Kunihiro Kasai, Norio Omori, Kana Sugaya, Akiko Fujiyoshi, Akie Taguchi, Tomoko Konishi, Takayuki Sugishita, Syuuhei Takei, Wataru Fujino, Hiroshi Ojima, Toshiyuki Nishizaki, Kazunori TI Assessment Package for Language Development in Japanese Hearing-Impaired Children (ALADJIN) as a Test Battery for the Development of Practical Communication SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE communication; hearing impairment; language development; syntax; vocabulary ID COCHLEAR IMPLANTS; VERBAL FLUENCY; DEAF-CHILDREN; VOCABULARY; OUTCOMES AB Objectives: The measurement of language development in hearing-impaired children is an important step in assessing the appropriateness of an intervention. We proposed a set of language tests (the Assessment Package for Language Development in Japanese Hearing-Tmpaired Children [ALADJIN]) to evaluate the development of practical communication skills. This package consisted of communication skills (TQAID), comprehensive (PVT-R and SCTAW) and productive vocabulary (WFT), comprehensive and productive syntax (STA), and the STRAW. Methods: A total of 638 children with greater than 70-dB hearing impairment were subjected to this set of language tests. Additional tests, including the PARS, the RCPM, and parental questionnaires, were administered to assess the backgrounds of the children. Results: A trimodal distribution was observed among hearing-impaired children by the histogram-based analysis of each test. Conclusions: The ALADJIN is a useful Japanese-language evaluation kit for hearing-impaired children. C1 [Fukushima, Kunihiro] Okayama Univ, Postgrad Sch Med Dent & Pharmaceut Sci, Dept Otolaryngol Head & Neck Surg, Kita Ku, Okayama 7008558, Japan. [Fujiyoshi, Akie; Taguchi, Tomoko; Konishi, Takayuki] Okayama Univ Hosp, Gen Rehabil Ctr, Okayama, Japan. [Fujino, Hiroshi] Tokyo Gakugei Univ, Dept Comprehens Educ Sci, Tokyo, Japan. [Kasai, Norio; Omori, Kana] Assoc Tech Aids, Tokyo, Japan. [Sugishita, Syuuhei] Takasago Municipal Hosp, Dept Rehabil, Takasago, Hyogo, Japan. [Takei, Wataru] Kanazawa Univ, Fac Educ, Kanazawa, Ishikawa, Japan. [Ojima, Toshiyuki] Hamamatsu Univ Sch Med, Dept Community Hlth & Prevent Med, Hamamatsu, Shizuoka 4313192, Japan. RP Fukushima, K (reprint author), Okayama Univ, Postgrad Sch Med Dent & Pharmaceut Sci, Dept Otolaryngol Head & Neck Surg, Kita Ku, 2-5-1 Shikata Cho, Okayama 7008558, Japan. FU Ministry of Health, Labor, and Welfare of Japan FX From the Department of Otolaryngology-Head and Neck Surgery, Okayama University Postgraduate School of Medicine, Dentistry, and Pharmaceutical Science (Fukushima, Kasai, Omori, Sugaya, Fujiyoshi, Taguchi, Nishizaki), and the General Rehabilitation Center, Okayama University Hospital (Fujiyoshi, Taguchi, Konishi), Okayama; the Association for Technical Aids (Kasai, Omori) and the Department of Comprehensive Educational Science, Tokyo Gakugei University (Fujino), Tokyo; the Department of Rehabilitation, Takasago Municipal Hospital, Takasago (Sugishita); the Faculty of Education, Kanazawa University, Kanazawa (Takei); and the Department of Community Health and Preventive Medicine, Hamamatsu University School of Medicine, Hamamatsu (Ojima); Japan. This work was a part of the Research on Sensory and Communicative Disorders project, which is supported by a grant from the Ministry of Health, Labor, and Welfare of Japan. CR Anderson Ilona, 2008, Cochlear Implants Int, V9, P119, DOI 10.1002/cii.361 [Anonymous], 2004, HEAR ASS HEAR IMP CH, P3 [Anonymous], 2005, JPN J LOGOP PHONIATR, V46, P185 Apuzzo Mah-Rya L., 1995, Seminars in Hearing, V16, P124, DOI 10.1055/s-0028-1083710 Arffa S, 2007, ARCH CLIN NEUROPSYCH, V22, P969, DOI 10.1016/j.acn.2007.08.001 Fagan MK, 2007, J DEAF STUD DEAF EDU, V12, P461, DOI 10.1093/deafed/enm023 GEERS A, 1994, VOLTA REV, V96, P131 GILBERTSON M, 1995, J SPEECH HEAR RES, V38, P630 Haruhara N, 2002, STANDARDIZED COMPREH Hawker K, 2008, EAR HEARING, V29, P467, DOI 10.1097/AUD.0b013e318167b857 Hogan A, 1997, DISABIL REHABIL, V19, P235 Koren R, 2005, ARCH CLIN NEUROPSYCH, V20, P1087, DOI 10.1016/j.acn.2005.06.012 Kunisue K, 2007, INT J PEDIATR OTORHI, V71, P1671, DOI 10.1016/j.ijport.2007.06.015 Lin FR, 2007, EAR HEARING, V28, P703, DOI 10.1097/AUD.0b013e31812f71f4 Nakajima R, 1997, JPN J LOGOP PHONIATR, V38, P161 Nikolopoulos TP, 2005, INT J PEDIATR OTORHI, V69, P175, DOI 10.1016/j.ijporl.2004.08.016 Riva D, 2000, BRAIN LANG, V71, P267, DOI 10.1006/brln.1999.2166 Satake T, 1996, MANUAL TEST QUERY AN Toyama H, 1994, JPN J LOGOPED PHONIA, V35, P338 Ueno K., 2008, PICTURE VOCABULARY T Uno A, 2006, READING WRITING SCRE Uno A, 2009, READ WRIT, V22, P755, DOI 10.1007/s11145-008-9128-8 Wake M, 2004, EAR HEARING, V25, P1, DOI 10.1097/01.AUD.0000111262.12219.2F Watkin PM, 2011, ARCH DIS CHILD, V96, P62, DOI 10.1136/adc.2010.185819 Yamada A, 2007, PSYCHIAT CLIN NEUROS, V61, P651, DOI 10.1111/j.1440-1819.2007.01736.x NR 25 TC 0 Z9 0 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD APR PY 2012 VL 121 IS 4 SU 202 BP 3 EP 15 PN 2 PG 13 WC Otorhinolaryngology SC Otorhinolaryngology GA 927CE UT WOS:000302883800001 ER PT J AU Kasai, N Fukushima, K Omori, K Sugaya, A Ojima, T AF Kasai, Norio Fukushima, Kunihiro Omori, Kana Sugaya, Akiko Ojima, Toshiyuki TI Effects of Early Identification and Intervention on Language Development in Japanese Children With Prelingual Severe to Profound Hearing Impairment SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE early identification; early intervention; hearing loss; language development; newborn hearing screening ID COCHLEAR IMPLANT; DEAFNESS AB Objectives: Early identification and intervention for prelingual bilateral severe to profound hearing loss is supposed to reduce the delay in language development. Many countries have implemented early detection and hearing intervention and conducted regional universal newborn hearing screening (UNHS). However, the benefits of UNHS in later childhood have not yet been confirmed, although language development at school age has a lifelong impact on children's future. Our Research on Sensory and Communicative Disorders project attempted to reveal the effects of UNHS and those of early intervention on the development of verbal communication in Japanese children. Methods: In this study, 319 children with prelingual bilateral severe to profound hearing loss, 4 to 10 years of age, were evaluated with the Test of Question-Answer Interaction Development used as an objective variable. Participation in UNHS and early intervention were used as explanatory variables. The adjusted odds ratio (AOR) was calculated after adjusting several confounding factors with use of logistic regression analysis. In addition, caregivers' answers were obtained by a questionnaire, and the process of diagnosis with and without UNHS was analyzed retrospectively. Results: Early intervention was significantly associated with better language development (AOR, 3.23; p < 0.01). Participation in UN HS may contribute to better language development to some extent (AOR, 1.32), but not one that was statistically significant (p = 0.37). However, UNHS was significantly associated with early intervention (AOR, 20.21; p < 0.001). The questionnaire results indicated a lag in treatment after UNHS in more than 40% of screened cases. Conclusions: Early intervention strongly influenced language development. It is necessary to ensure that early identification leads directly to early intervention. C1 [Fukushima, Kunihiro] Okayama Univ, Postgrad Sch Med Dent & Pharmaceut Sci, Dept Otolaryngol Head & Neck Surg, Kita Ku, Okayama 7008558, Japan. [Kasai, Norio; Omori, Kana] Assoc Tech Aids, Tokyo, Japan. [Ojima, Toshiyuki] Hamamatsu Univ Sch Med, Dept Community Hlth & Prevent Med, Hamamatsu, Shizuoka 4313192, Japan. RP Fukushima, K (reprint author), Okayama Univ, Postgrad Sch Med Dent & Pharmaceut Sci, Dept Otolaryngol Head & Neck Surg, Kita Ku, 2-5-1 Shikata Cho, Okayama 7008558, Japan. RI ibrahim, raquib/F-5078-2012 FU Ministry of Health, Labor, and Welfare of Japan FX From the Department of Otolaryngology-Head and Neck Surgery, Okayama University Postgraduate School of Medicine, Dentistry, and Pharmaceutical Science, Okayama (Kasai, Fukushima, Omori, Sugaya); the Association for Technical Aids, Tokyo (Kasai, Omori); and the Department of Community Health and Preventive Medicine, Hamamatsu University School of Medicine, Hamamatsu (Ojima); Japan. This work was a part of the Research on Sensory and Communicative Disorders project, which is supported by a grant from the Ministry of Health, Labor, and Welfare of Japan. CR Busa J, 2007, PEDIATRICS, V120, P898, DOI 10.1542/peds.2007-2333 Benesse Educational Research and Development Center, 2008, 3 SURV CHILD CAR, P34 Fitzpatrick E, 2007, J MED SCREEN, V14, P123, DOI 10.1258/096914107782066248 Fukuda S, 2003, INT J PEDIATR OTORHI, V67, P1061, DOI 10.1016/S0165-5876(03)00187-3 Fukuda S, 2003, INT J PEDIATR OTORHI, V67, P627, DOI 10.1016/S0165-5876(03)00016-8 Fukushima K, 2008, ANN OTO RHINOL LARYN, V117, P166 Fukushima K, 2002, INT J PEDIATR OTORHI, V62, P151, DOI 10.1016/S0165-5876(01)00619-X Kamio Y., 2006, CLIN PSYCHIATR, V48, P495 Moeller MP, 2000, PEDIATRICS, V106, DOI 10.1542/peds.106.3.e43 PRESSMAN LJ, 1999, J DEAF STUDIES DEAF, V0004 Raven J. C., 1965, GUIDE USING COLOURED Satake T, 1996, MANUAL TEST QUERY AN Toyama H, 1994, JPN J LOGOPED PHONIA, V35, P338 Uno A, 2006, READING WRITING SCRE Uno A, 2009, READ WRIT, V22, P755, DOI 10.1007/s11145-008-9128-8 Watkin PM, 2011, ARCH DIS CHILD, V96, P62, DOI 10.1136/adc.2010.185819 Wolff R, 2010, ARCH DIS CHILD, V95, P130, DOI 10.1136/adc.2008.151092 Yoshinaga-Itano C, 2001, Semin Neonatol, V6, P521, DOI 10.1053/siny.2001.0075 Yoshinaga-Itano C, 1999, OTOLARYNG CLIN N AM, V32, P1089, DOI 10.1016/S0030-6665(05)70196-1 Yoshinaga-Itano C, 2010, OTOL NEUROTOL, V31, P1268, DOI 10.1097/MAO.0b013e3181f1ce07 Yoshinaga-Itano C, 2000, J Perinatol, V20, pS132 Yoshinaga-Itano C, 1998, PEDIATRICS, V102, P1161, DOI 10.1542/peds.102.5.1161 NR 22 TC 1 Z9 1 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD APR PY 2012 VL 121 IS 4 SU 202 BP 16 EP 20 PN 2 PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA 927CE UT WOS:000302883800002 ER PT J AU Sugaya, A Fukushima, K Kasai, N Fujiyoshi, A Taguchi, T Omori, K Ojima, T Nishizaki, K AF Sugaya, Akiko Fukushima, Kunihiro Kasai, Norio Fujiyoshi, Akie Taguchi, Tomoko Omori, Kana Ojima, Toshiyuki Nishizaki, Kazunori TI Language Ability in the Intermediate-Scoring Group of Hearing-Impaired Children SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE academic achievement; hearing impairment; interpersonal communication; language development ID COCHLEAR IMPLANT; VERBAL FLUENCY; SKILLS AB Objectives: Language development is a key issue in hearing-impaired children. However, interpersonal differences complicate our understanding of the situation. The bimodal or trimodal distribution of language scores in our other reports in this publication imply the presence of fundamental differences among these groups. The characteristic aspects of each group were profiled according to language data. Methods: We divided 268 children with prelingual severe to profound hearing impairment into 3 groups according to their trimodal distribution observed on histogram-based analysis of their responses to the Test of Question-Answer Interaction Development. Test results in several language domains, including productive and comprehensive vocabulary, productive and comprehensive syntax, and academic achievement, were profiled and compared among these 3 groups. Results: Significant differences were observed in the results of the Word Fluency Test, the Picture Vocabulary Test Revised, and the Syntax Test of Aphasia among the 3 groups. No significant difference was observed between groups who were lower-scoring and intermediate-scoring on the academic achievement tests referred to as Criterion Referenced Test II and the Standardized Comprehension Test for Abstract Words. Only the higher-scoring group showed excellent results. The demographic factors were not significantly different among the 3 groups. Conclusions: Relatively poor academic achievement despite fair language production was the dominant feature of the intermediate-scoring group. This profile might correlate with academic failure in school. C1 [Fukushima, Kunihiro] Okayama Univ, Postgrad Sch Med Dent & Pharmaceut Sci, Dept Otolaryngol Head & Neck Surg, Kita Ku, Okayama 7008558, Japan. [Fujiyoshi, Akie; Taguchi, Tomoko] Okayama Univ Hosp, Gen Rehabil Ctr, Okayama, Japan. [Kasai, Norio; Omori, Kana] Assoc Tech Aids, Tokyo, Japan. [Ojima, Toshiyuki] Hamamatsu Univ Sch Med, Dept Community Hlth & Prevent Med, Hamamatsu, Shizuoka 4313192, Japan. RP Fukushima, K (reprint author), Okayama Univ, Postgrad Sch Med Dent & Pharmaceut Sci, Dept Otolaryngol Head & Neck Surg, Kita Ku, 2-5-1 Shikata Cho, Okayama 7008558, Japan. FU Ministry of Health, Labor, and Welfare of Japan FX From the Department of Otolaryngology-Head and Neck Surgery, Okayama University Postgraduate School of Medicine, Dentistry, and Pharmaceutical Science (Sugaya, Fukushima, Kasai, Fujiyoshi, Taguchi, Omori, Nishizaki), and the General Rehabilitation Center, Okayama University Hospital (Fujiyoshi, Taguchi), Okayama; the Association for Technical Aids, Tokyo (Kasai, Omori), and the Department of Community Health and Preventive Medicine, Hamamatsu University School of Medicine, Hamamatsu (Ojima), Japan. This work was a part of the Research on Sensory and Communicative Disorders project, which is supported by a grant from the Ministry of Health, Labor, and Welfare of Japan. CR Busa J, 2007, PEDIATRICS, V120, P898, DOI 10.1542/peds.2007-2333 [Anonymous], 2005, JPN J LOGOP PHONIATR, V46, P185 Arffa S, 2007, ARCH CLIN NEUROPSYCH, V22, P969, DOI 10.1016/j.acn.2007.08.001 atsuno C, 2007, MANUAL CRITERION REF Beitchman JH, 2008, J CHILD PSYCHOL PSYC, V49, P626, DOI 10.1111/j.1469-7610.2008.01878.x Fitzpatrick EM, 2011, EAR HEARING, V32, P605, DOI 10.1097/AUD.0b013e31821348ae Fukuda S, 2003, INT J PEDIATR OTORHI, V67, P1061, DOI 10.1016/S0165-5876(03)00187-3 Fukuda S, 2003, INT J PEDIATR OTORHI, V67, P627, DOI 10.1016/S0165-5876(03)00016-8 Fukushima K, 2002, INT J PEDIATR OTORHI, V62, P151, DOI 10.1016/S0165-5876(01)00619-X Haruhara N, 2002, STANDARDIZED COMPREH Koren R, 2005, ARCH CLIN NEUROPSYCH, V20, P1087, DOI 10.1016/j.acn.2005.06.012 McPhillips HA, 2010, J PEDIATR-US, V157, P170, DOI 10.1016/j.jpeds.2010.05.008 Nakajima R, 1997, JPN J LOGOP PHONIATR, V38, P161 Riva D, 2000, BRAIN LANG, V71, P267, DOI 10.1006/brln.1999.2166 Satake T, 1996, MANUAL TEST QUERY AN Schjolberg S, 2011, J DEV BEHAV PEDIATR, V32, P375, DOI 10.1097/DBP.0b013e31821bd1dd Ueno K., 2008, PICTURE VOCABULARY T Uno A, 2006, READING WRITING SCRE Uno A, 2009, READ WRIT, V22, P755, DOI 10.1007/s11145-008-9128-8 Watkin P. M., 2007, PEDIATRICS, V120, P694 Yamada A, 2007, PSYCHIAT CLIN NEUROS, V61, P651, DOI 10.1111/j.1440-1819.2007.01736.x Yoshinaga-Itano C, 2010, OTOL NEUROTOL, V31, P1268, DOI 10.1097/MAO.0b013e3181f1ce07 NR 22 TC 0 Z9 0 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD APR PY 2012 VL 121 IS 4 SU 202 BP 21 EP 27 PN 2 PG 7 WC Otorhinolaryngology SC Otorhinolaryngology GA 927CE UT WOS:000302883800003 ER PT J AU Fujiyoshi, A Fukushima, K Taguchi, T Omori, K Kasai, N Nishio, S Sugaya, A Nagayasu, R Konishi, T Sugishita, S Fujita, J Nishizaki, K Shiroma, M AF Fujiyoshi, Akie Fukushima, Kunihiro Taguchi, Tomoko Omori, Kana Kasai, Norio Nishio, Shinya Sugaya, Akiko Nagayasu, Rie Konishi, Takayuki Sugishita, Syuuhei Fujita, Jyunpei Nishizaki, Kazunori Shiroma, Masae TI Syntactic Development in Japanese Hearing-Impaired Children SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE cochlear implant; hearing impairment; language development; syntactic development ID LANGUAGE AB Objectives: This study examined syntactic development of auditory comprehension of sentences in Japanese-speaking school-age children with and without hearing impairment. Methods: In total, 592 preschool and school-age children (421 normal-hearing and 171 hearing-impaired) were included in this cross-sectional observation study conducted using the Syntactic Processing Test for Aphasia for Japanese language users. Linear regression analysis was used to determine the estimated age at which each syntactic structure was acquired. Results: Acquisition of syntactic structures was observed in hearing-impaired and normal-hearing children. Basic word order sentences of agent-object-verb and the goal benefactive construction were acquired at preschool age (earlier group), whereas reverse word order sentences of object-agent-verb, source benefactive construction, passive voice, and relative clauses were acquired at school age (later group). The results showed that many hearing-impaired children may not acquire Japanese grammatical structures until the age of 12 years. Conclusions: Adequate screening for language development for school-age hearing-impaired children is required for an effective intervention. C1 [Fukushima, Kunihiro] Okayama Univ, Postgrad Sch Med Dent & Pharmaceut Sci, Dept Otolaryngol Head & Neck Surg, Kita Ku, Okayama 7008558, Japan. [Fujiyoshi, Akie; Taguchi, Tomoko; Konishi, Takayuki; Fujita, Jyunpei] Okayama Univ Hosp, Gen Rehabil Ctr, Okayama, Japan. [Omori, Kana; Kasai, Norio] Assoc Tech Aids, Tokyo, Japan. [Nishio, Shinya] Shinshu Univ, Dept Otolaryngol, Matsumoto, Nagano 390, Japan. [Sugishita, Syuuhei] Takasago Municipal Hosp, Dept Rehabil, Takasago, Hyogo, Japan. [Shiroma, Masae] Int Univ Hlth & Welf, Sch Hlth Sci, Dept Speech & Hearing Sci, Ohtawara, Japan. RP Fukushima, K (reprint author), Okayama Univ, Postgrad Sch Med Dent & Pharmaceut Sci, Dept Otolaryngol Head & Neck Surg, Kita Ku, 2-5-1 Shikata Cho, Okayama 7008558, Japan. FU Ministry of Health, Labor, and Welfare of Japan FX From the Department of Otolaryngology-Head and Neck Surgery, Okayama University Postgraduate School of Medicine, Dentistry, and Pharmaceutical Science (Fujiyoshi, Fukushima, Taguchi, Omori, Kasai, Sugaya, Nagayasu, Nishizaki), and the General Rehabilitation Center, Okayama University Hospital (Fujiyoshi, Taguchi, Konishi, Fujita), Okayama; the Association for Technical Aids, Tokyo (Omori, Kasai); the Department of Otolaryngology, Shinshu University, Matsumoto (Nishio); the Department of Rehabilitation, Takasago Municipal Hospital, Takasago (Sugishita); and the Department of Speech and Hearing Science, School of Health Science, International University of Health and Welfare, Ohtawara (Shiroma); Japan. This work was a part of the Research on Sensory and Communicative Disorders project, which is supported by a grant from the Ministry of Health, Labor, and Welfare of Japan. CR Bishop D. V. M., 2003, TEST RECEPTION GRAMM Carrow-Woolfolk E., 1999, TEST AUDITORY COMPRE Daneman M., 1995, VOLTA REV, V97, P225 DAVIS J, 1975, J SPEECH HEAR RES, V18, P281 Friedmann N, 2006, J DEAF STUD DEAF EDU, V11, P56, DOI 10.1093/deafed/enj002 Fujita I, 2009, SYNTACTIC PROCESSING Garrison W, 1997, J DEAF STUD DEAF EDU, V2, P78 Haruhara N, 2002, STANDARDIZED COMPREH Hawker K, 2008, EAR HEARING, V29, P467, DOI 10.1097/AUD.0b013e318167b857 Matsuyama N, 2006, B TOKYO GAKUGEI U, P161 Moeller MP, 2007, EAR HEARING, V28, P740 Nakamura M, 2000, TOKYO SEITOKU U B, V7, P91 Raven JC, 1995, RAVENS COLOURED PROG Sawa T., 2011, JAPANESE ASS SPECIAL, V48, P605 NR 14 TC 0 Z9 0 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD APR PY 2012 VL 121 IS 4 SU 202 BP 28 EP 34 PN 2 PG 7 WC Otorhinolaryngology SC Otorhinolaryngology GA 927CE UT WOS:000302883800004 ER PT J AU Sugishita, S Fukushima, K Kasai, N Konishi, T Omori, K Taguchi, T Fujiyoshi, A Ojima, T AF Sugishita, Syuuhei Fukushima, Kunihiro Kasai, Norio Konishi, Takayuki Omori, Kana Taguchi, Tomoko Fujiyoshi, Akie Ojima, Toshiyuki TI Language Development, Interpersonal Communication, and Academic Achievement Among Japanese Children as Assessed by the ALADJIN SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE academic achievement; interpersonal communication skills; language development AB Objectives: Japanese-speaking children in a standard sample were subjected to a test battery (ALADJIN: Assessment Package for Language Development in Japanese Hearing-Impaired Children) to evaluate the effect of language development on both interpersonal communication skills and academic achievement. Methods: A total of 414 preschool and school-age children without hearing impairment were included in this study. The following tests make up the ALADJIN: the Test of Question-Answer Interaction Development (TQAID), the Japanese Language by Criterion Referenced Test-II (CRT-II) for measuring academic achievement, the Picture Vocabulary Test Revised (PVT-R), the Standardized Comprehension Test of Abstract Words (SCTAW), both parts of the Syntactic Processing Test for Aphasia (STA), and the Word Fluency Test (WFT). Means and standard deviations at each academic grade level were calculated, and a multiple regression analysis was performed. Results: A ceiling effect was observed for the TQAID and the STA in children in grade 3 of elementary school, and the scores for the PVT-R, SCTAW, and WFT increased incrementally according to grade level. Multiple regression analysis revealed that the PVT-R, WFT, and STA (production) have predictive power for the results of the TQAID (R = 0.59; R-2 = 0.58; p < 0.0001), whereas the SCTAW and STA (comprehension) have predictive power for the results of the CRT-II. Conclusions: Both vocabulary and syntax are important in communication development among children. The results of our multiple regression analysis suggest that different language domains may play different roles in the development of interpersonal communication skills and in academic achievement. The development of interpersonal communication skills is largely based on productive vocabulary and syntax abilities, whereas academic achievement is largely based on comprehensive vocabulary and syntax abilities. Children who have difficulties in either area should be evaluated with detailed language assessment tools such as the ALADJIN in an effort to aid in the selection of appropriate intervention. C1 [Fukushima, Kunihiro] Okayama Univ, Postgrad Sch Med Dent & Pharmaceut Sci, Dept Otolaryngol Head & Neck Surg, Kita Ku, Okayama 7008558, Japan. [Sugishita, Syuuhei] Takasago Municipal Hosp, Dept Rehabil, Takasago, Hyogo, Japan. [Konishi, Takayuki; Taguchi, Tomoko; Fujiyoshi, Akie] Okayama Univ Hosp, Gen Rehabil Ctr, Okayama, Japan. [Kasai, Norio; Omori, Kana] Assoc Tech Aids, Tokyo, Japan. [Ojima, Toshiyuki] Hamamatsu Univ Sch Med, Dept Community Hlth & Prevent Med, Hamamatsu, Shizuoka 4313192, Japan. RP Fukushima, K (reprint author), Okayama Univ, Postgrad Sch Med Dent & Pharmaceut Sci, Dept Otolaryngol Head & Neck Surg, Kita Ku, 2-5-1 Shikata Cho, Okayama 7008558, Japan. FU Ministry of Health, Labor, and Welfare of Japan FX From the Department of Rehabilitation, Takasago Municipal Hospital, Takasago (Sugishita); the Department of Otolaryngology-Head and Neck Surgery, Okayama University Postgraduate School of Medicine, Dentistry, and Pharmaceutical Science (Fukushima, Kasai, Omori, Taguchi, Fujiyoshi), and the General Rehabilitation Center, Okayama University Hospital (Konishi, Taguchi, Fujiyoshi), Okayama; the Association for Technical Aids, Tokyo (Kasai, Omori); and the Department of Community Health and Preventive Medicine, Hamamatsu University School of Medicine, Hamamatsu (Ojima); Japan. This work was a part of the Research on Sensory and Communicative Disorders project, which is supported by a grant from the Ministry of Health, Labor, and Welfare of Japan. CR [Anonymous], 2005, JPN J LOGOP PHONIATR, V46, P185 atsuno C, 2007, MANUAL CRITERION REF Fujita I, 2009, TOCH JAP JAP WORKSH HARGROVE ML, 1982, EDUCATION, V102, P366 Haruhara N, 2002, STANDARDIZED COMPREH KOEDA T, 1990, No To Hattatsu, V22, P235 Koren R, 2005, ARCH CLIN NEUROPSYCH, V20, P1087, DOI 10.1016/j.acn.2005.06.012 Noboru T., 2006, COMMUNICATION ASS JA, V23, P118 Sasamori H, 2010, NATL I SPECIAL NEEDS, V38, P3 Satake T, 1996, MANUAL TEST QUERY AN Ueno K., 2008, PICTURE VOCABULARY T Uno A, 2006, READING WRITING SCRE NR 12 TC 1 Z9 1 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD APR PY 2012 VL 121 IS 4 SU 202 BP 35 EP 39 PN 2 PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA 927CE UT WOS:000302883800005 ER PT J AU Lindberg, S Lewander, M Svensson, T Siemund, R Svanberg, K Svanberg, S AF Lindberg, Sven Lewander, Marta Svensson, Tomas Siemund, Roger Svanberg, Katarina Svanberg, Sune TI Method for Studying Gas Composition in the Human Mastoid Cavity by Use of Laser Spectroscopy SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE laser spectroscopy; mastoid cavity; oxygen; water vapor ID MIDDLE-EAR PRESSURE; AIR CELL SYSTEM; OTITIS-MEDIA; MASS-SPECTROMETRY; EFFUSION; PNEUMATIZATION; CHILDREN; SIZE AB Objectives: We evaluated a method for gas monitoring in the mastoid cavity using tunable diode laser spectroscopy by comparing it to simultaneously obtained computed tomographic (CT) scans. Methods: The presented optical technique measures free gases, oxygen (O2), and water vapor (H2O) within human tissue by use of low-power diode lasers. Laser light was sent into the tip of the mastoid process, and the emerging light at the level of the antrum was captured with a detector placed on the skin. The absorption of H2O was used to monitor the probed gas volume of the mastoid cavity, and it was compared to the CT scan measured volume. The ratio between O2 absorption and H2O absorption estimated the O2 content in the mastoid cavity and thus the ventilation. The parameters were compared to the grading of mastoid cavities based on the CT scans (n = 31). The reproducibility of the technique was investigated by measuring each mastoid cavity 4 times. Results: Both O2 and H2O were detected with good reproducibility. The H2O absorption and the CT volume correlated (r = 0.69). The average ratio between the normalized O2 absorption and the H2O absorption signals was 0.7, indicating a lower O2 content than in surrounding air (expected ratio, 1.0), which is consistent with previous findings made by invasive techniques. All mastoid cavities with radiologic signs of disease were detected. Conclusions: Laser spectroscopy monitoring appears to be a usable tool for noninvasive investigations of gas composition in the mastoid cavity, providing important clinical information regarding size and ventilation. C1 [Lindberg, Sven] Univ Lund Hosp, Dept Otorhinolaryngol, SE-22185 Lund, Sweden. [Siemund, Roger] Univ Lund Hosp, Dept Diagnost Radiol, SE-22185 Lund, Sweden. [Svanberg, Katarina] Univ Lund Hosp, Dept Oncol, SE-22185 Lund, Sweden. [Lewander, Marta; Svensson, Tomas; Svanberg, Sune] Lund Univ, Div Atom Phys, Lund, Sweden. RP Lindberg, S (reprint author), Univ Lund Hosp, Dept Otorhinolaryngol, SE-22185 Lund, Sweden. RI Lewander, Marta/A-1166-2013 FU Swedish Research Council; Linnaeus Grant; Acta-Otolaryngologica Foundation; Region Skane Funds for Clinical Research FX From the Departments of Otorhinolaryngology (Lindberg), Diagnostic Radiology (Siemund), and Oncology (K. Svanberg), University Hospital Lund, and the Division of Atomic Physics, Lund University (Lewander, Svensson, S. Svanberg), Lund, Sweden. Supported by a direct grant from the Swedish Research Council, a Linnaeus Grant to the Lund Laser Centre, the Acta-Otolaryngologica Foundation, and Region Skane Funds for Clinical Research. CR Andersson M, 2006, OPT EXPRESS, V14, P3641, DOI 10.1364/OE.14.003641 AOKI K, 1990, ACTA OTO-LARYNGOL, V110, P399 Aoki K, 1998, LARYNGOSCOPE, V108, P1840, DOI 10.1097/00005537-199812000-00014 DIAMANT M, 1958, Acta Otolaryngol, V49, P381, DOI 10.3109/00016485809134768 Hasebe S, 2001, ORL J OTO-RHINO-LARY, V63, P160, DOI 10.1159/000055733 HERGILS L, 1990, ACTA OTO-LARYNGOL, V110, P92, DOI 10.3109/00016489009122520 Hergils L, 1997, ANN OTO RHINOL LARYN, V106, P743 HERGILS L, 1985, ARCH OTOLARYNGOL, V111, P86 Ikarashi F, 2008, ACTA OTO-LARYNGOL, V128, P9, DOI 10.1080/00016480701200269 Lewander M, 2008, APPL PHYS B-LASERS O, V93, P619, DOI 10.1007/s00340-008-3192-2 Lewander M, 2009, OPT EXPRESS, V17, P10849, DOI 10.1364/OE.17.010849 Lewander M, RHINOLOGY IN PRESS LINDEMAN P, 1980, LARYNGOSCOPE, V90, P1840, DOI 10.1288/00005537-198011000-00012 Lund Valerie J., 1993, Rhinology (Utrecht), V31, P183 BLAND JM, 1986, LANCET, V1, P307 NAKANO Y, 1990, ACTA OTO-LARYNGOL, P56 Persson L, 2006, APPL PHYS B-LASERS O, V82, P313, DOI 10.1007/s00340-005-1968-1 Persson L, 2008, APPL OPTICS, V47, P2028, DOI 10.1364/AO.47.002028 Persson L, 2007, J BIOMED OPT, V12, DOI 10.1117/1.2777189 ROBINSON PJ, 1993, INT J PEDIATR OTORHI, V25, P13, DOI 10.1016/0165-5876(93)90005-N Sjoholm M, 2001, OPT LETT, V26, P16, DOI 10.1364/OL.26.000016 Tideholm B, 1999, ACTA OTO-LARYNGOL, V119, P880 Uzun C, 2005, OTOL NEUROTOL, V26, P59, DOI 10.1097/00129492-200501000-00010 NR 23 TC 5 Z9 5 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD APR PY 2012 VL 121 IS 4 BP 217 EP 223 PN 1 PG 7 WC Otorhinolaryngology SC Otorhinolaryngology GA 927BQ UT WOS:000302882300001 PM 22606924 ER PT J AU Burns, JA Friedman, AD Lutch, MJ Zeitels, SM AF Burns, James A. Friedman, Aaron D. Lutch, Matthew J. Zeitels, Steven M. TI Subepithelial Vocal Fold Infusion: A Useful Diagnostic and Therapeutic Technique SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article; Proceedings Paper CT Meeting of the American-Broncho-Esophagological-Association CY APR 27-28, 2011 CL Chicago, IL SP Amer Broncho Esophagol Assoc DE microlaryngoscopy; subepithelial infusion; vocal fold ID CHORIOALLANTOIC MEMBRANE; LASER TREATMENT; SURGERY; LARYNX; MODEL AB Objectives: Preservation of the maximum amount of subepithelial superficial lamina propria (SLP) remains an important goal during microlaryngoscopic surgery of phonatory mucosa. Volume expansion of the SLP (Reinke's space) with subepithelial infusion of saline solution has been widely adopted since its introduction in 1991. This technique has evolved so that it is currently used to assist with determining the depth of vocal fold disease, defining residual pliable SLP, enhancing microsurgical precision, and identifying unrecognized disease. The purpose of this investigation was to examine the indications, methods, and benefits of subepithelial infusion of saline solution as an adjunct technique during phonomicrosurgery. Methods: In a prospective case series, we collected data on 280 consecutive microlaryngoscopy procedures performed over a 12-month period. Subepithelial infusion of saline solution was included in 178 procedures. Results: New disease was identified in 20 of the 178 patients (scar in 15, sulcus in 4, and a mucosal bridge in 1). The depth of needle placement varied depending on the specific disease: 118 of the 178 infusions were done just below the epithelial basement membrane, and 60 infusions were performed deeper within the SLP, just superficial to the vocal ligament. The infusion technique provided surgical assistance in multiple ways, including identifying residual SLP (130 patients), defining the SLP-lesion interface (65 patients), lifting scar (60 patients), providing tension for cordotomy (47 patients), expanding the SLP volume to protect against laser damage (45 patients), and providing hydrostatic compression of vascular ectasias or varices for photoangiolysis (7 patients). The microlaryngoscopy procedures during which infusion was not performed (102 of 280 procedures) were primarily for nonglottic cancer (46 patients), stenosis (30 patients), or arytenoid granuloma (13 patients). Conclusions: Subepithelial infusion of the SLP with saline solution is a useful microsurgical adjunct during diagnosis and treatment of phonatory mucosal lesions. C1 [Burns, James A.; Friedman, Aaron D.; Zeitels, Steven M.] Massachusetts Gen Hosp, Ctr Laryngeal Surg & Voice Rehabil, Boston, MA 02114 USA. [Burns, James A.; Friedman, Aaron D.; Zeitels, Steven M.] Harvard Univ, Sch Med, Dept Surg, Boston, MA 02115 USA. [Lutch, Matthew J.] Kaiser Permanente, So Calif Permanente Med Grp, Dept Head & Neck Surg, San Diego, CA USA. RP Burns, JA (reprint author), Massachusetts Gen Hosp, Ctr Laryngeal Surg & Voice Rehabil, 1 Bowdoin Sq,11th Floor, Boston, MA 02114 USA. CR Broadhurst MS, 2007, LARYNGOSCOPE, V117, P220, DOI 10.1097/mlg.0b013e31802b5c1c Burns JA, 2009, LARYNGOSCOPE, V119, P419, DOI 10.1002/lary.20001 Burns JA, 2007, LARYNGOSCOPE, V117, P1500, DOI 10.1097/MLG.0b013e318064e869 Burns JA, 2010, ANN OTO RHINOL LARYN, V119, P684 Burns JA, 2008, LARYNGOSCOPE, V118, P1109, DOI 10.1097/MLG.0b013e31816902bb Dailey SH, 2007, J VOICE, V21, P112, DOI 10.1016/j.jvoice.2005.09.006 Franco RA, 2003, ANN OTO RHINOL LARYN, V112, P751 GRAY SD, 1995, ANN OTO RHINOL LARYN, V104, P13 Gray SD, 1989, VOCAL FOLD PHYSL ACO, P21 Hajek M, 1891, ARCH KLIN CHIR, V42, P46 Hirano M., 1975, OTOLOGIA FUKUOKA S1, V21, P239 Hirano M., 1977, DYNAMIC ASPECTS SPEE, P13 Hirano M, 1991, PHONOSURGERY ASSESSM, P25 Isshiki N, 1989, PHONOSURGERY THEORY Kass ES, 1996, ANN OTO RHINOL LARYN, V105, P341 PRESSMAN J, 1956, Ann Otol Rhinol Laryngol, V65, P963 PRESSMAN J J, 1960, Trans Am Acad Ophthalmol Otolaryngol, V64, P628 Reinke F, 1897, ANAT HEFTE, V9, P103 WELSH LW, 1983, ANN OTO RHINOL LARYN, V92, P19 Zeitels SM, 2001, ATLAS PHONOMICROSURG, P177 Zeitels SM., 1993, OPERATIVE TECHNIQUES, V4, P218 Zeitels SM, 1995, LARYNGOSCOPE S, V105, P1 Zeitels SM, 2008, ANN OTOL RHINOL S199, V117, P1 ZEITELS SM, 1991, OTOLARYNG HEAD NECK, V105, P478 NR 24 TC 3 Z9 3 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD APR PY 2012 VL 121 IS 4 BP 224 EP 230 PN 1 PG 7 WC Otorhinolaryngology SC Otorhinolaryngology GA 927BQ UT WOS:000302882300002 PM 22606925 ER PT J AU Mendelsohn, AH Berke, GS AF Mendelsohn, Abie H. Berke, Gerald S. TI Surgery or Botulinum Toxin for Adductor Spasmodic Dysphonia: A Comparative Study SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article; Proceedings Paper CT Meeting of the American-Broncho-Esophagological-Association CY APR 27-28, 2011 CL Chicago, IL SP Amer Broncho Esophagol Assoc DE adductor spasmodic dysphonia; botulinum toxin; hyperkinetic dysphonia; laryngeal dystonia; larynx; neurologic voice disorder; surgery; voice ID QUALITY-OF-LIFE; DENERVATION-REINNERVATION; FOLLOW-UP; INJECTION; THYROPLASTY; EXPERIENCE; MANAGEMENT; DYSTONIA AB Objectives: Currently, botulinum toxin (Botox) injection is the standard of treatment or adductor spasmodic dysphonia (ADSD). We sought to compare the outcome of selective laryngeal adductor denervation-reinnervation (SLAD-R) surgery for ADSD to that of Botox injections. Methods: Patient-oriented measures (VHI-10) and objective single-blinded gradings of digital voice recordings were utilized as outcome measures. The surgical cohort, recruited by retrospective patient selection, consisted of 77 patients with a mean follow-up time of 7.54 +/- 2.55 years (range, 2.2 to 14.2 years). The injection cohort, recruited prospectively, included 28 patients with a mean follow-up time of 46.37 +/- 5.51 days (range, 36 to 54 days). Results: As measured by the VHI-10, the surgical patients had significantly improved voice handicap outcome scores (mean, 14.4 +/- 13.6) as compared to the patients who had Botox injection (mean, 26.5 +/- 12.1; p = 0.001). Aside from VHI-10 item 2, the surgical group demonstrated significantly improved voice-related function on each VHI-10 component (p = 0.01). Within the injection subgroup, 88% agreed that Botox successfully treats their ADSD, yet only 63% agreed that Botox improves their speech consistently. Within the surgical subgroup, 82% would recommend this surgery to others, and 78% agreed that their voice was actually better after surgery than after Botox. Objective voice ratings demonstrated similar levels of breathiness and overall voice quality in the treatment subgroups. Conclusions: When indicated, the SLAD-R surgery for ADSD demonstrates outcomes equal to or superior to those of the current standard of Botox injections. C1 [Mendelsohn, Abie H.; Berke, Gerald S.] Univ Calif Los Angeles, David Geffen Sch Med, Dept Otolaryngol Head & Neck Surg, Los Angeles, CA 90095 USA. RP Berke, GS (reprint author), Univ Calif Los Angeles, David Geffen Sch Med, Dept Otolaryngol Head & Neck Surg, 10833 Le Conte Ave,62-132 CHS, Los Angeles, CA 90095 USA. CR Berke GS, 1999, ANN OTO RHINOL LARYN, V108, P227 Bhattacharyya N, 2001, ARCH OTOLARYNGOL, V127, P389 Blitzer A, 1998, LARYNGOSCOPE, V108, P1435, DOI 10.1097/00005537-199810000-00003 Blitzer A, 2010, EUR J NEUROL, V17, P28, DOI 10.1111/j.1468-1331.2010.03047.x Cannito MP, 2004, ARCH OTOLARYNGOL, V130, P1393, DOI 10.1001/archotol.130.12.1393 Chan SW, 2004, LARYNGOSCOPE, V114, P1604, DOI 10.1097/00005537-200409000-00019 Chhetri DK, 2008, ANN OTO RHINOL LARYN, V117, P159 Chhetri DK, 2006, LARYNGOSCOPE, V116, P635, DOI 10.1097/01.MLG.0000201990.97955.E4 DEDO HH, 1991, ANN OTO RHINOL LARYN, V100, P274 GREEN DC, 1992, ANN OTO RHINOL LARYN, V101, P883 Hillenbrand JM, 2005, J SPEECH LANG HEAR R, V48, P45, DOI 10.1044/1092-4388(2005/005) Ludlow CL, 2008, OTOLARYNG HEAD NECK, V139, P495, DOI 10.1016/j.otohns.2008.05.624 Morzaria S.DamroseEJ, 2010, J VOICE 1015 MURRY T, 1995, J VOICE, V9, P460, DOI 10.1016/S0892-1997(05)80211-5 Novakovic D, 2011, LARYNGOSCOPE, V121, P606, DOI 10.1002/lary.21395 Paniello RC, 2008, LARYNGOSCOPE, V118, P564, DOI 10.1097/MLG.0b013e31815e8be0 Rosen CA, 2004, LARYNGOSCOPE, V114, P1549, DOI 10.1097/00005537-200409000-00009 Shaw GY, 2003, ANN OTO RHINOL LARYN, V112, P303 Silverman EP, 2011, J VOICE 0202 SODERSTEN M, 1995, J VOICE, V9, P182, DOI 10.1016/S0892-1997(05)80252-8 Troung D D, 1991, Laryngoscope, V101, P630 Venkatesan NN, 2010, LARYNGOSCOPE, V120, P1177, DOI 10.1002/lary.20855 NR 22 TC 1 Z9 1 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD APR PY 2012 VL 121 IS 4 BP 231 EP 238 PN 1 PG 8 WC Otorhinolaryngology SC Otorhinolaryngology GA 927BQ UT WOS:000302882300003 PM 22606926 ER PT J AU Cho, GS Kim, JH Jang, YJ AF Cho, Gye Song Kim, Jeoung Hyun Jang, Yong Ju TI Correlation of Nasal Obstruction With Nasal Cross-Sectional Area Measured by Computed Tomography in Patients With Nasal Septal Deviation SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE computed tomography; deviated nasal septum; nasal obstruction; visual analog scale ID COMPUTATIONAL FLUID-DYNAMICS; ACOUSTIC RHINOMETRY; CAVITY; AIRWAY; RHINOMANOMETRY; SEPTOPLASTY; EMPHYSEMA; DIAGNOSIS; SURGERY; PATENCY AB Objectives: The objective of the present study was to investigate the relationship between the subjective sensation of nasal obstruction and the corresponding cross-sectional area for nasal airflow in patients with a deviated septum. Methods: Seventy-one patients with a diagnosis of unilateral nasal obstruction due to a deviated nasal septum were evaluated by preoperative computed tomography. Anterior anatomic characteristics (the internal nasal valve angle and the cross-sectional areas at the external nasal valve, the head of the inferior turbinate, and the head of the middle turbinate) and posterior anatomic factors (the cross-sectional areas at the openings of the frontal sinus, maxillary sinus, and end of the nasal septum) were examined. Associations between the computed tomography measurements and the subjective severity of nasal obstruction were analyzed with a visual analog scale (VAS). Results: Anterior and posterior anatomic characteristics were associated with the subjective severity of nasal obstruction. Anterior anatomic factors were related to the VAS scores of patients with anterior septal deviation, and posterior anatomic factors were related to the VAS scores of patients with posterior septal deviation. Conclusions: This study indicated that the anterior and posterior parts of the nasal cavity are both related to nasal obstruction. In some patients, the posterior part of the nasal cavity was more important than other locations in causing nasal obstruction. C1 [Cho, Gye Song; Jang, Yong Ju] Univ Ulsan, Coll Med, Asan Med Ctr, Dept Otolaryngol, Seoul 138736, South Korea. [Kim, Jeoung Hyun] Kyung Hee Univ Gangdong, Dept Radiol, Seoul, South Korea. RP Jang, YJ (reprint author), Univ Ulsan, Coll Med, Asan Med Ctr, Dept Otolaryngol, 388-1 Pungnap 2 Dong, Seoul 138736, South Korea. CR BRIDGER GP, 1970, ARCHIV OTOLARYNGOL, V92, P543 Cankurtaran M, 2007, ANN OTO RHINOL LARYN, V116, P906 Chaban R, 1998, ARCH OTOLARYNGOL, V114, P413 Chandra RK, 2009, OTOLARYNG CLIN N AM, V42, P207, DOI 10.1016/j.otc.2009.01.004 Clarke JD, 2006, AM J RHINOL, V20, P20 Garcia GJM, 2010, AM J RHINOL ALLERGY, V24, pE46, DOI 10.2500/ajra.2010.24.3428 GEVENOIS PA, 1995, AM J RESP CRIT CARE, V152, P653 GRYMER L F, 1991, Rhinology (Utrecht), V29, P35 GRYMER LF, 1989, LARYNGOSCOPE, V99, P1180 Hirschberg A, 1998, ORL J OTO-RHINO-LARY, V60, P206, DOI 10.1159/000027595 Lam DJ, 2006, AM J RHINOL, V20, P463, DOI 10.2500/ajr.2006.20.2940 Lee HP, 2009, AMJ RHINOL ALLERGY, V23, P153, DOI 10.2500/ajra.2009.23.3287 Lee YK, 2008, LUNG, V186, P277, DOI 10.1007/s00408-008-9097-3 Lee YK, 2008, LUNG, V186, P157, DOI 10.1007/s00408-008-9071-0 MIN YG, 1995, LARYNGOSCOPE, V105, P757, DOI 10.1288/00005537-199507000-00014 Naito K, 2001, EUR ARCH OTO-RHINO-L, V258, P505, DOI 10.1007/s004050100360 Ozlugedik S, 2008, LARYNGOSCOPE, V118, P330, DOI 10.1097/MLG.0b013e318159aa26 Pirila T, 2009, AMJ RHINOL ALLERGY, V23, P605, DOI 10.2500/ajra.2009.23.3372 ROITHMANN R, 1994, J OTOLARYNGOL, V23, P454 Stewart MG, 2004, OTOLARYNG HEAD NECK, V130, P157, DOI 10.1016/j.otohns.2003.09.016 Wexler D, 2005, ARCH OTOLARYNGOL, V131, P1102, DOI 10.1001/archotol.131.12.1102 Wittkopf M, 2008, CURR OPIN OTOLARYNGO, V16, P10, DOI 10.1097/MOO.0b013e3282f396ef NR 22 TC 3 Z9 3 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD APR PY 2012 VL 121 IS 4 BP 239 EP 245 PN 1 PG 7 WC Otorhinolaryngology SC Otorhinolaryngology GA 927BQ UT WOS:000302882300004 PM 22606927 ER PT J AU Vimercati, SL Rigoldi, C Albertini, G Crivellini, M Galli, M AF Vimercati, Sara Laura Rigoldi, Chiara Albertini, Giorgio Crivellini, Marcello Galli, Manuela TI Quantitative Evaluation of Facial Movement and Morphology SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE facial impairment; optoelectronic system; oral dyspraxia ID PARKINSONS-DISEASE; GRADING SYSTEMS; QUANTIFICATION; MOTION; ASYMMETRY; MOUTH AB Objectives: The aim of our study was to quantitatively analyze facial motion kinematics by means of an optoelectronic system. In particular, we defined a set of easily recognizable reference points for markerization, and tested the applicability of our markerization method for an exhaustive characterization of the subjects' facial motion through the definition of some kinematic parameters. Methods: Thirty healthy subjects (mean age, 24.6 +/- 1.0 years; 15 female and 15 male) participated in the study. A set of markers (diameter, 3 mm) was positioned on several reference points of the face, and some parameters were computed for the characterization of facial morphology and movement, such as ranges of motion, angles, times, and distances. Results: The protocol was tested for inter-rater and intra-rater reliability by use of intraclass correlation, of which the results were good (between 0.4 and 0.75) to excellent (greater than 0.75). The parameters were useful for characterizing the resting position, mimicry, and speaking movements, and highlighted some distinctions between men and women in facial morphology. Conclusions: The protocol can be applied to a variety of facial movements, including speaking. Future works could address the use of the protocol in subjects with disorders and the integrated analysis of kinematic parameters and voice spectrography. C1 [Vimercati, Sara Laura; Rigoldi, Chiara; Crivellini, Marcello; Galli, Manuela] Politecn Milan, Dept Bioengn, I-20133 Milan, Italy. [Albertini, Giorgio; Galli, Manuela] IRCCS San Raffaele Pisana, Rome, Italy. RP Vimercati, SL (reprint author), Politecn Milan, Dept Bioengn, Pzza Leonardo Da Vinci 32, I-20133 Milan, Italy. CR Bastiaanse R, 2009, CORTEX, V45, P912, DOI 10.1016/j.cortex.2009.03.011 Chen CL, 2010, J NEUROENG REHABIL, V7, DOI 10.1186/1743-0003-7-54 Coulson SE, 2000, ANN OTO RHINOL LARYN, V109, P478 Ferrario VF, 2005, ARCH ORAL BIOL, V50, P507, DOI 10.1016/j.archoralbio.2004.10.002 He S, 2009, IEEE T BIO-MED ENG, V56, P1864, DOI 10.1109/TBME.2009.2017508 Hontanilla B, 2008, J PLAST RECONSTR AES, V61, P18, DOI 10.1016/j.bjps.2007.03.037 HOUSE JW, 1983, LARYNGOSCOPE, V93, P1056 Lin SC, 2000, J FORMOS MED ASSOC, V99, P393 Linstrom CJ, 2002, LARYNGOSCOPE, V112, P1129, DOI 10.1097/00005537-200207000-00001 Nakata S, 2006, OTOL NEUROTOL, V27, P1023, DOI 10.1097/01.mao.0000231597.95466.d6 Okamoto H, 2010, ANGLE ORTHOD, V80, P223, DOI 10.2319/021809-104.1 RAS F, 1995, ANGLE ORTHOD, V65, P233 SHROUT PE, 1979, PSYCHOL BULL, V86, P420, DOI 10.1037//0033-2909.86.2.420 SMITH IM, 1992, CLIN OTOLARYNGOL, V17, P303, DOI 10.1111/j.1365-2273.1992.tb01001.x Uluduz D, 2010, EUR J NEUROL, V17, P413, DOI 10.1111/j.1468-1331.2009.02905.x NR 15 TC 0 Z9 0 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD APR PY 2012 VL 121 IS 4 BP 246 EP 252 PN 1 PG 7 WC Otorhinolaryngology SC Otorhinolaryngology GA 927BQ UT WOS:000302882300005 PM 22606928 ER PT J AU Di Berardino, F Forti, S Cesarani, A AF Di Berardino, Federica Forti, Stella Cesarani, Antonio TI VTMR, a New Speech Audiometry Test With Verbal Tasks and Motor Responses SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE comprehension; hearing loss; speech audiometry ID IN-NOISE TEST; THRESHOLDS; HEARING; RECOGNITION; WORDS; QUIET AB Objectives: The aim of this study was to design a complementary speech audiometry test using verbal tasks and motor responses (VTMR) to assess the ability of a subject to understand and perform simple motor tasks with 3-dimensional objects, to describe its construction, and to show the preliminary results of a pilot study on the Italian version of the test. Methods: The items used in the test setting included I base, I hammer, I wooden structure with 4 sticks, and 5 rings of different colors and 20 lists with 5 verbal tasks per list. The VTMR test and bisyllabic speech audiometry were evaluated in normal-hearing subjects with and without cognitive impairment and in subjects with sensorineural hearing loss. Results: All normal-hearing subjects without cognitive impairment performed the VTMR. tasks (100%) correctly at 35 dB sound pressure level. In subjects with sensorineural hearing loss, the percentage of correct answers was significantly higher for the VTMR test than for bisyllabic speech audiometry above 50 dB sound pressure level. This percentage was higher for the VTMR also in normal-hearing subjects with poor cognitive skills. Conclusions: The VTMR might make it easier to check patients' ability to understand verbal commands than does traditional speech audiometry, in particular in those patients with poor test-taking skills. C1 [Di Berardino, Federica; Cesarani, Antonio] Univ Milan, Dipartimento Sci Chirurg Specialist, Milan, Italy. [Forti, Stella; Cesarani, Antonio] Fdn IRCCS Ca Granda Osped Maggiore Policlin, Audiol Unit, Milan, Italy. RP Di Berardino, F (reprint author), Viale Piceno 14, I-20129 Milan, Italy. EM federica.diberardino@unimi.it CR American Academy of Otolaryngology Committee on Hearing and Equilibrium; American Council of Otolaryngology Committee on the Medical Aspects of Noise, 1979, OTOLARYNGOL HEAD NEC, V87, P539 ASHA, 1988, ASHA, V30, P85 Bocca E, 1950, ARCH ITAL OTOL, V5, P116 BOCCA E, 1951, Otorinolaringol Ital, V19, P461 Brandy WT, 2002, HDB CLIN AUDIOLOGY, P96 Campbell RA, 1965, J SPEECH HEAR RES, V128, P13 Cesarani A, 2007, OTOLARYNGOLOGY DENNIS JM, 1991, OTOLARYNG CLIN N AM, V24, P253 Di Berardino F, 2010, J LARYNGOL OTOL, V124, P859, DOI 10.1017/S0022215110000782 Dronkers NF, 2004, COGNITION, V92, P145, DOI 10.1016/j.cognition.2003.11.002 Egan JP, 1944, PSYCHOACOUSTIC LAB European Committee for Standardization C, 1996, 82533 EN ISO EUR COM European Committee for Standardization C, 1992, 82522 EN ISO EUR COM Floel A, 2003, EUR J NEUROSCI, V18, P704, DOI 10.1046/j.1460-9568.2003.02774.x FOURCIN AJ, 1973, BRIT MED J, V3, P290 Gelfand S., 2001, ESSENTIALS AUDIOLOGY Hirsh IJ, 1952, J SPEECH HEAR DISORD, V17, P321 Houtgast T, 2008, INT J AUDIOL, V47, P287, DOI 10.1080/14992020802127109 Jerger J, 1992, J Am Acad Audiol, V3, P33 Jerger J, 2010, J AM ACAD AUDIOL, V21, P424, DOI 10.3766/jaaa.21.7.1 JERGER J, 1977, ARCH OTOLARYNGOL, V103, P216 Jerger J, 2000, J Am Acad Audiol, V11, P467 JERGER J, 1968, J SPEECH HEAR DISORD, V33, P318 Killion MC, 2004, J ACOUST SOC AM, V116, P2395, DOI 10.1121/1.1784440 MACKIE K, 1986, J SPEECH HEAR RES, V29, P275 MARGOLIS RH, 1971, J SPEECH HEAR RES, V14, P865 NILSSON M, 1994, J ACOUST SOC AM, V95, P1085, DOI 10.1121/1.408469 Nissen SL, 2005, INT J AUDIOL, V44, P379, DOI 10.1080/14992020500147615 Salthouse TA, 1985, THEORY COGNITIVE AGI Sherwood T, 1997, SPEECH AUDIOMETRY, P89 Speaks C, 1970, J Speech Hear Res, V13, P755 Theunissen M, 2009, INT J AUDIOL, V48, P743, DOI 10.3109/14992020903082088 Wang S, 2007, INT J AUDIOL, V46, P719, DOI 10.1080/14992020701558511 Wilson RH, 2005, J REHABIL RES DEV, V42, P79, DOI 10.1682/JRRD.2005.06.0096 Wilson RH, 2011, J AM ACAD AUDIOL, V22, P405, DOI 10.3766/jaaa.22.7.3 Wilson W J, 2000, S Afr J Commun Disord, V47, P57 Wingfield A, 1996, J Am Acad Audiol, V7, P175 YOUNG LL, 1982, J SPEECH HEAR RES, V25, P586 NR 38 TC 0 Z9 0 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD APR PY 2012 VL 121 IS 4 BP 253 EP 260 PN 1 PG 8 WC Otorhinolaryngology SC Otorhinolaryngology GA 927BQ UT WOS:000302882300006 PM 22606929 ER PT J AU Tani, A Tada, Y Takezawa, T Imaizumi, M Nomoto, Y Nakamura, T Omori, K AF Tani, Akiko Tada, Yasuhiro Takezawa, Toshiaki Imaizumi, Mitsuyoshi Nomoto, Yukio Nakamura, Tatsuo Omori, Koichi TI Regeneration of Tracheal Epithelium Using a Collagen Vitrigel-Sponge Scaffold Containing Basic Fibroblast Growth Factor SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article; Proceedings Paper CT Meeting of the American-Broncho-Esophagological-Association CY APR 27-28, 2011 CL Chicago, IL SP Amer Broncho Esophagol Assoc DE basic fibroblast growth factor; collagen vitrigel-sponge scaffold; tracheal epithelium; tracheal reconstruction ID IN-VITRO; RECONSTRUCTION; CARTILAGE; REPAIR AB Objectives: Our group has had good results in tracheal mucosal regeneration using a collagen vitrigel-sponge scaffold in an animal model. In this study, the effectiveness of this scaffold with the application of basic fibroblast growth factor (b-FGF) was investigated. Methods: A collagen vitrigel-sponge scaffold was fabricated with simultaneous addition of b-FGF. Three types of collagen vitrigel-sponge scaffolds were made: no b-FGF, 10 ng of b-FGF, and IOU 112 of b-FGF. At 3, 5, 7, and 14 days after implantation in rats, the tracheas were removed and histologically evaluated. The regeneration of mucosal epithelium and the subepithelial layer was evaluated. Results: Mucosal epithelium, including pseudostratified epithelium and ciliated cells, regenerated earlier in the scaffolds when b-FGF was applied than when b-FGF was not applied. Regeneration of the subepithelial layer, infiltration of inflammatory cells and fibroblasts, and angiogenesis were promoted earlier in the scaffolds with b-FGF application. Conclusions: Our technique for tracheal reconstruction using collagen vitrigel-sponge scaffolds with b-FGF application affords a feasible approach for accelerating the regeneration of the intraluminal surface and subepithelial layer of tracheal tissue. C1 [Tani, Akiko] Fukushima Med Univ, Sch Med, Dept Otolaryngol, Fukushima 9601295, Japan. [Takezawa, Toshiaki] Natl Inst Agrobiol Sci, Div Anim Sci, Ibaraki, Japan. [Nakamura, Tatsuo] Kyoto Univ, Inst Frontier Med Sci, Dept Bioartificial Organs, Kyoto, Japan. RP Tani, A (reprint author), Fukushima Med Univ, Sch Med, Dept Otolaryngol, 1 Hikarigaoka, Fukushima 9601295, Japan. CR BILLER HF, 1986, ANN OTO RHINOL LARYN, V95, P586 CAPUTO V, 1961, J THORAC CARDIOV SUR, V41, P594 Genden EM, 2006, ANN OTO RHINOL LARYN, V115, P302 Hirose Keiichi, 2005, Interact Cardiovasc Thorac Surg, V4, P526, DOI 10.1510/icvts.2005.114926 Igai H, 2007, J THORAC CARDIOV SUR, V134, P170, DOI 10.1016/j.jtcvs.2007.02.022 Kobayashi K, 2006, TISSUE ENG, V12, P2619, DOI 10.1089/ten.2006.12.2619 KOJIMA H, 1990, AM J OTOLARYNG, V11, P328, DOI 10.1016/0196-0709(90)90063-2 Motomura H, 2006, J DERMATOL, V33, P353, DOI 10.1111/j.1346-8138.2006.00082.x Nakamura T, 2000, INT J ARTIF ORGANS, V23, P718 Nomoto Y, 2008, ANN OTO RHINOL LARYN, V117, P59 Okumura M, 1996, BIOL PHARM BULL, V19, P530 Omori K, 2005, ANN OTO RHINOL LARYN, V114, P429 Parker NP, 2009, LARYNGOSCOPE, V119, P734, DOI 10.1002/lary.20131 Presta M, 2005, CYTOKINE GROWTH F R, V16, P159, DOI 10.1016/j.cytogfr.2005.01.004 ROBSON MC, 1992, ANN SURG, V216, P401, DOI 10.1097/00000658-199210000-00002 Suzuki T, 2008, ANN OTO RHINOL LARYN, V117, P453 TABATA Y, 1994, J CONTROL RELEASE, V31, P189, DOI 10.1016/0168-3659(94)00035-2 Tada Y, 2008, ANN OTO RHINOL LARYN, V117, P359 Takezawa T, 2004, CELL TRANSPLANT, V13, P463, DOI 10.3727/000000004783983882 Takezawa T, 2007, J BIOTECHNOL, V131, P76, DOI 10.1016/j.jbiotec.2007.05.033 NR 20 TC 4 Z9 5 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD APR PY 2012 VL 121 IS 4 BP 261 EP 268 PN 1 PG 8 WC Otorhinolaryngology SC Otorhinolaryngology GA 927BQ UT WOS:000302882300007 PM 22606930 ER PT J AU Luers, JC Stenner, M Schinke, M Helmstaedter, V Beutner, D AF Luers, Jan Christoffer Stenner, Markus Schinke, Michael Helmstaedter, Victor Beutner, Dirk TI Tolerability of Sialendoscopy Under Local Anesthesia SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE local anesthesia; salivary gland; sialendoscopy; sialolithiasis ID SALIVARY-STONES; MANAGEMENT; SIALOENDOSCOPY AB Objectives: We sought to investigate patients' tolerance of sialendoscopy of the parotid and submandibular glands with local anesthesia. Methods: In a retrospective case series of 84 adult patients who underwent sialendoscopy with local anesthesia at an academic tertiary referral hospital, we analyzed patients' demographic data, American Society of Anesthesiologists (ASA) status score, perioperative cardiovascular parameters, and results on a 2-question survey. Results: Of the 84 patients, 44 were female and 40 were male (mean age, 48.6 years). The patients had a mean ASA status score of 1.57. On average, 2.16 mL of local anesthetic was used. The mean systolic blood pressure was 137 mm Hg, and the mean diastolic blood pressure was 80 mm Hg. The duration of the procedure showed a significant correlation with the maximum systolic blood pressure (r = 0.35; p = 0.001), the mean systolic blood pressure (r = 0.25; p = 0.02), the maximum diastolic blood pressure (r = 0.37; p = 0.001), and the mean diastolic blood pressure (r = 0.31; p = 0.005). The mean heart rate was 77 beats per minute. The majority of patients considered the procedure to be tolerable. In this series, the indications for conducting sialendoscopy under general anesthesia were procedures of greater invasiveness and complex situations with multiple sialolithiases, difficult anatomic preconditions, or a very long expected operation time. Conclusions: Sialendoscopy performed with local anesthesia is well tolerated, provided that the patient has a good general health status and the operative procedure is not expected to be complex or long-lasting. C1 [Luers, Jan Christoffer; Stenner, Markus; Schinke, Michael; Beutner, Dirk] Univ Cologne, Dept Otorhinolaryngol Head & Neck Surg, D-50924 Cologne, Germany. [Helmstaedter, Victor] Univ Cologne, Dept Anesthesiol, D-50924 Cologne, Germany. RP Luers, JC (reprint author), Univ Cologne, Dept Otorhinolaryngol Head & Neck Surg, D-50924 Cologne, Germany. CR American Society of Anesthesiologists, 2010, ASA PHYS STAT CLASS Bernal-Sprekelsen M, 1992, Anesth Pain Control Dent, V1, P81 Bodenham AR, 2009, BRIT J ANAESTH, V103, P785, DOI 10.1093/bja/aep310 Broderick JE, 2006, J PAIN, V7, P142, DOI 10.1016/j.jpain.2005.09.012 Iro H, 2009, LARYNGOSCOPE, V119, P263, DOI 10.1002/lary.20008 Koch M, 2010, OTOLARYNG HEAD NECK, V142, P98, DOI 10.1016/j.otohns.2009.10.022 Luers JC, 2011, ARCH OTOLARYNGOL, V137, P325, DOI 10.1001/archoto.2010.238 Marchal F, 1999, NEW ENGL J MED, V341, P1242, DOI 10.1056/NEJM199910143411620 Marchal F, 2003, ARCH OTOLARYNGOL, V129, P951, DOI 10.1001/archotol.129.9.951 Nahlieli O, 1999, J ORAL MAXIL SURG, V57, P1394, DOI 10.1016/S0278-2391(99)90716-4 Nahlieli O, 1997, J ORAL MAXIL SURG, V55, P912, DOI 10.1016/S0278-2391(97)90056-2 STAFFORD MA, 1992, BRIT J HOSP MED, V47, P533 Walvekar RR, 2009, LARYNGOSCOPE, V119, P1125, DOI 10.1002/lary.20203 NR 13 TC 3 Z9 3 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD APR PY 2012 VL 121 IS 4 BP 269 EP 274 PN 1 PG 6 WC Otorhinolaryngology SC Otorhinolaryngology GA 927BQ UT WOS:000302882300008 PM 22606931 ER PT J AU Thomeer, HGXM Kunst, HPM Cremers, CWRJ AF Thomeer, Henricus G. X. M. Kunst, Henricus P. M. Cremers, Cor W. R. J. TI Congenital Ossicular Chain Anomalies Associated With a Mobile Stapes Footplate: Surgical Results for 23 Ears SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE conductive hearing impairment; congenital disorder; middle ear; reconstruction; surgery; syndrome ID ANCHORED HEARING-AID; MIDDLE-EAR; SURGERY; ANKYLOSIS AB Objectives: We describe the audiometric results following surgery in a consecutive series of patients with a congenital ossicular middle ear disorder that was associated with a mobile stapes footplate. Methods: We performed a retrospective analysis of patient charts from a tertiary referral center. A total of 23 patients (23 ears) underwent exploratory tympanotomy and ossicular reconstruction between 1986 and 2001. The main outcome measure was the audiometric results. Results: Overall, we observed a mean gain in air conduction pure tone average of 17 dB (from 47 dB to 30 dB), a sensorineural deterioration of 3 dB, and a mean postoperative air-bone gap of 19 dB (mean preoperative air-bone gap of 38 dB). The air-bone gap closure was 20 dB or less in 15 of the 23 cases (65%), in agreement with the few results reported in the literature. Moreover, the audiometric results remained stable. In the syndromic group, the mean gain in air conduction was only 13 dB, which was worse than that observed for the nonsyndromic ears. Conclusions: Surgery for congenital ossicular chain anomalies with a concomitant mobile stapes footplate provides positive audiometric outcomes. Most ears had some sensorineural impairment (10 to 20 dB), which influenced the final hearing level attained after surgery. Preoperative assessment is mandatory to search for syndromal diagnoses, which might be important for patient counseling and prognosis. C1 [Thomeer, Henricus G. X. M.] Radboud Univ Nijmegen, Med Ctr, Dept Otorhinolaryngol, Donders Inst Neurosci, NL-6500 HB Nijmegen, Netherlands. Radboud Univ Nijmegen, Med Ctr, Donders Ctr Brain Cognit & Behav, NL-6500 HB Nijmegen, Netherlands. RP Thomeer, HGXM (reprint author), Radboud Univ Nijmegen, Med Ctr, Dept Otorhinolaryngol, Donders Inst Neurosci, POB 9101, NL-6500 HB Nijmegen, Netherlands. RI Kunst, Henricus/J-6456-2012 CR Charachon R, 1994, Ann Otolaryngol Chir Cervicofac, V111, P69 Committee on Hearing and Equilibrium. Committee on Hearing and Equilibrium guidelines for the evaluation of results of treatment of conductive hearing loss. American Academy of OtolaryngologyY Head and Neck Surgery Foundation Inc, 1995, OTOLARYNGOL HEAD NEC, V113, P186 COUSINS VC, 1988, AM J OTOL, V9, P76 Cremers C W, 1988, Adv Otorhinolaryngol, V40, P9 CREMERS CWRJ, 1981, ORL J OTO-RHINO-LARY, V43, P223 CREMERS CWRJ, 1992, INT J PEDIATR OTORHI, V23, P81, DOI 10.1016/0165-5876(92)90082-Z CREMERS CWRJ, 1991, INT J PEDIATR OTORHI, V22, P59, DOI 10.1016/0165-5876(91)90097-U de Bruijn AJG, 2001, OTOLARYNG HEAD NECK, V124, P84, DOI 10.1067/mhn.2001.111600 Declau F, 2007, PEDIAT ENT, P361 Dun CAJ, 2011, ADV OTO-RHINO-LARYNG, V71, P22, DOI 10.1159/000323577 Ensink RJH, 1997, GENET COUNSEL, V8, P285 FUNASAKA S, 1979, ARCH OTO-RHINO-LARYN, V224, P231, DOI 10.1007/BF01108781 Gorlin R.J., 1995, HEREDITARY HEARING L HENNER R, 1956, Laryngoscope, V66, P526 HOUGH J V, 1958, Laryngoscope, V68, P1337, DOI 10.1288/00005537-195808000-00001 Kemperman MH, 2001, OTOL NEUROTOL, V22, P637, DOI 10.1097/00129492-200109000-00014 Kisilevsky VE, 2009, INT J PEDIATR OTORHI, V73, P1712, DOI 10.1016/j.ijporl.2009.09.005 Desaulty A, 1990, Ann Otolaryngol Chir Cervicofac, V107, P7 MANOLIDI.L, 1972, HNO-WEGW FACHARZT PR, V20, P176 Marres H A, 1995, Rev Laryngol Otol Rhinol (Bord), V116, P105 MARRES HAM, 1995, ANN OTO RHINOL LARYN, V104, P31 OMBREDANNE M, 1964, Ann Otolaryngol Chir Cervicofac, V81, P201 OMBREDANNE M, 1959, Ann Otolaryngol, V76, P425 Ombredanne M, 1966, Ann Otolaryngol Chir Cervicofac, V83, P273 Ombredanne M, 1962, ANN OTOLARYNGOL PARI, V79, P637 OMBREDANNE M, 1960, Ann Otolaryngol, V77, P423 Ombrédanne M, 1966, Acta Otorhinolaryngol Belg, V20, P623 Ombredanne M, 1968, Ann Otolaryngol Chir Cervicofac, V85, P369 OMBREDANNE M, 1962, Ann Otolaryngol, V79, P485 Park K, 2009, ACTA OTO-LARYNGOL, V129, P419, DOI 10.1080/00016480802587846 Sakamoto T, 2011, ORL-J OTO-RHIN-LARYN, V73, P61, DOI 10.1159/000323010 Snik A, 2008, INT J AUDIOL, V47, P554, DOI 10.1080/14992020802307354 TEUNISSEN B, 1990, LARYNGOSCOPE, V100, P1331 TEUNISSEN B, 1991, INT J PEDIATR OTORHI, V21, P217, DOI 10.1016/0165-5876(91)90003-T TEUNISSEN E, 1993, EUR ARCH OTO-RHINO-L, V250, P327 TEUNISSEN EB, 1993, ANN OTO RHINOL LARYN, V102, P606 Thomeer HGXM, 2010, ANN OTO RHINOL LARYN, V119, P761 Tos M, 2000, SURG SOLUTIONS CONDU, V4, P212 Wehrs RE, 1999, LARYNGOSCOPE, V109, P192, DOI 10.1097/00005537-199902000-00004 NR 39 TC 3 Z9 3 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD APR PY 2012 VL 121 IS 4 BP 275 EP 281 PN 1 PG 7 WC Otorhinolaryngology SC Otorhinolaryngology GA 927BQ UT WOS:000302882300009 PM 22606932 ER PT J AU Berzofsky, CE Holiday, RA Pitman, MJ AF Berzofsky, Craig E. Holiday, Roy A. Pitman, Michael J. TI Variability of Postoperative Esophagrams After Endoscopic Cricopharyngeal Myotomy: Technique Dependence SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE cricopharyngeal achalasia; cricopharyngeal dysfunction; dysphagia; endoscopic cricopharyngeal myotomy; radiology ID FIBRIN GLUE; MANAGEMENT; INJECTION; SURGERY AB Objectives: We illustrate the dependence of postoperative day (POD) 1 esophagram findings on the closure technique used after endoscopic cricopharyngeal myotomy (ECPM). Methods: We performed a retrospective chart review of POD 1 fluoroscopic examinations of the cervical esophagus utilizing contrast dye after ECPM to assess radiologic findings associated with three different techniques of addressing the exposed buccopharyngeal fascia (BPF). Results: Each technique resulted in specific and different findings on the POD 1 esophagram. When the BPF was untreated, the esophagram demonstrated a pseudodiverticulum with free flow of contrast dye. When a fibrin glue seal was used, the esophagram demonstrated a curvilinear focus of contrast dye projected over the retropharyngeal soft tissue persisting after the swallow, similar to a leak. When fibrin glue application was combined with single-suture reapproximation of the mucosal incision, the pattern was similar to esophagrams performed 6 weeks after myotomy. Conclusions: Different techniques used to address the exposed BPF following ECPM result in specific findings on the POD 1 esophagram. Recognition of these imaging differences and open communication with the fluoroscopist will avoid a misdiagnosis of a pharyngeal leak, which might cause an unnecessary delay of oral feeding and hospital discharge. C1 [Berzofsky, Craig E.; Pitman, Michael J.] New York Eye & Ear Infirm, Dept Otolaryngol, Voice & Swallowing Inst, New York, NY 10003 USA. [Holiday, Roy A.] New York Eye & Ear Infirm, Dept Radiol, New York, NY 10003 USA. RP Pitman, MJ (reprint author), New York Eye & Ear Infirm, Dept Otolaryngol, Voice & Swallowing Inst, 310 E 14th St,6th Floor, New York, NY 10003 USA. CR Choi YY, 2011, AM SURGEON, V77, P376 HERBERHOLD C, 1995, ADV OTO-RHINO-LARYNG, V49, P144 Joch C, 2003, CARDIOVASC SURG, V11, P23, DOI 10.1016/S0967-2109(03)00068-1 Kanazawa R, 2010, NEUROL MED-CHIR, V50, P608 KAPLAN S, 1951, ANN SURG, V133, P572, DOI 10.1097/00000658-195113340-00021 Kawamura M, 2002, ANN THORAC SURG, V73, P1098, DOI 10.1016/S0003-4975(02)03415-X Lawson Georges, 2006, Curr Opin Otolaryngol Head Neck Surg, V14, P437, DOI 10.1097/MOO.0b013e3280106314 Lim R Y, 1995, J Clin Laser Med Surg, V13, P241 Pitman M, 2009, LARYNGOSCOPE, V119, P45, DOI 10.1002/lary.20032 Rabago LR, 2002, ENDOSCOPY, V34, P632, DOI 10.1055/s-2002-33237 Schievink WI, 2008, NEUROLOGY, V70, P885, DOI 10.1212/01.wnl.0000265400.54810.13 Sivarao D. V., 2000, American Journal of Medicine, V108, p27S Takes RP, 2005, HEAD NECK-J SCI SPEC, V27, P703, DOI 10.1002/hed.20201 Takeuchi H, 1996, J AM ASSOC GYN LAP, V3, P575, DOI 10.1016/S1074-3804(96)80033-8 NR 14 TC 0 Z9 0 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD MAR PY 2012 VL 121 IS 3 BP 145 EP 150 PG 6 WC Otorhinolaryngology SC Otorhinolaryngology GA 911CP UT WOS:000301695200001 PM 22530472 ER PT J AU Francis, DO Blumin, J Merati, A AF Francis, David O. Blumin, Joel Merati, Albert TI Reducing Fistula Rates Following Laryngotracheal Separation SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article; Proceedings Paper CT Meeting of the American-Broncho-Esophagological-Association CY APR 27-28, 2011 CL Chicago, IL SP Amer Broncho Esophagol Assoc DE amyotrophic lateral sclerosis; aspiration; laryngotracheal separation; larynx; surgery ID INTRACTABLE ASPIRATION; SURGERY; CHILDREN; LARYNX AB Objectives: Laryngotracheal separation (LTS) is an uncommonly performed but highly effective procedure for intractable aspiration in patients with amyotrophic lateral sclerosis and other neurodegenerative conditions. Previously published series have noted rates of postoperative tracheocutaneous fistula formation as high as I in 3 patients. This report details the use of a muscle flap reinforced imbrication technique to reduce the incidence of fistula formation after LTS surgery. Methods: All patients who underwent LTS surgery at the reporting institutions between 2004 and 2010 were identified. The principal diagnosis, patient characteristics, the presence of a preexisting tracheotomy, and postoperative complications were recorded. We describe the technique for imbrication closure of the proximal stump with strap muscle reinforcement. Results: Thirteen patients (10 male, 3 female; median age, 53 years; interquartile range, 45 to 66 years) underwent the LTS procedure; amyotrophic lateral sclerosis was the principal diagnosis in 8 of the 13 patients. Six patients had a preexisting tracheotomy. None developed tracheocutaneous fistula, hematoma, or wound infection. Two patients required stomaplasty at a later date. Conclusions: Strap muscle flap reinforced imbrication closure of the proximal tracheal stump after LTS surgery allows for a low incidence of postoperative fistula formation. C1 [Merati, Albert] Univ Washington, Sch Med, Dept Otolaryngol Head & Neck Surg, Seattle, WA 98195 USA. [Francis, David O.] Vanderbilt Univ, Dept Otolaryngol, Nashville, TN USA. [Blumin, Joel] Med Coll Wisconsin, Dept Otolaryngol, Milwaukee, WI 53226 USA. RP Merati, A (reprint author), Univ Washington, Sch Med, Dept Otolaryngol Head & Neck Surg, Box 356515,1959 NE Pacific St, Seattle, WA 98195 USA. CR Aviv JE, 1996, ANN OTO RHINOL LARYN, V105, P92 BARON BC, 1980, LARYNGOSCOPE, V90, P1927, DOI 10.1288/00005537-198012000-00002 Cook SP, 2009, LARYNGOSCOPE, V119, P390, DOI 10.1002/lary.20044 EIBLING DE, 1995, LARYNGOSCOPE, V105, P83, DOI 10.1288/00005537-199501000-00018 EISELE DW, 1988, ANN OTO RHINOL LARYN, V97, P471 LINDEMAN RC, 1975, LARYNGOSCOPE, V85, P157, DOI 10.1288/00005537-197501000-00012 Manrique D, 2006, DYSPHAGIA, V21, P254, DOI 10.1007/s00455-006-9048-1 Merati AL, 2006, TXB LARYNGOLOGY, P377 MONTGOMERY WW, 1975, ARCH OTOLARYNGOL, V101, P679 SNYDERMAN CH, 1988, ANN OTO RHINOL LARYN, V97, P466 Sorenson EJ, 2007, AMYOTROPH LATERAL SC, V8, P87, DOI 10.1080/17482960601147461 Suzuki H, 2009, EUR ARCH OTO-RHINO-L, V266, P1279, DOI 10.1007/s00405-009-0942-7 Takano Y, 1999, CHEST, V116, P1251, DOI 10.1378/chest.116.5.1251 Watanabe K, 2011, AM J OTOLARYNG, V32, P156, DOI 10.1016/j.amjoto.2009.10.003 WAX MK, 1995, OTOLARYNG HEAD NECK, V113, P242, DOI 10.1016/S0194-5998(95)70112-5 Zocratto OB, 2011, DYSPHAGIA, V26, P144, DOI 10.1007/s00455-010-9284-2 Zocratto OB, 2006, OTOLARYNG HEAD NECK, V135, P571, DOI 10.1016/j.otohns.2006.05.018 NR 17 TC 1 Z9 1 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD MAR PY 2012 VL 121 IS 3 BP 151 EP 155 PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA 911CP UT WOS:000301695200002 PM 22530473 ER PT J AU Ahmad, RARL Sivalingam, S Topsakal, V Russo, A Taibah, A Sanna, M AF Ahmad, Raja Ahmad R. Lope Sivalingam, Shailendra Topsakal, Vedat Russo, Alessandra Taibah, Abdelkader Sanna, Mario TI Rate of Recurrent Vestibular Schwannoma After Total Removal Via Different Surgical Approaches SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE middle cranial fossa approach; recurrence; retrosigmoid approach; translabyrinthine approach; vestibular schwannoma ID ACOUSTIC NEUROMA SURGERY; HEARING PRESERVATION; FACIAL-NERVE; RETROSIGMOID APPROACH; MIDDLE FOSSA; MANAGEMENT; RESECTION; EXPOSURE; FUNDUS AB Objectives: The objective of this study was to assess the differences in the recurrence rates of vestibular schwannoma (VS) after total tumor removal through enlarged translabyrinthine (ETL), retrosigmoid (RS), and middle cranial fossa (MCF) approaches. Our results were compared with previously published data, and literature reviews were done to identify the possible causes for the recurrence of VS. Methods: We performed a retrospective analysis of 2,400 cases of VS that underwent removal at the Gruppo Otologico, Piacenza, Italy, from 1983 until 2010. The minimum postoperative follow-up was 12 months. We also reviewed the previously published data on recurrence rates of VS after ETL, RS, and MCF approaches. Results: Total tumor removal was achieved in 2,252 cases (93.8%). The recurrence rate was 0.05% for the ETL approach, 0.7% for the RS approach, and 1.8% for the MCF approach. Literature reviews of 3 previously published case series utilizing the translabyrinthine approach showed that none of the primary tumors were less than 2.0 cm in size. Recurrences were seen between I and 13 years after the initial surgery. Conclusions: The rate of VS recurrence after total removal is exceptionally low in experienced hands. Undetected microscopic deposits left on crucial points such as the facial nerve, the preserved cochlea nerve, or the fundus of the internal auditory canal could be possible causes for the recurrence. A definite advantage of an ETL approach is the excellent internal auditory canal exposure, resulting in an extremely low rate of VS recurrence. The patients should be followed up to 15 years with gadolinium-enhanced magnetic resonance imaging (with fat suppression sequence in ETL approach cases). Recurrent VS may exhibit a faster growth rate than primary VS. C1 [Ahmad, Raja Ahmad R. Lope; Sivalingam, Shailendra; Topsakal, Vedat; Russo, Alessandra; Taibah, Abdelkader; Sanna, Mario] Dept Otol & Skull Base Surg, Grp Otol, Piacenza, Italy. RP Ahmad, RARL (reprint author), Int Islamic Univ Malaysia, Jalan Hosp, Dept Otolaryngol Head & Neck Surg, Kuantan 25710, Pahang, Malaysia. RI R Lope Ahmad, Raja Ahmad/E-6597-2012 FU Association Italiana Neurootologico (AINOT) FX From the Department of Otology and Skull Base Suruery, Gruppo Otologico, Piacenza, Italy. Supported by a grant from the Association Italiana Neurootologico (AINOT). CR BATTISTA RA, 1995, AM J OTOL, V16, P628 BEATTY CW, 1987, LARYNGOSCOPE, V97, P1168 Caye-Thomasen P, 2005, OTOL NEUROTOL, V26, P98 EBERSOLD MJ, 1992, J NEUROSURG, V76, P901, DOI 10.3171/jns.1992.76.6.0901 ECKERMEIER L, 1979, ARCH OHREN NASEN KEH, V222, P1, DOI 10.1007/BF00456332 El-Kashlan HK, 2000, AM J OTOL, V21, P389, DOI 10.1016/S0196-0709(00)80049-6 ELSTER AD, 1990, RADIOLOGY, V174, P93 Falcioni M, 2011, J NEUROSURG, V115, P820, DOI 10.3171/2011.5.JNS101597 Freeman SRM, 2007, OTOL NEUROTOL, V28, P1076 GAMACHE FW, 1992, ACOUSTIC NEUROMA, P705 Gjuric M, 2001, OTOL NEUROTOL, V22, P223, DOI 10.1097/00129492-200103000-00019 GLASSCOCK ME, 1986, LARYNGOSCOPE, V96, P1088 Haberkamp TJ, 1998, LARYNGOSCOPE, V108, P1190, DOI 10.1097/00005537-199808000-00017 HOUSE JW, 1985, OTOLARYNG HEAD NECK, V93, P146 JAASKELAINEN J, 1994, J NEUROSURG, V80, P541, DOI 10.3171/jns.1994.80.3.0541 KANZAKI J, 1991, ACTA OTO-LARYNGOL, P17 LUETJE CM, 1983, LARYNGOSCOPE, V93, P1133 Mazzoni A, 2000, AM J OTOL, V21, P98, DOI 10.1016/S0196-0709(00)80082-4 Mazzoni A, 1996, SKULL BASE SURG, V6, P105, DOI 10.1055/s-2008-1058651 Meyer TA, 2006, OTOL NEUROTOL, V27, P380, DOI 10.1097/00129492-200604000-00015 NEELY JG, 1981, LARYNGOSCOPE, V91, P1512 Roberson JB, 1996, AM J OTOL, V17, P307 Samii M, 1997, NEUROSURGERY, V40, P11, DOI 10.1097/00006123-199701000-00002 Sanna M, 2002, OTOL NEUROTOL, V23, P980, DOI 10.1097/00129492-200211000-00028 Sanna M, 2008, ATLAS MICROSURGERY L Sanna M, 2011, ATLAS ACOUSTIC NEURI SCHESSEL DA, 1992, AM J OTOL, V13, P233 SHELTON C, 1995, LARYNGOSCOPE, V105, P958, DOI 10.1288/00005537-199509000-00016 THEDINGER BA, 1992, LARYNGOSCOPE, V102, P261 NR 29 TC 2 Z9 4 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD MAR PY 2012 VL 121 IS 3 BP 156 EP 161 PG 6 WC Otorhinolaryngology SC Otorhinolaryngology GA 911CP UT WOS:000301695200003 PM 22530474 ER PT J AU Ikeda, R Kobayashi, T Kawase, T Oshima, T Sato, T AF Ikeda, Ryoukichi Kobayashi, Toshimitsu Kawase, Tetsuaki Oshima, Takeshi Sato, Toshinori TI Risk Factors for Deterioration of Bone Conduction Hearing in Cases of Labyrinthine Fistula Caused by Middle Ear Cholesteatoma SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE cholesteatoma; computed tomography; labyrinthine fistula; sensorineural hearing loss ID SEMICIRCULAR CANAL DESTRUCTION; TRANSLABYRINTHINE APPROACH; MANAGEMENT; SURGERY; PRESERVATION; OCCLUSION; COCHLEA AB Objectives: We evaluated the risk factors and outcomes of bone conduction (BC) hearing in cases of labyrinthine fistulas treated under the basic principle of complete removal of the cholesteatoma matrix. Methods: A total of 47 patients with labyrinthine fistulas were analyzed. The fistulas were classified into smaller (no more than 3 mm) and larger fistulas (more than 3 mm). The fistulas were classified by depth into 3 stages. Preoperative symptoms and postoperative results with special reference to BC hearing were analyzed. Results: Total preoperative loss of BC hearing was found in 3 of 36 ears (9%) in the smaller-fistula group and 4 of 11 ears (36%) in the larger-fistula group; this was a statistically significant difference. The BC hearing was preserved after operation in 30 of 31 ears (97%) in the smaller-fistula group and 5 of 7 ears (71%) in the larger-fistula group; this difference was also significant. The stage (depth) of the fistula did not correlate with the postoperative BC hearing. Conclusions: In smaller labyrinthine fistulas, complete removal of the cholesteatoma matrix can be relatively safely performed. However, in patients with larger fistulas, there is a potential for a complete loss of BC hearing. C1 [Ikeda, Ryoukichi] Tohoku Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, Aoba Ku, Sendai, Miyagi 9808574, Japan. RP Ikeda, R (reprint author), Tohoku Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, Aoba Ku, 1-1 Seiryo Machi, Sendai, Miyagi 9808574, Japan. FU Ministry of Education, Culture, Sports, Science and Technology [21390457] FX From the Department of Otolaryngology-Head and Neck Surgery, Tohoku University School of Medicine, Sendai, Japan. This study was supported by a grant from the Ministry of Education, Culture, Sports, Science and Technology, Grant-in-Aid for Scientific Research (B) 21390457. CR BATES GJEM, 1988, ACTA OTO-LARYNGOL, V106, P40, DOI 10.3109/00016488809107369 Copeland BJ, 2003, AM J OTOLARYNG, V24, P51, DOI 10.1053/ajot.2003.10 DORNHOFFER JL, 1995, OTOLARYNG HEAD NECK, V112, P410, DOI 10.1016/S0194-5998(95)70275-X Fuse T, 1996, J COMPUT ASSIST TOMO, V20, P221, DOI 10.1097/00004728-199603000-00009 Hakuba N, 2002, OTOL NEUROTOL, V23, P832, DOI 10.1097/00129492-200211000-00003 HIRSCH BE, 1993, AM J OTOL, V14, P533 Iguchi H, 1998, ACTA OTO-LARYNGOL, V118, P511, DOI 10.1080/00016489850154649 Ikeda R, 2010, NEUROREPORT, V21, P651, DOI 10.1097/WNR.0b013e32833a7d88 Ikeda R, 2010, HEARING RES, V265, P90, DOI 10.1016/j.heares.2009.12.027 Ikeda R, 2011, ACTA OTO-LARYNGOL, V131, P572, DOI 10.3109/00016489.2010.539262 KOBAYASHI T, 1995, ARCH OTOLARYNGOL, V121, P469 KOBAYASHI T, 1991, ARCH OTOLARYNGOL, V117, P1292 KOBAYASHI T, 1989, AM J OTOL, V10, P5 MCELVEEN JT, 1991, J LARYNGOL OTOL, V105, P34, DOI 10.1017/S0022215100114768 PALVA T, 1989, ARCH OTOLARYNGOL, V115, P804 PARNES LS, 1990, ANN OTO RHINOL LARYN, V99, P330 SANNA M, 1988, AM J OTOL, V9, P470 SHEEHY JL, 1979, LARYNGOSCOPE, V89, P78 Smouha EE, 1996, OTOLARYNG HEAD NECK, V114, P777, DOI 10.1016/S0194-5998(96)70101-8 SMYTH GDL, 1978, OTOLARYNG CLIN N AM, V11, P95 Sone M, 2007, OTOL NEUROTOL, V28, P1029 Yamamoto N, 2010, ACTA OTO-LARYNGOL, V563, P16 Yin S, 2008, ACTA OTO-LARYNGOL, V128, P739, DOI 10.1080/00016480701730000 NR 23 TC 4 Z9 4 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD MAR PY 2012 VL 121 IS 3 BP 162 EP 167 PG 6 WC Otorhinolaryngology SC Otorhinolaryngology GA 911CP UT WOS:000301695200004 PM 22530475 ER PT J AU Ahn, JH An, YS Bae, JS Kim, DY AF Ahn, Joong Ho An, Yun Suk Bae, Ji Sun Kim, Do Yoon TI Postoperative Results of Tympanoplasty With Mastoidectomy in Elderly Patients With Chronic Otitis Media SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE elderly; mastoiditis; otitis media; postoperative complication ID SENSORINEURAL HEARING-LOSS AB Objectives: We evaluated the long-term results of tympanoplasty with mastoidectomy in elderly patients with chronic otitis media (COM). Methods: We included 192 patients with intractable COM who underwent both tympanoplasty and mastoidectomy from the same surgeon between January 2003 and December 2006 and were followed up for more than 3 years. The patients were divided into two groups: an "old COM group" of 83 patients (more than 65 years of age) and a "young COM group" of 109 patients (between 21 and 40 years of age). We compared the preoperative and postoperative levels of hearing, the types of tympanoplasty and mastoidectomy, and the postoperative complications of the two groups. Results: Among the old COM group, 11 patients (13.3%) showed temporary postoperative complaints without serious sequelae. Between the old and young COM groups, there were no significant differences in the rates of associated cholesteatoma, middle ear swab culture results, or type of tympanoplasty, ossiculoplasty, and mastoidectomy. In the comparison of postoperative hearing improvement, both the old and young COM groups showed a significant decrease in air-bone gap, although the old COM group showed a significantly worse preoperative air-bone gap. There were no significant differences in the rates of re-perforation of the tympanic membrane or of reoperation between the two groups. Conclusions: From this study, we conclude that there is no reason to withhold surgery for COM on the assumption that older patients do not have good results or that the procedure is too risky. C1 [Ahn, Joong Ho; An, Yun Suk; Bae, Ji Sun; Kim, Do Yoon] Univ Ulsan, Coll Med, Asan Med Ctr, Dept Otolaryngol, Seoul 138736, South Korea. RP Ahn, JH (reprint author), Univ Ulsan, Coll Med, Asan Med Ctr, Dept Otolaryngol, 388-1 Pungnap 2 Dong Songpa Gu, Seoul 138736, South Korea. FU Asan Institute for Life Sciences [2007-376] FX From the Department of Otolaryngology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. This study was supported by a grant (2007-376) from the Asan Institute for Life Sciences. CR AUSTIN DF, 1971, ARCHIV OTOLARYNGOL, V94, P525 Bennett M, 2006, OTOLARYNG CLIN N AM, V39, P1095, DOI 10.1016/j.otc.2006.08.012 Blakley BW, 1998, OTOLARYNG HEAD NECK, V119, P559, DOI 10.1016/S0194-5998(98)70011-7 Eisenman DJ, 1998, AM J OTOL, V19, P20 Goycoolea MV, 1999, OTOLARYNG CLIN N AM, V32, P513, DOI 10.1016/S0030-6665(05)70149-3 Haynes D S, 2001, Ear Nose Throat J, V80, P8 LEVINE BA, 1989, ARCH OTOLARYNGOL, V115, P814 MORIZONO T, 1985, ARCH OTOLARYNGOL, V111, P794 Panda A, 2009, TRENDS IMMUNOL, V30, P325, DOI 10.1016/j.it.2009.05.004 Paparella M M, 1970, Trans Am Acad Ophthalmol Otolaryngol, V74, P108 Population Resource Center, AG AM Sakagami M, 2000, Auris Nasus Larynx, V27, P117, DOI 10.1016/S0385-8146(99)00065-6 SPANDOW O, 1990, LARYNGOSCOPE, V100, P995 Tacconelli E, 2002, EMERG INFECT DIS, V8, P220 WULLSTEIN H, 1956, Laryngoscope, V66, P1076 Xia YP, 2001, J INVEST DERMATOL, V116, P50, DOI 10.1046/j.1523-1747.2001.00209.x Yoshida H, 2009, AURIS NASUS LARYNX, V36, P269, DOI 10.1016/j.anl.2008.07.004 NR 17 TC 2 Z9 2 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD MAR PY 2012 VL 121 IS 3 BP 168 EP 173 PG 6 WC Otorhinolaryngology SC Otorhinolaryngology GA 911CP UT WOS:000301695200005 PM 22530476 ER PT J AU Kiyohara, H Umezaki, T Sawatsubashi, M Matsumoto, N Komune, S AF Kiyohara, Hideyuki Umezaki, Toshiro Sawatsubashi, Motohiro Matsumoto, Nozomu Komune, Shizuo TI Evaluation of Volitional and Reflexive Swallowing in Elderly Patients With a History of Pneumonia SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE dysphagia; endoscopic supine swallow-evoking test; pneumonia; reflexive swallowing; volitional swallowing ID ASPIRATION PNEUMONIA; DYSPHAGIA; MANAGEMENT; HUMANS; CARE AB Objectives: Precise assessment of the risk of aspiration is critical in older patients with a history of pneumonia. However, the currently popular videofluoroscopic and videoendoscopic examinations of swallowing only evaluate volitional swallowing. A method for quantitative analysis of reflexive swallowing is not yet available. Methods: We evaluated volitional swallowing in the sitting position by videoendoscopic examination and then measured the volume of injected water that triggered reflexive swallowing in the supine position in 54 patients with a history of pneumonia and 24 control patients of a similar age who had no history of pneumonia. Results: The volume of injected water that triggered reflexive swallowing was larger in the pneumonia group than in the control group (mean, 1.64 +/- 0.61 mL versus 0.71 +/- 0.28 mL; p <0.001). Both impaired volitional swallowing and impaired reflexive swallowing independently correlated with a history of pneumonia. Conclusions: The endoscopic supine swallow-evoking test ("ESSET") may detect previously omitted risk factors for aspiration in patients who can volitionally swallow. C1 [Kiyohara, Hideyuki] Kyushu Univ, Grad Sch Med Sci, Dept Otorhinolaryngol Head & Neck Surg, Higashi Ku, Fukuoka 8128582, Japan. [Kiyohara, Hideyuki] Oda Reg Med Ctr, Dept Otorhinolaryngol Head & Neck Surg, Kashima, Japan. RP Kiyohara, H (reprint author), Kyushu Univ, Grad Sch Med Sci, Dept Otorhinolaryngol Head & Neck Surg, Higashi Ku, 3-1-1 Maidashi, Fukuoka 8128582, Japan. FU Japan Society for the Promotion of Science [C 20592022] FX From the Department of Otorhinolaryngology-Head and Neck Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka (all authors), and the Department of Otorhinolaryngology-Head and Neck Surgery, Oda Regional Medical Center, Kashima (Kiyohara), Japan. This study was supported by a Grant-in-Aid for Scientific Research by the Japan Society for the Promotion of Science to Dr Umezaki (Scientific Research C 20592022). CR Aviv JE, 2000, ANN OTO RHINOL LARYN, V109, P1000 Aviv JE, 2002, LARYNGOSCOPE, V112, P338, DOI 10.1097/00005537-200202000-00025 Aviv Jonathan E., 1994, Annals of Otology Rhinology and Laryngology, V103, P749 Cabre M, 2009, CURR OPIN PULM MED, V15, P223, DOI 10.1097/MCP.0b013e328326f571 Dziewas R, 2003, NEUROIMAGE, V20, P135, DOI 10.1016/S1053-8119(03)00285-4 Ertekin C, 2011, DYSPHAGIA, V26, P183, DOI 10.1007/s00455-010-9319-8 Ertekin C, 2001, DYSPHAGIA, V16, P40, DOI 10.1007/s004550000041 Jean A, 2001, PHYSIOL REV, V81, P929 Kern MK, 2001, AM J PHYSIOL-GASTR L, V280, pG354 Kikawada M, 2005, DRUG AGING, V22, P115, DOI 10.2165/00002512-200522020-00003 Kitagawa JI, 2002, AM J PHYSIOL-REG I, V282, pR1342, DOI 10.1152/ajpregu.00556.2001 LANGMORE SE, 1991, ANN OTO RHINOL LARYN, V100, P678 Loeb MB, 2003, J AM GERIATR SOC, V51, P1018, DOI 10.1046/j.1365-2389.2003.51318.x Logemann JA, 1997, OTOLARYNG HEAD NECK, V116, P335, DOI 10.1016/S0194-5998(97)70269-9 Marik PE, 2001, NEW ENGL J MED, V344, P665, DOI 10.1056/NEJM200103013440908 Marik PE, 2003, CHEST, V124, P328, DOI 10.1378/chest.124.1.328 Mu LC, 2000, ANAT REC, V258, P406, DOI 10.1002/(SICI)1097-0185(20000401)258:4<406::AID-AR9>3.0.CO;2-5 Nakagawa T, 1997, ARCH INTERN MED, V157, P321, DOI 10.1001/archinte.157.3.321 Nishino T, 2000, JPN J PHYSIOL, V50, P3, DOI 10.2170/jjphysiol.50.3 NISHINO T, 1993, ANESTHESIOLOGY, V79, P588, DOI 10.1097/00000542-199309000-00024 Shaker R, 2003, GERONTOLOGY, V49, P12, DOI 10.1159/000066504 SHAKER R, 1994, GASTROENTEROLOGY, V107, P396 Teramoto S, 1999, LANCET, V353, P1243, DOI 10.1016/S0140-6736(98)05844-9 Teramoto S, 2008, J AM GERIATR SOC, V56, P577, DOI 10.1111/j.1532-5415.2008.01597.x Yoneyama T, 1999, LANCET, V354, P515, DOI 10.1016/S0140-6736(05)75550-1 NR 25 TC 0 Z9 0 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD MAR PY 2012 VL 121 IS 3 BP 174 EP 178 PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA 911CP UT WOS:000301695200006 PM 22530477 ER PT J AU Salomone, R Costa, HJZR Rodrigues, JRF Silva, SMRE Orando, PC Bento, RF AF Salomone, Raquel Zabeu Rossi Costa, Heloisa Juliana Ferreira Rodrigues, Jose Ricardo Reis e Silva, Samanta Marques Orando, Patricia Camacho Bento, Ricardo Ferreira TI Assessment of a Neurophysiological Model of the Mandibular Branch of the Facial Nerve in Rats by Electromyography SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE electromyography; facial nerve; nerve regeneration; neurophysiology; Wistar rat ID REGENERATION; MOTONEURONS; TRANSECTION; COMPRESSION; RECOVERY; INJURY; SUTURE; MOUSE AB Objectives: Our objective was to develop an experimental model for the noninvasive and objective evaluation of facial nerve regeneration in rats using a motor nerve conduction test (electromyography). Methods: Twenty-two rats were submitted to neurophysiological evaluation using motor nerve conduction of the mandibular branch of the facial nerve to obtain the compound muscle action potentials (CMAPs). To record the CM APs, we used two needle electrodes that were inserted into the lower lip muscle of the rat. A supramaximal electrical stimulus was applied, and the values of CMAP latency, amplitude, length, area, and stimulus intensity obtained from each side were compared by use of the Wilcoxon test. Results: There was no significant difference (all p > 0.05) in latency, amplitude, duration, area, or intensity of stimuli between the two sides. The amplitudes ranged between 1.61 and 8.30 mV, the latencies between 1.03 and 1.97 ms, and the stimulus intensities between 1.50 and 2.90 mA. Conclusions: This is a noninvasive, easy, and highly reproducible method that contributes to an improvement of the techniques previously described and may contribute to future studies of the degeneration and regeneration of the facial nerve. C1 [Salomone, Raquel; Zabeu Rossi Costa, Heloisa Juliana; Reis e Silva, Samanta Marques; Bento, Ricardo Ferreira] Univ Sao Paulo, Sch Med, Dept Otolaryngol, BR-05403000 Sao Paulo, Brazil. [Ferreira Rodrigues, Jose Ricardo] Univ Sao Paulo, Sch Med, Inst Orthoped & Trauma, BR-05403000 Sao Paulo, Brazil. [Orando, Patricia Camacho] Univ Nove Julho, Dept Biol, Sao Paulo, Brazil. RP Salomone, R (reprint author), Univ Sao Paulo, Sch Med, Dept Otolaryngol, Av Dr Eneas de Carvalho Aguiar 255,6 Andar,Sala 6, BR-05403000 Sao Paulo, Brazil. RI Yin, Ming/E-4879-2012 FU Sao Paulo Foundation FX From the Department of Otolaryngology (Salomone, Costa, Reis e Silva, Bento) and the Institute of Orthopedics and Trauma (Rodrigues), University of Sao Paulo School of Medicine, and the Department of Biology, University Nove de Julho (July 9 University; Orando), Sao Paulo, Brazil. This research was supported by the Sao Paulo Foundation for Research Support. CR BARRS DM, 1991, LARYNGOSCOPE, V101, P835 Bento RF, 1988, CONTRIBUICAO ESTUDO Borin Andrei, 2006, Braz J Otorhinolaryngol, V72, P775 BUCH VI, 1970, PLAST RECONSTR SURG, V45, P586, DOI 10.1097/00006534-197006000-00010 BUCHTHAL F, 1979, J NEUROL NEUROSUR PS, V42, P436, DOI 10.1136/jnnp.42.5.436 Byrne PJ, 2005, ARCH FACIAL PLAST S, V7, P114, DOI 10.1001/archfaci.7.2.114 CHEN S, 1993, J COMP NEUROL, V335, P576, DOI 10.1002/cne.903350409 Zabeu Rossi Costa HJ, 2007, ACTA OTO-LARYNGOL, V127, P947, DOI 10.1080/00016480601089689 DEMEDINACELI L, 1982, EXP NEUROL, V77, P634, DOI 10.1016/0014-4886(82)90234-5 Donaldson H.H., 1924, MEMOIRS WISTAR I ANA Ferreira Ricardo, 2005, Acta ortop. bras., V13, P112, DOI 10.1590/S1413-78522005000300002 Ferri CC, 1998, J NEUROBIOL, V34, P1 GANTZ BJ, 1984, ANN OTO RHINOL LARYN, V93, P394 Guntinas-Lichius O, 2005, EUR J NEUROSCI, V21, P391, DOI 10.1111/j.1460-9568.2005.03877.x