FN Thomson Reuters Web of Science™
VR 1.0
PT J
AU Phillips, PH
Fray, KJ
Brodsky, MC
AF Phillips, PH
Fray, KJ
Brodsky, MC
TI Intermittent exotropia increasing with near fixation: a ''soft'' sign of
neurological disease
SO BRITISH JOURNAL OF OPHTHALMOLOGY
LA English
DT Reprint
ID CONVERGENCE INSUFFICIENCY; OCULAR MOTILITY
AB Aim: To examine the association of distance-near disparity with neurological disease in children with intermittent exotropia.
Methods: A retrospective analysis was performed of the medical records of all children with intermittent exotropia examined at the Arkansas Children's Hospital between 1989 and 2002. The study group consisted of children with intermittent exotropia who had a near deviation that exceeded the deviation at distance by at least 10 prism dioptres. The control group consisted of children with intermittent exotropia who had a distance deviation greater than or equal to the deviation at near. The main outcome measures were the prevalence of neurological abnormalities in the study and control groups.
Results: Among the 29 patients in the study group, 19 (66%) had a history of concurrent neurological abnormalities. Associated neurological conditions included developmental delay (10 patients), attention deficit disorder (four patients), cerebral palsy (four patients), history of intracranial haemorrhage (four patients), periventricular leucomalacia (three patients), seizures (two patients), cortical visual impairment (two patients), hydrocephalus (one patient), history of anoxic brain damage (one patient), history of encephalitis (one patient), and autism (one patient). Among the 37 patients in the control group, seven (19%) had a history of concurrent neurological abnormalities. The difference in the prevalence of neurological disease between the study group and the control group was significant (p = 0.0002).
Conclusion: Intermittent exotropia increasing with near fixation is associated with neurological disease in children.
C1 Univ Arkansas Med Sci, Dept Ophthalmol, Little Rock, AR 72205 USA.
Univ Arkansas Med Sci, Dept Pediat, Little Rock, AR 72205 USA.
RP Phillips, PH (reprint author), Arkansas Childrens Hosp, 800 Marshall St, Little Rock, AR 72202 USA.
EM phillipspaulh@uams.edu
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NR 14
TC 0
Z9 0
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 0007-1161
EI 1468-2079
J9 BRIT J OPHTHALMOL
JI Br. J. Ophthalmol.
PD DEC
PY 2005
VL 89
IS 12
BP 1669
EP 1671
PG 3
WC Ophthalmology
SC Ophthalmology
GA 985HR
UT WOS:000233368700038
ER
PT J
AU Mandell, DS
Walrath, CA
Manteuffel, B
Sgro, G
Pinto-Martin, JA
AF Mandell, DS
Walrath, CA
Manteuffel, B
Sgro, G
Pinto-Martin, JA
TI The prevalence and correlates of abuse among children with autism served
in comprehensive community-based mental health settings
SO CHILD ABUSE & NEGLECT
LA English
DT Article
DE autism; community-based mental health
ID PERVASIVE DEVELOPMENTAL DISORDERS; POSTTRAUMATIC-STRESS-DISORDER;
SEXUAL-ABUSE; PHYSICAL ABUSE; MULTIHANDICAPPED CHILDREN;
HANDICAPPED-CHILDREN; ADOLESCENTS; DISABILITIES; MALTREATMENT; ATTITUDES
AB Objective: To determine the demographic and psychosocial correlates of physical and sexual abuse among children with autism.
Methods: Data collected from 1997 to 2000 through the national evaluation of the Comprehensive Community Mental Health Services for Children and their Families Program on 156 children with autism were used. Data included a baseline assessment of child and family psychosocial experiences and presenting problems associated with referral into system-of-care service, demographic information, and a clinical record review to obtain psychiatric diagnosis. Binary and multinomial logistic regression was used to determine the association of different characteristics of children who were abused compared with those who were not abused.
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Conclusion: Based on the prevalence of abuse and its association with various behaviors, clinicians should be as attuned to the psychosocial histories of children with autism as they are for other children, and consider the potential of abuse when these behaviors are observed. (c) 2005 Elsevier Ltd. All rights reserved.
C1 Univ Penn, Ctr Mental Hlth Policy & Serv Res, Dept Psychiat, Sch Med, Philadelphia, PA 19104 USA.
Univ Penn, Leonard Davis Inst Hlth Econ, Philadelphia, PA 19104 USA.
ORC Macro, New York, NY USA.
ORC Macro, Atlanta, GA USA.
Univ Penn, Sch Nursing, Philadelphia, PA 19104 USA.
RP Mandell, DS (reprint author), Univ Penn, Ctr Mental Hlth Policy & Serv Res, Dept Psychiat, Sch Med, 3535 Market St,3rd Floor, Philadelphia, PA 19104 USA.
RI Mandelld, David/A-1044-2007; Mandell, David/H-2730-2012
OI Mandell, David/0000-0001-8240-820X
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NR 60
TC 32
Z9 32
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0145-2134
J9 CHILD ABUSE NEGLECT
JI Child Abuse Negl.
PD DEC
PY 2005
VL 29
IS 12
BP 1359
EP 1372
DI 10.1016/j.chiabu.2005.06.006
PG 14
WC Family Studies; Psychology, Social; Social Work
SC Family Studies; Psychology; Social Work
GA 989XG
UT WOS:000233706800004
PM 16293306
ER
PT J
AU Abramson, RK
Ravan, SA
Wright, HH
Wieduwilt, K
Wolpert, CM
Donnelly, SA
Pericak-Vance, MA
Cuccaro, ML
AF Abramson, R. K.
Ravan, S. A.
Wright, H. H.
Wieduwilt, K.
Wolpert, C. M.
Donnelly, S. A.
Pericak-Vance, M. A.
Cuccaro, M. L.
TI The relationship between restrictive and repetitive behaviors in
individuals with autism and obsessive compulsive symptoms in parents
SO CHILD PSYCHIATRY & HUMAN DEVELOPMENT
LA English
DT Article
DE autism; repetitive behaviors; insistence on sameness;
obsessive-compulsive features; phenotype
ID DIAGNOSTIC INTERVIEW; DISORDER; FAMILIES; COMPLEX; TRAITS; SCALE
AB This study investigated the relationship between repetitive behaviors in individuals with autism and obsessive-compulsive behaviors in parents. We hypothesized that repetitive behaviors in probands with autism would be associated with increased obsessive-compulsive behaviors in parents in sporadic families (1 known case of autism per family and no known history of autism). Parents with clinically significant Y-BOCS scores were more likely to have a family history of obsessive-compulsive disorder. The empirically derived Autism Diagnostic Interview-R (ADI-R) factor, Insistence on Sameness, was positively correlated with obsessive-compulsive behaviors in parents. Further, when probands were grouped on the basis of parental Y-BOCS scores (clinically significant versus non-clinically significant), probands whose parents had clinically significant Y-BOCS scores had higher ADI-R Insistence on Sameness factor scores. The findings of the current study of sporadic families extend previous work that has shown an association between restrictive/repetitive behaviors in probands with autism and obsessive-compulsive features in parents.
C1 Duke Univ, Med Ctr, Ctr Human Genet, Durham, NC 27710 USA.
Univ S Carolina, WS Hall Psychiat Inst, Columbia, SC 29208 USA.
RP Cuccaro, ML (reprint author), Duke Univ, Med Ctr, Ctr Human Genet, DUMC 3445, Durham, NC 27710 USA.
EM mike.euccaro@duke.edu
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NR 22
TC 22
Z9 22
PU SPRINGER
PI NEW YORK
PA 233 SPRING STREET, NEW YORK, NY 10013 USA
SN 0009-398X
J9 CHILD PSYCHIAT HUM D
JI Child Psychiat. Hum. Dev.
PD WIN
PY 2005
VL 36
IS 2
BP 155
EP 165
DI 10.1007/s10578-005-2973-7
PG 11
WC Psychology, Developmental; Pediatrics; Psychiatry
SC Psychology; Pediatrics; Psychiatry
GA 098XW
UT WOS:000241558100002
PM 16228144
ER
PT J
AU Cordes, SP
AF Cordes, SP
TI Molecular genetics of the early development of hindbrain serotonergic
neurons
SO CLINICAL GENETICS
LA English
DT Article
DE hindbrain patterning; neuronal differentiation; raphe nuclei;
serotonergic neuron; serotonin; transcriptional regulation
ID TRANSCRIPTION FACTOR; SONIC HEDGEHOG; FLOOR PLATE; PET-1; PROJECTIONS;
ORGANIZER; MIDBRAIN; POSITION; MICE; SPECIFICATION
AB The serotonergic (5HT) system plays a key role in modulating behaviors, such as appetite and anxiety and has been implicated in many human disorders of mood and mind. Recent studies have begun to identify the signaling molecules and transcriptional cascades governing 5HT neuron development in the hindbrain. Already at early stages, local differences in requirements of 5HT neuron development have become apparent. These studies point toward cryptic heterogeneity amongst 5HT neurons and suggest that 5HT neuron determination and differentiation may be more flexible and less absolute biologic processes than might have been expected. Ultimately, the intrinsic heterogeneity and environmental sensitivity of 5HT neruons may help explain the variability observed in some human behavioral disorders, such as autism spectrum disorder, and the less predictable behavioral consequences of fetal alcohol syndrome.
C1 Univ Toronto, Mt Sinai Hosp, Samuel Lunenfeld Res Inst, Dept Med & Mol Genet & Microbiol, Toronto, ON M5G 1X5, Canada.
RP Cordes, SP (reprint author), Univ Toronto, Mt Sinai Hosp, Samuel Lunenfeld Res Inst, Dept Med & Mol Genet & Microbiol, Room 865,600 Univ Ave, Toronto, ON M5G 1X5, Canada.
EM cordes@mshri.on.ca
RI Cordes, Sabine/A-5423-2012
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NR 36
TC 37
Z9 38
PU BLACKWELL PUBLISHING
PI OXFORD
PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND
SN 0009-9163
J9 CLIN GENET
JI Clin. Genet.
PD DEC
PY 2005
VL 68
IS 6
BP 487
EP 494
DI 10.1111/j.1399-0004.2005.00534.x
PG 8
WC Genetics & Heredity
SC Genetics & Heredity
GA 982NS
UT WOS:000233169500002
PM 16283875
ER
PT J
AU Blair, RJR
AF Blair, RJR
TI Responding to the emotions of others: Dissociating forms of empathy
through the study of typical and psychiatric populations
SO CONSCIOUSNESS AND COGNITION
LA English
DT Review
DE empathy; psychopath; autism
ID BILATERAL AMYGDALA DAMAGE; FUSIFORM FACE AREA; FRONTAL-LOBE DAMAGE;
FACIAL EXPRESSIONS; PSYCHOPATHIC TENDENCIES; IMPAIRED RECOGNITION;
PREFRONTAL CORTEX; ASPERGER-SYNDROME; PERSONALITY-DISORDER; CRIMINAL
PSYCHOPATHS
AB Empathy is a lay term that is becoming increasingly viewed as a unitary function within the field of cognitive neuroscience. In this paper, a selective review of the empathy literature is provided. It is argued from this literature that empathy is not a unitary system but rather a loose collection of partially dissociable neurocognitive systems. In particular, three main divisions can be made: cognitive empathy (or Theory of Mind), motor empathy, and emotional empathy. The two main psychiatric disorders associated with empathic dysfunction are considered autism and psychopathy. It is argued that individuals with autism show difficulties with cognitive and motor empathy but less clear difficulties with respect to emotional empathy. In contrast, individuals with psychopathy show clear difficulties with a specific form of emotional empathy but no indications of impairment with cognitive and motor empathy. Published by Elsevier Inc.
C1 NIMH, Mood & Anxiety Program, NIH, Dept Hlth & Human Serv, Bethesda, MD 20892 USA.
RP Blair, RJR (reprint author), NIMH, Mood & Anxiety Program, NIH, Dept Hlth & Human Serv, 15K N Dr,Room 206,MSC 2670, Bethesda, MD 20892 USA.
EM blairj@intra.nimh.nih.gov
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NR 179
TC 276
Z9 280
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 1053-8100
J9 CONSCIOUS COGN
JI Conscious. Cogn.
PD DEC
PY 2005
VL 14
IS 4
BP 698
EP 718
DI 10.1016/j.concog.2005.06.004
PG 21
WC Psychology, Experimental
SC Psychology
GA 995SL
UT WOS:000234124000004
PM 16157488
ER
PT J
AU Frith, U
de Vignemont, F
AF Frith, U
de Vignemont, F
TI Egocentrism, allocentrism, and Asperger syndrome
SO CONSCIOUSNESS AND COGNITION
LA English
DT Article
DE perspective-taking; theory of mind; self-awareness; mentalizing; social
cognition; autism; metarepresentation; executive functions; central
coherence
ID HIGH-FUNCTIONING ADULTS; PERSPECTIVE-TAKING; LANGUAGE IMPAIRMENT;
TEACHING THEORY; FALSE BELIEF; AUTISM; MIND; CHILDREN; SELF; CHILDHOOD
AB In this paper, we attempt to make a distinction between egocentrism and allocentrism in social cognition, based on the distinction that is made in visuo-spatial perception. We propose that it makes a difference to mentalizing whether the other person can be understood using an egocentric ("you") or an allocentric ("he/she/they") stance. Within an egocentric stance, the other person is represented in relation to the self. By contrast, within an allocentric stance, the existence or mental state of the other person needs to be represented as independent from the self. We suggest here that people with Asperger syndrome suffer from a disconnection between a strong naive egocentric stance and a highly abstract allocentric stance. We argue that the currently used distinction between first-person and third-person perspective-taking is orthogonal to the distinction between an egocentric and an allocentric stance and therefore cannot serve as a critical test of allocentrism. (c) 2005 Published by Elsevier Inc.
C1 UCL, Inst Cognit Neurosci, London WC1E 6BT, England.
RP Frith, U (reprint author), UCL, Inst Cognit Neurosci, London WC1E 6BT, England.
EM u.frith@ucl.ac.uk
RI Frith, Uta/C-1757-2008
OI Frith, Uta/0000-0002-9063-4466
CR ABELL F, 2000, J COGNITIVE DEV, V15, P1
[Anonymous], 1989, THEMES KAPLAN
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NR 68
TC 69
Z9 69
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 1053-8100
J9 CONSCIOUS COGN
JI Conscious. Cogn.
PD DEC
PY 2005
VL 14
IS 4
BP 719
EP 738
DI 10.1016/j.concog.2005.04.006
PG 20
WC Psychology, Experimental
SC Psychology
GA 995SL
UT WOS:000234124000005
PM 15996486
ER
PT J
AU Iacoboni, M
AF Iacoboni, M
TI Neural mechanisms of imitation
SO CURRENT OPINION IN NEUROBIOLOGY
LA English
DT Article
ID TRANSCRANIAL MAGNETIC STIMULATION; MIRROR NEURONS; COGNITIVE
NEUROSCIENCE; ACTION REPRESENTATION; SOCIAL-INTERACTION; PREMOTOR
CORTEX; MOTOR; AUTISM; FMRI; US
AB Recent advances in our knowledge of the neural mechanisms of imitation suggest that there is a core circuitry of imitation comprising the superior temporal sulcus and the 'mirror neuron system', which consists of the posterior inferior frontal gyrus and adjacent ventral premotor cortex, as well as the rostral inferior parietal lobule. This core circuitry communicates with other neural systems according to the type of imitation performed. Imitative learning is supported by interaction of the core circuitry of imitation with the dorsolateral prefrontal cortex and perhaps motor preparation areas namely, the mesial frontal, dorsal premotor and superior parietal areas. By contrast, imitation as a form of social mirroring is supported by interaction of the core circuitry of imitation with the limbic system.
C1 Ahmanson Lovelace Brain Mapping Ctr, Los Angeles, CA 90095 USA.
RP Iacoboni, M (reprint author), Ahmanson Lovelace Brain Mapping Ctr, 660 Charles E Young Dr S, Los Angeles, CA 90095 USA.
EM Iacoboni@loni.ucla.edu
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NR 50
TC 251
Z9 261
PU CURRENT BIOLOGY LTD
PI LONDON
PA 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND
SN 0959-4388
J9 CURR OPIN NEUROBIOL
JI Curr. Opin. Neurobiol.
PD DEC
PY 2005
VL 15
IS 6
BP 632
EP 637
DI 10.1016/j.conb.2005.10.010
PG 6
WC Neurosciences
SC Neurosciences & Neurology
GA 996IN
UT WOS:000234167700003
PM 16271461
ER
PT J
AU Spector, ND
Kelly, SF
AF Spector, ND
Kelly, SF
TI Sleep disorders, immunizations, sports injuries, autism
SO CURRENT OPINION IN PEDIATRICS
LA English
DT Review
DE autism; immunizations; sleep disorders; sports injuries
ID LOWER-EXTREMITY INJURY; SPECTRUM DISORDERS; RISK-FACTORS; CHILDREN;
ADOLESCENTS; EPIDEMIOLOGY; CONCUSSION; PREVENTION; PERTUSSIS; MELATONIN
AB Purpose of review The purpose of this article is to summarize and synthesize the recent literature in four very important areas for pediatric office practice: sleep disorders, new immunizations, sports injuries, and autism. Important articles in each area are highlighted.
Recent findings The management of pediatric and adolescent sleep disorders is in the forefront of the pediatric literature. The most recent literature cautions practitioners on prescribing pharmacologic treatment for sleep problems in children and adolescents. Several new immunizations targeted for adolescents are on the horizon. The newest recommendations for their delivery are outlined here. Recent sports injury literature emphasizes the need of the practitioner to address sports injury prevention and to provide anticipatory guidance at pediatric office visits. Finally, the past year's literature demonstrates that there is significant interest in autism spectrum disorders, but the clinicians' challenge for making the correct diagnosis of these disorders remains.
Summary The literature presented and summarized here will give the practicing pediatrician practical working knowledge of four important office-based pediatric topics: sleep disorders, new immunizations, sports injuries, and autism.
C1 St Christophers Hosp Children, Philadelphia, PA 19134 USA.
Drexel Univ, Coll Med, Philadelphia, PA 19104 USA.
RP Spector, ND (reprint author), St Christophers Hosp Children, Erie Ave & Front St, Philadelphia, PA 19134 USA.
EM Nancy.Spector@DrexelMed.edu
CR *ADV COMM IMM PRAC, CDC ACIP REC AD VACC
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NR 51
TC 0
Z9 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3261 USA
SN 1040-8703
J9 CURR OPIN PEDIATR
JI CURR. OPIN. PEDIATR.
PD DEC
PY 2005
VL 17
IS 6
BP 773
EP 786
DI 10.1097/01.mop.0000187194.20037.ee
PG 14
WC Pediatrics
SC Pediatrics
GA 989YC
UT WOS:000233709000017
PM 16282786
ER
PT J
AU Niklasson, L
Rasmussen, P
Oskarsdottir, S
Gillberg, C
AF Niklasson, L
Rasmussen, P
Oskarsdottir, S
Gillberg, C
TI Attention deficits in children with 22q.11 deletion syndrome
SO DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY
LA English
DT Article
ID CARDIO-FACIAL SYNDROME; 22Q11 DELETION; DEFICIT/HYPERACTIVITY DISORDER;
VELOCARDIOFACIAL-SYNDROME; ASPERGER-SYNDROME; PROFILE; ADOLESCENTS;
AUTISM
AB This study examined attention abilities of children with 22q.11 deletion syndrome. Thirty children (14 males, 16 females; age range 7 to 13y) were given comprehensive neuropsychological and neuropsychiatric assessments. Learning disability* was found in 13 children. Superiority in verbal over performance IQ was very common. Attention-deficit-hyperactivity disorder (mainly of inattentive subtype) was diagnosed in 13 children. There appeared to be a relation between low IQ and presence of autism spectrum problems. The presence of attention deficits was clearly supported by the scores on the Child Behavior Checklist and the Conners Questionnaire. On the Becker attention tests the reaction times were significantly longer in the two visual and auditory tests, indicating that the ability to sustain attention is critically impaired in this group. A tendency of inferiority on auditory compared with visual tests was noted but there were no specific problems with the focus-execute aspect of attention.
C1 Univ Gothenburg, Dept Child & Adolescent Psychol, S-41119 Gothenburg, Sweden.
Queen Silvia Childrens Hosp, Dept Pediat, Gothenburg, Sweden.
RP Niklasson, L (reprint author), Univ Gothenburg, Dept Child & Adolescent Psychol, Kungsgatan 12, S-41119 Gothenburg, Sweden.
EM lena.niklasson@vgregion.se
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NR 31
TC 28
Z9 28
PU CAMBRIDGE UNIV PRESS
PI NEW YORK
PA 40 WEST 20TH ST, NEW YORK, NY 10011-4211 USA
SN 0012-1622
J9 DEV MED CHILD NEUROL
JI Dev. Med. Child Neurol.
PD DEC
PY 2005
VL 47
IS 12
BP 803
EP 807
DI 10.1017/S0012162205001702
PG 5
WC Clinical Neurology; Pediatrics
SC Neurosciences & Neurology; Pediatrics
GA 989IT
UT WOS:000233666800004
PM 16288669
ER
PT J
AU Akmanoglu-Uludag, N
Batu, S
AF Akmanoglu-Uludag, N
Batu, S
TI Teaching naming relatives to individuals with autism using simultaneous
prompting
SO EDUCATION AND TRAINING IN DEVELOPMENTAL DISABILITIES
LA English
DT Article
ID DEVELOPMENTAL DELAYS; DISABILITIES; IDENTIFICATION; PRESCHOOLERS; ADULTS
AB This study examined the effectiveness of simultaneous prompting in teaching naming relatives to individuals with autism. Two 5.5 year old male participants who were diagnosed with autism were taught eight different relative names using simultaneous prompting. Maintenance and generalization data across materials, settings, and trainers were collected. Results revealed that simultaneous prompting was an effective way of teaching relative names to children with autism, and also that participants maintained and generalized the skills taught after training sessions were completed.
C1 Anadolu Univ, Engelliler Arastima Ensitusu, TR-26470 Eskisehir, Turkey.
RP Akmanoglu-Uludag, N (reprint author), Anadolu Univ, Engelliler Arastima Ensitusu, TR-26470 Eskisehir, Turkey.
EM nakmanoglu@anadolu.edu.tr
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NR 27
TC 18
Z9 18
PU COUNCIL EXCEPTIONAL CHILDREN
PI ARLINGTON
PA 1110 N GLEBE RD, ARLINGTON, VA 22201-5704 USA
SN 1547-0350
J9 EDUC TRAIN DEV DISAB
JI Educ. Train. Dev. Disabil.
PD DEC
PY 2005
VL 40
IS 4
BP 401
EP 410
PG 10
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA 992PK
UT WOS:000233896000008
ER
PT J
AU Clarke, DF
Roberts, W
Daraksan, M
Dupuis, A
McCabe, J
Wood, H
Snead, OC
Weiss, SK
AF Clarke, DF
Roberts, W
Daraksan, M
Dupuis, A
McCabe, J
Wood, H
Snead, OC
Weiss, SK
TI The prevalence of autistic spectrum disorder in children surveyed in a
tertiary care epilepsy clinic
SO EPILEPSIA
LA English
DT Article
DE autistic spectrum disorder; epilepsy; comorbidity; autism screening
questionnaire; pediatric sleep questionnaire
ID PERVASIVE DEVELOPMENTAL DISORDERS; SLEEP DISTURBANCE; DAYTIME BEHAVIOR;
ACTIVE EPILEPSY; CHILDHOOD; PATTERNS; PERFORMANCE; REGRESSION; SEIZURES
AB It is well documented that children with autistic spectrum disorder (ASD) have an increased prevalence of seizures; however, studies have not been done to evaluate the prevalence of ASD in children with epilepsy. This comorbidity is important to define as early diagnosis and intervention in some children with ASD has been shown to improve outcome.
Method: Children with epilepsy seen in a tertiary care epilepsy clinic were evaluated using validated autism screening questionnaires (ASQ). In addition, questions about sleep-related disorders, behavior, seizure characteristics, antiepileptic agents, and body mass index (BMI) were requested. An attempt was then made to determine if there was a correlation between the factors identified and ASD.
Results: Of the 107 questionnaires returned, 97 ASQ's were properly completed and used in this study. Approximately 32% of children fit the ASQ criteria for having ASD. Most children had not been previously diagnosed. Worst behavior and daytime sleepiness was seen in those at greater risk (p < 0.01). Seizures also occurred earlier (approximately 2 years) in children at risk of having ASD.
Conclusion: Though confirmatory diagnostic evaluations are needed, this questionnaire-based study suggests that children with epilepsy are at greater risk of having ASD, and illustrates the need for more clinical vigilance. Behavioral difficulties and daytime sleepiness identified in these children could potentially affect their ability to learn. It is of interest that the age of seizure onset identified in those at greater risk corresponds with the approximate age of regression identified in some children with ASD.
C1 Univ Tennessee, Ctr Hlth Sci, Comperhens Epilepsy Program, Dept Pediat,Div Neurol, Memphis, TN 38105 USA.
Univ Toronto, Hosp Sick Children, Dept Neurol, Toronto, ON M5G 1X8, Canada.
RP Clarke, DF (reprint author), Univ Tennessee, Ctr Hlth Sci, Comperhens Epilepsy Program, Dept Pediat,Div Neurol, 777 Washington Ave,Suite 250, Memphis, TN 38105 USA.
EM dclarke3@utmem.edu
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NR 48
TC 52
Z9 54
PU BLACKWELL PUBLISHING
PI OXFORD
PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND
SN 0013-9580
J9 EPILEPSIA
JI Epilepsia
PD DEC
PY 2005
VL 46
IS 12
BP 1970
EP 1977
DI 10.1111/j.1528-1167.2005.00343.x
PG 8
WC Clinical Neurology
SC Neurosciences & Neurology
GA 988CI
UT WOS:000233568600014
PM 16393164
ER
PT J
AU Gabis, L
Pomeroy, J
Andriola, MR
AF Gabis, L
Pomeroy, J
Andriola, MR
TI Autism and epilepsy: Cause, consequence, comorbidity, or coincidence?
SO EPILEPSY & BEHAVIOR
LA English
DT Article
DE autism; children; diagnosis; electroencephalography; epilepsy
ID SPECTRUM DISORDERS; EEG ABNORMALITIES; CHILDREN; ADOLESCENTS;
REGRESSION; CHILDHOOD; ADULTS
AB Autism is associated with epilepsy in early childhood, with evidence Suggesting that individuals with both autism and more severe cognitive impairment are at higher risk. However, the incidence of an abnormal electroencephalogram and/or epilepsy in the full range of pervasive developmental disorders (PDDs) is not well defined. This naturalistic Study addresses the incidence of epilepsy and electroencephalographic abnormalities in children with PDDs. The clinical history and electroencephalograms of 56 children diagnosed with PDD-not otherwise specified, autism, or Asperger syndrome were retrospectively reviewed. Forty percent of children with autism were diagnosed with epilepsy. Abnormal electroencephalograms and epilepsy occurred at significantly higher rates in children in the more impaired range of the autism spectrum (P < 0.05). These findings suggest that the use of neurological investigative techniques such as electroencephalography should be a consequence of careful clinical evaluation and Should be considered routinely during evaluation of more impaired individuals. (C) 2005 Elsevier Inc. All rights reserved.
C1 Safra Childrens Hosp, Child Dev Ctr, Tel Hashomer, Israel.
SUNY Stony Brook, Dept Pediat, Stony Brook, NY 11794 USA.
SUNY Stony Brook, Dept Neurol, Stony Brook, NY 11794 USA.
RP Gabis, L (reprint author), Safra Childrens Hosp, Child Dev Ctr, Tel Hashomer, Israel.
EM gabis@post.tau.ac.il
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
Filipek PA, 2000, NEUROLOGY, V55, P468
Rossi PG, 2000, BRAIN DEV-JPN, V22, P102
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NR 14
TC 52
Z9 53
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 1525-5050
J9 EPILEPSY BEHAV
JI Epilepsy Behav.
PD DEC
PY 2005
VL 7
IS 4
BP 652
EP 656
DI 10.1016/j.yebeh.2005.08.008
PG 5
WC Behavioral Sciences; Clinical Neurology; Psychiatry
SC Behavioral Sciences; Neurosciences & Neurology; Psychiatry
GA 994LP
UT WOS:000234033600007
PM 16246635
ER
PT J
AU Wentz, E
Lacey, JH
Waller, G
Rastam, M
Turk, J
Gillberg, C
AF Wentz, E
Lacey, JH
Waller, G
Rastam, M
Turk, J
Gillberg, C
TI Childhood onset neuropsychiatric disorders in adult eating disorder
patients - A pilot study
SO EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
LA English
DT Article
DE eating disorders; autism spectrum disorders; AD/HD; tic disorders
ID DEFICIT HYPERACTIVITY DISORDER; PRIMARY-SCHOOL CHILDREN; 10-YEAR
FOLLOW-UP; ANOREXIA-NERVOSA; PERSONALITY-DISORDER; DIAGNOSTIC INTERVIEW;
ASPERGER-SYNDROME; COMMUNICATION DISORDERS; 7-YEAR-OLD CHILDREN;
COMORBIDITY
AB Background: Autism spectrum disorders (ASD) have been suggested to be overrepresented in anorexia nervosa. This study aimed to explore the comorbidity of ASD and other childhood onset neuropsychiatric disorders (COND) [attention-deficit/hyperactivity disorder (AD/HD) and tic disorders] in a group of severe eating disorder (ED) patients.
Method: Thirty female ED patients from a specialist hospital clinic were examined on measures tapping into COND and personality disorders.
Results: In our group of longstanding ED, 53% had at least one COND diagnosis; 23% had ASD, 17% had AD/HD, and 27% had a tic disorder.
Conclusion: These preliminary data suggest that COND may be common in patients with severe ED and should be kept in mind when treating these patients.
C1 Univ Gothenburg, Dept Child & Adoleacent Psychiat, S-41119 Gothenburg, Sweden.
Univ London St Georges Hosp, Sch Med, Dept Mental Hlth, London SW17 0RE, England.
Univ London St Georges Hosp, Sch Med, St Georges Eating Disorder Serv, London SW17 0RE, England.
RP Wentz, E (reprint author), Univ Gothenburg, Dept Child & Adoleacent Psychiat, Kungsgatan 12, S-41119 Gothenburg, Sweden.
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NR 34
TC 41
Z9 41
PU DR DIETRICH STEINKOPFF VERLAG
PI DARMSTADT
PA PO BOX 10 04 62, D-64204 DARMSTADT, GERMANY
SN 1018-8827
J9 EUR CHILD ADOLES PSY
JI Eur. Child Adolesc. Psych.
PD DEC
PY 2005
VL 14
IS 8
BP 431
EP 437
DI 10.1007/s00787-005-0494-3
PG 7
WC Psychology, Developmental; Pediatrics; Psychiatry
SC Psychology; Pediatrics; Psychiatry
GA 992EQ
UT WOS:000233867600003
PM 16341499
ER
PT J
AU Ylisaukko-oja, T
Rehnstrom, K
Auranen, M
Vanhala, R
Alen, R
Kempas, E
Ellonen, P
Turunen, JA
Makkonen, I
Riikonen, R
von Wendt, TN
von Wendt, L
Peltonen, L
Jarvela, I
AF Ylisaukko-oja, T
Rehnstrom, K
Auranen, M
Vanhala, R
Alen, R
Kempas, E
Ellonen, P
Turunen, JA
Makkonen, I
Riikonen, R
von Wendt, TN
von Wendt, L
Peltonen, L
Jarvela, I
TI Analysis of four neuroligin genes as candidates for autism
SO EUROPEAN JOURNAL OF HUMAN GENETICS
LA English
DT Article
DE linkage disequilibrium; linkage; mutation screening; association
analysis; Asperger syndrome; synapse
ID LINKAGE ANALYSIS; DEVELOPMENTAL DISORDERS; SPECTRUM DISORDERS;
MUTATIONS; IDENTIFICATION; PSD-95; FAMILY; ASSOCIATION; PREVALENCE;
PHENOTYPE
AB Neuroligins are cell-adhesion molecules located at the postsynaptic side of the synapse. Neuroligins interact with beta-neurexins and this interaction is involved in the formation of functional synapses. Mutations in two X-linked neuroligin genes, NLGN3 and NLGN4, have recently been implicated in pathogenesis of autism. The neuroligin gene family consists of five members (NLGN1 at 3q26, NLGN2 at 17p13, NLGN3 at Xq13, NLGN4 at Xp22, and NLGN4Y at Yq11), of which NLGN1 and NLGN3 are located within the best loci observed in our previous genome-wide scan for autism in the Finnish sample. Here, we report a detailed molecular genetic analysis of NLGN1, NLGN3, NLGN4, and NLNG4Y in the Finnish autism sample. Mutation analysis of 30 probands selected from families producing linkage evidence for Xq13 and/or 3q26 loci revealed several polymorphisms, but none of these seemed to be functional. Family-based association analysis in 100 families with autism spectrum disorders yielded only modest associations at NLGN1 (rs1488545, P = 0.002), NLGN3 (DXS7132, P = 0.014), and NLGN4 (DXS996, P = 0.031). We conclude that neuroligin mutations most probably represent rare causes of autism and that it is unlikely that the allelic variants in these genes would be major risk factors for autism.
C1 Natl Publ Hlth Inst, Dept Mol Med, Biomedicum, Helsinki 00251, Finland.
Univ Helsinki, Dept Med Genet, Helsinki, Finland.
Hosp Children & Adolescent, Unit Child Neurol, Helsinki, Finland.
Cent Hosp Cent Finland, Dept Child Neurol, Jyvaskyla, Finland.
Univ Kuopio, Childrens Hosp, Dept Child Neurol, FIN-70211 Kuopio, Finland.
Univ Helsinki, Cent Hosp, Genet Mol Lab, Helsinki, Finland.
RP Ylisaukko-oja, T (reprint author), Natl Publ Hlth Inst, Dept Mol Med, Biomedicum, POB 104, Helsinki 00251, Finland.
EM tero.ylisaukko-oja@ktl.fi
RI Jarvela, Irma/L-5836-2013
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NR 42
TC 72
Z9 77
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1018-4813
J9 EUR J HUM GENET
JI Eur. J. Hum. Genet.
PD DEC
PY 2005
VL 13
IS 12
BP 1285
EP 1292
DI 10.1038/sj.ejhg.5201474
PG 8
WC Biochemistry & Molecular Biology; Genetics & Heredity
SC Biochemistry & Molecular Biology; Genetics & Heredity
GA 986QG
UT WOS:000233464200008
PM 16077734
ER
PT J
AU Stoodley, CJ
Fawcett, AJ
Nicolson, RI
Stein, JF
AF Stoodley, CJ
Fawcett, AJ
Nicolson, RI
Stein, JF
TI Impaired balancing ability in dyslexic children
SO EXPERIMENTAL BRAIN RESEARCH
LA English
DT Article
DE developmental dyslexia; balance; cerebellum; magnocellular
ID ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; DEFICIT HYPERACTIVITY
DISORDER; DEVELOPMENTAL DYSLEXIA; CEREBELLAR ABNORMALITIES; HYPOTHESIS;
ADULTS; PERFORMANCE; COMMENT/; AUTISM
AB Children with developmental dyslexia struggle to learn to read and spell despite adequate intelligence and educational opportunity. Several lines of research are attempting to establish the neurobiological basis of dyslexia, and low-level sensory and motor deficits have been found in dyslexic populations; furthermore, behavioural and imaging data point to cerebellar dysfunction in dyslexia. To investigate this, normal readers (n=19) and children with developmental dyslexia (n=16) were asked to perform various cognitive, literacy, and balancing tasks. Children balanced on the left or right foot, with eyes open or closed, for a period of 10 s during which their movements were recorded with a motion-tracking system. Dyslexic children were less stable than the control children in both eyes-open conditions (left foot P=0.02, right foot P=0.012). While there were no group differences during the eyes-closed conditions, the dyslexic children dropped a foot to correct balance significantly more often than control children (P < 0.05). Incidence analysis showed that 50% of the dyslexic group fell into the 'impaired' category on the eyes-open balancing tasks; when the mean balancing scores and the foot drops were considered, only three of our dyslexic children showed no evidence of balancing difficulties. There were strong correlations between reading and spelling scores and the mean eyes-open balancing score (r=0.52 and 0.44, respectively). Thus, while not all children with developmental dyslexia show impaired balancing skills, low-level motor dysfunction may be associated with impaired literacy development. This could be due to several factors, including the involvement of the cerebellum, the magnocellular system, or more general developmental immaturity.
C1 Univ Oxford, Physiol Lab, Oxford OX1 3PT, England.
Univ Sheffield, Dept Psychol, Sheffield S10 2TN, S Yorkshire, England.
RP Stoodley, CJ (reprint author), Univ Oxford, Physiol Lab, Parks Rd, Oxford OX1 3PT, England.
EM cjs@physiol.ox.ac.uk
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NR 54
TC 36
Z9 37
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0014-4819
EI 1432-1106
J9 EXP BRAIN RES
JI Exp. Brain Res.
PD DEC
PY 2005
VL 167
IS 3
BP 370
EP 380
DI 10.1007/s00221-005-0042-x
PG 11
WC Neurosciences
SC Neurosciences & Neurology
GA 992IE
UT WOS:000233876800007
PM 16044303
ER
PT J
AU Gellatly, J
McVittie, C
Tiliopoulos, N
AF Gellatly, J
McVittie, C
Tiliopoulos, N
TI Predicting parents' decisions on MMR immunisation: a mixed method
investigation
SO FAMILY PRACTICE
LA English
DT Article
DE attitudes; immunization; MMR vaccine; parents
ID CAUSAL ASSOCIATION; RUBELLA VACCINE; MEASLES; AUTISM; POPULATION;
CHILDREN; MUMPS; COMMUNICATION; RISK
AB Background. Increasing uptake rates for MMR vaccination requires an understanding of factors leading parents to decide for and against vaccination, particularly in the light of recent developments.
Objective. We investigated factors relevant to immunising and non-immunising parents and the extent to which these factors predicted their decisions.
Methods. The study was conducted in Edinburgh, UK. A two-stage mixed method design was used. Delphi technique elicited parents' views of factors relevant to MMR immunisation. Twenty-six factors identified as relevant were incorporated into a final questionnaire. Using cluster sampling, the final questionnaire was distributed to parents recruited through a group of local nurseries. 110 parents participated: eighty (72.7%) had had their child MMR vaccinated, thirty (27.3%) had refused the vaccine. The factors in the final questionnaire were analysed against vaccination status using a direct binary logistic regression model.
Results. Four factors significantly predicted vaccination status, (prediction toward 'yes vaccination'). These were the influence of current research (OR = 0.18, 95% CI = 0.07-0.51), the helpfulness of leaflets and information packs (OR = 3.27, 95% CI = 1.38-7.75), the importance of eradication of rubella (OR = 2.42, 95% CI = 1.01-5.78), and the importance attached to the risk of adverse reactions (OR = 0.65, 95% CI = 0.48-0.87).
Conclusions. Differences between immunising and non-immunising parents lie in the importance attached to four relevant factors. Excluding risk of adverse reactions, these factors have not been previously identified as salient and require to be explored further. Health advice to parents should highlight the identified importance attached to eradicating rubella and explicitly reflect research findings.
C1 Queen Margaret Univ Coll, Sch Sci Media & Commun, Edinburgh EH12 8TS, Midlothian, Scotland.
Univ Manchester, Sch Nursing, Manchester M13 9PL, Lancs, England.
Univ London Queen Mary Coll, Sch Social Sci Media & Commun, Edinburgh, Midlothian, Scotland.
RP Gellatly, J (reprint author), Queen Margaret Univ Coll, Sch Sci Media & Commun, Edinburgh EH12 8TS, Midlothian, Scotland.
EM cmcvittie@qmuc.ac.uk
RI McVittie, Chris/G-3702-2013; Gellatly, Judith/O-4287-2014
OI McVittie, Chris/0000-0003-0657-7524; Gellatly,
Judith/0000-0002-5134-5581
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NR 34
TC 8
Z9 8
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0263-2136
J9 FAM PRACT
JI Fam. Pr.
PD DEC
PY 2005
VL 22
IS 6
BP 658
EP 662
DI 10.1093/fampra/cmi066
PG 5
WC Medicine, General & Internal
SC General & Internal Medicine
GA 989JJ
UT WOS:000233668400015
PM 16024553
ER
PT J
AU Pioggia, G
Igliozzi, R
Ferro, M
Ahluwalia, A
Muratori, F
De Rossi, D
AF Pioggia, G
Igliozzi, R
Ferro, M
Ahluwalia, A
Muratori, F
De Rossi, D
TI An android for enhancing social skills and emotion recognition in people
with autism
SO IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING
LA English
DT Article
DE autism; biomimetics; recognition of emotional expressions; robot-based
treatment method; social attention
ID PERVASIVE DEVELOPMENTAL DISORDERS; ASPERGER-SYNDROME; REVISED VERSION;
CHILDREN; INDIVIDUALS; SPECTRUM; ILLUSION
AB It is well documented that the processing of social and emotional information is impaired in people with autism. Recent studies have shown that individuals, particularly those with high functioning autism, can learn to cope with common social situations if they are made to enact possible scenarios they may encounter in real life during therapy. The main aim of this work is to describe an interactive life-like facial display (FACE) and a supporting therapeutic protocol that will enable us to verify if the system can help children with autism to learn, identify, interpret, and use emotional information and extend these skills in a socially appropriate, flexible, and adaptive context. The therapeutic setup consists of a specially equipped room in which the subject, under the supervision of a therapist, can interact with FACE. The android display and associated control system has automatic facial tracking, expression recognition, and eye tracking. The treatment scheme is based on a series of therapist-guided sessions in which a patient communicates with FACE through an interactive console. Preliminary data regarding the exposure to FACE of two children are reported.
C1 Univ Pisa, Fac Engn, Interdept Res Ctr E Piaggio, I-56100 Pisa, Italy.
Univ Pisa, Sci Inst Stella Maris, Dept Dev Neurosci, I-56100 Pisa, Italy.
RP Pioggia, G (reprint author), Univ Pisa, Fac Engn, Interdept Res Ctr E Piaggio, I-56100 Pisa, Italy.
EM giovanni.pioggia@ing.unipi.it
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NR 39
TC 24
Z9 24
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 1534-4320
J9 IEEE T NEUR SYS REH
JI IEEE Trans. Neural Syst. Rehabil. Eng.
PD DEC
PY 2005
VL 13
IS 4
BP 507
EP 515
DI 10.1109/TNSRE.2005.856076
PG 9
WC Engineering, Biomedical; Rehabilitation
SC Engineering; Rehabilitation
GA 993GU
UT WOS:000233943400010
PM 16425833
ER
PT J
AU McConnell, BA
Bryson, SE
AF McConnell, BA
Bryson, SE
TI Visual attention and temperament: Developmental data from the first 6
months of life
SO INFANT BEHAVIOR & DEVELOPMENT
LA English
DT Article
DE visual attention; disengagement; temperament; infants
ID EARLY INFANCY; AUTISM; DISENGAGEMENT; COMPONENTS; DEFICITS; ABILITY;
AROUSAL
AB Infants were assessed longitudinally at 2, 4, and 6 months of age on a visual orienting task. Once engaged on a center stimulus, the latency to initiate a saccade to a peripheral stimulus was measured. The critical manipulation was whether, upon presentation of the peripheral stimulus, the center stimulus remained on (disengage trials) or was turned off (shift trials). Temperament was assessed using the Infant Behavior Questionnaire (IBQ). Latencies to shift attention decreased with age (i.e., 6 < 4 < 2 months.). A disengage-shift difference favoring shift trials was found at 2 months; this difference was only marginally significant at 4 and 6 months. At 6 months, ease of disengagement was associated with infants being more likely to smile and less likely to exhibit frustration. Our findings replicate and extend previous cross-sectional research by showing that the disengage operation undergoes a major developmental change within the first 4 months. Discussion focuses on the relationship between attentional. disengagement and the regulation of emotional states. (c) 2005 Elsevier Inc. All rights reserved.
C1 York Univ, N York, ON M3J 1P3, Canada.
Hosp Sick Children, Brain & Behav Div, Res Inst, Toronto, ON M5G 1X8, Canada.
RP McConnell, BA (reprint author), St Josephs Healthcare, Anxiety Treatment & Res Ctr, 6th Floor,Fontbonne Bldg,50 Charlon Ave E, Hamilton, ON L8N 4A6, Canada.
EM bam@bethmcconnell.ca
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NR 40
TC 14
Z9 14
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0163-6383
J9 INFANT BEHAV DEV
JI Infant Behav. Dev.
PD DEC
PY 2005
VL 28
IS 4
BP 537
EP 544
DI 10.1016/j.infbeh.2005.09.002
PG 8
WC Psychology, Developmental
SC Psychology
GA 986UW
UT WOS:000233476200012
ER
PT J
AU Narayan, J
Chakravarti, SN
David, J
Kanniappan, M
AF Narayan, J
Chakravarti, SN
David, J
Kanniappan, M
TI Analysis of educational support systems for children with mental
retardation and autism spectrum disorders
SO INTERNATIONAL JOURNAL OF REHABILITATION RESEARCH
LA English
DT Article
DE educational support; children; mental retardation; autism spectrum
disorders
AB Children with autism spectrum disorders (ASDs) have the right to education. In India, ASDs are covered by the National Trust Act, which focuses on guardianship. Education is predominantly provided by non-government organizations and varied models are used in educating the children. This study aimed to compile information on the current educational models and to find out the feasibility for replication. The major models found to be in use were: special schools, inclusive schools, home-based instruction and units established by parent groups. The choice of model depended on the child's level of functioning and parental aspirations. About 46.8% preferred home-based instruction, while 25.8% were enrolled in special schools and 19.4% were in inclusive schools. All children initially needed home-based training. Picture activity schedules, discrete trial training, sensory integration and structured environment were found to be effective in the education of children with ASDs. Although children improved with home-based instruction, parents expressed stress. About 73% of the parents were eager to send their children to a suitable school, but dissatisfied with the existing facilities. Recognizing ASDs as a disability in the Persons with Disabilities Act (1995) will strengthen and promote the education of children with these conditions.
C1 Natl Inst Mentally Handicapped, Secunderabad 500009, Andhra Pradesh, India.
RP Narayan, J (reprint author), Natl Inst Mentally Handicapped, Secunderabad 500009, Andhra Pradesh, India.
EM jnarayans@yahoo.com
RI Narayan, Jagdish/D-1874-2009
CR *GOV IND, 1999, NAT TRUST WELF PERS
*GOV IND, 1995, PERS DIS EQ OPP PROT
LOVAAS OI, 1987, J CONSULT CLIN PSYCH, V55, P3, DOI 10.1037/0022-006X.55.1.3
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NARAYAN J, 2000, NIMH FUNCTIONAL ASSE
PERRY A, 2003, EVIDENCE BASED PRACT, P16
REDDY SHK, 2000, DIRECTORY INSTITUTIO
Sattler J. M., 2002, ASSESSMENT CHILDREN
SMITH DD, 2004, INTRO SPECIAL ED, P431
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NR 10
TC 3
Z9 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3261 USA
SN 0342-5282
J9 INT J REHABIL RES
JI Int. J. Rehabil. Res.
PD DEC
PY 2005
VL 28
IS 4
BP 365
EP 368
DI 10.1097/00004356-200512000-00011
PG 4
WC Rehabilitation
SC Rehabilitation
GA 998HU
UT WOS:000234310100011
PM 16319564
ER
PT J
AU Okada, S
Goto, H
Ueno, K
AF Okada, S
Goto, H
Ueno, K
TI Effect of social skills training including rehearsal of game activities:
Comparison of children with LD, ADHD, and Asperger syndrome
SO JAPANESE JOURNAL OF EDUCATIONAL PSYCHOLOGY
LA Japanese
DT Article
DE social skills training; rehearsal of game activities; elementary school
boys with LD, ADHD; or Asperger syndrome
ID LEARNING-DISABILITIES; HYPERACTIVITY; INTERVENTIONS; STUDENTS; DEFICITS;
AUTISM
AB The present study. examined the effect of social skills training (SST). including rehearsal of game activities. Participants were 3 elementary school boys (1 fourth grader and 2 fifth graders) with learning disabilities, attention deficit/hyperactivity disorder or Asperger syndrome. The boys' behavior during free time was rated on 4 categories of interaction among children, and on a social skills scale. After training, 2 of the boys' cooperative behavior improved, and they had a reduced amount of aggressive and negative behavior, but the third boy did not improve. Because after the social skills training involving rehearsal of game activities, the behavior of some but not all the boys changed, this suggests that each disability requires its own method of social skills training. Remaining problems are assessment, and how to achieve generalization.
C1 Tokyo Ymca Toyota Ctr, Tokyo, Japan.
Tokyo Gakugei Univ, Dept Technol Educ, Tokyo, Japan.
RP Okada, S (reprint author), Tokyo Ymca Toyota Ctr, Tokyo, Japan.
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World Health Organization, 1993, ICD10 CLASS MENT BEH
NR 18
TC 0
Z9 0
PU JAPANESE ASSOC EDUCATIONAL PSYCHOLOGY
PI TOKYO
PA 5-24-6-7F HONGO, BUMKYO-KU, TOKYO, 113-0033, JAPAN
SN 0021-5015
J9 JPN J EDUC PSYCHOL
JI Jpn. J. Educ. Psychol.
PD DEC
PY 2005
VL 53
IS 4
BP 565
EP 578
PG 14
WC Psychology, Educational
SC Psychology
GA 005HK
UT WOS:000234813000011
ER
PT J
AU Murphy, C
Barnes-Holmes, D
Barnes-Holmes, Y
AF Murphy, C
Barnes-Holmes, D
Barnes-Holmes, Y
TI Derived manding in children with autism: Synthesizing Skinner's verbal
behavior with relational frame theory
SO JOURNAL OF APPLIED BEHAVIOR ANALYSIS
LA English
DT Article
DE derived transfer; mands; language; autism spectrum disorder; children
ID EQUIVALENCE-RELATIONS; ARBITRARY
AB Mand functions for two stimuli (A1 and A2) were trained for 3 children with autism and were then incorporated into two related conditional discriminations (A1-B1/A2-B2 and B1-C1/B2-C2). Tests were conducted to probe for a derived transfer of mand response functions from A1 and A2 to C1 and C2, respectively. When I participant failed to demonstrate derived transfer of mand response functions, transfer training using exemplars was conducted. When participants had demonstrated derived transfer of mand functions, the XI and X2 tokens that were employed as reinforcers for mand responses were incorporated into two conditional discriminations (X1-Y1/X2-Y2 and Y1-Z1/Y2-Z2). Tests were conducted for derived transfer of reinforcing functions. Finally, tests were conducted to determine if the participants would demonstrate derived manding for the derived reinforcers (present C1 and C2 to mand for Z1 and Z2, respectively). Derived transfer of functions was observed when the sequence of training and testing was reversed (i.e., training and testing reinforcing functions before mand response functions) and when only minimal instructions were provided.
C1 Natl Univ Ireland, Dept Psychol, Maynooth, Kildare, Ireland.
RP Murphy, C (reprint author), Natl Univ Ireland, Dept Psychol, Maynooth, Kildare, Ireland.
EM murphycarol1@netscape.net
CR BARNES D, 1995, PSYCHOL REC, V45, P405
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NR 23
TC 22
Z9 22
PU JOURNAL APPL BEHAV ANAL
PI LAWRENCE
PA DEPT HUMAN DEVELOPMENT, UNIV KANSAS, LAWRENCE, KS 66045 USA
SN 0021-8855
J9 J APPL BEHAV ANAL
JI J. Appl. Behav. Anal.
PD WIN
PY 2005
VL 38
IS 4
BP 445
EP 462
DI 10.1901/jaba.2005.97-04
PG 18
WC Psychology, Clinical
SC Psychology
GA 991KI
UT WOS:000233812500002
PM 16463526
ER
PT J
AU Williams, G
Perez-Gonzalez, LA
Queiroz, ABM
AF Williams, G
Perez-Gonzalez, LA
Queiroz, ABM
TI Using a combined blocking procedure to teach color discrimination to a
child with autism
SO JOURNAL OF APPLIED BEHAVIOR ANALYSIS
LA English
DT Article
DE color discrimination; learning disabilities; autism; conditional
discrimination
ID MENTALLY-RETARDED ADULTS; CONDITIONAL DISCRIMINATION
AB A combined blocking procedure was used to teach a child with autism to select two colors on request. First, two color cards were placed at fixed locations on a table and the experimenter repeatedly requested the child to touch one of the colors. After 10 consecutive correct selections, the child was asked to touch the other color. Blocks of trials with each color were systematically thinned until requests were presented randomly with few errors. Subsequently, the location of the selection cards was systematically alternated until the child was able to touch the correct card when both requests and card positions were presented in random fashion.
C1 Appl Behav Consultant Serv Inc, Englewood, NJ 07631 USA.
Univ Oviedo, Dept Psicol, Oviedo 33003, Spain.
RP Williams, G (reprint author), Appl Behav Consultant Serv Inc, 66 Regency Circle, Englewood, NJ 07631 USA.
EM gladyswilliams2003@hotmail.com; laperez@uniovi.es
RI Perez-Gonzalez, Luis/L-2338-2014
CR Perez-Gonzalez LA, 2002, AM J MENT RETARD, V107, P293, DOI 10.1352/0895-8017(2002)107<0293:MPTTCD>2.0.CO;2
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SMEETS PM, 1994, Q J EXP PSYCHOL-B, V47, P241
NR 5
TC 10
Z9 11
PU JOURNAL APPL BEHAV ANAL
PI LAWRENCE
PA DEPT HUMAN DEVELOPMENT, UNIV KANSAS, LAWRENCE, KS 66045 USA
SN 0021-8855
J9 J APPL BEHAV ANAL
JI J. Appl. Behav. Anal.
PD WIN
PY 2005
VL 38
IS 4
BP 555
EP 558
DI 10.1901/jaba.2005.65-04
PG 4
WC Psychology, Clinical
SC Psychology
GA 991KI
UT WOS:000233812500013
PM 16463537
ER
PT J
AU Fombonne, E
AF Fombonne, E
TI The changing epidemiology of autism
SO JOURNAL OF APPLIED RESEARCH IN INTELLECTUAL DISABILITIES
LA English
DT Article; Proceedings Paper
CT 12th World Congress of the
International-Association-for-the-Scientific-Study-of-Intellectual-Disab
ilities
CY JUN 14-19, 2004
CL Montpellier, FRANCE
SP Int Assoc Sci Study Intellectual Disabil
DE asperger disorder; autism; childhood disintegrative disorder;
epidemiology; incidence; pervasive developmental disorder; prevalence
ID PERVASIVE DEVELOPMENTAL DISORDERS; INFANTILE-AUTISM; CHILDHOOD AUTISM;
PRESCHOOL-CHILDREN; TOTAL POPULATION; SPECTRUM DISORDER;
ASPERGER-SYNDROME; HIGH PREVALENCE; JAPAN; FRENCH
AB This article reviews epidemiological studies of autism and related disorders. Study designs and sample characteristics are summarized. Currently, conservative prevalence estimates are: 13/10000 for autistic disorder, 21/10000 for pervasive developmental disorders not otherwise specified, 2.6/10000 for Asperger disorder, and 2/100000 for childhood disintegrative disorder. Newer surveys suggest that the best estimate for the prevalence of all autistic spectrum disorders is close to 0.6%. A detailed analysis of time trends in rates of pervasive developmental disorders in then provided. It is concluded that most of the increase is accounted for by changes in diagnostic concepts and criteria, and by improved identification. Whether or not there is, in addition to these factors, a true increase in the incidence of the disorder cannot be examined from available data.
C1 McGill Univ, Dept Psychiat, Montreal Childrens Hosp, Canada Res Chair Child Psychiat, Montreal, PQ H3Z 1P2, Canada.
RP Fombonne, E (reprint author), McGill Univ, Dept Psychiat, Montreal Childrens Hosp, Canada Res Chair Child Psychiat, 4018 St Catherine St W, Montreal, PQ H3Z 1P2, Canada.
EM eric.fombonne@mcgill.ca
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NR 71
TC 110
Z9 113
PU BLACKWELL PUBLISHING
PI OXFORD
PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND
SN 1360-2322
J9 J APPL RES INTELLECT
JI J. Appl. Res. Intellect. Disabil.
PD DEC
PY 2005
VL 18
IS 4
BP 281
EP 294
DI 10.1111/j.1468-3148.2005.00266.x
PG 14
WC Psychology, Educational; Rehabilitation
SC Psychology; Rehabilitation
GA 982GE
UT WOS:000233145300002
ER
PT J
AU Minshew, NJ
AF Minshew, NJ
TI Untitled
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Editorial Material
ID WORKING-MEMORY; AUTISM; FMRI
C1 Univ Pittsburgh, Sch Med, Pittsburgh, PA 15213 USA.
RP Minshew, NJ (reprint author), Univ Pittsburgh, Sch Med, 3811 OHara St, Pittsburgh, PA 15213 USA.
CR BEHRMANN M, 2005, IN PRESS NEUROPSYCOL
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Minshew NJ, 1999, NEUROLOGY, V52, P917
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NR 6
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD DEC
PY 2005
VL 35
IS 6
BP 687
EP 693
DI 10.1007/s10803-005-0038-1
PG 7
WC Psychology, Developmental
SC Psychology
GA 003AG
UT WOS:000234653400001
ER
PT J
AU Lord, C
Wagner, A
Rogers, S
Szatmari, P
Aman, M
Charman, T
Dawson, G
Durand, VM
Grossman, L
Guthrie, D
Harris, S
Kasari, C
Marcus, L
Murphy, S
Odom, S
Pickles, A
Scahill, L
Shaw, E
Siegel, B
Sigman, M
Stone, W
Smith, T
Yoder, P
AF Lord, C
Wagner, A
Rogers, S
Szatmari, P
Aman, M
Charman, T
Dawson, G
Durand, VM
Grossman, L
Guthrie, D
Harris, S
Kasari, C
Marcus, L
Murphy, S
Odom, S
Pickles, A
Scahill, L
Shaw, E
Siegel, B
Sigman, M
Stone, W
Smith, T
Yoder, P
TI Challenges in evaluating psychosocial interventions for autistic
spectrum disorders
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
ID INTENSIVE BEHAVIORAL TREATMENT; YOUNG-CHILDREN; CLINICAL-TRIALS;
DEVELOPMENTAL DISORDER; PRESCHOOL-CHILDREN; PROGRAM; ISSUES;
RISPERIDONE; MULTISITE; OUTCOMES
AB In 2002, the National Institutes of Health sponsored a meeting concerning methodological challenges of research in psychosocial interventions in Autism Spectrum Disorders. This paper provides a summary of the presentations and the discussions that occurred during this meeting. Recommendations to federal and private agencies included the need for randomized clinical trials of comprehensive interventions for autism as the highest, but not the sole priority. Ongoing working groups were proposed to address psychosocial interventions with a focus on relevant statistics, standardized documentation and methods of diagnosis, development of outcome measures, establishment of standards in research; and the need for innovative treatment designs, including application of designs from other research areas to the study of interventions in ASD.
C1 Univ Michigan, Autism & Commun Disorder Ctr, Ann Arbor, MI 48109 USA.
NIMH, Child & Adolescent Psychosocial Intervent Program, Bethesda, MD 20892 USA.
Univ Calif Davis, Tulare, CA USA.
McMaster Univ, Hamilton, ON, Canada.
Ohio State Univ, Columbus, OH 43210 USA.
UCL, Inst Child Hlth, London, England.
Univ Washington, Seattle, WA 98195 USA.
Univ S Florida, St Petersburg, FL 33701 USA.
Autism Soc Amer, Bethesda, MD USA.
Univ Calif Los Angeles, Los Angeles, CA USA.
Rutgers State Univ, New Brunswick, NJ 08903 USA.
Univ N Carolina, NECTAS, Chapel Hill, NC USA.
Indiana Univ, Indianapolis, IN 46204 USA.
Univ Manchester, Manchester, Lancs, England.
Yale Univ, New Haven, CT USA.
Univ Calif San Francisco, San Francisco, CA 94143 USA.
Vanderbilt Univ, Kennedy Ctr, Nashville, TN USA.
Univ Rochester, Rochester, NY 14627 USA.
RP Lord, C (reprint author), Univ Michigan, Autism & Commun Disorder Ctr, 1111 E Catherine St, Ann Arbor, MI 48109 USA.
EM celord@umich.edu
RI Durand, V Mark/G-6157-2010; Pickles, Andrew/A-9625-2011; Charman,
Tony/A-2085-2014
OI Pickles, Andrew/0000-0003-1283-0346; Charman, Tony/0000-0003-1993-6549
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NR 63
TC 136
Z9 136
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD DEC
PY 2005
VL 35
IS 6
BP 695
EP 708
DI 10.1007/s10803-005-0017-6
PG 14
WC Psychology, Developmental
SC Psychology
GA 003AG
UT WOS:000234653400002
PM 16496206
ER
PT J
AU Erickson, CA
Stigler, KA
Corkins, MR
Posey, DJ
Fitzgerald, JF
McDougle, CJ
AF Erickson, CA
Stigler, KA
Corkins, MR
Posey, DJ
Fitzgerald, JF
McDougle, CJ
TI Gastrointestinal factors in autistic disorder: A critical review
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Review
DE autistic disorder; gastroenterology; pathophysiology
ID PERVASIVE DEVELOPMENTAL DISORDER; PLACEBO-CONTROLLED TRIAL;
LYMPHOID-NODULAR HYPERPLASIA; INFLAMMATORY-BOWEL-DISEASE; DOUBLE-BLIND;
PORCINE SECRETIN; LYMPHONODULAR HYPERPLASIA; NONSPECIFIC COLITIS;
CELIAC-DISEASE; MEASLES-VIRUS
AB Interest in the gastrointestinal (GI) factors of autistic disorder (autism) has developed from descriptions of symptoms such as constipation and diarrhea in autistic children and advanced towards more detailed studies of GI histopathology and treatment modalities. This review attempts to critically and comprehensively analyze the literature as it applies to all aspects of GI factors in autism, including discussion of symptoms, pathology, nutrition, and treatment. While much literature is available on this topic, a dearth of rigorous study was found to validate GI factors specific to children with autism.
C1 Indiana Univ, Sch Med, Dept Psychiat, Indianapolis, IN 46202 USA.
Indiana Univ, Sch Med, Dept Pediat, Indianapolis, IN 46202 USA.
James Whitcomb Riley Hosp Children, Indianapolis, IN 46202 USA.
RP McDougle, CJ (reprint author), Indiana Univ, Sch Med, Dept Psychiat, Psychiat Bldg A305,1111 W 10th St, Indianapolis, IN 46202 USA.
EM cmcdougl@iupui.edu
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NR 72
TC 65
Z9 68
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD DEC
PY 2005
VL 35
IS 6
BP 713
EP 727
DI 10.1007/s10803-005-0019-4
PG 15
WC Psychology, Developmental
SC Psychology
GA 003AG
UT WOS:000234653400004
PM 16267642
ER
PT J
AU Edgin, JO
Pennington, BF
AF Edgin, JO
Pennington, BF
TI Spatial cognition in autism spectrum disorders: Superior, impaired, or
just intact?
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE autism; Asperger's syndrome; spatial cognition; executive function;
central coherence.
ID HIGH-FUNCTIONING PERSONS; WORKING-MEMORY DEFICIT; WEAK CENTRAL
COHERENCE; EXECUTIVE FUNCTION; ASPERGER-SYNDROME; ADAPTIVE-BEHAVIOR;
YOUNG-CHILDREN; FRONTAL-LOBE; INDIVIDUALS; MIND
AB The profile of spatial ability is of interest across autism spectrum disorders (ASD) because of reported spatial strengths in ASD and due to the recent association of Asperger's syndrome with Nonverbal Learning Disability. Spatial functions were examined in relation to two cognitive theories in autism: the central coherence and executive function (EF) theories. Performance on spatial tasks, EFs, and global/local processing was compared in children with ASD and controls. While the ASD group had faster reaction times on the Embedded Figures task, spatial performance was intact, but not superior, on other tasks. There was no evidence for impairments in EF or in processing global/local information, therefore contradicting these two theories. The implications of these results for these two theories are discussed.
C1 Univ Denver, Denver, CO USA.
RP Edgin, JO (reprint author), Univ Canterbury, Dept Educ, Private Bag 4800, Christchurch 1, New Zealand.
EM edgin@slingshot.co.nz
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NR 74
TC 70
Z9 71
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD DEC
PY 2005
VL 35
IS 6
BP 729
EP 745
DI 10.1007/s10803-005-0020-y
PG 17
WC Psychology, Developmental
SC Psychology
GA 003AG
UT WOS:000234653400005
PM 16328713
ER
PT J
AU Williams, DL
Goldstein, G
Carpenter, PA
Minshew, NJ
AF Williams, DL
Goldstein, G
Carpenter, PA
Minshew, NJ
TI Verbal spatial working memory in autism
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE autism; working memory; information processing
ID HIGH-FUNCTIONING AUTISM; EXECUTIVE FUNCTION; DIAGNOSTIC INTERVIEW;
NEOCORTICAL SYSTEMS; INDIVIDUALS; INTACT; MIND; COMPREHENSION;
DYSFUNCTION; DISORDERS
AB Verbal and spatial working memory were examined in high-functioning children, adolescents, and adults with autism compared to age and cognitive-matched controls. No deficit was found in verbal working memory in the individuals with autism using an N-back letter task and standardized measures. The distinction between the N-back task and others used previously to infer a working memory deficit in autism is that this task does not involve a complex cognitive demand. Deficits were found in spatial working memory. Understanding the basis for the dissociation between intact verbal working memory and impaired spatial working memory and the breakdown that occurs in verbal working memory as information processing demands are increased will likely provide valuable insights into the neural basis of autism.
C1 Univ Pittsburgh, Sch Med, Pittsburgh, PA 15213 USA.
Univ Pittsburgh, VA Pittsburgh Healthcare Syst, Sch Med, Pittsburgh, PA 15213 USA.
Carnegie Mellon Univ, Pittsburgh, PA 15213 USA.
RP Minshew, NJ (reprint author), Univ Pittsburgh, Sch Med, Webster Hall,Suite 300,3811 OHara St, Pittsburgh, PA 15213 USA.
EM minshewnj@upmc.edu
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NR 48
TC 60
Z9 60
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD DEC
PY 2005
VL 35
IS 6
BP 747
EP 756
DI 10.1007/s10803-005-0021-x
PG 10
WC Psychology, Developmental
SC Psychology
GA 003AG
UT WOS:000234653400006
PM 16267641
ER
PT J
AU Fisher, N
Happe, F
AF Fisher, N
Happe, F
TI A training study of theory of mind and executive function in children
with autistic spectrum disorders
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE autism; theory of mind; executive function; intervention
ID TEACHING THEORY; FALSE BELIEF; INTERVENTION; DECEPTION; STATES
AB This study investigated the relationship between theory of mind and executive functioning in children with autistic spectrum disorders through a training study. Ten children were trained on theory of mind, whilst ten were trained in executive function. Seven children were assigned to a control group, receiving no intervention. Training programmes were administered individually, lasting for 25 minutes per day for 5-10 days. Children were tested before training, after training and at a two-month follow-up. Significant improvements were seen in performance on theory of mind tasks in both trained groups, whilst the control group showed no improvement. No improvement on the executive function tasks was seen in any of the groups. The implications of these findings are discussed.
C1 Kings Coll London, Dept Psychol, Inst Psychiat, London SE5 8AF, England.
RP Fisher, N (reprint author), Kings Coll London, Dept Psychol, Inst Psychiat, PO 78, London SE5 8AF, England.
EM n.fisher@iop.kcl.ac.uk
RI Happe, Francesca/D-5544-2012
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NR 39
TC 62
Z9 66
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD DEC
PY 2005
VL 35
IS 6
BP 757
EP 771
DI 10.1007/s10803-005-0022-9
PG 15
WC Psychology, Developmental
SC Psychology
GA 003AG
UT WOS:000234653400007
PM 16283087
ER
PT J
AU Gross, TF
AF Gross, TF
TI Global-local precedence in the perception of facial age and emotional
expression by children with autism and other developmental disabilities
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE autism; face perception; global processing
ID HIGH-FUNCTIONING AUTISM; FACE-RECOGNITION; MENTAL-RETARDATION;
UNFAMILIAR FACES; YOUNG-CHILDREN; DISORDER; EYES; DISCRIMINATION;
ADOLESCENTS; INFORMATION
AB Global information processing and perception of facial age and emotional expression was studied in children with autism, language disorders, mental retardation, and a clinical control group. Children were given a global-local task and asked to recognize age and emotion in human and canine faces. Children with autism made fewer global responses and more errors when recognizing human and canine emotions and canine age than children without autism. Significant relationships were found between global information processing and the recognition of human and canine emotions and canine age. Results are discussed with respect to the relationship between global information processing and face perception and neural structures underlying these abilities.
C1 Univ Redlands, Dept Psychol, Redlands, CA 92373 USA.
RP Gross, TF (reprint author), Univ Redlands, Dept Psychol, 1200 Colton Ave,POB 3080, Redlands, CA 92373 USA.
EM thomas_gross@redlands.edu
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NR 79
TC 16
Z9 16
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD DEC
PY 2005
VL 35
IS 6
BP 773
EP 785
DI 10.1007/s10803-005-0023-8
PG 13
WC Psychology, Developmental
SC Psychology
GA 003AG
UT WOS:000234653400008
PM 16283086
ER
PT J
AU Heaton, P
AF Heaton, P
TI Interval and contour processing in autism
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE autism; pitch processing; global processing; music
ID CONGENITAL AMUSIA; CENTRAL COHERENCE; AUDITORY-CORTEX; PITCH;
PERCEPTION; INDIVIDUALS; INFORMATION; DISORDER; CHILDREN; ABILITY
AB High functioning children with autism and age and intelligence matched controls participated in experiments testing perception of pitch intervals and musical contours. The finding from the interval study showed superior detection of pitch direction over small pitch distances in the autism group. On the test of contour discrimination no group differences emerged. These findings confirm earlier studies showing facilitated pitch processing and a preserved ability to represent small-scale musical structures in autism.
C1 Univ London Goldsmiths Coll, Dept Psychol, London SE14 6NW, England.
RP Heaton, P (reprint author), Univ London Goldsmiths Coll, Dept Psychol, New Cross, London SE14 6NW, England.
EM P.Heaton@gold.ac.uk
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NR 34
TC 37
Z9 38
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD DEC
PY 2005
VL 35
IS 6
BP 787
EP 793
DI 10.1007/s10803-005-0024-7
PG 7
WC Psychology, Developmental
SC Psychology
GA 003AG
UT WOS:000234653400009
PM 16283085
ER
PT J
AU Lecavalier, L
AF Lecavalier, L
TI An evaluation of the Gilliam Autism Rating Scale
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE autism; rating scale; construct validity; factor analysis; diagnosis;
children
ID PDD BEHAVIOR INVENTORY; SCREENING QUESTIONNAIRE; SPECTRUM DISORDERS;
CHECKLIST; CHILDREN; INDIVIDUALS; INSTRUMENTS; COEFFICIENT; DIAGNOSIS;
VALIDITY
AB The Gilliam Autism Rating Scale was developed to identify individuals with autism in research 14 and clinical settings. It has benefited from wide use and acceptance but has received little empirical attention. The purpose of this study was to evaluate the construct and diagnostic validity, interrater reliability, and effects of participant characteristics of the GARS in a large and heterogeneous sample of children and adolescents with autism spectrum disorders. 360 14 parent and teacher ratings were submitted to factor analysis. A three-factor solution explaining 38% of the variance was obtained. Almost half of all items loaded on a Repetitive and Stereotyped Behavior factor. The Developmental Disturbance subscale did not contribute 14 to the Autism Quotient (AQ) and was poorly related to other subscales. Internal consistency for the three behavioral subscales was good but low for the Developmental Disturbance subscale. The average AQ was significantly lower than what was reported in the test manual, suggesting low sensitivity with the current cutoff criteria. Interrater reliability was also much lower than originally reported by the instrument's developer. No significant age or gender effects were found. Level of impairment, as measured by adaptive behavior, was negatively related to total and subscale scores. The implications of these findings were discussed, as was the use of diagnostic instruments in the field in general.
C1 Ohio State Univ, Dept Psychol, Columbus, OH 43210 USA.
Ohio State Univ, Nisonger Ctr, Columbus, OH 43210 USA.
RP Lecavalier, L (reprint author), Ohio State Univ, Dept Psychol, 305 McCampbell Hall,1581 Dodd Dr, Columbus, OH 43210 USA.
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NR 28
TC 31
Z9 31
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD DEC
PY 2005
VL 35
IS 6
BP 795
EP 805
DI 10.1007/s10803-005-0025-6
PG 11
WC Psychology, Developmental
SC Psychology
GA 003AG
UT WOS:000234653400010
PM 16283084
ER
PT J
AU Baron-Cohen, S
Wheelwright, S
Robinson, J
Woodbury-Smith, M
AF Baron-Cohen, S
Wheelwright, S
Robinson, J
Woodbury-Smith, M
TI The Adult Asperger Assessment (AAA): A diagnostic method
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Asperger syndrome (AS); Adult Asperger Assessment (AAA); Autism Spectrum
Quotient (AQ); Empathy Quotient (EQ)
ID SYNDROME/HIGH-FUNCTIONING AUTISM; LIFELONG ECCENTRICITY;
SOCIAL-ISOLATION; CHILDREN; INTERVIEW; QUOTIENT; VALIDITY; DISORDER; AQ
AB At the present time there are a large number of adults who have suspected Asperger syndrome (AS). In this paper we describe a new instrument, the Adult Asperger Assessment (AAA), developed in our clinic for adults with AS. The need for a new instrument relevant to the diagnosis of AS in adulthood arises because existing instruments are designed for use with children. Properties of the AAA include (1) being electronic, data-based, and computer-scorable; (2) linking with two screening instruments [the Autism Spectrum Quotient (AQ) and the Empathy Quotient (EQ)]; and (3) employing a more stringent set of diagnostic criteria than DSM-IV, in order to avoid false positives. The AAA is described, and its use with a series of n = 42 clinic-patients is reported. Thirty-seven of these (88%) met DSM-IV criteria, but only 34 of these (80%) met AAA criteria. The AAA is therefore more conservative than DSM-IV.
C1 Univ Cambridge, Autism Res Ctr, Dept Psychiat, Cambridge CB2 2AH, England.
RP Baron-Cohen, S (reprint author), Univ Cambridge, Autism Res Ctr, Dept Psychiat, Douglas House,18b Trumpington Rd, Cambridge CB2 2AH, England.
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NR 36
TC 55
Z9 55
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD DEC
PY 2005
VL 35
IS 6
BP 807
EP 819
DI 10.1007/s10803-005-0026-5
PG 13
WC Psychology, Developmental
SC Psychology
GA 003AG
UT WOS:000234653400011
PM 16331530
ER
PT J
AU Berument, SK
Starr, E
Pickles, A
Tomlins, M
Papanikolauou, K
Lord, C
Rutter, M
AF Berument, SK
Starr, E
Pickles, A
Tomlins, M
Papanikolauou, K
Lord, C
Rutter, M
TI Pre-linguistic autism diagnostic observation schedule adapted for older
individuals with severe to profound mental retardation: A pilot study
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE autism; diagnosis; mental retardation
ID CHILDREN; BEHAVIOR; DISORDERS; SCALE
AB The Autism Diagnostic Observational Schedule (ADOS) is a semi-structured observational scale developed to assess social interaction, communication and play in individuals who are suspected to have autism. Since the ADOS is not suitable to be used with severely or profoundly mentally retarded adolescents and adults with very limited language skills, materials and some of the tasks of the PL-ADOS and the original ADOS (the former versions of the current ADOS) were adapted. Results indicated that almost all of the overall ratings showed good reliability and discriminative diagnostic validity. Furthermore, the combination of codings into an overall algorithm score on social/communicative behavior resulted in a sensitivity of .82 and a specificity of .85 when using a cut-off score of 15.
C1 Middle E Tech Univ, Dept Psychol, TR-06531 Ankara, Turkey.
Univ Windsor, Fac Educ, Windsor, ON N9B 3P4, Canada.
Univ Manchester, Sch Epidemiol & Hlth Sci, Manchester, Lancs, England.
Child Hlth & Dev Serv, Canberra, ACT, Australia.
Agia Sophia Childrens Hosp, Athens, Greece.
Univ Michigan, Autism & Commun Disorders Ctr, Ann Arbor, MI 48109 USA.
Inst Psychiat, Social Genet & Dev Psychiat Res Ctr, London, England.
RP Berument, SK (reprint author), Middle E Tech Univ, Dept Psychol, TR-06531 Ankara, Turkey.
EM sibel@metu.edu.tr
RI Pickles, Andrew/A-9625-2011; Rutter, Michael/C-8570-2013
OI Pickles, Andrew/0000-0003-1283-0346;
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NR 18
TC 11
Z9 11
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD DEC
PY 2005
VL 35
IS 6
BP 821
EP 829
DI 10.1007/s10803-005-0027-4
PG 9
WC Psychology, Developmental
SC Psychology
GA 003AG
UT WOS:000234653400012
PM 16283083
ER
PT J
AU Grindle, CF
Remington, B
AF Grindle, CF
Remington, B
TI Teaching children with autism when reward delayed. The effects of two
kinds of marking stimuli
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE applied behavior analysis; associative learning; attention; delayed
reinforcement; discrete-trial training; response marking
ID CONDITIONED CUE-VALUE; BEHAVIORAL TREATMENT; EARLY INTERVENTION;
RESPONSE-MARKING; HYPOTHESIS
AB Three children with autism were taught to identify pictures of emotions in response to their spoken names. Their speed of acquisition was compared using a within-child alternating treatments design across three teaching conditions, each involving a 5 second delay to reinforcement. In the marked-before condition, an instruction encouraged the children to visually orient to the cards before they made their choice response; in the marked-after condition, an attention-eliciting verbal cue (e.g., "Look!") was delivered after both correct and incorrect responses; in the delay condition, these marking cues were omitted. Performance in the no-cue control was inferior to both the marked-before and marked-after conditions, but the difference between the latter two conditions was not significant.
C1 Univ Southampton, Sch Psychol, Southampton S017 1BJ, Hants, England.
RP Remington, B (reprint author), Univ Southampton, Sch Psychol, Southampton S017 1BJ, Hants, England.
EM R.E.Remington@soton.ac.uk
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NR 40
TC 3
Z9 3
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD DEC
PY 2005
VL 35
IS 6
BP 839
EP 850
DI 10.1007/s10083-005-0029-2
PG 12
WC Psychology, Developmental
SC Psychology
GA 003AG
UT WOS:000234653400014
PM 16283081
ER
PT J
AU Gibson, E
Reed, P
AF Gibson, E
Reed, P
TI Stimulus over-selectivity in rats
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE autism; overselectivity; conditioning; memory; rats
ID MULTIPLE VISUAL CUES; AUTISTIC-CHILDREN; MODELS
AB The present study explored whether a similar phenomenon to stimulus over-selectivity occurred in rats, in the hope of establishing a non-human model for the autism. Rats were serially presented with two-15 seconds, two-element compound stimuli prior to the delivery of food, in an appetitive classical conditioning procedure. Each compound stimulus consisted of two lights. Once the rats had acquired a conditioned response (CR) to the stimuli, they were presented with each of the component elements separately in extinction. The rats demonstrated greater conditioning to components of the compound presented just prior to reinforcement than to the components of the temporally distant compound. However, there was a smaller difference between CRs to the components of the compound presented just prior to reinforcement (i.e. less overshadowing) than between the components of the temporally distant compound. It is suggested that rats demonstrated a form of stimulus over-selectivity, resulting in greater overshadowing of one cue by another. Such results may form the basis of a viable non-human model of this symptom of autistic spectrum disorder.
C1 Univ Coll Swansea, Dept Psychol, Swansea SA2 8PP, W Glam, Wales.
Univ London St Georges Hosp, London SW17 0RE, England.
RP Reed, P (reprint author), Univ Coll Swansea, Dept Psychol, Singleton Pk, Swansea SA2 8PP, W Glam, Wales.
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NR 21
TC 8
Z9 8
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD DEC
PY 2005
VL 35
IS 6
BP 851
EP 859
DI 10.1007/s10803-005-0030-9
PG 9
WC Psychology, Developmental
SC Psychology
GA 003AG
UT WOS:000234653400015
PM 16341822
ER
PT J
AU Paul, R
Shriberg, LD
McSweeny, J
Cicchetti, D
Klin, A
Volkmar, F
AF Paul, R
Shriberg, LD
McSweeny, J
Cicchetti, D
Klin, A
Volkmar, F
TI Brief report: Relations between prosodic performance and communication
and socialization ratings in high functioning speakers with autism
spectrum disorders
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE prosody; autism; Asperger syndrome; communication; socialization
ID ADAPTIVE-BEHAVIOR SCALES; FOLLOW-UP; INFANTILE-AUTISM; FIELD TRIAL;
DSM-IV; SPEECH; RELIABILITY; DEFICITS; ADULTS
AB Shriberg et al. [Shriberg, L. et al. (2001). Journal of Speech, Language and Hearing Research, 44, 1097-1115] described prosody-voice features of 30 high functioning speakers with autistic spectrum disorder (ASD) compared to age-matched control speakers. The present study reports additional information on the speakers with ASD, including associations among prosody-voice variables and ratings of communication social abilities. Results suggest that the inappropriate sentential stress and hypernasality previously identified in some of these speakers is related to communication/sociability ratings. These findings and associated trends are interpreted to indicate important links between prosodic performance and social and communicative competence. They suggest the need for careful assessment of inappropriate prosody and voice features in speakers with ASD, and for effective intervention programs aimed at reducing the stigmatization of individuals with these conditions.
C1 Yale Univ, Ctr Child Study, New Haven, CT 06520 USA.
So Connecticut State Univ, New Haven, CT 06515 USA.
Univ Wisconsin, Madison, WI USA.
RP Paul, R (reprint author), Yale Univ, Ctr Child Study, POB 207900, New Haven, CT 06520 USA.
EM rhea.paul@yale.edu
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NR 40
TC 45
Z9 45
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD DEC
PY 2005
VL 35
IS 6
BP 861
EP 869
DI 10.1007/s10803-005-0031-8
PG 9
WC Psychology, Developmental
SC Psychology
GA 003AG
UT WOS:000234653400016
PM 16283080
ER
PT J
AU Shea, V
AF Shea, V
TI Lumpers, sputters, and Asperger syndrome
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Letter
ID CLINICAL SYMPTOMS; CLUSTER-ANALYSIS; DISORDER; AUTISM; SUBTYPES;
CHILDREN
C1 Univ N Carolina, Div TEACCH, Chapel Hill, NC 27599 USA.
RP Shea, V (reprint author), Univ N Carolina, Div TEACCH, 1506 E Franklin,Suite 202, Chapel Hill, NC 27599 USA.
EM victoria.shea@mindspring.com
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YIRMIYA N, 1991, CLIN PSYCHOL REV, V11, P669, DOI 10.1016/0272-7358(91)90125-E
NR 19
TC 4
Z9 4
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD DEC
PY 2005
VL 35
IS 6
BP 871
EP 872
DI 10.1007/s10803-005-0032-7
PG 2
WC Psychology, Developmental
SC Psychology
GA 003AG
UT WOS:000234653400017
PM 16283079
ER
PT J
AU Hollander, E
Soorya, L
Wasserman, S
Anagnostou, E
Esposito, K
Chaplin, W
Dell'Osso, B
AF Hollander, E
Soorya, L
Wasserman, S
Anagnostou, E
Esposito, K
Chaplin, W
Dell'Osso, B
TI Divalproex sodium versus placebo in the treatment of repetitive
behaviors and the treatment of activation associated with fluoxetine in
autism spectrum disorder
SO JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY
LA English
DT Meeting Abstract
CT 45th Annual Meeting of the New-Clinical-Drug-Evaluation-Unit
CY JUN 06-09, 2005
CL Boca Raton, FL
SP NIMH, New Clin Drug Evaluat Unit
C1 Mt Sinai Sch Med, New York, NY USA.
NR 0
TC 0
Z9 0
PU MARY ANN LIEBERT INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1044-5463
J9 J CHILD ADOL PSYCHOP
JI J. Child Adolesc. Psychopharmacol.
PD DEC
PY 2005
VL 15
IS 6
BP 857
EP 858
PG 2
WC Pediatrics; Pharmacology & Pharmacy; Psychiatry
SC Pediatrics; Pharmacology & Pharmacy; Psychiatry
GA 000EC
UT WOS:000234442700022
ER
PT J
AU Hellings, JA
Nickel, EJ
Weckbaugh, M
Hall, S
Reese, M
Cain, SE
Schroeder, SR
Cook, EH
AF Hellings, JA
Nickel, EJ
Weckbaugh, M
Hall, S
Reese, M
Cain, SE
Schroeder, SR
Cook, EH
TI Valproate for aggression in youth with autism spectrum disorders
SO JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY
LA English
DT Meeting Abstract
CT 45th Annual Meeting of the New-Clinical-Drug-Evaluation-Unit
CY JUN 06-09, 2005
CL Boca Raton, FL
SP NIMH, New Clin Drug Evaluat Unit
C1 Univ Kansas, Med Ctr, Kansas City, KS 66103 USA.
Univ Kansas, Kansas City, MO USA.
Univ Chicago, Chicago, IL 60637 USA.
NR 0
TC 0
Z9 0
PU MARY ANN LIEBERT INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1044-5463
J9 J CHILD ADOL PSYCHOP
JI J. Child Adolesc. Psychopharmacol.
PD DEC
PY 2005
VL 15
IS 6
BP 861
EP 862
PG 2
WC Pediatrics; Pharmacology & Pharmacy; Psychiatry
SC Pediatrics; Pharmacology & Pharmacy; Psychiatry
GA 000EC
UT WOS:000234442700029
ER
PT J
AU Aman, MG
Arnold, LE
McDougle, CJ
Vitiello, B
Scahill, L
Davies, M
McCracken, JT
Tierney, E
Nash, PL
Posey, DJ
Chuang, S
Martin, A
Shah, B
Gonzalez, NM
Swiezy, NB
Ritz, L
Koenig, K
McGough, J
Ghuman, JK
Lindsay, RL
AF Aman, MG
Arnold, LE
McDougle, CJ
Vitiello, B
Scahill, L
Davies, M
McCracken, JT
Tierney, E
Nash, PL
Posey, DJ
Chuang, S
Martin, A
Shah, B
Gonzalez, NM
Swiezy, NB
Ritz, L
Koenig, K
McGough, J
Ghuman, JK
Lindsay, RL
TI Acute and long-term safety and tolerability of risperidone in children
with autism
SO JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY
LA English
DT Article
ID DISRUPTIVE BEHAVIOR DISORDERS; PSYCHOACTIVE MEDICINES; INDIVIDUALS;
PATTERNS; PSYCHOPHARMACOLOGY; DISCONTINUATION; PREVALENCE; SOCIETY;
TRIALS; WEIGHT
AB Treatment-emergent adverse events (AEs) were monitored during an 8-week, double-blind, placebo-controlled trial of risperidone (0.5-3.5 mg/day) in 101 children and adolescents with a lifetime diagnosis of autistic disorder. In addition, 37 placebo nonresponders received open-label risperidone for another 8 weeks. Of all the risperidone responders (n = 65), 63 entered an open extension of another 16 weeks (6 months total risperidone exposure), and 32 of them were rerandomized to either continued risperidone therapy (11 = 16) or gradual replacement with placebo (n = 16) over 8 weeks. We collected the following measures of safety and tolerability: (1) laboratory blood assessments (CBC with differential, electrolytes, and liver function tests) and urinalyses, (2) vital signs, (3) Side Effects Review of AEs thought to be associated with risperidone, (4) sleep records, (5) Simpson Angus Neurological Rating Scale (SARS), (6) Abnormal Involuntary Movement Scale (AIMS), and (7) height and weight. No clinically significant changes were found on the lab tests. During the 8-week acute trial, the most common AEs on the Side Effects Review, scored as moderate or higher, were as follows (placebo and risperidone, respectively): Somnolence (12% and 37%), enuresis (29% and 33%), excessive appetite (10% and 33%), rhinitis (8% and 16%), difficulty waking (8% and 12%), and constipation (12% and 10%). "Difficulty falling asleep" and anxiety actually favored the risperidone condition at statistically significant levels. The same AEs tended to recur through 6 months of treatment, although often at reduced levels. Using Centers for Disease Control (CDC) standardized scores, both weight and body mass index (BMI) increased with risperidone during the acute trial (0.5 and 0.6 SDs, respectively, for risperidone; 0.0 and 0.1 SDs, respectively, for placebo) and into open-label extension (0.19 and 0.16 SDs, respectively), although the amount of gain decelerated with time. Extrapyramidal symptoms, as assessed by the SARS, were no more common for drug than placebo, although drooling was reported more often in the risperidone group. There were no differences between groups on the AIMS. Two subjects had seizures (one taking placebo), but these were considered unrelated to active drug. Most AEs were mild to moderate and failed to interfere with therapeutic changes; there were no unanticipated AEs. The side effects of most concern were somnolence and weight gain.
C1 Ohio State Univ, Nisonger Ctr, Columbus, OH 43210 USA.
Indiana Univ, Indianapolis, IN 46204 USA.
NIMH, Bethesda, MD 20892 USA.
Yale Univ, New Haven, CT USA.
Columbia Univ, New York, NY USA.
Univ Calif Los Angeles, Los Angeles, CA USA.
Kennedy Krieger Inst, Baltimore, MD USA.
Childrens Hosp, Columbus, OH 43205 USA.
Arizona Child Study Ctr, Phoenix, AZ USA.
RP Aman, MG (reprint author), Ohio State Univ, Nisonger Ctr, 1581 Dodd Dr, Columbus, OH 43210 USA.
EM aman.1@osu.edu
CR Aman M., 1994, ABERRANT BEHAV CHECK
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NR 25
TC 60
Z9 60
PU MARY ANN LIEBERT INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1044-5463
J9 J CHILD ADOL PSYCHOP
JI J. Child Adolesc. Psychopharmacol.
PD DEC
PY 2005
VL 15
IS 6
BP 869
EP 884
DI 10.1089/cap.2005.15.869
PG 16
WC Pediatrics; Pharmacology & Pharmacy; Psychiatry
SC Pediatrics; Pharmacology & Pharmacy; Psychiatry
GA 000EC
UT WOS:000234442700037
PM 16379507
ER
PT J
AU Rogers, SJ
Ozonoff, S
AF Rogers, SJ
Ozonoff, S
TI Annotation: What do we know about sensory dysfunction in autism? A
critical review of the empirical evidence
SO JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY
LA English
DT Review
DE autism; sensory; arousal; psychophysiology
ID HIGH-FUNCTIONING AUTISM; DEVELOPMENTAL DISORDERS; DIAGNOSTIC INTERVIEW;
REPETITIVE BEHAVIOR; SEROTONIN SYNTHESIS; SPECTRUM DISORDERS;
RETARDED-CHILDREN; MOTOR INTEGRATION; AUDITORY-STIMULI; INFANTILE-AUTISM
AB Background: Unusual responses to sensory stimuli are seen in many children with autism. Their presence was highlighted both in early accounts of autism and in more recent first-person descriptions. There is a widespread belief that sensory symptoms characterize autism and differentiate it from other disorders. This paper examines the empirical evidence for this assumption.
Method: All controlled experimental laboratory investigations published since 1960 were identified through systematic searches using Medline/PubMed and PsycInfo search engines. A total of 48 empirical papers and 27 theoretical or conceptual papers were reviewed.
Results: Sensory symptoms are more frequent and prominent in children with autism than in typically developing children, but there is not good evidence that these symptoms differentiate autism from other developmental disorders. Certain groups, including children with fragile X syndrome and those who are deaf-blind, appear to demonstrate higher rates of sensory symptoms than children with autism. In reviewing the evidence relevant to two theories of sensory dysfunction in autism, over- and under-arousal theory, we find that there is very little support for hyper-arousal and failure of habituation in autism. There is more evidence that children with autism, as a group, are hypo-responsive to sensory stimuli, but there are also multiple failures to replicate findings and studies that demonstrate lack of group differences.
Conclusions: The use of different methods, the study of different sensory modalities, and the changing scientific standards across decades complicate interpretation of this body of work. We close with suggestions for future research in this area.
C1 Univ Calif Davis, Med Ctr, MIND Inst, Sacramento, CA 95817 USA.
Univ Calif Davis, Dept Psychiat & Behav Sci, Sacramento, CA 95817 USA.
RP Rogers, SJ (reprint author), Univ Calif Davis, Med Ctr, MIND Inst, 2825 50th St, Sacramento, CA 95817 USA.
EM sjrogers@ucdavis.edu
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NR 83
TC 161
Z9 161
PU BLACKWELL PUBLISHING
PI OXFORD
PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND
SN 0021-9630
J9 J CHILD PSYCHOL PSYC
JI J. Child Psychol. Psychiatry
PD DEC
PY 2005
VL 46
IS 12
BP 1255
EP 1268
DI 10.1111/j.1469-7610.2005.01431.x
PG 14
WC Psychology, Developmental; Psychiatry; Psychology
SC Psychology; Psychiatry
GA 986JV
UT WOS:000233446800002
PM 16313426
ER
PT J
AU Rausch, JL
Sirota, EL
Londino, DL
Johnson, ME
Carr, BM
Bhatia, R
Miller, S
AF Rausch, JL
Sirota, EL
Londino, DL
Johnson, ME
Carr, BM
Bhatia, R
Miller, S
TI Open-label risperidone for Asperger's disorder: Negative symptom
spectrum response
SO JOURNAL OF CLINICAL PSYCHIATRY
LA English
DT Article; Proceedings Paper
CT 157th Annual Meeting of the American-Psychiatric-Association
CY MAY 01-06, 2004
CL New York, NY
SP Amer Psychiat Assoc
ID PERVASIVE DEVELOPMENTAL DISORDERS; HIGH-FUNCTIONING AUTISM;
SCHIZOPHRENIA; SCALE; HALOPERIDOL; DIAGNOSIS
AB Objective: Asperger's disorder consists of negative symptoms similar to those seen in schizophrenia, autism, schizoid personality disorder, and schizotypal personality disorder. We investigated whether risperidone, which is effective in treating the negative symptoms of schizophrenia, would improve such symptoms observed in Asperger's disorder in a prospective, open-label trial.
Method: Thirteen male patients aged 6 to 18 years who were diagnosed with Asperger's disorder by DSM-IV criteria were enrolled in a 12-week, prospective, open-label pilot study from March 13, 2002 to August 11, 2003. All subjects were started on risperidone 0.25 mg twice per day. Doses were increased based on clinical indication and tolerability. The primary efficacy variable was the Scale for the Assessment of Negative Symptoms (SANS). Each subject's baseline score served as his control. Secondary efficacy measures included the Positive and Negative Syndrome Scale, Brief Psychiatric Rating Scale, Montgomery-Asberg Depression Rating Scale. Global Assessment Scale, and a modified Asperger Syndrome Diagnostic Scale.
Results: We found a statistically significant improvement from baseline for last-observation-carried-forward (LOCF) analyses as well as for analyses of 12-week completers (N = 9) in our primary outcome measure, SANS scores (F = 13.41, p < .0001 for 12-week completers; F = 9.64, p < .0001 for LOCF). We also found statistically significant improvement in all secondary efficacy measurements (F values range, 8.41 to 15.73, p values range, < .0001 to < .005 for 12-week completers; F values range, 6.53 to 7.75, all p < .0001 for LOCF).
Conclusions: Subjects' symptoms significantly improved after risperidone. The open-label nature of this small pilot study suggests caution in interpreting these data, but the results suggest that placebo-controlled trials should follow.
C1 Med Coll Georgia, Dept Psychiat & Hlth Behav, Augusta, GA 30912 USA.
RP Rausch, JL (reprint author), Med Coll Georgia, Dept Psychiat & Hlth Behav, 1515 Pope Ave, Augusta, GA 30912 USA.
EM jeffreyr@mail.mcg.edu
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
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NR 26
TC 14
Z9 14
PU PHYSICIANS POSTGRADUATE PRESS
PI MEMPHIS
PA P O BOX 240008, MEMPHIS, TN 38124 USA
SN 0160-6689
J9 J CLIN PSYCHIAT
JI J. Clin. Psychiatry
PD DEC
PY 2005
VL 66
IS 12
BP 1592
EP 1597
PG 6
WC Psychology, Clinical; Psychiatry
SC Psychology; Psychiatry
GA 999UL
UT WOS:000234415900015
PM 16401163
ER
PT J
AU Vitiello, B
Davies, M
Arnold, LE
McDougle, CJ
Aman, M
McCracken, JT
Scahill, L
Tierney, E
Posey, DJ
Swiezy, NB
Koenig, K
AF Vitiello, B
Davies, M
Arnold, LE
McDougle, CJ
Aman, M
McCracken, JT
Scahill, L
Tierney, E
Posey, DJ
Swiezy, NB
Koenig, K
TI Assessment of the integrity of study blindness in a pediatric clinical
trial of risperidone
SO JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY
LA English
DT Article
ID TREATMENT ASSIGNMENT; PLACEBO; CHILDREN; MEDICATION; IMIPRAMINE;
PATIENT; GUESSES
AB Objective: Controlled clinical trials in pediatric psychopharmacology rely on blinded parents and clinical evaluators for outcome data, but little is known about the success of the masking procedures. The blindness of clinical evaluators and parents was examined in a clinical trial of risperidone in autism.
Methods: Clinical evaluators and parents were asked to guess individual treatment assignments at the end of an 8-week placebo-controlled trial of risperidone in children (aged 5-17 years) with autism. Clinical evaluators did not have access to adverse event data.
Results: The rates of correctly guessing individual treatment assignment (risperidone or placebo) were significantly greater than chance for both clinical evaluators and parents (P < 0.001). Clinical evaluators associated improvement with attribution to risperidone, and lack of improvement with attribution to placebo, in both the risperidone and placebo treatment arms. Parents associated improvement with attribution to risperidone only in the placebo treatment arm. Parents reported that adverse events influenced their guesses, but presence of adverse events was not associated with correctness of guess.
Conclusion: Improvement was associated with attribution to active treatment regardless of actual treatment assignment, and adverse events did not appear to be a threat to study blindness.
C1 NIMH, Div Serv & Intervent Res, Bethesda, MD 20892 USA.
Columbia Univ, New York State Psychiat Inst, New York, NY USA.
Ohio State Univ, Nisonger Ctr, Columbus, OH 43210 USA.
Indiana Univ, Sch Med, Dept Psychiat, Indianapolis, IN 46202 USA.
Univ Calif Los Angeles, Inst Neuropsychiat, Los Angeles, CA 90024 USA.
Yale Univ, Ctr Child Study, New Haven, CT 06520 USA.
Kennedy Krieger Inst, Baltimore, MD USA.
RP Vitiello, B (reprint author), NIMH, Div Serv & Intervent Res, Room 7147,6001 Execut Blvd,MSC 9633, Bethesda, MD 20892 USA.
EM bvitiell@mail.nih.gov
CR Bang HJ, 2004, CONTROL CLIN TRIALS, V25, P143, DOI 10.1016/j.cct.2003.10.016
Basoglu M, 1997, ARCH GEN PSYCHIAT, V54, P744
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Rosman NP, 2001, J PEDIATR-US, V138, P548, DOI 10.1067/mpd.2001.112169
NR 15
TC 3
Z9 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3261 USA
SN 0271-0749
J9 J CLIN PSYCHOPHARM
JI J. Clin. Psychopharmacol.
PD DEC
PY 2005
VL 25
IS 6
BP 565
EP 569
DI 10.1097/01.jcp.0000185426.08268.92
PG 5
WC Pharmacology & Pharmacy; Psychiatry
SC Pharmacology & Pharmacy; Psychiatry
GA 988VC
UT WOS:000233628200011
PM 16282839
ER
PT J
AU Jones, C
Krakowiak, P
Kalamkarian, N
Croen, L
Hertz-Picciotto, I
Hansen, R
AF Jones, C
Krakowiak, P
Kalamkarian, N
Croen, L
Hertz-Picciotto, I
Hansen, R
TI Autism and head circumference in the CHARGE study
SO JOURNAL OF DEVELOPMENTAL AND BEHAVIORAL PEDIATRICS
LA English
DT Meeting Abstract
C1 Univ Calif Davis, Sacramento, CA 95817 USA.
Kaiser Permanente, Oakland, CA USA.
NR 0
TC 0
Z9 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3261 USA
SN 0196-206X
J9 J DEV BEHAV PEDIATR
JI J. Dev. Behav. Pediatr.
PD DEC
PY 2005
VL 26
IS 6
BP 463
EP 463
DI 10.1097/00004703-200512000-00023
PG 1
WC Behavioral Sciences; Psychology, Developmental; Pediatrics
SC Behavioral Sciences; Psychology; Pediatrics
GA 993RZ
UT WOS:000233973900020
ER
PT J
AU Harris, SW
Goodlin-Jones, B
Nowicki, S
Bacalman, S
Tassone, F
Hagerman, RJ
AF Harris, SW
Goodlin-Jones, B
Nowicki, S
Bacalman, S
Tassone, F
Hagerman, RJ
TI Autism profiles of young males with fragile X syndrome
SO JOURNAL OF DEVELOPMENTAL AND BEHAVIORAL PEDIATRICS
LA English
DT Meeting Abstract
C1 Univ Calif Davis, Med Ctr, MIND, Sacramento, CA 95817 USA.
NR 0
TC 0
Z9 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3261 USA
SN 0196-206X
J9 J DEV BEHAV PEDIATR
JI J. Dev. Behav. Pediatr.
PD DEC
PY 2005
VL 26
IS 6
BP 464
EP 464
DI 10.1097/00004703-200512000-00026
PG 1
WC Behavioral Sciences; Psychology, Developmental; Pediatrics
SC Behavioral Sciences; Psychology; Pediatrics
GA 993RZ
UT WOS:000233973900023
ER
PT J
AU Rolland, C
Nanclares-Nogues, V
AF Rolland, C
Nanclares-Nogues, V
TI Parent-therapist implemented, integrated treatment for young children
with autism: A comparison with therapist-implemented
SO JOURNAL OF DEVELOPMENTAL AND BEHAVIORAL PEDIATRICS
LA English
DT Meeting Abstract
C1 Advocate Illinois Mason Med Ctr, Chicago, IL USA.
NR 0
TC 0
Z9 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3261 USA
SN 0196-206X
J9 J DEV BEHAV PEDIATR
JI J. Dev. Behav. Pediatr.
PD DEC
PY 2005
VL 26
IS 6
BP 464
EP 464
DI 10.1097/00004703-200512000-00025
PG 1
WC Behavioral Sciences; Psychology, Developmental; Pediatrics
SC Behavioral Sciences; Psychology; Pediatrics
GA 993RZ
UT WOS:000233973900022
ER
PT J
AU Sciutto, MJ
Cantwell, C
AF Sciutto, MJ
Cantwell, C
TI Factors influencing the differential diagnosis of Asperger's Disorder
and high-functioning autism
SO JOURNAL OF DEVELOPMENTAL AND PHYSICAL DISABILITIES
LA English
DT Article
DE differential diagnosis; Asperger's Disorder; developmental disabilities;
autism
ID CLINICAL SYMPTOMS
AB We examined the influence of a child's IQ level, presence of a language delay, and his desire to engage others in social interaction on clinicians' diagnosis of Asperger's Disorder. Seventy-four clinicians read an excerpt from a fictional psychological report and recommended a primary diagnosis for the child described in the report. Results indicated that presence of a delay in language milestones decreased likelihood but did not rule out an Asperger's diagnosis. In addition, a higher IQ and a desire to engage others in social interaction when combined with an absence of a language delay significantly increased the likelihood of an Asperger's diagnosis. Results of this study suggest that, when presented with a high-functioning child exhibiting symptoms within the autistic spectrum, clinicians do attend to elements of the DSM-IV criteria when considering differential diagnosis, but do so in conjunction with other factors.
C1 Muhlenberg Coll, Dept Psychol, Allentown, PA 18104 USA.
RP Sciutto, MJ (reprint author), Muhlenberg Coll, Dept Psychol, Allentown, PA 18104 USA.
EM sciutto@muhlenberg.edu
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th
Dawes R. M., 1994, HOUSE CARDS PSYCHOL
Eisenmajer R, 1998, J AUTISM DEV DISORD, V28, P527, DOI 10.1023/A:1026004212375
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Volkmar F. R., 2000, ASPERGER SYNDROME, P25
NR 15
TC 5
Z9 5
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1056-263X
J9 J DEV PHYS DISABIL
JI J. Dev. Phys. Disabil.
PD DEC
PY 2005
VL 17
IS 4
BP 345
EP 359
DI 10.1007/s10882-005-6618-3
PG 15
WC Rehabilitation
SC Rehabilitation
GA 997UG
UT WOS:000234273700004
ER
PT J
AU Baker, DJ
Valenzuela, S
Wieseler, NA
AF Baker, DJ
Valenzuela, S
Wieseler, NA
TI Naturalistic inquiry and treatment of coprophagia in one individual
SO JOURNAL OF DEVELOPMENTAL AND PHYSICAL DISABILITIES
LA English
DT Article
DE coprophagia; functional assessment; positive behavior support; autism
ID ADULT
AB Coprophagia refers to the deliberate ingestion of one's fecal matter. This brief report details the naturalistic inquiry, assessment, and treatment of coprophagia in an adult with developmental disabilities and autism. An assessment was completed which identified self-stimulation as the function of the behavior. The intervention consisted of providing highly spiced, flavorful foods with meals and snacks for the person. Frequency of coprophagia decreased, but by a variable amount, for the first 6 months following initiation of the intervention, and then reduced to zero instances for a period of 26 months.
C1 Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Elizabeth M Boggs Ctr Dev Disabil, New Brunswick, NJ 08903 USA.
Partnerships Community Living, Salem, OR USA.
Community Support Serv, Faribault, MN USA.
RP Baker, DJ (reprint author), Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Elizabeth M Boggs Ctr Dev Disabil, 335 George St,POB 2688, New Brunswick, NJ 08903 USA.
EM dan.baker@umdnj.edu
CR BARLOW DH, 1984, SINGLE CASE EXPT DES
BUGLE C, 1993, RES DEV DISABIL, V14, P445, DOI 10.1016/0891-4222(93)90037-K
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NR 15
TC 4
Z9 4
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1056-263X
J9 J DEV PHYS DISABIL
JI J. Dev. Phys. Disabil.
PD DEC
PY 2005
VL 17
IS 4
BP 361
EP 367
DI 10.1007/s10882-005-6619-2
PG 7
WC Rehabilitation
SC Rehabilitation
GA 997UG
UT WOS:000234273700005
ER
PT J
AU Tonn, RT
Obrzut, JE
AF Tonn, RT
Obrzut, JE
TI The neuropsychological perspective on autism
SO JOURNAL OF DEVELOPMENTAL AND PHYSICAL DISABILITIES
LA English
DT Article
DE autistic disorder; asperger's disorder; neuropsychological perspective
on autism; neuropsychological theories of autism
ID BRAIN-DAMAGED PATIENTS; EARLY INFANTILE-AUTISM; EXECUTIVE FUNCTION;
SPECTRUM DISORDER; CHILDREN; DEFICITS; MIND; PERFORMANCE; ABILITY;
ADULTS
AB The purpose of this paper is to integrate the existing neuropsychological research on autism with some of the more recent literature. There is considerable debate concerning the neuropsychological distinction between autism and Asperger's disorder. There is also overwhelming evidence that individuals with autism have neuropsychological impairments across a number of domains, indicating that multiple regions of the brain are likely involved. Some of the impairments common to individuals with autism may be a result of abnormal lateralization. Although the limbic system, central coherence, executive function, and theory of mind hypotheses are helpful in conceptualizing the disorder, it is unlikely that any of them represent "mutually exclusive" abnormalities.
C1 Univ Arizona, Coll Educ, Dept Special Educ & Rehabil, Tucson, AZ 85721 USA.
Univ Alberta, Edmonton, AB T6G 2M7, Canada.
RP Obrzut, JE (reprint author), Univ Arizona, Coll Educ, Dept Special Educ & Rehabil, Tucson, AZ 85721 USA.
EM jobrzut@u.arizona.edu
CR American Psychiatric Association, 2002, DIAGN STAT MAN MENT
Asperger H., 1944, AUTISM ASPERGER SYND, P37
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NR 41
TC 3
Z9 3
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1056-263X
J9 J DEV PHYS DISABIL
JI J. Dev. Phys. Disabil.
PD DEC
PY 2005
VL 17
IS 4
BP 409
EP 419
DI 10.1007/s10882-005-6623-6
PG 11
WC Rehabilitation
SC Rehabilitation
GA 997UG
UT WOS:000234273700008
ER
PT J
AU Woodbury-Smith, MR
Clare, ICH
Holland, AJ
Kearns, A
Staufenberg, E
Watson, P
AF Woodbury-Smith, MR
Clare, ICH
Holland, AJ
Kearns, A
Staufenberg, E
Watson, P
TI A case-control study of offenders with high functioning autistic
spectrum disorders
SO JOURNAL OF FORENSIC PSYCHIATRY & PSYCHOLOGY
LA English
DT Article
DE ASDs; mental disorders; offending; empathy; executive function; theory
of mind
ID PERVASIVE DEVELOPMENTAL DISORDERS; ANTISOCIAL PERSONALITY-DISORDER;
ASPERGERS-SYNDROME; PSYCHOPATHIC INDIVIDUALS; EXPRESSION RECOGNITION;
EXECUTIVE DYSFUNCTION; FEARFUL EXPRESSIONS; CHILDS APPRAISAL; REVISED
VERSION; MIND
AB Although a number of case reports have suggested that some people with autistic spectrum disorders (ASDs) commit criminal offences, and that core cognitive characteristics may be associated with this vulnerability, the possibility has not been investigated. The exploratory study described in this paper examined whether the cognitive impairments of people with ASDs are associated with their vulnerability to offending. Groups of 21 adults with ASDs and a history of offending, 23 adults with ASDs and no history of offending, and a general population group of 23 people without ASDs were compared on established measures of those aspects of cognition known to be impaired in both people with ASDs and offenders: theory of mind, executive function, and emotion recognition. Compared with their non-offending peers, the ASD offenders showed a significantly greater impairment in recognition of emotional expressions of fear, but no difference in theory of mind, executive function, and recognition of facial expressions of sadness. It is proposed that a small group of people with ASDs may be co-morbid for autism and developmental disorders of antisocial behaviour, and that this might be related to their vulnerability to criminal offending.
C1 Univ Cambridge, Dept Psychiat, Cambridge, England.
Chase Farm Hosp, Enfield, Middx, England.
Little Plumstead Hosp, Norwich, Norfolk, England.
MRC, Cognit & Brain Sci Unit, Cambridge, England.
RP Woodbury-Smith, MR (reprint author), Yale Univ, Sch Med, Ctr Child Study, POB 207900,230 S Frontage Rd, New Haven, CT 06520 USA.
EM marc.woodbury-smith@yale.edu
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NR 76
TC 19
Z9 19
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND
SN 1478-9949
J9 J FORENSIC PSYCHI PS
JI J. Forensic Psychiatry Psychol.
PD DEC
PY 2005
VL 16
IS 4
BP 747
EP 763
DI 10.1080/14789940500302554
PG 17
WC Criminology & Penology; Psychiatry
SC Criminology & Penology; Psychiatry
GA 993PI
UT WOS:000233967000010
ER
PT J
AU Trute, B
Hiebert-Murphy, D
AF Trute, B
Hiebert-Murphy, D
TI Predicting family adjustment and parenting stress in childhood
disability services using brief assessment tools
SO JOURNAL OF INTELLECTUAL & DEVELOPMENTAL DISABILITY
LA English
DT Article
DE family adjustment; developmental disability; autism; morale; distress;
childhood disability services
ID YOUNG-CHILDREN; NEEDS; PERCEPTIONS; MOTHERS; FATHERS; QUALITY; NUMBER;
WORK
AB Background The utility of two "psychosocial sensor measures'' was explored for triage use in childhood disability services to detect households at longer-term risk for parent and family distress.
Method Approximately 6 months after entering childhood disability services, mothers and fathers in 111 Canadian families with a young child with a developmental or cognitive disability identified their family service needs and parenting morale. One year later parents completed standardised measures of parenting stress and family adjustment.
Results Two brief measures assessing family counselling needs and parenting morale detected longer-term family maladjustment from the independent perspectives of mothers and fathers. Although mothers' parenting stress in the longer-term was detected by the set of measures, fathers' parenting stress was only detected by their parenting morale.
Conclusions Brief empirical measures with high face validity may facilitate the process of assessment of service needs, and may help in the early identification of families with higher priority for psychosocial family support resources in childhood disability services.
C1 Univ Calgary, Calgary, AB T2N 1N4, Canada.
Univ Manitoba, Winnipeg, MB R3T 2N2, Canada.
RP Trute, B (reprint author), Univ Calgary, 2500 Univ Dr NW, Calgary, AB T2N 1N4, Canada.
EM btrute@ucalgary.ca
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NR 44
TC 17
Z9 17
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 1366-8250
J9 J INTELLECT DEV DIS
JI J. Intellect. Dev. Dis.
PD DEC
PY 2005
VL 30
IS 4
BP 217
EP 225
DI 10.1080/13668250500349441
PG 9
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA 014IS
UT WOS:000235473800004
ER
PT J
AU Trembath, D
Balandin, S
Rossi, C
AF Trembath, D
Balandin, S
Rossi, C
TI Cross-cultural practice and autism
SO JOURNAL OF INTELLECTUAL & DEVELOPMENTAL DISABILITY
LA English
DT Editorial Material
DE cross-cultural practice; autism
ID MULTICULTURAL ISSUES
C1 Univ Sydney, Sch Commun Sci & Disorders, Lidcombe, NSW 1825, Australia.
RP Trembath, D (reprint author), Univ Sydney, Sch Commun Sci & Disorders, POB 170, Lidcombe, NSW 1825, Australia.
EM D.Trembath@fhs.usyd.edu.au
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NR 17
TC 6
Z9 6
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 1366-8250
J9 J INTELLECT DEV DIS
JI J. Intellect. Dev. Dis.
PD DEC
PY 2005
VL 30
IS 4
BP 240
EP 242
DI 10.1080/13668250500349458
PG 3
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA 014IS
UT WOS:000235473800007
ER
PT J
AU Chadwick, O
Cuddy, M
Kusel, Y
Taylor, E
AF Chadwick, O
Cuddy, M
Kusel, Y
Taylor, E
TI Handicaps and the development of skills between childhood and early
adolescence in young people with severe intellectual disabilities
SO JOURNAL OF INTELLECTUAL DISABILITY RESEARCH
LA English
DT Article
DE children; handicaps; intellectual disabilities; longitudinal studies;
skills
ID MENTALLY-RETARDED CHILDREN; ADAPTIVE-BEHAVIOR; DOWNS-SYNDROME;
CAMBERWELL COHORT; FOLLOW-UP; AUTISM; FAMILIES; RISK; AGE
AB While a number of studies have examined the development of skills in children with intellectual disabilities (ID), most have been cross-sectional, most have been concerned with particular syndromes such as Down's syndrome or autism and few have attempted to identify factors associated with improvements in skills.
From a sample of 111 children with severe ID who had been identified from the registers of six special schools at 4-11 years of age, 82 were traced and reassessed 5 years later at the age of 11-17 years. On both occasions, information on the children's handicaps and skills was collected by interviewing their main carers using a shortened version of the Vineland Adaptive Behaviour Scales and the Disability Assessment Schedule.
There were small but statistically significant improvements in Vineland age-equivalent communication and daily living skills scores, but not in Vineland Socialization scores, over the 5-year period of follow-up. This pattern of improvement was observed in most aetiological subgroups. Improvement in skills was greatest in younger children, and was associated with reductions in behaviour problems and in levels of parental stress. In spite of the improvements in age-equivalent scores, Vineland standard scores showed significant declines over the same period of time, indicating that the improvements observed were smaller than would be expected in a general population sample of children of the same age. The dangers of using standard scores or quotients to quantify the level of functioning of children with severe ID are highlighted.
C1 Inst Psychiat, Dept Psychol, London SE5 8AF, England.
RP Chadwick, O (reprint author), Inst Psychiat, Dept Psychol, De Crespigny Pk, London SE5 8AF, England.
EM o.chadwick@iop.kcl.ac.uk
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NR 35
TC 15
Z9 16
PU BLACKWELL PUBLISHING
PI OXFORD
PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND
SN 0964-2633
J9 J INTELL DISABIL RES
JI J. Intell. Disabil. Res.
PD DEC
PY 2005
VL 49
BP 877
EP 888
DI 10.1111/j.1365-2788.2005.00716.x
PN 12
PG 12
WC Education, Special; Genetics & Heredity; Clinical Neurology; Psychiatry;
Rehabilitation
SC Education & Educational Research; Genetics & Heredity; Neurosciences &
Neurology; Psychiatry; Rehabilitation
GA 984NF
UT WOS:000233310900001
PM 16287477
ER
PT J
AU Jacobzone-Leveque, C
Lemonnier, E
Bessaguet, C
Peudonnier, S
Lazartigues, A
Misery, L
AF Jacobzone-Leveque, C
Lemonnier, E
Bessaguet, C
Peudonnier, S
Lazartigues, A
Misery, L
TI Research of skin abnormalities in infantile autism.
SO JOURNAL OF INVESTIGATIVE DERMATOLOGY
LA English
DT Meeting Abstract
CT 2nd Annual Meeting of the Australasian-Society-for-Dermatology-Research
CY MAY 14, 2005
CL Perth, AUSTRALIA
SP Australasian Soc Dermatol Res
C1 Univ Hosp, Dept Dermatol, Brest, France.
Univ Hosp, Dept Infantile Psychiat, Brest, France.
Univ Hosp, Registry Canc, Brest, France.
Univ Hosp, Dept Pediatry, Brest, France.
NR 0
TC 0
Z9 0
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 0022-202X
J9 J INVEST DERMATOL
JI J. Invest. Dermatol.
PD DEC
PY 2005
VL 125
IS 6
BP A22
EP A22
PG 1
WC Dermatology
SC Dermatology
GA 991OS
UT WOS:000233823900120
ER
PT J
AU Vorbrodt, AW
Dobrogowska, DH
Kozlowski, PB
Rabe, A
Tarnawski, M
Lee, MH
AF Vorbrodt, A. W.
Dobrogowska, D. H.
Kozlowski, P. B.
Rabe, A.
Tarnawski, M.
Lee, M. H.
TI Immunogold study of effects of prenatal exposure to lipopolysaccharide
and/or valproic acid on the rat blood-brain barrier vessels
SO JOURNAL OF NEUROCYTOLOGY
LA English
DT Article
ID GLUCOSE-TRANSPORTER GLUT-1; ELECTRON-MICROSCOPIC IMMUNOGOLD;
SCRAPIE-INFECTED MICE; ENDOGENOUS ALBUMIN; IMMUNOCYTOCHEMICAL
EVALUATION; ENDOTHELIAL-CELLS; MOUSE-BRAIN; AUTISM; DEFICIENCY;
PERMEABILITY
AB The involvement of blood microvessels, representing the anatomic site of the blood-brain barrier (BBB), in brain damage induced by prenatal exposure to lipopolysaccharide (LPS) and/or valproic acid (VPA) was studied in four-week-old rats. The immunogold procedure was applied for localization at the ultrastructural level of endogenous albumin and glucose transporter (GLUT-1) in three brain regions: cerebral cortex, cerebellum and hippocampus. Four groups of rats were used: (1) untreated control, (2) prenatally VPA-treated, (3) prenatally LPS-treated, and (4) prenatally LPS- and VPA-treated. The functional state of the BBB was evaluated as follows: (a) by its tightness, i.e., permeability to blood-borne albumin, and (b) by the expression of GLUT-1 in the endothelial cells (ECs). Using morphometry, the labelling density for GLUT-1 was recorded over luminal and abluminal plasma membranes of the ECs, also providing information on their functional polarity. No extensive increase of vascular permeability and/or any considerable dysfunction of the BBB in experimental groups nos. 2 and 3 were observed, although in solitary vascular profiles, increased endocytosis or even transcytosis of albumin by ECs was noted. In experimental group no. 4, some vascular profiles showed scanty leakage (microleakage), manifested by the presence of immunosignals for albumin in the perivascular area. Although some fluctuations in the expression of GLUT-1 occurred in all experimental groups, especially in group no. 3, a most pronounced and significant diminution of the labelling density, in all three regions of the brain, was observed in group no. 4. This finding suggests the synergistic action of prenatally applied LPS and VPA that affects specific transport functions of glucose in the microvascular endothelium. The diminished or disturbed supply of glucose to selected brain regions can be one of the factors leading to previously observed behavioral disturbances in similarly treated rats.
C1 New York State Off Mental Retardat & Dev Disabil, Inst Basic Res Dev Disabil, Staten Isl, NY 10314 USA.
RP Vorbrodt, AW (reprint author), New York State Off Mental Retardat & Dev Disabil, Inst Basic Res Dev Disabil, 1050 Forest Hill Rd, Staten Isl, NY 10314 USA.
EM dobrogowska@msn.com
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XIA M, 2004, 1979 SOC NEUR
NR 43
TC 4
Z9 4
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0300-4864
J9 J NEUROCYTOL
JI J. Neurocytol.
PD DEC
PY 2005
VL 34
IS 6
BP 435
EP 446
DI 10.1007/s11068-006-8729-x
PG 12
WC Cell Biology; Neurosciences
SC Cell Biology; Neurosciences & Neurology
GA 073FX
UT WOS:000239729500007
PM 16902764
ER
PT J
AU Apple, AL
Billingsley, F
Schwartz, IS
AF Apple, AL
Billingsley, F
Schwartz, IS
TI Effects of video modeling alone and with self-management on
compliment-giving behaviors of children with high-functioning ASD
SO JOURNAL OF POSITIVE BEHAVIOR INTERVENTIONS
LA English
DT Article
ID SOCIAL SKILLS; DEVELOPMENTAL-DISABILITIES; AUTISTIC-CHILDREN;
TEACHING-CHILDREN; TREATMENT PACKAGE; PLAY; RATIONALE; STUDENTS
AB Children with high- functioning autism spectrum disorders (ASD) typically exhibit a lack of social reciprocity skills. They often struggle to maintain conversations, especially with topics of little or no interest to them, and to create meaningful relationships. By giving compliments to others, children with ASD have a means by which to show approval for issues of interest to others. Video modeling has been shown to be effective in teaching social behaviors, particularly when it is followed by additional practice, prompts, and role playing. This study, involving two experiments, focused on teaching compliment-giving responses and initiations through video modeling with embedded, explicit rules for giving compliments in the place of additional procedures following video viewing. A multiple-baseline design across participants revealed that video modeling with explicit rules served to produce and maintain compliments of the "response" type. Video modeling with the addition of contrived reinforcement contingencies served to produce compliment-giving initiations in the presence of a teacher who monitored the children's behavior. The results of Experiment 2 showed that the inclusion of self-management strategies increased the children's independence in the monitoring of their compliment-giving initiations. Experimental results pointed to the use of self-management as a means by which to produce social initiations when video modeling alone fails.
C1 Univ Washington, Seattle, WA 98195 USA.
NW Behav Associates, Kirkland, WA 98034, Australia.
RP Apple, AL (reprint author), Univ Washington, Seattle, WA 98195 USA.
EM alowy@nba-autism.com
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NR 35
TC 57
Z9 57
PU PRO-ED INC
PI AUSTIN
PA 8700 SHOAL CREEK BLVD, AUSTIN, TX 78757-6897 USA
SN 1098-3007
J9 J POSIT BEHAV INTERV
JI J. Posit. Behav. Interv.
PD WIN
PY 2005
VL 7
IS 1
BP 33
EP 46
DI 10.1177/10983007050070010401
PG 14
WC Psychology, Clinical; Education, Special
SC Psychology; Education & Educational Research
GA 883UL
UT WOS:000226041100004
ER
PT J
AU [Anonymous]
AF [Anonymous]
TI The boy who loved windows: Opening the heart and mind of a child
threatened with autism.
SO JOURNAL OF SOCIAL WORK EDUCATION
LA English
DT Book Review
CR STACEY P, 2004, BOY LOVED WNDOWS OPE
NR 1
TC 0
Z9 0
PU COUNC SOC WORK EDUC
PI ALEXANDRIA
PA 1600 DUKE STREET, ALEXANDRIA, VA 22314 USA
SN 1043-7797
J9 J SOC WORK EDUC
JI J. Soc. Work Educ.
PD WIN
PY 2005
VL 41
IS 1
BP 163
EP 163
PG 1
WC Education & Educational Research; Social Work
SC Education & Educational Research; Social Work
GA 962FH
UT WOS:000231715900020
ER
PT J
AU Seeman, C
AF Seeman, C
TI Could it be autism?: A parent's guide to the first signs and next steps.
SO LIBRARY JOURNAL
LA English
DT Book Review
C1 Univ Michigan, Ann Arbor, MI 48109 USA.
RP Seeman, C (reprint author), Univ Michigan, Ann Arbor, MI 48109 USA.
CR Wiseman Nancy D., 2006, COULD IT BE AUTISM P
NR 1
TC 0
Z9 0
PU BOWKER MAGAZINE GROUP CAHNERS MAGAZINE DIVISION
PI NEW YORK
PA 249 W 17TH ST, NEW YORK, NY 10011 USA
SN 0363-0277
J9 LIBR J
JI Libr. J.
PD DEC
PY 2005
VL 130
IS 20
BP 162
EP +
PG 2
WC Information Science & Library Science
SC Information Science & Library Science
GA 992ZX
UT WOS:000233923600321
ER
PT J
AU Devlin, B
Cook, EH
Coon, H
Dawson, G
Grigorenko, EL
McMahon, W
Minshew, N
Pauls, D
Smith, M
Spence, MA
Rodier, PM
Stodgell, C
Schellenberg, GD
AF Devlin, B
Cook, EH
Coon, H
Dawson, G
Grigorenko, EL
McMahon, W
Minshew, N
Pauls, D
Smith, M
Spence, MA
Rodier, PM
Stodgell, C
Schellenberg, GD
CA CPEA Genetics Network
TI Autism and the serotonin transporter: the long and short of it
SO MOLECULAR PSYCHIATRY
LA English
DT Article
DE autism; serotonin transporter; heterogeneity; genetic association;
autistic disorder
ID FAMILY-BASED ASSOCIATION; GENE PROMOTER VARIANTS; LINKAGE
DISEQUILIBRIUM; GENOMEWIDE SCREEN; PERSONALITY-TRAITS; GENOMIC SCREEN;
DISORDER; SLC6A4; REGION; POLYMORPHISM
AB Autism is a neurodevelopmental disorder manifesting early in childhood. Some symptoms of autism are alleviated by treatment with selective serotonin reuptake inhibitors, which are known to interact with the serotonin transporter. Moreover, variation in the gene that encodes the transporter ( SLC6A4), especially the HTTLPR locus, is known to modulate its expression. It is natural, therefore, to evaluate whether this variation plays a role in liability to autism. We investigated the impact of alleles at HTTLPR and three other loci in SLC6A4 by using a large, independent family- based sample ( 390 families, 1528 individuals) from the NIH Collaborative Programs of Excellence in Autism ( CPEA) network. Allele transmissions to individuals diagnosed with autism were biased only for HTTLPR, both for the narrow diagnosis of autism ( P = 0.035) and for the broader diagnosis of autism spectrum ( P = 0.007). The short allele of HTTLPR was significantly overtransmitted. Investigation of haplotype transmissions suggested that, in our data, biased transmission was only due to HTTLPR. With respect to this locus, there are now seven of 12 studies reporting significant transmission bias of HTTLPR alleles, a noteworthy result in itself. However, the studies with significant findings are almost equally divided between overtransmission of short and overtransmission of long alleles. We place our results within this extremely heterogeneous field of studies. Determining the factors influencing the relationship between autism phenotypes and HTTLPR variation, as well as other loci in SLC6A4, could be an important advance in our understanding of this complex disorder.
C1 Vet Affairs Med Ctr, Seattle, WA 98108 USA.
Univ Pittsburgh, Dept Psychiat, Pittsburgh, PA USA.
Univ Illinois, Inst Juvenile Res, Dept Psychiat, Chicago, IL USA.
Univ Utah, Dept Psychiat, Div Child & Adolescent Psychiat, Salt Lake City, UT USA.
Univ Washington, Dept Psychol, Seattle, WA 98195 USA.
Yale Univ, Sch Med, Ctr Child Study, New Haven, CT 06510 USA.
Yale Univ, Sch Med, Dept Psychol, New Haven, CT 06510 USA.
Harvard Univ, Sch Med, Massachusetts Gen Hosp, Unit Psychiat & Neurodev Genet, Charlestown, MA USA.
Univ Calif Irvine, Dept Pediat, Irvine, CA 92717 USA.
Univ Rochester, Med Ctr, Dept OB GYN, Rochester, NY 14642 USA.
Univ Washington, Dept Med, Seattle, WA USA.
Univ Washington, Dept Neurol, Seattle, WA USA.
Univ Washington, Dept Pharmacol, Seattle, WA 98195 USA.
RP Schellenberg, GD (reprint author), Vet Affairs Med Ctr, 182B,1660 S Columbian Rd, Seattle, WA 98108 USA.
EM zachdad@u.washington.edu
RI Stodgell, Christopher/A-1161-2007
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NR 44
TC 108
Z9 115
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1359-4184
J9 MOL PSYCHIATR
JI Mol. Psychiatr.
PD DEC
PY 2005
VL 10
IS 12
BP 1110
EP 1116
DI 10.1038/sj.mp.4001724
PG 7
WC Biochemistry & Molecular Biology; Neurosciences; Psychiatry
SC Biochemistry & Molecular Biology; Neurosciences & Neurology; Psychiatry
GA 986QA
UT WOS:000233463600008
PM 16103890
ER
PT J
AU Tavazoie, SF
Alvarez, VA
Ridenour, DA
Kwiatkowski, DJ
Sabatini, BL
AF Tavazoie, SF
Alvarez, VA
Ridenour, DA
Kwiatkowski, DJ
Sabatini, BL
TI Regulation of neuronal morphology and function by the tumor suppressors
Tsc1 and Tsc2
SO NATURE NEUROSCIENCE
LA English
DT Article
ID TUBEROUS SCLEROSIS COMPLEX; LONG-TERM DEPRESSION; DENDRITIC SPINE
MORPHOGENESIS; LHERMITTE-DUCLOS-DISEASE; CELL-GROWTH; SYNAPTIC
PLASTICITY; SIGNALING PATHWAY; PRODUCT TUBERIN; ACTIN DYNAMICS; KNOCKOUT
MICE
AB Mutations in the TSC1 or TSC2 tumor suppressor genes lead to tuberous sclerosis complex (TSC), a dominant hamartomatous disorder that often presents with mental retardation, epilepsy and autism. The etiology of these neurological symptoms is unclear and the function of the TSC pathway in neurons is unknown. We found that in post-mitotic, hippocampal pyramidal neurons of mice and rats, loss of Tsc1 or Tsc2 triggered enlargement of somas and dendritic spines and altered the properties of glutamatergic synapses. Furthermore, loss of a single copy of the Tsc1 gene was sufficient to perturb dendritic spine structure. Morphological changes required regulation of the actin-depolymerization factor cofilin at a conserved LIM-kinase phosphorylation site, the phosphorylation of which was increased by loss of Tsc2. Thus, the TSC pathway regulates growth and synapse function in neurons, and perturbations of neuronal structure and function are likely to contribute to the pathogenesis of the neurological symptoms of TSC.
C1 Harvard Univ, Sch Med, Dept Neurobiol, Boston, MA 02115 USA.
Harvard Univ, Sch Med, Brigham & Womens Hosp, Dept Med, Boston, MA 02115 USA.
RP Sabatini, BL (reprint author), Harvard Univ, Sch Med, Dept Neurobiol, 220 Longwood Ave, Boston, MA 02115 USA.
EM bsabatini@hms.harvard.edu
RI Alvarez, Veronica /E-9745-2015
OI Alvarez, Veronica /0000-0003-2611-8675
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NR 50
TC 206
Z9 216
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 345 PARK AVENUE SOUTH, NEW YORK, NY 10010-1707 USA
SN 1097-6256
J9 NAT NEUROSCI
JI Nat. Neurosci.
PD DEC
PY 2005
VL 8
IS 12
BP 1727
EP 1734
DI 10.1038/nn1566
PG 8
WC Neurosciences
SC Neurosciences & Neurology
GA 988FC
UT WOS:000233576200022
PM 16286931
ER
PT J
AU Hollander, E
Chaplin, W
Phillips, A
Sumner, J
Soorya, L
Anagnostou, E
Wasserman, S
AF Hollander, E
Chaplin, W
Phillips, A
Sumner, J
Soorya, L
Anagnostou, E
Wasserman, S
TI Oxytocin increases social cognition in autism
SO NEUROPSYCHOPHARMACOLOGY
LA English
DT Meeting Abstract
CT 44th Annual Meeting of the American-College-Neuropsychopharmacology
CY DEC 11-15, 2005
CL Waikoloa, HI
SP Vanderbilt Univ Sch Med Dept Psychiat
C1 CUNY Mt Sinai Sch Med, Dept Psychiat, New York, NY 10029 USA.
NR 0
TC 0
Z9 0
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0893-133X
J9 NEUROPSYCHOPHARMACOL
JI Neuropsychopharmacology
PD DEC
PY 2005
VL 30
SU 1
BP S155
EP S155
PG 1
WC Neurosciences; Pharmacology & Pharmacy; Psychiatry
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA 986IA
UT WOS:000233442100408
ER
PT J
AU Levitt, P
Campbell, DB
Eagleson, KL
Bonnin, A
Persico, AM
Sutcliffe, JS
AF Levitt, P
Campbell, DB
Eagleson, KL
Bonnin, A
Persico, AM
Sutcliffe, JS
TI Clues from basic neurodevelopment for new treatment targets in autism
SO NEUROPSYCHOPHARMACOLOGY
LA English
DT Meeting Abstract
CT 44th Annual Meeting of the American-College-Neuropsychopharmacology
CY DEC 11-15, 2005
CL Waikoloa, HI
SP Vanderbilt Univ Sch Med Dept Psychiat
C1 Vanderbilt Univ, Vanderbilt Kennedy Ctr Res Human Dev, Nashville, TN USA.
NR 0
TC 0
Z9 0
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0893-133X
J9 NEUROPSYCHOPHARMACOL
JI Neuropsychopharmacology
PD DEC
PY 2005
VL 30
SU 1
BP S71
EP S72
PG 2
WC Neurosciences; Pharmacology & Pharmacy; Psychiatry
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA 986IA
UT WOS:000233442100199
ER
PT J
AU McDougle, CJ
Stigler, KA
Posey, DJ
AF McDougle, CJ
Stigler, KA
Posey, DJ
TI Pharmacological treatment of behavioral symptoms in autism
SO NEUROPSYCHOPHARMACOLOGY
LA English
DT Meeting Abstract
CT 44th Annual Meeting of the American-College-Neuropsychopharmacology
CY DEC 11-15, 2005
CL Waikoloa, HI
SP Vanderbilt Univ Sch Med Dept Psychiat
C1 Indiana Univ, Sch Med, Indianapolis, IN USA.
