FN Thomson Reuters Web of Science™
VR 1.0
PT J
AU Kelley, E
Naigles, L
Fein, D
AF Kelley, Elizabeth
Naigles, Letitia
Fein, Deborah
TI An in-depth examination of optimal outcome children with a history of
autism spectrum disorders
SO RESEARCH IN AUTISM SPECTRUM DISORDERS
LA English
DT Article
DE High-functioning autism; Outcome; Adaptive behavior; Optimal outcome;
Language
ID PERVASIVE DEVELOPMENTAL DISORDER; INTENSIVE BEHAVIORAL TREATMENT; EARLY
INTERVENTION; COMMUNICATION; IDENTIFICATION; PREDICTORS; CHILDHOOD;
STABILITY; EFFICACY; DEFICITS
AB Previous research has suggested that some children with autism spectrum disorders (ASD) may improve to such an extent that they lose their diagnosis, yet little research has examined these 'optimal outcome' children in depth. We examined multiple aspects of functioning in a group of 13 optimal outcome (OO) children, matched on age, gender, and non-verbal IQ to a group of typically developing children (N = 14) and a group of high-functioning children with ASD who still retained a diagnosis on the autism spectrum (N = 14). These children were tested on average about eight years after they had been diagnosed (OO = 93 months, HFA = 94 months). Unlike their high-functioning peers with ASD, the OO group's adaptive and problem behavior scores fell within the average range. They also showed average language and communication scores on all language measures. The HFA group, however, continued to show pragmatic, linguistic, social, and behavioral difficulties. The OO children tended to have been diagnosed at younger ages and were significantly more likely to have received intensive early intervention. Although the high-functioning children with ASD continued to show difficulties in the behavioral realm, the individuals in the OO group were functioning within the average range on all measures. Future research should address how this optimal outcome is achieved. (c) 2010 Elsevier Ltd. All rights reserved.
C1 [Kelley, Elizabeth; Naigles, Letitia; Fein, Deborah] Univ Connecticut, Dept Psychol, Storrs, CT 06269 USA.
RP Kelley, E (reprint author), Queens Univ, Dept Psychol, 62 Arch St, Kingston, ON K7L 3N6, Canada.
EM kelleyb@queensu.ca
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NR 41
TC 18
Z9 18
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1750-9467
J9 RES AUTISM SPECT DIS
JI Res. Autism Spectr. Disord.
PD JUL-SEP
PY 2010
VL 4
IS 3
BP 526
EP 538
DI 10.1016/j.rasd.2009.12.001
PG 13
WC Education, Special; Psychology, Developmental; Psychiatry;
Rehabilitation
SC Education & Educational Research; Psychology; Psychiatry; Rehabilitation
GA 587AS
UT WOS:000276959200024
ER
PT J
AU Yang, PC
Lung, FW
Jong, YJ
Hsu, HY
Chen, CC
AF Yang, Pinchen
Lung, For-Wey
Jong, Yuh-Jyh
Hsu, Hsiu-Yi
Chen, Cheng-Chung
TI Stability and change of cognitive attributes in children with
uneven/delayed cognitive development from preschool through childhood
SO RESEARCH IN DEVELOPMENTAL DISABILITIES
LA English
DT Article
DE Cognitive stability; Intellectual disability; Autism; Preschool age
child
ID AUTISTIC SPECTRUM; YOUNG-CHILDREN; INTELLIGENCE; DISORDER; SCORES; AGE;
RELIABILITY; PERFORMANCE; PARAMETERS; PROGRAMS
AB As part of an ongoing clinical service program for children with developmental delay in an Asian developing country, we analyzed the cognitive attributes of 362 Taiwanese children (average age 48.5 +/- 12.9 month-old) with uneven/delayed cognitive development as they were assessed repeatedly with average duration of 39.7 +/- 22.6 months from preschool through early childhood. The objectives were to determine the stability and related factors in cognitive scores of these 362 children belonging to three diagnostic subgroups: 181 children with non-autistic mental retardation (MR), 95 children with autism spectrum disorder (ASD) and 64 children with mixed type developmental language disorder (DLD); and to contribute to the accumulation of data on cognitive outcome in preschool children with developmental delay. Analysis revealed that mean initial cognitive score (IQ1) was 64.9 +/- 16.9 while mean cognitive measure at follow-up (IQ2) was 72.2 +/- 19.7. Whole group analysis showed the correlation between IQ1 and IQ2 was moderate (r = 0.73, p < 0.001). Analysis by a general linear model showed only male gender (beta = 4.95, p = 0.02, C.I. = 0.8-9.1) and IQ1 (beta = 0.79, p < 0.001, C.I. = 0.68-0.90) to be significant predictors of IQ2. There were differences among three groups in IQ1 (p < 0.001), IQ2 (p < 0.001) and IQ change (p < 0.001). Correlation coefficients of IQ1 and IQ2 were 0.6 for ASD group, 0.7 for MR group and 0.4 for DLD group respectively. The greatest proportion of children remained within the same cognitive range for both assessment points, however, it is noted that a substantial minority of children changed IQ ranges drastically from preschool through early childhood. Our results suggest that measurements of cognitive function at preschool age for children With developmental delay were valid in the context of a developing country, and the observed change in cognitive scores during follow-up emphasized the need to interpret the initial results of cognitive tests with caution. (C) 2010 Elsevier Ltd. All rights reserved.
C1 [Yang, Pinchen] Kaohsiung Med Univ, Dept Psychiat, Kaohsiung, Taiwan.
[Jong, Yuh-Jyh; Hsu, Hsiu-Yi] Kaohsiung Med Univ Hosp, Dept Pediat & Lab Med, Kaohsiung, Taiwan.
[Lung, For-Wey] Kaohsiung Armed Forces Gen Hosp, Dept Psychiat, Kaohsiung, Taiwan.
[Lung, For-Wey] Kaohsiung Med Univ, Dept Neurol, Kaohsiung, Taiwan.
[Lung, For-Wey] Natl Def Med Ctr, Dept Psychiat, Taipei, Taiwan.
[Jong, Yuh-Jyh] Kaohsiung Med Univ, Grad Inst Med, Coll Med, Kaohsiung, Taiwan.
[Chen, Cheng-Chung] Kaohsiung Kai Suan Psychiat Hosp, Kaohsiung 802, Taiwan.
RP Chen, CC (reprint author), 130 Kai Suan 2nd RD, Kaohsiung 802, Taiwan.
EM pichya@kmu.edu.tw
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NR 36
TC 8
Z9 8
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0891-4222
J9 RES DEV DISABIL
JI Res. Dev. Disabil.
PD JUL-AUG
PY 2010
VL 31
IS 4
BP 895
EP 902
DI 10.1016/j.ridd.2010.02.011
PG 8
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA 601OR
UT WOS:000278072200004
PM 20346615
ER
PT J
AU Gondalia, SV
Palombo, EA
Knowles, SR
Austin, DW
AF Gondalia, Shakuntla V.
Palombo, Enzo A.
Knowles, Simon R.
Austin, David W.
TI Gastrointestinal microbiology in autistic spectrum disorder: a review
SO REVIEWS IN MEDICAL MICROBIOLOGY
LA English
DT Review
ID CONGENITAL CYTOMEGALOVIRUS-INFECTION; BLOOD-BRAIN-BARRIER;
INFANTILE-AUTISM; ONSET AUTISM; CLOSTRIDIUM-DIFFICILE; EPIDEMIOLOGIC
SURVEY; POSTNATAL FACTORS; MEASLES-VIRUS; IN-VITRO; CHILDREN
AB Cases of autism have frequently been reported in association with gastrointestinal problems. These observations have stimulated investigations into possible abnormalities of intestinal microbiota in autistic patients. The objectives of this paper were to review the possible involvement and mechanisms of gastrointestinal microbiota in autistic spectrum disorder and explain the possible role of gastrointestinal microbiota in the condition. This review addresses the possible involvement of bacteria, viruses and fungi, and their products in autism. Direct viral damage of neurons or disruption of normal neurodevelopment by immune elements such as cytokines, nitric oxide and bacterial products, including lipopolysaccharides, toxins and metabolites, have been suggested to contribute to autistic pathology. Numerous intestinal microbial abnormalities have been reported in individuals with autism. Research to date exploring possible gastrointestinal problems and infection in autism has been limited by small and heterogeneous samples, study design flaws and conflicting results. Furthermore, interventions designed to modify the intestinal microbial population of autistic patients are few and limited in their generalisation. In order to bring clarity to this field, high-quality and targeted investigations are needed to explore the role of gastrointestinal microbiology in autism. To this end, several promising avenues for future research are suggested. (C) 2010 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins
C1 [Gondalia, Shakuntla V.; Palombo, Enzo A.; Knowles, Simon R.; Austin, David W.] Swinburne Univ Technol, Fac Life & Social Sci, SABRI, Melbourne, Vic, Australia.
[Palombo, Enzo A.] Swinburne Univ Technol, Fac Life & Social Sci, Environm & Biotechnol Ctr, Melbourne, Vic, Australia.
[Knowles, Simon R.] Swinburne Univ Technol, Fac Life & Social Sci, Swin PSYCHE Unit, Melbourne, Vic, Australia.
RP Gondalia, SV (reprint author), Swinburne Univ Technol, Fac Life & Social Sci, Mail H29,POB 218, Hawthorn, Vic 3122, Australia.
EM sgondalia@swin.edu.au
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NR 85
TC 4
Z9 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0954-139X
J9 REV MED MICROBIOL
JI Rev. Med. Microbiol.
PD JUL
PY 2010
VL 21
IS 3
BP 44
EP 50
DI 10.1097/MRM.0b013e32833a3dc9
PG 7
GA 622HC
UT WOS:000279651000002
ER
PT J
AU Fatemi, SH
Folsom, TD
Reutiman, TJ
Braun, NN
Lavergne, LG
AF Fatemi, S. Hossein
Folsom, Timothy D.
Reutiman, Teri J.
Braun, Natalie N.
Lavergne, Luke G.
TI Levels of Phosphodiesterase 4A and 4B Are Altered by Chronic Treatment
With Psychotropic Medications in Rat Frontal Cortex
SO SYNAPSE
LA English
DT Article
DE phosphodiesterase 4A; phosphodiesterase 4B; schizophrenia; rat; frontal
cortex
ID REPEATED ANTIDEPRESSANT TREATMENT; CAUSES DIFFERENTIAL EXPRESSION;
CHRONIC OLANZAPINE TREATMENT; IN-SITU HYBRIDIZATION; CHRONIC
HALOPERIDOL; BRAIN; SCHIZOPHRENIA; GENES; PDE4B; MORPHOGENESIS
AB Our laboratory has recently demonstrated altered expression of phosphodiesterase (PDE) 4A and 4B in subjects with autism, bipolar disorder, and schizophrenia, suggesting disrupted cAMP signaling in these diagnostic groups. In the current study, we measured expression of PDEs in rat frontal cortex (FC) following chronic treatment with clozapine, fluoxetine, haloperidol, lithium, olanzapine, valproic acid (VPA), or sterile saline for 21 days. Western blotting experiments showed decreased expression of PDE4A subtypes in FC following treatment with clozapine, haloperidol, lithium, and VPA. PDE4B subtypes were similarly reduced in FC following treatment with clozapine, fluoxetine, and lithium. We also measured levels of nine PDE subtypes via qRT-PCR in FC and found significant upregulation of PDE1A and PDE8B following treatment with olanzapine, while treatment with lithium reduced expression of mRNA for PDE8B. Our results demonstrate altered expression of PDE4A and PDE4B in response to a variety of psychotropic medications suggesting potentially new therapeutic avenues for treatment of neuropsychiatric diseases. Synapse 64:550-555, 2010. (C) 2010 Wiley-Liss, Inc.
C1 [Fatemi, S. Hossein; Folsom, Timothy D.; Reutiman, Teri J.; Braun, Natalie N.; Lavergne, Luke G.] Univ Minnesota, Sch Med, Dept Psychiat, Div Neurosci Res, Minneapolis, MN 55455 USA.
[Fatemi, S. Hossein] Univ Minnesota, Sch Med, Dept Pharmacol, Minneapolis, MN 55455 USA.
[Fatemi, S. Hossein] Univ Minnesota, Sch Med, Dept Neurosci, Minneapolis, MN 55455 USA.
RP Fatemi, SH (reprint author), 420 Delaware St SE,MMC 392, Minneapolis, MN 55455 USA.
EM fatem002@umn.edu
FU Stanley Medical Research Institute [06R-1406]
FX Contract grant sponsor: Stanley Medical Research Institute; Contract
grant number: 06R-1406.
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NR 30
TC 5
Z9 5
PU WILEY-LISS
PI HOBOKEN
PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 0887-4476
J9 SYNAPSE
JI Synapse
PD JUL
PY 2010
VL 64
IS 7
BP 550
EP 555
DI 10.1002/syn.20762
PG 6
WC Neurosciences
SC Neurosciences & Neurology
GA 600CL
UT WOS:000277961200008
PM 20222156
ER
PT J
AU Debes, R
AF Debes, Remy
TI Which empathy? Limitations in the mirrored "understanding" of emotion
SO SYNTHESE
LA English
DT Article
DE Empathy; Mirroring; Mirror neurons; Mindreading
ID SOCIAL COGNITION; PREMOTOR CORTEX; NEURON SYSTEM; ACTION RECOGNITION;
MOTOR; IMITATION; MECHANISMS; OTHERS; AUTISM; HUMANS
AB The recent discovery of so-called "mirror-neurons" in monkeys and a corresponding mirroring "system" in humans has provoked wide endorsement of the claim that humans understand a variety of observed actions, somatic sensations, and emotions via a kind of direct representation of those actions, sensations, and emotions. Philosophical efforts to assess the import of such "mirrored understanding" have typically focused on how that understanding might be brought to bear on theories of mindreading (how we represent other creatures as having mental states), and usually in cases of action. By contrast, this paper assesses mirrored understanding in cases of emotion and its import for theories of empathy and especially empathy in ethical contexts. In particular, this paper argues that the mirrored understanding claim is ambiguous and ultimately misleading when applied to emotion, partly because mirroring proponents fail to appreciate the way in which empathy might serve a distinct normative function in our judgments of what other people feel. The paper thus concludes with a call to revise the mirrored understanding claim, whether in neuroscience, psychology, or philosophy.
C1 Univ Memphis, Memphis, TN 38152 USA.
RP Debes, R (reprint author), Univ Memphis, Memphis, TN 38152 USA.
EM rdebes@memphis.edu
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NR 41
TC 4
Z9 4
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0039-7857
J9 SYNTHESE
JI Synthese
PD JUL
PY 2010
VL 175
IS 2
BP 219
EP 239
DI 10.1007/s11229-009-9499-7
PG 21
WC History & Philosophy Of Science; Philosophy
SC History & Philosophy of Science; Philosophy
GA 634KM
UT WOS:000280579800005
ER
PT J
AU Baharav, E
Reiser, C
AF Baharav, Eva
Reiser, Carly
TI Using Telepractice in Parent Training in Early Autism
SO TELEMEDICINE JOURNAL AND E-HEALTH
LA English
DT Article
DE telemedicine; telehealth; distance learning
ID YOUNG-CHILDREN; INTERVENTION
AB There is a growing body of literature indicating that intense early intervention is current best practice for treating children with autism spectrum disorders (ASD). Several studies demonstrate the effectiveness of parents as agents of intervention in the child's home environment. However, this approach requires intense one-on-one supervision by highly trained professionals. Consequently, there is a significant gap between the intensive service requirements for children with ASD and the available resources to provide these services. In the current pilot study, the use of remote technology, telepractice, is evaluated as a tool for coaching parents of two children found to have ASD. Two clinical models of intervention are compared: a traditional model of twice-weekly speech and language therapy sessions (traditional clinical model) and a model where a once-a-week clinical session is followed by a home-based session administered by the parents and remotely supervised and coached by the clinician (clinic/telepractice model). Results suggest that gains obtained in traditional therapy can be maintained and even exceeded in a treatment model that uses telepractice. Parents reported that they perceived telepractice sessions to be as valuable as those delivered directly by the clinician, felt comfortable using the technology, and were willing to continue intervention with their children at home. These preliminary results suggest that use of telepractice holds promise for reducing the demands on available resources of service for this population. A study with a larger population is currently underway including cost-benefit analyses to examine the implications for such a treatment model to its users and to the healthcare system.
C1 [Baharav, Eva; Reiser, Carly] Western Washington Univ, Dept Commun Sci & Disorders, Speech Language Hearing Clin, Bellingham, WA 98225 USA.
RP Baharav, E (reprint author), Western Washington Univ, Dept Commun Sci & Disorders, Speech Language Hearing Clin, 516 High St, Bellingham, WA 98225 USA.
EM eva.baharav@wwu.edu
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*CDCP, AUT SPECTR DIS NEW A
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NR 11
TC 7
Z9 7
PU MARY ANN LIEBERT INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1530-5627
J9 TELEMED J E-HEALTH
JI Telemed. J. e-Health
PD JUL-AUG
PY 2010
VL 16
IS 6
BP 727
EP 731
DI 10.1089/tmj.2010.0029
PG 5
WC Health Care Sciences & Services
SC Health Care Sciences & Services
GA 635PV
UT WOS:000280669500049
PM 20583950
ER
PT J
AU [Anonymous]
AF [Anonymous]
TI Urine test could predict autism earlier
SO TRAC-TRENDS IN ANALYTICAL CHEMISTRY
LA English
DT News Item
CR Yap IKS, 2010, J PROTEOME RES, V9, P2996, DOI 10.1021/pr901188e
NR 1
TC 0
Z9 0
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0165-9936
J9 TRAC-TREND ANAL CHEM
JI Trac-Trends Anal. Chem.
PD JUL-AUG
PY 2010
VL 29
IS 7
SI SI
BP V
EP VI
PG 2
WC Chemistry, Analytical
SC Chemistry
GA 639UZ
UT WOS:000281001600002
ER
PT J
AU Bozkurt, H
Mukaddes, NM
AF Bozkurt, Hasan
Mukaddes, Nahit Motavalli
TI Catatonia in a child with autistic disorder
SO TURKISH JOURNAL OF PEDIATRICS
LA English
DT Article
DE catatonia; children; autism; lorazepam
ID ELECTROCONVULSIVE-THERAPY; ARIPIPRAZOLE; OLANZAPINE; SUBTYPE
AB Bozkurt H, Mukaddes NM. Catatonia in a child with autistic disorder. Turk J Pediatr 2010; 52: 435-438.
Catatonia is a cluster of motor features that appears in many recognized psychiatric illnesses. It is being increasingly reported in individuals with autism, a disorder characterized by impaired reciprocal social interactions, aberrant language development and restricted behavioral repertoire. However, relatively little is known about the presentation and treatment of catatonia in children with autism. We describe herein an 11-year-old pediatric case with autism who developed catatonic symptoms and was treated effectively with lorazepam. The case reported here differs from previously reported cases in terms of age of onset and the display of all characteristics of catatonia as defined in the Diagnostic and Statistical Manual of Mental Disorders (4th ed) (DSM-IV). In addition, although it was stated that catatonia in autism is commonly associated with impaired language and social passivity, our case is an active verbal individual.
C1 [Bozkurt, Hasan; Mukaddes, Nahit Motavalli] Istanbul Univ, Istanbul Fac Med, Dept Child & Adolescent Psychiat, Istanbul, Turkey.
RP Bozkurt, H (reprint author), Istanbul Univ, Istanbul Fac Med, Dept Child & Adolescent Psychiat, Istanbul, Turkey.
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NR 17
TC 5
Z9 5
PU TURKISH J PEDIATRICS
PI ANKARA
PA P K 66 SAMANPAZARI, 06240 ANKARA, TURKEY
SN 0041-4301
J9 TURKISH J PEDIATR
JI Turk. J. Pediatr.
PD JUL-AUG
PY 2010
VL 52
IS 4
BP 435
EP 438
PG 4
WC Pediatrics
SC Pediatrics
GA 671AB
UT WOS:000283470400019
PM 21043395
ER
PT J
AU Chaudhuri, S
Chakraborty, S
Sengupta, PK
AF Chaudhuri, Sudip
Chakraborty, Sandipan
Sengupta, Pradeep K.
TI Encapsulation of serotonin in beta-cyclodextrin nano-cavities:
Fluorescence spectroscopic and molecular modeling studies
SO JOURNAL OF MOLECULAR STRUCTURE
LA English
DT Article
DE Serotonin; SHP beta-cyclodextrin; Fluorescence intensity; Fluorescence
anisotropy; Molecular docking; Semiempirical methods
ID INTRAMOLECULAR CHARGE-TRANSFER; INCLUSION COMPLEXES; EXCITED-STATE;
MECHANICS; ENVIRONMENTS; DERIVATIVES; ENERGY
AB Serotonin is a physiologically important biogenic amine, deficiency of which leads to mental disorders such as Alzheimer's disease, schizophrenia, infantile autism, and depression. Both beta-cyclodextrin (beta-CD) and its chemically substituted synthetic varieties (often possessing enhanced aqueous solubility and improved drug complexing abilities) are finding wide applications as drug delivery vehicles. Here we have studied the encapsulation of serotonin in beta-CD and succinyl-2-hydroxypropyl p-cyclodextrin (SHP-beta-CD) by exploiting the intrinsic serotonin fluorescence. Enhanced fluorescence emission intensity (which increases by similar to 18% and 34% in beta-CD and SHP beta-CD respectively) and anisotropy (r) (r = 0.075 and 0.1 in beta-CD and SHP beta-CD respectively) are observed in presence of the cyclodextrins. From the fluorescence data host-guest interaction with 1:1 stoichiometry is evident, the association constants (K) being 126.06 M-1 and 461.62 M-1 for beta-CD and SHP beta-CD respectively. Additionally, molecular docking and semiempirical calculations have been carried out which provide, for the first time, detailed insights regarding the encapsulation process. In particular, it is evident that the indole ring is inserted within the beta-CD cavity with the aliphatic amine side chain protruding towards the primary rim of the beta-CD cavity. Docking calculations reveal that hydrogen bonding interactions are involved in the formation of the inclusion complex. Semiempirical calculations indicate that formation of the 1:1 inclusion complex is energetically favorable which is consistent with the fluorescence data. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Chaudhuri, Sudip; Chakraborty, Sandipan; Sengupta, Pradeep K.] Saha Inst Nucl Phys, Div Biophys, Kolkata 700064, India.
[Chaudhuri, Sudip] Gandhi Centenary BT Coll, Habra, India.
RP Sengupta, PK (reprint author), Saha Inst Nucl Phys, Div Biophys, 1-AF Bidhannagar, Kolkata 700064, India.
EM pradeepk.sengupta@saha.ac.in
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NR 32
TC 27
Z9 28
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0022-2860
EI 1872-8014
J9 J MOL STRUCT
JI J. Mol. Struct.
PD JUN 30
PY 2010
VL 975
IS 1-3
BP 160
EP 165
DI 10.1016/j.molstruc.2010.04.014
PG 6
WC Chemistry, Physical
SC Chemistry
GA 627GX
UT WOS:000280028600023
ER
PT J
AU Yoshida, W
Dziobek, I
Kliemann, D
Heekeren, HR
Friston, KJ
Dolan, RJ
AF Yoshida, Wako
Dziobek, Isabel
Kliemann, Dorit
Heekeren, Hauke R.
Friston, Karl J.
Dolan, Ray J.
TI Cooperation and Heterogeneity of the Autistic Mind
SO JOURNAL OF NEUROSCIENCE
LA English
DT Article
ID HIGH-FUNCTIONING AUTISM; SOCIAL DECISION-MAKING; DIAGNOSTIC INTERVIEW;
NEURAL BASIS; GAME-THEORY; NEUROSCIENCE; DISORDER; CORTEX; BRAIN; SELF
AB Individuals with autism spectrum conditions (ASCs) have a core difficulty in recursively inferring the intentions of others. The precise cognitive dysfunctions that determine the heterogeneity at the heart of this spectrum, however, remains unclear. Furthermore, it remains possible that impairment in social interaction is not a fundamental deficit but a reflection of deficits in distinct cognitive processes. To better understand heterogeneity within ASCs, we employed a game-theoretic approach to characterize unobservable computational processes implicit in social interactions. Using a social hunting game with autistic adults, we found that a selective difficulty representing the level of strategic sophistication of others, namely inferring others' mindreading strategy, specifically predicts symptom severity. In contrast, a reduced ability in iterative planning was predicted by overall intellectual level. Our findings provide the first quantitative approach that can reveal the underlying computational dysfunctions that generate the autistic "spectrum."
C1 [Yoshida, Wako; Friston, Karl J.; Dolan, Ray J.] UCL, Inst Neurol, Wellcome Trust Ctr Neuroimaging, London WC1N 3BG, England.
[Kliemann, Dorit; Heekeren, Hauke R.] Free Univ Berlin, Dept Educ Sci & Psychol, D-14195 Berlin, Germany.
[Kliemann, Dorit; Heekeren, Hauke R.] Max Planck Inst Human Dev, D-14195 Berlin, Germany.
RP Yoshida, W (reprint author), UCL, Inst Neurol, Wellcome Trust Ctr Neuroimaging, 12 Queen Sq, London WC1N 3BG, England.
EM w.yoshida@fil.ion.ucl.ac.uk
RI Friston, Karl/D-9230-2011; Heekeren, Hauke/B-7739-2008
OI Friston, Karl/0000-0001-7984-8909; Heekeren, Hauke/0000-0001-7912-6826
FU Wellcome Trust
FX This work was supported by Wellcome Trust Programme grants to R.J.D. and
K.J.F.
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TC 28
Z9 29
PU SOC NEUROSCIENCE
PI WASHINGTON
PA 11 DUPONT CIRCLE, NW, STE 500, WASHINGTON, DC 20036 USA
SN 0270-6474
J9 J NEUROSCI
JI J. Neurosci.
PD JUN 30
PY 2010
VL 30
IS 26
BP 8815
EP 8818
DI 10.1523/JNEUROSCI.0400-10.2010
PG 4
WC Neurosciences
SC Neurosciences & Neurology
GA 621LY
UT WOS:000279581500014
PM 20592203
ER
PT J
AU Sharda, M
Subhadra, TP
Sahay, S
Nagaraja, C
Singh, L
Mishra, R
Sen, A
Singhal, N
Erickson, D
Singh, NC
AF Sharda, Megha
Subhadra, T. Padma
Sahay, Sanchita
Nagaraja, Chetan
Singh, Latika
Mishra, Ramesh
Sen, Amit
Singhal, Nidhi
Erickson, Donna
Singh, Nandini C.
TI Sounds of melody-Pitch patterns of speech in autism
SO NEUROSCIENCE LETTERS
LA English
DT Article
DE Autism; Speech; Prosody; Pitch; Intonation contours; Motherese
ID HIGH-FUNCTIONING AUTISM; SPECTRUM DISORDERS; PROSODY; INTONATION;
MOTHERESE; LANGUAGE; EMOTION; INFANTS
AB The objective of this study was to find a pattern in vocalizations of children with Autism Spectrum Disorder (ASD). We compared the intonational features of 15 children with ASD who showed speech, aged 4-10 years, with 10 age-matched typically developing controls. Exaggerated pitch, pitch range, pitch excursion and pitch contours were observed in speech of children with autism, but absent in age-matched controls. These exaggerated features, which are distinctive characteristics of motherese, were also seen in interactions of an independent group of 8 mothers of typical infants using child-directed speech. Our findings provide the first evidence of a distinct pattern in vocal output from children with autism. They also demonstrate that speech patterns might follow a delayed developmental trajectory in these children. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
C1 [Sharda, Megha; Subhadra, T. Padma; Sahay, Sanchita; Nagaraja, Chetan; Singh, Latika; Mishra, Ramesh; Singh, Nandini C.] Natl Brain Res Ctr, Nainwal Mode 122050, Manesar, India.
[Sen, Amit] Sitaram Bhartia Inst Sci & Res, Qutub Inst Area B 16, New Delhi 110016, India.
[Singhal, Nidhi] Natl Ctr Autism, Act Autism, New Delhi 110025, India.
[Erickson, Donna] Showa Mus Univ, Kawasaki, Kanagawa 2158558, Japan.
RP Singh, NC (reprint author), Natl Brain Res Ctr, NH 8, Nainwal Mode 122050, Manesar, India.
EM nandini@nbrc.ac.in
FU National Brain Research Centre; Department of Information Technology,
Government of India
FX This research was funded by the National Brain Research Centre and the
Department of Information Technology, Government of India. The authors
would like to thank the children and mothers who participated in the
study; Shobha Srinath and N. Shivshankar, from the National Institute
for Mental Health and Neurosciences, India for providing data.
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NR 24
TC 11
Z9 11
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
IRELAND
SN 0304-3940
J9 NEUROSCI LETT
JI Neurosci. Lett.
PD JUN 30
PY 2010
VL 478
IS 1
BP 42
EP 45
DI 10.1016/j.neulet.2010.04.066
PG 4
WC Neurosciences
SC Neurosciences & Neurology
GA 615UZ
UT WOS:000279164600010
PM 20447444
ER
PT J
AU Schimansky, J
David, N
Rossler, W
Haker, H
AF Schimansky, Jenny
David, Nicole
Roessler, Wulf
Haker, Helene
TI Sense of agency and mentalizing: Dissociation of subdomains of social
cognition in patients with schizophrenia
SO PSYCHIATRY RESEARCH
LA English
DT Article
DE Sense of agency; Mentalizing; Self-other distinction; Action monitoring;
Theory of mind; Perspective taking
ID ERROR-CORRECTING BEHAVIOR; HIGH-FUNCTIONING AUTISM; ASPERGER-SYNDROME;
ATTRIBUTION THEORY; NEURAL MECHANISMS; SELF-RECOGNITION; ALIEN CONTROL;
1ST EPISODE; AMDP SYSTEM; MIND
AB The sense of agency, i.e., the sense that "I am the one who is causing an action", and mentalizing, the ability to understand the mental states of other individuals, are key domains of social cognition. It has been hypothesized that an intact sense of agency is an important precondition for higher-level mentalizing abilities. A substantial body of evidence shows that both processes rely on similar brain areas and are severely impaired in schizophrenia, suggesting a close link between agency and mentalizing. Yet this relationship has not been explicitly tested. We investigated 40 individuals with schizophrenia and 40 healthy controls on an agency and mentalizing task. On the agency task, participants carried out simple mouse movements and judged the partially manipulated visual feedback as either self- or other-generated. On the mentalizing task, participants inferred mental states from pictures that depicted others' eyes ("Reading the mind in the eyes test"). Neuropsychological, psychopathological and social functioning levels were also evaluated. Both sense of agency and mentalizing were impaired in schizophrenia patients compared to healthy controls. However, testing for a relationship revealed no significant correlations between the two processes, either in the schizophrenia or the control group. The present findings demonstrate a dissociation of agency and mentalizing deficits in schizophrenia, suggesting that the multifaceted construct of social cognition consists of independent subdomains in healthy and psychiatrically ill individuals. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
C1 [Schimansky, Jenny; Roessler, Wulf; Haker, Helene] Psychiat Univ Hosp, Dept Gen & Social Psychiat, CH-8021 Zurich, Switzerland.
[David, Nicole] Univ Med Ctr Hamburg Eppendorf, Dept Neurophysiol & Pathophysiol, Hamburg, Germany.
RP Schimansky, J (reprint author), Psychiat Univ Hosp, Dept Gen & Social Psychiat, Militarstr 8,POB 1930, CH-8021 Zurich, Switzerland.
EM jenny.schimansky@dgsp.uzh.ch
RI David, Nicole/H-1682-2012
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TC 9
Z9 9
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
IRELAND
SN 0165-1781
J9 PSYCHIAT RES
JI Psychiatry Res.
PD JUN 30
PY 2010
VL 178
IS 1
BP 39
EP 45
DI 10.1016/j.psychres.2010.04.002
PG 7
WC Psychiatry
SC Psychiatry
GA 620HI
UT WOS:000279489400007
PM 20452061
ER
PT J
AU Gooding, DC
Johnson, M
Peterman, JS
AF Gooding, Diane Carol
Johnson, Madeline
Peterman, Joel Stephen
TI Schizotypy and altered digit ratios: A second look
SO PSYCHIATRY RESEARCH
LA English
DT Article
DE Schizotypy; Digit ratios; Theory of Mind; 2D:4D
ID SOCIAL ANHEDONIA; SPECTRUM DISORDERS; TEMPORAL-LOBE; EYES TEST;
SCHIZOPHRENIA; MIND; AUTISM; RISK; SCALES; 2D4D
AB Alterations in the ratio between the 2nd and 4th finger digits have been posited as a potential indicator of increased liability for neurodevelopmental disorders such as autism and schizophrenia. We compared digit ratios in two groups of psychometrically-identified schizotypes, namely, those characterized by positive schizotypy (perceptual aberrations and magical ideation; n = 76) and those characterized by negative schizotypy (social anhedonia; n = 64), to a control group (n = 110). The groups were also compared in terms of their performance on a measure of Theory of Mind, namely, the Reading the Mind in the Eyes Test (RMET) and trait affect, as measured by the PANAS. Our results indicate that neither negative schizotypy nor positive schizotypy is associated with altered digit ratios. Similarly, the groups showed no significant differences on the RMET. However, we observed a small but significant inverse association between Theory of Mind performance and negative affect. The findings are considered in light of the extant literature. These results call into question the viability of altered digit ratios to serve as an indicator of increased risk for schizophrenia-spectrum disorders. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
C1 [Gooding, Diane Carol; Johnson, Madeline; Peterman, Joel Stephen] Univ Wisconsin, Dept Psychol, Madison, WI 53706 USA.
[Gooding, Diane Carol] Univ Wisconsin, Dept Psychiat, Madison, WI 53706 USA.
RP Gooding, DC (reprint author), Univ Wisconsin, Dept Psychol, 1202 W Johnson St, Madison, WI 53706 USA.
EM dgooding@wisc.edu
FU WARF
FX This research was funded by a WARF Hilldale Undergraduate-Faculty
Research Fellowship (DCG, JSP). We thank Dr. Simon Baron-Cohen and the
Autism Research Centre for the use of the Reading the Mind in the Eyes
Test. Portions of these data were presented at the 2009 meeting of the
Society for Research in Psychopathology. Minneapolis, Minnesota.
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NR 49
TC 8
Z9 8
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
IRELAND
SN 0165-1781
J9 PSYCHIAT RES
JI Psychiatry Res.
PD JUN 30
PY 2010
VL 178
IS 1
BP 73
EP 78
DI 10.1016/j.psychres.2010.04.023
PG 6
WC Psychiatry
SC Psychiatry
GA 620HI
UT WOS:000279489400013
PM 20471104
ER
PT J
AU Yang, SY
Cho, SC
Yoo, HJ
Cho, IH
Park, M
Yoe, J
Kim, SA
AF Yang, So Young
Cho, Soo-Churl
Yoo, Hee Jeong
Cho, In Hee
Park, Mira
Yoe, Jin
Kim, Soon Ae
TI Family-based association study of microsatellites in the 5 ' flanking
region of AVPR1A with autism spectrum disorder in the Korean population
SO PSYCHIATRY RESEARCH
LA English
DT Article
DE Autism spectrum disorder (ASD); AVPR1A; Association
ID VASOPRESSIN; GENE; BEHAVIOR
AB This study evaluated the association between autism spectrum disorders (ASDs) and microsatellites (RS3 and RS1) in the 5' flanking region of AVPR1A in 148 Korean trios comprising children with ASDs. In the transmission equilibrium test and haplotype analysis, we found a statistically significant association between microsatellites and Korean ASDs. Crown Copyright (C) 2009 Published by Elsevier Ireland Ltd. All rights reserved.
C1 [Yang, So Young; Yoe, Jin; Kim, Soon Ae] Eulji Univ, Dept Pharmacol, Sch Med, Taejon 301746, South Korea.
[Cho, Soo-Churl] Seoul Natl Univ, Coll Med, Dept Psychiat, Seoul Natl Univ Hosp, Seoul, South Korea.
[Yoo, Hee Jeong] Seoul Natl Univ, Bundang Hosp, Dept Psychiat, Songnam, Kyeonggi, South Korea.
[Cho, In Hee] Gachon Univ Med & Sci, Dept Psychiat, Gil Med Ctr, Inchon, South Korea.
[Park, Mira] Eulji Univ, Dept Prevent Med, Sch Med, Taejon 301746, South Korea.
[Kim, Soon Ae] Eulji Univ, Med Sci Res Inst, Taejon 301746, South Korea.
RP Kim, SA (reprint author), Eulji Univ, Dept Pharmacol, Sch Med, 143-5 Yongdu Dong, Taejon 301746, South Korea.
EM sakim@eulji.ac.kr
RI Yoo, Hee Jeong/J-5555-2012
FU Ministry of Health and Welfare, Republic of Korea [A080651]
FX This study was supported by a grant from the Korea Healthcare Technology
R&D Project, Ministry of Health and Welfare, Republic of Korea
(A080651).
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Yoo HJ, 2007, KOREAN VERSION AUTIS
NR 9
TC 9
Z9 9
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
IRELAND
SN 0165-1781
J9 PSYCHIAT RES
JI Psychiatry Res.
PD JUN 30
PY 2010
VL 178
IS 1
BP 199
EP 201
DI 10.1016/j.psychres.2009.11.007
PG 3
WC Psychiatry
SC Psychiatry
GA 620HI
UT WOS:000279489400037
PM 20452058
ER
PT J
AU Adler, N
Nadler, B
Eviatar, Z
Shamay-Tsoory, SG
AF Adler, Noga
Nadler, Benny
Eviatar, Zohar
Shamay-Tsoory, Simone G.
TI The relationship between theory of mind and autobiographical memory in
high-functioning autism and Asperger syndrome
SO PSYCHIATRY RESEARCH
LA English
DT Article
DE Autism; Autobiographical memory; Theory of mind
ID CHILDREN; ADULTS
AB The relationship between theory of mind (ToM) and autobiographical memory (AM) in high-functioning autism (HFA) and Asperger syndrome (AS) has never been investigated. Here, we show that ToM abilities could be predicted by levels of AM in HFA and AS as compared to controls, suggesting that difficulties in AM are closely related to ToM impairments in HFA and AS. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
C1 [Adler, Noga; Nadler, Benny; Eviatar, Zohar; Shamay-Tsoory, Simone G.] Univ Haifa, Dept Psychol, IL-31905 Haifa, Israel.
RP Shamay-Tsoory, SG (reprint author), Univ Haifa, Dept Psychol, IL-31905 Haifa, Israel.
EM sshamay@psy.haifa.ac.il
CR American Psychiatric Association [APA], 1994, DSM 4 DIAGN STAT MAN
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TAGERFLUSBERG H, 2001, DEV AUTISM PERSPECTI
NR 14
TC 17
Z9 18
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
IRELAND
SN 0165-1781
J9 PSYCHIAT RES
JI Psychiatry Res.
PD JUN 30
PY 2010
VL 178
IS 1
BP 214
EP 216
DI 10.1016/j.psychres.2009.11.015
PG 3
WC Psychiatry
SC Psychiatry
GA 620HI
UT WOS:000279489400042
PM 20452047
ER
PT J
AU Tanimura, Y
Vaziri, S
Lewis, MH
AF Tanimura, Yoko
Vaziri, Sasha
Lewis, Mark H.
TI Indirect basal ganglia pathway mediation of repetitive behavior:
Attenuation by adenosine receptor agonists
SO BEHAVIOURAL BRAIN RESEARCH
LA English
DT Article
DE Autism; Stereotypy; Subthalamic nucleus; Neurodevelopmental disorders;
Deer mice; Animal models
ID HIGH-FREQUENCY STIMULATION; DEEP BRAIN-STIMULATION; SUBTHALAMIC NUCLEUS;
RAT STRIATUM; SPONTANEOUS STEREOTYPY; ENVIRONMENTAL ENRICHMENT;
HUNTINGTONS-DISEASE; ANTAGONIST KW-6002; DOPAMINE RELEASE;
GENE-EXPRESSION
AB Repetitive behaviors are diagnostic for autism and common in related neurodevelopmental disorders. Despite their clinical importance, underlying mechanisms associated with the expression of these behaviors remain poorly understood. Our lab has previously shown that the rates of spontaneous stereotypy in deer mice (Peromyscus maniculatus) were negatively correlated with enkephalin content, a marker of striatopallidal but not striatonigral neurons. To investigate further the role of the indirect basal ganglia pathway, we examined neuronal activation of the subthalamic nucleus (STN) using cytochrome oxidase (CO) histochemistry in high- and low-stereotypy mice. CO activity in STN was significantly lower in high-stereotypy mice and negatively correlated with the frequency of stereotypy. In addition, exposure to environmental enrichment, which attenuated stereotypy, normalized the activity of STN. Co-administration of the adenosine A(2A) receptor agonist CGS21680 and the AI receptor agonist CPA attenuated stereotypy dose-dependently. The significant reduction associated with the lowest dose of the drug combination tested was due to its effects on mice with lower baseline levels of stereotypy. Higher doses of the drug combination were required to show robust behavioral effects, and presumably requisite activation of the indirect pathway, in high-stereotypy mice. These findings support that decreased indirect pathway activity is linked to the expression of high levels of stereotypy in deer mice and that striatal A(1) and A(2A) receptors may provide promising therapeutic targets for the treatment of repetitive behaviors in neurodevelopmental disorders. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Lewis, Mark H.] Univ Florida, McKnight Brain Inst, Dept Psychiat, Gainesville, FL 32611 USA.
Univ Florida, Dept Psychol, McKnight Brain Inst, Gainesville, FL 32611 USA.
RP Lewis, MH (reprint author), Univ Florida, McKnight Brain Inst, Dept Psychiat, 100 S Newell Dr L4-116, Gainesville, FL 32611 USA.
EM marklewis@ufl.edu
RI Tanimura, Yoko/D-3141-2014
FU NIH [MH080055]
FX This work was supported by NIH grant MH080055.
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NR 61
TC 18
Z9 18
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0166-4328
J9 BEHAV BRAIN RES
JI Behav. Brain Res.
PD JUN 26
PY 2010
VL 210
IS 1
BP 116
EP 122
DI 10.1016/j.bbr.2010.02.030
PG 7
WC Behavioral Sciences; Neurosciences
SC Behavioral Sciences; Neurosciences & Neurology
GA 597YQ
UT WOS:000277798900015
PM 20178817
ER
PT J
AU Puzzo, I
Cooper, NR
Vetter, P
Russo, R
AF Puzzo, Ignazio
Cooper, Nicholas R.
Vetter, Petra
Russo, Riccardo
TI EEG activation differences in the pre-motor cortex and supplementary
motor area between normal individuals with high and low traits of autism
SO BRAIN RESEARCH
LA English
DT Article
DE EEG; Social cognition; Mirror neuron
ID LIGHT BIOLOGICAL MOTION; MIRROR NEURON ACTIVITY; PACED FINGER MOVEMENT;
HIGH-RESOLUTION EEG; VOLUNTARY MOVEMENT; SPECTRUM DISORDER; MU-RHYTHMS;
SYSTEM; IMITATION; ELECTROENCEPHALOGRAPHY
AB The human mirror neuron system (hMNS) is believed to provide a basic mechanism for social cognition. Event-related desynchronization (ERD) in alpha (8-12 Hz) and low beta band (12-20 Hz) over sensori-motor cortex has been suggested to index mirror neurons' activity. We tested whether autistic traits revealed by high and low scores on the Autistic Quotient (AQ) in the normal population are linked to variations in the electroencephalogram (EEG) over motor, pre-motor cortex and supplementary motor area (SMA) during action observation. Results revealed that in the low AQ group, the pre-motor cortex and SMA were more active during hand action than static hand observation whereas in the high AQ group the same areas were active both during static and hand action observation. In fact participants with high traits of autism showed greater low beta ERD while observing the static hand than those with low traits and this low beta ERD was not significantly different when they watched hand actions. Over primary motor cortex, the classical alpha and low beta ERD during hand actions relative to static hand observation was found across all participants. These findings suggest that the observation-execution matching system works differently according to the degree of autism traits in the normal population and that this is differentiated in terms of the EEG according to scalp site and bandwidth. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Puzzo, Ignazio; Cooper, Nicholas R.; Russo, Riccardo] Univ Essex, Dept Psychol, Colchester CO4 3SQ, Essex, England.
[Vetter, Petra] Univ Glasgow, Dept Psychol, Ctr Cognit Neuroimaging, Glasgow G12 8QB, Lanark, Scotland.
RP Puzzo, I (reprint author), Univ Essex, Dept Psychol, Wivenhoe Pk, Colchester CO4 3SQ, Essex, England.
EM ipuzzo@essex.ac.uk
FU University of Essex
FX This study was supported by a University of Essex studentship to Ignazio
Puzzo and a University of Essex Research Promotion Fund grant to
Nicholas Cooper.
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Ulloa ER, 2007, BEHAV BRAIN RES, V183, P188, DOI 10.1016/j.bbr.2007.06.007
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NR 34
TC 11
Z9 11
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0006-8993
J9 BRAIN RES
JI Brain Res.
PD JUN 25
PY 2010
VL 1342
BP 104
EP 110
DI 10.1016/j.brainres.2010.04.060
PG 7
WC Neurosciences
SC Neurosciences & Neurology
GA 623DF
UT WOS:000279717500011
PM 20435023
ER
PT J
AU Stone, J
AF Stone, John
TI Autism
SO TLS-THE TIMES LITERARY SUPPLEMENT
LA English
DT Letter
RP Stone, J (reprint author), 34 Outram Rd, London N22, England.
NR 0
TC 2
Z9 2
PU TIMES SUPPLEMENTS LIMITED
PI MARKET HARBOROUGH
PA TOWER HOUSE, SOVEREIGN PARK, MARKET HARBOROUGH LE87 4JJ, ENGLAND
SN 0307-661X
J9 TLS-TIMES LIT SUPPL
JI TLS-Times Lit. Suppl.
PD JUN 25
PY 2010
IS 5595
BP 6
EP 6
PG 1
WC Humanities, Multidisciplinary
SC Arts & Humanities - Other Topics
GA 616WB
UT WOS:000279240600007
ER
PT J
AU Falck-Ytter, T
AF Falck-Ytter, Terje
TI Young children with autism spectrum disorder use predictive eye
movements in action observation
SO BIOLOGY LETTERS
LA English
DT Article
DE autism spectrum disorders; mirror neuron system; forward models; action
prediction; eye movements
ID MIRROR NEURON DYSFUNCTION; IMITATION; OTHERS; SYSTEM; GOALS
AB Does a dysfunction in the mirror neuron system (MNS) underlie the social symptoms defining autism spectrum disorder (ASD)? Research suggests that the MNS matches observed actions to motor plans for similar actions, and that these motor plans include directions for predictive eye movements when observing goal-directed actions. Thus, one important question is whether children with ASD use predictive eye movements in action observation. Young children with ASD as well as typically developing children and adults were shown videos in which an actor performed object-directed actions (human agent condition). Children with ASD were also shown control videos showing objects moving by themselves (self-propelled condition). Gaze was measured using a corneal reflection technique. Children with ASD and typically developing individuals used strikingly similar goal-directed eye movements when observing others' actions in the human agent condition. Gaze was reactive in the self-propelled condition, suggesting that prediction is linked to seeing a hand-object interaction. This study does not support the view that ASD is characterized by a global dysfunction in the MNS.
C1 Uppsala Univ, Dept Psychol, S-75142 Uppsala, Sweden.
RP Falck-Ytter, T (reprint author), Uppsala Univ, Dept Psychol, Box 1225, S-75142 Uppsala, Sweden.
EM terje.falck-ytter@psyk.uu.se
FU Bank of Sweden [J2004-0511]; European Union [EU15636: TACT]
FX I am grateful to Claes von Hofsten, Therese Ljunghammar, Gunilla Bohlin
and Ben Kenward for their comments on an earlier version of this paper.
This research was supported by grants to Claes von Hofsten from the
Tercentennial Fund of the Bank of Sweden (J2004-0511) and the European
Union (EU15636: TACT).
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J9 BIOL LETTERS
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PD JUN 23
PY 2010
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IS 3
BP 375
EP 378
DI 10.1098/rsbl.2009.0897
PG 4
WC Biology; Ecology; Evolutionary Biology
SC Life Sciences & Biomedicine - Other Topics; Environmental Sciences &
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GA 594SU
UT WOS:000277559000026
PM 20031980
ER
PT J
AU Zaki, J
Hennigan, K
Weber, J
Ochsner, KN
AF Zaki, Jamil
Hennigan, Kelly
Weber, Jochen
Ochsner, Kevin N.
TI Social Cognitive Conflict Resolution: Contributions of Domain-General
and Domain-Specific Neural Systems
SO JOURNAL OF NEUROSCIENCE
LA English
DT Article
ID AUTISM SPECTRUM DISORDERS; INFERIOR PREFRONTAL CORTEX; MEDIAL
FRONTAL-CORTEX; ANTERIOR CINGULATE; EMOTIONAL CONFLICT; EMPATHIC
ACCURACY; ASPERGER-SYNDROME; MIRROR; BRAIN; MIND
AB Cognitive control mechanisms allow individuals to behave adaptively in the face of complex and sometimes conflicting information. Although the neural bases of these control mechanisms have been examined in many contexts, almost no attention has been paid to their role in resolving conflicts between competing social cues, which is surprising given that cognitive conflicts are part of many social interactions. Evidence about the neural processing of social information suggests that two systems-the mirror neuron system (MNS) and mental state attribution system (MSAS)-are specialized for processing nonverbal and contextual social cues, respectively. This could support a model of social cognitive conflict resolution in which competition between social cues would recruit domain-general cognitive control mechanisms, which in turn would bias processing toward the MNS or MSAS. Such biasing could also alter social behaviors, such as inferences made about the internal states of others. We tested this model by scanning participants using functional magnetic resonance imaging while they drew inferences about the social targets' emotional states based on congruent or incongruent nonverbal and contextual social cues. Conflicts between social cues recruited the anterior cingulate and lateral prefrontal cortex, brain areas associated with domain-general control processes. This activation was accompanied by biasing of neural activity toward areas in the MNS or MSAS, which tracked, respectively, with perceivers' behavioral reliance on nonverbal or contextual cues when drawing inferences about targets' emotions. Together, these data provide evidence about both domain-general and domain-specific mechanisms involved in resolving social cognitive conflicts.
C1 [Zaki, Jamil; Weber, Jochen; Ochsner, Kevin N.] Columbia Univ, Dept Psychol, New York, NY 10027 USA.
[Hennigan, Kelly] Stanford Univ, Dept Psychol, Stanford, CA 94305 USA.
RP Zaki, J (reprint author), Columbia Univ, Dept Psychol, 1190 Amsterdam Ave, New York, NY 10027 USA.
EM jamil@psych.columbia.edu; ochsner@psych.columbia.edu
FU Autism Speaks Grant [4787]; National Institute on Drug Abuse [DA022541];
National Institutes of Health [MH076137]
FX This work was supported by Autism Speaks Grant 4787 (J.Z.), National
Institute on Drug Abuse Grant DA022541 (K.N.O.), and National Institutes
of Health Grant MH076137 (K.N.O.). We thank Marget Thomas and Annie
Knickman for assistance in data collection.
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NR 66
TC 48
Z9 48
PU SOC NEUROSCIENCE
PI WASHINGTON
PA 11 DUPONT CIRCLE, NW, STE 500, WASHINGTON, DC 20036 USA
SN 0270-6474
J9 J NEUROSCI
JI J. Neurosci.
PD JUN 23
PY 2010
VL 30
IS 25
BP 8481
EP 8488
DI 10.1523/JNEUROSCI.0382-10.2010
PG 8
WC Neurosciences
SC Neurosciences & Neurology
GA 614RH
UT WOS:000279076900014
PM 20573895
ER
PT J
AU Suvrathan, A
Hoeffer, CA
Wong, H
Klann, E
Chattarji, S
AF Suvrathan, Aparna
Hoeffer, Charles A.
Wong, Helen
Klann, Eric
Chattarji, Sumantra
TI Characterization and reversal of synaptic defects in the amygdala in a
mouse model of fragile X syndrome
SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF
AMERICA
LA English
DT Article
DE autism; long-term potentiation; synaptic plasticity; metabotropic
glutamate receptor
ID MENTAL-RETARDATION PROTEIN; LONG-TERM POTENTIATION; GLUTAMATE RECEPTORS;
MICE LACKING; FEAR MEMORY; PLASTICITY; FMR1; INTERNALIZATION;
IMPAIRMENT; DEFICIENCY
AB Fragile X syndrome (FXS), a common inherited form of mental impairment and autism, is caused by transcriptional silencing of the fragile X mental retardation 1 (FMR1) gene. Earlier studies have identified a role for aberrant synaptic plasticity mediated by the metabotropic glutamate receptors (mGluRs) in FXS. However, many of these observations are derived primarily from studies in the hippocampus. The strong emotional symptoms of FXS, on the other hand, are likely to involve the amygdala. Unfortunately, little is known about how exactly FXS affects synaptic function in the amygdala. Here, using whole-cell recordings in brain slices from adult Fmr1 knockout mice, we find mGluR-dependent long-term potentiation to be impaired at thalamic inputs to principal neurons in the lateral amygdala. Consistent with this long-term potentiation deficit, surface expression of the AMPA receptor subunit, GluR1, is reduced in the lateral amygdala of knockout mice. In addition to these postsynaptic deficits, lower presynaptic release was manifested by a decrease in the frequency of spontaneous miniature excitatory postsynaptic currents (mEPSCs), increased paired-pulse ratio, and slower use-dependent block of NMDA receptor currents. Strikingly, pharmacological inactivation of mGluR5 with 2-methyl-6-phenylethynyl-pyridine (MPEP) fails to rescue either the deficit in long-term potentiation or surface GluR1. However, the same acute MPEP treatment reverses the decrease in mEPSC frequency, a finding of potential therapeutic relevance. Therefore, our results suggest that synaptic defects in the amygdala of knockout mice are still amenable to pharmacological interventions against mGluR5, albeit in a manner not envisioned in the original hippocampal framework.
C1 [Suvrathan, Aparna; Chattarji, Sumantra] Natl Ctr Biol Sci, Bangalore 560065, Karnataka, India.
[Hoeffer, Charles A.; Wong, Helen; Klann, Eric] NYU, Ctr Neural Sci, New York, NY 10003 USA.
RP Chattarji, S (reprint author), Natl Ctr Biol Sci, Bangalore 560065, Karnataka, India.
EM shona@ncbs.res.in
FU FRAXA Research Foundation; Pfizer Asia; National Centre for Biological
Sciences, Bangalore
FX We thank Candice Carr, Bridget Dolan, Kathleen Oram, and others at the
Tonegawa and Bear laboratories (Picower Institute for Learning and
Memory, Massachusetts Institute of Technology, Cambridge, MA) for
genotyping and providing us the mice. This work was supported by funds
from the FRAXA Research Foundation, a Pfizer Asia R and D collaborative
grant, and the National Centre for Biological Sciences, Bangalore.
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NR 25
TC 65
Z9 66
PU NATL ACAD SCIENCES
PI WASHINGTON
PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA
SN 0027-8424
J9 P NATL ACAD SCI USA
JI Proc. Natl. Acad. Sci. U. S. A.
PD JUN 22
PY 2010
VL 107
IS 25
BP 11591
EP 11596
DI 10.1073/pnas.1002262107
PG 6
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 614KS
UT WOS:000279058000078
PM 20534533
ER
PT J
AU Delorme, R
Moreno-De-Luca, D
Gennetier, A
Maier, W
Chaste, P
Mossner, R
Grabe, HJ
Ruhrmann, S
Falkai, P
Mouren, MC
Leboyer, M
Wagner, M
Betancur, C
AF Delorme, Richard
Moreno-De-Luca, Daniel
Gennetier, Aurelie
Maier, Wolfgang
Chaste, Pauline
Moessner, Rainald
Grabe, Hans Joergen
Ruhrmann, Stephan
Falkai, Peter
Mouren, Marie-Christine
Leboyer, Marion
Wagner, Michael
Betancur, Catalina
TI Search for copy number variants in chromosomes 15q11-q13 and 22q11.2 in
obsessive compulsive disorder
SO BMC MEDICAL GENETICS
LA English
DT Article
ID PRADER-WILLI-SYNDROME; CARDIO-FACIAL SYNDROME; DEPENDENT PROBE
AMPLIFICATION; AUTISM SPECTRUM DISORDERS; MENTAL-RETARDATION; DELETION
SYNDROME; TOURETTE-SYNDROME; VELOCARDIOFACIAL SYNDROME; DUPLICATION
SYNDROME; PROXIMAL 15Q
AB Background: Obsessive-compulsive disorder (OCD) is a clinically and etiologically heterogeneous syndrome. The high frequency of obsessive-compulsive symptoms reported in subjects with the 22q11.2 deletion syndrome (DiGeorge/velocardiofacial syndrome) or Prader-Willi syndrome (15q11-13 deletion of the paternally derived chromosome), suggests that gene dosage effects in these chromosomal regions could increase risk for OCD. Therefore, the aim of this study was to search for microrearrangements in these two regions in OCD patients.
Methods: We screened the 15q11-13 and 22q11.2 chromosomal regions for genomic imbalances in 236 patients with OCD using multiplex ligation-dependent probe amplification (MLPA).
Results: No deletions or duplications involving 15q11-13 or 22q11.2 were identified in our patients.
Conclusions: Our results suggest that deletions/duplications of chromosomes 15q11-13 and 22q11.2 are rare in OCD. Despite the negative findings in these two regions, the search for copy number variants in OCD using genome-wide array-based methods is a highly promising approach to identify genes of etiologic importance in the development of OCD.
C1 [Moreno-De-Luca, Daniel; Gennetier, Aurelie; Betancur, Catalina] INSERM, U952, Paris, France.
[Delorme, Richard; Chaste, Pauline; Leboyer, Marion] Inst Mondor Rech Biomed, INSERM, Creteil, France.
[Delorme, Richard; Chaste, Pauline; Mouren, Marie-Christine] Hop Robert Debre, AP HP, Dept Child & Adolescent Psychiat, F-75019 Paris, France.
[Moreno-De-Luca, Daniel; Gennetier, Aurelie; Betancur, Catalina] CNRS, UMR 7224, Paris, France.
[Moreno-De-Luca, Daniel; Gennetier, Aurelie; Betancur, Catalina] Univ Paris 06, Paris, France.
[Maier, Wolfgang; Moessner, Rainald; Wagner, Michael] Univ Bonn, Dept Psychiat & Psychotherapy, D-5300 Bonn, Germany.
[Grabe, Hans Joergen] Ernst Moritz Arndt Univ Greifswald, Dept Psychiat & Psychotherapy, Stralsund, Germany.
[Ruhrmann, Stephan] Univ Cologne, Dept Psychiat & Psychotherapy, Cologne, Germany.
[Falkai, Peter] Univ Gottingen, Dept Psychiat & Psychotherapy, Gottingen, Germany.
[Leboyer, Marion] Henri Mondor Albert Chenevier Hosp, AP HP, Dept Psychiat, Creteil, France.
[Leboyer, Marion] Univ Paris 12, Fac Med, Creteil, France.
RP Betancur, C (reprint author), INSERM, U952, Paris, France.
EM catalina.betancur@inserm.fr
RI Wagner, Michael/E-2325-2011; Ruhrmann, Stephan/F-1461-2013
OI Ruhrmann, Stephan/0000-0002-6022-2364
FU INSERM; Fondation de France; FondaMental Foundation; German Research
Foundation (DFG)
FX We are grateful to the patients and their families who made this
research possible. We thank the Centre d'Investigations Cliniques of the
Robert Debre hospital (Prof. Jacz-Aigrain) and the cell bank of the
Cochin hospital (Prof. Delpech) for their technical assistance in the
blood sampling and cell line immortalization of the French families.
Drs. F. Rampacher, S. Schulze-Rauschenbach, S. Ettelt, K. Meyer, S.
Kraft, C. Reck, A. Vogeley are acknowledged for the clinical assessment
of the German patients, and V. Guttenthaler and C. Hanses for expert
technical assistance provided to the German research group. This
research was supported by INSERM, Fondation de France, FondaMental
Foundation, and the German Research Foundation (DFG).
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NR 42
TC 5
Z9 5
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1471-2350
J9 BMC MED GENET
JI BMC Med. Genet.
PD JUN 21
PY 2010
VL 11
AR 100
DI 10.1186/1471-2350-11-100
PG 6
WC Genetics & Heredity
SC Genetics & Heredity
GA 637ND
UT WOS:000280824100001
PM 20565924
ER
PT J
AU Dorey, E
AF Dorey, Emma
TI Diagnostics Hope for genetic test for autism
SO CHEMISTRY & INDUSTRY
LA English
DT News Item
NR 0
TC 0
Z9 0
PU SOC CHEMICAL INDUSTRY
PI LONDON
PA 14 BELGRAVE SQUARE, LONDON SW1X 8PS, ENGLAND
SN 0009-3068
J9 CHEM IND-LONDON
JI Chem. Ind.
PD JUN 21
PY 2010
IS 12
BP 9
EP 9
PG 1
WC Chemistry, Applied
SC Chemistry
GA 616LB
UT WOS:000279209800012
ER
PT J
AU Spence, SJ
Thurm, A
AF Spence, Sarah J.
Thurm, Audrey
TI Testing autism interventions: trials and tribulations
SO LANCET
LA English
DT Editorial Material
ID SPECTRUM DISORDERS; CHILDREN
C1 [Spence, Sarah J.; Thurm, Audrey] NIMH, Pediat & Behav Neurosci Branch, Intramural Res Program, NIH, Bethesda, MD 20892 USA.
RP Spence, SJ (reprint author), NIMH, Pediat & Behav Neurosci Branch, Intramural Res Program, NIH, Bethesda, MD 20892 USA.
EM spences2@mail.nih.gov
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NR 10
TC 10
Z9 10
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0140-6736
J9 LANCET
JI Lancet
PD JUN 19
PY 2010
VL 375
IS 9732
BP 2124
EP 2125
DI 10.1016/S0140-6736(10)60757-X
PG 2
WC Medicine, General & Internal
SC General & Internal Medicine
GA 617BF
UT WOS:000279255100005
PM 20494435
ER
PT J
AU Green, J
Charman, T
McConachie, H
Aldred, C
Slonims, V
Howlin, P
Le Couteur, A
Leadbitter, K
Hudry, K
Byford, S
Barrett, B
Temple, K
Macdonald, W
Pickles, A
AF Green, Jonathan
Charman, Tony
McConachie, Helen
Aldred, Catherine
Slonims, Vicky
Howlin, Pat
Le Couteur, Ann
Leadbitter, Kathy
Hudry, Kristelle
Byford, Sarah
Barrett, Barbara
Temple, Kathryn
Macdonald, Wendy
Pickles, Andrew
CA PACT Consortium
TI Parent-mediated communication-focused treatment in children with autism
(PACT): a randomised controlled trial
SO LANCET
LA English
DT Article
ID SPECTRUM DISORDERS; JOINT ATTENTION; YOUNG-CHILDREN; INTERVENTION;
LANGUAGE; BEHAVIORS; EFFICACY; PLAY
AB Background Results of small trials suggest that early interventions for social communication are effective for the treatment of autism in children. We therefore investigated the efficacy of such an intervention in a larger trial.
Methods Children with core autism (aged 2 years to 4 years and 11 months) were randomly assigned in a one-to-one ratio to a parent-mediated communication-focused (Preschool Autism Communication Trial [PACT]) intervention or treatment as usual at three specialist centres in the UK. Those assigned to PACT were also given treatment as usual. Randomisation was by use of minimisation of probability in the marginal distribution of treatment centre, age (<= 42 months or >42 months), and autism severity (Autism Diagnostic Observation Schedule-Generic [ADOS-G] algorithm score 12-17 or 18-24). Primary outcome was severity of autism symptoms (a total score of social communication algorithm items from ADOS-G, higher score indicating greater severity) at 13 months. Complementary secondary outcomes were measures of parent-child interaction, child language, and adaptive functioning in school. Analysis was by intention to treat. This study is registered as an International Standard Randomised Controlled Trial, number ISRCTN58133827.
Results 152 children were recruited. 77 were assigned to PACT (London [n=26], Manchester [n=26], and Newcastle [n=25]); and 75 to treatment as usual (London [n=26], Manchester [n=26], and Newcastle [n=23]). At the 13-month endpoint, the severity of symptoms was reduced by 3.9 points (SD 4.7) on the ADOS-G algorithm in the group assigned to PACT, and 2.9 (3.9) in the group assigned to treatment as usual, representing a between-group effect size of 0.24 (95% CI 0.59 to 0.11), after adjustment for centre, sex, socioeconomic status, age, and verbal and nonverbal abilities. Treatment effect was positive for parental synchronous response to child (1.22, 0.85 to 1.59), child initiations with parent (0.41, 0.08 to 0.74), and for parent-child shared attention (0.33, 0.02 to 0.68). Effects on directly assessed language and adaptive functioning in school were small.
Interpretation On the basis of our findings, we cannot recommend the addition of the PACT intervention to treatment as usual for the reduction of autism symptoms; however, a clear benefit was noted for parent-child dyadic social communication.
C1 [Green, Jonathan; Aldred, Catherine; Leadbitter, Kathy] Univ Manchester, Psychiat Res Grp, Manchester, Lancs, England.
[Pickles, Andrew] Univ Manchester, Hlth Sci Res Grp, Manchester, Lancs, England.
[Macdonald, Wendy] Univ Manchester, Natl Inst Hlth Res, Sch Primary Care Res, Manchester, Lancs, England.
[Green, Jonathan] Royal Manchester Childrens Hosp, Manchester M27 1HA, Lancs, England.
[Green, Jonathan] Manchester Biomed Res Ctr, Manchester, Lancs, England.
[Charman, Tony; Hudry, Kristelle] Univ London, Inst Educ, Ctr Res Autism & Educ, London WC1N 1AZ, England.
[McConachie, Helen; Le Couteur, Ann; Temple, Kathryn] Newcastle Univ, Inst Hlth & Soc, Newcastle Upon Tyne, Tyne & Wear, England.
[Aldred, Catherine] Stockport Primary Care Trust, Childrens Therapy Serv, Stockport, Lancs, England.
[Slonims, Vicky] Guys & St Thomas NHS Fdn Trust, Newcomen Ctr, London, England.
[Howlin, Pat] Kings Coll London, Inst Psychiat, Dept Clin Psychol, London WC2R 2LS, England.
[Byford, Sarah; Barrett, Barbara] Kings Coll London, Ctr Econ Mental Hlth, London WC2R 2LS, England.
RP Green, J (reprint author), Room 4-319,Univ Pl,Oxford Rd, Manchester M13 9PL, Lancs, England.
EM jonathan.green@manchester.ac.uk
RI Howlin, Patricia/A-7622-2011; Pickles, Andrew/A-9625-2011; Barrett,
Barbara/F-7606-2010; Byford, Sarah/D-1699-2010; Charman,
Tony/A-2085-2014
OI Pickles, Andrew/0000-0003-1283-0346; Barrett,
Barbara/0000-0002-0270-6256; Byford, Sarah/0000-0001-7084-1495; Charman,
Tony/0000-0003-1993-6549
FU UK Medical Research Council; UK Department for Children, Schools and
Families; University of Manchester; Medical Research Council [G0401546];
UK Department of Health; UK National Autistic Society; UK Mental Health
Research Network
FX This study was sponsored by the University of Manchester. PACT was
funded by the Medical Research Council (G0401546), the UK Department for
Children, Schools and Families; with a UK Department of Health award for
excess treatment and support costs. We gratefully thank all families
participating in the study and the referring professionals. We
acknowledge invaluable support and guidance from our trial steering
committee (Eric Taylor, Alan Emond, Francis Creed, Richard Mills, and
Tina McClelland), and our data monitoring and ethics committee (Patrick
Bolton, Paula Williamson, and Brain Neville). Other support for trial
design and management was provided by Barbara Farrell, and Richard
Mills. We are grateful for the support and collaboartion of the UK
National Autistic Society throughout the trial. The study was adopted by
the UK Mental Health Research Network, who provided valuable officer
support clinical studies. UK Medical Research Council.
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NR 32
TC 115
Z9 116
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0140-6736
J9 LANCET
JI Lancet
PD JUN 19
PY 2010
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IS 9732
BP 2152
EP 2160
DI 10.1016/S0140-6736(10)60587-9
PG 9
WC Medicine, General & Internal
SC General & Internal Medicine
GA 617BF
UT WOS:000279255100025
PM 20494434
ER
PT J
AU Iacoangeli, A
Bianchi, R
Tiedge, H
AF Iacoangeli, Anna
Bianchi, Riccardo
Tiedge, Henri
TI Regulatory RNAs in brain function and disorders
SO BRAIN RESEARCH
LA English
DT Review
DE Regulatory RNA; Non-protein-coding RNA; Neurons; Brain disorders
ID PRADER-WILLI-SYNDROME; DENDRITIC BC1 RNA; METABOTROPIC GLUTAMATE
RECEPTORS; AUTISM SPECTRUM DISORDERS; SMALL NUCLEOLAR RNAS;
PROTEIN-KINASE DMPK; NONCODING RNAS; MYOTONIC-DYSTROPHY; MESSENGER-RNA;
ANGELMAN-SYNDROME
AB Regulatory RNAs are being increasingly investigated in neurons, and important roles in brain function have been revealed. Regulatory RNAs are non-protein-coding RNAs (npcRNAs) that comprise a heterogeneous group of molecules, varying in size and mechanism of action. Regulatory RNAs often exert post-transcriptional control of gene expression, resulting in gene silencing or gene expression stimulation. Here, we review evidence that regulatory RNAs are implicated in neuronal development, differentiation, and plasticity. We will also discuss npcRNA dysregulation that may be involved in pathological states of the brain such as neurodevelopmental disorders, neurodegeneration, and epilepsy. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Iacoangeli, Anna; Bianchi, Riccardo; Tiedge, Henri] SUNY Hlth Sci Ctr, Dept Physiol & Pharmacol, Robert F Furchgott Ctr Neural & Behav Sci, Brooklyn, NY 11203 USA.
[Bianchi, Riccardo; Tiedge, Henri] SUNY Hlth Sci Ctr, Program Neural & Behav Sci, Brooklyn, NY 11203 USA.
RP Tiedge, H (reprint author), SUNY Hlth Sci Ctr, Dept Physiol & Pharmacol, Robert F Furchgott Ctr Neural & Behav Sci, 450 Clarkson Ave, Brooklyn, NY 11203 USA.
EM henri.tiedge@downstate.edu
FU SUNY Downstate [1057697]; FRAXA Research Foundation; National Institutes
of Health [NS046769, DA026110]
FX Work in the author's laboratories has been supported by SUNY Downstate
grant 1057697 to RB, by a FRAXA Research Foundation grant to HT, and by
National Institutes of Health grants NS046769 and DA026110 to HT.
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NR 175
TC 7
Z9 7
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0006-8993
J9 BRAIN RES
JI Brain Res.
PD JUN 18
PY 2010
VL 1338
SI SI
BP 36
EP 47
DI 10.1016/j.brainres.2010.03.042
PG 12
WC Neurosciences
SC Neurosciences & Neurology
GA 614YW
UT WOS:000279096700005
PM 20307503
ER
PT J
AU Xu, B
Karayiorgou, M
Gogos, JA
AF Xu, Bin
Karayiorgou, Maria
Gogos, Joseph A.
TI MicroRNAs in psychiatric and neurodevelopmental disorders
SO BRAIN RESEARCH
LA English
DT Review
DE MicroRNA; Psychiatric disorder; Schizophrenia; Chromosome 22q11.2;
Mental retardation; Autism; Neurodevelopment; Synaptic plasticity
ID FRAGILE-X-SYNDROME; MENTAL-RETARDATION PROTEIN; 22Q11.2 DELETION
SYNDROME; AUTISM SPECTRUM DISORDER; RETT-SYNDROME; TOURETTE-SYNDROME;
DOWN-SYNDROME; POSTTRANSCRIPTIONAL REGULATION; NEURONAL DIFFERENTIATION;
SYNAPTIC PLASTICITY
AB Abnormalities in microRNA (miRNA)-mediated gene regulation have been observed in a variety of human diseases, especially in cancer. Here, we provide an account of newly emerging connections between miRNAs with various psychiatric and neurodevelopmental disorders, including recent findings of miRNA dysregulation in the 22q11.2 microdeletion syndrome, a well-established genetic risk factor for schizophrenia. miRNAs appear to be components of both the genetic architecture of these complex phenotypes as well as integral parts of the biological pathways that mediate the effects of primary genetic deficits. Therefore, they may contribute to both genetic heterogeneity and phenotypic variation of psychiatric and neurodevelopmental disorders and could serve as novel therapeutic targets. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Gogos, Joseph A.] Columbia Univ, Med Ctr, Dept Physiol & Cellular Biophys, New York, NY 10032 USA.
[Xu, Bin; Karayiorgou, Maria] Columbia Univ, Dept Psychiat, New York, NY 10032 USA.
[Gogos, Joseph A.] Columbia Univ, Dept Neurosci, New York, NY 10032 USA.
RP Gogos, JA (reprint author), Columbia Univ, Med Ctr, Dept Physiol & Cellular Biophys, 630 W 168th St,P&S 11-519, New York, NY 10032 USA.
EM jag90@columbia.edu
FU NIMH; McKnight Foundation; March of Dimes; Lieber Center for
Schizophrenia Research; Simons Foundation; NARSAD
FX Work in the authors' laboratory is supported by grants from NIMH,
McKnight Foundation, March of Dimes, Lieber Center for Schizophrenia
Research, Simons Foundation and NARSAD. We thank P. A. Arguello and R.
Levy for critical reading of the manuscript.
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NR 124
TC 32
Z9 35
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0006-8993
J9 BRAIN RES
JI Brain Res.
PD JUN 18
PY 2010
VL 1338
SI SI
BP 78
EP 88
DI 10.1016/j.brainres.2010.03.109
PG 11
WC Neurosciences
SC Neurosciences & Neurology
GA 614YW
UT WOS:000279096700009
PM 20388499
ER
PT J
AU Miller, BH
Wahlestedt, C
AF Miller, Brooke H.
Wahlestedt, Claes
TI MicroRNA dysregulation in psychiatric disease
SO BRAIN RESEARCH
LA English
DT Review
DE MicroRNA; Schizophrenia; Bipolar disorder; NMDA; miR-132
ID GENOME-WIDE ASSOCIATION; COMORBIDITY SURVEY REPLICATION; DSM-IV
DISORDERS; BIPOLAR DISORDER; POSTTRANSCRIPTIONAL REGULATION; SYNAPTIC
PLASTICITY; GENETIC ASSOCIATION; MENTAL-RETARDATION; PREFRONTAL CORTEX;
PROTEIN-SYNTHESIS
AB MicroRNAs (miRNAs) are small regulatory RNAs that individually regulate up to several hundred genes, and collectively may regulate as much as two-thirds of the transcriptome. Recent evidence supports a role for miRNA dysregulation in psychiatric and neurological disorders, including schizophrenia, bipolar disorder, and autism. Small changes in miRNA expression can fine-tune the expression of multiple genes within a biological network, suggesting that miRNA dysregulation may underlie many of the molecular changes observed in psychiatric disease, and that therapeutic regulation of miRNA levels may represent a novel treatment option. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Miller, Brooke H.; Wahlestedt, Claes] Scripps Florida, Dept Neurosci, Jupiter, FL 33458 USA.
RP Wahlestedt, C (reprint author), Scripps Florida, Dept Neurosci, Jupiter, FL 33458 USA.
EM clawah@scripps.edu
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NR 113
TC 56
Z9 60
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0006-8993
J9 BRAIN RES
JI Brain Res.
PD JUN 18
PY 2010
VL 1338
SI SI
BP 89
EP 99
DI 10.1016/j.brainres.2010.03.035
PG 11
WC Neurosciences
SC Neurosciences & Neurology
GA 614YW
UT WOS:000279096700010
PM 20303342
ER
PT J
AU De Smaele, E
Ferretti, E
Gulino, A
AF De Smaele, Enrico
Ferretti, Elisabetta
Gulino, Alberto
TI MicroRNAs as biomarkers for CNS cancer and other disorders
SO BRAIN RESEARCH
LA English
DT Review
DE miRNA; Neurodegeneration; Tumors; Medulloblastoma; Glioma
ID CENTRAL-NERVOUS-SYSTEM; TUMOR STEM-CELLS; ALZHEIMERS-DISEASE; EXPRESSION
PROFILES; HUNTINGTONS-DISEASE; HETEROGENEOUS DYSREGULATION; PLASMA
MICRORNAS; AUTISM SPECTRUM; GENE-EXPRESSION; DOWN-REGULATION
AB The use of miRNAs as biomarkers has gained growing interest in the last few years. Their role in regulating a great variety of targets and, as a consequence, multiple pathways, makes their use in diagnostics a powerful tool to be exploited for early detection of disease, risk assessment and prognosis and for the design of innovative therapeutic strategies. While still not fully validated, profiling of blood cells, exosomes or body fluid miRNAs would represent a tremendous and promising advance in non-invasive diagnostics of CNS disorders. A major challenge is represented by technological aspects of miRNA detection and discovery aiming to genome-wide high throughput, sensitive and accurate analysis.
Although there is much to be learned in the field, this review will highlight the potential role of miRNA as a new class of biomarkers in several CNS disorders, including neurodegenerative diseases such as Alzheimer, Huntington and Parkinson diseases, schizophrenia and autism as well as different types of cancer (e.g. gliomas and medulloblastomas). (C) 2010 Elsevier B.V. All rights reserved.
C1 [De Smaele, Enrico; Ferretti, Elisabetta; Gulino, Alberto] Univ Roma La Sapienza, Dept Expt Med, I-00161 Rome, Italy.
[Gulino, Alberto] Neuromed Inst, Pozzilli, Italy.
RP Gulino, A (reprint author), Univ Roma La Sapienza, Dept Expt Med, 324 Viale Regina Elena, I-00161 Rome, Italy.
EM alberto.gulino@uniroma1.it
RI De Smaele, Enrico/C-1124-2013; ferretti, elisabetta/G-5413-2013
OI De Smaele, Enrico/0000-0003-4524-4423; ferretti,
elisabetta/0000-0001-7265-6429
FU Telethon [GGP07118]; Associazione Italiana per la Ricerca sul Cancro;
Italian Ministry of University and Research (FIRB, PRIN); Italian
Ministry of Health; Mariani Foundation; Roma Foundation; Pasteur
Institute, Cenci Bolognetti Foundation
FX We apologize to all scientists whose work could not be cited due to
space constraints. The authors are supported by Telethon Grant GGP07118,
Associazione Italiana per la Ricerca sul Cancro, the Italian Ministry of
University and Research (FIRB, PRIN), the Italian Ministry of Health,
Mariani Foundation, Roma Foundation and the Pasteur Institute, Cenci
Bolognetti Foundation.
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NR 117
TC 53
Z9 54
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0006-8993
J9 BRAIN RES
JI Brain Res.
PD JUN 18
PY 2010
VL 1338
SI SI
BP 100
EP 111
DI 10.1016/j.brainres.2010.03.103
PG 12
WC Neurosciences
SC Neurosciences & Neurology
GA 614YW
UT WOS:000279096700011
PM 20380821
ER
PT J
AU Apicella, CL
Cesarini, D
Johannesson, M
Dawes, CT
Lichtenstein, P
Wallace, B
Beauchamp, J
Westberg, L
AF Apicella, Coren L.
Cesarini, David
Johannesson, Magnus
Dawes, Christopher T.
Lichtenstein, Paul
Wallace, Bjoern
Beauchamp, Jonathan
Westberg, Lars
TI No Association between Oxytocin Receptor (OXTR) Gene Polymorphisms and
Experimentally Elicited Social Preferences
SO PLOS ONE
LA English
DT Article
ID GENOME-WIDE; AUTISM LOCI; HUMANS; BEHAVIOR; TRUST; REPLICATION;
DISORDERS; DEFICITS; SEARCH; GAME
AB Background: Oxytocin (OXT) has been implicated in a suite of complex social behaviors including observed choices in economic laboratory experiments. However, actual studies of associations between oxytocin receptor (OXTR) gene variants and experimentally elicited social preferences are rare.
Methodology/Principal Findings: We test hypotheses of associations between social preferences, as measured by behavior in two economic games, and 9 single nucleotide polymorphisms (SNPs) of the OXTR gene in a sample of Swedish twins (n = 684). Two standard economic games, the dictator game and the trust game, both involving real monetary consequences, were used to elicit such preferences. After correction for multiple hypothesis testing, we found no significant associations between any of the 9 single nucleotide polymorphisms (SNPs) and behavior in either of the games.
Conclusion: We were unable to replicate the most significant association reported in previous research between the amount donated in a dictator game and an OXTR genetic variant.
C1 [Apicella, Coren L.] Harvard Univ, Sch Med, Dept Hlth Care Policy, Boston, MA 02115 USA.
[Apicella, Coren L.] Harvard Univ, Dept Human Evolutionary Biol, Boston, MA 02115 USA.
[Cesarini, David] MIT, Dept Econ, Cambridge, MA 02139 USA.
[Dawes, Christopher T.] Univ Calif San Diego, Dept Polit Sci, La Jolla, CA 92093 USA.
[Johannesson, Magnus; Wallace, Bjoern] Stockholm Sch Econ, Dept Econ, S-11383 Stockholm, Sweden.
[Lichtenstein, Paul] Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden.
[Beauchamp, Jonathan] Harvard Univ, Dept Econ, Boston, MA 02115 USA.
[Westberg, Lars] Univ Gothenburg, Dept Pharmacol, Inst Neurosci & Physiol, Gothenburg, Sweden.
RP Apicella, CL (reprint author), Harvard Univ, Sch Med, Dept Hlth Care Policy, Boston, MA 02115 USA.
EM apicella@fas.harvard.edu
RI Johannesson, Magnus/E-9680-2011
OI Johannesson, Magnus/0000-0001-8759-6393
FU Swedish Resarch Council; Jan Wallander and Tom Hedelius Foundation;
Swedish Research Council; Swedish Council; Ministry for Higher Education
FX LW thanks Fredrik och Ingrid Thuringsstiftelse, Ake Wibergsstiftelse,
Ahlen-Stiftelsen, Jeanssons-stiftelsen, Magnus Bergvalls stiftelse,
Soderstrom-Konigska stiftelsen, Marta Lundqvist stiftelse and the
Swedish Resarch Council for financial support. MJ thanks the Jan
Wallander and Tom Hedelius Foundation, the Swedish Research Council, and
the Swedish Council for Working Life and Social Research for financial
support. The Swedish Twin Registry is supported by grants from the
Swedish Research Council and the The Ministry for Higher Education. The
funders had no role in study design, data collection and analysis,
decision to publish, or preparation of the manuscript.
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NR 49
TC 43
Z9 43
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JUN 16
PY 2010
VL 5
IS 6
AR e11153
DI 10.1371/journal.pone.0011153
PG 8
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 612GZ
UT WOS:000278886100017
PM 20585395
ER
PT J
AU Neville, T
AF Neville, Tina
TI Cutting-Edge Therapies for Autism 2010-2011
SO LIBRARY JOURNAL
LA English
DT Book Review
C1 [Neville, Tina] Univ S Carolina, St Petersburg Lib, Columbia, SC 29208 USA.
RP Neville, T (reprint author), Univ S Carolina, St Petersburg Lib, Columbia, SC 29208 USA.
CR SIRI K, 2010, CUTTINGEDGE THERAPIE
NR 1
TC 0
Z9 0
PU REED BUSINESS INFORMATION
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010 USA
SN 0363-0277
J9 LIBR J
JI Libr. J.
PD JUN 15
PY 2010
VL 135
IS 11
BP 86
EP 87
PG 2
WC Information Science & Library Science
SC Information Science & Library Science
GA 612KG
UT WOS:000278896600256
ER
PT J
AU Young, DM
Schenk, AK
Yang, SB
Jan, YN
Jan, LY
AF Young, David M.
Schenk, A. Katrin
Yang, Shi-Bing
Jan, Yuh Nung
Jan, Lily Yeh
TI Altered ultrasonic vocalizations in a tuberous sclerosis mouse model of
autism
SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF
AMERICA
LA English
DT Article
DE USV; TSC; mTOR; maternal care; social communication
ID KNOCKOUT MICE; BEHAVIOR; COMPLEX; COMMUNICATION; CHILDREN; DEFICITS;
INFANT; RATS
AB Tuberous sclerosis (TSC) is an autosomally dominant neurocutaneous disease notable for its high comorbidity with autism in human patients. Studies of murine models of tuberous sclerosis have found defects in cognition and learning, but thus far have not uncovered deficits in social behaviors relevant to autism. To explore social communication and interaction in TSC2 heterozygous mice, we recorded ultrasonic vocalizations (USV) and found that although both wild-type (WT) and heterozygous pups born to WT dams showed similar call rates and patterns, baseline vocalization rates were elevated in pups born to heterozygous dams. Further analysis revealed several robust features of maternal potentiation in all but WT pups born to heterozygous dams. This lack of potentiation is suggestive of defects in mother-pup social interaction during or before the reunion period between WT pups and heterozygous dams. Intriguingly, male pups of both genotypes born to heterozygous dams showed particularly heightened call rates and burst patterns. Because our maternal retrieval experiments revealed that TSC2(+/-) dams exhibited improved defensive reactions against intruders and highly efficient pup retrieval performance, the alterations in their pups' USVs and maternal potentiation do not appear to result from poor maternal care. These findings suggest that a pup's interaction with its mother strongly influences the pup's vocal communication, revealing an intriguing dependence of this social behavior on TSC2 gene dosage of both parties involved. Our study of this murine model thus uncovers social abnormalities that arise from TSC haploinsufficiency and are suggestive of autism.
C1 [Young, David M.; Yang, Shi-Bing; Jan, Yuh Nung; Jan, Lily Yeh] Univ Calif San Francisco, Howard Hughes Med Inst, San Francisco, CA 94143 USA.
[Young, David M.; Yang, Shi-Bing; Jan, Yuh Nung; Jan, Lily Yeh] Univ Calif San Francisco, Dept Physiol, San Francisco, CA 94143 USA.
[Schenk, A. Katrin] Univ Calif San Francisco, Dept Psychiat, San Francisco, CA 94143 USA.
RP Jan, LY (reprint author), Univ Calif San Francisco, Howard Hughes Med Inst, San Francisco, CA 94143 USA.
EM Lily.Jan@ucsf.edu
FU National Institutes of Health [R37 MH 06334]
FX We thank S. Bonasera, E. Storm, E. Goulding, R. Liu, J. Rubenstein, B.
Cheyette, L. Tecott, and F. Huang for helpful conversations, code, and
support; N. Shao and M. Wu for guidance in maternal care experiments;
and A. Rowson-Baldwin and Y. Shu for excellent technical assistance.
This study was supported by National Institutes of Health Grant R37 MH
06334 (to L. Y. J.). Y. N. Jan and L. Y. Jan are Howard Hughes Medical
Institute investigators.
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NR 30
TC 49
Z9 52
PU NATL ACAD SCIENCES
PI WASHINGTON
PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA
SN 0027-8424
J9 P NATL ACAD SCI USA
JI Proc. Natl. Acad. Sci. U. S. A.
PD JUN 15
PY 2010
VL 107
IS 24
BP 11074
EP 11079
DI 10.1073/pnas.1005620107
PG 6
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 611IC
UT WOS:000278807400054
PM 20534473
ER
PT J
AU Chen, KY
Gracheva, EO
Yu, SC
Sheng, Q
Richmond, J
Featherstone, DE
AF Chen, Kaiyun
Gracheva, Elena O.
Yu, Szi-Chieh
Sheng, Qi
Richmond, Janet
Featherstone, David E.
TI Neurexin in Embryonic Drosophila Neuromuscular Junctions
SO PLOS ONE
LA English
DT Article
ID GLUTAMATE-RECEPTOR SUBUNIT; SYNAPTIC VESICLE EXOCYTOSIS;
ALPHA-LATROTOXIN RECEPTOR; AUTISM SPECTRUM DISORDER;
CENTRAL-NERVOUS-SYSTEM; CELL-SURFACE PROTEINS; CA2+ CHANNELS;
NEUROLIGINS; RELEASE; CASK
AB Background: Neurexin is a synaptic cell adhesion protein critical for synapse formation and function. Mutations in neurexin and neurexin-interacting proteins have been implicated in several neurological diseases. Previous studies have described Drosophila neurexin mutant phenotypes in third instar larvae and adults. However, the expression and function of Drosophila neurexin early in synapse development, when neurexin function is thought to be most important, has not been described.
Methodology/Principal Findings: We use a variety of techniques, including immunohistochemistry, electron microscopy, in situ hybridization, and electrophysiology, to characterize neurexin expression and phenotypes in embryonic Drosophila neuromuscular junctions (NMJs). Our results surprisingly suggest that neurexin in embryos is present both pre and postsynaptically. Presynaptic neurexin promotes presynaptic active zone formation and neurotransmitter release, but along with postsynaptic neurexin, also suppresses formation of ectopic glutamate receptor clusters. Interestingly, we find that loss of neurexin only affects receptors containing the subunit GluRIIA.
Conclusions/Significance: Our study extends previous results and provides important detail regarding the role of neurexin in Drosophila glutamate receptor abundance. The possibility that neurexin is present postsynaptically raises new hypotheses regarding neurexin function in synapses, and our results provide new insights into the role of neurexin in synapse development.
C1 [Chen, Kaiyun; Gracheva, Elena O.; Yu, Szi-Chieh; Sheng, Qi; Richmond, Janet; Featherstone, David E.] Univ Illinois, Chicago, IL 60680 USA.
RP Chen, KY (reprint author), Univ Illinois, Chicago, IL 60680 USA.
EM def@uic.edu
FU National Institutes of Health (NIH/NINDS)
FX This work was funded by grants from the National Institutes of Health
(NIH/NINDS) to D.E.F. and J.E.R. The funders had no role in study
design, data collection and analysis, decision to publish, or
preparation of the manuscript.
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NR 68
TC 20
Z9 20
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JUN 14
PY 2010
VL 5
IS 6
AR e11115
DI 10.1371/journal.pone.0011115
PG 15
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 610NX
UT WOS:000278741100026
PM 20559439
ER
PT J
AU Igwe, MN
Bakare, MO
Agomoh, AO
Onyeama, GM
Okonkwo, KO
AF Igwe, Monday N.
Bakare, Muideen O.
Agomoh, Ahamefule O.
Onyeama, Gabriel M.
Okonkwo, Kevin O.
TI Factors influencing knowledge about childhood autism among final year
undergraduate Medical, Nursing and Psychology students of University of
Nigeria, Enugu State, Nigeria
SO ITALIAN JOURNAL OF PEDIATRICS
LA English
DT Article
ID EPIDEMIOLOGY; PERSPECTIVES; PREVALENCE; DISORDERS; CHILDREN
AB Background: Knowledge and awareness about childhood autism is low among health care workers and the general populace in Nigeria. Poor knowledge about childhood autism among final year medical, nursing and psychology students who would form tomorrow's child health care professionals can compromise early recognition and interventions that are known to improve prognosis in childhood autism. Educational factors that could be influencing knowledge about childhood autism among these future health care professionals are unknown. This study assessed knowledge about childhood autism among final year undergraduate medical, nursing and psychology students in south-eastern Nigeria and determined the factors that could be influencing such knowledge.
Methods: One hundred final year undergraduate students were randomly selected from each of the Departments of Medicine, Nursing Science and Psychology respectively of University of Nigeria, Enugu State, Nigeria making a sample size of three hundred. A socio-demographic questionnaire and knowledge about childhood autism among health workers (KCAHW) questionnaire were administered to the students.
Results: The total mean score for the three groups of students on the KCAHW questionnaire was 10.67 +/- 3.73 out of a possible total score of 19, with medical, nursing and psychology students having total mean scores of 12.24 +/- 3.24, 10.76 +/- 3.50 and 9.01 +/- 3.76 respectively. The mean scores for the three groups showed statistically significant difference for domain 1 (p = 0.000), domain 3 (p = 0.029), domain 4 (p = 0.000) and total score (p = 0.000), with medical students more likely to recognise symptoms and signs of autism compared to nursing and psychology students. The mean score in domain 2 did not show statistically significant difference among the three groups (p = 0.769). The total score on the KCAHW questionnaire is positively correlated with the number of weeks of posting in psychiatry (r = 0.319, p = 0.000) and the number of weeks of posting in paediatrics (r = 0.372, p = 0.000). The total score is also positively correlated with the number of credit hours of lectures in psychiatry/abnormal psychology (r = 0.324, p = 0.000) and the number of credit hours of lectures in paediatrics (r = 0.372, p = 0.000). The field of study also influenced knowledge about childhood autism (p = 0.000).
Conclusion: Peculiar situation in this environment as signified by inadequate human resources needed in the area of clinical psychology training often times necessitates employing first degree graduates in psychology into clinical positions. This calls for additional exposure of the undergraduate psychology students to training curriculum aimed at improving their early recognition of symptoms of autism spectrum disorders in this environment.
C1 [Igwe, Monday N.; Onyeama, Gabriel M.; Okonkwo, Kevin O.] Univ Nigeria Teaching Hosp Enugu, Dept Psychol Med, Enugu, Nigeria.
[Bakare, Muideen O.; Agomoh, Ahamefule O.] Fed Neuropsychiat Hosp, Child & Adolescent Unit, New Haven, Enugu, Nigeria.
RP Igwe, MN (reprint author), Univ Nigeria Teaching Hosp Enugu, Dept Psychol Med, Enugu, Nigeria.
EM mondayigwe@yahoo.com
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NR 16
TC 3
Z9 3
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1720-8424
J9 ITAL J PEDIATR
JI Ital. J. Pediatr.
PD JUN 13
PY 2010
VL 36
AR 44
DI 10.1186/1824-7288-36-44
PG 7
WC Pediatrics
SC Pediatrics
GA 798SI
UT WOS:000293231600001
PM 20540799
ER
PT J
AU Geddes, L
AF Geddes, Linda
TI Early test could pick out kids at risk of autism
SO NEW SCIENTIST
LA English
DT News Item
NR 0
TC 0
Z9 0
PU REED BUSINESS INFORMATION LTD
PI SUTTON
PA QUADRANT HOUSE THE QUADRANT, SUTTON SM2 5AS, SURREY, ENGLAND
SN 0262-4079
J9 NEW SCI
JI New Sci.
PD JUN 12
PY 2010
VL 206
IS 2764
BP 9
EP 9
PG 1
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 610WL
UT WOS:000278769500006
ER
PT J
AU Terauchi, A
Johnson-Venkatesh, EM
Toth, AB
Javed, D
Sutton, MA
Umemori, H
AF Terauchi, Akiko
Johnson-Venkatesh, Erin M.
Toth, Anna B.
Javed, Danish
Sutton, Michael A.
Umemori, Hisashi
TI Distinct FGFs promote differentiation of excitatory and inhibitory
synapses
SO NATURE
LA English
DT Article
ID PRESYNAPTIC ORGANIZING MOLECULES; SYNAPTIC-TRANSMISSION; GROWTH-FACTOR;
BRAIN; INTERNEURONS; LOCALIZATION; EPILEPSY; FAMILY
AB The differential formation of excitatory (glutamate-mediated) and inhibitory(GABA-mediated) synapses is a critical step for the proper functioning of the brain. An imbalance in these synapses may lead to various neurological disorders such as autism, schizophrenia, Tourette's syndrome and epilepsy(1-4). Synapses are formed through communication between the appropriate synaptic partners(5-8). However, the molecular mechanisms that mediate the formation of specific synaptic types are not known. Here we show that two members of the fibroblast growth factor (FGF) family, FGF22 and FGF7, promote the organization of excitatory and inhibitory presynaptic terminals, respectively, as target-derived presynaptic organizers. FGF22 and FGF7 are expressed by CA3 pyramidal neurons in the hippocampus. The differentiation of excitatory or inhibitory nerve terminals on dendrites of CA3 pyramidal neurons is specifically impaired in mutants lacking FGF22 or FGF7. These presynaptic defects are rescued by postsynaptic expression of the appropriate FGF. FGF22-deficientmice are resistant to epileptic seizures, and FGF7-deficient mice are prone to them, as expected from the alterations in excitatory/inhibitory balance. Differential effects of FGF22 and FGF7 involve both their distinct synaptic localizations and their use of different signalling pathways. These results demonstrate that specific FGFs act as target-derived presynaptic organizers and help to organize specific presynaptic terminals in the mammalian brain.
C1 [Terauchi, Akiko; Johnson-Venkatesh, Erin M.; Toth, Anna B.; Javed, Danish; Sutton, Michael A.; Umemori, Hisashi] Univ Michigan, Sch Med, Mol & Behav Neurosci Inst, Ann Arbor, MI 48109 USA.
[Sutton, Michael A.] Univ Michigan, Sch Med, Dept Mol & Integrat Physiol, Ann Arbor, MI 48109 USA.
[Umemori, Hisashi] Univ Michigan, Sch Med, Dept Biol Chem, Ann Arbor, MI 48109 USA.
RP Umemori, H (reprint author), Univ Michigan, Sch Med, Mol & Behav Neurosci Inst, Ann Arbor, MI 48109 USA.
EM umemoh@umich.edu
RI Sutton, Michael/C-6264-2011
FU Ester A. & Joseph Klingenstein Fund; Edward Mallinckrodt Jr Foundation;
March of Dimes Foundation; Whitehall Foundation
FX We thank J. Sanes and M. Hortsch for critical comments on the
manuscript; M. Webb and P. Woodhams for the antibody Py; D. Sorenson for
help with electron microscopy; A. Murayama for plasmid construction; M.
De Freitas for help with histology; and M. Zhang for technical
assistance. This work was supported by the Ester A. & Joseph
Klingenstein Fund, the Edward Mallinckrodt Jr Foundation, the March of
Dimes Foundation and the Whitehall Foundation (H. U.).
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NR 25
TC 66
Z9 66
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0028-0836
J9 NATURE
JI Nature
PD JUN 10
PY 2010
VL 465
IS 7299
BP 783
EP U8
DI 10.1038/nature09041
PG 6
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 608AM
UT WOS:000278551800046
PM 20505669
ER
PT J
AU Kita, Y
Gunji, A
Sakihara, K
Inagaki, M
Kaga, M
Nakagawa, E
Hosokawa, T
AF Kita, Yosuke
Gunji, Atsuko
Sakihara, Kotoe
Inagaki, Masumi
Kaga, Makiko
Nakagawa, Eiji
Hosokawa, Toru
TI Scanning Strategies Do Not Modulate Face Identification: Eye-Tracking
and Near-Infrared Spectroscopy Study
SO PLOS ONE
LA English
DT Article
ID VISUAL SELF-RECOGNITION; PREFRONTAL CORTEX; OWN FACE; OXYGENATED
HEMOGLOBIN; EXTERNAL FEATURES; UNFAMILIAR FACES; AUTISM; CHILDREN; FMRI;
METAANALYSIS
AB Background: During face identification in humans, facial information is sampled (seeing) and handled (processing) in ways that are influenced by the kind of facial image type, such as a self-image or an image of another face. However, the relationship between seeing and information processing is seldom considered. In this study, we aimed to reveal this relationship using simultaneous eye-tracking measurements and near-infrared spectroscopy (NIRS) in face identification tasks.
Methodology/Principal Findings: 22 healthy adult subjects (8 males and 14 females) were shown facial morphing movies in which an initial facial image gradually changed into another facial image (that is, the subject's own face was changed to a familiar face). The fixation patterns on facial features were recorded, along with changes in oxyhemoglobin (oxyHb) levels in the frontal lobe, while the subjects identified several faces. In the self-face condition (self-face as the initial image), hemodynamic activity around the right inferior frontal gyrus (IFG) was significantly greater than in the familiar-face condition. On the other hand, the scanning strategy was similar in almost all conditions with more fixations on the eyes and nose than on other areas. Fixation time on the eye area did not correlate with changes in oxyHb levels, and none of the scanning strategy indices could estimate the hemodynamic changes.
Conclusions/Significance: We conclude that hemodynamic activity, i.e., the means of processing facial information, is not always modulated by the face-scanning strategy, i.e., the way of seeing, and that the right IFG plays important roles in both self-other facial discrimination and self-evaluation.
C1 [Kita, Yosuke; Hosokawa, Toru] Tohoku Univ, Grad Sch Educ, Sendai, Miyagi 980, Japan.
[Kita, Yosuke] Japan Soc Promot Sci, Tokyo, Japan.
[Kita, Yosuke; Gunji, Atsuko; Sakihara, Kotoe; Inagaki, Masumi; Kaga, Makiko] Natl Ctr Neurol & Psychiat, Natl Inst Mental Hlth, Dept Dev Disorders, Tokyo, Japan.
[Nakagawa, Eiji] Natl Ctr Hosp Neurol & Psychiat, Natl Ctr Neurol & Psychiat, Dept Child Neurol, Tokyo, Japan.
RP Kita, Y (reprint author), Tohoku Univ, Grad Sch Educ, Sendai, Miyagi 980, Japan.
EM kitay@ncnp.go.jp
RI Gunji, Atsuko/O-6323-2014
OI Gunji, Atsuko/0000-0001-8908-8739
FU Japan Society for the Promotion of Science (JSPS) [20-8503]; Ministry of
Education, Culture, Sports, Science and Technology, Japan (MEXT) [4002]
FX The study was supported in part by a Japan Society for the Promotion of
Science (JSPS) Grant-in-Aid for the JSPS research fellows (20-8503 to
YK) and a Ministry of Education, Culture, Sports, Science and
Technology, Japan (MEXT) Grant-in-Aid for Scientific Research on
Innovative Areas (4002 to Ryusuke Kakigi and MI). The funders had no
role in study design, data collection and analysis, decision to publish,
or preparation of the manuscript.
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NR 42
TC 7
Z9 7
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JUN 10
PY 2010
VL 5
IS 6
AR e11050
DI 10.1371/journal.pone.0011050
PG 10
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 608QA
UT WOS:000278599600011
PM 20548791
ER
PT J
AU Cruz-Martin, A
Crespo, M
Portera-Cailliau, C
AF Cruz-Martin, Alberto
Crespo, Michelle
Portera-Cailliau, Carlos
TI Delayed Stabilization of Dendritic Spines in Fragile X Mice
SO JOURNAL OF NEUROSCIENCE
LA English
DT Article
ID MENTAL-RETARDATION PROTEIN; LONG-TERM POTENTIATION; RAT BARREL CORTEX;
METABOTROPIC GLUTAMATE RECEPTORS; FMR1 KNOCKOUT MICE; MOUSE MODEL;
IN-VIVO; SYNAPTIC PLASTICITY; AMPA RECEPTOR; TRANSLATIONAL REGULATION
AB Fragile X syndrome (FXS) causes mental impairment and autism through transcriptional silencing of the Fmr1 gene, resulting in the loss of the RNA-binding protein fragile X mental retardation protein (FMRP). Cortical pyramidal neurons in affected individuals and Fmr1 knock-out (KO) mice have an increased density of dendritic spines. The mutant mice also show defects in synaptic and experience dependent circuit plasticity, which are known to be mediated in part by dendritic spine dynamics. We used in vivo time-lapse imaging with two-photon microscopy through cranial windows in male and female neonatal mice to test the hypothesis that dynamics of dendritic protrusions are altered in KO mice during early postnatal development. We find that layer 2/3 neurons from wild-type mice exhibit a rapid decrease in dendritic spine dynamics during the first 2 postnatal weeks, as immature filopodia are replaced by mushroom spines. In contrast, KO mice show a developmental delay in the downregulation of spine turnover and in the transition from immature to mature spine subtypes. Blockade of metabotropic glutamate receptor (mGluR) signaling, which reverses some adult phenotypes of KO mice, accentuated this immature protrusion phenotype in KO mice. Thus, absence of FMRP delays spine stabilization and dysregulated mGluR signaling in FXS may partially normalize this early synaptic defect.
C1 [Portera-Cailliau, Carlos] Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurol, Reed Neurol Res Ctr A145, Los Angeles, CA 90095 USA.
[Portera-Cailliau, Carlos] Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurobiol, Los Angeles, CA 90095 USA.
RP Portera-Cailliau, C (reprint author), Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurol, Reed Neurol Res Ctr A145, 710 Westwood Plaza, Los Angeles, CA 90095 USA.
EM cpcailliau@mednet.ucla.edu
FU National Institute of Child Health and Human Development-National
Institutes of Health (NIH) [5R01 HD054453]; Diversity Supplement;
University of California; NIH-National Institute of General Medical
Sciences; FRAXA; Dana Foundations; Fu-Hsing and Jyu-Yuan Chen Family
Foundation
FX This work was supported by National Institute of Child Health and Human
Development-National Institutes of Health (NIH) Grant 5R01 HD054453 (C.
P.-C.) and a Diversity Supplement (A. C.-M.), the University of
California President's Postdoctoral Fellowship Program (A. C.-M.),
Minority Access to Research Careers Undergraduate Student Training in
Academic Research NIH-National Institute of General Medical Sciences (M.
C.), and the FRAXA and Dana Foundations, as well as by the generous
support of The Fu-Hsing and Jyu-Yuan Chen Family Foundation. We thank
Tara Chowdhury and James Anstey for maintaining the Fmr1 KO colony and
genotyping the mice, Adrian Cheng for help with MATLAB, Mike Tranfaglia
(from FRAXA) for providing MPEP, Karel Svoboda and Tim O'Connor for the
spine analysis software, and William Greenough for providing the Fmr1 KO
mice. We are grateful to Felix Schweizer, Peyman Golshani, and members
of the Portera-Cailliau Laboratory, especially Ricardo Mostany, for
helpful discussions and feedback on this manuscript.
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NR 77
TC 78
Z9 80
PU SOC NEUROSCIENCE
PI WASHINGTON
PA 11 DUPONT CIRCLE, NW, STE 500, WASHINGTON, DC 20036 USA
SN 0270-6474
J9 J NEUROSCI
JI J. Neurosci.
PD JUN 9
PY 2010
VL 30
IS 23
BP 7793
EP 7803
DI 10.1523/JNEUROSCI.0577-10.2010
PG 11
WC Neurosciences
SC Neurosciences & Neurology
GA 608LY
UT WOS:000278586900006
PM 20534828
ER
PT J
AU Glessner, JT
Reilly, MP
Kim, CE
Takahashi, N
Albano, A
Hou, CP
Bradfield, JP
Zhang, HT
Sleiman, PMA
Flory, JH
Imielinski, M
Frackelton, EC
Chiavacci, R
Thomas, KA
Garris, M
Otieno, FG
Davidson, M
Weiser, M
Reichenberg, A
Davis, KL
Friedman, JI
Cappola, TP
Margulies, KB
Rader, DJ
Grant, SFA
Buxbaum, JD
Gur, RE
Hakonarson, H
AF Glessner, Joseph T.
Reilly, Muredach P.
Kim, Cecilia E.
Takahashi, Nagahide
Albano, Anthony
Hou, Cuiping
Bradfield, Jonathan P.
Zhang, Haitao
Sleiman, Patrick M. A.
Flory, James H.
Imielinski, Marcin
Frackelton, Edward C.
Chiavacci, Rosetta
Thomas, Kelly A.
Garris, Maria
Otieno, Frederick G.
Davidson, Michael
Weiser, Mark
Reichenberg, Abraham
Davis, Kenneth L.
Friedman, Joseph I.
Cappola, Thomas P.
Margulies, Kenneth B.
Rader, Daniel J.
Grant, Struan F. A.
Buxbaum, Joseph D.
Gur, Raquel E.
Hakonarson, Hakon
TI Strong synaptic transmission impact by copy number variations in
schizophrenia
SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF
AMERICA
LA English
DT Article
DE genetics; genomics; neurobiology
ID GENOME-WIDE ASSOCIATION; BIPOLAR AFFECTIVE-DISORDER; RARE STRUCTURAL
VARIANTS; MITOCHONDRIAL DYSFUNCTION; EUROPEAN-ANCESTRY; AUTISM; GENES;
BRAIN; MICRODELETIONS; IDENTIFICATION
AB Schizophrenia is a psychiatric disorder with onset in late adolescence and unclear etiology characterized by both positive and negative symptoms, as well as cognitive deficits. To identify copy number variations (CNVs) that increase the risk of schizophrenia, we performed a whole-genome CNV analysis on a cohort of 977 schizophrenia cases and 2,000 healthy adults of European ancestry who were genotyped with 1.7 million probes. Positive findings were evaluated in an independent cohort of 758 schizophrenia cases and 1,485 controls. The Gene Ontology synaptic transmission family of genes was notably enriched for CNVs in the cases (P = 1.5 x 10(-7)). Among these, CACNA1B and DOC2A, both calcium-signaling genes responsible for neuronal excitation, were deleted in 16 cases and duplicated in 10 cases, respectively. In addition, RET and RIT2, both ras-related genes important for neural crest development, were significantly affected by CNVs. RET deletion was exclusive to seven cases, and RIT2 deletions were overrepresented common variant CNVs in the schizophrenia cases. Our results suggest that novel variations involving the processes of synaptic transmission contribute to the genetic susceptibility of schizophrenia.
C1 [Glessner, Joseph T.; Kim, Cecilia E.; Albano, Anthony; Hou, Cuiping; Bradfield, Jonathan P.; Zhang, Haitao; Sleiman, Patrick M. A.; Flory, James H.; Imielinski, Marcin; Frackelton, Edward C.; Chiavacci, Rosetta; Thomas, Kelly A.; Garris, Maria; Otieno, Frederick G.; Grant, Struan F. A.; Hakonarson, Hakon] Childrens Hosp Philadelphia, Ctr Appl Genom, Philadelphia, PA 19104 USA.
[Reilly, Muredach P.; Cappola, Thomas P.; Margulies, Kenneth B.; Rader, Daniel J.] Univ Penn, Sch Med, Penn Cardiovasc Inst, Philadelphia, PA 19104 USA.
[Takahashi, Nagahide; Davis, Kenneth L.; Friedman, Joseph I.; Buxbaum, Joseph D.] Mt Sinai Sch Med, Conte Ctr Neurosci Mental Disorders, New York, NY 10029 USA.
[Takahashi, Nagahide; Davis, Kenneth L.; Friedman, Joseph I.; Buxbaum, Joseph D.] Mt Sinai Sch Med, Dept Psychiat, New York, NY 10029 USA.
[Davidson, Michael; Weiser, Mark] Chaim Sheba Med Ctr, IL-52621 Tel Hashomer, Israel.
[Reichenberg, Abraham] Kings Coll London, Mt Sinai & Inst Psychiat, London SE5 8AF, England.
[Grant, Struan F. A.; Hakonarson, Hakon] Childrens Hosp Philadelphia, Div Human Genet, Philadelphia, PA 19104 USA.
[Grant, Struan F. A.; Hakonarson, Hakon] Univ Penn, Sch Med, Dept Pediat, Philadelphia, PA 19104 USA.
[Gur, Raquel E.] Univ Penn, Dept Psychiat, Div Neuropsychiat, Schizophrenia Ctr, Philadelphia, PA 19104 USA.
RP Hakonarson, H (reprint author), Childrens Hosp Philadelphia, Ctr Appl Genom, Philadelphia, PA 19104 USA.
EM hakonarson@chop.edu
FU National Institute of Mental Health; National Alliance for Research on
Schizophrenia and Depression; CHOP; Cotswold Foundation; National
Institutes of Health [R21HL092379, R01HL0885775, R01AG17022]; National
Institute of Mental Health, Conte Center for Neuroscience of Mental
Disorders [MH066392]; [MH-64045]; [MH-60722]
FX We gratefully thank all of the schizophrenia patients who participated
in this study and all of the control subjects who donated blood samples
to CHOP and the UPenn for genetic research purposes. We thank the
technical staff at CHOP's Center for Applied Genomics for generating the
genotypes used in this study and the medical assistants, nurses, and
medical staff who recruited the study subjects. We thank Kai Wang for
development of PennCNV-Affy. We also thank S. Kristinsson, L. A.
Hermannsson, and A. Krisbjornsson for their software design and
contributions; Pablo V. Gejman and Daniel B. Mirel for their oversight
of the MGS project and for providing access to the data; and Jonathan
Sebat and Deborah L. Levy for their collaborative contributions. We
thank the MGS consortium investigators for making the genotype data
available. Support for MGS case: control was provided by funding from
the National Institute of Mental Health and the National Alliance for
Research on Schizophrenia and Depression. Genotyping of part of the
sample was supported by the Genetic Association Information Network, and
the Paul Michael Donovan Charitable Foundation, The genotyping of
samples was provided through the National Center for Research Resources
and performed by the Center for Genotyping and Analysis at the Broad
Institute of Harvard and MIT. The dataset used for the analyses
described in this manuscript was obtained from dbGaP at
http://www.ncbi.nlm.nih.gov/gap (dbGaP accession number
phs000021.v2.p1). Data were accessed based on an authorized data access
request by H. H. and S. F. A. G. The study was supported by an
Institutional Development Award to the Center for Applied Genomics from
CHOP (to H. H.) and a Research Development Award from the Cotswold
Foundation (to H. H. and S. F. A. G.). The schizophrenia case
recruitment at UPenn was supported by MH-64045 and MH-60722 (to R. E.
G.). The sample collection and genotyping for the control population
typed at CHOP was supported by the National Institutes of Health
[Research Grants R21HL092379, R01HL0885775, and R01AG17022 (to T. P. C.
and K. B. M.)]. The collection and genotyping of samples from Mount
Sinai and Sheba Hospital was partially supported by the National
Institute of Mental Health, Conte Center for Neuroscience of Mental
Disorders (Grant MH066392 to J.D.B.).
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NR 56
TC 76
Z9 78
PU NATL ACAD SCIENCES
PI WASHINGTON
PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA
SN 0027-8424
J9 P NATL ACAD SCI USA
JI Proc. Natl. Acad. Sci. U. S. A.
PD JUN 8
PY 2010
VL 107
IS 23
BP 10584
EP 10589
DI 10.1073/pnas.1000274107
PG 6
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 608AH
UT WOS:000278549300047
PM 20489179
ER
PT J
AU Takayanagi, Y
Fujita, E
Yu, ZL
Yamagata, T
Momoi, MY
Momoi, T
Onaka, T
AF Takayanagi, Yuki
Fujita, Eriko
Yu, Zhiling
Yamagata, Takanori
Momoi, Mariko Y.
Momoi, Takashi
Onaka, Tatsushi
TI Impairment of social and emotional behaviors in Cadm1-knockout mice
SO BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
LA English
DT Article
DE Cell adhesion molecule 1 (CADM1); Social behavior; Anxiety-related
behavior; Motor function; Autism
ID AUTISM SPECTRUM DISORDER; CELL-ADHESION MOLECULE; IMMUNOGLOBULIN
SUPERFAMILY; OXYTOCIN; CHILDREN; MOUSE; GENE; ADOLESCENTS; DEFICITS;
LACKING
AB Cell adhesion molecule 1 (CADM1), a member of the immunoglobulin superfamily, mediates synaptic cell adhesion. Missense mutations in the CADM1 gene have been identified in autism spectrum disorder (ASD) patients. In the present study, we examined emotional behaviors, social behaviors and motor performances in Cadm1-knockout (KO) mice. Cadm1-KO mice showed increased anxiety-related behavior in open-field and light-dark transition tests. Social behaviors of Cadm1-KO mice were impaired in social interaction, resident-intruder and social memory/recognition tests. Furthermore, motor coordination and gait of Cadm1-MO mice were impaired in rotarod and footprint tests. Our study demonstrates that CADM1 plays roles in regulating emotional behaviors, social behaviors and motor performances, and that CADM1 has important implications for psychiatric disorders with disruptions in social behavior, such as autism. (C) 2010 Elsevier Inc. All rights reserved.
C1 [Onaka, Tatsushi] Jichi Med Univ, Div Brain & Neurophysiol, Dept Physiol, Shimotsuke, Tochigi 3290498, Japan.
[Fujita, Eriko; Momoi, Takashi] Natl Ctr Neurol & Psychiat, Natl Inst Neurosci, Div Dev & Differentiat, Kodaira, Tokyo 1878502, Japan.
[Fujita, Eriko; Yu, Zhiling; Yamagata, Takanori; Momoi, Mariko Y.] Jichi Med Univ, Dept Pediat, Shimotsuke, Tochigi 3290498, Japan.
RP Onaka, T (reprint author), Jichi Med Univ, Div Brain & Neurophysiol, Dept Physiol, Shimotsuke, Tochigi 3290498, Japan.
EM tonaka@jichi.ac.jp
RI Onaka, Tatsushi/I-7115-2012
FU MEXT [20590237, 20020023, 20790194, 22120512, 22659050]; JSPS
FX This work was supported by KAKENHI (20590237, 20020023, 20790194,
22120512, 22659050) from MEXT and JSPS.
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NR 19
TC 20
Z9 20
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0006-291X
J9 BIOCHEM BIOPH RES CO
JI Biochem. Biophys. Res. Commun.
PD JUN 4
PY 2010
VL 396
IS 3
BP 703
EP 708
DI 10.1016/j.bbrc.2010.04.165
PG 6
WC Biochemistry & Molecular Biology; Biophysics
SC Biochemistry & Molecular Biology; Biophysics
GA 610DG
UT WOS:000278710200022
PM 20450890
ER
PT J
AU Siddiqui, TJ
Pancaroglu, R
Kang, Y
Rooyakkers, A
Craig, AM
AF Siddiqui, Tabrez J.
Pancaroglu, Raika
Kang, Yunhee
Rooyakkers, Amanda
Craig, Ann Marie
TI LRRTMs and Neuroligins Bind Neurexins with a Differential Code to
Cooperate in Glutamate Synapse Development
SO JOURNAL OF NEUROSCIENCE
LA English
DT Article
ID INHIBITORY SYNAPSES; ALPHA-NEUREXINS; CELL-ADHESION; SYNAPTOGENIC
PROTEINS; NERVOUS-SYSTEM; CA2+ CHANNELS; COMPLEX; AUTISM; PSD-95;
SCHIZOPHRENIA
AB Leucine-rich repeat transmembrane neuronal proteins (LRRTMs) were recently found to instruct presynaptic and mediate postsynaptic glutamatergic differentiation. In a candidate screen, here we identify neurexin-1 beta lacking an insert at splice site 4 (-S4) as a ligand for LRRTM2. Neurexins bind LRRTM2 with a similar affinity but distinct code from the code for binding neuroligin-1 (the predominant form of neuroligin-1 at glutamate synapses, containing the B splice site insert). Whereas neuroligin-1 binds to neurexins 1, 2, and 3 beta but not alpha variants, regardless of insert at splice site 4, LRRTM2 binds to neurexins 1, 2, and 3 alpha and beta variants specifically lacking an insert at splice site 4. We further show that this binding code is conserved in LRRTM1, the family member linked to schizophrenia and handedness, and that the code is functional in a coculture hemisynapse formation assay. Mutagenesis of LRRTM2 to prevent binding to neurexins abolishes presynaptic inducing activity of LRRTM2. Remarkably, mutagenesis of neurexins shows that the binding face on neurexin-1 beta (-S4) is highly overlapping for the structurally distinct LRRTM2 and neuroligin-1 partners. Finally, we explore here the interplay of neuroligin-1 and LRRTM2 in synapse regulation. In neuron cultures, LRRTM2 is more potent than neuroligin-1 in promoting synaptic differentiation, and, most importantly, these two families of neurexin-binding partners cooperate in an additive or synergistic manner. Thus, we propose a synaptic code hypothesis suggesting that neurexins are master regulators of the cooperative activities of LRRTMs and neuroligins.
C1 [Craig, Ann Marie] Univ British Columbia, Brain Res Ctr, Vancouver, BC V6T 2B5, Canada.
Univ British Columbia, Dept Psychiat, Vancouver, BC V6T 2B5, Canada.
RP Craig, AM (reprint author), Univ British Columbia, Brain Res Ctr, Room F149,2211 Wesbrook Mall, Vancouver, BC V6T 2B5, Canada.
EM amcraig@interchange.ubc.ca
RI Craig, Ann Marie/M-2054-2014
FU Canadian Institutes of Health Research [MOP84241]; National Institutes
of Health [MH70860]; Mind Foundation of British Columbia; Michael Smith
Foundation for Health Research; Bluma Tischler Postdoctoral Fellowship;
Canada Research Chair program
FX This work was supported by Canadian Institutes of Health Research Grant
MOP84241, National Institutes of Health Grant MH70860, the Mind
Foundation of British Columbia, a Michael Smith Foundation for Health
Research Postdoctoral Fellowship (T.J.S.), a Bluma Tischler Postdoctoral
Fellowship (Y.K.), and the Canada Research Chair program (A.M.C.). We
thank Xiling Zhou for excellent assistance with experiments, Dr. Filip
Van Petegem for advice on LRRTM2 mutagenesis and generating a structural
model, and Drs. Ethan R. Graf and Michael W. Linhoff for numerous
constructs.
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NR 44
TC 87
Z9 88
PU SOC NEUROSCIENCE
PI WASHINGTON
PA 11 DUPONT CIRCLE, NW, STE 500, WASHINGTON, DC 20036 USA
SN 0270-6474
J9 J NEUROSCI
JI J. Neurosci.
PD JUN 2
PY 2010
VL 30
IS 22
BP 7495
EP 7506
DI 10.1523/JNEUROSCI.0470-10.2010
PG 12
WC Neurosciences
SC Neurosciences & Neurology
GA 604OK
UT WOS:000278288200007
PM 20519524
ER
PT J
AU Wegiel, J
Kuchna, I
Nowicki, K
Imaki, H
Wegiel, J
Marchi, E
Ma, SY
Chauhan, A
Chauhan, V
Bobrowicz, TW
de Leon, M
Saint Louis, LA
Cohen, IL
London, E
Brown, WT
Wisniewski, T
AF Wegiel, Jerzy
Kuchna, Izabela
Nowicki, Krzysztof
Imaki, Humi
Wegiel, Jarek
Marchi, Elaine
Ma, Shuang Yong
Chauhan, Abha
Chauhan, Ved
Bobrowicz, Teresa Wierzba
de Leon, Mony
Saint Louis, Leslie A.
Cohen, Ira L.
London, Eric
Brown, W. Ted
Wisniewski, Thomas
TI The neuropathology of autism: defects of neurogenesis and neuronal
migration, and dysplastic changes
SO ACTA NEUROPATHOLOGICA
LA English
DT Article
DE Autism; Developmental neuropathology; Subependymal nodular dysplasia;
Heterotopia; Dysplasia
ID TUBEROUS SCLEROSIS COMPLEX; FOCAL CORTICAL DYSPLASIA; UNIPOLAR BRUSH
CELLS; MICROTUBULE-ASSOCIATED PROTEIN; ANTIDEPRESSANT TREATMENT;
REPETITIVE BEHAVIORS; CLINICAL-FEATURES; ENTORHINAL CORTEX; CEREBELLAR
CORTEX; INFANTILE-AUTISM
AB Autism is characterized by a broad spectrum of clinical manifestations including qualitative impairments in social interactions and communication, and repetitive and stereotyped patterns of behavior. Abnormal acceleration of brain growth in early childhood, signs of slower growth of neurons, and minicolumn developmental abnormalities suggest multiregional alterations. The aim of this study was to detect the patterns of focal qualitative developmental defects and to identify brain regions that are prone to developmental alterations in autism. Formalin-fixed brain hemispheres of 13 autistic (4-60 years of age) and 14 age-matched control subjects were embedded in celloidin and cut into 200-mu m-thick coronal sections, which were stained with cresyl violet and used for neuropathological evaluation. Thickening of the subependymal cell layer in two brains and subependymal nodular dysplasia in one brain is indicative of active neurogenesis in two autistic children. Subcortical, periventricular, hippocampal and cerebellar heterotopias detected in the brains of four autistic subjects (31%) reflect abnormal neuronal migration. Multifocal cerebral dysplasia resulted in local distortion of the cytoarchitecture of the neocortex in four brains (31%), of the entorhinal cortex in two brains (15%), of the cornu Ammonis in four brains and of the dentate gyrus in two brains. Cerebellar flocculonodular dysplasia detected in six subjects (46%), focal dysplasia in the vermis in one case, and hypoplasia in one subject indicate local failure of cerebellar development in 62% of autistic subjects. Detection of flocculonodular dysplasia in only one control subject and of a broad spectrum of focal qualitative neuropathological developmental changes in 12 of 13 examined brains of autistic subjects (92%) reflects multiregional dysregulation of neurogenesis, neuronal migration and maturation in autism, which may contribute to the heterogeneity of the clinical phenotype.
C1 [Wegiel, Jerzy; Kuchna, Izabela; Nowicki, Krzysztof; Imaki, Humi; Wegiel, Jarek; Marchi, Elaine; Ma, Shuang Yong; Wisniewski, Thomas] NYS Inst Basic Res Dev Disabil IBR, Dept Dev Neurobiol, Staten Isl, NY 10314 USA.
[de Leon, Mony; Saint Louis, Leslie A.; Wisniewski, Thomas] NYU, Dept Neurol, Sch Med, New York, NY 10016 USA.
[de Leon, Mony; Saint Louis, Leslie A.; Wisniewski, Thomas] NYU, Dept Pathol, Sch Med, New York, NY 10016 USA.
[de Leon, Mony; Saint Louis, Leslie A.; Wisniewski, Thomas] NYU, Sch Med, Dept Psychiat, New York, NY USA.
[Chauhan, Abha; Chauhan, Ved] IBR, Dept Neurochem, Staten Isl, NY USA.
[Bobrowicz, Teresa Wierzba] Inst Psychiat & Neurol, Dept Neuropathol, Warsaw, Poland.
[Cohen, Ira L.; London, Eric] IBR, Dept Psychol, Staten Isl, NY USA.
[Brown, W. Ted] IBR, Dept Human Genet, Staten Isl, NY USA.
[Saint Louis, Leslie A.] Corinthian Diagnost Radiol, New York, NY USA.
[de Leon, Mony] Nathan S Kline Inst Psychiat Res, Orangeburg, NY 10962 USA.
RP Wegiel, J (reprint author), NYS Inst Basic Res Dev Disabil IBR, Dept Dev Neurobiol, 1050 Forest Hill Rd, Staten Isl, NY 10314 USA.
EM jerzy.wegiel@omr.state.ny.us
FU New York State Office of Mental Retardation and Developmental
Disabilities; Department of Defense [AS073234]; Autism Speaks
(Princeton, NJ); National Institutes of Health, National Institute of
Child Health and Human Development [R01 HD43960]; PHS [R24-MH 068855];
National Institute of Child Health; Human Development Brain and Tissue
Bank for Developmental Disorders at the University of Maryland,
Baltimore; Brain Bank for Developmental Disabilities and Aging of the
New York State Institute for Basic Research in Developmental
Disabilities, Staten Island, NY
FX This study was supported in part by funds from the New York State Office
of Mental Retardation and Developmental Disabilities, a grant from the
Department of Defense Autism Spectrum Disorders Research Program
(AS073234, Program Project; J.W., T. W., A. C.), a grant from Autism
Speaks (Princeton, NJ), and grant R01 HD43960 (J.W.) from the National
Institutes of Health, National Institute of Child Health and Human
Development. Tissue and clinical records' acquisition was coordinated by
the Autism Tissue Program ( Princeton, NJ; Directors: Jane Pickett,
Ph.D. and Daniel Lightfoot, Ph.D.). The tissue was obtained from the
Harvard Brain Tissue Resource Center, Belmont, MA, supported in part by
PHS grant number R24-MH 068855; the National Institute of Child Health
and Human Development Brain and Tissue Bank for Developmental Disorders
at the University of Maryland, Baltimore; and the Brain Bank for
Developmental Disabilities and Aging of the New York State Institute for
Basic Research in Developmental Disabilities, Staten Island, NY. We
thank Drs. Helmut Hainsen and Christoph Schmitz for help in
implementation of the celloidin protocol, and Mrs. Jadwiga Wegiel, Cathy
Wang and En Wu Zhang for histology. We are deeply indebted to the
families of the tissue donors who have made this study possible.
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NR 114
TC 117
Z9 120
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0001-6322
J9 ACTA NEUROPATHOL
JI Acta Neuropathol.
PD JUN
PY 2010
VL 119
IS 6
BP 755
EP 770
DI 10.1007/s00401-010-0655-4
PG 16
WC Clinical Neurology; Neurosciences; Pathology
SC Neurosciences & Neurology; Pathology
GA 592VS
UT WOS:000277410300009
PM 20198484
ER
PT J
AU Calhoun, VD
Wu, L
Kiehl, KA
Eichele, T
Pearlson, GD
AF Calhoun, Vince D.
Wu, Lei
Kiehl, Kent A.
Eichele, Tom
Pearlson, Godfrey D.
TI Aberrant processing of deviant stimuli in schizophrenia revealed by
fusion of fMRI and EEG data
SO ACTA NEUROPSYCHIATRICA
LA English
DT Article
DE data fusion; event-related potential; functional magnetic resonance
imaging; independent component analysis; N2; schizophrenia
ID INDEPENDENT COMPONENT ANALYSIS; EVENT-RELATED POTENTIALS; AUDITORY
ODDBALL TASK; MISMATCH NEGATIVITY MMN; FUNCTIONAL MRI; TEMPORAL-LOBE;
GRAY-MATTER; 1ST-EPISODE SCHIZOPHRENIA; P300 ABNORMALITIES; BLIND
SEPARATION
AB Background: Aberrant electrophysiological and haemodynamic processing of auditory oddball stimuli is among the most robustly documented findings in patients with schizophrenia. However, no study to date has directly examined linked patterns of electrical and haemodynamic differences in patients and controls.
Methods: In a recent paper we demonstrated a data-driven approach, joint independent component analysis (jICA) to fuse together functional magnetic resonance imaging (fMRI) and event-related potential (ERP) data and elucidated the chronometry of auditory oddball target detection in healthy control subjects. In this paper we extend our fusion method to identify specific differences in the neuronal chronometry of target detection for chronic schizophrenia patients compared to healthy controls.
Results: We found one linked source, consistent with the N2 response, known to be related to cognitive processing of deviant stimuli, spatially localized to bilateral fronto-temporal regions. This source showed significant between-group differences both in amplitude response and in the fMRI/ERP distribution pattern. These findings are consistent with previous work showing N2 amplitude and latency abnormalities in schizophrenia, and provide new information about the linkage between the two.
Conclusions: In summary, we use a novel approach to isolate and identify a linked fMRI/ERP component which shows marked differences in chronic schizophrenia patients. We also show that jointly using both fMRI and ERP measures provides a fully picture of the underlying haemodynamic and electrical changes which are present in patients. Our approach also has broad applicability to other diseases such as autism, Alzheimer's disease, or bipolar disorder.
C1 [Calhoun, Vince D.; Wu, Lei; Kiehl, Kent A.] Mind Res Network, Albuquerque, NM 87131 USA.
[Calhoun, Vince D.; Wu, Lei] Univ New Mexico, Dept ECE, Albuquerque, NM 87131 USA.
[Calhoun, Vince D.; Kiehl, Kent A.; Pearlson, Godfrey D.] Olin Neuropsychiat Res Ctr, Inst Living, Hartford, CT 06106 USA.
[Calhoun, Vince D.; Kiehl, Kent A.; Pearlson, Godfrey D.] Yale Univ, Dept Psychiat, Sch Med, New Haven, CT 06520 USA.
[Kiehl, Kent A.] Univ New Mexico, Dept Psychol, Albuquerque, NM 87131 USA.
[Eichele, Tom] Univ Bergen, Dept Biol & Med Psychol, N-5009 Bergen, Norway.
RP Calhoun, VD (reprint author), Mind Res Network, 1101 Yale Blvd NE, Albuquerque, NM 87106 USA.
EM vcalhoun@unm.edu
FU National Institutes of Health [1 R01 EB 006841, 1 R01 EB 005846, 1 R01
MH 0705539, 5 R37 MH 43775, 1 RO1 MH 074797, 1 R01 MH 077945]; two
Hartford Hospital Open Grant; two National Alliance for Research on
Schizophrenia and Depression Young Investigator; Distinguished
Investigator; L. Meltzer university fund [801616]
FX This research was supported in part by the National Institutes of
Health, under grants 1 R01 EB 006841, 1 R01 EB 005846 (V. D. C), 1 R01
MH 0705539 (K. A. K), 5 R37 MH 43775, 1 RO1 MH 074797, 1 R01 MH 077945
(G. D. P) and by two Hartford Hospital Open Grant Competition Awards (V.
D. C and K. A. K), two National Alliance for Research on Schizophrenia
and Depression Young Investigator Awards (V. D. C and K. A. K) and a
Distinguished Investigator Award (G. D. P) and a grant from the L.
Meltzer university fund 801616 (T. E.). We thank the research staff at
the Olin Neuropsychiatry Research Center and the Mind Research Network
who helped collect and process the data.All authors have contributed
substantially to the manuscript and none have financial interests to
disclose.
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NR 86
TC 11
Z9 11
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0924-2708
J9 ACTA NEUROPSYCHIATR
JI Acta Neuropsychiatr.
PD JUN
PY 2010
VL 22
IS 3
BP 127
EP 138
DI 10.1111/j.1601-5215.2010.00467.x
PG 12
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA 591RD
UT WOS:000277319500004
ER
PT J
AU Wasilewska, J
Kaczmarski, M
AF Wasilewska, J.
Kaczmarski, M.
TI Immunological abnormalities in children with autism
SO ALLERGY
LA English
DT Meeting Abstract
CT 29th Congress of the European-Academy-of-Allergy-and-Clinical-Immunology
(EAACI)
CY JUN 05-09, 2010
CL London, ENGLAND
SP European Acad Allergy and Clin Immunol
C1 [Wasilewska, J.; Kaczmarski, M.] Med Univ Bialystok, Dept Pediat, Bialystok, Poland.
NR 0
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0105-4538
EI 1398-9995
J9 ALLERGY
JI Allergy
PD JUN
PY 2010
VL 65
SU 92
SI SI
MA 789
BP 303
EP 304
PG 2
WC Allergy; Immunology
SC Allergy; Immunology
GA 286IR
UT WOS:000329462101271
ER
PT J
AU Main, PAE
Angley, MT
Thomas, P
O'Doherty, CE
Fenech, M
AF Main, Penelope A. E.
Angley, Manya T.
Thomas, Philip
O'Doherty, Catherine E.
Fenech, Michael
TI Folate and methionine metabolism in autism: a systematic review
SO AMERICAN JOURNAL OF CLINICAL NUTRITION
LA English
DT Review
ID OXIDATIVE STRESS; AMINO-ACIDS; DEVELOPMENTAL NEUROTOXICITY;
SCHIZOPHRENIC-PATIENTS; ALZHEIMERS-DISEASE; SPECTRUM DISORDER;
INFANTILE-AUTISM; FOLIC-ACID; CHILDREN; HOMOCYSTEINE
AB Background: Autism is a complex neurodevelopmental disorder that is increasingly being recognized as a public health issue. Recent evidence has emerged that children with autism may have altered folate or methionine metabolism, which suggests the folate-methionine cycle may play a key role in the etiology of autism.
Objective: The objective was to conduct a systematic review to examine the evidence for the involvement of alterations in folate-methionine metabolism in the etiology of autism.
Design: A systematic literature review was conducted of studies reporting data for metabolites, interventions, or genes of the folate-methionine pathway in autism. Eighteen studies met the inclusion criteria, 17 of which provided data on metabolites, 5 on interventions, and 6 on genes and their related polymorphisms.