Hadlock TA, 2005, ARCH FACIAL PLAST S, V7, P17, DOI 10.1001/archfaci.7.1.17 Hayashi A, 2004, PLAST RECONSTR SURG, V114, P129, DOI 10.1097/01.PRS.0000129075.96217.92 Heaton JT, 2005, MUSCLE NERVE, V31, P235, DOI 10.1002/mus.20257 LUNDBORG G, 1982, BRAIN RES, V232, P157, DOI 10.1016/0006-8993(82)90618-7 MATTOX DE, 1987, AM J OTOL, V8, P43 NATIONAL RESEARCH COUNCIL, 2003, MAN CUID US AN LAB Salomone R, 2011, OTORRINOLARINGOLOGIA, P55 Shi Y, 2009, ACTA OTO-LARYNGOL, V129, P906, DOI 10.1080/00016480802468153 Snyder-Mackler L, 2002, ELETROFISIOLOGIA CLI, P319 THOMANDER L, 1982, ACTA OTO-LARYNGOL, V93, P397, DOI 10.3109/00016488209130897 Tomov TL, 2002, EXP NEUROL, V178, P207, DOI 10.1006/exnr.2002.8040 YAMAMOTO E, 1975, ACTA OTO-LARYNGOL, V79, P390, DOI 10.3109/00016487509124702 NR 26 TC 3 Z9 4 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD MAR PY 2012 VL 121 IS 3 BP 179 EP 184 PG 6 WC Otorhinolaryngology SC Otorhinolaryngology GA 911CP UT WOS:000301695200007 PM 22530478 ER PT J AU Umeno, H Chitose, S Sato, K Ueda, Y Nakashima, T AF Umeno, Hirohito Chitose, Shun-ichi Sato, Kiminori Ueda, Yoshihisa Nakashima, Tadashi TI Long-Term Postoperative Vocal Function After Thyroplasty Type I and Fat Injection Laryngoplasty SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE autologous fat injection laryngoplasty; thyroplasty type I; vocal fold paralysis; vocal function ID AUTOLOGOUS FAT; MEDIALIZATION LARYNGOPLASTY; FOLD PARALYSIS; FRAMEWORK SURGERY AB Objectives: We evaluated the differences in the long-term functional results of medialization thyroplasty type I (MT) and autologous fat injection laryngoplasty (FIE) in patients with unilateral vocal fold paralysis. Methods: Forty-one patients underwent MT, and 73 patients underwent FIL. The voice functions before and after both surgeries were examined by aerodynamic, pitch and intensity, and acoustic analyses. The postoperative voice examinations were performed 12 months (median) after the MT, and 4 years (median) after the FIL. The differences between the preoperative and postoperative parameters were examined with a paired I-test for each group separately. For each variable, a comparison of the effects of surgery was conducted with an analysis of covariance model, with the change between the preoperative and postoperative values as the dependent variable and the preoperative value as the covariate. Results: In both groups, all parameters significantly improved after surgery. In particular, there was a significant difference for the postoperative acoustic analyses. However, the aerodynamic analysis after FIL improved more significantly in comparison to that after MT because of the respiratory handicap. Conclusions: We found that MT and FIE provided almost the same effectiveness, and that both surgeries were reliable in improving the vocal function in patients with vocal fold paralysis. C1 [Umeno, Hirohito; Chitose, Shun-ichi; Sato, Kiminori; Ueda, Yoshihisa; Nakashima, Tadashi] Kurume Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, Kurume, Fukuoka 8300011, Japan. RP Umeno, H (reprint author), Kurume Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, 67 Asahi Machi, Kurume, Fukuoka 8300011, Japan. FU Ministry of Education, Culture, Sports. Science and Technology, Japan [22591924] FX From the Department of Otolaryngology-Head and Neck Surgery, Kurume University School of Medicine, Kurume, Japan. This study was supported in part by a Grant-in Aid for Scientific Research (#22591924) from the Ministry of Education, Culture, Sports. Science and Technology, Japan. CR Hartl DM, 2009, ANN OTO RHINOL LARYN, V118, P827 Hoffman MR, 2010, LARYNGOSCOPE, V120, P769, DOI 10.1002/lary.20830 Laccourreye O, 2003, LARYNGOSCOPE, V113, P541, DOI 10.1097/00005537-200303000-00027 McCulloch TM, 1998, ANN OTO RHINOL LARYN, V107, P427 Morgan JE, 2007, LARYNGOSCOPE, V117, P2068, DOI 10.1097/MLG.0b013e318137385e Park H, 2008, LARYNGOSCOPE, V118, P1493, DOI 10.1097/MLG.0b013e3181735634 Umeno H, 2005, OTOLARYNG HEAD NECK, V132, P103, DOI 10.1016/j.otohns.2004.09.016 Umeno H, 2008, ANN OTO RHINOL LARYN, V117, P5 Umeno H, 2009, J LARYNGOL OTOL, V123, P35, DOI 10.1017/S0022215109005064 ZARETSKY LS, 1995, ANN OTO RHINOL LARYN, V104, P1 NR 10 TC 2 Z9 2 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD MAR PY 2012 VL 121 IS 3 BP 185 EP 191 PG 7 WC Otorhinolaryngology SC Otorhinolaryngology GA 911CP UT WOS:000301695200008 PM 22530479 ER PT J AU Al-Qudah, M Graham, SM AF Al-Qudah, Mohannad Graham, Scott M. TI Modified Osteoplastic Flap Approach for Frontal Sinus Disease SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE endoscopic sinus surgery; facial nerve; frontal sinus; incision; obliteration; osteoplastic flap ID FAT OBLITERATION; CORONAL APPROACH; MANAGEMENT; OPERATIONS; SURGERY AB Objectives: We review the use and outcomes of osteoplastic flap surgery in the current era of almost entirely endoscopic management of frontal sinus disease. Methods: A retrospective review was performed of 312 consecutive sinus surgeries performed for frontal sinus disease at the University of Iowa Hospitals and Clinics from July 2002 to July 2008. Results: Seventeen subjects (10 men and 7 women; mean age, 56 years) were identified. The indications for osteoplastic flap surgery were laterally located mucoceles in 8 patients, tumors in 7 patients, and osteomyelitis in 2 patients. Ten patients had skull base erosion, and 5 underwent cranialization for large posterior frontal bone defects. The average blood loss was 175 mL, and the average hospital stay was 3 days. There were no major intraoperative or perioperative complications. Two patients with mucoceles required revision surgery for disease recurrence. The mean follow-up was 25 months (range, 6 to 66 months). Conclusions: Osteoplastic flap surgery is an uncommon procedure in the modern endoscopic era of sinus surgery. In our series it was most commonly indicated for laterally located disease. Osteoplastic flap surgery is relatively safe and effective for a wide range of recalcitrant and complicated frontal sinus disorders. C1 [Al-Qudah, Mohannad] Jordan Univ Sci & Technol, Div Otolaryngol, Dept Special Surg, Irbid 22110, Jordan. [Al-Qudah, Mohannad; Graham, Scott M.] Univ Iowa, Dept Otolaryngol Head & Neck Surg, Div Rhinol, Iowa City, IA 52242 USA. RP Al-Qudah, M (reprint author), Jordan Univ Sci & Technol, Div Otolaryngol, Dept Special Surg, POB 3030, Irbid 22110, Jordan. CR Anand VK, 2005, AM J RHINOL, V19, P406 Becker SS, 2006, OTOLARYNG HEAD NECK, V135, P917, DOI 10.1016/j.otohns.2006.03.046 Correa AJ, 1999, OTOLARYNG HEAD NECK, V121, P731, DOI 10.1053/hn.1999.v121.a98218 Cypher T J, 1996, J Foot Ankle Surg, V35, P413 DONALD PJ, 1986, LARYNGOSCOPE, V96, P190 Donath A, 2006, LARYNGOSCOPE, V116, P1585, DOI 10.1097/01.mlg.0000232514.31101.39 FRODEL JL, 1993, ARCH OTOLARYNGOL, V119, P140 FRODEL JL, 1993, ARCH OTOLARYNGOL, V119, P201 GOODALE RL, 1958, ARCHIV OTOLARYNGOL, V68, P271 Hahn S, 2009, AMJ RHINOL ALLERGY, V23, P342, DOI 10.2500/ajra.2009.23.3327 HARDY JM, 1976, ANN OTO RHINOL LARYN, V85, P523 Jones NS, 2010, CUMMINGS OTOLARYNGOL, P775 Kanowitz SJ, 2008, AM J RHINOL, V22, P263, DOI 10.2500/ajr.2008.22.3164 Mendians AE, 1999, LARYNGOSCOPE, V109, P1495, DOI 10.1097/00005537-199909000-00025 Seiberling K, 2009, AMJ RHINOL ALLERGY, V23, P331, DOI 10.2500/ajra.2009.23.3321 Weber R, 2000, LARYNGOSCOPE, V110, P1037, DOI 10.1097/00005537-200006000-00028 NR 16 TC 2 Z9 2 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD MAR PY 2012 VL 121 IS 3 BP 192 EP 196 PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA 911CP UT WOS:000301695200009 PM 22530480 ER PT J AU Luo, JF Xu, L AF Luo, Jianfen Xu, Lei TI Distribution of Gentamicin in Inner Ear After Local Administration Via a Chitosan Glycerophosphate Hydrogel Delivery System SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE chitosan glycerophosphate hydrogel; cochlea; gentamicin; Meniere's disease; mouse; ototoxicity ID MENIERES-DISEASE; ROUND WINDOW; DRUG-DELIVERY; INTRATYMPANIC GENTAMICIN; HAIR-CELLS; THERAPY; MICROCATHETER; METAANALYSIS; KINETICS AB Objectives: We examined the distribution of gentamicin sulfate in the inner ear after delivery via a chitosan glycerophosphate (CGP) hydrogel system and examined the change in morphology of the hair cells so as to determine how gentamicin affected the function of the inner ear. Methods: A matrix of CGP hydrogel loaded with gentamicin conjugated with Texas Red (GTTR) was injected into the round window niche of the left ear of C57/BL6 mice. The mice were painlessly killed on day I or day 7 after injection. Confocal fluorescence microscopy was used to locate the gentamicin in the cochlear and vestibular systems. Results: In the vestibule, the intensity of GTTR staining in the hair cells of the macula of the saccule on day I was significantly stronger than that on day 7, and the number of hair cell bundles on top of the cuticular plate on day 7 was obviously decreased in comparison to that on day I. In the cochlea, the intensity of GTTR staining in the basal turn was significantly stronger than that in the medial turn on both day 1 and day 7. Negligible fluorescence was observed in the apical turn on both day I and day 7. Less-intense GTTR staining was detected on day 7 than on day 1 in both the basal turn and the medial turn. There was some outer hair cell loss in the basal turn on day 7, and no hair cell loss in the medial and apical turns at any time point. Conclusions: Gentamicin is distributed in the inner ear via the CGP hydrogel delivery system in a time-dependent and basal-to-apical manner. This finding implies that the vestibule and the basal turn may retain more gentamicin for a longer period than do other sites in the inner ear. These two characteristics may account for the high-frequency hearing loss and vestibular dysfunction seen with use of this system to deliver gentamicin into the inner ear. C1 [Luo, Jianfen] Shandong Univ, Prov Hosp, Dept Otorhinolaryngol Head & Neck Surg, Jinan 250021, Peoples R China. Shandong Prov Key Lab Otol, Jinan, Peoples R China. RP Luo, JF (reprint author), Shandong Univ, Prov Hosp, Dept Otorhinolaryngol Head & Neck Surg, 324 Jingwu Rd, Jinan 250021, Peoples R China. CR Alles MJRC, 2006, EUR ARCH OTO-RHINO-L, V263, P791, DOI 10.1007/s00405-006-0065-3 Balough BJ, 1998, OTOLARYNG HEAD NECK, V119, P427, DOI 10.1016/S0194-5998(98)70097-X BECK C, 1986, Keio Journal of Medicine, V35, P36 BECK C, 1978, ARCH OHREN NASEN KEH, V221, P149, DOI 10.1007/BF00455886 Chia SH, 2004, OTOL NEUROTOL, V25, P544, DOI 10.1097/00129492-200407000-00023 Cohen-Kerem R, 2004, LARYNGOSCOPE, V114, P2085, DOI 10.1097/01.mlg.0000149439.43478.24 Gale JE, 2002, J NEUROBIOL, V50, P81, DOI 10.1002/neu.10002 Hahn H, 2009, JARO-J ASSOC RES OTO, V32, P115 Hoffer ME, 2001, ANN NY ACAD SCI, V942, P46 Hoffer ME, 2001, LARYNGOSCOPE, V111, P1343, DOI 10.1097/00005537-200108000-00007 Imamura S, 2003, JARO, V4, P176, DOI 10.1007/s10162-002-2036-8 KEENE M, 1982, ARCH OTOLARYNGOL, V108, P65 Lii M, 2004, ACTA OTO-LARYNGOL, V552, P35 NEDZELSKI JM, 1992, J OTOLARYNGOL, V21, P95 Odkvist L M, 1989, Acta Otolaryngol Suppl, V457, P83 Paulson DP, 2008, LARYNGOSCOPE, V118, P706, DOI 10.1097/MLG.0b013e31815f8e41 Plontke SK, 2007, LARYNGOSCOPE, V117, P1191, DOI 10.1097/MLG.0b013e318058a06b Plontke SK, 2006, OTOL NEUROTOL, V27, P912, DOI 10.1097/01.mao.0000235310.72442.4e ROBERTSON D, 1989, DEV BRAIN RES, V47, P197, DOI 10.1016/0165-3806(89)90176-4 Ruel-Gariepy E, 2000, INT J PHARM, V203, P89, DOI 10.1016/S0378-5173(00)00428-2 Salt AN, 2009, AUDIOL NEURO-OTOL, V14, P350, DOI 10.1159/000241892 Sandoval R, 1998, J AM SOC NEPHROL, V9, P167 SCHUKNECHT H F, 1957, Acta Otolaryngol Suppl, V132, P1 Silverstein H, 1999, Ear Nose Throat J, V78, P595 Steyger PS, 2003, JARO-J ASSOC RES OTO, V4, P565, DOI 10.1007/s10162-003-4002-5 Stover T, 1999, HEARING RES, V136, P124, DOI 10.1016/S0378-5955(99)00115-X Wagner N, 2005, ACTA OTO-LARYNGOL, V125, P340, DOI 10.1080/00016480510026881 Wanamaker HH, 1998, AM J OTOL, V19, P170 Wang Q, 2009, JARO-J ASSOC RES OTO, V10, P205, DOI 10.1007/s10162-009-0160-4 Xu L, 2010, OTOL NEUROTOL, V31, P1115, DOI 10.1097/MAO.0b013e3181eb32d1 NR 30 TC 1 Z9 2 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD MAR PY 2012 VL 121 IS 3 BP 208 EP 216 PG 9 WC Otorhinolaryngology SC Otorhinolaryngology GA 911CP UT WOS:000301695200011 PM 22530482 ER PT J AU O'Brien, LCG Valim, C Neault, M Kammerer, B Clark, T Johnston, J Culver, S Zhou, J Kenna, MA Licameli, GR AF O'Brien, Lynne C. Graham Valim, Clarissa Neault, Marilyn Kammerer, Betsy Clark, Terrell Johnston, Jennifer Culver, Stacey Zhou, Jing Kenna, Margaret A. Licameli, Greg R. TI Prognosis Tool Based on a Modified Children's Implant Profile for Use in Pediatric Cochlear Implant Candidacy Evaluation SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE cochlear implantation; sensorineural hearing loss ID PRELINGUALLY DEAF-CHILDREN; SPEECH-PERCEPTION; PERFORMANCE; OUTCOMES; SCALE; NCHIP AB Objectives: We developed a prediction tool to assist in evaluation of pediatric candidates for cochlear implantation (CI) and to help plan for preoperative and postoperative support. Methods: Between 1995 and 2005,277 patients underwent CI at Children's Hospital Boston. Of these 277 patients, 250 had at least 2 years of post-CI follow-up and adequate pre-CI information for rating by our prediction tool. Of the 250, 106 were randomly selected for inclusion. The patients were divided into group A (auditory/oral communicator); group B (auditory/oral communicator with visual assistance), group C (visual/manual communicator with auditory/oral skills assistance), and group D (will not derive communicative benefit from implant). Predictions were performed with clinical assessment and two statistical techniques: regression modeling and classification and regression tree (CART) analysis. Results: Among patients who became auditory/oral communicators (group A), clinical assessment predicted that outcome accurately 65% of the time, CART analysis had intermediate sensitivity (79%), and regression modeling was the most sensitive (95%). Groups B through D were predicted 45% of the time by regression modeling, 90% of the time by clinical assessment, and 100% of the time by CART analysis. Conclusions: A combination of speech-language, medical, and educational constructs can provide a reliable prediction of the communication outcome. Our goal for the prognosis tool is to make it part of the overall candidacy process in supporting decision-making about CI and planning for post-CI therapy. C1 [O'Brien, Lynne C. Graham; Neault, Marilyn; Kammerer, Betsy; Clark, Terrell; Johnston, Jennifer; Culver, Stacey; Kenna, Margaret A.; Licameli, Greg R.] Childrens Hosp Boston, Dept Otolaryngol & Commun Enhancement, Boston, MA 02115 USA. [Valim, Clarissa; Zhou, Jing] Childrens Hosp Boston, Clin Res Program, Boston, MA 02115 USA. [Valim, Clarissa] Harvard Univ, Sch Med, Dept Surg, Boston, MA 02115 USA. [Neault, Marilyn; Kenna, Margaret A.; Licameli, Greg R.] Harvard Univ, Sch Med, Dept Otol & Laryngol, Boston, MA 02115 USA. [Kammerer, Betsy; Clark, Terrell] Harvard Univ, Sch Med, Dept Psychiat, Boston, MA 02115 USA. RP Licameli, GR (reprint author), Childrens Hosp Boston, Dept Otolaryngol & Commun Enhancement, 300 Longwood Ave,LO-367, Boston, MA 02115 USA. CR Allen C, 2001, OTOL NEUROTOL, V22, P631, DOI 10.1097/00129492-200109000-00012 Arnoldner C, 2004, INT J PEDIATR OTORHI, V68, P457, DOI 10.1016/j.ijporl.2003.11.018 Cohen NL, 2004, AUDIOL NEURO-OTOL, V9, P197, DOI 10.1159/000078389 Copeland BJ, 2004, ANNU REV MED, V55, P157, DOI 10.1146/annurev.med.55.091902.105251 Daya H, 1999, INT J PEDIATR OTORHI, V49, P135, DOI 10.1016/S0165-5876(99)00112-3 Dolan-Ash S, 1998, 7 S COCHL IMPL CHILD, P36 Edwards LC, 2006, INT J PEDIATR OTORHI, V70, P1593, DOI 10.1016/j.ijporl.2006.04.008 Edwards LC, 2003, INT J AUDIOL, V42, P426, DOI 10.3109/14992020309080052 FILIPO R, 2004, ACTA OTO-LARYNGOL, V552, P74 Hassanzadeh S, 2002, OTOLARYNG HEAD NECK, V126, P524, DOI 10.1067/mhn.2002.125110 HELLMAN SA, 1991, AM ANN DEAF, V136, P77 Horn DL, 2005, LARYNGOSCOPE, V115, P1603, DOI 10.1097/01.mlg.0000171018.97692.c0 Kiefer J, 2000, ADV OTO-RHINO-LARYNG, V57, P202 Lazaridis E, 2010, INT J PEDIATR OTORHI, V74, P412, DOI 10.1016/j.ijporl.2010.01.022 Lenarz Thomas, 1998, Acta Oto-Rhino-Laryngologica Belgica, V52, P183 Li YL, 2004, INT J PEDIATR OTORHI, V68, P1027, DOI 10.1016/j.ijporl.2004.03.010 Lin FR, 2007, EAR HEARING, V28, P703, DOI 10.1097/AUD.0b013e31812f71f4 MIYAMOTO RT, 1994, LARYNGOSCOPE, V104, P1120 Nikolopoulos TP, 2004, INT J PEDIATR OTORHI, V68, P127, DOI 10.1016/j.ijporl.2003.09.019 Nikolopoulos TP, 2004, ARCH OTOLARYNGOL, V130, P629, DOI 10.1001/archotol.130.5.629 Nikolopoulos TP, 2004, INT J PEDIATR OTORHI, V68, P137, DOI 10.1016/j.ijporl.2003.09.020 Pyman B, 2000, AM J OTOL, V21, P57, DOI 10.1016/S0196-0709(00)80113-1 QUARANTA N, 2004, ACTA OTO-LARYNGOL, V552, P68 Rice CE, 2005, VOLTA VOICES JUL Stern RE, 2005, LARYNGOSCOPE, V115, P125, DOI 10.1097/01.mlg.0000150698.61624.3c US Food and Drug Administration (FDA), 2010, MED DEV PREM APPR PM Valente M, 1999, TRENDS AMPLIFICATION, V4, P142 Waltzman SB, 2000, AM J OTOL, V21, P329, DOI 10.1016/S0196-0709(00)80040-X Wiley S, 2006, INT J PEDIATR OTORHI, V70, P493, DOI 10.1016/j.ijporl.2005.07.026 NR 29 TC 0 Z9 0 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD FEB PY 2012 VL 121 IS 2 BP 73 EP 84 PG 12 WC Otorhinolaryngology SC Otorhinolaryngology GA 894ZB UT WOS:000300464900001 PM 22397214 ER PT J AU Mora, R Mora, E Salzano, FA Guastini, L AF Mora, Renzo Mora, Enzo Salzano, Francesco Antonio Guastini, Luca TI Audiometric Characteristics in Patients With Noise-Induced Hearing Loss After Sodium Enoxaparin Treatment SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE noise-induced hearing loss; sodium enoxaparin ID MOLECULAR-WEIGHT HEPARIN; INFLAMMATION; STROKE AB Objectives: The aim of this study was to evaluate the effect of sodium enoxaparin treatment on patients with noise-induced hearing loss. Methods: Sixty patients with noise-induced hearing loss were included and randomly divided into two numerically equal groups. Group A underwent therapy with sodium enoxaparin for 10 days, followed by an additional 10 days of treatment after 10 days of no treatment. Group B received placebo as a control. Before treatment, at the end of treatment, and 2 months after the end of treatment, all patients underwent evaluation by laboratory tests, pure tone audiometry, transient evoked otoacoustic emissions (TEOAEs) testing, distortion product otoacoustic emissions (DPOAEs) testing, and auditory brain stem response testing. Results: In contrast to group B, at the end of the treatment in group A pure tone audiometry showed a significant (p < 0.05) improvement of the audiometric thresholds at 0.5, 1, 2, 4, and 8 kHz. Depending on the air and bone conduction thresholds, TEOAEs and DPOAES, which had previously been absent, were evoked at the frequencies examined. These improvements were confirmed at last follow-up. We found no significant differences in auditory brain stem responses or laboratory results. Conclusions: These preliminary data encourage further studies to collect additional evidence on the effect of sodium enoxaparin in preventing the development of noise-induced hearing loss. C1 [Mora, Renzo; Mora, Enzo; Guastini, Luca] Univ Genoa, Dept Otorhinolaryngol, Genoa, Italy. [Salzano, Francesco Antonio] Univ Palermo, Dept Otorhinolaryngol, Palermo, Salzano, Italy. RP Mora, R (reprint author), Via Mille 11-9, I-16147 Genoa, Italy. CR Bergamaschini L, 2004, J NEUROSCI, V24, P4181, DOI 10.1523/JNEUROSCI.0550-04.2004 Cirino G, 1997, J CLIN INVEST, V99, P2446, DOI 10.1172/JCI119428 CLARK WW, 1992, J ACOUST SOC AM, V91, P3064, DOI 10.1121/1.402943 Coordes A, 2011, J NEUROTRAUMA 1004 Dirnagl U, 1999, TRENDS NEUROSCI, V22, P391, DOI 10.1016/S0166-2236(99)01401-0 Ferreiro E, 2004, J NEUROSCI RES, V76, P872, DOI 10.1002/jnr.20135 Fetoni AR, 2011, ACTA OTO-LARYNGOL, V131, P419, DOI 10.3109/00016489.2010.539263 Franklin RD, 2003, OBSTET GYNECOL, V101, P455, DOI 10.1016/S0029-7844(02)02520-6 Hao LN, 2011, BRAIN RES, V1368, P1, DOI 10.1016/j.brainres.2010.10.064 Hawkins JE, 2005, AUDIOL NEURO-OTOL, V10, P305, DOI 10.1159/000087347 Henderson D, 2006, EAR HEARING, V27, P1, DOI 10.1097/01.aud.0000191942.36672.f3 Hong BN, 2011, NEUROSCI LETT, V487, P217, DOI 10.1016/j.neulet.2010.10.026 Le Prell CG, 2007, FREE RADICAL BIO MED, V42, P1454, DOI 10.1016/j.freeradbiomed.2007.02.008 Mary V, 2001, STROKE, V32, P993 Mora Renzo, 2005, Int Tinnitus J, V11, P38 Mora R, 2004, ACTA OTO-LARYNGOL, V552, P25 Mulders WHAM, 2009, NEUROSCIENCE, V164, P733, DOI 10.1016/j.neuroscience.2009.08.036 Ohinata Y, 2000, BRAIN RES, V878, P163, DOI 10.1016/S0006-8993(00)02733-5 Rahman A, 2009, MED SCI MONITOR, V15, pCR588 Rocha Rita Leniza Oliveira da, 2010, Braz J Otorhinolaryngol, V76, P687 Sambandan S, 2010, J NEUROSCI, V30, P11826, DOI 10.1523/JNEUROSCI.2012-10.2010 Sanchez PC, 1996, SURG NEUROL, V46, P152, DOI 10.1016/0090-3019(96)00086-9 Seidman MD, 2010, INT J ENV RES PUB HE, V7, P3730, DOI 10.3390/ijerph7103730 SLEPECKY N, 1986, HEARING RES, V22, P307, DOI 10.1016/0378-5955(86)90107-3 Spinnewyn B, 1999, J CEREBR BLOOD F MET, V19, P139 Tyrrell DJ, 1999, ADV PHARMACOL, V46, P151, DOI 10.1016/S1054-3589(08)60471-8 Yamashita D, 2004, BRAIN RES, V1019, P201, DOI 10.1016/j.brainres.2004.05.104 NR 27 TC 0 Z9 0 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD FEB PY 2012 VL 121 IS 2 BP 85 EP 90 PG 6 WC Otorhinolaryngology SC Otorhinolaryngology GA 894ZB UT WOS:000300464900002 PM 22397215 ER PT J AU Suh, JD Ramakrishnan, VR DeConde, AS AF Suh, Jeffrey D. Ramakrishnan, Vijay R. DeConde, Adam S. TI Nasal Floor Free Mucosal Graft for Skull Base Reconstruction and Cerebrospinal Fluid Leak Repair SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE cerebrospinal fluid rhinorrhea; duraplasty; free mucosal graft ID TRANSNASAL ENDOSCOPIC REPAIR; RHINORRHEA; FLAP; SURGERY AB Objectives: Donor sites for free mucosal grafts for endoscopic endonasal reconstruction of the skull base have traditionally included the middle turbinate, the inferior turbinate, and the nasal septum. The aim of this study was to demonstrate a free mucoperiosteal graft from the nasal cavity floor as a simple alternative donor site for mucosal grafts. Methods: In a cadaver study with clinical correlation, we performed endoscopic endonasal harvest of the nasal floor free mucosal graft on two sides of a cadaveric nasal cavity. We also describe the cases of two patients in whom a nasal floor free mucosal graft was used to repair a skull base defect. Results: The harvest of a nasal floor free mucosal graft is a quick, potentially less morbid method of obtaining free mucosal grafts. In the cases examined, use of this graft carried minimal morbidity and allowed for successful reconstruction of a skull base defect. Conclusions: Harvest of nasal floor mucosa is a technically simple method of obtaining free mucoperiosteum for reconstruction of the skull base. C1 [Suh, Jeffrey D.; DeConde, Adam S.] Univ Calif Los Angeles, Div Head & Neck Surg, Los Angeles, CA 90024 USA. [Ramakrishnan, Vijay R.] Univ Colorado, Dept Otolaryngol Head & Neck Surg, Aurora, CO USA. RP Suh, JD (reprint author), 200 UCLA Med Plaza,Suite 550, Los Angeles, CA 90095 USA. CR Banks CA, 2009, OTOLARYNG HEAD NECK, V140, P826, DOI [10.1016/j.otohns.2008.12.060, 10.1016/j.otohns.2009.12.060] Casiano RR, 1999, OTOLARYNG HEAD NECK, V121, P745, DOI 10.1053/hn.1999.v121.a98754 de Almeida JR, 2011, HEAD NECK-J SCI SPEC, V33, P547, DOI 10.1002/hed.21483 El-Banhawy OA, 2008, SKULL BASE-INTERD AP, V18, P297, DOI 10.1055/s-0028-1086055 Harvey RJ, 2008, AM J RHINOL, V22, P516, DOI 10.2500/ajr.2008.22.3223 Harvey RJ, 2009, J NEUROSURG, V111, P371, DOI 10.3171/2008.8.JNS08236 Hegazy HM, 2000, LARYNGOSCOPE, V110, P1166, DOI 10.1097/00005537-200007000-00019 Kassam AB, 2008, NEUROSURGERY, V63, P44, DOI 10.1227/01.NEU.0000297074.13423.F5 Lanza DC, 1996, LARYNGOSCOPE, V106, P1119, DOI 10.1097/00005537-199609000-00015 Lee HY, 2002, LARYNGOSCOPE, V112, P1813, DOI 10.1097/00005537-200210000-00020 Lee TJ, 2004, LARYNGOSCOPE, V114, P1475, DOI 10.1097/00005537-200408000-00029 Lorenz RR, 2003, LARYNGOSCOPE, V113, P496, DOI 10.1097/00005537-200303000-00019 Mahendran S, 2006, CLIN OTOLARYNGOL, V31, P324, DOI 10.1111/j.1749-4486.2006.01170.x Martin Timothy J, 2007, Curr Opin Otolaryngol Head Neck Surg, V15, P35, DOI 10.1097/MOO.0b013e3280123fce MATTOX DE, 1990, LARYNGOSCOPE, V100, P857 Prevedello DM, 2009, LARYNGOSCOPE, V119, P2094, DOI 10.1002/lary.20226 Schlosser RJ, 2004, LARYNGOSCOPE, V114, P255, DOI 10.1097/00005537-200402000-00015 Teymoortash A, 2009, J PLAST RECONSTR AES, V62, P1261, DOI 10.1016/j.bjps.2008.04.061 Teymoortash A, 2011, AM J RHINOL ALLERGY, V25, P193, DOI 10.2500/ajra.2011.25.3603 White DR, 2003, AM J OTOLARYNG, V24, P213, DOI 10.1016/S0196-0770(03)00031-0 WIGAND M E, 1981, Rhinology (Utrecht), V19, P7 Zweig JL, 2000, OTOLARYNG HEAD NECK, V123, P195, DOI 10.1067/mhm.2000.107452 NR 22 TC 3 Z9 3 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD FEB PY 2012 VL 121 IS 2 BP 91 EP 95 PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA 894ZB UT WOS:000300464900003 PM 22397216 ER PT J AU Song, JE Sapthavee, A Cager, GR Saadia-Redleaf, MI AF Song, James E. Sapthavee, Andrew Cager, Gabrielle R. Saadia-Redleaf, Miriam I. TI Pseudo-Sudden Deafness SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE sudden deafness; sudden sensorineural hearing loss ID SENSORINEURAL HEARING-LOSS; CHRONIC OTITIS-MEDIA; ROUND WINDOW MEMBRANE AB Objectives: We describe the symptom complex and management of a clinical entity we refer to as "pseudo-sudden deafness," which is an episode of acute otitis media that leads to sensorineural hearing loss with reduced speech discrimination. Methods: We included 8 adult patients with audiometrically confirmed, asymmetric sensorineural hearing loss with decreased speech discrimination that presented after an episode of acute otitis media. Magnetic resonance imaging ruled out retrocochlear disease. Both physical examination and myringotomy helped confirm the diagnosis of serous otitis media (SUM). Myringotomy, tympanostomy tubes, oral antibiotics, and otic antibiotic-steroid drops were used to treat the SOM. Oral steroids were used to treat the sensorineural component. Results: Pretreatment and posttreatment audiograms showed an improvement in speech discrimination score, pure tone thresholds, or both after treatment for underlying SUM and sensorineural hearing loss in 6 of the 8 patients. Conclusions: Patients who present with an acute onset of unilateral sensorineural hearing loss with decreased speech discrimination may be mistakenly thought to have idiopathic sudden sensorineural hearing loss when, in fact, they may have an SOM-induced phenomenon that is potentially reversible. The distinguishing feature is a preexisting otitis media, which must be treated first, before the administration of steroids. C1 [Song, James E.; Sapthavee, Andrew; Cager, Gabrielle R.; Saadia-Redleaf, Miriam I.] Univ Illinois, Eye & Ear Infirm, Chicago, IL 60612 USA. RP Saadia-Redleaf, MI (reprint author), Illinois Eye & Ear Infirm, 1855 W Taylor St, Chicago, IL 60612 USA. CR Cureoglu S, 2004, LARYNGOSCOPE, V114, P622, DOI 10.1097/00005537-200404000-00006 da Costa SS, 2009, EUR ARCH OTO-RHINO-L, V266, P221, DOI 10.1007/s00405-008-0739-0 ENGEL F, 1995, INFECT IMMUN, V63, P1305 Joglekar S, 2010, ACTA OTO-LARYNGOL, V130, P472, DOI 10.3109/00016480903311252 MacAndie C, 1999, CLIN OTOLARYNGOL, V24, P220, DOI 10.1046/j.1365-2273.1999.00237.x SAHNI RS, 1987, ARCH OTOLARYNGOL, V113, P630 NR 6 TC 1 Z9 1 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD FEB PY 2012 VL 121 IS 2 BP 96 EP 99 PG 4 WC Otorhinolaryngology SC Otorhinolaryngology GA 894ZB UT WOS:000300464900004 PM 22397217 ER PT J AU Maddox, PT Paydarfar, JA Davies, L AF Maddox, Patrick Tate Paydarfar, Joseph Ali Davies, Louise TI Parotidectomy: A 17-Year Institutional Experience at a Rural Academic Medical Center SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE head and neck surgery; parotidectomy; salivary gland ID TUMORS; OUTCOMES; SURGERY; DISEASE; GLAND AB Objectives: We describe the parotidectomy experience at a single rural institution over 17 years. Methods: We retrieved the records of all patients who underwent parotidectomy for any nontrauma indication (current procedural terminology codes 42410, 42415, 42420, 42425, and 42426) from January 1990 to June 2007 at Dartmouth-Hitchcock Medical Center, a rural medical center that provides both primary and tertiary care to a local population of 14,000, with a catchment area of 600,000 people. Information was collected on initial patient presentation, use of fine-needle aspiration, extent of surgery, final pathologic diagnosis, and complications. Results: We performed 341 parotidectomy procedures in 334 patients. The largest number of malignancies came from metastatic tumors; squamous cell carcinoma was the most common (37% of malignancies). The most common presenting complaint overall was a painless mass. The most common complication was facial weakness in 17% (57 of 341); 36 of the 57 cases of facial weakness (63%) were associated with surgery for malignancy. The most common benign tumor was pleomorphic adenoma (114 of 186; 61%). Mucoepidermoid carcinoma was the most common primary parotid malignancy (12%). Conclusions: In this 17-year rural case series of all parotidectomy procedures done for nontrauma indications, the largest number of malignancies came from metastatic tumors. Although facial nerve paralysis is not a common complication, it occurs most often when surgery is performed for either primary or metastatic malignancy. Surgeons will benefit from this information as they counsel patients who are considering parotidectomy. C1 [Maddox, Patrick Tate; Paydarfar, Joseph Ali; Davies, Louise] Dartmouth Coll, Hitchcock Med Ctr, Dartmouth Med Sch, Div Otolaryngol Head & Neck Surg,Dept Surg, Hanover, NH 03756 USA. [Davies, Louise] Dartmouth Inst Hlth Policy & Clin Practice, Hanover, NH USA. [Davies, Louise] Dept Vet Affairs Med Ctr, Outcomes Grp, White River Jct, VT USA. RP Paydarfar, JA (reprint author), 1 Med Ctr Dr, Lebanon, NH 03756 USA. CR Ali NS, 2010, ASIAN PAC J CANCER P, V11, P1111 Al Salamah SM, 2005, ANZ J SURG, V75, P948, DOI 10.1111/j.1445-2197.2005.03580.x Bova R, 2004, ANZ J SURG, V74, P563, DOI 10.1111/j.1445-2197.2004.02988.x Bron LP, 1997, ARCH OTOLARYNGOL, V123, P1091 Burgess AN, 2008, ANZ J SURG, V78, P791, DOI 10.1111/j.1445-2197.2008.04651.x Eng CY, 2007, J LARYNGOL OTOL, V121, P40, DOI 10.1017/S0022215106002702 Guntinas-Lichius O, 2006, LARYNGOSCOPE, V116, P534, DOI 10.1097/01.mlg.0000200741.37460.ea HUGO NE, 1973, SURG CLIN N AM, V53, P105 Koch M, 2010, LARYNGOSCOPE, V120, P724, DOI 10.1002/lary.20822 Lin CC, 2008, AM J OTOLARYNG, V29, P94, DOI 10.1016/j.amjoto.2007.03.002 SPIRO RH, 1986, HEAD NECK-J SCI SPEC, V8, P177, DOI 10.1002/hed.2890080309 Takahama Junior Ademar, 2009, Braz J Otorhinolaryngol, V75, P497, DOI 10.1590/S1808-86942009000400005 Upton DC, 2007, OTOLARYNG HEAD NECK, V136, P788, DOI 10.1016/j.otohns.2006.11.037 NR 13 TC 5 Z9 5 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD FEB PY 2012 VL 121 IS 2 BP 100 EP 103 PG 4 WC Otorhinolaryngology SC Otorhinolaryngology GA 894ZB UT WOS:000300464900005 PM 22397218 ER PT J AU Gallo, A Pagliuca, G de Vincentiis, M Martellucci, S Iallonardi, E Fanello, G Cereatti, F Fiocca, F AF Gallo, Andrea Pagliuca, Giulio de Vincentiis, Marco Martellucci, Salvatore Iallonardi, Elsa Fanello, Gianfranco Cereatti, Fabrizio Fiocca, Fausto TI Endoscopic Treatment of Benign and Malignant Strictures of the Cervical Esophagus and Hypopharynx SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article; Proceedings Paper CT Meeting of the American-Broncho-Esophagological-Association CY APR 27-28, 2011 CL Chicago, IL SP Amer Broncho Esophagol Assoc DE cervical esophageal stricture; dysphagia; endoscopic dilation; hypopharyngeal stricture; self-expandable stent ID STENT PLACEMENT; MANAGEMENT; COMPLICATIONS AB Objectives: We evaluated the efficacy of endoscopic techniques employed in the management of cervical esophageal and hypopharyngeal strictures. Methods: A series of 45 patients with cervical esophageal (35) and/or hypopharyngeal strictures (10) were included. Twenty-five patients (55.6%) with neoplastic strictures were treated for palliation alone. The stenosis was related to radiotherapy in 11 patients (24.4%) and to postsurgical complications in 9 (20%). A group of 23 patients was treated with dilation alone (group I). A second group included 22 patients treated with insertion of a self-expandable stent after failure of dilation treatment (group 2). The swallowing test data, clinical notes, and surgical reports were reviewed. Results: All of the patients showed some degree of relief of dysphagia. In group 1, 19 of the 23 patients required multiple dilation treatments to maintain normal deglutition. In group 2, 7 of the 22 patients recovered regular oral feeding after stent placement, 10 patients reported pain and foreign body sensation, 2 patients reported pain so severe that stent removal was required, and 3 patients experienced stent migration. All but 3 of the 25 patients with inoperable tumors died during follow-up, but no patients with benign stenosis died. Conclusions: The two groups showed comparable functional results. Dilation often requires multiple procedures, but is usually well tolerated. Placement of self-expandable stents is effective, but is generally less well tolerated. C1 [Gallo, Andrea; Pagliuca, Giulio; Martellucci, Salvatore] Univ Roma La Sapienza, Dept Med Surg Sci & Biotechnol, Rome, Italy. [de Vincentiis, Marco; Iallonardi, Elsa] Univ Roma La Sapienza, Dept Sensorial Organs, Otorhinolaryngol Sect, Rome, Italy. [Fanello, Gianfranco; Cereatti, Fabrizio; Fiocca, Fausto] Univ Roma La Sapienza, Dept Surg Paride Stefanini, Rome, Italy. RP Gallo, A (reprint author), Via Adolfo Venturi 19, I-00162 Rome, Italy. CR Ahlawat SK, 2008, GASTROINTEST ENDOSC, V68, P19, DOI 10.1016/j.gie.2007.11.027 Conio M, 2007, GASTROINTEST ENDOSC, V65, P714, DOI 10.1016/j.gie.2007.02.050 Costamagna G, 2006, EUR J GASTROEN HEPAT, V18, P1177 Ferguson DD, 2005, DIS ESOPHAGUS, V18, P359, DOI 10.1111/j.1442-2050.2005.00516.x Gislason GT, 1997, DYSPHAGIA, V12, P84 Hernandez LV, 2003, GASTROINTEST ENDOSC, V58, P642 Kochman ML, 2005, GASTROINTEST ENDOSC, V62, P474, DOI 10.1016/j.gie.2005.04.050 Lee SH, 2001, BRIT J RADIOL, V74, P891 Lee WT, 2006, HEAD NECK-J SCI SPEC, V28, P808, DOI 10.1002/hed.20427 MELLOW MH, 1985, ARCH INTERN MED, V145, P1443, DOI 10.1001/archinte.145.8.1443 Piotet E, 2008, EUR ARCH OTO-RHINO-L, V265, P357, DOI 10.1007/s00405-007-0456-0 Profili S, 2002, CLIN RADIOL, V57, P1028, DOI 10.1053/crad.2002.0988 Somani SK, 2010, GASTROINTEST ENDOSC, V71, P1304, DOI 10.1016/j.gie.2009.12.050 Triboulet JP, 2001, ARCH SURG-CHICAGO, V136, P1164, DOI 10.1001/archsurg.136.10.1164 Turkyilmaz A, 2010, SURG LAPARO ENDO PER, V20, P10, DOI 10.1097/SLE.0b013e3181cdebf4 Verschuur EML, 2007, GASTROINTEST ENDOSC, V66, P1082, DOI 10.1016/j.gie.2007.03.1087 Wang MQ, 2001, J VASC INTERV RADIOL, V12, P465, DOI 10.1016/S1051-0443(07)61886-7 NR 17 TC 1 Z9 1 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD FEB PY 2012 VL 121 IS 2 BP 104 EP 109 PG 6 WC Otorhinolaryngology SC Otorhinolaryngology GA 894ZB UT WOS:000300464900006 PM 22397219 ER PT J AU Konishi, M Sivalingam, S Shin, SH Vitullo, F Falcioni, M AF Konishi, Masaya Sivalingam, Shailendra Shin, Seung-Ho Vitullo, Francesca Falcioni, Maurizio TI Effects of Early Commercial Air Travel on Graft Healing Rates After Tympanoplasty SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE early air travel; graft healing rate; tympanoplasty ID MYRINGOPLASTY; CHILDREN AB Objectives: We sought to determine whether commercial air travel soon after tympanoplasty significantly affects graft healing rates. Methods: We performed a retrospective analysis of 169 patients who underwent tympanoplasty from 1993 to 2009, comparing two groups of patients: 69 patients who flew I day after surgery and 100 who did not. The confounding factors analyzed were side of surgery, size of perforation, surgical approach, graft material, and grafting technique. The primary outcome measure analyzed was successful closure of the perforation at the first follow-up visit, at 4 weeks, evidenced by direct otoendoscopic examination. Results: There was no significant difference in the confounding variables between the two groups. There was no significant difference in the primary outcome measure of graft healing rates between the two groups (p = 0.494). Additionally, the overall graft healing rates compared favorably with previously published data from other authors. Conclusions: Early commercial air travel after tympanoplasty does not significantly affect graft healing rates and should be considered a relatively safe option. C1 [Konishi, Masaya; Sivalingam, Shailendra; Shin, Seung-Ho; Vitullo, Francesca; Falcioni, Maurizio] Grp Otol, Piacenza, Italy. RP Shin, SH (reprint author), CHA Univ, CHA Bundang Med Ctr, Dept Otolaryngol Head & Neck Surg, 351 Yatap Dong, Songnam, Gyeonggi Do, South Korea. FU Associazione Italiana Neurootologica FX Supported by a grant from the Associazione Italiana Neurootologica. CR Fayad JN, 2010, OTOLOGIC SURG, P119, DOI 10.1016/B978-1-4160-4665-3.00009-3 Jassar P, 2002, CLIN OTOLARYNGOL, V27, P48, DOI 10.1046/j.0307-7772.2001.00522.x KOCH WM, 1990, ARCH OTOLARYNGOL, V116, P35 Mirza S, 2005, J LARYNGOL OTOL, V119, P366 Rizer FM, 1997, LARYNGOSCOPE, V107, P26, DOI 10.1097/00005537-199712001-00002 SHIH L, 1991, OTOLARYNG HEAD NECK, V105, P74 Telian SA, 2003, BALLENGERS OTORHINOL, P261 NR 7 TC 0 Z9 0 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD FEB PY 2012 VL 121 IS 2 BP 110 EP 112 PG 3 WC Otorhinolaryngology SC Otorhinolaryngology GA 894ZB UT WOS:000300464900007 PM 22397220 ER PT J AU Hirai, R Takao, K Onoda, K Kokubun, S Ikeda, M AF Hirai, Ryoji Takao, Kyoichi Onoda, Keiko Kokubun, Shinichiro Ikeda, Minoru TI Patients With Phantogeusia Show Increased Expression of T2R Taste Receptor Genes in Their Tongues SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE bitterness; phantogeusia; T2R; TAS2R; taste disorder; taste receptor gene ID CHORDA TYMPANI NERVE; BITTER TASTE; ACESULFAME-K; SWEET TASTE; DISORDERS; SACCHARIN; SURGERY; SYMPTOM; FAMILY AB Objectives: The taste receptor gene family T2R has been implicated in the sensation of bitter taste. Phantogeusia is a spontaneous abnormal taste with no external stimulus. We analyzed the expression of T2R taste receptor genes in the tongues of patients with phantogeusia to assess their role in the pathogenesis of phantogeusia. Methods: We obtained specimens from 43 patients with phantogeusia and 24 normal volunteers by scraping the foliate papillae and examined these specimens for the expression of 10 T2R taste receptor genes using reverse transcription polymerase chain reaction and electrophoresis. Results: The expression rate (subjects with detectable expression) of the 10 taste receptor genes in the healthy subjects ranged from 16.7% to 100%; 3 receptor genes were found in 50% or fewer of these subjects. In the patients with phantogeusia, the expression rate was increased significantly compared to that in the healthy control subjects for 3 of the 10 receptor genes examined. Conclusions: Our results show that the expression rate of some of the T2R taste receptor genes was increased significantly in patients with phantogeusia. These results suggest that increased expression of taste receptor genes is involved in the pathogenesis of phantogeusia; this finding may contribute to elucidation of the mechanism of this disorder. C1 [Hirai, Ryoji] Nihon Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, Itabashi Ku, Tokyo 1738610, Japan. [Takao, Kyoichi; Kokubun, Shinichiro] Nihon Univ, Sch Med, Dept Physiol, Tokyo 1738610, Japan. RP Hirai, R (reprint author), Nihon Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, Itabashi Ku, 30-1 Oyaguchi Kamicho, Tokyo 1738610, Japan. FU Ministry of Education, Science, Culture, and Sports in Japan [22591922] FX This study was supported by a Grant-in-Aid for Scientific Research (C) from the Ministry of Education, Science, Culture, and Sports in Japan (No. 22591922). CR Ackerman BH, 1997, PHARMACOTHERAPY, V17, P482 Adler E, 2000, CELL, V100, P693, DOI 10.1016/S0092-8674(00)80705-9 Bartoshuk LM, 2005, CHEM SENSES, V30, pI218, DOI 10.1093/chemse/bjh192 Brand JG, 2000, LANCET, V356, P1371, DOI 10.1016/S0140-6736(00)02836-1 Clark MPA, 2007, OTOL NEUROTOL, V28, P335, DOI 10.1097/01.mao.0000247820.16325.f0 Doty RL, 2008, DRUG SAFETY, V31, P199 Goins MR, 2004, LARYNGOSCOPE, V114, P1206, DOI 10.1097/00005537-200407000-00015 Goodspeed RG, 1986, CLIN MEASUREMENT TAS, P451 HAUSSERHAUW C, 1987, BRAIN, V110, P339, DOI 10.1093/brain/110.2.339 Heyneman CA, 1996, ANN PHARMACOTHER, V30, P186 Horne J, 2002, CHEM SENSES, V27, P31, DOI 10.1093/chemse/27.1.31 Igarashi A., 2006, J JAPANESE ASS STUDY, V13, P175 Katsura H, 2006, EXP NEUROL, V200, P112, DOI 10.1016/j.expneurol.2006.01.031 Kosugi S, 1998, MOL PHARMACOL, V53, P894 Kosugi S, 2000, EUR J ENDOCRINOL, V143, P471, DOI 10.1530/eje.0.1430471 Kuhn C, 2004, J NEUROSCI, V24, P10260, DOI 10.1523/JNEUROSCI.1225-04.2004 Matsunami H, 2000, NATURE, V404, P601 MILLER SM, 1989, J AFFECT DISORDERS, V17, P291, DOI 10.1016/0165-0327(89)90013-X Mueller KL, 2005, NATURE, V434, P225, DOI 10.1038/nature03352 Nakazato Y, 2008, INTERNAL MED, V47, P877, DOI 10.2169/internalmedicine.47.0735 Nakazato Y, 2006, J NEUROL NEUROSUR PS, V77, P405, DOI 10.1136/jnnp.2005.073726 SCHIFFMAN SS, 1979, PHYSIOL BEHAV, V23, P1, DOI 10.1016/0031-9384(79)90113-6 Tessema B, 2006, ANN OTO RHINOL LARYN, V115, P18 TOMITA H, 2002, ACTA OTO-LARYNGOL, V546, P164 Tsuda M, 2003, NATURE, V424, P778, DOI 10.1038/nature01786 Yanagisawa K, 1998, PHYSIOL BEHAV, V63, P329, DOI 10.1016/S0031-9384(97)00423-X Yung M, 2008, OTOL NEUROTOL, V29, P661, DOI 10.1097/MAO.0b013e3181778211 NR 27 TC 2 Z9 2 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD FEB PY 2012 VL 121 IS 2 BP 113 EP 118 PG 6 WC Otorhinolaryngology SC Otorhinolaryngology GA 894ZB UT WOS:000300464900008 PM 22397221 ER PT J AU Zou, J Poe, D Ramadan, UA Pyykko, I AF Zou, Jing Poe, Dennis Ramadan, Usama Abo Pyykko, Ilmari TI Oval Window Transport of Gd-DOTA From Rat Middle Ear to Vestibulum and Scala Vestibuli Visualized by In Vivo Magnetic Resonance Imaging SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE contrast agent; drug delivery; inner ear; magnetic resonance imaging; middle ear; oval window; vestibule ID INTRATYMPANIC GENTAMICIN THERAPY; MENIERES-DISEASE; INNER-EAR; OTITIS-MEDIA; LIPID NANOCAPSULES; PRUSSAKS SPACE; MEMBRANE; COMMUNICATION; INJECTION; DELIVERY AB Objectives: We tested our hypothesis that the oval window (OW) potentially functions as a route to carry substances from the middle ear to the vestibulum and then the scala vestibuli through the annular ligament across the stapediovestibular joint. Methods: Gd-DOTA was either injected into the lateral attic compartment of rats with a high-performance polyimide tube in a selective OW delivery group, or administered to the middle ear cavity of two groups of rats in which the OW was either sealed or not sealed. The dynamic uptake of Gd-DOTA in the inner ear was visualized with a 4.7-T magnetic resonance imaging machine. Results: In the selective OW delivery group, Gd-DOTA appeared in the vestibulum and in the basal turn of the scala vestibuli but not in the scala tympani on T1-weighted images acquired at 10 minutes after Gd-DOTA administration (the earliest available time point of magnetic resonance imaging). In the sealed-OW group, immediate uptake of Gd-DOTA was absent in the vestibulum and scala vestibuli. Measurement of the signal ratio of the vestibulum to that of the scala tympani showed that selective OW delivery induced the greatest signal ratio and that sealing of the OW induced the lowest signal ratio. Conclusions: The OW is a genuine and efficient pathway to transport Gd-DOTA from the middle ear to the vestibulum. C1 [Zou, Jing; Poe, Dennis; Pyykko, Ilmari] Univ Tampere Med Sch, Dept Otolaryngol, Tampere 33520, Finland. [Ramadan, Usama Abo] Helsinki Univ Cent Hosp, Dept Neurol, Expt MRI Lab, Helsinki, Finland. RP Zou, J (reprint author), Univ Tampere Med Sch, Dept Otolaryngol, FM1,3rd Floor,Biokatu 6, Tampere 33520, Finland. FU EU [NMP4-CT-2006-026556] FX Supported by the integrated EU project Nanoear (NMP4-CT-2006-026556). CR Baloh RW, 1996, OTOLARYNG HEAD NECK, V114, P586, DOI 10.1016/S0194-5998(96)70251-6 Borkholder DA, 2008, CURR OPIN OTOLARYNGO, V16, P472, DOI 10.1097/MOO.0b013e32830e20db Chia SH, 2004, OTOL NEUROTOL, V25, P544, DOI 10.1097/00129492-200407000-00023 COLEBATCH JG, 1992, NEUROLOGY, V42, P1635 Gianoli GJ, 2008, OTOL NEUROTOL, V29, P13 Goycoolea MV, 1997, MICROSC RES TECHNIQ, V36, P201, DOI 10.1002/(SICI)1097-0029(19970201)36:3<201::AID-JEMT8>3.0.CO;2-R GOYCOOLEA MV, 1995, ACTA OTO-LARYNGOL, V115, P282, DOI 10.3109/00016489509139310 Harner SG, 2001, OTOL NEUROTOL, V22, P210, DOI 10.1097/00129492-200103000-00016 HELLSTROM S, 1984, ACTA OTO-LARYNGOL, P31 HIRATA Y, 1993, ACTA OTO-LARYNGOL, P79 Kaasinen S, 1998, ACTA OTO-LARYNGOL, V118, P294 Laguna-Torres VA, 2011, INFLUENZA OTHER RESP, V5, P123, DOI 10.1111/j.1750-2659.2010.00182.x Lee IS, 2009, CLIN EXP OTORHINOLAR, V2, P145, DOI 10.3342/ceo.2009.2.3.145 Marchioni D, 2010, SURG RADIOL ANAT, V32, P843, DOI 10.1007/s00276-010-0691-8 Ohashi M, 2008, MED MOL MORPHOL, V41, P28, DOI 10.1007/s00795-007-0394-3 Palva T, 2001, INT J PEDIATR OTORHI, V57, P55, DOI 10.1016/S0165-5876(00)00443-2 Rask-Andersen H, 2006, EAR HEARING, V27, P457, DOI 10.1097/01.aud.0000233864.32183.81 SAIJO S, 1984, ACTA OTO-LARYNGOL, V97, P593, DOI 10.3109/00016488409132937 Scheper V, 2009, NANOMEDICINE-UK, V4, P623, DOI [10.2217/nnm.09.41, 10.2217/NNM.09.41] Sea T, 2008, ACTA OTO-LARYNGOL, V128, P639 Silverstein H, 2010, OTOLARYNG HEAD NECK, V142, P570, DOI 10.1016/j.otohns.2009.12.009 Silverstein H, 1999, Ear Nose Throat J, V78, P595 Thomsen J, 2000, EUR ARCH OTO-RHINO-L, V257, P362, DOI 10.1007/s004059900219 YAMAZAKI T, 1988, ARCH OTO-RHINO-LARYN, V245, P170, DOI 10.1007/BF00464021 Zhang Y, 2011, ACTA OTO-LARYNGOL, V131, P1249, DOI 10.3109/00016489.2011.615066 Zou J, 2010, OTOL NEUROTOL, V31, P637, DOI 10.1097/MAO.0b013e3181d2f095 Zou J, 2008, J BIOMED MATER RES B, V87B, P10, DOI 10.1002/jbm.b.31058 Zou J, 2005, AUDIOL NEURO-OTOL, V10, P145, DOI 10.1159/000084024 NR 28 TC 10 Z9 10 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD FEB PY 2012 VL 121 IS 2 BP 119 EP 128 PG 10 WC Otorhinolaryngology SC Otorhinolaryngology GA 894ZB UT WOS:000300464900009 PM 22397222 ER PT J AU Fishman, JM Ansari, T Sibbons, P De Coppi, P Birchall, MA AF Fishman, Jonathan M. Ansari, Tahera Sibbons, Paul De Coppi, Paolo Birchall, Martin A. TI Decellularized Rabbit Cricoarytenoid Dorsalis Muscle for Laryngeal Regeneration SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article; Proceedings Paper CT Meeting of the American-Broncho-Esophagological-Association CY APR 27-28, 2011 CL Chicago, IL SP Amer Broncho Esophagol Assoc DE laryngeal regeneration; scaffold; skeletal muscle; tissue engineering ID EXTRACELLULAR-MATRIX SCAFFOLDS; SKELETAL-MUSCLE; NERVE REGENERATION; CELLS; TRANSPLANTATION; TISSUES; REPAIR AB Objectives: Although considerable progress has been made in regenerative medicine, a quantum step would be the replacement and/or regeneration of functional muscle tissue. For example, although patients' airways can now be successfully replaced with stem cell based techniques, a much greater patient need would be addressed by regeneration of the muscles required for engineering a functional larynx, in which active movement is critical. The rabbit cricoarytenoid dorsalis muscle was chosen for the present study because it is equivalent to the posterior cricoarytenoid muscle, the only significant abductor muscle in human larynges. Methods: Rabbit cricoarytenoid dorsalis muscles were harvested, and different decellularization methods were compared by use of a combination of histologic, immunohistochemical, and molecular techniques. Decellularized scaffolds were implanted into Sprague-Dawley rats as part of a 2-week biocompatibility study to assess immunogenicity. Results: Decellularization with a combination of latrunculin B, potassium iodide, potassium chloride, and deoxyribonuclease resulted in total DNA clearance and reduced levels of major histocompatibility complex class II expression, with relative preservation of the scaffold's structural integrity (collagen, elastin, and glycosaminoglycan content). The scaffolds showed minimal signs of rejection at 2 weeks in a cross-species (xenotransplantation) study. Conclusions: Decellularized laryngeal muscles, which are nonimmunogenic, may provide the optimal scaffold source for the generation of a fully functional tissue-engineered larynx. C1 [Fishman, Jonathan M.; De Coppi, Paolo] UCL, Inst Child Hlth, London WC1N 1EH, England. [Fishman, Jonathan M.; De Coppi, Paolo; Birchall, Martin A.] UCL, Ctr Stem Cells & Regenerat Med, London WC1N 1EH, England. [Fishman, Jonathan M.; Birchall, Martin A.] UCL, Ear Inst, London WC1N 1EH, England. [Fishman, Jonathan M.; Ansari, Tahera; Sibbons, Paul] Northwick Pk Inst Med Res, London, England. [Fishman, Jonathan M.; De Coppi, Paolo] Great Ormond St Hosp Sick Children, London WC1N 3JH, England. [Fishman, Jonathan M.; Birchall, Martin A.] Royal Natl Throat Nose & Ear Hosp, London WC1X 8DA, England. RP Fishman, JM (reprint author), UCL, Inst Child Hlth, 30 Guilford St, London WC1N 1EH, England. CR Badylak SE, 2008, SEMIN IMMUNOL, V20, P109, DOI 10.1016/j.smim.2007.11.003 Baiguera S, 2011, BIOMATERIALS, V32, P4433, DOI 10.1016/j.biomaterials.2011.02.055 Baiguera S, 2010, BIOMATERIALS, V31, P8931, DOI 10.1016/j.biomaterials.2010.08.005 Barnes CA, 2011, BIOMATERIALS, V32, P137 Beattie AJ, 2009, TISSUE ENG PT A, V15, P1119, DOI 10.1089/ten.tea.2008.0162 Birchall M, 2008, TRANSPLANTATION, V85, P1075, DOI 10.1097/TP.0b013e31816a10e4 Birchall MA, 2006, AM J TRANSPLANT, V6, P20, DOI 10.1111/j.1600-6143.20005.01144.x Borschel GH, 2004, PLAST RECONSTR SURG, V113, P595, DOI 10.1097/01.PRS.0000101064.62289.2F Brown BN, 2010, BIOMATERIALS, V31, P428, DOI 10.1016/j.biomaterials.2009.09.061 Conconi MT, 2005, TRANSPLANT INT, V18, P727, DOI 10.1111/j.1432-2277.2005.00082.x Conconi MT, 2005, BIOMATERIALS, V26, P2567, DOI 10.1016/j.biomaterials.2004.07.035 Conconi MT, 2009, J BIOMED MATER RES A, V89A, P304, DOI 10.1002/jbm.a.31982 Crapo PM, 2011, BIOMATERIALS, V32, P3233, DOI 10.1016/j.biomaterials.2011.01.057 De Coppi P, 2006, TISSUE ENG, V12, P1929 Fishman JM, 2011, COMPREHENSIVE BIOMAT, V5, P509 Gilbert TW, 2006, BIOMATERIALS, V27, P3675, DOI 10.1016/j.biomaterials.2006.02.014 Gillies AR, 2011, TISSUE ENG PART C-ME, V17, P383, DOI 10.1089/ten.TEC.2010.0438 Go T, 2010, J THORAC CARDIOV SUR, V139, P437, DOI 10.1016/j.jtcvs.2009.10.002 Kanemaru SI, 2003, ANN OTO RHINOL LARYN, V112, P492 Kingham PJ, 2006, J ANAT, V209, P511, DOI 10.1111/j.1469-7580.2006.00623.x Knott PD, 2011, TRANSPLANTATION, V91, P804, DOI 10.1097/TP.0b013e31820cfd0b Macchiarini P, 2009, LANCET, V373, P462 Macchiarini P, 2008, LANCET, V372, P2023, DOI 10.1016/S0140-6736(08)61598-6 Machingal MA, 2011, TISSUE ENG PT A, V17, P2291, DOI [10.1089/ten.TEA.2010.0682, 10.1089/ten.tea.2010.0682] MEEZAN E, 1975, LIFE SCI, V17, P1721, DOI 10.1016/0024-3205(75)90119-8 Merritt EK, 2010, TISSUE ENG PT A, V16, P1395, DOI 10.1089/ten.TEA.2009.0226 Merritt EK, 2010, TISSUE ENG PT A, V16, P2871, DOI 10.1089/ten.TEA.2009.0826 MERTENS G, 1992, J BIOL CHEM, V267, P20435 Nagata S, 2010, CELL, V140, P619, DOI 10.1016/j.cell.2010.02.014 Rhee HS, 2008, J HISTOCHEM CYTOCHEM, V56, P929, DOI 10.1369/jhc.2008.951756 Rossi CA, 2011, FASEB J, V25, P2296, DOI 10.1096/fj.10-174755 Ryan S, 2003, J ANAT, V202, P421 Vacanti J. P., 1999, LANCET S1, V354, pSI32 Valentin JE, 2009, TISSUE ENG PT A, V15, P1687, DOI 10.1089/ten.tea.2008.0419 Zheng MH, 2005, J BIOMED MATER RES B, V73B, P61, DOI 10.1002/jbm.b.30170 NR 35 TC 6 Z9 7 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD FEB PY 2012 VL 121 IS 2 BP 129 EP 138 PG 10 WC Otorhinolaryngology SC Otorhinolaryngology GA 894ZB UT WOS:000300464900010 PM 22397223 ER PT J AU Uzun, L Balbaloglu, E Akinci, H AF Uzun, Lokman Balbaloglu, Evrim Akinci, Harun TI Garlic-Supplemented Diet Attenuates Gentamicin-Induced Ototoxicity: An Experimental Study SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE garlic; gentamicin; hearing loss; ototoxicity ID INDUCED OXIDATIVE STRESS; AMINOGLYCOSIDE OTOTOXICITY; RENAL DAMAGE; RATS; CONSTITUENTS; EXTRACT; NEPHROTOXICITY; PREVENTION AB Objectives: Gentamicin sulfate is a potent aminoglycoside antibiotic associated with serious side effects, including ototoxicity. Garlic, with its intrinsic antioxidant activity, may prove beneficial in prevention of ototoxicity. In this study, we investigated the effect of a 4% garlic supplemented diet on the ototoxicity induced by gentamicin in rats by using brain stern evoked response audiometry. Methods: Eighteen male Wistar rats with an intact Preyer's reflex and an initial weight of 220 to 260 g were randomly assigned to a group with gentamicin injection and garlic supplementation, a group with gentamicin injection without garlic supplementation, or a control group (6 rats each group). Gentamicin was given by intraperitoneal injection at 120 mg/kg body weight once daily for 16 days. The garlic-supplemented diet was prepared by adding pulverized whole garlic cloves to standard chow in a 4% proportion. After 21 days, hearing thresholds were evaluated by use of brain stem evoked response audiometry at 10 kHz. Results: The mean (+/- SD) amplitudes of the auditory thresholds (sensation level) measured by use of brain stem evoked response audiometry for the group with garlic supplementation, the group without garlic, and the control group were 43.3 +/- 8.16, 78.0 +/- 4.47, and 16.7 +/- 5.16 dB sensation level, respectively. The differences were statistically significant (p < 0.05). Conclusions: A garlic-supplemented diet seems to attenuate aminoglycoside-induced hearing loss. C1 [Uzun, Lokman] Sema Hosp, Dept Otorhinolaryngol Head & Neck Surg, TR-34844 Istanbul, Turkey. [Balbaloglu, Evrim] Anadolu Hosp, Dept Otorhinolaryngol, Zonguldak, Turkey. [Akinci, Harun] Zonguldak Karaelmas Univ, Div Audiol, Dept Otorhinolaryngol, Zonguldak, Turkey. RP Uzun, L (reprint author), Sema Hosp, Dept Otorhinolaryngol Head & Neck Surg, Sahil Yolu Sok 16, TR-34844 Istanbul, Turkey. CR Ali BH, 2003, FOOD CHEM TOXICOL, V41, P1447, DOI 10.1016/S0278-6915(03)00186-8 Amagase H, 2006, J NUTR, V136, p716S Feldman L, 2007, KIDNEY INT, V72, P359, DOI 10.1038/sj.ki.5002295 GUO Z, 1990, Planta Medica, V56, P692, DOI 10.1055/s-2006-961372 Ide N, 1996, PHYTOTHER RES, V10, P340, DOI 10.1002/(SICI)1099-1573(199606)10:4<340::AID-PTR831>3.3.CO;2-W Iqbal M, 1998, FOOD CHEM TOXICOL, V36, P485, DOI 10.1016/S0278-6915(98)00008-8 LACHMANN G, 1994, ARZNEIMITTEL-FORSCH, V44-1, P734 Maldonado PD, 2003, LIFE SCI, V73, P2543, DOI 10.1016/S0024-3205(03)00609-X Maldonado PD, 2003, FREE RADICAL BIO MED, V35, P317, DOI 10.1016/S0891-5849(03)00312-5 Malki Ahmed, 2009, Cancer Biol Ther, V8, P2175 Numagami Y, 1996, NEUROCHEM INT, V29, P135, DOI 10.1016/0197-0186(95)00117-4 Oliveira J A A de, 2004, Otolaryngol Head Neck Surg, V131, P271 Pedraza-Chaverri J, 2000, FREE RADICAL BIO MED, V29, P602, DOI 10.1016/S0891-5849(00)00354-3 Pedraza-Chaverrí José, 2004, BMC Clin Pharmacol, V4, P5, DOI 10.1186/1472-6904-4-5 Pedraza-Chaverri J, 2001, MOL CELL BIOCHEM, V216, P9, DOI 10.1023/A:1011050619406 Pedraza-Chaverri J, 2003, EUR J PHARMACOL, V473, P71, DOI 10.1016/S0014-2999(03)01948-4 RIETZ B, 1993, MOL CELL BIOCHEM, V119, P143, DOI 10.1007/BF00926865 Rybak LP, 2007, KIDNEY INT, V72, P931, DOI 10.1038/sj.ki.5002434 Schacht J, 1998, OTOLARYNG HEAD NECK, V118, P674, DOI 10.1177/019459989811800518 SERGI B, 2004, ACTA OTO-LARYNGOL, V552, P42 Singh SP, 1995, MUTAT RES-GENET TOX, V345, P147, DOI 10.1016/0165-1218(95)90050-0 Takumida M, 1999, ORL J OTO-RHINO-LARY, V61, P63, DOI 10.1159/000027643 Wei ZH, 1998, NUTR RES, V18, P61, DOI 10.1016/S0271-5317(97)00200-5 Wu WJ, 2002, AUDIOL NEURO-OTOL, V7, P171, DOI 10.1159/000058305 NR 24 TC 3 Z9 3 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD FEB PY 2012 VL 121 IS 2 BP 139 EP 143 PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA 894ZB UT WOS:000300464900011 PM 22397224 ER PT J AU Nuss, RC Ward, J Recko, T Huang, L Woodnorth, GH AF Nuss, Roger C. Ward, Jessica Recko, Thomas Huang, Lin Woodnorth, Geralyn Harvey TI Validation of a Pediatric Vocal Fold Nodule Rating Scale Based on Digital Video Images SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE child; digital video image; rating scale; vocal fold nodule ID SCHOOL-AGE-CHILDREN; CHRONIC HOARSENESS AB Objectives: We sought to create a validated scale of vocal fold nodules in children, based on digital video clips obtained during diagnostic fiberoptic laryngoscopy. Methods: We developed a 4-point grading scale of vocal fold nodules in children, based upon short digital video clips. A tutorial for use of the scale, including schematic drawings of nodules, static images, and 10-second video clips, was presented to 36 clinicians with various levels of experience. The clinicians then reviewed 40 short digital video samples from pediatric patients evaluated in a voice clinic and rated the nodule size. Statistical analysis of the ratings provided inter-rater reliability scores. Results: Thirty-six clinicians with various levels of experience rated a total of 40 short video clips. The ratings of experienced raters (14 pediatric otolaryngology attending physicians and pediatric otolaryngology fellows) were compared with those of inexperienced raters (22 nurses, medical students, otolaryngology residents, physician assistants, and pediatric speech-language pathologists). The overall intraclass correlation coefficient for the ratings of nodule size was quite good (0.62; 95% confidence interval, 0.52 to 0.74). The p value for experienced raters versus inexperienced raters was 0.1345, indicating no statistically significant difference in the ratings by these two groups. The intraclass correlation coefficient for intra-rater reliability was very high (0.89). Conclusions: The use of a dynamic scale of pediatric vocal fold nodule size most realistically represents the clinical assessment of nodules during an office visit. The results of this study show a high level of agreement between experienced and inexperienced raters. This scale can be used with a high level of reliability by clinicians with various levels of experience. A validated grading scale will help to assess long-term outcomes of pediatric patients with vocal fold nodules. C1 [Nuss, Roger C.; Ward, Jessica; Recko, Thomas; Woodnorth, Geralyn Harvey] Childrens Hosp, Dept Otolaryngol & Commun Enhancement, Boston, MA 02115 USA. [Huang, Lin] Childrens Hosp, Clin Res Program, Boston, MA 02115 USA. [Nuss, Roger C.; Ward, Jessica; Recko, Thomas; Woodnorth, Geralyn Harvey] Harvard Univ, Sch Med, Dept Otol & Laryngol, Boston, MA 02115 USA. RP Nuss, RC (reprint author), Childrens Hosp, Dept Otolaryngol & Commun Enhancement, 300 Longwood Ave, Boston, MA 02115 USA. CR BAYNES RA, 1966, J SPEECH HEAR DISORD, V31, P172 De Bodt MS, 2007, J VOICE, V21, P151, DOI 10.1016/j.jvoice.2005.11.006 HIRSCHBERG J, 1995, INT J PEDIATR OTORHI, V32, pS109, DOI 10.1016/0165-5876(94)01149-R Kempster GB, 2009, AM J SPEECH-LANG PAT, V18, P124, DOI 10.1044/1058-0360(2008/08-0017) Kilic MA, 2004, INT J PEDIATR OTORHI, V68, P409, DOI 10.1016/j.ijporl.2003.11.005 LANDIS JR, 1977, BIOMETRICS, V33, P363, DOI 10.2307/2529786 Nuss RC, 2003, 18 ANN M AM SOC PED, P20 Nuss RC, 2010, ANN OTO RHINOL LARYN, V119, P651 Shah RK, 2007, OTOLARYNG HEAD NECK, V136, P193, DOI 10.1016/j.otohns.2006.11.003 SILVERMAN EM, 1975, J SPEECH HEAR DISORD, V40, P211 NR 10 TC 4 Z9 4 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD JAN PY 2012 VL 121 IS 1 BP 1 EP 6 PG 6 WC Otorhinolaryngology SC Otorhinolaryngology GA 879TS UT WOS:000299355700001 PM 22312920 ER PT J AU Teixido, M Kung, B Rosowski, JJ Merchant, SN AF Teixido, Michael Kung, Brian Rosowski, John J. Merchant, Saumil N. TI Histopathology of the Temporal Bone in a Case of Superior Canal Dehiscence Syndrome SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE aural fullness; otopathology; superior canal dehiscence; temporal bone histopathology; tinnitus ID TULLIO PHENOMENON; HEARING; VERTIGO; SOUND AB Objectives: We describe the histopathologic findings in the temporal bones of a patient who had, during life, received a diagnosis of superior canal dehiscence (SCD) syndrome. Methods: The patient was found to have SCD syndrome at 59 years of age. She became a temporal bone donor, and died of unrelated causes at 62 years of age. Both temporal bones were prepared in celloidin and examined by light microscopy. Results: The patient developed bilateral aural fullness, pulsatile tinnitus, and difficulty tolerating loud noises after minor head trauma at 53 years of age. The symptoms were worse on the right. She also had Valsalva-induced dizziness and eye movements, as well as sound-induced dizziness (more prominent on the right). Audiometry showed a small air-bone gap of 10 dB in the right ear. Vestibular evoked myogenic potential testing showed an abnormally low threshold of 66 dB on the right, and a computed tomography scan showed dehiscence of the superior canal on the right. Histopathologic examination of the right ear showed a 1.4 x 0.6-mm dehiscence of bone covering the superior canal. Dura was in direct contact with the endosteum and the membranous duct at the level of the dehiscence. No osteoclastic process was evident within the otic capsule bone surrounding the dehiscence. The left ear showed thin but intact bone over the superior canal. Both ears showed focal microdehiscences of the tegmen tympani and tegmen mastoideum. The auditory and vestibular sense organs on both sides appeared normal. No endolymphatic hydrops was observed. Conclusions: The findings were consistent with the hypothesis put forth by Carey and colleagues that SCD may arise from a failure of postnatal bone development, and that minor trauma may disrupt thin bone or stable dura over the superior canal. C1 [Rosowski, John J.; Merchant, Saumil N.] Massachusetts Eye & Ear Infirm, Dept Otolaryngol, Boston, MA 02114 USA. [Rosowski, John J.; Merchant, Saumil N.] Harvard Univ, Sch Med, Boston, MA USA. [Teixido, Michael; Kung, Brian] Christiana Care Hlth Syst, Dept Otolaryngol, Wilmington, DE USA. RP Merchant, SN (reprint author), Massachusetts Eye & Ear Infirm, Dept Otolaryngol, 243 Charles St, Boston, MA 02114 USA. FU NIH [U24 DC011943] FX From the Department of Otolaryngology, Christiana Care Health System, Wilmington, Delaware (Teixido, Kung), and the Department of Otolaryngology, Massachusetts Eye and Ear Infirmary and Harvard Medical School, Boston, Massachusetts (Rosowski, Merchant). This work was supported by NIH grant U24 DC011943. CR Arts HA, 2009, OTOL NEUROTOL, V30, P79, DOI 10.1097/MAO.0b013e31818d1b51 Brantberg K, 2001, ACTA OTO-LARYNGOL, V121, P68 Carey JP, 2000, ARCH OTOLARYNGOL, V126, P137 Cox Kenneth M, 2003, Am J Audiol, V12, P11, DOI 10.1044/1059-0889(2003/004) Hillman TA, 2006, OTOLARYNG HEAD NECK, V134, P431, DOI 10.1016/j.otohns.2005.10.033 Merchant SN, 2010, SCHUKNECHTS PATHOLOG, P3 Mikulec AA, 2004, OTOL NEUROTOL, V25, P121, DOI 10.1097/00129492-200403000-00007 Minor LB, 1998, ARCH OTOLARYNGOL, V124, P249 Minor LB, 2005, LARYNGOSCOPE, V115, P1717, DOI 10.1097/01.mlg.000178324.55729.b7 Ostrowski VB, 2001, OTOL NEUROTOL, V22, P61, DOI 10.1097/00129492-200101000-00012 Songer JE, 2007, J ACOUST SOC AM, V122, P943, DOI 10.1121/1.2747158 Strupp M, 2000, NERVENARZT, V71, P138, DOI 10.1007/s001150050021 Teixido MT, 2008, OTOLARYNG HEAD NECK, V139, P405, DOI 10.1016/j.otohns.2008.06.023 Watson SRD, 2000, NEUROLOGY, V54, P722 NR 14 TC 3 Z9 3 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD JAN PY 2012 VL 121 IS 1 BP 7 EP 12 PG 6 WC Otorhinolaryngology SC Otorhinolaryngology GA 879TS UT WOS:000299355700002 PM 22312921 ER PT J AU Westbrook, BJ Wilhelm, M Shvidler, J AF Westbrook, Benjamin J. Wilhelm, Michael Shvidler, Joseph TI Novel Use of a Suction-Irrigation Device to Remove Impacted Blood Clot From the Airway SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article; Proceedings Paper CT Meeting of the American-Broncho-Esophagological-Association CY APR 27-28, 2011 CL Chicago, IL SP Amer Broncho Esophagol Assoc DE airway blood clot; airway foreign body; impacted foreign body; tracheal blood clot AB Objectives: We sought to describe the novel use of a suction-irrigation device to remove a large blood clot that was causing critical obstruction of the trachea and main stem bronchi in our patient. Methods: A large-bore suction-irrigation device designed for use in gynecologic cases was adapted for use in removal of an obstructing blood clot in the face of patient decompensation after several unsuccessful attempts at removal with standard otolaryngological instruments. Results: The tracheal obstruction and the significant bronchial obstructions were successfully removed with the suction-irrigation device. The patient's ventilatory status quickly stabilized. He was extubated the following day and discharged home. Conclusions: The suction-irrigation device proved highly successful in removing a large blood clot from the airway. A similarly designed device made specifically for the airway could prove useful in similar cases in the future. C1 [Westbrook, Benjamin J.] Madigan Army Med Ctr, Dept Otolaryngol Head & Neck Surg, ATTN MCHJ SET, Tacoma, WA 98431 USA. RP Westbrook, BJ (reprint author), Madigan Army Med Ctr, Dept Otolaryngol Head & Neck Surg, ATTN MCHJ SET, Tacoma, WA 98431 USA. CR Arney KL, 1999, CHEST, V115, P293, DOI 10.1378/chest.115.1.293 Collins KA, 2005, AM J FOREN MED PATH, V26, P327, DOI 10.1097/01.paf.0000188078.43884.77 Morris LGT, 2010, ANZ J SURG, V80, P473, DOI 10.1111/j.1445-2197.2010.05329.x NR 3 TC 0 Z9 0 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD JAN PY 2012 VL 121 IS 1 BP 13 EP 15 PG 3 WC Otorhinolaryngology SC Otorhinolaryngology GA 879TS UT WOS:000299355700003 PM 22312922 ER PT J AU Tan, S Rotenberg, B AF Tan, Susan Rotenberg, Brian TI Functional Outcomes After Lateral Crural J-Flap Repair of External Nasal Valve Collapse SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article; Proceedings Paper CT Meeting of the Canadian-Society-of-Otolaryngology-Head-and-Neck-Surgery CY MAY 22-24, 2011 CL Victoria, CANADA SP Canadian Soc Otolaryngol Head & Neck Surg DE external nasal valve; nasal obstruction; nasal valve collapse; validated outcome ID QUALITY-OF-LIFE; RHINOPLASTY; SUSPENSION; SURGERY AB Objectives: We evaluated the lateral crural J-flap technique in the surgical repair of external nasal valve collapse with standardized and validated outcome measurements. Methods: Prospective data were gathered on consecutive cases, performed by a single surgeon between 2007 and 2010, of adult patients who underwent a lateral crural approach to repair of external nasal valve collapse. Data were collected on diagnosis, surgical outcomes, and complications. Outcome measures included the Nasal Obstructive Symptom Evaluation and the Rhinoplasty Outcome Evaluation. Results: Fifteen patients were included in the study. Their follow-ups ranged from 9 to 13 months. All patients had statistically significant improvements in Nasal Obstructive Symptom Evaluation scores. There was no significant change in perceived nasal appearance after surgery as measured by the Rhinoplasty Outcome Evaluation. There were no surgical complications. Conclusions: The lateral crural J-flap approach to repair of external nasal valve collapse is a technically straightforward and relatively safe procedure. The efficacy is excellent at the 1-year follow-up examination. C1 [Rotenberg, Brian] Univ Western Ontario, St Josephs Hlth Ctr, Dept Otolaryngol Head & Neck Surg, London, ON N6A 4V2, Canada. RP Rotenberg, B (reprint author), Univ Western Ontario, St Josephs Hlth Ctr, Dept Otolaryngol Head & Neck Surg, 268 Grosvenor St,Rm E3-104, London, ON N6A 4V2, Canada. CR Andre RF, 2009, CLIN OTOLARYNGOL, V34, P518, DOI 10.1111/j.1749-4486.2009.02042.x Bloching MB, 2007, GMS CURRENT TOPICS O, V6, P1 BRIDGER GP, 1970, ARCHIV OTOLARYNGOL, V92, P543 Cole P, 2003, AM J RHINOL, V17, P107 Franco Gutierrez V, 2006, ACTA OTORRINOLARINGO, V57, P350 Friedman M, 2003, LARYNGOSCOPE, V113, P381, DOI 10.1097/00005537-200302000-00033 Friedman M, 2004, OTOLARYNG HEAD NECK, V131, P519, DOI 10.1016/j.otohns.2004.03.035 GOODE RL, 1985, LARYNGOSCOPE, V95, P546 Khosh Maurice M, 2004, Arch Facial Plast Surg, V6, P167, DOI 10.1001/archfaci.6.3.167 Meningaud JP, 2008, PLAST RECONSTR SURG, V121, P251, DOI 10.1097/01.prs.0000293866.57517.d4 Most SP, 2006, ARCH FACIAL PLAST S, V8, P306, DOI 10.1001/archfaci.8.5.306 O'Halloran LR, 2003, OTOLARYNG HEAD NECK, V128, P640, DOI 10.1016/S0194-5998(03)00096-2 Paniello RC, 1996, ARCH OTOLARYNGOL, V122, P1342 Rhee JS, 2005, LARYNGOSCOPE, V115, P437, DOI 10.1097/01.mlg.0000157831.46250 Rhee JS, 2008, OTOLARYNG HEAD NECK, V139, P10, DOI 10.1016/j.otohns.2008.02.007 Spielmann PM, 2009, LARYNGOSCOPE, V119, P1281, DOI 10.1002/lary.20495 Stewart MG, 2004, OTOLARYNG HEAD NECK, V130, P157, DOI 10.1016/j.otohns.2003.09.016 TEICHGRAEBER JF, 1995, LARYNGOSCOPE, V105, P760, DOI 10.1288/00005537-199507000-00015 NR 18 TC 0 Z9 0 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD JAN PY 2012 VL 121 IS 1 BP 16 EP 20 PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA 879TS UT WOS:000299355700004 PM 22312923 ER PT J AU Britton, D Yorkston, KM Eadie, T Stepp, CE Ciol, MA Baylor, C Merati, AL AF Britton, Deanna Yorkston, Kathryn M. Eadie, Tanya Stepp, Cara E. Ciol, Marcia A. Baylor, Carolyn Merati, Albert L. TI Endoscopic Assessment of Vocal Fold Movements During Cough SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE cough; measurement; true vocal fold movement ID EXTUBATION OUTCOMES; VOLUNTARY COUGH; MUSCLE-ACTIVITY; DISEASE; DYSFUNCTION; ADDUCTION; ABDUCTION; LARYNX; AIRWAY AB Objectives: Little is known about the function of the true vocal folds (TVFs) during cough. The objective of this study was to determine the reliability of measuring TVF movements during cough and to obtain preliminary normative data for these measures. Methods: Sequential glottal angles associated with TVF adduction and abduction across the phases of cough were analyzed from laryngeal videoendoscopy records of 38 young healthy individuals. Results: The intraobserver and interobserver reliability of 3 experienced measurers was high (intraclass correlation of at least 0.97) for measuring sequential and maximum glottal angles. The TVF abduction velocity during expulsion was significantly higher than the precompression adduction velocity (p = 0.002), but there were no significant differences in maximum angle. No statistically significant differences were seen in maximum TVF angle and velocity when they were compared between the sexes and between the levels of cough strength. True vocal fold closure following expulsion occurred in 42% of soft coughs and in 57% of moderate to hard coughs. Conclusions: The TVF abduction angles during cough can be reliably measured from laryngeal videoendoscopy in young healthy individuals. The TVF movements are faster for expulsion abduction than for precompression adduction, but the extents of abduction are similar. To validly determine the cough phase duration, simultaneous measures of airflow are needed. C1 [Britton, Deanna; Yorkston, Kathryn M.; Stepp, Cara E.; Ciol, Marcia A.; Baylor, Carolyn] Univ Washington, Dept Rehabil Med, Seattle, WA 98195 USA. [Eadie, Tanya; Merati, Albert L.] Univ Washington, Dept Speech & Hearing Sci, Seattle, WA 98195 USA. [Stepp, Cara E.] Univ Washington, Dept Comp Sci & Engn, Seattle, WA 98195 USA. [Merati, Albert L.] Univ Washington, Dept Otolaryngol Head & Neck Surg, Seattle, WA 98195 USA. RP Britton, D (reprint author), Univ Washington, Dept Rehabil Med, 1959 NE Pacific St,Campus Box 356154, Seattle, WA 98195 USA. FU New Century Scholarship; American Speech-Language-Hearing Association Foundation; National Institutes of Health [5T32DC000033] FX From the Departments of Rehabilitation Medicine (Britton, Yorkston, Stepp, Ciol, Baylor), Speech and Hearing Sciences (Eadie, Merati), Computer Science and Engineering (Stepp), and Otolaryngology Head and Neck Surgery (Merlin), University of Washington, Seattle, Washington. This work was partially supported by a New Century Scholarship and Research Stipend from the American Speech-Language-Hearing Association Foundation and by National Institutes of Health grant 5T32DC000033. Department of Speech and Hearing Sciences, University of Washington. CR BACH JR, 1995, ARCH PHYS MED REHAB, V76, P828, DOI 10.1016/S0003-9993(95)80547-8 Boitano LJ, 2006, RESPIR CARE, V51, P913 Cooke A, 1997, J VOICE, V11, P12, DOI 10.1016/S0892-1997(97)80019-7 Dailey SH, 2005, LARYNGOSCOPE, V115, P178, DOI 10.1097/01.mlg.0000150701.46377.df Hadjikoutis S, 2001, ACTA NEUROL SCAND, V103, P207, DOI 10.1034/j.1600-0404.2001.103004207.x Hammond CAS, 2001, NEUROLOGY, V56, P502 Happel KI, 2004, SEM RESP CRIT CARE M, V25, P43 Hillel AD, 2001, LARYNGOSCOPE, V111, P1, DOI 10.1097/00005537-200104001-00001 Humbert Ianessa A, 2008, Laryngoscope, V118, P14 Kawasaki A, 2001, AURIS NASUS LARYNX, V28, P75, DOI 10.1016/S0385-8146(00)00087-0 Martin Bonnie J. W., 1993, Dysphagia, V8, P11, DOI 10.1007/BF01351472 Miller MR, 2005, EUR RESPIR J, V26, P319, DOI 10.1183/09031936.05.00034805 MONSEN RB, 1977, J ACOUST SOC AM, V62, P981, DOI 10.1121/1.381593 Pitts T, 2008, DYSPHAGIA, V23, P297, DOI 10.1007/s00455-007-9144-x Poletto CJ, 2004, J APPL PHYSIOL, V97, P858, DOI 10.1152/japplphysiol.00087.2004 SHROUT PE, 1979, PSYCHOL BULL, V86, P420, DOI 10.1037//0033-2909.86.2.420 Smina M, 2003, CHEST, V124, P262, DOI 10.1378/chest.124.1.262 Stepp CE, 2010, J ACOUST SOC AM, V127, P3166, DOI 10.1121/1.3365257 Su WL, 2010, CHEST, V137, P777, DOI 10.1378/chest.07-2808 VONLEDEN H, 1965, ARCHIV OTOLARYNGOL, V81, P616 Waters KA, 1996, OTOLARYNG HEAD NECK, V114, P554, DOI 10.1016/S0194-5998(96)70246-2 WOODSON GE, 1993, LARYNGOSCOPE, V103, P1227 NR 22 TC 4 Z9 4 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD JAN PY 2012 VL 121 IS 1 BP 21 EP 27 PG 7 WC Otorhinolaryngology SC Otorhinolaryngology GA 879TS UT WOS:000299355700005 PM 22312924 ER PT J AU Bohnenkamp, TA Forrest, K Klaben, BK Stager, J AF Bohnenkamp, Todd A. Forrest, Karen Klaben, Bernice K. Stager, Joel TI Chest Wall Kinematics During Speech Breathing in Tracheoesophageal Speakers SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE alaryngeal speech; laryngectomy; respiration ID TOTAL LARYNGECTOMY; AIRWAY-RESISTANCE; PULMONARY-FUNCTION; VOICE PROSTHESIS; VOCAL LOUDNESS; LUNG-VOLUMES; RIB CAGE; REHABILITATION; INTENSITY; PRESSURE AB Objectives: The purpose of the present study was to determine how tracheoesophageal (TE) speakers manipulate the chest wall (rib cage and abdomen) to speak and how respiratory compromise (chronic obstructive pulmonary disease; COPD) and task variables influence those behaviors. Methods: The chest wall movements of 11 male TE speakers (5 with COPD and 6 without COPD) were measured during tidal breathing, spontaneous speech, and reading. Repeated-measures multivariate analyses were used to compare breathing behaviors across speech tasks and by respiratory health. Additional repeated-measures multivariate analyses and 1-way analyses of variance were conducted on temporal, aerodynamic, and linguistic measures. Results: There was a significant main effect of task and a significant interaction effect of COPD and task on chest wall movements. Rib cage movements varied by task, whereas abdominal movements were as predicted. There was a significant difference in utterance length by task. There were no main effects of COPD on the chest wall and no significant group differences in utterance length, aerodynamic measures, or intelligibility. The TE speakers were generally accurate in inspiring at appropriate linguistic boundaries. Conclusions: The results suggest that there is robust control for speech breathing following laryngectomy, but that there is also increased effort within the chest wall. Implications for future research considerations are discussed. C1 [Bohnenkamp, Todd A.; Forrest, Karen] Indiana Univ, Dept Speech & Hearing Sci, Bloomington, IN 47405 USA. [Stager, Joel] Indiana Univ, Sch Hlth Phys Educ & Recreat, Bloomington, IN USA. [Klaben, Bernice K.] Univ Cincinnati Voice & Swallowing Ctr, Cincinnati, OH USA. RP Bohnenkamp, TA (reprint author), Univ No Iowa, Dept Commun Sci & Disorders, 1555 W 27th St,231 Commun Arts Ctr, Cedar Falls, IA 50614 USA. FU Indiana University Department of Speech and Hearing Sciences FX From the Department of Speech and Hearing Sciences (Bohnenkamp. Forrest) and the School of Health, Physical Education, and Recreation (Stager), Indiana University-Bloomington, Bloomington, Indiana, and the University of Cincinnati Voice and Swallowing Center, Cincinnati, Ohio (Klaben). This study was supported by the Indiana University Department of Speech and Hearing Sciences Departmental Research Support Program. CR Ackerstaff AH, 1995, CLIN OTOLARYNGOL, V20, P547, DOI 10.1111/j.1365-2273.1995.tb01599.x Ackerstaff AH, 1998, LARYNGOSCOPE, V108, P257, DOI 10.1097/00005537-199802000-00018 American Association for Respiratory Care, 1996, RESP CARE, V41, P629 [Anonymous], 2002, TF32 TIME FREQUENCY Bailey EF, 2002, J SPEECH LANG HEAR R, V45, P89, DOI 10.1044/1092-4388(2002/007) Barlow SM, 1999, HDB CLIN SPEECH PHYS, P175 Blom ED, 1998, TRACHEOESOPHAGEAL VO Bohnenkamp TA, 2010, J COMMUN DISORD, V43, P199, DOI 10.1016/j.jcomdis.2010.01.003 Bohnenkamp TA, 2011, ANN OTO RHINOL LARYN, V120, P550 BRIDGES A, 1991, BRIT J DISORD COMMUN, V26, P325 CHADHA TS, 1982, AM REV RESPIR DIS, V125, P644 Eksteen EC, 2003, J OTOLARYNGOL, V32, P250, DOI 10.2310/7070.2003.41731 Elving GJ, 2002, ANN OTO RHINOL LARYN, V111, P200 Fairbanks G, 1960, VOICE ARTICULATION D FRANK NR, 1957, J CLIN INVEST, V36, P1680, DOI 10.1172/JCI103569 Gelfer C.E., 1983, VOCAL FOLD PHYSL BIO, P113 GREGOR RT, 1984, ACTA OTO-LARYNGOL, V97, P177, DOI 10.3109/00016488409130978 Hess MM, 1999, LARYNGOSCOPE, V109, P988, DOI 10.1097/00005537-199906000-00027 HIXON TJ, 1973, J SPEECH HEAR RES, V16, P78 HIXON TJ, 1976, J SPEECH HEAR RES, V19, P297 HOIT JD, 1987, J SPEECH HEAR RES, V30, P351 HOLMES LC, 1994, J SPEECH HEAR RES, V37, P789 Huber JE, 2008, J SPEECH LANG HEAR R, V51, P651, DOI 10.1044/1092-4388(2008/047) Huber JE, 2008, RESP PHYSIOL NEUROBI, V164, P323, DOI 10.1016/j.resp.2008.08.007 LEE L, 1993, AM REV RESPIR DIS, V147, P1199 McAuliffe MJ, 2000, ARCH OTOLARYNGOL, V126, P705 MCFARLAND DH, 1992, J SPEECH HEAR RES, V35, P971 MOON JB, 1987, J SPEECH HEAR RES, V30, P387 Motta S, 2001, ARCH OTOLARYNGOL, V127, P700 MURTY GE, 1991, CLIN OTOLARYNGOL, V16, P25, DOI 10.1111/j.1365-2273.1991.tb01937.x Searl J, 2007, ANN OTO RHINOL LARYN, V116, P304 (SEER) Program - Surveillance Epidemiology and End Results, 2002, SEER PROGR SURV EP E SHARP JT, 1977, AM REV RESPIR DIS, V115, P47 SINGER MI, 1980, ANN OTO RHINOL LARYN, V89, P529 SPERRY EE, 1992, J SPEECH HEAR RES, V35, P1246 Stepp CE, 2008, ANN OTO RHINOL LARYN, V117, P557 TODISCO T, 1984, RESPIRATION, V45, P303 TOGAWA K, 1980, ARCH OTO-RHINO-LARYN, V229, P69, DOI 10.1007/BF00453753 Usui N, 1979, Auris Nasus Larynx, V6, P87 vandenHoogen FJA, 1996, ACTA OTO-LARYNGOL, V116, P913 Ward E.C., 2007, ASIA PACIFIC J SPEEC, V10, P33 WEINBERG B, 1982, J SPEECH HEAR DISORD, V47, P194 WEINBERG B, 1982, J SPEECH HEAR DISORD, V47, P441 WINKWORTH AL, 1994, J SPEECH HEAR RES, V37, P535 WINKWORTH AL, 1995, J SPEECH HEAR RES, V38, P124 Yorkston K. M., 1996, SENTENCE INTELLIGIBI NR 46 TC 1 Z9 1 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD JAN PY 2012 VL 121 IS 1 BP 28 EP 37 PG 10 WC Otorhinolaryngology SC Otorhinolaryngology GA 879TS UT WOS:000299355700006 PM 22312925 ER PT J AU Potash, A Hoffman, HT AF Potash, Andrea Hoffman, Henry T. TI Retrograde Sialendoscopy: A New Technique for Avoiding Retained Ductal Stones SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article; Proceedings Paper CT Combined Sectional Meeting of the Triological-Society CY FEB 04-07, 2010 CL Orlando, FL SP Triol Soc DE retained stone; retrograde sialendoscopy; sialadenitis; sialolithiasis; submandibular gland; Wharton's duct ID SALIVARY-GLAND; MANAGEMENT; SIALOLITHIASIS; SIALOENDOSCOPY; EXPERIENCE; EXCISION; CALCULI AB Objectives: Recurrent infection from stones retained in Wharton's duct after submandibular gland resection warrants intraoperative attention to the duct remnant. Our hypothesis was that retrograde sialendoscopy would help ensure complete stone removal in submandibular gland removal for sialolithiasis. Methods: We reviewed 9 sequential cases of submandibular sialolithiasis treated surgically via open procedures at a tertiary care center by a single surgeon between November 2007 and December 2009. The review focused on the clinical history and intraoperative findings. Results: We identified successful application of a new technique of retrograde sialendoscopy performed to detect and remove stones that were retained in Wharton's duct at the time of submandibular gland resection. An index case of complications from a stone retained after submandibular gland resection is presented in a sequential series of cases in which retrograde sialendoscopy was developed. Conclusions: Retrograde sialendoscopy is a novel technique that is useful as an adjunct to standard submandibular gland resection in the management of sialolithiasis. C1 [Potash, Andrea; Hoffman, Henry T.] Univ Iowa Hosp & Clin, Dept Otolaryngol Head & Neck Surg, Iowa City, IA 52242 USA. RP Hoffman, HT (reprint author), Univ Iowa Hosp & Clin, Dept Otolaryngol Head & Neck Surg, 200 Hawkins Dr,21264 PFP, Iowa City, IA 52242 USA. CR Brown JE, 2002, CARDIOVASC INTER RAD, V25, P345, DOI 10.1007/s00270-002-1952 Gallo O, 2001, CONTROVERSIES MANAGE, P297 Geisthoff Urban W, 2009, Otolaryngol Clin North Am, V42, P1029, DOI 10.1016/j.otc.2009.08.004 Hoffman H, 1999, COMPREHENSIVE MANAGE, P1163 Iro H, 2009, LARYNGOSCOPE, V119, P263, DOI 10.1002/lary.20008 Marchal F, 2007, LARYNGOSCOPE, V117, P373, DOI 10.1097/mlg.0b013e31802c06e9 Marchal F, 2003, ARCH OTOLARYNGOL, V129, P951, DOI 10.1001/archotol.129.9.951 Markiewicz MR, 2007, J LARYNGOL OTOL, V121, P182, DOI 10.1017/S0022215106003525 McGurk M, 2005, BRIT J SURG, V92, P107, DOI 10.1002/bjs.4789 MILTON CM, 1986, ANN ROY COLL SURG, V68, P148 Nahlieli O, 1997, J ORAL MAXIL SURG, V55, P912, DOI 10.1016/S0278-2391(97)90056-2 Nahlieli O, 2003, ORAL SURG ORAL MED O, V95, P396, DOI 10.1067/moe.2003.145 Nahlieli O, 2006, J AM DENT ASSOC, V137, P1394 Ziegler CM, 2004, BRIT J ORAL MAX SURG, V42, P1, DOI 10.1016/S0266-4356(03)00188-8 NR 14 TC 0 Z9 0 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD JAN PY 2012 VL 121 IS 1 BP 38 EP 43 PG 6 WC Otorhinolaryngology SC Otorhinolaryngology GA 879TS UT WOS:000299355700007 PM 22312926 ER PT J AU Han, KD Seruya, M Oh, AK Zalzal, GH Preciado, DA AF Han, Kevin D. Seruya, Mitchel Oh, Albert K. Zalzal, George H. Preciado, Diego A. TI "Natural" Decannulation in Patients With Robin Sequence and Severe Airway Obstruction SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article; Proceedings Paper CT Meeting of the American-Cleft-Palate-and-Craniofacial-Association CY APR 05-09, 2011 CL San Juan, PR SP Amer Cleft Palate & Craniofacial Assoc DE airway management; decannulation; Robin sequence; tracheostomy; upper airway obstruction ID MANDIBULAR DISTRACTION OSTEOGENESIS; ISOLATED ROBIN,PIERRE SEQUENCE; TREATMENT MODALITIES; TRACHEOSTOMY; INFANTS; EXPERIENCE; MANAGEMENT; CHILDREN; TONGUE; LIFE AB Objectives: Airway management in infants with Robin sequence (RS) remains controversial, ranging from conservative to operative methods. In some centers, tracheostomy remains the mainstay for those infants with severe respiratory obstruction. The goals of this retrospective case cohort study were to determine the length of time to decannulation without further surgical intervention (ie, "natural" decannulation) in patients with severe RS who underwent tracheostomy and to investigate potential factors associated with successful decannulation. Methods: We reviewed all infants with RS treated at a large tertiary center from 1994 to 2010. Patients who had undergone tracheostomy were identified. Baseline demographics, complications, deaths, and time to "natural" decannulation were recorded. Statistical analysis was performed with univariate analysis and Kaplan-Meier log-rank tests. Results: Of 61 infants with RS with obstructive events, 25 infants (14 with isolated RS and 11 with syndromic RS) required tracheostomy. At a mean follow-up of 4 years, the rate of tracheostomy-specific complications was 52%; the tracheostomy-specific mortality rate was 12%. Overall, 13 of 25 infants (52%) were "naturally" decannulated, with a median time to decannulation of 97 months. Patients with syndromic RS had a significantly longer median time to decannulation than did those with isolated RS (more than 73 months versus 19 months, respectively; p = 0.019). In addition, patients with long-term tracheostomy dependence had significantly higher maximum carbon dioxide levels before tracheostomy than did patients who were successfully decannulated (82.4 versus 63.2 mEq/L, respectively; p = 0.02). Conclusions: Tracheostomy in infants with RS is associated with inordinately high rates of mortality, morbidity, and long-term tracheostomy dependence, particularly in patients with syndromic RS and in those with high maximum carbon dioxide levels before tracheostomy. C1 [Zalzal, George H.; Preciado, Diego A.] Childrens Natl Med Ctr, Dept Otolaryngol, Washington, DC 20010 USA. [Han, Kevin D.] George Washington Sch Med, Dept Surg, Div Otolaryngol, Washington, DC USA. [Seruya, Mitchel] Georgetown Univ Hosp, Dept Plast Surg, Washington, DC 20007 USA. [Oh, Albert K.] Childrens Natl Med Ctr, Dept Plast Surg, Washington, DC 20010 USA. [Zalzal, George H.; Preciado, Diego A.] Childrens Natl Med Ctr, Dept Pediat, Washington, DC 20010 USA. [Preciado, Diego A.] Childrens Natl Med Ctr, Dept Integrat Syst Biol, Washington, DC 20010 USA. RP Preciado, DA (reprint author), Childrens Natl Med Ctr, Dept Otolaryngol, 111 Michigan Ave NW,4th Floor Main Bldg, Washington, DC 20010 USA. CR Bhat RY, 2006, PEDIATRICS, V118, P101, DOI 10.1542/peds.2005-1873 BUSH PG, 1983, BRIT J PLAST SURG, V36, P434, DOI 10.1016/0007-1226(83)90123-6 CaouetteLaberge L, 1996, CLEFT PALATE-CRAN J, V33, P468, DOI 10.1597/1545-1569(1996)033<0468:SROTFO>2.3.CO;2 CAOUETTELABERGE L, 1994, PLAST RECONSTR SURG, V93, P934, DOI 10.1097/00006534-199404001-00006 Cruz MJ, 1999, LARYNGOSCOPE, V109, P1632, DOI 10.1097/00005537-199910000-00016 Demke J, 2008, INT J PEDIATR OTORHI, V72, P1509, DOI 10.1016/j.ijporl.2008.07.002 Denny A, 2002, PLAST RECONSTR SURG, V109, P896, DOI 10.1097/00006534-200203000-00011 Denny AD, 2001, PLAST RECONSTR SURG, V108, P302, DOI 10.1097/00006534-200108000-00004 DYKES EH, 1985, J PEDIATR SURG, V20, P49, DOI 10.1016/S0022-3468(85)80391-2 FIGUEROA AA, 1991, CLEFT PALATE-CRAN J, V28, P425, DOI 10.1597/1545-1569(1991)028<0425:MTAAIP>2.3.CO;2 FREEZER NJ, 1990, ARCH DIS CHILD, V65, P123 GIANOLI GJ, 1990, ANN OTO RHINOL LARYN, V99, P896 Graf JM, 2008, PEDIATR CRIT CARE ME, V9, P96, DOI 10.1097/01.PCC.0000298641.84257.53 HOFFMAN S, 1965, Plast Reconstr Surg, V35, P504, DOI 10.1097/00006534-196505000-00007 Horta Ricardo, 2009, Congenital Anomalies, V49, P89, DOI 10.1111/j.1741-4520.2009.00229.x Itamoto CH, 2010, BRAZ J OTORHINOLAR, V76, P326, DOI 10.1590/S1808-86942010000300010 Kapp-Simon KA, 2000, CLEFT PALATE-CRAN J, V37, P65, DOI 10.1597/1545-1569(2000)037<0065:MDIIWC>2.3.CO;2 Kirschner RE, 2003, CLEFT PALATE-CRAN J, V40, P13, DOI 10.1597/1545-1569(2003)040<0013:SAMIPR>2.0.CO;2 Kochel J, 2011, CLEFT PALATE-CRAN J, V48, P44, DOI 10.1597/08-273 Lin SY, 2006, ARCH OTOLARYNGOL, V132, P437, DOI 10.1001/archotol.132.4.437 LONGMIRE WP, 1949, AM J DIS CHILD, V78, P750 Marques IL, 2001, CLEFT PALATE-CRAN J, V38, P171, DOI 10.1597/1545-1569(2001)038<0171:CEWIWR>2.0.CO;2 MCCARTHY JG, 1992, PLAST RECONSTR SURG, V89, P1 MOYSON F, 1961, Br J Plast Surg, V14, P187, DOI 10.1016/S0007-1226(61)80035-0 O'Connor Heidi H, 2009, J Intensive Care Med, V24, P187, DOI 10.1177/0885066609332701 O'Connor HH, 2010, RESP CARE, V55, P1076 SADEWITZ VL, 1992, CLEFT PALATE-CRAN J, V29, P246, DOI 10.1597/1545-1569(1992)029<0246:RSCITL>2.3.CO;2 Schaefer RB, 2004, PLAST RECONSTR SURG, V113, P1113, DOI 10.1097/01.PRS.0000110323.50084.21 Schaefer RB, 2003, J CRANIOFAC SURG, V14, P462, DOI 10.1097/00001665-200307000-00011 Senders CW, 2010, ARCH FACIAL PLAST S, V12, P11, DOI 10.1001/archfacial.2009.110 SHER AE, 1992, CLEFT PALATE-CRAN J, V29, P224, DOI 10.1597/1545-1569(1992)029<0224:MOAOIR>2.3.CO;2 Sorin A, 2004, LARYNGOSCOPE, V114, P1815, DOI 10.1097/00005537-200410000-00026 Tibesar RJ, 2010, OTOLARYNG HEAD NECK, V143, P90, DOI 10.1016/j.otohns.2010.02.018 