NR 0
TC 1
Z9 1
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0893-133X
J9 NEUROPSYCHOPHARMACOL
JI Neuropsychopharmacology
PD DEC
PY 2005
VL 30
SU 1
BP S72
EP S72
PG 1
WC Neurosciences; Pharmacology & Pharmacy; Psychiatry
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA 986IA
UT WOS:000233442100200
ER
PT J
AU Sutcliffe, JS
Delahanty, RJ
Prasad, HC
Han, Q
Jiang, L
Blakely, RD
AF Sutcliffe, JS
Delahanty, RJ
Prasad, HC
Han, Q
Jiang, L
Blakely, RD
TI Dysfunction of critical regulators of serotonergic signaling confers
autism susceptibility
SO NEUROPSYCHOPHARMACOLOGY
LA English
DT Meeting Abstract
CT 44th Annual Meeting of the American-College-Neuropsychopharmacology
CY DEC 11-15, 2005
CL Waikoloa, HI
SP Vanderbilt Univ Sch Med Dept Psychiat
C1 Vanderbilt Univ, Ctr Mol Neurosci, Nashville, TN USA.
Vanderbilt Univ, Vanderbilt Kennedy Ctr Res Human Dev, Nashville, TN USA.
NR 0
TC 0
Z9 0
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0893-133X
J9 NEUROPSYCHOPHARMACOL
JI Neuropsychopharmacology
PD DEC
PY 2005
VL 30
SU 1
BP S157
EP S157
PG 1
WC Neurosciences; Pharmacology & Pharmacy; Psychiatry
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA 986IA
UT WOS:000233442100415
ER
PT J
AU Wassink, TH
Cody, H
Mosconi, M
Epping, E
Piven, J
AF Wassink, TH
Cody, H
Mosconi, M
Epping, E
Piven, J
TI Cortical and amygdala overgrowth in autism associated with 5-HTTLPR
SO NEUROPSYCHOPHARMACOLOGY
LA English
DT Meeting Abstract
CT 44th Annual Meeting of the American-College-Neuropsychopharmacology
CY DEC 11-15, 2005
CL Waikoloa, HI
SP Vanderbilt Univ Sch Med Dept Psychiat
C1 Carver Coll Med, Iowa City, IA USA.
NR 0
TC 1
Z9 1
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0893-133X
J9 NEUROPSYCHOPHARMACOL
JI Neuropsychopharmacology
PD DEC
PY 2005
VL 30
SU 1
BP S158
EP S158
PG 1
WC Neurosciences; Pharmacology & Pharmacy; Psychiatry
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA 986IA
UT WOS:000233442100416
ER
PT J
AU Young, LJ
AF Young, LJ
TI Neuropeptides and the social brain: The value of comparative studies in
autism research
SO NEUROPSYCHOPHARMACOLOGY
LA English
DT Meeting Abstract
CT 44th Annual Meeting of the American-College-Neuropsychopharmacology
CY DEC 11-15, 2005
CL Waikoloa, HI
SP Vanderbilt Univ Sch Med Dept Psychiat
C1 Emory Univ, Atlanta, GA 30322 USA.
NR 0
TC 0
Z9 0
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0893-133X
J9 NEUROPSYCHOPHARMACOL
JI Neuropsychopharmacology
PD DEC
PY 2005
VL 30
SU 1
BP S71
EP S71
PG 1
WC Neurosciences; Pharmacology & Pharmacy; Psychiatry
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA 986IA
UT WOS:000233442100197
ER
PT J
AU Mandell, DS
Novak, MM
Zubritsky, CD
AF Mandell, DS
Novak, MM
Zubritsky, CD
TI Factors associated with age of diagnosis among children with autism
spectrum disorders
SO PEDIATRICS
LA English
DT Article
DE autism; developmental delay; medical home; referral/consultation
ID PERVASIVE DEVELOPMENTAL DISORDERS; HEALTH-CARE NEEDS; LOW-INCOME
CHILDREN; MEDICAL HOME; EARLY IDENTIFICATION; GENERAL-PRACTICE;
NATIONAL-SURVEY; YOUNG-CHILDREN; FOLLOW-UP; ACCESS
AB Objective. Early diagnosis of children with autism spectrum disorders ( ASD) is critical but often delayed until school age. Few studies have identified factors that may delay diagnosis. This study attempted to identify these factors among a community sample of children with ASD.
Methods. Survey data were collected in Pennsylvania from 969 caregivers of children who had ASD and were younger than 21 years regarding their service experiences. Linear regression was used to identify clinical and demographic characteristics associated with age of diagnosis.
Results. The average age of diagnosis was 3.1 years for children with autistic disorder, 3.9 years for pervasive developmental disorder not otherwise specified, and 7.2 years for Asperger's disorder. The average age of diagnosis increased 0.2 years for each year of age. Rural children received a diagnosis 0.4 years later than urban children. Near-poor children received a diagnosis 0.9 years later than those with incomes > 100% above the poverty level. Children with severe language deficits received a diagnosis an average of 1.2 years earlier than other children. Hand flapping, toe walking, and sustained odd play were associated with a decrease in the age of diagnosis, whereas oversensitivity to pain and hearing impairment were associated with an increase. Children who had 4 or more primary care physicians before diagnosis received a diagnosis 0.5 years later than other children, whereas those whose pediatricians referred them to a specialist received a diagnosis 0.3 years sooner.
Conclusion. These findings suggest improvements over time in decreasing the age at which children with ASD, especially higher functioning children, receive a diagnosis. They also suggest a lack of resources in rural areas and for near-poor families and the importance of continuous pediatric care and specialty referrals. That only certain ASD-related behaviors, some of which are not required to satisfy diagnostic criteria, decreased the age of diagnosis suggests the importance of continued physician education.
C1 Univ Penn, Ctr Mental Hlth Policy & Serv Res, Sch Med, Dept Psychiat, Philadelphia, PA 19104 USA.
RP Mandell, DS (reprint author), Univ Penn, Ctr Mental Hlth Policy & Serv Res, Sch Med, Dept Psychiat, 3535 Market St,3rd Fl, Philadelphia, PA 19104 USA.
EM mandelld@mail.med.upenn.edu
RI Mandelld, David/A-1044-2007; Mandell, David/H-2730-2012
OI Mandell, David/0000-0001-8240-820X
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NR 65
TC 176
Z9 182
PU AMER ACAD PEDIATRICS
PI ELK GROVE VILLAGE
PA 141 NORTH-WEST POINT BLVD,, ELK GROVE VILLAGE, IL 60007-1098 USA
SN 0031-4005
J9 PEDIATRICS
JI Pediatrics
PD DEC
PY 2005
VL 116
IS 6
BP 1480
EP 1486
DI 10.1542/peds.2005-0185
PG 7
WC Pediatrics
SC Pediatrics
GA 989JH
UT WOS:000233668200029
PM 16322174
ER
PT J
AU Veltman, MWM
Craig, EE
Bolton, PF
AF Veltman, MWM
Craig, EE
Bolton, PF
TI Autism spectrum disorders in Prader-Willi and Angelman syndromes: a
systematic review
SO PSYCHIATRIC GENETICS
LA English
DT Review
DE Prader-Willi syndrome; Angelman syndrome; autistic spectrum disorders;
autism; systematic review
ID PATERNAL UNIPARENTAL DISOMY; HAPPY PUPPET SYNDROME; INTERSTITIAL
DUPLICATIONS; MALADAPTIVE BEHAVIOR; MENTAL-RETARDATION; PROXIMAL 15Q;
SCREENING QUESTIONNAIRE; EMOTIONAL DISTURBANCE; DIAGNOSTIC-CRITERIA;
PSYCHOTIC SYMPTOMS
AB Autism spectrum disorders (ASDs) have been linked with maternally derived duplications/triplications of chromosome 15q11-13 and therefore might occur more frequently in people with Prader-Willi syndrome (PWS) when due to uniparental disomy (UPD), than in other forms of chromosomal abnormality involving this region [i.e. deletion (DEL) forms of PWS and DEL+ UPD forms of Angelman's syndrome -(AS)]. Twelve studies regarding ASD in PWS and AS were reviewed. It was noteworthy that among the genetically confirmed UPD and DEL cases of PWS and AS, the rate of ASD was 25.3% (38/150; range 0-36.5%) in PWS and 1.9% in AS (2/104; range 0-100%) (Fisher's exact P < 0.0001). Among the subset of cases with confirmed UPD or DEL, the rate of ASD in the UPD cases of PWS was significantly higher (20/53) than in the remaining combined samples (i.e. DEL PWS+UPD AS+DEL AS cases; 20/201) (Fisher's exact P < 0.0001). ASD in UPD PWS cases (20/53) compared with DEL PWS cases (18/97) was also statistically significant (Fisher's exact P=0.0176). Thus, the limited available evidence supported the prediction that overexpression of maternally imprinted genes in 15q11-13 confers a risk for ASD. Further research will be required to confirm these findings. Psychiatr Genet 15:243-254 (c) 2005 Lippincott Williams & Wilkins.
C1 Univ Cambridge, Dev Psychiat Sect, Dept Psychiat, Cambridge CB2 2AH, England.
Univ London, Inst Psychiat, MRC, Social Genet & Dev Psychiat Res Ctr, London, England.
RP Veltman, MWM (reprint author), Univ Cambridge, Dev Psychiat Sect, Dept Psychiat, Douglas House,18B Trumpington Rd, Cambridge CB2 2AH, England.
EM mwmv2@cam.ac.uk
RI Bolton, Patrick/E-8501-2010
OI Bolton, Patrick/0000-0002-5270-6262
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TC 89
Z9 89
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3261 USA
SN 0955-8829
J9 PSYCHIAT GENET
JI Psychiatr. Genet.
PD DEC
PY 2005
VL 15
IS 4
BP 243
EP 254
DI 10.1097/00041444-200512000-00006
PG 12
WC Genetics & Heredity; Neurosciences
SC Genetics & Heredity; Neurosciences & Neurology
GA 993UB
UT WOS:000233979500005
PM 16314754
ER
PT J
AU Takeda, T
Koyama, T
Kanai, C
Kurita, H
AF Takeda, T
Koyama, T
Kanai, C
Kurita, H
TI Clinical variables at age 2 predictive of mental retardation at age 5 in
children with pervasive developmental disorder
SO PSYCHIATRY AND CLINICAL NEUROSCIENCES
LA English
DT Article
DE autistic disorder; mental retardation; pervasive developmental disorder;
prognosis
ID AUTISM RATING-SCALE; CHILDHOOD AUTISM; FOLLOW-UP; PRESCHOOL-CHILDREN;
TOKYO VERSION; INTERVENTION; LANGUAGE; CARS
AB This study attempted to find clinical variables evaluated at age 2 that would predict mental retardation (MR, IQ/cognition-adaptation developmental quotient [C-A DQ] < 70) at age 5 in 57 children with pervasive developmental disorder (PDD). About two-thirds of subjects had MR at both initial and outcome evaluations. The C-A DQ at initial evaluation was significantly lower in mentally retarded PDD (MRPDD) than in high-functioning (IQ >= 70) PDD (HFPDD). MRPDD changed less than HFPDD in IQ/C-A DQ between ages 2 and 5. The C-A DQ at age 2 was a potent predictor for MR at age 5 and the total score and three item scores of Childhood Autism Rating Scale-Tokyo Version evaluated at age 2 were also useful in predicting MR at age 5.
C1 Univ Tokyo, Grad Sch Med, Dept Neuropsychiat, Bunkyo Ku, Tokyo 1130033, Japan.
Univ Tokyo, Grad Sch Med, Dept Mental Hlth, Tokyo, Japan.
Natl Ctr Neurol & Psychiat, NIMH, Dept Mental Hlth Adm, Kodaira, Tokyo, Japan.
RP Takeda, T (reprint author), Univ Tokyo, Grad Sch Med, Dept Neuropsychiat, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1130033, Japan.
EM t-tak@umin.ac.jp
CR American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th
BallabanGil K, 1996, PEDIATR NEUROL, V15, P217, DOI 10.1016/S0887-8994(96)00219-6
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*TAN I ED, 1987, TAN BIN INT TEST
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WHO, 1993, ICD 10 CLASS MENT BE
NR 28
TC 4
Z9 4
PU BLACKWELL PUBLISHING
PI OXFORD
PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND
SN 1323-1316
J9 PSYCHIAT CLIN NEUROS
JI Psychiatry Clin. Neurosci.
PD DEC
PY 2005
VL 59
IS 6
BP 717
EP 722
DI 10.1111/j.1440-1819.2005.01442.x
PG 6
WC Clinical Neurology; Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA 989ED
UT WOS:000233654800015
PM 16401249
ER
PT J
AU Pilling, G
AF Pilling, G
TI Understanding autism spectrum disorders - Frequently asked questions
SO PSYCHOLOGIST
LA English
DT Book Review
CR YAPKO D, 2005, UNDERSTANDING AUTISM
NR 1
TC 0
Z9 0
PU BRITISH PSYCHOLOGICAL SOC
PI LEICESTER
PA ST ANDREWS HOUSE, 48 PRINCESS RD EAST, LEICESTER LE1 7DR, LEICS, ENGLAND
SN 0952-8229
J9 PSYCHOLOGIST
JI Psychologist
PD DEC
PY 2005
VL 18
IS 12
BP 755
EP 755
PG 1
WC Psychology, Multidisciplinary
SC Psychology
GA 990OF
UT WOS:000233752400045
ER
PT J
AU Avdi, E
AF Avdi, E
TI Negotiating a pathological identity in the clinical dialogue: Discourse
analysis of a family therapy
SO PSYCHOLOGY AND PSYCHOTHERAPY-THEORY RESEARCH AND PRACTICE
LA English
DT Article
ID QUALITATIVE-ANALYSIS; PSYCHOTHERAPY; POWER; PSYCHOLOGY; PATHWAYS;
POLITICS; CLIENTS; VOICES; SELF
AB Within the framework of social construction ism, psychotherapy has been re-conceptualized as a semiotic process, which consists of the creative generation of new meanings in the context of collaborative discourse. In recent years, research approaches that draw from social constructionism, such as discourse analysis, have been fruitfully employed in the study of psychotherapy processes, whilst being in line with the contemporary emphasis on language, narrative, and meaning making. This paper aims to further the exploration of the usefulness of discourse analysis in the study of psychotherapy processes, and in particular, in situations where the medical discourse is powerfully implicated in the construction of a person's identity. It is based on the analysis of a family therapy with a family whose child has a diagnosis of autism. The analysis focuses on two features of the family's talk, namely shifts in the flexibility of employment of a diverse range of discourses and subject positions, and shifts in the ways agency is constructed and discursively negotiated in the clinical conversations. It is suggested that these shifts can be used as indications of change in the family's network of meanings. The analysis suggests that an important aspect in clinical work with families with a member with a psychiatric diagnosis lies in decentring, or deconstructing, the dominant, pathology-maintaining accounts, and allowing for a wider range of less problematic narratives and subject positions to emerge.
C1 Aristotle Univ Thessaloniki, Dept Psychol, Thessaloniki 54124, Greece.
RP Avdi, E (reprint author), Aristotle Univ Thessaloniki, Dept Psychol, Thessaloniki 54124, Greece.
EM avdie@psy.auth.gr
CR ANDERSON H, 1988, FAM PROCESS, V27, P371, DOI 10.1111/j.1545-5300.1988.00371.x
Avdi E, 2000, J Health Psychol, V5, P241, DOI 10.1177/135910530000500214
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AVDI E, 1998, THESIS U BIRMINGHTAM
Burck C, 1998, J FAM THER, V20, P253, DOI 10.1111/1467-6427.00086
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Fee D., 2000, PATHOLOGY POSTMODERN
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NR 59
TC 8
Z9 9
PU BRITISH PSYCHOLOGICAL SOC
PI LEICESTER
PA ST ANDREWS HOUSE, 48 PRINCESS RD EAST, LEICESTER LE1 7DR, LEICS, ENGLAND
SN 1476-0835
J9 PSYCHOL PSYCHOTHER-T
JI Psychol. Psychother.-Theory Res. Pract.
PD DEC
PY 2005
VL 78
BP 493
EP 511
DI 10.1348/147608305X52586
PN 4
PG 19
WC Psychology, Clinical; Psychiatry; Psychology
SC Psychology; Psychiatry
GA 989NY
UT WOS:000233682000006
PM 16354441
ER
PT J
AU Moynahan, L
Stromgren, B
AF Moynahan, L
Stromgren, B
TI Preliminary results of Aggression Replacement Training for Norwegian
youth with aggressive behaviour and with a different diagnosis
SO PSYCHOLOGY CRIME & LAW
LA English
DT Article; Proceedings Paper
CT 3rd International ICART Conference
CY 2004
CL Amsterdam, NETHERLANDS
SP ICART
DE ART; social skills; problem behaviours; children; youth; different
diagnosis
ID AUTISM
AB We present a short summary of the efforts to disseminate Aggression Replacement Training (ART) in Norway following an initial seminar held by Arnold Goldstein in 2000. Data from a pilot study conducted into the effectiveness of ART with children and youth with aggressive behaviour and with a different diagnosis are presented. The data indicate that ART can be an appropriate and effective intervention.
C1 Univ Ulster, Coleraine BT52 1SA, Londonderry, North Ireland.
RP Stromgren, B (reprint author), Glenne Autismctr, Fogdeveien 55, N-3184 Borre, Norway.
EM Borge.Stromgren@siv.no
CR [Anonymous], 1992, INT STAT CLASS DIS R
AOS S, 1996, TRENDS RISK BEHAV YO
Binder C, 1993, EDUC TECHNOL, P8
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Forgatch M. S., 1998, CASE STUDIES COUPLE, P85
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Goldstein A. P., 1998, AGGRESSION REPLACEME
Goldstein A.P., 1995, EQUIP PROGRAM TEACHI
Goldstein A.P, 1988, PREPARE CURRICULUM T
Gresham F. M., 1990, SOCIAL SKILLS RATING
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*ICART, 2005, MIN STAND ICART REC
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NR 22
TC 1
Z9 1
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND
SN 1068-316X
J9 PSYCHOL CRIME LAW
JI Psychol. Crime Law
PD DEC
PY 2005
VL 11
IS 4
BP 411
EP 419
DI 10.1080/10683160500256784
PG 9
WC Criminology & Penology; Law; Psychology, Multidisciplinary
SC Criminology & Penology; Government & Law; Psychology
GA 981XN
UT WOS:000233121400009
ER
PT J
AU Ramsay, JR
Brodkin, ES
Cohen, MR
Listerud, J
Rostain, AL
Ekman, E
AF Ramsay, JR
Brodkin, ES
Cohen, MR
Listerud, J
Rostain, AL
Ekman, E
TI "Better strangers": Using the relationship in psychotherapy for adult
patients with Asperger Syndrome
SO PSYCHOTHERAPY
LA English
DT Article
DE Asperger Syndrome; social skills; therapeutic relationship;
pscychotherapy; cognitive behavior therapy; adults
ID RECEPTIVE LANGUAGE DISORDER; HIGH-FUNCTIONING AUTISM; SPECTRUM
DISORDERS; EXTERNAL VALIDITY; FOLLOW-UP; DIAGNOSIS; OUTCOMES; LIFE
AB Requests for the assessment and treatment of Asperger Syndrome (AS) are on the rise. AS is a pervasive developmental disorder characterized by significantly impaired social competence but intact intellectual functioning. Adult AS patients often present for psychotherapy with anxiety, depression, and problems navigating their social worlds. The challenge facing psychotherapists is to establish workable therapeutic relationships with patients who have fundamental problems understanding and engaging in relationships in their daily lives. The aim of this article is to present strategies for adapting psychotherapy, particularly the therapeutic relationship, for the treatment of adult AS. The authors briefly review the phenomenology of AS and discuss strategies for using the therapeutic relationship to address the social functioning problems of this disorder.
C1 Univ Penn, Sch Med, Dept Psychiat, Philadelphia, PA 19104 USA.
Kognit Beteendeterapi Teamet VastSverige, Gothenburg, Sweden.
RP Ramsay, JR (reprint author), Univ Penn, Sch Med, Dept Psychiat, 3535 Market St 2027, Philadelphia, PA 19104 USA.
EM ramsay@mail.med.upenn.edu
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
American Psychiatric Association, 1994, DIANG STAT MAN MENT
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Klin A., 2000, ASPERGER SYNDROME, P309
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NR 33
TC 2
Z9 2
PU AMER PSYCHOLOGICAL ASSOC, DIV PSYCHOTHERAPY
PI CORAL GABLES
PA 1390 SOUTH DIXIE HIGHWAY, STE 2222, CORAL GABLES, FL 33146-2946 USA
SN 0033-3204
J9 PSYCHOTHERAPY
JI Psychotherapy
PD WIN
PY 2005
VL 42
IS 4
BP 483
EP 493
DI 10.1037/0033-3204.42.4.483
PG 11
WC Psychology, Clinical
SC Psychology
GA 041BC
UT WOS:000237426900007
ER
PT J
AU Baker-Ericzen, MJ
Brookman-Frazee, L
Stahmer, A
AF Baker-Ericzen, MJ
Brookman-Frazee, L
Stahmer, A
TI Stress levels and adaptability in parents of toddlers with and without
autism spectrum disorders
SO RESEARCH AND PRACTICE FOR PERSONS WITH SEVERE DISABILITIES
LA English
DT Article
DE toddlers; inclusion; community program; parental stress; autism
ID YOUNG-CHILDREN; BEHAVIOR PROBLEMS; FAMILY STRESS; SPECIAL NEEDS;
DISABILITIES; MOTHERS; FATHERS; SUPPORT; INTERVENTION; PROFILES
AB The toddler years can be a particularly stressful time for all parents, however, parents of children with disabilities may experience additional sources of stress. Recent literature on early education for children with disabilities promotes inclusion with typical peers with increases in the availability of inclusive programs. However, little is known about early intervention inclusion programs and parental factors such as stress and adaptability. The current study expands the research for children with disabilities by investigating the associations of having a young child with an Autism Spectrum Disorder (ASD) on multiple dimensions of parental stress for mothers and fathers and how participation in an inclusive toddler program may be related to these stress levels. Results for this community sample are consistent with previous research indicating that that both mothers and fathers of children with ASD report significantly elevated levels of both child and parent related stress in comparison with parents of typically developing toddlers. Following their child's participation in the inclusion program, mothers of children with ASD report significant reductions in child-related stress but no reductions in the parent-related stress domain. No changes were seen with either child or parent domain for fathers. Lastly, a child's level of social skills was a significant predictor of child-related maternal stress for children with autism. This pattern was not seen in fathers of these children. Implications for early intervention program modifications, such as increasing family support and incorporating adjunctive parent interventions for parents with elevated levels of stress are discussed.
C1 Childrens Hosp, Child & Adolescent Serv Res Ctr, San Diego, CA USA.
Univ Calif San Diego, La Jolla, CA 92093 USA.
RP Baker-Ericzen, MJ (reprint author), Child & Adolescent Serv Res Ctr, 3020 Childrens Way MC5033, San Diego, CA 92123 USA.
CR Abidin R. R, 1995, MANUAL PARENTING STR
American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th
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NR 56
TC 70
Z9 72
PU TASH
PI BALTIMORE
PA 29 W SUSQUEHANNA AVE, STE 210, BALTIMORE, MD 21204-5201 USA
SN 0274-9483
J9 RES PRACT PERS SEV D
JI Res. Pract. Pers. Sev. Disabil.
PD WIN
PY 2005
VL 30
IS 4
BP 194
EP 204
DI 10.2511/rpsd.30.4.194
PG 11
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA 055RP
UT WOS:000238468400002
ER
PT J
AU Marteleto, MRF
Pedromonico, MRM
AF Marteleto, MRF
Pedromonico, MRM
TI Validity of Autism Behavior Checklist (ABC): preliminary study
SO REVISTA BRASILEIRA DE PSIQUIATRIA
LA English
DT Article
DE autistic disorder; diagnostic and statistical manual of mental
disorders; diagnosis; differential; validation studies [publication
type]; questionnaires
ID PERVASIVE DEVELOPMENTAL DISORDERS; SPECTRUM DISORDERS; MENTAL
DISABILITY; CHILDREN; INDIVIDUALS; INSTRUMENTS
AB Objective: To examine the concurrent and criterion validity of the Autism Behavior Checklist (ABC). Methods: Three groups, comprising 38 mothers of children previously diagnosed with autism (DSM IV-TR, 2002), 43 mothers of children with language disorders other than autism, and 52 mothers of children who had no linguistic or behavioral complaints, were interviewed. In order to minimize the effect of maternal level of education, the questionnaire was completed by the researcher To determine the concurrent validation, ANOVA and discriminant analysis were used. The ROC curve was used to establish the cutoff score of the sample and to examine the criterion validity. Results: The mean total score was significantly higher in the group of mothers of autistic children than in the other groups. The ABC correctly identified 81.6% of the autistic children. The ROC curve cutoff score was 49, and the sensitivity was 92.1%, higher than the 57.89% found when a cutoff score of 68 was used. The specificity was 92.6%, similar to the 94.73% obtained with a cutoff score of 68. Conclusions: The ABC shows promise as an instrument for identifying children with autistic disorders, both in clinical and educational contexts, especially when a cutoff score of 49 is used.
C1 Univ Fed Sao Paulo, Dept Speech Therapy, Sao Paulo, Brazil.
RP Marteleto, MRF (reprint author), Dept Fonoaudiol, Disciplina Disturbios Comunicacao Humana, Rua Botucatu 802,Vila Clementino, BR-04023900 Sao Paulo, Brazil.
EM marcia.marteleto@terra.com.br
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NR 24
TC 9
Z9 18
PU ASSOCIACAO BRASILEIRA DE PSIQUIATRIA
PI SAO PAULO
PA SUBSCRIPTION DEPARTMENT, RUA PEDRO DE TOLEDO, 967 - CASA 01, SAO PAULO,
SP, BRAZIL
SN 1516-4446
J9 REV BRAS PSIQUIATR
JI Rev. Bras. Psiquiatr.
PD DEC
PY 2005
VL 27
IS 4
BP 295
EP 301
DI 10.1590/S1516-44462005000400008
PG 7
WC Psychiatry
SC Psychiatry
GA 990FF
UT WOS:000233727900008
PM 16358111
ER
PT J
AU Hume, K
Bellini, S
Pratt, C
AF Hume, K
Bellini, S
Pratt, C
TI The usage and perceived outcomes of early intervention and early
childhood programs for young children with autism spectrum disorder
SO TOPICS IN EARLY CHILDHOOD SPECIAL EDUCATION
LA English
DT Article
ID APPLIED BEHAVIOR ANALYSIS; SOCIAL VALIDITY; PERCEPTIONS; CLASSROOMS;
EDUCATION
AB This study investigated families of children with autism spectrum disorders using early intervention and early childhood services, as well as the perceived efficacy T and developmental outcomes related to the services and service delivery methods. Results indicated that a variety of recommended practices are not being used by families and interventionists and that intensity of engagement is less than suggested. Parents indicated that parent training was the most effective service in contributing to their child's growth. Significant, yet small, correlations were found between several intervention services/service delivery models and developmental outcomes across areas, including social, emotional, and cognitive development. The importance of assessing social validity related to outcomes is addressed, as are potential implications for service providers.
C1 Indiana Univ, Bloomington, IN 47405 USA.
RP Hume, K (reprint author), Indiana Resource Ctr Autism, 2853 E 10th St, Bloomington, IN 47408 USA.
EM kahume@indiana.edu
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NR 41
TC 29
Z9 29
PU PRO-ED INC
PI AUSTIN
PA 8700 SHOAL CREEK BLVD, AUSTIN, TX 78757-6897 USA
SN 0271-1214
J9 TOP EARLY CHILD SPEC
JI Top. Early Child. Spec. Educ.
PD WIN
PY 2005
VL 25
IS 4
BP 195
EP 207
DI 10.1177/02711214050250040101
PG 13
WC Education, Special
SC Education & Educational Research
GA 016UZ
UT WOS:000235647400001
ER
PT J
AU Reiss, JE
Hoffman, JE
Landau, B
AF Reiss, JE
Hoffman, JE
Landau, B
TI Motion processing specialization in Williams syndrome
SO VISION RESEARCH
LA English
DT Article
DE Williams syndrome; motion coherence; biological motion;
form-from-motion; dorsal/ventral visual processing
ID VISUAL AREA MT; FORM-FROM-MOTION; BIOLOGICAL MOTION; DORSAL-STREAM;
MACAQUE MONKEY; PERCEPTION; CHILDREN; AUTISM; COHERENCE; DEFICITS
AB Williams syndrome (WS) is a rare genetic disorder characterized by severe spatial deficits and relatively spared language. Although initial research Suggested that WS entails a generalized motion processing deficit, later work demonstrated intact biological motion perception in people with WS, reflecting a sparing of a specific motion perception system. The present study examined whether this sparing is unique to biological motion, or extends to other motion tasks as well, WS children and adults and normal controls were tested to examine developmental changes across it variety of motion tasks. Results indicated that WS individuals performed at normal levels for motion coherence and biological motion tasks bill had elevated thresholds for the 2-D form-from-motion task, a profile that extended into adulthood. These findings provide evidence that a genetic impairment can lead to a selective motion processing deficit and argue against characterizing WS as including a general motion processing impairment. The nature of the motion deficit is considered, including the implications for WS dorsal/ventral processing. (c) 2005 Elsevier Ltd. All rights reserved.
C1 Univ Delaware, Dept Psychol, Newark, DE 19716 USA.
Johns Hopkins Univ, Dept Cognit Sci, Baltimore, MD 21218 USA.
RP Reiss, JE (reprint author), Univ Delaware, Dept Psychol, Newark, DE 19716 USA.
EM jreiss@udel.edu
RI Hoffman, James/A-3079-2008
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NR 66
TC 38
Z9 39
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0042-6989
J9 VISION RES
JI Vision Res.
PD DEC
PY 2005
VL 45
IS 27
BP 3379
EP 3390
DI 10.1016/j.visres.2005.05.011
PG 12
WC Neurosciences; Ophthalmology
SC Neurosciences & Neurology; Ophthalmology
GA 989AJ
UT WOS:000233645000005
PM 16005929
ER
PT J
AU Hefter, RL
Manoach, DS
Barton, JJS
AF Hefter, RL
Manoach, DS
Barton, JJS
TI Perception of facial expression and facial identity in subjects with
social developmental disorders
SO NEUROLOGY
LA English
DT Article
ID EMOTIONAL PROCESSING DISORDER; AUTISM SPECTRUM DISORDER;
HIGH-FUNCTIONING AUTISM; ASPERGER-SYNDROME; FACE RECOGNITION;
LEARNING-DISABILITY; REVISED VERSION; YOUNG-CHILDREN; NORMAL ADULTS;
INDIVIDUALS
AB Background: It has been hypothesized that the social dysfunction in social developmental disorders (SDDs), such as autism, Asperger disorder, and the socioemotional processing disorder, impairs the acquisition of normal face-processing skills. The authors investigated whether this purported perceptual deficit was generalized to both facial expression and facial identity or whether these different types of facial perception were dissociated in SDDs. Methods: They studied 26 adults with a variety of SDD diagnoses, assessing their ability to discriminate famous from anonymous faces, their perception of emotional expression from facial and nonfacial cues, and the relationship between these abilities. They also compared the performance of two defined subgroups of subjects with SDDs on expression analysis: one with normal and one with impaired recognition of facial identity. Results: While perception of facial expression was related to the perception of nonfacial expression, the perception of facial identity was not related to either facial or nonfacial expression. Likewise, subjects with SDDs with impaired facial identity processing perceived facial expression as well as those with normal facial identity processing. Conclusion: The processing of facial identity and that of facial expression are dissociable in social developmental disorders. Deficits in perceiving facial expression may be related to emotional processing more than face processing. Dissociations between the perception of facial identity and facial emotion are consistent with current cognitive models of face processing. The results argue against hypotheses that the social dysfunction in social developmental disorder causes a generalized failure to acquire face-processing skills.
C1 Beth Israel Deaconess Med Ctr, Dept Neurol, Boston, MA 02215 USA.
Beth Israel Deaconess Med Ctr, Dept Ophthalmol, Boston, MA 02215 USA.
Harvard Univ, Sch Med, Boston, MA 02115 USA.
Massachusetts Gen Hosp, Dept Psychiat, Boston, MA 02114 USA.
Harvard Univ, Sch Med, Athinoula A Martinos Ctr Biomed Imaging, Boston, MA 02115 USA.
Univ British Columbia, Dept Neurol, Vancouver, BC V5Z 1M9, Canada.
Univ British Columbia, Dept Ophthalmol & Visual Sci, Vancouver, BC V5Z 1M9, Canada.
RP Barton, JJS (reprint author), VGH Eye Care Ctr, Neuroophthalmol Sect D, 2550 Willow St, Vancouver, BC V5Z 3N9, Canada.
EM jasonbarton@shaw.ca
RI Barton, Jason/A-6362-2012
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NR 49
TC 26
Z9 27
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3261 USA
SN 0028-3878
J9 NEUROLOGY
JI Neurology
PD NOV 22
PY 2005
VL 65
IS 10
BP 1620
EP 1625
DI 10.1212/01.wnl.0000184498.16959.c0
PG 6
WC Clinical Neurology
SC Neurosciences & Neurology
GA 986CY
UT WOS:000233428100020
PM 16301491
ER
PT J
AU Malmgren, H
Malm, G
Sahlen, S
Karlsson, M
Blennow, E
AF Malmgren, H
Malm, G
Sahlen, S
Karlsson, M
Blennow, E
TI Molecular cytogenetic characterization of an insertional translocation,
ins(6;7)(p25;q33q34): Deletion/duplication of 7q33-34 and clinical
correlations
SO AMERICAN JOURNAL OF MEDICAL GENETICS PART A
LA English
DT Article
DE insertion; duplication; deletion; chromosome 7
ID CHROMOSOME REARRANGEMENTS; INTERSTITIAL DELETION; MENTAL-RETARDATION;
AUTISM; GENOME
AB A balanced insertional translocation between chromosomes 6 and 7, ins(6;7)(p25;q33q34) has been extensively investigated. The insertional translocation was found in several members of a three-generation family, where some were healthy balanced carriers while others had clinical symptoms due to deletion or duplication of 7q33-34. The deleted/duplicated segment could only be detected using high resolution banding and fluorescent in situ hybridization. A number of BAC/PAC clones located on chromosome 6 and 7 were used to characterize the breakpoint regions in detail and to determine the size of the deletion, which was 7.6 Mb, containing up to 68 genes. However, the insert on chromosome 6 was only 7.4 Mb, due to a deletion of 227 kb at the distal breakpoint on 7q. This small deletion was also found in the "balanced" carriers, and although the chromosome segment contains at least eight genes, none of the carriers seem to be affected by haploinsufficiency, since the phenotype is apparently normal. This is the first detailed characterization and phenotype correlation of such a deletion/duplication of distal 7q. (c) 2005 Wiley-Liss, Inc.
C1 Karolinska Univ Hosp, Dept Clin Genet, Dept Pediat, S-17176 Stockholm, Sweden.
Karolinska Inst, Clin Genet Unit, Dept Mol Med, Stockholm, Sweden.
RP Blennow, E (reprint author), Karolinska Univ Hosp, Dept Clin Genet, Dept Pediat, S-17176 Stockholm, Sweden.
EM Elisabeth.Blennow@cmm.ki.se
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NR 16
TC 2
Z9 2
PU WILEY-LISS
PI HOBOKEN
PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 1552-4825
J9 AM J MED GENET A
JI Am. J. Med. Genet. A
PD NOV 15
PY 2005
VL 139A
IS 1
BP 25
EP 31
DI 10.1002/ajmg.a.30983
PG 7
WC Genetics & Heredity
SC Genetics & Heredity
GA 981AL
UT WOS:000233059300006
PM 16222668
ER
PT J
AU Nowinski, CV
Minshew, NJ
Luna, B
Takarae, Y
Sweeney, JA
AF Nowinski, CV
Minshew, NJ
Luna, B
Takarae, Y
Sweeney, JA
TI Oculomotor studies of cerebellar function in autism
SO PSYCHIATRY RESEARCH
LA English
DT Article
DE developmental disabilities; cerebellum; eye movements; motor control;
saccades
ID SQUARE-WAVE JERKS; EYE-MOVEMENTS; SEROTONIN TRANSPORTER; NEOCORTICAL
SYSTEMS; ABNORMALITIES; DISORDER; FIXATION; DEFICITS; ATAXIA;
UNDERDEVELOPMENT
AB Histopathological, neuroimaging and genetic findings indicate cerebellar abnormalities in autism, but the extent of neurophysiological dysfunction associated with those findings has not been systematically examined. Suppression of intrusive saccades (square wave jerks) and the ability to sustain eccentric gaze, two phenomena requiring intact cerebellar function, were examined in 52 high-functioning individuals with autism and 52 age- and IQ-matched healthy subjects during visual fixation of static central and peripheral targets. Rates of intrusive saccades were not increased in autism during visual fixation, and foveopetal ocular drift was also not increased when subjects held an eccentric gaze. The absence of gross disturbances of visual fixation associated with cerebellar disease in individuals with autism, such as increased square wave jerk rates and foveopetal drift when holding eccentric gaze, indicates that the functional integrity of cerebellar-brainstem networks devoted to oculomotor control is preserved in autism despite reported anatomic variations. However, increased amplitude of intrusive saccades and reduced latency of target refixation after intrusive saccades were observed in individuals with autism, especially when subjects maintained lixation of remembered target locations without sensory guidance. The atypical metrics of intrusive saccades that were observed may be attributable to faulty functional connectivity in cortico-cerebellar networks. (c) 2005 Elsevier Ireland Ltd. All rights reserved.
C1 Univ Illinois, Dept Psychiat, Ctr Cognit Med, Coll Med, Chicago, IL 60612 USA.
Univ Illinois, Coll Med, Dept Neurol, Chicago, IL 60612 USA.
Univ Illinois, Coll Med, Dept Psychol, Chicago, IL 60612 USA.
Univ Pittsburgh, Sch Med, Dept Psychiat, Pittsburgh, PA USA.
Univ Pittsburgh, Sch Med, Dept Neurol, Pittsburgh, PA 15261 USA.
RP Sweeney, JA (reprint author), Univ Illinois, Dept Psychiat, Ctr Cognit Med, Coll Med, MC 913,912 S Wood St,Suite 235, Chicago, IL 60612 USA.
EM jsweeney@psych.uic.edu
RI Luna, Beatriz/F-1201-2010
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NR 51
TC 23
Z9 23
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
IRELAND
SN 0165-1781
J9 PSYCHIAT RES
JI Psychiatry Res.
PD NOV 15
PY 2005
VL 137
IS 1-2
BP 11
EP 19
DI 10.1016/j.psychres.2005.07.005
PG 9
WC Psychiatry
SC Psychiatry
GA 987RX
UT WOS:000233536100002
PM 16214219
ER
PT J
AU Sherr, EH
Owen, R
Albertson, DG
Pinkel, D
Cotter, PD
Slavotinek, AM
Hetts, SW
Jeremy, RJ
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Schilmoeller, K
Wakahiro, M
Barkovich, AJ
AF Sherr, EH
Owen, R
Albertson, DG
Pinkel, D
Cotter, PD
Slavotinek, AM
Hetts, SW
Jeremy, RJ
Schilmoeller, G
Schilmoeller, K
Wakahiro, M
Barkovich, AJ
TI Genomic microarray analysis identifies candidate loci in patients with
corpus callosum anomalies
SO NEUROLOGY
LA English
DT Article
ID DELETION
AB Absence of the corpus callosum is often associated with cognitive deficits, autism, and epilepsy. Using a genomic microarray, the authors analyzed DNA from 25 patients with radiographically confirmed callosal anomalies and identified three patients with de novo copy number changes in chromosome regions 2q37, 6qter, and 8p. Chromosomal deletions and duplications may be a relatively common cause of cerebral malformations.
C1 Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94143 USA.
Univ Calif San Francisco, Dept Pediat, San Francisco, CA 94143 USA.
Univ Calif San Francisco, Inst Canc Res, San Francisco, CA 94143 USA.
Univ Calif San Francisco, Dept Lab Med, San Francisco, CA 94143 USA.
Univ Calif San Francisco, Dept Radiol, San Francisco, CA 94143 USA.
Childrens Hosp Oakland, Oakland, CA USA.
Univ Maine, Orono, ME USA.
RP Sherr, EH (reprint author), Univ Calif San Francisco, Dept Neurol, 533 Parnassus Ave,Box 0748, San Francisco, CA 94143 USA.
EM sherre@neuropeds.ucsf.edu
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NR 10
TC 25
Z9 26
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3261 USA
SN 0028-3878
J9 NEUROLOGY
JI Neurology
PD NOV 8
PY 2005
VL 65
IS 9
BP 1496
EP 1498
DI 10.1212/01.wnl.0000183066.09239.b6
PG 3
WC Clinical Neurology
SC Neurosciences & Neurology
GA 981US
UT WOS:000233114100036
PM 16275846
ER
PT J
AU Heyman, K
AF Heyman, K
TI The autism genetics quandary
SO SCIENTIST
LA English
DT Article
AB Although arguments remain over whether autism is genuinely on the rise to the astonishing degree reported in places like California, there is general agreement among scientists that the condition has a genetic basis. The search for the underlying gene or genes is simultaneously further behind than anyone would like and further ahead than anyone expected.
EM kheyman@the-scientist.com
CR Benayed R, 2005, AM J HUM GENET, V77, P851, DOI 10.1086/497705
Cantor RM, 2005, AM J HUM GENET, V76, P1050, DOI 10.1086/430278
NR 2
TC 1
Z9 1
PU SCIENTIST INC
PI PHILADELPHIA
PA 3535 MARKET ST, SUITE 200, PHILADELPHIA, PA 19104-3385 USA
SN 0890-3670
J9 SCIENTIST
JI Scientist
PD NOV 7
PY 2005
VL 19
IS 21
BP 17
EP 17
PG 1
WC Information Science & Library Science; Multidisciplinary Sciences
SC Information Science & Library Science; Science & Technology - Other
Topics
GA 980LY
UT WOS:000233021200009
ER
PT J
AU Paraguison, RC
Higaki, K
Sakamoto, Y
Hashimoto, O
Miyake, N
Matsumoto, H
Yamamoto, K
Sasaki, T
Kato, N
Nanba, E
AF Paraguison, RC
Higaki, K
Sakamoto, Y
Hashimoto, O
Miyake, N
Matsumoto, H
Yamamoto, K
Sasaki, T
Kato, N
Nanba, E
TI Polyhistidine tract expansions in HOXA1 result in intranuclear
aggregation and increased cell death
SO BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
LA English
DT Article
DE HOXA1; histidine repeat; protein aggregation; ubiquitin; cell death;
diethylpyrocarbonate
ID OCULOPHARYNGEAL MUSCULAR-DYSTROPHY; GLYCERALDEHYDE-3-PHOSPHATE
DEHYDROGENASE; ALLELIC VARIANTS; GENE; AUTISM; ASSOCIATION; INCLUSIONS;
HINDBRAIN; HOXB1; BRAIN
AB HOXA1 gene is part of a cluster of homeotic selector genes that regulates the anteroposterior patterning of mammals during embryonic development. HOXA1 encodes two alternatively spliced mRNAs with two isoforrns, A and B, the former contains the homeodomain and expressed in early embryonic development. HOXA1 contains a string of 10 histidine repeats. However, individuals heterozygous for 7, 9, 11, and 12 histidine repeat variants were present among the Japanese population, notably in some autism cases. To determine the biological implications of the different polyhistidine repeat lengths, we expressed these variants in COS-7 and a human neuroblastoma cell line (SK-N-SH). Expression of expanded variants of HOXA1 isoform A, containing 11 and 12 polyhistidine, resulted in early and great degree of protein aggregation in the nucleus. This aggregation resulted in accelerated cell death in cells expressing I I and 12 expanded variants compared to those transfected with 7 and 10 polyhistidine variants. Furthermore, we showed that these aggregates were ubiquitinated and were inhibited by a histidine-modifying compound, DEPC. These data suggest that HOXA1 protein with polyhistidine tract expansions misfold, aggregate, and have a toxic effect oil cell. (c) 2005 Elsevier Inc. All rights reserved.
C1 Tottori Univ, Div Funct Genom, Res Ctr Biosci & Technol, Yonago, Tottori 6838503, Japan.
Univ Tokyo, Grad Sch Med, Dept Psychiat, Tokyo, Japan.
Nagoya City Univ, Grad Sch Med, Dept Psychiat & Mol Psychiat, Nagoya, Aichi 467, Japan.
Niigata Univ Pharm & Appl Life Sci, Fac Appl Life Sci, Niigata, Japan.
Tokai Univ, Sch Med, Dept Psychiat & Behav Sci, Kanagawa 2591100, Japan.
Kitasato Univ, Sch Med, Dept Psychiat, Sagamihara, Kanagawa, Japan.
RP Nanba, E (reprint author), Tottori Univ, Div Funct Genom, Res Ctr Biosci & Technol, Yonago, Tottori 6838503, Japan.
EM enanba@grape.med.tottori-u.ac.jp
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NR 25
TC 11
Z9 11
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0006-291X
J9 BIOCHEM BIOPH RES CO
JI Biochem. Biophys. Res. Commun.
PD NOV 4
PY 2005
VL 336
IS 4
BP 1033
EP 1039
DI 10.1016/j.bbrc.2005.08.212
PG 7
WC Biochemistry & Molecular Biology; Biophysics
SC Biochemistry & Molecular Biology; Biophysics
GA 973IJ
UT WOS:000232515800007
PM 16168961
ER
PT J
AU Baron-Cohen, S
Knickmeyer, RC
Belmonte, MK
AF Baron-Cohen, S
Knickmeyer, RC
Belmonte, MK
TI Sex differences in the brain: Implications for explaining autism
SO SCIENCE
LA English
DT Article
ID HIGH-FUNCTIONING AUTISM; CONGENITAL ADRENAL-HYPERPLASIA; DEVELOPMENTAL
LANGUAGE DISORDER; FETAL RHESUS-MONKEY; ASPERGER-SYNDROME;
CORPUS-CALLOSUM; ANDROGEN RECEPTORS; MENTAL ROTATION; TEMPORAL-LOBE;
X-CHROMOSOME
AB Empathizing is the capacity to predict and to respond to the behavior of agents (usually people) by inferring their mental states and responding to these with an appropriate emotion. Systemizing is the capacity to predict and to respond to the behavior of nonagentive deterministic systems by analyzing input-operation-output relations and inferring the rules that govern such systems. At a population level, females are stronger empathizers and mates are stronger systemizers. The "extreme male brain" theory posits that autism represents an extreme of the male pattern (impaired empathizing and enhanced systemizing). Here we suggest that specific aspects of autistic neuroanatomy may also be extremes of typical male neuroanatomy.
C1 Univ Cambridge, Autism Res Ctr, Dept Psychiat, Cambridge CB2 2AH, England.
RP Baron-Cohen, S (reprint author), Univ Cambridge, Autism Res Ctr, Dept Psychiat, 18b Trumpington Rd, Cambridge CB2 2AH, England.
EM sb205@cam.ac.uk
RI Knickmeyer, Rebecca/G-8128-2014
OI Knickmeyer, Rebecca/0000-0001-7708-1388
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NR 81
TC 363
Z9 371
PU AMER ASSOC ADVANCEMENT SCIENCE
PI WASHINGTON
PA 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA
SN 0036-8075
J9 SCIENCE
JI Science
PD NOV 4
PY 2005
VL 310
IS 5749
BP 819
EP 823
DI 10.1126/science.1115455
PG 5
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 981XR
UT WOS:000233121800036
PM 16272115
ER
PT J
AU Fitzpatrick, M
AF Fitzpatrick, M
TI The science and fiction of autism
SO NATURE
LA English
DT Book Review
CR Schreibman L., 2005, SCI FICTION AUTISM
NR 1
TC 0
Z9 0
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0028-0836
J9 NATURE
JI Nature
PD NOV 3
PY 2005
VL 438
IS 7064
BP 26
EP 26
DI 10.1038/438026a
PG 1
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 979XS
UT WOS:000232979000021
ER
PT J
AU Dakin, S
Frith, U
AF Dakin, S
Frith, U
TI Vagaries of visual perception in autism
SO NEURON
LA English
DT Review
ID BIOLOGICAL MOTION PERCEPTION; HIGH-FUNCTIONING PERSONS;
ASPERGER-SYNDROME; CENTRAL COHERENCE; RECEPTIVE-FIELDS; APPARENT MOTION;
EYE GAZE; CHILDREN; CORTEX; INTEGRATION
AB Three classes of perceptual phenomena have repeatedly been associated with autism spectrum disorder (ASD): superior processing of fine detail (local structure), either inferior processing of overall/global structure or an ability to ignore disruptive global/contextual information, and impaired motion perception. This review evaluates the quality of the evidence bearing on these three phenomena. We argue that while superior local processing has been robustly demonstrated, conclusions about global processing cannot be definitively drawn from the experiments to date, which have generally not precluded observers using more local cues. Perception of moving stimuli is impaired in ASD, but explanations in terms of magnocellular/dorsal deficits do not appear to be sufficient. We suggest that abnormalities in the superior temporal sulcus (STS) may provide a neural basis for the range of motion-processing deficits observed in ASD, including biological motion perception. Such an explanation may also provide a link between perceptual abnormalities and specific deficits in social cognition associated with autism.
C1 UCL, Inst Ophthalmol, London EC1V 9EL, England.
UCL, Inst Cognit Neurosci, London WC1N 3AR, England.
RP Dakin, S (reprint author), UCL, Inst Ophthalmol, Bath St, London EC1V 9EL, England.
EM s.dakin@ucl.ac.uk
RI Dakin, Steven/B-7610-2008; Frith, Uta/C-1757-2008
OI Frith, Uta/0000-0002-9063-4466
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NR 96
TC 240
Z9 241
PU CELL PRESS
PI CAMBRIDGE
PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA
SN 0896-6273
J9 NEURON
JI Neuron
PD NOV 3
PY 2005
VL 48
IS 3
BP 497
EP 507
DI 10.1016/j.neuron.2005.10.018
PG 11
WC Neurosciences
SC Neurosciences & Neurology
GA 983RP
UT WOS:000233250100010
PM 16269366
ER
PT J
AU Hamilton, SP
Woo, JM
Carlson, EJ
Ghanem, N
Ekker, M
Rubenstein, JLR
AF Hamilton, SP
Woo, JM
Carlson, EJ
Ghanem, N
Ekker, M
Rubenstein, JLR
TI Analysis of four DLX homeobox genes in autistic probands
SO BMC GENETICS
LA English
DT Article
ID PERVASIVE DEVELOPMENTAL DISORDERS; CANDIDATE GENES; LINKAGE; REGION;
EXPRESSION; MUTATIONS; CHROMOSOME-2; FOREBRAIN; NEURONS; ARX
AB Background: Linkage studies in autism have identified susceptibility loci on chromosomes 2q and 7q, regions containing the DLX1/2 and DLX5/6 bigene clusters. The DLX genes encode homeodomain transcription factors that control craniofacial patterning and differentiation and survival of forebrain inhibitory neurons. We investigated the role that sequence variants in DLX genes play in autism by in-depth resequencing of these genes in 161 autism probands from the AGRE collection.
Results: Sequencing of exons, exon/ intron boundaries and known enhancers of DLX1, 2, 5 and 6 identified several nonsynonymous variants in DLX2 and DLX5 and a variant in a DLX5/6intragenic enhancer. The nonsynonymous variants were detected in 4 of 95 families from which samples were sequenced. Two of these four SNPs were not observed in 378 undiagnosed samples from North American populations, while the remaining 2 were seen in one sample each.
Conclusion: Segregation of these variants in pedigrees did not generally support a contribution to autism susceptibility by these genes, although functional analyses may provide insight into the biological understanding of these important proteins.
C1 Univ Calif San Francisco, Dept Psychiat, San Francisco, CA 94143 USA.
Univ Calif San Francisco, Ctr Human Genet, San Francisco, CA 94143 USA.
Univ Calif San Francisco, Genom Core Facil, San Francisco, CA 94143 USA.
Univ Calif San Francisco, Nina Ireland Lab, San Francisco, CA 94143 USA.
Univ Ottawa, Dept Biol, Ottawa, ON, Canada.
RP Rubenstein, JLR (reprint author), Univ Calif San Francisco, Dept Psychiat, San Francisco, CA 94143 USA.
EM steveh@lppi.ucsf.edu; jonwoo@itsa.ucsf.edu; ejcarl@itsa.ucsf.edu;
nghanem@ohri.ca; mekke277@science.uottawa.ca; john.rubenstein@ucsf.edu
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NR 57
TC 40
Z9 41
PU BIOMED CENTRAL LTD
PI LONDON
PA MIDDLESEX HOUSE, 34-42 CLEVELAND ST, LONDON W1T 4LB, ENGLAND
SN 1471-2156
J9 BMC GENET
JI BMC Genet.
PD NOV 2
PY 2005
VL 6
AR 52
DI 10.1186/1471-2156-6-52
PG 11
WC Genetics & Heredity
SC Genetics & Heredity
GA 992OB
UT WOS:000233892300001
PM 16266434
ER
PT J
AU Kuehn, BM
AF Kuehn, BM
TI Children's health study closer to launch - Lack of funding could cause
delays
SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
LA English
DT News Item
AB A massive nationwide children's study that could help answer questions about the role of the environment in birth defects, asthma, diabetes, obesity, autism, and other conditions could begin enrolling participants as early as 2007, ifsufficient federal funding is allocated. The study will monitor 100,000 children from before birth (and in some cases before conception) to age 21 years. Researchers will collect information about the participants' environmental exposures and their health, as well as their genetic background.
NR 0
TC 0
Z9 0
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 515 N STATE ST, CHICAGO, IL 60610 USA
SN 0098-7484
J9 JAMA-J AM MED ASSOC
JI JAMA-J. Am. Med. Assoc.
PD NOV 2
PY 2005
VL 294
IS 17
BP 2154
EP 2154
DI 10.1001/jama.294.17.2154
PG 1
WC Medicine, General & Internal
SC General & Internal Medicine
GA 979PQ
UT WOS:000232957700005
PM 16264151
ER
PT J
AU Benayed, R
Gharani, N
Rossman, I
Mancuso, V
Lazar, G
Kamdar, S
Bruse, SE
Tischfield, S
Smith, BJ
Zimmerman, RA
DiCicco- Bloom, E
Brzustowicz, LM
Millonig, JH
AF Benayed, R
Gharani, N
Rossman, I
Mancuso, V
Lazar, G
Kamdar, S
Bruse, SE
Tischfield, S
Smith, BJ
Zimmerman, RA
DiCicco- Bloom, E
Brzustowicz, LM
Millonig, JH
TI Support for the homeobox transcription factor gene ENGRAILED 2 as an
autism spectrum disorder susceptibility locus
SO AMERICAN JOURNAL OF HUMAN GENETICS
LA English
DT Article
ID SINGLE-NUCLEOTIDE POLYMORPHISMS; CEREBELLAR PURKINJE-CELLS; EARLY
INFANTILE-AUTISM; LINKAGE DISEQUILIBRIUM; GENOMEWIDE SCREEN; BRAIN-STEM;
ASSOCIATION; PATTERNS; IDENTIFICATION; ABNORMALITIES
AB Our previous research involving 167 nuclear families from the Autism Genetic Resource Exchange (AGRE) demonstrated that two intronic SNPs, rs1861972 and rs1861973, in the homeodomain transcription factor gene ENGRAILED 2 (EN2) are significantly associated with autism spectrum disorder (ASD). In this study, significant replication of association for rs1861972 and rs1861973 is reported for two additional data sets: an independent set of 222 AGRE families (rs1861972-rs1861973 haplotype,) and a separate sample of 129 National P=.0016 Institutes of Mental Health families (rs1861972-rs1861973 haplotype,). Association analysis of the P =.0431 haplotype in the combined sample of both AGRE data sets ( 389 families) produced a P value of .0000033, whereas combining all three data sets ( 518 families) produced a P value of .00000035. Population-attributable risk calculations for the associated haplotype, performed using the entire sample of 518 families, determined that the risk allele contributes to as many as 40% of ASD cases in the general population. Linkage disequilibrium (LD) mapping with the use of polymorphisms distributed throughout the gene has shown that only intronic SNPs are in strong LD with rs1861972 and rs1861973. Resequencing and association analysis of all intronic SNPs have identified alleles associated with ASD, which makes them candidates for future functional analysis. Finally, to begin defining the function of EN2 during development, mouse En2 was ectopically expressed in cortical precursors. Fewer En2 transfected cells than controls displayed a differentiated phenotype. Together, these data provide further genetic evidence that EN2 might act as an ASD susceptibility locus, and they suggest that a risk allele that perturbs the spatial/temporal expression of EN2 could significantly alter normal brain development.
C1 Univ Med & Dent New Jersey, Ctr Adv Biotechnol & Med, Robert Wood Johnson Med Sch, Piscataway, NJ 08854 USA.
Univ Med & Dent New Jersey, Dept Neurosci & Cell Biol, Robert Wood Johnson Med Sch, Piscataway, NJ 08854 USA.
Univ Med & Dent New Jersey, New Jersey Med Sch, Dept Psychiat, Newark, NJ 07103 USA.
Rutgers State Univ, Dept Genet, Piscataway, NJ USA.
RP Millonig, JH (reprint author), Univ Med & Dent New Jersey, Ctr Adv Biotechnol & Med, Robert Wood Johnson Med Sch, 679 Hoes Lane, Piscataway, NJ 08854 USA.
EM Millonig@CABM.rutgers.edu
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NR 66
TC 94
Z9 104
PU UNIV CHICAGO PRESS
PI CHICAGO
PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA
SN 0002-9297
J9 AM J HUM GENET
JI Am. J. Hum. Genet.
PD NOV
PY 2005
VL 77
IS 5
BP 851
EP 868
DI 10.1086/497705
PG 18
WC Genetics & Heredity
SC Genetics & Heredity
GA 974CT
UT WOS:000232569600013
PM 16252243
ER
PT J
AU Segurado, R
Conroy, J
Meally, E
Fitzgerald, M
Gill, M
Gallagher, L
AF Segurado, R
Conroy, J
Meally, E
Fitzgerald, M
Gill, M
Gallagher, L
TI Confirmation of association between autism and the mitochondrial
aspartate/glutamate carrier SLC25A12 gene on chromosome 2q31
SO AMERICAN JOURNAL OF PSYCHIATRY
LA English
DT Article
AB Objective: Autism is a neurodevelopmental disorder with childhood onset and a known major genetic component. A recent study identified a highly significant association between autism and a two-single-nucleotide-polymorphism haplotype in the SLC25A12 gene, with a homozygote genotype relative risk between 2.4 and 4.8. The authors' goal was to investigate this association with autism in Irish affected child-parent trios because replication in an independent sample is essential in the validation of such potentially important findings.
Method: Markers rs2056202 and rs2292813 were genotyped in a total of 158 trios ( 442 individuals). The Transmission Disequilibrium Test was used to examine these markers for association with autism.
Results: In agreement with the recent study, the authors found significant association between autism and the C alleles of both rs2056202 and rs2292813 as well as the two-marker haplotype.
Conclusions: These findings provide replication of the association between autism and SLC25A12.
C1 Univ Dublin Trinity Coll, Dept Genet, Dublin 2, Ireland.
Univ Dublin Trinity Coll, Dept Psychiat, Hlth Sci Ctr, Dublin 2, Ireland.
RP Segurado, R (reprint author), Univ Dublin Trinity Coll, Dept Genet, Dublin 2, Ireland.
EM rsegurdo@tcd.ie
RI Segurado, Ricardo/K-6116-2014
OI Segurado, Ricardo/0000-0002-3547-6733
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NR 16
TC 55
Z9 60
PU AMER PSYCHIATRIC PUBLISHING, INC
PI ARLINGTON
PA 1000 WILSON BOULEVARD, STE 1825, ARLINGTON, VA 22209-3901 USA
SN 0002-953X
J9 AM J PSYCHIAT
JI Am. J. Psychiat.
PD NOV
PY 2005
VL 162
IS 11
BP 2182
EP U5
DI 10.1176/appi.ajp.162.11.2182
PG 3
WC Psychiatry
SC Psychiatry
GA 979XF
UT WOS:000232977600030
PM 16263864
ER
PT J
AU Pinto-Martin, JA
Dunkle, M
Earls, M
Fliedner, D
Landes, C
AF Pinto-Martin, JA
Dunkle, M
Earls, M
Fliedner, D
Landes, C
TI Developmental stages of developmental screening: Steps to implementation
of a successful program
SO AMERICAN JOURNAL OF PUBLIC HEALTH
LA English
DT Article
ID PEDIATRIC PRACTICE; AUTISM; DIAGNOSIS; CARE
AB Through the use of 2-stage screening strategies, research studies have shown that autism spectrum disorders and other developmental disabilities can now be detected reliably and with greater validity and in children as young as 18 months of age. Screening and diagnostic practices in the medical and educational arena lag far behind clinical research, however, with the average patient age at time of diagnosis being 3 to 6 years.
We discuss the challenges of instituting universal developmental screening as part of pediatric care and present 2 models of existing or planned programs of early screening for autism spectrum disorder and developmental disability (1 in a community-based setting and 1 in a pediatric setting), and discuss the pros and cons of the different strategies.
C1 Univ Penn, Sch Nursing, Philadelphia, PA 19104 USA.
Penn Ctr Autism & Dev Disabilities Res & Epidemio, Philadelphia, PA 19104 USA.
George Washington Univ, Sch Publ Hlth, Dept Hlth Policy, Washington, DC 20052 USA.
George Washington Univ, Hlth Serv, Washington, DC 20052 USA.
Guilford Child Hlth Inc, Greensboro, NC USA.
Commonwealth Fund Assuring Better Child & Hlth &, New York, NY USA.
Childrens Clin, Long Beach, CA USA.
Cedars Sinai Med Ctr, Los Angeles, CA 90048 USA.
RP Pinto-Martin, JA (reprint author), Univ Penn, Sch Nursing, NEB Room 436,420 Guardian Dr, Philadelphia, PA 19104 USA.
EM pinto@nursing.upenn.edu
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NR 21
TC 39
Z9 40
PU AMER PUBLIC HEALTH ASSOC INC
PI WASHINGTON
PA 800 I STREET, NW, WASHINGTON, DC 20001-3710 USA
SN 0090-0036
J9 AM J PUBLIC HEALTH
JI Am. J. Public Health
PD NOV
PY 2005
VL 95
IS 11
BP 1928
EP 1932
DI 10.2105/AJPH.2004.052167
PG 5
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 980XF
UT WOS:000233050800017
PM 16195523
ER
PT J
AU Sallows, GO
Graupner, TD
AF Sallows, GO
Graupner, TD
TI Intensive behavioral treatment for children with autism: Four-year
outcome and predictors
SO AMERICAN JOURNAL ON MENTAL RETARDATION
LA English
DT Article
ID PERVASIVE DEVELOPMENTAL DISORDER; YOUNG-CHILDREN; FOLLOW-UP; EARLY
INTERVENTION; JOINT ATTENTION; LANGUAGE; REGRESSION; AGE; INTELLIGENCE;
PRESCHOOL
AB Twenty-four children with autism were randomly assigned to a clinic-directed group, replicating the parameters of the early intensive behavioral treatment developed at UCLA, or to a parent-directed group that received intensive hours but less supervision by equally well-trained supervisors. Outcome after 4 years of treatment, including cognitive, language, adaptive, social, and academic measures, was similar for both groups. After combining groups, we found that 48% of all children showed rapid learning, achieved average post-treatment scores, and at age 7, were succeeding in regular education classrooms. Treatment outcome was best predicted by pretreatment imitation, language, and social responsiveness. These results are consistent with those reported by Lovaas and colleagues.
C1 Wisconsin Early Autsm Project, Madison, WI 53719 USA.
RP Sallows, GO (reprint author), Wisconsin Early Autsm Project, 6402 Odana Rd, Madison, WI 53719 USA.
EM weap@wiautism.com
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NR 74
TC 224
Z9 226
PU AMER ASSOC MENTAL RETARDATION
PI WASHINGTON
PA 444 N CAPITOL ST, NW, STE 846, WASHINGTON, DC 20001-1512 USA
SN 0895-8017
J9 AM J MENT RETARD
JI Am. J. Ment. Retard.
PD NOV
PY 2005
VL 110
IS 6
BP 417
EP 438
DI 10.1352/0895-8017(2005)110[417:IBTFCW]2.0.CO;2
PG 22
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA 983CE
UT WOS:000233207900001
PM 16212446
ER
PT J
AU Goeb, JL
Mouren, MC
AF Goeb, JL
Mouren, MC
TI The place of psychotropic drugs in the treatment of autism of children
and adolescents
SO ANNALES MEDICO-PSYCHOLOGIQUES
LA English
DT Article
ID PERVASIVE DEVELOPMENTAL DISORDERS; DEFICIT HYPERACTIVITY DISORDER;
WHOLE-BLOOD SEROTONIN; DOUBLE-BLIND; INFANTILE-AUTISM; OPEN TRIAL;
CONTROLLED CROSSOVER; BEHAVIORAL SYMPTOMS; FLUID LEVELS; ADULTS
C1 CHRU, Ctr Reference Reg Troubles Dev, Serv Pedopsychiat Pr Delion, F-59037 Lille, France.
Hop Robert Debre, F-75019 Paris, France.
RP Goeb, JL (reprint author), CHRU, Ctr Reference Reg Troubles Dev, Serv Pedopsychiat Pr Delion, F-59037 Lille, France.
EM jlgoeb@wanadoo.fr
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NR 68
TC 1
Z9 1
PU MASSON EDITEUR
PI MOULINEAUX CEDEX 9
PA 21 STREET CAMILLE DESMOULINS, ISSY, 92789 MOULINEAUX CEDEX 9, FRANCE
SN 0003-4487
J9 ANN MED-PSYCHOL
JI Ann. Med.-Psychol.
PD NOV
PY 2005
VL 163
IS 9
BP 791
EP 801
DI 10.1016/S0003-4487(05)00213-1
PG 11
WC Pharmacology & Pharmacy; Psychiatry; Psychology; Psychology,
Multidisciplinary
SC Pharmacology & Pharmacy; Psychiatry; Psychology
GA 989IF
UT WOS:000233665400014
ER
PT J
AU Aman, MG
Arnold, LE
Ramadan, Y
Witwer, A
Lindsay, R
McDougle, CJ
Posey, DJ
Swiezy, N
Kohn, A
McCracken, JT
Shah, B
Cronin, P
McGough, J
Lee, JSY
Scahill, L
Martin, A
Koenig, K
Carroll, D
Young, C
Lancor, A
Tierney, E
Ghuman, J
Gonzalez, NM
Grados, M
Vitiello, B
Ritz, L
Chuang, S
Davies, M
Robinson, J
McMahon, D
AF Aman, MG
Arnold, LE
Ramadan, Y
Witwer, A
Lindsay, R
McDougle, CJ
Posey, DJ
Swiezy, N
Kohn, A
McCracken, JT
Shah, B
Cronin, P
McGough, J
Lee, JSY
Scahill, L
Martin, A
Koenig, K
Carroll, D
Young, C
Lancor, A
Tierney, E
Ghuman, J
Gonzalez, NM
Grados, M
Vitiello, B
Ritz, L
Chuang, S
Davies, M
Robinson, J
McMahon, D
CA Res Units Pediat Psychopharmacolo
TI Randomized, controlled, crossover trial of methylphenidate in pervasive
developmental disorders with hyperactivity
SO ARCHIVES OF GENERAL PSYCHIATRY
LA English
DT Article; Proceedings Paper
CT 42nd Meeting of the American-College-of-Neuropsychopharmacology
CY DEC 07-11, 2003
CL San Juan, PR
SP Amer Coll Neuropsychopharmacol
ID MENTAL-RETARDATION; SCHIZOPHRENIC CHILDREN; BORDERLINE IQ; AUTISM;
FENFLURAMINE; INDIVIDUALS; EFFICACY; ADHD; MTA
AB Context: Hyperactivity and inattention are common symptoms in children with autistic disorder and related pervasive developmental disorders, but studies of stimulants in these conditions have been inconclusive.
Objectives: To determine the efficacy and safety of methylphenidate hydrochloride in children with pervasive developmental disorders and hyperactivity.
Design: Double-blind, placebo-controlled, crossover trial followed by open-label continuation.
Setting: Five academic outpatient clinics.
Participants: Seventy-two drug-free children, aged 5 to 14 years, with pervasive developmental disorders accompanied by moderate to severe hyperactivity.
Interventions: Prior to randomization, subjects entered a 1-week test-dose phase in which each subject received placebo for 1 day followed by increasing doses of methylphenidate (low, medium, and high doses) that were each given for 2 days. The low, medium, and high doses of methylphenidate hydrochloride were based on weight, and they ranged from 7.5 mg/d to 50.0 mg/d in divided doses. Subjects who tolerated the test dose (n=66) were assigned to receive placebo for 1 week and then 3 methylphenidate doses in random order during a double-blind, crossover phase. Children responding to methylphenidate then entered 8 weeks of open-label treatment at the individually determined best dose.
Main Outcome Measures: The primary outcome measure was the teacher-rated hyperactivity subscale of the Aberrant Behavior Checklist. Response was defined as "much improved" or "very much-improved" on the Clinical Global Impressions Improvement item coupled with considerable reductions in the parent-rated and/or teacher-rated Aberrant Behavior Checklist hyperactivity subscale score.
Results: Methylphenidate was superior to placebo on the primary outcome measure, with effect sizes ranging from 0.20 to 0.54 depending on dose and rater. Thirty-five (49%) of 72 enrolled subjects were classified as methylphenidate responders. Adverse effects led to the discontinuation of study medication in 13 (18%) of 72 subjects.
Conclusions: Methylphenidate was often efficacious in treating hyperactivity associated with pervasive developmental disorders, but the magnitude of response was less than that seen in typically developing children with attention-deficit/hyperactivity disorder. Adverse effects were more frequent.
C1 James Whitcomb Riley Hosp Children, Indianapolis, IN 46202 USA.
Ohio State Univ, Columbus, OH 43210 USA.
Indiana Univ, Indianapolis, IN 46204 USA.
Univ Calif Los Angeles, Los Angeles, CA 90024 USA.
Yale Univ, New Haven, CT 06520 USA.
Kennedy Krieger Inst, Baltimore, MD USA.
NIMH, Bethesda, MD 20892 USA.
Columbia Univ, New York, NY 10027 USA.
Nathan S Kline Inst Psychiat Res, Orangeburg, NY 10962 USA.
RP Posey, DJ (reprint author), James Whitcomb Riley Hosp Children, Room 4300,702 Barnhill Dr, Indianapolis, IN 46202 USA.
EM dposey@iupui.edu
CR Aman M., 1994, ABERRANT BEHAV CHECK
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Volkmar F. R., 1997, HDB AUTISM PERVASIVE, P5
NR 27
TC 171
Z9 174
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA
SN 0003-990X
EI 1538-3636
J9 ARCH GEN PSYCHIAT
JI Arch. Gen. Psychiatry
PD NOV
PY 2005
VL 62
IS 11
BP 1266
EP 1274
PG 9
WC Psychiatry
SC Psychiatry
GA 980XG
UT WOS:000233050900010
ER
PT J
AU Kees, EK
Hefter, RL
Klaver, J
Schweigert, SA
Arneson, CL
Gernsbacher, MA
Goldsmith, HH
AF Kees, EK
Hefter, RL
Klaver, J
Schweigert, SA
Arneson, CL
Gernsbacher, MA
Goldsmith, HH
TI Twin concordance for the autism spectrum based on community diagnoses
and screening of a birth cohort
SO BEHAVIOR GENETICS
LA English
DT Meeting Abstract
CT 35th Annual Meeting of the Behavior-Genetics-Association
CY JUN 29-JUL 02, 2005
CL Hollywood, CA
SP Behav Genet Assoc
C1 Univ Wisconsin, Waisman Ctr, Madison, WI 53705 USA.
EM ekkees@wisc.edu
NR 0
TC 2
Z9 2
PU SPRINGER
PI NEW YORK
PA 233 SPRING STREET, NEW YORK, NY 10013 USA
SN 0001-8244
J9 BEHAV GENET
JI Behav. Genet.
PD NOV
PY 2005
VL 35
IS 6
BP 808
EP 808
PG 1
WC Behavioral Sciences; Genetics & Heredity; Psychology, Multidisciplinary
SC Behavioral Sciences; Genetics & Heredity; Psychology
GA 985PZ
UT WOS:000233391600068
ER
PT J
AU Allen, G
AF Allen, G
TI Functional magnetic resonance imaging in autism: Foundations and
implications of cerebellar dysfunction
SO BEHAVIOR GENETICS
LA English
DT Meeting Abstract
CT 35th Annual Meeting of the Behavior-Genetics-Association
CY JUN 29-JUL 02, 2005
CL Hollywood, CA
SP Behav Genet Assoc
C1 Univ Texas, SW Med Ctr, Dept Psychiat, Dallas, TX 75216 USA.
EM greg.allen@utsouthwestern.edu
NR 0
TC 0
Z9 0
PU SPRINGER
PI NEW YORK
PA 233 SPRING STREET, NEW YORK, NY 10013 USA
SN 0001-8244
J9 BEHAV GENET
JI Behav. Genet.
PD NOV
PY 2005
VL 35
IS 6
BP 827
EP 828
PG 2
WC Behavioral Sciences; Genetics & Heredity; Psychology, Multidisciplinary
SC Behavioral Sciences; Genetics & Heredity; Psychology
GA 985PZ
UT WOS:000233391600134
ER
PT J
AU MacDonald, R
Clark, M
Garrigan, E
Vangala, M
AF MacDonald, R
Clark, M
Garrigan, E
Vangala, M
TI Using video modeling to teach pretend play to children with autism
SO BEHAVIORAL INTERVENTIONS
LA English
DT Article
ID PERSPECTIVE-TAKING; SKILLS
AB Children with autism often fail to develop the rich repertoires of pretend play seen in typically developing children. Video modeling is a teaching methodology that has been shown to produce rapid acquisition of a variety of skills in children with autism. The purpose of the present study was to use video modeling to teach thematic pretend play skills to two preschool children with autism. Scripted play scenarios involving up to 17 verbalizations and 15 play actions by toy figurines were videotaped using adult models. A multiple probe design within child across play sets was used to demonstrate experimental control. Children were shown the video model two times and no further prompting or reinforcement was delivered during training. Results indicated that both children acquired the sequences of scripted verbalizations and play actions quickly and maintained this performance during follow-up probes. These findings are discussed as they relate to types of play and the development of extended play repertoires in young children with autism. Copyright (c) 2005 John Wiley & Sons, Ltd.
C1 New England Ctr Children, Southborough, MA 01772 USA.
RP MacDonald, R (reprint author), New England Ctr Children, 33 Turnpike Rd, Southborough, MA 01772 USA.
EM bmacdonald@necc.org
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NR 14
TC 43
Z9 43
PU JOHN WILEY & SONS LTD
PI CHICHESTER
PA THE ATRIUM, SOUTHERN GATE, CHICHESTER PO19 8SQ, W SUSSEX, ENGLAND
SN 1072-0847
J9 BEHAV INTERVENT
JI Behav. Intervent.
PD NOV
PY 2005
VL 20
IS 4
BP 225
EP 238
DI 10.1002/bin.197
PG 14
WC Psychology, Clinical
SC Psychology
GA 989XM
UT WOS:000233707400001
ER
PT J
AU Taylor, BA
Hoch, H
Weissman, M
AF Taylor, BA
Hoch, H
Weissman, M
TI The analysis and treatment of vocal stereotypy in a child with autism
SO BEHAVIORAL INTERVENTIONS
LA English
DT Article
ID SELF-INJURIOUS-BEHAVIOR; NONCONTINGENT SENSORY REINFORCEMENT;
FUNCTIONAL-ANALYSIS; AUTOMATIC REINFORCEMENT; DIFFERENTIAL
REINFORCEMENT; DEVELOPMENTAL-DISABILITIES; EXTINCTION; DRO;
VOCALIZATIONS; CHOICE
AB This study examined procedures for the assessment and treatment of automatically reinforced vocal stereotypy of a 6-year-old girl with autism. Stimulus assessments were conducted to identify toys that were correlated with higher rates of vocal stereotypy and toys that were not. A concurrent operants assessment identified preferred stimuli (toys that produced auditory stimulation), which were then used as reinforcers for the non-occurrence of vocal stereotypy. A reversal design was used to compare the effects of a fixed time schedule of reinforcement (FT 1-min) to differential reinforcement for the non-occurrence of behavior (DRO) to reduce vocal stereotypy. Implementation of the FT schedule revealed no effect, whereas the DRO schedule led to a reduction in the target behavior during treatment sessions and across the school day. This study adds to the body of literature supporting the identification of matched stimuli to reduce non-socially mediated problem behavior. Copyright (c) 2005 John Wiley & Sons, Ltd.
C1 Alpine Learning Grp, Paramus, NJ USA.
CUNY, Grad Ctr, New York, NY 10021 USA.
RP Taylor, BA (reprint author), 777 Paramus Rd, Paramus, NJ 07652 USA.
EM btaylor@alpinelearninggroup.org
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NR 27
TC 37
Z9 37
PU JOHN WILEY & SONS LTD
PI CHICHESTER
PA THE ATRIUM, SOUTHERN GATE, CHICHESTER PO19 8SQ, W SUSSEX, ENGLAND
SN 1072-0847
J9 BEHAV INTERVENT
JI Behav. Intervent.
PD NOV
PY 2005
VL 20
IS 4
BP 239
EP 253
DI 10.1002/bin.200
PG 15
WC Psychology, Clinical
SC Psychology
GA 989XM
UT WOS:000233707400002
ER
PT J
AU Chong, IM
Carr, JE
AF Chong, IM
Carr, JE
TI An investigation of the potentially adverse effects of task interspersal
SO BEHAVIORAL INTERVENTIONS
LA English
DT Article
ID AUTISTIC-CHILDREN; REINFORCEMENT; MAINTENANCE; ACQUISITION
AB This series of experiments sought to replicate the findings by Charlop, Kurtz, and Milstein (1992) in which presenting the same consequences for maintenance (previously learned tasks) and nonacquired tasks was found to impede learning of the latter during task interspersal. In Experiment 1, we conducted a systematic replication with three children diagnosed with autism. All participants reached mastery criteria for the nonacquired tasks, even though the same consequences were delivered for maintenance and nonacquired tasks. In Experiment 2, we conducted a direct replication of the Charlop et al. (1992) with the same children from Experiment 1. In four of five evaluations, participants reached mastery criterion for the nonacquired task, even though same consequences were provided for maintenance and nonacquired tasks. The results are discussed in the context of the differences between studies that might have contributed to the discrepant findings. Copyright (c) 2005 John Wiley & Sons, Ltd.
C1 Western Michigan Univ, Dept Psychol, Kalamazoo, MI 49008 USA.
RP Carr, JE (reprint author), Western Michigan Univ, Dept Psychol, 1903 W Michigan Ave, Kalamazoo, MI 49008 USA.
EM jim.carr@wmich.edu
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NR 22
TC 5
Z9 5
PU JOHN WILEY & SONS LTD
PI CHICHESTER
PA THE ATRIUM, SOUTHERN GATE, CHICHESTER PO19 8SQ, W SUSSEX, ENGLAND
SN 1072-0847
J9 BEHAV INTERVENT
JI Behav. Intervent.
PD NOV
PY 2005
VL 20
IS 4
BP 285
EP 300
DI 10.1002/bin.202
PG 16
WC Psychology, Clinical
SC Psychology
GA 989XM
UT WOS:000233707400005
ER
PT J
AU Budden, SS
Dorsey, HC
Steiner, RD
AF Budden, SS
Dorsey, HC
Steiner, RD
TI Clinical profile of a male with Rett syndrome
SO BRAIN & DEVELOPMENT
LA English
DT Article; Proceedings Paper
CT 2nd International Scientific Research Workshop on From Basic
Neuroscience to Habilitation and Treatment Infant Behavior
CY JUN, 2003
CL Froson, SWEDEN
SP Swedish Rett Ctr
DE male; MECP2 mutation; recurrent Rett syndrome; autism; gall bladder;
osteoporosis
ID DIAGNOSTIC-CRITERIA; MUTATION ANALYSIS; MECP2 GENE; FEMALES
AB We describe a clinical profile of a male with Rett syndrome who presented initially with significant axial and peripheral hypotonia, head and truncal titubation and global delay. He is non-ambulatory, lost the few words he had learned and gradually developed hand stereotypes, breathing difficulties, seizures, scoliosis and has osteoporosis sleep problems and sludging in his gall bladder. Prior to diagnosis he underwent comprehensive neurological, metabolic and genetic investigations. After his older sister was diagnosed with atypical Rett syndrome; MECP2 mutation studies on him revealed a pathogenic mutation. His mother is a Rett carrier with a skewed inactivation of chromosome X. Clinical signs and symptoms required to meet the criteria for diagnosis of Rett syndrome have gradually evolved over time. This case demonstrates an unusual family history for Rett syndrome and alerts readers to the utility of screening males for Rett syndrome. (c) 2005 Elsevier B.V. All rights reserved.
C1 Oregon Hlth Sci Univ, Dept Pediat, Child Dev & Rehabil Ctr, Doernbecher Childrens Hosp, Portland, OR 97239 USA.
Oregon Hlth Sci Univ, Dept Obstet & Gynecol, Ctr Womens Hlth, Doernbecher Childrens Hosp, Portland, OR 97239 USA.
Oregon Hlth Sci Univ, Dept Mol & Med Genet, Child Dev & Rehabil Ctr, Doernbecher Childrens Hosp, Portland, OR 97239 USA.
RP Budden, SS (reprint author), Oregon Hlth Sci Univ, Dept Pediat, Child Dev & Rehabil Ctr, Doernbecher Childrens Hosp, CDRC 707 SW Gaines Rd, Portland, OR 97239 USA.
EM sbudden@comcast.net
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NR 14
TC 16
Z9 16
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0387-7604
J9 BRAIN DEV-JPN
JI Brain Dev.
PD NOV
PY 2005
VL 27
SU 1
BP S69
EP S71
DI 10.1016/j.braindev.2005.03.018
PG 3
WC Clinical Neurology
SC Neurosciences & Neurology
GA 001SV
UT WOS:000234557500011
PM 16182490
ER
PT J
AU Einspieler, C
Kerr, AM
Prechtl, HFR
AF Einspieler, C
Kerr, AM
Prechtl, HFR
TI Abnormal general movements in girls with Rett disorder: The first four
months of life
SO BRAIN & DEVELOPMENT
LA English
DT Article; Proceedings Paper
CT 2nd International Scientific Research Workshop on From Basic
Neuroscience to Habilitation and Treatment Infant Behavior
CY JUN, 2003
CL Froson, SWEDEN
SP Swedish Rett Ctr
DE fidgety movements; generalised movements; infant; spontaneous movements;
video analysis
ID PRETERM INFANTS; CEREBRAL-PALSY; QUALITATIVE CHANGES; BRAIN-LESIONS;
TERM INFANTS; EARLY MARKER; SIGNS; BEHAVIOR; AUTISM
AB An apparently normal early development was one of the initial criteria for classical Rett syndrome. However, several investigators considered Rett syndrome to be a developmental disorder manifesting very soon after birth. Videos of 14 infants with Rett disorder were carefully assessed for their spontaneous movements, in particular general movements (GMs), during the first 4 months of life. A detailed analysis clearly demonstrated that none of the infants had normal GMs. However, a specific abnormal GM pattern could not be detected for Rett disorder. The abnormal GMs described here, and their individual developmental trajectories are different from the abnormal GMs described in infants with acquired brain lesion. Our study is the first to apply specific standardised measures of early spontaneous movements to infants with Rett syndrome, proving conclusively that the disorder is manifest within the first weeks of life. (c) 2005 Elsevier B.V. All rights reserved.
C1 Graz Univ, Inst Physiol, Ctr Physiol Med, Sect Dev Physiol & Dev Neurol, A-8010 Graz, Austria.
Gartnavel Royal Hosp, Acad Ctr, Dept Med Psychol, Glasgow G12 0YN, Lanark, Scotland.
RP Einspieler, C (reprint author), Graz Univ, Inst Physiol, Ctr Physiol Med, Sect Dev Physiol & Dev Neurol, Harrachgasse 21, A-8010 Graz, Austria.
EM christa.einspieler@meduni-graz.at
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NR 40
TC 31
Z9 33
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0387-7604
J9 BRAIN DEV-JPN
JI Brain Dev.
PD NOV
PY 2005
VL 27
SU 1
BP S8
EP S13
DI 10.1016/j.braindev.2005.03.014
PG 6
WC Clinical Neurology
SC Neurosciences & Neurology
GA 001SV
UT WOS:000234557500003
PM 16182501
ER
PT J
AU Nomura, Y
AF Nomura, Y
TI Early behavior characteristics and sleep disturbance in Rett syndrome
SO BRAIN & DEVELOPMENT
LA English
DT Article; Proceedings Paper
CT 2nd International Scientific Research Workshop on From Basic
Neuroscience to Habilitation and Treatment Infant Behavior
CY JUN, 2003
CL Froson, SWEDEN
SP Swedish Rett Ctr
DE Rett syndrome; early behavior; autistic behavior; sleep-wake rhythm;
sleep components; monoamine; serotonin; dopamine; noradrenaline
ID DIFFERENTIAL-DIAGNOSIS; BRAIN-DEVELOPMENT; AUTISM; DISORDERS; CORTEX;
ABNORMALITIES; MUTATIONS; SYMPTOMS; GROWTH; MOTOR
AB This paper reviews the early features of Rett syndrome (RTT). The behavioral characteristics of RTT were analyzed retrospectively by taking history and asking about early infancy behaviors. The earliest behavioral characteristics are thought to be autistic features and hypotonia of trunkal muscles. Analysis of sleep-wake rhythm and all-night polysomnography suggested that the initial lesion is serotonergic and noradrenargic hypofunction at brainstem level. Dopaminergic (DA) hypofunction associated with DA receptor supersensitivity follows as the brain matures. Characteristic symptoms developing at specific age ranges are based on the neuronal connections of the brainstem aminergic neurons and DA neurons with the pedunculo-pontine nuclei, projecting to specific cortical areas. (c) 2005 Elsevier B.V. All rights reserved.
C1 Segawa Neurol Clin Children, Tokyo 1010062, Japan.
RP Nomura, Y (reprint author), Segawa Neurol Clin Children, 2-8 Surugadai Kanda Chiyodaku, Tokyo 1010062, Japan.
EM nomura-y@segawa-clinic.jp
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NR 67
TC 25
Z9 25
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0387-7604
J9 BRAIN DEV-JPN
JI Brain Dev.
PD NOV
PY 2005
VL 27
SU 1
BP S35
EP S42
DI 10.1016/j.braindev.2005.03.017
PG 8
WC Clinical Neurology
SC Neurosciences & Neurology
GA 001SV
UT WOS:000234557500007
PM 16182496
ER
PT J
AU Trevarthen, C
Daniel, S
AF Trevarthen, C
Daniel, S
TI Disorganized rhythm and synchrony: Early signs of autism and Rett
syndrome
SO BRAIN & DEVELOPMENT
LA English
DT Article; Proceedings Paper
CT 2nd International Scientific Research Workshop on From Basic
Neuroscience to Habilitation and Treatment Infant Behavior
CY JUN, 2003
CL Froson, SWEDEN
SP Swedish Rett Ctr
DE autism; Rett syndrome; infancy; intersubjectivity; therapy
ID SPECTRUM DISORDER; HOME MOVIES; EARLY RECOGNITION; MENTAL-HEALTH; AGE;
DIAGNOSIS; CHILDREN; COMMUNICATION; VIDEOTAPES; INFANTS
AB We interpret early age-related developments in intentions and socially responsive behaviour with data from home videos of infants who later develop autism or Rett syndrome. Detailed evidence is given from a micro-analytic study of videos of monozygotic twin girls at I I months, one of whom became autistic in the second year. Changes in this twin's attention, motor tonus, initiative and emotion reduce her prospective control of movements and her anticipations in awareness compared to her sister. These changes were reflected in the child's asynchronous social behaviour, which frustrated the father's attempts to support her attempts to walk, share toys, or play a game, confusing his anticipations, and this further reduced mutual attention and joint activity. Observations of the development of girls with Rett syndrome in the first year reveal changes in motor coordination, attention and communicative initiative, indicative of a failure of intrinsic core brain regulations of neural development and conscious activity. Notwithstanding that the two conditions show clear differences in both brain growth and early development of skills and sociability, the first signs of autism and Rett syndrome have important similarities. We conclude with recommendations for an approach to early diagnosis and treatment, applicable for the whole range of developmental brain disorders, including Rett syndrome and autism, that attempts to identify residual capacities for sympathetic motivation and collaborative learning-an approach that deliberately tries to support weakened rhythmic impulses for motor, perceptual and communicative functions in the growing infant brain. (c) 2005 Elsevier B.V. All rights reserved.
C1 Univ Edinburgh, Dept Psychol, Edinburgh EH8 9JZ, Midlothian, Scotland.
RP Trevarthen, C (reprint author), Univ Edinburgh, Dept Psychol, 1 George Sq, Edinburgh EH8 9JZ, Midlothian, Scotland.
EM c.trevarthen@ed.ac.uk
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NR 67
TC 31
Z9 33
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0387-7604
J9 BRAIN DEV-JPN
JI Brain Dev.
PD NOV
PY 2005
VL 27
SU 1
BP S25
EP S34
DI 10.1016/j.braindev.2005.03.016
PG 10
WC Clinical Neurology
SC Neurosciences & Neurology
GA 001SV
UT WOS:000234557500006
PM 16182487
ER
PT J
AU Altgassen, M
Kliegel, M
Williams, TI
AF Altgassen, M
Kliegel, M
Williams, TI
TI Pitch perception in children with autistic spectrum disorders
SO BRITISH JOURNAL OF DEVELOPMENTAL PSYCHOLOGY
LA English
DT Article
ID ASPERGERS-DISORDER; CLINICAL SYMPTOMS; CENTRAL COHERENCE; MIND;
INTERFERENCE; INDIVIDUALS; PERFORMANCE; ABILITY; MEMORY; SAVANT
AB This study investigated the accuracy of musical pitch detection in children with autistic spectrum disorders as compared with typically developing children. Seventeen children on the autistic spectrum (M-age = 9.34, SDage = 1.12) and 13 typically developing, chronological age-matched children (M-age = 9.13, SDage = 1.68) took part in the current study. Children were required to listen to four tones, which were paired with four different pictures and asked to learn the combinations. The children were then assessed for their ability to identify the previously learned tones, when they were presented as single tones and when they were embedded in chords and discords. No significant group differences were found. However, after subdividing the clinical group according to their diagnosis of autism or Asperger's syndrome, the results indicated a slightly superior disembedding ability in participants with Asperger's syndrome. The findings are discussed in terms of the weak central coherence concept.
C1 Univ Zurich, Dept Psychol, CH-8032 Zurich, Switzerland.
Univ Heidelberg, D-6900 Heidelberg, Germany.
Univ Reading, Reading RG6 2AH, Berks, England.
RP Kliegel, M (reprint author), Univ Zurich, Dept Psychol, Freiensteinstr 5, CH-8032 Zurich, Switzerland.
EM m.kliegel@psychologie.unizh.ch
RI Williams, Timothy/D-3512-2011; Altgassen, Mareike/J-3048-2012
OI Williams, Timothy/0000-0003-0072-3316;
CR American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th
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World Health Organisation (WHO), 1993, INT CLASS DIS
NR 44
TC 11
Z9 12
PU BRITISH PSYCHOLOGICAL SOC
PI LEICESTER
PA ST ANDREWS HOUSE, 48 PRINCESS RD EAST, LEICESTER LE1 7DR, LEICS, ENGLAND
SN 0261-510X
J9 BRIT J DEV PSYCHOL
JI Br. J. Dev. Psychol.
PD NOV
PY 2005
VL 23
BP 543
EP 558
DI 10.1348/026151005X26840
PN 4
PG 16
WC Psychology, Developmental
SC Psychology
GA 988BY
UT WOS:000233567600007
PM 21214596
ER
PT J
AU Striano, T
Bertin, E
AF Striano, T
Bertin, E
TI Brief report - Social-cognitive skills between 5 and 10 months of age
SO BRITISH JOURNAL OF DEVELOPMENTAL PSYCHOLOGY
LA English
DT Article
ID JOINT ATTENTION; GAZE; AUTISM; 6-MONTH-OLDS; CHILDREN; INFANCY; EYES
AB joint attention skills are an important part of human cultural learning. However, little is known about the emergence and meaning of these skills in early ontogeny. The development of, and relation among, various joint attention skills was assessed. Seventy-two 5 to 10-month-old infants were tested on a variety of joint attention tasks. Intercorrelations among these tasks were sparse, which puts into question the meaning of these various skills. In addition, the majority of infants exhibited some joint attention skill before 9 months of age, which points to a more gradual development of joint attention skills than suggested by previous research.
C1 Max Planck Inst Evolut Anthropol, Leipzig, Germany.
RP Striano, T (reprint author), Max Planck Inst Human Cognit & Brain Sci, Neurocognit & Dev Grp, Otto Schill Str 1a, D-04109 Leipzig, Germany.
EM striano@cbs.mpg.de
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NR 28
TC 8
Z9 8
PU BRITISH PSYCHOLOGICAL SOC
PI LEICESTER
PA ST ANDREWS HOUSE, 48 PRINCESS RD EAST, LEICESTER LE1 7DR, LEICS, ENGLAND
SN 0261-510X
J9 BRIT J DEV PSYCHOL
JI Br. J. Dev. Psychol.
PD NOV
PY 2005
VL 23
BP 559
EP 568
DI 10.1348/026151005X26282
PN 4
PG 10
WC Psychology, Developmental
SC Psychology
GA 988BY
UT WOS:000233567600008
PM 21214597
ER
PT J
AU Toal, F
Murphy, DGM
Murphy, KC
AF Toal, F
Murphy, DGM
Murphy, KC
TI Autistic-spectrum disorders: lessons from neuroimaging
SO BRITISH JOURNAL OF PSYCHIATRY
LA English
DT Editorial Material
ID ASPERGER-SYNDROME; BRAIN-DEVELOPMENT; INTERCORRELATIONS; FACES
AB Autistic-spectrum disorder is approximately half as common as schizophrenia but its cause remains unknown. Recent studies have begun to clarify the underlying neuroanatomical abnormalities and brain-behaviour relationships in autism. In the past decade, great advances have been made in our understanding of the neurobiological basis of autism.
C1 Beaumont Hosp, Royal Coll Surg Ireland, Dept Psychiat, Dublin 9, Ireland.
Inst Psychiat, Dept Psychol Med, London SE5 8AF, England.
RP Toal, F (reprint author), Beaumont Hosp, Royal Coll Surg Ireland, Dept Psychiat, Dublin 9, Ireland.
EM ftoal@rcsi.ie
RI Murphy, Kieran/D-3577-2012
CR American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th
[Anonymous], 1992, INT STAT CLASS DIS R
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NR 22
TC 20
Z9 20
PU ROYAL COLLEGE OF PSYCHIATRISTS
PI LONDON
PA BRITISH JOURNAL OF PSYCHIATRY 17 BELGRAVE SQUARE, LONDON SW1X 8PG,
ENGLAND
SN 0007-1250
J9 BRIT J PSYCHIAT
JI Br. J. Psychiatry
PD NOV
PY 2005
VL 187
BP 395
EP 397
DI 10.1192/bjp.187.5.395
PG 3
WC Psychiatry
SC Psychiatry
GA 981NO
UT WOS:000233095500002
PM 16260811
ER
PT J
AU Hobson, RP
Meyer, JA
AF Hobson, RP
Meyer, JA
TI Foundations for self and other: a study in autism
SO DEVELOPMENTAL SCIENCE
LA English
DT Article
ID JOINT ATTENTION; CHILDREN; MIND; IMITATION; RECOGNITION; LANGUAGE;
INFANTS; ACQUISITION; EMOTIONS; DEFICITS
AB There is controversy over the basis for young children's experience of themselves and other people as separate yet related individuals, each with a mental perspective oil the world - and over the nature of corresponding deficits in autism. Here we tested a form of self-other connectedness (identification) in children with and without autism, who were group-matched according to CA (approximately 6 to 16 years) and verbal MA (approximately 21/2 to 14 years), and therefore IQ. We gave two forms. 2 of a novel 'sticker test' in which children needed to communicate to another person where oil her body she should place her sticker-badge. Across the trials of Study 1, all of the non-autistic children pointed to their own bodies at least once, but over half the children with autism failed to point to themselves at all, even though they communicated successfully in other ways. In Study 2, where a screen was introduced to hide the tester's body, group differences in the children's communicative self-orientated gestures were most marked after the tester had 'modelled' a point-to-herself gesture in communicating to the child. Our interpretation is that autism involves a relative failure to adopt the bodily-anchored psychological and communicative stance Of another person. We suggest that this process of identification is essential to self-other relations and grounds young children's developing understanding of minds.
C1 Tavistock Clin, Dev Psychopathol Res Unit, London NW3 5BA, England.
UCL, Inst Child Hlth, London WC1E 6BT, England.
RP Hobson, RP (reprint author), Tavistock Clin, Dev Psychopathol Res Unit, 120 Belsize Lane, London NW3 5BA, England.
EM r.hobson@ucl.ac.uk
CR American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th
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NR 61
TC 37
Z9 39
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 1363-755X
J9 DEVELOPMENTAL SCI
JI Dev. Sci.
PD NOV
PY 2005
VL 8
IS 6
BP 481
EP 491
DI 10.1111/j.1467-7687.2005.00439.x
PG 11
WC Psychology, Developmental; Psychology, Experimental
SC Psychology
GA 982IV
UT WOS:000233152200007
PM 16246239
ER
PT J
AU Striano, T
Henning, A
Stahl, D
AF Striano, T
Henning, A
Stahl, D
TI Sensitivity to social contingencies between 1 and 3 months of age
SO DEVELOPMENTAL SCIENCE
LA English
DT Article
ID INFANTS PREFERENCE; YOUNG INFANTS; SELF; PERCEPTION; AUTISM; MOTHER
AB Infants' sensitivity to social contingencies was assessed. In Study 1, 1-nionth-old infants and their mothers interacted face-to-face in three types of imperfect contingent interactions: Normal, Non-Contingent and Imitation. One-month-old infants did not discriminate these conditions. In Study 2, 3-month-old infants were tested as in Study 1. At 3 months of age, infants gazed reliably longer in the Imitation condition and smiled reliably more in the Normal than in the Non-Contingent and Imitation interactions. These findings suggest a developmental transition in the sensitivity to social contingencies between 1 and 3 months of age. The relationship between the developing sensitivity to social contingencies and social cognition is discussed.
C1 Max Planck Inst Human Cognit & Brain Sci, Neurocognit & Dev, Leipzig, Germany.
Max Plank Inst Evolutionary Anthropol, Cultural Ontogeny, Leipzig, Germany.
Max Plank Inst Evolutionary Anthropol, Dev & Comparat Psychol, Leipzig, Germany.
Univ Leipzig, Ctr Adv Studies Neurocognit & Dev, D-7010 Leipzig, Germany.
RP Striano, T (reprint author), Max Planck Inst Human Cognit & Brain Sci, Neurocognit & Dev, Stephanstr 1A, Leipzig, Germany.
EM striano@cbs.mpg.de
RI Stahl, Daniel/B-9713-2011
OI Stahl, Daniel/0000-0001-7987-6619
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NR 41
TC 17
Z9 17
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 1363-755X
J9 DEVELOPMENTAL SCI
JI Dev. Sci.
PD NOV
PY 2005
VL 8
IS 6
BP 509
EP 518
DI 10.1111/j.1467-7687.2005.00442.x
PG 10
WC Psychology, Developmental; Psychology, Experimental
SC Psychology
GA 982IV
UT WOS:000233152200010
PM 16246242
ER
PT J
AU Farrant, A
Morris, RG
Russell, T
Elwes, R
Akanuma, N
Alarcon, G
Koutroumanis, M
AF Farrant, A
Morris, RG
Russell, T
Elwes, R
Akanuma, N
Alarcon, G
Koutroumanis, M
TI Social cognition in frontal lobe epilepsy
SO EPILEPSY & BEHAVIOR
LA English
DT Article
DE frontal lobe epilepsy; social cognition; theory of mind; facial emotion
recognition; neuropsychology; humor
ID VARIANT FRONTOTEMPORAL DEMENTIA; HIGH-FUNCTIONING AUTISM;
ASPERGER-SYNDROME; NEUROPSYCHOLOGICAL CHARACTERISTICS; STORY
COMPREHENSION; MIND IMPAIRMENTS; NORMAL ADULTS; LESIONS; RECOGNITION;
CHILDREN
AB This study investigated the social cognitive functioning of patients with frontal lobe epilepsy (FLE), using a range of procedures that have shown impairments in patients following focal prefrontal brain lesions. Fourteen participants with FLE were compared with 14 healthy controls on story tests of theory of mind (ToM), faux pas appreciation, mental and physical state cartoon humor appreciation, facial emotional recognition, and the ability to perceive eye gaze expression. They were not impaired on story tests of ToM and showed only a trend toward impairment on a test of faux pas appreciation. They were impaired on humor appreciation, with both mental and physical state cartoons, and on their recognition of facial emotion and perception of eye gaze expression. Hence the patients with FLE exhibited impairments on tests of social cognition following a distinct pattern, with relatively preserved ToM, but impaired humor appreciation and ability to detect emotional expression. (c) 2005 Elsevier Inc. All rights reserved.
C1 Inst Psychiat, Dept Psychol, London SE5 8AF, England.
Inst Psychiat, Neuropsychol Unit, London SE5 8AF, England.
Macquarie Univ, Macquarie Ctr Cognit Sci, Sydney, NSW 2109, Australia.
Macquarie Univ, Neurosci Inst Schizophrenia & Allied Disorders, Sydney, NSW 2109, Australia.
Kings Coll London, Dept Neurosci, Guys Kings & St Thomas Sch Med, London WC2R 2LS, England.
Kings Coll Hosp London, Dept Clin Neurophysiol, London, England.
St Thomas Hosp, Dept Clin Neurophysiol & Epilepsies, London, England.
RP Morris, RG (reprint author), Inst Psychiat, Dept Psychol, De Crespigny Pk, London SE5 8AF, England.
EM spjtrgm@iop.kcl.ac.uk
RI Alarcon, Gonzalo/C-4084-2013
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NR 55
TC 35
Z9 38
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 1525-5050
J9 EPILEPSY BEHAV
JI Epilepsy Behav.
PD NOV
PY 2005
VL 7
IS 3
BP 506
EP 516
DI 10.1016/j.yebeh.2005.07.018
PG 11
WC Behavioral Sciences; Clinical Neurology; Psychiatry
SC Behavioral Sciences; Neurosciences & Neurology; Psychiatry
GA 983GX
UT WOS:000233220600023
PM 16165399
ER
PT J
AU Lehmkuhl, G
AF Lehmkuhl, G
TI How specific are neuropsychological functions in autism?
SO FORTSCHRITTE DER NEUROLOGIE PSYCHIATRIE
LA German
DT Editorial Material
ID SPECTRUM DISORDERS; PSYCHIATRIC CONTROL; MIND; CHILDREN
C1 Univ Cologne, Klin & Poliklin Psychiat & Psychotherapie Kindes, D-50931 Cologne, Germany.
RP Lehmkuhl, G (reprint author), Univ Cologne, Klin & Poliklin Psychiat & Psychotherapie Kindes, Robert Koch Str 10, D-50931 Cologne, Germany.
EM Gerd.Lehmkuhl@uk-koeln.de
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POUSTKA F, 1998, AUTISM PERVASIVE DEV, P130
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NR 19
TC 1
Z9 1
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0720-4299
J9 FORTSCHR NEUROL PSYC
JI Forschritte Neurol. Psychiatr.
PD NOV
PY 2005
VL 73
IS 11
BP 651
EP 653
DI 10.1055/s-2005-870993
PG 5
WC Clinical Neurology; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA 986LH
UT WOS:000233450600001
PM 16283608
ER
PT J
AU Remschmidt, H
Kamp-Becker, I
AF Remschmidt, H
Kamp-Becker, I
TI Neuropsychology of autistic disorders
SO FORTSCHRITTE DER NEUROLOGIE PSYCHIATRIE
LA German
DT Article
ID HIGH-FUNCTIONING AUTISM; ASPERGERS SYNDROME; DEVELOPMENTAL DISORDERS;
CENTRAL COHERENCE; CHILDS THEORY; NORMAL ADULTS; MIND; BRAIN; TASK;
COMMUNICATION
AB Autistic disorders are pervasive developmental disorders, which are characterised by social, communicative and stereotyped, repetitive behaviour patterns. The onset of these disorders is in early childhood and they are most likely of biological origin. A review of neuropsychological questions and results is presented. Special features are found with regard to intelligence, attention, memory, speech, executive functions, theory of mind and central coherence. The different neuropsychological features are explained in terms of an integrated model which takes into account the elementary functions, systems of functioning and the underlying theoretical concepts. Autistic disorders can be understood as an integration deficit of these different functions.
C1 Univ Marburg, Klin Kinder & Jugendpsychiat & Psychotherapie, D-35039 Marburg, Germany.
RP Remschmidt, H (reprint author), Univ Marburg, Klin Kinder & Jugendpsychiat & Psychotherapie, Hans Sachs Str 4-6, D-35039 Marburg, Germany.
EM remschm@med.uni-marburg.de
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NR 73
TC 4
Z9 4
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0720-4299
J9 FORTSCHR NEUROL PSYC
JI Forschritte Neurol. Psychiatr.
PD NOV
PY 2005
VL 73
IS 11
BP 654
EP +
DI 10.1055/s-2004-830306
PG 16
WC Clinical Neurology; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA 986LH
UT WOS:000233450600002
PM 16283609
ER
PT J
AU Ptok, M
AF Ptok, M
TI Pragmatic language impairment in children
SO HNO
LA German
DT Article
DE pragmatic language impairment; specific language impairment; children;
therapeutic interventions; autism
ID COMMUNICATION CHECKLIST CCC; NONVERBAL-COMMUNICATION; AUTISTIC
SYMPTOMATOLOGY; EXECUTIVE DYSFUNCTION; EMOTIONAL EXPRESSIONS;
ASPERGER-SYNDROME; DISORDER; INTERVENTION; PRESCHOOLERS; INDIVIDUALS
AB When a child's language development does not follow the normal developmental course for no known reasons specific language impairment (SLI) is diagnosed. In contrast, pragmatic language impairment (PLI) refers to children who experience significant difficulties with the use of language. Clinical accounts of PLI have suggested that unlike children with more typical SLI, children with PLI have adequate syntax and phonology and are often verbally fluent. However, they may exhibit a range of linguistic and communicative deficits such as comprehension deficits for connected speech, conversational inadequacies, poor turn-taking, atypical word choices, literal interpretation of figurative language, and poor topic maintenance. There also may be fundamental deficits in social cognition, such as appreciating the thoughts and feelings of others. PLI may be found in SLI children, children with learning disabilities, autism and traumatic brain injuries. Here we review aspects of pragmatic communication skills, the development of emotion recognition, and diagnostic and therapeutic procedures. Otolaryngologists have to be aware of PLI in case children with communication problems are referred to them. This may enable a timely diagnosis and early intervention.
C1 MHH, Klin & Poliklin Phoniatrie & Padaudiol, D-30625 Hannover, Germany.
RP Ptok, M (reprint author), MHH, Klin & Poliklin Phoniatrie & Padaudiol, Carl Neuberg Str 1, D-30625 Hannover, Germany.
EM ptok.martin@mh-hannover.de
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NR 53
TC 2
Z9 2
PU SPRINGER
PI NEW YORK
PA 233 SPRING STREET, NEW YORK, NY 10013 USA
SN 0017-6192
J9 HNO
JI HNO
PD NOV
PY 2005
VL 53
IS 11
BP 978
EP 982
DI 10.1007/s00106-005-1267-5
PG 5
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 987ZC
UT WOS:000233555500010
PM 15909145
ER
PT J
AU Pares, N
Masri, P
van Wolferen, G
Creed, C
AF Pares, N
Masri, P
van Wolferen, G
Creed, C
TI Achieving dialogue with children with severe autism in an adaptive
multisensory interaction: The "MEDIATE" project
SO IEEE TRANSACTIONS ON VISUALIZATION AND COMPUTER GRAPHICS
LA English
DT Article
DE artificial; augmented; and virtual realities; assistive technologies for
persons with disabilities; interaction styles; psychology; metadata
ID VIRTUAL-REALITY; DISORDERS
AB This paper presents an adaptive physical environment that allows children with severe autism to successfully interact with multimodal stimuli, giving them a sense of control of the interaction and, hence, providing them with a sense of agency. This has been an extremely important effort for two main reasons: 1) This user group cannot be typified, hence making the design of an interactive system to fit all the spectrum of individuals a very complex task; 2) each individual PAS ( Person on the Autistic Spectrum) user must be able to develop himself within the environment according to his own capacities and potentiality. Qualitative evaluation by psychologists shows very good results and sketches an encouraging future for research on these environments.
C1 Univ Pompeu Fabra, Audiovisual Inst, Expt Interact Commun Grp, Barcelona 08003, Spain.
Univ Portsmouth, Sch Art Design & Media, Respons Environm Ctr, Portsmouth PO1 2DJ, Hants, England.
HKU, Fac Kunst Media & Technol, NL-1200 CL Hilversum, Netherlands.
RP Pares, N (reprint author), Univ Pompeu Fabra, Audiovisual Inst, Expt Interact Commun Grp, Pg Circumvallacio,8, Barcelona 08003, Spain.
EM npares@iua.upf.es; paulmasri.mediate@worldwithoutwalls.co.uk;
gerard.vanwolferen@kmt.hku.nl; chris.creed@port.ac.uk
CR ALCANTUD F, 2002, P COMP HELP PEOPL SP
DAUTENHAHN K, P WORKSH ROB VIRT IN
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NR 23
TC 6
Z9 6
PU IEEE COMPUTER SOC
PI LOS ALAMITOS
PA 10662 LOS VAQUEROS CIRCLE, PO BOX 3014, LOS ALAMITOS, CA 90720-1314 USA
SN 1077-2626
J9 IEEE T VIS COMPUT GR
JI IEEE Trans. Vis. Comput. Graph.
PD NOV-DEC
PY 2005
VL 11
IS 6
BP 734
EP 742
DI 10.1109/TVCG.2005.88
PG 9
WC Computer Science, Software Engineering
SC Computer Science
GA 962VN
UT WOS:000231761200013
PM 16270865
ER
PT J
AU Lew, AR
AF Lew, AR
TI Multicoloured mayhem: Parenting the many shades of adolescents and
children with autism, Asperger syndrome and AD/HD
SO INFANT AND CHILD DEVELOPMENT
LA English
DT Book Review
C1 Univ Lancaster, Lancaster LA1 4YW, England.
RP Lew, AR (reprint author), Univ Lancaster, Lancaster LA1 4YW, England.
CR JACKSON J, 2004, MULTICOLOURED MAYHEM
NR 1
TC 0
Z9 0
PU JOHN WILEY & SONS LTD
PI CHICHESTER
PA THE ATRIUM, SOUTHERN GATE, CHICHESTER PO19 8SQ, W SUSSEX, ENGLAND
SN 1522-7227
J9 INFANT CHILD DEV
JI Infant Child Dev.
PD NOV
PY 2005
VL 14
IS 4
BP 429
EP 429
DI 10.1002/icd.373
PG 1
WC Psychology, Developmental
SC Psychology
GA 986AC
UT WOS:000233419700007
ER
PT J
AU Brandes, J
AF Brandes, J
TI Everybody is different: A book for young people who have brothers or
sisters with autism
SO INTERVENTION IN SCHOOL AND CLINIC
LA English
DT Book Review
CR BLEACH F, 2002, EVERYBODY DIFFERENT
NR 1
TC 0
Z9 0
PU PRO-ED INC
PI AUSTIN
PA 8700 SHOAL CREEK BLVD, AUSTIN, TX 78757-6897 USA
SN 1053-4512
J9 INTERV SCH CLIN
JI Interv. Sch. Clin.
PD NOV
PY 2005
VL 41
IS 2
BP 120
EP 120
PG 1
WC Education, Special
SC Education & Educational Research
GA 984EA
UT WOS:000233284100010
ER
PT J
AU Brandes, J
AF Brandes, J
TI Challenging behavior and autism: Making sense - Making progress: A guide
to preventing and managing challenging behavior for parents and teachers
SO INTERVENTION IN SCHOOL AND CLINIC
LA English
DT Book Review
CR WHITAKER P, 2002, CHALLENGING BEHAVIOR
NR 1
TC 0
Z9 0
PU PRO-ED INC
PI AUSTIN
PA 8700 SHOAL CREEK BLVD, AUSTIN, TX 78757-6897 USA
SN 1053-4512
J9 INTERV SCH CLIN
JI Interv. Sch. Clin.
PD NOV
PY 2005
VL 41
IS 2
BP 121
EP 122
PG 2
WC Education, Special
SC Education & Educational Research
GA 984EA
UT WOS:000233284100016
ER
PT J
AU Connors, SL
Crowell, DE
Eberhart, CG
Copeland, J
Newschaffer, CJ
Spence, SJ
Zimmerman, AW
AF Connors, SL
Crowell, DE
Eberhart, CG
Copeland, J
Newschaffer, CJ
Spence, SJ
Zimmerman, AW
TI beta(2)-adrenergic receptor activation and genetic polymorphisms in
autism: Data from dizygotic twins
SO JOURNAL OF CHILD NEUROLOGY
LA English
DT Article
ID DIAGNOSTIC OBSERVATION SCHEDULE; GROWTH-FACTOR-I; SEROTONIN TRANSPORTER;
DEVELOPING BRAIN; PRETERM LABOR; DISORDER; TERBUTALINE; RAT; EXPRESSION;
CHILDREN
AB Gestational and genetic factors can contribute to autism during infancy and early childhood through their effects on fetal brain development. Previous twin studies have shown strong genetic components for the development of autism, a disorder that can have multiple causes. We investigated the effects of prenatal overstimulation of the beta(2)-adrenergic receptor in dizygotic twins who were exposed to terbutaline, a selective beta(2)-adrenergic receptor agonist used to treat premature labor, as a gestational factor. As a possible genetic mechanism, we studied two beta(2)-adrenergic receptor polymorphisms in twins from whom DNA was available: glycine substitution at codon 16 (16G) and glutamic acid substitution at codon 27 (27E), which show diminished desensitization in vivo compared with the wild-type receptor. Continuous terbutaline exposure for 2 weeks or longer was associated with increased concordance for autism spectrum disorders in dizygotic twins (relative risk = 2.0), with a further increase in the risk for male twins with no other affected siblings (relative risk = 4.4). A significant association was found between the presence of 16G and 27E polymorphisms in autistic patients compared with population controls (P = .006). Prenatal overstimulation of the beta(2)-adrenergic receptor by terbutaline or by increased signaling of genetic polymorphisms of the beta(2)-adrenergic receptor that have diminished desensitization can affect cellular responses and developmental programs in the fetal brain, leading to autism.
C1 Kennedy Krieger Inst, Dept Neurol & Dev Med, Baltimore, MD 21205 USA.
Johns Hopkins Univ, Sch Med, Dept Pathol, Baltimore, MD USA.
Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA.
Univ Calif Los Angeles, David Geffen Sch Med, Dept Psychiat, Los Angeles, CA USA.
Univ Calif Los Angeles, David Geffen Sch Med, Dept Pediat, Los Angeles, CA USA.
RP Zimmerman, AW (reprint author), Kennedy Krieger Inst, Dept Neurol & Dev Med, 707 N Broadway, Baltimore, MD 21205 USA.
EM zimmerman@kennedykrieger.org
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NR 75
TC 39
Z9 40
PU B C DECKER INC
PI HAMILTON
PA 20 HUGHSON ST SOUTH, PO BOX 620, L C D 1, HAMILTON, ONTARIO L8N 3K7,
CANADA
SN 0883-0738
J9 J CHILD NEUROL
JI J. Child Neurol.
PD NOV
PY 2005
VL 20
IS 11
BP 876
EP 884
DI 10.1177/08830738050200110401
PG 9
WC Clinical Neurology; Pediatrics
SC Neurosciences & Neurology; Pediatrics
GA 004BT
UT WOS:000234727700004
PM 16417856
ER
PT J
AU Sofronoff, K
Attwood, T
Hinton, S
AF Sofronoff, K
Attwood, T
Hinton, S
TI A randomised controlled trial of a CBT intervention for anxiety in
children with Asperger syndrome
SO JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY
LA English
DT Article
DE Asperger syndrome; anxiety; CBT; parent involvement
ID COGNITIVE-BEHAVIORAL TREATMENT; CHILDHOOD ANXIETY; ADOLESCENTS;
DISORDERS; AUTISM
AB Background: The aim of the study was to evaluate the effectiveness of a brief CBT intervention for anxiety with children diagnosed with Asperger syndrome (AS). A second interest was to evaluate whether more intensive parent involvement would increase the child's ability to manage anxiety outside of the clinic setting. Methods: Seventy-one children aged ten to twelve years were recruited to participate in the anxiety programme. All children were diagnosed with AS and the presence of anxiety symptoms was accepted on parent report via brief interview. Children were randomly assigned to one of three conditions: intervention for child only, intervention for child and parent, wait-list control. Results: The two intervention groups demonstrated significant decreases in parent-reported anxiety symptoms at follow-up and a significant increase in the child's ability to generate positive strategies in an anxiety-provoking situation. There were a number of significant differences between the two interventions to suggest parent involvement as beneficial. Conclusions: The sample of children with AS in this study presented with a profile of anxiety similar to a sample of clinically diagnosed anxious children. The intervention was endorsed by parents as a useful programme for children diagnosed with Asperger syndrome and exhibiting anxiety symptoms, and active parent involvement enhanced the usefulness of the programme. Limitations of the study and future research are discussed.
C1 Univ Queensland, Sch Psychol, Brisbane, Qld, Australia.
RP Sofronoff, K (reprint author), Univ Queensland, Sch Psychol, Brisbane, Qld, Australia.
EM kate@psy.uq.edu.au
CR ATTWOOD T, IN PRESS AUSTR J EAR
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NR 32
TC 123
Z9 125
PU BLACKWELL PUBLISHING
PI OXFORD
PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND
SN 0021-9630
J9 J CHILD PSYCHOL PSYC
JI J. Child Psychol. Psychiatry
PD NOV
PY 2005
VL 46
IS 11
BP 1152
EP 1160
DI 10.1111/j.1469-7610.2005.00411.x
PG 9
WC Psychology, Developmental; Psychiatry; Psychology
SC Psychology; Psychiatry
GA 975JR
UT WOS:000232658700003
PM 16238662
ER
PT J
AU Van Strien, JW
Lagers-Van Haselen, GC
Van Hagen, JM
De Coo, IFM
Frens, MA
Van der Geest, JN
AF Van Strien, JW
Lagers-Van Haselen, GC
Van Hagen, JM
De Coo, IFM
Frens, MA
Van der Geest, JN
TI Increased prevalences of left-handedness and left-eye sighting dominance
in individuals with Williams-Beuren syndrome
SO JOURNAL OF CLINICAL AND EXPERIMENTAL NEUROPSYCHOLOGY
LA English
DT Article
ID DOWNS-SYNDROME; GROWTH; GENETICS; CHILDREN; AUTISM; BRAIN; BIRTH; AGE
AB Handedness and eye sighting dominance were assessed in a sample of 50 individuals (25 male, 25 female; aged 5-38 years) with Williams-Beuren syndrome (WBS). The prevalences of left-handedness and left-eyedness were compared to the normative prevalences in the general population. We found significantly higher prevalences of left-handedness and left-eyedness in the WBS sample. The higher prevalences were more salient in younger than in older individuals and in male than in female individuals. We suggest that the increased prevalence of left-handedness in WBS is a consequence of a slower maturation rate, which allows deviation from a predetermined laterality pattern.
C1 Erasmus Univ, Fac Social Sci, Dept Psychol, NL-3000 DR Rotterdam, Netherlands.
Erasmus MC, Dept Neurosci, Rotterdam, Netherlands.
Vrije Univ Amsterdam, Med Ctr, Dept Clin Genet & Human Genet, NL-1081 HV Amsterdam, Netherlands.
Erasmus MC, Dept Neurol, Rotterdam, Netherlands.
RP Van Strien, JW (reprint author), Erasmus Univ, Fac Social Sci, Dept Psychol, POB 1738, NL-3000 DR Rotterdam, Netherlands.
EM vanstrien@fsw.eur.nl
RI Van Strien, Jan/A-1673-2008
OI Van Strien, Jan/0000-0002-3198-9267
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NR 30
TC 12
Z9 13
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA
SN 1380-3395
J9 J CLIN EXP NEUROPSYC
JI J. Clin. Exp. Neuropsychol.
PD NOV
PY 2005
VL 27
IS 8
BP 967
EP 976
DI 10.1080/13803390490919119
PG 10
WC Psychology, Clinical; Clinical Neurology; Psychology
SC Psychology; Neurosciences & Neurology
GA 977CJ
UT WOS:000232779700004
PM 16207621
ER
PT J
AU Hamilton, D
Sutherland, G
Iacono, T
AF Hamilton, D
Sutherland, G
Iacono, T
TI Further examination of relationships between life events and psychiatric
symptoms in adults with intellectual disability
SO JOURNAL OF INTELLECTUAL DISABILITY RESEARCH
LA English
DT Article
DE adults; DBC-A; intellectual disability; life events; life stress
ID DEVELOPMENTAL-DISABILITIES; CHILDREN; AUTISM; BEHAVIOR; CORTISOL
AB Background It has been proposed that people with intellectual disability (ID) might be similar to the general population in the way they respond to significant life events. Some preliminary findings have demonstrated that adults with ID who have experienced recent life events have an increased probability of having psychiatric problems. The aims of the present study were to determine whether previous findings can be replicated, and to examine the influence of additional diagnoses associated with ID on the strength of relationships between life event frequency and psychiatric problems.
Methods Adults with ID (n = 624), living either in staffed community accommodation or in family or foster homes, were assessed on the Developmental Behaviour Checklist for Adults (DBC-A) and a 37-item life events checklist. Carers who knew the person well acted as proxy informants.
Results People living in staffed accommodation experienced more life events than people living with natural or foster families. Life event frequency predicted DBC-A total score, five of six sub-scale scores, and caseness status, after significant demographic factors were taken into account. However, the strength of correlations between life event frequency and DBC-A total score varied among sub-groups identified by type of developmental disability and level of ID.
Conclusions Weak but significant associations between emotional and behavioural problems and life events experienced by adults with ID were demonstrated, but it was also shown that the strength of such associations varies among sub-groups of this heterogeneous population. Future research needs to take account of the circumstances surrounding the life changes, the period of time over which changes might have taken place, and the meaning that the person might attach to the changes. Research into the causal relationship between exposure to life events and the onset of psychiatric problems is also warranted.
C1 Monash Univ, Ctr Dev Diabil Hlth Victoria, Melbourne, Vic 3004, Australia.
RP Hamilton, D (reprint author), Deakin Univ, Sch Hlth & Social Dev, 221 Burwood Highway, Burwood, Vic 3125, Australia.
EM david.hamilton@deakin.edu.au
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NR 16
TC 23
Z9 23
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0964-2633
J9 J INTELL DISABIL RES
JI J. Intell. Disabil. Res.
PD NOV
PY 2005
VL 49
BP 839
EP 844
DI 10.1111/j.1365-2788.2005.00761.x
PN 11
PG 6
WC Education, Special; Genetics & Heredity; Clinical Neurology; Psychiatry;
Rehabilitation
SC Education & Educational Research; Genetics & Heredity; Neurosciences &
Neurology; Psychiatry; Rehabilitation
GA 971MW
UT WOS:000232389400004
PM 16207281
ER
PT J
AU Pickett, J
London, E
AF Pickett, J
London, E
TI The neuropathology of autism: A review
SO JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
LA English
DT Review
DE Asperger; autism; brain; neurodevelopment; neuropathology; pervasive
developmental disorder (PDD)
ID MENTAL-RETARDATION; MAJOR DEPRESSION; BRAIN; DISORDER; GENE; EXPRESSION;
REELIN; AMYGDALA; COMPLEX; SUSCEPTIBILITY
AB Presented is a review of recent progress in the understanding of autism based on investigations of donated human brain tissue. Autism is a pervasive developmental disorder by the American Psychiatric Association's Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) criteria, manifesting by age 3 and characterized by impairments in social interaction and communication, as well as restricted, repetitive, stereotyped patterns of behavior. Based on reported neuropathologic findings, these characteristic behaviors are clinical manifestations of both pre- and postnatal alterations. This review summarizes the current data obtained from postmortem brain studies in the areas of stereology, neurotransmitter systems/synaptic processes, molecular mechanisms, and neuroimmunology. In addition, we discuss current research strategies designed to facilitate translational research and maximize the yield of precious resources (e.g. the Autism Tissue Program), highlight barriers to research, and consider future trends.
C1 Autism Tissue Program, Princeton, NJ 08540 USA.
Natl Alliance Autism Res, Princeton, NJ USA.
RP Pickett, J (reprint author), Autism Tissue Program, 99 Wall St,Res Pk, Princeton, NJ 08540 USA.
EM atp@brainbank.org
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NR 70
TC 70
Z9 73
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3261 USA
SN 0022-3069
J9 J NEUROPATH EXP NEUR
JI J. Neuropathol. Exp. Neurol.
PD NOV
PY 2005
VL 64
IS 11
BP 925
EP 935
DI 10.1097/01.jnen.0000186921.42592.6c
PG 11
WC Clinical Neurology; Neurosciences; Pathology
SC Neurosciences & Neurology; Pathology
GA 983RN
UT WOS:000233249900001
PM 16254487
ER
PT J
AU Percaccio, CR
Engineer, ND
Pruette, AL
Pandya, PK
Moucha, R
Rathbun, DL
Kilgard, MP
AF Percaccio, CR
Engineer, ND
Pruette, AL
Pandya, PK
Moucha, R
Rathbun, DL
Kilgard, MP
TI Environmental enrichment increases paired-pulse depression in rat
auditory cortex
SO JOURNAL OF NEUROPHYSIOLOGY
LA English
DT Article
ID CAT VISUAL-CORTEX; EVOKED-RESPONSES; SCHIZOPHRENIC-PATIENTS; TEMPORAL
INFORMATION; INDUCED MICROGYRIA; ANIMAL-MODEL; PLASTICITY; CHILDREN;
NEURONS; DEFICITS
AB Temporal features are important for the identification of natural sounds. Earlier studies have shown that cortical processing of temporal information can be altered by long-term experience with modulated sounds. In a previous study, we observed that environmental enrichment dramatically increased the response of cortical neurons to single tone and noise burst stimuli in both awake and anesthetized rats. Here, we evaluate how enrichment influences temporal information processing in the auditory cortex. We recorded responses to repeated tones and noise bursts in awake rats using epidural evoked potentials and in anesthetized rats using microelectrodes. Enrichment increased the response of cortical neurons to stimuli presented at slow rates and decreased the response to stimuli presented at fast rates relative to controls. Our observation that enrichment substantially increased response strength and forward masking is consistent with earlier reports that long-term potentiation of cortical synapses is associated with increased paired-pulse depression. Enrichment also increased response synchronization at slow rates and decreased synchronization at fast rates. Paired-pulse depression increased within days of environmental enrichment and was restored to normal levels after return to standard housing conditions. These results are relevant to several clinical disorders characterized by abnormal gating of sensory information, including autism, schizophrenia, and dyslexia.
C1 Univ Texas, Sch Behav & Brain Sci, Neurosci Program, Richardson, TX 75083 USA.
RP Kilgard, MP (reprint author), Univ Texas, Sch Behav & Brain Sci, Neurosci Program, GR 41, Richardson, TX 75083 USA.
EM kilgard@utdallas.edu
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NR 54
TC 29
Z9 30
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0022-3077
J9 J NEUROPHYSIOL
JI J. Neurophysiol.
PD NOV
PY 2005
VL 94
IS 5
BP 3590
EP 3600
DI 10.1152/jn.00433.2005
PG 11
WC Neurosciences; Physiology
SC Neurosciences & Neurology; Physiology
GA 973NF
UT WOS:000232528900053
PM 16093336
ER
PT J
AU Holtmann, M
Bolte, S
Poustka, F
AF Holtmann, M
Bolte, S
Poustka, F
TI ADHD, Asperger syndrome, and high-functioning autism
SO JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
LA English
DT Letter
ID DISORDER
C1 Univ Frankfurt, Dept Child & Adolescent Psychiat & Psychotherapy, D-6000 Frankfurt, Germany.
RP Holtmann, M (reprint author), Univ Frankfurt, Dept Child & Adolescent Psychiat & Psychotherapy, D-6000 Frankfurt, Germany.
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
Bolte S, 1999, PSYCHOPATHOLOGY, V32, P94
Fitzgerald M, 2005, J AM ACAD CHILD PSY, V44, P210, DOI 10.1097/01.chi.0000152633.75570.90
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Goldstein S, 2004, J AUTISM DEV DISORD, V34, P329, DOI 10.1023/B:JADD.0000029554.46570.68
NR 5
TC 20
Z9 20
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3261 USA
SN 0890-8567
J9 J AM ACAD CHILD PSY
JI J. Am. Acad. Child Adolesc. Psychiatr.
PD NOV
PY 2005
VL 44
IS 11
BP 1101
EP 1101
DI 10.1097/01.chi.0000177322.57931.2a
PG 1
WC Psychology, Developmental; Pediatrics; Psychiatry
SC Psychology; Pediatrics; Psychiatry
GA 976IL
UT WOS:000232726800001
PM 16239855
ER
PT J
AU Troost, PW
Lahuis, BE
Steenhuis, MP
Ketelaars, CEJ
Buitelaar, JK
Van Engeland, H
Scahill, L
Minderaa, RB
Hoekstra, PJ
AF Troost, PW
Lahuis, BE
Steenhuis, MP
Ketelaars, CEJ
Buitelaar, JK
Van Engeland, H
Scahill, L
Minderaa, RB
Hoekstra, PJ
TI Long-term effects of risperidone in children with autism spectrum
disorders: A placebo discontinuation study
SO JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
LA English
DT Article
DE risperidone; pervasive developmental disorder; psychopharmacology;
tantrums
ID PERVASIVE DEVELOPMENTAL DISORDERS; DISRUPTIVE BEHAVIOR DISORDERS;
ATYPICAL ANTIPSYCHOTICS; OPEN-LABEL; ADOLESCENTS; TOLERABILITY;
INDIVIDUALS; EFFICACY; WEIGHT; SAFETY
AB Objective: The short-term benefit of risperidone in ameliorating severe disruptive behavior in pediatric patients with autism spectrum disorders is well established; however, only one placebo-controlled, long-term study of efficacy is available. Method: Thirty-six children with an autism spectrum disorder (5-17 years old) accompanied by severe tantrums, aggression, or self-injurious behavior, started 8-week open-label treatment with risperidone. Responders (n = 26) continued treatment for another 16 weeks, followed by a double-blind discontinuation (n = 24; two patients discontinued treatment because of weight gain) consisting of either 3 weeks of taper and 5 weeks of placebo only or continuing use of risperidone. Relapse was defined as a significant deterioration of symptoms based on clinical judgment and a parent questionnaire. Results: Risperidone was superior to placebo in preventing relapse: this occurred in 3 of 12 patients continuing on risperidone versus 8 of 12 who switched to placebo (p = .049). Weight gain, increased appetite, anxiety, and fatigue were the most frequently reported side effects. Conclusions: This study indicates the effectiveness of risperidone during a period of several months, reducing disruptive behavior in about half of the children with autism spectrum disorders. The results provide a rationale for the continuing use of risperidone beyond 6 months, although considerable weight gain can limit the use of this agent.
C1 Univ Groningen, Med Ctr, Dept Psychiat, Groningen, Netherlands.
Univ Utrecht, Ctr Med, Dept Child Psychiat, Utrecht, Netherlands.
Univ Utrecht, Ctr Med, Rudolf Magnus Inst Neurosci, Utrecht, Netherlands.
Univ Nijmegen, Med Ctr, Dept Psychiat, Nijmegen, Netherlands.
Yale Univ, Ctr Child Study, New Haven, CT 06520 USA.
RP Troost, PW (reprint author), Child & Adolescent Psychiat Ctr, Hanzepl 1, NL-9713 GZ Groningen, Netherlands.
EM p.troost@accare.nl
RI Buitelaar, Jan/E-4584-2012; Hoekstra, Pieter/O-4396-2014
OI Buitelaar, Jan/0000-0001-8288-7757;
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NR 30
TC 75
Z9 75
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3261 USA
SN 0890-8567
J9 J AM ACAD CHILD PSY
JI J. Am. Acad. Child Adolesc. Psychiatr.
PD NOV
PY 2005
VL 44
IS 11
BP 1137
EP 1144
DI 10.1097/01.chi.0000177055.11229.76
PG 8
WC Psychology, Developmental; Pediatrics; Psychiatry
SC Psychology; Pediatrics; Psychiatry
GA 976IL
UT WOS:000232726800009
PM 16239862
ER
PT J
AU Shirley, DS
AF Shirley, DS
TI Challenges to autism research
SO JOURNAL OF THE ROYAL SOCIETY OF MEDICINE
LA English
DT Editorial Material
C1 Chair Shirley Fdn, Oxford RG9 2NA, England.
RP Shirley, DS (reprint author), Chair Shirley Fdn, Oxford RG9 2NA, England.
EM steve@steveshirley.com
CR EGAN K, IN PRESS AUTISM STAT
NR 1
TC 1
Z9 1
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0141-0768
EI 1758-1095
J9 J ROY SOC MED
JI J. R. Soc. Med.
PD NOV
PY 2005
VL 98
IS 11
BP 523
EP 525
DI 10.1258/jrsm.98.11.523
PG 3
WC Medicine, General & Internal
SC General & Internal Medicine
GA 985VS
UT WOS:000233407400017
ER
PT J
AU Weiskopf, DA
AF Weiskopf, DA
TI Mental mirroring as the origin of attributions
SO MIND & LANGUAGE
LA English
DT Article
ID PERSPECTIVE-TAKING; VISUAL-PERCEPTION; WORKING-MEMORY; AUTISM; IMAGERY;
CHILDREN; MIND; DISSOCIATION; IMAGINATION; SIMULATION
AB A 'Radical Simulationist' account of how folk psychology functions has been developed by Robert Gordon. I argue that Radical Simulationism is false. In its simplest form it is not sufficient to explain our attribution of mental states to subjects whose desires and preferences differ from our own. Modifying the theory to capture these attributions invariably generates innumerable other false attributions. Further, the theory predicts that deficits in mentalizing ought to co-occur with certain deficits in imagining perceptually-based scenarios. I present evidence suggesting that this prediction is false, and outline further possible empirical tests of the theory.
C1 Univ S Florida, Dept Philosophy, Tampa, FL 33620 USA.
RP Weiskopf, DA (reprint author), Univ S Florida, Dept Philosophy, 4202 E Fowler Ave,FAO 226, Tampa, FL 33620 USA.
EM weiskopf@luna.cas.usf.edu
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NR 53
TC 2
Z9 2
PU BLACKWELL PUBLISHING
PI OXFORD
PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND
SN 0268-1064
J9 MIND LANG
JI Mind Lang.