Results: The findings of the review were conflicting. The variance in results can be attributed to heterogeneity between subjects with autism, sampling issues, and the wide range of analytic techniques used. Most genetic studies were inadequately powered to provide more than an indication of likely genetic relations.
Conclusions: The review concluded that further research is required with appropriately standardized and adequately powered study designs before any definitive conclusions can be made about the role for a dysfunctional folate-methionine pathway in the etiology of autism. There is also a need to determine whether functional benefits occur when correcting apparent deficits in folate-methionine metabolism in children with autism. Am J Clin Nutr 2010;91:1598-620.
C1 [Main, Penelope A. E.; Thomas, Philip; Fenech, Michael] CSIRO, Adelaide, SA 5000, Australia.
[Main, Penelope A. E.; Angley, Manya T.; O'Doherty, Catherine E.] Univ S Australia, Sansom Inst, Autism Res Grp, Adelaide, SA 5001, Australia.
RP Main, PAE (reprint author), CSIRO, Gate 13 Kintore St, Adelaide, SA 5000, Australia.
EM penelope.main@postgrads.unisa.edu.au
RI O'Doherty, Catherine/A-1212-2011; King, Catherine/F-4007-2013
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NR 52
TC 20
Z9 20
PU AMER SOC CLINICAL NUTRITION
PI BETHESDA
PA 9650 ROCKVILLE PIKE, SUBSCRIPTIONS, RM L-3300, BETHESDA, MD 20814-3998
USA
SN 0002-9165
J9 AM J CLIN NUTR
JI Am. J. Clin. Nutr.
PD JUN
PY 2010
VL 91
IS 6
BP 1598
EP 1620
DI 10.3945/ajcn.2009.29002
PG 23
WC Nutrition & Dietetics
SC Nutrition & Dietetics
GA 598MP
UT WOS:000277841700010
PM 20410097
ER
PT J
AU Burstyn, I
Sithole, F
Zwaigenbaum, L
AF Burstyn, I.
Sithole, F.
Zwaigenbaum, L.
TI AUTISM SPECTRUM DISORDERS, MATERNAL CHARACTERISTICS AND OBSTETRIC
COMPLICATIONS AMONG SINGLETONS BORN IN ALBERTA, CANADA
SO AMERICAN JOURNAL OF EPIDEMIOLOGY
LA English
DT Meeting Abstract
CT 43rd Annual Meeting of the Society-for-Epidemiologic-Research
CY JUN 23-26, 2010
CL Anaheim, SOLOMON ISLANDS
SP Soc Epidemiol Res
C1 [Burstyn, I.; Sithole, F.; Zwaigenbaum, L.] Drexel Univ, Pensivania, PA 19102 USA.
NR 0
TC 0
Z9 0
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0002-9262
J9 AM J EPIDEMIOL
JI Am. J. Epidemiol.
PD JUN 1
PY 2010
VL 171
SU 11
BP S43
EP S43
PG 1
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 603QO
UT WOS:000278223300172
ER
PT J
AU Gal, G
Gross, R
AF Gal, G.
Gross, R.
TI TIME TRENDS IN REPORTED AUTISM SPECTRUM DISORDERS IN ISRAEL (1986-2005)
SO AMERICAN JOURNAL OF EPIDEMIOLOGY
LA English
DT Meeting Abstract
CT 43rd Annual Meeting of the Society-for-Epidemiologic-Research
CY JUN 23-26, 2010
CL Anaheim, SOLOMON ISLANDS
SP Soc Epidemiol Res
C1 [Gal, G.; Gross, R.] Gertner Inst Epidemiol & Hlth Policy Res, Sheba Med Ctr, Tel Hashomer, Israel.
NR 0
TC 0
Z9 0
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0002-9262
J9 AM J EPIDEMIOL
JI Am. J. Epidemiol.
PD JUN 1
PY 2010
VL 171
SU 11
BP S94
EP S94
PG 1
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 603QO
UT WOS:000278223300374
ER
PT J
AU Hertz-Picciotto, I
Delwiche, L
Hansen, R
Pessah, IN
AF Hertz-Picciotto, I.
Delwiche, L.
Hansen, R.
Pessah, I. N.
TI HOUSEHOLD PESTICIDE USE IN RELATION TO AUTISM
SO AMERICAN JOURNAL OF EPIDEMIOLOGY
LA English
DT Meeting Abstract
CT 43rd Annual Meeting of the Society-for-Epidemiologic-Research
CY JUN 23-26, 2010
CL Anaheim, SOLOMON ISLANDS
SP Soc Epidemiol Res
C1 [Hertz-Picciotto, I.; Delwiche, L.; Hansen, R.; Pessah, I. N.] Univ Calif Davis, Davis, CA 95616 USA.
NR 0
TC 0
Z9 0
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0002-9262
J9 AM J EPIDEMIOL
JI Am. J. Epidemiol.
PD JUN 1
PY 2010
VL 171
SU 11
BP S100
EP S100
PG 1
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 603QO
UT WOS:000278223300399
ER
PT J
AU Lutsky, M
Yoshida, C
Green, P
Kharrazi, M
Croen, LA
AF Lutsky, M.
Yoshida, C.
Green, P.
Kharrazi, M.
Croen, L. A.
TI PRENATAL AND NEONATAL PERIPHERAL BLOOD MERCURY LEVELS AND AUTISM
SPECTRUM DISORDERS
SO AMERICAN JOURNAL OF EPIDEMIOLOGY
LA English
DT Meeting Abstract
CT 43rd Annual Meeting of the Society-for-Epidemiologic-Research
CY JUN 23-26, 2010
CL Anaheim, SOLOMON ISLANDS
SP Soc Epidemiol Res
C1 [Lutsky, M.; Yoshida, C.; Green, P.; Kharrazi, M.; Croen, L. A.] Kaiser Permanente, Div Res, Oakland, CA 94612 USA.
NR 0
TC 0
Z9 0
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0002-9262
J9 AM J EPIDEMIOL
JI Am. J. Epidemiol.
PD JUN 1
PY 2010
VL 171
SU 11
BP S110
EP S110
PG 1
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 603QO
UT WOS:000278223300440
ER
PT J
AU Lyall, K
Pauls, D
Spiegelman, D
Ascherio, A
Santangelo, S
AF Lyall, K.
Pauls, D.
Spiegelman, D.
Ascherio, A.
Santangelo, S.
TI PREGNANCY COMPLICATIONS AND OBSTETRIC SUBOPTIMALITY AS RISK FACTORS FOR
AUTISM SPECTRUM DISORDERS IN CHILDREN OF THE NURSES' HEALTH STUDY II
SO AMERICAN JOURNAL OF EPIDEMIOLOGY
LA English
DT Meeting Abstract
CT 43rd Annual Meeting of the Society-for-Epidemiologic-Research
CY JUN 23-26, 2010
CL Anaheim, CA
SP Soc Epidemiol Res
C1 [Lyall, K.; Pauls, D.; Spiegelman, D.; Ascherio, A.; Santangelo, S.] Harvard Univ, Sch Publ Hlth, Boston, MA 02115 USA.
NR 0
TC 0
Z9 0
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0002-9262
J9 AM J EPIDEMIOL
JI Am. J. Epidemiol.
PD JUN 1
PY 2010
VL 171
SU 11
BP S89
EP S89
PG 1
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 603QO
UT WOS:000278223300354
ER
PT J
AU Lyall, K
Pauls, D
Santangelo, S
Spiegelman, D
Ascherio, A
AF Lyall, K.
Pauls, D.
Santangelo, S.
Spiegelman, D.
Ascherio, A.
TI ASSOCIATION BETWEEN OVULATION INDUCING DRUG USE, INFERTILITY, AND AUTISM
SPECTRUM DISORDERS IN THE NURSES' HEALTH STUDY II
SO AMERICAN JOURNAL OF EPIDEMIOLOGY
LA English
DT Meeting Abstract
CT 43rd Annual Meeting of the Society-for-Epidemiologic-Research
CY JUN 23-26, 2010
CL Anaheim, CA
SP Soc Epidemiol Res
C1 [Lyall, K.; Pauls, D.; Santangelo, S.; Spiegelman, D.; Ascherio, A.] Harvard Univ, Sch Publ Hlth, Boston, MA 02115 USA.
NR 0
TC 0
Z9 0
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0002-9262
J9 AM J EPIDEMIOL
JI Am. J. Epidemiol.
PD JUN 1
PY 2010
VL 171
SU 11
BP S89
EP S89
PG 1
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 603QO
UT WOS:000278223300356
ER
PT J
AU Bedoyan, JK
Kumar, RA
Sudi, J
Silverstein, F
Ackley, T
Iyer, RK
Christian, SL
Martin, DM
AF Bedoyan, Jirair K.
Kumar, Ravinesh A.
Sudi, Jyotsna
Silverstein, Faye
Ackley, Todd
Iyer, Ramaswamy K.
Christian, Susan L.
Martin, Donna M.
TI Duplication 16p11.2 in a Child With Infantile Seizure Disorder
SO AMERICAN JOURNAL OF MEDICAL GENETICS PART A
LA English
DT Article
DE autism; seizure; 16p11.2; microarrays; DOC2A; QPRT; SEZ6L2
ID MIGRATING PARTIAL SEIZURES; GENOMIC DISORDERS; CANDIDATE GENES; AUTISM;
PROTEIN; INFANCY; MICRODELETIONS; REARRANGEMENTS; ASSOCIATION; PHENOTYPE
AB Submicroscopic recurrent 16p11.2 rearrangements are associated with several neurodevelopmental disorders, including autism, mental retardation, and schizophrenia. The common 16p11.2 region includes 24 known genes, of which 22 are expressed in the developing human fetal nervous system. As yet, the mechanisms leading to neurodevelopmental abnormalities and the broader phenotypes associated with deletion or duplication of 16p11.2 have not been clarified. Here we report a child with spastic quadriparesis, refractory infantile seizures, severe global developmental delay, hypotonia, and microcephaly, and a de novo 598 kb 16p11.2 microduplication. Family history is negative for any of these features in parents and immediate family members. Sequencing analyses showed no mutations in DOC2A, QPRT, and SEZ6L2, genes within the duplicated 16p11.2 region that have been implicated in neuronal function and/or seizure related phenotypes. The child's clinical course is consistent with a rare seizure disorder called malignant migrating partial seizure disorder of infancy, raising the possibility that duplication or disruption of genes in the 16p11.2 interval may contribute to this severe disorder. (C) 2010 Wiley-Liss, Inc.
C1 [Bedoyan, Jirair K.; Silverstein, Faye; Ackley, Todd; Iyer, Ramaswamy K.; Martin, Donna M.] Univ Michigan, Dept Pediat, Ann Arbor, MI 48109 USA.
[Martin, Donna M.] Univ Michigan, Dept Human Genet, Ann Arbor, MI 48109 USA.
[Iyer, Ramaswamy K.] Univ Michigan, Dept Pathol, Ann Arbor, MI 48109 USA.
[Kumar, Ravinesh A.; Sudi, Jyotsna; Christian, Susan L.] Univ Chicago, Dept Human Genet, Chicago, IL 60637 USA.
RP Martin, DM (reprint author), Univ Michigan, Dept Pediat, 3520A MSRB 1,1150 W Med Ctr Dr, Ann Arbor, MI 48109 USA.
EM donnamm@umich.edu
FU NIH [DC009410, NS054784]; MMGL; Department of Pediatrics; Department of
Human Genetics; University of Michigan [UL1RR024986]; Autism Speaks
FX Grant sponsor: NIH; Grant numbers: DC009410, NS054784.We thank Dr.
Jeffrey W. Innis for critical review of this manuscript and for support
through MMGL. This study was also supported by funds from MMGL, the
Department of Pediatrics, the Department of Human Genetics, and a CTSA
pilot award (UL1RR024986) from the University of Michigan. RAK is
supported by a postdoctoral fellowship award from Autism Speaks. DMM is
supported by NIH grants DC009410 and NS054784.
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NR 29
TC 19
Z9 22
PU WILEY-LISS
PI HOBOKEN
PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 1552-4825
J9 AM J MED GENET A
JI Am. J. Med. Genet. A
PD JUN
PY 2010
VL 152A
IS 6
BP 1567
EP 1574
DI 10.1002/ajmg.a.33415
PG 8
WC Genetics & Heredity
SC Genetics & Heredity
GA 610RJ
UT WOS:000278752000033
PM 20503337
ER
PT J
AU Ching, MSL
Shen, YP
Tan, WH
Jeste, SS
Morrow, EM
Chen, XL
Mukaddes, NM
Yoo, SY
Hanson, E
Hundley, R
Austin, C
Becker, RE
Berry, GT
Driscoll, K
Engle, EC
Friedman, S
Gusella, JF
Hisama, FM
Irons, MB
Lafiosca, T
LeClair, E
Miller, DT
Neessen, M
Picker, JD
Rappaport, L
Rooney, CM
Sarco, DP
Stoler, JM
Walsh, CA
Wolff, RR
Zhang, T
Nasir, RH
Wu, BL
AF Ching, Michael S. L.
Shen, Yiping
Tan, Wen-Hann
Jeste, Shafali S.
Morrow, Eric M.
Chen, Xiaoli
Mukaddes, Nahit M.
Yoo, Seung-Yun
Hanson, Ellen
Hundley, Rachel
Austin, Christina
Becker, Ronald E.
Berry, Gerard T.
Driscoll, Katherine
Engle, Elizabeth C.
Friedman, Sandra
Gusella, James F.
Hisama, Fuki M.
Irons, Mira B.
Lafiosca, Tina
LeClair, Elaine
Miller, David T.
Neessen, Michael
Picker, Jonathan D.
Rappaport, Leonard
Rooney, Cynthia M.
Sarco, Dean P.
Stoler, Joan M.
Walsh, Christopher A.
Wolff, Robert R.
Zhang, Ting
Nasir, Ramzi H.
Wu, Bai-Lin
CA Childrens Hosp Boston Genotype Phe
TI Deletions of NRXN1 (Neurexin-1) Predispose to a Wide Spectrum of
Developmental Disorders
SO AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
LA English
DT Article
DE NRXN1 (neurexin-1); developmental disorders; array CGH; NRXN1 exonic
deletions; CNV
ID ALPHA-NEUREXINS; STRUCTURAL VARIANTS; NICOTINE DEPENDENCE; CA2+
CHANNELS; AUTISM; GENES; SCHIZOPHRENIA; ASSOCIATION; NEUROLIGINS;
COMPLEX
AB Research has implicated mutations in the gene for neurexin-1 (NRXN1) in a variety of conditions including autism, schizophrenia, and nicotine dependence. To our knowledge, there have been no published reports describing the breadth of the phenotype associated with mutations in NRXN1. We present a medical record review of subjects with deletions involving exonic sequences of NRXN1. We ascertained cases from 3,540 individuals referred clinically for comparative genomic hybridization testing from March 2007 to January 2009. Twelve subjects were identified with exonic deletions. The phenotype of individuals with NRXN1 deletion is variable and includes autism spectrum disorders, mental retardation, language delays, and hypotonia. There was a statistically significant increase in NRXN1 deletion in our clinical sample compared to control populations described in the literature (P=8.9 x 10(-7)). Three additional subjects with NRXN1 deletions and autism were identified through the Homozygosity Mapping Collaborative for Autism, and this deletion segregated with the phenotype. Our study indicates that deletions of NRXN1 predispose to a wide spectrum of developmental disorders. (C) 2010 Wiley-Liss, Inc.
C1 [Nasir, Ramzi H.] Harvard Univ, Sch Med, Div Dev Med, Childrens Hosp Boston, Boston, MA 02115 USA.
[Gusella, James F.] Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA.
[Shen, Yiping; Gusella, James F.] Massachusetts Gen Hosp, Ctr Human Genet Res, Boston, MA 02114 USA.
[Tan, Wen-Hann; Yoo, Seung-Yun; Austin, Christina; Berry, Gerard T.; Hisama, Fuki M.; Irons, Mira B.; Miller, David T.; Picker, Jonathan D.; Stoler, Joan M.; Walsh, Christopher A.] Childrens Hosp Boston, Div Genet, Boston, MA USA.
[Jeste, Shafali S.; Engle, Elizabeth C.; Rooney, Cynthia M.; Sarco, Dean P.; Wolff, Robert R.] Childrens Hosp Boston, Dept Neurol, Boston, MA USA.
[Morrow, Eric M.] Brown Univ, Dept Mol Biol Cell Biol & Biochem, Providence, RI 02912 USA.
[Shen, Yiping; Chen, Xiaoli; Miller, David T.; Wu, Bai-Lin] Childrens Hosp Boston, Dept Lab Med, Boston, MA USA.
[Chen, Xiaoli; Zhang, Ting] Capital Inst Pediat, Dept Mol Immunol, Beijing, Peoples R China.
[Mukaddes, Nahit M.] Istanbul Univ, Istanbul Fac Med, Dept Child Psychiat, Istanbul, Turkey.
[Engle, Elizabeth C.] Childrens Hosp Boston, Howard Hughes Med Inst, Boston, MA USA.
[Engle, Elizabeth C.; Walsh, Christopher A.] Childrens Hosp Boston, Manton Ctr Orphan Dis Res, Boston, MA USA.
[Engle, Elizabeth C.] Childrens Hosp Boston, Dept Ophthalmol, Boston, MA USA.
[Walsh, Christopher A.] Beth Israel Deaconess Med Ctr, Howard Hughes Med Inst, Boston, MA 02215 USA.
[Wu, Bai-Lin] Fudan Univ, Childrens Hosp, Shanghai 200433, Peoples R China.
[Wu, Bai-Lin] Fudan Univ, Inst Biomed Sci, Shanghai 200433, Peoples R China.
RP Nasir, RH (reprint author), Harvard Univ, Sch Med, Div Dev Med, Childrens Hosp Boston, 300 Longwood Ave, Boston, MA 02115 USA.
EM ramzi.nasir@childrens.harvard.edu; bai-lin.wu@childrens.harvard.edu
RI Morrow, Eric/J-2767-2013
FU Nancy Lurie Marks Family Foundation; Simons Foundation; Autism Speaks;
NIH [5K23MH080954-02, 1R01MH083565]; Children's Tumor Foundation;
Harvard Medical School; Burroughs Wellcome Fund; Fudan University
FX The authors gratefully acknowledge the assistance by our colleagues from
the DNA Diagnostics Lab: Va Lip, Xiaoming Sheng, Ann Reinhard, Hong
Fang, Sly Tang, Hong Shao, Haitao Zhu, Sam Tang, and Andrew Cheng for
technical support of array CGH; Christopher A. Walsh Lab: Danielle
Gleason and Daniel Rakiec for technical support and Robert Sean Hill for
bioinformatics support. We are further grateful for the support from the
Nancy Lurie Marks Family Foundation (C.A.W.), the Simons Foundation
(C.A.W. and J.F.G.), Autism Speaks (J.F.G.), and the NIH
(5K23MH080954-02 to E.M.M. and 1R01MH083565 to C.A.W). E.C.E. and C.A.W.
are Investigators of the Howard Hughes Medical Institute. Y.S. holds a
Young Investigator Award from the Children's Tumor Foundation and
Catalyst Award from Harvard Medical School, E.M.M. holds a Career Award
for Medical Scientists from the Burroughs Wellcome Fund, B.L.W. holds a
Fudan Scholar Research Award from Fudan University.
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NR 51
TC 111
Z9 111
PU WILEY-LISS
PI HOBOKEN
PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 1552-4841
J9 AM J MED GENET B
JI Am. J. Med. Genet. B
PD JUN
PY 2010
VL 153B
IS 4
BP 937
EP 947
DI 10.1002/ajmg.b.31063
PG 11
WC Genetics & Heredity; Psychiatry
SC Genetics & Heredity; Psychiatry
GA 604AT
UT WOS:000278250400009
PM 20468056
ER
PT J
AU van der Zwaag, B
Staal, WG
Hochstenbach, R
Poot, M
Spierenburg, HA
de Jonge, MV
Verbeek, NE
van't Slot, R
van Es, MA
Staal, FJ
Freitag, CM
Buizer-Voskamp, JE
Nelen, MR
van den Berg, LH
van Amstel, HKP
van Engeland, H
Burbach, JPH
AF van der Zwaag, Bert
Staal, Wouter G.
Hochstenbach, Ron
Poot, Martin
Spierenburg, Henk A.
de Jonge, Maretha V.
Verbeek, Nienke E.
van't Slot, Ruben
van Es, Michael A.
Staal, Frank J.
Freitag, Christine M.
Buizer-Voskamp, Jacobine E.
Nelen, Marcel R.
van den Berg, Leonard H.
van Amstel, Hans K. Ploos
van Engeland, Herman
Burbach, J. Peter H.
TI A Co-segregating Microduplication of Chromosome 15q11.2 Pinpoints Two
Risk Genes for Autism Spectrum Disorder
SO AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
LA English
DT Article
DE autism spectrum disorder; genetics; copy-number; gene-dosage; gene
expression
ID PRADER-WILLI; NEURONAL CONNECTIVITY; CRITICAL REGION; DROSOPHILA;
PROTEIN
AB High resolution genomic copy-number analysis has shown that inherited and de novo copy-number variations contribute significantly to autism pathology, and that identification of small chromosomal aberrations related to autism will expedite the discovery of risk genes involved. Here, we report a microduplication of chromosome 15q11.2, spanning only four genes, co-segregating with autism in a Dutch pedigree, identified by SNP microarray analysis, and independently confirmed by FISH and MLPA analysis. Quantitative RT-PCR analysis revealed over 70% increase in peripheral blood mRNA levels for the four genes present in the duplicated region in patients, and RNA in situ hybridization on mouse embryonic and adult brain sections revealed that two of the four genes, CYFIP1 and NIPA1, were highly expressed in the developing mouse brain. These findings point towards a contribution of microduplications at chromosome 15q11.2 to autism, and highlight CYFIP1 and NIPA1 as autism risk genes functioning in axonogenesis and synapto-genesis. Thereby, these findings further implicate defects in dosage-sensitive molecular control of neuronal connectivity in autism. However, the prevalence of this microduplication in patient samples was statistically not significantly different from control samples (0.94% in patients vs. 0.42% controls, P= 0.247), which suggests that our findings should be interpreted with caution and indicates the need for studies that include large numbers of control subjects to ascertain the impact of these changes on a population scale. (C) 2009 Wiley-Liss, Inc.
C1 [van der Zwaag, Bert; Spierenburg, Henk A.; Burbach, J. Peter H.] UMC Utrecht, Rudolf Magnus Inst Neurosci, Dept Neurosci & Pharmacol, Utrecht, Netherlands.
[Staal, Wouter G.; de Jonge, Maretha V.; van Engeland, Herman] UMC Utrecht, Rudolf Magnus Inst Neurosci, Dept Child & Adolescent Psychiat, Utrecht, Netherlands.
[Hochstenbach, Ron; Poot, Martin; Verbeek, Nienke E.; Nelen, Marcel R.; van Amstel, Hans K. Ploos] UMC Utrecht, Dept Med Genet, Utrecht, Netherlands.
[van't Slot, Ruben; Buizer-Voskamp, Jacobine E.] UMC Utrecht, Dept Biomed Genet, Complex Genet Sect, Utrecht, Netherlands.
[van Es, Michael A.; van den Berg, Leonard H.] UMC Utrecht, Dept Neurol, Rudolf Magnus Inst Neurosci, Utrecht, Netherlands.
[Staal, Frank J.] Erasmus MC, Dept Immunol, Rotterdam, Netherlands.
[Freitag, Christine M.] Saarland Univ Hosp, Dept Child & Adolescent Psychiat, Homburg, Germany.
[Buizer-Voskamp, Jacobine E.] Univ Med Ctr Utrecht, Dept Psychiat, Rudolf Magnus Inst Neurosci, Utrecht, Netherlands.
RP Burbach, JPH (reprint author), Univ Weg 100, NL-3584 CG Utrecht, Netherlands.
EM j.p.h.burbach@umcutrecht.nl
RI Poot, Martin/F-9427-2010; Staal, Wouter/A-3099-2013
FU Breedtestrategie program; Utrecht University; Hersenstichting
(Netherlands Foundation) [2008(1).43]; Autism Genetic Resource Exchange
(AGRE); Autism Speaks; National Institute of Mental Health
[1U24MH081810]
FX We thank the ASD family and healthy control individuals for their
participation in this study. B. van der Zwaag was supported by the
"Breedtestrategie" program and the Prestigous Master Neuroscience and
Cognition of the Utrecht University. Part of this research was funded by
the Hersenstichting (Netherlands Foundation for Brain Research), grant
#2008(1).43 to M. Poot. We gratefully acknowledge the resources provided
by the Autism Genetic Resource Exchange (AGRE) Consortium and the
participating AGRE families. The Autism Genetic Resource Exchange is a
program of Autism Speaks and is supported, in part, by grant
1U24MH081810 from the National Institute of Mental Health to Clara M.
Lajonchere (PI).
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Wechsler D., 1974, MANUAL WECHSLER INTE
Zalfa F, 2006, CURR OPIN NEUROBIOL, V16, P265, DOI 10.1016/j.conb.2006.05.010
NR 30
TC 29
Z9 29
PU WILEY-LISS
PI HOBOKEN
PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 1552-4841
J9 AM J MED GENET B
JI Am. J. Med. Genet. B
PD JUN
PY 2010
VL 153B
IS 4
BP 960
EP 966
DI 10.1002/ajmg.b.31055
PG 7
WC Genetics & Heredity; Psychiatry
SC Genetics & Heredity; Psychiatry
GA 604AT
UT WOS:000278250400012
PM 20029941
ER
PT J
AU Sokhadze, E
Baruth, J
Tasman, A
Mansoor, M
Ramaswamy, R
Sears, L
Mathai, G
El-Baz, A
Casanova, MF
AF Sokhadze, Estate
Baruth, Joshua
Tasman, Allan
Mansoor, Mehreen
Ramaswamy, Rajesh
Sears, Lonnie
Mathai, Grace
El-Baz, Ayman
Casanova, Manuel F.
TI Low-Frequency Repetitive Transcranial Magnetic Stimulation (rTMS)
Affects Event-Related Potential Measures of Novelty Processing in Autism
SO APPLIED PSYCHOPHYSIOLOGY AND BIOFEEDBACK
LA English
DT Article
DE Event-related potentials; Autism; Novelty; Transcranial Magnetic
Stimulation; Cortical excitation/inhibition balance; Minicolumns
ID DEVELOPMENTAL LANGUAGE DISORDER; AUDITORY-EVOKED POTENTIALS;
MINICOLUMNAR ORGANIZATION; BRAIN POTENTIALS; SELECTIVE ATTENTION;
MISMATCH NEGATIVITY; CHILDREN; ABNORMALITIES; DEPRESSION; CORTEX
AB In our previous study on individuals with autism spectrum disorder (ASD) (Sokhadze et al., Appl Psychophysiol Biofeedback 34:37-51, 2009a) we reported abnormalities in the attention-orienting frontal event-related potentials (ERP) and the sustained-attention centro-parietal ERPs in a visual oddball experiment. These results suggest that individuals with autism over-process information needed for the successful differentiation of target and novel stimuli. In the present study we examine the effects of low-frequency, repetitive Transcranial Magnetic Stimulation (rTMS) on novelty processing as well as behavior and social functioning in 13 individuals with ASD. Our hypothesis was that low-frequency rTMS application to dorsolateral prefrontal cortex (DLFPC) would result in an alteration of the cortical excitatory/inhibitory balance through the activation of inhibitory GABAergic double bouquet interneurons. We expected to find post-TMS differences in amplitude and latency of early and late ERP components. The results of our current study validate the use of low-frequency rTMS as a modulatory tool that altered the disrupted ratio of cortical excitation to inhibition in autism. After rTMS the parieto-occipital P50 amplitude decreased to novel distracters but not to targets; also the amplitude and latency to targets increased for the frontal P50 while decreasing to non-target stimuli. Low-frequency rTMS minimized early cortical responses to irrelevant stimuli and increased responses to relevant stimuli. Improved selectivity in early cortical responses lead to better stimulus differentiation at later-stage responses as was made evident by our P3b and P3a component findings. These results indicate a significant change in early, middle-latency and late ERP components at the frontal, centro-parietal, and parieto-occipital regions of interest in response to target and distracter stimuli as a result of rTMS treatment. Overall, our preliminary results show that rTMS may prove to be an important research tool or treatment modality in addressing the stimulus hypersensitivity characteristic of autism spectrum disorders.
C1 [Sokhadze, Estate; Baruth, Joshua; Tasman, Allan; Mansoor, Mehreen; Ramaswamy, Rajesh; El-Baz, Ayman; Casanova, Manuel F.] Univ Louisville, Dept Psychiat & Behav Sci, Sch Med, Louisville, KY 40292 USA.
[Sears, Lonnie; Mathai, Grace] Univ Louisville, Sch Med, Dept Pediat, Louisville, KY 40292 USA.
[Baruth, Joshua; Casanova, Manuel F.] Univ Louisville, Sch Med, Dept Anat Sci & Neurobiol, Louisville, KY 40292 USA.
RP Sokhadze, E (reprint author), Univ Louisville, Dept Psychiat & Behav Sci, Sch Med, Louisville, KY 40292 USA.
EM tato.sokhadze@louisville.edu
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NR 96
TC 20
Z9 20
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1090-0586
J9 APPL PSYCHOPHYS BIOF
JI Appl. Psychophysiol. Biofeedback
PD JUN
PY 2010
VL 35
IS 2
BP 147
EP 161
DI 10.1007/s10484-009-9121-2
PG 15
WC Psychology, Clinical
SC Psychology
GA 600YN
UT WOS:000278025200006
PM 19941058
ER
PT J
AU Sokhadze, ET
El-Baz, A
Baruth, J
Tasman, A
Mathai, G
Sears, L
Casanova, M
AF Sokhadze, Estate Tato
El-Baz, Ayman
Baruth, Joshua
Tasman, Allan
Mathai, Grace
Sears, Lonnie
Casanova, Manuel
TI Repetitive TMS Affects EEG Gamma and ERP During Perceptual Processing in
Autism
SO APPLIED PSYCHOPHYSIOLOGY AND BIOFEEDBACK
LA English
DT Meeting Abstract
DE TMS; Autism; EEG and ERP
C1 [Sokhadze, Estate Tato] Univ Louisville, Louisville, KY 40292 USA.
EM tato.sokhadze@louisville.edu
NR 0
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1090-0586
J9 APPL PSYCHOPHYS BIOF
JI Appl. Psychophysiol. Biofeedback
PD JUN
PY 2010
VL 35
IS 2
BP 178
EP 179
PG 2
WC Psychology, Clinical
SC Psychology
GA 600YN
UT WOS:000278025200013
ER
PT J
AU Coben, R
AF Coben, Robert
TI Efficacy of Connectivity Guided Neurofeedback on Language Functions and
IQ in Autistic Children
SO APPLIED PSYCHOPHYSIOLOGY AND BIOFEEDBACK
LA English
DT Meeting Abstract
DE EEG biofeedback; Autism; Language
EM drcoben@gmail.com
NR 0
TC 1
Z9 1
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1090-0586
J9 APPL PSYCHOPHYS BIOF
JI Appl. Psychophysiol. Biofeedback
PD JUN
PY 2010
VL 35
IS 2
BP 179
EP 179
PG 1
WC Psychology, Clinical
SC Psychology
GA 600YN
UT WOS:000278025200014
ER
PT J
AU Assouline, B
AF Assouline, B.
TI Autism announcement at consultation is a therapeutic step
SO ARCHIVES DE PEDIATRIE
LA French
DT Article
C1 Ctr Hosp St Egreve, CADIPA Ctr Ressources Autisme Rhone Alpes, Grenoble, France.
RP Assouline, B (reprint author), Ctr Hosp St Egreve, CADIPA Ctr Ressources Autisme Rhone Alpes, Grenoble, France.
EM bassouline@ch-saint-egreve.fr
CR BAGDHADLI A, 2005, RECOMMANDATIONS PRAT
BURSZTEJN C, 2006, DIAGNOSTIC PSYCHIAT, P81
DANONGRILLIAT A, 2006, DIAGNOSTIC PSYCHIAT, P65
*HAUT AUT SANT FED, 2008, DEP DIAGN AUT REC PR
Poirier Annie, 2008, J DEV DISAB, V14, P19
NR 5
TC 0
Z9 0
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI PARIS
PA 23 RUE LINOIS, 75724 PARIS, FRANCE
SN 0929-693X
J9 ARCH PEDIATRIE
JI Arch. Pediatr.
PD JUN
PY 2010
VL 17
IS 6
BP 647
EP 648
PG 2
WC Pediatrics
SC Pediatrics
GA 619GM
UT WOS:000279417200028
PM 20654823
ER
PT J
AU Amiet, C
Gourfinkel-An, I
Consoli, A
Perisse, D
Cohen, D
AF Amiet, C.
Gourfinkel-An, I.
Consoli, A.
Perisse, D.
Cohen, D.
TI Epilepsy and autism: a complex issue
SO ARCHIVES DE PEDIATRIE
LA French
DT Article
ID SPECTRUM DISORDERS
C1 [Amiet, C.; Gourfinkel-An, I.; Consoli, A.; Perisse, D.; Cohen, D.] Univ Paris 06, Grp Hosp Pitie Salpetriere, Serv Psychiat Enfant & Adolescent, Lab Psychol & Neurosci Cognit,CNRS,UMR 8189, F-75252 Paris 05, France.
RP Amiet, C (reprint author), Univ Paris 06, Grp Hosp Pitie Salpetriere, Serv Psychiat Enfant & Adolescent, Lab Psychol & Neurosci Cognit,CNRS,UMR 8189, F-75252 Paris 05, France.
EM claire.amiet@pst.aphp.fr
CR Amiet C, 2008, BIOL PSYCHIAT, V64, P577, DOI 10.1016/j.biopsych.2008.04.030
Canitano R, 2007, EUR CHILD ADOLES PSY, V16, P61, DOI 10.1007/s00787-006-0563-2
Casanova MF, 2003, NEUROSCIENTIST, V9, P496, DOI 10.1177/1073858403253552
Federation francaise de psychiatric, 2005, Recupere de
Jambaque I, 1998, J NEUROL NEUROSUR PS, V65, P555, DOI 10.1136/jnnp.65.4.555
Nass R, 1999, PEDIATR NEUROL, V21, P464, DOI 10.1016/S0887-8994(99)00029-6
Saemundsen E, 2007, EPILEPSIA, V48, P1724, DOI 10.1111/j.1528-1167.2007.01150.x
Tuchman R, 2002, LANCET NEUROL, V1, P352, DOI 10.1016/S1474-4422(02)00160-6
VOLKMAR FR, 1990, J AM ACAD CHILD PSY, V29, P127, DOI 10.1097/00004583-199001000-00020
NR 9
TC 0
Z9 0
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI PARIS
PA 23 RUE LINOIS, 75724 PARIS, FRANCE
SN 0929-693X
J9 ARCH PEDIATRIE
JI Arch. Pediatr.
PD JUN
PY 2010
VL 17
IS 6
BP 650
EP 651
PG 2
WC Pediatrics
SC Pediatrics
GA 619GM
UT WOS:000279417200030
PM 20654825
ER
PT J
AU Schiff, M
Delorme, R
Benoist, JF
de Baulny, HO
AF Schiff, M.
Delorme, R.
Benoist, J. -F.
de Baulny, H. Ogier
TI Should a metabolic work-up be performed in autism?
SO ARCHIVES DE PEDIATRIE
LA French
DT Article
ID SPECTRUM DISORDERS; YIELD
C1 [Schiff, M.; Benoist, J. -F.; de Baulny, H. Ogier] Hop Robert Debre, AP HP, Ctr Reference Malad Metab, F-75019 Paris, France.
[Schiff, M.; de Baulny, H. Ogier] Hop Robert Debre, AP HP, Serv Neuropediat, F-75019 Paris, France.
[Delorme, R.] Hop Robert Debre, AP HP, Serv Psychopathol Enfant & Adolescent, F-75019 Paris, France.
[Benoist, J. -F.] Hop Robert Debre, AP HP, Serv Biochim, F-75019 Paris, France.
RP Schiff, M (reprint author), Hop Robert Debre, AP HP, Ctr Reference Malad Metab, F-75019 Paris, France.
EM manuel.schiff@rdb.aphp.fr
CR Cohen D, 2005, J AUTISM DEV DISORD, V35, P103, DOI 10.1007/s10803-004-1038-2
KAYSER MA, 2008, PEDIATR NEUROL, V15, P127
Kosinovsky B, 2005, J NEURAL TRANSM, V112, P587, DOI 10.1007/s00702-004-0198-8
Levy SE, 2009, LANCET, V374, P1627, DOI 10.1016/S0140-6736(09)61376-3
Muhle R., 2004, PEDIATRICS, V113, P472
Schaefer GB, 2006, GENET MED, V8, P549, DOI 10.1097/01.gim.0000237789.98842.fi
Weissman JR, 2008, PLOS ONE, V3, DOI 10.1371/journal.pone.0003815
Zecavati N, 2009, CURR NEUROL NEUROSCI, V9, P129, DOI 10.1007/s11910-009-0021-x
NR 8
TC 4
Z9 4
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI PARIS
PA 23 RUE LINOIS, 75724 PARIS, FRANCE
SN 0929-693X
J9 ARCH PEDIATRIE
JI Arch. Pediatr.
PD JUN
PY 2010
VL 17
IS 6
BP 802
EP 803
PG 2
WC Pediatrics
SC Pediatrics
GA 619GM
UT WOS:000279417200106
PM 20654901
ER
PT J
AU Dawes, P
Bishop, DVM
AF Dawes, Piers
Bishop, Dorothy V. M.
TI Psychometric profile of children with auditory processing disorder and
children with dyslexia
SO ARCHIVES OF DISEASE IN CHILDHOOD
LA English
DT Article
ID LANGUAGE IMPAIRMENT; COMMUNICATION; AUTISM
AB Objective The aim was to address the controversy that exists over the extent to which auditory processing disorder (APD) is a separate diagnostic category with a distinctive psychometric profile, rather than a reflection of a more general learning disability.
Methods Children with an APD diagnosis (N=25) were compared with children with dyslexia (N=19) on a battery of standardised auditory processing, language, literacy and non-verbal intelligence quotient measures as well as parental report measures of communicative skill and listening behaviour. A follow-up of a subset of children included a parent report screening questionnaire for Asperger syndrome (Childhood Asperger Syndrome Test).
Results There were similarly high levels of attentional, reading and language problems in both groups. One peculiarity of the APD group was a discrepancy between parental report of poor communication and listening skill disproportionate to expectations based on standardised test performance. Follow-up assessment suggested high levels of previously unrecognised autistic features within the APD group.
Conclusions Children diagnosed by audiological experts as having APD are likely to have broader neurodevelopmental disorders and would benefit from evaluation by a multidisciplinary team.
C1 [Dawes, Piers] Univ Manchester, Dept Psychol, Audiol & Deafness Res Grp, Manchester M13 9PL, Lancs, England.
[Bishop, Dorothy V. M.] Univ Oxford, Dept Expt Psychol, Oxford OX1 3UD, England.
RP Dawes, P (reprint author), Univ Manchester, Dept Psychol, Audiol & Deafness Res Grp, Manchester M13 9PL, Lancs, England.
EM piers.dawes@manchester.ac.uk
FU Deafness Research UK
FX This study was funded by Deafness Research UK. Thank you to T Sirimanna
(Great Ormond Street Hospital), F Tweedy (Manchester Royal Infirmary), M
Burton (John Radcliffe Hospital) and I Vanniasegaram (St Georges
Hospital) for help with recruitment of subjects.
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Bishop DVM, 2004, EXPRESSION RECEPTION
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NR 32
TC 7
Z9 7
PU B M J PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 0003-9888
J9 ARCH DIS CHILD
JI Arch. Dis. Child.
PD JUN
PY 2010
VL 95
IS 6
BP 432
EP 436
DI 10.1136/adc.2009.170118
PG 5
WC Pediatrics
SC Pediatrics
GA 600QL
UT WOS:000278002000007
PM 20501538
ER
PT J
AU Bauminger, N
Solomon, M
Rogers, SJ
AF Bauminger, Nirit
Solomon, Marjorie
Rogers, Sally J.
TI Externalizing and Internalizing Behaviors in ASD
SO AUTISM RESEARCH
LA English
DT Article
DE psychopathology; adaptive behavior; high-functioning ASD; parental
stress
ID PERVASIVE DEVELOPMENTAL DISORDERS; SCHOOL-AGE-CHILDREN;
ASPERGER-SYNDROME; CONSCIENCE DEVELOPMENT; PSYCHIATRIC-DISORDERS;
ATTACHMENT SECURITY; PEER RELATIONSHIPS; AUTISTIC-CHILDREN; POSITIVE
AFFECT; YOUNG-CHILDREN
AB The current study investigated the relationships between internalizing and externalizing (I-E) behaviors and family variables, including both parenting stress and quality of attachment relations, in children aged 8-12 with high-functioning autism spectrum disorder (ASD) or with typical development. Compared to the group with typical development, children with ASD exhibited significantly greater levels of psychopathology as assessed by the Child Behavior Checklist [Achenbach, 1991], and parents of children with ASD exhibited higher parenting stress as assessed by the Parenting Stress Index [Abidin, 1995]. In a hierarchical multiple regression analysis, parenting stress emerged as the most important predictor of children's I-E problems. Results are discussed in light of the two groups' similar relationships between parenting stress and child psychopathology.
C1 [Bauminger, Nirit] Bar Ilan Univ, Sch Educ, IL-52900 Ramat Gan, Israel.
[Solomon, Marjorie; Rogers, Sally J.] UC Davis, Mind Inst, Dept Psychiat, Sacramento, CA USA.
RP Bauminger, N (reprint author), Bar Ilan Univ, Sch Educ, IL-52900 Ramat Gan, Israel.
EM bauminn@mail.biu.ac.il
FU United States-Israel Binational Science Foundation (BSF)
FX This study was supported by the United States-Israel Binational Science
Foundation (BSF) to Drs. Rogers and Bauminger.
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NR 74
TC 15
Z9 15
PU JOHN WILEY & SONS INC
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 1939-3792
J9 AUTISM RES
JI Autism Res.
PD JUN
PY 2010
VL 3
IS 3
BP 101
EP 112
DI 10.1002/aur.131
PG 12
WC Behavioral Sciences; Psychology, Developmental
SC Behavioral Sciences; Psychology
GA 620NV
UT WOS:000279507500001
PM 20575109
ER
PT J
AU Mitchell, P
Mottron, L
Soulieres, I
Ropar, D
AF Mitchell, Peter
Mottron, Laurent
Soulieres, Isabelle
Ropar, Danielle
TI Susceptibility to the Shepard Illusion in Participants with Autism:
Reduced Top-Down Influences Within Perception?
SO AUTISM RESEARCH
LA English
DT Article
DE low-level perception; visual illusion; 3D perception
ID PRIOR KNOWLEDGE; LOCAL BIAS; INDIVIDUALS; CHILDREN; PERFORMANCE;
ABILITIES; DEFICIT; TASKS
AB Previous research [Ropar & Mitchell, 2002] has shown that autistic individuals are somewhat immune to biases induced by top-down processes, particularly the influence of previous knowledge on perception. In order to test this hypothesis within perception, 18 participants with autism who had measured intelligence in the normal range were compared against 18 matched controls in their susceptibility to the Shepard illusion. The illusion consists in misperceiving the shape of a parallelogram in the presence of depth cues. It is attributed [Mitchell, Ropar, Ackroyd, & Rajendran, 2005] to the effect of top-down constraints within perception. The task involved adjusting a stimulus to the dimensions of a template on a computer screen. Both groups were susceptible to the illusion and the illusion effect was stronger when three-dimensional perspective cues were prominent. Notably, participants with autism were less susceptible to the illusion than typically developing individuals. The findings raise the possibility that in some instances top-down influences are attenuated in individuals with autism.
C1 [Mitchell, Peter; Ropar, Danielle] Univ Nottingham, Sch Psychol, Nottingham NG7 2RD, England.
[Mottron, Laurent; Soulieres, Isabelle] CETEDUM, Montreal, PQ, Canada.
[Mottron, Laurent; Soulieres, Isabelle] Univ Montreal, Dept Psychiat, Montreal, PQ H3C 3J7, Canada.
RP Mitchell, P (reprint author), Univ Nottingham, Sch Psychol, Univ Pk, Nottingham NG7 2RD, England.
EM peter.mitchell@nottingham.edu.my
FU Canadian Institutes for Health Research [MOP-84243]
FX Grant sponsor: Canadian Institutes for Health Research; Grant number:
MOP-84243.
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NR 27
TC 14
Z9 14
PU JOHN WILEY & SONS INC
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 1939-3792
J9 AUTISM RES
JI Autism Res.
PD JUN
PY 2010
VL 3
IS 3
BP 113
EP 119
DI 10.1002/aur.130
PG 7
WC Behavioral Sciences; Psychology, Developmental
SC Behavioral Sciences; Psychology
GA 620NV
UT WOS:000279507500002
PM 20575110
ER
PT J
AU Mazefsky, CA
Conner, CM
Oswald, DP
AF Mazefsky, Carla A.
Conner, Caitlin M.
Oswald, Donald P.
TI Association Between Depression and Anxiety in High-Functioning Children
with Autism Spectrum Disorders and Maternal Mood Symptoms
SO AUTISM RESEARCH
LA English
DT Article
DE autism; Asperger's disorder; psychiatric comorbidity; anxiety;
depression; mood disorders; familial aggregation; maternal symptoms
ID PERVASIVE DEVELOPMENTAL DISORDERS; PSYCHIATRIC-DISORDERS;
FAMILY-HISTORY; GENETIC EPIDEMIOLOGY; ASPERGER-SYNDROME; INDIVIDUALS;
SCL-90-R; ADULTS; METAANALYSIS; INTERVIEW
AB Research suggests that children with autism spectrum disorders (ASDs) and their relatives have high rates of depression and anxiety. However, relatively few studies have looked at both factors concurrently. This study examined the potential relationship between maternal mood symptoms and depression and anxiety in their children with ASD. Participants were 31 10- to 17-year-old children with an ASD diagnosis that was supported by gold-standard measures and their biological mothers. Mothers completed the Autism Comorbidity Interview to determine whether the child with ASD met criteria for any depressive or anxiety diagnoses and a questionnaire of their own current mood symptoms. As expected, many children with ASD met criteria for lifetime diagnoses of depressive (32%) and anxiety disorders (39%). Mothers' report of their own current mood symptoms revealed averages within the normal range, though there was significant variability. Approximately 75% of children with ASD could be correctly classified as having a depressive or anxiety disorder history or not based on maternal symptoms of interpersonal sensitivity, hostility, phobic anxiety, depression, and anxiety. The results provide preliminary evidence that maternal mood symptoms may be related to depression and anxiety in their children with ASD. Although the design did not allow for testing of heritability per se, the familial transmission patterns were generally consistent with research in typical populations. While larger follow-up studies are needed, this research has implications for prevention and intervention efforts.
C1 [Mazefsky, Carla A.; Conner, Caitlin M.] Univ Pittsburgh, Dept Psychiat, Pittsburgh, PA 15213 USA.
[Oswald, Donald P.] Virginia Commonwealth Univ, Dept Psychiat, Richmond, VA USA.
RP Mazefsky, CA (reprint author), Univ Pittsburgh, Dept Psychiat, Webster Hall Suite 300,3811 OHara St, Pittsburgh, PA 15213 USA.
EM mazefskyca@upmc.edu
FU Organization for Autism Research
FX Grant sponsor: Organization for Autism Research.
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
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NR 34
TC 23
Z9 24
PU JOHN WILEY & SONS INC
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 1939-3792
J9 AUTISM RES
JI Autism Res.
PD JUN
PY 2010
VL 3
IS 3
BP 120
EP 127
DI 10.1002/aur.133
PG 8
WC Behavioral Sciences; Psychology, Developmental
SC Behavioral Sciences; Psychology
GA 620NV
UT WOS:000279507500003
PM 20578069
ER
PT J
AU Falter, CM
Grant, KCP
Davis, G
AF Falter, Christine M.
Grant, Kate C. Plaisted
Davis, Greg
TI Object-Based Attention Benefits Reveal Selective Abnormalities of Visual
Integration in Autism
SO AUTISM RESEARCH
LA English
DT Article
DE autism; Gestalt; grouping; top-down
ID GLOBAL PRECEDENCE; LOCAL PRECEDENCE; CHILDREN; INDIVIDUALS; PERCEPTION;
DISORDERS; TASK
AB A pervasive integration deficit could provide a powerful and elegant account of cognitive processing in autism spectrum disorders (ASD). However, in the case of visual Gestalt grouping, typically assessed by tasks that require participants explicitly to introspect on their own grouping perception, clear evidence for such a deficit remains elusive. To resolve this issue, we adopt an index of Gestalt grouping from the object-based attention literature that does not require participants to assess their own grouping perception. Children with ASD and mental- and chronological-age matched typically developing children (TD) performed speeded orientation discriminations of two diagonal lines. The lines were superimposed on circles that were either grouped together or segmented on the basis of color, proximity or these two dimensions in competition. The magnitude of performance benefits evident for grouped circles, relative to ungrouped circles, provided an index of grouping under various conditions. Children with ASD showed comparable grouping by proximity to the TO group, but reduced grouping by similarity. ASD seems characterized by a selective bias away from grouping by similarity combined with typical levels of grouping by proximity, rather than by a pervasive integration deficit.
C1 [Falter, Christine M.] Univ Oxford, Warneford Hosp, Dept Psychiat, Oxford OX3 7JX, England.
[Grant, Kate C. Plaisted; Davis, Greg] Univ Cambridge, Dept Expt Psychol, Cambridge CB2 3EB, England.
RP Falter, CM (reprint author), Univ Oxford, Warneford Hosp, Dept Psychiat, Oxford OX3 7JX, England.
EM christine.falter@psych.ox.ac.uk; gjd1000@cam.ac.uk
RI Davis, Gregory/G-9954-2012
FU German National Academic Foundation
FX Grant sponsor: German National Academic Foundation.
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
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NR 30
TC 9
Z9 9
PU JOHN WILEY & SONS INC
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 1939-3792
J9 AUTISM RES
JI Autism Res.
PD JUN
PY 2010
VL 3
IS 3
BP 128
EP 136
DI 10.1002/aur.134
PG 9
WC Behavioral Sciences; Psychology, Developmental
SC Behavioral Sciences; Psychology
GA 620NV
UT WOS:000279507500004
PM 20578070
ER
PT J
AU McBride, KL
Varga, EA
Pastore, MT
Prior, TW
Manickam, K
Atkin, JF
Herman, GE
AF McBride, Kim L.
Varga, Elizabeth A.
Pastore, Matthew T.
Prior, Thomas W.
Manickam, Kandamurugu
Atkin, Joan F.
Herman, Gail E.
TI Confirmation Study of PTEN Mutations Among Individuals with Autism or
Developmental Delays/Mental Retardation and Macrocephaly
SO AUTISM RESEARCH
LA English
DT Article
DE genetic; Cowden syndrome; molecular genetics; PTEN; cancer; autism;
developmental delay
ID RILEY-RUVALCABA-SYNDROME; SPECTRUM DISORDERS; TUMOR-SUPPRESSOR;
COWDEN-SYNDROME; PREVALENCE; GENETICS; PHOSPHATASE; PROTEIN; FAMILY
AB There is a strong genetic component to autism spectrum disorders (ASD), but due to significant genetic heterogeneity, individual genetic abnormalities contribute a small percentage to the overall total. Previous studies have demonstrated PTEN mutations in a sizable proportion of individuals with ASD or mental retardation/developmental delays (MR/DD) and macrocephaly that do not have features of Cowden or Bannayan-Riley-Ruvalcaba syndrome. This study was performed to confirm our previous results. We reviewed the charts of individuals who had PTEN clinical sequencing performed at our institution from January 2008 to July 2009. There were 93 subjects tested from our institution during that period. PTEN mutations were found in 2/39 (5.1%) ASD patients and 2/51 (3.9%) MR/DD patients. Three additional patients without mutations had no diagnostic information. Multiple relatives of individuals with a PTEN mutation had macrocephaly, MR, or early onset cancer (breast, renal, and prostate). Of those relatives tested, all had the familial PTEN mutation. None of the affected relatives had previously been diagnosed with Cowden or Bannayan-Riley-Ruvalcaba syndrome. We noted in our previous study several adult relatives without any findings who puled a mutation. Combined with data from our previous cohort, we have found PTEN mutations in 7/99 (7.1%) of individuals with ASD and 8/100 (8.0%) of individuals with MR/DD, all of whom had macrocephaly. We recommend testing for mutations in PTEN for individuals with ASD or MR/DD and macrocephaly. If mutations are found, other family Members should be offered testing and the adults offered cancer screening if they have a PTEN mutation.
C1 [McBride, Kim L.; Varga, Elizabeth A.; Herman, Gail E.] Nationwide Childrens Hosp, Res Inst, Ctr Mol & Human Genet, Columbus, OH 43205 USA.
[McBride, Kim L.; Varga, Elizabeth A.; Pastore, Matthew T.; Manickam, Kandamurugu; Atkin, Joan F.; Herman, Gail E.] Ohio State Univ, Coll Med, Dept Pediat, Columbus, OH 43210 USA.
[Prior, Thomas W.] Ohio State Univ, Coll Med, Dept Pathol, Columbus, OH 43210 USA.
RP McBride, KL (reprint author), Nationwide Childrens Hosp, Res Inst, Ctr Mol & Human Genet, 700 Childrens Dr, Columbus, OH 43205 USA.
EM Kim.McBride@NationwideChildrens.org
RI Pastore, Matthew/B-6867-2012; Manickam, Kandamurugu/E-3585-2011;
McBride, Kim/A-5879-2008
OI McBride, Kim/0000-0002-8407-8942
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NR 25
TC 58
Z9 58
PU JOHN WILEY & SONS INC
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 1939-3792
J9 AUTISM RES
JI Autism Res.
PD JUN
PY 2010
VL 3
IS 3
BP 137
EP 141
DI 10.1002/aur.132
PG 5
WC Behavioral Sciences; Psychology, Developmental
SC Behavioral Sciences; Psychology
GA 620NV
UT WOS:000279507500005
PM 20533527
ER
PT J
AU Cook, EH
AF Cook, Edwin H., Jr.
TI Clinical Genetic Microarray Testing; ASD Neuropathology
SO AUTISM RESEARCH
LA English
DT Review
ID AUTISM SPECTRUM DISORDERS
C1 Univ Illinois, Dept Psychiat, Inst Juvenile Res, Chicago, IL 60608 USA.
RP Cook, EH (reprint author), Univ Illinois, Dept Psychiat, Inst Juvenile Res, Chicago, IL 60608 USA.
EM ecook@psych.uic.edu
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WEGIEL J, ACTA NEUROPATHOLOGY
NR 6
TC 0
Z9 0
PU JOHN WILEY & SONS INC
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 1939-3792
J9 AUTISM RES
JI Autism Res.
PD JUN
PY 2010
VL 3
IS 3
BP 142
EP 143
DI 10.1002/aur.140
PG 2
WC Behavioral Sciences; Psychology, Developmental
SC Behavioral Sciences; Psychology
GA 620NV
UT WOS:000279507500006
ER
PT J
AU Palmieri, L
Persico, AM
AF Palmieri, Luigi
Persico, Antonio M.
TI Mitochondrial dysfunction in autism spectrum disorders: Cause or effect?
SO BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
LA English
DT Article; Proceedings Paper
CT 16th European Bioenergetics Conference
CY JUL 17-22, 2010
CL Warsaw, POLAND
DE Autism; Mitochondria; Aspartate-glutamate carrier; Calcium signalling;
Oxidative stress; Immune dysfunction
ID PROTEIN-KINASE-C; INCREASED OXIDATIVE STRESS; CARRIER SLC25A12 GENE;
METABOLIC BIOMARKERS; DIETARY INTERVENTION; GLUTAMATE CARRIER;
ENERGY-METABOLISM; DIABETIC-RATS; CHILDREN; EXPRESSION
AB Autism Spectrum Disorders encompass severe developmental disorders characterized by variable degrees of impairment in language, communication and social skills, as well as by repetitive and stereotypic patterns of behaviour. Substantial percentages of autistic patients display peripheral markers of mitochondrial energy metabolism dysfunction, such as (a) elevated lactate, pyruvate, and alanine levels in blood, urine and/or cerebrospinal fluid, (b) serum carnitine deficiency, and/or (c) enhanced oxidative stress. These biochemical abnormalities are accompanied by highly heterogeneous clinical presentations, which generally (but by no means always) encompass neurological and systemic symptoms relatively unusual in idiopathic autistic disorder. In some patients, these abnormalities have been successfully explained by the presence of specific mutations or rearrangements in their mitochondrial or nuclear DNA. However, in the majority of cases, abnormal energy metabolism cannot be immediately linked to specific genetic or genomic defects. Recent evidence from post-mortem studies of autistic brains points toward abnormalities in mitochondrial function as possible downstream consequences of dysreactive immunity and altered calcium (Ca(2+)) signalling. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Palmieri, Luigi] Univ Bari, Dept Pharmacobiol, Biochem & Mol Biol Lab, I-70125 Bari, Italy.
[Palmieri, Luigi] Inst Biomembranes & Bioenerget, CNR, Bari, Italy.
[Persico, Antonio M.] Univ Campus Biomed, Lab Mol Psychiat & Neurogenet, Rome, Italy.
[Persico, Antonio M.] IRCCS Fdn Santa Lucia, Dept Expt Neurosci, Rome, Italy.
RP Palmieri, L (reprint author), Univ Bari, Dept Pharmacobiol, Biochem & Mol Biol Lab, Via Orabona 4, I-70125 Bari, Italy.
EM lpalm@farmbiol.uniba.it; a.persico@unicampus.it
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NR 86
TC 50
Z9 50
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0005-2728
J9 BBA-BIOENERGETICS
JI Biochim. Biophys. Acta-Bioenerg.
PD JUN-JUL
PY 2010
VL 1797
IS 6-7
BP 1130
EP 1137
DI 10.1016/j.bbabio.2010.04.018
PG 8
WC Biochemistry & Molecular Biology; Biophysics
SC Biochemistry & Molecular Biology; Biophysics
GA 622KV
UT WOS:000279663200064
PM 20441769
ER
PT J
AU Yorbik, O
Kurt, I
Hasimi, A
Ozturk, O
AF Yorbik, Oezguer
Kurt, Ismail
Hasimi, Adnan
Ozturk, Ozlem
TI Chromium, Cadmium, and Lead Levels in Urine of Children with Autism and
Typically Developing Controls
SO BIOLOGICAL TRACE ELEMENT RESEARCH
LA English
DT Article
DE Autism; Chromium; Cadmium; Lead; Heavy metals; Trace elements
ID OXIDATIVE STRESS; LIPID-PEROXIDATION; TOXIC METALS; HAIR;
TRANSSULFURATION; GLUTATHIONE; BIOMARKERS; DISORDERS; EXCRETION;
APOPTOSIS
AB Although potentially harmful effects of heavy metals are well known, limited numbers of studies exist regarding their relationship with autism. The aim of this study was to investigate urine levels of some heavy metals such as of chromium (Cr), cadmium (Cd), and lead (Pb) in children with autism and healthy subjects. Urine levels of Cr, Cd, and Pb were measured by atomic absorption spectrometry in 30 children with autism and compared with 20 healthy controls. Urine Cd and Pb levels were found as significantly decreased in children with autism compared to healthy subjects (p < 0.05). On the other hand, urine Cr levels were significantly higher in children with autism than healthy subjects (p < 0.05). This study suggested that autism may be associated with significant decrease in excretion rate of Cd and Pb and a significant increase excretion rate in the levels of Cr in the urine. These results have indicated that further studies are warranted for investigation of possible roles of heavy metals in autism.
C1 [Yorbik, Oezguer] Gulhane Mil Med Fac, Child Psychiat Dept, TR-06018 Ankara, Turkey.
[Kurt, Ismail; Hasimi, Adnan; Ozturk, Ozlem] Gulhane Mil Med Fac, Dept Biochem, TR-06018 Ankara, Turkey.
RP Yorbik, O (reprint author), Gulhane Mil Med Fac, Child Psychiat Dept, TR-06018 Ankara, Turkey.
EM oyorbik@yahoo.com
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NR 37
TC 16
Z9 16
PU HUMANA PRESS INC
PI TOTOWA
PA 999 RIVERVIEW DRIVE SUITE 208, TOTOWA, NJ 07512 USA
SN 0163-4984
J9 BIOL TRACE ELEM RES
JI Biol. Trace Elem. Res.
PD JUN
PY 2010
VL 135
IS 1-3
BP 10
EP 15
DI 10.1007/s12011-009-8494-7
PG 6
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA 590LM
UT WOS:000277227600002
PM 19688188
ER
PT J
AU Gold, R
Faust, M
Goldstein, A
AF Gold, Rinat
Faust, Miriam
Goldstein, Abraham
TI Semantic integration during metaphor comprehension in Asperger syndrome
SO BRAIN AND LANGUAGE
LA English
DT Article
DE Asperger syndrome; Semantic integration; Metaphor comprehension; Event
related potentials; N400
ID HIGH-FUNCTIONING ADULTS; RIGHT CEREBRAL HEMISPHERE; EVENT-RELATED
POTENTIALS; LEXICAL DECISION; AUTISM; CHILDREN; LANGUAGE; EXPRESSIONS;
FMRI; DISORDERS
AB Previous research indicates severe disabilities in processing figurative language in people diagnosed on the autism spectrum disorders. However, this aspect of language comprehension in Asperger syndrome (AS) specifically has rarely been the subject of formal study. The present study aimed to examine the possibility that in addition to their pragmatic deficits, the difficulties in the comprehension of metaphors in AS may be explained by deficient linguistic information processing. Specifically, we aimed to examine whether a deficient semantic integration process underlies the difficulties in metaphor comprehension frequently experienced by persons with AS. The semantic integration process of sixteen AS participants and sixteen matched controls was examined using event related potentials (ERPs). N400 amplitude served as an index for degree of effort invested in the semantic integration process of two-word expressions denoting literal, conventional metaphoric, and novel metaphoric meaning, as well as unrelated word pairs. Large N400 amplitudes for both novel and conventional metaphors demonstrated the greater difficulties in metaphor comprehension in the AS participants as compared to controls. Findings suggest that differences in linguistic information processing cause difficulties in metaphor comprehension in AS. (C) 2010 Elsevier Inc. All rights reserved.
C1 [Faust, Miriam] Bar Ilan Univ, Dept Psychol, IL-52900 Ramat Gan, Israel.
[Gold, Rinat; Faust, Miriam; Goldstein, Abraham] Bar Ilan Univ, Leslie & Susan Gonda Goldschmied Multidisciplinar, IL-52900 Ramat Gan, Israel.
RP Faust, M (reprint author), Bar Ilan Univ, Dept Psychol, IL-52900 Ramat Gan, Israel.
EM faustm@mail.biu.ac.il
FU Israel Science Foundation (ISF) [724/09]
FX The authors thank the Asperger syndrome research participants and their
families for their cooperation and interest in this study. The authors
thank the Israel Asperger Syndrome Association and Beit Ekstein
organization for their assistance in recruiting the Asperger syndrome
participants. The authors thank Chen Kleiman for his useful assistance
in conducting the experiments.This study was performed in partial
fulfillment of the requirements for the first author's doctoral
dissertation at Bar-Ilan University.This research was supported by the
Israel Science Foundation (ISF) grant (number 724/09) to Miriam Faust.
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NR 53
TC 24
Z9 24
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0093-934X
J9 BRAIN LANG
JI Brain Lang.
PD JUN
PY 2010
VL 113
IS 3
BP 124
EP 134
DI 10.1016/j.band1.2010.03.002
PG 11
WC Audiology & Speech-Language Pathology; Linguistics; Neurosciences;
Psychology, Experimental
SC Audiology & Speech-Language Pathology; Linguistics; Neurosciences &
Neurology; Psychology
GA 594PC
UT WOS:000277548600003
PM 20359737
ER
PT J
AU Rahko, J
Paakki, JJ
Starck, T
Nikkinen, J
Remes, J
Hurtig, T
Kuusikko-Gauffin, S
Mattila, ML
Jussila, K
Jansson-Verkasalo, E
Katsyri, J
Sams, M
Pauls, D
Ebeling, H
Moilanen, I
Tervonen, O
Kiviniemi, V
AF Rahko, Jukka
Paakki, Jyri-Johan
Starck, Tuomo
Nikkinen, Juha
Remes, Jukka
Hurtig, Tuula
Kuusikko-Gauffin, Sanna
Mattila, Marja-Leena
Jussila, Katja
Jansson-Verkasalo, Eira
Katsyri, Jari
Sams, Mikko
Pauls, David
Ebeling, Hanna
Moilanen, Irma
Tervonen, Osmo
Kiviniemi, Vesa
TI Functional Mapping of Dynamic Happy and Fearful Facial Expression
Processing in Adolescents
SO BRAIN IMAGING AND BEHAVIOR
LA English
DT Article
DE Adolescent; Arousal; Basic emotion; Emotional facial expressions;
Emotion recognition; Emotional and social interaction; Face processing;
Mirror neuron system; Theory of mind; Typical development; Valence;
Visual perception
ID MIRROR-NEURON SYSTEM; AUTISM SPECTRUM DISORDERS; SCHOOL-AGE-CHILDREN;
ASPERGER-SYNDROME; HUMAN BRAIN; EMOTION PERCEPTION; FACE PERCEPTION;
FMRI; RECOGNITION; AMYGDALA
AB This paper assessed the neural systems involved in processing of dynamic facial expressions in adolescents. The processing of facial expressions changes as a function of age, and it is thus important to understand how healthy adolescent subjects process dynamic facial expressions prior to analyzing disease-related changes. We hypothesized that viewing of dynamic facial expressions with opposing valences (happy vs. fearful) induces differential activations and deactivations in the brain. 27 healthy adolescents (9 a (TM) Euro, 18 a (TM),, mean age = 14.5 years; age range 11.6-17.3 years) were examined by using the ASSQ and K-SADS-PL and scanned with 1.5-T fMRI during viewing of dynamic facial expressions and mosaic control images. The stimuli activated the same areas as previously seen in dynamic facial expression in adults. Our results indicated that opposing-valence dynamic facial expressions had differential effects on many cortical structures but not on subcortical limbic structures. The mirror neuron system is activated more during viewing of fearful compared to happy expressions in bilateral inferior frontal gyrus (IFG) and superior temporal sulcus (STS) left dominantly. We also detected more deactivation in the ventral anterior cingulate gyrus (ACG), showing more automated attentional processing of fearful expressions during passive viewing. Females were found to deactivate the right frontal pole more than male adolescents during happy facial expressions, while there were no differences in fear processing between genders. No clear gender or age effects were detected. In conclusion fear induces stronger responses in attention and mirror neurons probably related to fear contagion.
C1 [Rahko, Jukka; Kuusikko-Gauffin, Sanna; Mattila, Marja-Leena; Jussila, Katja; Ebeling, Hanna; Moilanen, Irma] Univ Oulu, Dept Child Psychiat, Oulu 90029, Finland.
[Rahko, Jukka; Paakki, Jyri-Johan; Starck, Tuomo; Nikkinen, Juha; Remes, Jukka; Kuusikko-Gauffin, Sanna; Mattila, Marja-Leena; Jussila, Katja; Ebeling, Hanna; Moilanen, Irma; Tervonen, Osmo; Kiviniemi, Vesa] Univ Hosp Oulu, Oulu 90029, Finland.
[Paakki, Jyri-Johan; Starck, Tuomo; Nikkinen, Juha; Remes, Jukka; Tervonen, Osmo; Kiviniemi, Vesa] Univ Oulu, Dept Diagnost Radiol, Oulu 90029, Finland.
[Hurtig, Tuula] Univ Oulu, Inst Hlth Sci, Oulu 90029, Finland.
[Hurtig, Tuula] Univ Oulu, Clin Child Psychiat, Oulu 90029, Finland.
[Jansson-Verkasalo, Eira] Univ Hosp Oulu, Dept Clin Neurophysiol, Oulu, Finland.
[Katsyri, Jari; Sams, Mikko] Aalto Univ, Sch Sci & Technol, Dept Biomed Engn & Computat Sci, Helsinki, Finland.
[Pauls, David] Massachusetts Gen Hosp Harvard Med Sch, Ctr Human Genet Res, Psychiat & Neurodev Genet Unit, Oulu, Finland.
RP Rahko, J (reprint author), Univ Oulu, Dept Child Psychiat, POB 26, Oulu 90029, Finland.
EM Jukka.Rahko@oulu.fi; jpaakki@mail.student.oulu.fi; tstarck@paju.oulu.fi;
juha.nikkinen@oulu.fi; jjremes@ee.oulu.fi; tuula.hurtig@oulu.fi;
sanna.kuusikkogauffin@gmail.com; marja-leena.mattila@fimnet.fi;
katja.jussila@oulu.fi; Hanna.Ebeling@ppshp.fi; Irma.Moilanen@oulu.fi;
Osmo.Tervonen@ppshp.fi; Vesa.Kiviniemi@oulu.fi
RI Sams, Mikko/G-7060-2012; Frank, David/E-8213-2012; Remes,
Jukka/E-4217-2015
OI Remes, Jukka/0000-0003-1685-8346
FU Alma and K.A. Snellman Foundation, Oulu, Finland; Emil Aaltonen
Foundation, Finland; Sigrid Juselius Foundation, Finland; Thule
Institute, Oulu, Finland; Finnish Academy [117111]; Finnish Medical
Foundation; Graduate School of Circumpolar Wellbeing Health and
Adaptation
FX We wish to thank the adolescents and their families for participating.
This study received financial support from the Alma and K.A. Snellman
Foundation, Oulu, Finland, the Emil Aaltonen Foundation, Finland, the
Sigrid Juselius Foundation, Finland and the Thule Institute, Oulu,
Finland. This study was funded by Finnish Academy Grant # 117111 and
Finnish Medical Foundation grants. The Graduate School of Circumpolar
Wellbeing Health and Adaptation is acknowledged for their support.
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NR 78
TC 18
Z9 19
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1931-7557
J9 BRAIN IMAGING BEHAV
JI Brain Imaging Behav.
PD JUN
PY 2010
VL 4
IS 2
BP 164
EP 176
DI 10.1007/s11682-010-9096-x
PG 13
WC Neuroimaging
SC Neurosciences & Neurology
GA 606HJ
UT WOS:000278413200005
PM 20502991
ER
PT J
AU Narayanan, A
White, CA
Saklayen, S
Scaduto, MJ
Carpenter, AL
Abduljalil, A
Schmalbrock, P
Beversdorf, DQ
AF Narayanan, Ananth
White, Catherine A.
Saklayen, Sanjida
Scaduto, Mary J.
Carpenter, Allen L.
Abduljalil, Amir
Schmalbrock, Petra
Beversdorf, David Q.
TI Effect of Propranolol on Functional Connectivity in Autism Spectrum
Disorder-A Pilot Study
SO BRAIN IMAGING AND BEHAVIOR
LA English
DT Article
DE Autism; Functional connectivity; Noradrenergic; Language; Propranolol;
Asperger syndrome
ID WORKING-MEMORY PERFORMANCE; BETA-ADRENERGIC MODULATION; COGNITIVE
FLEXIBILITY; NORADRENERGIC MODULATION; INFANTILE-AUTISM; CHILDREN;
LANGUAGE; ADULTS; MIND; INDIVIDUALS
AB A decrease in interaction between brain regions is observed in individuals with autism spectrum disorder (ASD), which is believed to be related to restricted neural network access in ASD. Propranolol, a beta-adrenergic antagonist, has revealed benefit during performance of tasks involving flexibility of access to networks, a benefit also seen in ASD. Our goal was to determine the effect of propranolol on functional connectivity in ASD during a verbal decision making task as compared to nadolol, thereby accounting for the potential spurious fMRI effects due to peripheral hemodynamic effects of propranolol. Ten ASD subjects underwent fMRI scans after administration of placebo, propranolol or nadolol, while performing a phonological decision making task. Comparison of functional connectivity between pre-defined ROI-pairs revealed a significant increase with propranolol compared to nadolol, suggesting a potential imaging marker for the cognitive effects of propranolol in ASD.
C1 [Narayanan, Ananth; Saklayen, Sanjida; Beversdorf, David Q.] Univ Missouri, Dept Radiol, Thompson Ctr, Columbia, MO 65211 USA.
[White, Catherine A.] Ohio State Univ, Dept Psychiat, Columbus, OH 43210 USA.
[White, Catherine A.] Ohio State Univ, Dept Neurol, Columbus, OH 43210 USA.
[Saklayen, Sanjida; Scaduto, Mary J.] Ohio State Univ, Coll Med, Columbus, OH 43210 USA.
[Carpenter, Allen L.] Ohio State Univ, Neurosci Grad Studies Program, Columbus, OH 43210 USA.
[Abduljalil, Amir; Schmalbrock, Petra] Ohio State Univ, Dept Radiol, Columbus, OH 43210 USA.
[Beversdorf, David Q.] Univ Missouri, Dept Neurol, Columbia, MO USA.
[Beversdorf, David Q.] Univ Missouri, Dept Psychol, Columbia, MO USA.
RP Beversdorf, DQ (reprint author), Univ Missouri, Dept Radiol, Thompson Ctr, 300 Portland St,Suite 122, Columbia, MO 65211 USA.
EM beversdorfd@health.missouri.edu
FU National Alliance for Autism Research [1033/DB//01-201-005-00-00]; NINDS
[K23 NS43222]; The Ohio State University Medical Center Research
Investment Fund; Wright Center for Innovation; University of Missouri
Department of Radiology Research Investment Fund
FX This research is funded through a pilot grant from National Alliance for
Autism Research (now Autism Speaks) (1033/DB//01-201-005-00-00), grants
from NINDS (K23 NS43222), The Ohio State University Medical Center
Research Investment Fund and the Wright Center for Innovation, and by
the University of Missouri Department of Radiology Research Investment
Fund. We would like to thank Bradley Ferguson for his help with the
manuscript.
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NR 46
TC 12
Z9 12
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1931-7557
J9 BRAIN IMAGING BEHAV
JI Brain Imaging Behav.
PD JUN
PY 2010
VL 4
IS 2
BP 189
EP 197
DI 10.1007/s11682-010-9098-8
PG 9
WC Neuroimaging
SC Neurosciences & Neurology
GA 606HJ
UT WOS:000278413200007
PM 20502989
ER
PT J
AU Jarrold, C
Mansergh, R
Whiting, C
AF Jarrold, Christopher
Mansergh, Ruth
Whiting, Claire
TI The representational status of pretence: Evidence from typical
development and autism
SO BRITISH JOURNAL OF DEVELOPMENTAL PSYCHOLOGY
LA English
DT Article
ID BEHAVING-AS-IF; INDIVIDUAL-DIFFERENCES; VERBAL-ABILITY; YOUNG-CHILDREN;
MIND; PLAY; BELIEFS; UNDERPINNINGS; COMPREHENSION; TODDLERS
AB The question of whether understanding pretend play requires meta-representational skill was examined among typically developing children and individuals with autism. Participants were presented with closely equated true and false pretence trials in which they had to judge a protagonist's pretend reading of a situation, which either matched or differed from their own. Results showed that individuals' theory of mind abilities determined their performance on false, but not true, pretence trials. These findings imply that meta-representation is involved when an individual has to make sense of a pretend state of mind that differs from their own, but, crucially, they also show that pretend play can often be understood without meta-representational competence.
C1 [Jarrold, Christopher] Univ Bristol, Dept Expt Psychol, Bristol BS8 1TU, Avon, England.
RP Jarrold, C (reprint author), Univ Bristol, Dept Expt Psychol, Bristol BS8 1TU, Avon, England.
EM C.Jarrold@bristol.ac.uk
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NR 51
TC 3
Z9 3
PU BRITISH PSYCHOLOGICAL SOC
PI LEICESTER
PA ST ANDREWS HOUSE, 48 PRINCESS RD EAST, LEICESTER LE1 7DR, LEICS, ENGLAND
SN 0261-510X
J9 BRIT J DEV PSYCHOL
JI Br. J. Dev. Psychol.
PD JUN
PY 2010
VL 28
IS 2
BP 239
EP 254
DI 10.1348/026151008X400085
PG 16
WC Psychology, Developmental
SC Psychology
GA 605CT
UT WOS:000278325700002
PM 20481386
ER
PT J
AU Holland, L
Low, J
AF Holland, Lucy
Low, Jason
TI Do children with autism use inner speech and visuospatial resources for
the service of executive control? Evidence from suppression in dual
tasks
SO BRITISH JOURNAL OF DEVELOPMENTAL PSYCHOLOGY
LA English
DT Article
ID SHORT-TERM-MEMORY; WORKING-MEMORY; SPECTRUM DISORDERS; PRIVATE SPEECH;
INTACT; DYSFUNCTION; PRESCHOOLERS; PERFORMANCE; DIFFICULTY; CAPACITY
AB Three experiments used dual-task suppression methodology to study the use of inner speech and visuospatial resources for mediating central executive performance by children with autism (CWA) and group-matched typically developing (TD) controls. Expt 1 revealed that CWA did not recruit inner speech to facilitate arithmetic task-switching performance: there was no effect of articulatory suppression (AS) on completion time for CWA compared to the TD group. Expt 2 revealed that suppression of visuospatial resources disrupted the task-switching performance of both CWA and TD groups. It also confirmed that the task-switching performance of CWA was significantly slowed by visuospatial compared to AS. Expt 3 showed that CWA also did not employ inner speech, compared to visuospatial resources, for implementing planning movements. Overall, compared to the mixture of representations used by the TD group for problem solving, CWA seemed to use visuospatial working memory resources but not inner speech to service executive control.
C1 [Holland, Lucy; Low, Jason] Victoria Univ Wellington, Sch Psychol, Wellington 6140, New Zealand.
RP Low, J (reprint author), Victoria Univ Wellington, Sch Psychol, POB 600, Wellington 6140, New Zealand.
EM Jason.Low@vuw.ac.nz
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NR 52
TC 8
Z9 8
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0261-510X
EI 2044-835X
J9 BRIT J DEV PSYCHOL
JI Br. J. Dev. Psychol.
PD JUN
PY 2010
VL 28
IS 2
BP 369
EP 391
DI 10.1348/026151009X424088
PG 23
WC Psychology, Developmental
SC Psychology
GA 605CT
UT WOS:000278325700009
PM 20481393
ER
PT J
AU Blampied, M
Johnston, L
Miles, L
Liberty, K
AF Blampied, Meredith
Johnston, Lucy
Miles, Lynden
Liberty, Kathleen
TI Sensitivity to differences between enjoyment and non-enjoyment smiles in
children with autism spectrum disorder
SO BRITISH JOURNAL OF DEVELOPMENTAL PSYCHOLOGY
LA English
DT Article
ID EMOTION; RECOGNITION; PEOPLE; FACES
AB The sensitivity of male children (5-15 years) with and without autism spectrum disorder (ASD) to the affective state of others was tested using an emotion recognition task. Only children without ASD could reliably differentiate between enjoyment and non-enjoyment smiles. Results are considered in terms of the social impairments of children with ASD.
C1 [Blampied, Meredith; Johnston, Lucy; Miles, Lynden] Univ Canterbury, Dept Psychol, Social Percept Lab, Christchurch 8020, New Zealand.
[Miles, Lynden] Univ Aberdeen, Sch Psychol, Aberdeen AB9 1FX, Scotland.
[Liberty, Kathleen] Univ Canterbury, Sch Educ Studies & Human Dev, Christchurch 8020, New Zealand.
RP Johnston, L (reprint author), Univ Canterbury, Dept Psychol, Social Percept Lab, Private Bag 4800, Christchurch 8020, New Zealand.
EM lucy.johnston@canterbury.ac.nz
RI Miles, Lynden/C-5168-2008
OI Miles, Lynden/0000-0002-4164-3470
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NR 31
TC 3
Z9 3
PU BRITISH PSYCHOLOGICAL SOC
PI LEICESTER
PA ST ANDREWS HOUSE, 48 PRINCESS RD EAST, LEICESTER LE1 7DR, LEICS, ENGLAND
SN 0261-510X
J9 BRIT J DEV PSYCHOL
JI Br. J. Dev. Psychol.
PD JUN
PY 2010
VL 28
IS 2
BP 483
EP 489
DI 10.1348/026151009X467621
PG 7
WC Psychology, Developmental
SC Psychology
GA 605CT
UT WOS:000278325700015
PM 20481399
ER
PT J
AU Craddock, N
Owen, MJ
AF Craddock, Nick
Owen, Michael J.
TI Revisiting Bleuler: relationship between autism and schizophrenia Reply
SO BRITISH JOURNAL OF PSYCHIATRY
LA English
DT Letter
C1 [Craddock, Nick; Owen, Michael J.] Cardiff Univ, Sch Med, MRC Ctr Neuropsychiat Genet & Genom, Cardiff CF14 4XN, S Glam, Wales.
RP Craddock, N (reprint author), Cardiff Univ, Sch Med, MRC Ctr Neuropsychiat Genet & Genom, Heath Pk, Cardiff CF14 4XN, S Glam, Wales.
EM craddockn@cardiff.ac.uk
RI turton, miranda/F-4682-2011
CR Craddock N, 2009, BRIT J PSYCHIAT, V195, P97, DOI 10.1192/bjp.bp.108.063156
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NR 5
TC 0
Z9 0
PU ROYAL COLLEGE OF PSYCHIATRISTS
PI LONDON
PA BRITISH JOURNAL OF PSYCHIATRY 17 BELGRAVE SQUARE, LONDON SW1X 8PG,
ENGLAND
SN 0007-1250
J9 BRIT J PSYCHIAT
JI Br. J. Psychiatry
PD JUN
PY 2010
VL 196
IS 6
BP 495
EP 496
DI 10.1192/bjp.196.6.495a
PG 2
WC Psychiatry
SC Psychiatry
GA 606LZ
UT WOS:000278427800016
ER
PT J
AU Crespi, BJ
AF Crespi, Bernard J.
TI Revisiting Bleuler: relationship between autism and schizophrenia
SO BRITISH JOURNAL OF PSYCHIATRY
LA English
DT Letter
C1 Simon Fraser Univ, Dept Biol Sci, Burnaby, BC V5A 1S6, Canada.
RP Crespi, BJ (reprint author), Simon Fraser Univ, Dept Biol Sci, 8888 Univ Dr, Burnaby, BC V5A 1S6, Canada.
EM crespi@sfu.ca
CR Craddock N, 2010, BRIT J PSYCHIAT, V196, P92, DOI 10.1192/bjp.bp.109.073429
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NR 5
TC 4
Z9 4
PU ROYAL COLLEGE OF PSYCHIATRISTS
PI LONDON
PA BRITISH JOURNAL OF PSYCHIATRY 17 BELGRAVE SQUARE, LONDON SW1X 8PG,
ENGLAND
SN 0007-1250
J9 BRIT J PSYCHIAT
JI Br. J. Psychiatry
PD JUN
PY 2010
VL 196
IS 6
BP 495
EP 495
DI 10.1192/bjp.196.6.495
PG 1
WC Psychiatry
SC Psychiatry
GA 606LZ
UT WOS:000278427800015
PM 20513864
ER
PT J
AU Bereiter, J
AF Bereiter, Jeanne
TI How to talk to parents about autism
SO BULLETIN OF THE MENNINGER CLINIC
LA English
DT Book Review
C1 [Bereiter, Jeanne] Univ New Mexico, Dept Psychiat, Albuquerque, NM 87131 USA.
RP Bereiter, J (reprint author), Univ New Mexico, Dept Psychiat, 1 UNM,MSC09-5030, Albuquerque, NM 87131 USA.
EM jbereiter@salud.unm.edu
CR SANDERS RQ, 2008, HOW PARENTS AUTISM
NR 1
TC 0
Z9 0
PU GUILFORD PUBLICATIONS INC
PI NEW YORK
PA 72 SPRING STREET, NEW YORK, NY 10012 USA
SN 0025-9284
J9 B MENNINGER CLIN
JI Bull. Menninger Clin.
PD SUM
PY 2010
VL 74
IS 3
BP 262
EP 262
PG 1
WC Psychiatry; Psychology, Psychoanalysis
SC Psychiatry; Psychology
GA 651HE
UT WOS:000281917700010
ER
PT J
AU Marion, K
AF Marion, Kim
TI The Autism Transition Guide: Planning The Journey From School To Adult
Life
SO CANADIAN JOURNAL OF OCCUPATIONAL THERAPY-REVUE CANADIENNE D ERGOTHERAPIE
LA English
DT Book Review
CR BRUEY CT, 2009, AUTISM TRANSITION GU
NR 1
TC 0
Z9 0
PU CANADIAN ASSOC OCCUPATIONAL THERAPISTS
PI OTTAWA
PA CTTC BLDG, 3400-1125 COLONEL BY DRIVE, OTTAWA, ONTARIO K1S 5R1, CANADA
SN 0008-4174
J9 CAN J OCCUP THER
JI Can. J. Occup. Ther.
PD JUN
PY 2010
VL 77
IS 3
BP 166
EP 166
PG 1
WC Rehabilitation
SC Rehabilitation
GA V20TQ
UT WOS:000208162700007
ER
PT J
AU Fujita, E
Dai, H
Tanabe, Y
Zhiling, Y
Yamagata, T
Miyakawa, T
Tanokura, M
Momoi, MY
Momoi, T
AF Fujita, E.
Dai, H.
Tanabe, Y.
Zhiling, Y.
Yamagata, T.
Miyakawa, T.
Tanokura, M.
Momoi, M. Y.
Momoi, T.
TI Autism spectrum disorder is related to endoplasmic reticulum stress
induced by mutations in the synaptic cell adhesion molecule, CADM1
SO CELL DEATH & DISEASE
LA English
DT Article
DE autism; Cadm1; ER stress
ID QUALITY-CONTROL; PROTEIN; NEUROLIGINS; MICE; EXPRESSION; PLASTICITY;
MEMORY; MODEL; GENE; CHOP
AB Autism spectrum disorder (ASD) is a neurodevelopmental disorder with an unknown molecular pathogenesis. A recent molecular focus has been the mutated neuroligin 3, neuroligin 3(R451C), in gain-of-function studies and for its role in induced impairment of synaptic function, but endoplasmic reticulum (ER) stress induced by mutated molecules also deserves investigation. We previously found two missense mutations, H246N and Y251S, in the gene-encoding synaptic cell adhesion molecule-1 (CADM1) in ASD patients, including cleavage of the mutated CADM1 and its intracellular accumulation. In this study, we found that the mutated CADM1 showed slightly reduced homophilic interactions in vitro but that most of its interactions persist. The mutated CADM1 also showed morphological abnormalities, including shorter dendrites, and impaired synaptogenesis in neurons. Wild-type CADM1 was partly localized to the ER of C2C5 cells, whereas mutated CADM1 mainly accumulated in the ER despite different sensitivities toward 4-phenyl butyric acid with chemical chaperone activity and rapamycin with promotion activity for degradation of the aggregated protein. Modeling analysis suggested a direct relationship between the mutations and the conformation alteration. Both mutated CADM1 and neuroligin 3(R451C) induced upregulation of C/EBP-homologous protein (CHOP), an ER stress marker, suggesting that in addition to the trafficking impairment, this CHOP upregulation may also be involved in ASD pathogenesis. Cell Death and Disease (2010) 1, e47; doi:10.1038/cddis.2010.23; published online 3 June 2010
C1 [Fujita, E.; Dai, H.; Tanabe, Y.; Momoi, T.] Natl Inst Neurosci, Div Differentiat & Dev, NCNP, Kodaira, Tokyo 1878502, Japan.
[Fujita, E.; Zhiling, Y.; Yamagata, T.; Momoi, M. Y.] Jichi Med Univ, Dept Pediat, Shimotsukeshi, Tochigi 3290498, Japan.
[Dai, H.; Tanabe, Y.; Momoi, T.] Int Univ Hlth & Welf, Ctr Med Sci, Ohtawara, Tochigi 3248501, Japan.
[Miyakawa, T.; Tanokura, M.] Univ Tokyo, Grad Sch Agr & Life Sci, Dept Appl Biol Chem, Bunkyo Ku, Tokyo 1138657, Japan.
RP Momoi, T (reprint author), Natl Inst Neurosci, Div Differentiat & Dev, NCNP, 4-1-1 Ogawahigashi Machi, Kodaira, Tokyo 1878502, Japan.
EM momoi@ncnp.go.jp
FU Autism Genetic Resource Exchange (AGRE) Consortium; National Institute
of Mental Health [1U24MH081810]; Japanese Ministry of Education,
Culture, Sports, Science and Technology [21200011, 21500334, 21700377];
Ministry of Health, Labor and Welfare [20B-13]; Japan Health Science
Foundation
FX We express our deepest sympathy at the untimely passing of an excellent
neuroscientist, Dr. Alaa El-Husseini. We gratefully acknowledge the
resources provided by the Autism Genetic Resource Exchange (AGRE)
Consortium and the participating AGRE families. AGRE is a program of
Autism Speaks and is supported, in part, by Grant 1U24MH081810 from the
National Institute of Mental Health to Clara M Lajonchere (PI). This
work was supported by grants from the Japanese Ministry of Education,
Culture, Sports, Science and Technology (21200011, 21500334, 21700377),
for research into nervous and mental disorders from the Ministry of
Health, Labor and Welfare (20B-13), for research on Publicly Essential
Drugs and Medical Devices from the Japan Health Science Foundation.
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NR 39
TC 21
Z9 21
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 2041-4889
J9 CELL DEATH DIS
JI Cell Death Dis.
PD JUN
PY 2010
VL 1
AR e47
DI 10.1038/cddis.2010.23
PG 7
WC Cell Biology
SC Cell Biology
GA 624LB
UT WOS:000279819000001
PM 21364653
ER
PT J
AU Juranek, J
Dennis, M
Cirino, PT
El-Messidi, L
Fletcher, JM
AF Juranek, Jenifer
Dennis, Maureen
Cirino, Paul T.
El-Messidi, Lyla
Fletcher, Jack M.
TI The Cerebellum in Children with Spina Bifida and Chiari II Malformation:
Quantitative Volumetrics by Region
SO CEREBELLUM
LA English
DT Article
DE Cerebellum; Volumetrics; Parcellation; Spina bifida; Chiari II
ID COGNITIVE-AFFECTIVE SYNDROME; VELOCARDIOFACIAL SYNDROME;
WILLIAMS-SYNDROME; MOTOR CORTEX; BRAIN IMAGES; NEURAL-TUBE; MR-IMAGES;
HYDROCEPHALUS; MYELOMENINGOCELE; AUTISM
AB Few volumetric MRI studies of the entire cerebellum have been published; even less quantitative information is available in patients with hindbrain malformations, including the Chiari II malformation which is ubiquitous in patients with spina bifida meningomyelocele (SBM). In the present study, regional volumetric analyses of the cerebellum were conducted in children with SBM/Chiari II and typically developing (TD) children. Total cerebellar volume was significantly reduced in the SBM group relative to the TD group. After correcting for total cerebellum volume, and relative to the TD group, the posterior lobe was significantly reduced in SBM, the corpus medullare was not different, and the anterior lobe was significantly enlarged. Children with thoracic level lesions had smaller cerebellar volumes relative to those with lumbar/sacral lesions, who had smaller volumes compared to TD children. The reduction in cerebellar volume in the group with SBM represents not a change in linear scaling but rather a reconfiguration involving anterior lobe enlargement and posterior lobe reduction.
C1 [Juranek, Jenifer] Univ Texas Hlth Sci Ctr Houston, Dept Pediat, Childrens Learning Inst, Houston, TX 77030 USA.
[Dennis, Maureen] Hosp Sick Children, Toronto, ON M5G 1X8, Canada.
[Cirino, Paul T.; El-Messidi, Lyla; Fletcher, Jack M.] Univ Houston, Dept Psychol, Houston, TX USA.
[Cirino, Paul T.] Univ Houston, Texas Inst Measurement Evaluat & Stat, Houston, TX USA.
RP Juranek, J (reprint author), Univ Texas Hlth Sci Ctr Houston, Dept Pediat, Childrens Learning Inst, 7000 Fannin,Ste 2411, Houston, TX 77030 USA.
EM Jenifer.Juranek@uth.tmc.edu
FU NIH [P01HD35946, R01-HD046609]
FX This work is funded by NIH grants P01HD35946 awarded to JMF and
R01-HD046609 awarded to Dr. Susan Landry.
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NR 57
TC 11
Z9 12
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1473-4222
J9 CEREBELLUM
JI Cerebellum
PD JUN
PY 2010
VL 9
IS 2
BP 240
EP 248
DI 10.1007/s12311-010-0157-x
PG 9
WC Neurosciences
SC Neurosciences & Neurology
GA 593JN
UT WOS:000277450100011
PM 20143197
ER
PT J
AU Raznahan, A
Toro, R
Daly, E
Robertson, D
Murphy, C
Deeley, Q
Bolton, PF
Paus, T
Murphy, DGM
AF Raznahan, Armin
Toro, Roberto
Daly, Eileen
Robertson, Dene
Murphy, Clodagh
Deeley, Quinton
Bolton, Patrick F.
Paus, Tomas
Murphy, Declan G. M.
TI Cortical Anatomy in Autism Spectrum Disorder: An In Vivo MRI Study on
the Effect of Age
SO CEREBRAL CORTEX
LA English
DT Article
DE age; autism; brain; cortical thickness; MRI
ID HUMAN CEREBRAL-CORTEX; BRAIN SIZE; HEAD CIRCUMFERENCE;
ASPERGERS-SYNDROME; LONGITUDINAL MRI; NEURAL CIRCUITRY; GRAY-MATTER;
CHILDREN; THICKNESS; GROWTH
AB There is increasing evidence that children with autism spectrum disorder (ASD) have age-related differences from controls in cortical volume (CV). It is less clear, however, if these persist in adulthood and whether these reflect alterations in cortical thickness (CT) or cortical surface area (SA). Hence, we used magnetic resonance imaging to investigate the relationship between age and CV, CT, and SA in 127 males aged 10 through 60 years (76 with ASD and 51 healthy controls). "Regional" analyses (using cortical parcellation) identified significant age-by-group interactions in both CV and CT (but not SA) in the temporal lobes and within these the fusiform and middle temporal gyri. Spatially nonbiased "vertex-based" analysis replicated these results and identified additional "age-by-group" interactions for CT within superior temporal, inferior and medial frontal, and inferior parietal cortices. Here, CV and CT were 1) significantly negatively correlated with age in controls, but not in ASD, and 2) smaller in ASD than controls in childhood but vice versa in adulthood. Our findings suggest that CV dysmaturation in ASD extends beyond childhood, affects brain regions crucial to social cognition and language, and is driven by CT dysmaturation. This may reflect primary abnormalities in cortical plasticity and/or be secondary to disturbed interactions between individuals with ASD and their environment.
C1 [Raznahan, Armin] Kings Coll London, Inst Psychiat, Dept Child & Adolescent Psychiat, London SE5 8AF, England.
[Toro, Roberto; Paus, Tomas] Univ Nottingham, Brain & Body Ctr, Nottingham NG7 2RD, England.
[Daly, Eileen; Robertson, Dene; Murphy, Clodagh; Deeley, Quinton; Murphy, Declan G. M.] Kings Coll London, Inst Psychiat, Sect Brain Maturat, Dept Psychol Med, London SE5 8AF, England.
[Bolton, Patrick F.] Kings Coll London, Inst Psychiat, MRC Ctr Social Genet & Dev Psychiat, London SE5 8AF, England.
[Paus, Tomas] McGill Univ, Montreal Neurol Inst, Montreal, PQ H3A 2B4, Canada.
RP Raznahan, A (reprint author), Kings Coll London, Inst Psychiat, Dept Child & Adolescent Psychiat, London SE5 8AF, England.
EM armin.raznahan@iop.kcl.ac.uk
RI daly, eileen/B-6716-2011; Raznahan, Armin/F-4534-2012; Bolton,
Patrick/E-8501-2010
OI Bolton, Patrick/0000-0002-5270-6262
FU UK Medical Research Council [G0701370]
FX UK Medical Research Council Clinical Research Training Fellowship (A. R.
to G0701370).
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NR 57
TC 61
Z9 64
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 1047-3211
J9 CEREB CORTEX
JI Cereb. Cortex
PD JUN
PY 2010
VL 20
IS 6
BP 1332
EP 1340
DI 10.1093/cercor/bhp198
PG 9
WC Neurosciences
SC Neurosciences & Neurology
GA 600KW
UT WOS:000277985800008
PM 19819933
ER
PT J
AU Virues-Ortega, J
AF Virues-Ortega, Javier
TI Applied behavior analytic intervention for autism in early childhood:
Meta-analysis, meta-regression and dose-response meta-analysis of
multiple outcomes
SO CLINICAL PSYCHOLOGY REVIEW
LA English
DT Review
DE Autism spectrum disorders; Applied behavior analysis; Language;
Meta-analysis
ID PERVASIVE DEVELOPMENTAL DISORDER; YOUNG-CHILDREN; SPECTRUM DISORDERS;
MENTAL-RETARDATION; FOLLOW-UP; HETEROGENEITY; PRESCHOOLERS; FEASIBILITY;
INDIVIDUALS; PREDICTORS
AB A number of clinical trials and single-subject studies have been published measuring the effectiveness of long-term, comprehensive applied behavior analytic (ABA) intervention for young children with autism. However, the overall appreciation of this literature through standardized measures has been hampered by the varying methods, designs, treatment features and quality standards of published studies. In an attempt to fill this gap in the literature, state-of-the-art meta-analytical methods were implemented, including quality assessment, sensitivity analysis, meta-regression, dose-response meta-analysis and meta-analysis of studies of different metrics. Results suggested that long-term, comprehensive ABA intervention leads to (positive) medium to large effects in terms of intellectual functioning, language development, acquisition of daily living skills and social functioning in children with autism. Although favorable effects were apparent across all outcomes, language-related outcomes (IQ receptive and expressive language, communication) were superior to non-verbal IQ social functioning and daily living skills, with effect sizes approaching 1.5 for receptive and expressive language and communication skills. Dose-dependant effect sizes were apparent by levels of total treatment hours for language and adaptation composite scores. Methodological issues relating ABA clinical trials for autism are discussed. (c) 2010 Elsevier Ltd. All rights reserved.
C1 [Virues-Ortega, Javier] Inst Salud Carlos III, Ctr Nacl Epidemiol, CIBERNED, Madrid 28029, Spain.
[Virues-Ortega, Javier] ABA Espana, Madrid, Spain.
RP Virues-Ortega, J (reprint author), Inst Salud Carlos III, Ctr Nacl Epidemiol, CIBERNED, Sinesio Delgado 6, Madrid 28029, Spain.
EM jvortega@cienciaconducta.com
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NR 67
TC 65
Z9 66
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0272-7358
J9 CLIN PSYCHOL REV
JI Clin. Psychol. Rev.
PD JUN
PY 2010
VL 30
IS 4
BP 387
EP 399
DI 10.1016/j.cpr.2010.01.008
PG 13
WC Psychology, Clinical
SC Psychology
GA 592ZU
UT WOS:000277421600002
PM 20223569
ER
PT J
AU Silverman, LB
Bennetto, L
Campana, E
Tanenhaus, MK
AF Silverman, Laura B.
Bennetto, Loisa
Campana, Ellen
Tanenhaus, Michael K.
TI Speech-and-gesture integration in high functioning autism
SO COGNITION
LA English
DT Article
DE Autism; Cross-modal integration; Eye movements; Gesture; Semantic
processing
ID SPOKEN LANGUAGE COMPREHENSION; CONVERSATIONAL HAND GESTURES;
VISUAL-SEARCH; SEMANTIC INFORMATION; SPECTRUM DISORDER; TALKING
TODDLERS; ICONIC GESTURES; NORMAL INFANTS; EYE-MOVEMENTS; CHILDREN
AB This study examined iconic gesture comprehension in autism, with the goal of assessing whether cross-modal processing difficulties impede speech-and-gesture integration. Participants were 19 adolescents with high functioning autism (HFA) and 20 typical controls matched on age, gender, verbal IQ and socio-economic status (SES). Gesture comprehension was assessed via quantitative analyses of visual fixations during a video-based task, using the visual world paradigm. Participants' eye movements were recorded while they watched videos of a person describing one of four shapes shown on a computer screen, using speech-and-gesture or speech-only descriptions. Participants clicked on the shape that the speaker described. Since gesture naturally precedes speech, earlier visual fixations to the target shape during speech-and-gesture compared to speech-only trials, would suggest immediate integration of auditory and visual information. Analyses of eye movements supported this pattern in control participants but not in individuals with autism: iconic gestures facilitated comprehension in typical individuals, while it hindered comprehension in those with autism. Cross-modal processing difficulties in autism were not accounted for by impaired unimodal speech or gesture processing. The results have important implications for the treatment of children and adults with this disorder. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Silverman, Laura B.] Univ Rochester, Sch Med & Dent, Div Neurodev & Behav Pediat, Rochester, NY 14642 USA.
[Silverman, Laura B.; Bennetto, Loisa] Univ Rochester, Dept Clin & Social Sci Psychol, Rochester, NY 14627 USA.
[Campana, Ellen] Arizona State Univ, Dept Psychol, Tempe, AZ 85287 USA.
[Tanenhaus, Michael K.] Univ Rochester, Dept Brain & Cognit Sci, Rochester, NY 14627 USA.
RP Silverman, LB (reprint author), Univ Rochester, Sch Med & Dent, Div Neurodev & Behav Pediat, Rochester, NY 14642 USA.
EM laura_silverman@urmc.rochester.edu
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NR 89
TC 10
Z9 11
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0010-0277
J9 COGNITION
JI Cognition
PD JUN
PY 2010
VL 115
IS 3
BP 380
EP 393
DI 10.1016/j.cognition.2010.01.002
PG 14
WC Psychology, Experimental
SC Psychology
GA 632OH
UT WOS:000280433500002
PM 20356575
ER
PT J
AU Cohen, AS
German, TC
AF Cohen, Adam S.
German, Tamsin C.
TI A reaction time advantage for calculating beliefs over public
representations signals domain specificity for 'theory of mind'
SO COGNITION
LA English
DT Article
DE Theory of mind; Domain specificity
ID TEMPORO-PARIETAL JUNCTION; THEORY-OF-MIND; FALSE-BELIEF;
NEUROPSYCHOLOGICAL EVIDENCE; INTENTIONAL STANCE; LOBE CONTRIBUTIONS;
AUTISM; BRAIN; PERFORMANCE; PRESCHOOLERS
AB In a task where participants' overt task was to track the location of an object across a sequence of events, reaction times to unpredictable probes requiring an inference about a social agent's beliefs about the location of that object were obtained. Reaction times to false belief situations were faster than responses about the (false) contents of a map showing the location of the object (Experiment 1) and about the (false) direction of an arrow signaling the location of the object (Experiment 2). These results are consistent with developmental, neuro-imaging and neuropsychological evidence that there exist domain specific mechanisms within human cognition for encoding and reasoning about mental states. Specialization of these mechanisms may arise from either core cognitive architecture or via the accumulation of expertise in the social domain. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Cohen, Adam S.; German, Tamsin C.] Univ Calif Santa Barbara, Dept Psychol, Santa Barbara, CA 93106 USA.
RP German, TC (reprint author), Univ Calif Santa Barbara, Dept Psychol, Santa Barbara, CA 93106 USA.
EM german@psych.ucsb.edu
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NR 54
TC 14
Z9 14
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0010-0277
J9 COGNITION
JI Cognition
PD JUN
PY 2010
VL 115
IS 3
BP 417
EP 425
DI 10.1016/j.cognition.2010.03.001
PG 9
WC Psychology, Experimental
SC Psychology
GA 632OH
UT WOS:000280433500005
PM 20350721
ER
PT J
AU Shamay-Tsoory, SG
Aharon-Peretz, J
Adler, N
AF Shamay-Tsoory, Simone G.
Aharon-Peretz, Judith
Adler, Noga
TI Brain Asymmetry in Emotional Processing in Asperger Syndrome
SO COGNITIVE AND BEHAVIORAL NEUROLOGY
LA English
DT Article
DE brain asymmetry; Asperger syndrome; emotional processing
ID AUTISM SPECTRUM DISORDERS; HIGH-FUNCTIONING AUTISM; RIGHT-HEMISPHERE;
IMPAIRED RECOGNITION; FACIAL EXPRESSIONS; INFANTILE-AUTISM; COMPLEX
EMOTIONS; AMYGDALA DAMAGE; SOCIAL EMOTIONS; NORMAL ADULTS
AB The role of brain asymmetry in emotional processing in Asperger syndrome (AS) is still largely unknown. Although the valence hypothesis predicts that positive emotions are processed preferentially by the left hemisphere and negative emotions by the right hemisphere, reports concerning laterality of emotion point to a left hemisphere advantage for complex emotion versus a right hemisphere advantage for basic emotions (the "type hypothesis''). In this study, we investigated the lateralization of basic versus complex (negative and positive) eye expressions in adults with AS in 2 consecutive experiments: in the first experiment, the performance of AS and healthy controls were compared in a divided visual field task. In the second experiment, the ability of participants with AS to identify eye expressions varying in valence and type was compared with that of patients with localized lesions in either the right or the left hemispheres. Controls were better in recognizing negative emotions presented to the left visual field and positive emotions presented to the right visual field, whereas individuals with AS failed to show this interaction effect. Lateralization of basic versus complex emotions was less evident although indeed controls identified better basic emotions presented to the right visual field. Furthermore, participants with AS exhibited a similar pattern of recognition of negative versus positive emotions to that of patients with left hemisphere damage. It is suggested that the pattern of performance of individuals with AS resembles that of patients with left hemisphere dysfunction.
C1 [Shamay-Tsoory, Simone G.; Aharon-Peretz, Judith; Adler, Noga] Univ Haifa, Dept Psychol, IL-31905 Haifa, Israel.
RP Shamay-Tsoory, SG (reprint author), Univ Haifa, Dept Psychol, IL-31905 Haifa, Israel.
EM sshamay@psy.haifa.ac.il
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NR 77
TC 4
Z9 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1543-3633
J9 COGN BEHAV NEUROL
JI Cogn. Behav. Neurol.
PD JUN
PY 2010
VL 23
IS 2
BP 74
EP 84
DI 10.1097/WNN.0b013e3181d748ec
PG 11
WC Behavioral Sciences; Clinical Neurology
SC Behavioral Sciences; Neurosciences & Neurology
GA 608GD
UT WOS:000278570500002
PM 20535055
ER
PT J
AU Kalbe, E
Schlegel, M
Sack, AT
Nowak, DA
Dafotakis, M
Bangard, C
Brand, M
Shamay-Tsoory, S
Onur, OA
Kessler, J
AF Kalbe, Elke
Schlegel, Marius
Sack, Alexander T.
Nowak, Dennis A.
Dafotakis, Manuel
Bangard, Christopher
Brand, Matthias
Shamay-Tsoory, Simone
Onur, Oezguer A.
Kessler, Josef
TI Dissociating cognitive from affective theory of mind: A TMS study
SO CORTEX
LA English
DT Article
DE Theory of Mind; Transcranial magnetic stimulation; Dorsolateral
prefrontal cortex; 5 cm rule
ID TRANSCRANIAL MAGNETIC STIMULATION; DORSOLATERAL PREFRONTAL CORTEX;
HIGH-FUNCTIONING AUTISM; SPATIAL WORKING-MEMORY; SOCIAL COGNITION;
FRONTOTEMPORAL DEMENTIA; ASPERGER-SYNDROME; FRONTAL-LOBE; STORY
COMPREHENSION; EXECUTIVE FUNCTION
AB Introduction: "Theory of Mind" (TOM), i.e., the ability to infer other persons' mental states, is a key function of social cognition. It is increasingly recognized to form a multidimensional construct. One differentiation that has been proposed is that between cognitive and affective ToM, whose neural correlates remain to be identified. We aimed to ascertain the possible role of the right dorsolateral prefrontal cortex (DLPFC) for cognitive ToM as opposed to affective ToM processes.
Methods: 1 Hz repetitive transcranial magnetic stimulation (rTMS) was used to interfere offline with cortical function of the right DLPFC in healthy male subjects who subsequently had to perform a computerized task assessing cognitive and affective ToM.
Results: RTMS over the right DLPFC induced a selective effect on cognitive but not affective ToM. More specifically, a significant acceleration of reaction times in cognitive ToM compared to affective ToM and control items was observed in the experimental (right DLPFC) compared to the control (vertex) rTMS stimulation condition.
Conclusions: Our findings provide evidence for the functional independence of cognitive from affective ToM. Furthermore, they point to an important role of the right DLPFC within neural networks mediating cognitive ToM. Possible underlying mechanisms of the acceleration of cognitive ToM processing under rTMS are discussed. (C) 2009 Elsevier Srl. All rights reserved.
C1 [Kalbe, Elke; Nowak, Dennis A.; Dafotakis, Manuel; Onur, Oezguer A.] Res Ctr Julich, Inst Neurosci & Med INM 3, Cognit Neurol Sect, D-52425 Julich, Germany.
[Schlegel, Marius; Dafotakis, Manuel; Onur, Oezguer A.; Kessler, Josef] Univ Hosp Cologne, Dept Neurol, Cologne, Germany.
[Sack, Alexander T.] Maastricht Univ, Fac Psychol, Dept Cognit Neurosci, Maastricht, Netherlands.
[Bangard, Christopher] Univ Hosp Cologne, Dept Radiol, Cologne, Germany.
[Brand, Matthias] Univ Duisburg Essen, Dept Gen Psychol, Essen, Germany.
[Brand, Matthias] Erwin L Hahn Inst Magnet Resonance Imaging, Essen, Germany.
[Shamay-Tsoory, Simone] Univ Haifa, Dept Psychol, IL-31999 Haifa, Israel.
[Shamay-Tsoory, Simone] Univ Haifa, Brain & Behav Ctr, IL-31999 Haifa, Israel.
RP Kalbe, E (reprint author), Res Ctr Julich, Inst Neurosci & Med INM 3, Cognit Neurol Sect, Leo Brandt Str 5, D-52425 Julich, Germany.
EM e.kalbe@fz-juelich.de
FU Faculty of Psychology, Maastricht University; EC-FP6-project DiMI
[LSHBCT-2005-512146]
FX We thank Michelle Moerel, Faculty of Psychology, Maastricht University,
for support in graphical image processing, and Ingo Meister and Mitra
Ameli, Department of Neurology, University of Cologne, for assistance in
MRI and rTMS. Furthermore, the work of the first author was funded in
part by the EC-FP6-project DiMI, LSHBCT-2005-512146.
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NR 118
TC 56
Z9 60
PU ELSEVIER MASSON
PI MILANO
PA VIA PALEOCAPA 7, 20121 MILANO, ITALY
SN 0010-9452
J9 CORTEX
JI Cortex
PD JUN
PY 2010
VL 46
IS 6
BP 769
EP 780
DI 10.1016/j.cortex.2009.07.010
PG 12
WC Behavioral Sciences; Neurosciences
SC Behavioral Sciences; Neurosciences & Neurology
GA 597RZ
UT WOS:000277780100007
PM 19709653
ER
PT J
AU Stein, DJ
Grant, JE
Franklin, ME
Keuthen, N
Lochner, C
Singer, HS
Woods, DW
AF Stein, Dan J.
Grant, Jon E.
Franklin, Martin E.
Keuthen, Nancy
Lochner, Christine
Singer, Harvey S.
Woods, Douglas W.
TI TRICHOTILLOMANIA (HAIR PULLING DISORDER), SKIN PICKING DISORDER, AND
STEREOTYPIC MOVEMENT DISORDER: TOWARD DSM-V
SO DEPRESSION AND ANXIETY
LA English
DT Review
DE trichotillontania; hair pulling; skin picking; stereotypic movement
disorder; stereotypy
ID OBSESSIVE-COMPULSIVE DISORDER; SELF-INJURIOUS-BEHAVIOR; PERVASIVE
DEVELOPMENTAL DISORDERS; AUTISM SPECTRUM DISORDERS; IMPULSE-CONTROL
DISORDERS; BODY DYSMORPHIC DISORDER; HIGH-FUNCTIONING AUTISM;
LONGITUDINAL FOLLOW-UP; REPETITIVE BEHAVIOR; CLINICAL CHARACTERISTICS
AB In DSM-IV-TR, trichotillomania (TTM) is classified as an impulse control disorder (not classified elsewhere), skin picking lacks its own diagnostic category (but might be diagnosed as an impulse control disorder not otherwise specified), and stereotypic movement disorder is classified as a disorder usually first diagnosed in infancy, childhood, or adolescence. ICD-10 classifies TTM as a habit and impulse disorder; and includes stereotyped movement disorders in a section on other behavioral and emotional disorders with onset usually occurring in childhood and adolescence. This article provides a focused review of nosological issues relevant to DSM-V; given recent empirical findings. This review presents a number of options and preliminary recommendations to be considered for DSM-V (1) Although TTM fits optimally into a category of body-focused repetitive behavioral disorders, in a nosology comprised of relatively few major categories it fits best within a category of motoric obsessive-compulsive spectrum disorders, (2) available evidence does not support continuing to include (current) diagnostic criteria B and C for TTM in DSM-V (3) the text for TTM should be updated to describe subtypes and forms of hair pulling, (4) there are persuasive reasons for referring to rim as "hair pulling disorder (trichotillomania)," (5) diagnostic criteria for skin picking disorder should be included in DSM-V or in DSM-Vs Appendix of Criteria Sets Provided for Further Study, and (6) the diagnostic criteria for stereotypic movement disorder should be clarified and simplified, bringing them in line with those for hair pulling and skin picking disorder. Depression and Anxiety 27:611-626, 2010. (C) 2010 Wiley-Liss, Inc.
C1 [Stein, Dan J.] Univ Cape Town, Dept Psychiat, ZA-7925 Cape Town, South Africa.
[Grant, Jon E.] Univ Minnesota, Dept Psychiat, Minneapolis, MN 55455 USA.
[Franklin, Martin E.] Univ Penn, Dept Psychiat, Philadelphia, PA 19104 USA.
[Keuthen, Nancy] Harvard Univ, Sch Med, Dept Psychiat, Boston, MA 02115 USA.
[Lochner, Christine] Univ Stellenbosch, Dept Psychiat, Matieland, South Africa.
[Singer, Harvey S.] Johns Hopkins Univ, Dept Neurol, Baltimore, MD 21218 USA.
[Woods, Douglas W.] Univ Wisconsin, Dept Psychiat, Milwaukee, WI 53201 USA.
RP Stein, DJ (reprint author), Groote Schuur Hosp, Dept Psychiat, J2 Anzio Rd, ZA-7925 Cape Town, South Africa.
EM dan.stein@uct.ac.za
RI Citations, TLC SAB/C-4006-2011; Stein, Dan/A-1752-2008
OI Stein, Dan/0000-0001-7218-7810
FU Astrozeneca; Eli-Lilly; GlaxoSmithKline; Jazz Pharmaceuticals; Johnson
Johnson; Lundbeck; Orion; Pfizer; Pharmacia; Roche; Servier; Solvay;
Sumitomo; Takeda; Tikvah; Wyeth
FX Dr. Stein has received research grants and/or consultancy honoraria from
Astrozeneca, Eli-Lilly, GlaxoSmithKline, Jazz Pharmaceuticals, Johnson &
Johnson, Lundbeck, Orion, Pfizer, Pharmacia, Roche, Servier, Solvay,
Sumitomo, Takeda, Tikvah, and Wyeth.
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NR 142
TC 62
Z9 62
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1091-4269
EI 1520-6394
J9 DEPRESS ANXIETY
JI Depress. Anxiety
PD JUN
PY 2010
VL 27
IS 6
BP 611
EP 626
DI 10.1002/da.20700
PG 16
WC Psychology, Clinical; Psychiatry; Psychology
SC Psychology; Psychiatry
GA 608GY
UT WOS:000278572700008
PM 20533371
ER
PT J
AU Roehl, HH
Pacifici, M
AF Roehl, Henry H.
Pacifici, Maurizio
TI Shop Talk: Sugars, Bones, and a Disease Called Multiple Hereditary
Exostoses
SO DEVELOPMENTAL DYNAMICS
LA English
DT Editorial Material
DE cartilage; bone; tumor; exostoses; osteochondroma; heparan sulfate
ID HEPARAN-SULFATE; GROWTH-PLATE; GENE; OSTEOCHONDROMAS; CLONING; AUTISM;
EXT1
AB October 29, 2009, researchers and physicians gathered at the Sheraton Four Points Hotel in Boston for 4 days to discuss a disease called multiple hereditary exostoses (MHE). MHE is an autosomal dominant disease that is associated with mutations in two enzymes that are required for heparan sulfate (HS) synthesis. Children with the disease form numerous benign bone tumors (osteochondromas) and have >2% chance of developing chondrosarcoma. The aim of the meeting was to generate new ideas for the diagnoses, treatment, and cure of this disease. Discussions ranged from orthopedic surgical treatment and patients' personal experiences to fundamental questions in skeletal biology and the precise molecular role that HS plays in developmental signaling pathways. Developmental Dynamics 239:1901 1904, 2010. (C) 2010 Wiley-Liss, Inc.
C1 [Roehl, Henry H.] Univ Sheffield, MRC Ctr Dev & Biomed Genet, Sheffield S10 2TN, S Yorkshire, England.
[Pacifici, Maurizio] Thomas Jefferson Univ, Sch Med, Dept Orthopaed Surg, Philadelphia, PA 19107 USA.
RP Roehl, HH (reprint author), Univ Sheffield, MRC Ctr Dev & Biomed Genet, Firth Court,Western Bank, Sheffield S10 2TN, S Yorkshire, England.
EM h.roehl@sheffield.ac.uk
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NR 23
TC 3
Z9 3
PU WILEY-LISS
PI HOBOKEN
PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 1058-8388
J9 DEV DYNAM
JI Dev. Dyn.
PD JUN
PY 2010
VL 239
IS 6
BP 1901
EP 1904
DI 10.1002/dvdy.22290
PG 4
WC Anatomy & Morphology; Developmental Biology
SC Anatomy & Morphology; Developmental Biology
GA 610UB
UT WOS:000278761700031
PM 20503385
ER
PT J
AU Patel, DR
Greydanus, DE
Calles, JL
Pratt, HD
AF Patel, Dilip R.
Greydanus, Donald E.
Calles, Joseph L., Jr.
Pratt, Helen D.
TI Developmental Disabilities Across the Lifespan
SO DM DISEASE-A-MONTH
LA English
DT Article
ID AUTISM SPECTRUM DISORDERS; SELF-INJURIOUS-BEHAVIOR; DEFICIT
HYPERACTIVITY DISORDER; HEALTH-CARE NEEDS;
QUALITY-STANDARDS-SUBCOMMITTEE; RECEPTIVE LANGUAGE DISORDER;
CHILD-NEUROLOGY-SOCIETY; ACADEMY-OF-NEUROLOGY; EARLY ADULT LIFE;
CEREBRAL-PALSY
C1 [Patel, Dilip R.] Michigan State Univ, Coll Human Med, Dept Pediat & Human Dev, E Lansing, MI 48824 USA.
[Patel, Dilip R.] Western Michigan Univ, Dept Speech Pathol & Audiol, Kalamazoo Ctr Med Studies, Div Neurodev Disabil,Pediat Residency Program, Kalamazoo, MI 49008 USA.
[Greydanus, Donald E.] Michigan State Univ, Coll Human Med, Dept Pediat & Human Dev, Pediat Residency Program,Kalamazoo Ctr Med Studie, Kalamazoo, MI USA.
[Calles, Joseph L., Jr.] Michigan State Univ, Coll Human Med Child & Adolescent Psychiat, Dept Psychiat, Kalamazoo Ctr Med Studies, Kalamazoo, MI USA.
[Pratt, Helen D.] Michigan State Univ, Coll Human Med, Kalamazoo Ctr Med Studies, Dept Pediat & Human Dev,Div Dev Behav Pediat, Kalamazoo, MI USA.
RP Patel, DR (reprint author), Michigan State Univ, Coll Human Med, Dept Pediat & Human Dev, E Lansing, MI 48824 USA.
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NR 348
TC 1
Z9 1
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0011-5029
J9 DM-DIS MON
JI DM-Dis.-a-Mon.
PD JUN
PY 2010
VL 56
IS 6
BP 305
EP 397
DI 10.1016/j.disamonth.2010.02.001
PG 93
WC Medicine, General & Internal
SC General & Internal Medicine
GA 609VX
UT WOS:000278687200002
ER
PT J
AU Skoe, E
Kraus, N
AF Skoe, Erika
Kraus, Nina
TI Auditory Brain Stem Response to Complex Sounds: A Tutorial
SO EAR AND HEARING
LA English
DT Review
ID FREQUENCY-FOLLOWING RESPONSES; MISSING FUNDAMENTAL STIMULI;
LANGUAGE-IMPAIRED CHILDREN; AUTISM SPECTRUM DISORDERS; NORMAL-HEARING
ADULTS; SPEECH-IN-NOISE; LEARNING-PROBLEMS; SELECTIVE ATTENTION;
EVOKED-POTENTIALS; MUSICAL EXPERIENCE
AB This tutorial provides a comprehensive overview of the methodological approach to collecting and analyzing auditory brain stem responses to complex sounds (cABRs). cABRs provide a window into how behaviorally relevant sounds such as speech and music are processed in the brain. Because temporal and spectral characteristics of sounds are preserved in this subcortical response, cABRs can be used to assess specific impairments and enhancements in auditory processing. Notably, subcortical auditory function is neither passive nor hardwired but dynamically interacts with higher-level cognitive processes to refine how sounds are transcribed into neural code. This experience-dependent plasticity, which can occur on a number of time scales (e.g., life-long experience with speech or music, short-term auditory training, on-line auditory processing), helps shape sensory perception. Thus, by being an objective and noninvasive means for examining cognitive function and experience-dependent processes in sensory activity, cABRs have considerable utility in the study of populations where auditory function is of interest (e.g., auditory experts such as musicians, and persons with hearing loss, auditory processing, and language disorders). This tutorial is intended for clinicians and researchers seeking to integrate cABRs into their clinical or research programs.
C1 [Skoe, Erika; Kraus, Nina] Northwestern Univ, Dept Commun Sci, Evanston, IL 60208 USA.
[Kraus, Nina] Northwestern Univ, Dept Neurobiol & Physiol, Evanston, IL 60208 USA.
RP Skoe, E (reprint author), Northwestern Univ, Dept Commun Sci, 2240 Campus Dr, Evanston, IL 60208 USA.
EM eeskoe@northwestern.edu
FU NSF [0842376]; NIH [R01 DC01510, F32 DC008052]
FX This work was supported by NSF 0842376 and NIH R01 DC01510, F32
DC008052.
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NR 140
TC 127
Z9 134
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0196-0202
J9 EAR HEARING
JI Ear Hear.
PD JUN
PY 2010
VL 31
IS 3
BP 302
EP 324
DI 10.1097/AUD.0b013e3181cdb272
PG 23
WC Audiology & Speech-Language Pathology; Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Otorhinolaryngology
GA 618QL
UT WOS:000279370700002
PM 20084007
ER
PT J
AU Machalicek, W
O'Reilly, MF
Rispoli, M
Davis, T
Lang, R
Franco, JH
Chan, JM
AF Machalicek, Wendy
O'Reilly, Mark F.
Rispoli, Mandy
Davis, Tonya
Lang, Russell
Franco, Jessica Hetlinger
Chan, Jeffrey M.
TI Training Teachers to Assess the Challenging Behaviors of Students with
Autism Using Video Tele-Conferencing
SO EDUCATION AND TRAINING IN AUTISM AND DEVELOPMENTAL DISABILITIES
LA English
DT Article
ID FUNCTIONAL-ANALYSIS METHODOLOGY; DEVELOPMENTAL-DISABILITIES;
INTERVENTION; SETTINGS; MODEL; IMPLEMENTATION; ACQUISITION
AB We examined the effects of performance feedback provided via video tele-conferencing (VTC) on the acquisition of functional analyst's procedures by six teachers. A university supervisor used VTC equipment (i.e., computers equipped with web cameras and Internet) to provide feedback to teachers learning to implement functional analysis conditions (i.e., escape, attention, and play) with students with autism. Multiple baseline designs across teacher-student dyads with embedded multi-element designs were used to evaluate the effects of performance feedback delivered via VTC on the percentage of functional analysis procedures implemented correctly. Results indicated that teachers learned to implement functional analysis conditions following training (M duration of training = 75 minutes; range = 60-95 minutes). Rice tilts were maintained fir a number of weeks following the termination of performance feedback (M = 5 weeks; range = 4-9 weeks), but leacher performance declined thereafter. Video conferencing technology may provide supervisors an efficacious way to deliver performance feedback to teachers learning research-based strategies.
C1 [Machalicek, Wendy] Univ Wisconsin, Dept Rehabil Psychol & Special Educ, Madison, WI 53706 USA.
[O'Reilly, Mark F.] Univ Texas Austin, Austin, TX 78712 USA.
[Rispoli, Mandy] Texas A&M, College Stn, TX USA.
[Davis, Tonya] Baylor Univ, Waco, TX 76798 USA.
[Lang, Russell] Texas State Univ San Marcos, San Marcos, TX USA.
[Franco, Jessica Hetlinger] Autism Community Network, San Antonio, TX USA.
[Chan, Jeffrey M.] No Illinois Univ, De Kalb, IL 60115 USA.
RP Machalicek, W (reprint author), Univ Wisconsin, Dept Rehabil Psychol & Special Educ, 432 E Campus Mall,Rm 310, Madison, WI 53706 USA.
EM machalicek@wisc.edu
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NR 23
TC 9
Z9 9
PU COUNCIL EXCEPTIONAL CHILDREN
PI ARLINGTON
PA 1110 N GLEBE RD, ARLINGTON, VA 22201-5704 USA
SN 2154-1647
J9 EDUC TRAIN AUTISM DE
JI Educ. Train. Autism Dev. Disabil.
PD JUN
PY 2010
VL 45
IS 2
BP 203
EP 215
PG 13
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA 596LU
UT WOS:000277687300004
ER
PT J
AU Dogoe, MS
Banda, DR
Lock, RH
AF Dogoe, Maud S.
Banda, Devender R.
Lock, Robin H.
TI Acquisition and Generalization of the Picture Exchange Communication
System Behaviors across Settings, Persons, and Stimulus Classes with
Three Students with Autism
SO EDUCATION AND TRAINING IN AUTISM AND DEVELOPMENTAL DISABILITIES
LA English
DT Article
ID ALTERNATIVE COMMUNICATION; FUNCTIONAL COMMUNICATION; SPEECH DEVELOPMENT;
CHILDREN; PECS; INTERVENTION; DISABILITIES; ADULTS; SKILLS; HOME
AB This study examined the acquisition and generalization of requesting behaviors learned through PEGS with three children with autism. A single-subject multiple baseline across participants design was used to determine the effects of PECS. Results indicated that all three participants acquired PEGS skills for requesting and generalized the skills across settings and persons. However, only two of the three participants met criterion on the generalization across stimulus class probes. Implications and suggestions for future research are discussed. This study provides preliminary data on generalization of PEG S across stimulus classes by persons with autism.
C1 [Banda, Devender R.] Texas Tech Univ, Coll Educ, Dept Educ Psychol & Leadership, Lubbock, TX 79409 USA.
[Dogoe, Maud S.] Cent Michigan Univ, Mt Pleasant, MI 48859 USA.
RP Banda, DR (reprint author), Texas Tech Univ, Coll Educ, Dept Educ Psychol & Leadership, POB 41071, Lubbock, TX 79409 USA.
EM devender.banda@ttu.edu
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NR 45
TC 0
Z9 0
PU COUNCIL EXCEPTIONAL CHILDREN
PI ARLINGTON
PA 1110 N GLEBE RD, ARLINGTON, VA 22201-5704 USA
SN 2154-1647
J9 EDUC TRAIN AUTISM DE
JI Educ. Train. Autism Dev. Disabil.
PD JUN
PY 2010
VL 45
IS 2
BP 216
EP 229
PG 14
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA 596LU
UT WOS:000277687300005
ER
PT J
AU Lang, R
O'Reilly, MF
Sigafoos, J
Machalicek, W
Rispoli, M
Shogren, K
Chan, JM
Davis, T
Lancioni, G
Hopkins, S
AF Lang, Russell
O'Reilly, Mark F.
Sigafoos, Jeff
Machalicek, Wendy
Rispoli, Mandy
Shogren, Karrie
Chan, Jeffrey M.
Davis, Tonya
Lancioni, Giulio
Hopkins, Shannon
TI Review of Teacher Involvement in the Applied Intervention Research for
Children with Autism Spectrum Disorders
SO EDUCATION AND TRAINING IN AUTISM AND DEVELOPMENTAL DISABILITIES
LA English
DT Review
ID SOCIAL STORIES; DEVELOPMENTAL-DISABILITIES; SPECIAL-EDUCATION;
FUNCTIONAL COMMUNICATION; CHALLENGING BEHAVIORS; ACTIVITY SCHEDULES;
GENERAL-EDUCATION; VOCAL STEREOTYPY; SELF-MANAGEMENT; YOUNG-CHILDREN
AB This review examined the involvement of teachers in the intervention research for children with autism spectrum disorders (ASD) from 1996 through February 2008. Forty-nine studies involving teachers of children with ASD were coded for different types of involvement. Findings are discussed in regards to three issues: (a) the manner in which teachers have been involved in autism research, (b) how teachers were trained to implement research based practices, and (c) teachers' perceptions of interventions (i.e. social validity). Results showed that teachers have been included in a variety of meaningful ways in recent research. However, our review also highlights the need for additional research. regarding teachers' perceptions and training teachers to effectively implement research-based interventions.
C1 [Lang, Russell] Texas State Univ San Marcos, San Marcos, TX 78666 USA.
[O'Reilly, Mark F.] Univ Texas Austin, Austin, TX 78712 USA.
[Sigafoos, Jeff] Victoria Univ, Wellington, New Zealand.
[Machalicek, Wendy] Univ Wisconsin, Madison, WI 53706 USA.
[Rispoli, Mandy] Texas A&M, College Stn, TX USA.
[Shogren, Karrie] Univ Illinois Urban Champaign, Urbana, IL USA.
[Chan, Jeffrey M.] No Illinois Univ, De Kalb, IL 60115 USA.
[Davis, Tonya] Baylor Univ, Waco, TX 76798 USA.
[Lancioni, Giulio] Univ Bari, I-70121 Bari, Italy.
[Hopkins, Shannon] Autism Treatment Ctr, Dallas, TX USA.
RP Lang, R (reprint author), Texas State Univ San Marcos, 601 Univ Dr, San Marcos, TX 78666 USA.
EM russlang@education.ucsb.edu
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NR 104
TC 13
Z9 13
PU COUNCIL EXCEPTIONAL CHILDREN
PI ARLINGTON
PA 1110 N GLEBE RD, ARLINGTON, VA 22201-5704 USA
SN 2154-1647
J9 EDUC TRAIN AUTISM DE
JI Educ. Train. Autism Dev. Disabil.
PD JUN
PY 2010
VL 45
IS 2
BP 268
EP 283
PG 16
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA 596LU
UT WOS:000277687300008
ER
PT J
AU Travers, J
Tincani, M
AF Travers, Jason
Tincani, Matt
TI Sexuality Education for Individuals with Autism Spectrum Disorders:
Critical Issues and Decision Making Guidelines
SO EDUCATION AND TRAINING IN AUTISM AND DEVELOPMENTAL DISABILITIES
LA English
DT Article
ID SEVERE INTELLECTUAL DISABILITIES; DEVELOPMENTAL-DISABILITIES; PARENTAL
PERSPECTIVE; ADOLESCENTS; PEOPLE; ADULTS; MANAGEMENT; BEHAVIORS;
KNOWLEDGE; ATTITUDES
AB Individuals with autism spectrum disorders (ASD) present unique needs regarding sexuality education. While the topic of sexuality has received increased attention in the fields of intellectual and developmental disabilities generally, less consideration has focused on the unique needs of individuals with ASD specifically. This paper presents one position in support of sexuality education for children and adolescents with ASD. The nature of human sexuality is discussed to provide a context for the rights of individuals with ASD to learn about their sexuality. Further justification far providing sexuality education in terms of the unique characteristics of this population is offered in conjunction with potential consequences of failing to provide sexuality education. Lastly, information regarding a decision-making process for sexuality education curriculum is presented, including the responsibilities of families and professionals providing sexuality education.
C1 [Tincani, Matt] Temple Univ, Philadelphia, PA 19122 USA.
[Travers, Jason] Univ Nevada, Las Vegas, NV 89154 USA.
RP Tincani, M (reprint author), Temple Univ, 1301 Cecil B Moore Ave,Ritter Hall 367, Philadelphia, PA 19122 USA.
EM tincani@temple.edu
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NR 36
TC 8
Z9 8
PU COUNCIL EXCEPTIONAL CHILDREN
PI ARLINGTON
PA 1110 N GLEBE RD, ARLINGTON, VA 22201-5704 USA
SN 2154-1647
J9 EDUC TRAIN AUTISM DE
JI Educ. Train. Autism Dev. Disabil.
PD JUN
PY 2010
VL 45
IS 2
BP 284
EP 293
PG 10
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA 596LU
UT WOS:000277687300009
ER
PT J
AU Sauvage, D
AF Sauvage, D.
TI Autism, information, deontology
SO ENCEPHALE-REVUE DE PSYCHIATRIE CLINIQUE BIOLOGIQUE ET THERAPEUTIQUE
LA French
DT Editorial Material
RP Sauvage, D (reprint author), 6 Rue Racine, F-37000 Tours, France.
EM domsauvage@wanadoo.fr
NR 0
TC 0
Z9 0
PU MASSON EDITEUR
PI MOULINEAUX CEDEX 9
PA 21 STREET CAMILLE DESMOULINS, ISSY, 92789 MOULINEAUX CEDEX 9, FRANCE
SN 0013-7006
J9 ENCEPHALE
JI Enceph.-Rev. Psychiatr. Clin. Biol. Ther.
PD JUN
PY 2010
VL 36
IS 3
BP 187
EP 188
DI 10.1016/j.encep.2009.10.002
PG 2
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA 629SX
UT WOS:000280221100001
PM 20620260
ER
PT J
AU [Anonymous]
AF [Anonymous]
TI Epigenetic contribution to autism spectrum disorders investigated
SO EPIGENOMICS
LA English
DT News Item
CR Nguyen A, 2010, FASEB J, V24, P3036, DOI [10.1096/fj.10-154484, 10.1096/fj.09-154484]
NR 1
TC 0
Z9 0
PU FUTURE MEDICINE LTD
PI LONDON
PA UNITEC HOUSE, 3RD FLOOR, 2 ALBERT PLACE, FINCHLEY CENTRAL, LONDON, N3
1QB, ENGLAND
SN 1750-1911
J9 EPIGENOMICS-UK
JI Epigenomics
PD JUN
PY 2010
VL 2
IS 3
BP 355
EP 355
PG 1
WC Genetics & Heredity
SC Genetics & Heredity
GA 607US
UT WOS:000278533000004
ER
PT J
AU Wynder, C
Stalker, L
Doughty, ML
AF Wynder, Christopher
Stalker, Leanne
Doughty, Martin L.