TOMASKI SM, 1995, LARYNGOSCOPE, V105, P111, DOI 10.1288/00005537-199502000-00001 Williams JK, 1999, PLAST RECONSTR SURG, V103, P48, DOI 10.1097/00006534-199901000-00009 NR 35 TC 0 Z9 0 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD JAN PY 2012 VL 121 IS 1 BP 44 EP 50 PG 7 WC Otorhinolaryngology SC Otorhinolaryngology GA 879TS UT WOS:000299355700008 PM 22312927 ER PT J AU Sato, K Umeno, H Nakashima, T AF Sato, Kiminori Umeno, Hirohito Nakashima, Tadashi TI Vocal Fold Stellate Cells in the Human Macula Flava and the Diffuse Stellate Cell System SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article; Proceedings Paper CT Meeting of the American-Broncho-Esophagological-Association CY APR 27-28, 2011 CL Chicago, IL SP Amer Broncho Esophagol Assoc DE diffuse stellate cell system; extrahepatic stellate cell; larynx; macula flava; vocal fold; vocal fold stellate cell ID AGE-RELATED-CHANGES; FUNCTIONAL HISTOLOGY AB Objectives: Hepatic stellate cells (HSCs) are desmin-positive cells with perinuclear vitamin A droplets that play important roles in liver fibrogenesis. Morphologically similar cells have been found at many extrahepatic sites. Consequently, the concept of a diffuse stellate cell system has been proposed. Vocal fold stellate cells (VFSCs) in the human maculae flavae (MFs) are starlike in shape and possess lipid droplets and store vitamin A. In this study, the relationship between the VFSCs in the human MFs and the diffuse stellate cell system was investigated. Methods: Light and electron microscopic investigations and immunohistochemical studies were performed in 5 samples of human adult vocal fold mucosa. Results: The VFSCs showed the morphological features of the HSCs (ie, they were desmin-positive cells with perinuclear vitamin A droplets). Glial fibrillary acidic protein and vimentin were identified in the VFSCs in the MFs. Conclusions: The VFSCs in the human adult MFs express the neural and muscle-associated proteins seen in HSCs. Our present and previous investigations suggest that the VFSCs in the human MFs are a member of the diffuse stellate cell system. The VFSCs are considered a new category of cells in the human vocal fold. The MFs are proposed to be special microenvironments, known as niches, that nurture a pool of VFSCs. C1 [Sato, Kiminori; Umeno, Hirohito; Nakashima, Tadashi] Kurume Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, Kurume, Fukuoka 8300011, Japan. RP Sato, K (reprint author), Kurume Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, 67 Asahi Machi, Kurume, Fukuoka 8300011, Japan. CR Eng FJ, 2000, AM J PHYSIOL-GASTR L, V279, pG7 Geerts A, 2001, SEMIN LIVER DIS, V21, P311, DOI 10.1055/s-2001-17550 Ghadially FN, 1988, ULTRASTRUCT PATHOL, V2, p[329, 413] Sato K, 2003, ACTA OTO-LARYNGOL, V123, P106, DOI 10.1080/0036554021000028077 Sato K, 2004, ANN OTO RHINOL LARYN, V113, P108 SATO K, 1995, ANN OTO RHINOL LARYN, V104, P138 Sato K, 2010, FOLIA PHONIATR LOGO, V62, P178, DOI 10.1159/000314261 Sato K, 2001, ANN OTO RHINOL LARYN, V110, P319 Sato K, 2005, ANN OTO RHINOL LARYN, V114, P517 SATO K, 1995, ANN OTO RHINOL LARYN, V104, P556 Sato K, 2010, FOLIA PHONIATR LOGO, V62, P263, DOI 10.1159/000316962 SATO K, 1995, ANN OTO RHINOL LARYN, V104, P839 Sawitza I, 2009, HEPATOLOGY, V50, P1617, DOI 10.1002/hep.23184 Wake K, 1980, Int Rev Cytol, V66, P303 YAMADA E, 1976, Cell Structure and Function, V1, P201 Yamashita M, 2007, ANN OTO RHINOL LARYN, V116, P847 Zhao LN, 2007, J MOL HISTOL, V38, P53, DOI 10.1007/s10735-007-9078-5 NR 17 TC 3 Z9 3 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD JAN PY 2012 VL 121 IS 1 BP 51 EP 56 PG 6 WC Otorhinolaryngology SC Otorhinolaryngology GA 879TS UT WOS:000299355700009 PM 22312928 ER PT J AU Wright, CT Goudy, SL AF Wright, Charles T. Goudy, Steven L. TI Congenital Laryngomalacia: Symptom Duration and Need for Surgical Intervention SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE laryngomalacia; outcome; stridor ID STRIDOR LARYNGOMALACIA; LARYNX AB Objectives: We undertook to characterize the natural course and duration of stridor and other symptoms associated with laryngomalacia and determine the need for surgical intervention. Methods: A retrospective observational study was performed at a tertiary children's hospital of 120 consecutive cases of congenital laryngomalacia diagnosed and treated by the senior author between July 2005 and June 2009. The patients' symptoms, associated symptoms, and required interventions were recorded. Results: In 115 cases that were managed without surgery, stridor resolved at a mean patient age of 7.6 months. Five patients (4.2%) required supraglottoplasty to resolve their airway obstruction. The patients who required surgery presented emergently to the hospital 80% of the time, and at a younger mean age (45 days) than did patients who did not require surgery (95 days; p = 0.13); these findings suggest the severe nature of their symptoms. Presenting symptoms of dyspnea or accessory muscle use, feeding difficulties, apnea, cyanosis, oxygen desaturation, and failure to thrive were significantly associated with the requirement for operative intervention (all p values less than 0.02). Nonoperative management included placement of a nasogastric tube due to aspiration in 3 patients. Conclusions: The stridor resolved at an average age of 7.6 months of age in patients with laryngomalacia managed without surgery. A young age at presentation and emergent evaluation in the hospital are associated with a higher degree of symptom severity and a higher rate of surgical intervention. Surgical intervention was necessary to treat laryngomalacia in 4.2% of patients in this study population. C1 [Wright, Charles T.; Goudy, Steven L.] Vanderbilt Univ, Med Ctr, Dept Otolaryngol Head & Neck Surg, Nashville, TN 37232 USA. RP Goudy, SL (reprint author), Vanderbilt Univ, Med Ctr, Dept Otolaryngol Head & Neck Surg, 2200 Childrens Way,Doctors Off Tower,7th Floor, Nashville, TN 37232 USA. CR BELMONT JR, 1984, ANN OTO RHINOL LARYN, V93, P430 Ferguson C F, 1970, Otolaryngol Clin North Am, V3, P185 HOLINGER PH, 1967, ANN OTO RHINOL LARYN, V76, P744 LANE RW, 1984, ARCH OTOLARYNGOL, V110, P546 MCSWINEY PF, 1977, ARCH DIS CHILD, V52, P215 Olney DR, 1999, LARYNGOSCOPE, V109, P1770, DOI 10.1097/00005537-199911000-00009 Richter GT, 2008, OTOLARYNG CLIN N AM, V41, P837, DOI 10.1016/j.otc.2008.04.011 ROGER G, 1995, LARYNGOSCOPE, V105, P1111, DOI 10.1288/00005537-199510000-00018 Sutherland GA, 1897, LANCET, V2, P653 Thompson DM, 2007, LARYNGOSCOPE, V117, P1, DOI 10.1097/MLG.0b013e31804a5750 NR 10 TC 4 Z9 4 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD JAN PY 2012 VL 121 IS 1 BP 57 EP 60 PG 4 WC Otorhinolaryngology SC Otorhinolaryngology GA 879TS UT WOS:000299355700010 PM 22312929 ER PT J AU Holmes, AR Chong, K Rodrigues, E Cannon, RD Carpenter, E Ruske, DR Dawes, PJD AF Holmes, Ann R. Chong, Kenneth Rodrigues, Ely Cannon, Richard D. Carpenter, Elizabeth Ruske, Dean R. Dawes, Patrick J. D. TI Yeast Colonization of Voice Prostheses: Pilot Study Investigating Effect of a Bovine Milk Product Containing Anti-Candida albicans Immunoglobulin A Antibodies on Yeast Colonization and Valve Leakage SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE biofilm; Candida albicans; laryngectomy; Provox 2 speech valve ID SILICONE-RUBBER; IN-VITRO; BIOFILM FORMATION; DAIRY-PRODUCTS; CANCER; BACTERIA; ADHESION; VIVO AB Objectives: Our goals were to determine whether a bovine milk product containing anti-Candida albicans immunoglobulin A antibodies ("immune milk") could reduce the adherence of C albicans to voice prosthesis silicone in vitro, and whether administration of the milk could reduce C albicans colonization and voice prosthesis damage in vivo. Methods: An in vitro assay of C albicans attachment to silicone was developed with radiolabeled C albicans. A pilot crossover in vivo trial, over 3 periods of 3 months, was also undertaken for 4 patients with voice prostheses, comparing daily administrations of immune milk and a control milk product. The prosthesis valves were replaced at each change-over and were assessed for wet weight of removable biofilm, yeast numbers in removable biofilm, valve leakage, and valve damage. Results: Immune milk inhibited C albicans adherence to silicone in vitro. However, in a small clinical pilot study, this effect was not replicated. Conclusions: There is scope to further investigate the topical use of immune milk for management of voice prosthesis biofilms. C1 [Holmes, Ann R.; Chong, Kenneth; Rodrigues, Ely; Cannon, Richard D.] Univ Otago, Dept Oral Sci, Sch Dent, Dunedin, New Zealand. [Ruske, Dean R.; Dawes, Patrick J. D.] Univ Otago, Dept Surg Sci, Dunedin Sch Med, Dunedin, New Zealand. [Carpenter, Elizabeth] AgResearch Ltd, Hamilton, New Zealand. RP Dawes, PJD (reprint author), Dunedin Publ Hosp, Dept Otorhinolaryngol Head & Neck Surg, Private Bag 1921, Dunedin, New Zealand. FU Healthcare Otago Charitable Trust; University of Otago; Lottery Health NZ FX From the Department of Oral Sciences, School of Dentistry (Holmes, Chong, Rodrigues, Cannon), and the Department of Surgical Sciences, Dunedin School of Medicine (Ruske, Dawes), University of Otago, Dunedin, and AgResearch Limited, Hamilton (Carpenter), New Zealand. This study was supported by grants from the Healthcare Otago Charitable Trust, the University of Otago, and Lottery Health NZ. Authors Ruske and Dawes are employees of Healthcare Otago. The Healthcare Otago Charitable Trust awards research grants to employees. It is an entity separate from Healthcare Otago. No restrictions are placed in relation to publishing results of studies so funded. CR Bauters TGM, 2002, LARYNGOSCOPE, V112, P708, DOI 10.1097/00005537-200204000-00021 Busscher HJ, 2000, J DAIRY SCI, V83, P641 Busscher HJ, 1997, J BIOMED MATER RES, V34, P201, DOI 10.1002/(SICI)1097-4636(199702)34:2<201::AID-JBM9>3.3.CO;2-G Cannon RD, 2010, METHODS MOL BIOL, V666, P103, DOI 10.1007/978-1-60761-820-1_8 Ell SR, 1996, J LARYNGOL OTOL, V110, P240 Elving GJ, 2002, ANN OTO RHINOL LARYN, V111, P200 Everaert EPJM, 1997, EUR ARCH OTO-RHINO-L, V254, P261, DOI 10.1007/BF02905983 Hodgkinson AJ, 2007, J DAIRY RES, V74, P269, DOI 10.1017/S0022029907002567 Holmes AR, 2002, J DENT RES, V81, P28 Holmes AR, 2006, ORAL SURG ORAL MED O, V102, P488, DOI 10.1016/j.tripleo.2005.10.052 Leunisse C, 2001, J BIOMED MATER RES, V58, P556, DOI 10.1002/jbm.1054 LIU RP, 1990, ORAL SURG ORAL MED O, V70, P724, DOI 10.1016/0030-4220(90)90008-G MAHIEU HF, 1986, ARCH OTOLARYNGOL, V112, P321 MARTIN MV, 1981, J MED MICROBIOL, V14, P457 NEU TR, 1993, BIOMATERIALS, V14, P459, DOI 10.1016/0142-9612(93)90149-V PALMER MD, 1993, LARYNGOSCOPE, V103, P910 Putignani L, 2008, MYCOSES, V51, P209, DOI 10.1111/j.1439-0507.2007.01472.x Rodrigues E, 2009, CLIN OTOLARYNGOL, V34, P481, DOI 10.1111/j.1749-4486.2009.01996.x Rodrigues L, 2007, J BIOMED MATER RES B, V81B, P358, DOI 10.1002/jbm.b.30673 Schwandt LQ, 2005, HEAD NECK-J SCI SPEC, V27, P471, DOI 10.1002/hed.20180 vanWeissenbruch R, 1997, ACTA OTO-LARYNGOL, V117, P452, DOI 10.3109/00016489709113420 NR 21 TC 0 Z9 0 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD JAN PY 2012 VL 121 IS 1 BP 61 EP 66 PG 6 WC Otorhinolaryngology SC Otorhinolaryngology GA 879TS UT WOS:000299355700011 PM 22312930 ER PT J AU Suzuki, M Iwamura, H Kashio, A Sakamoto, T Yamasoba, T AF Suzuki, Mitsuya Iwamura, Hitoshi Kashio, Akinori Sakamoto, Takashi Yamasoba, Tatsuya TI Short-Term Functional and Morphological Changes in Guinea Pig Cochlea Following Intratympanic Application of Burow's Solution SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE acetic acid; aluminum sulfate; basement membrane anionic site; Burow's solution; intratympanic injection; ototoxicity ID GLOMERULAR-BASEMENT-MEMBRANE; ANIONIC SITES; INNER-EAR; LABYRINTH; PH; TURNOVER AB Objectives: Burow's solution, comprising aluminum sulfate and acetic acid, is an otic drug formulation applied to the tympanic cavity. We characterized the relationship between the auditory brain stem response (ABR) thresholds and the area of the capillary basement membrane anionic sites in the stria vascularis after the application of Burow's solution. Methods: We used cationic polyethylenimine (PEI) to observe changes in the capillary basement membrane anionic sites in the stria vascularis. Burow's solution was dropped directly onto the round window membrane and retained for 2 hours. The ABRs were recorded at 4,8, and 20 kHz immediately before surgery and before decapitation. The cochlea was extirpated immediately or 2 days after the surgery and immersed in cationic PEI solution. The PEI distribution associated with the capillary basement membrane anionic sites was measured in the basal and third turns. Results: The ABR threshold shifts at 4,8, and 20 kHz were significantly increased immediately after the surgery, whereas those at 4 and 8 kHz, but not at 20 kHz, had recovered 2 days after the surgery. Further, the PEI distribution was significantly decreased immediately after the surgery and had recovered 2 days after the surgery. Conclusions: Although Burow's solution may cause an acetic low pH in the stria vascularis and a temporary ABR threshold shift at 4 and 8 kHz, the permanent ABR threshold shift at 20 kHz cannot be attributed to the acetic low pH. C1 [Suzuki, Mitsuya] Toho Univ, Sakura Med Ctr, Dept Otolaryngol, Sakura, Chiba 2850841, Japan. [Iwamura, Hitoshi; Kashio, Akinori; Sakamoto, Takashi; Yamasoba, Tatsuya] Univ Tokyo, Dept Otolaryngol, Tokyo 113, Japan. RP Suzuki, M (reprint author), Toho Univ, Sakura Med Ctr, Dept Otolaryngol, 564-1 Shimo Shizu, Sakura, Chiba 2850841, Japan. CR BEAVAN LA, 1989, ARCH BIOCHEM BIOPHYS, V269, P576, DOI 10.1016/0003-9861(89)90143-4 COHEN MP, 1980, J BIOL CHEM, V255, P1767 Hamada M, 1999, ACTA OTO-LARYNGOL, V119, P778 IKEDA K, 1989, AM J OTOLARYNG, V10, P382, DOI 10.1016/0196-0709(89)90032-X Oishi N, 2010, AURIS NASUS LARYNX, V37, P369, DOI 10.1016/j.anl.2009.09.006 Serin GM, 2007, OTOL NEUROTOL, V28, P605 Sushma NJ, 2007, J ENVIRON BIOL, V28, P483 Suzuki M, 2010, ANN OTO RHINOL LARYN, V119, P495 SUZUKI M, 1995, ACTA OTO-LARYNGOL, V115, P747, DOI 10.3109/00016489509139397 Suzuki M, 2001, ANN OTO RHINOL LARYN, V110, P283 Tanaka F, 2003, HEARING RES, V177, P21, DOI 10.1016/S0378-5955(02)00771-2 TOMODA K, 1988, ARCH OTO-RHINO-LARYN, V245, P307, DOI 10.1007/BF00464638 Tsuprun V, 2001, HEARING RES, V157, P65, DOI 10.1016/S0378-5955(01)00278-7 Yamasoba T, 1996, HEARING RES, V102, P116, DOI 10.1016/S0378-5955(96)00159-1 YOSHIMURA A, 1991, NEPHRON, V59, P500 NR 15 TC 0 Z9 0 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD JAN PY 2012 VL 121 IS 1 BP 67 EP 72 PG 6 WC Otorhinolaryngology SC Otorhinolaryngology GA 879TS UT WOS:000299355700012 PM 22312931 ER PT J AU Sinha, P Sharma, SC Agarwal, SP Gupta, SD AF Sinha, Parul Sharma, Suresh C. Agarwal, Shipra Gupta, Siddhartha Datta TI Parapharyngeal Ganglioneuroma With Neurofibromatosis: An Unusual Presentation SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE catecholamine; ganglioneuroma; hypertensive crisis; neurofibromatosis; neurogenic tumor; parapharyngeal space ID FINE-NEEDLE-ASPIRATION; TUMORS; NEUROBLASTOMA; SPACE; NECK AB Objectives: Ganglioneuroma is a rare benign tumor of the sympathetic nervous system that is seldom localized to the head and neck. Rarer still are cases of functional ganglioneuroma with catecholamine production. We report an unusual CSC of a large parapharyngeal space ganglioneuroma in a patient with neurofibromatosis that caused an intraoperative hypertensive crisis in the absence of a neuroblastomatous component hitherto an undocumented complication. Methods: We present a case of functional parapharyngeal ganglioneuroma and review the clinicopathologic and biochemical features of these rare tumors. Results: Fewer than 40 anecdotal cases of parapharyngeal ganglioneuromas have been reported, and there is a lack of adequate literature on the biology and appropriate treatment approach of these tumors. Conclusions: Our case illustrates the importance of vigilant preoperative precautions in the management of neurogenic tumors, particularly ganglioneuromas. These usually nonfunctional tumors can result in sudden intraoperative and postoperative hypertensive crises even in the absence of any preoperative autonomic symptoms. C1 [Sinha, Parul; Sharma, Suresh C.] All India Inst Med Sci, Dept Otorhinolaryngol Head & Neck Surg, New Delhi, India. [Agarwal, Shipra; Gupta, Siddhartha Datta] All India Inst Med Sci, Dept Pathol, New Delhi 110029, India. RP Sinha, P (reprint author), Washington Univ, Dept Otorhinolaryngol Head & Neck Surg, St Louis, MO 63110 USA. CR Adair FE, 1937, RES PUBL ASSOC RES N, V16, P440 Albonico G, 2001, ARCH PATHOL LAB MED, V125, P1217 Baisakhiya Nitish Kumar, 2008, J Pak Med Assoc, V58, P699 Bosse MD, 1944, AM J SURG, V65, P120, DOI 10.1016/S0002-9610(44)90310-7 Califano L, 2001, OTOLARYNG HEAD NECK, V124, P115, DOI 10.1067/mhn.2001.111370 Cannady SB, 2006, INT J PEDIATR OTORHI, V70, P287, DOI 10.1016/j.ijporl.2005.06.020 CLAY RC, 1950, ANN SURG, V132, P147 DANOSOS DA, 1980, B NEW YORK ACAD MED, V56, P616 Foster JH, 1942, ARCHIV OTOLARYNGOL, V36, P372 Friedlander Paul L, 2002, Ear Nose Throat J, V81, P435 Geraci AP, 1998, J CHILD NEUROL, V13, P356 Gill B S, 1965, J Laryngol Otol, V79, P1093, DOI 10.1017/S0022215100064860 HAZARIKA D, 1993, ACTA CYTOL, V37, P552 Kakar P K, 1966, J Laryngol Otol, V80, P1260, DOI 10.1017/S0022215100066652 Kaufman MR, 2001, OTOLARYNG HEAD NECK, V124, P702, DOI 10.1067/mhn.2001.115371 KNUDSON AG, 1966, CANCER, V19, P1032, DOI 10.1002/1097-0142(196607)19:7<1032::AID-CNCR2820190719>3.0.CO;2-7 Leonardis M, 2003, EUR J SURG ONCOL, V29, P929, DOI 10.1016/j.ejso.2003.08.010 Lewis D, 1930, ANN SURG, V92, P961, DOI 10.1097/00000658-193012000-00001 Lloyd RV, 1998, BRIT J PLAST SURG, V51, P135, DOI 10.1054/bjps.1997.0077 Muller A, 2002, ACTA OTO-LARYNGOL, V122, P565, DOI 10.1080/00016480260092426 PACK GT, 1953, AMA ARCH SURG, V67, P645 Ponce-Camacho MA, 2008, CYTOJOURNAL, V5, DOI 10.1186/1742-6413-5-5 Shimada H, 1999, CANCER, V86, P349, DOI 10.1002/(SICI)1097-0142(19990715)86:2<349::AID-CNCR20>3.0.CO;2-Y SHOTTON JC, 1992, J LARYNGOL OTOL, V106, P277, DOI 10.1017/S0022215100119267 SHUMACKER HB, 1939, SURGERY, V5, P572 Starek Ivo, 2004, International Journal of Pediatric Otorhinolaryngology, V68, P601, DOI 10.1016/j.ijporl.2003.12.007 STOUT AP, 1924, JAMA-J AM MED ASSOC, V82, P1770 TODD G B, 1973, Journal of Laryngology and Otology, V87, P979, DOI 10.1017/S0022215100077896 Weiss SW, 1994, HISTOLOGICAL TYPING WILLIAMS IG, 1965, P ROY SOC MED, V58, P609 NR 30 TC 2 Z9 2 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD DEC PY 2011 VL 120 IS 12 BP 769 EP 774 PG 6 WC Otorhinolaryngology SC Otorhinolaryngology GA 864WJ UT WOS:000298270900001 PM 22279947 ER PT J AU Orbelo, D Ekbom, DC Thompson, DM AF Orbelo, Diana Ekbom, Dale C. Thompson, Dana M. TI Dysphonia Associated With Lingual Thyroid Gland and Hypothyroidism: Improvement After Lingual Thyroidectomy SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article; Proceedings Paper CT Meeting of the American-Broncho-Esophagological-Association CY APR 27-28, 2011 CL Chicago, IL SP Amer Broncho Esophagol Assoc DE dysphonia; euthyroid state; hoarseness; hypothyroid state; lingual thyroid gland AB We present a unique and medically complex case of improved voice after lingual thyroidectomy. A 10-year-old boy with multifactorial dysphonia presented with bilateral vocal fold lesions and sulci in the context of hypothyroidism as a result of a congenital lingual thyroid gland. Despite hormone replacement, medical treatment for asthma, allergy, cough, and possible reflux, as well as voice therapy, the dysphonia persisted. Significant improvement in both subjective and objective voice measures was achieved after surgical removal of the lingual thyroid gland, which allowed for maintenance of a consistent euthyroid state. Lingual thyroidectomy is typically reserved for cases of bleeding and dysphagia. This case supports dysphonia as a possible additional indication for lingual thyroidectomy. C1 [Orbelo, Diana; Ekbom, Dale C.; Thompson, Dana M.] Mayo Clin, Div Voice Restorat Surg, Dept Otorhinolaryngol Head & Neck Surg, Rochester, MN USA. [Orbelo, Diana] Mayo Clin, Div Speech Language Pathol, Dept Neurol, Rochester, MN USA. [Thompson, Dana M.] Mayo Clin, Div Pediat Otolaryngol Head & Neck Surg, Mayo Eugenio Litta Childrens Hosp, Rochester, MN USA. Mayo Clin, Coll Med, Rochester, MN USA. RP Orbelo, D (reprint author), 200 1st St SW, Rochester, MN 55905 USA. CR ABBOTT KV, 2010, CLIN MANAGEMENT CHIL, P111 Batsakis JG, 1996, ANN OTO RHINOL LARYN, V105, P996 BAUGHMAN RA, 1972, ORAL SURG ORAL MED O, V34, P781, DOI 10.1016/0030-4220(72)90296-4 Belafsky Peter C, 2002, Ear Nose Throat J, V81, P10 De Bodt MS, 2007, J VOICE, V21, P151, DOI 10.1016/j.jvoice.2005.11.006 DOBRES R, 1990, J SPEECH HEAR DISORD, V55, P526 Kalan A., 1999, ENT-EAR NOSE THROAT, V78, P345 Kalan A, 1999, Ear Nose Throat J, V78, P340 Montgomery ML, 1936, WEST J SURG, V44, P189 Stoppa-Vaucher S, 2010, J CLIN ENDOCR METAB, V95, P4509, DOI 10.1210/jc.2010-0882 NR 10 TC 1 Z9 1 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD DEC PY 2011 VL 120 IS 12 BP 775 EP 779 PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA 864WJ UT WOS:000298270900002 PM 22279948 ER PT J AU Upton, DC Welham, NV Kuo, JS Walker, JW Pasic, TR AF Upton, David C. Welham, Nathan V. Kuo, John S. Walker, Jeffery W. Pasic, Thomas R. TI Chronic Rhinosinusitis With Nasal Polyps: A Proteomic Analysis SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article; Proceedings Paper CT Meeting of the Wisconsin-Society-of-Otolaryngology CY OCT 24-25, 2009 CL Madison, WI SP Wisconsin Soc Otolaryngol DE annexin A1; apolipoprotein A-1; chronic rhinosinusitis; eosinophil; nasal polyp; polyposis pathophysiology; proteomics ID EXPRESSION; EOSINOPHIL; LYSOPHOSPHOLIPASE; SINUSITIS; PROTEINS; LIPIDS; GENES; CELLS; FLUID AB Objectives: Chronic rhinosinusitis with nasal polyps (CRSwNP) is a severe subtype of chronic rhinosinusitis that can affect patients despite medical and surgical interventions. The purpose of this study was to utilize the techniques of proteomics to investigate differences in protein abundance within the sinonasal mucosa of patients with CRSwNP compared to healthy controls. Methods: In a case-control study at a tertiary-care academic medical center, sinonasal mucosa was harvested from 3 patients with CRSwNP and 3 control patients undergoing transsphenoidal excision of pituitary tumors. Two-dimensional gel electrophoresis was used to identify proteins with elevated or reduced abundance in CRSwNP patients compared to controls. The proteins showing the greatest abundance differences were characterized by mass spectrometry. Results: More than 300 differentially abundant proteins (p <= 0.05) were identified. Many of these protein species were involved in the host inflammatory response. Proteins up-regulated in CRSwNP patients included eosinophil lysophospholipase by a ratio (R) of 18.13, RHO-GDP dissociation inhibitor 2 (R = 2.80), and apolipoprotein A-1 (R = 1.73). Down-regulated proteins in CRSwNP patients included catalase (R = 5.87), annexin A1 (R = 6.27), and keratin II-8 (R = -6.73). A detailed analysis of additional protein species is outlined. Conclusions: The proteomic approach allows detection of significant differences in protein abundance in CRSwNP and provides unique insight into the pathophysiology of this common disease. C1 [Upton, David C.; Welham, Nathan V.; Pasic, Thomas R.] Univ Wisconsin Hosp & Clin, Dept Surg, Div Otolaryngol, Madison, WI 53792 USA. [Kuo, John S.] Univ Wisconsin Hosp & Clin, Dept Neurol Surg, Madison, WI 53792 USA. [Walker, Jeffery W.] Univ Arizona, Dept Physiol, Tucson, AZ USA. RP Pasic, TR (reprint author), Univ Wisconsin Hosp & Clin, Dept Surg, Div Otolaryngol, 600 Highland Ave, Madison, WI 53792 USA. RI Kuo, John/D-3561-2013 OI Kuo, John/0000-0001-6809-4806 CR ACKERMAN SJ, 1993, J IMMUNOL, V150, P456 Coulombe PA, 2002, CURR OPIN CELL BIOL, V14, P110, DOI 10.1016/S0955-0674(01)00301-5 Do TQ, 2008, J IMMUNOL, V181, P4177 Ghafouri B, 2002, PROTEOMICS, V2, P112, DOI 10.1002/1615-9861(200201)2:1<112::AID-PROT112>3.0.CO;2-N HARLIN SL, 1988, J ALLERGY CLIN IMMUN, V81, P867, DOI 10.1016/0091-6749(88)90944-X Lane AP, 2006, AM J RHINOL, V20, P138 Lanza DC, 1997, OTOLARYNG HEAD NECK, V117, pS1, DOI 10.1016/S0194-5998(97)70001-9 Liu Z, 2004, J ALLERGY CLIN IMMUN, V114, P783, DOI 10.1016/j.jaci.2004.04.052 Meltzer EO, 2004, OTOLARYNG HEAD NECK, V131, pS1, DOI 10.1016/j.otohns.2004.09.067 Richer SL, 2008, AM J RHINOL, V22, P228, DOI 10.2500/ajr.2008.22.3162 Rodrigo JP, 2004, ARCH OTOLARYNGOL, V130, P211, DOI 10.1001/archotol.130.2.211 Rosenfeld RM, 2007, OTOLARYNG HEAD NECK, V137, pS1, DOI 10.1016/j.otohns.2007.06.726 Saunders MW, 1999, LARYNGOSCOPE, V109, P785, DOI 10.1097/00005537-199905000-00019 Sena AAS, 2006, CLIN EXP ALLERGY, V36, P1260, DOI 10.1111/j.1365-2222.2006.02570.x Tewfik MA, 2007, AM J RHINOL, V21, P680, DOI 10.2500/ajr.2007.21.3103 Thormar H, 2007, CHEM PHYS LIPIDS, V150, P1, DOI 10.1016/j.chemphyslip.2007.06.220 WELLER PF, 1982, J IMMUNOL, V128, P1346 Wu Min-man, 2006, Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi, V41, P171 YOO JH, 1994, J CLIN INVEST, V93, P297, DOI 10.1172/JCI116959 Zaravinos A, 2008, CANCER LETT, V264, P288, DOI 10.1016/j.canlet.2008.01.046 NR 20 TC 3 Z9 3 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD DEC PY 2011 VL 120 IS 12 BP 780 EP 786 PG 7 WC Otorhinolaryngology SC Otorhinolaryngology GA 864WJ UT WOS:000298270900003 PM 22279949 ER PT J AU Sidell, D Mendelsohn, AH Shapiro, NL John, MS AF Sidell, Douglas Mendelsohn, Abie H. Shapiro, Nina L. John, Maie St. TI Management and Outcomes of Laryngeal Injuries in the Pediatric Population SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article; Proceedings Paper CT Meeting of the American-Broncho-Esophagological-Association CY APR 27-28, 2011 CL Chicago, IL SP Amer Broncho Esophagol Assoc DE larynx; pediatrics; trachea; trauma ID BLUNT LARYNGOTRACHEAL TRAUMA; NECK INJURIES; CHILDREN; PREVENTION; DISRUPTION; AIRWAY AB Objectives: Pediatric laryngeal trauma is an uncommon event. The purpose of this study was to identify outcomes following surgical procedures for pediatric laryngeal trauma, and to provide an in-depth review of the literature. Methods: The National Trauma Data Bank was utilized to identify pediatric laryngeal trauma incidents with admission years 2002 through 2006. Patient demographics, injury type, surgical procedures, hospital and intensive care unit durations, ventilator duration, and discharge disposition were abstracted. Results: There were 69 laryngeal trauma incidents identified, with a median patient age of 12.8 years and an overall mortality rate of 8.7%. Laryngeal injury was frequently blunt-force in nature (82.8%) and often occurred in con junction with trauma to multiple organ systems (76.8%). Tracheotomy (16 procedures), laryngeal suturing (13 procedures), and laryngeal fracture repair (10 procedures) were the most frequent procedures identified. Laryngeal fracture repair was noted to increase the overall hospital duration (p = 0.040). The communication scores were affected only by tracheotomy (p = 0.013). Surgical intervention did not significantly affect the frequency of home discharge. Conclusions: Pediatric laryngeal trauma is an uncommon event that can be evaluated with the National Trauma Data Bank. Although patients who undergo laryngeal fracture repair appear to have an increased duration of hospitalization, patients who undergo tracheotomy or laryngeal suturing do not have increased durations of ventilator dependence. stay in an intensive care unit, or hospitalization. C1 [Sidell, Douglas; Mendelsohn, Abie H.; Shapiro, Nina L.; John, Maie St.] Univ Calif Los Angeles, Div Head & Neck Surg, David Geffen Sch Med, Los Angeles, CA 90095 USA. RP Sidell, D (reprint author), Univ Calif Los Angeles, Div Head & Neck Surg, David Geffen Sch Med, 62-132 CHS,10833 Le Conte Ave, Los Angeles, CA 90095 USA. CR Abujamra L, 2003, PEDIATR EMERG CARE, V19, P308, DOI 10.1097/01.pec.0000092575.40174.f3 ALONSO WA, 1973, ANN OTO RHINOL LARYN, V82, P800 Bloom DC, 2001, INT J PEDIATR OTORHI, V60, P243, DOI 10.1016/S0165-5876(01)00533-X Cotton Bryan A, 2004, Semin Pediatr Surg, V13, P87, DOI 10.1053/j.sempedsurg.2004.01.004 Durkin MS, 1999, PEDIATRICS, V103, DOI 10.1542/peds.103.6.e74 Elmaraghy CA, 2007, ANN OTO RHINOL LARYN, V116, P192 FORD HR, 1995, J PEDIATR SURG, V30, P331, DOI 10.1016/0022-3468(95)90584-7 FUHRMAN GM, 1990, J TRAUMA, V30, P87, DOI 10.1097/00005373-199001000-00014 Gold SM, 1997, ARCH OTOLARYNGOL, V123, P83 Granger CV, 1998, ARCH PHYS MED REHAB, V79, P235, DOI 10.1016/S0003-9993(98)90000-4 GRATZ RR, 1979, J TRAUMA, V19, P551, DOI 10.1097/00005373-197908000-00001 Hilbe J. M., 2007, NEGATIVE BINOMIAL RE HUMAR A, 1991, Pediatric Emergency Care, V7, P291, DOI 10.1097/00006565-199110000-00008 Jewett BS, 1999, ARCH OTOLARYNGOL, V125, P877 Kim MK, 2000, OTOLARYNG HEAD NECK, V123, P439, DOI 10.1067/mhn.2000.109760 Kurien M, 1999, INT J PEDIATR OTORHI, V49, P115, DOI 10.1016/S0165-5876(99)00109-3 Lichenstein R, 2002, J EMERG MED, V22, P375, DOI 10.1016/S0736-4679(02)00439-0 Losek JD, 2008, PEDIATR EMERG CARE, V24, P370, DOI 10.1097/PEC.0b013e318177a78a MACE SE, 1986, ANN EMERG MED, V15, P836, DOI 10.1016/S0196-0644(86)80387-0 MATHISEN DJ, 1987, ANN THORAC SURG, V43, P254 MCLAUGHLIN J, 1986, ANN EMERG MED, V15, P463, DOI 10.1016/S0196-0644(86)80189-5 MYER CM, 1987, LARYNGOSCOPE, V97, P1043 Nance ML, 2003, J TRAUMA, V55, P631, DOI 10.1097/01.TA.0000035090.99483.0A Quesnel AM, 2009, LARYNGOSCOPE, V119, P2226, DOI 10.1002/lary.20492 Rogers SC, 2010, J TRAUMA, V69, pS209, DOI 10.1097/TA.0b013e3181f1e9fe SCHAEFER SD, 1982, ANN OTO RHINOL LARYN, V91, P399 SCHAEFER SD, 1983, LARYNGOSCOPE, V93, P1473 SCHAEFER SD, 1991, ARCH OTOLARYNGOL, V117, P35 SEMMLOW JL, 1976, HEALTH SERV RES, V11, P45 Shires CB, 2011, INT J PEDIATR OTORHI, V75, P401, DOI 10.1016/j.ijporl.2010.12.016 Smith DF, 2009, INT J PEDIATR OTORHI, V73, P1817, DOI 10.1016/j.ijporl.2009.08.022 Wootten CT, 2009, INT J PEDIATR OTORHI, V73, P1071, DOI 10.1016/j.ijporl.2009.02.025 NR 32 TC 2 Z9 2 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD DEC PY 2011 VL 120 IS 12 BP 787 EP 795 PG 9 WC Otorhinolaryngology SC Otorhinolaryngology GA 864WJ UT WOS:000298270900004 PM 22279950 ER PT J AU Bock, JM Van Daele, DJ Gupta, N Blumin, JH AF Bock, Jonathan M. Van Daele, Douglas J. Gupta, Nidhi Blumin, Joel H. TI Management of Zenker's Diverticulum in the Endoscopic Age: Current Practice Patterns SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article; Proceedings Paper CT Meeting of the American-Broncho-Esophagological-Association CY APR 27-28, 2011 CL Chicago, IL SP Amer Broncho Esophagol Assoc DE complication; dysphagia; endoscopy; laser; management; mediastinitis; stapler; surgery; Zenker's diverticulum ID CARBON-DIOXIDE LASER; STAPLING TECHNIQUE; OPERATION; THERAPY; FAILURE; MYOTOMY; REFLUX AB Objectives: Zenker's diverticulum (ZD) is a common source of dysphagia with a well-established surgical treatment history. Variations may exist between practitioners in the preoperative, intraoperative, and postoperative management of patients with ZD because of recent evolutions in surgical approach toward an endoscopic technique. Methods: An online survey instrument was prepared and forwarded to the membership of the American Broncho-Esophagological Association (ABEA) to ascertain the current practice patterns of its members regarding numerous care parameters for patients with ZD. Results: Data on preoperative evaluation, operative care, postoperative management, and recalled incidence of complications, including mediastinitis, were evaluated. Subgroup analysis demonstrated significant differences in multiple care parameters for those surgeons who predominantly perform endoscopic operations (more than 80% willingness to perform endoscopic operations) compared to those who occasionally perform endoscopic operations (less than 80%), including average case number, advancement of oral intake, hospital discharge, use of antibiotics, and views on the efficacy of endoscopic surgical techniques. These changes were noted despite similar times since graduation from training for the two groups. Conclusions: These data present a contemporary snapshot of clinical care patterns of the ABEA membership for patients with ZD and suggest differences in care patterns for surgeons with a higher enthusiasm for endoscopic techniques and larger case volumes. C1 [Bock, Jonathan M.; Gupta, Nidhi; Blumin, Joel H.] Med Coll Wisconsin, Dept Otolaryngol & Commun Sci, Div Laryngol & Profess Voice, Milwaukee, WI 53226 USA. [Van Daele, Douglas J.] Univ Iowa Hosp & Clin, Dept Otolaryngol Head & Neck Surg, Iowa City, IA 52242 USA. RP Bock, JM (reprint author), 9200 W Wisconsin Ave, Milwaukee, WI 53226 USA. CR Achkar E, 1998, DIGEST DIS, V16, P144, DOI 10.1159/000016858 Brace M, 2010, J OTOLARYNGOL-HEAD N, V39, P102, DOI 10.2310/7070.2009.080240 Chang CWD, 2004, LARYNGOSCOPE, V114, P519, DOI 10.1097/00005537-200403000-00025 COLLARD JM, 1993, ANN THORAC SURG, V56, P573 Counter PR, 2002, ANN ROY COLL SURG, V84, P89 Crescenzo DG, 1998, ANN THORAC SURG, V66, P347, DOI 10.1016/S0003-4975(98)00502-5 DOHLMAN G, 1960, ARCHIV OTOLARYNGOL, V71, P744 FEUSSNER H, 1992, HEPATO-GASTROENTEROL, V39, P100 Gross ND, 2004, LARYNGOSCOPE, V114, P208, DOI 10.1097/00005537-200402000-00006 Gutschow CA, 2002, ANN THORAC SURG, V74, P1677, DOI 10.1016/S0003-4975(02)03931-0 Hadley JM, 1997, CLIN RADIOL, V52, P613, DOI 10.1016/S0009-9260(97)80254-1 Haubrich WS, 2004, GASTROENTEROLOGY, V126, P1269, DOI 10.1053/j.gastro.2004.03.028 Helmstaedter V, 2009, ORL J OTO-RHINO-LARY, V71, P40, DOI 10.1159/000170379 Hillel AT, 2009, LARYNGOSCOPE, V119, P39, DOI 10.1002/lary.20019 Hoffman M, 2003, ANN OTO RHINOL LARYN, V112, P202 Miller FR, 2006, LARYNGOSCOPE, V116, P1608, DOI 10.1097/01.mlg.0000233508.06499.41 Munoz AA, 2007, ANN OTO RHINOL LARYN, V116, P49 Rizzetto C, 2008, J GASTROINTEST SURG, V12, P2057, DOI 10.1007/s11605-008-0684-7 Sasaki CT, 2003, AM J MED, V115, p169S, DOI 10.1016/S0002-9343(03)00218-3 SCHUCHERT MJ, 2005, GEN THORACIC SURG, V2, P2050 Siddiq MA, 2004, ANN ROY COLL SURG, V86, P247, DOI 10.1308/147870804524 Smith SR, 2002, ARCH OTOLARYNGOL, V128, P141 Tokashiki R, 2010, EUR ARCH OTO-RHINO-L, V267, P737, DOI 10.1007/s00405-009-1134-1 Vaiman M, 2006, DYSPHAGIA, V21, P14, DOI 10.1007/s00455-005-9006-3 Van Daele DJ, 2005, ANN OTO RHINOL LARYN, V114, P946 Visosky AMB, 2008, ANN OTO RHINOL LARYN, V117, P531 Westrin KM, 1996, ACTA OTO-LARYNGOL, V116, P351, DOI 10.3109/00016489609137857 WOUTERS B, 1992, HEPATO-GASTROENTEROL, V39, P105 NR 28 TC 4 Z9 4 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD DEC PY 2011 VL 120 IS 12 BP 796 EP 806 PG 11 WC Otorhinolaryngology SC Otorhinolaryngology GA 864WJ UT WOS:000298270900005 PM 22279951 ER PT J AU Timmer, FCA Artz, JCJM Beynon, AJ Donders, RT Mulder, JJS Cremers, CWRJ Graamans, K AF Timmer, Ferdinand C. A. Artz, Janneke C. J. M. Beynon, Andy J. Donders, Rogier T. Mulder, Jef J. S. Cremers, Cor W. R. J. Graamans, Kees TI Prediction of Vestibular Schwannoma Growth: A Novel Rule Based on Clinical Symptomatology SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE acoustic neuroma; audiometry; diagnostic rule; growth; predictor of growth; symptom; vestibular schwannoma ID CONSERVATIVE MANAGEMENT; ACOUSTIC NEUROMAS; HISTORY AB Objectives: The aim of this study was to formulate a predictive rule for vestibular schwannoma growth during the initial observation period after diagnosis. Methods: Logistic regression models were fitted, with tumor growth in the first year as the dependent variable and patient characteristics as the independent variables. Backward selection was used to eliminate superfluous predictors. The area under the receiver operating characteristic curve was taken as a measure of the model's discriminative power. Results: Eventually, the model or rule consisted of 4 significant growth predictors: localization (if extrameatal, +1; if intrameatal, 0), sudden sensorineural hearing loss (if present, 1; if absent, 0), balance symptoms (if present, +1; if absent, 0), and complaints of hearing loss for less than 2 years (if present, +1; if absent, or present for more than 2 years, 0). A higher score indicates a higher likelihood of tumor growth during the period of observation after diagnosis. If the total score is 0 or less, the likelihood of tumor growth during the first year after diagnosis is less than 10%. If the score is 3, the likelihood of growth during the first year after diagnosis is more than 70%. Conclusions: We were able to create a useful rule to predict vestibular schwannoma growth during the first year after diagnosis. C1 [Timmer, Ferdinand C. A.; Artz, Janneke C. J. M.; Beynon, Andy J.; Mulder, Jef J. S.; Cremers, Cor W. R. J.; Graamans, Kees] Radboud Univ Nijmegen, Med Ctr, Dept Otorhinolaryngol Head & Neck Surg, Donders Inst Brain Cognit & Behav, NL-6500 HB Nijmegen, Netherlands. [Donders, Rogier T.] Radboud Univ Nijmegen, Med Ctr, Dept Epidemiol Biostat & Hlth Technol Assessment, NL-6500 HB Nijmegen, Netherlands. RP Timmer, FCA (reprint author), Radboud Univ Nijmegen, Med Ctr, Dept Otorhinolaryngol Head & Neck Surg, Donders Inst Brain Cognit & Behav, POB 9101, NL-6500 HB Nijmegen, Netherlands. CR APGAR V, 1953, Curr Res Anesth Analg, V32, P260 Artz JCJM, 2009, EUR ARCH OTO-RHINO-L, V266, P641, DOI 10.1007/s00405-008-0791-9 Battaglia A, 2006, OTOL NEUROTOL, V27, P705, DOI 10.1097/01.mao.0000226302.59198.87 Charabi S, 2000, LARYNGOSCOPE, V110, P1720, DOI 10.1097/00005537-200010000-00030 Charabi S, 1999, Ugeskr Laeger, V161, P2673 Hajioff D, 2008, CLIN OTOLARYNGOL, V33, P255, DOI 10.1111/j.1749-4486.2008.01705.x HUYGEN PLM, 1985, ORL J OTO-RHINO-LARY, V47, P249 JERGER J, 1971, ARCHIV OTOLARYNGOL, V93, P573 Lin Doris, 2005, Arch Otolaryngol Head Neck Surg, V131, P241, DOI 10.1001/archotol.131.3.241 METZ CE, 1978, SEMIN NUCL MED, V8, P283, DOI 10.1016/S0001-2998(78)80014-2 Mirz F, 2000, ACTA OTO-LARYNGOL, P30 NIJHUIS BG, 1980, ORL J OTO-RHINO-LARY, V42, P196 Nikolopoulos TP, 2010, OTOL NEUROTOL, V31, P478, DOI 10.1097/MAO.0b013e3181d279a3 ROSENBERG SI, 1993, OTOLARYNG HEAD NECK, V109, P482 SILVERSTEIN H, 1985, LARYNGOSCOPE, V95, P766 Stangerup SE, 2006, OTOL NEUROTOL, V27, P547, DOI 10.1097/00129492-200606000-00018 THEUNISSEN EJJM, 1986, CLIN OTOLARYNGOL, V11, P161, DOI 10.1111/j.1365-2273.1986.tb00123.x VONGIERKE H, 1992, AVIAT SPACE ENVIR S, V63, P1 NR 18 TC 0 Z9 0 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD DEC PY 2011 VL 120 IS 12 BP 807 EP 813 PG 7 WC Otorhinolaryngology SC Otorhinolaryngology GA 864WJ UT WOS:000298270900006 PM 22279952 ER PT J AU van der Houwen, EB van Kalkeren, TA Burgerhof, JGM van der Laan, BFAM Verkerke, GJ AF van der Houwen, Eduard B. van Kalkeren, Tjouwke A. Burgerhof, Johannes G. M. van der Laan, Bernard F. A. M. Verkerke, Gijsbertus J. TI In Vitro Evaluation of the iValve: A Novel Hands-Free Speech Valve SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article; Proceedings Paper CT 3rd Dutch Biomedical Engineering Conference CY JAN 20, 2011 CL Egmond aan Zee, NETHERLANDS DE automatic speech valve; hands-free speech; inhalation valve; laryngectomy; tracheostoma; voice rehabilitation ID IMPROVED TRACHEOSTOMA VALVE; PEAK INSPIRATORY FLOW; PROVOX FREEHANDS HME; AERODYNAMIC CHARACTERISTICS; VOICE REHABILITATION; LARYNGECTOMY; RESISTANCE; INHALATION; HEAT AB Objectives: We performed in vitro evaluation of a novel, disposable, automatic hands-free tracheostoma speech valve for laryngectomy patients based upon the principle of inhalation. The commercially available automatic speech valves close upon strong exhalation and open again when the pressure drops. This method makes long sentences or pauses difficult. The novel iValve is designed to allow almost natural speech, with mid-sentence pausing and whispering. Methods: The inhalation closing flows and exhalation opening pressures of 6 iValve prototype versions at different settings were compared with physiological values. The airflow resistance at inhalation was compared to physiological values and to commercial valve values. Results: The iValve prototypes showed flow and pressure ranges in concordance with the physiological values in the literature. The airflow resistance in the breathing mode was within the physiological airflow resistance range, yet above the values from the two commercial valves. The resistance in the speaking mode was above the physiological airflow resistance range. Conclusions: In vitro tests show that the iValve versions can be selected and adjusted to operate within the physiological range. The airflow resistance in the breathing mode is good. In speaking mode, inhalation should, and can, be decreased. The iValve should offer the patient a more intuitively useable alternative with more dynamic speech. Its low cost allows disposability and wider use. C1 [van der Houwen, Eduard B.; Verkerke, Gijsbertus J.] Univ Groningen, Dept Biomed Engn, Univ Med Ctr Groningen, NL-9713 AV Groningen, Netherlands. [van Kalkeren, Tjouwke A.; van der Laan, Bernard F. A. M.] Univ Groningen, Dept Otorhinolaryngol Head & Neck Surg, Univ Med Ctr Groningen, NL-9713 AV Groningen, Netherlands. [Burgerhof, Johannes G. M.] Univ Groningen, Dept Epidemiol, Univ Med Ctr Groningen, NL-9713 AV Groningen, Netherlands. [Verkerke, Gijsbertus J.] Univ Twente, Fac Engn Technol, Twente, Netherlands. RP van der Houwen, EB (reprint author), Univ Groningen, Dept Biomed Engn, Univ Med Ctr Groningen, A Deusinglaan 1, NL-9713 AV Groningen, Netherlands. RI Burgerhof, Johannes/B-2455-2013; van der Laan, Bernard/H-2420-2011 OI Burgerhof, Johannes/0000-0003-3827-9601; van der Laan, Bernard/0000-0002-5016-2871 CR BROWN PH, 1995, EUR RESPIR J, V8, P1940, DOI 10.1183/09031936.95.08111940 DEPLEDGE MH, 1985, THORAX, V40, P205, DOI 10.1136/thx.40.3.205 DRAKELEE A, 1997, BASIC SCI SCOTTBROWN, P1 Geertsema AA, 2002, ANN OTO RHINOL LARYN, V111, P142 Geertsema AA, 1998, EUR ARCH OTO-RHINO-L, V255, P244, DOI 10.1007/s004050050051 Geertsema AA, 1999, ARCH OTOLARYNGOL, V125, P622 GROLMAN W, 2006, ORL J OTORHINOLARYNG, V69, P68 Hamadé Rachel, 2006, Clin Linguist Phon, V20, P187, DOI 10.1080/02699200400026959 Hilgers FJM, 2003, ACTA OTO-LARYNGOL, V123, P91, DOI 10.1080/0036554021000028083 Liu HJ, 2004, J VOICE, V18, P567, DOI 10.1016/j.jvoice.2003.12.011 Lorenz KJ, 2007, EUR ARCH OTO-RHINO-L, V264, P151, DOI 10.1007/s00405-006-0155-2 Op de Coul BMR, 2005, ACTA OTO-LARYNGOL, V125, P629, DOI 10.1080/00016480510031515 Roxburgh J, 2004, ANN OTO RHINOL LARYN, V113, P565 Ten Hallers EJO, 2005, ACTA OTO-LARYNGOL, V125, P804, DOI 10.1080/00016480510031506 vandenHoogen FJA, 1996, EUR ARCH OTO-RHINO-L, V253, P126 Verkerke GJ, 2002, ANN OTO RHINOL LARYN, V111, P333 Verkerke GJ, 2001, ANN OTO RHINOL LARYN, V110, P639 NR 17 TC 2 Z9 2 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD DEC PY 2011 VL 120 IS 12 BP 814 EP 819 PG 6 WC Otorhinolaryngology SC Otorhinolaryngology GA 864WJ UT WOS:000298270900007 PM 22279953 ER PT J AU Shen, B Li, DW Dong, P Gao, S AF Shen, Bin Li, Dawei Dong, Pin Gao, Shang TI Expression of ABC Transporters Is an Unfavorable Prognostic Factor in Laryngeal Squamous Cell Carcinoma SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE apoptosis; breast cancer resistance protein; cell proliferation; laryngeal squamous cell carcinoma; P-glycoprotein; prognosis ID CANCER RESISTANCE PROTEIN; ACUTE LYMPHOBLASTIC-LEUKEMIA; BREAST-CANCER; MULTIDRUG-RESISTANCE; P-GLYCOPROTEIN; HEPATOCELLULAR-CARCINOMA; SIDE POPULATION; APOPTOSIS; BCRP; PROLIFERATION AB Objectives: Two prominent and well-characterized representatives of adenosine triphosphate binding cassette (ABC) transporter breast cancer resistance protein (BCRP or A BCG2) and P-glycoprotein (P-gp or ABCB1) are known to be membrane transporters associated with multidrug resistance. The aim of this study was to explore the correlation between ABC transporter expression and the clinicopathologic characteristics, proliferative index, and apoptotic index and their prognostic value in laryngeal squamous cell carcinoma (LSCC). Methods: Paraffin sections of 98 human LSCC specimens were investigated with immunohistochemical techniques. The relationship between ABCG2 and ABCB1 expression and clinicopathologic parameters, proliferative activities, and apoptotic activities and their prognostic value in patients' overall survival rate were subsequently analyzed. Results: Immunohistochemical analysis revealed positive expression of ABCG2 and ABCB1 in 52.0% and 41.8% of patients, respectively. There was a positive correlation between ABCG2 expression and ABCB1 expression. The presence of these two proteins was significantly related to clinical stage, lymph node metastasis, and overall survival in LSCC. Interestingly, up-regulation of ABCG2 expression was found to be associated with increased proliferation, but that of ABCB1 was not. Up-regulation of both ABCG2 expression and ABCB1 expression was associated with decreased apoptosis. Conclusions: The results of this study revealed that the presence of ABCG2 and/or ABCB1 is predictive for malignant progression and is an independent prognostic factor in LSCC. The mechanism of ABC transporters may contribute to chemotherapy resistance by promoting proliferation and/or suppressing apoptosis. C1 [Shen, Bin; Li, Dawei; Dong, Pin; Gao, Shang] Shanghai Jiao Tong Univ, Dept Otolaryngol Head & Neck Surg, Affiliated Peoples Hosp 1, Shanghai 200030, Peoples R China. RP Dong, P (reprint author), Shanghai Jiao Tong Univ, Dept Otolaryngol Head & Neck Surg, Affiliated Peoples Hosp 1, Shanghai 200030, Peoples R China. FU Shanghai Science and Technology Development Fund, China [09411 951000]; Resource Sharing Platform for Clinical Research, China [SHDC12007206] FX This study was supported by the Shanghai Science and Technology Development Fund (No. 09411 951000), China, and the Resource Sharing Platform for Clinical Research (No. SHDC12007206), China. CR Abbott BL, 2002, BLOOD, V100, P4594, DOI 10.1182/blood-2002-01-0271 ALVAREZ M, 1995, J CLIN INVEST, V95, P2205, DOI 10.1172/JCI117910 Benderra Z, 2004, CLIN CANCER RES, V10, P7896, DOI 10.1158/1078-0432.CCR-04-0795 Borst P, 2002, ANNU REV BIOCHEM, V71, P537, DOI 10.1146/annurev.biochem.71.102301.093055 Chu EA, 2008, OTOLARYNG CLIN N AM, V41, P673, DOI 10.1016/j.otc.2008.01.016 Chu EA, 2008, OTOLARYNGOL CLIN N A, V41, pv Dean M, 2001, J LIPID RES, V42, P1007 Diestra JE, 2002, J PATHOL, V198, P213, DOI 10.1002/path.1203 Doyle LA, 1999, P NATL ACAD SCI USA, V96, P2569 Doyle LA, 1998, P NATL ACAD SCI USA, V95, P15665, DOI 10.1073/pnas.95.26.15665 Eckford PDW, 2009, CHEM REV, V109, P2989, DOI 10.1021/cr9000226 Faneyte IF, 2002, CLIN CANCER RES, V8, P1068 Gottesman MM, 2002, NAT REV CANCER, V2, P48, DOI 10.1038/nrc706 Gottesman Michael M, 2006, Discov Med, V6, P18 Hipfner DR, 2004, NAT REV MOL CELL BIO, V5, P805, DOI 10.1038/nrm1491 LI DW, MED ONCOL IN PRESS Li L, 2007, OTOLARYNG HEAD NECK, V137, P659, DOI 10.1016/j.otohns.2007.04.026 Li L, 2009, ANN SURG ONCOL, V16, P1421, DOI 10.1245/s10434-009-0395-7 Mizutani T, 2008, CURR DRUG METAB, V9, P167, DOI 10.2174/138920008783571756 Nakayama K, 2002, INT J CANCER, V101, P488, DOI 10.1002/ijc.10608 Pai SI, 2009, ANNU REV PATHOL-MECH, V4, P49, DOI 10.1146/annurev.pathol.4.110807.092158 Penson RT, 2004, GYNECOL ONCOL, V93, P98, DOI 10.1016/j.ygyno.2003.11.053 Plasschaert SLA, 2003, CLIN CANCER RES, V9, P5171 Rocchi E, 2000, BIOCHEM BIOPH RES CO, V271, P42, DOI 10.1006/bbrc.2000.2590 Sauerbrey A, 2002, BRIT J HAEMATOL, V118, P147, DOI 10.1046/j.1365-2141.2002.03550.x Shi GM, 2008, J CANCER RES CLIN, V134, P1155, DOI 10.1007/s00432-008-0407-1 Smyth MJ, 1998, P NATL ACAD SCI USA, V95, P7024, DOI 10.1073/pnas.95.12.7024 Steinbach D, 2002, LEUKEMIA, V16, P1443, DOI 10.1038/sj.leu.2402541 Takanishi K, 1997, ONCOLOGY, V54, P231 Teppo H, 2003, APMIS, V111, P451, DOI 10.1034/j.1600-0463.2003.1110401.x Tsunoda S, 2006, ONCOLOGY-BASEL, V71, P251, DOI 10.1159/000106787 Wang YH, 2009, NEOPLASMA, V56, P371, DOI 10.4149/neo_2009_05_371 Yoh K, 2004, CLIN CANCER RES, V10, P1691, DOI 10.1158/1078-0432.CCR-0937-3 NR 33 TC 6 Z9 6 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD DEC PY 2011 VL 120 IS 12 BP 820 EP 827 PG 8 WC Otorhinolaryngology SC Otorhinolaryngology GA 864WJ UT WOS:000298270900008 PM 22279954 ER PT J AU Pawar, SS Chun, RH Rao, AR Kerschner, JE AF Pawar, Sachin S. Chun, Robert H. Rao, Aparna R. Kerschner, Joseph E. TI Management of Plastic Bronchitis in a Child With Mild Intermittent Asthma SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article; Proceedings Paper CT Meeting of the American-Broncho-Esophagological-Association CY APR 27-28, 2011 CL Chicago, IL SP Amer Broncho Esophagol Assoc DE asthma; bronchitis; endoscopy ID OF-THE-LITERATURE; CHALLENGE AB Objectives: We describe the clinical presentation of a 71/2-year-old boy with a history of mild intermittent asthma who presented with left lung collapse and was found to have plastic bronchitis. Methods: We reviewed the patient chart and imaging results and performed a literature review of plastic bronchitis and its management. Results: Bronchoscopy in our patient demonstrated a large white, friable, cast-like material that obstructed the entire left main stem bronchus and could not be easily suctioned. The cast was removed in a piecemeal fashion by means of serial rigid bronchoscopy over a 6-month period with use of both optical forceps and flexible suction catheters. Microscopic examination of the cast-like material showed a predominance of eosinophils along with neutrophils encased in proteinaceous material. Conclusions: Plastic bronchitis in children is a rare condition that can mimic foreign body aspiration and can be associated with underlying pulmonary inflammatory disorders or cardiovascular disease. Aggressive bronchoscopic management of the airway obstruction and medical management of the underlying disease process are important for the successful treatment of plastic bronchitis. C1 [Pawar, Sachin S.; Chun, Robert H.; Kerschner, Joseph E.] Med Coll Wisconsin, Dept Otolaryngol & Commun Sci, Milwaukee, WI 53226 USA. [Rao, Aparna R.] Med Coll Wisconsin, Dept Pediat, Milwaukee, WI 53226 USA. RP Chun, RH (reprint author), Med Coll Wisconsin, Dept Otolaryngol, 9000 W Wisconsin Ave,POB 1997,Suite 350, Milwaukee, WI 53226 USA. EM rchun@mcw.edu CR Brogan TV, 2002, PEDIATR PULM, V34, P482, DOI 10.1002/ppul.10179 Do TB, 2009, PEDIATR CARDIOL, V30, P352, DOI 10.1007/s00246-008-9312-2 Eberlein MH, 2008, AM J MED SCI, V335, P163, DOI 10.1097/MAJ.0b013e318068b60e Ishman S, 2003, INT J PEDIATR OTORHI, V67, P543, DOI 10.1016/S0165-5876(03)00004-1 Nayar S, 2007, ANN THORAC SURG, V83, P1884, DOI 10.1016/j.athoracsur.2006.12.027 Preciado D, 2010, INT J PEDIATR OTORHI, V74, P820, DOI 10.1016/j.ijporl.2010.02.005 Schultz KD, 2003, PEDIATR PULM, V35, P139, DOI 10.1002/ppul.10196 Seear M, 1997, AM J RESP CRIT CARE, V155, P364 Salman S, 2006, ANN THORAC SURG, V81, P2281, DOI 10.1016/j.athoracsur.2005.07.004 NR 9 TC 2 Z9 4 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD NOV PY 2011 VL 120 IS 11 BP 697 EP 699 PG 3 WC Otorhinolaryngology SC Otorhinolaryngology GA 852SN UT WOS:000297377900001 PM 22224309 ER PT J AU Brook, I Hausfeld, JN AF Brook, Itzhak Hausfeld, Jeffrey N. TI Microbiology of Acute and Chronic Maxillary Sinusitis in Smokers and Nonsmokers SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE beta-lactamase; methicill in resistance; sinusitis; smoking; Staphylococcus aureus ID RESISTANT STAPHYLOCOCCUS-AUREUS; ANTIMICROBIAL THERAPY; SMOKING; RHINOSINUSITIS; BACTERIOLOGY; POPULATION; INFECTIONS; PATHOGENS; ADHERENCE; RECOVERY AB Objectives: We evaluated the microbiology of sinus aspirates of smokers and nonsmokers with acute and chronic maxillary sinusitis. Methods: Cultures were obtained from 458 patients, 244 (87 smokers and 157 nonsmokers) of whom had acute maxillary sinusitis and 214 (84 smokers and 130 nonsmokers) of whom had chronic maxillary sinusitis, between 2001 and 2007. Results: A greater number of Staphylococcus aureus, methicillin-resistant S aureus (MRSA), and beta-lactamase producing bacteria (BLPB) were found in the 87 smokers with acute sinusitis than in the nonsmokers with acute sinusitis (p <0.005, p <0.025, and p <0.05, respectively). A greater number of these organisms were found in the 84 smokers with chronic sinusitis than in the nonsmokers (p < 0.01, p < 0.025, and p < 0.001, respectively). Eighty-five BLPB isolates were recovered from 73 patients (30%) with acute sinusitis. These included Moraxella catarrhalis, S aureus, Haemophilus influenzae, Prevotella spp, and Fusobacterium spp; 40 BLPB isolates were found in smokers, and 45 in nonsmokers (p <0.05). One hundred twenty-five BLPB isolates were recovered from 91 patients (43%) with chronic sinusitis, including M catarrhalis, Bacteroides fragilis group, S aureus, influenzae, Prevotella spp, and Fusobacterium spp; 69 BLPB isolates were found in smokers, and 56 in nonsmokers (p <0.001). Antimicrobial therapy had been administered in the past month to 130 patients (28%; 60 smokers and 70 nonsmokers; p <0.025). Both MRSA and BLPB were isolated more often from these individuals (p <0.025). However, the higher isolation rates of MRSA and BLPB in smokers were independent of previous antimicrobial therapy. Conclusions: These data illustrate a greater frequency of isolation of S aureus, MRSA, and BLPB in patients with acute and chronic sinusitis who smoke. C1 [Brook, Itzhak; Hausfeld, Jeffrey N.] Georgetown Univ, Sch Med, Dept Pediat, Washington, DC 20007 USA. RP Brook, I (reprint author), 4431 Albemarle St NW, Washington, DC 20016 USA. CR Anon JB, 2004, OTOLARYNG HEAD NECK, V130, P794 BAGAITKAR J, 2008, TOB INDUC DIS, V18, P12 Baron E. J., 2003, MANUAL CLIN MICROBIO, V8th Benninger MS, 2006, OTOLARYNG HEAD NECK, V134, P3, DOI 10.1016/j.otohns.2005.10.010 BLACKWELL CC, 1990, EPIDEMIOL INFECT, V104, P203 Boyce JM, 2002, INFECT CONT HOSP EP, V23, P485, DOI 10.1086/502092 Brook I, 2007, ARCH OTOLARYNGOL, V133, P135, DOI 10.1001/archotol.133.2.135 Brook I, 2009, J LARYNGOL OTOL, V123, P1301, DOI 10.1017/S0022215109990624 Brook I, 2005, CHEST, V127, P2072, DOI 10.1378/chest.127.6.2072 Brook I, 1996, ARCH OTOLARYNGOL, V122, P418 BROOK I, 1988, LARYNGOSCOPE, V98, P428 Brook I, 2006, ARCH OTOLARYNGOL, V132, P1099, DOI 10.1001/archotol.132.10.1099 Brook I, 1999, ANN OTO RHINOL LARYN, V108, P645 Brook I, 2008, J MED MICROBIOL, V57, P1015, DOI 10.1099/jmm.0.2008/000851-0 Brook I, 2006, INT J PEDIATR OTORHI, V70, P2099, DOI 10.1016/j.ijporl.2006.08.004 Brook I, 1996, J MED MICROBIOL, V45, P372 Carrasco-Garrido P, 2008, PHARMACOEPIDEM DR S, V17, P193, DOI 10.1002/pds.1455 Choi Chong Seng, 2006, Journal of Microbiology Immunology and Infection, V39, P458 El Ahmer OR, 1999, FEMS IMMUNOL MED MIC, V23, P27, DOI 10.1016/S0928-8244(98)00114-X FAINSTEIN V, 1979, INFECT IMMUN, V26, P178 Fujimori I, 1995, Kansenshogaku Zasshi, V69, P133 Gerencer RZ, 2005, OTOLARYNG HEAD NECK, V132, P828, DOI 10.1016/j.otohns.2005.03.003 GRYCZYNSKA D, 1999, J PEDIAT OTORHINO S1, V49, pS275 GWALTNEY JM, 1992, J ALLERGY CLIN IMMUN, V90, P457, DOI 10.1016/0091-6749(92)90169-3 Howden BP, 2006, ANTIMICROB AGENTS CH, V50, P3039, DOI 10.1128/AAC.00422-06 Kuehnert MJ, 2006, J INFECT DIS, V193, P172, DOI 10.1086/499632 *NCCL, 2003, M28 NCCL OCALLAGHAN DH, 1972, ANTIMICROB AGENTS CH, V1, P283 Palmer RM, 2005, J CLIN PERIODONTOL, V32, P180, DOI 10.1111/j.1600-051X.2005.00786.x Reh DD, 2009, AMJ RHINOL ALLERGY, V23, P562, DOI 10.2500/ajra.2009.23.3377 Schneider-Lindner V, 2007, EMERG INFECT DIS, V13, P994, DOI 10.3201/eid1307.061561 NR 31 TC 6 Z9 6 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD NOV PY 2011 VL 120 IS 11 BP 707 EP 712 PG 6 WC Otorhinolaryngology SC Otorhinolaryngology GA 852SN UT WOS:000297377900003 PM 22224311 ER PT J AU Saito, T Ito, T Narita, N Yamada, T Manabe, Y AF Saito, Takehisa Ito, Tetsufumi Narita, Norihiko Yamada, Takechiyo Manabe, Yasuhiro TI Light and Electron Microscopic Observation of Regenerated Fungiform Taste Buds in Patients With Recovered Taste Function After Severing Chorda Tympani Nerve SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE chorda tympani nerve; fungiform papilla; immunohistochemical staining; regeneration; taste bud; transmission electron microscopy ID MIDDLE-EAR SURGERY; PAPILLAE; NUMBER; DAMAGE; MORPHOLOGY; INJURY; REPAIR; CELL AB Objectives: The aim of this study was to evaluate the mean number of regenerated fungiform taste buds per papilla and perform light and electron microscopic observation of taste buds in patients with recovered taste function after severing the chorda tympani nerve during middle ear surgery. Methods: We performed a biopsy on the fungiform papillae (FP) in the midlateral region of the dorsal surface of the tongue from 5 control volunteers (33 total FP) and from 7 and 5 patients with and without taste recovery (34 and 29 FP, respectively) 3 years 6 months to 18 years after surgery. The specimens were observed by light and transmission electron microscopy. The taste function was evaluated by electrogustometry. Results:: The mean number of taste buds in the FP of patients with completely recovered taste function was significantly smaller (1.9 +/- 1.4 per papilla; p < 0.01) than that of the control subjects (3.8 +/- 2.2 per papilla). By transmission electron microscopy, 4 distinct types of cell (type 1, II, 111, and basal cells) were. identified in the regenerated taste buds. Nerve fibers and nerve terminals were also found in the taste buds. Conclusions: It was clarified that taste buds containing taste cells and nerve endings do regenerate in the FP of patients with recovered taste function. C1 [Saito, Takehisa; Narita, Norihiko; Yamada, Takechiyo] Univ Fukui, Dept Otolaryngol Head & Neck Surg, Eiheiji, Fukui 9101193, Japan. [Ito, Tetsufumi] Univ Fukui, Dept Anat, Fac Med, Fukui 9101193, Japan. [Saito, Takehisa] Univ Fukui, Res & Educ Program Life Sci, Fukui 9101193, Japan. [Manabe, Yasuhiro] Shinseikai Toyama Hosp, Dept Otolaryngol, Toyama, Japan. RP Saito, T (reprint author), Univ Fukui, Dept Otolaryngol Head & Neck Surg, Matsuoka Shimoaizuki 23-3, Eiheiji, Fukui 9101193, Japan. FU Ministry of Education, Science and Culture, Japan [18591861] FX This study was supported by a Grant-in-Aid for Scientific Research (C) (No. 18591861) from the Ministry of Education, Science and Culture, Japan. CR ARVIDSON K, 1981, SCAND J DENT RES, V89, P297 ARVIDSON K, 1979, SCAND J DENT RES, V87, P435 ARVIDSON K, 1980, SCIENCE, V209, P807, DOI 10.1126/science.7403846 Azzali G, 1997, ANN ANAT, V179, P37 Azzali G, 1996, Minerva Stomatol, V45, P363 BULL T R, 1965, J Laryngol Otol, V79, P479, DOI 10.1017/S0022215100063969 Cain P, 1996, EXP NEUROL, V141, P337, DOI 10.1006/exnr.1996.0169 CHEAL M, 1977, J COMP NEUROL, V172, P627, DOI 10.1002/cne.901720406 CHEAL M, 1977, J COMP NEUROL, V172, P609, DOI 10.1002/cne.901720405 CHILLA R, 1982, ACTA OTO-LARYNGOL, V94, P461, DOI 10.3109/00016488209128935 Ishii T, 1979, Nihon Jibiinkoka Gakkai Kaiho, V82, P271 Jeppsson P H, 1969, Acta Otolaryngol Suppl, V259, P1 Just T, 2006, LARYNGOSCOPE, V116, P1216, DOI 10.1097/01.mlg.0000224509.61099.29 KULLAAMIKKONEN A, 1987, GERODONTICS, V3, P131 KVETON JF, 1994, LARYNGOSCOPE, V104, P25 MILLER IJ, 1986, ANAT REC, V216, P474, DOI 10.1002/ar.1092160404 MILLER IJ, 1974, J COMP NEUROL, V158, P155, DOI 10.1002/cne.901580204 MILLER IJ, 1987, ANN NY ACAD SCI, V510, P501, DOI 10.1111/j.1749-6632.1987.tb43604.x Moon CN, 1963, LARYNGOSCOPE, V73, P392 MURRAY R G, 1969, Journal of Ultrastructure Research, V27, P444, DOI 10.1016/S0022-5320(69)80043-2 MURRAY RG, 1986, J ULTRA MOL STRUCT R, V95, P175, DOI 10.1016/0889-1605(86)90039-X ROBINSON PP, 1991, ARCH ORAL BIOL, V36, P885, DOI 10.1016/0003-9969(91)90119-F Saito Takehisa, 2000, Annals of Otology Rhinology and Laryngology, V109, P703 Saito T, 2011, ANN OTO RHINOL LARYN, V120, P300 Saito T, 2001, LARYNGOSCOPE, V111, P2064, DOI 10.1097/00005537-200111000-00037 Saito T, 2002, ANN OTO RHINOL LARYN, V111, P357 Saito T, 2001, ORL J OTO-RHINO-LARY, V63, P359, DOI 10.1159/000055774 SETA Y, 1995, ANAT EMBRYOL, V191, P83 SMITH KG, 1995, BRAIN RES, V691, P142, DOI 10.1016/0006-8993(95)00655-A Tomita H, 1986, AURIS NASUS LARYNX S, V13, P1 WHITEHEAD MC, 1995, EXP NEUROL, V132, P239, DOI 10.1016/0014-4886(95)90029-2 ZUNIGA JR, 1994, CHEM SENSES, V19, P657, DOI 10.1093/chemse/19.6.657 NR 32 TC 5 Z9 5 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD NOV PY 2011 VL 120 IS 11 BP 713 EP 721 PG 9 WC Otorhinolaryngology SC Otorhinolaryngology GA 852SN UT WOS:000297377900004 PM 22224312 ER PT J AU Kamargiannis, N Gouveris, H Katsinelos, P Katotomichelakis, M Riga, M Beltsis, A Danielides, V AF Kamargiannis, Nikolaos Gouveris, Haralampos Katsinelos, Panagiotis Katotomichelakis, Michael Riga, Maria Beltsis, Athanasios Danielides, Vasilios TI Chronic Pharyngitis Is Associated With Severe Acidic Laryngopharyngeal Reflux in Patients With Reinke's Edema SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE acid; larynx; pharyngitis; pharynx; reflux; Reinke's edema ID RELIABILITY; VALIDITY AB Objectives: We evaluated the association between pathological acidic laryngopharyngeal reflux (LPR) events and chronic pharyngitis in patients with Reinke's edema. Methods: We performed a prospective controlled study in 20 consecutive patients with Reinke's edema without pathological acidic LPR events (group A) and 40 consecutive patients with Reinke's edema with both clinical symptoms and 24-hour pH-metry suggesting acidic LPR (group B). The severity of acidic LPR was assessed by use of the Reflux Finding Score (RFS), the Reflux Symptom Index (RSI), and dual antimony probe 24-hour pH-metry. The patients were evaluated for the presence of chronic pharyngitis by clinical examination and biopsy specimens taken from the posterior pharyngeal wall. The chi(2) test was used to compare the groups for the presence of pharyngitis. In group B, the RSI, the RFS, and the total duration and number of acidic LPR events on 24-hour pH-metry were compared between patients with and without concomitant pharyngitis by use of the Mann-Whitney test. Results: Five patients of group A and 20 patients of group B had chronic pharyngitis. Therefore, more patients with Reinke's edema and clinical signs of LPR tended to have chronic pharyngitis than did those with Reinke's edema and no clinical signs of LPR, but the difference was not statistically significant (p = 0.064; odds ratio, 3.0; 95% confidence interval, 0.9 to 9.8). Among group B patients, those with pharyngitis had significantly more acidic LPR events (p <0.001) and a greater exposure time to gastric fluid (p = 0.008) than did those without pharyngitis. Their RFS and RSI did not differ significantly (p = 0.692 and p = 0.914, respectively). Conclusions: Only in the subgroup of patients with Reinke's edema and LPR was there a statistically significant correlation between the pH probe results and the incidence of clinical pharyngitis. Awareness should increase among physicians about addressing chronic pharyngitis in therapy for acidic LPR and/or Reinke's edema. C1 [Kamargiannis, Nikolaos; Gouveris, Haralampos; Katotomichelakis, Michael; Riga, Maria; Danielides, Vasilios] Democritus Univ Thrace, Sch Med, Dept Otorhinolaryngol Head & Neck Surg, Alexandroupolis, Greece. [Kamargiannis, Nikolaos] Cent Hosp, Dept Otorhinolaryngol Head & Neck Surg, Thessaloniki, Greece. [Katsinelos, Panagiotis; Beltsis, Athanasios] Cent Hosp, Endoscopy & Motil Unit, Thessaloniki, Greece. RP Danielides, V (reprint author), Alexandroupolis Univ Hosp, Dept Otorhinolaryngol Head & Neck Surg, Dragana 68100, Alexandroupolis, Greece. CR Amin SM, 2009, ANN OTO RHINOL LARYN, V118, P362 Belafsky PC, 2002, J VOICE, V16, P274, DOI 10.1016/S0892-1997(02)00097-8 Belafsky PC, 2001, LARYNGOSCOPE, V111, P1313, DOI 10.1097/00005537-200108000-00001 Johnston N, 2009, ANN OTO RHINOL LARYN, V118, P677 Koufman JA, 2002, OTOLARYNG HEAD NECK, V127, P32, DOI 10.1067/mhn.2002.125760 Wada T, 2009, J CLIN GASTROENTEROL, V43, P249, DOI 10.1097/MCG.0b013e318167b8b5 Yazici ZM, 2010, EUR ARCH OTO-RHINO-L, V267, P571, DOI 10.1007/s00405-009-1044-2 NR 7 TC 0 Z9 1 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD NOV PY 2011 VL 120 IS 11 BP 722 EP 726 PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA 852SN UT WOS:000297377900005 PM 22224313 ER PT J AU Bhattacharyya, N AF Bhattacharyya, Neil TI Benchmarks for the Durations of Ambulatory Surgical Procedures in Otolaryngology SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE ambulatory surgery; efficiency; myringotomy; septoplasty; tonsillectomy ID SURGERY CENTER AB Objectives: I undertook to determine benchmarks and variability for the surgical times associated with ambulatory otolaryngological procedures in the United States. Methods: I examined the 2006 release of the National Survey of Ambulatory Surgery and extracted all cases of otolaryngological surgery in which one, and only one, otolaryngological procedure was performed. The mean surgical times and operating room times were determined for each procedure that met reliability criteria for their estimates. A secondary analysis was computed for tonsillectomy and for tonsillectomy plus adenoidectomy according to a patient age of greater than 12 years. Results: An estimated 1.68 +/- 0.23 million otolaryngological procedures were analyzed as solitary procedures, including 507,000 cases of myringotomy with ventilation tube placement, 136,000 cases of tonsillectomy, and 429,000 cases of tonsillectomy plus adenoidectomy. The mean (+/- SE) surgical times were 8.0 +/- 0.5, 23.9 +/- 1.8, and 20.3 +/- 0.8 minutes, respectively. The total operating room times were 17.6 +/- 0.9, 48.2 +/- 2.0, and 40.7 +/- 1.1 minutes, respectively. Septoplasty with turbinectomy was the most common rhinologic procedure performed (48,000 cases analyzed) and had surgical and operating room times of 49.6 +/- 4.78 and 79.8 +/- 5.8 minutes, respectively. The surgical times for tonsillectomy and tonsillectomy plus adenoidectomy did not differ significantly in magnitude according to standard age cutoffs, although the operating room time was slightly (11.7 minutes) longer for tonsillectomy in patients more than 12 years of age (p = 0.034). Conclusions: The surgical times for the performance of the most common otolaryngological ambulatory procedures are remarkably consistent in the United States. Given the volume and consistency of these surgical procedures, they are ideal candidates for studies of cost and efficiency. C1 [Bhattacharyya, Neil] Brigham & Womens Hosp, Div Otolaryngol, Boston, MA 02115 USA. [Bhattacharyya, Neil] Harvard Univ, Sch Med, Dept Otol & Laryngol, Boston, MA 02115 USA. RP Bhattacharyya, N (reprint author), Brigham & Womens Hosp, Div Otolaryngol, 45 Francis St, Boston, MA 02115 USA. CR Bhattacharyya N, 2010, LARYNGOSCOPE, V120, P635, DOI 10.1002/lary.20777 Bhattacharyya N, 2010, OTOLARYNG HEAD NECK, V143, P680, DOI 10.1016/j.otohns.2010.06.918 Cullen KA, 2009, NATL HLTH STAT REPOR, V28, P1 Dexter Franklin, 2005, Curr Opin Anaesthesiol, V18, P195, DOI 10.1097/01.aco.0000162840.02087.15 Grisel J, 2009, OTOLARYNG HEAD NECK, V141, P701, DOI 10.1016/j.otohns.2009.09.002 Freeman Karen, 2008, J Perianesth Nurs, V23, P387, DOI 10.1016/j.jopan.2008.08.003 Lynch Frank, 2004, J Am Coll Radiol, V1, P965, DOI 10.1016/j.jacr.2004.06.026 Bhattacharyya N, 2010, LARYNGOSCOPE, V120, P821, DOI 10.1002/lary.20852 Lemos P, 2009, J CLIN ANESTH, V21, P200, DOI 10.1016/j.jclinane.2008.08.016 Sorge M, 2001, Can Oper Room Nurs J, V19, P7 Trentman TL, 2010, AM J SURG, V200, P64, DOI 10.1016/j.amjsurg.2009.06.029 NR 11 TC 7 Z9 7 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD NOV PY 2011 VL 120 IS 11 BP 727 EP 731 PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA 852SN UT WOS:000297377900006 PM 22224314 ER PT J AU Humphreys, I Saraiya, S Belenky, W Dworkin, J AF Humphreys, Ian Saraiya, Sonal Belenky, Walter Dworkin, James TI Nasal Packing With Strips of Cured Pork as Treatment for Uncontrollable Epistaxis in a Patient With Glanzmann Thrombasthenia SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE epistaxis; Glanzmann thrombasthenia; pork ID RECOMBINANT FACTOR VIIA; CHILDREN AB Objectives: Glanzmann thrombasthenia is a rare disorder of platelet function that may result in life-threatening hemorrhage, particularly from the nasal vaults. Various medical therapies (such as recombinant factor VII, antifibrinolytic agents. and blood transfusions) and surgical therapies (such as nasal packing, electrocautery, laser coagulation, septoplasty, and embolization) have been described with various degrees of success. Methods: We present a unique case report of a 4-year-old child with known Glanzmann thrombasthenia and two separate episodes of life-threatening epistaxis that were treated successfully by nasal packing with strips of cured pork because of special circumstances. Results: Cured salted pork crafted as a nasal tampon and packed within the nasal vaults successfully stopped nasal hemorrhage promptly, effectively, and without sequelae. In both applications, the patient had complete cessation of nasal bleeding within 24 hours, and was discharged within 72 hours after treatment. Conclusions: To our knowledge, this represents the first description of nasal packing with strips of cured pork for treatment of life-threatening hemorrhage in a patient with Glanzmann thrombasthenia. C1 [Humphreys, Ian; Dworkin, James] Michigan State Univ, Dept Otolaryngol Head & Neck Surg, Detroit Med Ctr, Detroit, MI 48201 USA. [Saraiya, Sonal; Belenky, Walter] Childrens Hosp Michigan, Dept Pediat Otolaryngol Head & Neck Surg, Detroit Med Ctr, Detroit, MI 48201 USA. RP Humphreys, I (reprint author), Michigan State Univ, Dept Otolaryngol Head & Neck Surg, Detroit Med Ctr, 4160 John Rd,Suite 1007, Detroit, MI 48201 USA. CR Bhat S, 2011, INDIAN J PEDIATR, V78, P961, DOI 10.1007/s12098-011-0364-6 Caglar K, 2003, PEDIATR HEMAT ONCOL, V20, P435, DOI 10.1080/08880010390220135 Chuansumrit A, 1999, THROMB HAEMOSTASIS, V82, P1778 Depner C, 2010, BLOOD COAGUL FIBRIN, V21, P283, DOI 10.1097/MBC.0b013e328330e683 Glanzmann E, 1918, J KINDERKR, V88, P113 GUARISCO JL, 1987, LARYNGOSCOPE, V97, P336 Martin I, 2002, BRIT J HAEMATOL, V119, P991, DOI 10.1046/j.1365-2141.2002.03936.x Nurden AT, 2006, ORPHANET J RARE DIS, V1, DOI 10.1186/1750-1172-1-10 Rosas RR, 2010, LARYNGOSCOPE, V120, P2374, DOI 10.1002/lary.21034 Tengborn L, 1996, THROMB HAEMOSTASIS, V75, P981 Zinke R A, 2010, Haemophilia, V16, P701, DOI 10.1111/j.1365-2516.2010.02222.x 1940, TIME MAGAZINE 0617 NR 12 TC 3 Z9 3 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD NOV PY 2011 VL 120 IS 11 BP 732 EP 736 PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA 852SN UT WOS:000297377900007 PM 22224315 ER PT J AU Quesnel, S Nguyen, Y Campo, P Hermine, O Ribeil, JA Elmaleh, M Grayeli, AB Ferrary, E Sterkers, O Couloigner, V AF Quesnel, Stephanie Nguyen, Yann Campo, Pierre Hermine, Olivier Ribeil, Jean-Antoine Elmaleh, Monique Grayeli, Alexis Bozorg Ferrary, Evelyne Sterkers, Olivier Couloigner, Vincent TI Protective Effect of Systemic Administration of Erythropoietin on Auditory Brain Stem Response and Compound Action Potential Thresholds in an Animal Model of Cochlear Implantation SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE apoptosis; cochlea; guinea pig; hearing loss; systemic route ID ROUND WINDOW DEXAMETHASONE; GUINEA-PIG MODEL; HEARING-LOSS; RESIDUAL HEARING; INNER-EAR; APOPTOSIS; ISCHEMIA; SURGERY; TRAUMA; FLUID AB Objectives: An animal model of cochlear implantation has been developed, and the hearing threshold was evaluated after different surgical procedures. The effect of perioperative systemic administration of erythropoietin on the hearing loss induced by cochlear implantation was tested. Methods: Twenty-nine guinea pigs with normal hearing underwent implantation of a 254-mu m-diameter array through a cochleostomy. The effects on hearing of cochleostomy and transient and long-term array implantation (21 days) were assessed by testing of the auditory brain stem responses and compound action potentials. Eleven implanted animals received intraperitoneal administration of erythropoietin. Selected computed tomographic scans and cochlear histologic studies were performed 1 month after implantation to confirm proper placement of the array. The erythropoietin concentration at the time of surgery was assessed in samples of perilymph, cerebrospinal fluid, and blood. Results: The cochleostomy and transient array insertion had no effect on hearing thresholds. Long-term array implantation induced a stable decrease of hearing threshold (30 dB), a decrease that was reduced by 12 dB in erythropoietin-treated animals. The erythropoietin-treated animals had better hearing preservation at higher frequencies. Fibrosis surrounding the array was seen in both groups. Conclusions: The hearing loss observed was probably due to the presence of the array in the cochlea. The intraperitoneal injection of erythropoietin improved the hearing threshold shift induced by implantation. C1 [Quesnel, Stephanie; Nguyen, Yann; Grayeli, Alexis Bozorg; Ferrary, Evelyne; Sterkers, Olivier; Couloigner, Vincent] INSERM, UMR S867, F-75018 Paris, France. [Quesnel, Stephanie; Nguyen, Yann; Grayeli, Alexis Bozorg; Ferrary, Evelyne; Sterkers, Olivier; Couloigner, Vincent] Univ Paris 07, Paris, France. [Hermine, Olivier; Ribeil, Jean-Antoine] Hop Necker Enfants Malad, AP HP, Dept Hematol, Paris, France. [Couloigner, Vincent] Hop Necker Enfants Malad, AP HP, Dept Otolaryngol, Paris, France. [Elmaleh, Monique] Hop Robert Debre, AP HP, F-75019 Paris, France. [Hermine, Olivier; Ribeil, Jean-Antoine] CNRS, UMR 8147, Paris, France. [Hermine, Olivier; Ribeil, Jean-Antoine; Couloigner, Vincent] Univ Paris 05, Paris, France. [Quesnel, Stephanie; Nguyen, Yann; Grayeli, Alexis Bozorg; Ferrary, Evelyne; Sterkers, Olivier] Beaujon Hosp, AP HP, Dept Otolaryngol, Clichy, France. [Campo, Pierre] Inst Natl Rech & Secur, Dept Contaminants & Hlth, F-54501 Vandoeuvre Les Nancy, France. RP Quesnel, S (reprint author), INSERM, UMR S867, 16 Rue Henri Huchard, F-75018 Paris, France. FU Inserm (Universite Paris 7 Denis Diderot, France); "Voir et Entendre" Foundation (Paris, France); Fondation de l'Avenir (Paris, France) FX This project was supported by grants from Inserm (Universite Paris 7 Denis Diderot, France), "Voir et Entendre" Foundation (Paris, France), and Fondation de l'Avenir (Paris, France). CR Andreeva N, 2006, NEUROSCI LETT, V396, P86, DOI 10.1016/j.neulet.2005.11.013 Brines ML, 2000, P NATL ACAD SCI USA, V97, P10526, DOI 10.1073/pnas.97.19.10526 Caye-Thomasen P, 2005, HEARING RES, V203, P21, DOI 10.1016/j.heares.2004.11.017 Chang A, 2009, HEARING RES, V255, P67, DOI 10.1016/j.heares.2009.05.010 Chattopadhyay A, 2000, BIOCHEM PHARMACOL, V59, P419, DOI 10.1016/S0006-2952(99)00277-4 COULOIGNER V, 2001, J FR ORL, V50, P314 Eastwood H, 2010, HEARING RES, V259, P24, DOI 10.1016/j.heares.2009.08.010 Eshraghi AA, 2006, OTOL NEUROTOL, V27, P504, DOI 10.1097/00129492-200606000-00012 Eshraghi AA, 2005, OTOL NEUROTOL, V26, P442, DOI 10.1097/01.mao.0000169791.53201.e1 Eshraghi AA, 2007, OTOL NEUROTOL, V28, P842, DOI 10.1097/MAO.0b013e31805778fc Gantz BJ, 2005, LARYNGOSCOPE, V115, P796, DOI 10.1097/01.MLG.0000157695.07536.D2 GREENWOOD DD, 1990, J ACOUST SOC AM, V87, P2592, DOI 10.1121/1.399052 Grimm C, 2002, NAT MED, V8, P718, DOI 10.1038/nm723 James Chris J, 2006, Audiol Neurootol, V11 Suppl 1, P57, DOI 10.1159/000095615 James DP, 2008, AUDIOL NEURO-OTOL, V13, P86, DOI 10.1159/000111780 Kawakami M, 2001, J BIOL CHEM, V276, P39469, DOI 10.1074/jbc.M105832200 Kobayashi T, 1999, AM J OTOL, V20, P179 LEHNHARDT E, 1993, HNO, V41, P356 Lenarz Thomas, 2006, Audiol Neurootol, V11 Suppl 1, P34, DOI 10.1159/000095612 Maiese K, 2008, PROG NEUROBIOL, V85, P194, DOI 10.1016/j.pneurobio.2008.02.002 Malgrange B, 2002, HEARING RES, V170, P48, DOI 10.1016/S0378-5955(02)00451-3 Nguyen Y, 2009, ACTA OTO-LARYNGOL, V129, P1153, DOI 10.3109/00016480802629440 Plontke SK, 2007, AUDIOL NEURO-OTOL, V12, P37, DOI 10.1159/000097246 Scarpidis U, 2003, OTOL NEUROTOL, V24, P409, DOI 10.1097/00129492-200305000-00011 Siren AL, 2001, EUR ARCH PSY CLIN N, V251, P179, DOI 10.1007/s004060170038 Statler PA, 2007, PEDIATR RES, V61, P671, DOI 10.1203/pdr.0b013e31805341dc STERKERS O, 1982, AM J PHYSIOL, V243, pF173 Talbot KN, 2008, CLIN OTOLARYNGOL, V33, P536, DOI 10.1111/j.1749-4486.2008.01822.x Thorne M, 1999, LARYNGOSCOPE, V109, P1661, DOI 10.1097/00005537-199910000-00021 Villa P, 2003, J EXP MED, V198, P971, DOI 10.1084/jem.20021067 NR 30 TC 1 Z9 2 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD NOV PY 2011 VL 120 IS 11 BP 737 EP 747 PG 11 WC Otorhinolaryngology SC Otorhinolaryngology GA 852SN UT WOS:000297377900008 PM 22224316 ER PT J AU Berg, EE Kolachala, V Branski, RC Muller, S Johns, MM AF Berg, Eric E. Kolachala, Vasantha Branski, Ryan C. Muller, Susan Johns, Michael M. TI Pathologic Effects of External-Beam Irradiation on Human Vocal Folds SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article; Proceedings Paper CT Meeting of the American-Broncho-Esophagological-Association CY APR 27-28, 2011 CL Chicago, IL SP Amer Broncho Esophagol Assoc DE fibrosis; radiation; vocal fold ID RADIATION-THERAPY; VOICE; RADIOTHERAPY; LARYNGEAL; FIBROSIS; QUALITY; CANCER; NECK; HEAD AB Objectives: We sought to better characterize pathologic changes that occur in the human vocal fold after radiotherapy for head and neck cancer. Methods: In a blinded, controlled study of archived tissue, we evaluated postirradiation salvage laryngectomy vocal fold tissue without evidence of malignant disease. Clinical and demographic patient data were collected. In a blinded fashion, irradiated tissue was compared to nonirradiated, benign control tissue. Histomorphometric analysis was used to assess muscle and collagen organization, superficial lamina propria (SLP) and vocal ligament thickness, vocalis muscle fiber area, collagen content, and hyaluronic acid content. Immunohistochemical analysis was used to assess the content of type I collagen, type IV collagen, vimentin, fibronectin, alpha-smooth muscle actin, matrix metalloproteinase 9, and laminin. Results: Twenty irradiated vocal folds were evaluated and compared to control specimens. Collagen and muscle disorganization was noted in the irradiated specimens. The SLP and vocal ligament thicknesses and the mean muscle fiber diameters did not differ significantly. The SLP fibronectin and the vocalis muscle and SLP collagen content were significantly increased in the irradiated vocal folds, and the SLP collagen content increased significantly with time between irradiation and resection. The laminin content of irradiated vocalis muscles was significantly decreased. Conclusions: Radiotherapy results in significant vocal fold tissue changes. Having more precisely defined these changes, we plan continued investigation seeking targeted preventive and therapeutic interventions for improved vocal quality following radiotherapy. C1 [Berg, Eric E.; Muller, Susan] Emory Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, Atlanta, GA USA. [Muller, Susan] Emory Univ, Sch Med, Dept Pathol, Atlanta, GA 30322 USA. [Kolachala, Vasantha; Johns, Michael M.] Emory Univ, Emory Voice Ctr, Atlanta, GA USA. [Branski, Ryan C.] NYU, Voice Ctr, New York, NY USA. RP Johns, MM (reprint author), Emory Univ Hosp Midtown, Emory Voice Ctr, Med Off Tower,9th Floor,550 Peachtree St, Atlanta, GA 30308 USA. CR Aref A, 1997, RADIOTHER ONCOL, V45, P149, DOI 10.1016/S0167-8140(97)00154-0 Dagli AS, 1997, EUR ARCH OTO-RHINO-L, V254, P78, DOI 10.1007/BF01526184 Fung K, 2001, LARYNGOSCOPE, V111, P1920, DOI 10.1097/00005537-200111000-00009 Hansen JK, 2006, J VOICE, V20, P110, DOI 10.1016/j.jvoice.2004.12.005 Hirano S, 2004, LARYNGOSCOPE, V114, P2161, DOI 10.1097/01.mlg.0000149450.37640.db Hirano S, 2005, ANN OTO RHINOL LARYN, V114, P304 LEHMAN JJ, 1988, OTOLARYNG HEAD NECK, V98, P121 LIU D, 2006, J CHIN CLIN MED, V1, P361 MENDENHALL WM, 1995, SEMIN SURG ONCOL, V11, P256, DOI 10.1002/ssu.2980110311 REMY J, 1991, RADIAT RES, V125, P14, DOI 10.2307/3577976 SINGER II, 1986, AM J PATHOL, V125, P258 Takiguchi Y, 2003, J LARYNGOL OTOL, V117, P658 Zhou Y, 2010, MOL MED REP, V3, P809, DOI 10.3892/mmr.2010.326 NR 13 TC 0 Z9 0 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD NOV PY 2011 VL 120 IS 11 BP 748 EP 754 PG 7 WC Otorhinolaryngology SC Otorhinolaryngology GA 852SN UT WOS:000297377900009 PM 22224317 ER PT J AU Sun, QJ Chum, JM Bautista, TG Pilowsky, PM Berkowitz, RG AF Sun, Qi-Jian Chum, Jia Min Bautista, Tara G. Pilowsky, Paul M. Berkowitz, Robert G. TI Neuronal Mechanisms Underlying the Laryngeal Adductor Reflex SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article; Proceedings Paper CT Meeting of the American-Broncho-Esophagological-Association CY APR 27-28, 2011 CL Chicago, IL SP Amer Broncho Esophagol Assoc DE expiratory laryngeal motoneuron; laryngeal adductor reflex; superior laryngeal nerve ID THYROARYTENOID MUSCLE RESPONSES; NUCLEUS TRACTUS SOLITARIUS; AIR-PRESSURE STIMULATION; LONG-LATENCY RESPONSES; SPASMODIC DYSPHONIA; NERVE-STIMULATION; AWAKE HUMANS; CLOSURE REFLEX; RAT; MOTONEURONS AB Objectives: Electromyographic studies of the laryngeal adductor reflex, glottal closure occurring in response to laryngeal stimulation, have demonstrated an early ipsilateral response (RI) and a late bilateral response (R2). To better define the physiologic properties of these responses, we recorded responses from expiratory laryngeal motoneurons (ELMs) in rats during stimulation of the superior laryngeal nerve (SLN). Methods: Single unit extracellular recordings were obtained from 5 ELMs, identified by their antidromic responses to recurrent laryngeal nerve stimulation and postinspiratory firing pattern, in 4 Sprague-Dawley rats. Results:: Unilateral stimulation of the SLN (at 20 Hz) stopped both phrenic nerve inspiratory activity and ELM postinspiratory activity. However, the ELMs displayed robust tonic firing, consisting of non-respiratory burst activity and single action potentials. The single action potentials were identified as short-latency ones (5 to 10 ms) activated by ipsilateral SLN stimulation, with an occurrence rate of 90%, and long-latency ones (20 to 50 ms) activated by bilateral SLN stimulation, with occurrence rates of 47% on the ipsilateral side and 58% on the contralateral side. Conclusions: The RI response appears to be the result of the short-latency action potentials, orthodromically activated by ipsilateral stimulation of the SLN. The R2 response is likely to be a result of the long-latency action potentials that can be recorded from ELMs on both sides. C1 [Sun, Qi-Jian; Bautista, Tara G.; Pilowsky, Paul M.; Berkowitz, Robert G.] Macquarie Univ, Australian Sch Adv Med, Sydney, NSW 2109, Australia. [Chum, Jia Min; Berkowitz, Robert G.] Western Hosp, Dept Otolaryngol Head & Neck Surg, Melbourne, Vic, Australia. RP Pilowsky, PM (reprint author), Macquarie Univ, Australian Sch Adv Med, L1F10A, Sydney, NSW 2109, Australia. CR Ambalavanar R, 2002, J NEUROPHYSIOL, V87, P1252, DOI 10.1152/jn.00595.2001 Aviv JE, 1999, ANN OTO RHINOL LARYN, V108, P725 Barkmeier JM, 2000, J NEUROPHYSIOL, V83, P1264 Berkowitz RG, 2009, ANN OTO RHINOL LARYN, V118, P791 Berkowitz RG, 2005, LARYNGOSCOPE, V115, P105, DOI 10.1097/01.mlg.0000150695.15883.a4 Bhabu P, 2003, ANN OTO RHINOL LARYN, V112, P834 Bowden REM, 1974, EAR DRAINAGE VENTILA, P370 COHEN LG, 1989, NEUROLOGY, V39, P572 Deleyiannis FWB, 1999, ANN OTO RHINOL LARYN, V108, P612 DIETRICH WD, 1982, BRAIN RES, V237, P254, DOI 10.1016/0006-8993(82)90576-5 Gestreau C, 2000, EXP BRAIN RES, V130, P27, DOI 10.1007/s002210050003 GODING GS, 1987, OTOLARYNG HEAD NECK, V97, P28 HARAGUCHI S, 1983, ANN OTO RHINOL LARYN, V92, P24 IKARI T, 1980, ANN OTO RHINOL LARYN, V89, P220 Jean A, 2001, PHYSIOL REV, V81, P929 Kearney PR, 2005, ANN OTO RHINOL LARYN, V114, P264 LOGEMANN JA, 1992, AM J PHYSIOL, V262, pG338 LUDLOW CL, 1995, ANN OTO RHINOL LARYN, V104, P928 LUDLOW CL, 1992, ANN OTO RHINOL LARYN, V101, P127 Nguyen ATD, 2005, SLEEP, V28, P585 Phua SY, 2005, THORAX, V60, P488, DOI 10.1136/thx.2004.033894 PILOWSKY PM, 1990, J COMP NEUROL, V301, P604, DOI 10.1002/cne.903010409 REIS DJ, 1981, J AUTONOM NERV SYST, V3, P321, DOI 10.1016/0165-1838(81)90073-4 SASAKI CT, 1976, ARCH OTOLARYNGOL, V102, P400 Schindler A, 2010, ANN OTO RHINOL LARYN, V119, P71 Scott AR, 2010, ANN OTO RHINOL LARYN, V119, P54 Sun QJ, 2011, J PHYSIOL-LONDON, V589, P1819, DOI 10.1113/jphysiol.2010.203794 Sun QJ, 1998, BRAIN RES, V809, P204, DOI 10.1016/S0006-8993(98)00872-5 Thompson DM, 2005, ANN OTO RHINOL LARYN, V114, P258 Yamashita T, 1997, OTOLARYNG HEAD NECK, V117, P521, DOI 10.1016/S0194-5998(97)70025-1 NR 30 TC 6 Z9 6 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD NOV PY 2011 VL 120 IS 11 BP 755 EP 760 PG 6 WC Otorhinolaryngology SC Otorhinolaryngology GA 852SN UT WOS:000297377900010 PM 22224318 ER PT J AU Weissbrod, P Pitman, MJ Sharma, S Bender, A Schaefer, SD AF Weissbrod, Philip Pitman, Michael J. Sharma, Sansar Bender, Aaron Schaefer, Steven D. TI Quantity and Three-Dimensional Position of the Recurrent and Superior Laryngeal Nerve Lower Motor Neurons in a Rat Model SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article; Proceedings Paper CT Annual Meeting of the American-Broncho-Esophagological-Association CY APR 28-29, 2010 CL Las Vegas, NV SP Amer Broncho Esophagol Assoc DE animal model; Fluoro-Gold; Fluoro-Ruby; laryngeal nerve; lower motor neuron ID REINNERVATION; INJURY; ELECTROMYOGRAPHY; TRANSECTION; RECOVERY; TRACERS; NUCLEUS AB Objectives: We sought to elucidate the 3-dimensional position and quantify the lower motor neurons (LMNs) of the recurrent laryngeal nerve (RLN) and the superior laryngeal nerve (SLN) in a rat model. Quantification and mapping of these neurons will enhance the usefulness of the rat model in the study of reinnervation following trauma to these nerves. Methods: Female Sprague-Dawley rats underwent microsurgical transection of the RLN, the SLN, or both the RLN and SLN or sham surgery. After transection, either Fluoro-Ruby (FR) or Fluoro-Gold (FG) was applied to the proximal nerve stumps. The brain stems were harvested, sectioned, and examined for fluorolabeling. The LMNs were quantified, and their 3-dimensional position within the nucleus ambiguus was mapped. Results: Labeling of the RLN was consistent regardless of the labeling agent used. A mean of 243 LMNs was documented for the RLN. The SLN labeling with FR was consistent and showed a mean of 117 LMNs; however, FG proved to be highly variable in labeling the SLN. The SLN LMNs lie rostral and ventral to those of the RLN. In the sham surgical condition, FG was noted to contaminate adjacent tissues - in particular, in the region of the SLN. Conclusions: Fluor labeling is an effective tool to locate and quantify the LMNs of the RLN and SLN. The LMN positions; and counts were consistent when FR was used in labeling of either the RLN or the SLN. Fluoro-Gold, however, because of its tendency to contaminate surrounding structures, can only be used to label the RLN. Also, as previously reported, the SLN LMNs lie rostral and ventral to those of the RLN. This information results in further clarification of a rat model of RLN injury that may be used to investigate the effects of neurotrophic factors on RLN reinnervation. C1 [Weissbrod, Philip; Pitman, Michael J.; Schaefer, Steven D.] New York Eye & Ear Infirm, Dept Otolaryngol, New York, NY 10003 USA. [Sharma, Sansar; Bender, Aaron] New York Med Coll, Dept Cell Biol, Valhalla, NY 10595 USA. RP Pitman, MJ (reprint author), New York Eye & Ear Infirm, Dept Otolaryngol, 310 E 14th St,6th Floor, New York, NY 10003 USA. CR Ahmed FAKM, 2001, EXP NEUROL, V167, P451, DOI 10.1006/exnr.2000.7562 BIEGER D, 1987, J COMP NEUROL, V262, P546, DOI 10.1002/cne.902620408 Choi D, 2002, J NEUROSCI METH, V117, P167, DOI 10.1016/S0165-0270(02)00098-5 FLINT PW, 1991, ANN OTO RHINOL LARYN, V100, P797 Hayashi A, 2007, J RECONSTR MICROSURG, V23, P381, DOI 10.1055/s-2007-992344 HINRICHSEN CFL, 1981, EXP NEUROL, V74, P341, DOI 10.1016/0014-4886(81)90174-6 Hydman J, 2007, ANN OTO RHINOL LARYN, V116, P623 Mori Y, 2007, LARYNGOSCOPE, V117, P1313, DOI 10.1097/MLG.0b013e31805f681f Pascual-Font A, 2006, Acta Otorrinolaringol Esp, V57, P295 Pascual-Font Arán, 2008, Acta Otorrinolaringol Esp, V59, P163 Pitman MJ, 2011, LARYNGOSCOPE, V121, P320, DOI 10.1002/lary.21290 PORTILLO F, 1998, BRAIN BEHAV EVOLUT, V32, P220 Shiotani A, 1999, ARCH OTOLARYNGOL, V125, P555 Tessema B, 2009, LARYNGOSCOPE, V119, P1644, DOI 10.1002/lary.20293 Tessema B, 2008, ANN OTO RHINOL LARYN, V117, P604 NR 15 TC 1 Z9 1 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD NOV PY 2011 VL 120 IS 11 BP 761 EP 768 PG 8 WC Otorhinolaryngology SC Otorhinolaryngology GA 852SN UT WOS:000297377900011 PM 22224319 ER PT J AU Zeitels, SM Barbu, AM Landau-Zemer, T Lopez-Guerra, G Burns, JA Friedman, AD Freeman, MW Halvorsen, YD Hillman, RE AF Zeitels, Steven M. Barbu, Anca M. Landau-Zemer, Tali Lopez-Guerra, Gerardo Burns, James A. Friedman, Aaron D. Freeman, Mason W. Halvorsen, Yuan-Di Hillman, Robert E. TI Local Injection of Bevacizumab (Avastin) and