PD NOV
PY 2005
VL 20
IS 5
BP 495
EP 520
DI 10.1111/j.0268-1064.2005.00297.x
PG 26
WC Linguistics; Psychology, Experimental
SC Linguistics; Psychology
GA 978IJ
UT WOS:000232866500002
ER
PT J
AU D'Amelio, M
Ricci, I
Sacco, R
Liu, X
D'Agruma, L
Muscarella, LA
Guarnieri, V
Militerni, R
Bravaccio, C
Elia, M
Schneider, C
Melmed, R
Trillo, S
Pascucci, T
Puglisi-Allegra, S
Reichelt, KL
Macciardi, F
Holden, JJA
Persico, AM
AF D'Amelio, M
Ricci, I
Sacco, R
Liu, X
D'Agruma, L
Muscarella, LA
Guarnieri, V
Militerni, R
Bravaccio, C
Elia, M
Schneider, C
Melmed, R
Trillo, S
Pascucci, T
Puglisi-Allegra, S
Reichelt, KL
Macciardi, F
Holden, JJA
Persico, AM
TI Paraoxonase gene variants are associated with autism in North America,
but not in Italy: possible regional specificity in gene-environment
interactions
SO MOLECULAR PSYCHIATRY
LA English
DT Article
DE APOE; autistic disorder; chlorpyrifos; diazinon; organophosphates;
Reelin
ID HUMAN SERUM PARAOXONASE; FAMILY-BASED TESTS; DEVELOPMENTAL EXPOSURE;
SEROTONIN TRANSPORTER; REELIN GENE; PLATELET SEROTONIN; CRITICAL
PERIODS; PON1 GENE; CHILDREN; CHLORPYRIFOS
AB Organophosphates (OPs) are routinely used as pesticides in agriculture and as insecticides within the household. Our prior work on Reelin and APOE delineated a gene - environment interactive model of autism pathogenesis, whereby genetically vulnerable individuals prenatally exposed to OPs during critical periods in neurodevelopment could undergo altered neuronal migration, resulting in an autistic syndrome. Since household use of OPs is far greater in the USA than in Italy, this model was predicted to hold validity in North America, but not in Europe. Here, we indirectly test this hypothesis by assessing linkage/association between autism and variants of the paraoxonase gene (PON1) encoding paraoxonase, the enzyme responsible for OP detoxification. Three functional single nucleotide polymorphisms, PON1 C - 108T, L55M, and Q192R, were assessed in 177 Italian and 107 Caucasian-American complete trios with primary autistic probands. As predicted, Caucasian-American and not Italian families display a significant association between autism and PON1 variants less active in vitro on the OP diazinon (R192), according to case - control contrasts (Q192R: chi(2) = 6.33, 1 df, P<0.025), transmission/disequilibrium tests (Q192R: TDT chi(2) = 5.26, 1 df, P<0.025), familybased association tests (Q192R and L55M: FBAT Z = 2.291 and 2.435 respectively, P<0.025), and haplotype-based association tests (L55/R192: HBAT Z = 2.430, P<0.025). These results are consistent with our model and provide further support for the hypothesis that concurrent genetic vulnerability and environmental OP exposure may possibly contribute to autism pathogenesis in a sizable subgroup of North American individuals.
C1 Univ Campus Biomedico, Lab Mol Psychiat & Neurogenet, I-00155 Rome, Italy.
Queens Univ, Dept Psychiat, Kingston, ON K7L 3N6, Canada.
Queens Univ, Dept Physiol, Kingston, ON K7L 3N6, Canada.
IRCCS, Med Genet Serv, San Giovanni Rotondo, Italy.
Univ Naples Federico II, Dept Child Neuropsychiat, Naples, Italy.
IRCCS Oasi Maria SS, Neurol Serv, Troina, EN, Italy.
Ctr Autism Res & Educ, Phoenix, AZ USA.
SW Autism Res & Resource Ctr, Phoenix, AZ USA.
Assoc Anni Verdi ONLUS, Rome, Italy.
Univ Roma La Sapienza, Dept Psychol, Rome, Italy.
Univ Oslo, Rikshosp, Dept Pediat Res, N-0027 Oslo, Norway.
Univ Toronto, Ctr Addict & Mental Hlth, Neurogenet Sect, Toronto, ON, Canada.
IRCCS, Fdn Santa Lucia, Rome, Italy.
Univ Milan, Dept Biol & Genet, Milan, Italy.
Serono Genet Inst, Dept Biostat & Genet Epidemiol, Evry, France.
Autism Res Program, Kingston, ON, Canada.
RP Persico, AM (reprint author), Univ Campus Biomedico, Lab Mol Psychiat & Neurogenet, Via Longoni 83, I-00155 Rome, Italy.
EM a.persico@unicampus.it
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NR 67
TC 59
Z9 62
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1359-4184
J9 MOL PSYCHIATR
JI Mol. Psychiatr.
PD NOV
PY 2005
VL 10
IS 11
BP 1006
EP 1016
DI 10.1038/sj.mp.4001714
PG 11
WC Biochemistry & Molecular Biology; Neurosciences; Psychiatry
SC Biochemistry & Molecular Biology; Neurosciences & Neurology; Psychiatry
GA 977WA
UT WOS:000232833000007
PM 16027737
ER
PT J
AU Francois, G
Duclos, P
Margolis, H
Lavanchi, D
Siegrist, CA
Meheus, A
Lambert, PH
Emiroglu, N
Badur, S
Van Damme, P
AF Francois, G
Duclos, P
Margolis, H
Lavanchi, D
Siegrist, CA
Meheus, A
Lambert, PH
Emiroglu, N
Badur, S
Van Damme, P
TI Vaccine safety controversies and the future of vaccination programs
SO PEDIATRIC INFECTIOUS DISEASE JOURNAL
LA English
DT Review
DE vaccine safety; scares; vaccination programs; hepatitis B; communication
strategies; international organizations; media
ID HEPATITIS-B VACCINATION; MUMPS-RUBELLA VACCINATION;
THIMEROSAL-CONTAINING VACCINES; RISK-BENEFIT PROFILE;
MULTIPLE-SCLEROSIS; ADVERSE EVENTS; CAUSAL ASSOCIATION; SYSTEMATIC
REVIEWS; GLOBAL PERSPECTIVE; NO EVIDENCE
AB In the years following the hepatitis B vaccination/multiple sclerosis controversy, a number of new issues regarding vaccine safety have been raised, in some cases leading to more debate and confusion. Against this background, an international group of experts was convened to review the current points of view concerning the use of thimerosal as a preservative and its potential risks; the suggested link between thimerosal-containing vaccines and acute lymphoblastic leukemia; the alleged association between aluminum-containing, vaccines/macrophagic myofasciitis and general systemic complaints; a possible link between vaccination and autoimmune pathology; and a hypothetical link between measles-mumps-rubella vaccination and autism. At present, there are no data to conclude that childhood vaccines, and in particular hepatitis B vaccine, pose a serious health risk or justify a change in current immunization practice. However, vaccine "scares" continue to have an international impact on immunization coverage. Creating a positive environment for immunization can be achieved by repositioning the value of vaccines and vaccination, supported by evidence-based information. The role of international organizations, the media, and the industry in the implementation of communication strategies was discussed and the impact of litigation issues on vaccination was evaluated. The Viral Hepatitis Prevention Board confirms its commitment to current recommendations for universal and risk group hepatitis B vaccination and further encourages the conduct of vaccine safety studies and the dissemination of their results.
C1 Univ Antwerp, Dept Epidemiol & Social Med, WHO Collaborating Ctr Prevent & Control Viral Hep, Viral Hepatitis Prevent Board, B-2020 Antwerp, Belgium.
WHO, HTP, V&B, VAM,Immunizat Safety Prior Project, CH-1211 Geneva, Switzerland.
Ctr Dis Control & Prevent, Natl Ctr Infect Dis, Div Viral Hepatitis, Atlanta, GA 30333 USA.
WHO, Dept Communicable Dis Surveillance & Respose, CH-1211 Geneva, Switzerland.
Univ Geneva, CMU, Ctr Vaccinol & Neonatal Immunol, CH-1211 Geneva, Switzerland.
WHO, Reg Off Europe, Communicable Dis Control Prevent & Eradicat, DK-2100 Copenhagen, Denmark.
Univ Istanbul, Dept Microbiol, Istanbul, Turkey.
RP Francois, G (reprint author), Univ Antwerp, Dept Epidemiol & Social Med, WHO Collaborating Ctr Prevent & Control Viral Hep, Viral Hepatitis Prevent Board, B-2020 Antwerp, Belgium.
EM guido.francois@ua.ac.be
RI van damme, pierre/I-4846-2013
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NR 117
TC 34
Z9 36
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3261 USA
SN 0891-3668
J9 PEDIATR INFECT DIS J
JI Pediatr. Infect. Dis. J.
PD NOV
PY 2005
VL 24
IS 11
BP 953
EP 961
DI 10.1097/01.inf.0000183853.16113.a6
PG 9
WC Immunology; Infectious Diseases; Pediatrics
SC Immunology; Infectious Diseases; Pediatrics
GA 985HP
UT WOS:000233368500002
PM 16282928
ER
PT J
AU Ming, X
Stein, TP
Brimacombe, M
Johnson, WG
Lambert, GH
Wagner, GC
AF Ming, X
Stein, TP
Brimacombe, M
Johnson, WG
Lambert, GH
Wagner, GC
TI Increased excretion of a lipid peroxidation biomarker in autism
SO PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS
LA English
DT Article
ID ANTIOXIDANT ENZYME-ACTIVITIES; INCREASED OXIDATIVE STRESS; SPECTRUM
DISORDERS; VALPROIC ACID; NITRIC-OXIDE; DNA-DAMAGE; CHILDREN;
ISOPROSTANES; MELATONIN; F-2-ISOPROSTANES
AB It is thought that autism could result from an interaction between genetic and environmental factors with oxidative stress as a potential mechanism linking the two. One genetic factor may be altered oxidative-reductive capacity. This study tested the hypothesis that children with autism have increased oxidative stress. We evaluated children with autism for the presence of two oxidative stress biomarkers. Urinary excretion of 8-hydroxy-2-deoxyguanosine (8-OHdG) and 8-isoprostane-F2 alpha (8-iso-PGF2 alpha) were determined in 33 children with autism and 29 healthy controls. 8-iso-PGF2 alpha levels were significantly higher in children with autism. The isoprostane levels in autistic subjects were variable with a bimodal distribution. The majority of autistic subjects showed a moderate increase in isoprostane levels while a smaller group of autistic children showed dramatic increases in their isoprostane levels. There was a trend of an increase in 8-OHdG levels in children with autism but it did not reach statistical significance. There was no significant correlation between the levels of the biomarkers and vitamin intake, dietary supplements, medicine, medical disorders, or history of regression. These results suggest that the lipid peroxidation biomarker is increased in this cohort of autistic children, especially in the subgroup of autistic children. (c) 2005 Elsevier Ltd. All rights reserved.
C1 Univ Med & Dent New Jersey, New Jersey Med Sch, Dept Neurosci, Newark, NJ 07103 USA.
Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Ctr Childhood Neurotoxicol & Exposure Assessment, Dept Pediat, New Brunswick, NJ USA.
Univ Med & Dent New Jersey, Sch Osteopath Med, Dept Surg, Stratford, NJ 08084 USA.
Univ Med & Dent New Jersey, New Jersey Med Sch, Dept Prevent Med & Publ Hlth, Newark, NJ 07103 USA.
Univ Med & Dent New Jersey, New Jersey Med Sch, Dept Neurol, Div Neurogenet, Newark, NJ 07103 USA.
Rutgers State Univ, Dept Psychol, Piscataway, NJ USA.
RP Ming, X (reprint author), Univ Med & Dent New Jersey, New Jersey Med Sch, Dept Neurosci, 90 Bergen St,Suite 8100, Newark, NJ 07103 USA.
EM mingxu@umdnj.edu
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NR 44
TC 96
Z9 98
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0952-3278
J9 PROSTAG LEUKOTR ESS
JI Prostaglandins Leukot. Essent. Fatty Acids
PD NOV
PY 2005
VL 73
IS 5
BP 379
EP 384
DI 10.1016/j.plefa.2005.06.002
PG 6
WC Biochemistry & Molecular Biology; Cell Biology; Endocrinology &
Metabolism
SC Biochemistry & Molecular Biology; Cell Biology; Endocrinology &
Metabolism
GA 974IU
UT WOS:000232585700008
PM 16081262
ER
PT J
AU Williams, G
Perez-Gonzalez, LA
Madeira, JM
Menendez-Suarez, S
AF Williams, G
Perez-Gonzalez, LA
Madeira, JM
Menendez-Suarez, S
TI How to teach children with autism to ask questions functionally
relevant: a systematic replication.
SO PSICOTHEMA
LA Spanish
DT Article
AB How to teach children with autism to ask questions functionally relevant: a systematic replication. This study was a systematic replication of Williams, Perez-Gonzalez, and Vogt's study aimed to teach a child with autism to ask questions. We presented to the child boxes with pleasant objects inside. We taught him to ask, "What is in the box?" to know the name of the object, "Can I see it?" to see it, and "Can I have it?" to retrieve it. The child learned to ask the first question. When he learned to ask the second question, he stopped asking the first one. Then, we analyzed whether the child would learn, under these circumstances, to ask the three questions independently. The child learned again the first question. He also learned to ask the third one. A final probe showed that the child learned the three questions as three independent repertoires. Moreover, he generalized question asking to his everyday life. Thus, these results showed that having difficulties to ask the first two questions does not affect the final acquisition of the three questions as three functionally independent skills, appropriate to each specific context. These findings are relevant for the habilitation of children with autism and children with pervasive development delays.
C1 Univ Oviedo, Fac Psicol, Oviedo 33003, Spain.
Ctr Invest Lenguaje, Oviedo, Spain.
RP Perez-Gonzalez, LA (reprint author), Univ Oviedo, Fac Psicol, Oviedo 33003, Spain.
EM laperez@uniovi.es
RI Perez-Gonzalez, Luis/L-2338-2014
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NR 10
TC 1
Z9 1
PU COLEGIO OFICIAL DE PSICOLOGOS DE ASTURIAS
PI OVIEDO
PA ILDEFONSO S. DEL RIO, 4-1 B, 33001 OVIEDO, SPAIN
SN 0214-9915
J9 PSICOTHEMA
JI Psicothema
PD NOV
PY 2005
VL 17
IS 4
BP 597
EP 600
PG 4
WC Psychology, Multidisciplinary
SC Psychology
GA 977YW
UT WOS:000232840400009
ER
PT J
AU Rapp, JT
Vollmer, TR
AF Rapp, JT
Vollmer, TR
TI Stereotypy II: a review of neurobiological interpretations and
suggestions for an integration with behavioral methods
SO RESEARCH IN DEVELOPMENTAL DISABILITIES
LA English
DT Review
DE stereotypy; clomipramine; naltrexone
ID SELF-INJURIOUS-BEHAVIOR; TERM NALTREXONE TREATMENT; MENTAL-RETARDATION;
DEVELOPMENTAL-DISABILITIES; ESTABLISHING OPERATION;
AMPHETAMINE-STEREOTYPY; CLOMIPRAMINE TREATMENT; PLASMA-CORTICOSTERONE;
AUTISTIC-CHILDREN; COPING RESPONSE
AB Stereotypy is a relatively common behavioral disorder displayed by individuals with developmental disabilities, including autism. In this paper, we review selected studies on neurobiological interpretations of stereotypy and pharmacological interventions for stereotypy. Specifically, we review studies that evaluated the effects of serotonin uptake inhibitors (e.g., clomipramine) or opioid antagonists (e.g., naltrexone) on stereotypy displayed by humans. Throughout, suggestions are made for the incorporation of behavioral methods into this area of research. (c) 2005 Elsevier Ltd. All rights reserved.
C1 Texana MHMR, Behav Treatment & Training Ctr, Richmond, TX 77469 USA.
Univ Florida, Gainesville, FL 32611 USA.
RP Rapp, JT (reprint author), Texana MHMR, Behav Treatment & Training Ctr, 1818 Collins Rd, Richmond, TX 77469 USA.
EM john.rapp@texanamhmr.com
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NR 53
TC 20
Z9 20
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0891-4222
J9 RES DEV DISABIL
JI Res. Dev. Disabil.
PD NOV-DEC
PY 2005
VL 26
IS 6
BP 548
EP 564
DI 10.1016/j.ridd.2004.11.006
PG 17
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA 994WT
UT WOS:000234062600004
PM 16303583
ER
PT J
AU Maynard, DW
AF Maynard, DW
TI Social actions, gestalt coherence, and designations of disability:
Lessons from and about autism
SO SOCIAL PROBLEMS
LA English
DT Article; Proceedings Paper
CT Meeting of the Consortium-of-Universities-of-Kyoto
CY MAR, 2004
CL Kyoto, JAPAN
SP Consortium Univ Kyoto
ID TALK-IN-INTERACTION; CHILDREN; COMPETENCE; DISCOURSE
AB This article has three main points:(1) "gestalt objects" are not just perceptual chimera, but area feature of everyday talk and social action; (2) a disability such as autism can be treated in terms of the intelligence it may gloss as comprising analyzable practices-in-interaction; and (3) the sociology of deviance and social problems can benefit from studies of the intrinsic orderliness of everyday talk and social interaction in both regular, or ordinary, and more specialized settings such as clinics. The data are two segments from a testing and diagnostic center for developmental disabilities in the United States. Each segment involves a child who is diagnosed with autism and is being administered a test that poses questions such as, "What do you do when you're hungry?" The puzzle this test presents is to account for the patterns of both standard (commonsensical) and non-standard (autistic) answering. In accounting for patterns of answering, I use ordinary conversational instances of "what do you do when x happens?" to reveal the logic required in the test, and to describe both commonsense and autistic intelligence. Interactionally, autistic answering may reverse a structural preference for gestalt or global interpretation of utterances in favor of stimulus-bound, local understandings.
C1 Univ Wisconsin, Dept Sociol, Madison, WI 53706 USA.
RP Maynard, DW (reprint author), Univ Wisconsin, Dept Sociol, Madison, WI 53706 USA.
EM maynard@ssc.wisc.edu
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NR 73
TC 12
Z9 12
PU UNIV CALIF PRESS
PI BERKELEY
PA C/O JOURNALS DIVISION, 2000 CENTER ST, STE 303, BERKELEY, CA 94704-1223
USA
SN 0037-7791
J9 SOC PROBL
JI Soc. Probl.
PD NOV
PY 2005
VL 52
IS 4
BP 499
EP 524
DI 10.1525/sp.2005.52.4.499
PG 26
WC Sociology
SC Sociology
GA 981YG
UT WOS:000233123300005
ER
PT J
AU Shaked, M
AF Shaked, M
TI The social trajectory of illness: Autism in the ultraorthodox community
in Israel
SO SOCIAL SCIENCE & MEDICINE
LA English
DT Article
DE Israel; autism; ultraorthodox; social trajectory; spiritual discourse
ID CHILDREN
AB Severe or chronic illness-related events present patients and their family members with a physically and socially changed reality. In analyzing 30 open-ended interviews of ultraorthodox Jewish Israeli mothers of children with autism, this paper addresses the general question of one childhood disorder's social trajectory and examines in particular mothers' efforts to promote their children's re-inclusion into the community. The illness narratives reveal the mothers' role as mediators between the child and the community, educating the child in religious praxis on the one hand and striving to bend social norms regarding this praxis to permit inclusion on the other. Despite these daily efforts, the ultraorthodox community challenges these children's status, and mothers turn to religious discourse to establish the status of the child with autism as an able Jewish individual. In utilizing spiritual discourse in daily activities, mothers only employ those cultural elements that advance the child's integration, thus further constructing small changes in religious themes. The findings highlight not only the mothers' role as mediators, but also their potential ability to set in motion processes of change. (c) 2005 Elsevier Ltd. All rights reserved.
C1 Hebrew Univ Jerusalem, Dept Psychol, IL-91905 Mt Scopus, Israel.
RP Shaked, M (reprint author), Hebrew Univ Jerusalem, Dept Psychol, IL-91905 Mt Scopus, Israel.
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NR 25
TC 9
Z9 9
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0277-9536
J9 SOC SCI MED
JI Soc. Sci. Med.
PD NOV
PY 2005
VL 61
IS 10
BP 2190
EP 2200
DI 10.1016/j.socscimed.2005.04.022
PG 11
WC Public, Environmental & Occupational Health; Social Sciences, Biomedical
SC Public, Environmental & Occupational Health; Biomedical Social Sciences
GA 972OW
UT WOS:000232464100011
PM 15967557
ER
PT J
AU Senju, A
Hasegawa, T
Tojo, Y
AF Senju, A
Hasegawa, T
Tojo, Y
TI Does perceived direct gaze boost detection in adults and children with
and without autism? The stare-in-the-crowd effect revisited
SO VISUAL COGNITION
LA English
DT Article
ID UPSIDE-DOWN FACES; EYE CONTACT; VISUAL-SEARCH; FACIAL EXPRESSIONS; EARLY
RECOGNITION; ASPERGER-SYNDROME; JOINT ATTENTION; PERCEPTION; BRAIN;
INDIVIDUALS
AB This study extended that of von Grunau and Anston (1995) and explored whether perceived direct gaze is easily detected by individuals with and without autism, utilizing a visual-search paradigm. Participants detected target faces with either direct gaze or averted gaze. Laterally averted faces were used to eliminate the involvement of lower perceptual characteristics such as symmetry, which were inherent with the "straight gaze" used by von Grunau and Anston. Both typically developed adults and children detected targets with direct gaze more quickly than those with averted gaze, but face inversion distorted this asymmetrical performance, suggesting the contribution of configurative facial processing. In contrast, children with autism were not affected by the gaze direction presented by realistic facial stimuli. They were, however, faster to detect straight gaze defined solely by local features, which suggests that their impairment might be specific to the detection of direct gaze presented within a facial context.
C1 Univ Tokyo, Grad Sch Arts & Sci, Dept Cognit & Behav Sci, Meguro Ku, Tokyo 1538902, Japan.
Natl Inst Special Educ, Tokyo, Japan.
RP Senju, A (reprint author), Univ Tokyo, Grad Sch Arts & Sci, Dept Cognit & Behav Sci, Meguro Ku, 3-8-1 Komaba, Tokyo 1538902, Japan.
EM atsushi@darwin.c.u-tokyo.ac.jp
RI Senju, Atsushi/C-4097-2008
OI Senju, Atsushi/0000-0002-8081-7170
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NR 58
TC 49
Z9 51
PU PSYCHOLOGY PRESS
PI HOVE
PA 27 CHURCH RD, HOVE BN3 2FA, EAST SUSSEX, ENGLAND
SN 1350-6285
J9 VIS COGN
JI Vis. Cogn.
PD NOV
PY 2005
VL 12
IS 8
BP 1474
EP 1496
DI 10.1080/13506280444000797
PG 23
WC Psychology, Experimental
SC Psychology
GA 984KN
UT WOS:000233303900003
ER
PT J
AU Schumann, CM
Amaral, DG
AF Schumann, CM
Amaral, DG
TI Stereological estimation of the number of neurons in the human
amygdaloid complex
SO JOURNAL OF COMPARATIVE NEUROLOGY
LA English
DT Article
DE amygdala; neuropathology; stereology; autism; medial temporal lobe;
anatomy
ID TEMPORAL-LOBE EPILEPSY; ALZHEIMERS-DISEASE; NUCLEUS; FRACTIONATOR;
BRAIN; CELLS; SIZE; HIPPOCAMPUS; EFFICIENCY; SHRINKAGE
AB Pathological changes in neuronal density in the amygdaloid complex have been associated with various neurological disorders. However, due to variable shrinkage during tissue processing, the only way to determine changes in neuron number unambiguously is to estimate absolute counts, rather than neuronal density. As the first stage in evaluating potential neuropathology of the amygdala in autism, the total number of neurons was estimated in the control human amygdaloid complex by using stereological sampling. The intact amygdaloid complex from one hemisphere of 10 brains was frozen and sectioned. One 100-mu m section was selected every 500 mu m and stained by the standard Nissl method. The entire amygdaloid complex was outlined and then further partitioned into five reliably defined subdivisions: 1) the lateral nucleus, 2) the basal nucleus, 3) the accessory basal nucleus, 4) the central nucleus, and 5) the remaining nuclei (including anterior cortical, anterior amygdaloid area, periamygdaloid cortex, medial, posterior cortical, nucleus of the lateral olfactory tract, amygdalohippocampal area, and intercalated nuclei). The number of neurons was measured by using an optical fractionator with Stereoinvestigator software. The mean number of neurons (X 10(6)) for each region was as follows: lateral nucleus 4.00, basal nucleus 3.24, accessory basal nucleus 1.28, central nucleus 0.36, remaining nuclei 3.33, and total amygdaloid complex 12.21. The stereological assessment of neuron number in the human amygdala provides an essential baseline for comparison of patient populations, such as autism, in which the amygdala may develop abnormally. To facilitate these types of analyses, this paper provides a detailed anatomical description of the methods used to define subdivisions of the human amygdaloid complex.
C1 Univ Calif Davis, MIND Inst, Med Ctr, Dept Psychiat & Behav Sci, Sacramento, CA 95817 USA.
RP Amaral, DG (reprint author), Univ Calif Davis, MIND Inst, Med Ctr, Dept Psychiat & Behav Sci, 2825 50th St, Sacramento, CA 95817 USA.
EM dgamaral@ucdavis.edu
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NR 30
TC 35
Z9 35
PU WILEY-LISS
PI HOBOKEN
PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 0021-9967
J9 J COMP NEUROL
JI J. Comp. Neurol.
PD OCT 31
PY 2005
VL 491
IS 4
BP 320
EP 329
DI 10.1002/cne.20704
PG 10
WC Neurosciences; Zoology
SC Neurosciences & Neurology; Zoology
GA 970DE
UT WOS:000232284600002
PM 16175550
ER
PT J
AU Nayate, A
Bradshaw, JL
Rinehart, NJ
AF Nayate, A
Bradshaw, JL
Rinehart, NJ
TI Autism and Asperger's disorder: Are they movement disorders involving
the cerebellum and/or basal ganglia?
SO BRAIN RESEARCH BULLETIN
LA English
DT Article
DE pervasive developmental disorders; motor dysfunction; frontostriatal
ID PARKINSONS-DISEASE; HUNTINGTONS-DISEASE; SPECTRUM DISORDER; BRAIN-STEM;
GAIT; CHILDREN; BEHAVIOR; ATAXIA; ABNORMALITIES; IMPAIRMENT
AB Autism and Asperger's disorder (AD) are childhood developmental disorders of unknown aetiology. Autism and AD share several behavioural features, and it is not clear whether they are distinct disorders or variants of the same disorder. Recent studies indicate that disordered movement may be another feature of autism and AD, and that this may reflect dysfunction within the frontostriatal and/or cerebellar motor circuits. While disordered movement in autism and AD has been examined in a variety of ways, it is relatively under-researched compared to the cognitive, affective, and behavioural disturbances seen in these disorders. This review examines the role of the frontostriatal and cerebellar motor systems in the behavioural features of autism and AD, with gait as a proxy, and discusses difficulties with their diagnosis and their possible pathogenesis. (c) 2005 Elsevier Inc. All rights reserved.
C1 Monash Univ, Dept Psychol Med, Clayton, Vic 3168, Australia.
RP Nayate, A (reprint author), Monash Univ, Dept Psychol Med, Clayton, Vic 3168, Australia.
EM Ashwini.Nayate@med.monash.edu.au
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NR 56
TC 64
Z9 64
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0361-9230
J9 BRAIN RES BULL
JI Brain Res. Bull.
PD OCT 30
PY 2005
VL 67
IS 4
BP 327
EP 334
DI 10.1016/j.brainresbull.2005.07.011
PG 8
WC Neurosciences
SC Neurosciences & Neurology
GA 973VO
UT WOS:000232550900010
PM 16182941
ER
PT J
AU Skinner, SR
Ng, C
McDonald, A
Walters, T
AF Skinner, SR
Ng, C
McDonald, A
Walters, T
TI A patient with autism and severe depression: medical and ethical
challenges for an adolescent medicine unit
SO MEDICAL JOURNAL OF AUSTRALIA
LA English
DT Article
ID DEPOT-MEDROXYPROGESTERONE ACETATE; BONE-MINERAL DENSITY; INTRAUTERINE
SYSTEM; MENORRHAGIA; SAFETY; WOMEN
AB An adolescent with autism and intellectual disability presented with severe depression related to menstruation.
Because of the complex medical, psychiatric and ethical issues involved, her care was coordinated by a hospital-based adolescent medicine unit.
After trials of other therapies over an extended period and interdisciplinary and intersectoral case conferencing, it was decided that hysterectomy was the most appropriate management.
This case highlights the complexity of adolescent health care in a tertiary hospital, the importance of intersectoral cooperation between hospital and community, and the integral role of interdisciplinary care of adolescent patients with chronic conditions.
C1 Princess Margaret Hosp Children, Sch Paediat & Child Hlth, Perth, WA 6840, Australia.
Univ Western Australia, Sch Paediat & Child Hlth, Perth, WA 6009, Australia.
Kind Edward Mem Hosp Women, Perth, WA, Australia.
RP Skinner, SR (reprint author), Princess Margaret Hosp Children, Sch Paediat & Child Hlth, GPO Box D184, Perth, WA 6840, Australia.
EM rachels@ichr.uwa.edu.au
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NR 16
TC 9
Z9 9
PU AUSTRALASIAN MED PUBL CO LTD
PI SYDNEY
PA LEVEL 1, 76 BERRY ST, SYDNEY, NSW 2060, AUSTRALIA
SN 0025-729X
J9 MED J AUSTRALIA
JI Med. J. Aust.
PD OCT 17
PY 2005
VL 183
IS 8
BP 422
EP 424
PG 3
WC Medicine, General & Internal
SC General & Internal Medicine
GA 983KB
UT WOS:000233229200010
PM 16225449
ER
PT J
AU Seeman, C
AF Seeman, C
TI Realizing the college dream with autism or Asperger syndrome: A parent's
guide to student success.
SO LIBRARY JOURNAL
LA English
DT Book Review
C1 Univ Toledo Libs, Toledo, OH 43606 USA.
RP Seeman, C (reprint author), Univ Toledo Libs, 2801 W Bancroft St, Toledo, OH 43606 USA.
CR PALMER A, 2005, REALIZING COLL DREAM
NR 1
TC 0
Z9 0
PU BOWKER MAGAZINE GROUP CAHNERS MAGAZINE DIVISION
PI NEW YORK
PA 249 W 17TH ST, NEW YORK, NY 10011 USA
SN 0363-0277
J9 LIBR J
JI Libr. J.
PD OCT 15
PY 2005
VL 130
IS 17
BP 72
EP 72
PG 1
WC Information Science & Library Science
SC Information Science & Library Science
GA 041XO
UT WOS:000237490200163
ER
PT J
AU Frith, U
Happe, F
AF Frith, U
Happe, F
TI Autism spectrum disorder
SO CURRENT BIOLOGY
LA English
DT Editorial Material
C1 UCL Inst Cognit Neurosci, London WC1N 3AR, England.
Inst Psychiat, Social Genet & Dev Psychiat Ctr, London SE5 8AF, England.
RP Frith, U (reprint author), UCL Inst Cognit Neurosci, 17 Queen Sq, London WC1N 3AR, England.
RI Frith, Uta/C-1757-2008
OI Frith, Uta/0000-0002-9063-4466
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Klin A, 2002, AM J PSYCHIAT, V159, P895, DOI 10.1176/appi.ajp.159.6.895
Pelphrey KA, 2005, BRAIN, V128, P1038, DOI 10.1093/brain/awh404
Sainsbury C., 2000, MARTIAN PLAYGROUND
NR 10
TC 30
Z9 31
PU CELL PRESS
PI CAMBRIDGE
PA 1100 MASSACHUSETTS AVE, CAMBRIDGE, MA 02138 USA
SN 0960-9822
J9 CURR BIOL
JI Curr. Biol.
PD OCT 11
PY 2005
VL 15
IS 19
BP R786
EP R790
DI 10.1016/j.cub.2005.09.033
PG 5
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA 976QK
UT WOS:000232748100008
PM 16213805
ER
PT J
AU Faham, M
Zheng, JB
Moorhead, M
Fakhrai-Rad, H
Namsaraev, E
Wong, K
Wang, ZY
Chow, SG
Lee, L
Suyenaga, K
Reichert, J
Boudreau, A
Eberle, J
Bruckner, C
Jain, M
Karlin-Neumann, G
Jones, HB
Willis, TD
Buxbaum, JD
Davis, RW
AF Faham, M
Zheng, JB
Moorhead, M
Fakhrai-Rad, H
Namsaraev, E
Wong, K
Wang, ZY
Chow, SG
Lee, L
Suyenaga, K
Reichert, J
Boudreau, A
Eberle, J
Bruckner, C
Jain, M
Karlin-Neumann, G
Jones, HB
Willis, TD
Buxbaum, JD
Davis, RW
TI Multiplexed variation scanning for 1,000 amplicons in hundreds of
patients using mismatch repair detection (MRD) on tag arrays
SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF
AMERICA
LA English
DT Article
DE association studies; autism; high-throughput technology; variation
scanning
ID SINGLE-NUCLEOTIDE POLYMORPHISMS; LINKAGE DISEQUILIBRIUM; SUSCEPTIBILITY
GENE; GENOMEWIDE SCREEN; AUTISM; ASSOCIATION; DISEASE; CANDIDATE;
VARIANTS; BREAST
AB Identification of the genetic basis of common disease may require comprehensive sequence analysis of coding regions and regulatory elements in patients and controls to find genetic effects caused by rare or heterogeneous mutations. In this study, we demonstrate how mismatch repair detection on tag arrays can be applied in a case-control study. Mismatch repair detection allows >1,000 amplicons to be screened for variations in a single laboratory reaction. Variation scanning in 939 amplicons, mostly in coding regions within a linkage peak, was done for 372 patients and 404 controls. In total, >180 Mb of DNA was scanned. Several variants more prevalent in patients than in controls were identified. This study demonstrates an approach to the discovery of susceptibility genes for common disease: large-scale direct sequence comparison between patients and controls. We believe this approach can be scaled up to allow sequence comparison in the whole-genome coding regions among large sets of cases and controls at a reasonable cost in the near future.
C1 ParAllele BioSci, San Francisco, CA 94080 USA.
Stanford Genome Technol Ctr, Palo Alto, CA 94304 USA.
CUNY Mt Sinai Sch Med, Greater New York Autism Res Ctr Excellence, New York, NY 10029 USA.
CUNY Mt Sinai Sch Med, Greater New York Autism Res Ctr Excellence, Seaver Autism Res Ctr, New York, NY 10029 USA.
CUNY Mt Sinai Sch Med, Lab Mol Neuropsychiat, Dept Psychiat, New York, NY 10029 USA.
CUNY Mt Sinai Sch Med, Lab Mol Neuropsychiat, Dept Neurobiol, New York, NY 10029 USA.
RP Faham, M (reprint author), ParAllele BioSci, 7300 Shoreline Court, San Francisco, CA 94080 USA.
EM malek@p-gene.com; dbowe@stanford.edu
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NR 33
TC 18
Z9 20
PU NATL ACAD SCIENCES
PI WASHINGTON
PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA
SN 0027-8424
J9 P NATL ACAD SCI USA
JI Proc. Natl. Acad. Sci. U. S. A.
PD OCT 11
PY 2005
VL 102
IS 41
BP 14717
EP 14722
DI 10.1073/pnas.0506677102
PG 6
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 974PJ
UT WOS:000232603600044
PM 16203980
ER
PT J
AU Turner, JR
Kellar, KJ
AF Turner, JR
Kellar, KJ
TI Nicotinic cholinergic receptors in the rat cerebellum: Multiple
heteromeric subtypes
SO JOURNAL OF NEUROSCIENCE
LA English
DT Article
DE nicotinic receptor; acetylcholine; cerebellum; rat; receptor; antibody
ID ACETYLCHOLINE-RECEPTOR; DOPAMINE RELEASE; BETA-4 SUBUNITS;
BINDING-SITES; HUMAN BRAIN; EXPRESSION; ALPHA-3-BETA-4; PHARMACOLOGY;
NEURONS; AUTISM
AB Nicotinic receptors (nAChRs) in the cerebellum have been implicated in the pathology of autism spectrum disorders (Lee et al., 2002; Martin-Ruiz et al., 2004). The subtypes of nAChRs in the cerebellum are not known in any detail, except that, in addition to the homomeric alpha 7 subtype, there appears to be one or more heteromeric subtypes consisting of combinations of alpha and beta subunits. To begin to better understand the potential roles of these heteromeric nAChRs in cerebellar circuitry and their potential as targets for nicotinic drugs, we investigated their subunit composition. Using subunit-selective antibodies in sequential immunoprecipitation assays, we detected six structurally distinct heteromeric nAChR populations in the rat cerebellum. Among these were several subtypes that have not been encountered previously, including alpha 3 alpha 4 alpha 2 and alpha 3 alpha 4 alpha 4 nAChRs. This diversity suggests that nAChRs play multiple roles in cerebellar physiology.
C1 Georgetown Univ, Sch Med, Dept Pharmacol, Washington, DC 20057 USA.
RP Kellar, KJ (reprint author), Georgetown Univ, Sch Med, Dept Pharmacol, 3900 Reservoir Rd, Washington, DC 20057 USA.
EM kellark@georgetown.edu
RI Turner, Jill/E-5678-2014
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NR 47
TC 48
Z9 48
PU SOC NEUROSCIENCE
PI WASHINGTON
PA 11 DUPONT CIRCLE, NW, STE 500, WASHINGTON, DC 20036 USA
SN 0270-6474
J9 J NEUROSCI
JI J. Neurosci.
PD OCT 5
PY 2005
VL 25
IS 40
BP 9258
EP 9265
DI 10.1523/JNEUROSCI.2112-05.2005
PG 8
WC Neurosciences
SC Neurosciences & Neurology
GA 971BD
UT WOS:000232355200021
PM 16207885
ER
PT J
AU Ek, U
Fernell, E
Jacobson, L
AF Ek, U
Fernell, E
Jacobson, L
TI Cognitive and behavioural characteristics in blind children with
bilateral optic nerve hypoplasia
SO ACTA PAEDIATRICA
LA English
DT Article
DE optic nerve hypoplasia; ONH; cognitive; behaviour; autism
ID SYSTEM ABNORMALITIES; AUTISM; DISORDERS; DYSPLASIA; SPECTRUM;
MALFORMATIONS; INDIVIDUALS; DYSFUNCTION; POPULATION; CORTISOL
AB Aim: To describe cognitive and behavioural characteristics in a group of blind children with bilateral optic nerve hypoplasia (ONH). Methods: Data from records, parents, teachers, and repeated developmental assessments of 13 blind children with ONH born in 1988-1998 were analysed. All children had neuroimaging and/or hormonal evidence of midline malformations. They were all blind and able to communicate with speech. Results: Severe mood swings and temper tantrums were common, especially during the first years of life. Later in life, sluggish tempo, low frustration tolerance and a narrow range of interests were common. Autism had been diagnosed in 6/13 children, autistic-like condition (ALC) was found in another three. The behaviour of the remaining four children was not within the autism spectrum. Eight children had cognitive capacities within the normal or near-normal range; five had mental retardation. Autism/ALC was found in all cognitive subgroups. All children exhibited fluent speech and, of these, 12 had started to talk at the expected age, but had clear deficiencies in communicative ability.
Conclusion: These children had a common pattern of behavioural characteristics including autism spectrum disorders independent of intellectual capacities.
C1 Univ Stockholm, Dept Psychol, SE-10691 Stockholm, Sweden.
Tomteboda Resource Ctr, Stockholm, Sweden.
Astrid Lindgren Childrens Hosp, Dept Neuropaediat, Stockholm, Sweden.
RP Ek, U (reprint author), Univ Stockholm, Dept Psychol, SE-10691 Stockholm, Sweden.
EM uek@psychology.su.se
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NR 46
TC 18
Z9 18
PU TAYLOR & FRANCIS AS
PI OSLO
PA PO BOX 12 POSTHUSET, NO-0051 OSLO, NORWAY
SN 0803-5253
J9 ACTA PAEDIATR
JI Acta Paediatr.
PD OCT
PY 2005
VL 94
IS 10
BP 1421
EP 1426
DI 10.1080/08035250510037290
PG 6
WC Pediatrics
SC Pediatrics
GA 979HB
UT WOS:000232931900013
PM 16299874
ER
PT J
AU Bartolome, A
Bardliving, C
Rao, G
Tolosa, L
AF Bartolome, A
Bardliving, C
Rao, G
Tolosa, L
TI Fatty acid sensor for low-cost lifetime-assisted ratiometric sensing
using a fluorescent fatty acid binding protein
SO ANALYTICAL BIOCHEMISTRY
LA English
DT Article
DE fatty acid binding protein; lifetime-assisted ratiometric
modulation-based sensing; ruthenium; acrylodan
ID GENETICALLY-ENGINEERED PROTEIN; VARIABLE-FREQUENCY PHASE; MODULATION
DATA; FLUOROPHORES; DISEASE
AB Elevated free fatty acid (FA) levels lead to insulin resistance, hypertension, and microangiopathy, all of which are associated with type 2 diabetes. On the other hand, deficiencies of FA are indicative of certain neurodegenerative diseases, including autism. Thus, free FA levels are a diagnostic indicator for a variety of disorders. Here we describe the use of a commercially available FA binding protein labeled with acrylodan (ADIFAB), which we modified with a ruthenium metal-ligand complex with the intention of creating a low-cost FA sensor. The dual-labeled FA binding protein was used in lifetime-assisted ratiometric sensing (LARS) of oleic acid. For both steady-state and time-resolved luminescence decay experiments, the protein is responsive to oleic acid in the range of 0.02-4.7 mu M. The emission at 432 nm, which is associated with the acrylodan occupying the FA binding site, decreases in intensity and red shifts to 505 nm on the addition of oleic acid. The intensities of the 505-nm peak due to the acrylodan displaced from the binding site by FA and of the 610-nm emission peak of ruthenium remained nearly unchanged. Fitting of the fluorescence decay data using the method of least squares revealed three emitting components with lifetimes of approximately 0.60, 4.00, and 370 ns. Fractional intensities of the emitting species indicate that changes in modulation between 2 and 10 MHz on binding of the protein with oleic acid are due mainly to the 4.00-ns component. The 0.60- and 370-ns components are assigned to acrylodan (505 nm) and ruthenium, respectively. Note that because ruthenium has a lifetime that is two orders of magnitude longer than that of acrylodan, the FA measurements were carried out at excitation frequencies lower than what can be done with acrylodan alone. Thus, low-cost instrumentation can be designed for a practical FA sensor without sacrificing the quality of measurements. (C) 2005 Elsevier Inc. All rights reserved.
C1 Univ Maryland Baltimore Cty, Ctr Adv Sensor Technol Chem & Biochem Engn, Baltimore, MD 21250 USA.
RP Tolosa, L (reprint author), Univ Maryland Baltimore Cty, Ctr Adv Sensor Technol Chem & Biochem Engn, Baltimore, MD 21250 USA.
EM leah@umbc.edu
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NR 25
TC 11
Z9 12
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0003-2697
J9 ANAL BIOCHEM
JI Anal. Biochem.
PD OCT 1
PY 2005
VL 345
IS 1
BP 133
EP 139
DI 10.1016/j.ab.2005.07.030
PG 7
WC Biochemical Research Methods; Biochemistry & Molecular Biology;
Chemistry, Analytical
SC Biochemistry & Molecular Biology; Chemistry
GA 972CN
UT WOS:000232431700017
PM 16137630
ER
PT J
AU Demonceau, N
Roubertie, A
Cheminal, R
Leydet, J
Rivier, F
Echenne, B
AF Demonceau, N
Roubertie, A
Cheminal, R
Leydet, J
Rivier, F
Echenne, B
TI Genetics contribution to the understanding of autism
SO ARCHIVES DE PEDIATRIE
LA French
DT Review
DE autism, infantile; autistic disorders, genetics
ID SUSCEPTIBILITY GENE; LINKAGE; MUTATIONS; SCREEN; TWIN; 7Q
AB Autism is a pervasive developmental disorder characterised by an impairment in social interaction and in communication, with unusual behaviour. Genetic factors are predominent in autism pathogenesis, in contrast with the environmental factors that would modulate the phenotype. The genetic polymorphism and the phenotypic heterogeneity make the autism a complex disorder to study. Genetic research on families with multiple affected children and biochemical mechanisms studies represent the sources for identifying the susceptibility genes in autism. (c) 2005 Elsevier SAS. Tous droits reserves.
C1 Hop Gui De Chauliac, Serv Neuroped, F-34295 Montpellier, France.
RP Demonceau, N (reprint author), Hop Gui De Chauliac, Serv Neuroped, 80 Ave A Fliche, F-34295 Montpellier, France.
EM n-demonceau@chu-montpellier.fr
CR American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th
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NR 19
TC 0
Z9 0
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI PARIS
PA 23 RUE LINOIS, 75724 PARIS, FRANCE
SN 0929-693X
J9 ARCH PEDIATRIE
JI Arch. Pediatr.
PD OCT
PY 2005
VL 12
IS 10
BP 1509
EP 1512
DI 10.1016/j.arcped.2005.06.007
PG 4
WC Pediatrics
SC Pediatrics
GA 983EL
UT WOS:000233213900012
PM 16102953
ER
PT J
AU Warreyn, P
Roeyers, H
De Groote, I
AF Warreyn, P
Roeyers, H
De Groote, I
TI Early social communicative behaviours of preschoolers with autism
spectrum disorder during interaction with their mothers
SO AUTISM
LA English
DT Article
DE autism spectrum disorder; imitation; joint attention; play; social
communicative development
ID JOINT ATTENTION; SYMBOLIC PLAY; PRETEND PLAY; YOUNG-CHILDREN; IMITATION;
INFANTS; ORIGINS; LEVEL; MIND; LANGUAGE
AB The present study examined spontaneous symbolic play, declarative joint attention, social referencing and imitation of symbolic play in 3- to 6-year-old children with an autism spectrum disorder (ASD; n = 20) during interaction with their mothers. Compared to a control group (n = 20) matched on age and IQ, the children with ASD initiated less joint attention with their mothers when confronted with a pleasant event and they showed a tendency to play less symbolically and more non-functionally. Contrary to expectations, children with ASD showed no social referencing or imitation deficits. Interestingly, two clusters of intercorrelating behaviours were found in the ASD group: one suggesting symbolic or metarepresentational abilities, the other comprising interpersonal behaviours. The findings support the hypothesis that early social communicative abilities may follow a different developmental pathway in ASD, and stress the importance of a contextual factor, namely the presence of the mother.
C1 Ghent Univ, Res Grp Dev Disorders, B-9000 Ghent, Belgium.
RP Warreyn, P (reprint author), Ghent Univ, Res Grp Dev Disorders, H Dunantlaan 2, B-9000 Ghent, Belgium.
EM Petra.Warreyn@UGent.be
CR American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th
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Zink I., 2002, N CDIS LIJSTEN COMMU
NR 51
TC 20
Z9 22
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1362-3613
J9 AUTISM
JI Autism
PD OCT
PY 2005
VL 9
IS 4
BP 342
EP 361
DI 10.1177/1362361305056076
PG 20
WC Psychology, Developmental
SC Psychology
GA 973XR
UT WOS:000232556400002
PM 16155053
ER
PT J
AU Sperry, LA
Mesibov, GB
AF Sperry, LA
Mesibov, GB
TI Perceptions of social challenges of adults with autism spectrum disorder
SO AUTISM
LA English
DT Article
DE adults; ASD; personal perspectives; social challenges
ID PROGRAM
AB This study examines perceptions of social challenges by adults with autism spectrum disorder (ASD). The investigators analyzed three separate, regularly scheduled social group meetings attended by a total of 18 adults with ASD where the activity was a discussion of social issues. Participants generated social questions and challenges they had encountered as a result of having autism. The questions were presented to the group for a discussion of potential solutions. Written and audio data were collected and a member check was completed. The data were plumbed for key words and emergent themes to identify major social challenges as viewed by adults with ASD. The emergent themes included relationships at work, developing and maintaining personal relationships, appropriate behaviors around members of the opposite sex, and personal perspectives on having ASD.
C1 Univ Colorado, Denver, CO 80202 USA.
Univ N Carolina, Chapel Hill, NC USA.
RP Sperry, LA (reprint author), 2 S Juniper Court, Golden, CO 80401 USA.
EM lasperry@hotmail.com
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NR 23
TC 17
Z9 18
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1362-3613
J9 AUTISM
JI Autism
PD OCT
PY 2005
VL 9
IS 4
BP 362
EP 376
DI 10.1177/1362361305056077
PG 15
WC Psychology, Developmental
SC Psychology
GA 973XR
UT WOS:000232556400003
PM 16155054
ER
PT J
AU Hastings, RP
Kovshoff, H
Brown, T
Ward, NJ
Degli Espinosa, F
Remington, B
AF Hastings, RP
Kovshoff, H
Brown, T
Ward, NJ
Degli Espinosa, F
Remington, B
TI Coping strategies in mothers and fathers of preschool and school-age
children with autism
SO AUTISM
LA English
DT Article
DE coping; fathers; mothers; preschool children; school-age children;
stress
ID GENDER DIFFERENCES; DEVELOPMENTAL-DISABILITIES; MENTAL-RETARDATION;
BEHAVIOR PROBLEMS; YOUNG-CHILDREN; FAMILY STRESS; PARENTS; PERCEPTIONS;
INTERVENTION; ADAPTATION
AB Despite the theoretical and demonstrated empirical significance of parental coping strategies for the wellbeing of families of children with disabilities, relatively little research has focused explicitly on coping in mothers and fathers of children with autism. In the present study, 89 parents of preschool children and 46 parents of school-age children completed a measure of the strategies they used to cope with the stresses of raising their child with autism. Factor analysis revealed four reliable coping dimensions: active avoidance coping, problem-focused coping, positive coping, and religious/denial coping. Further data analysis suggested gender differences on the first two of these dimensions but no reliable evidence that parental coping varied with the age of the child with autism. Associations were also found between coping strategies and parental stress and mental health. Practical implications are considered including reducing reliance on avoidance coping and increasing the use of positive coping strategies.
C1 Univ Wales, Sch Psychol, Bangor LL57 2DG, Gwynedd, Wales.
Univ Southampton, Southampton SO9 5NH, Hants, England.
RP Hastings, RP (reprint author), Univ Wales, Sch Psychol, Bangor LL57 2DG, Gwynedd, Wales.
EM r.hastings@bangor.ac.uk
RI Hastings, Richard/D-9657-2013
OI Hastings, Richard/0000-0002-0495-8270
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NR 43
TC 106
Z9 110
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1362-3613
J9 AUTISM
JI Autism
PD OCT
PY 2005
VL 9
IS 4
BP 377
EP 391
DI 10.1177/1362361305056078
PG 15
WC Psychology, Developmental
SC Psychology
GA 973XR
UT WOS:000232556400004
PM 16155055
ER
PT J
AU Gadow, KD
Devincent, CJ
Pomeroy, J
Azizian, A
AF Gadow, KD
Devincent, CJ
Pomeroy, J
Azizian, A
TI Comparison of DSM-IV symptoms in elementary school-age children with PDD
versus clinic and community samples
SO AUTISM
LA English
DT Article
DE Asperger syndrome; autism; community survey; PDD-NOS; pervasive
developmental disorder
ID PERVASIVE DEVELOPMENTAL DISORDER; DEFICIT HYPERACTIVITY DISORDER;
AUTISTIC DISORDER; PRESCHOOL-CHILDREN; ASPERGER-SYNDROME;
TOURETTE-SYNDROME; FIELD TRIAL; PSYCHOACTIVE MEDICINES; PREVALENCE; ADHD
AB This study compares DSM-IV symptoms in children (ages 6 to 12 years) with pervasive developmental disorder (PDD), clinic controls, and community-based samples. Parents/ teachers completed the Child Symptom Inventory-4 for four samples: PDD (N = 284/284) and non-PDD psychiatric clinic referrals (N = 189/181 1) and pupils in regular (N = 385/404) and special (N = 61/60) education classes. The PDD group received higher symptom severity ratings than the regular education group, but was similar to the non-PDD clinic sample. Screening prevalence rates were highest for ADHD, ODD, and generalized anxiety disorder. PDD subtypes exhibited differentially higher rates of psychiatric symptoms. The magnitude of rater and gender differences in symptom severity ratings was modest. Clinic-referred children with PDD exhibit a pattern of psychiatric symptoms highly similar to non-PDD clinic referrals. Although much additional research is needed on comorbidity, these symptoms have important treatment implications.
C1 SUNY Stony Brook, Dept Psychiat & Behav Sci, Stony Brook, NY 11794 USA.
SUNY, New York, NY USA.
RP Gadow, KD (reprint author), SUNY Stony Brook, Dept Psychiat & Behav Sci, Putnam Hall,S Campus, Stony Brook, NY 11794 USA.
EM kenneth.gadow@stonybrook.edu
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NR 53
TC 149
Z9 150
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1362-3613
J9 AUTISM
JI Autism
PD OCT
PY 2005
VL 9
IS 4
BP 392
EP 415
DI 10.1177/1362361305056079
PG 24
WC Psychology, Developmental
SC Psychology
GA 973XR
UT WOS:000232556400005
PM 16155056
ER
PT J
AU Duarte, CS
Bordin, IA
Yazigi, L
Mooney, J
AF Duarte, CS
Bordin, IA
Yazigi, L
Mooney, J
TI Factors associated with stress in mothers of children with autism
SO AUTISM
LA English
DT Article
DE autism; maternal; personality; pervasive developmental disorders; stress
ID PROGNOSTIC RATING-SCALE; DOUBLE ABCX MODEL; DIAGNOSTIC EFFICIENCY;
MENTAL-RETARDATION; RORSCHACH MEASURES; PARENTAL STRESS; SOCIAL SUPPORT;
DISORDERS; FAMILY; MMPI
AB The objective of this case-control study was to investigate the determinants of maternal stress in mothers of children with autism. Mothers of 31 children with autism from mental health clinics were matched by child age/gender and mother age to 31 mothers of children without mental health problems, drawn from public schools and a primary care unit. Logistic regression models showed that the presence of stress in mothers was primarily associated with having a child with autism. However, poor expression of affect, little interest in people, being an older mother, and having a younger child also contributed to increased stress levels. Although having a child with autism was the main factor responsible for stress, the presence of the other factors further increased maternal stress. The implication is that a subgroup of mothers of children with autism is more prone to experience stress, thus requiring special attention from mental health professionals.
C1 Columbia Univ, NY State Psychiat Inst, Div Child & Adolescent Psychiat, New York, NY 10032 USA.
Univ Fed Sao Paulo, Sao Paulo, Brazil.
RP Duarte, CS (reprint author), Columbia Univ, NY State Psychiat Inst, Div Child & Adolescent Psychiat, 1051 Riverside Dr Unit 43, New York, NY 10032 USA.
EM duartec@childpsych.columbia.edu
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NR 42
TC 51
Z9 54
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1362-3613
J9 AUTISM
JI Autism
PD OCT
PY 2005
VL 9
IS 4
BP 416
EP 427
DI 10.1177/1362361305056081
PG 12
WC Psychology, Developmental
SC Psychology
GA 973XR
UT WOS:000232556400006
PM 16155057
ER
PT J
AU Castelli, F
AF Castelli, F
TI Understanding emotions from standardized facial expressions in autism
and normal development
SO AUTISM
LA English
DT Article
DE amygdala; autism; emotion; facial expressions; mentalizing
ID BILATERAL AMYGDALA DAMAGE; ASPERGER-SYNDROME; CHILDS APPRAISAL;
RECOGNITION; MIND; PERCEPTION; RESPONSES; ADULTS; BRAIN; DISTRESS
AB The study investigated the recognition of standardized facial expressions of emotion (anger, fear, disgust, happiness, sadness, surprise) at a perceptual level (experiment 1) and at a semantic level (experiments 2 and 3) in children with autism (N = 20) and normally developing children (N = 20). Results revealed that children with autism were as able as controls to recognize all six emotions with different intensity levels, and that they made the same type of errors. These negative findings are discussed in relation to (1) previous data showing specific impairment in autism in recognizing the belief-based expression of surprise, (2) previous data showing specific impairment in autism in recognizing fear, and (3) the convergence of findings that individuals with autism, like patients with amygdala damage, pass a basic emotions recognition test but fail to recognize more complex stimuli involving the perception of faces or part of faces.
C1 CALTECH, Pasadena, CA 91125 USA.
RP Castelli, F (reprint author), CALTECH, HSS 228-77, Pasadena, CA 91125 USA.
EM fulvia@hss.caltech.edu
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NR 37
TC 113
Z9 113
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1362-3613
J9 AUTISM
JI Autism
PD OCT
PY 2005
VL 9
IS 4
BP 428
EP 449
DI 10.1177/1362361305056082
PG 22
WC Psychology, Developmental
SC Psychology
GA 973XR
UT WOS:000232556400007
PM 16155058
ER
PT J
AU May, F
AF May, F
TI Helping children with autism learn: Treatment approaches for parents and
professionals
SO AUTISM
LA English
DT Book Review
C1 Inst Child Hlth, London, England.
RP May, F (reprint author), Inst Child Hlth, London, England.
CR SEIGEL B, 2003, HELPING CHILDREN AUT
NR 1
TC 0
Z9 0
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1362-3613
J9 AUTISM
JI Autism
PD OCT
PY 2005
VL 9
IS 4
BP 453
EP 455
DI 10.1177/1362361305056097
PG 3
WC Psychology, Developmental
SC Psychology
GA 973XR
UT WOS:000232556400010
ER
PT J
AU Tomasello, M
Carpenter, M
Call, J
Behne, T
Moll, H
AF Tomasello, M
Carpenter, M
Call, J
Behne, T
Moll, H
TI Understanding and sharing intentions: The origins of cultural cognition
SO BEHAVIORAL AND BRAIN SCIENCES
LA English
DT Review
DE collaboration; cooperation; cultural learning; culture; evolutionary
psychology; intentions; shared intentionality; social cognition; social
learning; theory of mind; joint attention
ID CHIMPANZEES PAN-TROGLODYTES; JOINT ATTENTION; 12-AND 18-MONTH-OLDS;
ACCIDENTAL ACTIONS; INFANT CHIMPANZEE; YOUNG-CHILDREN; FOLLOW GAZE;
AUTISM; IMITATION; CONSPECIFICS
AB We propose that the crucial difference between human cognition and that of other species is the ability to participate with others in collaborative activities with shared goals and intentions: shared intentionality. Participation in such activities requires not only especially powerful forms of intention reading and cultural learning, but also a unique motivation to share psychological states with others and unique forms of cognitive representation for doing so. The result of participating in these activities is species-unique forms of cultural cognition and evolution, enabling everything from the creation and use of linguistic symbols to the construction of social norms and individual beliefs to the establishment of social institutions. In support of this proposal we argue and present evidence that great apes (and some children with autism) understand the basics of intentional action, but they still do not participate in activities involving joint intentions and attention (shared intentionality). Human children's skills of shared intentionality develop gradually during the first 14 months of life as two ontogenetic pathways intertwine: (1) the general ape line of understanding others as animate, goal-directed, and intentional agents; and (2) a species-unique motivation to share emotions, experience, and activities with other persons. The developmental outcome is children's ability to construct dialogic cognitive representations, which enable them to participate in earnest in the collectivity that is human cognition.
C1 Max Planck Inst Evolutionary Anthropol, Dept Dev & Comparat Psychol, D-04103 Leipzig, Germany.
RP Tomasello, M (reprint author), Max Planck Inst Evolutionary Anthropol, Dept Dev & Comparat Psychol, D-04103 Leipzig, Germany.
EM tornas@eva.rnpg.de; carpenter@eva.mpg.de; call@eva.mpg.de;
behne@eva.mpg.de; rnoll@eva.mpg.de
RI Galantucci, Bruno/E-5770-2010
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NR 149
TC 1055
Z9 1088
PU CAMBRIDGE UNIV PRESS
PI NEW YORK
PA 40 WEST 20TH ST, NEW YORK, NY 10011-4211 USA
SN 0140-525X
J9 BEHAV BRAIN SCI
JI Behav. Brain Sci.
PD OCT
PY 2005
VL 28
IS 5
BP 675
EP +
DI 10.1017/S0140525X05000129
PG 26
WC Psychology, Biological; Behavioral Sciences; Neurosciences
SC Psychology; Behavioral Sciences; Neurosciences & Neurology
GA 979NJ
UT WOS:000232949000018
PM 16262930
ER
PT J
AU Charman, T
AF Charman, T
TI Why do individuals with autism lack the motivation or capacity to share
intentions?
SO BEHAVIORAL AND BRAIN SCIENCES
LA English
DT Editorial Material
ID BEHAVIORAL REENACTMENT; STIMULUS ENHANCEMENT; COGNITION; CHILDREN;
INFANTS; OTHERS
AB Tomasello et al. highlight how in combination cognitive impairments and affective impairments help explain why individuals with autism do not enter fully into human culture. We query whether the motivational component is a later development in human ontogeny and whether the cognitive level of intention reading is intact in autism. A key question is what neuropsychological impairments underlie this cognitive-affective impairment.
C1 Inst Child Hlth, Behav & Brain Sci Unit, London WC1N 1EH, England.
RP Charman, T (reprint author), Inst Child Hlth, Behav & Brain Sci Unit, 30 Guilford St, London WC1N 1EH, England.
EM t.charman@ich.ucl.ac.uk
RI Charman, Tony/A-2085-2014
OI Charman, Tony/0000-0003-1993-6549
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NR 25
TC 1
Z9 2
PU CAMBRIDGE UNIV PRESS
PI NEW YORK
PA 40 WEST 20TH ST, NEW YORK, NY 10011-4211 USA
SN 0140-525X
J9 BEHAV BRAIN SCI
JI Behav. Brain Sci.
PD OCT
PY 2005
VL 28
IS 5
BP 695
EP +
PG 11
WC Psychology, Biological; Behavioral Sciences; Neurosciences
SC Psychology; Behavioral Sciences; Neurosciences & Neurology
GA 979NJ
UT WOS:000232949000023
ER
PT J
AU Dymond, S
McHugh, L
AF Dymond, S
McHugh, L
TI Symbolic behavior and perspective-taking are forms of derived relational
responding and can be learned
SO BEHAVIORAL AND BRAIN SCIENCES
LA English
DT Editorial Material
ID EQUIVALENCE-RELATIONS; JOINT ATTENTION; CHILDREN; INDIVIDUALS; AUTISM
AB Numerous questions remain unanswered concerning the functional determinants of symbolic behavior and perspective-taking, particularly regarding the capabilities of children with autism. An alternative approach that considers these behaviors to be forms of derived relational responding allows for the design of functional intervention programs to establish such repertoires in individuals for whom they are absent.
C1 APU, Dept Psychol, Cambridge CB1 1PT, England.
Univ Coll Swansea, Dept Psychol, Swansea SA2 8PP, W Glam, Wales.
RP Dymond, S (reprint author), APU, Dept Psychol, Cambridge CB1 1PT, England.
EM s.dymond@apu.ac.uk; l.mchugh@swansea.ac.uk
RI Dymond, Simon/D-8503-2014
OI Dymond, Simon/0000-0003-1319-4492
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NR 18
TC 0
Z9 0
PU CAMBRIDGE UNIV PRESS
PI NEW YORK
PA 40 WEST 20TH ST, NEW YORK, NY 10011-4211 USA
SN 0140-525X
J9 BEHAV BRAIN SCI
JI Behav. Brain Sci.
PD OCT
PY 2005
VL 28
IS 5
BP 697
EP +
PG 10
WC Psychology, Biological; Behavioral Sciences; Neurosciences
SC Psychology; Behavioral Sciences; Neurosciences & Neurology
GA 979NJ
UT WOS:000232949000025
ER
PT J
AU Mundy, P
AF Mundy, P
TI Motivation, self-regulation, and the neurodevelopment of intention
sharing
SO BEHAVIORAL AND BRAIN SCIENCES
LA English
DT Editorial Material
ID JOINT ATTENTION; NONVERBAL-COMMUNICATION; NEUROCOGNITIVE FUNCTION;
CHILDREN; AUTISM; PERCEPTION; BEHAVIOR; CORTEX; SKILLS
AB Research on the affective and neurodevelopmental correlates of infant joint attention skills support several of the hypotheses raised by Tomasello et al. regarding the development of the capacity to share intention with others. In addition, research and theory suggests that self-awareness and self-regulatory processes may play a role in the development of this vital human ability domain.
C1 Univ Miami, Dept Psychol, Coral Gables, FL 33156 USA.
RP Mundy, P (reprint author), Univ Miami, Dept Psychol, Coral Gables, FL 33156 USA.
EM pmundy@miami.edu
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NR 27
TC 1
Z9 1
PU CAMBRIDGE UNIV PRESS
PI NEW YORK
PA 40 WEST 20TH ST, NEW YORK, NY 10011-4211 USA
SN 0140-525X
J9 BEHAV BRAIN SCI
JI Behav. Brain Sci.
PD OCT
PY 2005
VL 28
IS 5
BP 709
EP +
PG 11
WC Psychology, Biological; Behavioral Sciences; Neurosciences
SC Psychology; Behavioral Sciences; Neurosciences & Neurology
GA 979NJ
UT WOS:000232949000039
ER
PT J
AU Verbeke, E
Peeters, W
Kerkhof, I
Bijttebier, P
Steyaert, J
Wagemans, J
AF Verbeke, E
Peeters, W
Kerkhof, I
Bijttebier, P
Steyaert, J
Wagemans, J
TI Lack of motivation to share intentions: Primary deficit in autism?
SO BEHAVIORAL AND BRAIN SCIENCES
LA English
DT Editorial Material
ID JOINT ATTENTION; ASPERGER-SYNDROME; CENTRAL COHERENCE; MIND;
INDIVIDUALS; ADULTS
AB We review evidence regarding Tomasello et al.'s proposal that individuals with autism understand intentions but fail socially because of a lack of motivation to share intentions. We argue that they are often motivated to understand others but fail because they lack the perceptual integration skills that are needed to apply their basically intact theory of mind skill in complex social situations.
C1 Katholieke Univ Leuven, Dept Psychol Psychodiagnost & Psychopathol, B-3000 Louvain, Belgium.
UZ Leuven, Acad Hosp, Fac Med, B-3000 Louvain, Belgium.
Katholieke Univ Leuven, Dept Psychol, Expt Psychol Lab, B-3000 Louvain, Belgium.
RP Verbeke, E (reprint author), Katholieke Univ Leuven, Dept Psychol Psychodiagnost & Psychopathol, B-3000 Louvain, Belgium.
EM eline.verbeke@psy.kuleuven.ac.be; wilfried.peeters@uz.kuleuven.ac.be;
inneke.kerkhof@psu.kuleuven.ac.be;
patricia.bijftebier@psu.kuleuven.ac.be;
jean.steyaert@psu.kuleuven.ac.be; johan.wagemans@psu.kuleuven.ac.be
RI Steyaert, Jean/B-5326-2015
OI Steyaert, Jean/0000-0003-2512-4694
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WARREYN P, 2004, J COGNITIVE BEHAV PS, V6, P131
NR 21
TC 4
Z9 5
PU CAMBRIDGE UNIV PRESS
PI NEW YORK
PA 40 WEST 20TH ST, NEW YORK, NY 10011-4211 USA
SN 0140-525X
J9 BEHAV BRAIN SCI
JI Behav. Brain Sci.
PD OCT
PY 2005
VL 28
IS 5
BP 718
EP +
PG 11
WC Psychology, Biological; Behavioral Sciences; Neurosciences
SC Psychology; Behavioral Sciences; Neurosciences & Neurology
GA 979NJ
UT WOS:000232949000048
ER
PT J
AU Zhang, X
Ji, CY
AF Zhang, X
Ji, CY
TI Autism and mental retardation of young children in China
SO BIOMEDICAL AND ENVIRONMENTAL SCIENCES
LA English
DT Article
DE autism; mental retardation; epidemiology; China
ID DEVELOPMENTAL-DISABILITIES; PREVALENCE; POPULATION; DISORDERS; HEALTH
AB Objective: To understand the prevalence and rehabilitation status of autism and mental retardation in China. Methods: Screening test and clinical assessment were conducted for the diagnosis of autism and mental retardation. The assessment included investigation of the histories of medical conditions and development of these two disorders, utilization and needs for the rehabilitation service, and related intellectual and behavioral appraisal. Results: Among the 7345 children investigated, the prevalence of autism disorder was 1.10 cases per 1000 children aged 2-6 years (95% CI = 0.34 to 2.54), and the prevalence of mental retardation was 10.76 cases per 1000 children (95% CI = 8.40 to 13.12). All the children suffering from autistic disorder were intellectually disabled, whereas 31.0% of the non-autism mental retardates had other disabilities. The medical conditions prior to birth and perinatal period were important potential factors for autism. Half of the autistic children and 84% of the children with non-autism mental retardation had never received any rehabilitative service. Conclusions: The prevalence of autistic disorder in children aged 2-6 years in Tianjin is rather high. It is urgent to improve the status of the autistic and intelligently disabled young children in China. In order to upgrade the level of early diagnostic and improve the intervention to autism and mental retardation, public awareness and training courses should be heightened.
C1 Peking Univ, Hlth Sci Ctr, Inst Child & Adolescent Hlth, Beijing 100083, Peoples R China.
Tianjin Med Univ, Sch Publ Hlth, Dept Child & Adolescent Hlth, Tianjin 300070, Peoples R China.
RP Zhang, X (reprint author), Peking Univ, Hlth Sci Ctr, Inst Child & Adolescent Hlth, 38,Xueyuan Rd, Beijing 100083, Peoples R China.
EM zhx0628@yahoo.com.cn
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NR 22
TC 25
Z9 25
PU CHINESE ACAD PREVENTIVE MEDICINE
PI ORLANDO
PA C/O ACADEMIC PRESS INC, 6277 SEA HARBOR DR, ORLANDO, FL 32887-4900 USA
SN 0895-3988
J9 BIOMED ENVIRON SCI
JI Biomed. Environ. Sci.
PD OCT
PY 2005
VL 18
IS 5
BP 334
EP 340
PG 7
WC Environmental Sciences; Public, Environmental & Occupational Health
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health
GA 975GY
UT WOS:000232650200009
PM 16370317
ER
PT J
AU Halberg, F
Cornelissen, G
Panksepp, J
Otsuka, K
Johnson, D
AF Halberg, F
Cornelissen, G
Panksepp, J
Otsuka, K
Johnson, D
TI Chronomics of autism and suicide
SO BIOMEDICINE & PHARMACOTHERAPY
LA English
DT Article; Proceedings Paper
CT 5th International Symposium Workshop on Circadian Rhythms and Clinical
Chronotherapy
CY NOV 06, 2004
CL Tokyo, JAPAN
DE autism; chronome; melatonin; non-photic cycles; suicide; transyear
ID GEOMAGNETIC-ACTIVITY; SEASON; BIRTH; MELATONIN; DISORDER; SCHIZOPHRENIA;
CHILDREN; PREVALENCE; PROLACTIN; PSYCHOSIS
AB We examine whether autism may be influenced by non-photic environmental factors, among others, in it California database consisting of the number of cases added quarterly to the system between 1993 and 2004. Instead of a precise calendar (1.0)-year-long spectral component, we detect unseen primarily helio- and geomagnetic signatures. including a newly discovered near-transyear of 1.09-year length, In this it overrides any undetected seasonal effects, the topic of much previous unrewarding rescarch, also analysed herein without overcoming the limitation by stacking. Since we could not get additional data on autism, data on suicides, the final "detachment" and failure to bond, were also analyzed, again revealing a spectrum of non-photic signatures. What we do not see and do not anticipate can exist and can override the seasons, as resolved time-microscopically by chronomics, the study of chronomes (time structures), Just is spatial microscopy and electron microscopy resolved infectious agents, so does microscopy in time resolve the signature of environmental agent,, in human behavior in health and disease. (c) 2005 Elsevier SAS. All rights reserved.
C1 Univ Minnesota, Halberg Chronobiol Ctr, Minneapolis, MN 55455 USA.
Bowling Green State Univ, Bowling Green, OH 43403 USA.
Tokyo Womens Med Univ, Tokyo, Japan.
RP Halberg, F (reprint author), Univ Minnesota, Halberg Chronobiol Ctr, MMC 8609,420 Delaware St SE, Minneapolis, MN 55455 USA.
EM halbe001@umn.edu; corne001@umn.edu
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NR 66
TC 3
Z9 3
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI PARIS
PA 23 RUE LINOIS, 75724 PARIS, FRANCE
SN 0753-3322
J9 BIOMED PHARMACOTHER
JI Biomed. Pharmacother.
PD OCT
PY 2005
VL 59
SU 1
BP S100
EP S108
DI 10.1016/S0753-3322(05)80017-4
PG 9
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA 991HT
UT WOS:000233804000017
PM 16275478
ER
PT J
AU Bertone, A
Mottron, L
Jelenic, P
Faubert, J
AF Bertone, A
Mottron, L
Jelenic, P
Faubert, J
TI Enhanced and diminished visuo-spatial information processing in autism
depends on stimulus complexity
SO BRAIN
LA English
DT Review
DE autism, enhanced perceptual functioning; first and second order
information processing; lateral inhibition; neural networks; perception;
visuo-spatial information processing
ID COHERENT MOTION DETECTION; HIGH-FUNCTIONING PERSONS; HUMAN
VISUAL-SYSTEM; FRAGILE-X-SYNDROME; 2ND-ORDER MOTION; SPATIAL
INTEGRATION; HUMAN VISION; FORM VISION; CONTOUR INTEGRATION; CARTESIAN
GRATINGS
AB Visuo-perceptual processing in autism is characterized by intact or enhanced performance on static spatial tasks and inferior performance on dynamic tasks, suggesting a deficit of dorsal visual stream processing in autism. However, previous findings by Bertone et al. indicate that neuro-integrative mechanisms used to detect complex motion, rather than motion perception per se, may be impaired in autism. We present here the first demonstration of concurrent enhanced and decreased performance in autism on the same visuo-spatial static task, wherein the only factor dichotomizing performance was the neural complexity required to discriminate grating orientation. The ability of persons with autism was found to be superior for identifying the orientation of simple, luminance-defined (or first-order) gratings but inferior for complex, texture-defined (or second-order) gratings. Using a flicker contrast sensitivity task, we demonstrated that this finding is probably not due to abnormal information processing at a sub-cortical level (magnocellular and parvocellular functioning). Together, these findings are interpreted as a clear indication of altered low-level perceptual information processing in autism, and confirm that the deficits and assets observed in autistic visual perception are contingent on the complexity of the neural network required to process a given type of visual stimulus. We suggest that atypical neural connectivity, resulting in enhanced lateral inhibition, may account for both enhanced and decreased low-level information processing in autism.
C1 Univ Montreal, Ecole Optometrie, Visual Psychophys & Percept Lab, Montreal, PQ H3C 3J7, Canada.
Hop Riviere Prairies, Clin Specialisee Autisme, Montreal, PQ H1E 1A4, Canada.
RP Bertone, A (reprint author), Univ Montreal, Ecole Optometrie, Visual Psychophys & Percept Lab, 3744 Jean Brillant, Montreal, PQ H3T 1P1, Canada.
EM armando.bertone@umontreal.ca
RI Faubert, Jocelyn/E-2207-2011
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NR 122
TC 203
Z9 205
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0006-8950
J9 BRAIN
JI Brain
PD OCT
PY 2005
VL 128
BP 2430
EP 2441
DI 10.1093/brain/awh561
PN 10
PG 12
WC Clinical Neurology; Neurosciences
SC Neurosciences & Neurology
GA 970AW
UT WOS:000232278600021
PM 15958508
ER
PT J
AU O'Connor, K
Hamm, JP
Kirk, IJ
AF O'Connor, K
Hamm, JP
Kirk, IJ
TI The neurophysiological correlates of face processing in adults and
children with Asperger's syndrome
SO BRAIN AND COGNITION
LA English
DT Article
DE autism; Asperger's syndrome; face processing; ERPs; EEG
ID EVENT-RELATED POTENTIALS; AUTISM SPECTRUM DISORDER; FACIAL EXPRESSIONS;
BRAIN POTENTIALS; EMOTIONAL EXPRESSION; DEVELOPMENTAL DELAY;
YOUNG-CHILDREN; RECOGNITION; RESPONSES; HUMANS
AB Past research has found evidence for face and emotional expression processing differences between individuals with Asperger's syndrome (AS) and neurotypical (NT) controls at both the neurological and behavioural levels. The aim of the present study was to examine the neurophysiological basis of emotional expression processing in children and adults with AS relative to age- and gender-matched NT controls. High-density event-related potentials were recorded during explicit processing of happy, sad, angry, seared, and neutral faces. Adults with AS were found to exhibit delayed P1 and N170 latencies and smaller N170 amplitudes in comparison to control subjects for all expressions. This may reflect impaired holistic and configural processing of faces in AS adults. However, these differences were not observed between AS and control children. This may result from incomplete development of the neuronal generators of these ERP components and/or early intervention. (c) 2005 Elsevier Inc. All rights reserved.
C1 Univ Auckland, Dept Psychol, Res Ctr Cognit Neurosci, Auckland, New Zealand.
RP O'Connor, K (reprint author), Univ Auckland, Dept Psychol, Res Ctr Cognit Neurosci, Auckland, New Zealand.
EM koco016@ec.auckland.ac.nz
RI Hamm, Jeff/A-5911-2010
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NR 63
TC 53
Z9 55
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0278-2626
J9 BRAIN COGNITION
JI Brain Cogn.
PD OCT
PY 2005
VL 59
IS 1
BP 82
EP 95
DI 10.1016/j.bandc.2005.05.004
PG 14
WC Neurosciences; Psychology, Experimental
SC Neurosciences & Neurology; Psychology
GA 975RJ
UT WOS:000232679300009
PM 16009478
ER
PT J
AU Ming, X
Julu, POO
Brimacombe, M
Connor, S
Daniels, ML
AF Ming, X
Julu, POO
Brimacombe, M
Connor, S
Daniels, ML
TI Reduced cardiac parasympathetic activity in children with autism
SO BRAIN & DEVELOPMENT
LA English
DT Article
DE autism; brainstem; parasympathetic nerves; sympathetic nerves;
NeuroScope
ID AUTONOMIC RESPONSES; RETT-SYNDROME; BRAIN-STEM; DISORDERS; RECEPTOR;
STIMULI; BLOOD
AB Many of the clinical symptoms of autism suggest autonomic dysfunction. The aim of this study was to measure baseline cardiovascular autonomic function in children with autism using the NeuroScope, a device that can measure this brainstem function in real-time. Resting cardiac vagal tone (CVT), cardiac sensitivity to baroreflex (CSB), mean arterial blood pressure (MAP), diastolic blood pressure (DBP), systolic blood pressure (SBP) and heart rate (HR) were recorded in three different groups of children. The symptomatic group (n = 15) consisted of those with autism who exhibited symptoms or signs of autonomic dysfunction. The asymptomatic group (n = 13) consisted of children with autism but without symptoms or signs of autonomic dysfunction and the healthy children were in the control group (n = 117). The CVT and CSB were significantly lower in association with a significant elevation in HR, MAP and DBP in all children with autism compared with the healthy controls. Further more, the levels of CVT and CSB were lower in the symptomatic than in the asymptomatic group. The levels of CVT and CSB were not related to age in all the three groups. These results suggest that there is low baseline cardiac parasympathetic activity with evidence of elevated sympathetic tone in children with autism whether or not they have symptoms or signs of autonomic abnormalities. (c) 2005 Elsevier B.V. All rights reserved.
C1 Univ Med & Dent New Jersey, New Jersey Med Sch, Dept Neurosci, Newark, NJ 07103 USA.
Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Ctr Childhood Exposure & Assessment, Piscataway, NJ 08854 USA.
Cent Middlesex Hosp, Dept Neurol, Peripheral Nerve & Autonom Unit, London NW10 7NS, England.
Univ Med & Dent New Jersey, Sch Publ Hlth, Dept Prevent Med, Newark, NJ 07103 USA.
Kennedy Krieger Inst, Dept Neurol & Dev Med, Baltimore, MD 21205 USA.
RP Ming, X (reprint author), Univ Med & Dent New Jersey, New Jersey Med Sch, Dept Neurosci, 90 Bergen St,D0C 8100, Newark, NJ 07103 USA.
EM mingxu@umdnj.edu
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NR 38
TC 64
Z9 66
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0387-7604
J9 BRAIN DEV-JPN
JI Brain Dev.
PD OCT
PY 2005
VL 27
IS 7
BP 509
EP 516
DI 10.1016/j.braindev.2005.01.003
PG 8
WC Clinical Neurology
SC Neurosciences & Neurology
GA 977ZC
UT WOS:000232841000008
PM 16198209
ER
PT J
AU [Anonymous]
AF [Anonymous]
TI The genetics of autism
SO CELL BIOLOGY INTERNATIONAL
LA English
DT Meeting Abstract
NR 0
TC 0
Z9 0
PU ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 1065-6995
J9 CELL BIOL INT
JI Cell Biol. Int.
PD OCT
PY 2005
VL 29
IS 10
BP S26
EP S26
PG 1
WC Cell Biology
SC Cell Biology
GA 973FJ
UT WOS:000232508000110
ER
PT J
AU Skogstrand, K
Thorsen, P
Norgaard-Pedersen, B
Schendel, DE
Sorensen, LC
Hougaard, DM
AF Skogstrand, K
Thorsen, P
Norgaard-Pedersen, B
Schendel, DE
Sorensen, LC
Hougaard, DM
TI Simultaneous measurement of 25 inflammatory markers and neurotrophins in
neonatal dried blood spots by immunoassay with xMAP technology
SO CLINICAL CHEMISTRY
LA English
DT Article
ID FLOW-CYTOMETRIC ASSAYS; WHITE-MATTER LESIONS; CEREBRAL-PALSY; PRETERM
INFANTS; HUMAN CYTOKINES; PERIVENTRICULAR LEUKOMALACIA; CORD BLOOD;
SERUM; NEWBORN; INTERLEUKIN-6
AB Background: Inflammatory reactions and other events in early life may be part of the etiology of late-onset diseases, including cerebral palsy, autism, and type I diabetes. Most neonatal screening programs for congenital disorders are based on analysis of dried blood spot samples (DBSS), and stored residual DBSS constitute a valuable resource for research into the etiology of these diseases. The small amount of blood available, however, limits the number of analytes that can be determined by traditional immunoassay methodologies.
Methods: We used new multiplexed sandwich immunoassays based on flowmetric Luminex (R) xMAP technology to measure inflammatory markers and neutrophins in DBSS.
Results: The high-capacity 25-plex multianalyte method measured 23 inflammatory and trophic cytokines, triggering receptor expressed on myeloid cells-1 (TREM-1), and C-reactive. protein in two 3.2-mm punches from DBSS. It also measured 26 cytokines and TREM-1 in serum. Standards Recovery in the 25-plex method were 90%-161% (mean, 105%). The low end of the working range for all 25 analytes covered concentrations found in DBSS from healthy newborns. Mean recovery of exogenous analytes added at physiologic concentrations in DBSS models was 174%, mean intra- and interassay CVs were 6.2% and 16%, respectively, and the mean correlation between added and measured analytes was r(2) = 0.91. In DBSS routinely collected on days 5-7 from 8 newborns with documented inflammatory reactions at birth, the method detected significantly changed concentrations of inflammatory cytokines. Measurements on DBSS stored at -24 degrees C for > 20 years showed that most cytokines are detectable in equal concentrations over time.
Conclusions: The method can reliably measure 25 inflammatory markers and growth factors in DBSS. It has a large potential for high-capacity analysis of DBSS in epidemiologic case-control studies and, with further refinements, in neonatal screening. (c) 2005 American Association for Clinical Chemistry.
C1 Statens Serum Inst, Dept Clin Biochem, DK-2300 Copenhagen, Denmark.
Univ Aarhus, NANEA, Aarhus, Denmark.
Univ Aarhus, Dept Epidemiol & Social Med, Aarhus, Denmark.
Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabilities, Atlanta, GA USA.
Univ Copenhagen Hosp, Dept Pediat, Hvidovre, Denmark.
RP Hougaard, DM (reprint author), Statens Serum Inst, Dept Clin Biochem, Artillerivej 5, DK-2300 Copenhagen, Denmark.
EM dh@ssi.dk
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SN 0009-9147
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ID AUTISM SPECTRUM DISORDER; CLASSIFICATION; DOMAINS
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DT Review
DE episodic memory; hippocampus; contextual reinstatement
ID MULTIPLE PERSONALITY-DISORDER; PREFRONTAL CORTEX; HIPPOCAMPAL COMPLEX;
RETROGRADE-AMNESIA; PATH-INTEGRATION; EPISODIC MEMORY; SPATIAL MEMORY;
FRONTAL LOBES; LESIONS; MIND
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Univ Arizona, Dept Psychol, Tucson, AZ 85731 USA.
RP Samsonovich, AV (reprint author), George Mason Univ, Krasnow Inst Adv Study, 4400 Univ Dr,MS 2A1, Fairfax, VA 22030 USA.
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NR 112
TC 21
Z9 22
PU ELSEVIER MASSON
PI MILANO
PA VIA PALEOCAPA 7, 20121 MILANO, ITALY
SN 0010-9452
EI 1973-8102
J9 CORTEX
JI Cortex
PD OCT
PY 2005
VL 41
IS 5
BP 669
EP 689
DI 10.1016/S0010-9452(08)70284-3
PG 21
WC Behavioral Sciences; Neurosciences
SC Behavioral Sciences; Neurosciences & Neurology
GA 971DL
UT WOS:000232361400007
PM 16209330
ER
PT J
AU Kimmel, CA
Collman, GW
Fields, N
Eskenazi, B
AF Kimmel, CA
Collman, GW
Fields, N
Eskenazi, B
TI Lessons learned for the national children's study from the National
Institute of Environmental Health Sciences/US Environmental Protection
Agency Centers for Children's Environmental Health and Disease
Prevention Research
SO ENVIRONMENTAL HEALTH PERSPECTIVES
LA English
DT Article
DE asthma; autism; children; environmental health; National Children's
Study; NIEHS/EPA Children's Centers; obesity; pregnancy
ID PESTICIDE EXPOSURE; TOBACCO-SMOKE; POPULATION; BLOOD
AB This mini-monograph was developed to highlight the experiences of the National Institute of Environmental Health Sciences (NIEHS)/U.S. Environmental Protection Agency (EPA) Centers for Children's Environmental Health and Disease Prevention Research, focusing particularly on several areas of interest for the National Children's Study. These include general methodologic issues for conducting longitudinal birth cohort studies and community-based participatory research and for measuring air pollution exposures, pesticide exposures, asthma, and neuro-behavioral toxicity. Rather than a detailed description of the studies in each of the centers, this series of articles is intended to provide information on the practicalities of conducting such intensive studies and the lessons learned. This explication of lessons learned provides an outstanding opportunity for the planners of the National Children's Study to draw on past experiences that provide information on what has and has not worked when studying diverse multiracial and multi-ethnic groups of children with unique urban and rural exposures. The Children's Centers have addressed and overcome many hurdles in their efforts to understand the link between environmental exposures and health outcomes as well as interactions between exposures and a variety of social and cultural factors. Some of the major lessons learned include the critical importance of long-term studies for assessing the full range of developmental consequences of environmental exposures, recognition of the unique challenges presented at different life stages for both outcome and exposure measurement, and the importance of ethical issues that must be dealt with in a changing medical and legal environment. It is hoped that these articles will be of value to others who are embarking on studies of children's environmental health.
C1 NICHHD, Natl Childrens Study, US EPA, Bethesda, MD 20892 USA.
Natl Inst Environm Hlth Sci, Div Extramural Res & Training, Dept Hlth & Human Serv, NIH, Res Triangle Pk, NC USA.
US EPA, Natl Ctr Environm Res, Off Res & Dev, Washington, DC 20460 USA.
Univ Calif Berkeley, Sch Publ Hlth, Ctr Childrens Environm Hlth Res, Berkeley, CA 94720 USA.
RP Kimmel, CA (reprint author), NICHHD, Natl Childrens Study, US EPA, 3100 Execut Blve,Suite 5C01, Bethesda, MD 20892 USA.
EM kimmelca@mail.nih.gov
RI Reis, Aline/G-9573-2012
CR Berkowitz GS, 2004, ENVIRON HEALTH PERSP, V112, P388, DOI 10.1289/ehp.6414
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Eskenazi B, 2004, ENVIRON HEALTH PERSP, V112, P1116, DOI 10.1289/ehp.6789
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*USEPA, 2004, EPA600R04109
*USEPA, 2004, BIOM DAT
Walters DM, 2002, AM J RESP CELL MOL, V27, P413, DOI 10.1165/rcmb.4844
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NR 25
TC 11
Z9 11
PU US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE
PI RES TRIANGLE PK
PA NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, PO BOX 12233,
RES TRIANGLE PK, NC 27709-2233 USA
SN 0091-6765
J9 ENVIRON HEALTH PERSP
JI Environ. Health Perspect.
PD OCT
PY 2005
VL 113
IS 10
BP 1414
EP 1418
DI 10.1289/ehp.7669
PG 5
WC Environmental Sciences; Public, Environmental & Occupational Health;
Toxicology
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health; Toxicology
GA 970GF
UT WOS:000232292600052
PM 16203257
ER
PT J
AU Dietrich, KN
Eskenazi, B
Schantz, S
Yolton, K
Rauh, VA
Johnson, CB
Alkon, A
Canfield, RL
Pessah, IN
Berman, RF
AF Dietrich, KN
Eskenazi, B
Schantz, S
Yolton, K
Rauh, VA
Johnson, CB
Alkon, A
Canfield, RL
Pessah, IN
Berman, RF
TI Principles and practices of neurodevelopmental assessment in children:
Lessons learned from the Centers for Children's Environmental Health and
Disease Prevention Research
SO ENVIRONMENTAL HEALTH PERSPECTIVES
LA English
DT Review
DE behavior; development; National Children's Study; neurotoxicology; study
design
ID PORT PIRIE COHORT; PRENATAL PCB EXPOSURE; POLYCHLORINATED-BIPHENYLS;
IN-UTERO; DEVELOPMENTAL NEUROTOXICITY; BEHAVIORAL-DEVELOPMENT; PESTICIDE
EXPOSURE; CHELATION-THERAPY; LEAD-EXPOSURE; BLOOD LEAD
AB Principles and practices of pediatric neurotoxicology are reviewed here with the purpose of guiding the design and execution of the planned National Children's Study. The developing human central nervous system is the target organ most vulnerable to environmental chemicals. An investigation of the effects of environmental exposures on child development is a complex endeavor that requires consideration of numerous critical factors pertinent to a study's concept, design, and execution. These include the timing of neurodevelopmental assessment, matters of biologic plausibility, site, child and population factors, data quality assurance and control, the selection of appropriate domains and measures of neurobehavior, and data safety and monitoring. Here we summarize instruments for the assessment of the neonate, infant, and child that are being employed in the Centers for Children's Environmental Health and Disease Prevention Research, sponsored by the National Institute of Environmental Health Sciences and the U.S. Environmental Protection Agency, discuss neural and neurobiologic measures of development, and consider the promises of gene-environment studies. The vulnerability of the human central nervous system to environmental chemicals has been well established, but the contribution these exposures may make to problems such as attention deficit disorder, conduct problems, pervasive developmental disorder, or autism spectrum disorder remain uncertain. Large-scale studies such as the National Children's Study may provide some important clues. The human neurodevelopmental phenotype will be most clearly represented in models that include environmental chemical exposures, the social milieu, and complex human genetic characteristics that we are just beginning to understand.
C1 Univ Cincinnati, Coll Med, Dept Environm Hlth, Div Epidemiol & Biostat, Cincinnati, OH 45267 USA.
Cincinnati Childrens Environm Hlth Ctr, Cincinnati, OH USA.
Univ Calif Berkeley, Sch Publ Hlth, Ctr Childrens Environm Hlth Res, Berkeley, CA 94720 USA.
Univ Illinois, Friends Childrens Environm Hlth Ctr, Urbana, IL 61801 USA.
Univ Cincinnati, Coll Med, Childrens Environm Hlth Ctr, Cincinnati Childrens Hosp Med Ctr, Cincinnati, OH USA.
Columbia Univ, Columbia Ctr Childrens Environm Hlth, New York, NY USA.
Pediat Neuropsychol Grp, Berkeley, CA USA.
Univ Calif San Francisco, Sch Nursing, Dept Family Hlth Care Nursing, San Francisco, CA 94143 USA.
Cornell Univ, Coll Human Ecol, Div Nutr Sci, Ithaca, NY USA.
Univ Calif Davis, Dept Mol Biosci, Davis, CA 95616 USA.
Univ Calif Davis, Dept Neurol Surg, Davis, CA 95616 USA.
RP Dietrich, KN (reprint author), Univ Cincinnati, Coll Med, Dept Environm Hlth, Div Epidemiol & Biostat, 3223 Eden Ave, Cincinnati, OH 45267 USA.
EM Kim.Dietrich@uc.edu
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NR 105
TC 30
Z9 32
PU US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE
PI RES TRIANGLE PK
PA NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, PO BOX 12233,
RES TRIANGLE PK, NC 27709-2233 USA
SN 0091-6765
J9 ENVIRON HEALTH PERSP
JI Environ. Health Perspect.
PD OCT
PY 2005
VL 113
IS 10
BP 1437
EP 1446
DI 10.1289/ehp.7672
PG 10
WC Environmental Sciences; Public, Environmental & Occupational Health;
Toxicology
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health; Toxicology
GA 970GF
UT WOS:000232292600055
PM 16203260
ER
PT J
AU Bourgeron, T
AF Bourgeron, T
TI Genetic studies reveal atypical synaptic architectures in autism
spectrum disorders
SO EUROPEAN NEUROPSYCHOPHARMACOLOGY
LA English
DT Meeting Abstract
CT 18th ECNP Congress 2005
CY OCT 22-26, 2005
CL Amsterdam, NETHERLANDS
SP ECNP
C1 Inst Pasteur, Paris, France.
NR 0
TC 0
Z9 0
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0924-977X
J9 EUR NEUROPSYCHOPHARM
JI Eur. Neuropsychopharmacol.
PD OCT
PY 2005
VL 15
SU 3
BP S323
EP S324
PG 2
WC Clinical Neurology; Neurosciences; Pharmacology & Pharmacy; Psychiatry
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA 992CA
UT WOS:000233860600033
ER
PT J
AU Palmen, SJMC
Pol, HEH
Schmitz, C
Van Engeland, H
AF Palmen, SJMC
Pol, HEH
Schmitz, C
Van Engeland, H
TI Structural brain abnormalities in autism: neuroimaging and
neuropathology studies
SO EUROPEAN NEUROPSYCHOPHARMACOLOGY
LA English
DT Meeting Abstract
CT 18th ECNP Congress 2005
CY OCT 22-26, 2005
CL Amsterdam, NETHERLANDS
SP ECNP
C1 Univ Utrecht, Med Ctr, Dept Child Psychiat, Utrecht, Netherlands.
Univ Utrecht, Med Ctr, Dept Psychiat, Utrecht, Netherlands.
Univ Maastricht, Dept Psychiat & Neuropsychol, Maastricht, Netherlands.
NR 0
TC 0
Z9 0
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0924-977X
J9 EUR NEUROPSYCHOPHARM
JI Eur. Neuropsychopharmacol.
PD OCT
PY 2005
VL 15
SU 3
BP S323
EP S323
PG 1
WC Clinical Neurology; Neurosciences; Pharmacology & Pharmacy; Psychiatry
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA 992CA
UT WOS:000233860600032
ER
PT J
AU Pandina, G
Bouhours, P
Bossie, CA
Youssef, E
Zhu, Y
Dunbar, F
AF Pandina, G
Bouhours, P
Bossie, CA
Youssef, E
Zhu, Y
Dunbar, F
TI Symptomatic improvement demonstrated in children with autism treated
with risperidone
SO EUROPEAN NEUROPSYCHOPHARMACOLOGY
LA English
DT Meeting Abstract
CT 18th ECNP Congress 2005
CY OCT 22-26, 2005
CL Amsterdam, NETHERLANDS
SP ECNP
C1 Janssen Cilag, Med Affairs, Beervelde, France.
CR McCracken JT, 2002, NEW ENGL J MED, V347, P314, DOI 10.1056/NEJMoa013171
Shea S, 2004, PEDIATRICS, V114, pE634, DOI 10.1542/peds.2003-0264-F
NR 2
TC 0
Z9 0
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0924-977X
J9 EUR NEUROPSYCHOPHARM
JI Eur. Neuropsychopharmacol.
PD OCT
PY 2005
VL 15
SU 3
BP S631
EP S631
PG 1
WC Clinical Neurology; Neurosciences; Pharmacology & Pharmacy; Psychiatry
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA 992CA
UT WOS:000233860601325
ER
PT J
AU Scahill, L
AF Scahill, L
TI Risperidone in autism: findings from the research units on pediatric
psychopharmacology (RUPP) autism network
SO EUROPEAN NEUROPSYCHOPHARMACOLOGY
LA English
DT Meeting Abstract
CT 18th ECNP Congress 2005
CY OCT 22-26, 2005
CL Amsterdam, NETHERLANDS
SP ECNP
C1 Yale Univ, Ctr Child Study, New Haven, CT USA.
CR AMAN MG, IN PRESS AM J PSYCHI
McCracken JT, 2002, NEW ENGL J MED, V347, P314, DOI 10.1056/NEJMoa013171
NR 2
TC 0
Z9 0
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0924-977X
J9 EUR NEUROPSYCHOPHARM
JI Eur. Neuropsychopharmacol.
PD OCT
PY 2005
VL 15
SU 3
BP S324
EP S324
PG 1
WC Clinical Neurology; Neurosciences; Pharmacology & Pharmacy; Psychiatry
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA 992CA
UT WOS:000233860600034
ER
PT J
AU Zilbovicius, M
AF Zilbovicius, M
TI Functional brain imaging and autism
SO EUROPEAN NEUROPSYCHOPHARMACOLOGY
LA English
DT Meeting Abstract
CT 18th ECNP Congress 2005
CY OCT 22-26, 2005
CL Amsterdam, NETHERLANDS
SP ECNP
C1 SHFJ, Commissariat Energy Atom, Orsay, France.
NR 0
TC 0
Z9 0
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0924-977X
J9 EUR NEUROPSYCHOPHARM
JI Eur. Neuropsychopharmacol.
PD OCT
PY 2005
VL 15
SU 3
BP S323
EP S323
PG 1
WC Clinical Neurology; Neurosciences; Pharmacology & Pharmacy; Psychiatry
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA 992CA
UT WOS:000233860600030
ER
PT J
AU Spencer, CM
Alekseyenko, O
Serysheva, E
Yuva-Paylor, LA
Paylor, R
AF Spencer, CM
Alekseyenko, O
Serysheva, E
Yuva-Paylor, LA
Paylor, R
TI Altered anxiety-related and social behaviors in the Fmr1 knockout mouse
model of fragile X syndrome
SO GENES BRAIN AND BEHAVIOR
LA English
DT Article
DE autism; mirrored chamber; partition test; social anxiety; social
interaction; tube test
ID MENTAL-RETARDATION PROTEIN; MIRRORED CHAMBER; MESSENGER-RNAS; MICE;
MALES; IDENTIFICATION; DOMINANCE; FEATURES; STRAINS; ASSAY
AB The loss of fragile X mental retardation (FMR1) gene function causes fragile X syndrome (FXS), a common mental retardation syndrome. Anxiety and abnormal social behaviors are prominent features of FXS in humans. To better understand the role of FMR1 in these behaviors, we analyzed anxiety-related and social behaviors in Fmr1 knockout (KO) mice. In the mirrored chamber test, Fmr1 KO mice showed greater aversion to the central mirrored chamber than wild-type (WT) littermates, suggesting increased anxiety-like responses to reflected images of mice. Fmr1 KO mice exhibited abnormal social interactions in a tube test of social dominance, winning fewer matches than WT littermates. In a partition test, Fmr1 KO mice had normal levels of social interest and social recognition. However, during direct interaction tests, Fmr1 KO mice showed significant increases in sniffing behaviors. We further tested the influence of environmental familiarity on the social responses of Fmr1 KO mice to unfamiliar partners. In unfamiliar partitioned cages, Fmr1 KO mice did not differ from WT mice in investigation of unfamiliar partners. However, in familiar partitioned cages, Fmr1 KO mice showed less investigation of a newly introduced partner during the first 5 min and more investigation during the last 5 min of a 20-min partition test, behaviors consistent with initial social anxiety followed by enhanced social investigation. Our findings indicate that the loss of Fmr1 gene function results in altered anxiety and social behavior in mice and demonstrate that the Fmr1 KO mouse is a relevant animal model for the abnormal social responses seen in FXS.
C1 Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA.
Baylor Coll Med, Dept Neurosci, Houston, TX USA.
RP Paylor, R (reprint author), Baylor Coll Med, Dept Mol & Human Genet, 1 Baylor Plaza,436E, Houston, TX 77030 USA.
EM rpaylor@bcm.tmc.edu
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NR 43
TC 147
Z9 149
PU BLACKWELL PUBLISHING
PI OXFORD
PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND
SN 1601-1848
J9 GENES BRAIN BEHAV
JI Genes Brain Behav.
PD OCT
PY 2005
VL 4
IS 7
BP 420
EP 430
DI 10.1111/j.1601-183X.00123.x
PG 11
WC Behavioral Sciences; Neurosciences
SC Behavioral Sciences; Neurosciences & Neurology
GA 974IZ
UT WOS:000232586300003
PM 16176388
ER
PT J
AU Rendtorff, ND
Bjerregaard, B
Frodin, M
Kjaergaard, S
Hove, H
Skovby, F
Brondum-Nielsen, K
Schwartz, M
AF Rendtorff, ND
Bjerregaard, B
Frodin, M
Kjaergaard, S
Hove, H
Skovby, F
Brondum-Nielsen, K
Schwartz, M
CA Danish Tuberous Sclerosis Grp
TI Analysis of 65 tuberous sclerosis complex (TSC) patients by TSC2 DGGE,
TSC1/TSC2 MLPA, and TSC1 long-range PCR sequencing, and report of 28
novel mutations
SO HUMAN MUTATION
LA English
DT Article
DE TSC1; TSC2; DGGE; MLPA; mutation screening; Danish
ID PROTEIN TRUNCATION TEST; GRADIENT GEL-ELECTROPHORESIS; CARDIAC
RHABDOMYOMAS; GERMLINE MUTATIONS; UNRELATED PATIENTS; POINT MUTATIONS;
P53 GENE; TEST PTT; PHOSPHORYLATION; HAMARTIN
AB Tuberous sclerosis complex (TSC) is a severe autosomal dominant disorder characterized by the development of benign tumors (hamartomas) in many organs. It can lead to intellectual, handicap, epilepsy, autism, and renal or heart failure. An inactivating mutation in either of two tumor-suppressor genes-TSC1 and TSC2-is the cause of this syndrome, with TSC2 mutations accounting for 80-90% of all mutations. Molecular diagnosis of TSC is challenging, since TSC1 and TSC2 consist of 21 and 41 coding exons, respectively, and the mutation spectrum is very heterogeneous. Here we report a new approach for detecting mutations in TSC: a denaturing gradient gel electrophoresis (DGGE) analysis for small TSC2 mutations, a multiplex ligation-dependent probe amplification (MLPA) analysis for large deletions and duplications in TSC1 or TSC2, and a long-range PCR/sequencing based analysis for small TSC1 mutations. When applied in this order, the three methods provide a new sensitive and time, and cost-efficient strategy for the molecular diagnosis of TSC. We analyzed 65 Danish patients who had been clinically diagnosed with TSC, and identified pathogenic mutations in 51 patients (78%). These included 36 small TSC2 mutations, four large deletions involving TSC2, and 11 small TSC 1 mutations. Twenty-eight of the small mutations are novel. For the missense mutations, we established a functional assay to demonstrate that the mutations impair TSC2 protein function. In conclusion, the strategy presented may greatly help small- and medium-sized laboratories in the pre- and postnatal molecular diagnosis of TSC.
C1 Univ Copenhagen, Dept Med Biochem & Genet, Ctr Funct Genome Res, DK-2200 Copenhagen, Denmark.
John F Kennedy Inst, Dept Med Genet, Glostrup, Denmark.
Biotech Res & Innovat Ctr, Kinase Singalling Lab, Copenhagen, Denmark.
Rigshosp, Dept Clin Genet, Mol Genet Lab, Copenhagen, Denmark.
RP Rendtorff, ND (reprint author), Univ Copenhagen, Dept Med Biochem & Genet, Ctr Funct Genome Res, Blegdamsvej 3, DK-2200 Copenhagen, Denmark.
EM nanna@imbg.ku.dk
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NR 44
TC 13
Z9 16
PU WILEY-LISS
PI HOBOKEN
PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 1059-7794
J9 HUM MUTAT
JI Hum. Mutat.
PD OCT
PY 2005
VL 26
IS 4
BP 374
EP 383
DI 10.1002/humu.20227
PG 10
WC Genetics & Heredity
SC Genetics & Heredity
GA 966IY
UT WOS:000232014500012
PM 16114042
ER
PT J
AU Farmer, M
Oliver, A
AF Farmer, M
Oliver, A
TI Assesment of pragmatic difficulties and socio-emotional adjustment in
practice
SO INTERNATIONAL JOURNAL OF LANGUAGE & COMMUNICATION DISORDERS
LA English
DT Article
DE autistic spectrum disorders; pragmatic language difficulties;
socioemotional adjustment; assessment; Children's Communication
Checklist; Strengths and Difficulties Questionnaire
ID CHILDRENS COMMUNICATION CHECKLIST; AUTISTIC SPECTRUM DISORDERS;
PERVASIVE DEVELOPMENTAL DISORDERS; LANGUAGE IMPAIRMENT;
ASPERGER-SYNDROME; SOCIAL COGNITION; FOLLOW-UP; AGE; DEFICITS; MIND
AB Background: In professional practice, psychologists and other professionals such as therapists and teachers receive referrals of many children who present with social, emotional and behavioural difficulties that are difficult to understand and assess. The problems of some of these children may stem from pragmatic difficulties in communication. This paper reports the results of a study on the use of checklists in professional practice to assist in the identification of these difficulties.
Aims: (1) To ascertain whether two checklists, Bishop's (1998) Children's Communication Checklist and Goodman's (1997) Strengths and Difficulties Questionnaire, would discriminate between groups of children diagnosed as having autism, autistic spectrum disorder/Asperger's syndrome, pragmatic difficulties and children with other types of specific language impairment. (2) To investigate whether specific aspects of pragmatic difficulties can be identified as relating to difficulties in peer relationships. (3) To investigate whether ratings of pragmatic difficulties are related solely to difficulties in social relations or whether other aspects of socio-emotional adjustment are also affected.
Methods & Procedures: The Children's Communication Checklist and the Strengths and Difficulties Questionnaire were completed by the teachers and other professionals working with a sample of children (n=38) with a range of types of communication difficulty and being educated in schools run by one English Local Education Authority.
Outcomes & Results: Analyses of variance indicated that the scores for pragmatic competence and socio-emotional adjustment difficulties were useful in discriminating between groups of children with diagnoses of autism or autistic spectrum disorder, Asperger's syndrome, and other types of language impairment. No specific pragmatic correlates of social interactional difficulties were found, but ratings of hyperactivity were significantly correlated with pragmatic difficulties.
Conclusions: The two checklists if used together provide useful information on the profiles of strengths and weaknesses of children with a range of communication and or emotional/behavioural difficulties. The use of both checklists in this study demonstrated the differential profiles of pragmatic competence and socio-emotional adjustment of children with different types of communication difficulty.
C1 Northumbria Univ, Div Psychol, Newcastle Upon Tyne NE1 8ST, Tyne & Wear, England.
RP Farmer, M (reprint author), Northumbria Univ, Div Psychol, Northumberland Bldg, Newcastle Upon Tyne NE1 8ST, Tyne & Wear, England.
EM marion.farmer@unn.ac.uk
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NR 67
TC 8
Z9 8
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 1368-2822
J9 INT J LANG COMM DIS
JI Int. J. Lang. Commun. Disord.
PD OCT 1
PY 2005
VL 40
IS 4
BP 403
EP 429
DI 10.1080/13682820400027743
PG 27
WC Audiology & Speech-Language Pathology; Linguistics; Rehabilitation
SC Audiology & Speech-Language Pathology; Linguistics; Rehabilitation
GA 960CR
UT WOS:000231568300002
PM 16195198
ER
PT J
AU [Anonymous]
AF [Anonymous]
TI MMR autism link shattered
SO JOURNAL OF ADVANCED NURSING
LA English
DT News Item
NR 0
TC 0
Z9 0
PU BLACKWELL PUBLISHING
PI OXFORD
PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND
SN 0309-2402
J9 J ADV NURS
JI J. Adv. Nurs.
PD OCT
PY 2005
VL 52
IS 1
BP 105
EP 105
PG 1
WC Nursing
SC Nursing
GA 960BW
UT WOS:000231566200019
ER
PT J
AU Gena, A
Couloura, S
Kymissis, E
AF Gena, A
Couloura, S
Kymissis, E
TI Modifying the affective behavior of preschoolers with autism using
in-vivo or video modeling and reinforcement contingencies
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE autism; affective behavior; in-vivo modeling; observational learning;
video modeling
ID SOCIAL INTERACTIONS; TEACHING-CHILDREN; SKILLS; PEER; INTERVENTIONS;
MAINTENANCE; IMITATION; ACQUISITION; EXPRESSION; YOUTH
AB The purpose of this study was to modify the affective behavior of three preschoolers with autism in home settings and in the context of play activities, and to compare the effects of video modeling to the effects of in-vivo modeling in teaching these children contextually appropriate affective responses. A multiple-baseline design across subjects, with a return to baseline condition, was used to assess the effects of treatment that consisted of reinforcement, video modeling, in-vivo modeling, and prompting. During training trials, reinforcement in the form of verbal praise and tokens was delivered contingent upon appropriate affective responding. Error correction procedures differed for each treatment condition. In the in-vivo modeling condition, the therapist used modeling and verbal prompting. In the video modeling condition, video segments of a peer modeling the correct response and verbal prompting by the therapist were used as corrective procedures. Participants received treatment in three categories of affective behavior - sympathy, appreciation, and disapproval - and were presented with a total of 140 different scenarios. The study demonstrated that both treatments - video modeling and in-vivo modeling - systematically increased appropriate affective responding in all response categories for the three participants. Additionally, treatment effects generalized across responses to untrained scenarios, the child's mother, new therapists, and time.
C1 Univ Athens, Sch Philosophy, Dept Philosophy Educ & Psychol, GR-10679 Athens, Greece.
Athenian Ctr Child Dev & Educ, Athens, Greece.
Long Isl Univ, Dept Psychol, Greenvale, NY 11548 USA.
RP Gena, A (reprint author), Nikomedeias 66,Nea Smyrni, Athens 17124, Greece.
EM agena@ath.forthnet.gr
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NR 51
TC 43
Z9 43
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD OCT
PY 2005
VL 35
IS 5
BP 545
EP 556
DI 10.1007/s10803-005-0014-9
PG 12
WC Psychology, Developmental
SC Psychology
GA 992HU
UT WOS:000233875800001
PM 16163569
ER
PT J
AU Landa, RJ
Goldberg, MC
AF Landa, RJ
Goldberg, MC
TI Language, social, and executive functions in high functioning autism: A
continuum of performance
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE executive functions; autism; language; social; working memory;
flexibility
ID FRONTAL-LOBE EXCISIONS; PERVASIVE DEVELOPMENTAL DISORDERS; DIAGNOSTIC
OBSERVATION SCHEDULE; PREFRONTAL CORTEX DAMAGE; WORKING-MEMORY;
INFANTILE-AUTISM; AMYGDALO-HIPPOCAMPECTOMY; NEUROCOGNITIVE FUNCTION;
COMMUNICATION DEFICITS; JOINT ATTENTION
AB This study examined language and executive functions (EF) in high-functioning school-aged individuals with autism and individually matched controls. Relationships between executive, language, and social functioning were also examined. Participants with autism exhibited difficulty on measures of expressive grammar, figurative language, planning, and spatial working memory. A mixed profile of impaired and enhanced abilities was noted in set-shifting. While controls showed the typical increase in errors when shifting sets from an intra-dimensional to an extra-dimensional stimulus, this pattern was not noted in participants with autism. Relationships between EF, language, and social performance were weak to nonexistent. Implications for theories of core deficit in autism and dissociable nature of the language and executive impairments in autism are discussed.
C1 Johns Hopkins Sch Med, Baltimore, MD USA.
RP Landa, RJ (reprint author), Kennedy Krieger Inst, Ctr Autism & Related Disorders, 3901 Greenspring Ave, Baltimore, MD 21211 USA.
EM Landa@KennedyKrieger.org
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NR 79
TC 62
Z9 63
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD OCT
PY 2005
VL 35
IS 5
BP 557
EP 573
DI 10.1007/s10803-005-0001-1
PG 17
WC Psychology, Developmental
SC Psychology
GA 992HU
UT WOS:000233875800002
PM 16211332
ER
PT J
AU Bernier, R
Dawson, G
Panagiotides, H
Webb, S
AF Bernier, R
Dawson, G
Panagiotides, H
Webb, S
TI Individuals with autism spectrum disorder show normal responses to a
fear potential startle paradigm
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE autism spectrum disorders; amygdala; fear conditioning; potentiated
startle
ID POSTTRAUMATIC-STRESS-DISORDER; PERVASIVE DEVELOPMENTAL DISORDERS;
BILATERAL AMYGDALA DAMAGE; FACIAL EMOTION; DOUBLE DISSOCIATION; ANXIETY
DISORDERS; HUMANS; BRAIN; CHILDREN; RECOGNITION
AB The present study utilized a fear potentiated startle paradigm to examine amygdala function in individuals with autism spectrum disorder. Two competing hypotheses regarding amygdala dysfunction in autism have been proposed: (1) The amygdala is under-responsive, in which case it would be predicted that, in a fear potentiated startle experiment, individuals with autism would exhibit decreased fear conditioning and/or potentiation, and (2) The amygdala is over responsive, in which case an exaggerated potentiation of the startle response would be predicted. Fourteen adolescents and adults diagnosed with autism spectrum disorder and 14 age, gender, IQ, and anxiety level-matched typical adolescents and adults participated. Both participants with autism and typical participants potentiated the startle response following fear conditioning and no group differences in the latency or amplitude of the potentiated startle response were found. These results suggest that this aspect of amygdala function, namely fear conditioning and potentiation of the startle response, is intact in individuals with autism.
C1 Univ Washington, Ctr Human Dev & Disabil, Seattle, WA 98195 USA.
RP Bernier, R (reprint author), Univ Washington, Ctr Human Dev & Disabil, Box 357920, Seattle, WA 98195 USA.
EM rab2@u.washington.edu
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NR 59
TC 30
Z9 30
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD OCT
PY 2005
VL 35
IS 5
BP 575
EP 583
DI 10.1007/s10803-005-0002-0
PG 9
WC Psychology, Developmental
SC Psychology
GA 992HU
UT WOS:000233875800003
PM 16167091
ER
PT J
AU Ponnet, K
Buysse, A
Roeyers, H
De Corte, K
AF Ponnet, K
Buysse, A
Roeyers, H
De Corte, K
TI Empathic accuracy in adults with a pervasive developmental disorder
during an unstructured conversation with a typically developing stranger
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE autism; PDD; empathic accuracy; perspective-taking
ID HIGH-FUNCTIONING ADULTS; AUTISTIC-CHILDREN; ASPERGER-SYNDROME; MIND;
ADOLESCENTS; COGNITION; BEHAVIOR; SEX
AB The present paper consists of two parts. In the first part, eleven high-functioning adults with pervasive developmental disorder (PDD) participated and were videotaped with a concealed camera while having an initial conversation with a typically developing stranger. Analyses revealed some significant differences with regard to the dyad members' overt behaviours. Contrary to our main hypothesis, analyses of the covert behaviour revealed that the participants with PDD did not differ from the typically developing participants in the ability to infer the thoughts and feelings of their interaction partner. The second part indicated that the inference ability of both groups was independent of the dyad members' behavioural characteristics and the content of the dyad members' thoughts and feelings. Issues addressed in this paper include the relation of scriptal knowledge to social functioning, and the advantage participants with PDD take from more structured interactions compared with less structured interactions.
C1 State Univ Ghent, Res Grp Dev Disorders, Dept Psychol, B-9000 Ghent, Belgium.
RP Buysse, A (reprint author), State Univ Ghent, Res Grp Dev Disorders, Dept Psychol, Henri Dunantlaan 2, B-9000 Ghent, Belgium.
EM Ann.Buysse@UGent.be
CR American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th
Attwood T., 1998, ASPERGERS SYNDROME G
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NR 39
TC 11
Z9 11
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD OCT
PY 2005
VL 35
IS 5
BP 585
EP 600
DI 10.1007/s10803-005-0003-z
PG 16
WC Psychology, Developmental
SC Psychology
GA 992HU
UT WOS:000233875800004
PM 16167090
ER
PT J
AU Reed, P
Gibson, E
AF Reed, P
Gibson, E
TI The effect of concurrent task load on stimulus over-selectivity
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article; Proceedings Paper
CT Annual Conference of the Association-for-Behavior-Analysis
CY 2001
CL Venice, ITALY
SP Assoc Behav Analy
DE autism overselectivity; delayed-matching-to-sample; memory; humans
ID MULTIPLE VISUAL CUES; AUTISTIC-CHILDREN; SCHIZOPHRENIC CHILDREN; LATENT
INHIBITION; WORKING-MEMORY; OVERSELECTIVITY; ATTENTION; RESPONSES;
INTACT; MODELS
AB Stimulus over-selectivity is a phenomenon displayed by individuals with autism, and has been implicated as a basis for many autistic-spectrum symptoms. In four experiments, non-autistic adult participants were required to learn a simple discrimination using picture cards. and then were tested for the emergence of stimulus over-selectivity, both with and without a concurrent task. Greater stimulus over-selectivity was noted when participants completed the concurrent task. The results are discussed in relation to the implications for the development of a model of memory deficits in autism.
C1 Univ Coll Swansea, Dept Psychol, Swansea SA2 8PP, W Glam, Wales.
Univ London St Georges Hosp, London SA2 8PP, England.
RP Reed, P (reprint author), Univ Coll Swansea, Dept Psychol, Singleton Pk, Swansea SA2 8PP, W Glam, Wales.
EM p.reed@swansea.ac.uk
CR BADDELEY A, 1992, Q J EXP PSYCHOL-A, V44, P1
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NR 34
TC 25
Z9 25
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD OCT
PY 2005
VL 35
IS 5
BP 601
EP 614
DI 10.1007/s10803-005-0004-y
PG 14
WC Psychology, Developmental
SC Psychology
GA 992HU
UT WOS:000233875800005
PM 16172811
ER
PT J
AU Hoksbergen, R
ter Laak, J
Rijk, K
van Dijkum, C
Stoutjesdijk, F
AF Hoksbergen, R
ter Laak, J
Rijk, K
van Dijkum, C
Stoutjesdijk, F
TI Post-institutional autistic syndrome in Romanian adoptees
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE autism; adoption; Romania; institutionalized; research
ID EARLY SEVERE DEPRIVATION; CHILDREN; ATTACHMENT; DISTURBANCES;
ADJUSTMENT; DISORDERS
AB Romanian adoptees have a background of severe neglect. International research has shown that this can give rise to symptoms of autistic behavior. Rutter et al. (1999, Journal of Child Psychology Psychiatry, 40(4), 537-549.) refers to "quasi-autistic patterns", and Federici (1998, Help for the hopelss child: A guide for families. Alexandria: Federici & Assocoates.) to Post-Institutional Autistic Syndrome (PIAS). Eighty Romanian adoptees, averaging 8 years of age, who had resided in the Netherlands for 5 years were studied. Parent interviews and the Auti-R scale showed the extent to which the children exhibited PIAS. In one third of these children we observed (in addition to other behavioral problems) stereotypic behaviors and communication and language disorders. Our findings resembled the Rutter et al. (1999, Journal of Child Psychology Psychiatry, 40(4), 537-549). data. Six of the children were classified within the autistic spectrum pursuant to the Auti-R, and seven within the so-called intermediate group. No difference was found between the girls and the boys. Children who had been in their adoptive families for 5 years or more showed fewer behavior problems than children who had been in their adoptive families for four or less years.
C1 Univ Utrecht, Adopt Dept, Fac Social Sci, NL-3584 CS Utrecht, Netherlands.
Romanian Childrens Home Trandafir Din Saron, Utrecht, Netherlands.
RP Hoksbergen, R (reprint author), Univ Utrecht, Dept Adopt & Nongenet Parenthood, Heidelberglaan 2, NL-3584 CS Utrecht, Netherlands.
EM R.Hoksbergen@fss.uu.nl
RI Rijk, Catharina/H-6404-2013
CR Achenbach T. M., 1983, MANUAL CHILD BEHAV C
American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th
Ames E. W., 1997, DEV ROMANIAN ORPHANA
Bowlby John, 1971, ATTACHMENT LOSS, V1
Bowlby John, 1946, 44 JUVENILE THIEVES
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NR 45
TC 20
Z9 20
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD OCT
PY 2005
VL 35
IS 5
BP 615
EP 623
DI 10.1007/s10803-005-0005-x
PG 9
WC Psychology, Developmental
SC Psychology
GA 992HU
UT WOS:000233875800006
PM 16167089
ER
PT J
AU Perry, A
Condillac, RA
Freeman, NL
Dunn-Geier, J
Belair, J
AF Perry, A
Condillac, RA
Freeman, NL
Dunn-Geier, J
Belair, J
TI Multi-site study of the childhood autism rating scale (CARS) in five
clinical groups of young children
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article; Proceedings Paper
CT Annual Convention of the Canadian-Psychological-Association
CY JUN, 2000
CL OTTAWA, CANADA
SP Canadian Psychol Assoc
DE CARS; diagnosis; assessment; autism; PDD-NOS; MR
ID RELIABILITY; ADOLESCENTS; DISORDERS; DIAGNOSIS; VALIDITY
AB This study examined several questions pertaining to the Childhood Autism Rating Scale (CARS) in a sample of 274 preschool children (aged 2-6 years) clinically diagnosed as falling in one of five groups: Autistic Disorder, PDD-NOS, MR, Delayed, and Other. In addition to diagnosis and the CARS, all children were given standardized cognitive and adaptive behavior measures. Results indicated high concordance between the CARS and clinical diagnosis using DSM-IV (including excellent sensitivity and specificity). There was a moderate negative correlation of CARS scores and developmental level (both cognitive and adaptive), indicating significant shared variance. There were significant and sensible differences in mean CARS score for different diagnostic groups, including a substantial difference between the Autistic Disorder and PDD-NOS groups.
C1 York Univ, ClinDev Psychol Program, Toronto, ON M3J 1P3, Canada.
TRE ADD, Thistletown Reg Ctr, Toronto, ON, Canada.
Surrey Pl Ctr, Toronto Presch Autism Serv, Toronto, ON M5S 2C2, Canada.
Child Dev Serv, Ottawa, ON, Canada.
Eastern Reg Presch Autism Program, Ottawa, ON, Canada.
RP Perry, A (reprint author), York Univ, ClinDev Psychol Program, 4700 Keele St,BSB 219, Toronto, ON M3J 1P3, Canada.
EM perry@yorku.ca
CR ALPERN G, 1980, DEV PROFILE 2
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NR 34
TC 51
Z9 52
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD OCT
PY 2005
VL 35
IS 5
BP 625
EP 634
DI 10.1007/s10803-005-0006-9
PG 10
WC Psychology, Developmental
SC Psychology
GA 992HU
UT WOS:000233875800007
PM 16172810
ER
PT J
AU Hastings, RP
Kovshoff, H
Ward, NJ
Espinosa, FD
Brown, T
Remington, B
AF Hastings, RP
Kovshoff, H
Ward, NJ
Espinosa, FD
Brown, T
Remington, B
TI Systems analysis of stress and positive perceptions in mothers and
fathers of pre-school children with autism
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE autism; mothers; fathers; stress; positive perceptions pre-school
children; families
ID DEVELOPMENTAL BEHAVIOR CHECKLIST; MENTAL-RETARDATION; FAMILY STRESS;
DOWN-SYNDROME; PSYCHOLOGICAL ADJUSTMENT; INTELLECTUAL DISABILITY;
PSYCHOMETRIC PROPERTIES; PARENTING STRESS; YOUNG-CHILDREN; RESPITE CARE
AB Systemic analyses of psychological functioning in families of children with autism have typically shown that parents report different experiences (e.g., stress) and that siblings may also be affected. The purpose of the present research was more explicitly to address relationships between child, partner, and parent variables. Parents of 48 children with autism (41 mother-father pairs) reported on child characteristics, and their own stress and mental health. Mothers were found to report both more depression and more positive perceptions than fathers. Regression analyses revealed that paternal stress and positive perceptions were predicted by maternal depression; maternal stress was predicted by their children's behavior problems (not adaptive behavior or autism symptoms) and by their partner's depression. The future testing of the mechanisms underlying these results is discussed. In addition, the need is emphasized for more systemic analyses to understand the psychological functioning of children with autism and their siblings and parents.
C1 Univ Wales, Sch Psychol, Bangor LL57 2DG, Gwynedd, Wales.
Univ Southampton, Sch Psychol, Ctr Behav Res Anal & Intervent Dev Disabil, Southampton SO9 5NH, Hants, England.
RP Hastings, RP (reprint author), Univ Wales, Sch Psychol, Bangor LL57 2DG, Gwynedd, Wales.
EM nhastings@bangor.ac.uk
RI Hastings, Richard/D-9657-2013
OI Hastings, Richard/0000-0002-0495-8270
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NR 51
TC 138
Z9 141
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD OCT
PY 2005
VL 35
IS 5
BP 635
EP 644
DI 10.1007/s10803-005-0007-8
PG 10
WC Psychology, Developmental
SC Psychology
GA 992HU
UT WOS:000233875800008
PM 16177837
ER
PT J
AU Baranek, GT
Danko, CD
Skinner, ML
Bailey, DB
Hatton, DD
Roberts, JE
Mirrett, PL
AF Baranek, GT
Danko, CD
Skinner, ML
Bailey, DB
Hatton, DD
Roberts, JE
Mirrett, PL
TI Video analysis of sensory-motor features in infants with fragile X
syndrome at 9-12 months of age
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE home movies; mental retardation; fragile X syndrome (FXS); autism;
sensorimotor development; infancy
ID DEVELOPMENTAL TRAJECTORIES; AUTISTIC BEHAVIOR; YOUNG-CHILDREN; MALES;
PREVALENCE; PHENOTYPE; SYMPTOMS; BOYS
AB This study utilized retrospective video analysis to distinguish sensory-motor patterns in infants with fragile X syndrome (FXS) (n = 11) from other infants [i.e., autism (n = 11), other developmental delay (n = 10), typical (n = 11)] at 9-12 months of age. Measures of development, autistic features, and FMRP were assessed at the time of entry into the study. Home videos collected from families were edited and coded with previously validated procedures. Findings revealed a pattern of sensory-motor features (e.g., repetitive leg movements, posturing, less sophistication/repetitive use of objects) associated with FXS, and suggest these infants were most similar to the group of infants with other developmental delays, irrespective of co-existing autistic symptoms later in life. Infant sensory-motor features in the FXS group were more predictive of an early developmental milestone (i.e., age walking) than later, more broad, developmental outcomes, or FMRP. Implications for early identification and differential diagnosis are discussed.
C1 Univ N Carolina, Div Occupat Sci, Dept Allied Hlth Sci, UNC CH, Chapel Hill, NC 27599 USA.
RP Baranek, GT (reprint author), Univ N Carolina, Div Occupat Sci, Dept Allied Hlth Sci, UNC CH, CB 7120, Chapel Hill, NC 27599 USA.
EM gbaranek@med.unc.edu
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NR 33
TC 28
Z9 28
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD OCT
PY 2005
VL 35
IS 5
BP 645
EP 656
DI 10.1007/s10803-005-008-7
PG 12
WC Psychology, Developmental
SC Psychology
GA 992HU
UT WOS:000233875800009
PM 16172809
ER
PT J
AU Goldberg, WA
Jarvis, KL
Osann, K
Laulhere, TM
Straub, C
Thomas, E
Filipek, P
Spence, MA
AF Goldberg, WA
Jarvis, KL
Osann, K
Laulhere, TM
Straub, C
Thomas, E
Filipek, P
Spence, MA
TI Brief report: Early social communication behaviors in the younger
siblings of children with autism
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article; Proceedings Paper
CT Annual Meeting of the Western-Psychological-Association
CY APR, 2002
CL Irvine, CA
SP Western Psychol Assoc
DE autism; siblings; social; communication; joint attention
ID JOINT ATTENTION; DISORDER; INDIVIDUALS; PHENOTYPE; TWIN
AB The early social and communicative development of very young siblings of children with autism spectrum disorder (ASD) is the focus of the current study. Three groups of children were included: (1) young children diagnosed with ASD, (2) younger siblings in families with a somewhat older child with ASD, and (3) young typically developing children. All children participated in a videotaped, structured interactional procedure called the Early Social Communication Scales (ESCS; [Mundy & Hogan, 1996, A Preliminary Manual for the Abridged Early Social Communication Scales (ESCS) Unpublished manual, University of Miami]). Very young siblings were compared to young children with a diagnosed autism spectrum disorder and to a group of young typically developing children. Results indicated that, on three of four of the ESCS subscales, the social communicative behaviors of the younger siblings differed from those of the typically developing children but not from the behaviors displayed by the ASD group. Genetic vulnerability for ASD among siblings and characteristics of family interaction may explain the level of impairment observed in the very young siblings of children with autism spectrum disorders.
C1 Univ Calif Irvine, Dept Psychol & Social Behav, Irvine, CA 92697 USA.
Univ Calif Irvine, Med Ctr, Dept Med, Irvine, CA 92717 USA.
Univ Calif Irvine, Med Ctr, Dept Pediat, Irvine, CA 92717 USA.
RP Goldberg, WA (reprint author), Univ Calif Irvine, Dept Psychol & Social Behav, 3375 SE 2, Irvine, CA 92697 USA.
EM wagoldbe@uci.edu
CR *AM AC NEUR, 2000, PRACT PAR SCREEN DIA, P468
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NR 34
TC 32
Z9 32
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD OCT
PY 2005
VL 35
IS 5
BP 657
EP 664
DI 10.1007/s10803-005-0009-6
PG 8
WC Psychology, Developmental
SC Psychology
GA 992HU
UT WOS:000233875800010
PM 16167088
ER
PT J
AU Starr, EM
Berument, SK
Tomlins, M
Papanikolaou, K
Rutter, M
AF Starr, EM
Berument, SK
Tomlins, M
Papanikolaou, K
Rutter, M
TI Brief report: Autism in individuals with Down syndrome
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE autism; Down syndrome; severe mental retardation
ID DIAGNOSTIC OBSERVATION SCHEDULE; PERVASIVE DEVELOPMENTAL DISORDERS;
PSYCHIATRIC-DISORDERS; INFANTILE-AUTISM; CHILDREN; ABNORMALITIES;
SPECTRUM; BEHAVIOR
AB As an off-shoot of a study examining the reliability and validity of an adapted version of the Pre-Linguistic Autism Diagnostic Observation Schedule (A-PL-ADOS), 13 individuals with Down syndrome with IQs ranging between 24 and 48 were administered the Autism Diagnostic Interview-Revised (ADI-R) and the A-PL-ADOS, which are well-validated interview and observational diagnostic measures. Three out of 13 met lifetime criteria on the ADI-R, but none of these three showed behavior that met the criterion for autism on the APL-ADOS (although two nearly did so). However, two individuals did meet the A-PL-ADOS criterion and showed behavior that fell only just short of meeting lifetime criteria on the ADI-R. Altogether, 5 individuals with Down syndrome may be considered to show an autism spectrum disorder. Of the remaining 8, some showed a few autistic features, and some showed none. The findings raise both methodological and conceptual issues.
C1 Univ London, MRC, Child Psychiat Unit, London WC1E 7HU, England.
RP Starr, EM (reprint author), Univ Windsor, Fac Educ, Windsor, ON N9B 3P4, Canada.
EM estarr@uwindsor.ca
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NR 37
TC 19
Z9 19
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD OCT
PY 2005
VL 35
IS 5
BP 665
EP 673
DI 10.1007/s10803-005-0010-0
PG 9
WC Psychology, Developmental
SC Psychology
GA 992HU
UT WOS:000233875800011
PM 16167094
ER
PT J
AU Talebizadeh, Z
Bittel, DC
Veatch, OJ
Kibiryeva, N
Butler, MG
AF Talebizadeh, Z
Bittel, DC
Veatch, OJ
Kibiryeva, N
Butler, MG
TI Brief report: Non-random X chromosome inactivation in females with
autism
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE autism; X inactivation; females; AGRE
ID PERVASIVE DEVELOPMENTAL DISORDERS; XIST GENE; CARRIERS; METHYLATION;
FAMILIES; MUTATION; REPEATS; DISEASE; REGION; COMMON
AB Autism is a heterogeneous neurodevelopmental disorder with a 3-4 times higher sex ratio in males than females. X chromosome genes may contribute to this higher sex ratio through unusual skewing of X chromosome inactivation. We studied X chromosome skewness in 30 females with classical autism and 35 similarly aged unaffected female siblings as controls using the polymorphic androgen receptor (AR) gene. Significantly, increased X chromosome skewness (e.g., > 80:20%) was detected in our autism group (33%) compared to unaffected females (11%). X chromosome skewness was also seen in 50% of the mothers with autistic daughters. No mutation was seen in the promoter region of the XIST gene reported to be involved in X chromosome inactivation in our subjects. X chromosome skewness has been reported in female carriers of other neurological disorders such as X-linked mental retardation, adrenoleukodystrophy and Rett syndrome.
C1 Univ Missouri, Kansas City Sch Med, Sect Med Genet & Mol Med, Childrens Mercy Hosp & Clin, Kansas City, MO 64108 USA.
RP Butler, MG (reprint author), Univ Missouri, Kansas City Sch Med, Sect Med Genet & Mol Med, Childrens Mercy Hosp & Clin, 2401 Gillham Rd, Kansas City, MO 64108 USA.
EM mgbutler@cmh.edu
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NR 30
TC 29
Z9 30
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD OCT
PY 2005
VL 35
IS 5
BP 675
EP 681
DI 10.1007/s10803-005-0011-z
PG 7
WC Psychology, Developmental
SC Psychology
GA 992HU
UT WOS:000233875800012
PM 16167093
ER
PT J
AU Lyons, V
Fitzgerald, M
AF Lyons, V
Fitzgerald, M
TI Early memory and autism
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Letter
ID SAVANT
C1 Trinity Coll Dublin, Dublin, Ireland.
RP Lyons, V (reprint author), Trinity Coll Dublin, Dublin, Ireland.