TI Role of H3K4 demethylases in complex neurodevelopmental diseases
SO EPIGENOMICS
LA English
DT Review
DE autism; brain development; gene regulation; histone demethylation
ID HISTONE LYSINE METHYLATION; EMBRYONIC STEM-CELLS; LINKED
MENTAL-RETARDATION; AUTISM-SPECTRUM-DISORDER; TRANSLATIONAL PROFILING
APPROACH; DOMAIN-CONTAINING PROTEINS; ESCAPES X-INACTIVATION;
RETT-SYNDROME; GENE-EXPRESSION; BREAST-CANCER
AB Significant neurological disorders can result from subtle perturbations of gene regulation that are often linked to epigenetic regulation. Proteins that regulate the methylation of lysine 4 of histone H3 (H3K4) and play a central role in epigenetic regulation, and mutations in genes encoding these enzymes have been identified in both autism and Rett syndrome. The H3K4 demethylases remove methyl groups from lysine 4 leading to loss of RNA polymerase binding and transcriptional repression. When these proteins are mutated, brain development is altered. Currently, little is known regarding how these gene regulators function at the genomic level. In this article, we will discuss findings that link H3K4 demethylases to neurodevelopment and neurological disease.
C1 [Wynder, Christopher; Stalker, Leanne] McMaster Univ, McMaster Stem Cell & Canc Inst, Hamilton, ON L8N 3Z5, Canada.
[Stalker, Leanne] McMaster Univ, Dept Biochem & Biomed Sci, Fac Hlth Sci, Hamilton, ON L8N 3Z5, Canada.
[Doughty, Martin L.] Uniformed Serv Univ Hlth Sci, Dept Anat Physiol & Genet, Bethesda, MD 20814 USA.
RP Wynder, C (reprint author), McMaster Univ, McMaster Stem Cell & Canc Inst, Hamilton, ON L8N 3Z5, Canada.
EM dr_cwynder@yahoo.com
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NR 110
TC 4
Z9 5
PU FUTURE MEDICINE LTD
PI LONDON
PA UNITEC HOUSE, 3RD FLOOR, 2 ALBERT PLACE, FINCHLEY CENTRAL, LONDON, N3
1QB, ENGLAND
SN 1750-1911
J9 EPIGENOMICS-UK
JI Epigenomics
PD JUN
PY 2010
VL 2
IS 3
BP 407
EP 418
DI 10.2217/EPI.10.12
PG 12
WC Genetics & Heredity
SC Genetics & Heredity
GA 607US
UT WOS:000278533000011
PM 22121901
ER
PT J
AU Cuccaro, M
Tuchman, R
Hamilton, K
Gilbert, JR
Wright, HH
Abramson, RK
Pericak-Vance, MA
AF Cuccaro, M.
Tuchman, R.
Hamilton, K.
Gilbert, J. R.
Wright, H. H.
Abramson, R. K.
Pericak-Vance, M. A.
TI DEFINING THE AUTISM-EPILEPSY PHENOTYPE
SO EPILEPSIA
LA English
DT Meeting Abstract
CT 9th European Congress on Epileptology
CY JUN 27-JUL 01, 2010
CL Rhodes, GREECE
C1 [Cuccaro, M.; Hamilton, K.; Gilbert, J. R.; Pericak-Vance, M. A.] Univ Miami, Sch Med, Miami, FL USA.
[Tuchman, R.] Miami Childrens Hosp, Weston, ACT, Australia.
[Wright, H. H.; Abramson, R. K.] Univ S Carolina, Sch Med, Columbia, SC USA.
NR 0
TC 0
Z9 0
PU WILEY-BLACKWELL PUBLISHING, INC
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0013-9580
J9 EPILEPSIA
JI Epilepsia
PD JUN
PY 2010
VL 51
SU 4
SI SI
BP 12
EP 12
PG 1
WC Clinical Neurology
SC Neurosciences & Neurology
GA 619BW
UT WOS:000279404600036
ER
PT J
AU Nickels, K
Hostalkova, P
Katusic, S
Weaver, A
Barbaresi, W
Wirrell, E
AF Nickels, K.
Hostalkova, P.
Katusic, S.
Weaver, A.
Barbaresi, W.
Wirrell, E.
TI THE FREQUENCY OF ABNORMAL EEGS AND EPILEPSY IN A POPULATION-BASED COHORT
OF CHILDREN WITH AUTISM IN ROCHESTER, MINNESOTA
SO EPILEPSIA
LA English
DT Meeting Abstract
CT 9th European Congress on Epileptology
CY JUN 27-JUL 01, 2010
CL Rhodes, GREECE
C1 [Nickels, K.; Hostalkova, P.; Katusic, S.; Weaver, A.; Barbaresi, W.; Wirrell, E.] Mayo Clin, Rochester, MN USA.
NR 0
TC 0
Z9 0
PU WILEY-BLACKWELL PUBLISHING, INC
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0013-9580
J9 EPILEPSIA
JI Epilepsia
PD JUN
PY 2010
VL 51
SU 4
SI SI
BP 103
EP 103
PG 1
WC Clinical Neurology
SC Neurosciences & Neurology
GA 619BW
UT WOS:000279404600347
ER
PT J
AU Monteiro, JP
Rocha, L
Duarte, A
Ventosa, L
Lourenco, L
Fonseca, MJ
AF Monteiro, J. P.
Rocha, L.
Duarte, A.
Ventosa, L.
Lourenco, L.
Fonseca, M. J.
TI EPILEPSY AND EEG ABNORMALITIES IN 104 CHILDREN WITH AUTISM SPECTRUM
DISORDERS
SO EPILEPSIA
LA English
DT Meeting Abstract
CT 9th European Congress on Epileptology
CY JUN 27-JUL 01, 2010
CL Rhodes, GREECE
C1 [Monteiro, J. P.; Rocha, L.; Duarte, A.; Ventosa, L.; Lourenco, L.; Fonseca, M. J.] Garcia Orta Hosp, Ctr Desenvolvimento Crianca Torrado Silva, Dept Pediat, Almada, Portugal.
NR 0
TC 0
Z9 0
PU WILEY-BLACKWELL PUBLISHING, INC
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0013-9580
J9 EPILEPSIA
JI Epilepsia
PD JUN
PY 2010
VL 51
SU 4
SI SI
BP 155
EP 155
PG 1
WC Clinical Neurology
SC Neurosciences & Neurology
GA 619BW
UT WOS:000279404600526
ER
PT J
AU Deonna, T
AF Deonna, T.
TI COGNITIVE DISTURBANCES INCLUDING AUTISM IN PATIENTS WITH CONTINUOUS
SPIKE-WAVE DURING SLOW SLEEP (CSWS)
SO EPILEPSIA
LA English
DT Meeting Abstract
CT 9th European Congress on Epileptology
CY JUN 27-JUL 01, 2010
CL Rhodes, GREECE
NR 0
TC 0
Z9 0
PU WILEY-BLACKWELL PUBLISHING, INC
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0013-9580
J9 EPILEPSIA
JI Epilepsia
PD JUN
PY 2010
VL 51
SU 4
SI SI
BP 171
EP 171
PG 1
WC Clinical Neurology
SC Neurosciences & Neurology
GA 619BW
UT WOS:000279404600577
ER
PT J
AU Sotillo, M
Lopez-Frutos, JM
Tripicchio, P
AF Sotillo, Maria
Lopez-Frutos, Jose Ma
Tripicchio, Paula
TI Attentional mechanisms in high-functioning autism: A review of the state
of the issue
SO ESTUDIOS DE PSICOLOGIA
LA Spanish
DT Review
DE Attention processes; ASD; high functioning autism
ID STIMULUS OVER-SELECTIVITY; AUDITORY INFORMATION; SHIFTING ATTENTION;
BRAIN POTENTIALS; CHILDREN; DEFICITS; IMPAIRMENT; NETWORKS; FIXATION;
DISORDER
AB The paper reviews theoretical approaches and empirical results from studies evaluating attentional processes in persons with autism spectrum disorders (ASD), specifically in the high cognitive functioning sub-type. Convergent results from different studies are pointed out and some contradictions between reported research results are discussed together with some possible explanations. Finally, the importance of studying attention in persons with ASD, from a conceptual, diagnostic and clinical viewpoint, is emphasised.
C1 [Sotillo, Maria] Univ Autonoma Madrid, Fac Psicol, Dept Psicol Basica, E-28049 Madrid, Spain.
[Tripicchio, Paula] INECO, Buenos Aires, DF, Argentina.
RP Sotillo, M (reprint author), Univ Autonoma Madrid, Fac Psicol, Dept Psicol Basica, E-28049 Madrid, Spain.
EM maria.sotillo@uam.es
RI Sotillo, Maria/N-4947-2014
OI Sotillo, Maria/0000-0002-9602-9216
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NR 50
TC 0
Z9 0
PU FUNDACION INFANCIA APRENDIZAJE
PI MADRID
PA NARANJO DE BULNES, 69 CIUDALCAMPO, SAN SEBASTIAN DE LOS REYES, MADRID,
28707, SPAIN
SN 0210-9395
J9 ESTUD PSICOL
JI Estud. Psicol.
PD JUN
PY 2010
VL 31
IS 2
BP 133
EP 143
PG 11
WC Psychology, Multidisciplinary
SC Psychology
GA 604RV
UT WOS:000278297100002
ER
PT J
AU Noterdaeme, M
Wriedt, E
Hohne, C
AF Noterdaeme, Michele
Wriedt, Elke
Hoehne, Christian
TI Asperger's syndrome and high-functioning autism: language, motor and
cognitive profiles
SO EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
LA English
DT Article
DE Asperger syndrome; High-functioning autism; Intelligence; Language
impairment; Motor disorder
ID PERVASIVE DEVELOPMENTAL DISORDERS; DIAGNOSTIC OBSERVATION SCHEDULE;
INDIVIDUALS; SPECTRUM; DEFICITS; CHILDREN
AB The objective of this study is to compare the cognitive profile, the motor and language functioning and the psychosocial adaptation of children with Asperger syndrome (AS) and with high-functioning autism (HFA). Subjects were recruited through the department Autism and Developmental Disorders of the Heckscher-Klinikum. To be included in the study, the full-scale-IQ had to be at least 80. Subjects with AS had to have a normal early language development and subjects with HFA a clear delay in language development, as reported by their parents. The sample consisted of 57 children with Asperger syndrome and 55 children with high-functioning autism. The mean age of the children was 10 years. All subjects were examined with a standardised test battery. Children with AS had a higher full-scale-IQ than children with HFA. This was due to a higher verbal-IQ. There were no significant differences in the performance-IQ. At a mean age of 10 years, subjects with AS had better language skills than subjects with HFA, but at least 30% showed clear receptive language problems. Motor problems were present in about 50% of the children with AS and HFA. The level of psychosocial adaptation was clearly reduced, but was comparable for the two groups. The differences in verbal-IQ and language skills between the two groups could be explained through the definition of the syndromes. The presence of language problems in the subjects with AS at age 10, the comparable degree of motor impairment and level of psychosocial adaptation question the validity of the distinction between AS and HFA within the category of pervasive developmental disorders.
C1 [Noterdaeme, Michele] Klin Kinder & Jugendpsychiat & Psychotherapie, D-86154 Augsburg, Germany.
[Wriedt, Elke; Hoehne, Christian] Heckscher Klinikum Kinder & Jugendpsychiat Psycho, D-81539 Munich, Germany.
RP Noterdaeme, M (reprint author), Klin Kinder & Jugendpsychiat & Psychotherapie, Kapellenstr 30, D-86154 Augsburg, Germany.
EM noterdaeme.michele@josefinum.de
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NR 35
TC 26
Z9 30
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1018-8827
J9 EUR CHILD ADOLES PSY
JI Eur. Child Adolesc. Psych.
PD JUN
PY 2010
VL 19
IS 6
BP 475
EP 481
DI 10.1007/s00787-009-0057-0
PG 7
WC Psychology, Developmental; Pediatrics; Psychiatry
SC Psychology; Pediatrics; Psychiatry
GA 602QH
UT WOS:000278153400002
PM 19813070
ER
PT J
AU Foss-Feig, JH
Kwakye, LD
Cascio, CJ
Burnette, CP
Kadivar, H
Stone, WL
Wallace, MT
AF Foss-Feig, Jennifer H.
Kwakye, Leslie D.
Cascio, Carissa J.
Burnette, Courtney P.
Kadivar, Haleh
Stone, Wendy L.
Wallace, Mark T.
TI An extended multisensory temporal binding window in autism spectrum
disorders
SO EXPERIMENTAL BRAIN RESEARCH
LA English
DT Article
DE Autism; Multisensory; Temporal binding; Audiovisual; Sensory processing;
Cross-modal integration
ID AUDIOVISUAL SPEECH INTEGRATION; DEVELOPMENTAL DISORDERS; SENSORY
PROFILE; YOUNG-CHILDREN; INDIVIDUALS; PERCEPTION; ADULTS;
DISCRIMINATION; ABNORMALITIES; INFORMATION
AB Autism spectrum disorders (ASD) form a continuum of neurodevelopmental disorders, characterized by deficits in communication and reciprocal social interaction, as well as by repetitive behaviors and restricted interests. Sensory disturbances are also frequently reported in clinical and autobiographical accounts. However, surprisingly few empirical studies have characterized the fundamental features of sensory and multisensory processing in ASD. The current study is structured to test for potential differences in multisensory temporal function in ASD by making use of a temporally dependent, low-level multisensory illusion. In this illusion, the presentation of a single flash of light accompanied by multiple sounds often results in the illusory perception of multiple flashes. By systematically varying the temporal structure of the audiovisual stimuli, a "temporal window" within which these stimuli are likely to be bound into a single perceptual entity can be defined. The results of this study revealed that children with ASD report the flash-beep illusion over an extended range of stimulus onset asynchronies relative to children with typical development, suggesting that children with ASD have altered multisensory temporal function. These findings provide valuable new insights into our understanding of sensory processing in ASD and may hold promise for the development of more sensitive diagnostic measures and improved remediation strategies.
C1 [Wallace, Mark T.] Vanderbilt Univ, Dept Hearing & Speech Sci, Nashville, TN 37232 USA.
[Foss-Feig, Jennifer H.; Cascio, Carissa J.; Stone, Wendy L.] Vanderbilt Univ, Dept Psychol & Human Dev, Nashville, TN 37232 USA.
[Kwakye, Leslie D.] Vanderbilt Univ, Grad Program Neurosci, Nashville, TN 37232 USA.
[Cascio, Carissa J.; Wallace, Mark T.] Vanderbilt Univ, Dept Psychiat, Nashville, TN 37232 USA.
[Cascio, Carissa J.; Burnette, Courtney P.; Kadivar, Haleh; Stone, Wendy L.; Wallace, Mark T.] Vanderbilt Univ, Vanderbilt Kennedy Ctr Res Human Dev, Nashville, TN 37232 USA.
[Burnette, Courtney P.; Stone, Wendy L.] Vanderbilt Univ, Dept Pediat, Nashville, TN 37232 USA.
[Wallace, Mark T.] Vanderbilt Univ, Dept Psychol, Nashville, TN 37232 USA.
[Cascio, Carissa J.; Wallace, Mark T.] Vanderbilt Univ, Vanderbilt Brain Inst, Nashville, TN 37232 USA.
RP Wallace, MT (reprint author), Vanderbilt Univ, Dept Hearing & Speech Sci, 7110 MRB 3,BioSci Bldg,465 21st Ave S, Nashville, TN 37232 USA.
EM mark.wallace@vanderbilt.edu
FU Marino Autism Research Institute; National Institute of Child Health and
Development [T32 HD07226]; Meharry-Vanderbilt Alliance; Vanderbilt
Kennedy Center
FX This work was supported by a Marino Autism Research Institute Discovery
Grant (PI: MTW); National Institute of Child Health and Development T32
HD07226 predoctoral fellowship for JHF; Meharry-Vanderbilt Alliance
Training Grant for LDK; Vanderbilt Kennedy Center.
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NR 49
TC 66
Z9 66
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0014-4819
J9 EXP BRAIN RES
JI Exp. Brain Res.
PD JUN
PY 2010
VL 203
IS 2
BP 381
EP 389
DI 10.1007/s00221-010-2240-4
PG 9
WC Neurosciences
SC Neurosciences & Neurology
GA 596VB
UT WOS:000277712500014
PM 20390256
ER
PT J
AU Stiegler, LN
Davis, R
AF Stiegler, Lillian N.
Davis, Rebecca
TI Understanding Sound Sensitivity in Individuals with Autism Spectrum
Disorders
SO FOCUS ON AUTISM AND OTHER DEVELOPMENTAL DISABILITIES
LA English
DT Article
DE autism spectrum disorders (ASD); sound sensitivity; hyperacusis;
auditory; [one phrase] hyperreactivity
ID CHILDREN; HYPERSENSITIVITY; HYPERACUSIS; COMMUNICATION; PHOBIAS; NOISE;
MODEL
AB Literature on sound sensitivity in individuals with and without autism spectrum disorders (ASD) is reviewed in this article. Empirical evidence is examined, and physiologic and psychoemotional-behavioral perspectives are described. There is virtually no evidence of true physiological differences in auditory systems of individuals with ASD. It is evident, however, that many people with ASD (a) feel fearful and anxious about sound, and (b) may experience unpleasant physiological sensations because of autonomic and/or behavioral responses to nonpreferred sounds, but (c) can learn to react in less stigmatizing, more effectively self-regulating ways. Current assessment and intervention practices are discussed, and a case is presented. Heightened understanding of this issue among caregivers and interventionists may ultimately improve life participation for individuals with ASD.
C1 [Stiegler, Lillian N.; Davis, Rebecca] SE Louisiana Univ, Hammond, LA 70402 USA.
RP Stiegler, LN (reprint author), Dept Commun Sci & Disorders, Box 10879SLU, Hammond, LA 70402 USA.
EM lstiegler@selu.edu
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American Speech-Language-Hearing Association, 2008, INC PREV HEAR LOSS H
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NR 54
TC 6
Z9 6
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1088-3576
J9 FOCUS AUTISM DEV DIS
JI Focus Autism Dev. Disabil.
PD JUN
PY 2010
VL 25
IS 2
BP 67
EP 75
DI 10.1177/1088357610364530
PG 9
WC Education, Special; Psychology, Developmental; Rehabilitation
SC Education & Educational Research; Psychology; Rehabilitation
GA 598JX
UT WOS:000277833500001
ER
PT J
AU Mechling, LC
Moser, SV
AF Mechling, Linda C.
Moser, Sara V.
TI Video Preference Assessment of Students with Autism for Watching Self,
Adults, or Peers
SO FOCUS ON AUTISM AND OTHER DEVELOPMENTAL DISABILITIES
LA English
DT Article
DE autism; video technology; self-modeling; other modeling; preference
assessment
ID TEACH PERSPECTIVE-TAKING; DAILY LIVING SKILLS; STIMULUS PREFERENCE;
IDENTIFYING REINFORCERS; MODELING INTERVENTIONS; CHILDREN; DISABILITIES;
PLAY; INDIVIDUALS; INSTRUCTION
AB The preferences of students with autism for watching themselves, a familiar adult, or a familiar peer in video recordings were examined. A multi-stimulus video preference assessment was used to evaluate the preferences of five students with autism. Three video options of a preferred activity (e. g., vacuuming) or daily/routine activity (e. g., snack time) were available to students via a computer-based program. Results showed that collectively there was minimal difference between the three video choices across the five students. However, in their individual scores, preferences varied among the students and activities, providing a framework for discussion of individual preference assessments when using video for instructional programs and reinforcement of task performance and behavior.
C1 [Mechling, Linda C.] Univ N Carolina, Wilmington, NC 28403 USA.
[Moser, Sara V.] Adams Elementary, Cary, NC USA.
RP Mechling, LC (reprint author), Univ N Carolina, 601 S Coll Rd, Wilmington, NC 28403 USA.
EM mechlingl@uncw.edu
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NR 43
TC 6
Z9 6
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1088-3576
J9 FOCUS AUTISM DEV DIS
JI Focus Autism Dev. Disabil.
PD JUN
PY 2010
VL 25
IS 2
BP 76
EP 84
DI 10.1177/1088357610364392
PG 9
WC Education, Special; Psychology, Developmental; Rehabilitation
SC Education & Educational Research; Psychology; Rehabilitation
GA 598JX
UT WOS:000277833500002
ER
PT J
AU Hartley, SL
Sikora, DM
AF Hartley, Sigan L.
Sikora, Darryn M.
TI Detecting Autism Spectrum Disorder in Children With Intellectual
Disability: Which DSM-IV-TR Criteria Are Most Useful?
SO FOCUS ON AUTISM AND OTHER DEVELOPMENTAL DISABILITIES
LA English
DT Article
DE autism; intellectual disability; evaluation; diagnosis; parent interview
ID MENTAL-RETARDATION; DIAGNOSTIC INTERVIEW; YOUNG-CHILDREN; ADI-R; EARLY
INTERVENTION; CHILDHOOD AUTISM; PARENT INTERVIEW; ADOLESCENTS; LANGUAGE;
CLASSIFICATION
AB The diagnosis of autism spectrum disorders (ASDs) in older children with intellectual disabilities (IDs) is challenging because of overlap in symptomatology and the high comorbidity of these disorders. On the basis of a sample of 89 older children with IDs (aged 6-15 years) referred to an ASD clinic, semistructured parent interviews were used to investigate the Diagnostic and Statistical Manual of Mental Disorders (4th ed., text rev.) diagnostic criteria that differentiated children with ASDs from those without ASDs. Diagnostic criteria related to impaired social interactions, stereotyped or idiosyncratic language, poor conversational skills, lack of pretend and imitative play, and restricted or narrowed interests were related to ASD diagnoses. The findings of this study have implications for improving ASD diagnostic evaluations in children with IDs.
C1 [Hartley, Sigan L.] Univ Wisconsin, Waisman Ctr, Lifespan Dev Lab, Madison, WI 53705 USA.
[Sikora, Darryn M.] Oregon Hlth & Sci Univ, Child Dev & Rehabil Ctr, Autism Clin, Portland, OR 97201 USA.
RP Hartley, SL (reprint author), Univ Wisconsin, Waisman Ctr, Lifespan Dev Lab, 1500 Highland Ave, Madison, WI 53705 USA.
EM hartley@waisman.wisc.edu
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NR 52
TC 3
Z9 3
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1088-3576
J9 FOCUS AUTISM DEV DIS
JI Focus Autism Dev. Disabil.
PD JUN
PY 2010
VL 25
IS 2
BP 85
EP 97
DI 10.1177/1088357609356094
PG 13
WC Education, Special; Psychology, Developmental; Rehabilitation
SC Education & Educational Research; Psychology; Rehabilitation
GA 598JX
UT WOS:000277833500003
ER
PT J
AU Jegatheesan, B
Miller, PJ
Fowler, SA
AF Jegatheesan, Brinda
Miller, Peggy J.
Fowler, Susan A.
TI Autism From a Religious Perspective: A Study of Parental Beliefs in
South Asian Muslim Immigrant Families
SO FOCUS ON AUTISM AND OTHER DEVELOPMENTAL DISABILITIES
LA English
DT Article
DE Muslim families; religion; autism
ID EARLY INTERVENTION; CONSTRUCTION; CHILDREN; ISRAEL
AB Three multilingual immigrant South Asian Muslim families who have children with autism were interviewed to ascertain their beliefs about autism. Data were drawn from interviews and conversations recorded during 17 months of ethnographic fieldwork in homes and community. Results indicate that families understood the task of raising a child with autism in religious terms. In keeping with the precepts of Islam, their overarching goal was to raise their children as normally as possible, incorporating them into ordinary social, linguistic, and religious practices at home and in the community. Parents strongly contested experts' understandings of autism, which they believed undermined rather than promoted their children's development. Findings have implications for multicultural teacher education and enhancing home, community, and school collaboration.
C1 [Jegatheesan, Brinda] Univ Washington, Seattle, WA 98195 USA.
[Miller, Peggy J.; Fowler, Susan A.] Univ Illinois, Urbana, IL 61801 USA.
RP Jegatheesan, B (reprint author), Univ Washington, 322 J Miller Hall,Box 353600, Seattle, WA 98195 USA.
EM brinda@u.washington.edu
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NR 44
TC 9
Z9 9
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1088-3576
J9 FOCUS AUTISM DEV DIS
JI Focus Autism Dev. Disabil.
PD JUN
PY 2010
VL 25
IS 2
BP 98
EP 109
DI 10.1177/1088357610361344
PG 12
WC Education, Special; Psychology, Developmental; Rehabilitation
SC Education & Educational Research; Psychology; Rehabilitation
GA 598JX
UT WOS:000277833500004
ER
PT J
AU Carbone, VJ
Morgenstern, B
Zecchin-Tirri, G
Kolberg, L
AF Carbone, Vincent J.
Morgenstern, Barry
Zecchin-Tirri, Gina
Kolberg, Laura
TI The Role of the Reflexive-Conditioned Motivating Operation (CMO-R)
During Discrete Trial Instruction of Children With Autism
SO FOCUS ON AUTISM AND OTHER DEVELOPMENTAL DISABILITIES
LA English
DT Article
DE motivating operations; establishing operations; autism; escape and
avoidance behavior; discrete trial instruction
ID INJURIOUS ESCAPE BEHAVIOR; ESTABLISHING OPERATIONS; FUNCTIONAL-ANALYSIS;
NEGATIVE REINFORCEMENT; SELF-INJURY; INTERSPERSED REQUESTS; DESTRUCTIVE
BEHAVIOR; RESPONSE EFFICIENCY; MAINTAINED BEHAVIOR; SLEEP-DEPRIVATION
AB The principle of motivation has resurfaced as an independent variable in the field of behavior analysis over the past 20 years. The increased interest is the result of refinements of the concept of the motivating operation and its application to the learning needs of persons with developmental disabilities. Notwithstanding the increased emphasis upon modification of motivating operations to reduce problem behavior, there is limited recognition of this important behavioral variable in autism treatment literature. An overview of antecedent-based instructional modifications that lead to a reduction of escape and avoidance behavior of children with autism during instruction is provided. An analysis of these instructional methods as motivating operations is proposed. A conceptually systematic analysis of the influence of instructional methods is offered as a tool for improving the selection and implementation of effective teaching procedures.
C1 [Carbone, Vincent J.; Zecchin-Tirri, Gina; Kolberg, Laura] Carbone Clin, Valley Cottage, NY 10989 USA.
[Morgenstern, Barry] Inst Profess Practice Inc, Woodbridge, CT USA.
RP Carbone, VJ (reprint author), Carbone Clin, 614 Corp Way,Suite 1, Valley Cottage, NY 10989 USA.
EM drvjc@aol.com
RI Carbone, Virginia/H-7750-2013
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NR 111
TC 2
Z9 2
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1088-3576
J9 FOCUS AUTISM DEV DIS
JI Focus Autism Dev. Disabil.
PD JUN
PY 2010
VL 25
IS 2
BP 110
EP 124
DI 10.1177/1088357610364393
PG 15
WC Education, Special; Psychology, Developmental; Rehabilitation
SC Education & Educational Research; Psychology; Rehabilitation
GA 598JX
UT WOS:000277833500005
ER
PT J
AU Silverman, C
AF Silverman, Chloe
TI 'Birdwatching and baby-watching': Niko and Elisabeth Tinbergen's
ethological approach to autism
SO HISTORY OF PSYCHIATRY
LA English
DT Article
DE autism spectrum disorders; autistic; childhood schizophrenia; Elisabeth
Tinbergen; ethology; holding therapy; motivational conflict; Niko
Tinbergen; psychoanalysis
ID BOWLBY,JOHN; MONKEYS; STRESS
AB Biographers have largely dismissed Nikolaas 'Niko' Tinbergen's late research into the causes and treatment of autism, describing it as a deviation from his previous work, influenced by his personal desires. They have pointed to the incoherence of Tinbergen's assertions about best practices for treating autism, his lack of experience with children with autism, and his apparent embracing of psychogenic theories that the medical research community had largely abandoned. While these critiques have value, it is significant that Tinbergen himself saw his research as a logical extension of his seminal findings in the field of ethology, the science of animal behaviour. The reception of his theories, both positive and negative, was due less to their strengths or faults than to the fact that Tinbergen had inserted himself into a pre-existing and acrimonious debate in the autism research community. Debates about the relative role of environmental and hereditary factors in the aetiology of autism, and the implications of both for the efficacy of different treatments, had political and material significance for the success of parent organizations' lobbying efforts and financial support for research programmes. Tinbergen's approach was welcomed and even championed by a significant minority, who saw no problem with his ideas or methods.
C1 Penn State Univ, STS Program, University Pk, PA 16803 USA.
RP Silverman, C (reprint author), Penn State Univ, STS Program, 102 Old Bot, University Pk, PA 16803 USA.
EM cbs14@psu.edu
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NR 35
TC 2
Z9 2
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0957-154X
J9 HIST PSYCHIATR
JI Hist. Psychiatr.
PD JUN
PY 2010
VL 21
IS 2
BP 176
EP 189
DI 10.1177/0957154X10367875
PG 14
WC History Of Social Sciences; Psychiatry
SC Social Sciences - Other Topics; Psychiatry
GA 608RZ
UT WOS:000278605000004
PM 21877371
ER
PT J
AU Arieff, Z
Kaur, M
Gameeldien, H
van der Merwe, L
Bajic, VB
AF Arieff, Zainunisha
Kaur, Mandeep
Gameeldien, Hajirah
van der Merwe, Lize
Bajic, Vladimir B.
TI 5-HTTLPR Polymorphism: Analysis in South African Autistic Individuals
SO HUMAN BIOLOGY
LA English
DT Article
DE SEROTONIN TRANSPORTER; 5-HTTLPR POLYMORPHISM; AUTISM; SELECTIVE
SEROTONIN REUPTAKE INHIBITORS (SSRIS); SOUTH AFRICAN POPULATIONS
ID SEROTONIN TRANSPORTER GENE; PROMOTER REGION POLYMORPHISM; SPECTRUM
DISORDERS; ASSOCIATION; VARIANTS; POPULATION; CHILDREN; SLC6A4;
HYPERSEROTONEMIA; GENOTYPE
AB The serotonin transporter promoter length polymorphism (5-hydroxytryptamine transporter length polymorphism; 5-HTTLPR) has long been implicated in autism and other psychiatric disorders. The use of selective serotonin reuptake inhibitors (SSRIs) has a positive effect on treating some symptoms of autism. The effects of these drugs vary in individuals because of the presence of the S or L allele of 5-HTTLPR. Studies performed on various autistic populations have found different allele frequencies for the L and S alleles. Allele frequencies and genotypes of the South African autistic populations (African, mixed, and Caucasian) were compared with matching South African ethnic control populations. The *S/*S genotype was found to be highly significantly associated with all the South African autistic ethnic populations. In the South African African population the *S/*S genotype was present in 7 (33%) of the autistic individuals but in none of the control subjects, yielding infinitely large odds of developing autism. The odds of developing autism with the *S/*S genotype compared to the *L/*L genotype increased 10.15-fold in the South African mixed group and 2.74-fold in the South African Caucasian population. The allele frequency of the South African autistic population was also compared with studies of other autistic populations around the world, and highly significant differences were found with the Japanese, Korean, and Indian population groups. The difference was not significant for the French, German, Israeli, Portuguese, and American groups. This is the first South African study of autistic individuals of different ethnic backgrounds that shows significant differences in allele and genotype frequencies of 5-HTTLPR. The results of this study open new avenues for investigating the role of transmission of the L and S alleles in families with autism in South Africa.
C1 [Arieff, Zainunisha; Gameeldien, Hajirah] Univ Western Cape, Dept Biotechnol, ZA-7535 Cape Town, South Africa.
[Kaur, Mandeep; Bajic, Vladimir B.] King Abdullah Univ Sci & Technol, Computat Biosci Res Ctr, Thuwal 239556900, Saudi Arabia.
[van der Merwe, Lize] MRC, Biostat Unit, ZA-7505 Tygerberg, South Africa.
[van der Merwe, Lize] Univ Western Cape, Dept Stat, ZA-7535 Cape Town, South Africa.
RP Arieff, Z (reprint author), Univ Western Cape, Dept Biotechnol, Private Bag X17, ZA-7535 Cape Town, South Africa.
RI Bajic, Vladimir/D-2810-2009
OI Bajic, Vladimir/0000-0001-5435-4750
FU National Research Foundation, South Africa [TTK2008050600011]; Autism
South Africa; University of the Western Cape
FX We would like to thank the National Research Foundation, South Africa
(Thuthuka grant TTK2008050600011), Autism South Africa, and the
University of the Western Cape for funds provided for this study. We
also want to thank the children, their parents, the school staff, and
volunteers of the Western Cape Education Department for their support
and involvement during the sample collection. We thank Luke Esau,
Lucinda Adonis, Muneera Davids, Zaida Dalvie, Cleo Williams, and all the
final-year biotechnology student volunteers who so willingly helped us
with the sample collection from the different schools.
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NR 29
TC 5
Z9 6
PU WAYNE STATE UNIV PRESS
PI DETROIT
PA 4809 WOODWARD AVE, DETROIT, MI 48201-1309 USA
SN 0018-7143
J9 HUM BIOL
JI Hum. Biol.
PD JUN
PY 2010
VL 82
IS 3
BP 291
EP 300
PG 10
WC Anthropology; Biology; Genetics & Heredity
SC Anthropology; Life Sciences & Biomedicine - Other Topics; Genetics &
Heredity
GA 734LK
UT WOS:000288335400003
PM 20649385
ER
PT J
AU Konrad, K
Eickhoff, SB
AF Konrad, Kerstin
Eickhoff, Simon B.
TI Is the ADHD Brain Wired Differently? A Review on Structural and
Functional Connectivity in Attention Deficit Hyperactivity Disorder
SO HUMAN BRAIN MAPPING
LA English
DT Article
DE connectivity; ADHD; fMRI; DTI
ID DEFAULT-MODE NETWORK; WHITE-MATTER ABNORMALITIES; ANTERIOR CINGULATE
CORTEX; LOW-BIRTH-WEIGHT; DEFICIT/HYPERACTIVITY DISORDER;
MAGNETIC-RESONANCE; INTERFERENCE CONTROL; DIFFUSION; CHILDREN;
ACTIVATION
AB In recent years, a change in perspective in etiological models of attention deficit hyperactivity disorder (ADHD) has occurred in concordance with emerging concepts in other neuropsychiatric disorders such as schizophrenia and autism. These models shift the focus of the assumed pathology from regional brain abnormalities to dysfunction in distributed network organization. In the current contribution, we report findings from functional connectivity studies during resting and task states, as well as from studies on structural connectivity using diffusion tensor imaging, in subjects with ADHD. Although major methodological limitations in analyzing connectivity measures derived from noninvasive in vivo neuroimaging still exist, there is convergent evidence for white matter pathology and disrupted anatomical connectivity in ADHD. In addition, dysfunctional connectivity during rest and during cognitive tasks has been demonstrated. However, the causality between disturbed white matter architecture and cortical dysfunction remains to be evaluated. Both genetic and environmental factors might contribute to disruptions in interactions between different brain regions. Stimulant medication not only modulates regionally specific activation strength but also normalizes dysfunctional connectivity, pointing to a predominant network dysfunction in ADHD. By combining a longitudinal approach with a systems perspective in ADHD in the future, it might be possible to identify at which stage during development disruptions in neural networks emerge and to delineate possible new endophenotypes of ADHD. Hum Brain Mapp 31:904-916, 2010. (C) 2010 Wiley-Liss, Inc.
C1 [Konrad, Kerstin] Rhein Westfal TH Aachen, Univ Hosp, Dept Child & Adolescent Psychiat & Psychotherapy, Child Neuropsychol Sect, Aachen, Germany.
[Konrad, Kerstin; Eickhoff, Simon B.] Res Ctr Juelich, Inst Neurosci & Med INM2 INM3, Julich, Germany.
[Eickhoff, Simon B.] Rhein Westfal TH Aachen, Dept Psychiat & Psychotherapy, Univ Hosp, Aachen, Germany.
RP Konrad, K (reprint author), Rhein Westfal TH Aachen, Univ Hosp, Dept Child & Adolescent Psychiat & Psychotherapy, Child Neuropsychol Sect, Aachen, Germany.
EM kkonrad@ukaachen.de
RI Konrad, Kerstin/H-7747-2013
OI Konrad, Kerstin/0000-0001-9039-2615
FU German Federal Ministry of Education and Science [BMBF-EDNET-01GV0602,
BMBF-ANAC-01GJ0808]; Human Brain Project [NTH R01-MH074457-01A1];
Excellence Initiative of the German federal and state governments;
Helmholz Initiative on Systems-Biology
FX Contract grant sponsor: German Federal Ministry of Education and Science
(for K.K.); Contract grant numbers: BMBF-EDNET-01GV0602,
BMBF-ANAC-01GJ0808; Contract grant sponsor: Human Brain Project (for
S.B.E.); Contract grant number: NTH R01-MH074457-01A1; Contract grant
sponsors: Excellence Initiative of the German federal and state
governments (JARA-Seed fund) for K.K.; the Helmholz Initiative on
Systems-Biology "The Human Brain Model" for S.B.E.
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NR 74
TC 138
Z9 140
PU WILEY-LISS
PI HOBOKEN
PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 1065-9471
J9 HUM BRAIN MAPP
JI Hum. Brain Mapp.
PD JUN
PY 2010
VL 31
IS 6
SI SI
BP 904
EP 916
DI 10.1002/hbm.21058
PG 13
WC Neurosciences; Neuroimaging; Radiology, Nuclear Medicine & Medical
Imaging
SC Neurosciences & Neurology; Radiology, Nuclear Medicine & Medical Imaging
GA 605IM
UT WOS:000278341200008
PM 20496381
ER
PT J
AU Shaw, P
Gogtay, N
Rapoport, J
AF Shaw, Philip
Gogtay, Nitin
Rapoport, Judith
TI Childhood Psychiatric Disorders as Anomalies in Neurodevelopmental
Trajectories
SO HUMAN BRAIN MAPPING
LA English
DT Article
DE magnetic resonance imaging; child development; childhood psychiatric
disorders; modeling
ID ATTENTION-DEFICIT/HYPERACTIVITY DISORDER;
DEFICIT-HYPERACTIVITY-DISORDER; CORTICAL BRAIN-DEVELOPMENT; ONSET
SCHIZOPHRENIA; DOWNS-SYNDROME; UNAFFECTED SIBLINGS; ADHD; AUTISM;
METAANALYSIS; CHILDREN
AB Childhood psychiatric disorders are rarely static; rather they change over time and longitudinal studies are ideally suited to capture such dynamic processes. Using longitudinal data, insights can be gained into the nature of the perturbation away from the trajectory of typical development in childhood disorders. Thus, some disorders may reflect a delay in neurodevelopmental trajectories. Our studies in children with attention-deficit/hyperactivity disorder (ADHD) suggest that cortical development is delayed with a rightward shift along the age axis in cortical trajectories, most prominent in prefrontal cortical regions. Other disorders may be characterized by differences in the velocity of trajectories: the basic shape of neurodevelopmental curves remains intact, but with disrupted tempo. Thus, childhood onset schizophrenia is associated with a marked increase during adolescence in the velocity of loss of cerebral gray matter. By contrast, in childhood autism there is an early acceleration of brain growth, which overshoots typical dimensions leading to transient cerebral enlargement. Finally, there may be more profound deviations from typical neurodevelopment, with a complete "derailing" of brain growth and a loss of the features which characterize typical brain development. An example is the almost complete silencing of white matter growth during adolescence of patients with childhood onset schizophrenia. Adopting a longitudinal perspective also readily lends itself to the understanding of the neural bases of differential clinical outcomes. Again taking ADHD as an example, we found that remission is associated with convergence to the template of typical development, whereas persistence is accompanied by progressive divergence away from typical trajectories. Plum Brain Mapp 31:917-925,2010. (C) 2010 Wiley-Liss, Inc.
C1 [Shaw, Philip; Gogtay, Nitin; Rapoport, Judith] NIMH, Child Psychiat Branch, Bethesda, MD 20892 USA.
RP Shaw, P (reprint author), NIMH, Child Psychiat Branch, Room 3N202,Bldg 10,Ctr Dr, Bethesda, MD 20892 USA.
EM shawp@mail.nih.gov
RI Gogtay, Nitin/A-3035-2008
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Walsh T, 2008, SCIENCE, V320, P539, DOI 10.1126/science.1155174
NR 57
TC 62
Z9 64
PU WILEY-LISS
PI HOBOKEN
PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 1065-9471
J9 HUM BRAIN MAPP
JI Hum. Brain Mapp.
PD JUN
PY 2010
VL 31
IS 6
SI SI
BP 917
EP 925
DI 10.1002/hbm.21028
PG 9
WC Neurosciences; Neuroimaging; Radiology, Nuclear Medicine & Medical
Imaging
SC Neurosciences & Neurology; Radiology, Nuclear Medicine & Medical Imaging
GA 605IM
UT WOS:000278341200009
PM 20496382
ER
PT J
AU Ayres, K
Cihak, D
AF Ayres, Kevin
Cihak, David
TI Computer- and Video-Based Instruction of Food-Preparation Skills:
Acquisition, Generalization, and Maintenance
SO INTELLECTUAL AND DEVELOPMENTAL DISABILITIES
LA English
DT Article
ID INTELLECTUAL DISABILITIES; ADOLESCENTS; STUDENTS; AUTISM
AB The purpose of this study was to evaluate the effects of a computer-based video instruction (CBVI) program to teach life skills. Three middle school aged students with intellectual disabilities were taught how to make a sandwich, use a microwave, and set the table with a CBVI software package. A multiple probe across behaviors design was used to evaluate for a functional relation between the software and skill acquisition. All students increased the percentage of steps completed in the correct order after receiving CBVI. During maintenance probes, the performance of all students deteriorated; after a single review session with CBVI, all students regained previous levels of performance, tentatively indicating a role of CBVI as a tool for reviewing previously mastered material. Results are discussed in terms of the use of CBVI for providing students sufficient learning trials on tasks that require the use of consumable products (e.g., food).
C1 [Ayres, Kevin] Univ Georgia, Athens, GA 30606 USA.
[Cihak, David] Univ Tennessee, Knoxville, TN 37996 USA.
RP Ayres, K (reprint author), Univ Georgia, Athens, GA 30606 USA.
EM kayres@uga.edu
CR Ayres Kevin M., 2007, Journal of Special Education Technology, V22
Ayres KM, 2006, EDUC TRAIN DEV DISAB, V41, P253
Ayres K. M., 2002, J SPECIAL ED TECHNOL, V17, P15
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*SANDB LEARN CO, I CAN DAIL LIV COMM
Sparrow S, 1984, VINELAND ADAPTIVE BE
Tam SF, 2005, REHABIL PSYCHOL, V50, P285, DOI 10.1037/0090-5550.50.3.285
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WISSICK CA, 1992, J SPECIAL ED TECHNOL, V11, P207
NR 21
TC 6
Z9 6
PU AMER ASSOC INTELLECTUAL DEVELOPMENTAL DISABILITIES
PI WASHINGTON
PA 444 N CAPITOL ST, NW STE 846, WASHINGTON, DC 20001-1512 USA
SN 1934-9491
J9 INTELLECT DEV DISAB
JI Intellect. Dev. Disabil.
PD JUN
PY 2010
VL 48
IS 3
BP 195
EP 208
DI 10.1352/1944-7558-48.3.195
PG 14
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA 619NI
UT WOS:000279436500003
PM 20597730
ER
PT J
AU Jordan, CJ
AF Jordan, Chloe J.
TI Evolution of Autism Support and Understanding Via the World Wide Web
SO INTELLECTUAL AND DEVELOPMENTAL DISABILITIES
LA English
DT Editorial Material
ID HIGH-FUNCTIONING AUTISM; ASPERGER-SYNDROME; NORMAL ADULTS; CHILDREN;
PARENTS; MIND
C1 Boston Univ, Dept Psychol, Lab Dev Cognit Neurosci, Boston, MA 02215 USA.
RP Jordan, CJ (reprint author), Boston Univ, Dept Psychol, Lab Dev Cognit Neurosci, 64 Cummington St, Boston, MA 02215 USA.
EM chloejen@bu.edu
CR ANNELLO B, 2006, AUTISM PETITION FUND
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Asperger H., 1991, AUTISM ASPERGER SYND, P37, DOI 10.1017/CBO9780511526770.002
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2009, AUTISM REALITY SHOW, V2
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NR 37
TC 11
Z9 11
PU AMER ASSOC INTELLECTUAL DEVELOPMENTAL DISABILITIES
PI WASHINGTON
PA 444 N CAPITOL ST, NW STE 846, WASHINGTON, DC 20001-1512 USA
SN 1934-9491
J9 INTELLECT DEV DISAB
JI Intellect. Dev. Disabil.
PD JUN
PY 2010
VL 48
IS 3
BP 220
EP 227
DI 10.1352/1934-9556-48.3.220
PG 8
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA 619NI
UT WOS:000279436500006
PM 20597733
ER
PT J
AU Rossetti, ZS
AF Rossetti, Zachary S.
TI Autism & the Transition to Adulthood: Success Beyond the Classroom
SO INTELLECTUAL AND DEVELOPMENTAL DISABILITIES
LA English
DT Book Review
C1 [Rossetti, Zachary S.] Providence Coll, Dept Educ, Providence, RI 02918 USA.
RP Rossetti, ZS (reprint author), Providence Coll, Dept Educ, Harkins 332,1 Cunningham Sq, Providence, RI 02918 USA.
EM zrossett@providence.edu
CR DONNELLAN AM, 1995, MOVEMENT DIFFERENCES
DUNN W, 2008, LEARNERS AUTISM SPEC, P138
GILLINGHAM G, 1995, AUTISM HANDLE CARE
GILLINGHAM G, 2000, AUTISM NEW UNDERSTAN
Kluth P., 2003, YOURE GOING LOVE THI
McGee J. P., 2001, ED CHILDREN AUTISM
Wehman P, 2009, AUTISM TRANSITION AD
NR 7
TC 0
Z9 0
PU AMER ASSOC INTELLECTUAL DEVELOPMENTAL DISABILITIES
PI WASHINGTON
PA 444 N CAPITOL ST, NW STE 846, WASHINGTON, DC 20001-1512 USA
SN 1934-9491
J9 INTELLECT DEV DISAB
JI Intellect. Dev. Disabil.
PD JUN
PY 2010
VL 48
IS 3
BP 228
EP 230
DI 10.1352/1934-9556-48.3.228
PG 3
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA 619NI
UT WOS:000279436500007
ER
PT J
AU Buckareff, AA
Van Wagenen, JS
AF Buckareff, Andrei A.
Van Wagenen, Joel S.
TI Surviving resurrection
SO INTERNATIONAL JOURNAL FOR PHILOSOPHY OF RELIGION
LA English
DT Article
DE Resurrection; Personal identity; Persons; Constitution; Lynne Rudder
Baker; Metaphysics
ID AUTISM; EMPATHY
AB In this paper we examine and critique the constitution view of the metaphysics of resurrection developed and defended by Lynne Rudder Baker. Baker identifies three conditions for an adequate metaphysics of resurrection. We argue that one of these, the identity condition, cannot be met on the constitution view given the account of personal identity it assumes. We discuss some problems with the constitution theory of personal identity Baker develops in her book, Persons and Bodies. We argue that these problems render the constitution theory of personal identity as stated by Baker untenable. The upshot for the debate over the metaphysics of resurrection is that the constitution view of the metaphysics of resurrection must either be rejected or modified.
C1 [Buckareff, Andrei A.] Marist Coll, Dept Philosophy & Religious Studies, Poughkeepsie, NY 12601 USA.
[Van Wagenen, Joel S.] Seton Hall Univ, John C Whitehead Sch Diplomacy & Int Relat, S Orange, NJ 07079 USA.
RP Buckareff, AA (reprint author), Marist Coll, Dept Philosophy & Religious Studies, Poughkeepsie, NY 12601 USA.
EM andrei.buckareff@marist.edu; jsvanwagenen@gmail.com
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Olson E., 1997, HUMAN ANIMAL
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NR 24
TC 0
Z9 0
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0020-7047
J9 INT J PHILOS RELIG
JI Int. J. Philos. Relig.
PD JUN
PY 2010
VL 67
IS 3
BP 123
EP 139
DI 10.1007/s11153-009-9222-0
PG 17
WC Philosophy; Religion
SC Philosophy; Religion
GA 610MU
UT WOS:000278737900001
ER
PT J
AU Bhanja, S
Mohanakumar, KP
AF Bhanja, Shravani
Mohanakumar, Kochupurackal P.
TI Early-life treatment of antiserotonin antibodies alters sensitivity to
serotonin receptors, nociceptive stimulus and serotonin metabolism in
adult rats
SO INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE
LA English
DT Article
DE Tremor; Pain; Dopamine; Nucleus raphe; Immunization against autism
spectrum disorders Hyperserotoninemia; CNS 5-HT development
ID CENTRAL-NERVOUS-SYSTEM; BRAIN-DEVELOPMENT; BALB/C MICE; BLOOD SEROTONIN;
INDUCED TREMOR; AUTISM; SCHIZOPHRENIA; PHYSOSTIGMINE; INVOLVEMENT;
CHILDREN
AB A single systemic administration of serotonin (5-HT) antibodies on day-1 of the life of rat has been investigated for neurotransmitter contents in nucleus raphe, and several discrete brain regions, as well as for serotoninergic syndromes and nociceptive responses in adult animals. 5-HT antiserum raised in rabbits were purified and characterized prior to subcutaneous administration in neonatal rats. Control animals received normal rabbit serum. Antibodies tagged with radioactive iodine were traced in the brains of rat pups treated subcutaneously.These animals at adulthood, exhibited an increase in body weight, increased sensitivity to serotonin agonist 5-methoxy-N-N-dimethyl tryptamine, and to nociceptive stimulus to subcutaneously administered formalin. Animals neonatally treated with 5-HT antiserum once on day 1 of life, exhibited significant decrease in the contents of serotonin and its metabolite as compared to normal serum treated animals specifically in nucleus raphe dorsalis, but not in substantia gresia centralis, nucleus accumbens, nucleus caudatus putamen, substantia nigra or tuberculum olfactorium during the study period of seven days to four months. The contents of dopamine or norepinephrine were not consistently altered in any of the nuclei studied. Since 5-HT is known to act as a trophic factor for its own development and its target areas, exposure to 5-HT antibodies during birth might have adversely affected the development of the serotoninergic system and resulted in long-lasting changes in behavior and 5-HT levels in the brain. These results have strong implications for the treatment of childhood developmental disorders such as autism where hyperserotoninemia is associated with the disease syndromes. (C) 2010 ISDN. Published by Elsevier Ltd. All rights reserved.
C1 [Mohanakumar, Kochupurackal P.] Indian Inst Chem Biol, Div Cell Biol & Physiol, Lab Clin & Expt Neurosci, CSIR, Kolkata 700032, W Bengal, India.
RP Mohanakumar, KP (reprint author), Indian Inst Chem Biol, Div Cell Biol & Physiol, Lab Clin & Expt Neurosci, CSIR, 4 Raja SC Mullick Rd, Kolkata 700032, W Bengal, India.
EM mohankumar@iicb.res.in
FU Department of Science and Technology, Govt. of India; CSIR, Govt. of
India
FX The study was funded by a project grant (to KPM) from Department of
Science and Technology, Govt. of India. S. Bhanja (nee Mohanty) received
junior and senior research fellowships from CSIR, Govt. of India.
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NR 70
TC 4
Z9 4
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0736-5748
EI 1873-474X
J9 INT J DEV NEUROSCI
JI Int. J. Dev. Neurosci.
PD JUN
PY 2010
VL 28
IS 4
BP 317
EP 324
DI 10.1016/j.ijdevneu.2010.02.007
PG 8
WC Developmental Biology; Neurosciences
SC Developmental Biology; Neurosciences & Neurology
GA 615KS
UT WOS:000279134800006
PM 20188813
ER
PT J
AU Johnstone, SJ
Watt, AJ
Dimoska, A
AF Johnstone, Stuart J.
Watt, Annele J.
Dimoska, Aneta
TI Varying required effort during interference control in children with
AD/HD: Task performance and ERPs
SO INTERNATIONAL JOURNAL OF PSYCHOPHYSIOLOGY
LA English
DT Article
DE Attention-deficit hyperactivity disorder; Children; Inhibition;
Interference control; ERPs; Effort; N200; Arousal
ID ATTENTION-DEFICIT/HYPERACTIVITY-DISORDER; DEFICIT HYPERACTIVITY
DISORDER; EVENT-RELATED POTENTIALS; AUTISM SPECTRUM DISORDERS;
COGNITIVE-ENERGETIC MODEL; RESPONSE-INHIBITION; SUSTAINED ATTENTION;
SELECTIVE ATTENTION; STATE-REGULATION; ERROR-DETECTION
AB Prominent models of attention-deficit/hyperactivity disorder (AD/HD) contend that disinhibition is the core deficit, or that any inhibition deficits that exist are secondary to dysfunctional energetic regulation (i.e. effort and arousal). This study tested these models by investigating the influence of task-directed effort, as manipulated by stimulus degradation, on interference control deficits in children with AD/HD. Twenty children with AD/HD aged between 7 and 14 years were matched in age to 20 controls and performed a modified visual Eriksen flanker task, while EEG and skin conductance level (SCL) were recorded. Participants completed the task under three conditions varying in stimulus degradation: none, 30% or 60%. Results revealed a quadratic effect with improved task performance in the 30% degradation condition, relative to the other conditions. Overall, children with AD/HD showed a tendency towards increased errors and more variable responding, although this did not differ between conditions. Importantly, children with AD/HD showed no deficits in interference control at a behavioural level. SCL revealed reduced activity in the AD/HD group during the non-degraded condition which normalised to control levels in the highest degradation condition. ERPs revealed two functionally distinct N2 components, one of which, along with the P3, was larger to incongruent stimuli, consistent with previous studies linking this component to inhibitory processing. Atypical activation of these components was evident in children with AD/HD and occurred as a function of degradation condition. Taken together these findings suggest the role of other factors such as state regulation as underlying deficits in AD/HD. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Johnstone, Stuart J.; Watt, Annele J.; Dimoska, Aneta] Univ Wollongong, Sch Psychol, Brain & Behav Res Inst, Wollongong, NSW 2522, Australia.
RP Johnstone, SJ (reprint author), Univ Wollongong, Sch Psychol, Brain & Behav Res Inst, Wollongong, NSW 2522, Australia.
EM sjohnsto@uow.edu.au
FU Australian Research Council [DP0559048]
FX This study was supported by a grant to SJJ from the Australian Research
Council Discovery funding scheme (DP0559048).
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NR 77
TC 11
Z9 13
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0167-8760
J9 INT J PSYCHOPHYSIOL
JI Int. J. Psychophysiol.
PD JUN
PY 2010
VL 76
IS 3
BP 174
EP 185
DI 10.1016/j.ijpsycho.2010.03.010
PG 12
WC Psychology, Biological; Neurosciences; Physiology; Psychology;
Psychology, Experimental
SC Psychology; Neurosciences & Neurology; Physiology
GA 609YS
UT WOS:000278695400007
PM 20362016
ER
PT J
AU Ghanizadeh, A
AF Ghanizadeh, Ahmad
TI Clinical Approach to Motor Stereotypies in Autistic Children
SO IRANIAN JOURNAL OF PEDIATRICS
LA English
DT Article
DE Motor; Stereotypy; Autism; Clinical Approach; Children
ID PERVASIVE DEVELOPMENTAL DISORDERS; HIGH-FUNCTIONING AUTISM;
OBSESSIVE-COMPULSIVE DISORDER; SELF-INJURIOUS-BEHAVIOR; REPETITIVE
BEHAVIORS; SPECTRUM DISORDERS; DOUBLE-BLIND; YOUNG-CHILDREN; NONAUTISTIC
CHILDREN; MENTAL-RETARDATION
AB This is an overview of stereotypic behavior in autistic spectrum disorder (ASD). This repetitive, nonfunctional, fixed pattern of behavior is associated with autism severity but it is not specific for ASD. There are a wide range of behaviors mentioned as stereotypies. It usually starts in early childhood and its severity is associated with outcomes and severity of autism in adolescence and adulthood. It is usually co-morbid with other psychiatric problems and its pathophysiology is not exactly known. Management is most likely behavioral. There are some reports regarding efficacy of antipsychotics for its management. Further studies should be conducted to improve our knowledge about it and our ability to differentiate it from tics.
C1 [Ghanizadeh, Ahmad] Shiraz Univ Med Sci, Res Ctr Psychiat & Behav Sci, Hafez Hosp, Shiraz, Iran.
[Ghanizadeh, Ahmad] Shiraz Univ Med Sci, Dept Psychiat, Shiraz, Iran.
RP Ghanizadeh, A (reprint author), Shiraz Univ Med Sci, Res Ctr Psychiat & Behav Sci, Hafez Hosp, Shiraz, Iran.
EM ghanizad@sina.tums.ac.ir
RI Ghanizadeh, Ahmad/C-2177-2011
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NR 94
TC 2
Z9 2
PU IRANIAN SCIENTIFIC SOCIETY MEDICAL ENTOMOLOGY
PI TEHRAN
PA SCHOOL PUBLIC HEALTH & INST HEALTH RESEARCH, TEHRAN UNIV MEDICAL
SCIENCES, P O BOX 6446-14155, TEHRAN, 00000, IRAN
SN 2008-2142
J9 IRAN J PEDIATR
JI Iran. J. Pediatr.
PD JUN
PY 2010
VL 20
IS 2
BP 149
EP 159
PG 11
WC Pediatrics
SC Pediatrics
GA 618AT
UT WOS:000279324200001
PM 23056697
ER
PT J
AU Lim, B
Shah, N
Ennis, S
Shields, DC
AF Lim, B.
Shah, N.
Ennis, S.
Shields, D. C.
TI COPY NUMBER VARIATIONS IN AUTISM
SO IRISH JOURNAL OF MEDICAL SCIENCE
LA English
DT Meeting Abstract
C1 [Lim, B.; Shah, N.; Ennis, S.; Shields, D. C.] Hlth Sci Ctr, UCD Sch Med & Med Sci, Dublin 4, Ireland.
[Shields, D. C.] Conway Inst Biomol & Biomed Sci, UCD Complex & Adapt Syst Lab, Dublin 4, Ireland.
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NR 2
TC 0
Z9 0
PU SPRINGER LONDON LTD
PI LONDON
PA 236 GRAYS INN RD, 6TH FLOOR, LONDON WC1X 8HL, ENGLAND
SN 0021-1265
J9 IRISH J MED SCI
JI Irish J. Med. Sci.
PD JUN
PY 2010
VL 179
SU 6
MA 8
BP S278
EP S278
PG 1
WC Medicine, General & Internal
SC General & Internal Medicine
GA 651UO
UT WOS:000281952900009
ER
PT J
AU Mc Sweeney, N
Johnson, N
Moore, W
Robinson, R
AF Mc Sweeney, N.
Johnson, N.
Moore, W.
Robinson, R.
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LA English
DT Meeting Abstract
C1 [Mc Sweeney, N.; Robinson, R.] Great Ormond St Hosp Sick Children, Dept Paediat Neurol, London, England.
[Moore, W.] Great Ormond St Hosp Sick Children, Dept Ophthalmol, London, England.
NR 0
TC 0
Z9 0
PU SPRINGER LONDON LTD
PI LONDON
PA 236 GRAYS INN RD, 6TH FLOOR, LONDON WC1X 8HL, ENGLAND
SN 0021-1265
J9 IRISH J MED SCI
JI Irish J. Med. Sci.
PD JUN
PY 2010
VL 179
SU 5
BP S266
EP S266
PG 1
WC Medicine, General & Internal
SC General & Internal Medicine
GA 651UL
UT WOS:000281952600250
ER
PT J
AU Wiwanitkit, V
AF Wiwanitkit, Viroj
TI Thai Massage and Autism: Correlation?
SO JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE
LA English
DT Letter
RP Wiwanitkit, V (reprint author), Wiwanitkit House, Bangkok 10160, Thailand.
EM wviroj@yahoo.com
CR Piravej K, 2009, J ALTERN COMPLEM MED, V15, P1355, DOI 10.1089/acm.2009.0258
NR 1
TC 0
Z9 0
PU MARY ANN LIEBERT INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1075-5535
J9 J ALTERN COMPLEM MED
JI J. Altern. Complement Med.
PD JUN
PY 2010
VL 16
IS 6
BP 613
EP 613
DI 10.1089/acm.2010.0024
PG 1
WC Integrative & Complementary Medicine
SC Integrative & Complementary Medicine
GA 614CR
UT WOS:000279033300003
PM 20569025
ER
PT J
AU Piravej, K
AF Piravej, Krisna
TI Reply to "Thai Massage and Autism: Correlation?''
SO JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE
LA English
DT Letter
C1 Chulalongkorn Univ, Dept Rehabil Med, Fac Med, Bangkok 10330, Thailand.
RP Piravej, K (reprint author), Chulalongkorn Univ, Dept Rehabil Med, Fac Med, Bangkok 10330, Thailand.
EM knpiravej@hotmail.com
CR Piravej K, 2009, J ALTERN COMPLEM MED, V15, P1355, DOI 10.1089/acm.2009.0258
NR 1
TC 0
Z9 0
PU MARY ANN LIEBERT INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1075-5535
J9 J ALTERN COMPLEM MED
JI J. Altern. Complement Med.
PD JUN
PY 2010
VL 16
IS 6
BP 615
EP 615
DI 10.1089/acm.2010.0118
PG 1
WC Integrative & Complementary Medicine
SC Integrative & Complementary Medicine
GA 614CR
UT WOS:000279033300004
ER
PT J
AU Meguid, NA
Hashish, AF
Anwar, M
Sidhom, G
AF Meguid, Nagwa A.
Hashish, Adel F.
Anwar, Mona
Sidhom, Gloria
TI Reduced Serum Levels of 25-Hydroxy and 1,25-Dihydroxy Vitamin D in
Egyptian Children with Autism
SO JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE
LA English
DT Article
ID D DEFICIENCY; CHRONIC DISEASES; OLDER-ADULTS; BRAIN; DISORDERS; SYSTEM;
HEALTH; RATS; PREVALENCE; EXPRESSION
AB Objective: The aim of this study was to investigate the potential role of vitamin D in autism through serum level assessment.
Design: This was a case-controlled cross-sectional study.
Setting: The study was conducted at the Out-patient Clinic for "Children with Special Needs'' at the Medical Services Unit of the National Research Centre in Cairo, Egypt.
Subjects: Seventy (70) children with autism diagnosed according to the DSM-IV criteria of the American Psychiatric Association were recruited for this study. The mean age +/- standard deviation (SD) of the patients was 5.3 +/- 2.8 years. Controls included 42 age-matched randomly selected healthy children of the same socioeconomic status (mean age +/- SD, 6.1 +/- 1.8 years).
Methods: Circulating levels of both forms of vitamin D (25(OH)D and 1,25(OH)(2)D) and serum calcium were measured for all subjects. Associations between vitamin D status, birth season, and clinical characteristics of autism were examined.
Results: Children with autism had significantly lower 25(OH)D (p< 0.00001) and 1,25(OH)(2)D (p< 0.005) as well as lower calcium (p< 0.0001) serum values than the controls. A significant positive correlation was obtained between 25(OH)D and calcium (correlation coefficient r- 0.309, p< 0.01) within the children with autism. No significant difference was found on comparison of birth month and season of birth between children with autism and healthy controls. Furthermore, associations linking parental consanguinity or convulsions with vitamin D could not be established.
Conclusions: Serum values of 25(OH)D in the children with autism of this study could classify them as being "vitamin D inadequate,'' which lends support to the hypothesis that autism is a vitamin D deficiency disorder.
C1 [Sidhom, Gloria] Natl Res Ctr, Dept Clin & Chem Pathol, Cairo 11771, Egypt.
[Meguid, Nagwa A.; Hashish, Adel F.; Anwar, Mona] Natl Res Ctr, Dept Res Children Special Needs, Cairo 11771, Egypt.
RP Sidhom, G (reprint author), Natl Res Ctr, Dept Clin & Chem Pathol, POB 5216,Heliopolis W, Cairo 11771, Egypt.
EM gloriasidhom@yahoo.com
FU National Research Centre in Cairo, Egypt
FX The authors would like to thank the National Research Centre in Cairo,
Egypt for their financial support.
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NR 44
TC 23
Z9 27
PU MARY ANN LIEBERT INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1075-5535
J9 J ALTERN COMPLEM MED
JI J. Altern. Complement Med.
PD JUN
PY 2010
VL 16
IS 6
BP 641
EP 645
DI 10.1089/acm.2009.0349
PG 5
WC Integrative & Complementary Medicine
SC Integrative & Complementary Medicine
GA 614CR
UT WOS:000279033300009
PM 20569030
ER
PT J
AU Leaf, JB
Sheldon, JB
Sherman, JA
AF Leaf, Justin B.
Sheldon, Jan B.
Sherman, James A.
TI COMPARISON OF SIMULTANEOUS PROMPTING AND NO-NO PROMPTING IN TWO-CHOICE
DISCRIMINATION LEARNING WITH CHILDREN WITH AUTISM
SO JOURNAL OF APPLIED BEHAVIOR ANALYSIS
LA English
DT Article
DE autism; discrete-trial teaching; no-no prompting; simultaneous prompting
ID ERROR-CORRECTION; DEVELOPMENTAL-DISABILITIES; INDIVIDUALS; ACQUISITION;
INSTRUCTION; PREFERENCE; STUDENTS; SKILLS; TASKS
AB This study compared no-no prompting procedures to simultaneous prompting procedures for 3 children with autism. Using a parallel treatments design, researchers taught rote math skills, receptive labels, or answers to "wh-" questions with both prompting systems. Results indicated that no-no prompting was effective in teaching all skills. By contrast, simultaneous prompting was effective in teaching only one pair of skills to 1 participant in the same amount of teaching time and trials. Researchers conducted a preference assessment to determine which of the two prompting procedures the 3 participants preferred. The participants showed mixed preferences for the two procedures.
C1 [Leaf, Justin B.] Univ Kansas, Dept Appl Behav Sci, Lawrence, KS 66045 USA.
RP Leaf, JB (reprint author), Univ Kansas, Dept Appl Behav Sci, 1000 Sunnyside Ave,Room 4001, Lawrence, KS 66045 USA.
EM leafku@ku.edu
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NR 34
TC 13
Z9 13
PU JOURNAL APPL BEHAV ANAL
PI LAWRENCE
PA DEPT HUMAN DEVELOPMENT, UNIV KANSAS, LAWRENCE, KS 66045 USA
SN 0021-8855
J9 J APPL BEHAV ANAL
JI J. Appl. Behav. Anal.
PD SUM
PY 2010
VL 43
IS 2
BP 215
EP 228
DI 10.1901/jaba.2010.43-215
PG 14
WC Psychology, Clinical
SC Psychology
GA 610YI
UT WOS:000278776300003
PM 21119896
ER
PT J
AU Napolitano, DA
Smith, T
Zarcone, JR
Goodkin, K
McAdam, DB
AF Napolitano, Deborah A.
Smith, Tristram
Zarcone, Jennifer R.
Goodkin, Karen
McAdam, David B.
TI INCREASING RESPONSE DIVERSITY IN CHILDREN WITH AUTISM
SO JOURNAL OF APPLIED BEHAVIOR ANALYSIS
LA English
DT Article
DE autism; behavioral variability; lag reinforcement; stereotypy; response
variability; stimulus variability
ID REPETITIVE BEHAVIOR; SCHEDULES
AB Repetitive and invariant behavior is a diagnostic feature of autism. We implemented a lag reinforcement schedule to increase response diversity for 6 participants with autism aged 6 to 10 years, 4 of whom also received prompting plus additional training. These procedures appeared to increase the variety of building-block structures, demonstrating that an intervention that includes differential reinforcement can increase response diversity for children with an autism spectrum disorder.
C1 [Napolitano, Deborah A.] Univ Rochester, Sch Med, Div Neurodev & Behav Pediat, Rochester, NY 14642 USA.
RP Napolitano, DA (reprint author), Univ Rochester, Sch Med, Div Neurodev & Behav Pediat, 601 Elmwood Ave,Box 671, Rochester, NY 14642 USA.
EM deborah_napolitano@urmc.rochester.edu
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NR 12
TC 13
Z9 13
PU JOURNAL APPL BEHAV ANAL
PI LAWRENCE
PA DEPT HUMAN DEVELOPMENT, UNIV KANSAS, LAWRENCE, KS 66045 USA
SN 0021-8855
J9 J APPL BEHAV ANAL
JI J. Appl. Behav. Anal.
PD SUM
PY 2010
VL 43
IS 2
BP 265
EP 271
DI 10.1901/jaba.2010.43-265
PG 7
WC Psychology, Clinical
SC Psychology
GA 610YI
UT WOS:000278776300006
PM 21119899
ER
PT J
AU Geiger, KB
LeBlanc, LA
Dillon, CM
Bates, SL
AF Geiger, Kaneen B.
LeBlanc, Linda A.
Dillon, Courtney M.
Bates, Stephanie L.
TI AN EVALUATION OF PREFERENCE FOR VIDEO AND IN VIVO MODELING
SO JOURNAL OF APPLIED BEHAVIOR ANALYSIS
LA English
DT Article
DE autism; concurrent-chains schedules; modeling; preference assessment;
video modeling
ID AUTISM; CHILDREN; INTERVENTIONS; SPECTRUM
AB We assessed preference for video or in vivo modeling using a concurrent-chains arrangement with 3 children with autism. The two modeling conditions produced similar acquisition rates and no differential selection (i.e., preference) for all 3 participants.
C1 [LeBlanc, Linda A.] Auburn Univ, Dept Psychol, Auburn, AL 36849 USA.
[Dillon, Courtney M.; Bates, Stephanie L.] Western Michigan Univ, Kalamazoo, MI 49008 USA.
RP LeBlanc, LA (reprint author), Auburn Univ, Dept Psychol, 226 Thach Hall, Auburn, AL 36849 USA.
EM leblanc@auburn.edu
CR Bellini S, 2007, EXCEPT CHILDREN, V73, P264
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Corbett B. A., 2005, J EARLY INTENSIVE BE, V2, P2
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Gilliam JE, 2006, GILLIAM AUTISM RATIN
Hanley GP, 2005, J APPL BEHAV ANAL, V38, P51, DOI 10.1901/jaba.2005.6-04
LeBlanc LA, 2003, J APPL BEHAV ANAL, V36, P253, DOI 10.1901/jaba.2003.36-253
Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
Marcus A, 2009, J APPL BEHAV ANAL, V42, P335, DOI 10.1901/jaba.2009.42-335
Sundberg M. L., 2008, VERBAL BEHAV MILESTO
NR 11
TC 4
Z9 4
PU JOURNAL APPL BEHAV ANAL
PI LAWRENCE
PA DEPT HUMAN DEVELOPMENT, UNIV KANSAS, LAWRENCE, KS 66045 USA
SN 0021-8855
J9 J APPL BEHAV ANAL
JI J. Appl. Behav. Anal.
PD SUM
PY 2010
VL 43
IS 2
BP 279
EP 283
DI 10.1901/jaba.2010.43-279
PG 5
WC Psychology, Clinical
SC Psychology
GA 610YI
UT WOS:000278776300008
PM 21119901
ER
PT J
AU Plavnick, JB
Ferreri, SJ
Maupin, AN
AF Plavnick, Joshua B.
Ferreri, Summer J.
Maupin, Angela N.
TI THE EFFECTS OF SELF-MONITORING ON THE PROCEDURAL INTEGRITY OF A
BEHAVIORAL INTERVENTION FOR YOUNG CHILDREN WITH DEVELOPMENTAL
DISABILITIES
SO JOURNAL OF APPLIED BEHAVIOR ANALYSIS
LA English
DT Article
DE autism; developmental disabilities; early childhood special education;
procedural integrity; self-monitoring; token economy
ID STUDENT BEHAVIOR; PERFORMANCE; FEEDBACK; TEACHERS
AB The effects of self-monitoring on the procedural integrity of token economy implementation by 3 staff in a special education classroom were evaluated. The subsequent changes in academic readiness behaviors of 2 students with low-incidence disabilities were measured. Multiple baselines across staff and students showed that procedural integrity increased when staff used monitoring checklists, and students' academic readiness behavior also increased. Results are discussed with respect to the use of self-monitoring and the importance of procedural integrity in public school settings.
C1 [Ferreri, Summer J.] Michigan State Univ, Coll Educ, E Lansing, MI 48824 USA.
RP Ferreri, SJ (reprint author), Michigan State Univ, Coll Educ, 340 Erickson, E Lansing, MI 48824 USA.
EM sferreri@msu.edu
CR Allen SJ, 2003, SCHOOL PSYCHOL QUART, V18, P22, DOI 10.1521/scpq.18.1.22.20878
DiGennaro FD, 2005, SCHOOL PSYCHOL REV, V34, P220
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Kazdin A. E., 1982, SINGLE CASE RES DESI
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SELIGSONPETSCHE.E, 2006, J APPL BEHAV ANAL, V39, P215
NR 8
TC 7
Z9 7
PU JOURNAL APPL BEHAV ANAL
PI LAWRENCE
PA DEPT HUMAN DEVELOPMENT, UNIV KANSAS, LAWRENCE, KS 66045 USA
SN 0021-8855
J9 J APPL BEHAV ANAL
JI J. Appl. Behav. Anal.
PD SUM
PY 2010
VL 43
IS 2
BP 315
EP 320
DI 10.1901/jaba.2010.43-315
PG 6
WC Psychology, Clinical
SC Psychology
GA 610YI
UT WOS:000278776300014
PM 21119907
ER
PT J
AU Vladescu, JC
Kodak, T
AF Vladescu, Jason C.
Kodak, Tiffany
TI A REVIEW OF RECENT STUDIES ON DIFFERENTIAL REINFORCEMENT DURING SKILL
ACQUISITION IN EARLY INTERVENTION
SO JOURNAL OF APPLIED BEHAVIOR ANALYSIS
LA English
DT Review
DE acquisition; differential reinforcement; early intervention;
reinforcement quality; reinforcement schedules
ID AUTISM; CHILDREN
AB Although the use of differential reinforcement has been recommended in previous investigations and in early intervention curriculum manuals, few studies have evaluated the best method for providing differential reinforcement to maximize independent responding. This paper reviews previous research on the effectiveness of differential reinforcement as treatment and describes important areas of future research.
C1 [Kodak, Tiffany] Univ Nebraska Med Ctr, Munroe Meyer Inst, Ctr Autism Spectrum Disorders, Omaha, NE 68198 USA.
RP Kodak, T (reprint author), Univ Nebraska Med Ctr, Munroe Meyer Inst, Ctr Autism Spectrum Disorders, 985450 Nebraska Med Ctr, Omaha, NE 68198 USA.
EM tkodak@unmc.edu
CR Clark KM, 2004, J APPL BEHAV ANAL, V37, P503, DOI 10.1901/jaba.2004.37-503
Fisher WW, 2007, J APPL BEHAV ANAL, V40, P489, DOI 10.1901/jaba.2007.40-489
HAUSMAN NL, J APPL BEHA IN PRESS
Karsten AM, 2009, J APPL BEHAV ANAL, V42, P327, DOI 10.1901/jaba.2009.42-327
Leaf R., 1999, WORK PROGR BEHAV MAN
Lovaas O. I., 2003, TEACHING INDIVIDUALS
Love JR, 2009, RES AUTISM SPECT DIS, V3, P421, DOI 10.1016/j.rasd.2008.08.008
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TOUCHETTE PE, 1984, J APPL BEHAV ANAL, V17, P175, DOI 10.1901/jaba.1984.17-175
Walker G, 2008, J AUTISM DEV DISORD, V38, P261, DOI 10.1007/s10803-007-0390-4
NR 10
TC 2
Z9 2
PU JOURNAL APPL BEHAV ANAL
PI LAWRENCE
PA DEPT HUMAN DEVELOPMENT, UNIV KANSAS, LAWRENCE, KS 66045 USA
SN 0021-8855
J9 J APPL BEHAV ANAL
JI J. Appl. Behav. Anal.
PD SUM
PY 2010
VL 43
IS 2
BP 351
EP 355
DI 10.1901/jaba.2010.43-351
PG 5
WC Psychology, Clinical
SC Psychology
GA 610YI
UT WOS:000278776300020
PM 21119913
ER
PT J
AU Hobson, RP
Lee, A
Hobson, JA
AF Hobson, R. Peter
Lee, Anthony
Hobson, Jessica A.
TI Personal Pronouns and Communicative Engagement in Autism
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism; Personal pronouns; Deixis; Eye gaze; Social interaction
ID JOINT ATTENTION; CHILDREN; IDENTIFICATION; LANGUAGE; ACQUISITION;
IMITATION; ENGLISH; SELF; ME
AB In three experimental conditions, we tested matched children with and without autism (n = 15 per group) for their comprehension and use of first person plural ('we') and third person singular ('he') pronouns, and examined whether such linguistic functioning related to their social interaction. The groups were indistinguishable in their comprehension and use of 'we' pronouns, although within each group, such usage was correlated with ratings of interpersonal connectedness with the collaborator. On the other hand, participants with autism were less likely to use third person pronouns or to show patterns of eye gaze reflecting engagement with an interlocutor's stance vis-A -vis a third person. In these settings, atypical third person pronoun usage seemed to reflect limited communicative engagement, but first person pronouns were relatively spared.
C1 [Hobson, R. Peter; Lee, Anthony; Hobson, Jessica A.] Tavistock Clin, London NW3 5BA, England.
[Hobson, R. Peter; Hobson, Jessica A.] UCL, Inst Child Hlth, London, England.
RP Hobson, RP (reprint author), Tavistock Clin, 120 Belsize Lane, London NW3 5BA, England.
EM r.hobson@ucl.ac.uk
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NR 42
TC 7
Z9 7
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD JUN
PY 2010
VL 40
IS 6
BP 653
EP 664
DI 10.1007/s10803-009-0910-5
PG 12
WC Psychology, Developmental
SC Psychology
GA 592IL
UT WOS:000277372000001
PM 20013041
ER
PT J
AU Adamson, LB
Deckner, DF
Bakeman, R
AF Adamson, Lauren B.
Deckner, Deborah F.
Bakeman, Roger
TI Early Interests and Joint Engagement in Typical Development, Autism, and
Down Syndrome
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Interests; Parent-child interaction; Autism; Down syndrome; Joint
attention; Communication development
ID YOUNG-CHILDREN; SPECTRUM DISORDER; ATTENTION; INFANTS; PLAY; RESPONSES;
LANGUAGE; BEHAVIOR; STIMULI; PEOPLE
AB This study examines how spontaneous interests in people and in objects relate to joint engagement in typically developing toddlers and young children with autism or Down syndrome. Ratings of interests were made repeatedly during intermissions in a laboratory-based protocol focused on caregiver-child interactions. Interests were moderated by diagnosis and relatively stable across intermissions. In autism, interest in people tended to be low and to decline rapidly, and the balance of interests favored familiar objects over people. Lower interest in people and in unfamiliar objects was associated with less coordinated joint engagement and with less steep developmental trajectories for symbol-infused joint engagement. These findings suggest that variations in interests may contribute to differences in the child's engagement during social interactions that facilitate the acquisition of language.
C1 [Adamson, Lauren B.; Deckner, Deborah F.; Bakeman, Roger] Georgia State Univ, Dept Psychol, Atlanta, GA 30303 USA.
RP Adamson, LB (reprint author), Georgia State Univ, Dept Psychol, Univ Plaza, Atlanta, GA 30303 USA.
EM ladamson@gsu.edu
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NR 58
TC 15
Z9 16
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD JUN
PY 2010
VL 40
IS 6
BP 665
EP 676
DI 10.1007/s10803-009-0914-1
PG 12
WC Psychology, Developmental
SC Psychology
GA 592IL
UT WOS:000277372000002
PM 20012678
ER
PT J
AU Wong, VCN
Kwan, QK
AF Wong, Virginia C. N.
Kwan, Queenie K.
TI Randomized Controlled Trial for Early Intervention for Autism: A Pilot
Study of the Autism 1-2-3 Project
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism; Autism spectrum disorder (ASD); Early intervention; Social
interaction; Communication; Autism diagnostic observation schedule
(ADOS)
ID SPECTRUM DISORDERS; YOUNG-CHILDREN; SYMBOLIC PLAY; STRESS;
COMMUNICATION; PARENTS; SETTINGS; SERVICES; SKILLS; AGE
AB We piloted a 2-week "Autism-1-2-3" early intervention for children with autism and their parents immediately after diagnosis that targeted at (1) eye contact, (2) gesture and (3) vocalization/words. Seventeen children were randomized into the Intervention (n = 9) and Control (n = 8) groups. Outcome measures included the Autism Diagnostic Observation Schedule, Ritvo-Freeman Real Life Rating Scale, Symbolic Play Test, and Parenting Stress Index. Children with autism improved in language/communication, reciprocal social interaction, and symbolic play. Parents perceived significant improvement in their children's language, social interaction, and their own stress level. This intervention can serve as short-term training on communication and social interaction for children with autism, and reduce the stress of their parents during the long waiting time for public health services.
C1 [Wong, Virginia C. N.; Kwan, Queenie K.] Univ Hong Kong, Div Child Neurol Dev Paediat Neurohabilitat, Dept Paediat & Adolescent Med, Hong Kong, Peoples R China.
RP Wong, VCN (reprint author), Univ Hong Kong, Div Child Neurol Dev Paediat Neurohabilitat, Dept Paediat & Adolescent Med, Pokfulam Rd, Hong Kong, Peoples R China.
EM vcnwong@hku.hk
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NR 46
TC 17
Z9 17
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD JUN
PY 2010
VL 40
IS 6
BP 677
EP 688
DI 10.1007/s10803-009-0916-z
PG 12
WC Psychology, Developmental
SC Psychology
GA 592IL
UT WOS:000277372000003
PM 20020319
ER
PT J
AU Oosterling, I
Roos, S
de Bildt, A
Rommelse, N
de Jonge, M
Visser, J
Lappenschaar, M
Swinkels, S
van der Gaag, RJ
Buitelaar, J
AF Oosterling, Iris
Roos, Sascha
de Bildt, Annelies
Rommelse, Nanda
de Jonge, Maretha
Visser, Janne
Lappenschaar, Martijn
Swinkels, Sophie
van der Gaag, Rutger Jan
Buitelaar, Jan
TI Improved Diagnostic Validity of the ADOS Revised Algorithms: A
Replication Study in an Independent Sample
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism; ADOS; Algorithm; Sensitivity; Specificity; Diagnosis
ID AUTISM SPECTRUM DISORDERS; PERVASIVE DEVELOPMENTAL DISORDERS;
OBSERVATION-SCHEDULE; CHILDREN; ADOLESCENTS; INTERVIEW; CRITERIA
AB Recently, Gotham et al. (2007) proposed revised algorithms for the Autism Diagnostic Observation Schedule (ADOS) with improved diagnostic validity. The aim of the current study was to replicate predictive validity, factor structure, and correlations with age and verbal and nonverbal IQ of the ADOS revised algorithms for Modules 1 and 2 in a large independent Dutch sample (N = 532). Results showed that the improvement of diagnostic validity was most apparent for autism, except in very young or low functioning children. Results for other autism spectrum disorders were less consistent. Overall, these findings support the use of the more homogeneous revised algorithms, with the use of similar items across developmental cells making it easier to compare ADOS scores within and between individuals.
C1 [Oosterling, Iris; Roos, Sascha; Rommelse, Nanda; Visser, Janne; Swinkels, Sophie; van der Gaag, Rutger Jan; Buitelaar, Jan] Karakter Child & Adolescent Psychiat Univ Ctr, NL-6525 GC Nijmegen, Netherlands.
[Rommelse, Nanda; Lappenschaar, Martijn; Swinkels, Sophie; van der Gaag, Rutger Jan; Buitelaar, Jan] Radboud Univ Nijmegen Med Ctr, Dept Psychiat, Nijmegen, Netherlands.
[de Bildt, Annelies] Univ Groningen, Univ Med Ctr Groningen, Child & Adolescent Psychiat Unit, NL-9713 AV Groningen, Netherlands.
[de Jonge, Maretha] Univ Med Ctr Utrecht, Rudolf Magnus Inst Neurosci, Dept Child & Adolescent Psychiat, Utrecht, Netherlands.
[Rommelse, Nanda; Swinkels, Sophie; van der Gaag, Rutger Jan; Buitelaar, Jan] NCEBP, Nijmegen, Netherlands.
RP Oosterling, I (reprint author), Karakter Child & Adolescent Psychiat Univ Ctr, Reinier Postlaan 12, NL-6525 GC Nijmegen, Netherlands.
EM i.oosterling@karakter.com
RI Buitelaar, Jan/E-4584-2012; Rommelse, Nanda/D-4872-2009; Gaag,
R.J./H-8030-2014
OI Buitelaar, Jan/0000-0001-8288-7757; Rommelse, Nanda/0000-0002-1711-0359;
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
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NR 32
TC 18
Z9 18
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD JUN
PY 2010
VL 40
IS 6
BP 689
EP 703
DI 10.1007/s10803-009-0915-0
PG 15
WC Psychology, Developmental
SC Psychology
GA 592IL
UT WOS:000277372000004
PM 20148299
ER
PT J
AU Dias, GG
Prado, EFGB
Vadasz, E
Siqueira, JTT
AF Dias, Guilherme G.
Prado, Eliane F. G. B.
Vadasz, Estevao
Siqueira, Jose Tadeu T.
TI Evaluation of the Efficacy of a Dental Plaque Control Program in
Autistic Patients
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism; OHI-S; Oral hygiene; Oral health; Dental plaque
AB The aim of this study was to verify the efficacy of a programme for dental plaque control in autistics. Patients were evaluated on five occasions over a period of 180 days using the following instruments: OHI-S, DMF-T, the Fonnes brushing technique and diet questionnaire. Participants were divided into two groups according to level of co-operation on the programme: Group A (co-operative) and Group B (non-cooperative). A statistically significant improvement (p < 0.001) in Oral Hygiene was attained, with 84.2% showing regular or satisfactory hygiene at study end-point. Conclusion: Groups A and B both showed improvement in hygiene (p < 0.001 and p = 0.004), but improvement was significantly higher among co-operative patients (p < 0.001 at 180 days), who also had a higher mean age (p = 0.02).
C1 [Dias, Guilherme G.; Prado, Eliane F. G. B.; Vadasz, Estevao] Univ Sao Paulo, Fac Med, Dept Psychiat, Sao Paulo, Brazil.
[Dias, Guilherme G.; Prado, Eliane F. G. B.; Vadasz, Estevao] Univ Sao Paulo, Fac Med, Inst Psychiat, Sao Paulo, Brazil.
[Siqueira, Jose Tadeu T.] Univ Sao Paulo, Fac Med, Hosp Clin, Dent Div, Sao Paulo, Brazil.
RP Siqueira, JTT (reprint author), Rua Maria Candida 135,Vila Guilherme, BR-02071010 Sao Paulo, Brazil.
EM guilhermegdias@yahoo.com.br; jtts@uol.com.br
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NR 22
TC 2
Z9 2
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD JUN
PY 2010
VL 40
IS 6
BP 704
EP 708
DI 10.1007/s10803-009-0918-x
PG 5
WC Psychology, Developmental
SC Psychology
GA 592IL
UT WOS:000277372000005
PM 20052608
ER
PT J
AU Reichle, J
Johnson, L
Monn, E
Harris, M
AF Reichle, Joe
Johnson, LeAnne
Monn, Emily
Harris, Michael
TI Task Engagement and Escape Maintained Challenging Behavior: Differential
Effects of General and Explicit Cues When Implementing a Signaled Delay
in the Delivery of Reinforcement
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism; Tolerance for delay; Signaled delay; Intervention;
Self-regulation
ID NEGATIVE REINFORCEMENT; DISRUPTIVE BEHAVIOR; EXTINCTION; CHILDREN;
AUTISM; INTERVENTION; TOPOGRAPHIES; MANAGEMENT; REDUCTION; TOLERANCE
AB This study was designed to evaluate the effects of explicit and general delay cues when implementing a tolerance for a delay in the delivery of a reinforcement procedure to increase task engagement and decrease escape maintained challenging behavior. Two preschool children with autism participated in an alternating treatments design with changing criterions for task engagement. For both children, descriptive and experimental analyses verified that the challenging behavior functioned to escape instructional task demands. Subsequently, two types of tasks were identified for each participant with assignment to either the explicit or general cue procedures. Both participants demonstrated increased task engagement with concurrent decreases in challenging behavior with both types of delay cues, though rate of successful work unit completion advanced more quickly with explicit delay cues.
C1 [Reichle, Joe] Univ Minnesota, Dept Educ Psychol, Dept Speech Language Hearing Sci, Minneapolis, MN 55455 USA.
[Harris, Michael] Univ Wisconsin, River Falls, WI 54022 USA.
RP Reichle, J (reprint author), Univ Minnesota, Dept Educ Psychol, Dept Speech Language Hearing Sci, 250 Educ Sci Bldg,56 E River Rd, Minneapolis, MN 55455 USA.
EM reich001@umn.edu
CR ALLEN KD, 1992, J APPL BEHAV ANAL, V25, P629, DOI 10.1901/jaba.1992.25-629
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NR 38
TC 3
Z9 3
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD JUN
PY 2010
VL 40
IS 6
BP 709
EP 720
DI 10.1007/s10803-010-0946-6
PG 12
WC Psychology, Developmental
SC Psychology
GA 592IL
UT WOS:000277372000006
PM 20162345
ER
PT J
AU Kuhlthau, K
Orlich, F
Hall, TA
Sikora, D
Kovacs, EA
Delahaye, J
Clemons, TE
AF Kuhlthau, Karen
Orlich, Felice
Hall, Trevor A.
Sikora, Darryn
Kovacs, Erica A.
Delahaye, Jennifer
Clemons, Traci E.
TI Health-Related Quality of Life in Children with Autism Spectrum
Disorders: Results from the Autism Treatment Network
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism; Quality of life; Behavior; Adaptive behavior
ID HIGH-FUNCTIONING CHILDREN; ATTENTION-DEFICIT/HYPERACTIVITY DISORDER;
GENERIC CORE SCALES; INTELLECTUAL DISABILITY; PSYCHOMETRIC PROPERTIES;
MATERNAL PERCEPTIONS; SLEEP PROBLEMS; ADOLESCENTS; POPULATION;
PEDSQL(TM)-4.0
AB We examined data collected as a part of the Autism Treatment Network, a group of 15 autism centers across the United States and Canada. Mean Health-Related Quality of Life (HRQoL) scores of the 286 children assessed were significantly lower than those of healthy populations (according to published norms). When compared to normative data from children with chronic conditions, children with ASD demonstrated worse HRQoL for total, psychosocial, emotional and social functioning, but did not demonstrate differing scores for physical and school functioning. HRQoL was not consistently related to ASD diagnosis or intellectual ability. However, it was consistently related to internalizing and externalizing problems as well as repetitive behaviors, social responsiveness, and adaptive behaviors. Associations among HRQoL and behavioral characteristics suggest that treatments aimed at improvements in these behaviors may improve HRQoL.
C1 [Kuhlthau, Karen; Delahaye, Jennifer] Massachusetts Gen Hosp, Ctr Child & Adolescent Hlth Policy, Boston, MA 02114 USA.
[Kuhlthau, Karen] Harvard Univ, Sch Med, Dept Pediat, Boston, MA 02114 USA.
[Orlich, Felice] Univ Washington, Dept Psychiat & Behav Sci, Seattle, WA 98195 USA.
[Orlich, Felice] Seattle Childrens Hosp, Autism Program, Seattle, WA USA.
[Hall, Trevor A.] Warm Springs Autism Diagnost & Treatment Ctr, Portland, OR USA.
[Hall, Trevor A.; Sikora, Darryn] Oregon Hlth & Sci Univ, Portland, OR 97201 USA.
[Kovacs, Erica A.] Columbia Univ, Med Ctr, Columbia Dev Neuropsychiat Program, Div Child & Adolescent Psychiat, New York, NY USA.
[Clemons, Traci E.] EMMES Corp, Potomac, MD USA.
RP Kuhlthau, K (reprint author), Massachusetts Gen Hosp, Ctr Child & Adolescent Hlth Policy, Boston, MA 02114 USA.
EM kkuhlthau@partners.org
CR Achenbach T. M., 2000, MANUAL ASEBA SCH AGE
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NR 42
TC 37
Z9 38
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD JUN
PY 2010
VL 40
IS 6
BP 721
EP 729
DI 10.1007/s10803-009-0921-2
PG 9
WC Psychology, Developmental
SC Psychology
GA 592IL
UT WOS:000277372000007
PM 20033762
ER
PT J
AU Loth, E
Happe, F
Gomez, JC
AF Loth, Eva
Happe, Francesca
Gomez, Juan Carlos
TI Variety is Not the Spice of Life for People with Autism Spectrum
Disorders: Frequency Ratings of Central, Variable and Inappropriate
Aspects of Common Real-life Events
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism spectrum disorders; Theory of mind; Weak central coherence; Event
schemas; Repetitive behaviours
ID HIGH-FUNCTIONING AUTISM; WEAK CENTRAL COHERENCE; ASPERGER-SYNDROME;
DOWN-SYNDROME; CHILDREN; MIND; INDIVIDUALS; PERFORMANCE; IMITATION; TASK
AB This study used a novel rating task to investigate whether high-functioning individuals with autism spectrum disorder (ASD) have difficulties distinguishing essential from variable aspects of familiar events. Participants read stories about everyday events and judged how often central, variable, and inappropriate event-components normally occur in this type of situation. The ASD boys made significantly more errors than the typically developing boys in rating the occurrences of variable aspects. In both groups, ratings of variable aspects were age-related, but in the ASD boys, they were also related to theory of mind and weak coherence test scores, and to severity of autistic symptoms. Implications for the understanding of some repetitive behaviours, such as the tendency to adhere to inflexible routines, are discussed.
C1 [Loth, Eva; Happe, Francesca] Kings Coll London, Inst Psychiat, MRC Social Genet & Dev Psychiat Ctr, London SE5 8AF, England.
[Gomez, Juan Carlos] Univ St Andrews, Sch Psychol, St Andrews, Fife, Scotland.
RP Loth, E (reprint author), Kings Coll London, Inst Psychiat, MRC Social Genet & Dev Psychiat Ctr, Crespigny Pk, London SE5 8AF, England.
EM eva.loth@kcl.ac.uk
RI Happe, Francesca/D-5544-2012
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NR 42
TC 5
Z9 5
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD JUN
PY 2010
VL 40
IS 6
BP 730
EP 742
DI 10.1007/s10803-009-0929-7
PG 13
WC Psychology, Developmental
SC Psychology
GA 592IL
UT WOS:000277372000008
PM 20066484
ER
PT J
AU Fatemi, SH
Reutiman, TJ
Folsom, TD
Rooney, RJ
Patel, DH
Thuras, PD
AF Fatemi, S. Hossein
Reutiman, Teri J.
Folsom, Timothy D.
Rooney, Robert J.
Patel, Diven H.
Thuras, Paul D.
TI mRNA and Protein Levels for GABA(A)alpha 4, alpha 5, beta 1 and
GABA(B)R1 Receptors are Altered in Brains from Subjects with Autism
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE GABBR1; GABR alpha 4; GABR alpha 5; GABR beta 1; Autism; Brain
ID ACID DECARBOXYLASE 65; SUBUNIT GENES; NEURODEVELOPMENTAL DISORDERS;
SIGNIFICANT ASSOCIATION; SPECTRUM DISORDERS; GABBR1 GENE; 67 KDA;
EXPRESSION; SCHIZOPHRENIA; MOUSE
AB We have shown altered expression of gamma-aminobutyric acid A (GABA(A)) and gamma-aminobutyric acid B (GABA(B)) receptors in the brains of subjects with autism. In the current study, we sought to verify our western blotting data for GABBR1 via qRT-PCR and to expand our previous work to measure mRNA and protein levels of 3 GABA(A) subunits previously associated with autism (GABR alpha 4; GABR alpha 5; GABR beta 1). Three GABA receptor subunits demonstrated mRNA and protein level concordance in superior frontal cortex (GABR alpha 4, GABR alpha 5, GABR beta 1) and one demonstrated concordance in cerebellum (GABI'R1). These results provide further evidence of impairment of GABAergic signaling in autism.
C1 [Fatemi, S. Hossein; Reutiman, Teri J.; Folsom, Timothy D.; Thuras, Paul D.] Univ Minnesota, Dept Psychiat, Sch Med, Div Neurosci Res, Minneapolis, MN 55455 USA.
[Fatemi, S. Hossein] Univ Minnesota, Dept Pharmacol, Sch Med, Minneapolis, MN 55455 USA.
[Fatemi, S. Hossein] Univ Minnesota, Dept Neurosci, Sch Med, Minneapolis, MN 55455 USA.
[Rooney, Robert J.; Patel, Diven H.] Genome Explorat Inc, Memphis, TN USA.
[Thuras, Paul D.] VA Med Ctr, Minneapolis, MN USA.
RP Fatemi, SH (reprint author), Univ Minnesota, Dept Psychiat, Sch Med, Div Neurosci Res, 420 Delaware St SE MMC 392, Minneapolis, MN 55455 USA.
EM fatem002@umn.edu
CR American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th
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NR 36
TC 58
Z9 58
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD JUN
PY 2010
VL 40
IS 6
BP 743
EP 750
DI 10.1007/s10803-009-0924-z
PG 8
WC Psychology, Developmental
SC Psychology
GA 592IL
UT WOS:000277372000009
PM 20066485
ER
PT J
AU Bauminger, N
Solomon, M
Rogers, SJ
AF Bauminger, Nirit
Solomon, Marjorie
Rogers, Sally J.
TI Predicting Friendship Quality in Autism Spectrum Disorders and Typical
Development
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE HFASD; Asperger syndrome; Friendship; Attachment; Theory of mind
ID INDIVIDUAL-DIFFERENCES; ATTACHMENT; CHILDREN; SECURITY; ADOLESCENCE;
BEHAVIOR; SCALE
AB The role played by social relationship variables (attachment security; mother-child relationship qualities) and social-cognitive capacities (theory of mind) was examined in both observed friendship behaviors and in children's descriptions of friendships (age 8-12) with high functioning children with autism spectrum disorders (HFASD) (n = 44) and with typical development (TYP) (n = 38). Overall, half of the HFASD sample (54.45%) reported maternal attachment security, corroborating data from younger children with ASD. The hypothesized predictors and their interrelations had both direct and indirect effects on friendship for both groups of children, highlighting the importance of these factors in children's friendship development and suggesting both compensatory and amplification mechanisms for friendship qualities. Practical and clinical implications are discussed for friendship support in both ASD and TYP.
C1 [Bauminger, Nirit] Bar Ilan Univ, Sch Educ, IL-52900 Ramat Gan, Israel.
[Solomon, Marjorie; Rogers, Sally J.] UC Davis, Mind Inst, Dept Psychiat, Sacramento, CA USA.
RP Bauminger, N (reprint author), Bar Ilan Univ, Sch Educ, IL-52900 Ramat Gan, Israel.
EM bauminn@mail.biu.ac.il
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NR 35
TC 11
Z9 11
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD JUN
PY 2010
VL 40
IS 6
BP 751
EP 761
DI 10.1007/s10803-009-0928-8
PG 11
WC Psychology, Developmental
SC Psychology
GA 592IL
UT WOS:000277372000010
PM 20039110
ER
PT J
AU Drake, JE
Redash, A
Coleman, K
Haimson, J
Winner, E
AF Drake, Jennifer E.
Redash, Amanda
Coleman, Katelyn
Haimson, Jennifer
Winner, Ellen
TI 'Autistic' Local Processing Bias also Found in Children Gifted in
Realistic Drawing
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism; Perceptual cohesiveness; Giftedness; Drawing
ID HIGH-FUNCTIONING AUTISM; BLOCK DESIGN; TRAITS; SPECTRUM; INDIVIDUALS;
PERFORMANCE; POPULATION; PERCEPTION; ABILITIES; ATTENTION
AB We investigated whether typically-developing children with a gift for drawing realistically show the local processing bias seen in individuals with autism spectrum disorder (ASD). Twenty-seven 6-12 year-olds made an observational drawing (scored for level of realism) and completed three local processing tasks, and parents completed the Childhood Asperger Syndrome Test (CAST). Drawing score predicted local processing performance on all tasks independently of verbal IQ, age, and years of art lessons. Drawing score also predicted more frequent repetitive behaviors as assessed by the CAST. Thus, skill in realistic drawing is associated with a strong local processing bias and a tendency towards repetitive behaviors, showing that traits found in individuals with ASD irrespective of artistic talent are also found in typically developing children with artistic talent.
C1 [Drake, Jennifer E.; Redash, Amanda; Coleman, Katelyn; Haimson, Jennifer; Winner, Ellen] Boston Coll, Dept Psychol, Chestnut Hill, MA 02167 USA.
[Winner, Ellen] Harvard Univ, Grad Sch Educ, Project Zero, Cambridge, MA 02138 USA.
RP Drake, JE (reprint author), Boston Coll, Dept Psychol, Chestnut Hill, MA 02167 USA.
EM drakejc@bc.edu
CR American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th
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NR 40
TC 7
Z9 7
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD JUN
PY 2010
VL 40
IS 6
BP 762
EP 773
DI 10.1007/s10803-009-0923-0
PG 12
WC Psychology, Developmental
SC Psychology
GA 592IL
UT WOS:000277372000011
PM 20049633
ER
PT J
AU Hippler, K
Viding, E
Klicpera, C
Happe, F
AF Hippler, Kathrin
Viding, Essi
Klicpera, Christian
Happe, Francesca
TI Brief Report: No Increase in Criminal Convictions in Hans Asperger's
Original Cohort
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Asperger syndrome; Autistic psychopathy; Convictions; Offending
ID AUTISM SPECTRUM DISORDER; BEHAVIOR; PSYCHOPATHY; VIOLENCE
AB Hans Asperger originally used the term "autistic psychopathy" to describe his patients on the autism spectrum, leading to a possible confusion with psychopathic disorder and delinquent behaviour. We conducted a penal register search for 177 former patients of Asperger's clinic with a childhood diagnosis of "autistic psychopathy" or features of the disorder in Austria. The mean percentage of registered convictions was similar to that in the general male population of Austria over the studied time period. A qualitative assessment of offence types in Asperger's former patients suggests that the nature of offences does not differ from that in the general population. In this original cohort of Asperger's patients, convictions were no more common than in the general male population.
C1 [Hippler, Kathrin] Univ Klin Kinder & Jugendheilkunde, Tagesklin Stn Psychosomat, A-1090 Vienna, Austria.
[Hippler, Kathrin; Klicpera, Christian] Univ Vienna, Dept Clin & Appl Psychol, Vienna, Austria.
[Viding, Essi] UCL, Res Dept Clin Educ & Hlth Psychol, Div Psychol & Language Sci, London, England.
[Happe, Francesca] Kings Coll London, Inst Psychiat, MRC Social Genet & Dev Psychiat Ctr, London WC2R 2LS, England.
RP Hippler, K (reprint author), Med Univ Vienna, Dept Paediat & Adolescent Med, Vienna, Austria.
EM kathrin.hippler@meduniwien.ac.at
RI Happe, Francesca/D-5544-2012
CR Allen D, 2008, J AUTISM DEV DISORD, V38, P748, DOI 10.1007/s10803-007-0442-9
American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th
Asperger H, 1944, ARCH PSYCHIAT NERVEN, V117, P76, DOI 10.1007/BF01837709
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NR 29
TC 6
Z9 6
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD JUN
PY 2010
VL 40
IS 6
BP 774
EP 780
DI 10.1007/s10803-009-0917-y
PG 7
WC Psychology, Developmental
SC Psychology
GA 592IL
UT WOS:000277372000012
PM 20024608
ER
PT J
AU Brown, JT
AF Brown, Jane Thierfeld
TI Realizing the College Dream with Autism or Asperger Syndrome
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Book Review
C1 [Brown, Jane Thierfeld] Univ Connecticut, Sch Law, Coll Autism Spectrum LLC, Hartford, CT 06112 USA.
RP Brown, JT (reprint author), Univ Connecticut, Sch Law, Coll Autism Spectrum LLC, Hartford, CT 06112 USA.
EM jane.brown@law.uconn.edu
CR BROWN JT, 2006, ANN PALMER REALIZING
NR 1
TC 1
Z9 1
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD JUN
PY 2010
VL 40
IS 6
BP 782
EP 782
DI 10.1007/s10803-009-0846-9
PG 1
WC Psychology, Developmental
SC Psychology
GA 592IL
UT WOS:000277372000014
ER
PT J
AU Frazier, TW
Youngstrom, EA
Haycook, T
Sinoff, A
Dimitriou, F
Knapp, J
Sinclair, L
AF Frazier, Thomas W.
Youngstrom, Eric A.
Haycook, Travis
Sinoff, Aletta
Dimitriou, Francine
Knapp, Julie
Sinclair, Leslie
TI Effectiveness of Medication Combined with Intensive Behavioral
Intervention for Reducing Aggression in Youth with Autism Spectrum
Disorder
SO JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY
LA English
DT Article
ID PERVASIVE DEVELOPMENTAL DISORDERS; OBSESSIVE-COMPULSIVE DISORDER;
HIGH-FUNCTIONING AUTISM; BIPOLAR DISORDER; MENTAL-RETARDATION; CHILDREN;
ADOLESCENTS; RISPERIDONE; EFFICACY; THERAPY
AB Background: The use of antipsychotic medications to treat aggression in youths with autism spectrum disorders (ASD) is based on open-label trials and efficacy studies. There are no studies examining the combined effectiveness of antipsychotic medications and intensive behavioral intervention (IBI) to treat aggression in ASD.
Methods: Youths with ASD and aggressive behavior received IBI. Medication use remained stable during the study period and was coded into antipsychotic, mood-stabilizing, and nonstimulant attention-deficit/hyperactivity disorder (ADHD)/sleep medication classes. Analysis of covariance (ANCOVA) and survival analyses examined the effects of medication classes on the average number of aggressive behaviors and time to behavior plan success.
Results: Thirty-two youths (mean age = 11.16, standard deviation [SD] = 3.31, range =4-16 years, 75% male) with ASD received aggression reduction plans. Of these, 25 youths were taking at least one psychiatric medication (antipsychotic n = 18, mood stabilizing n = 10, and nonstimulant ADHD/sleep n = 12). Aggression dropped substantially following implementation of IBI (p< 0.001; d = 1.70). Antipsychotic medication use predicted significantly fewer sessions to achieve behavior plan success (x(2)(1) = 5.67, p = 0.017; d = 0.93). No other medication classes influenced aggressive behavior (largest x(2)(1) = 0.16, p = 0.694).
Conclusions: Behavioral treatment combined with antipsychotic medication was the most effective approach to reducing aggressive behaviors in youths with ASD. Mood-stabilizing and nonstimulant ADHD/sleep medications did not contribute to aggression reduction.
C1 [Frazier, Thomas W.; Haycook, Travis; Sinoff, Aletta; Dimitriou, Francine; Knapp, Julie; Sinclair, Leslie] Cleveland Clin, Ctr Autism, Cleveland, OH 44195 USA.
[Frazier, Thomas W.] Cleveland Clin, Ctr Pediat Behav Hlth, Cleveland, OH 44195 USA.
[Youngstrom, Eric A.] Univ N Carolina, Dept Psychol, Chapel Hill, NC USA.
[Youngstrom, Eric A.] Univ N Carolina, Dept Psychiat, Chapel Hill, NC USA.
RP Frazier, TW (reprint author), Cleveland Clin, Ctr Autism CR11, 9500 Euclid Ave, Cleveland, OH 44195 USA.
EM fraziet2@ccf.org
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NR 61
TC 16
Z9 16
PU MARY ANN LIEBERT INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1044-5463
J9 J CHILD ADOL PSYCHOP
JI J. Child Adolesc. Psychopharmacol.
PD JUN
PY 2010
VL 20
IS 3
BP 167
EP 177
DI 10.1089/cap.2009.0048
PG 11
WC Pediatrics; Pharmacology & Pharmacy; Psychiatry
SC Pediatrics; Pharmacology & Pharmacy; Psychiatry
GA 615WA
UT WOS:000279167600001
PM 20578929
ER
PT J
AU Russell, G
Ford, T
Steer, C
Golding, J
AF Russell, Ginny
Ford, Tamsin
Steer, Colin
Golding, Jean
TI Identification of children with the same level of impairment as children
on the autistic spectrum, and analysis of their service use
SO JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY
LA English
DT Article
DE Autism; pervasive developmental disorders; Asperger's syndrome;
epidemiology; prevalence; child mental health
ID PREVALENCE; DISORDERS; COHORT
AB Background:
Data from epidemiology have consistently highlighted a disparity between the true prevalence of childhood psychiatric disorders and their recognition as defined by receiving a clinical diagnosis. Few studies have looked specifically at the level of unidentified autistic spectrum disorder (ASD) in the population.
Method:
Logistic regression was used to determine the behavioural traits associated with receiving a diagnosis of ASD using data from the Avon Longitudinal Study of Parents and Children (ALSPAC). A composite score was derived to measure levels of autistic traits; undiagnosed children with scores matching those diagnosed with ASD were identified. Levels of educational provision beyond that provided by standard schooling were examined.
Results:
Fifty-five percent of children with autistic traits at the same levels as those who had an autism diagnosis had not been identified as needing extra support from education or specialised health services. Of those who were identified as having special needs, 37.5% had been formally diagnosed with an ASD. For children with impairment at the same level as that associated with Asperger's syndrome, 57% had no special provision at school, and were not accessing specialised health services. Twenty-six percent of those who did have special provision at school had an ASD diagnosis.
Conclusions:
The results suggest that there may be a substantial proportion of children on the autistic spectrum who are never identified by services.
C1 [Russell, Ginny] Univ Exeter, ESRC Ctr Genom Soc, Exeter EX4 4PJ, Devon, England.
[Ford, Tamsin] Peninsula Coll Med & Dent, Inst Hlth Serv Res, Exeter, Devon, England.
[Steer, Colin; Golding, Jean] Univ Bristol, Dept Community Based Med, Bristol BS8 1TH, Avon, England.
RP Russell, G (reprint author), Univ Exeter, ESRC Ctr Genom Soc, Byrne House,St Germans Rd, Exeter EX4 4PJ, Devon, England.
EM g.russell@ex.ac.uk
FU Medical Research Council; Economic and Social Research Council
FX We are extremely grateful to all the families who took part in this
study, the midwives for their help in recruiting them, and the whole
ALSPAC team, which includes interviewers, computer and laboratory
technicians, clerical workers, research scientists, volunteers,
managers, receptionists and nurses. The UK Medical Research Council, the
Wellcome Trust and the University of Bristol provide core support for
ALSPAC. The work of the first author was specifically funded by the
Medical Research Council and Economic and Social Research Council. We
would also like to thank Brahm Norwich for his helpful comments.
CR Bailey A, 1996, J CHILD PSYCHOL PSYC, V37, P89, DOI 10.1111/j.1469-7610.1996.tb01381.x
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NR 26
TC 7
Z9 7
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0021-9630
J9 J CHILD PSYCHOL PSYC
JI J. Child Psychol. Psychiatry
PD JUN
PY 2010
VL 51
IS 6
BP 643
EP 651
DI 10.1111/j.1469-7610.2010.02233.x
PG 9
WC Psychology, Developmental; Psychiatry; Psychology
SC Psychology; Psychiatry
GA 594HI
UT WOS:000277526700002
PM 20345841
ER
PT J
AU Tadic, V
Pring, L
Dale, N
AF Tadic, Valerie
Pring, Linda
Dale, Naomi
TI Are language and social communication intact in children with congenital
visual impairment at school age?
SO JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY
LA English
DT Article
DE Visual impairment; language; social communication; autism
ID BLIND-CHILDREN; YOUNG-CHILDREN; AUTISM; MIND; EMOTION; SETBACK
AB Background:
Development of children with congenital visual impairment (VI) has been associated with vulnerable socio-communicative outcomes often bearing striking similarities to those of sighted children with autism.1 To date, very little is known about language and social communication in children with VI of normal intelligence.
Methods:
We examined the presentation of language and social communication of 15 children with VI and normal-range verbal intelligence, age 6-12 years, using a standardised language assessment and parental reports of everyday social and communicative behaviours. Their profiles were compared to those of typically developing sighted children of similar age and verbal ability.
Results:
Compared to their sighted peers, and relative to their own good and potentially superior structural language skills, children with VI showed significantly poorer use of language for social purposes. Pragmatic language weaknesses were a part of a broader socio-communicative profile of difficulties, present in a substantial proportion of these children and consistent with the pattern found in sighted children with autism.
Conclusions:
There are ongoing socio-communicative and pragmatic language difficulties in children with congenital VI at school age, despite their good intellectual abilities and advanced linguistic skills. Further research is required to unpack the underlying causes and factors maintaining this vulnerability in such children.
C1 [Tadic, Valerie] UCL Inst Child Hlth, MRC Ctr Epidemiol Child Hlth, London WC1E 2EH, England.
[Tadic, Valerie; Pring, Linda] Univ London, London WC1E 7HU, England.
[Dale, Naomi] Great Ormond St Hosp NHS Trust, London, England.
RP Tadic, V (reprint author), UCL Inst Child Hlth, MRC Ctr Epidemiol Child Hlth, 30 Guildford St, London WC1E 2EH, England.
EM v.tadic@ich.ucl.ac.uk
FU ESRC [PTA-031-2004-00211]
FX The authors thank the children and their families who participated in
this research. The research was supported by a 1 + 3 ESRC studentship
(PTA-031-2004-00211) awarded to the first author while completing a PhD
at Goldsmiths, University of London.
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NR 40
TC 7
Z9 7
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0021-9630
J9 J CHILD PSYCHOL PSYC
JI J. Child Psychol. Psychiatry
PD JUN
PY 2010
VL 51
IS 6
BP 696
EP 705
DI 10.1111/j.1469-7610.2009.02200.x
PG 10
WC Psychology, Developmental; Psychiatry; Psychology
SC Psychology; Psychiatry
GA 594HI
UT WOS:000277526700008
PM 20025621
ER
PT J
AU Grinter, EJ
Maybery, MT
Pellicano, E
Badcock, JC
Badcock, DR
AF Grinter, Emma J.
Maybery, Murray T.
Pellicano, Elizabeth
Badcock, Johanna C.
Badcock, David R.
TI Perception of shapes targeting local and global processes in autism
spectrum disorders
SO JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY
LA English
DT Article
DE Autism; local processing; global processing; ventral visual pathway;
radial frequency patterns
ID DEVELOPMENTAL DISORDERS; VISUAL-PERCEPTION; COGNITIVE-STYLE; WEAK
COHERENCE; FORM VISION; MOTION; CHILDREN; INFORMATION; CONTOURS;
RECOGNITION
AB Background:
Several researchers have found evidence for impaired global processing in the dorsal visual stream in individuals with autism spectrum disorders (ASDs). However, support for a similar pattern of visual processing in the ventral visual stream is less consistent. Critical to resolving the inconsistency is the assessment of local and global form processing ability.
Methods:
Within the visual domain, radial frequency (RF) patterns - shapes formed by sinusoidally varying the radius of a circle to add 'bumps' of a certain number to a circle - can be used to examine local and global form perception. Typically developing children and children with an ASD discriminated between circles and RF patterns that are processed either locally (RF24) or globally (RF3).
Results:
Children with an ASD required greater shape deformation to identify RF3 shapes compared to typically developing children, consistent with difficulty in global processing in the ventral stream. No group difference was observed for RF24 shapes, suggesting intact local ventral-stream processing.
Conclusions:
These outcomes support the position that a deficit in global visual processing is present in ASDs, consistent with the notion of Weak Central Coherence.
C1 [Grinter, Emma J.; Maybery, Murray T.; Pellicano, Elizabeth; Badcock, David R.] Univ Western Australia, Sch Psychol, Perth, WA 6009, Australia.
[Badcock, Johanna C.] Univ Western Australia, Sch Psychiat & Clin Neurosci, Graylands Hosp, Ctr Clin Res Neuropsychiat, Perth, WA 6009, Australia.
[Pellicano, Elizabeth] Univ Bristol, Dept Expt Psychol, Bristol BS8 1TH, Avon, England.
RP Grinter, EJ (reprint author), Univ Western Australia, Sch Psychol, 35 Stirling Highway, Perth, WA 6009, Australia.
EM emmagrinter@graduate.uwa.edu.au
RI Badcock, David/A-4913-2008; Badcock, Johanna/C-3682-2013; Maybery,
Murray/H-5390-2014
OI Badcock, David/0000-0002-4517-435X; Badcock,
Johanna/0000-0003-4629-2929;
FU NHMRC [403942]
FX This research was supported by NH&MRC Project Grant 403942 awarded to M.
T. Maybery, D. R. Badcock, J. C. Badcock and E. Pellicano.
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NR 50
TC 8
Z9 9
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0021-9630
J9 J CHILD PSYCHOL PSYC
JI J. Child Psychol. Psychiatry
PD JUN
PY 2010
VL 51
IS 6
BP 717
EP 724
DI 10.1111/j.1469-7610.2009.02203.x
PG 8
WC Psychology, Developmental; Psychiatry; Psychology
SC Psychology; Psychiatry
GA 594HI
UT WOS:000277526700010
PM 20070450
ER
PT J
AU Panaitof, SC
Abrahams, BS
Dong, HM
Geschwind, DH
White, SA
AF Panaitof, S. Carmen
Abrahams, Brett S.
Dong, Hongmei
Geschwind, Daniel H.
White, Stephanie A.
TI Language-related Cntnap2 Gene is Differentially Expressed in Sexually
Dimorphic Song Nuclei Essential for Vocal Learning in Songbirds
SO JOURNAL OF COMPARATIVE NEUROLOGY
LA English
DT Article
DE autism; avian; birdsong; CASPR2; contactin; neurexin; zebra finch
ID ZEBRA FINCH SONG; AUTISM-SPECTRUM DISORDERS; GANGLIA-FOREBRAIN CIRCUIT;
RECEPTOR MESSENGER-RNA; AXONAL CONNECTIONS; MYELINATED AXONS;
TELENCEPHALIC NUCLEUS; NEUREXIN SUPERFAMILY; HUMAN SPEECH; K+ CHANNELS
AB Multiple studies, involving distinct clinical populations, implicate contactin associated protein-like 2 (CNTNAP2) in aspects of language development and performance. While CNTNAP2 is broadly distributed in developing rodent brain, it shows a striking gradient of frontal cortical enrichment in developing human brain, consistent with a role in patterning circuits that subserve higher cognition and language. To test the hypothesis that CNTNAP2 may be important for learned vocal communication in additional species, we employed in situ hybridization to characterize transcript distribution in the zebra finch, an experimentally tractable songbird for which the neural substrate of this behavior is well established. Consistent with an important role in learned vocalization, Cntnap2 was enriched or diminished in key song control nuclei relative to adjacent brain tissue. Importantly, this punctuated expression was observed in males, but not females, in accord with the sexual dimorphism of neural circuitry and vocal learning in this species. Ongoing functional work will provide important insights into the relationship between Cntnap2 and vocal communication in songbirds and thereby clarify mechanisms at play in disorders of human cognition and language. J. Comp. Neurol. 518:1995-2018,2010. (C) 2010 Wiley-Liss, Inc.
C1 [Panaitof, S. Carmen; White, Stephanie A.] Univ Calif Los Angeles, Dept Physiol Sci, Los Angeles, CA 90095 USA.
[Abrahams, Brett S.; Dong, Hongmei; Geschwind, Daniel H.] Univ Calif Los Angeles, David Geffen Sch Med, Program Neurobehav Genet, Los Angeles, CA 90095 USA.
[Abrahams, Brett S.; Dong, Hongmei; Geschwind, Daniel H.] Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurol, Los Angeles, CA 90095 USA.
RP White, SA (reprint author), Univ Calif Los Angeles, Dept Physiol Sci, 621 Charles E Young Dr, Los Angeles, CA 90095 USA.
EM sawhite@ucla.edu
FU National Institutes of Health [RO1 MH070712, R21 HD06527, RO1 MH64547,
U54 MH68172, P50 HD055784]; Autism Speaks; Foundation for Psychocultural
Research
FX Grant sponsor: National Institutes of Health; Grant numbers: RO1
MH070712, R21 HD06527, RO1 MH64547, U54 MH68172, P50 HD055784; Grant
sponsor: Autism Speaks; Grant sponsor: Foundation for Psychocultural
Research.
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NR 95
TC 18
Z9 20
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0021-9967
EI 1096-9861
J9 J COMP NEUROL
JI J. Comp. Neurol.
PD JUN 1
PY 2010
VL 518
IS 11
BP 1995
EP 2018
DI 10.1002/cne.22318
PG 24
WC Neurosciences; Zoology
SC Neurosciences & Neurology; Zoology
GA 591ID
UT WOS:000277292700008
PM 20394055
ER
PT J
AU Barbaro, J
Dissanayake, C
AF Barbaro, Josephine
Dissanayake, Cheryl
TI Prospective Identification of Autism Spectrum Disorders in Infancy and
Toddlerhood Using Developmental Surveillance: The Social Attention and
Communication Study
SO JOURNAL OF DEVELOPMENTAL AND BEHAVIORAL PEDIATRICS
LA English
DT Article
DE autism spectrum disorders; developmental surveillance; screening;
infants; toddlers; prospective identification; community-based
ID TRAITS QUESTIONNAIRE ESAT; FOLLOW-UP; DIAGNOSTIC INTERVIEW;
PRESCHOOL-CHILDREN; MENTAL-RETARDATION; MODIFIED CHECKLIST; HOME
VIDEOTAPES; YOUNG-CHILDREN; ADI-R; AGE
AB Objective: Despite behavioral markers of autism spectrum disorders (ASDs) being evident within the first year of life, there remains little research on the prospective identification of these children in a community-based setting before 18 months. The aim in the Social Attention and Communication Study was to identify infants and toddlers at risk of an ASD during their first 2 years. Methods: A total of 241 Maternal and Child Health nurses were trained on the early signs of ASDs at 8, 12, 18 and 24 months. Using a developmental surveillance approach with a community-based sample, a cohort of 20,770 children was monitored on early social attention and communication behaviors. Those infants/toddlers identified as "at risk" were referred to the Social Attention and Communication Study team from 12 months for developmental and diagnostic assessments at 6 monthly intervals, until 24 months. Results: A total of 216 children were referred, with 110 being further assessed. Of these, 89 children were classified with an ASD at 24 months, and 20 children had developmental and/or language delays, resulting in a Positive Predictive value of 81%. The estimated rate of ASDs in the Social Attention and Communication Study cohort ranged from 1: 119 to 1: 233 children. Estimated sensitivity ranged from 69% to 83.8%, and estimated specificity ranged from 99.8% to 99.9%. Conclusion: Developmental surveillance of social and communication behaviors, which differ according to the age at which the child is monitored, enables the accurate identification of children at risk for ASDs between 12 and 24 months. Education on the early signs is recommended for all primary health care professionals to facilitate early identification of ASDs.
C1 [Barbaro, Josephine; Dissanayake, Cheryl] La Trobe Univ, Olga Tennison Autism Res Ctr, Sch Psychol Sci, Bundoora, Vic 3086, Australia.
RP Dissanayake, C (reprint author), La Trobe Univ, Olga Tennison Autism Res Ctr, Sch Psychol Sci, Bundoora, Vic 3086, Australia.
EM c.dissanayake@latrobe.edu.au
FU Sir Robert Menzies Memorial Foundation
FX This study was supported by a Sir Robert Menzies Memorial Foundation
Allied Health Scholarship (to J.B.).
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NR 50
TC 22
Z9 23
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0196-206X
EI 1536-7312
J9 J DEV BEHAV PEDIATR
JI J. Dev. Behav. Pediatr.
PD JUN
PY 2010
VL 31
IS 5
BP 376
EP 385
DI 10.1097/DBP.0b013e3181df7f3c
PG 10
WC Behavioral Sciences; Psychology, Developmental; Pediatrics
SC Behavioral Sciences; Psychology; Pediatrics
GA 608GE
UT WOS:000278570600002
PM 20495475
ER
PT J
AU Simons, PS
AF Simons, Paul S.
TI Assessment of Autism Spectrum Disorders
SO JOURNAL OF DEVELOPMENTAL AND BEHAVIORAL PEDIATRICS
LA English
DT Book Review
C1 [Simons, Paul S.] Univ Sch Med, Div Dev & Behav Pediat, Washington, DC USA.
RP Simons, PS (reprint author), Univ Sch Med, Div Dev & Behav Pediat, Washington, DC USA.
CR Goldstein S, 2009, ASSESSMENT AUTISM SP
NR 1
TC 0
Z9 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0196-206X
J9 J DEV BEHAV PEDIATR
JI J. Dev. Behav. Pediatr.
PD JUN
PY 2010
VL 31
IS 5
BP 413
EP 413
DI 10.1097/DBP.0b013e3181e2833c
PG 1
WC Behavioral Sciences; Psychology, Developmental; Pediatrics
SC Behavioral Sciences; Psychology; Pediatrics
GA 608GE
UT WOS:000278570600006
ER
PT J
AU Jegatheesan, B
AF Jegatheesan, Brinda
TI Muslim Children With Autism Learn to Pray
SO JOURNAL OF DEVELOPMENTAL AND BEHAVIORAL PEDIATRICS
LA English
DT Editorial Material
CR Jegatheesan B., 2005, THESIS U ILLINOIS UR
NR 1
TC 0
Z9 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0196-206X
J9 J DEV BEHAV PEDIATR
JI J. Dev. Behav. Pediatr.
PD JUN
PY 2010
VL 31
IS 5
BP 458
EP 459
DI 10.1097/DBP.0b013e3181d59470
PG 2
WC Behavioral Sciences; Psychology, Developmental; Pediatrics
SC Behavioral Sciences; Psychology; Pediatrics
GA 608GE
UT WOS:000278570600013
PM 20535085
ER
PT J
AU Reichle, J
Drager, KDR
AF Reichle, Joe
Drager, Kathryn D. R.
TI Examining Issues of Aided Communication Display and Navigational
Strategies for Young Children with Developmental Disabilities
SO JOURNAL OF DEVELOPMENTAL AND PHYSICAL DISABILITIES
LA English
DT Article
DE Augmentative and alternative communication; Aided communication; Young
children; Navigation; Display
ID AAC TECHNOLOGIES; MENTAL-RETARDATION; AUTISM; INDIVIDUALS; PERFORMANCE;
ATTENTION; LAYOUTS; DEFICIT; ADULTS; TASK
AB Gestural mode and graphic mode augmentative communication systems offer viable options for young communicators with cognitive and physical disabilities that preclude speech or result in speech that has insufficient intelligibility to be understood by a range of communicative partners. This article examines issues related to strategies of interest to interventionists that focus on navigating displays of aided communication systems utilizing displays of graphic symbols. After briefly describing aided communication systems we will differentiate between static and dynamic communicative displays. Subsequently, we will consider symbol arrangement. This will lead to discussion of a sampling of strategies that can be implemented in a dynamic communication display to facilitate navigation (including both electronic and non-electronic applications). In discussing the preceding areas, our primary emphasis will be on navigating dynamic communication displays.
C1 [Reichle, Joe] Univ Minnesota, Minneapolis, MN 55455 USA.
[Drager, Kathryn D. R.] Penn State Univ, University Pk, PA 16802 USA.
RP Reichle, J (reprint author), Univ Minnesota, Minneapolis, MN 55455 USA.
EM reich001@umn.edu
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NR 54
TC 1
Z9 1
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1056-263X
J9 J DEV PHYS DISABIL
JI J. Dev. Phys. Disabil.
PD JUN
PY 2010
VL 22
IS 3
BP 289
EP 311
DI 10.1007/s10882-010-9191-3
PG 23
WC Rehabilitation
SC Rehabilitation
GA 584AD
UT WOS:000276721500006
ER
PT J
AU Tsuchiya, KJ
Matsumoto, K
Suda, S
Miyachi, T
Itoh, H
Kanayama, N
Hirano, K
Ohzeki, T
Takei, N
AF Tsuchiya, K. J.
Matsumoto, K.
Suda, S.
Miyachi, T.
Itoh, H.
Kanayama, N.
Hirano, K.
Ohzeki, T.
Takei, N.
CA HBC Study Team
TI Searching for very early precursors of autism spectrum disorders: the
Hamamatsu Birth Cohort for Mothers and Children (HBC)
SO JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE
LA English
DT Article
DE autism; birth cohort study; child development; Japan; low birthweight;
parental age
ID PERVASIVE DEVELOPMENTAL DISORDERS; UNINTENDED PREGNANCY; POSTNATAL
DEPRESSION; PATERNAL AGE; RISK-FACTORS; SOCIOECONOMIC-STATUS;
LANGUAGE-DEVELOPMENT; EARLY-CHILDHOOD; JAPANESE WOMEN; YOUNG-CHILDREN
AB Autism spectrum disorders (ASD) are life-long neurodevelopmental conditions. The pathophysiology is poorly understood, and the clinical diagnosis can only be made through behavioural assessments. The prevalence of ASD has increased eight-fold over the last three decades. Paralleling this rise, research interest in the disorder has been accumulating, centering on two aspects: risk factors that would explain the increase in prevalence, and precursors that could predict an emergence of ASD prior to 2 years of age. As regard factors responsible for the increased prevalence, an increasing trend of low birthweight (4.2% in 1980 v. 9.6% in 2006 at Japan) and advanced paternal age at birth are potentially implicated. To explore these issues, and to yield an early diagnostic algorithm for ASD, the authors initiated the ongoing Hamamatsu Birth Cohort for Mothers and Children (HBC) in 2007. The strengths of the HBC include frequent, direct face-to-face assessments of all the participating mothers and children during the first 4 years of life (12 assessments); this depth of assessments will disclose subtle changes in the developmental domains of individuals with ASD, which might otherwise be overlooked.
A total of 1200 pregnant women are to be recruited by the end of 2010. Assembled information comprises a range of variables related to the mother's characteristics and child development. The comprehensiveness of the HBC will provide an informative data source that will elucidate early trajectories of children with ASD in addition to revealing detailed, developmental properties of typically developing children.
C1 [Tsuchiya, K. J.; Matsumoto, K.; Suda, S.; Miyachi, T.; Takei, N.] Hamamatsu Univ Sch Med, Res Ctr Child Mental Dev, Hamamatsu, Shizuoka 4313192, Japan.
[Tsuchiya, K. J.; Ohzeki, T.; Takei, N.] Kanazawa Univ, Osaka Univ, United Grad Sch Child Dev, Dept Child Dev, Hamamatsu, Shizuoka, Japan.
[Itoh, H.; Kanayama, N.] Hamamatsu Univ Sch Med, Dept Obstet & Gynaecol, Hamamatsu, Shizuoka 4313192, Japan.
[Hirano, K.; Ohzeki, T.] Hamamatsu Univ Sch Med, Dept Paediat, Hamamatsu, Shizuoka 4313192, Japan.
[Takei, N.] Kings Coll London, Inst Psychiat, Div Psychol Med, London SE5 8AF, England.
RP Tsuchiya, KJ (reprint author), Handayama 1 Higashiku, Hamamatsu, Shizuoka 4313192, Japan.
EM tsuchiya@hama-med.ac.jp
FU Ministry of Education, Culture, Sports, Science and Technology, Japan
[18591280]; National Center for Child Health and Development [21S-3,
19KOU-3]; [14370288]
FX The authors thank the following for their help and support: Dr Tetsuo
Kato of the Kato Maternity Clinic, Hamamatsu; Professor Toshihiko Terao,
the Dean of the Hamamatsu University School of Medicine; and Professor
Satoshi Nakamura, the Head of the University Hospital of the Hamamatsu
University School of Medicine. The authors also thank Dr Yoko Kamio and
Dr Makiko Okuyama for their helpful comments on maintaining the HBC.
This study was financially supported by a Grant-in-Aid for Scientific
Research from the Ministry of Education, Culture, Sports, Science and
Technology, Japan. Dr K. J. Tsuchiya is the recipient of a Grant-in-Aid
for Science Research (C) (2) (No. 18591280) and a grant for the National
Center for Child Health and Development (21S-3). Professor N. Takei is
the recipient of a Grant-in-Aid for Science Research (B) (2) (No.
14370288). Professors T. Ohzeki and N. Takei, Drs K. J. Tsuchiya and T.
Miyachi, and Kaori Matsumoto are the recipients of a grant for the
National Center for Child Health and Development (19KOU-3). The HBC
Study Team includes Ms Riyo Takabayashi, Ms Tsuruko Mori, Ms Hiroko
Muraki, Ms Chie Shimmura, Ms Noriko Kodera, Mr Shun Takahashi, Ms
Michiyo Nishizawa, Ms Yukiko Suzuki, Ms Rieko Sato, and Drs Keiko Iwata,
Anitha A. Pillai, Thanseem Ismail, Hideo Matsuzaki, Shu Takagai, Genichi
Sugihara, Mayuko Kamo, Yosuke Kameno, Mariko Shima, Yujiro Yoshihara,
Tomoyasu Wakuda, Katsuaki Suzuki, Shigeyuki Yamamoto, Masayoshi Kawai,
Kazuhiko Nakamura, Masatsugu Tsujii, Toshirou Sugiyama, Norio Mori,
Yusaku Endoh, and Teruhiko Suzuki. The authors thank Drs Kazuhiro
Sugihara, Motoi Sugimura, Kinya Takeuchi, Kazunao Suzuki, Toshiyuki
Uchida, Yasuhiro Komura, Yuusuke Murakami, Yasuhiro Koumura, Yuuki
Miyabe, Kyuya Hirai, Toshiaki Kaga, Yuki Nakamura, Rui Koizumi, Hirotake
Murakami, Yukiko Kobayashi, Ayako Mochizuki, Masako Otome, Hiroko Tajima
and all the attending obstetricians for enrolling pregnant women to
participate in the study and collecting cord blood samples. The authors
thank the chief midwife, Ms Kiyomi Hinoki and all the midwives and staff
at the maternity clinic of the Hamamatsu University School of Medicine,
for enrolling participants and facilitating recruitment. The authors
also thank Drs Yuichi Nakagawa, Satoru Iwashima, Masanori Yamamoto, Eiko
Nagata and all the paediatricians and staff at the Department of
Paediatrics at the Hamamatsu University School of Medicine for
collecting the medical history of the children, including the NICU data.
As for taking care of the participating mothers and children suffering
from difficult conditions, the authors owes much to help from local
health care professionals, including Ms Izumi Kaneko and all the public
health nurses and midwives from Hamamatsu City/ Shizuoka Prefecture, Ms
Tomoko Matsumoto at Nearai Gakuen and Dr Tomokatsu Yamazaki at Center
for Developmental Medicine, Hamamatsu City.
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NR 92
TC 8
Z9 9
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 2040-1744
J9 J DEV ORIG HLTH DIS
JI J. Dev. Orig. Health Dis.