Angiolytic KTP Laser Treatment of Recurrent Respiratory Papillomatosis of the Vocal Folds: A Prospective Study SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE Avastin; bevacizumab; glottis; KTP laser; larynx; laser; papilloma; papillomatosis; recurrent respiratory papillomatosis; RRP; vocal cord; vocal fold; voice ID TUMOR ANGIOGENESIS; ANESTHESIA; DYSPLASIA; CANCER; SAFETY AB Objectives: Photoangiolytic laser treatment of recurrent respiratory papillomatosis (RRP) is effective, but does not reliably prevent recurrence. Therefore, sublesional injections of the antiangiogenic agent bevacizumab (Avastin) were given to assess the adjunctive effect on disease recurrence. Since bevacizumab is a new therapeutic modality for RRP, there were also primary safety objectives to determine whether there was a negative impact on the voice and whether there were local or systemic complications. Methods: A prospective open-label investigation was conducted in 20 adult patients with bilateral vocal fold RRP. The patients underwent planned 532-nm pulsed KTP laser photoangiolysis of bilateral glottal disease 4 times with an approximately 6-week interval between procedures. At each planned laser procedure, the vocal fold that on initial presentation had a greater volume of disease also underwent 4 serial sublesional bevacizumab injections (7.5 to 12.5 mg in 0.3 to 0.5 mL). A sham injection with saline solution was administered to the other vocal fold as a control. Disease resolution was compared between subjects' vocal folds, and objective measures of vocal function (acoustic, aerodynamic), as well as patients' self-assessments of vocal function (Voice-Related Quality of Life survey), were obtained. Results: All 20 patients completed the study, and there were no local or systemic complications. After 4 injections, 3 of the 20 patients had no discernible disease in either vocal fold. Of the remaining 17 subjects, 16 had less disease in the bevacizumab-treated vocal fold despite starting with more disease. Only 1 of the 17 had more disease in the bevacizumab-treated vocal fold after 4 injections. Moreover, 7 of the 20 patients (35%) did not require a laser procedure in the vocal fold that had received 4 bevacizumab injections, as compared with 3 of the 20 vocal folds (15%) that were treated with laser alone. All of the vocal function measures displayed statistically significant posttreatment improvements, except for average fundamental frequency in the 3 female patients, in whom it fell below the normal range. Conclusions: This prospective investigation provided evidence that bevacizumab injections enhanced KTP laser treatment of glottal papillomatosis without systemic or local complications. Coupling the antiangiogenesis agent bevacizumab with KTP laser photoangiolysis is conceptually synergistic and scientifically promising since the mechanisms of action are complementary. C1 [Zeitels, Steven M.; Barbu, Anca M.; Landau-Zemer, Tali; Lopez-Guerra, Gerardo; Burns, James A.; Friedman, Aaron D.; Hillman, Robert E.] Massachusetts Gen Hosp, Ctr Laryngeal Surg & Voice Rehabil, Boston, MA 02114 USA. [Zeitels, Steven M.; Barbu, Anca M.; Landau-Zemer, Tali; Lopez-Guerra, Gerardo; Burns, James A.; Friedman, Aaron D.; Hillman, Robert E.] Harvard Univ, Sch Med, Dept Surg, Boston, MA 02115 USA. [Freeman, Mason W.; Halvorsen, Yuan-Di] Harvard Univ, Sch Med, Dept Med, Boston, MA 02115 USA. [Freeman, Mason W.; Halvorsen, Yuan-Di] Massachusetts Gen Hosp, Translat Med Grp, Ctr Computat & Integrat Biol, Boston, MA 02114 USA. [Hillman, Robert E.] Massachusetts Gen Hosp, Inst Hlth Profess, Boston, MA 02114 USA. RP Zeitels, SM (reprint author), Massachusetts Gen Hosp, Ctr Laryngeal Surg & Voice Rehabil, 1 Bowdoin Sq,11th Floor, Boston, MA 02114 USA. FU Eugene B. Casey Foundation; V Foundation; Institute of Laryngology and Voice Restoration; Harvard Catalyst Program FX This work was supported in part by the Eugene B. Casey Foundation, the V Foundation, the Institute of Laryngology and Voice Restoration, and the Harvard Catalyst Program. CR Burns JA, 2007, LARYNGOSCOPE, V117, P1500, DOI 10.1097/MLG.0b013e318064e869 Eskens FALM, 2008, EUR J CANCER, V44, P2350, DOI 10.1016/j.ejca.2008.07.042 Folkman J, 1995, NEW ENGL J MED, V333, P1757 Folkman J., 2001, HARRISONS TXB INTERN, P517 FOLKMAN J, 1985, ADV CANCER RES, V43, P175 FOLKMAN J, 1971, NEW ENGL J MED, V285, P1182 Fung AE, 2006, BRIT J OPHTHALMOL, V90, P1344, DOI 10.1136/bjo.2006.099598 Gray SD, 1999, LARYNGOSCOPE, V109, P845, DOI 10.1097/00005537-199906000-00001 Hogikyan ND, 1999, J VOICE, V13, P557, DOI 10.1016/S0892-1997(99)80010-1 Hooper FH, 1882, ARCH LARYNGOL, V3, P334 INCZE JS, 1977, CANCER, V39, P1634, DOI 10.1002/1097-0142(197704)39:4<1634::AID-CNCR2820390438>3.0.CO;2-U Jako GJ, 1966, ANN M AM MED ASS Lee AS, 2004, J VOICE, V18, P551, DOI 10.1016/j.jvoice.2003.07.007 Lynch SS, 2007, ANN PHARMACOTHER, V41, P614, DOI 10.1345/aph.1H316 Nagel S, 2009, Pneumologie, V63, P387, DOI 10.1055/s-0029-1214714 Rahbar R, 2005, ANN OTO RHINOL LARYN, V114, P289 Simonds J, 2009, LARYNGOSCOPE, V119, P988, DOI 10.1002/lary.20159 Wu L, 2008, GRAEF ARCH CLIN EXP, V246, P81, DOI 10.1007/s00417-007-0660-z Zeitels SM, 2008, ANN OTO RHINOL LARYN, V117, P3 Zeitels SM, 2001, ATLAS PHONOMICROSURG, P119 Zeitels SM, 1997, ANN OTO RHINOL LARYN, V106, P533 Zeitels SM, 2004, ANN OTO RHINOL LARYN, V113, P265 Zeitels SM, 1995, LARYNGOSCOPE S, V105, P1 Zeitels SM, 2009, ANN OTOL RHINOL S201, V118, P1 Zeitels Steven M, 2007, Curr Opin Otolaryngol Head Neck Surg, V15, P394, DOI 10.1097/MOO.0b013e3282f1fbb2 Zeitels SM, 2006, ANN OTO RHINOL LARYN, V115, P571 Zeitels SM, 2006, ANN OTO RHINOL LARYN, V115, P679 Zeitels SM, 2007, ANN OTO RHINOL LARYN, V116, P317 ZEITELS SM, 1991, OTOLARYNG HEAD NECK, V105, P478 NR 29 TC 12 Z9 12 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD OCT PY 2011 VL 120 IS 10 BP 627 EP 634 PG 8 WC Otorhinolaryngology SC Otorhinolaryngology GA 837MY UT WOS:000296209100001 PM 22097147 ER PT J AU Griffin, GR Hoesli, R Thorne, MC AF Griffin, Garrett R. Hoesli, Rebecca Thorne, Marc C. TI Validity and Efficacy of a Pediatric Airway Foreign Body Training Course in Resident Education SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE foreign body; patient simulation ID OPERATING-ROOM; PERSPECTIVES; PERFORMANCE; MODEL AB Objectives: We evaluated the validity and efficacy of a pediatric airway foreign body simulation for otolaryngology resident training. Methods: We created a course using a high-fidelity toddler mannequin designed to instruct and evaluate otolaryngology residents in pediatric airway foreign body management. Seven junior and 5 senior residents participated. Their performance was evaluated by 2 observers using an Objective Structured Assessment of Technical Skills (OSATS) instrument. Results: By the third trial, all junior and senior residents scored a proficiency level of "independent without errors" or "independent and efficient," and the performance of the junior residents was not different from that of the senior residents. After completing the course, the junior residents self-rated their abilities as commensurate with those of a senior resident, and senior residents rated themselves capable of performing foreign body extraction without supervision. All participants felt that the course and simulator had good overall realism and a realistic feel, demonstrating face validity. Perhaps most importantly, the residents' highest ratings were for "facilitated management of complications" and "facilitated working with the operating room team" areas difficult,to teach during live surgical procedures. Conclusions: This pediatric airway foreign body course using a high-fidelity simulator has face and construct validity, and results in statistically improved performance and self-evaluation of all participants. C1 [Griffin, Garrett R.] Univ Michigan Hlth Syst, Dept Otolaryngol Head & Neck Surg, Taubman Ctr 1904, Ann Arbor, MI 48109 USA. RP Griffin, GR (reprint author), Univ Michigan Hlth Syst, Dept Otolaryngol Head & Neck Surg, Taubman Ctr 1904, 1500 Med Ctr Dr,SPC 5312, Ann Arbor, MI 48109 USA. CR *ACCR COUNC GRAD M, 2004, OT CAS LOGS NAT DAT Deutsch ES, 2009, ANN OTO RHINOL LARYN, V118, P81 Deutsch ES, 2007, ANN OTO RHINOL LARYN, V116, P319 Deutsch ES, 2008, ARCH OTOLARYNGOL, V134, P625, DOI 10.1001/archotol.134.6.625 Ericsson KA, 2004, ACAD MED, V79, pS70, DOI 10.1097/00001888-200410001-00022 Franzese CB, 2007, OTOLARYNG CLIN N AM, V40, P1227, DOI 10.1016/j.otc.2007.07.004 Ishman SL, 2010, LARYNGOSCOPE, V120, P2294, DOI 10.1002/lary.21067 Leach DC, 2004, MED EDUC, V38, P12, DOI 10.1046/j.1365-2923.2004.01732.x Seymour NE, 2002, ANN SURG, V236, P458, DOI 10.1097/01.SLA.0000028969.51489.B4 Van Sickle KR, 2006, SURG INNOV, V13, P198, DOI 10.1177/1553350606293370 Walter AJ, 2006, OBSTET GYN CLIN N AM, V33, P233, DOI 10.1016/j.ogc.2006.01.003 Zur KB, 2009, PEDIATR ANESTH, V19, P109, DOI 10.1111/j.1460-9592.2009.03006.x NR 12 TC 3 Z9 3 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD OCT PY 2011 VL 120 IS 10 BP 635 EP 640 PG 6 WC Otorhinolaryngology SC Otorhinolaryngology GA 837MY UT WOS:000296209100002 PM 22097148 ER PT J AU Fowler, LP Awan, SN Gorham-Rowan, M Morris, R AF Fowler, Linda P. Awan, Shaheen N. Gorham-Rowan, Mary Morris, Richard TI Investigation of Fatigue, Delayed-Onset Muscle Soreness, and Spectral-Based Cepstral Measurements in Healthy Speakers After Neuromuscular Electrical Stimulation SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE cepstrum; delayed-onset muscle soreness; fatigue; neuromuscular electrical stimulation; spectral analysis; spectrum ID BREATHY VOCAL QUALITY; VOICE QUALITY; DYSPHONIA SEVERITY; ACOUSTIC INDEX; INDUCED INJURY; EXERCISE; WOMEN; FOLD; ELECTROMYOGRAPHY; DYSPHAGIA AB Objectives: We observed whether 30 minutes of neuromuscular electrical stimulation applied to the necks of healthy speakers would result in significant acoustic changes and perceptions of fatigue and/or delayed-onset muscle soreness (DOMS). Methods: Twelve participants were assigned to experimental (n = 6; 3 male and 3 female) and control groups (n = 6; 3 male and 3 female). Neuromuscular electrical stimulation was applied to the anterior neck in the experimental group only. All participants produced 3 trials of the vowel /a/ and the Rainbow Passage before and after completing a 30-minute phonation protocol. Recorded samples were analyzed for measures of the cepstral peak prominence, the ratio of low- to high-frequency spectral energy, and their respective standard deviations. Perceptions of fatigue and DOMS were rated on visual analog scales before, 5 minutes after, and 24 hours after completion of the phonation protocol. Results: Statistically significant acoustic findings reflecting reduced relative sound pressure level, increased high-frequency noise, and phonatory instability were observed in the experimental group. In addition, reports of fatigue and DOMS were also reported by some participants. Conclusions: A 30-minute dosage may be too high for some people experiencing neuromuscular electrical stimulation for the first time. C1 [Fowler, Linda P.] Georgia State Univ, Dept Educ Psychol & Special Educ, Atlanta, GA 30302 USA. [Gorham-Rowan, Mary] Valdosta State Univ, Dept Commun Sci & Disorders, Valdosta, GA USA. [Awan, Shaheen N.] Bloomsburg Univ Penn, Dept Audiol & Speech Language Pathol, Bloomsburg, PA 17815 USA. [Morris, Richard] Florida State Univ, Dept Commun Sci & Disorders, Tallahassee, FL 32306 USA. RP Fowler, LP (reprint author), Georgia State Univ, Dept Educ Psychol & Special Educ, POB 3979, Atlanta, GA 30302 USA. CR American College of Sports Medicine, 2006, ACSMS GUID EX TEST P, V7th ARMSTRONG RB, 1984, MED SCI SPORT EXER, V16, P529 Awan SN, 2009, J SPEECH LANG HEAR R, V52, P482, DOI 10.1044/1092-4388(2009/08-0034) Awan SN, 2010, CLIN LINGUIST PHONET, V24, P742, DOI 10.3109/02699206.2010.492446 Awan SN, 2006, CLIN LINGUIST PHONET, V20, P35, DOI 10.1080/02699200400008353 Awan SN, 2005, J VOICE, V19, P268, DOI 10.1016/j.jvoice.2004.03.005 Baken RJ, 2000, CLIN MEASUREMENT SPE, P164 Baken RJ, 2000, CLIN MEASUREMENT SPE, P172 Bemben DA, 2000, MED SCI SPORT EXER, V32, P1949, DOI 10.1097/00005768-200011000-00020 Bernthal JE, 1985, ARTICULATION PHONOLO, P224 BUCHTHAL FRITZ, 1959, QUART JOUR EXPTL PHYSIOL, V44, P137 Carding PN, 2004, CLIN OTOLARYNGOL, V29, P538, DOI 10.1111/j.1365-2273.2004.00846.x Carnaby-Mann GD, 2007, ARCH OTOLARYNGOL, V133, P564, DOI 10.1001/archotol.133.6.564 CLARKSON PM, 1992, MED SCI SPORT EXER, V24, P512 Connolly DAJ, 2003, J STRENGTH COND RES, V17, P197 Dejonckere GH, 1996, ADV CLIN PHONETICS, P217 DEKROM G, 1993, J SPEECH HEAR RES, V36, P254 ENOKA RM, 1992, J APPL PHYSIOL, V72, P1631 FAABORGANDERSEN K, 1956, NATURE, V177, P340, DOI 10.1038/177340a0 FAABORG-ANDERSEN K, 1958, Acta Otolaryngol, V49, P478, DOI 10.3109/00016485809134778 Fairbanks G., 1960, VOICE ARTICULATION D, P127 Field A., 2009, DISCOVERING STAT USI Fowler LP, 2011, J VOICE, V25, P54, DOI 10.1016/j.jvoice.2009.07.006 Goodglass H, 2000, BOSTON DIAGNOSTIC AP, V3rd Gorham-Rowan M, 2010, OPEN REHABIL J, V3, P67 Guirro Rinaldo Roberto de Jesus, 2008, Pro Fono, V20, P189, DOI 10.1590/S0104-56872008000300009 Hartl DM, 2001, J VOICE, V15, P351, DOI 10.1016/S0892-1997(01)00037-6 Heman-Ackah YD, 2002, J VOICE, V16, P20, DOI 10.1016/S0892-1997(02)00067-X HILLENBRAND J, 1994, J SPEECH HEAR RES, V37, P769 Hillenbrand J, 1996, J SPEECH HEAR RES, V39, P311 HOWELL JN, 1993, J PHYSIOL-LONDON, V464, P183 Humbert IA, 2006, J APPL PHYSIOL, V101, P1657, DOI 10.1152/japplphysiol.00348.2006 Kertesz A., 2006, W APHASIA BATTERY RE Kesar T, 2006, EXP PHYSIOL, V91, P967, DOI 10.1113/expphysiol.2006.033886 Kreiman J, 2000, J ACOUST SOC AM, V108, P1867, DOI 10.1121/1.1289362 LaGorio LA, 2010, ARCH OTOLARYNGOL, V136, P398, DOI 10.1001/archoto.2010.33 Lagorio Lisa A, 2008, Cases J, V1, P67, DOI 10.1186/1757-1626-1-67 Lieber Richard L, 2002, J Am Acad Orthop Surg, V10, P67 Ludlow CL, 2007, DYSPHAGIA, V22, P1, DOI 10.1007/s00455-006-9029-4 MACDOUGALL JD, 1985, J APPL PHYSIOL, V58, P785 MACINTYRE DL, 1995, SPORTS MED, V20, P24, DOI 10.2165/00007256-199520010-00003 Nosaka K, 2008, SKELETAL MUSCLE DAMA, P59 Ptok M, 2008, MUSCLE NERVE, V38, P1005, DOI 10.1002/mus.21063 Sanborn K, 2000, J STRENGTH COND RES, V14, P328 Sataloff RT, 2003, MUSCLE NERVE, V28, P767, DOI 10.1002/mus.10503 Shaw GY, 2007, ANN OTO RHINOL LARYN, V116, P36 SMITH LL, 1991, MED SCI SPORT EXER, V23, P542 Sulica L, 2004, OTOLARYNG CLIN N AM, V37, P59, DOI 10.1016/S0030-6665(03)00168-3 Szymanski DJ, 2001, STRENGTH COND J, V23, P7 Warren GL, 1999, SPORTS MED, V27, P43, DOI 10.2165/00007256-199927010-00004 Wijting Y, 2004, VITALSTIM THERAPY TR, P70 Wolfe VI, 2000, J SPEECH LANG HEAR R, V43, P697 NR 52 TC 1 Z9 1 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD OCT PY 2011 VL 120 IS 10 BP 641 EP 650 PG 10 WC Otorhinolaryngology SC Otorhinolaryngology GA 837MY UT WOS:000296209100003 PM 22097149 ER PT J AU Hornibrook, J George, P Spellerberg, M Gourley, J AF Hornibrook, Jeremy George, Peter Spellerberg, Myfanwy Gourley, John TI HSP70 Antibodies in 80 Patients With "Clinically Certain" Meniere's Disease SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE autoimmune hearing loss; electrocochleography; HSP70 antibody; HSP70 antigen; idiopathic progressive bilateral sensorineural hearing loss; Meniere's disease ID SENSORINEURAL HEARING-LOSS; HUMAN ENDOLYMPHATIC SAC; INNER-EAR DISEASE; SERUM ANTIBODIES; GUINEA-PIG; HEAT-SHOCK-PROTEIN-70; IMMUNOLOGY; PROTEIN; HYDROPS AB Objectives: We tested the claim that a significant proportion of patients with Meniere's disease have antibodies to heat shock protein 70 (HSP70) antigen, which may lead to defective endolymphatic sac function and vertigo attacks. Methods: Serum samples were taken from 80 subjects with a "certain" diagnosis of Meniere's disease (American Academy criteria plus electrocochleographic confirmation of endolymphatic hydrops with tone burst stimuli) and were tested for HSP70 antibodies with the OTOblot (hsp70) Western blot assay. The response was recorded as negative, positive, or equivocal. Samples from 80 sex- and age-matched blood donors were used as controls. Results: Of 80 patients with "clinically certain" Meniere's disease, 14 were positive for HSP70 antibodies or equivocal; of 80 controls, 10 were positive or equivocal. There was no significant difference (p = 0.239). There was no correlation with bilateral disease, "activity" of Meniere's disease, or stage of Meniere's disease. Conclusions: Patients with an unequivocal diagnosis of Meniere's disease do not have a significantly raised incidence of HSP70 antibodies. C1 [Hornibrook, Jeremy; Gourley, John] Christchurch Hosp, Dept Otolaryngol Head & Neck Surg & Audiol, Christchurch 8011, New Zealand. [George, Peter; Spellerberg, Myfanwy] Christchurch Hosp, Dept Clin Biochem & Immunol, Christchurch 8011, New Zealand. [Hornibrook, Jeremy] Univ Canterbury, Dept Commun Disorders, Christchurch 1, New Zealand. [George, Peter] Univ Otago, Christchurch Sch Med, Dept Pathol, Dunedin, New Zealand. RP Hornibrook, J (reprint author), Christchurch Hosp, Dept Otolaryngol Head & Neck Surg & Audiol, 2 Riccarton Ave, Christchurch 8011, New Zealand. FU Canterbury Health (Canterbury District Health Board) through the Christchurch School of Medicine FX This study was supported by a grant from Canterbury Health (Canterbury District Health Board) through the Christchurch School of Medicine. CR ALTERMATT HJ, 1990, ORL J OTO-RHINO-LARY, V52, P143 [Anonymous], 1995, OTOLARYNGOL HEAD NEC, V113, P181 Atlas MD, 1998, AM J OTOL, V19, P628 Barna BP, 1997, CLIN LAB MED, V17, P581 BLOCH DB, 1995, ARCH OTOLARYNGOL, V121, P1167 DiBerardino Federica, 2007, Int Tinnitus J, V13, P90 FUKUDA S, 1988, LARYNGOSCOPE, V98, P439 García Berrocal José Ramón, 2002, Laryngoscope, V112, P304, DOI 10.1097/00005537-200202000-00019 GIBSON WPR, 1996, AURIS NASUS LARYNX S, V23, P12 GIBSON WPR, 1993, ECOG, OAE AND INTRAOPERATIVE MONITORING, P55 HARRIS JP, 1983, OTOLARYNG HEAD NECK, V91, P18 HARRIS JP, 1984, ANN OTO RHINOL LARYN, V93, P157 HARRIS JP, 1990, LARYNGOSCOPE, V100, P516 HARRIS JP, 1987, LARYNGOSCOPE, V97, P63 Hughes G B, 1988, Laryngoscope, V98, P251 HUGHES GB, 1985, LARYNGOSCOPE, V95, P893 HUGHES GB, 1988, OTOLARYNG HEAD NECK, V98, P221 HUGHES GB, 1994, AM J OTOL, V15, P198 MCCABE BF, 1979, ANN OTO RHINOL LARYN, V88, P585 MOGI G, 1982, ARCH OTOLARYNGOL, V108, P270 MOSCICKI RA, 1994, JAMA-J AM MED ASSOC, V272, P611, DOI 10.1001/jama.272.8.611 RASKANDERSEN H, 1983, AM J OTOL, V4, P214 RASKANDERSEN H, 1991, ANN OTO RHINOL LARYN, V100, P148 RASKANDERSEN H, 1980, ACTA OTO-LARYNGOL, V89, P283, DOI 10.3109/00016488009127140 RASKANDERSEN H, 1979, ORL J OTO-RHINO-LARY, V41, P177 Rauch SD, 2000, LARYNGOSCOPE, V110, P1516, DOI 10.1097/00005537-200009000-00020 RAUCH SD, 1995, AM J OTOL, V16, P648 SALT AN, 1986, HEARING RES, V23, P141, DOI 10.1016/0378-5955(86)90011-0 Schuknecht H., 1968, OTOLARYNGOL CLIN N A, V1, P433 Shin SO, 1997, LARYNGOSCOPE, V107, P222, DOI 10.1097/00005537-199702000-00015 TOMIYAMA S, 1986, LARYNGOSCOPE, V96, P685 TOMIYAMA S, 1987, ACTA OTO-LARYNGOL, V103, P182, DOI 10.3109/00016488709107782 WACKYM PA, 1987, ANN OTO RHINOL LARYN, V96, P276 NR 33 TC 3 Z9 3 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD OCT PY 2011 VL 120 IS 10 BP 651 EP 655 PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA 837MY UT WOS:000296209100004 PM 22097150 ER PT J AU Sikand, A AF Sikand, Ashley TI Computed Tomography-Based Exploration of Infundibular Anatomy for Maxillary Sinus Balloon Dilation SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE computed tomography of sinus; sinus balloon dilation; sinus surgery ID CATHETER SINUSOTOMY; OUTCOMES; SAFETY AB Objectives: A clinically relevant reconstruction of the ethmoid infundibulum and maxillary sinus ostium was developed to use 3-dimensional computed tomographic (CT) imaging technology and measurement software in an effort to better understand the anatomy of the maxillary sinus ostium and to optimize the maxillary sinus balloon dilation technique. Methods: A retrospective review was performed of reconstructed high-resolution CT scans of patients from a private otolaryngology practice who underwent imaging for evaluation of sinus disease using multiplanar reconstruction software. The CT scans were retrospectively obtained from patients who presented for evaluation of chronic sinus disease and were analyzed with quantitative multiplanar reconstruction software that allowed measurements to be computed in clinically meaningful planes. Results: Data were obtained from 31 sinuses on 18 CT scans. The mean anteroposterior distance from the guidewire exit to the maxillary ostium was 3.5 mm, and the mean optimal guide trajectory ("clocking") angle was 17.5 degrees from the pure axial plane (95% confidence interval, 12.58 degrees to 22.48 degrees). The curvilinear guidewire travel distance was 6.9 mm from the guidewire exit to the ostial entry. Conclusions: This study reveals specific anatomic information that is applicable to the technique of transnasal maxillary sinus balloon catheter dilation. The data collected allow surgeons to anticipate the direction in which a guidewire must be manipulated in order to correctly enter the maxillary ostium. According to the data, a gentle anterior retraction of the uncinate process and a starting guide orientation 18 degrees from pure lateral will best facilitate maxillary sinus ostial access. Application of the readily available software used for this study affords the opportunity to predict the location of the natural ostium within the infundibulum before operation and customize the technique to each specific patient. C1 [Sikand, Ashley] Acclarent Inc, Menlo Pk, CA USA. RP Sikand, A (reprint author), 8530 W Sunset Rd,Suite 230, Las Vegas, NV 89113 USA. CR Bolger WE, 2006, AM J RHINOL, V20, P290, DOI 10.2500/ajr.2006.20.2868 Bolger WE, 2007, OTOLARYNG HEAD NECK, V137, P10, DOI 10.1016/j.otohns.2007.02.006 Kuhn FA, 2008, OTOLARYNG HEAD NECK, V139, pS27, DOI 10.1016/j.otohns.2008.05.010 Levine HL, 2008, ANN OTO RHINOL LARYN, V117, P263 Myerson MC, 1932, ARCHIV OTOLARYNGOL, V15, P80 Simon E, 1939, ARCHIV OTOLARYNGOL, V29, P640 Van Alyea OE, 1936, ARCHIV OTOLARYNGOL, V24, P553 NR 7 TC 4 Z9 4 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD OCT PY 2011 VL 120 IS 10 BP 656 EP 662 PG 7 WC Otorhinolaryngology SC Otorhinolaryngology GA 837MY UT WOS:000296209100005 PM 22097151 ER PT J AU Scapini, F da Silva, LFF Tsuji, DH Dolhnikoff, M Sennes, LU AF Scapini, Fabricio Ferraz da Silva, Luiz Fernando Tsuji, Domingos Hiroshi Dolhnikoff, Marisa Sennes, Luiz Ubirajara TI Effect of Fibrin Glue on Collagen Deposition After Autologous Fascia Grafting in Rabbit Vocal Folds SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE autologous fascia; collagen; fibrin glue; rabbit; vocal fold; wound healing ID SYNTHETIC EXTRACELLULAR-MATRIX; GENE-EXPRESSION; LAMINA PROPRIA; GROWTH-FACTOR; MODEL; FIBROBLASTS; INJECTION; CELLS AB Objectives: Fibrin glue (FG) is a reaction product of fibrinogen and thrombin that forms a fibrin clot responsible for tissue adhesion. However, FG and its components may interfere with wound healing by interacting with cytokines such as transforming growth factor-beta (TGF-beta). The objective of this study was to investigate the effect of FG on collagen deposition after fascia grafting in the vocal folds of rabbits. Methods: Eighteen rabbits underwent autologous fascia grafting in both vocal folds, and the left side was fixed with FG. Each animal was painlessly sacrificed after 7,30, or 90 clays. The larynx was removed, and the vocal folds were prepared for histomorphometric analysis by picrosirius red staining to evaluate collagen deposition around the graft. Results: There was a significant increase in collagen density around the grafts at 90 days in the vocal folds that were fixed with FG (p = 0.0102) compared with the control vocal folds. Conclusions: Application of FG altered collagen deposition around the fascia grafts, leading to significantly increased collagen density after 90 days. Differences found in the composition of the extracellular matrix in later stages of the healing process are a result of changes that occur in the beginning of this process. Therapeutic interventions, such as the use of FG and/or its components, performed in the early stages of wound healing may interfere with the complex interactions of fibroblasts, inflammatory cells, and cytokines (especially TGF-beta), thereby modulating the healing process. C1 [Scapini, Fabricio; Tsuji, Domingos Hiroshi; Sennes, Luiz Ubirajara] Univ Sao Paulo, Sch Med, Dept Otolaryngol, Sao Paulo, Brazil. [Ferraz da Silva, Luiz Fernando; Dolhnikoff, Marisa] Univ Sao Paulo, Sch Med, Dept Pathol, Sao Paulo, Brazil. RP Scapini, F (reprint author), Rua Ametista 175, BR-97110772 Santa Maria, RS, Brazil. RI Silva, Luiz/D-2760-2012; Sennes, Luiz/E-6815-2012 OI Silva, Luiz/0000-0002-0181-6357; FU State of Sao Paulo Research Foundation (FAPESP) FX This research was supported by the State of Sao Paulo Research Foundation (FAPESP). CR Amrani D L, 2001, Ann N Y Acad Sci, V936, P566 ARNOLD GE, 1962, ARCHIV OTOLARYNGOL, V76, P358 BENNINGER MS, 1994, OTOLARYNG HEAD NECK, V111, P497 Bhogal RK, 2005, J CLIN IMMUNOL, V25, P592, DOI 10.1007/s10875-005-7827-3 Branski RC, 2005, ANN OTO RHINOL LARYN, V114, P19 Campagnolo AM, 2010, ANN OTO RHINOL LARYN, V119, P133 Chen X, 2009, TISSUE ENG PART C-ME, V15, P201, DOI 10.1089/ten.tec.2008.0390 Cox S, 2004, TISSUE ENG, V10, P942, DOI 10.1089/1076327041348392 Duflo S, 2006, TISSUE ENG, V12, P2171, DOI 10.1089/ten.2006.12.2171 Duflo S, 2006, TISSUE ENG, V12, P3201, DOI 10.1089/ten.2006.12.3201 Ehrlich HP, 2000, SCARLESS WOUND HEALI, P99 Ford CN, 2008, LARYNGOSCOPE, V118, P1709, DOI 10.1097/MLG.0b013e31817c03c3 Gray SD, 1999, ANN OTO RHINOL LARYN, V108, P1 Hackam David J, 2002, Surg Infect (Larchmt), V3 Suppl 1, pS23, DOI 10.1089/sur.2002.3.s1-23 Hirano S, 2004, LARYNGOSCOPE, V114, P548, DOI 10.1097/00005537-200403000-00030 Horch RE, 2001, TRANSPLANT P, V33, P642, DOI 10.1016/S0041-1345(00)02181-3 Kutty JK, 2009, TISSUE ENG PART B-RE, V15, P249, DOI 10.1089/ten.TEB.2008.0588 Luo Y, 2006, TISSUE ENG, V12, P3365, DOI 10.1089/ten.2006.12.3365 NAUMANN C, 1981, LARYNG RHINOL OTOL V, V60, P364, DOI 10.1055/s-2007-1008740 Nishiyama K, 2002, ACTA OTO-LARYNGOL, V547, P72 Pryor SG, 2004, OTOLARYNGOL HEAD NEC, V131, P139 Remacle M, 2000, ANN OTO RHINOL LARYN, V109, P141 Rousseau B, 2004, J VOICE, V18, P116, DOI 10.1016/j.jvoice.2003.06.001 Rousseau B, 2008, ANN OTO RHINOL LARYN, V117, P598 Saed GM, 2004, WOUND REPAIR REGEN, V12, P557, DOI 10.1111/j.1067-1927.2004.012508.x Spotnitz William D, 2005, J Long Term Eff Med Implants, V15, P245, DOI 10.1615/JLongTermEffMedImplants.v15.i3.20 Thibeault SL, 2002, J VOICE, V16, P96, DOI 10.1016/S0892-1997(02)00078-4 Yamada Y, 2003, J CRANIO MAXILL SURG, V31, P27, DOI 10.1016/S1010-5182 NR 28 TC 2 Z9 2 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD OCT PY 2011 VL 120 IS 10 BP 663 EP 668 PG 6 WC Otorhinolaryngology SC Otorhinolaryngology GA 837MY UT WOS:000296209100006 PM 22097152 ER PT J AU Wadie, M Li, J Sasaki, CT AF Wadie, Mikhail Li, Juan Sasaki, Clarence T. TI Effect of Altered Core Body Temperature On Glottal Closing Force SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article; Proceedings Paper CT Meeting of the American-Broncho-Esophagological-Association CY APR 27-28, 2011 CL Chicago, IL SP Amer Broncho Esophagol Assoc DE glottal closing force; hyperthermia; hypothermia; sudden infant death syndrome ID SUDDEN-INFANT-DEATH; CLOSURE REFLEX; HYPERTHERMIA; MUSCLES; CAT AB Objectives: A basic function of the larynx is to provide sphincteric protection of the lower airway, initiated by a brain stem mediated glottal closure reflex. Glottal closing force is defined as the measured pressure generated between the vocal folds during glottal closure. One of the factors thought to affect the glottal closure reflex is a variation in core body temperature. Methods: Four adult male Yorkshire pigs were used in this study. The subjects were studied under control conditions (37 degrees C), hyperthermic conditions (38 degrees C to 41 degrees C), and hypothermic conditions (36 C to 34 C). Results: We demonstrated that the glottal closing force increased significantly with an increase in core body temperature and also decreased significantly with decreased core body temperature. These results are supported by neurophysiological changes demonstrated by other studies in pups and adult dogs in response to altered core body temperatures. The mechanism for these responses is thought to reside centrally, rather than in the peripheral nervous system. Conclusions: We hope that a better understanding of these aspects of glottal closure will alter the care of many patients with postanesthesia hypothermia and many sedated inmates and will also further enhance preventive measures needed to decrease the incidence of sudden infant death syndrome in overheated or febrile infants. C1 [Wadie, Mikhail; Li, Juan; Sasaki, Clarence T.] Yale Univ, Sch Med, Otolaryngol Sect, New Haven, CT 06510 USA. RP Wadie, M (reprint author), 333 Cedar St, New Haven, CT 06520 USA. CR BERGH U, 1979, ACTA PHYSIOL SCAND, V107, P33, DOI 10.1111/j.1748-1716.1979.tb06439.x BINKHORST RA, 1977, J APPL PHYSIOL, V42, P471 Fleming PJ, 1996, BRIT MED J, V313, P191 HARAGUCHI S, 1983, ANN OTO RHINOL LARYN, V92, P24 Hoyert Donna L, 2006, Natl Vital Stat Rep, V54, P1 IKARI T, 1980, ANN OTO RHINOL LARYN, V89, P220 KATZ B, 1965, J PHYSIOL-LONDON, V181, P656 KLEE MR, 1974, EXP BRAIN RES, V19, P478 Kleemann WJ, 1996, INT J LEGAL MED, V109, P139, DOI 10.1007/BF01369674 LI CL, 1977, EXP NEUROL, V55, P709, DOI 10.1016/0014-4886(77)90295-3 PETROFSKY JS, 1981, PFLUG ARCH EUR J PHY, V389, P149, DOI 10.1007/BF00582106 Pio A, 2010, PEDIATR INFECT DIS J, V29, P153, DOI 10.1097/INF.0b013e3181b4f4b0 Ponsonby AL, 1998, BRIT MED J, V316, P195 Shifrin RY, 1996, RADIOL CLIN N AM, V34, P83 TAKEUCHI NORIKO, 1958, JAPANESE JOUR PHYSIOL, V8, P391 NR 15 TC 2 Z9 2 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD OCT PY 2011 VL 120 IS 10 BP 669 EP 673 PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA 837MY UT WOS:000296209100007 PM 22097153 ER PT J AU Rutherford, KD Lerer, TS Schoem, SR Valdez, TA AF Rutherford, Kimberley D. Lerer, Trudy S. Schoem, Scott R. Valdez, Tulio A. TI Evaluation of Pediatric Sensorineural Hearing Loss: A Survey of Pediatric Otolaryngologists SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article; Proceedings Paper CT Annual Meeting of the American-Academy-of-Otolaryngology-Head-and-Neck-Surgery CY SEP 26-29, 2010 CL Boston, MA SP Amer Acad Otolaryngol Head & Neck Surg Fdn DE computed tomography; laboratory examination; magnetic resonance imaging; otology; pediatric hearing loss ID COMPUTED-TOMOGRAPHY; CHILDREN; AUTOANTIBODIES; ANTIBODIES; DIAGNOSIS AB Objectives: We sought to determine the trends in the evaluation of pediatric patients with sensorineural hearing loss (SNHL) and to determine evaluation patterns based on respondents' demographic data. Methods: All members of the American Society of Pediatric Otolaryngology were invited to voluntarily and anonymously complete an online survey. The survey was available from September 2009 to January 2010 and addressed demographic data and tests obtained in evaluating new pediatric patients with SNHL at different age points and with different degrees of hearing loss. Results: The response rate was 22.9% (79 of 345). For all ages and all types of SNHL, the most common consultations were genetics (26% to 76%) and ophthalmology (31% to 66%) consultations. Computed tomography of the temporal bones (49% to 66%), genetic testing (25% to 68%), and electrocardiography (13% to 43%) were the most commonly performed tests. Although there was no consistent difference in practice patterns by gender or years of practice, there were differences in the use of thyroid function tests, TORCH titers, and autoimmune studies by hospital affiliation. Conclusions: Type of SNHL and age are factors in the evaluation of pediatric patients with SNHL. Additionally, evaluation patterns differ according to region and hospital affiliation. The results of this study may provide guidance for otolaryngologists in making information-based and cost-effective evaluations. C1 [Rutherford, Kimberley D.; Schoem, Scott R.; Valdez, Tulio A.] Connecticut Childrens Med Ctr, Div Otolaryngol Head & Neck Surg, Hartford, CT 06106 USA. [Lerer, Trudy S.] Connecticut Childrens Med Ctr, Dept Res, Hartford, CT 06106 USA. [Rutherford, Kimberley D.] Univ Connecticut, Ctr Hlth, Div Otolaryngol Head & Neck Surg, Farmington, CT USA. RP Valdez, TA (reprint author), Connecticut Childrens Med Ctr, Div Otolaryngol Head & Neck Surg, 282 Washington St, Hartford, CT 06106 USA. CR Antonelli PJ, 1999, LARYNGOSCOPE, V109, P1642, DOI 10.1097/00005537-199910000-00018 Bonaguri C, 2007, AUTOIMMUNITY, V40, P73, DOI 10.1080/08916930601119377 Declau F, 2008, PEDIATRICS, V121, P1119, DOI 10.1542/peds.2007-1479 Duncan RD, 2007, ARCH OTOLARYNGOL, V133, P231, DOI 10.1001/archotol.133.3.231 FILLMAN RD, 1987, AM ANN DEAF, V132, P194 Grundfast Kenneth M., 1992, Ear Nose and Throat Journal, V71, P479 GRUNDFAST KM, 1992, EAR NOSE THROAT J, V71, P487 HARRIS JP, 1990, LARYNGOSCOPE, V100, P516 Hone SW, 2002, OTOLARYNG CLIN N AM, V35, P751, DOI 10.1016/S0030-6665(02)00048-8 Lalwani AK, 2002, ARCH OTOLARYNGOL, V128, P88 Mafong DD, 2002, LARYNGOSCOPE, V112, P1, DOI 10.1097/00005537-200201000-00001 Mafong DD, 2002, ARCH OTOLARYNGOL, V128, P1303 McClay JE, 2008, ARCH OTOLARYNGOL, V134, P945, DOI 10.1001/archotol.134.9.945 Morton CC, 2006, NEW ENGL J MED, V354, P2151, DOI 10.1056/NEJMra050700 Preciado DA, 2005, OTOL NEUROTOL, V26, P610, DOI 10.1097/01.mao.0000178133.89353.1d Robin NH, 2001, ARCH OTOLARYNGOL, V127, P937 Schwartz PJ, 2006, CIRCULATION, V113, P783, DOI 10.1161/CIRCULATIONAHA.105.592899 SIATKOWSKI RM, 1994, AM J OPHTHALMOL, V118, P70 Simons JP, 2006, ARCH OTOLARYNGOL, V132, P186, DOI 10.1001/archotol.132.2.186 Song JJ, 2009, OTOL NEUROTOL, V30, P604, DOI 10.1097/MAO.0b013e3181ab9185 Suslu N, 2009, LARYNGOSCOPE, V119, P341, DOI 10.1002/lary.20050 Tomaski SM, 1999, PEDIATR CLIN N AM, V46, P35, DOI 10.1016/S0031-3955(05)70079-1 NR 22 TC 3 Z9 3 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD OCT PY 2011 VL 120 IS 10 BP 674 EP 681 PG 8 WC Otorhinolaryngology SC Otorhinolaryngology GA 837MY UT WOS:000296209100008 PM 22097154 ER PT J AU Nelson, ME Griffin, GR Innis, JW Green, GE AF Nelson, Marc E. Griffin, Garrett R. Innis, Jeffrey W. Green, Glenn E. TI Campomelic Dysplasia: Airway Management in Two Patients and an Update on Clinical-Molecular Correlations in the Head and Neck SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE campomelic dysplasia; Pierre Robin syndrome; SOX9 gene; tracheobronchomalacia ID SOX9; EXPRESSION AB Campomelic dysplasia is a rare and historically lethal skeletal dysplasia with a variable but recognizable phenotype; it affects the long bones and is associated with a variety of head and neck anomalies. Mutations in or around the SOX9 gene have been identified as the molecular origin in most patients. We briefly present 2 children who meet the diagnostic criteria for campomelic dysplasia to illustrate the various clinical manifestations. Many patients with campomelic dysplasia have airway obstruction at multiple levels. We describe our approach to managing the airway in these patients, and review recent advances in understanding how SOX9 mutations lead to the spectrum of abnormalities seen in the head and neck. C1 [Nelson, Marc E.; Griffin, Garrett R.; Green, Glenn E.] Univ Michigan Hlth Syst, Dept Otolaryngol, Ann Arbor, MI USA. [Innis, Jeffrey W.] Univ Michigan Hlth Syst, Dept Pediat, Ann Arbor, MI USA. [Innis, Jeffrey W.] Univ Michigan Hlth Syst, Dept Human Genet, Ann Arbor, MI USA. RP Nelson, ME (reprint author), Akron Childrens Hosp, Pediat Ear Nose Throat Ctr, 215 W Bowery St,Suite 3200, Akron, OH 44308 USA. CR Akiyama H, 2002, GENE DEV, V16, P2813, DOI 10.1101/gad.1017802 Baldwin EL, 2008, GENET MED, V10, P415, DOI 10.1097/GIM.0b013e318177015c FOSTER JW, 1994, NATURE, V372, P525, DOI 10.1038/372525a0 Giordano J, 2001, AM J MED GENET, V98, P176, DOI 10.1002/1096-8628(20010115)98:2<176::AID-AJMG1027>3.0.CO;2-Q Gordon CT, 2009, J MED GENET, V46, P649, DOI 10.1136/jmg.2009.068361 GRAD R, 1987, PEDIATR PULM, V3, P364, DOI 10.1002/ppul.1950030514 HOUSTON CS, 1983, AM J MED GENET, V15, P3, DOI 10.1002/ajmg.1320150103 Ikonomidis C, 2010, OTOLARYNG HEAD NECK, V142, P41, DOI 10.1016/j.otohns.2009.10.024 Jakobsen LP, 2007, J MED GENET, V44, P381, DOI 10.1136/jmg.2006.046177 LEE FA, 1972, AM J DIS CHILD, V124, P485 Mansour S, 2002, J MED GENET, V39, P597, DOI 10.1136/jmg.39.8.597 MANSOUR S, 1995, J MED GENET, V32, P415, DOI 10.1136/jmg.32.6.415 Mori-Akiyama Y, 2003, P NATL ACAD SCI USA, V100, P9360, DOI 10.1073/pnas.1631288100 Nie XG, 2006, ACTA ODONTOL SCAND, V64, P97, DOI 10.1080/00016350500420089 Ruan L, 1996, INT J PEDIATR OTORHI, V37, P277, DOI 10.1016/0165-5876(96)01413-9 TAKAHASHI H, 1992, J LARYNGOL OTOL, V106, P361, DOI 10.1017/S0022215100119504 NR 16 TC 2 Z9 2 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD OCT PY 2011 VL 120 IS 10 BP 682 EP 685 PG 4 WC Otorhinolaryngology SC Otorhinolaryngology GA 837MY UT WOS:000296209100009 PM 22097155 ER PT J AU Menezes, MD McCarter, R Greene, EA Bauman, NM AF Menezes, Maithilee D. McCarter, Robert Greene, E. Anne Bauman, Nancy M. TI Status of Propranolol for Treatment of Infantile Hemangioma and Description of a Randomized Clinical Trial SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE acebutolol; hemangioma; propranolol; review ID SUBGLOTTIC HEMANGIOMA; AIRWAY HEMANGIOMAS; SPASTIC DIPLEGIA; MANAGEMENT; INFANCY; HYPOGLYCEMIA; EXPERIENCE; CHILDREN; CARE AB Objectives: Our primary objective was to review the current use of propranolol for treatment of infantile hemangioma (IH), specifically regarding 1) the age at initiation of therapy, 2) the method of initiation, 3) the use of other adjuvant therapy, 4) the duration of therapy and relapse rate, 5) the adverse events, and 6) the outcome. Our secondary objective was to describe a randomized, controlled, single-blinded trial comparing propranolol to prednisolone for treatment of IH. Methods: Ovid Medline and PubMed searches were completed for the MeSH keywords "propranolol" and "hemangioma." Forty-nine English-language articles were published between June 2008 and September 2010, and 28 of these reported data from a total of 213 patients. Only 6 studies treated more than 10 patients, and these were selected for review in detail (154 patients). Results: The treatment was initiated during infancy in 92.9% of patients (mean, 4.5 months). Sixty-five percent of patients were treated with 2 mg/kg per day, and 25.3% with 3 mg/kg per day. Patients were monitored overnight at initiation of treatment in 3 series (59 patients), for 4 to 6 hours as outpatients in 2 series (62 patients), and initially as inpatients but later as outpatients in 1 series (32 patients). Propranolol was used as sole therapy in about two thirds of patients (103 patients). Treatment was ongoing in 46% of patients at the time of publication. The average treatment duration in the remaining patients was 5.1 months. Rebound growth occurred in 21% of patients after a mean of 4.3 months of therapy. Adverse events occurred in 18.1% of patients and included hypotension in 6, somnolence in 6, wheezing in 4, insomnia, agitation, and/or nightmares in 6, cool hands or night sweats in 2, gastroesophageal reflux in 3, and psoriasis-like rash in 1. All authors reported a favorable outcome with propranolol, but the definition of efficacy was not standardized. Conclusions: Propranolol is an attractive alternative to other treatments for TH. Despite apparent widespread use of this medication, the data are limited, and prospective studies are lacking for this indication. The relatively high rate of adverse effects supports the need for careful monitoring of patients on this therapy. Fastidious reporting of adverse events and objective evaluation of early and late outcomes are necessary to improve our understanding of the use of propranolol for this indication. C1 [Bauman, Nancy M.] George Washington Univ, Dept Otolaryngol Head & Neck Surg, Childrens Natl Med Ctr, Sch Med, Washington, DC 20010 USA. [Menezes, Maithilee D.] Feldman ENT Grp, Chevy Chase, MD USA. [McCarter, Robert] George Washington Univ, Dept Biostat & Informat, Sch Med, Washington, DC 20010 USA. [Greene, E. Anne] George Washington Univ, Heart & Kidney Unit, Sch Med, Washington, DC 20010 USA. RP Bauman, NM (reprint author), George Washington Univ, Dept Otolaryngol Head & Neck Surg, Childrens Natl Med Ctr, Sch Med, 111 Michigan Ave NW, Washington, DC 20010 USA. FU NIH [5R21HD062959-02] FX Supported by NIH 5R21HD062959-02 CR [Anonymous], NCT00744185 CLINICAL [Anonymous], 2011, PHYS DESK REF [Anonymous], NCT00967226 CLINICAL ARTMAN M, 1982, PEDIATRICS, V70, P30 Barlow CF, 1998, J PEDIATR-US, V132, P527, DOI 10.1016/S0022-3476(98)70034-4 Bennett ML, 2001, ARCH DERMATOL, V137, P1208 Blanchet C, 2010, INT J PEDIATR OTORHI, V74, P959, DOI 10.1016/j.ijporl.2010.05.013 Blei F, 1999, INT PEDIAT, V14, P146 Bonifazi E, 2010, PEDIATR DERMATOL, V27, P195, DOI 10.1111/j.1525-1470.2009.01081.x Bonifazi E, 2008, EUR J PEDIAT DERMATO, V18, P185 BOWERS RE, 1960, ARCH DERMATOL, V82, P667 Breur JMPJ, 2011, PEDIATR DERMATOL, V28, P169, DOI 10.1111/j.1525-1470.2010.01224.x Bruckner AL, 2003, J AM ACAD DERMATOL, V48, P477, DOI 10.1067/mjd.2003.200 Buckmiller L, 2009, LARYNGOSCOPE, V119, P2051, DOI 10.1002/lary.20633 Buckmiller LM, 2010, LARYNGOSCOPE, V120, P676, DOI 10.1002/lary.20807 Buckmiller LM, 2009, CURR OPIN OTOLARYNGO, V17, P458, DOI 10.1097/MOO.0b013e328332a4eb Canadas KT, 2010, INT J PEDIATR OTORHI, V74, P956, DOI 10.1016/j.ijporl.2010.05.012 Chang LC, 2008, PEDIATRICS, V122, P360, DOI 10.1542/peds.2007-2767 Cheng JF, 2010, CLIN EXP OPHTHALMOL, V38, P547, DOI 10.1111/j.1442-9071.2010.02344.x Drolet BA, 1999, NEW ENGL J MED, V341, P173, DOI 10.1056/NEJM199907153410307 Enjoras O, 2004, ARCH PEDIATRIE, V11, P99, DOI 10.1016/j.arcped.2003.10.014 Enjolras O, 1997, PEDIATR DERMATOL, V14, P173, DOI 10.1111/j.1525-1470.1997.tb00232.x Fay A, 2010, ARCH OPHTHALMOL-CHIC, V128, P256, DOI 10.1001/archophthalmol.2009.375 FINN MC, 1983, J PEDIATR SURG, V18, P894 Frieden IJ, 2009, PEDIATR DERMATOL, V26, P642, DOI 10.1111/j.1525-1470.2009.00977.x Frieden IJ, 1997, J AM ACAD DERMATOL, V37, P631, DOI 10.1016/S0190-9622(97)70183-X Fulkerson DH, 2010, CHILD NERV SYST, V26, P1799, DOI 10.1007/s00381-010-1153-7 Haggstrom AN, 2006, PEDIATRICS, V118, P882, DOI 10.1542/peds.2006-0413 Holland KE, 2010, ARCH DERMATOL, V146, P775, DOI 10.1001/archdermatol.2010.158 Holmes WJM, 2010, PLAST RECONSTR SURG, V125, P420, DOI 10.1097/PRS.0b013e3181c2a731 Itani MH, 2009, BMJ CASE REPORTS, DOI [10.1136/bcr.01.2009.1476, DOI 10.1136/BCR.01.2009.1476] Kilcline C, 2008, PEDIATR DERMATOL, V25, P168, DOI 10.1111/j.1525-1470.2008.00626.x Lawley LP, 2009, PEDIATR DERMATOL, V26, P610, DOI 10.1111/j.1525-1470.2009.00975.x Leaute-Labreze C, 2008, NEW ENGL J MED, V358, P2649, DOI 10.1056/NEJMc0708819 Leboulanger N, 2010, INT J PEDIATR OTORHI, V74, P1254, DOI 10.1016/j.ijporl.2010.07.025 Li YC, 2010, CLIN EXP OPHTHALMOL, V38, P554, DOI 10.1111/j.1442-9071.2010.02327.x Manunza F, 2010, BRIT J DERMATOL, V162, P466, DOI 10.1111/j.1365-2133.2009.09597.x Marsciani A, 2010, PEDIATR BLOOD CANCER, V54, P176, DOI 10.1002/pbc.22262 Maturo S, 2010, INT J PEDIATR OTORHI, V74, P323, DOI 10.1016/j.ijporl.2009.12.008 Mazereeuw-Hautier J, 2010, J PEDIATR-US, V157, P340, DOI 10.1016/j.jpeds.2010.04.003 Melo-Gomes J A, 1993, J Rheumatol Suppl, V37, P35 Michaud AP, 2004, LARYNGOSCOPE, V114, P1231, DOI 10.1097/00005537-200407000-00017 Mistry N, 2010, J LARYNGOL OTOL, V124, P1329, DOI 10.1017/S002221511000068X Naouri M, 2010, J EUR ACAD DERMATOL, V24, P1109, DOI 10.1111/j.1468-3083.2010.03603.x Rosbe KW, 2010, ARCH OTOLARYNGOL, V136, P658, DOI 10.1001/archoto.2010.92 Sans V, 2009, PEDIATRICS, V124, pE423, DOI 10.1542/peds.2008-3458 Siegfried EC, 2008, NEW ENGL J MED, V359, P2846, DOI 10.1056/NEJMc086443 Taban Mehryar, 2010, Ophthalmology, V117, P195, DOI 10.1016/j.ophtha.2009.08.040 Tan ST, 2011, J PLAST RECONSTR AES, V64, P292, DOI 10.1016/j.bjps.2010.06.010 Theletsane T, 2009, J EUR ACAD DERMATOL, V23, P1465, DOI 10.1111/j.1468-3083.2009.03261.x Truong MT, 2010, INT J PEDIATR OTORHI, V74, P1043, DOI 10.1016/j.ijporl.2010.06.001 Vanlander A, 2010, NEONATOLOGY, V98, P229, DOI 10.1159/000291300 Wachter K, 2009, MORE DATA ADD PROPRA NR 53 TC 20 Z9 24 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD OCT PY 2011 VL 120 IS 10 BP 686 EP 695 PG 10 WC Otorhinolaryngology SC Otorhinolaryngology GA 837MY UT WOS:000296209100010 PM 22097156 ER PT J AU Burton, JN El-Deiry, MW AF Burton, Jon N. El-Deiry, Mark W. TI Use of Ultrasonic Shears in the Harvest of the Free Osteocutaneous Fibula Flap SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE fibula free flap; harmonic scalpel; head and neck cancer; microvascular reconstruction; ultrasonic shears ID FREE-TISSUE TRANSFERS; HARMONIC SCALPEL; RANDOMIZED-TRIAL; THYROID-SURGERY; RADIAL ARTERY; DISSECTION; HEAD AB Objectives: Traditionally, the fibula free flap has been raised by electrocautery and sharp dissection with clipping and tying of vessels. Use of the ultrasonic scalpel has been proposed to be a faster, more hemostatic, and less traumatic method of harvest. Methods: We performed a retrospective chart review of 58 patients who underwent fibula free flap reconstruction between 2007 and 2010. The main outcome measures were blood loss, operative time, and flap harvest time. Results: Use of the ultrasonic shears was not associated with a statistically significant reduction in intraoperative blood loss, operative time, or flap harvest time. However, the flap harvest time did trend toward statistical significance (p = 0.073). Use of distribution-based effect sizes demonstrated a moderate clinically important difference in favor of the ultrasonic shears for both operative time and flap harvest time. Conclusions: The use of ultrasonic shears is comparable to traditional methods of fibula free flap harvest and can be considered an alternative method of harvest. C1 [El-Deiry, Mark W.] H Lee Moffitt Canc Ctr & Res Inst, Head & Neck Program, FOB2 HNPROG, Tampa, FL 33612 USA. [Burton, Jon N.; El-Deiry, Mark W.] Univ S Florida, Coll Med, Dept Otolaryngol Head & Neck Surg, Tampa, FL USA. RP El-Deiry, MW (reprint author), H Lee Moffitt Canc Ctr & Res Inst, Head & Neck Program, FOB2 HNPROG, 12902 Magnolia Dr, Tampa, FL 33612 USA. CR Ahmed S, 2009, ARCH FACIAL PLAST S, V11, P343, DOI 10.1001/archfacial.2009.64 AMARAL JF, 1995, SURG LAPAROSC ENDOSC, V5, P255 Canosa C, 2007, J CARDIAC SURG, V22, P139, DOI 10.1111/j.1540-8191.2007.00374.x Cikirikcioglu M, 2001, J THORAC CARDIOV SUR, V122, P624, DOI 10.1067/mtc.2001.115690 Cohen J., 1988, STAT POWER ANAL BEHA, V2nd Deleyiannis FWB, 2007, PLAST RECONSTR SURG, V120, P157, DOI 10.1097/01.prs.0000263535.82260.f1 Deo S, 2005, PLAST RECONSTR SURG, V115, P1006, DOI 10.1097/01.PRS.0000154209.21728.51 Ecker T, 2010, OTOLARYNG HEAD NECK, V143, P17, DOI 10.1016/j.otohns.2010.03.018 Futran ND, 1998, ANN VASC SURG, V12, P445, DOI 10.1007/s100169900182 Jackson LL, 2005, LARYNGOSCOPE, V115, P1070, DOI 10.1097/01.MLG.0000163336.37077.8F Koch CA, 2011, OTOLARYNG HEAD NECK, V144, P201, DOI 10.1177/0194599810391846 Koh YW, 2008, ANN SURG, V247, P945, DOI 10.1097/SLA.0b013e31816bcd61 Lamm P, 2000, ANN THORAC SURG, V69, P1833, DOI 10.1016/S0003-4975(00)01288-1 Malata CM, 1996, PLAST RECONSTR SURG, V98, P1234, DOI 10.1097/00006534-199612000-00018 Miccoli P, 2006, ARCH OTOLARYNGOL, V132, P1069, DOI 10.1001/archotol.132.10.1069 Msika S, 2001, DIS COLON RECTUM, V44, P432, DOI 10.1007/BF02234745 Ortega J, 2004, J LAPAROENDOSC ADV A, V14, P9, DOI 10.1089/109264204322862289 Patel Anish, 2006, Interact Cardiovasc Thorac Surg, V5, P36 Pohlenz P, 2007, J CRANIO MAXILL SURG, V35, P311, DOI 10.1016/j.jcms.2007.05.001 Psacioğlu H, 1998, Ann Thorac Surg, V65, P984 Sebag F, 2009, J LAPAROENDOSC ADV S, V19, P171, DOI 10.1089/lap.2008.0043 SINGH B, 1999, PLAST RECONSTR SURG, V103, P404 Yildirim O, 2008, ADV THER, V25, P260, DOI 10.1007/s12325-008-0024-z NR 23 TC 0 Z9 0 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD SEP PY 2011 VL 120 IS 9 BP 563 EP 568 PG 6 WC Otorhinolaryngology SC Otorhinolaryngology GA 824KB UT WOS:000295199700002 PM 22032068 ER PT J AU Cho, JH Park, MS Chung, YS Hong, SC Kwon, KH Kim, JK AF Cho, Jae Hoon Park, Mun-Su Chung, Yong Soo Hong, Seok-Chan Kwon, Kui Hyang Kim, Jin Kook TI Do Anatomic Variations of the Middle Turbinate Have an Effect on Nasal Septal Deviation or Paranasal Sinusitis? SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE anatomic variation; middle turbinate; septal deviation; sinusitis ID CONCHA-BULLOSA; CT EVALUATION; DISEASE; SURGERY AB Objectives: We evaluated the relationship between 1) anatomic variations of the middle turbinate and bony septal deviations and 2) chronic sinusitis. Methods: We compared 73 computed tomographic scans of healthy control patients with 461 scans performed for evaluation of nasal symptoms. Paranasal sinusitis was identified. We recorded the incidences of anatomic variation of the middle turbinate and of bony septal deviation. Results: The incidences of anatomic variation of the middle turbinate and of bony septal deviation were not significantly different between the control group and the symptomatic group. Anatomic variation of the middle turbinate was related to contralateral septal deviation. There was no statistical relationship between bony septal deviation or middle turbinate variation and sinusitis. Conclusions: Anatomic variations of the middle turbinate have an effect on bony septal deviations to the contralateral side. However, middle turbinate variations and bony septal deviation are not associated with chronic sinusitis. C1 [Cho, Jae Hoon; Park, Mun-Su; Hong, Seok-Chan; Kim, Jin Kook] Dept Otorhinolaryngol Head & Neck Surg, Seoul, South Korea. [Kim, Jin Kook] BK21 Project Med Sci, Seoul, South Korea. [Kwon, Kui Hyang] Soonchunhyang Univ, Coll Med, Dept Radiol, Seoul, South Korea. RP Kim, JK (reprint author), Konkuk Univ, Dept Otorhinolaryngol Head & Neck Surg, Sch Med, 4-12 Hwayang Dong, Seoul 143729, South Korea. FU Konkuk University FX From the Department of Otorhinolaryngology Head and Neck Surgery (Cho, Park, Chung, Hong, Kim) and the BK21 Project for Medical Science (Kim), Konkuk University School of Medicine, and the Department of Radiology, Soonchunhyang University College of Medicine (Kwon), Seoul, Korea. This study was supported by Konkuk University (2009). CR Aktas D, 2003, RHINOLOGY, V41, P103 Arslan G, 2005, AM J NEURORADIOL, V26, P1882 Arslan G, 2005, AM J NEURORADIOL, V26, P2165 Arslan H, 1999, Auris Nasus Larynx, V26, P39, DOI 10.1016/S0385-8146(98)00024-8 BOLGER WE, 1991, LARYNGOSCOPE, V101, P56 CALHOUN KH, 1991, OTOLARYNG HEAD NECK, V104, P480 Elahi MM, 1997, J OTOLARYNGOL, V26, P236 Eweiss A, 2008, RHINOLOGY, V46, P246 Hamdan A L, 2001, J Med Liban, V49, P2 Nouraei SAR, 2009, J OTOLARYNGOL-HEAD N, V38, P32, DOI 10.2310/7070.2008.070266 Ozcan KM, 2008, J CRANIOFAC SURG, V19, P1678, DOI 10.1097/SCS.0b013e318188a29d Stallman JS, 2004, AM J NEURORADIOL, V25, P1613 Uygur K, 2003, OTOLARYNG HEAD NECK, V129, P33, DOI 10.1016/S0194-5998(03)00479-0 Yasan H, 2005, OTOLARYNG HEAD NECK, V133, P190, DOI 10.1016/j.otohns.2005.04.013 YOUSEM DM, 1991, J OTOLARYNGOL, V20, P419 NR 15 TC 7 Z9 7 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD SEP PY 2011 VL 120 IS 9 BP 569 EP 574 PG 6 WC Otorhinolaryngology SC Otorhinolaryngology GA 824KB UT WOS:000295199700003 PM 22032069 ER PT J AU D'haeseleer, E Depypere, H Claeys, S Van Lierde, KM AF D'haeseleer, Evelien Depypere, Herman Claeys, Sofie Van Lierde, Kristiane M. TI Nasal Resonance in Middle-Aged Women: A Multiparameter Approach SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article; Proceedings Paper CT 39th Annual Symposium on Care of the Professional Voice CY JUN 01-05, 2010 CL Philadelphia, PA DE aging; middle-aged woman; nasalance; Nasality Severity Index ID SPEECH PRODUCTION; PATTERNS AB Objectives: Aging influences several speech characteristics in middle-aged women. However, the effect of aging on nasal resonance has not been widely investigated, and findings are contradictory. The purpose of this study was to investigate the effect of aging on nasal resonance by comparing young women (between 20 and 28 years of age) with middle-aged women (between 45 and 55 years of age). Methods: Thirty-one middle-aged women with a mean age of 48 years participated in the subject group. The control group consisted of 22 young women with a mean age of 23 years. To investigate nasal resonance, we used a multiparameter approach by means of the Nasal Severity Index (NSI). Objective acoustic (nasal resonance scores of sounds and connected speech measured with the Nasometer) and aerodynamic measurements (maximum duration time of /s/, vital capacity, and mirror fogging test), as well as perceptual evaluations (Gutzmann /a/-/i/ test), were performed. Results: The results of this study showed no differences in aerodynamic measurements and nasal resonance scores of connected speech and the sounds /i/, /u/, and /m/. Only the mean nasal resonance score of /a/ and the Gutzmann /a/ test were significantly different between the young and middle-aged women. The mean (+/- SD) NSI scores of the young women (12.93 +/- 17.9) and the middle-aged women (-1.49 +/- 14.4) both corresponded to normal nasal resonance. Conclusions: The results of this study indicate that both young and middle-aged women show a normal nasal resonance. Differences in objective and subjective measurements of nasal resonance were only found in isolated vowels, and not in connected speech. C1 [D'haeseleer, Evelien; Claeys, Sofie; Van Lierde, Kristiane M.] Univ Ghent, Dept Otorhinolaryngol & Logoped & Audiol Sci, B-9000 Ghent, Belgium. [Depypere, Herman] Univ Ghent, Dept Urogynecol, B-9000 Ghent, Belgium. RP D'haeseleer, E (reprint author), Univ Ghent, Dept Otorhinolaryngol & Logoped & Audiol Sci, De Pintelaan 185 2Pl, B-9000 Ghent, Belgium. CR Adams D, 1991, Dent Update, V18, P14 Awan SN, 2006, CLIN LINGUIST PHONET, V20, P171, DOI 10.1080/02699200400026918 Brunnegard K, 2009, CLIN LINGUIST PHONET, V23, P58, DOI 10.1080/02699200802491074 Caruso S, 2000, FERTIL STERIL, V74, P1073, DOI 10.1016/S0015-0282(00)01582-X D'haeseleer E, 2009, MATURITAS, V64, P27, DOI 10.1016/j.maturitas.2009.06.009 D'haeseleer E, 2011, J VOICE, V25, P360, DOI 10.1016/j.jvoice.2009.10.016 Fairbanks G, 1960, VOICE ARTICULATION D Fletcher S G, 1970, Cleft Palate J, V7, P610 Foy R., 1910, ANN MAL OREILLE LARY, V36, P130 Gutzmann H., 1913, ARCH LARYNGOL RHINOL, V27, P59 Hirschberg J, 2006, INT J PEDIATR OTORHI, V70, P785, DOI 10.1016/j.ijporl.205.09.017 HOIT JD, 1994, J SPEECH HEAR RES, V37, P295 HUTCHINSON JM, 1978, J COMMUN DISORD, V11, P469, DOI 10.1016/0021-9924(78)90021-7 ISRAEL H, 1968, ARCH ORAL BIOL, V13, P133, DOI 10.1016/0003-9969(68)90044-7 JONES B, 1994, RADIOL CLIN N AM, V32, P1103 Kahane J. C., 1981, AGING COMMUNICATION, P21 LINVILLE SE, 2001, VOCAL AGING, P37 Mahne A, 2007, SEMIN NUCL MED, V37, P88, DOI 10.1053/j.semnuclmed.2006.10.003 Nishio M, 2008, FOLIA PHONIATR LOGO, V60, P120, DOI 10.1159/000118510 Van de Weijer JC, 1991, LOGOP FONIATR, V63, P97 Van den Broecke M. P. R., 1988, TER SPRAKE, P400 Van Lierde K, 2003, SCAND J PLAST RECONS, V37, P344, DOI 10.1080/02844310310004307 Van Lierde KM, 2007, FOLIA PHONIATR LOGO, V59, P31, DOI 10.1159/00096548 Xue SA, 2003, J SPEECH LANG HEAR R, V46, P689, DOI 10.1044/1092-4388(2003/054) NR 24 TC 0 Z9 0 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD SEP PY 2011 VL 120 IS 9 BP 575 EP 580 PG 6 WC Otorhinolaryngology SC Otorhinolaryngology GA 824KB UT WOS:000295199700004 PM 22032070 ER PT J AU Felippu, A AF Felippu, Alexandre TI Nasal Centripetal Endoscopic Sinus Surgery SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE centripetal technique; endoscope; ethmoid sinus surgery; microscope ID COMPLICATIONS; MANAGEMENT AB Objectives: My aim in this article is to report 26 years of experience in order to evaluate the applicability and efficiency of centripetal dissection in intranasal ethmoid sinus surgery. Methods: I performed a retrospective review of 2,500 patients treated in the Felippu Institute, Sao Paulo, over the 26-year period from 1984 to July 2010. All of the patients underwent intranasal ethmoid sinus surgery with the centripetal technique. Before surgery, an otolaryngological examination, nasal endoscopy, and computed tomographic scans with axial, coronal, and sagittal projections were performed. All surgeries were carried out under general anesthesia and with the help of a surgical microscope or (after 1997) a rigid 30 endoscope. The surgical technique required a standard endoscopic sinus surgery set. The complications of intranasal ethmoid sinus surgery were recorded and classified as intraoperative, short-term, or long-term. Results: I observed an intraoperative complication (cerebrospinal fluid leak) in 4 patients. There were no cases of peri-orbital damage. I recorded no short-term or long-term complications. All of the intraoperative complications were resolved during surgery. Conclusions: With the use of this technique, the surgeon can precisely identify the position of the surgical instrument without losing his or her orientation, and thereby significantly reduce the risk of complications. C1 [Felippu, Alexandre] Felippu Inst, Sao Paulo, Brazil. RP Felippu, A (reprint author), Rua Stela Marina 46, BR-04601090 Sao Paulo, Brazil. CR Becker SS, 2009, OTOLARYNG CLIN N AM, V42, P377, DOI 10.1016/j.otc.2009.01.002 Bisdas S, 2004, J COMPUT ASSIST TOMO, V28, P661, DOI 10.1097/01.rct.0000134198.12043.42 Cassano M, 2009, RHINOLOGY, V47, P362, DOI 10.4193/Rhin08.175 Chu Sau-Tung, 2006, J Chin Med Assoc, V69, P529 CUMBERWORTH VL, 1994, CLIN OTOLARYNGOL, V19, P248, DOI 10.1111/j.1365-2273.1994.tb01225.x Ecevit MC, 2008, J OTOLARYNGOL-HEAD N, V37, P160, DOI 10.2310/7070.2008.0030 Emmez H, 2009, ACTA NEUROCHIR, V151, P1001, DOI 10.1007/s00701-009-0347-9 Han JK, 2010, CURR OPIN OTOLARYNGO, V18, P32, DOI 10.1097/MOO.0b013e328334a9f1 HEERMANN H, 1958, Arch Ohren Nasen Kehlkopfheilkd, V171, P295, DOI 10.1007/BF02127286 ILIEVA K, 2008, B SOC BELGE OPHTALMO, V308, P9 Keerl R, 1999, LARYNGOSCOPE, V109, P546, DOI 10.1097/00005537-199904000-00005 KENNEDY DW, 1985, ARCH OTOLARYNGOL, V111, P643 KENNEDY DW, 1994, OTOLARYNG HEAD NECK, V111, P589, DOI 10.1016/S0194-5998(94)70526-7 MOSHER HARRIS P., 1929, ANN OTOL RHINOL & LARYNGOL, V38, P869 Patel ZM, 2010, OTOLARYNG CLIN N AM, V43, P855, DOI 10.1016/j.otc.2010.04.010 Schipper J, 2004, LARYNGO RHINO OTOL, V83, P298, DOI 10.1055/s-2004-814362 Socher JA, 2008, ACTA OTO-LARYNGOL, V128, P1004, DOI 10.1080/00016480701793735 STAMMBERGER H, 1984, LARYNG RHINOL OTOL V, V63, P48, DOI 10.1055/s-2007-1008240 Stankiewicz JA, 2004, AM J RHINOL, V18, P35 Ulualp SO, 2008, CURR OPIN OTOLARYNGO, V16, P252, DOI 10.1097/MOO.0b013e3282fdc3b2 NR 20 TC 2 Z9 4 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD SEP PY 2011 VL 120 IS 9 BP 581 EP 585 PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA 824KB UT WOS:000295199700005 PM 22032071 ER PT J AU Guven, DG Demiraran, Y Sezen, G Kepek, O Iskender, A AF Guven, Damla Guclu Demiraran, Yavuz Sezen, Gulbin Kepek, Okkes Iskender, Abdulkadir TI Evaluation of Outcomes in Patients Given Dexmedetomidine in Functional Endoscopic Sinus Surgery SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE dexmedetomidine; FESS; functional endoscopic sinus surgery; hemodynamic stability; intraoperative bleeding ID CONTROLLED HYPOTENSION; SODIUM-NITROPRUSSIDE; ANALGESIA; SEDATION; AGONISTS AB Objectives: We aimed to evaluate the effects of dexmedetomidine hydrochloride (DEX) on hemodynamic parameters and on surgeon and patient satisfaction during functional endoscopic sinus surgery (FESS). Methods: Forty patients who were to undergo FESS were enrolled in this randomized, prospective, controlled study. In the DEX group, conscious sedation was induced with an infusion of 1 mu g/kg of DEX 10 minutes before surgery, followed by an infusion of DEX at 0.2 mu g/kg per hour. A control group was given identical amounts of saline solution. During the procedure, hemodynamic data were recorded. The patients evaluated their pain on a visual analog scale (VAS). Intraoperative bleeding was rated on a 6-point scale for evaluation of operative field visibility. Results: We observed that the DEX group had lower bleeding scores (p = 0.019). The heart rates were lower in the DEX group at the time of induction (p = 0.052) and in the 1st (p = 0.009) and 20th minutes (p = 0.039) of induction. The mean blood pressure values were lower in the DEX group in the 5th (p < 0.001), 45th (p = 0.003), and 60th (p = 0.05) minutes of induction. The VAS score was lower in the DEX group in the 30th postoperative minute (p = 0.001); however, the VAS score was lower in the control group after the 12th hour (p < 0.001). Postoperative side effects such as nausea, tachycardia, hypotension, and vomiting were significantly less frequent in the DEX group (p < 0.001). Conclusions: We observed that the intraoperative bleeding, hemodynamic stability, and VAS scores were better and the side effects were less frequent in the DEX group. C1 [Guven, Damla Guclu] Duzce Univ, Sch Med, Dept Otorhinolaryngol, Konuralp, Duzce, Turkey. [Demiraran, Yavuz; Sezen, Gulbin; Kepek, Okkes; Iskender, Abdulkadir] Duzce Univ, Sch Med, Dept Anesthesiol, Konuralp, Duzce, Turkey. RP Guven, DG (reprint author), Duzce Univ, Sch Med, Dept Otorhinolaryngol, Konuralp, Duzce, Turkey. CR Al-Metwalli RR, 2008, BRIT J ANAESTH, V101, P395, DOI 10.1093/bja/aen184 Ayoglu H, 2008, J CLIN ANESTH, V20, P437, DOI 10.1016/j.jclinane.2008.04.008 BOEZAART AP, 1995, CAN J ANAESTH, V42, P373 Cincikas Darius, 2003, Medicina (Kaunas), V39, P852 Demiraran Y, 2007, CAN J GASTROENTEROL, V21, P25 Easley RB, 2009, INDIAN PEDIATR, V46, P761 Ebert TJ, 2000, ANESTHESIOLOGY, V93, P382, DOI 10.1097/00000542-200008000-00016 FROMME GA, 1986, ANESTH ANALG, V65, P683 Goksu S, 2008, EUR J ANAESTH, V25, P22, DOI 10.1017/S0265021507001317 Jacobi KE, 2000, J CLIN ANESTH, V12, P202, DOI 10.1016/S0952-8180(00)00145-8 Kamibayashi T, 2000, ANESTHESIOLOGY, V93, P1345, DOI 10.1097/00000542-200011000-00030 KENNEDY DW, 1985, ARCH OTOLARYNGOL, V111, P576 Lin TF, 2009, BRIT J ANAESTH, V102, P117, DOI 10.1093/bja/aen320 Ragab SM, 2010, OTOLARYNG HEAD NECK, V142, P48, DOI 10.1016/j.otohns.2009.10.021 REVES JG, 2009, MILLERS ANESTHESIA, V1, P751 Wijeysundera DN, 2003, AM J MED, V114, P742, DOI 10.1016/S0002-9343(03)00165-7 NR 16 TC 4 Z9 4 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD SEP PY 2011 VL 120 IS 9 BP 586 EP 592 PG 7 WC Otorhinolaryngology SC Otorhinolaryngology GA 824KB UT WOS:000295199700006 PM 22032072 ER PT J AU Cashman, EC MacMahon, PJ Shelly, MJ Kavanagh, EC AF Cashman, Emma C. MacMahon, Peter J. Shelly, Martin J. Kavanagh, Eoin C. TI Role of Positron Emission Tomography- Computed Tomography in Head and Neck Cancer SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE computed tomography; head and neck cancer; positron emission tomography ID SQUAMOUS-CELL-CARCINOMA; LYMPH-NODE METASTASES; UNKNOWN PRIMARY TUMOR; STAGE-IV HEAD; DISTANT METASTASES; NASOPHARYNGEAL CARCINOMA; F-18-FDG PET/CT; FDG-PET; RADIATION TREATMENT; THYROID-CARCINOMA AB Head and neck squamous cell carcinoma (HNC) is the sixth most common cancer worldwide. In the United States, it accounts for approximately 2% of all cancers and 2% of cancer deaths. The introduction of integrated positron emission tomography and computed tomography (PET/CT) has revolutionized imaging by permitting improved and more accurate anatomic localization of functional abnormalities in the complex territory of the head and neck region, and PET/CT has become a standard clinical imaging modality in patients with HNC. The main indications for PET/CT in HNC are in pretherapy staging, detection of unknown primaries, and monitoring of therapy response or disease surveillance. Although PET/CT is a promising tool in diagnosis and surveillance of HNC, there is lack of consensus as to its use, accuracy, and implications for patient management. The existing literature on the role of PET/CT in the management of HNC is reviewed, and a summary of the current debate is provided. Second primary cancers are the main cause of death among HNC patients with early disease, and the presence of distant metastases greatly impairs the survival of patients with advanced HNC. Therefore, early detection of second primary and metastatic tumors is imperative for optimizing survival outcome. However, given the lack of randomized, prospective trials addressing the role of PET/CT after chemoradiotherapy, the ideal function of PET/CT in disease surveillance has yet to be defined. C1 [Cashman, Emma C.] Dana Farber Canc Inst, Boston, MA 02115 USA. [MacMahon, Peter J.; Shelly, Martin J.; Kavanagh, Eoin C.] Mater Misericordiae Univ Hosp, Dept Radiol, Dublin, Ireland. RP Cashman, EC (reprint author), 92 Beacon St, Boston, MA 02108 USA. CR Adams S, 1998, EUR J NUCL MED, V25, P1255, DOI 10.1007/s002590050293 Agarwal V, 2008, OTOLARYNG CLIN N AM, V41, P23, DOI 10.1016/j.otc.2007.10.005 AGARWAL V, 2008, OTOLARYNGOL CLIN N A, V41, pR5 Brouwer J, 2005, LARYNGOSCOPE, V115, P1813, DOI 10.1097/01.mlg.0000174954.51541.b7 Brouwer J, 2006, ORAL ONCOL, V42, P275, DOI 10.1016/j.oraloncology.2005.07.009 BRYCE DP, 1963, ANN OTO RHINOL LARYN, V72, P416 BRYCE DP, 1971, LARYNGOSCOPE, V81, P1481, DOI 10.1288/00005537-197109000-00012 Castelijns JA, 2002, EUR RADIOL, V12, P727, DOI 10.1007/s003300101102 Castelijns JA, 2001, AM J NEURORADIOL, V22, P3 Chen YK, 2006, ANTICANCER RES, V26, P1471 Chua MLK, 2009, HEAD NECK-J SCI SPEC, V31, P346, DOI 10.1002/hed.20974 Curtin HD, 1998, RADIOLOGY, V207, P123 Erkal HS, 2001, J CLIN ONCOL, V19, P1358 FEINMESSER R, 1992, HEAD NECK-J SCI SPEC, V14, P173, DOI 10.1002/hed.2880140302 Ferlito A, 2003, ORAL ONCOL, V39, P429, DOI 10.1016/S1368-8375(02)00010-1 Fogarty GB, 2003, HEAD NECK-J SCI SPEC, V25, P138, DOI 10.1002/hed.10191 Goodwin WJ, 2000, LARYNGOSCOPE, V110, P1, DOI 10.1097/00005537-200003001-00001 Gourin CG, 2006, LARYNGOSCOPE, V116, P705, DOI 10.1097/01.MLG.0000215176.98582.A9 Gourin CG, 2008, LARYNGOSCOPE, V118, P671, DOI 10.1097/MLG.0b013e3181625737 Hao SP, 2000, OTOLARYNG HEAD NECK, V123, P324, DOI 10.1067/mhn.2000.105252 Heron DE, 2004, INT J RADIAT ONCOL, V60, P1419, DOI 10.1016/j.ijrobp.2004.05.037 Hunter KD, 2005, NAT REV CANCER, V5, P127, DOI 10.1038/nrc1549 Ito K, 2010, EUR J NUCL MED MOL I, V37, P1318, DOI 10.1007/s00259-010-1400-x Jemal A, 2005, CA-CANCER J CLIN, V55, P10 Jemal A, 2008, CA-CANCER J CLIN, V58, P71, DOI 10.3322/CA.2007.0010 JOVANOVIC A, 1994, ORAL ONCOL, V30B, P225 KELLER F, HEAD NECK IN PRESS Kim SY, 2007, ANN ONCOL, V18, P1698, DOI 10.1093/annonc/mdm270 Krabbe CA, 2009, ORAL ONCOL, V45, P234, DOI 10.1016/j.oraloncology.2008.05.024 Kunkel M, 2003, ORAL ONCOL, V39, P170, DOI 10.1016/S1368-8375(02)00087-8 Kunkel M, 2006, ORAL ONCOL, V42, P297, DOI 10.1016/j.oraloncology.2005.08.004 Kyzas PA, 2008, J NATL CANCER I, V100, P712, DOI 10.1093/jnci/djn125 LAPELA M, 1995, RADIOLOGY, V197, P205 Liu FY, 2007, J NUCL MED, V48, P1614, DOI 10.2967/jnumed.107.043406 Lonneux M, 2010, J CLIN ONCOL, V28, P1190, DOI 10.1200/JCO.2009.24.6298 Lowe VJ, 1997, HEAD NECK-J SCI SPEC, V19, P666, DOI 10.1002/(SICI)1097-0347(199712)19:8<666::AID-HED4>3.0.CO;2-3 Myers LL, 1998, LARYNGOSCOPE, V108, P232, DOI 10.1097/00005537-199802000-00014 Nakamoto Y, 2005, RADIOLOGY, V234, P879, DOI 10.1148/radiol.2343030301 National Comprehensive Cancer Network, NCCN CLIN PRACT GUID Nayak JV, 2007, LARYNGOSCOPE, V117, P2129, DOI 10.1097/MLG.0b013e318149e6be Ng SH, 2009, EUR J NUCL MED MOL I, V36, P538, DOI 10.1007/s00259-009-1080-6 Ng SH, 2009, EUR RADIOL, V19, P2965, DOI 10.1007/s00330-009-1504-5 Ng SH, 2009, EUR J NUCL MED MOL I, V36, P12, DOI 10.1007/s00259-008-0918-7 Ng SH, 2008, NEURORADIOLOGY, V50, P969, DOI 10.1007/s00234-008-0426-2 O'Neill JP, 2010, J LARYNGOL OTOL, V124, P1274, DOI 10.1017/S0022215110001398 Ong SC, 2008, J NUCL MED, V49, P532, DOI 10.2967/jnumed.107.044792 PARSONS JT, 1988, INT J RADIAT ONCOL, V14, P649 Paul SAM, 2007, EUR ARCH OTO-RHINO-L, V264, P189, DOI 10.1007/s00405-006-0177-9 Pohar S, 2007, INT J RADIAT ONCOL, V68, P383, DOI 10.1016/j.ijrobp.2006.12.044 Quon A, 2007, J NUCL MED, V48, p58S Rabalais AG, 2009, LARYNGOSCOPE, V119, P1120, DOI 10.1002/lary.20201 REGE S, 1994, CANCER, V73, P3047, DOI 10.1002/1097-0142(19940615)73:12<3047::AID-CNCR2820731225>3.0.CO;2-# Roh JL, 2007, ORAL ONCOL, V43, P887, DOI 10.1016/j.oratoncotogy.2006.10.011 Rusthoven KE, 2004, CANCER, V101, P2641, DOI 10.1002/cncr.20687 Schmid DT, 2003, LARYNGOSCOPE, V113, P888, DOI 10.1097/00005537-200305000-00021 Schoder H, 2006, J NUCL MED, V47, P755 Schoder H, 2004, SEMIN NUCL MED, V34, P180, DOI 10.1053/j.semnuclmed.2004.03.004 Schoder H, 2009, J NUCL MED, V50, p74S, DOI 10.2967/jnumed.108.057208 SCHWARTZ LH, 1994, CANCER, V74, P1933, DOI 10.1002/1097-0142(19941001)74:7<1933::AID-CNCR2820740718>3.0.CO;2-X SOM PM, 1992, AM J ROENTGENOL, V158, P961 STERN WBR, 1990, HEAD NECK-J SCI SPEC, V12, P109, DOI 10.1002/hed.2880120203 Stoeckli SJ, 2002, HEAD NECK-J SCI SPEC, V24, P345, DOI 10.1002/hed.10057 Stokkel MPM, 1999, CANCER, V86, P2370, DOI 10.1002/(SICI)1097-0142(19991201)86:11<2370::AID-CNCR27>3.0.CO;2-B Syed R, 2005, BRIT J CANCER, V92, P1046, DOI 10.1038/sj.bjc.6602464 Tan A, 2007, ARCH OTOLARYNGOL, V133, P435, DOI 10.1001/archotol.133.5.435 Teknos TN, 2001, HEAD NECK-J SCI SPEC, V23, P1056, DOI 10.1002/hed.10006 Veit-Haibach P, 2007, EUR J NUCL MED MOL I, V34, P1953, DOI 10.1007/s00259-007-0564-5 Wong WL, 1997, CLIN OTOLARYNGOL, V22, P209, DOI 10.1046/j.1365-2273.1997.00852.x Xie P, 2010, J CANCER RES CLIN, V136, P883, DOI 10.1007/s00432-009-0729-7 Xie P, 2011, J CANCER RES CLIN, V137, P1085, DOI 10.1007/s00432-010-0972-y Yao M, 2009, INT J RADIAT ONCOL, V74, P9, DOI 10.1016/j.ijrobp.2008.07.019 Yao M, 2005, INT J RADIAT ONCOL, V63, P991, DOI 10.1016/j.ijrobp.2005.03.066 Yen RF, 2005, J NUCL MED, V46, P770 Yen TC, 2006, INT J RADIAT ONCOL, V65, P1307, DOI 10.1016/j.ijrobp.2006.02.031 Yoshida K, 2009, EUR J NUCL MED MOL I, V36, P1417, DOI 10.1007/s00259-009-1127-8 Zimmer LA, 2005, LARYNGOSCOPE, V115, P2029, DOI 10.1097/01.MLG.0000181495.94611.A6 NR 76 TC 5 Z9 5 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD SEP PY 2011 VL 120 IS 9 BP 593 EP 602 PG 10 WC Otorhinolaryngology SC Otorhinolaryngology GA 824KB UT WOS:000295199700007 PM 22032073 ER PT J AU Zeitels, SM Burns, JA Wain, JC Wright, CD Rosenberg, AE AF Zeitels, Steven M. Burns, James A. Wain, John C. Wright, Cameron D. Rosenberg, Andrew E. TI Function Preservation Surgery in Patients With Chondrosarcoma of the Cricoid Cartilage SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article; Proceedings Paper CT Meeting of the American-Broncho-Esophagological-Association CY APR 27-28, 2011 CL Chicago, IL SP Amer Broncho Esophagol Assoc DE chondrosarcoma; cricoid cartilage; laryngeal cancer; larynx; partial laryngectomy; subglottic reconstruction; subglottic tumor ID LARYNX; TUMORS AB Chondrosarcoma is a rare laryngeal neoplasm that is most commonly encountered in the cricoid cartilage and is optimally treated by surgical excision. It is typically a slow-growing malignancy with well-defined margins and a minimal risk of metastasis; however, radiographic imaging studies often appear ominous if the clinician correlates these findings to the biological behavior of epithelial cancer. Furthermore, the fact that the neoplasm's epicenter is usually under the cricoarytenoid joint can lead to airway and voice deficits before and after operation. Although many surgeons opt for function-sparing resection approaches, it is commonplace for some surgeons to injudiciously perform total laryngectomy as the initial treatment because of the rarity, large size, location, and appearance of these tumors on imaging studies. A retrospective review was done on 10 cases of cricoid chondrosarcoma to gain insight into the treatment strategies designed to preserve laryngeal function while minimizing the risk of local recurrence. We performed surgical resection in 8 of the 10 patients; 2 underwent endoscopic removal and 6 underwent transcervical partial laryngectomy. All are free of disease with good voice and swallowing function. One patient developed a limited recurrence and required a second transcervical partial laryngectomy. Function-sparing surgical treatment of chondrosarcomas of the cricoid cartilage can usually be achieved. Surgeons should carefully modify the core principles of epithelial cancer surgery techniques, adjusting to the different biological behavior of laryngeal chondrosarcomas. C1 [Zeitels, Steven M.; Burns, James A.] Massachusetts Gen Hosp, Ctr Laryngeal Surg & Voice Rehabil, Boston, MA 02114 USA. [Zeitels, Steven M.; Burns, James A.; Wain, John C.; Wright, Cameron D.] Harvard Univ, Sch Med, Dept Surg, Cambridge, MA 02138 USA. [Rosenberg, Andrew E.] Harvard Univ, Sch Med, Dept Pathol, Cambridge, MA 02138 USA. [Wain, John C.; Wright, Cameron D.] Massachusetts Gen Hosp, Div Thorac Surg, Boston, MA 02114 USA. [Rosenberg, Andrew E.] Massachusetts Gen Hosp, Dept Pathol, Boston, MA 02114 USA. RP Zeitels, SM (reprint author), Massachusetts Gen Hosp, Ctr Laryngeal Surg & Voice Rehabil, 1 Bowdoin Sq, Boston, MA 02114 USA. CR BATSAKIS JG, 1984, TUMORS HEAD NECK CLI, P219 BRANDWEIN M, 1992, LARYNGOSCOPE, V102, P858, DOI 10.1288/00005537-199208000-00004 Gaissert HA, 2005, J THORAC CARDIOV SUR, V129, P1006, DOI 10.1016/j.jtcvs.2004.07.043 Hoffman HT, 2006, LARYNGOSCOPE, V116, P1, DOI 10.1097/01.mlg.0000236095.97947.26 HYAMS VJ, 1970, LARYNGOSCOPE, V80, P755 Koufman JA, 2004, LARYNGOSCOPE, V114, P1529, DOI 10.1097/00005537-200409000-00004 Lewis JE, 1997, ANN OTO RHINOL LARYN, V106, P94 Thompson LDR, 2002, AM J SURG PATHOL, V26, P836, DOI 10.1097/00000478-200207000-00002 Wurtz A, 2006, NEW ENGL J MED, V355, P1938, DOI 10.1056/NEJMc066336 ZEITELS SM, 1994, ANN OTO RHINOL LARYN, V103, P669 Zeitels SM, 2004, ANN OTO RHINOL LARYN, V113, P16 NR 11 TC 6 Z9 6 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD SEP PY 2011 VL 120 IS 9 BP 603 EP 607 PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA 824KB UT WOS:000295199700008 PM 22032074 ER PT J AU Redfors, YD Moller, C AF Redfors, Ylva Dahlin Moller, Claes TI Otosclerosis: Thirty-Year Follow-Up After Surgery SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE hearing threshold; long-term follow-up; otosclerosis; sensorineural hearing loss; stapedectomy ID SENSORINEURAL HEARING-LOSS; STAPEDIAL OTOSCLEROSIS; COCHLEAR OTOSCLEROSIS; STAPEDECTOMY; STAPEDOTOMY; LOCUS; TERM; MAPS; IMPROVEMENT; COMPONENT AB Objectives: The aims of this study were to evaluate the hearing outcomes 28 to 30 years after stapedectomy in patients with surgically confirmed otosclerosis, and to evaluate inner ear involvement. Methods: A retrospective clinical study was performed. Sixty-five consecutive patients who underwent stapedectomy at a tertiary referral center between 1977 and 1979 were included in the study. Medical records, including preoperative and postoperative audiograms, were reviewed, and a long-term follow-up clinical examination and pure tone audiometry were performed. The hearing outcome was compared with that of a reference population (ISO 7029) in terms of age and gender. Results: Thirty years after stapedectomy, 66% of the patients' ears studied showed a moderate to profound hearing loss. The deterioration was mainly caused by a sensory hearing loss. The hearing loss was significantly greater than that in the reference population for both air and bone conduction thresholds at the early and late stages of the disease. A large majority of the patients (88%) had bilateral otosclerosis. Conclusions: Patients with otosclerosis have a sensorineural hearing loss that cannot be explained by age. Otosclerosis should be regarded as a middle and inner ear disease. Almost all patients with otosclerosis are in need of ongoing audiological rehabilitation and hearing aids. C1 [Redfors, Ylva Dahlin] Univ Gothenburg, Sahlgrenska Acad, Dept Clin Sci, Dept Otolaryngol, SE-41345 Gothenburg, Sweden. [Moller, Claes] Univ Orebro, Orebro Univ Hosp, Dept Audiol, Swedish Inst Disabil Res,Sch Hlth Sci, Orebro, Sweden. RP Redfors, YD (reprint author), Univ Gothenburg, Sahlgrenska Acad, Dept Clin Sci, Dept Otolaryngol, Grona St 9, SE-41345 Gothenburg, Sweden. CR Aarnisalo AA, 2003, OTOL NEUROTOL, V24, P567, DOI 10.1097/00129492-200307000-00006 Ali IBH, 2008, HUM GENET, V123, P267, DOI 10.1007/s00439-008-0470-3 [Anonymous], 2000, 7029 ISO [Anonymous], 1995, OTOLARYNGOL HEAD NEC, V113, P186 Arlinger S., 2007, NORDISK LAROBOK AUDI, P192 BIRCH L, 1986, J LARYNGOL OTOL, V100, P1 BROWNING GG, 1984, ANN OTO RHINOL LARYN, V93, P13 Brownstein Z, 2006, ARCH OTOLARYNGOL, V132, P416, DOI 10.1001/archotol.132.4.416 CARHART R, 1950, ARCH OTOLARYNGOL, V51, P798 Chen W, 2002, J MED GENET, V39, P473, DOI 10.1136/jmg.39.7.473 Declau F, 2001, OTOL NEUROTOL, V22, P596, DOI 10.1097/00129492-200109000-00006 Fisch U, 2009, OTOL NEUROTOL, V30, P1160, DOI 10.1097/MAO.0b013e3181c1792d Karhuketo TS, 2007, ORL J OTO-RHINO-LARY, V69, P322, DOI 10.1159/000107672 KARJALAINEN S, 1984, J LARYNGOL OTOL, V98, P255, DOI 10.1017/S0022215100146523 Kos MI, 2001, ANN OTO RHINOL LARYN, V110, P907 KURSTEN R, 1994, AM J OTOL, V15, P804 LARSSON A, 1960, Acta Otolaryngol Suppl, V154, P1 Lippy WH, 2005, LARYNGOSCOPE, V115, P1833, DOI 10.1097/01.MLG.0000187573.99335.85 Lolov S, 2007, ADV OTO-RHINO-LARYNG, V65, P107, DOI 10.1159/000098678 MCKENNA MJ, 1986, AM J OTOL, V7, P25 Mudry A, 2006, OTOL NEUROTOL, V27, P276, DOI 10.1097/01.mao.0000187050.04286.80 Nelson EG, 2004, LARYNGOSCOPE, V114, P1214, DOI 10.1097/00005537-200407000-00016 Persson P, 1997, ACTA OTO-LARYNGOL, V117, P94, DOI 10.3109/00016489709117998 PIRODDA E, 1995, ACTA OTO-LARYNGOL, V115, P427, DOI 10.3109/00016489509139342 Ramsay H, 1997, AM J OTOLARYNG, V18, P23, DOI 10.1016/S0196-0709(97)90044-2 RAMSAY HAW, 1994, AM J OTOL, V15, P536 SCHUKNEC.HF, 1974, LARYNGOSCOPE, V84, P766, DOI 10.1288/00005537-197405000-00008 SHEA J J Jr, 1958, Ann Otol Rhinol Laryngol, V67, P932 Spandow O, 2000, SCAND AUDIOL, V29, P186, DOI 10.1080/010503900750042752 Thys M, 2007, EUR J HUM GENET, V15, P362, DOI 10.1038/sj.ejhg.5201761 Tomek MS, 1998, HUM MOL GENET, V7, P285, DOI 10.1093/hmg/7.2.285 Topsakal V, 2006, OTOL NEUROTOL, V27, P781, DOI 10.1097/01.mao.0000231500.46534.79 Uppal S, 2010, INT J CLIN PRACT, V64, P256, DOI 10.1111/j.1742-1241.2009.02046.x Van Den Bogaert K, 2004, J MED GENET, V41, P450, DOI 10.1136/jmg.2004.018671 Van den Bogaert K, 2001, AM J HUM GENET, V68, P495, DOI 10.1086/318185 WILLIS R, 1989, OTOLARYNG HEAD NECK, V100, P224 YOO TJ, 1983, ANN OTO RHINOL LARYN, V92, P103 NR 37 TC 8 Z9 8 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD SEP PY 2011 VL 120 IS 9 BP 608 EP 614 PG 7 WC Otorhinolaryngology SC Otorhinolaryngology GA 824KB UT WOS:000295199700009 PM 22032075 ER PT J AU Zhang, Q Wei, JR Xu, M Zhang, QA Zhang, XT Zhang, ZB Dang, SN Huang, XS Anniko, M Hellstrom, S Duan, ML AF Zhang, Qing Wei, Junrong Xu, Min Zhang, Quanan Zhang, Xiaotong Zhang, Zhibao Dang, Shaonong Huang, Xinsheng Anniko, Matti Hellstrom, Sten Duan, Maoli TI Prevalence of Otitis Media With Effusion Among Children in Xi'an, China: A Randomized Survey in China's Mainland SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE epidemiology; otitis media with effusion; prevalence; screening; tympanometry ID POINT PREVALENCE; SECRETORY OTITIS; RISK-FACTORS; SCHOOLCHILDREN AB Objectives: We sought to identify the prevalence of otitis media with effusion (OME) in urban Chinese children in Xi'an, China. Methods: Five kindergartens and 3 primary schools were randomly selected in the urban area of Xi'an. Screening otoscopic and tympanometric examinations were performed on 2,902 children (1,491 boys and 1,411 girls) 2 to 8 years of age. Children with an abnormal tympanogram and simultaneous otomicroscopic signs of effusion were given a diagnosis of OME. Results: The overall prevalence of OME was 4.3%. By age group, the prevalence was 14.0% in 2-year-olds, 8.3% in 3-year-olds, 5.0% in 4-year-olds, 4.9% in 5-year-olds, 2.8% in 6-year-olds, 1.7% in 7-year-olds, and 3.2% in 8-year-olds. The prevalence rate for OME was 4.7% for boys versus 3.9% for girls, and 3.0% in the right ear versus 2.7% in the left, showing no statistically significant difference between genders or between ear sides (p > 0.05). Conclusions: The prevalence of OME in urban areas of Xi'an is not high in comparison with that of the same age group in surrounding areas. C1 [Zhang, Qing; Wei, Junrong; Xu, Min; Zhang, Quanan; Zhang, Xiaotong; Duan, Maoli] Xi An Jiao Tong Univ, Sch Med, Dept Otorhinolaryngol Head & Neck Surg, Affiliated Hosp 2, Xian 710004, Shaanxi Provinc, Peoples R China. [Zhang, Qing; Wei, Junrong; Xu, Min; Zhang, Quanan; Zhang, Xiaotong; Duan, Maoli] Xi An Jiao Tong Univ, Sch Med, Ear Inst, Affiliated Hosp 2, Xian 710004, Shaanxi Provinc, Peoples R China. [Dang, Shaonong] Xi An Jiao Tong Univ, Sch Med, Div Epidemiol & Biostat, Dept Publ Hlth, Xian 710004, Shaanxi Provinc, Peoples R China. [Zhang, Zhibao] Govt Xian, Educ Bur, Dept Eth Dev Hlth & Art, Xian, Peoples R China. [Huang, Xinsheng] Fudan Univ, Dept Otorhinolaryngol Head & Neck Surg, Zhongshan Hosp, Shanghai 200433, Peoples R China. [Huang, Xinsheng; Hellstrom, Sten; Duan, Maoli] Karolinska Univ Hosp, Dept Clin Sci Intervent & Technol, Stockholm, Sweden. [Hellstrom, Sten; Duan, Maoli] Karolinska Univ Hosp, Dept Neurotol & Audiol, Stockholm, Sweden. [Duan, Maoli] Karolinska Univ Hosp, Dept Otorhinolaryngol Head & Neck Surg, Stockholm, Sweden. [Anniko, Matti] Univ Uppsala Hosp, Dept Otorhinolaryngol Head & Neck Surg, Uppsala, Anniko, Sweden. RP Wei, JR (reprint author), Xi An Jiao Tong Univ, Sch Med, Dept Otorhinolaryngol Head & Neck Surg, Affiliated Hosp 2, Xian 710004, Shaanxi Provinc, Peoples R China. FU Bureau of the Science and Technology of Shaanxi Province [2004K16-G5(1)]; Second Hospital of Xi'an Jiaotong University [2003 YL-23]; Stiftelsen Tysta Skolan; Karolinska Institute FX From the Department of Otorhinolaryngology-Head and Neck Surgery and Ear Institute, The Second Affiliated Hospital (Qing Zhang, Wei, Xu, Quanan Zhang, Xiaotong Zhang, Duan), and the Division of Epidemiology and Biostatistics, Department of Public Health (Dang), Xi'an Jiaotong University School of Medicine, and the Department of Ethics, Development, Health and Art, Education Bureau, Government of Xi'an (Zhibao Zhang), Xi'an, and the Department of Otorhinolaryngology-Head and Neck Surgery, Zhongshan Hospital, Fudan University, Shanghai (Huang), People's Republic of China, and the Departments of Clinical Science Intervention and Technology (Huang, Hellstrom, Duan), Neurotology and Audiology (Hellstrom, Duan), and Otorhinolaryngology-Head and Neck Surgery (Duan), Karolinska University Hospital, Stockholm, and the Department of Otorhinolaryngology-Head and Neck Surgery, Uppsala University Hospital, Uppsala (Anniko), Sweden. This work was sponsored by a grant from the Bureau of the Science and Technology of Shaanxi Province (2004K16-G5(1)), a grant from the Second Hospital of Xi'an Jiaotong University (2003 YL-23), and Stiftelsen Tysta Skolan and Karolinska Institute. CR Auinger P, 2003, PEDIATRICS, V112, P514, DOI 10.1542/peds.112.3.514 Bronzetti G, 2004, PEDIATRICS, V113, P412, DOI 10.1542/peds.113.2.412 Casselbrant M, 2003, EVIDENCE BASED OTITI, P147 Caylan R, 2006, EUR ARCH OTO-RHINO-L, V263, P404, DOI 10.1007/s00405-005-1023-1 Chadha SK, 2006, J LARYNGOL OTOL, V120, P16, DOI 10.1017/S0022215105001520 Dang H S, 1998, Ann Otol Rhinol Laryngol, V107, P406 HOLMQUIST J, 1987, J LARYNGOL OTOL, V101, P116, DOI 10.1017/S0022215100101367 JERGER J, 1970, ARCHIV OTOLARYNGOL, V92, P311 Martines F, 2010, EUR ARCH OTO-RHINO-L, V267, P709, DOI 10.1007/s00405-009-1131-4 Olusesi AD, 2008, INT J PEDIATR OTORHI, V72, P787, DOI [10.1016/j.ijporl.2008.02.008, 10.1016/j.ijport.2008.02.008] Rushton HC, 1997, J LARYNGOL OTOL, V111, P804 Saim A, 1997, INT J PEDIATR OTORHI, V41, P21, DOI 10.1016/S0165-5876(97)00049-9 Takasaka T., 1990, ANN OTO RHINOL LARYN, V99, P13 Taylor Penelope S, 2009, Expert Rev Pharmacoecon Outcomes Res, V9, P133, DOI 10.1586/erp.09.6 Tong M C, 2000, Ear Nose Throat J, V79, P626 Tong MCF, 2006, INT J PEDIATR OTORHI, V70, P213, DOI 10.1016/j.ijpori.2005.06.004 TOS M, 1984, AM J OTOL, V5, P459 Yue V, 1997, Rev Laryngol Otol Rhinol (Bord), V118, P151 Zakzouk SM, 2002, SAUDI MED J, V23, P708 NR 19 TC 1 Z9 1 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD SEP PY 2011 VL 120 IS 9 BP 617 EP 621 PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA 824KB UT WOS:000295199700011 PM 22032077 ER PT J AU Khaja, SF Fletcher, AM Hoffman, HT AF Khaja, Sobia F. Fletcher, Aaron M. Hoffman, Henry T. TI Local Repair of Persistent Tracheocutaneous Fistulas SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE fistula; tracheocutaneous fistula; tracheostomy ID CLOSURE; CHILDREN; MANAGEMENT AB Tracheocutaneous fistulas may persist after tracheostomy. Suture closure of the fistula may result in complications, including infection, wound dehiscence, and pneumomediastinum. We present a simplified and relatively safe technique to close persistent fistulas that may be performed under local anesthesia. A retrospective chart review was performed on 13 patients who were successfully treated, including 1 with incomplete closure that was successfully addressed by additional procedures. Our review included analysis of reported risk factors for persistence of tracheocutaneous fistulas: previous irradiation of the neck, an extended duration of cannulation, previous tracheostomies, obesity, and use of a Bjork flap or 4-flap epithelial-lined tracheostomy. All 13 patients in the study were found to have at least 1 of these risk factors. C1 [Khaja, Sobia F.; Fletcher, Aaron M.; Hoffman, Henry T.] Univ Iowa Hosp & Clin, Dept Otolaryngol Head & Neck Surg, Iowa City, IA 52242 USA. RP Khaja, SF (reprint author), Univ Iowa Hosp & Clin, Dept Otolaryngol Head & Neck Surg, 200 Hawkins Dr,21253 PFP, Iowa City, IA 52242 USA. CR BERENHOLZ LP, 1992, ARCH OTOLARYNGOL, V118, P869 Drezner D A, 1998, Ear Nose Throat J, V77, P534 Eaton DA, 2003, ANN OTO RHINOL LARYN, V112, P17 Geyer M, 2008, CLIN OTOLARYNGOL, V33, P367, DOI 10.1111/j.1749-4486.2008.01729.x JACOBS JR, 1995, J SURG ONCOL, V59, P196, DOI 10.1002/jso.2930590312 KEENAN JP, 1978, ARCH OTOLARYNGOL, V104, P530 KULBER H, 1972, ARCHIV OTOLARYNGOL, V96, P22 Priestley JD, 2006, INT J PEDIATR OTORHI, V70, P1357, DOI 10.1016/j.ijporl.2006.01.014 WHITE AK, 1989, J OTOLARYNGOL, V18, P49 NR 9 TC 2 Z9 2 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD SEP PY 2011 VL 120 IS 9 BP 622 EP 626 PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA 824KB UT WOS:000295199700012 PM 22032078 ER PT J AU Beyea, JA Rotenberg, BW AF Beyea, Jason A. Rotenberg, Brian W. TI Comparison of Purified Plant Polysaccharide (HemoStase) Versus Gelatin-Thrombin Matrix (FloSeal) in Controlling Bleeding During Sinus Surgery: A Randomized Controlled Trial SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE bleeding; FESS; FloSeal Matrix; functional endoscopic sinus surgery; HemoStase ID RHINOSINUSITIS; AGENT AB Objectives: Purified plant polysaccharide (HemoStase) is a plant-derived hemostatic agent that has not previously been used in sinus surgery. This study was conducted to evaluate the effectiveness of this novel agent in the control of nasal bleeding during endoscopic sinus surgery. The volume of bleeding during endoscopic sinus surgery was hypothesized to not be statistically significantly different between a control group (gelatin-thrombin matrix; FloSeal) and an experimental group (purified plant polysaccharide; HemoStase). Methods: Eighteen patients with a history of chronic rhinosinusitis in whom maximal medical therapy failed who underwent endoscopic sinus surgery were randomized into one of two groups (control FloSeal group or experimental HemoStase group). In the control group, sites in the nose that were actively bleeding during the operation were controlled with FloSeal. In the experimental group, sites in the nose that were actively bleeding during the operation were controlled with HemoStase. The main outcome measure was total operative blood loss. Blood loss was the sum of blood removed by suction during the surgery (recorded in milliliters) and blood on surgical sponges (weighed and converted to milliliters). Statistical analysis was performed with the t-test and the Mann-Whitney U test. Results: The amounts of blood loss (mean +/- SEM) were not significantly different between the FloSeal (262 +/- 15 mL) and HemoStase (265 +/- 33 mL) groups (p = 0.93). Conclusions: The results of this study demonstrate the use of a novel product for the control of intraoperative bleeding during endoscopic sinus surgery. C1 [Rotenberg, Brian W.] Univ Western Ontario, Dept Otolaryngol Head & Neck Surg, Schulich Sch Med & Dent, St Josephs