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NR 9
TC 3
Z9 3
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD OCT
PY 2005
VL 35
IS 5
BP 683
EP 683
DI 10.1007/s10803-005-0012-y
PG 1
WC Psychology, Developmental
SC Psychology
GA 992HU
UT WOS:000233875800013
PM 16175314
ER
PT J
AU Jayachandra, S
AF Jayachandra, S
TI Need for internet based scoring system for autism treatment evaluation
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Letter
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
NR 1
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD OCT
PY 2005
VL 35
IS 5
BP 684
EP 684
PG 1
WC Psychology, Developmental
SC Psychology
GA 992HU
UT WOS:000233875800014
PM 16184339
ER
PT J
AU Wu, JY
Kuban, KCK
Allred, E
Shapiro, F
Darras, BT
AF Wu, JY
Kuban, KCK
Allred, E
Shapiro, F
Darras, BT
TI Association of Duchenne muscular dystrophy with autism spectrum disorder
SO JOURNAL OF CHILD NEUROLOGY
LA English
DT Article
ID COGNITIVE IMPAIRMENT; INTELLECTUAL IMPAIRMENT; MENTAL-RETARDATION;
GENE-PRODUCT; MUSCLE; BRAIN; EPIDEMIOLOGY; DELETIONS; CELL; DEFICIENCY
AB We hypothesize that Duchenne muscular dystrophy and autism spectrum disorder/pervasive developmental disorder co-occur with a greater than random frequency. In this study, we set out to reject the hypothesis that Duchenne muscular dystrophy and autism spectrum disorder/pervasive developmental disorder co-occur no more often than expected by chance. Two index cases and six additional boys with concomitant Duchenne muscular dystrophy and autism spectrum disorder were identified in a muscular dystrophy clinic that approximates the total number of Duchenne muscular dystrophy boys (158) in the state of Massachusetts. The rate of prevalence (6 of 158) was compared with the prevalence rate of autism spectrum disorder in boys in the general population (1.6 in 1000). We rejected the hypothesis that Duchenne muscular dystrophy and autism spectrum disorder co-occurrence was likely to be explained by chance (P =.006). We identify a previously unrecognized association of Duchenne muscular dystrophy with autism spectrum disorder. Further work might elucidate the level of association between these two conditions, either at the genetic or at the protein level, and might clarify, at least partially, the neurobiologic mechanisms associated with autism spectrum disorder.
C1 Harvard Univ, Sch Med, Dept Neurol, Div Neuroepidemiol, Boston, MA 02115 USA.
Harvard Univ, Childrens Hosp Boston, Sch Publ Hlth, Dept Neurol, Boston, MA 02115 USA.
Childrens Hosp, Neuromuscular Program, Boston, MA 02115 USA.
Harvard Univ, Sch Med, Dept Neurol, Boston, MA 02115 USA.
Harvard Univ, Sch Med, Dept Orthoped, Boston, MA 02115 USA.
Univ Calif Los Angeles, Mattel Childrens Hosp, David Geffen Sch Med, Div Pediat Neurol, Los Angeles, CA USA.
Boston Univ, Sch Med, Div Pediat Neurol, Boston, MA 02215 USA.
RP Darras, BT (reprint author), Harvard Univ, Sch Med, Dept Neurol, Div Neuroepidemiol, Fegan 11,300 Longwood Ave, Boston, MA 02115 USA.
EM basil.darras@childrens.harvard.edu
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NR 46
TC 45
Z9 46
PU B C DECKER INC
PI HAMILTON
PA 20 HUGHSON ST SOUTH, PO BOX 620, L C D 1, HAMILTON, ONTARIO L8N 3K7,
CANADA
SN 0883-0738
J9 J CHILD NEUROL
JI J. Child Neurol.
PD OCT
PY 2005
VL 20
IS 10
BP 790
EP 795
DI 10.1177/08830738050200100201
PG 6
WC Clinical Neurology; Pediatrics
SC Neurosciences & Neurology; Pediatrics
GA 004BR
UT WOS:000234727500002
PM 16417872
ER
PT J
AU Doherty, C
Goh, S
Poussaint, TY
Erdag, N
Thiele, EA
AF Doherty, C
Goh, S
Poussaint, TY
Erdag, N
Thiele, EA
TI Prognostic significance of tuber count and location in tuberous
sclerosis complex
SO JOURNAL OF CHILD NEUROLOGY
LA English
DT Article
ID SEVERITY; AUTISM; EPILEPSY
AB The objectives of this study were (1) to test the utility of tuber count and tuber location as biomarkers of disease severity in patients with tuberous sclerosis complex and (2) to examine the relationship between gene mutation, tuber count, and tuber location. We found that an increased tuber count per lobe and in total was associated with an increased risk of infantile spasms (P <. 0 1). Increased tuber count in the occipital lobe was associated with an increased risk of pervasive developmental disorder (P =.0074). The mean tuber count per lobe and in total was higher in those with poorly controlled seizures and those with off-track development; however, these differences were not statistically significant (P >.01). The TSC2 gene mutation was associated with a significant increase in the tuber count per lobe and in total (P <.0 1). In summary, increased tuber count is strongly associated with infantile spasms and a TSC2 gene mutation. Seizure control and developmental delay do not show the strong association with tuber count suggested by the earlier literature.
C1 Massachusetts Gen Hosp, Dept Neurol, Boston, MA 02114 USA.
Childrens Hosp, Dept Radiol, Boston, MA 02115 USA.
RP Thiele, EA (reprint author), Massachusetts Gen Hosp, Dept Neurol, 55 Fruit St,VBK 830, Boston, MA 02114 USA.
EM ethiele@partners.org
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NR 24
TC 31
Z9 32
PU B C DECKER INC
PI HAMILTON
PA 20 HUGHSON ST SOUTH, PO BOX 620, L C D 1, HAMILTON, ONTARIO L8N 3K7,
CANADA
SN 0883-0738
J9 J CHILD NEUROL
JI J. Child Neurol.
PD OCT
PY 2005
VL 20
IS 10
BP 837
EP 841
DI 10.1177/08830738050200101301
PG 5
WC Clinical Neurology; Pediatrics
SC Neurosciences & Neurology; Pediatrics
GA 004BR
UT WOS:000234727500013
PM 16417883
ER
PT J
AU Milner, KM
Craig, EE
Thompson, RJ
Veltman, MWM
Thomas, NS
Roberts, S
Bellamy, M
Curran, SR
Sporikou, CMJ
Bolton, PF
AF Milner, KM
Craig, EE
Thompson, RJ
Veltman, MWM
Thomas, NS
Roberts, S
Bellamy, M
Curran, SR
Sporikou, CMJ
Bolton, PF
TI Prader-Willi syndrome: intellectual abilities and behavioural features
by genetic subtype
SO JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY
LA English
DT Article
DE Prader-Willi syndrome; genotype; genetics; autism; obsessions;
compulsions; uniparental disomy; imprinting; chromosome 15
ID MATERNAL UNIPARENTAL DISOMY; OBSESSIVE-COMPULSIVE SCALE;
ANGELMAN-SYNDROME GENE; PROXIMAL 15Q; DELETION; AUTISM; SPECTRUM;
RELIABILITY; DISORDERS; PHENOTYPE
AB Background: Studies of chromosome 15 abnormality have implicated over-expression of paternally imprinted genes in the 15q11-13 region in the aetiology of autism. To test this hypothesis we compared individuals with Prader-Willi syndrome (PWS) due to uniparental disomy (UPD - where paternally imprinted genes are over-expressed) to individuals with the 15q11-13 deletion form of the syndrome ( where paternally imprinted genes are not over-expressed). We also tested reports that PWS cases due to the larger type I (TI) form of deletion show differences to cases with the smaller type II (TII) deletion. Method: Ninety-six individuals with PWS were recruited from genetic centres and the PWS association. Forty-nine individuals were confirmed as having maternal UPD of chromosome 15 and were age and sex matched to 47 individuals with a deletion involving 15q11-13 ( 32 had the shorter ( T II) deletion, and 14 had the longer ( TI) deletion). Behavioural assessments were carried out blind to genetic status, using the Autism Diagnostic Observation Schedule (ADOS), the Autism Diagnostic Interview (ADI),the Autism Screening Questionnaire (ASQ), the Children's Yale-Brown Obsessive-Compulsive Scale (CY-BOCS),the Vineland Adaptive Behaviour Scales (VABS), and measurements of intellectual ability, including the Wechsler and Mullen Scales and Raven's Matrices. Results: UPD cases exhibited significantly more autistic-like impairments in reciprocal social interaction on questionnaire, interview and standardised observational measures. Comparison of TI and TII deletion cases revealed few differences, but ability levels tended to be lower in the TI deletion cases. Conclusions: Findings from a large study comparing deletion and UPD forms of Prader-Willi syndrome were consistent with other evidence in indicating that paternally imprinted genes in the 15q11-13 region constitute a genetic risk factor for aspects of autistic symptomatology. These genes may therefore play a role in the aetiology of autism. By contrast with another report, there was no clear-cut relationship between the size of the deletion and the form of cognitive and behavioural phenotype.
C1 Inst Psychiat PO46, Child Adolescent Psychiat Dept, London SE4 8AF, England.
Inst Psychiat PO46, MRC, Social Genet & Dev Psychiat Ctr, London SE4 8AF, England.
Wessex Reg Genet Lab, Salisbury, Wilts, England.
Univ Cambridge, Dev Psychiat Sect, Cambridge CB2 1TN, England.
RP Bolton, PF (reprint author), Inst Psychiat PO46, Child Adolescent Psychiat Dept, De Crespigny Pk,Denmark Hill, London SE4 8AF, England.
EM p.bolton@iop.kcl.ac.uk
RI Bolton, Patrick/E-8501-2010
OI Bolton, Patrick/0000-0002-5270-6262
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NR 31
TC 76
Z9 78
PU BLACKWELL PUBLISHING
PI OXFORD
PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND
SN 0021-9630
J9 J CHILD PSYCHOL PSYC
JI J. Child Psychol. Psychiatry
PD OCT
PY 2005
VL 46
IS 10
BP 1089
EP 1096
DI 10.1111/j.1469-7610.2005.01520.x
PG 8
WC Psychology, Developmental; Psychiatry; Psychology
SC Psychology; Psychiatry
GA 966FQ
UT WOS:000232005900010
PM 16178933
ER
PT J
AU Wand, G
AF Wand, G
TI The anxious amygdala: CREB signaling and predisposition to anxiety and
alcoholism
SO JOURNAL OF CLINICAL INVESTIGATION
LA English
DT Editorial Material
ID ELEMENT-BINDING PROTEIN; SUBJECTIVE RESPONSES; P RATS; ETHANOL;
DEPENDENCE; NUCLEUS; ABUSE; PHOSPHORYLATION; CONSUMPTION; ANTAGONISM
AB The amygdala is believed to play a key role in assigning emotional significance to specific sensory input, and conditions such as anxiety, autism, stress, and phobias are thought to be linked to its abnormal function. Growing evidence has also implicated the amygdala in mediation of the stress-dampening properties of alcohol. In this issue of the JCI, Pandey and colleagues identify a central amygdaloid signaling pathway involved in anxiety-like and alcohol-drinking behaviors in rats (see the related article beginning on page 2762). They report that decreased phosphorylation of cAMP responsive element-binding protein (CREB) resulted in decreased neuropeptide Y (NPY) expression in the central amygdala of alcohol-preferring rats, causing high anxiety-like behavior. Alcohol intake by these animals was shown to increase PKA-dependent CREB phosphorylation and thereby NPY expression, subsequently ameliorating anxiety-like behavior. These provocative data suggest that a CREB-dependent neuromechanism underlies high anxiety-like and excessive alcohol-drinking behavior.
C1 Johns Hopkins Med Inst, Sch Med, Dept Med & Psychiat, Baltimore, MD 21205 USA.
RP Wand, G (reprint author), Johns Hopkins Med Inst, Sch Med, Dept Med & Psychiat, Ross Res Bldg,Room 863,720 Rutland Ave, Baltimore, MD 21205 USA.
EM gwand@jhmi.edu
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NR 30
TC 22
Z9 24
PU AMER SOC CLINICAL INVESTIGATION INC
PI ANN ARBOR
PA 35 RESEARCH DR, STE 300, ANN ARBOR, MI 48103 USA
SN 0021-9738
J9 J CLIN INVEST
JI J. Clin. Invest.
PD OCT
PY 2005
VL 115
IS 10
BP 2697
EP 2699
DI 10.1172/JC126436
PG 3
WC Medicine, Research & Experimental
SC Research & Experimental Medicine
GA 971IE
UT WOS:000232376600020
PM 16200206
ER
PT J
AU Danfors, T
von Knorring, AL
Hartvig, P
Langstrom, B
Moulder, R
Stromberg, B
Torstenson, R
Wester, U
Watanabe, Y
Eeg-Olofsson, O
AF Danfors, T
von Knorring, AL
Hartvig, P
Langstrom, B
Moulder, R
Stromberg, B
Torstenson, R
Wester, U
Watanabe, Y
Eeg-Olofsson, O
TI Tetrahydrobiopterin in the treatment of children with autistic disorder
- A double-blind placebo-controlled crossover study
SO JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY
LA English
DT Article
ID CEREBROSPINAL-FLUID; INFANTILE-AUTISM
AB Twelve children, all boys, aged 4 to 7 years, with a diagnosis of autistic disorder and low concentrations of spinal 6R-l-erythro-5,6,7,8-tetrahydrobiopterin (tetrahydrobiopterin) were selected to participate in a double-blind, randomized, placebo-controlled, crossover study. The children received a daily dose of 3 mg tetrahydrobiopterin per kilogram during 6 months alternating with placebo. Treatment-induced effects were assessed with the Childhood Autism Rating Scale every third month. The results showed small nonsignificant changes in the total scores of Childhood Autism Rating Scale after 3- and 6-month treatment. Post hoe analysis looking at the 3 core symptoms of autism, that is, social interaction, communication, and stereotyped behaviors, revealed a significant improvement of the social interaction score after 6 months of active treatment. In addition, a high positive correlation was found between response of the social interaction score and IQ. The results indicate a possible effect of tetrahydrobiopterin treatment.
C1 Univ Uppsala, Dept Neurosci, S-75185 Uppsala, Sweden.
Univ Uppsala, Hosp Pharm, S-75185 Uppsala, Sweden.
PET Ctr, Uppsala, Sweden.
Uppsala Imanet AB, Uppsala, Sweden.
Dept Womens & Childrens Hlth, Uppsala, Sweden.
Osaka City Univ, Grad Sch Med, Dept Physiol, Osaka 558, Japan.
RP Danfors, T (reprint author), Univ Uppsala, Dept Neurosci, S-75185 Uppsala, Sweden.
EM torsten.danfors@neurologi.uu.se
CR Alin-Akerman B., 1980, GRIFFITHS DEV SCALES
Aman MG, 2004, CNS SPECTRUMS, V9, P36
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NR 16
TC 16
Z9 18
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3261 USA
SN 0271-0749
J9 J CLIN PSYCHOPHARM
JI J. Clin. Psychopharmacol.
PD OCT
PY 2005
VL 25
IS 5
BP 485
EP 489
DI 10.1097/01.jcp.0000177667.35016.e9
PG 5
WC Pharmacology & Pharmacy; Psychiatry
SC Pharmacology & Pharmacy; Psychiatry
GA 970EH
UT WOS:000232287500017
PM 16160627
ER
PT J
AU Kyrkou, M
AF Kyrkou, M
TI Health issues and quality of life in women with intellectual disability
SO JOURNAL OF INTELLECTUAL DISABILITY RESEARCH
LA English
DT Article
DE dysmenorrhoea; intellectual disability; period pain; premenstrual
syndrome; premenstrual tension
AB Background Although there is anecdotal evidence of an increase in both period pain and premenstrual syndrome (PMS) in women with intellectual disabilities (ID), there are only brief mentions of it in the literature.
Method Questionnaires were distributed to parents of women with Down syndrome (DS) or Autism Spectrum Disorder (ASD), resulting in 24 respondents from Australia and New Zealand. The purpose of the study was to ascertain how period pain and PMS presents in women with ID.
Results Results were analyzed by disability group, and communication ability. Women with DS were more often able to state that they had pain, or point to the location of the pain than women with either autism or Asperger Syndrome (AS). Additionally, women with DS or ASD appeared to have a higher rate of period pain than women in the general population, but the presence of pain more often had to be deduced from behavioural changes.
Conclusion Further research with a larger number of women with disability, and across a wider range of disabilities is required to determine generalizability of these findings.
C1 Flinders Univ S Australia, Adelaide, SA 5001, Australia.
RP Kyrkou, M (reprint author), Flinders Univ S Australia, GPO Box 2100, Adelaide, SA 5001, Australia.
EM margaret.kyrkou@flinders.edu.au
CR Attwood T., 1998, ASPERGERS SYNDROME G
BUDEIRI DJ, 1994, BRIT J OBSTET GYNAEC, V101, P689, DOI 10.1111/j.1471-0528.1994.tb13186.x
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MOOS RH, 1968, PSYCHOSOM MED, V30, P853
RICHARDSON JTE, 1992, COGNITION MENSTRUAL, P1
TAYLOR G, 1995, AUTISM PROFESSIONAL, P47
NR 9
TC 15
Z9 15
PU BLACKWELL PUBLISHING
PI OXFORD
PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND
SN 0964-2633
J9 J INTELL DISABIL RES
JI J. Intell. Disabil. Res.
PD OCT
PY 2005
VL 49
BP 770
EP 772
DI 10.1111/j.1365-2788.2005.00749.x
PN 10
PG 3
WC Education, Special; Genetics & Heredity; Clinical Neurology; Psychiatry;
Rehabilitation
SC Education & Educational Research; Genetics & Heredity; Neurosciences &
Neurology; Psychiatry; Rehabilitation
GA 964FG
UT WOS:000231863600013
PM 16162125
ER
PT J
AU Parracho, HMRT
Bingham, MO
Gibson, GR
McCartney, AL
AF Parracho, HMRT
Bingham, MO
Gibson, GR
McCartney, AL
TI Differences between the gut microflora of children with autistic
spectrum disorders and that of healthy children
SO JOURNAL OF MEDICAL MICROBIOLOGY
LA English
DT Article
ID IN-SITU HYBRIDIZATION; OLIGONUCLEOTIDE PROBES; ONSET AUTISM; CLOSTRIDIA;
FECES
AB Children with autistic spectrum disorders (ASDs) tend to suffer from severe gastrointestinal problems. Such symptoms may be due to a disruption of the indigenous gut flora promoting the overgrowth of potentially pathogenic micro-organisms. The faecal flora of patients with ASDs was studied and compared with those of two control groups (healthy siblings and unrelated healthy children). Faecal bacterial populations were assessed through the use of a culture-independent technique, fluorescence in situ hybridization, using oligonucleotide probes targeting predominant components of the gut flora. The faecal flora of ASD patients contained a higher incidence of the Clostridium histolyticum group (Clostridium clusters I and 11) of bacteria than that of healthy children. However, the non-autistic sibling group had an intermediate level of the C. histolyticum group, which was not significantly different from either of the other subject groups. Members of the C. histolyticum group are recognized toxin-producers and may contribute towards gut dysfunction, with their metabolic products also exerting systemic effects. Strategies to reduce clostridial population levels harboured by ASD patients or to improve their gut microflora profile through dietary modulation may help to alleviate gut disorders common in such patients.
C1 Univ Reading, Food Microbial Sci Unit, Sch Food Biosci, Reading RG6 6AP, Berks, England.
RP McCartney, AL (reprint author), Univ Reading, Food Microbial Sci Unit, Sch Food Biosci, POB 226, Reading RG6 6AP, Berks, England.
EM a.l.mccartney@reading.ac.uk
RI Gibson, Glenn/A-9595-2009
CR AMANN RI, 1995, MICROBIOL REV, V59, P143
Baird G, 2003, BRIT MED J, V327, P488, DOI 10.1136/bmj.327.7413.488
Bolte ER, 1998, MED HYPOTHESES, V51, P133, DOI 10.1016/S0306-9877(98)90107-4
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NR 17
TC 128
Z9 139
PU SOC GENERAL MICROBIOLOGY
PI READING
PA MARLBOROUGH HOUSE, BASINGSTOKE RD, SPENCERS WOODS, READING RG7 1AG,
BERKS, ENGLAND
SN 0022-2615
J9 J MED MICROBIOL
JI J. Med. Microbiol.
PD OCT
PY 2005
VL 54
IS 10
BP 987
EP 991
DI 10.1099/jmm.0.46101-0
PG 5
WC Microbiology
SC Microbiology
GA 971JG
UT WOS:000232379500014
PM 16157555
ER
PT J
AU [Anonymous]
AF [Anonymous]
TI Gastroesophageal reflux in children with autism: How do children present
and can one test these children?
SO JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
LA English
DT Meeting Abstract
NR 0
TC 0
Z9 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3261 USA
SN 0277-2116
J9 J PEDIATR GASTR NUTR
JI J. Pediatr. Gastroenterol. Nutr.
PD OCT
PY 2005
VL 41
IS 4
BP 505
EP 505
PG 1
WC Gastroenterology & Hepatology; Nutrition & Dietetics; Pediatrics
SC Gastroenterology & Hepatology; Nutrition & Dietetics; Pediatrics
GA 970MW
UT WOS:000232315300065
ER
PT J
AU [Anonymous]
AF [Anonymous]
TI Gastrointestinal symptoms and intestinal disaccharidase activities in
children with autism
SO JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
LA English
DT Meeting Abstract
NR 0
TC 0
Z9 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3261 USA
SN 0277-2116
J9 J PEDIATR GASTR NUTR
JI J. Pediatr. Gastroenterol. Nutr.
PD OCT
PY 2005
VL 41
IS 4
BP 508
EP 508
PG 1
WC Gastroenterology & Hepatology; Nutrition & Dietetics; Pediatrics
SC Gastroenterology & Hepatology; Nutrition & Dietetics; Pediatrics
GA 970MW
UT WOS:000232315300074
ER
PT J
AU McDuffie, A
Yoder, P
Stone, W
AF McDuffie, A
Yoder, P
Stone, W
TI Prelinguistic predictors of vocabulary in young children with autism
spectrum disorders
SO JOURNAL OF SPEECH LANGUAGE AND HEARING RESEARCH
LA English
DT Review
DE autism spectrum disorders; language comprehension; language expression;
preschool children; language disorders
ID EARLY LANGUAGE-ACQUISITION; JOINT ATTENTION; NONVERBAL-COMMUNICATION;
DOWN-SYNDROME; INTENTIONAL COMMUNICATION; FOLLOW-UP;
INDIVIDUAL-DIFFERENCES; LATE TALKERS; SKILLS; INFANCY
AB Purpose: The goal of the current study was to identify a predictive model of vocabulary comprehension and production in a group of young children with autism spectrum disorders. Four prelinguistic behaviors were selected for consideration as predictors based on theoretical and empirical support for the relationship of these behaviors to language development.
Method: The study used a longitudinal correlational design. Participants were twenty-nine 2- and 3-year-olds diagnosed with autism spectrum disorders. The prelinguistic behaviors - attention-following, motor imitation, commenting, and requesting-were measured at the initial visit. Vocabulary comprehension and production were measured 6 months later.
Results: Commenting was the only unique predictor of comprehension after the degree of cognitive delay was controlled. Both commenting and motor imitation of actions without objects were unique predictors of production over and above the other skills and when the degree of cognitive delay was controlled.
Conclusions: The finding that both commenting and motor imitation simultaneously accounted for unique variance in vocabulary production is new to the literature and requires replication. However, results suggest that increasing behaviors that allow children with autism to make their current focus of attention obvious to social partners may be an effective approach for supporting word learning in young children with autism.
C1 Univ Wisconsin, Waisman Ctr, Madison, WI 53705 USA.
Vanderbilt Univ, Nashville, TN USA.
Vanderbilt Childrens Hosp, Nashville, TN USA.
RP McDuffie, A (reprint author), Univ Wisconsin, Waisman Ctr, Room 533A,1500 Highland Ave, Madison, WI 53705 USA.
EM mcduffie@waisman.wisc.edu
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NR 112
TC 42
Z9 44
PU AMER SPEECH-LANGUAGE-HEARING ASSOC
PI ROCKVILLE
PA 10801 ROCKVILLE PIKE, ROCKVILLE, MD 20852-3279 USA
SN 1092-4388
EI 1558-9102
J9 J SPEECH LANG HEAR R
JI J. Speech Lang. Hear. Res.
PD OCT
PY 2005
VL 48
IS 5
BP 1080
EP 1097
DI 10.1044/1092-4388(2005/075)
PG 18
WC Audiology & Speech-Language Pathology; Linguistics; Rehabilitation
SC Audiology & Speech-Language Pathology; Linguistics; Rehabilitation
GA 007IU
UT WOS:000234963100009
PM 16411797
ER
PT J
AU Brady, NC
Steeples, T
Fleming, K
AF Brady, NC
Steeples, T
Fleming, K
TI Effects of prelinguistic communication levels on initiation and repair
of communication in children with disabilities
SO JOURNAL OF SPEECH LANGUAGE AND HEARING RESEARCH
LA English
DT Article
DE communication breakdown; communication repair; gestures; prelinguistic
communication; developmental delay
ID INTENTIONAL COMMUNICATION; DOWN-SYNDROME; DEVELOPMENTAL-DISABILITIES;
NONVERBAL-COMMUNICATION; JOINT ATTENTION; LANGUAGE; AUTISM;
INTERVENTION; SPEECH; GESTURE
AB Purpose: This study examined the effects of expressive and receptive language levels on initiated and repaired communication acts by prelinguistic children with developmental disabilities.
Method: In this descriptive study, participants were 45 children between the ages of 3 and 6 years who had severe delays in expressive communication. Some children communicated with 12 or fewer spoken words; others communicated exclusively with gestures and vocalizations. Participants also had delays in receptive language, and 41 of the 45 had below average IQ scores. The children participated in a scripted interaction with examiners that was designed to provide opportunities to initiate requests and comments, and to repair communication breakdowns. Videotapes of these interactions were later coded for analysis.
Results: Regression models indicated that differences in children's expressive communication levels and receptive language scores significantly predicted children's commenting communication acts during the scripted interaction, even after the authors accounted for child IQ. Expressive communication level was also a significant predictor of initiated requests when the authors controlled for IQ. Expressive communication level contributed to the variance in children's repairs following communication breakdowns; however, this contribution was not significant.
Conclusion: Differences in levels of prelinguistic communication development predict commenting abilities in children with developmental disabilities but do not appear to predict likelihood to repair communication breakdowns.
C1 Univ Kansas, Schiefelbusch Inst Lifespan Studies, Lawrence, KS 66045 USA.
RP Brady, NC (reprint author), Univ Kansas, Schiefelbusch Inst Lifespan Studies, 1000 Sunnyside Dr, Lawrence, KS 66045 USA.
EM nbrady@ku.edu
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NR 71
TC 8
Z9 9
PU AMER SPEECH-LANGUAGE-HEARING ASSOC
PI ROCKVILLE
PA 10801 ROCKVILLE PIKE, ROCKVILLE, MD 20852-3279 USA
SN 1092-4388
J9 J SPEECH LANG HEAR R
JI J. Speech Lang. Hear. Res.
PD OCT
PY 2005
VL 48
IS 5
BP 1098
EP 1113
DI 10.1044/1092-4388(2005/076)
PG 16
WC Audiology & Speech-Language Pathology; Linguistics; Rehabilitation
SC Audiology & Speech-Language Pathology; Linguistics; Rehabilitation
GA 007IU
UT WOS:000234963100010
PM 16411798
ER
PT J
AU Jordan, B
AF Jordan, B
TI Autism test on sale ?
SO M S-MEDECINE SCIENCES
LA French
DT Article
RP Jordan, B (reprint author), Marseille Nice Genopole,Case 901,Parc Sci Luminy, F-13288 Marseille, France.
EM brjordan@club-internet.fr
NR 0
TC 5
Z9 5
PU MASSON EDITEUR
PI MOULINEAUX CEDEX 9
PA 21 STREET CAMILLE DESMOULINS, ISSY, 92789 MOULINEAUX CEDEX 9, FRANCE
SN 0767-0974
J9 M S-MED SCI
JI M S-Med. Sci.
PD OCT
PY 2005
VL 21
IS 10
BP 886
EP 887
DI 10.1051/medsci/20052110886
PG 2
WC Medicine, Research & Experimental
SC Research & Experimental Medicine
GA 976EU
UT WOS:000232716400026
PM 16197910
ER
PT J
AU Spear, HJ
AF Spear, HJ
TI The importance of giving voice to parents' concerns about the MMR
vaccine
SO MEDICAL SCIENCE MONITOR
LA English
DT Letter
ID AUTISM
C1 Liberty Univ, Lynchburg, VA 24505 USA.
RP Spear, HJ (reprint author), Liberty Univ, 1971 Univ Blvd, Lynchburg, VA 24505 USA.
EM hspear@liberty.edu
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NR 13
TC 0
Z9 0
PU INT SCIENTIFIC LITERATURE, INC
PI ALBERTSON
PA 1125 WILLIS AVE, ALBERTSON, NY 11507 USA
SN 1234-1010
J9 MED SCI MONITOR
JI Med. Sci. Monitor
PD OCT
PY 2005
VL 11
IS 10
BP LE13
EP LE14
PG 2
WC Medicine, Research & Experimental
SC Research & Experimental Medicine
GA 974AN
UT WOS:000232563800023
PM 16192905
ER
PT J
AU Hodapp, RM
Glidden, LM
Kaiser, AP
AF Hodapp, RM
Glidden, LM
Kaiser, AP
TI Siblings of persons with disabilities: Toward a research agenda
SO MENTAL RETARDATION
LA English
DT Editorial Material
ID MENTAL-RETARDATION; AUTISM; FAMILIES; CHILDREN
C1 Vanderbilt Kennedy Ctr, Dept Special Educ, Nashville, TN 37203 USA.
Vanderbilt Kennedy Ctr, Family Res Program, Nashville, TN 37203 USA.
St Marys Coll Maryland, Dept Special Educ, St Marys City, MD 20686 USA.
RP Hodapp, RM (reprint author), Vanderbilt Kennedy Ctr, Dept Special Educ, Peabody Box 328,230 Appleton Pl, Nashville, TN 37203 USA.
EM robert.hodapp@vanderbilt.edu
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NR 25
TC 39
Z9 39
PU AMER ASSOC MENTAL RETARDATION
PI WASHINGTON
PA 444 N CAPITOL ST, NW, STE 846, WASHINGTON, DC 20001-1512 USA
SN 0047-6765
J9 MENT RETARD
JI Ment. Retard.
PD OCT
PY 2005
VL 43
IS 5
BP 334
EP 338
PG 5
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA 972TN
UT WOS:000232476200003
PM 16131230
ER
PT J
AU Stoneman, Z
AF Stoneman, Z
TI Siblings of children with disabilities: Research themes
SO MENTAL RETARDATION
LA English
DT Article
ID MENTALLY-RETARDED CHILDREN; DOWNS-SYNDROME; BEHAVIORAL-ADJUSTMENT;
PERCEIVED COMPETENCE; HOME OBSERVATIONS; YOUNGER SIBLINGS; OLDER
SIBLINGS; SELF-CONCEPT; AUTISM; RETARDATION
AB Until the early 1980s, most researchers paid little attention to sibling relationships. Studies of mothers dominated the research agenda, to the almost total exclusion of fathers, extended families, and siblings. Although in early classic studies of families of children with disabilities, investigators embraced a family systems approach that included siblings (i.e., Farber & Jenne, 1963), this emphasis did not take root until recently. There has been an impressive growth in the number of published studies focusing on siblings of children with disabilities. In this paper, my goal is to examine themes in this research and reflect on our state of knowledge.
C1 Univ Georgia, Coll Family & Consumer Sci, Inst Human Dev & Disabil, Athens, GA 30602 USA.
RP Stoneman, Z (reprint author), Univ Georgia, Coll Family & Consumer Sci, Inst Human Dev & Disabil, Athens, GA 30602 USA.
EM zo@uga.edu
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NR 70
TC 61
Z9 61
PU AMER ASSOC MENTAL RETARDATION
PI WASHINGTON
PA 444 N CAPITOL ST, NW, STE 846, WASHINGTON, DC 20001-1512 USA
SN 0047-6765
J9 MENT RETARD
JI Ment. Retard.
PD OCT
PY 2005
VL 43
IS 5
BP 339
EP 350
PG 12
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA 972TN
UT WOS:000232476200004
PM 16131231
ER
PT J
AU Seltzer, MM
Greenberg, JS
Orsmond, GI
Lounds, J
AF Seltzer, MM
Greenberg, JS
Orsmond, GI
Lounds, J
TI Life course studies of siblings of individuals with developmental
disabilities
SO MENTAL RETARDATION
LA English
DT Article
ID MENTAL-RETARDATION; AGING PARENTS; ADULTS; CHILDREN; SUPPORT;
INVOLVEMENT; ILLNESS; AUTISM
C1 Univ Wisconsin, Waisman Ctr, Madison, WI 53705 USA.
Univ Wisconsin, Sch Social Work, Madison, WI 53705 USA.
Boston Univ, Dept Occupat Therapy & Rehabil Sci, Boston, MA 02215 USA.
RP Seltzer, MM (reprint author), Univ Wisconsin, Waisman Ctr, 1500 Highland Ave, Madison, WI 53705 USA.
EM MSeltzer@Waisman.Wisc.Edu
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NR 24
TC 24
Z9 24
PU AMER ASSOC MENTAL RETARDATION
PI WASHINGTON
PA 444 N CAPITOL ST, NW, STE 846, WASHINGTON, DC 20001-1512 USA
SN 0047-6765
J9 MENT RETARD
JI Ment. Retard.
PD OCT
PY 2005
VL 43
IS 5
BP 354
EP 359
PG 6
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA 972TN
UT WOS:000232476200006
PM 16131233
ER
PT J
AU Philippi, A
Roschmann, E
Tores, F
Lindenbaum, P
Benajou, A
Germain-Leclerc, L
Marcaillou, C
Fontaine, K
Vanpeene, M
Roy, S
Maillard, S
Decaulne, V
Saraiva, JP
Brooks, P
Rousseau, F
Hager, J
AF Philippi, A
Roschmann, E
Tores, F
Lindenbaum, P
Benajou, A
Germain-Leclerc, L
Marcaillou, C
Fontaine, K
Vanpeene, M
Roy, S
Maillard, S
Decaulne, V
Saraiva, JP
Brooks, P
Rousseau, F
Hager, J
TI Haplotypes in the gene encoding protein kinase c-beta (PRKCB1) on
chromosome 16 are associated with autism
SO MOLECULAR PSYCHIATRY
LA English
DT Article
DE autism; linkage mapping; SNP; haplotype; association; PRKCB1
ID PERVASIVE DEVELOPMENTAL DISORDERS; SEROTONIN TRANSPORTER GENE;
GENOMEWIDE SCREEN; LINKAGE ANALYSIS; GENOMIC SCREEN; SUSCEPTIBILITY
GENES; SPECTRUM DISORDERS; TOURETTES-SYNDROME; INFANTILE-AUTISM; LOCUS
AB Autism is a developmental disorder characterized by impairments in social interaction and communication associated with repetitive patterns of interest or behavior. Autism is highly influenced by genetic factors. Genome-wide linkage and candidate gene association approaches have been used to try and identify autism genes. A few loci have repeatedly been reported linked to autism. Several groups reported evidence for linkage to a region on chromosome 16p. We have applied a direct physical identity-by-descent (IBD) mapping approach to perform a high-density (0.85 megabases) genome-wide linkage scan in 116 families from the AGRE collection. Our results confirm linkage to a region on chromosome 16p with autism. High-resolution single-nucleotide polymorphism ( SNP) genotyping and analysis of this region show that haplotypes in the protein kinase c-beta gene are strongly associated with autism. An independent replication of the association in a second set of 167 trio families with autism confirmed our initial findings. Overall, our data provide evidence that the PRKCB1 gene on chromosome 16p may be involved in the etiology of autism.
C1 IntegraGen SA, F-91058 Evry, France.
RP Hager, J (reprint author), IntegraGen SA, 4 Rue Pierre Fontaine, F-91058 Evry, France.
EM jorg.hager@integragen.com
RI Lindenbaum, Pierre/A-7154-2008
OI Lindenbaum, Pierre/0000-0003-0148-9787
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NR 73
TC 35
Z9 35
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1359-4184
J9 MOL PSYCHIATR
JI Mol. Psychiatr.
PD OCT
PY 2005
VL 10
IS 10
BP 950
EP 960
DI 10.1038/sj.mp.4001704
PG 11
WC Biochemistry & Molecular Biology; Neurosciences; Psychiatry
SC Biochemistry & Molecular Biology; Neurosciences & Neurology; Psychiatry
GA 968FC
UT WOS:000232146300010
PM 16027742
ER
PT J
AU Tischfield, MA
Bosley, TM
Salih, MAM
Alorainy, IA
Sener, EC
Nester, MJ
Oystreck, DT
Chan, WM
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AF Tischfield, MA
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LA English
DT Article
ID CRANIAL NERVES; MUTANT MICE; EXPRESSION; HINDBRAIN; DEFECTS; HOX-1.6;
AUTISM; HOXB1; GENES; CELLS
AB We identified homozygous truncating mutations in HOXA1 in three genetically isolated human populations. The resulting phenotype includes horizontal gaze abnormalities, deafness, facial weakness, hypoventilation, vascular malformations of the internal carotid arteries and cardiac outflow tract, mental retardation and autism spectrum disorder. This is the first report to our knowledge of viable homozygous truncating mutations in any human HOX gene and of a mendelian disorder resulting from mutations in a human HOX gene critical for development of the central nervous system.
C1 Childrens Hosp, Dept Med, Program Genom, Boston, MA 02115 USA.
Harvard Univ, Sch Med, Div Med Sci, Program Neurosci, Boston, MA USA.
King Khalid Eye Specialist Hosp, Neuroophthalmol Div, Riyadh 11462, Saudi Arabia.
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King Khalid Univ Hosp, Coll Med, Dept Pediat, Div Pediat Neurol, Riyadh 11472, Saudi Arabia.
King Saud Univ, Coll Med, Dept Radiol & Diagnost Imaging, Riyadh 11461, Saudi Arabia.
Hacettepe Univ Hosp, Dept Ophthalmol, Ankara, Turkey.
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RP Engle, EC (reprint author), Childrens Hosp, Dept Med, Program Genom, Boston, MA 02115 USA.
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J9 NAT GENET
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PD OCT
PY 2005
VL 37
IS 10
BP 1035
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UT WOS:000232185600011
PM 16155570
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LA English
DT Review
DE autism; developmental disorders; ethyl mercury; dental amalgam; mercury;
thimerosal; neurotoxicity; estrogen; testosterone; methylation;
glutathion
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European Off, Samueli Inst, Freiburg, Germany.
Univ Northampton, Sch Social Sci, Northampton, England.
Univ Kentucky, Dept Chem, Lexington, KY 40506 USA.
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EM joachim.mutter@uniklinik-freiburg.de
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NR 80
TC 124
Z9 130
PU MAGHIRA & MAAS PUBLICATIONS
PI STOCKHOLM
PA PO BOX 26132, S-100 41 STOCKHOLM, SWEDEN
SN 0172-780X
J9 NEUROENDOCRINOL LETT
JI Neuroendocrinol. Lett.
PD OCT
PY 2005
VL 26
IS 5
BP 439
EP 446
PG 8
WC Endocrinology & Metabolism; Neurosciences
SC Endocrinology & Metabolism; Neurosciences & Neurology
GA 002LG
UT WOS:000234612300001
PM 16264412
ER
PT J
AU Herbert, MR
AF Herbert, MR
TI Large brains in autism: The challenge of pervasive abnormality
SO NEUROSCIENTIST
LA English
DT Review
DE autism; macrocephaly; connectivity; neuroinflammation; complex
processing; brain
ID DEVELOPMENTAL LANGUAGE DISORDER; CENTRAL-NERVOUS-SYSTEM;
HIGH-FUNCTIONING AUTISM; MATTER VOLUME INCREASE; CEREBRAL WHITE-MATTER;
CORPUS-CALLOSUM SIZE; HEAD CIRCUMFERENCE; SPECTRUM DISORDER;
ASPERGER-SYNDROME; INFANTILE-AUTISM
AB The most replicated finding in autism neuroanatomy-a tendency to unusually large brains-has seemed paradoxical in relation to the specificity of the abnormalities in three behavioral domains that define autism. We now know a range of things about this phenomenon, including that brains in autism have a growth spurt shortly after birth and then slow in growth a few short years afterward, that only younger but not older brains are larger in autism than in controls, that white matter contributes disproportionately to this volume increase and in a nonuniform pattern suggesting postnatal pathology, that functional connectivity among regions of autistic brains is diminished, and that neuroinflammation (including microgliosis and astrogliosis) appears to be present in autistic brain tissue from childhood through adulthood. Alongside these pervasive brain tissue and functional abnormalities, there have arisen theories of pervasive or widespread neural information processing or signal coordination abnormalities (such as weak central coherence, impaired complex processing, and underconnectivity), which are argued to underlie the specific observable behavioral features of autism. This convergence of findings and models suggests that a systems- and chronic disease-based reformulation of function and pathophysiology in autism needs to be considered, and it opens the possibility for new treatment targets.
C1 Harvard Univ, Massachusetts Gen Hosp, Sch Med, Ctr Morphometr Anal, Charlestown, MA 02129 USA.
RP Herbert, MR (reprint author), Harvard Univ, Massachusetts Gen Hosp, Sch Med, Ctr Morphometr Anal, 149 13th St,Room 6012, Charlestown, MA 02129 USA.
EM mherbert1@partners.org
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NR 125
TC 92
Z9 94
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1073-8584
J9 NEUROSCIENTIST
JI Neuroscientist
PD OCT
PY 2005
VL 11
IS 5
BP 417
EP 440
DI 10.1177/0091270005278866
PG 24
WC Clinical Neurology; Neurosciences
SC Neurosciences & Neurology
GA 966VX
UT WOS:000232052000010
PM 16151044
ER
PT J
AU Baron, M
AF Baron, M
TI The autism industry
SO NEW SCIENTIST
LA English
DT Letter
NR 0
TC 0
Z9 0
PU REED BUSINESS INFORMATION LTD
PI SUTTON
PA QUADRANT HOUSE THE QUADRANT, SUTTON SM2 5AS, SURREY, ENGLAND
SN 0262-4079
J9 NEW SCI
JI New Sci.
PD OCT 1
PY 2005
VL 188
IS 2519
BP 19
EP 19
PG 1
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 970RH
UT WOS:000232326800029
ER
PT J
AU Costello, E
AF Costello, E
TI Complementary and alternative therapies: Considerations for families
after international adoption
SO PEDIATRIC CLINICS OF NORTH AMERICA
LA English
DT Article
ID AUTISTIC SPECTRUM DISORDERS; MEDICINE USE; CHILDREN; SECRETIN; PLACEBO
AB Parents of children with atypical development often seek help from their primary care pediatrician. The incidence of developmental and/or behavioral challenges and atypical development is increased in adopted children. As the number of children adopted internationally increases, requests for advice from a knowledgeable and trusted clinician about specific therapeutic options also increase. As a result, primary care pediatric providers should be informed about the risks and benefits of potential therapies for families. The more traditional therapies, based on the biopsychosocial model of health, are covered elsewhere in this issue. Here, the less traditional yet extremely popular complementary and alternative therapies that many families pursue with or without the knowledge of their child's primary care provider are addressed. Not every possible complementary or alternative intervention is discussed; rather, the focus is on the most commonly used approaches advocated for children with developmental challenges as well as on other techniques that have generated huge interest despite potential danger or expense.
The increased use of complementary and alternative medicine (CAM) among the US population is well documented [1]. Rates of using CAM in children range from 20% to 40%; in many cases, the pediatrician is unaware of the use of these therapies in his or her patients [2,3]. The severity of an illness and parental use of CAM are strong factors determining its use in children [4]. Families of children with neurodevelopmental disorders, such as attention deficit disorder (ADD) and attention deficit hyperactivity disorder (ADHD), report frequent use of complementary treatments [4].
Studies by Levy and colleagues [5,6] at The Children's Hospital of Philadelphia suggest that 30% of children in their autism program were using alternative treatments and 9% were using potentially harmful treatments. The statement of the American Academy of Pediatrics (AAP) on counseling families regarding the use of CAM cites data suggesting that up to 50% of children with autism are using some form of complementary medicine (National Council for Reliable Health Information; available at: www.neaf.org).
Children may present with a range of developmental concerns after international adoption, with diagnoses often including a range of autistic spectrum disorders (ASDs; eg, autism, pervasive developmental disorders, Asperger disorder.) Up to 16% of children adopted from extremely depriving environments, such as orphanages in Romania, presented with autistic or "quasiautistic" symptoms [7].
Likely targets for intervention with respect to international adoptees may include symptoms of disorders of attachment, sensory defensiveness, repetitive behaviors, impaired language development (as distinct from speech development), disorders of learning and attention, organizational difficulty, executive dysfunction, processing disorders, and social impairments. New parents of adopted children, especially those for whom this is a first child, may present with concerns in any of these areas. As a result, therapies used in this population that are considered complementary or alternative, although in common use for children with a range of developmental concerns, include sensory integration treatment (SIT), pragmatic language therapy, dietary manipulation, chelation for toxic metals, antifungal therapy for presumed overgrowth of yeast, auditory integration training (AIT), avoidance of childhood immunizations, administration of secretin, and attachment therapies.
C1 So Jamaica Plain Hlth Ctr, Jamaica Plain, MA 02130 USA.
RP Costello, E (reprint author), So Jamaica Plain Hlth Ctr, 640 Ctr St, Jamaica Plain, MA 02130 USA.
EM quirkykids@aol.com
CR *AM AC CHILD AD PS, 2005, PRACT PAR ASS TREATM
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NR 35
TC 3
Z9 3
PU W B SAUNDERS CO
PI PHILADELPHIA
PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA
19106-3399 USA
SN 0031-3955
J9 PEDIATR CLIN N AM
JI Pediatr. Clin. N. Am.
PD OCT
PY 2005
VL 52
IS 5
BP 1463
EP +
DI 10.1016/j.pcl.2005.06.006
PG 17
WC Pediatrics
SC Pediatrics
GA 972AD
UT WOS:000232425300013
PM 16154472
ER
PT J
AU Indredavik, MS
Skranes, JS
Vik, T
Heyerdahl, S
Romundstad, P
Myhr, GE
Brubakk, AM
AF Indredavik, MS
Skranes, JS
Vik, T
Heyerdahl, S
Romundstad, P
Myhr, GE
Brubakk, AM
TI Low-birth-weight adolescents: Psychiatric symptoms and cerebral MRI
abnormalities
SO PEDIATRIC NEUROLOGY
LA English
DT Article
ID ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; BRAIN VOLUME ABNORMALITIES;
SCHOOL-AGE-CHILDREN; WHITE-MATTER; BORN; PRETERM; INFANTS; AUTISM;
PERFORMANCE; ADULTHOOD
AB To explore associations between psychiatric symptoms and cerebral magnetic resonance imaging abnormalities in low-birth-weight adolescents, 55 very low-birth-weight (<= 1500 gm), 54 term small for gestational age (birth weight < 10th centile) and 66 term control adolescents (birth weight >= 10th centile) were assessed at 14-15 years of age. Outcome measures were Schedule for Affective Disorders and Schizophrenia for School-Age Children, Attention-Deficit/Hyperactivity Disorder Rating Scale IV, Autism Spectrum Screening Questionnaire, and qualitatively assessed cerebral magnetic resonance images. The very low-birth-weight group manifested increased prevalence of psychiatric symptoms and disorders compared with controls (P < 0.001), especially symptoms of attention-deficit/hyperactivity disorder, and high frequency of ventricular dilatation, white matter reduction, thinning of corpus callosum, and gliosis (P < 0.01 vs controls). The Attention-Deficit/Hyperactivity Disorder Rating Scale score was significantly associated with white matter reduction and thinning of corpus callosum in this group. The term small for gestational age group had increased prevalence of psychiatric symptoms compared with control subjects, but not more frequent abnormalities on cerebral magnetic resonance imaging. In conclusion, attention-deficit/hyperactivity disorder symptoms were significantly associated with white matter reduction and thinning of corpus callosum in very low-birth-weight adolescents. No associations were found for other psychiatric symptoms and brain abnormalities in any of the groups. (c) 2005 by Elsevier Inc. All rights reserved.
C1 Norwegian Univ Sci & Technol, Fac Med, Dept Neurosci, NO-7489 Trondheim, Norway.
Ctr Child & Adolescent Mental Hlth Eastern & So, Oslo, Norway.
St Olavs Univ Hosp, Dept Radiol, MR Ctr, Trondheim, Norway.
RP Indredavik, MS (reprint author), Norwegian Univ Sci & Technol, Fac Med, Dept Neurosci, NO-7489 Trondheim, Norway.
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NR 31
TC 32
Z9 32
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0887-8994
J9 PEDIATR NEUROL
JI Pediatr. Neurol.
PD OCT
PY 2005
VL 33
IS 4
BP 259
EP 266
DI 10.1016/j.pediatrneurol.2005.05.002
PG 8
WC Clinical Neurology; Pediatrics
SC Neurosciences & Neurology; Pediatrics
GA 977OA
UT WOS:000232811900006
PM 16194724
ER
PT J
AU Palmen, SJMC
Pol, HEH
Kemner, C
Schnack, HG
Sitskoorn, MM
Appels, MCM
Kahn, RS
Van Engeland, H
AF Palmen, SJMC
Pol, HEH
Kemner, C
Schnack, HG
Sitskoorn, MM
Appels, MCM
Kahn, RS
Van Engeland, H
TI Brain anatomy in non-affected parents of autistic probands: a MRI study
SO PSYCHOLOGICAL MEDICINE
LA English
DT Article; Proceedings Paper
CT 3rd International Meeting for Autism Research
CY MAY 07-08, 2004
CL Sacramento, CA
ID TWINS DISCORDANT; COGNITIVE PHENOTYPE; HEAD CIRCUMFERENCE; SPECTRUM
DISORDER; MATTER VOLUME; WHITE-MATTER; GRAY-MATTER; CHILDREN;
SCHIZOPHRENIA; FAMILIES
AB Background. Autism is a neurodevelopmental disorder with an estimated genetic origin of 90%. Previous studies have reported an increase in brain volume of approximately 5% in autistic subjects, especially in children. If this increase in brain volume is genetically determined, biological parents of autistic probands might be expected to show brain enlargement, or at least intracranial enlargement, as well. Identifying structural brain abnormalities under genetic control is of particular importance as these could represent endophenotypes of autism.
Method. Using quantitative anatomic brain magnetic resonance imaging, volumes of intracranial, total brain, frontal, parietal, temporal and occipital lobe, cerebral and cortical gray and white matter, cerebellum, lateral ventricle, and third ventricle were measured in biological, non-affected parents of autistic probands (19 couples) and in healthy, closely matched control subjects (20 couples).
Results. No significant differences were found between the parents of the autistic probands and healthy control couples in any of the brain volumes. Adding gender as a factor in a second analysis did not reveal a significant interaction effect of gender by group.
Conclusions. The present sample of biological, non-affected parents of autistic probands did not show brain enlargements. As the intracranium is not enlarged, it is unlikely that the brain volumes of the parents of autistic probands have originally been enlarged and have been normalized. Thus, increased brain volume in autism might be caused by the interaction of paternal and maternal genes, possibly with an additional effect of environmental factors, or increased brain volumes might reflect phenotypes of autism.
C1 Univ Utrecht, Med Ctr, Dept Child & Adolescent Psychiat, Rudolf Magnus Inst Neurosci, NL-3584 CX Utrecht, Netherlands.
Univ Utrecht, Med Ctr, Dept Psychiat, Rudolf Magnus Inst Neurosci, NL-3584 CX Utrecht, Netherlands.
RP Palmen, SJMC (reprint author), Univ Utrecht, Med Ctr, Dept Child & Adolescent Psychiat, Rudolf Magnus Inst Neurosci, HP A01-468,Heidelberglaan 100, NL-3584 CX Utrecht, Netherlands.
EM s.palmen@azu.nl
RI Hulshoff Pol, Hilleke/B-4795-2014
OI Hulshoff Pol, Hilleke/0000-0002-2038-5281
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NR 58
TC 8
Z9 9
PU CAMBRIDGE UNIV PRESS
PI NEW YORK
PA 40 WEST 20TH ST, NEW YORK, NY 10011-4211 USA
SN 0033-2917
J9 PSYCHOL MED
JI Psychol. Med.
PD OCT
PY 2005
VL 35
IS 10
BP 1411
EP 1420
DI 10.1017/S0033291705005015
PG 10
WC Psychology, Clinical; Psychiatry; Psychology
SC Psychology; Psychiatry
GA 974JZ
UT WOS:000232589000003
PM 16164765
ER
PT J
AU Clarke, A
AF Clarke, A
TI How to live with autism and Asperger syndrome: Practical strategies for
parents and professionals
SO PSYCHOLOGIST
LA English
DT Book Review
CR WILLIAMS C, 2004, LIVE AUTISM ASPERGER
NR 1
TC 0
Z9 0
PU BRITISH PSYCHOLOGICAL SOC
PI LEICESTER
PA ST ANDREWS HOUSE, 48 PRINCESS RD EAST, LEICESTER LE1 7DR, LEICS, ENGLAND
SN 0952-8229
J9 PSYCHOLOGIST
JI Psychologist
PD OCT
PY 2005
VL 18
IS 10
BP 629
EP 629
PG 1
WC Psychology, Multidisciplinary
SC Psychology
GA 976YU
UT WOS:000232770400043
ER
PT J
AU Craig, HK
Telfer, AS
AF Craig, HK
Telfer, AS
TI Hyperlexia and autism spectrum disorder - A case study of scaffolding
language growth over time
SO TOPICS IN LANGUAGE DISORDERS
LA English
DT Article
DE autism spectrum disorder; decoding; hyperlexia; language intervention;
priming; scaffolding
ID COMPREHENSION; CHILDREN; SKILLS
AB This case study describes Jason, a child with an autism spectrum disorder and hyperlexia. Hyperlexia is a condition characterized by precocious single-word recognition skills and weaker comprehension skills. Jason demonstrated advanced writing skills and a strong general preference for learning materials presented visually rather than orally. His speech-language pathologists, parents, tutors, and teachers used his exceptional skills in decoding and writing to scaffold his growth in oral language comprehension and interactive turn-taking over time. His reading skills supported his learning to comprehend Wh-questions presented orally, and to take turns appropriately in individual and group language intervention. In addition, visual scaffolding was used to prime the language necessary to complete lessons in the academic content areas, with positive outcomes. Overall, the case study underscores the need for clinicians to look at a child's behavioral profile in a comprehensive way so that no potential supports for language growth are overlooked.
C1 Univ Michigan, Univ Ctr Dev Language & Literacy, Ann Arbor, MI 48109 USA.
RP Craig, HK (reprint author), Univ Michigan, Univ Ctr Dev Language & Literacy, 1111 E Catherine St, Ann Arbor, MI 48109 USA.
EM hkc@umich.edu
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NR 33
TC 3
Z9 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3261 USA
SN 0271-8294
J9 TOP LANG DISORD
JI Top. Lang. Disord.
PD OCT-DEC
PY 2005
VL 25
IS 4
BP 364
EP 374
PG 11
WC Linguistics; Rehabilitation
SC Linguistics; Rehabilitation
GA 987AV
UT WOS:000233491700011
ER
PT J
AU Diehl, SF
Ford, CS
Federico, J
AF Diehl, SF
Ford, CS
Federico, J
TI The communication journey of a fully included child with an autism
spectrum disorder
SO TOPICS IN LANGUAGE DISORDERS
LA English
DT Article
DE autism; collaboration; inclusion; language; literacy; pragmatics
ID PERVASIVE DEVELOPMENTAL DISORDER; SCRIPT-FADING PROCEDURE;
TEACHING-CHILDREN; THOUGHT-BUBBLES; SKILLS; MODEL; STUDENTS; MIND
AB This article follows Jose, a child with autism spectrum disorder, through his communication journey from age 3 to age 11. His journey illustrates many of the characteristics and challenges of individuals with autism spectrum disorders, as they become a part of the literate community in the general education classroom. Collaborative, family-based teaming strategies that supported Jose's language and literacy learning from kindergarten through fourth grade are described. The article credits early, intensive intervention based on the family's concerns and goals for meaningful outcomes and communicative competence across learning contexts and communicative partners. Speech-language pathologists' roles as advocates for all students to have access to the social and literate community are also highlighted.
C1 Dept Commun Sci & Disorders, Tampa, FL 33620 USA.
RP Diehl, SF (reprint author), Dept Commun Sci & Disorders, 4202 E Fowler Ave,PCD 1017, Tampa, FL 33620 USA.
EM dieh1@cas.usf.edu
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NR 54
TC 2
Z9 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3261 USA
SN 0271-8294
J9 TOP LANG DISORD
JI Top. Lang. Disord.
PD OCT-DEC
PY 2005
VL 25
IS 4
BP 375
EP 387
PG 13
WC Linguistics; Rehabilitation
SC Linguistics; Rehabilitation
GA 987AV
UT WOS:000233491700012
ER
PT J
AU Hahn, A
Neubauer, BA
AF Hahn, A
Neubauer, BA
TI Autism and metabolic disorders - a rational approach
SO ZEITSCHRIFT FUR KINDER-UND JUGENDPSYCHIATRIE UND PSYCHOTHERAPIE
LA German
DT Review
DE autism; inborn errors of metabolism; diagnostics; therapy
ID LEMLI-OPITZ-SYNDROME; SEMIALDEHYDE DEHYDROGENASE-DEFICIENCY;
ADENYLOSUCCINATE LYASE DEFICIENCY; PERVASIVE DEVELOPMENTAL DISORDER;
PYRIDOXINE-DEPENDENT SEIZURES; INBORN ERROR; SPECTRUM DISORDERS;
INTRAVENOUS IMMUNOGLOBULIN; PYRIMIDINE DEGRADATION; CLINICAL PHENOTYPE
AB The causes of autism are heterogenous and predominantly genetically determined. An exact aetiology is founf in less than 10% of affected patients. The disappointment about low rates of success in identifying a definite pathology, numerous reports about the association of autism and <>, and rumours of <> after application of various drugs and dietary regimes have resulted in substantial confusion about meaningful diagnostic procedures and rational therapies for subjects with autism. The aim of this report is to give an overview about rare, genetically determined neurometabolic disorders (inborn errors of metabolism) that are evidently (e.g. Smith-Lemli-Opitz Syndrome) or allegedly (e.g. succinate semialdehyde dehydrogenase deficiency) associated with autism-specific symptoms. Affected patientsusually display additional neurological symptoms. Procedures required to establish the diagnosis and eventual therapeutic consequences derived from a specific metabolic defect are presented. In additon to these well-defined neurometabolic disorders for which there are rational therapeutic strategies, hypotheses about the association of autismwith <> that could not be confirmed or were clearly falsified are discussed.
C1 Univ Giessen, Zentrum Kinderheilkunde, Abt Neuropadiat & Sozialpadiat, DE-35385 Giessen, Germany.
RP Hahn, A (reprint author), Univ Giessen, Zentrum Kinderheilkunde, Abt Neuropadiat & Sozialpadiat, Feulgenstr 12, DE-35385 Giessen, Germany.
EM Andreas.Hahn@paediat.med.uni-giessen.de
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NR 79
TC 3
Z9 3
PU VERLAG HANS HUBER
PI BERN 9
PA LANGGASS-STRASSE 76, CH-3000 BERN 9, SWITZERLAND
SN 1422-4917
J9 Z KINDER JUG-PSYCH
JI Z. Kinder-und Jugendpsy. Psychother.
PD OCT
PY 2005
VL 33
IS 4
BP 259
EP 271
DI 10.1024/1422-4917.33.4.259
PG 13
WC Psychiatry
SC Psychiatry
GA 978PE
UT WOS:000232884700002
PM 16294704
ER
PT J
AU Flagg, EJ
Cardy, JEO
Roberts, W
Roberts, TPL
AF Flagg, EJ
Cardy, JEO
Roberts, W
Roberts, TPL
TI Language lateralization development in children with autism: Insights
from the late field magnetoencephalogram
SO NEUROSCIENCE LETTERS
LA English
DT Article
DE lateralization index; hemispheric dominance; language processing;
autism; maturation; children; auditory processing
ID WADA PROCEDURE; DOMINANCE; VOWELS; MEG; SPEECH; BRAIN; INDIVIDUALS;
PERCEPTION; DISORDERS; ASYMMETRY
AB Left hemisphere dominance represents the typical language lateralization profile for the majority of neurologically healthy, right-handed individuals. We investigated hemispheric dominance for language in language-impaired children with autism and typically developing controls to investigate the hypothesis that atypical functional specialization for language represents one component of developmental language impairment in autism. Late field magnetoencephalography (MEG) recordings were used to calculate a hemispheric Lateralization Index from the neuromagnetic activity evoked by passive auditory presentation of vowel stimuli. Results indicate that children with autism and typically developing children follow opposite maturational trajectories in language lateralization; while leftward lateralization (i.e. left hemisphere dominance) emerged from bilaterally symmetric neuronal activation as age increased in our sample of typically developing children, rightward lateralization emerged from bilaterally symmetric activity as age increased in our sample of children with autism. (C) 2005 Elsevier Ireland Ltd. All rights reserved.
C1 Univ Toronto, Dept Med Imaging, Toronto, ON M5M 1G1, Canada.
Hosp Sick Children, Child Dev Ctr, Toronto, ON M5G 1X8, Canada.
RP Flagg, EJ (reprint author), Univ Toronto, Dept Med Imaging, 150 Coll St,Room 116, Toronto, ON M5M 1G1, Canada.
EM elissa.flagg@utoronto.ca
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NR 39
TC 51
Z9 51
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
IRELAND
SN 0304-3940
J9 NEUROSCI LETT
JI Neurosci. Lett.
PD SEP 30
PY 2005
VL 386
IS 2
BP 82
EP 87
DI 10.1016/j.neulet.2005.05.037
PG 6
WC Neurosciences
SC Neurosciences & Neurology
GA 955HG
UT WOS:000231215900004
PM 16046066
ER
PT J
AU Feigin, RD
AF Feigin, RD
TI Prospects for the future of child health through research
SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
LA English
DT Article
ID MATERNAL-BEHAVIOR; GENE-THERAPY; AUTISM; DISEASE; OBESITY; ADOLESCENTS;
ETIOLOGY; ORIGINS
AB Improvements in child health through research will be made at an increasingly accelerated pace during the post-genomic era. Advances made possible through genomics, proteomics, and the application of nanosystem technology, coupled with a greater understanding of the influence of the environment on human genes, will enhance our ability to prevent, modify, or cure numerous childhood disorders. This article reviews some of the more pressing and important causes of morbidity and mortality in children, discusses the manner in which some of the newer technologies may be applied to investigations of these disorders, and offers predictions concerning the effect that new discoveries may have in ameliorating the morbid consequences of childhood diseases. The need to design and implement prospective long-term studies to determine the most effective ways to reduce the burden of preventable problems, which are rooted in societal issues (child abuse, alcoholism, drug abuse, and homicide) is highlighted. Physician-scientists also must address the ethical, political, and social questions already raised by recent advances in medicine.
C1 Baylor Coll Med, Dept Pediat, Houston, TX 77030 USA.
Texas Childrens Hosp, Houston, TX 77030 USA.
RP Feigin, RD (reprint author), Baylor Coll Med, Dept Pediat, 1 Baylor Plaza, Houston, TX 77030 USA.
EM rfeigin@bcm.tmc.edu
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NR 42
TC 8
Z9 8
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 515 N STATE ST, CHICAGO, IL 60610 USA
SN 0098-7484
J9 JAMA-J AM MED ASSOC
JI JAMA-J. Am. Med. Assoc.
PD SEP 21
PY 2005
VL 294
IS 11
BP 1373
EP 1379
DI 10.1001/jama.294.11.1373
PG 7
WC Medicine, General & Internal
SC General & Internal Medicine
GA 965YW
UT WOS:000231987800011
PM 16174696
ER
PT J
AU Morrice, P
AF Morrice, P
TI Autism as metaphor (July 31, pg 23, 2005)
SO NEW YORK TIMES BOOK REVIEW
LA English
DT Correction
CR Morrice P, 2005, NY TIMES BK REV, P23
NR 1
TC 0
Z9 0
PU NEW YORK TIMES
PI NEW YORK
PA 229 W 43RD ST, NEW YORK, NY 10036-3959 USA
SN 0028-7806
J9 NY TIMES BK REV
JI N. Y. Times Book Rev.
PD SEP 18
PY 2005
BP 30
EP 30
PG 1
WC Humanities, Multidisciplinary
SC Arts & Humanities - Other Topics
GA 962YN
UT WOS:000231769600041
ER
PT J
AU Belinchon-Carmona, M
Posada-De la Paz, M
Artigas-Pallares, J
Canal-Bedia, R
Diez-Cuervo, A
Ferrari-Arroyo, MJ
Fuentes-Biggi, J
Hernandez, JM
Hervas-Zuniga, A
Idiazabal-Aletxa, MA
Martos-Perez, J
Mulas, F
Munoz-Yunta, JA
Palacios, S
Tamarit, J
Valdizan, JR
AF Belinchon-Carmona, M
Posada-De la Paz, M
Artigas-Pallares, J
Canal-Bedia, R
Diez-Cuervo, A
Ferrari-Arroyo, MJ
Fuentes-Biggi, J
Hernandez, JM
Hervas-Zuniga, A
Idiazabal-Aletxa, MA
Martos-Perez, J
Mulas, F
Munoz-Yunta, JA
Palacios, S
Tamarit, J
Valdizan, JR
CA Grp Estudio Trastornos Espectro
TI Best practice guidelines for research in autistic spectrum disorders
SO REVISTA DE NEUROLOGIA
LA Spanish
DT Article
DE autistic disorder case control studies; control groups; informed
consent; practice guidelines; recommendations; registries; research
design; research ethics
ID METHODOLOGICAL ISSUES; INTERVENTION; CLASSIFICATION; CHILDREN
AB Introduction. Achieving a better knowledge of autism and other pervasive developmental disorders known as autistic spectrum disorders (ASD), poses a major scientific challenge. These disorders are some of the earliest and most severe psychopathological disorders in infancy; they include an heterogeneous group of conditions; its prevalence rate seems to be continually increasing and they generate a significant social impact. Aims and development. Nowadays, there is a current international agreement on the general requirements to be fulfilled by research projects and the priority areas to be considered when developing ASD high quality research. In Spain, although there are some established research groups with broad experience and expertise in these disorders, public funding opportunities and research development are still scarce. For this reason, the Study Group of the Instituto de Salud Carlos III has generated by consensus some Good Practice Guidelines for Research in ASD. Conclusions. After comparing priorities and recommendations from international reference documents with the results obtained after having carried out an exhaustive bibliographic revision of articles published in autism in the last 30 years by Spanish authors, methodological and ethical recommendations are established. Finally, structural deficiencies to be corrected and emerging research initiatives to be supported are identified.
C1 Inst Salud Carlos III, IIER, Tecn Super, E-28029 Madrid, Spain.
Univ Autonoma Madrid, Fac Psicol, Dept Psicol Bas, Ctr Psicol Aplicada, Madrid, Spain.
Inst Salud Carlos III, IIER, Unidad Sindrome Aceite Tox, Madrid, Spain.
Corp Sanitaria Parc Tauli, Hosp Sabadell, Unidad Neuropediat, Sabadell, Spain.
Univ Salamanca, Fac Educ, Dept Personal Evaluac & Tratamiento Psicol, E-37008 Salamanca, Spain.
Comite Profesional Autism Res Review Int, Ascesor Med Asociaciones PAUTA JARES & APNA FESPA, San Diego, Spain.
Policlin Gipuzkoa & GAUTENA, Serv Psiquiatria InfantoJuvenil, San Sebastian, Spain.
Consejeria Educ Comun Autonoma Madrid, Equipo Especif Alterac Graves Desarrollo, Madrid, Spain.
Clin Univ Dexeus, Ctr Salud Mental Infantojuvenil, Hosp Mutua Terrassa, Barcelona, Spain.
Inst Neurocognit Incia, Barcelona, Spain.
Clin Ntra, Barcelona, Spain.
APNA, Serv Diagnost, Madrid, Spain.
Ctr Leo Kanner, Madrid, Spain.
Hosp Infantil Fe, Serv Neuropediat, Valencia, Spain.
INVANEP, Valencia, Spain.
IMAS, Hosp del Mar, Serv Neuropediat, Unidad Neuropediat, Barcelona, Spain.
Asociac Autismo Burgos, Burgos, Spain.
Hosp Univ Miguel Servet, Serv Neurofisiol Clin, Zaragoza, Spain.
Hosp Univ Miguel Servet, Unidad Trastornos Desarrollo, Zaragoza, Spain.
RP Ferrari-Arroyo, MJ (reprint author), Inst Salud Carlos III, IIER, Tecn Super, Pabellon 11,Sinesio Delgado 6, E-28029 Madrid, Spain.
EM mferrari@isciii.es
RI Canal Bedia, Ricardo/D-3116-2011
OI Canal Bedia, Ricardo/0000-0003-0247-0295
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NR 25
TC 6
Z9 6
PU REVISTA DE NEUROLOGIA
PI BARCELONA
PA C/O CESAR VIGUERA, EDITOR, APDO 94121, 08080 BARCELONA, SPAIN
SN 0210-0010
J9 REV NEUROLOGIA
JI Rev. Neurologia
PD SEP 16
PY 2005
VL 41
IS 6
BP 371
EP 377
PG 7
WC Clinical Neurology
SC Neurosciences & Neurology
GA 971DE
UT WOS:000232360700009
PM 16163659
ER
PT J
AU Seeman, C
AF Seeman, C
TI The science and fiction of autism.
SO LIBRARY JOURNAL
LA English
DT Book Review
C1 Univ Toledo Libs, Toledo, OH 43606 USA.
RP Seeman, C (reprint author), Univ Toledo Libs, Toledo, OH 43606 USA.
CR Schreibman L., 2005, SCI FICTION AUTISM
NR 1
TC 0
Z9 0
PU BOWKER MAGAZINE GROUP CAHNERS MAGAZINE DIVISION
PI NEW YORK
PA 249 W 17TH ST, NEW YORK, NY 10011 USA
SN 0363-0277
J9 LIBR J
JI Libr. J.
PD SEP 15
PY 2005
VL 130
IS 15
BP 79
EP 79
PG 1
WC Information Science & Library Science
SC Information Science & Library Science
GA 967XF
UT WOS:000232123800180
ER
PT J
AU Kim, JJ
Doop, ML
Blake, R
Park, S
AF Kim, JJ
Doop, ML
Blake, R
Park, S
TI Impaired visual recognition of biological motion in schizophrenia
SO SCHIZOPHRENIA RESEARCH
LA English
DT Article
DE schizophrenia; motion perception; biological motion; visual perception;
social function; superior temporal cortex
ID FORM-FROM-MOTION; PERCEPTION; MIND; DEFICITS; AUTISM; CORTEX; BRAIN;
SYMPTOMATOLOGY; HALOPERIDOL; ASSOCIATION
AB Background: Motion perception deficits have been suggested to be an important feature of schizophrenia but the behavioral consequences of such deficits are unknown. Biological motion refers to the movements generated by living beings. The human visual system rapidly and effortlessly detects and extracts socially relevant information from biological motion. A deficit in biological motion perception may have significant consequences for detecting and interpreting social information.
Methods: Schizophrenia patients and matched healthy controls were tested on two visual tasks: recognition of human activity portrayed in point-light animations (biological motion task) and a perceptual control task involving detection of a grouped figure against the background noise (global-form task). Both tasks required detection of a global form against background noise but only the biological motion task required the extraction of motion-related information.
Results: Schizophrenia patients performed as well as the controls in the global-form task, but were significantly impaired on the biological motion task. In addition, deficits in biological motion perception correlated with impaired social functioning as measured by the Zigler social competence scale [Zigler, E., Levine, J. (198 1). Premorbid competence in schizophrenia: what is being measured? Journal of Consulting and Clinical Psychology, 49, 96-105.].
Conclusion: The deficit in biological motion processing, which may be related to the previously documented deficit in global motion processing, could contribute to abnormal social functioning in schizophrenia. (c) 2005 Elsevier B.V. All rights reserved.
C1 Vanderbilt Univ, Dept Psychol, Nashville, TN 37240 USA.
Vanderbilt Univ, Ctr Integrat & Cognit Neurosci, Nashville, TN 37240 USA.
RP Park, S (reprint author), Vanderbilt Univ, Dept Psychol, 111 21st Ave S, Nashville, TN 37240 USA.
EM sohee.park@vanderbilt.edu
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NR 43
TC 51
Z9 52
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0920-9964
J9 SCHIZOPHR RES
JI Schizophr. Res.
PD SEP 15
PY 2005
VL 77
IS 2-3
BP 299
EP 307
DI 10.1016/j.schres.2005.04.006
PG 9
WC Psychiatry
SC Psychiatry
GA 962RE
UT WOS:000231749100018
PM 15922565
ER
PT J
AU Vorstman, JA
Franke, L
Staal, WG
Hochstenbach, RF
Voskamp, JE
van Daalen, E
Wijmenga, C
van Engeland, H
AF Vorstman, JA
Franke, L
Staal, WG
Hochstenbach, RF
Voskamp, JE
van Daalen, E
Wijmenga, C
van Engeland, H
TI A novel approach to the analysis of autism associated Cytogenetic
Regions Of Interest using gene interaction networks
SO AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
LA English
DT Meeting Abstract
CT 13th World Congress on Psychiatric Genetics
CY SEP 04-08, 2005
CL Boston, MA
SP Int Soc Psychiat Gen
C1 Univ Med Ctr Utrecht, Dept Child & Adolescent Psychiat, NL-3508 GA Utrecht, Netherlands.
Univ Med Ctr Utrecht, Rudolf Magnus Inst Neurosci, NL-3508 GA Utrecht, Netherlands.
Univ Penn, Childrens Hosp Philadelphia, Abramson Res Ctr, Div Human Genet, Philadelphia, PA 19104 USA.
EM vorstman@email.chop.edu
NR 0
TC 0
Z9 0
PU WILEY-LISS
PI HOBOKEN
PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 1552-4841
J9 AM J MED GENET B
JI Am. J. Med. Genet. B
PD SEP 5
PY 2005
VL 138B
IS 1
BP 6
EP 7
PG 2
WC Genetics & Heredity; Psychiatry
SC Genetics & Heredity; Psychiatry
GA 971BY
UT WOS:000232357300015
ER
PT J
AU Glaser, B
Monks, S
Gerrish, A
Dwyers, S
Ivanov, D
Norton, N
Williams, NM
Murphy, KC
O'Donovan, MC
Owen, MJ
AF Glaser, B
Monks, S
Gerrish, A
Dwyers, S
Ivanov, D
Norton, N
Williams, NM
Murphy, KC
O'Donovan, MC
Owen, MJ
TI TBX1 - A VCFS candidate with relevance to autism spectrum disorder and
schizophrenia?
SO AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
LA English
DT Meeting Abstract
CT 13th World Congress on Psychiatric Genetics
CY SEP 04-08, 2005
CL Boston, MA
SP Int Soc Psychiat Gen
C1 Cardiff Univ, Dept Psychol Med, Cardiff, S Glam, Wales.
Royal Coll Surgeons Ireland, Educ & Res Ctr, Beaumont Hosp, Dept Psychiat, Dublin 2, Ireland.
EM glaserb@Cardiff.ac.uk
RI Murphy, Kieran/D-3577-2012
NR 0
TC 0
Z9 0
PU WILEY-LISS
PI HOBOKEN
PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 1552-4841
J9 AM J MED GENET B
JI Am. J. Med. Genet. B
PD SEP 5
PY 2005
VL 138B
IS 1
BP 7
EP 7
PG 1
WC Genetics & Heredity; Psychiatry
SC Genetics & Heredity; Psychiatry
GA 971BY
UT WOS:000232357300017
ER
PT J
AU Ebstein, RP
Rosenberg, C
Salomon, S
Levi, S
Shulman, C
Dina, C
Yirmiya, N
AF Ebstein, RP
Rosenberg, C
Salomon, S
Levi, S
Shulman, C
Dina, C
Yirmiya, N
TI Association between the dopamine D5 receptor (DRD5) marker and autism
SO AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
LA English
DT Meeting Abstract
CT 13th World Congress on Psychiatric Genetics
CY SEP 04-08, 2005
CL Boston, MA
SP Int Soc Psychiat Gen
C1 Hebrew Univ Jerusalem, Sch Social Work, Jerusalem, Israel.
Herzog Hosp, Jerusalem, Israel.
Hadassah Hebrew Univ, Sch Med, Dept Child Psychiat, Jerusalem, Israel.
Genet Malad Multifactorielles Inst Biol Lille, Lille, France.
EM ebstein@mscc.huji.ac.il
RI Dina, Christian/D-3535-2015
NR 0
TC 0
Z9 0
PU WILEY-LISS
PI HOBOKEN
PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 1552-4841
J9 AM J MED GENET B
JI Am. J. Med. Genet. B
PD SEP 5
PY 2005
VL 138B
IS 1
BP 29
EP 29
PG 1
WC Genetics & Heredity; Psychiatry
SC Genetics & Heredity; Psychiatry
GA 971BY
UT WOS:000232357300096
ER
PT J
AU Koochek, M
Harvard, C
Qiao, Y
Fawcett, C
Malenfant, P
Creighton, S
Hildebrand, J
Holden, JJ
Rajcan-Separovic, E
Lewis, M
AF Koochek, M
Harvard, C
Qiao, Y
Fawcett, C
Malenfant, P
Creighton, S
Hildebrand, J
Holden, JJ
Rajcan-Separovic, E
Lewis, M
TI The identification of novel microdeletions and microduplications causing
autism spectrum disorder (ASD) using 1 MB array-comparative genomic
hybridization (array-CGH)
SO AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
LA English
DT Meeting Abstract
CT 13th World Congress on Psychiatric Genetics
CY SEP 04-08, 2005
CL Boston, MA
SP Int Soc Psychiat Gen
C1 Univ British Columbia, Dept Med Genet, Vancouver, BC V5Z 1M9, Canada.
Univ British Columbia, Dept Pathol, Vancouver, BC V5Z 1M9, Canada.
Queens Univ, Dept Physiol, Kingston, ON K7L 3N6, Canada.
Queens Univ, Dept Psychiat, Kingston, ON K7L 3N6, Canada.
EM maryamk@interchange.ubc.ca
NR 0
TC 0
Z9 0
PU WILEY-LISS
PI HOBOKEN
PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 1552-4841
J9 AM J MED GENET B
JI Am. J. Med. Genet. B
PD SEP 5
PY 2005
VL 138B
IS 1
BP 29
EP 29
PG 1
WC Genetics & Heredity; Psychiatry
SC Genetics & Heredity; Psychiatry
GA 971BY
UT WOS:000232357300097
ER
PT J
AU Mulligan, A
Butler, L
Sorohan, J
Fitzgerald, M
Gill, M
AF Mulligan, A
Butler, L
Sorohan, J
Fitzgerald, M
Gill, M
TI Symptoms of autism in Attention Deficit Hyperactivity Disorder
SO AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
LA English
DT Meeting Abstract
CT 13th World Congress on Psychiatric Genetics
CY SEP 04-08, 2005
CL Boston, MA
SP Int Soc Psychiat Genet
C1 Trinity Coll Dublin, Dublin, Ireland.
EM mulliga@tcd.ie
NR 0
TC 0
Z9 0
PU WILEY-LISS
PI HOBOKEN
PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 1552-4841
J9 AM J MED GENET B
JI Am. J. Med. Genet. B
PD SEP 5
PY 2005
VL 138B
IS 1
BP 60
EP 60
PG 1
WC Genetics & Heredity; Psychiatry
SC Genetics & Heredity; Psychiatry
GA 971BY
UT WOS:000232357300211
ER
PT J
AU Bachani, AM
Holmes, SE
Ingersoll, RG
Sutcliffe, JS
Folstein, S
Margolis, RL
AF Bachani, AM
Holmes, SE
Ingersoll, RG
Sutcliffe, JS
Folstein, S
Margolis, RL
TI FOXP2 polymorphisms in individuals with autism and prominent
abnormalities of speech and language
SO AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
LA English
DT Meeting Abstract
CT 13th World Congress on Psychiatric Genetics
CY SEP 04-08, 2005
CL Boston, MA
SP Int Soc Psychiat Gen
C1 Johns Hopkins Univ, Sch Med, Dept Psychiat, Baltimore, MD 21218 USA.
Johns Hopkins Univ, Sch Med, Inst Med Genet, Baltimore, MD 21218 USA.
Vanderbilt Univ, Dept Mol Physiol & Biophys, Baltimore, MD USA.
EM abachani@jhmi.edu
NR 0
TC 0
Z9 0
PU WILEY-LISS
PI HOBOKEN
PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 1552-4841
J9 AM J MED GENET B
JI Am. J. Med. Genet. B
PD SEP 5
PY 2005
VL 138B
IS 1
BP 64
EP 64
PG 1
WC Genetics & Heredity; Psychiatry
SC Genetics & Heredity; Psychiatry
GA 971BY
UT WOS:000232357300227
ER
PT J
AU Buttenschon, HN
Als, TD
El Daoud, A
Wang, AG
Borglum, AD
Kruse, TA
Lauritsen, MB
Mors, O
AF Buttenschon, HN
Als, TD
El Daoud, A
Wang, AG
Borglum, AD
Kruse, TA
Lauritsen, MB
Mors, O
TI The glutamate decarboxylase gene 1 as a potential candidate gene for
autism
SO AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
LA English
DT Meeting Abstract
CT 13th World Congress on Psychiatric Genetics
CY SEP 04-08, 2005
CL Boston, MA
SP Int Soc Psychiat Gen
C1 Aarhus Univ Hosp, Ctr Basic Psychiat Res, Aarhus, Denmark.
Copenhagen Univ Hosp, Dept Psychiat, Copenhagen, Denmark.
Natl Hosp, Dept Psychiat, Faroe Isl, Denmark.
Univ Aarhus, Inst Human Genet, DK-8000 Aarhus, Denmark.
Odense Univ Hosp, Dept Clin Biochem & Genet, Odense, Denmark.
EM tda@psykiatri.aaa.dk
NR 0
TC 0
Z9 0
PU WILEY-LISS
PI HOBOKEN
PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 1552-4841
J9 AM J MED GENET B
JI Am. J. Med. Genet. B
PD SEP 5
PY 2005
VL 138B
IS 1
BP 64
EP 64
PG 1
WC Genetics & Heredity; Psychiatry
SC Genetics & Heredity; Psychiatry
GA 971BY
UT WOS:000232357300226
ER
PT J
AU Cai, G
Ramoz, N
Reichert, JG
Smith, CJ
Corwin, TE
AF Cai, G
Ramoz, N
Reichert, JG
Smith, CJ
Corwin, TE
TI Association of autism with serotonin-related genes
SO AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
LA English
DT Meeting Abstract
CT 13th World Congress on Psychiatric Genetics
CY SEP 04-08, 2005
CL Boston, MA
SP Int Soc Psychiat Gen
C1 CUNY Mt Sinai Sch Med, New York, NY 10029 USA.
EM guiqing.cai@mssm.edu
NR 0
TC 0
Z9 0
PU WILEY-LISS
PI HOBOKEN
PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 1552-4841
J9 AM J MED GENET B
JI Am. J. Med. Genet. B
PD SEP 5
PY 2005
VL 138B
IS 1
BP 65
EP 65
PG 1
WC Genetics & Heredity; Psychiatry
SC Genetics & Heredity; Psychiatry
GA 971BY
UT WOS:000232357300230
ER
PT J
AU Campbell, DB
Persico, AM
Levitt, P
AF Campbell, DB
Persico, AM
Levitt, P
TI Functional variants in the c-Met receptor associated with autism
SO AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
LA English
DT Meeting Abstract
CT 13th World Congress on Psychiatric Genetics
CY SEP 04-08, 2005
CL Boston, MA
SP Int Soc Psychiat Gen
C1 Vanderbilt Univ, Vanderbilt Kennedy Ctr Res Human Dev, Nashville, TN USA.
Univ Campus Biomed, Lab Mol Psychiat & Neurogenet, Rome, Italy.
IRCCS, Fdn S Lucia, Rome, Italy.
EM daniel.campbell@vanderbilt.edu
NR 0
TC 0
Z9 0
PU WILEY-LISS
PI HOBOKEN
PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 1552-4841
J9 AM J MED GENET B
JI Am. J. Med. Genet. B
PD SEP 5
PY 2005
VL 138B
IS 1
BP 65
EP 65
PG 1
WC Genetics & Heredity; Psychiatry
SC Genetics & Heredity; Psychiatry
GA 971BY
UT WOS:000232357300231
ER
PT J
AU Cochrane, LE
Conroy, J
Segurado, R
Meally, E
Gill, M
Gallagher, L
AF Cochrane, LE
Conroy, J
Segurado, R
Meally, E
Gill, M
Gallagher, L
TI An association study and mutation screen of NLGN3 and NLGN4X in an Irish
population suffering autism
SO AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
LA English
DT Meeting Abstract
CT 13th World Congress on Psychiatric Genetics
CY SEP 04-08, 2005
CL Boston, MA
SP Int Soc Psychiat Gen
C1 Univ Dublin Trinity Coll, Dept Genet, Dublin 2, Ireland.
St James Hosp, Trinity Ctr Hlth Sci, Dept Psychiat, Dublin 8, Ireland.
EM cochranl@tcd.ie
RI Segurado, Ricardo/K-6116-2014
OI Segurado, Ricardo/0000-0002-3547-6733
CR CHUBYKIN, 2005, J BIOL CHEM
Comoletti D, 2004, J NEUROSCI, V24, P4889, DOI 10.1523/JNEUROSCI.0468-04.2004
Jamain S, 2003, NAT GENET, V34, P27, DOI 10.1038/ng1136
Laumonnier F, 2004, AM J HUM GENET, V74, P552, DOI 10.1086/382137
NR 4
TC 0
Z9 0
PU WILEY-LISS
PI HOBOKEN
PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 1552-4841
J9 AM J MED GENET B
JI Am. J. Med. Genet. B
PD SEP 5
PY 2005
VL 138B
IS 1
BP 65
EP 65
PG 1
WC Genetics & Heredity; Psychiatry
SC Genetics & Heredity; Psychiatry
GA 971BY
UT WOS:000232357300232
ER
PT J
AU Cohen, IL
Tsiouris, JA
AF Cohen, IL
Tsiouris, JA
TI Maternal recurrent mood disorders and high-functioning autism
SO AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
LA English
DT Meeting Abstract
CT 13th World Congress on Psychiatric Genetics
CY SEP 04-08, 2005
CL Boston, MA
SP Int Soc Psychiat Gen
C1 NYS Inst Basic Res, New York, NY USA.
EM ilcphd@gmail.com
NR 0
TC 0
Z9 0
PU WILEY-LISS
PI HOBOKEN
PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 1552-4841
J9 AM J MED GENET B
JI Am. J. Med. Genet. B
PD SEP 5
PY 2005
VL 138B
IS 1
BP 65
EP 66
PG 2
WC Genetics & Heredity; Psychiatry
SC Genetics & Heredity; Psychiatry
GA 971BY
UT WOS:000232357300233
ER
PT J
AU Conroy, J
Cochrane, L
Segurado, R
Meally, E
Green, A
Ennis, S
Gill, M
Gallagher, L
AF Conroy, J
Cochrane, L
Segurado, R
Meally, E
Green, A
Ennis, S
Gill, M
Gallagher, L
TI Further evidence supporting the role of ITGA4 as a candidate gene for
autism
SO AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
LA English
DT Meeting Abstract
CT 13th World Congress on Psychiatric Genetics
CY SEP 04-08, 2005
CL Boston, MA
SP Int Soc Psychiat Gen
ID LINKAGE
C1 Univ Dublin Trinity Coll, Dept Genet, Dublin 2, Ireland.
St James Hosp, Trinity Hlth Ctr, Dept Psychiat, Dublin 8, Ireland.
Our Ladys Hosp Sick Children, Dublin 12, Ireland.
EM conroyju@tcd.ie
RI Segurado, Ricardo/K-6116-2014
OI Segurado, Ricardo/0000-0002-3547-6733
CR BUXBAUM JD, 2001, AM J HUM GENET, V69, P470
Palferman S, 2001, AM J HUM GENET, V69, P570
Shao YJ, 2002, AM J HUM GENET, V70, P1058, DOI 10.1086/339765
NR 3
TC 1
Z9 1
PU WILEY-LISS
PI HOBOKEN
PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 1552-4841
J9 AM J MED GENET B
JI Am. J. Med. Genet. B
PD SEP 5
PY 2005
VL 138B
IS 1
BP 66
EP 66
PG 1
WC Genetics & Heredity; Psychiatry
SC Genetics & Heredity; Psychiatry
GA 971BY
UT WOS:000232357300234
ER
PT J
AU Cuccaro, ML
Donnelly, SL
Cope, HA
Wolpert, CM
Abramson, RK
Wright, HH
Hall, A
Pericak-Vance, MA
AF Cuccaro, ML
Donnelly, SL
Cope, HA
Wolpert, CM
Abramson, RK
Wright, HH
Hall, A
Pericak-Vance, MA
TI Refining the repetitive behavior phenotype in autism
SO AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
LA English
DT Meeting Abstract
CT 13th World Congress on Psychiatric Genetics
CY SEP 04-08, 2005
CL Boston, MA
SP Int Soc Psychiat Gen
C1 Duke Univ, Med Ctr, Ctr Human Genet, Durham, NC USA.
Univ S Carolina, SOM, Columbia, SC 29208 USA.
EM mike.cuccaro@duke.edu
NR 0
TC 0
Z9 0
PU WILEY-LISS
PI HOBOKEN
PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 1552-4841
J9 AM J MED GENET B
JI Am. J. Med. Genet. B
PD SEP 5
PY 2005
VL 138B
IS 1
BP 66
EP 66
PG 1
WC Genetics & Heredity; Psychiatry
SC Genetics & Heredity; Psychiatry
GA 971BY
UT WOS:000232357300235
ER
PT J
AU Curran, SR
Powell, J
Neale, BM
Dworzynski, K
Li, T
Thomas, S
Brown, J
Veltman, M
Rioberts, S
Murphy, D
Sham, P
Bolton, P
AF Curran, SR
Powell, J
Neale, BM
Dworzynski, K
Li, T
Thomas, S
Brown, J
Veltman, M
Rioberts, S
Murphy, D
Sham, P
Bolton, P
TI An association analysis of GABRB3, a candidate gene of the GABAA
receptor complex on chromosome 15Q and autism spectrum disorder
SO AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
LA English
DT Meeting Abstract
CT 13th World Congress on Psychiatric Genetics
CY SEP 04-08, 2005
CL Boston, MA
SP Int Soc Psychiat Gen
C1 Inst Psychiat, MRC, Social Genet & Dev Psychiat Ctr, London SE5 8AF, England.
Inst Psychiat, Dept Psychol Med, London SE5 8AF, England.
Inst Psychiat, Dept Neurosci, London SE5 8AF, England.
Salisbury Dist Hosp, Wessex Reg Genet Lab, Salisbury, Wilts, England.
Southampton Gen Hosp, Paediat Med Unit, Southampton SO9 4XY, Hants, England.
Univ Cambridge, Sect Dev Psychiat, Cambridge CB2 1TN, England.
EM s.curran@iop.kcl.ac.uk
RI Powell, John/G-4412-2011; Bolton, Patrick/E-8501-2010
OI Powell, John/0000-0001-6124-439X; Bolton, Patrick/0000-0002-5270-6262
NR 0
TC 0
Z9 0
PU WILEY-LISS
PI HOBOKEN
PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 1552-4841
J9 AM J MED GENET B
JI Am. J. Med. Genet. B
PD SEP 5
PY 2005
VL 138B
IS 1
BP 66
EP 66
PG 1
WC Genetics & Heredity; Psychiatry
SC Genetics & Heredity; Psychiatry
GA 971BY
UT WOS:000232357300236
ER
PT J
AU Ebstein, RP
Rosenberg, C
Salomon, S
Levi, S
Shulman, C
Dina, C
Yirmiya, N
AF Ebstein, RP
Rosenberg, C
Salomon, S
Levi, S
Shulman, C
Dina, C
Yirmiya, N
TI Confirmation of association between arginine vasopressin 1a receptor
(AVPR1a) and autism in a family-based study
SO AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
LA English
DT Meeting Abstract
CT 13th World Congress on Psychiatric Genetics
CY SEP 04-08, 2005
CL Boston, MA
SP Int Soc Psychiat Gen
C1 Hebrew Univ Jerusalem, Dept Psychol, IL-91905 Jerusalem, Israel.
S Herzog Mem Hosp, Jerusalem, Israel.
Hadassah Hebrew Univ Med Sch, Dept Child Psychiat, Jerusalem, Israel.
Hebrew Univ Jerusalem, Sch Social Work, Jerusalem, Israel.
Genet Malad Multifactorielles Inst Biol Lille, Lille, France.
EM ebstein@msce.huji.ac.il
RI Dina, Christian/D-3535-2015
CR Bachner-Melman R, 2005, J INDIVID DIFFER, V26, P2, DOI DOI 10.1027/1614-0001.26.1.2
NR 1
TC 0
Z9 0
PU WILEY-LISS
PI HOBOKEN
PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 1552-4841
J9 AM J MED GENET B
JI Am. J. Med. Genet. B
PD SEP 5
PY 2005
VL 138B
IS 1
BP 67
EP 67
PG 1
WC Genetics & Heredity; Psychiatry
SC Genetics & Heredity; Psychiatry
GA 971BY
UT WOS:000232357300237
ER
PT J
AU Elke, R
Anne, P
Fred, T
Livia, G
Francis, R
Joerg, H
AF Elke, R
Anne, P
Fred, T
Livia, G
Francis, R
Joerg, H
TI Identification of autism susceptibility genes on chromosome 16p and 5q
SO AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
LA English
DT Meeting Abstract
CT 13th World Congress on Psychiatric Genetics
CY SEP 04-08, 2005
CL Boston, MA
SP Int Soc Psychiat Gen
C1 IntegraGen SA, F-91000 Evry, France.
EM elke.roschmann@integragen.com
NR 0
TC 0
Z9 0
PU WILEY-LISS
PI HOBOKEN
PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 1552-4841
J9 AM J MED GENET B
JI Am. J. Med. Genet. B
PD SEP 5
PY 2005
VL 138B
IS 1
BP 67
EP 67
PG 1
WC Genetics & Heredity; Psychiatry
SC Genetics & Heredity; Psychiatry
GA 971BY
UT WOS:000232357300238
ER
PT J
AU Haines, JL
Schnetz-Boutaud, N
Anderson, B
Summar, ML
Cuccaro, M
Gilbert, JR
Pericak-Vance, MA
AF Haines, JL
Schnetz-Boutaud, N
Anderson, B
Summar, ML
Cuccaro, M
Gilbert, JR
Pericak-Vance, MA
TI Examination of serotonin related genes in autism
SO AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
LA English
DT Meeting Abstract
CT 13th World Congress on Psychiatric Genetics
CY SEP 04-08, 2005
CL Boston, MA
SP Int Soc Psychiat Gen
C1 Vanderbilt Univ, Ctr Human Genet Res, Nashville, TN USA.
Duke Univ, Ctr Human Genet, Durham, NC USA.
EM jonathan@chgr.mc.vanderbilt.edu
NR 0
TC 0
Z9 0
PU WILEY-LISS
PI HOBOKEN
PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 1552-4841
J9 AM J MED GENET B
JI Am. J. Med. Genet. B
PD SEP 5
PY 2005
VL 138B
IS 1
BP 67
EP 67
PG 1
WC Genetics & Heredity; Psychiatry
SC Genetics & Heredity; Psychiatry
GA 971BY
UT WOS:000232357300239
ER
PT J
AU Klauck, SM
Felder, B
Schuster, C
Beyer, KS
Benner, A
Poustka, F
Poustka, A
AF Klauck, SM
Felder, B
Schuster, C
Beyer, KS
Benner, A
Poustka, F
Poustka, A
CA IMGSAC
TI Association studies and mutation screening in the German sample of
patients with autism spectrum disorders
SO AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
LA English
DT Meeting Abstract
CT 13th World Congress on Psychiatric Genetics
CY SEP 04-08, 2005
CL Boston, MA
SP Int Soc Psychiat Gen
C1 German Canc Res Ctr, D-6900 Heidelberg, Germany.
Univ Frankfurt, Dept Child & Adolescent Psychiat, D-6000 Frankfurt, Germany.
EM s.klauck@dkfz.de
RI Bolton, Patrick/E-8501-2010; Bailey, Anthony/J-2860-2014
OI Bolton, Patrick/0000-0002-5270-6262; Bailey, Anthony/0000-0003-4257-972X
NR 0
TC 0
Z9 0
PU WILEY-LISS
PI HOBOKEN
PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 1552-4841
J9 AM J MED GENET B
JI Am. J. Med. Genet. B
PD SEP 5
PY 2005
VL 138B
IS 1
BP 67
EP 68
PG 2
WC Genetics & Heredity; Psychiatry
SC Genetics & Heredity; Psychiatry
GA 971BY
UT WOS:000232357300240
ER
PT J
AU Londino, DL
Carr, B
Sirota, EL
Corley, KM
Johnson, ME
Rausch, JL
AF Londino, DL
Carr, B
Sirota, EL
Corley, KM
Johnson, ME
Rausch, JL
TI Autism, Aspergers, and schizophrenia: Common endophenotypic and genetic
characteristics of negative symptom spectrum disorders
SO AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
LA English
DT Meeting Abstract
CT 13th World Congress on Psychiatric Genetics
CY SEP 04-08, 2005
CL Boston, MA
SP Int Soc Psychiat Gen
C1 Med Coll Georgia, Augusta, GA 30912 USA.
Lutheran Med Ctr, Brooklyn, NY USA.
EM jeffreyr@mcg.edu
NR 0
TC 0
Z9 0
PU WILEY-LISS
PI HOBOKEN
PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 1552-4841
J9 AM J MED GENET B
JI Am. J. Med. Genet. B
PD SEP 5
PY 2005
VL 138B
IS 1
BP 68
EP 69
PG 2
WC Genetics & Heredity; Psychiatry
SC Genetics & Heredity; Psychiatry
GA 971BY
UT WOS:000232357300244
ER
PT J
AU McLellan, A
Wynne, F
Ball, M
Moore, T
AF McLellan, A
Wynne, F
Ball, M
Moore, T
TI The XQ/YQ pseudoautosomal region (PAR2) is a susceptibility locus for
autism
SO AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
LA English
DT Meeting Abstract
CT 13th World Congress on Psychiatric Genetics
CY SEP 04-08, 2005
CL Boston, MA
SP Int Soc Psychiat Gen
C1 Natl Univ Ireland Univ Coll Cork, Biosci Inst, Dept Biochem, Cork, Ireland.
EM t.moore@ucc.ie
CR Martin ER, 2000, AM J HUM GENET, V67, P146, DOI 10.1086/302957
NR 1
TC 0
Z9 0
PU WILEY-LISS
PI HOBOKEN
PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 1552-4841
J9 AM J MED GENET B
JI Am. J. Med. Genet. B
PD SEP 5
PY 2005
VL 138B
IS 1
BP 68
EP 68
PG 1
WC Genetics & Heredity; Psychiatry
SC Genetics & Heredity; Psychiatry
GA 971BY
UT WOS:000232357300241
ER
PT J
AU Poelmans, G
Wheelwright, S
Baron-Cohen, S
Kent, L
AF Poelmans, G
Wheelwright, S
Baron-Cohen, S
Kent, L
TI Association findings for four autism candidate genes belonging to the
"neurobeachin pathway" in the Asperger syndrome
SO AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
LA English
DT Meeting Abstract
CT 13th World Congress on Psychiatric Genetics
CY SEP 04-08, 2005
CL Boston, MA
SP Int Soc Psychiat Gen
C1 Cambridgeshire & Peterborough MH NHS Trust, Croft Childrens Unit, Cambridge, England.
Univ Cambridge, Dept Child & Adolescent Psychiat, Cambridge, England.
EM Geert.Poelmans@cambsmh.nhs.uk
NR 0
TC 0
Z9 0
PU WILEY-LISS
PI HOBOKEN
PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 1552-4841
J9 AM J MED GENET B
JI Am. J. Med. Genet. B
PD SEP 5
PY 2005
VL 138B
IS 1
BP 68
EP 68
PG 1
WC Genetics & Heredity; Psychiatry
SC Genetics & Heredity; Psychiatry
GA 971BY
UT WOS:000232357300242
ER
PT J
AU Ramoz, N
Reichert, JG
Smith, CJ
Corwin, TE
Silverman, JM
Buxbaum, JD
AF Ramoz, N
Reichert, JG
Smith, CJ
Corwin, TE
Silverman, JM
Buxbaum, JD
TI Evidence for autism loci, in addition to AGC1, in the chromosome
2q24-q33 region
SO AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
LA English
DT Meeting Abstract
CT 13th World Congress on Psychiatric Genetics
CY SEP 04-08, 2005
CL Boston, MA
SP Int Soc Psychiat Gen
C1 CUNY Mt Sinai Sch Med, New York, NY 10029 USA.
EM nicolas.ramoz@mssm.edu
NR 0
TC 0
Z9 0
PU WILEY-LISS
PI HOBOKEN
PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 1552-4841
J9 AM J MED GENET B
JI Am. J. Med. Genet. B
PD SEP 5
PY 2005
VL 138B
IS 1
BP 68
EP 68
PG 1
WC Genetics & Heredity; Psychiatry
SC Genetics & Heredity; Psychiatry
GA 971BY
UT WOS:000232357300243
ER
PT J
AU Romano, V
Cali, F
Mirisola, M
Gallo, A
Angileri, L
D'Anna, R
Gambino, G
Ayala, GF
Seidita, G
Ragalmuto, A
Elia, M
AF Romano, V
Cali, F
Mirisola, M
Gallo, A
Angileri, L
D'Anna, R
Gambino, G
Ayala, GF
Seidita, G
Ragalmuto, A
Elia, M
TI Absence of mutations R451C and D396ter (1186 insT) in the neuroligins
nos. 3 and 4, genes, respectively, in 140 Italian patients with autism
spectrum disorders
SO AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
LA English
DT Meeting Abstract
CT 13th World Congress on Psychiatric Genetics
CY SEP 04-08, 2005
CL Boston, MA
SP Int Soc Psychiat Gen
C1 Univ Palermo, Dipartimento Biopatol & Metodol Biomed, I-90133 Palermo, Italy.
Univ Palermo, Ctr Interdipartimentale Ric Clin & Sperimentale A, I-90133 Palermo, Italy.
Assoc Oasi Maria SS IRCCS, Troina, EN, Italy.
PO Aiuto Materno, Palermo, Italy.
EM vromano@unipa.it
CR Jamain S, 2003, NAT GENET, V34, P27, DOI 10.1038/ng1136
NR 1
TC 0
Z9 0
PU WILEY-LISS
PI HOBOKEN
PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 1552-4841
J9 AM J MED GENET B
JI Am. J. Med. Genet. B
PD SEP 5
PY 2005
VL 138B
IS 1
BP 69
EP 69
PG 1
WC Genetics & Heredity; Psychiatry
SC Genetics & Heredity; Psychiatry
GA 971BY
UT WOS:000232357300245
ER
PT J
AU Ronald, A
Happe, F
Price, TS
Baron-Cohen, S
Plomin, R
AF Ronald, A
Happe, F
Price, TS
Baron-Cohen, S
Plomin, R
TI Investigating overlap in the 'triad of f impairments' that define autism
spectrum conditions: Evidence for genetic heterogeneity at the extreme
SO AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
LA English
DT Meeting Abstract
CT 13th World Congress on Psychiatric Genetics
CY SEP 04-08, 2005
CL Boston, MA
SP Int Soc Psychiat Genet
C1 Kings Coll London, Inst Psychiat, SGDP Ctr, London, England.
Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford OX1 2JD, England.
Univ Cambridge, Autism Res Ctr, Cambridge CB2 1TN, England.
EM a.ronald@iop.kcl.ac.uk
RI Happe, Francesca/D-5544-2012
CR DEFRIES JC, 1988, ACTA GENET MED GEMEL, V37, P205
RONALD A, 2002, AUTISM, V6, P9
NR 2
TC 0
Z9 0
PU WILEY-LISS
PI HOBOKEN
PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 1552-4841
J9 AM J MED GENET B
JI Am. J. Med. Genet. B
PD SEP 5
PY 2005
VL 138B
IS 1
BP 69
EP 70
PG 2
WC Genetics & Heredity; Psychiatry
SC Genetics & Heredity; Psychiatry
GA 971BY
UT WOS:000232357300246
ER
PT J
AU Schuster, C
Felder, B
Klauck, SM
Gohlke, H
Illig, T
Becker, T
Benner, A
Poustka, F
Poustka, A
AF Schuster, C
Felder, B
Klauck, SM
Gohlke, H
Illig, T
Becker, T
Benner, A
Poustka, F
Poustka, A
TI Haplotype analysis and association studies in autism candidate genes.
SO AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
LA English
DT Meeting Abstract
CT 13th World Congress on Psychiatric Genetics
CY SEP 04-08, 2005
CL Boston, MA
SP Int Soc Psychiat Gen
C1 German Canc Res Ctr, D-69120 Heidelberg, Germany.
GSF Natl Res Ctr Environm & Hlth, Inst Epidemiol, D-85764 Neuherberg, Germany.
Univ Bonn, Inst Med Biometry Informat & Epidemiol, D-53105 Bonn, Germany.
Univ Frankfurt, Dept Child & Adolescent Psychiat, D-60590 Frankfurt, Germany.
EM Claudia.Schuster@dkfz.de
NR 0
TC 0
Z9 0
PU WILEY-LISS
PI HOBOKEN
PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 1552-4841
J9 AM J MED GENET B
JI Am. J. Med. Genet. B
PD SEP 5
PY 2005
VL 138B
IS 1
BP 70
EP 70
PG 1
WC Genetics & Heredity; Psychiatry
SC Genetics & Heredity; Psychiatry
GA 971BY
UT WOS:000232357300247
ER
PT J
AU Segurado, R
Conroy, J
Cochrane, L
Gill, M
Gallagher, L
AF Segurado, R
Conroy, J
Cochrane, L
Gill, M
Gallagher, L
TI Replication of genetic association between autism and the SLC25A12 gene
on chromosome 2q
SO AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
LA English
DT Meeting Abstract
CT 13th World Congress on Psychiatric Genetics
CY SEP 04-08, 2005
CL Boston, MA
SP Int Soc Psychiat Gen
C1 Univ Dublin Trinity Coll, Dept Genet, Dublin 2, Ireland.
St James Hosp, Trinity Ctr Hlth Sci, Dept Psychiat, Dublin 8, Ireland.
EM rsegurdo@tcd.ie
RI Segurado, Ricardo/K-6116-2014
OI Segurado, Ricardo/0000-0002-3547-6733
NR 0
TC 0
Z9 0
PU WILEY-LISS
PI HOBOKEN
PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 1552-4841
J9 AM J MED GENET B
JI Am. J. Med. Genet. B
PD SEP 5
PY 2005
VL 138B
IS 1
BP 70
EP 70
PG 1
WC Genetics & Heredity; Psychiatry
SC Genetics & Heredity; Psychiatry
GA 971BY
UT WOS:000232357300248
ER
PT J
AU Sommer, SS
Yan, J
Bockholt, A
Yang, C
Cook, EH
Skinner, C
Schroer, R
Schwartz, CE
Feng, J
AF Sommer, SS
Yan, J
Bockholt, A
Yang, C
Cook, EH
Skinner, C
Schroer, R
Schwartz, CE
Feng, J
TI Excess of structural variants in the neurexin 1 beta gene in patients
with autism
SO AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
LA English
DT Meeting Abstract
CT 13th World Congress on Psychiatric Genetics
CY SEP 04-08, 2005
CL Boston, MA
SP Int Soc Psychiat Gen
C1 City Hope Natl Med Ctr, Dept Mol Genet, Duarte, CA 91010 USA.
Univ Chicago, Dept Psychiat, Chicago, IL 60637 USA.
Greenwood Genet Ctr, JC Self Res Inst, Greenwood, SC 29646 USA.
EM sommeradmin@coh.org
CR YAN, 2005, MOL PSYCHIAT, V10, P329
NR 1
TC 0
Z9 0
PU WILEY-LISS
PI HOBOKEN
PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 1552-4841
J9 AM J MED GENET B
JI Am. J. Med. Genet. B
PD SEP 5
PY 2005
VL 138B
IS 1
BP 70
EP 70
PG 1
WC Genetics & Heredity; Psychiatry
SC Genetics & Heredity; Psychiatry
GA 971BY
UT WOS:000232357300249
ER
PT J
AU Stachowiak, B
Harvey, C
Menon, SD
Mensah, AK
Mnatzakanian, N
Alfred, SE
Guo, R
Scherer, SW
Kennedy, JL
Roberts, W
Minassian, BA
Srivistava, AK
Vincent, JB
AF Stachowiak, B
Harvey, C
Menon, SD
Mensah, AK
Mnatzakanian, N
Alfred, SE
Guo, R
Scherer, SW
Kennedy, JL
Roberts, W
Minassian, BA
Srivistava, AK
Vincent, JB
TI Mutation analysis of the Rett syndrome gene (MECP2) exon 1 in autism and
mental retardation, and genetic studies of the distal portion of
chromosome Xq
SO AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
LA English
DT Meeting Abstract
CT 13th World Congress on Psychiatric Genetics
CY SEP 04-08, 2005
CL Boston, MA
SP Int Soc Psychiat Gen
C1 Univ Toronto, Mol Neuropsychiat & Dev Lab, Toronto, ON, Canada.
Univ Toronto, CAMH, Neurogenet Sect, Toronto, ON, Canada.
Univ Toronto, Dept Psychiat, Toronto, ON, Canada.
Greenwood Genet Ctr, JC Self Res Inst Human Genet, Greenwood, SC 29646 USA.
Hosp Sick Children, Program Genet & Genom Biol, Toronto, ON M5G 1X8, Canada.
Hosp Sick Children, Autism Res Unit, Toronto, ON M5G 1X8, Canada.
EM beata_stachowiak@camh.net
NR 0
TC 0
Z9 0
PU WILEY-LISS
PI HOBOKEN
PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 1552-4841
J9 AM J MED GENET B
JI Am. J. Med. Genet. B
PD SEP 5
PY 2005
VL 138B
IS 1
BP 70
EP 71
PG 2
WC Genetics & Heredity; Psychiatry
SC Genetics & Heredity; Psychiatry
GA 971BY
UT WOS:000232357300250
ER
PT J
AU Sutcliffe, JS
Delahanty, RJ
Prasad, HC
Han, Q
Jiang, L
Folstein, SE
Blakely, RD
AF Sutcliffe, JS
Delahanty, RJ
Prasad, HC
Han, Q
Jiang, L
Folstein, SE
Blakely, RD
TI Allelic heterogeneity at the serotonin transporter gene confers risk for
autism and rigid-compulsive behaviors
SO AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
LA English
DT Meeting Abstract
CT 13th World Congress on Psychiatric Genetics
CY SEP 04-08, 2005
CL Boston, MA
SP Int Soc Psychiat Gen
C1 Vanderbilt Univ, Ctr Mol Neurosci, Nashville, TN USA.
Vanderbilt Univ, Vanderbilt Kennedy Ctr, Nashville, TN USA.
Vanderbilt Univ, Ctr Human Genet Res, Nashville, TN USA.
Vanderbilt Univ, Dept Mol Physiol & Biophys, Nashville, TN USA.
Vanderbilt Univ, Dept Pharmacol, Nashville, TN USA.
Johns Hopkins Univ, Dept Psychiat & Behav Sci, Baltimore, MD 21218 USA.
EM james.s.sutcliffe@vanderbilt.edu
NR 0
TC 0
Z9 0
PU WILEY-LISS
PI HOBOKEN
PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 1552-4841
J9 AM J MED GENET B
JI Am. J. Med. Genet. B
PD SEP 5
PY 2005
VL 138B
IS 1
BP 71
EP 71
PG 1
WC Genetics & Heredity; Psychiatry
SC Genetics & Heredity; Psychiatry
GA 971BY
UT WOS:000232357300251
ER
PT J
AU van Daalen, E
Vorstman, JA
Staal, WG
Jalali, G
Emanuel, BS
van Engeland, H
AF van Daalen, E
Vorstman, JA
Staal, WG
Jalali, G
Emanuel, BS
van Engeland, H
TI Breakpoint mapping of a complex rearrangement of chromosome 13 in a
child with autism
SO AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
LA English
DT Meeting Abstract
CT 13th World Congress on Psychiatric Genetics
CY SEP 04-08, 2005
CL Boston, MA
SP Int Soc Psychiat Gen
C1 Univ Med Ctr Utrecht, Dept Child & Adolescent Psychiat, NL-3508 GA Utrecht, Netherlands.
Univ Med Ctr Utrecht, Rudolf Magnus Inst Neurosci, NL-3508 GA Utrecht, Netherlands.
Univ Penn, Childrens Hosp Philadelphia, Abramson Res Ctr, Div Human Genet, Philadelphia, PA 19104 USA.
EM vorstman@email.chop.edu
NR 0
TC 1
Z9 1
PU WILEY-LISS
PI HOBOKEN
PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 1552-4841
J9 AM J MED GENET B
JI Am. J. Med. Genet. B
PD SEP 5
PY 2005
VL 138B
IS 1
BP 71
EP 71
PG 1
WC Genetics & Heredity; Psychiatry
SC Genetics & Heredity; Psychiatry
GA 971BY
UT WOS:000232357300253
ER
PT J
AU Vincent, JB
Choufani, S
Horike, S
Skaug, J
Fernandez, B
Scherer, SW
AF Vincent, JB
Choufani, S
Horike, S
Skaug, J
Fernandez, B
Scherer, SW
TI An inversion INV (4) (p12-p15.3) associated with autism implicates the
4p GABA receptor gene cluster
SO AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
LA English
DT Meeting Abstract
CT 13th World Congress on Psychiatric Genetics
CY SEP 04-08, 2005
CL Boston, MA
SP Int Soc Psychiat Gen
C1 Ctr Addict & Mental Hlth, Neurogenet Sect, Toronto, ON, Canada.
Hosp Sick Children, Program Genet & Genom Biol, Toronto, ON M5G 1X8, Canada.
Mem Univ Newfoundland, St John, NF, Canada.
EM john_vincent@camh.net
NR 0
TC 0
Z9 0
PU WILEY-LISS
PI HOBOKEN
PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 1552-4841
J9 AM J MED GENET B
JI Am. J. Med. Genet. B
PD SEP 5
PY 2005
VL 138B
IS 1
BP 71
EP 71
PG 1
WC Genetics & Heredity; Psychiatry
SC Genetics & Heredity; Psychiatry
GA 971BY
UT WOS:000232357300252
ER
PT J
AU Weiss, LA
Kosova, G
Cook, EH
Ober, C
AF Weiss, LA
Kosova, G
Cook, EH
Ober, C
TI Relationships between variation in ITGB3, serotonin level, expression
level, slc6a4 and autism susceptibility
SO AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
LA English
DT Meeting Abstract
CT 13th World Congress on Psychiatric Genetics
CY SEP 04-08, 2005
CL Boston, MA
SP Int Soc Psychiat Gen
C1 Univ Chicago, Dept Human Genet, Chicago, IL 60637 USA.
Univ Chicago, Comm Genet, Chicago, IL 60637 USA.
Univ Chicago, Dept Psychiat, Chicago, IL 60637 USA.
Univ Chicago, Dept Pediat, Chicago, IL 60637 USA.
EM laweiss@uchicago.edu
NR 0
TC 0
Z9 0
PU WILEY-LISS
PI HOBOKEN
PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 1552-4841
J9 AM J MED GENET B
JI Am. J. Med. Genet. B
PD SEP 5
PY 2005
VL 138B
IS 1
BP 71
EP 72
PG 2
WC Genetics & Heredity; Psychiatry
SC Genetics & Heredity; Psychiatry
GA 971BY
UT WOS:000232357300254
ER
PT J
AU Ylisaukko-oja, T
Varilo, T
Kilpinen, H
Alen, R
Vanhala, R
Kempas, E
Elmohandness, M
von Wendt, L
Jarvela, I
Peltonen, L
AF Ylisaukko-oja, T
Varilo, T
Kilpinen, H
Alen, R
Vanhala, R
Kempas, E
Elmohandness, M
von Wendt, L
Jarvela, I
Peltonen, L
TI Genome-wide scan for autism in an extended pedigree from a regional
subisolate in Finland
SO AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
LA English
DT Meeting Abstract
CT 13th World Congress on Psychiatric Genetics
CY SEP 04-08, 2005
CL Boston, MA
SP Int Soc Psychiat Gen
C1 Natl Publ Hlth Inst, Dept Mol Med, Helsinki, Finland.
Univ Helsinki, Dept Med Genet, Helsinki, Finland.
Cent Hosp Cent Finland, Dept Child Neurol, Jyvaskyla, Finland.
Hosp Children & Adolescents, Unit Child Neurol, Helsinki, Finland.
Univ Helsinki, Cent Hosp, Mol Genet Lab, Helsinki, Finland.
EM tero.ylisaukko-cja@ktl.fi
RI Jarvela, Irma/L-5836-2013
NR 0
TC 0
Z9 0
PU WILEY-LISS
PI HOBOKEN
PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 1552-4841
J9 AM J MED GENET B
JI Am. J. Med. Genet. B
PD SEP 5
PY 2005
VL 138B
IS 1
BP 72
EP 72
PG 1
WC Genetics & Heredity; Psychiatry
SC Genetics & Heredity; Psychiatry
GA 971BY
UT WOS:000232357300255
ER
PT J
AU Lindstrom, K
Fernell, E
Westgren, M
AF Lindstrom, K
Fernell, E
Westgren, M
TI Developmental data in preschool children born after prolonged pregnancy
SO ACTA PAEDIATRICA
LA English
DT Article
DE developmental outcome; gestational age; postdate pregnancy; ultrasound
dating
ID POSTTERM PREGNANCY; HEAD CIRCUMFERENCE; LABOR; COMPLICATIONS; DISORDERS;
GESTATION; INDUCTION; DELIVERY; OUTCOMES; AUTISM
AB Aim: To evaluate children born post-term ( gestational age 542 weeks) with respect to developmental data obtained at the ages of 4 and 5.5 y. Methods: The study population included all children (n = 354) born in 1991 at Huddinge University Hospital with a gestational age of >= 42 wk. The births were identified and perinatal data were collected through the Swedish National Birth Registry. Developmental assessments from the child health centres were analysed. Children born at term, but before a gestational age of 42 wk, served as controls. Logistic regression analysis was used to analyse the data. Results: Children born post-term had more developmental deviations than the controls ( estimated odds ratio 2.20; 95% CI: 1.29 - 3.85). Boys had more deviations than girls ( estimated odds ratio 1.92; 95% CI: 1.11 - 3.45).
Conclusion: Our results indicate that there might be an association between post-term birth and developmental deviations.
C1 Karolinska Univ Hosp Huddinge, Childrens Hosp, Dept Neuropaediat, Stockholm, Sweden.
Astrid Lindgren Childrens Hosp, Dept Neuropaediat, Stockholm, Sweden.
Karolinska Univ Hosp Huddinge, Dept Obstet & Gynaecol, Stockholm, Sweden.
RP Lindstrom, K (reprint author), Karolinska Univ Hosp Huddinge, Childrens Hosp, Dept Neuropaediat, Stockholm, Sweden.
EM katarina.lindstrom@klinvet.ki.se
CR Alexander JM, 2000, OBSTET GYNECOL, V96, P291, DOI 10.1016/S0029-7844(00)00862-0
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NR 22
TC 13
Z9 13
PU TAYLOR & FRANCIS AS
PI OSLO
PA PO BOX 12 POSTHUSET, NO-0051 OSLO, NORWAY
SN 0803-5253
J9 ACTA PAEDIATR
JI Acta Paediatr.
PD SEP
PY 2005
VL 94
IS 9
BP 1192
EP 1197
DI 10.1080/08035250510032673
PG 6
WC Pediatrics
SC Pediatrics
GA 978OF
UT WOS:000232882200005
PM 16278984
ER
PT J
AU Ma, DQ
Whitehead, PL
Menold, MM
Martin, ER
Ashley-Koch, AE
Mei, H
Ritchie, MD
DeLong, GR
Abramson, RK
Wright, HH
Cuccaro, ML
Hussman, JP
Gilbert, JR
Pericak-Vance, MA
AF Ma, DQ
Whitehead, PL
Menold, MM
Martin, ER
Ashley-Koch, AE
Mei, H
Ritchie, MD
DeLong, GR
Abramson, RK
Wright, HH
Cuccaro, ML
Hussman, JP
Gilbert, JR
Pericak-Vance, MA
TI Identification of significant association and gene-gene interaction of
GABA receptor subunit genes in autism
SO AMERICAN JOURNAL OF HUMAN GENETICS
LA English
DT Article
ID MULTIFACTOR-DIMENSIONALITY REDUCTION; FAMILY-BASED TESTS; GENOMEWIDE
SCREEN; LINKAGE-DISEQUILIBRIUM; SUSCEPTIBILITY LOCI; GENOMIC SCREEN;
DISORDER; CHROMOSOME-15; DUPLICATION; TWIN
AB Autism is a common neurodevelopmental disorder with a significant genetic component. Existing research suggests that multiple genes contribute to autism and that epigenetic effects or gene-gene interactions are likely contributors to autism risk. However, these effects have not yet been identified. Gamma-aminobutyric acid (GABA), the primary inhibitory neurotransmitter in the adult brain, has been implicated in autism etiology. Fourteen known autosomal GABA receptor subunit genes were studied to look for the genes associated with autism and their possible interactions. Single-nucleotide polymorphisms (SNPs) were screened in the following genes: GABRG1, GABRA2, GABRA4, and GABRB1 on chromosome 4p12; GABRB2, GABRA6, GABRA1, GABRG2, and GABRP on 5q34-q35.1; GABRR1 and GABRR2 on 6q15; and GABRA5, GABRB3, and GABRG3 on 15q12. Intronic and/or silent mutation SNPs within each gene were analyzed in 470 white families with autism. Initially, SNPs were used in a family-based study for allelic association analysis-with the pedigree disequilibrium test and the family-based association test-and for genotypic and haplotypic association analysis-with the genotype- pedigree disequilibrium test (geno-PDT), the association in the presence of linkage (APL) test, and the haplotype family-based association test. Next, with the use of five refined independent marker sets, extended multifactor-dimensionality reduction (EMDR) analysis was employed to identify the models with locus joint effects, and interaction was further verified by conditional logistic regression. Significant allelic association was found for markers RS1912960 (in GABRA4; P = .01) and HCV9866022 (in GABRR2; P =.04). The geno-PDT found significant genotypic association for HCV8262334 (in GABRA2), RS1912960 and RS2280073 (in GABRA4), and RS2617503 and RS12187676 (in GABRB2). Consistent with the allelic and genotypic association results, EMDR confirmed the main effect at RS1912960 (in GABRA4). EMDR also identified a significant two-locus gene-gene effect model involving RS1912960 in GABRA4 and RS2351299 in GABRB1. Further support for this two-locus model came from both the multilocus geno-PDT and the APL test, which indicated a common genotype and haplotype combination positively associated with disease. Finally, these results were also consistent with the results from the conditional logistic regression, which confirmed the interaction between GABRA4 and GABRB1 (odds ratio = 2.9 for interaction term; P = .002). Through the convergence of all analyses, we conclude that GABRA4 is involved in the etiology of autism and potentially increases autism risk through interaction with GABRB1. These results support the hypothesis that GABA receptor subunit genes are involved in autism, most likely via complex gene-gene interactions.
C1 Duke Univ, Med Ctr, Ctr Human Genet, Durham, NC 27710 USA.
Duke Univ, Med Ctr, Div Pediat Neurol, Durham, NC 27710 USA.
N Carolina State Univ, Raleigh, NC 27695 USA.
Vanderbilt Univ, Ctr Human Genet Res, Nashville, TN USA.
Univ S Carolina, Sch Med, Columbia, SC 29208 USA.
Hussman Fdn, Ellicott City, MD USA.
RP Pericak-Vance, MA (reprint author), Duke Univ, Med Ctr, Ctr Human Genet, Box 3445,595 LaSalle St, Durham, NC 27710 USA.
EM mpericak.vance@duke.edu
RI Ritchie, Marylyn/C-1114-2012
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NR 65
TC 153
Z9 160
PU UNIV CHICAGO PRESS
PI CHICAGO
PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA
SN 0002-9297
J9 AM J HUM GENET
JI Am. J. Hum. Genet.
PD SEP
PY 2005
VL 77
IS 3
BP 377
EP 388
DI 10.1086/433195
PG 12
WC Genetics & Heredity
SC Genetics & Heredity
GA 956QE
UT WOS:000231314100005
PM 16080114
ER
PT J
AU Williams, KR
Wishart, JG
Pitcairn, TK
Willis, DS
AF Williams, KR
Wishart, JG
Pitcairn, TK
Willis, DS
TI Emotion recognition by children with Down syndrome: Investigation of
specific impairments and error patterns
SO AMERICAN JOURNAL ON MENTAL RETARDATION
LA English
DT Article
ID FRAGILE-X-SYNDROME; FACIAL EXPRESSIONS; MENTAL-RETARDATION;
YOUNG-CHILDREN; WILLIAMS-SYNDROME; SOCIAL-BEHAVIOR; AMYGDALA;
PRESCHOOLERS; VOLUMES; AUTISM
AB The ability of children with Down syndrome to recognize expressions of emotion was compared to performance in typically developing and nonspecific intellectual disability groups matched on either MA or a performance-related measure. Our goal was to (a) resolve whether specific emotions present recognition difficulties; (b) investigate patterns of errors; and (c) explore the relationships among emotion-recognition ability and cognitive, linguistic, and adaptive behavior levels. Emotion-recognition ability in the Down syndrome group was significantly poorer than in the typically developing group overall, particularly for fearful expressions. Error patterns and relationships between task performance and assessment measures also differed across groups. Findings are consistent with a neurological explanation of specific deficits in sociocognitive functioning in children with Down syndrome.
C1 Univ Edinburgh, Moray House Sch Educ, Edinburgh EH8 8AQ, Midlothian, Scotland.
RP Williams, KR (reprint author), Univ Edinburgh, Moray House Sch Educ, Holyrood Rd, Edinburgh EH8 8AQ, Midlothian, Scotland.
EM Katie.Williams@ed.ac.uk
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NR 54
TC 46
Z9 46
PU AMER ASSOC MENTAL RETARDATION
PI WASHINGTON
PA 444 N CAPITOL ST, NW, STE 846, WASHINGTON, DC 20001-1512 USA
SN 0895-8017
J9 AM J MENT RETARD
JI Am. J. Ment. Retard.
PD SEP
PY 2005
VL 110
IS 5
BP 378
EP 392
DI 10.1352/0895-8017(2005)110[378:ERBCWD]2.0.CO;2
PG 15
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA 962XI
UT WOS:000231766200007
PM 16080776
ER
PT J
AU Meresse, IG
Zilbovicius, M
Boddaert, N
Robel, L
Philippe, A
Sfaello, I
Laurier, L
Brunelle, F
Samson, Y
Mouren, MC
Chabane, N
AF Meresse, IG
Zilbovicius, M
Boddaert, N
Robel, L
Philippe, A
Sfaello, I
Laurier, L
Brunelle, F
Samson, Y
Mouren, MC
Chabane, N
TI Autism severity and temporal lobe functional abnormalities
SO ANNALS OF NEUROLOGY
LA English
DT Article
ID CEREBRAL-BLOOD-FLOW; CHILDHOOD AUTISM; COMPLEX SOUNDS; PERCEPTION;
INDIVIDUALS; DISORDERS; CORTEX
AB Two independent studies (1,2) have described bilateral temporal hypoperfusion in autistic children. Temporal regions are implicated in social perception, language, and "theory-of-mind"' abilities that are impaired in autism. We investigated a putative relationship between cerebral blood flow (rCBF) measured at rest and clinical profile of 45 autistic children (Autism Diagnostic Interview-Revised [ADI-R] scores). A whole-brain covariance analysis was performed. Significant negative correlation was observed between rCBF and ADI-R score in the left superior temporal gyrus. The more severe the autistic syndrome, the more rCBF is low in this region, suggesting that left superior temporal hypoperfusion is related to autistic behavior severity.
C1 CEA, Serv Hosp Frederic Joliot, DSV,ERM 0205, DRM,INSERM, F-91406 Orsay, France.
Hop Necker Enfants Malad, Serv Radiol Pediat, Paris, France.
Hop Robert Debre, Serv Pedopsychiat, F-75019 Paris, France.
Hop Necker Enfants Malad, Serv Pedopsychiat, Paris, France.
Hop Necker Enfants Malad, Dept Med Genet, Paris, France.
Hop La Pitie Salpetriere, AP HP, Serv Urgences Cerebro Vasc, Paris, France.
RP Zilbovicius, M (reprint author), CEA, Serv Hosp Frederic Joliot, DSV,ERM 0205, DRM,INSERM, 4 Pl Gen Leclerc, F-91406 Orsay, France.
EM zilbo@shfj.cea.fr
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NR 20
TC 42
Z9 42
PU WILEY-LISS
PI HOBOKEN
PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 0364-5134
J9 ANN NEUROL
JI Ann. Neurol.
PD SEP
PY 2005
VL 58
IS 3
BP 466
EP 469
DI 10.1002/ana.20597
PG 4
WC Clinical Neurology; Neurosciences
SC Neurosciences & Neurology
GA 961RJ
UT WOS:000231679200018
ER
PT J
AU Steiner, CE
Guerreiro, MM
Marques-De-Faria, AP
Lopes-Cendes, I
AF Steiner, CE
Guerreiro, MM
Marques-De-Faria, AP
Lopes-Cendes, I
TI Laboratorial diagnosis of fragile-X syndrome - Experience in a sample of
individuals with pervasive developmental disorders
SO ARQUIVOS DE NEURO-PSIQUIATRIA
LA English
DT Article
DE PCR; molecular diagnosis; FRAXA; autism; mental retardation; pervasive
developmental disorders
ID CHROMOSOME; REPEAT; FRAXA; DNA; METHYLATION; INSTABILITY; MUTATIONS;
FMR1; SITE; POPULATION
AB Fragile X syndrome is a frequent genetic disease associated to developmental disorders, including learning disability, mental retardation, behavioral problems and pervasive developmental disorders (autism and related conditions). We studied a sample of 82 individuals (69 males and 13 females) presenting with pervasive developmental disorders using three techniques for the diagnosis of fragile X syndrome (FXS). Cytogenetic analysis detected the fragile site in four males, but only one showed a consistent positive rate. Molecular study based on the PCR technique was inconclusive for most females (92.3%), which where latter submitted to Southern blotting analysis, and for one male (1.4%), excluding the FRAXA mutation in the remaining male individuals (98.6%). Molecular tests using the Southern blotting technique confirmed only one positive case (1.2%) in a male subject. These results showed that Southern blotting analysis of the FRAXA mutation has the best sensitivity and specificity for the diagnosis of FXS but also validated the PCR technique as a confinable screening test.
C1 UNICAMP, FCM, Dept Med Genet, BR-13084971 Campinas, SP, Brazil.
UNICAMP, FCM, Dept Neurol, BR-13084971 Campinas, SP, Brazil.
RP Lopes-Cendes, I (reprint author), UNICAMP, FCM, Dept Med Genet, Caixa Postal 9111, BR-13084971 Campinas, SP, Brazil.
EM icendes@unicamp.br
RI Lopes-Cendes, Iscia/B-9416-2013; Steiner, Carlos/B-9319-2014
OI Lopes-Cendes, Iscia/0000-0002-6221-6822; Steiner,
Carlos/0000-0001-5148-3063
CR BUNDEY S, 1994, DEV MED CHILD NEUROL, V36, P736
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NR 25
TC 2
Z9 3
PU ASSOC ARQUIVOS DE NEURO- PSIQUIATRIA
PI SAO PAULO SP
PA PR AMADEU AMARAL 47/33, 01327-010 SAO PAULO SP, BRAZIL
SN 0004-282X
J9 ARQ NEURO-PSIQUIAT
JI Arq. Neuro-Psiquiatr.
PD SEP
PY 2005
VL 63
IS 3A
BP 564
EP 570
DI 10.1590/S0004-282X2005000400002
PG 7
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA 961NU
UT WOS:000231669900002
PM 16172701
ER
PT J
AU Evans, J
AF Evans, J
TI Autism and Asperger syndrome: Preparing for adulthood, 2nd edition
SO BRITISH JOURNAL OF EDUCATIONAL PSYCHOLOGY
LA English
DT Book Review
CR Howlin P, 2004, AUTISM ASPERGER SYND
NR 1
TC 0
Z9 0
PU BRITISH PSYCHOLOGICAL SOC
PI LEICESTER
PA ST ANDREWS HOUSE, 48 PRINCESS RD EAST, LEICESTER LE1 7DR, LEICS, ENGLAND
SN 0007-0998
J9 BRIT J EDUC PSYCHOL
JI Br. J. Educ. Psychol.
PD SEP
PY 2005
VL 75
BP 517
EP 518
DI 10.1348/000709906X106246
PN 3
PG 2
WC Psychology, Educational
SC Psychology
GA 976EL
UT WOS:000232715500013
ER
PT J
AU Phillips, PH
Fray, KJ
Brodsky, MC
AF Phillips, PH
Fray, KJ
Brodsky, MC
TI Intermittent exotropia increasing with near fixation: a "soft'' sign of
neurological disease
SO BRITISH JOURNAL OF OPHTHALMOLOGY
LA English
DT Article
ID CONVERGENCE INSUFFICIENCY; OCULAR MOTILITY
AB Aim: To examine the association of distance- near disparity with neurological disease in children with intermittent exotropia.
Methods: A retrospective analysis was performed of the medical records of all children with intermittent exotropia examined at the Arkansas Children's Hospital between 1989 and 2002. The study group consisted of children with intermittent exotropia who had a near deviation that exceeded the deviation at distance by at least 10 prism dioptres. The control group consisted of children with intermittent exotropia who had a distance deviation greater than or equal to the deviation at near. The main outcome measure was the prevalence of neurological abnormalities in the study and control groups.
Results: Among the 29 patients in the study group, 19 ( 66%) had a history of concurrent neurological abnormalities. Associated neurological conditions included developmental delay ( 10 patients), attention deficit disorder ( four patients), cerebral palsy ( four patients), history of intracranial haemorrhage ( four patients), periventricular leucomalacia ( three patients), seizures ( two patients), cortical visual impairment ( two patients), hydrocephalus ( one patient), history of anoxic brain damage ( one patient), history of encephalitis ( one patient), and autism ( one patient). Among the 37 patients in the control group, seven ( 19%) had a history of concurrent neurological abnormalities. The difference in the prevalence of neurological disease between the study group and the control group was significant ( p = 0.0002).
Conclusion: Intermittent exotropia increasing with near fixation is associated with neurological disease in children.
C1 Univ Arkansas Med Sci, Dept Ophthalmol, Little Rock, AR 72205 USA.
Univ Arkansas Med Sci, Dept Pediat, Little Rock, AR 72205 USA.
RP Phillips, PH (reprint author), Arkansas Childrens Hosp, 800 Marshall St, Little Rock, AR 72202 USA.
EM phillipspaulh@uams.edu
CR ALQURAINY IA, 1995, BR J ORAL MAXILLOFAC, V32, P71
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Stavis Monte, 2002, Binocul Vis Strabismus Q, V17, P135
NR 14
TC 7
Z9 7
PU B M J PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 0007-1161
J9 BRIT J OPHTHALMOL
JI Br. J. Ophthalmol.