PD JUN
PY 2010
VL 1
IS 3
BP 158
EP 173
DI 10.1017/S2040174410000140
PG 16
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 755DH
UT WOS:000289906400003
PM 25141784
ER
PT J
AU Baas, TH
van Raaij, WF
AF Baas, Tjerk H.
van Raaij, W. Fred
TI 'Familiar or risky': The Asperger syndrome affects exploratory consumer
behaviour
SO JOURNAL OF ECONOMIC PSYCHOLOGY
LA English
DT Article
DE Autism; Asperger syndrome; Consumer behaviour; Exploratory behaviour
ID OPTIMUM STIMULATION LEVEL; SPECTRUM QUOTIENT AQ; GENERAL-POPULATION;
AUTISTIC TRAITS; PERSONALITY
AB The objective of this study is to assess whether Asperger-syndrome characteristics negatively affect exploratory consumer behaviour. The Asperger syndrome is a complex autism syndrome leading to restrictions in people's (non-)verbal communication, imagination, and acquisition and maintenance of social contacts. Exploratory consumer behaviour is defined as the behaviour to discover and to try new products or services.
The results show that higher Autism-Spectrum Quotient scores, indicating the Asperger syndrome, lead to lower tendencies for exploratory consumer behaviour, both in general and on six of the seven subscales (repetitive behaviour proneness, innovativeness, risk taking, exploration through shopping, interpersonal communication, and brand switching). Asperger is not a distinct disorder, but many people have a few autism characteristics. This means that these results are relevant for a much larger group than just the people with an Asperger-syndrome diagnosis. (C) 2010 Elsevier B.V. All rights reserved.
C1 [van Raaij, W. Fred] Tilburg Univ, Sch Social Sci, NL-5000 LE Tilburg, Netherlands.
[Baas, Tjerk H.] Radboud Univ Nijmegen, Inst Appl Social Sci, NL-6525 ED Nijmegen, Netherlands.
RP van Raaij, WF (reprint author), Tilburg Univ, Sch Social Sci, POB 90153, NL-5000 LE Tilburg, Netherlands.
EM W.F.vanRaaij@uvt.nl
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NR 20
TC 0
Z9 0
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0167-4870
J9 J ECON PSYCHOL
JI J. Econ. Psychol.
PD JUN
PY 2010
VL 31
IS 3
BP 471
EP 477
DI 10.1016/j.joep.2010.02.002
PG 7
WC Economics; Psychology, Multidisciplinary
SC Business & Economics; Psychology
GA 609IF
UT WOS:000278648900019
ER
PT J
AU Rieth, CA
Huber, DE
AF Rieth, Cory A.
Huber, David E.
TI Priming and Habituation for Faces: Individual Differences and Inversion
Effects
SO JOURNAL OF EXPERIMENTAL PSYCHOLOGY-HUMAN PERCEPTION AND PERFORMANCE
LA English
DT Article
DE face perception; short-term priming; individual differences; habituation
ID CONFIGURAL INFORMATION; REPETITION BLINDNESS; SELECTIVE ATTENTION;
SYNAPTIC DEPRESSION; NEURAL-NETWORK; RECOGNITION; PERCEPTION;
INTEGRATION; MECHANISMS; AUTISM
AB Immediate repetition priming for faces was examined across a range of prime durations in a threshold identification task. Similar to word repetition priming results, short duration face primes produced positive priming whereas long duration face primes eliminated or reversed this effect. A habituation model of such priming effects predicted that the speed of identification should relate to the prime duration needed to achieve negative priming. We used face priming to test this prediction in two ways. First, we examined the relationship between priming effects and individual differences in the target duration needed for threshold performance. Second, we compared priming of upright and inverted faces. As predicted, the transition from positive to negative priming as a function of prime duration occurred more slowly for inverted faces and for individuals with longer threshold target durations. Additional experiments ruled out alternative explanations.
C1 [Rieth, Cory A.; Huber, David E.] Univ Calif San Diego, Dept Psychol, La Jolla, CA 92093 USA.
RP Rieth, CA (reprint author), Univ Calif San Diego, Dept Psychol, 0109,9500 Gilman Dr, La Jolla, CA 92093 USA.
EM crieth@ucsd.edu
FU NIMH [MH63993-01, MH063993-04]; NSF IGERT [DGE-0333451]
FX This research was supported by NIMH Grants MH63993-01, MH063993-04, and
by NSF IGERT Grant DGE-0333451 to GW Cottrell/VR de Sa. The authors
would like to thank Jim Tanaka for his generosity in allowing for the
use of his real face stimuli.
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NR 66
TC 5
Z9 5
PU AMER PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA
SN 0096-1523
J9 J EXP PSYCHOL HUMAN
JI J. Exp. Psychol.-Hum. Percept. Perform.
PD JUN
PY 2010
VL 36
IS 3
BP 596
EP 618
DI 10.1037/a0018737
PG 23
WC Psychology; Psychology, Experimental
SC Psychology
GA 602YC
UT WOS:000278174000006
PM 20515191
ER
PT J
AU Sage, KD
Jegatheesan, B
AF Sage, Kara D.
Jegatheesan, Brinda
TI Perceptions of siblings with autism and relationships with them:
European American and Asian American siblings draw and tell
SO JOURNAL OF INTELLECTUAL & DEVELOPMENTAL DISABILITY
LA English
DT Article
DE perception of autism; sibling relationship; diversity
ID SPECTRUM DISORDERS; MENTAL-RETARDATION; YOUNG-CHILDREN; DOWN-SYNDROME;
BROTHERS; SISTERS; DISABILITIES; FAMILIES; INDIVIDUALS; QUALITY
AB Background This study examined typically developing children's perceptions of their siblings with autism and their relationships with them in a European American and an Asian American family.
Method Data were drawn from interviews with the siblings using the draw-and-tell technique and participant observation in the homes of the 2 families.
Results and Conclusions Results indicate that the 2 typically developing children differed in their perceptions of their siblings with autism and their relationship with them. Results also suggest that parent involvement in providing their children with adequate knowledge about autism and its effects on their siblings with autism plays an important role in children developing a nurturing relationship with their siblings with autism.
C1 [Jegatheesan, Brinda] Univ Washington, Dept Educ Psychol, Seattle, WA 98195 USA.
[Sage, Kara D.] Univ Oregon, Eugene, OR 97403 USA.
RP Jegatheesan, B (reprint author), Univ Washington, Dept Educ Psychol, 322 J Miller,Box 353600, Seattle, WA 98195 USA.
EM brinda@u.washington.edu
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NR 55
TC 5
Z9 5
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 1366-8250
J9 J INTELLECT DEV DIS
JI J. Intellect. Dev. Dis.
PD JUN
PY 2010
VL 35
IS 2
BP 92
EP 103
DI 10.3109/13668251003712788
PG 12
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA 633ED
UT WOS:000280481400007
PM 20560697
ER
PT J
AU Mitchell, DB
Hauser-Cram, P
AF Mitchell, D. B.
Hauser-Cram, P.
TI Early childhood predictors of mothers' and fathers' relationships with
adolescents with developmental disabilities
SO JOURNAL OF INTELLECTUAL DISABILITY RESEARCH
LA English
DT Article
DE developmental disabilities; parent-child relationship; parent-adolescent
relationship; parenting stress; behaviour problems; early intervention
ID DOWN-SYNDROME ADVANTAGE; BEHAVIOR PROBLEMS; PARENTING STRESS;
INTELLECTUAL DISABILITIES; RELATIONSHIP QUALITY; SOCIOECONOMIC-STATUS;
SPECTRUM DISORDERS; PRESCHOOL-CHILDREN; YOUNG-CHILDREN; AUTISM
AB Background
The importance of positive parent-adolescent relationships is stressed in research on adolescents, although very little is known about this relationship when a teen has developmental disabilities (DD). We investigated the relationships of adolescents with disabilities with their mothers and their fathers in order to answer a number of questions regarding these relationships. In particular, we asked: are there differences in the relationships of mothers and fathers with their adolescent with DD? Are there early childhood predictors of the parent-teen relationship and are those based on variables that are amenable to intervention? Finally, do these predictors differ for mothers and fathers?
Methods
This study focused on the relationships of 72 mothers and 53 fathers with their 15-year-old teens with DD and their predictors from the early childhood years. Data were collected from parents through interviews and self-administered questionnaires, and from their children with disabilities through structured assessment when children were age 3 years and again at age 15 years.
Results
Analyses indicated that both mother-teen and father-teen relationships were predicted by earlier parenting stress. The father-teen relationship was also predicted by early behaviour problems, but this relation was mediated by parenting stress. Socio-economic status, type of disability and the child's level of functioning were not predictive of later relationships between parents and teens. Mothers and fathers did not differ significantly in their reports of perceived positive relationships with their teens.
Conclusions
The findings from this study suggest two important points of potential intervention during the early intervention years. First, parenting assistance and support to reduce stress during the early childhood years can benefit both mothers and fathers. Second, helping families and children cope with and diminish problem behaviours is likely to yield multiple advantages for parents and children and deserves emphasis in early intervention and pre-school programmes.
C1 [Mitchell, D. B.] Boston Coll, Lynch Sch Educ, Chestnut Hill, MA 02167 USA.
RP Mitchell, DB (reprint author), Boston Coll, Lynch Sch Educ, Camp Hall 239, Chestnut Hill, MA 02167 USA.
EM mitchedf@bc.edu
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NR 69
TC 3
Z9 3
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0964-2633
J9 J INTELL DISABIL RES
JI J. Intell. Disabil. Res.
PD JUN
PY 2010
VL 54
BP 487
EP 500
DI 10.1111/j.1365-2788.2010.01268.x
PN 6
PG 14
WC Education, Special; Genetics & Heredity; Clinical Neurology; Psychiatry;
Rehabilitation
SC Education & Educational Research; Genetics & Heredity; Neurosciences &
Neurology; Psychiatry; Rehabilitation
GA 596UF
UT WOS:000277710300002
PM 20367745
ER
PT J
AU Kroeger, K
Sorensen, R
AF Kroeger, K.
Sorensen, R.
TI A parent training model for toilet training children with autism
SO JOURNAL OF INTELLECTUAL DISABILITY RESEARCH
LA English
DT Article
DE autism; continence; parent training; self-initiation; toilet training;
voiding
ID PERVASIVE DEVELOPMENTAL DISORDER; DIURNAL BLADDER CONTROL; RESPONSE
RESTRICTION
AB Background
Azrin & Foxx pioneered an intensive toilet training protocol for individuals with intellectual disability living in a residential setting. Since the development of the Rapid Toilet Training (RTT) protocol, many have replicated the efficacy, most notably in educational and outpatient treatment settings, but often training over longer periods of time. This study presents data from a parent training model that replicates Azrin and Foxx's results and training time.
Method
This multiple baseline across subjects design study employs an ABA design where two boys diagnosed with autism were toilet trained using a modified Azrin & Foxx intensive teaching protocol. The first subject, a 4-year-old boy, did not have a history of attempted toilet training. The second subject, a 6-year-old boy, demonstrated a history of failed toilet training attempts in both the home and school settings. The trainings were conducted in the home setting where a novel parent-training approach was implemented.
Results
Participant 1 was continent at the end of the second day of training, and completely toilet trained (including initiation and communication) by day 10 of the intervention. Participant 2 was continent after day 1 and completely toilet trained by day 5 of the intervention.
Conclusions
Long-term follow-up demonstrates maintenance of skills 3 years post training. Social validity via parent satisfaction was assessed. Limitations to the current study and recommendations for future research were discussed.
C1 [Kroeger, K.; Sorensen, R.] Cincinnati Childrens Hosp, Med Ctr, Kelly OLeary Ctr Autism Spectrum Disorders, Cincinnati, OH USA.
RP Kroeger, K (reprint author), ML 4002,3333 Burnet Ave, Cincinnati, OH 45229 USA.
EM Kimberly.Kroeger-Geoppinger@cchmc.org
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NR 23
TC 3
Z9 5
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0964-2633
J9 J INTELL DISABIL RES
JI J. Intell. Disabil. Res.
PD JUN
PY 2010
VL 54
BP 556
EP 567
DI 10.1111/j.1365-2788.2010.01286.x
PN 6
PG 12
WC Education, Special; Genetics & Heredity; Clinical Neurology; Psychiatry;
Rehabilitation
SC Education & Educational Research; Genetics & Heredity; Neurosciences &
Neurology; Psychiatry; Rehabilitation
GA 596UF
UT WOS:000277710300008
PM 20576064
ER
PT J
AU Greimel, E
Schulte-Ruther, M
Fink, GR
Piefke, M
Herpertz-Dahlmann, B
Konrad, K
AF Greimel, E.
Schulte-Ruether, M.
Fink, G. R.
Piefke, M.
Herpertz-Dahlmann, B.
Konrad, K.
TI Development of neural correlates of empathy from childhood to early
adulthood: an fMRI study in boys and adult men
SO JOURNAL OF NEURAL TRANSMISSION
LA English
DT Article
DE fMRI; Development; Empathy; Mirror neuron system; Fusiform gyrus
ID FUSIFORM FACE AREA; MIRROR NEURON; FACIAL EXPRESSIONS;
GENDER-DIFFERENCES; AMYGDALA RESPONSE; COGNITIVE EMPATHY; SELF-FACE;
ADOLESCENCE; CHILDREN; BRAIN
AB Although empathy is rooted early in life, the ability to understand and share the emotions of others continues to develop after childhood. Here, we aimed at exploring developmental changes in the neural mechanisms underlying empathy from childhood to early adulthood. Using functional magnetic resonance imaging, 47 healthy male subjects aged 8-27 years were investigated during an explicit empathy task. Emotional faces were presented and participants were either asked to infer the emotional state from the face (other-task) or to judge their own emotional response to the face (self-task). A perceptual decision on the width of faces was used as a control condition. Age-related activity increases were observed in the fusiform gyrus and inferior frontal gyrus, depending on whether subjects attributed emotions to self or other. During the self-task, activity in the right precuneus and right intraparietal sulcus decreased as a function of age. No age-related differences were observed in behavioral performance measures. Increased activity in the fusiform gyrus and in the frontal component of the human mirror neuron system with increasing age may be explained by greater experience and expertise accumulated during socio-emotional interactions. Greater recruitment of right parietal structures in younger as compared to older subjects might reflect developmental differences in the cognitive strategies to infer one's own emotional response. This study is the first to show developmental changes in the neural mechanisms supporting empathy. Our findings may have important implications for the development of novel therapeutic interventions in clinical conditions characterized by empathy deficits, such as autism spectrum disorder.
C1 [Greimel, E.; Schulte-Ruether, M.; Konrad, K.] Rhein Westfal TH Aachen, Univ Hosp, Dept Child & Adolescent Psychiat & Psychotherapy, Child Neuropsychol Sect, D-52074 Aachen, Germany.
[Greimel, E.; Schulte-Ruether, M.; Fink, G. R.] Res Ctr Julich, Inst Neurosci & Med INM 3, Cognit Neurol Sect, D-52425 Julich, Germany.
[Fink, G. R.] Univ Hosp Cologne, Dept Neurol, D-50924 Cologne, Germany.
[Piefke, M.] Univ Bielefeld, Dept Biol, Cognit Neurosci Sect, D-33615 Bielefeld, Germany.
RP Greimel, E (reprint author), Rhein Westfal TH Aachen, Univ Hosp, Dept Child & Adolescent Psychiat & Psychotherapy, Child Neuropsychol Sect, D-52074 Aachen, Germany.
EM egreimel@ukaachen.de
RI Schulte-Ruther, Martin /F-4784-2013; Konrad, Kerstin/H-7747-2013; Fink,
Gereon/E-1616-2012
OI Schulte-Ruther, Martin /0000-0002-7198-9923; Konrad,
Kerstin/0000-0001-9039-2615; Fink, Gereon/0000-0002-8230-1856
FU MR; Cognitive Neurology groups at the Institute of Medicine (Research
Center Julich); Interdisciplinary Center of Clinical Research Aachen
(IZKF) [N68a]; German Research Foundation [IRTG 1328, DFG-KFO112-II];
German National Academic Foundation
FX We are grateful to all participants with their families who took part in
this study. We wish to thank our colleagues in the MR and Cognitive
Neurology groups at the Institute of Medicine (Research Center Julich)
for their support and helpful advice. This work was supported by the
Interdisciplinary Center of Clinical Research Aachen (IZKF, N68a; K. K.
and G. R. F.); the German Research Foundation (IRTG 1328; DFG-KFO112-II,
TP 5; K. K. B.H.-D.); and by a fellowship for doctoral students from the
German National Academic Foundation (E. G.).
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NR 70
TC 15
Z9 16
PU SPRINGER WIEN
PI WIEN
PA SACHSENPLATZ 4-6, PO BOX 89, A-1201 WIEN, AUSTRIA
SN 0300-9564
J9 J NEURAL TRANSM
JI J. Neural Transm.
PD JUN
PY 2010
VL 117
IS 6
BP 781
EP 791
DI 10.1007/s00702-010-0404-9
PG 11
WC Clinical Neurology; Neurosciences
SC Neurosciences & Neurology
GA 604NY
UT WOS:000278286900013
PM 20411397
ER
PT J
AU Cascio, CJ
AF Cascio, Carissa J.
TI Somatosensory processing in neurodevelopmental disorders
SO JOURNAL OF NEURODEVELOPMENTAL DISORDERS
LA English
DT Article
DE Touch; Development; Tactile; Sensory integration; Neurodevelopmental
disorders
ID SENSORY INTEGRATION THERAPY; MENTAL-RETARDATION SYNDROME; TO-FACE
INTERACTIONS; CEREBRAL-PALSY; TACTILE DEFENSIVENESS; MOUSE MODEL;
DEVELOPMENTAL DISORDERS; UNMYELINATED AFFERENTS; PRESCHOOL-CHILDREN;
MOTOR INTEGRATION
AB The purpose of this article is to review the role of somatosensory perception in typical development, its aberration in a range of neurodevelopmental disorders, and the potential relations between tactile processing abnormalities and central features of each disorder such as motor, communication, and social development. Neurodevelopmental disorders that represent a range of symptoms and etiologies, and for which multiple peer-reviewed articles on somatosensory differences have been published, were chosen to include in the review. Relevant studies in animal models, as well as conditions of early sensory deprivation, are also included. Somatosensory processing plays an important, yet often overlooked, role in typical development and is aberrant in various neurodevelopmental disorders. This is demonstrated in studies of behavior, sensory thresholds, neuroanatomy, and neurophysiology in samples of children with Fragile X syndrome, autism spectrum disorders (ASD), attention deficit hyperactivity disorder (ADHD), and cerebral palsy (CP). Impaired somatosensory processing is found in a range of neurodevelopmental disorders and is associated with deficits in communication, motor ability, and social skills in these disorders. Given the central role of touch in early development, both experimental and clinical approaches should take into consideration the role of somatosensory processing in the etiology and treatment of neurodevelopmental disorders.
C1 Vanderbilt Univ, Vanderbilt Kennedy Ctr Res Human Dev, Dept Psychiat, Nashville, TN 37212 USA.
RP Cascio, CJ (reprint author), Vanderbilt Univ, Vanderbilt Kennedy Ctr Res Human Dev, Dept Psychiat, 1601 23rd Ave S,Suite 3057, Nashville, TN 37212 USA.
EM carissa.cascio@vanderbilt.edu
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NR 93
TC 18
Z9 18
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1866-1947
J9 J NEURODEV DISORD
JI J. Neurodev. Disord.
PD JUN
PY 2010
VL 2
IS 2
BP 62
EP 69
DI 10.1007/s11689-010-9046-3
PG 8
WC Clinical Neurology; Neurosciences
SC Neurosciences & Neurology
GA 608JT
UT WOS:000278580700001
PM 22127855
ER
PT J
AU Losh, M
Esserman, D
Piven, J
AF Losh, Molly
Esserman, Denise
Piven, Joseph
TI Rapid automatized naming as an index of genetic liability to autism
SO JOURNAL OF NEURODEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism; Rapid automatized naming; Endophenotype; Broad autism phenotype
ID DEVELOPMENTAL DYSLEXIA; MULTIPLE-INCIDENCE; PHONOLOGICAL AWARENESS;
SUSCEPTIBILITY LOCI; CORPUS-CALLOSUM; CHILDREN; PHENOTYPE; PARENTS;
FAMILIES; LANGUAGE
AB This study investigated rapid automatized naming (RAN) ability in high functioning individuals with autism and parents of individuals with autism. Findings revealed parallel patterns of performance in parents and individuals with autism, where both groups had longer naming times than controls. Significant parent-child correlations were also detected, along with associations with language and personality features of the broad autism phenotype (retrospective reports of early language delay, socially reticent personality). Together, findings point towards RAN as a potential marker of genetic liability to autism.
C1 [Losh, Molly] Univ N Carolina, Dept Allied Hlth Sci, Chapel Hill, NC 27599 USA.
[Piven, Joseph] Univ N Carolina, Carolina Inst Dev Disabil, Chapel Hill, NC 27599 USA.
[Esserman, Denise] Univ N Carolina, Dept Med, Chapel Hill, NC 27599 USA.
RP Losh, M (reprint author), Univ N Carolina, Dept Allied Hlth Sci, Chapel Hill, NC 27599 USA.
EM molly.losh@unc.edu
FU STAART Center [U54 MH66418, R01 MH055284, K20 MH001028, K02 MH001568,
R29 MH051217]; Autism Speaks; National Science Foundation [0820394];
CTSA [UL1RR025747]
FX This project was funded by STAART Center Grant #1 U54 MH66418, R01
MH055284, K20 MH001028, K02 MH001568, and R29 MH051217 to JP. ML
acknowledges support from Autism Speaks and the National Science
Foundation (# 0820394). ML and DE acknowledge support from CTSA
UL1RR025747.
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NR 53
TC 3
Z9 3
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1866-1947
J9 J NEURODEV DISORD
JI J. Neurodev. Disord.
PD JUN
PY 2010
VL 2
IS 2
BP 109
EP 116
DI 10.1007/s11689-010-9045-4
PG 8
WC Clinical Neurology; Neurosciences
SC Neurosciences & Neurology
GA 608JT
UT WOS:000278580700006
PM 20721307
ER
PT J
AU Mostafa, GA
Shehab, AA
AF Mostafa, Gehan A.
Shehab, Abeer A.
TI The link of C4B null allele to autism and to a family history of
autoimmunity in Egyptian autistic children
SO JOURNAL OF NEUROIMMUNOLOGY
LA English
DT Article
DE Autism; Autoimmunity; Complement 4B null allele; Family history of
autoimmunity; Human leukocyte antigen
ID SYSTEMIC-LUPUS-ERYTHEMATOSUS; RHEUMATOID-ARTHRITIS; SPECTRUM DISORDERS;
RISK-FACTORS; COMPLEMENT; ASSOCIATION; DISEASE; GENES; ANTIBODIES;
HLA-DR4
AB The reason behind the initiation of autoimmunity, which may have a role in autism, is not well understood. There is an association between some autoimmune disorders and complement (C) 4B null allele. We aimed to study the association between C4B null allele and autism. In addition, we are the first to investigate the association between this allele and a family history of autoimmune diseases in autistic children. Therefore, we examined the frequency of C4B null allele, by quantitative real-time PCR, in 80 autistic patients and 80 healthy matched-children. The frequency of C4B null allele was significantly higher in autistic patients (37.5%) than healthy controls (8.75%), P<0.001. The frequency of autoimmune diseases in families of autistic children (40%) was significantly higher than healthy children (10%), P<0.001. In addition, a family history of autoimmunity had a significant risk for association with autism (odds ratio = 6, 95%, CI = 2.5-14.1). C4B null allele had a significant risk for association with autism (odds ratio = 6.26, 95% CI = 2.55-15.36) and with a family history of autoimmunity (odds ratio = 21, 95% CI = 6.5-67.8). Conclusions: the link of C4B null allele to autism and to a family history of autoimmunity may indicate its possible contributing role to autoimmunity in autism. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Mostafa, Gehan A.] Ain Shams Univ, Fac Med, Dept Pediat, Cairo, Egypt.
[Shehab, Abeer A.] Ain Shams Univ, Fac Med, Dept Clin Pathol, Cairo, Egypt.
RP Mostafa, GA (reprint author), 9 Ahmed El Samman St Makram Ebaid, Nasr City, Cairo, Egypt.
EM hafezg@softhome.net
RI zhang, jing/F-3848-2012
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NR 45
TC 24
Z9 25
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0165-5728
J9 J NEUROIMMUNOL
JI J. Neuroimmunol.
PD JUN
PY 2010
VL 223
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BP 115
EP 119
DI 10.1016/j.jneuroim.2010.03.025
PG 5
WC Immunology; Neurosciences
SC Immunology; Neurosciences & Neurology
GA 627SG
UT WOS:000280062100015
PM 20452682
ER
PT J
AU Levy, ML
Levy, KM
Hoff, D
Amar, AP
Park, MS
Conklin, JM
Baird, L
Apuzzo, MLJ
AF Levy, Michael L.
Levy, Karen M.
Hoff, Dayna
Amar, Arun Paul
Park, Min S.
Conklin, Jordan M.
Baird, Lissa
Apuzzo, Michael L. J.
TI Vagus nerve stimulation therapy in patients with autism spectrum
disorder and intractable epilepsy: results from the vagus nerve
stimulation therapy patient outcome registry Clinical article
SO JOURNAL OF NEUROSURGERY-PEDIATRICS
LA English
DT Article
DE epilepsy; epilepsy surgery; failed surgery; autism; autism spectrum
disorder; seizure; vagus nerve stimulation
ID REFRACTORY EPILEPSY; PEDIATRIC-PATIENTS; SURGERY; SEIZURES; EXPERIENCE;
CHILDHOOD; CHILDREN
AB Object. The purpose of this study was to determine the effectiveness of vagus nerve stimulation (VNS) therapy on quality-of-life (QOL) variables among patients with both autism spectrum disorder (ASD) and persistent or recurrent intractable epilepsy.
Methods. Data were obtained from the VNS therapy patient outcome registry, which was established after US FDA approval of the VNS device in 1997 as a means of capturing open-label clinical data outside of protocol. The integrity of the systems for collecting and processing registry data was authenticated by an independent auditing agency. The effect of potential selection bias, however, remains uncertain.
Results. Two cohorts were compared: 1) patients with epilepsy but without ASD (non-ASD [NASD] Group, 315 patients) who were being tracked in the registry (this cohort, which was controlled for age, included patients 20 years of age or younger); and 2) patients with a diagnosis of ASD who underwent implantation of the VNS device (ASD Group, 77 patients). Differences between the ASD and NASD groups were noted in the following categories: sex (male preponderance in ASD); normal imaging results (MR imaging results normal in ASD); depression (less common in ASD); behavioral problems (more common in ASD); neurological deficit (more common in ASD); mental retardation (more common in ASD); and developmental delay. The only QOL difference between the ASD and NASD groups was noted in mood at 12 months postimplant (mood was improved in ASD) (p = 0.04). There were no other differences in the QOL variables.
Conclusions. Patients with ASD and intractable epilepsy respond as favorably as all other patients receiving VNS therapy. In addition, they may experience a number of QOL improvements, some of which exceed those classically observed following placement of a VNS device. (DOI: 10.3171/2010.3.PEDS09153)
C1 [Levy, Michael L.; Levy, Karen M.; Hoff, Dayna; Park, Min S.; Conklin, Jordan M.; Baird, Lissa] Univ Calif San Diego, Div Pediat Neurosurg, Childrens Hosp San Diego, San Diego, CA 92103 USA.
[Amar, Arun Paul; Apuzzo, Michael L. J.] Univ So Calif, Keck Sch Med, Dept Neurosurg, Los Angeles, CA 90033 USA.
RP Levy, ML (reprint author), Rady Childrens Hosp San Diego, Div Pediat Neurosurg, 8010 Frost St,Suite 502, San Diego, CA 92123 USA.
EM mlevy@chsd.org
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NR 26
TC 6
Z9 6
PU AMER ASSOC NEUROLOGICAL SURGEONS
PI ROLLING MEADOWS
PA 5550 MEADOWBROOK DRIVE, ROLLING MEADOWS, IL 60008 USA
SN 1933-0707
J9 J NEUROSURG-PEDIATR
JI J. Neurosurg.-Pediatr.
PD JUN
PY 2010
VL 5
IS 6
BP 595
EP 602
DI 10.3171/2010.3.PEDS09153
PG 8
WC Clinical Neurology; Pediatrics; Surgery
SC Neurosciences & Neurology; Pediatrics; Surgery
GA 600YF
UT WOS:000278024200011
PM 20515333
ER
PT J
AU Yap, IKS
Angley, M
Veselkov, KA
Holmes, E
Lindon, JC
Nicholson, JK
AF Yap, Ivan K. S.
Angley, Manya
Veselkov, Kirill A.
Holmes, Elaine
Lindon, John C.
Nicholson, Jeremy K.
TI Urinary Metabolic Phenotyping Differentiates Children with Autism from
Their Unaffected Siblings and Age-Matched Controls
SO JOURNAL OF PROTEOME RESEARCH
LA English
DT Article
DE autism; microbial co-metabolites; metabonomics; metabolic profiling;
metabolic phenotype; gut microbiota; NMR; pattern recognition
ID SPECTRUM DISORDERS; PARKINSONS-DISEASE; COMPLEX-I;
LIQUID-CHROMATOGRAPHY; OXIDATIVE STRESS; GUT MICROBIOTA; HEALTH-CARE;
RAT; IDENTIFICATION; PLASMA
AB Autism is an early onset developmental disorder with a severe life-long impact on behavior and social functioning that has associated metabolic abnormalities. The urinary metabolic phenotypes of individuals (age range=3-9 years old) diagnosed with autism using the DSM-IV-TR criteria (n = 39; male = 35; female = 4), together with their nonautistic siblings (n = 28; male = 14; female = 14) and age-matched healthy volunteers (n = 34, male = 17; female = 17) have been characterized for the first time using (1)H NMR spectroscopy and pattern recognition methods. Novel findings associated with alterations in nicotinic acid metabolism within autistic individuals showing increased urinary excretion of N-methyl-2-pyridone-5-carboxamide, N-methyl nicotinic acid, and N-methyl nicotinamide indicate a perturbation in the tryptophan-nicotinic acid metabolic pathway. Multivariate statistical analysis indicated urinary patterns of the free amino acids, glutamate and taurine were significantly different between groups with the autistic children showing higher levels of urinary taurine and a lower level of urinary glutamate, indicating perturbation in sulfur and amino acid metabolism in these children. Additionally, metabolic phenotype (metabotype) differences were observed between autistic and control children, which were associated with perturbations in the relative patterns of urinary mammalian-microbial cometabolites including dimethylamine, hippurate, and phenyacetylglutamine. These biochemical changes are consistent with some of the known abnormalities of gut microbiota found in autistic individuals and the associated gastrointestinal dysfunction and may be of value in monitoring the success of therapeutic interventions.
C1 [Yap, Ivan K. S.; Angley, Manya; Veselkov, Kirill A.; Holmes, Elaine; Lindon, John C.; Nicholson, Jeremy K.] Univ London Imperial Coll Sci Technol & Med, Fac Med, Div Surg & Canc, London SW7 2AZ, England.
[Angley, Manya] Univ S Australia, Div Hlth Sci, Sansom Inst, Adelaide, SA 5001, Australia.
RP Nicholson, JK (reprint author), Univ London Imperial Coll Sci Technol & Med, Fac Med, Div Surg & Canc, Alexander Fleming Bldg,S Kensington Campus, London SW7 2AZ, England.
EM j.nicholson@imperial.ac.uk
RI Yap, Ivan/C-9325-2013; Nicholson, Jeremy/B-3395-2012
OI Nicholson, Jeremy/0000-0002-8123-8349
FU Cure Autism Now (CAN); International Study of Macro/micronutrients and
Blood Pressure [1-R0I-HL084228-01A1]
FX We thank the Autism Research Group, Sansom Institute, Division of Health
Sciences, University of South Australia and the Swiss Tropical Institute
for urine sample provision. Cure Autism Now (CAN) provided the funding
for collection of the urine samples for metabonomic purposes in
2006/2007. We would also like to acknowledge Lv Wang from University of
South Australia for her contribution in providing epidemiological data
for this study. Our thanks also to Dr. D. Granpeesheh (C.A.R.D, Los
Angeles, Ca.) for helpful discussions on the manuscript and related
data. This work received financial support from the International Study
of Macro/micronutrients and Blood Pressure grant (1-R0I-HL084228-01A1)
to I.K.S.Y.
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NR 64
TC 83
Z9 86
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1535-3893
J9 J PROTEOME RES
JI J. Proteome Res.
PD JUN
PY 2010
VL 9
IS 6
BP 2996
EP 3004
DI 10.1021/pr901188e
PG 9
WC Biochemical Research Methods
SC Biochemistry & Molecular Biology
GA 603YF
UT WOS:000278243300020
PM 20337404
ER
PT J
AU Volker, MA
Lopata, C
Vujnovic, RK
Smerbeck, AM
Toomey, JA
Rodgers, JD
Schiavo, A
Thomeer, ML
AF Volker, Martin A.
Lopata, Christopher
Vujnovic, Rebecca K.
Smerbeck, Audrey M.
Toomey, Jennifer A.
Rodgers, Jonathan D.
Schiavo, Audrey
Thomeer, Marcus L.
TI Comparison of the Bender Gestalt-II and VMI-V in Samples of Typical
Children and Children with High-Functioning Autism Spectrum Disorders
SO JOURNAL OF PSYCHOEDUCATIONAL ASSESSMENT
LA English
DT Article
DE motor skills; visual-motor; Bender Gestalt Test-II; Developmental Test
of Visual-Motor Integration; high-functioning autism; Asperger's
disorder
ID VISUAL-MOTOR INTEGRATION; REGULAR EDUCATION STUDENTS; REVISED
DEVELOPMENTAL TEST; ASPERGER-SYNDROME; TEST USAGE; PERFORMANCE; TESTS;
SCORES
AB The visual-motor skills of 60 children with high-functioning autism spectrum disorders (HFASDs) and 46 typically developing children were assessed using the Bender Visual-Motor Gestalt Test-Second Edition (BG-II) and Beery-Buktenica Developmental Test of Visual-Motor Integration, Fifth Edition (VMI-V). Within-group comparisons yielded substantive mean differences between the BG-II Copy score and VMI-V composite,Visual Perception and Motor Coordination sections of the VMI-V, and Copy and Recall sections of the BG-II, in both samples. Between-groups differences were assessed in a subsample of 27 participants from each group matched on age, gender, ethnicity, and parent education. After statistically controlling for IQ, the HFASD group scored significantly lower than the typically developing group on the two scores from each test with greater motor involvement. Intratest and intertest correlations were similar across the two samples. Correlations between the BG-II Copy score and VMI-V composite were .55 for the HFASD and .48 for the typically developing sample.
C1 [Volker, Martin A.; Vujnovic, Rebecca K.; Smerbeck, Audrey M.; Rodgers, Jonathan D.] SUNY Buffalo, Dept Counseling Sch & Educ Psychol, Buffalo, NY 14260 USA.
[Lopata, Christopher; Thomeer, Marcus L.] Canisius Coll, Inst Autism Res, Buffalo, NY 14208 USA.
[Toomey, Jennifer A.; Schiavo, Audrey] Summit Educ Resources, Getzville, NY USA.
RP Volker, MA (reprint author), SUNY Buffalo, Dept Counseling Sch & Educ Psychol, 409 Christopher Baldy Hall, Buffalo, NY 14260 USA.
EM mvolker@buffalo.edu
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NR 33
TC 3
Z9 4
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0734-2829
J9 J PSYCHOEDUC ASSESS
JI J. Psychoeduc. Assess.
PD JUN
PY 2010
VL 28
IS 3
BP 187
EP 200
DI 10.1177/0734282909348216
PG 14
WC Psychology, Educational
SC Psychology
GA 598BH
UT WOS:000277806500001
ER
PT J
AU McGuinness, TM
Lewis, S
AF McGuinness, Teena M.
Lewis, Shannon
TI Update on Autism and Vaccines
SO JOURNAL OF PSYCHOSOCIAL NURSING AND MENTAL HEALTH SERVICES
LA English
DT Article
ID DIAGNOSTIC SUBSTITUTION; DISORDER; TRENDS
AB As the rate of autism spectrum disorders rises, parents are searching for answers. In this article, a small study that fueled the belief in an association between autism and vaccines is reviewed, and the scientific evidence regarding the relationship between autism and vaccines is explored.
C1 [McGuinness, Teena M.; Lewis, Shannon] Univ Alabama, Sch Nursing, Birmingham, AL 35294 USA.
RP McGuinness, TM (reprint author), Univ Alabama, Sch Nursing, NB 320,1530 3rd Ave S, Birmingham, AL 35294 USA.
EM tmcg@uab.edu
CR [Anonymous], 2010, LANCET, V375, P445
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Wakefield AJ, 1998, LANCET, V351, P637, DOI 10.1016/S0140-6736(97)11096-0
NR 18
TC 1
Z9 1
PU SLACK INC
PI THOROFARE
PA 6900 GROVE RD, THOROFARE, NJ 08086 USA
SN 0279-3695
J9 J PSYCHOSOC NURS MEN
JI J. Psychosoc. Nurs. Ment. Health Serv.
PD JUN
PY 2010
VL 48
IS 6
BP 15
EP 18
DI 10.3928/02793695-20100506-02
PG 4
WC Nursing
SC Nursing
GA 610OZ
UT WOS:000278744300007
ER
PT J
AU Grossman, RB
Bemis, RH
Skwerer, DP
Tager-Flusberg, H
AF Grossman, Ruth B.
Bemis, Rhyannon H.
Skwerer, Daniela Plesa
Tager-Flusberg, Helen
TI Lexical and Affective Prosody in Children With High-Functioning Autism
SO JOURNAL OF SPEECH LANGUAGE AND HEARING RESEARCH
LA English
DT Article
DE autism; prosody; lexical stress; affective prosody; perception;
production
ID PERVASIVE DEVELOPMENTAL DISORDERS; SPECTRUM DISORDERS; REVISED VERSION;
VOCAL EMOTION; SPEECH; STRESS; LANGUAGE; ADOLESCENTS; EXPRESSION; ADULTS
AB Purpose: To investigate the perception and production of lexical stress and processing of affective prosody in adolescents with high-functioning autism (HFA). We hypothesized preserved processing of lexical and affective prosody but atypical lexical prosody production.
Method: Sixteen children with HFA and 15 typically developing (TD) peers participated in 3 experiments that examined the following: (a) perception of affective prosody (Experiment 1), (b) lexical stress perception (Experiment 2), and (c) lexical stress production (Experiment 3). In Experiment 1, participants labeled sad, happy, and neutral spoken sentences that were low-pass filtered, to eliminate verbal content. In Experiment 2, participants disambiguated word meanings based on lexical stress (HOTdog vs. hot DOG). In Experiment 3, participants produced these words in a sentence completion task. Productions were analyzed with acoustic measures.
Results: Accuracy levels showed no group differences. Participants with HFA could determine affect from filtered sentences and disambiguate words on the basis of lexical stress. They produced appropriately differentiated lexical stress patterns but demonstrated atypically long productions, indicating reduced ability in natural prosody production.
Conclusions: Children with HFA were as capable as their TD peers in receptive tasks of lexical stress and affective prosody. Prosody productions were atypically long, despite accurate differentiation of lexical stress patterns. Future research should use larger samples and spontaneous versus elicited productions.
C1 [Grossman, Ruth B.] Univ Massachusetts, Sch Med, Shriver Ctr, Waltham, MA USA.
[Bemis, Rhyannon H.] Univ New Hampshire, Durham, NH 03824 USA.
[Skwerer, Daniela Plesa; Tager-Flusberg, Helen] Boston Univ, Sch Med, Boston, MA 02118 USA.
RP Grossman, RB (reprint author), Emerson Coll, Dept Commun Sci & Disorders, 120 Boylston St, Boston, MA 02116 USA.
EM ruth_grossman@emerson.edu
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NR 54
TC 35
Z9 35
PU AMER SPEECH-LANGUAGE-HEARING ASSOC
PI ROCKVILLE
PA 10801 ROCKVILLE PIKE, ROCKVILLE, MD 20852-3279 USA
SN 1092-4388
J9 J SPEECH LANG HEAR R
JI J. Speech Lang. Hear. Res.
PD JUN 1
PY 2010
VL 53
IS 3
BP 778
EP 793
DI 10.1044/1092-4388(2009/08-0127)
PG 16
WC Audiology & Speech-Language Pathology; Linguistics; Rehabilitation
SC Audiology & Speech-Language Pathology; Linguistics; Rehabilitation
GA 607GV
UT WOS:000278488000017
PM 20530388
ER
PT J
AU Qiu, AQ
Adler, M
Crocetti, D
Miller, MI
Mostofsky, SH
AF Qiu, Anqi
Adler, Marcy
Crocetti, Deana
Miller, Michael I.
Mostofsky, Stewart H.
TI Basal Ganglia Shapes Predict Social, Communication, and Motor
Dysfunctions in Boys With Autism Spectrum Disorder
SO JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
LA English
DT Article
DE magnetic resonance imaging; large deformation diffeomorphic metric
mapping (LDDMM); frontal; striatal; praxis
ID HIGH-FUNCTIONING AUTISM; ASPERGERS-SYNDROME; CAUDATE-NUCLEUS; METRIC
MAPPINGS; CORTICAL INPUTS; PREMOTOR AREAS; HUMAN BRAIN; TOOL USE;
CHILDREN; CORTEX
AB Objective: Basal ganglia abnormalities have been suggested as contributing to motor, social, and communicative impairments in autism spectrum disorder (ASD). Volumetric analyses offer limited ability to detect localized differences in basal ganglia structure. Our objective was to investigate basal ganglia shape abnormalities and their association with behavioral features of ASD, which may involve multiple frontal subcortical circuits. Method: Basal ganglia were manually delineated from MR images of 32 boys with ASD and 45 typically developing (TD) boys. Large deformation diffeomorphic metric mapping (LDDMM) was used to assess between-group differences in basal ganglia shape and to examine associations with motor, praxis, and reciprocal social and communicative impairments in ASD. Results: Boys with ASD showed changes in right basal ganglia shape as compared with TD boys; surface deformation was present in the caudate, putamen, and globus pallidus but did not stand up to correction for multiple comparisons. Brain-behavior correlation findings were more robust; analyses accounting for multiple comparisons revealed, in boys with ASD, surface inward deformation of the right posterior putamen predicted poorer motor skill, whereas surface inward deformation of the bilateral anterior and posterior putamen predicted poorer praxis. Surface outward deformation in the bilateral medial caudate head predicted greater reciprocal social and communicative impairment. Conclusions: Motor, social, and communicative impairments in boys with ASD are associated with shape abnormalities in the basal ganglia. The findings suggest abnormalities within parallel frontal subcortical circuits are differentially associated with impaired acquisition of motor and reciprocal social and communicative skills in ASD. J. Am. Acad. Child Adolesc. Psychiatry, 2010;49(6):539-551.
C1 [Qiu, Anqi] Natl Univ Singapore, Div Bioengn, Singapore 117574, Singapore.
[Qiu, Anqi] Natl Univ Singapore, Clin Imaging Res Ctr, Singapore 117574, Singapore.
[Qiu, Anqi] Singapore Inst Clin Sci, Singapore, Singapore.
[Miller, Michael I.; Mostofsky, Stewart H.] Johns Hopkins Univ, Baltimore, MD 21218 USA.
RP Qiu, AQ (reprint author), Natl Univ Singapore, Div Bioengn, 9 Engn Dr 1,Block EA 03-12, Singapore 117574, Singapore.
EM bieqa@nus.edu.sg
RI Miller, Michael I./A-3213-2010; Qiu, Anqi/H-2267-2011
FU National Alliance for Autism Research, Autism Speaks; National
University of Singapore [R-397-000-058-133]; A*STAR SERC [SERC 082 101
0025, SICS-09/1/1/001]; National Institutes of Health (NIH) [R01
NS048527, K02 NS044850, P41 RR15241]; Developmental Disabilities
Research Center [HD-24061]; Johns Hopkins University School of Medicine
Institute for Clinical and Translational Research; NIH/ NCRR
[UL1-RRO25005]
FX Work was supported by the National Alliance for Autism Research, Autism
Speaks, the National University of Singapore start-up grant
R-397-000-058-133 (AQ), A*STAR SERC 082 101 0025 (AQ), A*STAR
SICS-09/1/1/001 (AQ), and National Institutes of Health (NIH) grants R01
NS048527 (S.H.M.), K02 NS044850 (S.H.M.), P41 RR15241 (M.I.M), the
Developmental Disabilities Research Center (HD-24061), and the Johns
Hopkins University School of Medicine Institute for Clinical and
Translational Research, an NIH/ NCRR CTSA Program (UL1-RRO25005).
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NR 73
TC 36
Z9 36
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0890-8567
J9 J AM ACAD CHILD PSY
JI J. Am. Acad. Child Adolesc. Psychiatr.
PD JUN
PY 2010
VL 49
IS 6
BP 539
EP 551
DI 10.1016/j.jaac.2010.02.012
PG 13
WC Psychology, Developmental; Pediatrics; Psychiatry
SC Psychology; Pediatrics; Psychiatry
GA 602TA
UT WOS:000278160500002
PM 20494264
ER
PT J
AU Groen, W
Teluij, M
Buitelaar, J
Tendolkar, I
AF Groen, Wouter
Teluij, Michelle
Buitelaar, Jan
Tendolkar, Indira
TI Amygdala and Hippocampus Enlargement During Adolescence in Autism
SO JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
LA English
DT Article
DE autism; emotion; amygdala; hippocampus
ID POSTTRAUMATIC-STRESS-DISORDER; RECURRENT MAJOR DEPRESSION;
TEMPORAL-LOBE; SPECTRUM DISORDERS; EMOTION PERCEPTION; CEREBRAL-CORTEX;
YOUNG-CHILDREN; HUMAN BRAIN; VOLUMES; MRI
AB Objective: The amygdala and hippocampus are key components of the neural system mediating emotion perception and regulation and are thought to be involved in the pathophysiology of autism. Although some studies in children with autism suggest that there is an enlargement of amygdala and hippocampal volume, findings in adolescence are sparse. Method: We measured amygdala and hippocampus volume in a homogeneous group of adolescents with autism (12 through18 years; n = 23) and compared them with an age-, sex-, and IQ-matched control group (n = 29) using a validated automated segmentation procedure in 1.5-T magnetic resonance images. All analyses were adjusted for total brain volume. Results: Repeated-measures analysis revealed a significant group x hemisphere x brain structure interaction (p = .038), even when corrected for total brain volume. Post-hoc analysis showed that the right amygdala and left hippocampus were significantly enlarged (p = .010; p = .015) in the autism compared with the control group. There were no significant correlations between age and amygdala or hippocampus volume. Conclusions: The abnormal enlargement of the amygdala and hippocampus in adolescents with autism adds to previous findings of enlargement of these structures in children with autism. This may reflect increased activity of these structures and thereby altered emotion perception and regulation. Our results could therefore be interpreted in light of developmental adaptation of the autistic brain to a continuous overflow of emotional learning experiences. J. Am. Acad. Child Adolesc. Psychiatry, 2010;49(6):552-560.
C1 [Groen, Wouter] Radboud Univ Nijmegen, Med Ctr, Dept Psychiat, NL-6500 HB Nijmegen, Netherlands.
RP Groen, W (reprint author), Radboud Univ Nijmegen, Med Ctr, Dept Psychiat, Reinier Postlaan 10,POB 9101, NL-6500 HB Nijmegen, Netherlands.
EM groen@psy.umcn.nl
RI Tendolkar, Indira/F-1167-2010; Buitelaar, Jan/E-4584-2012
OI Buitelaar, Jan/0000-0001-8288-7757
FU Shire
FX Disclosure: Dr. Buitelaar has served as a consultant and on the advisory
board for Shire, Janssen Cilag, Eli Lilly, Pfizer, Organon, UCB,
Servier, and Otsuka. He has served on the speakers' bureau for Janssen
Cilag and Eli Lilly. He has received research support from Shire. Drs.
Groen, Teluij, and Tendolkar report no biomedical financial interests or
potential conflicts of interest.
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NR 44
TC 32
Z9 33
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0890-8567
J9 J AM ACAD CHILD PSY
JI J. Am. Acad. Child Adolesc. Psychiatr.
PD JUN
PY 2010
VL 49
IS 6
BP 552
EP 560
DI 10.1016/j.jaac.2009.12.023
PG 9
WC Psychology, Developmental; Pediatrics; Psychiatry
SC Psychology; Pediatrics; Psychiatry
GA 602TA
UT WOS:000278160500003
PM 20494265
ER
PT J
AU Liu, AY
Li, QZ
Liu, CL
Yu, K
Yu, KF
AF Liu, Aiyi
Li, Qizhai
Liu, Chunling
Yu, Kai
Yu, Kai F.
TI A Rank-Based Test for Comparison of Multidimensional Outcomes
SO JOURNAL OF THE AMERICAN STATISTICAL ASSOCIATION
LA English
DT Article
DE Autism spectrum disorder; Behrens-Fisher problem; Cardioprotective
solution; Case-control studies; Growth hormones; Multiple outcomes;
Nonparametrics; Rank-sum statistics
ID BEHRENS-FISHER PROBLEM; MULTIPLE END-POINTS; EXPONENTIAL DISTRIBUTION;
TRIALS
AB For comparison of multiple outcomes commonly encountered in biomedical research, Huang et al. (2005) improved O'Brien's (1984) rank-sum tests through the replacement of the ad hoc variance by the asymptotic variance of the test statistics. The improved tests control the type I error rate at the desired level and gain power when the differences between the two comparison groups in each outcome variable lie in the same direction; however, they may lose power when the differences are in different directions (e.g., some are positive and some are negative). These tests and the popular Bonferroni correction failed to show important significant differences when applied to compare heart rates from a clinical trial to evaluate the effect of a procedure to remove the cardioprotective solution HTK. We propose an alternative test statistic, taking the maximum of the individual rank-sum statistics, which controls the type I error rate and maintains satisfactory power regardless of the direction of the differences. Simulation studies show the proposed test to be of higher power than other tests in a certain alternative parameter space of interest. Furthermore, when used to analyze the heart rate data, the proposed test yields more satisfactory results.
C1 [Liu, Aiyi; Liu, Chunling; Yu, Kai F.] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Rockville, MD 20852 USA.
[Li, Qizhai] Chinese Acad Sci, Acad Math & Syst Sci, Key Lab Syst & Control, Beijing 100190, Peoples R China.
[Yu, Kai F.] Natl Canc Inst, Rockville, MD 20852 USA.
RP Liu, AY (reprint author), Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Rockville, MD 20852 USA.
EM liua@mail.nih.gov
FU Eunice Kennedy Shriver National Institute of Child Health and Human
Development; National Cancer Institute; National Young Science
Foundation of China [10901155]
FX Aiyi Liu is Senior Investigator, Eunice Kennedy Shriver National
Institute of Child Health and Human Development, Rockville, MD 20852
(E-mail: liva@mail.nih.gov). Qizhai Li is Assistant Professor, Key
Laboratory of Systems and Control, Academy of Mathematics and Systems
Science, Chinese Academy of Sciences, Beijing, 100190, China. Chunling
Liu is Postdoctoral Fellow, Eunice Kennedy Shriver National Institute of
Child Health and Human Development, Rockville, MD 20852. Kai Yu is
Investigator, National Cancer Institute, Rockville, MD 20852. Kai F. Yu
is Senior Investigator, Eunice Kennedy Shriver National Institute of
Child Health and Human Development. This research was supported by the
Intramural Research Program of the Eunice Kennedy Shriver National
Institute of Child Health and Human Development and the National Cancer
Institute. The research of Qizhai Li was partially supported by the
National Young Science Foundation of China (grant 10901155). The authors
thank two referees, an associate editor, and the editor for their
thoughtful comments and suggestions that improved the article, and Dr.
B. J. Stone for reading the manuscript.
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PU AMER STATISTICAL ASSOC
PI ALEXANDRIA
PA 732 N WASHINGTON ST, ALEXANDRIA, VA 22314-1943 USA
SN 0162-1459
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PD JUN
PY 2010
VL 105
IS 490
BP 578
EP 587
DI 10.1198/jasa.2010.ap09114
PG 10
WC Statistics & Probability
SC Mathematics
GA 629RF
UT WOS:000280216700011
ER
PT J
AU Lott, IT
Dierssen, M
AF Lott, Ira T.
Dierssen, Mara
TI Cognitive deficits and associated neurological complications in
individuals with Down's syndrome
SO LANCET NEUROLOGY
LA English
DT Review
ID HIGH-RESOLUTION MRI; ATHEROMA-FREE MODEL; ALZHEIMERS-DISEASE;
MENTAL-RETARDATION; WORKING-MEMORY; MOUSE MODEL; INFANTILE SPASMS;
RISK-FACTORS; CONGENITAL HYPOTHYROIDISM; GENETIC-DISORDERS
AB Improvements in medical interventions for people with Down's syndrome have led to a substantial increase in their longevity. Diagnosis and treatment of neurological complications are important in maintaining optimal cognitive functioning. The cognitive phenotype in Down's syndrome is characterised by impairments in morphosyntax, verbal short-term memory, and explicit long-term memory. However, visuospatial short-term memory, associative learning, and implicit long-term memory functions are preserved. Seizures are associated with cognitive decline and seem to cause additional decline in cognitive functioning, particularly in people with Down's syndrome and comorbid disorders such as autism. Vision and hearing disorders as well as hypothyroidism can negatively impact cognitive functioning in people with Down's syndrome. Dementia that resembles Alzheimer's disease is common in adults with Down's syndrome. Early-onset dementia in adults with Down's syndrome does not seem to be associated with atherosclerotic complications.
C1 [Lott, Ira T.] Univ Calif Irvine, Sch Med, Dept Pediat, Orange, CA 92868 USA.
[Lott, Ira T.] Univ Calif Irvine, Sch Med, Dept Neurol, Orange, CA 92868 USA.
[Dierssen, Mara] Ctr Genom Regulat, Gene & Dis Program, Barcelona, Spain.
[Dierssen, Mara] CIBER Enfermedades Raras, Barcelona, Spain.
RP Lott, IT (reprint author), Univ Calif Irvine, Sch Med, Dept Pediat, Orange, CA 92868 USA.
EM itlott@uci.edu
FU National Institute Aging [AG 16573]; Generalitat de Catalunya
[2009SGR1313]; Spanish Ministry of Science and Technology
[SAF2007-60827, SAF2007-31093-E]; Fondo de Investigacion Sanitaria [PI
082038]; Marato TV3 [062230]; Jerome Lejeune Foundation
[JMLM/AC/08-044]; Areces Foundation; Reina Sofia Foundation; European
Union [LSHG-CT-2006-037627, EU/FIS PS09102673]
FX Our work is supported in part by grants from the National Institute
Aging (AG 16573), the Generalitat de Catalunya (2009SGR1313), the
Spanish Ministry of Science and Technology (SAF2007-60827,
SAF2007-31093-E), Fondo de Investigacion Sanitaria (PI 082038), Marato
TV3 (062230), the Jerome Lejeune Foundation (JMLM/AC/08-044), the Areces
Foundation, the Reina Sofia Foundation, and the European Union
(LSHG-CT-2006-037627; EU/FIS PS09102673). We are grateful to Eric Doran
for editorial assistance in the preparation of this manuscript.
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NR 155
TC 79
Z9 81
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1474-4422
J9 LANCET NEUROL
JI Lancet Neurol.
PD JUN
PY 2010
VL 9
IS 6
BP 623
EP 633
PG 11
WC Clinical Neurology
SC Neurosciences & Neurology
GA 607NY
UT WOS:000278512000015
PM 20494326
ER
PT J
AU Wechsler, S
AF Wechsler, Stephen
TI WHAT 'YOU' AND 'I' MEAN TO EACH OTHER: PERSON INDEXICALS,
SELF-ASCRIPTION, AND THEORY OF MIND
SO LANGUAGE
LA English
DT Article
DE indexical; person; pronoun; theory of mind; self-reference; acquisition;
autism
ID BELIEF; PRONOUNS; REPRESENTATION; ACQUISITION; LANGUAGE; SPEECH; CHILD
AB This article offers a DE SE THEORY of person indexicals, wherein first- and second-person indexical pronouns indicate REFERENCE DE SE (also called SELF-ASCRIPTION). Long observed for first-person pronouns (Castaneda 1977, Kaplan 1977, Perry 1979, inter alia), self-ascription is extended here to second person as well. The person feature of a pronoun specifies the speech-act roles that must be played by the self-ascribers: the speakers (uttering a first-person pronoun), the addressees (interpreting a second-person pronoun), or both (for first-person inclusive). Other agents who are not among the designated self-ascribers for a given pronoun interpret the pronoun indirectly by inferring the self-ascriber's interpretation, a process requiring THEORY OF MIND, that is, the cognitive ability to impute mental states to others (Premack & Woodruff 1978). This de se theory is supported by convergent evidence from multiple domains: (i) It explains a typological universal: first- and second-person plurals always allow associative semantics ('speaker(s) plus others', 'addressee(s) plus others') rather than requiring regular plural semantics ('speakers only', 'addressees only') (Greenberg 1988, Noyer 1992, Cysouw 2003, Bobaljik 2008). (ii) It belongs to a family of approaches that solve the problem of the essential indexical (Perry 1979). (iii) It correctly predicts observed patterns of indexical pronoun production and comprehension by two populations lacking a fully developed theory of mind: typically developing children in the stage before theory of mind has developed, and children with autism. (iv) It correctly predicts the interpretation of second-person pronouns in utterances with multiple addressees.*
C1 Univ Texas Austin, Dept Linguist, Austin, TX 78712 USA.
RP Wechsler, S (reprint author), Univ Texas Austin, Dept Linguist, 1 Univ Stn B5100, Austin, TX 78712 USA.
EM wechsler@mail.utexas.edu
CR Anand P., 2004, P SALT, P20
ANAND P, 2006, DE DE SE
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NR 81
TC 13
Z9 13
PU LINGUISTIC SOC AMER
PI WASHINGTON
PA 1325 18TH ST NW, SUITE 211, WASHINGTON, DC 20036-6501 USA
SN 0097-8507
J9 LANGUAGE
JI Language
PD JUN
PY 2010
VL 86
IS 2
BP 332
EP 365
PG 34
WC Linguistics; Language & Linguistics
SC Linguistics
GA 611GS
UT WOS:000278801000003
ER
PT J
AU Chamak, B
AF Chamak, Brigitte
TI Autism: overestimation of the genetic origins
SO M S-MEDECINE SCIENCES
LA French
DT Article
ID AFFECTED SIBLING PAIRS; SPECTRUM DISORDERS; RISK-FACTORS;
INFANTILE-AUTISM; TWIN; MUTATIONS; ETIOLOGY; LINKAGE; NLGN4
AB Autism: overestimation of the genetic origins
Since the 1990s the genetic causes of autism have been brought to the fore. Despite scientific efforts and huge fundings, less than 20% of cases of autism have been linked to genetic abnormalities. These results do not slow the spread of discourse on the genetic origin of autism, and the concomitant neglect of risks linked to perinatal factors. A detailed analysis of results and assertions in favour of a strong genetic origin of autism reveals methodological biases, misinterpretations and erroneous approximations, as well as an exaggerated media coverage. Studies on twins are illustrative of these biases. The recent demonstration of an excess of twins among sibling pairs with autism, and especially a 10-fold increase for monozygotic twins compared with the general population frequencies, has questioned the relevance of conclusions from earlier twin studies. Indeed, if being a twin is a risk factor for autism, then there may be an upwards bias in estimates of the genetic contribution to autism, and the intrauterine environment, including competition for nutrients, has been neglected.
C1 Univ Paris 05, INSERM, Ctr Rech Med Sci Sante Sante Mentale & Soc, CERMES3 CESAMES,EHESS,CNRS,UMR8211, F-75006 Paris 06, France.
RP Chamak, B (reprint author), Univ Paris 05, INSERM, Ctr Rech Med Sci Sante Sante Mentale & Soc, CERMES3 CESAMES,EHESS,CNRS,UMR8211, 45 Rue St Peres, F-75006 Paris 06, France.
EM brigitte.chamak@parisdescartes.fr
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PARIS STUDY
NR 30
TC 6
Z9 6
PU EDITIONS EDK
PI SEVRES CEDEX
PA 2 RUE TROYON, SEVRES CEDEX, 92316, FRANCE
SN 0767-0974
J9 M S-MED SCI
JI M S-Med. Sci.
PD JUN-JUL
PY 2010
VL 26
IS 6-7
BP 659
EP 662
DI 10.1051/medsci/2010266-7659
PG 4
WC Medicine, Research & Experimental
SC Research & Experimental Medicine
GA 630UV
UT WOS:000280301200024
PM 20619172
ER
PT J
AU Murza, KA
Pavelko, SL
Malani, MD
Nye, C
AF Murza, Kimberly A.
Pavelko, Stacey L.
Malani, Melissa D.
Nye, Chad
TI Vitamin B-6-magnesium treatment for autism: the current status of the
research
SO MAGNESIUM RESEARCH
LA English
DT Letter
ID CHILDREN; DISORDER
C1 [Murza, Kimberly A.; Pavelko, Stacey L.; Malani, Melissa D.; Nye, Chad] Univ Cent Florida, Ctr Autism & Related Disabil, Orlando, FL 32826 USA.
RP Nye, C (reprint author), Univ Cent Florida, Ctr Autism & Related Disabil, 12001 Sci Dr,Suite 145, Orlando, FL 32826 USA.
EM cnye@mail.ucf.edu
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NR 11
TC 2
Z9 2
PU JOHN LIBBEY EUROTEXT LTD
PI MONTROUGE
PA 127 AVE DE LA REPUBLIQUE, 92120 MONTROUGE, FRANCE
SN 0953-1424
J9 MAGNESIUM RES
JI Magnes. Res.
PD JUN
PY 2010
VL 23
IS 2
BP 115
EP 117
PG 3
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA 618LN
UT WOS:000279356100007
PM 20562088
ER
PT J
AU Murray, AL
AF Murray, A. Louise
TI Can the existence of highly accessible concrete representations explain
savant skills? Some insights from synaesthesia
SO MEDICAL HYPOTHESES
LA English
DT Article
ID IDIOTS-SAVANTS; VISUAL-IMAGERY; CALENDAR CALCULATORS; MENTAL-IMAGERY;
SYNESTHESIA; PERCEPTION; AUTISM; MEMORY; INFORMATION; BRAIN
AB The present review argues that the reification of abstract concepts provides a psychological mediating mechanism for calendar and lightning calculation and possibly even all savant skills. The argument, which draws heavily on the synaesthesia literature has two main strands. First, there is anecdotal evidence for the presence and utilisation of highly accessible concrete representations of abstract concepts in savants. Second, synaesthetes who possess these structures experience cognitive benefits in the same domain. The present review concludes that the putative mechanism discussed here is plausible and has some empirical support, however, is in need of further testing. A number of ways in which to proceed in this task are suggested. (C) 2010 Elsevier Ltd. All rights reserved.
C1 Univ Edinburgh, Dept Psychol, Edinburgh EH8 9JZ, Midlothian, Scotland.
RP Murray, AL (reprint author), Univ Edinburgh, Dept Psychol, 7 George Sq, Edinburgh EH8 9JZ, Midlothian, Scotland.
EM s0785823@sms.ed.ac.uk
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NR 78
TC 8
Z9 9
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0306-9877
J9 MED HYPOTHESES
JI Med. Hypotheses
PD JUN
PY 2010
VL 74
IS 6
BP 1006
EP 1012
DI 10.1016/j.mehy.2010.01.014
PG 7
WC Medicine, Research & Experimental
SC Research & Experimental Medicine
GA 598UI
UT WOS:000277863900012
PM 20149553
ER
PT J
AU Elia, J
Gai, X
Xie, HM
Perin, JC
Geiger, E
Glessner, JT
D'arcy, M
Deberardinis, R
Frackelton, E
Kim, C
Lantieri, F
Muganga, BM
Wang, L
Takeda, T
Rappaport, EF
Grant, SFA
Berrettini, W
Devoto, M
Shaikh, TH
Hakonarson, H
White, PS
AF Elia, J.
Gai, X.
Xie, H. M.
Perin, J. C.
Geiger, E.
Glessner, J. T.
D'arcy, M.
deBerardinis, R.
Frackelton, E.
Kim, C.
Lantieri, F.
Muganga, B. M.
Wang, L.
Takeda, T.
Rappaport, E. F.
Grant, S. F. A.
Berrettini, W.
Devoto, M.
Shaikh, T. H.
Hakonarson, H.
White, P. S.
TI Rare structural variants found in attention-deficit hyperactivity
disorder are preferentially associated with neurodevelopmental genes
SO MOLECULAR PSYCHIATRY
LA English
DT Article
DE CNV; ADHD; GRM5; GRM7; PTPRD; autism; schizophrenia
ID LONG-TERM POTENTIATION; RESTLESS-LEGS-SYNDROME; COPY-NUMBER VARIATION;
RECEPTOR-TYPE-DELTA; REPORT SCALE ASRS; DEFICIT/HYPERACTIVITY DISORDER;
REPRESENTATIVE SAMPLE; SCHIZOPHRENIA; ADHD; CHILDREN
AB Attention-deficit/hyperactivity disorder (ADHD) is a common and highly heritable disorder, but specific genetic factors underlying risk remain elusive. To assess the role of structural variation in ADHD, we identified 222 inherited copy number variations (CNVs) within 335 ADHD patients and their parents that were not detected in 2026 unrelated healthy individuals. Although no excess CNVs, either deletions or duplications, were found in the ADHD cohort relative to controls, the inherited rare CNV-associated gene set was significantly enriched for genes reported as candidates in studies of autism, schizophrenia and Tourette syndrome, including A2BP1, AUTS2, CNTNAP2 and IMMP2L. The ADHD CNV gene set was also significantly enriched for genes known to be important for psychological and neurological functions, including learning, behavior, synaptic transmission and central nervous system development. Four independent deletions were located within the protein tyrosine phosphatase gene, PTPRD, recently implicated as a candidate gene for restless legs syndrome, which frequently presents with ADHD. A deletion within the glutamate receptor gene, GRM5, was found in an affected parent and all three affected offspring whose ADHD phenotypes closely resembled those of the GRM5 null mouse. Together, these results suggest that rare inherited structural variations play an important role in ADHD development and indicate a set of putative candidate genes for further study in the etiology of ADHD. Molecular Psychiatry (2010) 15, 637-646; doi: 10.1038/mp.2009.57; published online 23 June 2009
C1 [Hakonarson, H.] Childrens Hosp Philadelphia, Div Pulm Med, Philadelphia, PA 19104 USA.
[Elia, J.; deBerardinis, R.; Takeda, T.] Childrens Hosp Philadelphia, Dept Child & Adolescent Psychiat, Philadelphia, PA 19104 USA.
[Elia, J.; Berrettini, W.] Univ Penn, Sch Med, Dept Psychiat, Philadelphia, PA 19104 USA.
[Gai, X.; Xie, H. M.; Perin, J. C.; D'arcy, M.; Muganga, B. M.; Wang, L.; White, P. S.] Childrens Hosp Philadelphia, Ctr Biomed Informat, Philadelphia, PA 19104 USA.
[Geiger, E.; Lantieri, F.; Grant, S. F. A.; Devoto, M.; Shaikh, T. H.] Childrens Hosp Philadelphia, Div Genet, Philadelphia, PA 19104 USA.
[Rappaport, E. F.] Childrens Hosp Philadelphia, Joseph Stokes Jr Res Inst, Philadelphia, PA 19104 USA.
[Grant, S. F. A.; Devoto, M.; Shaikh, T. H.; Hakonarson, H.; White, P. S.] Univ Penn, Sch Med, Dept Pediat, Philadelphia, PA 19104 USA.
[Devoto, M.] Univ Penn, Sch Med, Dept Biostat & Epidemiol, Philadelphia, PA 19104 USA.
[Devoto, M.] Univ Roma La Sapienza, Dipartimento Med Sperimentale, Rome, Italy.
[Glessner, J. T.; Frackelton, E.; Kim, C.; Grant, S. F. A.; Hakonarson, H.] Childrens Hosp Philadelphia, Ctr Appl Genom, Philadelphia, PA 19104 USA.
[White, P. S.] Childrens Hosp Philadelphia, Div Oncol, Philadelphia, PA 19104 USA.
RP Hakonarson, H (reprint author), Childrens Hosp Philadelphia, Div Pulm Med, 34th St & Civ Ctr Blvd,Rm 1216E ARC, Philadelphia, PA 19104 USA.
EM hakonarson@chop.edu; white@genome.chop.edu
RI Gai, Xiaowu/G-4065-2010
FU National Institutes of Health [K23MH066275, GM081519, P30HD026979];
University of Pennsylvania [UL1-RR-024134]; Pennsylvania Department of
Health [SAP 4100037707]; Cotswold Foundation; Children's Hospital of
Philadelphia
FX The Children's Hospital of Philadelphia Institutional Review Board has
approved this study. This work was supported in part by National
Institutes of Health Grants K23MH066275 (JE), GM081519 (THS), and
P30HD026979 (MD and XG); University of Pennsylvania Grant UL1-RR-024134
(JE); Pennsylvania Department of Health Grant SAP 4100037707 (PSW); and
a Developmental Research Award from the Cotswold Foundation (SG and HH).
All genome-wide genotyping was funded by an Institutional Development
Award from the Children's Hospital of Philadelphia (HH). We thank all
the participating individuals and families for making this study
possible.
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NR 54
TC 168
Z9 170
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1359-4184
J9 MOL PSYCHIATR
JI Mol. Psychiatr.
PD JUN
PY 2010
VL 15
IS 6
BP 637
EP 646
DI 10.1038/mp.2009.57
PG 10
WC Biochemistry & Molecular Biology; Neurosciences; Psychiatry
SC Biochemistry & Molecular Biology; Neurosciences & Neurology; Psychiatry
GA 599DZ
UT WOS:000277891800007
PM 19546859
ER
PT J
AU State, MW
AF State, Matthew W.
TI Another piece of the autism puzzle
SO NATURE GENETICS
LA English
DT Editorial Material
ID FRAGILE-X-SYNDROME; MENTAL-RETARDATION; NEUROLIGINS; MUTATIONS; FAMILY;
NLGN4; MODEL; GENE; MICE
C1 [State, Matthew W.] Yale Univ, Sch Med, Program Neurogenet, New Haven, CT 06520 USA.
[State, Matthew W.] Yale Univ, Sch Med, Dept Child Psychiat, New Haven, CT USA.
[State, Matthew W.] Yale Univ, Sch Med, Dept Psychiat, New Haven, CT USA.
[State, Matthew W.] Yale Univ, Sch Med, Dept Genet, New Haven, CT 06510 USA.
RP State, MW (reprint author), Yale Univ, Sch Med, Program Neurogenet, New Haven, CT 06520 USA.
EM matthew.state@yale.edu
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NR 15
TC 8
Z9 8
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 1061-4036
J9 NAT GENET
JI Nature Genet.
PD JUN
PY 2010
VL 42
IS 6
BP 478
EP 479
PG 3
WC Genetics & Heredity
SC Genetics & Heredity
GA 601RN
UT WOS:000278081500008
PM 20502490
ER
PT J
AU Berkel, S
Marshall, CR
Weiss, B
Howe, J
Roeth, R
Moog, U
Endris, V
Roberts, W
Szatmari, P
Pinto, D
Bonin, M
Riess, A
Engels, H
Sprengel, R
Scherer, SW
Rappold, GA
AF Berkel, Simone
Marshall, Christian R.
Weiss, Birgit
Howe, Jennifer
Roeth, Ralph
Moog, Ute
Endris, Volker
Roberts, Wendy
Szatmari, Peter
Pinto, Dalila
Bonin, Michael
Riess, Angelika
Engels, Hartmut
Sprengel, Rolf
Scherer, Stephen W.
Rappold, Gudrun A.
TI Mutations in the SHANK2 synaptic scaffolding gene in autism spectrum
disorder and mental retardation
SO NATURE GENETICS
LA English
DT Article
ID POSTSYNAPTIC DENSITY; PROTEINS
AB Using microarrays, we identified de novo copy number variations in the SHANK2 synaptic scaffolding gene in two unrelated individuals with autism-spectrum disorder (ASD) and mental retardation. DNA sequencing of SHANK2 in 396 individuals with ASD, 184 individuals with mental retardation and 659 unaffected individuals (controls) revealed additional variants that were specific to ASD and mental retardation cases, including a de novo nonsense mutation and seven rare inherited changes. Our findings further link common genes between ASD and intellectual disability.
C1 [Berkel, Simone; Weiss, Birgit; Roeth, Ralph; Endris, Volker; Rappold, Gudrun A.] Univ Heidelberg, Dept Human Mol Genet, Heidelberg, Germany.
[Marshall, Christian R.; Howe, Jennifer; Pinto, Dalila; Scherer, Stephen W.] Univ Toronto, Hosp Sick Children, Ctr Appl Genom, Toronto, ON M5S 1A1, Canada.
[Moog, Ute] Univ Heidelberg, Dept Human Genet, Heidelberg, Germany.
[Roberts, Wendy] Univ Toronto, Hosp Sick Children, Autism Res Unit, Toronto, ON M5G 1X8, Canada.
[Szatmari, Peter] McMaster Univ, Dept Psychiat & Behav Neurosci, Offord Ctr Child Studies, Hamilton, ON, Canada.
[Bonin, Michael; Riess, Angelika] Univ Tubingen, Inst Human Genet, Dept Med Genet, Tubingen, Germany.
[Engels, Hartmut] Univ Bonn, Inst Human Genet, D-5300 Bonn, Germany.
[Sprengel, Rolf] Univ Heidelberg, Max Planck Inst Med Res MPI, Heidelberg, Germany.
[Scherer, Stephen W.] Univ Toronto, Dept Mol Genet, Toronto, ON M5S 1A1, Canada.
RP Rappold, GA (reprint author), Univ Heidelberg, Dept Human Mol Genet, Heidelberg, Germany.
EM gudrun_rappold@med.uni-heidelberg.de
RI Howe, Jennifer/I-9013-2012; Scherer, Stephen /B-3785-2013
OI Scherer, Stephen /0000-0002-8326-1999
FU international Autism Genome Project; Autism Speaks; German Mental
Retardation Network (MRNET); Federal Ministry of Education and Research,
Germany; Deutsche Forschungsgesellschaft (DFG) [SFB488]; Medical Faculty
of Heidelberg; CellNetworks-Cluster of Excellence [EXC81]; Centre for
Applied Genomics, Genome Canada; Ontario Genomics Institute; Canadian
Institutes for Health Research (CIHR); Canadian Institute for Advanced
Research (CIFAR); McLaughlin Centre; Canada Foundation for Innovation;
Ontario Ministry of Research and Innovation; Hospital for Sick Children
Foundation
FX We gratefully thank E. Fenner, M. Fritsche and S. Peykov for sequencing
and technical support, and we thank all the affected individuals'
families for their cooperation. We thank A. Fiebig, A. Franke and S.
Schreiber at POPGEN (University of Kiel, Kiel, Germany) and A. Stewart,
R. McPherson and R. Roberts of the University of Ottawa Heart Institute
(University of Ottawa, Ottawa, Canada) for generously providing
population control microarray data. The international Autism Genome
Project and Autism Speaks is also gratefully acknowledged for support.
Funding was provided by the German Mental Retardation Network (MRNET),
supported by the Federal Ministry of Education and Research, Germany, by
the Deutsche Forschungsgesellschaft (DFG; SFB488) and the Medical
Faculty of Heidelberg. S. B. was funded by a fellowship of
CellNetworks-Cluster of Excellence (EXC81) and is a member of Hartmut
Hoffmann-Berling International Graduate School of Molecular and Cellular
Biology (HBIGS). S. W. S. is supported by The Centre for Applied
Genomics, Genome Canada and Ontario Genomics Institute, the Canadian
Institutes for Health Research (CIHR), the Canadian Institute for
Advanced Research (CIFAR), the McLaughlin Centre, the Canada Foundation
for Innovation, the Ontario Ministry of Research and Innovation and the
Hospital for Sick Children Foundation. S.W.S. holds the
GlaxoSmithKline-CIHR Chair in Genetics and Genomics at the University of
Toronto and the Hospital for Sick Children. G.A.R. is a member of
CellNetworks-Cluster of Excellence (EXC81). Dedicated to Mrs. Elisabeth
Berkel.
CR Abrahams BS, 2008, NAT REV GENET, V9, P341, DOI 10.1038/nrg2346
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Tarpey PS, 2009, NAT GENET, V41, P535, DOI 10.1038/ng.367
Weiss LA, 2008, NEW ENGL J MED, V358, P667, DOI 10.1056/NEJMoa075974
NR 15
TC 173
Z9 178
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 1061-4036
J9 NAT GENET
JI Nature Genet.
PD JUN
PY 2010
VL 42
IS 6
BP 489
EP 491
DI 10.1038/ng.589
PG 3
WC Genetics & Heredity
SC Genetics & Heredity
GA 601RN
UT WOS:000278081500011
PM 20473310
ER
PT J
AU Welch, MG
Anwar, M
Chang, CY
Gross, KJ
Ruggiero, DA
Tamir, H
Gershon, MD
AF Welch, Martha G.
Anwar, Muhammad
Chang, Christine Y.
Gross, Kara J.
Ruggiero, David A.
Tamir, Hadassah
Gershon, Michael D.
TI Combined administration of secretin and oxytocin inhibits chronic
colitis and associated activation of forebrain neurons
SO NEUROGASTROENTEROLOGY AND MOTILITY
LA English
DT Article
DE autism; gut-brain signaling; inflammatory bowel disease;
interferon-gamma (IFN gamma); neuropeptides; tumor necrosis factor-alpha
(TNF alpha)
ID VASOACTIVE-INTESTINAL-PEPTIDE; INFLAMMATORY-BOWEL-DISEASE; TNBS-INDUCED
COLITIS; AUTISTIC DISORDER; DENDRITIC CELLS; BREAST-MILK; RECEPTOR; RAT;
EXPRESSION; BRAIN
AB Background
The pathogenesis of inflammatory bowel disease is unknown; however, the disorder is aggravated by psychological stress and is itself psychologically stressful. Chronic intestinal inflammation, moreover, has been reported to activate forebrain neurons. We tested the hypotheses that the chronically inflamed bowel signals to the brain through the vagi and that administration of a combination of secretin (S) and oxytocin (OT) inhibits this signaling.
Methods
Three daily enemas containing 2,4,6-trinitrobenzene sulfonic acid (TNBS), which were given to rats produced chronic colitis and ongoing activation of Fos in brain neurons.
Key Results
Fos was induced in neurons in the paraventricular nucleus of the hypothalamus, basolateral amygdala, central amygdala, and piriform cortex. Subdiaphragmatic vagotomy failed to inhibit this activation of Fos, suggesting that colitis activates forebrain neurons independently of the vagi. When administered intravenously, but not when given intracerebroventricularly, in doses that were individually ineffective, combined S/OT prevented colitis-associated activation of central neurons. Strikingly, S/OT decreased inflammatory infiltrates into the colon and colonic expression of tumor necrosis factor-alpha and interferon-gamma.
Conclusions & Inferences
These observations suggest that chronic colonic inflammation is ameliorated by the systemic administration of S/OT, which probably explains the parallel ability of systemic S/OT to inhibit the colitis-associated activation of forebrain neurons.
It is possible that S and OT, which are endogenous to the colon, might normally combine to restrict the severity of colonic inflammatory responses and that advantage might be taken of this system to develop novel means of treating inflammation-associated intestinal disorders.
C1 [Welch, Martha G.; Anwar, Muhammad; Ruggiero, David A.; Tamir, Hadassah] Columbia Univ Coll Phys & Surg, Dept Psychiat, New York, NY 10032 USA.
[Welch, Martha G.; Chang, Christine Y.; Gross, Kara J.; Ruggiero, David A.; Tamir, Hadassah; Gershon, Michael D.] Columbia Univ Coll Phys & Surg, Dept Pathol & Cell Biol, New York, NY 10032 USA.
[Gross, Kara J.] Columbia Univ Coll Phys & Surg, Dept Pediat, New York, NY 10032 USA.
RP Welch, MG (reprint author), New York State Psychiat Inst & Hosp, 1051 Riverside Dr,Unit 40, New York, NY 10032 USA.
EM mgw13@columbia.edu
FU Einhorn Family Charitable Trust [15665]
FX We would like to acknowledge the contributions of Robert Ludwig, T.
Bramwell Welch-Horan, Nargis Anwar, Lawrence McGill, D. Glen Esplin,
Sara Glickstein, Jason Keune and Farrukh Jafri. Funding Columbia Grant #
15665, Einhorn Family Charitable Trust, F. Fairman. Competing interests:
the authors have no competing interests.
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NR 79
TC 7
Z9 7
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 1350-1925
J9 NEUROGASTROENT MOTIL
JI Neurogastroenterol. Motil.
PD JUN
PY 2010
VL 22
IS 6
BP 654
EP +
DI 10.1111/j.1365-2982.2010.01477.x
PG 12
WC Gastroenterology & Hepatology; Clinical Neurology; Neurosciences
SC Gastroenterology & Hepatology; Neurosciences & Neurology
GA 591UB
UT WOS:000277329200014
PM 20210978
ER
PT J
AU Riby, DM
Back, E
AF Riby, Deborah M.
Back, Elisa
TI Can individuals with Williams syndrome interpret mental states from
moving faces?
SO NEUROPSYCHOLOGIA
LA English
DT Article
DE Williams syndrome; Facial expression; Mental states; Social cognition
ID EXPRESSION RECOGNITION; IMPAIRED RECOGNITION; FACIAL EXPRESSIONS;
GENETIC INFLUENCES; ASPERGER-SYNDROME; NORMAL ADULTS; AUTISM; AMYGDALA;
PERCEPTION; LANGUAGE
AB The Williams syndrome (WS) social phenotype is characterised by a high level of social engagement, heightened empathy and prolonged attention to people's faces. These behaviours appear in contradiction to research reporting problems recognising and interpreting basic emotions and more complex mental states from other people. The current task involved dynamic (moving) face stimuli of an actor depicting complex mental states (e.g., worried, disinterested). Cues from the eye and mouth regions were systematically frozen and kept neutrally expressive to help identify the source of mental state information in typical development and WS. Eighteen individuals with WS (aged 8-23 years) and matched groups of typically developing participants were most accurate inferring mental states from whole dynamic faces. In this condition individuals with WS performed at a level predicted by chronological age. When face parts (eyes or mouth) were frozen and neutrally expressive, individuals with WS showed the greatest decrement in performance when the eye region was uninformative. We propose that using moving whole face stimuli individuals with WS can infer mental states and the eye region plays a particularly important role in performance. (C) 2010 Elsevier Ltd. All rights reserved.
C1 [Riby, Deborah M.] Newcastle Univ, Sch Psychol, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England.
[Back, Elisa] Kingston Univ London, Psychol Res Unit, London, England.
RP Riby, DM (reprint author), Newcastle Univ, Sch Psychol, Ridley Bldg,Framlington Pl, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England.
EM D.M.Riby@ncl.ac.uk
FU Williams syndrome Foundation, UK
FX This work was partly supported by funds from the Williams syndrome
Foundation, UK, to D Riby. We would like to thank Adam Combie for
helping with data collection for the participants with Williams syndrome
and all individuals who took part in the research.
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NR 56
TC 6
Z9 6
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0028-3932
J9 NEUROPSYCHOLOGIA
JI Neuropsychologia
PD JUN
PY 2010
VL 48
IS 7
BP 1914
EP 1922
DI 10.1016/j.neuropsychologia.2010.03.010
PG 9
WC Behavioral Sciences; Neurosciences; Psychology, Experimental
SC Behavioral Sciences; Neurosciences & Neurology; Psychology
GA 613ZD
UT WOS:000279023100005
PM 20227428
ER
PT J
AU Chanraud, S
Zahr, N
Sullivan, EV
Pfefferbaum, A
AF Chanraud, Sandra
Zahr, Natalie
Sullivan, Edith V.
Pfefferbaum, Adolf
TI MR Diffusion Tensor Imaging: A Window into White Matter Integrity of the
Working Brain
SO NEUROPSYCHOLOGY REVIEW
LA English
DT Review
DE Diffusion tensor imaging; White matter; Cognition; Psychiatric and
neurological diseases
ID NORMAL-APPEARING WHITE; AUTISM SPECTRUM DISORDERS; QUANTITATIVE FIBER
TRACKING; MILD COGNITIVE IMPAIRMENT; ADULT AGE-DIFFERENCES;
CENTRAL-NERVOUS-SYSTEM; CORPUS-CALLOSUM; ALZHEIMERS-DISEASE; IN-VIVO;
MULTIPLE-SCLEROSIS
AB As Norman Geschwind asserted in 1965, syndromes resulting from white matter lesions could produce deficits in higher-order functions and "disconnexion" or the interruption of connection between gray matter regions could be as disruptive as trauma to those regions per se. The advent of in vivo diffusion tensor imaging, which allows quantitative characterization of white matter fiber integrity in health and disease, has served to strengthen Geschwind's proposal. Here we present an overview of the principles of diffusion tensor imaging (DTI) and its contribution to progress in our current understanding of normal and pathological brain function.
C1 [Chanraud, Sandra; Zahr, Natalie; Sullivan, Edith V.; Pfefferbaum, Adolf] Stanford Univ, Sch Med MC5723, Dept Psychiat & Behav Sci, Stanford, CA 94305 USA.
[Chanraud, Sandra; Zahr, Natalie; Pfefferbaum, Adolf] SRI Int, Neurosci Program, Menlo Pk, CA 94025 USA.
RP Sullivan, EV (reprint author), Stanford Univ, Sch Med MC5723, Dept Psychiat & Behav Sci, 401 Quarry Rd, Stanford, CA 94305 USA.
EM edie@stanford.edu
FU NIAAA [AA012388, AA010723, AA017168, AA017923]; NIA [AG019717]
FX Support for this work was obtained from NIAAA grants AA012388, AA010723,
AA017168, AA017923 and NIA grant AG019717.
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PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1040-7308
J9 NEUROPSYCHOL REV
JI Neuropsychol. Rev.
PD JUN
PY 2010
VL 20
IS 2
SI SI
BP 209
EP 225
DI 10.1007/s11065-010-9129-7
PG 17
WC Psychology, Clinical; Neurosciences
SC Psychology; Neurosciences & Neurology
GA 607AK
UT WOS:000278470400008
PM 20422451
ER
PT J
AU Munesue, T
Yokoyama, S
Nakamura, K
Anitha, A
Yamada, K
Hayashi, K
Asaka, T
Liu, HX
Jin, D
Koizumi, K
Islam, MS
Huang, JJ
Ma, WJ
Kim, UH
Kim, SJ
Park, K
Kim, D
Kikuchi, M
Ono, Y
Nakatani, H
Suda, S
Miyachi, T
Hirai, H
Salmina, A
Pichugina, YA
Soumarokov, AA
Takei, N
Mori, N
Tsujii, M
Sugiyama, T
Yagi, K
Yamagishi, M
Sasaki, T
Yamasue, H
Kato, N
Hashimoto, R
Taniike, M
Hayashi, Y
Hamada, J
Suzuki, S
Ooi, A
Noda, M
Kamiyama, Y
Kido, MA
Lopatina, O
Hashii, M
Amina, S
Malavasi, F
Huang, EJ
Zhang, JS
Shimizu, N
Yoshikawa, T
Matsushima, A
Minabe, Y
Higashida, H
AF Munesue, Toshio
Yokoyama, Shigeru
Nakamura, Kazuhiko
Anitha, Ayyappan
Yamada, Kazuo
Hayashi, Kenshi
Asaka, Tomoya
Liu, Hong-Xiang
Jin, Duo
Koizumi, Keita
Islam, Mohammad Saharul
Huang, Jian-Jun
Ma, Wen-Jie
Kim, Uh-Hyun
Kim, Sun-Jun
Park, Keunwan
Kim, Dongsup
Kikuchi, Mitsuru
Ono, Yasuki
Nakatani, Hideo
Suda, Shiro
Miyachi, Taishi
Hirai, Hirokazu
Salmina, Alla
Pichugina, Yu A.
Soumarokov, Andrei A.
Takei, Nori
Mori, Norio
Tsujii, Masatsugu
Sugiyama, Toshiro
Yagi, Kunimasa
Yamagishi, Masakazu
Sasaki, Tsukasa
Yamasue, Hidenori
Kato, Nobumasa
Hashimoto, Ryota
Taniike, Masako
Hayashi, Yutaka
Hamada, Junichiro
Suzuki, Shioto
Ooi, Akishi
Noda, Mami
Kamiyama, Yuko
Kido, Mizuho A.
Lopatina, Olga
Hashii, Minako
Amina, Sarwat
Malavasi, Fabio
Huang, Eric J.
Zhang, Jiasheng
Shimizu, Nobuaki
Yoshikawa, Takeo
Matsushima, Akihiro
Minabe, Yoshio
Higashida, Haruhiro
TI Two genetic variants of CD38 in subjects with autism spectrum disorder
and controls
SO NEUROSCIENCE RESEARCH
LA English
DT Article
DE CD38; Oxytocin; Mutation; Polymorphism; Autism; High-functioning autism
ID CYCLIC ADP-RIBOSE; HIGH-FUNCTIONING AUTISM; DIAGNOSTIC INTERVIEW;
SOCIAL-BEHAVIOR; BIPOLAR DISORDER; OXYTOCIN; ASSOCIATION; PREVALENCE;
POPULATION; HUMANS
AB The neurobiological basis of autism spectrum disorder (ASD) remains poorly understood. Given the role of CD38 in social recognition through oxytocin (OT) release, we hypothesized that CD38 may play a role in the etiology of ASD. Here, we first examined the immunohistochemical expression of CD38 in the hypothalamus of post-mortem brains of non-ASD subjects and found that CD38 was colocalized with OT in secretory neurons. In studies of the association between CD38 and autism, we analyzed 10 single nucleotide polymorphisms (SNPs) and mutations of CD38 by re-sequencing DNAs mainly from a case-control study in Japan, and Caucasian cases mainly recruited to the Autism Genetic Resource Exchange (AGRE). The SNPs of CD38, rs6449197 (p<0.040) and rs3796863 (p<0.005) showed significant associations with a subset of ASD (IQ>70; designated as high-functioning autism (HFA)) in the U.S. 104 AGRE family trios, but not with Japanese 188 HFA subjects. A mutation that caused tryptophan to replace arginine at amino acid residue 140 (R140W; (rs1800561, 4693C>T)) was found in 0.6-4.6% of the Japanese population and was associated with ASD in the smaller case-control study. The SNP was clustered in pedigrees in which the fathers and brothers of T-allele-carrier probands had ASD or ASD traits. In this cohort OT plasma levels were lower in subjects with the T allele than in those without. One proband with the T allele who was taking nasal OT spray showed relief of symptoms. The two variant CD38 poloymorphysms tested may be of interest with regard of the pathophysiology of ASD. (C) 2010 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.
C1 [Yokoyama, Shigeru; Hayashi, Kenshi; Liu, Hong-Xiang; Jin, Duo; Koizumi, Keita; Islam, Mohammad Saharul; Huang, Jian-Jun; Ma, Wen-Jie; Pichugina, Yu A.; Lopatina, Olga; Hashii, Minako; Amina, Sarwat; Higashida, Haruhiro] Kanazawa Univ, Grad Sch Med, Dept Biophys Genet, Kanazawa, Ishikawa 9208640, Japan.
[Munesue, Toshio; Yokoyama, Shigeru; Liu, Hong-Xiang; Jin, Duo; Koizumi, Keita; Islam, Mohammad Saharul; Huang, Jian-Jun; Ma, Wen-Jie; Hirai, Hirokazu; Sugiyama, Toshiro; Lopatina, Olga; Amina, Sarwat; Minabe, Yoshio; Higashida, Haruhiro] Kanazawa Univ, 21st Century Ctr Excellence COE, Program Innovat Brain Sci Dev Learning & Memory, Kanazawa, Ishikawa 9208640, Japan.
[Munesue, Toshio; Koizumi, Keita; Minabe, Yoshio; Higashida, Haruhiro] Kanazawa Univ, Ctr Child Mental Dev, Osaka Hamamatsu Kanazawa Univ Joint Res Ctr, Kanazawa, Ishikawa 9208640, Japan.
[Munesue, Toshio; Kikuchi, Mitsuru] Kanazawa Univ Hosp, Dept Child Psychiat, Kanazawa, Ishikawa 9208641, Japan.
[Hayashi, Kenshi] Kanazawa Univ Hosp, Dept Clin Lab, Kanazawa, Ishikawa 9208641, Japan.
[Munesue, Toshio; Kikuchi, Mitsuru; Ono, Yasuki; Nakatani, Hideo; Minabe, Yoshio] Kanazawa Univ, Grad Sch Med, Dept Psychiat & Neurobiol, Kanazawa, Ishikawa 9208640, Japan.
[Hayashi, Kenshi; Yagi, Kunimasa; Yamagishi, Masakazu] Kanazawa Univ, Grad Sch Med, Dept Internal Med, Kanazawa, Ishikawa 9208640, Japan.
[Hayashi, Yutaka; Hamada, Junichiro] Kanazawa Univ, Grad Sch Med, Dept Neurosurg, Kanazawa, Ishikawa 9208640, Japan.
[Suzuki, Shioto; Ooi, Akishi] Kanazawa Univ, Grad Sch Med, Dept Mol & Cellular Pathol, Kanazawa, Ishikawa 9208640, Japan.
[Munesue, Toshio; Yokoyama, Shigeru; Islam, Mohammad Saharul; Ma, Wen-Jie; Yamasue, Hidenori; Kato, Nobumasa; Lopatina, Olga; Hashii, Minako; Higashida, Haruhiro] Core Res Evolut Sci & Technol, Tokyo 1020075, Japan.
[Munesue, Toshio; Koizumi, Keita; Takei, Nori; Mori, Norio; Tsujii, Masatsugu; Hashimoto, Ryota; Taniike, Masako; Minabe, Yoshio; Higashida, Haruhiro] Osaka Kanazawa Hamamatsu Univ, United Grad Sch Child Dev, Osaka 5650871, Japan.
[Nakamura, Kazuhiko; Anitha, Ayyappan; Suda, Shiro; Miyachi, Taishi; Takei, Nori; Mori, Norio] Hamamatsu Univ Sch Med, Dept Psychiat & Neurol, Hamamatsu, Shizuoka 4313192, Japan.
[Yamada, Kazuo; Yoshikawa, Takeo] RIKEN Brain Sci Inst, Lab Mol Psychiat, Saitama 3510198, Japan.
[Asaka, Tomoya; Matsushima, Akihiro] Nanao Natl Hosp, Nanao 9208531, Japan.
[Kim, Uh-Hyun] Chonbuk Natl Univ, Sch Med, Dept Biochem, Jeonju, South Korea.
[Kim, Sun-Jun] Chonbuk Natl Univ, Sch Med, Dept Pediat, Jeonju, South Korea.
[Park, Keunwan; Kim, Dongsup] Korea Adv Inst Sci & Technol, Seoul, South Korea.
[Kikuchi, Mitsuru; Minabe, Yoshio] Hokuriku Innovat Cluster Hlth Sci, Kanazawa, Ishikawa 9208640, Japan.
[Hirai, Hirokazu] Gunma Univ, Grad Sch Med, Dept Neurophysiol, Gunma 3718511, Japan.
[Salmina, Alla; Lopatina, Olga] Krasnoyarsk State Med Univ, Dept Med Chem & Biochem, Krasnoyarsk 660022, Russia.
[Pichugina, Yu A.; Soumarokov, Andrei A.] Krasnoyarsk State Med Univ, Dept Psychiat, Krasnoyarsk 660022, Russia.
[Takei, Nori; Mori, Norio] Hamamatsu Univ, Ctr Child Mental Dev, Osaka Hamamatsu Kanazawa Univ Joint Res Ctr, Hamamatsu, Shizuoka 4313197, Japan.
[Tsujii, Masatsugu] Chukyo Univ, Fac Sociol, Aichi 4700393, Japan.
[Sugiyama, Toshiro] Aichi Childrens Hlth & Med Ctr, Aichi 4748710, Japan.
[Sasaki, Tsukasa] Univ Tokyo, Div Counseling & Support, Off Mental Hlth Support, Tokyo 1130033, Japan.
[Sasaki, Tsukasa; Yamasue, Hidenori; Kato, Nobumasa] Univ Tokyo, Grad Sch Med, Dept Neuropsychiat, Tokyo 1138655, Japan.
[Kato, Nobumasa] Showa Univ, Sch Med, Dept Psychiat, Tokyo 1578577, Japan.
[Hashimoto, Ryota; Taniike, Masako] Osaka Univ, Mol Res Ctr, Osaka Hamamatsu Kanazawa Univ Joint Res Ctr, Osaka 5650871, Japan.
[Noda, Mami; Kamiyama, Yuko] Kyushu Univ, Grad Sch Pharmaceut Sci, Lab Pathophysiol, Fukuoka 8128582, Japan.
[Kido, Mizuho A.] Kyushu Univ, Grad Sch Dent Sci, Dept Oral Anat & Cell Biol, Fukuoka 8128582, Japan.
[Malavasi, Fabio] Univ Turin, Sch Med, Immunogenet Lab, Dept Genet Biol & Biochem, I-10126 Turin, Italy.
[Malavasi, Fabio] Univ Turin, Sch Med, CeRMS, I-10126 Turin, Italy.
[Huang, Eric J.; Zhang, Jiasheng] Univ Calif San Francisco, Dept Pathol, San Francisco, CA 94121 USA.
[Huang, Eric J.; Zhang, Jiasheng] Vet Affair Med Ctr, Pathol Serv, San Francisco, CA 94121 USA.
[Shimizu, Nobuaki] Kanazawa Univ, Inst Nat & Environm Technol, Kanazawa, Ishikawa 9201192, Japan.
RP Higashida, H (reprint author), Kanazawa Univ, Grad Sch Med, Dept Biophys Genet, Kanazawa, Ishikawa 9208640, Japan.
EM haruhiro@med.kanazawa-u.ac.jp
RI Kim, Dongsup/C-1612-2011; Salmina, Alla/L-7977-2013; Lopatina,
Olga/I-9610-2014; Hashimoto, Ryota/P-8572-2014
OI Hashimoto, Ryota/0000-0002-5941-4238
FU Japanese Ministry of Education, Culture, Sports, Science, and
Technology; Fondazione Guido Berlucchi and Compagnia di SanPaolo; Japan
Society for the Promotion of Science
FX This study was supported by grants from the Japanese Ministry of
Education, Culture, Sports, Science, and Technology. We thank Takako
Ohbayashi, Michiko Hoshii, and Shizuka Aikawa for technical assistance.
We thank D.A. Brown for discussion, the AGRE for samples, and are
grateful for fundings from Fondazione Guido Berlucchi and Compagnia di
SanPaolo and the Japan-Russian Bilateral Science Promotion Program of
the Japan Society for the Promotion of Science.
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NR 57
TC 61
Z9 62
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
IRELAND
SN 0168-0102
J9 NEUROSCI RES
JI Neurosci. Res.
PD JUN
PY 2010
VL 67
IS 2
BP 181
EP 191
DI 10.1016/j.neures.2010.03.004
PG 11
WC Neurosciences
SC Neurosciences & Neurology
GA 611FR
UT WOS:000278797800010
PM 20435366
ER
PT J
AU Shaw, W
AF Shaw, William
TI Increased urinary excretion of a 3-(3-hydroxyphenyl)-3-hydroxypropionic
acid (HPHPA), an abnormal phenylalanine metabolite of Clostridia spp. in
the gastrointestinal tract, in urine samples from patients with autism
and schizophrenia
SO NUTRITIONAL NEUROSCIENCE
LA English
DT Article
DE m-tyrosine; 3-hydroxyphenylalanine; metronidazole; enkephalins;
Lactobacillus acidophilus
ID IONIZATION MASS-SPECTROMETRY; COA DEHYDROGENASE-DEFICIENCY; CHLOROGENIC
ACID; LIQUID-CHROMATOGRAPHY; ONSET AUTISM; POLYPHENOLS; CHILDREN;
PHENOLICS; PRODUCTS; CAPACITY
AB A compound identified as 3-(3-hydroxyphenyl)-3-hydroxypropionic acid (HPHPA) was found in higher concentrations in urine samples of children with autism compared to age and sex appropriate controls and in an adult with recurrent diarrhea due to Clostridium difficile infections. The highest value measured in urine samples was 7500 mmol/mol creatinine, a value 300 times the median normal adult value, in a patient with acute schizophrenia during an acute psychotic episode. The psychosis remitted after treatment with oral vancomycin with a concomitant marked decrease in HPHPA. The source of this compound appears to be multiple species of anaerobic bacteria of the Clostridium genus. The significance of this compound is that it is a probable metabolite of m-tyrosine (3-hydroxyphenylalanine), a tyrosine analog which depletes brain catecholamines and causes symptoms of autism (stereotypical behavior, hyperactivity, and hyper-reactivity) in experimental animals.
C1 Great Plains Lab Inc, Lenexa, KS 66214 USA.
RP Shaw, W (reprint author), Great Plains Lab Inc, 11813 W 77th St, Lenexa, KS 66214 USA.
EM williamsha@aol.com
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NR 43
TC 15
Z9 15
PU MANEY PUBLISHING
PI LEEDS
PA STE 1C, JOSEPHS WELL, HANOVER WALK, LEEDS LS3 1AB, W YORKS, ENGLAND
SN 1028-415X
J9 NUTR NEUROSCI
JI Nutr. Neurosci.
PD JUN
PY 2010
VL 13
IS 3
BP 135
EP 143
DI 10.1179/147683010X12611460763968
PG 9
WC Neurosciences; Nutrition & Dietetics
SC Neurosciences & Neurology; Nutrition & Dietetics
GA 588DH
UT WOS:000277046900006
PM 20423563
ER
PT J
AU Jyonouchi, H
Geng, L
Cushing-Ruby, A
Monteiro, IM
AF Jyonouchi, Harumi
Geng, Lee
Cushing-Ruby, Agnes
Monteiro, Iona M.
TI Aberrant responses to TLR agonists in pediatric IBD patients; the
possible association with increased production of Th1/Th17 cytokines in
response to candida, a luminal antigen
SO PEDIATRIC ALLERGY AND IMMUNOLOGY
LA English
DT Article
DE Crohn's disease; ulcerative colitis; toll like receptors; cytokines;
food allergy
ID INFLAMMATORY-BOWEL-DISEASE; RESPIRATORY SYNCYTIAL VIRUS; AUTISM SPECTRUM
DISORDERS; REGULATORY T-CELLS; GASTROINTESTINAL SYMPTOMS; PROSPECTIVE
MULTICENTER; DENDRITIC CELLS; YOUNG-CHILDREN; ACTIVITY INDEX;
POLYMORPHISMS
AB Toll like receptors (TLR) regulate innate immune responses sensing byproducts of intestinal microbiota. We examined responses to TLR agonists in children with inflammatory bowel disease (IBD). Peripheral blood mononuclear cells (PBMC) obtained from children with IBD [Crohn's disease (CD, n = 10), ulcerative colitis (UC, n = 10)], children with non-IgE-mediated food allergy (NFA, n = 20), and controls (n = 15) were tested for their production of proinflammatory and counter-regulatory cytokines with TLR agonists in comparison with their cytokine production against milk protein and candida. IBD patients were all in the inactive state. IBD PBMC produced more IL-6 with all the TLR agonists tested than controls. CD PBMC produced more counter-regulatory cytokines with TLR agonists, while UC PBMC produced more IL-1 beta and IL-10 with TLR 7/8 agonist than controls. Cytokine production by NFA PBMC did not differ from controls. CD but not UC PBMC produced more IFN-gamma and IL-17 with candida. Aberrant responses to TLR agonists may be associated with increase in IFN-gamma/IL-17 production against candida in CD children.
C1 [Jyonouchi, Harumi; Geng, Lee; Cushing-Ruby, Agnes] Univ Med & Dent New Jersey, New Jersey Med Sch, Div Allergy Immunol & Infect Dis, Newark, NJ 07101 USA.
[Monteiro, Iona M.] Univ Med & Dent New Jersey, New Jersey Med Sch, Div Pediat Gastroenterol, Newark, NJ 07101 USA.
RP Jyonouchi, H (reprint author), Univ Med & Dent New Jersey, New Jersey Med Sch, Div Allergy Immunol & Infect Dis, Newark, NJ 07101 USA.
EM jyanouha@umdnj.edu
FU Jonty Foundation, St. Paul, MN
FX This study was partly funded by Jonty Foundation, St. Paul, MN. The
authors would like to thank Dr L. Huguenin for critically reviewing this
manuscript.
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NR 38
TC 9
Z9 10
PU WILEY-BLACKWELL PUBLISHING, INC
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0905-6157
J9 PEDIAT ALLERG IMM-UK
JI Pediatr. Allergy Immunol.
PD JUN
PY 2010
VL 21
IS 4
BP E747
EP E755
DI 10.1111/j.1399-3038.2009.00923.x
PN 2
PG 9
WC Allergy; Immunology; Pediatrics
SC Allergy; Immunology; Pediatrics
GA 703QZ
UT WOS:000285997600014
PM 19725895
ER
PT J
AU Baker, JP
AF Baker, Jeffrey P.
TI Autism in 1959: Joey the Mechanical Boy
SO PEDIATRICS
LA English
DT Editorial Material
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C1 [Baker, Jeffrey P.] Duke Univ, Sch Med, Durham, NC USA.
RP Baker, JP (reprint author), Trent Ctr Bioeth Humanities & Hist Med, Dept Pediat, Box 3040 DUMC, Durham, NC 27710 USA.
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TC 3
Z9 3
PU AMER ACAD PEDIATRICS
PI ELK GROVE VILLAGE
PA 141 NORTH-WEST POINT BLVD,, ELK GROVE VILLAGE, IL 60007-1098 USA
SN 0031-4005
J9 PEDIATRICS
JI Pediatrics
PD JUN
PY 2010
VL 125
IS 6
BP 1101
EP 1103
DI 10.1542/peds.2010-0846
PG 3
WC Pediatrics
SC Pediatrics
GA 604GX
UT WOS:000278268600001
PM 20498171
ER
PT J
AU Hammer, LD
Lessin, HR
AF Hammer, Lawrence D.
Lessin, Herschel R.
TI Policy Statement-Increasing Immunization Coverage
SO PEDIATRICS
LA English
DT Article
DE immunization; vaccines; immunization coverage; increasing immunization
coverage; vaccine financing; vaccine supply; vaccine safety;
immunization information system; reminder-recall; missed opportunities;
risk communication; refusal to vaccinate
ID VACCINATION COVERAGE; UNITED-STATES; CHILDREN; ADOLESCENTS; IMPACT; CARE
AB In 1977, the American Academy of Pediatrics issued a statement calling for universal immunization of all children for whom vaccines are not contraindicated. In 1995, the policy statement "Implementation of the Immunization Policy" was published by the American Academy of Pediatrics, followed in 2003 with publication of the first version of this statement, "Increasing Immunization Coverage." Since 2003, there have continued to be improvements in immunization coverage, with progress toward meeting the goals set forth in Healthy People 2010. Data from the 2007 National Immunization Survey showed that 90% of children 19 to 35 months of age have received recommended doses of each of the following vaccines: inactivated poliovirus (IPV), measles-mumps-rubella (MMR), varicella-zoster virus (VZB), hepatitis B virus (HBV), and Haemophilus influenzae type b (Hib). For diphtheria and tetanus and acellular pertussis (DTaP) vaccine, 84.5% have received the recommended 4 doses by 35 months of age. Nevertheless, the Healthy People 2010 goal of at least 80% coverage for the full series (at least 4 doses of DTaP, 3 doses of IPV, 1 dose of MMR, 3 doses of Hib, 3 doses of HBV, and 1 dose of varicella-zoster virus vaccine) has not yet been met, and immunization coverage of adolescents continues to lag behind the goals set forth in Healthy People 2010. Despite these encouraging data, a vast number of new challenges that threaten continued success toward the goal of universal immunization coverage have emerged. These challenges include an increase in new vaccines and new vaccine combinations as well as a significant number of vaccines currently under development; a dramatic increase in the acquisition cost of vaccines, coupled with a lack of adequate payment to practitioners to buy and administer vaccines; unanticipated manufacturing and delivery problems that have caused significant shortages of various vaccine products; and the rise of a public antivaccination movement that uses the Internet as well as standard media outlets to advance a position, wholly unsupported by any scientific evidence, linking vaccines with various childhood conditions, particularly autism. Much remains to be accomplished by physician organizations; vaccine manufacturers; third-party payers; the media; and local, state, and federal governments to ensure dependable vaccine supply and payments that are sufficient to continue to provide immunizations in public and private settings and to promote effective strategies to combat unjustified misstatements by the antivaccination movement.
Pediatricians should work individually and collectively at the local, state, and national levels to ensure that all children without a valid contraindication receive all childhood immunizations on time. Pediatricians and pediatric organizations, in conjunction with government agencies such as the Centers for Disease Control and Prevention, must communicate effectively with parents to maximize their understanding of the overall safety and efficacy of vaccines. Most parents and children have not experienced many of the vaccine-preventable diseases, and the general public is not well informed about the risks and sequelae of these conditions. A number of recommendations are included for pediatricians, individually and collectively, to support further progress toward the goal of universal immunization coverage of all children for whom vaccines are not contraindicated. Pediatrics 2010; 125: 1295-1304
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NR 26
TC 19
Z9 21
PU AMER ACAD PEDIATRICS
PI ELK GROVE VILLAGE
PA 141 NORTH-WEST POINT BLVD,, ELK GROVE VILLAGE, IL 60007-1098 USA
SN 0031-4005
J9 PEDIATRICS
JI Pediatrics
PD JUN
PY 2010
VL 125
IS 6
BP 1295
EP 1304
DI 10.1542/peds.2010-0743
PG 10
WC Pediatrics
SC Pediatrics
GA 604GX
UT WOS:000278268600024
PM 20513736
ER
PT J
AU Meltzer, LJ
Johnson, C
Crosette, J
Ramos, M
Mindell, JA
AF Meltzer, Lisa J.
Johnson, Courtney
Crosette, Jonathan
Ramos, Mark
Mindell, Jodi A.
TI Prevalence of Diagnosed Sleep Disorders in Pediatric Primary Care
Practices
SO PEDIATRICS
LA English
DT Article
DE sleep disorders; children; adolescents; primary care
ID RESTLESS-LEGS-SYNDROME; SCHOOL-AGED CHILDREN; UNITED-STATES;
ADOLESCENTS; CHILDHOOD; OBESITY; DIFFICULTIES; MEDICATION; EDUCATION;
PATTERNS
AB OBJECTIVES: The primary aim was to determine the prevalence of International Classification of Diseases, Ninth Revision (ICD-9), sleep disorders diagnosed by pediatric providers in a large, primary care network. Secondary aims were to examine demographic variables related to these diagnoses and to examine the frequency of prescriptions for medications potentially used to treat sleep disorders.
METHODS: Electronic medical records were reviewed for 154 957 patients (0-18 years) seen for a well-child visit in 2007. Information collected included ICD-9 sleep diagnoses, demographic variables, comorbid attention-deficit/hyperactivity disorder and autism spectrum disorders, provider type, and medications.
RESULTS: Across all ages, 3.7% of youths had an ICD-9 diagnosis for a sleep disorder. The most-common diagnoses were sleep disorder not otherwise specified, enuresis, and sleep-disordered breathing. Predictors of sleep disorders varied according to developmental age group and included growth parameters, comorbid attention-deficit/hyperactivity disorder or autism spectrum disorder, and provider type. Potential sleep-related medications were prescribed for 6.1% of the sample subjects.
CONCLUSIONS: This study is one of the first to examine comprehensively ICD-9 sleep diagnoses given by primary care providers in a large representative sample of children 0 to 18 years of age. The 3.7% of patients with ICD-9 sleep diagnoses is significantly lower than prevalence rates reported in epidemiological studies, which suggests that primary care providers may be underdiagnosing sleep disorders in children and adolescents. Because sleep disorders are treatable when recognized, the results from this study suggest a significant need for additional education and support for primary care providers in the diagnosis and treatment of pediatric sleep disorders. Pediatrics 2010; 125: e1410-e1418
C1 [Meltzer, Lisa J.; Johnson, Courtney; Mindell, Jodi A.] Childrens Hosp Philadelphia, Div Pulm Med, Philadelphia, PA 19104 USA.
[Crosette, Jonathan; Ramos, Mark] Childrens Hosp Philadelphia, Ctr Biomed Informat, Philadelphia, PA 19104 USA.
[Meltzer, Lisa J.] Univ Penn, Sch Med, Dept Pediat, Philadelphia, PA 19104 USA.
[Johnson, Courtney] Univ Penn, Sch Med, Ctr Sleep & Resp Neurobiol, Philadelphia, PA 19104 USA.
[Mindell, Jodi A.] St Josephs Univ, Dept Psychol, Philadelphia, PA 19131 USA.
RP Meltzer, LJ (reprint author), Childrens Hosp Philadelphia, Div Pulm Med, 3535 Market St,14th Floor, Philadelphia, PA 19104 USA.
EM meltzerl@email.chop.edu
FU National Institutes of Health [K23 MH077662]
FX This study was supported in part by National Institutes of Health grant
K23 MH077662.
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NR 51
TC 23
Z9 23
PU AMER ACAD PEDIATRICS
PI ELK GROVE VILLAGE
PA 141 NORTH-WEST POINT BLVD,, ELK GROVE VILLAGE, IL 60007-1098 USA
SN 0031-4005
EI 1098-4275
J9 PEDIATRICS
JI Pediatrics
PD JUN
PY 2010
VL 125
IS 6
BP E1410
EP E1418
DI 10.1542/peds.2009-2725
PG 9
WC Pediatrics
SC Pediatrics
GA 604GX
UT WOS:000278268600046
PM 20457689
ER
PT J
AU Sawada, A
Ikeda, H
Kimura-Ohba, S
Matsuzawa, S
Awaya, T
Shiotani, Y
Okada, M
Tomiwa, K
AF Sawada, Akiko
Ikeda, Hiroko
Kimura-Ohba, Shihoko
Matsuzawa, Shigeyuki
Awaya, Tomonori
Shiotani, Yuka
Okada, Masako
Tomiwa, Kiyotaka
TI Head growth evaluation in early childhood, from the Japan Children's
Study
SO PEDIATRICS INTERNATIONAL
LA English
DT Article
DE cohort study; early childhood; familial factors; head circumference;
physical growth
ID WILLIAMS-SYNDROME; CIRCUMFERENCE; SIZE; AUTISM; HEIGHT; INFANTS; BIRTH;
TOOL; AGE
AB Background:
Head circumference (HC) trajectories are held to reflect neurological development and the acquirement of intelligence. It is important to assess HC growth accurately because atypical HC growth is an indicator of various developmental disorders. HC growth is determined by both familial and physical factors but, hitherto, no one has considered both factors together. The aim of the present study was thus to investigate the relationship between HC, physical growth, and parental HC.
Methods:
The study group in the Japan Children's Study consisted of 192 healthy full-term Japanese children. HC (maximum occiptofrontal circumference), height and bodyweight were measured at the ages of 4, 9 and 18 months. Multiple regression analysis were conducted predicting the HC from the body measurements and mid-parental HC (defined as the average of standardized paternal and maternal HC).
Results:
Adjusted multiple R2 were 0.336, 0.307 and 0.259, measured at the aforementioned three stages. Bodyweight and mid-parental HC predicted the HC on each occasion (P < 0.01). Bodyweight was more relevant than mid-parental HC.
Conclusions:
HC growth is influenced by physical growth and parental HC; therefore, it is important to consider both physical and familial factors. A formula is herein proposed to assess HC using bodyweight and mid-parental HC.
C1 [Tomiwa, Kiyotaka] Kyoto Univ, Dept Clin Genet & Clin Res, Grad Sch Med, Sakyo Ku, Kyoto 6068501, Japan.
[Ikeda, Hiroko] Natl Epilepsy Ctr Shizuoka, Shizuoka, Japan.
[Sawada, Akiko; Kimura-Ohba, Shihoko; Matsuzawa, Shigeyuki; Awaya, Tomonori; Shiotani, Yuka; Okada, Masako; Tomiwa, Kiyotaka] Japan Sci & Technol Agcy, Japan Childrens Study, Osaka Res Grp, Osaka, Japan.
RP Tomiwa, K (reprint author), Kyoto Univ, Dept Clin Genet & Clin Res, Grad Sch Med, Sakyo Ku, Kyoto 6068501, Japan.
EM tomiwa@pbh.med.kyoto-u.ac.jp
FU Research Institute of Science and Technology for Society (RISTEX) of
Japan Science and Technology Agency (JST)
FX This study was supported by a grant from the Research Institute of
Science and Technology for Society (RISTEX) of Japan Science and
Technology Agency (JST). We gratefully thank the participating families,
Dr T Maeda (Institute of Statistical Mathematics, Japan) for many
helpful suggestions on statistics and Kayo Ohmura, Mie Kawajiri, Junko
Aota, Kyoko Kobayashi, Akemi Takiishi, and Yumi Yoshida for their
assistance.
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NR 24
TC 4
Z9 4
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 1328-8067
J9 PEDIATR INT
JI Pediatr. Int.
PD JUN
PY 2010
VL 52
IS 3
BP 343
EP 346
DI 10.1111/j.1442-200X.2009.03002.x
PG 4
WC Pediatrics
SC Pediatrics
GA 611HH
UT WOS:000278803000017
PM 19912556
ER
PT J
AU Frye, CA
Bloom, MS
Wersinger, S
AF Frye, Cheryl A.
Bloom, Michael S.
Wersinger, Scott
TI Androgens, autism and more
SO PHYSIOLOGY & BEHAVIOR
LA English
DT Editorial Material
C1 [Frye, Cheryl A.; Bloom, Michael S.] SUNY Albany, Dept Environm Hlth Sci, Albany, NY 12222 USA.
[Wersinger, Scott] SUNY Buffalo, Dept Psychol, Buffalo, NY 14260 USA.
RP Frye, CA (reprint author), SUNY Albany, Dept Environm Hlth Sci, Life Sci Room 1058, Albany, NY 12222 USA.
EM fryeca@gmail.com
NR 0
TC 0
Z9 0
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0031-9384
J9 PHYSIOL BEHAV
JI Physiol. Behav.
PD JUN 1
PY 2010
VL 100
IS 3
SI SI
BP 197
EP 198
DI 10.1016/j.physbeh.2010.01.017
PG 2
WC Psychology, Biological; Behavioral Sciences
SC Psychology; Behavioral Sciences
GA 603EW
UT WOS:000278192400001
PM 20097217
ER
PT J
AU Bloom, MS
Houston, AS
Mills, JL
Molloy, CA
Hediger, ML
AF Bloom, Michael S.
Houston, Allison S.
Mills, James L.
Molloy, Cynthia A.
Hediger, Mary L.
TI Finger bone immaturity and 2D:4D ratio measurement error in the
assessment of the hyperandrogenic hypothesis for the etiology of autism
spectrum disorders
SO PHYSIOLOGY & BEHAVIOR
LA English
DT Article
DE Autism spectrum disorder; Digit ratio; Hyperandrogenic hypothesis;
Measurement error
ID 4TH DIGIT RATIO; ETHNIC-DIFFERENCES; RELATIVE LENGTHS; 4TH-DIGIT RATIO;
SEX-DIFFERENCES; 2ND; TESTOSTERONE; 2ND-DIGIT; CHILDREN; MALES
AB Emerging hypotheses suggest a causal role for prenatal androgen exposure in some cases of autism spectrum disorders (ASD). The ratios of the lengths of the bones of the 2nd to the 4th digit (2D:4D) are purported to be markers for prenatal androgen exposure and to be established early in gestation. Elongation of the 4th digit in response to testosterone is said to reduce 2D:4D in males versus females. We examined the ratios of bones from the left hand radiographs of 75 boys and 6 girls 4-8 years of age, diagnosed with ASD, to evaluate digit ratio as a marker for gestational androgen exposure. Contrary to our expectations, girls had reduced 2D:4D compared to boys but the difference was not significant (Cohen's D 0.51-0.66, P > 0.05). The limited sample size for this study and the absence of a referent group precluded providing robust estimates for girls and identifying possible statistical differences between the sexes. Tanner-Whitehouse 3 (TW3) rating of finger bone growth suggested relative immaturity of the 4th relative to the 2nd digits. Positive correlations were detected for 2D:4D ratios, body mass index (r = 0.23, P = 0.039), chronologic age (r = 0.35, P = 0.001), and skeletal age (r = 0.42, P < 0.0001). The TW3 ratings and associations between 2D:4D ratios and indicators of growth suggest that digits develop at different rates. This asynchronous development may produce differences in 2D:4D over time which could lead to erroneous interpretation of androgen exposure in utero among young ASD children. (C) 2010 Elsevier Inc. All rights reserved.
C1 [Bloom, Michael S.] SUNY Albany, Dept Environm Hlth Sci, Rensselaer, NY 12214 USA.
[Houston, Allison S.] SUNY Albany, Dept Epidemiol & Biostat, Rensselaer, NY 12214 USA.
[Mills, James L.; Hediger, Mary L.] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Div Epidemiol Stat & Prevent Res, Bethesda, MD 20892 USA.
[Molloy, Cynthia A.] Cincinnati Childrens Hosp, Div Neurol, Med Ctr, Cincinnati, OH 45229 USA.
RP Bloom, MS (reprint author), Sch Publ Hlth, Dept Environm Hlth Sci, Rm 153,1 Univ Pl, Rensselaer, NY 12144 USA.
EM mbloom@albany.edu
FU Eunice Kennedy Shriver National Institute of Child Health and Human
Development Intramural [Z01 HD008742]; National Institutes of Health
[M01 RR08084]
FX This research was funded by the Eunice Kennedy Shriver National
Institute of Child Health and Human Development Intramural funding
program (Z01 HD008742) and the National Institutes of Health (M01
RR08084). We acknowledge the substantial contributions of Daniel A.
Warren, who measured the radiographs as part of his student internship
at the NICHD, Scott C. Bello, MD, for critical review of this manuscript
at the early stages, and Mark Brasington, who was responsible for all
aspects of data collection at the Cincinnati Children's Hospital Medical
Center.
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NR 32
TC 8
Z9 8
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0031-9384
J9 PHYSIOL BEHAV
JI Physiol. Behav.
PD JUN 1
PY 2010
VL 100
IS 3
SI SI
BP 221
EP 224
DI 10.1016/j.physbeh.2010.01.005
PG 4
WC Psychology, Biological; Behavioral Sciences
SC Psychology; Behavioral Sciences
GA 603EW
UT WOS:000278192400006
PM 20093135
ER
PT J
AU Messer, A
AF Messer, Anne
TI Mini-review: Polybrominated diphenyl ether (PBDE) flame retardants as
potential autism risk factors
SO PHYSIOLOGY & BEHAVIOR
LA English
DT Review
DE Autism; Brominated flame retardants; PBDE; Thyroid hormone
ID MAGNETIC PARTICLE IMMUNOASSAY; THYROID-HORMONE LEVELS; SPRAGUE-DAWLEY
RATS; GENE-EXPRESSION; INBRED STRAINS; 2,2',4,4',5-PENTABROMODIPHENYL
ETHER; NEONATAL EXPOSURE; HEXABROMOCYCLODODECANE HBCD; DEVELOPMENTAL
EXPOSURE; SPONTANEOUS BEHAVIOR
AB Brominated flame retardants, including Polybrominated diphenyl ethers (PBDEs) have been used at increasing levels in home furnishings and electronics over the past 25 years. They have also become widespread environmental pollutants. High PBDE levels have been detected in food, household dust, and indoor air, with subsequent appearance in animal and human tissues. This minireview summarizes studies on the extent to which these compounds can act as potent thyroid hormone mimetics, and emerging studies on long-term neurological effects of acute administration of PBDEs during development. When these data are considered in combination with the extensive literature on stage-dependent effects of thyroid hormone on aspects of brain development that are also implicated in autistic brains, a hypothesis that PBDEs might also serve as autism risk factors emerges. Studies designed to explicitly test this hypothesis will require chronic exposure paradigms, and specific body burden and behavioral monitoring in animal models. Such testing may help to prioritize extensive human epidemiological studies, as well as offer protocols for evaluation of future compounds. (C) 2010 Elsevier Inc. All rights reserved.
C1 [Messer, Anne] NY State Dept Hlth, Wadsworth Ctr, Albany, NY 12208 USA.
[Messer, Anne] SUNY Albany, Dept Biomed Sci, Albany, NY 12208 USA.
RP Messer, A (reprint author), David Axelrod Inst, New Scotland Ave,POB 22002, Albany, NY 12201 USA.
EM messer@wadsworth.org
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NR 81
TC 23
Z9 25
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0031-9384
J9 PHYSIOL BEHAV
JI Physiol. Behav.
PD JUN 1
PY 2010
VL 100
IS 3
SI SI
BP 245
EP 249
DI 10.1016/j.physbeh.2010.01.011
PG 5
WC Psychology, Biological; Behavioral Sciences
SC Psychology; Behavioral Sciences
GA 603EW
UT WOS:000278192400010
PM 20100501
ER
PT J
AU Schaevitz, LR
Moriuchi, JM
Nag, N
Mellot, TJ
Berger-Sweeney, J
AF Schaevitz, Laura R.
Moriuchi, Jennifer M.
Nag, Nupur
Mellot, Tiffany J.
Berger-Sweeney, Joanne
TI Cognitive and social functions and growth factors in a mouse model of
Rett syndrome
SO PHYSIOLOGY & BEHAVIOR
LA English
DT Article
DE Autism; Object recognition; Social approach; Social novelty; IGF-1;
BDNF; NGF
ID MECP2 MUTANT MICE; DIETARY CHOLINE SUPPLEMENTATION; CPG-BINDING
PROTEIN-2; FACTOR-I; CEREBROSPINAL-FLUID; GENE-EXPRESSION; RAT-BRAIN;
NEUROTROPHIC FACTORS; BDNF TRANSCRIPTION; BASAL FOREBRAIN
AB Rett syndrome (RTT) is an autism-spectrum disorder caused by mutations in the X-linked gene encoding methyl-CpG-binding protein 2 (MeCP2). Abnormalities in social behavior, stereotyped movements, and restricted interests are common features in both RTT and classic autism. While mouse models of both RTT and autism exist, social behaviors have not been explored extensively in mouse models of RTT. Here, we report cognitive and social abnormalities in Mecp2(Ilox) null mice, an animal model of RTT. The null mice show severe deficits in short- and long-term object recognition memories, reminiscent of the severe cognitive deficits seen in RTT girls. Social behavior, however, is abnormal in that the null mice spend more time in contact with stranger mice than do wildtype controls. These findings are consistent with reports of increased reciprocal social interaction in RTT girls relative to classic autism. We also report here that the levels of the neurotrophins brain-derived neurotrophic factor (BDNF), insulin-like growth factor-1 (IGF-1), and nerve growth factor (NGF) are decreased in the hippocampus of the null mice, and discuss how this may provide an underlying mechanism for both the cognitive deficits and the increased motivation for social contact observed in the Mecp(Ilox) null mice. These studies support a differential etiology between RTT and autism, particularly with respect to sociability deficits. (C) 2010 Elsevier Inc. All rights reserved.
C1 [Schaevitz, Laura R.; Moriuchi, Jennifer M.; Nag, Nupur; Berger-Sweeney, Joanne] Wellesley Coll, Dept Biol Sci, Wellesley, MA 02481 USA.
[Mellot, Tiffany J.] Boston Univ, Dept Pathol & Lab Med, Sch Med, Boston, MA 02118 USA.
RP Berger-Sweeney, J (reprint author), Wellesley Coll, Dept Biol Sci, Wellesley, MA 02481 USA.
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NR 83
TC 26
Z9 26
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0031-9384
J9 PHYSIOL BEHAV
JI Physiol. Behav.
PD JUN 1
PY 2010
VL 100
IS 3
SI SI
BP 255
EP 263
DI 10.1016/j.physbeh.2009.12.025
PG 9
WC Psychology, Biological; Behavioral Sciences
SC Psychology; Behavioral Sciences
GA 603EW
UT WOS:000278192400012
PM 20045424
ER
PT J
AU Frye, CA
Llaneza, DC
AF Frye, Cheryl A.
Llaneza, Danielle C.
TI Corticosteroid and neurosteroid dysregulation in an animal model of
autism, BTBR mice
SO PHYSIOLOGY & BEHAVIOR
LA English
DT Article
DE Affect; Learning; Memory; Stress; Neurosteroid; Autism spectrum
disorder; Allopregnanolone; Corticosterone
ID VENTRAL TEGMENTAL AREA; PLASMA BETA-ENDORPHIN; PROGESTIN CONCENTRATIONS;
PSYCHOACTIVE MEDICINES; SOCIAL INTERACTIONS; MAJOR DEPRESSION; RAT
HYPOTHALAMUS; SIGMA-RECEPTORS; CORTISOL-LEVELS; INBRED STRAINS
AB Autism spectrum disorders (ASD) are a constellation of neurodevelopmental disorders associated with disruptions in social, cognitive, and/or motor behaviors. ASD are more prevalent among males than females and characterized by aberrant social and language development, and a dysregulation in stress-responding. Levels of progesterone (P(4)) and its metabolite 5 alpha-pregnan-3 alpha-ol-20-one (3 alpha,5 alpha-THP) are higher and more variable in females compared to males. 3 alpha,5 alpha-THP is also a neurosteroid, which can be rapidly produced de novo in the brain, independent of peripheral gland secretion, and can exert homeostatic effects to modulate stress-responding. An inbred mouse strain that has demonstrated an ASD-like behavioral and neuroendocrine phenotype is BTBR T + tf/J (BTBR). BTBR mice have deficits in cognitive and social behaviors and have high circulating levels of the stress hormone, corticosterone. We hypothesized that central 3 alpha,5 alpha-THP levels would be different among BTBR mice compared to mice on a similar background C57BL/6J (C57/J) and 129S1/SvImJ (129S1). Tissues were collected from BTBR, C57/J and 129S1 male mice and levels of corticosterone, P4, and 3 alpha,5 alpha-THP in plasma and in the hypothalamus, midbrain, hippocampus, and cerebellum were measured by radioimmunoassay. Circulating levels of corticosterone, P4, and 3 alpha,5 alpha-THP were significantly higher among BTBR, than C57/J and 129S1, mice. Levels of P4 in the cerebellum were significantly higher than other brain regions among all mouse strains. Levels of 3 alpha,5 alpha-THP in the hypothalamus of BTBR mice were significantly higher compared to C57/J and 12951 mice. These findings suggest that neuroendocrine dysregulation among BTBR mice extends to 3 alpha,5 alpha-THP. (C) 2010 Elsevier Inc. All rights reserved.
C1 [Frye, Cheryl A.; Llaneza, Danielle C.] SUNY Albany, Dept Psychol, Albany, NY 12222 USA.
[Frye, Cheryl A.] SUNY Albany, Dept Biol Sci, Albany, NY 12222 USA.
[Frye, Cheryl A.] SUNY Albany, Ctr Life Sci, Albany, NY 12222 USA.
[Frye, Cheryl A.] SUNY Albany, Neurosci Res Ctr, Albany, NY 12222 USA.
RP Frye, CA (reprint author), SUNY Albany, Dept Psychol, Life Sci Room 1058, Albany, NY 12222 USA.
EM fryeca@gmail.com
FU NIMH [MH06769801]; NSF [IBN0316083]
FX This research was supported by grants from the NIMH (MH06769801), the
NSF (IBN0316083) and an intramural Faculty Research Award Program. We
thank Dr. Jacqueline Crawley and Dr. Jill Silverman, Laboratory of
Behavioral Neuroscience, Intramural Research Program, National Institute
of Mental Health, who provided scientific input and practical
assistance. We also thank the assistance of Dr. Valerie Bolivar and Dr.
Derek Symula at Wadsworth Center. Tissues generated for training
purposes for Dr. Symula provided the basis for this study.
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NR 56
TC 18
Z9 18
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0031-9384
J9 PHYSIOL BEHAV
JI Physiol. Behav.
PD JUN 1
PY 2010
VL 100
IS 3
SI SI
BP 264
EP 267
DI 10.1016/j.physbeh.2010.03.005
PG 4
WC Psychology, Biological; Behavioral Sciences
SC Psychology; Behavioral Sciences
GA 603EW
UT WOS:000278192400013
PM 20298706
ER
PT J
AU Llaneza, DC
DeLuke, SV
Batista, M
Crawley, JN
Christodulu, KV
Frye, CA
AF Llaneza, Danielle C.
DeLuke, Susan V.
Batista, Myra
Crawley, Jacqueline N.
Christodulu, Kristin V.
Frye, Cheryl A.
TI Communication, interventions, and scientific advances in autism: A
commentary
SO PHYSIOLOGY & BEHAVIOR
LA English
DT Editorial Material
DE Autism spectrum disorders; Social; Communication; Language; Gender
differences; Behavior modeling; Picture Exchange Communication System;
Mice; Genetics; BTBR; Center for Autism and Related Disabilities;
Education programs; Translational research
ID HIGH-FUNCTIONING AUTISM; TUBEROUS SCLEROSIS COMPLEX; SOCIAL APPROACH
BEHAVIORS; BTBR-T+TF/J MICE; SPECTRUM DISORDERS; RISK-FACTORS; CANDIDATE
GENES; GENOMIC SCREEN; MOLECULAR-GENETICS; ASPERGERS-DISORDER
AB Autism spectrum disorders (ASD) affect approximately 1 in 150 children across the U.S., and are characterized by abnormal social actions, language difficulties, repetitive or restrictive behaviors, and special interests. ASD include autism (autistic disorder), Asperger Syndrome, and Pervasive Developmental Disorder not otherwise specified (PDD-NOS or atypical autism). High-functioning individuals may communicate with moderate-to-high language skills, although difficulties in social skills may result in communication deficits. Low-functioning individuals may have severe deficiencies in language, resulting in poor communication between the individual and others. Behavioral intervention programs have been developed for ASD, and are frequently adjusted to accommodate specific individual needs. Many of these programs are school-based and aim to support the child in the development of their skills, for use outside the classroom with family and friends. Strides are being made in understanding the factors contributing to the development of ASD, particularly the genetic contributions that may underlie these disorders. Mutant mouse models provide powerful research tools to investigate the genetic factors associated with ASD and its comorbid disorders. In support, the BTBR T+tf/J mouse strain incorporates ASD-like social and communication deficits and high levels of repetitive behaviors. This commentary briefly reviews the reciprocal relationship between observations made during evidence-based behavioral interventions of high- versus low-functioning children with ASD and the accumulating body of research in autism, including animal studies and basic research models. This reciprocity is one of the hallmarks of the scientific method, such that research may inform behavioral treatments, and observations made during treatment may inform subsequent research. (C) 2010 Elsevier Inc. All rights reserved.
C1 [Llaneza, Danielle C.; Frye, Cheryl A.] SUNY Albany, Dept Psychol, Albany, NY 12222 USA.
[DeLuke, Susan V.] Coll St Rose, Dept Literacy & Special Educ, Albany, NY USA.
[Batista, Myra] Kevin G Langan Sch, Ctr Disabil Serv, Albany, NY USA.