Hlth Care London, London, ON N6A 4V2, Canada. RP Rotenberg, BW (reprint author), Univ Western Ontario, Dept Otolaryngol Head & Neck Surg, Schulich Sch Med & Dent, St Josephs Hlth Care London, 268 Grosvenor St, London, ON N6A 4V2, Canada. CR Baumann A, 2003, RHINOLOGY, V41, P244 Bhattacharyya N, 2004, ARCH OTOLARYNGOL, V130, P329, DOI 10.1001/archotol.130.3.329 BOEZAART AP, 1995, CAN J ANAESTH, V42, P373 Chandra RK, 2005, AM J RHINOL, V19, P240 Chu Sau-Tung, 2006, J Chin Med Assoc, V69, P529 Gall RM, 2002, J OTOLARYNGOL, V31, P271, DOI 10.2310/7070.2002.29810 KENNER T, 1989, BASIC RES CARDIOL, V84, P111, DOI 10.1007/BF01907921 Meltzer Eli O, 2004, J Allergy Clin Immunol, V114, P155, DOI 10.1016/j.jaci.2004.09.029 *OP EP, OP EP SAMPL SIZ CALC Ragab SM, 2004, LARYNGOSCOPE, V114, P923, DOI 10.1097/00005537-200405000-00027 *RAND, RAND NUMB GEN Senior BA, 1998, LARYNGOSCOPE, V108, P151, DOI 10.1097/00005537-199802000-00001 Shrime MG, 2007, AM J RHINOL, V21, P174, DOI 10.2500/ajr.2007.21.2986 HEMOSTATE CLIN TRIAL NR 14 TC 4 Z9 4 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD AUG PY 2011 VL 120 IS 8 BP 495 EP 498 PG 4 WC Otorhinolaryngology SC Otorhinolaryngology GA 812EG UT WOS:000294273300001 PM 21922971 ER PT J AU Yoshida, H Kanda, Y Takahashi, H Miyamoto, I Chiba, K AF Yoshida, Haruo Kanda, Yukihiko Takahashi, Haruo Miyamoto, Izumi Chiba, Kenya TI Observation of Cortical Activity During Speech Stimulation in Prelingually Deafened Adults With Cochlear Implantation by Positron Emission Tomography-Computed Tomography SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE auditory cortex; auditory-verbal/oral education; positron emission tomography; regional cerebral blood flow ID CROSS-MODAL PLASTICITY; ALZHEIMERS-DISEASE; FDG PET; CHILDREN; DEAFNESS; BRAIN; ACTIVATION; SYSTEM AB Objectives: We evaluated the cortical activity of 2 successful prelingually deafened adult cochlear implant (Cl) users who have been trained by auditory-verbal/oral communication since childhood. Methods: Changes in regional cerebral blood flow were measured by positron emission tomography using (18)F-fluorodeoxyglucose while the subjects were receiving auditory language stimuli by listening to a story. Ten normal-hearing volunteers were observed as age-matched control subjects. Results: In both cases, the auditory-related regions, when compared to same regions in the control subjects, showed hypermetabolism in the left dorsolateral prefrontal cortex and the left precentral gyms similar to that in successful Cl users who are prelingually deafened children or postlingually deafened adults. Both subjects had the ability to activate these areas, and this ability might be one of the reasons that accounts for such exceptionally good performance in older prelingually deaf Cl users. As for the visual-related regions, hypometabolism was observed in Brodmann areas 18 and 19, and this finding might be related to the intensive auditory-verbal/oral education that the subjects had received since childhood. Conclusions: Despite the limits imposed by the small sample size and the spatial resolution of positron emission tomography, this study yielded insights into the nature of the brain plasticity in prelingually deafened adults who are successful CI users. C1 [Yoshida, Haruo; Kanda, Yukihiko; Takahashi, Haruo] Nagasaki Univ, Grad Sch Biomed Sci, Dept Otolaryngol Head & Neck Surg, Nagasaki 8528501, Japan. [Kanda, Yukihiko] Nagasaki Bell Hearing Ctr, Nagasaki, Japan. [Miyamoto, Izumi] Nishiisahaya Hosp, Dept Radiol, Nagasaki, Japan. [Chiba, Kenya] Nishiisahaya Hosp, Dept Orthoped Surg, Nagasaki, Japan. [Yoshida, Haruo] Ureshino Med Ctr, Dept Otolaryngol Head & Neck Surg, Saga, Japan. RP Yoshida, H (reprint author), Nagasaki Univ, Grad Sch Biomed Sci, Dept Otolaryngol Head & Neck Surg, 1-7-1 Sakamoto, Nagasaki 8528501, Japan. CR Arnoldner C, 2005, ACTA OTO-LARYNGOL, V125, P228, DOI 10.1080/00016480410022895 Badre D, 2004, NEURON, V41, P473, DOI 10.1016/S0896-6273(03)00851-1 Balkany TJ, 2002, ACTA OTO-LARYNGOL, V122, P356, DOI 10.1080/00016480260000012 BUSBY P A, 1991, British Journal of Audiology, V25, P291, DOI 10.3109/03005369109076601 Chee GH, 2004, J OTOLARYNGOL, V33, P26, DOI 10.2310/7070.2004.01074 Clopton Ben M, 2003, Ann Otol Rhinol Laryngol Suppl, V191, P26 Fujiki N, 2000, ANN OTO RHINOL LARYN, V109, P12 Fujiwara K, 2008, ACTA OTO-LARYNGOL, V128, P393, DOI 10.1080/00016480701714335 Giraud AL, 2001, NEURON, V30, P657, DOI 10.1016/S0896-6273(01)00318-X Giraud AL, 2000, BRAIN, V123, P1391, DOI 10.1093/brain/123.7.1391 Hirano S, 2000, Auris Nasus Larynx, V27, P303, DOI 10.1016/S0385-8146(00)00072-9 Ishii K, 2001, J NUCL MED, V42, P548 Ishii K, 2006, EUR J NUCL MED MOL I, V33, P575, DOI 10.1007/s00259-005-0015-0 Kang E, 2004, NEUROIMAGE, V22, P1173, DOI 10.1016/j.neuroimage.2004.02.036 Lee DS, 2001, NATURE, V409, P149, DOI 10.1038/35051653 Lee HJ, 2007, CEREB CORTEX, V17, P909, DOI 10.1093/cercor/bhl001 Lee JS, 2003, J NUCL MED, V44, P1435 MINOSHIMA S, 1995, J NUCL MED, V36, P1238 Naito Y, 2000, HEARING RES, V143, P139, DOI 10.1016/S0378-5955(00)00035-6 Oh SH, 2003, ACTA OTO-LARYNGOL, V123, P148, DOI 10.1080/0036554021000028111 POSNER MI, 1988, SCIENCE, V240, P1627, DOI 10.1126/science.3289116 QUARANTA N, 2004, ACTA OTO-LARYNGOL, V552, P68 SKINNER MW, 1992, LARYNGOSCOPE, V102, P797, DOI 10.1288/00005537-199207000-00009 Spelman FA, 2006, AUDIOL NEURO-OTOL, V11, P77, DOI 10.1159/000090680 Teoh SW, 2004, LARYNGOSCOPE, V114, P1536 Teoh SW, 2004, LARYNGOSCOPE, V114, P1714, DOI 10.1097/00005537-200410000-00007 Toner J, 2004, EAR HEARING, V25, P336, DOI 10.1097/01.AUD.0000134550.80305.04 Volle E, 2005, CEREB CORTEX, V15, P1064, DOI 10.1093/cercor/bhh207 Waltzmann SB, 2002, OTOL NEUROTOL, V23, P333, DOI 10.1097/00129492-200205000-00018 WALTZMAN SB, 1992, LARYNGOSCOPE, V102, P395, DOI 10.1288/00005537-199204000-00005 Waltzman SB, 1999, ANN OTO RHINOL LARYN, V108, P84 Wilson BS, 2005, EAR HEARING, V26, p73S, DOI 10.1097/00003446-200508001-00009 Yoshida H, 2008, AURIS NASUS LARYNX, V35, P349, DOI 10.1016/j.anl.2007.10.003 NR 33 TC 0 Z9 1 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD AUG PY 2011 VL 120 IS 8 BP 499 EP 504 PG 6 WC Otorhinolaryngology SC Otorhinolaryngology GA 812EG UT WOS:000294273300002 PM 21922972 ER PT J AU Turley, R Cohen, SM Becker, A Ebert, CS AF Turley, Richard Cohen, Seth M. Becker, Adam Ebert, Charles S., Jr. TI Role of Rhinitis in Laryngitis: Another Dimension of the Unified Airway SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article; Proceedings Paper CT Meeting of the American-Broncho-Esophagological-Association CY APR 27-28, 2011 CL Chicago, IL SP Amer Broncho Esophagol Assoc DE laryngitis; rhinitis; unified airway ID VOICE DISORDERS; ALLERGIC RHINITIS; GENERAL-POPULATION; DYSPHONIA; QUALITY; PREVALENCE; LARYNGEAL; REFLUX; IMPACT; QUESTIONNAIRE AB Objectives: We evaluated the prevalence of dysphonia and secondary laryngeal symptoms among patients with allergic rhinitis (AR), nonallergic rhinitis (NAR), and no rhinitis symptoms (controls). Methods: Patients with rhinitis symptoms with positive and negative allergy tests were recruited from allergy clinics, and patients without rhinitis symptoms were recruited from an orthopedic clinic. All groups completed the Voice-Related Quality of Life survey (VRQOL), the mini-Rhinoconjunctivitis Quality of Life Questionnaire (mini-RQLQ), and the Reflux Symptom Index (RSI). Results: Completing the study were 134 patients with AR, 54 patients with NAR, and 62 controls. Both AR and NAR patients had an increased prevalence of dysphonia compared to controls (32.8% and 26.9% versus 8.1%, respectively; p = 0.001). When we controlled for confounding variables such as asthma, inhaled steroid use, and gastroesophageal reflux, patients with either AR or NAR had higher odds of dysphonia (odds ratio, 4.22; 95% confidence interval, 1.03 to 17.32). Patients with worse mini-RQLQ scores had lower VRQOL scores and higher RSI scores (Spearman correlation of -0.47 and p < 0.001 and Spearman correlation of 0.6 and p < 0.001. respectively). Conclusions: Patients with rhinitis (AR or NAR) had a higher prevalence of dysphonia than did controls. Patients with worse rhinitis symptoms had worse voice-related quality of life and more severe chronic laryngeal symptoms. C1 [Turley, Richard; Cohen, Seth M.; Becker, Adam] Duke Univ, Med Ctr, Div Otolaryngol Head & Neck Surg, Durham, NC USA. [Cohen, Seth M.] Duke Univ, Med Ctr, Duke Voice Care Ctr, Durham, NC USA. [Ebert, Charles S., Jr.] Univ N Carolina Chapel Hill, Sch Med, Div Rhinol Allergy & Sinus Surg, Dept Otolaryngol Head & Neck Surg, Chapel Hill, NC USA. RP Cohen, SM (reprint author), DUMC Box 3805, Durham, NC 27710 USA. CR Abaza MM, 2007, OTOLARYNG CLIN N AM, V40, P1081, DOI 10.1016/j.otc.2007.05.010 Ahmed TF, 2006, AM J GASTROENTEROL, V101, P470, DOI 10.1111/j.1572.0241.2006.00502.x Belafsky PC, 2002, J VOICE, V16, P274, DOI 10.1016/S0892-1997(02)00097-8 Cecil M, 2001, J VOICE, V15, P270, DOI 10.1016/S0892-1997(01)00027-3 Cohen SM, 2010, LARYNGOSCOPE, V120, P2022, DOI 10.1002/lary.21058 Cohen SM, 2006, ANN OTO RHINOL LARYN, V115, P128 Dogan M, 2007, J VOICE, V21, P224, DOI 10.1016/j.jvoice.2005.11.003 Franic DM, 2005, J VOICE, V19, P300, DOI 10.1016/j.jvoice.2004.03.003 Hamdan AL, 2006, ARCH OTOLARYNGOL, V132, P547, DOI 10.1001/archotol.132.5.547 Hogikyan ND, 1999, J VOICE, V13, P557, DOI 10.1016/S0892-1997(99)80010-1 Jackson-Menaldi CA, 1999, J VOICE, V13, P113, DOI 10.1016/S0892-1997(99)80065-4 Juniper EF, 2000, CLIN EXP ALLERGY, V30, P132 Koufman JA, 2000, OTOLARYNG HEAD NECK, V123, P385, DOI 10.1067/mhn.2000.109935 Krouse JH, 2010, OTOLARYNG CLIN N AM, V43, P111, DOI 10.1016/j.otc.2009.11.005 Krouse JH, 2008, OTOLARYNG HEAD NECK, V139, P149, DOI 10.1016/j.otohns.2008.04.001 Krouse JH, 2008, OTOLARYNG CLIN N AM, V41, P257, DOI 10.1016/j.otc.2007.11.002 Meggs WJ, 1996, ARCH ENVIRON HEALTH, V51, P275 Millqvist E, 2008, J VOICE, V22, P512, DOI 10.1016/j.jvoice.2006.12.003 Mirza N, 2004, LARYNGOSCOPE, V114, P1566, DOI 10.1097/00005537-200409000-00012 Nathan RA, 1997, J ALLERGY CLIN IMMUN, V99, pS808, DOI 10.1016/S0091-6749(97)80040-1 Randhawa PS, 2010, LOGOP PHONIATR VOCO, V35, P169, DOI 10.3109/14015431003599012 Randhawa PS, 2010, LOGOP PHONIATR VOCO, V35, P1, DOI 10.1080/14015430903002262 Reidy PM, 2003, OTOLARYNG HEAD NECK, V128, P455, DOI 10.1016/mhn.2003.108 Roth D, 2010, CURR OPIN OTOLARYNGO, V18, P176, DOI 10.1097/MOO.0b013e32833952af Roy N, 2005, LARYNGOSCOPE, V115, P1988, DOI 10.1097/01.mlg.0000179174.32345.41 Simberg S, 2009, J VOICE, V23, P136, DOI 10.1016/j.jvoice.2007.03.010 Turley R, 2010, OTOLARYNG HEAD NECK, V142, P310, DOI 10.1016/j.otohns.2009.12.022 van Oene CM, 2007, ALLERGY, V62, P1359, DOI 10.1111/j.1398-9995.2007.01482.x NR 28 TC 4 Z9 5 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD AUG PY 2011 VL 120 IS 8 BP 505 EP 510 PG 6 WC Otorhinolaryngology SC Otorhinolaryngology GA 812EG UT WOS:000294273300003 PM 21922973 ER PT J AU Plaza, G Eisenberg, G Montojo, J Onrubia, T Urbasos, M O'Connor, C AF Plaza, Guillermo Eisenberg, Gustavo Montojo, Jose Onrubia, Tomas Urbasos, Maria O'Connor, Carlos TI Balloon Dilation of the Frontal Recess: A Randomized Clinical Trial SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE balloon; dilation; frontal sinus; randomized clinical trial; sinuplasty; sinusitis ID ENDOSCOPIC SINUS SURGERY; CATHETER SINUSOTOMY; CHRONIC RHINOSINUSITIS; FOLLOW-UP; SINUPLASTY; SAFETY; DILATATION; OUTCOMES; FEASIBILITY; OSTIA AB Objectives: We sought to evaluate the effectiveness and safety of balloon dilation of the frontal recess in the management of chronic rhinosinusitis of the frontal sinus. Methods: We designed a double-blind randomized clinical trial of functional endoscopic sinus surgery assisted by balloon dilation versus conventional functional endoscopic sinus surgery in the treatment of chronic rhinosinusitis of the frontal sinus. We enrolled a total of 40 patients in whom medical therapy had failed. The patients were randomly allocated to balloon dilation or to conventional frontal sinus drainage with a Draf I procedure. The main outcome measures were resolution of frontal sinus disease confirmed by computed tomographic scan, and permeability of the frontal recess seen on endoscopy, both at 12 months. Results: Of the 40 patients enrolled, 32 concluded the trial. In both groups, we obtained a statistically significant reduction in the Lund-Mackay stage. Resolution of frontal sinus disease confirmed by computed tomographic scan seemed to be more common after balloon dilation, although this finding was not statistically significant. Permeability of the frontal recess was seen on endoscopy statistically more frequently after balloon treatment (73% versus 62.5%). Only 4 patients needed revision surgery. No major complications were observed. Conclusions: Balloon dilation of the frontal recess is a relatively safe and effective tool in the management of chronic frontal rhinosinusitis after intensive medical treatment has failed. C1 [Plaza, Guillermo; Eisenberg, Gustavo; Montojo, Jose; Onrubia, Tomas] Univ Rey Juan Carlos, Dept Otolaryngol, Hosp Univ Fuenlabrada, Madrid 28942, Spain. [Urbasos, Maria] Univ Rey Juan Carlos, Dept Neuroradiol, Hosp Univ Fuenlabrada, Madrid 28942, Spain. [O'Connor, Carlos] Univ Seville, Dept Otolaryngol, Hosp USP Marbella, Seville, Spain. RP Plaza, G (reprint author), Univ Rey Juan Carlos, Dept Otolaryngol, Hosp Univ Fuenlabrada, Co Molino 2, Madrid 28942, Spain. FU Spanish Ministry of Health [P107/90640] FX This study was supported by grant FIS (Fondo de Investigaciones Sanitarias) P107/90640 from the Spanish Ministry of Health. CR Albritton FD, 2009, OTOLARYNG HEAD NECK, V140, P834, DOI 10.1016/j.otohns.2009.01.013 Anand VK, 2004, ANN OTO RHINOL LARYN, V113, P3 Anderson P, 2009, LARYNGOSCOPE, V119, P1828, DOI 10.1002/lary.20565 Andrews JN, 2010, AVIAT SPACE ENVIR MD, V81, P514, DOI 10.3357/ASEM.2716.2010 Batra PS, 2011, LARYNGOSCOPE, V121, P226, DOI 10.1002/lary.21114 Bhandarkar ND, 2010, LARYNGOSCOPE, V120, P2015, DOI 10.1002/lary.21110 Bolger WE, 2006, AM J RHINOL, V20, P290, DOI 10.2500/ajr.2006.20.2868 Bolger WE, 2007, OTOLARYNG HEAD NECK, V137, P10, DOI 10.1016/j.otohns.2007.02.006 Brown CL, 2006, ANN OTO RHINOL LARYN, V115, P293 Catalano PJ, 2009, ANN OTO RHINOL LARYN, V118, P107 Chan Y, 2009, LARYNGOSCOPE, V119, P1229, DOI 10.1002/lary.20168 Fokkens W, 2007, RHINOL S, V20, P1 Friedman M, 2006, OP TECH OTOLARYNGOL, V17, P126, DOI 10.1016/j.otot.2006.03.005 Friedman M, 2008, AM J RHINOL, V22, P204, DOI 10.2500/ajr.2008.22.3155 Friedman M, 2009, LARYNGOSCOPE, V119, P1399, DOI 10.1002/lary.20479 Garvey Christopher M, 2009, Ear Nose Throat J, V88, pE12 Govindaraj S, 2010, J LARYNGOL OTOL, V124, P242, DOI 10.1017/S0022215109991368 Hopkins C, 2007, OTOLARYNG HEAD NECK, V137, P555, DOI 10.1016/j.otohns.2007.02.004 Hopkins C, 2011, J LARYNGOL OTOL, V125, P43, DOI 10.1017/S0022215110001520 Hopkins C, 2009, RHINOLOGY, V47, P375, DOI 10.4193/Rhin08.057 Khalid AN, 2010, AMJ RHINOL ALLERGY, V24, P55, DOI 10.2500/ajra.2010.24.3419 Kieff DA, 2009, LARYNGOSCOPE, V119, P2454, DOI 10.1002/lary.20640 Kim Esther, 2009, Otolaryngol Clin North Am, V42, P847, DOI 10.1016/j.otc.2009.07.006 Kim E, 2009, OTOLARYNGOL CLIN N A, V42, px Kountakis S, 2005, FRONTAL SINUS Kuhn FA, 2008, OTOLARYNG HEAD NECK, V139, pS27, DOI 10.1016/j.otohns.2008.05.010 Kutluhan A, 2009, ANN OTO RHINOL LARYN, V118, P881 Levine HL, 2008, ANN OTO RHINOL LARYN, V117, P263 Luong A, 2008, AM J RHINOL, V22, P621, DOI 10.2500/ajr.2008.22.3240 Schulz KF, 2010, ANN INTERN MED, V152, P726, DOI 10.7326/0003-4819-152-11-201006010-00232 Toledano A, 2006, Acta Otorrinolaringol Esp, V57, P401 Tomazic PV, 2010, RHINOLOGY, V48, P247, DOI 10.4193/Rhin09.129 Vaughan WC, 2008, CURR OPIN OTOLARYNGO, V16, P2, DOI 10.1097/MOO.0b013e3282f5e955 Weiss RL, 2008, OTOLARYNG HEAD NECK, V139, pS38, DOI 10.1016/j.otohns.2008.06.008 Welch KC, 2010, OTOLARYNG CLIN N AM, V43, P565, DOI 10.1016/j.otc.2010.02.021 Wittkopf ML, 2009, OTOLARYNG HEAD NECK, V140, P596, DOI 10.1016/j.otohns.2008.12.040 Wycherly BJ, 2010, ANN OTO RHINOL LARYN, V119, P468 NR 37 TC 20 Z9 20 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD AUG PY 2011 VL 120 IS 8 BP 511 EP 518 PG 8 WC Otorhinolaryngology SC Otorhinolaryngology GA 812EG UT WOS:000294273300004 PM 21922974 ER PT J AU Nakaya, M Onuki, Y Kida, W Watanabe, K Abe, K AF Nakaya, Muneo Onuki, Yuka Kida, Wataru Watanabe, Kenta Abe, Kazuya TI New Surgical Procedure for Laryngotracheal Separation Without a Cannula or Postoperative Treatment SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE intractable aspiration; laryngotracheal separation; tracheal closure AB Objectives: Laryngotracheal separation is a surgical procedure used in the treatment of intractable aspiration. As with total laryngectomy and laryngotracheal diversion, this procedure requires postoperative pressure above the suture location to prevent leakage at the anastomosis. To date, there have been no reports regarding laryngeal separation without postoperative treatment. The purpose of this study was to evaluate a new surgical procedure for laryngotracheal separation that is performed without a cannula and requires no postoperative treatment. Methods: We performed the new surgical procedure in 7 patients. The mucosa of the cricoid cartilage was sutured to achieve tracheal closure. The closure was covered with a musculocutaneous flap of strap muscle; gauze was then tied over the skin and a 2-0 nylon suture was used to pierce the posterior part of the cricoid cartilage. In addition, a permanent tracheostoma was constructed without a tracheal cannula. Results: No patients required a tracheal cannula or treatment after the operation. Additionally, aspiration pneumonia was prevented without complications in all patients. Conclusions: This new surgical procedure eliminates the need for a cannula and postoperative treatment. The effects of this method in terms of aspiration prevention are comparable to those of other surgical techniques. C1 [Nakaya, Muneo; Onuki, Yuka; Kida, Wataru; Watanabe, Kenta; Abe, Kazuya] Tokyo Metropolitan Tama Med Ctr, Dept Otolaryngol, Fuchu, Tokyo 1838524, Japan. RP Nakaya, M (reprint author), Tokyo Metropolitan Tama Med Ctr, Dept Otolaryngol, 2-8-29 Musashidai, Fuchu, Tokyo 1838524, Japan. CR Hazarika P, 2002, J LARYNGOL OTOL, V116, P562 Ninomiya H, 2008, LARYNGOSCOPE, V118, P958, DOI 10.1097/MLG.0b013e3181677095 Shima H, 2010, PEDIATR SURG INT, V26, P1041, DOI 10.1007/s00383-010-2649-7 Tatekawa Y, 2010, PEDIATR SURG INT, V26, P553, DOI 10.1007/s00383-010-2567-8 Watanabe K, 2011, AM J OTOLARYNG, V32, P156, DOI 10.1016/j.amjoto.2009.10.003 Yarington C T, 1976, Ann Otol Rhinol Laryngol, V85, P609 NR 6 TC 1 Z9 1 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD AUG PY 2011 VL 120 IS 8 BP 519 EP 522 PG 4 WC Otorhinolaryngology SC Otorhinolaryngology GA 812EG UT WOS:000294273300005 PM 21922975 ER PT J AU Kim, DK Park, SN Kim, HM Son, HR Kim, NG Park, KH Yeo, SW AF Kim, Dong-Kee Park, Shi-Nae Kim, Hyung Min Son, Hye Rim Kim, Nam-Gyun Park, Kyoung-Ho Yeo, Sang Won TI Prevalence and Significance of High-Frequency Hearing Loss in Subjectively Normal-Hearing Patients With Tinnitus SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE extended high-frequency audiometry; hearing loss; normal hearing; tinnitus ID SPONTANEOUS OTOACOUSTIC EMISSIONS; MECHANISMS; AUDIOGRAM; DIAGNOSIS; RESPONSES; LOUDNESS AB Objectives: We investigated the incidences of high-frequency hearing loss (HFHL; above 2 kHz) and extended high-frequency hearing loss (EHFHL; above 8 kHz) in patients with tinnitus and subjectively normal hearing, and evaluated their effects on the clinical and audiological features of the patients. Methods: The sample included 85 patients with sensorineural tinnitus who had normal hearing sensitivity in the frequencies from 250 Hz to 2 kHz, and who had undergone extended high-frequency audiometry between July 2009 and February 2010. We investigated the incidences of HFHL and EHFHL in these patients and analyzed the significance of the hearing losses. Results: The incidence of HFHL or EHFHL was 88%. The proportion of patients with EHFHL, among the patients who had normal hearing sensitivity up to 8 kHz, was about 74%. The patients with normal hearing sensitivity at all test frequencies were significantly younger, had larger otoacoustic emissions, and had tinnitus that was less loud as measured by tinnitus matching than did the subjects with HFHL and/or EHFHL. However, other comparisons of clinical factors in the three groups did not show any differences. Conclusions: Even if patients with tinnitus do not have any subjective hearing impairment, most of them have HFHL and/or EHFHL. The effects on the clinical features of the patients are still vague. C1 [Kim, Dong-Kee; Park, Shi-Nae; Kim, Hyung Min; Son, Hye Rim; Kim, Nam-Gyun; Park, Kyoung-Ho; Yeo, Sang Won] Catholic Univ Korea, Dept Otolaryngol Head & Neck Surg, Coll Med, Seoul 137701, South Korea. RP Park, SN (reprint author), Catholic Univ Korea, Dept Otolaryngol Head & Neck Surg, Seoul St Marys Hosp, Coll Med, 505 Banpo Dong, Seoul 137701, South Korea. CR BARNEA G, 1990, AUDIOLOGY, V29, P36 Ceranic BJ, 1998, AUDIOL NEURO-OTOL, V3, P332, DOI 10.1159/000013803 DAUMAN R, 1992, TINNITUS 91, P225 Granjeiro RC, 2008, OTOLARYNG HEAD NECK, V138, P502, DOI 10.1016/j.otohns.2007.11.012 Hiller W, 2007, AUDIOL NEURO-OTOL, V12, P391, DOI 10.1159/000106482 IKNER CL, 1990, EAR HEARING, V11, P16, DOI 10.1097/00003446-199002000-00005 JASTREBOFF PJ, 1990, NEUROSCI RES, V8, P221, DOI 10.1016/0168-0102(90)90031-9 Kehrle HM, 2008, ARCH OTOLARYNGOL, V134, P647, DOI 10.1001/archotol.134.6.647 Kim DK, 2011, J LARYNGOL OTOL, V125, P246, DOI 10.1017/S0022215110002380 Moller AR, 2007, PROG BRAIN RES, V166, P37, DOI 10.1016/S0079-6123(07)66003-8 Moore BCJ, 2000, BRIT J AUDIOL, V34, P205 Newman CW, 1996, ARCH OTOLARYNGOL, V122, P143 Noble W, 2007, INT J AUDIOL, V46, P569, DOI 10.1080/14992020701506296 Norena A, 2002, AUDIOL NEURO-OTOL, V7, P358, DOI 10.1159/000066156 NORTON SJ, 1990, EAR HEARING, V11, P159, DOI 10.1097/00003446-199004000-00011 Paglialonga A, 2010, AURIS NASUS LARYNX, V37, P291, DOI 10.1016/j.anl.2009.09.009 Pan T, 2009, INT J AUDIOL, V48, P277, DOI 10.1080/14992020802581974 PLINKERT PK, 1990, ACTA OTO-LARYNGOL, V110, P342, DOI 10.3109/00016489009107453 Preece JP, 2003, GERIATR AGING, V6, P22 Riga M, 2007, OTOL NEUROTOL, V28, P185, DOI 10.1097/MAO.0b013e31802e2a14 Shim HJ, 2009, CLIN EXP OTORHINOLAR, V2, P169, DOI 10.3342/ceo.2009.2.4.169 Shiomi Y, 1997, HEARING RES, V108, P83, DOI 10.1016/S0378-5955(97)00043-9 SHULMAN A, 1981, LARYNGOSCOPE, V91, P2025 Thabet EM, 2009, AURIS NASUS LARYNX, V36, P633, DOI 10.1016/j.anl.2009.01.002 TYLER RS, 1983, J SPEECH HEAR RES, V26, P59 Tyler RS, 2007, PROG BRAIN RES, V166, P499, DOI 10.1016/S0079-6123(07)66048-8 Tyler R S, 1982, Br J Audiol, V16, P193, DOI 10.3109/03005368209081498 Weisz N, 2006, HEARING RES, V222, P108, DOI 10.1016/j.heares.2006.09.003 NR 28 TC 11 Z9 11 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD AUG PY 2011 VL 120 IS 8 BP 523 EP 528 PG 6 WC Otorhinolaryngology SC Otorhinolaryngology GA 812EG UT WOS:000294273300006 PM 21922976 ER PT J AU Jia, H Venail, F Piron, JP Batrel, C Pelliccia, P Artieres, F Uziel, A Mondain, M AF Jia, Huan Venail, Frederic Piron, Jean-Pierre Batrel, Charlene Pelliccia, Pierfrancesco Artieres, Francoise Uziel, Alain Mondain, Michel TI Effect of Surgical Technique on Electrode Impedance After Cochlear Implantation SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE cochlear implant; fibrosis; impedance value; residual hearing; soft surgery ID CHRONIC ELECTRICAL-STIMULATION; RESIDUAL HEARING; AUDITORY-NERVE; INTRACOCHLEAR; PRESERVATION; FIBROSIS; BONE AB Objectives: We compare the evolution of electrode impedance values (IVs) following either conventional cochlear implantation or implantation by the soft surgery (SS) technique. Methods: We performed a retrospective chart review of 20 consecutive adult patients who underwent implantation with the Nucleus CA 24 device between 2004 and 2007. Five patients with preoperative residual hearing at the frequencies 256, 512, and 1,024 Hz underwent implantation by an SS cochlear implantation technique (SS group), and the 15 other patients underwent a conventional implantation technique (conventional cochleostomy [CC] group). The active electrodes were classified as distal (17 to 22), middle (10 to 16), or proximal (3 to 9) according to their position in relation to the tip of the electrode array. Their IVs were collected at I, 3, 12, 24, and 36 months after implantation. Changes in auditory thresholds at 3 and 24 months were reported for patients in the SS group. Results: The postoperative IVs of both the CC and SS groups decreased significantly between I and 3 Months after implantation (p < 0.05) and then remained stable. The IVs after 12 months were significantly lower (p < 0.05) in the SS group than in the CC group. Conclusions: Patients who underwent the SS technique displayed lower long-term electrode IVs than did their counterparts in the CC group. If electrode IVs are indeed an indirect representation of cochlear fibrosis, the use of the SS technique in lieu of the CC technique could reduce fibrotic development. C1 [Jia, Huan; Venail, Frederic; Piron, Jean-Pierre; Batrel, Charlene; Pelliccia, Pierfrancesco; Artieres, Francoise; Uziel, Alain; Mondain, Michel] Univ Hosp, Dept Ear Nose & Throat, Montpellier, France. [Jia, Huan; Venail, Frederic; Piron, Jean-Pierre; Batrel, Charlene; Pelliccia, Pierfrancesco; Artieres, Francoise; Uziel, Alain; Mondain, Michel] Univ Hosp, Cochlear Implant Ctr, Montpellier, France. [Jia, Huan; Venail, Frederic; Batrel, Charlene; Uziel, Alain; Mondain, Michel] Inst Neurosci Montpellier, INSERM, U1051, Montpellier, France. [Piron, Jean-Pierre; Artieres, Francoise] St Pierre Inst, Audiophonol Dept, Palavas Les Flots, France. [Jia, Huan] Shanghai Jiao Tong Univ, Dept Otolaryngol Head & Neck Surg, Xinhua Hosp, Sch Med, Shanghai 200030, Peoples R China. [Jia, Huan] Shanghai Jiao Tong Univ, Ear Inst, Xinhua Hosp, Sch Med, Shanghai 200030, Peoples R China. RP Mondain, M (reprint author), CHRU, ORL B, 80 Rue Augustin Fliche, F-34295 Montpellier 5, France. CR Abi-Hachem Ralph N, 2010, Recent Pat CNS Drug Discov, V5, P147 Busby PA, 2005, EAR HEARING, V26, P504, DOI 10.1097/01.aud.0000179693.32989.84 Choi CH, 2005, HEARING RES, V205, P193, DOI 10.1016/j.heares.2005.03.018 Clark G M, 1995, Ann Otol Rhinol Laryngol Suppl, V166, P40 Cohen NL, 1997, OTOLARYNG HEAD NECK, V117, P214, DOI 10.1016/S0194-5998(97)70176-1 Duan YY, 2004, BIOMATERIALS, V25, P3813, DOI 10.1016/j.biomaterials.2003.09.107 Eshraghi Adrien A, 2006, Curr Opin Otolaryngol Head Neck Surg, V14, P323, DOI 10.1097/01.moo.0000244189.74431.df Fayad JN, 2009, OTOLARYNG HEAD NECK, V141, P247, DOI 10.1016/j.otohns.2009.03.031 Garcia-Ibanez L, 2009, ACTA OTO-LARYNGOL, V129, P651, DOI 10.1080/00016480802369278 Henkin Y, 2003, INT J PEDIATR OTORHI, V67, P873, DOI 10.1016/S0165-5876(03)00131-9 Hughes ML, 2001, EAR HEARING, V22, P471, DOI 10.1097/00003446-200112000-00004 James C, 2005, ACTA OTO-LARYNGOL, V125, P481, DOI 10.1080/00016480510026197 Kawano A, 1998, ACTA OTO-LARYNGOL, V118, P313 Li PMMC, 2007, ANN OTO RHINOL LARYN, V116, P731 Paasche G, 2009, OTOL NEUROTOL, V30, P592, DOI 10.1097/MAO.0b013e3181ab8fba Swanson B, 1995, Ann Otol Rhinol Laryngol Suppl, V166, P141 Tykocinski M, 2001, HEARING RES, V159, P53, DOI 10.1016/S0378-5955(01)00320-3 Xu J, 1997, HEARING RES, V105, P1, DOI 10.1016/S0378-5955(96)00193-1 NR 18 TC 7 Z9 7 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD AUG PY 2011 VL 120 IS 8 BP 529 EP 534 PG 6 WC Otorhinolaryngology SC Otorhinolaryngology GA 812EG UT WOS:000294273300007 PM 21922977 ER PT J AU Yung, M Vivekanandan, S Smith, P AF Yung, Matthew Vivekanandan, Senthilnathan Smith, Philip TI Randomized Study Comparing Fascia and Cartilage Grafts in Myringoplasty SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE cartilage; fascia; random allocation; tympanoplasty ID TEMPORALIS FASCIA; TYMPANOPLASTY; CHILDREN AB Objectives: The study compares the medium-term outcomes of myringoplasty procedures using fascia and cartilage grafts. Methods: Patients with chronic otitis media with perforations larger than 50% of the size of the tympanic membrane were included in a randomized, controlled, prospective clinical trial. The perforations were repaired with either temporalis fascia (20 ears) or cartilage (18 ears) grafts selected randomly. A search of the literature was performed to look for other randomized studies comparing fascia and cartilage. Results: The graft take rates of fascia and cartilage grafts at 24 months were 84.2% and 80%, respectively. The postoperative air-bone gaps and hearing gains at 24 months were 16.97 dB and 13.63 dB, respectively, in the fascia group and 20.63 dB and 12.60 dB, respectively, in the cartilage group. There was no significant difference in the graft take rates or postoperative hearing between the two groups. The literature search identified one other randomized study comparing fascia and cartilage grafts in the repair of large perforations. The pooled data from the two studies did not show a difference in the graft take rates or hearing gains between cartilage and fascia. Conclusions: There was no statistical difference in the outcomes of fascia and cartilage grafts in the repair of large perforations. C1 [Yung, Matthew; Vivekanandan, Senthilnathan; Smith, Philip] Ipswich Hosp Natl Hlth Serv Trust, Dept Otolaryngol, Ipswich IP5 4PD, Suffolk, England. RP Yung, M (reprint author), Ipswich Hosp Natl Hlth Serv Trust, Dept Otolaryngol, Heath Rd, Ipswich IP5 4PD, Suffolk, England. CR [Anonymous], 1995, OTOLARYNGOL HEAD NEC, V113, P186 Cabra J, 2010, OTOL NEUROTOL, V31, P589, DOI 10.1097/MAO.0b013e3181dbb35e Couloigner V, 2005, OTOL NEUROTOL, V26, P247, DOI 10.1097/00129492-200503000-00020 Dornhoffer JL, 1997, LARYNGOSCOPE, V107, P1094, DOI 10.1097/00005537-199708000-00016 Gerber MJ, 2000, LARYNGOSCOPE, V110, P1994, DOI 10.1097/00005537-200012000-00002 Gierek Tatiana, 2004, Otolaryngol Pol, V58, P529 Kazikdas KC, 2007, EUR ARCH OTO-RHINO-L, V264, P985, DOI 10.1007/s00405-007-0291-3 Kotecha B, 1999, CLIN OTOLARYNGOL, V24, P126 Mauri M, 2001, LARYNGOSCOPE, V111, P1479, DOI 10.1097/00005537-200108000-00027 Ozbek C, 2008, OTOL NEUROTOL, V29, P679, DOI 10.1097/MAO.0b013e31817dad57 SCHUKNECHT HF, 1985, LARYNGOSCOPE, V95, P249 Solmaz Mehmet Ali, 2002, Kulak Burun Bogaz Ihtis Derg, V9, P271 Yetiser S, 2009, ANN OTO RHINOL LARYN, V118, P570 YUNG MW, 1995, CLIN OTOLARYNGOL, V20, P241, DOI 10.1111/j.1365-2273.1995.tb01858.x NR 14 TC 7 Z9 7 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD AUG PY 2011 VL 120 IS 8 BP 535 EP 541 PG 7 WC Otorhinolaryngology SC Otorhinolaryngology GA 812EG UT WOS:000294273300008 PM 21922978 ER PT J AU Cole, S Kearns, D Magit, A AF Cole, Stephanie Kearns, Donald Magit, Anthony TI Chronic Esophageal Foreign Bodies and Secondary Mediastinitis in Children SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE complication; esophageal foreign body; mediastinitis; treatment ID NONOPERATIVE MANAGEMENT; BODY AB Objectives: The purpose of this study was to review the clinical presentation, diagnosis, and management of chronic esophageal foreign bodies complicated by mediastinitis in children. Methods: A retrospective study of children with a chronic esophageal foreign body and secondary mediastinal complications diagnosed at Rady Children's Hospital in San Diego over a 12-month period is reported. Results: Three patients received a diagnosis of an esophageal foreign body, retained from 1 to 12 months, and mediastinitis. Each patient presented primarily with respiratory signs and had been treated previously for alternate diagnoses (ie, asthma, reflux, and upper respiratory tract infection) by emergency or pediatric providers. The diagnosis of a foreign body was made after a chest radiograph was examined. Operative airway evaluation confirmed tracheal narrowing in all patients, and a computed tomographic scan of the chest was performed after removal of the foreign body to confirm mediastinal involvement. After medical and/or surgical treatment, the patients were released from the hospital tolerating soft diets. There were no reports of long-term complications in our series of patients. Conclusions: It is critical to rule out esophageal and airway foreign bodies in pediatric patients with respiratory symptoms that do not respond to medical treatment. Timely recognition of an esophageal foreign body generally allows for removal with minimal morbidity, whereas the incidence of serious complications increases significantly when the diagnosis is delayed. Our series provides support for conservative management of mediastinal complications after removal of chronically retained esophageal foreign bodies in children. C1 [Cole, Stephanie] USN, San Diego Med Ctr, Dept Otolaryngol, San Diego, CA USA. [Kearns, Donald; Magit, Anthony] Rady Childrens Hosp, Dept Otolaryngol, San Diego, CA USA. RP Cole, S (reprint author), 100 Brewster Blvd, Camp Lejeune, NC 28547 USA. CR CAMERON JL, 1979, ANN THORAC SURG, V27, P404 Lemberg PS, 1996, ANN OTO RHINOL LARYN, V105, P267 Friedman EM, 2000, OTOLARYNG CLIN N AM, V33, P179, DOI 10.1016/S0030-6665(05)70214-0 Gilchrist BF, 1997, J PEDIATR SURG, V32, P1429, DOI 10.1016/S0022-3468(97)90554-6 HAWKINS DB, 1990, ANN OTO RHINOL LARYN, V99, P935 HEAD JR, 1938, AM J SURG, V42, P266, DOI 10.1016/S0002-9610(38)91175-4 Kerschner JE, 2001, INT J PEDIATR OTORHI, V59, P89, DOI 10.1016/S0165-5876(01)00454-2 LABUDA CS, 2005, CONT DIAGN RADIOL, V28, P1 Louie JP, 2005, PEDIATR EMERG CARE, V21, P582, DOI 10.1097/01.pec.0000177196.83655.91 MICHEL L, 1981, ANN SURG, V194, P57, DOI 10.1097/00000658-198107000-00010 Miller RS, 2004, INT J PEDIATR OTORHI, V68, P265, DOI 10.1016/j.ijporl.2003.09.021 Mohiuddin S, 2004, SOUTH MED J, V97, P93, DOI 10.1097/01.SMJ.0000091033.99691.0D Reilly J, 1997, LARYNGOSCOPE, V107, P17, DOI 10.1097/00005537-199701000-00006 Singh B, 1997, ANN OTO RHINOL LARYN, V106, P301 Stuth EAE, 2001, ANESTHESIOLOGY, V95, P1025, DOI 10.1097/00000542-200110000-00036 NR 15 TC 1 Z9 1 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD AUG PY 2011 VL 120 IS 8 BP 542 EP 545 PG 4 WC Otorhinolaryngology SC Otorhinolaryngology GA 812EG UT WOS:000294273300009 PM 21922979 ER PT J AU Rutt, AL Poulik, J Siddiqui, AH Konski, A Kalaf, M Madgy, DN Wang, ZHJ AF Rutt, Amy L. Poulik, Janet Siddiqui, Abdul Hafeez Konski, Andre Kalaf, Majid Madgy, David N. Wang, Zhihong J. TI NUT Midline Carcinoma Mimicking Tonsillitis in an Eight-Year-Old Girl SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE FDG-PET; NUT midline carcinoma; tonsillitis ID CHILDREN; ENLARGEMENT; FUSION; NECK; HEAD AB We review a unique case of NUT midline carcinoma that presented in a young girl with an initial diagnosis of tonsillar abscess. We stress the importance of assaying poorly differentiated carcinomas in young patients for the t(15;19) translocation. Our patient presented with tonsillar enlargement and cervical lymphadenopathy mimicking acute tonsillitis. The clinical suspicion for malignancy arose after an aspirate from the tonsil did not yield any pus, and biopsy of a cervical lymph node demonstrated undifferentiated carcinoma. Further analysis by fluorescence in situ hybridization was positive for rearrangements in both BRD4 and NUT genes consistent with NUT carcinoma. In addition, fluorodeoxyglucose positron emission tomography (FDG-PET) revealed a very high standard uptake value in both the primary tumor and metastatic foci, suggesting that FDG-PET could be a useful tool in the staging and follow-up of NUT midline carcinoma. C1 [Siddiqui, Abdul Hafeez; Wang, Zhihong J.] Childrens Hosp Michigan, Div Pediat Hematol Oncol, Detroit, MI 48201 USA. [Rutt, Amy L.; Madgy, David N.] Childrens Hosp Michigan, Dept Otolaryngol, Detroit, MI 48201 USA. [Poulik, Janet] Childrens Hosp Michigan, Dept Pathol, Detroit, MI 48201 USA. [Kalaf, Majid] Childrens Hosp Michigan, PET Ctr, Detroit, MI 48201 USA. [Konski, Andre] Wayne State Univ, Dept Radiat Oncol, Karmanos Canc Inst, Detroit, MI 48202 USA. RP Wang, ZHJ (reprint author), Childrens Hosp Michigan, Div Hematol Oncol, 3901 Beaubien, Detroit, MI 48201 USA. CR Berkowitz RG, 1999, ANN OTO RHINOL LARYN, V108, P876 CUNNINGHAM MJ, 1987, INT J PEDIATR OTORHI, V13, P279, DOI 10.1016/0165-5876(87)90109-1 Deantonio L, 2008, RADIAT ONCOL, V3, DOI 10.1186/1748-717X-3-29 French CA, 2008, ONCOGENE, V27, P2237, DOI 10.1038/sj.onc.1210852 French CA, 2003, CANCER RES, V63, P304 French CA, 2010, J CLIN PATHOL, V63, P492, DOI 10.1136/jcp.2007.052902 French CA, 2004, J CLIN ONCOL, V22, P4135, DOI 10.1200/JCO.2004.02.107 Haack H, 2009, AM J SURG PATHOL, V33, P984, DOI 10.1097/PAS.0b013e318198d666 Harley EH, 2002, ARCH OTOLARYNGOL, V128, P767 KUBONISHI I, 1991, CANCER RES, V51, P3327 LEE ACW, 1993, CANCER, V72, P2273, DOI 10.1002/1097-0142(19931001)72:7<2273::AID-CNCR2820720735>3.0.CO;2-U Leung Alexander K C, 2004, J Pediatr Health Care, V18, P3, DOI 10.1016/j.pedhc.2003.08.008 Mertens F, 2007, PEDIATR BLOOD CANCER, V49, P1015, DOI 10.1002/pbc.20755 Paulino AC, 2003, SEMIN NUCL MED, V33, P238, DOI 10.1053/snuc.2003.127313 Spinou E, 2002, INT J PEDIATR OTORHI, V63, P15, DOI 10.1016/S0165-5876(01)00633-4 NR 15 TC 3 Z9 4 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD AUG PY 2011 VL 120 IS 8 BP 546 EP 549 PG 4 WC Otorhinolaryngology SC Otorhinolaryngology GA 812EG UT WOS:000294273300010 PM 21922980 ER PT J AU Bohnenkamp, TA Forrest, KM Klaben, BK Stager, JM AF Bohnenkamp, Todd A. Forrest, Karen M. Klaben, Bernice K. Stager, Joel M. TI Lung Volumes Used During Speech Breathing in Tracheoesophageal Speakers SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE alaryngeal speech; laryngectomy; respiration ID RESPIRATORY MUSCLE STRENGTH; AIRWAY-RESISTANCE; PULMONARY-FUNCTION; TOTAL LARYNGECTOMY; VOCAL LOUDNESS; OLDER-ADULTS; VOICE; PRESSURE; DISEASE; CANCER AB Objectives: The purpose of this study was to determine how tracheoesophageal (TE) speakers manipulate lung volumes to meet speech demands and how respiratory compromise (chronic obstructive pulmonary disease [COPD] and task variables influence these behaviors. Methods: The lung volumes of 9 male TE speakers (4 with COPD, 5 without) during tidal breathing, spontaneous speech, and reading were investigated. Repeated-measures multivariate analyses of variance were used to compare lung volumes and utterance length across speech tasks and by respiratory health. A one-way analysis of variance was used to compare aerodynamic measures and intelligibility by COPD diagnosis. Results: There was a significant main effect of task and a significant interaction effect of COPD and task on lung volumes at initiation and termination of speech. The TE speakers terminated speech exclusively below the resting expiratory level (REL) in both speech tasks because of elevated RELs, which are often present after laryngectomy. There were no main effects of COPD on any lung volume measures and no significant group differences in utterance length, aerodynamic measures, or intelligibility. Conclusions: Intelligibility and aerodynamic measures were not influenced by lung volumes and were comparable to findings of previous research. Speaking past the REL might be a compensation to optimize expiratory control for speech in a compromised system and a marker for the increased effort often anecdotally described by TE speakers. C1 [Bohnenkamp, Todd A.; Forrest, Karen M.] Indiana Univ, Dept Speech & Hearing Sci, Bloomington, IN 47405 USA. [Stager, Joel M.] Indiana Univ, Sch Hlth Phys Educ & Recreat, Bloomington, IN USA. [Klaben, Bernice K.] Univ Cincinnati, Voice & Swallowing Ctr, Cincinnati, OH USA. RP Bohnenkamp, TA (reprint author), Univ No Iowa, Dept Commun Sci & Disorders, Commun Arts Ctr 21, 1555 W 27th St, Cedar Falls, IA 50614 USA. FU Indiana University Department of Speech and Hearing Sciences FX This study was supported by the Indiana University Department of Speech and Hearing Sciences' Departmental Research Support Program. CR Ackerstaff AH, 1995, CLIN OTOLARYNGOL, V20, P547, DOI 10.1111/j.1365-2273.1995.tb01599.x Ackerstaff AH, 1998, LARYNGOSCOPE, V108, P257, DOI 10.1097/00005537-199802000-00018 [Anonymous], 2002, TF32 TIME FREQUENCY Barlow SM, 1999, HDB CLIN SPEECH PHYS, P175 Berry JK, 1996, NURS RES, V45, P154, DOI 10.1097/00006199-199605000-00006 BODE FR, 1976, J APPL PHYSIOL, V41, P129 Bohnenkamp TA, 2010, J COMMUN DISORD, V43, P199, DOI 10.1016/j.jcomdis.2010.01.003 BRIDGES A, 1991, BRIT J DISORD COMMUN, V26, P325 CHADHA TS, 1982, AM REV RESPIR DIS, V125, P644 *COMM DIS SOFTW, 1996, SENT INT TEST COMP P Eksteen EC, 2003, J OTOLARYNGOL, V32, P250, DOI 10.2310/7070.2003.41731 ENRIGHT PL, 1994, AM J RESP CRIT CARE, V149, P430 Fairbanks G, 1960, VOICE ARTICULATION D FRANK NR, 1957, J CLIN INVEST, V36, P1680, DOI 10.1172/JCI103569 GREGOR RT, 1984, ACTA OTO-LARYNGOL, V97, P177, DOI 10.3109/00016488409130978 Hess MM, 1999, LARYNGOSCOPE, V109, P988, DOI 10.1097/00005537-199906000-00027 HIXON TJ, 1973, J SPEECH HEAR RES, V16, P78 HOLMES LC, 1994, J SPEECH HEAR RES, V37, P789 Huber JE, 2008, J SPEECH LANG HEAR R, V51, P651, DOI 10.1044/1092-4388(2008/047) Huber JE, 2008, RESP PHYSIOL NEUROBI, V164, P323, DOI 10.1016/j.resp.2008.08.007 LEE L, 1993, AM REV RESPIR DIS, V147, P1199 McAuliffe MJ, 2000, ARCH OTOLARYNGOL, V126, P705 MOON JB, 1987, J SPEECH HEAR RES, V30, P387 Motta S, 2001, ARCH OTOLARYNGOL, V127, P700 MURTY GE, 1991, CLIN OTOLARYNGOL, V16, P25, DOI 10.1111/j.1365-2273.1991.tb01937.x Searl J, 2007, ANN OTO RHINOL LARYN, V116, P304 *SEER PROGR, 2002, SURV EP END RES SEER SHARP JT, 1977, AM REV RESPIR DIS, V115, P47 SINGER MI, 1980, ANN OTO RHINOL LARYN, V89, P529 TODISCO T, 1984, RESPIRATION, V45, P303 TOGAWA K, 1980, ARCH OTO-RHINO-LARYN, V229, P69, DOI 10.1007/BF00453753 TOLEP K, 1993, CLIN CHEST MED, V14, P363 Usui N, 1979, Auris Nasus Larynx, V6, P87 Ward E.C., 2007, ASIA PACIFIC J SPEEC, V10, P33 WEINBERG B, 1982, J SPEECH HEAR DISORD, V47, P194 WEINBERG B, 1982, J SPEECH HEAR DISORD, V47, P441 NR 36 TC 1 Z9 1 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD AUG PY 2011 VL 120 IS 8 BP 550 EP 558 PG 9 WC Otorhinolaryngology SC Otorhinolaryngology GA 812EG UT WOS:000294273300011 PM 21922981 ER PT J AU Bhattacharyya, N AF Bhattacharyya, Neil TI Incremental Health Care Utilization and Expenditures for Chronic Rhinosinusitis in the United States SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE chronic rhinosinusitis; cost; health care expenditure; office visit ID CHARLSON COMORBIDITY INDEX; PANEL SURVEY; SINUSITIS; EPIDEMIOLOGY; BURDEN; ASTHMA AB Objectives: T determined incremental increases in health care expenditures and utilization associated with chronic rhinosinusitis (CRS). Methods: Patients with a reported diagnosis of CRS were extracted from the 2007 Medical Expenditure Panel Survey medical conditions file and linked to the consolidated expenditures file. The patients with CRS were then compared to patients without CRS to determine differences in health care utilization (office visits, emergency facility visits, and prescriptions filled), as well as differences in health care expenditures (total health care costs, office visit costs, prescription medication costs, and self-expenditures) by use of demographically adjusted and comorbidity-adjusted multivariate models. Results: An estimated 11.1 +/- 0.48 million adult patients reported having CRS in 2007 (4.9% +/- 0.2% of the US population). The additional incremental health care utilizations associated with CRS relative to patients without CRS for office visits, emergency facility visits, and number of prescriptions filled were 3.45 +/- 0.42, 0.09 +/- 0.03, and 5.5 +/- 0.8, respectively (all p <= 0.001). Similarly, additional health care expenditures associated with CRS for total health care expenses, office-based expenditures, prescription expenditures, and self-expenditures were $772 +/- $300, $346 +/- $130, $397 +/- $88, and $90 +/- $24, respectively (all p <= 0.01). Conclusions: Chronic rhinosinusitis is associated with a substantial incremental increase in health care utilization and expenditures due to increases in office-based and prescription expenditures. The national health care costs of CRS remain very high, at an estimated $8.6 billion per year. C1 [Bhattacharyya, Neil] Brigham & Womens Hosp, Div Otolaryngol, Boston, MA 02115 USA. [Bhattacharyya, Neil] Harvard Univ, Sch Med, Dept Otol & Laryngol, Boston, MA 02115 USA. RP Bhattacharyya, N (reprint author), Brigham & Womens Hosp, Div Otolaryngol, 45 Francis St, Boston, MA 02115 USA. CR Anand VK, 2004, ANN OTO RHINOL LARYN, V113, P3 Balu S, 2006, AM J HYPERTENS, V19, P810, DOI 10.1016/j.amjhyper.2005.12.013 Benninger MS, 2003, OTOLARYNG HEAD NECK, V129, pS1, DOI 10.1016/S0194-5998(03)01397-4 Bhattacharyya N, 2004, ARCH OTOLARYNGOL, V130, P975, DOI 10.1001/archotol.130.8.975 Bhattacharyya N, 2009, AMJ RHINOL ALLERGY, V23, P392, DOI 10.2500/ajra.2009.23.3355 Bhattacharyya N, 2003, AM J RHINOL, V17, P27 DHoore W, 1996, J CLIN EPIDEMIOL, V49, P1429, DOI 10.1016/S0895-4356(96)00271-5 Gliklich RE, 1998, OTOLARYNG HEAD NECK, V118, P344, DOI 10.1016/S0194-5998(98)70313-4 Halpern MT, 2008, CANCER INVEST, V26, P647, DOI 10.1080/07357900801905519 Kamble S, 2009, J ASTHMA, V46, P73, DOI 10.1080/02770900802503107 Needham DM, 2005, J CRIT CARE, V20, P12, DOI 10.1016/j.jcrc.2004.09.007 Ray NF, 1999, J ALLERGY CLIN IMMUN, V103, P408, DOI 10.1016/S0091-6749(99)70464-1 Smith WM, 2009, OTOLARYNG HEAD NECK, V141, P347, DOI 10.1016/j.otohns.2009.05.021 Vaithianathan R, 2009, DRUG SAFETY, V32, P335, DOI 10.2165/00002018-200932040-00007 Ward MM, 2000, INT J TECHNOL ASSESS, V16, P125, DOI 10.1017/S0266462300161112 Zuvekas SH, 2009, HEALTH SERV RES, V44, P1679, DOI 10.1111/j.1475-6773.2009.00995.x NR 16 TC 62 Z9 63 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD JUL PY 2011 VL 120 IS 7 BP 423 EP 427 PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA 795DK UT WOS:000292951500001 PM 21859049 ER PT J AU Stamatiou, GA Kyrodimos, E Sismanis, A AF Stamatiou, Georgios A. Kyrodimos, Efthimios Sismanis, Aristides TI Complications of Cochlear Implantation in Adults SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article; Proceedings Paper CT Joint Meeting of the 4th Consensus in Auditory Implants/5th European-Academy-of-Otology-and-Neuro-Otology Instructional Workshop CY JUN 16-19, 2010 CL Parma, ITALY SP European Acad Otol & Neuro Otol DE adult; cochlear implantation; complication ID SURGICAL COMPLICATIONS; DEVICE FAILURE; REVISION; SURGERY; MANAGEMENT; CHILDREN; INFECTIONS; EXPERIENCE; HEMATOMA AB Objectives: We describe our experience of intraoperative and postoperative complications of cochlear implantation in an adult population. Methods: Between April 1986 and June 2010, the senior author (A.S.) performed 449 cochlear implantations in two different institutions. Of these, 212 implantations were in adults. The operative techniques were similar in all cases. Results: Complications were observed in 12 of the 212 adult cases (5.7%), of which 10 were major (4.7%) and 2 minor (1%). In 7 cases, reimplantation was necessitated by device failure (6 cases; 2.8%) or device extrusion (I case; 0.5%). In 2 elderly patients (1%), a minor dural injury with a cerebrospinal fluid leak was controlled during the operation with temporalis fascia grafting. In 1 patient (0.5%), a subdural hematoma was observed after bipolar cauterization of a prominent diploic vein. In 2 subjects (1%), a wound infection was noted soon after implantation and was treated successfully on an outpatient basis. Conclusions: Cochlear implantation is generally a safe procedure. The most common complication was device failure. Although complications in this adult population were rather uncommon, some of them were serious, and an immediate intervention was necessary for a successful outcome. C1 [Stamatiou, Georgios A.; Kyrodimos, Efthimios; Sismanis, Aristides] Univ Athens, Hippokrat Gen Hosp, Dept Otolaryngol Head & Neck Surg, Athens, Greece. RP Stamatiou, GA (reprint author), 3 Nikolaou Plastira St, Athens 15121, Greece. CR [Anonymous], 2005, OTOL NEUROTOL, V26, P1097 Arnoldner C, 2005, ACTA OTO-LARYNGOL, V125, P228, DOI 10.1080/00016480410022895 Battmer RD, 2009, OTOL NEUROTOL, V30, P455, DOI 10.1097/MAO.0b013e31819e6206 Battmer RD, 2007, EAR HEARING, V28, p95S, DOI 10.1097/AUD.0b013e3180315502 Bhatia K, 2004, OTOL NEUROTOL, V25, P730, DOI 10.1097/00129492-200409000-00015 Biernath KR, 2006, PEDIATRICS, V117, P284, DOI 10.1542/peds.2005-0824 Brown KD, 2009, LARYNGOSCOPE, V119, P152, DOI 10.1002/lary.20012 Buchman CA, 2004, OTOL NEUROTOL, V25, P504, DOI 10.1097/00129492-200407000-00018 COHEN NL, 1988, ANN OTO RHINOL LARYN, V97, P8 Cote M, 2007, LARYNGOSCOPE, V117, P1225, DOI 10.1097/MLG.0b013e31805c9a06 Cunningham CD, 2004, OTOLARYNG HEAD NECK, V131, P109, DOI 10.1016/j.othons.2004.02.011 Dodson KM, 2007, OTOL NEUROTOL, V28, P459, DOI 10.1097/mao.0b013e31802fba94 Dutt SN, 2005, J LARYNGOL OTOL, V119, P759 Fayad JN, 2004, OTOLARYNG HEAD NECK, V131, P429, DOI 10.1016/j.otohns.2004.03.033 Gosepath J, 2005, OTOL NEUROTOL, V26, P202, DOI 10.1097/00129492-200503000-00012 Green KMJ, 2004, J LARYNGOL OTOL, V118, P417 Hirsch BE, 2007, LARYNGOSCOPE, V117, P864, DOI 10.1097/MLG.0b013e318033c2f9 Kempf H G, 2000, Ann Otol Rhinol Laryngol Suppl, V185, P25 Lassig AAD, 2005, OTOL NEUROTOL, V26, P624, DOI 10.1097/01.mao.0000178123.35988.96 Ovesen T, 2009, J LARYNGOL OTOL, V123, P492, DOI 10.1017/S0022215108003691 Proops D W, 1999, J Laryngol Otol Suppl, V24, P14 Ray Jaydip, 2004, Cochlear Implants Int, V5, P160, DOI 10.1002/cii.143 Rivas A, 2008, OTOL NEUROTOL, V29, P639, DOI 10.1097/MAO.0b013e31817e5d31 Rubinstein JT, 1999, AM J OTOL, V20, P46 Sorrentino T, 2009, ACTA OTO-LARYNGOL, V129, P380, DOI 10.1080/00016480802552576 Sunkaraneni VS, 2004, J LARYNGOL OTOL, V118, P980 Trotter M I, 2009, Cochlear Implants Int, V10 Suppl 1, P105, DOI 10.1002/cii.400 Venail F, 2008, ARCH OTOLARYNGOL, V134, P1276, DOI 10.1001/archoto.2008.504 Yu KCY, 2001, OTOLARYNG HEAD NECK, V125, P66, DOI 10.1067/mhn.2001.116444 NR 29 TC 6 Z9 6 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD JUL PY 2011 VL 120 IS 7 BP 428 EP 432 PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA 795DK UT WOS:000292951500002 PM 21859050 ER PT J AU Hurtuk, A Dome, C Holloman, CH Wolfe, K Welling, DB Dodson, EE Jacob, A AF Hurtuk, Agnes Dome, Claudia Holloman, Christopher H. Wolfe, Kelly Welling, D. Bradley Dodson, Edward E. Jacob, Abraham TI Melatonin: Can It Stop the Ringing? SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article; Proceedings Paper CT American Otological-Society-Spring-Meeting CY MAY 01-02, 2010 CL Las Vegas, NV SP Amer Otolog Soc DE melatonin; tinnitus ID SLEEP QUALITY; TINNITUS; PROTECTION; MECHANISMS; MOOD AB Objectives: We sought to report the efficacy of oral melatonin as treatment for chronic tinnitus and to determine whether particular subsets of tinnitus patients have greater benefit from melatonin therapy than others. Methods: This was a prospective, randomized, double-blind, crossover clinical trial in an ambulatory tertiary referral otology and neurotology practice. Adults with chronic tinnitus were randomized to 3 mg melatonin or placebo nightly for 30 days followed by a 1-month washout period. Each group then crossed into the opposite treatment arm for 30 days. The tests audiometric tinnitus matching (TM), Tinnitus Severity Index (TSI), Self Rated Tinnitus (SRT), Pittsburgh Sleep Quality Index (PSQI), and Beck Depression Inventory (BDI) were administered at the outset and every 30 days thereafter to assess the effects of each intervention. Results: A total of 61 subjects completed the study. A significantly greater decrease in TM and SRT scores (p < 0.05) from baseline was observed after treatment with melatonin relative to the effect observed with placebo. Male gender, bilateral tinnitus, noise exposure, no prior tinnitus treatment, absence of depression and/or anxiety at baseline, and greater pretreatment TSI scores were associated with a positive response to melatonin. Absence of depression and/or anxiety at baseline, greater pretreatment TSI scores, and greater pretreatment SRT scores were found to be positively associated with greater likelihood of improvement in both tinnitus and sleep with use of melatonin (p < 0.05). Conclusions: Melatonin is associated with a statistically significant decrease in tinnitus intensity and improved sleep quality in patients with chronic tinnitus. Melatonin is most effective in men, those without a history of depression, those who have not undergone prior tinnitus treatments, those with more severe and bilateral tinnitus, and those with a history of noise exposure. C1 [Hurtuk, Agnes; Dome, Claudia; Wolfe, Kelly; Welling, D. Bradley; Dodson, Edward E.; Jacob, Abraham] Ohio State Univ, Inst Eye & Ear, Dept Otolaryngol Head & Neck Surg, Columbus, OH 43212 USA. [Holloman, Christopher H.] Ohio State Univ, Dept Stat, Columbus, OH 43212 USA. RP Jacob, A (reprint author), Ohio State Univ, Inst Eye & Ear, Dept Otolaryngol Head & Neck Surg, 915 Olentangy River Rd,Suite 4000, Columbus, OH 43212 USA. CR ALDHOUS M, 1985, BRIT J CLIN PHARMACO, V19, P517 Asplund R, 2003, ARCH GERONTOL GERIAT, V37, P139, DOI 10.1016/S0167-4943(03)00028-1 Attenburrow MEJ, 1996, PSYCHOPHARMACOLOGY, V126, P179, DOI 10.1007/BF02246354 Bas E, 2009, ACTA OTO-LARYNGOL, V129, P385, DOI 10.1080/00016480802566279 Bauer CA, 2006, LARYNGOSCOPE, V116, P675, DOI 10.1097/01.MLG.0000216812.65206.CD BECK AT, 1961, ARCH GEN PSYCHIAT, V4, P561 BUYSSE DJ, 1989, PSYCHIAT RES, V28, P193, DOI 10.1016/0165-1781(89)90047-4 Dineen R, 1997, BRIT J AUDIOL, V31, P331, DOI 10.3109/03005364000000027 Folmer R. L., 2002, BMC EAR NOSE THROAT, V2, P3, DOI DOI 10.1186/1472-6815-2-3 Hardeland R, 2005, ENDOCRINE, V27, P119, DOI 10.1385/ENDO:27:2:119 Henry J A, 2000, Am J Audiol, V9, P36, DOI 10.1044/1059-0889(2000/002) Imbesi M., 2006, INT J NEUROPROTECT N, V2, P185 Kim JB, 2009, CLIN EXP OTORHINOLAR, V2, P6, DOI 10.3342/ceo.2009.2.1.6 LANE EA, 1985, J CLIN ENDOCR METAB, V61, P1214 Leppamaki S, 2003, EUR NEUROPSYCHOPHARM, V13, P137, DOI 10.1016/S0924-977X(02)00175-X Lopez-Gonzalez MA, 2007, J OTOLARYNGOL, V36, P213, DOI 10.2310/7070.2007.0018 Megwalu UC, 2006, OTOLARYNG HEAD NECK, V134, P210, DOI 10.1016/j.otohns.2005.10.007 MEIKLE MB, 1992, TINNITUS 91, P555 Mitchell C R, 1993, J Am Acad Audiol, V4, P139 Muhr P, 2010, INT J AUDIOL, V49, P317, DOI 10.3109/14992020903431280 Neri G, 2009, ACTA OTORHINOLARYNGO, V29, P86 Paulis L, 2007, PHYSIOL RES, V56, P671 PENNER MJ, 1992, EAR HEARING, V13, P410, DOI 10.1097/00003446-199212000-00007 Pires MLN, 2001, J PINEAL RES, V31, P326, DOI 10.1034/j.1600-079X.2001.310407.x Pirodda A, 2010, MED HYPOTHESES, V75, P190, DOI 10.1016/j.mehy.2010.02.018 Rosenberg SI, 1998, LARYNGOSCOPE, V108, P305, DOI 10.1097/00005537-199803000-00001 Simko F, 2007, J PINEAL RES, V42, P319, DOI 10.1111/j.1600-079X.2007.00436.x WALDHAUSER F, 1984, NEUROENDOCRINOLOGY, V39, P307, DOI 10.1159/000123997 WEHR T, 1979, CHRONOBIOLOGIA, V6, P377 NR 29 TC 12 Z9 12 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD JUL PY 2011 VL 120 IS 7 BP 433 EP 440 PG 8 WC Otorhinolaryngology SC Otorhinolaryngology GA 795DK UT WOS:000292951500003 PM 21859051 ER PT J AU Crowell, ES Givens, GD Jones, GL Brechtelsbauer, PB Yao, JC AF Crowell, Ellen S. Givens, Gregg D. Jones, Gloria L. Brechtelsbauer, P. Bradley Yao, Jianchu TI Audiology Telepractice in a Clinical Environment: A Communication Perspective SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE audiology; otolaryngology; telemedicine ID REMOTE; TELEMEDICINE; TELEHEALTH; DISORDERS AB Access to adequate hearing health care is an obstacle that many individuals face worldwide. The prospect of providing audiology services via the Internet is an attractive and viable alternative to traditional face-to-face interaction between patients and audiologists, thus affording improved access to hearing health care for traditionally underserved populations. This article details our experience of using a web-based system with wireless audiometers and videoconferencing software to administer remote audiological assessments in an active medical practice. It discusses the technological infrastructure used and the pragmatic issues that arise when the Internet, Bluetooth wireless audiometers, and videoconferencing devices are converged into a clinical setting. Patients at a local office of otolaryngologists were recruited to participate in a study in which remote assessment results were compared to those collected from a traditional face-to-face assessment. Preliminary data demonstrated that the assessment results from the two sources were comparable. We conclude that remote hearing assessment over the Internet can be achieved through a distributed system synthesized with Internet, wireless communication, and videoconferencing technologies, supported by appropriate staff. C1 [Crowell, Ellen S.; Givens, Gregg D.] E Carolina Univ, Coll Allied Hlth Sci, Dept Commun Sci & Disorders, Greenville, NC 27834 USA. [Jones, Gloria L.] E Carolina Univ, Brody Sch Med, Telemed Ctr, Greenville, NC 27834 USA. [Yao, Jianchu] E Carolina Univ, Dept Engn, Coll Technol & Comp Sci, Greenville, NC 27834 USA. [Brechtelsbauer, P. Bradley] Eastern Carolina ENT Head & Neck Surg, Greenville, NC USA. RP Givens, GD (reprint author), E Carolina Univ, Coll Allied Hlth Sci, Dept Commun Sci & Disorders, Greenville, NC 27834 USA. CR *AM SPEECH LANG HE, 2005, AUD PROV CLIN SERV V Burgiss S G, 1997, Telemed J, V3, P227, DOI 10.1089/tmj.1.1997.3.227 Choi JM, 2007, TELEMED J E-HEALTH, V13, P501, DOI 10.1089/tmj.2007.0085 Crowe B L, 1996, J Telemed Telecare, V2, P210, DOI 10.1258/1357633961930095 Eikelboom RH, 2005, INT J PEDIATR OTORHI, V69, P739, DOI 10.1016/j.ijporl.2004.12.008 Elangovan Saravanan, 2005, Seminars in Hearing, V26, P19, DOI 10.1055/s-2005-863791 Elkateeb A, 2001, TELEMED J E-HEALTH, V7, P233, DOI 10.1089/153056201316970939 Franck K., 2006, VOLTA VOICES, V13, P16 Givens Gregg D, 2003, Am J Audiol, V12, P59, DOI 10.1044/1059-0889(2003/011) Krumm Mark, 2005, Seminars in Hearing, V26, P3, DOI 10.1055/s-2005-863789 Krumm M, 2008, J TELEMED TELECARE, V14, P102, DOI 10.1258/jtt.2007.070612 Krumm M, 2007, J TELEMED TELECARE, V13, P406, DOI 10.1258/135763307783064395 Kully D, 2000, J TELEMED TELECARE, V6, P39, DOI 10.1258/1357633001935509 Lancaster P, 2008, AM J AUDIOL, V17, P114, DOI 10.1044/1059-0889(2008/07-0008) McLaren P M, 1996, J Telemed Telecare, V2, P57, DOI 10.1258/1357633961929178 POLOVOY C, 2008, ASHA LEADER, V13, P20 Ramos A, 2009, ACTA OTO-LARYNGOL, V129, P533, DOI 10.1080/00016480802294369 Ribera John E., 2005, Seminars in Hearing, V26, P13, DOI 10.1055/s-2005-863790 Ruskin PE, 2004, AM J PSYCHIAT, V161, P1471, DOI 10.1176/appi.ajp.161.8.1471 Theodoros D, 2008, TELEMED J E-HEALTH, V14, P552, DOI 10.1089/tmj.2007.0091 Towers Andrew D., 2005, Seminars in Hearing, V26, P26, DOI 10.1055/s-2005-863792 Waite MC, 2006, J TELEMED TELECARE, V12, P92, DOI 10.1258/135763306779380048 WHO, 2006, PRIM EAR HEAR CAR TR Yao JC, 2009, TELEMED J E-HEALTH, V15, P777, DOI 10.1089/tmj.2009.0031 Yao JC, 2010, J CLIN MONIT COMPUT, V24, P41, DOI 10.1007/s10877-009-9208-6 NR 25 TC 1 Z9 1 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD JUL PY 2011 VL 120 IS 7 BP 441 EP 447 PG 7 WC Otorhinolaryngology SC Otorhinolaryngology GA 795DK UT WOS:000292951500004 PM 21859052 ER PT J AU Briggs, L Davidson, L Lieu, JEC AF Briggs, Lauren Davidson, Lisa Lieu, Judith E. C. TI Outcomes of Conventional Amplification for Pediatric Unilateral Hearing Loss SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE child; hearing aid; quality of life; speech perception; unilateral hearing loss ID CHILDREN; IMPAIRMENT AB Objectives: Although children with unilateral hearing loss (UHL) are at risk for educational difficulties and behavioral problems, the research on treatment outcomes is limited. Previous studies suggested that children with UHL would benefit from frequency-modulated assistive devices only. The objective of this study was to examine whether children with UHL would benefit from using a conventional hearing aid in the poorer-hearing ear. Methods: Eight children, 7 to 12 years of age, with mild to moderately severe UHL and their parents and teachers participated in this study. The participants were fitted with digital hearing aids by use of pediatric prescriptive targets. The primary outcome measures were speech perception tests in quiet and noise and subjective assessments from participants, parents, and teachers, administered before hearing aid fitting and after 3 months of hearing aid use. Results: The group average speech perception scores showed no significant aided benefit or detriment in any of the conditions tested. However, subjective assessments showed large significant aided benefits at home and school according to the children and their parents, and in quality of life as reported by the children with UHL. Conclusions: Overall, the results suggest that a hearing aid trial should be considered for children with mild to moderately severe UHL, with individual monitoring for benefit. C1 [Briggs, Lauren] Washington Univ, Sch Med, Program Audiol & Commun Sci, St Louis, MO USA. [Davidson, Lisa; Lieu, Judith E. C.] Washington Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, St Louis, MO 63110 USA. RP Lieu, JEC (reprint author), 660 S Euclid Ave,Campus Box 8115, St Louis, MO 63110 USA. FU National Center for Research Resources [NCRR], a component of the National Institutes of Health [NIH] [UL1 RR024992]; NIH Roadmap for Medical Research; National Institute on Deafness and Other Communication Disorders (NIDCD) [K23 DC006638] FX From the Program of Audiology and Communication Sciences (Briggs) and the Department of Otolaryngology Head and Neck Surgery (Davidson, Lieu), Washington University School of Medicine. St Louis, Missouri. This study was supported by a Barnes-Jewish Hospital Foundation/Washington University Institute of Clinical and Translational Sciences grant (UL1 RR024992 from the National Center for Research Resources [NCRR], a component of the National Institutes of Health [NIH], and NIH Roadmap for Medical Research) and by the National Institute on Deafness and Other Communication Disorders (NIDCD; K23 DC006638). Its contents are solely the responsibility of the authors and do not necessarily represent the official view of the NCRR, NIDCD, or NIH. The hearing aids used in this study were provided by the Oticon Pediatrics Research Initiative. CR Anderson K. L., 1996, SCREENING INSTRUMENT Anderson KL, 1998, LISTENING INVENTORY Anderson KL, 2000, CHILDRENS HOME INVEN BESS FH, 1984, PEDIATRICS, V74, P206 Borton SA, 2010, AM J AUDIOL, V19, P61, DOI [10.1044/1059-0889(2010/07-0043), 10.1044/1059-0889(2010/07-0043] Bovo R, 1988, Scand Audiol Suppl, V30, P71 Davis A., 2002, SOUND FDN EARLY AMPL, P179 EDGERTON B, 1979, CLIN IMPLICATIONS SP *ET RES, 2005, ET RES BAMF KOW BENC KENWORTHY OT, 1990, EAR HEARING, V11, P264, DOI 10.1097/00003446-199008000-00003 Kiese-Himmel C, 2000, HNO, V48, P758, DOI 10.1007/s001060050655 Kiese-Himmel C, 2002, INT J AUDIOL, V41, P57, DOI 10.3109/14992020209101313 Lieu JEC, 2004, ARCH OTOLARYNGOL, V130, P524, DOI 10.1001/archotol.130.5.524 MCKAY S, 2002, HLTH HEARING NORTHERN J, 1978, HEARING CHILDREN, P143 Oyler R.F., 1988, LANG SPEECH HEAR SER, V19, P201 Streufert AM, 2008, THESIS WASHINGTON U Updike C D, 1994, J Am Acad Audiol, V5, P204 NR 18 TC 4 Z9 4 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD JUL PY 2011 VL 120 IS 7 BP 448 EP 454 PG 7 WC Otorhinolaryngology SC Otorhinolaryngology GA 795DK UT WOS:000292951500005 PM 21859053 ER PT J AU Zhou, HB Zou, BM Hazucha, M Carson, JL AF Zhou, Haibo Zou, Baiming Hazucha, Milan Carson, Johnny L. TI Nasal Nitric Oxide and Lifestyle Exposure to Tobacco Smoke SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE inflammation; nitric oxide; secondhand smoke; tobacco smoke ID CILIARY BEAT FREQUENCY; LOCALLY WEIGHTED REGRESSION; MUCOCILIARY ACTIVITY; STIMULATION; DYSKINESIA; MODULATION; SYNTHASE; MUCOSA; RABBIT; COPD AB Objectives: Nitric oxide (NO) is a reactive gas generated by inflammatory cells and mucosal epithelial cells of the nose and paranasal sinuses and is an important mediator in nonspecific host defense against infectious agents. However, NO also mediates physiologic events such as vasodilation, mucus hypersecretion, and mucosal disruption that are associated with inflammatory conditions, and it is a regulator of ciliary beat frequency. In the present study, we hypothesized that lifestyle exposure to tobacco smoke, whether through active smoking or by inadvertent exposure to secondhand tobacco smoke, would result in higher detectable levels of nasal NO (nNO) than are found in well-documented nonsmokers. Methods: Nasal NO measurements were obtained concomitant with assays of urine cotinine from well-documented nonsmokers, active smokers, and individuals exposed by lifestyle to secondhand smoke. These parameters were statistically analyzed to determine whether increasing levels of tobacco smoke exposure yield higher concentrations of nNO. Results: Our results and subsequent statistical analyses imply that active smokers who exhibit high urine cotinine levels exhibit significant increases in nNO levels in comparison to both nonsmokers and nonsmokers exposed to secondhand smoke. Conclusions: There is an increased level of nNO associated with tobacco smoke exposure that may contribute to the inflammatory processes characteristic of disease pathogenesis in smokers. C1 [Zhou, Haibo; Zou, Baiming; Hazucha, Milan; Carson, Johnny L.] Univ N Carolina, Ctr Environm Med Asthma & Lung Biol, Chapel Hill, NC 27599 USA. [Zhou, Haibo; Zou, Baiming] Univ N Carolina, Dept Biostat, Chapel Hill, NC 27599 USA. [Carson, Johnny L.] Univ N Carolina, Dept Pediat, Chapel Hill, NC 27599 USA. RP Carson, JL (reprint author), Univ N Carolina, Ctr Environm Med Asthma & Lung Biol, Chapel Hill, NC 27599 USA. FU National Institutes of Health [R01CA79949]; Flight Attendant Medical Research Institute; US Environmental Protection Agency [CR833463-01]; Center for Environmental Medicine, Asthma, and Lung Biology at the University of North Carolina at Chapel Hill FX From the Center for Environmental Medicine, Asthma, and Lung Biology (all authors), the Department of Biostatistics (Zhou, Zou), and the Department of Pediatrics (Carson), The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina. This study was supported by grant R01CA79949 from the National Institutes of Health (H.Z.), a Clinical Innovator Award from the Flight Attendant Medical Research Institute (J.L.C.), and the US Environmental Protection Agency. Although the research described in this article has been funded wholly or in part by the US Environmental Protection Agency through cooperative agreement CR833463-01 with the Center for Environmental Medicine, Asthma, and Lung Biology at the University of North Carolina at Chapel Hill, it has not been subjected to the agency's required peer and policy review, and therefore does not necessarily reflect the views of the agency, and no official endorsement should be inferred. Mention of trade names or commercial products does not constitute endorsement or recommendation for use. CR Alberty J, 2004, LARYNGOSCOPE, V114, P1642, DOI 10.1097/00005537-200409000-00026 Baraldo S, 2004, THORAX, V59, P308, DOI 10.1136/thx.2003.012146 Broekema M, 2009, AM J RESP CRIT CARE, V180, P1170, DOI 10.1164/rccm.200906-0828OC CLEVELAND WS, 1979, J AM STAT ASSOC, V74, P829, DOI 10.2307/2286407 CLEVELAND WS, 1988, J AM STAT ASSOC, V83, P596, DOI 10.2307/2289282 Debats IBJG, 2009, NITRIC OXIDE-BIOL CH, V21, P175, DOI 10.1016/j.niox.2009.07.006 Furukawa K, 1996, AM J RESP CRIT CARE, V153, P847 IGNARRO LJ, 1987, CIRC RES, V61, P866 JAIN B, 1993, BIOCHEM BIOPH RES CO, V191, P83, DOI 10.1006/bbrc.1993.1187 Kinnula VL, 2007, EUR RESPIR J, V29, P51, DOI 10.1183/09031936.00023606 KOBZIK L, 1993, AM J RESP CELL MOL, V9, P371 LINDBERG S, 1986, EUR J RESPIR DIS, V68, P96 LINDBERG S, 1986, B EUR PHYSIOPATH RES, V22, P273 Marthin JK, 2011, EUR RESPIR J, V37, P559, DOI 10.1183/09031936.00032610 Masri F, 2010, ANN THORAC MED, V5, P123, DOI 10.4103/1817-1737.65036 MONCADA S, 1991, PHARMACOL REV, V43, P109 Noone PG, 2004, AM J RESP CRIT CARE, V169, P459, DOI 10.1164/rccm.200303-365OC Pavord ID, 2008, J ASTHMA, V45, P523, DOI 10.1080/02770900801978557 PERSSON MG, 1994, LANCET, V343, P146, DOI 10.1016/S0140-6736(94)90935-0 S. American Thoracic and S. European Respiratory, 2005, AM J RESP CRIT CARE, V171, P912 TAMAOKI J, 1995, AM J PHYSIOL-CELL PH, V268, pC1342 Taylor DR, 2006, THORAX, V61, P817, DOI 10.1136/thx.2005.056093 Yang B, 1997, ANN OTO RHINOL LARYN, V106, P230 Zhou HB, 2009, INHAL TOXICOL, V21, P875, DOI 10.1080/08958370802555898 NR 24 TC 3 Z9 3 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD JUL PY 2011 VL 120 IS 7 BP 455 EP 459 PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA 795DK UT WOS:000292951500006 PM 21859054 ER PT J AU De Stefano, A Dispenza, F Citraro, L Petrucci, AG Di Giovanni, P Kulamarva, G Mathur, N Croce, A AF De Stefano, Alessandro Dispenza, Francesco Citraro, Leonardo Petrucci, Anna Grazia Di Giovanni, Pamela Kulamarva, Gautham Mathur, Navneet Croce, Adelchi TI Are Postural Restrictions Necessary For Management of Posterior Canal Benign Paroxysmal Positional Vertigo? SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE BPPV; benign paroxysmal positional vertigo; Epley maneuver; posterior canal vertigo; postural restriction; Semont maneuver; vertigo ID REPOSITIONING PROCEDURE; MANEUVER AB Objectives: An important component of management of benign paroxysmal positional vertigo (BPPV) has been the application of postural restrictions after use of a canalith repositioning maneuver (CRM) to prevent the return of otolithic debris into the posterior semicircular canal (PSC). This study was designed to explore the effectiveness of postural restrictions in patients with BPPV caused by otolithic debris in the PSC. Methods: Seventy-four adult patients with unilateral PSC BPPV were enrolled into this study. All patients were managed with a CRM either the modified Epley maneuver or the Semont maneuver. The patients were divided randomly into 2 groups: group A. with postural restrictions, and group B, without postural restrictions. The statistical analysis was performed with chi(2) tests and t-tests. Results: No patients in either group showed positional nystagmus in the posttreatment evaluation under infrared videonystagmoscopy. No patients had symptoms of vertigo after the therapy. The results of follow-up vestibular tests were normal in both groups. Conclusions: In our experience, postural restrictions do not enhance the beneficial effect of the CRMs. They do not seem to have any protective role and therefore should not be recommended as an adjunct to the treatment of PSC BPPV. Key Words: BPPV, benign paroxysmal positional vertigo, Epley maneuver, posterior canal vertigo, postural restriction. C1 [De Stefano, Alessandro; Citraro, Leonardo; Croce, Adelchi] G dAnnunzio Univ Chieti Pescara, Ear Nose & Throat Inst, Dept Surg Clin & Expt Sci, Chieti, Italy. [Petrucci, Anna Grazia] G dAnnunzio Univ Chieti Pescara, Postgrad Sch Publ Hlth & Prevent Med, Chieti, Italy. [Di Giovanni, Pamela] G dAnnunzio Univ Chieti Pescara, Dept Drug Sci, Chieti, Italy. [Dispenza, Francesco] Univ Palermo, Ear Nose & Throat Inst, Palermo, Italy. [Kulamarva, Gautham] Kasaragod Inst Med Sci, Ear Nose & Throat Clin, Kasaragod, India. [Mathur, Navneet] Rabindra Nath Tagore Med Coll, Udaipur, India. RP De Stefano, A (reprint author), G dAnnunzio Univ Chieti Pescara, Ear Nose & Throat Inst, Via F Di Palma, I-74100 Taranto, Italy. CR Cakir BO, 2006, ARCH OTOLARYNGOL, V132, P501, DOI 10.1001/archotol.132.5.501 Casqueiro JC, 2008, OTOL NEUROTOL, V29, P706, DOI 10.1097/MAO.0b013e31817d01e8 De Stefano A, 2008, J OTOLARYNGOL-HEAD N, V37, pE46, DOI 10.2310/7070.2008.E0018 Devaiah AK, 2010, OTOLARYNG HEAD NECK, V142, P155, DOI 10.1016/j.otohns.2009.09.013 DIX MR, 1952, P ROY SOC MED, V45, P341 EPLEY JM, 1992, OTOLARYNG HEAD NECK, V107, P399 Fyrmpas G, 2009, AURIS NASUS LARYNX, V36, P637, DOI 10.1016/j.anl.2009.04.004 Ganança Fernando Freitas, 2005, Braz J Otorhinolaryngol, V71, P764 HABERKAMP TJ, 2001, OPER TECH OTOLARYNGO, V12, P151, DOI 10.1016/S1043-1810(01)80011-7 HALL SF, 1979, J OTOLARYNGOL, V8, P151 HAMID M, 2001, OPER TECH OTOLARYNGO, V12, P148, DOI 10.1016/S1043-1810(01)80010-5 HARVEY SA, 1994, LARYNGOSCOPE, V104, P1206 HERDMAN SJ, 1993, ARCH OTOLARYNGOL, V119, P450 Herdman SJ, 1997, PHYS THER, V77, P602 Labuguen RH, 2006, AM FAM PHYSICIAN, V73, P244 Marciano E, 2002, EUR ARCH OTO-RHINO-L, V259, P262, DOI 10.1007/s00405-001-0445-7 Massoud EAS, 1996, J OTOLARYNGOL, V25, P121 MCCLURE JA, 1985, J OTOLARYNGOL, V14, P30 Moon SJ, 2005, EUR ARCH OTO-RHINO-L, V262, P408, DOI 10.1007/s00405-004-0836-7 Motamed M, 2004, LARYNGOSCOPE, V114, P1296, DOI 10.1097/00005537-200407000-00029 JACOBSON GP, 1990, ARCH OTOLARYNGOL, V116, P424 Nunez RA, 2000, OTOLARYNG HEAD NECK, V122, P647, DOI 10.1016/S0194-5998(00)70190-2 PARNES LS, 1993, ANN OTO RHINOL LARYN, V102, P325 Roberts Richard A, 2005, J Am Acad Audiol, V16, P357, DOI 10.3766/jaaa.16.6.4 SCHUKNEC.HF, 1969, ARCH OTOLARYNGOL, V90, P765 SCHUKNECHT H F, 1962, Trans Am Acad Ophthalmol Otolaryngol, V66, P319 Semont A, 1988, Adv Otorhinolaryngol, V42, P290 Simoceli Lucinda, 2005, Braz J Otorhinolaryngol, V71, P55 VITAL V, 2006, MEDITERR J OTOL, V3, P98 Welling DB, 1997, LARYNGOSCOPE, V107, P90, DOI 10.1097/00005537-199701000-00018 Yimtae K, 2003, LARYNGOSCOPE, V113, P828, DOI 10.1097/00005537-200305000-00011 NR 31 TC 8 Z9 8 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD JUL PY 2011 VL 120 IS 7 BP 460 EP 464 PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA 795DK UT WOS:000292951500007 PM 21859055 ER PT J AU Tanner, K Roy, N Merrill, RM Sauder, C Houtz, DR Smith, ME AF Tanner, Kristine Roy, Nelson Merrill, Ray M. Sauder, Cara Houtz, Daniel R. Smith, Marshall E. TI Spasmodic Dysphonia: Onset, Course, Socioemotional Effects, and Treatment Response SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE ansa cervicalis reinnervation; Botox; botulinum toxin A; recurrent laryngeal nerve denervation; spasmodic dysphonia; voice disorder; Voice-Related Quality of Life; V-RQOL ID ESSENTIAL VOICE TREMOR; LIFE V-RQOL; ADDUCTOR DENERVATION-REINNERVATION; LARYNGEAL NERVE RESECTION; MUSCLE TENSION DYSPHONIA; SPASTIC DYSPHONIA; GENERAL-POPULATION; RISK-FACTORS; FOLLOW-UP; DISORDERS AB Objectives: This investigation explored the onset, progression, socioemotional effects, and treatment outcomes of spasmodic dysphonia (SD). Methods: A cross-sectional epidemiological approach was used to examine questionnaire responses from 150 individuals with SD. Results: Symptoms of SD (mean age at onset, 46 years) began gradually in 76% of cases and were progressive (ie, failed to plateau) in 34% of cases. Botulinum toxin A (Botox) helped to attenuate voice symptoms in 91% of cases; however, the scores on the Voice-Related Quality of Life questionnaire (V-RQOL) were not associated with this effect. The V-RQOL scores improved with time since symptom onset, independent of age and treatment. The patients with only SD experienced onset, course, and progression of symptoms similar to those of the patients with SD and coexisting vocal tremor. Conclusions: The symptoms of SD begin gradually and worsen over time. New evidence indicates that SD symptoms may continue to progress without plateau in at least a subset of patients. Individuals with SD and coexisting vocal tremor experience symptom trajectories similar to those of patients with SD only. Although Botox may attenuate voice symptoms, these effects do not appear to be strongly related to the V-RQOL scores. These results provide new and valuable insights regarding the onset, course, progression, and treatment of SD. C1 [Tanner, Kristine] Univ Utah, Voice Disorders Ctr, Surg Specialty Ctr, Dept Commun Sci & Disorders, Salt Lake City, UT 84108 USA. [Tanner, Kristine; Roy, Nelson; Smith, Marshall E.] Univ Utah, Div Otolaryngol Head & Neck Surg, Salt Lake City, UT 84108 USA. [Merrill, Ray M.] Brigham Young Univ, Dept Hlth Sci, Provo, UT 84602 USA. RP Tanner, K (reprint author), Univ Utah, Voice Disorders Ctr, Surg Specialty Ctr, Dept Commun Sci & Disorders, 729 Arapeen Dr, Salt Lake City, UT 84108 USA. FU University of Utah College of Health Research and Creative FX From the Department of Communication Sciences and Disorders (Tanner, Roy), the Division of Otolaryngology Head and Neck Surgery (Tanner, Roy, Smith), and the Voice Disorders Center (Sauder, Houtz), The University of Utah, Salt Lake City, and the Department of Health Science, Brigham Young University, Provo (Merrill), Utah. This work was supported in part by a University of Utah College of Health Research and Creative Grant. CR Allegretto M, 2003, J OTOLARYNGOL, V32, P185, DOI 10.2310/7070.2003.40431 ARONSON AE, 1983, LARYNGOSCOPE, V93, P1 ARONSON AE, 1981, J SPEECH HEAR DISORD, V46, P52 Aronson AE, 1990, CLIN VOICE DISORDERS ARONSON AE, 1968, J SPEECH HEAR DISORD, V33, P219 Benninger MS, 2001, ARCH OTOLARYNGOL, V127, P1083 Berke GS, 1999, ANN OTO RHINOL LARYN, V108, P227 Bhattacharyya N, 2001, ARCH OTOLARYNGOL, V127, P127 BILLER HF, 1979, ANN OTO RHINOL LARYN, V88, P531 BILLER HF, 1983, ANN OTO RHINOL LARYN, V92, P469 BLITZER A, 1988, LARYNGOSCOPE, V98, P636 Blitzer A, 2010, EUR J NEUROL, V17, P28, DOI 10.1111/j.1468-1331.2010.03047.x BLOCH CS, 1985, ANN OTO RHINOL LARYN, V94, P51 Braden MN, 2010, J VOICE, V24, P242, DOI 10.1016/j.jvoice.2008.08.003 Brin MF, 1992, NEUROLOGIC DISORDERS, P248 BRODNITZ FS, 1976, ANN OTO RHINOL LARYN, V85, P210 Cannito MP, 2004, ARCH OTOLARYNGOL, V130, P1393, DOI 10.1001/archotol.130.12.1393 Chhetri DK, 2006, LARYNGOSCOPE, V116, P635, DOI 10.1097/01.MLG.0000201990.97955.E4 DEDO HH, 1976, ANN OTO RHINOL LARYN, V85, P451 Edgar JD, 2001, J VOICE, V15, P362, DOI 10.1016/S0892-1997(01)00038-8 FRITZELL B, 1982, FOLIA PHONIATR, V34, P160 FRITZELL B, 1993, J VOICE, V7, P172, DOI 10.1016/S0892-1997(05)80348-0 Hogikyan ND, 2001, J VOICE, V15, P576, DOI 10.1016/S0892-1997(01)00060-1 Hogikyan ND, 1999, J VOICE, V13, P557, DOI 10.1016/S0892-1997(99)80010-1 IZDEBSKI K, 1984, AM J OTOLARYNG, V5, P7, DOI 10.1016/S0196-0709(84)80015-0 Kendall KA, 2011, J VOICE, V25, P114, DOI 10.1016/j.jvoice.2009.08.003 Le KD, 2003, NEUROLOGY, V61, P1294 Louis ED, 2000, ARCH NEUROL-CHICAGO, V57, P1194, DOI 10.1001/archneur.57.8.1194 Ludlow CL, 2004, MIT ENCY COMMUNICATI, P38 Ludlow CL, 2009, CURR OPIN OTOLARYNGO, V17, P160, DOI 10.1097/MOO.0b013e32832aef6f Ludlow CL, 2008, OTOLARYNG HEAD NECK, V139, P495, DOI 10.1016/j.otohns.2008.05.624 NETTERVILLE JL, 1991, ANN OTO RHINOL LARYN, V100, P10 Paniello RC, 2008, LARYNGOSCOPE, V118, P564, DOI 10.1097/MLG.0b013e31815e8be0 Roy N, 2005, LARYNGOSCOPE, V115, P311, DOI 10.1097/01.mlg.0000154739.48314.ee Roy N, 2007, LARYNGOSCOPE, V117, P628, DOI 10.1097/MLG.0b013e3180306da1 Roy N, 2004, J SPEECH LANG HEAR R, V47, P281, DOI 10.1044/1092-4388(2004/023) Roy N, 2004, J SPEECH LANG HEAR R, V47, P542, DOI 10.1044/1092-4388(2004/042) Roy N, 2005, LARYNGOSCOPE, V115, P1988, DOI 10.1097/01.mlg.0000179174.32345.41 Roy N, 2007, FOLIA PHONIATR LOGO, V59, P83, DOI 10.1159/000098341 Rubin AD, 2004, ARCH OTOLARYNGOL, V130, P415, DOI 10.1001/archotol.130.4.415 SCHAEFER SD, 1983, LARYNGOSCOPE, V93, P1183 Schwartz SR, 2009, OTOLARYNG HEAD NECK, V141, pS1, DOI 10.1016/j.otohns.2009.06.744 Schweinfurth JM, 2002, LARYNGOSCOPE, V112, P220, DOI 10.1097/00005537-200202000-00004 SERCARZ JA, 1992, OTOLARYNG HEAD NECK, V107, P657 SHIRATZKI H, 1988, ACTA OTO-LARYNGOL, V449, P115 Simonyan K, 2008, BRAIN, V131, P447, DOI 10.1093/brain/awm303 Sulica L, 2010, LARYNGOSCOPE, V120, P516, DOI 10.1002/lary.20702 Weinberger M, 1996, J CLIN EPIDEMIOL, V49, P135, DOI 10.1016/0895-4356(95)00556-0 Wingate JM, 2005, J VOICE, V19, P124, DOI 10.1016/j.jvoice.2004.03.006 WOODSON GE, 1991, J VOICE, V5, P85, DOI 10.1016/S0892-1997(05)80168-7 ZWIRNER P, 1993, J VOICE, V7, P165, DOI 10.1016/S0892-1997(05)80347-9 NR 51 TC 8 Z9 8 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD JUL PY 2011 VL 120 IS 7 BP 465 EP 473 PG 9 WC Otorhinolaryngology SC Otorhinolaryngology GA 795DK UT WOS:000292951500008 PM 21859056 ER PT J AU Jaber, JJ Hawbaker, N Stankiewicz, JA AF Jaber, James J. Hawbaker, Nicolaus Stankiewicz, James A. TI Obstructing Encephaloceles Presenting as Chronic Rhinosinusitis: Lessons Learned From a Case Series SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE chronic rhinosinusitus; encephalocele; sinus surgery AB We present a unique anatomic cause of encephalocele, and describe appropriate diagnosis. Two patients underwent stereotactic image-guided sinus surgery for presumed chronic rhinosinusitis with intraoperative findings of a sinus encephalocele. The first patient underwent a conservative 2-stage management that included an initial cerebrospinal fluid (CSF) leak repair followed by encephalocele resection. The second patient underwent a 1-stage encephalocele resection and CSF leak repair with a septal graft. The sinus surgeon needs to consider the possibility of encephalocele when the ethmoid, sphenoid, or, rarely, frontal sinuses present with an isolated pacification that does not improve with conservative medical therapy. C1 [Jaber, James J.; Hawbaker, Nicolaus; Stankiewicz, James A.] Loyola Univ, Med Ctr, Dept Otolaryngol Head & Neck Surg, Maywood, IL 60153 USA. RP Jaber, JJ (reprint author), Loyola Univ, Med Ctr, Dept Otolaryngol Head & Neck Surg, 2160 S 1st Ave,Maguire Bldg, Maywood, IL 60153 USA. CR Anon JB, 2004, OTOLARYNG HEAD NECK, V130, P794 Benninger MS, 2003, OTOLARYNG HEAD NECK, V129, pS1, DOI 10.1016/S0194-5998(03)01397-4 Huisman TAGM, 2004, EUR RADIOL, V14, P243, DOI 10.1007/s00330-003-2008-3 Kutz JW, 2008, LARYNGOSCOPE, V118, P2195, DOI 10.1097/MLG.0b013e318182f833 Mandl ES, 2007, ACTA NEUROCHIR, V149, P79, DOI 10.1007/s00701-006-1070-4 Purkey MT, 2009, ORL J OTO-RHINO-LARY, V71, P93, DOI 10.1159/000193219 NR 6 TC 0 Z9 0 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD JUL PY 2011 VL 120 IS 7 BP 474 EP 477 PG 4 WC Otorhinolaryngology SC Otorhinolaryngology GA 795DK UT WOS:000292951500009 PM 21859057 ER PT J AU Varghese, AM Cheng, AT AF Varghese, Ajoy M. Cheng, Alan T. TI Epiglottic Repositioning Procedure for Supraglottic Stenosis/Collapse SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article; Proceedings Paper CT Meeting of the Australian-Society-of-Otolaryngology-Head-and-Neck-Surgery CY MAR 28-30, 2010 CL Sydney, AUSTRALIA SP Australian Soc Otolaryngol Head & Neck Surg DE epiglottic cartilage; laryngoscopy; supraglottic stenosis; tracheostomy ID AIRWAY-OBSTRUCTION; LARYNGOMALACIA; PROLAPSE; CHILDREN AB Objectives: Supraglottic stenosis/collapse is an uncommon condition. It can be difficult to detect and may be a cause of failed decannulation following tracheostomy. We present a novel technique to correct supraglottic stenosis/collapse. Methods: We performed a retrospective analysis of the records of patients in whom attempts at decannulation had failed at our center between 2003 and 2007. A subgroup with supraglottic stenosis/collapse with posterior displacement of the base of the epiglottis was identified. Our epiglottic repositioning procedure was performed in these patients. Through an external incision, the epiglottis was divided above the anterior commissure and attached to the superior border of the thyroid cartilage. Results: Eight decannulation failures out of 36 attempted decannulations were identified. Three of these 8 cases involved supraglottic stenosis/collapse due to posterior displacement of the base of the epiglottis. Correction of the supraglottic stenosis/collapse led to successful decannulation in all cases. Conclusions: Diagnosis-directed laryngoscopy is required to identify this condition. We describe precisely a technique of repositioning the epiglottis to correct supraglottic stenosis/collapse. C1 [Varghese, Ajoy M.; Cheng, Alan T.] Sydney Childrens Hosp Network, Dept Pediat Otolaryngol, Sydney, NSW, Australia. RP Varghese, AM (reprint author), POB 610, Strathfield, NSW 2135, Australia. CR Bourolias Constantinos, 2008, Head Face Med, V4, P15, DOI 10.1186/1746-160X-4-15 de Alarcon A, 2008, OTOLARYNG CLIN N AM, V41, P959, DOI 10.1016/j.otc.2008.04.004 Isono S, 2006, PEDIATR ANESTH, V16, P109, DOI 10.1111/j.1460-9595.2005.01769.x KLETZKER GR, 1990, LARYNGOSCOPE, V100, P375 Kuna ST, 1997, AM J RESP CRIT CARE, V155, P1991 Lusk Rodney P., 1997, P381 PERON DL, 1988, LARYNGOSCOPE, V98, P659 Pierce RJ, 1999, CLIN EXP PHARMACOL P, V26, P1, DOI 10.1046/j.1440-1681.1999.02988.x Rutter MJ, 2001, ANN OTO RHINOL LARYN, V110, P210 Siou GS, 2002, J LARYNGOL OTOL, V116, P733 Walner DL, 1997, ARCH OTOLARYNGOL, V123, P337 WOO P, 1992, ANN OTO RHINOL LARYN, V101, P314 NR 12 TC 1 Z9 1 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD JUL PY 2011 VL 120 IS 7 BP 478 EP 483 PG 6 WC Otorhinolaryngology SC Otorhinolaryngology GA 795DK UT WOS:000292951500010 PM 21859058 ER PT J AU Lei, WB Su, ZZ Zhu, XL Xiong, GX Chai, LP Chen, DH Chen, FH Feng, X Liu, KX Wen, WP AF Lei, Wen-bin Su, Zhen-zhong Zhu, Xiao-lin Xiong, Guan-xia Chai, Li-ping Chen, De-hua Chen, Feng-hong Feng, Xia Liu, Ke-xuan Wen, Wei-ping TI Removal of Tracheobronchial Foreign Bodies Via Suspension Laryngoscope and Hopkins Telescope in Infants SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE bronchoscope; endotracheal intubation; general anesthesia; Hopkins telescope; infant; suspension laryngoscope; tracheobronchial foreign body aspiration ID PLAIN CHEST RADIOGRAPHY; DELAYED PRESENTATION; BODY ASPIRATION; MANAGEMENT; CHILDREN; ANESTHESIA; BRONCHOSCOPY; HISTORY; AIRWAY AB Objectives: Tracheobronchial foreign body aspiration is a life-threatening accident in infants, and is still a formidable clinical emergency to both otorhinolaryngologists and anesthesiologists. In this study, we attempted to assess the safety and ease of tracheobronchial foreign body removal in infants via suspension laryngoscopy and Hopkins telescopy under general anesthesia with endotracheal intubation. Methods: The retrospective clinical study from 2006 to 2010 included 50 infants with foreign body aspiration, of whom 35 underwent suspension laryngoscopy and Hopkins telescopy and the other 15 underwent rigid bronchoscopy. All of the procedures were under general anesthesia with endotracheal intubation. Results: All of the patients underwent temporary extubation. The foreign body was successfully removed in 46 cases and was not found in the other 4 cases. The mean operation time in the rigid bronchoscopy group was 13.20 +/- 9.01 minutes, and that in the Hopkins telescopy group was 5.79 +/- 3.54 minutes. The oxygen saturation level was below 90% in 17 cases, of which 7 were in the rigid bronchoscopy group and 10 were in the Hopkins telescopy group. The vital signs, including the partial pressure of carbon dioxide in expiratory gas and the heart rate, were stable in all cases. Conclusions: Foreign body removal in infants via suspension laryngoscopy and Hopkins telescopy under general anesthesia with endotracheal intubation should be promoted, since it is relatively safe and easy for both anesthesiologists and otorhinolaryngologists to perform and has a remarkable success rate. C1 [Lei, Wen-bin; Su, Zhen-zhong; Zhu, Xiao-lin; Xiong, Guan-xia; Chai, Li-ping; Chen, De-hua; Chen, Feng-hong; Wen, Wei-ping] Sun Yat Sen Univ, Otorhinolaryngol Hosp, Affiliated Hosp 1, Otorhinolaryngol Inst,Natl Key Discipline Otorhin, Guangzhou 510080, Guangdong, Peoples R China. [Feng, Xia; Liu, Ke-xuan] Sun Yat Sen Univ, Dept Anesthesiol, Affiliated Hosp 1, Guangzhou 510080, Guangdong, Peoples R China. RP Lei, WB (reprint author), Sun Yat Sen Univ, Otorhinolaryngol Hosp, Affiliated Hosp 1, Otorhinolaryngol Inst,Natl Key Discipline Otorhin, Zhong Shan 2nd Rd 58, Guangzhou 510080, Guangdong, Peoples R China. CR Batra Yatindra K, 2004, Ann Card Anaesth, V7, P137 Digoy GP, 2008, OTOLARYNG CLIN N AM, V41, P485, DOI 10.1016/j.otc.2008.01.013 Divisi D, 2007, THORAC CARDIOV SURG, V55, P249, DOI 10.1055/s-2006-924714 Farrell PT, 2004, PAEDIATR ANAESTH, V14, P84, DOI 10.1046/j.1460-9592.2003.01194.x KIM IG, 1973, LARYNGOSCOPE, V83, P347, DOI 10.1288/00005537-197303000-00004 Kiyan G, 2009, INT J PEDIATR OTORHI, V73, P963, DOI 10.1016/j.ijporl.2009.03.021 Lei WB, 2010, ACTA OTO-LARYNGOL, V130, P281, DOI 10.3109/00016480903051643 Li YZ, 2009, INT J PEDIATR OTORHI, V73, P1624, DOI 10.1016/j.ijporl.2009.08.003 Tokar B, 2004, CLIN RADIOL, V59, P609, DOI 10.1016/j.crad.2004.01.006 Senkaya I, 1997, TURKISH J PEDIATR, V39, P353 Sersar SI, 2006, OTOLARYNG HEAD NECK, V134, P92, DOI 10.1016/j.otohns.2005.08.019 Soodan A, 2004, PEDIATR ANESTH, V14, P947, DOI 10.1111/j.1460-9592.2004.01309.x Swanson KL, 2004, SEM RESP CRIT CARE M, V25, P405, DOI 10.1055/s-2004-832713 Zur KB, 2009, PEDIATR ANESTH, V19, P109, DOI 10.1111/j.1460-9592.2009.03006.x NR 14 TC 1 Z9 1 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD JUL PY 2011 VL 120 IS 7 BP 484 EP 488 PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA 795DK UT WOS:000292951500011 PM 21859059 ER PT J AU Ozmen, S Ozmen, OA Kasapoglu, F AF Ozmen, Suay Ozmen, Omer