PD SEP
PY 2005
VL 89
IS 9
BP 1120
EP 1122
DI 10.1136/bjo.2004.063123
PG 3
WC Ophthalmology
SC Ophthalmology
GA 956PW
UT WOS:000231313300015
PM 16113363
ER
PT J
AU Hansson, SL
Rojvall, AS
Rastam, M
Gillberg, C
Gillberg, C
Anckarsater, H
AF Hansson, SL
Rojvall, AS
Rastam, M
Gillberg, C
Gillberg, C
Anckarsater, H
TI Psychiatric telephone interview with parents for screening of childhood
autism-tics, attention-deficit hyperactivity disorder and other
comorbidities (A-TAC) - Preliminary reliability and validity
SO BRITISH JOURNAL OF PSYCHIATRY
LA English
DT Article
ID DIAGNOSTIC INTERVIEW; ASPERGER-SYNDROME; COMMUNICATION DISORDERS;
FUNCTIONING AUTISM; QUESTIONNAIRE; ADHD
AB Background Reliable, valid and easily administered screening instruments would greatly facilitate large-scale neuropsychiatric research.
Aims To testa parent telephone interview focused on autism-tics, attention-deficit hyperactivity disorder (ADHD) and other comorbidities (A-TAC).
Method Parents of 84 children in contact with a child neuropsychiatric clinic and 27 control children were interviewed. Validity and interrater and test-retest reliability were assessed.
Results Interrater and test-retest reliability were very good. Areas under receiver operating characteristics curves between interview scores and clinical diagnoses were around 0.90 for ADHD and autistic spectrum disorders, and above 0.70 for tics, learning disorders and developmental coordination disorder. Using optimal cut-off scores for autistic spectrum disorder and ADHD, good to excellent kappa levels for interviews and clinical diagnoses were noted.
Conclusions The A-TAC appears to be a reliable and valid instrument for identifying autistic spectrum disorder, ADHD, tics, learning disorders and developmental coordination disorder.
Declaration of interest None. Funding detailed in Acknowledgements.
C1 Gothenburg Univ, Dept Child & Adolescent Psychiat, S-41124 Gothenburg, Sweden.
Univ London St Georges Hosp, Sch Med, London SW17 0RE, England.
Gothenburg Univ, Inst Clin Neurosci, Dept Forens Psychiat, S-41124 Gothenburg, Sweden.
RP Anckarsater, H (reprint author), Malmo Univ Hosp, Forens Psychiat Clin, Sege Pk 8A, S-20502 Malmo, Sweden.
EM henrik.anckarsater@skane.se; henrik.anckarsater@skane.se
RI Anckarsater, Henrik/C-2244-2009
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NR 22
TC 62
Z9 62
PU ROYAL COLLEGE OF PSYCHIATRISTS
PI LONDON
PA BRITISH JOURNAL OF PSYCHIATRY 17 BELGRAVE SQUARE, LONDON SW1X 8PG,
ENGLAND
SN 0007-1250
J9 BRIT J PSYCHIAT
JI Br. J. Psychiatry
PD SEP
PY 2005
VL 187
BP 262
EP 267
DI 10.1192/bjp.187.3.262
PG 6
WC Psychiatry
SC Psychiatry
GA 965EE
UT WOS:000231932200011
PM 16135864
ER
PT J
AU Price, A
AF Price, A
TI Autism and Asperger syndrome: Preparing for adulthood, 2nd edition.
SO BRITISH JOURNAL OF PSYCHIATRY
LA English
DT Book Review
C1 Maudsley Hosp & Inst Psychiat, Autism & Related Disorders Clin, London SE5 8AZ, England.
RP Price, A (reprint author), Maudsley Hosp & Inst Psychiat, Autism & Related Disorders Clin, Denmark Hill, London SE5 8AZ, England.
CR Howlin P, 2004, AUTISM ASPERGER SYND
NR 1
TC 0
Z9 0
PU ROYAL COLLEGE OF PSYCHIATRISTS
PI LONDON
PA BRITISH JOURNAL OF PSYCHIATRY 17 BELGRAVE SQUARE, LONDON SW1X 8PG,
ENGLAND
SN 0007-1250
J9 BRIT J PSYCHIAT
JI Br. J. Psychiatry
PD SEP
PY 2005
VL 187
BP 295
EP 295
DI 10.1192/bjp.187.3.295
PG 1
WC Psychiatry
SC Psychiatry
GA 965EE
UT WOS:000231932200032
ER
PT J
AU Palazzi, S
AF Palazzi, S
TI Autism and blindness. Research and reflections
SO BRITISH JOURNAL OF PSYCHIATRY
LA English
DT Book Review
C1 Michael Rutter Ctr Children & Young People, London SE5 8AZ, England.
RP Palazzi, S (reprint author), Michael Rutter Ctr Children & Young People, De Crespigny Pk, London SE5 8AZ, England.
CR Baron-Cohen Simon, 1995, MINDBLINDNESS ESSAY
Pring L., 2005, AUTISM BLINDNESS RES
Rutter M, 1999, J CHILD PSYCHOL PSYC, V40, P537, DOI 10.1017/S0021963099003935
NR 3
TC 0
Z9 0
PU ROYAL COLLEGE OF PSYCHIATRISTS
PI LONDON
PA BRITISH JOURNAL OF PSYCHIATRY 17 BELGRAVE SQUARE, LONDON SW1X 8PG,
ENGLAND
SN 0007-1250
J9 BRIT J PSYCHIAT
JI Br. J. Psychiatry
PD SEP
PY 2005
VL 187
BP 296
EP 296
DI 10.1192/bjp.187.3.296
PG 1
WC Psychiatry
SC Psychiatry
GA 965EE
UT WOS:000231932200034
ER
PT J
AU Laurence, JA
Fatemi, SH
AF Laurence, JA
Fatemi, SH
TI Glial fibrillary acidic protein is elevated in superior frontal,
parietal and cerebellar cortices of autistic subjects
SO CEREBELLUM
LA English
DT Article
DE GFAP; Autism; schizophrenia; western blotting; cerebellum
ID INFECTION IN-UTERO; BRAINS; CORTEX; BCL-2; CHILDREN; MICE
AB Autism is a debilitating neurodevelopmental disorder of early childhood with both genetic and environmental origins. Immune system dysregulation has been hypothesized to be involved in this disorder. We quantified levels of glial fibrillary acidic protein (GFAP) and beta-actin in three areas of the brain, namely, area 9, area 40 and cerebellum, in age matched autistic and control postmortem specimen using SDS-PAGE and western blotting techniques. Significant elevations in levels of GFAP were observed in all three brain areas in autism. This report confirms a recent report showing microglial and astroglial activation in autism. Increased GFAP levels in autistic brains signify gliosis, reactive injury, and perturbed neuronal migration processes.
C1 Univ Minnesota, Sch Med, Div Neurosci Res, Minneapolis, MN 55455 USA.
RP Fatemi, SH (reprint author), Univ Minnesota, Sch Med, Dept Psychiat, Div Neurosci, MMC 392,420 Delaware St SE, Minneapolis, MN 55455 USA.
EM fatem002@umn.edu
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NR 20
TC 66
Z9 68
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 1473-4222
J9 CEREBELLUM
JI Cerebellum
PD SEP
PY 2005
VL 4
IS 3
BP 206
EP 210
DI 10.1080/14734220500208846
PG 5
WC Neurosciences
SC Neurosciences & Neurology
GA 970RT
UT WOS:000232328000007
PM 16147953
ER
PT J
AU Evans, DW
Canavera, K
Kleinpeter, FL
Maccubbin, E
Taga, K
AF Evans, David W.
Canavera, Kristin
Kleinpeter, F. Lee
Maccubbin, Elise
Taga, Ken
TI The fears, phobias and anxieties of children with autism spectrum
disorders and down syndrome: Comparisons with developmentally and
chronologically age matched children
SO CHILD PSYCHIATRY & HUMAN DEVELOPMENT
LA English
DT Article
DE anxiety; fears; autism spectrum disorders; down syndrome
AB This study compared the fears and behavior problems of 25 children with an autism spectrum disorder (ASD), 43 children with Down syndrome (DS), 45 mental age (MA) matched children, and 37 chronologically age (CA) matched children. Children's fears, phobias, anxieties and behavioral problems were assessed using parent reports. Significant differences emerged across the diagnostic groups on a variety of fears. Children with ASD were reported to have more situation phobias and medical fears, but fewer fears of harm/injury compared to all other groups. The groups also differed in terms of the pattern of correlations between fears, phobias, anxieties and behavior problems. For children with ASD, fears, phobias and anxieties were closely related to problem behaviors, whereas fears, phobias, and anxieties were less related to behavioral symptoms for the other groups of subjects. Such findings suggest that children with ASD exhibit a distinct pro. le of fear and anxiety compared to other mental age and chronologically age-matched children, and these fears are related to the symptoms associated with ASD.
C1 [Evans, David W.; Canavera, Kristin; Taga, Ken] Bucknell Univ, Dept Psychol, Lewisburg, PA 17837 USA.
[Maccubbin, Elise] Univ New Orleans, Dept Psychol, New Orleans, LA 70148 USA.
RP Evans, DW (reprint author), Bucknell Univ, Dept Psychol, Lewisburg, PA 17837 USA.
EM dwevans@bucknell.edu
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NR 36
TC 66
Z9 67
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0009-398X
J9 CHILD PSYCHIAT HUM D
JI Child Psychiat. Hum. Dev.
PD SEP
PY 2005
VL 36
IS 1
BP 3
EP 26
DI 10.1007/s10578-004-3619-x
PG 24
WC Psychology, Developmental; Pediatrics; Psychiatry
SC Psychology; Pediatrics; Psychiatry
GA V44NU
UT WOS:000203010200001
PM 16049642
ER
PT J
AU Mulder, EJ
Oosterloo-Duinkerken, A
Anderson, GM
De Vries, EGE
Minderaa, RB
Kema, IP
AF Mulder, EJ
Oosterloo-Duinkerken, A
Anderson, GM
De Vries, EGE
Minderaa, RB
Kema, IP
TI Automated on-line solid-phase extraction coupled with HPLC for
measurement of 5-hydroxyindole-3-acetic acid in urine
SO CLINICAL CHEMISTRY
LA English
DT Article
ID MASS-SPECTROMETRIC METHOD; PLATELET SEROTONIN; CARCINOID-TUMORS;
WHOLE-BLOOD; TRYPTOPHAN; DISORDERS; INDOLES; AUTISM
AB Background: Quantification of 5-hydroxyindole-3-acetic acid (5-HIAA) in urine is useful in diagnosing and monitoring of patients with carcinoid tumors and in the study of serotonin (5-hydroxytryptamine) metabolism in various disorders. We describe an automated method that incorporates on-line solid-phase extraction (SPE) and HPLC to measure urinary 5-HIAA.
Methods: Automated prepurification of urine was accomplished with HySphere-resin GP SPE cartridges containing strong hydrophobic polystyrene resin. The analyte (5-HIAA) and internal standard [5-hydroxyindole-3-carboxylic acid (5-HICA)] were eluted from the SPE cartridge, separated by reversed-phase HPLC, and detected fluorometrically with a total cycle time of 20 min. Urinary excretion of 5-HIAA was measured in a group of patients with known and suspected carcinoid tumors (n = 63) and in 20 patients with autism.
Results: The internal standard (5-HICA) and 5-HIAA were recovered in high yields (87.2%-114%). Within- and between-series CVs for the measurement of 5-HIAA in urine ranged from 1.2% to 3.9% and 3.2% to 7.6%, respectively. For urine samples from patients with known or suspected carcinoid tumors, results obtained by the automated method were highly correlated Q = 0.988) with those from an established manual extraction method. For samples from autistic patients, urinary excretion of 5-HIAA was similar to that reported for healthy individuals.
Conclusion: This SPE-HPLC method demonstrated lower imprecision and time per analysis than the manual solvent extraction method. (C) 2005 American Association for Clinical Chemistry.
C1 Univ Groningen, Univ Med Ctr Groningen, Dept Pathol & Lab Med, NL-9700 RB Groningen, Netherlands.
Univ Groningen, Univ Med Ctr Groningen, Dept Med Oncol, NL-9700 RB Groningen, Netherlands.
Yale Univ, Sch Med, Ctr Child Study, New Haven, CT 06510 USA.
RP Kema, IP (reprint author), Univ Groningen, Univ Med Ctr Groningen, Dept Pathol & Lab Med, POB 30-001, NL-9700 RB Groningen, Netherlands.
EM i.p.kema@lc.umcg.nl
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NR 18
TC 23
Z9 23
PU AMER ASSOC CLINICAL CHEMISTRY
PI WASHINGTON
PA 2101 L STREET NW, SUITE 202, WASHINGTON, DC 20037-1526 USA
SN 0009-9147
J9 CLIN CHEM
JI Clin. Chem.
PD SEP
PY 2005
VL 51
IS 9
BP 1698
EP 1703
DI 10.1373/clinchem.2005.050062
PG 6
WC Medical Laboratory Technology
SC Medical Laboratory Technology
GA 959RF
UT WOS:000231535100020
PM 16020500
ER
PT J
AU Salgado-Pineda, P
Delaveau, P
Blin, O
Nieoullon, A
AF Salgado-Pineda, P
Delaveau, P
Blin, O
Nieoullon, A
TI Dopaminergic contribution to the regulation of emotional perception
SO CLINICAL NEUROPHARMACOLOGY
LA English
DT Review
DE dopamine; emotional process; dopaminergic limbic system
ID MEDIAL PREFRONTAL CORTEX; SUBTHALAMIC NUCLEUS STIMULATION; DEFICIT
HYPERACTIVITY DISORDER; FACIAL-AFFECT RECOGNITION; PARKINSONS-DISEASE;
HUNTINGTONS-DISEASE; SCHIZOPHRENIC-PATIENTS; LOCOMOTOR-ACTIVITY;
NEGATIVE SYMPTOMS; MONKEY STRIATUM
AB Dopamine (DA) acts as a key neurotransmitter in the brain. Numerous studies have shown its regulatory role in motor and cognitive function. However, the impairment of emotional processes-in neurologic and psychiatric pathologies involving the dopaminergic system (Parkinson disease, schizophrenia, autism, Attention Deficit Hyperactivity Disorder, Huntington disease, frontal lobe lesions), as well as the influence that administration of dopaminergic agonists/antagonists exert on the processing of emotion, Suggest a role for DA in emotional processes. Moreover, emotional processes are dependent upon a variety of structures, the majority of which form part of the limbic system and are subject to DA innervation. In reviewing the literature, the amygdala emerges as a brain structure critical for emotional processing. It may also be implicated in deficits in emotional recognition found in two major disorders where DA's implication is clear: Parkinson disease and schizophrenia. In addition, the amygdala's response to emotional tasks is likely to be altered by the administration of both agonist and antagonist dopaminergic drugs. Experimental studies reinforce the idea of a dopaminergic contribution to emotional response, as suggested by biochemical, pharmacologic, and lesion experiments. Although the implication of the dopaminergic system in emotional processing appears to be clearly documented. the contribution of specific DA receptor subtypes, or of the DA cotransmitters cholecystokinin and neurotensin, or even glutamate, is, however, still unclear. Altogether, these observations suggest that DA has, undoubtedly, a direct and/or indirect role in the full emotional process.
C1 CNRS, IC2N, UMR 6186, Marseille, France.
Univ Mediterranee, Inst Neurosci Cognit Mediterranee, Fac Med, CNRS,UMR 6193, Marseille, France.
RP Blin, O (reprint author), Univ Mediterranee, UPCET, Univ Praticien Hosp, F-13385 Marseille, France.
EM olivier.blin@ap-hm.fr
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NR 108
TC 61
Z9 61
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3261 USA
SN 0362-5664
J9 CLIN NEUROPHARMACOL
JI Clin. Neuropharmacol.
PD SEP-OCT
PY 2005
VL 28
IS 5
BP 228
EP 237
DI 10.1097/01.wnf.0000185824.57690.f0
PG 10
WC Clinical Neurology; Pharmacology & Pharmacy
SC Neurosciences & Neurology; Pharmacology & Pharmacy
GA 981HA
UT WOS:000233077100005
PM 16239763
ER
PT J
AU Fein, D
AF Fein, D
TI Recovery in autism: Does it occur? What does it mean?
SO CLINICAL NEUROPSYCHOLOGIST
LA English
DT Meeting Abstract
NR 0
TC 0
Z9 0
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA
SN 1385-4046
J9 CLIN NEUROPSYCHOL
JI Clin. Neuropsychol.
PD SEP-DEC
PY 2005
VL 19
IS 3-4
BP 546
EP 547
PG 2
WC Psychology, Clinical; Clinical Neurology; Psychology
SC Psychology; Neurosciences & Neurology
GA 953XR
UT WOS:000231119200060
ER
PT J
AU Tervo, RC
AF Tervo, RC
TI Parent's reports predict their child's developmental problems
SO CLINICAL PEDIATRICS
LA English
DT Article
ID SOCIAL-EMOTIONAL DEVELOPMENT; DEVELOPMENT INVENTORY; MENTAL-RETARDATION;
BEHAVIOR PROBLEMS; NATIONAL-SURVEY; YOUNG-CHILDREN; CARE; DELAYS;
AUTISM; AGE
AB To document parental reports about their child ' s delayed development, 180 consecutive parents/ guardians of children, ages ranging from 16 to 70 months, were surveyed. Parents reported a mean of 8.28 (SD 4.55) problems. Symptoms most reported were not talking well (79.5%), poor speech (59.8%), immaturity (58.0%), understands poorly (55.4%), bowel/bladder problems (50.9%), seldom plays with others (47.3%), attention (46.4%), eating (43.8%), clumsy-gross motor (40.2%), and clumsy-fine motor (40.2%). There was an association between delayed development and symptoms about eating, bowel-bladder, clumsy fine-motor, not talking well, understands poorly, immature, and seldom plays with others (p < 0.05). The presence of language symptoms increased the odds of delayed development by 2.25. Relevant symptoms differed by developmental domains and different groups of items predicted specific delays. Parent reports indicated quantifiable difficulties requiring detailed assessments.
C1 Gillette Childrens Special Healthcare, St Paul, MN 55101 USA.
Univ Minnesota, Dept Pediat, Minneapolis, MN 55455 USA.
RP Tervo, RC (reprint author), Gillette Childrens Special Healthcare, 200 E Univ Ave, St Paul, MN 55101 USA.
CR Achenbach T, 2000, MANUAL ASEBA PRESCHO
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NR 52
TC 19
Z9 20
PU WESTMINSTER PUBL INC
PI GLEN HEAD
PA 708 GLEN COVE AVE, GLEN HEAD, NY 11545 USA
SN 0009-9228
J9 CLIN PEDIATR
JI Clin. Pediatr.
PD SEP
PY 2005
VL 44
IS 7
BP 601
EP 611
DI 10.1177/000992280504400708
PG 11
WC Pediatrics
SC Pediatrics
GA 961UL
UT WOS:000231687200008
PM 16151566
ER
PT J
AU Kellerman, GR
Fan, J
Gorman, JM
AF Kellerman, GR
Fan, J
Gorman, JM
TI Auditory abnormalities in autism: Toward functional distinctions among
findings
SO CNS SPECTRUMS
LA English
DT Review
ID BRAIN POTENTIALS; CHILDREN; IMPAIRMENT; LANGUAGE; PERCEPTION; DISORDERS;
SPEECH; INFORMATION; PERCEIVE; STIMULI
AB Recently, findings on a wide range of auditory abnormalities among individuals with autism have been reported. TO date, functional distinctions among these varied findings are poorly established. Such distinctions should be of interest to clinicians and researchers alike given their potential therapeutic and experimental applications. This review suggests three general trends among these findings as a starting point for future analyses. First, studies of auditory perception of linguistic and social auditory stimuli among individuals with autism generally have found impaired perception versus normal controls. Such findings may correlate with impaired language and communication skills and social isolation observed among individuals with autism. Second, studies of auditory perception of pitch and music among individuals with autism generally have found enhanced perception versus normal controls. These findings may correlate with the restrictive and highly focused behaviors observed among individuals with autism. Third, findings on the auditory perception of non-linguistic, non-musical stimuli among autism patients resist any generalized conclusions. Ultimately, as some researchers have already suggested, the distinction between impaired global processing and enhanced local processing may prove useful in making sense of apparently discordant findings on auditory abnormalities among individuals with autism.
C1 Mt Sinai Sch Med, Dept Psychiat, New York, NY USA.
RP Kellerman, GR (reprint author), 12 E 97th St 4B, New York, NY 10029 USA.
EM grosen@post.harvard.edu
RI Fan, Jin/A-6716-2009
OI Fan, Jin/0000-0001-9630-8330
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NR 46
TC 22
Z9 23
PU M B L COMMUNICATIONS, INC
PI NEW YORK
PA 333 HUDSON ST, 7TH FLOOR, NEW YORK, NY 10013 USA
SN 1092-8529
J9 CNS SPECTRUMS
JI CNS Spectr.
PD SEP
PY 2005
VL 10
IS 9
BP 748
EP 756
PG 9
WC Clinical Neurology; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA 974QP
UT WOS:000232606800013
PM 16142214
ER
PT J
AU Bjorne, P
Balkenius, C
AF Bjorne, P
Balkenius, C
TI A model of attentional impairments in autism: first steps toward a
computational theory
SO COGNITIVE SYSTEMS RESEARCH
LA English
DT Article; Proceedings Paper
CT Symposium on Three-Dimensional Sensory and Motor Space
CY OCT 08-13, 2005
CL Sant Feliu de Guixols, SPAIN
SP ESF-EMBO
DE autism; attention; computational model
ID SPATIAL ATTENTION; CEREBELLUM
AB A computational model with three interacting components for context sensitive reinforcement learning, context processing and automation can autonomously learn a focus attention and a shift attention task. The performance of the model is similar to that of normal children, and when a single parameter is changed, the performance on the two tasks approaches that of autistic children. (c) 2004 Elsevier B.V. All rights reserved.
C1 Lund Univ Cognit Sci, S-22222 Lund, Sweden.
RP Bjorne, P (reprint author), Lund Univ Cognit Sci, S-22222 Lund, Sweden.
EM petra.bjorne@lucs.lu.se
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NR 45
TC 6
Z9 6
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1389-0417
J9 COGN SYST RES
JI Cogn. Syst. Res.
PD SEP
PY 2005
VL 6
IS 3
BP 193
EP 204
DI 10.1016/j.cogsys.2004.11.003
PG 12
WC Computer Science, Artificial Intelligence; Neurosciences; Psychology,
Experimental
SC Computer Science; Neurosciences & Neurology; Psychology
GA 006GK
UT WOS:000234884300002
ER
PT J
AU Ben Shalom, D
AF Ben Shalom, D
TI Autism and the experience of a perceptual object
SO CONSCIOUSNESS AND COGNITION
LA English
DT Editorial Material
DE autism; object recognition; medial prefrontal cortex
ID CORTEX; ATTENTION; EMOTION; TASK
AB Sewards and Sewards (2002) argue that while computations necessary for object recognition occur throughout the ventral visual stream, object recognition awareness involves the anterior temporal lobe and the medial orbital prefrontal cortex. The present paper suggests, however, that the medial orbital prefrontal cortex has a unique contribution, namely that of producing a basic experience of a perceptual object. It is further argued that the mechanisms that produce this experience also result in making the object more important than its subparts and features. Finally, it is argued that a reduction in this importance may account for some perceptual difficulties in high-functioning autism. This view is consistent with evidence for early selective abnormalities in other systems involving the medial prefrontal cortex in autism. (c) 2005 Elsevier Inc. All rights reserved.
C1 Ben Gurion Univ Negev, Zlotowski Ctr Neurosci, Dept Foreign Literatures & Linguist, IL-84105 Beer Sheva, Israel.
RP Ben Shalom, D (reprint author), Ben Gurion Univ Negev, Zlotowski Ctr Neurosci, Dept Foreign Literatures & Linguist, IL-84105 Beer Sheva, Israel.
EM doritb@bgumail.bgu.ac.il
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NR 20
TC 1
Z9 1
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 1053-8100
J9 CONSCIOUS COGN
JI Conscious. Cogn.
PD SEP
PY 2005
VL 14
IS 3
BP 641
EP 644
DI 10.1016/j.concog.2005.03.005
PG 4
WC Psychology, Experimental
SC Psychology
GA 959AT
UT WOS:000231490000015
ER
PT J
AU Mohr, C
Gray, KM
AF Mohr, C
Gray, KM
TI Assessment in intellectual disability
SO CURRENT OPINION IN PSYCHIATRY
LA English
DT Article
DE assessment; autism; choice; intellectual disability; offending; pain;
preference; psychopathology; risk
ID DEVELOPMENTAL BEHAVIOR CHECKLIST; SEVERE COGNITIVE IMPAIRMENTS; MENTALLY
DISORDERED OFFENDERS; AUTISTIC SPECTRUM DISORDERS; PAS-ADD CHECKLIST;
SCREENING QUESTIONNAIRE; ACTUARIAL PREDICTION; DIAGNOSTIC INTERVIEW;
FINNISH CHILDREN; RISK-ASSESSMENT
AB Purpose of review This review examines an eclectic selection of publications from the past 12 months under the broad heading of 1 assessment in intellectual disability'. Being unable to cover all possible publications the authors have concentrated on the assessment of pain (in those with severe intellectual disability), psychopathology, risk assessment and offending, autism, preference and choice, and dementia.
Recent findings Research into assessment has generally taken the form of developing new instruments, or adapting existing ones, or comparing the performance of a range of scales in a certain area. Researchers are using increasingly sophisticated psychometric analyses and refining the nature and purpose of tools for a range of clinical purposes.
Summary The result of recent effort in this area is better instruments, often developed by experienced researchers who have been working in their chosen area of speciality for some years. It has been a very worthwhile period of extension and consolidation.
C1 Monash Univ, Ctr Dev Psychiat & Psychol, Capital & Coast Dist Hlth Board, Wellington, New Zealand.
Monash Univ, Ctr Med, Ctr Dev Psychiat & Psychol, Clayton, Vic 3168, Australia.
RP Mohr, C (reprint author), Monash Univ, Ctr Dev Psychiat & Psychol, Capital & Coast Dist Hlth Board, Haumietiketike,POB 50-233, Wellington, New Zealand.
EM caroline.mohr@med.monash.edu.au
RI Gray, Kylie/H-3345-2014
OI Gray, Kylie/0000-0001-6518-4240
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NR 59
TC 3
Z9 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0951-7367
J9 CURR OPIN PSYCHIATR
JI Curr. Opin. Psychiatr.
PD SEP
PY 2005
VL 18
IS 5
BP 476
EP 483
DI 10.1097/01.yco.0000179483.62391.12
PG 8
WC Psychiatry
SC Psychiatry
GA 958JZ
UT WOS:000231442200003
PM 16639104
ER
PT J
AU Petty, J
Oliver, C
AF Petty, J
Oliver, C
TI Self-injurious behaviour in individuals with intellectual disabilities
SO CURRENT OPINION IN PSYCHIATRY
LA English
DT Article
DE applied behaviour analysis; behavioural phenotype; intellectual
disability; intervention; self-injurious behaviour
ID PRADER-WILLI-SYNDROME; FUNCTIONAL-ANALYSIS; MENTAL-RETARDATION;
DEVELOPMENTAL-DISABILITIES; ADULTS; AGGRESSION; STIMULI; AUTISM; CHILD
AB Purpose of review In this paper we review literature published in 2004 on self-injurious behaviour in individuals with intellectual disabilities. Reviewed studies examine phenomenology and comorbidity, pharmacological and other interventions, genetic syndromes, and behavioural assessment and treatment.
Recent findings Key findings include the possible association between self-injury and impulse control and stereotyped behaviours. Reports on the use of pharmacological interventions provide little evidence for the use such interventions, although the findings of studies on naltrexone seem stronger. In the behavioural phenotype literature the predictors of self-injury in Prader-Willi syndrome are becoming more refined. The behaviour analysis literature reports further development of assessment methodology to cater for idiosyncratic functions and low-rate behaviours.
Summary Developments in the fields of applied behaviour analysis and genetic syndromes highlight the importance of tailored assessments and interventions. Evidence from the pharmacological literature suggests that although significant numbers of individuals are prescribed such interventions, the research evidence for their efficacy is, at best, weak.
C1 Univ Birmingham, Sch Psychol, Birmingham B15 2TT, W Midlands, England.
RP Oliver, C (reprint author), Univ Birmingham, Sch Psychol, Birmingham B15 2TT, W Midlands, England.
EM c.oliver@bham.ac.uk
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NR 26
TC 8
Z9 8
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0951-7367
J9 CURR OPIN PSYCHIATR
JI Curr. Opin. Psychiatr.
PD SEP
PY 2005
VL 18
IS 5
BP 484
EP 489
DI 10.1097/01.yco.0000179484.62391.dc
PG 6
WC Psychiatry
SC Psychiatry
GA 958JZ
UT WOS:000231442200004
PM 16639105
ER
PT J
AU Hagerman, RJ
Ono, MY
Hagerman, PJ
AF Hagerman, RJ
Ono, MY
Hagerman, PJ
TI Recent advances in fragile X: a model for autism and neurodegeneration
SO CURRENT OPINION IN PSYCHIATRY
LA English
DT Article
DE ataxia; autism; brain atrophy; dementia; FMR1; FMRP; fragile X syndrome;
FXS; FXTAS; neurodegeneration; tremor
ID MENTAL-RETARDATION PROTEIN; TREMOR/ATAXIA SYNDROME FXTAS; PREMUTATION
CARRIERS; FMR1 PREMUTATION; MOUSE MODEL; DEVELOPMENTAL DISORDERS;
SYNAPTIC PLASTICITY; CEREBELLAR-ATAXIA; SPECTRUM DISORDER; BEHAVIOR
PROFILE
AB Purpose of review This review will describe recent developments in the neurobiology of fragile X syndrome (FXS), the association between FXS and autism, and involvement in premutation carriers.
Recent findings Metabotropic glutamate receptor 5 (mGluR5)-coupled pathways are dysregulated in individuals with FXS and this is thought to relate to the FXS phenotype. The mGluR5 model suggests that mGluR5 antagonists, including downstream effectors such as lithium, could be useful for treating FXS. Two forms of clinical involvement associated with the fragile X mental retardation 1 (FMR1) gene, autism and fragile X-associated tremor/ataxia syndrome (FXTAS), have received additional attention during the past year. One study has found that approximately 30% of individuals with FXS have autism; those with autism have lowered cognitive abilities, language problems, and behavioral difficulties compared to those with FXS alone. Furthermore, evidence is mounting that autism also occurs in some young males who have premutation alleles. Finally, males and occasional females with premutation alleles may develop a neurological syndrome with aging that consists of tremor, ataxia, peripheral neuropathy, and cognitive deficits. Significant brain atrophy and white-matter disease is usually seen. This new disorder (FXTAS) is thought to be related to elevated levels of abnormal FMR1 mRNA.
Summary Full-mutation forms of the gene (> 200 repeats) can cause autism, learning disabilities, anxiety disorders, and mental retardation. Disorders associated with premutation forms of the gene (55-200 repeats) include, in addition to autism, FXTAS in older males and females, and premature ovarian failure.
C1 Univ Calif Davis, Med Ctr, MIND Inst, Dept Pediat, Sacramento, CA 95817 USA.
Univ Calif Davis, Sch Med, Dept Biochem & Mol Med, Sacramento, CA 95817 USA.
RP Hagerman, RJ (reprint author), Univ Calif Davis, Med Ctr, MIND Inst, Dept Pediat, 2825 50th St, Sacramento, CA 95817 USA.
EM randi.hagerman@ucdmc.ucdavis.edu
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NR 81
TC 61
Z9 64
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0951-7367
J9 CURR OPIN PSYCHIATR
JI Curr. Opin. Psychiatr.
PD SEP
PY 2005
VL 18
IS 5
BP 490
EP 496
DI 10.1097/01.yco.0000179485.39520.b0
PG 7
WC Psychiatry
SC Psychiatry
GA 958JZ
UT WOS:000231442200005
PM 16639106
ER
PT J
AU Kasari, C
Rotheram-Fuller, E
AF Kasari, C
Rotheram-Fuller, E
TI Current trends in psychological research on children with
high-functioning autism and Asperger disorder
SO CURRENT OPINION IN PSYCHIATRY
LA English
DT Article
DE Asperger syndrome; autism; autism diagnosis
ID PERVASIVE DEVELOPMENTAL DISORDER; SPECTRUM DISORDERS; COMMUNICATION;
INDIVIDUALS; LANGUAGE; MIND; NOS; AGE
AB Purpose of review This review explores current trends in the literature during 2004 on psychological studies of children with high-functioning autism and Asperger syndrome. Studies are reviewed that examine diagnostic dilemmas and methodological concerns, cognitive and social deficits, and interventions.
Recent findings There is considerable debate over the distinction between high-functioning autism and Asperger syndrome, but few studies find support for separate disorders. Most studies reviewed combine high-functioning autism and Asperger syndrome into an autism spectrum disorder group or study only one diagnostic group, either high-functioning autism or Asperger syndrome. Research into cognitive processes (specifically mentalizing) and social understanding (nonliteral language) continue to dominate research efforts. Current studies suggest specific weaknesses in many areas of nonliteral language, such as humor, irony, and teasing. Studies rely heavily on current theoretical explanations for deficits, namely the central coherence, social inference, and executive function theories, and varying levels of support were found for all three theories. Intervention and outcome studies lag behind experimental and theoretical studies, but two studies employed scientifically rigorous intervention designs with promising results.
Summary Children with high-functioning autism and Asperger syndrome have a great deal of potential with respect to long-term developmental outcomes, and yet they continue to be understudied and under-served in current intervention programs. Future studies are needed in developmental processes and outcomes in this population, and in the development of effective treatment strategies that have undergone scientifically rigorous testing.
C1 Univ Calif Los Angeles, Dept Educ & Informat Studies, Los Angeles, CA 90095 USA.
RP Kasari, C (reprint author), Univ Calif Los Angeles, Dept Educ & Informat Studies, Box 951521,3132B MH, Los Angeles, CA 90095 USA.
EM kasari@gseis.ucla.edu
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Sturm H, 2004, DEV MED CHILD NEUROL, V46, P444, DOI 10.1017/S0012162204000738
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VOLKMAR F, 1996, HDB AUTISM PERVASIVE, P5
Walker DR, 2004, J AM ACAD CHILD PSY, V43, P172, DOI 10.1097/01.chi.0000101375.03068.db
NR 25
TC 16
Z9 18
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0951-7367
J9 CURR OPIN PSYCHIATR
JI Curr. Opin. Psychiatr.
PD SEP
PY 2005
VL 18
IS 5
BP 497
EP 501
DI 10.1097/01.yco.0000179486.47144.61
PG 5
WC Psychiatry
SC Psychiatry
GA 958JZ
UT WOS:000231442200006
PM 16639107
ER
PT J
AU Ronald, A
Happe, F
Plomin, R
AF Ronald, A
Happe, F
Plomin, R
TI The genetic relationship between individual differences in social and
nonsocial behaviours characteristic of autism
SO DEVELOPMENTAL SCIENCE
LA English
DT Article
ID PERVASIVE DEVELOPMENTAL DISORDERS; REPETITIVE BEHAVIORS; SIBLING
INTERACTION; ASPERGER-SYNDROME; FAMILY-HISTORY; CHILDREN; TWIN;
PHENOTYPE; LINKAGE; BIAS
AB Two types of behaviours shown in children - those reflecting social impairment and nonsocial obsessive repetitive behaviours are central to defining and diagnosing autism spectrum disorders (ASDs). Parent and teacher data on social and nonsocial behaviours were obtained from a community sample of > 3000 7-year-old twin pairs. Social and nonsocial behaviours were only modestly correlated, and it was found that some individuals had extreme scores on either social or nonsocial scales but not both. Genetic model-fitting showed that social and nonsocial behaviours are both highly heritable, but their genetic overlap is modest, with most of the genetic influence being specific to either social or nonsocial behaviours. Considering these behaviours separately might help clarify gene-brain-behaviour pathways in future research.
C1 Kings Coll London, Inst Psychiat, Social Genet & Dev Psychiat Ctr, London SE5 8AF, England.
RP Ronald, A (reprint author), Kings Coll London, Inst Psychiat, Social Genet & Dev Psychiat Ctr, De Crespigny Pk,Box PO83, London SE5 8AF, England.
EM a.ronald@iop.kcl.ac.uk
RI Happe, Francesca/D-5544-2012; Ronald, Angelica/C-7812-2009; Plomin,
Robert/B-8911-2008
OI Ronald, Angelica/0000-0002-9576-2176;
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NR 59
TC 110
Z9 110
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 1363-755X
J9 DEVELOPMENTAL SCI
JI Dev. Sci.
PD SEP
PY 2005
VL 8
IS 5
BP 444
EP 458
DI 10.1111/j.1467-7687.2005.00433.x
PG 15
WC Psychology, Developmental; Psychology, Experimental
SC Psychology
GA 954TV
UT WOS:000231178700008
PM 16048517
ER
PT J
AU Dyches, TT
Prater, MA
AF Dyches, TT
Prater, MA
TI Characterization of developmental disability in children's fiction
SO EDUCATION AND TRAINING IN DEVELOPMENTAL DISABILITIES
LA English
DT Article; Proceedings Paper
CT 9th International Conference of the
Council-for-Exceptional-Children-Division-on-Developmental-Disabilities
CY OCT 10-12, 2004
CL Las Vegas, NV
SP Council Except Children Div Dev Disabilities
ID MENTAL-RETARDATION; AUTISM
AB Based on the Dyches and Prater (2000) guidelines, characterizations and plots in 34 eligible children's books published during 1999-2003 were evaluated; 36 characterizations are discussed in detail in terms Of each guideline. Results showed that, compared to a previous study (Dyches, Prater, & Cramer, 2001), characters with developmental disabilities made more deliberate choices, were educated in more inclusive settings, were more accepted in their communities, and served in more helping roles; and more commonly the disability was only one of many character traits. Also a wide age spectrum was portrayed, and several characterizations represented people from minority races or cultures. Over half of the characters with DD had autism spectrum disorders, and almost half of those characters had Asperger syndrome.
C1 Brigham Young Univ, Provo, UT 84602 USA.
RP Dyches, TT (reprint author), Brigham Young Univ, 340 F McKay Bldg, Provo, UT 84602 USA.
EM Tina_dyches@byu.edu
CR American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th
ARMITAGE D, 1999, MY BROTHER SAMMY
BANKS SH, 1997, SHADOW WINGS
BEARD DB, 2002, BABBS SWITCH STORY
Blaska Joan K., 2003, USING CHILDRENS LIT
BYRD LM, 2003, TREASURE GOLD STREET
CARTER AR, 1999, DUSTINS BIG SCH DAY
DUANE D, 2002, WIZARD ALONE
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2004, CHILDRENS BOOKS PRIN
NR 52
TC 4
Z9 4
PU COUNCIL EXCEPTIONAL CHILDREN
PI ARLINGTON
PA 1110 N GLEBE RD, ARLINGTON, VA 22201-5704 USA
SN 1547-0350
J9 EDUC TRAIN DEV DISAB
JI Educ. Train. Dev. Disabil.
PD SEP
PY 2005
VL 40
IS 3
BP 202
EP 216
PG 15
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA 960KN
UT WOS:000231589500002
ER
PT J
AU Loncola, JA
Craig-Unkefer, L
AF Loncola, JA
Craig-Unkefer, L
TI Teaching social communication skills to young urban children with autism
SO EDUCATION AND TRAINING IN DEVELOPMENTAL DISABILITIES
LA English
DT Article; Proceedings Paper
CT 9th International Conference of the
Council-for-Exceptional-Children-Division-on-Developmental-Disabilities
CY OCT 10-12, 2004
CL Las Vegas, NV
SP Council Except Children Div Dev Disabilities
ID MANAGEMENT TREATMENT PACKAGE; PLAY SKILLS; PEER; INTERVENTION;
INITIATIONS; BEHAVIOR; PRESCHOOLERS; MODEL
AB This study examined effects of an intervention designed to improve the social-communication skills of children with autism. Five boys and one girl, with an age range of six to eight years and a diagnosis of autism, participated in the study. Children were paired in dyads and a multiple baseline design was used to evaluate the effectiveness of the plan-play-report intervention. Unique because two children with autism received intervention at the same time, results indicated that the intervention was successful in increasing peer-directed commenting, language diversity, and complexity. Results of this study indicate that a plan-play-report intervention provided simultaneously to two children with autism is a viable method for improving the social communication skills of both children.
C1 De Paul Univ, Sch Educ, Chicago, IL 60614 USA.
Univ Minnesota, Minneapolis, MN 55455 USA.
RP Loncola, JA (reprint author), De Paul Univ, Sch Educ, 2320 N Kenmore, Chicago, IL 60614 USA.
CR Alvarez A., 1998, CHILD PSYCHOL PSYCHI, V3, P99, DOI 10.1017/S1360641798001579
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NR 42
TC 7
Z9 7
PU COUNCIL EXCEPTIONAL CHILDREN
PI ARLINGTON
PA 1110 N GLEBE RD, ARLINGTON, VA 22201-5704 USA
SN 1547-0350
J9 EDUC TRAIN DEV DISAB
JI Educ. Train. Dev. Disabil.
PD SEP
PY 2005
VL 40
IS 3
BP 243
EP 263
PG 21
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA 960KN
UT WOS:000231589500005
ER
PT J
AU Pierson, MR
Glaeser, BC
AF Pierson, MR
Glaeser, BC
TI Extension of research on social skills training using comic strip
conversations to students without autism
SO EDUCATION AND TRAINING IN DEVELOPMENTAL DISABILITIES
LA English
DT Article; Proceedings Paper
CT 9th International Conference of the
Council-for-Exceptional-Children-Division-on-Developmental-Disabilities
CY OCT 10-12, 2004
CL Las Vegas, NV
SP Council Except Children Div Dev Disabilities
ID LEARNING-DISABILITIES
AB Comic Strip Conversations is a positive behavioral support strategy that has been used effectively to improve the social skills of students with autism. Research on the effectiveness of this strategy was extended to four students with other mild/moderate learning, cognitive and behavioral disabilities. Two elementary teachers used Comic Strip Conversations for a period of six weeks with four 6-10 year olds who exhibited difficult social behaviors. All participants improved their perceptions of social situations, exhibited appropriate social growth, began to generate their own solutions to difficult social situations, and demonstrated a decrease in target behaviors.
C1 Calif State Univ Fullerton, Dept Special Educ, Fullerton, CA 92834 USA.
RP Pierson, MR (reprint author), Calif State Univ Fullerton, Dept Special Educ, POB 6868, Fullerton, CA 92834 USA.
EM mpierson@fullerton.edu
CR Atwood T., 2000, AUTISM INT J RES PRA, V4, P85
Glaeser B. C., 2003, TEACHING EXCEPTIONAL, V36, P14
Gray C., 1994, COMIC STRIP CONVERSA
Gray C., 1995, TEACHING CHILDREN AU, P219
Gray C.A., 1995, SOCIAL STORIES UNLIM
GRESHAM FM, 1992, SCHOOL PSYCHOL REV, V21, P348
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NR 12
TC 3
Z9 3
PU COUNCIL EXCEPTIONAL CHILDREN
PI ARLINGTON
PA 1110 N GLEBE RD, ARLINGTON, VA 22201-5704 USA
SN 1547-0350
J9 EDUC TRAIN DEV DISAB
JI Educ. Train. Dev. Disabil.
PD SEP
PY 2005
VL 40
IS 3
BP 279
EP 284
PG 6
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA 960KN
UT WOS:000231589500007
ER
PT J
AU Boutot, EA
Guenther, T
Crozier, S
AF Boutot, EA
Guenther, T
Crozier, S
TI Let's play: Teaching play skills to young children with autism
SO EDUCATION AND TRAINING IN DEVELOPMENTAL DISABILITIES
LA English
DT Article; Proceedings Paper
CT 9th International Conference of the
Council-for-Exceptional-Children-Division-on-Developmental-Disabilities
CY OCT 10-12, 2004
CL Las Vegas, NV
SP Council Except Children Div Dev Disabilities
ID INTERVENTION; PRESCHOOL; DISABILITIES; BEHAVIORS
AB Watch any young child and you will likely see him or her engaged in some form of play. Play is an integral part of early childhood development in which typically developing children learn social and language skills, as well as appropriate behaviors, problem solving, and a variety of other cognitive skills. By its very definition, autism is a disorder in which play is impaired or lacking, thus, many children with autism do not experience the natural benefits of play, as do their typical peers. Children with autism must be specifically taught to engage in social and play activities, and often require direct instruction to learn to play with others. Instruction in play skills is noted in the literature as important for young children with autism, yet little evidence suggests which of several teaching methods is most effective. This article describes several aspects of play, discusses various means of teaching play skills to children with autism, and makes suggestions for future research. Further, a case study, comparing the efficacy of two methods for play skills instruction is presented.
C1 De Paul Univ, Coll Educ, Chicago, IL 60614 USA.
Univ Nevada, Las Vegas, NV 89154 USA.
RP Boutot, EA (reprint author), De Paul Univ, Coll Educ, 2320 N Kenmore, Chicago, IL 60614 USA.
CR ALPERT CL, 1992, J EARLY INTERVENTION, V16, P31
American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th
Copple C., 1997, DEV APPROPRIATE PRAC
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NR 39
TC 11
Z9 11
PU COUNCIL EXCEPTIONAL CHILDREN
PI ARLINGTON
PA 1110 N GLEBE RD, ARLINGTON, VA 22201-5704 USA
SN 1547-0350
J9 EDUC TRAIN DEV DISAB
JI Educ. Train. Dev. Disabil.
PD SEP
PY 2005
VL 40
IS 3
BP 285
EP 292
PG 8
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA 960KN
UT WOS:000231589500008
ER
PT J
AU Zahir, F
Rizwi, SJ
Haq, SK
Khan, RH
AF Zahir, F
Rizwi, SJ
Haq, SK
Khan, RH
TI Low dose mercury toxicity and human health
SO ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
LA English
DT Review
DE mercury pollution; low dose toxicity; biomagnification;
neurodegenerative disorders
ID INORGANIC MERCURY; CHLORALKALI WORKERS; FISH CONSUMPTION; LOW EXPOSURE;
RAT-BRAIN; METHYLMERCURY CONCENTRATIONS; GLUTATHIONE DEPLETION;
BRAZILIAN AMAZON; NERVOUS-SYSTEM; TRACE-ELEMENTS
AB Post Minamata incident there has been awareness about mercury toxicity even among the general public. Previous researches contributed a vast amount of data regarding acute mercury exposure, but gradually information about the low dose [Ninomiya, T., Ohmori, H., Hashimoto, K., Tsuruta, K., Ekino, S., 1995. Expansion of methylmercury poisoning outside minamata: an epidemiological study on chronic methylmercury poisoninig outside of Minamata. Environ. Res. 70 (1) 47-50; Lebel, J., Mergler, D., Lucotte, M., Amorim, M., Dolbec, J., Miranda, D., Arantes, G., Rheault, L, Pichet, P., 1996. Evidence of early nervous system dysfunction in Amazonian populations exposed to low-levels of methylmercury. Neurotoxicology 17 (1) 157-167] of mercury toxicity has been trickling in. With mercury contaminating rain-, ground and sea-water no one is safe. Polluted water leads to mercury laced fish, meat and vegetable. In aquatic environments, inorganic mercury is microbiologically transformed into lipophilic organic compound 'methylmercury'. This transformation makes mercury more prone to biomagnification in food chains. Consequently, populations with traditionally high dietary intake of food originating from fresh or marine environment have highest dietary exposure to mercury. Extensive research done on locals across the globe have already established this, persons who routinely consume fish or a particular species of fish are at an increased risk of methylmercury poisoning. The easy access of the toxicant to man through multiple pathways air, water, food, cosmetic products and even vaccines increase the exposure. Foetus and children are more susceptible towards mercury toxicity. Mothers consuming diet containing mercury pass the toxicant to foetus and to infants through breast milk. Decreased performance in areas of motor function and memory has been reported among children exposed to presumably safe mercury levels. Similarly, disruption of attention, fine motor function and verbal memory was also found in adults on exposure to low mercury levels. It is an occupational hazard for dental staff, chloralkali factory workers and goldminers, etc. Mercury has been found to be a causative agent of various sorts of disorders, including neurological, nephrological, immunological, cardiac, motor, reproductive and even genetic. Recently heavy metal mediated toxicity has been linked to diseases like Alzeihemer's, Parkinson's, Autism, Lupus, Amyotrophic lateral sclerosis, etc. Besides this, it poses danger to wildlife. Therefore, it becomes imperative to spread the information regarding the threat of mercury exposure amongst the scientists and masses.
C1 AMU, JN Med Coll, Interdisciplinary Brain Res Ctr, Aligarh, Uttar Pradesh, India.
AMU, Interdisciplinary Biotechnol Unit, Aligarh, Uttar Pradesh, India.
RP Zahir, F (reprint author), AMU, JN Med Coll, Interdisciplinary Brain Res Ctr, Aligarh, Uttar Pradesh, India.
EM farhanazahir@rediffmail.com
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1999, HINDUSTAN TIMES 0902
NR 102
TC 236
Z9 263
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1382-6689
J9 ENVIRON TOXICOL PHAR
JI Environ. Toxicol. Pharmacol.
PD SEP
PY 2005
VL 20
IS 2
BP 351
EP 360
DI 10.1016/j.etap.2005.03.007
PG 10
WC Environmental Sciences; Pharmacology & Pharmacy; Toxicology
SC Environmental Sciences & Ecology; Pharmacology & Pharmacy; Toxicology
GA 961QK
UT WOS:000231676700015
PM 21783611
ER
PT J
AU Zaroff, CM
Isaacs, K
AF Zaroff, CM
Isaacs, K
TI Neurocutaneous syndromes: Behavioral features
SO EPILEPSY & BEHAVIOR
LA English
DT Review
DE neurocutaneous; tuberous sclerosis; Sturge-Weber; neurofibromatosis;
epilepsy; cognitive; autism
ID STURGE-WEBER-SYNDROME; TUBEROUS SCLEROSIS COMPLEX; UNIDENTIFIED BRIGHT
OBJECTS; OPTIC PATHWAY TUMORS; NEUROFIBROMATOSIS TYPE-1;
LEARNING-DISABILITY; EPILEPSY SURGERY; NATURAL-HISTORY;
NEUROPSYCHOLOGICAL FUNCTION; CLINICAL MANIFESTATIONS
AB Neurocutaneous syndromes are disorders charactertized by a neurological abnormality and cutaneous manifestations. Three of the more common neurocutaneous syndromes are Sturge-Weber syndrome, tuberous sclerosis, and neurofibromatosis. This review focuses on the cognitive and behavioral features of these syndromes. (c) 2005 Elsevier Inc. All rights reserved.
C1 NYU, Comprehens Epilepsy Ctr, New York, NY 10016 USA.
RP Zaroff, CM (reprint author), NYU, Comprehens Epilepsy Ctr, 403 E 34th St, New York, NY 10016 USA.
EM charles.zaroff@med.nyu.edu
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NR 113
TC 7
Z9 8
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 1525-5050
J9 EPILEPSY BEHAV
JI Epilepsy Behav.
PD SEP
PY 2005
VL 7
IS 2
BP 133
EP 142
DI 10.1016/j.yebeh.2005.05.012
PG 10
WC Behavioral Sciences; Clinical Neurology; Psychiatry
SC Behavioral Sciences; Neurosciences & Neurology; Psychiatry
GA 970UR
UT WOS:000232337300001
PM 15996528
ER
PT J
AU Phagava, H
Muratori, F
Maestro, S
Guzzetta, A
Cioni, G
AF Phagava, H.
Muratori, F.
Maestro, S.
Guzzetta, A.
Cioni, G.
TI Retrospective analysis of general movements in infants with autism
spectrum disorder: A pilot study
SO EUROPEAN JOURNAL OF NEUROLOGY
LA English
DT Meeting Abstract
C1 Georgian Acad Sci, Lab Child & Adolescent Hlth & Dev, GE-380060 Tbilisi, Rep of Georgia.
Stella Maris Sci Inst, Dept Dev Neurosci, Pisa, Italy.
NR 0
TC 0
Z9 0
PU BLACKWELL PUBLISHING
PI OXFORD
PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND
SN 1351-5101
J9 EUR J NEUROL
JI Eur. J. Neurol.
PD SEP
PY 2005
VL 12
SU 2
BP 239
EP 240
PG 2
WC Clinical Neurology; Neurosciences
SC Neurosciences & Neurology
GA V44GW
UT WOS:000202992200725
ER
PT J
AU Gilbert, MM
Auld, VJ
AF Gilbert, MM
Auld, VJ
TI Evolution of CLAMS (cholinesterase-like adhesion molecules): Structure
and function during development
SO FRONTIERS IN BIOSCIENCE
LA English
DT Article
DE junctions; adhesion; autism; synapse; acetylcholineasterse;
cholinesterase; review
ID TRANSMEMBRANE RECEPTOR NEUROTACTIN; HETEROPHILIC CELL-ADHESION;
PERIPHERAL ANIONIC SITE; DROSOPHILA NEUROTACTIN; HUMAN
ACETYLCHOLINESTERASE; INHIBITORY SYNAPSES; CRYSTAL-STRUCTURE; SERINE
ESTERASES; BINDING PROTEIN; PROMOTING SITE
AB The protein family known as CLAMS (cholinesterase-like adhesion molecules) forms a novel class of heterophilic cell adhesion proteins. Family members are found through a wide range of metazoans and play a role during the development of multiple tissues. The majority of members of this family are transmembrane proteins with an extracellular domain that is conserved with cholinesterases including acetylcholinesterase. Yet all family members lack one or more of the residues that make up the catalytic triad necessary for enzymatic function. Therefore the conserved cholinesterase-like domain is not necessary for enzymatic function but does appear to play a role in heterophilic binding. CLAMS are expressed in a wide array of tissues and most family members appear to play a role in cell adhesion and junction formation. The development of junctions including septate junctions and synaptic junctions require CLAM family members such as Gliotactin and Neuroligins respectively. Modeling of the cholinesterase-like domain reveals that evolutionary changes to the binding pocket of the cholinesterase domain may produce a range of different ligand binding partners for CLAM family members. In this vein, previous chimera experiments and recent work has identified mutations in CLAM family members that affect the structure of the cholinesterase-like domain. These mutant forms affect protein function during the development of specialized junctions and confirm the role of the cholinesterase domain in mediating heterophilic binding.
C1 Univ British Columbia, Dept Zool, Cell Biol Grp, Vancouver, BC V6T 1Z4, Canada.
RP Auld, VJ (reprint author), Univ British Columbia, Dept Zool, Cell Biol Grp, 6270 Univ Blvd, Vancouver, BC V6T 1Z4, Canada.
EM auld@zoology.ubc.ca
RI Auld, Vanessa/C-7829-2012
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NR 70
TC 21
Z9 22
PU FRONTIERS IN BIOSCIENCE INC
PI MANHASSET
PA C/O NORTH SHORE UNIV HOSPITAL, BIOMEDICAL RESEARCH CENTER, 350 COMMUNITY
DR, MANHASSET, NY 11030 USA
SN 1093-9946
J9 FRONT BIOSCI
JI Front. Biosci.
PD SEP 1
PY 2005
VL 10
SU S
BP 2177
EP 2192
DI 10.2741/1689
PG 16
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA 970OU
UT WOS:000232320300016
PM 15970486
ER
PT J
AU [Anonymous]
AF [Anonymous]
TI Fathers and autism
SO FUTURIST
LA English
DT Editorial Material
NR 0
TC 0
Z9 0
PU WORLD FUTURE SOC
PI BETHESDA
PA 7910 WOODMONT AVE, STE 450, BETHESDA, MD 20814 USA
SN 0016-3317
J9 FUTURIST
JI Futurist
PD SEP-OCT
PY 2005
VL 39
IS 5
BP 12
EP 12
PG 1
WC Social Issues
SC Social Issues
GA 951ZV
UT WOS:000230971800009
ER
PT J
AU LeBlanc, JC
Binder, CE
Armenteros, JL
Aman, MG
Wang, JS
Hew, H
Kusumakar, V
AF LeBlanc, JC
Binder, CE
Armenteros, JL
Aman, MG
Wang, JS
Hew, H
Kusumakar, V
TI Risperidone reduces aggression in boys with a disruptive behaviour
disorder and below average intelligence quotient: analysis of two
placebo-controlled randomized trials
SO INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY
LA English
DT Article
DE aggression; attention-deficit/hyperactivity disorder; atypical
antipsychotic; borderline intellectual functioning; conduct disorder;
disruptive behaviour disorders; mild mental retardation; oppositional
defiant disorder; risperidone
ID CONDUCT DISORDER; DOUBLE-BLIND; PROACTIVE AGGRESSION; RATING FORM;
CHILDREN; ADOLESCENTS; CLASSIFICATION; PHARMACOLOGY; PHENYTOIN; AUTISM
AB The present study aimed to analyse the effect of risperidone on a priori defined core aggression items. Data were pooled from 163 boys (aged 5-12 years, with or without comorbid attention-deficit/hyperactivity disorder) with a DSM-IV diagnosis of either conduct disorder or oppositional defiant disorder who had participated in either of two identical, 6-week, randomized, double-blind, placebo-controlled trials. All received treatment with either placebo or oral risperidone solution (0.01-0.06 mg/kg/ day). Subjects had below average intelligence [intelligence quotient (IQ) 36-84] and a score of >= 24 on the Conduct Problem subscale of the Nisonger Child Behaviour Rating Form (N-CBRF). An expert advisory panel selected six core aggression items from the N-CBRF, from which a total Aggression Score (AS, range 0-18) was constructed. Compared to those treated with placebo, risperidone-treated subjects experienced significantly greater mean decreases from baseline in the AS at each of weeks 1-6 (P < 0.001). By study endpoint, aggression among rispe rid one -treated subjects had declined by 56.4% (mean baseline AS 10.1; mean endpoint AS 4.4), which was more than twice that of placebo-treated subjects (mean baseline AS 10.6; mean endpoint AS 8.3; 21.7% reduction). Risperidone was efficacious in reducing symptoms of aggression in boys of below average IQ with disruptive behaviour disorders. Int Clin Psychopharmacol. (c) 2005 Lippincott Williams & Wilkins.
C1 IWK Hlth Ctr, Halifax, NS B35 6RB, Canada.
Dalhousie Univ, Dept Pediat, Halifax, NS, Canada.
Dalhousie Univ, Dept Psychiat, Halifax, NS, Canada.
Dalhousie Univ, Dept Community Hlth & Epidemiol, Halifax, NS, Canada.
Janssen Ortho Inc, Clin Affairs, Toronto, ON, Canada.
Miami Univ, Sch Med, Dept Psychiat, Miami, FL USA.
Miami Univ, Sch Med, Dept Pediat & Pediat Psychopharmacol, Miami, FL USA.
Ohio State Univ, Nisonger Ctr, Dept Psychol, Columbus, OH USA.
Ohio State Univ, Nisonger Ctr, Dept Psychiat, Columbus, OH USA.
Covar Inc, Mississauga, ON, Canada.
J&J Pharmaceut Res & Dev LLP, CNS Div, Titusville, NJ USA.
RP LeBlanc, JC (reprint author), IWK Hlth Ctr, 5850 Univ Ave, Halifax, NS B35 6RB, Canada.
EM john.leblanc@dal.ca
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NR 43
TC 18
Z9 18
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3261 USA
SN 0268-1315
J9 INT CLIN PSYCHOPHARM
JI Int. Clin. Psychopharmacol.
PD SEP
PY 2005
VL 20
IS 5
BP 275
EP 283
DI 10.1097/01.yic.0000166403.03732.72
PG 9
WC Pharmacology & Pharmacy; Psychiatry
SC Pharmacology & Pharmacy; Psychiatry
GA 978LK
UT WOS:000232874600005
PM 16096518
ER
PT J
AU Lerman, DC
Parten, M
Addison, LR
Vorndran, CM
Volkert, VM
Kodak, T
AF Lerman, DC
Parten, M
Addison, LR
Vorndran, CM
Volkert, VM
Kodak, T
TI A methodology for assessing the functions of emerging speech in children
with developmental disabilities
SO JOURNAL OF APPLIED BEHAVIOR ANALYSIS
LA English
DT Article
DE autism; communication training; developmental disabilities; functional
analysis; language; speech; verbal behavior
ID SELF-INJURIOUS-BEHAVIOR; VERBAL-BEHAVIOR; AUTISM; COMMUNICATION;
INTERVENTION; LANGUAGE
AB An approach based on Skinner's (1957) theory of verbal behavior has been developed to understand and teach elementary communication skills to children with autism and developmental disabilities (Sundberg & Partington, 1998). However, few studies have directly examined the characteristics of emerging language in children with developmental disabilities. The purpose of this study was to develop and evaluate an assessment for identifying the elementary' functions of vocal speech in children. Participants were 4 children with developmental disabilities, aged 6 years to 12 years, who exhibited at least one distinguishable vocal response (word or phrase) frequently in the natural environment. The assessment focused on three verbal operants delineated by Skinner (mand, tact, and intraverbal). One or more functions were identified for at least one vocal response of each child. Results suggested that this assessment would be useful for (a) evaluating Skinner's theory, (b) guiding decisions about language training for individual children, and (c) studying the nature of expressive language development in children with developmental disabilities.
C1 Louisiana State Univ, Baton Rouge, LA 70803 USA.
RP Lerman, DC (reprint author), Univ Houston, 2700 Bay Area Blvd,Campus Box 245, Houston, TX 77058 USA.
EM lerman@cl.uh.edu
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NR 28
TC 18
Z9 18
PU JOURNAL APPL BEHAV ANAL
PI LAWRENCE
PA DEPT HUMAN DEVELOPMENT, UNIV KANSAS, LAWRENCE, KS 66045 USA
SN 0021-8855
J9 J APPL BEHAV ANAL
JI J. Appl. Behav. Anal.
PD FAL
PY 2005
VL 38
IS 3
BP 303
EP 316
DI 10.1901/jaba.2005.106-04
PG 14
WC Psychology, Clinical
SC Psychology
GA 960OZ
UT WOS:000231604300002
PM 16270841
ER
PT J
AU Buckley, SD
Newchok, DK
AF Buckley, SD
Newchok, DK
TI An evaluation of simultaneous presentationand differential reinforcement
with response cost to reduce packing
SO JOURNAL OF APPLIED BEHAVIOR ANALYSIS
LA English
DT Article
DE packing; simultaneous presentation; food selectivity
ID FOOD REFUSAL; SELECTIVITY
AB We evaluated the effects of multiple treatment procedures, including simultaneous presentation of preferred foods, on the packing behavior of a 9-year-old girl with autism. A reversal design was used to assess the effects of differential reinforcement with response cost alone and with simultaneous presentation. In addition, simultaneous presentation was assessed independent of differential reinforcement with response cost. Results indicated that simultaneous presentation reduced packing and that differential reinforcement with response cost was not necessary to maintain these reductions. Results are discussed in terms of the use of simultaneous presentation for packing as an alternative to consequence manipulations.
C1 Allegro Sch, Cedar Knolls, NJ USA.
RP Buckley, SD (reprint author), 14 Willow Tce, Andover, NJ 07821 USA.
EM kegsbuckley@cs.com
CR Ahearn WH, 2003, J APPL BEHAV ANAL, V36, P361, DOI 10.1901/jaba.2003.36-361
Kahng S, 2001, J APPL BEHAV ANAL, V34, P93, DOI 10.1901/jaba.2001.34-93
Kern L, 1996, J APPL BEHAV ANAL, V29, P243, DOI 10.1901/jaba.1996.29-243
Patel MR, 2002, J APPL BEHAV ANAL, V35, P363, DOI 10.1901/jaba.2002.35-363
Piazza CC, 2002, J APPL BEHAV ANAL, V35, P259, DOI 10.1901/jaba.2002.35-259
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Sevin BM, 2002, J APPL BEHAV ANAL, V35, P65, DOI 10.1901/jaba.2002.35-65
NR 7
TC 8
Z9 8
PU JOURNAL APPL BEHAV ANAL
PI LAWRENCE
PA DEPT HUMAN DEVELOPMENT, UNIV KANSAS, LAWRENCE, KS 66045 USA
SN 0021-8855
J9 J APPL BEHAV ANAL
JI J. Appl. Behav. Anal.
PD FAL
PY 2005
VL 38
IS 3
BP 405
EP 409
DI 10.1901/jaba.2005.71-04
PG 5
WC Psychology, Clinical
SC Psychology
GA 960OZ
UT WOS:000231604300013
PM 16270850
ER
PT J
AU Kalyva, E
Avramidis, E
AF Kalyva, E
Avramidis, E
TI Improving communication between children with autism and their peers
through the 'circle of friends': A small-scale intervention study
SO JOURNAL OF APPLIED RESEARCH IN INTELLECTUAL DISABILITIES
LA English
DT Article
DE autism; circle of friends; peer group; social skills intervention
ID SOCIAL-SKILLS; STUDENTS; BEHAVIOR; PRESCHOOLERS; CLASSROOM; PLAY
AB Background The 'circle of friends' is an educational approach that facilitates the inclusion of children with disabilities into the school community by engaging their peer group in supporting the individual proactively. The present small-scale study examines the efficacy of this intervention in improving the communication (and ultimately social) skills of pre-school aged children with autism.
Methods Five children identified with autism aged between 3.10 and 4.7 years participated in the study - three in the intervention and two in the control group. The 'circle of friends' was applied for 30 min on a weekly basis at a nursery setting for a period of 3 months with the active involvement of one teacher and five peers of each child with autism. The effects of the intervention were systematically examined by means of an observation schedule which recorded the number of responses and initiation attempts - both unsuccessful and successful - of all participating children with autism during baseline, post-intervention and at 2 months follow-up.
Results The statistical analysis of the data revealed that children in the intervention group had significantly lower unsuccessful response and initiation rates at post-intervention and follow-up than children in the control group. Moreover, children in the intervention group had significantly higher successful response and initiation rates at post-intervention and follow-up than those in the control group.
Conclusions The recorded changes in the interaction patterns indicate that the 'circle of friends' is a powerful intervention that, if carefully applied, can improve the social skills of children with autism and their ability to communicate, and ultimately facilitate their 'inclusion' in mainstream settings. Further larger-scale longitudinal research is needed to examine the long-term benefits of the approach for children with autism and the broader changes in the nexus of relations within the mainstream environment.
C1 Univ Sheffield, City Liberal Studies, Thessaloniki 54622, Greece.
Univ York, Dept Educ Studies, York YO10 5DD, N Yorkshire, England.
RP Kalyva, E (reprint author), Univ Sheffield, City Liberal Studies, 24 Proxenou Koromila St, Thessaloniki 54622, Greece.
EM kalyva@city.academic.gr
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NR 42
TC 16
Z9 16
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 1360-2322
J9 J APPL RES INTELLECT
JI J. Appl. Res. Intellect. Disabil.
PD SEP
PY 2005
VL 18
IS 3
BP 253
EP 261
DI 10.1111/j.1468-3148.2005.00232.x
PG 9
WC Psychology, Educational; Rehabilitation
SC Psychology; Rehabilitation
GA 952GU
UT WOS:000230992800006
ER
PT J
AU Zoghbi, HY
AF Zoghbi, HY
TI MeCP2 dysfunction in humans and mice
SO JOURNAL OF CHILD NEUROLOGY
LA English
DT Article; Proceedings Paper
CT 33rd Annual Meeting of the Child-Neurology-Society
CY OCT 13-16, 2004
CL Toronto, CANADA
SP Child Neurol Soc
ID LINKED MENTAL-RETARDATION; X-CHROMOSOME INACTIVATION; CLASSIC
RETT-SYNDROME; MUTATION TYPE; TRANSCRIPTIONAL REPRESSOR; SOMATIC
MOSAICISM; MOUSE MODEL; HOT-SPOT; GENE; DISORDER
AB Rett syndrome is a leading cause of postnatal neurodevelopmental regression. Rett syndrome is caused by mutations in MECP2, the gene encoding methyl-CpG binding protein 2. In up to 96% of all classic cases, Rett syndrome cases are caused by mutations or deletions in MECP2. The phenotypic spectrum of MECP2 mutations is broad and includes mental retardation with or without seizures, Angelman syndrome-like phenotype, and autism. Mecp(308/Y) mice carry a truncating mutation and display many of the features seen in Rett syndrome. Social behavior abnormalities and impaired social interactions in Mecp(308/Y) mice suggest that MeCP2 plays a role in modulating the activity of genes and neurons important for social interactions. Mice that overexpress MeCP2 at twice the endogenous levels develop a progressive neurologic disorder, demonstrating that MeCP2 levels are tightly regulated and raising the possibility that duplications or gain-of-function mutations of MECP2 might underlie some cases of neurodevelopmental X-linked disorders.
C1 Baylor Coll Med, Houston, TX 77030 USA.
Howard Hughes Med Inst, Houston, TX 77030 USA.
RP Zoghbi, HY (reprint author), 1 Baylor Plaza,Room T807, Houston, TX 77030 USA.
EM hzoghbi@bcm.edu
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NR 50
TC 41
Z9 41
PU B C DECKER INC
PI HAMILTON
PA 20 HUGHSON ST SOUTH, PO BOX 620, L C D 1, HAMILTON, ONTARIO L8N 3K7,
CANADA
SN 0883-0738
J9 J CHILD NEUROL
JI J. Child Neurol.
PD SEP
PY 2005
VL 20
IS 9
BP 736
EP 740
DI 10.1177/08830738050200090701
PG 5
WC Clinical Neurology; Pediatrics
SC Neurosciences & Neurology; Pediatrics
GA 968UO
UT WOS:000232188200006
PM 16225828
ER
PT J
AU Nomura, Y
Segawa, M
AF Nomura, Y
Segawa, M
TI Natural history of Rett syndrome
SO JOURNAL OF CHILD NEUROLOGY
LA English
DT Article; Proceedings Paper
CT 33rd Annual Meeting of the Child-Neurology-Society
CY OCT 13-16, 2004
CL Toronto, CANADA
SP Child Neurol Soc
ID MUTATIONS; DISORDER; AUTISM; GIRLS; AGE
AB Rett syndrome is a unique neurodevelopmental disorder, with onset of hypotoma, autistic tendency, and abnormalities of fine finger movements and gross movements of the arms in early infancy. Clinical features include specific age-dependent symptoms. Studies of early and late signs correlated locomotive dysfunction to language disability and stereotypy to regression of higher cortical functions. Studies of sleep parameters revealed early hypofunction of brainstem aminergic neurons and late occurrence of hypofunction of dopaminergic neurons, followed by receptor supersensitivity. The syndrome's pathophysiology suggests that early hypofunction of aminergic neurons interferes with the development of higher neuronal systems. Particular symptoms surface at different ages throughout the natural course of Rett syndrome, with regressional and static periods.
C1 Segawa Neurol Clin Children, Tokyo, Japan.
RP Nomura, Y (reprint author), 2-8 Surugadai Kanda, Tokyo 1010062, Japan.
EM nomura-y@segawa-clinic.jp
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NR 38
TC 17
Z9 17
PU B C DECKER INC
PI HAMILTON
PA 20 HUGHSON ST SOUTH, PO BOX 620, L C D 1, HAMILTON, ONTARIO L8N 3K7,
CANADA
SN 0883-0738
J9 J CHILD NEUROL
JI J. Child Neurol.
PD SEP
PY 2005
VL 20
IS 9
BP 764
EP 768
DI 10.1177/08830738050200091201
PG 5
WC Clinical Neurology; Pediatrics
SC Neurosciences & Neurology; Pediatrics
GA 968UO
UT WOS:000232188200011
PM 16225833
ER
PT J
AU Lauritsen, MB
Pedersen, CB
Mortensen, PB
AF Lauritsen, MB
Pedersen, CB
Mortensen, PB
TI Effects of familial risk factors and place of birth on the risk of
autism: A nationwide register-based study
SO JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY
LA English
DT Article
DE autism; Asperger's syndrome; PDD; family history; risk factors; place of
birth; maternal age; paternal age; parental age; psychiatric disorders;
immigrants
ID PERVASIVE DEVELOPMENTAL DISORDER; INFANTILE-AUTISM; NEONATAL FACTORS;
PATERNAL AGE; OBSTETRIC COMPLICATIONS; PSYCHIATRIC-DISORDERS;
MUTATION-RATE; PARENTAL AGE; POPULATION; CHILDREN
AB Background: The etiology of autism is unknown. A strong genetic component has been detected but non-genetic factors may also be involved in the etiology. Methods: We used data from the Danish Psychiatric Central Register and the Danish Civil Registration System to study some risk factors of autism, including place of birth, parental place of birth, parental age, family history of psychiatric disorders, and paternal identity. Results: A total of 943,664 children younger than ten years were followed from 1994 to 2001; of those, 818 children developed autism. The highest risks of autism were found in siblings of children with autism, or Asperger's syndrome and other pervasive developmental disorders (PDDs), with relative risks of 22 and 13, respectively. The relative risk of autism in the child was about twice as high if the mother had been diagnosed with a psychiatric disorder. The risk of autism was associated with increasing degree of urbanisation of the child's place of birth and with increasing paternal, but not maternal, age. An increased relative risk of 1.4 was found if the mother was born outside Europe, and in children of parents who were born in different countries. Conclusions: The highest risk of autism was found in families with a history of autism, or Asperger's syndrome and other PDDs in siblings, supporting the commonly accepted knowledge that genetic factors are involved in the etiology of autism.
C1 Aarhus Univ Hosp, Hosp Psychiat, Ctr Basic Psychiat Res, DK-8240 Risskov, Denmark.
Univ Aarhus, Natl Ctr Register Based Res, DK-8000 Aarhus, Denmark.
RP Lauritsen, MB (reprint author), Aarhus Univ Hosp, Hosp Psychiat, Ctr Basic Psychiat Res, DK-8240 Risskov, Denmark.
EM mbl@psykiatri.aaa.dk
RI Pedersen, Carsten Bocker/B-8441-2013
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TC 134
Z9 138
PU BLACKWELL PUBLISHING
PI OXFORD
PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND
SN 0021-9630
J9 J CHILD PSYCHOL PSYC
JI J. Child Psychol. Psychiatry
PD SEP
PY 2005
VL 46
IS 9
BP 963
EP 971
DI 10.1111/j.1469-7610.2004.00391.x
PG 9
WC Psychology, Developmental; Psychiatry; Psychology
SC Psychology; Psychiatry
GA 955XG
UT WOS:000231262000006
PM 16108999
ER
PT J
AU Volkmar, FR
Le Couteur, A
AF Volkmar, FR
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SO JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY
LA English
DT Book Review
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RP Volkmar, FR (reprint author), Yale Univ, Ctr Child Study, New Haven, CT 06520 USA.
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Z9 2
PU BLACKWELL PUBLISHING
PI OXFORD
PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND
SN 0021-9630
J9 J CHILD PSYCHOL PSYC
JI J. Child Psychol. Psychiatry
PD SEP
PY 2005
VL 46
IS 9
BP 1020
EP 1021
DI 10.1111/j.1469-7610.2005.01554.x
PG 2
WC Psychology, Developmental; Psychiatry; Psychology
SC Psychology; Psychiatry
GA 955XG
UT WOS:000231262000011
ER
PT J
AU Wolff, S
AF Wolff, S
TI Autism and creativity. Is there a link between autism in men and
exceptional ability?
SO JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY
LA English
DT Book Review
CR Fitzgerald M., 2004, AUTISM CREATIVITY IS
NR 1
TC 2
Z9 2
PU BLACKWELL PUBLISHING
PI OXFORD
PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND
SN 0021-9630
J9 J CHILD PSYCHOL PSYC
JI J. Child Psychol. Psychiatry
PD SEP
PY 2005
VL 46
IS 9
BP 1023
EP 1024
DI 10.1111/j.1469-7610.2005.01555_4.x
PG 2
WC Psychology, Developmental; Psychiatry; Psychology
SC Psychology; Psychiatry
GA 955XG
UT WOS:000231262000015
ER
PT J
AU Ozonoff, S
Goodlin-Jones, BL
Solomon, M
AF Ozonoff, S
Goodlin-Jones, BL
Solomon, M
TI Evidence-based assessment of autism spectrum disorders in children and
adolescents
SO JOURNAL OF CLINICAL CHILD AND ADOLESCENT PSYCHOLOGY
LA English
DT Review
ID PERVASIVE DEVELOPMENTAL DISORDERS; HIGH-FUNCTIONING CHILDREN; DSM-III-R;
EARLY INTERVENTION PROGRAMS; CRITERION-RELATED VALIDITY; PDD BEHAVIOR
INVENTORY; RATING-SCALE; ASPERGER-SYNDROME; CHILDHOOD AUTISM;
ADAPTIVE-BEHAVIOR
AB This article reviews evidence-based criteria that can guide practitioners in the selection, use, and interpretation of assessment tools for autism spectrum disorders (ASD). As Mash and Hunsley (2005) discuss in this special section, evidence-based assessment tools not only demonstrate adequate psychometric qualities, but also have relevance to the delivery of services to individuals with the disorder (see also Hayes, Nelson, & Jarrett, 1987). Thus, we use what is known about the symptoms, etiologies, developmental course, and outcome of ASD to evaluate the utility of particular assessment strategies and instruments for diagnosis, treatment planning and monitoring, and evaluation of outcome. The article begins with a review of relevant research on ASD. Next we provide an overview of the assessment process and some important issues that must be considered. We then describe the components of a core (minimum) assessment battery, followed by additional domains that might be considered in a more comprehensive assessment. Domains covered include core autism symptomatology, intelligence, language, adaptive behavior neuropsychological functions, comorbid psychiatric illnesses, and contextual factors (e.g., parent well-being, family functioning, quality of life). We end with a discussion of how well the extant literature meets criteria for evidence-based assessments.
C1 UC Davis, Ctr Med, MIND Inst, Sacramento, CA 95817 USA.
RP Ozonoff, S (reprint author), UC Davis, Ctr Med, MIND Inst, 2825 50th St, Sacramento, CA 95817 USA.
EM sjozonoff@ucdavis.edu
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NR 181
TC 85
Z9 86
PU LAWRENCE ERLBAUM ASSOC INC
PI MAHWAH
PA 10 INDUSTRIAL AVE, MAHWAH, NJ 07430-2262 USA
SN 1537-4416
J9 J CLIN CHILD ADOLESC
JI J. Clin. Child Adolesc. Psychol.
PD SEP
PY 2005
VL 34
IS 3
BP 523
EP 540
DI 10.1207/s15374424jccp3403_8
PG 18
WC Psychology, Clinical; Psychology, Developmental
SC Psychology
GA 948GG
UT WOS:000230703500008
PM 16083393
ER
PT J
AU Shaw, P
Bramham, J
Lawrence, EJ
Morris, R
Baron-Cohen, S
David, AS
AF Shaw, P
Bramham, J
Lawrence, EJ
Morris, R
Baron-Cohen, S
David, AS
TI Differential effects of lesions of the amygdala and prefrontal cortex on
recognizing facial expressions of complex emotions
SO JOURNAL OF COGNITIVE NEUROSCIENCE
LA English
DT Article
ID HIGH-FUNCTIONING AUTISM; TEMPORAL-LOBE EPILEPSY; ASPERGER-SYNDROME;
CEREBRAL ASYMMETRY; MIND IMPAIRMENTS; DECISION-MAKING; NORMAL ADULTS;
DAMAGE; RECOGNITION; BRAIN
AB Humans can detect facial expressions of both simple, basic emotions and expressions reflecting more complex states of mind. The latter includes emotional expressions that regulate social interactions ("social expressions" such as looking hostile or friendly) and expressions that reflect the inner thought state of others ("cognitive expressions" such as looking pensive). To explore the neural substrate of this skill, we examined performance on a test of detection of such complex expressions in patients with lesions of the temporal lobe (n = 54) or frontal lobe (n = 31). Of the temporal group, 18 had unilateral focal lesions of the amygdala and of the frontal group, 14 patients had unilateral lesions of the ventromedial prefrontal cortex-two regions held to be pivotal in mediating social cognitive skills. Damage to either the left or right amygdala was associated with impairment in the recognition of both social and cognitive expressions, despite an intact ability to extract information relating to invariant physical attributes. Lesions to all of the right prefrontal cortex-not just the ventromedial portions-led to a specific deficit in recognizing complex social expressions with a negative valence. The deficit in the group with right prefrontal cortical damage may contribute to the disturbances in social behavior associated with such lesions. The results also suggest that the amygdala has a role in processing a wide range of emotional expressions.
C1 NIH, NIMH, Child Psychiat Branch, Bethesda, MD 20892 USA.
Inst Psychiat, London, England.
Univ Cambridge, Cambridge, England.
RP Shaw, P (reprint author), NIH, NIMH, Child Psychiat Branch, Bldg 10,Rm 3N202, Bethesda, MD 20892 USA.
EM shawp@mail.nih.gov
RI Shaw, Philip/A-1129-2008; David, Anthony/C-1315-2011; Frank,
David/E-8213-2012
OI David, Anthony/0000-0003-0967-774X;
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NR 43
TC 50
Z9 50
PU M I T PRESS
PI CAMBRIDGE
PA 238 MAIN STREET, STE 500, CAMBRIDGE, MA 02142-1046 USA
SN 0898-929X
J9 J COGNITIVE NEUROSCI
JI J. Cogn. Neurosci.
PD SEP
PY 2005
VL 17
IS 9
BP 1410
EP 1419
DI 10.1162/0898929054985491
PG 10
WC Neurosciences; Psychology, Experimental
SC Neurosciences & Neurology; Psychology
GA 962TR
UT WOS:000231756000007
PM 16197694
ER
PT J
AU Cummings, AR
Carr, JE
AF Cummings, AR
Carr, JE
TI Functional analysis and treatment of joint dislocation associated with
hypermobility syndrome: A single-case analysis
SO JOURNAL OF DEVELOPMENTAL AND PHYSICAL DISABILITIES
LA English
DT Article
DE autism; curricular revision; differential reinforcement; extinction;
functional analysis; functional communication training; hypermobility
syndrome; noncontingent reinforcement
ID SELF-INJURIOUS-BEHAVIOR; DIAGNOSIS; CHILDREN
AB An experimental functional analysis indicated that the joint dislocation of a child diagnosed with autism was maintained by escape from instructional demands and possibly automatic reinforcement. A variety of behavioral treatments was subsequently evaluated, resulting in a treatment package that was successful in eliminating the behavior. The results are discussed in the context of conceptualizing and treating problem behaviors associated with physiological conditions.
C1 Cent E Preschool Autism Serv, Kinark Child & Family Serv, Markham, ON L3R 0E7, Canada.
Western Michigan Univ, Kalamazoo, MI 49008 USA.
RP Cummings, AR (reprint author), Cent E Preschool Autism Serv, Kinark Child & Family Serv, 600 Alden Rd, Markham, ON L3R 0E7, Canada.
EM anne.cummings@kinark.on.ca
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WORDSWORTH P, 1987, BRIT J RHEUMATOL, V26, P9
NR 20
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1056-263X
J9 J DEV PHYS DISABIL
JI J. Dev. Phys. Disabil.
PD SEP
PY 2005
VL 17
IS 3
BP 225
EP 236
DI 10.1007/s10882-005-4379-7
PG 12
WC Rehabilitation
SC Rehabilitation
GA 960NX
UT WOS:000231601500002
ER
PT J
AU Campbell, JM
Ferguson, JE
Herzinger, CV
Jackson, JN
Marino, C
AF Campbell, JM
Ferguson, JE
Herzinger, CV
Jackson, JN
Marino, C
TI Peers' attitudes toward autism differ across sociometric groups: An
exploratory investigation
SO JOURNAL OF DEVELOPMENTAL AND PHYSICAL DISABILITIES
LA English
DT Article
DE attitudes; autism; behavioral intentions; inclusion; sociometric status
ID SOCIAL-BEHAVIOR; CHILDRENS ATTITUDES; PERCEPTIONS; ACCEPTANCE; INTERACT;
BELIEFS
AB We examined the influence of sociometric status and the interactive effects of sociometric status and causal information on peers' initial impressions of an unfamiliar child with autism. Children (N = 576) enrolled in regular education completed sociometric nominations and responded to videotapes of a child portraying autistic behavior. In contrast to sociometrically average and rejected children, neglected children reported more negative attitudes toward the child with autism and less willingness to engage in academic activities with him. Popular children did not differ from other sociometric groups on self-reported attitudes and behavioral intentions toward the child with autism. We predicted that popular children would be the most responsive to causal information about autism; however, rejected children reported more willingness to engage in activities with the child with autism in the presence of explanatory information when compared to other sociometric groups.
C1 Univ Georgia, Dept Educ Psychol, Athens, GA 30602 USA.
Univ Georgia, Dept Educ Psychol, Athens, GA 30602 USA.
RP Campbell, JM (reprint author), Univ Georgia, Dept Educ Psychol, 325 Aderhold Hall, Athens, GA 30602 USA.
EM jcampbel@coe.uga.edu
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NR 28
TC 8
Z9 8
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1056-263X
J9 J DEV PHYS DISABIL
JI J. Dev. Phys. Disabil.
PD SEP
PY 2005
VL 17
IS 3
BP 281
EP 298
DI 10.1007/s10882-005-4386-8
PG 18
WC Rehabilitation
SC Rehabilitation
GA 960NX
UT WOS:000231601500006
ER
PT J
AU Williams, KE
Gibbons, BG
Schreck, KA
AF Williams, KE
Gibbons, BG
Schreck, KA
TI Comparing selective eaters with and without developmental disabilities
SO JOURNAL OF DEVELOPMENTAL AND PHYSICAL DISABILITIES
LA English
DT Article
DE selective eating; food selectivity; picky eating; feeding problems
ID FEEDING PROBLEMS; CHILDHOOD; DISORDERS
AB Food selectivity has been a problem identified in children with and without disabilities. This study examined 178 children referred to a feeding program for the evaluation and treatment of food selectivity. This sample was divided into three groups; children with autism spectrum disorders, children with special needs without autism, and children without special needs. Children with autism spectrum disorders insisted on using the same utensil or dish and insisted on having food prepared in a certain way significantly more often than other children. Children with special needs had significantly more problems with spitting out food as well as oral motor delays than other children. Children without special needs had significantly more problems with anxiety or obsessive-compulsive behaviors than other children. Most caregivers reported their child's feeding problems started prior to 18 months of age and persisted longer than 24 months, which is inconsistent with the hypothesis that food selectivity, at least for some children, is not a transient phase.
C1 Penn State Univ, Hershey Med Ctr, Feeding Program H085, Hershey, PA 19033 USA.
Penn State Harrisburg, Middletown, CT USA.
RP Williams, KE (reprint author), Penn State Univ, Hershey Med Ctr, Feeding Program H085, Hershey, PA 19033 USA.
EM feedingprogram@hmc.psu.edu
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NR 18
TC 28
Z9 28
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1056-263X
J9 J DEV PHYS DISABIL
JI J. Dev. Phys. Disabil.
PD SEP
PY 2005
VL 17
IS 3
BP 299
EP 309
DI 10.1007/s10882-005-4387-7
PG 11
WC Rehabilitation
SC Rehabilitation
GA 960NX
UT WOS:000231601500007
ER
PT J
AU Yoder, P
Camarata, S
Gardner, E
AF Yoder, P
Camarata, S
Gardner, E
TI Treatment effects on speech intelligibility and length of utterance in
children with specific language and intelligibility impairments
SO JOURNAL OF EARLY INTERVENTION
LA English
DT Article
ID PRELINGUISTIC COMMUNICATION; INTENTIONAL COMMUNICATION; PHONOLOGICAL
DISORDERS; INTERVENTION; DISABILITIES; AUTISM; DELAYS
AB This purpose of this randomized group experiment was (a) to test the post-treatment (i.e., immediately after treatment) and follow-up (i.e., 8 months after the end of treatment) efficacy of a treatment designed to facilitate both sentence length and speech intelligibility (i.e., broad target recast), and (b) to explore whether pretreatment speech accuracy predicted response to treatment in children with severe phonological and expressive language impairment. The results support the conclusion that broad target recast facilitated follow-up speech intelligibility in children whose speech accuracy was relatively low prior to treatment.
C1 Vanderbilt Univ, Nashville, TN 37203 USA.
RP Yoder, P (reprint author), Vanderbilt Univ, Peabody Box 328, Nashville, TN 37203 USA.
EM paul.yoder@vanderbilt.edu
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Tabachnick B.G., 1996, USING MULTIVARIATE S, V2nd
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YODER P, 2005, UNPUB PREDICTORS LAT
YODER P, 2004, UNPUB FAMILIARITY EF
Yoder PJ, 2001, J SPEECH LANG HEAR R, V44, P224, DOI 10.1044/1092-4388(2001/019)
Yoder PJ, 1998, J SPEECH LANG HEAR R, V41, P1207
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NR 43
TC 5
Z9 5
PU COUNCIL EXCEPTIONAL CHILDREN
PI ARLINGTON
PA 1110 N GLEBE RD, ARLINGTON, VA 22201-5704 USA
SN 1053-8151
J9 J EARLY INTERVENTION
JI J. Early Interv.
PD FAL
PY 2005
VL 28
IS 1
BP 34
EP 49
DI 10.1177/105381510502800105
PG 16
WC Education, Special; Psychology, Educational; Rehabilitation
SC Education & Educational Research; Psychology; Rehabilitation
GA 986HP
UT WOS:000233441000005
ER
PT J
AU Holmes, E
Willoughby, T
AF Holmes, E
Willoughby, T
TI Play behaviour of children with autism spectrum disorders
SO JOURNAL OF INTELLECTUAL & DEVELOPMENTAL DISABILITY
LA English
DT Article
ID PRESCHOOL-CHILDREN
AB Background We investigated the play behaviours of children with autism. Cognitive and social levels of play engaged in by 4 to 8-year-old children with autism spectrum disorders were examined in naturalistic classroom settings. In addition, play at home was compared with play at school via mother and educator questionnaires.
Method Seventeen school-aged children, their educators, and their mothers participated in the study. Each participant was observed for one free play session on 5 separate days.
Results The most frequently observed play behaviours included parallel-functional play, adult interactions, and solitary-functional play. Mothers and educators did not differ significantly in their perspectives of the participants' play behaviours. In general, educators' and mothers' reports were positively related to researcher observations of participants' play behaviours.
Conclusions This study provides baseline data for future research on the play behaviours of children with autism spectrum disorders. Methodological considerations and practical implications of the findings are discussed.
C1 SUNY Buffalo, Dept Counseling & Educ Psychol, Buffalo, NY 14260 USA.
Brock Univ, St Catharines, ON L2S 3A1, Canada.
RP Holmes, E (reprint author), SUNY Buffalo, Dept Counseling & Educ Psychol, Buffalo, NY 14260 USA.
EM lizholmes@canada.com
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NR 24
TC 11
Z9 11
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 1366-8250
J9 J INTELLECT DEV DIS
JI J. Intellect. Dev. Dis.
PD SEP
PY 2005
VL 30
IS 3
BP 156
EP 164
DI 10.1080/13668250500204034
PG 9
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA 975HG
UT WOS:000232651000004
ER
PT J
AU Roberts, JE
Symons, FJ
Johnson, AM
Hatton, DD
Boccia, ML
AF Roberts, JE
Symons, FJ
Johnson, AM
Hatton, DD
Boccia, ML
TI Blink rate in boys with fragile X syndrome: preliminary evidence for
altered dopamine function
SO JOURNAL OF INTELLECTUAL DISABILITY RESEARCH
LA English
DT Article
DE arousal; blink rate; development disabilities; dopamine; fragile X;
modulation
ID DEFICIT-HYPERACTIVITY DISORDER; EYE-BLINK; STEREOTYPED BEHAVIOR;
MENTAL-RETARDATION; YOUNG-CHILDREN; AUTISM; ATTENTION; MALES; PHENOTYPE;
SCHIZOPHRENIA
AB Background Dopamine, a neurotransmitter involved in motor and cognitive functioning, can be non-invasively measured via observation of spontaneous blink rates. Blink rates have been studied in a number of clinical conditions including schizophrenia, autism, Parkinsons, and attention deficit/hyperactivity disorder with results implicating either hyper or hypo dopaminergic states.
Methods This study examined spontaneous blink rate in boys with fragile X syndrome (FXS). Blink rates of boys (4-8 years old) with FXS (n = 6) were compared with those of age-matched typically developing boys (n = 6) during active and passive tasks. Blink rates (blinks per minute) for each task were compared between the two groups. Then, the relation between blink measures and core FXS-related features [problem behaviours, arousal, fmr 1 protein (FMRP)] were examined within the group of boys with FXS.
Results Blink rate in boys with FXS was significantly higher than typically developing boys during passive tasks. Within the FXS group, there were significant correlations between blink rate and problem behaviours and physiological arousal (i.e. heart activity) but not with FMRP.
Conclusions Observed differences in spontaneous blink rate between boys with and without FXS and the relation between blink rate and physiological and behavioural measures in boys with FXS suggests that further work examining dopamine dysfunction as a factor in the pathophysiology of FXS may be warranted.
C1 Univ N Carolina, Frank Porter Graham Child Dev Inst, Chapel Hill, NC 27599 USA.
Univ Minnesota, Dept Educ Psychol, Minneapolis, MN 55455 USA.
RP Roberts, JE (reprint author), Univ N Carolina, Frank Porter Graham Child Dev Inst, CB 8040, Chapel Hill, NC 27599 USA.
EM roberts2@mail.fpg.unc.edu
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NR 67
TC 12
Z9 12
PU BLACKWELL PUBLISHING
PI OXFORD
PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND
SN 0964-2633
J9 J INTELL DISABIL RES
JI J. Intell. Disabil. Res.
PD SEP
PY 2005
VL 49
BP 647
EP 656
DI 10.1111/j.1365-2788.2005.00713.x
PN 9
PG 10
WC Education, Special; Genetics & Heredity; Clinical Neurology; Psychiatry;
Rehabilitation
SC Education & Educational Research; Genetics & Heredity; Neurosciences &
Neurology; Psychiatry; Rehabilitation
GA 955XF
UT WOS:000231261900002
PM 16108982
ER
PT J
AU Eisenhower, AS
Baker, BL
Blacher, J
AF Eisenhower, AS
Baker, BL
Blacher, J
TI Preschool children with intellectual disability: syndrome specificity,
behaviour problems, and maternal well-being
SO JOURNAL OF INTELLECTUAL DISABILITY RESEARCH
LA English
DT Article
DE autism; behavioural phenotypes; cerebral palsy; Down syndrome;
intellectual disability; syndrome specificity
ID MENTAL-RETARDATION; DOWN-SYNDROME; PARENTING STRESS;
DEVELOPMENTAL-DISABILITIES; MALADAPTIVE BEHAVIOR; AUTISTIC-CHILDREN;
ADAPTIVE-BEHAVIOR; POSITIVE IMPACT; AGE-CHILDREN; YOUNG-ADULTS
AB Background Children with intellectual disability (ID) are at heightened risk for behaviour problems and diagnosed mental disorder. Likewise, mothers of children with ID are more stressed than mothers of typically developing children. Research on behavioural phenotypes suggests that different syndromes of ID may be associated with distinct child behavioural risks and maternal well-being risks. In the present study, maternal reports of child behaviour problems and maternal well-being were examined for syndrome-specific differences.
Methods The present authors studied the early manifestation and continuity of syndrome-specific behaviour problems in 215 preschool children belonging to 5 groups (typically developing, undifferentiated developmental delays, Down syndrome, autism, cerebral palsy) as well as the relation of syndrome group to maternal well-being.
Results At age 3, children with autism and cerebral palsy showed the highest levels of behaviour problems, and children with Down syndrome and typically developing children showed the lowest levels. Mothers of children with autism reported more parenting stress than all other groups. These syndrome-specific patterns of behaviour and maternal stress were stable across ages 3, 4 and 5 years, except for relative increases in behaviour problems and maternal stress in the Down syndrome and cerebral palsy groups. Child syndrome contributed to maternal stress even after accounting for differences in behaviour problems and cognitive level.
Conclusions These results, although based on small syndrome groups, suggest that phenotypic expressions of behaviour problems are manifested as early as age 3. These behavioural differences were paralleled by differences in maternal stress, such that mothers of children with autism are at elevated risk for high stress. In addition, there appear to be other unexamined characteristics of these syndromes, beyond behaviour problems, which also contribute to maternal stress.
C1 Univ Calif Los Angeles, Dept Psychol, Los Angeles, CA 90095 USA.
Univ Calif Riverside, Grad Sch Educ, Riverside, CA 92521 USA.
RP Eisenhower, AS (reprint author), Univ Calif Los Angeles, Dept Psychol, 405 Hilgard Ave, Los Angeles, CA 90095 USA.
EM aeisenho@ucla.edu
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NR 50
TC 153
Z9 153
PU BLACKWELL PUBLISHING
PI OXFORD
PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND
SN 0964-2633
J9 J INTELL DISABIL RES
JI J. Intell. Disabil. Res.
PD SEP
PY 2005
VL 49
BP 657
EP 671
DI 10.1111/j.1365-2788.2005.00699.x
PN 9
PG 15
WC Education, Special; Genetics & Heredity; Clinical Neurology; Psychiatry;
Rehabilitation
SC Education & Educational Research; Genetics & Heredity; Neurosciences &
Neurology; Psychiatry; Rehabilitation
GA 955XF
UT WOS:000231261900003
PM 16108983
ER
PT J
AU de Bildt, A
Sytema, S
Kraijer, D
Sparrow, S
Minderaa, R
AF de Bildt, A
Sytema, S
Kraijer, D
Sparrow, S
Minderaa, R
TI Adaptive functioning and behaviour problems in relation to level of
education in children and adolescents with intellectual disability
SO JOURNAL OF INTELLECTUAL DISABILITY RESEARCH
LA English
DT Article
DE adaptive functioning; autism; behaviour problems; education;
intellectual disability
ID PERVASIVE DEVELOPMENTAL DISORDERS; DOWN-SYNDROME; FRAGILE-X; AUTISM;
SCALES; MALES
AB Background The interrelationship between adaptive functioning, behaviour problems and level of special education was studied in 186 children with IQs ranging from 61 to 70. The objective was to increase the insight into the contribution of adaptive functioning and general and autistic behaviour problems to the level of education in children with intellectual disability (ID).
Methods Children from two levels of special education in the Netherlands were compared with respect to adaptive functioning [Vineland Adaptive Behavior Scales (VABS)], general behaviour problems [Child Behavior Checklist (CBCL)] and autistic behaviour problems [Autism Behavior Checklist (ABC)]. The effect of behaviour problems on adaptive functioning, and the causal relationships between behaviour problems, adaptive functioning and level of education were investigated.
Results Children in schools for mild learning problems had higher VABS scores, and lower CBCL and ABC scores. The ABC had a significant effect on the total age equivalent of the VABS in schools for severe learning problems, the CBCL in schools for mild learning problems. A direct effect of the ABC and CBCL total scores on the VABS age equivalent was found, together with a direct effect of the VABS age equivalent on level of education and therefore an indirect effect of ABC and CBCL on level of education.
Conclusions In the children with the highest level of mild ID, adaptive functioning seems to be the most important factor that directly influences the level of education that a child attends. Autistic and general behaviour problems directly influence the level of adaptive functioning. Especially, autistic problems seem to have such a restrictive effect on the level of adaptive functioning that children do not reach the level of education that would be expected based on IQ. Clinical implications are discussed.
C1 Univ Groningen, Ctr Child & Adolescent Psychiat, NL-9700 AR Groningen, Netherlands.
St Hendrik Boeijen, Assen, Netherlands.
Yale Univ, Ctr Child Study, New Haven, CT 06520 USA.
RP de Bildt, A (reprint author), Univ Groningen, Ctr Child & Adolescent Psychiat, POB 660, NL-9700 AR Groningen, Netherlands.
EM a.de.bildt@accare.nl
RI Sytema, Sjoerd/B-2058-2010
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NR 44
TC 22
Z9 22
PU BLACKWELL PUBLISHING
PI OXFORD
PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND
SN 0964-2633
J9 J INTELL DISABIL RES
JI J. Intell. Disabil. Res.
PD SEP
PY 2005
VL 49
BP 672
EP 681
DI 10.1111/j.1365-2788.2005.00711.x
PN 9
PG 10
WC Education, Special; Genetics & Heredity; Clinical Neurology; Psychiatry;
Rehabilitation
SC Education & Educational Research; Genetics & Heredity; Neurosciences &
Neurology; Psychiatry; Rehabilitation
GA 955XF
UT WOS:000231261900004
PM 16108984
ER
PT J
AU Frohna, JG
AF Frohna, JG
TI Toward better evidence for parent training programs for autism spectrum
disorder
SO JOURNAL OF PEDIATRICS
LA English
DT Editorial Material
C1 Univ Michigan, Dept Pediat, Ann Arbor, MI 48109 USA.
Univ Michigan, Dept Internal Med, Ann Arbor, MI 48109 USA.
Univ Michigan, Dept Med Educ, Ann Arbor, MI 48109 USA.
RP Frohna, JG (reprint author), Univ Michigan, Dept Pediat, 3116 Taubman,Box 0368, Ann Arbor, MI 48109 USA.
CR Bryson SE, 2003, CAN J PSYCHIAT, V48, P506
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NR 7
TC 1
Z9 1
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0022-3476
EI 1097-6833
J9 J PEDIATR-US
JI J. Pediatr.
PD SEP
PY 2005
VL 147
IS 3
BP 283
EP 284
DI 10.1016/j.peds.2005.05.036
PG 2
WC Pediatrics
SC Pediatrics
GA 971VE
UT WOS:000232412100004
PM 16182660
ER
PT J
AU McConachie, H
Randle, V
Hammal, D
Le Couteur, A
AF McConachie, H
Randle, V
Hammal, D
Le Couteur, A
TI A controlled trial of a training course for parents of children with
suspected autism spectrum disorder
SO JOURNAL OF PEDIATRICS
LA English
DT Article
ID PERVASIVE DEVELOPMENTAL DISORDERS; JOINT ATTENTION; 3-YEAR-OLD CHILDREN;
EARLY INTERVENTION; QUESTIONNAIRE; DIAGNOSIS; DEFICITS; STRESS
AB Objective To evaluate a training course for parents, designed to help them understand autism spectrum disorder and to facilitate social communication with their young child.
Study design Controlled trial for 51 children aged 24 to 48 months, whose parents received either immediate intervention or delayed access to the course. Outcome was measured 7 months after recruitment in parents' use of facilitative strategies, stress, adaptation to the child; and in children's vocabulary size, behavior problems, and social communication skills.
Results Taking into account scores at recruitment, child's level of ability, diagnostic grouping, and the interval between assessments, a significant advantage was found for the intervention group in parents' observed use,of facilitative strategies and in children's vocabulary size.
Conclusions The training course is well received by parents and has a measurable effect on both parents' and children's communication skills.
C1 Univ Newcastle Upon Tyne, Royal Victoria Infirm, Sir James Spence Inst, Sch Clin Med Sci, Newcastle Upon Tyne NE1 4LP, Tyne & Wear, England.
RP McConachie, H (reprint author), Univ Newcastle Upon Tyne, Royal Victoria Infirm, Sir James Spence Inst, Sch Clin Med Sci, Newcastle Upon Tyne NE1 4LP, Tyne & Wear, England.
EM h.r.mcconachie@newcastle.ac.uk
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NR 33
TC 50
Z9 52
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0022-3476
EI 1097-6833
J9 J PEDIATR-US
JI J. Pediatr.
PD SEP
PY 2005
VL 147
IS 3
BP 335
EP 340
DI 10.1016/j.jpeds.2005.03.056
PG 6
WC Pediatrics
SC Pediatrics
GA 971VE
UT WOS:000232412100016
PM 16182672
ER
PT J
AU Koegel, LK
Koegel, RL
Nefdt, N
Fredeen, R
Klein, EF
Bruinsma, YEM
AF Koegel, LK
Koegel, RL
Nefdt, N
Fredeen, R
Klein, EF
Bruinsma, YEM
TI First STEP - A Model for the early identification of children with
autism spectrum disorders
SO JOURNAL OF POSITIVE BEHAVIOR INTERVENTIONS
LA English
DT Editorial Material
ID YOUNG-CHILDREN; TODDLERS
C1 Univ Calif Santa Barbara, Grad Sch Educ, Autism Res & Training Ctr, Santa Barbara, CA 93106 USA.
Univ Calif Santa Barbara, Gevirtz Grad Sch Educ, Counseling Clin Sch Psychol Program, Santa Barbara, CA 93106 USA.
Autism Ctr Oegstgeest, Oegstgeest, Netherlands.
RP Koegel, LK (reprint author), Univ Calif Santa Barbara, Grad Sch Educ, Autism Res & Training Ctr, Santa Barbara, CA 93106 USA.
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
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NR 21
TC 5
Z9 5
PU PRO-ED INC
PI AUSTIN
PA 8700 SHOAL CREEK BLVD, AUSTIN, TX 78757-6897 USA
SN 1098-3007
J9 J POSIT BEHAV INTERV
JI J. Posit. Behav. Interv.
PD FAL
PY 2005
VL 7
IS 4
BP 247
EP 252
DI 10.1177/10983007050070040601
PG 6
WC Psychology, Clinical; Education, Special
SC Psychology; Education & Educational Research
GA 977FM
UT WOS:000232788100006
ER
PT J
AU Dinca, O
Paul, M
Spencer, NJ
AF Dinca, O
Paul, M
Spencer, NJ
TI Systematic review of randomized controlled trials of atypical
antipsychotics and selective serotonin reuptake inhibitors for
behavioural problems associated with pervasive developmental disorders
SO JOURNAL OF PSYCHOPHARMACOLOGY
LA English
DT Review
DE systematic review; pervasive developmental disorder; autism atypical
antipsychotics; selective serotonin reuptake inhibitors; behavioural
problems
ID AUTISTIC SPECTRUM DISORDERS; SELF-INJURIOUS-BEHAVIOR; OPEN-LABEL;
MENTAL-RETARDATION; DOUBLE-BLIND; RISPERIDONE TREATMENT; YOUNG-CHILDREN;
CASE SERIES; FLUVOXAMINE TREATMENT; FLUOXETINE TREATMENT
AB A systematic review of randomized controlled trials of the use of atypical antipsychotics and selective serotonin reuptake inhibitors in the treatment of behavioural problems associated with pervasive developmental disorders is reported. A search through both published and unpublished literature, including contacting drug companies and known experts in the field was undertaken. Six trials met the criteria for inclusion in the review. They largely suffer from methodological weaknesses; only two trials had satisfactory methodological quality. The heterogeneity in outcome measurements prevented from conducting a meta-analysis. There is yet no coherent body of data concerning the effects of these medications across all sub-classifications of pervasive developmental disorders, across all age categories, and concerning their medium- and long-term effects, and their effects on quality of life. Atypical antipsychotics and selective serotonin reuptake inhibitors may be of benefit for behavioural problems associated with pervasive developmental disorders. Risperidone has been the best studied among these medications. Atypical antipsychotics appear to have a low risk of extrapyramidal symptoms during short-term treatment. The reviewed trials cannot provide data on the use of selective serotonin reuptake inhibitors in the treatment of children with pervasive developmental disorders. No firm conclusions for clinical practice can be drawn. Larger, well-conducted randomized controlled trials with tong-term follow-up are needed.
C1 Univ Warwick, Sch Postgrad Med Educ, Coventry CV4 7AL, W Midlands, England.
Univ Warwick, Sch Med, Coventry CV4 7AL, W Midlands, England.
RP Dinca, O (reprint author), Univ Warwick, Sch Postgrad Med Educ, Avon Bldg,Westwood Site,Gibbet Hill Rd, Coventry CV4 7AL, W Midlands, England.
EM oanadinca9@yahoo.com
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NR 108
TC 11
Z9 11
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0269-8811
J9 J PSYCHOPHARMACOL
JI J. Psychopharmacol.
PD SEP
PY 2005
VL 19
IS 5
BP 521
EP 532
DI 10.1177/0269881105056541
PG 12
WC Clinical Neurology; Neurosciences; Pharmacology & Pharmacy; Psychiatry
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA 965LL
UT WOS:000231951900012
PM 16166190
ER
PT J
AU [Anonymous]
AF [Anonymous]
TI A mercurial debate over autism
SO NATURE NEUROSCIENCE
LA English
DT Editorial Material
CR Bernard S, 2001, MED HYPOTHESES, V56, P462, DOI 10.1054/mehy.2000.1281
Geschwind DH, 2001, AM J HUM GENET, V69, P463, DOI 10.1086/321292
KENNEDY RF, 2005, ROLLING STONE 0620
2004, IMMUNIZATION SAFETY
NR 4
TC 0
Z9 0
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 1097-6256
EI 1546-1726
J9 NAT NEUROSCI
JI Nat. Neurosci.
PD SEP
PY 2005
VL 8
IS 9
BP 1123
EP 1123
DI 10.1038/nn0905-1123
PG 1
WC Neurosciences
SC Neurosciences & Neurology
GA 958YJ
UT WOS:000231483800001
ER
PT J
AU Moller, AR
Kern, JK
Grannemann, B
AF Moller, AR
Kern, JK
Grannemann, B
TI Are the non-classical auditory pathways involved in autism and PDD?
SO NEUROLOGICAL RESEARCH
LA English
DT Article
DE austism; auditory pathways; PDD
ID CUTANEOUS-EVOKED TINNITUS; MEDIAL GENICULATE-BODY; INFERIOR COLLICULUS;
GUINEA-PIG; SOMATOSENSORY SYSTEMS; COCHLEAR NUCLEI; CAT; PAIN;
INTEGRATION; MECHANISMS
AB Objective: To test the hypothesis that some of the abnormal sensory perceptions that characterize autism may be explained by an abnormal activation of non-classical (extra-lemniscal) sensory pathways.
Methods: Twenty-one individuals, 18-45 years of age who were diagnosed with autism participated in the study. Sounds (clicks presented at a rate of 40 per second and 65 dB above the normal threshold) were applied through earphones. Electrical stimulation (100 mu S rectangular impulses at a rate of 4 per second) was applied through electrodes placed on the skin over the median nerve at the wrist. The participants were asked to match the loudness of the sound with and without the electrical stimulation applied to the median nerve.
Results: Electrical stimulation of the median nerve at the wrist in individuals with autism could change the perception of loudness of sounds presented to one ear through an earphone showing a statistically significant abnormal sensory cross-modal interaction.
Discussion: We interpreted our results to support the hypothesis that some individuals with autism have an abnormal cross-modal interaction between the auditory and the somatosensory systems. Cross-modal interaction between senses such as hearing and the somatosensory system does not occur normally in adults. As only the non-classical (extralemniscal) ascending auditory pathways receive somatosensory input, the presence of cross-modal interaction in autistic individuals is a sign that autism is associated with abnormal involvement of the non-classical auditory pathways, implying that sensory information is processed by different populations of neurons than in non-autistic individuals.
C1 Univ Texas, Sch Behav & Brain Sci, Richardson, TX 75083 USA.
Univ Texas, SW Med Ctr, Dept Psychiat, Dallas, TX USA.
RP Moller, AR (reprint author), Univ Texas, Sch Behav & Brain Sci, GR 41,POB 830688, Richardson, TX 75083 USA.
EM amoller@utdallas.edu
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NR 45
TC 20
Z9 20
PU MANEY PUBLISHING
PI LEEDS
PA HUDSON RD, LEEDS LS9 7DL, ENGLAND
SN 0161-6412
J9 NEUROL RES
JI Neurol. Res.
PD SEP
PY 2005
VL 27
IS 6
BP 625
EP 629
DI 10.1179/016164105X25117
PG 5
WC Clinical Neurology; Neurosciences
SC Neurosciences & Neurology
GA 965ND
UT WOS:000231956300009
PM 16157013
ER
PT J
AU Marui, T
Koishi, S
Funatogawa, I
Yamamoto, K
Matsumoto, H
Hashimoto, O
Nanba, E
Kato, C
Ishijima, M
Watanabe, K
Kasai, K
Kato, N
Sasaki, T
AF Marui, T
Koishi, S
Funatogawa, I
Yamamoto, K
Matsumoto, H
Hashimoto, O
Nanba, E
Kato, C
Ishijima, M
Watanabe, K
Kasai, K
Kato, N
Sasaki, T
TI No association of FOXP2 and PTPRZ1 on 7q31 with autism from the Japanese
population
SO NEUROSCIENCE RESEARCH
LA English
DT Article
DE autism; chromosome 7q; FOXP2; PTPRZ1; genetic association
ID SUSCEPTIBILITY GENE; LANGUAGE; DISORDER; SPEECH
AB Autism is a child-onset pervasive developmental disorder, with a significant role of genetic factors in its development. Genome-wide linkage studies have suggested a 7q region as a susceptibility locus for autism. We investigated several single nucleotide polymorphisms (SNPs) of Forkhead Box P2 (FOXP2) and Protein-Tyrosine Phosphatase, Receptor-type, Zeta-1 (PTPRZ1) at the 7q region in Japanese patients with autism and healthy controls. No significant difference was observed, after correction for the multiple testing, in allele, genotype or haplotype frequencies of the SNPs of FOXP2 or PTPRZ1 between patients and controls. No evidence was thus obtained for a major role of FOXP2 or PTPRZ1 in the development of autism. (c) 2005 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.
C1 Univ Tokyo, Grad Sch Med, Dept Neuropsychiat, Tokyo, Japan.
Tokai Univ, Sch Med, Dept Psychiat, Isehara, Kanagawa 25911, Japan.
Univ Tokyo, Sch Hlth Sci & Nursing, Dept Biostat, Tokyo, Japan.
Nagoya Univ, Grad Sch Med, Dept Psychiat, Nagoya, Aichi, Japan.
Tottori Univ, Gene Res Ctr, Yonago, Tottori 683, Japan.
Univ Tokyo, Hlth Serv Ctr, Dept Psychiat, Tokyo 113, Japan.
RP Sasaki, T (reprint author), Univ Tokyo, Grad Sch Med, Dept Neuropsychiat, Tokyo, Japan.
EM psytokyo@yahoo.ac.jp
CR BONORA E, 2004, EUR J HUM GENET
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NR 13
TC 16
Z9 17
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
IRELAND
SN 0168-0102
J9 NEUROSCI RES
JI Neurosci. Res.
PD SEP
PY 2005
VL 53
IS 1
BP 91
EP 94
DI 10.1016/j.neures.2005.05.003
PG 4
WC Neurosciences
SC Neurosciences & Neurology
GA 957BK
UT WOS:000231344100012
PM 15998549
ER
PT J
AU Anckarsater, HS
AF Anckarsater, HS
TI Clinical neuropsychiatric symptoms in perpetrators of severe crimes
against persons
SO NORDIC JOURNAL OF PSYCHIATRY
LA English
DT Article
DE ADHD; aggression; autism; psychopathy
ID WEAK CENTRAL COHERENCE; ASPERGER-SYNDROME; COGNITIVE PHENOTYPE;
PSYCHOPATHY; AUTISM; DISORDER; CHILDREN; CHILDHOOD; EPIDEMIOLOGY;
INDIVIDUALS
AB The objective of the study was to explore the possibility of common signs and symptoms of childhood-onset neuropsychiatric disorders and personality disorders, especially psychopathy, in a cohort of violent offenders. A structured neuropsychiatric status comprising features recorded in childhood-onset neuropsychiatric disorders and adult personality disorders was assessed in 89 perpetrators of severe crimes against other persons, analysed for factor structure, and compared to clinical diagnostics of neuropsychiatric disorders and independent assessments of psychopathy rated by the Psychopathy Checklist Revised (PCL- R). One or several childhood-onset neuropsychiatric disorders [ autism, attention-deficit/hyperactivity disorder (AD/ HD), tics and learning disability] affected the majority of adult offenders. A factor analysis yielded four higher-order problem constellations: Executive Dysfunction, Compulsivity, Social Interaction Problems and Superficiality. All four constellations were positively correlated with life histories of aggression, stressing the clinical importance of these problems in adult forensic psychiatry. Compulsivity and Social Interaction Problems were associated with autistic traits and tics, Executive Dysfunction with AD/ HD, conduct disorder and psychopathic as well as autistic traits. Superficiality was a distinct aspect of AD/ HD and psychopathic traits, especially the PCL- R factor reflecting interpersonal callousness. Neuropsychiatric disorders and personality disorders such as psychopathy share common symptoms. The various facets of psychopathy are associated with executive dysfunction and empathy deficits with superficial understanding of self, others and the rules of communication.
C1 Lund Univ, Malmo Univ Hosp, Forens Psychiat Clin, SE-20502 Malmo, Sweden.
RP Anckarsater, HS (reprint author), Lund Univ, Malmo Univ Hosp, Forens Psychiat Clin, Sege Pk 8A, SE-20502 Malmo, Sweden.
EM henrik.anckarsater@skane.se
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NR 56
TC 3
Z9 3
PU TAYLOR & FRANCIS AS
PI OSLO
PA PO BOX 12 POSTHUSET, NO-0051 OSLO, NORWAY
SN 0803-9488
J9 NORD J PSYCHIAT
JI Nord. J. Psychiatr.
PD SEP
PY 2005
VL 59
IS 4
BP 246
EP 252
DI 10.1080/08039480500213709
PG 7
WC Psychiatry
SC Psychiatry
GA 964JI
UT WOS:000231876700004
ER
PT J
AU Madsen, KM
AF Madsen, KM
TI Vaccines and autism
SO NORDIC JOURNAL OF PSYCHIATRY
LA English
DT Book Review
C1 Univ Aarhus, Dept Epidemiol & Social Med, DK-8000 Aarhus, Denmark.
CR MADSEN KM, 2004, VACCINES AUTISM
NR 1
TC 0
Z9 0
PU TAYLOR & FRANCIS AS
PI OSLO
PA PO BOX 12 POSTHUSET, NO-0051 OSLO, NORWAY
SN 0803-9488
J9 NORD J PSYCHIAT
JI Nord. J. Psychiatr.
PD SEP
PY 2005
VL 59
IS 5
BP 422
EP 422
PG 1
WC Psychiatry
SC Psychiatry
GA 992SU
UT WOS:000233905100110
ER
PT J
AU Zimmerman, AW
Jyonouchi, H
Comi, AM
Connors, SL
Milstien, S
Varsou, A
Heyes, MP
AF Zimmerman, AW
Jyonouchi, H
Comi, AM
Connors, SL
Milstien, S
Varsou, A
Heyes, MP
TI Cerebrospinal fluid and serum markers of inflammation in autism
SO PEDIATRIC NEUROLOGY
LA English
DT Article
ID QUINOLINIC ACID; CYTOKINE PRODUCTION; INFANTILE-AUTISM; HUMAN MICROGLIA;
NITRIC-OXIDE; BIOPTERIN; NEOPTERIN; CHILDREN; METABOLITES; TRYPTOPHAN
AB Systemic immune abnormalities have no known relevance to brain dysfunction in autism. In order to find evidence for neuroinflammation, we compared levels of sensitive indicators of immune activation: quinolinic acid, neopterin, and biopterin, as well as multiple cytokines and cytokine receptors, in cerebrospinal fluid and serum from children with autism, to control subjects with other neurologic disorders. In cerebrospinal fluid from 12 children with autism, quinolinic acid (P = 0.037) and neopterin (P = 0.003) were decreased, and biopterin (P = 0.040) was elevated, compared with control subjects. In sera from 35 persons with autism, among cytokines, only tumor necrosis factor receptor II was elevated compared with controls (P < 0.02). Decreased quinolinic acid and neopterin in cerebrospinal fluid are paradoxical and suggest dysmaturation of metabolic pathways and absence of concurrent infection, respectively, in autism. Alternatively, they may be produced by microglia but remain localized and not expressed in cerebrospinal fluid. (c) 2005 by Elsevier Inc. All rights reserved.
C1 Kennedy Krieger Inst, Dept Neurol & Dev Med, Baltimore, MD 21205 USA.
Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA.
Univ Med & Dent New Jersey, New Jersey Med Sch, Dept Pediat, Newark, NJ 07103 USA.
NIMH, Bethesda, MD 20892 USA.
Univ Athens, Sch Med, GR-11527 Athens, Greece.
PsychoGen Inc, Hawthorne, NY USA.
RP Zimmerman, AW (reprint author), Kennedy Krieger Inst, Dept Neurol & Dev Med, 707 N Broadway, Baltimore, MD 21205 USA.
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NR 37
TC 103
Z9 105
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0887-8994
J9 PEDIATR NEUROL
JI Pediatr. Neurol.
PD SEP
PY 2005
VL 33
IS 3
BP 195
EP 201
DI 10.1016/j.pediatrneurol.2005.03.014
PG 7
WC Clinical Neurology; Pediatrics
SC Neurosciences & Neurology; Pediatrics
GA 967TN
UT WOS:000232114200007
PM 16139734
ER
PT J
AU Ross, AK
Hazlett, HC
Garrett, NT
Wilkerson, C
Piven, J
AF Ross, AK
Hazlett, HC
Garrett, NT
Wilkerson, C
Piven, J
TI Moderate sedation for MRI in young children with autism
SO PEDIATRIC RADIOLOGY
LA English
DT Article
DE autism; moderate sedation; pentobarbital; fentanyl
ID PEDIATRIC SEDATION; CHLORAL HYDRATE; ORAL KETAMINE; MANAGEMENT;
RADIOLOGY; EFFICACY
AB Autism is a pervasive neurodevelopmental disorder. Because of the deficits associated with the condition, sedation of children with autism has been considered more challenging than sedation of other children. Objective: To test this hypothesis, we compared children with autism against clinical controls to determine differences in requirements for moderate sedation for MRI. Materials and methods: Children ages 18-36 months with autism (group 1, n = 41) and children with no autistic behavior (group 2, n = 42) were sedated with a combination of pentobarbital and fentanyl per sedation service protocol. The sedation nurse was consistent for all patients, and all were sedated to achieve a Modified Ramsay Score of 4. Demographics and doses of sedatives were recorded and compared. Results: There were no sedation failures in either group. Children in group 1 (autism) were significantly older than group 2 (32.02 +/- 3.6 months vs 28.16 +/- 6.7 months) and weighed significantly more (14.87 +/- 2.1 kg vs 13.42 +/- 2.2 kg). When compared on a per-kilogram basis, however, group 1 had a significantly lower fentanyl requirement than group 2 (1.25 +/- 0.55 mcg/kg vs 1.57 +/- 10.81 mcg/kg), but no significant difference was found in pentobarbital dosing between groups 1 and 2, respectively (4.92 +/- 0.92 mg/kg vs 5.21 +/- 1.6 mg/kg). Conclusion: Autistic children in this age range are not more difficult to sedate and do not require higher doses of sedative agents for noninvasive imaging studies.
C1 Duke Univ, Med Ctr, Div Pediat Anesthesia, Durham, NC 27710 USA.
Univ N Carolina, Sch Med, Dept Psychiat, Chapel Hill, NC USA.
Duke Univ, Med Ctr, Dept Radiol, Durham, NC 27710 USA.
Univ N Carolina, Sch Med, Dept Pediat, Chapel Hill, NC USA.
RP Ross, AK (reprint author), Duke Univ, Med Ctr, Div Pediat Anesthesia, 3094, Durham, NC 27710 USA.
EM ross0016@mc.duke.edu
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NR 25
TC 13
Z9 13
PU SPRINGER
PI NEW YORK
PA 233 SPRING STREET, NEW YORK, NY 10013 USA
SN 0301-0449
J9 PEDIATR RADIOL
JI Pediatr. Radiol.
PD SEP
PY 2005
VL 35
IS 9
BP 867
EP 871
DI 10.1007/s00247-005-1499-2
PG 5
WC Pediatrics; Radiology, Nuclear Medicine & Medical Imaging
SC Pediatrics; Radiology, Nuclear Medicine & Medical Imaging
GA 956QA
UT WOS:000231313700006
PM 15902433
ER
PT J
AU Spencer, N
Devereux, E
Wallace, A
Sundrum, R
Shenoy, M
Bacchus, C
Logan, S
AF Spencer, N
Devereux, E
Wallace, A
Sundrum, R
Shenoy, M
Bacchus, C
Logan, S
TI Disabling conditions and registration for child abuse and neglect: A
population-based study
SO PEDIATRICS
LA English
DT Article
DE child abuse and neglect; disabling conditions; birth weight;
socioeconomic status
ID MALTREATMENT; DISABILITIES; ADOLESCENTS
AB Objective. To study the relationship between disabling conditions and registration for child abuse and neglect in a 19- year whole- population birth cohort
Setting. West Sussex area of the United Kingdom. Study Design. Retrospective whole- population cohort.
Main Outcomes. Child- protection registration, physical abuse, sexual abuse, emotional abuse, and neglect.
Population and Participants. Infants born in West Sussex ( 119 729) between January 1983 and December 2001 with complete data including birth weight, gestational age, maternal age, and postal code.
Results. Cerebral palsy, speech and language disorder, learning difficulties, conduct disorders, and nonconduct psychological disorders were all significantly associated with child- protection registration before adjustment, and all but cerebral palsy retained significance after adjustment for birth weight, gestational age, and socioeconomic status. Autism and sensory disabilities ( vision and hearing) were not associated with an increased risk of child- protection registration. Conduct disorders and moderate/ severe learning difficulty were associated with registration in each of the 4 categories after adjustment for socioeconomic status, birth weight, and gestational age. Children with speech and language disorders and mild learning difficulties were at increased risk of physical abuse, emotional abuse, and neglect. Nonconduct psychological disorders were associated with all categories except neglect, and cerebral palsy was associated with all categories except physical abuse and neglect.
Conclusions. Children with disabling conditions seem to be at increased risk of registration for child abuse and neglect, although the pattern of registration varies with the specific disabling condition. The strong association with registration noted for conditions such as conduct disorder and learning difficulties is likely to arise, in part, because these conditions share a common etiologic pathway with child abuse and neglect.
C1 Peninsula Med Sch, Inst Hlth & Social Care Res, Exeter EX1 2LU, Devon, England.
Univ Warwick, Sch Hlth & Social Studies, Dept Child Hlth, Coventry CV4 7AL, W Midlands, England.
Univ Warwick, Warwick Med Sch, Coventry CV4 7AL, W Midlands, England.
N Middlesex Hosp, Dept Child Hlth, London N18 1QX, England.
Ealing Primary Care Trust, Dept Child Hlth, Ealing, England.
Coventry Primary Care Trust, Dept Child Hlth, Coventry, W Midlands, England.
RP Logan, S (reprint author), Peninsula Med Sch, Inst Hlth & Social Care Res, Heavitree Rd, Exeter EX1 2LU, Devon, England.
EM stuart.logan@pms.ac.uk
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NR 19
TC 51
Z9 52
PU AMER ACAD PEDIATRICS
PI ELK GROVE VILLAGE
PA 141 NORTH-WEST POINT BLVD,, ELK GROVE VILLAGE, IL 60007-1098 USA
SN 0031-4005
J9 PEDIATRICS
JI Pediatrics
PD SEP
PY 2005
VL 116
IS 3
BP 609
EP 613
DI 10.1542/peds.2004-1882
PG 5
WC Pediatrics
SC Pediatrics
GA 960FW
UT WOS:000231576600032
PM 16140700
ER
PT J
AU McCaffery, P
Deutsch, CK
AF McCaffery, P
Deutsch, CK
TI Macrocephaly and the control of brain growth in autistic disorders
SO PROGRESS IN NEUROBIOLOGY
LA English
DT Review
DE autism; macrocephaly; genetic syndromes; brain size; nuclear receptor;
valproate; retinoic acid
ID FRAGILE-X-SYNDROME; NEURAL STEM-CELLS; FETAL VALPROATE SYNDROME;
RETINOIC ACID RECEPTORS; CENTRAL-NERVOUS-SYSTEM; CYCLASE-ACTIVATING
POLYPEPTIDE; DEXAMETHASONE SUPPRESSION TEST; BRONCHIAL EPITHELIAL-CELLS;
COMPLETE TRISOMY 5P; DENTATE GYRUS
AB Autism is a childhood-onset neuropsychiatric disorder characterized by marked impairments in social interactions and communication, with restricted stereotypic and repetitive patterns of behavior, interests, and activities. Genetic epidemiology studies indicate that a strong genetic component exists to this disease, but these same studies also implicate significant environmental influence. The disorder also displays symptomatologic heterogeneity, with broad individual differences and severity on a graded continuum. In the search for phenotypes to resolve heterogeneity and better grasp autism's underlying biology, investigators have noted a statistical overrepresentation of macrocephaly, an indicator of enlarged brain volume. This feature is one of the most widely replicated biological findings in autism. What then does brain enlargement signify? One hypothesis invoked for the origin of macrocephaly is a reduction in neuronal pruning and consolidation of synapses during development resulting in an overabundance of neurites. An increase in generation of cells is an additional mechanism for macrocephaly, though it is less frequently discussed in the literature. Here, we review neurodevelopmental mechanisms regulating brain growth and highlight one underconsidered potential causal mechanism for autism and macrocephaly-an increase in neurogenesis and/or gliogenesis. We review factors known to control these processes with an emphasis on nuclear receptor activation as one signaling control that may be abnormal and contribute to increased brain volume in autistic disorders. (c) 2005 Elsevier Ltd. All rights reserved.
C1 UMMS, EK Shriver Ctr, Waltham, MA USA.
Harvard Univ, Sch Med, Boston, MA 02115 USA.
RP McCaffery, P (reprint author), UMMS, EK Shriver Ctr, 200 Trapelo Rd, Waltham, MA USA.
EM peter.mccaffery@umassmed.edu
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NR 250
TC 51
Z9 53
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0301-0082
J9 PROG NEUROBIOL
JI Prog. Neurobiol.
PD SEP-OCT
PY 2005
VL 77
IS 1-2
BP 38
EP 56
DI 10.1016/j.pneurobio.2005.10.005
PG 19
WC Neurosciences
SC Neurosciences & Neurology
GA 994UC
UT WOS:000234055700002
PM 16280193
ER
PT J
AU Purandare, KN
Markar, TN
AF Purandare, KN
Markar, TN
TI Psychiatric symptomatology of Lujan-Fryns syndrome: an X-linked syndrome
displaying Marfanoid symptoms with autistic features, hyperactivity,
shyness and schizophreniform symptoms
SO PSYCHIATRIC GENETICS
LA English
DT Letter
DE autism; behaviour phenotype; Lujan-Fryns syndrome; Marfanoid habitus;
schizophrenia; X-linked mental retardation
ID MENTAL-RETARDATION; SCHIZOAFFECTIVE DISORDER; GENE LOCUS; HABITUS;
SUSCEPTIBILITY; ASSOCIATION; CHROMOSOME; LINKAGE; SCREEN; XP22.3
C1 Kingsbury Community Unit, London NW9 9QY, England.
Lister Hosp, Stevenage, Herts, England.
RP Purandare, KN (reprint author), Kingsbury Community Unit, Honeypot Lane, London NW9 9QY, England.
EM kiranpurandare03@yahoo.com
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NR 36
TC 8
Z9 8
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3261 USA
SN 0955-8829
J9 PSYCHIAT GENET
JI Psychiatr. Genet.
PD SEP
PY 2005
VL 15
IS 3
BP 229
EP 231
DI 10.1097/00041444-200509000-00016
PG 3
WC Genetics & Heredity; Neurosciences
SC Genetics & Heredity; Neurosciences & Neurology
GA 963MM
UT WOS:000231808400015
PM 16094260
ER
PT J
AU Abanilla, PK
Hannahs, GA
Wechsler, R
Silva, RR
AF Abanilla, PK
Hannahs, GA
Wechsler, R
Silva, RR
TI The use of psychostimulants in pervasive developmental disorders
SO PSYCHIATRIC QUARTERLY
LA English
DT Article
DE pervasive developmental disorder; mental retardation; attention deficit
hyperactivity disorder; stimulants
ID DEFICIT HYPERACTIVITY DISORDER; MENTALLY-RETARDED CHILDREN;
ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; METHYLPHENIDATE TREATMENT;
SCHIZOPHRENIC CHILDREN; ADHD; RETARDATION; EFFICACY; AUTISM; PDD
AB Many children with Pervasive Developmental Disorders (PDD) display problematic behaviors similar to those seen in children with Attention Deficit Hyperactivity Disorder (ADHD). This paper will look at the controversy concerning diagnosing comorbid ADHD in children who meet criteria for PDD and review the existing literature examining the efficacy of stimulants in these particular set of behaviors or symptom clusters (hyperactivity, impulsivity and inattention). The potential drawbacks of using stimulants in a population of children and adolescents who exhibit symptoms of PDD and ADHD will be discussed. Finally, this review will also attempt to define potential areas of future research to examine the utility of the psychostimulants in children and adolescents with PDD and symptoms of ADHD.
C1 NYU, Sch Med, Div Child & Adolescent Psychiat, New York, NY 10016 USA.
RP Abanilla, PK (reprint author), NYU, Sch Med, Div Child & Adolescent Psychiat, 550 1St Ave,NBV 21S6, New York, NY 10016 USA.
EM abanip01@med.nyu.edu
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NR 27
TC 2
Z9 2
PU KLUWER ACADEMIC-HUMAN SCIENCES PRESS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013-1578 USA
SN 0033-2720
J9 PSYCHIAT QUART
JI Psychiatr. Q.
PD FAL
PY 2005
VL 76
IS 3
BP 271
EP 281
DI 10.1007/s11126-005-2980-7
PG 11
WC Psychiatry
SC Psychiatry
GA 935NI
UT WOS:000229788600006
PM 16080422
ER
PT J
AU Schaller, J
Yang, NK
AF Schaller, J
Yang, NK
TI Competitive employment for people with autism: Correlates of successful
closure in competitive and supported employment
SO REHABILITATION COUNSELING BULLETIN
LA English
DT Article
ID REHABILITATION SERVICES; MENTAL-RETARDATION; DISABILITY; RACE
AB Differences in rates of case closure, case service cost, hours worked per week, and weekly wage between customers with autism closed successfully in competitive employment and supported employment were found using the Rehabilitation Service Administration national database of 2001. Using logistic regression, customer demographic variables related to successful competitive employment included age, years of education, and presence of a secondary disability. Case service variables related to successful competitive employment included job finding, job placement, and maintenance. Of customer demographic variables related to successful supported employment, White customers were more likely to be closed successfully. job placement was the case service variable related to successful supported employment. Implications for rehabilitation professionals and for future research on vocational rehabilitation outcomes with customers with autism are provided.
C1 Univ Texas, Masters Rehabil Counselor Educ Program, Austin, TX 78712 USA.
RP Schaller, J (reprint author), Univ Texas, Masters Rehabil Counselor Educ Program, Austin, TX 78712 USA.
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
Bolton BF, 2000, REHABIL COUNS BULL, V44, P10, DOI 10.1177/003435520004400103
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Yeargin-Allsopp M, 2003, JAMA-J AM MED ASSOC, V289, P49, DOI 10.1001/jama.289.1.49
NR 33
TC 14
Z9 14
PU PRO-ED INC
PI AUSTIN
PA 8700 SHOAL CREEK BLVD, AUSTIN, TX 78757-6897 USA
SN 0034-3552
J9 REHABIL COUNS BULL
JI Rehabil. Couns. Bull.