[Crawley, Jacqueline N.] NIMH, Intramural Res Program, Lab Behav Neurosci, Bethesda, MD 20892 USA.
[Christodulu, Kristin V.] SUNY Albany, Ctr Autism & Related Disabil, Albany, NY 12222 USA.
[Frye, Cheryl A.] SUNY Albany, Dept Biol, Albany, NY 12222 USA.
[Frye, Cheryl A.] SUNY Albany, Ctr Life Sci, Albany, NY 12222 USA.
RP Frye, CA (reprint author), SUNY Albany, Dept Psychol, Life Sci Room 1058, Albany, NY 12222 USA.
EM cafrye@albany.edu
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2007, MMWR, V56, pSS1
NR 148
TC 6
Z9 6
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0031-9384
J9 PHYSIOL BEHAV
JI Physiol. Behav.
PD JUN 1
PY 2010
VL 100
IS 3
SI SI
BP 268
EP 276
DI 10.1016/j.physbeh.2010.01.003
PG 9
WC Psychology, Biological; Behavioral Sciences
SC Psychology; Behavioral Sciences
GA 603EW
UT WOS:000278192400014
PM 20093134
ER
PT J
AU Fifer, WP
Byrd, DL
Kaku, M
Eigsti, IM
Isler, JR
Grose-Fifer, J
Tarullo, AR
Balsam, PD
AF Fifer, William P.
Byrd, Dana L.
Kaku, Michelle
Eigsti, Inge-Marie
Isler, Joseph R.
Grose-Fifer, Jillian
Tarullo, Amanda R.
Balsam, Peter D.
TI Newborn infants learn during sleep
SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF
AMERICA
LA English
DT Article
DE EEG; eyelid conditioning; neonate
ID AUDITORY EVOKED-POTENTIALS; HEART-RATE; DEATH-SYNDROME; SPEECH SOUNDS;
FULL-TERM; CEREBELLUM; DYSLEXIA; AGE; ABNORMALITIES; MATURATION
AB Newborn infants must rapidly adjust their physiology and behavior to the specific demands of the novel postnatal environment. This adaptation depends, at least in part, on the infant's ability to learn from experiences. We report here that infants exhibit learning even while asleep. Bioelectrical activity from face and scalp electrodes was recorded from neonates during an eye movement conditioning procedure in which a tone was followed by a puff of air to the eye. Sleeping newborns rapidly learned the predictive relationship between the tone and the puff. Additionally, in the latter part of training, these infants exhibited a frontally maximum positive EEG slow wave possibly reflecting memory updating. As newborns spend most of their time sleeping, the ability to learn about external stimuli in the postnatal environment during non-awake states may be crucial for rapid adaptation and infant survival. Furthermore, because eyelid conditioning reflects functional cerebellar circuitry, this method potentially offers a unique approach for early identification of infants at risk for a range of developmental disorders including autism and dyslexia.
C1 [Fifer, William P.; Kaku, Michelle; Tarullo, Amanda R.; Balsam, Peter D.] Columbia Univ, Dept Psychiat, New York, NY 10032 USA.
[Fifer, William P.; Isler, Joseph R.] Columbia Univ, Dept Pediat, New York, NY 10032 USA.
[Fifer, William P.] New York State Psychiat Inst & Hosp, New York, NY 10032 USA.
[Byrd, Dana L.] Univ Florida, Dept Psychol, Gainesville, FL 32611 USA.
[Eigsti, Inge-Marie] Univ Connecticut, Dept Psychol, Storrs, CT 06269 USA.
[Grose-Fifer, Jillian] CUNY John Jay Coll Criminal Justice, Dept Psychol, New York, NY 10019 USA.
[Balsam, Peter D.] Columbia Univ Barnard Coll, Dept Psychol, New York, NY 10027 USA.
RP Fifer, WP (reprint author), Columbia Univ, Dept Psychiat, New York, NY 10032 USA.
EM wpf1@columbia.edu
FU Sackler Institute of Developmental Psychobiology at Columbia University;
National Institutes of Health [R37 HD032774, T32 MH018264, R01 MH068073]
FX We thank Elizabeth Alf, Carmen Gennarini, Michael M. Myers, J. David
Nugent, Michele Pasamba, Albany Perez, Kimon Violaris, and Jessica
Wilson for help with many aspects of this project. This research was
supported by the Sackler Institute of Developmental Psychobiology at
Columbia University and by National Institutes of Health Grants R37
HD032774 (to W.P.F.), T32 MH018264 (to D.L.B., I.-M.E., and A.R.T.), and
R01 MH068073 (to P.D.B.).
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TC 23
Z9 23
PU NATL ACAD SCIENCES
PI WASHINGTON
PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA
SN 0027-8424
J9 P NATL ACAD SCI USA
JI Proc. Natl. Acad. Sci. U. S. A.
PD JUN 1
PY 2010
VL 107
IS 22
BP 10320
EP 10323
DI 10.1073/pnas.1005061107
PG 4
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 603ZD
UT WOS:000278246000073
PM 20479232
ER
PT J
AU Rudan, I
AF Rudan, Igor
TI NEW TECHNOLOGIES PROVIDE INSIGHTS INTO GENETIC BASIS OF PSYCHIATRIC
DISORDERS AND EXPLAIN THEIR CO-MORBIDITY
SO PSYCHIATRIA DANUBINA
LA English
DT Article; Proceedings Paper
CT 24th Danube Congress of Psychiatry
CY MAY 05-08, 2010
CL Zagreb, CROATIA
SP Danubian Psychiat Assoc
DE psychiatric diseases; genetics; human genome; genome-wide association
studies; co-morbidity
ID BIPOLAR DISORDER; SCHIZOPHRENIA; FUTURE
AB The completion of Human Genome Project and the "HapMap" project was followed by translational activities from companies within the private sector. This led to the introduction of genome-wide scans based on hundreds of thousands of single nucleotide polymorphysms (SNP). These scans were based on common genetic variants in human populations. This new and powerful technology was then applied to the existing DNA-based datasets with information on psychiatric disorders. As a result, an unprecedented amount of novel scientific insights related to the underlying biology and genetics of psychiatric disorders was obtained. The dominant design of these studies, so called "genome-wide association studies" (GWAS), used statistical methods which minimized the risk of false positive reports and provided much greater power to detect genotype-phenotype associations. All findings were entirely data-driven rather than hypothesis-driven, which often made it difficult for researchers to understand or interpret the findings. Interestingly, this work in genetics is indicating how non-specific some genes are for psychiatric disorders, having associations in common for schizophrenia, bipolar disorder and autism. This suggests that the earlier stages of psychiatric disorders may be multi-valent and that early detection, coupled with a clearer understanding of the environmental factors, may allow prevention. At the present time, the rich "harvest" from GWAS still has very limited power to predict the variation in psychiatric disease status at individual level, typically explaining less than 5% of the total risk variance. The most recent studies of common genetic variation implicated the role of major histocompatibility complex in schizophrenia and other disorders. They also provided molecular evidence for a substantial polygenic component to the risk of psychiatric diseases, involving thousands of common alleles of very small effect. The studies of structural genetic variation, such as copy number variants (CNV), coupled with the efforts targeting rare genetic variation (using the emerging whole-genome "deep" sequencing technologies) will become the area of the greatest interest in the field of genetic epidemiology. This will be complemented by the studies of epigenetic phoenomena, changes of expression at a large scale and understanding gene-gene interactions in complex networks using systems biology approaches. A deeper understanding of the underlying biology of psychiatric disorders is essential to improve diagnoses and therapies of these diseases. New technologies - genome-wide association studies, imaging and the optical manipulation of neural circuits are promising to provide novel insights and lead to new treatments.
C1 [Rudan, Igor] Univ Split, Croatian Ctr Global Hlth, Fac Med, Split, Croatia.
[Rudan, Igor] Univ Edinburgh, Sch Med, Ctr Populat Hlth Sci, Edinburgh EH8 9YL, Midlothian, Scotland.
RP Rudan, I (reprint author), Univ Split, Croatian Ctr Global Hlth, Fac Med, Split, Croatia.
EM irudan@hotmail.com
RI Rudan, Igor/I-1467-2012
OI Rudan, Igor/0000-0001-6993-6884
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NR 14
TC 11
Z9 11
PU MEDICINSKA NAKLADA
PI ZAGREB
PA VLASKA 69, HR-10000 ZAGREB, CROATIA
SN 0353-5053
J9 PSYCHIAT DANUB
JI Psychiatr. Danub.
PD JUN
PY 2010
VL 22
IS 2
BP 190
EP 192
PG 3
WC Psychiatry
SC Psychiatry
GA 616JT
UT WOS:000279206200008
PM 20562745
ER
PT J
AU Kantojarvi, K
Onkamo, P
Vanhala, R
Alen, R
Hedman, M
Sajantila, A
Nieminen-von Wendt, T
Jarvela, I
AF Kantojarvi, Katri
Onkamo, Paivi
Vanhala, Raija
Alen, Reija
Hedman, Minttu
Sajantila, Antti
Nieminen-von Wendt, Taina
Jarvela, Irma
TI Analysis of 9p24 and 11p12-13 regions in autism spectrum disorders:
rs1340513 in the JMJD2C gene is associated with ASDs in Finnish sample
SO PSYCHIATRIC GENETICS
LA English
DT Article
DE autism spectrum disorder; autism; JMJD2C; obsessive compulsive disorder;
9p24; SLC1A1
ID OBSESSIVE-COMPULSIVE DISORDER; SEROTONIN TRANSPORTER GENE;
SUSCEPTIBILITY LOCUS; REPETITIVE BEHAVIOR; LINKAGE; SLC1A1; CNTNAP2;
RISK; EPIDEMIOLOGY; RETARDATION
AB Objective Autism spectrum disorders (ASD) often show obsessive repetitive symptoms that are characteristic to obsessive-compulsive disorder (OCD). Aberrant glutamate function has been suggested to a risk for both ASDs and OCD. Considering the common metabolic pathway and recent results from association studies both in OCD and ASDs, a question, whether there is common molecular background in ASDs and OCD, was raised.
Methods Ten single nucleotide polymorphisms (SNPs) at 9p24 and 11p12-p13 containing glutamate transporter genes SLC1A1 and SLC1A2 and their neighboring regions in 175 patients with ASDs and 216 controls of Finnish origin were analyzed using real-time-PCR or direct sequencing.
Results The strongest association was detected with rs1340513 in the JMJD2C gene at 9p24.1 (P=0.007; corrected P=0.011) that is the same SNP associated with infantile autism (P=0.0007) in the autism genome project consortium (2007). No association was detected at 11p12-p13 with ASD. Interestingly, the strongest association in OCD has been found at rs301443 (P=0.000067) residing between SLC1A1 and JMJD2C at 9p24.
Conclusion In summary, our results give evidence for a possible common locus for OCD and ASDs at 9p24. We speculate that the area may represent a special candidate region for obsessive repetitive symptoms in ASDs. Psychiatr Genet 20:102-108 (C) 2010 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
C1 [Kantojarvi, Katri; Jarvela, Irma] Univ Helsinki, Dept Med Genet, FIN-00014 Helsinki, Finland.
[Onkamo, Paivi] Univ Helsinki, Dept Biol & Environm Sci, FIN-00014 Helsinki, Finland.
[Hedman, Minttu; Sajantila, Antti] Univ Helsinki, Dept Forens Med, FIN-00014 Helsinki, Finland.
[Vanhala, Raija; Nieminen-von Wendt, Taina] Univ Helsinki, Hosp Children & Adolescents, FIN-00014 Helsinki, Finland.
[Alen, Reija] Jyvaskyla Cent Hosp, Dept Child Neurol, Jyvaskyla, Finland.
[Jarvela, Irma] Univ Helsinki, Cent Hosp, Mol Genet Lab, FIN-00014 Helsinki, Finland.
RP Kantojarvi, K (reprint author), Univ Helsinki, Dept Med Genet, POB 63, FIN-00014 Helsinki, Finland.
EM katri.kantojarvi@helsinki.fi
RI Jarvela, Irma/L-5836-2013
FU European Union [LSHM-CT-2005-512158]; Helsinki University Hospital
[TYH7227]
FX The authors are grateful to the families for participation. The authors
also thank Milla Ihalainen, Tarja Jarvinen, and Ulla Sarin-Seppanen for
their excellent technical assistance. The project was funded by the
European Union (LSHM-CT-2005-512158) and Helsinki University Hospital
research funding (TYH7227).
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NR 53
TC 20
Z9 20
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0955-8829
J9 PSYCHIAT GENET
JI Psychiatr. Genet.
PD JUN
PY 2010
VL 20
IS 3
BP 102
EP 108
DI 10.1097/YPG.0b013e32833a2080
PG 7
WC Genetics & Heredity; Neurosciences
SC Genetics & Heredity; Neurosciences & Neurology
GA 601OV
UT WOS:000278072700003
PM 20410850
ER
PT J
AU Li, XP
Hu, ZM
He, YQ
Xiong, ZM
Long, ZG
Peng, Y
Bu, FX
Ling, J
Xun, GL
Mo, XY
Pan, Q
Zhao, JP
Xia, K
AF Li, Xiaoping
Hu, Zhengmao
He, Yiqun
Xiong, Zhimin
Long, Zhigao
Peng, Yu
Bu, Fengxiao
Ling, Jie
Xun, Guanglei
Mo, Xiaoyun
Pan, Qian
Zhao, Jingping
Xia, Kun
TI Association analysis of CNTNAP2 polymorphisms with autism in the Chinese
Han population
SO PSYCHIATRIC GENETICS
LA English
DT Article
DE autism; CNTNAP2; single nucleotide polymorphism; transmission
disequilibrium test
ID SPECTRUM DISORDERS; NEUREXIN SUPERFAMILY; GENOMEWIDE SCREEN; MYELINATED
AXONS; K+ CHANNELS; LINKAGE; GENES; ETIOLOGY; CASPR2; MEMBER
AB Objectives Autism is a neurodevelopmental disorder, and genetic factors play an important role in its pathogenesis. Earlier findings suggest the CNTNAP2 as a predisposition locus of autism, but no study has been carried out on the possible association of CNTNAP2 with autism in the Chinese Han population.
Methods In this study, three single nucleotide polymorphisms located within the CNTNAP2 were genotyped in 185 Chinese Han autistic families by polymerase chain reaction-restriction fragment length polymorphism analysis, followed by a transmission disequilibrium test.
Results The results show that a common noncoding variant (rs10500171) is associated with the increased risk for autism, and haplotype T-A (rs7794745-rs10500171, P=0.011) and haplotype A-T-A (rs10244837-rs7794745-rs10500171, P=0.032) also showed evidence of association.
Conclusion The results of family-based association study suggested that the CNTNAP2 is a susceptibility gene of autism in the Chinese Han population. Psychiatr Genet 20:113-117 (C) 2010 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
C1 [Li, Xiaoping; Hu, Zhengmao; Long, Zhigao; Peng, Yu; Bu, Fengxiao; Ling, Jie; Mo, Xiaoyun; Pan, Qian; Xia, Kun] Cent S Univ, State Key Lab Med Genet, Changsha 410078, Hunan, Peoples R China.
[He, Yiqun; Xiong, Zhimin; Xun, Guanglei; Zhao, Jingping] Cent S Univ, Xaingya Hosp 2, Mental Hlth Inst, Changsha 410011, Hunan, Peoples R China.
RP Xia, K (reprint author), Cent S Univ, State Key Lab Med Genet, 110 Xiangya Rd, Changsha 410078, Hunan, Peoples R China.
EM zhaojingpinghunan@yahoo.com.cn; xiakun@sklmg.edu.cn
FU National Natural Science Foundation of China [30630062, 30600247];
Chinese National Programs for Fundamental Research and Development (973
Program) [2004CB518601]
FX The authors thank all families for their understanding and participation
in this study. This research is supported by the National Natural
Science Foundation of China (Grant No. 30630062 and Grant No. 30600247)
and the major Project of Chinese National Programs for Fundamental
Research and Development (973 Program) (Grant No. 2004CB518601).
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NR 23
TC 17
Z9 18
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0955-8829
J9 PSYCHIAT GENET
JI Psychiatr. Genet.
PD JUN
PY 2010
VL 20
IS 3
BP 113
EP 117
DI 10.1097/YPG.0b013e32833a216f
PG 5
WC Genetics & Heredity; Neurosciences
SC Genetics & Heredity; Neurosciences & Neurology
GA 601OV
UT WOS:000278072700005
PM 20414140
ER
PT J
AU Doyle, G
AF Doyle, Griffin
TI Infant/Child Mental Health, Early Intervention, and Relationship-Based
Therapies: A Neurorelational Framework for Interdisciplinary Practice
SO PSYCHIATRY-INTERPERSONAL AND BIOLOGICAL PROCESSES
LA English
DT Book Review
ID AUTISM; CHILDREN
RP Doyle, G (reprint author), 4400 East West Highway,Suite 329, Bethesda, MD 20814 USA.
EM griffdoyle@mac.com
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NR 22
TC 0
Z9 0
PU GUILFORD PUBLICATIONS INC
PI NEW YORK
PA 72 SPRING STREET, NEW YORK, NY 10012 USA
SN 0033-2747
J9 PSYCHIATRY
JI Psychiatry-Interpers. Biol. Process.
PD SUM
PY 2010
VL 73
IS 2
BP 198
EP 204
PG 7
WC Psychiatry
SC Psychiatry
GA 608MC
UT WOS:000278587300012
ER
PT J
AU Kim, SM
Han, DH
Lyoo, HS
Min, KJ
Kim, KH
Renshaw, P
AF Kim, Sun Mi
Han, Doug Hyun
Lyoo, Hang Sik
Min, Kyung Joon
Kim, Kyung Ho
Renshaw, Perry
TI Exposure to Environmental Toxins in Mothers of Children with Autism
Spectrum Disorder
SO PSYCHIATRY INVESTIGATION
LA English
DT Article
DE Environmental toxins; Autism spectrum disorders; Child behaviors
ID POLYBROMINATED DIPHENYL ETHERS; BROMINATED FLAME-RETARDANT; PERINATAL
EXPOSURE; NEONATAL EXPOSURE; BISPHENOL-A; POLYCHLORINATED-BIPHENYLS;
SPONTANEOUS BEHAVIOR; BRAIN-DEVELOPMENT; DUTCH CHILDREN; SCHOOL-AGE
AB Objective Environmental pollutants, especially environmental toxins (ET), may have the potential to disrupt neurodevelopmental pathways during early brain development. This study was designed to test our hypothesis that mothers with autism spectrum disorder (ASD) children would have less knowledge about ET and more chance to be exposed to ET than mothers with healthy children (MHC).
Methods One hundred and six biologic mothers with ASD children (MASD) and three hundred twenty four biologic mothers with healthy children MHC were assessed using two questionnaires asking about ET.
Results The total score in response to questions related to knowledge about ET in MHC was higher than that in MASD. The possibility of exposure to ET was higher in MASD than MHC. MASD showed higher sub-scale scores in terms of exposures to canned food, plastics, waste incinerators, old electronics, microwavable food, and textiles.
Conclusion The current results show that reduced knowledge about ET and greater exposure to ET may be associated with autism spectrum disorder. Psychiatry Investig 2010;7:122-127
C1 [Kim, Sun Mi; Han, Doug Hyun; Min, Kyung Joon] Chung Ang Univ, Coll Med, Dept Psychiat, Seoul 156755, South Korea.
[Lyoo, Hang Sik] Tanbang Elementary Sch, Taejon, South Korea.
[Kim, Kyung Ho] Univ Calif Davis, Sch Vet Med, Dept Mol Biosci, Davis, CA 95616 USA.
[Renshaw, Perry] Univ Utah, Inst Brain, Salt Lake City, UT USA.
RP Han, DH (reprint author), Chung Ang Univ, Coll Med, Dept Psychiat, 65-207 Hangang Ro 3 Ga, Seoul 156755, South Korea.
EM hduk@yahoo.com
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NR 47
TC 6
Z9 6
PU KOREAN NEUROPSYCHIATRIC ASSOC
PI SEOUL
PA RN 522, G-FIVE CENTRAL PLAZA 1685-8 SEOCHO 4-DONG, SEOCHO-GU, SEOUL,
137-882, SOUTH KOREA
SN 1738-3684
J9 PSYCHIAT INVEST
JI Psychiatry Investig.
PD JUN
PY 2010
VL 7
IS 2
BP 122
EP 127
DI 10.4306/pi.2010.7.2.122
PG 6
WC Psychiatry
SC Psychiatry
GA 614PN
UT WOS:000279072300007
PM 20577621
ER
PT J
AU Zander, E
Dahlgren, SO
AF Zander, Eric
Dahlgren, Sven Olof
TI WISC-III Index Score Profiles of 520 Swedish Children With Pervasive
Developmental Disorders
SO PSYCHOLOGICAL ASSESSMENT
LA English
DT Article
DE Wechsler Intelligence Scale for Children-Third Edition; profile
analysis; autistic disorder; Asperger's disorder; PDD-NOS
ID WECHSLER INTELLIGENCE SCALE; HIGH-FUNCTIONING AUTISM; LONG-TERM
STABILITY; ASPERGER-SYNDROME; SYMPTOM PROFILES; SUBTEST ANALYSIS;
PDD-NOS; DSM-IV; EDITION; ACHIEVEMENT
AB WISC-III (Wechsler, 1991) index score profiles and their characteristics were examined with traditional statistics in a large Swedish sample consisting of children with autistic disorder (n = 85). Asperger's disorder (n = 341), or pervasive developmental disorders not otherwise specified (PDD-NOS: n = 94). There was a clear and significant difference in level between children with Asperger's disorder, who performed in the average range according to the Swedish standardization, and children with either autistic disorder or PDD-NOS, who performed below the average range (almost 2 standard deviations below the mean), but few other differences between the diagnostic groups were found. The variation in this sample, compared with the Swedish standardization, was generally larger in regard to the size of standard deviations and to the proportion of individuals who exhibited significant differences between indices. The result implied that a WISC-III profile could not be used to discriminate between the different PDDs.
C1 [Zander, Eric] Karolinska Inst, Child & Adolescent Psychiat Div, Dept Womens & Childrens Hlth, Stockholm, Sweden.
[Zander, Eric; Dahlgren, Sven Olof] Stockholm Cty Council, Habilitat Serv, Res & Dev Unit, Stockholm, Sweden.
[Dahlgren, Sven Olof] Autismforum, Stockholm, Sweden.
RP Zander, E (reprint author), BUP Farsta, Neuropsychiat Unit SE, Storforsplan 36,Plan 7, SE-12347 Farsta, Sweden.
EM eric.zander@sll.se
RI Zander, Eric/G-1064-2013
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NR 78
TC 6
Z9 7
PU AMER PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA
SN 1040-3590
J9 PSYCHOL ASSESSMENT
JI Psychol. Assess.
PD JUN
PY 2010
VL 22
IS 2
BP 213
EP 222
DI 10.1037/a0018335
PG 10
WC Psychology, Clinical
SC Psychology
GA 609OF
UT WOS:000278665600002
PM 20528049
ER
PT J
AU Moines, LESM
Allen, DN
Puente, AE
Neblina, C
AF Moines, Liza E. San Miguel
Allen, Daniel N.
Puente, Antonio E.
Neblina, Cris
TI Validity of the WISC-IV Spanish for a Clinically Referred Sample of
Hispanic Children
SO PSYCHOLOGICAL ASSESSMENT
LA English
DT Article
DE WISC-IV Spanish; Hispanic children; learning disabilities; ADHD; Puerto
Rican children
ID TRAUMATIC BRAIN-INJURY; HIGH-FUNCTIONING AUTISM; CRITERION VALIDITY;
INTELLIGENCE SCALE; ADOLESCENTS; PROFILES; EDITION
AB The Wechsler Intelligence Scale for Children (WISC) is the most commonly used intelligence test for children. Five years ago, a Spanish version of the WISC-IV was published (WISC-IV Spanish: Wechsler. 2005). hut a limited amount of published information is available regarding its utility when assessing clinical samples. The current study included 107 children who were Spanish speaking and of Puerto Rican descent that had been administered the WISC-IV Spanish. They were subdivided into a clinical sample of 35 children with diagnoses of various forms of brain dysfunction (primarily learning disability. attention-deficit/hyperactivity disorder, and epilepsy) and a comparison group made up of 72 normal children who were part of the WISC-IV Spanish version standardization sample. Comparisons between these groups and the standardization sample were performed for the WISC-IV Spanish index and subtest scores. Results indicated that the clinical sample performed worse than the comparison samples on the Working Memory and Processing Speed Indexes, although findings varied to some extent depending on whether the clinical group was compared with the normal comparison group or the standardization sample. These findings provide support for the criterion validity of the WISC-IV Spanish when it is used to assess a clinically referred sample with brain dysfunction.
C1 [Moines, Liza E. San Miguel] Univ Puerto Rico, Sch Med, Neurol Sect, Child Neurol Program, San Juan, PR 00936 USA.
[Allen, Daniel N.; Neblina, Cris] Univ Nevada, Dept Psychol, Las Vegas, NV 89154 USA.
[Puente, Antonio E.] Univ N Carolina, Dept Psychol, Wilmington, NC USA.
RP Moines, LESM (reprint author), Univ Puerto Rico, Sch Med, Neurol Sect, Child Neurol Program, Med Sci Campus, San Juan, PR 00936 USA.
EM lsanmiguel@rcm.upr.edu
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Allen DN, 2009, CHILD NEUROPSYCHOL, V15, P543, DOI 10.1080/09297040902748234
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NR 27
TC 1
Z9 1
PU AMER PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA
SN 1040-3590
J9 PSYCHOL ASSESSMENT
JI Psychol. Assess.
PD JUN
PY 2010
VL 22
IS 2
BP 465
EP 469
DI 10.1037/a0018895
PG 5
WC Psychology, Clinical
SC Psychology
GA 609OF
UT WOS:000278665600026
ER
PT J
AU Welch, KA
Stanfield, AC
Moorhead, TW
Haga, K
Owens, DCG
Lawrie, SM
Johnstone, EC
AF Welch, K. A.
Stanfield, A. C.
Moorhead, T. W.
Haga, K.
Owens, D. C. G.
Lawrie, S. M.
Johnstone, E. C.
TI Amygdala volume in a population with special educational needs at high
risk of schizophrenia
SO PSYCHOLOGICAL MEDICINE
LA English
DT Article
DE Amygdala; cognitive impairment; high risk; learning disability; magnetic
resonance imaging; schizophrenia
ID EDINBURGH HIGH-RISK; MILD LEARNING-DISABILITY; VOXEL-BASED MORPHOMETRY;
COMORBID SCHIZOPHRENIA; PSYCHOTIC SYMPTOMS; BRAIN STRUCTURE;
METAANALYSIS; ADOLESCENTS; AUTISM; MRI
AB Background. The mildly learning disabled population has a three-fold elevated risk for schizophrenia. It has been proposed that in some individuals this cognitive limitation is a pre-psychotic manifestation of early onset schizophrenia. We examined clinical and neuroanatomical measures of a putative extended phenotype of schizophrenia in an adolescent population receiving special educational assistance. We predicted that people with intellectual impairment and schizotypal features would exhibit amygdala volume reduction as one of the neuroanatomical abnormalities associated with schizophrenia.
Method. Assessment by clinical interview, neuropsychological assessment and magnetic resonance imaging scanning was carried out in 28 intellectually impaired individuals identified as being at elevated risk of schizophrenia due to the presence of schizotypal traits, 39 intellectually impaired controls and 29 non-intellectually impaired controls. Amygdala volume was compared in these three groups and the relationship between symptomatology and amygdala volume investigated.
Results. Right amygdala volume was significantly increased in the elevated risk group compared with the intellectually impaired controls (p= 0.05). A significant negative correlation was seen between left amygdala volume and severity of negative symptoms within this group (p <0.05), but not in either control group.
Conclusions. Intellectually impaired subjects judged to be at elevated risk of schizophrenia on the basis of clinical assessment exhibit structural imaging findings which distinguish them from the generality of learning disabled subjects. Within this population reduced amygdala volume may be associated with negative-type symptoms and be part of an extended phenotype that reflects particularly elevated risk and/or early manifestations of the development of psychosis.
C1 [Welch, K. A.; Stanfield, A. C.; Moorhead, T. W.; Haga, K.; Owens, D. C. G.; Lawrie, S. M.; Johnstone, E. C.] Univ Edinburgh, Sch Mol & Clin Med, Div Psychiat, Edinburgh EH10 5HF, Midlothian, Scotland.
RP Welch, KA (reprint author), Univ Edinburgh, Royal Edinburgh Hosp, Sch Mol & Clin Med, Div Psychiat, Edinburgh EH10 5HF, Midlothian, Scotland.
EM kwelch1@staffmail.ed.ac.uk
FU United Kingdom Medical Research Council Programme; Sackler Foundation;
BMA
FX We are deeply grateful to the participants and their families for their
generous assistance. We thank the staff at the Division of Pyschiatry
involved in recruiting the sample and those at the Scottish Higher
Education Funding Council Brain Imaging Research Centre. This research
was funded by a United Kingdom Medical Research Council Programme Grant
awarded to E.C.J. T.W.M. was funded as part of this grant. S.M.L. was
supported by the Sackler Foundation. K.H. was funded by a BMA grant to
A.C.S.
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NR 43
TC 8
Z9 8
PU CAMBRIDGE UNIV PRESS
PI NEW YORK
PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA
SN 0033-2917
J9 PSYCHOL MED
JI Psychol. Med.
PD JUN
PY 2010
VL 40
IS 6
BP 945
EP 954
DI 10.1017/S0033291709990870
PG 10
WC Psychology, Clinical; Psychiatry; Psychology
SC Psychology; Psychiatry
GA 603WZ
UT WOS:000278240100007
PM 19732477
ER
PT J
AU Egan, CE
Barnes-Holmes, D
AF Egan, Claire E.
Barnes-Holmes, Dermot
TI ESTABLISHING MAND EMERGENCE: THE EFFECTS OF THREE TRAINING PROCEDURES
AND MODIFIED ANTECEDENT CONDITIONS
SO PSYCHOLOGICAL RECORD
LA English
DT Article
DE autism; expressive language; mand; receptive language; tact
ID YOUNG-CHILDREN; BEHAVIOR; LANGUAGE; AUTISM; TACTS
AB This study examined the effects of a modified antecedent during probes for emergent mands following listener versus tact training for children with autism. Eight students, aged 7 to 11, were trained to respond to 3 sets of relational responses (front/back, left/right, on/under), each assigned a nonsense label. Three training types were evaluated: listener training, tact training, and listener-tact training combined. Following the experimental training, probes for emergent mands were conducted under modified antecedent conditions. Results showed that modified antecedent conditions were critical in demonstrating mand emergence for some participants.
C1 [Egan, Claire E.; Barnes-Holmes, Dermot] Natl Univ Ireland, Maynooth, Kildare, Ireland.
RP Egan, CE (reprint author), Hong Kong Inst Educ, Dept Special Educ & Counselling, 10 Lo Ping Rd, Tai Po, Hong Kong, Peoples R China.
EM claire@ied.edu.hk
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NR 23
TC 2
Z9 2
PU PSYCHOLOGICAL RECORD
PI CARBONDALE
PA SOUTHERN ILLINOIS UNIV, REHABILITATION INSTITUTE, CARBONDALE, IL
62901-4609 USA
SN 0033-2933
J9 PSYCHOL REC
JI Psychol. Rec.
PD SUM
PY 2010
VL 60
IS 3
BP 473
EP 487
PG 15
WC Psychology, Multidisciplinary
SC Psychology
GA 629QU
UT WOS:000280215600006
ER
PT J
AU Murphy, C
Barnes-Holmes, D
AF Murphy, Carol
Barnes-Holmes, Dermot
TI ESTABLISHING COMPLEX DERIVED MANDING WITH CHILDREN WITH AND WITHOUT A
DIAGNOSIS OF AUTISM
SO PSYCHOLOGICAL RECORD
LA English
DT Article
DE autism; children; derived mands; language; more/less relations
ID DISCRIMINATION RESPONSE FUNCTIONS; SEVERE DEVELOPMENTAL-DISABILITIES;
SKINNERS VERBAL-BEHAVIOR; RELATIONAL FRAME-THEORY; BASE-LINE RELATIONS;
STIMULUS EQUIVALENCE; LESS-THAN; TRANSFORMATION; ACCORDANCE; OPERATIONS
AB Participants were four 14-year-old adolescent boys with diagnosed autism spectrum disorder and 3 children without diagnosed learning disorders aged 5 to 11. Training trials to establish more/less relational functions for 2 stimuli (X and Y, respectively) were interspersed with training trials to establish comparative relations among 5 other arbitrary stimuli (Le., A is more than B, B is more than C, C is more than D, and D is more than E). Subsequent tests showed a derived transformation of functions for 7 participants (i.e., derived more/less mands). Exemplar training was required with 2 children. An ABA design with 3 participants showed manding was controlled by trained relations.
C1 [Murphy, Carol; Barnes-Holmes, Dermot] Natl Univ Ireland, Maynooth, Kildare, Ireland.
RP Murphy, C (reprint author), Natl Univ Ireland Maynooth, Dept Psychol, Maynooth, Kildare, Ireland.
EM Carol.A.Murphy@nuim.ie
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NR 26
TC 1
Z9 1
PU PSYCHOLOGICAL RECORD
PI CARBONDALE
PA SOUTHERN ILLINOIS UNIV, REHABILITATION INSTITUTE, CARBONDALE, IL
62901-4609 USA
SN 0033-2933
J9 PSYCHOL REC
JI Psychol. Rec.
PD SUM
PY 2010
VL 60
IS 3
BP 489
EP 503
PG 15
WC Psychology, Multidisciplinary
SC Psychology
GA 629QU
UT WOS:000280215600007
ER
PT J
AU Nietlisbach, G
Maercker, A
Rossler, W
Haker, H
AF Nietlisbach, Gabriela
Maercker, Andreas
Roessler, Wulf
Haker, Helene
TI ARE EMPATHIC ABILITIES IMPAIRED IN POSTTRAUMATIC STRESS DISORDER?
SO PSYCHOLOGICAL REPORTS
LA English
DT Article
ID HIGH-FUNCTIONING AUTISM; MIRROR-NEURON SYSTEM; ASPERGER-SYNDROME; SOCIAL
ACKNOWLEDGMENT; RISK-FACTORS; SELF; SCHIZOPHRENIA; COGNITION; TRAUMA;
ADULTS
AB Trauma survivors with PTSD show social interaction and relationship impairments. It is hypothesized that traumatic experiences lead to known PTSD symptoms, empathic ability impairment, and difficulties in sharing affective, emotional, or cognitive states. A PTSD group (N = 16) and a nontraumatized Control group (N = 16) were compared on empathic abilities, namely the Empathic Resonance Test, Reading the Mind in the Eyes Test, and Faux Pas Test. The Interpersonal Reactivity Index as a self-report measure of empathy and measures of nonsocial cognitive functions, namely the Verbal Fluency Test, the Five-Point Test, and the Stroop Test, were also administered. The PTSD group showed lower empathic resonance. No clear indications of other impairments in social cognitive functions were found. The PTSD group had significantly higher personal distress. Empathic resonance impairments did not correlate with subjective severity of PTSD symptomatology. This article discusses whether impaired empathic resonance in PTSD trauma survivors is a consequence of trauma itself or a protective coping strategy.
C1 [Nietlisbach, Gabriela; Maercker, Andreas] Univ Zurich, Dept Psychol, CH-8050 Zurich, Switzerland.
[Roessler, Wulf; Haker, Helene] Psychiat Univ Hosp Zurich, Dept Gen & Social Psychiat, Zurich, Switzerland.
RP Nietlisbach, G (reprint author), Univ Zurich, Dept Psychol, Binzmuehlestr 14-17, CH-8050 Zurich, Switzerland.
EM gabriela.nietlisbach@zuerich.ch
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NR 38
TC 21
Z9 21
PU AMMONS SCIENTIFIC, LTD
PI MISSOULA
PA PO BOX 9229, MISSOULA, MT 59807-9229 USA
SN 0033-2941
J9 PSYCHOL REP
JI Psychol. Rep.
PD JUN
PY 2010
VL 106
IS 3
BP 832
EP 844
DI 10.2466/PR0.106.3.832-844
PG 13
WC Psychology, Multidisciplinary
SC Psychology
GA 626YS
UT WOS:000280005100021
PM 20712172
ER
PT J
AU Kokkinaki, M
Lee, TL
He, ZP
Jiang, JJ
Golestaneh, N
Hofmann, MC
Chan, WY
Dym, M
AF Kokkinaki, Maria
Lee, Tin-Lap
He, Zuping
Jiang, Jiji
Golestaneh, Nady
Hofmann, Marie-Claude
Chan, Wai-Yee
Dym, Martin
TI Age affects gene expression in mouse spermatogonial stem/progenitor
cells
SO REPRODUCTION
LA English
DT Article
ID COLONY-STIMULATING FACTOR-1; ADVANCING PATERNAL AGE; LINE STEM-CELLS;
SELF-RENEWAL; UNDIFFERENTIATED SPERMATOGONIA; NEUROTROPHIC FACTOR; SEMEN
QUALITY; NICHE; AUTISM; TESTIS
AB Spermatogenesis in man starts with spermatogonial stem cells (SSCs), and leads to the production of sperm in similar to 64 days, common to old and young men. Sperm from elderly men are functional and able to fertilize eggs and produce offspring, even though daily sperm production is more than 50% lower and damage to sperm DNA is significantly higher in older men than in those who are younger. Our hypothesis is that the SSC/spermatogonial progenitors themselves age. To test this hypothesis, we studied the gene expression profile of mouse SSC/progenitor cells at several ages using microarrays. After sequential enzyme dispersion, we purified the SSC/progenitors with immunomagnetic cell sorting using an antibody to GFRA1, a known SSC/progenitor cell marker. RNA was isolated and used for the in vitro synthesis of amplified and labeled cRNAs that were hybridized to the Affymetrix mouse genome microarrays. The experiments were repeated twice with different cell preparations, and statistically significant results are presented. Quantitative RT-PCR analysis was used to confirm the microarray results. Comparison of four age groups (6 days, 21 days, 60 days, and 8 months old) showed a number of genes that were expressed specifically in the older mice. Two of them (i.e. Icam1 and Selp) have also been shown to mark aging hematopoietic stem cells. On the other hand, the expression levels of the genes encoding the SSC markers Gfra1 and Plzf did not seem to be significantly altered by age, indicating that age affects only certain SSC/progenitor properties. Reproduction (2010) 139 1011-1020
C1 [Kokkinaki, Maria; He, Zuping; Jiang, Jiji; Golestaneh, Nady; Chan, Wai-Yee; Dym, Martin] Georgetown Univ, Med Ctr, Dept Biochem & Mol & Cellular Biol, Washington, DC 20057 USA.
[Lee, Tin-Lap; Chan, Wai-Yee] NICHHD, NIH, Bethesda, MD 20892 USA.
[Hofmann, Marie-Claude] Univ Illinois, Dept Vet Biosci, Urbana, IL 61802 USA.
RP Dym, M (reprint author), Georgetown Univ, Med Ctr, Dept Biochem & Mol & Cellular Biol, 3900 Reservoir Rd NW, Washington, DC 20057 USA.
EM dymm@georgetown.edu
FU National Institutes of Health (NIH) [HD044543, HD033728]; Eunice Kennedy
Shriver National Institute of Child Health and Human Development
FX This research was supported by the Intramural Research Program of the
National Institutes of Health (NIH), Eunice Kennedy Shriver National
Institute of Child Health and Human Development (W-Y Chan), and NIH
grants HD044543 (M-C Hofmann) and HD033728 (M Dym).
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NR 53
TC 14
Z9 14
PU BIOSCIENTIFICA LTD
PI BRISTOL
PA EURO HOUSE, 22 APEX COURT WOODLANDS, BRADLEY STOKE, BRISTOL BS32 4JT,
ENGLAND
SN 1470-1626
J9 REPRODUCTION
JI Reproduction
PD JUN
PY 2010
VL 139
IS 6
BP 1011
EP 1020
DI 10.1530/REP-09-0566
PG 10
WC Developmental Biology; Reproductive Biology
SC Developmental Biology; Reproductive Biology
GA 597SK
UT WOS:000277781400008
PM 20371641
ER
PT J
AU Newman, C
Cashin, A
Waters, CD
AF Newman, Claire
Cashin, Andrew
Waters, Cheryl D.
TI A Modified Hermeneutic Phenomenological Approach Toward Individuals Who
Have Autism
SO RESEARCH IN NURSING & HEALTH
LA English
DT Article
DE hermeneutic phenomenology; autism; Martin Heidegger
ID INTERPRETIVE PHENOMENOLOGY; ASPERGER-SYNDROME; NURSING-RESEARCH;
SPECTRUM; DIAGNOSIS
AB Individuals with autism have a unique cognitive processing style characterized by impaired abstraction, impaired theory of mind, and visual as opposed to linguistic processing of information. A consequence of this unique cognitive processing style is that traditional ways of hermeneutical phenomenological examination may be inadequate to achieve the kind of understanding of experience toward which this method is directed. In order to stay true to Heidegger's hermeneutic phenomenology, we needed to develop modifications to this research methodology, which include the use of visual aids to promote participant engagement and access the eidetic memory of a participant with autism, so as to elicit concrete descriptors of an experience. (C) 2010 Wiley Periodicals, Inc. Res Nurs Health 33:265-271, 2010
C1 [Newman, Claire; Waters, Cheryl D.] Univ Technol Sydney, Fac Nursing Midwifery & Hlth, Sydney, NSW 2036, Australia.
[Newman, Claire] New S Wales Justice Hlth, Professorial Unit, Sydney, NSW 2036, Australia.
[Cashin, Andrew] So Cross Univ, Sch Hlth & Human Sci, Lismore, NSW 2480, Australia.
RP Newman, C (reprint author), Univ Technol Sydney, Fac Nursing Midwifery & Hlth, Suite 302,Level 2,Westfield Off Tower,152 Bunnero, Sydney, NSW 2036, Australia.
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NR 32
TC 3
Z9 3
PU JOHN WILEY & SONS INC
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 0160-6891
J9 RES NURS HEALTH
JI Res. Nurs. Health
PD JUN
PY 2010
VL 33
IS 3
BP 265
EP 271
DI 10.1002/nur.20382
PG 7
WC Nursing
SC Nursing
GA 599TH
UT WOS:000277935700009
PM 20499396
ER
PT J
AU Durkin, K
AF Durkin, Kevin
TI Videogames and Young People With Developmental Disorders
SO REVIEW OF GENERAL PSYCHOLOGY
LA English
DT Article
DE videogames; developmental disorders; autism; Asperger syndrome; ADHD;
specific language impairment; dopamine
ID DEFICIT-HYPERACTIVITY DISORDER;
ATTENTION-DEFICIT/HYPERACTIVITY-DISORDER; AUTISM SPECTRUM DISORDERS;
HIGH-FUNCTIONING AUTISM; RANDOMIZED CONTROLLED-TRIAL; STRIATAL DOPAMINE
RELEASE; ELECTRONIC SCREEN MEDIA; LANGUAGE IMPAIRMENT SLI; COMPUTER GAME
PLAY; CARD SORTING TEST
AB Young people with developmental disorders experience difficulties with many cognitive and perceptual tasks, and often suffer social impairments. Yet, like typical youth, many appear to enjoy playing videogames. This review considers the appeal of videogames to individuals with autism spectrum disorders, attention deficit hyperactivity disorder, and specific language impairment. It examines how they respond to the various challenges that play entails with particular reference to sensory, cognitive, and social dimensions. It is argued that research into how these young people engage voluntarily with this dynamic and challenging medium offers great potential to extend our empirical and theoretical understanding of the disorders. Many gaps in our current knowledge are identified and several additional themes for possible future research are proposed.
C1 Univ Strathclyde, Dept Psychol, Glasgow G1 1QE, Lanark, Scotland.
RP Durkin, K (reprint author), Univ Strathclyde, Dept Psychol, 40 George St, Glasgow G1 1QE, Lanark, Scotland.
EM kevin.durkin@strath.ac.uk
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NR 224
TC 21
Z9 21
PU EDUCATIONAL PUBLISHING FOUNDATION
PI WASHINGTON
PA 750 FIRST ST, NE, WASHINGTON, DC 20002-4242 USA
SN 1089-2680
J9 REV GEN PSYCHOL
JI Rev. Gen. Psychol.
PD JUN
PY 2010
VL 14
IS 2
SI SI
BP 122
EP 140
DI 10.1037/a0019438
PG 19
WC Psychology, Multidisciplinary
SC Psychology
GA 612GY
UT WOS:000278886000008
ER
PT J
AU Koelkebeck, K
Pedersen, A
Suslow, T
Kueppers, KA
Arolt, V
Ohrmann, P
AF Koelkebeck, Katja
Pedersen, Anya
Suslow, Thomas
Kueppers, Kerstin Annika
Arolt, Volker
Ohrmann, Patricia
TI Theory of Mind in first-episode schizophrenia patients: Correlations
with cognition and personality traits
SO SCHIZOPHRENIA RESEARCH
LA English
DT Article
DE First-episode schizophrenia; Theory of Mind; Trait marker;
Neurocognitive functioning; Moving Shapes
ID HIGH-FUNCTIONING AUTISM; ASPERGER-SYNDROME; INTENTIONAL MOVEMENT;
EMPATHIC ABILITIES; ANIMATED SHAPES; MENTAL STATES; 1ST EPISODE;
RECOGNITION; DEFICITS; ALEXITHYMIA
AB Introduction: There is substantial evidence for Theory of Mind (ToM) deficits in patients with schizophrenia. Many psychotic symptoms may best be understood in light of an impaired capacity to infer one's own and other persons' mental states and to relate those to executing behavior. The aim of our study was to investigate ToM abilities in first-episode schizophrenia patients and to analyze them in relation to neuropsychological and psychopathological functioning.
Materials and methods: A modified Moving Shapes paradigm was used to assess ToM abilities in 23 first-episode patients with schizophrenia and 23 matched healthy controls. Participants had to describe animated triangles which moved (1) randomly, (2) goal-directed, or (3) in complex, socially interactive ways (TOM video sequences). Neuropsychological functioning, psychopathology, autistic and alexithymic features as well as empathetic abilities were correlated with TOM performance.
Results: Compared to healthy controls, first-episode schizophrenia patients gave more incorrect descriptions and used less ToM-related vocabulary when responding to socially complex ToM video sequences. No group differences were revealed for videos with random movements. ToM abilities correlated significantly with positive symptoms, reasoning, verbal memory performance and verbal IQ but not with empathetic abilities or autistic and alexithymic features. When controlling for reasoning, verbal memory performance and verbal IQ, the correctness of video descriptions was still significantly worse in schizophrenia patients.
Discussion: The results of our study in first-episode schizophrenia patients underline recent findings on ToM deficits in the early course of schizophrenia. Only a moderate influence of neurocognitive deficits on ToM performance was observed. Impairment in Tom abilities seems to be predominantly independent of clinical state, alexithymia and empathy. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Koelkebeck, Katja; Pedersen, Anya; Suslow, Thomas; Kueppers, Kerstin Annika; Arolt, Volker; Ohrmann, Patricia] Univ Munster, Sch Med, Dept Psychiat, D-48149 Munster, Germany.
RP Koelkebeck, K (reprint author), Univ Munster, Sch Med, Dept Psychiat, Albert Schweitzer Str 11, D-48149 Munster, Germany.
EM katja.koelkebeck@ukmuenster.de; Anya.Pedersen@ukmuenster.de;
Thomas.Suslow@ukmuenster.de; Kerstin.Kueppers@ukmuenster.de;
Volker.Arolt@ukmuenster.de; Patricia.Ohrmann@ukmuenster.ie
RI Koelkebeck, Katja/F-3977-2014
FU Uta and Chris Frith
FX We would like to thank Uta and Chris Frith and their staff members for
kindly providing the Moving Shapes paradigm and rating descriptions, as
well as for their support in the development of this study. Further, we
would also like to thank Tins Weimann for preparing the videos in a
shortened version. We would also sincerely like to thank all the
subjects for their participation in this study and all the staff
involved in the data acquisition.
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NR 71
TC 48
Z9 50
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0920-9964
J9 SCHIZOPHR RES
JI Schizophr. Res.
PD JUN
PY 2010
VL 119
IS 1-3
BP 115
EP 123
DI 10.1016/j.schres.2009.12.015
PG 9
WC Psychiatry
SC Psychiatry
GA 631JC
UT WOS:000280341700018
PM 20060686
ER
PT J
AU Hellemans, H
Roeyers, H
Leplae, W
Dewaele, T
Deboutte, D
AF Hellemans, Hans
Roeyers, Herbert
Leplae, Wouter
Dewaele, Tine
Deboutte, Dirk
TI Sexual Behavior in Male Adolescents and Young Adults with Autism
Spectrum Disorder and Borderline/Mild Mental Retardation
SO SEXUALITY AND DISABILITY
LA English
DT Article
DE Autism; Sexuality; Mild mental retardation; Borderline mental
retardation; Belgium
ID GENDER IDENTITY DISORDER; PARENTAL PERSPECTIVE; ATTITUDES; KNOWLEDGE
AB Group home caregivers of 20 institutionalized, male adolescents and young adults with Autistic Disorder (AD) and Borderline/Mild Mental Retardation (MR) and of 19 institutionalized, male adolescents and young adults with Borderline/Mild MR, without AD were interviewed with the Interview Sexuality Autism-Revised (ISA-R). Overall the individuals with AD were not significantly less sexually active than the individuals with MR. Masturbation was common in both groups. Individuals with MR had significantly more experience with relationships. No difference was found in the presence of inappropriate behavior. No difference was found in sexual orientation. Some deviant sexual behaviors (stereotyped sexual interests; sensory fascinations with a sexual connotation; paraphilia) were present in the group with AD, but not in the group with MR. A difference seemed to exist in the nature of sexual problems in the individuals with AD and MR, problems in individuals with AD being more related to an obsessive quality of the sexual behavior.
C1 [Hellemans, Hans; Deboutte, Dirk] Univ Ctr Child & Adolescent Psychiat Antwerp, Collaborat Antwerp Psychiat Res Inst, Antwerp, Belgium.
[Roeyers, Herbert; Leplae, Wouter; Dewaele, Tine] Univ Ghent, Dept Expt Clin & Hlth Psychol, B-9000 Ghent, Belgium.
RP Hellemans, H (reprint author), Univ Ctr Child & Adolescent Psychiat Antwerp, Collaborat Antwerp Psychiat Res Inst, Antwerp, Belgium.
EM Hans.Hellemans@zna.be
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NR 23
TC 7
Z9 7
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0146-1044
J9 SEX DISABIL
JI Sex. Disabil.
PD JUN
PY 2010
VL 28
IS 2
BP 93
EP 104
DI 10.1007/s11195-009-9145-9
PG 12
WC Rehabilitation
SC Rehabilitation
GA 593JM
UT WOS:000277450000003
ER
PT J
AU Bearman, P
AF Bearman, Peter
TI Just-so Stories: Vaccines, Autism, and the Single-bullet Disorder
SO SOCIAL PSYCHOLOGY QUARTERLY
LA English
DT Editorial Material
ID MEASLES; ASSOCIATION
C1 Columbia Univ, New York, NY 10027 USA.
RP Bearman, P (reprint author), Columbia Univ, New York, NY 10027 USA.
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NR 13
TC 4
Z9 4
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0190-2725
J9 SOC PSYCHOL QUART
JI Soc. Psychol. Q.
PD JUN
PY 2010
VL 73
IS 2
BP 112
EP 115
DI 10.1177/0190272510371672
PG 4
WC Psychology, Social
SC Psychology
GA 602CN
UT WOS:000278116000002
ER
PT J
AU Mak, WWS
Kwok, YTY
AF Mak, Winnie W. S.
Kwok, Yvonne T. Y.
TI Internalization of stigma for parents of children with autism spectrum
disorder in Hong Kong
SO SOCIAL SCIENCE & MEDICINE
LA English
DT Article
DE Hong Kong; Affiliate stigma; Attribution model; Social support; Parents;
Autism spectrum disorder; Children; China
ID PERCEIVED SOCIAL SUPPORT; MENTAL-ILLNESS; SELF-STIGMA; CHALLENGING
BEHAVIOR; INTELLECTUAL DISABILITIES; PSYCHOLOGICAL DISTRESS; ATTRIBUTION
MODEL; COURTESY STIGMA; FAMILY; PEOPLE
AB An attribution model was tested to explain the internalization of stigma among parents of children with Autism Spectrum Disorder (ASD). In the model, the internalization paths from courtesy stigma to affiliate stigma and the impact of three types of social support on affiliate stigma and psychological well-being were examined. The study was conducted in Hong Kong, China: one hundred and eighty-eight parents of children with ASD were recruited to complete the questionnaire. The model showed excellent fit to the data. Path analysis suggested three possible paths of internalizing courtesy stigma, including the direct path to affiliate stigma, through perceived controllability, or through perceived responsibility and self-blame. Support from family, significant others, friends, or professionals was found to be related to affiliate stigma and psychological well-being differentially. The internalization of stigma among parents of ASD children was severe. The path model sheds light on possible ways to reduce stigma in future services. (C) 2010 Elsevier Ltd. All rights reserved.
C1 [Mak, Winnie W. S.; Kwok, Yvonne T. Y.] Chinese Univ Hong Kong, Dept Psychol, Shatin, Hong Kong, Peoples R China.
RP Mak, WWS (reprint author), Chinese Univ Hong Kong, Dept Psychol, Shatin, Hong Kong, Peoples R China.
EM wwsmak@psy.cuhk.edu.hk
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NR 67
TC 24
Z9 24
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0277-9536
J9 SOC SCI MED
JI Soc. Sci. Med.
PD JUN
PY 2010
VL 70
IS 12
BP 2045
EP 2051
DI 10.1016/j.socscimed.2010.02.023
PG 7
WC Public, Environmental & Occupational Health; Social Sciences, Biomedical
SC Public, Environmental & Occupational Health; Biomedical Social Sciences
GA 608HL
UT WOS:000278574300024
PM 20362379
ER
PT J
AU Seso-Simic, D
Sedmak, G
Hof, PR
Simic, G
AF Seso-Simic, Durdica
Sedmak, Goran
Hof, Patrick R.
Simic, Goran
TI RECENT ADVANCES IN THE NEUROBIOLOGY OF ATTACHMENT BEHAVIOR
SO TRANSLATIONAL NEUROSCIENCE
LA English
DT Article
DE Aggressiveness; Attachment behavior; Autism; Dopamine; Emotional
development Motivation; Oxytocin; Mirror neurons; Parental bonding;
Psychopathology
ID HUMAN ORBITOFRONTAL CORTEX; PLASMA OXYTOCIN LEVELS; MIRROR-NEURON
SYSTEM; FEMALE PRAIRIE VOLES; MATERNAL-BEHAVIOR; FUNCTIONAL
NEUROANATOMY; DOPAMINE TRANSPORTER; MESOLIMBIC DOPAMINE; SPEECH
PRODUCTION; SOCIAL-BEHAVIOR
AB In a biological sense an individual's life is all about survival and reproduction. Beside the selection of a mate, the mutual commitment of a parent to sustain an infant through a period of dependency is amongst the most important aspects of natural selection. Here we review how the highly conserved circuitry of key midbrain and hypothalamic structures, and limbic and frontal cortical regions support these processes, and at the same time are involved in shaping the offspring's emotional development and behavior. Many recent studies provided new findings on how attachment behavior and parental bonding is promoted and maintained through genetic and epigenetic influences on synaptic plasticity of mirror neurons and various neuropeptide systems, particularly oxytocinergic, and how these systems serve to link social cues to the brain reward system. Most of this evidence suggests that stress, early parental deprivation and lack of care during the postnatal period leads to profound and lasting changes in the attachment pattern and motivational development with consequent increased vulnerability of the mesocortical and mesolimbic dopamine-associated reward reinforcement pathways to psychosocial stressors, abuse of stimulants and psychopathology later in life.
C1 [Seso-Simic, Durdica] Zagreb E Med Ctr, Dept Paediat, Zagreb, Croatia.
[Sedmak, Goran; Simic, Goran] Univ Zagreb, Sch Med, Croatian Inst Brain Res, Dept Neurosci, Zagreb 41001, Croatia.
[Hof, Patrick R.] Mt Sinai Sch Med, Dept Neurosci, New York, NY USA.
RP Seso-Simic, D (reprint author), Zagreb E Med Ctr, Dept Paediat, Zagreb, Croatia.
EM gsimic@hiim.hr
RI Simic, Goran/A-9262-2013
OI Simic, Goran/0000-0002-6339-9261
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NR 104
TC 0
Z9 0
PU VERSITA
PI WARSAW
PA SOLIPSKA 14A-1, 02-482 WARSAW, POLAND
SN 2081-3856
J9 TRANSL NEUROSCI
JI Transl. Neurosci.
PD JUN
PY 2010
VL 1
IS 2
BP 148
EP 159
DI 10.2478/v10134-010-0020-0
PG 12
WC Neurosciences
SC Neurosciences & Neurology
GA V20PY
UT WOS:000208153100008
ER
PT J
AU Baruth, JM
Casanova, MF
Sears, L
Sokhadze, E
AF Baruth, Joshua M.
Casanova, Manuel F.
Sears, Lonnie
Sokhadze, Estate
TI EARLY-STAGE VISUAL PROCESSING ABNORMALITIES IN HIGH-FUNCTIONING AUTISM
SPECTRUM DISORDER (ASD)
SO TRANSLATIONAL NEUROSCIENCE
LA English
DT Article
DE Autism; Event-related potentials; EEG; Visual processing; Evoked
potentials
AB It has been reported that individuals with autism spectrum disorder (ASD) have abnormal responses to the sensory environment. For these individuals sensory overload can impair functioning, raise physiological stress, and adversely affect social interaction. Early-stage (i.e. within 200 ms of stimulus onset) auditory processing abnormalities have been widely examined in ASD using event-related potentials (ERP), while ERP studies investigating early-stage visual processing in ASD are less frequent. We wanted to test the hypothesis of early-stage visual processing abnormalities in ASD by investigating ERPs elicited in a visual oddball task using illusory figures. Our results indicate that individuals with ASD have abnormally large cortical responses to task irrelevant stimuli over both parieto-occipital and frontal regions-of-interest (ROI) during early stages of visual processing compared to the control group. Furthermore, ASD patients showed signs of an overall disruption in stimulus discrimination, and had a significantly higher rate of motor response errors.
C1 [Baruth, Joshua M.; Casanova, Manuel F.] Univ Louisville, Sch Med, Dept Anat Sci & Neurobiol, Louisville, KY 40202 USA.
[Casanova, Manuel F.; Sokhadze, Estate] Univ Louisville, Sch Med, Dept Psychiat & Behav Sci, Louisville, KY 40202 USA.
[Sears, Lonnie] Univ Louisville, Sch Med, Dept Pediat, Louisville, KY 40202 USA.
RP Baruth, JM (reprint author), Univ Louisville, Sch Med, Dept Anat Sci & Neurobiol, Louisville, KY 40202 USA.
EM jmbaru01@louisville.edu
FU NIH [R01 MH86784, R01 MH88893]
FX Funding for this work was provided by NIH grants R01 MH86784 (MFC and
ES) and R01 MH88893 (MFC).
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NR 77
TC 9
Z9 9
PU VERSITA
PI WARSAW
PA SOLIPSKA 14A-1, 02-482 WARSAW, POLAND
SN 2081-3856
J9 TRANSL NEUROSCI
JI Transl. Neurosci.
PD JUN
PY 2010
VL 1
IS 2
BP 177
EP 187
DI 10.2478/v10134-010-0024-9
PG 11
WC Neurosciences
SC Neurosciences & Neurology
GA V20PY
UT WOS:000208153100011
ER
PT J
AU Korkmaz, B
AF Korkmaz, Baris
TI Autism: clinical and neurobiological features, early diagnosis,
treatment and some current developments
SO TURK PEDIATRI ARSIVI-TURKISH ARCHIVES OF PEDIATRICS
LA Turkish
DT Article
DE Autism; clinical features; early diagnosis; neurobiological features;
treatment
ID SPECTRUM DISORDERS; INFANTILE-AUTISM; CHILDREN; BRAIN; PREVALENCE;
CEREBELLUM; GENETICS; BEHAVIOR; AMYGDALA; NEURONS
AB Aim: The aim of this study is to review the studies about clinical and neurobiological features, early diagnosis and treatment of autism.
Material and Method: A computerized literature search was conducted using PubMed to retrieve studies about clinical and neurobiological features, early diagnosis and treatment of autism in addition to many references given to the textbooks.
Results: Autism is a neurobiological syndrome which has many subtypes through different mechanisms. The severity and the profile of clinical presentation depend on the degree and pervasiveness of involvement of overlapping neuroanatomical circuits. Among the clinical signs are impairment in social interaction and communication and restricted repetitive and stereotyped patterns of behavior, interests, and activities, sensory and behavioral disturbances.
Conclusions: There is no cure for autism and it is a lifelong disorder. Early diagnosis and beginning of early and appropriate educational intervention may improve adaptive skills. (Turk Arch Ped 2010; 45: 80(th) Year: 37-44)
C1 Istanbul Univ, Cerrahpasa Tip Fak, Norol Anabilim Dali, Istanbul, Turkey.
RP Korkmaz, B (reprint author), Istanbul Univ, Cerrahpasa Tip Fak, Norol Anabilim Dali, Istanbul, Turkey.
EM bkorkmaz@istanbul.edu.tr
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NR 70
TC 0
Z9 0
PU GALENOS YAYINCILIK
PI FINDIKZADE
PA MOLLA GURANI CAD 22-2, FINDIKZADE, ISTANBUL 34093, TURKEY
SN 1306-0015
J9 TURK PEDIATR ARSIVI
JI Turk Pediatr. Ars.
PD JUN
PY 2010
VL 45
SU S
BP 37
EP 44
PG 8
WC Pediatrics
SC Pediatrics
GA 599UQ
UT WOS:000277939600010
ER
PT J
AU Thompson, T
AF Thompson, Tok
TI The Ape That Captured Time Folklore, Narrative, and the Human-Animal
Divide
SO WESTERN FOLKLORE
LA English
DT Article
DE narrative; evolution; storytelling; play; animal language
ID EPISODIC MEMORY; RHESUS-MONKEYS; EVOLUTION; LANGUAGE; CHIMPANZEES;
CHILDREN; AUTISM; STORIES; FACULTY; CALLS
AB Recent advances in animal studies have documented the widespread use of learned, symbolic communication in the animal kingdom. Meanwhile, Mechling (1989) has argued that folklore, as shared learned traditions, also exists in non-human animals. Considering that many scholars believe humans are unique in our ability to tell stories, this schism between human and animal, the story and other folklore, has a great deal to tell us about the outlines and origins of humanity. This article seeks to integrate arguments from linguistics, archaeology, primatology, folklore, and cognitive science from evolutionary perspectives.
C1 Univ So Calif, Dept Anthropol, Los Angeles, CA 90089 USA.
RP Thompson, T (reprint author), Univ So Calif, Dept Anthropol, Los Angeles, CA 90089 USA.
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NR 85
TC 1
Z9 1
PU CALIFORNIA FOLKLORE SOC
PI POMONA
PA WESTERN FOLKLORE DEPT OF ENGL/FOREIGN LANGUAGES 3801 W.TEMPLE AVENUE,
POMONA, CA 91768-4010 USA
SN 0043-373X
J9 WESTERN FOLKLORE
JI West. Folk.
PD SUM-FAL
PY 2010
VL 69
IS 3-4
BP 395
EP 420
PG 26
WC Folklore
SC Arts & Humanities - Other Topics
GA 696KB
UT WOS:000285439200006
ER
PT J
AU Grinter, EJ
Maybery, MT
Badcock, DR
AF Grinter, Emma J.
Maybery, Murray T.
Badcock, David R.
TI Vision in developmental disorders: Is there a dorsal stream deficit?
SO BRAIN RESEARCH BULLETIN
LA English
DT Review
DE Vision; Dorsal stream; Local and global processing; Developmental
disorders; Dyslexia; Autism; Dyspraxia; William's syndrome; Fragile X
syndrome
ID FRAGILE-X-SYNDROME; AUTISM SPECTRUM DISORDER; GLOBAL MOTION PERCEPTION;
PRIMARY VISUAL-CORTEX; SCHOOL-AGE-CHILDREN; WILLIAMS-SYNDROME; CONTRAST
SENSITIVITY; OPTIC FLOW; VISIBLE PERSISTENCE; READING-DISABILITY
AB The main aim of this review is to evaluate the proposal that several developmental disorders affecting vision share an impairment of the dorsal visual stream. First, the current definitions and common measurement approaches used to assess differences in both local and global functioning within the visual system are considered. Next, studies assessing local and global processing in the dorsal and ventral visual pathways are reviewed for five developmental conditions for which early to mid level visual abilities have been assessed: developmental dyslexia, autism spectrum disorders, developmental dyspraxia. Williams syndrome and Fragile X syndrome. The reviewed evidence is broadly consistent with the idea that the dorsal visual stream is affected in developmental disorders. However, the potential for a unique profile of visual abilities that distinguish some of the conditions is posited, given that for some of these disorders ventral stream deficits have also been found. We conclude with ideas regarding future directions for the study of visual perception in children with developmental disorders using psychophysical measures. (C) 2010 Elsevier Inc. All rights reserved.
C1 [Grinter, Emma J.; Maybery, Murray T.; Badcock, David R.] Univ Western Australia, Sch Psychol, Perth, WA 6008, Australia.
RP Grinter, EJ (reprint author), Univ Western Australia, Sch Psychol, 35 Stirling Highway, Perth, WA 6008, Australia.
EM emmagrinter@graduate.uwa.edu.au
RI Badcock, David/A-4913-2008; Maybery, Murray/H-5390-2014
OI Badcock, David/0000-0002-4517-435X;
FU NHMRC Project [403942]
FX This research was supported by NH&MRC Project Grant 403942 awarded to
M.T. Maybery, D.R. Badcock, J.C. Badcock, and E. Pellicano.
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NR 182
TC 31
Z9 31
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0361-9230
EI 1873-2747
J9 BRAIN RES BULL
JI Brain Res. Bull.
PD MAY 31
PY 2010
VL 82
IS 3-4
BP 147
EP 160
DI 10.1016/j.brainresbull.2010.02.016
PG 14
WC Neurosciences
SC Neurosciences & Neurology
GA 626NM
UT WOS:000279972700001
PM 20211706
ER
PT J
AU Wan, CY
Demaine, K
Zipse, L
Norton, A
Schlaug, G
AF Wan, Catherine Y.
Demaine, Krystal
Zipse, Lauryn
Norton, Andrea
Schlaug, Gottfried
TI From music making to speaking: Engaging the mirror neuron system in
autism
SO BRAIN RESEARCH BULLETIN
LA English
DT Review
DE Autism; Music; Language; Brain; Mirror neuron system; Auditory-motor
mapping training
ID MELODIC INTONATION THERAPY; SPECTRUM DISORDERS; SPEECH PRODUCTION;
PREMOTOR CORTEX; MOTOR SYSTEM; PROFESSIONAL PIANISTS; ACTION
RECOGNITION; BROCAS APHASIA; ABSOLUTE PITCH; DOWN-SYNDROME
AB Individuals with autism show impairments in emotional tuning, social interactions and communication. These are functions that have been attributed to the putative human mirror neuron system (MNS), which contains neurons that respond to the actions of self and others. It has been proposed that a dysfunction of that system underlies some of the characteristics of autism. Here, we review behavioral and imaging studies that implicate the MNS (or a brain network with similar functions) in sensory-motor integration and speech representation, and review data supporting the hypothesis that MNS activity could be abnormal in autism. In addition, we propose that an intervention designed to engage brain regions that overlap with the MNS may have significant clinical potential. We argue that this engagement could be achieved through forms of music making. Music making with others (e.g., playing instruments or singing) is a multi-modal activity that has been shown to engage brain regions that largely overlap with the human MNS. Furthermore, many children with autism thoroughly enjoy participating in musical activities. Such activities may enhance their ability to focus and interact with others, thereby fostering the development of communication and social skills. Thus, interventions incorporating methods of music making may offer a promising approach for facilitating expressive language in otherwise nonverbal children with autism. (C) 2010 Elsevier Inc. All rights reserved.
C1 [Wan, Catherine Y.; Demaine, Krystal; Zipse, Lauryn; Norton, Andrea; Schlaug, Gottfried] Beth Israel Deaconess Med Ctr, Music & Neuroimaging Lab, Dept Neurol, Boston, MA 02215 USA.
[Wan, Catherine Y.; Demaine, Krystal; Zipse, Lauryn; Norton, Andrea; Schlaug, Gottfried] Harvard Univ, Sch Med, Boston, MA 02215 USA.
[Zipse, Lauryn] MGH Inst Hlth Profess, Dept Commun Sci & Disorders, Boston, MA 02129 USA.
RP Schlaug, G (reprint author), Beth Israel Deaconess Med Ctr, Music & Neuroimaging Lab, Dept Neurol, 330 Brookline Ave, Boston, MA 02215 USA.
EM gschlaug@bidmc.harvard.edu
FU Nancy Lurie Marks Family Foundation
FX We sincerely thank the Nancy Lurie Marks Family Foundation for their
support.
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NR 120
TC 23
Z9 23
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0361-9230
J9 BRAIN RES BULL
JI Brain Res. Bull.
PD MAY 31
PY 2010
VL 82
IS 3-4
BP 161
EP 168
DI 10.1016/j.brainresbull.2010.04.010
PG 8
WC Neurosciences
SC Neurosciences & Neurology
GA 626NM
UT WOS:000279972700002
PM 20433906
ER
PT J
AU Wachtel, LE
Hermida, A
Dhossche, DM
AF Wachtel, Lee E.
Hermida, Adriana
Dhossche, Dirk M.
TI Maintenance electroconvulsive therapy in autistic catatonia: A case
series review
SO PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
LA English
DT Review
DE Autism; Catatonia; Electroconvulsive therapy; GABA
ID SPECTRUM DISORDERS; ECT; CONTINUATION; ADOLESCENCE; SCHIZOPHRENIA;
INDIVIDUALS; CHILDHOOD
AB The usage of electroconvulsive therapy for the acute resolution of catatonia in autistic children and adults is a novel area that has received increased attention over the past few years. Reported length of the acute ECT course varies among these patients, and there is no current literature on maintenance ECT in autism. The maintenance ECT courses of three patients with autism who developed catatonia are presented. Clinical, research, legal, and administrative implications for ECT treatment in this special population are discussed. (C) 2010 Elsevier Inc. All rights reserved.
C1 [Wachtel, Lee E.] Johns Hopkins Sch Med, Dept Psychiat, Kennedy Krieger Inst, Baltimore, MD 21205 USA.
[Hermida, Adriana] Emory Univ, Sch Med, Dept Psychiat & Behav Sci, Atlanta, GA 30322 USA.
[Dhossche, Dirk M.] Univ Mississippi, Med Ctr, Dept Psychiat, Jackson, MS 39216 USA.
RP Wachtel, LE (reprint author), Johns Hopkins Sch Med, Dept Psychiat, Kennedy Krieger Inst, 707 N Broadway St,Rm 232, Baltimore, MD 21205 USA.
EM wachtel@kennedykrieger.org
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NR 78
TC 17
Z9 17
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0278-5846
J9 PROG NEURO-PSYCHOPH
JI Prog. Neuro-Psychopharmacol. Biol. Psychiatry
PD MAY 30
PY 2010
VL 34
IS 4
BP 581
EP 587
DI 10.1016/j.pnpbp.2010.03.012
PG 7
WC Clinical Neurology; Neurosciences; Pharmacology & Pharmacy; Psychiatry
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA 612GV
UT WOS:000278885700002
PM 20298732
ER
PT J
AU Emanuele, E
Boso, M
Brondino, N
Pietra, S
Barale, F
di Nemi, SU
Politi, P
AF Emanuele, Enzo
Boso, Marianna
Brondino, Natascia
Pietra, Stefania
Barale, Francesco
di Nemi, Stefania Ucelli
Politi, Pierluigi
TI Increased serum levels of high mobility group box 1 protein in patients
with autistic disorder
SO PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
LA English
DT Review
DE Autism spectrum disorder; High mobility group box 1; Inflammation;
Social interaction
ID AGE-RAGE; HMGB1; RECEPTOR; BRAIN; NEUROINFLAMMATION; DYSFUNCTION;
ASTROCYTES; ACTIVATION; RELEASE; ROLES
AB Background: High mobility group box 1 (HMGB1) is a highly conserved, ubiquitous protein that functions as an activator for inducing the immune response and can be released from neurons after glutamate excitotoxicity. The objective of the present study was to measure serum levels of HMGB1 in patients with autistic disorder and to study their relationship with clinical characteristics.
Methods: We enrolled 22 adult patients with autistic disorder (mean age: 28.1 +/- 7.7 years) and 28 age- and gender-matched healthy controls (mean age: 28.7 +/- 8.1 years). Serum levels of HMGB1 were measured by enzyme-linked immunosorbent assay (ELISA).
Results: Compared with healthy subjects, serum levels of HMGB1 were significantly higher in patients with autistic disorder (10.8 +/- 2.6 ng/mL versus 5.6 +/- 2.5 ng/mL, respectively, P<0.001). After adjustment for potential confounders, serum HMGB1 levels were independently associated with their domain A scores in the Autism Diagnostic Interview-Revised, which reflects their impairments in social interaction.
Conclusions: These results suggest that HMGB1 levels may be affected in autistic disorder. Increased HMGB1 may be a biological correlate of the impaired reciprocal social interactions in this neurodevelopmental disorder. (C) 2010 Elsevier Inc. All rights reserved.
C1 [Emanuele, Enzo; Boso, Marianna; Brondino, Natascia; Pietra, Stefania; Barale, Francesco; di Nemi, Stefania Ucelli; Politi, Pierluigi] Univ Pavia, Sect Psychiat, Dept Hlth Sci, I-27100 Pavia, Italy.
RP Emanuele, E (reprint author), Univ Pavia, Sect Psychiat, Dept Hlth Sci, Via Bassi 21, I-27100 Pavia, Italy.
EM enzo.sem@libero.it
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NR 29
TC 13
Z9 13
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0278-5846
J9 PROG NEURO-PSYCHOPH
JI Prog. Neuro-Psychopharmacol. Biol. Psychiatry
PD MAY 30
PY 2010
VL 34
IS 4
BP 681
EP 683
DI 10.1016/j.pnpbp.2010.03.020
PG 3
WC Clinical Neurology; Neurosciences; Pharmacology & Pharmacy; Psychiatry
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA 612GV
UT WOS:000278885700018
PM 20302902
ER
PT J
AU Park, J
Willmott, M
Vetuz, G
Toye, C
Kirley, A
Hawi, Z
Brookes, KJ
Gill, M
Kent, L
AF Park, J.
Willmott, M.
Vetuz, G.
Toye, C.
Kirley, A.
Hawi, Z.
Brookes, K. J.
Gill, M.
Kent, L.
TI Evidence that genetic variation in the oxytocin receptor (OXTR) gene
influences social cognition in ADHD
SO PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
LA English
DT Review
DE ADHD; Association; Human post-mortem brain tissue; OXTR; Social
cognition
ID ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; PERVASIVE DEVELOPMENTAL
DISORDERS; AUTISTIC TRAITS; KNOCKOUT MOUSE; GENOME-WIDE; TWIN SAMPLE;
HUMAN BRAIN; VASOPRESSIN; BEHAVIOR; AMYGDALA
AB Some children with ADHD also have social and communication difficulties similar to those seen in children with autistic spectrum disorders and this may be due to shared genetic liability. As the oxytocin receptor (OXTR) gene has been implicated in social cognition and autistic spectrum disorders, this study investigated whether OXTR polymorphisms previously implicated in autism were associated with ADHD and whether they influenced OXTR mRNA expression in 27 normal human amygdala brain samples. The family-based association sample consisted of 450 DSM-IV diagnosed ADHD probands and their parents. Although there was no association with the ADHD phenotype, an association with social cognitive impairments in a subset of the ADHD probands (N = 112) was found for SNP rs53576 (F = 5.24, p = 0.007) with post-hoc tests demonstrating that the AA genotype was associated with better social ability compared to the AG genotype. Additionally, significant association was also found for rs13316193 (F = 3.09, p = 0.05) with post-hoc tests demonstrating that the CC genotype was significantly associated with poorer social ability than the TT genotype. No significant association between genotype and OXTR mRNA expression was found. This study supports previous evidence that the OXTR gene is implicated in social cognition. (C) 2010 Elsevier Inc. All rights reserved.
C1 [Park, J.; Willmott, M.; Vetuz, G.; Toye, C.; Brookes, K. J.; Kent, L.] Univ St Andrews, Bute Med Sch, St Andrews KY16 9TS, Fife, Scotland.
[Kirley, A.; Hawi, Z.; Gill, M.] St James Hosp, Dept Psychiat, Trinity Ctr Hlth Sci, Dublin 8, Ireland.
RP Kent, L (reprint author), Univ St Andrews, Bute Med Sch, St Andrews KY16 9TS, Fife, Scotland.
EM lsk8@st-andrews.ac.uk
FU Wellcome Trust; Health Research Board (Dublin)
FX The sample collection for this project was partly funded by the Wellcome
Trust (LK) and with generous support from the Health Research Board
(Dublin) (ZH and EB). The authors declare that there are no competing
interests. We would like to thank Dr. Robert Walker from the Edinburgh
MRC Sudden Death Brain and Tissue Bank for his assistance and all the
families involved in the study for their participation.
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NR 46
TC 29
Z9 29
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0278-5846
J9 PROG NEURO-PSYCHOPH
JI Prog. Neuro-Psychopharmacol. Biol. Psychiatry
PD MAY 30
PY 2010
VL 34
IS 4
BP 697
EP 702
DI 10.1016/j.pnpbp.2010.03.029
PG 6
WC Clinical Neurology; Neurosciences; Pharmacology & Pharmacy; Psychiatry
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA 612GV
UT WOS:000278885700022
PM 20347913
ER
PT J
AU Baron, J
AF Baron, Joanna
TI Autism accuracy
SO NEW SCIENTIST
LA English
DT Letter
NR 0
TC 0
Z9 0
PU REED BUSINESS INFORMATION LTD
PI SUTTON
PA QUADRANT HOUSE THE QUADRANT, SUTTON SM2 5AS, SURREY, ENGLAND
SN 0262-4079
J9 NEW SCI
JI New Sci.
PD MAY 29
PY 2010
VL 206
IS 2762
BP 28
EP 28
PG 1
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 603MZ
UT WOS:000278214000017
ER
PT J
AU Barry, B
AF Barry, Brian
TI Autism accuracy
SO NEW SCIENTIST
LA English
DT Letter
NR 0
TC 0
Z9 0
PU REED BUSINESS INFORMATION LTD
PI SUTTON
PA QUADRANT HOUSE THE QUADRANT, SUTTON SM2 5AS, SURREY, ENGLAND
SN 0262-4079
J9 NEW SCI
JI New Sci.
PD MAY 29
PY 2010
VL 206
IS 2762
BP 28
EP 28
PG 1
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 603MZ
UT WOS:000278214000018
ER
PT J
AU Dawson, M
AF Dawson, Michelle
TI Autism accuracy
SO NEW SCIENTIST
LA English
DT Letter
C1 Univ Montreal, Ctr Excellence Troubles Envahissants Dev, Montreal, PQ, Canada.
RP Dawson, M (reprint author), Univ Montreal, Ctr Excellence Troubles Envahissants Dev, Montreal, PQ, Canada.
NR 0
TC 0
Z9 0
PU REED BUSINESS INFORMATION LTD
PI SUTTON
PA QUADRANT HOUSE THE QUADRANT, SUTTON SM2 5AS, SURREY, ENGLAND
SN 0262-4079
J9 NEW SCI
JI New Sci.
PD MAY 29
PY 2010
VL 206
IS 2762
BP 28
EP 28
PG 1
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 603MZ
UT WOS:000278214000016
ER
PT J
AU Keller, E
AF Keller, E.
TI The Grischuna autism experience: A retrospective study over the last 10
years
SO SWISS MEDICAL WEEKLY
LA English
DT Meeting Abstract
NR 0
TC 0
Z9 0
PU E M H SWISS MEDICAL PUBLISHERS LTD
PI MUTTENZ
PA FARNSBURGERSTR 8, CH-4132 MUTTENZ, SWITZERLAND
SN 1424-7860
J9 SWISS MED WKLY
JI Swiss Med. Wkly.
PD MAY 29
PY 2010
VL 140
IS 21-22
SU 180
BP 29S
EP 29S
PG 1
WC Medicine, General & Internal
SC General & Internal Medicine
GA 610NI
UT WOS:000278739300114
ER
PT J
AU Bruining, H
de Sonneville, L
Swaab, H
de Jonge, M
Kas, M
van Engeland, H
Vorstman, J
AF Bruining, Hilgo
de Sonneville, Leo
Swaab, Hanna
de Jonge, Maretha
Kas, Martien
van Engeland, Herman
Vorstman, Jacob
TI Dissecting the Clinical Heterogeneity of Autism Spectrum Disorders
through Defined Genotypes
SO PLOS ONE
LA English
DT Article
ID DIAGNOSTIC OBSERVATION SCHEDULE; KLINEFELTER-SYNDROME; RETT-SYNDROME;
22Q11.2 DELETION; CHILDREN; INTERVIEW; ADOLESCENTS; PHENOTYPES;
MUTATIONS; GENETICS
AB Background: The etiology of autism spectrum disorders (ASD) is largely determined by different genetic factors of variable impact. This genetic heterogeneity could be a factor to explain the clinical heterogeneity of autism spectrum disorders. Here, a first attempt is made to assess whether genetically more homogeneous ASD groups are associated with decreased phenotypic heterogeneity with respect to their autistic symptom profile.
Methodology: The autistic phenotypes of ASD subjects with 22q11 deletion syndrome (22q11DS) and ASD subjects with Klinefelter Syndrome (KS) were statistically compared to the symptom profile of a large (genetically) heterogeneous ASD sample. Autism diagnostic interview-revised (ADI-R) variables were entered in different statistical analyses to assess differences in symptom homogeneity and the feasibility of discrimination of group-specific ASD-symptom profiles.
Principal Findings: The results showed substantially higher symptom homogeneity in both the genetic disorder ASD groups in comparison to the heterogeneous ASD sample. In addition, a robust discrimination between 22q11-ASD and KS-ASD and idiopathic ASD phenotypes was feasible on the basis of a reduced number of autistic scales and symptoms. The lack of overlap in discriminating subscales and symptoms between KS-ASD and 22q11DS-ASD suggests that their autistic symptom profiles cluster around different points in the total diagnostic space of profiles present in the general ASD population.
Conclusion: The findings of the current study indicate that the clinical heterogeneity of ASDs may be reduced when subgroups based on a specific genotype are extracted from the idiopathic ASD population. The current strategy involving the widely used ADI-R offers a relatively straightforward possibility for assessing genotype-phenotype ASD relationships. Reverse phenotype strategies are becoming more feasible, given the accumulating evidence for the existence of genetic variants of large effect in a substantial proportion of the ASD population.
C1 [Bruining, Hilgo; Swaab, Hanna; de Jonge, Maretha; van Engeland, Herman; Vorstman, Jacob] Univ Med Ctr Utrecht, Dept Children & Adolescent Psychiat, Rudolf Magnus Inst Neurosci, Utrecht, Netherlands.
[de Sonneville, Leo; Swaab, Hanna] Leiden Univ, Dept Clin Child & Adolescent Studies, Leiden, Netherlands.
[Kas, Martien] Univ Med Ctr Utrecht, Dept Neurosci & Pharmacol, Rudolf Magnus Inst Neurosci, Utrecht, Netherlands.
RP Bruining, H (reprint author), Univ Med Ctr Utrecht, Dept Children & Adolescent Psychiat, Rudolf Magnus Inst Neurosci, Utrecht, Netherlands.
EM h.bruining@Umcutrecht.nl
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NR 33
TC 30
Z9 30
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD MAY 28
PY 2010
VL 5
IS 5
AR e10887
DI 10.1371/journal.pone.0010887
PG 7
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 603QC
UT WOS:000278222100016
PM 20526357
ER
PT J
AU Shukla, DK
Keehn, B
Muller, RA
AF Shukla, Dinesh K.
Keehn, Brandon
Mueller, Ralph Axel
TI Regional homogeneity of fMRI time series in autism spectrum disorders
SO NEUROSCIENCE LETTERS
LA English
DT Article
DE Autism spectrum disorder; Functional MRI; Functional connectivity;
Regional homogeneity
ID ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; RESTING-STATE; FUNCTIONAL
CONNECTIVITY; CORTICAL CONNECTIVITY; SPATIAL ATTENTION; BRAIN;
ORGANIZATION; CORTEX; ABNORMALITIES; INDIVIDUALS
AB Functional magnetic resonance imaging (fMRI) and functional connectivity MRI (fcMRI) studies of autism spectrum disorders (ASD) have suggested atypical patterns of activation and long-distance connectivity for diverse tasks and networks in ASD. We explored the regional homogeneity (ReHo) approach in ASD, which is analogous to conventional fcMRI, but focuses on local connectivity. FMRI data of 26 children with ASD and 29 typically developing (TD) children were acquired during continuous task performance (visual search). Effects of motion and task were removed and Kendall's coefficient of concordance (KCC) was computed, based on the correlation of the blood oxygen level dependent (BOLD) time series for each voxel and its six nearest neighbors. ReHo was lower in the ASD than the TD group in superior parietal and anterior prefrontal regions. Inverse effects of greater ReHo in the ASD group were detected in lateral and medial temporal regions, predominantly in the right hemisphere. Our findings suggest that ReHo is a sensitive measure for detecting cortical abnormalities in autism. However, impact of methodological factors (such as spatial resolution) on ReHo require further investigation. Published by Elsevier Ireland Ltd.
C1 [Shukla, Dinesh K.; Keehn, Brandon; Mueller, Ralph Axel] San Diego State Univ, Dept Psychol, Brain Dev Imaging Lab, San Diego, CA 92120 USA.
[Keehn, Brandon] Univ Calif, San Diego State Univ, San Diego Joint Doctoral Program Language & Commu, San Diego, CA USA.
[Mueller, Ralph Axel] Univ Calif San Diego, Dept Cognit Sci, San Diego, CA 92093 USA.
RP Muller, RA (reprint author), San Diego State Univ, Dept Psychol, Brain Dev Imaging Lab, 6363 Alvarado Ct,Suite 225E, San Diego, CA 92120 USA.
EM amueller@sciences.sdsu.edu
FU National Institutes of Health [R01-DC006155, R01-MH081023, 1T32
DC007361-03]
FX This study was supported by the National Institutes of Health,
R01-DC006155, R01-MH081023, and 1T32 DC007361-03 (BK). Thanks to the
children and families who participated, to Yufeng Zang, Chao-Gan Yan,
and Xiang-Yu Long for technical support, and to Patricia Shih for
comments on the manuscript.
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NR 50
TC 33
Z9 38
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
IRELAND
SN 0304-3940
J9 NEUROSCI LETT
JI Neurosci. Lett.
PD MAY 26
PY 2010
VL 476
IS 1
BP 46
EP 51
DI 10.1016/j.neulet.2010.03.080
PG 6
WC Neurosciences
SC Neurosciences & Neurology
GA 602WR
UT WOS:000278170200011
PM 20381584
ER
PT J
AU Ghosh, RP
Nikitina, T
Horowitz-Scherer, RA
Gierasch, LM
Uversky, VN
Hite, K
Hansen, JC
Woodcock, CL
AF Ghosh, Rajarshi P.
Nikitina, Tatiana
Horowitz-Scherer, Rachel A.
Gierasch, Lila M.
Uversky, Vladimir N.
Hite, Kristopher
Hansen, Jeffrey C.
Woodcock, Christopher L.
TI Unique Physical Properties and Interactions of the Domains of Methylated
DNA Binding Protein 2
SO BIOCHEMISTRY
LA English
DT Article
ID CIRCULAR-DICHROISM SPECTRA; RETT-SYNDROME; SECONDARY STRUCTURE;
TRANSCRIPTIONAL REPRESSION; DISORDERED PROTEINS; INTRINSIC DISORDER;
HUMAN MECP2; IN-VIVO; CPG; CHROMATIN
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C1 [Nikitina, Tatiana; Horowitz-Scherer, Rachel A.; Woodcock, Christopher L.] Univ Massachusetts, Dept Biol, Amherst, MA 01003 USA.
[Ghosh, Rajarshi P.; Gierasch, Lila M.; Woodcock, Christopher L.] Univ Massachusetts, Program Mol & Cellular Biol, Amherst, MA 01003 USA.
[Gierasch, Lila M.] Univ Massachusetts, Dept Biochem & Mol Biol, Amherst, MA 01003 USA.
[Uversky, Vladimir N.] Indiana Univ, Sch Med, Dept Biochem & Mol Biol, Inst Intrinsically Disordered Prot Res,Ctr Comput, Indianapolis, IN 46202 USA.
[Uversky, Vladimir N.] Russian Acad Sci, Inst Biol Instrumentat, Pushchino 142290, Moscow Region, Russia.
[Hite, Kristopher; Hansen, Jeffrey C.] Colorado State Univ, Dept Biochem & Mol Biol, Ft Collins, CO 80523 USA.
[Gierasch, Lila M.] Univ Massachusetts, Dept Chem, Amherst, MA 01003 USA.
RP Woodcock, CL (reprint author), Univ Massachusetts, Dept Biol, Amherst, MA 01003 USA.
EM chris@bio.umass.edu
RI Uversky, Vladimir/F-4515-2011
OI Uversky, Vladimir/0000-0002-4037-5857
FU National Institutes of Health (NIH) [GM070897, GM066834, GM027616,
OD945, LM007688, GM071714]; Russian Academy of Sciences; IUPUI
Signatures Center Initiative
FX Supported by National Institutes of Health (NIH) Grant GM070897 and the
International Rett Syndrome Foundation (C.L.W.); NIH Grant GM066834
(J.C.H.); NIH Grants GM027616 and OD945 (L.M.G.); and NIH Grants
LM007688 and GM071714, the program of the Russian Academy of Sciences
for "Molecular and Cellular Biology", and the IUPUI Signatures Center
Initiative (V.N.U.).
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NR 80
TC 31
Z9 34
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0006-2960
J9 BIOCHEMISTRY-US
JI Biochemistry
PD MAY 25
PY 2010
VL 49
IS 20
BP 4395
EP 4410
DI 10.1021/bi9019753
PG 16
WC Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA 595YD
UT WOS:000277649200011
PM 20405910
ER
PT J
AU Hall, GBC
Doyle, KAR
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Szatmari, Peter
TI Amygdala Engagement in Response to Subthreshold Presentations of Anxious
Face Stimuli in Adults with Autism Spectrum Disorders: Preliminary
Insights
SO PLOS ONE
LA English
DT Article
ID EMOTIONAL FACIAL EXPRESSIONS; PERVASIVE DEVELOPMENTAL DISORDERS; NEURAL
RESPONSES; FUNCTIONAL NEUROANATOMY; GAZE-FIXATION; BRAIN; FEAR;
INDIVIDUALS; MONKEY; INFORMATION
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C1 [Hall, Geoffrey B. C.; Doyle, Krissy A. R.; Goldberg, Jeremy; West, Dianne; Szatmari, Peter] McMaster Univ, Fac Hlth Sci, Dept Psychiat & Behav Neurosci, Hamilton, ON, Canada.
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RP Hall, GBC (reprint author), McMaster Univ, Fac Hlth Sci, Dept Psychiat & Behav Neurosci, Hamilton, ON, Canada.
EM hallg@mcmaster.ca
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NR 65
TC 13
Z9 13
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD MAY 25
PY 2010
VL 5
IS 5
AR e10804
DI 10.1371/journal.pone.0010804
PG 8
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 601CE
UT WOS:000278034800004
PM 20520836
ER
PT J
AU Sundaram, SK
Huq, AM
Wilson, BJ
Chugani, HT
AF Sundaram, Senthil K.
Huq, Ahm M.
Wilson, Benjamin J.
Chugani, Harry T.
TI Tourette syndrome is associated with recurrent exonic copy number
variants
SO NEUROLOGY
LA English
DT Article
ID AUTISM; SCHIZOPHRENIA; DISORDER; INHERITANCE; FAMILY; GENES; RISK
AB Background: Multiple rare copy number variants (CNVs) including genomic deletions and duplications play a prominent role in neurodevelopmental disorders such as mental retardation, autism, and schizophrenia, but have not been systematically studied in Tourette syndrome (TS).
Methods: We performed a genome-wide screening of single nucleotide polymorphism (SNP) genotyping microarray data to identify recurrent or de novo rare exonic CNVs in a case-control association study of patients with TS.
Results: We identified 5 exon-affecting rare CNVs that are either de novo or recurrent in 10 out of 111 patients with TS but were not found in 73 ethnically matched controls or in the entries of the Database of Genomic Variants (containing 21,178 CNVs at 6,558 loci). Three out of the 5 CNVs have been implicated previously by other studies in schizophrenia, autism, and attention-deficit hyperactivity disorder, suggesting that these CNVs produce a continuum of neuropsychiatric disturbances that manifest in different ways depending on other genetic, environmental, or stochastic factors.
Conclusions: Rare, recurrent exonic copy number variants are associated in a subset of patients with Tourette syndrome. Neurology (R) 2010; 74: 1583-1590
C1 [Sundaram, Senthil K.; Huq, Ahm M.; Wilson, Benjamin J.; Chugani, Harry T.] Wayne State Univ, Dept Pediat & Neurol, Detroit, MI USA.
RP Huq, AM (reprint author), Childrens Hosp Michigan, Div Neurol, 3901 Beaubien Blvd, Detroit, MI 48201 USA.
EM ahuq@med.wayne.edu
RI Sundaram, Senthil/B-3905-2013
OI Sundaram, Senthil/0000-0002-0382-0536
FU National Center for Research Resources, NIH [UL1 RR024139]; NIH (NICHD)
[1R01HD059817-01A1, R01HD05981701A1]; Festival of Trees; NIH (NINDS)
[R01 NS 34488]
FX Supported by the Clinical and Translational Science Award UL1 RR024139,
National Center for Research Resources, NIH.Dr. Sundaram receives
research support from the NIH (NICHD 1R01HD059817-01A1 [PI]). Dr. Huq
serves as an Associate Editor of MedLink Neurology and receives research
support from the NIH (NICHD 1R01HD059817-01A1 [Co-I]) and from Festival
of Trees. B.J. Wilson reports no disclosures. Dr. Chugani serves on the
editorial boards of Journal of Child Neurology, Journal of Pediatric
Neurology, Brain and Development, and Pediatric Neurology, and receives
research support from the NIH (NINDS R01 NS 34488 [PI] and NICHD
R01HD05981701A1[Co-I]).
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NR 20
TC 44
Z9 45
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0028-3878
J9 NEUROLOGY
JI Neurology
PD MAY 18
PY 2010
VL 74
IS 20
BP 1583
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PG 8
WC Clinical Neurology
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SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF
AMERICA
LA English
DT Editorial Material
ID HIGH-FUNCTIONING AUTISM; MATERNAL-BEHAVIOR; NEURAL CIRCUITRY; HUMANS;
FACES; TRUST; RATS; MIND
C1 NIMH, Neuropsychol Lab, NIH, Bethesda, MD 20892 USA.
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NR 20
TC 22
Z9 23
PU NATL ACAD SCIENCES
PI WASHINGTON
PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA
SN 0027-8424
J9 P NATL ACAD SCI USA
JI Proc. Natl. Acad. Sci. U. S. A.
PD MAY 18
PY 2010
VL 107
IS 20
BP 9033
EP 9034
DI 10.1073/pnas.1004892107
PG 2
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 598GH
UT WOS:000277822600005
PM 20448196
ER
PT J
AU Hoeft, F
Carter, JC
Lightbody, AA
Hazlett, HC
Piven, J
Reiss, AL
AF Hoeft, Fumiko
Carter, John C.
Lightbody, Amy A.
Hazlett, Heather Cody
Piven, Joseph
Reiss, Allan L.
TI Region-specific alterations in brain development in one- to
three-year-old boys with fragile X syndrome
SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF
AMERICA
LA English
DT Article
DE early childhood; longitudinal; MRI; voxel-based morphometry
ID MENTAL-RETARDATION SYNDROME; MOUSE MODEL; PROTEIN; BEHAVIOR; CORTEX;
SYNAPTOGENESIS; ABNORMALITIES; NEUROANATOMY; EXPRESSION; GROWTH
AB Longitudinal neuroimaging investigation of fragile X syndrome (FXS), the most common cause of inherited intellectual disability and autism, provides an opportunity to study the influence of a specific genetic factor on neurodevelopment in the living human brain. We examined voxel-wise gray and white matter volumes (GMV, WMV) over a 2-year period in 1- to 3-year-old boys with FXS (n = 41) and compared these findings to age-and developmentally matched controls (n = 28). We found enlarged GMV in the caudate, thalamus, and fusiform gyri and reduced GMV in the cerebellar vermis in FXS at both timepoints, suggesting early, possibly prenatal, genetically mediated alterations in neurodevelopment. In contrast, regions in which initial GMV was similar, followed by an altered growth trajectory leading to increased size in FXS, such as the orbital gyri, basal forebrain, and thalamus, suggests delayed or otherwise disrupted synaptic pruning occurring postnatally. WMV of striatal-prefrontal regions was greater in FXS compared with controls, and group differences became more exaggerated over time, indicating the possibility that such WM abnormalities are the result of primary FMRP-deficiency-related axonal pathology, as opposed to secondary connectional dysregulation between morphologically atypical brain structures. Our results indicate that structural abnormalities of different brain regions in FXS evolve differently over time reflecting time-dependent effects of FMRP deficiency and provide insight into their neuropathologic underpinnings. The creation of an early and accurate human brain phenotype for FXS in humans will significantly improve our capability to detect whether new disease-specific treatments can "rescue" the FXS phenotype in affected individuals.
C1 [Hoeft, Fumiko; Carter, John C.; Lightbody, Amy A.; Reiss, Allan L.] Stanford Univ, Sch Med, Ctr Interdisciplinary Brain Sci Res, Stanford, CA 94305 USA.
[Hazlett, Heather Cody; Piven, Joseph] Univ N Carolina, Carolina Inst Dev Disabil, Chapel Hill, NC 27514 USA.
RP Reiss, AL (reprint author), Stanford Univ, Sch Med, Ctr Interdisciplinary Brain Sci Res, Stanford, CA 94305 USA.
EM reiss@stanford.edu
FU Canel family fund; National Alliance for Research on Schizophrenia and
Depression Young Investigator Award, Stanford Child Health Spectrum;
National Institute of Child Health and Human Development [HD054720];
[MH64708-05]; [MH61696]; [HD03110-36]; [MH050047]
FX We sincerely thank all of the families who made this study possible. We
also thank Chad Chappell, MA; Nancy Garrett, BA; Michael Graves, MChe;
Cindy Hagan, BA; Cindy Johnston, MS; Judy Morrow, PhD; Robin Morris, BA;
Rachel Smith, BA; Arianna Martin, BA; Cristiana Vattuone, BA; Christa
Watson, BA; Anh Weber, PhD; Masanori Nagamine, MD/PhD; Kelly Chen, BS;
and Sweta Patnaik, MS who were involved in data collection and/or
processing. This study was funded by MH64708-05 (to A.L.R. and J.P.),
MH61696 (to J.P.), HD03110-36 (to J.P.), MH050047 (to A.L.R.), and the
Canel family fund, and F.H. was funded by National Alliance for Research
on Schizophrenia and Depression Young Investigator Award, Stanford Child
Health Spectrum, and National Institute of Child Health and Human
Development HD054720.
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NR 31
TC 47
Z9 48
PU NATL ACAD SCIENCES
PI WASHINGTON
PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA
SN 0027-8424
J9 P NATL ACAD SCI USA
JI Proc. Natl. Acad. Sci. U. S. A.
PD MAY 18
PY 2010
VL 107
IS 20
BP 9335
EP 9339
DI 10.1073/pnas.1002762107
PG 5
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 598GH
UT WOS:000277822600057
PM 20439717
ER
PT J
AU Schippers, MB
Roebroeck, A
Renken, R
Nanetti, L
Keysers, C
AF Schippers, Marleen B.
Roebroeck, Alard
Renken, Remco
Nanetti, Luca
Keysers, Christian
TI Mapping the information flow from one brain to another during gestural
communication
SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF
AMERICA
LA English
DT Article
DE Granger causality; mirror system; social interaction; theory of mind;
functional MRI
ID MIRROR-NEURON SYSTEM; SOCIAL COGNITION; ACTION RECOGNITION; FMRI;
SIMULATION; IMITATION; CORTEX; MIND; REPRESENTATIONS; MECHANISMS
AB Both the putative mirror neuron system (pMNS) and the ventral medial prefrontal cortex (vmPFC) are deemed important for social interaction: the pMNS because it supposedly "resonates" with the actions of others, the vmPFC because it is involved in mentalizing. Strictly speaking, the resonance property of the pMNS has never been investigated. Classical functional MRI experiments have only investigated whether pMNS regions augment their activity when an action is seen or executed. Resonance, however, entails more than only "going on and off together". Activity in the pMNS of an observer should continuously follow the more subtle changes over time in activity of the pMNS of the actor. Here we directly explore whether such resonance indeed occurs during continuous streams of actions. We let participants play the game of charades while we measured brain activity of both gesturer and guesser. We then applied a method to localize directed influences between the brains of the participants: between-brain Granger-causality mapping. Results show that a guesser's brain activity in regions involved in mentalizing and mirroring echoes the temporal structure of a gesturer's brain activity. This provides evidence for resonance theories and indicates a fine-grained temporal interplay between regions involved in motor planning and regions involved in thinking about the mental states of others. Furthermore, this method enables experiments to be more ecologically valid by providing the opportunity to leave social interaction unconstrained. This, in turn, would allow us to tap into the neural substrates of social deficits such as autism spectrum disorder.
C1 [Schippers, Marleen B.; Renken, Remco; Nanetti, Luca; Keysers, Christian] Univ Groningen, Univ Med Ctr Groningen, Social Brain Lab, Dept Neurosci, NL-9713 AW Groningen, Netherlands.
[Roebroeck, Alard] Univ Maastricht, Dept Cognit Neurosci, Fac Psychol, NL-6229 ER Maastricht, Netherlands.
[Keysers, Christian] Royal Netherlands Acad Arts & Sci KNAW, Social Brain Lab, Netherlands Inst Neurosci, NL-1105 BA Amsterdam, Netherlands.
RP Keysers, C (reprint author), Univ Groningen, Univ Med Ctr Groningen, Social Brain Lab, Dept Neurosci, NL-9713 AW Groningen, Netherlands.
EM c.keysers@nin.knaw.nl
RI Keysers, Christian/H-6251-2013
OI Keysers, Christian/0000-0002-2845-5467
FU Dutch Science Foundation (NWO); European Commission
FX We thank V. Gazzola and R. Goebel for help in designing the experiment
and the latter for providing BrainVoyager, and P. Toffanin, M. Spezio,
and D. Arnstein for critical comments on the manuscript. The research
was supported by a Vidi grant of the Dutch Science Foundation (NWO) and
a Marie Curie Excellence Grant of the European Commission (to C.K.).
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NR 45
TC 78
Z9 78
PU NATL ACAD SCIENCES
PI WASHINGTON
PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA
SN 0027-8424
J9 P NATL ACAD SCI USA
JI Proc. Natl. Acad. Sci. U. S. A.
PD MAY 18
PY 2010
VL 107
IS 20
BP 9388
EP 9393
DI 10.1073/pnas.1001791107
PG 6
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 598GH
UT WOS:000277822600066
PM 20439736
ER
PT J
AU Gamer, M
Zurowski, B
Buchel, C
AF Gamer, Matthias
Zurowski, Bartosz
Buechel, Christian
TI Different amygdala subregions mediate valence-related and attentional
effects of oxytocin in humans
SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF
AMERICA
LA English
DT Article
DE eyes; facial expression; functional neuroimaging; neuropeptides; social
perception
ID FACIAL EXPRESSIONS; SOCIAL-BEHAVIOR; IMPAIRED RECOGNITION; NEURAL
CIRCUITRY; FACES; AUTISM; BRAIN; GAZE; ACTIVATION; RESPONSES
AB The neuropeptide oxytocin enhances the processing of positive social stimuli and improves the capacity to effectively attend the eye region of conspecifics. To investigate the neural basis of these effects, we combined intranasal oxytocin administration with high-resolution functional magnetic resonance imaging in a unique emotion classification task. Emotional faces were briefly presented while controlling for the initial fixation, and measuring subsequent eye movements. Oxytocin had differential effects on the activity of specific amygdala subregions. On the one hand, it attenuated activation in lateral and dorsal regions of the anterior amygdala for fearful faces but enhanced activity for happy expressions, thus indicating a shift of the processing focus toward positive social stimuli. On the other hand, oxytocin increased the likelihood of reflexive gaze shifts toward the eye region irrespective of the depicted emotional expression. This gazing pattern was related to an increase of activity in the posterior amygdala and an enhanced functional coupling of this region to the superior colliculi. Thus, different behavioral effects of oxytocin seem to be closely related its specific modulatory influence on subregions within the human amygdala.
C1 [Gamer, Matthias; Zurowski, Bartosz; Buechel, Christian] Univ Med Ctr Hamburg Eppendorf, Dept Syst Neurosci, D-20246 Hamburg, Germany.
[Zurowski, Bartosz] Univ Lubeck, Dept Psychiat & Psychotherapy, D-23538 Lubeck, Germany.
RP Gamer, M (reprint author), Univ Med Ctr Hamburg Eppendorf, Dept Syst Neurosci, D-20246 Hamburg, Germany.
EM m.gamer@uke.uni-hamburg.de
RI Gamer, Matthias/E-7967-2010
FU Bundesministerium fur Bildung und Forschung (BMBF)
FX We thank G. Muller, K. Muller, and K. Wendt for help with MR scanning.
This study was supported by a grant from the Bundesministerium fur
Bildung und Forschung (BMBF, Network "Social Cognition").
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NR 52
TC 176
Z9 176
PU NATL ACAD SCIENCES
PI WASHINGTON
PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA
SN 0027-8424
J9 P NATL ACAD SCI USA
JI Proc. Natl. Acad. Sci. U. S. A.
PD MAY 18
PY 2010
VL 107
IS 20
BP 9400
EP 9405
DI 10.1073/pnas.1000985107
PG 6
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 598GH
UT WOS:000277822600068
PM 20421469
ER
PT J
AU Mervis, CB
John, AE
AF Mervis, Carolyn B.
John, Angela E.
TI Cognitive and Behavioral Characteristics of Children With Williams
Syndrome: Implications for Intervention Approaches
SO AMERICAN JOURNAL OF MEDICAL GENETICS PART C-SEMINARS IN MEDICAL GENETICS
LA English
DT Article
DE Williams syndrome; cognitive development; language development;
behavior; intervention
ID AUTISM SPECTRUM DISORDERS; READING-RELATED SKILLS; SCHOOL-AGE-CHILDREN;
SHORT-TERM-MEMORY; DOWN-SYNDROME; LINGUISTIC ABILITIES;
PERSONALITY-CHARACTERISTICS; NEUROPSYCHOLOGICAL PROFILE; INTELLECTUAL
DISABILITY; EMOTIONAL DISTURBANCE
AB Portrayals of individuals with Williams syndrome (WS), a genetic disorder caused by a microdeletion of similar to 25 genes on chromosome 7q11.23, have reached the general public through a variety of media formats. These descriptions are often paradoxical in nature with individuals with WS repeatedly described as demonstrating near-normal language despite the presence of significant intellectual disability and as being extremely sociable and friendly in spite of their seemingly limited understanding of basic social norms. While this depiction of WS served to attract the interest of basic-science researchers, the results of subsequent studies have provided a more nuanced view. For example, rather than across-the-board "near-normal" language, children with WS demonstrate relative strengths in concrete vocabulary and verbal short-term memory, grammatical abilities at the level expected for general intellectual ability, and considerable weakness in relational/conceptual language and pragmatics (social use of language). To provide a more thorough characterization of the WS behavioral phenotype, we summarize recent findings related to intellectual ability, language development, memory development, executive function development, adaptive behavior skills, and behavior as it relates to learning by children with WS. Finally, we briefly discuss intervention approaches that may help children with WS to achieve their full potential. (C) 2010 Wiley-Liss, Inc.
C1 [Mervis, Carolyn B.; John, Angela E.] Univ Louisville, Dept Psychol & Brain Sci, Louisville, KY 40292 USA.
RP Mervis, CB (reprint author), Univ Louisville, Dept Psychol & Brain Sci, 317 Life Sci Bldg, Louisville, KY 40292 USA.
EM cbmervis@louisville.edu
FU National Institute of Child Health and Human Development [R37 HD29959];
National Institute of Neurological Disorders and Stroke [R01 NS35102]
FX Grant sponsor: National Institute of Child Health and Human Development;
Grant number: R37 HD29959; Grant sponsor: National Institute of
Neurological Disorders and Stroke; Grant number: R01 NS35102.
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NR 156
TC 50
Z9 51
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1552-4868
EI 1552-4876
J9 AM J MED GENET C
JI Am. J. Med. Genet. C
PD MAY 15
PY 2010
VL 154C
IS 2
BP 229
EP 248
DI 10.1002/ajmg.c.30263
PG 20
WC Genetics & Heredity
SC Genetics & Heredity
GA 592HN
UT WOS:000277369200004
PM 20425784
ER
PT J
AU John, AE
Mervis, CB
AF John, Angela E.
Mervis, Carolyn B.
TI Sensory Modulation Impairments in Children with Williams Syndrome
SO AMERICAN JOURNAL OF MEDICAL GENETICS PART C-SEMINARS IN MEDICAL GENETICS
LA English
DT Article
DE Williams syndrome; sensory modulation; intellectual disability;
executive function; temperament; adaptive behavior; problem behavior
ID YOUNG-CHILDREN; AUTISM; PERSONALITY; INDIVIDUALS; PERFORMANCE;
HYPERACUSIS; PREVALENCE; DISORDERS; PHENOTYPE; SYMPTOMS
AB The ability to organize information detected by our senses ("sensory modulation") allows us to act or respond effectively to situations encountered, facilitating learning, social behavior, and day-to-day functioning. We hypothesized that children with Williams syndrome (WS) would demonstrate symptoms of poor sensory modulation and that these sensory modulation abnormalities contribute to the phenotype. Participants were 78 children with WS aged 4.00-10.95 years. Based on parent ratings on the Short Sensory Profile [SSP; Dunn, 1999], most children were classified as having definite sensory modulation issues. Cluster analysis identified the presence of two clusters varying in level of sensory modulation impairment. Children in the high impairment group demonstrated poorer adaptive functioning, executive functioning, more problem behaviors, and more difficult temperaments than children in the low impairment group. (C) 2010 Wiley-Liss, Inc.
C1 [John, Angela E.] Univ Louisville, Dept Psychol & Brain Sci, Louisville, KY 40292 USA.
RP John, AE (reprint author), Univ Louisville, Dept Psychol & Brain Sci, Louisville, KY 40292 USA.
EM aejohn11@gwise.louisville.edu
FU National Institute of Child Health and Human Development [R37 HD29957];
National Institute of Neurological Disorders and Stroke [R01 NS35102]
FX Grant sponsor: National Institute of Child Health and Human Development;
Grant number: R37 HD29957; Grant sponsor: National Institute of
Neurological Disorders and Stroke; Grant number: R01 NS35102.
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NR 63
TC 7
Z9 8
PU WILEY-LISS
PI HOBOKEN
PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 1552-4868
J9 AM J MED GENET C
JI Am. J. Med. Genet. C
PD MAY 15
PY 2010
VL 154C
IS 2
BP 266
EP 276
DI 10.1002/ajmg.c.30260
PG 11
WC Genetics & Heredity
SC Genetics & Heredity
GA 592HN
UT WOS:000277369200006
PM 20425786
ER
PT J
AU Campbell, L
McCabe, K
Leadbeater, K
Schall, U
Loughland, C
Rich, D
AF Campbell, Linda
McCabe, Kathryn
Leadbeater, Kate
Schall, Ulrich
Loughland, Carmel
Rich, Dominique
TI Visual scanning of faces in 22q11.2 deletion syndrome: Attention to the
mouth or the eyes?
SO PSYCHIATRY RESEARCH
LA English
DT Article
DE Emotion face processing; Visual scanpaths; Eye-gaze avoidance; Social
functioning
ID CARDIO-FACIAL SYNDROME; HUMAN AMYGDALA; CHILDREN; AUTISM; EMOTION;
FEARFUL; SCHIZOPHRENIA; EXPRESSIONS; ACTIVATION; DISORDERS
AB Previous research demonstrates that people with 22q11.2 deletion syndrome (22q11DS) have social and interpersonal skill deficits. However, the basis of this deficit is unknown. This study examined, for the first time, how people with 22q11DS process emotional face stimuli using visual scanpath technology. The visual scanpaths of 17 adolescents and age/gender matched healthy controls were recorded while they viewed face images depicting one of seven basic emotions (happy, sad, surprised, angry, fear, disgust and neutral). Recognition accuracy was measured concurrently. People with 22q11DS differed significantly from controls, displaying visual scanpath patterns that were characterised by fewer fixations and a shorter scanpath length. The 22q11DS group also spent significantly more time gazing at the mouth region and significantly less time looking at eye regions of the faces. Recognition accuracy was correspondingly impaired, with 22q11DS subjects displaying particular deficits for fear and disgust. These findings suggest that 22q11DS is associated with a maladaptive visual information processing strategy that may underlie affect recognition accuracy and social functioning deficits in this group. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
C1 [Campbell, Linda; McCabe, Kathryn; Leadbeater, Kate; Schall, Ulrich; Loughland, Carmel] Univ Newcastle, Prior Res Ctr Brain & Mental Hlth, Callaghan, NSW 2308, Australia.
[Campbell, Linda; McCabe, Kathryn; Schall, Ulrich; Loughland, Carmel] Schizophrenia Res Inst Australia, Sydney, NSW, Australia.
[Rich, Dominique] Univ Newcastle, Ctr Brain & Mental Hlth Res, Callaghan, NSW 2308, Australia.
RP Campbell, L (reprint author), Prior Res Ctr Brain & Mental Hlth Studies, POB 833, Newcastle, NSW 2300, Australia.
EM Linda.e.campbell@newcastle.edu.au
RI campbell, linda/C-6231-2013; SCHALL, ULRICH/G-7452-2013
OI campbell, linda/0000-0002-8872-9626;
FU Velo-Cardio-Facial Foundation of New South Wales; John D. and Catherine
T. MacArthur Foundation Research Network on Early Experience and Brain
Development; Hunter Medical Research Institute; NMMRC; NHMRC of
Australia, NHMRC ID [455614]
FX We thank the Velo-Cardio-Facial Foundation of New South Wales for their
support and help with recruitment. We also thank all the participants
and their families for helping us with the current study. Development of
the MacBrain Face Stimulus Set was overseen by Nim Tottenham and
supported by the John D. and Catherine T. MacArthur Foundation Research
Network on Early Experience and Brain Development. Please contact Nim
Tottenham at tott0006@tc.umn.edu for more information concerning the
stimulus set.Funding for the current study was obtained from the Hunter
Medical Research Institute in the form of a Port-Waratah Coal Services
post-doctoral fellowship and from the NM&MRC in the form of an
Australian Training Fellowship. Infra-structure support was also
obtained from the Schizophrenia Research Institute. The work recorded
has been supported by a Fellowship awarded by the NHMRC of Australia,
NHMRC ID 455614.
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NR 39
TC 13
Z9 14
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
IRELAND
SN 0165-1781
J9 PSYCHIAT RES
JI Psychiatry Res.
PD MAY 15
PY 2010
VL 177
IS 1-2
BP 211
EP 215
DI 10.1016/j.psychres.2009.06.007
PG 5
WC Psychiatry
SC Psychiatry
GA 604KV
UT WOS:000278278800038
PM 20381171
ER
PT J
AU Miller, DT
Adam, MP
Aradhya, S
Biesecker, LG
Brothman, AR
Carter, NP
Church, DM
Crolla, JA
Eichler, EE
Epstein, CJ
Faucett, WA
Feuk, L
Friedman, JM
Hamosh, A
Jackson, L
Kaminsky, EB
Kok, K
Krantz, ID
Kuhn, RM
Lee, C
Ostell, JM
Rosenberg, C
Scherer, SW
Spinner, NB
Stavropoulos, DJ
Tepperberg, JH
Thorland, EC
Vermeesch, JR
Waggoner, DJ
Watson, MS
Martin, CL
Ledbetter, DH
AF Miller, David T.
Adam, Margaret P.
Aradhya, Swaroop
Biesecker, Leslie G.
Brothman, Arthur R.
Carter, Nigel P.
Church, Deanna M.
Crolla, John A.
Eichler, Evan E.
Epstein, Charles J.
Faucett, W. Andrew
Feuk, Lars
Friedman, Jan M.
Hamosh, Ada
Jackson, Laird
Kaminsky, Erin B.
Kok, Klaas
Krantz, Ian D.
Kuhn, Robert M.
Lee, Charles
Ostell, James M.
Rosenberg, Carla
Scherer, Stephen W.
Spinner, Nancy B.
Stavropoulos, Dimitri J.
Tepperberg, James H.
Thorland, Erik C.
Vermeesch, Joris R.
Waggoner, Darrel J.
Watson, Michael S.
Martin, Christa Lese
Ledbetter, David H.
TI Consensus Statement: Chromosomal Microarray Is a First-Tier Clinical
Diagnostic Test for Individuals with Developmental Disabilities or
Congenital Anomalies
SO AMERICAN JOURNAL OF HUMAN GENETICS
LA English
DT Article
ID COMPARATIVE GENOMIC HYBRIDIZATION; IDIOPATHIC MENTAL-RETARDATION;
COPY-NUMBER VARIATIONS; 17Q21.31 MICRODELETION SYNDROME; ARRAY-BASED
TECHNOLOGY; LOW-LEVEL MOSAICISM; STRUCTURAL VARIATION; DYSMORPHIC
FEATURES; CYTOGENETIC SURVEY; OLIGONUCLEOTIDE MICROARRAY
AB Chromosomal microarray (CMA) is increasingly utilized for genetic testing of individuals with unexplained developmental delay/intellectual disability (DD/ID), autism spectrum disorders (ASD), or multiple congenital anomalies (MCA). Performing CMA and G-banded karyotyping on every patient substantially increases the total cost of genetic testing. The International Standard Cytogenomic Array (ISCA) Consortium held two international workshops and conducted a literature review of 33 studies, including 21,698 patients tested by CMA. We provide an evidence-based summary of clinical cytogenetic testing comparing CMA to G-banded karyotyping with respect to technical advantages and limitations, diagnostic yield for various types of chromosomal aberrations, and issues that affect test interpretation. CMA offers a much higher diagnostic yield (15%-20%) for genetic testing of individuals with unexplained DD/ID, ASD, or MCA than a G-banded karyotype (similar to 3%, excluding Down syndrome and other recognizable chromosomal syndromes), primarily because of its higher sensitivity for submicroscopic deletions and duplications. Truly balanced rearrangements and low-level mosaicism are generally not detectable by arrays, but these are relatively infrequent causes of abnormal phenotypes in this population (<1%). Available evidence strongly supports the use of CMA in place of G-banded karyotyping as the first-tier cytogenetic diagnostic test for patients with DD/ID, ASD, or MCA. G-banded karyotype analysis should be reserved for patients with obvious chromosomal syndromes (e.g., Down syndrome), a family history of chromosomal rearrangement, or a history of multiple miscarriages.
C1 [Miller, David T.] Childrens Hosp, Div Genet, Boston, MA 02115 USA.
[Miller, David T.] Childrens Hosp, Dept Lab Med, Boston, MA 02115 USA.
[Miller, David T.] Harvard Univ, Sch Med, Boston, MA USA.
[Adam, Margaret P.; Faucett, W. Andrew; Kaminsky, Erin B.; Martin, Christa Lese; Ledbetter, David H.] Emory Univ, Sch Med, Dept Human Genet, Atlanta, GA USA.
[Adam, Margaret P.] Univ Washington, Sch Med, Dept Pediat, Seattle, WA 98195 USA.
[Aradhya, Swaroop] GeneDx, Gaithersburg, MD USA.
[Biesecker, Leslie G.] NHGRI, NIH, Bethesda, MD 20892 USA.
[Brothman, Arthur R.] Univ Utah, Sch Med, Dept Pediat, Human Genet Lab, Salt Lake City, UT USA.
[Brothman, Arthur R.] Univ Utah, Sch Med, Dept Pediat, Pathol Lab, Salt Lake City, UT USA.
[Brothman, Arthur R.] Univ Utah, Sch Med, Dept Pediat, ARUP Lab, Salt Lake City, UT USA.
[Carter, Nigel P.] Wellcome Trust Sanger Inst, Cambridge, England.
[Church, Deanna M.; Ostell, James M.] Natl Lib Med, Natl Ctr Biotechnol Informat, Bethesda, MD 20894 USA.
[Crolla, John A.] Natl Genet Reference Lab Wessex, Salisbury, Wilts, England.
[Eichler, Evan E.] Univ Washington, Sch Med, Dept Genome Sci, Seattle, WA USA.
[Eichler, Evan E.] Univ Washington, Howard Hughes Med Inst, Sch Med, Seattle, WA 98195 USA.
[Epstein, Charles J.] Univ Calif San Francisco, Inst Human Genet, San Francisco, CA 94143 USA.
[Epstein, Charles J.] Univ Calif San Francisco, Dept Pediat, San Francisco, CA 94143 USA.
[Feuk, Lars] Uppsala Univ, Rudbeck Lab, Uppsala, Sweden.
[Friedman, Jan M.] Univ British Columbia, Dept Med Genet, Vancouver, BC, Canada.
[Friedman, Jan M.] Child & Family Res Inst, Vancouver, BC, Canada.
[Hamosh, Ada] Johns Hopkins Univ, Sch Med, Dept Pediat, Baltimore, MD 21205 USA.
[Hamosh, Ada] Johns Hopkins Univ, Sch Med, McKusick Nathans Inst Genet Med, Baltimore, MD USA.
[Jackson, Laird] Drexel Univ, Coll Med, Dept Obstet & Gynecol, Philadelphia, PA 19104 USA.
[Kok, Klaas] Univ Groningen, Univ Med Ctr Groningen, Dept Genet, NL-9700 AB Groningen, Netherlands.
[Krantz, Ian D.; Spinner, Nancy B.] Univ Penn, Childrens Hosp Philadelphia, Sch Med, Dept Pediat Human Genet, Philadelphia, PA 19104 USA.
[Kuhn, Robert M.] Univ Calif Santa Cruz, Ctr Biomol Sci & Engn, Santa Cruz, CA 95064 USA.
[Lee, Charles] Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Pathol, Boston, MA 02115 USA.
[Rosenberg, Carla] Univ Sao Paulo, Dept Genet & Evolutionary Biol, BR-05508 Sao Paulo, Brazil.
[Scherer, Stephen W.] Univ Toronto, Hosp Sick Children, Ctr Appl Genom, Toronto, ON M5S 1A1, Canada.
[Scherer, Stephen W.] Univ Toronto, Hosp Sick Children, Program Genet & Genet Biol, Toronto, ON M5S 1A1, Canada.
[Scherer, Stephen W.] Univ Toronto, Dept Mol Genet, Toronto, ON M5S 1A1, Canada.
[Stavropoulos, Dimitri J.] Hosp Sick Children, Dept Pediat Lab Med, Toronto, ON M5G 1X8, Canada.
[Tepperberg, James H.] Lab Corp Amer, Res Triangle Pk, NC USA.
[Thorland, Erik C.] Mayo Clin, Rochester, MN USA.
[Vermeesch, Joris R.] Katholieke Univ Leuven, Ctr Human Genet, Leuven, Belgium.
[Waggoner, Darrel J.] Univ Chicago, Dept Human Genet & Pediat, Chicago, IL 60637 USA.
[Watson, Michael S.] Amer Coll Med Genet, Bethesda, MI USA.
RP Miller, DT (reprint author), Childrens Hosp, Div Genet, 300 Longwood Ave, Boston, MA 02115 USA.
EM david.miller2@childrens.harvard.edu; david.ledbetter@emory.edu
RI Howe, Jennifer/I-9013-2012; Scherer, Stephen /B-3785-2013; Oncogenomica,
Inct/H-9999-2013; Cetgen, Inct/I-2412-2013
OI Scherer, Stephen /0000-0002-8326-1999;
FU National Institutes of Health [RC2FID064525, MH074090]; Simons
Foundation [137578]; ACMG Foundation; Luminex
FX Workshops and conference calls related to the ISCA Consortium were
funded through a grant from the ACMG Foundation and Luminex to D.H.L.
and C.L.M., and ongoing standards and database development are funded in
part by grants from the National Institutes of Health (RC2FID064525 and
MH074090 to D.H.L. and C.L.M.). This work was also supported by Simons
Foundation grant 137578 (to FEE.). E.E.E. is an investigator of the
Howard Hughes Medical Institute. The opinions expressed here are those
of the authors and the ISCA Consortium and do not necessarily reflect
the views of the institutions to which the authors are affiliated, the
ACMG, or the American Society of Human Genetics (ASHG). The authors
would like to thank Dr. Omer Gokcumen for his assistance with summary of
population CNV data. Regarding conflict of interest, the majority of
authors are involved in CMA testing and/or cytogenetic testing, either
as clinicians who order the testing, laboratory professionals who
perform the testing, or researchers in the genomics field. S.A. is a
director of clinical cytogenetics at GeneDx, a subsidiary of
BioReference Laboratories; A.R.B. is a director of clinical cytogenetics
and molecular cytogenetics at ARUP Laboratories; E.E.E. is a member of
the Pacific Biosciences Scientific Advisory Board. S.W.S. is on the
Scientific Advisory Board of Combimatrix Diagnostics and the Scientific
Advisory Committee of Autism Speaks. J.T. is a director of clinical
cytogenetics at Laboratory Corporation of America. J.V. is on the board
of directors of Cartagenia. M.W. raises funds from industry to support
the educational activities of the ACMG Foundation.
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NR 107
TC 573
Z9 597
PU CELL PRESS
PI CAMBRIDGE
PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA
SN 0002-9297
J9 AM J HUM GENET
JI Am. J. Hum. Genet.
PD MAY 14
PY 2010
VL 86
IS 5
BP 749
EP 764
DI 10.1016/j.ajhg.2010.04.006
PG 16
WC Genetics & Heredity
SC Genetics & Heredity
GA 601GC
UT WOS:000278045300011
PM 20466091
ER
PT J
AU Shah, AK
Tioleco, NM
Nolan, K
Locker, J
Groh, K
Villa, C
Stopkova, P
Pedrosa, E
Lachman, HM
AF Shah, Abhishek K.
Tioleco, Nina M.
Nolan, Karen
Locker, Joseph
Groh, Katherine
Villa, Catalina
Stopkova, Pavla
Pedrosa, Erika
Lachman, Herbert M.
TI Rare NRXN1 promoter variants in patients with schizophrenia
SO NEUROSCIENCE LETTERS
LA English
DT Article
DE Neurexin; Schizophrenia; Bipolar disorder; Autism; CNV; Copy variant
ID ALPHA-NEUREXINS; TRANSCRIPTION FACTOR; GENE; ASSOCIATION; EXPRESSION;
DEPENDENCE; APOPTOSIS; ENHANCER; SYNAPSE; AUTISM
AB Copy number variants (CNVs) affecting the neurexin 1 (NRXN1) gene have been found in a subgroup of patients with schizophrenia (SZ). NRXN1 expression is complex, with multiple alternative splice forms generated from two major transcripts; NRXN1 alpha and NRXN1 beta. The majority of CNVs in SZ are deletions affecting the proximal NRXN1 alpha exons and promoter region. Rare chromosomal events are useful in understanding the genetic basis of complex psychiatric disorders since affected genes become feasible targets to analyze for more subtle genetic alterations. As a first step towards this goal, we resequenced the NRXN1 alpha promoter region in 170 patients with SZ and a similar number of controls. Two rare mutations were identified in the patient population. One previously unknown single nucleotide polymorphism (SNP) was found in controls. Bioinformatics analysis suggests that binding to several transcription factors may be affected by the minor alleles. The findings suggest that in addition to chromosomal alterations disrupting the NRXN1 alpha promoter, rare point mutations in the region may also be involved in SZ pathogenesis. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
C1 [Shah, Abhishek K.; Tioleco, Nina M.; Groh, Katherine; Villa, Catalina; Pedrosa, Erika; Lachman, Herbert M.] Albert Einstein Coll Med, Basic Res Div, Dept Psychiat & Behav Sci, Bronx, NY 10461 USA.
[Nolan, Karen] Nathan S Kline Inst Psychiat Res, Orangeburg, NY 10962 USA.
[Nolan, Karen] NYU, Sch Med, Dept Psychiat, New York, NY USA.
[Locker, Joseph] Albert Einstein Coll Med, Dept Pathol, Bronx, NY 10461 USA.
[Stopkova, Pavla] Prague Psychiat Ctr, Prague, Czech Republic.
RP Lachman, HM (reprint author), Albert Einstein Coll Med, Basic Res Div, Dept Psychiat & Behav Sci, 1300 Morris Pk Ave, Bronx, NY 10461 USA.
EM Herb.Lachman@einstein.yu.edu
FU NIMH [MH073164]; Juvenile Bipolar Research Foundation; New York State
Office of Mental Health; NARSAD; MZCR [MZ0PCP2005]
FX HML is supported by NIMH (MH073164) and the Juvenile Bipolar Research
Foundation. AKS is supported by the New York State Office of Mental
Health. KN is supported by a young investigator award from NARSAD. PS is
supported by a research grant from MZCR MZ0PCP2005. The authors would
like to thank Tomas Novak for recruiting patients in the Czech bipolar
cohort, and Hana Fridrichova for administrative support.
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NR 30
TC 14
Z9 15
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
IRELAND
SN 0304-3940
J9 NEUROSCI LETT
JI Neurosci. Lett.
PD MAY 14
PY 2010
VL 475
IS 2
BP 80
EP 84
DI 10.1016/j.neulet.2010.03.047
PG 5
WC Neurosciences
SC Neurosciences & Neurology
GA 623ZD
UT WOS:000279785000005
PM 20347009
ER
PT J
AU Zhang, C
Atasoy, D
Arac, D
Yang, XF
Fucillo, MV
Robison, AJ
Ko, JW
Brunger, AT
Sudhof, TC
AF Zhang, Chen
Atasoy, Deniz
Arac, Demet
Yang, Xiaofei
Fucillo, Marc V.
Robison, Alfred J.
Ko, Jaewon
Brunger, Axel T.
Sudhof, Thomas C.
TI Neurexins Physically and Functionally Interact with GABA(A) Receptors
SO NEURON
LA English
DT Article
ID EXCITATORY SYNAPSE FORMATION; AUTISM SPECTRUM DISORDER; CELL-SURFACE
PROTEINS; ALPHA-NEUREXINS; BETA-NEUREXINS; DROSOPHILA NEUREXIN;
INHIBITORY SYNAPSES; SUBUNIT GENES; CA2+ CHANNELS; NEUROLIGIN 1
AB Neurexins are presynaptic cell-adhesion molecules that form trans-synaptic complexes with postsynaptic neuroligins. When overexpressed in nonneuronal cells, neurexins induce formation of postsynaptic specializations in cocultured neurons, suggesting that neurexins are synaptogenic. However, we find that when overexpressed in neurons, neurexins do not increase synapse density, but instead selectively suppressed GABAergic synaptic transmission without decreasing GABAergic synapse numbers. This suppression was mediated by all subtypes of neurexins tested, in a cell-autonomous and neuroligin-independent manner. Strikingly, addition of recombinant neurexin to cultured neurons at submicromolar concentrations induced the same suppression of GABAergic synaptic transmission as neurexin overexpression. Moreover, experiments with native brain proteins and purified recombinant proteins revealed that neurexins directly and stoichiometrically bind to GABA(A) receptors, suggesting that they decrease GABAergic synaptic responses by interacting with GABA(A) receptors. Our findings suggest that besides their other well-documented interactions, presynaptic neurexins directly act on postsynaptic GABA(A) receptors, which may contribute to regulate the excitatory/inhibitory balance in brain.
C1 [Zhang, Chen; Arac, Demet; Yang, Xiaofei; Fucillo, Marc V.; Ko, Jaewon; Brunger, Axel T.; Sudhof, Thomas C.] Stanford Univ, Dept Mol & Cellular Physiol, Palo Alto, CA 94304 USA.
[Atasoy, Deniz; Brunger, Axel T.; Sudhof, Thomas C.] Stanford Univ, Howard Hughes Med Inst, Palo Alto, CA 94304 USA.
[Arac, Demet; Brunger, Axel T.] Stanford Univ, Dept Neurol & Neurol Sci, Palo Alto, CA 94304 USA.
[Arac, Demet; Brunger, Axel T.] Stanford Univ, Dept Biol Struct, Palo Alto, CA 94304 USA.
[Arac, Demet; Brunger, Axel T.] Stanford Univ, Dept Photon Sci, Palo Alto, CA 94304 USA.
[Sudhof, Thomas C.] Univ Texas SW Med Ctr Dallas, Howard Hughes Med Inst, Dallas, TX 75390 USA.
[Sudhof, Thomas C.] Univ Texas SW Med Ctr Dallas, Dept Mol Genet, Dallas, TX 75390 USA.
[Zhang, Chen; Atasoy, Deniz; Yang, Xiaofei; Robison, Alfred J.; Sudhof, Thomas C.] Univ Texas SW Med Ctr Dallas, Dept Neurosci, Dallas, TX 75390 USA.
RP Sudhof, TC (reprint author), Stanford Univ, Dept Mol & Cellular Physiol, 1050 Arastradero Rd, Palo Alto, CA 94304 USA.
EM tcs1@stanford.edu
FU NIMH [MH52804]; Simons Foundation; Life Sciences Research Foundation;
Human Frontier Science Program Organization
FX We would like to thank Dr. Robert L. Macdonald (Vanderbilt University)
and Dr. Stephen Moss (Tufts University) for gifts of valuable reagents.
This paper was supported by grants from the NIMH (MH52804 to T.C.S.) and
the Simons Foundation (to T.C.S.), and fellowships from the Life
Sciences Research Foundation (to D.A.) and the Human Frontier Science
Program Organization (to J.K.).
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NR 67
TC 48
Z9 49
PU CELL PRESS
PI CAMBRIDGE
PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA
SN 0896-6273
J9 NEURON
JI Neuron
PD MAY 13
PY 2010
VL 66
IS 3
BP 403
EP 416
DI 10.1016/j.neuron.2010.04.008
PG 14
WC Neurosciences
SC Neurosciences & Neurology
GA 598HE
UT WOS:000277825200009
PM 20471353
ER
PT J
AU Dinstein, I
Thomas, C
Humphreys, K
Minshew, N
Behrmann, M
Heeger, DJ
AF Dinstein, Ilan
Thomas, Cibu
Humphreys, Kate
Minshew, Nancy
Behrmann, Marlene
Heeger, David J.