Afsin Kasapoglu, Fikret TI Effects of Levobupivacaine Versus Bupivacaine Infiltration on Postoperative Analgesia in Pediatric Tonsillectomy Patients: A Randomized, Double-Blind, Placebo-Controlled Study SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE bupivacaine; infiltration; levobupivacaine; pain; tonsillectomy ID PERITONSILLAR INFILTRATION; PAIN RELIEF; CHILDREN; ROPIVACAINE; REDUCTION; PARALYSIS; TONSILS AB Objectives: We compared the effects of levobupivacaine hydrochloride, bupivacaine hydrochloride, and saline injections in alleviating posttonsillectomy pain. Methods: Between November 2009 and April 2010, we recruited 60 patients (36 male and 24 female) between 2 and 12 years of age into the study. After informed consent was obtained from the parents, patients admitted for tonsillectomy were randomized into 3 groups by means of sealed envelopes. Group 1 (20 patients; mean age, 6.45 +/- 2.78 years) received 0.9% sodium chloride (saline solution), group 2 (20 patients; mean age, 5.60 +/- 2.70 years) received 0.25% levobupivacaine hydrochloride, and group 3 (20 patients; mean age, 5.85 +/- 2.43 years) received 0.5% bupivacaine hydrochloride infiltrated around each tonsil. Pain was evaluated with McGrath's face scale. Results: The postoperative pain scores at 1 and 5 hours were similar among the groups (p > 0.05). The pain scores in the levobupivacaine group were lower than those in the saline group at 13 hours (p < 0.017). The pain scores in the bupivacaine and levobupivacaine groups were significantly lower than those in the saline group from 17 to 21 hours until day 6 (p > 0.017). There was no difference between the levobupivacaine and bupivacaine groups (p > 0.017). Conclusions: Local infiltration of levobupivacaine is a relatively safe and effective method and is equivalent to use of bupivacaine for posttonsillectomy pain. C1 [Ozmen, Suay] Dortcelik Childrens Hosp, Otorhinolaryngol Clin, Bursa, Turkey. [Ozmen, Omer Afsin; Kasapoglu, Fikret] Uludag Univ, Fac Med, Dept Otorhinolaryngol, Bursa, Turkey. RP Ozmen, S (reprint author), Sayginkent Sitesi B-42 Nilufer, Bursa, Turkey. CR Akoglu E, 2006, INT J PEDIATR OTORHI, V70, P1169, DOI 10.1016/j.ijporl.2005.12.001 Arikan OK, 2006, J OTOLARYNGOL, V35, P167, DOI 10.2310/7070.2005.0029 BeanLijewski JD, 1997, ANESTH ANALG, V84, P1232, DOI 10.1097/00000539-199706000-00011 Beyer J E, 1990, J Pain Symptom Manage, V5, P350, DOI 10.1016/0885-3924(90)90029-J BROADMAN LM, 1989, LARYNGOSCOPE, V99, P578 Cupero Timothy M, 2003, Ear Nose Throat J, V82, P305 Foster RH, 2000, DRUGS, V59, P551, DOI 10.2165/00003495-200059030-00013 Giannoni C, 2001, ARCH OTOLARYNGOL, V127, P1265 Goldsher M, 1996, ANN OTO RHINOL LARYN, V105, P868 Gunter Joel B, 2002, Paediatr Drugs, V4, P649, DOI 10.2165/00148581-200204100-00003 Hollis LJ, 2000, COCHRANE DB SYST REV JEBELES JA, 1991, PAIN, V47, P305, DOI 10.1016/0304-3959(91)90220-R JEBELES JA, 1993, INT J PEDIATR OTORHI, V25, P149, DOI 10.1016/0165-5876(93)90048-8 Karaaslan K, 2008, INT J PEDIATR OTORHI, V72, P675, DOI 10.1016/j.ijporl.2008.01.029 Kountakis SE, 2002, AM J OTOLARYNG, V23, P76, DOI 10.1053/ajot.2002.28771 Marwick PC, 2009, ANESTH ANALG, V108, P1344, DOI 10.1213/ane.0b013e3181979e17 MCGRATH PA, 1985, ADV PAIN RES THER, V9, P387 Molliex S, 1996, ACTA ANAESTH SCAND, V40, P1210, DOI 10.1111/j.1399-6576.1996.tb05552.x Park AH, 2004, ARCH OTOLARYNGOL, V130, P459, DOI 10.1001/archotol.130.4.459 Perkins J, 2003, ARCH OTOLARYNGOL, V129, P1285, DOI 10.1001/archotol.129.12.1285 Shlizerman L, 2005, AM J OTOLARYNG, V26, P406, DOI 10.1016/j.amjoto.2005.02.019 Somdas MA, 2004, INT J PEDIATR OTORHI, V68, P1391, DOI 10.1016/j.ijporl.2004.05.006 STUART JC, 1994, ANAESTH INTENS CARE, V22, P679 Sun JH, 2010, INT J PEDIATR OTORHI, V74, P369, DOI 10.1016/j.ijporl.2010.01.004 Umuroglu T, 2004, PEDIATR ANESTH, V14, P568, DOI 10.1111/j.1460-9592.2004.01223.x Unal Y, 2007, INT J PEDIATR OTORHI, V71, P83, DOI 10.1016/j.ijporl.2006.09.005 Weksler N, 2001, ACTA ANAESTH SCAND, V45, P1042, DOI 10.1034/j.1399-6576.2001.450820.x NR 27 TC 4 Z9 4 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD JUL PY 2011 VL 120 IS 7 BP 489 EP 493 PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA 795DK UT WOS:000292951500012 PM 21859060 ER PT J AU Agar, NJM Berkowitz, RG AF Agar, Nicholas J. M. Berkowitz, Robert G. TI Airway Complications of Pediatric Extracorporeal Membrane Oxygenation SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article; Proceedings Paper CT Meeting of the American-Broncho-Esophagological-Association CY APR 27-28, 2011 CL Chicago, IL SP Amer Broncho Esophagol Assoc DE acquired subglottic stenosis; ECMO; extracorporeal membrane oxygenation; laryngeal stenosis; laryngotracheal stenosis; tracheostomy ID SUBGLOTTIC STENOSIS; CHILDREN; INTUBATION; SUPPORT AB Objectives: Prolonged intubation is a risk factor for the development of laryngotracheal stenosis. Children who undergo extracorporeal membrane oxygenation (ECMO) usually remain intubated for an extended period. It is unclear whether the impaired cardiorespiratory status that necessitated ECMO places these children at a higher risk of laryngotracheal stenosis. This study was performed to assess the incidences of laryngotracheal stenosis and tracheostomy in children who undergo ECMO. Methods: We identified all patients under 18 years of age who underwent ECMO over a 10-year period concluding July 1, 2009, by use of the extracorporeal life support database of Royal Children's Hospital, Melbourne. All children in this database who underwent either a diagnostic or a therapeutic surgical procedure on the airway were identified. Results: The 218 patients included in the study had an overall survival rate of 51.4%. A total of 14 patients (6.4%) required a surgical procedure on the airway, and 11 of these (5.0%) needed tracheostomy. Ten of these 14 patients (71.4%) survived; of these, 2 presented with congenital laryngotracheal stenosis, 3 developed clinically significant laryngotracheal stenosis as a likely consequence of ECMO, and 5 required tracheostomy alone for long-term ventilation. The rate of airway stenosis was 2.7% in survivors. Conclusions: The rate of laryngotracheal stenosis in children who require ECMO is acceptably low. C1 [Agar, Nicholas J. M.; Berkowitz, Robert G.] Royal Childrens Hosp, Dept Otolaryngol, Melbourne, Vic, Australia. [Berkowitz, Robert G.] Univ Melbourne, Murdoch Childrens Res Inst, Melbourne, Vic, Australia. [Berkowitz, Robert G.] Macquarie Univ, Australian Sch Adv Med, Sydney, NSW 2109, Australia. RP Agar, NJM (reprint author), 17 Chester St, Newtown, Vic 3220, Australia. CR BARTLETT RH, 1976, T AM SOC ART INT ORG, V22, P80 FREEMAN GR, 1972, LARYNGOSCOPE, V82, P1385, DOI 10.1288/00005537-197208000-00001 Gomes Cordeiro AM, 2004, PEDIATR CRIT CARE ME, V5, P364, DOI 10.1097/01.PCC.0000128894.59583.66 Haines NM, 2009, ASAIO J, V55, P111, DOI 10.1097/MAT.0b013e318190b6f7 Mugford M, 2008, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD001340.pub2 Pereira KD, 1997, CHEST, V111, P1769, DOI 10.1378/chest.111.6.1769 Walner DL, 2001, LARYNGOSCOPE, V111, P48, DOI 10.1097/00005537-200101000-00009 Wiel E, 1997, PAEDIATR ANAESTH, V7, P415, DOI 10.1046/j.1460-9592.1997.d01-101.x NR 8 TC 0 Z9 0 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD JUN PY 2011 VL 120 IS 6 BP 353 EP 357 PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA 776YP UT WOS:000291577500001 PM 21774440 ER PT J AU Mueller, CA Pintscher, K Renner, B AF Mueller, Christian Albert Pintscher, Karin Renner, Bertold TI Clinical Test of Gustatory Function Including Umami Taste SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE clinical test; gustation; monosodium glutamate; MSG; taste; umami ID GLUTAMATE; RECEPTOR; HUMANS; SMELL; ACID AB Objectives: Assessment of gustatory function is a central part of the diagnosis of patients with chemosensory dysfunctions. The taste of monosodium glutamate was described as umami taste a century ago by Ikeda. The aim of this study was to extend a validated gustatory test with 4 concentrations of monosodium glutamate. Methods: The investigation included 96 subjects who reported having a normal sense of taste and smell. Taste function was assessed by 4 concentrations of sweet, sour, salty, bitter, and umami tastes (extended version) and compared to results obtained in a control group (n = 139) not presented with umami. In a subgroup of 46 participants, the complete test was repeated within 7 days to obtain retest values. Results: Group comparisons exhibited no differences in taste sensitivity for each of the 4 taste qualities (p > 0.3) and no deviation with regard to the sum of correctly identified tastants (p = 0.81). Test-retest data from the extended version revealed a high correlation of scores (r46 = 0.77; p < 0.001). Conclusions: The results indicate that the extended version of the gustatory test is applicable for experimental and clinical settings. C1 [Mueller, Christian Albert; Pintscher, Karin] Med Univ Vienna, Dept Otorhinolaryngol, A-1090 Vienna, Austria. [Renner, Bertold] Univ Erlangen Nurnberg, Dept Pharmacol, Erlangen, Germany. RP Mueller, CA (reprint author), Med Univ Vienna, Dept Otorhinolaryngol, Waehringer Guertel 18-20, A-1090 Vienna, Austria. CR Bellisle F, 1998, ANN NY ACAD SCI, V855, P438, DOI 10.1111/j.1749-6632.1998.tb10603.x Chaudhari N, 2000, NAT NEUROSCI, V3, P113, DOI 10.1038/72053 DEEMS DA, 1991, ARCH OTOLARYNGOL, V117, P519 GILMORE MM, 1993, CHEM SENSES, V18, P257, DOI 10.1093/chemse/18.3.257 Grushka Miriam, 2003, Pain Res Manag, V8, P133 HENKIN RI, 1963, J CLIN INVEST, V42, P727, DOI 10.1172/JCI104765 Ikeda K, 2002, CHEM SENSES, V27, P847, DOI 10.1093/chemse/27.9.847 Kettenmann B, 2005, CHEM SENSES, V30, pI234, DOI 10.1093/chemse/bjh200 Landis BN, 2005, LARYNGOSCOPE, V115, P1124, DOI 10.1097/01.MLG.0000163750.72441.C3 Lindemann B, 2001, NATURE, V413, P219, DOI 10.1038/35093032 Lugaz O, 2002, CHEM SENSES, V27, P105, DOI 10.1093/chemse/27.2.105 MATTES RD, 1992, AM J CARDIOL, V70, P91, DOI 10.1016/0002-9149(92)91396-L Mueller C, 2003, RHINOLOGY, V41, P2 Mueller CA, 2007, ARCH OTOLARYNGOL, V133, P668, DOI 10.1001/archotol.133.7.668 Mueller CA, 2007, ANN OTO RHINOL LARYN, V116, P498 Naka A, 2010, EUR ARCH OTO-RHINO-L, V267, P547, DOI 10.1007/s00405-009-1123-4 Nelson G, 2002, NATURE, V416, P199, DOI 10.1038/nature726 Roininen K, 1996, PHYSIOL BEHAV, V60, P953, DOI 10.1016/S0031-9384(96)00098-4 SCHIFFMAN SS, 1983, NEW ENGL J MED, V308, P1275 Schiffman SS, 2000, J NUTR, V130, p927S Yamaguchi S, 2000, J NUTR, V130, p921S NR 21 TC 4 Z9 4 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD JUN PY 2011 VL 120 IS 6 BP 358 EP 362 PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA 776YP UT WOS:000291577500002 PM 21774441 ER PT J AU Gristwood, RE Venables, WN AF Gristwood, Ronald Edward Venables, William Norman TI Effects of Fenestra Size and Piston Diameter on the Outcome of Stapes Surgery for Clinical Otosclerosis SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE fenestra size; hearing gain; otosclerosis; piston diameter; stapes surgery ID TOTAL STAPEDECTOMY; STAPEDOTOMY; OPERATION AB Objectives: We determined the effect of piston diameter (0.8 or 0.6 mm) and fenestra size (total, three-quarter, or half removal or calibrated stapedotomy) on hearing gains after stapes surgery for clinical otosclerosis. Methods: We analyzed the mean air conduction hearing gains at various frequencies in a sample of 911 strictly consecutive patients who underwent 1,168 stapes procedures with piston reconstruction carried out by the same surgeon between 1963 and 1979. Assiduous follow-up of patients was attempted for at least 10 years, and in some cases for 20 years. Results over time at the various audiometric frequencies were stored for computer analysis. Results: There is no apparent advantage of one piston diameter (0.8 or 0.6 mm) over another for hearing gains at 0.25, 0.5, 1, 2, 3, and 4 kHz. The slim piston appeared to have a significant advantage for 6 and 8 kHz at 5 to 10 years after operation, but interpretation here requires caution, because the slim piston was usually chosen for cases with a small fenestra. Of the various sizes of footplate fenestras, total removal of the stapes footplate had significantly worse air conduction results, most clearly demonstrated at higher frequencies. Below 2 kHz, there is only weak evidence that the means differ significantly at all for the different sizes of fenestra. Small fenestras (stapedotomies) appear to offer advantages for hearing gains, particularly at the higher frequencies of 3 to 8 kHz, and for at least 10 years. Conclusions: The diameter (0.6 or 0.8 mm) of the pistons selected for reconstruction after stapes surgery appears to have little effect on the outcome, except perhaps at 6 and 8 kHz, where the slim piston appeared to have a significant advantage. The size of the footplate fenestra is Of paramount importance to the outcome. A small footplate fenestra has statistically significant advantages for hearing gain over all other sizes of fenestra (ie, total, three-quarter, or half removal of the footplate), at least for the first 10 years after surgery, at frequencies of 2 kHz and above. Total stapedectomy has given the worst results for hearing gain at frequencies above 2 kHz, and the rate of deterioration of gain over time seems to be more rapid than after small-fenestra techniques. Small fenestras are recommended as the preferred technique in all cases of surgically treatable otosclerosis. C1 [Gristwood, Ronald Edward] Royal Adelaide Hosp, Dept Otolaryngol, Adelaide, SA 5000, Australia. [Venables, William Norman] Univ Adelaide, Dept Stat, Adelaide, SA 5001, Australia. RP Gristwood, RE (reprint author), Toynbee Clin, 12 Walter St, Adelaide, SA 5006, Australia. CR Aarnisalo AA, 2003, OTOL NEUROTOL, V24, P567, DOI 10.1097/00129492-200307000-00006 BAILEY HAT, 1981, LARYNGOSCOPE, V91, P1308 CREMERS CWRJ, 1991, ANN OTO RHINOL LARYN, V100, P959 FISCH U, 1979, HNO, V27, P361 GRISTWOOD RE, 1975, J LARYNGOL OTOL, V89, P1185, DOI 10.1017/S0022215100081573 MCGEE TM, 1981, ANN OTO RHINOL LARYN, V90, P633 Persson P, 1997, ACTA OTO-LARYNGOL, V117, P94, DOI 10.3109/00016489709117998 PLATH P, 1992, HNO, V40, P52 SCHUKNEC.HF, 1969, NEW ENGL J MED, V280, P1154, DOI 10.1056/NEJM196905222802105 Sennaroglu L, 2001, OTOLARYNG HEAD NECK, V124, P279, DOI 10.1067/mhn.2001.112431 Shabana YK, 1999, CLIN OTOLARYNGOL, V24, P91 SHEA JJ, 1962, ARCHIV OTOLARYNGOL, V76, P516 SHEA J J Jr, 1958, Ann Otol Rhinol Laryngol, V67, P932 SMYTH GDL, 1978, ANN OTO RHINOL LARYN, V87, P3 SOMERS T, 1994, ANN OTO RHINOL LARYN, V103, P945 Teig E, 1999, OTO RHINO LARYN NOVA, V9, P252, DOI 10.1159/000027931 NR 16 TC 1 Z9 2 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD JUN PY 2011 VL 120 IS 6 BP 363 EP 371 PG 9 WC Otorhinolaryngology SC Otorhinolaryngology GA 776YP UT WOS:000291577500003 PM 21774442 ER PT J AU Sugimoto, H Ito, M Yoshida, S Hatano, M Yoshizaki, T AF Sugimoto, Hisashi Ito, Makoto Yoshida, Shinya Hatano, Miyako Yoshizaki, Tomokazu TI Concurrent Superselective Intra-arterial Chemotherapy and Radiotherapy for Late-Stage Squamous Cell Carcinoma of the Temporal Bone SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE chemoradiotherapy; intra-arterial chemotherapy; squamous cell carcinoma; temporal bone ID EXTERNAL AUDITORY MEATUS; MIDDLE-EAR; ADVANCED HEAD; CANCER; PROTOCOL AB Objectives: This study evaluated the efficacy of concurrent superselective intra-arterial chemotherapy and radiotherapy without surgery for late-stage squamous cell carcinoma of the temporal bone, which typically has a poor prognosis. Methods: The subjects were 5 patients treated at our hospital between 2007 and 2010 for primary cancer of the temporal bone. One patient had a stage T3 tumor, and 4 patients had T4 tumors, according to the Pittsburgh staging system. All patients received irradiation with a conventional once-daily fraction of 2 Gy, and the total dose ranged from 60 to 66 Gy. Intra-arterial cisplatin via transfemoral catheterization and intravenous sodium thiosulfate were administered. The contribution of each vessel in supplying blood to the primary tumor was determined by real-time computed tomographic angiography. Results: Three patients obtained a complete response. The same 3 patients remain alive without local recurrence (mean survival, 28 months), I patient died of distant metastasis without local recurrence after 19 months, and 1 patient remains alive with local recurrence. Conclusions: Although the small number of patients prevents comparisons with other treatments, the present study obtained good results. This may become an effective treatment for patients with late-stage squamous cell carcinoma of the temporal bone. C1 [Sugimoto, Hisashi; Ito, Makoto; Yoshida, Shinya; Hatano, Miyako; Yoshizaki, Tomokazu] Kanazawa Univ, Grad Sch Med Sci, Dept Otolaryngol Head & Neck Surg, Kanazawa, Ishikawa 9208640, Japan. RP Ito, M (reprint author), Kanazawa Univ, Grad Sch Med Sci, Dept Otolaryngol Head & Neck Surg, 13-1 Takaramachi, Kanazawa, Ishikawa 9208640, Japan. FU Ministry of Education, Science, Sports and Culture of Japan [19591961]; Ministry of Health, Labour and Welfare FX From the Department of Otolaryngology Head and Neck Surgery, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan. This study was supported by Grants-in-Aid for Scientific Research from the Ministry of Education, Science, Sports and Culture of Japan (19591961) and from the Ministry of Health, Labour and Welfare (H21-clinical research-general-007). CR ARRIAGA M, 1990, ANN OTO RHINOL LARYN, V99, P714 Conley J, 1965, Trans Am Otol Soc, V53, P189 GOODWIN WJ, 1980, ARCH OTOLARYNGOL, V106, P675 LEWIS JS, 1983, J LARYNGOL OTOL, V97, P299, DOI 10.1017/S0022215100094172 Moody SA, 2000, AM J OTOL, V21, P582 Nakagawa T, 2006, CANCER SCI, V97, P1070, DOI 10.1111/j.1349-7006.2006.00283.x Nyrop M, 2002, ARCH OTOLARYNGOL, V128, P834 Pemberton LS, 2006, CLIN ONCOL-UK, V18, P390, DOI 10.1016/j.clon.2006.03.001 PRASAD S, 1994, OTOLARYNG HEAD NECK, V110, P270, DOI 10.1016/S0194-5998(94)70769-3 Robbins KT, 1996, ARCH OTOLARYNGOL, V122, P853 ROBBINS KT, 1994, AM J SURG, V168, P419, DOI 10.1016/S0002-9610(05)80089-3 ROBBINS KT, 1992, HEAD NECK-J SCI SPEC, V14, P364, DOI 10.1002/hed.2880140505 PAASKE PB, 1987, CANCER, V59, P156, DOI 10.1002/1097-0142(19870101)59:1<156::AID-CNCR2820590130>3.0.CO;2-# STELL PM, 1984, CLIN OTOLARYNGOL, V9, P281, DOI 10.1111/j.1365-2273.1984.tb01511.x UEDA Y, 2009, J LARYNGOL OTOL S, V31, P75 Yin M, 2006, AURIS NASUS LARYNX, V33, P251, DOI 10.1016/j.anl.2005.11.012 Yoshizaki T, 2009, ANN OTO RHINOL LARYN, V118, P172 NR 17 TC 3 Z9 4 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD JUN PY 2011 VL 120 IS 6 BP 372 EP 376 PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA 776YP UT WOS:000291577500004 PM 21774443 ER PT J AU Nishijima, H Asakage, T Sugasawa, M AF Nishijima, Hironobu Asakage, Takahiro Sugasawa, Masashi TI Malignant Carotid Body Tumor With Systemic Metastases SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE carotid body tumor; histopathology; malignant paraganglioma; metastasis; review ID SPINAL METASTASES; PARAGANGLIOMAS; HEAD; NECK AB Carotid body tumors (CBTs) are rare neoplasms of the carotid body. Most CBTs are benign; however, some can show malignant behavior. Malignant CBTs have an unpredictable history; often, there is no correlation between the histologic findings and the clinical behavior. They are usually diagnosed by the development of local recurrence or lymph node metastasis following total resection of the primary mass, or by the detection of distant metastasis. There are few reports of histopathologic confirmation of malignant CBTs. We report a rare case of malignant CBT with distant metastases, in which the diagnosis was confirmed by histopathology, and present a review of the literature. C1 [Nishijima, Hironobu; Asakage, Takahiro; Sugasawa, Masashi] Univ Tokyo, Fac Med, Dept Otolaryngol, Tokyo 113, Japan. [Sugasawa, Masashi] Saitama Med Univ, Int Med Ctr, Dept Head & Neck Surg, Saitama, Japan. RP Nishijima, H (reprint author), Tokyo Teishin Hosp, Dept Otolaryngol, Chiyoda Ku, 2-14-23 Fujimi, Tokyo 1028798, Japan. CR Carroll W, 2004, HEAD NECK-J SCI SPEC, V26, P301, DOI 10.1002/hed.20017 CROUZET G, 1989, J NEURORADIOLOGY, V16, P172 Hajnzic TF, 1999, MED PEDIATR ONCOL, V32, P399, DOI 10.1002/(SICI)1096-911X(199905)32:5<399::AID-MPO20>3.0.CO;2-V Havekes B, 2007, J CLIN ENDOCR METAB, V92, P1245, DOI 10.1210/jc.2006-1993 Kawai A, 1998, SKELETAL RADIOL, V27, P103 LACK EE, 1979, HUM PATHOL, V10, P191, DOI 10.1016/S0046-8177(79)80008-8 Lee JH, 2002, CANCER, V94, P730, DOI 10.1002/cncr.10252 Mall J, 2000, J CARDIOVASC SURG, V41, P759 MASSEY V, 1992, CANCER, V69, P790, DOI 10.1002/1097-0142(19920201)69:3<790::AID-CNCR2820690329>3.0.CO;2-U MERINO MJ, 1981, CANCER, V47, P1403, DOI 10.1002/1097-0142(19810315)47:6<1403::AID-CNCR2820470627>3.0.CO;2-9 NORTH CA, 1990, CANCER, V66, P2224, DOI 10.1002/1097-0142(19901115)66:10<2224::AID-CNCR2820661031>3.0.CO;2-E Pacheco-Ojeda L, 2001, ANN OTO RHINOL LARYN, V110, P36 Patetsios P, 2002, ANN VASC SURG, V16, P331, DOI 10.1007/s10016-001-0106-8 Rosa M, 2008, DIAGN CYTOPATHOL, V36, P178, DOI 10.1002/dc.20775 WILLIAMS MD, 1992, ARCH SURG-CHICAGO, V127, P963 NR 15 TC 4 Z9 6 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD JUN PY 2011 VL 120 IS 6 BP 381 EP 385 PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA 776YP UT WOS:000291577500006 PM 21774445 ER PT J AU Dun, CAJ Hol, MKS Mylanus, EAM Cremers, CWRJ AF Dun, Catharina A. J. Hol, Myrthe K. S. Mylanus, Emmanuel A. M. Cremers, Cor W. R. J. TI Fitting of an 8.5-Millimeter Abutment for Bone Conduction Devices: Indications and Postintervention Course SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE 8.5-mm abutment; Baha; bone-anchored hearing aid; bone conduction device; implant; longer abutment; revision surgery; skin overgrowth; soft tissue ID ANCHORED HEARING-AID; SIMPLIFIED SURGICAL TECHNIQUE; PERCUTANEOUS IMPLANTS; SKIN REACTIONS; EXPERIENCE AB Objectives: We present indications and clinical outcomes of fitting-an 8.5-mm abutment for bone conduction devices. Methods: In 39 cases with a follow-up time of more than 12 months after fitting of an 8.5-mm abutment, the preintervention and postintervention courses were retrospectively evaluated. The outcome measures were indications for fitting and complications during the preintervention and postintervention courses (local skin reaction, skin level, revision surgery, and implant loss). Results: Soft tissue overgrowth was the most frequent reason (31 of 39 cases) for fitting the 8.5-mm abutment. Severe skin reactions decreased by 7.9% after fitting, and the number of fixtures that remained free of any skin reaction increased by 32.2%. In 7 cases, soft tissue overgrowth required revision surgery before placement of the 8.5-mm abutment; further surgical intervention was needed only once. In 1 case, the 8.5-mm abutment was removed because of recurring soft tissue problems. No spontaneous abutment or implant loss occurred. Conclusions: This retrospective evaluation showed that fitting an 8.5-mm abutment is an easy step in managing soft tissue problems and preventing revision surgery. Also, it is of value in patients with a thick scalp that interferes with bone conduction device coupling. In these cases, we advise placing the 8.5-mm abutment during primary surgery. C1 [Dun, Catharina A. J.; Hol, Myrthe K. S.; Mylanus, Emmanuel A. M.; Cremers, Cor W. R. J.] Radboud Univ Nijmegen, Donders Ctr Cognit Brain & Behav, Dept Otorhinolaryngol, Inst Clin Neurosci,Med Ctr, NL-6500 HB Nijmegen, Netherlands. RP Dun, CAJ (reprint author), Radboud Univ Nijmegen, Donders Ctr Cognit Brain & Behav, Dept Otorhinolaryngol, Inst Clin Neurosci,Med Ctr, POB 9101, NL-6500 HB Nijmegen, Netherlands. RI Mylanus, Emmanuel/D-2255-2010 FU The Cochlear Company FX From the Department of Otorhinolaryngology, Institute of Clinical Neuroscience, Donders Center for Cognition, Brain and Behavior, Radboud University Nijmegen Medical Center, Nijmegen, the Netherlands. The Cochlear Company provided financial support toward this study project. CR de Wolf MJF, 2008, OTOL NEUROTOL, V29, P1100, DOI 10.1097/MAO.0b013e31818599b8 de Wolf MJF, 2008, ANN OTO RHINOL LARYN, V117, P805 de Wolf MJF, 2009, ANN OTO RHINOL LARYN, V118, P525 Doshi J, 2010, OTOL NEUROTOL, V31, P612, DOI 10.1097/MAO.0b013e3181d8d54f Faber HT, 2009, ARCH OTOLARYNGOL, V135, P742, DOI 10.1001/archoto.2009.99 HOLGERS KM, 1988, AM J OTOL, V9, P56 Monksfield P, 2009, OTOL NEUROTOL, V30, P274, DOI 10.1097/MAO.0b013e31819679ca Mylanus E A, 1994, J Invest Surg, V7, P327, DOI 10.3109/08941939409051150 Sheehan PZ, 2006, INT J PEDIATR OTORHI, V70, P981, DOI 10.1016/j.ijporl.2005.10.008 van der Pouw CTM, 1999, ANN OTO RHINOL LARYN, V108, P532 NR 10 TC 3 Z9 3 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD JUN PY 2011 VL 120 IS 6 BP 386 EP 390 PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA 776YP UT WOS:000291577500007 PM 21774446 ER PT J AU Choi, H Park, IH Yoon, HG Lee, HM AF Choi, Hyuk Park, Il-Ho Yoon, Hu Geun Lee, Heung-Man TI Comparison of Nasal Sound Spectral Analysis and Peak Nasal Inspiratory Flow Before and After Decongestion in Patients With Nasal Obstruction SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE allergic rhinitis; decongestion test; nasal obstruction; nasal sound spectral analysis; peak nasal inspiratory flow; visual analog scale ID ALLERGIC RHINITIS; ODIOSOFT-RHINO; SEPTAL DEVIATION; ASTHMA; REPRODUCIBILITY; RHINOMANOMETRY; EPIDEMIOLOGY; BUDESONIDE; FREQUENCY; CHILDREN AB Objectives: We compared the results of nasal sound spectral analysis (NSSA) with the results of peak nasal inspiratory flow (PNIF) testing and use of a visual analog scale in patients with allergic rhinitis with nasal obstruction. Methods: We performed NSSA and PNIF testing on 38 patients with allergic rhinitis and 35 healthy subjects. A diagnostic decongestion test was performed on the patients (not on the control subjects). Twenty minutes after decongestant was sprayed into the nostrils, NSSA and PNIF testing were performed again. Results: There was a significant difference in the PNIF values and the nasal inspiratory sound intensities before and after decongestion (p < 0.001). There was a correlation between the NSSA results at the frequency range of 2 to 4 kHz and the PNIF results. The calculated cutoffs between normal and pathological values were 14.8 dB (2 to 4 kHz) for NSSA and 116 +/- 14.1 L/min for PNIF testing. No significant differences were computed between NSSA and PNIF testing in terms of sensitivity (0.71 versus 0.76) or specificity (0.74 versus 0.80). Conclusions: Use of NSSA and PNIF testing together for assessment of nasal obstruction in allergic rhinitis provides clinical relevance in that it allows a fair degree of reliability. Such testing can be performed as a surrogate for rhinomanometry. C1 [Park, Il-Ho; Lee, Heung-Man] Korea Univ, Coll Med, Dept Otorhinolaryngol Head & Neck Surg, Seoul 152703, South Korea. [Choi, Hyuk; Lee, Heung-Man] Korea Univ, Med Devices Clin Trial Ctr, Gum Hosp, Seoul 152703, South Korea. [Choi, Hyuk] Korea Univ, Dept Biomed Engn, Brain Korea Project Biomed Sci 21, Coll Med, Seoul 152703, South Korea. [Yoon, Hu Geun] Seoul Natl Univ, Coll Med, Dept Biomed Engn, Seoul, South Korea. RP Lee, HM (reprint author), Korea Univ, Coll Med, Dept Otorhinolaryngol Head & Neck Surg, 80 Guro Dong, Seoul 152703, South Korea. FU Ministry for Health, Welfare and Family Affairs [A090084] FX From the Medical Devices Clinical Trial Center, Gum Hospital (Choi, Lee), the Department of Biomedical Engineering, Brain Korea 21 Project for Biomedical Science, College of Medicine (Choi), and the Department of Otorhinolaryngology Head and Neck Surgery, College of Medicine (Park, Lee), Korea University, and the Department of Biomedical Engineering, College of Medicine, Seoul National University (Yoon), Seoul, Korea. This research was supported in part by a grant from the Ministry for Health, Welfare and Family Affairs in 2009 (A090084). CR Bellanti JA, 2000, ALLERGY ASTHMA PROC, V21, P367, DOI 10.2500/108854100778249088 Blaiss MS, 2000, ALLERGY ASTHMA PROC, V21, P7, DOI 10.2500/108854100778248953 Butland BK, 1997, BRIT MED J, V315, P717 Cho SI, 1997, CHEST, V112, P1547, DOI 10.1378/chest.112.6.1547 Cirillo Ignazio, 2003, Eur Ann Allergy Clin Immunol, V35, P204 Fineman SM, 2002, ANN ALLERG ASTHMA IM, V88, P2 Harar RPS, 2001, RHINOLOGY, V39, P211 Lundback B, 1998, CLIN EXP ALLERGY, V28, P3 Oghan F, 2010, EUR ARCH OTO-RHINO-L, V267, P1713, DOI 10.1007/s00405-010-1252-9 Pedersen W, 1998, ALLERGY, V53, P383, DOI 10.1111/j.1398-9995.1998.tb03909.x Phagoo SB, 1997, ALLERGY, V52, P901, DOI 10.1111/j.1398-9995.1997.tb01249.x PRESCOTT CAJ, 1995, INT J PEDIATR OTORHI, V32, P137, DOI 10.1016/0165-5876(94)01125-H Seren E, 2005, AM J RHINOL, V19, P257 Seren E, 2010, AM J RHINOL ALLERGY, V24, pE29, DOI 10.2500/ajra.2010.24.3426 Seren E, 2009, AMJ RHINOL ALLERGY, V23, P316, DOI 10.2500/ajra.2009.23.3323 STRACHAN DP, 1995, CLIN EXP ALLERGY, V25, P791, DOI 10.1111/j.1365-2222.1995.tb00019.x Tahamiler R, 2006, LARYNGOSCOPE, V116, P2050, DOI 10.1097/01.mlg.0000240173.74885.0d Tahamiler R, 2009, ARCH OTOLARYNGOL, V135, P137, DOI 10.1001/archoto.2008.537 Tahamiler R, 2008, J LARYNGOL OTOL, V122, P150, DOI 10.1017/S0022215107009437 Tahamiler R, 2008, ACTA OTO-LARYNGOL, V128, P181, DOI 10.1080/00016480701387140 Tahamiler R, 2008, J OTOLARYNGOL-HEAD N, V37, P285, DOI 10.2310/7070.2008.0060 Tahamiler R, 2007, AM J RHINOL, V21, P711, DOI 10.2500/ajr.2007.21.3106 VIANI L, 1990, J LARYNGOL OTOL, V104, P473, DOI 10.1017/S0022215100112915 WIHL JA, 1988, ANN ALLERGY, V61, P50 NR 24 TC 1 Z9 1 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD JUN PY 2011 VL 120 IS 6 BP 391 EP 396 PG 6 WC Otorhinolaryngology SC Otorhinolaryngology GA 776YP UT WOS:000291577500008 PM 21774447 ER PT J AU Wilson, KF Ward, PD Spector, ME Marentette, LJ AF Wilson, Kevin F. Ward, P. Daniel Spector, Matthew E. Marentette, Lawrence J. TI Orbitocranial Approach for Treatment of Adenoid Cystic Carcinoma of the Lacrimal Gland SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE adenoid cystic carcinoma; lacrimal gland; orbitocranial resection ID MANAGEMENT AB Objectives: Multiple treatment options exist for management of adenoid cystic carcinoma of the lacrimal gland. Our objective was to perform an analysis of outcomes in a cohort of patients with adenoid cystic carcinoma of the lacrimal gland treated identically with an orbitocranial approach. Methods: We performed a retrospective review of 7 consecutive patients who presented to a tertiary care academic medical center between 1995 and 2009 with adenoid cystic carcinoma of the lacrimal gland. Results: All patients were treated with an orbitocranial approach to tumor resection followed by postoperative radiotherapy. The mean and median follow-up times were 39 and 19 months, respectively (range, 7 to 138 months). Six patients had orbital reconstruction using free tissue transfer, and 1 patient had a split-thickness skin graft to line the orbital cavity. Two patients developed distant metastases 18 months and 29 months after surgery and ultimately died with disease. Five patients are alive without disease. Conclusions: The orbitocranial approach followed by postoperative irradiation achieves excellent local and regional control rates for adenoid cystic carcinoma of the lacrimal gland, although patients remain at risk long-term for distant metastases. Orbital bone removal to obtain adequate margins should be a routine part of tumor resection for these malignancies. C1 [Wilson, Kevin F.; Ward, P. Daniel; Spector, Matthew E.; Marentette, Lawrence J.] Univ Michigan, Dept Otolaryngol Head & Neck Surg, Ann Arbor, MI 48109 USA. [Wilson, Kevin F.; Ward, P. Daniel] Univ Utah, Dept Surg, Div Otolaryngol Head & Neck Surg, Salt Lake City, UT USA. RP Wilson, KF (reprint author), 50 N Med Dr 3C120 SOM, Salt Lake City, UT 84132 USA. CR Esmaeli B, 2006, OPHTHAL PLAST RECONS, V22, P366, DOI 10.1097/01.iop.0000232164.00208.b4 Esmaeli B, 2004, OPHTHAL PLAST RECONS, V20, P22, DOI 10.1097/01.IOP.0000105518.72611.4F Font RL, 1998, ARCH OPHTHALMOL-CHIC, V116, P613 MARSH JL, 1981, PLAST RECONSTR SURG, V68, P577, DOI 10.1097/00006534-198110000-00017 NATANEGARA IAAA, 1990, ORBIT, V9, P101, DOI 10.3109/01676839009012354 POLITO E, 1993, ANN OPHTHALMOL, V25, P422 Tse DT, 2006, AM J OPHTHALMOL, V141, P44, DOI 10.1016/j.ajo.2005.08.068 NR 7 TC 0 Z9 1 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD JUN PY 2011 VL 120 IS 6 BP 397 EP 400 PG 4 WC Otorhinolaryngology SC Otorhinolaryngology GA 776YP UT WOS:000291577500009 PM 21774448 ER PT J AU Ohno, S Hirano, S Kanemaru, S Kitani, Y Kojima, T Tateya, I Nakamura, T Ito, J AF Ohno, Satoshi Hirano, Shigeru Kanemaru, Shin-ichi Kitani, Yoshiharu Kojima, Tsuyoshi Tateya, Ichiro Nakamura, Tatsuo Ito, Juichi TI Implantation of an Atelocollagen Sponge With Autologous Bone Marrow-Derived Mesenchymal Stromal Cells for Treatment of Vocal Fold Scarring in a Canine Model SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE atelocollagen; bone marrow-derived mesenchymal stromal cell; extracellular matrix; hyaluronic acid; mesenchymal stem cell; vocal fold scarring ID HEPATOCYTE GROWTH-FACTOR; STEM-CELLS; HISTOLOGIC CHARACTERIZATION; RABBIT MODEL; REGENERATION; FIBROSIS; HGF AB Objectives: Vocal fold scarring remains a therapeutic challenge. A new regenerative approach is needed to restore disorganized extracellular matrix. Tissue regeneration requires appropriate cells and a scaffold. Bone marrow-derived mesenchymal stromal cells (BMSCs) are multipotent and secrete many kinds of growth factors to regenerate tissues. Atelocollagen sponges have many large pores that permit cell entry. The present study was performed to evaluate whether implantation of an atelocollagen sponge plus BMSCs is effective for the treatment of vocal fold scarring. Methods: Twelve beagles underwent implantation of an atelocollagen sponge or of an atelocollagen sponge with autologous BMSCs (1.0 x 10(6) cells) in the subepithelial pockets of scarred vocal folds. Six months after the operation, vibratory examinations and histologic examinations were performed. Results: Mucosal vibrations improved significantly for the atelocollagen sponge-implanted vocal folds. Histologic analyses revealed favorable restoration of the extracellular matrix in the lamina propria. Increased distribution of hyaluronic acid and decreased dense collagen deposition were also noted. These improvements were enhanced by implantation of BMSCs. Conclusions: Implantation of atelocollagen sponges with autologous BMSCs into scarred vocal folds significantly increased hyaluronic acid distribution and decreased dense collagen deposition in the lamina propria, leading to better mucosal vibration. C1 [Ohno, Satoshi] Kyoto Univ, Grad Sch Med, Dept Otolaryngol Head & Neck Surg, Sakyo Ku, Kyoto 6068507, Japan. [Nakamura, Tatsuo] Kyoto Univ, Inst Frontier Med Sci, Dept Bioartificial Organs, Kyoto 6068507, Japan. RP Ohno, S (reprint author), Kyoto Univ, Grad Sch Med, Dept Otolaryngol Head & Neck Surg, Sakyo Ku, Kyoto 6068507, Japan. FU Takeda Science Foundation; Ministry of Health, Labor and Welfare of Japan FX From the Department of Otolaryngology Head and Neck Surgery, Graduate School of Medicine (Ohno, Hirano, Kanemaru, Kitani, Kojima, Tateya, Ito), and the Department of Bioartificial Organs, Institute for Frontier Medical Sciences (Nakamura), Kyoto University, Kyoto, Japan. This study was supported in part by a grant from the Takeda Science Foundation. This article was supported by the Research Projects for Disorders of Sensory Organs from the Ministry of Health, Labor and Welfare of Japan. CR Abramoff M. D., 2004, IMAGE PROCESSING IMA, V11, P36 Belafsky PC, 2004, OTOLARYNG HEAD NECK, V131, P351, DOI 10.1016/j.otohns.2004.03.025 Bessho K, 1998, BRIT J ORAL MAX SURG, V36, P457, DOI 10.1016/S0266-4356(98)90463-6 Gray SD, 1999, LARYNGOSCOPE, V109, P845, DOI 10.1097/00005537-199906000-00001 Gray SD, 2000, ANN OTO RHINOL LARYN, V109, P77 Hachisuka H, 2007, J ORTHOP SCI, V12, P161, DOI 10.1007/s00776-006-1098-6 Hirano S, 2009, J VOICE, V23, P399, DOI 10.1016/j.jvoice.2007.12.002 Hirano S, 2004, ANN OTO RHINOL LARYN, V113, P777 Hirano S, 2003, ANN OTO RHINOL LARYN, V112, P1026 Hirano S, 2003, LARYNGOSCOPE, V113, P966, DOI 10.1097/00005537-200306000-00010 Hirano S, 2004, LARYNGOSCOPE, V114, P548, DOI 10.1097/00005537-200403000-00030 Jiang YH, 2002, NATURE, V418, P41, DOI 10.1038/nature00870 Kanemaru S, 2005, ANN OTO RHINOL LARYN, V114, P907 Kanemaru SI, 2003, ANN OTO RHINOL LARYN, V112, P915 Kishirnoto Y, 2009, ANN OTO RHINOL LARYN, V118, P613 Kishimoto Y, 2010, LARYNGOSCOPE, V120, P108, DOI 10.1002/lary.20642 KOIDE M, 1993, J BIOMED MATER RES, V27, P79, DOI 10.1002/jbm.820270111 Kriesel KJ, 2002, ANN OTO RHINOL LARYN, V111, P884 LANGER R, 1993, SCIENCE, V260, P920, DOI 10.1126/science.8493529 Li LL, 2008, TRANSPL INT, V21, P1181, DOI 10.1111/j.1432-2277.2008.00742.x Matsumoto K, 1997, BIOCHEM BIOPH RES CO, V239, P639, DOI 10.1006/bbrc.1997.7517 Mizuno S, 2005, FASEB J, V19, P580, DOI 10.1096/fj.04-1535fje Neuenschwander MC, 2001, J VOICE, V15, P295, DOI 10.1016/S0892-1997(01)00031-5 Ohno S, 2009, ANN OTO RHINOL LARYN, V118, P805 Ohno T, 2007, ANN OTO RHINOL LARYN, V116, P762 Pasquinelli G, 2007, ULTRASTRUCT PATHOL, V31, P23, DOI 10.1080/01913120601169477 Rousseau B, 2004, ANN OTO RHINOL LARYN, V113, P767 Rousseau B, 2003, LARYNGOSCOPE, V113, P620, DOI 10.1097/00005537-200304000-00007 Rousseau B, 2004, J VOICE, V18, P116, DOI 10.1016/j.jvoice.2003.06.001 Tateya T, 2005, ANN OTO RHINOL LARYN, V114, P183 Thibeault SL, 2002, J VOICE, V16, P96, DOI 10.1016/S0892-1997(02)00078-4 NR 31 TC 10 Z9 12 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD JUN PY 2011 VL 120 IS 6 BP 401 EP 408 PG 8 WC Otorhinolaryngology SC Otorhinolaryngology GA 776YP UT WOS:000291577500010 PM 21774449 ER PT J AU Sira, J Makura, ZGG AF Sira, James Makura, Zvoru G. G. TI Differential Diagnosis of Cystic Neck Lesions SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE branchioma; squamous cell carcinoma; thyroid neoplasm ID BRANCHIAL CYST; NODE METASTASES; CARCINOMA; MANAGEMENT; PITFALLS; HEAD AB Objectives: In patients less than 40 years of age who present with an upper anterior triangle cystic mass, branchial cyst is the presumed clinical diagnosis. Squamous cell malignancy is the important differential diagnosis in a patient more than 40 years of age. We sought to identify the range of lesions that can be clinically mistaken for, and removed as, branchial cysts. Methods: We performed retrospective reviews of 29 neck masses removed as branchial cysts and 47 solitary neck masses diagnosed as cancer between January 2003 and January 2008 across two teaching hospitals in Leeds, England. Results: Of the 29 lesions removed, 23 (79.3%) were confirmed to be branchial cysts. The remainder comprised 2 thyroid papillary carcinomas (6.9%) and 4 benign lesions (13.6%; laryngocele, neurilemmoma, parotid gland cyst, and cystadenoma). Of the 47 cases of metastatic cancer, 3 lesions (6.4%) were clinically mistaken as branchial cysts but were subsequently diagnosed as squamous cell carcinomas. Conclusions: When presented with a solitary lateral cystic mass, clinicians should consider the possibility of squamous cell carcinoma in patients more than 40 years of age, and thyroid papillary cancer should be considered particularly in the younger age groups. In our series, 30.8% of the neck lesions believed to be branchial cysts in patients over 40 were malignant, in contrast to 5.3% of those lesions in patients under 40. C1 [Sira, James; Makura, Zvoru G. G.] Leeds Gen Infirm, Dept Otolaryngol Head & Neck Surg, Leeds, W Yorkshire, England. RP Sira, J (reprint author), Flat 1 St Anns Tower,214 Kirkstall Lane, Leeds LS6 3DS, W Yorkshire, England. CR Al-Khateeb TH, 2007, J ORAL MAXIL SURG, V65, P2242, DOI 10.1016/j.jams.2006.11.039 Andrews PJ, 2003, J LARYNGOL OTOL, V117, P318 Daoud Faiez S, 2005, Asian J Surg, V28, P174, DOI 10.1016/S1015-9584(09)60337-7 Doshi J, 2007, ANN OTO RHINOL LARYN, V116, P112 FLANAGAN PM, 1994, J LARYNGOL OTOL, V108, P1068 Goldenberg D, 2006, HEAD NECK-J SCI SPEC, V28, P633, DOI 10.1002/hed.20381 Hart C, 2006, OTOLARYNG HEAD NECK, V135, P955, DOI 10.1016/j.otohns.2005.04.026 Kadhim AL, 2004, J LARYNGOL OTOL, V118, P946 Mallet Y, 2005, ORAL ONCOL, V41, P429, DOI 10.1016/j.oraloncology.2004.09.016 McClure MJ, 1998, ULSTER MED J, V67, P129 Mehmood Rao K, 2006, Ear Nose Throat J, V85, P675 Nakagawa T, 2001, J LARYNGOL OTOL, V115, P240 Seven H, 2004, AM J OTOLARYNG, V25, P11, DOI 10.1016/j.amjoto.2003.10.002 Sheahan P, 2002, OTOLARYNG HEAD NECK, V127, P294, DOI 10.1067/mhn.2002.128600 Thompson Lester D R, 2004, Ear Nose Throat J, V83, P740 NR 15 TC 3 Z9 4 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD JUN PY 2011 VL 120 IS 6 BP 409 EP 413 PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA 776YP UT WOS:000291577500011 PM 21774450 ER PT J AU Pauw, RJ Huygen, PLM Colditz, GM Cremers, CWRJ AF Pauw, Robert J. Huygen, Patrick L. M. Colditz, Gordon M. Cremers, Cor W. R. J. TI Phenotype Analysis of an Australian DFNA9 Family With the I109N COCH Mutation SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE DFNA9; genotype; nonsyndromic hearing impairment; phenotype; sensorineural hearing impairment ID SENSORINEURAL HEARING-LOSS; TEMPORAL BONE FINDINGS; COCHLEOVESTIBULAR DYSFUNCTION; VESTIBULAR DYSFUNCTION; MENIERES-DISEASE; VWFA2 DOMAIN; GENE; IMPAIRMENT; DEAFNESS; G87W AB Objectives: We studied the clinical characteristics of an Australian family with an autosomal dominant sensorineural hearing impairment (DFNA9) caused by an I109N mutation in COCH. Methods: Retrospective analyses of audiometric data from 8 mutation carriers of an Australian DFNA9 family with the I109N COCH mutation were performed. Cross-sectional hearing levels related to age, age-related typical audiograms, and speech recognition scores related to age and to the level of hearing impairment were investigated. Data were compared to those obtained in previously identified DFNA9 families with P51S, V66G, G87W, G88E, I109T, and C542F COCH mutations. Results: Deterioration of hearing in the I109N mutation carriers started before the age of 40 years. The audiometric characteristics of the 1109N mutation carriers are essentially similar to those previously established in I109T mutation carriers and, to a lesser extent, in P51S, G87W, and G88E mutation carriers. Conclusions: The phenotype associated with the 1109N COCH mutation is largely similar to that associated with the I109T. P51S. G87W, and G88E mutation carriers. However, subtle differences seem to exist in terms of age of onset and rate of progression. C1 [Pauw, Robert J.; Huygen, Patrick L. M.; Cremers, Cor W. R. J.] Radboud Univ Nijmegen, Med Ctr, Dept Otorhinolaryngol, NL-6500 HB Nijmegen, Netherlands. [Colditz, Gordon M.] Univ Sydney, Dept Med, Sydney, NSW 2006, Australia. RP Pauw, RJ (reprint author), Radboud Univ Nijmegen, Med Ctr, Dept Otorhinolaryngol, 383,POB 9101, NL-6500 HB Nijmegen, Netherlands. RI Colditz, Graham/A-3963-2009 OI Colditz, Graham/0000-0002-7307-0291 FU European Commission [LSHG-CT-2004-512063] FX From the Department of Otorhinolaryngology, Radboud University Nijmegen Medical Center, Nijmegen, the Netherlands (Pauw, Huygen. Cremers), and the Department of Medicine, University of Sydney, Sydney, Australia (Colditz). This work was supported by the European Commission FP6 Integrated Project EUROHEAR, LSHG-CT-2004-512063. CR Bischoff AMLC, 2005, OTOL NEUROTOL, V26, P918, DOI 10.1097/01.mao.0000185048.84641.e3 Bom SJH, 1999, LARYNGOSCOPE, V109, P1525, DOI 10.1097/00005537-199909000-00031 Bom SJH, 2003, ANN OTO RHINOL LARYN, V112, P280 Bom SJH, 2001, ARCH OTOLARYNGOL, V127, P1045 Collin RWJ, 2006, AM J MED GENET A, V140A, P1791, DOI 10.1002/ajmg.a.31354 de Kok YJM, 1999, HUM MOL GENET, V8, P361, DOI 10.1093/hmg/8.2.361 Fransen E, 1999, HUM MOL GENET, V8, P1425, DOI 10.1093/hmg/8.8.1425 Hildebrand MS, 2009, AM J MED GENET A, V149A, P280, DOI 10.1002/ajmg.a.32618 Huygen PL, 2003, AUDIOL MED, V1, P37 International Organization for Standardization, 1984, 7029 ISO Kamarinos M, 2001, Hum Mutat, V17, P351, DOI 10.1002/humu.37 Kemperman MH, 2005, OTOL NEUROTOL, V26, P926, DOI 10.1097/01.mao.0000185062.12458.87 KHETARPAL U, 1991, ARCH OTOLARYNGOL, V117, P1032 KHETARPAL U, 1993, ARCH OTOLARYNGOL, V119, P106 Lemaire FX, 2003, OTOL NEUROTOL, V24, P743, DOI 10.1097/00129492-200309000-00009 Manolis EN, 1996, HUM MOL GENET, V5, P1047, DOI 10.1093/hmg/5.7.1047 Nagy I, 2004, J MED GENET, V41, DOI 10.1136/jmg.2003.012286 Pauw RJ, 2007, AUDIOL NEURO-OTOL, V12, P77, DOI 10.1159/000097794 Pauw RJ, 2007, ANN OTO RHINOL LARYN, V116, P349 Robertson NG, 2006, HUM MOL GENET, V15, P1071, DOI 10.1093/hmg/ddl022 Robertson NG, 1998, NAT GENET, V20, P299 Street VA, 2005, AM J MED GENET A, V139A, P86, DOI 10.1002/ajmg.a.30980 Usami S, 2003, EUR J HUM GENET, V11, P744, DOI 10.1038/sj.ejhg.5201043 VERHAGEN WIM, 1988, ARCH NEUROL-CHICAGO, V45, P766 Verhagen WIM, 2001, CLIN OTOLARYNGOL, V26, P477, DOI 10.1046/j.1365-2273.2001.00505.x Yao JH, 2010, J BIOL CHEM, V285, P14909, DOI 10.1074/jbc.M110.106724 Yuan HJ, 2008, CLIN GENET, V73, P391, DOI 10.1111/j.1399-0004.2008.00972.x NR 27 TC 1 Z9 1 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD JUN PY 2011 VL 120 IS 6 BP 414 EP 421 PG 8 WC Otorhinolaryngology SC Otorhinolaryngology GA 776YP UT WOS:000291577500012 PM 21774451 ER PT J AU Visvanathan, A Rinaldi, V Visvanathan, PG AF Visvanathan, Anjana Rinaldi, Vittorio Visvanathan, Pumalur G. TI Fallopian Canal Stapedotomy in Congenital Stapes Fixation With Aberrant Facial Nerve SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE aberrant facial nerve; congenital stapes fixation; ossicular chain malformation ID STAPEDECTOMY; CHILDREN; ANKYLOSIS; EARS AB Congenital stapes ankylosis is reported to have an occurrence rate of 3% to 4%, and it represents 20% to 35% of ossicular malformations. Surgical treatment of congenital stapes ankylosis is described to be satisfactory in the large majority of the case series reported in the literature. In these cases, special attention should be paid to exclude any aberrations of the course of the facial nerve, which have been demonstrated to be frequently associated with congenital middle ear malformations. We describe a case of congenital stapes ankylosis associated with a previously unreported facial nerve abnormality, characterized by the presence of an empty fallopian canal in combination with a dehiscent facial nerve running over the footplate and almost totally covering it. C1 [Visvanathan, Anjana; Rinaldi, Vittorio; Visvanathan, Pumalur G.] Vikram ENT Hosp & Res Inst, Coimbatore 641002, Tamil Nadu, India. RP Rinaldi, V (reprint author), Vikram ENT Hosp & Res Inst, 69 W Venkataswamy Rd, Coimbatore 641002, Tamil Nadu, India. CR Albert S, 2006, LARYNGOSCOPE, V116, P1153, DOI 10.1097/01.mlg.0000227501.78004.f6 Ballester M, 2000, Rev Laryngol Otol Rhinol (Bord), V121, P181 Boone R, 2002, OTOLARYNG HEAD NECK, V127, P342, DOI 10.1067/mhn.2002.128602 De la Cruz A, 1999, OTOLARYNG HEAD NECK, V120, P487, DOI 10.1053/hn.1999.v120.a89626 HOUSE JW, 1980, LARYNGOSCOPE, V90, P1804, DOI 10.1288/00005537-198011000-00007 Huang TS, 1997, OTOLARYNG HEAD NECK, V116, P438, DOI 10.1016/S0194-5998(97)70291-2 Kisilevsky VE, 2009, INT J PEDIATR OTORHI, V73, P1712, DOI 10.1016/j.ijporl.2009.09.005 KUHN JJ, OTOL NEUROT IN PRESS Martin C, 2006, EUR ARCH OTO-RHINO-L, V263, P79, DOI 10.1007/s00405-005-0951-0 Massey BL, 2006, OTOLARYNG HEAD NECK, V134, P816, DOI 10.1016/j.otohns.2005.10.063 Millman B, 1996, OTOLARYNG HEAD NECK, V115, P78, DOI 10.1016/S0194-5998(96)70140-7 TEUNISSEN B, 1990, LARYNGOSCOPE, V100, P1331 TEUNISSEN EB, 1993, ANN OTO RHINOL LARYN, V102, P606 NR 13 TC 1 Z9 1 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD JUN PY 2011 VL 120 IS 6 BP 377 EP 380 PG 4 WC Otorhinolaryngology SC Otorhinolaryngology GA 776YP UT WOS:000291577500005 PM 21774444 ER PT J AU Koufman, JA AF Koufman, Jamie A. TI Low-Acid Diet for Recalcitrant Laryngopharyngeal Reflux: Therapeutic Benefits and Their Implications SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article; Proceedings Paper CT Annual Meeting of the American-Broncho-Esophagological-Association CY APR 28-29, 2010 CL Las Vegas, NV SP Amer Broncho Esophagol Assoc DE acid reflux; adenocarcinoma; antireflux; Barrett's esophagus; chronic cough; diet; esophageal cancer; gastroesophageal reflux disease; heartburn; hoarseness; laryngopharyngeal reflux; low acid; low fat; pepsin; proton pump inhibitor ID LARYNGEAL EPITHELIAL DEFENSES; ANHYDRASE ISOENZYME-III; GASTROESOPHAGEAL-REFLUX; ESOPHAGEAL ADENOCARCINOMA; POSITION STATEMENT; CELL BIOLOGY; DISEASE; PEPSIN; SYMPTOMS; RELIABILITY AB Objectives: Laryngopharyngeal reflux (LPR) is an expensive, high-prevalence disease with a high rate of medical treatment failure. In the past, it was mistakenly believed that pepsin was inactive above pH 4; however, human pepsin has been reported to be active up to pH 6.5. In addition, it has been shown by Western blot analysis that laryngeal biopsy samples from patients with symptomatic LPR have tissue-bound pepsin. The clinical impact of a low-acid diet on the therapeutic outcome in LPR has not been previously reported. To provide data on the therapeutic benefit of a strict, virtually acid-free diet on patients with recalcitrant, proton pump inhibitor (PPI) resistant LPR, I performed a prospective study of 20 patients who had persistent LPR symptoms despite use of twice-daily PPIs and an H2-receptor antagonist at bedtime. Methods: The reflux symptom index (RSI) score and the reflux finding score (RFS) were determined before and after implementation of the low-acid diet, in which all foods and beverages at less than pH 5 were eliminated for a minimum 2-week period. The subjects were individually counseled, and a printed list of acceptable foods and beverages was provided. Results: There were 12 male and 8 female study subjects with a mean age of 54.3 years (range, 24 to 72 years). The symptoms in 19 of the 20 subjects (95%) improved, and 3 subjects became completely asymptomatic. The mean pre-diet RSI score was 14.9, and the mean post-diet RSI score was 8.6 (p = 0.020). The mean pre-diet RFS was 12.0, and the mean post-diet RFS was 8.3 (p < 0.001). Conclusions: A strict low-acid diet appears to have beneficial effects on the symptoms and findings of recalcitrant (PPI-resistant) LPR. Further study is needed to assess the optimal duration of dietary acid restriction and to assess the potential role of a low-acid diet as a primary treatment for LPR. This study has implications for understanding the pathogenesis, cell biology, and epidemiology of reflux disease. C1 Voice Inst New York, New York, NY 10019 USA. RP Koufman, JA (reprint author), Voice Inst New York, 200 W 57th St,Suite 1203, New York, NY 10019 USA. CR Altman KW, 2005, LARYNGOSCOPE, V115, P1145, DOI 10.1097/01.MLG.0000165464.75164.ES *AM BEV ASS CTR RE, LOBB 2009 Amin MR, 2008, OTOLARYNG HEAD NECK, V138, P411, DOI 10.1016/j.otohns.2007.12.032 Amin MR, 2009, OTOLARYNG HEAD NECK, V140, P280 Amin MR, 2001, OTOLARYNG HEAD NECK, V125, P374, DOI 10.1067/mhn.2001.118691 [Anonymous], 2009, GEN REC SAF FOOD ADD Axford SE, 2001, ANN OTO RHINOL LARYN, V110, P1099 Belafsky PC, 2002, J VOICE, V16, P274, DOI 10.1016/S0892-1997(02)00097-8 Belafsky PC, 2001, LARYNGOSCOPE, V111, P1313, DOI 10.1097/00005537-200108000-00001 Belafsky PC, 2001, LARYNGOSCOPE, V111, P979, DOI 10.1097/00005537-200106000-00009 BELLIS M, INTRO POP HIST SOFT Conio M, 2003, AM J GASTROENTEROL, V98, P1931, DOI 10.1016/S0002-9270(03)00629-4 El-Serag H, 2010, ALIMENT PHARM THER, V32, P720, DOI 10.1111/j.1365-2036.2010.04406.x El-Serag HB, 2007, CLIN GASTROENTEROL H, V5, P17, DOI 10.1016/j.cgh.2006.09.016 Gill GA, 2005, ANN OTO RHINOL LARYN, V114, P913 Halum SL, 2005, LARYNGOSCOPE, V115, P1042, DOI 10.1097/01.MLG.0000162656.05715.57 JOHNSON LF, 1986, J CLIN GASTROENTEROL, V8, P26, DOI 10.1097/00004836-198606001-00006 Johnston N, 2007, LARYNGOSCOPE, V117, P1036, DOI 10.1097/M1LG.0b013e31804154c3 Johnston N, 2006, ANN OTO RHINOL LARYN, V115, P47 Johnston N, 2004, LARYNGOSCOPE, V114, P2129, DOI 10.1097/01.mlg.0000149445.07146.03 Johnston N, 2003, ANN OTO RHINOL LARYN, V112, P481 Knight J, 2005, LARYNGOSCOPE, V115, P1473, DOI 10.1097/01.mlg.0000172043.51871.d9 Koufman J, 2010, DROPPING ACID REFLUX KOUFMAN JA, 1991, LARYNGOSCOPE, V101, P1 Koufman JA, 2002, LARYNGOSCOPE, V112, P1606, DOI 10.1097/00005537-200209000-00014 Koufman JA, 1988, J VOICE, V2, P78, DOI 10.1016/S0892-1997(88)80060-2 Koufman JA, 2009, CLASSICS VOICE LARYN, P179 Koufman JA, 2002, OTOLARYNG HEAD NECK, V127, P32, DOI 10.1067/mhn.2002.125760 LILLEMOE KD, 1982, SURGERY, V92, P276 LUND O, 1989, BRIT J SURG, V76, P1301, DOI 10.1002/bjs.1800761227 Pohl H, 2005, J NATL CANCER I, V97, P142, DOI 10.1093/jnci/dji024 Postma GN, 2001, ANN OTO RHINOL LARYN, V110, P1114 Reavis KM, 2004, ANN SURG, V239, P849, DOI 10.1097/01.sla.0000128303.05898.ee Samuels TL, 2010, ANN OTO RHINOL LARYN, V119, P203 *US GOV ACC OFF, 2010, GAO10246 Westman JA, 2010, CANCER CAUSE CONTROL, V21, P69, DOI 10.1007/s10552-009-9435-7 NR 36 TC 9 Z9 10 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD MAY PY 2011 VL 120 IS 5 BP 281 EP 287 PG 7 WC Otorhinolaryngology SC Otorhinolaryngology GA 767FM UT WOS:000290840700001 PM 21675582 ER PT J AU Butler, SG Stuart, A Case, LD Rees, C Vitolins, M Kritchevsky, SB AF Butler, Susan G. Stuart, Andrew Case, L. Douglas Rees, Catherine Vitolins, Mara Kritchevsky, Stephen B. TI Effects of Liquid Type, Delivery Method, and Bolus Volume on Penetration-Aspiration Scores in Healthy Older Adults During Flexible Endoscopic Evaluation of Swallowing SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE bolus volume; delivery method; endoscopy; FEES; flexible endoscopic evaluation of swallowing; liquid; swallowing ID AGE-RELATED-CHANGES; TASTE; PHYSIOLOGY; DYSPHAGIA; YOUNG; REPLICATION; PHARYNGEAL; VISCOSITY; SENSATION; MECHANISM AB Objectives: The type of liquid (eg, water or milk) that should be used during flexible endoscopic evaluation of swallowing (FEES) has received little investigation. Aspiration may vary as a function of the thin liquid type used during FEES. Methods: We measured the effects of liquid type (water, skim milk, 2% milk, and whole milk; all dyed with green food coloring), delivery method (cup and straw), and bolus volume (5, 10, 15, and 20 mL) on Penetration-Aspiration Scale (PAS) scores in 14 healthy older adults (mean, 75 years; range, 69 to 85 years). Each participant generated 32 swallows. Results: The PAS scores differed significantly by liquid type (p = 0.003) and by bolus volume (p = 0.017), but not by delivery method (p = 0.442). The PAS scores were significantly greater for 2% milk and whole milk than for skim milk and water (p < 0.05), and for 20 mL versus smaller volumes. Penetration and aspiration were observed on 113 (25%) and 15 (3%) of 448 swallows, respectively. Conclusions: These findings suggest that both milk and water should be used during FEES for an accurate assessment of aspiration status. C1 [Butler, Susan G.; Rees, Catherine] Wake Forest Univ, Sch Med, Dept Otolaryngol, Winston Salem, NC 27157 USA. [Case, L. Douglas] Wake Forest Univ, Sch Med, Dept Biostat Sci, Winston Salem, NC 27157 USA. [Vitolins, Mara] Wake Forest Univ, Sch Med, Dept Epidemiol & Prevent, Winston Salem, NC 27157 USA. [Kritchevsky, Stephen B.] Wake Forest Univ, Sch Med, Dept Internal Med, Winston Salem, NC 27157 USA. [Stuart, Andrew] E Carolina Univ, Dept Commun Sci, Greenville, NC USA. RP Butler, SG (reprint author), Wake Forest Univ, Sch Med, Dept Otolaryngol, Med Ctr Blvd, Winston Salem, NC 27157 USA. CR Adnerhill I, 1989, Dysphagia, V4, P1, DOI 10.1007/BF02407395 MARTIN JH, 1994, ANN OTO RHINOL LARYN, V103, P749 Bulow M, 2003, ACTA RADIOL, V44, P366, DOI 10.1034/j.1600-0455.2003.00100.x Butler SG, 2004, OTOLARYNG HEAD NECK, V131, P860, DOI 10.1016/j.otohns.2004.06.706 Butler SG, 2010, LARYNGOSCOPE, V120, P2147, DOI 10.1002/lary.21116 Butler SG, 2009, ANN OTO RHINOL LARYN, V118, P190 Butler SG, 2009, ANN OTO RHINOL LARYN, V118, P99 CALHOUN KH, 1992, LARYNGOSCOPE, V102, P109 Colodny N, 2002, DYSPHAGIA, V17, P308, DOI 10.1007/s00455-002-0073-0 Daggett A, 2006, DYSPHAGIA, V21, P270, DOI 10.1007/s00455-006-9051-6 Daniels SK, 2007, AM J SPEECH-LANG PAT, V16, P140, DOI 10.1044/1058-0360(2007/018) Daniels SK, 2004, J SPEECH LANG HEAR R, V47, P33, DOI 10.1044/1092-4388(2004/004) Pelletier CA, 2006, DYSPHAGIA, V21, P121, DOI 10.1007/s00455-006-9020-0 Ding RY, 2003, J SPEECH LANG HEAR R, V46, P977, DOI 10.1044/1092-4388(2003/076) Fleiss J, 2003, STAT METHODS RATES P, V3rd Hiss SG, 2004, J SPEECH LANG HEAR R, V47, P572, DOI 10.1044/1092-4388(2004/044) Huggins PS, 1999, DYSPHAGIA, V14, P157, DOI 10.1007/PL00009598 Kelly AM, 2007, LARYNGOSCOPE, V117, P1723, DOI 10.1097/MLG.0b013e318123ee6a LANDIS JR, 1977, BIOMETRICS, V33, P159, DOI 10.2307/2529310 LANGMORE SE, 1991, ANN OTO RHINOL LARYN, V100, P678 Leder SB, 1998, DYSPHAGIA, V13, P19, DOI 10.1007/PL00009544 LOGEMANN JA, 1995, J SPEECH HEAR RES, V38, P556 MUMA JR, 1993, J SPEECH HEAR RES, V36, P927 Ng K, 2004, J PAIN SYMPTOM MANAG, V28, P28, DOI 10.1016/j.jpainsymman.2003.11.007 Pelletier CA, 2003, DYSPHAGIA, V18, P231, DOI 10.1007/s00455-003-0013-y Rao N, 2003, J APPL RES, V3, P89 Rosenbek JC, 1996, DYSPHAGIA, V11, P93, DOI 10.1007/BF00417897 Suiter DM, 2007, OTOLARYNG HEAD NECK, V137, P956, DOI 10.1016/j.otohns.2007.09.004 WARDWELL L, 2009, INT J FOOD SCI NUTR, V60, P1 NR 29 TC 8 Z9 8 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD MAY PY 2011 VL 120 IS 5 BP 288 EP 295 PG 8 WC Otorhinolaryngology SC Otorhinolaryngology GA 767FM UT WOS:000290840700002 PM 21675583 ER PT J AU Riffat, F Jefferson, N Bari, N McGuinness, J AF Riffat, Faruque Jefferson, Niall Bari, Noor McGuinness, John TI Acute Supraglottitis in Adults SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article; Proceedings Paper CT Annual Meeting of the American-Academy-of-Otolaryngology-Head-and-Neck-Surgery CY SEP 26-29, 2010 CL Boston, MA SP Amer Acad Otolaryngol Head & Neck Surg Fdn DE epiglottitis; intubation; steroids; supraglottitis; tracheotomy ID ACUTE EPIGLOTTITIS; VACCINATION; EXPERIENCE; PATTERNS; DISEASE AB Objectives: Adult supraglottitis is a potentially life-threatening airway infection. We reviewed the management and outcome of supraglottitis in 169 adults admitted to Liverpool Hospital between 1999 and 2009. Methods: A retrospective review was conducted of all admissions with supraglottitis in patients at least 18 years of age. The diagnosis was confirmed by fiberoptic nasolaryngoscopy or direct laryngoscopy under general anesthesia. The main outcome measure was the need for intubation or tracheotomy. Univariate analysis was performed to determine factors that led to a worse outcome. Results: There were 80 men and 89 women in the cohort, with a median age of 51 years. Of these, 140 patients were admitted to the intensive care unit for a mean duration of 2 days. The common symptoms and signs at presentation were odynophagia and dysphagia (94%), dysphonia (65%), and stridor (33%). Endotracheal intubation was performed in 16 patients, and an awake tracheotomy was required in 4 patients. Dexamethasone acetate was used in 103 patients. Thirty-five patients had diabetes mellitus as a comorbidity. The presence of diabetes was predictive of the need for intubation or tracheotomy (p<0.05), and the use of steroids was predictive of an intensive care unit stay of 24 hours or less (p<0.05). Conclusions: Fiberoptic laryngoscopy is the gold standard for diagnosis of supraglottitis, and close airway monitoring is crucial. Conservative management of the airway is a viable option, but the presence of diabetes makes airway intervention more likely. The use of steroids aids in symptom alleviation and hastens resolution of airway swelling, with no negative sequelae. C1 [Riffat, Faruque; Jefferson, Niall; McGuinness, John] Liverpool Hosp, Dept Otolaryngol Head & Neck Surg, Sydney, NSW 2170, Australia. [Bari, Noor] Liverpool Hosp, Dept Emergency Med, Sydney, NSW 2170, Australia. RP Riffat, F (reprint author), Liverpool Hosp, Dept Otolaryngol Head & Neck Surg, Elizabeth Dr, Sydney, NSW 2170, Australia. CR Ames WA, 2000, BRIT J ANAESTH, V85, P795, DOI 10.1093/bja/85.5.795 Cetinkaya F, 2004, INT J PEDIATR OTORHI, V68, P453, DOI 10.1016/j.ijporl.2003.11.017 Cha SI, 2007, BURNS, V33, P200, DOI 10.1016/j.burns.2006.07017 CROSBY E, 1991, CAN J ANAESTH, V38, P914 Ducic Y, 1997, ANN EMERG MED, V30, P1, DOI 10.1016/S0196-0644(97)70102-1 FRANTZ TD, 1994, JAMA-J AM MED ASSOC, V272, P1358, DOI 10.1001/jama.272.17.1358 FRANTZ TD, 1993, OTOLARYNG HEAD NECK, V109, P457 FRIEDMAN M, 1988, Ear Nose and Throat Journal, V67, P873 Glynn F, 2007, J Laryngol Otol, V121, pe16, DOI 10.1017/S0022215107000217 Hargreaves RM, 1996, BRIT MED J, V312, P160 Katori H, 2005, J LARYNGOL OTOL, V119, P967 Lin HT, 2006, J LARYNGOL OTOL, V120, P650, DOI 10.1017/S0022215106001149 MAYOSMITH MF, 1995, CHEST, V108, P1640, DOI 10.1378/chest.108.6.1640 Ng HL, 2008, EMERG MED J, V25, P253, DOI 10.1136/emj.2007.050153 Wong EYH, 2001, ANZ J SURG, V71, P740, DOI 10.1046/j.1445-1433.2001.02265.x Wood N, 2005, INTERN MED J, V35, P530, DOI 10.1111/j.1445-5994.2005.00909.x NR 16 TC 2 Z9 2 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD MAY PY 2011 VL 120 IS 5 BP 296 EP 299 PG 4 WC Otorhinolaryngology SC Otorhinolaryngology GA 767FM UT WOS:000290840700003 PM 21675584 ER PT J AU Saito, T Narita, N Yamada, T Manabe, Y Ito, T AF Saito, Takehisa Narita, Norihiko Yamada, Takechiyo Manabe, Yasuhiro Ito, Tetsufumi TI Morphology of Human Fungiform Papillae After Severing Chorda Tympani Nerve SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE chorda tympani nerve; electrogustometry; fungiform papillae; regeneration ID MIDDLE-EAR SURGERY; TASTE FUNCTION; ELECTROGUSTOMETRY AB Objectives: We aimed to clarify the postoperative morphology of the fungiform papillae (FP) of the tongue in patients who recovered gustatory function after the chorda tympani nerve was severed during middle ear surgery. Methods: Fifty-four patients with normal preoperative gustatory function measured by electrogustometry (EGM) were included. The proximal and distal stumps of the severed nerves were re-adapted or re-approximated during surgery to promote regeneration of the nerve. The EGM thresholds over 2 years after surgery were compared with preoperative values. At the same time, the morphological characteristics of the FP in the midlateral region of the tongue were recorded with a digital microscope. Results: One month after surgery, EGM showed no response in any patients. At a time point of more than 2 years, the FP showed complete atrophy and no response to EGM on the surgical side in 21 of the 54 patients. In 16 patients who showed complete recovery of the EGM threshold (below 20 mu A), the FP showed an almost normal appearance, and the mean number of FP was 77.5% (10 +/- 4.1 papillae per square centimeter) of that on the contralateral side (12.9 +/- 4.9 papillae per square centimeter; p>0.05). Conclusions: The morphology of the FP was maintained in patients who recovered gustatory function after the chorda tympani nerve was severed. Because the results indicate regeneration of the taste buds, further observation is needed to detect regenerated taste buds in the FP. C1 [Saito, Takehisa; Narita, Norihiko; Yamada, Takechiyo] Univ Fukui, Dept Otolaryngol Head & Neck Surg, Eiheiji, Fukui 9101193, Japan. [Ito, Tetsufumi] Univ Fukui, Dept Anat, Eiheiji, Fukui 9101193, Japan. [Saito, Takehisa] Univ Fukui, Fac Med, Eiheiji, Fukui 9101193, Japan. [Saito, Takehisa] Univ Fukui, Res & Educ Program Life Sci, Eiheiji, Fukui 9101193, Japan. [Manabe, Yasuhiro] Shinseikai Toyama Hosp, Dept Otolaryngol, Toyama, Japan. RP Saito, T (reprint author), Univ Fukui, Dept Otolaryngol Head & Neck Surg, Matsuoka Shimoaizuki 23-3, Eiheiji, Fukui 9101193, Japan. FU Ministry of Education, Science and Culture, Japan [18591861] FX From the Departments of Otolaryngology Head and Neck Surgery (Saito, Narita, Yamada) and Anatomy (Ito), Faculty of Medicine, and the Research and Education Program for Life Science (Saito), University of Fukui, Fukui, and the Department of Otolaryngology, Shinseikai Toyama Hospital, Toyama (Manabe), Japan. This study was supported by a Grant-in-Aid for Scientific Research (C) (No.18591861) from the Ministry of Education, Science and Culture, Japan. CR Berteretche MV, 2008, EUR J ORAL SCI, V116, P394, DOI 10.1111/j.1600-0722.2008.00556.x BLISS CI, 1953, BIOMETRICS, V9, P176, DOI 10.2307/3001850 BULL T R, 1965, J Laryngol Otol, V79, P479, DOI 10.1017/S0022215100063969 FARBMAN AI, 1967, ANAT REC, V157, P242 GARDNER W, 1995, PSYCHOL BULL, V118, P392, DOI 10.1037//0033-2909.118.3.392 Hard af Segerstad C, 1989, CHEM SENSES, V14, P335 Ishii T, 1979, Nihon Jibiinkoka Gakkai Kaiho, V82, P271 Just T, 2006, LARYNGOSCOPE, V116, P1216, DOI 10.1097/01.mlg.0000224509.61099.29 KUKIMOTO N, 1986, Nihon University Journal of Medicine, V28, P121 Miller Jr IJ, 1991, SMELL TASTE HLTH DIS, P205 Miller SL, 2002, PHYSIOL BEHAV, V75, P753, DOI 10.1016/S0031-9384(02)00672-8 Moon CN, 1963, LARYNGOSCOPE, V73, P392 Murray R, 1973, ULTRASTRUCTURE SENSO, P1 Nagato T, 1995, ACTA ANAT, V153, P301 NAGATO T, 1993, J JPN STOMATOL SOC, V42, P223 Nin T, 2006, AURIS NASUS LARYNX, V33, P13, DOI 10.1016/j.anl.2005.07.015 Saito Takehisa, 2000, Annals of Otology Rhinology and Laryngology, V109, P703 Saito T, 2001, LARYNGOSCOPE, V111, P2064, DOI 10.1097/00005537-200111000-00037 Saito T, 2002, ANN OTO RHINOL LARYN, V111, P357 Saito T, 2001, ORL J OTO-RHINO-LARY, V63, P359, DOI 10.1159/000055774 Stillman JA, 2003, CLIN OTOLARYNGOL, V28, P406, DOI 10.1046/j.1365-2273.2003.00729.x Tomita H, 1986, AURIS NASUS LARYNX S, V13, P1 ZUNIGA JR, 1994, CHEM SENSES, V19, P657, DOI 10.1093/chemse/19.6.657 NR 23 TC 4 Z9 4 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD MAY PY 2011 VL 120 IS 5 BP 300 EP 306 PG 7 WC Otorhinolaryngology SC Otorhinolaryngology GA 767FM UT WOS:000290840700004 PM 21675585 ER PT J AU Buiret, G Colin, C Landry, G Poupart, M Pignat, JC AF Buiret, Guillaume Colin, Carole Landry, Guillaume Poupart, Marc Pignat, Jean-Christian TI Determination of Predictive Factors of Tracheobronchial Prosthesis Removal: Stent Brands Are Crucial SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article; Proceedings Paper CT Annual Meeting of the American-Broncho-Esophagological-Association CY APR 28-29, 2010 CL Las Vegas, NV SP Amer Broncho Esophagol Assoc DE bronchoscopy; stent; upper airway ID SILICONE STENTS; AIRWAY COMPLICATIONS; LUNG TRANSPLANTATION; ENDOBRONCHIAL STENT; MANAGEMENT; PLACEMENT; BRONCHOSCOPY; STENOSES; OBSTRUCTIONS; STRICTURES AB Objectives: We sought to describe in a retrospective study our experience in the endoscopic management of tracheobronchial stenoses over 20 years and to determine prognostic factors of stem removal. Methods: We analyzed the medical records of 166 patients (111 male and 55 female) who underwent the placement of a prosthesis for all causes of tracheobronchial stenosis between 1990 and 2009. Results: Overall, 34% of the patients had their stents removed. The incidence of complications for the first stent was 0.08 per patient-month. One hundred five patients (63%) had no complications. In univariate analysis, stent removal was significantly linked with the stein brand. In multivariate analysis, taking into account the causes of stenosis, the stent brand appeared to be the only factor that significantly influenced stent removal. Finally, stenosis with more than I stent replacement was most prone to repeat endoscopies. Conclusions: Even though endoscopic stent placement is a relatively safe and effective treatment for tracheobronchial stenoses, particularly in cases with malignancy, complications led to stent removal in about one third of cases. The type of stein chosen is crucial. C1 [Buiret, Guillaume; Colin, Carole; Landry, Guillaume; Poupart, Marc; Pignat, Jean-Christian] Ctr Hosp Univ Lyon, Hop Croix Rousse, Otorhinolaryngol & Cervicofacial Surg Unit, F-69004 Lyon, France. [Buiret, Guillaume; Colin, Carole; Landry, Guillaume; Pignat, Jean-Christian] Univ Lyon 1, Lyon, France. RP Buiret, G (reprint author), Ctr Hosp Univ Lyon, Hop Croix Rousse, Otorhinolaryngol & Cervicofacial Surg Unit, 104 Grande Rue Croix Rousse, F-69004 Lyon, France. CR Abdullah V, 1998, OTOLARYNG HEAD NECK, V118, P256, DOI 10.1016/S0194-5998(98)80027-2 Bolliger CT, 2006, EUR RESPIR J, V27, P1258, DOI 10.1183/09031936.06.00013906 Monnier P, 1996, CHEST, V110, P1161, DOI 10.1378/chest.110.5.1161 Chhajed PN, 2001, CHEST, V120, P1894, DOI 10.1378/chest.120.6.1894 Chin CS, 2008, ANN THORAC SURG, V85, pS792, DOI 10.1016/j.athoracsur.2007.11.051 Dasgupta A, 1998, CHEST, V114, P106, DOI 10.1378/chest.114.1.106 Eckel HE, 2003, LARYNGOSCOPE, V113, P11, DOI 10.1097/00005537-200301000-00002 Gaissert HA, 2003, J THORAC CARDIOV SUR, V126, P744, DOI 10.1016/S0022-5223(03)00361-1 Herth F, 2001, CHEST, V119, P1910, DOI 10.1378/chest.119.6.1910 Kapoor BS, 2007, J VASC INTERV RADIOL, V18, P629, DOI 10.1016/j.jvir.2007.02.021 Lemaire A, 2005, ANN THORAC SURG, V80, P434, DOI 10.1016/j.athoracsur.2005.02.071 Makris D, 2007, CURR OPIN PULM MED, V13, P278, DOI 10.1097/MCP.0b013e32816b5c3b MartinezBallarin JI, 1996, CHEST, V109, P626, DOI 10.1378/chest.109.3.626 Merrot O, 2008, LARYNGOSCOPE, V118, P403, DOI 10.1097/MLG.0b013e31815d8e79 Miyazawa T, 2000, CHEST, V118, P959, DOI 10.1378/chest.118.4.959 MONTGOME.WW, 1965, ARCHIV OTOLARYNGOL, V82, P320 Ryu YJ, 2006, EUR RESPIR J, V28, P1029, DOI 10.1183/09031936.00020906 Saad CP, 2003, CHEST, V124, P1993, DOI 10.1378/chest.124.5.1993 Shin JH, 2003, J VASC INTERV RADIOL, V14, P1525, DOI 10.1097/01.RVI.0000099525.29957.34 Spinelli P, 1998, Minerva Chir, V53, P373 VERGNON JM, 1995, CHEST, V107, P741, DOI 10.1378/chest.107.3.741 Vergnon JM, 2008, REV MAL RESP, V25 Vonk-Noordegraaf A, 2001, CHEST, V120, P1811, DOI 10.1378/chest.120.6.1811 Walser EM, 2005, EUR J RADIOL, V55, P321, DOI 10.1016/j.ejrad.2005.03.005 Walser EM, 2004, J VASC INTERV RADIOL, V15, P471, DOI 10.1097/01.RVI.0000124944.58200.D9 Xu Xiangying, 2001, Journal of Nippon Medical School, V68, P318, DOI 10.1272/jnms.68.318 Yerushalmi R, 2006, ISRAEL MED ASSOC J, V8, P615 NR 27 TC 0 Z9 0 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD MAY PY 2011 VL 120 IS 5 BP 307 EP 313 PG 7 WC Otorhinolaryngology SC Otorhinolaryngology GA 767FM UT WOS:000290840700005 PM 21675586 ER PT J AU Song, JE Tanaka, SM Pinto, JM Rasmussen, B Ferro, LM Saadia-Redleaf, MI AF Song, James E. Tanaka, Sara M. Pinto, Jayant M. Rasmussen, Beth Ferro, Lia M. Saadia-Redleaf, Miriam I. TI Long-Term Effects of Hearing Aids on Word Recognition Scores SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE bilateral symmetric hearing loss; hearing aid; sensorineural hearing loss; word recognition ID AUDITORY DEPRIVATION; ACCLIMATIZATION; AMPLIFICATION AB Objectives: The purpose of this study was to retrospectively examine how monaurally fitted hearing aids affected word recognition scores in patients with bilateral symmetric sensorineural hearing loss. Methods: Sixty-six patients from 2 separate institutions were included in this study. In addition to having bilateral symmetric sensorineural hearing loss due to presbycusis, each patient had to have worn a single hearing aid for at least 5 months and have valid pre-aid and post-aid audiograms. Word recognition scores were analyzed with a table of confidence levels generated by Thornton and Raffin that determined the probability of differences between word recognition scores. Results: Hearing aids did not improve or preserve word recognition scores to the degree that has been previously reported in the literature. The unaided (control) ear demonstrated a decrease in word recognition scores over time, as was expected from previous studies. The aided ears demonstrated a similar decline in word recognition scores when compared to the unaided ears. When the conventional confidence level of 0.05 was used, the aided ears showed no advantage over the unaided (control) ears. Conclusions: These findings are not consistent with the acclimatization first reported by Silman et al in 1993. Such a discrepancy in the results calls for further studies to evaluate just how effective unilateral hearing aids are in patients with bilateral symmetric sensorineural hearing loss. C1 [Saadia-Redleaf, Miriam I.] Univ Illinois, Dept Otolaryngol Head & Neck Surg, Eye & Ear Infirm, Chicago, IL 60612 USA. [Tanaka, Sara M.] Univ Chicago, Med Ctr, Dept Med, Chicago, IL 60637 USA. [Pinto, Jayant M.; Ferro, Lia M.] Univ Chicago, Med Ctr, Sect Otolaryngol Head & Neck Surg, Chicago, IL 60637 USA. RP Saadia-Redleaf, MI (reprint author), Univ Illinois, Dept Otolaryngol Head & Neck Surg, Eye & Ear Infirm, 1855 W Taylor St,Room 2-42, Chicago, IL 60612 USA. CR Arlinger S, 1996, EAR HEARING, V17, pS87, DOI 10.1097/00003446-199617031-00009 Cox R M, 1996, J Am Acad Audiol, V7, P428 Dieroff H G, 1993, J Am Acad Audiol, V4, P347 GATEHOUSE S, 1992, J ACOUST SOC AM, V92, P1258, DOI 10.1121/1.403921 GATEHOUSE S, 1989, J ACOUST SOC AM, V86, P2103, DOI 10.1121/1.398469 GELFAND SA, 1987, SCAND AUDIOL, V16, P201, DOI 10.3109/01050398709074941 Hurley R M, 1993, J Am Acad Audiol, V4, P285 RAFFIN MJM, 1980, J SPEECH HEAR RES, V23, P5 SILMAN S, 1993, J REHABIL RES DEV, V30, P326 Silverman C A, 1993, J Am Acad Audiol, V4, P338 Silverman CA, 2006, J AM ACAD AUDIOL, V17, P747, DOI 10.3766/jaaa.17.10.6 NR 11 TC 0 Z9 0 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD MAY PY 2011 VL 120 IS 5 BP 314 EP 319 PG 6 WC Otorhinolaryngology SC Otorhinolaryngology GA 767FM UT WOS:000290840700006 PM 21675587 ER PT J AU Habesoglu, TE Habesoglu, M Deveci, I Kulekci, S Kalaycik, C Gokceer, T Egeli, E AF Habesoglu, Tulay Erden Habesoglu, Mehmet Deveci, Ildem Kulekci, Semra Kalaycik, Cigdem Gokceer, Tanju Egeli, Erol TI Effect of Type I Tympanoplasty on the Quality of Life of Children SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE pediatric otolaryngology; quality of life; tympanoplasty ID OTITIS-MEDIA; PEDIATRIC TYMPANOPLASTY; MYRINGOPLASTY; LANGUAGE; OUTCOMES; SPEECH AB Objectives: Quality-of-life issues related to chronic otitis media (COM) include physical symptoms, emotional symptoms, hearing loss, speech symptoms, social symptoms, and parents' emotional symptoms. In this study we evaluated the effects of tympanoplasty on the quality of life of pediatric patients. Methods: In a questionnaire-based outcome study, we reviewed 56 of 78 pediatric patients with COM who were treated with type I tympanoplasty at our institution between December 2008 and February 2010. All patients were asked to fill out the COM-5 questionnaire with their parents, before operation and 6 months after operation. Preoperative and postoperative total ear scores, preoperative and postoperative ear scores with an intact tympanic membrane, preoperative and postoperative ear scores with a perforated tympanic membrane, and preoperative and postoperative audiological results were assessed. Results: After type I tympanoplasty, 45 patients (80.3%) had successful closure of the tympanic membrane, but 11 patients (19.7%) had unsuccessful closure of the tympanic membrane. There was a significant decrease in physical suffering, hearing loss, emotional distress, activity limitations, and caregiver's concerns scores in patients with intact tympanic membranes after operation (p<0.01). Conclusions: Children with COM had a significant increase in their quality of life after successful tympanoplasty. Our results also suggested that tympanoplasty was successful in pediatric patients with COM. C1 [Habesoglu, Tulay Erden; Habesoglu, Mehmet; Deveci, Ildem; Kulekci, Semra; Kalaycik, Cigdem; Egeli, Erol] Haydarpasa Numune Educ & Res Hosp, Dept Otolaryngol Head & Neck Surg 2, Istanbul, Turkey. [Gokceer, Tanju] Haydarpasa Numune Educ & Res Hosp, Dept Otolaryngol Head & Neck Surg 1, Istanbul, Turkey. RP Habesoglu, TE (reprint author), Haydarpasa Numune Educ & Res Hosp, Dept Otolaryngol Head & Neck Surg, Istanbul, Turkey. CR BLUESTONE CD, 1979, LARYNGOSCOPE, V89, P450 Caylan R, 1998, OTOLARYNG HEAD NECK, V118, P709, DOI 10.1177/019459989811800529 Chole RA, 1998, OTOLARYNGOLOGY HEAD, P3026 Collins WO, 2003, ARCH OTOLARYNGOL, V129, P646, DOI 10.1001/archotol.129.6.646 JAHN AF, 1991, MED CLIN N AM, V75, P1277 PICCIRILLO JF, 1994, OTOLARYNG HEAD NECK, V111, P764, DOI 10.1016/S0194-5998(94)70565-8 Rosenfeld RM, 1997, ARCH OTOLARYNGOL, V123, P1049 Rosenfeld RM, 2000, ARCH OTOLARYNGOL, V126, P585 SHIH L, 1991, OTOLARYNG HEAD NECK, V105, P74 TEELE DW, 1990, J INFECT DIS, V162, P685 TEELE DW, 1984, PEDIATRICS, V74, P282 Vlastos IM, 2009, INT J PEDIATR OTORHI, V73, P363, DOI 10.1016/j.ijporl.2008.10.030 Vrabec JT, 1999, ARCH OTOLARYNGOL, V125, P530 NR 13 TC 2 Z9 3 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD MAY PY 2011 VL 120 IS 5 BP 326 EP 330 PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA 767FM UT WOS:000290840700008 PM 21675589 ER PT J AU Old, MO Oh, SS Feldman, E Hogikyan, ND AF Old, Matthew O. Oh, Sang Su Feldman, Eva Hogikyan, Norman D. TI Novel Model to Assess Laryngeal Function, Innervation, and Reinnervation SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE laryngeal innervation; nucleus ambiguus; rat laryngeal anatomy; recurrent laryngeal nerve; reinnervation; superior laryngeal nerve ID RAT LARYNX; AGED RATS; MUSCLES; SYNKINESIS; NERVE; DENERVATION AB Objectives: Laryngeal paralysis remains an unsolved problem, and the behavior of the laryngeal muscles following injury to the native innervation appears to be a function of denervation and reinnervation. The aim of the present study was to develop a reliable, accurate, and multifaceted animal model for study of laryngeal function, innervation, and reinnervation. Methods: A spontaneous-breathing anesthesia technique, suspension laryngoscopy, endoscopic evaluation of the rat larynx, and transoral injection of a retrograde neuronal tracer, hydroxystilbamidine (FluoroGold), were developed. We submitted 14 rats to the developed technique to map the brain stem projections of the superior laryngeal nerve and the recurrent laryngeal nerve and to determine the feasibility and accuracy of the endoscopic injection technique. Results: This endoscopic technique provided full evaluation of the rat larynx. We performed transoral endoscopic injection of FluoroGold and transcervical application of the tracer to transected superior laryngeal and recurrent laryngeal nerves in 14 different rats and successfully created a neural projection map for the superior laryngeal nerve, the recurrent laryngeal nerve, and the cervical ganglia. Conclusions: A reliable, accurate model for the characterization of laryngeal function, routes of innervation, and sources of spontaneous reinnervation following recurrent laryngeal nerve resection has been developed. This stable and reproducible model can serve as a dependable tool in future investigations of laryngeal nerve injury and recovery. C1 [Old, Matthew O.; Hogikyan, Norman D.] Univ Michigan, Dept Otolaryngol Head & Neck Surg, Ann Arbor, MI 48109 USA. [Oh, Sang Su; Feldman, Eva] Univ Michigan, Dept Neurol, Ann Arbor, MI 48109 USA. RP Old, MO (reprint author), Ohio State Univ, 456 W 10th Ave,Cramblett Hall,Suite 4A, Columbus, OH 43210 USA. RI Old, Matthew/E-3783-2011 CR Blitzer A, 1996, ANN OTO RHINOL LARYN, V105, P764 Broniatowski M, 2010, LARYNGOSCOPE, V120, P76, DOI 10.1002/lary.20698 Broniatowski M, 2008, LARYNGOSCOPE, V118, P1889, DOI 10.1097/MLG.0b013e31817e7452 Crumley RL, 2000, ANN OTO RHINOL LARYN, V109, P365 CRUMLEY RL, 1982, OTOLARYNG HEAD NECK, V90, P442 Erman AB, 2009, SEMIN NEUROL, V29, P85, DOI 10.1055/s-0028-1124027 FLINT PW, 1991, ANN OTO RHINOL LARYN, V100, P797 Fried M, 2009, LARYNX Hirasugi K, 2007, ACTA OTO-LARYNGOL, V127, P213, DOI 10.1080/00016480600794479 Hydman J, 2008, MUSCLE NERVE, V38, P1280, DOI 10.1002/mus.21124 Hydman J, 2005, LARYNGOSCOPE, V115, P619, DOI 10.1097/01.mlg.0000161362.43320.b2 Inagi K, 1998, LARYNGOSCOPE, V108, P1048, DOI 10.1097/00005537-199807000-00018 Inagi K, 1998, OTOLARYNG HEAD NECK, V118, P74, DOI 10.1016/S0194-5998(98)70378-X Iroto I, 1968, Ann Otol Rhinol Laryngol, V77, P296 Liu HJ, 2005, LARYNGOSCOPE, V115, P1418, DOI 10.1097/01.mlg.0000167982.07597.df Nagai H, 2005, AM J OTOLARYNG, V26, P377, DOI 10.1016/j.amjoto.2005.02.015 NOMOTO M, 1993, ACTA OTO-LARYNGOL, P71 NOMOTO M, 1991, BRAIN RES, V539, P276, DOI 10.1016/0006-8993(91)91632-B SHINDO ML, 1992, LARYNGOSCOPE, V102, P663, DOI 10.1288/00005537-199206000-00012 Suzuki T, 2002, ANN OTO RHINOL LARYN, V111, P684 NR 20 TC 3 Z9 3 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD MAY PY 2011 VL 120 IS 5 BP 331 EP 338 PG 8 WC Otorhinolaryngology SC Otorhinolaryngology GA 767FM UT WOS:000290840700009 PM 21675590 ER PT J AU Calli, C Pinar, E Oncel, S AF Calli, Caglar Pinar, Ercan Oncel, Semih TI Pharyngocutaneous Fistula After Total Laryngectomy: Less Common With Mechanical Stapler Closure SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE laryngectomy; manual suturing; mechanical closure; pharyngocutaneous fistula; stapler ID PREDISPOSING FACTORS; LINEAR STAPLER; EXPERIENCE; EMPHASIS; DEVICE AB Objectives: The aim of the study was to compare the incidences of pharyngocutaneous fistula after total laryngectomy between patients who underwent manual and mechanical suturing for pharyngoesophageal closure. Methods: In a retrospective and prospective nonrandomized clinical study conducted at a single tertiary medical center between May 2002 and April 2009, we compared the incidence of pharyngocutaneous salivary fistula between two groups of patients after total laryngectomy. Sixty-one consecutive patients who underwent mechanical suturing with a 60-mm linear stapler (group A) were prospectively enrolled, and 121 patients who had undergone manual suturing (group B) were retrospectively reviewed. Results: The groups were similar in terms of age, gender, comorbidities, TNM (tumor, node, metastasis) stage, and laryngeal tumor extension. The incidence of pharyngocutaneous salivary fistula was 4.9% in group A and 19.8% in group B (p = 0.014). Conclusions: Mechanical stapler closure of the pharynx after total laryngectomy was associated with a significant reduction in the incidence of pharyngocutaneous fistula compared with manual suture in selected cases. C1 [Calli, Caglar; Pinar, Ercan; Oncel, Semih] Izmir Training & Res Hosp, Dept Otorhinolaryngol Head & Neck Surg, Izmir, Turkey. RP Calli, C (reprint author), Ankara Cad 137-31, TR-35030 Izmir, Turkey. CR Agrawal A, 2000, LARYNGOSCOPE, V110, P1402, DOI 10.1097/00005537-200008000-00034 Akyol M U, 1995, Ear Nose Throat J, V74, P28 Bedrin L, 2005, HEAD NECK-J SCI SPEC, V27, P1073, DOI 10.1002/hed.20280 Cavalot AL, 2000, OTOLARYNG HEAD NECK, V123, P587, DOI 10.1067/mhn.2000.110617 Goncalves AJ, 2009, EUR ARCH OTO-RHINO-L, V266, P1793, DOI 10.1007/s00405-009-0945-4 HOEHN JG, 1969, MAYO CLIN PROC, V44, P738 Ikiz AO, 2000, J LARYNGOL OTOL, V114, P768 Layland Michael K, 2005, Laryngoscope, V115, P629 Luk'ianchenko A G, 1971, Vestn Otorinolaringol, V33, P29 Parikh SR, 1998, J OTOLARYNGOL, V27, P136 Pinar E, 2008, J OTOLARYNGOL-HEAD N, V37, P312, DOI 10.2310/7070.2008.0064 Qureshi S S, 2005, J Cancer Res Ther, V1, P51 Saki N, 2008, ARCH IRAN MED, V11, P314, DOI 08113/AIM.0013 Santaolalla Montoya F, 2002, ACTA OTORRINOLARINGO, V53, P343 Sofferman RA, 2000, LARYNGOSCOPE, V110, P1406, DOI 10.1097/00005537-200008000-00035 WESTMORE GA, 1983, J LARYNGOL OTOL, V97, P775, DOI 10.1017/S0022215100094974 NR 16 TC 7 Z9 9 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD MAY PY 2011 VL 120 IS 5 BP 339 EP 344 PG 6 WC Otorhinolaryngology SC Otorhinolaryngology GA 767FM UT WOS:000290840700010 PM 21675591 ER PT J AU Hu, GH Zhong, SX Xiao, Q Li, ZW Hong, SL AF Hu, Guohua Zhong, Shixun Xiao, Qing Li, Zhongwan Hong, Suling TI Radiolocalization of Sentinel Lymph Nodes in Clinically N0 Laryngeal and Hypopharyngeal Cancers SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE hypopharyngeal cancer; laryngeal cancer; radioactive tracer; sentinel lymph node biopsy ID BREAST-CANCER; CUTANEOUS MELANOMA; NECK-CANCER; BIOPSY; LYMPHOSCINTIGRAPHY; METASTASES; HEAD; NUMBER AB Objectives: We sought to analyze the characteristics of radioactive lymph nodes with metastatic disease and to explore methods for the localization of sentinel lymph nodes (SLNs) with radionuclide in clinically NO laryngeal and hypopharyngeal cancer. Methods: Forty-five patients with T1-T4 and clinically NO laryngeal and hypopharyngeal cancer were recruited. For each patient, a peritumoral submucosal injection of (99m)qc-labeled sulfur colloid was administered, and lymph node mapping was performed by lymphoscintigraphy 2 hours after injection. The SLNs were localized during operation by a hand-held gamma probe 10 to 12 hours after the injection, and we defined the radioactive counts from the parotideomasseteric region as background values. All lymph nodes that had accumulated radioactivity were harvested and initially termed as SLNs. Selective neck dissection was performed in all patients. The SLN specimens were sent for formal paraffin embedded sectioning, serial sectioning, and immunohistochemical assay. The results were compared to those for the remaining lymphadenectomy specimen. Resection of the primary tumor depended on its location and the T classification. Results: Sentinel lymph nodes were identified in 41 of 45 patients (51 necks). Sentinel lymph nodes with occult metastases were found in 13 patients (15 necks). In a false-negative case, metastasis was found in a nonsentinel lymph node in I of the neck specimens. The SLN identification rate was 92.7%, the sensitivity was 93.7%, the false-negative rate was 6.3%, and the accuracy was 98.0%. In II of the 15 necks (73.3%) with pathologically positive SLNs, metastasis was found in the node with the highest radioactivity. Harvesting the first 3 nodes with the highest radioactive counts may identify patients with occult metastatic disease. Conclusions: Excision of the first 3 SLNs with the highest radioactive counts can be used to accurately identify the status of cervical lymph node metastases in patients with clinically NO laryngeal or hypopharyngeal cancer. C1 [Hu, Guohua; Zhong, Shixun; Li, Zhongwan; Hong, Suling] Chongqing Med Univ, Dept Otolaryngol, Affiliated Hosp 1, Chongqing 400016, Peoples R China. [Xiao, Qing] Chongqing Med Univ, Dept Hematol, Affiliated Hosp 1, Chongqing 400016, Peoples R China. RP Hu, GH (reprint author), Chongqing Med Univ, Dept Otolaryngol, Affiliated Hosp 1, Chongqing 400016, Peoples R China. CR Anan K, 2000, EUR J SURG, V166, P610 Bourgeois P, 2003, NUCL MED COMMUN, V24, P513, DOI 10.1097/01.mnh.0000071244.54690.33 CHOW JM, 1989, ARCH OTOLARYNGOL, V115, P981 Clary BM, 2001, ANN SURG, V233, P250, DOI 10.1097/00000658-200102000-00015 De Cicco C, 1998, J NUCL MED, V39, P2080 Eshima D, 2000, SEMIN NUCL MED, V30, P25 FLETCHER GH, 1984, CANCER, V53, P1274, DOI 10.1002/1097-0142(19840315)53:6<1274::AID-CNCR2820530610>3.0.CO;2-U Goldhirsch A, 1998, J NATL CANCER I, V90, P1601, DOI 10.1093/jnci/90.21.1601 Hoft S, 2004, BRIT J CANCER, V91, P124, DOI 10.1038/sj.bjc.6601877 Jin WL, 2008, CHINESE MED J-PEKING, V121, P1871 Kontio R, 2004, HEAD NECK-J SCI SPEC, V26, P16, DOI 10.1002/hed.10355 Krag D, 1998, NEW ENGL J MED, V339, P941, DOI 10.1056/NEJM199810013391401 Maffioli L, 2000, TUMORI, V86, P341 Martin RCG, 2001, ANN SURG ONCOL, V8, P592, DOI 10.1245/aso.2001.8.7.592 *NCCN, 2008, NCCN NAT COMPR CANC Petrović Zeljko, 2008, Med Pregl, V61, P242 Sarno A, 2004, ACTA OTO-LARYNGOL, V124, P980, DOI 10.1080/00016480410017341 Tomifuji M, 2008, ANN SURG ONCOL, V15, P2568, DOI 10.1245/s10434-008-0008-x TU GY, 1998, CHIN J OTORHINOLAR S, V33, P63 Werner JA, 2002, EUR ARCH OTO-RHINO-L, V259, P91, DOI 10.1007/s00405-001-0421-2 Wong SL, 2001, J AM COLL SURGEONS, V192, P684, DOI 10.1016/S1072-7515(01)00858-4 Yeung HWD, 2001, J NUCL MED, V42, P420 NR 22 TC 5 Z9 5 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD MAY PY 2011 VL 120 IS 5 BP 345 EP 350 PG 6 WC Otorhinolaryngology SC Otorhinolaryngology GA 767FM UT WOS:000290840700011 PM 21675592 ER PT J AU Leong, SC Waugh, LK Sinha, A De, S AF Leong, Samuel Chee Waugh, Lucy-Katherine Sinha, Ajay De, Sujata TI Clinical Outcomes of Sinogenic Intracranial Suppuration: The Alder Hey Experience SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE abscess; intracranial suppuration; paranasal sinus; sinusitis; subdural empyema ID FRONTAL SINUSITIS; SUBDURAL EMPYEMA; COMPLICATIONS; CHILDREN; ABSCESSES; MANAGEMENT AB Objectives: The aim of this study was to present a series of cases of sinogenic intracranial suppuration in a pediatric tertiary referral center and to review the long-term outcomes of the patients. Methods: We performed a retrospective review of the hospital database and the patient case notes. Results: Over 10 years, 14 patients were identified. The clinical presentations at the time of admission tended to include headache, vomiting, pyrexia, limb weakness, and decreased level of consciousness, in decreasing order of frequency. Sinonasal symptoms such as discharge and obstruction were only present in 36% and 21% of