PD FAL
PY 2005
VL 49
IS 1
BP 4
EP 16
DI 10.1177/00343552050490010201
PG 13
WC Rehabilitation
SC Rehabilitation
GA 967NL
UT WOS:000232097800001
ER
PT J
AU Hastings, RP
Beek, A
Daley, D
Hill, C
AF Hastings, RP
Beek, A
Daley, D
Hill, C
TI Symptoms of ADHD and their correlates in children with intellectual
disabilities
SO RESEARCH IN DEVELOPMENTAL DISABILITIES
LA English
DT Article
DE intellectual disability; children; attention deficit hyperactivity
disorder; hyperkinesis
ID DEFICIT HYPERACTIVITY DISORDER; MENTALLY-RETARDED CHILDREN;
DEVELOPMENTAL BEHAVIOR CHECKLIST; FRAGILE-X-SYNDROME; ATTENTION-DEFICIT;
DIFFICULTIES QUESTIONNAIRE; PSYCHOMETRIC PROPERTIES; SELECTIVE
ATTENTION; PRESCHOOL-CHILDREN; CLASSROOM-BEHAVIOR
AB Existing research suggests that children with intellectual disabilities are at increased risk for ADHD, and that the symptoms of the disorder might successfully be treated with stimulant drugs. However, there has been little exploration of ADHD symptoms and their correlates in children with intellectual disabilities. Analyses of three samples of children with intellectual disabilities are presented (total N = 338). Correlational analyses showed that younger children, and those with a diagnosis of Autism were rated as having more ADHD/hyperactivity symptoms. There was little evidence of a sex difference, and no strong associations with domains of adaptive behavior (socialization, communication, and daily living skills). However, there was a small but significant negative association between mental age and ratings of symptoms. Finally, an increased prevalence of ADHD/hyperactivity symptoms was confirmed in the children with intellectual disabilities compared to their siblings. This effect remained after controlling for chronological and mental age differences between the siblings. These findings support those from previous research and suggest that ADHD/Hyperkinesis may be a valid psychiatric diagnosis for children with intellectual disabilities. However, a great deal more research is needed to explore the phenomenology of ADHD in intellectual disability and to develop an evidence base for psychosocial intervention. (c) 2004 Elsevier Ltd. All rights reserved.
C1 Univ Wales, Sch Psychol, Bangor LL57 2AS, Gwynedd, Wales.
RP Hastings, RP (reprint author), Univ Wales, Sch Psychol, Bangor LL57 2AS, Gwynedd, Wales.
EM r.hastings@bangor.ac.uk
RI Daley, David/G-3799-2011; Hastings, Richard/D-9657-2013
OI Hastings, Richard/0000-0002-0495-8270
CR Achenbach TM, 1991, MANUAL CHILD BEHAV C
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NR 63
TC 47
Z9 47
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0891-4222
J9 RES DEV DISABIL
JI Res. Dev. Disabil.
PD SEP-OCT
PY 2005
VL 26
IS 5
BP 456
EP 468
DI 10.1016/j.ridd.2004.10.003
PG 13
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA 970ZC
UT WOS:000232349900004
PM 16168883
ER
PT J
AU Cordeiro, Q
Vallada, H
AF Cordeiro, Q
Vallada, H
TI Genetics of autism
SO REVISTA BRASILEIRA DE PSIQUIATRIA
LA English
DT Letter
C1 Univ Sao Paulo, Dept Psychiat, BR-05508 Sao Paulo, Brazil.
RP Cordeiro, Q (reprint author), Univ Sao Paulo, Dept Psychiat, BR-05508 Sao Paulo, Brazil.
RI Vallada, Homero/D-1333-2014
OI Vallada, Homero/0000-0001-5123-8295
CR Auranen M, 2002, AM J HUM GENET, V71, P777, DOI 10.1086/342720
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*OMIM, 2002, NAT LIB MED
*OMIM, 2002, OMIM DAT INT
Philippe A, 1999, HUM MOL GENET, V8, P805, DOI 10.1093/hmg/8.5.805
NR 7
TC 0
Z9 0
PU ASSOCIACAO BRASILEIRA DE PSIQUIATRIA
PI SAO PAULO
PA SUBSCRIPTION DEPARTMENT, RUA PEDRO DE TOLEDO, 967 - CASA 01, SAO PAULO,
SP, BRAZIL
SN 1516-4446
J9 REV BRAS PSIQUIATR
JI Rev. Bras. Psiquiatr.
PD SEP
PY 2005
VL 27
IS 3
BP 257
EP 257
DI 10.1590/S1516-44462005000300022
PG 1
WC Psychiatry
SC Psychiatry
GA 973PC
UT WOS:000232534100023
PM 16224622
ER
PT J
AU Diez-Cuervo, A
Munoz-Yunta, JA
Fuentes-Biggi, J
Canal-Bedia, R
Idiazabal-Aletxa, MA
Ferrari-Arroyo, MJ
Mulas, F
Tamarit, J
Valdizan, JR
Hervas-Zuniga, A
Artigas-Pallares, J
Belinchon-Carmona, M
Hernandez, JM
Martos-Perez, J
Palacios, S
Posada-De la Paz, M
AF Diez-Cuervo, A
Munoz-Yunta, JA
Fuentes-Biggi, J
Canal-Bedia, R
Idiazabal-Aletxa, MA
Ferrari-Arroyo, MJ
Mulas, F
Tamarit, J
Valdizan, JR
Hervas-Zuniga, A
Artigas-Pallares, J
Belinchon-Carmona, M
Hernandez, JM
Martos-Perez, J
Palacios, S
Posada-De la Paz, M
CA Ministerio de Sanidad y Consumo Es
TI Best practice guidelines for the diagnosis of autistic spectrum
disorders
SO REVISTA DE NEUROLOGIA
LA Spanish
DT Article
DE autistic disorder; clinical protocols; diagnostic techniques and
procedures; DSM-IV; ICD; medical records; neurological diagnostic
techniques; practice guidelines; recommendations; routine diagnostic
tests
ID PERVASIVE DEVELOPMENTAL DISORDERS; MEDICAL CONDITIONS; EPIDEMIOLOGY;
DEPRESSION; INTERVIEW; CHILDREN; FAMILY
AB Introduction. The autism spectrum disorder (ASD) diagnostic process requires expertise both in the knowledge of autism as in teamwork strategies with different professionals, often working in different clinic services, and with parents. Aim. To recommend a consensus diagnostic procedure for ASD, that has been designed by the Study Group of the Instituto de Salud Carlos III. Development. The reports emphasize the need to obtain a complete clinical history, covering personal, family and psychosocial antecedents; detailing the basic areas affected in ASD - social interaction, communication and restricted patterns of behaviour activities and interests-. Diagnostic tests to be used as a routine in all cases are described and analysed - including both psychoeducational and biomedical tests-. Also, tests indicated in cases with suspected identifiable physical disorders are covered, as well as those medical tests to be used for research purposes only. Conclusion. The diagnostic procedure requires the implementation of a coordinated interdisciplinary assessment strategy, that needs to ensure the participation of professionals from very different fields in active collaboration with the family. Their role culminates in the preparation and delivery of a personalized report. Every diagnostic procedure needs to be accompanied by an action plan that includes immediate support to the person with ASD, as well as information to the family on resources and community initiatives in their living area.
C1 IMAS, Hosp Mar, Serv Neuropediat, Unidad Neuropediat, Barcelona, Spain.
Policlin Gipuzkoa & GAUTENA, Serv Psiquiatria Infantojuvenil, San Sebastian, Spain.
Univ Salamanca, Dept Personalidad Evaluac & Tratamiento Psicol, Fac Educ, E-37008 Salamanca, Spain.
Inst Neurocognit Incia & Clin Ntra, Barcelona, Spain.
Tecn Super IIER, ISCIII, Madrid, Spain.
INVANEP, Valencia, Spain.
Hosp Infantil la Fe, Serv Neuropediat, Valencia, Spain.
Hosp Univ Miguel Servet, Serv Neurofisiol Clin, Zaragoza, Spain.
Hosp Univ Miguel Servet, Unidad Trastornos Desarrollo, Zaragoza, Spain.
Clin Univ Dexeus, Hosp Mutua Terrassa, Ctr Salud Mental Infantojuvenil, Barcelona, Spain.
Hosp Sabadell, Unidad Neuropediat, Corp Sanitaria Parc Taulf, Sabadell, Spain.
Univ Autonoma Madrid, Fac Psicol, Dept Psicol Basica, E-28049 Madrid, Spain.
Univ Autonoma Madrid, Ctr Psicol Aplicada, E-28049 Madrid, Spain.
Consejeria Educ Comunidad Autonoma Madrid, Equipo Especif Alterac Graves Desarrollo, Madrid, Spain.
APNA, Serv Diagnost, Madrid, Spain.
Ctr Leo Kanner, Madrid, Spain.
Asociac Autismo Burgos, Burgos, Spain.
IIER, Inst Salud Carlos III, Unidad Sindrome Aceite Tox, E-28029 Madrid, Spain.
RP Ferrari-Arroyo, MJ (reprint author), IIER, Inst Salud Carlos III, Unidad Sindrome Aceite Tox, Pabellon 11,Sinesio Delgado 6, E-28029 Madrid, Spain.
EM mferrari@isciii.es
RI Canal Bedia, Ricardo/D-3116-2011
OI Canal Bedia, Ricardo/0000-0003-0247-0295
CR Asociacion Americana de Psiquiatria (APA), 2002, MAN DIAGN EST TRAST
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NR 39
TC 9
Z9 11
PU REVISTA DE NEUROLOGIA
PI BARCELONA
PA C/O CESAR VIGUERA, EDITOR, APDO 94121, 08080 BARCELONA, SPAIN
SN 0210-0010
J9 REV NEUROLOGIA
JI Rev. Neurologia
PD SEP 1
PY 2005
VL 41
IS 5
BP 299
EP 310
PG 12
WC Clinical Neurology
SC Neurosciences & Neurology
GA 971DB
UT WOS:000232360400009
PM 16138288
ER
PT J
AU Dannetun, E
Tegnell, A
Hermansson, G
Giesecke, J
AF Dannetun, E
Tegnell, A
Hermansson, G
Giesecke, J
TI Parents' reported reasons for avoiding MMR vaccination - A telephone
survey
SO SCANDINAVIAN JOURNAL OF PRIMARY HEALTH CARE
LA English
DT Article
DE attitudes; MMR; vaccination; parents
ID RUBELLA VACCINATION; MEASLES; MUMPS; IMMUNIZATION; CHILDREN; AUTISM;
POPULATION; DECISIONS; COVERAGE; DISEASE
AB Objective. During the second half of the 1990s and the first years of the 2000s a declining coverage for MMR vaccination in two-year-olds was observed in Sweden. The aim was to assess reasons for postponement or non-vaccination. Design. A telephone survey using a structured questionnaire on parents' attitudes regarding their choice to postpone or abstain from vaccinating their child. Setting. The County of Ostergotland in Sweden. Subjects. A total of 203 parents of children who had no registered date for MMR vaccination at a Child Health Centre. Main outcome measures. Parental reasons for non-vaccination. Results. In all, 26 of the 203 children had received MMR vaccination but this had not been registered. Of those not vaccinated, 40% of the parents had decided to abstain and 60% to postpone vaccination. Fear of side effects was the most common reason for non-vaccination in both groups. The main source of information was the media followed by the Child Health Centre. Parents with a single child more often postponed vaccination and those who abstained were more likely to have had a discussion with a doctor or nurse about MMR vaccine. Conclusion. Postponers and abstainers may have different reasons for their decision. The role of well-trained healthcare staff in giving advice and an opportunity to discuss MMR vaccination with concerned parents is very important.
C1 Landstinget & Ostergotland, Dept Communicable Dis Control, SE-58191 Linkoping, Sweden.
Natl Board Hlth & Welf, Communicable Dis Unit, Stockholm, Sweden.
Landstinget & Ostergotland, Cent Unit Child Hlth Care, Linkoping, Sweden.
Swedish Inst Infect Dis Control, Dept Epidemiol, Solna, Sweden.
RP Dannetun, E (reprint author), Landstinget & Ostergotland, Dept Communicable Dis Control, SE-58191 Linkoping, Sweden.
EM eva.dannetun@lio.se
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NR 17
TC 25
Z9 26
PU TAYLOR & FRANCIS AS
PI OSLO
PA PO BOX 12 POSTHUSET, NO-0051 OSLO, NORWAY
SN 0281-3432
J9 SCAND J PRIM HEALTH
JI Scand. J. Prim. Health Care
PD SEP
PY 2005
VL 23
IS 3
BP 149
EP 153
DI 10.1080/02813430510031306
PG 5
WC Health Care Sciences & Services; Medicine, General & Internal
SC Health Care Sciences & Services; General & Internal Medicine
GA 964JJ
UT WOS:000231876800006
PM 16162466
ER
PT J
AU Shanker, SG
Greenspan, SI
AF Shanker, SG
Greenspan, SI
TI The role of affect in language development
SO THEORIA-REVISTA DE TEORIA HISTORIA Y FUNDAMENTOS DE LA CIENCIA
LA English
DT Article
DE Functional/Emotional hypothesis; affective transformations; usage-based
linguistics; pattern-recognition; joint attention; learning-based
interactions; nativism; autism
ID SYNTAX
AB This paper presents the Functional/Emotional approach to language development, which explains the process leading up to the core capacities necessary for language (e.g., pattern-recognition, joint attention); shows how this process leads to the formation of internal symbols; and how it shapes and is shaped by the child's development of language. The heart of this approach is that, through a series of affective transformations, a child develops these core capacities and the capacity to form meaningful symbols. Far from being a sudden jump, the transition from prc-symbolic communication to language is enabled by the advances taking place in the child's affective gesturing.
C1 York Univ, Milton & Ethel Harris Res Initiat, N York, ON MJ3 1P3, Canada.
George Washington Med Ctr, Washington, DC 20037 USA.
RP Shanker, SG (reprint author), York Univ, Milton & Ethel Harris Res Initiat, 421 HNES, N York, ON MJ3 1P3, Canada.
EM shanker@yorku.ca; jantunney21@comcast.net
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NR 53
TC 0
Z9 0
PU SERVICIO EDITORIAL UNIVERSIDAD DEL PAIS VASCO
PI LEOIA
PA APARTDO 1397, E 48080 LEOIA, SPAIN
SN 0495-4548
J9 THEORIA-SPAIN
JI Theoria
PD SEP
PY 2005
VL 20
IS 3
BP 329
EP 343
PG 15
WC History & Philosophy Of Science
SC History & Philosophy of Science
GA 999ZP
UT WOS:000234431000007
ER
PT J
AU Jeffries, AR
Curran, S
Elmslie, F
Sharma, A
Wenger, S
Hummel, M
Powell, J
AF Jeffries, AR
Curran, S
Elmslie, F
Sharma, A
Wenger, S
Hummel, M
Powell, J
TI Molecular and phenotypic characterization of ring chromosome 22
SO AMERICAN JOURNAL OF MEDICAL GENETICS PART A
LA English
DT Article
DE ring chromosome 22; autism dysmorphology; del (22) (q13); human
development; molecular genetic characterization
ID PERVASIVE DEVELOPMENTAL DISORDERS; 22Q13 DELETION SYNDROME; DIFFICULTIES
QUESTIONNAIRE; EXPRESSION PATTERNS; MENTAL-RETARDATION; AUTISM; MOUSE;
GENE; FAMILY; BRAIN
AB We performed a phenotype study of 35 individuals (19 males, 16 females) with ring chromosome 22 or r(22) with a mean age of 10 years. In common with other studies, a phenotype of moderate-to-profound learning difficulties and delay or absence of speech affected all individuals with the exception of the case with the smallest deletion. Autistic traits were significantly associated with r(22), as shown by an autism screening questionnaire. Mild and variable dysmorphic features, predominantly craniofacial and distal limb, were observed. Internal organ involvement was uncommon. Even though ring chromosomes are reportedly associated with growth abnormalities, only 2 out of 24 individuals showed evidence of growth failure, while 2 showed accelerated growth. Chromosome 22 long arm deletions, as determined by hemizygosity for informative microsatellite markers, varied from < 67 kb to 10.2 Mb in size (or < 0.15 to 21% of total chromosome length), with no significant differences in the parental origin of the ring chromosome. Few phenotypic features correlated with deletion size suggesting a critical gene, or genes, of major effect lies close to the telomere. Loss of the SHANK3/PROSAP2 gene has been proposed to be responsible for the main neurological developmental deficits observed in 22q13 monosomies. This study supports this candidate gene by identifying a phenotypically normal r(22) individual whose ring chromosome does not disrupt SHANK3. All other r(22) individuals were hemizygous for SHANK3, and we propose it to be a candidate gene for autism or abnormal brain development. (c) 2005 Wiley-Liss, Inc.
C1 Inst Psychiat, Dept Psychol Med, Sect Brain Maturat, London SE5 8AF, England.
Inst Psychiat, Dept Neurosci, London, England.
Gen Hosp St Georg, Sch Med, Dept Med Genet, London, England.
Wilfred Sheldon Childrens Ctr, London, England.
W Virginia Univ, Dept Pathol, Morgantown, WV 26506 USA.
W Virginia Univ, Dept Pediat, Morgantown, WV 26506 USA.
RP Curran, S (reprint author), Inst Psychiat, Dept Psychol Med, Sect Brain Maturat, PO 50,Denmark Hill, London SE5 8AF, England.
EM s.curran@iop.kcl.ac.uk
RI Powell, John/G-4412-2011; Jeffries, Aaron/D-1256-2014
OI Powell, John/0000-0001-6124-439X; Jeffries, Aaron/0000-0002-1235-8291
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NR 64
TC 41
Z9 45
PU WILEY-LISS
PI HOBOKEN
PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 1552-4825
J9 AM J MED GENET A
JI Am. J. Med. Genet. A
PD AUG 30
PY 2005
VL 137A
IS 2
BP 139
EP 147
DI 10.1002/ajmg.a.30780
PG 9
WC Genetics & Heredity
SC Genetics & Heredity
GA 961AP
UT WOS:000231634600005
PM 16059935
ER
PT J
AU Dani, VS
Chang, Q
Maffei, A
Turrigiano, GG
Jaenisch, R
Nelson, SB
AF Dani, VS
Chang, Q
Maffei, A
Turrigiano, GG
Jaenisch, R
Nelson, SB
TI Reduced cortical activity due to a shift in the balance between
excitation and inhibition in a mouse model of Rett Syndrome
SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF
AMERICA
LA English
DT Article
DE autism; cortical circuit; MeCP2; mental retardation
ID LONG-TERM POTENTIATION; CPG-BINDING PROTEIN-2; PYRAMIDAL NEURONS; MECP2;
CORTEX; MICE; PLASTICITY; EXCITABILITY; DEFICIENCY; BRAIN
AB Rett Syndrome (RTT) is a devastating neurological disorder that is caused by mutations in the MECP2 gene. Mecp2-mutant mice have been used as a model system to study the disease mechanism. Our previous work has suggested that MeCP2 malfunction in neurons is the primary cause of RTT in the mouse. However, the neurophysiological consequences of MeCP2 malfunction remain obscure. Using whole-cell patch-clamp recordings in cortical slices, we show that spontaneous activity of pyramidal neurons is reduced in Mecp2-mutant mice. This decrease is not caused by a change in the intrinsic properties of the recorded neurons. Instead, the balance between cortical excitation and inhibition is shifted to favor inhibition over excitation. Moreover, analysis of the miniature excitatory postsynaptic currents (mEPSCs)/inhibitory postsynaptic currents (mIPSCs) in the Mecp2-mutant cortex reveals a reduction in mEPSC amplitudes, without significant change in the average mIPSC amplitude or frequency. These findings provide the first detailed electrophysiological analysis of Mecp2-mutant mice and provide a framework for understanding the pathophysiology of the disease and tools for studying the underlying disease mechanisms.
C1 Whitehead Inst Biomed Res, Cambridge, MA 02142 USA.
Brandeis Univ, Dept Biol, Waltham, MA 02454 USA.
Brandeis Univ, Volen Ctr Complex Syst, Waltham, MA 02454 USA.
MIT, Dept Biol, Cambridge, MA 02139 USA.
RP Jaenisch, R (reprint author), Whitehead Inst Biomed Res, 9 Cambridge Ctr, Cambridge, MA 02142 USA.
EM jaenisch@wi.mit.edu; nelson@brandeis.edu
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PU NATL ACAD SCIENCES
PI WASHINGTON
PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA
SN 0027-8424
J9 P NATL ACAD SCI USA
JI Proc. Natl. Acad. Sci. U. S. A.
PD AUG 30
PY 2005
VL 102
IS 35
BP 12560
EP 12565
DI 10.1073/pnas.0506071102
PG 6
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 961QC
UT WOS:000231675900050
PM 16116096
ER
PT J
AU Bauch, CT
AF Bauch, CT
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SO PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
LA English
DT Article
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diseases; vaccine scares; vaccination policy
ID MMR IMMUNIZATION; MEASLES; PERTUSSIS; PARENTS; CONTROVERSY; EPIDEMICS;
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C1 Univ Guelph, Dept Math & Stat, Guelph, ON N1G 2W1, Canada.
RP Bauch, CT (reprint author), Univ Guelph, Dept Math & Stat, Guelph, ON N1G 2W1, Canada.
EM cbauch@uoguelph.ca
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NR 53
TC 69
Z9 72
PU ROYAL SOC
PI LONDON
PA 6-9 CARLTON HOUSE TERRACE, LONDON SW1Y 5AG, ENGLAND
SN 0962-8452
J9 P ROY SOC B-BIOL SCI
JI Proc. R. Soc. B-Biol. Sci.
PD AUG 22
PY 2005
VL 272
IS 1573
BP 1669
EP 1675
DI 10.1098/rspb.2005.3153
PG 7
WC Biology; Ecology; Evolutionary Biology
SC Life Sciences & Biomedicine - Other Topics; Environmental Sciences &
Ecology; Evolutionary Biology
GA 962AM
UT WOS:000231703400006
PM 16087421
ER
PT J
AU Hernandez, JM
Artigas-Pallares, J
Martos-Perez, J
Palacios-Anton, S
Fuentes-Biggi, J
Belinchon-Carmona, M
Canal-Bedia, R
Diez-Cuervo, A
Ferrari-Arroyo, MJ
Hervas-Zuniga, A
Idiazabal-Alecha, MA
Mulas, F
Munoz-Yunta, JA
Tamarit, J
Valdizan, JR
Posada-De la Paz, M
AF Hernandez, JM
Artigas-Pallares, J
Martos-Perez, J
Palacios-Anton, S
Fuentes-Biggi, J
Belinchon-Carmona, M
Canal-Bedia, R
Diez-Cuervo, A
Ferrari-Arroyo, MJ
Hervas-Zuniga, A
Idiazabal-Alecha, MA
Mulas, F
Munoz-Yunta, JA
Tamarit, J
Valdizan, JR
Posada-De la Paz, M
CA Grp Estudio Trastornos Espectro Au
TI Best practice guidelines for the early detection of autistic spectrum
Disorders (I)
SO REVISTA DE NEUROLOGIA
LA Spanish
DT Article
DE autistic disorder; diagnostic techniques and procedures; diagnostic
tools; early diagnosis; early intervention; mass screening; needs
assessment; practice guidelines; red flags; risk factors; sensitivity
and specificity
ID HIGH-FUNCTIONING AUTISM; SCHOOL-AGE-CHILDREN; ASPERGER-SYNDROME; EARLY
RECOGNITION; DIAGNOSIS; CHECKLIST; INFANCY
AB Introduction. The interest in early detection of autism spectrum Disorders (ASD) lies in the accumulated evidence of the fact that an early customized intervention for children with an ASD and their families leads to an improvement of the child's prognosis in most cases. Objective. To establish criteria and procedures for early identification of children at risk of ASD and to facilitate full diagnostic assessment and prompt referral leading to adequate support. Early detection of ASD is extremely important, since early specific individualized treatment,for the child and his or her,family leads to long-term improvement in many children' prognosis. Development. Firstly; a critical appraisal of the situation of early detection of ASD in Spain is made after reviewing the scarce bibliography available on current screening and diagnostic practices in the country Data generated by questionnaires received from 646 Spanish families is also taken into account. Secondly; the Study Group of the Instituto de Salad Carlos III recommends the screening and early diagnosis process to be followed, describing the necessary steps, the public services involved and the available screening and diagnostic tools. Conclusions. The Study Group draws the main conclusions regarding the situation of ASD early detection in Spain, and makes a consensus proposal for the detection procedures, including routine developmental surveillance and identification of children at risk for ASD by using sensitive and specific assessment tools.
C1 Inst Salud Carlos III, Tecn Super IIER, E-28029 Madrid, Spain.
Consejeria Educ Comun Autonoma Madrid, Equipo Especif Alterac Graves Desarrollo, Madrid, Spain.
Hosp Sabadell, Corp Sanitaria Parc Tauli, Unidad Neuropediat, Sabadell, Spain.
APNA, Serv Diagnost, Madrid, Spain.
Ctr Leo Kanner, Madrid, Spain.
Asociac Autismo Burgos, Burgos, Spain.
Polclin Gipuzkoa, Serv Psiquiatria Infantojuvenil, San Sebastian, Spain.
GAUTENA, San Sebastian, Spain.
Univ Autonoma Madrid, Fac Psicol, Dept Psicol Basica, Madrid, Spain.
Univ Autonoma Madrid, Ctr Psicol Aplicada, Madrid, Spain.
Univ Salamanca, Dept Personal Evaluac & Tratamiento Psicol, Fac Educ, E-37008 Salamanca, Spain.
Clin Univ Dexeus, Ctr Salud Mental Infantojuvenil, Hosp Mutua Terrassa, Barcelona, Spain.
Inst Neurocognit Incia & Clin Ntra Sra Pilar, Barcelona, Spain.
INVANEP, Valencia, Spain.
Hosp Infantil la Fe, Serv Neuropediat, Valencia, Spain.
Hosp del Mar, IMAS, Unidad Neuropediat, Serv Neuropediat, Barcelona, Spain.
Hosp Univ Miguel Servet, Dept Cal, FEAPS, Zaragoza, Spain.
Hosp Univ Miguel Servet, Serv Neurofisiol Clin, Zaragoza, Spain.
Hosp Univ Miguel Servet, Unidad Trastornos Desarrollo, Zaragoza, Spain.
ISC111, Unidad Sindrome Aceite Toxico, IIER, Madrid, Spain.
RP Ferrari-Arroyo, MJ (reprint author), Inst Salud Carlos III, Tecn Super IIER, Pabellon 11,Sinesio Delgado,6, E-28029 Madrid, Spain.
EM mferrari@isciii.es
RI Canal Bedia, Ricardo/D-3116-2011
OI Canal Bedia, Ricardo/0000-0003-0247-0295
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NR 24
TC 10
Z9 13
PU REVISTA DE NEUROLOGIA
PI BARCELONA
PA C/O CESAR VIGUERA, EDITOR, APDO 94121, 08080 BARCELONA, SPAIN
SN 0210-0010
J9 REV NEUROLOGIA
JI Rev. Neurologia
PD AUG 16
PY 2005
VL 41
IS 4
BP 237
EP 245
PG 9
WC Clinical Neurology
SC Neurosciences & Neurology
GA 962CX
UT WOS:000231709700008
PM 16075402
ER
PT J
AU Hileman, B
AF Hileman, B
TI Biomonitoring
SO CHEMICAL & ENGINEERING NEWS
LA English
DT Article
AB The Centers for Disease Control and Prevention biomonitoring studies, issued every 2 years, gives researchers new opportunities to learn whether low levels of industrial chemicals such as phthalate and thimerosal might be responsible for certain disturbing health trends. For example, incidences of testicular cancer, autism, attention deficit disorder and male birth defects have all increased over the last few decades.
NR 0
TC 0
Z9 0
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0009-2347
J9 CHEM ENG NEWS
JI Chem. Eng. News
PD AUG 15
PY 2005
VL 83
IS 33
BP 35
EP 35
PG 1
WC Chemistry, Multidisciplinary; Engineering, Chemical
SC Chemistry; Engineering
GA 954XM
UT WOS:000231188800042
ER
PT J
AU Shamay-Tsoory, SG
Lester, H
Chisin, R
Israel, O
Bar-Shalom, R
Peretz, A
Tomer, R
Tsitrinbaum, Z
Aharon-Peretz, J
AF Shamay-Tsoory, SG
Lester, H
Chisin, R
Israel, O
Bar-Shalom, R
Peretz, A
Tomer, R
Tsitrinbaum, Z
Aharon-Peretz, J
TI The neural correlates of understanding the other's distress: A positron
emission tomography investigation of accurate empathy
SO NEUROIMAGE
LA English
DT Article
DE empathy; positron emission tomography; theory of mind; simulation
ID ASPERGER-SYNDROME; MIND; BRAIN; AUTISM; COMPREHENSION; IMITATION;
DEFICITS; ADULTS; TASKS; FMRI
AB The purpose of the present study was to assess the relationship between brain metabolism and empathic response. Six right-handed healthy volunteers were scanned with PET and fluorodeoxyglucose twice: during an interview about neutral story themes and during an empathic response eliciting interview about a story of a character in distress. Metabolic values in the medial and superior frontal gyrus, occipitotemporal cortices, thalamus and the cerebellum were higher during empathic response than during the neutral theme interview. Furthermore, the subjects' empathy scores were positively correlated with metabolism in the medial aspects of the superior frontal gyros. Our results suggest that empathy consists of both affective and cognitive components and hence may involve cortices that mediate simulation of emotional processing and mental state attribution. (c) 2005 Elsevier Inc. All rights reserved.
C1 Univ Haifa, Dept Psychol, IL-31905 Haifa, Israel.
Hadassah Hebrew Univ Hosp, Dept Radiol, Jerusalem, Israel.
GE Healthcare, Tirat Carmel, Israel.
RP Shamay-Tsoory, SG (reprint author), Univ Haifa, Dept Psychol, IL-31905 Haifa, Israel.
EM sshamay@psy.haifa.ac.il
RI tomer, rachel/E-5747-2013
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NR 34
TC 34
Z9 34
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 1053-8119
J9 NEUROIMAGE
JI Neuroimage
PD AUG 15
PY 2005
VL 27
IS 2
BP 468
EP 472
DI 10.1016/j.neuroimage.2005.05.012
PG 5
WC Neurosciences; Neuroimaging; Radiology, Nuclear Medicine & Medical
Imaging
SC Neurosciences & Neurology; Radiology, Nuclear Medicine & Medical Imaging
GA 954KV
UT WOS:000231154900020
PM 15987670
ER
PT J
AU Lawton, G
AF Lawton, G
TI The autism myth
SO NEW SCIENTIST
LA English
DT Article
AB Autism is widely perceived to be spiralling out of control and some say it mayeven be reaching epidemic proportions.
NR 0
TC 0
Z9 0
PU REED BUSINESS INFORMATION LTD
PI SUTTON
PA QUADRANT HOUSE THE QUADRANT, SUTTON SM2 5AS, SURREY, ENGLAND
SN 0262-4079
J9 NEW SCI
JI New Sci.
PD AUG 13
PY 2005
VL 187
IS 2512
BP 36
EP 40
PG 5
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 956ZY
UT WOS:000231340100036
ER
PT J
AU Wilson, C
AF Wilson, C
TI What is autism?
SO NEW SCIENTIST
LA English
DT Editorial Material
NR 0
TC 0
Z9 0
PU REED BUSINESS INFORMATION LTD
PI SUTTON
PA QUADRANT HOUSE THE QUADRANT, SUTTON SM2 5AS, SURREY, ENGLAND
SN 0262-4079
J9 NEW SCI
JI New Sci.
PD AUG 13
PY 2005
VL 187
IS 2512
BP 39
EP 39
PG 1
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 956ZY
UT WOS:000231340100037
ER
PT J
AU Yamasue, H
Ishijima, M
Abe, O
Sasaki, T
Yamada, H
Suga, M
Rogers, M
Minowa, I
Someya, R
Kurita, H
Aoki, S
Kato, N
Kasai, K
AF Yamasue, H
Ishijima, M
Abe, O
Sasaki, T
Yamada, H
Suga, M
Rogers, M
Minowa, I
Someya, R
Kurita, H
Aoki, S
Kato, N
Kasai, K
TI Neuroanatomy in monozygotic twins with Asperger disorder discordant for
comorbid depression
SO NEUROLOGY
LA English
DT Editorial Material
ID AUTISM
C1 Univ Tokyo, Grad Sch Med, Dept Neuropsychiat, Bunkyo Ku, Tokyo 1138655, Japan.
Univ Tokyo, Grad Sch Med, Dept Radiol, Tokyo 1138655, Japan.
Univ Tokyo, Grad Sch Med, Dept Mental Hlth, Tokyo 1138655, Japan.
RP Yamasue, H (reprint author), Univ Tokyo, Grad Sch Med, Dept Neuropsychiat, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1138655, Japan.
EM yamasue-tky@umin.ac.jp
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Yamasue H, 2003, P NATL ACAD SCI USA, V100, P9039, DOI 10.1073/pnas.1530467100
NR 7
TC 10
Z9 11
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0028-3878
J9 NEUROLOGY
JI Neurology
PD AUG 9
PY 2005
VL 65
IS 3
BP 491
EP 492
DI 10.1212/01.wnl.0000172360.99310.3f
PG 2
WC Clinical Neurology
SC Neurosciences & Neurology
GA 953HM
UT WOS:000231067200037
PM 16087928
ER
PT J
AU Prasad, HC
Zhu, CB
McCauley, JL
Samuvel, DJ
Ramamoorthy, S
Shelton, RC
Hewlett, WA
Sutcliffe, JS
Blakely, RD
AF Prasad, HC
Zhu, CB
McCauley, JL
Samuvel, DJ
Ramamoorthy, S
Shelton, RC
Hewlett, WA
Sutcliffe, JS
Blakely, RD
TI Human serotonin transporter variants display altered sensitivity to
protein kinase G and p38 mitogen-activated protein kinase
SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF
AMERICA
LA English
DT Article
DE transport; antidepressant; polymorphism; regulation; autism
ID HUMAN DOPAMINE TRANSPORTER; GENOMEWIDE SCREEN; 5-HTT GENE; AUTISM;
EXPRESSION; REGION; PHOSPHORYLATION; TRAFFICKING; COCAINE; BRAIN
AB Human serotonin [5-hydroxytryptamine (5-HT)] transporters (hSERT, 5HTT, and SLC6A4) inactivate 5-HT after release and are prominent targets for therapeutic intervention in mood, anxiety, and obsessive-compulsive disorders. Multiple hSERT coding variants have been identified, although to date no comprehensive functional analysis of these variants has been reported. We transfected hSERT or 10 hSERT coding variants and examined total and surface protein expression, antagonist recognition, and transporter modulation by posttranslational, regulatory pathways. Two variants, Pro339Leu and lle425Val, demonstrated significant changes in surface expression supporting alterations in 5-HT transport capacity V-max). Regardless of basal transport activity, all SERT variants displayed a capacity for rapid, phorbol ester-triggered down-regulation. Remarkably, five variants (Thr4Ala, Gly56Ala, Glu215Lys, Lys605Asn, and Pro612Ser) demonstrated no capacity for 5-HT uptake stimulation after acute protein kinase G (PKG)/p38 mitogen-activated protein kinase (MAPK) activation. Epstein-Barr virus (EBV)-transformed lymphocytes natively expressing the most common of these variants (Gly56AIa) exhibited a similar loss of 5-HT uptake stimulation by PKG/p38 MAPK activators. HeLa cells transfected with the Gly56AIa variant demonstrated elevated basal phosphorylation and, unlike hSERT, could not be further phosphorylated after 8-bromo cGMP (8BrcGMP) treatments. These studies reveal cellular phenotypes associated with naturally occurring human SERT coding variants and suggest that altered transporter regulation by means of PKG/p38 MAPK-linked pathways may influence risk for disorders attributed to compromised 5-HT signaling.
C1 Vanderbilt Univ, Sch Med, Vanderbilt Ctr Mol Neurosci, Dept Pharmacol, Nashville, TN 37232 USA.
Vanderbilt Univ, Sch Med, Dept Mol Physiol & Biophys, Nashville, TN 37232 USA.
Vanderbilt Univ, Sch Med, Dept Psychiat, Nashville, TN 37232 USA.
Vanderbilt Univ, Sch Med, Ctr Human Genet Res, Nashville, TN 37232 USA.
Vanderbilt Univ, Sch Med, Ctr Mol Neurosci, Nashville, TN 37232 USA.
Med Univ S Carolina, Dept Neurosci, Charleston, SC 29425 USA.
RP Blakely, RD (reprint author), Vanderbilt Univ, Sch Med, Vanderbilt Ctr Mol Neurosci, Dept Pharmacol, Suite 7140,MRB3, Nashville, TN 37232 USA.
EM randy.blakely@vanderbilt.edu
RI Sutcliffe, James/C-1348-2012
OI Sutcliffe, James/0000-0001-5200-6007
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NR 54
TC 92
Z9 95
PU NATL ACAD SCIENCES
PI WASHINGTON
PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA
SN 0027-8424
J9 P NATL ACAD SCI USA
JI Proc. Natl. Acad. Sci. U. S. A.
PD AUG 9
PY 2005
VL 102
IS 32
BP 11545
EP 11550
DI 10.1073/pnas.0501432102
PG 6
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 955UP
UT WOS:000231253400074
PM 16055563
ER
PT J
AU Thompson, JV
Best, AR
Wilson, DA
AF Thompson, JV
Best, AR
Wilson, DA
TI Ontogeny of cortical synaptic depression underlying olfactory sensory
gating in the rat
SO DEVELOPMENTAL BRAIN RESEARCH
LA English
DT Article
DE sensory systems; olfactory senses; metabotropic glutamate receptor;
piriform cortex; synaptic depression; sensory gating; autism
ID PIRIFORM CORTEX; HABITUATION; SYSTEM
AB Sensory gating is the ability to filter irrelevant or redundant sensory input and is a critical function of all sensory systems that allows efficient processing of important stimuli. The present results demonstrate that a form of activity-dependent synaptic depression recently found to be involved in both cortical and behavioral olfactory sensory gating, is functional by at least the first postnatal week in the rat piriform cortex, and shares a common metabotropic glutamate receptor mechanism. (c) 2005 Elsevier B.V. All rights reserved.
C1 Univ Oklahoma, Dept Zool, Norman, OK 73019 USA.
RP Wilson, DA (reprint author), Univ Oklahoma, Dept Zool, Norman, OK 73019 USA.
EM dwilson@ou.edu
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NR 18
TC 4
Z9 4
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0165-3806
J9 DEV BRAIN RES
JI Dev. Brain Res.
PD AUG 8
PY 2005
VL 158
IS 1-2
BP 107
EP 110
DI 10.1016/j.devbrainres.2005.05.006
PG 4
WC Developmental Biology; Neurosciences
SC Developmental Biology; Neurosciences & Neurology
GA 960OX
UT WOS:000231604100014
ER
PT J
AU Lobdell, DT
Mendola, P
AF Lobdell, DT
Mendola, P
TI Development of a biomarkers database for the National Children's Study
SO TOXICOLOGY AND APPLIED PHARMACOLOGY
LA English
DT Article; Proceedings Paper
CT International Conference on Biomarkers for Toxicology and Molecular
Epidemiology
CY MAR 15, 2004
CL Atlanta, GA
DE biomarkers; children; environmental health; database
AB The National Children's Study (NCS) is a federally-sponsored, longitudinal study of environmental influences on the health and development of children across the United States (www.nationalchildrensstudy.gov). Current plans are to study approximately 100,000 children and their families beginning before birth up to age 21 years. To explore potential biomarkers that could be important measurements in the NCS, we compiled the relevant scientific literature to identify both routine or standardized biological markers as well as new and emerging biological markers. Although the search criteria encouraged examination of factors that influence the breadth of child health and development, attention was primarily focused on exposure, susceptibility, and outcome biomarkers associated with four important child health outcomes: autism and neurobehavioral disorders, injury, cancer, and asthma. The Biomarkers Database was designed to allow users to: (1) search the biomarker records compiled by type of marker (susceptibility, exposure or effect), sampling media (e.g., blood, urine, etc.), and specific marker name; (2) search the citations file; and (3) read the abstract evaluations relative to our search criteria. A searchable, user-friendly database of over 2000 articles was created and is publicly available at: http://cfpub.epa.gov/ncea/cfm/recordisplay.cfm?deid=85844. PubMed was the primary source of references with some additional searches of Toxline, NTIS, and other reference databases. Our initial focus was on review articles, beginning as early as 1996, supplemented with searches of the recent primary research literature from 2001 to 2003. We anticipate this database will have applicability for the NCS as well as other studies of children's environmental health. Published by Elsevier Inc.
C1 US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Human Studies Div,Epidemiol & Biomarkers Branch, Res Triangle Pk, NC 27711 USA.
RP Mendola, P (reprint author), US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Human Studies Div,Epidemiol & Biomarkers Branch, MD 58A, Res Triangle Pk, NC 27711 USA.
EM mendola.pauline@epa.gov
CR BRANUM AM, 2003, ENV HLTH PERSPECT, V111, P640
*NAT LIB MED, US NAT LIB MED MEDLI
NR 2
TC 5
Z9 5
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0041-008X
J9 TOXICOL APPL PHARM
JI Toxicol. Appl. Pharmacol.
PD AUG 7
PY 2005
VL 206
IS 2
BP 269
EP 273
DI 10.1016/j.taap.2004.07.016
PG 5
WC Pharmacology & Pharmacy; Toxicology
SC Pharmacology & Pharmacy; Toxicology
GA 945UP
UT WOS:000230528000023
PM 15967218
ER
PT J
AU Curran, S
Roberts, S
Thomas, S
Veltman, M
Browne, J
Medda, E
Pickles, A
Sham, P
Bolton, PF
AF Curran, S
Roberts, S
Thomas, S
Veltman, M
Browne, J
Medda, E
Pickles, A
Sham, P
Bolton, PF
TI An association analysis of microsatellite markers across the
Prader-Willi/Angelman critical region on chromosome 15 (q11-13) and
autism spectrum disorder
SO AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
LA English
DT Article
DE autism; chromosome 15; linkage disequilibrium; transmission
disequilibrium test
ID RECEPTOR SUBUNIT GENES; LINKAGE-DISEQUILIBRIUM; FAMILIES; 15Q11-Q13
AB Autism (OMIM 209850) is a neurodevelopmental disorder with a significant genetic component of a complex nature. Cytogenetic abnormalities in the Prader-Willi/Angelman syndrome critical region (PWACR) on chromosome 15 (q11-13) have been described in several individuals with autism. We have examined five microsatellite markers spread across the 4 Mb PWACR for linkage disequilibrium (LD) in 148 families with autism spectrum disorder (ASD) and a subset of 82 families with autism using the extended transmission disequilibrium test (ETDT). The markers examined were D15S11, D15S128, D15S1506, GABRB3, and D15S1002. In addition we have examined the microsatellite D15S822 for hemizygous deletion status in our sample as it had been previously reported to be increased in autism. We found no significant LD with any of the markers tested either in the ASD or autism families when looking at paternal and maternal meioses combined. However, as there are known imprinted genes in the region, including possibly GABRB3, we also examined for LD in paternal and maternal meioses separately. Examining paternal transmissions only, we found marginal evidence for LD with a protective allele at marker D15S11 in the ASD families (Chi-sq 7 df, P = 0.05) and marginal evidence for risk alleles at markers D15S1506 (Chi-sq 13.7, 6 df, P = 0.06), GABRB3 (Chi-sq 15.9, 8 df, P = 0.11) and D15S1002 (Chi-sq 17.7, 9 df, P = 0.08) in the autism only families. The allele responsible for the association with GABRB3 is the 191 allele which was previously reported to be overtransmitted. Hemizygous deletion of the microsatellite D15S822 was found in 3 out of 340 independent chromosomes in our sample; a rate of 0.8%. This is not significantly different to the frequency in the general population. In conclusion, our results did not rule out the involvement of this chromosomal region, but provided further evidence, albeit very limited, to implicate GABRB3. Further more systematic work in larger samples is required and confirmation that GABRB3 is imprinted is desirable. (c) 2005 Wiley-Liss, Inc.
C1 Inst Psychiat, Dept Med Psychol P050, London SE5 8AF, England.
Inst Psychiat, MRC Social Genet & Dev Psychiat Ctr, London SE5 8AF, England.
Salisbury Dist Hosp, Wessex Reg Genet Lab, Salisbury, Wilts, England.
Southampton Gen Hosp, Paediat Med Unit, Southampton SO9 4XY, Hants, England.
Ist Super Sanita, Lab Epidemiol & Biostat Emanuela Medda, I-00161 Rome, Italy.
Univ Manchester, Ctr Census & Survey Res, Manchester, Lancs, England.
Univ Cambridge, Sect Dev Psychiat, Cambridge, England.
RP Curran, S (reprint author), Inst Psychiat, Dept Med Psychol P050, De Crespigny Pk, London SE5 8AF, England.
EM s.curran@iop.kcl.ac.uk
RI Pickles, Andrew/A-9625-2011; Bolton, Patrick/E-8501-2010
OI Pickles, Andrew/0000-0003-1283-0346; Bolton, Patrick/0000-0002-5270-6262
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NR 20
TC 24
Z9 27
PU WILEY-LISS
PI HOBOKEN
PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 1552-4841
J9 AM J MED GENET B
JI Am. J. Med. Genet. B
PD AUG 5
PY 2005
VL 137B
IS 1
BP 25
EP 28
DI 10.1002/ajmg.b.30126
PG 4
WC Genetics & Heredity; Psychiatry
SC Genetics & Heredity; Psychiatry
GA 951HW
UT WOS:000230921200005
PM 15952184
ER
PT J
AU Kujala, T
Lepisto, T
Nieminen-von Wendt, T
Naatanen, P
Naatanen, R
AF Kujala, T
Lepisto, T
Nieminen-von Wendt, T
Naatanen, P
Naatanen, R
TI Neurophysiological evidence for cortical discrimination impairment of
prosody in Asperger syndrome
SO NEUROSCIENCE LETTERS
LA English
DT Article
DE Asperger syndrome; prosody; emotion; mismatch negativity; auditory
processing
ID HIGH-FUNCTIONING AUTISM; SPECTRUM DISORDERS; MIND; CHILDREN; SPEECH;
ADULTS
AB Asperger syndrome (AS), belonging to the autism spectrum of disorders, is one of the pervasive developmental disorders. Individuals with AS usually have normal development of formal speech but pronounced problems in perceiving and producing speech prosody. The present study addressed the discrimination of speech prosody in AS by recording the mismatch negativity (MMN) and behavioural responses to natural utterances with different emotional connotations. MMN responses were abnormal in the adults with AS in several ways. In these subjects, fewer significantly elicited MMNs, diminished MMN amplitudes, as well as prolonged latencies were found. In addition, the MMN generator loci differed between the subjects with AS and control subjects. These findings were predominant over the right cerebral hemisphere. These results show impaired neurobiological basis for speech-prosody processing at an early, pre-attentive auditory discrimination stage in AS. (c) 2005 Elsevier Ireland Ltd. All rights reserved.
C1 Univ Helsinki, Helsinki Collegium Adv Studies, Helsinki, Finland.
Univ Helsinki, Dept Psychol, Cognit Brain Res Unit, FIN-00014 Helsinki, Finland.
Univ Helsinki, Helsinki Brain Res Ctr, Helsinki, Finland.
Helsinki Univ Hosp, Hosp Children & Adolescents, Dept Child Neurol, Helsinki, Finland.
Univ Helsinki, Dept Psychol, SF-00100 Helsinki, Finland.
RP Kujala, T (reprint author), Univ Helsinki, Helsinki Collegium Adv Studies, Helsinki, Finland.
EM teija.m.kujala@helsinki.fi
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NR 22
TC 62
Z9 63
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
IRELAND
SN 0304-3940
J9 NEUROSCI LETT
JI Neurosci. Lett.
PD AUG 5
PY 2005
VL 383
IS 3
BP 260
EP 265
DI 10.1016/j.neulet.2005.04.048
PG 6
WC Neurosciences
SC Neurosciences & Neurology
GA 940LJ
UT WOS:000230145700013
PM 15885908
ER
PT J
AU Bora, E
Vahip, S
Gonul, AS
Akdeniz, F
Alkan, M
Ogut, M
Eryavuz, A
AF Bora, E
Vahip, S
Gonul, AS
Akdeniz, F
Alkan, M
Ogut, M
Eryavuz, A
TI Evidence for theory of mind deficits in euthymic patients with bipolar
disorder
SO ACTA PSYCHIATRICA SCANDINAVICA
LA English
DT Article
DE bipolar disorder; social cognition; executive functions; attention
ID HIGH-FUNCTIONING ADULTS; SOCIAL COGNITION; EXECUTIVE FUNCTION;
ASPERGER-SYNDROME; SCHIZOPHRENIA; AUTISM; PEOPLE; IMPAIRMENTS;
SYMPTOMATOLOGY; RECOGNITION
AB i) To investigate the subtle ToM (theory of mind) deficits in euthymic patients with bipolar disorder. ii) To investigate the impact of non-ToM cognitive deficits on ToM abilities.
Forty-three euthymic patients with bipolar disorder and 30 healthy control subjects were involved in this study. ToM was assessed by the Eyes test and the Hinting task. Both groups were also evaluated with a comprehensive neuropsychological battery including tasks for basic emotion and face recognition.
The patient group was impaired on both of the ToM tasks. The patient group also showed impairment in many cognitive tasks including tasks related to sustained attention.
Even euthymic patients with bipolar disorder may be impaired in advanced ToM tasks. Executive dysfunction and some other cognitives deficits such as basic emotion recognition may be at least partly responsible for this result.
C1 Ege Univ, TR-35100 Izmir, Turkey.
RP Bora, E (reprint author), Ege Univ, TR-35100 Izmir, Turkey.
EM emrebora@hotmail.com
RI bora, emre/D-4123-2009
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NR 42
TC 121
Z9 122
PU BLACKWELL PUBLISHING
PI OXFORD
PA 9600 GARSINGTON RD, OXFORD OX4 2DG, OXON, ENGLAND
SN 0001-690X
J9 ACTA PSYCHIAT SCAND
JI Acta Psychiatr. Scand.
PD AUG
PY 2005
VL 112
IS 2
BP 110
EP 116
DI 10.1111/j.1600-0447.2005.00570.x
PG 7
WC Psychiatry
SC Psychiatry
GA 942OP
UT WOS:000230292000005
PM 15992392
ER
PT J
AU Sutcliffe, JS
Delahanty, RJ
Prasad, HC
McCauley, JL
Han, Q
Jiang, L
Li, C
Folstein, SE
Blakely, RD
AF Sutcliffe, JS
Delahanty, RJ
Prasad, HC
McCauley, JL
Han, Q
Jiang, L
Li, C
Folstein, SE
Blakely, RD
TI Allelic heterogeneity at the serotonin transporter locus (SLC6A4)
confers susceptibility to autism and rigid-compulsive behaviors
SO AMERICAN JOURNAL OF HUMAN GENETICS
LA English
DT Article
ID SINGLE-NUCLEOTIDE POLYMORPHISMS; ACTIVATED PROTEIN-KINASE; GENOMEWIDE
SCREEN; GENOMIC SCREEN; SURFACE EXPRESSION; SEQUENCE VARIANTS; LINKAGE
ANALYSIS; CHROMOSOME 7Q; GENE; DISORDER
AB Autism is a spectrum of neurodevelopmental disorders with a primarily genetic etiology exhibiting deficits in ( 1) development of language and ( 2) social relationships and ( 3) patterns of repetitive, restricted behaviors or interests and resistance to change. Elevated platelet serotonin (5-HT) in 20%-25% of cases and efficacy of selective 5-HT reuptake inhibitors ( SSRIs) in treating anxiety, depression, and repetitive behaviors points to the 5-HT transporter (5-HTT; SERT) as a strong candidate gene. Association studies involving the functional insertion/deletion polymorphism in the promoter (5-HTTLPR) and a polymorphism in intron 2 are inconclusive, possibly because of phenotypic heterogeneity. Nonetheless, mounting evidence for genetic linkage of autism to the chromosome 17q11.2 region that harbors the SERT locus (SLC6A4) supports a genetic effect at or near this gene. We confirm recent reports of sex-biased genetic effects in 17q by showing highly significant linkage driven by families with only affected males. Association with common alleles fails to explain observed linkage; therefore, we hypothesized that preferential transmission of multiple alleles does explain it. From 120 families, most contributing to linkage at 17q11.2, we found four coding substitutions at highly conserved positions and 15 other variants in 5' noncoding and other intronic regions transmitted in families exhibiting increased rigid-compulsive behaviors. In the aggregate, these variants show significant linkage to and association with autism. Our data provide strong support for a collection of multiple, often rare, alleles at SLC6A4 as imposing risk of autism.
C1 Vanderbilt Univ, Dept Mol Physiol & Biophys, Nashville, TN 37232 USA.
Vanderbilt Univ, Ctr Mol Neurosci, Nashville, TN 37232 USA.
Vanderbilt Univ, Ctr Human Genet Res, Nashville, TN 37232 USA.
Vanderbilt Univ, Vanderbilt Kennedy Ctr Res Human Dev, Nashville, TN 37232 USA.
Vanderbilt Univ, Dept Biostat, Nashville, TN 37232 USA.
Vanderbilt Univ, Dept Pharmacol, Nashville, TN 37232 USA.
Johns Hopkins Univ, Sch Med, Dept Psychiat & Behav Sci, Baltimore, MD 21205 USA.
RP Sutcliffe, JS (reprint author), Vanderbilt Univ, Dept Mol Physiol & Biophys, 702 Light Hall, Nashville, TN 37232 USA.
EM james.s.sutcliffe@vanderbilt.edu
RI Li, Chun/B-8388-2012; Sutcliffe, James/C-1348-2012
OI Sutcliffe, James/0000-0001-5200-6007
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NR 74
TC 198
Z9 203
PU UNIV CHICAGO PRESS
PI CHICAGO
PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA
SN 0002-9297
J9 AM J HUM GENET
JI Am. J. Hum. Genet.
PD AUG
PY 2005
VL 77
IS 2
BP 265
EP 279
DI 10.1086/432648
PG 15
WC Genetics & Heredity
SC Genetics & Heredity
GA 943WW
UT WOS:000230387200008
PM 15995945
ER
PT J
AU Posthuma, D
Luciano, M
de Geus, EJC
Wright, MJ
Slagboom, PE
Montgomery, GW
Boomsma, DI
Martin, NG
AF Posthuma, D
Luciano, M
de Geus, EJC
Wright, MJ
Slagboom, PE
Montgomery, GW
Boomsma, DI
Martin, NG
TI A genomewide scan for intelligence identifies quantitative trait loci on
2q and 6p
SO AMERICAN JOURNAL OF HUMAN GENETICS
LA English
DT Article
ID GENERAL COGNITIVE-ABILITY; READING-DISABILITY; CHROMOSOME 6P;
ASSOCIATION ANALYSIS; GENETIC DISSECTION; CANDIDATE GENES; DNA MARKERS;
WIDE SCAN; LINKAGE; AUTISM
AB Between 40% and 80% of the variation in human intelligence ( IQ) is attributable to genetic factors. Except for many rare mutations resulting in severe cognitive dysfunction, attempts to identify these factors have not been successful. We report a genomewide linkage scan involving 634 sibling pairs designed to identify chromosomal regions that explain variation in IQ. Model-free multipoint linkage analysis revealed evidence of a significant quantitative-trait locus for performance IQ at 2q24.1-31.1 (LOD score 4.42), which overlaps the 2q21-33 region that has repeatedly shown linkage to autism. A second region revealed suggestive linkage for both full-scale and verbal IQs on 6p25.3-22.3 ( LOD score 3.20 for full-scale IQ and 2.33 for verbal IQ), overlapping marginally with the 6p22.3-21.31 region implicated in reading disability and dyslexia.
C1 Vrije Univ Amsterdam, Dept Biol Psychol, NL-1081 BT Amsterdam, Netherlands.
Queensland Inst Med Res, Brisbane, Qld 4006, Australia.
Leiden Univ, Med Ctr, Dept Mol Epidemiol, Leiden, Netherlands.
RP Posthuma, D (reprint author), Vrije Univ Amsterdam, Dept Biol Psychol, Boechorstr 1, NL-1081 BT Amsterdam, Netherlands.
EM danielle@psy.vu.nl
RI Luciano, Michelle/F-7277-2010
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NR 50
TC 91
Z9 93
PU UNIV CHICAGO PRESS
PI CHICAGO
PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA
SN 0002-9297
J9 AM J HUM GENET
JI Am. J. Hum. Genet.
PD AUG
PY 2005
VL 77
IS 2
BP 318
EP 326
DI 10.1086/432647
PG 9
WC Genetics & Heredity
SC Genetics & Heredity
GA 943WW
UT WOS:000230387200013
PM 16001363
ER
PT J
AU Martin, I
McDonald, S
AF Martin, I
McDonald, S
TI Evaluating the causes of impaired irony comprehension following
traumatic brain injury
SO APHASIOLOGY
LA English
DT Article
ID CLOSED-HEAD-INJURY; PRAGMATIC LANGUAGE-SKILLS; FRONTAL-LOBE DAMAGE;
STORY COMPREHENSION; LINGUISTIC HUMOR; MIND; COMMUNICATION; CHILDREN;
AUTISM; ABILITY
AB Background: Individuals with traumatic brain injury (TBI) are known to have difficulty in understanding non-literal language devices such as irony. There are at least two possible explanations for poor irony comprehension following TBI; first, deficits might be caused by a specific impairment to theory of mind (ToM) and, second, deficits could be attributed to more general impairment in executive functioning (EF).
Aims: This study aimed to evaluate the role of ToM and EF in the ability to comprehend non-literal ironic jokes.
Methods & Procedures: Participants were 16 individuals who had sustained a TBI and 16 age- and demographic-matched controls. The ability to make inferences about mental states was compared to inferential reasoning capacity more generally. Participants were also assessed on other aspects of EF thought to contribute to inference making (working memory, concept formation, and fluency). The extent to which scores on theses tasks were associated with participants' ability to comprehend ironic jokes was assessed using correlational and regression analyses.
Outcomes & Results: Participants with TBI were significantly impaired on tasks measuring both ToM and EF. ToM was not significantly associated with irony comprehension. Instead, inferential reasoning, more broasdly defined, demonstrated the strongest association. None of the component EF tasks were associated with irony comprehension.
Conclusion: The results of this study do not support the theory that a specific impairment to ToM causes poor irony comprehension in TBI. In contrast, general inferential reasoning was a strong and significant predictor.
C1 Univ New S Wales, Sch Psychol, Sydney, NSW 2052, Australia.
RP McDonald, S (reprint author), Univ New S Wales, Sch Psychol, Sydney, NSW 2052, Australia.
EM s.mcdonald@unsw.edu.au
RI McDonald, Skye/G-4118-2014
OI McDonald, Skye/0000-0003-0723-6094
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NR 66
TC 28
Z9 30
PU PSYCHOLOGY PRESS
PI HOVE
PA 27 CHURCH RD, HOVE BN3 2FA, EAST SUSSEX, ENGLAND
SN 0268-7038
J9 APHASIOLOGY
JI Aphasiology
PD AUG
PY 2005
VL 19
IS 8
BP 712
EP 730
DI 10.1080/0268870305500172203
PG 19
WC Clinical Neurology
SC Neurosciences & Neurology
GA 963NT
UT WOS:000231811700002
ER
PT J
AU Werner, E
Dawson, G
AF Werner, E
Dawson, G
TI Validation of the phenomenon of autistic regression using home
videotapes
SO ARCHIVES OF GENERAL PSYCHIATRY
LA English
DT Article
ID PERVASIVE DEVELOPMENTAL DISORDERS; SPECTRUM DISORDER; EARLY RECOGNITION;
FOLLOW-UP; CHILDREN; AGE; INFANCY; MOVIES; 1ST
AB Context: To date, there has been no objective validation of the phenomenon of autistic regression early in life.
Objective: To validate parental report of autistic regression using behavioral data coded from home videotapes of children with autism spectrum disorder (ASD) vs typical development taken at 12 and 24 months of age.
Design: Home videotapes of 56 children's first and second birthday parties were collected from parents of young children with ASD with and without a reported history of regression and typically developing children. Child behaviors were coded by raters blind to child diagnosis and regression history. A parent interview that elicited information about parents' recall of early symptoms from birth was also administered.
Setting: Participants were recruited from a multidisciplinary study of autism conducted at a major university.
Participants: Fifteen children with ASD with a history of regression, 21 children with ASD with early-onset autism, and 20 typically developing children and their parents participated.
Main Outcome Measures: Observations of children's communicative, social, affective, repetitive behaviors, and toy play coded from videotapes of the toddlers' first and second birthday parties.
Results: Analyses revealed that infants with ASD with regression show similar use of joint attention and more frequent use of words and babble compared with typical infants at 12 months of age. In contrast, infants with, ASD with early onset of symptoms and no regression displayed fewer joint attention and communicative behaviors at 12 months of age. By 24 months of age, both groups of toddlers with ASD displayed fewer instances of word use, vocalizations, declarative pointing, social gaze, and orienting to name as compared with typically developing 24-month-olds. Parent interview data suggested that some children with regression displayed difficulties in regulatory behavior before the regression occurred.
Conclusion: This study validates the existence of early autistic regression.
C1 Univ Washington, Autism Ctr, Seattle, WA 98195 USA.
Univ Washington, Dept Psychol, Seattle, WA 98195 USA.
Univ Washington, Dept Psychiat & Behav Sci, Seattle, WA 98195 USA.
RP Dawson, G (reprint author), Univ Washington, Autism Ctr, Box 357920, Seattle, WA 98195 USA.
EM dawson@uwashington.edu
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NR 24
TC 149
Z9 154
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 515 N STATE ST, CHICAGO, IL 60610 USA
SN 0003-990X
J9 ARCH GEN PSYCHIAT
JI Arch. Gen. Psychiatry
PD AUG
PY 2005
VL 62
IS 8
BP 889
EP 895
DI 10.1001/archpsyc.62.8.889
PG 7
WC Psychiatry
SC Psychiatry
GA 952VX
UT WOS:000231034900010
PM 16061766
ER
PT J
AU Cantor, JM
Klassen, PE
Dickey, R
Christensen, BK
Kuban, ME
Blak, T
Williams, NS
Blanchard, R
AF Cantor, JM
Klassen, PE
Dickey, R
Christensen, BK
Kuban, ME
Blak, T
Williams, NS
Blanchard, R
TI Handedness in pedophilia and hebephilia
SO ARCHIVES OF SEXUAL BEHAVIOR
LA English
DT Article
DE handedness; laterality; neuropsychology; pedophilia; phallometry; sexual
abuse; sex offenders
ID PATHOLOGICAL LEFT-HANDEDNESS; FAMILIAL SINISTRALITY; SEXUAL ORIENTATION;
HOMOSEXUAL MALES; HAND PREFERENCE; INCREASED RISK; BIRTH-ORDER; AGE;
MEN; CHILDREN
AB A sample of 404 adult men underwent assessment following illegal or clinically significant sexual behaviors or interests. Patients' assessments included: administration of a modified version of the Edinburgh Handedness Inventory; recording of patients' phallometric (penile) responses to erotic stimuli depicting adults, pubescent children, and prepubescent children of both sexes; and a tabulation of the numbers of patients' victims, ages 0-11, 12-14, 15-16, and 17 and older, of both sexes. In Study 1, patients' right-handedness scores correlated negatively with their phallometric responses to stimuli depicting prepubescent children and positively with stimuli depicting adults, replicating the pattern described in a previous report (Cantor et al., 2004). Unlike the previous study, however, patients' handedness scores did not significantly correlate with their numbers of prepubescent victims. To explore this discrepancy, Study 2 combined the patients from this replication sample with those in the previously reported sample, categorizing them by the sex and age group of greatest erotic interest to them. The odds of non-right-handedness in men offending predominantly against prepubescent children were approximately two-fold higher than that in men offending predominantly against adults and three-fold higher after eliminating those men with intrafamilial (i.e., incest) offenses. Handedness differences between men erotically interested in males versus females were not statistically significant. These results indicate that the rates of non-right-handedness in pedophilia are much larger than previously suggested and are comparable to the rates observed in pervasive developmental disorders, such as autism, suggesting a neurological component to the development of pedophilia and hebephilia.
C1 Ctr Addict & Mental Hlth, Law & Mental Hlth Program, Toronto, ON M5T 1R8, Canada.
Univ Toronto, Dept Psychiat, Toronto, ON, Canada.
Ctr Addict & Mental Hlth, Schizophrenia Program, Toronto, ON, Canada.
Adler Sch Profess Psychol, Chicago, IL USA.
RP Cantor, JM (reprint author), Ctr Addict & Mental Hlth, Law & Mental Hlth Program, 250 Coll St, Toronto, ON M5T 1R8, Canada.
EM james_cantor@camh.net
RI Cantor, James/P-8796-2014
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NR 47
TC 40
Z9 41
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0004-0002
J9 ARCH SEX BEHAV
JI Arch. Sex. Behav.
PD AUG
PY 2005
VL 34
IS 4
BP 447
EP 459
DI 10.1007/s10508-005-4344-7
PG 13
WC Psychology, Clinical; Social Sciences, Interdisciplinary
SC Psychology; Social Sciences - Other Topics
GA 944WY
UT WOS:000230462800008
PM 16010467
ER
PT J
AU Hollander, E
Anagnostou, E
Chaplin, W
Esposito, K
Haznedar, MM
Licalzi, E
Wasserman, S
Soorya, L
Buchsbaum, M
AF Hollander, E
Anagnostou, E
Chaplin, W
Esposito, K
Haznedar, MM
Licalzi, E
Wasserman, S
Soorya, L
Buchsbaum, M
TI Striatal volume on magnetic resonance imaging and repetitive behaviors
in autism
SO BIOLOGICAL PSYCHIATRY
LA English
DT Article
DE autism; repetitive behaviors; basal ganglia
ID OBSESSIVE-COMPULSIVE DISORDER; BASAL GANGLIA; SPECTRUM DISORDERS;
CHILDHOOD AUTISM; SYDENHAMS CHOREA; DOPAMINE; ADULTS; ADOLESCENTS;
ANTIBODIES; SYMPTOMS
AB Background: The repetitive behaviors seen in autism phenotypically resemble those seen in obsessive-compulsive disorder (OCD) and Tourette Syndrome (TS), disorders in which structural and functional abnormalities of the basal ganglia (BG) are present and correspond to the severity of repetitive behaviors.
Methods: Seventeen subjects with autism by DSM-IV and Autism Diagnostic Interview (ADI) and 17 matched controls completed a 1.5 T magnetic resonance image (MRI) of the brain. Two blinded researchers, with good inter-rater reliability, outlined the tight and left caudate and putamen. Autistic and control BG volumes covaried for total brain volume were compared using analysis of covariance. BG volumes within the autistic group were correlated with the ADI Repetitive Behavior scores (ADI-C domain).
Results: Right caudate volume controlled for total brain volume was significantly larger in autistic subjects than in controls. In addition, fight caudate and total putamen volumes correlated positively with repetitive behavior scores on the ADI-C domain, particularly the higher order OCD-like repetitive behaviors.
Conclusions: Increased right caudate volume in autism is of interest, since this has also been observed in OCD patients. Increased volume of the right caudate and total putamen positively correlated with greater repetitive behaviors, supporting the hypothesis of BG dysfunction associated with repetitive behaviors in autistic adults.
C1 Mt Sinai Sch Med, Dept Psychiat, New York, NY USA.
St Johns Univ, Dept Psychol, New York, NY USA.
RP Hollander, E (reprint author), Mt Sinai Sch Med, Seaver & New York Autism Ctr Excellence, 1 Gustave L Levy Pl,Box 1230,Annenberg Bldt,Suite, New York, NY 10029 USA.
EM Eric.Hollander@mssm.edu
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NR 50
TC 122
Z9 124
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD AUG 1
PY 2005
VL 58
IS 3
BP 226
EP 232
DI 10.1016/j.biopsych.2005.03.040
PG 7
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA 953DR
UT WOS:000231057100007
PM 15939406
ER
PT J
AU Li, H
Yamagata, T
Mori, M
Yasuhara, A
Momoi, MY
AF Li, H
Yamagata, T
Mori, M
Yasuhara, A
Momoi, MY
TI Mutation analysis of methyl-CpG binding protein family genes in autistic
patients
SO BRAIN & DEVELOPMENT
LA English
DT Article
DE autism; methyl-CpG binding protein genes; MECP2; MBD1
ID MECP2; MBD2
AB Methyl-CpG binding protein 2 gene (MECP2), the gene implicated in Rett syndrome, was also reported to be involved in mental retardation and autism. MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a nuclear protein family sharing the methyl-CpG binding domain (MBD) and are related to transcriptional repression. In 65 Japanese autistic patients, all the exons of each gene were screened for mutations by DHPLC, and the results were confirmed by direct sequencing. An R269C mutation that resulted in the addition of cysteine near a cysteine rich region was found in the MBD1 gene in one patient. This mutation was also detected in the patient's father with some phenotypes of autism and his normal sister, but not in 151 controls. Two repeat length polymorphisms, (GGGGCC)2 to 3 and (GGC) 4 to 5, were detected in MBD2, and several polynnorphisms were detected in each gene. Although our findings could not confirm that the genes of this family are responsible for the etiology in the majority of autistic patients, the R269C mutation in the MBD1 gene may relate to autism. The potential association of the high-polymorphic gene variants with autism needs to be studied further. Furthermore, these polymorphisms are useful for linkage analysis. (c) 2004 Published by Elsevier B.V.
C1 Jichi Med Sch, Dept Pediat, Minamimaki, Tochigi 3290498, Japan.
Kansai Med Univ, Kohri Hosp, Dept Pediat, Osaka 5728551, Japan.
RP Momoi, MY (reprint author), Jichi Med Sch, Dept Pediat, 3311-1 Yakushiji, Minamimaki, Tochigi 3290498, Japan.
EM mymomoi@jichi.ac.jp
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NR 11
TC 29
Z9 29
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0387-7604
J9 BRAIN DEV-JPN
JI Brain Dev.
PD AUG
PY 2005
VL 27
IS 5
BP 321
EP 325
DI 10.1016/j.braindev.2004.08.003
PG 5
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SC Neurosciences & Neurology
GA 952JU
UT WOS:000231000600001
PM 15967618
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PT J
AU Ogino, T
Hattori, J
Abiru, K
Nakano, K
Oka, E
Ohtsuka, Y
AF Ogino, T
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Ohtsuka, Y
TI Symptoms related to ADHD observed in patients with pervasive
developmental disorder
SO BRAIN & DEVELOPMENT
LA English
DT Article
DE high-function pervasive developmental disorder; Asperger's disorder;
attention -deficit/hyperactivity disorder; DSM-IV; CBCL
ID ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; DEFICIT HYPERACTIVITY
DISORDER; EXECUTIVE FUNCTION; CHILDREN; AUTISM; MIND; PHARMACOTHERAPY
AB To elucidate attention-deficit/hyperactivity disorder (ADHD)-related factors observed in high-function pervasive developmental disorder (PDD) and their impact on daily life, we classified high-function PDD patients according to the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) criteria for ADHD with the exception of the exclusion criteria (coexistence with PDD), and studied the relationship between ADHD-related aspects and daily behavior problems using the Child Behavior Checklist (CBCL). The subjects were divided into two groups: Group I, eight patients less than 6 years of age; and Group II, eight patients 6 years of age and older. Six patients in Group II met the criteria for ADHD. Five of them were classified as having the predominantly inattentive type of ADHD, and the remaining patient exhibited the combined type. However, no patient in Group I met the criteria for ADHD, suggesting the low sensitivity of the DSM-IV criteria for assessing the inattentiveness of preschoolers. The analyses of the correlation between corresponding items in the DSM-IV criteria and CBCL scores suggested that ADHD-related symptoms in high-function PDD patients have an impact on their daily lives. (c) 2004 Elsevier B.V. All rights reserved.
C1 Okayama Univ, Grad Sch Med & Dent, Dept Child Neurol, Okayama 7008558, Japan.
RP Ogino, T (reprint author), Okayama Univ, Grad Sch Med & Dent, Dept Child Neurol, Shikata Cho 2-5-1, Okayama 7008558, Japan.
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NR 18
TC 13
Z9 16
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0387-7604
J9 BRAIN DEV-JPN
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IS 5
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PG 4
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SC Neurosciences & Neurology
GA 952JU
UT WOS:000231000600005
PM 16023549
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PT J
AU Battaglia, A
AF Battaglia, A
TI The inv dup(15) or idic(15) syndrome: A clinically recognisable
neurogenetic disorder
SO BRAIN & DEVELOPMENT
LA English
DT Review
DE supernumerary marker chromosomes; inv dup(15) syndrome; isodicentric
chromosome 15 syndrome [idic(15)]; autism/autistic-like behaviour;
mental retardation; epilepsy
ID DUP 15; MOLECULAR CHARACTERIZATION; MARKER CHROMOSOMES;
MENTAL-RETARDATION; AUTISTIC DISORDER; PROXIMAL 15Q; DUPLICATION;
INSTABILITY; 15Q11-Q13; DIAGNOSIS
AB The chromosome region 15q11q13 is known for its instability, and many rearrangements may occur in this imprinted segment: deletions associated either with Angelman syndrome (AS) or with Prader-Willi syndrome (PWS), according to parental origin; translocations; inversions; and supernumerary marker chromosomes formed by the inverted duplication of proximal chromosome 15. Inv dup(15) constitute the most common of the heterogeneous group of the extra structurally abnormal chromosomes, and their presence results in tetrasomy 15p and partial tetrasomy 15q. Inv dup(15), containing the Prader-Willi/Angel man syndrome region, are associated with altered behaviour, developmental delay/mental retardation, and seizures/epilepsy. Clinicians should suspect this syndrome in any infant/child with early central hypotonia, minor dysmorphic features, developmental delay, autism or autistic-like behaviour, and who subsequently develops hard to control seizures/epilepsy. Diagnosis is confirmed by standard cytogenetic techniques and FISH analysis. Although, about 100 cases have been reported to date, limited data are available on the natural history. To obtain better information on diagnosis and outcome in a clinical setting, we reviewed the available literature on clinical and behavioural phenotype of inv dup(15) syndrome. (c) 2005 Elsevier B.V. All rights reserved.
C1 Stella Maris Clin Res Inst Child & Adolescent Neu, I-56018 Pisa, Italy.
RP Battaglia, A (reprint author), Stella Maris Clin Res Inst Child & Adolescent Neu, Via Giaicnti 2, I-56018 Pisa, Italy.
EM abattaglia@inpe.unipi.it
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NR 40
TC 51
Z9 54
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0387-7604
J9 BRAIN DEV-JPN
JI Brain Dev.
PD AUG
PY 2005
VL 27
IS 5
BP 365
EP 369
DI 10.1016/j.braindev.2004.08.006
PG 5
WC Clinical Neurology
SC Neurosciences & Neurology
GA 952JU
UT WOS:000231000600010
PM 16023554
ER
PT J
AU Prud'Homme, NH
AF Prud'Homme, NH
TI Autism: the other intelligence. Diagnosis, cognition and support of
autistic people who don't suffer intellectual retardation
SO CANADIAN PSYCHOLOGY-PSYCHOLOGIE CANADIENNE
LA French
DT Book Review
CR PRUDHOMME MH, 2004, AUTISM OTHER INTELLI
NR 1
TC 0
Z9 0
PU CANADIAN PSYCHOL ASSOC
PI OTTAWA
PA 151 SLATER ST, STE 205, OTTAWA, ONTARIO K1P 5H3, CANADA
SN 0708-5591
J9 CAN PSYCHOL
JI Can. Psychol.-Psychol. Can.
PD AUG
PY 2005
VL 46
IS 3
BP 168
EP 170
PG 3
WC Psychology, Multidisciplinary
SC Psychology
GA 003SM
UT WOS:000234701900007
ER
PT J
AU Vojdani, A
Bazargan, M
Vojdani, E
Samadi, J
Nourian, AA
Eghbalieh, N
Cooper, EL
AF Vojdani, A
Bazargan, M
Vojdani, E
Samadi, J
Nourian, AA
Eghbalieh, N
Cooper, EL
TI Heat shock protein and gliadin peptide promote development of peptidase
antibodies in children with autism and patients with autoimmune disease
(vol 11, pg 515, 2004)
SO CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY
LA English
DT Correction
C1 Univ Calif Los Angeles, Lab Comparat Neuroimmunol, Dept Neurobiol, David Geffen Sch Med, Los Angeles, CA 90095 USA.
Immunosci Lab Inc, Sect Neuroimmunol, Beverly Hills, CA 90211 USA.
Charles R Drew Univ Med & Sci, Dept Family Med, Los Angeles, CA 90059 USA.
Univ Calif Berkeley, Neurosci Undergrad Program, Berkeley, CA 94702 USA.
RP Vojdani, A (reprint author), Univ Calif Los Angeles, Lab Comparat Neuroimmunol, Dept Neurobiol, David Geffen Sch Med, Los Angeles, CA 90095 USA.
CR Vojdani A, 2004, CLIN DIAGN LAB IMMUN, V11, P515, DOI 10.1128/CDLI.11.3.515-524.2004
NR 1
TC 0
Z9 0
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 1071-412X
J9 CLIN DIAGN LAB IMMUN
JI Clin. Diagn. Lab. Immunol.
PD AUG
PY 2005
VL 12
IS 8
BP 1011
EP 1011
DI 10.1128/CDLI.12.8.1011.2005
PG 1
WC Immunology; Infectious Diseases; Microbiology
SC Immunology; Infectious Diseases; Microbiology
GA 955VU
UT WOS:000231256500019
ER
PT J
AU Simsek, M
Al-Sharbati, M
Al-Adawi, S
Ganguly, SS
Lawatia, K
AF Simsek, M
Al-Sharbati, M
Al-Adawi, S
Ganguly, SS
Lawatia, K
TI Association of the risk allele of dopamine transporter gene (DAT1*10) in
Omani male children with attention-deficit hyperactivity disorder
SO CLINICAL BIOCHEMISTRY
LA English
DT Article
DE VNTR; polymorphism; dopamine transporter gene; DAT1; attention-deficit
hyperactivity disorder; ADHD
ID 3' VNTR POLYMORPHISM; DEFICIT/HYPERACTIVITY DISORDER; ADHD; LINKAGE;
AUTISM; REGION; DAT1; SCAN
AB Objectives: To determine the frequency of the VNTR alleles in the human dopamine transporter gene (DAT1) in the Omani population and to investigate association of the VNTR alleles with attention-deficit hyperactivity disorder (ADHD).
Design and methods: 92 Omani children with ADHD and 110 healthy Omani subjects were genotyped for the DAT1-VNTR polymorphism in a case-control study using two independent PCR tests (one developed in our laboratory) followed by agarose gel electrophoresis.
Results and conclusions: We determined the DAT1-VNTR alleles in 202 Omani subjects. There were two common alleles (DAT1*9 and *10) and five rare ones. The DAT1*10 allele distribution was essentially the same both in the control (60.9%) and the patient group (64.6%). There was, however, a relatively higher occurrence of the DAT1*10 allele in ADHD males (69.4%) than females (55%), but this gender difference was not present in the control group (males 60%, females 62%). (C) 2005 The Canadian Society of Clinical Chemists. All rights reserved.
C1 Sultan Qaboos Univ, Coll Med, Dept Biochem, Muscat 123, Oman.
Sultan Qaboos Univ, Coll Med, Dept Behav Sci, Muscat 123, Oman.
Sultan Qaboos Univ, Coll Med, Dept Epidemiol & Stat, Muscat 123, Oman.
RP Simsek, M (reprint author), Sultan Qaboos Univ, Coll Med, Dept Biochem, POB 35, Muscat 123, Oman.
EM mssimsek@omantel.net.om
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NR 20
TC 11
Z9 13
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0009-9120
J9 CLIN BIOCHEM
JI Clin. Biochem.
PD AUG
PY 2005
VL 38
IS 8
BP 739
EP 742
DI 10.1016/j.clinbiochem.2005.04.016
PG 4
WC Medical Laboratory Technology
SC Medical Laboratory Technology
GA 952HT
UT WOS:000230995300011
PM 15993876
ER
PT J
AU Preissler, MA
Carey, S
AF Preissler, MA
Carey, S
TI The role of inferences about referential intent in word learning:
Evidence from autism
SO COGNITION
LA English
DT Article
DE autism; word learning; toddlers
ID INFANTS ABILITY; CHILDREN; ACQUISITION; LANGUAGE; STRATEGY; ACTS
AB Young children are readily able to use known labels to constrain hypotheses about the meanings of new words under conditions of referential ambiguity. At issue is the kind of information children use to constrain such hypotheses. According to one theory, children take into account the speaker's intention when solving a referential puzzle. In the present studies, children with autism were impaired in monitoring referential intent, but were equally successful as normally developing 24-month-old toddlers at mapping novel words to unnamed items under conditions of referential ambiguity. Therefore, constraints that lead the child to map a novel label to a previously unnamed object under these circumstances are not solely based on assessments of speakers' intentions. (c) 2005 Elsevier B.V. All rights reserved.
C1 Yale Univ, Dept Psychol, New Haven, CT 06520 USA.
RP Preissler, MA (reprint author), Yale Univ, Dept Psychol, 2 Hillhouse Ave, New Haven, CT 06520 USA.
EM melissa.preissler@yale.edu
RI Allen, Melissa/F-9711-2011
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NR 38
TC 41
Z9 42
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0010-0277
J9 COGNITION
JI Cognition
PD AUG
PY 2005
VL 97
IS 1
BP B13
EP B23
DI 10.1016/j.cognition.2005.01.008
PG 11
WC Psychology, Experimental
SC Psychology
GA 966DI
UT WOS:000231999400009
PM 15925356
ER
PT J
AU Ristic, J
Mottron, L
Friesen, CK
Iarocci, G
Burack, JA
Kingstone, A
AF Ristic, J
Mottron, L
Friesen, CK
Iarocci, G
Burack, JA
Kingstone, A
TI Eyes are special but not for everyone: The case of autism
SO COGNITIVE BRAIN RESEARCH
LA English
DT Article
DE eye direction; social attenuation; autism
ID SOCIAL ATTENTION; GAZE; PERCEPTION; INDIVIDUALS; CHILDREN; ARROW; CUES
AB Current research indicates that human gaze direction is a special cue for shifting attention for one of two reasons: (1) it reflects social desires and intentions and (2) its basic perceptual features usually correspond to important events in the environment. This study, conducted with individuals with autism and with age- and IQ-matched typically developing individuals, dissociates these two often-confounded explanations and demonstrates that eyes appear to be special for typically developing individuals because of their social power, whereas gaze effects are mediated by feature correspondence among persons with autism. (c) 2005 Elsevier B.V. All rights reserved.
C1 Univ British Columbia, Dept Psychol, Vancouver, BC V6T 1Z4, Canada.
Univ Montreal, Hop Riviere des Prairies, Montreal, PQ H3C 3J7, Canada.
N Dakota State Univ, Fargo, ND 58105 USA.
Simon Fraser Univ, Burnaby, BC V5A 1S6, Canada.
McGill Univ, Hop Riviere des Prairies, Montreal, PQ H3A 2T5, Canada.
RP Ristic, J (reprint author), Univ British Columbia, Dept Psychol, 2136 W Mall, Vancouver, BC V6T 1Z4, Canada.
EM jelena.ristic@telus.net
CR Allison T, 2000, TRENDS COGN SCI, V4, P267, DOI 10.1016/S1364-6613(00)01501-1
Baron-Cohen Simon, 1995, MINDBLINDNESS ESSAY
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Swettenham J, 2003, PHILOS T R SOC B, V358, P325, DOI 10.1098/rstb.2002.1203
NR 19
TC 96
Z9 99
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0926-6410
J9 COGNITIVE BRAIN RES
JI Cognit. Brain Res.
PD AUG
PY 2005
VL 24
IS 3
BP 715
EP 718
DI 10.1016/j.cogbrainres.2005.02.007
PG 4
WC Computer Science, Artificial Intelligence; Neurosciences; Neuroimaging
SC Computer Science; Neurosciences & Neurology
GA 962PH
UT WOS:000231744200031
ER
PT J
AU Lee, JH
Lee, HJ
Lee, YS
Cheong, SS
Park, KB
AF Lee, JH
Lee, HJ
Lee, YS
Cheong, SS
Park, KB
TI Application of a virtual reality-tangible interaction system in sensory
integration training and assessment for children with autism
SO CYBERPSYCHOLOGY & BEHAVIOR
LA English
DT Meeting Abstract
C1 Hanyang Univ, Coll Med, Dept Biomed Engn, Seoul 133791, South Korea.
EM clipsy@unitel.co.kr
CR AYRES AJ, 1972, J LEARN DISABIL, V5, P338
Parsons S, 2002, J INTELL DISABIL RES, V46, P430, DOI 10.1046/j.1365-2788.2002.00425.x
NR 2
TC 0
Z9 0
PU MARY ANN LIEBERT INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1094-9313
J9 CYBERPSYCHOL BEHAV
JI CyberPsychol. Behav.
PD AUG
PY 2005
VL 8
IS 4
BP 339
EP 339
PG 1
WC Communication; Psychology, Applied
SC Communication; Psychology
GA 956KH
UT WOS:000231298100064
ER
PT J
AU Rasalam, AD
Hailey, H
Williams, JHG
Moore, SJ
Turnpenny, PD
Lloyd, DJ
Dean, JCS
AF Rasalam, AD
Hailey, H
Williams, JHG
Moore, SJ
Turnpenny, PD
Lloyd, DJ
Dean, JCS
TI Characteristics of fetal anticonvulsant syndrome associated autistic
disorder
SO DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY
LA English
DT Article
ID VALPROATE SYNDROME; ANTIEPILEPTIC DRUGS; CONGENITAL-MALFORMATIONS;
ADDITIONAL EVIDENCE; CHILDREN; EPILEPSY; MOTHERS; RISK; ACID
AB The aim of this study was to evaluate the clinical features and frequency of autistic disorder or Asperger syndrome (AS; according to Diagnostic and Statistical Manual of Mental Disorders, 4th edition [DSM-IV] criteria) in children exposed to anticonvulsant medication in utero. During a 20-year study period, 626 children were born in Aberdeen to mothers taking antiepileptic drugs (AEDs). The study examined long-term effects of prenatal exposure to AEDs in 260 children (122 males, 138 females). Of these, 26 (16 males) were reported by parents to have social or behavioural difficulties. Eleven children (6 males, 5 females) fulfilled the DSM-IV criteria for autistic disorder and one (female) fulfilled the DSM-IV criteria for AS. These children comprised 4.6% of the exposed children studied, and 1.9% of all exposed children born during the study period. Mean age of these children at diagnosis was 5 years 4 months (SD 2y 11mo) and 9 years 10 months (SD 3y 10mo) at the time of this study. Other children from the group of 26 had difficulties in areas of speech and language development and social communication but did not meet the criteria for an autism spectrum disorder (ASD). Sodium valproate was the drug most commonly associated with autistic disorder, five of 56 (8.9%) of the study children exposed to sodium valproate alone had either autistic disorder or AS. It was concluded that prenatal exposure to anticonvulsant medication is a risk factor for the development of an ASD. Fetal anticonvulsant syndrome associated autistic disorder is characterized by an even sex ratio, absence of regression or skill loss, and language delay in the absence of global delay.
C1 Univ Aberdeen, Dept Child Hlth, Aberdeen AB25 2ZH, Scotland.
Aberdeen Royal Infirm, Dept Med Genet, Aberdeen, Scotland.
Mem Univ Newfoundland, Med Genet Program, St John, NF, Canada.
Royal Devon & Exeter Hosp, Clin Genet Serv, Exeter EX2 5DW, Devon, England.
Royal Aberdeen Childrens Hosp, Dept Neonatal Med, Aberdeen, Scotland.
RP Rasalam, AD (reprint author), Univ Aberdeen, Royal Aberdeen Childrens Hosp, Dept Child Hlth, Aberdeen AB25 2ZH, Scotland.
EM adrasalam@nhs.net
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NR 22
TC 130
Z9 133
PU CAMBRIDGE UNIV PRESS
PI NEW YORK
PA 40 WEST 20TH ST, NEW YORK, NY 10011-4211 USA
SN 0012-1622
J9 DEV MED CHILD NEUROL
JI Dev. Med. Child Neurol.
PD AUG
PY 2005
VL 47
IS 8
BP 551
EP 555
DI 10.1017/S0012162205001076
PG 5
WC Clinical Neurology; Pediatrics
SC Neurosciences & Neurology; Pediatrics
GA 952NV
UT WOS:000231012200012
PM 16108456
ER
PT J
AU Ochs, E
Solomon, O
Sterponi, L
AF Ochs, E
Solomon, O
Sterponi, L
TI Limitations and transformations of habitus in Child-Directed
Communication
SO DISCOURSE STUDIES
LA English
DT Article; Proceedings Paper
CT 10th Annual Conferece on Language, Interaction and Culture
CY MAY, 2004
CL Los Angeles, CA
HO Unic California Los Angeles
DE autism; Child-Directed Communication; habitus; language socialization
ID AUTISM SPECTRUM DISORDER; BABY TALK; LANGUAGE SOCIALIZATION; CULTURAL
VARIATION; HOME VIDEOTAPES; INFANTS; MOTHERS; GAZE; AGE; DISENGAGEMENT
AB This article offers an alternative approach to paradigms that cast culture solely as a nurturing influence on children's language development. It proposes a dimensional model of Child-Directed Communication (CDC) to delineate ways in which a community's habitus may impede the communicative potential of children with neuro-developmental conditions such as severe autism. It argues that certain features of Euro-American CDC are ill-adapted for autistic children. Due to inertia, caregivers often find themselves unable to transcend the limitations of CDC habitus. Yet, occasionally, a transformation in CDC emerges that more effectively engages children with impairments. The article analyzes one such transformation forged in the niche of a unique mother-son relationship in India and then introduced in the USA.
C1 Univ Calif Los Angeles, Dept Anthropol, Los Angeles, CA 90095 USA.
Univ Calif Berkeley, Grad Sch Educ, Berkeley, CA 94720 USA.
RP Ochs, E (reprint author), Univ Calif Los Angeles, Dept Anthropol, 341 Haines Hall, Los Angeles, CA 90095 USA.
EM eochs@anthro.ucla.edu; solomono@ucla.edu; sterponi@berkeley.edu
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NR 148
TC 24
Z9 24
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1461-4456
EI 1461-7080
J9 DISCOURSE STUD
JI Discourse Stud.
PD AUG-OCT
PY 2005
VL 7
IS 4-5
BP 547
EP 583
DI 10.1177/1461445605054406
PG 37
WC Communication
SC Communication
GA 976LS
UT WOS:000232735600008
ER
PT J
AU Burbacher, TM
Shen, DD
Liberato, N
Grant, KS
Cernichiari, E
Clarkson, T
AF Burbacher, TM
Shen, DD
Liberato, N
Grant, KS
Cernichiari, E
Clarkson, T
TI Comparison of blood and brain mercury levels in infant monkeys exposed
to methylmercury or vaccines containing thimerosal
SO ENVIRONMENTAL HEALTH PERSPECTIVES
LA English
DT Article
DE brain and blood distribution; elimination half-life; ethylmercury;
infant nonhuman primates; methylmercury; thimerosal
ID MACACA-FASCICULARIS INFANTS; VISUAL RECOGNITION MEMORY; METHYL MERCURY;
ATOMIC-ABSORPTION; THIOMERSAL; NEUROTOXICITY; MACAQUES; NUMBER; AUTISM;
CORTEX
AB Thimerosal is a preservative that has been used in manufacturing vaccines since the 1930s. Reports have indicated that infants can receive ethylmercury (in the form of thimerosal) at or above the U.S. Environmental Protection Agency guidelines for methylmercury exposure, depending on the exact vaccinations, schedule, and size of the infant. In this study we compared the systemic disposition and brain distribution of total and inorganic mercury in infant monkeys after thimerosal exposure with those exposed to MeHg. Monkeys were exposed to MeHg (via oral gavage) or vaccines containing thimerosal (via intramuscular injection) at birth and 1, 2, and 3 weeks of age. Total blood Hg levels were determined 2, 4, and 7 days after each exposure. Total and inorganic brain Hg levels were assessed 2, 4, 7, or 28 days after the last exposure. The initial and terminal half-life of Hg in blood after thimerosal exposure was 2.1 and 8.6 days, respectively, which are significantly shorter than the elimination half-life of Hg after MeHg exposure at 21.5 days. Brain concentrations of total Hg were significantly lower by approximately 3-fold for the thimerosal-exposed monkeys when compared with the MeHg infants, whereas the average brain-to-blood concentration ratio was slightly higher for the thimerosal-exposed monkeys (3.5 +/- 0.5 vs. 2.5 +/- 0.3). A higher percentage of the total Hg in the brain was in the form of inorganic Hg for the thimerosal-exposed monkeys (34% vs. 7%). The results indicate that MeHg is not a suitable reference for risk assessment from exposure to thimerosal-derived Hg. Knowledge of the toxicokinetics and developmental toxicity of thimerosal is needed to afford a meaningful assessment of the developmental effects of thimerosal-containing vaccines.
C1 Univ Washington, Sch Publ Hlth & Community Med, Dept Environm & Occupat Hlth Sci, Seattle, WA 98195 USA.
Univ Washington, Washington Natl Primate Res Ctr, Seattle, WA 98195 USA.
Univ Washington, Ctr Human Dev & Disabil, Seattle, WA 98195 USA.
Univ Washington, Dept Pharm, Sch Pharm, Seattle, WA 98195 USA.
Univ Washington, Dept Pharmaceut, Sch Pharm, Seattle, WA 98195 USA.
Univ Rochester, Sch Med, Dept Environm Med, Rochester, NY USA.
RP Burbacher, TM (reprint author), Univ Washington, Sch Publ Hlth & Community Med, Dept Environm & Occupat Hlth Sci, 1705 NE Pacific St,Hlth Sci Bldg F555, Seattle, WA 98195 USA.
EM tmb@u.washington.edu
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NR 39
TC 120
Z9 126
PU US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE
PI RES TRIANGLE PK
PA NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, PO BOX 12233,
RES TRIANGLE PK, NC 27709-2233 USA
SN 0091-6765
J9 ENVIRON HEALTH PERSP
JI Environ. Health Perspect.
PD AUG
PY 2005
VL 113
IS 8
BP 1015
EP 1021
DI 10.1289/ehp.7712
PG 7
WC Environmental Sciences; Public, Environmental & Occupational Health;
Toxicology
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health; Toxicology
GA 951OV
UT WOS:000230941100039
PM 16079072
ER
PT J
AU Kraemer, B
Delsignore, A
Gundelfinger, R
Schnyder, U
Hepp, U
AF Kraemer, B
Delsignore, A
Gundelfinger, R
Schnyder, U
Hepp, U
TI Comorbidity of Asperger syndrome and gender identity disorder
SO EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
LA English
DT Article
DE Asperger syndrome; autistic disorder; gender identity; transsexualism;
comorbidity
ID HIGH-FUNCTIONING AUTISM; ADULTS; CHILDREN
AB The case of a 35-yearold biological woman with Asperger syndrome (AS) and gender identity disorder (GID) fulfilling DSM-IV criteria is reported. Against the background of recently emerging theories of cognitive male pattern underlying autism we present additional psychological assessments in order to discuss any possible interaction or discrimination between AS and GID. Whilst we explain GID as a secondary feature of AS, we examine the assumption of the necessity of treating GID in AS as a primary GID in accordance with international standards. We consider the treatment of GID as compelling, particularly because curative therapy for AS is lacking and with GID treatment in this vein, the patient gains psychosocial improvement.
C1 Univ Zurich Hosp, Dept Psychiat, CH-8091 Zurich, Switzerland.
Zentrum Kinder & Jugendpsychiat, CH-8032 Zurich, Switzerland.
RP Kraemer, B (reprint author), Univ Zurich Hosp, Dept Psychiat, Culmannstr 8, CH-8091 Zurich, Switzerland.
EM bernd.kraemer@usz.ch
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NR 21
TC 18
Z9 19
PU DR DIETRICH STEINKOPFF VERLAG
PI DARMSTADT
PA PO BOX 10 04 62, D-64204 DARMSTADT, GERMANY
SN 1018-8827
J9 EUR CHILD ADOLES PSY
JI Eur. Child Adolesc. Psych.
PD AUG
PY 2005
VL 14
IS 5
BP 292
EP 296
DI 10.1007/s00787-005-0469-4
PG 5
WC Psychology, Developmental; Pediatrics; Psychiatry
SC Psychology; Pediatrics; Psychiatry
GA 940AI
UT WOS:000230115700007
PM 15981142
ER
PT J
AU Jass, JR
AF Jass, JR
TI The intestinal lesion of autistic spectrum disorder
SO EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
LA English
DT Article
DE autism; inflammation; intestine
ID LYMPHONODULAR HYPERPLASIA; CHILDREN; CHILDHOOD
AB This editorial briefly reviews the significance of lymphoid nodular hyperplasia in the intestinal tract of children with autistic spectrum disorder. The distinction between physiological and pathological lymphoid hyperplasia of the intestinal tract is of importance in the context of a possible causative link with autism. A primary intestinal lesion may occur as part of the broad spectrum of immunological disorders to which autistic children are prone. This could result in increased intestinal permeability to peptides of dietary origin which may then lead to disruption of neuroregulatory mechanisms required for normal brain development Alternatively, there could be a primary defect in the translocation and processing of factors derived from the intestinal lumen. These possibilities deserve further investigation and should not be lost in the fog of the controversy regarding the role of measles/mumps/rubella vaccination in the aetiology of autistic spectrum disorder.
C1 McGill Univ, Dept Pathol, Montreal, PQ H3A 2B4, Canada.
RP Jass, JR (reprint author), McGill Univ, Dept Pathol, Montreal, PQ H3A 2B4, Canada.
EM jeremy.jass@mcgill.ca
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NR 14
TC 9
Z9 10
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0954-691X
J9 EUR J GASTROEN HEPAT
JI Eur. J. Gastroenterol. Hepatol.
PD AUG
PY 2005
VL 17
IS 8
BP 821
EP 822
DI 10.1097/00042737-200508000-00007
PG 2
WC Gastroenterology & Hepatology
SC Gastroenterology & Hepatology
GA 957RX
UT WOS:000231392100007
PM 16003130
ER
PT J
AU Borg, I
Freude, K
Kubart, SK
Hoffmann, K
Menzel, C
Laccone, F
Firth, H
Ferguson-Smith, MA
Tommerup, N
Ropers, HH
Sargan, D
Kalscheuer, VM
AF Borg, I
Freude, K
Kubart, SK
Hoffmann, K
Menzel, C
Laccone, F
Firth, H
Ferguson-Smith, MA
Tommerup, N
Ropers, HH
Sargan, D
Kalscheuer, VM
TI Disruption of Netrin G1 by a balanced chromosome translocation in a girl
with Rett syndrome
SO EUROPEAN JOURNAL OF HUMAN GENETICS
LA English
DT Article
DE Rett syndrome; Netrin G1; balanced chromosome rearrangement
ID MENTAL-RETARDATION; INFANTILE SPASMS; MUTATIONS; GENE; CDKL5/STK9;
OUTGROWTH; DISEASE; AUTISM; MECP2
AB We have identified a girl with characteristic features of Rett syndrome ( RTT) who carries a de novo balanced translocation involving chromosomes 1 and 7. Both breakpoints were mapped by fluorescence in situ hybridization with selected genomic clones from the regions of interest. Southern blot hybridisations, utilizing probes derived from breakpoint spanning BACs, detected several aberrant fragments specific for the patient. Sequence analysis of the cloned junction fragment indicated that on chromosome 1 the predominantly brain-expressed Netrin G1 ( NTNG1) gene is disrupted, whereas on chromosome 7 there was no indication for a truncated gene. The chromosome 1 breakpoint lies within the 30 part of NTNG1 and affects alternatively spliced transcripts, suggesting that the phenotype in this patient is the result of disturbed NTNG1 expression. In silico translation of the NTNG1 splice variants predicted protein isoforms with different C-termini: one membrane bound through a glycosylphosphatidylinositol anchor and the other soluble. The membrane-bound protein isoform would be affected by the breakpoint, whereas the soluble form would remain intact. Our results suggest that the central nervous system is sensitive to NTNG1 expression levels and that NTNG1 is a novel candidate disease gene for RTT.
C1 Max Planck Inst Mol Genet, D-14195 Berlin, Germany.
Univ Cambridge, Ctr Vet & Biomed Sci, Dept Vet Med, Cambridge, England.
Univ Cambridge, Addenbrookes Hosp, Dept Med Genet, Cambridge CB2 2QQ, England.
Inst Human Genet, Gottingen, Germany.
Univ Copenhagen, IMBG, Wilhelm Johannsen Ctr Funct Genome Res, Dept Med Biochem & Genet, Copenhagen, Denmark.
RP Kalscheuer, VM (reprint author), Max Planck Inst Mol Genet, Ihnestr 73, D-14195 Berlin, Germany.
EM kalscheu@molgen.mpg.de
CR Amir RE, 1999, NAT GENET, V23, P185
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NR 16
TC 48
Z9 49
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1018-4813
J9 EUR J HUM GENET
JI Eur. J. Hum. Genet.
PD AUG
PY 2005
VL 13
IS 8
BP 921
EP 927
DI 10.1038/sj.ejhg.5201429
PG 7
WC Biochemistry & Molecular Biology; Genetics & Heredity
SC Biochemistry & Molecular Biology; Genetics & Heredity
GA 949BR
UT WOS:000230760400006
PM 15870826
ER
PT J
AU Jansson-Verkasalo, E
Kujala, T
Jussila, K
Mattila, ML
Moilanen, I
Naatanen, R
Suominen, K
Korpilahti, P
AF Jansson-Verkasalo, E
Kujala, T
Jussila, K
Mattila, ML
Moilanen, I
Naatanen, R
Suominen, K
Korpilahti, P
TI Similarities in the phenotype of the auditory neural substrate in
children with Asperger syndrome and their parents
SO EUROPEAN JOURNAL OF NEUROSCIENCE
LA English
DT Article
DE Asperger syndrome; auditory perception; autistic spectrum; gender;
mismatch negativity
ID EVENT-RELATED POTENTIALS; HIGH-FUNCTIONING AUTISM; MISMATCH NEGATIVITY;
EVOKED-POTENTIALS; SPEECH; INDIVIDUALS; BRAIN; PERCEPTION; DISORDERS;
SPECTRUM
AB Asperger syndrome (AS) is a developmental disorder of brain function characterized by deficits in social interaction including difficulties in understanding emotional expressions. Children with AS share some of the behavioural characteristics with their parents and AS seems to run particularly in the male members of the same families. The aim of the present study was to determine whether similarities could be found between children with AS and their parents at central auditory processing. It was found that in children with AS the sound encoding, as reflected by the exogenous components of event-related potentials, was similarly abnormal as in both their mothers and fathers. However, their abnormal cortical auditory discrimination, as indexed by the prolonged latency of the mismatch negativity, resembled that of their fathers but not that of their mothers. The present results suggest that complex genetic mechanisms may contribute to auditory abnormalities encountered in children with AS.
C1 Univ Helsinki, Dept Psychol, Cognit Brain Res Unit, Helsinki 00014, Finland.
Oulu Univ, Cognit Lab, Oulu, Finland.
Univ Helsinki, Helsinki Collegium Adv Studies, FIN-00014 Helsinki, Finland.
Univ Helsinki, Helsinki Brain Res Ctr, FIN-00014 Helsinki, Finland.
Oulu Univ Hosp, Dept Child Psychiat, Oulu, Finland.
Univ Oulu, Dept Finnish Informat Studies & Logoped, Oulu, Finland.
RP Jansson-Verkasalo, E (reprint author), Univ Helsinki, Dept Psychol, Cognit Brain Res Unit, POB 8, Helsinki 00014, Finland.
EM eira.jansson-verkasalo@helsinki.fi
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NR 36
TC 21
Z9 21
PU BLACKWELL PUBLISHING
PI OXFORD
PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND
SN 0953-816X
J9 EUR J NEUROSCI
JI Eur. J. Neurosci.
PD AUG
PY 2005
VL 22
IS 4
BP 986
EP 990
DI 10.1111/j.1460-9568.2005.04216.x
PG 5
WC Neurosciences
SC Neurosciences & Neurology
GA 957UB
UT WOS:000231397700020
PM 16115221
ER
PT J
AU Bear, MF
AF Bear, MF
TI Therapeutic implications of the mGluR theory of fragile X mental
retardation
SO GENES BRAIN AND BEHAVIOR
LA English
DT Review
DE anxiety disorder; autism; cognitive development; dendritic protein
synthesis; long-term depression; metabotropic glutamate receptors;
seizure disorder
ID METABOTROPIC GLUTAMATE RECEPTORS; LONG-TERM DEPRESSION;
OBSESSIVE-COMPULSIVE DISORDER; STRIATAL SYNAPTIC PLASTICITY; CEREBELLAR
PURKINJE-CELLS; PROTEIN-SYNTHESIS; EPILEPTIFORM DISCHARGES; LATERAL
AMYGDALA; DENDRITIC SPINES; FEAR MEMORY
AB Evidence is reviewed that the consequences of group 1 metabotropic glutamate receptor (Gp1 mGluR) activation are exaggerated in the absence of the fragile X mental retardation protein, likely reflecting altered dendritic protein synthesis. Abnormal mGluR signaling could be responsible for remarkably diverse psychiatric and neurological symptoms in fragile X syndrome, including delayed cognitive development, seizures, anxiety, movement disorders and obesity.
C1 MIT, Picower Ctr Learning & Memory, Howard Hughes Med Inst, Cambridge, MA 02139 USA.
MIT, Dept Brain & Cognit Sci, Cambridge, MA 02139 USA.
RP Bear, MF (reprint author), MIT, Picower Ctr Learning & Memory, Howard Hughes Med Inst, 77 Massachusetts Ave, Cambridge, MA 02139 USA.
EM mbear@mit.edu
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NR 60
TC 90
Z9 92
PU BLACKWELL PUBLISHING
PI OXFORD
PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND
SN 1601-1848
J9 GENES BRAIN BEHAV
JI Genes Brain Behav.
PD AUG
PY 2005
VL 4
IS 6
BP 393
EP 398
DI 10.1111/j.1601-183X.2005.00135.x
PG 6
WC Behavioral Sciences; Neurosciences
SC Behavioral Sciences; Neurosciences & Neurology
GA 959CI
UT WOS:000231494100006
PM 16098137
ER
PT J
AU Kwasnicka-Crawford, DA
Carson, AR
Roberts, W
Summers, AM
Rehnstrom, K
Jarvela, I
Scherer, SW
AF Kwasnicka-Crawford, DA
Carson, AR
Roberts, W
Summers, AM
Rehnstrom, K
Jarvela, I
Scherer, SW
TI Characterization of a novel cation transporter ATPase gene (ATP13A4)
interrupted by 3q25-q29 inversion in an individual with language delay
SO GENOMICS
LA English
DT Article
DE specific language impairment (SLI); P-type ATPase; paracentric inversion
ID P-TYPE ATPASES; MAJOR SUSCEPTIBILITY LOCUS; AUTISM-SPECTRUM DISORDERS;
BRAIN ABNORMALITIES; ASSOCIATION CORTEX; CHROMOSOME 3Q25-27; SEVERE
SPEECH; IMPAIRMENT; LOCALIZATION; ASYMMETRY
AB Specific language impairment (SLI) is defined as failure to acquire normal language skills despite adequate intelligence and environmental stimulation. Although SLI disorders are often heritable, the genetic basis is likely to involve a number of risk factors. This study describes a 7-year-old girl carrying an inherited paracentric inversion of the long arm of chromosome 3 [46XX, inv(3)(q25.32-q29)] having clinically defined expressive and receptive language delay. Fluorescence in situ hybridization (FISH) with locus-specific bacterial artificial chromosome clones (BACs) as probes was used to characterize the inverted chromosome 3. The proximal and distal inversion breakpoint was found to reside between markers D3S3692/D3S1553 and D3S3590/D3S2305, respectively. ATP13A4, a novel gene coding for a cation-tran sporting P-type ATPase, was found to be disrupted by the distal breakpoint. The ATP13A4 gene was shown to comprise a 3591-bp transcript encompassing 30 exons spanning 152 kb of the genomic DNA. This study discusses the characterization of ATP13A4 and its possible involvement in speech-language disorder. (c) 2005 Elsevier Inc. All rights reserved.
C1 Hosp Sick Children, Dept Genet & Genom Biol, Toronto, ON M5G 1X8, Canada.
Child Dev Ctr, Dept Pediat, Toronto, ON, Canada.
N York Gen Hosp, Dept Genet, Toronto, ON, Canada.
Univ Toronto, Dept Mol & Med Genet, Toronto, ON, Canada.
Natl Publ Hlth Inst, Dept Mol Med, Helsinki, Finland.
Univ Helsinki, Dept Med Genet, Helsinki, Finland.
Univ Helsinki, Cent Hosp, Genet Mol Lab, Helsinki, Finland.
RP Scherer, SW (reprint author), Hosp Sick Children, Dept Genet & Genom Biol, 555 Univ Ave,Room 10-133A, Toronto, ON M5G 1X8, Canada.
EM steve@genet.sickkids.on.ca
RI Howe, Jennifer/I-9013-2012; Scherer, Stephen /B-3785-2013; Jarvela,
Irma/L-5836-2013
OI Scherer, Stephen /0000-0002-8326-1999;
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NR 40
TC 27
Z9 28
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0888-7543
J9 GENOMICS
JI Genomics
PD AUG
PY 2005
VL 86
IS 2
BP 182
EP 194
DI 10.1016/j.ygeno.2005.04.002
PG 13
WC Biotechnology & Applied Microbiology; Genetics & Heredity
SC Biotechnology & Applied Microbiology; Genetics & Heredity
GA 947QU
UT WOS:000230662000006
PM 15925480
ER
PT J
AU Nuber, UA
Kriaucionis, S
Roloff, TC
Guy, J
Selfridge, J
Steinhoff, C
Schulz, R
Lipkowitz, B
Ropers, HH
Holmes, MC
Bird, A
AF Nuber, UA
Kriaucionis, S
Roloff, TC
Guy, J
Selfridge, J
Steinhoff, C
Schulz, R
Lipkowitz, B
Ropers, HH
Holmes, MC
Bird, A
TI Up-regulation of glucocorticoid-regulated genes in a mouse model of Rett
syndrome
SO HUMAN MOLECULAR GENETICS
LA English
DT Article
ID CPG-BINDING PROTEIN-2; NEURONAL MATURATION; MECP2; EXPRESSION;
CHROMATIN; MICE; TRANSCRIPTION; DEFICIENCY; OSTEOPENIA; AUTISM
AB Rett syndrome (RTT) is a severe form of mental retardation, which is caused by spontaneous mutations in the X-linked gene MECP2. How the loss of MeCP2 function leads to RTT is currently unknown. Mice lacking the Mecp2 gene initially show normal postnatal development but later acquire neurological phenotypes, including heightened anxiety, that resemble RTT. The MECP2 gene encodes a methyl-CpG-binding protein that can act as a transcriptional repressor. Using cDNA microarrays, we found that Mecp2-null animals differentially express several genes that are induced during the stress response by glucocorticoids. Increased levels of mRNAs for serum glucocorticoid-inducible kinase 1 (Sgk) and FK506-binding protein 51 (Fkbp5) were observed before and after onset of neurological symptoms, but plasma glucocorticoid was not significantly elevated in Mecp2-null mice. MeCP2 is bound to the Fkbp5 and Sgk genes in brain and may function as a modulator of glucocorticoid-inducible gene expression. Given the known deleterious effect of glucocorticoid exposure on brain development, our data raise the possibility that disruption of MeCP2-dependent regulation of stress-responsive genes contributes to the symptoms of RTT.
C1 Univ Edinburgh, Wellcome Trust Ctr Cell Biol, Edinburgh EH9 3JR, Midlothian, Scotland.
Max Planck Inst Mol Genet, D-14195 Berlin, Germany.
Univ Edinburgh, Western Gen Hosp, Dept Clin Neurosci, Edinburgh EH4 2XU, Midlothian, Scotland.
RP Bird, A (reprint author), Univ Edinburgh, Wellcome Trust Ctr Cell Biol, Kings Bldg, Edinburgh EH9 3JR, Midlothian, Scotland.
EM a.bird@ed.ac.uk
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NR 36
TC 113
Z9 118
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0964-6906
J9 HUM MOL GENET
JI Hum. Mol. Genet.
PD AUG 1
PY 2005
VL 14
IS 15
BP 2247
EP 2256
DI 10.1093/hmg/ddi229
PG 10
WC Biochemistry & Molecular Biology; Genetics & Heredity
SC Biochemistry & Molecular Biology; Genetics & Heredity
GA 948OG
UT WOS:000230725000016
PM 16002417
ER
PT J
AU Murphy, GH
Beadle-Brown, J
Wing, L
Gould, J
Shah, A
Holmes, N
AF Murphy, GH
Beadle-Brown, J
Wing, L
Gould, J
Shah, A
Holmes, N
TI Chronicity of challenging behaviours in people with severe intellectual
disabilities and/or autism: A total population sample
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE challenging behaviour; longitudinal; chronicity; intellectual
disabilities
ID SELF-INJURIOUS-BEHAVIOR; FOLLOW-UP; PSYCHOTROPIC MEDICATION;
LEARNING-DIFFICULTIES; MENTAL-RETARDATION; CAMBERWELL COHORT; RETARDED
CHILDREN; INDIVIDUALS; LANGUAGE; INTERVENTION
AB The skills, social impairments and challenging behaviours of a total population of 166 children, with severe intellectual disabilities and/or autism, were assessed through interview with the main carers, when the children were under 15 years old (time 1). Twelve years later, 141 of these individuals were re-assessed, using the same measures (time 2). "Abnormal" behaviours tended to reduce with age and were associated with poorer language skills and poorer quality of social interaction. Individuals with most abnormal behaviours at time 1, tended to have most at time 2. Abnormal behaviour at time 2 was predicted by the presence of abnormal behaviour at time 1, poor expressive language at time 1, poor quality of social interaction at time 1 and a diagnosis of autism/autistic continuum at time 1.
C1 Univ Kent, Tizard Ctr, Canterbury CT2 7LZ, Kent, England.
Leading Edge Psychol, Purley CR2 2ER, England.
Univ Surrey, Dept Psychol, Guildford GU2 5XH, Surrey, England.
RP Murphy, GH (reprint author), Univ Lancaster, Inst Hlth Res, Lancaster LA1 4YT, England.
EM g.h.murphy@lancaster.ac.uk
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NR 75
TC 68
Z9 68
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD AUG
PY 2005
VL 35
IS 4
BP 405
EP 418
DI 10.1007/s10803-005-5030-2
PG 14
WC Psychology, Developmental
SC Psychology
GA 960NU
UT WOS:000231601200002
PM 16134027
ER
PT J
AU Reese, RM
Richman, DM
Belmont, JM
Morse, P
AF Reese, RM
Richman, DM
Belmont, JM
Morse, P
TI Functional characteristics of disruptive behavior in developmentally
disabled children with and without autism
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE autism; behavioral phenotypes; functional analysis; functional
behavioral assessment interview; developmental disabilities; early
childhood assessment; disruptive behavior
ID SELF-INJURIOUS-BEHAVIOR; WILLIAMS-SYNDROME; SEX-DIFFERENCES;
DISABILITIES; PHENOTYPES; DISORDERS
AB Expanding on Reese et al. [2003], functional behavioral assessment interviews [O'Neill et al., 1997] concerning disruptive behavior were conducted with parents of 23 children with autism (6 females, 17 males, chronological ages [CA] 24-60 months) and 23 controls without autism pair-matched for CA, developmental age and sex. All children exhibited frequent disruptive behavior. The interviews suggested that matched control children's disruptive behavior typically functioned to gain attention or items, or to escape demands in general. This was also true for girls with autism. For boys with autism, disruptive behavior more often functioned to (a) escape demands that interfere with repetitive behavior, (b) retain access to an item used in repetitive routines, or (c) avoid idiosyncratically aversive sensory stimuli (e.g., ordinary household noises). These results emphasize the importance of considering behavioral characteristics that are associated with sex and specific disorders or syndromes when conducting functional behavioral assessments.
C1 Univ Kansas, Med Ctr, Dev Disabil Ctr, Dept Pediat, Kansas City, KS 66160 USA.
Univ Kansas, Dept Human Dev & Family Life, Kansas City, KS 66160 USA.
RP Reese, RM (reprint author), Univ Kansas, Med Ctr, Dev Disabil Ctr, Dept Pediat, 3901 Rainbow Blvd, Kansas City, KS 66160 USA.
EM MREESE1@KUMC.EDU
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NR 37
TC 29
Z9 29
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD AUG
PY 2005
VL 35
IS 4
BP 419
EP 428
DI 10.1007/s10803-005-5032-0
PG 10
WC Psychology, Developmental
SC Psychology
GA 960NU
UT WOS:000231601200003
PM 16134028
ER
PT J
AU Lopez, BR
Lincoln, AJ
Ozonoff, S
Lai, Z
AF Lopez, BR
Lincoln, AJ
Ozonoff, S
Lai, Z
TI Examining the relationship between executive functions and restricted,
repetitive symptoms of Autistic Disorder
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE executive function; restricted; repetitive symptoms; stereotyped
behaviors; autistic symptoms; Delis-Kaplin Executive Function Scales
ID INFANTILE-AUTISM; CRYSTALLIZED INTELLIGENCE; STEREOTYPED BEHAVIOR;
DIAGNOSTIC INTERVIEW; NONRETARDED-CHILDREN; WORKING-MEMORY; INDIVIDUALS;
DEFICITS; ADULTS; FLUID
AB The executive function theory was utilized to examine the relationship between cognitive process and the restricted, repetitive symptoms of Autistic Disorder (AD). Seventeen adults with AD were compared to 17 nonautistic controls on a new executive function battery (Delis-Kaplin Executive Function Scales). Restricted, repetitive symptoms were measured by a variety of instruments (i.e., the Autism Diagnostic Observation Schedule, Autism Diagnostic Interview-Revised, Gilliam Autism Rating Scale, and the Aberrant Behavior Checklist). The study replicated the executive function profile that has been reported in adults with AD. In addition to the replication findings, the study found several executive processes (i.e., cognitive flexibility, working memory, and response inhibition) were highly related to the restrictive, repetitive symptoms of AD; whereas, other executive process (i.e., planning and fluency) were not found to be significantly correlated with restricted, repetitive symptoms. Similarly, we found an executive function model consisting of relative strengths and deficits was the best predictor of restricted, repetitive symptoms of autism. The implications for the executive function theory and how the theory predicts core symptoms of autism are discussed.
C1 Univ New Mexico, Ctr Dev & Disabil, Albuquerque, NM 87107 USA.
Scripps Res Inst, La Jolla, CA 92037 USA.
RP Lopez, BR (reprint author), Univ New Mexico, Ctr Dev & Disabil, 2300 Menaul NE, Albuquerque, NM 87107 USA.
EM brilopez@salud.unm.edu
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NR 78
TC 144
Z9 146
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD AUG
PY 2005
VL 35
IS 4
BP 445
EP 460
DI 10.1007/s10803-005-5035-x
PG 16
WC Psychology, Developmental
SC Psychology
GA 960NU
UT WOS:000231601200005
PM 16134030
ER
PT J
AU Fine, SE
Weissman, A
Gerdes, M
Pinto-Martin, J
Zackai, EH
McDonald-McGinn, DM
Emanuel, BS
AF Fine, SE
Weissman, A
Gerdes, M
Pinto-Martin, J
Zackai, EH
McDonald-McGinn, DM
Emanuel, BS
TI Autism spectrum disorders and symptoms in children with molecularly
confirmed 22q11.2 deletion syndrome
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE 22q11.2 Deletion; autism; adaptive behavior
ID PERVASIVE DEVELOPMENTAL DISORDERS; CARDIO-FACIAL SYNDROME;
FAMILY-HISTORY; DIAGNOSTIC INTERVIEW; BEHAVIORAL-PHENOTYPE;
YOUNG-CHILDREN; MICRODELETION; SCHIZOPHRENIA; INTERVENTIONS;
EPIDEMIOLOGY
AB In this study, we assessed the presence of autism spectrum disorders (ASD) among children with a confirmed 22q11.2 deletion (n = 98). The children's caregivers completed screening measures of ASD behaviors, and for those whose scores indicated significant levels of these behaviors, a standardized diagnostic interview (Autism Diagnostic Interview-Revised; ADI-R) was administered. Results demonstrated that over 20% of children (n = 22) were exhibiting significant levels of autism spectrum symptoms based on the screening measures. Based upon the ADI-R, 14 children qualified for a diagnosis of an ASD, and for 11 of those children a diagnosis of autism was most appropriate. These findings increase our knowledge of developmental disorders associated with the 22q11.2 deletion and point to avenues for future investigation.
C1 Childrens Hosp Philadelphia, Dept Psychol, Philadelphia, PA 19104 USA.
Univ Penn, Sch Nursing, Philadelphia, PA 19104 USA.
Childrens Hosp Philadelphia, Div Human Genet & Mol Biol, Philadelphia, PA 19104 USA.
RP Fine, SE (reprint author), EP Bradley Hosp, Brown Med Sch, 1011 Vet Mem Pkwy, E Providence, RI 02915 USA.
EM Sarah_fine@brown.edu
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NR 46
TC 99
Z9 101
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD AUG
PY 2005
VL 35
IS 4
BP 461
EP 470
DI 10.1007/s10803-005-5036-9
PG 10
WC Psychology, Developmental
SC Psychology
GA 960NU
UT WOS:000231601200006
PM 16134031
ER
PT J
AU Beversdorf, DQ
Manning, SE
Hillier, A
Anderson, SL
Nordgren, RE
Walters, SE
Nagaraja, HN
Cooley, WC
Gaelic, SE
Bauman, ML
AF Beversdorf, DQ
Manning, SE
Hillier, A
Anderson, SL
Nordgren, RE
Walters, SE
Nagaraja, HN
Cooley, WC
Gaelic, SE
Bauman, ML
TI Timing of prenatal stressors and autism
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE autism; prenatal; stress; development
ID PERINATAL RISK-FACTORS; INFANTILE-AUTISM; MATERNAL STRESS; RAT PUPS;
PREGNANCY; EXPOSURE; CHILDREN; BRAIN; SUSCEPTIBILITY; ABNORMALITIES
AB Recent evidence supports a role for genetics in autism, but other findings are difficult to reconcile with a purely genetic cause. Pathological changes in the cerebellum in autism are thought to correspond to an event before 30-32 weeks gestation. Our purpose was to determine whether there is an increased incidence of stressors in autism before this time period. Surveys regarding incidence and timing of prenatal stressors were distributed to specialized schools and clinics for autism and Down syndrome, and to mothers of children without neurodevelopmental diagnoses in walk-in clinics. Incidence of stressors during each 4-week block of pregnancy was recorded. Incidence of stressors in the blocks prior to and including the predicted time period (21-32 weeks gestation) in each group of surveys was compared to the other prenatal blocks. A higher incidence of prenatal stressors was found in autism at 21-32 weeks gestation, with a peak at 25-28 weeks. This does support the possibility of prenatal stressors as a potential contributor to autism, with the timing of stressors consistent with the embryological age suggested by neuroanatomical findings seen in the cerebellum in autism. Future prospective studies would be needed to confirm this finding.
C1 Ohio State Univ, Dept Neurol, Med Ctr, Columbus, OH 43210 USA.
Dartmouth Coll Sch Med, Lebanon, NH USA.
Dartmouth Hitchcock Med Ctr, Dept Pediat, Lebanon, NH 03766 USA.
Ohio State Univ, Dept Stat, Columbus, OH 43210 USA.
Child Hlth Associates, Ann Arbor, MI USA.
Massachusetts Gen Hosp, Dept Pediat Neurol, Boston, MA USA.
RP Beversdorf, DQ (reprint author), Ohio State Univ, Dept Neurol, Med Ctr, Means Hall 469,1654 Upham Dr, Columbus, OH 43210 USA.
EM beversdorf-1@medctr.osu.edu
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NR 44
TC 101
Z9 108
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD AUG
PY 2005
VL 35
IS 4
BP 471
EP 478
DI 10.1007/s10803-005-5037-8
PG 8
WC Psychology, Developmental
SC Psychology
GA 960NU
UT WOS:000231601200007
PM 16134032
ER
PT J
AU Rojas, DC
Camou, SL
Reite, ML
Rogers, SJ
AF Rojas, DC
Camou, SL
Reite, ML
Rogers, SJ
TI Planum temporale volume in children and adolescents with autism
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE intelligence; shortforms; assessment; Heschl's gyrus; magnetic resonance
imaging; temporal lobe
ID EARLY INFANTILE-AUTISM; LEFT-RIGHT ASYMMETRIES; HEMISPHERIC ASYMMETRIES;
DEVELOPMENTAL DYSLEXIA; PRAGMATIC IMPAIRMENTS; BRAIN; SCHIZOPHRENIA;
MRI; SIZE; ABNORMALITIES
AB Previous research has revealed a lack of planum temporale (PT) asymmetry in adults with autism. This finding is now extended to children and adolescents with the disorder. MRI scans were obtained from 12 children with autism and 12 gender, handedness and age-matched comparison participants. The volume of gray matter in the PT and Heschl's gyrus (HG) in both hemispheres was measured. PT volume was larger in the left hemisphere than in the right in the comparison, but not the autism group. This specifically reflected reduced volume of the left PT in the autism group. There were noted differences in the overall morphological appearance of the right Sylvian fissure in the autism group, but no volumetric difference in the right PT. No differences in HG volumes were observed between the two groups. Lack of PT asymmetry may suggest an early neurodevelopmental disturbance in autism.
C1 Univ Colorado, Hlth Sci Ctr, Dept Psychiat, Denver, CO 80206 USA.
Calif State Univ Sacramento, Sch Med, Sacramento, CA 95819 USA.
RP Rojas, DC (reprint author), Univ Colorado, Hlth Sci Ctr, Dept Psychiat, Box C268-68 CPH,Rm 2J08, Denver, CO 80206 USA.
EM Don.Rojas@uchsc.edu
RI Rojas, Don/F-4296-2012
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Wise RJS, 2001, BRAIN, V124, P83, DOI 10.1093/brain/124.1.83
NR 53
TC 42
Z9 45
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD AUG
PY 2005
VL 35
IS 4
BP 479
EP 486
DI 10.1007/s10803-005-5038-7
PG 8
WC Psychology, Developmental
SC Psychology
GA 960NU
UT WOS:000231601200008
PM 16134033
ER
PT J
AU Peterson, CC
AF Peterson, CC
TI Mind and body: Concepts of human cognition, physiology and false belief
in children with autism or typical development
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE autism; theory-of-mind; concepts of mind; concepts of biology;
conceptual development
ID METAANALYSIS; LANGUAGE; DEAF
AB This study examined theory of mind (ToM) and concepts of human biology (eyes, heart, brain, lungs and mind) in a sample of 67 children, including 25 high functioning children with autism (age 6-13), plus age-matched and preschool comparison groups. Contrary to Baron-Cohen [1989, Journal of Autism and Developmental Disorders, 19(4), 579-600], most children with autism correctly understood the functions of the brain (84%) and the mind (64%). Their explanations were predominantly mentalistic. They outperformed typically developing preschoolers in understanding inner physiological (heart, lungs) and cognitive (brain, mind) systems, and scored as high as age-matched typical children. Yet, in line with much previous ToM research, most children with autism (60%) failed false belief, and their ToM performance was unrelated to their understanding of. human biology. Results were discussed in relation to neurobiological and social-experiential accounts of the ToM deficit in autism.
C1 Univ Queensland, Sch Psychol, Brisbane, Qld 4072, Australia.
RP Peterson, CC (reprint author), Univ Queensland, Sch Psychol, Brisbane, Qld 4072, Australia.
EM candi@psy.uq.edu.au
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NR 28
TC 7
Z9 7
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD AUG
PY 2005
VL 35
IS 4
BP 487
EP 497
DI 10.1007/s10803-005-5039-6
PG 11
WC Psychology, Developmental
SC Psychology
GA 960NU
UT WOS:000231601200009
PM 16134034
ER
PT J
AU Kraijer, D
de Bildt, A
AF Kraijer, D
de Bildt, A
TI The PDD-MRS: An instrument for identification of autism spectrum
disorders in persons with mental retardation
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE autism; mental retardation; differential diagnosis; PDD-MRS
ID PERVASIVE DEVELOPMENTAL DISORDERS; DIAGNOSTIC INTERVIEW; INTERRATER
RELIABILITY; EPIDEMIOLOGIC ASPECTS; FRAGILE-X; CHILDREN; ADOLESCENTS;
PREVALENCE; BEHAVIOR; CLASSIFICATION
AB The Scale of Pervasive Developmental Disorder in Mentally Retarded Persons (PDD-MRS) is described. The PDD-MRS is a simple classification and screening instrument devised for identification of autistic disorders (of the entire spectrum) in persons with mental retardation from mild to profound levels, age-range 2-55 years. The norms of the scale are based on the research protocols of 1230 Dutch persons with mental retardation. The scale's sensitivity for the entire normative sample was found to be 92.4%; calculated separately for persons at all levels of mentally retarded functioning, male and female persons, speaking and non-speaking persons and five age categories, the sensitivity figures range between 87.0 and 100.0%. The specificity of the scale is also 92.4%; for the aforementioned subgroups separately, the specificity figures range between 84.6 and 95.5%. Roughly similar values for sensitivity and specificity were found when using the scale with severely visually impaired/blind persons; severely hearing-impaired/deaf persons; persons with Down syndrome; male persons with fragile X syndrome. The original version of the PDD-MRS dates from 1990; since then the scale has been widely used in the Netherlands and Belgium. The PDD-MRS should be regarded as a useful instrument for identifying PDD in persons with mental retardation.
C1 Stichting Hendrik van Boeijen, NL-9400 RA Assen, Netherlands.
Univ Groningen, Dept Child & Adolescent Psychiat, NL-9700 AB Groningen, Netherlands.
RP Kraijer, D (reprint author), Stichting Hendrik van Boeijen, POB 30014, NL-9400 RA Assen, Netherlands.
EM dirk.kraijer@vanboeijen.nl
CR ADRIEN JL, 1987, J AUTISM DEV DISORD, V17, P407, DOI 10.1007/BF01487069
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NR 61
TC 20
Z9 20
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD AUG
PY 2005
VL 35
IS 4
BP 499
EP 513
DI 10.1007/s10803-005-5040-0
PG 15
WC Psychology, Developmental
SC Psychology
GA 960NU
UT WOS:000231601200010
PM 16134035
ER
PT J
AU Woodard, C
Groden, J
Goodwin, M
Shanower, C
Bianco, J
AF Woodard, C
Groden, J
Goodwin, M
Shanower, C
Bianco, J
TI The treatment of the behavioral sequelae of autism with
dextromethorphan: A case report
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE autism; dextromethorphan; glutamate
ID DISORDER
AB Dextromethorphan is the d-isomer of levorphenol, and an ingredient in antitussive preparations. A 10 year-old male diagnosed with Autistic Disorder, Pervasive Developmental Disorder, and Generalized Anxiety Disorder was administered this medication initially to treat a medical condition. This became a quasi-experimental ABAB design (A = baseline, B = treatment), with improvements during treatment phases shown in tracked behavioral data and anecdotal reports. Several candidate mechanisms to explain the improvements are offered, including glutamate receptor antagonism. While dextromethorphan is not commonly administered for the treatment of behavioral challenges in this or any population, the results suggest the need for larger-scale, adequately controlled, and methodologically rigorous studies of the potential clinical effects of dextromethorphan.
C1 Groden Ctr, Providence, RI 02906 USA.
RP Woodard, C (reprint author), Groden Ctr, 86 Mt Hope Ave, Providence, RI 02906 USA.
EM cwoodard@grodencenter.org
CR Carlsson ML, 1998, J NEURAL TRANSM, V105, P525, DOI 10.1007/s007020050076
PHILLIPS JA, 1999, ANN M AM SOC HUM GEN
WELCH L, 1992, BRIT J PSYCHIAT, V161, P118, DOI 10.1192/bjp.161.1.118
NR 3
TC 9
Z9 9
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD AUG
PY 2005
VL 35
IS 4
BP 515
EP 518
DI 10.1007/s10803-005-5041-z
PG 4
WC Psychology, Developmental
SC Psychology
GA 960NU
UT WOS:000231601200011
PM 16134036
ER
PT J
AU Hale, CM
Tager-Flusberg, H
AF Hale, CM
Tager-Flusberg, H
TI Brief report: The relationship between discourse deficits and autism
symptomatology
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE ADOS; autism; communication; discourse
ID PERVASIVE DEVELOPMENTAL DISORDERS; PRAGMATIC DEFICITS; CHILDREN;
LANGUAGE; COMMUNICATION; CONVERSATIONS; SPECTRUM; SPEAKERS; PARENTS
AB This study investigated the relationship between discourse deficits to a broader range of other symptoms in 57 children with autism. We hypothesized that autism symptomatology, as measured by the Autism Diagnostic Observation Schedule (ADOS), would be related to the children's difficulty in maintaining an ongoing topic of discourse. Children provided a natural language sample while interacting with one parent. These language samples were coded for the child's use of off-topic or noncontingent utterances. Results showed significant relationships between overall diagnostic symptomatology, and more specifically, deficits in communication as measured by the ADOS-G, and noncontingent discourse. The findings provide diagnostic validity to the ADOS-G and highlight in greater detail the significant communication impairment in autism.
C1 Boston Univ, Sch Med, Dept Anat & Neurobiol, Boston, MA 02118 USA.
Harvard Univ, Sch Med, Dept Psychiat, Childrens Hosp, Cambridge, MA 02138 USA.
RP Tager-Flusberg, H (reprint author), Boston Univ, Sch Med, Dept Anat & Neurobiol, 715 Albany St,L-814, Boston, MA 02118 USA.
EM htagerf@bu.edu
RI Tager-Flusberg, Helen/D-5265-2009
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NR 35
TC 16
Z9 17
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD AUG
PY 2005
VL 35
IS 4
BP 519
EP 524
DI 10.1007/s10803-005-5065-4
PG 6
WC Psychology, Developmental
SC Psychology
GA 960NU
UT WOS:000231601200012
PM 16134037
ER
PT J
AU Fein, D
Dixon, P
Paul, J
Levin, H
AF Fein, D
Dixon, P
Paul, J
Levin, H
TI Brief report: Pervasive developmental disorder can evolve into ADHD:
Case illustrations
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE ADHD; autism; loss of the PDD diagnosis; outcome; PDD
ID DEFICIT-HYPERACTIVITY DISORDER; AUTISM; DOPAMINE; CHILDREN; MODEL
AB Despite prominent attentional symptoms in Pervasive Developmental Disorders (PDD) the relationship between PDD and Attention Deficit Hyperactivity Disorder (ADHD) has received little direct examination. In addition, outcome studies of children with PDD often focus on language, educational placement, or adaptive skills, but seldom on loss of the PDD diagnosis or change to another clinical syndrome. We present three cases in detail, and tabular data on eight more, that illustrate a clinical presentation in which prototypical cases of PDD evolve into clear-cut cases of ADHD from early to middle childhood.
C1 Univ Connecticut, Dept Psychol, Storrs, CT 06269 USA.
RP Fein, D (reprint author), Univ Connecticut, Dept Psychol, 406 Babbidge Rd, Storrs, CT 06269 USA.
EM deborah.fein@uconn.edu
CR Albrant D H, 2000, J Am Pharm Assoc (Wash), V40, P599
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NR 30
TC 31
Z9 33
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD AUG
PY 2005
VL 35
IS 4
BP 525
EP 534
DI 10.1007/s10803-005-5066-3
PG 10
WC Psychology, Developmental
SC Psychology
GA 960NU
UT WOS:000231601200013
PM 16134038
ER
PT J
AU Starr, E
AF Starr, E
TI Autism spectrum disorders: Interventions and treatments for children and
youth
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Book Review
C1 Univ Windsor, Windsor, ON N9B 3P4, Canada.
RP Starr, E (reprint author), Univ Windsor, Windsor, ON N9B 3P4, Canada.