TI Normal Movement Selectivity in Autism
SO NEURON
LA English
DT Article
ID MIRROR-NEURON SYSTEM; FUNCTIONAL MAGNETIC-RESONANCE; SPECTRUM DISORDERS;
CORTICAL ACTIVATION; IMITATION; ADAPTATION; FMRI; REPRESENTATION;
CHILDREN; CORTEX
AB It has been proposed that individuals with autism have difficulties understanding the goals and intentions of others because of a fundamental dysfunction in the mirror neuron system. Here, however, we show that individuals with autism exhibited not only normal fMRI responses in mirror system areas during observation and execution of hand movements but also exhibited typical movement-selective adaptation (repetition suppression) when observing or executing the same movement repeatedly. Movement selectivity is a defining characteristic of neurons involved in movement perception, including mirror neurons, and, as such, these findings argue against a mirror system dysfunction in autism.
C1 [Dinstein, Ilan; Heeger, David J.] NYU, Ctr Neural Sci, New York, NY 10003 USA.
[Heeger, David J.] NYU, Dept Psychol, New York, NY 10003 USA.
[Thomas, Cibu; Humphreys, Kate; Behrmann, Marlene] Carnegie Mellon Univ, Dept Psychol, Pittsburgh, PA 15213 USA.
[Minshew, Nancy] Univ Pittsburgh, Dept Neurol, Pittsburgh, PA 15213 USA.
RP Dinstein, I (reprint author), NYU, Ctr Neural Sci, 6 Washington Pl, New York, NY 10003 USA.
EM ilan.dinstein@weizmann.ac.il
FU National Institutes of Health [R01-MH069880]; NICHD/NIDCD [PO1/U19];
Pennsylvania Department of Health [SAP 4100047862]; Cure Autism Now
(Young Investigator Award); [F31-MH080457]
FX Supported by National Institutes of Health Grants R01-MH069880 (D.J.H.),
NICHD/NIDCD PO1/U19 (M.B.; PI: Nancy Minshew), F31-MH080457 (ID.),
Pennsylvania Department of Health grant SAP 4100047862, and Cure Autism
Now (Young Investigator Award, K.H.).
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NR 48
TC 61
Z9 62
PU CELL PRESS
PI CAMBRIDGE
PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA
SN 0896-6273
J9 NEURON
JI Neuron
PD MAY 13
PY 2010
VL 66
IS 3
BP 461
EP 469
DI 10.1016/j.neuron.2010.03.034
PG 9
WC Neurosciences
SC Neurosciences & Neurology
GA 598HE
UT WOS:000277825200014
PM 20471358
ER
PT J
AU Becchio, C
Mari, M
Castiello, U
AF Becchio, Cristina
Mari, Morena
Castiello, Umberto
TI Perception of Shadows in Children with Autism Spectrum Disorders
SO PLOS ONE
LA English
DT Article
ID VISUAL-SEARCH; CAST SHADOWS; INDIVIDUALS; TASK
AB Background: Cast shadows in visual scenes can have profound effects on visual perception. Much as they are informative, they also constitute noise as they are salient features of the visual scene potentially interfering with the processing of other features. Here we asked i) whether individuals with autism can exploit the information conveyed by cast shadows; ii) whether they are especially sensitive to noise aspects of shadows.
Methodology/Principal Findings: Twenty high-functioning children with autism and twenty typically developing children were asked to recognize familiar objects while the presence, position, and shape of the cast shadow were systematically manipulated. Analysis of vocal reaction time revealed that whereas typically developing children used information from cast shadows to improve object recognition, in autistic children the presence of cast shadows-either congruent or incongruent-interfered with object recognition. Critically, vocal reaction times were faster when the object was presented without a cast shadow.
Conclusions/Significance: We conclude that shadow-processing mechanisms are abnormal in autism. As a result, processing shadows becomes costly and cast shadows interfere rather than help object recognition.
C1 [Becchio, Cristina] Univ Turin, Dipartimento Psicol, Ctr Cognit Sci, Turin, Italy.
[Mari, Morena; Castiello, Umberto] Univ Padua, Dipartimento Psicol Gen, Padua, Italy.
RP Becchio, C (reprint author), Univ Turin, Dipartimento Psicol, Ctr Cognit Sci, Turin, Italy.
EM umberto.castiello@unipd.it
FU Regione Piemonte; bando Scienze Umane e Sociali [4/2006]
FX CB was supported by the Regione Piemonte, bando Scienze Umane e Sociali
2008, L.R. n. 4/2006. The funders had no role in study design, data
collection and analysis, decision to publish, or preparation of the
manuscript.
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NR 32
TC 5
Z9 5
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD MAY 11
PY 2010
VL 5
IS 5
AR e10582
DI 10.1371/journal.pone.0010582
PG 5
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 594UB
UT WOS:000277563200015
PM 20485498
ER
PT J
AU Cheung, I
Shulha, HP
Jiang, Y
Matevossian, A
Wang, J
Weng, ZP
Akbarian, S
AF Cheung, Iris
Shulha, Hennady P.
Jiang, Yan
Matevossian, Anouch
Wang, Jie
Weng, Zhiping
Akbarian, Schahram
TI Developmental regulation and individual differences of neuronal H3K4me3
epigenomes in the prefrontal cortex
SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF
AMERICA
LA English
DT Article
DE cerebral cortex; neuron; histone methylation; human; brain; gene
expression
ID EPIGENETIC REGULATION; HUMAN GENOME; HUMAN BRAIN; GENE-EXPRESSION;
SCHIZOPHRENIA; CHROMATIN; METHYLATION; DISORDER; MATTER; AUTISM
AB Little is known about the regulation of neuronal and other cell-type specific epigenomes from the brain. Here, we map the genome-wide distribution of trimethylated histone H3K4 (H3K4me3), a mark associated with transcriptional regulation, in neuronal and nonneuronal nuclei collected from prefrontal cortex (PFC) of 11 individuals ranging in age from 0.5 to 69 years. Massively parallel sequencing identified 12,732-19,704 H3K4me3 enriched regions (peaks), the majority located proximal to (within 2 kb of) the transcription start site (TSS) of annotated genes. These included peaks shared by neurons in comparison with three control (lymphocyte) cell types, as well as peaks specific to individual subjects. We identified 6,213 genes that show highly enriched H3K4me3 in neurons versus control. At least 1,370 loci, including annotated genes and novel transcripts, were selectively tagged with H3K4me3 in neuronal but not in nonneuronal PFC chromatin. Our results reveal age-correlated neuronal epigenome reorganization, including decreased H3K4me3 at approximately 600 genes (many function in developmental processes) during the first year after birth. In comparison, the epigenome of aging (> 60 years) PFC neurons showed less extensive changes, including increased H3K4me3 at 100 genes. These findings demonstrate that H3K4me3 in human PFC is highly regulated in a cell type-and subject-specific manner and highlight the importance of early childhood for developmentally regulated chromatin remodeling in prefrontal neurons.
C1 [Cheung, Iris; Jiang, Yan; Matevossian, Anouch; Akbarian, Schahram] Univ Massachusetts, Sch Med, Brudnick Neuropsychiat Res Inst, Dept Psychiat, Worcester, MA 01604 USA.
[Wang, Jie; Weng, Zhiping] Univ Massachusetts, Sch Med, Program Bioinformat & Integrat Biol, Worcester, MA 01604 USA.
[Weng, Zhiping] Univ Massachusetts, Sch Med, Dept Mol Pharmacol & Biochem, Worcester, MA 01604 USA.
[Shulha, Hennady P.; Weng, Zhiping] Boston Univ, Boston, MA 02215 USA.
RP Akbarian, S (reprint author), Univ Massachusetts, Sch Med, Brudnick Neuropsychiat Res Inst, Dept Psychiat, Worcester, MA 01604 USA.
EM zhiping.weng@umassmed.edu; schahram.akbarian@umassmed.edu
RI Jiang, yan/C-7126-2011; Wang, Jie/F-9747-2011
FU National Institute of Mental Health [5RC1MH088047, 5R01-MH071476];
International Mental Health Research Organization; National Science
Foundation [DBI 085008]
FX We thank Dr. Ellen Kittler and Dr. Maria Zapp and the staff of
theUMMSDeep Sequencing Core for expert advice and support, Dr. Oliver
Rando for insightful discussions, and Dr. Yin Guo for excellent
technical assistances. We are also grateful for the H3K4me3 datasets on
GM12878 and K562, which were produced by the Bradley Bernstein group in
the ENCODE consortium and distributed by the ENCODE data coordination
center at UCSC. This work was supported by National Institute of Mental
Health Grants 5RC1MH088047 and 5R01-MH071476 and by funds from the
International Mental Health Research Organization (to S. A.) and
National Science Foundation Grant DBI 085008 (to Z.W.).
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NR 32
TC 76
Z9 78
PU NATL ACAD SCIENCES
PI WASHINGTON
PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA
SN 0027-8424
J9 P NATL ACAD SCI USA
JI Proc. Natl. Acad. Sci. U. S. A.
PD MAY 11
PY 2010
VL 107
IS 19
BP 8824
EP 8829
DI 10.1073/pnas.1001702107
PG 6
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 595DP
UT WOS:000277591200060
PM 20421462
ER
PT J
AU Buizer-Voskamp, JE
Franke, L
Staal, WG
van Daalen, E
Kemner, C
Ophoff, RA
Vorstman, JAS
van Engeland, H
Wijmenga, C
AF Buizer-Voskamp, Jacobine E.
Franke, Lude
Staal, Wouter G.
van Daalen, Emma
Kemner, Chantal
Ophoff, Roel A.
Vorstman, Jacob A. S.
van Engeland, Herman
Wijmenga, Cisca
TI Systematic genotype-phenotype analysis of autism susceptibility loci
implicates additional symptoms to co-occur with autism
SO EUROPEAN JOURNAL OF HUMAN GENETICS
LA English
DT Article
DE autistic disorder; genotype; phenotype; databases; genetic; medical
subject headings
ID SPECTRUM DISORDERS; MENTAL-RETARDATION; PSYCHIATRIC-DISORDERS;
ASSOCIATION ANALYSIS; GENOMEWIDE SCREEN; HUMAN PHENOME; HUMAN HEIGHT;
EPILEPSY; CHILDREN; GENETICS
AB Many genetic studies in autism have been performed, resulting in the identification of multiple linkage regions and cytogenetic aberrations, but little unequivocal evidence for the involvement of specific genes exists. By identifying novel symptoms in these patients, enhanced phenotyping of autistic individuals not only improves understanding and diagnosis but also helps to define biologically more homogeneous groups of patients, improving the potential to detect causative genes. Supported by recent copy number variation findings in autism, we hypothesized that for some susceptibility loci, autism resembles a contiguous gene syndrome, caused by aberrations within multiple (contiguous) genes, which jointly increases autism susceptibility. This would result in various different clinical manifestations that might be rather atypical, but that also co-occur with autism. To test this hypothesis, 13 susceptibility loci, identified through genetic linkage and cytogenetic analyses, were systematically analyzed. The Online Mendelian Inheritance in Man database was used to identify syndromes caused by mutations in the genes residing in each of these loci. Subsequent analysis of the symptoms expressed within these disorders allowed us to identify 33 symptoms (significantly more than expected, P = 0.037) that were over-represented in previous reports mapping to these loci. Some of these symptoms, including seizures and craniofacial abnormalities, support our hypothesis as they are already known to co-occur with autism. These symptoms, together with ones that have not previously been described to co-occur with autism, might be considered for use as inclusion or exclusion criteria toward defining etiologically more homogeneous groups for molecular genetic studies of autism European Journal of Human Genetics (2010) 18, 588-595; doi:10.1038/ejhg.2009.206; published online 25 November 2009
C1 [Franke, Lude; Wijmenga, Cisca] Univ Groningen, Univ Med Ctr Groningen, Dept Genet, NL-9700 RB Groningen, Netherlands.
[Buizer-Voskamp, Jacobine E.; Vorstman, Jacob A. S.] Univ Med Ctr, Dept Psychiat, Rudolf Magnus Inst Neurosci, Utrecht, Netherlands.
[Buizer-Voskamp, Jacobine E.; Ophoff, Roel A.] Univ Med Ctr, DBG Dept Med Genet, Complex Genet Sect, Utrecht, Netherlands.
[Staal, Wouter G.; van Daalen, Emma; Kemner, Chantal; van Engeland, Herman] Univ Med Ctr, Rudolf Magnus Inst Neurosci, Dept Child & Adolescent Psychiat, Utrecht, Netherlands.
RP Franke, L (reprint author), Univ Groningen, Univ Med Ctr Groningen, Dept Genet, POB 30001, NL-9700 RB Groningen, Netherlands.
EM lude@ludesign.nl
RI Wijmenga, Cisca/D-2173-2009
FU Netherlands Genomics Initiative; Celiac Disease Consortium; Dutch
government [BSIK03009]
FX We thank Jackie Senior, Sasha Zhernakova, Madelien van de Beek, members
of the Complex Genetics Section, the Department of Human Genetics, and
the Department of Child & Adolescent Psychiatry for a critical reading
of the paper. This study was supported by a Fellowship from the
Netherlands Genomics Initiative and a grant from the Celiac Disease
Consortium, an innovative cluster approved by the Netherlands Genomics
Initiative and partially funded by a Dutch government Grant (BSIK03009).
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NR 58
TC 2
Z9 2
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1018-4813
J9 EUR J HUM GENET
JI Eur. J. Hum. Genet.
PD MAY 10
PY 2010
VL 18
IS 5
BP 588
EP 595
DI 10.1038/ejhg.2009.206
PG 8
WC Biochemistry & Molecular Biology; Genetics & Heredity
SC Biochemistry & Molecular Biology; Genetics & Heredity
GA 586ZO
UT WOS:000276955500015
PM 19935830
ER
PT J
AU Mrozek-Budzyn, D
Kieltyka, A
Majewska, R
AF Mrozek-Budzyn, Dorota
Kieltyka, Agnieszka
Majewska, Renata
TI Lack of Association Between Measles-Mumps-Rubella Vaccination and Autism
in Children A Case-Control Study
SO PEDIATRIC INFECTIOUS DISEASE JOURNAL
LA English
DT Article
DE MMR vaccine; autism; children
ID MMR VACCINE; DISORDER; VIRUS
AB Objective: The first objective of the study was to determine whether there is a relationship between the measles-mumps-rubella (MMR) vaccination and autism in children. The second objective was to examine whether the risk of autism differs between use of MMR and the single measles vaccine.
Design: Case-control study.
Study Population: The 96 cases with childhood or atypical autism, aged 2 to 15, were included into the study group. Controls consisted of 192 children individually matched to cases by year of birth, sex, and general practitioners.
Methods: Data on autism diagnosis and vaccination history were from physicians. Data on the other probable autism risk factors were collected from mothers. Logistic conditional regression was used to assess the risk of autism resulting from vaccination. Assessment was made for children vaccinated (1) Before diagnosis of autism, and (2) Before first symptoms of autism onset. Odds ratios were adjusted to mother's age, medication during pregnancy, gestation time, perinatal injury and Apgar score.
Results: For children vaccinated before diagnosis, autism risk was lower in children vaccinated with MMR than in the nonvaccinated (OR: 0.17, 95% CI: 0.06-0.52) as well as to vaccinated with single measles vaccine (OR: 0.44, 95% CI: 0.22-0.91). The risk for vaccinated versus nonvaccinated (independent of vaccine type) was 0.28 (95% CI: 0.10-0.76). The risk connected with being vaccinated before onset of first symptoms was significantly lower only for MMR versus single vaccine (OR: 0.47, 95% CI: 0.22-0.99).
Conclusions: The study provides evidence against the association of autism with either MMR or a single measles vaccine.
C1 [Mrozek-Budzyn, Dorota; Kieltyka, Agnieszka; Majewska, Renata] Jagiellonian Univ, Coll Med, Chair Epidemiol & Prevent Med, Dept Epidemiol & Prevent Med, PL-31034 Krakow, Poland.
RP Mrozek-Budzyn, D (reprint author), Jagiellonian Univ, Coll Med, Chair Epidemiol & Prevent Med, Dept Epidemiol & Prevent Med, Kopernika 7A, PL-31034 Krakow, Poland.
EM dorotamrozek@tlen.pl
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NR 20
TC 15
Z9 15
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0891-3668
J9 PEDIATR INFECT DIS J
JI Pediatr. Infect. Dis. J.
PD MAY 10
PY 2010
VL 29
IS 5
BP 397
EP 400
DI 10.1097/INF.0b013e3181c40a8a
PG 4
WC Immunology; Infectious Diseases; Pediatrics
SC Immunology; Infectious Diseases; Pediatrics
GA 590IJ
UT WOS:000277218600002
PM 19952979
ER
PT J
AU Handley, MTW
Lian, LY
Haynes, LP
Burgoyne, RD
AF Handley, Mark T. W.
Lian, Lu-Yun
Haynes, Lee P.
Burgoyne, Robert D.
TI Structural and Functional Deficits in a Neuronal Calcium Sensor-1 Mutant
Identified in a Case of Autistic Spectrum Disorder
SO PLOS ONE
LA English
DT Article
ID LINKED MENTAL-RETARDATION; INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR;
PHOSPHATIDYLINOSITOL 4-OH KINASE; CA2+ SIGNAL-TRANSDUCTION; ACCESSORY
PROTEIN-LIKE; TRANS-GOLGI NETWORK; BINDING-PROTEINS; NEURITE OUTGROWTH;
IL1RAPL1 GENE; PC12 CELLS
AB Neuronal calcium sensor-1 (NCS-1) is a Ca(2+) sensor protein that has been implicated in the regulation of various aspects of neuronal development and neurotransmission. It exerts its effects through interactions with a range of target proteins one of which is interleukin receptor accessory protein like-1 (IL1RAPL1) protein. Mutations in IL1RAPL1 have recently been associated with autism spectrum disorders and a missense mutation (R102Q) on NCS-1 has been found in one individual with autism. We have examined the effect of this mutation on the structure and function of NCS-1. From use of NMR spectroscopy, it appeared that the R102Q affected the structure of the protein particularly with an increase in the extent of conformational exchange in the C-terminus of the protein. Despite this change NCS-1(R102Q) did not show changes in its affinity for Ca(2+) or binding to IL1RAPL1 and its intracellular localisation was unaffected. Assessment of NCS-1 dynamics indicated that it could rapidly cycle between cytosolic and membrane pools and that the cycling onto the plasma membrane was specifically changed in NCS-1(R102Q) with the loss of a Ca(2+)-dependent component. From these data we speculate that impairment of the normal cycling of NCS-1 by the R102Q mutation could have subtle effects on neuronal signalling and physiology in the developing and adult brain.
C1 [Handley, Mark T. W.; Haynes, Lee P.; Burgoyne, Robert D.] Univ Liverpool, Sch Biomed Sci, Physiol Lab, Liverpool L69 3BX, Merseyside, England.
[Lian, Lu-Yun] Univ Liverpool, Sch Biol Sci, Liverpool L69 3BX, Merseyside, England.
RP Handley, MTW (reprint author), Univ Liverpool, Sch Biomed Sci, Physiol Lab, Liverpool L69 3BX, Merseyside, England.
EM burgoyne@liv.ac.uk
RI Burgoyne, Robert/C-6706-2008
OI Burgoyne, Robert/0000-0002-9219-0387
FU Wellcome Trust [080796/Z/06/Z]
FX This work was supported by the Wellcome Trust (grant number
080796/Z/06/Z) to RDB. The funders had no role in study design, data
collection and analysis, decision to publish, or preparation of the
manuscript.
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NR 66
TC 27
Z9 29
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD MAY 7
PY 2010
VL 5
IS 5
AR e10534
DI 10.1371/journal.pone.0010534
PG 14
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 593OI
UT WOS:000277467800016
PM 20479890
ER
PT J
AU Tansey, KE
Brookes, KJ
Hill, MJ
Cochrane, LE
Gill, M
Skuse, D
Correia, C
Vicente, A
Kent, L
Gallagher, L
Anney, RJL
AF Tansey, Katherine E.
Brookes, Keeley J.
Hill, Matthew J.
Cochrane, Lynne E.
Gill, Michael
Skuse, David
Correia, Catarina
Vicente, Astrid
Kent, Lindsey
Gallagher, Louise
Anney, Richard J. L.
TI Oxytocin receptor (OXTR) does not play a major role in the aetiology of
autism: Genetic and molecular studies
SO NEUROSCIENCE LETTERS
LA English
DT Article
DE Oxytocin; Autism; Oxytocin receptor; Allelic expression imbalance;
cis-Acting variation
ID PERVASIVE DEVELOPMENTAL DISORDERS; GENOME-WIDE; AFFILIATIVE BEHAVIOR;
LINKAGE ANALYSES; ASSOCIATION; AMYGDALA; VASOPRESSIN; EXPRESSION;
CHILDREN; POPULATION
AB Oxytocin (OXT) has been hypothesized to play a role in aetiology of autism based on a demonstrated involvement in the regulation of social behaviours. It is postulated that OXT reduces activation of the amygdala, inhibiting social anxiety, indicating a neural mechanism for the effects of OXT in social cognition. Genetic variation at the oxytocin receptor gene (OXTR) has been reported to be associated with autism. We examined 18 SNPs at the OXTR gene for association in three independent autism samples from Ireland, Portugal and the United Kingdom. We investigated cis-acting genetic effects on OXTR expression in lymphocytes and amygdala region of the brain using an allelic expression imbalance (AEI) assay and by investigating the correlation between RNA levels and genotype in the amygdala region. No marker survived multiple correction for association with autism in any sample or in a combined sample (n = 436). Results from the AEI assay performed in the lymphoblast cell lines highlighted two SNPs associated with relative allelic abundance in OXTR (rs237897 and rs237895). Two SNPs were found to be effecting cis-acting variation through AEI in the amygdala. One was weakly correlated with total gene expression (rs13316193) and the other was highlighted in the lymphoblast cell lines (rs237895). Data presented here does not support the role of common genetic variation in OXTR in the aetiology of autism spectrum disorders in Caucasian samples. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
C1 [Tansey, Katherine E.; Hill, Matthew J.; Cochrane, Lynne E.; Gill, Michael; Gallagher, Louise; Anney, Richard J. L.] Univ Ireland Trinity Coll, Dept Psychiat, Neuropsychiat Genet Res Grp, Dublin 8, Ireland.
[Brookes, Keeley J.; Kent, Lindsey] Univ St Andrews, Bute Med Sch, St Andrews KY16 9AJ, Fife, Scotland.
[Skuse, David] UCL, Inst Child Hlth, Behav & Brain Unit, London WC1E 6BT, England.
[Correia, Catarina; Vicente, Astrid] Inst Gulbenkian Ciencias, Oeiras, Portugal.
[Correia, Catarina; Vicente, Astrid] Inst Nacl Saude Dr Ricardo Jorge, Lisbon, Portugal.
[Correia, Catarina; Vicente, Astrid] Ctr Biodivers Funct & Integrat Genom, Lisbon, Portugal.
RP Tansey, KE (reprint author), Univ Ireland Trinity Coll, Dept Psychiat, Neuropsychiat Genet Res Grp, Dublin 8, Ireland.
EM tanseyk@tcd.ie
RI Hill, Matthew/E-7730-2010; Tansey, Katherine/B-1033-2013
OI Hill, Matthew/0000-0001-6776-8709; Tansey, Katherine/0000-0002-9663-3376
FU Health Research Board, Ireland; Wellcome Trust, UK; National Alliance
for Autism Research, USA
FX We thank the families who took part in this study for their support and
cooperation. Family collection in Ireland and data analysis was
supported by grants from the Health Research Board, Ireland, The
Wellcome Trust, UK, and the National Alliance for Autism Research, USA.
We would like to thank Dr. Robert Walker from the Edinburgh MRC Sudden
Death Tissue and Brain Bank for providing the brain samples.
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NR 37
TC 41
Z9 42
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
IRELAND
SN 0304-3940
J9 NEUROSCI LETT
JI Neurosci. Lett.
PD MAY 3
PY 2010
VL 474
IS 3
BP 163
EP 167
DI 10.1016/j.neulet.2010.03.035
PG 5
WC Neurosciences
SC Neurosciences & Neurology
GA 594HF
UT WOS:000277526300010
PM 20303388
ER
PT J
AU Eyles, DW
AF Eyles, Darryl W.
TI Vitamin D and autism: does skin colour modify risk?
SO ACTA PAEDIATRICA
LA English
DT Editorial Material
DE Autism; Skin pigmentation; Vitamin D
ID NUTRITIONAL RICKETS; BRAIN-DEVELOPMENT; HIGH PREVALENCE; D
INSUFFICIENCY; BLOOD SPOTS; PREGNANCY; BIRTH
C1 [Eyles, Darryl W.] Univ Queensland, Queensland Brain Inst, Brisbane, Qld 4072, Australia.
[Eyles, Darryl W.] Univ Queensland, Queensland Ctr Mental Hlth Res, Brisbane, Qld 4072, Australia.
RP Eyles, DW (reprint author), Univ Queensland, Queensland Brain Inst, Brisbane, Qld 4072, Australia.
EM eyles@uq.edu.au
CR Abrams SA, 2002, NUTR REV, V60, P111, DOI 10.1301/00296640260085840
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NR 24
TC 16
Z9 16
PU WILEY-BLACKWELL PUBLISHING, INC
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0803-5253
J9 ACTA PAEDIATR
JI Acta Paediatr.
PD MAY
PY 2010
VL 99
IS 5
BP 645
EP 647
DI 10.1111/j.1651-2227.2010.01797.x
PG 3
WC Pediatrics
SC Pediatrics
GA 575AG
UT WOS:000276034800005
PM 20219042
ER
PT J
AU Fernell, E
Barnevik-Olsson, M
Bagenholm, G
Gillberg, C
Gustafsson, S
Saaf, M
AF Fernell, Elisabeth
Barnevik-Olsson, Martina
Bagenholm, Gunnel
Gillberg, Christopher
Gustafsson, Sven
Saaf, Maria
TI Serum levels of 25-hydroxyvitamin D in mothers of Swedish and of Somali
origin who have children with and without autism
SO ACTA PAEDIATRICA
LA English
DT Article
DE Autism; 25-hydroxyvitamin D; Somali population
ID VITAMIN-D DEFICIENCY; PROTEIN EXPRESSION; BRAIN-DEVELOPMENT; SWEDEN;
RAT; SCHIZOPHRENIA; IMMIGRANTS; DISORDERS; BORN
AB Aim:
To analyse serum levels of 25-hydroxyvitamin D in mothers of Somali origin and those of Swedish origin who have children with and without autism as there is a growing evidence that low vitamin D impacts adversely on brain development.
Method:
Four groups of mothers were invited to participate; 20 with Somali origin with at least one child with autism, 20 with Somali origin without a child with autism, 20 of Swedish origin with at least one child with autism and 20 with Swedish origin without a child with autism. Two blood samples were collected from each individual; during autumn and spring.
Results:
Between 12 and 17 mothers from the different groups accepted to participate, both groups of mothers of Somali origin had significantly lower values of 25-hydroxyvitamin D compared with Swedish mothers. The difference of 25-hydroxyvitamin D between mothers of Somali origin with and without a child with autism was not significant.
Conclusion:
Our findings of low vitamin D levels in Somali women entail considerable consequences in a public health perspective. The observed tendency, i.e. the lowest values in mothers of Somali origin with a child with autism was in the predicted direction, supporting the need for further research of vitamin D levels in larger samples of Somali mothers of children with and without autism.
C1 [Fernell, Elisabeth] Autism Ctr Young Children Handicap & Habilitat, Stockholm, Sweden.
[Fernell, Elisabeth] Skaraborg Hosp, Dept Paediat, Unit Dev Disorders, S-54185 Skovde, Sweden.
[Fernell, Elisabeth] Skaraborg Hosp, FoU Ctr, S-54185 Skovde, Sweden.
[Barnevik-Olsson, Martina] PRIMA Child & Adolescent Psychiat, Stockholm, Sweden.
[Bagenholm, Gunnel] Karolinska Univ Hosp, Astrid Lindgren Childrens Hosp, Dept Paediat, Stockholm, Sweden.
[Fernell, Elisabeth; Gillberg, Christopher] Univ Gothenburg, Sahlgrenska Acad, Inst Neurosci & Physiol Child & Adolescent Psychi, Gothenburg, Sweden.
[Gustafsson, Sven] Karolinska Inst, Dept Mol Med & Surg, Stockholm, Sweden.
[Saaf, Maria] Karolinska Univ Hosp, Dept Endocrinol, Stockholm, Sweden.
RP Fernell, E (reprint author), Autism Ctr Young Children Handicap & Habilitat, S-54185 Skovde, Sweden.
EM elisabeth.fernell@karolinska.se
FU Stockholm County Council (Folkhalsoanslaget)
FX The authors are grateful to the paediatric nurses Annika Larsson and
Annika Svanberg at the Neuropaediatric Department at Astrid Lindgren
Children's Hospital, Karolinska University Hospital for the
accomplishment of all blood tests. We also thank Dr Mats Humble,
psychiatrist, for valuable discussions and for his broad knowledge in
the field.We are also indebted to Agneta Hilding at Karolinska
University Hospital for help with statistical calculations.Financial
support was given from the Stockholm County Council (Folkhalsoanslaget)
and from Odd Fellow.
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NR 26
TC 29
Z9 30
PU WILEY-BLACKWELL PUBLISHING, INC
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0803-5253
J9 ACTA PAEDIATR
JI Acta Paediatr.
PD MAY
PY 2010
VL 99
IS 5
BP 743
EP 747
DI 10.1111/j.1651-2227.2010.01755.x
PG 5
WC Pediatrics
SC Pediatrics
GA 575AG
UT WOS:000276034800024
PM 20219032
ER
PT J
AU Dealberto, MJ
AF Dealberto, M. -J.
TI Ethnic origin and increased risk for schizophrenia in immigrants to
countries of recent and longstanding immigration
SO ACTA PSYCHIATRICA SCANDINAVICA
LA English
DT Review
DE schizophrenia; immigration; ethnicity; vitamin D; autism
ID NEW-YORK-STATE; PRENATAL VITAMIN-D; MENTAL DISEASE; 1ST-CONTACT
INCIDENCE; INCIDENCE RATES; 2ND-GENERATION IMMIGRANTS;
PSYCHIATRIC-HOSPITALS; ENVIRONMENTAL-FACTORS; AFFECTIVE-DISORDERS;
CHILDHOOD AUTISM
AB Objectives: Compare the risk for schizophrenia in immigrants to countries of recent and longstanding immigration. Compare prevalence and incidence rates in black subjects under different conditions.
Method: An electronic literature search was complemented by review articles and cross-references. Studies reporting standard diagnosis and incidence or prevalence rates were included.
Results: Immigrants had an increased risk for schizophrenia in countries of longstanding immigration, but with lower risk ratios than in those of recent immigration. The risk was higher in black immigrants and the black population living in the United States. But incidence and prevalence rates in Africa and the Caribbean were similar to those of international studies.
Conclusion: Comparing the most recent generation of immigrants with descendants of previous ones may account for the lower risk ratios observed in countries of longstanding vs. recent immigration. Two neurobiological hypotheses are proposed to explain the epidemiological findings in black populations and in immigrants.
C1 Queens Univ, Dept Epidemiol & Community Hlth, Kingston, ON K7L 3N6, Canada.
RP Dealberto, MJ (reprint author), Queens Univ, Dept Epidemiol & Community Hlth, Abramsky Hall,Arch St, Kingston, ON K7L 3N6, Canada.
EM dealbert@queensu.ca
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NR 142
TC 26
Z9 26
PU WILEY-BLACKWELL PUBLISHING, INC
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0001-690X
J9 ACTA PSYCHIAT SCAND
JI Acta Psychiatr. Scand.
PD MAY
PY 2010
VL 121
IS 5
BP 325
EP 339
DI 10.1111/j.1600-0447.2009.01535.x
PG 15
WC Psychiatry
SC Psychiatry
GA 583CP
UT WOS:000276650800002
PM 20105146
ER
PT J
AU Ekas, N
Whitman, TL
AF Ekas, Naomi
Whitman, Thomas L.
TI Autism Symptom Topography and Maternal Socioemotional Functioning
SO AJIDD-AMERICAN JOURNAL ON INTELLECTUAL AND DEVELOPMENTAL DISABILITIES
LA English
DT Article
ID BEHAVIOR PROBLEMS; STRESS PROLIFERATION; SPECTRUM DISORDERS; CHILDHOOD
AUTISM; DEPRESSED MOOD; CHILDREN; MOTHERS; PARENTS; FATHERS; ASD
AB Researchers examining the relationship of autism symptomatology and maternal stress have defined symptomatology in terms of level of severity, frequency of occurrence, or symptom type. In the present study, the relationship of maternal perceptions of these dimensions, along with a fourth, symptom diversity, and negative and positive indices of maternal socioemotional functioning was evaluated. Results indicate that each of these symptom dimensions was correlated with most of the measures of negative socioemotional status, together accounting for a substantial portion of the variance in these outcomes. The dimensions were especially robust predictors of negative but not positive maternal outcomes. The need for a systematic multidimensional assessment to evaluate autism symptomatology and its social impact was discussed.
C1 [Ekas, Naomi] Univ Miami, Dept Psychol, Coral Gables, FL 33134 USA.
[Whitman, Thomas L.] Univ Notre Dame, Notre Dame, IN 46556 USA.
RP Ekas, N (reprint author), Univ Miami, Dept Psychol, Coral Gables, FL 33134 USA.
EM nekas@psy.miami.edu
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NR 38
TC 14
Z9 15
PU AMER ASSOC INTELLECTUAL DEVELOPMENTAL DISABILITIES
PI WASHINGTON
PA 444 N CAPITOL ST, NW STE 846, WASHINGTON, DC 20001-1512 USA
SN 1944-7515
J9 AJIDD-AM J INTELLECT
JI AJIDD-Am. J. Intellect. Dev. Disabil.
PD MAY
PY 2010
VL 115
IS 3
BP 234
EP 249
DI 10.1352/1944-7558-115.3.234
PG 16
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA 597SM
UT WOS:000277781600004
PM 20441393
ER
PT J
AU Ramocki, MB
Tavyev, YJ
Peters, SU
AF Ramocki, Melissa B.
Tavyev, Y. Jane
Peters, Sarika U.
TI The MECP2 Duplication Syndrome
SO AMERICAN JOURNAL OF MEDICAL GENETICS PART A
LA English
DT Review
DE MECP2; Xq28; mental retardation; autism; recurrent infections; epilepsy;
FLNA; IRAK1
ID SEVERE MENTAL-RETARDATION; CPG-BINDING PROTEIN-2; RETT-SYNDROME;
COPY-NUMBER; FILAMIN-A; PERIVENTRICULAR HETEROTOPIA; RECURRENT
INFECTIONS; CLINICAL VARIABILITY; STRUCTURAL VARIATION; GENOMIC
DISORDERS
AB In this review, we detail the history, molecular diagnosis, epidemiology, and clinical features of the MECP2 duplication syndrome, including considerations for the care of patients with this X-linked neurodevelopmental disorder. MECP2 duplication syndrome is 100% penetrant in affected males and is associated with infantile hypotonia, severe to profound mental retardation, autism or autistic features, poor speech development, recurrent infections, epilepsy, progressive spasticity, and, in some cases, developmental regression. Most of the reported cases are inherited, however, de novo cases have been documented. While carrier females have been reported to be unaffected, more recent research demonstrates that despite normal intelligence, female carriers display a range of neuropsychiatric phenotypes that predate the birth of an affected son. Given what we know of the syndrome to date, we propose that genetic testing is warranted in cases of males with infantile hypotonia and in cases of boys with mental retardation and autistic features with or without recurrent infections, progressive spasticity, epilepsy, or developmental regression. We discuss recommendations for clinical management and surveillance as well as the need for further clinical, genotype phenotype, and molecular studies to assist the patients and their families who are affected by this syndrome. (C) 2010 Wiley-Liss, Inc.
C1 [Ramocki, Melissa B.; Tavyev, Y. Jane; Peters, Sarika U.] Texas Childrens Hosp, Baylor Coll Med, Dept Pediat, Houston, TX 77030 USA.
RP Ramocki, MB (reprint author), Texas Childrens Hosp, Baylor Coll Med, Dept Pediat, 1 Baylor Plaza,MS 225,BCM T807, Houston, TX 77030 USA.
EM mramocki@bcm.edu
FU NIH/NINDS [5K08NS062711-02]; NIH General Clinical Research Center
[RR000188]
FX We are grateful to Dr. James Lupski for critical reading of this
manuscript and for helpful suggestions. We also thank Dr. Huda Zoghbi
for her unwavering mentorship and support. We are continually grateful
to the children and their families who participate in clinical research
studies, and we are specifically grateful to the families who consented
to the publication of photographs or videos of their sons. We
acknowledge the support of NIH/NINDS grant 5K08NS062711-02 (M.B.R.) and
NIH General Clinical Research Center grant RR000188.
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Z9 76
PU WILEY-LISS
PI HOBOKEN
PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 1552-4825
J9 AM J MED GENET A
JI Am. J. Med. Genet. A
PD MAY
PY 2010
VL 152A
IS 5
BP 1079
EP 1088
DI 10.1002/ajmg.a.33184
PG 10
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SC Genetics & Heredity
GA 597ES
UT WOS:000277739800004
PM 20425814
ER
PT J
AU Lindstrand, A
Malmgren, H
Verri, A
Benetti, E
Eriksson, M
Nordgren, A
Anderlid, BM
Golovleva, I
Schoumans, J
Blennow, E
AF Lindstrand, Anna
Malmgren, Helena
Verri, Annapia
Benetti, Elisa
Eriksson, Maud
Nordgren, Ann
Anderlid, Britt-Marie
Golovleva, Irina
Schoumans, Jacqueline
Blennow, Elisabeth
TI Molecular and Clinical Characterization of Patients With Overlapping 10p
Deletions
SO AMERICAN JOURNAL OF MEDICAL GENETICS PART A
LA English
DT Article
DE complex chromosomal rearrangement; cryptic deletion; chromosome 10;
fluorescence in situ hybridization; array-CGH
ID PARTIAL MONOSOMY 10P; RENAL DYSPLASIA SYNDROME; DIGEORGE-SYNDROME LOCUS;
HUMAN HDR SYNDROME; SENSORINEURAL DEAFNESS; GENOMIC REARRANGEMENTS;
BEHAVIOR CHECKLIST; CHROMOSOME 10P; ALU REPEATS; DE-NOVO
AB Chromosome 10p terminal deletions have been associated with DiGeorge phenotype, and within the same genomic region haploinsufficiency of GATA3 causes the HDR syndrome (hypoparathyroidism, sensorineural deafness, renal dysplasia). We have performed detailed molecular analysis of four patients with partial overlapping 10p deletions by using FISH-mapping, array-CGH, and custom-designed high-resolution oligonucleotide array. All four patients had mental retardation and speech impairment and three of them showed variable signs of HDR syndrome. In addition, two patients had autistic behaviors and had similar dysmorphic features giving them a striking physical resemblance. A review of the literature identified 10 previously published cases with similar 10p deletions and reliable molecular or molecular cytogenetic mapping data. The combined information of present and previous cases suggests that partial deletions of 10p14-p15 represent a syndrome with a distinct and more severe phenotype than previously assumed. The main characteristics include severe mental retardation, language impairment, autistic behavior, and characteristic clinical features. A critical region involved in mental retardation and speech impairment is defined within 1.6 Mb in 10p15.3. In addition, deletion of 4.3 Mb within 10p14 is associated with autism and characteristic clinical findings. (C) 2010 Wiley-Liss, Inc.
C1 [Lindstrand, Anna; Malmgren, Helena; Nordgren, Ann; Anderlid, Britt-Marie; Schoumans, Jacqueline; Blennow, Elisabeth] Karolinska Inst, Dept Mol Med & Surg, Clin Genet Unit, Stockholm, Sweden.
[Verri, Annapia] C Mondino Fdn, Neurol Inst, Dept Behav Neurol, Pavia, Italy.
[Benetti, Elisa] Univ Padua, Dept Pediat, Pediat Nephrol Dialysis & Transplantat Unit, Padua, Italy.
[Eriksson, Maud] Karolinska Univ Hosp, Dept Neuropediat, Stockholm, Sweden.
[Golovleva, Irina] Umea Univ Hosp, Dept Med Biosci, Med & Clin Genet Unit, S-90185 Umea, Sweden.
RP Lindstrand, A (reprint author), Karolinska Univ Hosp Solna, Dept Mol Med & Surg, Clin Genet Unit, S-17176 Stockholm, Sweden.
EM anna.lindstrand@ki.se
RI Lindstrand, Anna/J-3566-2012
OI Lindstrand, Anna/0000-0003-0806-5602
FU Swedish Medical Research Council; Stockholm County Council; Linnea and
Josef Carlsson Foundation
FX We are grateful to the patients and their parents who participated in
this study. We also thank Emma Tham for help with revision of the
English language. The work was supported by grants from the Swedish
Medical Research Council, Stockholm County Council, and the Linnea and
Josef Carlsson Foundation.
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NR 45
TC 14
Z9 14
PU WILEY-LISS
PI HOBOKEN
PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 1552-4825
J9 AM J MED GENET A
JI Am. J. Med. Genet. A
PD MAY
PY 2010
VL 152A
IS 5
BP 1233
EP 1243
DI 10.1002/ajmg.a.33366
PG 11
WC Genetics & Heredity
SC Genetics & Heredity
GA 597ES
UT WOS:000277739800018
PM 20425828
ER
PT J
AU Vazna, A
Musova, Z
Vlckova, M
Novotna, D
Dvorakova, L
Hrdlicka, M
Havlovicova, M
Sedlacek, Z
AF Vazna, Alzbeta
Musova, Zuzana
Vlckova, Marketa
Novotna, Drahuse
Dvorakova, Lenka
Hrdlicka, Michal
Havlovicova, Marketa
Sedlacek, Zdenek
TI FMR1 Gene Expansion, Large Deletion of Xp, and Skewed X-Inactivation in
a Girl With Mental Retardation and Autism
SO AMERICAN JOURNAL OF MEDICAL GENETICS PART A
LA English
DT Article
DE fragile X syndrome; Xp deletion; array CGH; skewed X-inactivation;
mental retardation; autism
ID FULL MUTATION; FEMALES; CHROMOSOME; PHENOTYPE; MICROPHTHALMIA
AB We describe a girl with mild facial anomalies, mild mental retardation, and atypical autism with a remarkable behavioral phenotype of persistent anger, aggression, and dysphoria. The occurrence of late-onset tremor and premature ovarian failure in the maternal branch of the family pointed to a possible defect in the FMR1 gene. Indeed, the patient carried a full FMR1 mutation. Unexpectedly, both alleles of the gene were almost completely methylated. Cytogenetic examination of the patient revealed in addition a large de novo deletion in band Xp22 on one of her X chromosomes. The deletion was fine mapped using oligonucleotide array CGH, and its breakpoints were localized using sequencing. The size of the deletion was about 17.4 Mb, and it contained more than 90 protein-coding genes. Microsatellite analysis indicated paternal origin of the aberrant chromosome. The large rearrangement was the most probable cause of the X-inactivation skewing, thus explaining the methylation of not only the expanded (maternal) but also the normal (paternal) FMR1 alleles. This pattern of skewed X-inactivation was confirmed using the analysis of methylation at the AR locus. The relatively mild phenotype of the patient resulted most likely from unmasking of the FMR1 defect. Although the deleted region contained many important genes, the phenotypic contribution of the rearranged X chromosome was probably limited by its almost complete inactivation. However, reduced dose of several genes escaping X-inactivation might also play a role in the phenotype of the patient. (C) 2010 Wiley-Liss, Inc.
C1 [Vazna, Alzbeta; Musova, Zuzana; Vlckova, Marketa; Novotna, Drahuse; Havlovicova, Marketa; Sedlacek, Zdenek] Charles Univ Prague, Dept Biol & Med Genet, Fac Med 2, Prague 15006 5, Czech Republic.
[Vazna, Alzbeta; Musova, Zuzana; Vlckova, Marketa; Novotna, Drahuse; Hrdlicka, Michal; Havlovicova, Marketa; Sedlacek, Zdenek] Univ Hosp Motol, Prague 15006 5, Czech Republic.
[Dvorakova, Lenka] Charles Univ Prague, Fac Med 1, Inst Inherited Metab Disorders, Prague 15006 5, Czech Republic.
[Dvorakova, Lenka] Gen Univ Hosp, Prague, Czech Republic.
[Hrdlicka, Michal] Charles Univ Prague, Dept Child Psychiat, Fac Med 2, Prague 15006 5, Czech Republic.
RP Sedlacek, Z (reprint author), Charles Univ Prague, Dept Biol & Med Genet, Fac Med 2, V Uvalu 84, Prague 15006 5, Czech Republic.
EM zdenek.sedlacek@lfmotol.cuni.cz
FU Ministries of Education and Health of the Czech Republic [NR/9457-3,
MZO00064203, MSM0021620806]; European Commission [043318, 223692]
FX This work was supported by grants NR/9457-3, MZO00064203, and
MSM0021620806 from the Ministries of Education and Health of the Czech
Republic, and INCORE (043318) and CHERISH (223692) from the European
Commission.
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NR 23
TC 3
Z9 3
PU WILEY-LISS
PI HOBOKEN
PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 1552-4825
J9 AM J MED GENET A
JI Am. J. Med. Genet. A
PD MAY
PY 2010
VL 152A
IS 5
BP 1273
EP 1277
DI 10.1002/ajmg.a.33352
PG 5
WC Genetics & Heredity
SC Genetics & Heredity
GA 597ES
UT WOS:000277739800025
PM 20425835
ER
PT J
AU Davies, PL
Tucker, R
AF Davies, Patricia L.
Tucker, Rebecca
TI Evidence Review to Investigate the Support for Subtypes of Children With
Difficulty Processing and Integrating Sensory Information
SO AMERICAN JOURNAL OF OCCUPATIONAL THERAPY
LA English
DT Review
DE classification; psychomotor performance; review; sensation disorders;
sensory integrative dysfunction; sensory processing
ID DEVELOPMENTAL COORDINATION DISORDER; ATTENTION-DEFICIT/HYPERACTIVITY
DISORDER; DEFICIT-HYPERACTIVITY DISORDER; PERCEPTUAL-MOTOR ABILITIES;
HIGH-FUNCTIONING AUTISM; LEARNING-DISABILITIES; YOUNG-CHILDREN; TYPICAL
DEVELOPMENT; SPECTRUM DISORDERS; PRESCHOOL-CHILDREN
AB We investigated the evidence for subtypes in children with difficulty processing and integrating sensory information. Fifty-seven articles were incorporated into a systematic literature review; only 4 articles provided direct evidence for subtypes. These studies did not provide a comprehensive assessment of all sensory functions and sensory-based motor functions (i.e., praxis) and included different diagnostic groups. Therefore, generalized conclusions about subtypes could not be drawn. The other 53 studies reviewed provided meaningful information about strengths and challenges that children with difficulty processing and integrating sensory information demonstrate, but these studies were limited in scope. A principal theme was the importance of conducting comprehensive assessments of sensory-based functions, including multiple measures of sensory integrative functions such as praxis, sensory modulation, and sensory discrimination in children and adolescents with various clinical disorders. In addition, more consistency in the use of specific assessment tools will allow for synthesis of data across studies.
C1 [Davies, Patricia L.] Colorado State Univ, Dept Occupat Therapy, Ft Collins, CO 80523 USA.
[Tucker, Rebecca] HCR Manor Care, Denver, CO USA.
RP Davies, PL (reprint author), Colorado State Univ, Dept Occupat Therapy, 219 Occupat Therapy, Ft Collins, CO 80523 USA.
EM pdavies@lamar.colostate.edu
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NR 75
TC 6
Z9 6
PU AMER OCCUPATIONAL THERAPY ASSOC, INC
PI BETHESDA
PA 4720 MONTGOMERY LANE, BETHESDA, MD 20814-3425 USA
SN 0272-9490
J9 AM J OCCUP THER
JI Am. J. Occup. Ther.
PD MAY-JUN
PY 2010
VL 64
IS 3
SI SI
BP 391
EP 402
DI 10.5014/ajot.2010.09070
PG 12
WC Rehabilitation
SC Rehabilitation
GA 612II
UT WOS:000278890500004
PM 20608271
ER
PT J
AU May-Benson, TA
Koomar, JA
AF May-Benson, Teresa A.
Koomar, Jane A.
TI Systematic Review of the Research Evidence Examining the Effectiveness
of Interventions Using a Sensory Integrative Approach for Children
SO AMERICAN JOURNAL OF OCCUPATIONAL THERAPY
LA English
DT Review
DE activities of daily living; evidence-based practice; pediatrics; review;
sensory integrative therapy; treatment outcome
ID LEARNING-DISABLED CHILDREN; OCCUPATIONAL-THERAPY; MODULATION DISORDER;
NYSTAGMUS DURATION; DISABILITIES; EFFICACY; TRIAL; COORDINATION;
OUTCOMES; AUTISM
AB Twenty-seven studies were systematically reviewed to identify, evaluate, and synthesize the research literature On the effectiveness of sensory integration (SI) intervention on the ability of children with difficulty processing and integrating sensory information to engage in desired occupations and to apply these findings to occupational therapy practice. Results suggest the SI approach may result in positive outcomes in sensorimotor skills and motor planning; socialization, attention, and behavioral regulation; reading-related skills; participation in active play; and achievement of individualized goals. Gross motor skills, self-esteem, and reading gains may be sustained from 3 mo to 2 yr. Findings may be limited by Type II error because of small sample sizes, variable intervention dosage, lack of fidelity to intervention, and selection of outcomes that may not be meaningful to clients and families or may not change with amount of treatment provided. Replication of findings with methodologically and theoretically sound studies is needed to support current findings.
C1 [May-Benson, Teresa A.; Koomar, Jane A.] Spiral Fdn, Watertown, MA 02472 USA.
[May-Benson, Teresa A.; Koomar, Jane A.] OTA Watertown, Watertown, MA 02472 USA.
RP May-Benson, TA (reprint author), Spiral Fdn, 124 Watertown St, Watertown, MA 02472 USA.
EM tmay-benson@alum.bu.edu
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NR 55
TC 35
Z9 36
PU AMER OCCUPATIONAL THERAPY ASSOC, INC
PI BETHESDA
PA 4720 MONTGOMERY LANE, BETHESDA, MD 20814-3425 USA
SN 0272-9490
J9 AM J OCCUP THER
JI Am. J. Occup. Ther.
PD MAY-JUN
PY 2010
VL 64
IS 3
SI SI
BP 403
EP 414
DI 10.5014/ajot.2010.09071
PG 12
WC Rehabilitation
SC Rehabilitation
GA 612II
UT WOS:000278890500005
PM 20608272
ER
PT J
AU Polatajko, HJ
Cantin, N
AF Polatajko, Helene J.
Cantin, Noemi
TI Exploring the Effectiveness of Occupational Therapy Interventions, Other
Than the Sensory Integration Approach, With Children and Adolescents
Experiencing Difficulty Processing and Integrating Sensory Information
SO AMERICAN JOURNAL OF OCCUPATIONAL THERAPY
LA English
DT Article
DE activities of daily living; occupational therapy; pediatrics; review;
sensory integrative dysfunction; sensory processing; treatment outcome
ID DEVELOPMENTAL COORDINATION DISORDER; WEIGHTED VEST; BALANCE BEAM;
AUTISM; ATTENTION; EFFICACY; BEHAVIOR; TASK
AB This literature review was completed as part of the Evidence-Based Literature Review Project of the American Occupational Therapy Association to explore the effectiveness of occupational therapy interventions with children and adolescents experiencing difficulty processing and integrating sensory information. This part of the review focused on interventions other than the sensory integration approach. Twenty articles (reporting on 21 studies) met the inclusion criteria. This systematic review found that children with difficulty processing and integrating sensory information and difficulties with the performance of daily occupations can benefit from intervention. However, the great variability that characterizes this literature in terms of populations, interventions, and study quality precludes the formation of any firm conclusions regarding specific approaches. There is an urgent need for well-controlled studies examining the effectiveness of frequently used pediatric occupational therapy interventions with well-defined, homogeneous populations on outcomes that target participation in everyday life.
C1 [Polatajko, Helene J.] Univ Toronto, Fac Med, Dept Occupat Therapy, Toronto, ON M5G 1V7, Canada.
[Cantin, Noemi] Univ Toronto, Fac Med, Dept Rehabil Sci, Toronto, ON M5G 1V7, Canada.
RP Polatajko, HJ (reprint author), Univ Toronto, Fac Med, Dept Occupat Therapy, 160-500 Univ Ave, Toronto, ON M5G 1V7, Canada.
EM h.polatajko@utoronto.ca
CR Arbesman M, 2010, AM J OCCUP THER, V64, P368, DOI 10.5014/ajot.2010.09068
AYRES AJ, 1979, SENSE INTEGRATION CH
Baranek GT, 2002, J AUTISM DEV DISORD, V32, P397, DOI 10.1023/A:1020541906063
Candler Catherine, 2003, Physical & Occupational Therapy in Pediatrics, V23, P51, DOI 10.1300/J006v23n03_04
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World Health Organisation, 2001, INT CLASS FUNCT DIS
NR 31
TC 14
Z9 14
PU AMER OCCUPATIONAL THERAPY ASSOC, INC
PI BETHESDA
PA 4720 MONTGOMERY LANE, BETHESDA, MD 20814-3425 USA
SN 0272-9490
J9 AM J OCCUP THER
JI Am. J. Occup. Ther.
PD MAY-JUN
PY 2010
VL 64
IS 3
SI SI
BP 415
EP 429
DI 10.5014/ajot.2010.09072
PG 15
WC Rehabilitation
SC Rehabilitation
GA 612II
UT WOS:000278890500006
PM 20608273
ER
PT J
AU Koenig, KP
Rudney, SG
AF Koenig, Kristie Patten
Rudney, Sarah G.
TI Performance Challenges for Children and Adolescents With Difficulty
Processing and Integrating Sensory Information: A Systematic Review
SO AMERICAN JOURNAL OF OCCUPATIONAL THERAPY
LA English
DT Review
DE activities of daily living; human activities; pediatrics; review;
sensory integrative dysfunction; sensory processing
ID DEVELOPMENTAL COORDINATION DISORDER; HIGH-FUNCTIONING AUTISM;
SCHOOL-AGED CHILDREN; ASPERGERS-DISORDER; YOUNG-CHILDREN; OCCUPATIONAL
PERFORMANCE; SPECTRUM DISORDERS; SOCIAL-BEHAVIOR; SELF-REGULATION; SLEEP
PATTERNS
AB A systematic review of the literature related to performance difficulties for children and adolescents with difficulty processing and integrating sensory information was completed as part of the Evidence-Based Literature Review Project of the American Occupational Therapy Association. The review focused on functional performance difficulties that these children may exhibit in areas of occupation including play and leisure, social participation, activities of daily living, instrumental activities of daily living, rest and sleep, education, and work. The results suggest that children and adolescents with difficulty processing and integrating sensory information do exhibit functional performance difficulties in key areas of occupation. However, further descriptive studies are needed to tie these difficulties to their specific sensory and motor issues. Researchers are encouraged to include functional performance measures and measures of social participation in their studies to further elucidate these relationships.
C1 [Koenig, Kristie Patten] NYU, Steinhardt Sch Culture Human Dev & Educ, Dept Occupat Therapy, New York, NY 10012 USA.
[Rudney, Sarah G.] Important Steps Inc, New York, NY USA.
RP Koenig, KP (reprint author), NYU, Steinhardt Sch Culture Human Dev & Educ, Dept Occupat Therapy, 35 W 4th St,11th Floor, New York, NY 10012 USA.
EM kpk3@nyu.edu
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American Occupational Therapy Association, 2008, AM J OCCUPATIONAL TH, V62, P625, DOI [10.5014/ajot.62.6.625, DOI 10.5014/AJOT.62.6.625]
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NR 56
TC 9
Z9 9
PU AMER OCCUPATIONAL THERAPY ASSOC, INC
PI BETHESDA
PA 4720 MONTGOMERY LANE, BETHESDA, MD 20814-3425 USA
SN 0272-9490
J9 AM J OCCUP THER
JI Am. J. Occup. Ther.
PD MAY-JUN
PY 2010
VL 64
IS 3
SI SI
BP 430
EP 442
DI 10.5014/ajot.2010.09073
PG 13
WC Rehabilitation
SC Rehabilitation
GA 612II
UT WOS:000278890500007
PM 20608274
ER
PT J
AU Gal, E
Dyck, MJ
Passmore, A
AF Gal, Eynat
Dyck, Murray J.
Passmore, Anne
TI Relationships Between Stereotyped Movements and Sensory Processing
Disorders in Children With and Without Developmental or Sensory
Disorders
SO AMERICAN JOURNAL OF OCCUPATIONAL THERAPY
LA English
DT Article
DE autistic disorder; developmental disabilities; hearing disorders;
sensory integrative dysfunction; sensory processing; stereotypic
movement disorder; visual disorders
ID SELF-INJURIOUS-BEHAVIOR; AUTISM; INTEGRATION; DYSFUNCTION; EXPERIENCE;
ATTENTION; INFANTS; PROFILE; MOTOR
AB OBJECTIVE. Stereotyped movements (SM) are a defining characteristic of autism but are also present in children with a range of sensory and developmental disorders. We examined whether the severity of sensory processing disorders (SPD) was associated with the severity of SM and whether SPD accounted for between-group differences in SM.
METHOD. The Short Sensory Profile and the Stereotyped and Self-Injurious Movements Interview were administered to children with autism, intellectual disability, visual impairment, and hearing impairment and to typically developing children.
RESULTS. SPD predicted the severity of SM in all samples and accounted for differences in SM between the groups. Other differences in the severity of SM were the result of diagnosis and the interaction between diagnosis and an intellectual disability.
CONCLUSION. SPD may be a source of SM, but functional connections between these phenomena will need to be tested in future research. Implications for occupational performance are addressed.
C1 [Gal, Eynat] Univ Haifa, Dept Occupat Therapy, IL-31905 Haifa, Israel.
[Dyck, Murray J.] Griffith Univ, Sch Psychol, Gold Coast, Australia.
[Passmore, Anne] Curtin Univ Technol, Sch Occupat Therapy & Social Work, Curtin Hlth Innovat Res Inst, Ctr Res Disabil & Soc, Curtin, WA, Australia.
RP Gal, E (reprint author), Univ Haifa, Dept Occupat Therapy, IL-31905 Haifa, Israel.
EM eynatgal@gmail.com
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White BP, 2007, AM J OCCUP THER, V61, P154
NR 50
TC 8
Z9 8
PU AMER OCCUPATIONAL THERAPY ASSOC, INC
PI BETHESDA
PA 4720 MONTGOMERY LANE, BETHESDA, MD 20814-3425 USA
SN 0272-9490
J9 AM J OCCUP THER
JI Am. J. Occup. Ther.
PD MAY-JUN
PY 2010
VL 64
IS 3
SI SI
BP 453
EP 461
DI 10.5014/ajot.2010.09075
PG 9
WC Rehabilitation
SC Rehabilitation
GA 612II
UT WOS:000278890500009
PM 20608276
ER
PT J
AU Cosbey, J
Johnston, SS
Dunn, ML
AF Cosbey, Joanna
Johnston, Susan S.
Dunn, M. Louise
TI Sensory Processing Disorders and Social Participation
SO AMERICAN JOURNAL OF OCCUPATIONAL THERAPY
LA English
DT Article
DE human activities; interpersonal relations; sensory integrative
dysfunction; sensory processing; social behavior
ID DAILY-LIFE; CHILDREN; DYSFUNCTION; ADHD; IMPAIRMENT; ATTENTION;
RESPONSES; PATTERNS; CONTEXT; AUTISM
AB Participation in social aspects of daily life is crucial to children's development. Although disability status is recognized to affect children's ability to participate in social activities, little is understood about the impact of sensory processing disorders (SPD) on children's social participation. We examined the social participation patterns of 2 groups of children (ages 6-9): (1) children with SPD and (2) their typically developing peers. All children participated in a structured interview to report their social participation patterns, including activity patterns and social networks. We used parent and teacher questionnaires to triangulate the data gathered from the children. Results revealed that the 2 groups of children demonstrated generally similar patterns of activity preferences and use of free time but had significant differences in areas related to intensity and enjoyment of involvement and in their social networks. Implications for future research and interventions are discussed.
C1 [Cosbey, Joanna] Univ New Mexico, Special Educ Program, Dept Educ Specialties, Albuquerque, NM 87131 USA.
[Johnston, Susan S.] Univ Utah, Dept Special Educ, Salt Lake City, UT 84112 USA.
[Dunn, M. Louise] Univ Utah, Div Occupat Therapy, Salt Lake City, UT 84112 USA.
RP Cosbey, J (reprint author), Univ New Mexico, Special Educ Program, Dept Educ Specialties, Hokona Hall Room 282,MSC05 3040,1 Univ New Mexico, Albuquerque, NM 87131 USA.
EM jcosbey@unm.edu
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American Occupational Therapy Association, 2008, AM J OCCUPATIONAL TH, V62, P707
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World Health Organisation, 2001, INT CLASS FUNCT DIS
Yochman A, 2004, AM J OCCUP THER, V58, P294
NR 44
TC 16
Z9 16
PU AMER OCCUPATIONAL THERAPY ASSOC, INC
PI BETHESDA
PA 4720 MONTGOMERY LANE, BETHESDA, MD 20814-3425 USA
SN 0272-9490
J9 AM J OCCUP THER
JI Am. J. Occup. Ther.
PD MAY-JUN
PY 2010
VL 64
IS 3
SI SI
BP 462
EP 473
DI 10.5014/ajot.2010.09076
PG 12
WC Rehabilitation
SC Rehabilitation
GA 612II
UT WOS:000278890500010
PM 20608277
ER
PT J
AU Brown, NB
Dunn, W
AF Brown, Natalie Bennett
Dunn, Winnie
TI Relationship Between Context and Sensory Processing in Children With
Autism
SO AMERICAN JOURNAL OF OCCUPATIONAL THERAPY
LA English
DT Article
DE autistic disorder; child behavior; environment; sensory processing;
sensory threshold
ID DEVELOPMENTAL DISORDERS; OCCUPATIONAL-THERAPY; YOUNG-CHILDREN; PROFILE;
PERFORMANCE; SCHOOL; FRAMEWORK; PARENTS
AB OBJECTIVE. The purpose of the study was to determine the relationship between sensory processing and context for children with autism. We examined home and school contexts using the Sensory Profile (Dunn, 1999) and the Sensory Profile School Companion (Dunn, 2006a) questionnaires.
METHOD. Teachers of 49 students with autism completed the Sensory Profile School Companion, and parents completed the Sensory Profile. We conducted correlational analyses using the avoiding and seeking quadrant scores from the School Companion and corresponding avoiding and seeking quadrant scores from the Sensory Profile.
RESULTS. The avoiding quadrant score coefficient (.59) and the seeking quadrant score coefficient (.45) were statistically significant (p = .01) with good and fair correlations, respectively, suggesting that sensory processing patterns have both universal qualities and context-specific qualities in children with autism.
CONCLUSION. Findings from this study provide initial evidence that sensory processing and context for children with autism are related.
C1 [Brown, Natalie Bennett] The Manse, London NW8 9PU, England.
[Dunn, Winnie] Univ Kansas, Med Ctr, Dept Occupat Therapy Educ, Lawrence, KS 66045 USA.
RP Brown, NB (reprint author), The Manse, 9 Hamilton Gardens, London NW8 9PU, England.
EM tallybennett@yahoo.com
CR ACHENBACH TM, 1987, PSYCHOL BULL, V101, P213, DOI 10.1037/0033-2909.101.2.213
American Psychiatric Association, 2000, DIAGN STAT MAN MENT
Ayres AJ, 1979, SENSORY INTEGRATION
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NR 36
TC 10
Z9 10
PU AMER OCCUPATIONAL THERAPY ASSOC, INC
PI BETHESDA
PA 4720 MONTGOMERY LANE, BETHESDA, MD 20814-3425 USA
SN 0272-9490
J9 AM J OCCUP THER
JI Am. J. Occup. Ther.
PD MAY-JUN
PY 2010
VL 64
IS 3
SI SI
BP 474
EP 483
DI 10.5014/ajot.2010.09077
PG 10
WC Rehabilitation
SC Rehabilitation
GA 612II
UT WOS:000278890500011
PM 20608278
ER
PT J
AU Tu, ZD
Cohen, M
Bu, H
Lin, F
AF Tu, Zhidan
Cohen, Mark
Bu, Hong
Lin, Feng
TI Tissue Distribution and Functional Analysis of Sushi Domain-Containing
Protein 4
SO AMERICAN JOURNAL OF PATHOLOGY
LA English
DT Article
ID DECAY-ACCELERATING FACTOR; FRYNS-SYNDROME; COMPLEMENT ACTIVATION;
ESCHERICHIA-COLI; RECEPTOR; MICE; INHIBITION; PROTECTION; DEFICIENT;
DISCOVERY
AB Sushi domain-containing protein 4 (SUSD4) was a hypothetical cell surface protein whose tissue distribution and function were completely unknown. However, recent microarray-based studies have identified deletions of SUSD4 gene in patients with autism or Fryns syndrome, both of which are genetic diseases with severe abnormal neurological development and/or functions. In this article, we described the cloning, expression, refolding, tissue distribution, and functional analysis of this novel protein. Using polyclonal antibodies generated by immunizing chickens with the recombinant SUSD4, we found that SUSD4 is detectable in murine brains, eyes, spinal cords, and testis but not other tissues. In brains, SUSD4 is highly expressed in the white matter on oligodendrocytes/axons, and in eyes, it is exclusively expressed on the photoreceptor outer segments. In in vitro complement assays, SUSD4 augments the alternative but not the classical pathway of complement activation at the C3 convertase step. In in vivo studies, knocking down SUSD4 expression in zebrafish markedly increases ratios of mortality and developmental abnormality. These results provide the first insight into the important physiological roles of SUSD4 and could help to better understand the pathogenesis of autism and Fryns syndrome. (Am J Pathol 2010, 176:2378-2384; DOI: 10.2353/ajpath.2010.091036)
C1 [Lin, Feng] Case Western Reserve Univ, Sch Med, Inst Pathol, Dept Pathol, Cleveland, OH 44106 USA.
[Tu, Zhidan; Bu, Hong] Sichuan Univ, W China Hosp, Dept Pathol, Chengdu 610041, Peoples R China.
RP Lin, F (reprint author), Case Western Reserve Univ, Sch Med, Inst Pathol, Dept Pathol, 2085 Adelbert Rd,Room 306, Cleveland, OH 44106 USA.
EM hongbu@scu.edu.cn; feng.lin@case.edu
FU National Institutes of Health [NS052471, EY11373]; National Multiple
Sclerosis Society [RG3664]; Natural Science Foundation of China
[30671988]; Chinese Oversea Postgraduate Program [3019-2008624057]
FX Supported by National Institutes of Health (grants NS052471 to F.L. and
EY11373 to Vision Science Research Center), National Multiple Sclerosis
Society (grant RG3664 to F.L.), Natural Science Foundation of China
(grant 30671988 to H.B.), and the Chinese Oversea Postgraduate Program
Fellowship (grant 3019-2008624057 to Z.T.).
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NR 30
TC 3
Z9 3
PU AMER SOC INVESTIGATIVE PATHOLOGY, INC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3993 USA
SN 0002-9440
J9 AM J PATHOL
JI Am. J. Pathol.
PD MAY
PY 2010
VL 176
IS 5
BP 2378
EP 2384
DI 10.2353/ajpath.2010.091036
PG 7
WC Pathology
SC Pathology
GA 627XV
UT WOS:000280078600032
PM 20348246
ER
PT J
AU Reichenberg, A
Cross, R
Sandin, S
Susser, ES
AF Reichenberg, Abraham
Cross, Raz
Sandin, Sven
Susser, Ezra S.
TI ADVANCING PATERNAL AND MATERNAL AGE ARE BOTH IMPORTANT FOR AUTISM RISK
SO AMERICAN JOURNAL OF PUBLIC HEALTH
LA English
DT Letter
C1 [Reichenberg, Abraham] Kings Coll London, Inst Psychiat, Dept Psychosis Studies, London SE5 8AF, England.
[Cross, Raz; Susser, Ezra S.] Columbia Univ, Dept Epidemiol, Mailman Sch Publ Hlth, New York, NY USA.
[Cross, Raz; Susser, Ezra S.] New York State Psychiat Inst & Hosp, New York, NY 10032 USA.
[Sandin, Sven] Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden.
RP Reichenberg, A (reprint author), Kings Coll London, Inst Psychiat, Dept Psychosis Studies, Denmark Hill Campus, London SE5 8AF, England.
EM avi.reichenberg@kcl.ac.uk
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Kolevzon A, 2007, ARCH PEDIAT ADOL MED, V161, P326, DOI 10.1001/archpedi.161.4.326
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NR 9
TC 10
Z9 11
PU AMER PUBLIC HEALTH ASSOC INC
PI WASHINGTON
PA 800 I STREET, NW, WASHINGTON, DC 20001-3710 USA
SN 0090-0036
J9 AM J PUBLIC HEALTH
JI Am. J. Public Health
PD MAY
PY 2010
VL 100
IS 5
BP 772
EP 773
DI 10.2105/AJPH.2009.187708
PG 2
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 585ME
UT WOS:000276828800001
PM 20299637
ER
PT J
AU King, M
Bearman, P
AF King, Marissa
Bearman, Peter
TI ADVANCING PATERNAL AND MATERNAL AGE ARE BOTH IMPORTANT FOR AUTISM RISK
KING AND BEARMAN RESPOND
SO AMERICAN JOURNAL OF PUBLIC HEALTH
LA English
DT Letter
C1 [King, Marissa; Bearman, Peter] Columbia Univ, Paul L Lazarsfeld Ctr Social Sci, New York, NY 10027 USA.
RP King, M (reprint author), Columbia Univ, Paul L Lazarsfeld Ctr Social Sci, 420 W 118th St, New York, NY 10027 USA.
EM mdk2101@columbia.edu
CR Grether JK, 2009, AM J EPIDEMIOL, V170, P1118, DOI 10.1093/aje/kwp247
King MD, 2009, AM J PUBLIC HEALTH, V99, P1673, DOI 10.2105/AJPH.2008.149021
Lauritsen MB, 2005, J CHILD PSYCHOL PSYC, V46, P963, DOI 10.1111/j.1469-7610.2004.00391.x
NR 3
TC 0
Z9 0
PU AMER PUBLIC HEALTH ASSOC INC
PI WASHINGTON
PA 800 I STREET, NW, WASHINGTON, DC 20001-3710 USA
SN 0090-0036
J9 AM J PUBLIC HEALTH
JI Am. J. Public Health
PD MAY
PY 2010
VL 100
IS 5
BP 773
EP 773
DI 10.2105/AJPH.2009.187880
PG 1
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 585ME
UT WOS:000276828800002
ER
PT J
AU Flenthrope, JL
Brady, NC
AF Flenthrope, Jennifer L.
Brady, Nancy C.
TI Relationships Between Early Gestures and Later Language in Children With
Fragile X Syndrome
SO AMERICAN JOURNAL OF SPEECH-LANGUAGE PATHOLOGY
LA English
DT Article
DE fragile X; gestural communication; autism spectrum disorders
ID AUTISM SPECTRUM DISORDERS; COMMUNICATION PROFILES; YOUNG MALES; 2ND
YEAR; INFANTS; LIFE
AB Purpose: The authors hypothesized that significant positive relationships would exist between early gesture use and later language attainments in children with fragile X syndrome (FXS), as has been reported in studies with other populations.
Method: Participants were young children with FXS and limited expressive language (21 boys, 4 girls), divided into 2 subgroups based on the Childhood Autism Rating Scale (CARS; Schopler, Reichler, & Renner, 1988) scores. Data were collected when participants were about 2 years of age and again when they were about 5 years of age. Communication was assessed through the analysis of video samples obtained in the children's homes for both observation periods. Correlational analyses were completed between early prelinguistic communication and later verbal communication scores for all participants and for children with high (>30) versus low (<30) scores on the CARS.
Results: Although no significant relationships were found between prelinguistic gesture use and language outcomes for the group of children as a whole, significant negative correlations were found for the group of children who had high CARS scores.
Conclusions: These outcomes did not support the authors' initial hypotheses. It was concluded that extensive use of developmentally early gestures by children with FXS who also have many symptoms of autism may not be a positive indicator of later language.
C1 [Brady, Nancy C.] Univ Kansas, Dept Speech Language Hearing Sci & Disorders, Lawrence, KS 66045 USA.
RP Brady, NC (reprint author), Univ Kansas, Dept Speech Language Hearing Sci & Disorders, 1000 Sunnyside Dr, Lawrence, KS 66045 USA.
EM nbrady@ku.edu
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NR 30
TC 4
Z9 4
PU AMER SPEECH-LANGUAGE-HEARING ASSOC
PI ROCKVILLE
PA 10801 ROCKVILLE PIKE, ROCKVILLE, MD 20852-3279 USA
SN 1058-0360
J9 AM J SPEECH-LANG PAT
JI Am. J. Speech-Lang. Pathol.
PD MAY 1
PY 2010
VL 19
IS 2
BP 135
EP 142
DI 10.1044/1058-0360(2009/09-0018)
PG 8
WC Audiology & Speech-Language Pathology; Linguistics; Rehabilitation
SC Audiology & Speech-Language Pathology; Linguistics; Rehabilitation
GA 622OS
UT WOS:000279673700005
PM 19948762
ER
PT J
AU Flippin, M
Reszka, S
Watson, LR
AF Flippin, Michelle
Reszka, Stephanie
Watson, Linda R.
TI Effectiveness of the Picture Exchange Communication System (PECS) on
Communication and Speech for Children With Autism Spectrum Disorders: A
Meta-Analysis
SO AMERICAN JOURNAL OF SPEECH-LANGUAGE PATHOLOGY
LA English
DT Article
DE autism; Picture Exchange Communication System; communication
intervention; speech
ID SINGLE-SUBJECT RESEARCH; SEVERE DEVELOPMENTAL-DISABILITIES;
SPECIAL-EDUCATION; YOUNG-CHILDREN; PHASE-III; INTERVENTIONS;
PRESCHOOLERS; ACQUISITION; BEHAVIOR; ADULTS
AB Purpose: The Picture Exchange Communication System (PECS) is a popular communication-training program for young children with autism spectrum disorders (ASD). This meta-analysis reviews the current empirical evidence for PECS in affecting communication and speech outcomes for children with ASD.
Method: A systematic review of the literature on PECS written between 1994 and June 2009 was conducted. Quality of scientific rigor was assessed and used as an inclusion criterion in computation of effect sizes. Effect sizes were aggregated separately for single-subject and group studies for communication and speech outcomes.
Results: Eight single-subject experiments (18 participants) and 3 group studies (95 PECS participants, 65 in other intervention/control) were included. Results indicated that PECS is a promising but not yet established evidence-based intervention for facilitating communication in children with ASD ages 1-11 years. Small to moderate gains in communication were demonstrated following training. Gains in speech were small to negative.
Conclusions: This meta-analysis synthesizes gains in communication and relative lack of gains made in speech across the PECS literature for children with ASD. Concerns about maintenance and generalization are identified. Emerging evidence of potential preintervention child characteristics is discussed. Phase IV was identified as a possibly influential program characteristic for speech outcomes.
C1 [Flippin, Michelle] Univ N Carolina, Chapel Hill Div Speech & Hearing Sci, Chapel Hill, NC 27599 USA.
RP Flippin, M (reprint author), Univ N Carolina, Chapel Hill Div Speech & Hearing Sci, Bondurant Hall,CB 7190, Chapel Hill, NC 27599 USA.
EM mflippin@unc.edu
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NR 72
TC 28
Z9 30
PU AMER SPEECH-LANGUAGE-HEARING ASSOC
PI ROCKVILLE
PA 10801 ROCKVILLE PIKE, ROCKVILLE, MD 20852-3279 USA
SN 1058-0360
J9 AM J SPEECH-LANG PAT
JI Am. J. Speech-Lang. Pathol.
PD MAY 1
PY 2010
VL 19
IS 2
BP 178
EP 195
DI 10.1044/1058-0360(2010/09-0022)
PG 18
WC Audiology & Speech-Language Pathology; Linguistics; Rehabilitation
SC Audiology & Speech-Language Pathology; Linguistics; Rehabilitation
GA 622OS
UT WOS:000279673700009
PM 20181849
ER
PT J
AU Yoon, JMD
Tennie, C
AF Yoon, Jennifer M. D.
Tennie, Claudio
TI Contagious yawning: a reflection of empathy, mimicry, or contagion?
SO ANIMAL BEHAVIOUR
LA English
DT Editorial Material
DE Canis familiaris; chameleon effect; contagion; dog; empathy; mimicry;
primate; social cognition; selective breeding; yawning
ID DOGS; AFFILIATION; AUTISM; HUMANS
C1 [Yoon, Jennifer M. D.] Stanford Univ, Dept Psychol, Stanford, CA 94305 USA.
[Tennie, Claudio] Max Planck Inst Evolutionary Anthropol, Dept Dev & Comparat Psychol, D-04103 Leipzig, Germany.
RP Yoon, JMD (reprint author), Stanford Univ, Dept Psychol, Stanford, CA 94305 USA.
EM jennifer.yoon@stanford.edu
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NR 19
TC 13
Z9 13
PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 0003-3472
J9 ANIM BEHAV
JI Anim. Behav.
PD MAY
PY 2010
VL 79
IS 5
BP E1
EP E3
DI 10.1016/j.anbehav.2010.02.011
PG 3
WC Behavioral Sciences; Zoology
SC Behavioral Sciences; Zoology
GA 585GB
UT WOS:000276811500026
ER
PT J
AU Brown, J
Kaplan, G
Rogers, LJ
Vallortigara, G
AF Brown, J.
Kaplan, G.
Rogers, L. J.
Vallortigara, G.
TI Perception of biological motion in common marmosets (Callithrix
jacchus): by females only
SO ANIMAL COGNITION
LA English
DT Article
DE Common marmoset; Biological motion; Sex difference; Moving dot patterns
ID POINT-LIGHT DISPLAYS; BIOMECHANICAL MOTIONS; RECOGNITION; INFANTS;
COLOR; DISCRIMINATION; ADVANTAGE; STIMULI; MONKEYS; AUTISM
AB The ability to perceive biological motion (BM) has been demonstrated in a number of species including humans but the few studies of non-human primates have been relatively inconclusive. We investigated whether common marmosets (Callithrix jacchus) are able to perceive biological motion, using a novel method to test non-human primates. Marmosets (7 male and 7 female) were trained to remove a cover from a container and look inside it, revealing a computer screen. Then they were presented with images on this computer screen consisting of a novel BM pattern (a walking hen) and 4 manipulations of that pattern (a static frame of this pattern and inverted, scrambled, and rotating versions of the pattern). The behavioural responses of the marmosets were recorded and used to assess discrimination between stimuli. BM was attended to by females but not males, as shown by active inspection behaviour, mainly movement of the head towards the stimulus. Females paid significantly less attention to all of the other stimuli. This indicates the females' ability to attend to biological motion. Females showed slightly more attention to the inverted BM than to the static, scrambled, and rotating patterns. The males were less attentive to all of the stimuli than were the females and, unlike the females, responded to all stimuli in a similar manner. This sex difference could be due to an inability of males to recognise BM altogether or to a lesser amount of curiosity. Considered together with the findings of previous studies on chicks and humans, the results of the present study support the notion of a common mechanism across species for the detection of BM.
C1 [Brown, J.; Kaplan, G.; Rogers, L. J.; Vallortigara, G.] Univ New England, Sch Sci & Technol, Ctr Neurosci & Anim Behav, Armidale, NSW 2351, Australia.
[Vallortigara, G.] Univ Trent, Ctr Mind Brain Sci, I-38068 Rovereto, Italy.
RP Kaplan, G (reprint author), Univ New England, Sch Sci & Technol, Ctr Neurosci & Anim Behav, Armidale, NSW 2351, Australia.
EM julian.brown20@yahoo.com; gkaplan@une.edu.au
FU Australian Research Council
FX We are grateful to the Australian Research Council for funding to L.J.R.
in support of the marmoset colony at UNE. This project was part of the
requirements of J.B.'s Honours degree at the University of New England.
The housing and testing conditions of the marmosets were in accordance
with the principles and regulations of the Australian Code of Practice
for the Care and Use of Animals for Scientific Purposes (1997) and
approved by the Animal Ethics committee at the University of New England
(AEC08/037).
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NR 42
TC 10
Z9 10
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1435-9448
J9 ANIM COGN
JI Anim. Cogn.
PD MAY
PY 2010
VL 13
IS 3
BP 555
EP 564
DI 10.1007/s10071-009-0306-0
PG 10
WC Behavioral Sciences; Zoology
SC Behavioral Sciences; Zoology
GA 582NC
UT WOS:000276603500016
PM 20052512
ER
PT J
AU Bos, KJ
Zeanah, CH
Smyke, AT
Fox, NA
Nelson, CA
AF Bos, Karen J.
Zeanah, Charles H., Jr.
Smyke, Anna T.
Fox, Nathan A.
Nelson, Charles A., III
TI Stereotypies in Children With a History of Early Institutional Care
SO ARCHIVES OF PEDIATRICS & ADOLESCENT MEDICINE
LA English
DT Article
ID EARLY INTERVENTION PROJECT; EARLY EXPERIENCE; YOUNG-CHILDREN;
DEPRIVATION; DISORDERS; BEHAVIOR; BRAIN; AUTISM
AB Objectives: To investigate the prevalence of stereotypies in children with a history of early institutional care, evaluate the efficacy of a foster care intervention compared with institutional care on the course of stereotypies, and describe correlates in language, cognition, and anxiety for children who exhibit stereotypies.
Design: Randomized controlled trial.
Setting: Institutions in Bucharest, Romania.
Participants: One hundred thirty-six children with a history of early institutional care.
Intervention: Comparison of a foster care intervention with continued care as usual in an institution.
Main Outcome Measures: The presence of stereotypies as well as outcomes in language, cognition, and anxiety.
Results: At the baseline assessment prior to placement in foster care (average age of 22 months), more than 60% of children in institutional care exhibited stereotypies. Follow-up assessments at 30 months, 42 months, and 54 months indicated that being placed in families significantly reduced stereotypies, and with earlier and longer placements, reductions became larger. For children in the foster care group, but not in the care as usual group, stereotypies were significantly associated with lower outcomes on measures of language and cognition.
Conclusions: Stereotypies are prevalent in children with a history of institutional care. A foster care intervention appears to have a beneficial/moderating role on reducing stereotypies, underscoring the need for early placement in home based care for abandoned children. Children who continue to exhibit stereotypies after foster care placement are significantly more impaired on outcomes of language and cognition than children without stereotypies and thus may be a target for further assessments or interventions.
C1 [Bos, Karen J.; Nelson, Charles A., III] Harvard Univ, Sch Med, Childrens Hosp Boston, Cognit Neurosci Lab, Boston, MA 02115 USA.
[Fox, Nathan A.] Univ Maryland, Dept Human Dev, College Pk, MD 20742 USA.
[Zeanah, Charles H., Jr.; Smyke, Anna T.] Tulane Univ, Dept Psychiat & Behav Sci, New Orleans, LA 70118 USA.
RP Nelson, CA (reprint author), Harvard Univ, Sch Med, Childrens Hosp Boston, Cognit Neurosci Lab, 1 Autumn St,Off AU621,Mailbox 713, Boston, MA 02115 USA.
EM charles.nelson@childrens.harvard.edu
FU John D. and Catherine T. MacArthur Foundation; Binder Family Foundation;
Richard David Scott Chair; Doris Duke Charitable Foundation
FX Funding/Support: The work reported in this article was supported by the
John D. and Catherine T. MacArthur Foundation, the Binder Family
Foundation, the Richard David Scott Chair (Dr Nelson), and the Doris
Duke Charitable Foundation (Ms Bos).
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2000, WECHSLER PRESCHOOL P
NR 28
TC 18
Z9 19
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 515 N STATE ST, CHICAGO, IL 60610-0946 USA
SN 1072-4710
J9 ARCH PEDIAT ADOL MED
JI Arch. Pediatr. Adolesc. Med.
PD MAY
PY 2010
VL 164
IS 5
BP 406
EP 411
PG 6
WC Pediatrics
SC Pediatrics
GA 590XG
UT WOS:000277261100001
PM 20439790
ER
PT J
AU Atladottir, HO
Thorsen, P
Schendel, DE
Ostergaard, L
Lemcke, S
Parner, ET
AF Atladottir, Hjordis Osk
Thorsen, Poul
Schendel, Diana E.
Ostergaard, Lars
Lemcke, Saane
Parner, Erik T.
TI Association of Hospitalization for Infection in Childhood With Diagnosis
of Autism Spectrum Disorders A Danish Cohort Study
SO ARCHIVES OF PEDIATRICS & ADOLESCENT MEDICINE
LA English
DT Article
ID MEDICAL DISORDERS; CHILDREN; REGISTER; PREVALENCE; EXPRESSION; DENMARK;
TRENDS; CELLS; TIME
AB Objective: To investigate the association between hospitalization for infection in the perinatal/neonatal period or childhood and the diagnosis of autism spectrum disorders (ASDs).
Design: A population-based cohort study.
Setting: Denmark.
Participants: All children born in Denmark from January 1, 1980, through December 31, 2002, comprising a total of 1 418 152 children.
Exposure: Infection requiring hospitalization.
Main Outcome Measure: The adjusted hazard ratio (HR) for ASDs among children hospitalized for infection compared with other children.
Results: A total of 7379 children were diagnosed as having ASDs. Children admitted to the hospital for any infectious disease displayed an increased rate of ASD diagnoses (HR, 1.38 [95% confidence interval, 1.31-1.45]). This association was found to be similar for infectious diseases of bacterial and viral origin. Furthermore, children admitted to the hospital for noninfectious disease also displayed an increased rate of ASD diagnoses (HR, 1.76 [95% confidence interval, 1.68-1.86]), and admissions for infection increased the rate of mental retardation (2.18 [2.06-2.31]).
Conclusions: The association between hospitalization for infection and ASDs observed in this study does not suggest causality because a general association is observed across different infection groups. Also, the association is not specific for infection or for ASDs. We discuss a number of noncausal explanatory models.
C1 [Atladottir, Hjordis Osk; Lemcke, Saane; Parner, Erik T.] Aarhus Univ, Inst Publ Hlth, Dept Epidemiol, DK-8000 Aarhus C, Denmark.
[Parner, Erik T.] Aarhus Univ, Inst Publ Hlth, Dept Biostat, DK-8000 Aarhus, Denmark.
[Schendel, Diana E.] Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA USA.
[Ostergaard, Lars] Arhus Univ Hosp, Dept Infect Dis, Res Unit Q, Skejby, Denmark.
RP Atladottir, HO (reprint author), Aarhus Univ, Inst Publ Hlth, Dept Epidemiol, Bartholin Alle 2, DK-8000 Aarhus C, Denmark.
EM hoa@soci.au.dk
RI Parner, Erik/F-5532-2010
FU Arhus University Research Foundation; Aase and Ejnar Danielsens
Foundation; Augustinus Foundation; Familien Hede Nielsens Foundation;
Lundbeck Foundation
FX This study was supported by the Arhus University Research Foundation,
the Aase and Ejnar Danielsens Foundation, the Augustinus Foundation, the
Familien Hede Nielsens Foundation, and the Lundbeck Foundation.
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NR 43
TC 33
Z9 34
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 515 N STATE ST, CHICAGO, IL 60610-0946 USA
SN 1072-4710
J9 ARCH PEDIAT ADOL MED
JI Arch. Pediatr. Adolesc. Med.
PD MAY
PY 2010
VL 164
IS 5
BP 470
EP 477
PG 8
WC Pediatrics
SC Pediatrics
GA 590XG
UT WOS:000277261100012
PM 20439799
ER
PT J
AU Sung, M
Fung, DSS
Cai, YM
Ooi, YP
AF Sung, Min
Fung, Daniel S. S.
Cai, Yiming
Ooi, Yoon Phaik
TI Pharmacological management in children and adolescents with pervasive
developmental disorder
SO AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY
LA English
DT Article
DE Asperger's syndrome; autism; autism spectrum disorder; pervasive
developmental; disorder; pharmacological management
ID PLACEBO-CONTROLLED CROSSOVER; YOUNG AUTISTIC-CHILDREN;
CONTROLLED-RELEASE MELATONIN; OPEN-LABEL TRIAL; DOUBLE-BLIND; SPECTRUM
DISORDERS; MENTAL-RETARDATION; RETROSPECTIVE ANALYSIS; REPETITIVE
BEHAVIORS; DIVALPROEX SODIUM
AB Methods: Electronic literature searches were conducted from the following sources: MEDLINE, Cochrane Library, PSYARTICLES and PsycINFO. Search terms included, but were not limited to, 'autism', 'PDD', 'autism spectrum disorder' ('ASD'), and 'pharmacological management'.
Results: A range of pharmacological agents are available for the management of various dysfunctional symptoms in PDD. Broadly speaking, these agents help in the management of repetitive stereotyped behaviours, anxiety, aggression/irritability/self-injurious behaviour, hyperactivity/inattention and in sleep.
Conclusions: There is a paucity of systemic, well-conducted trials on the use of pharmacological agents in the management of PDD, and more research in this area is warranted.
C1 [Sung, Min] Inst Mental Hlth, Dept Child & Adolescent Psychiat, Singapore, Singapore.
Child Guidance Clin, Singapore 168937, Singapore.
RP Sung, M (reprint author), Inst Mental Hlth, Dept Child & Adolescent Psychiat, Singapore, Singapore.
EM min_sung@imh.com.sg
RI Ooi, Yoon Phaik/D-3944-2015
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NR 79
TC 4
Z9 4
PU INFORMA HEALTHCARE
PI NEW YORK
PA 52 VANDERBILT AVE, NEW YORK, NY 10017 USA
SN 0004-8674
J9 AUST NZ J PSYCHIAT
JI Aust. N. Z. J. Psych.
PD MAY
PY 2010
VL 44
IS 5
BP 410
EP 428
DI 10.3109/00048670903493330
PG 19
WC Psychiatry
SC Psychiatry
GA 584OD
UT WOS:000276761100002
PM 20047454
ER
PT J
AU Bolte, S
Golan, O
Goodwin, MS
Zwaigenbaum, L
AF Bolte, Sven
Golan, Ofer
Goodwin, Matthew S.
Zwaigenbaum, Lonnie
TI What can innovative technologies do for Autism Spectrum Disorders?
SO AUTISM
LA English
DT Editorial Material
ID COMPUTER-ASSISTED-INSTRUCTION; VIRTUAL ENVIRONMENTS; CHILDREN;
ADOLESCENTS
CR Bernard-Opitz V, 2001, J AUTISM DEV DISORD, V31, P377, DOI 10.1023/A:1010660502130
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Wolfberg P. J., 2009, PLAY IMAGINATION CHI
NR 15
TC 12
Z9 12
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1362-3613
J9 AUTISM
JI Autism
PD MAY
PY 2010
VL 14
IS 3
BP 155
EP 159
DI 10.1177/1362361310365028
PG 5
WC Psychology, Developmental
SC Psychology
GA 618SV
UT WOS:000279376900001
PM 20603897
ER
PT J
AU Lacava, PG
Rankin, A
Mahlios, E
Cook, K
Simpson, RL
AF Lacava, Paul G.
Rankin, Ana
Mahlios, Emily
Cook, Katie
Simpson, Richard L.
TI A single case design evaluation of a software and tutor intervention
addressing emotion recognition and social interaction in four boys with
ASD
SO AUTISM
LA English
DT Article
DE autism spectrum disorders; computers; emotion; social interaction
ID ASPERGER-SYNDROME; COMPLEX EMOTION; AUTISM; ADULTS; CHILDREN; EMPATHY;
MIND
AB Many students with Autism Spectrum Disorders (ASD) have delays learning to recognize emotions. Social behavior is also challenging, including initiating interactions, responding to others, developing peer relationships, and so forth. In this single case design study we investigated the relationship between use of computer software ( Mind Reading: The Interactive Guide to Emotions) and emotion recognition ( ER) and social behavior change. After using Mind Reading for 7 to 10 weeks with a tutor, four boys with ASD improved ER scores and social interactions with peers. However, observed behavior changes were not strong enough to claim a causal relationship between variables. Findings, practice implications, and future research are discussed.
C1 [Lacava, Paul G.; Rankin, Ana; Mahlios, Emily; Cook, Katie; Simpson, Richard L.] Univ Kansas, Lawrence, KS 66045 USA.
RP Lacava, PG (reprint author), Rhode Isl Coll, 600 Mt Pleasant Ave,Horace Mann Hall Room 061, Providence, RI 02908 USA.
EM placava@ric.edu
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NR 27
TC 9
Z9 9
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1362-3613
J9 AUTISM
JI Autism
PD MAY
PY 2010
VL 14
IS 3
BP 161
EP 178
DI 10.1177/1362361310362085
PG 18
WC Psychology, Developmental
SC Psychology
GA 618SV
UT WOS:000279376900002
PM 20488823
ER
PT J
AU Whalen, C
Moss, D
Ilan, A
Vaupel, M
Fielding, P
MacDonald, K
Cernich, S
Symon, J
AF Whalen, Christina
Moss, Debbie
Ilan, Aaron B.
Vaupel, Manya
Fielding, Paul
MacDonald, Kevin
Cernich, Shannon
Symon, Jennifer
TI Efficacy of TeachTown: Basics computer-assisted intervention for the
Intensive Comprehensive Autism Program in Los Angeles Unified School
District
SO AUTISM
LA English
DT Article
DE academics; Applied Behavior Aanalysis; cognitive skills; Computer
Assisted Instruction; computers; generalization; language; social
skills; TeachTown; technology
ID CHILDREN; BEHAVIOR
AB Computer Assisted Instruction (CAI) has shown increased popularity recently and there are many studies showing promise for this approach for children with Autism Spectrum Disorders (ASD). However, there are no between-subject studies to date assessing the efficacy of CAI with this population. In this study, 47 preschool and K-1 students in ASD classrooms participated from Los Angeles Unified School District. TeachTown: Basics, a CAI program which also includes supplementary off-computer activities, was implemented over 3 months for approximately 20 minutes per day on the computer and 20 minutes per day in supplementary TeachTown: Basics activities. Compared to the students in the control group, the TeachTown: Basics students showed more improvement overall on language and cognitive outcome measures. In addition, students who used TeachTown: Basics demonstrated significant progress overall in the software and those students who used the program for more time demonstrated larger gains within the software and in outcome measures. Although not conclusive, these findings offer possibilities for the use of CAI for remediating many deficits for children with ASD and other special needs. In addition, CAI may offer solutions to schools and parents with insufficient funds for more expensive treatments.
C1 [Whalen, Christina; Vaupel, Manya; MacDonald, Kevin; Cernich, Shannon] Jigsaw Learning, TeachTown, Seattle, WA 98102 USA.
[Moss, Debbie] Los Angeles Unified Sch Dist, Los Angeles, CA USA.
[Symon, Jennifer] Calif State Univ Los Angeles, Los Angeles, CA 90032 USA.
RP Whalen, C (reprint author), Jigsaw Learning, TeachTown, 2815 Eastlake Ave E,Suite 300, Seattle, WA 98102 USA.
EM chris@jigsawlearning.com
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NR 32
TC 13
Z9 13
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1362-3613
J9 AUTISM
JI Autism
PD MAY
PY 2010
VL 14
IS 3
BP 179
EP 197
DI 10.1177/1362361310363282
PG 19
WC Psychology, Developmental
SC Psychology
GA 618SV
UT WOS:000279376900003
PM 20484002
ER
PT J
AU Wallace, S
Parsons, S
Westbury, A
White, K
White, K
Bailey, A
AF Wallace, Simon
Parsons, Sarah
Westbury, Alice
White, Katie
White, Kathy
Bailey, Anthony
TI Sense of presence and atypical social judgments in immersive virtual
environments Responses of adolescents with Autism Spectrum Disorders
SO AUTISM
LA English
DT Article
DE Autism Spectrum Disorder; virtual reality technology
ID DEVELOPMENTAL DISORDERS; REALITY; CHILDREN; SKILLS; INDIVIDUALS;
INSTRUCTION; TECHNOLOGY; TOOL
AB Immersive virtual environments (IVEs) are potentially powerful educational resources but their application for children with Autism Spectrum Disorder (ASD) is under researched. This study aimed to answer two research questions: (1) Do children with ASD experience IVEs in different ways to typically developing children given their cognitive, perceptual and sensory differences? and (2) Can an IVE accurately simulate ecologically valid social situations? Ten children with ASD and 14 typically developing (TD) adolescents all aged 12-16 years experienced three different IVEs. They completed self-report questionnaires on their sense of 'presence' in the IVEs and rated 'social attractiveness' of a virtual character in socially desirable and undesirable scenarios. The children with ASD reported similar levels of presence to their TD peers and no negative sensory experiences. Although TD adolescents rated the socially desirable character as more socially attractive than the undesirable character, adolescents with ASD rated the two characters as equally socially attractive. These findings suggest that children with ASD do not experience IVEs in different ways to their TD counterparts and that the IVEs are realistic enough to simulate authentic social situations. This study paints a very encouraging picture for the potential uses of IVEs in assessing and educating individuals with ASD.
C1 [Parsons, Sarah] Univ Birmingham, Sch Educ, Birmingham B15 2TT, W Midlands, England.
[Wallace, Simon; Westbury, Alice; White, Katie; White, Kathy; Bailey, Anthony] Univ Oxford, Oxford OX1 2JD, England.
RP Parsons, S (reprint author), Univ Birmingham, Sch Educ, Birmingham B15 2TT, W Midlands, England.
EM s.j.parsons@bham.ac.uk
RI Bailey, Anthony/J-2860-2014
OI Bailey, Anthony/0000-0003-4257-972X
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NR 26
TC 13
Z9 13
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1362-3613
J9 AUTISM
JI Autism
PD MAY
PY 2010
VL 14
IS 3
BP 199
EP 213
DI 10.1177/1362361310363283
PG 15
WC Psychology, Developmental
SC Psychology
GA 618SV
UT WOS:000279376900004
PM 20484000
ER
PT J
AU Van Santen, J
Prud'hommeaux, ET
Black, LM
Mitchell, M
AF Van Santen, Jan P. H.
Prud'hommeaux, Emily T.
Black, Lois M.
Mitchell, Margaret
TI Computational prosodic markers for autism
SO AUTISM
LA English
DT Article
DE autism; acoustic; computational; prosody; speech
ID HIGH-FUNCTIONING AUTISM; DIAGNOSTIC-OBSERVATION-SCHEDULE; LANGUAGE
IMPAIRMENT; SPECTRUM DISORDERS; REVISED ALGORITHMS; LINGUISTIC STRESS;
CHILDREN; SPEECH; DURATION; VALIDITY
AB We present results obtained with new instrumental methods for the acoustic analysis of prosody to evaluate prosody production by children with Autism Spectrum Disorder (ASD) and Typical Development (TD). Two tasks elicit focal stress - one in a vocal imitation paradigm, the other in a picture-description paradigm; a third task also uses a vocal imitation paradigm, and requires repeating stress patterns of two-syllable nonsense words. The instrumental methods differentiated significantly between the ASD and TD groups in all but the focal stress imitation task. The methods also showed smaller differences in the two vocal imitation tasks than in the picture-description task, as was predicted. In fact, in the nonsense word stress repetition task, the instrumental methods showed better performance for the ASD group. The methods also revealed that the acoustic features that predict auditory-perceptual judgment are not the same as those that differentiate between groups. Specifically, a key difference between the groups appears to be a difference in the balance between the various prosodic cues, such as pitch, amplitude, and duration, and not necessarily a difference in the strength or clarity with which prosodic contrasts are expressed.
C1 [Van Santen, Jan P. H.] Oregon Hlth & Sci Univ, Div Biomed Comp Sci, Beaverton, OR 97006 USA.
[Mitchell, Margaret] Univ Aberdeen, Aberdeen AB9 1FX, Scotland.
RP Van Santen, J (reprint author), Oregon Hlth & Sci Univ, Div Biomed Comp Sci, 20000 NW Walker Rd, Beaverton, OR 97006 USA.
EM vansanten@cslu.ogi.edu
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NR 56
TC 10
Z9 10
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1362-3613
J9 AUTISM
JI Autism
PD MAY
PY 2010
VL 14
IS 3
BP 215
EP 236
DI 10.1177/1362361309363281
PG 22
WC Psychology, Developmental
SC Psychology
GA 618SV
UT WOS:000279376900005
PM 20591942
ER
PT J
AU Farr, W
Yuill, N
Raffle, H
AF Farr, William
Yuill, Nicola
Raffle, Hayes
TI Social benefits of a tangible user interface for children with Autistic
Spectrum Conditions
SO AUTISM
LA English
DT Article
DE autism; computing; patterns; play; tangibles
ID DISORDERS; PLAY
AB Tangible user interfaces (TUIs) embed computer technology in graspable objects. This study assessed the potential of Topobo, a construction toy with programmable movement, to support social interaction in children with Autistic Spectrum Conditions (ASC). Groups of either typically developing (TD) children or those with ASC had group play sessions with Topobo and with LEGO (TM). We recorded the extent and sequence of different categories of play during these sessions. For both participant groups, there were more social forms of play with Topobo than with LEGO (TM). More solitary play occurred for LEGO (TM) and more parallel play occurred with Topobo. Topobo was also associated with more time in onlooker and cooperative play in TD. Finally, we observed differences in play sequences between TD and ASC children, and discuss how different play materials might produce specific patterns of play in these two groups.
C1 [Yuill, Nicola] Univ Sussex, Sch Psychol, Brighton BN1 9QH, E Sussex, England.
[Raffle, Hayes] Nokia Res, Palo Alto, CA USA.
RP Yuill, N (reprint author), Univ Sussex, Sch Psychol, Lewes Rd, Brighton BN1 9QH, E Sussex, England.
EM nicolay@sussex.ac.uk
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NR 34
TC 15
Z9 15
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1362-3613
J9 AUTISM
JI Autism
PD MAY
PY 2010
VL 14
IS 3
BP 237
EP 252
DI 10.1177/1362361310363280
PG 16
WC Psychology, Developmental
SC Psychology
GA 618SV
UT WOS:000279376900006
PM 20484323
ER
PT J
AU Hayashida, K
Anderson, B
Paparella, T
Freeman, SFN
Forness, SR
AF Hayashida, Kristen
Anderson, Bryan
Paparella, Tanya
Freeman, Stephanny F. N.
Forness, Steven R.
TI Comorbid Psychiatric Diagnoses in Preschoolers with Autism Spectrum
Disorders
SO BEHAVIORAL DISORDERS
LA English
DT Article
ID PERVASIVE DEVELOPMENTAL DISORDERS; BEHAVIORAL-DISORDERS; CHILDREN;
PREVALENCE; DEPRESSION; PDD; PSYCHOPATHOLOGY; CONSULTATION; POPULATION;
SYMPTOMS
AB Although comorbid or co-occurring psychiatric diagnoses such as attention deficit hyperactivity disorder, anxiety disorders, depression, and oppositional defiant or conduct disorders have been well studied in children or adolescents with autism spectrum disorders (ASDs), very little research is available on preschool samples. The current study involves 175 preschoolers with ASDs attending a day-treatment preschool for interdisciplinary services in a clinical psychiatric hospital. Two different diagnostic instruments were used not only to determine clinical cutoffs for the previously mentioned disorders but also to confirm ASDs diagnoses. Although most comorbid diagnoses were found at rates comparable to those found in previous studies, depression or dysthymia tended to be prevalent at much higher levels than expected. Practical implications of these findings are discussed.
C1 [Hayashida, Kristen; Anderson, Bryan; Paparella, Tanya; Freeman, Stephanny F. N.; Forness, Steven R.] Univ Calif Los Angeles, Resnick Neuropsychiat Hosp, Los Angeles, CA 90024 USA.
RP Paparella, T (reprint author), Univ Calif Los Angeles, Dept Psychiat & Behav Sci, Neuropsychiat Inst 78 222, 760 Westwood Plaza, Los Angeles, CA 90024 USA.
EM TPaparella@mednet.ucla.edu
CR Achenbach TM, 2001, MANUAL ASEBA PRESCHO
American Psychiatric Association, 2000, DIAGN STAT MAN MENT
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Luby JL, 2009, ARCH GEN PSYCHIAT, V66, P897, DOI 10.1001/archgenpsychiatry.2009.97
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Skuse DH, 2009, J AM ACAD CHILD PSY, V48, P128, DOI 10.1097/CHI.0b013e31819176b8
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WECHSLER D, 2002, WPPSI 3 WECHSLER PR
NR 45
TC 4
Z9 4
PU COUNCIL CHILDREN BEHAVIORAL DISORDERS
PI ARLINGTON
PA COUNCIL EXCEPTIONAL CHILDREN, 1110 NORTH GLEBE RD, ARLINGTON, VA
22201-5704 USA
SN 0198-7429
J9 BEHAV DISORDERS
JI Behav. Disord.
PD MAY
PY 2010
VL 35
IS 3
BP 243
EP 254
PG 12
WC Psychology, Clinical; Psychology, Educational
SC Psychology
GA 689IP
UT WOS:000284921600005
ER
PT J
AU Modi, ME
Young, LJ
AF Modi, Meera E.
Young, Larry J.
TI Drugs that Stimulate Oxytocin Release Promote Social Bonding in an
Animal Model Relevant to Autism
SO BIOLOGICAL PSYCHIATRY
LA English
DT Meeting Abstract
CT 65th Annual Convention of the Society-of-Biological-Psychiatry
CY MAY 20-22, 2010
CL New Orleans, LA
SP Soc Biol Psychiat
C1 [Modi, Meera E.; Young, Larry J.] Emory Univ, Dept Psychiat, Atlanta, GA 30322 USA.
NR 0
TC 0
Z9 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD MAY 1
PY 2010
VL 67
IS 9
SU S
MA 84
BP 26S
EP 26S
PG 1
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA 588IX
UT WOS:000277064200084
ER
PT J
AU Hall, GBC
Doyle, KAR
Goldberg, J
Szatmari, P
AF Hall, Geoffrey B. C.
Doyle, Krissy A. R.
Goldberg, Jeremy
Szatmari, Peter
TI Neuro-Functional Networks Supporting Cross-Sensory Emotion Processing in
Teens with Autism Spectrum Disorder
SO BIOLOGICAL PSYCHIATRY
LA English
DT Meeting Abstract
CT 65th Annual Convention of the Society-of-Biological-Psychiatry
CY MAY 20-22, 2010
CL New Orleans, LA
SP Soc Biol Psychiat
C1 [Hall, Geoffrey B. C.; Doyle, Krissy A. R.] McMaster Univ, Hamilton, ON, Canada.
[Goldberg, Jeremy; Szatmari, Peter] Offord Ctr Child Studies, Hamilton, ON, Canada.
NR 0
TC 0
Z9 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD MAY 1
PY 2010
VL 67
IS 9
SU S
MA 131
BP 41S
EP 41S
PG 1
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA 588IX
UT WOS:000277064200131
ER
PT J
AU Swartz, JR
Weng, SJ
Carrasco, M
Wiggins, JL
Phan, KL
Lord, C
Monk, CS
AF Swartz, Johnna R.
Weng, Shih-Jen
Carrasco, Melisa
Wiggins, Jillian Lee
Phan, K. Luan
Lord, Catherine
Monk, Christopher S.
TI The Relationship between Amygdala Activation to Emotional Faces and
Anxiety Symptoms in Adolescents with Autism Spectrum Disorders
SO BIOLOGICAL PSYCHIATRY
LA English
DT Meeting Abstract
CT 65th Annual Convention of the Society-of-Biological-Psychiatry
CY MAY 20-22, 2010
CL New Orleans, LA
SP Soc Biol Psychiat
C1 [Lord, Catherine] Univ Michigan, Autism & Commun Disorders Ctr, Ann Arbor, MI 48109 USA.
[Lord, Catherine; Monk, Christopher S.] Univ Michigan, Ctr Human Growth & Dev, Ann Arbor, MI 48109 USA.
RI Monk, Christopher/J-1805-2014
NR 0
TC 0
Z9 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD MAY 1
PY 2010
VL 67
IS 9
SU S
MA 133
BP 41S
EP 42S
PG 2
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA 588IX
UT WOS:000277064200133
ER
PT J
AU Yucel, G
Belger, A
AF Yucel, Gunes
Belger, Aysenil
TI Relationship between Novelty Change Detection and Autistic Traits in
Adolescents with Autism
SO BIOLOGICAL PSYCHIATRY
LA English
DT Meeting Abstract
CT 65th Annual Convention of the Society-of-Biological-Psychiatry
CY MAY 20-22, 2010
CL New Orleans, LA
SP Soc Biol Psychiat
C1 [Yucel, Gunes; Belger, Aysenil] Univ N Carolina, Chapel Hill, NC USA.
[Yucel, Gunes; Belger, Aysenil] Duke Univ, Med Ctr, Brain Imaging & Anal Ctr, Durham, NC USA.
NR 0
TC 0
Z9 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD MAY 1
PY 2010
VL 67
IS 9
SU S
MA 136
BP 42S
EP 43S
PG 2
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA 588IX
UT WOS:000277064200136
ER
PT J
AU Yucel, G
Parlier, M
Adolphs, R
Belger, A
Piven, J
AF Yucel, Gunes
Parlier, Morgan
Adolphs, Ralph
Belger, Aysenil
Piven, Joseph
TI Face Processing in the Broad Autism Phenotype: An fMRI Study
SO BIOLOGICAL PSYCHIATRY
LA English
DT Meeting Abstract
CT 65th Annual Convention of the Society-of-Biological-Psychiatry
CY MAY 20-22, 2010
CL New Orleans, LA
SP Soc Biol Psychiat
C1 [Yucel, Gunes; Belger, Aysenil] Duke Univ, Med Ctr, Brain Imaging & Anal Ctr, Durham, NC USA.
[Adolphs, Ralph] CALTECH, Div Human & Social Sci, Pasadena, CA 91125 USA.
[Adolphs, Ralph] CALTECH, Div Biol, Pasadena, CA 91125 USA.
[Piven, Joseph] UNC CH, Neurodev Disorders Res Ctr, Chapel Hill, NC USA.
NR 0
TC 0
Z9 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD MAY 1
PY 2010
VL 67
IS 9
SU S
MA 137
BP 43S
EP 43S
PG 1
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA 588IX
UT WOS:000277064200137
ER
PT J
AU Fatemi, SH
Reutiman, TJ
Folsom, TD
Winter, C
Sohr, R
Klein, J
Thuras, PD
AF Fatemi, Seyyed H.
Reutiman, Teri J.
Folsom, Timothy D.
Winter, Christine
Sohr, Reinhard
Klein, Julia
Thuras, Paul D.
TI mRNA and Protein for GABAA alpha 4, alpha 5, beta 1 and GABABR1 are
Reduced in Brains from Subjects with Autism
SO BIOLOGICAL PSYCHIATRY
LA English
DT Meeting Abstract
CT 65th Annual Convention of the Society-of-Biological-Psychiatry
CY MAY 20-22, 2010
CL New Orleans, LA
SP Soc Biol Psychiat
C1 [Fatemi, Seyyed H.; Reutiman, Teri J.; Folsom, Timothy D.; Thuras, Paul D.] Univ Minnesota, Minneapolis, MN USA.
[Winter, Christine; Sohr, Reinhard; Klein, Julia] Charite, D-13353 Berlin, Germany.
NR 0
TC 0
Z9 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD MAY 1
PY 2010
VL 67
IS 9
SU S
MA 755
BP 216S
EP 217S
PG 2
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA 588IX
UT WOS:000277064200685
ER
PT J
AU Guo, YQ
Tang, YL
Rice, C
Lee, LC
Wang, YF
Cubells, JF
AF Guo, Yanqing
Tang, Yilang
Rice, Catherine
Lee, Li-Ching
Wang, Yufeng
Cubells, Joseph F.
TI Validation of the Autism Spectrum Screening Scale (ASSQ), Mandarin
Chinese Version
SO BIOLOGICAL PSYCHIATRY
LA English
DT Meeting Abstract
CT 65th Annual Convention of the Society-of-Biological-Psychiatry
CY MAY 20-22, 2010
CL New Orleans, LA
SP Soc Biol Psychiat
C1 [Guo, Yanqing; Wang, Yufeng] Peking Univ, Hlth Sci Ctr, Inst Mental Hlth, Beijing 100871, Peoples R China.
[Tang, Yilang; Cubells, Joseph F.] Emory Univ, Atlanta, GA 30322 USA.
[Rice, Catherine] CDC & Prevent, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA USA.
[Lee, Li-Ching] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Baltimore, MD USA.
NR 0
TC 0
Z9 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD MAY 1
PY 2010
VL 67
IS 9
SU S
MA 762
BP 219S
EP 219S
PG 1
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA 588IX
UT WOS:000277064200692
ER
PT J
AU Sakurai, T
Ramoz, N
Barreto, M
Gazdoiu, M
Takahashi, N
Gertner, M
Dorr, N
Sosa, MAG
De Gasperi, R
Perez, G
Schmeidler, J
Mitropoulou, V
Le, HC
Lupu, M
Hof, PR
Elder, GA
Buxbaum, JD
AF Sakurai, Takeshi
Ramoz, Nicolas
Barreto, Marta
Gazdoiu, Mihaela
Takahashi, Nagahide
Gertner, Michael
Dorr, Nathan
Sosa, Miguel A. Gama
De Gasperi, Rita
Perez, Gissel
Schmeidler, James
Mitropoulou, Vivian
Le, H. Carl
Lupu, Mihaela
Hof, Patrick R.
Elder, Gregory A.
Buxbaum, Joseph D.
TI Slc25a12 Disruption Alters Myelination and Neurofilaments: A Model for a
Hypomyelination Syndrome and Childhood Neurodevelopmental Disorders
SO BIOLOGICAL PSYCHIATRY
LA English
DT Article
DE Malate/aspartate shuttle; mitochondria; N-acetylaspartate (NAA);
neuron-oligodendrocyte interactions; pyruvate
ID MAGNETIC-RESONANCE-SPECTROSCOPY; AUTISM SPECTRUM DISORDERS;
ASPARTATE-GLUTAMATE; BRAIN-METABOLITES; WHITE-MATTER; CARRIER; GENE;
ASSOCIATION; CHILDREN; MITOCHONDRIA
AB Background: SLC25A12, a susceptibility gene for autism spectrum disorders that is mutated in a neurodevelopmental syndrome, encodes a mitochondrial aspartate-glutamate carrier (aspartate-glutamate carrier isoform 1 [AGC1]). AGC1 is an important component of the malate/aspartate shuttle, a crucial system supporting oxidative phosphorylation and adenosine triphosphate production.
Methods: We characterized mice with a disruption of the Slc25a12 gene, followed by confirmatory in vitro studies.
Results: Slc25a12-knockout mice, which showed no AGC1 by immunoblotting, were born normally but displayed delayed development and died around 3 weeks after birth. In postnatal day 13 to 14 knockout brains, the brains were smaller with no obvious alteration in gross structure. However, we found a reduction in myelin basic protein (MBP)-positive fibers, consistent with a previous report. Furthermore, the neocortex of knockout mice contained abnormal neurofilamentous accumulations in neurons, suggesting defective axonal transport and/or neurodegeneration. Slice cultures prepared from knockout mice also showed a myelination defect, and reduction of Slc25a12 in rat primary oligodendrocytes led to a cell-autonomous reduction in MBP expression. Myelin deficits in slice cultures from knockout mice could be reversed by administration of pyruvate, indicating that reduction in AGC1 activity leads to reduced production of aspartate/N-acetylaspartate and/or alterations in the dihydronicotinamide adenine dinucleotide/nicotinamide adenine dinucleotide(+) ratio, resulting in myelin defects.
Conclusions: Our data implicate AGC1 activity in myelination and in neuronal structure and indicate that while loss of AGC1 leads to hypomyelination and neuronal changes, subtle alterations in AGC1 expression could affect brain development, contributing to increased autism susceptibility.
C1 [Sakurai, Takeshi; Ramoz, Nicolas; Barreto, Marta; Gazdoiu, Mihaela; Takahashi, Nagahide; Gertner, Michael; Dorr, Nathan; Sosa, Miguel A. Gama; De Gasperi, Rita; Perez, Gissel; Schmeidler, James; Mitropoulou, Vivian; Elder, Gregory A.; Buxbaum, Joseph D.] Mt Sinai Sch Med, Dept Psychiat, New York, NY 10029 USA.
[Sakurai, Takeshi; Ramoz, Nicolas; Buxbaum, Joseph D.] Mt Sinai Sch Med, Seaver Autism Ctr Res & Treatment, New York, NY 10029 USA.
[Sakurai, Takeshi] Mt Sinai Sch Med, Dept Pharmacol & Syst Therapeut, New York, NY 10029 USA.
[Sakurai, Takeshi] Mt Sinai Sch Med, Black Family Stem Cell Inst, New York, NY 10029 USA.
[Hof, Patrick R.; Buxbaum, Joseph D.] Mt Sinai Sch Med, Dept Neurosci, New York, NY 10029 USA.
[Buxbaum, Joseph D.] Mt Sinai Sch Med, Dept Genet & Genom Sci, New York, NY 10029 USA.
[Le, H. Carl; Lupu, Mihaela] Mem Sloan Kettering Canc Ctr, Dept Med Phys, New York, NY 10021 USA.
[Elder, Gregory A.] James J Peters Dept Vet Affairs Med Ctr, Neurol Serv, Bronx, NY USA.
RP Buxbaum, JD (reprint author), Mt Sinai Sch Med, Dept Psychiat, 1 Gustave L Levy Pl,Box 1668, New York, NY 10029 USA.
EM joseph.buxbaum@mssm.edu
RI Le, Hongbiao /H-4735-2011; Barreto, Marta/F-5591-2012
OI Barreto, Marta/0000-0001-6464-548X
FU New York State Spinal Cord Injury [C020935]; Stanley Medical Research
Institute [06R-1427]; Seaver Foundation; National Institute of Mental
Health [MH066673]; National Institutes of Health (NIH) [R24CA83084,
P30CA08748]
FX TS is a Seaver Fellow and supported in part by New York State Spinal
Cord Injury contract (C020935) and Stanley Medical Research Institute
research grant (06R-1427). This research was supported by the Seaver
Foundation (TS and JDB) and the National Institute of Mental Health
(MH066673, JDB). Technical services at the Memorial Sloan-Kettering
Cancer Center Small-Animal Imaging Core Facility were supported in part
by National Institutes of Health (NIH) Small-Animal Imaging Research
Program Grant R24CA83084 and NIH Center Grant P30CA08748.
CR Abrahams BS, 2008, NAT REV GENET, V9, P341, DOI 10.1038/nrg2346
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NR 31
TC 16
Z9 18
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD MAY 1
PY 2010
VL 67
IS 9
BP 887
EP 894
DI 10.1016/j.biopsych.2009.08.042
PG 8
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA 588IW
UT WOS:000277064100013
PM 20015484
ER
PT J
AU Garbern, JY
Neumann, M
Trojanowski, JQ
Lee, VMY
Feldman, G
Norris, JW
Friez, MJ
Schwartz, CE
Stevenson, R
Sima, AAF
AF Garbern, James Y.
Neumann, Manuela
Trojanowski, John Q.
Lee, Virginia M. -Y.
Feldman, Gerald
Norris, Joy W.
Friez, Michael J.
Schwartz, Charles E.
Stevenson, Roger
Sima, Anders A. F.
TI A mutation affecting the sodium/proton exchanger, SLC9A6, causes mental
retardation with tau deposition
SO BRAIN
LA English
DT Article
DE mental retardation; corticobasal degeneration; tau expression; SLC9A6;
autism
ID FRONTOTEMPORAL LOBAR DEGENERATION; PROGRESSIVE SUPRANUCLEAR PALSY;
AMYOTROPHIC-LATERAL-SCLEROSIS; PARKINSONISM-DEMENTIA COMPLEX; PAIRED
HELICAL FILAMENTS; CORTICOBASAL INCLUSION-BODIES; SWOLLEN ACHROMATIC
NEURONS; ALZHEIMERS-DISEASE; WHITE-MATTER; PICKS-DISEASE
AB We have studied a family with severe mental retardation characterized by the virtual absence of speech, autism spectrum disorder, epilepsy, late-onset ataxia, weakness and dystonia. Post-mortem examination of two males revealed widespread neuronal loss, with the most striking finding being neuronal and glial tau deposition in a pattern reminiscent of corticobasal degeneration. Electron microscopic examination of isolated tau filaments demonstrated paired helical filaments and ribbon-like structures. Biochemical studies of tau demonstrated a preponderance of 4R tau isoforms. The phenotype was linked to Xq26.3, and further analysis identified an in-frame 9 base pair deletion in the solute carrier family 9, isoform A6 (SLC9A6 gene), which encodes sodium/hydrogen exchanger-6 localized to endosomal vesicles. Sodium/hydrogen exchanger-6 is thought to participate in the targeting of intracellular vesicles and may be involved in recycling synaptic vesicles. The striking tau deposition in our subjects reveals a probable interaction between sodium/proton exchangers and cytoskeletal elements involved in vesicular transport, and raises the possibility that abnormalities of vesicular targeting may play an important role in more common disorders such as Alzheimer's disease and autism spectrum disorders.
C1 [Garbern, James Y.; Sima, Anders A. F.] Wayne State Univ, Sch Med, Dept Neurol, Detroit, MI 48201 USA.
[Garbern, James Y.; Feldman, Gerald] Wayne State Univ, Sch Med, Ctr Mol Med & Genet, Detroit, MI 48201 USA.
[Neumann, Manuela] Univ Zurich Hosp, Inst Neuropathol, CH-8091 Zurich, Switzerland.
[Neumann, Manuela; Trojanowski, John Q.; Lee, Virginia M. -Y.] Univ Penn, Sch Med, Dept Pathol & Lab Med, Ctr Neurodegenerat Dis Res, Philadelphia, PA 19104 USA.
[Neumann, Manuela; Trojanowski, John Q.; Lee, Virginia M. -Y.] Univ Penn, Sch Med, Inst Aging, Philadelphia, PA 19104 USA.
[Feldman, Gerald; Sima, Anders A. F.] Wayne State Univ, Sch Med, Dept Pathol, Detroit, MI 48201 USA.
[Norris, Joy W.; Friez, Michael J.; Schwartz, Charles E.; Stevenson, Roger] Greenwood Genet Ctr, Greenwood, SC 29646 USA.
RP Garbern, JY (reprint author), 421 E Canfield,Room 3217, Detroit, MI 48201 USA.
EM jgarbern@med.wayne.edu
RI Neumann, Manuela/F-6558-2011
FU National Institutes of Health [AG-09215, AG-10124, AG-17586]
FX National Institutes of Health (AG-09215, AG-10124, AG-17586).
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NR 84
TC 40
Z9 41
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0006-8950
J9 BRAIN
JI Brain
PD MAY
PY 2010
VL 133
BP 1391
EP 1402
DI 10.1093/brain/awq071
PN 5
PG 12
WC Clinical Neurology; Neurosciences
SC Neurosciences & Neurology
GA 590KV
UT WOS:000277225700018
PM 20395263
ER
PT J
AU Bird, G
Silani, G
Brindley, R
White, S
Frith, U
Singer, T
AF Bird, Geoffrey
Silani, Giorgia
Brindley, Rachel
White, Sarah
Frith, Uta
Singer, Tania
TI Empathic brain responses in insula are modulated by levels of
alexithymia but not autism
SO BRAIN
LA English
DT Article
DE empathy; autism; alexithymia; interoception; anterior insula;
mentalizing; theory of mind
ID HIGH-FUNCTIONING AUTISM; ASPERGER-SYNDROME; SPECTRUM DISORDER; NEURAL
MECHANISMS; PHYSIOLOGICAL CONDITION; SOCIAL NEUROSCIENCE; PROSOCIAL
BEHAVIOR; NORMAL ADULTS; I FEEL; PAIN
AB Difficulties in social cognition are well recognized in individuals with autism spectrum conditions (henceforth 'autism'). Here we focus on one crucial aspect of social cognition: the ability to empathize with the feelings of another. In contrast to theory of mind, a capacity that has often been observed to be impaired in individuals with autism, much less is known about the capacity of individuals with autism for affect sharing. Based on previous data suggesting that empathy deficits in autism are a function of interoceptive deficits related to alexithymia, we aimed to investigate empathic brain responses in autistic and control participants with high and low degrees of alexithymia. Using functional magnetic resonance imaging, we measured empathic brain responses with an 'empathy for pain' paradigm assessing empathic brain responses in a real-life social setting that does not rely on attention to, or recognition of, facial affect cues. Confirming previous findings, empathic brain responses to the suffering of others were associated with increased activation in left anterior insula and the strength of this signal was predictive of the degree of alexithymia in both autistic and control groups but did not vary as a function of group. Importantly, there was no difference in the degree of empathy between autistic and control groups after accounting for alexithymia. These findings suggest that empathy deficits observed in autism may be due to the large comorbidity between alexithymic traits and autism, rather than representing a necessary feature of the social impairments in autism.
C1 [Silani, Giorgia; Singer, Tania] Univ Zurich, Inst Empir Res Econ, Lab Social & Neural Syst Res, CH-8006 Zurich, Switzerland.
[Bird, Geoffrey] Univ London Birkbeck Coll, Dept Psychol Sci, London WC1E 7HX, England.
[Bird, Geoffrey; Brindley, Rachel; White, Sarah; Frith, Uta] UCL, Inst Cognit Neurosci, London WC1N 3AR, England.
RP Silani, G (reprint author), Univ Zurich, Inst Empir Res Econ, Lab Social & Neural Syst Res, Blumlisalpstr 10, CH-8006 Zurich, Switzerland.
EM silani@iew.uzh.ch
RI White, Sarah/C-4084-2008
OI White, Sarah/0000-0001-6946-9155
FU National Centre of Competence in Research (NCCR) for the Affective
Sciences, Geneva; University of Zurich [(FP7/2007-2013)/ERC, 205557];
Medical Research Council UK [G9617036]; Wellcome Trust
FX The National Centre of Competence in Research (NCCR) for the Affective
Sciences, Geneva, the University of Zurich (Research Priority Program on
the Foundations of Human Social Behaviour), and the European Research
Council under the European Community's Seventh Framework Programme
(FP7/2007-2013)/ERC Grant agreement no 205557 EMPATHICBRAIN
(to T. S.). In addition, it was funded by a Medical Research Council UK
(Grant No. G9617036) (to U. F.), and by the Wellcome Trust.
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NR 94
TC 115
Z9 117
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0006-8950
J9 BRAIN
JI Brain
PD MAY
PY 2010
VL 133
BP 1515
EP 1525
DI 10.1093/brain/awq060
PN 5
PG 11
WC Clinical Neurology; Neurosciences
SC Neurosciences & Neurology
GA 590KV
UT WOS:000277225700029
PM 20371509
ER
PT J
AU Sugie, Y
Sugie, H
Fukuda, T
Osawa, J
AF Sugie, Yoko
Sugie, Hideo
Fukuda, Tokiko
Osawa, Junko
TI Study of HOXD genes in autism particularly regarding the ratio of second
to fourth digit length
SO BRAIN & DEVELOPMENT
LA English
DT Article
DE Autism; HOXD; 2D/4D; Endophenotype; Genetic polymorphism
ID SUSCEPTIBILITY GENE; CHROMOSOME 7Q; ASSOCIATION; LINKAGE; EXPRESSION;
SCREEN; 2D/4D; 2D-4D
AB Multiple genes are involved in the pathogenesis of autism. To study the causative gene, the relationship between autism endophenotypes and their closely related genes has been analyzed. There is a subgroup of autism spectrum disorder (ASD) in which the ratio of second digit length to fourth digit length (2D/4D) is low (short digit group, SDG). We studied the relationship between ASD and HOXD genes, which are located in the candidate locus for ASD and are associated with digit morphogenesis, with a particular focus on SDG. We analyzed 25 SNPs of HOXD11, HOXD12, and HOXD13 in the subject of 98 ASD, 89 healthy controls, and 16 non-autistic patients (non-ASD). There was no significant difference in the genotype frequencies between the ASD and the healthy controls. However, the G-112T heterozyeote in the promoter region of HOXD11 was observed in only four patients with ASD and in none of the healthy controls or non-ASD subjects. Moreover, this HOXD11 G-112T was observed in three of 11 SDG with ASD but in none of the 15 non-SDG patients with ASD. There were eight SDG patients among the non-ASD ones, but this polymorphism was observed in none of them. Considering the above results, it is expected that candidate genes will be further identified, using HOXD11 G-112T polymorphism as a marker, by analyzing genes located near 2q in a larger number of ASD subjects with clinical signs of SDG. (c) 2009 Elsevier B.V. All rights reserved.
C1 [Sugie, Yoko] Hamamatsu Univ Sch Med, Dept Pediat, Higashi Ku, Hamamatsu, Shizuoka 4313192, Japan.
RP Sugie, Y (reprint author), Hamamatsu Univ Sch Med, Dept Pediat, Higashi Ku, 1-20-1 Handayama, Hamamatsu, Shizuoka 4313192, Japan.
EM y-sugie@umin.ac.jp; sugie@jichi.ac.jp; toki-fukuda@jichi.ac.jp;
yusosawa@nifty.com
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American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th
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NR 21
TC 6
Z9 7
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0387-7604
J9 BRAIN DEV-JPN
JI Brain Dev.
PD MAY
PY 2010
VL 32
IS 5
BP 356
EP 361
DI 10.1016/j.braindev.2009.05.005
PG 6
WC Clinical Neurology
SC Neurosciences & Neurology
GA 587SA
UT WOS:000277011600002
PM 19540081
ER
PT J
AU Gardener, H
Buka, SL
AF Gardener, Hannah
Buka, Stephen L.
TI Fetal androgens and autism Reply
SO BRITISH JOURNAL OF PSYCHIATRY
LA English
DT Letter
C1 [Gardener, Hannah] Univ Miami, Miller Sch Med, Dept Neurol, Miami, FL 33136 USA.
[Buka, Stephen L.] Brown Univ, Dept Community Hlth, Providence, RI 02912 USA.
RP Gardener, H (reprint author), Univ Miami, Miller Sch Med, Dept Neurol, Miami, FL 33136 USA.
EM hgardener@med.miami.edu
RI Buka, Stephen/H-7335-2014
OI Buka, Stephen/0000-0002-8578-9308
NR 0
TC 0
Z9 0
PU ROYAL COLLEGE OF PSYCHIATRISTS
PI LONDON
PA BRITISH JOURNAL OF PSYCHIATRY 17 BELGRAVE SQUARE, LONDON SW1X 8PG,
ENGLAND
SN 0007-1250
J9 BRIT J PSYCHIAT
JI Br. J. Psychiatry
PD MAY
PY 2010
VL 196
IS 5
BP 416
EP 417
DI 10.1192/bjp.196.5.416a
PG 2
WC Psychiatry
SC Psychiatry
GA 593AA
UT WOS:000277422200020
ER
PT J
AU Voracek, M
AF Voracek, Martin
TI Fetal androgens and autism
SO BRITISH JOURNAL OF PSYCHIATRY
LA English
DT Letter
ID DIGIT RATIO 2D4D
C1 Univ Vienna, Sch Psychol, Dept Basic Psychol Res, A-1010 Vienna, Austria.
RP Voracek, M (reprint author), Univ Vienna, Sch Psychol, Dept Basic Psychol Res, Liebiggasse 5,Rm 03-46, A-1010 Vienna, Austria.
EM martin.voracek@univie.ac.at
CR Baron-Cohen S, 2005, SCIENCE, V310, P819, DOI 10.1126/science.1115455
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NR 6
TC 3
Z9 3
PU ROYAL COLLEGE OF PSYCHIATRISTS
PI LONDON
PA BRITISH JOURNAL OF PSYCHIATRY 17 BELGRAVE SQUARE, LONDON SW1X 8PG,
ENGLAND
SN 0007-1250
J9 BRIT J PSYCHIAT
JI Br. J. Psychiatry
PD MAY
PY 2010
VL 196
IS 5
BP 416
EP 416
DI 10.1192/bjp.196.5.416
PG 1
WC Psychiatry
SC Psychiatry
GA 593AA
UT WOS:000277422200019
PM 20435973
ER
PT J
AU Russell, G
Kelly, S
Golding, J
AF Russell, G.
Kelly, S.
Golding, J.
TI A qualitative analysis of lay beliefs about the aetiology and prevalence
of autistic spectrum disorders
SO CHILD CARE HEALTH AND DEVELOPMENT
LA English
DT Article
DE autism; autistic spectrum disorder; grounded theory; incidence; lay
beliefs; lay understanding
ID TIME
AB Introduction
There has been a dramatic increase in the prevalence of autistic spectrum disorders (ASD) in the last 20 years. The reasons for this are disputed. The consensus among epidemiologists and other experts is that greater case load is due to changes in diagnostic practice rather than reflecting changing aetiological factors leading to a true increase in incidence. We set out to examine lay views concerning the aetiology and prevalence of ASD and whether they conflict with or support this consensus position.
Methods
Over 100 unsolicited communications (letters e mails and several telephone calls) were received by a UK epidemiological study of ASD. We carried out a qualitative analysis of all correspondence in order to examine spontaneously expressed lay beliefs about the prevalence and aetiology of ASD.
Results
The majority of correspondents suggested theories about environmental causes of ASD. This study demonstrates the strength of lay belief that the true incidence of autism is rising, and this is due to risks from modern technologies and changing lifestyles.
Conclusion
This study based on unsolicited data highlights the contrast between lay explanations of increasing prevalence and the consensus opinion of medical experts. It also demonstrates how many people in direct contact with ASD have important information to share.
C1 [Russell, G.; Kelly, S.] Univ Exeter, ESRC, Ctr Genom Soc, Exeter EX4 4PJ, Devon, England.
[Golding, J.] Univ Bristol, Dept Community Based Med, Bristol, Avon, England.
RP Russell, G (reprint author), Univ Exeter, ESRC, Ctr Genom Soc, Byrne House,St Germans Rd, Exeter EX4 4PJ, Devon, England.
EM g.russell@ex.ac.uk
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Beck U., 1992, RISK SOC NEW MODERNI
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CALNAN M., 1987, HLTH ILLNESS LAY PER
Evans R, 2007, RETHINKING EXPERTISE
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NR 17
TC 4
Z9 4
PU WILEY-BLACKWELL PUBLISHING, INC
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0305-1862
J9 CHILD CARE HLTH DEV
JI Child Care Health Dev.
PD MAY
PY 2010
VL 36
IS 3
BP 431
EP 436
DI 10.1111/j.1365-2214.2009.00994.x
PG 6
WC Psychology, Developmental; Pediatrics
SC Psychology; Pediatrics
GA 580ZI
UT WOS:000276489300020
PM 19735265
ER
PT J
AU Mouridsen, SE
Rich, B
Isager, T
AF Mouridsen, S. E.
Rich, B.
Isager, T.