cases, respectively. The most common intracranial complication was subdural empyema in the frontal lobe region. The mortality rate was 21% (3 of 14). The remaining II patients remained alive at latest follow-up. The average follow-up period after hospital discharge was 19 months (median, 15 months; range, 6 to 64 months). No significant complications were noted in 4 patients, who had returned to normal daily activities at 6 months of follow-up. A significant proportion of patients who survived have some form of neurologic sequelae, although 64% of cases became asymptomatic in the 12 months following hospital discharge. Conclusions: The significant risk of morbidity and mortality of this disease requires a multidisciplinary approach that is best delivered at a tertiary referral center. C1 [Leong, Samuel Chee; De, Sujata] Alder Hey Childrens Natl Hlth Serv Fdn Trust, Dept Otorhinolaryngol, Liverpool L12 2AP, Merseyside, England. [Waugh, Lucy-Katherine] Alder Hey Childrens Natl Hlth Serv Fdn Trust, Dept Infect Dis, Liverpool L12 2AP, Merseyside, England. [Sinha, Ajay] Alder Hey Childrens Natl Hlth Serv Fdn Trust, Dept Neurosurg, Liverpool L12 2AP, Merseyside, England. RP Leong, SC (reprint author), Alder Hey Childrens Natl Hlth Serv Fdn Trust, Dept Otorhinolaryngol, Liverpool L12 2AP, Merseyside, England. CR Adame N, 2005, PEDIATRICS, V116, pE461, DOI 10.1542/peds.2004-2501 Bayonne E, 2009, RHINOLOGY, V47, P59 Brook I, 2005, ARCH OTOLARYNGOL, V131, P1017, DOI 10.1001/archotol.131.11.1017 DelGaudio JM, 2010, AM J OTOLARYNG, V31, P25, DOI 10.1016/j.amjoto.2008.09.009 Dolan R W, 1995, J Oral Maxillofac Surg, V53, P1080, DOI 10.1016/0278-2391(95)90128-0 Fenton JE, 1999, AM J RHINOL, V13, P299, DOI 10.2500/105065899782102854 Germiller JA, 2006, ARCH OTOLARYNGOL, V132, P969, DOI 10.1001/archotol.132.9.969 Giannoni C, 1998, AM J RHINOL, V12, P173, DOI 10.2500/105065898781390127 Glickstein JS, 2006, OTOLARYNG HEAD NECK, V134, P733, DOI 10.1016/j.otohns.2005.12.001 Heran NS, 2003, NEUROSURGERY, V53, P893, DOI 10.1227/01.NEU.0000084163.51521.58 Jones NS, 2002, LARYNGOSCOPE, V112, P59, DOI 10.1097/00005537-200201000-00011 Kuczkowski J, 2005, CLIN PEDIATR, V44, P675, DOI 10.1177/000992280504400805 Lang EE, 2001, CLIN OTOLARYNGOL, V26, P452, DOI 10.1046/j.1365-2273.2001.00499.x McIntosh DL, 2007, INT J PEDIATR OTORHI, V71, P1573, DOI 10.1016/j.ijporl.2007.06.011 Ong YK, 2002, INT J PEDIATR OTORHI, V66, P49 Osborn MK, 2007, LANCET INFECT DIS, V7, P62, DOI 10.1016/S1473-3099(06)70688-0 Oxford LE, 2005, OTOLARYNG HEAD NECK, V133, P32, DOI 10.1016/j.otohns.2005.03.020 Quraishi H, 2006, INT J PEDIATR OTORHI, V70, P1581, DOI 10.1016/j.ijporl.2006.04.007 SINGH B, 1995, J LARYNGOL OTOL, V109, P945 Smith SJ, 2009, BRIT J NEUROSURG, V23, P412, DOI 10.1080/02688690902887549 Sultesz M, 2009, INT J PEDIATR OTORHI, V73, P1507, DOI 10.1016/j.ijporl.2009.04.027 Tandon S, 2009, J LARYNGOL OTOL, V123, P283, DOI 10.1017/S002221510800234X NR 22 TC 1 Z9 1 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD MAY PY 2011 VL 120 IS 5 BP 320 EP 325 PG 6 WC Otorhinolaryngology SC Otorhinolaryngology GA 767FM UT WOS:000290840700007 PM 21675588 ER PT J AU Seybt, MW Terris, DJ AF Seybt, Melanie W. Terris, David J. TI Minimally Invasive Thyroid Surgery in Children SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE cosmesis; endoscopy; minimally invasive surgery; pediatrics; scar; thyroid gland; thyroidectomy ID VIDEO-ASSISTED THYROIDECTOMY; AXILLARY APPROACH; EXPERIENCE; LOBECTOMY; DISEASE; CANCER; SAFE AB Objectives: As the prevalence of thyroid nodules and thyroid cancer increases, thyroid surgery is being performed in a growing number of pediatric patients. Minimally invasive thyroid surgery may be particularly beneficial in this patient population. Smaller incisions result in improved cosmesis in this young, predominantly female group, and minimal-access techniques better preserve tissue planes - an advantage, because of younger patients' higher lifetime likelihood of reoperation. Methods: For this case series with planned data collection, Institutional Review Board approval was obtained to analyze a prospective database and assess outcome data. The outcome measures included pathologic classification, cosmetic results, rates of complications (especially hypocalcemia), true vocal fold paralysis, and the need for admission or readmission. Results: We performed 495 thyroidectomy procedures during the study period (February 2003 to May 2008). Of these, 23 were in patients less than 21 years of age. The mean incision length was 3.3 +/- 1.0 cm (range, 1.5 to 5.0 cm), and 12 of the incisions (52.2%) were 3 cm or shorter. Nine patients (41%) had thyroid cancer, most commonly papillary carcinoma (compared with 21.9% of the adult population). There were no hematomas and no cases of permanent true vocal fold paralysis or permanent hypocalcemia. Two patients (8.7%) had temporary hypocalcemia, and both required readmission. Conclusions: Minimally invasive thyroid surgery has benefits over conventional thyroid surgery, particularly in a pediatric population. Among its many potential advantages, the social stigma of a large incision is reduced and preservation of tissue planes is improved. C1 [Seybt, Melanie W.; Terris, David J.] Med Coll Georgia, Dept Otolaryngol Head & Neck Surg, MCG Thyroid Ctr, Augusta, GA 30912 USA. RP Terris, DJ (reprint author), Med Coll Georgia, Dept Otolaryngol Head & Neck Surg, MCG Thyroid Ctr, 1120 15th St,BP-4109, Augusta, GA 30912 USA. CR Bargren AE, 2009, J SURG RES, V156, P70, DOI 10.1016/j.jss.2009.03.088 Bellantone R, 1999, AM J SURG, V177, P342, DOI 10.1016/S0002-9610(99)00054-9 Berti P, 2004, SURG ENDOSC, V18, P1208, DOI 10.1007/s00464-003-9225-3 Defechereux T, 2003, ACTA CHIR BELG, V103, P274 FESTEN C, 1995, EUR J PEDIATR SURG, V5, P262, DOI 10.1055/s-2008-1066220 Ikeda Y, 2000, J AM COLL SURGEONS, V191, P336, DOI 10.1016/S1072-7515(00)00342-2 Kang SW, 2009, ENDOCR J, V56, P361 Miccoli P, 2004, J AM COLL SURGEONS, V199, P243, DOI 10.1016/j.jamcollsurg.2004.03.025 Randolph GW., 2003, SURG THYROID PARATHY, P300 Raval MV, 2009, J PEDIATR SURG, V44, P1529, DOI 10.1016/j.jpedsurg.2008.11.032 Ringel MD, 2003, ANN SURG ONCOL, V10, P4, DOI 10.1245/ASO.2003.11.002 Sebag F, 2006, WORLD J SURG, V30, P802, DOI 10.1007/s00268-005-0353-x Seybt MW, 2010, LARYNGOSCOPE, V120, P959, DOI 10.1002/lary.20866 Spinelli C, 2008, J PEDIATR SURG, V43, P1259, DOI 10.1016/j.jpedsurg.2008.02.073 Terris DJ, 2008, ORL J OTO-RHINO-LARY, V70, P287, DOI 10.1159/000149830 Terris DJ, 2009, OP TECHN OTOLARYNGOL, V20, P23 Terris DJ, 2008, ARCH OTOLARYNGOL, V134, P81, DOI 10.1001/archoto.2007.22 Terris DJ, 2007, ARCH OTOLARYNGOL, V133, P1254, DOI 10.1001/archotol.133.12.1254 Thompson GB, 2004, WORLD J SURG, V28, P1187, DOI 10.1007/s00268-004-7605-z NR 19 TC 2 Z9 2 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD APR PY 2011 VL 120 IS 4 BP 215 EP 219 PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA 753GO UT WOS:000289760500001 PM 21585149 ER PT J AU Swarts, JD Alper, CM Mandel, EM Villardo, R Doyle, WJ AF Swarts, J. Douglas Alper, Cuneyt M. Mandel, Ellen M. Villardo, Richard Doyle, William J. TI Eustachian Tube Function in Adults Without Middle Ear Disease SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE adult; eustachian tube; function testing ID ONSET OTITIS-MEDIA; HEARING-LOSS; EFFUSION; VENTILATION; TUBOPLASTY; CHILDREN AB Objectives: We sought to develop normative values for 5 eustachian tube function (ETF) test protocols in adults without otitis media (OM). Methods: Twenty adults (19 to 48 years of age) without a recent history of OM (5 had OM in childhood) underwent unilateral myringotomy and were evaluated for ETF by use of the forced response, inflation, deflation, forcible "sniff," and Valsalva test protocols. When possible, these tests were repeated on a second day. Results: Normative values for the parameters of these protocols in adult subjects without a recent history of OM were developed. Between-day data for the forced response test were highly correlated. A percentage of these tests showed eustachian tube "constriction" during swallowing an abnormal condition. The percent reduction in applied pressures for the inflation and deflation tests was high, indicative of good ETF. Few subjects had a positive "sniff" test, whereas most had a positive Valsalva test, and the results for both tests were effort-dependent. Conclusions: Results of ETF tests in adults with and without recent OM have not been published. Normative data are now available for comparison with ETF test results in adults with OM. These protocols will be used to evaluate the efficacy of surgical procedures designed to improve ETF. C1 Univ Pittsburgh, Childrens Hosp Pittsburgh, Med Ctr, Div Pediat Otolaryngol, Pittsburgh, PA 15213 USA. Univ Pittsburgh, Sch Med, Dept Otolaryngol, Pittsburgh, PA USA. RP Swarts, JD (reprint author), 3420 5th Ave,Oakland Med Bldg,Room 118, Pittsburgh, PA 15213 USA. FU National Institutes of Health [P50 DC007667] FX From the Division of Pediatric Otolaryngology, Children's Hospital of Pittsburgh of University of Pittsburgh Medical Center, and the Department of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania. Supported in part by a grant from the National Institutes of Health (P50 DC007667). CR Bluestone CD, 2004, LARYNGOSCOPE, V114, P1, DOI 10.1097/01.mlg.0000148223.45374.ec BYLANDER A, 1981, ACTA OTO-LARYNGOL, V92, P481, DOI 10.3109/00016488109133287 CANTEKIN EI, 1979, ANN OTO RHINOL LARYN, V88, P603 FALK B, 1981, J OTOLARYNGOL, V10, P299 Ferguson MO, 1998, ARCH OTOLARYNGOL, V124, P678 FERNAU JL, 1992, LARYNGOSCOPE, V102, P48 FINKELSTEIN Y, 1988, ANN OTO RHINOL LARYN, V97, P199 FINKELSTEIN Y, 1994, ARCH OTOLARYNGOL, V120, P517 Ho KY, 2008, J OTOLARYNGOL-HEAD N, V37, P362, DOI 10.2310/7070.2008.0071 Hurst DS, 2008, INT J PEDIATR OTORHI, V72, P1215, DOI 10.1016/j.ijporl.2008.04.013 MAGNUSON B, 1983, J OTOLARYNGOL, V12, P187 MCBRIDE TP, 1988, LARYNGOSCOPE, V98, P655 Metson R, 2007, OTOLARYNG HEAD NECK, V136, P422, DOI 10.1016/j.otohns.2006.10.031 MILLS R, 1992, CLIN OTOLARYNGOL, V17, P271, DOI 10.1111/j.1365-2273.1992.tb01841.x Mondain M, 1997, LARYNGOSCOPE, V107, P1414, DOI 10.1097/00005537-199710000-00022 PICORNELLDARDER I, 1978, ELECTROEN CLIN NEURO, V45, P648, DOI 10.1016/0013-4694(78)90165-7 Poe DS, 2007, LARYNGOSCOPE, V117, P231, DOI 10.1097/01.mlg.0000246227.65877.1f Poe DS, 2007, OTOL NEUROTOL, V28, P668 Poe DS, 2000, AM J OTOL, V21, P602 Salvinelli F, 2005, CLIN OTOLARYNGOL, V30, P409, DOI 10.1111/j.1365-2273.2005.01052.x Schneider JM, 2010, MED J AUSTRALIA, V192, P20 Sedlmaier B, 2009, LASER MED SCI, V24, P793, DOI 10.1007/s10103-009-0646-7 Sone M, 2007, ACTA OTO-LARYNGOL, V127, P470, DOI 10.1080/00016480600868406 SWANS JD, 2003, INT J PEDIATR OTORHI, V67, P853 Uzun C, 2005, OTOL NEUROTOL, V26, P59, DOI 10.1097/00129492-200501000-00010 Yung MW, 2001, J LARYNGOL OTOL, V115, P874 NR 26 TC 9 Z9 9 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD APR PY 2011 VL 120 IS 4 BP 220 EP 225 PG 6 WC Otorhinolaryngology SC Otorhinolaryngology GA 753GO UT WOS:000289760500002 PM 21585150 ER PT J AU Lasisi, AO Gureje, O AF Lasisi, Akeem O. Gureje, Oye TI Prevalence of Insomnia and Impact on Quality of Life Among Community Elderly Subjects With Tinnitus SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE community elderly; insomnia; quality of life; tinnitus ID PITUITARY-ADRENAL AXIS; SLEEP DISTURBANCE; WHOQOL-BREF; POPULATION; DEPRESSION; IBADAN AB Objectives: We sought to determine the prevalence of insomnia and its impact on the quality of life (QoL) among community elderly subjects (at least 65 years of age) with subjective tinnitus. Methods: After household selection with multistage stratified area probability sampling, face-to-face interviews were used to obtain self-reports of subjective tinnitus and insomnia, and QoL was assessed with the WHOQoL-Bref instrument. Results: Among 1,302 elderly subjects, there were 183 subjects (109 female and 74 male) with tinnitus. Among those with tinnitus, insomnia was encountered in 95 (51.9%) and was found to be significantly more common among those with tinnitus than among those without (378 of 1,119, or 33.8%; p = 0.002). The insomnia symptoms included difficulty in maintaining sleep in 73.4% of subjects, difficulty in falling asleep in 70.0%, early morning wakefulness in 64.3%, non-restorative sleep in 35.1%, and daytime sleepiness in 34.7%. Univariate analysis revealed difficulty with falling asleep (p = 0.01) and early morning wakefulness (p = 0.05) to be significantly associated with tinnitus among the symptoms. Student's t-test and logistic regression analysis revealed significant deterioration in the total QoL and in the physical, psychological, social, and environmental QoL domains among elderly subjects who had tinnitus with insomnia as compared with those without insomnia. Conclusions: We believe that insomnia is significantly more common among elderly subjects with tinnitus than among those without, and that its presence further depreciates the QoL in these elderly individuals. C1 [Lasisi, Akeem O.] Univ Ibadan, Dept Otorhinolaryngol, Ibadan, Nigeria. [Gureje, Oye] Univ Ibadan, Dept Psychiat, Ibadan, Nigeria. RP Lasisi, AO (reprint author), Univ Ibadan, Dept Otorhinolaryngol, POB 22040, Ibadan, Nigeria. FU Wellcome Trust FX From the Departments of Otorhinolaryngology (Lasisi) and Psychiatry (Gureje), University of Ibadan, Ibadan, Nigeria. The Ibadan Study of Ageing is funded by the Wellcome Trust. The Wellcome Trust was not involved in the collection, analysis, or interpretation of the data presented in this report. CR ALSTER J, 1993, BIOL PSYCHIAT, V34, P84, DOI 10.1016/0006-3223(93)90260-K [Anonymous], 1994, VIT HLTH STAT, V2, P1 Asplund R, 2003, ARCH GERONTOL GERIAT, V37, P139, DOI 10.1016/S0167-4943(03)00028-1 ATTIAS J, 1990, SCAND AUDIOL, V19, P245, DOI 10.3109/01050399009070779 AXELSSON A, 1989, British Journal of Audiology, V23, P53, DOI 10.3109/03005368909077819 Bekibele CO, 2008, OPHTHAL EPIDEMIOL, V15, P250, DOI 10.1080/09286580802336583 Cronlein T, 2007, PROG BRAIN RES, V166, P227, DOI 10.1016/S0079-6123(07)66021-X Drake CL, 2003, DEPRESS ANXIETY, V18, P163, DOI 10.1002/da.10151 Eysel-Gosepath K, 2005, LARYNGO RHINO OTOL, V84, P323, DOI 10.1055/s-2005-861020 Folmer RL, 2000, AM J OTOLARYNG, V21, P287, DOI 10.1053/ajot.2000.9871 Gureje O, 2006, J AM GERIATR SOC, V54, P1784, DOI 10.1111/j.1532-5415.2006.00944.x Hallam RS, 1996, SCAND AUDIOL, V25, P263, DOI 10.3109/01050399609074965 Hatzinger M, 2000, World J Biol Psychiatry, V1, P105, DOI 10.3109/15622970009150573 Hosmer DW, 2000, APPL LOGISTIC REGRES, V2nd JAKES SC, 1985, AUDIOLOGY, V24, P195 Katz DA, 2002, J FAM PRACTICE, V51, P229 Kish L, 1965, SURVEY SAMPLING KLINK ME, 1994, CHEST, V105, P151, DOI 10.1378/chest.105.1.151 Lasisi AO, 2010, T ROY SOC TROP MED H, V104, P518, DOI 10.1016/j.trstmh.2010.03.009 Leger JM, 2002, INT PSYCHOGERIATR, V14, P405 Mahowald ML, 2000, SLEEP MED, V1, P179, DOI 10.1016/S1389-9457(00)00029-0 MEIKLE MB, 1984, OTOLARYNG HEAD NECK, V92, P689 Naumann VJ, 2004, INT PSYCHOGERIATR, V16, P159, DOI 10.1017/S1041610204000109 Sanchez L, 2000, AUDIOLOGY, V39, P333 SCOTT B, 1990, British Journal of Audiology, V24, P51, DOI 10.3109/03005369009077842 StataCorp, 2001, STAT STAT SOFTW VERS Harper A, 1998, PSYCHOL MED, V28, P551 TYLER RS, 1983, J SPEECH HEAR DISORD, V48, P150 Vgontzas AN, 2001, J CLIN ENDOCR METAB, V86, P3787, DOI 10.1210/jc.86.8.3787 Vgontzas Alexandros N, 2002, Sleep Med, V3, P389, DOI 10.1016/S1389-9457(02)00067-9 Watson S, 2002, PSYCHOL MED, V32, P1021, DOI 10.1017/S0033291702005998 NR 31 TC 7 Z9 9 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD APR PY 2011 VL 120 IS 4 BP 226 EP 230 PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA 753GO UT WOS:000289760500003 PM 21585151 ER PT J AU Zuercher, B Tritten, JJ Friedrich, JP Monnier, P AF Zuercher, Barbara Tritten, Jean-Jacques Friedrich, Jean Paul Monnier, Philippe TI Analysis of Functional and Anatomic Success Following Endonasal Dacryocystorhinostomy SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE endonasal dacryocystorhinostomy; endoscopy; functional success ID EXTERNAL DACRYOCYSTORHINOSTOMY; LASER DACRYOCYSTORHINOSTOMY; ENDOSCOPIC DACRYOCYSTORHINOSTOMY; NASOLACRIMAL DUCT; OBSTRUCTION; THERAPY; SYSTEM; UNCIFORMECTOMY; COMPLICATIONS; RADIATION AB Objectives: The aim of this study was to assess the concomitant perioperative procedures, the causes of nasolacrimal duct obstruction, the success rate, and the complications associated with endonasal dacryocystorhinostomy (ENDCR). Methods: In this single-center retrospective study, 98 patients underwent 104 ENDCRs between January 1994 and February 2006. There were 78 patients with 84 nasolacrimal duct obstructions who were included in this study. Results: The overall functional success rate with improvement in symptoms was 94.9% for primary surgery (59 of 84 obstructions) and 63.6% for salvage surgery after failure of primary surgery performed in another hospital (25 of 84 obstructions). The mean follow-up time was 36.8 +/- 17.11 months. Primary surgery showed better results, with a complete success rate of 93.2%, than did salvage surgery, with a success rate of only 68%. Persistent symptoms, despite an open rhinostomy, were found in 1.7% of patients with primary surgery and in 12% of those with salvage surgery. Failure of ENDCR was observed in 3.4% of patients after primary surgery and in 20% after salvage surgery. We encountered only minimal perioperative complications, and these were essentially related to lacrimal intubation. Conclusions: Because of the possibility of treating concomitant sinonasal disorders, the cosmetic advantages, and the excellent results, ENDCR represents the procedure of choice for treating nasolacrimal duct obstructions. The main challenge lies in the exact preoperative assessment, as well as postoperative evaluation in case of failure. C1 [Zuercher, Barbara; Monnier, Philippe] Univ Hosp CHUV, Dept Otorhinolaryngol Head & Neck Surg, Lausanne, Switzerland. [Tritten, Jean-Jacques] Hosp Neuchatel, Dept Ophthalmol, La Chaux de Fonds, Switzerland. [Friedrich, Jean Paul] Hosp Neuchatel, Dept Otorhinolaryngol, La Chaux de Fonds, Switzerland. RP Zuercher, B (reprint author), Univ Bern, Inselspital, Dept Otorhinolaryngol Head & Neck Surg, CH-3010 Bern, Switzerland. CR ADENIS JP, 1987, J FR OPHTALMOL, V10, P323 Arullendran P, 2001, J LARYNGOL OTOL, V115, P1015 Beigi B, 2007, EUR J OPHTHALMOL, V17, P485 Ben Simon GJ, 2005, OPHTHALMOLOGY, V112, P1463, DOI 10.1016/j.ophtha.2005.03.015 Bertelmann E, 2006, GRAEF ARCH CLIN EXP, V244, P677, DOI 10.1007/s00417-005-0139-8 BOLDEA RC, 2004, REV MED SUISSE ROMAN, V124, P265 Burns JA, 2004, OPHTHAL PLAST RECONS, V20, P126, DOI 10.1097/01.IOP.0000117340.41819.81 Caldwell GW, 1893, NY MED J, V57, P581 Cokkeser Y, 2000, OTOLARYNG HEAD NECK, V123, P488, DOI 10.1067/mhn.2000.105470 Dolman PJ, 2003, OPHTHALMOLOGY, V110, P78, DOI 10.1016/S0161-6420(02)01452-5 DUCASSE A, 1993, B SOC OPHTALMOL FR, V93, P35 Fayet B, 2002, OPHTHALMOLOGY, V109, P530, DOI 10.1016/S0161-6420(01)00977-0 Fayet B, 2004, OPHTHALMOLOGY, V111, P837, DOI 10.1016/j.ophtha.2003.08.023 GORDON KB, 1995, INT J RADIAT ONCOL, V31, P1123, DOI 10.1016/0360-3016(95)00062-4 Hartikainen J, 1998, OPHTHALMOLOGY, V105, P1106, DOI 10.1016/S0161-6420(98)96015-8 Herbert HM, 2007, ARCH OPHTHALMOL-CHIC, V125, P1674, DOI 10.1001/archopht.125.12.1674 Ibrahim HA, 2001, OPHTHALMIC SURG LAS, V32, P220 Keerl R, 2004, LARYNGO RHINO OTOL, V83, P40, DOI 10.1055/s-2004-814110 McNeill EJ, 2005, AM J RHINOL, V19, P588 Merkonidis C, 2005, BRIT J OPHTHALMOL, V89, P1589, DOI 10.1136/bjo.2005.072199 Minasian M, 1999, ORBIT, V18, P167, DOI 10.1076/orbi.18.3.167.2710 Moore WMH, 2002, OPHTHALMOLOGY, V109, P1575, DOI 10.1016/S0161-6420(02)01114-4 NAKISSA N, 1983, CANCER, V51, P980, DOI 10.1002/1097-0142(19830315)51:6<980::AID-CNCR2820510603>3.0.CO;2-Y Nussbaumer M, 2004, J LARYNGOL OTOL, V118, P267 O'Donnell BA, 2007, OPHTHAL PLAST RECONS, V23, P173, DOI 10.1097/IOP.0b013e31803e1744 Ozturk S, 2004, OPHTHAL PLAST RECONS, V20, P130, DOI 10.1097/01.IOP.0000115597.92546.D5 Ressiniotis Thomas, 2005, BMC Ophthalmol, V5, P5, DOI 10.1186/1471-2415-5-5 Sadiq SA, 1997, BRIT J OPHTHALMOL, V81, P1089, DOI 10.1136/bjo.81.12.1089 Sadiq SA, 1996, EYE, V10, P43 Sahlin S, 2001, ORBIT, V20, P173, DOI 10.1076/orbi.20.3.173.2622 Sakahara H, 2007, ANN NUCL MED, V21, P525, DOI 10.1007/s12149-007-0056-5 Smirnov G, 2006, AM J RHINOL, V20, P600, DOI 10.2500/ajr.2006.20.2955 Toti A, 1904, CLIN MOD FIRENZE, V10, P385 Tsirbas A, 2003, AM J OPHTHALMOL, V135, P76, DOI 10.1016/S0002-9394(02)01830-5 Tsirbas A, 2005, AM J RHINOL, V19, P322 Tsirbas A, 2004, OPHTHAL PLAST RECONS, V20, P50, DOI 10.1097/01.IOP.0000103006.49679.23 Wormald PJ, 2004, CLIN OTOLARYNGOL, V29, P352, DOI 10.1111/j.1365-2273.2004.00836.x Yung MW, 1998, CLIN OTOLARYNGOL, V23, P152 NR 38 TC 5 Z9 6 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD APR PY 2011 VL 120 IS 4 BP 231 EP 238 PG 8 WC Otorhinolaryngology SC Otorhinolaryngology GA 753GO UT WOS:000289760500004 PM 21585152 ER PT J AU Simpson, CB May, LS Green, JK Eller, RL Jackson, CE AF Simpson, C. Blake May, Linda Seitan Green, Jill K. Eller, Robert L. Jackson, Carlayne E. TI Vibratory Asymmetry in Mobile Vocal Folds: Is It Predictive of Vocal Fold Paresis? SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE electromyography; videostroboscopy; vocal fold paralysis; vocal fold paresis AB Objectives: The purpose of this study was to determine whether the videostroboscopic finding of vibratory asymmetry in mobile vocal folds is a reliable predictor of vocal fold paresis. In addition, the ability of experienced reviewers to predict the distribution (left/right/bilateral) of the paresis was investigated. Methods: This is a retrospective chart review of all patients who presented to our clinic during a 3-year period with symptoms suggestive of glottal insufficiency (vocal fatigue or reduced vocal projection) accompanied by the videostroboscopic findings of bilateral normal vocal fold mobility and vibratory asymmetry. Twenty-three of these patients underwent diagnostic laryngeal electromyography of the thyroarytenoid and cricothyroid muscles to determine the presence of vocal fold paresis. Results: Nineteen of the 23 patients (82.6%) were found to have electrophysiological evidence of vocal fold paresis, either unilaterally or bilaterally, when videostroboscopic asymmetry was present in mobile vocal folds. However, the three expert reviewers' ability to predict the distribution (left/right/bilateral) of the paresis was poor (26.3%, 36.8%, and 36.8%, respectively). Conclusions: The videostroboscopic finding of vibratory asymmetry in mobile vocal folds is a reliable predictor of vocal fold paresis in most cases. However, the ability of expert reviewers to determine the distribution (left/right/bilateral) of the paresis using videostroboscopic findings is poor. This study highlights the value of laryngeal electromyography in arriving at a correct diagnosis in this clinical situation. C1 [Simpson, C. Blake] Univ Texas Hlth Sci Ctr San Antonio, Dept Otolaryngol Head & Neck Surg, Med Arts & Res Ctr, San Antonio, TX 78229 USA. [Jackson, Carlayne E.] Univ Texas Hlth Sci Ctr San Antonio, Dept Neurol, San Antonio, TX 78229 USA. [Eller, Robert L.] Lackland AFB, Dept Otolaryngol Head & Neck Surg, Wilford Hall Med Ctr, San Antonio, TX USA. RP Simpson, CB (reprint author), Univ Texas Hlth Sci Ctr San Antonio, Dept Otolaryngol Head & Neck Surg, Med Arts & Res Ctr, 8300 Floyd Curl Dr, San Antonio, TX 78229 USA. CR Altman KW, 2005, ARCH OTOLARYNGOL, V131, P356, DOI 10.1001/archotol.131.4.356 Heman-Ackah Yolanda D, 2006, J Voice, V20, P269, DOI 10.1016/j.jvoice.2005.03.010 Koufman JA, 2000, OTOLARYNG HEAD NECK, V122, P537, DOI 10.1016/S0194-5998(00)70097-0 Koufman JA, 1995, DIAGNOSIS TREATMENT, P122 Merati AL, 2006, AM J OTOLARYNG, V27, P106, DOI 10.1016/j.amjoto.2005.07.020 Rubin AD, 2005, J VOICE, V19, P679, DOI 10.1016/j.jvoice.2004.11.001 Simpson CB, 2009, J VOICE, V23, P396, DOI 10.1016/j.jvoice.2007.10.011 Sulica Lucian, 2007, Curr Opin Otolaryngol Head Neck Surg, V15, P159, DOI 10.1097/MOO.0b013e32814b0875 NR 8 TC 11 Z9 11 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD APR PY 2011 VL 120 IS 4 BP 239 EP 242 PG 4 WC Otorhinolaryngology SC Otorhinolaryngology GA 753GO UT WOS:000289760500005 PM 21585153 ER PT J AU de Heer, AMR Schraders, M Oostrik, J Hoefsloot, L Huygen, PLM Cremers, CWRJ AF de Heer, Anne-Martine R. Schraders, Margit Oostrik, Jaap Hoefsloot, Lies Huygen, Patrick L. M. Cremers, Cor W. R. J. TI Audioprofile-Directed Successful Mutation Analysis in a DFNA2/KCNQ4 (p.Leu274His) Family SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE age-related typical audiogram; AudioGene; audioprofile; DFNA2; genetic hearing loss; KCNQ4 ID SENSORINEURAL HEARING-LOSS; KCNQ4 GENE; NONSYNDROMIC DEAFNESS; HAIR-CELLS; DOMINANT DEAFNESS; PORE-REGION; HOT-SPOT; IMPAIRMENT; DFNA2; EXPRESSION AB Objectives: We undertook to show that in a family with nonsyndromic autosomal dominant sensorineural hearing loss, genetic analysis can be successful when there is a match with a specific DFNA audioprofile. We also provide an update of relevant DFNA2/KCNQ4 audioprofiles and report the results of automatic audioprofile analysts using the Internet program AudioGene. Methods: Audiometric data and blood samples were obtained from the family W08-0384. Based on the audiograms of the affected participants, mutation analysis of KCNQ4 was started. Original audiometric threshold data were collected for all identified KCNQ4-related DFNA2 families. The Internet computer program AudioGene, recently developed for automatic audioprofile analysis, was accessed. Results: The family's audioprofile and the program AudioGene predicted the DFNA2/KCNQ4 locus. Mutation analysis of KCNQ4 revealed a c.821T > A (p.Leu274His) mutation of the KCNQ4 gene. This mutation has been previously identified in a Dutch family. Genetic analysis revealed a common haplotype in these two families over a region including the KCNQ4 gene. Conclusions: Familiarity with the audioprofiles of DFNA traits may lead to successful mutation analysis of the gene involved, even in a small family in which genetic linkage analysis is not an option. Alternatively, the specially developed program AudioGene can be accessed on the Internet to perform automatic audioprofile analysis of a family's (audiological) phenotype. C1 [de Heer, Anne-Martine R.; Schraders, Margit; Oostrik, Jaap; Huygen, Patrick L. M.; Cremers, Cor W. R. J.] Radboud Univ Nijmegen, Med Ctr, Dept Otorhinolaryngol, Clin Neurosci Donders Ctr Brain Cognit & Behav, NL-6500 HB Nijmegen, Netherlands. [Hoefsloot, Lies] Radboud Univ Nijmegen, Med Ctr, Dept Human Genet, Clin Neurosci Donders Ctr Brain Cognit & Behav, NL-6500 HB Nijmegen, Netherlands. RP de Heer, AMR (reprint author), Radboud Univ Nijmegen, Med Ctr, Dept Otorhinolaryngol, Clin Neurosci Donders Ctr Brain Cognit & Behav, POB 9101, NL-6500 HB Nijmegen, Netherlands. FU Heinsius Houbolt Foundation; RNID; Fonds NutsOhra FX From the Departments of Otorhinolaryngology (de Heer, Schraders, Oostrik, Huygen, Cremers) and Human Genetics (Hoefsloot), Radboud University Nijmegen Medical Center, Clinical Neuroscience Donders Center for Brain, Cognition and Behavior, Nijmegen, the Netherlands. This work was supported by the Heinsius Houbolt Foundation, the RNID, and Fonds NutsOhra. CR Akita J, 2001, J HUM GENET, V46, P355, DOI 10.1007/s100380170053 Beisel KW, 2005, J NEUROSCI, V25, P9285, DOI 10.1523/JNEUROSCI.2110-05.2005 Beisel Kirk W., 2000, Molecular Brain Research, V82, P137, DOI 10.1016/S0169-328X(00)00204-7 Bom SJH, 2001, ARCH OTOLARYNGOL, V127, P1045 Coucke PJ, 1999, HUM MOL GENET, V8, P1321, DOI 10.1093/hmg/8.7.1321 CREMERS CWR, 2002, GENETIC HEARING IMPA Cremers CWRJ, 2000, J LARYNGOL OTOL, V114, P6 De Leenheer Els M. R., 2002, VVolume 61, P41 De Leenheer EMR, 2002, ANN OTO RHINOL LARYN, V111, P267 Ensink RJH, 2000, EUR ARCH OTO-RHINO-L, V257, P62, DOI 10.1007/PL00007511 Hildebrand MS, 2008, GENET MED, V10, P297, DOI 10.1097/GIM.0b013e318187e106 Hildebrand MS, 2009, LARYNGOSCOPE, V119, P2211, DOI 10.1002/lary.20664 Huygen PL, 2007, GENES HEARING DEAFNE, P185 Huygen PL, 2003, AUDIOL MED, V1, P37 Kamada F, 2006, J HUM GENET, V51, P455, DOI 10.1007/s10038-006-0384-7 Kubisch C, 1999, CELL, V96, P437, DOI 10.1016/S0092-8674(00)80556-5 Kunst H, 1998, LARYNGOSCOPE, V108, P74, DOI 10.1097/00005537-199801000-00014 Marres H, 1997, ARCH OTOLARYNGOL, V123, P573 Mencia A, 2008, HUM GENET, V123, P41, DOI 10.1007/s00439-007-0447-7 Petit C, 1996, NAT GENET, V14, P385, DOI 10.1038/ng1296-385 Ruel J, 2008, AM J HUM GENET, V83, P278, DOI 10.1016/j.ajhg.2008.07.008 Smith RJH, 2003, ARCH OTOLARYNGOL, V129, P405, DOI 10.1001/archotol.129.4.405 Su CC, 2007, AUDIOL NEURO-OTOL, V12, P20, DOI 10.1159/000096154 Talebizadeh Z, 1999, HUM MUTAT, V14, P493, DOI 10.1002/(SICI)1098-1004(199912)14:6<493::AID-HUMU8>3.0.CO;2-P Topsakal V, 2005, OTOL NEUROTOL, V26, P52, DOI 10.1097/00129492-200501000-00009 Van Camp G, HEREDITARY HEARING L VanCamp G, 1997, AM J HUM GENET, V60, P758 Van Camp G, 2002, HUM MUTAT, V20, P15, DOI 10.1002/humu.10096 Van Hauwe P, 2000, AM J MED GENET, V93, P184, DOI 10.1002/1096-8628(20000731)93:3<184::AID-AJMG4>3.0.CO;2-5 NR 29 TC 5 Z9 5 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD APR PY 2011 VL 120 IS 4 BP 243 EP 248 PG 6 WC Otorhinolaryngology SC Otorhinolaryngology GA 753GO UT WOS:000289760500006 PM 21585154 ER PT J AU Salami, A Mora, R Crippa, B Gentile, R Dellepiane, M Guastini, L AF Salami, Angelo Mora, Renzo Crippa, Barbara Gentile, Raffaella Dellepiane, Massimo Guastini, Luca TI Potential Nerve Damage Following Contact With a Piezoelectric Device SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE bone surgery; facial nerve; histologic examination; piezoelectric device ID FACIAL-NERVE; BONE SURGERY; EXPERIENCE; PIEZOSURGERY(R); DECOMPRESSION AB Objectives: The aim of the study was to assess the extent of the potential nerve damage following prolonged contact with a piezoelectric device. Methods: The study was conducted with 30 patients; all of the patients had cervical metastatic lymph nodes at levels II, III, and IV (N2b) and a negative evaluation for metastatic disease (MO). The patients underwent radical neck dissection. After its skeletonization, the spinal nerve was exposed directly to ultrasonic activation with a piezoelectric device for various times (5, 10, and 20 seconds) and with different inserts (OP3 insert and OT7 insert). The axonal damage was graded from 0 to 3 as follows: 0, no damage; 1, minor axonal damage; 2, severe axonal damage but not covering the entirety of the nerve fascicles; 3, severe axonal damage covering the entirety of the nerve fascicles. Results: Histologic examination showed no evidence of damage to the perineurium and axons after 5 and 10 seconds of exposure to ultrasonic activation with each insert. Conclusions: Our histologic data highlight the selective action of the piezoelectric device, which reduces the risk of accidental nerve damage in otolaryngological bone surgery. C1 [Salami, Angelo; Mora, Renzo; Crippa, Barbara; Dellepiane, Massimo; Guastini, Luca] Univ Genoa, Dept Otorhinolaryngol, Genoa, Italy. [Gentile, Raffaella] San Martino Hosp, Dept Pathol, Genoa, Italy. RP Mora, R (reprint author), Via Mille 11-9, I-16147 Genoa, Italy. CR Anand VK, 1997, LARYNGOSCOPE, V107, P1393, DOI 10.1097/00005537-199710000-00019 Gleizal A, 2007, CHILD NERV SYST, V23, P509, DOI 10.1007/s00381-006-0250-0 Bolger WE, 2009, ANN OTO RHINOL LARYN, V118, P621 Dellepiane M, 2008, ENT-EAR NOSE THROAT, V87, P212 Eaton DA, 2007, AM J OTOLARYNG, V28, P37, DOI 10.1016/j.amjoto.2006.06.009 Lenhardt Martin L, 2003, Int Tinnitus J, V9, P69 Salami A, 2008, ACTA OTO-LARYNGOL, V128, P530, DOI 10.1080/00016480701635175 Salami A, 2009, OTOLARYNG HEAD NECK, V140, P412, DOI 10.1016/j.otohns.2008.11.013 Salami A, 2007, MED SCI MONITOR, V13, pPI25 Salami A, 2009, OTOLARYNG HEAD NECK, V140, P264, DOI 10.1016/j.otohns.2008.11.019 Salami A, 2008, MED SCI MONITOR, V14, pPI1 Salami A, 2010, AM J OTOLARYNG, V31, P150, DOI 10.1016/j.amjoto.2008.12.001 Samy RN, 2007, LARYNGOSCOPE, V117, P872, DOI 10.1097/MLG.0b013e318033f984 Schaeren S, 2008, J ORAL MAXIL SURG, V66, P593, DOI 10.1016/j.joms.2007.03.025 Vercellotti T, 2004, Minerva Stomatol, V53, P207 Vercellotti T, 2007, ACTA OTO-LARYNGOL, V127, P932, DOI 10.1080/00016480601110154 NR 16 TC 1 Z9 1 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD APR PY 2011 VL 120 IS 4 BP 249 EP 254 PG 6 WC Otorhinolaryngology SC Otorhinolaryngology GA 753GO UT WOS:000289760500007 PM 21585155 ER PT J AU Baik, FM Nguyen, L Doherty, JK Harris, JP Mafee, MF Nguyen, QT AF Baik, Fred M. Nguyen, Linda Doherty, Joni K. Harris, Jeffrey P. Mafee, Mahmood F. Nguyen, Quyen T. TI Comparative Case Series of Exostoses and Osteomas of the Internal Auditory Canal SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE disequilibrium; exostosis; internal auditory canal; osteoma; vertigo; vestibulocochlear nerve AB Exostoses and osteomas are benign bony lesions of the auditory canal. Although common in the external auditory canal, they are rare and difficult to distinguish in the internal auditory canal (IAC). In this literature review and case presentation, we define radiologic and histologic criteria to differentiate exostoses from osteomas of the IAC. Two patients with exostoses and I patient with an osteoma of the IAC are described here. Patient I presented with disabling vertigo and was found to have bilateral exostoses with nerve impingement on the right. After removal of the right-sided exostoses via retrosigmoid craniotomy, the patient had complete resolution of her symptoms over I year. Patient 2 presented with bilateral pulsatile tinnitus and vertigo and was found to have bilateral IAC exostoses. Patient 3 presented with hearing loss and tinnitus, and a unilateral LAC osteoma was ultimately discovered. Because of the mild nature of their symptoms, patients 2 and 3 were managed without surgery. We show that IAC osteomas can be differentiated from exostoses by radiographic evidence of bone marrow in high-resolution computed tomography scans, or by the presence of fibrovascular channels on histologic analysis. Management of these rare entities is customized on the basis of patient symptoms. C1 [Baik, Fred M.; Nguyen, Linda; Doherty, Joni K.; Harris, Jeffrey P.; Nguyen, Quyen T.] Univ Calif San Diego, Dept Surg, Div Otolaryngol Head & Neck Surg, La Jolla, CA 92093 USA. [Mafee, Mahmood F.] Univ Calif San Diego, Dept Radiol, La Jolla, CA 92093 USA. RP Nguyen, QT (reprint author), 9500 Gilman Dr 0647,CMM W 330, La Jolla, CA 92093 USA. FU NIH FX From the Division of Otolaryngology-Head and Neck Surgery, Department of Surgery (Baik, L. Nguyen, Doherty, Harris, Q. T. Nguyen), and the Department of Radiology (Mafee), University of California, San Diego, La Jolla, California. Supported by NIH T32 Training Grants to F. M. Baik and L. Nguyen. CR BEALE DJ, 1987, CLIN RADIOL, V38, P67, DOI 10.1016/S0009-9260(87)80411-7 CLERICO DM, 1994, ANN OTO RHINOL LARYN, V103, P619 Coakley DJ, 1996, J LARYNGOL OTOL, V110, P158 Davis TC, 2000, AM J OTOL, V21, P852 DOAN HT, 1988, J LARYNGOL OTOL, V102, P173, DOI 10.1017/S0022215100104438 ESTREM SA, 1993, OTOLARYNG HEAD NECK, V108, P293 Gerganov Venelin M, 2008, Neurosurgery, V62, pE528, DOI 10.1227/01.neu.0000316023.81786.b6 GRAHAM MD, 1979, ANN OTO RHINOL LARYN, V88, P566 GRIFFEY L E, 1960, Ann Otol Rhinol Laryngol, V69, P178 HANSON W, 1995, ANN OTO RHINOL LARYN, V104, P823 KEMINK JL, 1982, J OTOLARYNGOL, V11, P101 Nager GT, 1982, ANN OTOL RHINOL S92, V91, P1 PHELPS PD, 1975, BRIT J RADIOL, V48, P973 RAMSAY HAW, 1994, ARCH OTOLARYNGOL, V120, P207 SINGH V, 1992, J LARYNGOL OTOL, V106, P905, DOI 10.1017/S0022215100121243 Vrabec JT, 2000, ARCH OTOLARYNGOL, V126, P895 Wright A, 1996, BRIT J NEUROSURG, V10, P503, DOI 10.1080/02688699647177 NR 17 TC 2 Z9 2 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD APR PY 2011 VL 120 IS 4 BP 255 EP 260 PG 6 WC Otorhinolaryngology SC Otorhinolaryngology GA 753GO UT WOS:000289760500008 PM 21585156 ER PT J AU Magliulo, G Colicchio, MG Ciniglio, M AF Magliulo, Giuseppe Colicchio, Maria Giovanna Ciniglio, Mario TI Facial Nerve Dehiscence and Cholesteatoma SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE cholesteatoma; dehiscence; facial nerve; mastoidectomy; surgery ID CHRONIC OTITIS-MEDIA; CANAL DEHISCENCE; MIDDLE-EAR; SURGERY; BONE; MASTOIDECTOMY; PARALYSIS AB Objectives: We evaluated the incidence of facial nerve dehiscence in a group of patients with cholesteatoma who underwent otologic surgery. Methods: We performed a retrospective study in a tertiary referral hospital of 336 patients (298 adults, 38 children) with cholesteatoma who underwent surgery in the years 1998 to 2008. Using intraoperative findings, we assessed the incidence of facial nerve dehiscence in a group of patients with cholesteatoma. We quantified, in adult versus pediatric patients and in primary versus revision surgeries, the occurrence of facial nerve dehiscence, the predisposed anatomic sites, and the coexistence of semicircular canal fistula. In a selected group of 67 patients, preoperative 0.55-mm collimation computed tomography (CT) scans were compared with the intraoperative findings. Results: The frequency of facial nerve dehiscence in this group of patients was 27.1%. The dehiscence was detected in 29.5% of the adults, but in only 7.8% of the patients 16 years and younger. Dehiscence was present in 42.3% of the patients who underwent revision surgery. The most common site of dehiscence (92.3%) was the tympanic segment. The sensitivity and specificity of CT were 69% and 87%, respectively. Conclusions: Dehiscence of the facial nerve was found in 27.1% of patients with cholesteatoma, with a significant difference between patients of pediatric and adult ages. A dehiscent facial nerve was more commonly seen during revision surgery and more frequent in patients older than 16 years. The site of dehiscence most frequently involved by cholesteatoma was the tympanic segment. The presence of a semicircular canal fistula increases the risk of facial nerve dehiscence. Finally, the results of preoperative CT scans are encouraging for the use of CT in predicting facial nerve dehiscence. C1 [Magliulo, Giuseppe; Colicchio, Maria Giovanna; Ciniglio, Mario] Univ Roma La Sapienza, G Ferreri Dept Otorhinolaryngol Audiol & Phoniatr, I-00165 Rome, Italy. RP Magliulo, G (reprint author), Univ Roma La Sapienza, G Ferreri Dept Otorhinolaryngol Audiol & Phoniatr, Via Gregorio VII 80, I-00165 Rome, Italy. CR ARTICO M, 2008, MOL MED REP, V1, P345 BAXTER A, 1971, Journal of Laryngology and Otology, V85, P587, DOI 10.1017/S0022215100073849 CHOLE RA, 1993, ANN OTO RHINOL LARYN, V102, P616 Choung YH, 2006, OTOLARYNG HEAD NECK, V135, P872, DOI 10.1016/j.otohns.2006.04.008 Daniels RL, 2001, OTOL NEUROTOL, V22, P603, DOI 10.1097/00129492-200109000-00007 DERLACKI E L, 1957, Laryngoscope, V67, P420 Di Martino E, 2005, EUR ARCH OTO-RHINO-L, V262, P120, DOI 10.1007/s00405-004-0867-0 Fuse T, 1996, J COMPUT ASSIST TOMO, V20, P221, DOI 10.1097/00004728-199603000-00009 Gerami H, 2009, SAUDI MED J, V30, P104 GREEN JD, 1994, LARYNGOSCOPE, V104, P922 Harvey SA, 1999, OTOLARYNG HEAD NECK, V121, P18, DOI 10.1016/S0194-5998(99)70116-6 KANEKO Y, 1980, LARYNGOSCOPE, V90, P1865, DOI 10.1288/00005537-198011000-00015 Li DQ, 1996, ANN OTO RHINOL LARYN, V105, P467 Lin JC, 2004, OTOLARYNG HEAD NECK, V131, P452, DOI 10.1016/j.otohns.2004.02.054 Moody MW, 2007, OTOL NEUROTOL, V28, P400, DOI 10.1097/01.mao.0000247824.90774.22 MOREANO EH, 1994, LARYNGOSCOPE, V104, P309 MORIYAMA H, 1987, LARYNGOSCOPE, V97, P854 Nilssen ELK, 1997, J LARYNGOL OTOL, V111, P113 ORISEK BS, 1987, ARCH OTOLARYNGOL, V113, P386 Ozbek C, 2009, EUR ARCH OTO-RHINO-L, V266, P357, DOI 10.1007/s00405-008-0748-z Selesnick SH, 2001, OTOL NEUROTOL, V22, P129, DOI 10.1097/00129492-200103000-00002 SHEEHY JL, 1977, ANN OTO RHINOL LARYN, V86, P451 TAKAHASHI H, 1992, ANN OTO RHINOL LARYN, V101, P925 Tange RA, 1997, ORL J OTO-RHINO-LARY, V59, P277 WIET RJ, 1982, OTOLARYNG CLIN N AM, V15, P773 Yetiser S, 2002, OTOL NEUROTOL, V23, P580, DOI 10.1097/00129492-200207000-00030 Zhang Xiuqiang, 2004, Lin Chuang Er Bi Yan Hou Ke Za Zhi, V18, P396 NR 27 TC 10 Z9 10 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD APR PY 2011 VL 120 IS 4 BP 261 EP 267 PG 7 WC Otorhinolaryngology SC Otorhinolaryngology GA 753GO UT WOS:000289760500009 PM 21585157 ER PT J AU Kim, JK Lee, JH Lee, SH Hong, SC Cho, JH AF Kim, Jin Kook Lee, Ji Hye Lee, Seung-Hoon Hong, Seok-Chan Cho, Jae Hoon TI School Performance and Behavior of Korean Elementary School Students With Sleep-Disordered Breathing SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE behavioral disturbance; child; Korea; school performance; sleep-disordered breathing ID COGNITIVE DYSFUNCTION; ACADEMIC-PERFORMANCE; INTERMITTENT HYPOXIA; AGED CHILDREN; APNEA; COMMUNITY; SYMPTOMS AB Objectives: It is known that children with sleep-disordered breathing (SDB) often have accompanying growth retardation and learning and behavior disabilities. However, these results are based mainly on studies of children from European and North American countries. The objective of this study was to investigate the school performance and behavior of Korean children with SDB. Methods: We enrolled 302 third-grade elementary students from an elementary school in Seoul. A survey was conducted, using information from the children's parents for the diagnosis of SDB. The children's height, weight, midterm examination scores, and behavioral disturbances were analyzed. Results: Overall, 299 parents returned the survey. Of the 299 students, 29 (9.7%) were considered to have SDB. They showed no difference from the control in terms of body mass index. The mean examination score was higher in the control group than in the SDB group. However, there was a statistical difference only in social science. The prevalences of students who were inattentive (58.6% versus 23.7%) and lacking in self-control (44.8% versus 14.1%) were significantly higher among students with SDB. Conclusions: SDB is not closely associated with poor school performance among Korean elementary students. However, behavioral disturbance is more frequent among the students with SDB than in those without. C1 [Kim, Jin Kook; Hong, Seok-Chan; Cho, Jae Hoon] Konkuk Univ, Coll Med, Dept Otorhinolaryngol Head & Neck Surg, Seoul 143729, South Korea. [Lee, Ji Hye] Seoul Natl Univ, Grad Sch, Dept Social Studies Educ, Seoul, South Korea. [Lee, Seung-Hoon] Korea Univ, Coll Med, Dept Otorhinolaryngol Head & Neck Surg, Seoul 136705, South Korea. RP Cho, JH (reprint author), Konkuk Univ, Coll Med, Dept Otorhinolaryngol Head & Neck Surg, 4-12 Hwayang Dong, Seoul 143729, South Korea. FU Konkuk University Medical Center [2009] FX From the Department of Otorhinolaryngology-Head and Neck Surgery, College of Medicine, Konkuk University (Kim, Hong, Cho), the Department of Social Studies Education, Graduate School, Seoul National University (J. H. Lee), and the Department of Otorhinolaryngology-Head and Neck Surgery, College of Medicine, Korea University (S.-H. Lee), Seoul, Korea. This work was supported by Konkuk University Medical Center Research Grant 2009. CR Archbold Kristen Hedger, 2004, Biol Res Nurs, V5, P168, DOI 10.1177/1099800403260261 Arman AR, 2005, CHILD CARE HLTH DEV, V31, P707, DOI 10.1111/j.1365-2214.2005.00561.x Bixler EO, 2009, SLEEP, V32, pA66 Carvalho LBC, 2005, J CHILD NEUROL, V20, P400 Castronovo V, 2003, J PEDIATR-US, V142, P377, DOI 10.1067/mpd.2003.118 Chervin RD, 2000, SLEEP MED, V1, P21, DOI 10.1016/S1389-9457(99)00009-X Gottlieb DJ, 2004, J PEDIATR-US, V145, P458, DOI 10.1016/j.jpeds.2004.05.039 Gozal D, 2008, SLEEP MED, V9, P254, DOI 10.1016/j.sleep.2007.04.013 Gozal D, 1998, PEDIATRICS, V102, P616, DOI 10.1542/peds.102.3.616 Gozal D, 2007, AM J RESP CRIT CARE, V176, P188, DOI 10.1164/rccm.200610-1519OC Karpinski AC, 2008, SLEEP MED, V9, P418, DOI 10.1016/j.sleep.2007.06.004 Mitchell Ron B, 2008, Mo Med, V105, P267 Mitchell RB, 2006, LARYNGOSCOPE, V116, P956, DOI 10.1097/01.MLG.0000216413.22408.FD Owens JA, 2009, PEDIATR PULM, V44, P417, DOI 10.1002/ppul.20981 Pang KP, 2004, J LARYNGOL OTOL, V118, P275 Perez-Chada D, 2007, SLEEP, V30, P1698 Row BW, 2003, AM J RESP CRIT CARE, V167, P1548, DOI 10.1164/rccm.200209-1050OC Schechter MS, 2002, PEDIATRICS, V109, DOI 10.1542/peds.109.4.e69 Spicuzza L, 2009, SLEEP MED REV, V13, P111, DOI 10.1016/j.smrv.2008.07.001 Urschitz MS, 2003, AM J RESP CRIT CARE, V168, P464, DOI 10.1164/rccm.200212-1397OC NR 20 TC 5 Z9 5 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD APR PY 2011 VL 120 IS 4 BP 268 EP 272 PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA 753GO UT WOS:000289760500010 PM 21585158 ER PT J AU de Corgnol, AC Guerout, N Duclos, C Verin, E Marie, JP AF de Corgnol, Anne-Christine Guerout, Nicolas Duclos, Celia Verin, Eric Marie, Jean-Paul TI Olfactory Ensheathing Cells in a Rat Model of Laryngeal Reinnervation SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE larynx; olfactory ensheathing cell; peripheral nerve regeneration; reinnervation; synkinesis; vocal fold paralysis ID SPINAL-CORD; IN-VITRO; NEUROTROPHIC FACTORS; NEURON REGENERATION; SENSORY NEURONS; PHRENIC-NERVE; BULB; AXONS; NEUROGENESIS; MUCOSA AB Objectives: Olfactory ensheathing cells have been used successfully for recovery of nervous system lesions. The aim of our study was to determine whether olfactory ensheathing cells from the olfactory bulb or olfactory mucosa were able to improve functional recovery in a laryngeal reinnervation animal model. Methods: Fifty-nine rats were divided into 6 groups. A group without nerve section (group 1; n = 10) and a group without anastomosis (group 2; n = 11) served as controls. Right vagus nerve section and immediate anastomosis (nonselective reinnervation) was performed in 4 other groups, as follows, in group 3 (n = 10), there was selective reinnervation without any addition of substance; groups 4 (n = 10), 5 (n = 10), and 6 (n = 8) received, on the section and anastomosis site, and at the same time, cultivated olfactory bulb, cultivated olfactory mucosa, and noncultivated olfactory mucosa from inbred rats, respectively. Three months later, videolaryngoscopy with vocal fold movement measurements, electromyography, and histologic examination were performed. Results: The best right vocal fold angular movement (3.05 degrees +/- 1.14 degrees) was observed in group 5 with cultivated olfactory mucosa, versus group 3 (-0.28 degrees +/- 1.51 degrees; p = 0.06). The relative angular vocal fold movement was better in group 5 (p = 0.05). The mobility score was 0.6 +/- 0.27 for group 3 and 1.4 +/- 0.31 for group 5 (p = 0.07). Less synkinesis was observed in the reinnervated groups with cell addition, particularly with noncultivated olfactory mucosa (group 6; p = 0.05). Conclusions: Olfactory ensheathing cells obtained from olfactory mucosa cultures seem to improve functional laryngeal reinnervation in a rat model of nonselective vagus nerve section and anastomosis. C1 [de Corgnol, Anne-Christine; Marie, Jean-Paul] Rouen Univ Hosp, Dept Otorhinolaryngol Head & Neck Surg, F-76031 Rouen, France. [de Corgnol, Anne-Christine; Guerout, Nicolas; Duclos, Celia; Verin, Eric; Marie, Jean-Paul] Univ Rouen, Sch Med, EA GRHV 3830, Res Grp Resp Handicap,Expt Surg Lab, Rouen, France. RP Marie, JP (reprint author), Rouen Univ Hosp, Dept Otorhinolaryngol Head & Neck Surg, 1 Rue Germont, F-76031 Rouen, France. FU ADIR (Aide a Domicile aux Insuffisants Respiratoires [Home Help for Respiratory Failure]), Rouen, France FX From the Experimental Surgery Laboratory, EA 3830 GRHV (Groupe de Recherche sur le Handicap Ventilatoire [Research Group on Respiratory Handicap]), School of Medicine, University of Rouen (all authors), and the Department of Otorhinolaryngology-Head and Neck Surgery, Rouen University Hospital (de Corgnol, Marie), Rouen, France. Supported by ADIR (Aide a Domicile aux Insuffisants Respiratoires [Home Help for Respiratory Failure]), Rouen, France. CR Boruch AV, 2001, GLIA, V33, P225, DOI 10.1002/1098-1136(200103)33:3<225::AID-GLIA1021>3.3.CO;2-P Boyd JG, 2005, FASEB J, V19, P694, DOI 10.1096/fj.04-2833rev Boyd JG, 2003, MOL NEUROBIOL, V27, P277, DOI 10.1385/MN:27:3:277 CALOF AL, 1989, NEURON, V3, P115, DOI 10.1016/0896-6273(89)90120-7 Choi D, 2005, NEUROSURGERY, V56, P1093, DOI 10.1227/01.NEU.0000158201.30322.2C Chung RS, 2004, CELL MOL LIFE SCI, V61, P1238, DOI 10.1007/s00018-004-4026-y DEVON R, 1992, BRAIN RES, V589, P175 Dombrowski MA, 2006, BRAIN RES, V1125, P1, DOI 10.1016/j.brainres.2006.09.089 FLINT PW, 1991, ANN OTO RHINOL LARYN, V100, P797 Franceschini IA, 1996, DEV BIOL, V176, P149 Franklin Robin J M, 2003, Anat Rec B New Anat, V271, P71, DOI 10.1002/ar.b.10013 Franklin RJM, 2000, NEURON, V28, P15, DOI 10.1016/S0896-6273(00)00080-5 GRAZIADEI GAM, 1979, J NEUROCYTOL, V8, P197 GRAZIADEI PPC, 1979, J NEUROCYTOL, V8, P1, DOI 10.1007/BF01206454 GUEROUT N, MUSCLE NERV IN PRESS Guerout N, 2010, GLIA, V58, P1570, DOI 10.1002/glia.21030 Guntinas-Lichius O, 2001, EXP NEUROL, V172, P70, DOI 10.1006/exnr.2001.7774 GUNTINASLICHIUS W, 2002, J NEUROSCI, V22, P7121 Inagi K, 1997, ANN OTO RHINOL LARYN, V106, P1012 Jani HR, 2004, GLIA, V47, P130, DOI 10.1002/glia.20038 Lakatos A, 2000, GLIA, V32, P214, DOI 10.1002/1098-1136(200012)32:3<214::AID-GLIA20>3.0.CO;2-7 Li Y, 2008, NEUROSCI LETT, V440, P251, DOI 10.1016/j.neulet.2008.05.085 Li Y, 1998, J NEUROSCI, V18, P10514 Li Y, 2003, J NEUROSCI, V23, P7783 Lima C, 2006, J SPINAL CORD MED, V29, P191 Lipson AC, 2003, EXP NEUROL, V180, P167, DOI 10.1016/S0014-4486(02)00058-4 Marie JP, 1999, ANN OTO RHINOL LARYN, V108, P1004 Marie JP, 1999, ANN OTO RHINOL LARYN, V108, P516 Markus A, 2002, CURR OPIN NEUROBIOL, V12, P523, DOI 10.1016/S0959-4388(02)00372-0 Moreno-Flores M. Teresa, 2002, Journal of Biomedicine and Biotechnology, V2, P37, DOI 10.1155/S1110724302000372 Radtke C, 2009, BRAIN RES, V1254, P10, DOI 10.1016/j.brainres.2008.11.036 RAMONCUETO A, 1992, NEUROSCIENCE, V47, P213, DOI 10.1016/0306-4522(92)90134-N Ramon-Cueto A, 1998, BRAIN RES BULL, V46, P175, DOI 10.1016/S0361-9230(97)00463-2 Richter MW, 2005, J NEUROSCI, V25, P10700, DOI 10.1523/JNEUROSCI.3632-05.2005 SHAWE GDH, 1955, BRIT J SURG, V42, P474, DOI 10.1002/bjs.18004217505 Verdu E, 1999, NEUROREPORT, V10, P1097, DOI 10.1097/00001756-199904060-00035 Wewetzer K, 2001, NEUROSCI LETT, V306, P165, DOI 10.1016/S0304-3940(01)01891-2 Woodhall E, 2001, MOL BRAIN RES, V88, P203, DOI 10.1016/S0169-328X(01)00044-4 NR 38 TC 5 Z9 5 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD APR PY 2011 VL 120 IS 4 BP 273 EP 280 PG 8 WC Otorhinolaryngology SC Otorhinolaryngology GA 753GO UT WOS:000289760500011 PM 21585159 ER PT J AU Guyot, JP Sigrist, A Pelizzone, M Kos, MI AF Guyot, Jean-Philippe Sigrist, Alain Pelizzone, Marco Kos, Maria Izabel TI Adaptation to Steady-State Electrical Stimulation of the Vestibular System in Humans SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE imbalance; prosthesis; rehabilitation; vestibular implant ID PAROXYSMAL POSITIONAL VERTIGO; POSTERIOR AMPULLARY NERVE; EYE-MOVEMENTS; NEURONS; PROSTHESIS AB Objectives: Efforts are being made toward the development of a vestibular implant. If such a device is to mimic the physiology of the vestibular system, it must first be capable of restoring a baseline or "rest" activity in the vestibular pathways and then modulating it according to the direction and velocity of head movements. The aim of this study was to assess whether a human subject could adapt to continuous electrical stimulation of the vestibular system, and whether it was possible to elicit artificial smooth oscillatory eye movements via modulation of the stimulation. Methods: One bilaterally deaf patient with bilateral vestibular loss received a custom-modified Med-El cochlear implant in which one electrode was implanted in the vicinity of the left posterior ampullary nerve. This electrode was activated with biphasic pulse trains of 400-mu s phase duration delivered at a repetition rate of 200 pulses per second. The resulting eye movements were recorded with 2-dimensional binocular video-oculography. Results: Successive "on-off" cycles of continuous electrical stimulation resulted in a progressively shorter duration of the nystagmic response. Once the adapted state was reached upon constant stimulation, amplitude or frequency modulations of electrical stimulation produced smooth oscillatory conjugated eye movements. Conclusions: Although this is a case study of one patient, the results suggest that humans can adapt to electrical stimulation of the vestibular system without too much discomfort. Once the subject is in the adapted state, the electrical stimulation call be modulated to artificially elicit smooth eye movements. Therefore, the major prerequisites for the feasibility of a vestibular implant for human use are fulfilled. C1 [Guyot, Jean-Philippe; Sigrist, Alain; Pelizzone, Marco; Kos, Maria Izabel] Univ Geneva, Univ Hosp, Otorhinolaryngol Head & Neck Surg Serv,Fac Med, Dept Clin Neurosci, Geneva, Switzerland. RP Guyot, JP (reprint author), Univ Hosp Geneva, Otorhinolaryngol Head & Neck Surg Serv, Rue Gabrielle Perret Gentil 4, CH-1211 Geneva 14, Switzerland. FU European Community [225929] FX From the Otorhinolaryngology-Head and Neck Surgery Service, Department of Clinical Neurosciences, University Hospital, Faculty of Medicine, University of Geneva, Geneva, Switzerland. This work was partly funded by the Seventh Framework Programme, Theme 3, Information and Communication Technologies; European Community CLONS (225929; Closed-loop Neural Prostheses for Vestibular Disorders), approved by the European Community on October 17, 2008. CR GACEK RR, 1974, ANN OTO RHINOL LARYN, V83, P596 Gacek R R, 1969, Acta Otolaryngol Suppl, V254, P1 GOLDBERG JM, 1971, J NEUROPHYSIOL, V34, P635 Guyot J-P, 2007, Ann Otolaryngol Chir Cervicofac, V124, P205 Guyot JP, 1999, ANN OTO RHINOL LARYN, V108, P151 Guyot JP, 2011, ANN OTO RHINOL LARYN, V120, P81 Halmagyi GM, 2010, RESTOR NEUROL NEUROS, V28, P37, DOI 10.3233/RNN-2010-0533 KEVETTER GA, 1989, BRAIN BEHAV EVOLUT, V34, P193, DOI 10.1159/000116505 Lewis RF, 2002, J VESTIBUL RES-EQUIL, V12, P87 Lewis RF, 2010, J NEUROPHYSIOL, V103, P1066, DOI 10.1152/jn.00241.2009 McCue MP, 1997, AM J OTOL, V18, P355 Merfeld DM, 2007, IEEE T BIO-MED ENG, V54, P1005, DOI 10.1109/TBME.2007.891943 Merfeld DM, 2006, IEEE T BIO-MED ENG, V53, P2362, DOI 10.1109/TBME.2006.883645 NICOUCAR K, 2006, SCHWEIZ MED FORU S29, pS132 Pournaras I, 2008, ACTA OTO-LARYNGOL, V128, P5, DOI 10.1080/00016480701275279 SUZUKI J, 1964, EXP NEUROL, V9, P137, DOI 10.1016/0014-4886(64)90013-5 Wall C, 2007, ANN OTO RHINOL LARYN, V116, P369 WILSON VJ, 1978, BRAIN RES, V143, P251, DOI 10.1016/0006-8993(78)90567-X NR 18 TC 23 Z9 24 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD MAR PY 2011 VL 120 IS 3 BP 143 EP 149 PG 7 WC Otorhinolaryngology SC Otorhinolaryngology GA 741BE UT WOS:000288837300001 PM 21510138 ER PT J AU Scott, AR Kudak, BAH Skinner, S Sidman, JD AF Scott, Andrew R. Kudak, Brent A. H. Skinner, Stanley Sidman, James D. TI Use of Intraoperative Laryngeal Electromyography to Evaluate Stridor in Children With Arthrogryposis SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE arthrogryposis; cricoarytenoid fixation; electromyography; recurrent laryngeal nerve; stridor; vocal fold immobility ID VOCAL FOLD PARALYSIS; MULTIPLEX CONGENITA; CORD PARALYSIS; THYROARYTENOID MUSCLES; CANINE MODEL; MANIFESTATIONS; MANAGEMENT AB Objectives: Arthrogryposis is a rare, congenital condition characterized by joint contractures of the extremities with muscle weakness and fibrosis. The otolaryngological manifestations of this disorder may include stridor, chronic aspiration, and Pierre Robin sequence, among others. Prior reports of vocal fold immobility associated with arthrogryposis have attributed it to recurrent laryngeal nerve paralysis, rather than to cricoarytenoid joint restriction. The objective of this study was to determine whether children with arthrogryposis and vocal fold immobility demonstrated laryngeal electromyography (L-EMG) findings consistent with recurrent laryngeal nerve paralysis or with cricoarytenoid joint restriction. Methods: A retrospective, institutional chart review of children with otolaryngological manifestations of arthrogryposis was performed; 6 children were identified. Three patients had vocal fold immobility documented by flexible laryngoscopy. These 3 children were prospectively evaluated with direct laryngoscopy and intraoperative L-EMG. Results: The 3 children with arthroaryposis and vocal fold dysfunction had laryngoscopy-confirmed vocal fold immobility or significant restriction of motion. The intraoperative L-EMG tracings obtained from all 3 patients demonstrated motor unit action potentials without evidence of denervation. Conclusions: This series, albeit small, suggests that the vocal fold dysfunction related to arthrogryposis may be attributable to cricoarytenoid joint restriction or poor laryngeal coordination, rather than to nerve paralysis, as originally postulated. C1 [Scott, Andrew R.] Floating Hosp Children, Tufts Med Ctr, Dept Otolaryngol, Boston, MA 02111 USA. [Sidman, James D.] Childrens Hosp & Clin Minnesota, Pediat ENT Associates, Minneapolis, MN USA. [Skinner, Stanley] Abbott NW Hosp, Inst Neurosci, Minneapolis, MN 55407 USA. [Kudak, Brent A. H.; Sidman, James D.] Univ Minnesota, Dept Otolaryngol, Minneapolis, MN USA. RP Scott, AR (reprint author), Floating Hosp Children, Tufts Med Ctr, Dept Otolaryngol, 800 Washington St,Box 850, Boston, MA 02111 USA. CR Bamshad M, 2009, J BONE JOINT SURG AM, V91A, P40, DOI 10.2106/JBJS.I.00281 Berkowitz RG, 1996, ANN OTO RHINOL LARYN, V105, P207 Berkowitz RG, 2009, ANN OTO RHINOL LARYN, V118, P791 COHEN SR, 1973, LARYNGOSCOPE, V83, P1293, DOI 10.1288/00005537-197308000-00013 COHEN SR, 1976, ANN OTO RHINOL LARYN, V85, P484 Daya H, 2000, ARCH OTOLARYNGOL, V126, P21 EPSTEIN JB, 1987, J ORAL MAXIL SURG, V45, P274 FAHY M J, 1990, Genetic Counseling, V1, P3 GARTLAN MG, 1993, ANN OTO RHINOL LARYN, V102, P695 HEFFEZ L, 1985, J ORAL MAXIL SURG, V43, P539 Kimaid P A T, 2004, Electromyogr Clin Neurophysiol, V44, P371 KOCH BM, 1987, PEDIATR NEUROL, V3, P288, DOI 10.1016/0887-8994(87)90070-1 LAUREANO AN, 1990, ANN OTO RHINOL LARYN, V99, P94 Munin MC, 2003, ARCH PHYS MED REHAB, V84, P1150, DOI 10.1016/S0003-9993(03)00146-1 PAUGH DR, 1988, INT J PEDIATR OTORHI, V16, P45, DOI 10.1016/0165-5876(88)90099-7 Sataloff RT, 2010, J VOICE, V24, P228, DOI 10.1016/j.jvoice.2008.08.005 Scott AR, 2010, ANN OTO RHINOL LARYN, V119, P54 Scott AR, 2009, ANN OTO RHINOL LARYN, V118, P56 Scott AR, 2008, INT J PEDIATR OTORHI, V72, P31, DOI 10.1016/j.ijporl.2007.09.011 Wohl DL, 2001, ANN OTO RHINOL LARYN, V110, P524 NR 20 TC 0 Z9 0 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD MAR PY 2011 VL 120 IS 3 BP 150 EP 154 PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA 741BE UT WOS:000288837300002 PM 21510139 ER PT J AU Olszewski, AE Shen, LS Jiang, JJ AF Olszewski, Aleksandra E. Shen, Lisa Jiang, Jack J. TI Objective Methods of Sample Selection in Acoustic Analysis of Voice SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE acoustic analysis; disordered voice; idiopathic Parkinson's voice; moving window; window selection ID JITTER MEASURES; TIME-SERIES; PERTURBATION; LOUDNESS; SHIMMER AB Objectives: In acoustic voice analysis, the fact that reproducible methods of sample selection have not been defined impedes research study generalizability and clinical assessment of treatment efficacy. Because perturbation results differ along a single signal, this study sought to establish objective methods of sample selection by use of a moving window to determine the most stable regions of phonation. Methods: Voice signals obtained from 21 patients affected by laryngeal conditions associated with Parkinson's disease were analyzed to study jitter, shimmer, signal-to-noise ratio, and correlation dimension parameters when various sample selection procedures were used. Objectively selected voice samples were chosen based upon 5%, 10%, and 20% variance from a signal's minimum perturbation value. The stability of these samples, defined by the standard deviations of the acoustic measurements, was compared to the stability of unselected samples and subjectively selected samples. Results: A significant decrease in standard deviation values of acoustic parameters was found in comparing the objectively selected samples (particularly those selected with 5% and 10% variance) to the subjectively selected and unselected samples. Conclusions: These results suggest that the development of an objective sample selection method may have significant effects on the stability and reliability of acoustic voice measurements. C1 [Jiang, Jack J.] Univ Wisconsin, Sch Med & Publ Hlth, Med Sci Ctr, Dept Surg,Div Otolaryngol Head & Neck Surg, Madison, WI 53706 USA. RP Jiang, JJ (reprint author), Univ Wisconsin, Sch Med & Publ Hlth, Med Sci Ctr, Dept Surg,Div Otolaryngol Head & Neck Surg, Room 5745,1300 Univ Ave, Madison, WI 53706 USA. FU National Institute on Deafness and Other Communication Disorders [1-R01DC05522-01] FX From the Department of Surgery, Division of Otolaryngology-Head and Neck Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin. The study was supported by NIH grant 1-R01DC05522-01 from the National Institute on Deafness and Other Communication Disorders. CR Bielamowicz S, 1996, J SPEECH HEAR RES, V39, P126 Brockmann M, 2008, J SPEECH LANG HEAR R, V51, P1152, DOI 10.1044/1092-4388(2008/06-0208) FERRAND CT, 1995, J VOICE, V9, P419, DOI 10.1016/S0892-1997(05)80204-8 FRASER AM, 1986, PHYS REV A, V33, P1134, DOI 10.1103/PhysRevA.33.1134 GLAZE LE, 1990, J VOICE, V4, P37, DOI 10.1016/S0892-1997(05)80080-3 Jiang JJ, 2009, FOLIA PHONIATR LOGO, V61, P342, DOI 10.1159/000252851 Jiang JJ, 2002, J ACOUST SOC AM, V112, P2127, DOI 10.1121/1.1509430 Jiang JJ, 2003, J ACOUST SOC AM, V114, P2198, DOI 10.1121/1.1610462 Jones TM, 2001, CLIN OTOLARYNGOL, V26, P29, DOI 10.1046/j.1365-2273.2001.00413.x KARNELL MP, 1991, J SPEECH HEAR RES, V34, P544 Kent RD, 2003, J COMMUN DISORD, V36, P281, DOI 10.1016/S0021-9924(03)00016-9 Lim JY, 2006, ACTA OTO-LARYNGOL, V126, P62, DOI 10.1080/00016480510043927 LINVILLE SE, 1990, J VOICE, V4, P45, DOI 10.1016/S0892-1997(05)80081-5 MacCallum JK, 2011, J VOICE, V25, P15, DOI 10.1016/j.jvoice.2009.08.004 MILENKOVIC P, 1987, J SPEECH HEAR RES, V30, P529 Munoz J, 2003, FOLIA PHONIATR LOGO, V55, P102, DOI 10.1159/000070092 PACKARD NH, 1980, PHYS REV LETT, V45, P712, DOI 10.1103/PhysRevLett.45.712 Petrovic-Lazic M, 2011, J VOICE, V25, P94, DOI 10.1016/j.jvoice.2009.04.002 Regner MF, 2008, LARYNGOSCOPE, V118, P1313, DOI 10.1097/MLG.0b013e31816e2ec7 Robinson JL, 2005, J VOICE, V19, P665, DOI 10.1016/j.jvoice.2005.04.001 Scherer RC, 1988, J VOICE, V2, P230, DOI 10.1016/S0892-1997(88)80081-X STASSEN HH, 1991, METHOD INFORM MED, V30, P44 Takens F., 1981, LECT NOTES MATH, V898, P366, DOI DOI 10.1007/BFB0091924 THEILER J, 1986, PHYS REV A, V34, P2427, DOI 10.1103/PhysRevA.34.2427 Titze I. R, 1995, WORKSH AC VOIC AN SU, P1 Vieira MN, 2002, J ACOUST SOC AM, V111, P1045, DOI 10.1121/1.1430686 Yu P, 2001, J VOICE, V15, P529, DOI 10.1016/S0892-1997(01)00053-4 Zhang Y, 2003, ELECTRON LETT, V39, P1021, DOI 10.1049/el:20030641 NR 28 TC 5 Z9 6 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD MAR PY 2011 VL 120 IS 3 BP 155 EP 161 PG 7 WC Otorhinolaryngology SC Otorhinolaryngology GA 741BE UT WOS:000288837300003 PM 21510140 ER PT J AU Mendelsohn, D Jeremic, G Wright, ED Rotenberg, BW AF Mendelsohn, Daniel Jeremic, Goran Wright, Erin D. Rotenberg, Brian W. TI Revision Rates After Endoscopic Sinus Surgery: A Recurrence Analysis SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE endoscopic sinus surgery; frontal sinus; nasal polyposis; revision surgery ID NASAL POLYPS; CHRONIC RHINOSINUSITIS; FOLLOW-UP; PREVALENCE; ETHMOIDECTOMY; INTOLERANCE; INTRANASAL; EXPERIENCE; ASPIRIN; DISEASE AB Objectives: Chronic rhinosinusitis with nasal polyposis is often refractory to medical and surgical management, especially in patients with asthma and aspirin intolerance. We used a contemporary database to investigate recurrence and revision surgery rates following endoscopic sinus surgery. Methods: We performed a cohort study using a survival analysis technique. Records were reviewed of 549 patients with nasal polyposis who underwent endoscopic sinus surgery over a 10-year period. The main outcome measure was disease-free and surgery-free survival following endoscopic sinus surgery, investigated with Kaplan-Meier analyses. Results: Patients with Samter's triad were significantly more likely to have a recurrence and undergo a second surgery following recurrence (risk-odds ratio, 2.7; 95% confidence interval, 1.5 to 3.2; p <0.01) than were patients without asthma or with only asthma from the triad. The presence of initial frontal sinus disease also increased the likelihood of revision surgery (risk-odds ratio, 1.6; 95% confidence interval, 1.2 to 1.8; p <0.05). Conclusions: This is the first study to use survival analysis to document revision surgery rates following endoscopic sinus surgery. Revision surgery occurs at a high rate, especially in patients with asthma, Samter's triad, or frontal sinus disease. Patients should routinely be informed during clinical consultations about the likelihood of recurrence. Early intervention for frontal sinus disease may be considered. C1 [Wright, Erin D.] Univ Alberta, Dept Surg, Div Otolaryngol Head & Neck Surg, Edmonton, AB, Canada. [Mendelsohn, Daniel; Jeremic, Goran; Rotenberg, Brian W.] Univ Western Ontario, Dept Otolaryngol Head & Neck Surg, London, ON, Canada. RP Rotenberg, BW (reprint author), St Josephs Hlth Care, 268 Grosvenor St, London, ON N6A 4V2, Canada. FU Schulich Research Opportunities Program Grant FX From the Department of Otolaryngology-Head and Neck Surgery, University of Western Ontario, London (Mendelsohn, Jeremic, Rotenberg), and the Division of Otolaryngology-Head and Neck Surgery, Department of Surgery, University of Alberta, Edmonton (Wright). Canada. This project was funded by the Schulich Research Opportunities Program Grant. CR Albu S, 2004, Acta Otorhinolaryngol Belg, V58, P79 Anderson T D, 2001, Curr Allergy Asthma Rep, V1, P282, DOI 10.1007/s11882-001-0020-8 Bhattacharyya N, 2005, LARYNGOSCOPE, V115, P2123, DOI 10.1097/01.mlg.0000183229.20452.65 Drake-Lee AB, 2004, HOSP MED, V65, P264 DRAKELEE AB, 1984, J LARYNGOL OTOL, V98, P783, DOI 10.1017/S0022215100147462 FRIEDMAN WH, 1990, LARYNGOSCOPE, V100, P343 Guerrero Jossana, 2007, Acta Otorrinolaringol Esp, V58, P252 Hedman J, 1999, INT J EPIDEMIOL, V28, P717, DOI 10.1093/ije/28.4.717 Jäntti-Alanko S, 1989, Rhinol Suppl, V8, P59 Johansson L, 2003, ANN OTO RHINOL LARYN, V112, P625 Kennedy D W, 1992, Laryngoscope, V102, P1 Kim JE, 2007, ENT-EAR NOSE THROAT, V86, P396 Larsen K, 1996, ALLERGY ASTHMA PROC, V17, P243, DOI 10.2500/108854196778662255 Larsen K, 1997, EUR ARCH OTO-RHINO-L, V254, pS85, DOI 10.1007/BF02439732 LAWSON W, 1991, LARYNGOSCOPE, V101, P367 Rinia AB, 2007, ALLERGY, V62, P348, DOI 10.1111/j.1398-9995.2007.01323.x SAMTER M, 1968, ANN INTERN MED, V68, P975 SCHAITKIN B, 1993, LARYNGOSCOPE, V103, P1117 Smith TL, 2005, LARYNGOSCOPE, V115, P2199, DOI 10.1097/01.mlg.0000182825.82910.80 Van Camp C., 1994, Rhinology (Utrecht), V32, P5 Vento SI, 2000, ANN ALLERG ASTHMA IM, V85, P209 Wynn R, 2004, LARYNGOSCOPE, V114, P811, DOI 10.1097/00005537-200405000-00004 1997, EAR NOSE THROAT J S, V76, P1 NR 23 TC 35 Z9 35 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD MAR PY 2011 VL 120 IS 3 BP 162 EP 166 PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA 741BE UT WOS:000288837300004 PM 21510141 ER PT J AU Karajanagi, SS Lopez-Guerra, G Park, H Kobler, JB Galindo, M Aanestad, J Mehta, DD Kumai, Y Giordano, N d'Almeida, A Heaton, JT Langer, R Herrera, VLM Faquin, W Hillman, RE Zeitels, SM AF Karajanagi, Sandeep S. Lopez-Guerra, Gerardo Park, Hyoungshin Kobler, James B. Galindo, Marilyn Aanestad, Jon Mehta, Daryush D. Kumai, Yoshihiko Giordano, Nicholas d'Almeida, Anthony Heaton, James T. Langer, Robert Herrera, Victoria L. M. Faquin, William Hillman, Robert E. Zeitels, Steven M. TI Assessment of Canine Vocal Fold Function After Injection of a New Biomaterial Designed to Treat Phonatory Mucosal Scarring SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE hoarseness; hydrogel; polyethylene glycol; scar ID EXTRACELLULAR-MATRIX; HYALURONIC-ACID; TISSUE-REPAIR; GROWTH-FACTOR; PHONOSURGERY; CORD AB Objectives: Most cases of irresolvable hoarseness are due to deficiencies in the pliability and volume of the superficial lamina propria of the phonatory mucosa. By using a US Food and Drug Administration approved polymer, polyethylene glycol (PEG), we created a novel hydrogel (PEG30) and investigated its effects on multiple vocal fold structural and functional parameters. Methods: We injected PEG30 unilaterally into 16 normal canine vocal folds with survival times of I to 4 months. Highspeed videos of vocal fold vibration, induced by intratracheal airflow, and phonation threshold pressures were recorded at 4 time points per subject. Three-dimensional reconstruction analysis of 11.7 T magnetic resonance images and histologic analysis identified 3 cases wherein PEG30 injections were the most superficial, so as to maximally impact vibratory function. These cases were subjected to in-depth analyses. Results: High-speed video analysis of the 3 selected cases showed minimal to no reduction in the maximum vibratory amplitudes of vocal folds injected with PEG30 compared to the non-injected, contralateral vocal fold. All PEG30-injected vocal folds displayed mucosal wave activity with low average phonation threshold pressures. No significant inflammation was observed on microlaryngoscopic examination. Magnetic resonance imaging and histologic analyses revealed time-dependent resorption of the PEG30 hydrogel by phagocytosis with minimal tissue reaction or fibrosis. Conclusions: The PEG30 hydrogel is a promising biocompatible candidate biomaterial to restore form and function to deficient phonatory mucosa, while not mechanically impeding residual endogenous superficial lamina propria. C1 [Kobler, James B.; Heaton, James T.; Langer, Robert; Hillman, Robert E.] MIT, Harvard Mit Div Hlth Sci & Technol, Cambridge, MA 02139 USA. [Karajanagi, Sandeep S.; Park, Hyoungshin; Langer, Robert] MIT, Dept Chem Engn, Cambridge, MA 02139 USA. [Herrera, Victoria L. M.] Boston Univ, Sch Med, Dept Med, Boston, MA 02118 USA. [Karajanagi, Sandeep S.; Lopez-Guerra, Gerardo; Park, Hyoungshin; Kobler, James B.; Kumai, Yoshihiko; Heaton, James T.; Hillman, Robert E.; Zeitels, Steven M.] Harvard Univ, Sch Med, Dept Surg, Boston, MA 02115 USA. [Giordano, Nicholas] Boston Univ, Sch Engn, Boston, MA 02118 USA. [Mehta, Daryush D.] Harvard Univ, Sch Engn & Appl Sci, Boston, MA 02115 USA. [Faquin, William] Harvard Univ, Sch Med, Dept Pathol, Boston, MA 02115 USA. [Karajanagi, Sandeep S.; Lopez-Guerra, Gerardo; Park, Hyoungshin; Kobler, James B.; Galindo, Marilyn; Aanestad, Jon; Mehta, Daryush D.; Kumai, Yoshihiko; d'Almeida, Anthony; Heaton, James T.; Hillman, Robert E.; Zeitels, Steven M.] Massachusetts Gen Hosp, Ctr Laryngeal Surg & Voice Rehabil, Boston, MA 02114 USA. [Faquin, William] Massachusetts Gen Hosp, Dept Pathol, Boston, MA 02114 USA. RP Karajanagi, SS (reprint author), Massachusetts Gen Hosp, Ctr Laryngeal Surg & Voice Rehabil, Bartlett Hall Extens 413, Boston, MA 02114 USA. FU Eugene B. Casey Foundation; Institute of Laryngology and Voice Restoration FX From the Center for Laryngeal Surgery and Voice Rehabilitation (Karajanagi, Lopez-Guerra, Park, Kobler, Galindo, Aanestad, Mehta, Kumai, d'Almeida, Heaton, Hillman, Zeitels) and the Department of Pathology (Faquin), Massachusetts General Hospital, the Departments of Surgery (Karajanagi, Lopez-Guerra, Park, Kobler, Kumai, Heaton, Hillman, Zeitels) and Pathology (Faquin), Harvard Medical School, the Department of Medicine, Boston University School of Medicine (Herrera), the School of Engineering and Applied Sciences, Harvard University (Mehta), and the School of Engineering, Boston University (Giordano), Boston, and the Department of Chemical Engineering (Karajanagi, Park, Langer) and the Harvard-MIT Division of Health Sciences and Technology (Kobler, Heaton, Langer, Hillman), Massachusetts Institute of Technology, Cambridge, Massachusetts. This work was supported in part by the Eugene B. Casey Foundation and the Institute of Laryngology and Voice Restoration. Dr Zeitels has an equity interest in Endocraft LLC. This study was performed in accordance with the PHS Policy on Humane Care and Use of Laboratory Animals, the NIH Guide for the care and Use of Laboratory Animals, and the Animal Welfare Act (7 U.S.C. et seq.); the animal use protocol was approved by the Institutional Animal Care and Use Committee (IACUC) of the Massachusetts General Hospital. CR ALLEN J, CURR OPIN O IN PRESS ARNOLD GE, 1955, ARCHIV OTOLARYNGOL, V62, P1 BLESS DM, CURR OPIN O IN PRESS BRUNINGS W, 1912, TECHNIQUE AUTOSCOPIC, P118 Chan RW, 1999, J ACOUST SOC AM, V106, P2008, DOI 10.1121/1.427947 CHHETRI DK, CURR OPIN O IN PRESS Duflo S, 2006, TISSUE ENG, V12, P2171, DOI 10.1089/ten.2006.12.2171 Finck C, 2005, LARYNGOSCOPE, V115, P1841, DOI 10.1097/01.mlg.0000173158.22274.8d Finck CL, 2010, J VOICE, V24, P626, DOI 10.1016/j.jvoice.2008.12.015 Hansen JK, 2005, ANN OTO RHINOL LARYN, V114, P662 Herrera VLM, 2009, LARYNGOSCOPE, V119, P2187, DOI 10.1002/lary.20643 Hillman R.E., 1998, ANN OTOL RHINOL S173, V107, P1 Hirano M., 1975, OTOLOGIA FUKUOKA S1, V21, P239 ISSHIKI N, 1978, ARCH OTOLARYNGOL, V104, P555 ISSHIKI N, 1974, ACTA OTO-LARYNGOL, V78, P451, DOI 10.3109/00016487409126379 Jahan-Parwar B, 2008, ANN OTO RHINOL LARYN, V117, P703 KISHIMOTO Y, CURR OPIN O IN PRESS Kishimoto Y, 2010, LARYNGOSCOPE, V120, P108, DOI 10.1002/lary.20642 LONG JL, CURR OPIN O IN PRESS Mehta DD, 2010, ANN OTO RHINOL LARYN, V119, P1 Molteni G, 2010, OTOLARYNG HEAD NECK, V142, P547, DOI 10.1016/j.otohns.2009.12.035 Payr E, 1915, DEUT MED WOCHENSCHR, V43, P1265 Roy N, 2004, J SPEECH LANG HEAR R, V47, P281, DOI 10.1044/1092-4388(2004/023) SATALOFF RT, CURR OPIN O IN PRESS SM Zeitels, 2007, ANN OTOL RHINOL S198, V116, P1 Suehiro A, 2010, ACTA OTO-LARYNGOL, V130, P844, DOI 10.3109/00016480903426618 Zeitels SM, 2003, NEW ENGL J MED, V349, P882, DOI 10.1056/NEJMra035148 ZEITELS SM, 1991, OTOLARYNG HEAD NECK, V105, P478 NR 28 TC 9 Z9 9 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD MAR PY 2011 VL 120 IS 3 BP 175 EP 184 PG 10 WC Otorhinolaryngology SC Otorhinolaryngology GA 741BE UT WOS:000288837300006 PM 21510143 ER PT J AU Huang, SF Lee, TJ Lee, YS Chen, CC Chin, SC Wang, NC AF Huang, Shiang-Fu Lee, Ta-Jen Lee, Yun-Shien Chen, Chien-Cheng Chin, Shy-Chi Wang, Ning-Chia TI Acute Rhinosinusitis-Related Orbital Infection in Pediatric Patients: A Retrospective Analysis SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE orbital cellulitis; pediatrics; sinusitis; subperiosteal abscess ID SUBPERIOSTEAL ABSCESS; MEDICAL-MANAGEMENT; SINUSITIS; CELLULITIS; CHILDREN; COMPLICATIONS; SECONDARY AB Objectives: Periorbital infection frequently originates from acute rhinosinusitis in children. We tried to find the characteristics of pediatric patients who are likely to develop subperiosteal orbital abscesses and to need emergency surgery for acute orbital swelling. Methods: in an observational retrospective cohort study, we reviewed 64 children less than 18 years of age who visited emergency rooms for periorbital swelling and were hospitalized with a diagnosis of periorbital cellulitis and subperiosteal orbital abscess between 1996 and 2007 at Chang Gung Memorial Hospital. The presence of periorbital abscess was diagnosed radiographically, and all of the patients had concomitant sinusitis that was proved by computed tomographic scan. Results: The mean age of the patients was 6.95 years, and 42 (65.63%) were male (male-to-female ratio, 1.91). Thirty patients (46.88%) had surgical drainage, and 34 (53.13%) received antibiotic therapy only. The factors associated on bi-variate analysis with abscess formation were age of 6 years or less (p = 0.023), proptosis (p = 0.012), fever (p <0.001), and a white blood cell count of more than 11,100 cells per microliter (p = 0.004). On multivariate analysis, fever and proptosis were independent factors that predicted abscess formation. In patients who underwent surgical drainage, the most frequently cultured microbes were Staphylococcus aureus, Streptococcus viridans, and coagulase-negative staphylococci, and 29% of our patients had polymicrobial pus cultures. Conclusions: The most important factor in predicting the failure of antibiotic treatment of sinusitis-related periorbital infections is abscess formation. Patients with fever and proptosis are prone to develop subperiosteal orbital abscesses. C1 [Huang, Shiang-Fu; Lee, Ta-Jen] Chang Gung Mem Hosp, Dept Otolaryngol, Tao Yuan 333, Taiwan. [Lee, Yun-Shien] Chang Gung Mem Hosp, Genom Med Res Core Lab, Tao Yuan 333, Taiwan. [Chen, Chien-Cheng; Chin, Shy-Chi] Chang Gung Mem Hosp, Dept Diagnost Radiol, Tao Yuan 333, Taiwan. [Chen, Chien-Cheng; Chin, Shy-Chi] Chang Gung Univ, Tao Yuan, Taiwan. [Lee, Yun-Shien] Ming Chuan Univ, Dept Biotechnol, Tao Yuan, Taiwan. [Wang, Ning-Chia] Univ Eye Ctr, Taipei, Taiwan. RP Huang, SF (reprint author), Chang Gung Mem Hosp, Dept Otolaryngol, 5 Fu Shin St, Tao Yuan 333, Taiwan. CR Bhargava D, 2001, RHINOLOGY, V39, P151 Brown CL, 2004, AM J RHINOL, V18, P321 CHANDLER JR, 1970, LARYNGOSCOPE, V80, P1414, DOI 10.1288/00005537-197009000-00007 Chang CH, 2000, J OCUL PHARMACOL TH, V16, P75, DOI 10.1089/jop.2000.16.75 DAVIS JP, 1994, POSTGRAD MED J, V70, P108 Givner LB, 2002, PEDIATR INFECT DIS J, V21, P1157, DOI 10.1097/01.inf.0000041790.79459.80 GOLDBERG F, 1978, PEDIATRICS, V62, P1000 Graham SM, 2002, LARYNGOSCOPE, V112, P986, DOI 10.1097/00005537-200206000-00009 Greenberg M F, 1998, J AAPOS, V2, P351, DOI 10.1016/S1091-8531(98)90033-7 HARRIS GJ, 1994, OPHTHALMOLOGY, V101, P585 HARRIS GJ, 1983, ARCH OPHTHALMOL-CHIC, V101, P751 Jain A, 2001, INT OPHTHALMOL CLIN, V41, P71, DOI 10.1097/00004397-200110000-00009 Nageswaran S, 2006, PEDIATR INFECT DIS J, V25, P695, DOI 10.1097/01.inf.0000227820.36036.f1 Noordzij JP, 2002, AM J RHINOL, V16, P97 Olshen R., 1984, CLASSIFICATION REGRE, V1st PATT BS, 1991, OTOLARYNG HEAD NECK, V104, P789 Rahbar R, 2001, ARCH OTOLARYNGOL, V127, P281 Sobol SE, 2002, J OTOLARYNGOL, V31, P131, DOI 10.2310/7070.2002.10979 SPIRES JR, 1986, LARYNGOSCOPE, V96, P763 Starkey CR, 2001, PEDIATR INFECT DIS J, V20, P1002, DOI 10.1097/00006454-200110000-00017 NR 20 TC 2 Z9 2 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD MAR PY 2011 VL 120 IS 3 BP 185 EP 190 PG 6 WC Otorhinolaryngology SC Otorhinolaryngology GA 741BE UT WOS:000288837300007 PM 21510144 ER PT J AU Weegerink, NJD Pennings, RJE Huygen, PLM Hoefsloot, LH Cremers, CWRJ Kunst, HPM AF Weegerink, Nicole J. D. Pennings, Ronald J. E. Huygen, Patrick L. M. Hoefsloot, Lies H. Cremers, Cor W. R. J. Kunst, Henricus P. M. TI Phenotypes of Two Dutch DFNA3 Families With Mutations in GJB2 SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE cochlear implantation; DFNA3; GJB2 ID SENSORINEURAL HEARING-LOSS; NON-SYNDROMIC DEAFNESS; PALMOPLANTAR KERATODERMA; MISSENSE MUTATION; CONNEXIN-26 GJB2; COCH MUTATION; DOMINANT; GENE; FEATURES; R75Q AB Objectives: We describe the phenotype of 2 Dutch DFNA3 families with mutations in the GJB2 gene. Methods: Two patients from family I and one isolated patient from family 2 were studied. The audiometric examination consisted of pure tone and speech audiometry. Two patients underwent vestibular testing and high-resolution computed tomographic scanning of the temporal bone. Mutation analysis of GJB2 and GJB6 was performed. Results: All 3 patients had severe to profound sensorineural hearing impairment. Cochlear implantation was performed in 2 patients, and their phoneme recognition scores were good. Mutation analyses revealed a p.Arg184Gln mutation in GJB2 in family 1 and a p.Arg75Trp mutation in GJB2 in family 2. No mutations in GJB6 were identified. Vestibular function tests and computed tomographic scans yielded normal findings in the examined subjects. Conclusions: Severe to profound sensorineural hearing impairment was found in these DFNA3 patients, and was well rehabilitated with cochlear implantation. A thorough genotype-phenotype correlation is difficult because of the small number of affected patients and the limited clinical data of these patients. More clinical data on DFNA3 families need to be published in order to create a reliable and precise phenotype characterization. C1 [Weegerink, Nicole J. D.; Pennings, Ronald J. E.; Huygen, Patrick L. M.; Hoefsloot, Lies H.; Cremers, Cor W. R. J.; Kunst, Henricus P. M.] Radboud Univ Nijmegen, Med Ctr, Dept Otorhinolaryngol, Donders Ctr Brain Cognit & Behav, NL-6500 HB Nijmegen, Netherlands. RP Weegerink, NJD (reprint author), Radboud Univ Nijmegen, Med Ctr, Dept Otorhinolaryngol, Donders Ctr Brain Cognit & Behav, POB 9101, NL-6500 HB Nijmegen, Netherlands. RI Kunst, Henricus/J-6456-2012; Pennings, Ronald/J-6651-2012 FU Heinsius Houbolt Foundation FX Front the Department of Otorhinolaryngology, Donders Center for Brain, Cognition and Behavior, Radboud University Nijmegen Medical Center, Nijmegen, the Netherlands. This study was supported by a grant from the Heinsius Houbolt Foundation. CR Birkenhager R, 2010, AM J MED GENET A, V152A, P1798, DOI 10.1002/ajmg.a.33464 Bischoff AMLC, 2006, OTOL NEUROTOL, V27, P323, DOI 10.1097/00129492-200604000-00006 Bischoff AMLC, 2005, OTOL NEUROTOL, V26, P918, DOI 10.1097/01.mao.0000185048.84641.e3 Cama E, 2009, INT J AUDIOL, V48, P12, DOI 10.1080/14992020802400654 de Heer AMR, 2009, ANN OTO RHINOL LARYN, V118, P313 Denoyelle F, 2002, ADV OTO-RHINO-LARYNG, V61, P47 Feldmann D, 2005, AM J MED GENET A, V137A, P225, DOI 10.1002/ajmg.a.30765 Hamelmann C, 2001, Hum Mutat, V18, P84, DOI 10.1002/humu.1156 International Standards Organization (ISO), 1984, 7029 ISO Janecke AR, 2001, HUM GENET, V108, P269, DOI 10.1007/s004390100484 Kelsell DP, 2001, AM J HUM GENET, V68, P559, DOI 10.1086/318803 Kemperman MH, 2005, OTOL NEUROTOL, V26, P926, DOI 10.1097/01.mao.0000185062.12458.87 Kudo T, 2003, HUM MOL GENET, V12, P995, DOI 10.1093/hmg/ddg116 Kunst H, 2000, AM J OTOL, V21, P181, DOI 10.1016/S0196-0709(00)80006-X Loffler J, 2001, EUR J HUM GENET, V9, P226, DOI 10.1038/sj.ejhg.5200607 Mani RS, 2009, EUR J HUM GENET, V17, P502, DOI 10.1038/ejhg.2008.179 Marziano NK, 2003, HUM MOL GENET, V12, P805, DOI 10.1093/hmg/ddg076 Matos TD, 2008, HEARING RES, V240, P87, DOI 10.1016/j.heares.2008.03.004 Melchionda S, 2005, BIOCHEM BIOPH RES CO, V337, P799, DOI 10.1016/j.bbrc.2005.09.116 Morle L, 2000, J MED GENET, V37, P368, DOI 10.1136/jmg.37.5.368 *NSDSK, 1984, INSTR EW HEAR TEST Pauw RJ, 2007, AUDIOL NEURO-OTOL, V12, P77, DOI 10.1159/000097794 Piazza V, 2005, CLIN GENET, V68, P161, DOI 10.1111/j.1399-0004.2005.00468.x Primignani P, 2003, CLIN GENET, V63, P516, DOI 10.1034/j.1399-0004.2003.00079.x Richard G, 1998, HUM GENET, V103, P393, DOI 10.1007/s004390050839 Sinnathuray AR, 2004, OTOL NEUROTOL, V25, P930, DOI 10.1097/00129492-200411000-00012 SMITH RJH, 2009, GENEREVIEWS Tekin M, 2001, CLIN GENET, V59, P269, DOI 10.1034/j.1399-0004.2001.590409.x van Drunen FJW, 2009, AUDIOL NEURO-OTOL, V14, P303, DOI 10.1159/000212109 Welch KO, 2007, AM J MED GENET A, V143A, P1567, DOI 10.1002/ajmg.a.31701 Yuan YY, 2009, AM J MED GENET A, V149A, P689, DOI 10.1002/ajmg.a.32461 Yum SW, 2010, NEUROBIOL DIS, V38, P226, DOI 10.1016/j.nbd.2010.01.010 NR 32 TC 6 Z9 6 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD MAR PY 2011 VL 120 IS 3 BP 191 EP 197 PG 7 WC Otorhinolaryngology SC Otorhinolaryngology GA 741BE UT WOS:000288837300008 PM 21510145 ER PT J AU Luo, JS Cui, PC Gao, PF Nan, H Liu, Z Sun, YZ AF Luo, Jia-Sheng Cui, Peng-Cheng Gao, Peng-Fei Nan, Hou Liu, Zhi Sun, Yong-Zhu TI Reconstruction of Tracheal Wall Defect With a Mesh Patch of Nickel-Titanium Shape-Memory Alloy SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE alloy; biomedical engineering; reconstruction; trachea ID EXPANDING NITINOL STENTS; STENOSIS; CARTILAGE; MUSCLE; FLAP AB Objectives: We explored the feasibility of reconstructing tracheal wall defects with a mesh patch fashioned from a nickel-titanium shape-memory alloy. Methods: A tracheal wall defect was first constructed surgically by resecting the anterior half of the tracheal wall between the second and sixth tracheal rings. The defect was reconstructed in 8 experimental animals by replacing the resected tracheal mucosa and tracheal cartilage with a pedicle skin flap, which was then enclosed in the mesh patch. In 4 control animals, only a pedicle skin flap with strap muscles was used in the reconstruction procedure. The performance of the animals was observed after surgery. At the end of the experiments, the reconstructed segment was harvested for anatomic evaluation. Results: In the experimental group, I animal died 5 days after the operation. Endoscopic and anatomic examination of the 7 animals that survived the observation period showed that the reconstructed trachea was stable, with sufficient airway space for breathing. All 4 control animals died after the operation. After observing successful completion of this operation in animals, we successfully used this method to repair a tracheal wall defect in a human victim of a traffic accident. Conclusions: Tracheal defects can be successfully reconstructed by use of a mesh patch of nickel-titanium shape-memory alloy as an extraluminal stent - a method that avoids complications associated with intraluminal stents. C1 [Luo, Jia-Sheng; Cui, Peng-Cheng; Gao, Peng-Fei; Nan, Hou; Liu, Zhi; Sun, Yong-Zhu] Fourth Mil Med Univ, Tangdu Hosp, Dept Otolaryngol Head & Neck Surg, Xian 710038, Shaanxi Prov, Peoples R China. RP Cui, PC (reprint author), Fourth Mil Med Univ, Tangdu Hosp, Dept Otolaryngol Head & Neck Surg, Xinshi Rd, Xian 710038, Shaanxi Prov, Peoples R China. CR Aidonis A, 2002, EUR ARCH OTO-RHINO-L, V259, P404, DOI 10.1007/s00405-002-0483-9 CASIANO RA, 1994, OTOLARYNG HEAD NECK, V111, P205, DOI 10.1016/S0194-5998(94)70593-3 Elliott MJ, 1996, EUR J CARDIO-THORAC, V10, P707, DOI 10.1016/S1010-7940(96)80328-9 Gaissert HA, 2003, J THORAC CARDIOV SUR, V126, P744, DOI 10.1016/S0022-5223(03)00361-1 GRILLO HC, 1995, J THORAC CARDIOV SUR, V109, P486, DOI 10.1016/S0022-5223(95)70279-2 Hafner B, 2000, LARYNGO RHINO OTOL, V79, P165 Hashizume K, 2004, J PEDIATR SURG, V39, P1769, DOI 10.1016/j.pedsurg.2004.08.008 Hopkins C, 2001, J LARYNGOL OTOL, V115, P935 Laccourreye O, 1996, ANN OTO RHINOL LARYN, V105, P944 Nakahira M, 2006, AURIS NASUS LARYNX, V33, P203, DOI 10.1016/j.anl.2005.09.009 *NAT AC SCI, 1985, GUID CAR US LAB AN Ryhanen J, 1998, J BIOMED MATER RES, V41, P481, DOI 10.1002/(SICI)1097-4636(19980905)41:3<481::AID-JBM19>3.0.CO;2-L Schick B, 2007, LARYNGO RHINO OTOL, V86, P358, DOI 10.1055/s-2006-945002 Sesterhenn AM, 2004, CARDIOVASC INTER RAD, V27, P355, DOI 10.1007/s00270-004-0091-8 Sparup Jørgen, 2002, Ugeskr Laeger, V164, P3858 Teng MS, 2005, ANN OTO RHINOL LARYN, V114, P822 NR 16 TC 2 Z9 2 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD MAR PY 2011 VL 120 IS 3 BP 198 EP 203 PG 6 WC Otorhinolaryngology SC Otorhinolaryngology GA 741BE UT WOS:000288837300009 PM 21510146 ER PT J AU Lee, YW Chung, YJ Juhn, SK Kim, Y Lin, JZ AF Lee, Yun-Woo Chung, Yunju Juhn, Steven K. Kim, Youngki Lin, Jizhen TI Activation of the Transforming Growth Factor Beta Pathway in Bacterial Otitis Media SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE bacterial otitis media; granulation tissue formation; microarray; rat; transforming growth factor beta pathway ID RAT MIDDLE-EAR; GONADOTROPIN-RELEASING-HORMONE; MUCOUS CELL METAPLASIA; SMOOTH-MUSCLE-CELLS; TGF-BETA; AIRWAY INFLAMMATION; GENE-EXPRESSION; SIGNAL-TRANSDUCTION; EPITHELIAL-CELLS; KAPPA-B AB Objectives: Granulation tissue is common in otitis media (OM), yet little is known about the signaling pathways in the formation of granulation tissue in response to infections. En this study, we sought to investigate the activation of the transforming growth factor beta (TGF-beta) signaling pathway in the formation of granulation tissue in response to middle ear pathogens. Methods: Rat OM models were made by inoculating pneumococcus type 6A or nontypeable Haemophilus influenzae into the middle ear cavity or by obstructing the eustachian tube. Various pathway activities in the middle ear mucosa were analyzed with microarrays. Results: The TGF-beta signaling pathway was highly regulated in the middle ear cleft with bacterial OM, but not in the ears with eustachian tube obstruction. In ears with bacterial OM, the TGF-beta signaling pathway products were higher in Haemophilus-infected ears than in pneumococcus-infected ears. Conclusions: Bacterial OM triggers granulation tissue to thrive in the middle ear cleft of rats. Nontypeable H influenzae is more potent than pneumococcus type 6A in the formation of granulation tissue. Eustachian tube obstruction alone did not contribute to granulation tissue formation in the middle