CR Gresham FM, 1999, SCHOOL PSYCHOL REV, V28, P559
National Research Council, 2001, ED CHILDR AUT
Odom S. L., 2003, FOCUS AUTISM OTHER D, V18, P166, DOI DOI 10.1177/10883576030180030401
Simpson R. L., 2005, AUTISM SPECTRUM DISO
NR 4
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD AUG
PY 2005
VL 35
IS 4
BP 535
EP 537
DI 10.1007/s10803-005-5067-2
PG 3
WC Psychology, Developmental
SC Psychology
GA 960NU
UT WOS:000231601200014
ER
PT J
AU Witwer, A
Lecavalier, L
AF Witwer, A
Lecavalier, L
TI Treatment incidence and patterns in children and adolescents with autism
spectrum disorders
SO JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY
LA English
DT Article
ID PERVASIVE DEVELOPMENTAL DISORDERS; PSYCHOACTIVE MEDICINES;
MENTAL-RETARDATION; PRESCHOOL-CHILDREN; FOLLOW-UP; DISABILITIES;
PREVALENCE; INDIVIDUALS; BEHAVIOR; SOCIETY
AB This study examined the treatment rates and patterns in children and adolescents with autism spectrum disorders (ASDs). Data were collected on 353 nonreferred children and adolescents (mean age 9.5 +/- 3.9 years; range 3-21 years) with ASDs from public schools across Ohio. Parents provided information on the use of psychotropic medicines, vitamins, supplements, and modified diets. They also completed measures of social competence, problem behavior, and adaptive behavior. Results indicated that 46.7% of subjects had taken at least one psychotropic medication in the past year. In addition, 17.3% of subjects had taken some type of specially formulated vitamin or supplement, 15.5% were on a modified diet, 11.9% had some combination of psychotropic medication and an alternative treatment, and 4.8% had taken an anticonvulsant. Logistic regressions indicated that greater age, lower adaptive skills and social competence, and higher levels of problem behavior were associated with greater medication use. This was the first study to focus exclusively on a younger population, to survey patterns of modified diets, and to obtain standardized ratings of social competence, problem behaviors, and adaptive behavior in relation to medication use. The results of this study highlight the need for more research on psychotropic medication in children and adolescents with ASDs.
C1 Ohio State Univ, Nisonger Ctr, Columbus, OH 43210 USA.
Ohio State Univ, Dept Psychol, Columbus, OH 43210 USA.
RP Lecavalier, L (reprint author), Ohio State Univ, Nisonger Ctr, 305 McCampbell Hall,1581 Dodd Dr, Columbus, OH 43210 USA.
EM lecavalier.1@osu.edu
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NR 30
TC 53
Z9 53
PU MARY ANN LIEBERT INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1044-5463
J9 J CHILD ADOL PSYCHOP
JI J. Child Adolesc. Psychopharmacol.
PD AUG
PY 2005
VL 15
IS 4
BP 671
EP 681
DI 10.1089/cap.2005.15.671
PG 11
WC Pediatrics; Pharmacology & Pharmacy; Psychiatry
SC Pediatrics; Pharmacology & Pharmacy; Psychiatry
GA 973EZ
UT WOS:000232507000015
PM 16190798
ER
PT J
AU Hellings, JA
Weckbaugh, M
Nickel, EJ
Cain, SE
Zarcone, JR
Reese, RM
Hall, S
Ermer, DJ
Tsai, LY
Schroeder, SR
Cook, EH
AF Hellings, JA
Weckbaugh, M
Nickel, EJ
Cain, SE
Zarcone, JR
Reese, RM
Hall, S
Ermer, DJ
Tsai, LY
Schroeder, SR
Cook, EH
TI A double-blind, placebo-controlled study of valproate for aggression in
youth with pervasive developmental disorders
SO JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY
LA English
DT Article
ID MENTAL-RETARDATION; DIVALPROEX SODIUM; ABERRANT BEHAVIOR; RISPERIDONE;
CHILDREN; AUTISM; ADULTS; ACID; DISABILITIES; ADOLESCENTS
AB Objective: The aim of this study was to study valproate efficacy and safety for aggression in children and adolescents with pervasive developmental disorders (PDD).
Methods: In this prospective double-blind, placebo-controlled study, 30 subjects (20 boys, 10 girls) 6-20 years of age with PDD and significant aggression were randomized and received treatment with valproate WPA) or placebo (PBO) for 8 weeks as outpatients. Mean VPA trough blood levels were 75.5 mcg/mL at week 4 and 77.8 mcg/mL at week 8.
Results: No treatment difference was observed statistically between VIA and PBO groups. The Aberrant Behavior Checklist-Community Scale (ABC-C) Irritability subscale was the primary outcome measure (p = 0.65), and CGI-Improvement (p = 0.16) and OAS (p = 0.96) were secondary outcome measures. Increased appetite and skin rash were significant side effects. Only 1 subject was dropped from the study owing to side effects, notably a spreading skin rash, which then resolved spontaneously. Two subjects receiving VIA developed increased serum ammonia levels, one with an associated parent report of slurred speech and mild cognitive slowing. Poststudy, of 16 VIA and PBO subjects receiving VIA, 10 subjects demonstrated sustained response, 4 of whom later attempted taper, with significant relapse of aggression.
Conclusion: The present negative findings cannot be viewed as conclusive, partly owing to the large placebo response, subject heterogeneity, and size of the groups. Larger studies are needed to expand upon these findings.
C1 Univ Kansas, Med Ctr, Dept Psychiat & Behav Sci, Kansas City, KS 66160 USA.
Univ Kansas, Med Ctr, Dept Dev Disabilities Ctr, Kansas City, KS 66160 USA.
Univ Kansas, Med Ctr, Dept Prevent Med & Publ Hlth, Kansas City, KS 66160 USA.
Univ S Dakota, Vermillion, SD 57069 USA.
Univ Michigan, Ann Arbor, MI 48109 USA.
Univ Kansas, Lifespan Inst, Kansas City, KS USA.
Univ Illinois, Chicago, IL USA.
RP Hellings, JA (reprint author), Univ Kansas, Med Ctr, Dept Psychiat & Behav Sci, 3901 Rainbow Blvd,MS 4015, Kansas City, KS 66160 USA.
EM jhelling@kumc.edu
CR AMAN MG, 1995, AM J MENT RETARD, V100, P283
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NR 31
TC 62
Z9 62
PU MARY ANN LIEBERT INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1044-5463
J9 J CHILD ADOL PSYCHOP
JI J. Child Adolesc. Psychopharmacol.
PD AUG
PY 2005
VL 15
IS 4
BP 682
EP 692
DI 10.1089/cap.2005.15.682
PG 11
WC Pediatrics; Pharmacology & Pharmacy; Psychiatry
SC Pediatrics; Pharmacology & Pharmacy; Psychiatry
GA 973EZ
UT WOS:000232507000016
PM 16190799
ER
PT J
AU Ng, SSM
Chow, BKC
Wong, VCN
AF Ng, SSM
Chow, BKC
Wong, VCN
TI The human secretin gene in children with autistic spectrum disorder:
Screening for polymorphisms and mutations
SO JOURNAL OF CHILD NEUROLOGY
LA English
DT Article
ID PLACEBO-CONTROLLED TRIAL; SUSCEPTIBILITY GENES; DOUBLE-BLIND; RECEPTOR;
16P; 7Q
AB We screened 29 children with autism for mutation in the human secretin gene using single-strand conformation polymorphism. No mutation was detected in exon 2, 3, or 4. Polymerase chain reaction and DNA sequence of 5' variable number of tandem repeats showed two polymorphisms with deletion or duplication of a repeat unit that failed to show any gene expression with transient transfection assay. We did not find evidence of a relationship between human secretin gene mutation and autism.
C1 Univ Hong Kong, Queen Mary Hosp, Dept Paediat & Adolescent Med, Div Neurodev Paediat, Hong Kong, Hong Kong, Peoples R China.
Univ Hong Kong, Inst Mol Biol, Hong Kong, Hong Kong, Peoples R China.
Univ Hong Kong, Dept Zool, Hong Kong, Hong Kong, Peoples R China.
RP Wong, VCN (reprint author), Univ Hong Kong, Queen Mary Hosp, Dept Paediat & Adolescent Med, Div Neurodev Paediat, Hong Kong, Hong Kong, Peoples R China.
EM vcnwong@hkucc.hku.hk
RI Chow, Billy/D-3064-2009
OI Chow, Billy/0000-0003-3390-0307
CR Auranen M, 2000, MOL PSYCHIATR, V5, P320, DOI 10.1038/sj.mp.4000708
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NR 26
TC 2
Z9 2
PU B C DECKER INC
PI HAMILTON
PA 20 HUGHSON ST SOUTH, PO BOX 620, L C D 1, HAMILTON, ONTARIO L8N 3K7,
CANADA
SN 0883-0738
J9 J CHILD NEUROL
JI J. Child Neurol.
PD AUG
PY 2005
VL 20
IS 8
BP 701
EP 704
DI 10.1177/08830738050200081501
PG 4
WC Clinical Neurology; Pediatrics
SC Neurosciences & Neurology; Pediatrics
GA 006XL
UT WOS:000234930900015
PM 16225821
ER
PT J
AU Skellern, C
Schluter, P
McDowell, M
AF Skellern, C
Schluter, P
McDowell, M
TI From complexity to category: Responding to diagnostic uncertainties of
autistic spectrum disorders
SO JOURNAL OF PAEDIATRICS AND CHILD HEALTH
LA English
DT Article
DE ASD; autism; diagnosis; uncertainty
ID PERVASIVE DEVELOPMENTAL DISORDERS; CLASSIFICATION
AB Objective: Recent data from Education Queensland has identified rising numbers of children receiving diagnoses of autistic spectrum disorder (ASD). Faced with funding diagnostic pressures, in clinical situations that are complex and inherently uncertain, it is possible that specialists err on the side of a positive diagnosis. This study examines the extent to which possible overinclusion of ASD diagnosis may exist in the presence of uncertainty and factors potentially related to this practice in Queensland.
Methods: Using anonymous self-report, all Queensland child psychiatrists and paediatricians who see paediatric patients with development/behavioural problems were surveyed and asked whether they had ever specified an ASD diagnosis in the presence of diagnostic uncertainty. Using logistic regression, elicited responses to the diagnostic uncertainty questions were related to other clinical- and practice-related characteristics.
Results: Overall, 58% of surveyed psychiatrists and paediatricians indicated that, in the face of diagnostic uncertainty, they had erred on the side of providing an ASD diagnosis for educational ascertainment and 36% of clinicians had provided an autism diagnosis for Carer's Allowance when Centrelink diagnostic specifications had not been met.
Conclusion: In the absence of definitive biological markers, ASD remains a behavioural diagnosis that is often complex and uncertain. In response to systems that demand a categorical diagnostic response, specialists are providing ASD diagnoses, even when uncertain. The motivation for this practice appears to be a clinical risk/benefit analysis of what will achieve the best outcomes for children. It is likely that these practices will continue unless systems change eligibility to funding based on functional impairment rather than medical diagnostic categories.
C1 Univ Queensland, Sch Populat Hlth, St Lucia, Qld 4067, Australia.
Child Dev Network, Brisbane, Qld, Australia.
Auckland Univ Technol, Fac Hlth, Auckland, New Zealand.
RP Skellern, C (reprint author), Community Child Hlth Serv, 184 St Pauls Terrace, Fortitude Valley, Qld 4006, Australia.
EM Catherine_Skellern@health.qld.gov.au
RI Skellern, Catherine/B-9175-2011; McDowell, Michael/G-5080-2013
CR ADSETT D, 2003, TRENDS AUTISTIC SPEC
American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th
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Prior M, 2003, J PAEDIATR CHILD H, V39, P81, DOI 10.1046/j.1440-1754.2003.00097.x
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NR 18
TC 23
Z9 24
PU BLACKWELL PUBLISHING
PI OXFORD
PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND
SN 1034-4810
J9 J PAEDIATR CHILD H
JI J. Paediatr. Child Health
PD AUG
PY 2005
VL 41
IS 8
BP 407
EP 412
DI 10.1111/j.1440-1754.2005.00634.x
PG 6
WC Pediatrics
SC Pediatrics
GA 952GV
UT WOS:000230992900003
PM 16101973
ER
PT J
AU Skellern, C
McDowell, M
Schluter, P
AF Skellern, C
McDowell, M
Schluter, P
TI Diagnosis of autistic spectrum disorders in Queensland: Variations in
practice
SO JOURNAL OF PAEDIATRICS AND CHILD HEALTH
LA English
DT Article
DE autism; child development disorders; diagnosis; pervasive; specialist
ID INTERVIEW
AB Objective: For both paediatricians and child psychiatrists, referrals to assess possible autistic spectrum disorders (ASD) are increasing. This study examines current practices of medical specialists in the assessment of these disorders.
Methods: An anonymous, self-report questionnaire was sent to all Queensland paediatricians and child psychiatrists. The survey elicited frequencies of consultation for ASD, diagnostic method, advice provided and perceived adequacy of training for this work.
Results: Responses were received from 79 (85%) eligible paediatricians and 26 (58%) eligible child psychiatrists. For one-third of all clinicians, new consultations for possible ASD occurred as often as 2-3 times per week. Most specialists approached the clinical diagnosis of ASD by considering history from different sources and professional assessments. Paediatricians (86%) were more likely than child psychiatrists (62%) to request genetic studies for children with severe autism (P = 0.01). Both general paediatricians and developmental paediatricians perceived level of training for possible ASD consultations was significantly worse than child psychiatrists (P < 0.001 and P = 0.02, respectively), but no difference was found between paediatric groups (P = 0.27). Perceived adequacy of specialist training was not associated with length of experience in clinical practice.
Conclusion: Medical practice in Queensland around diagnosis of ASD is characterized by considerable variability. There is still a long way to go if we are to achieve consistency around medical issues of organic diagnosis and practices impacting on health as well as consideration of differential developmental diagnoses. The finding that recently trained paediatricians felt just as unprepared for this work as their older colleagues suggests that the graduate training response to this 'new morbidity' has not been adequate.
C1 Univ Queensland, Community Child Hlth Serv, Sch Populat Hlth, Fortitude Valley, Qld 4006, Australia.
Univ Queensland, Child Dev Network, Brisbane, Qld, Australia.
Auckland Univ Technol, Fac Hlth, Auckland, New Zealand.
RP Skellern, C (reprint author), Univ Queensland, Community Child Hlth Serv, Sch Populat Hlth, 184 St Pauls TCE, Fortitude Valley, Qld 4006, Australia.
EM Catherine_Skellern@health.qld.gov.au
RI Skellern, Catherine/B-9175-2011; McDowell, Michael/G-5080-2013
CR *AACAP, 1999, J AM ACAD CHILD ADOL, V38, pS32
American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th
Attwood T., 1998, ASPERGERS SYNDROME G
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Leekam SR, 2002, J CHILD PSYCHOL PSYC, V43, P327, DOI 10.1111/1469-7610.00024
LORD C, 1989, J AUTISM DEV DISORD, V19, P185, DOI 10.1007/BF02211841
LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
*MICR, 2000, MICR ACC COMP PROGR
OBERKLAID F, 1988, AUST PAEDIATR J, V24, P5
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NR 19
TC 8
Z9 9
PU BLACKWELL PUBLISHING
PI OXFORD
PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND
SN 1034-4810
J9 J PAEDIATR CHILD H
JI J. Paediatr. Child Health
PD AUG
PY 2005
VL 41
IS 8
BP 413
EP 418
DI 10.1111/j.1440-1754.2005.00667.x
PG 6
WC Pediatrics
SC Pediatrics
GA 952GV
UT WOS:000230992900004
PM 16101974
ER
PT J
AU Couturier, JL
Speechley, KN
Steele, M
Norman, R
Stringer, B
Nicolson, R
AF Couturier, JL
Speechley, KN
Steele, M
Norman, R
Stringer, B
Nicolson, R
TI Parental perception of sleep problems in children of normal intelligence
with pervasive developmental disorders: Prevalence, severity, and
pattern
SO JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
LA English
DT Article
DE pervasive developmental disorder; sleep problem; parent survey;
prevalence
ID AUTISTIC-CHILDREN; INDIVIDUALS; CHILDHOOD
AB Objective: This study compares parents' perceptions of the prevalence, severity, and pattern of sleep problems in children of normal intelligence with pervasive developmental disorders (PDDs) with a normative comparison group of children. Method: A survey including the Children's Sleep Habits Questionnaire was mailed to a sample of parents of children (age range 5-12 years) with PDDs (diagnosed by the Autism Diagnostic Interview-Revised) obtained by chart review of the past 7 years and to parents of comparison children matched on age, gender, and postal code. Results: The response rate in the PDD group was 82.2% (37/45) and 55.8% (43/77) in the comparison group. By individually matching, 23 pairs were obtained. The prevalence of sleep problems in the PDD group was reported by parents as being significantly higher than in the comparison group (78% and 26%, respectively; p < .002), as was the severity (mean score 48.2 and 39.0, respectively; p < .001). Values for four of eight sleep subscales including sleep onset delay, sleep duration, sleep anxiety, and parasomnias were significantly higher in the PDD group. Conclusions: Parents report that sleep problems are significantly more prevalent and severe in children of normal intelligence with PDDs compared with normally developing children, and the pattern appears diverse. Sleep problems in children with PDDs require further research and clinical attention.
C1 Univ Western Ontario, Dept Psychiat, London, ON N6A 3K7, Canada.
Univ Western Ontario, Dept Pediat, London, ON N6A 3K7, Canada.
Univ Western Ontario, Dept Epidemiol & Biostat, London, ON, Canada.
RP Couturier, JL (reprint author), Child & Adolescent Mental Hlth Care Eating Disord, London Hlth Sci Ctr, 1st Floor,Room 105, London, ON N6C 2V5, Canada.
EM jlcoutur@uwo.ca
RI Nicolson, Robert/E-4797-2011
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NR 31
TC 58
Z9 63
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0890-8567
J9 J AM ACAD CHILD PSY
JI J. Am. Acad. Child Adolesc. Psychiatr.
PD AUG
PY 2005
VL 44
IS 8
BP 815
EP 822
DI 10.1097/01.chi.0000166377.22651.87
PG 8
WC Psychology, Developmental; Pediatrics; Psychiatry
SC Psychology; Pediatrics; Psychiatry
GA 948EV
UT WOS:000230699700013
PM 16034284
ER
PT J
AU Kratochvil, CJ
Findling, RL
McDougle, CJ
Scahill, L
Hamarman, S
AF Kratochvil, CJ
Findling, RL
McDougle, CJ
Scahill, L
Hamarman, S
TI Pharmacological management of agitation and aggression in an adolescent
with autism
SO JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
LA English
DT Article
ID CHILDREN; RISPERIDONE; QUETIAPINE; DISORDER
C1 Univ Nebraska, Med Ctr, Nebraska Med Ctr 985581, Med Ctr, Omaha, NE 68198 USA.
Case Western Reserve Univ, Univ Hosp Cleveland, Dept Psychiat, Cleveland, OH USA.
Case Western Reserve Univ, Univ Hosp Cleveland, Dept Pediat, Cleveland, OH USA.
Indiana Univ, Sch Med, Dept Psychiat, Indianapolis, IN 46202 USA.
Yale Univ, Ctr Child Study, Hartford, CT USA.
Stanley Lamm Inst Child Neurol & Dev Med, New York, NY USA.
Suny Downstate Med Sch, New York, NY USA.
RP Kratochvil, CJ (reprint author), Univ Nebraska, Med Ctr, Nebraska Med Ctr 985581, Med Ctr, Omaha, NE 68198 USA.
EM ckratoch@unmc.edu
CR American Diabetes Association American Psychiatric Association American Association of Clinical Endocrinologists North American Association for the Study of Obesity, 2004, DIABETES CARE, V27, P596
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NR 7
TC 2
Z9 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0890-8567
J9 J AM ACAD CHILD PSY
JI J. Am. Acad. Child Adolesc. Psychiatr.
PD AUG
PY 2005
VL 44
IS 8
BP 829
EP 832
DI 10.1097/01.chi.0000166380.68392.4b
PG 4
WC Psychology, Developmental; Pediatrics; Psychiatry
SC Psychology; Pediatrics; Psychiatry
GA 948EV
UT WOS:000230699700015
PM 16034286
ER
PT J
AU Seeman, C
AF Seeman, C
TI Making peace with autism: One family's story of struggle, discovery, and
unexpected gifts
SO LIBRARY JOURNAL
LA English
DT Book Review
C1 Univ Toledo Libs, Toledo, OH 43606 USA.
RP Seeman, C (reprint author), Univ Toledo Libs, Toledo, OH 43606 USA.
CR Senator S., 2005, MAKING PEACE AUTISM
NR 1
TC 0
Z9 0
PU BOWKER MAGAZINE GROUP CAHNERS MAGAZINE DIVISION
PI NEW YORK
PA 249 W 17TH ST, NEW YORK, NY 10011 USA
SN 0363-0277
J9 LIBR J
JI Libr. J.
PD AUG
PY 2005
VL 130
IS 13
BP 105
EP 105
PG 1
WC Information Science & Library Science
SC Information Science & Library Science
GA 956KF
UT WOS:000231297900317
ER
PT J
AU Poehlmann, J
Clements, M
Abbeduto, L
Farsad, V
AF Poehlmann, J
Clements, M
Abbeduto, L
Farsad, V
TI Family experiences associated with a child's diagnosis of fragile X or
Down syndrome: Evidence for disruption and resilience
SO MENTAL RETARDATION
LA English
DT Article
ID DEVELOPMENTAL-DISABILITIES; MENTAL-RETARDATION; MOTHERS; ADULTS;
PERCEPTIONS; BIRTH; RACE; ADAPTATION; PARENTS; AUTISM
AB Although previous findings have shown that parents react intensely to the initial diagnosis of their child's disability, studies focused on long-term outcomes and adjustment are needed. We interviewed 21 mothers whose adolescent or young adult was diagnosed with Down syndrome or fragile X syndrome. Qualitative analysis of data focused on the diagnostic process and the child's development revealed emergent themes: importance of context, variations in emotional reactions to the diagnosis, use of specific coping strategies, and changes in family adaptation over time. Results indicate most families experienced elements of disruption and resilience in their reactions to the diagnosis, although different patterns emerged for each syndrome group. Maternal descriptions highlighted positive attributes that contributed to family well-being and behavioral challenges that were a source of family stress.
C1 Univ Wisconsin, Madison, WI 53706 USA.
Wisconsin Ctr Educ Res, Madison, WI 53706 USA.
Univ Wisconsin, Waisman Ctr 463, Madison, WI 53705 USA.
RP Poehlmann, J (reprint author), Univ Wisconsin, 1430 Linden Dr, Madison, WI 53706 USA.
EM poehlmann@waisman.wisc.edu
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NR 39
TC 32
Z9 32
PU AMER ASSOC MENTAL RETARDATION
PI WASHINGTON
PA 444 N CAPITOL ST, NW, STE 846, WASHINGTON, DC 20001-1512 USA
SN 0047-6765
J9 MENT RETARD
JI Ment. Retard.
PD AUG
PY 2005
VL 43
IS 4
BP 255
EP 267
DI 10.1352/0047-6765(2005)43[255:FEAWAC]2.0.CO;2
PG 13
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA 951EB
UT WOS:000230910800002
PM 16000026
ER
PT J
AU Molloy, CA
Keddache, M
Martin, LJ
AF Molloy, CA
Keddache, M
Martin, LJ
TI Evidence for linkage on 21q and 7q in a subset of autism characterized
by developmental regression
SO MOLECULAR PSYCHIATRY
LA English
DT Article
DE autistic disorder; developmental regression; chromosome 21; AGRE
ID GENOMEWIDE SCREEN; SPECTRUM DISORDERS; GENOMIC SCREEN; SUSCEPTIBILITY
GENES; OXIDATIVE STRESS; DOWN-SYNDROME; CHILDREN; PROTEINS; FAMILIES;
ETIOLOGY
AB Autism is a pervasive developmental disorder with a strong genetic component. While candidate regions of the genome have been identified, location of genes conferring susceptibility to autism has been hindered by the heterogeneity within this clinically defined disorder, and the likely contribution of many genes of weak effect. Subsetting samples on the basis of distinct, nondiagnostic clinical features has been recommended to decrease sample heterogeneity. In this study, linkage analysis was performed on a subset of families in the database of the Autism Genetic Resource Exchange (AGRE). This set of autism-affected relative pairs ( n = 34) was also concordant for a history of developmental regression as measured by the Autism Diagnostic Interview - Revised (ADI-R). In this sample, a maximum multipoint LOD score of 3.4 under the dominant mode of inheritance and an NPL score of 3.0 ( P = 1.3 x 10(-3)) were observed on chromosome 21 near D21S1437. On chromosome 7 near D7S483 a LOD score of 2.0 under the dominant mode of inheritance and an NPL score of 3.7 ( P = 7.9 x 10(-5)) were observed. Genetic elements in these regions of 21q and 7q are likely to confer susceptibility to autism or modify the disease presentation in a subgroup of children characterized by a history of developmental regression.
C1 Univ Cincinnati, Coll Med, Dept Pediat, Cincinnati Childrens Hosp Med Ctr,Ctr Epidemiol &, Cincinnati, OH 45229 USA.
Univ Cincinnati, Coll Med, Dept Pediat, Cincinnati Childrens Hosp Med Ctr,Div Dev Disabil, Cincinnati, OH USA.
Univ Cincinnati, Coll Med, Dept Pediat, Cincinnati Childrens Hosp Med Ctr,Div Human Genet, Cincinnati, OH USA.
RP Molloy, CA (reprint author), Univ Cincinnati, Coll Med, Dept Pediat, Cincinnati Childrens Hosp Med Ctr,Ctr Epidemiol &, 3333 Burnet Ave MLC 5041, Cincinnati, OH 45229 USA.
EM Cynthia.molloy@cchmc.org
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NR 51
TC 46
Z9 53
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1359-4184
J9 MOL PSYCHIATR
JI Mol. Psychiatr.
PD AUG
PY 2005
VL 10
IS 8
BP 741
EP 746
DI 10.1038/sj.mp.4001691
PG 6
WC Biochemistry & Molecular Biology; Neurosciences; Psychiatry
SC Biochemistry & Molecular Biology; Neurosciences & Neurology; Psychiatry
GA 949ZQ
UT WOS:000230827800005
PM 15940295
ER
PT J
AU Alarcon, M
Yonan, AL
Gilliam, TC
Cantor, RM
Geschwind, DH
AF Alarcon, M
Yonan, AL
Gilliam, TC
Cantor, RM
Geschwind, DH
TI Quantitative genome scan and Ordered-Subsets Analysis of autism
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SO MOLECULAR PSYCHIATRY
LA English
DT Article
DE autism spectrum disorder; language; linkage; nonparametric; sibpair
ID LINKAGE ANALYSIS; SUSCEPTIBILITY LOCI; COMPLEX TRAITS; CHROMOSOME 7Q;
DISORDER; SCREEN; GENETICS; SPEECH; LOCALIZATION; INDIVIDUALS
AB Autism is a neurodevelopmental syndrome with early childhood onset and deficits in three behavioral and cognitive dimensions: language, social skills and repetitive or restrictive behaviors. We hypothesized that using these endophenotypes would provide more power to detect linkage than the diagnosis of autism. Previously, we reported results for a nonparametric quantitative trait locus (QTL) genome scan in 152 families with autism, which revealed a linkage peak related to spoken language on 7q35. Here, we present the results of a nonparametric QTL scan of autism endophenotypes in 291 multiplex families, including the original 152. The strongest evidence for an 'age at first word' QTL was on chromosomes 3q at 147 cM ( Z = 3.10, P<0.001), and 17q at 93 cM ( Z = 2.84, P = 0.002), both represent novel susceptibility loci for autism endophenotypes. There was also support for a previously identified autism peak on chromosome 17 at 43 cM ( Z = 2.22, P = 0.013) with 'age at first phrase'. The 7q35 language peak was attenuated ( Z = 2.05, P = 0.02) compared with the original finding. To explore the possibility of increased heterogeneity resulting from the addition of 135 families to the sample, we conducted an Ordered-Subsets Analysis on chromosome 7; these results suggest that the 132 autism families with the earliest average age at first word are responsible for the QTL on 7q35. This locus on 7q35 may harbor a gene contributing variability in spoken language that is not uniquely related to language delay in autism.
C1 Univ Calif Los Angeles, Sch Med, Ctr Neurobehav Genet, Dept Neurol, Los Angeles, CA 90095 USA.
Neuropsychiat Res Inst, Los Angeles, CA 90095 USA.
Dept Genet & Dev, Columbia Genome Ctr, New York, NY USA.
Columbia Univ, Dept Psychiat, New York, NY USA.
Univ Calif Los Angeles, Sch Med, Dept Human Genet, Los Angeles, CA USA.
Univ Calif Los Angeles, Sch Med, Dept Pediat, Los Angeles, CA 90024 USA.
RP Geschwind, DH (reprint author), Univ Calif Los Angeles, Sch Med, Ctr Neurobehav Genet, Dept Neurol, 710 Westwood Plaza,RNRC 1-145, Los Angeles, CA 90095 USA.
EM malarcon@ucla.edu; dhg@ucla.edu
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Yonan AL, 2003, AM J HUM GENET, V73, P886, DOI 10.1086/378778
NR 43
TC 82
Z9 86
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1359-4184
J9 MOL PSYCHIATR
JI Mol. Psychiatr.
PD AUG
PY 2005
VL 10
IS 8
BP 747
EP 757
DI 10.1038/sj.mp.4001666
PG 11
WC Biochemistry & Molecular Biology; Neurosciences; Psychiatry
SC Biochemistry & Molecular Biology; Neurosciences & Neurology; Psychiatry
GA 949ZQ
UT WOS:000230827800006
PM 15824743
ER
PT J
AU Ray, MA
Graham, AJ
Lee, M
Perry, RH
Court, JA
Perry, EK
AF Ray, MA
Graham, AJ
Lee, M
Perry, RH
Court, JA
Perry, EK
TI Neuronal nicotinic acetylcholine receptor subunits in autism: An
immunohistochemical investigation in the thalamus
SO NEUROBIOLOGY OF DISEASE
LA English
DT Article
DE autism; neuronal nicotinic acetylcholine receptor; thalamus;
paraventricular nucleus; nucleus reuniens; glutamic acid decarboxylase;
GABA
ID GLUTAMIC-ACID DECARBOXYLASE; POSITRON-EMISSION-TOMOGRAPHY; RAT STRIATAL
SYNAPTOSOMES; ALPHA-CONOTOXIN-MII; CEREBRAL-CORTEX; NEUROANATOMICAL
ABNORMALITIES; LINKAGE-DISEQUILIBRIUM; REACTIVE ASTROCYTES;
PARKINSONS-DISEASE; ALZHEIMERS-DISEASE
AB The cholinergic system has been implicated in the development of autism on the basis of neuronal nicotinic acetylcholine receptor (nAChR) losses in cerebral and cerebellar cortex. In the present study, the first to explore nAChRs in the thalamus in autism, alpha 4, alpha 7 and beta 2 nAChR subunit expression in thalamic nuclei of adult individuals with autism (n = 3) and age-matched control cases (n = 3) was investigated using immunochemical methods. Loss of alpha 7- and beta 2- (but not alpha 4-) immunoreactive neurons occurred in the paraventricular nucleus (PV) and nucleus reuniens in autism. Preliminary results indicated glutamic acid decarboxylase immunoreactivity occurred at a low level in PV, co-expressed with alpha 7 in normal and autistic cases and was not reduced in autism. This suggested loss of neuronal alpha 7 in autism is not caused by loss of GABAergic neurons. These findings indicate nicotinic abnormalities that occur in the thalamus in autism which may contribute to sensory or attentional deficits. (c) 2005 Elsevier Inc. All rights reserved.
C1 Univ Newcastle Upon Tyne, Newcastle Gen Hosp, Inst Ageing & Hlth, Newcastle Upon Tyne NE4 6BE, Tyne & Wear, England.
Newcastle Gen Hosp, Dept Neuropathol, Newcastle Upon Tyne NE4 6BE, Tyne & Wear, England.
RP Ray, MA (reprint author), Univ Newcastle Upon Tyne, Newcastle Gen Hosp, Inst Ageing & Hlth, MRC Bldg,Westgate Rd, Newcastle Upon Tyne NE4 6BE, Tyne & Wear, England.
EM Melissa.Ray@ncl.ac.uk
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NR 78
TC 22
Z9 23
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0969-9961
J9 NEUROBIOL DIS
JI Neurobiol. Dis.
PD AUG
PY 2005
VL 19
IS 3
BP 366
EP 377
DI 10.1016/j.nbd.2005.01.017
PG 12
WC Neurosciences
SC Neurosciences & Neurology
GA 950LI
UT WOS:000230858200002
PM 16023579
ER
PT J
AU Mosconi, MW
Mack, PB
McCarthy, G
Pelphrey, KA
AF Mosconi, MW
Mack, PB
McCarthy, G
Pelphrey, KA
TI Taking an "intentional stance" on eye-gaze shifts: A functional
neuroimaging study of social perception in children
SO NEUROIMAGE
LA English
DT Article
DE social perception; superior temporal sulcus; child development; fMRI;
eye gaze; biological motion
ID SUPERIOR TEMPORAL SULCUS; FACE RECOGNITION; ACTIVATION; FMRI; ATTENTION;
DIRECTION; AUTISM; ADULTS; CUES; MIND
AB During middle childhood, children develop an increasing understanding of intentions and other social information conveyed through dynamic facial cues such as changes in eye-gaze direction. Recent work in our laboratory has focused on using functional magnetic resonance imaging (fMRI) in adults to map the neural circuitry subserving the visual analysis of others' actions and the intentions underlying these actions. In these studies, the superior temporal sulcus (STS) region has been continually implicated in processing shifts in eye gaze. Further, these studies have indicated that STS activity is modulated by the context within which eye-gaze shifts occur, suggesting that this region is involved in social perception via its role in the analysis of the intentions of observed actions. Still, no studies have investigated the neural circuitry supporting eye-gaze processing in children. We used event-related fMRI to examine brain activity in 7- to 10-year-old healthy children observing an animated virtual actor who shifted her eyes towards either a target object or empty space. Consistent with prior studies in adults, the STS, middle temporal gyros, and inferior parietal lobule were sensitive to the intentions underlying the stimulus character's eye movements. These findings suggest that the neural circuitry underlying the processing of eye gaze and the detection of intentions conveyed through shifts in eye gaze in children are similar to that found previously in adults. We discuss these findings and potential implications for mapping the neurodevelopment of the social cognition and social perception abnormalities characteristic of autism. (c) 2005 Elsevier Inc. All rights reserved.
C1 Duke Univ, Med Ctr, Duke UNC Brain Imaging & Anal Ctr, Durham, NC 27710 USA.
Univ N Carolina, Sch Med, Dept Psychiat, Chapel Hill, NC 27514 USA.
Univ N Carolina, Dept Psychol, Chapel Hill, NC 27514 USA.
Vet Affairs Med Ctr, Dept Vet Affairs, Durham, NC 27705 USA.
RP Pelphrey, KA (reprint author), Duke Univ, Med Ctr, Duke UNC Brain Imaging & Anal Ctr, POB 3918, Durham, NC 27710 USA.
EM kevin.pelphrey@duke.edu
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NR 30
TC 72
Z9 72
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 1053-8119
J9 NEUROIMAGE
JI Neuroimage
PD AUG 1
PY 2005
VL 27
IS 1
BP 247
EP 252
DI 10.1016/j.neuroimage.2005.03.027
PG 6
WC Neurosciences; Neuroimaging; Radiology, Nuclear Medicine & Medical
Imaging
SC Neurosciences & Neurology; Radiology, Nuclear Medicine & Medical Imaging
GA 948FK
UT WOS:000230701200025
PM 16023041
ER
PT J
AU Berta, S
Park, MS
Meltzer, HS
Amar, AP
Apuzzo, MLJ
Levy, KM
Levy, ML
AF Berta, S
Park, MS
Meltzer, HS
Amar, AP
Apuzzo, MLJ
Levy, KM
Levy, ML
TI Vagus nerve stimulation therapy in patients with autism spectrum
disorder: Results from the vagus nerve stimulation therapy patient
outcome registry
SO NEUROSURGERY
LA English
DT Meeting Abstract
CT 55th Annual Meeting of the Congress-of-Neurological-Surgeons
CY OCT 08-13, 2005
CL Boston, MA
SP Congress Neurol Surg
NR 0
TC 1
Z9 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3261 USA
SN 0148-396X
J9 NEUROSURGERY
JI Neurosurgery
PD AUG
PY 2005
VL 57
IS 2
MA 862
BP 417
EP 418
PG 2
WC Clinical Neurology; Surgery
SC Neurosciences & Neurology; Surgery
GA 953WD
UT WOS:000231111200112
ER
PT J
AU Herbert, MR
Ziegler, DA
AF Herbert, MR
Ziegler, DA
TI Volumetric neuroirnaging and low-dose early-life exposures: Loose
coupling of pathogenesis-brain-behavior links
SO NEUROTOXICOLOGY
LA English
DT Article; Proceedings Paper
CT 21st International Neurotoxicology Conference
CY FEB 10-14, 2004
CL Honolulu, HI
DE brain morphometry; developmental disorder; autism; toxicology; scaling;
network
ID DEVELOPMENTAL LANGUAGE DISORDER; CEREBRAL WHITE-MATTER; TOPOGRAPHIC
PARCELLATION; AUTISM; MRI; IMPAIRMENT; CHILDREN; PRINCIPLES; CORTEX;
TIME
AB The interface of developmental neuroimaging with developmental neurotoxicology can, broadly speaking, address two complementary concerns. The first is to study the impact (of specific exposures (in brain development. The second is to study known neurobehavioral disorders with an eye to discerning toxicological contributions to pathogenesis. Pathogenesis targets brain based upon physical properties (receptors, growth factors, etc.) while behavior is modulated by regional and neural systems alterations. The distribution of pathogenesis-brain relationships overlaps only partially with that of brain-behavior relationships. The goal of this paper is to highlight methodological issues involved in designing and interpreting volumetric neuroimaging studies in the light of this loose coupling. (c) 2005 Elsevier Inc. All rights reserved.
C1 Harvard Univ, Sch Med, Massachusetts Gen Hosp, Ctr Morphometr Anal, Charlestown, MA 02129 USA.
MIT, Cambridge, MA 02139 USA.
RP Herbert, MR (reprint author), Harvard Univ, Sch Med, Massachusetts Gen Hosp, Ctr Morphometr Anal, 149 13th St,Room 6012, Charlestown, MA 02129 USA.
EM mherbert1@partners.org
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NR 35
TC 6
Z9 6
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0161-813X
J9 NEUROTOXICOLOGY
JI Neurotoxicology
PD AUG
PY 2005
VL 26
IS 4
BP 565
EP 572
DI 10.1016/j.neuro.2005.01.002
PG 8
WC Neurosciences; Pharmacology & Pharmacy; Toxicology
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Toxicology
GA 961VH
UT WOS:000231689400009
PM 16112322
ER
PT J
AU Kurita, H
Koyama, T
Osada, H
AF Kurita, H
Koyama, T
Osada, H
TI Autism-Spectrum Quotient-Japanese version and its short forms for
screening normally intelligent persons with pervasive developmental
disorders
SO PSYCHIATRY AND CLINICAL NEUROSCIENCES
LA English
DT Article
DE Autism Spectrum Quotient (AQ); high-functioning pervasive developmental
disorders; psychometric property; questionnaire; screening
ID CHILDHOOD AUTISM; RATING-SCALE; FUNCTIONING AUTISM; ASPERGERS-SYNDROME;
TOKYO VERSION; PREVALENCE; CHILDREN; CARS; AGE
AB A Japanese version of the Autism Spectrum Quotient (AQ), AQ-J was administered to 25 normally intelligent high-functioning pervasive developmental disorder (HPDD) patients (mean age, 24.2 years; 24 male, one female) and 215 controls (mean age, 30.4 years; 86 male, 129 female) randomly selected from the general population. The AQ-J had satisfactory internal consistency reliability (Cronbach's alpha > 0.70 in the two groups), test-retest reliability, and discriminant validity [i.e. the AQ-J score was significantly higher in the HPDD (mean, 29.6) than controls (mean, 22.2)]. At a cut-off of 26, the AQ-J had satisfactory sensitivity, specificity, and negative predictive value, but it had low positive predictive value (0.24) possibly due to the facts that the 25 mild HPDD patients scored lower and the controls scored higher on the AQ-J than British counterparts on the AQ. The AQ-J-21 (consisting of 21 items significantly associated with HPDD diagnosis) and the AQ-J-10 (consisting of 10 of the 21 items with an effect size > 0.17) had higher, although not satisfactory, positive predictive values of 0.35 and 0.46 at cut-offs of 12 and 7, respectively, than the AQ-J. The AQ-J and two short forms are useful not to predict but to rule out mild HPDD, the most difficult part of HPDD to be distinguished from non-PDD conditions, in persons scoring under the cut-offs and to consider professionals' examination of HPDD in persons scoring over them, because their negative predictive values were satisfactory.
C1 Zenkoku Ryoiku Sodan Ctr, Shinjuku Ku, Tokyo 1620051, Japan.
Univ Tokyo, Grad Sch Med, Dept Mental Hlth, Tokyo, Japan.
Ishinomaki Senshu Univ, Fac Law, Tokyo, Japan.
RP Kurita, H (reprint author), Zenkoku Ryoiku Sodan Ctr, Shinjuku Ku, 2-2-8 Nishiwaseda, Tokyo 1620051, Japan.
EM hkurita@mvf.biglobe.ne.jp
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Yeargin-Allsopp M, 2003, JAMA-J AM MED ASSOC, V289, P49, DOI 10.1001/jama.289.1.49
NR 19
TC 46
Z9 46
PU BLACKWELL PUBLISHING
PI OXFORD
PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND
SN 1323-1316
J9 PSYCHIAT CLIN NEUROS
JI Psychiatry Clin. Neurosci.
PD AUG
PY 2005
VL 59
IS 4
BP 490
EP 496
DI 10.1111/j.1440-1819.2005.01403.x
PG 7
WC Clinical Neurology; Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA 946LS
UT WOS:000230574300017
PM 16048456
ER
PT J
AU Poltorak, M
Leach, M
Fairhead, J
Cassell, J
AF Poltorak, M
Leach, M
Fairhead, J
Cassell, J
TI 'MMR talk' and vaccination choices: An ethnographic study in Brighton
SO SOCIAL SCIENCE & MEDICINE
LA English
DT Article
DE MMR; vaccination; immunisation; choice; risk; United Kingdom
ID RUBELLA VACCINE; IMMUNIZATION; CHILDREN; MEASLES; MUMPS; RESISTANCE;
ENGLAND; PARENTS; AUTISM
AB In the context of the high-profile controversy that has unfolded in the UK around the measles, mumps and rubella (MMR) vaccine and its possible adverse effects, this paper explores how parents in Brighton, southern England, are thinking about MMR for their own children. Research focusing on parents' engagement with MMR has been dominated by analysis of the proximate influences on their choices, and in particular scientific and media information, which have led health policy to focus on information and education campaigns. This paper reports ethnographic work including narratives by mothers in Brighton. Our work questions such reasoning in showing how wider personal and social issues shape parents' immunisation actions. The narratives by mothers show how practices around MMR are shaped by personal histories, by birth experiences and related feelings of control, by family health histories, by their readings of their child's health and particular strengths and vulnerabilities, by particular engagements with health services, by processes building or undermining confidence, and by friendships and conversations with others, which are themselves shaped by wider social differences and transformations. Although many see vaccination as a personal decision which must respond to the particularities of a child's immune system, 'MMR talk', which affirms these conceptualisations, has become a social phenomenon in itself. These perspectives suggest ways in which people's engagements with MMR reflect wider changes in their relations with science and the state. (c) 2005 Elsevier Ltd. All rights reserved.
C1 Univ Sussex, Dept Anthropol, Brighton BN1 9RH, E Sussex, England.
Univ Sussex, Inst Dev Studies, Brighton BN1 9RE, E Sussex, England.
RP Leach, M (reprint author), Univ Sussex, Dept Anthropol, Brighton BN1 9RH, E Sussex, England.
EM M.S.Poltorak@sussex.ac.uk; m.leach@ids.ac.uk; J.R.Fairhead@sussex.ac.uk;
j.cassell@pcps.ucl.ac.uk
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NR 46
TC 40
Z9 40
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0277-9536
J9 SOC SCI MED
JI Soc. Sci. Med.
PD AUG
PY 2005
VL 61
IS 3
BP 709
EP 719
DI 10.1016/j.socscimed.2004.12.014
PG 11
WC Public, Environmental & Occupational Health; Social Sciences, Biomedical
SC Public, Environmental & Occupational Health; Biomedical Social Sciences
GA 933UW
UT WOS:000229659400018
PM 15899328
ER
PT J
AU Fatemi, SH
Pearce, DA
Brooks, AI
Sidwell, RW
AF Fatemi, SH
Pearce, DA
Brooks, AI
Sidwell, RW
TI Prenatal viral infection in mouse causes differential expression of
genes in brains of mouse progeny: A potential animal model for
schizophrenia and autism
SO SYNAPSE
LA English
DT Article
DE human influenza; mouse; brain; autism; schizophrenia; DNA microarray
ID FIBRILLARY ACIDIC PROTEIN; INFLUENZA A/WSN/33 VIRUS;
CENTRAL-NERVOUS-SYSTEM; NECROSIS-FACTOR-ALPHA; PREFRONTAL CORTEX;
NEONATAL MICE; IN-UTERO; REELIN IMMUNOREACTIVITY; INFLAMMATORY
CYTOKINES; MICROARRAY ANALYSIS
AB Schizophrenia and autism are neurodevelopmental disorders with genetic and environmental etiologies. Prenatal viral infection has been associated with both disorders. We investigated the effects of prenatal viral infection on gene regulation in offspring of Balb-c mice using microarray technology. The results showed significant upregulation of 21 genes and downregulation of 18 genes in the affected neonatal brain homogenates spanning gene families affecting cell structure and function, namely, cytosolic chaperone system, HSC70, Bicaudal D, aquaporin 4, carbonic anhydrase 3, glycine receptor, norepinephrine transporter, and myelin basic protein. We also verified the results using QPCR measurements of selected mRNA species. These results show for the first time that prenatal human influenza viral infection on day 9 of pregnancy leads to alterations in a subset of genes in brains of exposed offspring, potentially leading to permanent changes in brain structure and function. (c) 2005 Wiley-Liss, Inc.
C1 Univ Minnesota, Sch Med, Dept Psychiat, Div Neurosci Res, Minneapolis, MN 55455 USA.
Univ Rochester, Sch Med, Ctr Aging & Dev Biol, Dept Biochem & Biophys,Dept Neurol, Rochester, NY USA.
Univ Rochester, Sch Med, Dept Environm Med, Ctr Funct Genom, Rochester, NY USA.
Utah State Univ, Logan, UT 84322 USA.
RP Fatemi, SH (reprint author), Univ Minnesota, Sch Med, Dept Psychiat, Div Neurosci Res, MMC 392,420 Delaware St SE, Minneapolis, MN 55455 USA.
EM fatem002@umn.edu
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NR 95
TC 90
Z9 92
PU WILEY-LISS
PI HOBOKEN
PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 0887-4476
J9 SYNAPSE
JI Synapse
PD AUG
PY 2005
VL 57
IS 2
BP 91
EP 99
DI 10.1002/syn.20162
PG 9
WC Neurosciences
SC Neurosciences & Neurology
GA 938JW
UT WOS:000229996900004
PM 15906383
ER
PT J
AU Allman, JM
Watson, KK
Tetreault, NA
Hakeem, AY
AF Allman, JM
Watson, KK
Tetreault, NA
Hakeem, AY
TI Intuition and autism: a possible role for Von Economo neurons
SO TRENDS IN COGNITIVE SCIENCES
LA English
DT Review
ID ANTERIOR CINGULATE CORTEX; HUMAN BRAIN; ORBITOFRONTAL CORTEX; PREFRONTAL
CORTICES; EMPATHY; LOCALIZATION; UNCERTAINTY; CONNECTIONS; RECEPTORS;
EVOLUTION
AB Von Economo neurons (VENs) are a recently evolved cell type which may be involved in the fast intuitive assessment of complex situations. As such, they could be part of the circuitry supporting human social networks. We propose that the VENs relay an output of fronto-insular and anterior cingulate cortex to the parts of frontal and temporal cortex associated with theory-of-mind, where fast intuitions are melded with slower, deliberative judgments. The VENs emerge mainly after birth and increase in number until age 4 yrs. We propose that in autism spectrum disorders the VENs fail to develop normally, and that this failure might be partially responsible for the associated social disabilities that result from faulty intuition.
C1 CALTECH, Div Biol, Pasadena, CA 91125 USA.
RP Allman, JM (reprint author), CALTECH, Div Biol, MC 216-76, Pasadena, CA 91125 USA.
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NR 51
TC 169
Z9 171
PU ELSEVIER SCIENCE LONDON
PI LONDON
PA 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND
SN 1364-6613
J9 TRENDS COGN SCI
JI TRENDS COGN. SCI.
PD AUG
PY 2005
VL 9
IS 8
BP 367
EP 373
DI 10.1016/j.tics.2005.06.008
PG 7
WC Behavioral Sciences; Neurosciences; Psychology, Experimental
SC Behavioral Sciences; Neurosciences & Neurology; Psychology
GA 957MY
UT WOS:000231375100010
PM 16002323
ER
PT J
AU [Anonymous]
AF [Anonymous]
TI A neuropathological study of autism
SO VIRCHOWS ARCHIV
LA English
DT Meeting Abstract
NR 0
TC 0
Z9 0
PU SPRINGER
PI NEW YORK
PA 233 SPRING STREET, NEW YORK, NY 10013 USA
SN 0945-6317
J9 VIRCHOWS ARCH
JI Virchows Arch.
PD AUG
PY 2005
VL 447
IS 2
BP 550
EP 550
PG 1
WC Pathology
SC Pathology
GA 971FN
UT WOS:000232369701257
ER
PT J
AU Morrice, P
AF Morrice, P
TI Autism as metaphor
SO NEW YORK TIMES BOOK REVIEW
LA English
DT Article
NR 0
TC 1
Z9 1
PU NEW YORK TIMES
PI NEW YORK
PA 229 W 43RD ST, NEW YORK, NY 10036-3959 USA
SN 0028-7806
J9 NY TIMES BK REV
JI N. Y. Times Book Rev.
PD JUL 31
PY 2005
BP 23
EP 23
PG 1
WC Humanities, Multidisciplinary
SC Arts & Humanities - Other Topics
GA 948RQ
UT WOS:000230733800037
ER
PT J
AU Fliers, EA
Franke, B
Buitelaar, JK
AF Fliers, EA
Franke, B
Buitelaar, JK
TI Hereditary factors in attention deficit hyperactivity disorder
SO NEDERLANDS TIJDSCHRIFT VOOR GENEESKUNDE
LA Dutch
DT Article
ID DEFICIT/HYPERACTIVITY DISORDER; ADHD; LINKAGE; SCAN; ENDOPHENOTYPE;
METAANALYSIS; ASSOCIATION; GENOTYPE; GENETICS; CHILDREN
AB Hereditary factors in attention deficit hyperactivity disorder - Attention deficit hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by concentration problems, hyperactivity and impulsivity. - Disturbances in dopamine and/or noradrenalin neurotransmission are probably the underlying pathophysiological mechanisms of ADHD. - Around 80% of variants of the phenotype can be ascribed to hereditary factors. There are various chromosomal loci containing ADHD genes. They partially overlap the loci found in linkage studies on dyslexia and autism. It seems likely that a number of genetic variants, each with a small effect size, in combination with gene-environment interactions predispose to ADHD. - There is a high degree of phenotypical heterogeneity among people with ADHD. Finding endophenotypes may improve the power of genetic studies. Endophenotypes are specific expressions of the underlying pathophysiology, intermediate between gene and phenotype. Neuro-imaging studies in children with ADHD have indicated abnormalities in frontostriatal, temporal and cerebellar volume. Unaffected brothers and sisters show the same cerebral abnormalities, but not the cerebellar abnormalities. These brain abnormalities together with specific neuropsychological features could be ADHD endophenotypes.
C1 Univ Med Cent St Radboud, Aft Psychiat, Nijmegen, Netherlands.
RIAGG Rijnmond Zuid Jeugd, NL-3083 BD Rotterdam, Netherlands.
RP Fliers, EA (reprint author), Univ Med Cent St Radboud, Aft Psychiat, Nijmegen, Netherlands.
RI Franke, Barbara/D-4836-2009; Buitelaar, Jan/E-4584-2012
OI Franke, Barbara/0000-0003-4375-6572; Buitelaar, Jan/0000-0001-8288-7757
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(APA) APA, 2000, DIAGN STAT MAN MENT
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NR 23
TC 2
Z9 2
PU BOHN STAFLEU VAN LOGHUM BV
PI HOUTEN
PA POSTBUS 246, 3990 GA HOUTEN, NETHERLANDS
SN 0028-2162
J9 NED TIJDSCHR GENEES
JI Ned. Tijdschr. Geneeskd.
PD JUL 30
PY 2005
VL 149
IS 31
BP 1726
EP 1729
PG 4
GA 959BC
UT WOS:000231490900004
PM 16114287
ER
PT J
AU Day, SM
Strauss, DJ
Shavelle, RM
Reynolds, RJ
AF Day, SM
Strauss, DJ
Shavelle, RM
Reynolds, RJ
TI Causes of death in remote symptomatic epilepsy
SO NEUROLOGY
LA English
DT Article
ID TRAUMATIC BRAIN-INJURY; CAUSE-SPECIFIC MORTALITY; RISK-FACTORS;
CEREBRAL-PALSY; CHILDREN; SEIZURES; POPULATION; SURVIVAL; SUICIDE;
PEOPLE
AB Objective: To determine the causes of death of individuals with developmental disabilities that occur more frequently among those with remote symptomatic epilepsy (i.e., epilepsy occurring in persons with developmental delay or identified brain lesions) than for those without. Methods: The authors compared causes of mortality in persons with (n = 10,030) and without (n = 96,163) history of epilepsy in a California population of persons with mild developmental disabilities, 1988 to 2002. Subjects had traumatic brain injury, cerebral palsy, Down syndrome, autism, or a developmental disability with other or unknown etiology. There were 721,759 person-years of data, with 2,397 deaths. Underlying causes of death were determined from the State of California's official mortality records. Cause-specific death rates and standardized mortality ratios (SMRs) were computed for those with and without epilepsy relative to subjects in the California general population. Comparisons were then made between SMRs of those with and without epilepsy, and CIs on the ratios of SMRs were determined. Results: Death rates for persons with epilepsy were elevated for several causes. The greatest excess was due to seizures (International Classification of Diseases-9 [ICD-9] 345; SMR 53.1, 95% CI 28.0 to 101.0) and convulsions (ICD-9 780.3; SMR 25.2, 95% CI 11.7 to 54.2). Other causes occurring more frequently in those with epilepsy included brain cancer (SMR 5.2, 95% CI 2.2 to 12.1), respiratory diseases (SMR 1.7, 95% CI 1.2 to 2.5), circulatory diseases (SMR 1.3, 95% CI 1.0 to 1.7), and accidents (SMR 2.7, 95% CI 1.9 to 3.7), especially accidental drowning (SMR 12.8, 95% CI 7.0 to 23.2). Conclusions: Remote symptomatic epilepsy is associated with an increased risk of death. Seizures, aspiration pneumonia, and accidental drowning are among the leading contributors.
C1 Life Expectancy Project, San Francisco, CA 94122 USA.
Univ Calif San Francisco, Dept Pediat & Neurol, San Francisco, CA 94143 USA.
RP Day, SM (reprint author), Life Expectancy Project, 1439 17th Ave, San Francisco, CA 94122 USA.
EM Day@LifeExpectancy.com
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NR 35
TC 20
Z9 21
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0028-3878
J9 NEUROLOGY
JI Neurology
PD JUL 26
PY 2005
VL 65
IS 2
BP 216
EP 222
DI 10.1212/01.wnl.0000169018.44950.68
PG 7
WC Clinical Neurology
SC Neurosciences & Neurology
GA 949AD
UT WOS:000230756300008
PM 16043789
ER
PT J
AU Jelliffe-Pawlowski, LL
Shaw, GM
Nelson, V
Harris, JA
AF Jelliffe-Pawlowski, LL
Shaw, GM
Nelson, V
Harris, JA
TI Risks for severe mental retardation occurring in isolation and with
other developmental disabilities
SO AMERICAN JOURNAL OF MEDICAL GENETICS PART A
LA English
DT Article
DE Asperger syndrome; autism; autistic disorder; cerebral palsy; childhood
disintegrative disorder; epidemiology; epilepsy; etiology; mental
retardation; MR; neurodevelopment; PDD-NOS; pervasive developmental
disorder; Rett's disorder
ID UTAH EPIDEMIOLOGIC SURVEY; CEREBRAL-PALSY; 10-YEAR-OLD CHILDREN;
METROPOLITAN ATLANTA; POSTNATAL FACTORS; AUTISM; PREVALENCE; SEIZURES
AB Individual and maternal characteristics as potential risk factors for having severe mental retardation (SMR) occurring with and without cerebral palsy (CP), epilepsy, or a pervasive developmental disorder (PDD) were explored among a cohort of 119,404 children without Down syndrome born in the California Central Valley in 1992 and 1993. Unadjusted and adjusted relative risks (RRs) and their 95% confidence intervals (CIs) based on the Poisson distribution were used to estimate the risks associated with each individual and maternal factor studied for each SMR diagnostic category. The most notable increased risks for SMR occurring in isolation or with CP or epilepsy was for children born low-birth-weight or preterm who were at a substantially increased risk (RRs 2.6-9.9). In contrast, the risk of SMR occurring with a PDD was the greatest among males compared to females (RR = 3.4, 95% CI 1.5, 7.9), Blacks compared to Whites (RR = 5.1,95% CI 1.7,15.5), and Asians compared to Whites (RR = 3.9, 95% CI 1.3, 12.0). Etiologic heterogeneity when SMR occurs with a PDD was suggested. (c) 2005 Wiley-Liss, Inc.
C1 March Dimes Birth Defect Fdn, Calif Birth Defects Monitoring Program, Berkeley, CA USA.
RP Jelliffe-Pawlowski, LL (reprint author), Calif Lead Poisoning Prevent Branch, 1515 Clay St,Suite 1801, Oakland, CA 94612 USA.
EM ljelliff@dhs.ca.gov
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NR 29
TC 2
Z9 2
PU WILEY-LISS
PI HOBOKEN
PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 1552-4825
J9 AM J MED GENET A
JI Am. J. Med. Genet. A
PD JUL 15
PY 2005
VL 136A
IS 2
BP 152
EP 157
DI 10.1002/ajmg.a.30801
PG 6
WC Genetics & Heredity
SC Genetics & Heredity
GA 941QK
UT WOS:000230229100007
PM 15940698
ER
PT J
AU Ye, JH
Zalcman, SS
Tao, L
AF Ye, JH
Zalcman, SS
Tao, L
TI Kainate-activated currents in the ventral tegmental area of neonatal
rats are modulated by interleukin-2
SO BRAIN RESEARCH
LA English
DT Article
DE cytokine; mesolimbic; excitatory amino acid; development; neurotoxicity;
neurogenesis; neurodevelopment; dopamine; schizophrenia; autism
ID DOPAMINE NEURONS; GLYCINE RECEPTORS; BRAIN; CYTOKINE; BEHAVIOR;
EXPRESSION; SURVIVAL; RELEASE; REWARD; NMDA
AB Interleukin (IL)-2 is a potent modulator of neurotransmission and neuronal development in the mesolimbic and mesostriatal systems. It is also implicated in pathologies (including schizophrenia, Parkinson's disease, autism, cognitive disorders) that are linked with abnormalities in these systems. Since the kainate receptor plays an essential role in mesolimbic neuronal development and excitability, we examined the effects of physiologically relevant concentrations of IL-2 on kainate-activated current (I-KA) in voltage-clamped neurons freshly isolated from the ventral tegmental area (VTA) of 3- to 14-day-old rats. IL-2 (0.01 - 10 ng/ml) alone had no effect on membrane conductance. When co-applied with kainate, IL-2 significantly decreased I-KA. IL-2 (2 ng/ml) shifted the kainate concentration-response curve to the right in a parallel manner, significantly increasing the EC50 without changing the maximal I-KA. IL-2 inhibition of I-KA was voltage-dependent, being greater at negative potentials. IL-2 did not alter the reversal potential. These findings suggest that IL-2 potently modulates kainate receptors of developing mesolimbic neurons. We suggest that IL-2 plays a role in the excitability of developing neurons in the mesolimbic system. Inasmuch as increased I-KA, is associated with excitotoxicity, coupled with the present observation that IL-2 inhibits I-KA, we suggest an adaptive role for IL-2 in limiting excitotoxicity in the developing brain. IL-2 might thus be required for normal cell development in the mesolimbic and mesostriatal systems. (c) 2005 Elsevier B.V. All rights reserved.
C1 Univ Med & Dent New Jersey, New Jersey Med Sch, Dept Anesthesiol, Newark, NJ 07103 USA.
Univ Med & Dent New Jersey, New Jersey Med Sch, Dept Pharmacol & Physiol, Newark, NJ 07103 USA.
Univ Med & Dent New Jersey, New Jersey Med Sch, Dept Psychiat, Newark, NJ 07103 USA.
Univ Med & Dent New Jersey, New Jersey Med Sch, Integrat Neurosci Program, Newark, NJ 07103 USA.
RP Ye, JH (reprint author), Univ Med & Dent New Jersey, New Jersey Med Sch, Dept Anesthesiol, 185 S Orange Ave, Newark, NJ 07103 USA.
EM ye@umdnj.edu
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NR 36
TC 7
Z9 8
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0006-8993
J9 BRAIN RES
JI Brain Res.
PD JUL 12
PY 2005
VL 1049
IS 2
BP 227
EP 233
DI 10.1016/j.brainres.2005.05.016
PG 7
WC Neurosciences
SC Neurosciences & Neurology
GA 957BT
UT WOS:000231345000011
PM 15935333
ER
PT J
AU Challoner, A
AF Challoner, A
TI Horizon: Does the MMR jab cause autism? Has the fat lady sung then?
SO BRITISH MEDICAL JOURNAL
LA English
DT Letter
EM oakwoodbank.ac@virgin.net
CR MACAULEY D, 2005, BRIT MED J, V330, P1335, DOI 10.1136/bmj.330.7503.1335
NR 1
TC 0
Z9 0
PU B M J PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 0959-8146
J9 BRIT MED J
JI Br. Med. J.
PD JUL 9
PY 2005
VL 331
IS 7508
BP 111
EP 111
DI 10.1136/bmj.331.7508.111
PG 1
WC Medicine, General & Internal
SC General & Internal Medicine
GA 945XR
UT WOS:000230536800035
PM 16002902
ER
PT J
AU Goodman, NW
AF Goodman, NW
TI Horizon: Does the MMR jab cause autism? We cannot win
SO BRITISH MEDICAL JOURNAL
LA English
DT Letter
ID POWER
C1 Southmead Gen Hosp, Bristol BS10 5NB, Avon, England.
RP Goodman, NW (reprint author), Southmead Gen Hosp, Bristol BS10 5NB, Avon, England.
EM Nev.W.Goodman@bris.ac.uk
CR Draper G, 2005, BRIT MED J, V330, P1290, DOI 10.1136/bmj.330.7503.1290
MACAULEY D, 2005, BRIT MED J, V330, P1335, DOI 10.1136/bmj.330.7503.1335
Watts G, 2005, BRIT MED J, V330, P1293, DOI 10.1136/bmj.330.7503.1293
NR 3
TC 1
Z9 1
PU B M J PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 0959-8146
J9 BRIT MED J
JI Br. Med. J.
PD JUL 9
PY 2005
VL 331
IS 7508
BP 111
EP 111
DI 10.1136/bmj.331.7508.111-a
PG 1
WC Medicine, General & Internal
SC General & Internal Medicine
GA 945XR
UT WOS:000230536800036
PM 16002901
ER
PT J
AU Grady, DL
Harxhi, A
Smith, M
Flodman, P
Spence, MA
Swanson, JM
Moyzis, RK
AF Grady, DL
Harxhi, A
Smith, M
Flodman, P
Spence, MA
Swanson, JM
Moyzis, RK
TI Sequence variants of the DRD4 gene in autism: Further evidence that rare
DRD4 7R haplotypes are ADHD specific
SO AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
LA English
DT Article
DE attention-deficit hyperactivity disorder; dopamine receptor D4; VNTR;
DNA resequencing
ID ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; DEFICIT HYPERACTIVITY
DISORDER; SELECTION; LINKAGE; LOCUS
AB A high prevalence of rare dopamine receptor D4 (DRD4) alleles in children diagnosed with attention-deficit hyperactivity disorder (ADHD) has been reported [Grady et al., 2003]. In this prior study, extensive resequencing/haplotype data of the DRD4 locus was used to suggest that population stratification was not the explanation for the high prevalence of rare alleles. In the current study, DNA resequencing/haplotyping was conducted on 136 DRD4 alleles obtained from autism probands, collected from the same geographic population as the prior ADHD probands (Orange County, CA). A number of studies have suggested that the susceptibility genes underlying these two disorders might partially overlap. Rare DRD4 variants were not uncovered in this autism sample beyond that expected by chance. These results suggest strongly that the high prevalence of rare DRD4 alleles in ADHD probands is due to ascertainment of the sample by diagnosis of ADHD. (c) 2005 Wiley-Liss, Inc.
C1 Univ Calif Irvine, Coll Med, Dept Biol Chem, Irvine, CA 92697 USA.
Univ Calif Irvine, Irvine Med Ctr, Dept Pediat, Orange, CA 92668 USA.
RP Grady, DL (reprint author), Univ Calif Irvine, Coll Med, Dept Biol Chem, Sprague Hall, Irvine, CA 92697 USA.
EM dgrady@uci.edu
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NR 18
TC 22
Z9 23
PU WILEY-LISS
PI HOBOKEN
PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 1552-4841
J9 AM J MED GENET B
JI Am. J. Med. Genet. B
PD JUL 5
PY 2005
VL 136B
IS 1
BP 33
EP 35
DI 10.1002/ajmg.b.30182
PG 3
WC Genetics & Heredity; Psychiatry
SC Genetics & Heredity; Psychiatry
GA 939DN
UT WOS:000230052700005
PM 15892149
ER
PT J
AU Wassink, TH
Piven, J
Vieland, VJ
Jenkins, L
Frantz, R
Bartlett, CW
Goedken, R
Childress, D
Spence, MA
Smith, M
Sheffield, VC
AF Wassink, TH
Piven, J
Vieland, VJ
Jenkins, L
Frantz, R
Bartlett, CW
Goedken, R
Childress, D
Spence, MA
Smith, M
Sheffield, VC
TI Evaluation of the chromosome 2q37.3 gene CENTG2 as an autism
susceptibility gene
SO AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
LA English
DT Article
DE linkage; linkage disequilibrium; autistic disorder; chromosomal
abnormalities
ID ALBRIGHT HEREDITARY OSTEODYSTROPHY; DIAGNOSTIC OBSERVATION SCHEDULE;
NONPARAMETRIC LINKAGE ANALYSIS; CRYPTIC TRANSLOCATION; CLINICAL
PHENOTYPE; TERMINAL DELETION; CANDIDATE REGION; RAT-BRAIN; LONG ARM;
HETEROGENEITY
AB Autism is a highly heritable neurodevelopmental. syndrome with a complex genetic etiology for which no disease genes have yet been definitively identified. We ascertained three subjects with autism spectrum disorders and chromosome 2q37.3 terminal deletions, and refined the deletion breakpoint regions using polymorphism mapping and fluorescence in situ hybridization (FISH) probes. We then genotyped polymorphic markers downstream from the breakpoint region in a sample of autism affected sibling pair families. Both the chromosomal breakpoints and linkage analyses focused our attention on the gene centaurin gamma-2 (CENTG2), an attractive candidate gene based also on its function and pattern of expression. We therefore assessed CENTG2 for its involvement in autism by (1) screening its exons for variants in 199 autistic and 160 non-autistic individuals, and (2) genotyping and assessing intra-genic polymorphisms for linkage and linkage disequilibrium (LD). The exon screen revealed a Ser -> Gly substitution in one proband, an Arg -> Gly substitution in another, and a number of additional variants unique to the autism families. No unique variants were found in the control subjects. The genotyping produced strong evidence for linkage from two intronic polymorphisms, with a maximum two-point HLOD value of 3.96 and a posterior probability of linkage (PPL) of 51%. These results were contradicted, however, by substantially weaker evidence for linkage from multi-point analyses and by no evidence of LD. We conclude, therefore, that 2q37.3 continues to be a region of interest for autism susceptibility, and that CENTG2 is an intriguing candidate gene that merits further scrutiny for its role in autism. (c) 2005 Wiley-Liss, Inc.
C1 Univ Iowa, Carver Coll Med, Dept Psychiat, Iowa City, IA 52242 USA.
Univ N Carolina, Neurodev Disorders Res Ctr, Chapel Hill, NC USA.
Univ N Carolina, Dept Psychiat, Chapel Hill, NC USA.
Univ Iowa, Coll Publ Hlth, Ctr Stat Genet Res, Iowa City, IA USA.
Univ Iowa, Coll Publ Hlth, Program Publ Hlth Genet, Iowa City, IA USA.
Univ Calif Irvine, Dept Pediat, Irvine, CA 92717 USA.
Univ Iowa, Carver Coll Med, Dept Pediat, Iowa City, IA USA.
Univ Iowa, Carver Coll Med, Howard Hughes Med Inst, Iowa City, IA USA.
RP Wassink, TH (reprint author), Univ Iowa, Carver Coll Med, Dept Psychiat, Iowa City, IA 52242 USA.
EM thomas-wassink@uiowa.edu
RI Bartlett, Christopher/B-4958-2009
OI Bartlett, Christopher/0000-0001-7837-6348
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NR 51
TC 37
Z9 40
PU WILEY-LISS
PI HOBOKEN
PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 1552-4841
J9 AM J MED GENET B
JI Am. J. Med. Genet. B
PD JUL 5
PY 2005
VL 136B
IS 1
BP 36
EP 44
DI 10.1002/ajmg.b.30180
PG 9
WC Genetics & Heredity; Psychiatry
SC Genetics & Heredity; Psychiatry
GA 939DN
UT WOS:000230052700006
PM 15892143
ER
PT J
AU Bradley, SL
Dodelzon, K
Sandhu, HK
Philibert, RA
AF Bradley, SL
Dodelzon, K
Sandhu, HK
Philibert, RA
TI Relationship of serotonin transporter gene polymorphisms and haplotypes
to mRNA transcription
SO AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
LA English
DT Article
DE serotonin transporter; polymorphism; transcriptional regulation;
haplotype; lymphoblast
ID PROMOTER POLYMORPHISM; EXPRESSION; DISORDER; PERSONALITY; ASSOCIATION;
POPULATION; GENOTYPE; FAMILIES; TRAITS; REGION
AB The serotonin transporter (5HTT; chromosomal location 17q12) is an important regulator of serotonergic neurotransmission and is the site of action for a number of antidepressant medications. Sequence variation at a VNTR known as the 5HTTLPR, which is 1.4 kb upstream of the translation start of 5HTT, has been associated in some studies with increased vulnerability to depression, neuroticism, and autism. Support for these clinical observations has included laboratory findings that 5HTTLPR variation is associated with changes in 5HTT gene translation. We reexamined these earlier laboratory findings by directly measuring 5HTT mRNA levels and genotyping four loci spanning the 5HTT gene using RNA and DNA prepared from 85 independent lymphoblast cell lines. Using this data, haplotypes were inferred and the resulting single point and haplotypes data analyzed by univariate and regression analyses. Consistent with the original findings, we found a significant effect of the 5HTTLPR on mRNA production. In contrast to previous reports, the effect on 5HTT mRNA production appeared to be mediated through an additive, not dominant, mechanism. Neither genotype nor haplotype at three other 5HTT loci were associated with alterations in mRNA production, although the small number of samples homozygous for the three most common haplotypes limits these findings. We conclude that further examination of the role of 5HTT sequence variation in regulating 5HTT mRNA production is warranted. (c) 2005 Wiley-Liss, Inc.
C1 Univ Iowa, Dept Psychiat & Neurosci Program, Iowa City, IA 52242 USA.
Univ Iowa, Dept Psychiat, Iowa City, IA USA.
RP Philibert, RA (reprint author), Univ Iowa, Dept Psychiat & Neurosci Program, Rm 2-126 MEB Psychiat Res-MEB, Iowa City, IA 52242 USA.
EM robert-philibert@uiowa.edu
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NR 19
TC 72
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PU WILEY-LISS
PI HOBOKEN
PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 1552-4841
J9 AM J MED GENET B
JI Am. J. Med. Genet. B
PD JUL 5
PY 2005
VL 136B
IS 1
BP 58
EP 61
DI 10.1002/ajmg.b.30185
PG 4
WC Genetics & Heredity; Psychiatry
SC Genetics & Heredity; Psychiatry
GA 939DN
UT WOS:000230052700009
PM 15858822
ER
PT J
AU Shu, WG
Cho, JY
Jiang, YH
Zhang, MH
Weisz, D
Elder, GA
Schmeidler, J
De Gasperi, R
Sosa, MAG
Rabidou, D
Santucci, AC
Perl, D
Morrisey, E
Buxbaum, JD
AF Shu, WG
Cho, JY
Jiang, YH
Zhang, MH
Weisz, D
Elder, GA
Schmeidler, J
De Gasperi, R
Sosa, MAG
Rabidou, D
Santucci, AC
Perl, D
Morrisey, E
Buxbaum, JD
TI Altered ultrasonic vocalization in mice with a disruption in the Foxp2
gene
SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF
AMERICA
LA English
DT Article
DE autism; cerebellum; communication; language; speech
ID LANGUAGE DISORDER; SEVERE SPEECH; SUSCEPTIBILITY GENE; AUTISM;
EXPRESSION; BRAIN; IMPAIRMENT; RATS
AB Neurobiology of speech and language has previously been studied in the KE family, in which half of the members have severe impairment in both speech and language. The gene responsible for the phenotype was mapped to chromosome 7q31 and identified as the FOXP2 gene, coding for a transcription factor containing a polyglutamine tract and a forkhead DNA-binding domain. Because of linkage studies implicating 7q31 in autism, where language impairment is a component of the disorder, and in specific language impairment, FOXP2 has also been considered as a potential susceptibility locus for the language deficits in autism and/or specific language impairment. In this study, we characterized mice with a disruption in the murine Foxp2 gene. Disruption of both copies of the Foxp2 gene caused severe motor impairment, premature death, and an absence of ultrasonic vocalizations that are elicited when pups are removed from their mothers. Disruption of a single copy of the gene led to modest developmental delay but a significant alteration in ultrasonic vocalization in response to such separation. Learning and memory appear normal in the heterozygous animals. Cerebellar abnormalities were observed in mice with disruptions in Foxp2, with Purkinje cells particularly affected. our findings support a role for Foxp2 in cerebellar development and in a developmental process that subsumes social communication functions in diverse organisms.
C1 CUNY Mt Sinai Sch Med, Lab Mol Neuropsychiat, New York, NY 10029 USA.
CUNY Mt Sinai Sch Med, Dept Psychiat, New York, NY 10029 USA.
CUNY Mt Sinai Sch Med, Dept Neurosci, New York, NY 10029 USA.
CUNY Mt Sinai Sch Med, Dept Neurosurg, New York, NY 10029 USA.
CUNY Mt Sinai Sch Med, Dept Neurol, New York, NY 10029 USA.
CUNY Mt Sinai Sch Med, Dept Otolaryngol, New York, NY 10029 USA.
CUNY Mt Sinai Sch Med, Dept Pathol, New York, NY 10029 USA.
CUNY Mt Sinai Sch Med, Dept Geriatr & Adult Dev, New York, NY 10029 USA.
CUNY Mt Sinai Sch Med, Dept Biomath Sci, New York, NY 10029 USA.
Manhattanville Coll, Dept Psychol, Purchase, NY 10577 USA.
RP Buxbaum, JD (reprint author), CUNY Mt Sinai Sch Med, Lab Mol Neuropsychiat, 1 Gustave L Levy Pl, New York, NY 10029 USA.
EM joseph.buxbaum@mssm.edu
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NR 30
TC 164
Z9 171
PU NATL ACAD SCIENCES
PI WASHINGTON
PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA
SN 0027-8424
J9 P NATL ACAD SCI USA
JI Proc. Natl. Acad. Sci. U. S. A.
PD JUL 5
PY 2005
VL 102
IS 27
BP 9643
EP 9648
DI 10.1073/pnas.0503739102
PG 6
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 944DN
UT WOS:000230406000037
PM 15983371
ER
PT J
AU Willatt, L
Cox, J
Barber, J
Cabanas, ED
Collins, A
Donnai, D
FitzPatrick, DR
Maher, E
Martin, H
Parnau, J
Pindar, L
Ramsay, J
Shaw-Smith, C
Sistermans, EA
Tettenborn, M
Trump, D
de Vries, BBA
Walker, K
Raymond, FL
AF Willatt, L
Cox, J
Barber, J
Cabanas, ED
Collins, A
Donnai, D
FitzPatrick, DR
Maher, E
Martin, H
Parnau, J
Pindar, L
Ramsay, J
Shaw-Smith, C
Sistermans, EA
Tettenborn, M
Trump, D
de Vries, BBA
Walker, K
Raymond, FL
TI 3q29 Microdeletion syndrome: Clinical and molecular characterization of
a new syndrome
SO AMERICAN JOURNAL OF HUMAN GENETICS
LA English
DT Article
ID UNEXPLAINED MENTAL-RETARDATION; CHROMOSOMAL REARRANGEMENTS; DELETIONS;
TELOMERES; MONOSOMY; CHILDREN; PROBES; 1P36
AB We report the identification of six patients with 3q29 microdeletion syndrome. The clinical phenotype is variable despite an almost identical deletion size. The phenotype includes mild- to- moderate mental retardation, with only slightly dysmorphic facial features that are similar in most patients: a long and narrow face, short philtrum, and high nasal bridge. Autism, gait ataxia, chest- wall deformity, and long and tapering fingers were noted in at least two of six patients. Additional features - including microcephaly, cleft lip and palate, horseshoe kidney and hypospadias, ligamentous laxity, recurrent middle ear infections, and abnormal pigmentation - were observed, but each feature was only found once, in a single patient. The microdeletion is similar to 1.5 Mb in length, with molecular boundaries mapping within the same or adjacent bacterial artificial chromosome ( BAC) clones at either end of the deletion in all patients. The deletion encompasses 22 genes, including PAK2 and DLG1, which are autosomal homologues of two known X- linked mental retardation genes, PAK3 and DLG3. The presence of two nearly identical low- copy repeat sequences in BAC clones on each side of the deletion breakpoint suggests that nonallelic homologous recombination is the likely mechanism of disease causation in this syndrome.
C1 Univ Cambridge, Addenbrookes Hosp, Dept Med Genet, Cambridge Inst Med Res, Cambridge CB2 2XY, England.
Salisbury Dist Hosp, Wessex Reg Genet Lab, Salisbury, Wilts, England.
Princess Anne Hosp, Wessex Clin Genet Serv, Southampton, Hants, England.
Univ Manchester, Acad Unit Med Genet, Manchester, Lancs, England.
St Marys Hosp, Reg Genet Serv, Manchester M13 0JH, Lancs, England.
Western Gen Hosp, MRC Human Genet Unit, Edinburgh EH4 2XU, Midlothian, Scotland.
Western Gen Hosp, Lothian Reg Genet Serv, Edinburgh EH4 2XU, Midlothian, Scotland.
Norfolk & Norwich Hosp, Dept Cytogenet, Norwich NR1 3SR, Norfolk, England.
Radboud Univ, Nijmegen Med Ctr, Nijmegen, Netherlands.
Frimley Childrens Ctr, Frimley, England.
RP Raymond, FL (reprint author), Univ Cambridge, Addenbrookes Hosp, Dept Med Genet, Cambridge Inst Med Res, Cambridge CB2 2XY, England.
EM flr24@cam.ac.uk
RI FitzPatrick, David/B-8311-2008; FitzPatrick, David/C-7301-2013;
Dachs-Cabanas, Elisabet/F-7636-2015
OI Dachs-Cabanas, Elisabet/0000-0001-6969-0626
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NR 20
TC 118
Z9 119
PU UNIV CHICAGO PRESS
PI CHICAGO
PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA
SN 0002-9297
J9 AM J HUM GENET
JI Am. J. Hum. Genet.
PD JUL
PY 2005
VL 77
IS 1
BP 154
EP 160
DI 10.1086/431653
PG 7
WC Genetics & Heredity
SC Genetics & Heredity
GA 935PP
UT WOS:000229794500016
PM 15918153
ER
PT J
AU Smith, SA
Press, B
Koenig, KP
Kinnealey, M
AF Smith, SA
Press, B
Koenig, KP
Kinnealey, M
TI Effects of sensory integration intervention on self-stimulating and
self-injurious behaviors
SO AMERICAN JOURNAL OF OCCUPATIONAL THERAPY
LA English
DT Article
ID MENTAL-RETARDATION; REDUCTION; THERAPY; DISABILITIES; AUTISM
AB This study compared the effects of occupational therapy, using a sensory integration (SI) approach and a control intervention of tabletop activities, on the frequency of self-stimulating behaviors in seven children 8-19 years of age with pervasive developmental delay and mental retardation. Daily 15-min videotape segments of the subjects were recorded before, immediately after, and 1 hour after either SI or control interventions performed during alternating weeks for 4 weeks. Each 15-min video segment was evaluated by investigators to determine the frequency of self-stimulating behaviors, The results indicate that self-stimulating behaviors were significantly reduced by 11% one hour after SI intervention in comparison with the tabletop activity intervention (p = 0.02). There was no change immediately following SI or tabletop interventions. Daily ratings of self-stimulating behavior frequency by classroom teachers using a 5-point scale correlated significantly with the frequency counts taken by the investigators (r = 0.32, p < 0.001). These results suggest that the sensory integration approach is effective in reducing self-stimulating behaviors, which interfere with the ability to participate in more functional activities.
C1 Temple Univ, Dept Occupat Therapy, Neuromuscular Funct Lab, Philadelphia, PA 19140 USA.
Woods Serv, Langhorne, PA USA.
RP Smith, SA (reprint author), Temple Univ, Dept Occupat Therapy, Neuromuscular Funct Lab, 3307 N Broad St, Philadelphia, PA 19140 USA.
EM sinclair.smith@temple.edu
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NR 32
TC 25
Z9 26
PU AMER OCCUPATIONAL THERAPY ASSOC, INC
PI BETHESDA
PA 4720 MONTGOMERY LANE, BETHESDA, MD 20814-3425 USA
SN 0272-9490
J9 AM J OCCUP THER
JI Am. J. Occup. Ther.
PD JUL-AUG
PY 2005
VL 59
IS 4
BP 418
EP 425
PG 8
WC Rehabilitation
SC Rehabilitation
GA 945VP
UT WOS:000230530700007
PM 16124208
ER
PT J
AU Mccracken, JT
AF Mccracken, JT
CA Ped Psychophar Autism Network
TI Risperidone treatment of autistic disorder: Longer-term benefits and
blinded discontinuation after 6 months
SO AMERICAN JOURNAL OF PSYCHIATRY
LA English
DT Article
ID PERVASIVE DEVELOPMENTAL DISORDERS; DIAGNOSTIC INTERVIEW; BEHAVIORAL
SYMPTOMS; CLINICAL-TRIALS; YOUNG-CHILDREN; RUPP AUTISM; ADOLESCENTS;
INDIVIDUALS; HALOPERIDOL; EFFICACY
AB Objective: Risperidone is effective for short-term treatment of aggression, temper outbursts, and self-injurious behavior in children with autism. Because these behaviors may be chronic, there is a need to establish the efficacy and safety of longer-term treatment with this agent.
Method: The authors conducted a multisite, two-part study of risperidone in children ages 5 to 17 years with autism accompanied by severe tantrums, aggression, and/or self-injurious behavior who showed a positive response in an earlier 8-week trial. Part I consisted of 4-month open-label treatment with risperidone, starting at the established optimal dose; part II was an 8-week randomized, double-blind, placebo-substitution study of risperidone withdrawal. Primary outcome measures were the Aberrant Behavior Checklist irritability subscale and the Clinical Global Impression improvement scale.
Results: Part I included 63 children. The mean risperidone dose was 1.96 mg/day at entry and remained stable over 16 weeks of open treatment. The change on the Aberrant Behavior Checklist irritability subscale was small and clinically insignificant. Reasons for discontinuation of part I included loss of efficacy (N = 5) and adverse effects (N = 1). The subjects gained an average of 5.1 kg. Part II included 32 patients. The relapse rates were 62.5% for gradual placebo substitution and 12.5% for continued risperidone; this difference was statistically significant.
Conclusions: Risperidone showed persistent efficacy and good tolerability for intermediate-length treatment of children with autism characterized by tantrums, aggression, and/or self-injurious behavior. Discontinuation after 6 months was associated with a rapid return of disruptive and aggressive behavior in most subjects.
C1 Univ Calif Los Angeles, Inst Neuropsychiat, Los Angeles, CA 90024 USA.
Indiana Univ, Bloomington, IN 47405 USA.
Yale Univ, New Haven, CT 06520 USA.
Columbia Univ, New York, NY 10027 USA.
RP Mccracken, JT (reprint author), Univ Calif Los Angeles, Inst Neuropsychiat, 760 Westwood Plaza, Los Angeles, CA 90024 USA.
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NR 28
TC 111
Z9 111
PU AMER PSYCHIATRIC PUBLISHING, INC
PI ARLINGTON
PA 1000 WILSON BOULEVARD, STE 1825, ARLINGTON, VA 22209-3901 USA
SN 0002-953X
J9 AM J PSYCHIAT
JI Am. J. Psychiat.
PD JUL
PY 2005
VL 162
IS 7
BP 1361
EP 1369
PG 9
WC Psychiatry
SC Psychiatry
GA 941EB
UT WOS:000230196500019
ER
PT J
AU Barbaresi, WJ
Katusic, SK
Colligan, RC
Weaver, AL
Jacobsen, SJ
AF Barbaresi, WJ
Katusic, SK
Colligan, RC
Weaver, AL
Jacobsen, SJ
TI Incidence of autism - In reply
SO ARCHIVES OF PEDIATRICS & ADOLESCENT MEDICINE
LA English
DT Editorial Material
ID VACCINE
C1 Mayo Clin & Mayo Fdn, Div Dev & Behav Pediat, Rochester, MN 55905 USA.
RP Barbaresi, WJ (reprint author), Mayo Clin & Mayo Fdn, Div Dev & Behav Pediat, 200 1st St SW, Rochester, MN 55905 USA.
EM barbaresi.william@mayo.edu
CR Halsey NA, 1998, PEDIATRICS, V101, P129
Barbaresi WJ, 2005, ARCH PEDIAT ADOL MED, V159, P37, DOI 10.1001/archpedi.159.1.37
Katz SL, 1997, PEDIATRICS, V100, P891, DOI 10.1542/peds.100.5.891
Plotkin SA, 2004, VACCINES, P707
NR 4
TC 0
Z9 0
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 515 N STATE ST, CHICAGO, IL 60610 USA
SN 1072-4710
J9 ARCH PEDIAT ADOL MED
JI Arch. Pediatr. Adolesc. Med.
PD JUL
PY 2005
VL 159
IS 7
BP 691
EP 692
DI 10.1001/archpedi.159.7.691-b
PG 2
WC Pediatrics
SC Pediatrics
GA 941QP
UT WOS:000230229600021
ER
PT J
AU Fischer, F
AF Fischer, F
TI Incidence of autism
SO ARCHIVES OF PEDIATRICS & ADOLESCENT MEDICINE
LA English
DT Editorial Material
RP Fischer, F (reprint author), 111 W Stone Dr,Suite 200, Kingsport, TN 37660 USA.
EM ffischer@chartertn.net
CR *ACIP, MEASL PUMPS RUB VACC
Barbaresi WJ, 2005, ARCH PEDIAT ADOL MED, V159, P37, DOI 10.1001/archpedi.159.1.37
NR 2
TC 3
Z9 3
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 515 N STATE ST, CHICAGO, IL 60610 USA
SN 1072-4710
J9 ARCH PEDIAT ADOL MED
JI Arch. Pediatr. Adolesc. Med.
PD JUL
PY 2005
VL 159
IS 7
BP 691
EP 691
DI 10.1001/archpedi.159.7.691-a
PG 1
WC Pediatrics
SC Pediatrics
GA 941QP
UT WOS:000230229600020
PM 15997008
ER
PT J
AU Russell, E
Sofronoff, K
AF Russell, E
Sofronoff, K
TI Anxiety and social worries in children with Asperger syndrome
SO AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY
LA English
DT Article
DE anxiety; Asperger syndrome; parent reports
ID PERVASIVE DEVELOPMENTAL DISORDERS; AUTISM; LANGUAGE; SYMPTOMS
AB Objective: The current study examined anxiety and social worries in a group of children with Asperger syndrome (AS).
Method: Sixty-five children with AS were compared with a clinically anxious sample and a normative sample using parent and child reports.
Results: Comparisons between clinically anxious children and children with AS showed similar scores on overall anxiety and on six anxiety subscales using child reports. Parent reports revealed higher ratings of overall anxiety and described children with AS experiencing more obsessive-compulsive symptoms and physical injury fears than clinically anxious children.
Conclusions: Children with AS without a diagnosis of anxiety, present with more anxiety symptoms than a normal population and with a different profile than a clinically anxious population. Study limitations are identified and considerations for future research presented.
C1 Univ Queensland, Sch Psychol, Brisbane, Qld, Australia.
RP Sofronoff, K (reprint author), Univ Queensland, Sch Psychol, Brisbane, Qld, Australia.
EM kate@psy.uq.edu.au
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NR 30
TC 78
Z9 80
PU BLACKWELL PUBLISHING ASIA
PI CARLTON
PA 54 UNIVERSITY ST, P O BOX 378, CARLTON, VICTORIA 3053, AUSTRALIA
SN 0004-8674
J9 AUST NZ J PSYCHIAT
JI Aust. N. Z. J. Psych.
PD JUL
PY 2005
VL 39
IS 7
BP 633
EP 638
DI 10.1080/j.1440-1614.2005.01637.x
PG 6
WC Psychiatry
SC Psychiatry
GA 939FG
UT WOS:000230057200015
PM 15996146
ER
PT J
AU Blanc, R
Adrien, JL
Roux, S
Barthelemy, C
AF Blanc, R
Adrien, JL
Roux, S
Barthelemy, C
TI Dysregulation of pretend play and communication development in children
with autism
SO AUTISM
LA English
DT Article
DE autism; communication development; pretend play; regulation of activity
ID SYMBOLIC PLAY; CHILDHOOD PSYCHOSES; DOWN-SYNDROME; INTERVENTION;
GENERATIVITY; COMPETENCE; IMITATION; BEHAVIOR; DEFICITS; SKILLS
AB We hypothesized that the difficulties of the child with autism originate from disorders of organization and regulation of actions according to environmental changes. Autism impoverishes general mental representation skills, which are the basis of symbolic play and the development of communication. Twenty-one children with autism were compared with 14 children with global intellectual impairment and 15 matched typically developing children, on both regulation of play activities and communication development. Regulation of play was very disordered in children with autism, with breaking off, dissociation and instability of actions. However, in directed play their actions were more structured and corresponded to a better developmental level. In addition, dysregulation was associated with delayed, heterogeneous development of communication skills. The results of this study are in line with our hypotheses and emphasize the role of symbolic play in differential diagnosis and the value of therapies based on regulation processes and symbolic play.
C1 CHU Bretonneau, Serv Explorat Fonct & Neurophysiol Pedopsychiat, F-37000 Tours, France.
CHU Bretonneau, INSERM, F-37000 Tours, France.
Univ Paris 05, Boulogne, Billancourt, France.
RP Blanc, R (reprint author), CHU Bretonneau, Serv Explorat Fonct & Neurophysiol Pedopsychiat, 2 Blvd Tonnelle, F-37000 Tours, France.
EM r.blanc@chu-tours.fr
CR Adrien J. L., 1996, AUTISME JEUNE ENFANT
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NR 63
TC 14
Z9 16
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1362-3613
J9 AUTISM
JI Autism
PD JUL
PY 2005
VL 9
IS 3
BP 229
EP 245
DI 10.1177/1362361305053253
PG 17
WC Psychology, Developmental
SC Psychology
GA 945LZ
UT WOS:000230505300002
PM 15937039
ER
PT J
AU Honey, E
Hastings, RP
McConachie, H
AF Honey, E
Hastings, RP
McConachie, H
TI Use of the questionnaire on resources and stress (QRS-F) with parents of
young children with autism
SO AUTISM
LA English
DT Article
DE autism; coping; parents; preschool children; Questionnaire on Resources
and Stress; social support
ID FAMILY STRESS; BEHAVIOR CHECKLIST; SOCIAL SUPPORT; MENTAL-HEALTH;
MOTHERS; INTERVENTION; FATHERS; INDIVIDUALS; PROFILES
AB The Questionnaire on Resources and Stress (Friedrich, short form: QRS-F) has been used widely with parents of children with disabilities. However, its psychometric properties in parents of young children with autism have not been established. Here, 174 mothers and 43 fathers of children under 6 years with autism spectrum disorder were studied by two independent research teams. Each parent completed a 31-item version of the QRS-F. Factor analysis of the mothers' scores on these items failed to identify an expected two- or three-factor structure. Thus, the properties of a total stress score were explored. Ana-lyses revealed evidence of good reliability, and expected associations with social support, coping and autism severity These analyses lend preliminary support to the convergent validity of the scale. Overall, the data support the use of a total stress score from the 31-item version of the QRS-F in research with parents of young children with autism.
C1 Univ Newcastle Upon Tyne, Sch Clin Med Sci, Newcastle Upon Tyne NE2 4AE, Tyne & Wear, England.
Univ Wales Coll Cardiff, Cardiff CF1 3NS, S Glam, Wales.
RP McConachie, H (reprint author), Univ Newcastle Upon Tyne, Sch Clin Med Sci, 1-2 Claremont Terrace, Newcastle Upon Tyne NE2 4AE, Tyne & Wear, England.
EM h.r.mcconachie@ncl.ac.uk
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NR 32
TC 19
Z9 19
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1362-3613
J9 AUTISM
JI Autism
PD JUL
PY 2005
VL 9
IS 3
BP 246
EP 255
DI 10.1177/1362361305053256
PG 10
WC Psychology, Developmental
SC Psychology
GA 945LZ
UT WOS:000230505300003
PM 15937040
ER
PT J
AU Ratliff-Schaub, K
Carey, T
Reeves, GD
Rogers, MAM
AF Ratliff-Schaub, K
Carey, T
Reeves, GD
Rogers, MAM
TI Randomized controlled trial of transdermal secretin on behaviour of
children with autism
SO AUTISM
LA English
DT Article
ID PLACEBO-CONTROLLED TRIAL; PERVASIVE DEVELOPMENTAL DISORDER;
DOUBLE-BLIND; PORCINE SECRETIN
AB Previous trials of secretin for the treatment of autism have utilized a single or double dose administered intravenously. This is a report of a double-blind, randomized, controlled crossover trial of transdermally applied secretin in 1 S children diagnosed with autism or pervasive developmental delay. Secretin or placebo was applied daily, in ointment form, to the backs of the children in randomized, successive 4 week periods with an intermediate 6 week washout period. Behavioral outcomes were measured by parents and teachers using the Autism Treatment Evaluation Checklist. Overall, there were no statistically significant differences in speech, sociability, sensory, and health scores for treatment versus placebo periods. In addition, there were no differences in such scores for children with a history of diarrhea. Severity of autism was significantly greater at baseline in children receiving concomitant medications. Improvement in speech was found during the treatment phase of the trial (p = 0.0479 for secretin versus placebo) only in children not using other medications.
C1 Childrens Hosp, Div Dev Behav Pediat, Columbus, OH 43205 USA.
Med Coll Ohio, Toledo, OH 43699 USA.
Eastern Michigan Univ, Ypsilanti, MI 48197 USA.
Univ Michigan, Ann Arbor, MI 48109 USA.
RP Ratliff-Schaub, K (reprint author), Childrens Hosp, Div Dev Behav Pediat, 555 18th St, Columbus, OH 43205 USA.
CR American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th
Carey T, 2002, J AUTISM DEV DISORD, V32, P161, DOI 10.1023/A:1015493412224
Chez MG, 2000, J AUTISM DEV DISORD, V30, P87, DOI 10.1023/A:1005443119324
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NR 15
TC 7
Z9 7
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1362-3613
J9 AUTISM
JI Autism
PD JUL
PY 2005
VL 9
IS 3
BP 256
EP 265
DI 10.1177/1362361305053257
PG 10
WC Psychology, Developmental
SC Psychology
GA 945LZ
UT WOS:000230505300004
PM 15937041
ER
PT J
AU Stokes, MA
Kaur, A
AF Stokes, MA
Kaur, A
TI High-functioning autism and sexuality - A parental perspective
SO AUTISM
LA English
DT Article
DE autism; high-functioning; autism; sex education; sexual behaviour
ID ASPERGER-SYNDROME; ADOLESCENTS; ATTITUDES; INDIVIDUALS; KNOWLEDGE;
DISORDER; ADULTS
AB Few studies have compared sexual behaviours among adolescents with high-functioning autism (HFA) and typical populations, and indicated whether specialized education is required. We hypothesized that adolescents with HFA would (1) display poorer social behaviours; (2) engage in fewer behaviours related to privacy and have poorer knowledge regarding privacy issues; (3) have less sex education; and (4) display more inappropriate sexual behaviours; and that (5) parental concerns would be greater for the HFA sample. Parents of typical adolescents (n = 50) and adolescents with HFA (n = 23) were surveyed with a Sexual Behaviour Scale (SBS) developed by the authors, with domains corresponding to the hypotheses. The HFA and typical groups were found to be significantly different on all five domains. However, following covariation with age and level of social behaviour, it was found that only parental concerns about their child distinguished between typical adolescents and those with HFA. Specialized sex education programmes with a social interaction emphasis should be considered for this group.
C1 Deakin Univ, Sch Psychol, Burwood, Vic 3125, Australia.
RP Stokes, MA (reprint author), Deakin Univ, Sch Psychol, 221 Burwood Hwy, Burwood, Vic 3125, Australia.
EM stokes@deakin.edu.au
CR American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th
Attwood T., 1998, ASPERGERS SYNDROME G
ATTWOOD T, 2002, IN WORLD AUT C MELB
Clements J., 2000, BEHAV CONCERNS AUTIS
Cohen J., 2003, APPL MULTIPLE REGRES
Eisenmajer R, 1998, J AUTISM DEV DISORD, V28, P527, DOI 10.1023/A:1026004212375
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Haracopos D., 1992, SEXUALITY AUTISM DAN
HELLEMANS H, 2002, IN WORLD AUT C MELB
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TABACHNIK BG, 2001, USING MULTIVARIATE
Volkmar F., 1987, HDB AUTISM PERVASIVE, P41
NR 29
TC 34
Z9 34
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1362-3613
J9 AUTISM
JI Autism
PD JUL
PY 2005
VL 9
IS 3
BP 266
EP 289
DI 10.1177/1362361305053258
PG 24
WC Psychology, Developmental
SC Psychology
GA 945LZ
UT WOS:000230505300005
PM 15937042
ER
PT J
AU Fido, A
Al-Saad, S
AF Fido, A
Al-Saad, S
TI Toxic trace elements in the hair of children with autism
SO AUTISM
LA English
DT Article
DE autism; hair analysis; toxic metals
ID LEAD-EXPOSURE; BEHAVIOR; CANCER
AB Excess or deficiency of natural trace elements has been implicated in the etiology of autism. This study explores whether concentration levels of toxic metals in the hair of children with autism significantly differ from those of age- and sex-matched healthy controls. in-hair concentration levels of antimony, uranium, arsenic, beryllium, mercury, cadmium, lead and aluminum from 40 boys with autism and 40 healthy boys were determined by Perkin-Elmer mass spectrometry. The children with autism had significantly (p < 0.001) higher in-hair concentration levels of lead, mercury and uranium. There was no significant difference between the two groups in the other five toxic elements. The ratio between nutritional elements and toxic metals among children with autism was within the normal range. The possible sources of the toxic metals are discussed. Such testing is informative but at present the practical implications in terms of diagnosis and clinical management are limited.
C1 Kuwait Univ, Fac Med, Dept Psychiat, Safat 13110, Kuwait.
Kuwait Autism Ctr, Safat, Kuwait.
RP Fido, A (reprint author), Kuwait Univ, Fac Med, Dept Psychiat, POB 24923, Safat 13110, Kuwait.
EM fido@HSC.EDU.KW
CR Abiaka CD, 2001, CANCER DETECT PREV, V25, P245
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Wasserman GA, 2000, J PEDIATR-US, V137, P555, DOI 10.1067/mpd.2000.109111
NR 24
TC 61
Z9 62
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1362-3613
J9 AUTISM
JI Autism
PD JUL
PY 2005
VL 9
IS 3
BP 290
EP 298
DI 10.1177/1362361305053255
PG 9
WC Psychology, Developmental
SC Psychology
GA 945LZ
UT WOS:000230505300006
PM 15937043
ER
PT J
AU Fleischmann, A
AF Fleischmann, A
TI The hero's story and autism - Grounded theory study of websites for
parents of children with autism
SO AUTISM
LA English
DT Article
DE autism; hero; parents; qualitative research; websites
ID QUALITATIVE RESEARCH; STRESS; FAMILY; INDIVIDUALS; DISORDERS; SPECTRUM
AB Thirty-three websites self-published on the Internet by parents of children with autism were examined using grounded theory. The process that the parents underwent closely follows an outline drawn by Catford and Ray to describe the hero's development. Following diagnosis, parents of children with autism underwent a period of readjustment after which each of the parents described in the study prepared himself or herself for action. In the aftermath, the parents viewed themselves and their offspring in a positive light. At the close of the life narrative, all said they had come to terms with their child's present circumstances and were prepared to help other parents in coping with their children. Our study suggests that the Internet allows stressed parents of children with autism to forge ties among themselves and extricate themselves from their isolation.
C1 Achva Coll Educ, Res Unit, IL-79800 Shikmim, Israel.
Achva Coll Educ, Dept Special Educ, IL-79800 Shikmim, Israel.
RP Fleischmann, A (reprint author), Achva Coll Educ, Res Unit, IL-79800 Shikmim, Israel.
EM amosf@macam.ac.il
CR Abelson A. G., 1999, FOCUS AUTISM OTHER D, V14, P96, DOI 10.1177/108835769901400204
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Gray David E., 1992, Australia and New Zealand Journal of Developmental Disabilities, V18, P83
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NR 48
TC 14
Z9 14
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1362-3613
J9 AUTISM
JI Autism
PD JUL
PY 2005
VL 9
IS 3
BP 299
EP 316
DI 10.1177/1362361305054410
PG 18
WC Psychology, Developmental
SC Psychology
GA 945LZ
UT WOS:000230505300007
PM 15937044
ER
PT J
AU Grant, CM
Boucher, J
Riggs, KJ
Grayson, A
AF Grant, CM
Boucher, J
Riggs, KJ
Grayson, A
TI Moral understanding in children with autism
SO AUTISM
LA English
DT Article
DE autism; mental state understanding; moral understanding
ID HIGH-FUNCTIONING CHILDREN; OTHERS; GENERATIVITY; PLAY
AB Children with autism were compared with control groups on their ability to make moral judgements. Participants were presented with pairs of vignettes in which actions were either deliberate or accidental and caused injury to a person or damage to property. Participants were asked to judge which protagonist was the naughtier and to verbally justify this judgement. Results showed that the children with autism were as likely as controls to judge culpability on the basis of motive, and to judge injury to persons as more culpable than damage to property. Children with autism also offered some appropriate verbal justifications for their judgments although most justifications were of poor quality and reiterated the story. Results a-re discussed in terms of theory of mind and the possible role of deficits in complex reasoning and executive functions.
C1 Univ Sheffield, Sheffield S10 2TN, S Yorkshire, England.
Univ Warwick, Coventry CV4 7AL, W Midlands, England.
London Guildhall Univ, London, England.
Nottingham Trent Univ, Nottingham, England.
RP Grant, CM (reprint author), Univ Birmingham, Clin Psychol, Birmingham B15 2TT, W Midlands, England.
EM cmg242@bham.ac.uk
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NR 31
TC 41
Z9 41
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1362-3613
J9 AUTISM
JI Autism
PD JUL
PY 2005
VL 9
IS 3
BP 317
EP 331
DI 10.1177/1362361305055418
PG 15
WC Psychology, Developmental
SC Psychology
GA 945LZ
UT WOS:000230505300008
PM 15937045
ER
PT J
AU Abel, JS
Russell, PSS
AF Abel, JS
Russell, PSS
TI Communication and symbolic behaviour deficits in children with autism:
are they related to other autistic domains?
SO AUTISM
LA English
DT Letter
C1 Christian Med Coll & Hosp, Vellore, Tamil Nadu, India.
RP Abel, JS (reprint author), Christian Med Coll & Hosp, Vellore, Tamil Nadu, India.
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Wetherby AM, 2002, J SPEECH LANG HEAR R, V45, P1202, DOI 10.1044/1092-4388(2002/097)
NR 5
TC 0
Z9 0
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1362-3613
J9 AUTISM
JI Autism
PD JUL
PY 2005
VL 9
IS 3
BP 333
EP 334
PG 2
WC Psychology, Developmental
SC Psychology
GA 945LZ
UT WOS:000230505300010
PM 16138419
ER
PT J
AU Guldberg, K
AF Guldberg, K
TI Autism and early years practice. A guide for early years professionals,
teachers and parents
SO AUTISM
LA English
DT Book Review
C1 Univ Birmingham, Sch Educ, Birmingham B15 2TT, W Midlands, England.
RP Guldberg, K (reprint author), Univ Birmingham, Sch Educ, Birmingham B15 2TT, W Midlands, England.
CR WALL K, 2004, AUTISM EARLY YEARS G
NR 1
TC 0
Z9 0
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1362-3613
J9 AUTISM
JI Autism
PD JUL
PY 2005
VL 9
IS 3
BP 335
EP 336
DI 10.1177/1362361305053262
PG 2
WC Psychology, Developmental
SC Psychology
GA 945LZ
UT WOS:000230505300011
ER
PT J
AU Redcay, E
Courchesne, E
AF Redcay, E
Courchesne, E
TI When is the brain enlarged in autism? A meta-analysis of all brain size
reports
SO BIOLOGICAL PSYCHIATRY
LA English
DT Article
DE brain growth; structural imaging; MRI; post-mortem; head circumference;
autism
ID HEAD CIRCUMFERENCE; INTERNEURON DEVELOPMENT; SPECTRUM DISORDERS;
CEREBRAL-CORTEX; CHILDREN; VOLUME; MRI; AGE; WEIGHT; ADULTS
AB Background: Multiple studies have reported increased brain size in autism, while others have found no difference from normal. These conflicting results may be due to a lack of accounting for age-related changes in brain enlargements, use of small of small sample sizes, or differences in data acquisition methods.
Methods: Reports of autism head circumference (HC), magnetic resonance imaging (MRI), and post-mortem brain weight (BW) that met specific criteria were identified and analyzed, Percent difference from normal values (%Diff) and standardized mean differences (SMD) were calculated to compare brain size across studies and measurement methods. Curve fitting, analysis of variance and heterogeneity analyses were applied to assay the effects the age and measurement hype on, reported brain size in autism,
Results: A fitted curve of HC and MRI %Diff values from 15 studies revealed a largely consistent of brain size changes. Specifically, brain size in autism was slightly reduced at birth, dramatically increased within the first year of life, but when plateaued so that by adulthood the majority of cases within norma range. Analysis of variance of MRI and post-mortem %Diff values by age group (young child, older child, adult) and measurement .
C1 Univ Calif San Diego, Dept Psychol, San Diego, CA 92103 USA.
Univ Calif San Diego, Dept Neurosci, San Diego, CA 92103 USA.
Childrens Hosp, Res Ctr, San Diego, CA USA.
RP Redcay, E (reprint author), 8110 La Jolla Shores Dr,Suite 201, La Jolla, CA 92037 USA.
EM elizabeth@brain.ucsd.edu
RI Redcay, Elizabeth/C-7818-2011
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NR 66
TC 253
Z9 259
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD JUL 1
PY 2005
VL 58
IS 1
BP 1
EP 9
DI 10.1016/j.biopsych.2005.03.026
PG 9
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA 942CI
UT WOS:000230260100001
PM 15935993
ER
PT J
AU Myers, KM
Goulet, M
Rusche, J
Boismenu, R
Davis, M
AF Myers, KM
Goulet, M
Rusche, J
Boismenu, R
Davis, M
TI Partial reversal of phencyclidine-induced impairment of prepulse
inhibition by secretin
SO BIOLOGICAL PSYCHIATRY
LA English
DT Article
DE antipsychotic; attention; autism; schizophrenia; sensorimotor gating;
startle
ID PERVASIVE DEVELOPMENTAL DISORDER; CORTICOTROPIN-RELEASING-FACTOR;
SENSORIMOTOR GATING DEFICITS; ACOUSTIC STARTLE RESPONSE;
PLACEBO-CONTROLLED TRIAL; RAT-BRAIN; INTRAVENOUS SECRETIN;
ANTIPSYCHOTIC-DRUGS; POTENTIATED STARTLE; CONDITIONED FEAR
AB Background: Secretin is a "gut-brain" peptide whose neural function is as yet poorly understood. Several clinical studies have reported modestly increased social interaction in autistic children following intravenous secretin administration. Very recently secretin also was administered to schizophrenic patients and found to increase social interaction in some individuals.
Methods: In light of this finding, we assessed the ability of secretin to reverse phencyclidine- (PCP) induced impairment in prepulse inhibition (PPI), a leading animal model of sensorimotor gating deficits in schizophrenia.
Results: Similar to atypical antipsychotics, secretin (1, 3, 10, 30, and 100 mu g/kg) partially and dose-dependently reversed the PCP-induced deficit in PPI without significantly affecting baseline startle when administered intraperitoneally (IP) 10 minutes following IP administration of PCP (3 mg/kg).
Conclusions: This finding may be relevant to observations of antipsychotic efficacy of secretin in schizophrenic patients as well as our previous report that systemically administered secretin is capable of modulating conditioned fear, even at quite low doses.
C1 Emory Univ, Ctr Behav Neurosci, Atlanta, GA 30329 USA.
Emory Univ, Dept Psychiat & Behav Sci, Atlanta, GA 30329 USA.
Repligen Corp, Waltham, MA USA.
RP Davis, M (reprint author), Emory Univ, Ctr Behav Neurosci, Yerkes Neurosci Bldg,Room 5200,954 Gatewood Rd NE, Atlanta, GA 30329 USA.
EM mdavis4@emory.edu
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NR 61
TC 7
Z9 7
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD JUL 1
PY 2005
VL 58
IS 1
BP 67
EP 73
DI 10.1016/j.biopsych.2005.03.023
PG 7
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA 942CI
UT WOS:000230260100010
PM 15992525
ER
PT J
AU Wu, SP
Jia, MX
Ruan, Y
Liu, J
Guo, YQ
Shuang, M
Gong, XH
Zhang, YB
Yang, XL
Zhang, D
AF Wu, SP
Jia, MX
Ruan, Y
Liu, J
Guo, YQ
Shuang, M
Gong, XH
Zhang, YB
Yang, XL
Zhang, D
TI Positive association of the oxytocin receptor gene (OXTR) with autism in
the Chinese Han population
SO BIOLOGICAL PSYCHIATRY
LA English
DT Article
DE autism; OXTR; single nucleotide polymorphism; family-based association
test; hapoltype; linkage disequilibrium
ID SOCIAL-BEHAVIOR; TRANSIENT EXPRESSION; ANIMAL-MODELS; RAT-BRAIN;
VASOPRESSIN; NEUROPEPTIDES; ORGANIZATION; APPEARANCE; DISORDERS; INFANT
AB Background: Previous research has suggested that the social impairments exhibited by individuals with autism are associated with changes in plasme oxytocin (OT) levels. The physiologic effects of oxytocin are mediated through its specific receptors (OTRs), and numerous studies have implicated OTRs in the regulation of social cognition and behavior, Animal models and linkage data from genome screens indicate that the oxytocin receptor gene (OXTR) is an excellent candidate for research concerning psychiatric disorders, particularly those involving social impairments, such as autism,
Methods: We genotyped four single nucleotide polymorpbisms (SNTs) located within the OXTR gene of 195 Chinese Han autism trios, using polymerase chain reaction-restriction fragment length polymorphism analysis.
Results: The family-based association test (FBAT) revealed a significant genetic association between autism and two of the SNPs tested (rs2254298 A: Z = 2.287 p =.0222, rs53576A: Z = 2,573, p =.0101). When haplotypes were constructed with two, three, and four markers, the haplotype-specific FBAT revealed that a number of haplotypes, particularly those involving rs53576, were significantly associated with autism. Furthermore, haplotypes constructed with all markers showed a significant excess transmission for the specific and global haplotype analyses (p =.0020 and.0289, respectively).
Conclusions: These data suggest an involvement of OXTR in the susceptibility to autism, and replication is important.
C1 Peking Univ, Inst Mental Hlth, Beijing 100083, Peoples R China.
RP Zhang, D (reprint author), Peking Univ, Inst Mental Hlth, Beijing 100083, Peoples R China.
EM yangxl@public.fhnet.cn.net; daizhang@bjmu.edu.cn
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NR 31
TC 246
Z9 256
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD JUL 1
PY 2005
VL 58
IS 1
BP 74
EP 77
DI 10.1016/j.biopsych.2005.03.013
PG 4
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA 942CI
UT WOS:000230260100011
PM 15992526
ER
PT J
AU Golla, H
Thier, P
Haarmeier, T
AF Golla, H
Thier, P
Haarmeier, T
TI Disturbed overt but normal covert shifts of attention in adult
cerebellar patients
SO BRAIN
LA English
DT Article
DE cerebellum; saccades; attention; dysmetria; psychophysics
ID EYE-MOVEMENTS; SACCADIC DYSMETRIA; INFANTILE-AUTISM; LESIONS; DEFICITS;
MICROSTIMULATION; ABNORMALITY; INVOLVEMENT; COGNITION; CHILDREN
AB In an attempt to provide a common denominator for cognitive deficits observed in cerebellar patients, it has been suggested that they might be secondary to impaired control of attention, a 'dysmetria of attention', conceptually analogous to motor dysmetria. Albeit appealing and quite influential, the concept of attentional dysmetria as a consequence of cerebellar disease remains controversial. In an attempt to test this concept in a direct way, we compared the performance of patients with cerebellar disorders to that of normal controls on tasks requiring either overt or covert shifts of spatial attention. In the first experiment, visually guided saccades, i.e. overt shifts of spatial attention, were elicited. In the second experiment, covert shifts of attention were evoked by the need to discriminate the orientation of a Landolt C observed during controlled fixation and presented in the same locations as the saccade targets in the previous experiment. The allocation of attention was assessed by comparing acuity thresholds determined with and without spatial cueing. The patients exhibited dysmetric saccades as reflected by larger absolute position errors or a higher number of corrective saccades compared to controls. In contrast, the ability to shift attention covertly was unimpaired in the patients, as indicated by a robust improvement in visual acuity induced by spatial cueing which did not differ from the one observed in the controls and which was independent of the range of SOAs (stimulus onset asynchronies) tested. Finally, the individual amount of saccadic dysmetria did not correlate with the individual performance in the covert attentional paradigm. In summary, we conclude that the contributions of the cerebellum to attention are confined to overt manifestations based on goal-directed eye movements.
C1 Univ Tubingen, Dept Cognit Neurol, Tubingen, Germany.
Univ Tubingen, Hertie Inst Clin Brain Res, Dept Gen Neurol, Tubingen, Germany.
RP Golla, H (reprint author), Klinikum Schnarrenberg, Hertie Inst Clin Brain Res, Dept Cognit Neurol, Hoppe Seyler Str 3, D-72076 Tubingen, Germany.
EM heidrun.golla@uni-tuebingen.de
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NR 41
TC 30
Z9 30
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0006-8950
J9 BRAIN
JI Brain
PD JUL
PY 2005
VL 128
BP 1525
EP 1535
DI 10.1093/brain/awh523
PN 7
PG 11
WC Clinical Neurology; Neurosciences
SC Neurosciences & Neurology
GA 941HB
UT WOS:000230204800007
PM 15872017
ER
PT J
AU Dziobek, I
Rogers, K
Fleck, S
Hassenstab, J
Gold, S
Wolf, OT
Convit, A
AF Dziobek, I
Rogers, K
Fleck, S
Hassenstab, J
Gold, S
Wolf, OT
Convit, A
TI In search of "master mindreaders": Are psychics superior in reading the
language of the eyes?
SO BRAIN AND COGNITION
LA English
DT Article
DE theory of mind; empathy; social cognition; mental states; mindreading;
psychic; expertise; brain-behavior
ID HIGH-FUNCTIONING AUTISM; ASPERGER-SYNDROME; NORMAL ADULTS; MIND;
SCHIZOPHRENIA; BEHAVIOR; CHILDREN; EMPATHY; BRAIN
AB Much of the effort to understand the brain substrate of theory of mind and empathy has involved the study of individuals with deficits in that domain, such as those on the autism spectrum. Studying individuals with presumed superior abilities in picking up social signals may yield important additional information. We predicted that psychic readers may have superior abilities and tested this by contrasting a group of 22 professional psychic readers with matched controls on a measure of theory of mind ("Reading the Mind in the Eyes" test) and a multidimensional measure of empathy [Interpersonal Reactivity Index (IRI)]. Although psychic readers were not superior in reading the language of the eyes, they were shown to have more cognitive empathy, as measured with the "Fantasy" subscale of the IRI. We discuss the merits of research involving "experts" in social cognition and propose other possible groups of "master mindreaders." (c) 2004 Elsevier Inc. All rights reserved.
C1 NYU, Sch Med, Dept Psychiat, Ctr Brain Hlth, New York, NY 10016 USA.
Max Planck Inst Neurol Res, Cologne, Germany.
Univ Dusseldorf, Inst Expt Psychol, D-4000 Dusseldorf, Germany.
Nathan S Kline Inst Psychiat Res, Orangeburg, NY 10962 USA.
RP Dziobek, I (reprint author), NYU, Sch Med, Dept Psychiat, Ctr Brain Hlth, New York, NY 10016 USA.
EM dziobi01@med.nyu.edu
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TC 5
Z9 5
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0278-2626
J9 BRAIN COGNITION
JI Brain Cogn.
PD JUL
PY 2005
VL 58
IS 2
BP 240
EP 244
DI 10.1016/j.bandc.2004.12.002
PG 5
WC Neurosciences; Psychology, Experimental
SC Neurosciences & Neurology; Psychology
GA 935AK
UT WOS:000229750900012
PM 15919556
ER
PT J
AU Shastry, BS
AF Shastry, BS
TI Recent advances in the genetics of autism spectrum disorders - A
minireview
SO BRITISH JOURNAL OF DEVELOPMENTAL DISABILITIES
LA English
DT Review
ID PERVASIVE DEVELOPMENTAL DISORDERS; SUSCEPTIBILITY LOCI; NEUROANATOMICAL
OBSERVATIONS; SEROTONIN SYNTHESIS; GENOMEWIDE SCREEN; CHILDHOOD AUTISM;
INFANTILE-AUTISM; GENOMIC SCREEN; BRAIN; CHILDREN
C1 Oakland Univ, Dept Biol Sci, Rochester, MI 48309 USA.
RP Shastry, BS (reprint author), Oakland Univ, Dept Biol Sci, Rochester, MI 48309 USA.
EM shastry@oakland.edu
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NR 90
TC 3
Z9 3
PU BRITISH SOC DEVELOPMENTAL DISABILITIES
PI STRATFORD-UPON-AVON
PA C/O SEFA PUBL LTD, 4 GREAT WILLIAM ST, STRATFORD-UPON-AVON CV37 6RY,
WARWICK, ENGLAND
SN 0969-7950
J9 BRIT J DEV DISABIL
JI Br. J. Dev. Disabil.
PD JUL
PY 2005
VL 51
IS 101
BP 129
EP 142
PN 2
PG 14
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA 993VH
UT WOS:000233983000002
ER
PT J
AU Boddaert, N
Bartheletmy, C
Poline, JB
Samson, Y
Brunelle, F
Zilbovicius, M
AF Boddaert, N
Bartheletmy, C
Poline, JB
Samson, Y
Brunelle, F
Zilbovicius, M
TI Autism: functional brain mapping of exceptional calendar capacity
SO BRITISH JOURNAL OF PSYCHIATRY
LA English
DT Article
ID MENTAL CALCULATION; IDIOT SAVANT; MEMORY
AB Background Autistic savants' are individuals with autism who have extraordinary skills. Brain mechanisms underlying such capacities are still unknown.
Aims To map the exceptional calendar capacity of a man with primary autism.
Method Positron emission tomography was used to map brain activity in a man who is able to associate a day of the week with the corresponding calendar date.
Results During the calendar task, the left hippocampus, the left frontal cortex and the left middle temporal lobe were activated.
Conclusions The cerebral circuit involved in this man's prodigious calendar skill is similar to that normally involved in memory retrieval tasks. These results suggest that the prodigious capacities may be sustained by memory processing.
C1 Serv Hosp Frederic Joliot, DRM, DSV, CEA,INSERM, F-91406 Orsay, France.
Hop Necker Enfants Malad, Serv Radiol Pediat, Paris, France.
CHU Bretonneau, INSERM, Unite 316, Tours, France.
Grp Hosp Pitie Salpetriere, Serv Urgences Cerebro Vasc, Paris, France.
RP Zilbovicius, M (reprint author), Serv Hosp Frederic Joliot, DRM, DSV, CEA,INSERM, 4 Pl Gen Leclerc,ERM 0205, F-91406 Orsay, France.
EM zilbo@shfj.cea.fr
CR American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th
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NR 17
TC 16
Z9 18
PU ROYAL COLLEGE OF PSYCHIATRISTS
PI LONDON
PA BRITISH JOURNAL OF PSYCHIATRY 17 BELGRAVE SQUARE, LONDON SW1X 8PG,
ENGLAND
SN 0007-1250
J9 BRIT J PSYCHIAT
JI Br. J. Psychiatry
PD JUL
PY 2005
VL 187
BP 83
EP 86
DI 10.1192/bjp.187.1.83
PG 4
WC Psychiatry
SC Psychiatry
GA 945ZT
UT WOS:000230542300014
PM 15994576
ER
PT J
AU Garcia-Heras, J
Kilani, RA
Martin, RA
Lamp, S
AF Garcia-Heras, J
Kilani, RA
Martin, RA
Lamp, S
TI A deletion of proximal 20p inherited from a normal mosaic carrier mother
in a newborn with panhypopituitarism and craniofacial dysmorphism
SO CLINICAL DYSMORPHOLOGY
LA English
DT Article
DE deletion 20p11.2; maternal origin; maternal 20p deletion mosaicism
ID GERM-LINE MOSAICISM; ALAGILLE-SYNDROME; MICRODELETION; DISEASE
AB We describe a newborn male with a constitutional deletion of proximal chromosome 20p involving band p11.2. The phenotype included panhypopituitarism, craniofacial dysmorphism, a small phallus with a semi bifid scrotum, and bilateral widely separated first and second toes. The deletion was inherited from his mother, a mosaic carrier of the same deletion in peripheral lymphocytes. The only other similar case with a deletion of 20p11.22-p11.23 exhibited a phenotype that also included abnormal neural development (autism, craniofacial dysmorphism, and Hirschsprung disease). Our patient expands the spectrum of neurodevelopmental abnormalities associated with haploinsufficiency of band 20p11.2, and is the second deletion of 20p inherited from a normal mosaic carrier mother.
C1 Washington Univ, Sch Med, Dept Pediat, Div Genet & Genom Med, St Louis, MO 63110 USA.
Washington Univ, Sch Med, Dept Pediat, Div Newborn Med, St Louis, MO 63110 USA.
RP Garcia-Heras, J (reprint author), Washington Univ, Sch Med, Dept Pediat, Div Genet & Genom Med, 4942 Parkview Pl,Campus Box 8116, St Louis, MO 63110 USA.
EM Garcia-Heras_J@kids.wustl.edu
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NR 14
TC 6
Z9 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0962-8827
J9 CLIN DYSMORPHOL
JI Clin. Dysmorphol.
PD JUL
PY 2005
VL 14
IS 3
BP 137
EP 140
DI 10.1097/00019605-200507000-00006
PG 4
WC Genetics & Heredity
SC Genetics & Heredity
GA 950PC
UT WOS:000230868400006
PM 15930903
ER
PT J
AU Damico, JS
Nelson, RL
AF Damico, JS
Nelson, RL
TI Interpreting problematic behavior: Systematic compensatory adaptations
as emergent phenomena in autism
SO CLINICAL LINGUISTICS & PHONETICS
LA English
DT Article
DE pragmatic disability; emergence; compensatory adaptation; autism;
conversation analysis
ID IMMEDIATE ECHOLALIA; QUALITATIVE METHODS; APHASIA RESEARCH;
CONVERSATION; CHILDREN; STRATEGIES; LANGUAGE; IMPAIRMENT; COMPETENCE
AB Based upon an emergent account of pragmatic ability and disability, this article provides theoretical and empirical support for a conceptually deeper understanding of some systematic behaviors that have served as diagnostic indices in communicatively impaired populations. Specifically, by employing conversation analysis, several examples of problematic behaviors in autism are analysed as a specific type of compensatory adaptation. Theoretical and clinical implications are discussed.
C1 Univ Louisiana, Lafayette, LA 70504 USA.
Univ Texas, El Paso, TX 79968 USA.
RP Damico, JS (reprint author), Univ Louisiana, POB 43170, Lafayette, LA 70504 USA.
EM jsdamico@louisiana.edu
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NR 52
TC 5
Z9 5
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 0269-9206
J9 CLIN LINGUIST PHONET
JI Clin. Linguist. Phon.
PD JUL-AUG
PY 2005
VL 19
IS 5
BP 405
EP 417
DI 10.1080/02699200400027163
PG 13
WC Audiology & Speech-Language Pathology; Linguistics; Rehabilitation
SC Audiology & Speech-Language Pathology; Linguistics; Rehabilitation
GA 935EB
UT WOS:000229761200005
PM 16019784
ER
PT J
AU Kasai, K
Hashimoto, O
Kawakubo, Y
Yumoto, M
Kamio, S
Itoh, K
Koshida, I
Iwanami, A
Nakagome, K
Fukuda, M
Yamasue, H
Yamada, H
Abe, O
Aoki, S
Kato, N
AF Kasai, K
Hashimoto, O
Kawakubo, Y
Yumoto, M
Kamio, S
Itoh, K
Koshida, I
Iwanami, A
Nakagome, K
Fukuda, M
Yamasue, H
Yamada, H
Abe, O
Aoki, S
Kato, N
TI Delayed automatic detection of change in speech sounds in adults with
autism: A magnetoencephalographic study
SO CLINICAL NEUROPHYSIOLOGY
LA English
DT Article
DE autism; magnetoencephalography (MEG); mismatch negativity (MMN);
phoneme; speech sound; tone; vowel
ID MISMATCH NEGATIVITY; CHILDHOOD AUTISM; POTENTIAL EVIDENCE;
AUDITORY-CORTEX; RATING-SCALE; HUMAN BRAIN; CHILDREN; PERCEPTION;
SCHIZOPHRENIA; STIMULI
AB Objective: Autism is a form of pervasive developmental disorder in which dysfunction in interpersonal relationships and communication is fundamental. This study evaluated neurophysiological abnormalities at the basic level of language processing, i.e. automatic change detection of speech and non-speech sounds, using magnetoencephalographic recording of mismatch response elicited by change in vowels and tones.
Methods: The auditory magnetic mismatch field (MMF) was evaluated in 9 adults with autism and 19 control subjects using whole-head magnetoencephalography. The MMF in response to the duration change of a pure tone or vowel /a/ and that in response to across-phoneme change between vowels /a/ and /o/, were recorded.
Results: The groups were not significantly different in MMF power under any conditions. However, the autism group showed a left-biased latency prolongation of the MMF particularly under the across-phoneme change condition, and this latency delay was significantly associated with greater symptom severity.
Conclusions: These results suggest that adults with autism are associated with delayed processing for automatic change detection of speech sounds. These electrophysiological abnormalities at the earliest level of information processing may contribute to the basis for language deficits observed in autism.
Significance: These results provide the first evidence for delayed latency of phonetic MMF in adults with autism. (c) 2005 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.
C1 Univ Tokyo, Grad Sch Med, Dept Neuropsychiat, Bunkyo Ku, Tokyo 1138655, Japan.
Nagoya Univ, Grad Sch Med, Nagoya, Aichi, Japan.
Univ Tokyo, Grad Sch Med, Dept Lab Med, Tokyo, Japan.
Univ Tokyo, Grad Sch Med, Dept Cognit & Speech Sci, Tokyo, Japan.
Tokyo Univ Technol, Sch Bion, Tokyo, Japan.
Aino Univ, Dept Med Technol, Osaka, Japan.
Showa Univ, Sch Med, Dept Psychiat, Tokyo 142, Japan.
Gunma Univ, Grad Sch Med, Dept Psychiat & Human Behav, Gunma, Japan.
Univ Tokyo, Grad Sch Med, Dept Radiol, Tokyo, Japan.
RP Kasai, K (reprint author), Univ Tokyo, Grad Sch Med, Dept Neuropsychiat, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1138655, Japan.
EM kasaik-tky@umin.ac.jp
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TC 28
Z9 29
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
IRELAND
SN 1388-2457
J9 CLIN NEUROPHYSIOL
JI Clin. Neurophysiol.
PD JUL
PY 2005
VL 116
IS 7
BP 1655
EP 1664
DI 10.1016/j.clinph.2005.03.007
PG 10
WC Clinical Neurology; Neurosciences
SC Neurosciences & Neurology
GA 942QL
UT WOS:000230296800022
PM 15899591
ER
PT J
AU Oberman, LM
Hubbard, EM
McCleery, JP
Altschuler, EL
Ramachandran, VS
Pineda, JA
AF Oberman, LM
Hubbard, EM
McCleery, JP
Altschuler, EL
Ramachandran, VS
Pineda, JA
TI EEG evidence for mirror neuron dysfunction in autism spectrum disorders
SO COGNITIVE BRAIN RESEARCH
LA English
DT Article; Proceedings Paper
CT 11th Annual Meeting of the Cognitive-Neuroscience-Society
CY APR, 2004
CL San Francisco, CA
SP Cognitive Neurosci Soc
DE mirror neurons; autism spectrum disorders; EEG; Mu rhythm
ID PREMOTOR CORTEX; MU RHYTHMS; IMITATION; MOTOR; MOVEMENT; MIND; CHILDREN;
LANGUAGE; MOTION; GRASP
AB Autism spectrum disorders (ASD) are largely characterized by deficits in imitation, pragmatic language, theory of mind, and empathy. Previous research has suggested that a dysfunctional mirror neuron system may explain the pathology observed in ASD. Because EEG oscillations in the mu frequency (8-13 Hz) over sensorimotor cortex are thought to reflect mirror neuron activity, one method for testing the integrity of this system is to measure mu responsiveness to actual and observed movement. It has been established that mu power is reduced (mu suppression) in typically developing individuals both when they perform actions and when they observe others performing actions, reflecting an observation/execution system which may play a critical role in the ability to understand and imitate others' behaviors. This study investigated whether individuals with ASD show a dysfunction in this system, given their behavioral impairments in understanding and responding appropriately to others' behaviors. Mu wave suppression was measured in ten high-functioning individuals with ASD and ten age- and gender-matched control subjects while watching videos of (1) a moving hand, (2) a bouncing ball, and (3) visual noise, or (4) moving their own hand. Control subjects showed significant mu suppression to both self and observed hand movement. The ASD group showed significant mu suppression to self-performed hand movements but not to observed hand movements. These results support the hypothesis of a dysfunctional mirror neuron system in high-functioning individuals with ASD. (c) 2005 Elsevier B.V. All rights reserved.
C1 Univ Calif San Diego, Ctr Brain & Cognit, La Jolla, CA 92093 USA.
Univ Calif San Diego, Dept Psychol, La Jolla, CA 92093 USA.
Mt Sinai Sch Med, Dept Rehabil Med, New York, NY 10029 USA.
Univ Calif San Diego, Dept Neurosci, La Jolla, CA 92093 USA.
Univ Calif San Diego, Dept Cognit Sci, La Jolla, CA 92093 USA.
RP Oberman, LM (reprint author), 9500 Gilman Dr, La Jolla, CA 92093 USA.
EM lshenk@psy.ucsd.edu
RI Hubbard, Edward/C-1770-2012
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Altschuler E.L., 1997, 27 ANN M SOC NEUR NE
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NR 54
TC 286
Z9 303
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0926-6410
J9 COGNITIVE BRAIN RES
JI Cognit. Brain Res.
PD JUL
PY 2005
VL 24
IS 2
BP 190
EP 198
DI 10.1016/j.cogbrainres.2005.01.014
PG 9
WC Computer Science, Artificial Intelligence; Neurosciences; Neuroimaging
SC Computer Science; Neurosciences & Neurology
GA 948XA
UT WOS:000230747800002
ER
PT J
AU Maughan, B
Iervolino, AC
Collishaw, S
AF Maughan, B
Iervolino, AC
Collishaw, S
TI Time trends in child and adolescent mental disorders
SO CURRENT OPINION IN PSYCHIATRY
LA English
DT Article
DE adolescence; attention deficit hyperactivity disorder; autism spectrum
disorder; conduct problems; eating disorders; emotional problems; time
trends
ID PERVASIVE DEVELOPMENTAL DISORDERS; DEFICIT HYPERACTIVITY DISORDER;
DELIBERATE SELF-HARM; SUICIDE TRENDS; YOUTH SUICIDE; AUTISM; ENGLAND;
WALES; PSYCHOPATHOLOGY; PATTERNS
AB Purpose of review 1995 saw the publication of a major review of time trends in psychosocial disorders of youth across the second half of the twentieth century. It found evidence for substantial increases in rates of youth crime, alcohol and drug use, depression and suicide in most industrialized countries in the decades following the Second World War, slowing in some instances in the 1980s. Ten years on, we review findings on more recent trends in rates of these and other indicators of child and adolescent mental health.
Recent findings Prevalence estimates for autism spectrum disorders have increased in recent decades, as has public and professional awareness of hyperactivity and attention deficits. Trends in adolescent conduct problems, and in alcohol and drug use, appear to reflect culture-specific influences. Rates of suicide among young males, and self-harm among females have risen in many countries in recent years; trends in emotional disorders are more varied, but there is little evidence for any rise in rates of anorexia nervosa. Although some contributors to these trends have been identified, much remains to be learned about the key risks involved.
Summary Monitoring time trends in child and adolescent mental health is essential for service planning; knowledge of changing trends can also provide important pointers to potential risk factors. Current data sources allow relatively reliable tracking of trends in some areas, but remain severely limited in others. Further research is needed to understand the mechanisms underlying recently identified trends in child and adolescent mental health.
C1 Kings Coll London, Inst Psychiat, MRC, Social Genet & Dev Psychiat Ctr, London SE5 8AF, England.