TI A longitudinal study of gastrointestinal diseases in individuals
diagnosed with infantile autism as children
SO CHILD CARE HEALTH AND DEVELOPMENT
LA English
DT Article
DE gastrointestinal diseases; infantile autism; longitudinal study
ID PERVASIVE DEVELOPMENTAL DISORDERS; SPECTRUM DISORDERS; CLINICAL
DISORDERS; ASPERGER-SYNDROME; FOLLOW-UP; SYMPTOMS; PREVALENCE;
PSYCHOSIS; REGISTER; VALIDITY
AB Background
A number of studies have indicated a link between gastrointestinal (GI) diseases and autism spectrum disorders.
Method
The objective of this study was to compare the prevalence and types of GI diseases in a clinical sample of 118 individuals diagnosed as children with infantile autism (IA) with GI diseases in 336 matched controls from the general population, based on data from the nationwide Danish National Hospital Register (DNHR). The average observation time was 30.3 years (SD 0.4) (range 27-30 years), and mean age at the end of the observation period was 42.7 years (SD 7.7) (range between 27 and 57 years of age).
Results
Of the 118 individuals with IA, 97 (82.2%) had been in contact with a medical hospital (inpatient hospitalization or outpatient visits) during the observation period, compared with 312/336 (92.9%) in the control group (P = 0.001). A similar proportion of members from the case and comparison group had a diagnosis of any GI disease in the DNHR: 30.5% against 30.7%, but the nature of their diseases may be somewhat different. Only diseases of oral cavity were significantly associated with IA: 20.3% against 1.2%, P < 0.0001. Otherwise, specific GI diseases occurred with low frequency in both groups.
Conclusion
Overall, no evidence was found that patients with IA were more likely than control persons without IA to have defined GI diseases during the 30.3-year observation period.
C1 [Mouridsen, S. E.] Bispebjerg Hosp, Dept Child & Adolescent Psychiat, Copenhagen, Denmark.
[Rich, B.] Naestved Hosp, Child & Adolescent Psychiat Ctr, Naestved, Denmark.
[Isager, T.] Glostrup Univ Hosp, Ctr Child & Adolescent Psychiat, Copenhagen, Denmark.
RP Mouridsen, SE (reprint author), Bispebjerg Hosp, Dept Child & Adolescent Psychiat, Copenhagen, Denmark.
EM sem01@bbh.hosp.dk
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World Health Organization (WHO), 1971, INT CLASS DIS MAN IN
World Health Organization (WHO), 1978, INT CLASS DIS MENT D
NR 36
TC 12
Z9 12
PU WILEY-BLACKWELL PUBLISHING, INC
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0305-1862
J9 CHILD CARE HLTH DEV
JI Child Care Health Dev.
PD MAY
PY 2010
VL 36
IS 3
BP 437
EP 443
DI 10.1111/j.1365-2214.2009.01021.x
PG 7
WC Psychology, Developmental; Pediatrics
SC Psychology; Pediatrics
GA 580ZI
UT WOS:000276489300021
PM 19886906
ER
PT J
AU Brownell, CA
Nichols, SR
Svetlova, M
Zerwas, S
Ramani, G
AF Brownell, Celia A.
Nichols, Sara R.
Svetlova, Margarita
Zerwas, Stephanie
Ramani, Geetha
TI The Head Bone's Connected to the Neck Bone: When Do Toddlers Represent
Their Own Body Topography?
SO CHILD DEVELOPMENT
LA English
DT Article
ID VISUAL SELF-RECOGNITION; NEURAL BASIS; 2ND YEAR; IMITATION PERFORMANCE;
PART IDENTIFICATION; YOUNG-CHILDREN; INFANCY; AWARENESS; MULTIPLE;
AUTISM
AB Developments in very young children's topographic representations of their own bodies were examined. Sixty-one 20- and 30-month-old children were administered tasks that indexed the ability to locate specific body parts on oneself and knowledge of how one's body parts are spatially organized, as well as body-size knowledge and self-awareness. Age differences in performance emerged for every task. Body-part localization and body spatial configuration knowledge were associated; however, body topography knowledge was not associated with body-size knowledge. Both were related to traditional measures of self-awareness, mediated by their common associations with age. It is concluded that children possess an explicit, if rudimentary, topographic representation of their own body's shape, structure, and size by 30 months of age.
C1 [Brownell, Celia A.] Univ Pittsburgh, Dept Psychol, Pittsburgh, PA 15260 USA.
[Zerwas, Stephanie] Univ N Carolina Chapel Hill, Chapel Hill, NC USA.
[Ramani, Geetha] Univ Maryland, College Pk, MD 20742 USA.
RP Brownell, CA (reprint author), Univ Pittsburgh, Dept Psychol, Pittsburgh, PA 15260 USA.
EM brownell@pitt.edu
RI Ramani, Geetha/E-6317-2013
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NR 73
TC 11
Z9 11
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0009-3920
J9 CHILD DEV
JI Child Dev.
PD MAY-JUN
PY 2010
VL 81
IS 3
BP 797
EP 810
PG 14
WC Psychology, Educational; Psychology, Developmental
SC Psychology
GA 596NF
UT WOS:000277691200009
PM 20573105
ER
PT J
AU Filippova, E
Astington, JW
AF Filippova, Eva
Astington, Janet Wilde
TI Children's Understanding of Social-Cognitive and Social-Communicative
Aspects of Discourse Irony
SO CHILD DEVELOPMENT
LA English
DT Article
ID VERBAL IRONY; PRETENSE THEORY; MIND; PERCEPTIONS; UTTERANCES; ABILITY;
AUTISM
AB To bridge the social-reasoning focus of developmental research on irony understanding and the pragmatic focus of research with adult populations, this cross-sectional study examines 5-, 7-, and 9-year-olds' (n = 72) developing understanding of both social-cognitive and social-communicative aspects of discourse irony, when compared with adults (n = 24). Although 5-year-olds lag behind the other age groups in their reasoning about the speaker's meaning, belief, intention, and motivation, adults are consistently superior to children of all ages on these social-cognitive measures. In contrast, limited age-related differences were found in participants' judgment of the social-communicative function of irony (how nice, mean, and funny irony is). The findings help to reconcile previous discrepant claims as to the age when children come to understand irony.
C1 [Filippova, Eva; Astington, Janet Wilde] Univ Toronto, Toronto, ON M5S 1A1, Canada.
RP Filippova, E (reprint author), Charles Univ Prague, Inst Phonet, Fac Arts, Nam J Palacha 2, Prague 11638 1, Czech Republic.
EM eva.filippova@ff.cuni.cz
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NR 29
TC 12
Z9 12
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0009-3920
J9 CHILD DEV
JI Child Dev.
PD MAY-JUN
PY 2010
VL 81
IS 3
BP 913
EP 928
PG 16
WC Psychology, Educational; Psychology, Developmental
SC Psychology
GA 596NF
UT WOS:000277691200017
PM 20573113
ER
PT J
AU Deutsch, SI
Urbano, MR
Neumann, SA
Burket, JA
Katz, E
AF Deutsch, Stephen I.
Urbano, Maria R.
Neumann, Serina A.
Burket, Jessica A.
Katz, Elionora
TI Cholinergic Abnormalities in Autism: Is There a Rationale for Selective
Nicotinic Agonist Interventions?
SO CLINICAL NEUROPHARMACOLOGY
LA English
DT Review
DE autism; acetylcholine; nicotinic acetylcholine receptors; clinical
trials
ID MAGNETIC-RESONANCE SPECTROSCOPY; ACETYLCHOLINE-RECEPTORS;
YOUNG-CHILDREN; THERAPEUTIC IMPLICATIONS; SPECTRUM DISORDERS; BRAIN;
SCHIZOPHRENIA; ACTIVATION; DONEPEZIL; NEURONS
AB The core dysfunctions of autism spectrum disorders, which include autistic disorder, Asperger disorder, and pervasive developmental disorder not otherwise specified, include deficits in socialization and communication and a need for the preservation of "sameness;" intellectual impairment and epilepsy are common comorbidities. Data suggest that pathological involvement of cholinergic nuclei and altered expression of acetylcholine receptors, particularly nicotinic acetylcholine receptors, occur in brain of persons with autistic disorder. However, many of these studies involved postmortem tissue from small samples of primarily adult persons. Thus, the findings may reflect compensatory changes and may relate more closely to intellectual impairment and the confounding effects of seizures and medications, as opposed to the core dysfunctions of autism. Nonetheless, because of the roles played by acetylcholine receptors in general, and nicotinic acetylcholine receptors in particular, in normal processes of attention, cognition, and memory, selective cholinergic interventions should be explored for possible therapeutic effects. Additionally, there are electrophysiological data that complement the clinical observations of frequent comorbid seizure disorders in these patients, suggesting a disturbance in the balance of excitatory and inhibitory tone in the brains of persons with autistic disorders. Conceivably, because the alpha 7 nicotinic acetylcholine receptor is located on the surface of gamma-aminobutyric acid inhibitory neurons, selective stimulation of this receptor would promote gamma-aminobutyric acid's release and restore diminished inhibitory tone. The development of agonists and partial agonists for nicotinic acetylcholine receptors and positive allosteric modulators that enhance the efficiency of coupling between the binding of agonist and channel opening should facilitate consideration of clinical trials.
C1 [Deutsch, Stephen I.; Urbano, Maria R.; Neumann, Serina A.; Burket, Jessica A.; Katz, Elionora] Eastern Virginia Med Sch, Dept Psychiat & Behav Sci, Norfolk, VA 23507 USA.
RP Deutsch, SI (reprint author), Eastern Virginia Med Sch, Dept Psychiat & Behav Sci, 825 Fairfax Ave,Suite 710, Norfolk, VA 23507 USA.
EM deutscsi@evms.edu
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NR 37
TC 24
Z9 25
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0362-5664
J9 CLIN NEUROPHARMACOL
JI Clin. Neuropharmacol.
PD MAY-JUN
PY 2010
VL 33
IS 3
BP 114
EP 120
DI 10.1097/WNF.0b013e3181d6f7ad
PG 7
WC Clinical Neurology; Pharmacology & Pharmacy
SC Neurosciences & Neurology; Pharmacology & Pharmacy
GA 606ZH
UT WOS:000278467400002
PM 20190638
ER
PT J
AU Beidas, RS
Benjamin, CL
Puleo, CM
Edmunds, JM
Kendall, PC
AF Beidas, Rinad S.
Benjamin, Courtney L.
Puleo, Connor M.
Edmunds, Julie M.
Kendall, Philip C.
TI Flexible Applications of the Coping Cat Program for Anxious Youth
SO COGNITIVE AND BEHAVIORAL PRACTICE
LA English
DT Article
ID COGNITIVE-BEHAVIORAL THERAPY; RANDOMIZED CLINICAL-TRIAL; CHILDHOOD
SOCIAL PHOBIA; AUTISM SPECTRUM DISORDERS; ANXIETY DISORDERS; FOLLOW-UP;
CHILDREN; ADOLESCENTS; COMORBIDITY; DEPRESSION
AB The current article offers suggestions for ways to adapt empirically supported treatments (ESTs). A specific manualized EST (Coping Cat; Kendall & Hedtke, 2006a) is used to illustrate the concept of "flexibility within fidelity" (Kendall & Beidas, 2007; Kendall, Gosch, Furr, & Sood, 2008). Flexibility within fidelity stresses the importance of using ESTs while considering and taking into account individual client presentations. In this discussion, recommendations are offered for the use of the Coping Cat with younger youth, adolescents, and youth with secondary comorbidities (i.e., social skills deficits, inattentive symptoms, and depressive symptoms).
C1 [Beidas, Rinad S.] Temple Univ, Dept Psychol, Philadelphia, PA 19122 USA.
RP Beidas, RS (reprint author), Temple Univ, Dept Psychol, 1701 N 13th St,Weiss Hall, Philadelphia, PA 19122 USA.
EM rbeidas@temple.edu
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NR 56
TC 10
Z9 10
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1077-7229
J9 COGN BEHAV PRACT
JI Cogn. Behav. Pract.
PD MAY
PY 2010
VL 17
IS 2
BP 142
EP 153
PG 12
WC Psychology, Clinical
SC Psychology
GA 587JI
UT WOS:000276987000003
ER
PT J
AU Cheng, YF
Ye, J
AF Cheng, Yufang
Ye, Jun
TI Exploring the social competence of students with autism spectrum
conditions in a collaborative virtual learning environment - The pilot
study
SO COMPUTERS & EDUCATION
LA English
DT Article
DE Collaborative virtual learning environment; 3D Expressive avatar; Social
competence; Autism spectrum conditions
ID ASPERGER-SYNDROME; CHILDREN; ADOLESCENTS; DISORDERS; BELIEF
AB Social reciprocity deficits are a core feature of the autism spectrum conditions (ASCs). Many individual with ASCs have difficulty with social interaction due to a frequent lack of social competence. This study focuses on using a virtual learning environment to help the deficiencies of social competence for people with ASCs, and to increase their social interaction. Specifically, it primitively explores social competence in collaborative virtual learning environment (CVLE) systems, and behavioral performance in social and cognitive interactions. Thus, this CVLE-social interaction system involves a 3D expressive avatar, an animated social situation, and verbal as well as text-communication. A preliminary empirical study involved CVLE-social interaction systems. Three participants who had been diagnosed with ASCs were conducted using a multiple baseline research for evidence of improved social competence through usage of the system. The experimental study consisted of 17 days; and the results showed that using the CVLE-social interaction system had significant positive effects on participants' performance, both within the CVLE-social interaction system and in terms of reciprocal social interaction learning. (C) 2009 Elsevier Ltd. All rights reserved.
C1 [Cheng, Yufang; Ye, Jun] Natl Changhua Univ Educ, Grad Inst E Learning, Changhua, Taiwan.
RP Cheng, YF (reprint author), Natl Changhua Univ Educ, Grad Inst E Learning, 500 Jin De Campus,1 Jin De Rd, Changhua, Taiwan.
EM yfcheng@cc.ncue.edu.tw
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NR 35
TC 21
Z9 21
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0360-1315
J9 COMPUT EDUC
JI Comput. Educ.
PD MAY
PY 2010
VL 54
IS 4
BP 1068
EP 1077
DI 10.1016/j.compedu.2009.10.011
PG 10
WC Computer Science, Interdisciplinary Applications; Education &
Educational Research
SC Computer Science; Education & Educational Research
GA 575ZY
UT WOS:000276114300023
ER
PT J
AU Moalic, JM
Le Strat, Y
Lepagnol-Bestel, AM
Ramoz, N
Loe-Mie, Y
Maussion, G
Gorwood, P
Simonneau, M
AF Moalic, J. -M.
Le Strat, Y.
Lepagnol-Bestel, A. -M.
Ramoz, N.
Loe-Mie, Y.
Maussion, G.
Gorwood, P.
Simonneau, M.
TI Primate-Accelerated Evolutionary Genes: Novel Routes to Drug Discovery
in Psychiatric Disorders
SO CURRENT MEDICINAL CHEMISTRY
LA English
DT Review
DE Psychiatric diseases; schizophrenia; alcoholism; autism;
primate-accelerated evolution; positive selection; synaptic
transmission; drugable targets
ID CENTRAL-NERVOUS-SYSTEM; HUMAN BRAIN EVOLUTION; POSITIVE SELECTION; HUMAN
GENOME; BIPOLAR DISORDER; HOMO-SAPIENS; SUSCEPTIBILITY GENE;
NATURAL-SELECTION; SCHIZOAFFECTIVE DISORDER; ALDEHYDE DEHYDROGENASE
AB Novel molecular genetic approaches, at genome-scale in different species allowed characterizing genes that have undergone recent selection. The interest in this research field is not limited to the natural curiosity about our evolutionary past, but it is also to identify novel susceptibility genes for neuropsychiatic disorders by pointing specific human traits, such as behavioral and cognitive abilities. Hypotheses have been proposed to relate specific psychiatric disorders to the origin of modern humans, as evidenced by the theory of Crow about schizophrenia. In the present review, we will focus on genes that underwent positive selection in humans or displayed a human specific evolutionary pattern and which were reported as associated with psychiatric disorders. This will include the (1) DRD4 gene associated with attention-deficit/hyperactivity disorder, located in a locus that underwent a positive selection; the (2) GABRB2 gene, a gene associated with schizophrenia and recently reported as the target of a positive selection; (3) MARK1, a candidate gene for autism that was reported as displaying a signature of adaptative evolution in the human lineage, and (4) the ADH and ALDH2 genes which are associated with alcoholism, and for which evidence of positive selection was identified in the human lineage since the divergence between humans and chimpanzees. Identification of novel candidate genes based on recent evolution selection, coupled to genome-wide strategies designed to detect rare structural variants, could lead to a better knowledge of the molecular mechanisms of neurodevelopmental disorders and might therefore help to develop new medical chemistry.
C1 [Gorwood, P.] Ctr Hosp St Anne, CMME, F-75674 Paris 14, France.
[Moalic, J. -M.; Le Strat, Y.; Lepagnol-Bestel, A. -M.; Ramoz, N.; Loe-Mie, Y.; Maussion, G.; Gorwood, P.; Simonneau, M.] Univ Paris 05, Ctr Psychiat & Neurosci, INSERM, U675, F-75014 Paris, France.
RP Gorwood, P (reprint author), Ctr Hosp St Anne, CMME, 100 Rue Sante, F-75674 Paris 14, France.
EM p.gorwood@ch-sainte-anne.fr
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NR 158
TC 4
Z9 4
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y26, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
EMIRATES
SN 0929-8673
J9 CURR MED CHEM
JI Curr. Med. Chem.
PD MAY
PY 2010
VL 17
IS 13
BP 1300
EP 1316
PG 17
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Pharmacology &
Pharmacy
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy
GA 573QZ
UT WOS:000275931000004
PM 20166940
ER
PT J
AU van Spronsen, M
Hoogenraad, CC
AF van Spronsen, Myrrhe
Hoogenraad, Casper C.
TI Synapse Pathology in Psychiatric and Neurologic Disease
SO CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS
LA English
DT Review
DE Synaptic plasticity; Spine morphology; Synapse pathology; Neurologic
diseases; Psychiatric disorders
ID AUTISM SPECTRUM DISORDERS; FRAGILE-X-SYNDROME; DENDRITIC SPINES;
RECEPTOR TRAFFICKING; MOLECULAR-MECHANISMS; ALZHEIMERS-DISEASE;
MENTAL-RETARDATION; IN-VIVO; PLASTICITY; ADDICTION
AB Inhibitory and excitatory synapses play a fundamental role in information processing in the brain. Excitatory synapses usually are situated on dendritic spines, small membrane protrusions that harbor glutamate receptors and postsynaptic density components and help transmit electrical signals. In recent years, it has become evident that spine morphology is intimately linked to synapse function-smaller spines have smaller synapses and support reduced synaptic transmission. The relationship between synaptic signaling, spine shape, and brain function is never more apparent than when the brain becomes dysfunctional. Many psychiatric and neurologic disorders, ranging from mental retardation and autism to Alzheimer's disease and addiction, are accompanied by alterations in spine morphology and synapse number. In this review, we highlight the structure and molecular organization of synapses and discuss functional effects of synapse pathology in brain disease.
C1 [van Spronsen, Myrrhe; Hoogenraad, Casper C.] Erasmus MC, Dept Neurosci, NL-3015 GE Rotterdam, Netherlands.
RP Hoogenraad, CC (reprint author), Erasmus MC, Dept Neurosci, Dr Molewaterpl 50, NL-3015 GE Rotterdam, Netherlands.
EM c.hoogenraad@erasmusmc.nl
RI Hoogenraad, Casper/B-8866-2011
FU Netherlands Organization for Scientific Research (NWO-ALW/ECHO);
Netherlands Organization for Health Research and Development
(ZonMw-VIDI/TOP); European Science Foundation; EMBO Young Investigators
Programme (YIP); Human Frontier Science Program Career Development Award
(HFSP-CDA)
FX Dr. Hoogenraad is supported by The Netherlands Organization for
Scientific Research (NWO-ALW/ECHO), Netherlands Organization for Health
Research and Development (ZonMw-VIDI/TOP), European Science Foundation
(European Young Investigators [EURYI] Award), EMBO Young Investigators
Programme (YIP), and Human Frontier Science Program Career Development
Award (HFSP-CDA).
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NR 50
TC 99
Z9 100
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1528-4042
J9 CURR NEUROL NEUROSCI
JI Curr. Neurol. Neurosci. Rep.
PD MAY
PY 2010
VL 10
IS 3
BP 207
EP 214
DI 10.1007/s11910-010-0104-8
PG 8
WC Clinical Neurology; Neurosciences
SC Neurosciences & Neurology
GA 602AY
UT WOS:000278111700007
PM 20425036
ER
PT J
AU Williams, MA
Sachdev, PS
AF Williams, Mark A.
Sachdev, Perminder S.
TI Magnetoencephalography in neuropsychiatry: ready for application?
SO CURRENT OPINION IN PSYCHIATRY
LA English
DT Article
DE autism; dementia; depression; magnetoencephalography; schizophrenia
ID AUTISM SPECTRUM DISORDERS; MILD COGNITIVE IMPAIRMENT;
ALZHEIMERS-DISEASE; FUNCTIONAL CONNECTIVITY; SCHIZOPHRENIA; MEG; BRAIN;
SYNCHRONIZATION; OSCILLATIONS; RECORDINGS
AB Purpose of review
Magnetoencephalography (MEG) has been available for over 30 years, but the past 10 years have seen serious investigation of its use as a clinical tool. It is therefore an opportune time to review how MEG is able to contribute to neuropsychiatric research and practice.
Recent findings
We limit this review to the areas of dementia, schizophrenia, depression and autism. MEG can achieve correct classification of individuals with mild cognitive impairment versus Alzheimer's disease, may identify a marker of early disease in schizophrenia, can distinguish bipolar from major depressive disorder, and has been used to study cognitive and other deficits in autism. It provides a valuable tool to study cognitive dysfunction.
Summary
The most important aspect of MEG is the ability to record neural activity with millisecond precision, allowing coherence analysis of neural data to examine how brain areas are synchronized. Such synchrony is thought to underlie cognitive processes. As cognitive dysfunction is a common marker of neuropsychiatric disorders, MEG is emerging as an important investigatory tool in neuropsychiatry. It may also be useful clinically for early or differential diagnosis of some neuropsychiatric disorders, or for the prediction of drug effects, but more research is necessary before this becomes a clinical reality.
C1 [Williams, Mark A.] Macquarie Univ, Inst Human Cognit & Brain Sci, Macquarie Ctr Cognit Sci, Sydney, NSW 2109, Australia.
[Williams, Mark A.; Sachdev, Perminder S.] Univ New S Wales, Sch Psychiat, Sydney, NSW, Australia.
[Sachdev, Perminder S.] Prince Wales Hosp, Inst Neuropsychiat, Sydney, NSW, Australia.
RP Williams, MA (reprint author), Macquarie Univ, Inst Human Cognit & Brain Sci, Macquarie Ctr Cognit Sci, Sydney, NSW 2109, Australia.
EM mark.williams@mq.edu.au
FU National Health and Medical Research Council of Australia [568969];
Australian Research Council [DP0984919]
FX We would like to thank Anina Rich for her thoughtful comments. P. S. is
supported be a program grant ( no. 568969) from the National Health and
Medical Research Council of Australia. M. A. W. is a Queen Elizabeth II
Fellow supported by the Australian Research Council (DP0984919).
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NR 43
TC 5
Z9 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0951-7367
J9 CURR OPIN PSYCHIATR
JI Curr. Opin. Psychiatr.
PD MAY
PY 2010
VL 23
IS 3
BP 273
EP 277
DI 10.1097/YCO.0b013e328338621d
PG 5
WC Psychiatry
SC Psychiatry
GA 580LA
UT WOS:000276448500014
PM 20216218
ER
PT J
AU Liu, K
Zerubavel, N
Bearman, P
AF Liu, Kayuet
Zerubavel, Noam
Bearman, Peter
TI SOCIAL DEMOGRAPHIC CHANGE AND AUTISM
SO DEMOGRAPHY
LA English
DT Article
ID FAMILY-HISTORY; CHROMOSOMAL REARRANGEMENTS; DIAGNOSTIC SUBSTITUTION;
SPECTRUM DISORDERS; INFANTILE-AUTISM; X-CHROMOSOME; RISK-FACTORS;
POPULATION; TWIN; EPIDEMIOLOGY
AB Parental age at child's birth-which has increased for U.S. children in the 1992-2000 birth cohorts-is strongly associated with an increased risk of autism. By turning a social demographic lens on the historical patterning of concordance among twin pairs, we identify a central mechanism for this association: de novo mutations, which are deletions, insertions, and duplications of DNA in the germ cells that are not present in the parents' DNA. Along the way, we show that a demographic eye on the rising prevalence of autism leads to three major discoveries. First, the estimated heritability of autism has been dramatically overstated. Second, heritability estimates can change over remarkably short periods of time because of increases in germ cell mutations. Third, social demographic change can yield genetic changes that, at the population level, combine to contribute to the increased prevalence of autism.
C1 [Liu, Kayuet; Zerubavel, Noam; Bearman, Peter] Columbia Univ, Paul F Lazarsfeld Ctr Social Sci, New York, NY 10027 USA.
RP Bearman, P (reprint author), Columbia Univ, Paul F Lazarsfeld Ctr Social Sci, Int Affairs Bldg,420 W 118th St,MC 3355, New York, NY 10027 USA.
EM psb17@columbia.edu
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NR 51
TC 22
Z9 22
PU POPULATION ASSOC AMER
PI WASHINGTON
PA 1722 N ST NW, WASHINGTON, DC 20036 USA
SN 0070-3370
J9 DEMOGRAPHY
JI Demography
PD MAY
PY 2010
VL 47
IS 2
BP 327
EP 343
PG 17
WC Demography
SC Demography
GA 612MD
UT WOS:000278901700004
PM 20608100
ER
PT J
AU Senju, A
Southgate, V
Miura, Y
Matsui, T
Hasegawa, T
Tojo, Y
Osanai, H
Csibra, G
AF Senju, Atsushi
Southgate, Victoria
Miura, Yui
Matsui, Tomoko
Hasegawa, Toshikazu
Tojo, Yoshikuni
Osanai, Hiroo
Csibra, Gergely
TI Absence of spontaneous action anticipation by false belief attribution
in children with autism spectrum disorder
SO DEVELOPMENT AND PSYCHOPATHOLOGY
LA English
DT Article
ID ASPERGER-SYNDROME; AMYGDALA DAMAGE; MIND; INFANTS; INDIVIDUALS;
DEFICITS; RECOGNITION; 2-YEAR-OLDS; INSIGHTS; ADULTS
AB Recently, a series of studies demonstrated false belief understanding in young children through completely nonverbal measures. These studies have revealed that children younger than 3 years of age, who consistently fail the standard verbal false belief test, can anticipate others' actions based on their attributed false beliefs. The current study examined whether children with autism spectrum disorder (ASD), who are known to have difficulties in the verbal false belief test, may also show such action anticipation in a nonverbal false belief test. We presented video stimuli of an actor watching an object being hidden in a box. The object was then displaced while the actor was looking away. We recorded children's eye movements and coded whether they spontaneously anticipated the actor's subsequent behavior, which could only have been predicted if they had attributed a false belief to her. Although typically developing children correctly anticipated the action, children with ASD failed to show such action anticipation. The results suggest that children with ASD have an impairment in false belief attribution, which is independent of their verbal ability.
C1 [Senju, Atsushi] Univ London, Sch Psychol, Ctr Brain & Cognit Dev, London WC1E 7HX, England.
[Miura, Yui; Matsui, Tomoko] Kyoto Univ, Kyoto 6068501, Japan.
[Hasegawa, Toshikazu] Univ Tokyo, Tokyo 1138654, Japan.
[Tojo, Yoshikuni] Ibaraki Univ, Ibaraki, Japan.
[Osanai, Hiroo] Musashino Higashi Gakuen, Musashino, Tokyo, Japan.
[Csibra, Gergely] Cent European Univ, Budapest, Hungary.
RP Senju, A (reprint author), Univ London, Sch Psychol, Ctr Brain & Cognit Dev, Malet St, London WC1E 7HX, England.
EM a.senju@bbk.ac.uk
RI Senju, Atsushi/C-4097-2008; Csibra, Gergely/C-4345-2008
OI Senju, Atsushi/0000-0002-8081-7170; Csibra, Gergely/0000-0002-7044-3056
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NR 48
TC 23
Z9 23
PU CAMBRIDGE UNIV PRESS
PI NEW YORK
PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA
SN 0954-5794
EI 1469-2198
J9 DEV PSYCHOPATHOL
JI Dev. Psychopathol.
PD MAY
PY 2010
VL 22
IS 2
BP 353
EP 360
DI 10.1017/S0954579410000106
PG 8
WC Psychology, Developmental
SC Psychology
GA 595GF
UT WOS:000277598000010
PM 20423546
ER
PT J
AU Chen, LH
Zhou, S
AF Chen, Lihsia
Zhou, Shan
TI "CRASH"ing With the Worm: Insights Into L1CAM Functions and Mechanisms
SO DEVELOPMENTAL DYNAMICS
LA English
DT Review
DE L1CAMs; C. elegans; lad-2; sax-7; axon guidance; neural maintenance
ID CELL-ADHESION MOLECULE; X-LINKED HYDROCEPHALUS; DUCHENNE
MUSCULAR-DYSTROPHY; PERIPHERAL NERVOUS-SYSTEM; ANKYRIN-BINDING-ACTIVITY;
L1 KNOCKOUT MICE; CAENORHABDITIS-ELEGANS; C-ELEGANS; NEURITE OUTGROWTH;
CLOSE HOMOLOG
AB The L1 family of cell adhesion molecules (L1CAMs) in vertebrates has long been studied for its roles in nervous system development and function. Members of this family have been associated with distinct neurological disorders that include CRASH, autism, 3p syndrome, and schizophrenia. The conservation of L1CAMs in Drosophila and Caenorhabditis elegans allows the opportunity to take advantage of these simple model organisms and their accessible genetic manipulations to dissect L1CAM functions and mechanisms of action. This review summarizes the discoveries of L1CAMs made in C. elegans, showcasing this simple model organism as a powerful system to uncover L1CAM mechanisms and roles in healthy and diseased states. Developmental Dynamics 239:1490-1501, 2010. (C) 2010 Wiley-Liss, Inc.
C1 [Chen, Lihsia; Zhou, Shan] Univ Minnesota, Dept Genet Cell Biol & Dev, Ctr Dev Biol, Minneapolis, MN 55455 USA.
RP Chen, LH (reprint author), Univ Minnesota, Dept Genet Cell Biol & Dev, Ctr Dev Biol, Minneapolis, MN 55455 USA.
EM chenx260@umn.edu
FU National Institute of Neurological Disorders and Stroke [NS045873]
FX We thank Claire Benard and Marc Pilon for contributing the respective
micrographs of the PVQ axon flipping and twisted pharynx phenotypes
exhibited by sax-7 mutant animals, Craig Magie for providing unpublished
findings on L1CAMs in N. vectensis, and Ann Rougvie for constructive
editorial suggestions. L. Chen is supported by grant NS045873 from the
National Institute of Neurological Disorders and Stroke.
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NR 127
TC 8
Z9 21
PU WILEY-LISS
PI HOBOKEN
PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 1058-8388
J9 DEV DYNAM
JI Dev. Dyn.
PD MAY
PY 2010
VL 239
IS 5
SI SI
BP 1490
EP 1501
DI 10.1002/dvdy.22269
PG 12
WC Anatomy & Morphology; Developmental Biology
SC Anatomy & Morphology; Developmental Biology
GA 595GE
UT WOS:000277597900019
PM 20225255
ER
PT J
AU Sharrard, M
AF Sharrard, Mark
TI Clinical presentation of mitochondrial diseases in children with
progressive intellectual and neurological deterioration
SO DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY
LA English
DT Editorial Material
ID ENCEPHALOMYOPATHIES; MYOPATHIES; DISORDERS; CHILDHOOD; FEATURES;
SPECTRUM; AUTISM
C1 Sheffield Childrens Hosp, Sheffield, S Yorkshire, England.
RP Sharrard, M (reprint author), Sheffield Childrens Hosp, Sheffield, S Yorkshire, England.
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NR 9
TC 2
Z9 2
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0012-1622
J9 DEV MED CHILD NEUROL
JI Dev. Med. Child Neurol.
PD MAY
PY 2010
VL 52
IS 5
BP 407
EP 408
DI 10.1111/j.1469-8749.2009.03488.x
PG 2
WC Clinical Neurology; Pediatrics
SC Neurosciences & Neurology; Pediatrics
GA 583DS
UT WOS:000276653800002
PM 19817774
ER
PT J
AU Verity, CM
Winstone, AM
Stellitano, L
Krishnakumar, D
Will, R
McFarland, R
AF Verity, Christopher M.
Winstone, Anne Marie
Stellitano, Lesley
Krishnakumar, Deepa
Will, Robert
McFarland, Robert
TI The clinical presentation of mitochondrial diseases in children with
progressive intellectual and neurological deterioration: a national,
prospective, population-based study
SO DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY
LA English
DT Article
ID RESPIRATORY-CHAIN DISORDERS; CREUTZFELDT-JAKOB-DISEASE;
DIAGNOSTIC-CRITERIA; SPECTRUM DISORDERS; AUTISM; EPIDEMIOLOGY;
PREVALENCE; SURVEILLANCE; DYSFUNCTION; VARIANT
AB Aim
Our aim was to study the clinical presentation, mode of diagnosis, and epidemiology of mitochondrial disorders in children from the UK who have progressive intellectual and neurological deterioration (PIND).
Method
Since April 1997, we have identified patients aged 16 years or younger with suspected PIND through the monthly notification card sent to all UK consultant paediatricians by the British Paediatric Surveillance Unit. Clinical details obtained from reporting paediatricians are classified by an Expert Group.
Results
By July 2008, 2493 cases of PIND had been reported, among which there were 112 children (69 males, 43 females) with mitochondrial diseases presenting between birth and 14 years 7 months (median 12mo), divided into 13 subgroups. In some instances, clinical features were characteristic of mitochondrial disease, but many children presented non-specifically with combinations of developmental delay, hypotonia, failure to thrive, and seizures; 16 children had multisystem disease at presentation. Mortality was high: 40 children had died. Blood and/or cerebrospinal fluid lactate measurements were abnormal in 87 children, and 47 of 78 brain magnetic resonance images showed increased basal ganglia signal. Definite diagnoses were usually made by muscle enzyme or genetic studies.
Interpretation
This is a unique population-based study of the mitochondrial disorders that cause childhood neurodegenerative disease. It provides detailed information about the clinical presentation and investigation of these complex cases.
C1 [Verity, Christopher M.] Addenbrookes Hosp, Child Dev Ctr, PIND Surveillance Grp, Cambridge CB2 0QQ, England.
[Will, Robert] Western Gen Hosp, Natl Creutzfeldt Jakob Dis Surveillance Unit, Edinburgh EH4 2XU, Midlothian, Scotland.
[McFarland, Robert] Newcastle Univ, Mitochondrial Res Grp, Newcastle Upon Tyne, Tyne & Wear, England.
RP Verity, CM (reprint author), Addenbrookes Hosp, Child Dev Ctr, PIND Surveillance Grp, Box 107,Hills Rd, Cambridge CB2 0QQ, England.
EM christopher.verity@addenbrookes.nhs.uk
FU Department of Health in England
FX The PIND study is funded by the Department of Health in England. Many
thanks to the BPSU of the Royal College of Paediatrics and Child Health
and to Mr Richard Lynn, the Scientific Coordinator. The authors also
wish to thank past and present members of the Expert Group. Our grateful
thanks go to all the paediatricians who have reported cases to the
study.
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NR 22
TC 8
Z9 8
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0012-1622
J9 DEV MED CHILD NEUROL
JI Dev. Med. Child Neurol.
PD MAY
PY 2010
VL 52
IS 5
BP 434
EP 440
DI 10.1111/j.1469-8749.2009.03463.x
PG 7
WC Clinical Neurology; Pediatrics
SC Neurosciences & Neurology; Pediatrics
GA 583DS
UT WOS:000276653800009
PM 19747204
ER
PT J
AU Hunter, JW
Mullen, GP
McManus, JR
Heatherly, JM
Duke, A
Rand, JB
AF Hunter, Jerrod W.
Mullen, Gregory P.
McManus, John R.
Heatherly, Jessica M.
Duke, Angie
Rand, James B.
TI Neuroligin-deficient mutants of C. elegans have sensory processing
deficits and are hypersensitive to oxidative stress and mercury toxicity
SO DISEASE MODELS & MECHANISMS
LA English
DT Article
ID NEMATODE CAENORHABDITIS-ELEGANS; AUTISM SPECTRUM DISORDER; HOMEODOMAIN
PROTEIN; GLUTAMATE-RECEPTOR; BETA-NEUREXINS; SYNAPTIC-TRANSMISSION;
LIPID-PEROXIDATION; SENSITIVE MUTANT; NERVOUS-SYSTEM; MOTOR-NEURONS
AB Neuroligins are postsynaptic cell adhesion proteins that bind specifically to presynaptic membrane proteins called neurexins. Mutations in human neuroligin genes are associated with autism spectrum disorders in some families. The nematode Caenorhabditis elegans has a single neuroligin gene (nlg-1), and approximately a sixth of C. elegans neurons, including some sensory neurons, interneurons and a subset of cholinergic motor neurons, express a neuroligin transcriptional reporter. Neuroligin-deficient mutants of C. elegans are viable, and they do not appear deficient in any major motor functions. However, neuroligin mutants are defective in a subset of sensory behaviors and sensory processing, and are hypersensitive to oxidative stress and mercury compounds; the behavioral deficits are strikingly similar to traits frequently associated with autism spectrum disorders. Our results suggest a possible link between genetic defects in synapse formation or function, and sensitivity to environmental factors in the development of autism spectrum disorders.
C1 [Hunter, Jerrod W.; Mullen, Gregory P.; McManus, John R.; Heatherly, Jessica M.; Duke, Angie; Rand, James B.] Oklahoma Med Res Fdn, Genet Models Dis Res Program, Oklahoma City, OK 73104 USA.
[Hunter, Jerrod W.; Rand, James B.] Univ Oklahoma, Hlth Sci Ctr, Dept Cell Biol, Oklahoma City, OK 73104 USA.
[Heatherly, Jessica M.; Rand, James B.] Univ Oklahoma, Hlth Sci Ctr, Oklahoma Ctr Neurosci, Oklahoma City, OK 73104 USA.
RP Rand, JB (reprint author), Oklahoma Med Res Fdn, Genet Models Dis Res Program, 825 NE 13th St, Oklahoma City, OK 73104 USA.
EM James-Rand@omrf.org
FU Autism Speaks; National Center for Research Resources
FX These studies were supported by a research grant from Autism Speaks.
Some strains were obtained from the Caenorhabditis Genetics Center,
which is supported by the National Center for Research Resources.
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Z9 31
PU COMPANY OF BIOLOGISTS LTD
PI CAMBRIDGE
PA BIDDER BUILDING CAMBRIDGE COMMERCIAL PARK COWLEY RD, CAMBRIDGE CB4 4DL,
CAMBS, ENGLAND
SN 1754-8403
J9 DIS MODEL MECH
JI Dis. Model. Mech.
PD MAY-JUN
PY 2010
VL 3
IS 5-6
BP 366
EP 376
DI 10.1242/dmm.003442
PG 11
WC Cell Biology; Pathology
SC Cell Biology; Pathology
GA 622YA
UT WOS:000279701700020
PM 20083577
ER
PT J
AU Hagberg, KW
Jick, H
AF Hagberg, Katrina W.
Jick, Hershel
TI Autism in the UK for Birth Cohorts 1988-2001
SO EPIDEMIOLOGY
LA English
DT Letter
ID PRACTICE RESEARCH DATABASE; DIAGNOSIS
C1 [Hagberg, Katrina W.; Jick, Hershel] Boston Univ, Sch Med, Boston Collaborat Drug Surveillance Program, Lexington, MA USA.
RP Hagberg, KW (reprint author), Boston Univ, Sch Med, Boston Collaborat Drug Surveillance Program, Lexington, MA USA.
EM hjick@bu.edu
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NR 8
TC 4
Z9 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1044-3983
J9 EPIDEMIOLOGY
JI Epidemiology
PD MAY
PY 2010
VL 21
IS 3
BP 426
EP 427
DI 10.1097/EDE.0b013e3181d61dd9
PG 2
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 588LL
UT WOS:000277071500023
PM 20386177
ER
PT J
AU Taurines, R
Thome, J
Duvigneau, JC
Forbes-Robertson, S
Yang, LY
Klampfl, K
Romanos, J
Muller, S
Gerlach, M
Mehler-Wex, C
AF Taurines, Regina
Thome, Johannes
Duvigneau, J. Catharina
Forbes-Robertson, Sarah
Yang, Liya
Klampfl, Karin
Romanos, Jasmin
Mueller, Sabine
Gerlach, Manfred
Mehler-Wex, Claudia
TI Expression analyses of the mitochondrial complex I 75-kDa subunit in
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as a potential biomarker for early onset schizophrenia
SO EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
LA English
DT Article
DE Biological marker; Mitochondrial complex I; 75-kDa subunit; Early onset
schizophrenia; Autistic spectrum disorder
ID DIAGNOSTIC OBSERVATION SCHEDULE; CEREBRAL GLUCOSE-METABOLISM;
ELECTRON-TRANSPORT CHAIN; OXIDATIVE STRESS; PERIPHERAL MARKER;
GENE-EXPRESSION; BRAIN; DYSFUNCTION; ABNORMALITIES; NEUROLEPTICS
AB Searching for a peripheral biological marker for schizophrenia, we previously reported on elevated mitochondrial complex I 75-kDa subunit mRNA-blood concentrations in early onset schizophrenia (EOS). The aim of this study was to further evaluate the utility of this gene as a potential marker for schizophrenia. Both-schizophrenia and autism-are suggested to be neuronal maldevelopmental disorders with reports of mitochondrial dysfunction and increased oxidative stress. Therefore we have investigated the expression levels of mitochondrial complex I 75-kDa subunit mRNA in whole blood of children with autistic spectrum disorder (ASD) and a group of adolescent acute first-episode EOS patients in comparison to matched controls. We have found that compared to the respective controls only the group of EOS patients-and not the ASD group-showed a significantly altered expression of the complex I 75-kDa subunit mRNA. Although further studies are necessary to test for the specificity of this marker, our findings point to the potential use of the mitochondrial complex I as a biomarker for schizophrenia.
C1 [Taurines, Regina; Klampfl, Karin; Romanos, Jasmin; Gerlach, Manfred] Univ Wurzburg, Dept Child & Adolescent Psychiat & Psychotherapy, D-97080 Wurzburg, Germany.
[Thome, Johannes; Forbes-Robertson, Sarah; Yang, Liya] Univ Coll Swansea, Inst Life Sci, Sch Med, Swansea SA2 8PP, W Glam, Wales.
[Duvigneau, J. Catharina] Univ Vet Med Vienna, Dept Biomed Sci, Vienna, Austria.
[Mueller, Sabine; Mehler-Wex, Claudia] Univ Ulm, Dept Child & Adolescent Psychiat & Psychotherapy, D-89075 Ulm, Germany.
RP Taurines, R (reprint author), Univ Wurzburg, Dept Child & Adolescent Psychiat & Psychotherapy, Fuchsleinstr 15, D-97080 Wurzburg, Germany.
EM Huennerkopf@kjp.uni-wuerzburg.de; j.thome@swansea.ac.uk;
catharina.duvigneau@vetmeduni.ac.at; forbes-robertson@swansea.ac.uk;
liyayangdr@hotmail.com; klampfl@kjp.uni-wuerzburg.de;
romanos2@kjp.uni-wuerzburg.de; sabine.mueller@uniklinik-ulm.de;
manfred.gerlach@uni-wuerzburg.de; claudia.mehler-wex@uniklinik-ulm.de
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NR 52
TC 7
Z9 8
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1018-8827
J9 EUR CHILD ADOLES PSY
JI Eur. Child Adolesc. Psych.
PD MAY
PY 2010
VL 19
IS 5
BP 441
EP 448
DI 10.1007/s00787-009-0074-z
PG 8
WC Psychology, Developmental; Pediatrics; Psychiatry
SC Psychology; Pediatrics; Psychiatry
GA 592WR
UT WOS:000277412900004
PM 19894076
ER
PT J
AU Watanabe, K
Ikeda, H
Miyao, M
AF Watanabe, Katsumi
Ikeda, Hanako
Miyao, Masutomo
TI Learning efficacy of explicit visuomotor sequences in children with
attention-deficit/hyperactivity disorder and Asperger syndrome
SO EXPERIMENTAL BRAIN RESEARCH
LA English
DT Article
DE Visuomotor sequence learning; Developmental disorder; Asperger syndrome;
Attention-deficit/hyperactivity disorder; Learning curve
ID DEFICIT HYPERACTIVITY DISORDER; HIGH-FUNCTIONING AUTISM; DEVELOPMENTAL
DISORDERS; EXECUTIVE FUNCTIONS; MOTOR-AREA; ADHD; INHIBITION;
INTERFERENCE; ACTIVATION; SPECTRUM
AB Developmental disorders such as attention-deficit/hyperactivity disorder (ADHD) and Asperger syndrome (AS) are often associated with learning disabilities. This study investigated the explicit learning of visuomotor sequences in 17 ADHD children (mean age 12.1), 21 AS children (mean age 12.7), and 15 typically developing children (mean age: 12.3). The participants were required to explore a hidden sequence of button presses by trial and error and elaborate the learned sequence (2 x 10 task: Hikosaka et al. 1996). The results indicated that although ADHD and AS children had a tendency of repeating the same errors and took longer to complete a sequence, both showed a degree and pattern of improvement in accuracy and speed similar to that of typically developing children. These results suggest that the explicit learning of visuomotor sequence in ADHD and AS patients is largely unimpaired.
C1 [Watanabe, Katsumi; Ikeda, Hanako] Univ Tokyo, Res Ctr Adv Sci & Technol, Meguro Ku, Tokyo 1538904, Japan.
[Watanabe, Katsumi] Natl Inst Adv Ind Sci & Technol, Tsukuba, Japan.
[Watanabe, Katsumi] Japan Sci & Technol Agcy, Saitama, Japan.
[Ikeda, Hanako] Japan Soc Promot Sci, Tokyo, Japan.
[Miyao, Masutomo] Natl Ctr Child Hlth & Dev, Dept Dev & Behav Pediat, Tokyo, Japan.
RP Watanabe, K (reprint author), Univ Tokyo, Res Ctr Adv Sci & Technol, Meguro Ku, 4-6-1 Komaba, Tokyo 1538904, Japan.
EM kw@fennel.rcast.u-tokyo.ac.jp
FU Japan Science and Technology Agency; Japan Society for the Promotion of
Science; MEXT Knowledge Custer Initiative (Toyama/Ishikawa Region); New
Technology Foundation
FX This research was supported by Japan Science and Technology Agency,
Japan Society for the Promotion of Science, MEXT Knowledge Custer
Initiative (Toyama/Ishikawa Region), Grant-in-Aids for Scientific
Research from the MEXT, and New Technology Foundation.
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NR 36
TC 6
Z9 6
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0014-4819
J9 EXP BRAIN RES
JI Exp. Brain Res.
PD MAY
PY 2010
VL 203
IS 1
BP 233
EP 239
DI 10.1007/s00221-010-2217-3
PG 7
WC Neurosciences
SC Neurosciences & Neurology
GA 591FC
UT WOS:000277283800022
PM 20339839
ER
PT J
AU Jyonouchi, H
AF Jyonouchi, Harumi
TI Autism spectrum disorders and allergy: observation from a pediatric
allergy/immunology clinic
SO EXPERT REVIEW OF CLINICAL IMMUNOLOGY
LA English
DT Article
DE allergy; asthma; autism spectrum disorders; IgE-mediated allergic
reactions; non-IgE-mediated 'allergic' reactions
ID ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; REGULATORY T-CELLS; INDUCED
ENTEROCOLITIS SYNDROME; POPULATION-BASED SAMPLE; CELIAC-DISEASE; FOOD
ALLERGY; MENTAL-RETARDATION; ATOPIC ECZEMA; GASTROINTESTINAL SYMPTOMS;
PSYCHIATRIC COMORBIDITY
AB IgE-mediated allergic diseases (e.g., allergic rhinoconjunctivitis, atopic asthma and food allergy) are prevalent (up to 30%) in the general population and are increasing in developed countries. In infants and young children, non-IgE-mediated food allergy is also prevalent. In addition to easily recognized organ-specific symptoms, allergic diseases can cause neuropsychiatric symptoms, such as irritability and hyperactivity, in otherwise healthy individuals. This is also likely to occur in children with autism spectrum disorder (ASD). Moreover, the discomfort and pain associated with allergic diseases could aggravate behavioral symptoms in ASD children. Allergic conditions are easily treatable; however, ASD children may be underdiagnosed and/or undertreated for allergic and other common childhood diseases, in part due to their impaired communication skills. Practicing physicians should be aware of the potential impact of allergic diseases on behavioral symptoms and cognitive activity in ASD children. However, they also need to be aware that certain symptoms often attributed to 'allergy' by caregivers may not be immune mediated and should understand that behavioral symptoms can also be affected by many non-IgE-mediated causes.
C1 Univ Med & Dent New Jersey, New Jersey Med Sch, Newark, NJ 07101 USA.
RP Jyonouchi, H (reprint author), Univ Med & Dent New Jersey, New Jersey Med Sch, 185 S Orange Ave, Newark, NJ 07101 USA.
EM jyanouha@umdnj.edu
FU Autism Research Institute (San Diego, CA, USA); Jonty Foundation (St
Paul, MN, USA)
FX This study was partly supported by funding from the Autism Research
Institute (San Diego, CA, USA) and the Jonty Foundation (St Paul, MN,
USA). The author is thankful to Lisa Huguenin for critically reviewing
this manuscript. The author has no other relevant affiliations or
financial involvement with any organization or entity with a financial
interest in or financial conflict with the subject matter or materials
discussed in the manuscript apart from those disclosed.
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NR 132
TC 16
Z9 16
PU EXPERT REVIEWS
PI LONDON
PA UNITEC HOUSE, 3RD FL, 2 ALBERT PLACE, FINCHLEY CENTRAL, LONDON N3 1QB,
ENGLAND
SN 1744-666X
J9 EXPERT REV CLIN IMMU
JI Expert Rev. Clin. Immunol.
PD MAY
PY 2010
VL 6
IS 3
BP 397
EP 411
DI 10.1586/ECI.10.18
PG 15
WC Immunology
SC Immunology
GA 602VI
UT WOS:000278166600015
PM 20441426
ER
PT J
AU Chatterjee, A
O'Keefe, C
AF Chatterjee, Archana
O'Keefe, Catherine
TI Current controversies in the USA regarding vaccine safety
SO EXPERT REVIEW OF VACCINES
LA English
DT Review
DE controversies; immunizations; vaccine safety; vaccines
ID HUMAN-PAPILLOMAVIRUS VACCINE; CAUSAL ASSOCIATION; MONONUCLEAR-CELLS; HPV
VACCINATION; IMMUNE-SYSTEM; UNITED-STATES; MEASLES-VIRUS; IMMUNIZATION;
PERTUSSIS; CHILDREN
AB As a result of the vaccines discovered in the 20th Century, parents and many healthcare providers of the 21st Century have limited or no experience with the devastating effects of diseases such as polio, smallpox or measles. Fear of disease has shifted to concerns regarding vaccine safety. Scientific evidence has refuted many of the misconceptions regarding vaccine safety; however, parental refusal of vaccines is increasing. Here we review six of the most prevalent controversies surrounding vaccine safety: the proposed causal relationship between receipt of the measles mumps rubella vaccine and autism; thimerosal as a potential trigger for autism; religious objection based on some vaccine viruses being grown in cell lines from aborted fetal tissues; parental worries that use of the human papillomavirus vaccine may lead to youth promiscuity; fears regarding the purported association between pertussis vaccination and adverse neurological outcomes; and concerns regarding too many vaccines overloading or weakening the infant immune system. Healthcare providers are ideally positioned to correct these misconceptions, but they must recognize and acknowledge parents' concerns, educate themselves on the latest scientific research that addresses these, and dedicate sufficient time to discuss vaccine safety with worried parents.
C1 [Chatterjee, Archana] Creighton Univ, Sch Med, Dept Pediat, Omaha, NE 68131 USA.
[O'Keefe, Catherine] Creighton Univ, Sch Nursing, Omaha, NE 68131 USA.
[O'Keefe, Catherine] Creighton Univ, Div Pediat Infect Dis, Omaha, NE 68131 USA.
RP Chatterjee, A (reprint author), Creighton Univ, Sch Med, Dept Pediat, 601 N 30th St,Suite 2329, Omaha, NE 68131 USA.
EM achatter@creighton.edu
FU Merck; GlaxoSmithKline; Sanofi Pasteur; Novartis; Wyeth; MedImmune
FX Archana Chatterjee has received research grants from Merck,
GlaxoSmithKline, Sanofi Pasteur, Novartis, Wyeth and MedImmune. She has
also served on the Speakers Bureau for Merck, GlaxoSmithKline, Sanofi
Pasteur, Wyeth and MedImmune. She has served on ad hoc Advisory Boards
for Merck, GlaxoSmithKline, Novartis, Sanofi Pasteur and MedImmune.
Catherine O'Keefe is involved in research studies funded by Merck,
GlaxoSmithKline, Sanofi Pasteur, Novartis, Wyeth and MedImmune. The
authors have no other relevant affiliations or financial involvement
with any organization or entity with a financial interest in or
financial conflict with the subject matter or materials' discussed in
the manuscript apart from those disclosed.
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ALUMINUM VACCINATION
CANC SLUTS DOES HPV
DRUG USE SEXUAL BEHA
MERCURY ALUMINUM SQU
NR 62
TC 23
Z9 25
PU EXPERT REVIEWS
PI LONDON
PA UNITEC HOUSE, 3RD FL, 2 ALBERT PLACE, FINCHLEY CENTRAL, LONDON N3 1QB,
ENGLAND
SN 1476-0584
J9 EXPERT REV VACCINES
JI Expert Rev. Vaccines
PD MAY
PY 2010
VL 9
IS 5
BP 497
EP 502
DI 10.1586/ERV.10.36
PG 6
WC Immunology
SC Immunology
GA 599RT
UT WOS:000277931500012
PM 20450324
ER
PT J
AU Fournier, KA
Kimberg, CI
Radonovich, KJ
Tillman, MD
Chow, JW
Lewis, MH
Bodfish, JW
Hass, CJ
AF Fournier, Kimberly A.
Kimberg, Cara I.
Radonovich, Krestin J.
Tillman, Mark D.
Chow, John W.
Lewis, Mark H.
Bodfish, James W.
Hass, Chris J.
TI Decreased static and dynamic postural control in children with autism
spectrum disorders
SO GAIT & POSTURE
LA English
DT Article
DE Center of pressure (COP); Center of mass (COM); Posture; Gait
initiation; Stability
ID HIGH-FUNCTIONING AUTISM; PARKINSONS-DISEASE; GAIT INITIATION;
ASPERGERS-DISORDER; BALANCE; YOUNG; ADULTS; STABILITY; BEHAVIOR; OLDER
AB purpose of this study was to investigate postural control in children with Autism Spectrum Disorders (ASD) during static and dynamic postural challenges. We evaluated postural sway during quiet stance and the center of pressure (COP) shift mechanism during gait initiation for 13 children with ASD and 12 age-matched typically developing (TD) children. Children with ASD produced 438% greater normalized mediolateral sway (p<0.05) and 104% greater normalized anteroposterior sway (p < 0.05) than TD children. Consequently, normalized sway area was also significantly greater (p < 0.05) in the group with ASD. Similarly, the maximum separation between the COP and center of mass (COM) during quiet stance was 100% greater in the anteroposterior direction (p < 0.05) and 146% greater in the resultant direction (p<0.05) for children with ASD. No significant difference was observed in the mediolateral direction, in spite of the 123% greater separation detected in children with ASD. During gait initiation, no group differences were detected in the posterior COP shift mechanism, suggesting the mechanism for generating forward momentum is intact. However, significantly smaller lateral COP shifts (p < 0.05) were observed in children with ASD, suggesting instability or an alternative strategy for generating momentum in the mediolateral direction. These results help to clarify some discrepancies in the literature, suggesting an impaired or immature control of posture, even under the most basic conditions when no afferent or sensory information have been removed or modified. Additionally, these findings provide new insight into dynamic balance in children with ASD. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Fournier, Kimberly A.] Univ Texas Pan Amer, Dept Hlth & Kinesiol, Edinburg, TX 78541 USA.
[Kimberg, Cara I.; Radonovich, Krestin J.; Lewis, Mark H.] Univ Florida, Dept Psychiat, Gainesville, FL 32611 USA.
[Tillman, Mark D.; Hass, Chris J.] Univ Florida, Dept Appl Physiol & Kinesiol, Gainesville, FL 32611 USA.
[Chow, John W.] Mississippi Methodist Rehabil Ctr, Jackson, MS USA.
[Bodfish, James W.] Univ N Carolina, Dept Psychiat, Chapel Hill, NC USA.
RP Fournier, KA (reprint author), Univ Texas Pan Amer, Dept Hlth & Kinesiol, Edinburg, TX 78541 USA.
EM fournierka@utpa.edu
RI Fournier, Kimberly/E-5052-2013
OI Fournier, Kimberly/0000-0001-5830-6131
FU Organization for Autism Research; National Institute of Health [R01
MH073402]
FX This study was supported in part by grants from the Organization for
Autism Research (Graduate Student Grant 2006) and the National Institute
of Health (R01 MH073402 - Bodfish). The content of this manuscript is
solely the responsibility of the authors and does not necessarily
represent the official views of OAR or NIH. We would like to thank
Michelle Benjamin and Jacquelyn Selbst for their assistance with data
collection.
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NR 30
TC 25
Z9 25
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
IRELAND
SN 0966-6362
J9 GAIT POSTURE
JI Gait Posture
PD MAY
PY 2010
VL 32
IS 1
BP 6
EP 9
DI 10.1016/j.gaitpost.2010.02.007
PG 4
WC Neurosciences; Orthopedics; Sport Sciences
SC Neurosciences & Neurology; Orthopedics; Sport Sciences
GA 621LT
UT WOS:000279581000002
PM 20400311
ER
PT J
AU Mazumdar, S
King, M
Liu, KY
Zerubavel, N
Bearman, P
AF Mazumdar, Soumya
King, Marissa
Liu, Ka-Yuet
Zerubavel, Noam
Bearman, Peter
TI The spatial structure of autism in California, 1993-2001
SO HEALTH & PLACE
LA English
DT Article
DE Autism; Clusters; Spatial; GIS (Geographical Information Systems);
California
ID ENVIRONMENTAL MERCURY RELEASE; SPECTRUM DISORDERS; PREVALENCE;
POPULATION; MORTALITY; CLUSTERS; UPDATE; RATES; AREA; RISK
AB This article identifies significant high-risk clusters of autism based on residence at birth in California for children born from 1993 to 2001. These clusters are geographically stable. Children born in a primary cluster are at four times greater risk for autism than children living in other parts of the state. This is comparable to the difference between males and females and twice the risk estimated for maternal age over 40. In every year roughly 3% of the new caseload of autism in California arises from the primary cluster we identify-a small zone 20 km by 50 km. We identify a set of secondary clusters that support the existence of the primary clusters. The identification of robust spatial clusters indicates that autism does not arise from a global treatment and indicates that important drivers of increased autism prevalence are located at the local level. (C) 2010 Elsevier Ltd. All rights reserved.
C1 [Mazumdar, Soumya; King, Marissa; Liu, Ka-Yuet; Zerubavel, Noam; Bearman, Peter] Columbia Univ, Inst Social & Econ Res & Policy, New York, NY 10027 USA.
RP Bearman, P (reprint author), Columbia Univ, Inst Social & Econ Res & Policy, New York, NY 10027 USA.
EM soumyamazumdar@yahoo.com; mdk2101@columbia.edu; kyl2111@columbia.edu;
nz2104@columbia.edu; psb17@columbia.edu
RI Mazumdar, Soumya/D-3017-2013
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NR 42
TC 15
Z9 15
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1353-8292
EI 1873-2054
J9 HEALTH PLACE
JI Health Place
PD MAY
PY 2010
VL 16
IS 3
BP 539
EP 546
DI 10.1016/j.healthplace.2009.12.014
PG 8
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 601FU
UT WOS:000278044500013
PM 20097113
ER
PT J
AU [Anonymous]
AF [Anonymous]
TI Court finds no Vaccines-autism link
SO HUMAN VACCINES
LA English
DT News Item
NR 0
TC 0
Z9 0
PU LANDES BIOSCIENCE
PI AUSTIN
PA 1806 RIO GRANDE ST, AUSTIN, TX 78702 USA
SN 1554-8600
J9 HUM VACCINES
JI Hum. Vaccines
PD MAY
PY 2010
VL 6
IS 5
BP 368
EP 368
PG 1
WC Biotechnology & Applied Microbiology; Immunology
SC Biotechnology & Applied Microbiology; Immunology
GA 652GW
UT WOS:000281992700002
ER
PT J
AU Poon, JK
LaRosa, AC
Pai, GS
AF Poon, Jennifer K.
LaRosa, Angela C.
Pai, G. Shashidhar
TI Developmental Delay: Timely Identification and Assessment
SO INDIAN PEDIATRICS
LA English
DT Review
ID LOW-BIRTH-WEIGHT; AUTISM SPECTRUM DISORDERS; DEVELOPMENT PROGRAM; INFANT
HEALTH; EARLY INTERVENTION; PREMATURE-INFANTS; MENTAL-RETARDATION;
YOUNG-CHILDREN; FOLLOW-UP; RECOMMENDATIONS
AB This paper outlines the prevalence of developmental delay in children and discusses the recent literature regarding the benefits of early identification and evidence based strategies for developmental surveillance and screening. We describe a systematic approach to the child with developmental delay and the optimal methodology for arriving at the etiologic basis for the delay. A review of the most up-to-date and relevant literature was completed using Pub Med, online databases, and texts. The medical evaluation with specific emphasis on the most recent recommendations for genetic, laboratory and imaging studies is described. The American Academy of Pediatrics algorithm for developmental surveillance and screening is discussed with consideration for the importance of culturally relevant screening tools across populations. In addition, specific screening tools are briefly discussed that may prove beneficial to the primary care provider as he/she implements routine surveillance and screening.
C1 [Poon, Jennifer K.; LaRosa, Angela C.; Pai, G. Shashidhar] Med Univ S Carolina, Div Genet & Dev Behav Pediat, Charleston, SC 29425 USA.
RP Poon, JK (reprint author), 135 Rutledge Ave,MSC 561, Charleston, SC 29425 USA.
EM poon@musc.edu
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NR 46
TC 4
Z9 4
PU INDIAN ACAD PEDIATRICS
PI NEW DELHI
PA MAULANA AZAD MEDICAL COLLEGE, DEPT PEDIATRICS, NEW DELHI, 110 002, INDIA
SN 0019-6061
J9 INDIAN PEDIATR
JI Indian Pediatrics
PD MAY
PY 2010
VL 47
IS 5
BP 415
EP 422
PG 8
WC Pediatrics
SC Pediatrics
GA 601TI
UT WOS:000278086800007
PM 20519787
ER
PT J
AU Kostyuk, N
Rajnarayanan, RV
Isokpehi, RD
Cohly, HH
AF Kostyuk, Nataliya
Rajnarayanan, Rajendram V.
Isokpehi, Raphael D.
Cohly, Hari H.
TI Autism from a Biometric Perspective
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Article
DE autism; biometric evaluation; electro-photonic emission; gas discharge
visualization (GDV)
ID CEREBRAL-BLOOD-FLOW; CHILDHOOD AUTISM; BRAIN; DISCHARGE
AB Purpose: The aim of this pilot study was to test autistic children, siblings and their parents using a biometric device based on the gas discharge visualization (GDV) technique in order to assess their psycho-emotional and physiological functional state based on the activity of the autonomic nervous system. Hypothesis: We hypothesize that the biometric assessment based on GDV will enable us: (1) to evaluate some specific features associated with autism spectrum disorder (ASD) as well as to compare autistic children to their siblings and to controls; (2) to analyze the differences in individual values of parents of autistic children versus parents of normal children. Results: Out of total of 48 acupuncture points present on ten fingertips of both hands and associated to organs/organ systems, autistic children differed significantly from controls (p < 0.05) in 36 (images without filter) and 12 (images with filter), siblings differed significantly from controls (p < 0.05) in 12 (images without filter) and seven (images with filter), autistic children differed significantly (p < 0.05) from siblings in eight (images without filter) and one (images with filter), fathers of autistic children differed significantly (p < 0.05) from controls in 14 (images without filter) and three (images with filter) and mothers of autistic children differed significantly (p < 0.05) from controls in five (images without filter) and nine (images with filter) acupuncture points. Conclusions: All compared groups have shown significant difference on both psycho-emotional (images without filter) and physiological (images with filter) levels. However, the differences between autistic children and controls expressed on psycho-emotional level were the most significant as compared to the other groups. Therefore, the activity of the sympathetic autonomic nervous system is significantly altered in children with autism. The biometric method based on GDV is a promising step in autism research that may lead towards creating a disease profile and identify unique signature/biomarker for autism. Further work should involve more participants in order to augment our findings.
C1 [Kostyuk, Nataliya; Isokpehi, Raphael D.; Cohly, Hari H.] Jackson State Univ, Ctr Bioinformat & Computat Biol, Dept Biol, Jackson, MS 39217 USA.
[Rajnarayanan, Rajendram V.] SUNY Buffalo, Sch Med & Biomed Sci, Buffalo, NY 14214 USA.
RP Cohly, HH (reprint author), Jackson State Univ, Ctr Bioinformat & Computat Biol, Dept Biol, 1400 JR Lynch St,Box 18540, Jackson, MS 39217 USA.
EM nkostyuk@gmail.com; rajendra@buffalo.edu; raphael.isokpehi@jsums.edu;
hari.cohly@jsums.edu
FU EPSCoR, National Science Foundation [EPS-0903787]; Research Centers in
Minority Institutions (RCMI)-Center for Environmental Health
[G12RR13459]
FX EPSCoR, National Science Foundation (EPS-0903787) and Research Centers
in Minority Institutions (RCMI)-Center for Environmental Health
(NIH-NCRR G12RR13459). We acknowledge the RCMI statistical core lab for
the use of SAS version 9.1 for data analysis. Additionally, we thank
Jennifer Sims, Baraka Williams and Dr. Mark Yeager and Helen Mann for
their assistance in obtaining data from autistic children and their
family members and in proofreading the manuscript.
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CONSTIPATION BEHAV S
NR 34
TC 1
Z9 1
PU MDPI AG
PI BASEL
PA POSTFACH, CH-4005 BASEL, SWITZERLAND
SN 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD MAY
PY 2010
VL 7
IS 5
BP 1984
EP 1995
DI 10.3390/ijerph7051984
PG 12
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA 601YW
UT WOS:000278105200009
PM 20623006
ER
PT J
AU Loucas, T
Riches, NG
Charman, T
Pickles, A
Simonoff, E
Chandler, S
Baird, G
AF Loucas, Tom
Riches, Nick Greatorex
Charman, Tony
Pickles, Andrew
Simonoff, Emily
Chandler, Susie
Baird, Gillian
TI Speech perception and phonological short-term memory capacity in
language impairment: preliminary evidence from adolescents with specific
language impairment (SLI) and autism spectrum disorders (ASD)
SO INTERNATIONAL JOURNAL OF LANGUAGE & COMMUNICATION DISORDERS
LA English
DT Article
DE language disorders; specific language impairment; autism spectrum
disorders; non-word repetition tasks; working memory; speech perception.
ID PERVASIVE DEVELOPMENTAL DISORDERS; WORKING-MEMORY; NONWORD REPETITION;
PRESCHOOL-CHILDREN; DEFICITS; INDIVIDUALS; RECOGNITION; PREVALENCE;
VOCABULARY; ATTENTION
AB Aims: This study aimed to investigate the contributions of PSTM and speech perception in non-word processing and whether individuals with SLI and ASD plus language impairment (ALI) show similar or different patterns of deficit in these cognitive processes.
Method & Procedures: Three groups of adolescents (aged 14-17 years), 14 with SLI, 16 with ALI, and 17 age and non-verbal IQ matched typically developing (TD) controls, made speeded discriminations between non-word pairs. Stimuli varied in PSTM load (two- or four-syllables) and speech perception load (mismatches on a word-initial or word-medial segment).
Outcomes & Results: Reaction times showed effects of both non-word length and mismatch position and these factors interacted: four-syllable and word-initial mismatch stimuli resulted in the slowest decisions. Individuals with language impairment showed the same pattern of performance as those with typical development in the reaction time data. A marginal interaction between group and item length was driven by the SLI and ALI groups being less accurate with long items than short ones, a difference not found in the TD group.
Conclusions & Implications: Non-word discrimination suggests that there are similarities and differences between adolescents with SLI and ALI and their TD peers. Reaction times appear to be affected by increasing PSTM and speech perception loads in a similar way. However, there was some, albeit weaker, evidence that adolescents with SLI and ALI are less accurate than TD individuals, with both showing an effect of PSTM load. This may indicate, at some level, the processing substrate supporting both PSTM and speech perception is intact in adolescents with SLI and ALI, but also in both there may be impaired access to PSTM resources.
C1 [Loucas, Tom] Univ Reading, Sch Psychol & Clin Language Sci, Reading RG6 6AL, Berks, England.
[Charman, Tony] Univ London, Inst Educ, London WC1N 1AZ, England.
[Pickles, Andrew] Univ Manchester, Manchester, Lancs, England.
[Simonoff, Emily] Inst Psychiat, London, England.
[Chandler, Susie] UCL Inst Child Hlth, London, England.
[Baird, Gillian] Guys & St Thomas NHS Fdn Trust, London, England.
RP Loucas, T (reprint author), Univ Reading, Sch Psychol & Clin Language Sci, Reading RG6 6AL, Berks, England.
EM t.loucas@reading.ac.uk
RI Pickles, Andrew/A-9625-2011; Simonoff, Emily/B-7593-2011; Charman,
Tony/A-2085-2014
OI Pickles, Andrew/0000-0003-1283-0346; Charman, Tony/0000-0003-1993-6549
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NR 44
TC 5
Z9 5
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 1368-2822
J9 INT J LANG COMM DIS
JI Int. J. Lang. Commun. Disord.
PD MAY
PY 2010
VL 45
IS 3
BP 275
EP +
DI 10.3109/13682820902936433
PG 12
WC Audiology & Speech-Language Pathology; Linguistics; Rehabilitation
SC Audiology & Speech-Language Pathology; Linguistics; Rehabilitation
GA 587QA
UT WOS:000277006300002
PM 20131963
ER
PT J
AU Marui, T
Funatogawa, I
Koishi, S
Yamamoto, K
Matsumoto, H
Hashimoto, O
Jinde, S
Nishida, H
Sugiyama, T
Kasai, K
Watanabe, K
Kano, Y
Kato, N
AF Marui, Tetsuya
Funatogawa, Ikuko
Koishi, Shinko
Yamamoto, Kenji
Matsumoto, Hideo
Hashimoto, Ohiko
Jinde, Seiichiro
Nishida, Hisami
Sugiyama, Toshiro
Kasai, Kiyoto
Watanabe, Keiichiro
Kano, Yukiko
Kato, Nobumasa
TI Association between autism and variants in the wingless-type MMTV
integration site family member 2 (WNT2) gene
SO INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
LA English
DT Article
DE Association study; autistic disorder; haplotype block; WNT2 gene
ID NO ASSOCIATION; SUSCEPTIBILITY; ABNORMALITIES; ETIOLOGY; DISORDER;
BRAIN; 7Q31
AB Autism is a severe neurodevelopmental disorder with a complex genetic aetiology. The wingless-type MMTV integration site family member 2 (WNT2) gene has been considered as a candidate gene for autism. We conducted a case-control study and followed up with a transmission disequilibrium test (TDT) analysis to confirm replication of the significant results for the first time. We conducted a case-control study of nine single nucleotide polymorphisms (SNPs) within the WNT2 gene in 170 patients with autism and 214 normal controls in a Japanese population. We then conducted a TOT analysis in 98 autistic families (trios) to replicate the results of the case-control study. In the case-control study, three SNPs (rs3779547, rs4727847 and rs3729629), two major individual haplotypes (A-T-C and G-G-G, consisting of rs3779547, rs4727847, and rs3729629), and global probability values of the haplotype distributions in the same region (global p=0.0091) showed significant associations with autism. Furthermore, all of these significant associations were also observed in the TOT analysis. Our findings provide evidence for a significant association between WNT2 and autism. Considering the important role of the WNT2 gene in brain development, our results therefore indicate that the WNT2 gene is one of the strong candidate genes for autism.
C1 [Marui, Tetsuya; Jinde, Seiichiro; Kasai, Kiyoto; Kato, Nobumasa] Univ Tokyo, Grad Sch Med, Dept Neuropsychiat, Tokyo 1130033, Japan.
[Marui, Tetsuya] Univ Tokyo, Grad Sch Frontier Sci, Dept Med Genome Sci, Tokyo 1130033, Japan.
[Funatogawa, Ikuko] Teikyo Univ, Sch Med, Dept Hyg & Publ Hlth, Tokyo 173, Japan.
[Koishi, Shinko; Sugiyama, Toshiro] Aichi Childrens Hlth & Med Ctr, Obu, Japan.
[Yamamoto, Kenji] Kitasato Univ, Sch Med, Dept Psychiat, Sagamihara, Kanagawa 228, Japan.
[Matsumoto, Hideo] Tokai Univ, Sch Med, Dept Psychiat, Isehara, Kanagawa 25911, Japan.
[Hashimoto, Ohiko] Aino Univ, Fac Nursing & Rehabil, Dept Occupat Therapy, Ibaraki, Japan.
[Nishida, Hisami] Asunaro Hosp Child & Adolescent Psychiat, Tsu, Mie, Japan.
[Watanabe, Keiichiro; Kano, Yukiko] Univ Tokyo, Sch Med, Dept Child Psychiat, Tokyo 1130033, Japan.
RP Marui, T (reprint author), Univ Tokyo, Sch Med, Dept Neuropsychiat, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1130033, Japan.
EM PXX03135@nifty.ne.jp
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NR 23
TC 13
Z9 14
PU CAMBRIDGE UNIV PRESS
PI NEW YORK
PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA
SN 1461-1457
J9 INT J NEUROPSYCHOPH
JI Int. J. Neuropsychopharmacol.
PD MAY
PY 2010
VL 13
IS 4
BP 443
EP 449
DI 10.1017/S1461145709990903
PG 7
WC Clinical Neurology; Neurosciences; Pharmacology & Pharmacy; Psychiatry
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA 604KU
UT WOS:000278278700004
PM 19895723
ER
PT J
AU Suzuki, K
Nishimura, K
Sugihara, G
Nakamura, K
Tsuchiya, KJ
Matsumoto, K
Takebayashi, K
Isoda, H
Sakahara, H
Sugiyama, T
Tsujii, M
Takei, N
Mori, N
AF Suzuki, Katsuaki
Nishimura, Katsuhiko
Sugihara, Genichi
Nakamura, Kazuhiko
Tsuchiya, Kenji J.
Matsumoto, Kaori
Takebayashi, Kiyokazu
Isoda, Haruo
Sakahara, Harumi
Sugiyama, Toshiro
Tsujii, Masatsugu
Takei, Nori
Mori, Norio
TI Metabolite alterations in the hippocampus of high-functioning adult
subjects with autism
SO INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
LA English
DT Article
DE Aggression; autism; hippocampus; magnetic resonance spectroscopy
ID AGGRESSION QUESTIONNAIRE; AMYGDALA; CHILDREN; BRAIN; DISORDER;
SPECTROSCOPY; CEREBELLUM; SPECTRUM; VERSION
AB The aim of the present study was to investigate metabolite alterations in the hippocarnpal formation as they relate to aggression in high-functioning adults with autism. We measured concentrations of N-acetylaspartate (NAA), choline-containing compounds (Cho), and creatine plus phosphocreatine (Cr + PCr) in the hippocampal formation by proton magnetic resonance spectroscopy in 12 non-medicated male subjects with autism and 12 age- and sex-matched controls. Aggression was scored in the autistic subjects using the Buss-Perry Aggression Questionnaire. The concentrations of Cho and Cr + PCr in the hippocampal formation in autistic subjects were significantly higher than the corresponding values in control subjects, and a significant positive correlation was observed between the concentrations of these metabolites in the hippocampal formation and scores on the Buss-Perry Aggression Questionnaire in autistic subjects. Results suggest that high-functioning adult subjects with autism have abnormal metabolite concentrations in the hippocampal formation, which may in part account for their aggression.
C1 [Suzuki, Katsuaki; Sugihara, Genichi; Tsuchiya, Kenji J.; Matsumoto, Kaori; Takei, Nori] Hamamatsu Univ Sch Med, Osaka Hamamatsu Joint Res Ctr Child Mental Dev, Higashi Ku, Hamamatsu, Shizuoka 4313192, Japan.
[Nishimura, Katsuhiko; Nakamura, Kazuhiko; Takebayashi, Kiyokazu; Mori, Norio] Hamamatsu Univ Sch Med, Dept Psychiat & Neurol, Hamamatsu, Shizuoka 4313192, Japan.
[Isoda, Haruo; Sakahara, Harumi] Hamamatsu Univ Sch Med, Dept Radiol, Hamamatsu, Shizuoka 4313192, Japan.
[Sugiyama, Toshiro] Aichi Childrens Hlth & Med Ctr, Obu, Japan.
[Tsujii, Masatsugu] Chukyo Univ, Fac Sociol, Toyota, Japan.
RP Suzuki, K (reprint author), Hamamatsu Univ Sch Med, Osaka Hamamatsu Joint Res Ctr Child Mental Dev, Higashi Ku, 1-20-1 Handayama, Hamamatsu, Shizuoka 4313192, Japan.
EM k-suzuki@hama-med.ac.jp
FU Ministry of Education, Culture, Sports, Science, and Technology of Japan
FX This work was supported by Grants-in-Aid for Scientific Research (B) and
(C) from the Ministry of Education, Culture, Sports, Science, and
Technology of Japan to Dr K. Nakamura and Dr G. Sugihara, respectively.
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NR 25
TC 8
Z9 8
PU CAMBRIDGE UNIV PRESS
PI NEW YORK
PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA
SN 1461-1457
J9 INT J NEUROPSYCHOPH
JI Int. J. Neuropsychopharmacol.
PD MAY
PY 2010
VL 13
IS 4
BP 529
EP 534
DI 10.1017/S1461145709990952
PG 6
WC Clinical Neurology; Neurosciences; Pharmacology & Pharmacy; Psychiatry
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA 604KU
UT WOS:000278278700012
PM 19895725
ER
PT J
AU Semrud-Clikeman, M
Walkowiak, J
Wilkinson, A
Minne, EP
AF Semrud-Clikeman, Margaret
Walkowiak, Jenifer
Wilkinson, Alison
Minne, Elizabeth Portman
TI Direct and Indirect Measures of Social Perception, Behavior, and
Emotional Functioning in Children with Asperger's Disorder, Nonverbal
Learning Disability, or ADHD
SO JOURNAL OF ABNORMAL CHILD PSYCHOLOGY
LA English
DT Article
DE Behavior; Social perception; Asperger's disorder; Nonverbal learning
disabilities; ADHD
ID PERVASIVE DEVELOPMENTAL DISORDER; DEFICIT HYPERACTIVITY DISORDER;
SYMPTOM SUBTYPES; AUTISM; VALIDATION
AB Understanding social interactions is crucial for development of social competence. The present study was one of the first to utilize direct and indirect measures of social perception to explore possible differences among children with nonverbal learning disability (NLD), Asperger's Syndrome (AS), Attention Deficit Hyperactivity Disorder-Combined (ADHD-C), Attention Deficit Hyperactivity Disorder-Predominately Inattentive (ADHD-PI), and controls (N = 342). Multiple informants provided ratings of the child's behavioral and social functioning. Results indicated that the NLD and AS groups experienced the most difficulty understanding emotional and nonverbal cues on the direct measure. In addition, children with AS or NLD showed significant signs of sadness and social withdrawal compared to the other groups. Attentional skills, while related to social perception, did not predict social perception difficulties to the same degree as number of AS symptoms.
C1 [Semrud-Clikeman, Margaret] Michigan State Univ, Dept Psychol, E Lansing, MI 48824 USA.
[Semrud-Clikeman, Margaret] Michigan State Univ, Dept Psychiat, E Lansing, MI 48824 USA.
[Walkowiak, Jenifer] Childrens Natl Med Ctr, Washington, DC 20010 USA.
[Wilkinson, Alison] Childrens Med Ctr, Dallas, TX 75235 USA.
[Minne, Elizabeth Portman] Austin State Hosp, Austin, TX USA.
RP Semrud-Clikeman, M (reprint author), Michigan State Univ, Dept Psychol, 321 A W Fee Hall, E Lansing, MI 48824 USA.
EM semrudcl@msu.edu
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NR 46
TC 18
Z9 18
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0091-0627
J9 J ABNORM CHILD PSYCH
JI J. Abnorm. Child Psychol.
PD MAY
PY 2010
VL 38
IS 4
BP 509
EP 519
DI 10.1007/s10802-009-9380-7
PG 11
WC Psychology, Clinical; Psychology, Developmental
SC Psychology
GA 577JS
UT WOS:000276219800007
PM 20084452
ER
PT J
AU Wong, VCN
Sun, JG
AF Wong, Virginia Chun-Nei
Sun, Jie-Guang
TI Randomized Controlled Trial of Acupuncture Versus Sham Acupuncture in
Autism Spectrum Disorder
SO JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE
LA English
DT Article
ID MEDICINE TONGUE ACUPUNCTURE; ALTERNATIVE MEDICINE; CEREBRAL-PALSY;
DROOLING PROBLEMS; DOUBLE-BLIND; CHILDREN; CHINESE; COMPLEMENTARY;
PLACEBO; PART
AB Objective: We aim to study the efficacy of acupuncture versus sham acupuncture in children with autism spectrum disorder.
Methods: A single-blind randomized control trial was conducted in 50 children. These children were randomly assigned to the treatment group with tongue acupuncture (40 sessions over 8 weeks) or the control group (sham tongue acupuncture to nonacupoints in the tongue).
Results: There was improvement in both the treatment and control groups in all assessed measures but more so in the treatment than in the control group: (1) eye-hand coordination, performance, and practical reasoning of Griffiths Mental Developmental Scale; (2) sensory-motor, social, affectual, language, and total score of Ritvo-Freeman Real Life Scale; (3) Comprehension Language age in the Reynell Language Developmental Scale; and (4) Total Score and Mental Age in Symbolic Play Test. The only statistically significant improvement in the treatment as compared to the control group was seen in self-care and cognition domains of the Functional Independence Measure for children.
Conclusions: We had demonstrated that a short course of acupuncture had efficacy in improving various developmental and behavioral aspects of children with autism. The long-term efficacy in functional gain needs to be further explored.
C1 [Wong, Virginia Chun-Nei] Univ Hong Kong, Div Child Neurol Dev Pediat Neurohabilitat, Dept Pediat & Adolescent Med, Fac Med, Hong Kong, Hong Kong, Peoples R China.
[Sun, Jie-Guang] Hong Kong Int Tongue Acupuncture Brain Disorder R, Hong Kong, Hong Kong, Peoples R China.
RP Wong, VCN (reprint author), Univ Hong Kong, Div Child Neurol Dev Pediat Neurohabilitat, Dept Pediat & Adolescent Med, Fac Med, Hong Kong, Hong Kong, Peoples R China.
EM vcnwong@hku.hk
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NR 55
TC 10
Z9 11
PU MARY ANN LIEBERT INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1075-5535
J9 J ALTERN COMPLEM MED
JI J. Altern. Complement Med.
PD MAY
PY 2010
VL 16
IS 5
BP 545
EP 553
DI 10.1089/acm.2007.0768
PG 9
WC Integrative & Complementary Medicine
SC Integrative & Complementary Medicine
GA 598AL
UT WOS:000277803900007
PM 20804366
ER
PT J
AU Bertoglio, K
James, SJ
Deprey, L
Brule, N
Hendren, RL
AF Bertoglio, Kiah
James, S. Jill
Deprey, Lesley
Brule, Norman
Hendren, Robert L.
TI Pilot Study of the Effect of Methyl B12 Treatment on Behavioral and
Biomarker Measures in Children with Autism
SO JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE
LA English
DT Article
ID HOMOCYSTEINE METABOLISM; OXIDATIVE STRESS; RATING-SCALE; DISORDERS;
VITAMIN-B12; POPULATION; INTERVIEW; COBALAMIN; VERSION; AGE
AB Objectives: The study objectives were to determine whether methyl B12 treatment improves behavioral measures in children with autism and whether improvement is associated with increased plasma concentrations of glutathione (GSH) and an increased redox ratio of reduced glutathione to oxidized glutathione (GSH/GSSG), both of which have been previously identified to be low in children with autism.
Design: This was a 12-week, double-blind, placebo-controlled, cross-over clinical trial of injectable methyl B12. Following this 12-week study, subjects were given the option of entering a 6-month open-label trial of methyl B12.
Settings/location: All procedures took place at the UC Davis M.I.N.D. Institute.
Subjects: Subjects were 3 to 8 years old with autism.
Interventions: All subjects received 6 weeks of placebo and 6 weeks of methyl B12 at a dose of 64.5 mcg/kg every three days administered subcutaneously into the buttocks.
Outcome measures: Blood for GSH analysis and behavioral assessments were obtained at baseline, week 6, and week 12.
Results: Thirty (30) subjects completed the 12-week, double-blind study and 22 subjects completed the 6-month extension study. No statistically significant mean differences in behavior tests or in glutathione status were identified between active and placebo groups. Nine (9) subjects (30%) demonstrated clinically significant improvement on the Clinical Global Impression Scale and at least two additional behavioral measures. More notably, these responders exhibited significantly increased plasma concentrations of GSH and GSH/GSSG.
Conclusions: Comparison of the overall means between groups suggests that methyl B12 is ineffective in treating behavioral symptoms of autism. However, detailed data analysis suggests that methyl B12 may alleviate symptoms of autism in a subgroup of children, possibly by reducing oxidative stress. An increase in glutathione redox status (GSH/GSSG) may provide a biomarker for treatment response to methyl B12. Additional research is needed to delineate a subgroup of potential responders and ascertain a biomarker for response to methyl B12.
C1 [Hendren, Robert L.] UCSF Dept Psychiat, San Francisco, CA 94143 USA.
[Bertoglio, Kiah] Univ Calif, Davis Med Ctr, Dept Psychiat & Behav Sci, Sacramento, CA USA.
[Bertoglio, Kiah; Deprey, Lesley; Brule, Norman] Univ Calif, Davis Med Ctr, MIND Inst, Sacramento, CA USA.
[James, S. Jill] Univ Arkansas Med Sci, Dept Pediat, Arkansas Childrens Hosp Res Inst, Autism Metab Genom Lab, Little Rock, AR 72205 USA.
RP Hendren, RL (reprint author), UCSF Dept Psychiat, 401 Parnassus Ave,Box ADM, San Francisco, CA 94143 USA.
EM Robert.Hendren@ucsf.edu
FU The Medical Investigation of Neurodevelopmental Disorders (M.I.N.D.)
Institute of the University of California, Davis Medical Center
FX The authors would like to thank and acknowledge The Medical
Investigation of Neurodevelopmental Disorders (M.I.N.D.) Institute of
the University of California, Davis Medical Center, for providing
funding for this study and to Deb Matsumoto for her assistance in
preparing the manuscript.
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NR 25
TC 12
Z9 12
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1075-5535
EI 1557-7708
J9 J ALTERN COMPLEM MED
JI J. Altern. Complement Med.
PD MAY
PY 2010
VL 16
IS 5
BP 555
EP 560
DI 10.1089/acm.2009.0177
PG 6
WC Integrative & Complementary Medicine
SC Integrative & Complementary Medicine
GA 598AL
UT WOS:000277803900008
PM 20804367
ER
PT J
AU Solish, A
Perry, A
Minnes, P
AF Solish, Abbie
Perry, Adrienne
Minnes, Patricia
TI Participation of Children with and without Disabilities in Social,
Recreational and Leisure Activities
SO JOURNAL OF APPLIED RESEARCH IN INTELLECTUAL DISABILITIES
LA English
DT Article
DE activity participation; children with autism spectrum disorder; children
with intellectual disability; friendship; social inclusion; typically
developing children
ID MENTAL-RETARDATION; DEVELOPMENTAL-DISABILITIES; FRIENDSHIP FORMATION;
PEER RELATIONSHIPS; YOUNG-CHILDREN; PATTERNS; ADULTS; SCHOOL;
INVOLVEMENT; STUDENTS
AB Background
One method of promoting children's friendship development is through activity participation with peers. However, children with disabilities seem to engage in fewer of these activities, and when they do participate often do so primarily with adults.
Materials and Methods
This study compared activity participation and friendship in typically developing (TD) children (n = 90), children with an autism spectrum disorder (ASD; n = 65), and children with an intellectual disability (n = 30) between the ages of 5 and 17 years. Parents completed a questionnaire about their child's participation in social, recreational and leisure activities.
Results
The TD children participated in significantly more social and recreational activities and had more friends than the children with disabilities. Notable differences emerged among groups in the percentage of activities the children participated in with peers, parents and/or other adults. Some significant differences were noted between the ASD and intellectual disability groups.
Conclusions
Research concerning activity participation should continue to take into account not only whether children are engaging in activities, but explore more precisely 'with whom' these activities are occurring.
C1 [Solish, Abbie; Perry, Adrienne] York Univ, Dept Psychol, Toronto, ON M3J 1P3, Canada.
[Minnes, Patricia] Queens Univ, Dept Psychol, Kingston, ON K7L 3N6, Canada.
RP Perry, A (reprint author), York Univ, Dept Psychol, Behav Sci Bldg,4700 Keele St, Toronto, ON M3J 1P3, Canada.
EM perry@yorku.ca
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NR 23
TC 45
Z9 45
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 1360-2322
J9 J APPL RES INTELLECT
JI J. Appl. Res. Intellect. Disabil.
PD MAY
PY 2010
VL 23
IS 3
BP 226
EP 236
DI 10.1111/j.1468-3148.2009.00525.x
PG 11
WC Psychology, Educational; Rehabilitation
SC Psychology; Rehabilitation
GA 584YX
UT WOS:000276791900003
ER
PT J
AU Ling, CYM
Mak, WWS
Cheng, JNS
AF Ling, Candy Y. M.
Mak, Winnie W. S.
Cheng, Janice N. S.
TI Attribution Model of Stigma towards Children with Autism in Hong Kong
SO JOURNAL OF APPLIED RESEARCH IN INTELLECTUAL DISABILITIES
LA English
DT Article
DE attribution; autism; special education; stigma
ID COGNITIVE-EMOTIONAL ANALYSIS; CHALLENGING BEHAVIOR; MENTAL-ILLNESS;
INTELLECTUAL DISABILITIES; CARE STAFF; LEARNING-DISABILITIES;
HELPING-BEHAVIOR; PEOPLE; RESPONSES; IMPACT
AB Background
Accounting for the effects of knowledge of and experience with autism, the relationships of cognitive attribution (perceived controllability), emotions (anger and sympathy), as well as helping and punitive behavioural intentions towards children with autism were examined. Based on the attribution model, mediating effects of anger and sympathy on cognitive attributions and behavioural intentions were tested.
Materials and Methods
123 frontline staff in educational settings completed a modified version of the Attribution Questionnaire after reading a hypothetical vignette and completing a quiz on autism.
Results
Knowledge and experience were only significantly related to punitive behavioural intention towards children with autism. Anger and sympathy mediated the effect between perceived controllability on both helping and punitive behavioural intentions.
Conclusions
The intentional responses towards children with autism were strongly related to their emotional reactions. Thus, in addition to educating frontline staff about autism, training them on emotion regulation is equally important in autism stigma reduction.
C1 [Ling, Candy Y. M.; Mak, Winnie W. S.; Cheng, Janice N. S.] Chinese Univ Hong Kong, Dept Psychol, Shatin, Hong Kong, Peoples R China.
RP Mak, WWS (reprint author), Chinese Univ Hong Kong, Dept Psychol, Shatin, Hong Kong, Peoples R China.
EM wwsmak@psy.cuhk.edu.hk
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NR 62
TC 7
Z9 7
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 1360-2322
J9 J APPL RES INTELLECT
JI J. Appl. Res. Intellect. Disabil.
PD MAY
PY 2010
VL 23
IS 3
BP 237
EP 249
DI 10.1111/j.1468-3148.2008.00456.x
PG 13
WC Psychology, Educational; Rehabilitation
SC Psychology; Rehabilitation
GA 584YX
UT WOS:000276791900004
ER
PT J
AU Janeslatt, G
Granlund, M
Kottorp, A
Almqvist, L
AF Janeslatt, Gunnel
Granlund, Mats
Kottorp, Anders
Almqvist, Lena
TI Patterns of Time Processing Ability in Children with and without
Developmental Disabilities
SO JOURNAL OF APPLIED RESEARCH IN INTELLECTUAL DISABILITIES
LA English
DT Article
DE child development; cluster analysis; time management; time orientation;
time perception
ID DEFICIT HYPERACTIVITY DISORDER; PERSON-ORIENTED APPROACH; AUTISTIC
DISORDER; SPINA-BIFIDA; SLEEP; PERCEPTION; ADULTS
AB Background
Children with developmental disabilities, e.g. intellectual disability or autism, are reported to have problems in time perception, time orientation or time management, i.e. in time-processing ability (TPA). The aim was to investigate whether the problems described are diagnosis specific or reflect differences in age or in level of TPA.
Methods
Using a cross-sectional design, this study investigated if there were different patterns of TPA in 5- to 10-year-old children with (n = 77) and without disabilities (n = 89). The results indicated that the patterns of TPA mainly follow the chronological age of children without disabilities, all clusters differing as regards levels of TPA. Daily time management (as estimated by the parents) and children's self-rated autonomy differed between clusters and was related to TPA.
Conclusions
The level of TPA seems to be a more valid overall base than the type of diagnosis for the planning of interventions in daily time management.
C1 [Janeslatt, Gunnel] Ctr Clin Res Dalarna, SE-79182 Falun, Sweden.
[Janeslatt, Gunnel; Kottorp, Anders] Karolinska Inst, Div Occupat Therapy, Dept NVS, Huddinge, Sweden.
[Granlund, Mats] Jonkoping Univ, Sch Hlth Sci, Jonkoping, Sweden.
[Janeslatt, Gunnel; Granlund, Mats; Almqvist, Lena] Malardalen Univ, Sch Hlth Care & Social Welf, Vasteras, Sweden.
RP Janeslatt, G (reprint author), Ctr Clin Res Dalarna, Nissers Vag 3, SE-79182 Falun, Sweden.
EM gunnel.janeslatt@ltdalarna.se
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World Health Organization (WHO), 2007, INT CLASS FUNCT DIS
NR 45
TC 6
Z9 6
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 1360-2322
J9 J APPL RES INTELLECT
JI J. Appl. Res. Intellect. Disabil.
PD MAY
PY 2010
VL 23
IS 3
BP 250
EP 262
DI 10.1111/j.1468-3148.2009.00528.x
PG 13
WC Psychology, Educational; Rehabilitation
SC Psychology; Rehabilitation
GA 584YX
UT WOS:000276791900005
ER
PT J
AU Manning, MM
Wainwright, LD
AF Manning, Margaret M.
Wainwright, Laurel D.
TI The Role of High Level Play as a Predictor Social Functioning in Autism
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism; Pretend play; Social functioning
ID MENTAL-RETARDATION; SYMBOLIC PLAY; PRETEND PLAY; CHILDREN; GENERATIVITY;
DEFICITS; LANGUAGE
AB Play and social abilities of a group of children diagnosed with high functioning autism were compared to a second group diagnosed with a variety of developmental language disorders (DLD). The children with autism engaged in fewer acts of high level play. The children with autism also had significantly lower social functioning than the DLD group early in the play session; however, these differences were no longer apparent by the end of the play session. In addition, a significant association existed between play and social functioning regardless of diagnosis. This suggests that play may act as a current indicator of social ability while providing an arena for social skills practice.
C1 [Manning, Margaret M.] Univ Massachusetts, Sch Med, EK Shriver Ctr, Waltham, MA 02452 USA.
[Manning, Margaret M.; Wainwright, Laurel D.] Univ Massachusetts, Dept Psychol, Boston, MA 02125 USA.
RP Manning, MM (reprint author), Univ Massachusetts, Sch Med, EK Shriver Ctr, 200 Trapelo Rd, Waltham, MA 02452 USA.
EM Margaret.manning@umassmed.edu
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NR 28
TC 9
Z9 10
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD MAY
PY 2010
VL 40
IS 5
BP 523
EP 533
DI 10.1007/s10803-009-0899-9
PG 11
WC Psychology, Developmental
SC Psychology
GA 584NM
UT WOS:000276759300001
PM 19921415
ER
PT J
AU Freeth, M
Chapman, P
Ropar, D
Mitchell, P
AF Freeth, M.
Chapman, P.
Ropar, D.
Mitchell, P.
TI Do Gaze Cues in Complex Scenes Capture and Direct the Attention of High
Functioning Adolescents with ASD? Evidence from Eye-tracking
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Eye-tracking; Autism; Social scenes; Gaze following; Time-course
analysis
ID FACE-LIKE STIMULI; SOCIAL ATTENTION; SPECTRUM DISORDERS;
ASPERGER-SYNDROME; JOINT ATTENTION; AUTISM; CHILDREN; PERCEPTION;
FIXATION; INFANTS
AB Visual fixation patterns whilst viewing complex photographic scenes containing one person were studied in 24 high-functioning adolescents with Autism Spectrum Disorders (ASD) and 24 matched typically developing adolescents. Over two different scene presentation durations both groups spent a large, strikingly similar proportion of their viewing time fixating the person's face. However, time-course analyses revealed differences between groups in priorities of attention to the region of the face containing the eyes. It was also noted that although individuals with ASD were rapidly cued by the gaze direction of the person in the scene, this was not followed by an immediate increase in total fixation duration at the location of gaze, which was the case for typically developing individuals.
C1 [Freeth, M.] Univ Sheffield, Dept Psychol, Western Bank, Sheffield S10 2TP, S Yorkshire, England.
[Freeth, M.; Chapman, P.; Ropar, D.; Mitchell, P.] Univ Nottingham, Sch Psychol, Nottingham NG7 2RD, England.
RP Freeth, M (reprint author), Univ Sheffield, Dept Psychol, Western Bank, Sheffield S10 2TP, S Yorkshire, England.
EM m.freeth@sheffield.ac.uk
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NR 38
TC 33
Z9 35
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD MAY
PY 2010
VL 40
IS 5
BP 534
EP 547
DI 10.1007/s10803-009-0893-2
PG 14
WC Psychology, Developmental
SC Psychology
GA 584NM
UT WOS:000276759300002
PM 19904597
ER
PT J
AU Mann, JR
McDermott, S
Bao, H
Hardin, J
Gregg, A
AF Mann, Joshua R.
McDermott, Suzanne
Bao, Haikun
Hardin, James
Gregg, Anthony
TI Pre-Eclampsia, Birth Weight, and Autism Spectrum Disorders
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism; Eclampsia; Pre-eclampsia; Birth weight; Epidemiology
ID PERVASIVE DEVELOPMENTAL DISORDERS; PERINATAL RISK-FACTORS; PRETERM
BIRTH; EPIDEMIOLOGY; POPULATION; DIAGNOSIS; BRAIN; AGE
AB Autism spectrum disorders (ASD) are primarily inherited, but perinatal or other environmental factors may also be important. In an analysis of 87,677 births from 1996 through 2002, insured by the South Carolina Medicaid program, birth weight was significantly inversely associated with the odds of ASD (OR = 0.78, p = .001 for each additional kilogram). Maternal pre-eclampsia/eclampsia was significantly associated with greater odds of ASD (OR = 1.85, p < .0001 without controlling for birth weight; OR = 1.69, p = .0005, when controlling for birth weight). We conclude that reduced birth weight partially mediates the association between pre-eclampsia/eclampsia and ASD. Additional research is needed to investigate the potential mechanism(s) by which pre-eclampsia/eclampsia may influence ASD risk.
C1 [Mann, Joshua R.; McDermott, Suzanne] Univ S Carolina, Sch Med, Dept Family & Prevent Med, Columbia, SC 29203 USA.
[Bao, Haikun; Hardin, James] Univ S Carolina, Arnold Sch Publ Hlth, Columbia, SC 29203 USA.
[Gregg, Anthony] Univ S Carolina, Sch Med, Dept Obstet & Gynecol, Columbia, SC 29203 USA.
RP Mann, JR (reprint author), Univ S Carolina, Sch Med, Dept Family & Prevent Med, Columbia, SC 29203 USA.
EM Joshua.mann@uscmed.sc.edu
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NR 33
TC 19
Z9 21
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD MAY
PY 2010
VL 40
IS 5
BP 548
EP 554
DI 10.1007/s10803-009-0903-4
PG 7
WC Psychology, Developmental
SC Psychology
GA 584NM
UT WOS:000276759300003
PM 19936906
ER
PT J
AU Warren, SF
Gilkerson, J
Richards, JA
Oller, DK
Xu, DX
Yapanel, U
Gray, S
AF Warren, Steven F.
Gilkerson, Jill
Richards, Jeffrey A.
Oller, D. Kimbrough
Xu, Dongxin
Yapanel, Umit
Gray, Sharmistha
TI What Automated Vocal Analysis Reveals About the Vocal Production and
Language Learning Environment of Young Children with Autism
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism; Language development; Assessment; Conversational turn-taking;
Language input; Automated vocal analysis
ID BEHAVIORS; SPEECH
AB The study compared the vocal production and language learning environments of 26 young children with autism spectrum disorder (ASD) to 78 typically developing children using measures derived from automated vocal analysis. A digital language processor and audio-processing algorithms measured the amount of adult words to children and the amount of vocalizations they produced during 12-h recording periods in their natural environments. The results indicated significant differences between typically developing children and children with ASD in the characteristics of conversations, the number of conversational turns, and in child vocalizations that correlated with parent measures of various child characteristics. Automated measurement of the language learning environment of young children with ASD reveals important differences from the environments experienced by typically developing children.
C1 [Warren, Steven F.] Univ Kansas, Inst Life Span Studies, Lawrence, KS 66045 USA.
[Gilkerson, Jill; Richards, Jeffrey A.; Xu, Dongxin; Yapanel, Umit; Gray, Sharmistha] LENA Fdn, Boulder, CO USA.
[Oller, D. Kimbrough] Univ Memphis, Memphis, TN 38152 USA.
RP Warren, SF (reprint author), Univ Kansas, Inst Life Span Studies, Lawrence, KS 66045 USA.
EM sfwarren@ku.edu
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NR 54
TC 25
Z9 25
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD MAY
PY 2010
VL 40
IS 5
BP 555
EP 569
DI 10.1007/s10803-009-0902-5
PG 15
WC Psychology, Developmental
SC Psychology
GA 584NM
UT WOS:000276759300004
PM 19936907
ER
PT J
AU Mesibov, GB
Shea, V
AF Mesibov, Gary B.
Shea, Victoria
TI The TEACCH Program in the Era of Evidence-Based Practice
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE TEACCH; Evidence-based
ID PHOTOGRAPHIC ACTIVITY SCHEDULES; AUTISTIC-CHILDREN; YOUNG-CHILDREN;
COMPREHENSIVE TREATMENTS; TEACHING-CHILDREN; SELF-STIMULATION; ADULTS;
INTERVENTION; BEHAVIORS; PARENTS
AB 'Evidence-based practice' as initially defined in medicine and adult psychotherapy had limited applicability to autism interventions, but recent elaborations of the concept by the American Psychological Association (Am Psychol 61: 271-285, 2006) and Kazdin (Am Psychol 63(1):146-159, 2008) have increased its relevance to our field. This article discusses the TEACCH program (of which the first author is director) as an example of an evidence-based practice in light of recent formulations of that concept.
C1 [Mesibov, Gary B.; Shea, Victoria] Univ N Carolina, Div TEACCH, Carolina Inst Dev Disabil, Chapel Hill, NC 27599 USA.
RP Shea, V (reprint author), Univ N Carolina, Div TEACCH, Carolina Inst Dev Disabil, CB 7180, Chapel Hill, NC 27599 USA.
EM victoria.shea@mindspring.com
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NR 89
TC 24
Z9 24
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD MAY
PY 2010
VL 40
IS 5
BP 570
EP 579
DI 10.1007/s10803-009-0901-6
PG 10
WC Psychology, Developmental
SC Psychology
GA 584NM
UT WOS:000276759300005
PM 19937103
ER
PT J
AU Anholt, GE
Cath, DC
van Oppen, P
Eikelenboom, M
Smit, JH
van Megen, H
van Balkom, AJLM
AF Anholt, Gideon E.
Cath, Danielle C.
van Oppen, Patricia
Eikelenboom, Merijn
Smit, Johannes H.
van Megen, Harold
van Balkom, Anton J. L. M.
TI Autism and ADHD Symptoms in Patients with OCD: Are They Associated with
Specific OC Symptom Dimensions or OC Symptom Severity?
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Obsessive-compulsive disorder; Attention deficit/hyperactivity disorder;
Autism
ID OBSESSIVE-COMPULSIVE DISORDER; DEFICIT-HYPERACTIVITY-DISORDER;
ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; PERVASIVE DEVELOPMENTAL
DISORDER; HIGH-FUNCTIONING AUTISM; SPECTRUM QUOTIENT AQ;
PSYCHIATRIC-DISORDERS; COGNITIVE CONFIDENCE; SUSTAINED ATTENTION;
YOUNG-PEOPLE
AB In obsessive-compulsive disorder (OCD), the relationship between autism spectrum disorders (ASD), attention-deficit/hyperactivity disorder (ADHD) symptom, and obsessive-compulsive (OC) symptom dimensions and severity has scarcely been studied. Therefore, 109 adult outpatients with primary OCD were compared to 87 healthy controls on OC, ADHD and ASD symptoms. OCD patients showed increased ADHD and autism symptom frequencies, OCD + ADHD patients reporting more autism symptoms (particularly attention switching and social skills problems) than OCD - ADHD patients. Attention switching problems were most significant predictors of OC symptom dimensions (except hoarding) and of symptom severity. Hoarding was not associated with elevated autism scale scores, but with inattention. In conclusion, attention switching problems may reflect both symptom overlap and a common etiological factor underlying ASD, ADHD and OCD.
C1 [Cath, Danielle C.] Altrecht Anxiety Outpatient Program, NL-3551 DC Utrecht, Netherlands.
[Anholt, Gideon E.; van Oppen, Patricia; Eikelenboom, Merijn; Smit, Johannes H.; van Balkom, Anton J. L. M.] Vrije Univ Amsterdam Med Ctr, Dept Psychiat, Amsterdam, Netherlands.
[Anholt, Gideon E.; van Oppen, Patricia; Eikelenboom, Merijn; Smit, Johannes H.; van Balkom, Anton J. L. M.] Vrije Univ Amsterdam Med Ctr, Inst Extramural Med, Amsterdam, Netherlands.
[Cath, Danielle C.; van Oppen, Patricia; van Balkom, Anton J. L. M.] GGZ inGeest, Outpatient Clin Anxiety Disorders, Amsterdam, Netherlands.
[Cath, Danielle C.] Utrecht Univ Altrecht, Dept Clin & Hlth Psychol, Anxiety Outpatient Program, Utrecht, Netherlands.
[van Megen, Harold] Meerkanten Psychiat Inst, Ermelo, Netherlands.
RP Cath, DC (reprint author), Altrecht Anxiety Outpatient Program, Mimosastr 2-4, NL-3551 DC Utrecht, Netherlands.
EM cath@xs4all.nl
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NR 63
TC 20
Z9 20
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD MAY
PY 2010
VL 40
IS 5
BP 580
EP 589
DI 10.1007/s10803-009-0922-1
PG 10
WC Psychology, Developmental
SC Psychology
GA 584NM
UT WOS:000276759300006
PM 20039111
ER
PT J
AU Ingersoll, B
AF Ingersoll, Brooke
TI Broader Autism Phenotype and Nonverbal Sensitivity: Evidence for an
Association in the General Population
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Broader autism phenotype; Nonverbal sensitivity
ID SPECTRUM QUOTIENT AQ; COGNITIVE PHENOTYPE; DIAGNOSTIC VALIDITY;
PERSONALITY-TRAITS; ASPERGER-SYNDROME; CENTRAL COHERENCE;
FAMILY-HISTORY; PARENTS; RECOGNITION; CHILDREN
AB This study examined the relationship between characteristics of the Broader Autism Phenotype (BAP) and nonverbal sensitivity, the ability to interpret nonverbal aspects of communication, in a non-clinical sample of college students. One hundred and two participants completed a self-report measure of the BAP, the Autism Spectrum Quotient (AQ), and two tests of nonverbal sensitivity, the Test of Nonverbal Cue Knowledge (TONCK), and the Diagnostic Analysis of Nonverbal Accuracy 2 (DANVA2). AQ score was correlated with TONCK performance and number of errors on the adult faces subtest of the DANVA2, but not adult paralanguage or postures. These findings suggest that characteristics of ASD in the general population are associated with differences in both explicit and implicit knowledge of nonverbal cues.
C1 Michigan State Univ, Dept Psychol, E Lansing, MI 48824 USA.
RP Ingersoll, B (reprint author), Michigan State Univ, Dept Psychol, 105B Psychol Bldg, E Lansing, MI 48824 USA.
EM ingers19@msu.edu
RI Ingersoll, Brooke/A-9117-2012
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NR 45
TC 11
Z9 11
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD MAY
PY 2010
VL 40
IS 5
BP 590
EP 598
DI 10.1007/s10803-009-0907-0
PG 9
WC Psychology, Developmental
SC Psychology
GA 584NM
UT WOS:000276759300007
PM 19936903
ER
PT J
AU Cohen, IL
Tsiouris, JA
Flory, MJ
Kim, SY
Freedland, R
Heaney, G
Pettinger, J
Brown, WT
AF Cohen, Ira L.
Tsiouris, John A.
Flory, Michael J.
Kim, Soh-Yule
Freedland, Robert
Heaney, Glenn
Pettinger, Jill
Brown, W. Ted
TI A Large Scale Study of the Psychometric Characteristics of the IBR
Modified Overt Aggression Scale: Findings and Evidence for Increased
Self-Destructive Behaviors in Adult Females with Autism Spectrum
Disorder
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Aggression; Self-injury; Prevalence; Psychometrics; Rating scales;
Autism; Females
ID INTELLECTUAL DISABILITY; CHALLENGING BEHAVIORS; PSYCHIATRIC-DISORDERS;
PHYSICAL AGGRESSION; PREVALENCE; CHILDREN; VIOLENCE; RISK
AB The psychometric characteristics of the IBR Modified Overt Aggression Scale were studied in over 2,000 people with Intellectual Disability (ID). Reliability ranged from good to excellent. Aggression toward others and objects was highest in the youngest adults, in those in the moderate to severe range of ID, and in those with an autism spectrum diagnosis. Self-injury was highest in those in the severe to profound range of ID and in those with autism, particularly the females. Females with autism were also more likely to make the most self-deprecating statements. Our data suggest that adult females with autism are a unique group and support the notion that mood and anxiety disorders play a role in self-destructive behaviors in this population.
C1 [Cohen, Ira L.; Kim, Soh-Yule] New York State Inst Basic Res Dev Disabil, Dept Psychol, Staten Isl, NY 10314 USA.
[Tsiouris, John A.; Heaney, Glenn] New York State Inst Basic Res Dev Disabil, George A Jervis Clin, Staten Isl, NY 10314 USA.
[Flory, Michael J.] New York State Inst Basic Res Dev Disabil, Res Design & Anal Serv, Staten Isl, NY 10314 USA.
[Freedland, Robert] New York State Inst Basic Res Dev Disabil, Ctr Dev Neurosci & Dev Disabil, Staten Isl, NY 10314 USA.
[Pettinger, Jill] OMRDD Bur Behav & Clin Solut, Albany, NY USA.
[Brown, W. Ted] New York State Inst Basic Res Dev Disabil, Dept Human Genet, Staten Isl, NY 10314 USA.
RP Cohen, IL (reprint author), New York State Inst Basic Res Dev Disabil, Dept Psychol, 1050 Forest Hill Rd, Staten Isl, NY 10314 USA.
EM ira.cohen@omr.state.ny.us
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NR 37
TC 18
Z9 18
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD MAY
PY 2010
VL 40
IS 5
BP 599
EP 609
DI 10.1007/s10803-009-0908-z
PG 11
WC Psychology, Developmental
SC Psychology
GA 584NM
UT WOS:000276759300008
PM 19941156
ER
PT J
AU Griffith, GM
Hastings, RP
Nash, S
Hill, C
AF Griffith, Gemma M.
Hastings, Richard P.
Nash, Susie
Hill, Christopher
TI Using Matched Groups to Explore Child Behavior Problems and Maternal
Well-Being in Children with Down Syndrome and Autism
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism; Down syndrome; Child behavior; Maternal outcomes; Matched groups
ID INTELLECTUAL DISABILITY; YOUNG-CHILDREN; DEVELOPMENTAL-DISABILITIES;
MENTAL-RETARDATION; SOCIOECONOMIC POSITION; SYNDROME SPECIFICITY;
PRESCHOOL-CHILDREN; FAMILY STRESS; MOTHERS; PARENTS
AB Mothers of children with Down syndrome, autism, and mixed etiology intellectual disabilities, matched on child age, gender, and communication skills (n = 19 in each group) completed measures of their child's adaptive and problem behaviors, their own parenting stress, and positive perceptions of their child. Children with autism were rated as having more problem behaviors and lower levels of social competence than children with Down syndrome and mixed etiology intellectual disabilities. Mothers of children with autism scored lower on positive perceptions of their child, and higher on stress than the other two groups. After selecting closely matched groups, we found several group differences in child behavior but little evidence of group differences in maternal outcomes.
C1 [Griffith, Gemma M.; Hastings, Richard P.; Nash, Susie; Hill, Christopher] Bangor Univ, Sch Psychol, Bangor LL57 2AS, Gwynedd, Wales.
RP Griffith, GM (reprint author), Bangor Univ, Sch Psychol, Brigantia Bldg,Penrhalt Rd, Bangor LL57 2AS, Gwynedd, Wales.
EM psp017@bangor.ac.uk
RI Hastings, Richard/D-9657-2013
OI Hastings, Richard/0000-0002-0495-8270
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NR 45
TC 32
Z9 33
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD MAY
PY 2010
VL 40
IS 5
BP 610
EP 619
DI 10.1007/s10803-009-0906-1
PG 10
WC Psychology, Developmental
SC Psychology
GA 584NM
UT WOS:000276759300009
PM 19936904
ER
PT J
AU Sawyer, MG
Bittman, M
La Greca, AM
Crettenden, AD
Harchak, TF
Martin, J
AF Sawyer, Michael G.
Bittman, Michael
La Greca, Annette M.
Crettenden, Angela D.
Harchak, Taylor F.
Martin, Jon
TI Time Demands of Caring for Children with Autism: What are the
Implications for Maternal Mental Health?
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism; Mothers; Caregiving time; Mental health problems; Time use
ID SOCIAL SUPPORT; DIFFICULTIES-QUESTIONNAIRE; SPECTRUM DISORDERS;
PRESCHOOL-CHILDREN; PSYCHOMETRIC PROPERTIES; BEHAVIOR PROBLEMS;
PARENTING STRESS; MOTHERS; IMPACT; STRENGTHS
AB This study examined the relationship between maternal mental health problems and both caregiving time and experience of time pressure for 216 mothers of children with autism. Data describing caregiving time was obtained using 24-h time-diaries. Standard questionnaires were used to assess time pressure, social support, children's emotional and behavioural problems, and maternal mental health problems. After adjusting for the effect of children's age, maternal social support, and children's behaviour problems, time pressure but not hours of caregiving, had a significant positive relationship with maternal mental health problems. Findings suggest that the quality of home-based care for children with autism may be adversely affected if time pressure experienced by caregivers compromises their mental health and well being.
C1 [Sawyer, Michael G.] Univ Adelaide, Dept Paediat, Adelaide, SA, Australia.
[Sawyer, Michael G.; Harchak, Taylor F.] Youth & Womens Hlth Serv, Res & Evaluat Unit, Adelaide, SA 5006, Australia.
[Bittman, Michael] Univ New England, Dept Sociol, Armidale, NSW, Australia.
[La Greca, Annette M.] Univ Miami, Dept Psychol, Coral Gables, FL 33124 USA.
[Crettenden, Angela D.] Univ S Australia, Australian Ctr Child Protect, Magill, SA, Australia.
[Martin, Jon] Autism SA, Marleston Dc, SA, Australia.
RP Sawyer, MG (reprint author), Univ Adelaide, Dept Paediat, Adelaide, SA, Australia.
EM michael.sawyer@adelaide.edu.au
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NR 58
TC 24
Z9 24
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD MAY
PY 2010
VL 40
IS 5
BP 620
EP 628
DI 10.1007/s10803-009-0912-3
PG 9
WC Psychology, Developmental
SC Psychology
GA 584NM
UT WOS:000276759300010
PM 19949845
ER
PT J
AU Yoder, PJ
Lieberman, RG
AF Yoder, Paul J.
Lieberman, Rebecca G.
TI Brief Report: Randomized Test of the Efficacy of Picture Exchange
Communication System on Highly Generalized Picture Exchanges in Children
with ASD
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism; Communication; PECS; Intervention; Generalization; Generality
ID AUTISM SPECTRUM DISORDERS; SPEECH DEVELOPMENT; PRESCHOOLERS; PECS
AB A randomized control trial comparing two social-communication interventions in young children with autism examined far-transfer of the use of picture exchange to communicate. Thirty-six children were randomly assigned to one of two treatment conditions, one of which was the Picture Exchange Communication System (PECS). All children had access to picture symbols during assessments. Post-treatment measurement of the number of picture exchanges in a far-transfer, assessment context favored the PECS intervention. These findings were interpreted as support for the hypothesis that the PECS curriculum can successfully teach a generalized means of showing coordinated attention to object and person without requiring eye contact to children with ASD.
C1 [Yoder, Paul J.; Lieberman, Rebecca G.] Vanderbilt Univ, Dept Special Educ, Nashville, TN 37203 USA.
RP Yoder, PJ (reprint author), Vanderbilt Univ, Dept Special Educ, Peabody Box 228, Nashville, TN 37203 USA.
EM rebecca.g.lieberman@vanderbilt.edu
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NR 16
TC 9
Z9 10
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD MAY
PY 2010
VL 40
IS 5
BP 629
EP 632
DI 10.1007/s10803-009-0897-y
PG 4
WC Psychology, Developmental
SC Psychology
GA 584NM
UT WOS:000276759300011
PM 19904596
ER
PT J
AU Hilton, CL
Fitzgerald, RT
Jackson, KM
Maxim, RA
Bosworth, CC
Shattuck, PT
Geschwind, DH
Constantino, JN
AF Hilton, Claudia L.
Fitzgerald, Robert T.
Jackson, Kelley M.
Maxim, Rolanda A.
Bosworth, Christopher C.
Shattuck, Paul T.
Geschwind, Daniel H.
Constantino, John N.
TI Brief Report: Under-Representation of African Americans in Autism
Genetic Research: A Rationale for Inclusion of Subjects Representing
Diverse Family Structures
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Ethnicity; African American; Minority representation
ID MINORITY RECRUITMENT; SPECTRUM DISORDER; MEDICAL-RESEARCH; RISK;
STRATEGIES; CHILDREN; DISEASE; PARTICIPATION; SCHIZOPHRENIA; ENROLLMENT
AB African American children with autism are seriously under-represented in existing genetic registries and biomedical research studies of autism. We estimated the number of African American children with autism in the St. Louis region using CDC surveillance data and present the outcomes of a concerted effort to enroll approximately one-third of that population into either of two large national genetic autism registries. The results revealed that even after traditional barriers to research participation were addressed and all contacted families expressed a willingness to participate, 67% of the reachable families were disqualified from participation because of family structure alone. Comprehensive efforts-including expansion of eligibility to families of diverse structure-are warranted to facilitate the inclusion of African American children in biomedical research.
C1 [Hilton, Claudia L.; Fitzgerald, Robert T.; Jackson, Kelley M.; Bosworth, Christopher C.; Constantino, John N.] Washington Univ, Sch Med, Dept Psychiat, St Louis, MO 63110 USA.
[Maxim, Rolanda A.] St Louis Univ, Knights Columbus Dev Ctr, St Louis, MO 63103 USA.
[Shattuck, Paul T.] Washington Univ, George Warren Brown Sch Social Work, St Louis, MO 63110 USA.
[Geschwind, Daniel H.] Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA 90095 USA.
RP Hilton, CL (reprint author), Washington Univ, Sch Med, Dept Psychiat, 660 S Euclid,Campus Box 8134, St Louis, MO 63110 USA.
EM hiltonc@wustl.edu
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*US DEP HHS, 2008, NAT CTR HLTH STAT VI
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NR 46
TC 8
Z9 8
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD MAY
PY 2010
VL 40
IS 5
BP 633
EP 639
DI 10.1007/s10803-009-0905-2
PG 7
WC Psychology, Developmental
SC Psychology
GA 584NM
UT WOS:000276759300012
PM 19936905
ER
PT J
AU Martin, JS
Poirier, M
Bowler, DM
AF Martin, Jonathan S.
Poirier, Marie
Bowler, Dermot M.
TI Brief Report: Impaired Temporal Reproduction Performance in Adults with
Autism Spectrum Disorder
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism; Asperger's syndrome; Time perception; Temporal reproduction
ID AGE-RELATED-CHANGES; TIME PERCEPTION; DURATION JUDGMENTS; MEMORY
PROCESSES; ATTENTION; CHILDREN; DEFICIT; CLOCK; YOUNG
AB Although temporal processing has received little attention in the autism literature, there are a number of reasons to suspect that people with autism spectrum disorder (ASD) may have particular difficulties judging the passage of time. The present study tested a group of 20 high-functioning adults with ASD and 20 matched comparison participants on a temporal reproduction task. The ASD group made reproductions that were significantly further from the base durations than did the comparison group. They were also more variable in their responses. Furthermore the ASD group showed particular difficulties as the base durations increased, tending to underestimate to a much greater degree than the comparison group. These findings support earlier evidence that temporal processing is impaired in ASD.
C1 [Martin, Jonathan S.] Univ Birmingham, Sch Psychol, Dept Clin Psychol, Birmingham B15 2TT, W Midlands, England.
[Martin, Jonathan S.; Poirier, Marie; Bowler, Dermot M.] City Univ London, Dept Psychol, London EC1V 0HB, England.
RP Martin, JS (reprint author), Univ Birmingham, Sch Psychol, Dept Clin Psychol, Birmingham B15 2TT, W Midlands, England.
EM jsm731@bham.ac.uk
CR American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th
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NR 33
TC 13
Z9 13
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD MAY
PY 2010
VL 40
IS 5
BP 640
EP 646
DI 10.1007/s10803-009-0904-3
PG 7
WC Psychology, Developmental
SC Psychology
GA 584NM
UT WOS:000276759300013
PM 19924521
ER
PT J
AU Blankenship, K
Erickson, C
AF Blankenship, Kelly
Erickson, Craig
TI Language and Autism: Applied Behavior Analysis, Evidence, and Practice
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Book Review
C1 [Blankenship, Kelly; Erickson, Craig] Indiana Univ, Sch Med, Dept Psychiat, Indianapolis, IN 46202 USA.
[Blankenship, Kelly; Erickson, Craig] James Whitcomb Riley Hosp Children, Christian Sakrine Autism Treatment Ctr, Indianapolis, IN 46202 USA.
RP Blankenship, K (reprint author), Indiana Univ, Sch Med, Dept Psychiat, Indianapolis, IN 46202 USA.
EM kellyrachal@yahoo.com
CR FITZER A, 2009, LANGUAGE AUTISM
NR 1
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD MAY
PY 2010
VL 40
IS 5
BP 647
EP 648
DI 10.1007/s10803-009-0833-1
PG 2
WC Psychology, Developmental
SC Psychology
GA 584NM
UT WOS:000276759300014
ER
PT J
AU Frye, RE
Butler, I
Strickland, D
Castillo, E
Papanicolaou, A
AF Frye, Richard E.
Butler, Ian
Strickland, David
Castillo, Edwardo
Papanicolaou, Andrew
TI Electroencephalogram Discharges in Atypical Cognitive Development
SO JOURNAL OF CHILD NEUROLOGY
LA English
DT Article
DE speech delay; attention deficit; pervasive developmental disorder;
electroencephalography; magnetoencephalography
ID EPILEPTIFORM EEG ABNORMALITIES; ELECTRICAL STATUS EPILEPTICUS; LANGUAGE
REGRESSION; PARTIAL EPILEPSY; CHILDREN; AUTISM; BENIGN; DISORDERS;
CHILDHOOD; SPECTRUM
AB To investigate the significance of electroencephalogram (EEG) discharges and their treatment, we retrospectively reviewed the charts of 22 children with atypical cognitive development that did not respond to standard educational therapy and demonstrated discharges on EEG. Most children demonstrated no obvious symptoms of seizures, and developmental regression and/or fluctuations were uncommon. The majority of children demonstrated a language and attention disorder and autism symptomatology and had multifocal discharges on EEGs. Of the 20 patients treated with antiepileptic medications, 70% demonstrated definite improvement within 1 clinic visit. This study suggests that children with EEG discharges and developmental cognitive disorders demonstrate a unique pattern of symptomatology and discharges on EEG. This study suggests that children with developmental cognitive disorders that do not respond to standard therapy may benefit from screening with an EEG and a trial of antiepileptic mediation if discharges are detected.
C1 [Frye, Richard E.; Butler, Ian] Univ Texas Hlth Sci Ctr Houston, Dept Pediat, Div Child & Adolescent Neurol, Houston, TX 77030 USA.
[Frye, Richard E.; Strickland, David; Castillo, Edwardo; Papanicolaou, Andrew] Univ Texas Hlth Sci Ctr Houston, Childrens Learning Inst, Dept Pediat, Houston, TX 77030 USA.
RP Frye, RE (reprint author), Univ Texas Hlth Sci Ctr Houston, Dept Pediat, Div Child & Adolescent Neurol, 7000 Fannin,UCT 2478, Houston, TX 77030 USA.
EM Richard.E.Frye@uth.tmc.edu
FU [NS046565]
FX The authors disclosed receipt of the following financial support for the
research and/or authorship of this article: NS046565 to Dr Richard E.
Frye, MD, PhD.
CR Ballaban-Gil K, 2000, MENT RETARD DEV D R, V6, P300, DOI 10.1002/1098-2779(2000)6:4<300::AID-MRDD9>3.0.CO;2-R
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NR 13
TC 6
Z9 6
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0883-0738
J9 J CHILD NEUROL
JI J. Child Neurol.
PD MAY
PY 2010
VL 25
IS 5
BP 556
EP 566
DI 10.1177/0883073809344743
PG 11
WC Clinical Neurology; Pediatrics
SC Neurosciences & Neurology; Pediatrics
GA 586YF
UT WOS:000276950800005
PM 20299700
ER
PT J
AU Meguid, N
Fahim, C
Yoon, U
Nashaat, NH
Ibrahim, AS
Mancini-Marie, A
Brandner, C
Evans, AC
AF Meguid, Nagwa
Fahim, Cherine
Yoon, Uicheul
Nashaat, Neveen H.
Ibrahim, Ahmed S.
Mancini-Marie, Adham
Brandner, Catherine
Evans, Alan C.
TI Brain Morphology in Autism and Fragile X Syndrome Correlates With Social
IQ: First Report From the Canadian-Swiss-Egyptian Neurodevelopmental
Study
SO JOURNAL OF CHILD NEUROLOGY
LA English
DT Article
DE autism; fragile X syndrome; magnetic resonance imaging; cerebral
cortical thickness; medial prefrontal; anterior cingulate
ID CEREBRAL-CORTEX; PSYCHIATRIC-DISORDERS; SPECTRUM DISORDER; CHILDHOOD
AUTISM; BEHAVIOR PROFILE; YOUNG-CHILDREN; MRI; BOYS; MATURATION; PROTEIN
AB Fragile X syndrome shares most of the behavioral phenotypic similarities with autism. How are these similarities reflected in brain morphology? A total of 10 children with autism and 7 with fragile X underwent morphological (T1) 1.5-T magnetic resonance imaging (MRI). The authors found no significant difference in total brain volumes, regional volumes, gyrification index, sulcul depth, and cerebral cortical thickness. However, children with autism showed significant decrease in the medial prefrontal bilaterally and the left anterior cingulate cortices. Regression analysis revealed positive correlation between the medial prefrontal cortical thickness and the social IQ. The authors suggest that the difference between the 2 groups in the medial prefrontal and anterior cingulate cortices thickness may entail an altered social cognitive style. Functional MRI studies directly differentiating between social indifference (autism) and social avoidance (fragile X) are needed to further characterize the spectrum of social abnormalities between these 2 groups.
C1 [Evans, Alan C.] McGill Univ, Montreal Neurol Inst, Dept Neurol & Neurosurg, McConnell Brain Imaging Ctr, Montreal, PQ H3A 2B4, Canada.
[Meguid, Nagwa; Nashaat, Neveen H.] Natl Res Ctr, Dept Children Special Needs, Div Med Genet, Cairo, Egypt.
[Ibrahim, Ahmed S.] Ain Shams Univ, Dept Radiol, Cairo, Egypt.
[Fahim, Cherine; Yoon, Uicheul; Evans, Alan C.] McGill Univ, Dept Neurol & Neurosurg, Fac Med, Montreal, PQ H3A 2B4, Canada.
[Fahim, Cherine; Brandner, Catherine] Univ Lausanne, Fac Social Sci & Polit, Lab Expt Study Behav LERB, Lausanne, Switzerland.
[Mancini-Marie, Adham] Univ Montreal, Fac Med, Ctr Rech Fernand Seguin, Montreal, PQ H3C 3J7, Canada.
[Mancini-Marie, Adham] Univ Geneva, Hop Univ Geneve HUG, Dept Psychiat, Geneva, Switzerland.
RP Evans, AC (reprint author), McGill Univ, Montreal Neurol Inst, Dept Neurol & Neurosurg, McConnell Brain Imaging Ctr, 3801 Univ St,Webster 2B, Montreal, PQ H3A 2B4, Canada.
EM alan.evans@mcgill.ca
FU Jeanne Timmins Costello Fellowship at the Montreal Neurological
Institute; University of Lausanne, Switzerland; Neuroinsight Foundation
for Brain Research Initiative in Egypt
FX We would like to thank the individuals and families who participated in
this study. NM is an expert in the genetics of childhood
neurodevelopmental disorders and the head of the department of children
with special needs at the National Research Centre in Egypt. CF is a
postdoctoral research associate of the Canadian Institutes of Health
Research, the Jeanne Timmins Costello Fellowship at the Montreal
Neurological Institute and the Michel Meany training award. We are
grateful to AE who offered the Egyptian Neuroimaging Neurodevelopmental
Genetics Initiative Network to use the Montreal Neurological Institute
facilities to analyze the current study data. This study is part of the
Canadian-Swiss-Egyptian Neurodevelopmental Study supported by the
University of Lausanne, Switzerland, and Neuroinsight Foundation for
Brain Research Initiative in Egypt. We deeply acknowledge the helpful
comments and suggestions of the Journal of Child Neurology anonymous
reviewers.
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NR 65
TC 10
Z9 12
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0883-0738
J9 J CHILD NEUROL
JI J. Child Neurol.
PD MAY
PY 2010
VL 25
IS 5
BP 599
EP 608
DI 10.1177/0883073809341670
PG 10
WC Clinical Neurology; Pediatrics
SC Neurosciences & Neurology; Pediatrics
GA 586YF
UT WOS:000276950800010
PM 20110214
ER
PT J
AU Gupta, S
Samra, D
Agrawal, S
AF Gupta, Sudhir
Samra, Daljeet
Agrawal, Sudhanshu
TI Adaptive and Innate Immune Responses in Autism: Rationale for
Therapeutic Use of Intravenous Immunoglobulin
SO JOURNAL OF CLINICAL IMMUNOLOGY
LA English
DT Article
DE Cytokines; chemokines; autoantibodies; dendritic cells; CVID; lymphocyte
subsets; IVIG; IgG; IgG subclasses
ID SPECTRUM DISORDERS; FETAL-BRAIN; CHILDREN; ANTIBODIES; CELLS; CHILDHOOD;
MOTHERS
AB Autism is a complex polygenic neurodevelopmental disorder characterized by deficits in communication and social interactions as well as specific stereotypical behaviors. Both genetic and environmental factors appear to contribute to the pathogenesis of autism. Accumulating data including changes in immune responses, linkage to major histocompatibility complex antigens, and the presence of autoantibodies to neural tissues/antigens suggest that the immune system plays an important role in its pathogenesis.
In this brief review, we discuss the data regarding changes in both innate and adaptive immunity in autism and the evidence in favor of the role of the immune system, especially of maternal autoantibodies in the pathogenesis of a subset of patients with autism. The rationale for possible therapeutic use of intravenous immunoglobulin is also discussed.
C1 [Gupta, Sudhir; Samra, Daljeet; Agrawal, Sudhanshu] Univ Calif Irvine, Div Basic & Clin Immunol, Irvine, CA 92697 USA.
RP Gupta, S (reprint author), Univ Calif Irvine, Div Basic & Clin Immunol, Med Sci 1,C-240, Irvine, CA 92697 USA.
EM sgupta@uci.edu
RI zhang, jing/F-3848-2012
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NR 29
TC 12
Z9 12
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0271-9142
J9 J CLIN IMMUNOL
JI J. Clin. Immunol.
PD MAY
PY 2010
VL 30
SU 1
BP S90
EP S96
DI 10.1007/s10875-010-9402-9
PG 7
WC Immunology
SC Immunology
GA 608YQ
UT WOS:000278622300018
ER
PT J
AU Valdovinos, MG
Bailey, L
Taylor, SL
AF Valdovinos, Maria G.
Bailey, Linda
Taylor, Steve L.
TI Examining Risperidone Use in Those Diagnosed With Autism 1 Year After
FDA Approval
SO JOURNAL OF CLINICAL PSYCHIATRY
LA English
DT Letter
ID CONTROLLED-TRIAL; CHILDREN; ADOLESCENTS; HALOPERIDOL; DISORDER; PLACEBO
C1 [Valdovinos, Maria G.] Drake Univ, Dept Psychol, Des Moines, IA 50311 USA.
[Taylor, Steve L.] Glenwood Resource Ctr, Glenwood, IA USA.
RP Valdovinos, MG (reprint author), Drake Univ, Dept Psychol, Des Moines, IA 50311 USA.