ear. C1 [Lee, Yun-Woo; Chung, Yunju; Juhn, Steven K.; Kim, Youngki; Lin, Jizhen] Univ Minnesota, Dept Otolaryngol, Minneapolis, MN USA. RP Lin, JZ (reprint author), 216 Lions Res Bldg,2001 6th St SE, Minneapolis, MN 55455 USA. FU NIH, National Institute on Deafness and Other Communication Disorders [R01 DC008165, 00010055]; National Organization for Hearing Research FX From the Department of Otolaryngology, University of Minnesota, Minneapolis, Minnesota. Supported in part by NIH grant R01 DC008165 and supplement 00010055 from the National Institute on Deafness and Other Communication Disorders, and the National Organization for Hearing Research. This study was performed in accordance with the PHS Policy on Humane Care and Use of Laboratory Animals, the NIH Guide for the Care and Use of Laboratory Animals, and the Animal Welfare Act (7 U.S.C. et seq.); the animal use protocol was approved by the Institutional Animal Care and Use Committee (IACUC) of the University of Minnesota. CR Blobe GC, 2000, NEW ENGL J MED, V342, P1350, DOI 10.1056/NEJM200005043421807 Clancy RM, 2003, J LEUKOCYTE BIOL, V74, P959, DOI 10.1189/jlb.0603276 Cordeiro MF, 2000, INVEST OPHTH VIS SCI, V41, P756 Derynck R, 1998, CELL, V95, P737, DOI 10.1016/S0092-8674(00)81696-7 Derynck R, 2003, NATURE, V425, P577, DOI 10.1038/nature02006 Ding L, 2004, J CLIN ENDOCR METAB, V89, P5549, DOI 10.1210/jc.2004-0161 Flanders KC, 2004, INT J EXP PATHOL, V85, P47, DOI 10.1111/j.0959-9673.2004.00377.x Groneberg DA, 2004, EXP LUNG RES, V30, P223, DOI 10.1080/01902140490276320 Jono H, 2002, J BIOL CHEM, V277, P45547, DOI 10.1074/jbc.M206883200 Kawano H, 2002, ANN OTO RHINOL LARYN, V111, P415 KO TC, 1995, ONCOGENE, V10, P177 Kondo S, 2004, BBA-MOL CELL RES, V1693, P91, DOI 10.1016/j.bbamcr.2004.05.005 Lee CH, 2003, ENDOCRINOLOGY, V144, P2201, DOI 10.1210/en.2003-0288 Lee JJ, 1997, J EXP MED, V185, P2143, DOI 10.1084/jem.185.12.2143 Lin JZ, 2002, INT J PEDIATR OTORHI, V65, P203, DOI 10.1016/S0165-5876(02)00130-1 Lin JZ, 1999, ANN OTO RHINOL LARYN, V108, P762 Lyden D, 1999, NATURE, V401, P670, DOI 10.1038/44334 Minshall EM, 1997, AM J RESP CELL MOL, V17, P326 Nishiyama K, 2005, CIRCULATION, V112, pU256 Ohno I, 1996, AM J RESP CELL MOL, V15, P404 Olman MA, 2003, AM J PHYSIOL-LUNG C, V285, pL522, DOI 10.1152/ajplung.00110.2003 Phipps S, 2004, AM J RESP CELL MOL, V31, P626, DOI 10.1165/rcmb.2004-0193OC Rankin JA, 1996, P NATL ACAD SCI USA, V93, P7821, DOI 10.1073/pnas.93.15.7821 ROBERTS AB, 1992, KIDNEY INT, V41, P557, DOI 10.1038/ki.1992.81 Schnaper HW, 2003, AM J PHYSIOL-RENAL, V284, pF243, DOI 10.1152/ajprenal.00300.2002 Singh J, 2004, CURR OPIN DRUG DISC, V7, P437 SPORN MB, 1986, SCIENCE, V233, P532, DOI 10.1126/science.3487831 Tateossian Hilda, 2009, Pathogenetics, V2, P5, DOI 10.1186/1755-8417-2-5 Temann UA, 1998, J EXP MED, V188, P1307, DOI 10.1084/jem.188.7.1307 Toyama K, 2004, ANN OTO RHINOL LARYN, V113, P967 Tsuboi Y, 2002, ACTA OTO-LARYNGOL, V122, P153, DOI 10.1080/00016480252814153 van Hogerlinden M, 1999, CANCER RES, V59, P3299 Vignola AM, 1997, AM J RESP CRIT CARE, V156, P591 Volpert OV, 2002, CANCER CELL, V2, P473, DOI 10.1016/S1535-6108(02)00209-X Wang DJ, 2004, J BIOL CHEM, V279, P43725, DOI 10.1074/jbc.M407368200 Xu JX, 2003, J CLIN ENDOCR METAB, V88, P1350, DOI 10.1210/jc.2002-021325 Zavadil J, 2001, P NATL ACAD SCI USA, V98, P6686, DOI 10.1073/pnas.111614398 Zhu Zhou, 1999, Journal of Clinical Investigation, V103, P779, DOI 10.1172/JCI5909 NR 38 TC 6 Z9 7 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD MAR PY 2011 VL 120 IS 3 BP 204 EP 213 PG 10 WC Otorhinolaryngology SC Otorhinolaryngology GA 741BE UT WOS:000288837300010 PM 21510147 ER PT J AU Zeitels, SM de Alarcon, A Burns, JA Lopez-Guerra, G Hillman, RE AF Zeitels, Steven M. de Alarcon, Alessandro Burns, James A. Lopez-Guerra, Gerardo Hillman, Robert E. TI Posterior Glottic Diastasis: Mechanically Deceptive and Often Overlooked SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE cricoid cartilage; dysphonia; hoarseness; intubation; laryngofissure; laryngoplasty; larynx; stenosis; vocal cord; vocal fold ID VOCAL FOLD PARALYSIS; STENOSIS AB Dysphonia secondary to posterior glottic aerodynamic incompetence can often be recognizable acoustically, but difficult to document visually. This mechanical impairment in posterior glottic closure is the result of injury caused by airway instrumentation. The difficulty of recognition of this entity is due to posterior supraglottic soft tissue that obscures the complete view during posterior glottic adduction, the lack of a structural organization of the cricoarytenoid region injury that leads to this disorder, and the lack of nomenclature. A retrospective assessment was done on 3 patients who underwent surgical reconstruction to correct posterior phonatory incompetence subsequent to laryngotracheal intubation. All 3 had sustained an injury to the cricoarytenoid joints, and 2 of the 3 had undergone paraglottic space medialization laryngoplasty that failed to solve the posterior glottic insufficiency. New procedures were designed and performed in these patients to correct the posterior glottic incompetence and are described: laryngofissure and partial posterior cricoid resection, endoscopic pharyngoepiglottic-aryepiglottic fold advancement-rotation flap with interarytenoid interposition, and interarytenoid submucosal implant augmentation. Although the academic literature is replete with reports describing stenosis resulting from impaired cricoarytenoid joint abduction, the term glottic diastasis provides nomenclature for the inability to normally adduct the arytenoid cartilages. The initial experience with surgical reconstruction is preliminary, but encouraging. C1 [Zeitels, Steven M.; Burns, James A.; Lopez-Guerra, Gerardo; Hillman, Robert E.] Massachusetts Gen Hosp, Ctr Laryngeal Surg & Voice Rehabil, Boston, MA 02114 USA. [Zeitels, Steven M.; Burns, James A.; Lopez-Guerra, Gerardo; Hillman, Robert E.] Harvard Univ, Sch Med, Dept Surg, Boston, MA 02115 USA. [de Alarcon, Alessandro] Univ Cincinnati, Coll Med, Dept Otolaryngol Head & Neck Surg, Cincinnati, OH USA. [de Alarcon, Alessandro] Cincinnati Childrens Hosp Med Ctr, Cincinnati, OH USA. RP Zeitels, SM (reprint author), Massachusetts Gen Hosp, Ctr Laryngeal Surg & Voice Rehabil, 1 Bowdoin Sq,11th Floor, Boston, MA 02114 USA. FU Eugene B. Casey Foundation; Institute of Laryngology and Voice Restoration FX This work was supported in part by the Eugene B. Casey Foundation and the Institute of Laryngology and Voice Restoration. CR Bastian RW, 2001, OTOLARYNG HEAD NECK, V124, P625, DOI 10.1067/mhn.2001.116036 Benjamin B, 2008, ANN OTOL RHINOL S200, V117, P1 Burns JA, 2004, LARYNGOSCOPE, V114, P1864, DOI 10.1097/00005537-200410000-00035 COTTON RT, 1991, LARYNGOSCOPE, V101, P1, DOI 10.1288/00005537-199112000-00001 Hillman R.E., 1998, ANN OTOL RHINOL S173, V107, P1 Hogikyan ND, 2000, J VOICE, V14, P378, DOI 10.1016/S0892-1997(00)80083-1 JACKSON C, 1937, LARYNX ITS DIS, P194 JACKSON C, 1937, LARYNX ITS DIS, P447 KOUFMAN JA, 1991, LARYNGOSCOPE, V101, P1 Koufman JA, 2004, LARYNGOSCOPE, V114, P1529, DOI 10.1097/00005537-200409000-00004 LOUIS A, 1848, OBSERVATIONS SURG DI, P214 MACKENZIE M, 1880, DIS PHARYNX LARYNX T, P192 ODWYER J, 1886, MED REC NY, V29, P641 Rutter MJ, 2004, ARCH OTOLARYNGOL, V130, P737, DOI 10.1001/archotol.130.6.737 SMITH ME, 1993, INT J PEDIATR OTORHI, V25, P173, DOI 10.1016/0165-5876(93)90051-4 SOLISCOHEN J, 1880, DIS THROAT GUIDE DIA, P586 Vijayasekaran S, 2006, ARCH OTOLARYNGOL, V132, P1342, DOI 10.1001/archotol.132.12.1342 Zeitels SM, 2002, ANN OTOL RHINOL S190, V111, P1 Zeitels SM, 2004, J LARYNGOL OTOL, V118, P508 ZEITELS SM, 2007, TRACHEOTOMY AIRWAY M, P1 NR 20 TC 2 Z9 2 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD FEB PY 2011 VL 120 IS 2 BP 71 EP 80 PG 10 WC Otorhinolaryngology SC Otorhinolaryngology GA 720JP UT WOS:000287277300001 PM 21391417 ER PT J AU Guyot, JP Sigrist, A Pelizzone, M Feigl, GC Kos, MI AF Guyot, Jean-Philippe Sigrist, Alain Pelizzone, Marco Feigl, Georg C. Kos, Maria Izabel TI Eye Movements in Response to Electrical Stimulation of the Lateral and Superior Ampullary Nerves SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE imbalance; implant; prosthesis; rehabilitation; vestibule ID DELAYED FACIAL PALSY; MIDDLE-EAR SURGERY; SEMICIRCULAR CANAL PROSTHESIS; VESTIBULAR PROSTHESIS; COCHLEAR IMPLANTATION; PARALYSIS; VIRUS; REACTIVATION; DISORDERS; SYSTEM AB Objectives: Recently, we demonstrated that it was possible to elicit vertical eye movements in response to electrical stimulation of the posterior ampullary nerve. In order to develop a vestibular implant, a second site of stimulation is required to encode the horizontal movements. Methods: Three patients with disabling Meniere's disease were included in the study. Before a labyrinthectomy via a standard transcanal approach was performed, their lateral and anterior ampullary nerves were surgically exposed under local anesthesia through a procedure we recently developed. The attic was opened, the incus and malleus head were removed, and a small well was drilled above the horizontal portion of the facial nerve canal to place an electrode. This electrode was used to deliver balanced biphasic trains of electrical pulses. Results: The electrical stimuli elicited mainly horizontal nystagmus without simultaneous stimulation of the facial nerve. Conclusions: It is possible to stimulate electrically the lateral and superior ampullary nerves without simultaneous stimulation of the facial nerve. Because the nerves run close to each other, electrical stimulation provoked eye movements that were not purely horizontal, but also had some vertical components. Nevertheless, this site can be used to encode horizontal movements, because central adaptation may correct unnatural afferent vestibular cues delivered by a prosthetic sensor. The range of stimulus intensities that produced a response was broad enough for us to envision the possibility of encoding eye movements of various speeds. C1 [Guyot, Jean-Philippe; Sigrist, Alain; Pelizzone, Marco; Kos, Maria Izabel] Univ Geneva, Otorhinolaryngol Head & Neck Surg Serv, Univ Hosp Geneva, Dept Clin Neurosci,Fac Med, CH-1211 Geneva 14, Switzerland. [Feigl, Georg C.] Med Univ Graz, Inst Anat, Graz, Austria. RP Guyot, JP (reprint author), Univ Geneva, Otorhinolaryngol Head & Neck Surg Serv, Univ Hosp Geneva, Dept Clin Neurosci,Fac Med, Rue Gabrielle Perret Gentil 4, CH-1211 Geneva 14, Switzerland. FU European Community [225929] FX This work was partly funded by the Seventh Framework Programme, Theme 3, Information and Communication Technologies; European Community CLONS (225929; Closed-loop Neural Prostheses for Vestibular Disorders), approved by the European Community on October 17,2008. CR Bigelow DC, 1998, AM J OTOL, V19, P163 Bonkowsky V, 1998, ANN OTO RHINOL LARYN, V107, P901 Committee on Hearing and Equilibirum, 1995, OTOLARYNGOL HEAD NEC, V113, P181 Della Santina CC, 2007, IEEE T BIO-MED ENG, V54, P1016, DOI 10.1109/TBME.2007.894629 De Stefano A, 2009, B-ENT, V5, P47 Dulguerov P, 1999, LARYNGOSCOPE, V109, P754, DOI 10.1097/00005537-199905000-00014 Feigl GC, 2009, OTOL NEUROTOL, V30, P586, DOI 10.1097/MAO.0b013e3181ab9164 Fridman GY, 2010, JARO-J ASSOC RES OTO, V11, P367, DOI 10.1007/s10162-010-0208-5 Gacek RR, 1999, AM J OTOLARYNG, V20, P202, DOI 10.1016/S0196-0709(99)90001-7 GACEK RR, 1974, ANN OTO RHINOL LARYN, V83, P596 Gacek Richard R, 2002, Adv Otorhinolaryngol, V60, P32 GOLDBERG JM, 1971, J NEUROPHYSIOL, V34, P635 Gong WS, 2000, ANN BIOMED ENG, V28, P572, DOI 10.1114/1.293 Gong WS, 2008, IEEE T BIO-MED ENG, V55, P2608, DOI 10.1109/TBME.2008.2001294 Gong WS, 2002, IEEE T BIO-MED ENG, V49, P175, DOI 10.1109/10.979358 GUYOT JP, 2002, MED HYG, V60, P1954 Gyo K, 1999, J LARYNGOL OTOL, V113, P914 HOUSE JW, 1985, OTOLARYNG HEAD NECK, V93, P146 Kelsall DC, 1997, AM J OTOL, V18, P336 Kitahara Tadashi, 2006, Nihon Jibiinkoka Gakkai Kaiho, V109, P600 Krause E, 2010, OTOLARYNG HEAD NECK, V142, P809, DOI 10.1016/j.otohns.2010.01.017 Lewis RF, 2002, J VESTIBUL RES-EQUIL, V12, P87 Merfeld DM, 2007, IEEE T BIO-MED ENG, V54, P1005, DOI 10.1109/TBME.2007.891943 Merfeld DM, 2006, IEEE T BIO-MED ENG, V53, P2362, DOI 10.1109/TBME.2006.883645 MUCKLE RP, 1994, AM J OTOL, V15, P394 Ng M, 1999, AM J OTOL, V20, P421 Safdar A, 2006, J LARYNGOL OTOL, V120, P745, DOI 10.1017/S0022215106002258 SCHUKNECHT H F, 1956, Laryngoscope, V66, P859, DOI 10.1288/00005537-195607000-00005 Shea JJ, 2001, OTOL NEUROTOL, V22, P465, DOI 10.1097/00129492-200107000-00009 Vrabec JT, 1999, AM J OTOL, V20, P26 Wagner JH, 2010, EUR ARCH OTO-RHINO-L, V267, P1849, DOI 10.1007/s00405-010-1320-1 Wall C, 2007, ANN OTO RHINOL LARYN, V116, P369 Wall C, 2002, J VESTIBUL RES-EQUIL, V12, P95 Wu Wenming, 2004, Lin Chuang Er Bi Yan Hou Ke Za Zhi, V18, P200 Zheng CQ, 1996, AM J OTOL, V17, P200 NR 35 TC 21 Z9 21 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD FEB PY 2011 VL 120 IS 2 BP 81 EP 87 PG 7 WC Otorhinolaryngology SC Otorhinolaryngology GA 720JP UT WOS:000287277300002 PM 21391418 ER PT J AU Stupak, HD AF Stupak, Howard D. TI Endonasal Repositioning of the Upper Lateral Cartilage and the Internal Nasal Valve SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE nasal airflow; nasal valve; upper lateral cartilage ID SECONDARY RHINOPLASTY; COLLAPSE; OBSTRUCTION; SURGERY; GRAFTS; REPAIR AB Objectives: Collapse of the upper lateral cartilage (ULC) is associated with narrowing of the internal nasal valve (INV). The goal of this article is to describe a novel procedure that repositions the ULC, opening the INV, without implants, grafts, or permanent sutures. Methods: Before-and-after digital photographs of patients with ULC and INV collapse who underwent endonasal ULC repositioning were analyzed. The surgical procedure consists of an intercartilaginous incision and the creation of a surface that permits scarification upon cartilage reapproximation. Precise placement of a support apparatus permits the ULC to heal into a position in direct contact with the lower lateral cartilage, thus dilating the INV. The percentage of collapse of the ULC (PCULC), determined by ULC shape measurements made with computer-aided design software, was compared on before-and-after photographs by use of Student's t-test (paired). Results: The study included 52 patients (79 procedures) followed for 1 to 18 months after surgery in the period 2007 to 2009. There were no complications or revision surgeries. The preoperative mean PCULC was 58.6%. The postoperative mean PCULC was 5.7% (p <0.0001). Conclusions: Repair of the INV via ULC repositioning is a simple, relatively safe procedure that produces a statistically significant improvement in the PCULC. The functional change at the INV may be inferred from the ULC shape, but further prospective clinical studies are required. C1 [Stupak, Howard D.] Albert Einstein Coll Med, Dept Otolaryngol Head & Neck Surg, Bronx, NY 10467 USA. RP Stupak, HD (reprint author), 163 Main St, Westport, CT 06880 USA. CR Andre RE, 2008, RHINOLOGY, V46, P66 Armengot M, 2003, RHINOLOGY, V41, P107 Bruno JR, 2005, PLAST RECONSTR SURG, V116, P685, DOI 10.1097/01.prs.0000175963.09162.9e Clark JM, 2002, LARYNGOSCOPE, V112, P1917, DOI 10.1097/00005537-200211000-00002 Constantian MB, 1996, PLAST RECONSTR SURG, V98, P38, DOI 10.1097/00006534-199607000-00007 Dolan RW, 2010, ARCH OTOLARYNGOL, V136, P292, DOI 10.1001/archoto.2010.1 Friedman M, 2004, OTOLARYNG HEAD NECK, V131, P519, DOI 10.1016/j.otohns.2004.03.035 Ingels KJAO, 2008, ARCH FACIAL PLAST S, V10, P354, DOI 10.1001/archfaci.10.5.354 Mendelsohn MS, 2006, ARCH FACIAL PLAST S, V8, P293, DOI 10.1001/archfaci.8.5.293 Park SS, 1998, PLAST RECONSTR SURG, V101, P1120, DOI 10.1097/00006534-199804040-00036 Ricci E, 2001, AM J RHINOL, V15, P307 SHEEN JH, 1984, PLAST RECONSTR SURG, V73, P230, DOI 10.1097/00006534-198402000-00013 Spielmann PM, 2009, LARYNGOSCOPE, V119, P1281, DOI 10.1002/lary.20495 Toriumi DM, 1997, ARCH OTOLARYNGOL, V123, P802 NR 14 TC 1 Z9 1 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD FEB PY 2011 VL 120 IS 2 BP 88 EP 94 PG 7 WC Otorhinolaryngology SC Otorhinolaryngology GA 720JP UT WOS:000287277300003 PM 21391419 ER PT J AU Holt, JJ AF Holt, James J. TI Superior Mesotympanic Sinus SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE middle ear; posterior tympanum; mesotympanic sinus ID RETROFACIAL APPROACH; TYMPANI AB Objectives: This study of the posterior tympanum was performed to better define the anatomy of this complex area of the middle ear. A sinus previously not described was examined. Methods: The posterior tympanum of 49 temporal bones was studied by microscopic techniques. The sinus depth, the opening into the sinus, and the relationship of the facial nerve to the sinus were documented. Results: A sinus lying in the superior part of the posterior tympanum was discovered: the superior mesotympanic sinus. The depth of the sinus was from 0.5 to 2 mm, and it was present in 42 of the 49 specimens (86%). The superior border of the sinus is the facial nerve, which was dehiscent in 9 cases. Conclusions: The surgeon can remove disease with more confidence from the tympanum if he or she knows that disease may harbor in this sinus, and that injury to the facial nerve must be avoided. C1 Marshfield Clin Fdn Med Res & Educ, Dept Otolaryngol Head & Neck Surg, Marshfield, WI 54449 USA. RP Holt, JJ (reprint author), Marshfield Clin Fdn Med Res & Educ, Dept Otolaryngol Head & Neck Surg, 1000 N Oak Ave, Marshfield, WI 54449 USA. FU Marshfield Clinic Research Foundation FX The author thanks Marshfield Clinic Research Foundation for its support through the assistance of Marie Fleisner in the preparation of this manuscript, and Dr Po Chyou for statistical analysis and support. The author further thanks Shirley Thompson for creating the drawing and Dean Kuehmichel for assistance with the graphics. CR [Anonymous], 2007, DORLANDS ILLUSTRATED Holt James J, 2004, Ear Nose Throat J, V83, P241 Holt JJ, 2005, OTOL NEUROTOL, V26, P1122, DOI 10.1097/01.mao.0000194887.59270.7d Holt JJ, 2007, ANN OTO RHINOL LARYN, V116, P457 Marchioni D, 2009, OTOL NEUROTOL, V30, P758, DOI 10.1097/MAO.0b013e3181b0503e Ozturan O, 1996, ANN OTO RHINOL LARYN, V105, P776 PICKETT BP, 1995, AM J OTOL, V16, P741 PROCTOR B, 1969, ANN OTO RHINOL LARYN, V78, P1026 SAITO R, 1971, ARCHIV OTOLARYNGOL, V94, P418 NR 9 TC 0 Z9 0 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD FEB PY 2011 VL 120 IS 2 BP 95 EP 98 PG 4 WC Otorhinolaryngology SC Otorhinolaryngology GA 720JP UT WOS:000287277300004 PM 21391420 ER PT J AU Petersson, RS Wetjen, NM Thompson, DM AF Petersson, Rajanya S. Wetjen, Nicholas M. Thompson, Dana M. TI Neurologic Variant Laryngomalacia Associated With Chiari Malformation and Cervicomedullary Compression: Case Reports SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE brain stem compression; Chiari malformation; laryngomalacia; stridor ID RESPIRATORY OBSTRUCTION; LARYNGEAL STRIDOR; SUPRAGLOTTOPLASTY; INFANTS; MENINGOMYELOCELE; CHILDREN; APNEA AB Two infants presented with intermittent stridor and evidence of laryngomalacia on flexible laryngoscopy. The first was a 10-month-old girl who had undergone 3 supraglottoplasty surgeries at an outside institution, without long-term resolution of symptoms. She was found during our evaluation to have a Chiari malformation. Laryngomalacia symptoms resolved after suboccipital decompression and C I laminectomy, and the patient remained symptom-free at 6-month follow-up. The second infant was a 24-day-old boy with velocardiofacial syndrome who was found to have posterior cervicomedullary junction compression at the level of C I. He underwent Cl laminectomy for decompression of the brain stem, which resulted in immediate resolution of symptoms, and he remained symptom-free at 12-month follow-up. Neurologic abnormalities have been reported in up to 50% of infants with laryngomalacia. As such, brain stem dysfunction should be considered among the causes of laryngomalacia during evaluation, especially in patients with failure of supraglottoplasty. Both of these infants had resolution of symptoms after their neurosurgical procedures. C1 [Thompson, Dana M.] Mayo Clin, Div Pediat Otorhinolaryngol, Rochester, MN 55905 USA. [Thompson, Dana M.] Mayo Eugenio Litta Childrens Hosp, Rochester, MN USA. [Petersson, Rajanya S.; Thompson, Dana M.] Mayo Clin, Dept Otorhinolaryngol, Rochester, MN 55905 USA. [Wetjen, Nicholas M.] Mayo Clin, Dept Neurol Surg, Rochester, MN 55905 USA. RP Thompson, DM (reprint author), Mayo Clin, Div Pediat Otorhinolaryngol, 200 1st St SW, Rochester, MN 55905 USA. CR COCHRANE DD, 1991, PEDIATR NEUROSURG, V16, P232 Denoyelle F, 2003, ARCH OTOLARYNGOL, V129, P1077, DOI 10.1001/archotol.129.10.1077 FITZSIMM.JS, 1965, ARCH DIS CHILD, V40, P687 Hoff SR, 2010, INT J PEDIATR OTORHI, V74, P245, DOI 10.1016/j.ijporl.2009.11.012 HOLINGER PC, 1978, J PEDIATR-US, V92, P368, DOI 10.1016/S0022-3476(78)80421-1 KRIEGER AJ, 1976, LARYNGOSCOPE, V86, P718, DOI 10.1288/00005537-197605000-00013 MCCLURG FLD, 1994, LARYNGOSCOPE, V104, P247 MORLEY AR, 1969, DEV MED CHILD NEUROL, V11, P471 Olney DR, 1999, LARYNGOSCOPE, V109, P1770, DOI 10.1097/00005537-199911000-00009 PAPASOZOMENOS S, 1981, NEUROLOGY, V31, P97 Portier F, 2001, INT J PEDIATR OTORHI, V57, P195, DOI 10.1016/S0165-5876(00)00439-0 PRESCOTT CAJ, 1991, AM J OTOLARYNG, V12, P230, DOI 10.1016/0196-0709(91)90123-W Reddy DK, 2001, ARCH OTOLARYNGOL, V127, P694 Richter GT, 2008, OTOLARYNG CLIN N AM, V41, P837, DOI 10.1016/j.otc.2008.04.011 ROGER G, 1995, LARYNGOSCOPE, V105, P1111, DOI 10.1288/00005537-199510000-00018 SMITH M E, 1959, J Laryngol Otol, V73, P188, DOI 10.1017/S002221510005516X Thompson DM, 2007, LARYNGOSCOPE, V117, P1, DOI 10.1097/MLG.0b013e31804a5750 Toynton SC, 2001, J LARYNGOL OTOL, V115, P35 NR 18 TC 4 Z9 4 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD FEB PY 2011 VL 120 IS 2 BP 99 EP 103 PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA 720JP UT WOS:000287277300005 PM 21391421 ER PT J AU Choi, JH Kim, EJ Choi, J Kwon, SY Lee, HM Kim, TH Lee, SH Shin, C Lee, SH AF Choi, Ji Ho Kim, Eun Joong Choi, June Kwon, Soon Young Lee, Heung Man Kim, Tae Hoon Lee, Sang Hag Shin, Chol Lee, Seung Hoon TI Effect of Successful Surgical Treatment on Changes of Position During Sleep in Adults With Obstructive Sleep Apnea Syndrome SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE adult; arousal; obstructive sleep apnea syndrome; polysomnography; surgery ID PRACTICE PARAMETERS; SURGERY; AIRWAY; RISK AB Objectives: The purpose of this study was to evaluate the changes of position during sleep as determined by polysomnography before and after upper airway surgery for obstructive sleep apnea syndrome in patients with no response to surgery ("nonresponse group") and in those who did have a response to surgery ("response group"). Methods: We analyzed a total of 106 polysomnograms from 53 subjects and compared the preoperative-postoperative differences in the frequency of positional changes during sleep and the distribution of sleep positions between the nonresponse group (n = 25) and the response group (n = 28). Surgical response was defined as a greater than 50% decrease in the postoperative apnea-hypopnea index. Results: The positional change index in the response group was significantly reduced (from 4.2 +/- 3.8 to 2.6 +/- 1.6; p = 0.038), whereas the positional change index in the nonresponse group did not significantly change (from 3.4 +/- 2.0 to 3.4 +/- 2.1; p = 0.861). The proportion of sleep time spent in the supine position did not significantly change in the nonresponse group (from 62.4% +/- 18.1% to 60.5% +/- 21.3%; p = 0.904) or the response group (from 55.5% +/- 23.9% to 60.1% +/- 23.1%; p = 0.412). Conclusions: The frequency of positional changes during sleep was significantly decreased with the improvement of respiratory disturbances and arousals in the response group after upper airway surgery. C1 [Choi, Ji Ho; Kim, Eun Joong; Choi, June; Kwon, Soon Young; Lee, Heung Man; Kim, Tae Hoon; Lee, Sang Hag; Lee, Seung Hoon] Korea Univ, Coll Med, Dept Otorhinolaryngol Head & Neck Surg, Seoul 136705, South Korea. [Shin, Chol] Korea Univ, Coll Med, Div Resp & Crit Care Med, Dept Internal Med, Seoul 136705, South Korea. RP Lee, SH (reprint author), Korea Univ, Coll Med, Ansan Hosp, Dept Otorhinolaryngol Head & Neck Surg, 516 Gojan Dong, Ansan 425707, Gyeonggi Do, South Korea. EM shleeent@korea.ac.kr; shleeent@korea.ac.kr RI Choi, June/E-7063-2013 FU Ministry for Health, Welfare and Family Affairs, Republic of Korea [A090084] FX This study was supported by a grant from the Korea Healthcare Technology R&D Project, Ministry for Health, Welfare and Family Affairs, Republic of Korea (A090084). CR AASM, 2007, AASM MAN SCOR SLEEP American Academy of Sleep Medicine, 2005, INT CLASS SLEEP DIS, V2nd American Thoracic Society, 1994, AM J RESP CRIT CARE, V150, P1463 [Anonymous], 1996, SLEEP, V19, P152 Choi JH, 2009, SLEEP BIOL RHYTHMS, V7, P181, DOI 10.1111/j.1479-8425.2009.00401.x Choi JH, 2009, AM J RHINOL ALLERGY, V23, pE56, DOI 10.2500/ajra.2009.23.3363 GUILLEMINAULT C, 1987, PSYCHIAT CLIN N AM, V10, P607 KATSANTONIS GP, 1990, LARYNGOSCOPE, V100, P1068, DOI 10.1288/00005537-199010000-00008 Kushida CA, 2006, SLEEP, V29, P375 Kushida CA, 2006, SLEEP, V29, P240 Morgenthaler TI, 2006, SLEEP, V29, P1031 Newman AB, 2001, AM J EPIDEMIOL, V154, P50, DOI 10.1093/aje/154.1.50 Powell N, 1996, SLEEP, V19, P593 Powell NB, 2009, CLIN EXP OTORHINOLAR, V2, P107, DOI 10.3342/ceo.2009.2.3.107 Riley RW, 2000, OTOLARYNG HEAD NECK, V122, P415, DOI 10.1016/S0194-5998(00)70058-1 Sher AE, 1996, SLEEP, V19, pS88 YOUNG T, 1993, NEW ENGL J MED, V328, P1230, DOI 10.1056/NEJM199304293281704 NR 17 TC 2 Z9 2 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD FEB PY 2011 VL 120 IS 2 BP 104 EP 109 PG 6 WC Otorhinolaryngology SC Otorhinolaryngology GA 720JP UT WOS:000287277300006 PM 21391422 ER PT J AU Sesterhenn, AM Schotte, TL Bauhofer, A Timmesfeld, N Wiegand, S Werner, JA Ovassapian, A Torossian, A AF Sesterhenn, Andreas M. Schotte, Tobias L. Bauhofer, Artur Timmesfeld, Nina Wiegand, Susanne Werner, Jochen A. Ovassapian, Andranik Torossian, Alexander TI Head and Neck Cancer Surgery in the Elderly: Outcome Evaluation With the McPeek Score SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE elderly; head and neck cancer; McPeek score; outcome; surgery ID SQUAMOUS-CELL CARCINOMA; MAJOR HEAD; COMPLICATIONS; AGE; SURVIVAL AB Objectives: There is international consensus that elderly patients with head and neck cancer should be treated curatively, like younger patients. Because of common comorbidities in elderly patients, perioperative complications are likely. The McPeek postoperative outcome score was used to evaluate the success of surgical interventions in patients with head and neck cancer. Methods: We included 168 patients in the study (56 in the study group, 75 years of age or more; and 112 in the control group: less than 60 years of age). All patients underwent major surgery for head and neck cancer. Results: The median McPeek scores were 8 in the study group and 9 in the control group (p = 0.04). Regression analysis revealed that neither age (p = 0.085) nor the American Society of Anesthesiologists physical status score (p = 0.342) were independent predictors of the McPeek score. Synchronous surgical interventions (p = 0.00051) and duration of surgery (p = 0.0015) had a significant impact on McPeek score performance. Conclusions: The McPeek score seems to be an appropriate tool for comparing major surgeries for head and neck cancer in different age groups. It is possible to assess the influence of anesthetic and surgical interventions and complications that affect the length of hospitalization. The results confirm that the overall complication rate after surgery in elderly patients does not differ significantly from that in their younger counterparts. Therefore, extended surgical treatment should be offered to both age groups when no serious comorbidities are present. The postoperative outcome seems to depend on the duration and extent of the surgical intervention. C1 [Sesterhenn, Andreas M.; Schotte, Tobias L.; Wiegand, Susanne; Werner, Jochen A.] Univ Marburg, Dept Otolaryngol Head & Neck Surg, Marburg, Germany. [Bauhofer, Artur] Univ Marburg, Inst Theoret Surg, Marburg, Germany. [Timmesfeld, Nina] Univ Marburg, Inst Med Biometry & Epidemiol, Marburg, Germany. [Torossian, Alexander] Univ Marburg, Dept Anesthesiol & Crit Care, Marburg, Germany. [Ovassapian, Andranik] Univ Chicago, Dept Anesthesiol & Crit Care, Chicago, IL 60637 USA. RP Sesterhenn, AM (reprint author), Univ Hosp Marburg, Dept Otolaryngol Head & Neck Surg, Deutschhausstr 3, D-35037 Marburg, Germany. CR BARZAN L, 1990, J LARYNGOL OTOL, V104, P634, DOI 10.1017/S0022215100113453 Bauhofer A, 2006, LANGENBECK ARCH SURG, V391, P418, DOI 10.1007/s00423-005-0020-6 Beausang ES, 2003, HEAD NECK-J SCI SPEC, V25, P549, DOI 10.1002/hed.10240 Bhattacharyya N, 2003, LARYNGOSCOPE, V113, P368, DOI 10.1097/00005537-200302000-00030 Boruk M, 2005, ARCH OTOLARYNGOL, V131, P605, DOI 10.1001/archotol.131.7.605 Clayman GL, 1998, HEAD NECK-J SCI SPEC, V20, P216 Derks W, 2005, EUR ARCH OTO-RHINO-L, V262, P21, DOI 10.1007/s00405-004-0744-x Derks W, 2003, CLIN OTOLARYNGOL, V28, P399, DOI 10.1046/j.1365-2273.2003.00718.x Genden EM, 2005, J LARYNGOL OTOL, V119, P169 HARRIES M, 1989, J LARYNGOL OTOL, V103, P306, DOI 10.1017/S0022215100108771 KOCH WM, 1995, ARCH OTOLARYNGOL, V121, P262 KOWALSKI LP, 1994, AM J SURG, V168, P485, DOI 10.1016/S0002-9610(05)80107-2 Quer M, 1998, ANN OTO RHINOL LARYN, V107, P164 McPeek B, 1986, THEOR SURG, V1, P2 R Development Core Team, 2008, R LANG ENV STAT COMP Sanabria A, 2008, HEAD NECK-J SCI SPEC, V30, P170, DOI 10.1002/hed.20671 Sarini J, 2001, ARCH OTOLARYNGOL, V127, P1089 Shaari CM, 1998, ARCH OTOLARYNGOL, V124, P407 SHESTAK KC, 1992, HEAD NECK-J SCI SPEC, V14, P14, DOI 10.1002/hed.2880140104 Wolters U, 1996, BRIT J ANAESTH, V77, P217 NR 20 TC 5 Z9 5 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD FEB PY 2011 VL 120 IS 2 BP 110 EP 115 PG 6 WC Otorhinolaryngology SC Otorhinolaryngology GA 720JP UT WOS:000287277300007 PM 21391423 ER PT J AU Xu, W Hu, R Fan, EZ Han, DM AF Xu, Wen Hu, Rong Fan, Erzhong Han, Demin TI Adipose-Derived Mesenchymal Stem Cells in Collagen Hyaluronic Acid Gel Composite Scaffolds for Vocal Fold Regeneration SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE adipose-derived mesenchymal stem cell; extracellular matrix; regeneration; scaffold; vocal fold injury ID STROMAL CELLS; TISSUE; FIBROBLASTS; INJECTION; IMPLANTATION; THERAPY; SCAR AB Objectives: We sought to characterize the changes in the extracellular matrix (ECM) of the lamina propria following the implantation of autologous adipose-derived mesenchymal stem cells (ADSCs) in composite scaffolds in a rabbit vocal fold wound model. Methods: The ADSCs were co-cultured with collagen or hyaluronic acid gel. Each vocal fold was injured by localized resection and injected with ADSC complexes, ADSCs, or scaffolds or left untreated. From 15 days to 12 months, the vocal fold shape and the characteristics of the ECM components were analyzed. Results: With implantation of the ADSC complexes, the collagen content was significantly increased and had a disorderly distribution at 3 months. Subsequently, it began to decrease and reached close to normal by 12 months. The hyaluronic acid content was increased at 40 days, but it was reduced to normal levels and was limited to the superficial and middle layers of the lamina propria over the following 12 months. Fibronectin continued to be scattered in the lamina propria, at peak levels at 40 days, and then decreased over the following 12 months to reach near-normal levels. At 12 months, the vocal folds had a normal surface. Conclusions: ADSC complexes can play a facilitatory role in vocal fold regeneration, regulating the generation and orderly distribution of ECM. C1 [Han, Demin] Capital Med Univ, Beijing Tongren Hosp, Dept Otorhinolaryngol Head & Neck Surg, Beijing 100730, Peoples R China. Minist Educ, Key Lab Otorhinolaryngol Head & Neck Surg, Beijing, Peoples R China. RP Han, DM (reprint author), Capital Med Univ, Beijing Tongren Hosp, Dept Otorhinolaryngol Head & Neck Surg, 1 Dongjiao Minxiang, Beijing 100730, Peoples R China. FU National Natural Science Foundation of China [30973294]; Beijing Natural Science Foundation [7102031] FX Supported by Programs of the National Natural Science Foundation of China (30973294) and Programs of the Beijing Natural Science Foundation (7102031). CR BELL E, 1979, P NATL ACAD SCI USA, V76, P1274, DOI 10.1073/pnas.76.3.1274 Cedervall J, 2007, LARYNGOSCOPE, V117, P2075, DOI 10.1097/MLG.0b013e3181379c7c Chhetri DK, 2004, OTOLARYNG HEAD NECK, V131, P864, DOI 10.1016/j.otohns.2004.07.010 Dominici M, 2006, CYTOTHERAPY, V8, P315, DOI 10.1080/14653240600855905 Hahn MS, 2006, BIOMATERIALS, V27, P1104, DOI 10.1016/j.biomaterials.2005.07.022 Hertegard S, 2006, LARYNGOSCOPE, V116, P1248, DOI 10.1097/01.mlg.0000224548.68499.35 Johnson BQ, 2010, LARYNGOSCOPE, V120, P537, DOI 10.1002/lary.20782 Kanemaru S, 2005, ANN OTO RHINOL LARYN, V114, P907 Kanemaru SI, 2003, ANN OTO RHINOL LARYN, V112, P915 Kishirnoto Y, 2009, ANN OTO RHINOL LARYN, V118, P613 Krishna P, 2006, OTOLARYNG HEAD NECK, V135, P937, DOI 10.1016/j.otohns.2006.07.011 Lee BJ, 2006, CELLS TISSUES ORGANS, V184, P198, DOI 10.1159/000099627 Liu TM, 2007, STEM CELLS, V25, P750, DOI 10.1634/stemcells.2006-0394 Ohno S, 2009, ANN OTO RHINOL LARYN, V118, P805 Sahiner N, 2008, J BIOMAT SCI-POLYM E, V19, P223, DOI 10.1163/156856208783432462 Strem Brian M., 2005, Keio Journal of Medicine, V54, P132, DOI 10.2302/kjm.54.132 Svensson B, 2010, LARYNGOSCOPE, V120, P1370, DOI 10.1002/lary.20926 Thibeault SL, 2004, LARYNGOSCOPE, V114, P760, DOI 10.1097/00005537-200404000-00031 Wolchok JC, 2009, BIOMATERIALS, V30, P327, DOI 10.1016/j.biomaterials.2008.08.035 Zuk PA, 2001, TISSUE ENG, V7, P211, DOI 10.1089/107632701300062859 NR 20 TC 9 Z9 10 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD FEB PY 2011 VL 120 IS 2 BP 123 EP 130 PG 8 WC Otorhinolaryngology SC Otorhinolaryngology GA 720JP UT WOS:000287277300009 PM 21391425 ER PT J AU Lott, DG Russell, JO Khariwala, SS Dan, O Strome, M AF Lott, David G. Russell, Jonathon O. Khariwala, Samir S. Dan, Olivia Strome, Marshall TI Ten-Month Laryngeal Allograft Survival With Use of Pulsed Everolimus and Anti-alpha beta T-Cell Receptor Antibody Immunosuppression SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE alpha beta T-cell receptor; everolimus; immunosuppression; laryngeal transplantation ID RAT MODEL; IN-VIVO; TRANSPLANTATION; CANCER; INDUCTION; TOLERANCE; REJECTION; GROWTH AB Objectives: The risks of daily immunosuppression limit the use of laryngeal transplantation as a reconstructive option. Pulsed immunosuppressive dosing can lessen these risks. The study objective was to develop a long-term pulsing regimen that minimizes exposure to immunosuppressive agents. Methods: Rat laryngeal transplantation was performed. Everolimus (1 mg/kg per day) and anti-alpha beta T-cell receptor (TCR) antibodies (250 mu g) were given for 7 days beginning I day before transplantation and for 5 days beginning on day 90 after transplantation. On day 180, group I (n = 5) received the initial regimen for 3 days, and group 2 (n = 5) received everolimus (1 mg/kg per day) until euthanization, which occurred when parathyroid hormone (PTH) levels dropped to less than 11 pg/mL or at 300 days. Results: Four of the 5 rats in group I had normal PTH levels at 300 days. The PTH level for I rat was less than 11 pg/mL at 270 days. In group 2, none of the 5 rats had normal PTH levels at 300 days. Two had PTH levels below 11 pg/mL at 270 days, and 3 had PTH levels below 11 pg/mL at 300 days. The allografts that survived beyond 300 days had an essentially normal histologic appearance. Conclusions: Pulsed immunosuppression prevented allograft rejection for ID months and was more effective than daily everolimus. Short-term perioperative therapy followed by pulsed, tapered dosing is a viable alternative to traditional regimens and may decrease associated risks. C1 [Lott, David G.; Russell, Jonathon O.; Khariwala, Samir S.; Dan, Olivia; Strome, Marshall] Cleveland Clin, Head & Neck Inst, Cleveland, OH 44106 USA. RP Lott, DG (reprint author), Massachusetts Gen Hosp, Ctr Laryngeal Surg & Voice Rehabil, 1 Bowdoin Sq,11th Floor, Boston, MA 02114 USA. CR Akst LM, 2003, TRANSPLANTATION, V76, P1763, DOI 10.1097/01.TP.0000100398.39169.5B Birchall MA, 2006, AM J TRANSPLANT, V6, P20, DOI 10.1111/j.1600-6143.20005.01144.x Fernandez A, 2006, TRANSPLANT P, V38, P2453, DOI 10.1016/j.transproceed.2006.08.016 Genden EM, 2003, MT SINAI J MED, V70, P163 Khariwala SS, 2006, ANN OTO RHINOL LARYN, V115, P74 KHARIWALA SS, 2006, LARYNGOSCOPE, V116, P1302 Khariwala SS, 2006, LARYNGOSCOPE, V116, P814, DOI 10.1097/01.mlg.0000210544.64659.35 Kharlwala SS, 2008, AM J OTOLARYNG, V29, P242, DOI 10.1016/j.amjoto.2007.08.007 KINLEN LJ, 1985, AM J MED, V78, P44, DOI 10.1016/0002-9343(85)90245-1 Knott PD, 2008, AM J OTOLARYNG, V29, P398, DOI 10.1016/j.amjoto.2007.12.004 Knott PD, 2007, AM J OTOLARYNG, V28, P375, DOI 10.1016/j.amjoto.2006.11.003 Lorenz RR, 2002, ANN OTO RHINOL LARYN, V111, P1120 Lott DG, 2010, OTOLARYNG HEAD NECK, V142, P72, DOI 10.1016/j.otohns.2009.10.019 Mabuchi S, 2007, CLIN CANCER RES, V13, P4261, DOI 10.1158/1078-0432.CCR-06-2770 Nelson M, 2003, LARYNGOSCOPE, V113, P1483, DOI 10.1097/00005537-200309000-00011 Nelson M, 2003, LARYNGOSCOPE, V113, P1308, DOI 10.1097/00005537-200308000-00009 Penn I, 1998, Clin Transpl, P147 Potter CPS, 1998, TRANSPL INT, V11, P433 Scharpf J, 2006, MICROSURG, V26, P599, DOI 10.1002/micr.20294 Schuler W, 1997, TRANSPLANTATION, V64, P36, DOI 10.1097/00007890-199707150-00008 Shipchandler TZ, 2008, LARYNGOSCOPE, V118, P2166, DOI 10.1097/MLG.0b013e3181855108 Siemionow MZ, 2003, TRANSPLANTATION, V76, P1662, DOI 10.1097/01.TP.0000105343.49626.6F Strome M, 2001, NEW ENGL J MED, V344, P1676, DOI 10.1056/NEJM200105313442204 NR 23 TC 2 Z9 2 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD FEB PY 2011 VL 120 IS 2 BP 131 EP 136 PG 6 WC Otorhinolaryngology SC Otorhinolaryngology GA 720JP UT WOS:000287277300010 PM 21391426 ER PT J AU Chernichenko, N Woo, JS Hundal, JS Sasaki, CT AF Chernichenko, Natalya Woo, Jeong-Soo Hundal, Jagdeep S. Sasaki, Clarence T. TI Response of Cricopharyngeus Muscle to Esophageal Stimulation by Mechanical Distension and Acid and Bile Perfusion SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE bile acid; cricopharyngeus; gastroesophageal reflux ID GASTROESOPHAGEAL-REFLUX DISEASE; SPHINCTER; INNERVATION; DISTENTION; MODEL AB Objectives: The aim of this study was to identify the response of the cricopharyngeus muscle (CPM) to esophageal stimulation by intraluminal mechanical distension and intraluminal acid and bile perfusion. Methods: In 3 adult pigs, electromyographic (EMG) activity of the CPM was recorded at baseline and after esophageal stimulation at 3 levels: proximal, middle, and distal. The esophagus was stimulated with 20-mL balloon distension and intraluminal perfusion of 40 mL 0.1N hydrochloric acid, taurocholic acid (pH 1.5), and chenodeoxycholic acid (pH 7.4) at the rate of 40 mL/min. The EMG spike density was defined as peak-to-peak spikes greater than 10 mu V averaged over 10-ms intervals. Results: In all 3 animals, the spike density at baseline was 0. The spike densities increased after proximal and middle distensions to 15.2 +/- 1.5 and 5.1 +/- 1.2 spikes per 10 ms, respectively. No change in CPM EMG activity occurred after distal distension. The spike density following intraluminal perfusion with hydrochloric acid at the distal level was 10.1 +/- 1.1 spikes per 10 ms. No significant change in CPM EMG activity occurred after acid perfusion at the middle and proximal levels. No change in CPM EMG activity occurred after intraluminal esophageal perfusion with either taurocholic acid or chenodeoxycholic acid. Conclusions: Proximal esophageal distension, as well as distal intraluminal acid perfusion, appeared to be important mechanisms in generation of CPM activity. Bile acids, on the other hand, failed to evoke such CPM activity. The data suggest that transpyloric refluxate may not be significant enough to evoke the CPM protective sphincteric function, thereby placing supraesophageal structures at risk of bile injury. C1 [Chernichenko, Natalya; Woo, Jeong-Soo; Hundal, Jagdeep S.; Sasaki, Clarence T.] Yale Univ, Sch Med, Sect Otolaryngol Head & Neck Surg, New Haven, CT 06520 USA. RP Sasaki, CT (reprint author), Yale Univ, Sch Med, Sect Otolaryngol Head & Neck Surg, 333 Cedar St,POB 208041, New Haven, CT 06520 USA. CR BELSEY R, 1966, J THORAC CARDIOV SUR, V52, P164 CREAMER B, 1957, J APPL PHYSIOL, V10, P498 ENZMANN DR, 1977, GASTROENTEROLOGY, V72, P1292 GERHARDT DC, 1978, GASTROENTEROLOGY, V75, P268 HUNT PS, 1970, GUT, V11, P303, DOI 10.1136/gut.11.4.303 KOUFMAN JA, 1991, LARYNGOSCOPE, V101, P1 Lang IM, 2001, AM J PHYSIOL-GASTR L, V281, pG1246 LANG IM, 1991, AM J PHYSIOL, V260, pG911 NEUHUBER WL, 1987, J AUTONOM NERV SYST, V20, P243, DOI 10.1016/0165-1838(87)90153-6 Orlando RC, 2006, DRUGS S1, V66, P29 Orlando RC, 2006, DRUGS, V66, P1 Perera L, 2008, AM J PHYSIOL-GASTR L, V294, pG885, DOI 10.1152/ajpgi.00470.2007 Sasaki CT, 2005, ANN OTO RHINOL LARYN, V114, P192 Sasaki CT, 1999, ANN OTO RHINOL LARYN, V108, P1132 Schopf BW, 1997, J INVEST SURG, V10, P105, DOI 10.3109/08941939709032140 SCHWEITZER EJ, 1986, DIGEST DIS SCI, V31, P1105, DOI 10.1007/BF01300265 SHAKER R, 1994, AM J PHYSIOL, V266, pG147 Singh S, 2005, NEUROGASTROENT MOTIL, V17, P773 Sivarao D. V., 2000, American Journal of Medicine, V108, p27S Szczesniak MM, 2008, AM J PHYSIOL-GASTR L, V294, pG982, DOI 10.1152/ajpgi.00496.2007 THOMPSON DG, 1988, GUT, V29, P881, DOI 10.1136/gut.29.7.881 WALLIN L, 1978, SCAND J GASTROENTERO, V13, P821 NR 22 TC 1 Z9 2 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD FEB PY 2011 VL 120 IS 2 BP 137 EP 142 PG 6 WC Otorhinolaryngology SC Otorhinolaryngology GA 720JP UT WOS:000287277300011 PM 21391427 ER PT J AU Roy, N Smith, ME Houtz, DR AF Roy, Nelson Smith, Marshall E. Houtz, Daniel R. TI Laryngeal Features of External Superior Laryngeal Nerve Denervation: Revisiting a Century-Old Controversy SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE denervation; epiglottic petiole deviation; superior laryngeal nerve ID CRICOTHYROID MUSCLE; PARALYSIS; PARESIS; PHONATION; FREQUENCY; BELLIES AB A long-standing controversy exists regarding the laryngoscopic features associated with unilateral denervation of the external superior laryngeal nerve (ESLN). Recently, we modeled acute unilateral cricothyroid muscle paralysis by blocking the ipsilateral ESLN with lidocaine hydrochloride, and identified epiglottic petiole deviation to the side of paralysis during high-pitched voice production as a possible diagnostic sign. This study provides preliminary clinical evidence supporting the presence of petiole deviation in cases of ESLN denervation. Epiglottic petiole deviation to the side of weakness was present in electromyographically confirmed cases of unilateral partial or complete ESLN denervation, in isolation or in combination with denervation of other branches of the vagus nerve. In addition, a case of complete ESLN and recurrent laryngeal nerve (RLN) denervation showed return of the petiole to the midline 6 months after surgical reinnervation of the ESLN and RLN. Finally, petiole deviation was not present in isolated RLN paralysis a finding suggesting that the diagnostic sign is uniquely associated with ESLN denervation. We concluded that deviation of the petiole to the side of cricothyroid muscle weakness during high-pitched voice production represents a potential diagnostic sign of unilateral ESLN denervation. Further research is necessary to determine factors that influence the expression and detection of this sign, as well as its diagnostic precision. C1 [Roy, Nelson] Univ Utah, Dept Commun Sci & Disorders, Salt Lake City, UT 84112 USA. [Smith, Marshall E.] Univ Utah, Div Otolaryngol Head & Neck Surg, Salt Lake City, UT 84112 USA. [Houtz, Daniel R.] Univ Utah, Voice Disorders Ctr, Salt Lake City, UT 84112 USA. RP Roy, N (reprint author), Univ Utah, Dept Commun Sci & Disorders, 390 South 1530 East,Room 1219, Salt Lake City, UT 84112 USA. CR ABELSON TI, 1981, OTOLARYNG HEAD NECK, V89, P463 ADOUR KK, 1980, OTOLARYNG HEAD NECK, V88, P418 ARNOLD GF, 1961, LARYNGOSCOPE, V1, P687 ATKINSON JE, 1978, J ACOUST SOC AM, V63, P211, DOI 10.1121/1.381716 DEDO HH, 1970, LARYNGOSCOPE, V80, P1455, DOI 10.1288/00005537-197010000-00001 Dursun G, 1996, J VOICE, V10, P206, DOI 10.1016/S0892-1997(96)80048-8 Eckley CA, 1998, J VOICE, V12, P340, DOI 10.1016/S0892-1997(98)80024-6 FAABORG-ANDERSEN K, 1964, Acta Otolaryngol, V57, P155, DOI 10.3109/00016486409136955 FAABORGANDERSEN K, 1957, ACTA PHYSL SCAND, V41, P140 GAY T, 1972, ANN OTO RHINOL LARYN, V81, P401 Heman-Ackah YD, 2003, J VOICE, V17, P579, DOI 10.1016/S0892-1997(03)00085-7 Heman-Ackah Yolanda D, 2006, J Voice, V20, P269, DOI 10.1016/j.jvoice.2005.03.010 HIRANO M, 1969, J SPEECH HEAR RES, V12, P616 Hong KH, 1998, OTOLARYNG HEAD NECK, V118, P714, DOI 10.1177/019459989811800530 Mu LC, 2009, J VOICE, V23, P21, DOI 10.1016/j.jvoice.2007.08.001 MYGIND H, 1906, ARCH LARYNGOL RHINOL, V18, P403 New GB, 1930, J OTOLARYNGOL, V11, P752 Roy N, 2009, LARYNGOSCOPE, V119, P1017, DOI 10.1002/lary.20193 Rubin AD, 2005, J VOICE, V19, P679, DOI 10.1016/j.jvoice.2004.11.001 Sulica L, 2004, OTOLARYNG CLIN N AM, V37, pXI, DOI 10.1016/S0030-6665(03)00178-6 TANAKA S, 1994, ANN OTO RHINOL LARYN, V103, P93 Titze IR, 1994, PRINCIPLES VOICE PRO WARD PH, 1977, T AM ACAD OPHTHALMOL, V84, P78 NR 23 TC 4 Z9 4 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD JAN PY 2011 VL 120 IS 1 BP 1 EP 8 PG 8 WC Otorhinolaryngology SC Otorhinolaryngology GA 712DS UT WOS:000286645500001 PM 21370674 ER PT J AU Berrettini, S Bruschini, L Stefanini, C D'Alessandro, D D'Acunto, M Danti, S AF Berrettini, Stefano Bruschini, Luca Stefanini, Cesare D'Alessandro, Delfo D'Acunto, Mario Danti, Serena TI Good Manufacturing Practices-Grade Preformed Ossicular Prostheses From Banked Bone Via Computer Numerically Controlled Micromilling SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE banked bone; homograft; micromilling; ossicular replacement prosthesis; ossiculoplasty ID OSSICULOPLASTY; SURGERY; RECONSTRUCTION; CARTILAGE; OSSICLES AB Objectives: The aim of this study was the fabrication of ossicular replacement prostheses (ORPs) from decellularized banked cortical bone via computer numerically controlled (CNC) ultraprecision micromilling, in order to obtain preformed clinical-grade tissue products, reproducing shape, size, and details perfectly comparable to those of synthetic devices. Methods: Banked femoral compact bone was used to fabricate partial and total ORPs via CNC micromilling according to Good Manufacturing Practices procedures. Drawings of ORPs with different shapes and sizes were uploaded to the computer interface, and different surface-finish parameters were tested. The obtained products underwent dimensional, weight, and surface characterizations. A histologic analysis was pursued to compare the bone matrix compactness of the produced ORPs to that of the ear ossicles. Results: Banked-bone ORPs were produced with high dimensional accuracy. Partial ORP weights averaged (+/- SD) 31.2 +/- 0.6 mg, and total ORP weights averaged 69.3 +/- 0.7 mg. The best-finish mode allowed microscale or nanoscale roughness free from machinery textures to be obtained. Finally, the histologic analysis confirmed that the extracellular matrix compactness of the produced ORPs was suitable for ossicular chain replacement. Conclusions: This study assesses the fabrication feasibility of novel banked-bone ORPs of extremely high dimensional accuracy. Such devices are aimed at combining the most favorable aspects of both synthetic (reproducibility, convenience, and biosafety) and biological replacements (total biocompatibility). C1 [Berrettini, Stefano; Bruschini, Luca; D'Alessandro, Delfo; Danti, Serena] Univ Pisa, Dept Neurosci, Otol Cochlear Implants Unit, I-56124 Pisa, Italy. [D'Alessandro, Delfo; Danti, Serena] Univ Pisa, CUCCS RRMR, I-56124 Pisa, Italy. [Stefanini, Cesare] Scuola Super Sant Anna, Ctr Res Microengn, I-56124 Pisa, Italy. [D'Acunto, Mario] CNR, ISTI, Pisa, Italy. RP Berrettini, S (reprint author), Univ Pisa, Azienda Osped, SOD Otol & Impianti Cocleari, Via Paradisa 2, I-56124 Pisa, Italy. CR Bahmad F, 2007, ANN OTO RHINOL LARYN, V116, P181 Beutner D, 2009, Laryngorhinootologie, V88 Suppl 1, pS32, DOI 10.1055/s-0028-1119493 Bruschini P, 1992, Acta Otorhinolaryngol Ital, V12, P443 Bruschini P, 1991, Acta Otorhinolaryngol Ital, V11, P159 Danti S, 2009, BIOMED MICRODEVICES, V11, P783, DOI 10.1007/s10544-009-9293-9 Ferrero V, 2000, Acta Otorhinolaryngol Ital, V20, P159 Giannoudis PV, 2005, INJURY, V36, P20, DOI 10.1016/j.injury.2005.07.029 HOUSE WF, 1966, ARCHIV OTOLARYNGOL, V84, P148 Lubbe D, 2008, J LARYNGOL OTOL, V122, P111, DOI 10.1017/S0022215107000795 McGee M, 1999, OTOLARYNG CLIN N AM, V32, P471, DOI 10.1016/S0030-6665(05)70146-8 Merchant SN, 1998, J LARYNGOL OTOL, V112, P715 Needham AJ, 2005, OTOL NEUROTOL, V26, P218, DOI 10.1097/00129492-200503000-00015 Nguyen D Q, 2004, Rev Laryngol Otol Rhinol (Bord), V125, P157 Quaranta N, 2001, EUR ARCH OTO-RHINO-L, V258, P20, DOI 10.1007/s004050000300 ROSOWSKI JJ, 1995, AM J OTOL, V16, P486 SELLARIFRANCESCHINI S, 1987, AM J OTOL, V8, P551 Kobayashi T, 2002, AM J OTOLARYNG, V23, P222, DOI 10.1053/ajot.2002.124191 VANBLITTERSWIJK CA, 1990, ANN OTO RHINOL LARYN, V99, P3 Wullstein HL, 1952, ARCH OHR NAS KEHLKOP, V161, P422, DOI 10.1007/BF02129204 Yung MW, 2003, J LARYNGOL OTOL, V117, P431 NR 20 TC 3 Z9 3 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD JAN PY 2011 VL 120 IS 1 BP 9 EP 16 PG 8 WC Otorhinolaryngology SC Otorhinolaryngology GA 712DS UT WOS:000286645500002 PM 21370675 ER PT J AU Maturo, S Tse, SM Kinane, TB Hartnick, CJ AF Maturo, Stephen Tse, Sze Man Kinane, T. Bernard Hartnick, Christopher J. TI Initial Experience Using Propranolol as an Adjunctive Treatment in Children With Aggressive Recurrent Respiratory Papillomatosis SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE papilloma; pediatric airway; propranolol ID INTRALESIONAL CIDOFOVIR; BETA-BLOCKERS; HEMANGIOMAS; GROWTH; SAFETY; INDOLE-3-CARBINOL; INJECTIONS; CARCINOMA; INFANCY; ASTHMA AB We performed a retrospective chart review with a 6-month follow-up to examine the initial use of propranolol as an adjunctive treatment in children with severe recurrent respiratory papillomatosis. This is the first such report. Two of 3 children with severe recurrent respiratory papillomatosis demonstrated a response to oral propranolol therapy, as evidenced by an improved voice and by an increased time between surgical interventions. One child demonstrated no response to propranolol, and medication was halted. Both children who demonstrated a response had undergone more than 10 surgical interventions in the previous year, along with prior treatment including surgical excision and adjuvant therapy. Both children more than doubled the interval between treatments after propranolol administration, and the parents of both children noted marked improvement of the child's voice as measured by their Pediatric Voice-Related Quality of Life score (from 40 to 67.5 in one child and from 27 to 60 in the other child). No child experienced hypoglycemia or blood pressure abnormalities. We conclude that initial use of propranolol as an adjunctive measure in severe recurrent respiratory papillomatosis shows it to have some efficacy in delaying surgical intervention and improving voice. Previous reports have demonstrated relatively safe use of propranolol in children with hemangiomas. Further studies are needed to determine the long-term effectiveness, dosing strategies, and side-effect profile of propranolol for treatment of recurrent respiratory papillomatosis C1 [Maturo, Stephen; Hartnick, Christopher J.] Massachusetts Eye & Ear Infirm, Dept Otolaryngol, Boston, MA 02114 USA. [Tse, Sze Man; Kinane, T. Bernard] Massachusetts Gen Hosp Children, Dept Pulm Med, Boston, MA USA. RP Maturo, S (reprint author), Massachusetts Eye & Ear Infirm, Dept Otolaryngol, 243 Charles St, Boston, MA 02114 USA. CR Annabi B, 2009, PHARMACOL RES, V60, P438, DOI 10.1016/j.phrs.2009.05.005 ARTMAN M, 1982, PEDIATRICS, V70, P30 Batisky DL, 2007, J PEDIATR-US, V150, P134, DOI 10.1016/j.jpeds.2006.09.031 Buckmiller L, 2009, LARYNGOSCOPE, V119, P2051, DOI 10.1002/lary.20633 Chadha NK, 2007, OTOLARYNG HEAD NECK, V136, P863, DOI 10.1016/j.otohns.2006.09.007 Denoyelle F, 2009, INT J PEDIATR OTORHI, V73, P1168, DOI 10.1016/j.ijporl.2009.04.025 Derkay CS, 2008, LARYNGOSCOPE, V118, P1236, DOI 10.1097/MLG.0b013e31816a7135 Guo K, 2009, ONCOL REP, V22, P825, DOI 10.3892/or_00000505 Hanania NA, 2008, PULM PHARMACOL THER, V21, P134, DOI 10.1016/j.pupt.2007.07.002 Hlushchuk R, 2007, MICROCIRCULATION, V14, P813, DOI 10.1080/10739680701370021 Leaute-Labreze C, 2008, NEW ENGL J MED, V358, P2649, DOI 10.1056/NEJMc0708819 Lee JW, 2009, CLIN CANCER RES, V15, P2695, DOI 10.1158/1078-0432.CCR-08-2966 Lipworth BJ, 2010, CLIN SCI, V118, P115, DOI 10.1042/CS20090398 Lopez-Ocejo O, 2000, ONCOGENE, V19, P4611, DOI 10.1038/sj.onc.1203817 Lott DG, 2009, LARYNGOSCOPE, V119, P567, DOI 10.1002/lary.20082 Pransky SM, 2000, ARCH OTOLARYNGOL, V126, P1239 Pransky SM, 1999, ARCH OTOLARYNGOL, V125, P1143 Rahbar R, 2005, ANN OTO RHINOL LARYN, V114, P289 Reeves WC, 2003, ARCH OTOLARYNGOL, V129, P976, DOI 10.1001/archotol.129.9.976 Rosen CA, 1998, OTOLARYNG HEAD NECK, V118, P810, DOI 10.1016/S0194-5998(98)70274-8 Rosen CA, 2004, J VOICE, V18, P248, DOI 10.1016/j.jvoice.2003.05.005 Siegfried EC, 2008, NEW ENGL J MED, V359, P2846, DOI 10.1056/NEJMc086443 Snoeck R, 1998, J MED VIROL, V54, P219, DOI 10.1002/(SICI)1096-9071(199803)54:3<219::AID-JMV13>3.0.CO;2-C Theletsane T, 2009, J EUR ACAD DERMATOL, V23, P1465, DOI 10.1111/j.1468-3083.2009.03261.x van der Woude HJ, 2005, CHEST, V127, P818, DOI 10.1378/chest.127.3.818 Wemer RD, 2005, ANN OTO RHINOL LARYN, V114, P836 NR 26 TC 5 Z9 5 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD JAN PY 2011 VL 120 IS 1 BP 17 EP 20 PG 4 WC Otorhinolaryngology SC Otorhinolaryngology GA 712DS UT WOS:000286645500003 PM 21370676 ER PT J AU Patel, RR Liu, L Galatsanos, N Bless, DM AF Patel, Rita R. Liu, Li Galatsanos, Nikolaos Bless, Diane M. TI Differential Vibratory Characteristics of Adductor Spasmodic Dysphonia and Muscle Tension Dysphonia on High-Speed Digital Imaging SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE high-speed digital imaging; muscle tension dysphonia; spasmodic dysphonia; vocal fold motion; voice analysis ID FINE-WIRE ELECTROMYOGRAPHY; BOTULINUM TOXIN THERAPY; LARYNGEAL DYSTONIA; FIBEROPTIC LARYNGOSCOPY; DIAGNOSIS; VOICE; NEUROLARYNGOLOGY; STROBOSCOPY; MANAGEMENT; DISORDERS AB Objectives: The purpose of this study was to quantify disorder-specific signature kinematic disturbances of vibratory motion in adductor spasmodic dysphonia (AdSD) and muscle tension dysphonia (MTD), in voice disturbances of a severe nature, with the use of high-speed digital imaging (HSDI). A secondary hypothesis of the study was to investigate the sensitivity and specificity of the signature kinematic features obtained from HSDI, in differentiating between AdSD and MTD. Methods: We used vibratory features from automated extraction of vocal fold motion waveforms and glottal cycle montage analysis from HSDI for differential kinematic profiling of AdSD and MTD. Results: Novel features of motion irregularities and micromotions (as small as 27 ms) were greater in number for AdSD, whereas reduced motion irregularities, absence of oscillatory breaks, absence of micromotions, and increased hyperfunction characterized the MTD group. Oscillatory breaks (as small as 8 ms), although present only in the AdSD group, were not statistically significant because of their reduced number of occurrences compared to the other features. Further montage analysis of successive glottal cycles of oscillatory breaks in the AdSD group revealed 3 different kinematic patterns within the AdSD group, indicative of likely AdSD with: 1) possible predominant thyroarytenoid muscle involvement, 2) possible predominant cricothyroid muscle involvement, and 3) possible combined involvements of the thyroarytenoid and lateral cricoarytenoid muscles. Four consistent but unique kinematic patterns were identified within the MTD group: 1) diplophonia, 2) vocal fry, 3) breathy phonation, and 4) pressed phonation. Sensitivity and specificity analysis revealed that only motion irregularity was a significant predictor of the presence of AdSD. Conclusions: Fine kinematic analysis from HSDI can be used to aid detailed clinical profiling of the source characteristics of AdSD and MTD. C1 [Patel, Rita R.; Bless, Diane M.] Univ Wisconsin Madison, Dept Surg, Div Otolaryngol Head & Neck Surg, Madison, WI USA. [Liu, Li; Galatsanos, Nikolaos] IIT, Chicago, IL 60616 USA. RP Patel, RR (reprint author), Univ Kentucky, 900 S Limestone,120D,Charles T Wethington Bldg, Lexington, KY 40536 USA. CR Adams SG, 1996, LARYNGOSCOPE, V106, P296, DOI 10.1097/00005537-199603000-00010 Aronson AE, 1990, CLIN VOICE DISORDERS BARKMEIER JM, 2000, CURR OPIN OTOLARYNGO, V8, P174, DOI 10.1097/00020840-200006000-00008 Barkmeier JM, 2001, J COMMUN DISORD, V34, P21, DOI 10.1016/S0021-9924(00)00039-3 Blitzer A, 1998, LARYNGOSCOPE, V108, P1435, DOI 10.1097/00005537-199810000-00003 BLITZER A, 1991, ANN OTO RHINOL LARYN, V100, P85 Cantarella G, 2006, OTOLARYNG HEAD NECK, V134, P419, DOI 10.1016/j.otohns.2005.10.028 Carding PN, 2004, CLIN OTOLARYNGOL, V29, P538, DOI 10.1111/j.1365-2273.2004.00846.x Colton RH, 1996, UNDERSTANDING VOICE Eysholdt U, 1996, FOLIA PHONIATR LOGO, V48, P163 Ford CE, 1998, ARCH OTOLARYNGOL, V124, P476 FORD CN, 1990, OTOLARYNG HEAD NECK, V103, P752 Hertegård Stellan, 2005, Curr Opin Otolaryngol Head Neck Surg, V13, P152, DOI 10.1097/01.moo.0000163451.98079.ba Hertegård Stellan, 2003, Logoped Phoniatr Vocol, V28, P133, DOI 10.1080/14015430310015246 Higgins MB, 1999, J SPEECH LANG HEAR R, V42, P101 Hillel AD, 2001, LARYNGOSCOPE, V111, P1, DOI 10.1097/00005537-200104001-00001 Hirano M, 1981, CLIN EXAMINATION VOI Imamura Rui, 2006, Braz J Otorhinolaryngol, V72, P434 IZDEBSKI C, 1984, ACTA OTO-LARYNGOL, V97, P373 KIRITANI S, 1993, SPEECH COMMUN, V13, P23, DOI 10.1016/0167-6393(93)90056-Q Klotz DA, 2004, ANN OTO RHINOL LARYN, V113, P602 Kreiman J, 2005, J ACOUST SOC AM, V117, P2201, DOI 10.1121/1.1858351 Leonard R, 1999, LARYNGOSCOPE, V109, P295, DOI 10.1097/00005537-199902000-00022 Lin E, 2000, J VOICE, V14, P8, DOI 10.1016/S0892-1997(00)80090-9 LUDLOW CL, 1995, ANN OTO RHINOL LARYN, V104, P928 LUDLOW CL, 1987, J SPEECH HEAR RES, V30, P197 Merati AL, 2005, OTOLARYNG HEAD NECK, V133, P654, DOI 10.1016/j.otohns.2005.05.003 MOORE P, 1958, FOLIA PHONIATR, V10, P205 MORRISON MD, 1986, LARYNGOSCOPE, V96, P1 MORRISON MD, 1983, J OTOLARYNGOL, V12, P302 Nash EA, 1996, LARYNGOSCOPE, V106, P484, DOI 10.1097/00005537-199604000-00017 Olthoff A, 2007, LARYNGOSCOPE, V117, P1123, DOI 10.1097/MLG.0b013e318041f70c PARNES SM, 1978, ANN OTO RHINOL LARYN, V87, P322 Patel R, 2008, ANN OTO RHINOL LARYN, V117, P413 Roy N, 2008, LARYNGOSCOPE, V118, P2245, DOI 10.1097/MLG.0b013e318184577c Roy N, 2005, LARYNGOSCOPE, V115, P311, DOI 10.1097/01.mlg.0000154739.48314.ee Roy Nelson, 2003, Curr Opin Otolaryngol Head Neck Surg, V11, P144, DOI 10.1097/00020840-200306000-00002 Roy N, 2007, FOLIA PHONIATR LOGO, V59, P83, DOI 10.1159/000098341 Roy N, 1996, ANN OTO RHINOL LARYN, V105, P851 Sapienza CM, 1999, J SPEECH LANG HEAR R, V42, P127 Sapienza CM, 1998, J VOICE, V12, P214, DOI 10.1016/S0892-1997(98)80041-6 Sapienza CM, 2000, J VOICE, V14, P502, DOI 10.1016/S0892-1997(00)80008-9 Titze IR, 1995, WORKSH AC VOIC AN SU Wittenberg T, 2000, J VOICE, V14, P422, DOI 10.1016/S0892-1997(00)80087-9 WOO P, 1992, J VOICE, V6, P344, DOI 10.1016/S0892-1997(05)80031-1 WOODSON GE, 1991, J VOICE, V5, P85, DOI 10.1016/S0892-1997(05)80168-7 WOODSON GE, 1992, J VOICE, V6, P338, DOI 10.1016/S0892-1997(05)80030-X ZWIRNER P, 1992, LARYNGOSCOPE, V102, P400, DOI 10.1288/00005537-199204000-00006 NR 48 TC 6 Z9 7 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD JAN PY 2011 VL 120 IS 1 BP 21 EP 32 PG 12 WC Otorhinolaryngology SC Otorhinolaryngology GA 712DS UT WOS:000286645500004 PM 21370677 ER PT J AU Ho, AS Morzaria, S Damrose, EJ AF Ho, Allen S. Morzaria, Sanjay Damrose, Edward J. TI Carbon Dioxide Laser-Assisted Endoscopic Cricopharyngeal Myotomy With Primary Mucosal Closure SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE buccopharyngeal fascia; cricopharyngeal dysfunction; cricopharyngeus muscle; dysphagia; endoscopic cricopharyngeal myotomy; laser ID OROPHARYNGEAL DYSPHAGIA; ZENKERS DIVERTICULUM; SURGERY; DYSMOTILITY; DYSFUNCTION; MANAGEMENT; NECK; HEAD; BAR AB Objectives: Carbon dioxide laser assisted endoscopic cricopharyngeal myotomy (ECPM) has emerged as a viable therapy for dysphagia. The risks of the procedure include pharyngoesophageal perforation and mediastinitis, which may discourage adoption of this technique. To address these complications, we examined outcomes of ECPM with primary mucosal closure. Methods: A case series of 7 patients who underwent ECPM between 2006 and 2008 were reviewed for length of operation, length of hospitalization, postoperative complications, and outcomes by use of the M. D. Anderson Dysphagia Index (MDADI) and the Functional Outcome Swallowing Scale (FOSS). The results were compared to those of a control group of 7 patients treated during the same period via open cricopharyngeal myotomy. Results: All patients who had ECPM were treated successfully without complications. The operative times averaged 128 minutes. The hospitalization averaged 2.1 days. Statistically significant improvements in swallowing were seen (MDADI score from 51.3 to 77.7, p <0.0006; FOSS score from 3.7 to 1.3, p <0.0005), and were similar to those in the patients who had the open procedure (FOSS score from 3.0 to 1.0, p <0.006). Trends toward decreased blood loss, a shorter hospital stay, and a lower complication rate were observed in the patients who had ECPM. Conclusions: ECPM is beneficial as a primary treatment for cricopharyngeal dysfunction. Closure of the mucosal defect may help reduce the incidence of postoperative cervical emphysema and mediastinitis, and does not appear to compromise functional outcome. C1 [Ho, Allen S.; Morzaria, Sanjay; Damrose, Edward J.] Stanford Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, Div Laryngol, Stanford, CA 94305 USA. RP Damrose, EJ (reprint author), Stanford Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, Div Laryngol, 801 Welch Rd, Stanford, CA 94305 USA. EM edamrose@ohns.stanford.edu CR Brouillette D, 1997, Chest Surg Clin N Am, V7, P457 Bastian RW, 2001, ARCH OTOLARYNGOL, V127, P691 Belafsky Peter C, 2003, Ear Nose Throat J, V82, P755 Brigand C, 2007, BRIT J SURG, V94, P978, DOI 10.1002/bjs.5760 Brondbo K, 2000, ACTA OTO-LARYNGOL, P222 Chang CWD, 2005, ANN OTO RHINOL LARYN, V114, P897 Chen AY, 2001, ARCH OTOLARYNGOL, V127, P870 Dauer E, 2006, OTOLARYNG HEAD NECK, V134, P830, DOI 10.1016/j.otohns.2005.12.030 DEDO H, 1990, SURG LARYNX TRACHEA, P95 Frederick MG, 1996, AM J ROENTGENOL, V166, P353 Goyal Raj K., 1993, Dysphagia, V8, P252, DOI 10.1007/BF01354547 Grodinsky M, 1938, AM J ANAT, V63, P367, DOI 10.1002/aja.1000630303 HALVORSON DJ, 1994, ANN OTO RHINOL LARYN, V103, P173 Halvorson DJ, 1998, ENDOSCOPY, V30, P46, DOI 10.1055/s-2007-993729 HERBERHOLD C, 1995, ADV OTO-RHINO-LARYNG, V49, P144 Hino M, 2000, BRIT J HAEMATOL, V108, P194, DOI 10.1046/j.1365-2141.2000.01818.x Hoffman M, 2003, ANN OTO RHINOL LARYN, V112, P202 KAPLAN S, 1951, ANN SURG, V133, P572, DOI 10.1097/00000658-195113340-00021 Kelly James H., 2000, American Journal of Medicine, V108, p43S Lawson G, 2003, EUR ARCH OTO-RHINO-L, V260, P475, DOI 10.1007/s00405-003-0605-z Lim R Y, 1995, J Clin Laser Med Surg, V13, P241 LINDGREN S, 1990, CLIN OTOLARYNGOL, V15, P221, DOI 10.1111/j.1365-2273.1990.tb00779.x MacGillivray TE, 2003, J CARDIAC SURG, V18, P480, DOI 10.1046/j.0886-0440.2003.02073.x MCKENNA JA, 1992, ANN OTO RHINOL LARYN, V101, P216 MITSUHATA H, 1994, ANESTHESIOLOGY, V81, P1074, DOI 10.1097/00000542-199410000-00034 Mortensen M, 2010, LARYNGOSCOPE, V120, P17, DOI 10.1002/lary.20657 Ozgursoy OB, 2010, OTOLARYNG HEAD NECK, V142, P735, DOI 10.1016/j.otohns.2009.08.020 Pitman M, 2009, LARYNGOSCOPE, V119, P45, DOI 10.1002/lary.20032 ROSS ER, 1982, OTOLARYNG HEAD NECK, V90, P434 Salassa JR, 1999, DIGEST DIS, V17, P230, DOI 10.1159/000016941 Takes RP, 2005, HEAD NECK-J SCI SPEC, V27, P703, DOI 10.1002/hed.20201 van Overbeek JJM, 2003, ANN OTO RHINOL LARYN, V112, P583 Wang AY, 2005, GASTROINTEST ENDOSC, V61, P148, DOI 10.1016/S0016-5107(04)02447-2 Zaninotto G, 2004, J GASTROINTEST SURG, V8, P997, DOI 10.1016/j.gassur.2004.09.037 NR 34 TC 5 Z9 5 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD JAN PY 2011 VL 120 IS 1 BP 33 EP 39 PG 7 WC Otorhinolaryngology SC Otorhinolaryngology GA 712DS UT WOS:000286645500005 PM 21370678 ER PT J AU McMahon, JT Aslam, R Schell, SE AF McMahon, James T. Aslam, Rizwan Schell, Stephen E. TI Unusual Ciliary Abnormalities in Three 9/11 Response Workers SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE 9/11; abnormal cilia; environmental pollution; World Trade Center ID WORLD-TRADE-CENTER; CENTER DISASTER SITE; LUNG-FUNCTION; GENETIC SUSCEPTIBILITY; RESPIRATORY CILIA; NASAL EPITHELIUM; BEAT FREQUENCY; FIREFIGHTERS; SYMPTOMS; DECLINE AB After the 9/11 terrorist attacks on the World Trade Center in New York in 2001, thousands of response workers were exposed to complex mixtures of toxins, pollutants, and carcinogens. Many developed illnesses involving the respiratory tract. We report unusual ultrastructural ciliary abnormalities in 3 response workers that corresponded to their respiratory and ciliary functional abnormalities. Each patient had respiratory cilia biopsies that were evaluated for motility and ultrastructural changes. Impaired ciliary motility was seen in 2 of the 3 patients. Each of the patients showed monomorphic ultrastructural abnormalities. Two of the patients showed identical triangular disarray of axonemal microtubules with peripheral doublets 1, 4, and 7 forming the corners of the triangle and doublet 9 always more medially displaced than doublets 2, 3, 5, 6, and 8. Two workers had cilia in which axonemes were replaced by homogeneously dense cores. One of these also had cilia with triangular axonemes as previously described. The other had cilia with a geometric triangular to pentagonal shape. The ciliary abnormalities described here may represent a new class of primary ciliary dyskinesia in which abnormalities may have a genetic basis and a phenotypic expression that is prompted at the cellular level by local environmental conditions. C1 [Aslam, Rizwan; Schell, Stephen E.] Hamot Med Ctr, Div Otorhinolaryngol, Erie, PA 16550 USA. [McMahon, James T.] Cleveland Clin Fdn, Dept Anat Pathol, Cleveland, OH 44195 USA. RP Schell, SE (reprint author), Hamot Med Ctr, Div Otorhinolaryngol, 201 State St, Erie, PA 16550 USA. CR *9 11 RES, WORLD TRED CTR DUST Al-Rawi MM, 1998, LARYNGOSCOPE, V108, P1816, DOI 10.1097/00005537-199812000-00010 BACCETTI B, 1980, ANDROLOGIA, V12, P525 BALLENGER JJ, 1988, ANN OTO RHINOL LARYN, V97, P253 Banauch GI, 2003, AM J RESP CRIT CARE, V168, P54, DOI 10.1164/rccm.200211-1329OC Banauch Gisela I, 2005, Crit Care Med, V33, pS102, DOI 10.1097/01.CCM.0000151138.10586.3A BERTRAND B, 1984, Acta Oto-Rhino-Laryngologica Belgica, V38, P337 Brackbill RM, 2009, JAMA-J AM MED ASSOC, V302, P502, DOI 10.1001/jama.2009.1121 Burgess JL, 2004, J OCCUP ENVIRON MED, V46, P1013, DOI 10.1097/01.jom.0000141668.70006.52 Calderon-Garciduenas L, 2001, AM J RESP CELL MOL, V24, P132 CARSON JL, 1985, NEW ENGL J MED, V312, P463, DOI 10.1056/NEJM198502213120802 Christiani DC, 2008, OCCUP ENVIRON MED, V65, P430, DOI 10.1136/oem.2007.033977 Feldman DM, 2004, CHEST, V125, P1256, DOI 10.1378/chest.125.4.1256 FONZI L, 1982, EUR J RESPIR DIS, V63, P558 He JQ, 2008, EUR RESPIR J, V32, P25, DOI 10.1183/09031936.00040307 He JQ, 2009, THORAX, V64, P698, DOI 10.1136/thx.2008.111278 Herbert R, 2006, ENVIRON HEALTH PERSP, V114, P1853, DOI 10.1289/ehp.9592 Herbstman JB, 2005, ENVIRON RES, V99, P85, DOI 10.1016/j.envres.2004.08.010 Ho JC, 2001, AM J RESP CRIT CARE, V163, P983 Jorissen M, 2000, Acta Otorhinolaryngol Belg, V54, P333 Jorissen M, 2000, Acta Otorhinolaryngol Belg, V54, P343 Jorissen M, 1998, LARYNGOSCOPE, V108, P1042, DOI 10.1097/00005537-199807000-00017 Kleeberger SR, 2005, EXP TOXICOL PATHOL, V57, P147, DOI 10.1016/j.etp.2005.05.017 Levin S, 2002, AM J IND MED, V42, P545, DOI 10.1002/ajim.10154 Lioy PJ, 2002, ENVIRON HEALTH PERSP, V110, P703 McGee JK, 2003, ENVIRON HEALTH PERSP, V111, P972, DOI 10.1289/ehp.5930 Monini S, 2005, RHINOLOGY, V43, P251 Park KS, 2006, AM J RESP CELL MOL, V34, P151, DOI 10.1165/rcmb.2005-0332OC Pifferi M, 2009, THORAX, V64, P1077, DOI 10.1136/thx.2008.110940 Pleil JD, 2004, P NATL ACAD SCI USA, V101, P11685, DOI 10.1073/pnas.0404499101 Prezant DJ, 2002, NEW ENGL J MED, V347, P806, DOI 10.1056/NEJMoa021300 ROSSMAN CM, 1984, AM REV RESPIR DIS, V129, P161 Salzman SH, 2004, J OCCUP ENVIRON MED, V46, P113, DOI 10.1097/01.jom.0000111612.68916.d0 Samet JM, 2007, NEW ENGL J MED, V356, P2233, DOI 10.1056/NEJMp068287 Sandford AJ, 2001, AM J RESP CRIT CARE, V163, P469 Skloot G, 2004, CHEST, V125, P1248, DOI 10.1378/chest.125.4.1248 Skloot GS, 2009, CHEST, V135, P492, DOI 10.1378/chest.08-1391 VERRA F, 1995, AM J RESP CRIT CARE, V151, P630 Wong JYW, 2005, THORAX, V60, P582, DOI 10.1136/thx.2004.024638 Yang IA, 2008, THORAX, V63, P555, DOI 10.1136/thx.2007.079426 Yiin Lih-Ming, 2004, J Air Waste Manag Assoc, V54, P515 NR 41 TC 0 Z9 0 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD JAN PY 2011 VL 120 IS 1 BP 40 EP 48 PG 9 WC Otorhinolaryngology SC Otorhinolaryngology GA 712DS UT WOS:000286645500006 PM 21370679 ER PT J AU Kitani, Y Kanemaru, S Umeda, H Suehiro, A Kishimoto, Y Hirano, S Nakamura, T Ito, J AF Kitani, Yoshiharu Kanemaru, Shin-ichi Umeda, Hiroo Suehiro, Atsushi Kishimoto, Yo Hirano, Shigeru Nakamura, Tatsuo Ito, Juichi TI Laryngeal Regeneration Using Tissue Engineering Techniques in a Canine Model SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article; Proceedings Paper CT 89th Annual Meeting of the American-Broncho-Esophagological-Association CY MAY 28-29, 2009 CL Phoenix, AZ SP Amer Broncho Esophagol Assoc DE fascia; laryngeal regeneration; polypropylene; scaffold; tissue engineering ID GLOTTIC RECONSTRUCTION; STEM-CELLS; TRACHEA; FLAP; HEMILARYNGECTOMY; SCAFFOLD; ISLAND; MESH AB Objectives: We previously reported that polypropylene mesh covered with collagen sponge is a useful material for the regeneration of the trachea and the cricoid cartilage. The aim of this study was to regenerate larynges after partial hemilaryngectomy with this new biomaterial. Methods: A left partial hemilaryngectomy was performed on 12 adult beagles. The defect size was about 1.8 x 1.0 cm. Both sides of polypropylene mesh were coated with either 1% or 3% collagen sponge. This scaffold was wrapped in fascia lata harvested from the left thigh and then fixed in place over the defect. Endoscopic examinations were performed periodically. Six months after treatment, 3-dimensional computed tomographic scanning was performed. Vibratory examinations were also performed with excised larynges. Results: In the 1% collagen group, exposure or dislocation of the mesh was found in 3 of 6 cases, but in the 3% group, no exposure of the mesh was seen. The morphological findings in the vocal fold were better in the 3% group than in the 1% group, but a difference in the vertical levels of the vocal folds was found in both groups. Conclusions: This study suggests that 3% collagen coated polypropylene mesh wrapped with autologous fascia is a useful material for laryngeal regeneration. C1 [Kitani, Yoshiharu] Kyoto Univ, Grad Sch Med, Dept Otolaryngol Head & Neck Surg, Sakyo Ku, Kyoto 6068507, Japan. [Nakamura, Tatsuo] Kyoto Univ, Inst Frontier Med Sci, Dept Bioartificial Organs, Kyoto 6068507, Japan. [Kanemaru, Shin-ichi] Kitano Hosp, Tazuke Kofukai Med Res Inst, Dept Otolaryngol Head & Neck Surg, Osaka, Japan. RP Kitani, Y (reprint author), Kyoto Univ, Grad Sch Med, Dept Otolaryngol Head & Neck Surg, Sakyo Ku, 54 Kawahara Cho, Kyoto 6068507, Japan. CR Andrews RJ, 2001, ANN OTO RHINOL LARYN, V110, P543 AUBRY M, 1951, Ann Otolaryngol, V68, P129 BAILEY BJ, 1975, LARYNGOSCOPE, V85, P960, DOI 10.1288/00005537-197506000-00005 Bianco P, 2001, NATURE, V414, P118, DOI 10.1038/35102181 BLAUGRUND SM, 1975, LARYNGOSCOPE, V85, P935, DOI 10.1288/00005537-197506000-00002 Delaere P, 2007, LARYNGOSCOPE, V117, P1764, DOI 10.1097/MLG.0b013e3181238397 Hori Y, 2001, ASAIO J, V47, P206, DOI 10.1097/00002480-200105000-00008 Hori Y, 2003, INT J ARTIF ORGANS, V26, P241 Huber JE, 2003, ANN OTO RHINOL LARYN, V112, P428 Kanemaru SI, 2003, ANN OTO RHINOL LARYN, V112, P915 KOJIMA H, 1990, AM J OTOLARYNG, V11, P328, DOI 10.1016/0196-0709(90)90063-2 LANGER R, 1993, SCIENCE, V260, P920, DOI 10.1126/science.8493529 Lee BJ, 2006, CELLS TISSUES ORGANS, V184, P198, DOI 10.1159/000099627 Nakamura T, 2000, INT J ARTIF ORGANS, V23, P718 OKUMURA N, 1994, J THORAC CARDIOV SUR, V108, P337 Omori K, 2008, ANN OTO RHINOL LARYN, V117, P673 Omori K, 2008, ANN OTO RHINOL LARYN, V117, P609 Papakosta V, 2007, ORAL SURG ORAL MED O, V103, pE13, DOI 10.1016/j.tripleo.2006.11.040 WINEK TG, 1988, AM J SURG, V156, P235, DOI 10.1016/S0002-9610(88)80281-2 YAMASHITA M, 2007, ACTA OTO-LARYNGOL, V557, P66 NR 20 TC 2 Z9 2 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD JAN PY 2011 VL 120 IS 1 BP 49 EP 56 PG 8 WC Otorhinolaryngology SC Otorhinolaryngology GA 712DS UT WOS:000286645500007 PM 21370680 ER PT J AU Morrison, AR Smith, MA Bennett, EC AF Morrison, Aaron R. Smith, Matthew A. Bennett, Erica C. TI Pediatric Head and Neck Extramedullary Hematopoietic Disease: Case Series and Review of the Literature SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE acute lymphoblastic leukemia; acute myeloid leukemia; ethmoid sinus; extramedullary hematopoietic disease; orbit; parotid gland ID GRANULOCYTIC SARCOMA; LYMPHOBLASTIC LYMPHOMA; LEUKEMIA; CHILDREN; TUMORS AB We review 3 pediatric cases of extramedullary hematopoietic disease occurring in the orbit, ethmoid sinuses, and parotid gland, and present a review of the literature. Each of the 3 patients was taken to the operating room, and the biopsy specimens obtained were successful in establishing the diagnosis in every case. Head and neck manifestations of extramedullary hematopoietic disease are rare, indeed. However, these cases demonstrate that it is important for otolaryngologists, pediatricians, primary-care physicians, radiologists, and pathologists to maintain a high index of suspicion for extramedullary presentations of hematopoietic disease in the head and neck. A coordinated multidisciplinary approach, including the appropriate surgical approach for biopsy, will facilitate determination of the diagnosis and treatment plan. C1 [Morrison, Aaron R.; Bennett, Erica C.] Univ New Mexico Hosp, Dept Surg, Div Otolaryngol, Albuquerque, NM USA. [Bennett, Erica C.] Univ New Mexico Hosp, Dept Pediat, Albuquerque, NM USA. [Smith, Matthew A.] Univ Pittsburgh, Med Ctr, Dept Pathol, Pittsburgh, PA USA. RP Bennett, EC (reprint author), 1 Univ New Mexico, Div Otolaryngol, Dept Surg, MSC 10-5610, Albuquerque, NM 87131 USA. CR ALFORD M, 2006, HEAD NECK SURG OTOLA, P1504 Audouin J, 2003, INT J SURG PATHOL, V11, P271, DOI 10.1177/106689690301100404 BARTLETT N, 2010, CUMMINGS OTOLARYNGOL, P1674 Bidar M, 2007, OPHTHAL PLAST RECONS, V23, P87, DOI 10.1097/IOP.0b013e3180333a85 BYRD JC, 1995, J CLIN ONCOL, V13, P1800 CAVDAR AO, 1989, ACTA HAEMATOL-BASEL, V81, P80 Henderson JW, 1994, ORBITAL TUMORS Hijiya N, 2007, JAMA-J AM MED ASSOC, V297, P1207, DOI 10.1001/jama.297.11.1207 HOFFMAN R, 1995, HEMATOLOGY BASIC PRI Maitra A, 2001, AM J CLIN PATHOL, V115, P868 NEIMAN RS, 1981, CANCER, V48, P1426, DOI 10.1002/1097-0142(19810915)48:6<1426::AID-CNCR2820480626>3.0.CO;2-G PUI CH, 1988, J CLIN ONCOL, V6, P1008 Reinhardt D, 2002, LEUKEMIA LYMPHOMA, V43, P565, DOI 10.1080/10428190290012056 Rhee D, 2002, LARYNGOSCOPE, V112, P235, DOI 10.1097/00005537-200202000-00007 Shields JA, 1989, DIAGNOSIS MANAGEMENT Smock KJ, 2008, PEDIATR BLOOD CANCER, V51, P489, DOI [10.1002/pbc.21666, 10.1002/PBC.21666] Swerdlow SH, 2008, WHO CLASSIFICATION T, P168 Tanigawa M, 1998, OPHTHALMOLOGICA, V212, P202, DOI 10.1159/000027279 WILSON M, 1996, OPHTHALMOL CLIN N AM, V4, P539 Worch J, 2008, PEDIATR BLOOD CANCER, V50, P657, DOI 10.1002/pbc.21190 NR 20 TC 0 Z9 0 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD JAN PY 2011 VL 120 IS 1 BP 57 EP 62 PG 6 WC Otorhinolaryngology SC Otorhinolaryngology GA 712DS UT WOS:000286645500008 PM 21370681 ER PT J AU Phelan, E Griffin, J Timon, C AF Phelan, Eimear Griffin, John Timon, Conn TI Temporomandibular Joint Osteochondromatosis: An Unusual Cause of Preauricular Swelling SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE osteochondromatosis; temporomandibular joint ID SYNOVIAL OSTEOCHONDROMATOSIS AB We report an unusual and rare cause of preauricular swelling and review the most recent literature concerning synovial osteochondromatosis of the temporomandibular joint. We report the clinical and radiologic findings of a case of synovial osteochondromatosis of the temporomandibular joint that presented as preauricular swelling in a female patient. This disease typically affects large joints; fewer than 100 cases reported in the literature affect the temporomandibular joint. This case illustrates that disorders of the temporomandibular joint should also be included in the differential diagnosis of patients who present with a preauricular mass. C1 [Phelan, Eimear; Timon, Conn] Royal Victoria Eye & Ear Hosp, Dept Otolaryngol, Dublin, Ireland. [Griffin, John] Royal Victoria Eye & Ear Hosp, Dept Radiol, Dublin, Ireland. RP Phelan, E (reprint author), Apt 4 Cedarhurst Rd,Phoenix Pk Race Course, Dublin, Ireland. CR Crotty JM, 1996, RADIOL CLIN N AM, V34, P327 Hamilton Jason S, 2005, Ear Nose Throat J, V84, P342 Kamineni S, 2002, J BONE JOINT SURG BR, V84B, P961, DOI 10.1302/0301-620X.84B7.12766 Langguth DM, 2002, INTERN MED J, V32, P419, DOI 10.1046/j.1445-5994.2002.00260.x NORMAN JED, 1988, J CRANIO MAXILL SURG, V16, P212 Shibuya T, 2003, J ORAL PATHOL MED, V32, P441, DOI 10.1034/j.1600-0714.2003.00160.x VONHALLER A, 1764, ELEMENTA PHYSL NR 7 TC 0 Z9 0 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD JAN PY 2011 VL 120 IS 1 BP 63 EP 65 PG 3 WC Otorhinolaryngology SC Otorhinolaryngology GA 712DS UT WOS:000286645500009 PM 21370682 ER PT J AU Perez, R Adelman, C Sohmer, H AF Perez, Ronen Adelman, Cahtia Sohmer, Haim TI Several Mechanical Manipulations of the Wall of the Inner Ear Do Not Affect Air and Bone Conduction Auditory Thresholds SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE basilar membrane; bone conduction; mechanics; round window; threshold; traveling wave ID ROUND WINDOW ATRESIA; OTOSCLEROSIS; COCHLEA; SOUND; NOISE; OVAL AB Objectives: According to classic theories, auditory stimulation, whether air- or bone-conducted, has been thought to begin with sound-induced relative motion between the cochlear shell and the stapes footplate, producing a passive mechanical traveling wave along the basilar membrane. This study was designed to assess the effect of experimental mechanical manipulations of the cochlea on the auditory thresholds to air-conducted and bone-conducted stimulation. Methods: The left ear of Psammomys obesus (highest auditory sensitivity between 0.5 and 5.0 kHz) was initially ablated in all animals studied. After baseline recording of auditory nerve brain stem evoked response (ABR) thresholds to air-and bone-conducted broadband click stimulation from the right ear, a hole was drilled in the vestibule of that ear in 3 animals. In 2 other animals, the round window of the animals was immobilized. In 3 additional animals, the round window was widely perforated. Repeat ABR thresholds were then determined. Results: There was no change in ABR thresholds to both air- and bone-conducted stimulation following these manipulations. The ABR wave latency also did not change. Conclusions: It is likely that an alternative mode of cochlear excitation is possible. C1 [Sohmer, Haim] Hebrew Univ Jerusalem, Hadassah Med Sch, Inst Med Res Israel Canada, Dept Physiol, IL-91120 Jerusalem, Israel. [Perez, Ronen] Shaare Zedek Med Ctr, Dept Otolaryngol Head & Neck Surg, Jerusalem, Israel. [Adelman, Cahtia] Hadassah Univ Hosp, Speech & Hearing Ctr, IL-91120 Jerusalem, Israel. RP Sohmer, H (reprint author), Hebrew Univ Jerusalem, Hadassah Med Sch, Inst Med Res Israel Canada, Dept Physiol, POB 12272, IL-91120 Jerusalem, Israel. EM haims@ekmd.huji.ac.il CR Bekesy G., 1960, EXPT HEARING BOHMER A, 1990, LARYNGOSCOPE, V100, P389 Borrmann A, 2007, EUR ARCH OTO-RHINO-L, V264, P1103, DOI 10.1007/s00405-007-0305-1 Dean M S, 2000, Am J Audiol, V9, P131, DOI 10.1044/1059-0889(2000/011) Huber AM, 2008, OTOL NEUROTOL, V29, P1187, DOI 10.1097/MAO.0b013e31817ef49b KRINGLEBOTN M, 1995, J ACOUST SOC AM, V98, P192, DOI 10.1121/1.413746 Linder TE, 2003, OTOL NEUROTOL, V24, P259, DOI 10.1097/00129492-200303000-00021 MELZER P, 1984, HEARING RES, V15, P187, DOI 10.1016/0378-5955(84)90050-9 MUCHNIK C, 1990, AUDIOLOGY, V29, P55 Perez R, 2010, ACTA OTO-LARYNGOL, V130, P659, DOI 10.3109/00016480903373740 Perez Ronen, 2009, Journal of Basic and Clinical Physiology and Pharmacology, V20, P197 Preis M, 2009, OTOL NEUROTOL, V30, P657, DOI 10.1097/MAO.0b013e3181a66d0f Sichel JY, 2009, J INT ADV OTOL, V5, P246 Sichel JY, 1999, J OTOLARYNGOL, V28, P217 Sohmer Haim, 2004, Journal of Basic and Clinical Physiology and Pharmacology, V15, P1 Sohmer H, 2004, HEARING RES, V187, P105, DOI 10.1016/S0378-5955(03)00335-6 Stenfelt S, 2005, OTOL NEUROTOL, V26, P1245, DOI 10.1097/01.mao.0000187236.10842.d5 Stenfelt S, 2004, J ACOUST SOC AM, V115, P797, DOI 10.1121/1.1639903 TONNDORF J, 1962, J ACOUST SOC AM, V34, P1127, DOI 10.1121/1.1918259 Vincent R, 2006, OTOL NEUROTOL, V27, pS25, DOI 10.1097/01.mao.0000235311.80066.df Voss SE, 1996, J ACOUST SOC AM, V100, P1602, DOI 10.1121/1.416062 Wever EG, 1954, PHYSL ACOUSTICS ZWISLOCKI J, 1953, J ACOUST SOC AM, V25, P986, DOI 10.1121/1.1907231 NR 23 TC 3 Z9 4 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD JAN PY 2011 VL 120 IS 1 BP 66 EP 70 PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA 712DS UT WOS:000286645500010 PM 21370683 ER PT J AU Wycherly, BJ Berkowitz, F Noone, AM Kim, HJ AF Wycherly, Benjamin J. Berkowitz, Frank Noone, Anne-Michelle Kim, H. Jeffrey TI Computed Tomography and Otosclerosis: A Practical Method to Correlate the Sites Affected to Hearing Loss SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article; Proceedings Paper CT 113th Annual Meeting of the American-Academy-of-Otolaryngology-Head-and-Neck-Surgery-Foundation-and- OTO-EXPO CY OCT 04-07, 2009 CL San Diego, CA SP Amer Acad Otolaryngol Head & Neck Surg Fdn DE computed tomography; hearing loss; otosclerosis ID BONE-DENSITY MEASUREMENTS; COCHLEAR OTOSCLEROSIS; CT ANALYSIS; DENSITOMETRY; CAPSULE AB Objectives: We present a practical method for correlating computed tomography (CT) scans with hearing loss in otosclerosis Methods: We reviewed the CT scans of 18 patients (34 ears) with clinical otosclerosis who were seen between 2007 and 2008. The scans were reviewed by an otologist in a clinical office setting, followed by a blinded radiologist working at an imaging workstation. The 5 most commonly affected sites in otosclerosis were evaluated for evidence of otospongiosis and then correlated with the degree of air-bone gap and sensorineural hearing loss. Results: Positive CT findings were noted in 70.5% of ears, with a 94% concordance between readings. The sites affected included the ante fenestram (21 ears), round window niche (12), cochlear promontory (4), cochlear apex (3), and posterior fenestram (2). The average air-bone gap increased with each additional site of involvement within an otic capsule (p = 0.004). The bone conduction threshold also increased, on average, with each additional affected site (p = 0.047). Conclusions: Most patients with clinical evidence of otosclerosis have evidence of otosclerosis on CT that is readily detected in the office setting. Ears with more affected sites have a significantly greater degree of air-bone gap and sensorineural hearing loss. C1 [Wycherly, Benjamin J.; Kim, H. Jeffrey] Georgetown Univ, Dept Otolaryngol Head & Neck Surg, Washington, DC 20007 USA. [Berkowitz, Frank] Georgetown Univ, Dept Radiol, Washington, DC 20007 USA. [Noone, Anne-Michelle] Georgetown Univ, Dept Biostat, Washington, DC 20007 USA. [Noone, Anne-Michelle] Georgetown Univ, Dept Bioinformat, Washington, DC 20007 USA. [Noone, Anne-Michelle] Georgetown Univ, Dept Biomath, Washington, DC 20007 USA. RP Kim, HJ (reprint author), Georgetown Univ, Dept Otolaryngol Head & Neck Surg, Gorman 1,3800 S Reservoir Rd NW, Washington, DC 20007 USA. CR Grayeli AB, 2004, ACTA OTO-LARYNGOL, V124, P1136, DOI 10.1080/00016480410018188 Guneri EA, 1996, ANN OTO RHINOL LARYN, V105, P659 HUEB MM, 1991, OTOLARYNG HEAD NECK, V105, P396 HUIZING EH, 1987, ACTA OTO-LARYNGOL, V103, P464 Kiyomizu K, 2004, AURIS NASUS LARYNX, V31, P125, DOI 10.1016/j.anl.2004.01.006 MAFEE MF, 1985, RADIOLOGY, V156, P709 Min JY, 2010, AURIS NASUS LARYNX, V37, P23, DOI 10.1016/j.anl.2009.04.010 Naumann IC, 2005, ANN OTO RHINOL LARYN, V114, P709 SCHUKNECHT HF, 1985, LARYNGOSCOPE, V95, P1307 SHAMBAUGH GE, 1979, OTOLARYNGOLOGY, V1, P1 SWARTZ JD, 1985, RADIOLOGY, V155, P147 SWARTZ JD, 1985, AM J OTOL, V6, P476 SWARTZ JD, 1984, RADIOLOGY, V151, P703 Tringali S, 2007, ANN OTO RHINOL LARYN, V116, P195 VALVASSORI GE, 1985, AM J NEURORADIOL, V6, P661 VALVASSORI GE, 1993, OTOLARYNG CLIN N AM, V26, P359 VALVASSO.GE, 1969, ARCH OTOLARYNGOL, V89, P377 Vicente AD, 2006, OTOLARYNG HEAD NECK, V134, P685, DOI 10.1016/j.otohns.2005.11.030 1967, Laryngol, V76, P377 NR 19 TC 7 Z9 9 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD DEC PY 2010 VL 119 IS 12 BP 789 EP 794 PG 6 WC Otorhinolaryngology SC Otorhinolaryngology GA 697CY UT WOS:000285491400001 PM 21250549 ER PT J AU Leder, SB Burrell, MI Van Daele, DJ AF Leder, Steven B. Burrell, Morton I. Van Daele, Douglas J. TI Epiglottis Is Not Essential for Successful Swallowing in Humans SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE aspiration; deglutition; deglutition disorder; epiglottis ID ASPIRATION; MECHANISM; MOVEMENT; LARYNX AB Controversy has continued for well over 100 years regarding the role of the epiglottis in deglutition. We describe the effect of isolated epialottectomy on swallowing success in a case series of 3 adult human subjects with isolated epiglottectomy due to trauma, surgery, or cancerous erosion. The patients were 42,51 and 70 years of age, and swallowing was analyzed objectively with videofluoroscopy. All subjects exhibited successful swallowing with all food types: thin liquid, puree, and solid food. Specifically, the patient with traumatic epialottectomy exhibited rapid swallowing success, the patient with surgical epiglottectomy exhibited a short period of dysphagia due to postoperative edema, followed by swallowing success, and the patient with epiglottectomy due to cancerous erosion of the entire epiglottis exhibited long-term adaptation, with successful swallowing maintained. We conclude that the epiglottis is not essential for successful swallowing in humans, because individuals can readily adapt to isolated epiglottectomy and avoid tracheal aspiration. C1 [Leder, Steven B.] Yale Univ, Sch Med, Otolaryngol Sect, Dept Surg, New Haven, CT 06520 USA. [Burrell, Morton I.] Yale Univ, Sch Med, Dept Diagnost Radiol, New Haven, CT 06520 USA. [Van Daele, Douglas J.] Univ Iowa, Dept Otolaryngol Head & Neck Surg, Roy J & Lucille A Carver Coll Med, Iowa City, IA 52242 USA. RP Leder, SB (reprint author), Yale Univ, Sch Med, Otolaryngol Sect, Dept Surg, POB 208041, New Haven, CT 06520 USA. EM steven.leder@yale.edu CR ARDRAN GM, 1967, BRIT J RADIOL, V40, P372 EKBERG O, 1982, GASTROINTEST RADIOL, V7, P101, DOI 10.1007/BF01887619 Garon BR, 2002, DYSPHAGIA, V17, P57, DOI 10.1007/s00455-001-0102-8 Howes G B, 1889, J Anat Physiol, V23, P263 KIRCHNER JA, 1986, PHYSL LARYNX Logemann J, 1998, EVALUATION TREATMENT, V2nd Medda BK, 2003, AM J PHYSIOL-GASTR L, V284, pG933, DOI 10.1152/ajpgi.00395.2002 Mong A, 2003, AM J ROENTGENOL, V180, P207 Negus VE, 1949, COMP ANATOMY PHYSL L Perlman Adrienne L., 1994, Dysphagia, V9, P90, DOI 10.1007/BF00714593 PERLMAN AL, 1992, J SPEECH HEAR RES, V35, P734 PRESSMAN JJ, 1955, PHYSIOL REV, V35, P506 SASAKI CT, 1977, ARCH OTOLARYNGOL, V103, P169 VANDAELE DJ, 1995, J ANAT, V186, P1 Walton G L, 1878, J Physiol, V1, P303 ZEITELS SM, 1990, OTOLARYNG HEAD NECK, V103, P337 Zemlin W. R., 1988, SPEECH HEARING SCI NR 17 TC 1 Z9 1 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD DEC PY 2010 VL 119 IS 12 BP 795 EP 798 PG 4 WC Otorhinolaryngology SC Otorhinolaryngology GA 697CY UT WOS:000285491400002 PM 21250550 ER EF