RP Maughan, B (reprint author), Kings Coll London, Inst Psychiat, MRC, Social Genet & Dev Psychiat Ctr, Box P046, London SE5 8AF, England.
EM b.maughan@iop.kcl.ac.uk
RI turton, miranda/F-4682-2011
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NR 45
TC 39
Z9 39
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0951-7367
J9 CURR OPIN PSYCHIATR
JI Curr. Opin. Psychiatr.
PD JUL
PY 2005
VL 18
IS 4
BP 381
EP 385
DI 10.1097/01.yco.0000172055.25284.f2
PG 5
WC Psychiatry
SC Psychiatry
GA 946NX
UT WOS:000230580200004
PM 16639129
ER
PT J
AU Cummins, A
Piek, JP
Dyck, MJ
AF Cummins, A
Piek, JP
Dyck, MJ
TI Motor coordination, empathy, and social behaviour in school-aged
children
SO DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY
LA English
DT Article
ID CLUMSY CHILDREN; DISORDER; CLUMSINESS; ABILITY; AUTISM; TESTS
AB Children with motor coordination problems are known to have emotional difficulties and poor social skills. The current study investigated whether children with poor motor ability have poor emotion recognition skills, and whether these could be linked to problems in social behaviour. It was hypothesized that difficulties in empathic ability might be related to the poor visuo-spatial processing ability identified in children with developmental coordination disorder (as defined by the American Psychiatric Association). The relationship between motor coordination, emotion recognition, and social behaviour was examined in a sample of 234 children (113 males, 121 females; mean age 9y 7mo, [SD 1y 8mol age range 6y 8mo to 12y 11mo). From this sample two groups of 39 children each (17 females, 22 males), one group with motor difficulties (mean age 9y 11mo [SD 2y], range 6y 11mo to 12y 11mo) and the other of control children (mean age 10y [SD 1y 11mo], range 6y 11mo to 12y 11mo), matched for age and sex, were compared using a set of six emotion recognition scales that measured both verbal and perceptual aspects of empathic ability. Children with motor difficulties were found to perform more poorly on scales measuring the ability to recognize static and changing facial expressions of emotion. This difference remained even when visuo-spatial processing was controlled. When controlling for emotion recognition and visuo-spatial organization, a child's motor ability remained a significant predictor of social behaviour.
C1 Curtin Univ Technol, Sch Psychol, Perth, WA 6845, Australia.
Griffith Univ, Sch Psychol, Nathan, Qld 4111, Australia.
RP Piek, JP (reprint author), Curtin Univ Technol, Sch Psychol, GPO Box U1987, Perth, WA 6845, Australia.
EM j.piek@curtin.edu.au
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NR 29
TC 57
Z9 58
PU CAMBRIDGE UNIV PRESS
PI NEW YORK
PA 40 WEST 20TH ST, NEW YORK, NY 10011-4211 USA
SN 0012-1622
J9 DEV MED CHILD NEUROL
JI Dev. Med. Child Neurol.
PD JUL
PY 2005
VL 47
IS 7
BP 437
EP 442
DI 10.1017/S001216220500085X
PG 6
WC Clinical Neurology; Pediatrics
SC Neurosciences & Neurology; Pediatrics
GA 941GZ
UT WOS:000230204600003
PM 15991862
ER
PT J
AU Francis, K
AF Francis, K
TI Autism interventions: a critical update
SO DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY
LA English
DT Review
ID FACILITATED COMMUNICATION; INTELLECTUAL DISABILITY; BEHAVIORAL
TREATMENT; YOUNG-CHILDREN; DISORDERS; EFFICACY; PROGRAM; ISSUES; ADULTS;
HEALTH
AB As yet, there is no aetiology-based intervention for autistic spectrum disorders (ASD); despite this, parents and professionals still need to make informed decisions regarding treatment options for children with ASD. This paper seeks to evaluate widely used interventions according to specific research criteria. Interventions presented are grouped into psychoeducational/behavioural approaches, psychopharmacological interventions, and the less traditional or complementary approaches. The conclusions are less than favourable: while some interventions do have empirical support, others have been proven to have no positive effects, and furthermore, there are no robust data favouring one approach over the others. Nevertheless, several criteria for choosing between treatment options are briefly discussed.
C1 Univ Oxford, Pk Hosp Children, Univ Sect Child & Adolescent Psychiat, Oxford OX3 7LQ, England.
RP Francis, K (reprint author), Univ Oxford, Pk Hosp Children, Univ Sect Child & Adolescent Psychiat, Old Road, Oxford OX3 7LQ, England.
EM kostas.francis@psychiatry.oxford.ac.uk
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NR 46
TC 39
Z9 39
PU CAMBRIDGE UNIV PRESS
PI NEW YORK
PA 40 WEST 20TH ST, NEW YORK, NY 10011-4211 USA
SN 0012-1622
J9 DEV MED CHILD NEUROL
JI Dev. Med. Child Neurol.
PD JUL
PY 2005
VL 47
IS 7
BP 493
EP 499
DI 10.1017/S0012162205000952
PG 7
WC Clinical Neurology; Pediatrics
SC Neurosciences & Neurology; Pediatrics
GA 941GZ
UT WOS:000230204600013
PM 15991872
ER
PT J
AU Pring, L
AF Pring, L
TI Savant talent
SO DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY
LA English
DT Review
ID AUTISM; ABILITY; SUBJECT; SKILLS
AB The notion of talent is an elusive concept but there appears to be sound evidence that both savants and experts share important qualities. Brief descriptive accounts of the talents displayed by savants are presented, along with a discussion of intelligence, implicit learning, and the organization of knowledge. Cognitive theories helpful in understanding exceptional abilities in people with autism are also discussed. It is concluded that a certain cognitive style, i.e. weak coherence, may predispose individuals to develop their talents. Although it would be interesting to speculate that some great artists and mathematicians show a similar degree of obsessive preoccupation and a cognitive style reminiscent of autistic spectrum disorder, presumably as a strategic mechanism, there is, as yet, little research on the subject.
C1 Univ London Goldsmiths Coll, Dept Psychol, London SE14 6NW, England.
RP Pring, L (reprint author), Univ London Goldsmiths Coll, Dept Psychol, London SE14 6NW, England.
EM l.pring@gold.ac.uk
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NR 36
TC 23
Z9 23
PU CAMBRIDGE UNIV PRESS
PI NEW YORK
PA 40 WEST 20TH ST, NEW YORK, NY 10011-4211 USA
SN 0012-1622
J9 DEV MED CHILD NEUROL
JI Dev. Med. Child Neurol.
PD JUL
PY 2005
VL 47
IS 7
BP 500
EP 503
DI 10.1017/S0012162205000976
PG 4
WC Clinical Neurology; Pediatrics
SC Neurosciences & Neurology; Pediatrics
GA 941GZ
UT WOS:000230204600014
PM 15991873
ER
PT J
AU Jarrold, C
Gilchrist, ID
Bender, A
AF Jarrold, C
Gilchrist, ID
Bender, A
TI Embedded figures detection in autism and typical development:
preliminary evidence of a double dissociation in relationships with
visual search
SO DEVELOPMENTAL SCIENCE
LA English
DT Article
ID WEAK CENTRAL COHERENCE; ENHANCED DISCRIMINATION; INDIVIDUALS;
PERFORMANCE; ILLUSIONS; CHILDREN; TESTS; TASKS
AB Individuals with autism show relatively strong performance on tasks that require them to identify the constituent parts of a visual stimulus. This is assumed to be the result of a bias towards processing the local elements in a display that follows from a weakened ability to integrate information at the global level. The results of the current study showed that, among children with autism, ability to locate a figure embedded in a larger stimulus was only related to performance on visual search trials where the target was identified by a unique perceptual feature. In contrast, control children's embedded figures performance was specifically related to their performance on visual search trials where the target was defined by a conjunction of features. This double dissociation suggests that enhanced performance on perceptual tasks by children with autism is not simply a consequence of a quantitative difference in ability to engage in global processing.
C1 Univ Bristol, Dept Expt Psychol, Bristol BS8 1TN, Avon, England.
RP Jarrold, C (reprint author), Univ Bristol, Dept Expt Psychol, 8 Woodland Rd, Bristol BS8 1TN, Avon, England.
EM C.Jarrold@bristol.ac.uk; I.D.Gilchrist@bristol.ac.uk
RI Gilchrist, Iain/E-8627-2010
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NR 29
TC 54
Z9 55
PU BLACKWELL PUBLISHING
PI OXFORD
PA 9600 GARSINGTON RD, OXFORD OX4 2DG, OXON, ENGLAND
SN 1363-755X
J9 DEVELOPMENTAL SCI
JI Dev. Sci.
PD JUL
PY 2005
VL 8
IS 4
BP 344
EP 351
DI 10.1111/j.1467-7687.2005.00422.x
PG 8
WC Psychology, Developmental; Psychology, Experimental
SC Psychology
GA 945JT
UT WOS:000230499500007
PM 15985068
ER
PT J
AU Dumortier, G
Welniarz, B
Sauvebois, C
Medjdoub, H
Friche, H
Said, N
Degrassat, K
AF Dumortier, G
Welniarz, B
Sauvebois, C
Medjdoub, H
Friche, H
Said, N
Degrassat, K
TI Prescription of psychotropic drugs in paediatry : approved indications
and therapeutic perspectives
SO ENCEPHALE-REVUE DE PSYCHIATRIE CLINIQUE BIOLOGIQUE ET THERAPEUTIQUE
LA French
DT Article
DE adolescent; child; information; pharmacovigilence; psychotropic drug;
unlabelled uses
ID OBSESSIVE-COMPULSIVE DISORDER; PERVASIVE DEVELOPMENTAL DISORDERS;
CHILDHOOD-ONSET SCHIZOPHRENIA; SEROTONIN REUPTAKE INHIBITORS;
PLACEBO-CONTROLLED TRIAL; DOUBLE-BLIND; AUTISTIC DISORDER;
AGGRESSIVE-CHILDREN; ANXIETY DISORDERS; CONDUCT DISORDER
AB In France, psychotropic drugs may be classified in four categories according to their official data. The first category corresponds to psychotropic drugs with an approved indication available in paediatry. They are old agents (eg haloperidol, amitriptyline, benzodiazepines...) with the exception of methylphenidate (hyperactivity). The second one corresponds to pharmacological agents approved for some indications obtained with adults but not for all (ie restricted indication:e.g. sertraline approved in paediatry only for OCD but not for depression, risperidone approved only for the treatment of disruptive behaviors in children with subaverage IQs). For the third category, the psychotropic agent is either contraindicated or unadvised under the age of 15 or 18 years, by lack of data (eg most of SSRI or atypical antipsychotic drugs). For the last category, official data available in brief summaries offer no information on paediatric use and consequently their ad ministration does not appear possible. Up to now, no approved use has been delivered to injection route (IM or IV) in France, except for an IM formulation of zuclopenthixol. Prescribing psychotropic drug has to respect good practices including close psychological and somatic monitoring that associates the young patient and his relative (psycho-education program). Particular key-points should be taken into consideration (ie pharmacokinetic and physiological specificities, risk of false passage under the age of 6 years with capsules or tablets, presence of alcohol in some oral solution or bitter aroma...). Beside these official data, many studies have been published but must be carefully interpreted according to their level of pertinence. Meta-analysis gather all randomised controlled trials published or not, analyse their specific pertinence and thus provide clinically relevant elements. Randomised controlled trials present clinical interest but key-points in study design must be checked (eg number of patients, inclusion and exclusion criteria, length of the study and clinical relevance of clinical scales...). Other studies like open trials or clinical cases do not offer sufficient guarantees. Some randomised controlled trials of clinical relevance have been carried out in this population with new pharmacological classes (eg SSRI, atypical antipsychotic drugs) and may lead to extended indications in children and adolescents. According to bibliographic and official data, the main criteria in the prescribing choice may take into consideration the following key-points : in case of infantile depression, tricyclic antidepressive drugs should not be used according to meta-analysis stressing a poor benefit/risk ratio. SSRI may offer better prospects but their use has not been approved in this indication, until now. In OCD, sertraline shows great interest to enhance clinical response and represents the molecule of reference. No drug has been approved for mood disorders in children or adolescent, in France, contrary to USA where lithium can be administered over the age of 12 years. In addition, antiepileptic drugs like carbamazepine or divalproate have conducted to clinical improvement in some studies. Benzodiazepines, hydroxyzine and meprobamate use should be strictly restricted in case of anxiety symptoms but are the only agents approved in this indication despise promising results obtained with SSRI. Transitory insomnia may take advantage of alimemazine prescription (approved use over the age of 36 months).
Some typical neuroleptics are indicated in tics or in behaviour disorders associaed to autism or related syndromes but present clinical limitations and poor tolerability. Promising clinical trials (randomised or not) have been conducted with new atypical antipsychotic drugs like risperidone. In conclusion, present data available for paediatric use of psychotropic agents emphasizes that safety and effectiveness are not always well established in particular for the treatment of chronic disorders (long term tolerability assessment). Moreover, studies should be carried out to specify factors promoting adherence and quality of life for this young population in order to optimise clinical benefit of drug prescription.
C1 EPS Ville Evrard, Serv Pharm, F-93332 Neuilly Sur Marne, France.
EPS Ville Evrard, Secteur 93103, F-93332 Neuilly Sur Marne, France.
RP Dumortier, G (reprint author), EPS Ville Evrard, Serv Pharm, 202 Ave Jean Jaures, F-93332 Neuilly Sur Marne, France.
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NR 83
TC 4
Z9 4
PU MASSON EDITEUR
PI MOULINEAUX CEDEX 9
PA 21 STREET CAMILLE DESMOULINS, ISSY, 92789 MOULINEAUX CEDEX 9, FRANCE
SN 0013-7006
J9 ENCEPHALE
JI Enceph.-Rev. Psychiatr. Clin. Biol. Ther.
PD JUL-AUG
PY 2005
VL 31
IS 4
BP 477
EP 489
PN 1
PG 13
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA 988JK
UT WOS:000233590300009
PM 16389715
ER
PT J
AU de Vries, P
Humphrey, A
McCartney, D
Prather, P
Bolton, P
Hunt, A
AF de Vries, P
Humphrey, A
McCartney, D
Prather, P
Bolton, P
Hunt, A
CA TSC Behaviour Consensus Panel
TI Consensus clinical guidelines for the assessment of cognitive and
behavioural problems in Tuberous Sclerosis
SO EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
LA English
DT Article
DE Tuberous Sclerosis; clinical guidelines; cognition behaviour
ID LEARNING-DISABILITY; ATTENTION DEFICITS; CHILDREN; COMPLEX; DISORDERS;
EPILEPSY; AUTISM; HEALTH
AB Tuberous Sclerosis (TSC) is a genetic disorder characterised by abnormal growths in a wide range of organs. In the brain, abnormalities of differentiation, proliferation and migration can produce a range of neuropsychiatric features such as mental retardation, autism and ADHD. Although these manifestations are not diagnostic of the disorder, cognitive and behavioural features are often of greatest concern to families yet limited clinical assessment and interventions are currently offered. A consensus panel at a TSC Brain/Behaviour workshop recommended that the cognitive and behavioural profiles of individuals with TSC should be assessed at regular intervals in a planned fashion in accordance with the difficulties associated with the disorder. Evaluations should include the use of standardised neuropsychological and behavioural tools as appropriate to the age and developmental level of the individual assessed. These cognitive and behavioural profiles should be incorporated in the overall formulation of the needs of the person with TSC to plan educational, social and clinical management strategies. Assessments should be documented so that individual longitudinal progress can be monitored. The paper outlines the problems associated with TSC, the purpose of recommended assessments, developmentally appropriate stages for assessment, and identifies specific areas that should be targeted for assessment.
C1 TB Sclerosis Assoc, N Leigh OX29 6TX, Witney, England.
Inst Psychiat, Child & Adolescent Psychiat Dept, London, England.
Inst Psychiat, MRC, Ctr Social Genet & Dev Psychiat, London, England.
Harvard Univ, Sch Med, Boston, MA 02115 USA.
Massachusetts Gen Hosp, Dept Neurol, Boston, MA 02115 USA.
Massachusetts Gen Hosp, Dept Psychiat, Boston, MA 02115 USA.
Univ Cambridge, Dev Psychiat Sect, Cambridge, England.
RP Hunt, A (reprint author), TB Sclerosis Assoc, Church Farm House,Church Rd, N Leigh OX29 6TX, Witney, England.
EM research@tuberous-sclerosis.org
RI Bolton, Patrick/E-8501-2010
OI Bolton, Patrick/0000-0002-5270-6262
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World Health Organziation, 1992, ICD10 CLASS MENT BEH
NR 41
TC 35
Z9 36
PU DR DIETRICH STEINKOPFF VERLAG
PI DARMSTADT
PA PO BOX 10 04 62, D-64204 DARMSTADT, GERMANY
SN 1018-8827
J9 EUR CHILD ADOLES PSY
JI Eur. Child Adolesc. Psych.
PD JUL
PY 2005
VL 14
IS 4
BP 183
EP 190
DI 10.1007/s00787-005-0443-1
PG 8
WC Psychology, Developmental; Pediatrics; Psychiatry
SC Psychology; Pediatrics; Psychiatry
GA 943ZU
UT WOS:000230395500001
PM 15981129
ER
PT J
AU Chauhan, A
Chauhan, V
Cohen, I
AF Chauhan, A
Chauhan, V
Cohen, I
TI Increased serum complement C3 and C4 levels in autism: a correlation
with severity and language disability
SO FEBS JOURNAL
LA English
DT Meeting Abstract
CT IUBMB 50th Anniversary Symposium
CY JUL 02-07, 2005
CL Budapest, HUNGARY
SP Int Union Biochem Molecular Biol
C1 NYS Inst Basic Res, Dept Psychol, Lab Behav Assess & Res, Staten Isl, NY USA.
NYS Inst Basic Res, Dept Neurochem, Lab Cellular Neurochem, Staten Isl, NY USA.
EM abhachauhan@aol.com
CR Chauhan A, 2004, LIFE SCI, V75, P2539, DOI 10.1016/j.lfs.2004.04.038
NR 1
TC 2
Z9 2
PU BLACKWELL PUBLISHING
PI OXFORD
PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND
SN 1742-464X
J9 FEBS J
JI FEBS J.
PD JUL
PY 2005
VL 272
SU 1
BP 492
EP 493
PG 2
WC Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA 005MG
UT WOS:000234826102499
ER
PT J
AU Wassink, TH
Losh, M
Frantz, RS
Vieland, VJ
Goedken, R
Piven, J
Sheffield, VC
AF Wassink, TH
Losh, M
Frantz, RS
Vieland, VJ
Goedken, R
Piven, J
Sheffield, VC
TI A case of autism and uniparental disomy of chromosome 1
SO HUMAN GENETICS
LA English
DT Article
ID PRADER-WILLI-SYNDROME; MAJOR SUSCEPTIBILITY LOCUS; ANGELMAN-SYNDROME;
SPECTRUM DISORDERS; FAMILY HISTORY; SCHIZOPHRENIA; INDIVIDUALS;
ISODISOMY; MUTATIONS; LINKAGE
AB We report a male child with autism found to have maternal uniparental disomy ( UPD) of chromosome 1. The child met diagnostic criteria for the three symptom domains of autism: language impairment, deficient social communication and excessively rigid and repetitive behaviours. He also had a variety of features often associated with autism, including mild mental retardation, small head circumference, hyperactivity, poor. ne motor skills, slightly dysmorphic facial features and a heightened interest in olfactory stimulation. His brother, who did not have chromosome 1 UPD, was also autistic. The mother, but not the father, had a history of psychiatric illness and a number of personality and social traits similar to the core features of autism. The discovery of the cytogenetic abnormality was made during the course of a genome- wide linkage screen, wherein genotypes at 6 out of 17 chromosome 1 markers were non- Mendelian and all transmissions were consistent with UPD. Further genotyping ( a total of 54 markers) revealed alternating regions of heterodisomy and isodisomy. Whereas chromosome 1 UPD has not been shown to cause disease by effects on imprinting, numerous reports exist of the abnormality unmasking recessive disease- causing mutations. In agreement with this, one of the regions of isodisomy overlaps an emerging chromosome 1 region of interest in autism located at 150 - 160 Mb.
C1 Univ Iowa, Carver Coll Med, Dept Psychiat, Iowa City, IA 52242 USA.
Univ N Carolina, Neurodev Disorders Res Ctr, Chapel Hill, NC USA.
Univ N Carolina, Dept Psychiat, Chapel Hill, NC USA.
Univ Iowa, Coll Publ Hlth, Ctr Stat Genet Res, Iowa City, IA 52242 USA.
Univ Iowa, Coll Publ Hlth, Program Publ Hlth Genet, Iowa City, IA 52242 USA.
Univ Iowa, Dept Pediat, Iowa City, IA 52242 USA.
Univ Iowa, Carver Coll Med, Howard Hughes Med Inst, Iowa City, IA 52242 USA.
RP Wassink, TH (reprint author), Univ Iowa, Carver Coll Med, Dept Psychiat, Iowa City, IA 52242 USA.
EM thomas-wassink@uiowa.edu
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NR 36
TC 9
Z9 9
PU SPRINGER
PI NEW YORK
PA 233 SPRING STREET, NEW YORK, NY 10013 USA
SN 0340-6717
J9 HUM GENET
JI Hum. Genet.
PD JUL
PY 2005
VL 117
IS 2-3
BP 200
EP 206
DI 10.1007/s00439-005-1257-4
PG 7
WC Genetics & Heredity
SC Genetics & Heredity
GA 937OP
UT WOS:000229935700011
PM 15887000
ER
PT J
AU Biringen, Z
Fidler, DJ
Barrett, KC
Kubicek, L
AF Biringen, Z
Fidler, DJ
Barrett, KC
Kubicek, L
TI Applying the emotional availability scales to children with disabilities
SO INFANT MENTAL HEALTH JOURNAL
LA English
DT Review
ID PRADER-WILLI-SYNDROME; DOWN-SYNDROME; MENTAL-RETARDATION;
AUTISTIC-CHILDREN; JOINT ATTENTION; DEVELOPMENTAL-DISABILITIES;
BEHAVIORAL PHENOTYPES; HANDICAPPED CHILDREN; COGNITIVE-ABILITIES;
PRESCHOOL-CHILDREN
AB In this article, we describe issues regarding emotional availability and its application to children with disabilities. We then apply this approach to the scoring of emotional availability for caregiver-child interactions of children with disabilities, with information based on children with genetic mental retardation syndromes, children with autism, and children with hearing impairments.
C1 Colorado State Univ, Dept Human Dev & Family Studies, Ft Collins, CO 80523 USA.
Univ Colorado, Hlth Sci Ctr, Boulder, CO 80309 USA.
RP Biringen, Z (reprint author), Colorado State Univ, Dept Human Dev & Family Studies, Ft Collins, CO 80523 USA.
EM biringen@cahs.colostate.edu
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NR 106
TC 17
Z9 17
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0163-9641
J9 INFANT MENT HEALTH J
JI Infant Ment. Health J.
PD JUL-AUG
PY 2005
VL 26
IS 4
BP 369
EP 391
DI 10.1002/imhj.20058
PG 23
WC Psychology, Developmental
SC Psychology
GA 948FP
UT WOS:000230701700006
ER
PT J
AU Chakrabarti, S
Haubus, C
Dugmore, S
Orgill, G
Devine, F
AF Chakrabarti, S
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TI A model of early detection and diagnosis of autism spectrum disorder in
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SO INFANTS AND YOUNG CHILDREN
LA English
DT Article
DE asperger syndrome; autism; autism spectrum disorder; diagnosis; early
detection; early intervention; pervasive developmental disorder not
otherwise specified; preschool children; screening
ID PERVASIVE DEVELOPMENTAL DISORDERS; INDIVIDUALS; PREVALENCE; INSTRUMENT;
INTERVIEW; CHECKLIST; TODDLERS; BEHAVIOR
AB Autism and autism spectrum disorder (ASD) are a group of severe developmental disorders that are characterized by 3 core sets of developmental abnormalities: impairment of social interaction, verbal and nonverbal communication, and restricted, repetitive patterns of behavior. The disorder is far more common than previously thought. There is no cure for autism but it is apparent that early detection followed by early intervention is likely to provide the best chance of long-term beneficial outcome in this condition. Unfortunately, until recently, there had been no validated method of comprehensive early detection of ASD, nor a tool with adequate sensitivity and specificity to be recommended for universal screening of preschool children with ASD. We describe a model of comprehensive early detection and diagnosis of ASD that is achieved by using the resources of primary care workers and a multidisciplinary team with skill and experience in assessing developmental problems in young children and specific expertise in ASD. Both early detection and diagnosis may be carried out by this team in collaboration with parents and primary care professionals and can result in high rates of detection and diagnosis of ASD.
C1 Cent Clin, Child Dev Ctr, Stafford ST16 3AE, England.
RP Chakrabarti, S (reprint author), Cent Clin, Child Dev Ctr, Stafford ST16 3AE, England.
EM sunit@doctors.org.uk
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World Health Organziation, 1992, ICD10 CLASS MENT BEH
NR 43
TC 6
Z9 7
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0896-3746
J9 INFANT YOUNG CHILD
JI Infants Young Child.
PD JUL-SEP
PY 2005
VL 18
IS 3
BP 200
EP 211
PG 12
WC Education, Special; Psychology, Developmental; Rehabilitation
SC Education & Educational Research; Psychology; Rehabilitation
GA 937IV
UT WOS:000229918700004
ER
PT J
AU Romanczyk, RG
Gillis, JM
Noyes-Grosser, DM
Holland, PP
Holland, CL
Lyons, D
AF Romanczyk, RG
Gillis, JM
Noyes-Grosser, DM
Holland, PP
Holland, CL
Lyons, D
TI Clinical clues, developmental milestones, and early
identification/assessment of children with disabilities: Practical
applications and conceptual considerations
SO INFANTS AND YOUNG CHILDREN
LA English
DT Article
DE autism; clinical clues; clinical practice guidelines; communication
disorders; developmental disabilities; developmental surveillance; Down
syndrome; early intervention; hearing loss; motor disorders; vision
impairment; young children
ID AUTISM
AB The New York State Department of Health initiated the development of 6 clinical practice guidelines for children under 3 years of age with those developmental conditions most often seen in the state's Early Intervention Program. Separate guidelines were developed for autism/pervasive developmental disorders, communication disorders, Down syndrome, hearing impairment, motor disorders, and vision impairment. Professionals providing early intervention set-vices are confronted with complex issues regarding service provision. This article focuses upon identification and assessment methods recommended by these 6 guidelines. The guidelines specifically emphasize the importance of routine developmental surveillance where primary healthcare providers use both clinical clues and developmental milestones, as signals for further focused screening and in-depth assessment to detect possible developmental conditions. Given the wide variation in timing for reaching specific milestones seen among typically developing children, the use of developmental milestone tables alone may miss opportunities for early identification, which may result in unnecessary "wait and see" recommendations to parents. The use of disorder-specific clinical clues may offer a more efficient and accurate method of developmental surveillance that facilitates earlier identification of infants and young children with developmental disabilities who may benefit from early intervention services.
C1 SUNY Binghamton, Inst Child Dev, Binghamton, NY USA.
New York State Dept Hlth, Policy & Clin Serv, Early Intervent Program, New York, NY USA.
Holland Associates, Seattle, WA USA.
RP Romanczyk, RG (reprint author), SUNY Binghamton, Inst Child Dev, Binghamton, NY USA.
CR *AM AC PED, 2002, DEV MIL
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NR 16
TC 3
Z9 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0896-3746
J9 INFANT YOUNG CHILD
JI Infants Young Child.
PD JUL-SEP
PY 2005
VL 18
IS 3
BP 212
EP 221
PG 10
WC Education, Special; Psychology, Developmental; Rehabilitation
SC Education & Educational Research; Psychology; Rehabilitation
GA 937IV
UT WOS:000229918700005
ER
PT J
AU Rugino, TA
Janvier, YM
AF Rugino, TA
Janvier, YM
TI Aripiprazole in children and adolescents: Clinical experience
SO JOURNAL OF CHILD NEUROLOGY
LA English
DT Article
ID ATYPICAL ANTIPSYCHOTIC-DRUG; RISPERIDONE TREATMENT; AGGRESSIVE-BEHAVIOR;
YOUNG-CHILDREN; AUTISM; CLASSIFICATION; SCHIZOPHRENIA; PHARMACOLOGY;
DISORDERS; DOPAMINE
AB Despite few supportive data, aripiprazole was being administered to children and adolescents for management of mood instability, aggression, and psychosis. Using a retrospective review (n = 11) and prospective recruitment (n = 6), 17 children and adolescents received aripiprazole 5 to 20 mg/day. Only 4 of 16 bipolar and autistic subjects (25%) demonstrated reduced aggression without adverse events, and the symptoms of 2 of 4 psychotic subjects improved. Coadministration of sedative medications (particularly guanfacine or clonidine) and weight < 58 kg increased the risk of adverse events, such as increased lability and aggression. All three children < 8.6 years old, all four children < 34 kg, and all five children receiving alpha(2)-agonists developed adverse events prior to clinical efficacy. Age > 11 years, weight > 58 kg, and absence of sedative medications were associated with a 56% (five of nine) success rate. Until larger, prospective studies are completed, caution is advised when considering aripiprazole for smaller children and children receiving sedative medications.
C1 Childrens Specialized Hosp, Toms River, NJ 08755 USA.
RP Rugino, TA (reprint author), Childrens Specialized Hosp, 94 Stevens Rd, Toms River, NJ 08755 USA.
EM trugino@childrens-specialized.org
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NR 39
TC 31
Z9 31
PU B C DECKER INC
PI HAMILTON
PA 20 HUGHSON ST SOUTH, PO BOX 620, L C D 1, HAMILTON, ONTARIO L8N 3K7,
CANADA
SN 0883-0738
J9 J CHILD NEUROL
JI J. Child Neurol.
PD JUL
PY 2005
VL 20
IS 7
BP 603
EP 610
PG 8
WC Clinical Neurology; Pediatrics
SC Neurosciences & Neurology; Pediatrics
GA 953AT
UT WOS:000231048600013
PM 16159529
ER
PT J
AU Boyle, C
Alexander, M
AF Boyle, C
Alexander, M
TI Public health research at the CDC: Implications for communication
sciences and disorders
SO JOURNAL OF COMMUNICATION DISORDERS
LA English
DT Article; Proceedings Paper
CT 14th Annual Research Symposium
CY 2004
CL Philadelphia, PA
SP Amer Speech & Hearing Assoc, Natl Inst Deafness & Other Commmun Disorders
ID PREVALENCE; AUTISM; RISK
AB The following paper provides an overview of public health research at the Centers for Disease Control and Prevention (CDC), with emphasis on research involving speech, language and hearing disorders. Public health research involves a sequence of activities from disease tracking to disease prevention. Public health focuses on populations and works to identify changes in programs and policies that can positively impact population health. This paper uses three recent studies conducted by CDC investigators to illustrate different types of research along the public health prevention continuum, with emphasis on activities involving speech, language, and hearing endpoints. The three examples are: a study of cochlear implants and the subsequent risk of meningitis (illustrative of a public health response); a study examining the prevalence of autism in several U.S. populations (an example of a surveillance or monitoring activity); and a study examining the role of in utero cigarette exposure in the etiology of oral facial clefts (illustrative of a epidemiologic risk factor study). The public health continuum provides an important vehicle for advancing our knowledge of the causes and effective prevention of communication disorders.
Learning outcomes: The reader will become familiar with the public health sequence and the manners in which public health research relates to speech, language, and hearing disorders. The reader will be able to identify and discriminate among the components of public health research using the examples provided. Published by Elsevier Inc.
C1 CDCP, Div Birth Defects & Dev Disabil, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USA.
RP Boyle, C (reprint author), CDCP, Div Birth Defects & Dev Disabil, Natl Ctr Birth Defects & Dev Disabil, 1600 Clifton Rd,Mailstop E86, Atlanta, GA 30333 USA.
EM cboyle@cdc.gov
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THACKER SB, 2000, PRINCIPLES PRACTICES
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Yoon PW, 2001, PUBLIC HEALTH REP, V116, P32, DOI 10.1093/phr/116.S1.32
NR 8
TC 0
Z9 2
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0021-9924
J9 J COMMUN DISORD
JI J. Commun. Disord.
PD JUL-AUG
PY 2005
VL 38
IS 4
BP 263
EP 270
DI 10.1016/j.jcomdis.2005.02.002
PG 8
WC Audiology & Speech-Language Pathology; Linguistics; Rehabilitation
SC Audiology & Speech-Language Pathology; Linguistics; Rehabilitation
GA 929LI
UT WOS:000229347200002
PM 15862809
ER
PT J
AU Eikeseth, S
AF Eikeseth, S
TI Intensive behavioural intervention for children with autism. A reply to
Prior
SO JOURNAL OF PAEDIATRICS AND CHILD HEALTH
LA English
DT Letter
ID PERVASIVE DEVELOPMENTAL DISORDER; YOUNG-CHILDREN
C1 Akershus Univ Coll, Lillestrom, Norway.
RP Eikeseth, S (reprint author), Akershus Univ Coll, Lillestrom, Norway.
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NR 16
TC 0
Z9 0
PU BLACKWELL PUBLISHING
PI OXFORD
PA 9600 GARSINGTON RD, OXFORD OX4 2DG, OXON, ENGLAND
SN 1034-4810
J9 J PAEDIATR CHILD H
JI J. Paediatr. Child Health
PD JUL
PY 2005
VL 41
IS 7
BP 391
EP 392
DI 10.1111/j.1440-1754.2005.00644_2.x
PG 2
WC Pediatrics
SC Pediatrics
GA 942SM
UT WOS:000230302700021
PM 16014152
ER
PT J
AU Kelemen, O
Erdelyi, R
Pataki, I
Benedek, G
Janka, Z
Keri, S
AF Kelemen, O
Erdelyi, R
Pataki, I
Benedek, G
Janka, Z
Keri, S
TI Theory of mind and motion perception in schizophrenia
SO NEUROPSYCHOLOGY
LA English
DT Article
DE schizophrenia; theory of mind; motion perception; cognition
ID ASPERGER-SYNDROME; SOCIAL COGNITION; FACIAL RECOGNITION; VISUAL-SYSTEM;
HUMAN BRAIN; AUTISM; PEOPLE; DISORDER; CHILDREN; DEFICIT
AB This study investigated the relationship between theory of mind (ToM) deficits and visual perception in patients with schizophrenia (N = 52; 17 remitted and unmedicated) compared with healthy controls (N = 30). ToM was assessed with the Eyes Test, which asked participants to choose which of 4 words best described the mental state of a person whose eyes were depicted in a photograph. Visual perception was evaluated with form and motion coherence threshold measurements. Results revealed that patients with schizophrenia (both remitted and nonremitted) showed deficits on the Eyes Test and the motion coherence task. ToM dysfunctions were associated with higher motion coherence thresholds and more severe negative symptoms. This suggests that ToM deficits are related to motion perception dysfunctions, which indicates a possible role of motion-sensitive areas in the pathophysiology of schizophrenia.
C1 Univ Szeged, Dept Psychiat, H-6725 Szeged, Hungary.
Bacs Kiskun Cty Hosp, Psychiat Ctr, Kecksemet, Hungary.
Univ Szeged, Dept Psychiat, Szeged, Hungary.
Univ Szeged, Dept Physiol, Szeged, Hungary.
RP Keri, S (reprint author), Univ Szeged, Dept Psychiat, Semmelweis 6, H-6725 Szeged, Hungary.
EM szkeri@phys.szote.u-szeged.hu
RI Keri, Szabolcs/E-5239-2011
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TC 42
Z9 42
PU AMER PSYCHOLOGICAL ASSOC/EDUCATIONAL PUBLISHING FOUNDATION
PI WASHINGTON
PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA
SN 0894-4105
J9 NEUROPSYCHOLOGY
JI Neuropsychology
PD JUL
PY 2005
VL 19
IS 4
BP 494
EP 500
DI 10.1037/0894-4105.19.4.494
PG 7
WC Psychology, Clinical; Neurosciences; Psychology
SC Psychology; Neurosciences & Neurology
GA 951BC
UT WOS:000230902800010
PM 16060824
ER
PT J
AU Coplan, J
Jawad, AF
AF Coplan, J
Jawad, AF
TI Modeling clinical outcome of children with autistic spectrum disorders
SO PEDIATRICS
LA English
DT Article; Proceedings Paper
CT 2nd National-Center-on-Birth-Defects-and-Developmental-Disabilities
Conference
CY JUL 25-26, 2004
CL Washington, DC
SP Natl Ctr Birth Defects & Dev Disabil
DE autism; autistic spectrum disorders; pervasive developmental disorder;
developmental disabilities
ID FOLLOW-UP; INTELLIGENCE; ADULTS; AGE; IQ
AB Objectives. Autistic spectrum disorders (ASD) have variable developmental outcomes, for reasons that are not entirely clear. The objective of this study was to test the clinical observation that initial developmental parameters (degree of atypicality and level of intelligence) are a major predictor of outcome in children with ASD and to develop a statistical method for modeling outcome on the basis of these parameters.
Methods. A retrospective chart review was conducted of a child development program at a tertiary center for the evaluation of children with developmental disabilities. All children who had ASD, were seen by J. C. between July 1997 and December 2002, met Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) criteria for autism or pervasive developmental disorder (referred to hereafter as ASD), had undergone at least 1 administration of the Childhood Autism Rating Scale (CARS), and had at least 1 determination of developmental quotient (DQ) or IQ (N = 91) were studied. The sample was 92.3% male and 80.2% white.
Methods. The DSM-IV was used to confirm that each patient met criteria for a diagnosis of autism or pervasive developmental disorder. The CARS was used to quantify the severity of expression of ASD. Age at evaluation, CARS score, and DQ or IQ at each visit were extracted from the medical record. The 2 independent sample t test or the Mann-Whitney test was used for comparing CARS and age between 2 groups: first recorded DQ or IQ < 0.70 (n = 58) versus first recorded DQ or IQ >= 0.70 (n = 33). Associations among CARS score, IQ or DQ, and age were examined using Pearson or Spearman correlation. A mixed-effect model was used for expressing the multivariate model. Length of follow-up ( period) was calculated by subtracting age in months at initial evaluation from age in months at each follow-up evaluation. Therefore, at first evaluation, period = 0. Period was considered as a random effect because collection of repeated information from patients was not uniform. The predictive relationships among CARS, age at first evaluation, period, and DQ or IQ group (< 0.70 and >= 0.70) were examined using a mixed-effects model. Variables that were expressed as percentage change between first and last measurements were analyzed using the t test or the Mann-Whitney test. Socioeconomic status was assessed using Hollingshead criteria.
Results. All patients met DSM-IV criteria for ASD. Mean age at initial evaluation was 46.2 months (SD: 23.7; range: 20.0-167.3 months). Mean CARS score at initial evaluation was 36.1 (SD: 6.3; range: 21.5-48). Mean DQ or IQ at initial evaluation was 0.65 (SD: 0.20; range: 0.16-1.10). There was no significant difference in socioeconomic status between DQ/IQ groups. CARS scores among children with an initial DQ or IQ < 0.70 showed no significant decrement with time. In contrast, CARS scores among children with an initial DQ or IQ >= 0.70 showed a significant decrement with time, which could be modeled by the formula CARS = 37.93 - [(0.12 x age in months at first visit) + (0.23 x period)]. The predicted CARS scores generated by this model correlated with the observed values (r = 0.71) and explained 50% of the variability in the CARS scores for this group.
Conclusions. These data provide preliminary validation of a statistical model for clinical outcome of ASD on the basis of 3 parameters: age, degree of atypicality, and level of intelligence. This model, if replicated in a prospective, population-based sample that is controlled for treatment modalities, will enhance our ability to offer a prognosis for the child with ASD and will provide a benchmark against which to judge the putative benefits of various treatments for ASD. Our model may also be useful in etiologic and epidemiologic studies of ASD, because different causes of ASD are likely to follow different developmental trajectories along these 3 parameters.
C1 Univ Penn, Sch Med, Philadelphia, PA 19104 USA.
Childrens Hosp Philadelphia, Philadelphia, PA 19104 USA.
RP Coplan, J (reprint author), Neurodev Pediat Main Line PC, Rosemont Business Campus,Bldg 1,Suite 100,919 Con, Rosemont, PA 19010 USA.
EM coplan@ndpeds.com
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NR 31
TC 14
Z9 18
PU AMER ACAD PEDIATRICS
PI ELK GROVE VILLAGE
PA 141 NORTH-WEST POINT BLVD,, ELK GROVE VILLAGE, IL 60007-1098 USA
SN 0031-4005
J9 PEDIATRICS
JI Pediatrics
PD JUL
PY 2005
VL 116
IS 1
BP 117
EP 122
DI 10.1542/peds.2004-1118
PG 6
WC Pediatrics
SC Pediatrics
GA 941IC
UT WOS:000230207500041
PM 15995041
ER
PT J
AU Rubin, R
AF Rubin, R
TI Response to "Scientifically unsupported and supported interventions for
childhood psychopathology: A summary"
SO PEDIATRICS
LA English
DT Letter
ID FACILITATED COMMUNICATION; AUTISM
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NR 17
TC 3
Z9 3
PU AMER ACAD PEDIATRICS
PI ELK GROVE VILLAGE
PA 141 NORTH-WEST POINT BLVD,, ELK GROVE VILLAGE, IL 60007-1098 USA
SN 0031-4005
J9 PEDIATRICS
JI Pediatrics
PD JUL
PY 2005
VL 116
IS 1
BP 289
EP 289
DI 10.1542/peds.2005-0713
PG 1
WC Pediatrics
SC Pediatrics
GA 941IC
UT WOS:000230207500075
PM 15995075
ER
PT J
AU Kliewer, C
Broderick, A
Oyler, C
Cardinal, DN
Kluth, P
Moeschler, JB
Schneiderman, H
AF Kliewer, C
Broderick, A
Oyler, C
Cardinal, DN
Kluth, P
Moeschler, JB
Schneiderman, H
TI Response to "Scientifically unsupported and supported interventions for
childhood psychopathology: A summary"
SO PEDIATRICS
LA English
DT Letter
ID FACILITATED COMMUNICATION; AUTISM; AUTHORSHIP; DIAGNOSIS
C1 Univ No Iowa, Dept Special Educ, Cedar Falls, IA 50614 USA.
Columbia Univ, Curriculum & Teaching Teachers Coll, New York, NY 10027 USA.
Chapman Univ, Sch Educ, Orange, CA 92866 USA.
Autism Consultat, Chicago, IL 60630 USA.
Dartmouth Hitchcock Med Ctr, Dept Pediat, Dartmouth Med Sch, Div Genet & Child Dev, Lebanon, NH 03765 USA.
Upstate Med Univ, Dept Pediat, Syracuse, NY 13210 USA.
RP Kliewer, C (reprint author), Univ No Iowa, Dept Special Educ, Cedar Falls, IA 50614 USA.
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TC 1
Z9 1
PU AMER ACAD PEDIATRICS
PI ELK GROVE VILLAGE
PA 141 NORTH-WEST POINT BLVD,, ELK GROVE VILLAGE, IL 60007-1098 USA
SN 0031-4005
J9 PEDIATRICS
JI Pediatrics
PD JUL
PY 2005
VL 116
IS 1
BP 290
EP 290
DI 10.1542/peds.2005-0742
PG 1
WC Pediatrics
SC Pediatrics
GA 941IC
UT WOS:000230207500076
PM 15995077
ER
PT J
AU Lilienfeld, SO
AF Lilienfeld, SO
TI Response to "Scientifically unsupported and supported interventions for
childhood psychopathology: A summary" - In reply
SO PEDIATRICS
LA English
DT Letter
ID FACILITATED COMMUNICATION; SCIENCE; AUTISM
C1 Emory Univ, Dept Psychol, Atlanta, GA 30322 USA.
RP Lilienfeld, SO (reprint author), Emory Univ, Dept Psychol, Atlanta, GA 30322 USA.
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NR 20
TC 1
Z9 1
PU AMER ACAD PEDIATRICS
PI ELK GROVE VILLAGE
PA 141 NORTH-WEST POINT BLVD,, ELK GROVE VILLAGE, IL 60007-1098 USA
SN 0031-4005
EI 1098-4275
J9 PEDIATRICS
JI Pediatrics
PD JUL
PY 2005
VL 116
IS 1
BP 290
EP 292
DI 10.1542/peds.2005-0819
PG 3
WC Pediatrics
SC Pediatrics
GA 941IC
UT WOS:000230207500077
ER
PT J
AU Laidler, JR
AF Laidler, JR
TI US Department of Education Data on "Autism" are not reliable for
tracking autism prevalence
SO PEDIATRICS
LA English
DT Article
DE autism; prevalence; education
ID FRAGILE-X-SYNDROME; TUBEROUS SCLEROSIS; SPECTRUM DISORDER; POPULATION;
CHILDREN; PSYCHOPATHOLOGY; DIAGNOSIS
AB Many autism advocacy groups use the data collected by the US Department of Education (USDE) to show a rapidly increasing prevalence of autism. Closer examination of these data to follow each birth- year cohort reveals anomalies within the USDE data on autism. The USDE data show not only a rise in overall autism prevalence with time but also a significant and nearly linear rise in autism prevalence within a birth- year cohort as it ages, with significant numbers of new cases as late as 17 years of age. In addition, an unexpected reduction in the rise of autism prevalence occurs in most cohorts at 12 years of age, the age when most children would be entering middle school. These anomalies point to internal problems in the USDE data that make them unsuitable for tracking autism prevalence.
C1 Portland State Univ, Dept Biol, Portland, OR 97207 USA.
RP Laidler, JR (reprint author), Portland State Univ, Dept Biol, POB 751, Portland, OR 97207 USA.
EM laidlerj@pdx.edu
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NR 19
TC 15
Z9 16
PU AMER ACAD PEDIATRICS
PI ELK GROVE VILLAGE
PA 141 NORTH-WEST POINT BLVD,, ELK GROVE VILLAGE, IL 60007-1098 USA
SN 0031-4005
J9 PEDIATRICS
JI Pediatrics
PD JUL
PY 2005
VL 116
IS 1
BP E120
EP E124
DI 10.1542/peds.2004-2341
PG 5
WC Pediatrics
SC Pediatrics
GA 941IC
UT WOS:000230207500018
PM 15995012
ER
PT J
AU Alberto, PA
Cihak, DF
Gama, RI
AF Alberto, PA
Cihak, DF
Gama, RI
TI Use of static picture prompts versus video modeling during simulation
instruction
SO RESEARCH IN DEVELOPMENTAL DISABILITIES
LA English
DT Article
DE static picture prompts; video modelling; classroom simulation strategies
ID COMMUNITY-BASED INSTRUCTION; MENTAL-RETARDATION; PURCHASING SKILLS;
STUDENTS; CHILDREN; ACQUISITION; AUTISM; ADULTS
AB The purpose of this study was to compare the effectiveness and efficiency of static picture prompts and video modeling as classroom simulation strategies in combination with in vivo community instruction. Students with moderate intellectual disabilities were instructed in the tasks of withdrawing money from an ATM and purchasing items using a debit card. Both simulation strategies were effective and efficient at teaching the skills. The two simulation strategies were not functionally different in terms of number of trials to acquisition, number of errors, and number of instructional sessions to criterion. (c) 2004 Elsevier Ltd All rights reserved.
C1 Georgia State Univ & Special Educ, Dept Educ Psychol, Atlanta, GA 30303 USA.
RP Alberto, PA (reprint author), Georgia State Univ & Special Educ, Dept Educ Psychol, Univ Plaza, Atlanta, GA 30303 USA.
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NR 22
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Z9 32
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0891-4222
J9 RES DEV DISABIL
JI Res. Dev. Disabil.
PD JUL-AUG
PY 2005
VL 26
IS 4
BP 327
EP 339
DI 10.1016/j.ridd.2004.11.002
PG 13
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA 952YR
UT WOS:000231042900002
PM 15766627
ER
PT J
AU Howard, JS
Sparkman, CR
Cohen, HG
Green, G
Stanislaw, H
AF Howard, JS
Sparkman, CR
Cohen, HG
Green, G
Stanislaw, H
TI A comparison of intensive behavior analytic and eclectic treatments for
young children with autism
SO RESEARCH IN DEVELOPMENTAL DISABILITIES
LA English
DT Article; Proceedings Paper
CT Annual Meeting of the California-Association-for-Behavior-Analysis
CY FEB, 2003
CL San Francisco, CA
SP Calif Assoc Behav Anal
DE autism; early intervention; applied behavior analysis; eclectic
treatment; outcomes
ID EARLY INTERVENTION; MENTAL-RETARDATION; EARLY EXPERIENCE; RAT MODEL;
INTEGRATION; PREVALENCE; DISORDERS; DEPLETION; THERAPY; RISK
AB We compared the effects of three treatment approaches on preschool-age children with autism spectrum disorders. Twenty-nine children received intensive behavior analytic intervention (IBT; 1:1 adult:child ratio, 25-40 h per week). A comparison group (n = 16) received intensive "eclectic" intervention (a combination of methods, 1:1 or 1:2 ratio, 30 h per week) in public special education classrooms (designated the AP group). A second comparison group (GP) comprised 16 children in non-intensive public early intervention programs (a combination of methods, small groups, 15 h per week). Independent examiners administered standardized tests of cognitive, language, and adaptive skills to children in all three groups at intake and about 14 months after treatment began. The groups were similar on key variables at intake. At follow-up, the IBT group had higher mean standard scores in all skill domains than the AP and GP groups. The differences were statistically significant for all domains except motor skills. There were no statistically significant differences between the mean scores of the AP and GP groups. Learning rates at follow-up were also substantially higher for children in the IBT group than for either of the other two groups. These findings are consistent with other research showing that IBT is considerably more efficacious than "eclectic" intervention. (c) 2005 Elsevier Ltd. All rights reserved.
C1 Calif State Univ Stanislaus, Dept Psychol, Turlock, CA 95382 USA.
Kendall Sch, Modesto, CA 95354 USA.
Valley Mt Reg Ctr, Stockton, CA 95269 USA.
Univ N Texas, Denton, TX 76203 USA.
San Diego State Univ, San Diego, CA 92182 USA.
RP Howard, JS (reprint author), Calif State Univ Stanislaus, Dept Psychol, 801 W Monte Vista Ave, Turlock, CA 95382 USA.
EM jhoward@athena.csustan.edu
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NR 74
TC 188
Z9 191
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0891-4222
J9 RES DEV DISABIL
JI Res. Dev. Disabil.
PD JUL-AUG
PY 2005
VL 26
IS 4
BP 359
EP 383
DI 10.1016/j.ridd.2004.09.005
PG 25
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA 952YR
UT WOS:000231042900004
PM 15766629
ER
PT J
AU Taylor, BA
Hoch, H
Potter, B
Rodriguez, A
Spinnato, D
Kalaigian, M
AF Taylor, BA
Hoch, H
Potter, B
Rodriguez, A
Spinnato, D
Kalaigian, M
TI Manipulating establishing operations to promote initiations toward peers
in children with autism
SO RESEARCH IN DEVELOPMENTAL DISABILITIES
LA English
DT Article
DE establishing operations; mand training; autism; initiations
ID TIME-DELAY
AB This study examined the effects of manipulating establishing operations on the frequency of initiations of three children with autism toward peers with autism. The EO targeted was deprivation of preferred edibles, and the target initiation was a mand for the preferred snack. A reversal design was used to assess the effects of the EO conditions on frequency of initiations. Results indicated that when the EO was absent, no spontaneous initiations toward the peer occurred. Two participants required training sessions with an adult to transfer initiations toward peers. Once the EO had been established and was present, the participants initiated mands for the snack. Results are discussed in terms of implications for the use of establishing operations in language training for children with autism. (c) 2005 Elsevier Ltd All rights reserved.
C1 Alpine Learning Grp, Paramus, NJ 07652 USA.
CUNY, Grad Ctr, New York, NY USA.
RP Taylor, BA (reprint author), Alpine Learning Grp, 777 Paramus Rd, Paramus, NJ 07652 USA.
EM algbt@opcenter.net
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NR 12
TC 12
Z9 12
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0891-4222
J9 RES DEV DISABIL
JI Res. Dev. Disabil.
PD JUL-AUG
PY 2005
VL 26
IS 4
BP 385
EP 392
DI 10.1016/j.ridd.2004.11.003
PG 8
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA 952YR
UT WOS:000231042900005
PM 15766630
ER
PT J
AU Wickelgren, A
AF Wickelgren, A
TI Autistic brains out of synch?
SO SCIENCE
LA English
DT News Item
AB This article investigates if autism stems from abnormal communication between different brain regions?
NR 0
TC 4
Z9 4
PU AMER ASSOC ADVANCEMENT SCIENCE
PI WASHINGTON
PA 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA
SN 0036-8075
J9 SCIENCE
JI Science
PD JUN 24
PY 2005
VL 308
IS 5730
BP 1856
EP 1858
PG 3
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 940BZ
UT WOS:000230120000010
ER
PT J
AU Trivedi, B
AF Trivedi, B
TI Autistic and proud
SO NEW SCIENTIST
LA English
DT Article
AB To some sufferers autism is not a disease that needs curing, but a form of neurodiversity that they hope will gain social acceptance. These are the beliefs behind the first Autistic Pride Day.
NR 0
TC 1
Z9 1
PU REED BUSINESS INFORMATION LTD
PI SUTTON
PA QUADRANT HOUSE THE QUADRANT, SUTTON SM2 5AS, SURREY, ENGLAND
SN 0262-4079
J9 NEW SCI
JI New Sci.
PD JUN 18
PY 2005
VL 186
IS 2504
BP 36
EP 40
PG 5
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 937KK
UT WOS:000229922800041
ER
PT J
AU Lopez-Pison, J
Rubio-Rubio, R
Urena-Hornos, T
Omenaca-Teres, M
Sans, A
de Diago, RC
Pena-Segura, JL
AF Lopez-Pison, J
Rubio-Rubio, R
Urena-Hornos, T
Omenaca-Teres, M
Sans, A
de Diago, RC
Pena-Segura, JL
TI Retrospective diagnosis of congenital infection by cytomegalovirus in
the case of one infant
SO REVISTA DE NEUROLOGIA
LA Spanish
DT Article
DE autism; congenital cytomegalovirus; leukoeucephalopathy; malformation of
the hippocampus; malformation of the temporal lobe; mental retardation;
microcephalus; PCR
ID POLYMERASE-CHAIN-REACTION; TEMPORAL-LOBE EPILEPSY; GUTHRIE CARDS; DNA
DETECTION; ABNORMALITIES
AB Introduction. 10-15% of asymptomatic congenital infections by cytomegalovirus (CMV) in the neonatal period develop persistent problems with varying degrees of severity, fundamentally involving neurological disorders, neurosensory hypoacusis and hypovision, which appear from the age of 6-9 months onwards, when a diagnosis is no longer possible. The PCR (polymerase chain reaction) technique can detect DNA of CMV in blood samples on filter paper used for screening hypothyroidism and metabolic pathologies that were kept from the neonatal period. Case report. A child aged 3 years and 8 months with delayed intrauterine growth, autism, mental retardation, microcephalus and neurosensory hypoacusis; periventricular calcifications, leukoencephalopathy and bilateral malformation of the temporal lobe; and a diagnosis of congenital CMV confirmed by detection of DNA by PCR in the blood sample on filter paper saved from the neonatal period. Conclusions. The retrospective study of congenital infection by CMV should be considered when faced with severity and varying association of delayed intrauterine growth, microcephalus, neurosensory hypoacusis, chorioretinitis, mental retardation, autism or other behavioural disorders, intracranial calcifications, encephaloclastic alterations, leukoencephalopathy, cortical dysplasia and malformations of the temporal lobe and the hippocampus. Since the filter papers from neonatal screening are not kept for ever, perhaps the idea of doing so ought to be considered, given the possibilities they offer for retrospective studies.
C1 Hosp Univ Miguel Servet, Secc Neuropediat, Serv Pediat, E-50009 Zaragoza, Spain.
Hosp Univ Miguel Servet, Microbiol Serv, E-50009 Zaragoza, Spain.
Hosp Sant Joan de Deu, Neurol Serv, Barcelona, Spain.
RP Lopez-Pison, J (reprint author), Hosp Univ Miguel Servet, Secc Neuropediat, Serv Pediat, Paseo Isabel la Catolica 1-3, E-50009 Zaragoza, Spain.
EM jlopezpi@salud.aragon.es
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NR 16
TC 8
Z9 8
PU REVISTA DE NEUROLOGIA
PI BARCELONA
PA C/O CESAR VIGUERA, EDITOR, APDO 94121, 08080 BARCELONA, SPAIN
SN 0210-0010
J9 REV NEUROLOGIA
JI Rev. Neurologia
PD JUN 16
PY 2005
VL 40
IS 12
BP 733
EP 736
PG 4
WC Clinical Neurology
SC Neurosciences & Neurology
GA 950KP
UT WOS:000230856300006
PM 15973639
ER
PT J
AU Seeman, C
AF Seeman, C
TI Succeeding with autism: Hear my voice.
SO LIBRARY JOURNAL
LA English
DT Book Review
C1 Univ Toledo Libs, Toledo, OH USA.
RP Seeman, C (reprint author), Univ Toledo Libs, Toledo, OH USA.
CR COHEN JH, 2005, SUCCEEDING AUTISM HE
NR 1
TC 0
Z9 0
PU BOWKER MAGAZINE GROUP CAHNERS MAGAZINE DIVISION
PI NEW YORK
PA 249 W 17TH ST, NEW YORK, NY 10011 USA
SN 0363-0277
J9 LIBR J
JI Libr. J.
PD JUN 15
PY 2005
VL 130
IS 11
BP 85
EP 85
PG 1
WC Information Science & Library Science
SC Information Science & Library Science
GA 936VY
UT WOS:000229884700159
ER
PT J
AU Chubykin, AA
Liu, XR
Comoletti, D
Tsigelny, I
Taylor, P
Sudhof, TC
AF Chubykin, AA
Liu, XR
Comoletti, D
Tsigelny, I
Taylor, P
Sudhof, TC
TI Dissection of synapse induction by neuroligins - Effect of a neuroligin
mutation associated with autism
SO JOURNAL OF BIOLOGICAL CHEMISTRY
LA English
DT Article
ID ALPHA-LATROTOXIN RECEPTORS; CELL-SURFACE PROTEINS; NEUREXIN I-ALPHA;
EXCITATORY SYNAPSES; ADHESION MOLECULES; QUALITY-CONTROL;
BETA-NEUREXINS; F-ACTIN; BINDING; GENES
AB To study synapse formation by neuroligins, we cocultured hippocampal neurons with COS cells expressing wild type and mutant neuroligins. The large size of COS cells makes it possible to test the effect of neuroligins presented over an extended surface area. We found that a uniform lawn of wild type neuroligins displayed on the cell surface triggers the formation of hundreds of uniformly sized, individual synaptic contacts that are labeled with neurexin antibodies. Electron microscopy revealed that these artificial synapses contain a presynaptic active zone with docked vesicles and often feature a postsynaptic density. Neuroligins 1, 2, and 3 were active in this assay. Mutations in two surface loops of neuroligin 1 abolished neuroligin binding to neurexin 1β, a presumptive presynaptic binding partner for postsynaptic neuroligins, and blocked synapse formation. An analysis of mutant neuroligins with an amino acid substitution that corresponds to a mutation described in patients with an autistic syndrome confirmed previous reports that these mutant neuroligins have a compromised capacity to be transported to the cell surface. Nevertheless, the small percentage of mutant neuroligins that reached the cell surface still induced synapse formation. Viewed together, our data suggest that neuroligins generally promote artificial synapse formation in a manner that is associated with β-neurexin binding and results in morphologically well differentiated synapses and that a neuroligin mutation found in autism spectrum disorders impairs cell-surface transport but does not completely abolish synapse formation activity.
C1 Univ Texas, SW Med Ctr, Ctr Basic Neurosci, Dallas, TX 75390 USA.
Univ Texas, SW Med Ctr, Dept Mol Genet, Dallas, TX 75390 USA.
Univ Texas, SW Med Ctr, Howard Hughes Med Inst, Dallas, TX 75390 USA.
Univ Calif San Diego, Dept Pharmacol, La Jolla, CA 92093 USA.
RP Sudhof, TC (reprint author), Univ Texas, SW Med Ctr, Ctr Basic Neurosci, NA4-118,6000 Harry Hines Blvd, Dallas, TX 75390 USA.
EM Thomas.Sudhof@UTSouthwestern.edu
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TC 101
Z9 104
PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3996 USA
SN 0021-9258
J9 J BIOL CHEM
JI J. Biol. Chem.
PD JUN 10
PY 2005
VL 280
IS 23
BP 22365
EP 22374
DI 10.1074/jbc.M410723200
PG 10
WC Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA 932MN
UT WOS:000229557900082
PM 15797875
ER
PT J
AU Wu, SP
Guo, YQ
Jia, MX
Ruan, Y
Shuang, M
Liu, J
Gong, XH
Zhang, YB
Yang, JZ
Yang, XL
Zhang, D
AF Wu, SP
Guo, YQ
Jia, MX
Ruan, Y
Shuang, M
Liu, J
Gong, XH
Zhang, YB
Yang, JZ
Yang, XL
Zhang, D
TI Lack of evidence for association between the serotonin transporter gene
(SLC6A4) polymorphisms and autism in the Chinese trios
SO NEUROSCIENCE LETTERS
LA English
DT Article
DE autism; serotonin transporter gene (SLC6A4); single nucleotide
polymorphism (SNP); the transmission disequilibrium test (TDT);
haplotype analysis
ID WHOLE-BLOOD SEROTONIN; OBSESSIVE-COMPULSIVE DISORDER; LINKAGE
DISEQUILIBRIUM; GENOMEWIDE SCREEN; TRANSMISSION; VARIANTS; FAMILIES;
REGION; RELATIVES; CHILDREN
AB Serotonin regulates several aspects of brain development, and it is involved in a range of behaviors frequently disturbed in autistic disorder. The serotonin transporter is a critical component of the serotonergic system. The serotonin transporter gene (SLC6A4) is of special interest given the nature of the biological findings and the reported effects of selective serotonin reuptake inhibitors of autistic Symptoms. So far the genetics researches of the SLC6A4 gene have given conflicting results. The aim of study was to investigate the association between the SLC6A4 gene and autism in the Chinese Han population. The present study was conducted with the detection of three single nucleotide polymorphisms (SNPs) located within the SLC6A4 gene by using the polymerase chain reaction-restriction fragment length polymorphisms (PCR-RFLP) analysis. We performed a family-based association study of these polymorphisms in 175 Chinese Han family trios. Linkage disequilibrium (LD) measurement (D ') analysis showed the presence of LD between markers across the locus. No significant evidence of association was found at any of the markers detected by using the transmission disequilibrium test (TDT) and haplotype analyses in all samples and male samples. Our findings suggest that it is unlikely that DNA variations in the SLC6A4 gene play a significant role in the genetic predisposition to autism in the Chinese Han population or that allelic heterogeneity at the SLC6A4 loci dilutes potential disease-allele association. (c) 2005 Elsevier Ireland Ltd. All rights reserved.
C1 Peking Univ, Inst Mental Hlth, Dept Biochem, Beijing 100083, Peoples R China.
RP Zhang, D (reprint author), Peking Univ, Inst Mental Hlth, Dept Biochem, 51 Hua Yuan Bei Rd, Beijing 100083, Peoples R China.
EM yangxl@public.fhnet.cn.net; daizhang@bjmu.edu.cn
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NR 27
TC 12
Z9 14
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
IRELAND
SN 0304-3940
J9 NEUROSCI LETT
JI Neurosci. Lett.
PD JUN 10
PY 2005
VL 381
IS 1-2
BP 1
EP 5
DI 10.1016/j.neulet.2005.01.073
PG 5
WC Neurosciences
SC Neurosciences & Neurology
GA 930BI
UT WOS:000229390400001
PM 15882779
ER
PT J
AU Splawski, I
Timothy, KW
Decher, N
Kumar, P
Sachse, FB
Beggs, AH
Sanguinetti, MC
Keating, MT
AF Splawski, I
Timothy, KW
Decher, N
Kumar, P
Sachse, FB
Beggs, AH
Sanguinetti, MC
Keating, MT
TI Severe arrhythmia disorder caused by cardiac L-type calcium channel
mutations
SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF
AMERICA
LA English
DT Article
DE long QT syndrome; Timothy syndrome; CACNA1C
ID HUMAN GENETIC-DISEASE; XENOPUS-OOCYTES; ION CHANNELS; HEART-CELLS;
EXPRESSION; SUBUNITS; CURRENTS; MODEL
AB Timothy syndrome (TS) is a multisystem disorder that causes syncope and sudden death from cardiac arrhythmias. Prominent features include congenital heart disease, immune deficiency, intermittent hypoglycemia, cognitive abnormalities, and autism. All TS individuals have syndactyly (webbing of fingers and toes). We discovered that TS resulted from a recurrent, de novo cardiac L-type calcium channel (Ca(v)1.2) mutation, G406R. G406 is located in alternatively spliced exon 8A, encoding transmembrane segment S6 of domain I. Here, we describe two individuals with a severe variant of TS (TS2). Neither child had syndactyly. Both individuals had extreme prolongation of the QT interval on electrocardiogram, with a QT interval corrected for heart rate ranging from 620 to 730 ms, causing multiple arrhythmias and sudden death. One individual had severe mental retardation and nemaline rod skeletal myopathy. We identified de novo missense mutations in exon 8 of Cav1.2 in both individuals. One was an analogous mutation to that found in exon 8A in classic TS, G406R. The other mutation was G402S. Exon 8 encodes the same region as exon 8A, and the two are mutually exclusive. The spliced form of Cav1.2 containing exon 8 is highly expressed in heart and brain, accounting for approximate to 80% of Cav1.2 mRNAs. G406R and G402S cause reduced channel inactivation, resulting in maintained depolarizing L-type calcium currents. Computer modeling showed prolongation of cardiomyocyte action potentials and delayed afterdepolarizations, factors that increase risk of arrhythmia. These data indicate that gain-of-function mutations of Cav1.2 exons 8 and 8A cause distinct forms of TS.
C1 Childrens Hosp, Howard Hughes Med Inst, Boston, MA 02115 USA.
Childrens Hosp, Dept Cardiol, Boston, MA 02115 USA.
Childrens Hosp, Genom Program, Boston, MA 02115 USA.
Childrens Hosp, Div Genet, Boston, MA 02115 USA.
Harvard Univ, Sch Med, Dept Pediat, Boston, MA 02115 USA.
Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA.
Univ Utah, Nora Eccles Harrison Cardiovasc Res & Training In, Salt Lake City, UT 84112 USA.
Univ Utah, Dept Physiol, Salt Lake City, UT 84112 USA.
Univ Utah, Dept Engn, Salt Lake City, UT 84112 USA.
RP Splawski, I (reprint author), Childrens Hosp, Howard Hughes Med Inst, 300 Longwood Ave, Boston, MA 02115 USA.
EM igor@enders.tch.harvard.edu
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NR 23
TC 228
Z9 241
PU NATL ACAD SCIENCES
PI WASHINGTON
PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA
SN 0027-8424
J9 P NATL ACAD SCI USA
JI Proc. Natl. Acad. Sci. U. S. A.
PD JUN 7
PY 2005
VL 102
IS 23
BP 8089
EP 8096
DI 10.1073/pnas.0502506102
PG 8
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 933RL
UT WOS:000229650500006
PM 15863612
ER
PT J
AU Kagan, J
Pozen, R
AF Kagan, J
Pozen, R
TI Autism inflation
SO FORBES
LA English
DT Editorial Material
AB Doctors should use biology, not only behavior, to evaluate children.
C1 Harvard Univ, Cambridge, MA 02138 USA.
RP Kagan, J (reprint author), Harvard Univ, Cambridge, MA 02138 USA.
NR 0
TC 0
Z9 0
PU FORBES INC
PI NEW YORK
PA 60 FIFTH AVE, NEW YORK, NY 10011 USA
SN 0015-6914
J9 FORBES
JI Forbes
PD JUN 6
PY 2005
VL 175
IS 12
BP 44
EP 44
PG 1
WC Business, Finance
SC Business & Economics
GA 928ZU
UT WOS:000229311500008
ER
PT J
AU Hertz-Picciotto, I
Croen, L
Hansen, R
AF Hertz-Picciotto, I
Croen, L
Hansen, R
TI What is the evidence that environmental factors contribute to autism?
SO AMERICAN JOURNAL OF EPIDEMIOLOGY
LA English
DT Meeting Abstract
CT Joint Meeting of the
Society-for-Epidemiologic-Research/Canadian-Society-for-Epidemiology-and
-Biostatistics
CY JUN 27-30, 2005
CL Toronto, CANADA
SP Soc Epidemiol Res, Canadian Soc Epidemiol & Biostat
C1 Univ Calif Davis, MIND Inst, Davis, CA 95616 USA.
Univ Calif Davis, Dept Publ Hlth Sci, Davis, CA 95616 USA.
NR 0
TC 0
Z9 0
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0002-9262
J9 AM J EPIDEMIOL
JI Am. J. Epidemiol.
PD JUN 1
PY 2005
VL 161
IS 11
SU S
BP S114
EP S114
PG 1
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 932ZS
UT WOS:000229594100452
ER
PT J
AU Lee, LC
Newschaffer, CJ
Harrington, RA
Landa, R
AF Lee, LC
Newschaffer, CJ
Harrington, RA
Landa, R
TI Growth trajectory of head circumference in siblings of children with
autism spectrum disorders.
SO AMERICAN JOURNAL OF EPIDEMIOLOGY
LA English
DT Meeting Abstract
CT Joint Meeting of the
Society-for-Epidemiologic-Research/Canadian-Society-for-Epidemiology-and
-Biostatistics
CY JUN 27-30, 2005
CL Toronto, CANADA
SP Soc Epidemiol Res, Canadian Soc Epidemiol & Biostat
C1 Johns Hopkins Univ, Ctr Autism & Dev Disabilities Epidemiol, Baltimore, MD 21205 USA.
NR 0
TC 0
Z9 0
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0002-9262
J9 AM J EPIDEMIOL
JI Am. J. Epidemiol.
PD JUN 1
PY 2005
VL 161
IS 11
SU S
BP S111
EP S111
PG 1
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 932ZS
UT WOS:000229594100441
ER
PT J
AU Barnby, G
Abbott, A
Sykes, N
Morris, A
Weeks, DE
Mott, R
Lamb, J
Bailey, AJ
Monaco, AP
AF Barnby, G
Abbott, A
Sykes, N
Morris, A
Weeks, DE
Mott, R
Lamb, J
Bailey, AJ
Monaco, AP
CA IMGSAC
TI Candidate-gene screening and association analysis at the
autism-susceptibility locus on chromosome 16p: Evidence of association
at GRIN2A and ABAT
SO AMERICAN JOURNAL OF HUMAN GENETICS
LA English
DT Article
ID ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; PERVASIVE DEVELOPMENTAL
DISORDERS; LINKAGE DISEQUILIBRIUM; RHEUMATOID-ARTHRITIS; GENOMEWIDE
SCREEN; COMMON DISEASE; FOLLOW-UP; MUTATIONS; HAPLOTYPES; PEDIGREES
AB Autism is a highly heritable neurodevelopmental disorder whose underlying genetic causes have yet to be identified. To date, there have been eight genome screens for autism, two of which identified a putative susceptibility locus on chromosome 16p. In the present study, 10 positional candidate genes that map to 16p11-13 were examined for coding variants: A2BP1, ABAT, BFAR, CREBBP, EMP2, GRIN2A, MRTF-B, SSTR5, TBX6, and UBN1. Screening of all coding and regulatory regions by denaturing high-performance liquid chromatography identified seven non-synonymous changes. Five of these mutations were found to cosegregate with autism, but the mutations are not predicted to have deleterious effects on protein structure and are unlikely to represent significant etiological variants. Selected variants from candidate genes were genotyped in the entire International Molecular Genetics Study of Autism Consortium collection of 239 multiplex families and were tested for association with autism by use of the pedigree disequilibrium test. Additionally, genotype frequencies were compared between 239 unrelated affected individuals and 192 controls. Patterns of linkage disequilibrium were investigated, and the transmission of haplotypes across candidate genes was tested for association. Evidence of single-marker association was found for variants in ABAT, CREBBP, and GRIN2A. Within these genes, 12 single-nucleotide polymorphisms (SNPs) were subsequently genotyped in 91 autism trios (one affected individual and two unaffected parents), and the association was replicated within GRIN2A (Fisher's exact test, P < .0001). Logistic regression analysis of SNP data across GRIN2A and ABAT showed a trend toward haplotypic differences between cases and controls.
C1 Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford OX3 7BN, England.
Pk Hosp Children, Univ Dept Psychiat, Sect Child & Adolescent Psychiat, Oxford, England.
Univ Pittsburgh, Grad Sch Publ Hlth, Dept Human Genet, Pittsburgh, PA 15261 USA.
Univ Pittsburgh, Grad Sch Publ Hlth, Dept Biostat, Pittsburgh, PA 15261 USA.
RP Monaco, AP (reprint author), Univ Oxford, Wellcome Trust Ctr Human Genet, Roosevelt Dr, Oxford OX3 7BN, England.
EM anthony.monaco@well.ox.ac.uk
RI Monaco, Anthony/A-4495-2010; Weeks, Daniel/B-2995-2012; Bolton,
Patrick/E-8501-2010; Bailey, Anthony/J-2860-2014
OI Monaco, Anthony/0000-0001-7480-3197; Bolton,
Patrick/0000-0002-5270-6262; Bailey, Anthony/0000-0003-4257-972X
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NR 64
TC 79
Z9 82
PU UNIV CHICAGO PRESS
PI CHICAGO
PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA
SN 0002-9297
J9 AM J HUM GENET
JI Am. J. Hum. Genet.
PD JUN
PY 2005
VL 76
IS 6
BP 950
EP 966
DI 10.1086/430454
PG 17
WC Genetics & Heredity
SC Genetics & Heredity
GA 925IX
UT WOS:000229047900004
PM 15830322
ER
PT J
AU Cantor, RM
Kono, N
Duvall, JA
Alvarez-Retuerto, A
Stone, JL
Alarcon, M
Nelson, SF
Geschwind, DH
AF Cantor, RM
Kono, N
Duvall, JA
Alvarez-Retuerto, A
Stone, JL
Alarcon, M
Nelson, SF
Geschwind, DH
TI Replication of autism linkage: Fine-mapping peak at 17q21
SO AMERICAN JOURNAL OF HUMAN GENETICS
LA English
DT Article
ID GENETIC RESOURCE EXCHANGE; WHOLE-BLOOD SEROTONIN; GENOMEWIDE SCREEN;
GENOMIC SCREEN; DISORDERS; ASSOCIATION; PRESSURE; LOCUS; 2Q
AB Autism is a heritable but genetically complex disorder characterized by deficits in language and in reciprocal social interactions, combined with repetitive and stereotypic behaviors. As with many genetically complex disorders, numerous genome scans reveal inconsistent results. A genome scan of 345 families from the Autism Genetic Resource Exchange (AGRE) (AGRE_1), gave the strongest evidence of linkage at 17q11-17q21 in families with no affected females. Here, we report a full-genome scan of an independent sample of 91 AGRE families with 109 affected sibling pairs (AGRE_2) that also shows the strongest evidence of linkage to 17q11-17q21 in families with no affected females. Taken together, these samples provide a replication of linkage to this chromosome region that is, to our knowledge, the first such replication in autism. Fine mapping at 2-centimorgan (cM) intervals in the combined sample of families with no affected females reveals a linkage peak at 66.85 cM, which places this locus at 17q21.
C1 Univ Calif Los Angeles, David Geffen Sch Med, Dept Human Genet, Los Angeles, CA 90095 USA.
Univ Calif Los Angeles, David Geffen Sch Med, Dept Pediat, Los Angeles, CA 90095 USA.
Univ Calif Los Angeles, David Geffen Sch Med, Ctr Autism Res, Los Angeles, CA 90095 USA.
Univ Calif Los Angeles, David Geffen Sch Med, Ctr Neurobehav Genet, Inst Neuropsychiat, Los Angeles, CA 90095 USA.
Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurol, Program Neurogenet, Los Angeles, CA 90095 USA.
RP Cantor, RM (reprint author), Univ Calif Los Angeles, David Geffen Sch Med, Dept Human Genet, Los Angeles, CA 90095 USA.
EM rcantor@mednet.ucla.edu
RI Nelson, Stanley/D-4771-2009
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
[Anonymous], 1992, INT STAT CLASS DIS R
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NR 32
TC 95
Z9 101
PU UNIV CHICAGO PRESS
PI CHICAGO
PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA
SN 0002-9297
J9 AM J HUM GENET
JI Am. J. Hum. Genet.
PD JUN
PY 2005
VL 76
IS 6
BP 1050
EP 1056
DI 10.1086/430278
PG 7
WC Genetics & Heredity
SC Genetics & Heredity
GA 925IX
UT WOS:000229047900010
PM 15877280
ER
PT J
AU MacDermot, KD
Bonora, E
Sykes, N
Coupe, AM
Lai, CSL
Vernes, SC
Vargha-Khadem, F
McKenzie, F
Smith, RL
Monaco, AP
Fisher, SE
AF MacDermot, KD
Bonora, E
Sykes, N
Coupe, AM
Lai, CSL
Vernes, SC
Vargha-Khadem, F
McKenzie, F
Smith, RL
Monaco, AP
Fisher, SE
TI Identification of FOXP2 truncation as a novel cause of developmental
speech and language deficits
SO AMERICAN JOURNAL OF HUMAN GENETICS
LA English
DT Article
ID TRANSCRIPTIONAL REPRESSORS; SUSCEPTIBILITY GENE; INHERITED SPEECH;
FORKHEAD-DOMAIN; EXPRESSION; DISORDER; BRAIN; IMPAIRMENT; MUTATIONS;
EVOLUTION
AB FOXP2, the first gene to have been implicated in a developmental communication disorder, offers a unique entry point into neuromolecular mechanisms influencing human speech and language acquisition. In multiple members of the well-studied KE family, a heterozygous missense mutation in FOXP2 causes problems in sequencing muscle movements required for articulating speech ( developmental verbal dyspraxia), accompanied by wider deficits in linguistic and grammatical processing. Chromosomal rearrangements involving this locus have also been identified. Analyses of FOXP2 coding sequence in typical forms of specific language impairment (SLI), autism, and dyslexia have not uncovered any etiological variants. However, no previous study has performed mutation screening of children with a primary diagnosis of verbal dyspraxia, the most overt feature of the disorder in affected members of the KE family. Here, we report investigations of the entire coding region of FOXP2, including alternatively spliced exons, in 49 probands affected with verbal dyspraxia. We detected variants that alter FOXP2 protein sequence in three probands. One such variant is a heterozygous nonsense mutation that yields a dramatically truncated protein product and cosegregates with speech and language difficulties in the proband, his affected sibling, and their mother. Our discovery of the first nonsense mutation in FOXP2 now opens the door for detailed investigations of neurodevelopment in people carrying different etiological variants of the gene. This endeavor will be crucial for gaining insight into the role of FOXP2 in human cognition.
C1 Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford OX3 7BN, England.
Univ London Imperial Coll Sci & Technol, Dept Med & Community Genet, London, England.
UCL, Inst Child Hlth, Dev Cognit Neurosci Unit, London, England.
John Hunter Childrens Hosp Genet & Neurol, Waratah, Australia.
RP Fisher, SE (reprint author), Univ Oxford, Wellcome Trust Ctr Human Genet, Roosevelt Dr, Oxford OX3 7BN, England.
EM simon.fisher@well.ox.ac.uk
RI Monaco, Anthony/A-4495-2010; Vargha-Khadem, Faraneh/C-2558-2008; Fisher,
Simon/E-9130-2012; Vernes, Sonja/E-8454-2012
OI Monaco, Anthony/0000-0001-7480-3197; Fisher, Simon/0000-0002-3132-1996;
Vernes, Sonja/0000-0003-0305-4584
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NR 36
TC 189
Z9 195
PU CELL PRESS
PI CAMBRIDGE
PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA
SN 0002-9297
J9 AM J HUM GENET
JI Am. J. Hum. Genet.
PD JUN
PY 2005
VL 76
IS 6
BP 1074
EP 1080
DI 10.1086/430841
PG 7
WC Genetics & Heredity
SC Genetics & Heredity
GA 925IX
UT WOS:000229047900013
PM 15877281
ER
PT J
AU Miles, JH
Takahashi, TN
Bagby, S
Sahota, PK
Vaslow, DF
Wang, CH
Hillman, RE
Farmer, JE
AF Miles, JH
Takahashi, TN
Bagby, S
Sahota, PK
Vaslow, DF
Wang, CH
Hillman, RE
Farmer, JE
TI Essential versus complex autism: Definition of fundamental prognostic
subtypes
SO AMERICAN JOURNAL OF MEDICAL GENETICS PART A
LA English
DT Article
DE autism; essential; dysmorphology; head circumference; outcome
ID MINOR PHYSICAL ANOMALIES; PERVASIVE DEVELOPMENTAL DISORDERS; FAMILY
HISTORY METHOD; CHILDHOOD AUTISM; COGNITIVE DEFICITS; MULTIPLEX
FAMILIES; HEAD CIRCUMFERENCE; BROADER PHENOTYPE; ASPERGER-SYNDROME;
CHILDREN
AB Heterogeneity within the autism diagnosis obscures the genetic basis of the disorder and impedes our ability to develop effective treatments. We found that by using two readily available tests, autism can be divided into two subgroups, "essential autism" and "complex autism," with different outcomes and recurrence risks. Complex autism consists of individuals in whom there is evidence of some abnormality of early morphogenesis, manifested by either significant dysmorphology or microcephaly. The remainder have "essential autism." From 1995 to 2001, 260 individuals who met DSM-IV criteria for autistic disorder were examined. Five percent (13/260) were microcephalic and 16% (41/260) had significant physical anomalies. Individually, each trait predicted a poorer outcome. Together they define the "complex autism" subgroup, comprising 20% (46/233) of the total autism population. Individuals with complex autism have lower IQs (P = 0.006), more seizures (P = 0.0008), more abnormal EEGs (46% vs. 30%), more brain abnormalities by MRI (28% vs. 13%). Everyone with an identifiable syndrome was in the complex group. Essential autism defines the more heritable group with higher sib recurrence (4% vs. 0%), more relatives with autism (20% vs. 9%), and higher male to female ratio (6.5:1 vs. 3.2:1). Their outcome was better with higher IQs (P = 0.02) and fewer seizures (P = 0.0008). They were more apt to develop autism with a regressive onset (43% vs. 23%, P = 0.02). Analysis of the features predictive of poor outcome (IQ < 55, functionally non-verbal) showed that microcephaly was 100% specific but only 14% sensitive; the presence of physical anomalies was 86% specific and 34% sensitive. The two tests combined yielded 87% specificity, 47% sensitivity, and an odds ratio of 4.8:1 for poor outcome. Separating essential from complex autism should be the first diagnostic step for children with autism spectrum disorders as it allows better prognostication and counseling. Definition of more homogeneous. populations should increase power of research analyses. (c) 2005 Wiley-Liss, Inc.
C1 Univ Missouri, Childrens Hosp, Div Med Genet, Columbia, MO 65212 USA.
RP Miles, JH (reprint author), Univ Missouri, Childrens Hosp, Div Med Genet, 1 Hosp Dr, Columbia, MO 65212 USA.
EM milesjh@missouri.edu
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NR 100
TC 89
Z9 93
PU WILEY-LISS
PI HOBOKEN
PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 1552-4825
J9 AM J MED GENET A
JI Am. J. Med. Genet. A
PD JUN 1
PY 2005
VL 135A
IS 2
BP 171
EP 180
DI 10.1002/ajmg.a.30590
PG 10
WC Genetics & Heredity
SC Genetics & Heredity
GA 931LY
UT WOS:000229488000012
PM 15887228
ER
PT J
AU Chakrabarti, S
Fombonne, E
AF Chakrabarti, S
Fombonne, E
TI Pervasive developmental disorders in preschool children: Confirmation of
high prevalence
SO AMERICAN JOURNAL OF PSYCHIATRY
LA English
DT Article
ID AUTISM DIAGNOSTIC INTERVIEW; ABNORMALITIES; EPIDEMIOLOGY; POPULATION;
INSTRUMENT
AB Objective: The rate of reported pervasive developmental disorders has increased, and the authors found a rate of 62.6 per 10,000 in a previous study of preschoolers in Stafford, U. K. They conducted another survey in 2002 to estimate the prevalence in children in a later birth cohort and to compare it to previous findings from the same area.
Method: Screening for developmental problems included 10,903 children ages 4.0 to 6.0 years who were living in a Midlands town on the survey date. Children with symptoms suggestive of pervasive developmental disorders were intensively assessed by a multidisciplinary team using standardized diagnostic interviews, psychometric tests, and medical workups.
Results: Sixty-four children (85.9% boys) were diagnosed with pervasive developmental disorders. The prevalence was 58.7 per 10,000, with a 95% confidence interval (CI) of 45.2-74.9, for all pervasive developmental disorders, 22.0 per 10,000 (95% CI = 14.1-32.7) for autistic disorder, and 36.7 per 10,000 (95% CI = 26.2-49.9) for other variants. These rates were not significantly different from the previous rates. The mean age at diagnosis was 37.8 months, and 53.1% of the children were originally referred by health visitors. Of the 64 children with pervasive developmental disorders, 29.8% had mental retardation, but this rate varied by disorder subtype. Few children had associated medical conditions.
Conclusions: The rate of pervasive developmental disorders is higher than reported 15 years ago. The rate in this study is comparable to that in previous birth cohorts from the same area and surveyed with the same methods, suggesting a stable incidence.
C1 Montreal Childrens Hosp, Dept Psychiat, Montreal, PQ H3Z 1P2, Canada.
Cent Clin, Child Dev Ctr, Stafford, England.
McGill Univ, Dept Psychiat, Montreal, PQ, Canada.
RP Fombonne, E (reprint author), Montreal Childrens Hosp, Dept Psychiat, 4018 Ste Catherine W, Montreal, PQ H3Z 1P2, Canada.
EM eric.fombonne@mcgill.ca
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NR 24
TC 339
Z9 350
PU AMER PSYCHIATRIC PUBLISHING, INC
PI ARLINGTON
PA 1000 WILSON BOULEVARD, STE 1825, ARLINGTON, VA 22209-3901 USA
SN 0002-953X
J9 AM J PSYCHIAT
JI Am. J. Psychiat.
PD JUN
PY 2005
VL 162
IS 6
BP 1133
EP 1141
DI 10.1176/appi.ajp.162.6.1133
PG 9
WC Psychiatry
SC Psychiatry
GA 931SA
UT WOS:000229504300015
PM 15930062
ER
PT J
AU McDougle, CJ
Hollway, J
Scahill, L
Koenig, K
Aman, MG
McGough, JJ
McCracken, JT
Ritz, L
Tierney, E
Vitiello, B
Davies, M
Arnold, LE
Posey, DJ
Martin, A
Ghuman, JK
Shah, B
Chuang, SZ
Swiezy, NB
Gonzalez, NM
AF McDougle, CJ
Hollway, J
Scahill, L
Koenig, K
Aman, MG
McGough, JJ
McCracken, JT
Ritz, L
Tierney, E
Vitiello, B
Davies, M
Arnold, LE
Posey, DJ
Martin, A
Ghuman, JK
Shah, B
Chuang, SZ
Swiezy, NB
Gonzalez, NM
TI Risperidone for the core symptom domains of autism: Results from the
study by the autism network of the research units on pediatric
psychopharmacology
SO AMERICAN JOURNAL OF PSYCHIATRY
LA English
DT Article
ID PERVASIVE DEVELOPMENTAL DISORDERS; OBSESSIVE-COMPULSIVE DISORDER;
DOUBLE-BLIND; DIAGNOSTIC INTERVIEW; CLINICAL-TRIALS; RUPP AUTISM;
CHILDREN; SCALE; BEHAVIOR; HALOPERIDOL
AB Objective: Risperidone has been found efficacious for decreasing severe tantrums, aggression, and self-injurious behavior in children and adolescents with autistic disorder (autism). The authors report on whether risperidone improves the core symptoms of autism, social and communication impairment and repetitive and stereotyped behavior.
Method: The database from an 8-week double-blind, placebo-controlled trial (N = 101) and 16-week open-label continuation study (N = 63) of risperidone for children and adolescents with autism was used to test for drug effects on secondary outcome measures: scores on the Ritvo-Freeman Real Life Rating Scale, the Children's Yale-Brown Obsessive Compulsive Scale, and the maladaptive behavior domain of the Vineland Adaptive Behavior Scales.
Results: Compared to placebo, risperidone led to a significantly greater reduction in the overall score on the Ritvo-Freeman Real Life Rating Scale, as well as the scores on the subscales for sensory motor behaviors (subscale I), affectual reactions (subscale III), and sensory responses (subscale IV). No statistically significant difference was observed, however, on the subscale for social relatedness (subscale II) or language (subscale V). Risperidone also resulted in significantly greater reductions in scores on the Children's Yale-Brown Obsessive Compulsive Scale and Vineland maladaptive behavior domain. This pattern of treatment response was maintained for 6 months.
Conclusions: Risperidone led to significant improvements in the restricted, repetitive, and stereotyped patterns of behavior, interests, and activities of autistic children but did not significantly change their deficit in social interaction and communication. Further research is necessary to develop effective treatments for the core social and communicative impairments of autism.
C1 Indiana Univ, Sch Med, Dept Psychiat, Indianapolis, IN 46202 USA.
Johns Hopkins Univ, Kennedy Krieger Inst, Baltimore, MD USA.
Ohio State Univ, Nisonger Ctr, Columbus, OH 43210 USA.
Univ Calif Los Angeles, Tarjan Ctr, Los Angeles, CA 90024 USA.
Yale Univ, Ctr Child Study, New Haven, CT 06520 USA.
RP McDougle, CJ (reprint author), Indiana Univ, Sch Med, Dept Psychiat, PB A305,1111 W 10th St, Indianapolis, IN 46202 USA.
EM cmcdougl@iupui.edu
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IN PRESS AM J PSYCHI
NR 34
TC 171
Z9 172
PU AMER PSYCHIATRIC PUBLISHING, INC
PI ARLINGTON
PA 1000 WILSON BOULEVARD, STE 1825, ARLINGTON, VA 22209-3901 USA
SN 0002-953X
J9 AM J PSYCHIAT
JI Am. J. Psychiat.
PD JUN
PY 2005
VL 162
IS 6
BP 1142
EP 1148
DI 10.1176/appi.ajp.162.6.1142
PG 7
WC Psychiatry
SC Psychiatry
GA 931SA
UT WOS:000229504300016
PM 15930063
ER
PT J
AU Vickery, SS
Mason, GJ
AF Vickery, SS
Mason, GJ
TI Stereotypy and perseverative responding in caged bears: further data and
analyses
SO APPLIED ANIMAL BEHAVIOUR SCIENCE
LA English
DT Article
DE asiatic black bear; Malayan sun bear; perseveration; persistence;
stereotypy; striatal dysfunction
ID BEHAVIORAL DISINHIBITION; PECKING; MICE
AB Stereotypies are common in captive animals; yet, their underlying mechanisms are poorly understood. One hypothesis [Garner, J.P., 1999. The aetiology of stereotypy in caged animals. Ph.D. Thesis. University of Oxford, UK] proposes them to be symptoms of altered behavioural organisation (behavioural disinhibition) mediated by striatal dysfunction, and thus, fundamentally analogous to the repetitive behaviours associated with human pathologies such as schizophrenia and autism, or induced in animals by stimulant drugs and striatal lesions. Consistent with this, we previously showed stereotypy frequency to be positively correlated with inappropriate responding during the extinction phase of learning, a measure of `perseveration' consistent with striatal dysfunction, in caged bears [Vickery, S.S., Mason, G.J., 2003. Behavioral persistence in captive bears: implications for reintroduction. Ursus 14, 35-43]. Here, adding new data, we strengthen this finding and look for further evidence of striatal involvement. Twenty-one bears of two species (Asiatic black bears (Ursus thibetanus) and Malayan sun bears (Helarctos malayanus)) were taught a simple food rewarded spatial discrimination task. Home cage stereotypy levels ranged between 1 and 45% of all observations (S.E. = 2.75), and high and low stereotypy bears did not differ in the ease with which they learnt the task. However, when responses were no longer rewarded (i.e. food rewards were withheld), as predicted, the most stereotypic animals took the longest to extinguish responding. Contrary to some previous studies, however, further evidence of striatal involvement was limited: behavioural switching rates were not related to stereotypy frequency or to perseveration, and levels of normal activity were only weakly related to perseveration (a trend), leaving the mechanism underlying the relationship between stereotypy and perseveration in these animals unclear. Alternative non-striatal explanations include natural individual variation in habit-formation, general behavioural persistence or compulsiveness and these possibilities require further investigation. © 2005 Elsevier B.V. All rights reserved.
C1 Univ Oxford, Dept Zool, Anim Behav Res Grp, Oxford OX1 3PS, England.
RP Vickery, SS (reprint author), Dept Environm Food & Rural Affairs, Anim Welf Vet Div, 1A Page St, London SW1P 4PQ, England.
EM sophie.vickery@defra.gsi.gov.uk
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NR 47
TC 34
Z9 36
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0168-1591
J9 APPL ANIM BEHAV SCI
JI Appl. Anim. Behav. Sci.
PD JUN
PY 2005
VL 91
IS 3-4
BP 247
EP 260
DI 10.1016/j.applanim.2005.01.005
PG 14
WC Agriculture, Dairy & Animal Science; Behavioral Sciences; Veterinary
Sciences
SC Agriculture; Behavioral Sciences; Veterinary Sciences
GA 932NJ
UT WOS:000229560100006
ER
PT J
AU Adrien, JL
Gattegno, MP
Streri, A
Reynaud, L
Barthelemy, C
AF Adrien, JL
Gattegno, MP
Streri, A
Reynaud, L
Barthelemy, C
TI Early development and creativity in autistic children
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LA French
DT Article; Proceedings Paper
CT National Congress of the Societe-Francaise-de-Pediatrie/Congress of the
Association-des-Pediatres-de-Langue-Francaise
CY JUN 01-04, 2005
CL Paris, FRANCE
SP Soc Francaise Pediat, Assoc Pediat Langue Francaise
DE home movies; interaction; motricity; autism
C1 Univ Paris 05, Inst Psychol, Lab Psychol Clin & Psychopathol, Paris, France.
RP Adrien, JL (reprint author), Univ Paris 05, Inst Psychol, Lab Psychol Clin & Psychopathol, Paris, France.
RI rahmati, narges/C-3932-2011
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Teitelbaum P, 1998, P NATL ACAD SCI USA, V95, P13982, DOI 10.1073/pnas.95.23.13982
NR 9
TC 1
Z9 1
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI PARIS
PA 23 RUE LINOIS, 75724 PARIS, FRANCE
SN 0929-693X
J9 ARCH PEDIATRIE
JI Arch. Pediatr.
PD JUN
PY 2005
VL 12
IS 6
BP 858
EP 860
DI 10.1016/j.arcped.2005.04.023
PG 3
WC Pediatrics
SC Pediatrics
GA 931KC
UT WOS:000229483200075
PM 15904829
ER
PT J
AU Duban, P
AF Duban, P
TI Turbulence!
SO ARCHIVES DE PEDIATRIE
LA French
DT Article; Proceedings Paper
CT National Congress of the Societe-Francaise-de-Pediatrie/Congress of the
Association-des-Pediatres-de-Langue-Francaise
CY JUN 01-04, 2005
CL Paris, FRANCE
SP Soc Francaise Pediat, Assoc Pediat Langue Francaise
DE autism; integration; social bond
C1 Turbulences, F-75015 Paris, France.
RP Duban, P (reprint author), Turbulences, 25 Villa Santos Dumont, F-75015 Paris, France.
NR 0
TC 0
Z9 0
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI PARIS
PA 23 RUE LINOIS, 75724 PARIS, FRANCE
SN 0929-693X
J9 ARCH PEDIATRIE
JI Arch. Pediatr.
PD JUN
PY 2005
VL 12
IS 6
BP 866
EP 868
DI 10.1016/j.arcped.2005.03.026
PG 3
WC Pediatrics
SC Pediatrics
GA 931KC
UT WOS:000229483200078
PM 15904832
ER
PT J
AU Geurts, HM
Verte, S
Oosterlaan, J
Roeyers, H
Sergeant, JA
AF Geurts, HM
Verte, S
Oosterlaan, J
Roeyers, H
Sergeant, JA
TI ADHD subtypes: do they differ in their executive functioning profile?
SO ARCHIVES OF CLINICAL NEUROPSYCHOLOGY
LA English
DT Article
DE ADHD; subtypes; neuropsychology; executive functions; developmental
disorders
ID DEFICIT HYPERACTIVITY DISORDER; ATTENTION-DEFICIT/HYPERACTIVITY
DISORDER; PREDOMINANTLY INATTENTIVE TYPE; DIAGNOSTIC INTERVIEW SCHEDULE;
SLUGGISH COGNITIVE TEMPO; DSM-IV SUBTYPES; UNRELATED DISORDERS;
FRONTAL-LOBE; CHILDREN; AUTISM
AB The present study was designed to investigate the hypothesis that children with Attention Deficit Hyperactivity Disorder combined subtype (ADHD-C) have a generalized executive functioning (EF) [Barkley, R. A. (1997). Behavioural inhibition, sustained attention, and executive functions: Constructing a unifying theory of AD/HD. Psychological Bulletin, 121, 65-94; Barkley, R. A. (1997). ADHD and the nature of self-control. New York: The Guilford Press]. We tested whether ADHD-C and ADHD inattentive subtype (ADHD-I) can be differentiated from each other on EF measures. We compared 16 normally developing boys with 16 boys with ADHD-C and 16 with ADHD-I on five EF domains. The boys were all matched on age, IQ, and the presence of oppositional defiant disorder (ODD)/conduct disorder (CD). Despite carefully diagnosed groups and methodological controls, the results do not support the EF-hypothesis of ADHD-C. Children with ADHD-C differed from normal controls (NC) on tasks related to inhibition; they did not exhibit EF deficits on all EF tasks. Children with ADHD-C also exhibited deficits on non-EF tasks. Furthermore, the ADHD-C and ADHD-I subtypes did not differ from one another. Neuropsychological findings on the domains under study did not yield evidence for the distinctiveness of ADHD-C and ADHD-I subtypes. (c) 2004 National Academy of Neuropsychology. Published by Elsevier Ltd. All rights reserved.
C1 Vrije Univ Amsterdam, Dept Clin Neurophysiol, Amsterdam, Netherlands.
Univ Amsterdam, Div Psychon, NL-1018 WB Amsterdam, Netherlands.
State Univ Ghent, Dept Psychol, B-9000 Ghent, Belgium.
RP Geurts, HM (reprint author), Vrije Univ Amsterdam, Dept Clin Neurophysiol, Amsterdam, Netherlands.
EM h.m.geurts@uva.nl
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PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0887-6177
J9 ARCH CLIN NEUROPSYCH
JI Arch. Clin. Neuropsychol.
PD JUN
PY 2005
VL 20
IS 4
BP 457
EP 477
DI 10.1016/j.acn.2004.11.001
PG 21
WC Psychology, Clinical; Psychology
SC Psychology
GA 934DK
UT WOS:000229686900005
PM 15896560
ER
PT J
AU Sonnenmeier, RM
McSheehan, M
Jorgensen, CM
AF Sonnenmeier, RM
McSheehan, M
Jorgensen, CM
TI A case study of team supports for a student with autism's communication
and engagement within the general education curriculum: Preliminary
report of the beyond access model
SO AUGMENTATIVE AND ALTERNATIVE COMMUNICATION
LA English
DT Article; Proceedings Paper
CT Annual Conference of the TASH/American-Association-on-Mental-Retardation
CY 2003
CL Chicago, IL
SP TASH, Amer Assoc Ment Retardat
DE augmentative and alternative communication (AAC); autism; collaborative
teaming; general education curriculum; inclusive education
ID DISABILITIES
AB The Beyond Access model, a student and team supports planning model, was implemented with a single student who had been integrated into a general education classroom. Preliminary findings are presented through a case study of the 10-year-old student with autism, who, previous to the study, was reported to have an academic level of 18 months to 24 months. A 4-phase process for designing and evaluating supports led to improved collaborative teaming among team members, clarification of priority learning goals for the student, increased engagement and opportunities for learning by the student in the general education curriculum, and improved augmentative and alternative communication outcomes. Potential limitations and costs of the model include staff-time commitment and the involvement of a mentor to guide the process.
C1 Univ New Hampshire, Inst Disabil, UCED, Durham, NH 03824 USA.
RP Sonnenmeier, RM (reprint author), Univ New Hampshire, Inst Disabil, UCED, 10 W Edge Dr, Durham, NH 03824 USA.
EM raes@unh.edu
CR Beukelman D. R., 1998, AUGMENTATIVE ALTERNA
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JORGENSEN C, 2002, UNPUB MENTOR SKILLS
JORGENSEN C, 2002, UNPUB BEST PRACTICES
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NR 59
TC 16
Z9 16
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 0743-4618
J9 AUGMENT ALTERN COMM
JI Augment. Altern. Commun.
PD JUN
PY 2005
VL 21
IS 2
BP 101
EP 115
DI 10.1080/07434610500103608
PG 15
WC Audiology & Speech-Language Pathology; Rehabilitation
SC Audiology & Speech-Language Pathology; Rehabilitation
GA 015DF
UT WOS:000235531400003
ER
PT J
AU Behrendt, RP
AF Behrendt, RP
TI Affiliative drive: Could this be disturbed in childhood autism?
SO BEHAVIORAL AND BRAIN SCIENCES
LA English
DT Editorial Material
ID SPECTRUM DISORDER; INFANTILE-AUTISM; EYE-MOVEMENTS; CHILDREN; BRAIN;
ATTENTION; PSYCHOPATHOLOGY; OXYTOCIN; MIND; MRI
AB Affect mirroring allows infants to distinguish emotional and intentional states of significant others, which - in the pursuit of their own drive satisfaction, including satisfaction of the affiliative drive - become important contextual stimuli predictive of reward. Learning to perceive and manipulate others' attitudes toward oneself in pursuit of affiliative reward may be an important step in social development that is impaired in autism.
C1 Walton Hosp, Dept Psychol Med Elderly, Chesterfield S40 3TH, England.
RP Behrendt, RP (reprint author), Walton Hosp, Dept Psychol Med Elderly, Chesterfield S40 3TH, England.
EM rp.behrendt@btinternet.com
CR Adolphs R, 2000, J NEUROSCI, V20, P2683
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NR 28
TC 0
Z9 0
PU CAMBRIDGE UNIV PRESS
PI NEW YORK
PA 40 WEST 20TH ST, NEW YORK, NY 10011-4211 USA
SN 0140-525X
J9 BEHAV BRAIN SCI
JI Behav. Brain Sci.
PD JUN
PY 2005
VL 28
IS 3
BP 350
EP +
PG 20
WC Psychology, Biological; Behavioral Sciences; Neurosciences
SC Psychology; Behavioral Sciences; Neurosciences & Neurology
GA 965SI
UT WOS:000231970200002
ER
PT J
AU Troisi, A
D'Amato, FR
AF Troisi, A
D'Amato, FR
TI Deficits in affillative reward: An endophenotype for psychiatric
disorders?
SO BEHAVIORAL AND BRAIN SCIENCES
LA English
DT Editorial Material
ID ATTACHMENT; PSYCHOPATHY; PERSONALITY; BEHAVIOR; GENE
AB Depue & Morrone-Strupinsky's (D&M-Ss) model of affiliation meets the criteria advanced for the definition of behavior systems and endophenotypes. We argue that its application in psychiatry could be useful for identifying a biological pathophysiology common to a variety of conditions that are currently classified in very different categories of psychiatric nosography, including autism, schizoid personality, primary psychopathy, and dismissing attachment.
C1 Univ Roma Tor Vergata, Dept Neurosci, I-00161 Rome, Italy.
CNR, Inst Neurosci, Sect Psychobiol & Psychopharmacol, I-00137 Rome, Italy.
RP Troisi, A (reprint author), Univ Roma Tor Vergata, Dept Neurosci, I-00161 Rome, Italy.
EM alfonso.troisi@uniroma2.it; f.damato@ipsifar.rm.cnr.it
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NR 15
TC 2
Z9 2
PU CAMBRIDGE UNIV PRESS
PI NEW YORK
PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA
SN 0140-525X
J9 BEHAV BRAIN SCI
JI Behav. Brain Sci.
PD JUN
PY 2005
VL 28
IS 3
BP 365
EP +
PG 20
WC Psychology, Biological; Behavioral Sciences; Neurosciences
SC Psychology; Behavioral Sciences; Neurosciences & Neurology
GA 965SI
UT WOS:000231970200017
ER
PT J
AU Olajossy, M
Olajossy-Hilkesberger, L
Tkaczuk-Wlach, J
AF Olajossy, M
Olajossy-Hilkesberger, L
Tkaczuk-Wlach, J
TI Bipolar affective disorder in a male with a deletion of Y chromosome - a
case report
SO BIPOLAR DISORDERS
LA English
DT Article
DE bipolar disorder; chromosomal abnormality; chromosome Y; deletion
ID SCHIZOPHRENIA; AUTISM; GENES
AB We report on a 25-year-old male with bipolar disorder, dysmorphic features and a deletion of the long arm of Y chromosome. A potential association between sex chromosome abnormalities and a susceptibility to major psychiatric disorders has been documented. However there have been very few reports on the coincidence of Y chromosome aberrations with bipolar disorder. Cytogenetic studies have contributed to the identification of several disease genes. Karyotyping of patients with bipolar disorder in order to identify candidate regions for linkage studies has been recommended.
C1 Univ Med Sch, Dept Psychiat, PL-20439 Lublin, Poland.
Univ Med Sch, Dept Reprod & Androl, PL-20439 Lublin, Poland.
RP Olajossy-Hilkesberger, L (reprint author), Univ Med Sch, Dept Psychiat, Gluska 1, PL-20439 Lublin, Poland.
EM l.hilkesberger@wp.pl
CR Badner JA, 2002, MOL PSYCHIATR, V7, P405, DOI 10.1038/sj/mp/4001012
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Rajagopalan M, 1998, AM J MED GENET, V81, P64, DOI 10.1002/(SICI)1096-8628(19980207)81:1<64::AID-AJMG12>3.0.CO;2-U
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NR 16
TC 2
Z9 2
PU BLACKWELL MUNKSGAARD
PI FREDERIKSBERG C
PA 1 ROSENORNS ALLE, DK-1970 FREDERIKSBERG C, DENMARK
SN 1398-5647
J9 BIPOLAR DISORD
JI Bipolar Disord.
PD JUN
PY 2005
VL 7
IS 3
BP 298
EP 301
DI 10.1111/j.1399-5618.2005.00198.x
PG 4
WC Clinical Neurology; Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA 925VJ
UT WOS:000229081100011
PM 15898969
ER
PT J
AU Russell, AJ
Mataix-Cols, D
Anson, M
Murphy, DGM
AF Russell, AJ
Mataix-Cols, D
Anson, M
Murphy, DGM
TI Obsessions and compulsions in Asperger syndrome and high-functioning
autism
SO BRITISH JOURNAL OF PSYCHIATRY
LA English
DT Article
ID PERVASIVE DEVELOPMENTAL DISORDERS; DIAGNOSTIC INTERVIEW; REPETITIVE
THOUGHTS; BEHAVIOR
AB Background Obsessive-compulsive behaviours are common and disabling in autistic-spectrum disorders (ASD) but little is known about how they compare with those experienced by people with obsessive-compulsive disorder (OCD).
Aim To make such a comparison
Method A group of adults with high-functioning ASD (n=40) were administered theYale-Brown Obsessive-Compulsive Scale and Symptom Checklist and their symptoms compared with a gender-matched group of adults with a primary diagnosis of OCD (n=45). OCD symptoms were carefully distinguished from stereotypic behaviours and interests usually displayed by those with ASD.
Results The two groups had similar frequencies of obsessive-compulsive symptoms, with only somatic obsessions and repeating rituals being more common in the OCD group. The OCD group had higher obsessive-compulsive symptom severity ratings but up to 50% of the ASD group reported at least moderate levels of interference from their symptoms.
Conclusions Obsessions and compulsions are both common in adults with high-functioning ASD and are associated with significant levels of distress.
C1 Kings Coll London, Dept Psychol, Inst Psychiat, London SE5 8AF, England.
Kings Coll London, Dept Psychol Med, Inst Psychiat, London SE5 8AF, England.
RP Russell, AJ (reprint author), Kings Coll London, Dept Psychol, Inst Psychiat, De Crespigny Pk, Denmark Hill,POB 77, London SE5 8AF, England.
EM a.russell@iop.kcl.ac.uk
RI Russell, Ailsa/F-2484-2010; Mataix-Cols, David/G-3843-2010; Russell,
Ailsa/J-8268-2013
OI Russell, Ailsa/0000-0002-8443-9381
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World Health Organisation, 1992, ICD 10 CLASS MENT BE
NR 14
TC 77
Z9 79
PU ROYAL COLLEGE OF PSYCHIATRISTS
PI LONDON
PA BRITISH JOURNAL OF PSYCHIATRY 17 BELGRAVE SQUARE, LONDON SW1X 8PG,
ENGLAND
SN 0007-1250
J9 BRIT J PSYCHIAT
JI Br. J. Psychiatry
PD JUN
PY 2005
VL 186
BP 525
EP 528
DI 10.1192/bjp.186.6.525
PG 4
WC Psychiatry
SC Psychiatry
GA 934FN
UT WOS:000229692400014
PM 15928364
ER
PT J
AU Iyer, A
AF Iyer, A
TI Autism: Mind and brain
SO BRITISH JOURNAL OF PSYCHIATRY
LA English
DT Book Review
C1 Elms Hlth Ctr, Halesowen B63 2UR, W Midlands, England.
RP Iyer, A (reprint author), Elms Hlth Ctr, Slade Rd, Halesowen B63 2UR, W Midlands, England.
CR Frith U., 2004, AUTISM MIND BRAIN
NR 1
TC 0
Z9 0
PU ROYAL COLLEGE OF PSYCHIATRISTS
PI LONDON
PA BRITISH JOURNAL OF PSYCHIATRY 17 BELGRAVE SQUARE, LONDON SW1X 8PG,
ENGLAND
SN 0007-1250
J9 BRIT J PSYCHIAT
JI Br. J. Psychiatry
PD JUN
PY 2005
VL 186
BP 545
EP 546
DI 10.1192/bjp.186.6.545-a
PG 2
WC Psychiatry
SC Psychiatry
GA 934FN
UT WOS:000229692400029
ER
PT J
AU Maestro, S
Muratori, F
Cavallaro, MC
Pecini, C
Cesari, A
Paziente, A
Stern, D
Golse, B
Palacio-Espasa, F
AF Maestro, S
Muratori, F
Cavallaro, MC
Pecini, C
Cesari, A
Paziente, A
Stern, D
Golse, B
Palacio-Espasa, F
TI How young children treat objects and people: An empirical study of the
first year of life in autism
SO CHILD PSYCHIATRY & HUMAN DEVELOPMENT
LA English
DT Article
DE autism; joint attention; home videos
ID JOINT ATTENTION; HOME MOVIES; SPECTRUM DISORDER; EARLY RECOGNITION; FACE
RECOGNITION; AGE; INDIVIDUALS; INFANCY
AB Objective. To figure out features of autism before the age of one and to explore the pathways of early social and nonsocial attention in autism through home movies. Method. Home movies of 15 children later diagnosed with autism, are compared with home movies of 13 typical children. The films of the two groups have been mixed and rated by blind observers through a Grid composed of social and nonsocial item and applied to two age ranges: 0-6months (T1) and 7-12months (T2). Two MANOVAs, an ANOVA and discriminant analyses were applied. Results. Significant differences between the two groups were found only for the item in the Social area at T1 but not at T2, when groups did not differ in either social or nonsocial areas. At T2 children with autism had significantly higher scores in the nonsocial area while normal children did not show significant differences between areas. Discriminant analyses revealed that social attention can distinguish the two groups at T1 but not at T2. Conclusions. The fundamental impairment of joint attention in autism could be considered a consequence of the early atypical developmental gap and of a later disconnection between attention to people and objects. Abnormal developmental trajectories for social and nonsocial. attention could help us in the future to understand relationships between adaptive capacities and symptoms, and set the stage for appropriate early screening instruments.
C1 Univ Pisa, Pisa, Italy.
RP Muratori, F (reprint author), IRCCS Stella Maris, Via Giacinti 2, I-56018 Pisa, Italy.
EM f.muratori@inpe.unipi.it
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NR 29
TC 42
Z9 44
PU KLUWER ACADEMIC-HUMAN SCIENCES PRESS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013-1578 USA
SN 0009-398X
J9 CHILD PSYCHIAT HUM D
JI Child Psychiat. Hum. Dev.
PD SUM
PY 2005
VL 35
IS 4
BP 383
EP 396
DI 10.1007/s10578-005-2695-x
PG 14
WC Psychology, Developmental; Pediatrics; Psychiatry
SC Psychology; Pediatrics; Psychiatry
GA 931NQ
UT WOS:000229492400006
PM 15886871
ER
PT J
AU Kerwin, ME
Eicher, PS
Gelsinger, J
AF Kerwin, ME
Eicher, PS
Gelsinger, J
TI Parental report of eating problems and gastrointestinal symptoms in
children with pervasive developmental disorders
SO CHILDRENS HEALTH CARE
LA English
DT Article; Proceedings Paper
CT 28th Annual Meeting of the Association-for-Behavior-Analysis
CY MAY, 2002
CL TORONTO, CANADA
SP Assoc Behav Anal
ID GASTROESOPHAGEAL-REFLUX DISEASE; SELF-INJURIOUS-BEHAVIOR; FEEDING
PROBLEMS; AUTISM; PICA; CHILDHOOD; INFANTS; POPULATION; PREVALENCE
AB Parents of children of 89 children with pervasive developmental disorder were surveyed about their child's eating, gastrointestinal symptoms, and behavior problems. Results revealed potentially interesting relationships among self-injurious behavior, pica, feeding problems, and gastrointestinal symptoms in this population. Although over 60% of children were reported to have strong food preferences, only 6.7% of parents reported that their child had a feeding problem. Most children exhibited high rates of pica and self-injurious behavior that affected the family's quality of life. Some children experienced at least one symptom of gastrointestinal distress weekly, and bowel problems appeared to be related to some aspects of feeding. Although methodological issues limit these data, future research should focus on further relations among these factors in this population.
C1 Rowan Univ, Dept Psychol, Glassboro, NJ 08028 USA.
RP Kerwin, ME (reprint author), Rowan Univ, Dept Psychol, 201 Mullica Hill Rs, Glassboro, NJ 08028 USA.
EM kerwin@rowan.edu
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NR 34
TC 11
Z9 11
PU LAWRENCE ERLBAUM ASSOC INC
PI MAHWAH
PA 10 INDUSTRIAL AVE, MAHWAH, NJ 07430-2262 USA
SN 0273-9615
J9 CHILD HEALTH CARE
JI Child. Health Care
PD SUM
PY 2005
VL 34
IS 3
BP 217
EP 234
DI 10.1207/s15326888chc3403_4
PG 18
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 962PN
UT WOS:000231744800004
ER
PT J
AU Wymbs, BT
Robb, AA
Chronis, AM
Massetti, GM
Fabiano, GA
Arnold, FW
Brice, AC
Gnagy, EM
Pelham, WE
Burrows-MacLean, L
Hoffman, MT
AF Wymbs, BT
Robb, AA
Chronis, AM
Massetti, GM
Fabiano, GA
Arnold, FW
Brice, AC
Gnagy, EM
Pelham, WE
Burrows-MacLean, L
Hoffman, MT
TI Long-term, multimodal treatment of a child with Asperger's syndrome and
comorbid disruptive behavior problems: A case illustration
SO COGNITIVE AND BEHAVIORAL PRACTICE
LA English
DT Article
ID ATTENTION-DEFICIT/HYPERACTIVITY-DISORDER; PERVASIVE DEVELOPMENTAL
DISORDERS; DEFICIT HYPERACTIVITY DISORDER; SUMMER TREATMENT PROGRAM;
YOUNG-CHILDREN; PHARMACOLOGICAL-TREATMENT; ADHD CHILDREN; AUTISM;
METHYLPHENIDATE; SYMPTOMS
AB Despite Asperger's Syndrome (AS) becoming a widely recognized disorder on the pervasive developmental spectrum, surprisingly few studies have assessed the utility of psychosocial and/or pharmacological treatments for children with AS. Further, studies have not examined the effects of treatment on disruptive behavior problems commonly exhibited by children with AS. This case study demonstrates the Positive effects of an intensive, long-term, multimodal treatment targeting the symptoms and functional impairment of a school-age male with AS and comorbid disruptive behavior problems. Components of the comprehensive treatment included a behavioral summer treatment program, behavioral parent and teacher training, and medication. Results highlight the potential efficacy of treating the chronic functional impairments of AS and associated behavior problem with an intensive, long-term, multimodal treatment.
C1 SUNY Buffalo, Ctr Children & Families, Buffalo, NY 14214 USA.
Univ Maryland, College Pk, MD 20742 USA.
RP Wymbs, BT (reprint author), SUNY Buffalo, Ctr Children & Families, 318 Diefendorf Hall, Buffalo, NY 14214 USA.
EM bwymbs@acsu.buffalo.edu
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NR 68
TC 2
Z9 2
PU ASSOC ADV BEHAVIOR THERAPY
PI NEW YORK
PA 305 7TH AVE #16A, NEW YORK, NY 10001-6008 USA
SN 1077-7229
J9 COGN BEHAV PRACT
JI Cogn. Behav. Pract.
PD SUM
PY 2005
VL 12
IS 3
BP 338
EP 350
DI 10.1016/S1077-7229(05)80056-2
PG 13
WC Psychology, Clinical
SC Psychology
GA 989OH
UT WOS:000233682900008
ER
PT J
AU Grice, SJ
Halit, H
Farroni, T
Baron-Cohen, S
Bolton, P
Johnson, MH
AF Grice, SJ
Halit, H
Farroni, T
Baron-Cohen, S
Bolton, P
Johnson, MH
TI Neural correlates of eye-gaze detection in young children with autism
SO CORTEX
LA English
DT Article
DE autism; autistic spectrum disorder; face perception; ERP; HD-ERP;
developmental disorder; eye-gaze
ID GEODESIC SENSOR NET; FUSIFORM FACE AREA; ASPERGER-SYNDROME; REVISED
VERSION; RECOGNITION; INFANTS; PERCEPTION; SPECIALIZATION; POTENTIALS;
INDIVIDUALS
AB Various reports have demonstrated difficulties in eye-gaze processing in older children and adults with autism. However, little is known about the neural or developmental origin of such difficulties. In the present study, we used high-density Event-Related Potentials (HD-ERPs) to record the neural correlates of gaze processing in young children with autism, and their age-matched controls. In addition, to determine normal gaze processing development we also tested a non-autism adult group. The data obtained from the children with autism resembled that previously observed in typical 4-month old infants. In contrast, the control group showed the same pattern as typical adults. These findings suggest that the neural correlates of gaze direction processing may be delayed in young children with autism.
C1 Univ London, Birkbeck Coll, Sch Psychol, Ctr Brain & Cognit Dev, London WC1E 7JL, England.
Univ Cambridge, Autism Res Ctr, Dept Expt Psychol & Psychiat, Cambridge CB2 1TN, England.
Kings Coll London, Inst Psychiat, Social Genet & Dev Psychiat Res Ctr, London WC2R 2LS, England.
Univ Padua, Dipartimento Psicol Sviluppo & Socializzaz, I-35100 Padua, Italy.
RP Grice, SJ (reprint author), Univ London, Birkbeck Coll, Sch Psychol, Ctr Brain & Cognit Dev, 32 Torrington Sq, London WC1E 7JL, England.
EM mark.johnson@psychology.bbk.ac.uk
RI Bolton, Patrick/E-8501-2010
OI Bolton, Patrick/0000-0002-5270-6262
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NR 47
TC 69
Z9 70
PU MASSON DIVISIONE PERIODICI
PI MILAN
PA VIA FRATELLI BRESSAN 2, 20126 MILAN, ITALY
SN 0010-9452
J9 CORTEX
JI Cortex
PD JUN
PY 2005
VL 41
IS 3
BP 342
EP 353
DI 10.1016/S0010-9452(08)70271-5
PG 12
WC Behavioral Sciences; Neurosciences
SC Behavioral Sciences; Neurosciences & Neurology
GA 923WV
UT WOS:000228941100007
PM 15871599
ER
PT J
AU Brown, C
Gruber, T
Boucher, J
Rippon, G
Brock, J
AF Brown, C
Gruber, T
Boucher, J
Rippon, G
Brock, J
TI Gamma abnormalities during perception of illusory figures in autism
SO CORTEX
LA English
DT Article
DE EEG; 40 Hz; gamma EEG; binding; autism; development; attention;
perception
ID EVENT-RELATED POTENTIALS; HUMAN EEG; BAND RESPONSES; BRAIN ACTIVITY;
OBJECT REPRESENTATION; SELECTIVE ATTENTION; VISUAL RESPONSES; TASK;
STIMULUS; HUMANS
AB This experiment was designed to test the hypothesis that perceptual abnormalities in autism might be associated with alteration of induced gamma activity patterns overlying visual cortical regions. EEG was recorded from six adolescents with autism and eight controls matched on chronological age, and verbal and nonverbal mental age, whilst identifying the presence or absence of an illusory Kanizsa shape. Although there were no reaction time or accuracy differences between the groups there were significant task-related differences in cortical activity. Control participants showed typical gamma-band activity over parietal regions at around 350 msec post onset of shape trials, similar to gamma patterns found in previous studies with non-impaired adults. In contrast, autistic participants showed overall increased activity, including an early 100 msec gamma peak and a late induced peak, 50 to 70 msec earlier than that shown by the control group. We interpret the abnormal gamma activity to reflect decreased "signal to noise" due to decreased inhibitory processing. In this experiment we did not establish a link between altered perception and abnormal gamma, as the autistic participants' behaviour did not differ from the controls. Future work should be designed to replicate this phenomenon and establish the perceptual consequences of altered gamma activity.
C1 Univ W England, Sch Psychol, Bristol BS8 1TN, Avon, England.
Univ Leipzig, Inst Allgemeine Psychol, D-7010 Leipzig, Germany.
Univ Warwick, Dept Psychol, Coventry CV4 7AL, W Midlands, England.
Aston Univ, Sch Life & Hlth Sci, Neurosci Res Inst, Birmingham B4 7ET, W Midlands, England.
Univ Warwick, Dept Psychol, Coventry CV4 7AL, W Midlands, England.
RP Brown, C (reprint author), Univ W England, Sch Psychol, 8 Woodland Rd, Bristol BS8 1TN, Avon, England.
EM carolinec.brown@uwc.ac.uk
CR American Psychiatric Association, 1994, DIGN STAT MAN MENT D
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NR 73
TC 62
Z9 62
PU MASSON DIVISIONE PERIODICI
PI MILAN
PA VIA FRATELLI BRESSAN 2, 20126 MILAN, ITALY
SN 0010-9452
J9 CORTEX
JI Cortex
PD JUN
PY 2005
VL 41
IS 3
BP 364
EP 376
DI 10.1016/S0010-9452(08)70273-9
PG 13
WC Behavioral Sciences; Neurosciences
SC Behavioral Sciences; Neurosciences & Neurology
GA 923WV
UT WOS:000228941100009
PM 15871601
ER
PT J
AU Waltz, M
AF Waltz, M
TI Gender, sexuality and autism: Challenging assumptions, theorizing
alternatives
SO CULTURE HEALTH & SEXUALITY
LA English
DT Meeting Abstract
C1 Univ Sunderland, Sch Arts Design Media & Culture, Sunderland SR2 7EE, Durham, England.
NR 0
TC 0
Z9 0
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND
SN 1369-1058
J9 CULT HEALTH SEX
JI Cult. Health Sex
PD JUN
PY 2005
VL 7
SU 1
BP S85
EP S86
PG 2
WC Family Studies; Social Sciences, Biomedical
SC Family Studies; Biomedical Social Sciences
GA 950YZ
UT WOS:000230896600151
ER
PT J
AU Robinson, S
Hoheisel, B
Windischberger, C
Habel, U
Lanzenberger, R
Moser, E
AF Robinson, S
Hoheisel, B
Windischberger, C
Habel, U
Lanzenberger, R
Moser, E
TI fMRI of the emotions: Towards an improved understanding of amygdala
function
SO CURRENT MEDICAL IMAGING REVIEWS
LA English
DT Review
DE fMRI; amygdala; methods; artefacts; applications; psychiatry
ID POSTTRAUMATIC-STRESS-DISORDER; EVENT-RELATED FMRI; DIFFERENTIAL NEURAL
RESPONSE; NEGATIVE FACIAL EXPRESSIONS; HUMAN BRAIN ACTIVATION; CEREBRAL
BLOOD-FLOW; SEX-DIFFERENCES; IMPAIRED RECOGNITION; GENDER-DIFFERENCES;
MAJOR DEPRESSION
AB The last eight years have seen a rapid expansion in the number of functional Magnetic Resonance Imaging (fMRI) studies of the emotions, examining the role of the amygdala in healthy human emotion function as well as in psychiatric and neurological disorders such as depression, autism, anxiety disorders and schizophrenia. Amongst widely divergent results, the central findings of these studies are reviewed, as well as the most important unresolved questions. The location of central elements of the limbic system, of which the amygdala is a part, makes it a challenging area to study with fMRI. The problems besetting the region are reviewed: signal loss and image distortion in Echo Planar Imaging and artefacts arising from physiological fluctuations, head motion and draining veins. We describe general approaches to mitigating these problems and which of those we find to be most useful. An illustrative example from our lab is presented to indicate the typical progression of an emotion fMRI session and to allow discussion of the strategies employed which enable robust amygdala function to be charted in single subjects and groups. We conclude by examining the prospects for technical improvement and clinical applications.
C1 Med Univ Vienna, Dept Med Phys, Ctr Biomed Engn & Phys, NMR Grp, A-1090 Vienna, Austria.
Med Univ Vienna, MR Ctr Excellence, A-1090 Vienna, Austria.
Univ Vienna, Dept Clin & Hlth Psychol, Inst Psychol, Vienna, Austria.
Univ Aachen, Dept Psychiat & Psychotherapy, D-5100 Aachen, Germany.
Med Univ Vienna, Dept Gen Psychiat, A-1090 Vienna, Austria.
Med Univ Vienna, Dept Radiodiagnost, A-1090 Vienna, Austria.
Univ Penn, Dept Psychiat, Philadelphia, PA 19104 USA.
RP Moser, E (reprint author), Med Univ Vienna, Dept Med Phys, Ctr Biomed Engn & Phys, NMR Grp, Wahringerstr 13, A-1090 Vienna, Austria.
EM ewald.moser@meduniwien.ac.at
RI Moser, Ewald/B-3666-2013
OI Moser, Ewald/0000-0001-8278-9583
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NR 189
TC 10
Z9 10
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y26, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
EMIRATES
SN 1573-4056
J9 CURR MED IMAGING REV
JI Curr. Med. Imaging Rev.
PD JUN
PY 2005
VL 1
IS 2
BP 115
EP 129
DI 10.2174/1573405054038717
PG 15
WC Radiology, Nuclear Medicine & Medical Imaging
SC Radiology, Nuclear Medicine & Medical Imaging
GA 988YF
UT WOS:000233639400002
ER
PT J
AU Standen, PJ
Brown, DJ
AF Standen, PJ
Brown, DJ
TI Virtual reality in the rehabilitation of people with intellectual
disabilities: Review
SO CYBERPSYCHOLOGY & BEHAVIOR
LA English
DT Review
ID LEARNING-DISABILITIES; TRAINING PEOPLE; BRAIN-INJURY; ENVIRONMENTS;
CHILDREN; AUTISM; EDUCATION
AB Virtual reality (VR) possesses many qualities that give it rehabilitative potential for people with intellectual disabilities, both as an intervention and an assessment. It can provide a safe setting in which to practice skills that might carry too many risks in the real world. Unlike human tutors, computers are infinitely patient and consistent. Virtual worlds can be manipulated in ways the real world cannot be and can convey concepts without the use of language or other symbol systems. Published applications for this client group have all been as rehabilitative interventions. These are described in three groups: promoting skills for independent living, enhancing cognitive performance, and improving social skills. Five groups of studies are reviewed that utilize virtual technology to promote skills for independent living: grocery shopping, preparing food, orientation, road safety, and manufacturing skills. Fears that skills or habits learnt in a virtual setting would not transfer to the real world setting have not been supported by the available evidence, apart from those studies with people with autistic spectrum disorders. Future directions are in the development of more applications for independent living skills, exploring interventions for promoting motor and cognitive skills, and the developments of ecologically valid forms of assessment.
C1 Univ Nottingham, Div Rehabil & Ageing, Sch Community Hlth Sci, Nottingham NG7 2RD, England.
Nottingham Trent Univ, Sch Comp & Math, Nottingham, England.
RP Standen, PJ (reprint author), Queens Med Ctr, Div Rehabil & Ageing, Sch Med, B Floor,Clifton Blvd, Nottingham NG7 2UH, England.
EM p.standen@nottingham.ac.uk
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NR 56
TC 29
Z9 36
PU MARY ANN LIEBERT INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1094-9313
J9 CYBERPSYCHOL BEHAV
JI CyberPsychol. Behav.
PD JUN
PY 2005
VL 8
IS 3
BP 272
EP 282
DI 10.1089/cpb.2005.8.272
PG 11
WC Communication; Psychology, Applied
SC Communication; Psychology
GA 937YA
UT WOS:000229961400022
PM 15971976
ER
PT J
AU Courchesne, E
Redcay, E
Morgan, JT
Kennedy, DP
AF Courchesne, E
Redcay, E
Morgan, JT
Kennedy, DP
TI Autism at the beginning: Microstructural and growth abnormalities
underlying the cognitive and behavioral phenotype of autism
SO DEVELOPMENT AND PSYCHOPATHOLOGY
LA English
DT Review
ID FUNCTIONAL MAGNETIC-RESONANCE; DEVELOPMENTAL CEREBELLAR ABNORMALITY;
MATTER VOLUME INCREASE; FRONTAL-CORTEX; SELECTIVE ATTENTION; CORTICAL
ACTIVATION; HEAD CIRCUMFERENCE; SPECTRUM DISORDER; BRAIN OVERGROWTH;
CEREBRAL-CORTEX
AB Autistic symptoms begin in the first years of life, and recent magnetic resonance imaging studies have discovered brain growth abnormalities that precede and overlap with the onset of these symptoms. Recent postmortem studies of the autistic brain provide evidence of cellular abnormalities and processes that may underlie the recently discovered early brain overgrowth and arrest of growth that marks the first years of life in autism. Alternative origins and time tables for these cellular defects and processes are discussed. These cellular and growth abnormalities are most pronounced in frontal, cerebellar, and temporal structures that normally mediate the development of those same higher order social, emotional, speech, language, speech, attention, and cognitive functions that characterize autism. Cellular and growth pathologies are milder and perhaps nonexistent in other structures (e.g., occipital cortex), which are known to mediate functions that are often either mildly affected or entirely unaffected in autistic patients. It is argued that in autism, higher order functions largely fail to develop normally in the first place because frontal, cerebellar, and temporal cellular and growth pathologies occur prior to and during the critical period when these higher order neural systems first begin to form their circuitry. It is hypothesized that microstructural maldevelopment results in local and short distance overconnectivity in frontal cortex that is largely ineffective and in a failure of long-distance cortical-cortical coupling, and thus a reduction in frontal-posterior reciprocal connectivity. This altered circuitry impairs the essential role of frontal cortex in integrating information from diverse functional systems (emotional, sensory, autonomic, memory, etc.) and providing context-based and goal-directed feedback to lower level systems.
C1 Univ Calif San Diego, San Diego, CA 92103 USA.
Childrens Hosp, Res Ctr, San Diego, CA USA.
RP Courchesne, E (reprint author), Ctr Autism Res, 8110 La Jolla Shores Dr,Suite 201, La Jolla, CA 92037 USA.
EM ecourchesne@ucsd.edu
RI Redcay, Elizabeth/C-7818-2011
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NR 110
TC 101
Z9 103
PU CAMBRIDGE UNIV PRESS
PI NEW YORK
PA 40 WEST 20TH ST, NEW YORK, NY 10011-4211 USA
SN 0954-5794
J9 DEV PSYCHOPATHOL
JI Dev. Psychopathol.
PD SUM
PY 2005
VL 17
IS 3
BP 577
EP 597
DI 10.1017/S0954579405050285
PG 21
WC Psychology, Developmental
SC Psychology
GA 990VT
UT WOS:000233772000002
PM 16262983
ER
PT J
AU Johnson, MH
Griffin, R
Csibra, G
Halit, H
Farroni, T
De Haan, M
Tucker, LA
Baron-Cohen, S
Richards, J
AF Johnson, MH
Griffin, R
Csibra, G
Halit, H
Farroni, T
De Haan, M
Tucker, LA
Baron-Cohen, S
Richards, J
TI The emergence of the social brain network: Evidence from typical and
atypical development
SO DEVELOPMENT AND PSYCHOPATHOLOGY
LA English
DT Article
ID EVENT-RELATED-POTENTIALS; INDEPENDENT COMPONENT ANALYSIS; FUSIFORM FACE
AREA; COGNITIVE NEUROSCIENCE; ASPERGER-SYNDROME; VISUAL-ATTENTION; GAZE
DIRECTION; YOUNG-CHILDREN; HUMAN INFANTS; VIEWING EYE
AB Several research groups have identified a network of regions of the adult cortex that are activated during social perception and cognition tasks. In this paper we focus on the development of components of this social brain network during early childhood and test aspects of a particular viewpoint on human functional brain development: "interactive specialization." Specifically, we apply new data analysis techniques to a previously published data set of event-related potential (ERP) studies involving 3-, 4-, and 12-month-old infants viewing faces of different orientation and direction of eye gaze. Using source separation and localization methods, several likely generators of scalp recorded ERP are identified, and we describe how they are modulated by stimulus characteristics. We then review the results of a series of experiments concerned with perceiving and acting on eye gaze, before reporting on a new experiment involving young children with autism. Finally, we discuss predictions based on the atypical emergence of the social brain network.
C1 Univ London Birkbeck Coll, Ctr Brain & Cognit Dev, Sch Psychol, London WC1E 7HX, England.
Univ Cambridge, Cambridge CB2 1TN, England.
UCL, London WC1E 6BT, England.
Univ S Carolina, Columbia, SC 29208 USA.
RP Johnson, MH (reprint author), Univ London Birkbeck Coll, Ctr Brain & Cognit Dev, Sch Psychol, Malet St, London WC1E 7HX, England.
EM mark.Johnson@bbk.ac.uk
RI de Haan, Michelle/C-5070-2008; Csibra, Gergely/C-4345-2008
OI Csibra, Gergely/0000-0002-7044-3056
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NR 84
TC 116
Z9 119
PU CAMBRIDGE UNIV PRESS
PI NEW YORK
PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA
SN 0954-5794
J9 DEV PSYCHOPATHOL
JI Dev. Psychopathol.
PD SUM
PY 2005
VL 17
IS 3
BP 599
EP 619
DI 10.1017/S0954579405050297
PG 21
WC Psychology, Developmental
SC Psychology
GA 990VT
UT WOS:000233772000003
PM 16262984
ER
EF