EM maria.valdovinos@drake.edu
RI Valdovinos, Maria/F-5721-2014
CR Akhondzadeh S, 2008, CHILD PSYCHIAT HUM D, V39, P237, DOI 10.1007/s10578-007-0084-3
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Hellings JA, 2006, J AUTISM DEV DISORD, V36, P401, DOI 10.1007/s10803-006-0078-1
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Tyrer P, 2008, LANCET, V371, P57, DOI 10.1016/S0140-6736(08)60072-0
NR 7
TC 0
Z9 0
PU PHYSICIANS POSTGRADUATE PRESS
PI MEMPHIS
PA P O BOX 240008, MEMPHIS, TN 38124 USA
SN 0160-6689
J9 J CLIN PSYCHIAT
JI J. Clin. Psychiatry
PD MAY
PY 2010
VL 71
IS 5
BP 651
EP 652
DI 10.4088/JCP.09l05665yel
PG 2
WC Psychology, Clinical; Psychiatry
SC Psychology; Psychiatry
GA 599XC
UT WOS:000277946400018
PM 20492856
ER
PT J
AU Levy, SE
Giarelli, E
Lee, LC
Schieve, LA
Kirby, RS
Cunniff, C
Nicholas, J
Reaven, J
Rice, CE
AF Levy, Susan E.
Giarelli, Ellen
Lee, Li-Ching
Schieve, Laura A.
Kirby, Russell S.
Cunniff, Christopher
Nicholas, Joyce
Reaven, Judy
Rice, Catherine E.
TI Autism Spectrum Disorder and Co-occurring Developmental, Psychiatric,
and Medical Conditions Among Children in Multiple Populations of the
United States
SO JOURNAL OF DEVELOPMENTAL AND BEHAVIORAL PEDIATRICS
LA English
DT Article
DE autism; autism spectrum; pervasive developmental disorder-not otherwise
specified; Asperger Syndrome; co-occurring diagnoses; medical disorders
ID DEFICIT HYPERACTIVITY DISORDER; HEALTH-CARE USE; ASPERGER-SYNDROME;
PRESCHOOL-CHILDREN; PREVALENCE; DISABILITIES; ATTENTION; SURVEILLANCE;
COMORBIDITY; DIAGNOSIS
AB Background: Autism spectrum disorders (ASDs) often co-occur with other developmental, psychiatric, neurologic, or medical diagnoses. Objective: This study examined co-occurring non-ASD diagnoses and symptoms in a population-based cohort of 8 year olds identified with ASD. Method: Data on 2,568 children meeting surveillance case definition for ASD were collected by a multi-site surveillance program. Information was systematically abstracted and reviewed from existing health and education source records and systematically entered into a summary record in a secure database. Results: Eighty-one percent of study children were male; 63% white, 23% black, 14% Hispanic, Asian, or not stated. When age of ASD classification was available, 20% were classified before age 3 years, 36% between ages 3 and 5 years, and 44% after age 5 years. The co-occurrence of >= 1 non-ASD developmental diagnoses was 83%, >= 1 psychiatric diagnoses was 10%, >= 1 neurologic diagnoses was 16%, and at least one possibly causative genetic or neurologic diagnosis was 4%. Children with a previous ASD classification and co-occurring psychiatric or neurologic conditions were more likely to be diagnosed or classified at a later age. Each category of co-occurring non-ASD diagnosis was significantly increased in children whose records did not include an ASD diagnosis or educational classification but who met surveillance criteria for ASD. Conclusions: These data highlight the need for clinicians to keep in mind the high prevalence of associated diagnoses with an ASD diagnosis, and the possibility that in younger children other symptoms or disorders may be masking or obscuring core symptoms of ASD, which would lead to a diagnosis.
C1 [Levy, Susan E.] Childrens Hosp Philadelphia, Reg Autism Ctr, Div Child Dev Rehabil & Metab Dis, Philadelphia, PA 19104 USA.
[Giarelli, Ellen] Univ Penn, Sch Nursing, Philadelphia, PA 19104 USA.
[Lee, Li-Ching] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Baltimore, MD USA.
[Schieve, Laura A.; Rice, Catherine E.] Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA USA.
[Kirby, Russell S.] Univ S Florida, Coll Publ Hlth, Dept Community & Family Hlth, Tampa, FL USA.
[Cunniff, Christopher] Univ Arizona, Coll Med, Dept Pediat, Tucson, AZ USA.
[Nicholas, Joyce] Med Univ S Carolina, Charleston, SC 29425 USA.
[Reaven, Judy] Univ Colorado, Sch Med, JFK Partners, Denver, CO USA.
RP Levy, SE (reprint author), Childrens Hosp Philadelphia, Reg Autism Ctr, Div Child Dev Rehabil & Metab Dis, Childrens Seashore House,3405 Civ Ctr Blvd, Philadelphia, PA 19104 USA.
EM levys@email.chop.edu
FU Centers for Disease Control and Prevention (CDC)
FX The data represented in this paper were collected by the Autism and
Developmental Disabilities Monitoring (ADDM) Network Surveillance Year
2002 supported by the Centers for Disease Control and Prevention (CDC).
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NR 30
TC 47
Z9 47
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0196-206X
EI 1536-7312
J9 J DEV BEHAV PEDIATR
JI J. Dev. Behav. Pediatr.
PD MAY
PY 2010
VL 31
IS 4
BP 267
EP 275
DI 10.1097/DBP.0b013e3181d5d03b
PG 9
WC Behavioral Sciences; Psychology, Developmental; Pediatrics
SC Behavioral Sciences; Psychology; Pediatrics
GA 597PE
UT WOS:000277769600001
PM 20431403
ER
PT J
AU Indredavik, MS
Vik, T
Evensen, KAI
Skranes, J
Taraldsen, G
Brubakk, AM
AF Indredavik, Marit S.
Vik, Torstein
Evensen, Kari Anne I.
Skranes, Jon
Taraldsen, Gunnar
Brubakk, Ann-Mari
TI Perinatal Risk and Psychiatric Outcome in Adolescents Born Preterm With
Very Low Birth Weight or Term Small for Gestational Age
SO JOURNAL OF DEVELOPMENTAL AND BEHAVIORAL PEDIATRICS
LA English
DT Article
DE mental health; behavior; very low birth weight; small for gestational
age; perinatal risk
ID ASPERGER-SYNDROME; CHILDREN; DISORDERS; ADULTHOOD; SYMPTOMS; GROWTH;
ABNORMALITIES; DEPRESSION; BEHAVIOR; AUTISM
AB Objective: To study perinatal risk factors for psychiatric symptoms in adolescents born preterm with very low birth weight or at term, but small for gestational age (GA). Method: Mental health was assessed in 65 adolescents born with very low birth weight (VLBW) (birth weight <= 1500 g), 59 born term small for GA (birth weight <10th centile) and 81 control adolescents using Schedule for Affective Disorders and Schizophrenia for School-Age Children, Children's Global Assessment Scale, Autism Spectrum Screening Questionnaire, Attention-Deficit Hyperactivity Disorder-Rating Scale IV and Achenbach System of Empirically Based Assessment. Perinatal data included birth weight, GA, head circumference, Apgar scores, intraventricular hemorrhage, days in neonatal intensive care unit, and days on mechanical ventilation. Results: In the very low birth weight group, lower birth weight was associated with inattention (p < .01), psychiatric diagnoses, and reduced psychosocial function (p <= .05). Intraventricular hemorrhage increased the risk for a high inattention score (odds ratio = 7.5; 95% confidence intervals: 1.2-46.8). Lower Apgar score at 1 min was associated with a high Autism Spectrum Screening Questionnaire score and lower Apgar score at 5 min with a high internalizing score (p <= .05). In the subgroup born appropriate for GA, internalizing symptoms were also associated with lower GA. In the term small for GA group, perinatal events were not associated with psychiatric problems. In contrast, low socioeconomic status was associated with externalizing symptoms. Conclusion: Lower birth weight, shorter gestation, and intraventricular hemorrhage were risk factors for psychiatric problems in the very low birth weight group. Lower Apgar score increased the risk for autism spectrum symptoms and internalizing symptoms. Among adolescents born term small for GA, the main risk factor for psychiatric symptoms was low socioeconomic status.
C1 [Indredavik, Marit S.] Norwegian Univ Sci & Technol, Dept Neurosci, Fac Med, NO-7489 Trondheim, Norway.
[Indredavik, Marit S.] St Olavs Univ Hosp, Dept Child & Adolescent Psychiat, Trondheim, Norway.
[Vik, Torstein; Evensen, Kari Anne I.; Skranes, Jon; Brubakk, Ann-Mari] Norwegian Univ Sci & Technol, Dept Lab Med, Childrens & Womens Hlth, NO-7489 Trondheim, Norway.
[Skranes, Jon; Brubakk, Ann-Mari] St Olavs Univ Hosp, Dept Pediat, Trondheim, Norway.
[Evensen, Kari Anne I.] St Olavs Univ Hosp, Dept Phys Med & Rehabil, Trondheim, Norway.
[Taraldsen, Gunnar] SINTEF Informat & Commun Technol, Trondheim, Norway.
RP Indredavik, MS (reprint author), Norwegian Univ Sci & Technol, Dept Neurosci, Fac Med, NO-7489 Trondheim, Norway.
EM marit.s.indredavik@ntnu.no
FU US National Institute of Child Health and Human Development, NIH (NICHD)
[1-HD-4-2803, 1-HD-1-3127]; Regional Centre for Child and Adolescent
Mental Health; Norwegian University of Science and Technology; St.
Olav's University Hospital
FX The investigation was funded by Regional Centre for Child and Adolescent
Mental Health, Norwegian University of Science and Technology, and
Research Funds at St. Olav's University Hospital.Part of the study
population was recruited from a multicenter study sponsored by the US
National Institute of Child Health and Human Development, NIH (NICHD
contract No. 1-HD-4-2803 and No. 1-HD-1-3127).
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NR 42
TC 30
Z9 30
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0196-206X
J9 J DEV BEHAV PEDIATR
JI J. Dev. Behav. Pediatr.
PD MAY
PY 2010
VL 31
IS 4
BP 286
EP 294
DI 10.1097/DBP.0b013e3181d7b1d3
PG 9
WC Behavioral Sciences; Psychology, Developmental; Pediatrics
SC Behavioral Sciences; Psychology; Pediatrics
GA 597PE
UT WOS:000277769600004
PM 20431402
ER
PT J
AU Stevens, L
Tartaglia, N
Hagerman, R
Riley, K
AF Stevens, Lindsay
Tartaglia, Nicole
Hagerman, Randi
Riley, Karen
TI Clinical Report A Male With Down Syndrome, Fragile X Syndrome, and
Autism
SO JOURNAL OF DEVELOPMENTAL AND BEHAVIORAL PEDIATRICS
LA English
DT Article
DE Down syndrome; fragile X syndrome; autism; intellectual disability
ID SPECTRUM DISORDER; STANDARDS
AB A case of a 14-year-old boy with both fragile X syndrome and Down syndrome is described. This is the third reported case of a patient with fragile X syndrome plus Down syndrome and the first reported case in a male. Facial features are generally consistent with Down syndrome; however, a prominent forehead and jaw and maccroorchidism were consistent with fragile X syndrome. Joint laxity is also present, which is consistent with both disorders. Cognitive impairment is more significant than in his siblings with fragile X syndrome, and he meets criteria for autistic disorder. Ongoing behavioral dysregulation has been significant, leading to disruption of home and school environments despite many attempted psychopharmacologic and behavioral strategies and a supportive family. Identification and treatment of underlying medical problems (esophagitis) led to improvements in sleep and behavior. We emphasize discussion of challenges in his behavioral management and present a collaborative approach to behavioral management.
C1 [Riley, Karen] Univ Denver, Morgridge Coll Educ, Denver, CO 80208 USA.
[Stevens, Lindsay] Lucile Packard Childrens Hosp Stanford, Palo Alto, CA USA.
[Tartaglia, Nicole] Univ Colorado Denver, Sch Med, Dept Pediat, Childrens Hosp,Child Dev Unit, Aurora, CO USA.
[Hagerman, Randi] Univ Calif Davis Hlth Syst, Dept Pediat, Sacramento, CA USA.
[Hagerman, Randi] Univ Calif Davis, MIND Inst, Sacramento, CA 95817 USA.
RP Riley, K (reprint author), Univ Denver, Morgridge Coll Educ, 2450 S Vine St, Denver, CO 80208 USA.
EM kriley@du.edu
FU NICHD [HD03671]; DHHS Administration for Children and Families
[90DD0596]; University of Colorado IDDRC; Rocky Mountain Down syndrome
Association
FX This work was partially supported by the following grants: NICHD grant
HD03671, DHHS Administration for Children and Families grant 90DD0596,
University of Colorado IDDRC, and a grant from the Rocky Mountain Down
syndrome Association.
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NR 23
TC 2
Z9 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0196-206X
J9 J DEV BEHAV PEDIATR
JI J. Dev. Behav. Pediatr.
PD MAY
PY 2010
VL 31
IS 4
BP 333
EP 337
DI 10.1097/DBP.0b013e3181d5aa56
PG 5
WC Behavioral Sciences; Psychology, Developmental; Pediatrics
SC Behavioral Sciences; Psychology; Pediatrics
GA 597PE
UT WOS:000277769600010
PM 20453578
ER
PT J
AU Farber, JM
AF Farber, Jon Matthew
TI Autism, Cognition, and Parent Counseling
SO JOURNAL OF DEVELOPMENTAL AND BEHAVIORAL PEDIATRICS
LA English
DT Article
AB Parents often have an inaccurate understanding of outcomes in autism, and developmentalists contribute to this when they omit consideration of cognitive functioning in their discussions with parents. Developmentalists need to incorporate information about cognitive levels (including intellectual disability, when present), in order to properly educate parents about prognosis for their child with autism.
RP Farber, JM (reprint author), 1990 Old Bridge Rd, Woodbridge, VA 22192 USA.
EM jmfpeds@msn.com
CR KANNER L, 1971, J AUTISM CHILD SCHIZ, V1, P119, DOI 10.1007/BF01537953
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NR 3
TC 1
Z9 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0196-206X
J9 J DEV BEHAV PEDIATR
JI J. Dev. Behav. Pediatr.
PD MAY
PY 2010
VL 31
IS 4
BP 341
EP 342
DI 10.1097/DBP.0b013e3181da779d
PG 2
WC Behavioral Sciences; Psychology, Developmental; Pediatrics
SC Behavioral Sciences; Psychology; Pediatrics
GA 597PE
UT WOS:000277769600012
PM 20453580
ER
PT J
AU Gupta, VB
AF Gupta, Vidya Bhushan
TI Communicating With Parents of Children With Autism About Vaccines and
Complementary and Alternative Approaches
SO JOURNAL OF DEVELOPMENTAL AND BEHAVIORAL PEDIATRICS
LA English
DT Article
ID RISK PERCEPTION; BAD-NEWS; IMMUNIZATION
AB Despite incontrovertible evidence that vaccines do not cause autism, some parents continue to refuse them and many parents of children with autism seek hope in unproven and potentially harmful complementary and alternative (CAM) approaches. This commentary explores the reasons for such behaviors and proposes that pediatricians may support parents in their pursuit of hope in unproven treatments as long as these are not potentially harmful to the child or prohibitively expensive. While respecting parental autonomy and hope the pediatricians should share with parents their concerns about lack of scientific evidence about CAM and potential for harm by some approaches.
C1 [Gupta, Vidya Bhushan] Metropolitan Hosp Ctr, Dept Pediat, New York, NY 10029 USA.
[Gupta, Vidya Bhushan] Morristown Mem & Overlook Hosp, Child Dev Ctr, Morristown, NJ USA.
RP Gupta, VB (reprint author), 12 Red Rock Trail, Saddle River, NJ 07458 USA.
EM bhushan458@gmail.com
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NR 14
TC 1
Z9 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0196-206X
J9 J DEV BEHAV PEDIATR
JI J. Dev. Behav. Pediatr.
PD MAY
PY 2010
VL 31
IS 4
BP 343
EP 345
DI 10.1097/DBP.0b013e3181d6b6e4
PG 3
WC Behavioral Sciences; Psychology, Developmental; Pediatrics
SC Behavioral Sciences; Psychology; Pediatrics
GA 597PE
UT WOS:000277769600014
PM 20453581
ER
PT J
AU Menghini, D
Addona, F
Costanzo, F
Vicari, S
AF Menghini, D.
Addona, F.
Costanzo, F.
Vicari, S.
TI Executive functions in individuals with Williams syndrome
SO JOURNAL OF INTELLECTUAL DISABILITY RESEARCH
LA English
DT Article
DE behavioural phenotypes; genetic syndrome; intellectual disability;
neuropsychological profile
ID FRAGILE-X-SYNDROME; WORKING-MEMORY; DOWN-SYNDROME; HYPERKINETIC
DISORDER; SPECTRUM DISORDERS; SHIFTING ATTENTION; DORSAL-STREAM;
CHILDREN; DEFICIT; AUTISM
AB Background
The present study was aimed at investigating working memory (WM) and executive functions capacities in individuals with Williams syndrome (WS) as compared with mental-age matched typically developing (TD) children.
Method
In order to serve the study goal, a sizeable battery of tasks tapping WM as well as attention, memory, planning, categorisation, shifting and inhibition abilities was administered to 15 individuals with WS (mean chronological age of 19.11 and mean mental age of 6.10), and to a group of 15 TD children (mean chronological age of 7.6 and mean mental age of 6.9).
Results
Participants with WS showed deficits in both verbal and visual-spatial modalities for selective and sustained attention, short-term memory and WM, planning and inhibition. However, considering categorisation and shifting abilities, relatively unimpaired performance emerged on those tasks relying on verbal materials.
Conclusions
These findings are both relevant to improve our knowledge about certain qualitative aspects of the anomalous cognitive development in WS as well as for its eventual clinical implications.
C1 [Vicari, S.] Childrens Hosp Bambino Gesu, Res Hosp, Dept Neurosci, Child Neuropsychiat Unit, I-00165 Rome, Italy.
[Menghini, D.] European Univ, Rome, Italy.
RP Vicari, S (reprint author), Childrens Hosp Bambino Gesu, Res Hosp, Dept Neurosci, Child Neuropsychiat Unit, I-00165 Rome, Italy.
EM vicari@opbg.net
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NR 77
TC 33
Z9 34
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0964-2633
J9 J INTELL DISABIL RES
JI J. Intell. Disabil. Res.
PD MAY
PY 2010
VL 54
BP 418
EP 432
DI 10.1111/j.1365-2788.2010.01287.x
PN 5
PG 15
WC Education, Special; Genetics & Heredity; Clinical Neurology; Psychiatry;
Rehabilitation
SC Education & Educational Research; Genetics & Heredity; Neurosciences &
Neurology; Psychiatry; Rehabilitation
GA 586SS
UT WOS:000276933900003
PM 20537048
ER
PT J
AU Bruno, DL
Anderlid, BM
Lindstrand, A
van Ravenswaaij-Arts, C
Ganesamoorthy, D
Lundin, J
Martin, CL
Douglas, J
Nowak, C
Adam, MP
Kooy, RF
Van der Aa, N
Reyniers, E
Vandeweyer, G
Stolte-Dijkstra, I
Dijkhuizen, T
Yeung, A
Delatycki, M
Borgstrom, B
Thelin, L
Cardoso, C
van Bon, B
Pfundt, R
de Vries, BBA
Wallin, A
Amor, DJ
James, PA
Slater, HR
Schoumans, J
AF Bruno, Damien L.
Anderlid, Britt-Marie
Lindstrand, Anna
van Ravenswaaij-Arts, Conny
Ganesamoorthy, Devika
Lundin, Johanna
Martin, Christa Lese
Douglas, Jessica
Nowak, Catherine
Adam, Margaret P.
Kooy, R. Frank
Van der Aa, Nathalie
Reyniers, Edwin
Vandeweyer, Geert
Stolte-Dijkstra, Irene
Dijkhuizen, Trijnie
Yeung, Alison
Delatycki, Martin
Borgstrom, Birgit
Thelin, Lena
Cardoso, Carlos
van Bon, Bregje
Pfundt, Rolph
de Vries, Bert B. A.
Wallin, Anders
Amor, David J.
James, Paul A.
Slater, Howard R.
Schoumans, Jacqueline
TI Further molecular and clinical delineation of co-locating 17p13.3
microdeletions and microduplications that show distinctive phenotypes
SO JOURNAL OF MEDICAL GENETICS
LA English
DT Article
ID MENTAL-RETARDATION; GENOMIC HYBRIDIZATION; NUMBER VARIATION;
DIEKER-SYNDROME; ALU REPEATS; REARRANGEMENTS; ARRAY; DELETIONS; IMPACT;
GENE
AB Background Chromosome 17p13.3 contains extensive repetitive sequences and is a recognised region of genomic instability. Haploinsufficiency of PAFAH1B1 (encoding LIS1) causes either isolated lissencephaly sequence or Miller-Dieker syndrome, depending on the size of the deletion. More recently, both microdeletions and microduplications mapping to the Miller-Dieker syndrome telomeric critical region have been identified and associated with distinct but overlapping phenotypes.
Methods Genome-wide microarray screening was performed on 7678 patients referred with unexplained learning difficulties and/or autism, with or without other congenital abnormalities. Eight and five unrelated individuals, respectively, were identified with microdeletions and microduplications in 17p13.3.
Results Comparisons with six previously reported microdeletion cases identified a 258 kb critical region, encompassing six genes including CRK (encoding Crk) and YWHAE (encoding 14-3-3 epsilon). Clinical features included growth retardation, facial dysmorphism and developmental delay. Notably, one individual with only subtle facial features and an interstitial deletion involving CRK but not YWHAE suggested that a genomic region spanning 109 kb, encompassing two genes (TUSC5 and YWHAE), is responsible for the main facial dysmorphism phenotype. Only the microduplication phenotype included autism. The microduplication minimal region of overlap for the new and previously reported cases spans 72 kb encompassing a single gene, YWHAE. These genomic rearrangements were not associated with low-copy repeats and are probably due to diverse molecular mechanisms.
Conclusions The authors further characterise the 17p13.3 microdeletion and microduplication phenotypic spectrum and describe a smaller critical genomic region allowing identification of candidate genes for the distinctive facial dysmorphism (microdeletions) and autism (microduplications) manifestations.
C1 [Bruno, Damien L.; Ganesamoorthy, Devika; Yeung, Alison; Delatycki, Martin; Amor, David J.; James, Paul A.; Slater, Howard R.] Murdoch Childrens Res Inst, Victorian Clin Genet Serv, Murdoch, WA, Australia.
[Bruno, Damien L.; Ganesamoorthy, Devika; Slater, Howard R.] Univ Melbourne, Royal Childrens Hosp, Dept Pediat, Melbourne, Vic, Australia.
[Anderlid, Britt-Marie; Lindstrand, Anna; Lundin, Johanna; Schoumans, Jacqueline] Karolinska Inst, Dept Mol Med & Surg, Clin Genet Unit, Stockholm, Sweden.
[van Ravenswaaij-Arts, Conny; Stolte-Dijkstra, Irene; Dijkhuizen, Trijnie] Univ Groningen, Dept Genet, Univ Med Ctr Groningen, Groningen, Netherlands.
[Martin, Christa Lese; Adam, Margaret P.] Emory Univ, Dept Human Genet, Atlanta, GA 30322 USA.
[Douglas, Jessica; Nowak, Catherine] Natl Birth Defects Ctr, Waltham, MA USA.
[Kooy, R. Frank; Van der Aa, Nathalie; Reyniers, Edwin; Vandeweyer, Geert] Univ Antwerp, B-2020 Antwerp, Belgium.
[Kooy, R. Frank; Van der Aa, Nathalie; Reyniers, Edwin; Vandeweyer, Geert] Univ Antwerp Hosp, Antwerp, Belgium.
[Borgstrom, Birgit] Karolinska Univ Hosp, Dept Endocrinol, Pediat Clin, Huddinge, Sweden.
[Thelin, Lena] Karolinska Inst, Sachs Childrens Hosp, Stockholm, Sweden.
[Cardoso, Carlos] Univ Aix Marseille 2, INSERM, INMED, U901, Marseille, France.
[van Bon, Bregje; Pfundt, Rolph; de Vries, Bert B. A.] Radboud Univ Nijmegen, Nijmegen Med Ctr, Dept Human Genet, NL-6525 ED Nijmegen, Netherlands.
[Wallin, Anders] Malar Hosp, Eskilstuna, Sweden.
RP Slater, HR (reprint author), Royal Childrens Hosp, Dept Cytogenet, VCGS Pathol, MCRI, Flemington Rd, Parkville, Vic 3052, Australia.
EM howard.slater@ghsv.org.au
RI Delatycki, Martin/A-5409-2013; van Bon, Bregje/D-3720-2013; Bruno,
Damien/C-3665-2013; Lindstrand, Anna/J-3566-2012; James,
Paul/G-2943-2014; Ganesamoorthy, Devika/J-8359-2014
OI Lindstrand, Anna/0000-0003-0806-5602; Ganesamoorthy,
Devika/0000-0001-8149-6703
FU Swedish Research Council; Karolinska Institute foundation; Stockholm
County Council; Perpetual Trustees Australia; EU; Netherlands
Organisation for Health Research and Development
FX We are grateful to all individuals and parents who participated in this
study. This work was supported by grants from The Swedish Research
Council (BMA), The Karolinska Institute foundation and Stockholm County
Council (to JS, BMA), Perpetual Trustees Australia (to HRS), and the
EU-funded AnEUploidy Project (to BBAdV and BvB) and the Netherlands
Organisation for Health Research and Development (to BBAdV). We also
thank Z Bowman, M Lagerberg, J Wincent and C Ngo for technical
assistance and J Senior for critically reading the manuscript.
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NR 36
TC 59
Z9 61
PU B M J PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 0022-2593
J9 J MED GENET
JI J. Med. Genet.
PD MAY
PY 2010
VL 47
IS 5
BP 299
EP 311
DI 10.1136/jmg.2009.069906
PG 13
WC Genetics & Heredity
SC Genetics & Heredity
GA 592FW
UT WOS:000277363500002
PM 20452996
ER
PT J
AU Shinawi, M
Liu, PF
Kang, SHL
Shen, J
Belmont, JW
Scott, DA
Probst, FJ
Craigen, WJ
Graham, BH
Pursley, A
Clark, G
Lee, J
Proud, M
Stocco, A
Rodriguez, DL
Kozel, BA
Sparagana, S
Roeder, ER
McGrew, SG
Kurczynski, TW
Allison, LJ
Amato, S
Savage, S
Patel, A
Stankiewicz, P
Beaudet, AL
Cheung, SW
Lupski, JR
AF Shinawi, Marwan
Liu, Pengfei
Kang, Sung-Hae L.
Shen, Joseph
Belmont, John W.
Scott, Daryl A.
Probst, Frank J.
Craigen, William J.
Graham, Brett H.
Pursley, Amber
Clark, Gary
Lee, Jennifer
Proud, Monica
Stocco, Amber
Rodriguez, Diana L.
Kozel, Beth A.
Sparagana, Steven
Roeder, Elizabeth R.
McGrew, Susan G.
Kurczynski, Thaddeus W.
Allison, Leslie J.
Amato, Stephen
Savage, Sarah
Patel, Ankita
Stankiewicz, Pawel
Beaudet, Arthur L.
Cheung, Sau Wai
Lupski, James R.
TI Recurrent reciprocal 16p11.2 rearrangements associated with global
developmental delay, behavioural problems, dysmorphism, epilepsy, and
abnormal head size
SO JOURNAL OF MEDICAL GENETICS
LA English
DT Article
ID 17Q21.31 MICRODELETION SYNDROME; GENOMIC DISORDERS; MENTAL-RETARDATION;
INCREASE RISK; AUTISM; DELETIONS; PROTEIN; BRAIN; SCHIZOPHRENIA;
EXPRESSION
AB Background Deletion and the reciprocal duplication in 16p11.2 were recently associated with autism and developmental delay.
Method We indentified 27 deletions and 18 duplications of 16p11.2 were identified in 0.6% of all samples submitted for clinical array-CGH (comparative genomic hybridisation) analysis. Detailed molecular and phenotypic characterisations were performed on 17 deletion subjects and ten subjects with the duplication.
Results The most common clinical manifestations in 17 deletion and 10 duplication subjects were speech/language delay and cognitive impairment. Other phenotypes in the deletion patients included motor delay (50%), seizures (similar to 40%), behavioural problems (similar to 40%), congenital anomalies (similar to 30%), and autism (similar to 20%). The phenotypes among duplication patients included motor delay (6/10), behavioural problems (especially attention deficit hyperactivity disorder (ADHD)) (6/10), congenital anomalies (5/10), and seizures (3/10). Patients with the 16p11.2 deletion had statistically significant macrocephaly (p<0.0017) and 6 of the 10 patients with the duplication had microcephaly. One subject with the deletion was asymptomatic and another with the duplication had a normal cognitive and behavioural phenotype. Genomic analyses revealed additional complexity to the 16p11.2 region with mechanistic implications. The chromosomal rearrangement was de novo in all but 2 of the 10 deletion cases in which parental studies were available. Additionally, 2 de novo cases were apparently mosaic for the deletion in the analysed blood sample. Three de novo and 2 inherited cases were observed in the 5 of 10 duplication patients where data were available.
Conclusions Recurrent reciprocal 16p11.2 deletion and duplication are characterised by a spectrum of primarily neurocognitive phenotypes that are subject to incomplete penetrance and variable expressivity. The autism and macrocephaly observed with deletion and ADHD and microcephaly seen in duplication patients support a diametric model of autism spectrum and psychotic spectrum behavioural phenotypes in genomic sister disorders.
C1 [Shinawi, Marwan; Liu, Pengfei; Kang, Sung-Hae L.; Belmont, John W.; Scott, Daryl A.; Probst, Frank J.; Craigen, William J.; Graham, Brett H.; Patel, Ankita; Stankiewicz, Pawel; Beaudet, Arthur L.; Cheung, Sau Wai; Lupski, James R.] Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA.
[Clark, Gary; Lee, Jennifer; Proud, Monica; Stocco, Amber; Rodriguez, Diana L.] Texas Childrens Hosp, Dept Pediat, Neurol Sect, Houston, TX 77030 USA.
[Shen, Joseph] Childrens Hosp Cent Calif, Madera, CA USA.
[Kozel, Beth A.] Washington Univ, Sch Med, Div Genet & Genom Med, St Louis, MO USA.
[Sparagana, Steven] Texas Scottish Rite Hosp Children, Dept Neurol, Dallas, TX 75219 USA.
[Sparagana, Steven] Univ Texas SW Med Ctr Dallas, Dallas, TX 75390 USA.
[Roeder, Elizabeth R.] Univ Texas Hlth Sci Ctr San Antonio, Dept Pediat, Div Genet & Metab Disorders, San Antonio, TX 78229 USA.
[McGrew, Susan G.] Vanderbilt Univ, Sch Med, Dept Pediat, Monroe Carell Jr Childrens Hosp Vanderbilt, Nashville, TN 37212 USA.
[Kurczynski, Thaddeus W.] Akron Childrens Hosp, Dept Pediat, Akron, OH USA.
[Allison, Leslie J.] Monarch Med Clin, Katy, TX USA.
[Amato, Stephen; Savage, Sarah] Eastern Maine Med Ctr, Dept Med Genet, Bangor, ME USA.
[Stankiewicz, Pawel] Inst Mother & Child Hlth, Dept Med Genet, Warsaw, Poland.
[Lupski, James R.] Baylor Coll Med, Dept Pediat, Houston, TX 77030 USA.
RP Cheung, SW (reprint author), Baylor Coll Med, Dept Mol & Human Genet, 1 Baylor Plaza,NAB 2015, Houston, TX 77030 USA.
EM scheung@bcm.tmc.edu
FU Polish Ministry of Science and Higher Education [R13-0005-04/2008];
National Institute of Neurological Disorders and Stroke, N. I. H. [RO1
NS058529]
FX The authors thank the patients and parents for their willingness to
participate in our research study. We thank Dr Feng Zhang for assistance
in the design of the high-resolution 16p11.2 specific array. P. S. was
supported in part by grant R13-0005-04/2008 from the Polish Ministry of
Science and Higher Education. This work was supported in part by
National Institute of Neurological Disorders and Stroke, N. I. H. grant
RO1 NS058529 to J.R.L.
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NR 48
TC 151
Z9 153
PU B M J PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 0022-2593
J9 J MED GENET
JI J. Med. Genet.
PD MAY
PY 2010
VL 47
IS 5
BP 332
EP 341
DI 10.1136/jmg.2009.073015
PG 10
WC Genetics & Heredity
SC Genetics & Heredity
GA 592FW
UT WOS:000277363500005
PM 19914906
ER
PT J
AU Orr, AG
Sharma, A
Binder, NB
Miller, AH
Pearce, BD
AF Orr, Anna G.
Sharma, Anup
Binder, Nikolaus B.
Miller, Andrew H.
Pearce, Bradley D.
TI Interleukin-1 Mediates Long-Term Hippocampal Dentate Granule Cell Loss
Following Postnatal Viral Infection
SO JOURNAL OF MOLECULAR NEUROSCIENCE
LA English
DT Article
DE Hippocampus; Autism; Schizophrenia; Lymphocytic choriomeningitis virus;
Neurodevelopment; Neuroprotection
ID LYMPHOCYTIC CHORIOMENINGITIS VIRUS; CENTRAL-NERVOUS-SYSTEM; RECEPTOR
ANTAGONIST; CYTOKINE EXPRESSION; ADULT NEUROGENESIS; NEONATAL INFECTION;
NEURONAL INJURY; RAT HIPPOCAMPUS; PERINATAL RATS; BRAIN-INJURY
AB Viral infections of the developing CNS can cause long-term neuropathological sequela through undefined mechanisms. Proinflammatory cytokines such as IL-1 beta have gained attention in mediating neurodegeneration in corticohippocampal structures due to a variety of insults in adults, though there is less information on the developing brain. Little is known concerning the spatial-temporal pattern of IL-1 beta induction in the developing hippocampus following live virus infection, and there are few studies addressing the long-term consequences of this cytokine induction. We report that infection of rats with lymphocytic choriomeningitis virus on postnatal day 4 induces IL-1 beta protein in select regions of the hippocampus on 6, 15, 21, and 45 days after infection. This infection resulted in a 71% reduction of dentate granule cell neurons by the time the rats reached mid-adulthood. We further investigated the causative role of IL-1 in this dentate granule cell loss by blocking IL-1 activity using an IL-1ra-expressing adenoviral vector administered at the time of infection. Blockade of IL-1 abrogated the infection-associated neuron loss in this vivo model. Considering that IL-1 can be triggered by multiple perinatal insults, our findings suggest that early therapy with anti-inflammatory agents that block IL-1 may be effective for reducing adulthood neuropathology.
C1 [Pearce, Bradley D.] Emory Univ, Dept Epidemiol, Atlanta, GA 30322 USA.
[Pearce, Bradley D.] Emory Univ, Grad Div Biol & Biomed Sci, Atlanta, GA 30322 USA.
[Orr, Anna G.; Sharma, Anup; Binder, Nikolaus B.; Miller, Andrew H.] Emory Univ, Dept Psychiat, Atlanta, GA 30322 USA.
RP Pearce, BD (reprint author), Emory Univ, Dept Epidemiol, Atlanta, GA 30322 USA.
EM bpearce@emory.edu
FU NIMH [5R29NS037068]; Theodore and Vada Stanley Foundation
FX This work was supported by NIMH grant 5R29NS037068 (to B. D. P.) and the
Theodore and Vada Stanley Foundation. We are grateful to Dr. Nancy
Bliwise (Emory University Department of Psychology) for her advice on
statistical analysis. We thank the University of Iowa Gene Vector Core
and Dr. Beverly Davidson for supplying the adenovirus vectors.
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NR 47
TC 2
Z9 2
PU HUMANA PRESS INC
PI TOTOWA
PA 999 RIVERVIEW DRIVE SUITE 208, TOTOWA, NJ 07512 USA
SN 0895-8696
J9 J MOL NEUROSCI
JI J. Mol. Neurosci.
PD MAY
PY 2010
VL 41
IS 1
BP 89
EP 96
DI 10.1007/s12031-009-9293-5
PG 8
WC Biochemistry & Molecular Biology; Neurosciences
SC Biochemistry & Molecular Biology; Neurosciences & Neurology
GA 573IH
UT WOS:000275905400012
PM 19774496
ER
PT J
AU Higashida, H
Lopatina, O
Yoshihara, T
Pichugina, YA
Soumarokov, AA
Munesue, T
Minabe, Y
Kikuchi, M
Ono, Y
Korshunova, N
Salmina, AB
AF Higashida, H.
Lopatina, O.
Yoshihara, T.
Pichugina, Y. A.
Soumarokov, A. A.
Munesue, T.
Minabe, Y.
Kikuchi, M.
Ono, Y.
Korshunova, N.
Salmina, A. B.
TI Oxytocin Signal and Social Behaviour: Comparison among Adult and Infant
Oxytocin, Oxytocin Receptor and CD38 Gene Knockout Mice
SO JOURNAL OF NEUROENDOCRINOLOGY
LA English
DT Review
DE oxytocin; oxytocin receptor; social recognition; maternal nurturing;
CD38; ADP-ribosyl cyclase; autism
ID CYCLIC ADP-RIBOSE; MATERNAL-BEHAVIOR; BRAIN; VASOPRESSIN; HUMANS;
AUTISM; MOUSE; SYSTEM; CONSEQUENCES; VOCALIZATION
AB Oxytocin in the hypothalamus is the biological basis of social recognition, trust, love and bonding. Previously, we showed that CD38, a proliferation marker in leukaemia cells, plays an important role in the hypothalamus in the process of oxytocin release in adult mice. Disruption of Cd38 (Cd38 -/-) elicited impairment of maternal behaviour and male social recognition in adult mice, similar to the behaviour observed in Oxt and oxytocin receptor (Oxtr) gene knockout (Oxt -/- and Oxtr -/-, respectively) mice. Locomotor activity induced by separation from the dam was higher and the number of ultrasonic vocalisation calls was lower in Cd38 -/- than Cd38 +/+ pups. However, these behavioural changes were much milder than those observed in Oxt -/- and Oxtr -/- mice, indicating less impairment of social behaviour in Cd38 -/- pups. These phenotypes appeared to be caused by the high plasma oxytocin levels during development from the neonatal period to 3-week-old juvenile mice. ADP-ribosyl cyclase activity was markedly lower in the knockout mice from birth, suggesting that weaning for mice is a critical time window of plasma oxytocin differentiation. Breastfeeding was an important exogenous source of plasma oxytocin regulation before weaning as a result of the presence of oxytocin in milk and the dam's mammary glands. The dissimilarity between Cd38 -/- infant behaviour and those of Oxt -/- or Oxtr -/- mice can be explained partly by this exogenous source of oxytocin. These results suggest that secretion of oxytocin into the brain in a CD38-dependent manner may play an important role in the development of social behaviour.
C1 [Higashida, H.; Lopatina, O.; Pichugina, Y. A.; Korshunova, N.] Kanazawa Univ, Grad Sch Med, Dept Biophys Genet, Kanazawa, Ishikawa 9208640, Japan.
[Higashida, H.; Yoshihara, T.; Munesue, T.; Minabe, Y.] Kanazawa Univ, Res Ctr Child Mental Dev, Kanazawa, Ishikawa 9208640, Japan.
[Higashida, H.; Lopatina, O.] Core Res Evolut Sci & Technol, Tokyo, Japan.
[Lopatina, O.; Salmina, A. B.] Krasnoyarsk State Med Univ, Dept Biochem Med Pharmaceut & Toxicol Chem, Krasnoyarsk, Russia.
[Pichugina, Y. A.; Soumarokov, A. A.] Krasnoyarsk State Med Univ, Dept Psychiat, Krasnoyarsk, Russia.
[Munesue, T.; Minabe, Y.; Kikuchi, M.; Ono, Y.] Kanazawa Univ, Grad Sch Med, Dept Psychaitry & Neurobiol, Kanazawa, Ishikawa 9208640, Japan.
RP Higashida, H (reprint author), Kanazawa Univ, Grad Sch Med, Dept Biophys Genet, 13-1 Takara Machi, Kanazawa, Ishikawa 9208640, Japan.
EM haruhiro@med.kanazawa-u.ac.jp
RI Salmina, Alla/L-7977-2013; Lopatina, Olga/I-9610-2014
FU Russian Foundation for Basic Research [08-04-91209]; Russian Foundation
for Basic Research and the Japan Society for the Promotion of Science
(RFBR-JSPS) [08-04-91209]
FX This work was supported by the bilateral grant 08-04-91209 from the
Russian Foundation for Basic Research and the Japan Society for the
Promotion of Science (RFBR-JSPS) (A.B.S., H.H.).
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NR 50
TC 33
Z9 33
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0953-8194
J9 J NEUROENDOCRINOL
JI J. Neuroendocrinol.
PD MAY
PY 2010
VL 22
IS 5
BP 373
EP 379
DI 10.1111/j.1365-2826.2010.01976.x
PG 7
WC Endocrinology & Metabolism; Neurosciences
SC Endocrinology & Metabolism; Neurosciences & Neurology
GA 585WW
UT WOS:000276862100007
PM 20141571
ER
PT J
AU Salmina, AB
Lopatina, O
Ekimova, MV
Mikhutkina, SV
Higashida, H
AF Salmina, A. B.
Lopatina, O.
Ekimova, M. V.
Mikhutkina, S. V.
Higashida, H.
TI CD38/Cyclic ADP-ribose System: A New Player for Oxytocin Secretion and
Regulation of Social Behaviour
SO JOURNAL OF NEUROENDOCRINOLOGY
LA English
DT Review
DE oxytocin; CD38; cyclic ADP-ribose; autism; social behaviour
ID RAT SUPRAOPTIC NEURONS; METABOTROPIC GLUTAMATE RECEPTORS; DENDRITIC
PEPTIDE RELEASE; CENTRAL-NERVOUS-SYSTEM; MAGNOCELLULAR NEURONS;
HYPOTHALAMONEUROHYPOPHYSEAL SYSTEM; NEUROSECRETORY-SYSTEM; INTRACELLULAR
CALCIUM; ADENINE-DINUCLEOTIDE; THERAPEUTIC TARGET
AB Oxytocin is important for regulating a number of physiological processes. Disruption of the secretion, metabolism or action of oxytocin results in an impairment of reproductive function, social and sexual behaviours, and stress responses. This review discusses current views on the regulation and autoregulation of oxytocin release in the hypothalamic-neurohypophysial system, with special focus on the activity of the CD38/cADP-ribose system as a new component in this regulation. Data from our laboratories indicate that an impairment of this system results in alterations of oxytocin secretion and abnormal social behaviour, thus suggesting new clues that help in our understanding of the pathogenesis of neurodevelopmental disorders.
C1 [Salmina, A. B.; Ekimova, M. V.; Mikhutkina, S. V.] Krasnoyarsk State Med Univ, Dept Biochem Med Pharmaceut & Toxicol Chem, Krasnoyarsk 660022, Russia.
[Lopatina, O.; Higashida, H.] Kanazawa Univ, Grad Sch Med, Dept Biophys Genet, Kanazawa, Ishikawa, Japan.
RP Salmina, AB (reprint author), Krasnoyarsk State Med Univ, Dept Biochem Med Pharmaceut & Toxicol Chem, Krasnoyarsk 660022, Russia.
EM allasalmina@mail.ru
RI Salmina, Alla/L-7977-2013
FU Russian Foundation for Basic Research and the Japan Society for the
Promotion of Science (RFBR-JSPS) [08-04-91209]
FX This work was supported by the bilateral grant 08-04-91209 of the
Russian Foundation for Basic Research and the Japan Society for the
Promotion of Science (RFBR-JSPS) (A.B.S., H.H.).
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NR 112
TC 15
Z9 15
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0953-8194
J9 J NEUROENDOCRINOL
JI J. Neuroendocrinol.
PD MAY
PY 2010
VL 22
IS 5
BP 380
EP 392
DI 10.1111/j.1365-2826.2010.01970.x
PG 13
WC Endocrinology & Metabolism; Neurosciences
SC Endocrinology & Metabolism; Neurosciences & Neurology
GA 585WW
UT WOS:000276862100008
PM 20141572
ER
PT J
AU Levy, DL
Coleman, MJ
Sung, H
Ji, F
Matthysse, S
Mendell, NR
Titone, D
AF Levy, Deborah L.
Coleman, Michael J.
Sung, Heejong
Ji, Fei
Matthysse, Steven
Mendell, Nancy R.
Titone, Debra
TI The genetic basis of thought disorder and language and communication
disturbances in schizophrenia
SO JOURNAL OF NEUROLINGUISTICS
LA English
DT Article
DE Schizophrenia; Thought disorder; Language disorders; Communication
disorders; Semantic anomalies; Genetics; Family studies; Linkage
analyses; Endophenotypes
ID AUTISM SPECTRUM DISORDER; LINKAGE ANALYSIS; FOLLOW-UP; COGNITIVE
DEFICITS; ROSCOMMON FAMILY; SPEECH DISORDER; PARENTS; FOXP2; IMPAIRMENT;
RISK
AB Thought disorder as well as language and communication disturbances are associated with schizophrenia and are over-represented in clinically unaffected relatives of schizophrenics. All three kinds of dysfunction involve some element of deviant verbalizations, most notably, semantic anomalies. Of particular importance, thought disorder characterized primarily by deviant verbalizations has a higher recurrence in relatives of schizophrenic patients than schizophrenia itself. These findings suggest that deviant verbalizations may be more penetrant expressions of schizophrenia susceptibility genes than schizophrenia. This paper reviews the evidence documenting the presence of thought, language and communication disorders in schizophrenic patients and in their first-degree relatives. This familial aggregation potentially implicates genetic factors in the etiology of thought disorder, language anomalies, and communication disturbances in schizophrenia families. We also present two examples of ways in which thought, language and communication disorders can enrich genetic studies, including those involving schizophrenia. (C) 2009 Elsevier Ltd. All rights reserved.
C1 [Levy, Deborah L.; Coleman, Michael J.; Matthysse, Steven] McLean Hosp, Psychol Res Lab, Belmont, MA 02478 USA.
[Sung, Heejong] Natl Human Genome Res Inst, Genometr Sect, Inherited Dis Res Branch, NIH, Bethesda, MD USA.
[Ji, Fei] Stat Collaborat Inc, Washington, DC USA.
[Mendell, Nancy R.] SUNY Stony Brook, Dept Appl Math & Stat, Stony Brook, NY 11794 USA.
[Titone, Debra] McGill Univ, Dept Psychol, Montreal, PQ, Canada.
RP Levy, DL (reprint author), McLean Hosp, Psychol Res Lab, 115 Mill St, Belmont, MA 02478 USA.
EM dlevy@mclean.harvard.edu
FU NIMH [R01 MH071523, MH31340]; Sidney R. Baer, Jr. Foundation; Essel
Foundation; National Association for Research on Schizophrenia and
Depression
FX This study was supported in part by NIMH grants R01 MH071523 and
MH31340, the Sidney R. Baer, Jr. Foundation, the Essel Foundation, and
the National Association for Research on Schizophrenia and Depression.
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Zeesman S, 2006, AM J MED GENET A, V140A, P509, DOI 10.1002/ajmg.a.31110
NR 164
TC 27
Z9 27
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0911-6044
J9 J NEUROLINGUIST
JI J. Neurolinguist.
PD MAY
PY 2010
VL 23
IS 3
SI SI
BP 176
EP 192
DI 10.1016/j.jneuroling.2009.08.003
PG 17
WC Linguistics; Neurosciences; Psychology, Experimental
SC Linguistics; Neurosciences & Neurology; Psychology
GA 569AC
UT WOS:000275567200002
ER
PT J
AU Hutchins, K
Nunez, M
Petito, C
AF Hutchins, Kenneth
Nunez, Mariana
Petito, Carol
TI Causes of Death and Neuropathology in Autism Spectrum Disorder: A
Medical Examiner Perspective
SO JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
LA English
DT Meeting Abstract
CT 86th Annual Meeting of the American-Association-of-Neuropathologists
CY JUN 10-13, 2010
CL Philadelphia, PA
SP Amer Assoc Neuropathologists
C1 [Nunez, Mariana; Petito, Carol] Miami Univ, Sch Med, Dept Pathol, Oxford, OH 45056 USA.
NR 0
TC 0
Z9 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0022-3069
J9 J NEUROPATH EXP NEUR
JI J. Neuropathol. Exp. Neurol.
PD MAY
PY 2010
VL 69
IS 5
MA 102
BP 547
EP 548
PG 2
WC Clinical Neurology; Neurosciences; Pathology
SC Neurosciences & Neurology; Pathology
GA 594WV
UT WOS:000277571500111
ER
PT J
AU Tekin-Iftar, E
Birkan, B
AF Tekin-Iftar, Elif
Birkan, Bunyamin
TI Small Group Instruction for Students With Autism General Case Training
and Observational Learning
SO JOURNAL OF SPECIAL EDUCATION
LA English
DT Article
DE small group teaching; autism; general case training; observational
learning; progressive time delay; food and drink preparation skills
ID TIME-DELAY PROCEDURES; DAILY LIVING SKILLS; SEVERE DISABILITIES;
ACQUISITION; RESPONSES; CHILDREN; STIMULI
AB A multiple-probe design across response chains and students was used to evaluate the combined instructional effects of progressive time delay, general case training, and observational learning on the food and drink preparation skills of three children with autism. All instruction was delivered in a group learning arrangement. The data suggested that these students acquired and maintained the targeted skills through the use of these instructional techniques. In addition, students were able to acquire response chains by observing the other student in the group and appeared to generalize the acquired skills to similar response chains. The implications for future research are discussed.
C1 [Tekin-Iftar, Elif] Anadolu Univ, Res Inst Handicapped, TR-26470 Eskisehir, Turkey.
RP Tekin-Iftar, E (reprint author), Anadolu Univ, Res Inst Handicapped, TR-26470 Eskisehir, Turkey.
EM eltekin@anadolu.edu.tr
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AULT MJ, 1988, AM J MENT RETARD, V93, P44
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NR 37
TC 6
Z9 6
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0022-4669
J9 J SPEC EDUC
JI J. Spec. Educ.
PD MAY
PY 2010
VL 44
IS 1
BP 50
EP 63
DI 10.1177/0022466908325219
PG 14
WC Education, Special
SC Education & Educational Research
GA 580PT
UT WOS:000276462100004
ER
PT J
AU Johnson, S
Hollis, C
Kochhar, P
Hennessy, E
Wolke, D
Marlow, N
AF Johnson, Samantha
Hollis, Chris
Kochhar, Puja
Hennessy, Enid
Wolke, Dieter
Marlow, Neil
TI Psychiatric Disorders in Extremely Preterm Children: Longitudinal
Finding at Age 11 Years in the EPICure Study
SO JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
LA English
DT Article
DE extremely preterm; psychiatric disorders; risk factors; ADHD; autism
ID LOW-BIRTH-WEIGHT; BEHAVIORAL OUTCOMES; DIFFICULTIES-QUESTIONNAIRE;
NEUROBEHAVIORAL OUTCOMES; DEVELOPMENTAL-DISABILITY; SOCIAL COMPETENCES;
PREMATURE BIRTH; MENTAL-HEALTH; FOLLOW-UP; BORN
AB Objective: To investigate the prevalence and risk factors for psychiatric disorders in extremely preterm children. Method: All babies born <26 weeks gestation in the United Kingdom and Ireland from March through December 1995 were recruited to the EPICure Study. Of 307 survivors at 11 years of age, 219 (71%) were assessed alongside 153 term-born classmates. Parents completed a structured psychiatric interview about their child, and teachers completed a corresponding questionnaire from which DSM-IV diagnoses were assigned for 219 (100%) extremely preterm children and 152 (99%) classmates. An IQ test and a physical evaluation were also administered. Longitudinal data were available for extremely preterm children. Results: Extremely preterm children were more than three times more likely to have a psychiatric disorder than classmates (23% vs. 9%; odds ratio [OR] = 3.2; 95% confidence interval [CI] = 1.7, 6.2). Risk was significantly increased for: attention-deficit/hyperactivity disorder (ADHD; 11.5% vs. 2.9%; OR = 4.3; CI = 1.5 to 13.0), with increased risk for ADHD inattentive subtype (OR = 10.5; CI = 1.4 to 81.1) but not ADHD combined subtype (OR = 2.1; CI = 0.5 to 7.9); emotional disorders (9.0% vs. 2.1%; OR = 4.6; CI = 1.3 to 15.9), with increased risk for anxiety disorders (OR = 3.5; CI = 1.0 to 12.4); and autism spectrum disorders (8.0% vs. 0%; p = .000). Psychiatric disorders were significantly associated with cognitive impairment (OR = 3.5; CI = 1.8 to 6.4). Parent-reported behavioral problems at 2.5 and 6 years were independent predictors of psychiatric disorders at 11 years. Conclusions: Extremely preterm children are at increased risk for ADHD, emotional disorders, and autism spectrum disorders at 11 years of age. The mechanism of association with psychiatric disorder may include both cognitive impairment and early traumatic experiences that have an impact on both child and parent. Early screening for cognitive and behavioral problems may identify those at greatest risk. J. Am. Acad. Child Adolesc. Psychiatry, 2010;49(5):453-463.
C1 [Johnson, Samantha] Univ Nottingham, Sch Clin Sci, Nottingham NG7 2RD, England.
[Johnson, Samantha] UCL, Inst Womens Hlth, London WC1E 6BT, England.
[Hollis, Chris; Kochhar, Puja] Univ Nottingham, Div Psychiat, Dev Psychiat Sect, Nottingham NG7 2RD, England.
[Hennessy, Enid] Queen Mary Univ London, Barts & London Sch Med & Dent, London, England.
[Wolke, Dieter] Univ Warwick, Hlth Sci Res Inst, Coventry CV4 7AL, W Midlands, England.
RP Hollis, C (reprint author), Queens Med Ctr, South Block,E Floor, Nottingham NG7 2UH, England.
EM chris.hollis@nottingham.ac.uk
RI Wolke, Dieter/C-5372-2008; Marlow, Neil/D-2918-2009
OI Wolke, Dieter/0000-0003-0304-268X; Marlow, Neil/0000-0001-5890-2953
FU Medical Research Council (MRC), UK
FX This study was supported by the Medical Research Council (MRC), UK.
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World Health Organisation, 1992, ICD 10 CLASS MENT BE
NR 58
TC 94
Z9 94
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0890-8567
J9 J AM ACAD CHILD PSY
JI J. Am. Acad. Child Adolesc. Psychiatr.
PD MAY
PY 2010
VL 49
IS 5
BP 453
EP 463
DI 10.1016/j.jaac.2010.02.002
PG 11
WC Psychology, Developmental; Pediatrics; Psychiatry
SC Psychology; Pediatrics; Psychiatry
GA 589FD
UT WOS:000277131100005
PM 20431465
ER
PT J
AU Lionello-DeNouf, KM
Dube, WV
McIlvane, WJ
AF Lionello-DeNouf, Karen M.
Dube, William V.
McIlvane, William J.
TI EVALUATION OF RESISTANCE TO CHANGE UNDER DIFFERENT DISRUPTER CONDITIONS
IN CHILDREN WITH AUTISM AND SEVERE INTELLECTUAL DISABILITY
SO JOURNAL OF THE EXPERIMENTAL ANALYSIS OF BEHAVIOR
LA English
DT Article
DE behavioral momentum; autism spectrum disorders; intellectual disability;
computer screen touch; human children
ID BEHAVIORAL MOMENTUM; LONGITUDINAL DATA; ATTENTION; REINFORCEMENT;
INDIVIDUALS; TRANSITIONS; EXTINCTION; SCHEDULES
AB Translational research inspired by behavioral momentum theory in the area of developmental disabilities has shown effects in individuals over a range of functioning levels. In the current study, behavioral momentum was assessed in 6 children diagnosed with autism and severe intellectual disability. In a repeated measures design, participants were exposed to relatively rich versus lean reinforcement contingencies in a multiple schedule with food reinforcers. This was followed by exposure to each of four disrupting conditions: prefeeding, presentation of a concurrent alternative stimulus, presentation of a movie, and the presence of a researcher dispensing response-independent reinforcers on a variable-time schedule. Consistently greater resistance to disruption in the component with the richer schedule occurred with the alternative stimulus disrupter but not with the other disrupters. These results suggest parameters that may be more (or less) effective if behavioral momentum inspired techniques are to be exploited in therapeutic environments.
C1 [Lionello-DeNouf, Karen M.; Dube, William V.; McIlvane, William J.] Univ Massachusetts, Sch Med, Shriver Ctr, Shrewsbury, MA 01545 USA.
RP Lionello-DeNouf, KM (reprint author), Univ Massachusetts, Sch Med, Shriver Ctr, 333 South St, Shrewsbury, MA 01545 USA.
EM Karen.Lionello-DeNolf@umassmed.edu
FU NICHD [HD 046666, HD04147]
FX This research was supported by NICHD grants HD 046666 and HD04147. The
contents of this paper are solely the responsibility of the authors and
do not necessarily represent the official views of NICHD. We thank Jeff
Kilpatrick, Steven Meyer, Emily Wheeler, and Lauren Abraham for their
assistance in data collection.
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NR 33
TC 5
Z9 5
PU SOC EXP ANALYSIS BEHAVIOR INC
PI BLOOMINGTON
PA INDIANA UNIV DEPT PSYCHOLOGY, BLOOMINGTON, IN 47405 USA
SN 0022-5002
J9 J EXP ANAL BEHAV
JI J. Exp. Anal. Behav.
PD MAY
PY 2010
VL 93
IS 3
SI SI
BP 369
EP 383
DI 10.1901/jeab.2010.93-369
PG 15
WC Psychology, Biological; Behavioral Sciences; Psychology, Experimental
SC Psychology; Behavioral Sciences
GA 595FW
UT WOS:000277597100006
PM 21119851
ER
PT J
AU Milo, JS
Mace, FC
Nevin, JA
AF Milo, Jessie-Sue
Mace, F. Charles
Nevin, John A.
TI THE EFFECTS OF CONSTANT VERSUS VARIED REINFORCERS ON PREFERENCE AND
RESISTANCE TO CHANGE
SO JOURNAL OF THE EXPERIMENTAL ANALYSIS OF BEHAVIOR
LA English
DT Article
DE behavioral momentum; resistance to change; preference; varied vs
constant reinforcers; boys with autism
ID BEHAVIORAL MOMENTUM; CHILDREN
AB Previous research has demonstrated that factors such as reinforcer frequency, amount, and delay have similar effects on resistance to change and preference. In the present study, 4 boys with autism made choices between a constant reinforcer (one that was the same food item every trial) and a varied food reinforcer (one that varied randomly between three possible food items). For all 4 boys, varied reinforcers were preferred over constant reinforcers, and they maintained higher response rates than constant reinforcers. In addition, when a distraction (a video clip) was introduced, responding maintained by varied reinforcers was more resistant to distraction than responding maintained by constant reinforcers. Thus, the present experiment extended the generality of the relation between preference and resistance to change to variation in reinforcer quality.
C1 [Milo, Jessie-Sue; Mace, F. Charles] Univ So Maine, Gorham, ME 04038 USA.
[Nevin, John A.] Univ New Hampshire, Durham, NH 03824 USA.
RP Mace, FC (reprint author), Univ So Maine, 407 Bailey Hall, Gorham, ME 04038 USA.
EM fcmace@usm.maine.edu
FU Providence's Merrymeeting Center
FX The first author thanks Lora Perry, Erin Newcomb, and Providence's
Merrymeeting Center staff and students who supported and participated in
the experimental procedure. Appreciation is also extended to Dr. Mark
Steege, Dr. Michael Kelley, and Dr. Rachel Brown-Chidsey.
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NR 16
TC 5
Z9 5
PU SOC EXP ANALYSIS BEHAVIOR INC
PI BLOOMINGTON
PA INDIANA UNIV DEPT PSYCHOLOGY, BLOOMINGTON, IN 47405 USA
SN 0022-5002
J9 J EXP ANAL BEHAV
JI J. Exp. Anal. Behav.
PD MAY
PY 2010
VL 93
IS 3
SI SI
BP 385
EP 394
DI 10.1901/jeab.2010.93-385
PG 10
WC Psychology, Biological; Behavioral Sciences; Psychology, Experimental
SC Psychology; Behavioral Sciences
GA 595FW
UT WOS:000277597100007
PM 21119852
ER
PT J
AU Daly, MB
Axilbund, JE
Buys, S
Crawford, B
Farrell, CD
Friedman, S
Garber, JE
Goorha, S
Gruber, SB
Hampel, H
AF Daly, Mary B.
Axilbund, Jennifer E.
Buys, Saundra
Crawford, Beth
Farrell, Carolyn D.
Friedman, Susan
Garber, Judy E.
Goorha, Salil
Gruber, Stephen B.
Hampel, Heather
CA NCCN Genetic Familial High-Risk
TI Genetic/Familial High-Risk Assessment: Breast and Ovarian Clinical
Practice Guidelines in Oncology
SO JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK
LA English
DT Review
DE NCCN Clinical Practice Guidelines; breast/ovarian cancer syndrome;
Li-Fraumeni syndrome; Cowden syndrome; gene; hereditary; BRCA1; BRCA2;
genetic counseling; genetic risk assessment
ID BRCA2 MUTATION CARRIERS; LI-FRAUMENI-SYNDROME; REDUCING
SALPINGO-OOPHORECTOMY; HAMARTOMA-TUMOR-SYNDROME; DIFFUSE GASTRIC-CANCER;
BILATERAL PROPHYLACTIC MASTECTOMY; HORMONE REPLACEMENT THERAPY; HEALTHY
POSTMENOPAUSAL WOMEN; AUTISM SPECTRUM DISORDERS;
RILEY-RUVALCABA-SYNDROME
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NR 182
TC 80
Z9 82
PU HARBORSIDE PRESS
PI COLD SPRING HARBOR
PA 37 MAIN ST, COLD SPRING HARBOR, NY 11724 USA
SN 1540-1405
J9 J NATL COMPR CANC NE
JI J. Natl. Compr. Cancer Netw.
PD MAY
PY 2010
VL 8
IS 5
BP 562
EP 594
PG 33
WC Oncology
SC Oncology
GA 615ZO
UT WOS:000279177500006
PM 20495085
ER
PT J
AU Larson, K
Halfon, N
AF Larson, Kandyce
Halfon, Neal
TI Family Income Gradients in the Health and Health Care Access of US
Children
SO MATERNAL AND CHILD HEALTH JOURNAL
LA English
DT Article
DE Income gradients; Health outcomes; Access; Children
ID SOCIAL-CLASS GRADIENTS; SOCIOECONOMIC-STATUS; UNITED-STATES; CHILDHOOD
ASTHMA; MEDICAL-CARE; DISPARITIES; SERVICES; AUTISM; LIFE; DIAGNOSIS
AB This study sought to examine the shape and magnitude of family income gradients in US children's health, access to care, and use of services. We analyzed cross-sectional data from the 2003 National Survey of Children's Health, a telephone survey of 102,353 parents of children aged 0-17 years. Associations between family income [Below 100% Federal Poverty Level (FPL), 100-199% FPL, 200-299% FPL, 300-399% FPL, 400% FPL or Greater] and a set of 32 health and health care indicators were examined using linear polynomial testing and multivariate logistic regression. The percentage of children in better health increased with family income for 15 health outcomes. In multivariate logistic regression models that controlled for health insurance coverage and socio-demographic confounders, odds ratios > 2 comparing the lowest to the highest income groups were noted for health conditions across both physical and developmental domains (diabetes, headaches, ear infections, learning disabilities, behavior/conduct problems, speech problems). Parent-reported global child health status, activity limitation, and oral health status showed steeper gradients than specific chronic and acute conditions. Ten measures of health care access and utilization were associated with family income in multivariate logistic regression models. Income gradients are pervasive across many health indicators at an early age. Social and health policy interventions are needed to address the multitude of factors that can affect children's health and initiate disparities in development.
C1 [Larson, Kandyce; Halfon, Neal] Univ Calif Los Angeles, Ctr Healthier Children Families & Communities, Los Angeles, CA 90024 USA.
[Larson, Kandyce; Halfon, Neal] Univ Calif Los Angeles, David Geffen Sch Med, Dept Pediat, Los Angeles, CA 90024 USA.
[Halfon, Neal] Univ Calif Los Angeles, Sch Publ Hlth, Dept Hlth Serv, Los Angeles, CA 90024 USA.
[Halfon, Neal] Univ Calif Los Angeles, Sch Publ Affairs, Dept Publ Policy, Los Angeles, CA 90024 USA.
RP Larson, K (reprint author), Univ Calif Los Angeles, Ctr Healthier Children Families & Communities, 10990 Wilshire Blvd,Suite 900, Los Angeles, CA 90024 USA.
EM kandyce@ucla.edu
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NR 53
TC 30
Z9 31
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1092-7875
J9 MATERN CHILD HLTH J
JI Matern. Child Health J.
PD MAY
PY 2010
VL 14
IS 3
BP 332
EP 342
DI 10.1007/s10995-009-0477-y
PG 11
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 590RD
UT WOS:000277244000003
PM 19499315
ER
PT J
AU Pinborough-Zimmerman, J
Bilder, D
Satterfield, R
Hossain, S
McMahon, W
AF Pinborough-Zimmerman, Judith
Bilder, Deborah
Satterfield, Robert
Hossain, Shaheen
McMahon, William
TI The Impact of Surveillance Method and Record Source on Autism
Prevalence: Collaboration with Utah Maternal and Child Health Programs
SO MATERNAL AND CHILD HEALTH JOURNAL
LA English
DT Article
DE Autism spectrum disorders; Surveillance; Prevalence; Maternal child
health; Epidemiology
ID SPECTRUM DISORDERS; SPECIAL-EDUCATION; TRENDS
AB With the increasing number of Utah children identified with autism spectrum disorders (ASDs), information on the prevalence and characteristics of these children could help Maternal Child Health (MCH) programs develop population building activities focused on prevention, screening, and education. The purpose of this study is to describe Utah's autism registry developed in collaboration with state MCH programs and assess the impact of different record-based surveillance methods on state ASD prevalence rates. The study was conducted using 212 ASD cases identified from a population of 26,217 eight year olds living in one of the three most populous counties in Utah (Davis, Salt Lake, and Utah) in 2002. ASD prevalence was determined using two records based approaches (administrative diagnoses versus abstraction and clinician review) by source of record ascertainment (education, health, and combined). ASD prevalence ranged from 7.5 per 1000 (95% CI 6.4-8.5) to 3.2 per 1000 (95% CI 2.5-3.9) varying significantly (P < .05) based on method and record source. The ratio of male-to-female ranged from 4.7:1 to 6.4:1. No significant differences were found between the two case ascertainment methods on 18 of the 23 case characteristics including median household income, parental education, and mean age of diagnosis. Broad support is needed from both education and health sources as well as collaboration with MCH programs to address the growing health concerns, monitoring, and treatment needs of children and their families impacted by autism spectrum disorders.
C1 [Pinborough-Zimmerman, Judith; Bilder, Deborah; McMahon, William] Univ Utah, Dept Psychiat, Salt Lake City, UT 84112 USA.
[Satterfield, Robert; Hossain, Shaheen] Utah Dept Hlth, Salt Lake City, UT 84116 USA.
RP Pinborough-Zimmerman, J (reprint author), Univ Utah, Dept Psychiat, Salt Lake City, UT 84112 USA.
EM judith.zimmerman@hsc.utah.edu
CR Autism and Developmental Disabilities Monitoring Network Surveillance Year 2002 Principal Investigators, 2007, MMWR-MORBID MORTAL W, V56, P12
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UTAH REGISTRY AUTISM
NR 23
TC 5
Z9 5
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1092-7875
J9 MATERN CHILD HLTH J
JI Matern. Child Health J.
PD MAY
PY 2010
VL 14
IS 3
BP 392
EP 400
DI 10.1007/s10995-009-0472-3
PG 9
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 590RD
UT WOS:000277244000010
PM 19475366
ER
PT J
AU Hadjikhani, N
AF Hadjikhani, Nouchine
TI Serotonin, pregnancy and increased autism prevalence: Is there a link?
SO MEDICAL HYPOTHESES
LA English
DT Article
ID REUPTAKE INHIBITORS; PLATELET SEROTONIN; 1ST-DEGREE RELATIVES;
TRYPTOPHAN DEPLETION; SPECTRUM DISORDERS; MENTAL-RETARDATION; OXYTOCIN;
CHILDREN; AMYGDALA; BRAIN
AB The prevalence of autism, a neurodevelopmental condition resulting from genetic and environmental causes, has increased dramatically during the last decade. Among the potential environmental factors, hyperserotonemia during pregnancy and its effect on brain development could be playing a role in this prevalence raise. In the rodent model developed by Whitaker-Azmitia and colleagues, hyperserotonemia during fetal development results in a dysfunction of the hypothalamo-pituitary axis, affecting the amygdala as well as pro-social hormone oxytocin regulation.
Dysfunction of the amygdala and abnormal oxytocin levels may underlie many clinical features of ASD. Selective serotonin reuptake inhibitors (SSRI) are the most widely used class of antidepressants drugs, and they are not contraindicated during pregnancy. In this paper, we hypothesize that increased serotonemia during pregnancy, including due to SSRI intake, could be one of the causes of the raising prevalence in autism. If our hypothesis is confirmed, it will not only shed light on one of the possible reason for autism prevalence, but also offer new preventive and treatment options. (C) 2009 Elsevier Ltd. All rights reserved.
C1 [Hadjikhani, Nouchine] MGH MIT HMS Martinos Ctr Biomed Imaging, Charlestown, MA USA.
[Hadjikhani, Nouchine] EPFL Lausanne, Brain Mind Inst, Lausanne, Switzerland.
RP Hadjikhani, N (reprint author), EPFL SV BMI AAB 133, Stn 15, CH-1015 Lausanne, Switzerland.
EM nouchine@nmr.mgh.harvard.edu
RI Hadjikhani, Nouchine/C-2018-2008
OI Hadjikhani, Nouchine/0000-0003-4075-3106
FU Swiss National Foundation [PP00B-110741]
FX This work was supported by the Swiss National Foundation Grant
PP00B-110741 to NH.
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NR 67
TC 17
Z9 17
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0306-9877
J9 MED HYPOTHESES
JI Med. Hypotheses
PD MAY
PY 2010
VL 74
IS 5
BP 880
EP 883
DI 10.1016/j.mehy.2009.11.015
PG 4
WC Medicine, Research & Experimental
SC Research & Experimental Medicine
GA 599BY
UT WOS:000277886400031
PM 20018455
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PT J
AU Gericke, GS
AF Gericke, G. S.
TI Common chromosomal fragile sites (CFS) may be involved in normal and
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SO MEDICAL HYPOTHESES
LA English
DT Article
ID RECOMBINATION-ACTIVATING GENE-1; AUTISM SPECTRUM DISORDERS; HUMAN BRAIN
EVOLUTION; SEGMENTAL DUPLICATIONS; HUMAN GENOME; EPIGENETIC MECHANISMS;
CELL-ADHESION; RETT-SYNDROME; TRANSCRIPTION; EXPRESSION
AB Previous reports of specific patterns of increased fragility at common chromosomal fragile sites (CFS) found in association with certain neurobehavioural disorders did not attract attention at the time due to a shift towards molecular approaches to delineate neuropsychiatric disorder candidate genes. Links with miRNA, altered methylation and the origin of copy number variation indicate that CFS region characteristics may be part of chromatinomic mechanisms that are increasingly linked with neuroplasticity and memory. Current reports of large-scale double-stranded DNA breaks in differentiating neurons and evidence of ongoing DNA demethylation of specific gene promoters in adult hippocampus may shed new light on the dynamic epigenetic changes that are increasingly appreciated as contributing to long-term memory consolidation. The expression of immune recombination activating genes in key stress-induced memory regions suggests the adoption by the brain of this ancient pattern recognition and memory system to establish a structural basis for long-term memory through controlled chromosomal breakage at highly specific genomic regions. It is furthermore considered that these mechanisms for management of epigenetic information related to stress memory could be linked, in some instances, with the transfer of the somatically acquired information to the germline. Here, rearranged sequences can be subjected to further selection and possible eventual retrotranscription to become part of the more stable coding machinery if proven to be crucial for survival and reproduction. While linkage of cognitive memory with stress and fear circuitry and memory establishment through structural DNA modification is proposed as a normal process, inappropriate activation of immune-like genomic rearrangement processes through traumatic stress memory may have the potential to lead to undesirable activation of neuro-inflammatory processes. These theories could have a significant impact on the interpretation of risks posed by heredity and the environment and the search for neuropsychiatric candidate genes. (C) 2009 Published by Elsevier Ltd.
C1 Tshwane Univ Technol, Dept Biomed Sci, ZA-0075 Pretoria, Gauteng, South Africa.
RP Gericke, GS (reprint author), Tshwane Univ Technol, Dept Biomed Sci, POB 2040,Brooklyn Sq, ZA-0075 Pretoria, Gauteng, South Africa.
EM gerickegs@webmail.co.za
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NR 112
TC 0
Z9 0
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0306-9877
J9 MED HYPOTHESES
JI Med. Hypotheses
PD MAY
PY 2010
VL 74
IS 5
BP 911
EP 918
DI 10.1016/j.mehy.2009.05.039
PG 8
WC Medicine, Research & Experimental
SC Research & Experimental Medicine
GA 599BY
UT WOS:000277886400037
PM 20138440
ER
PT J
AU Brang, D
Ramachandran, VS
AF Brang, David
Ramachandran, V. S.
TI Olfactory bulb dysgenesis, mirror neuron system dysfunction, and
autonomic dysregulation as the neural basis for autism
SO MEDICAL HYPOTHESES
LA English
DT Article
ID SPECTRUM DISORDERS; OXYTOCIN; CHILDREN; VOLUME; SCHIZOPHRENIA; BEHAVIORS
AB Autism is a disorder characterized by social withdrawal, impoverished language and empathy, and a profound inability to adopt another's viewpoint - a failure to construct a "theory of mind" for interpreting another person's thoughts and intentions. We previously showed that these symptoms might be explained, in part, by a paucity of mirror neurons. Prompted by an MRI report of an individual with autism, we now suggest that there may be, in addition, a congenital aplasia/dysplasia of the olfactory bulbs with consequent reduction of vasopressin and oxytocin receptor binding. There may also be sub-clinical temporal lobe epilepsy affecting the recently discovered third visual system that is rich in "empathy" related mirror neurons (MNS) and projects (via the TOP junction - just below the inferior parietal lobule) to limbic structures that regulate autonomic outflow. This causes deranged autonomic feedback, resulting in additional deficiencies in MNS with loss of emotional empathy and introspection. (C) 2009 Published by Elsevier Ltd.
C1 [Brang, David; Ramachandran, V. S.] Univ Calif San Diego, Ctr Brain & Cognit, La Jolla, CA 92093 USA.
RP Ramachandran, VS (reprint author), Univ Calif San Diego, Ctr Brain & Cognit, La Jolla, CA 92093 USA.
EM vramacha@ucsd.edu
RI Brang, David/G-5326-2012
FU ASD
FX We thank Herb Lurie - who independently came up with the mirror neuron
theory of ASD - for partially funding this research.
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NR 23
TC 6
Z9 6
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0306-9877
J9 MED HYPOTHESES
JI Med. Hypotheses
PD MAY
PY 2010
VL 74
IS 5
BP 919
EP 921
DI 10.1016/j.mehy.2008.11.048
PG 3
WC Medicine, Research & Experimental
SC Research & Experimental Medicine
GA 599BY
UT WOS:000277886400038
PM 20149551
ER
PT J
AU Kuno, K
Ishii, Y
Ueda, T
Kurokawa, T
Chen, ZY
Tanaka, T
Tominaga, R
Watanabe, K
AF Kuno, Katashi
Ishii, Yoshimasa
Ueda, Takashi
Kurokawa, Takashi
Chen, Zhouye
Tanaka, Toru
Tominaga, Ryo
Watanabe, Kazuhiko
TI The Effects Of Physical Training On Standing Long Jump Among The People
With Autism And The Down Syndrome
SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
LA English
DT Meeting Abstract
CT 57th Annual Meeting of the American-College-Sports-Medicine/Inaugural
World Congress on Exercise is Medicine
CY JUN 05, 2010
CL Baltimore, MD
SP Amer Coll Sports Med
C1 [Kuno, Katashi; Ishii, Yoshimasa; Ueda, Takashi; Kurokawa, Takashi; Chen, Zhouye; Tanaka, Toru; Tominaga, Ryo; Watanabe, Kazuhiko] Hiroshima Univ, Higashihiroshima 724, Japan.
NR 0
TC 0
Z9 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0195-9131
J9 MED SCI SPORT EXER
JI Med. Sci. Sports Exerc.
PD MAY
PY 2010
VL 42
IS 5
SU 1
MA 1610
BP 335
EP 336
PG 2
WC Sport Sciences
SC Sport Sciences
GA 759FO
UT WOS:000290226301266
ER
PT J
AU Hand, BD
Bush, JA
Crabtree, L
Newhouse, R
Fagan, L
Stinar, R
AF Hand, Brian D.
Bush, Jill A.
Crabtree, Lisa
Newhouse, Rebecca
Fagan, Lisa
Stinar, Raymond
TI The Influence of Exercise on Neuromuscular Function in Adults on the
Autism Spectrum
SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
LA English
DT Meeting Abstract
CT 57th Annual Meeting of the American-College-Sports-Medicine/Inaugural
World Congress on Exercise is Medicine
CY JUN 05, 2010
CL Baltimore, MD
SP Amer Coll Sports Med
C1 [Hand, Brian D.; Bush, Jill A.; Crabtree, Lisa; Newhouse, Rebecca; Fagan, Lisa; Stinar, Raymond] Towson Univ, Towson, MD USA.
EM BHand@towson.edu
NR 0
TC 0
Z9 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0195-9131
J9 MED SCI SPORT EXER
JI Med. Sci. Sports Exerc.
PD MAY
PY 2010
VL 42
IS 5
SU 1
MA 1960
BP 459
EP 459
PG 1
WC Sport Sciences
SC Sport Sciences
GA 759FO
UT WOS:000290226301614
ER
PT J
AU Pan, CY
Hsieh, KW
Tsai, CL
AF Pan, Chien-Yu
Hsieh, Kai-Wen
Tsai, Chia-Liang
TI Motivation and Physical Activity of Adolescents With and Without Autism
in Inclusive Physical Education
SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
LA English
DT Meeting Abstract
CT 57th Annual Meeting of the American-College-Sports-Medicine/Inaugural
World Congress on Exercise is Medicine
CY JUN 05, 2010
CL Baltimore, MD
SP Amer Coll Sports Med
C1 [Pan, Chien-Yu] Natl Kaohsiung Normal Univ, Kaohsiung, Taiwan.
[Hsieh, Kai-Wen; Tsai, Chia-Liang] Natl Cheng Kung Univ, Tainan 70101, Taiwan.
EM chpan@nknucc.nknu.edu.tw
NR 0
TC 0
Z9 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0195-9131
J9 MED SCI SPORT EXER
JI Med. Sci. Sports Exerc.
PD MAY
PY 2010
VL 42
IS 5
SU 1
MA 2133
BP 519
EP 520
PG 2
WC Sport Sciences
SC Sport Sciences
GA 759FO
UT WOS:000290226301787
ER
PT J
AU Hogart, A
Wu, D
LaSalle, JM
Schanen, NC
AF Hogart, Amber
Wu, David
LaSalle, Janine M.
Schanen, N. Carolyn
TI The comorbidity of autism with the genomic disorders of chromosome
15q11.2-q13
SO NEUROBIOLOGY OF DISEASE
LA English
DT Review
DE Autism; Autism spectrum disorders; Prader-Willi syndrome; Angelman
syndrome; Interstitial duplication chromosome 15; Isodicentric
chromosome 15; Low copy repeats; Imprinting
ID PRADER-WILLI-SYNDROME; SYNDROME CRITICAL REGION; PERVASIVE DEVELOPMENTAL
DISORDERS; AMINOBUTYRIC-ACID RECEPTOR; ANGELMAN SYNDROME GENE; INV
DUP(15); PROXIMAL 15Q; UNIPARENTAL DISOMY; IMPRINTING-CENTER;
INTERSTITIAL DUPLICATIONS
AB A cluster of low copy repeats on the proximal long arm of chromosome 15 mediates various forms of stereotyped deletions and duplication events that cause a group of neurodevelopmental disorders that are associated with autism or autism spectrum disorders (ASD). The region is subject to genomic imprinting and the behavioral phenotypes associated with the chromosome 15q11.2-q13 disorders show a parent-of-origin specific effect that suggests that an increased copy number of maternally derived alleles contributes to autism susceptibility. Notably, nonimprinted, biallelically expressed genes within the interval also have been shown to be misexpressed in brains of patients with chromosome 15q11.2-q13 genomic disorders, indicating that they also likely play a role in the phenotypic outcome. This review provides an overview of the phenotypes of these disorders and their relationships with ASD and outlines the regional genes that may contribute to the autism susceptibility imparted by copy number variation of the region. (C) 2008 Elsevier Inc. All rights reserved.
C1 [Hogart, Amber; LaSalle, Janine M.] Univ Calif Davis, Dept Med Microbiol & Immunol, Davis, CA 95616 USA.
[Wu, David; Schanen, N. Carolyn] Univ Delaware, Dept Biol Sci, Newark, DE 19716 USA.
[Schanen, N. Carolyn] Alfred I duPont Hosp Children, Nemours Biomed Res, Wilmington, DE 19803 USA.
[Schanen, N. Carolyn] Thomas Jefferson Univ, Jefferson Med Coll, Dept Pediat, Philadelphia, PA 19107 USA.
RP Schanen, NC (reprint author), Alfred I duPont Hosp Children, Nemours Biomed Res, 1600 Rockland Rd,Room RC1-241, Wilmington, DE 19803 USA.
EM schanen@medsci.udel.edu
RI LaSalle, Janine/A-4643-2008
OI LaSalle, Janine/0000-0002-3480-2031
FU National Institutes of Health [NIH F31 MH078377, NIH R01 HD48799, NIH
P3P01 HD35470, NIH R01 HD37874, P20-RR020173]; Nemours
FX The authors are supported by grants from the National Institutes of
Health [NIH F31 MH078377 (AH), NIH R01 HD48799 (JML), NIH P3P01 HD35470
(NCS), NIH R01 HD37874 (NCS), P20-RR020173 (NCS)], and Nemours (NCS and
DW). We are indebted to the Isodicentric Exchange, Advocacy and Support
Group and families with idic(15) for their participation in the ongoing
research into the investigation of the phenotype of patients with
idic(15) and interstitial duplication 15 chromosomes. The authors also
thank Suzanne Cassidy for providing detailed information on an
unpublished case interstitial triplication chromosome 15 and the
relationship with PWS and ASD.
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NR 161
TC 75
Z9 75
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0969-9961
J9 NEUROBIOL DIS
JI Neurobiol. Dis.
PD MAY
PY 2010
VL 38
IS 2
SI SI
BP 181
EP 191
DI 10.1016/j.nbd.2008.08.011
PG 11
WC Neurosciences
SC Neurosciences & Neurology
GA 590UN
UT WOS:000277253900006
PM 18840528
ER
PT J
AU Kosaka, H
Omori, M
Munesue, T
Ishitobi, M
Matsumura, Y
Takahashi, T
Narita, K
Murata, T
Saito, DN
Uchiyama, H
Morita, T
Kikuchi, M
Mizukami, K
Okazawa, H
Sadato, N
Wada, Y
AF Kosaka, Hirotaka
Omori, Masao
Munesue, Toshio
Ishitobi, Makoto
Matsumura, Yukiko
Takahashi, Tetsuya
Narita, Kousuke
Murata, Tetsuhito
Saito, Daisuke N.
Uchiyama, Hitoshi
Morita, Tomoyo
Kikuchi, Mitsuru
Mizukami, Kimiko
Okazawa, Hidehiko
Sadato, Norihiro
Wada, Yuji
TI Smaller insula and inferior frontal volumes in young adults with
pervasive developmental disorders
SO NEUROIMAGE
LA English
DT Article
DE Pervasive developmental disorders (PDD); Autistic spectrum disorders
(ASD); Voxel-based morphometry (VBM); Insula; Inferior frontal gyrus
(IFG); Mirror neuron system (MNS)
ID VOXEL-BASED MORPHOMETRY; MIRROR-NEURON SYSTEM; AUTISM-SPECTRUM;
COMMUNICATION DISORDERS; DIAGNOSTIC INTERVIEW; FUNCTIONING AUTISM;
ASPERGERS-SYNDROME; PREFRONTAL CORTEX; CHILDHOOD AUTISM; BRAIN STRUCTURE
AB Enlarged head circumference and increased brain weight have been reported in infants with pervasive developmental disorders (PDD), and volumetric studies suggest that children with POD have abnormally enlarged brain volumes. However, little is known about brain volume abnormalities in young adults with PDD. We explored gray matter (GM) volume in young adults with POD. T1-weighted volumetric images were acquired with a 3-T magnetic resonance scanner from 32 males with high-functioning PDD (23.8 +/- 4.2 years: Full Scale Intelligence Quotient [FSIQ] = 101.6 +/- 15.6) and 40 age-matched normal male control subjects (22.5 +/- 4.3 years: FSIQ = 109.7 +/- 7.9). Regional GM volumes were compared between the two groups using voxel-based morphometry (VBM) with the Diffeomorphic Anatomical Registration using Exponentiated Lie algebra (DARTEL). Compared with the control group, the high-functioning PDD group showed significantly less GM in the right insula, the right inferior frontal gyrus, and the right inferior parietal lobule. A conservative threshold confirmed considerably smaller volumes in the right insula and inferior frontal gyrus. In these areas, negative correlations were found between Autism Spectrum Quotient scores and GM volume, although no significant correlations were found between each subject's FSIQ and GM volume. No regions showed greater GM volumes in the high-functioning POD group. The insular cortex. which works as a relay area for multiple neurocognitive systems, may be one of the key regions underlying the complex clinical features of PDD. These smaller GM volumes in high-functioning PDD subjects may reflect the clinical features of PDD itself, rather than FSIQ. (C) 2010 Elsevier Inc. All rights reserved.
C1 [Kosaka, Hirotaka; Ishitobi, Makoto; Matsumura, Yukiko; Takahashi, Tetsuya; Narita, Kousuke; Murata, Tetsuhito; Wada, Yuji] Univ Fukui, Dept Neuropsychiat, Fac Med Sci, Fukui 9101193, Japan.
[Kosaka, Hirotaka; Okazawa, Hidehiko; Sadato, Norihiro] Univ Fukui, Biomed Imaging Res Ctr, Fukui 9101193, Japan.
[Omori, Masao] Fukui Prefectural Univ, Fac Nursing & Social Welf Sci, Fukui 9101195, Japan.
[Munesue, Toshio] Kanazawa Univ, Res Ctr Child Mental Dev, Kanazawa, Ishikawa 9208641, Japan.
[Narita, Kousuke] Gunma Univ, Grad Sch Med, Dept Psychiat & Human Behav, Gunma 3718511, Japan.
[Saito, Daisuke N.] Univ Fukui, Res & Educ Program Life Sci, Fukui 9101193, Japan.
[Uchiyama, Hitoshi] Tottori Univ, Fac Reg Sci, Dept Educ, Tottori 6900265, Japan.
[Morita, Tomoyo] Natl Inst Nat Sci, Natl Inst Physiol Sci, Dept Sensory Motor Integrat, Okazaki, Aichi 4448585, Japan.
[Kikuchi, Mitsuru] Kanazawa Univ, Grad Sch Med Sci, Dept Psychiat & Neurobiol, Kanazawa, Ishikawa 9208641, Japan.
[Mizukami, Kimiko] Jin Ai Univ, Fac Human Studies, Dept Psychol, Fukui 9158586, Japan.
[Sadato, Norihiro] Japan Sci & Technol Agcy & Technol Soc RISTEX, Kawaguchi, Saitama 3320012, Japan.
[Sadato, Norihiro] Natl Inst Nat Sci, Natl Inst Physiol Sci, Dept Cerebral Res, Okazaki, Aichi 4448585, Japan.
RP Kosaka, H (reprint author), Univ Fukui, Dept Neuropsychiat, Fac Med Sci, Fukui 9101193, Japan.
EM hirotaka@u-fukui.ac.jp
FU Japan Society for the Promotion of Science [17100003, 17209040,
21791120, 21220005]; Ministry of Education, Culture, Sports, Science and
Technology of Japan
FX This study was funded in part by the Fukui Prefectural Government's
Grant-in-Aid for Collaboration Research Projects and Grants-in-Aid for
Scientific Research from the Japan Society for the Promotion of Science
(17100003, 17209040, 21791120, and 21220005). Part of this study is the
result of the project "Development of biomarker candidates for social
behavior", which was carried out under the Strategic Research Program
for Brain Sciences by the Ministry of Education, Culture, Sports,
Science and Technology of Japan.
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NR 62
TC 36
Z9 38
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 1053-8119
J9 NEUROIMAGE
JI Neuroimage
PD MAY 1
PY 2010
VL 50
IS 4
BP 1357
EP 1363
DI 10.1016/j.neuroimage.2010.01.085
PG 7
WC Neurosciences; Neuroimaging; Radiology, Nuclear Medicine & Medical
Imaging
SC Neurosciences & Neurology; Radiology, Nuclear Medicine & Medical Imaging
GA 574VY
UT WOS:000276023500002
PM 20123027
ER
PT J
AU Redcay, E
Dodell-Feder, D
Pearrow, MJ
Mavros, PL
Kleiner, M
Gabrieli, JDE
Saxe, R
AF Redcay, Elizabeth
Dodell-Feder, David
Pearrow, Mark J.
Mavros, Penelope L.
Kleiner, Mario
Gabrieli, John D. E.
Saxe, Rebecca
TI Live face-to-face interaction during fMRI: A new tool for social
cognitive neuroscience
SO NEUROIMAGE
LA English
DT Article
ID SUPERIOR TEMPORAL SULCUS; JOINT ATTENTION; NEURAL BASIS; PERCEPTION;
AUTISM; GAZE; INTENTIONS; OTHERS; EXPERIENCE; REGION
AB Cooperative social interaction is critical for human social development and learning. Despite the importance of social interaction, previous neuroimaging studies lack two fundamental components of everyday face-to-face interactions: contingent responding and joint attention. In the current studies, functional MRI data were collected while participants interacted with a human experimenter face-to-face via live video feed as they engaged in simple cooperative games. In Experiment 1, participants engaged in a live interaction with the experimenter ("Live") or watched a video of the same interaction ("Recorded"). During the "Live" interaction, as compared to the Recorded conditions, greater activation was seen in brain regions involved in social cognition and reward, including the right temporoparietal junction (rTPJ), anterior cingulate cortex (ACC), right superior temporal sulcus (rSTS), ventral striatum, and amygdala. Experiment 2 isolated joint attention, a critical component of social interaction. Participants either followed the gaze of the live experimenter to a shared target of attention ("Joint Attention") or found the target of attention alone while the experimenter was visible but not sharing attention ("Solo Attention"). The right temporoparietal junction and right posterior STS were differentially recruited during Joint, as compared to Solo, attention. These findings suggest the rpSTS and rTPJ are key regions for both social interaction and joint attention. This method of allowing online, contingent social interactions in the scanner could open up new avenues of research in social cognitive neuroscience, both in typical and atypical populations. (C) 2010 Elsevier Inc. All rights reserved.
C1 [Redcay, Elizabeth; Dodell-Feder, David; Pearrow, Mark J.; Mavros, Penelope L.; Gabrieli, John D. E.; Saxe, Rebecca] MIT, Dept Brain & Cognit Sci, Cambridge, MA 02139 USA.
[Kleiner, Mario] Max Planck Inst Biol Cybernet, Dept Human Percept Cognit & Act, D-72076 Tubingen, Germany.
RP Redcay, E (reprint author), MIT, Dept Brain & Cognit Sci, 43 Vassar St, Cambridge, MA 02139 USA.
EM redcay@mit.edu
RI Redcay, Elizabeth/C-7818-2011
FU Simons Foundation; National Research Service
FX We thank Rebecca Cox for help with data collection, Jasmine Wang for
assistance with figures, and Dr. Marina Bedny, Mike Frank, Dr. Frida
Polli, Zeynep Saygin, and Todd Thompson for discussion of the analyses
and manuscript. We also thank Steve Shannon, Dr. Oliver Hinds and Todd
Thompson for technical advice and Dr. Christina Triantafyllou for
assistance with scanner protocols. We are grateful to the Simons
Foundation for funding awarded to RS for this project and for an NIH
Postdoctoral National Research Service Award for support of ER.
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NR 37
TC 89
Z9 95
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 1053-8119
J9 NEUROIMAGE
JI Neuroimage
PD MAY 1
PY 2010
VL 50
IS 4
BP 1639
EP 1647
DI 10.1016/j.neuroimage.2010.01.052
PG 9
WC Neurosciences; Neuroimaging; Radiology, Nuclear Medicine & Medical
Imaging
SC Neurosciences & Neurology; Radiology, Nuclear Medicine & Medical Imaging
GA 574VY
UT WOS:000276023500031
PM 20096792
ER
PT J
AU Cabanyes-Truffino, J
AF Cabanyes-Truffino, J.
TI Neurological signs in the adult with fragile-X premutation
SO NEUROLOGIA
LA Spanish
DT Article
DE Fragile X permutation; Tremor/ataxia syndrome; Parkinsonism; Cognitive
deficit
ID TREMOR/ATAXIA SYNDROME FXTAS; PREMATURE OVARIAN FAILURE; FMR1
MESSENGER-RNA; CGG-REPEAT LENGTH; ESSENTIAL TREMOR; FULL-MUTATION;
MOVEMENT-DISORDERS; PARKINSON-DISEASE; BRAIN ANATOMY; MALE CARRIERS
AB Introduction: Fragile X syndrome is an inherited form of mental retardation. It results from an abnormally expanded number of trinucleotide CGG repeats. Some grandfathers of these children become forgetful, have frequent falls and other neurological problems. Researchers have found a connection between fragile X syndrome and the neurological symptoms in elderly men. This resulted in the recognition of a syndrome originally referred to as "intention tremor, parkinsonism and generalised brain atrophy in carriers of a fragile X premutation". This premutation is also associated with premature ovarian failure.
Methodology: This paper reviews the literature on the neurological signs of fragile X premutation.
Conclusions: Fragile X premutation is a risk for movement disorders and cognitive dysfunction and it should be considered in patients with a family history of mental retardation or autism, and particularly in those females with premature ovarian failure. (C) 2009 Sociedad Espanola de Neurologia. Published by Elsevier Espana, S.L. All rights reserved.
C1 Univ Complutense, Dept Neurol & Neurocirugia, Univ Navarra Clin, Secc Dept Personolidad,Fac Educ, E-28040 Madrid, Spain.
RP Cabanyes-Truffino, J (reprint author), Univ Complutense, Dept Neurol & Neurocirugia, Univ Navarra Clin, Secc Dept Personolidad,Fac Educ, E-28040 Madrid, Spain.
EM jcabanyes@unav.es
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NR 78
TC 0
Z9 0
PU ELSEVIER DOYMA SL
PI BARCELONA
PA TRAVESERA DE GARCIA, 17-21, BARCELONA, 08021, SPAIN
SN 0213-4853
J9 NEUROLOGIA
JI Neurologia
PD MAY
PY 2010
VL 25
IS 4
BP 222
EP 227
DI 10.1016/j.nrl.2010.01.001
PG 6
WC Clinical Neurology
SC Neurosciences & Neurology
GA 737MT
UT WOS:000288573600003
PM 20609299
ER
PT J
AU Brieber, S
Herpertz-Dahlmann, B
Fink, GR
Kamp-Becker, I
Remschmidt, H
Konrad, K
AF Brieber, Sarah
Herpertz-Dahlmann, Beate
Fink, Gereon R.
Kamp-Becker, Inge
Remschmidt, Helmut
Konrad, Kerstin
TI Coherent motion processing in autism spectrum disorder (ASD): An fMRI
study
SO NEUROPSYCHOLOGIA
LA English
DT Article
DE Autism; Functional MRI; Visual; Motion perception
ID HIGH-FUNCTIONING AUTISM; VISUAL-MOTION; CYTOARCHITECTONIC MAPS; HUMAN
BRAIN; PERCEPTION; CHILDREN; FORM; PERFORMANCE; TASK; UNDERCONNECTIVITY
AB A deficit in global motion processing caused by a specific dysfunction of the visual dorsal pathway has been suggested to underlie perceptual abnormalities in subjects with autism spectrum disorders (ASD). However, the neural mechanisms associated with abnormal motion processing in ASD remain poorly understood. We investigated brain responses related to the detection of coherent and random motion in 15 male subjects with ASD and 15 age- and IQ-matched healthy controls (aged 13-19 years) using event-related functional magnetic resonance imaging (fMRI). Behaviorally, no significant group differences were observed between subjects with ASD and controls. Neurally, subjects with ASD showed increased brain activation in the left primary visual cortex across all conditions compared with controls. A significant interaction effect between group and condition was observed in the right superior parietal cortex resulting from increased neural activity in the coherent compared with the random motion conditions only in the control group. In addition, neural activity in area V5 was not differentially modulated by specific motion conditions in subjects with ASD. Functional connectivity analyses revealed positive correlations between the primary visual cortex and area V5 within both hemispheres, but no significant between-group differences in functional connectivity patterns along the dorsal stream. The data suggest that motion processing in ASD results in deviant activations in both the lower and higher processing stages of the dorsal pathway. This might reflect differences in the perception of visual stimuli in ASD, which possibly result in impaired integration of motion signals. (C) 2010 Elsevier Ltd. All rights reserved.
C1 [Brieber, Sarah; Konrad, Kerstin] Univ Hosp RWTH Aachen, Child Neuropsychol Sect, Dept Child & Adolescent Psychiat & Psychotherapy, D-52074 Aachen, Germany.
[Brieber, Sarah; Fink, Gereon R.] Res Ctr Juelich, Inst Neurosci & Med INM 3, Cognit Neurol Sect, Julich, Germany.
[Fink, Gereon R.] Univ Hosp Cologne, Dept Neurol, Cologne, Germany.
[Kamp-Becker, Inge; Remschmidt, Helmut] Univ Marburg, Dept Child & Adolescent Psychiat, D-35032 Marburg, Germany.
RP Konrad, K (reprint author), Univ Hosp RWTH Aachen, Child Neuropsychol Sect, Dept Child & Adolescent Psychiat & Psychotherapy, D-52074 Aachen, Germany.
EM kkonrad@ukaachen.de
RI Konrad, Kerstin/H-7747-2013; Fink, Gereon/E-1616-2012
OI Konrad, Kerstin/0000-0001-9039-2615; Fink, Gereon/0000-0002-8230-1856
FU AstraZeneca; Eli Lilly; Novartis; Janssen Cilag; Interdisciplinary
Centre for Clinical Research [IZKF N68a]
FX Dr. Herpertz-Dahlmann is a consultant for Eli Lilly and has received
industry research funding from AstraZeneca, Eli Lilly, Novartis, and
Janssen Cilag. The other authors declare that no conflicts of interest
exist.We are grateful to all our volunteers and our colleagues at the
Institute of Neuroscience and Biophysics, Department of Medicine,
Research Center Juelich. Furthermore we wish to thank Andre Knops for
his support in programming the experiment and Ralph Weidner for his
helpful comments on an earlier version of the manuscript. This study was
supported by a grant to K.K. and G.R.F. by the Interdisciplinary Centre
for Clinical Research (IZKF N68a).
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WHO, 1993, ICD 10 CLASS MENT BE
NR 57
TC 20
Z9 21
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0028-3932
J9 NEUROPSYCHOLOGIA
JI Neuropsychologia
PD MAY
PY 2010
VL 48
IS 6
BP 1644
EP 1651
DI 10.1016/j.neuropsychologia.2010.02.007
PG 8
WC Behavioral Sciences; Neurosciences; Psychology, Experimental
SC Behavioral Sciences; Neurosciences & Neurology; Psychology
GA 604FE
UT WOS:000278261900012
PM 20153764
ER
PT J
AU Lackner, CL
Bowman, LC
Sabbagh, MA
AF Lackner, Christine L.
Bowman, Lindsay C.
Sabbagh, Mark A.
TI Dopaminergic functioning and preschoolers' theory of mind
SO NEUROPSYCHOLOGIA
LA English
DT Article
DE Theory of mind; Executive functioning; Dopamine; Developmental
neuropsychology; Social neuroscience
ID SPONTANEOUS EYEBLINK RATE; FALSE-BELIEF; BLINK RATE; EXECUTIVE FUNCTION;
PREFRONTAL CORTEX; COGNITIVE CONTROL; CHILDREN; SCHIZOPHRENIA; DISORDER;
BRAIN
AB Representational theory of mind (RTM) development follows a universal developmental timetable whereby major advances in reasoning about mental representations occur between the ages of 3 and 5 years old. This progression appears to be only absent in the case of specific neurodevelopmental impairments, such as autism. Taken together, this suggests that neuromaturational factors may play a role in RTM development. Recent EEG work has shown that one neuromaturational factor pacing this universal developmental timetable is the functional maturation of medial prefrontal cortex. The neurotransmitter dopamine (DA) is thought to play a crucial role in typical frontal lobe development. Therefore, the goal of the present study was to investigate the role that DA may play in RIM development. Ninety-one 48-62-month olds were given a battery of RIM tasks along with EEG measurement. EEG recordings were analyzed for eyeblinks, a reliable indicator of DA functioning, and we calculated their average eyeblinks per minute (EBR). Regression analyses showed that EBR was associated with RIM after controlling for children's performance on a Stroop-like measure, language ability, gender, and age. These findings provide evidence that DA functioning is associated with RTM in the preschool years, and are discussed with respect to how DA might provide a mechanism that helps to account for both neurobiological and experiential factors that are known to affect the timetable of preschoolers' RIM development. (C) 2010 Elsevier Ltd. All rights reserved.
C1 [Sabbagh, Mark A.] Queens Univ, Dept Psychol, Kingston, ON K7L 3L3, Canada.
[Bowman, Lindsay C.] Univ Michigan, Ann Arbor, MI 48109 USA.
RP Sabbagh, MA (reprint author), Queens Univ, Dept Psychol, 62 Arch St, Kingston, ON K7L 3L3, Canada.
EM sabbagh@queensu.ca
FU Natural Sciences and Engineering Research Council of Canada (NSERC)
FX This research was supported by a Alexander Graham Bell Graduate
Fellowship from the Natural Sciences and Engineering Research Council of
Canada (NSERC) to Lackner, and by an NSERC Discovery Grant to Sabbagh.
We thank Lyndsay Evraire, Jennie Ito, and Tracy Ma for their assistance
with data collection and coding. We also thank Rick Beninger and Tom
Hollenstein for helpful discussions of the work.
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NR 57
TC 14
Z9 16
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0028-3932
J9 NEUROPSYCHOLOGIA
JI Neuropsychologia
PD MAY
PY 2010
VL 48
IS 6
BP 1767
EP 1774
DI 10.1016/j.neuropsychologia.2010.02.027
PG 8
WC Behavioral Sciences; Neurosciences; Psychology, Experimental
SC Behavioral Sciences; Neurosciences & Neurology; Psychology
GA 604FE
UT WOS:000278261900027
PM 20206642
ER
PT J
AU Zannolli, R
Buoni, S
Tassini, M
De Nicola, A
Betti, G
De Felice, C
Orsi, A
Varetti, MC
Ferrara, F
Messina, M
Giannini, C
Mohn, A
Chiarelli, F
Liberati, M
Strambi, M
Funghini, S
Vivi, A
Wevers, RA
Hayek, J
AF Zannolli, Raffaella
Buoni, Sabrina
Tassini, Maria
De Nicola, Anna
Betti, Gianni
De Felice, Claudio
Orsi, Alessandra
Varetti, Maria Concetta
Ferrara, Francesco
Messina, Mario
Giannini, Cosimo
Mohn, Angelika
Chiarelli, Francesco
Liberati, Marco
Strambi, Mirella
Funghini, Silvia
Vivi, Antonio
Wevers, Ron A.
Hayek, Joseph
TI Silent increase of urinary ethylmalonic acid is an indicator of
nonspecific brain dysfunction
SO NMR IN BIOMEDICINE
LA English
DT Article
DE autism; CNS dysfunction; ethylmalonic acid; excretion; mental delay;
proton nuclear magnetic resonance; spectroscopy; urine
ID DEHYDROGENASE SCAD DEFICIENCY; CHAIN ACYL-COENZYME; DISORDERS;
METABOLISM; CHILDREN; CRITERIA; DISEASE; GENE
AB Our aim was to compare urinary ethylmalonic acid (EMA) levels in subjects who had no apparent clinical reason to have increased levels of this substance but were suffering from non-specific CNS impairment, and healthy controls. Urinary EMA concentrations detected by (1)H-NMR spectroscopy were studied in 130 subjects with CNS impairment of unknown origin (with no definite diagnosis, no specific symptoms or signs, and normal common biochemical and metabolic screening results) and 130 age- and sex-matched healthy subjects. EMA levels exceeding two standard deviations (SD) above normal (i.e. 8.1 mmol/molCn) were found in a subgroup of CNS-impaired patients and healthy controls. EMA levels exceeding 2 SD above normal were fourfold prevalent in the urine of patients with non-specific CNS impairment compared to from the EMA levels in healthy controls. Moreover, we found that the level exceeding > 8.1 mmol/molCn (i.e. > + 2 SD) had sufficient discrimination accuracy in identifying subjects with non-specific CNS impairment; the level exceeding 12 mmol/molCn (i.e. > + 6 SD) reaches suitable accuracy (i.e. 100% specificity and 78.6% sensitivity). These observations are of importance, as we found that subtle increases in urinary EMA levels are frequent in patients with non-specific CNS impairment. The reasons for this association remain unknown. Copyright (C) 2010 John Wiley & Sons, Ltd.
C1 [Zannolli, Raffaella; Buoni, Sabrina; De Nicola, Anna; Orsi, Alessandra; Strambi, Mirella; Hayek, Joseph] Azienda Osped Univ Senese, Child Neurol & Psychiat Unit, Policlin Le Scotte, Siena, Italy.
[Tassini, Maria; Wevers, Ron A.] Radboud Univ Nijmegen, Med Ctr, Lab Pediat & Neurol, NL-6525 ED Nijmegen, Netherlands.
[Tassini, Maria; Vivi, Antonio] Univ Siena, NMR Ctr, I-53100 Siena, Italy.
[Betti, Gianni] Univ Siena, Dept Quantitat Methods, I-53100 Siena, Italy.
[De Felice, Claudio] Azienda Osped Univ Senese, Neonatal Intens Care Unit, Policlin Le Scotte, Siena, Italy.
[Varetti, Maria Concetta; Ferrara, Francesco; Messina, Mario] Azienda Osped Univ Senese, Dept Pediat Surg, Policlin Le Scotte, Siena, Italy.
[Giannini, Cosimo; Mohn, Angelika; Chiarelli, Francesco] Univ G dAnnunzio, Dept Pediat, Chieti, Italy.
[Liberati, Marco] Univ G dAnnunzio, Dept Obstet & Gynecol, Chieti, Italy.
[Funghini, Silvia] Meyer Hosp, Azienda Osped Univ, Florence, Italy.
RP Zannolli, R (reprint author), Azienda Osped Univ Senese, Child Neurol & Psychiat Unit, Policlin Le Scotte, Siena, Italy.
EM zannolli@unisi.it
RI Wevers, Ron/H-8116-2014
OI Wevers, Ron/0000-0003-2278-9746
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PI CHICHESTER
PA THE ATRIUM, SOUTHERN GATE, CHICHESTER PO19 8SQ, W SUSSEX, ENGLAND
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JI NMR Biomed.
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IS 4
BP 353
EP 358
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SC Biophysics; Radiology, Nuclear Medicine & Medical Imaging; Spectroscopy
GA 594HA
UT WOS:000277525800003
PM 20187168
ER
PT J
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LA English
DT Article
DE AD/HD; Autism; Child psychiatry; Screening; Validity
ID ASPERGER-SYNDROME; DISORDER; DIAGNOSES; TWIN; PSYCHOPATHOLOGY;
POPULATION; PREVALENCE; DEPRESSION; PHENOTYPE; ANXIETY
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NR 90
TC 14
Z9 14
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0887-8994
J9 PEDIATR NEUROL
JI Pediatr. Neurol.
PD MAY
PY 2010
VL 42
IS 5
BP 309
EP 314
DI 10.1016/j.pediatrneurol.2009.10.009
PG 6
WC Clinical Neurology; Pediatrics
SC Neurosciences & Neurology; Pediatrics
GA 591SR
UT WOS:000277325000001
PM 20399382
ER
PT J
AU McCabe, ERB
AF McCabe, Edward R. B.
TI Nanopediatrics: Enabling Personalized Medicine for Children
SO PEDIATRIC RESEARCH
LA English
DT Review
ID RARE GENETIC-DISEASES; COPY-NUMBER-VARIATION; VAULT NANOPARTICLES;
GENOMIC MEDICINE; DRUG-DELIVERY; SYSTEM; AUTISM; NANOMEDICINE;
NANOCAPSULES; MUTATIONS
AB The topic of the special series of reviews in this issue will be nanobiology and nanomedicine, with a focus on the impact of nanotechnology on children and their health; hence, the title of this collection and this introduction, Nanopediatrics: Enabling Personalized Medicine for Children. We will address what is meant when we discuss these nanodisciplines and why we developed a NanoPediatries Program at University of California, Los Angeles. We will consider the implications of these nanodisciplines for individuals and society. The nature of research, diagnosis, and screening in nanomedicine and nanopediatrics will be illustrated by selected projects in nanodiagnostics and nanotherapeutics by our group and our collaborators, and the combined use of diagnostics and therapeutics in a single nanodevice referred to as "theranostics." We will conclude this introductory review with a summary of the reasons for developing the discipline of nanopediatrics. (Pediatr Res 67: 453-457, 2010)
C1 [McCabe, Edward R. B.] Univ Calif Los Angeles, David Geffen Sch Med, Dept Pediat, Los Angeles, CA 90095 USA.
[McCabe, Edward R. B.] Univ Calif Los Angeles, David Geffen Sch Med, Dept Human Genet, Los Angeles, CA 90095 USA.
[McCabe, Edward R. B.] Univ Calif Los Angeles, Henry Samueli Sch Engn & Appl Sci, Dept Bioengn, Los Angeles, CA 90095 USA.
RP McCabe, ERB (reprint author), Univ Calif Los Angeles, Mattel Childrens Hosp, 10833 Conte Ave,22-412 MDCC, Los Angeles, CA 90095 USA.
EM emccabe@mednet.ucla.edu
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NR 49
TC 4
Z9 4
PU INT PEDIATRIC RESEARCH FOUNDATION, INC
PI BALTIMORE
PA 351 W CAMDEN ST, BALTIMORE, MD 21201-2436 USA
SN 0031-3998
J9 PEDIATR RES
JI Pediatr. Res.
PD MAY
PY 2010
VL 67
IS 5
BP 453
EP 457
PG 5
WC Pediatrics
SC Pediatrics
GA 587DJ
UT WOS:000276968000001
PM 20118826
ER
PT J
AU Landgren, M
Svensson, L
Stromland, K
Gronlund, MA
AF Landgren, Magnus
Svensson, Leif
Stromland, Kerstin
Gronlund, Marita Andersson
TI Prenatal Alcohol Exposure and Neurodevelopmental Disorders in Children
Adopted From Eastern Europe
SO PEDIATRICS
LA English
DT Article
DE fetal alcohol syndrome; autism; attention-deficit/hyperactivity
disorder; developmental coordination disorder; adopted children; mental
retardation; microcephalus; ocular malformations
ID PRACTICAL CLINICAL APPROACH; FETAL ALCOHOL; SPECTRUM DISORDERS;
ATTENTION; ABNORMALITIES; DYSFUNCTION; PREVALENCE; DIAGNOSIS; DEFICITS;
SCHOOLS
AB OBJECTIVES: The purposes of this investigation were to determine the frequencies of and associations between different neurodevelopmental disorders and to study the potential lasting effects of alcohol on children adopted from eastern Europe.
METHODS: In a population-based, prospective, observational, multidisciplinary, cross-sectional, cohort study of 71 children adopted from eastern Europe, children were assessed 5 years after adoption, from pediatric, neuropsychological, and ophthalmologic perspectives.
RESULTS: Fetal alcohol spectrum disorders, that is, fetal alcohol syndrome (FAS), partial FAS, and alcohol-related neurodevelopmental disorders, were identified for 52% of children; FAS was found for 30%, partial FAS for 14%, and alcohol-related neurodevelopmental disorders for 9%. Alcohol-related birth defects were found for 11% of children, all of whom also were diagnosed as having FAS. Mental retardation or significant cognitive impairment was found for 23% of children, autism for 9%, attention-deficit/hyperactivity disorder for 51%, and developmental coordination disorder for 34%.
CONCLUSIONS: Fetal alcohol spectrum disorders and neurodevelopmental disorders were common in this long-term follow-up study of children adopted from orphanages in eastern Europe. Maternal alcohol consumption during pregnancy has long-lasting adverse effects, causing structural, behavioral, and cognitive damage despite a radically improved environment. Pediatrics 2010; 125: e1178-e1185
C1 [Landgren, Magnus; Svensson, Leif] Skaraborg Hosp, Dept Pediat, SE-54185 Skovde, Sweden.
[Stromland, Kerstin; Gronlund, Marita Andersson] Univ Gothenburg, Inst Neurosci & Physiol Ophthalmol, Sahlgrenska Acad, Gothenburg, Sweden.
RP Landgren, M (reprint author), Skaraborg Hosp, Dept Pediat, SE-54185 Skovde, Sweden.
EM magnus.landgren@vgregion.se
FU Research and Development of Region Vastra Gotaland; Skaraborg Hospital;
W & M Lundgrens Vetenskapsfond II; All-manna Barnhuset; Gothenburg
Medical Society
FX Grants were received from Research and Development of Region Vastra
Gotaland, the Institute of Skaraborg Research Fund at Skaraborg
Hospital, W & M Lundgrens Vetenskapsfond II, All-manna Barnhuset, and
the Gothenburg Medical Society.
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NR 37
TC 31
Z9 32
PU AMER ACAD PEDIATRICS
PI ELK GROVE VILLAGE
PA 141 NORTH-WEST POINT BLVD,, ELK GROVE VILLAGE, IL 60007-1098 USA
SN 0031-4005
J9 PEDIATRICS
JI Pediatrics
PD MAY
PY 2010
VL 125
IS 5
BP E1178
EP E1185
DI 10.1542/peds.2009-0712
PG 8
WC Pediatrics
SC Pediatrics
GA 590NI
UT WOS:000277232800053
PM 20385628
ER
PT J
AU Imielinski, M
Hakonarson, H
AF Imielinski, Marcin
Hakonarson, Hakon
TI Breaking new ground in inflammatory bowel disease genetics: genome-wide
association studies and beyond
SO PHARMACOGENOMICS
LA English
DT Editorial Material
ID COPY NUMBER VARIATION; ULCERATIVE-COLITIS; CROHNS-DISEASE;
SUSCEPTIBILITY LOCI; SEQUENCE VARIANTS; CONTRIBUTE; AUTOPHAGY; MULTIPLE;
AUTISM; IRGM
C1 [Imielinski, Marcin; Hakonarson, Hakon] Childrens Hosp Penn, Ctr Appl Genom, Philadelphia, PA 19104 USA.
[Hakonarson, Hakon] Childrens Hosp Penn, Div Human Genet, Philadelphia, PA 19104 USA.
[Hakonarson, Hakon] Univ Penn, Dept Pediat, Philadelphia, PA 19104 USA.
RP Hakonarson, H (reprint author), Childrens Hosp Penn, Ctr Appl Genom, Philadelphia, PA 19104 USA.
EM hakonarson@email.chop.edu
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NR 23
TC 6
Z9 6
PU FUTURE MEDICINE LTD
PI LONDON
PA UNITEC HOUSE, 3RD FLOOR, 2 ALBERT PLACE, FINCHLEY CENTRAL, LONDON, N3
1QB, ENGLAND
SN 1462-2416
J9 PHARMACOGENOMICS
JI Pharmacogenomics
PD MAY
PY 2010
VL 11
IS 5
BP 663
EP 665
DI 10.2217/PGS.10.56
PG 3
WC Pharmacology & Pharmacy
SC Pharmacology & Pharmacy
GA 591OI
UT WOS:000277310200013
PM 20415557
ER
PT J
AU Mefford, HC
Muhle, H
Ostertag, P
von Spiczak, S
Buysse, K
Baker, C
Franke, A
Malafosse, A
Genton, P
Thomas, P
Gurnett, CA
Schreiber, S
Bassuk, AG
Guipponi, M
Stephani, U
Helbig, I
Eichler, EE
AF Mefford, Heather C.
Muhle, Hiltrud
Ostertag, Philipp
von Spiczak, Sarah
Buysse, Karen
Baker, Carl
Franke, Andre
Malafosse, Alain
Genton, Pierre
Thomas, Pierre
Gurnett, Christina A.
Schreiber, Stefan
Bassuk, Alexander G.
Guipponi, Michel
Stephani, Ulrich
Helbig, Ingo
Eichler, Evan E.
TI Genome-Wide Copy Number Variation in Epilepsy: Novel Susceptibility Loci
in Idiopathic Generalized and Focal Epilepsies
SO PLOS GENETICS
LA English
DT Article
ID RARE CHROMOSOMAL DELETIONS; SEVERE MYOCLONIC EPILEPSY; AUTISM SPECTRUM
DISORDER; PRADER-WILLI-SYNDROME; MENTAL-RETARDATION; RECURRENT
REARRANGEMENTS; 15Q13.3 MICRODELETIONS; CLINICAL SPECTRUM; INCREASE
RISK; ARRAY CGH
AB Epilepsy is one of the most common neurological disorders in humans with a prevalence of 1% and a lifetime incidence of 3%. Several genes have been identified in rare autosomal dominant and severe sporadic forms of epilepsy, but the genetic cause is unknown in the vast majority of cases. Copy number variants (CNVs) are known to play an important role in the genetic etiology of many neurodevelopmental disorders, including intellectual disability (ID), autism, and schizophrenia. Genome-wide studies of copy number variation in epilepsy have not been performed. We have applied whole-genome oligonucleotide array comparative genomic hybridization to a cohort of 517 individuals with various idiopathic, non-lesional epilepsies. We detected one or more rare genic CNVs in 8.9% of affected individuals that are not present in 2,493 controls; five individuals had two rare CNVs. We identified CNVs in genes previously implicated in other neurodevelopmental disorders, including two deletions in AUTS2 and one deletion in CNTNAP2. Therefore, our findings indicate that rare CNVs are likely to contribute to a broad range of generalized and focal epilepsies. In addition, we find that 2.9% of patients carry deletions at 15q11.2, 15q13.3, or 16p13.11, genomic hotspots previously associated with ID, autism, or schizophrenia. In summary, our findings suggest common etiological factors for seemingly diverse diseases such as ID, autism, schizophrenia, and epilepsy.
C1 [Mefford, Heather C.] Univ Washington, Dept Pediat, Seattle, WA 98195 USA.
[Mefford, Heather C.; Baker, Carl; Eichler, Evan E.] Univ Washington, Dept Genome Sci, Seattle, WA 98195 USA.
[Muhle, Hiltrud; Ostertag, Philipp; von Spiczak, Sarah; Stephani, Ulrich; Helbig, Ingo] Univ Kiel, Dept Neuropediat, Kiel, Germany.
[Muhle, Hiltrud; Ostertag, Philipp; von Spiczak, Sarah; Stephani, Ulrich; Helbig, Ingo] Univ Med Ctr Schleswig Holstein, Kiel, Germany.
[Buysse, Karen] Ghent Univ Hosp, Ctr Med Genet, Ghent, Belgium.
[Franke, Andre; Schreiber, Stefan] Univ Kiel, Inst Clin Mol Biol, Kiel, Germany.
[Malafosse, Alain; Guipponi, Michel] Univ Geneva, Sch Med, Dept Genet Med & Dev, CH-1211 Geneva, Switzerland.
[Malafosse, Alain; Guipponi, Michel] Univ Hosp Geneva, Geneva, Switzerland.
[Genton, Pierre] Ctr St Paul Hop Henri Gastaut, Marseilles, France.
[Thomas, Pierre] Hop Louis Pasteur, Unite Fonct EEG Epileptol, F-06002 Nice, France.
[Thomas, Pierre] Hop Louis Pasteur, Serv Neurol, F-06002 Nice, France.
[Gurnett, Christina A.] Washington Univ, Dept Neurol, St Louis, MO USA.
[Bassuk, Alexander G.] Univ Iowa, Dept Pediat, Iowa City, IA 52242 USA.
[Eichler, Evan E.] Univ Washington, Howard Hughes Med Inst, Seattle, WA 98195 USA.
RP Mefford, HC (reprint author), Univ Washington, Dept Pediat, Seattle, WA 98195 USA.
EM hmefford@u.washington.edu
RI Schreiber, Stefan/B-6748-2008; Franke, Andre/B-2151-2010; Stephani,
Ulrich/D-1004-2010; Helbig, Ingo/A-5544-2009
OI Schreiber, Stefan/0000-0003-2254-7771; Franke,
Andre/0000-0003-1530-5811;
FU U.S. National Institutes of Health [HD043569, HD043376, NS064159];
Burroughs Wellcome Fund
FX This work is supported, in part, by U.S. National Institutes of Health
grants HD043569 to EEE, HD043376 to HCM, and NS064159 to AGB. HCM holds
a Career Award for Medical Scientists from the Burroughs Wellcome Fund.
EEE is an investigator of the Howard Hughes Medical Institute. The
funders had no role in study design, data collection and analysis,
decision to publish, or preparation of the manuscript.
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NR 61
TC 181
Z9 184
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA
SN 1553-7390
J9 PLOS GENET
JI PLoS Genet.
PD MAY
PY 2010
VL 6
IS 5
AR e1000962
DI 10.1371/journal.pgen.1000962
PG 9
WC Genetics & Heredity
SC Genetics & Heredity
GA 608BU
UT WOS:000278557300032
PM 20502679
ER
PT J
AU Belinchon Carmona, M
Munoz, LB
Garcia de Andres, E
Biggi, JF
de la Paz, MP
AF Belinchon Carmona, Mercedes
Boada Munoz, Leticia
Garcia de Andres, Esther
Fuentes Biggi, Joaquin
Posada de la Paz, Manuel
TI Trends in studies on autism in Spain: Publications and authorship
networks (1974-2007)
SO PSICOTHEMA
LA Spanish
DT Article
ID DEVELOPMENTAL-DISABILITIES; PRACTICE GUIDELINES; SPECTRUM DISORDERS;
COLLABORATION; PSYCHOLOGY; JOURNALS
AB Trends in studies on autism in Spain: Publications and authorship networks (1974-2007). All the papers on autism published in journals by Spanish authors until 2007 were reviewed in order to identify changes and trends in studies, journals and authorship networks. A total of 567 works were analyzed. Results showed a continuous increase in the total number of publications and collaborative works (especially from 1999 onwards), as well as coincidence of the general framework of papers with the guidelines for research and treatment on autism that were published in the Anglo-Saxon arena for the same period. Some weak points were also identified, such as the low proportion of empirical and funded studies, low impact of the journals, and low author continuity, which have also been noted for other domains of research in Spain. We conclude that psychological and biomedical research on autism is currently a growing field in our country. However, important changes are needed, both in the way the authors conduct and communicate their studies, and in the commitment of some institutions (specially, universities and parent advocacy groups). Lastly, some proposals are suggested to improve the scientific quality of future studies and their usefulness for people with autism.
C1 [Belinchon Carmona, Mercedes] Univ Autonoma Madrid, Fac Psicol, Inst Salud Carlos III, E-28049 Madrid, Spain.
[Fuentes Biggi, Joaquin] Univ Autonoma Madrid, Clin Gipuzkoa, E-28049 Madrid, Spain.
RP Belinchon Carmona, M (reprint author), Univ Autonoma Madrid, Fac Psicol, Inst Salud Carlos III, E-28049 Madrid, Spain.
EM mercedes.belinchon@uam.es
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NR 41
TC 0
Z9 0
PU COLEGIO OFICIAL DE PSICOLOGOS DE ASTURIAS
PI OVIEDO
PA ILDEFONSO S. DEL RIO, 4-1 B, 33001 OVIEDO, SPAIN
SN 0214-9915
EI 1886-144X
J9 PSICOTHEMA
JI Psicothema
PD MAY
PY 2010
VL 22
IS 2
BP 242
EP 249
PG 8
WC Psychology, Multidisciplinary
SC Psychology
GA 586YP
UT WOS:000276952200011
PM 20423628
ER
PT J
AU Gepner, B
Laine, F
Tardif, C
AF Gepner, B.
Laine, F.
Tardif, C.
TI Autistic constellation disorders: too rapid world for disconnected
brain?
SO PSN-PSYCHIATRIE SCIENCES HUMAINES NEUROSCIENCES
LA French
DT Article
DE Autism; Temporal processing; Sensory stimuli; Connectivity; Speed;
Slowing down
ID SPECTRUM DISORDERS; FUNCTIONAL CONNECTIVITY; MOTION; CHILDREN;
PERCEPTION; SYNCHRONIZATION; INTEGRATION; DIRECTIONS; DEFICIT
AB In the continuation of the concepts of E-Motion mis-sight and Temporo-Spatial Processing Disorders (TSPD) of multi-sensory stimuli, we carry on our developmental theory of autism. We first remind that TSPDs consist in difficulties and peculiarities perceiving and integrating online the temporal and spatial characteritics of the incoming sensory events in the visual, auditory and proprioceptive modalities. Via the clinical manifestations exhibited by a baby at risk for autism, some self reports of autistic adults, and several experimental results, we show how the TSPDs might be central for the main behavioral, imitative, sensory-motor and cognitive disorders of at least some autistic persons. Then we present a new concept, the Multi-system Brain Disconnectivity-Dissynchrony (MBD), which represents the various degrees of under- or over- functional connectivity and hypo- or hyper-synchronization between numerous brain regions, and show that MBD might consitute the neurophysiological basis of TSPDs. We finally present the therapeutical applications and clinical perspectives that emerge from our approach, in particular via slowing down the environmental visual and auditory signals.
C1 [Gepner, B.] Univ Aix Marseille 1, CNRS, UMR 6057, Lab Parole & Langage, F-13064 Aix En Provence, France.
[Gepner, B.] Ctr Hosp Montperrin, F-13617 Aix En Provence, France.
[Laine, F.] McGill Univ, Fac Educ & Psychopedagog, Montreal, PQ, Canada.
[Tardif, C.] Univ Aix Marseille 1, Ctr PsyCle, EA 3273, UFR Psychol, F-13621 Aix En Provence, France.
RP Gepner, B (reprint author), Univ Aix Marseille 1, CNRS, UMR 6057, Lab Parole & Langage, 5 Ave Pasteur, F-13064 Aix En Provence, France.
EM bruno.gepner@univ-provence.fr
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NR 42
TC 1
Z9 1
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1639-8319
J9 PSN-PSYCHIATR SCI HU
JI PSN-Psychiatr. Sci. Hum. Neurosc.
PD MAY
PY 2010
VL 8
IS 2
BP 67
EP 76
DI 10.1007/s11836-010-0126-y
PG 10
WC Neurosciences
SC Neurosciences & Neurology
GA 602EM
UT WOS:000278121300003
ER
PT J
AU Neidert, PL
Dozier, CL
Iwata, BA
Hafen, M
AF Neidert, Pamela L.
Dozier, Claudia L.
Iwata, Brian A.
Hafen, Megan
TI Behavior Analysis in Intellectual and Developmental Disabilities
SO PSYCHOLOGICAL SERVICES
LA English
DT Article
DE functional analysis; function-based treatment; behavior disorders;
adaptive behavior
ID FUNCTIONAL-ANALYSIS; ESTABLISHING OPERATIONS; MENTAL-RETARDATION;
TEACHING-CHILDREN; RETARDED-CHILDREN; STIMULUS-CONTROL; SKILLS; AUTISM;
REINFORCEMENT; MANAGEMENT
AB Individuals with intellectual and developmental disabilities (IDD) have deficits in adaptive behavior, slow rates of learning, and behavior disorders that interfere with learning or place them or others at risk. Since the 1960s, researchers and clinicians in the field of applied behavior analysis have used methods based on principles of learning to increase adaptive behavior and decrease the occurrence of behavior disorders of individuals with IDD. This article provides an overview of assessment and treatment strategies used in behavior analysis to effect positive changes in the quality of life for individuals with IDD and presents an illustrative case study.
C1 [Neidert, Pamela L.; Dozier, Claudia L.; Hafen, Megan] Univ Kansas, Dept Appl Behav Sci, Lawrence, KS 66045 USA.
[Iwata, Brian A.] Univ Florida, Dept Psychol, Gainesville, FL 32611 USA.
RP Neidert, PL (reprint author), Univ Kansas, Dept Appl Behav Sci, Lawrence, KS 66045 USA.
EM pneidert@ku.edu
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NR 58
TC 11
Z9 11
PU AMER PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA
SN 1541-1559
J9 PSYCHOL SERV
JI Psychol. Serv.
PD MAY
PY 2010
VL 7
IS 2
BP 103
EP 113
DI 10.1037/a0018791
PG 11
WC Psychology, Clinical
SC Psychology
GA 789QF
UT WOS:000292529700005
ER
PT J
AU Baines, C
AF Baines, Chris
TI Autism in the Early Years: A Practical Guide, 2nd edition
SO PSYCHOLOGIST
LA English
DT Book Review
CR CUMINE V, 2010, AUTISM EARLY YEARS A
NR 1
TC 0
Z9 0
PU BRITISH PSYCHOLOGICAL SOC
PI LEICESTER
PA ST ANDREWS HOUSE, 48 PRINCESS RD EAST, LEICESTER LE1 7DR, LEICS, ENGLAND
SN 0952-8229
J9 PSYCHOLOGIST
JI Psychologist
PD MAY
PY 2010
VL 23
IS 5
BP 403
EP 403
PG 1
WC Psychology, Multidisciplinary
SC Psychology
GA 599HZ
UT WOS:000277903300031
ER
PT J
AU Fernell, E
Gillberg, C
AF Fernell, Elisabeth
Gillberg, Christopher
TI Autism spectrum disorder diagnoses in Stockholm preschoolers
SO RESEARCH IN DEVELOPMENTAL DISABILITIES
LA English
DT Article
DE Autism spectrum disorder; Developmental disorders; Prevalence;
Assessment
ID PERVASIVE DEVELOPMENTAL DISORDERS; PREVALENCE; CHILDREN; COMMUNICATION;
SUBSTITUTION; EPIDEMIOLOGY; DEFICITS; EPILEPSY
AB The aims of this study were to estimate prevalence rates of children with autism spectrum disorder (ASD) diagnoses in a cohort of 6-year-old children with birth year 2002, referred to the Autism Centre for Young Children, serving the whole of Stockholm county and on the basis of the available data discuss clinical aspects of assessment, habilitation and follow-up.
Records of 142 of a total of 147 (123 boys and 24 girls) identified children with ASD diagnoses were scrutinised with respect to type of diagnosis, cognitive level, other developmental disorders and medical/neurological disorders. The overall prevalence of such disorders was 6.2/1000(95% confidence interval 5.2-7.2/1000). The rates of learning disability/mental retardation, developmental delay without a specified cognitive level and normal intelligence constituted about one third, respectively. AS and atypical autism tended to be diagnosed more often at age 5-6 years while AD with learning disability/mental retardation was more often diagnosed at age 3-4 years. The awareness of ASDs has resulted in increasing numbers of children being diagnosed at young ages. We conclude that it is important to take into account these children's broader developmental profiles, need for repeated assessment of cognitive functions and follow-up over time and also the requirement for medical/neurological consideration and work-up. (C) 2010 Elsevier Ltd. All rights reserved.
C1 [Fernell, Elisabeth] Autism Ctr Young Children Handicap & Habilitat, S-10462 Stockholm, Sweden.
[Fernell, Elisabeth] Karolinska Univ Hosp, Stockholm, Sweden.
[Fernell, Elisabeth] FoU Ctr Skovde, Skovde, Sweden.
[Gillberg, Christopher] Sahlgrens Acad, Inst Neurosci & Physiol Child & Adolescent Psychi, Gothenburg, Sweden.
RP Fernell, E (reprint author), Autism Ctr Young Children Handicap & Habilitat, Box 170 56, S-10462 Stockholm, Sweden.
EM elisabeth.fernell@karolinska.se
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NR 25
TC 51
Z9 52
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0891-4222
J9 RES DEV DISABIL
JI Res. Dev. Disabil.
PD MAY-JUN
PY 2010
VL 31
IS 3
BP 680
EP 685
DI 10.1016/j.ridd.2010.01.007
PG 6
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA 583GT
UT WOS:000276662400007
PM 20149593
ER
PT J
AU Gennaro, L
Russo, L
Losito, L
Zaccaria, A
De Rinaldis, M
Trabacca, A
AF Gennaro, Leonarda
Russo, Luigi
Losito, Luciana
Zaccaria, Alessia
De Rinaldis, Marta
Trabacca, Antonio
TI Movement disorders in a twins pair: A casual expression or genetic
determination?
SO RESEARCH IN DEVELOPMENTAL DISABILITIES
LA English
DT Article
DE Movement disorders; Stereotypy; Children; Mental retardation;
Heritability; Twin method
ID SELF-INJURIOUS-BEHAVIOR; MONOZYGOTIC TWINS; MOTOR STEREOTYPIES;
BRAIN-DEVELOPMENT; RETT SYNDROME; CHILDREN; AUTISM; CONNECTIVITY;
SEVERITY
AB A twin study is an excellent means of assessing the contribution of heritability to motor behaviour. We present a movement video-analysis of a monozygotic twins pair with a motor repertoire which is almost totally constituted by persistent and subcontinuous motor stereotypies.
Purpose: The specific aim of this study is to verify the heritable quantum of motor behaviour and to determine which among the motor patterns we analysed are more likely to be conditioned by inheritance.
Methods: Stereotyped movements were videotaped in two standardized sessions: at rest and in relation to preordained sensory stimulations. We estimated the concordance index (Cl) between the observers to evaluate the reliability of the observations. The validity was accepted as being Cl > 0.80.
Results: The results showed a very high concordance rate (>90%) for all the stereotypies analysed. An almost superimposable trend of the stereotyped movements was found both at rest and in relation to the sensory stimulations.
Conclusions: Such strong data suggest that genetic factors have a primary influence on all the movement disorders analysed. This study contributes to a better understanding of the complex relationships between genes and functions. (C) 2010 Elsevier Ltd. All rights reserved.
C1 [Gennaro, Leonarda; Russo, Luigi; Losito, Luciana; Zaccaria, Alessia; De Rinaldis, Marta; Trabacca, Antonio] La Nostra Famiglia Assoc, E Medea Sci Inst, IRCCS, Unit Neurorehabil Dev Neurol & Funct Rehabil 1, I-72017 Ostuni, Brindisi, Italy.
RP Trabacca, A (reprint author), La Nostra Famiglia Assoc, E Medea Sci Inst, IRCCS, Unit Neurorehabil Dev Neurol & Funct Rehabil 1, Via Colli 5-7, I-72017 Ostuni, Brindisi, Italy.
EM ANTONIO.TRABACCA@OS.LNF.IT
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NR 25
TC 1
Z9 1
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0891-4222
J9 RES DEV DISABIL
JI Res. Dev. Disabil.
PD MAY-JUN
PY 2010
VL 31
IS 3
BP 692
EP 697
DI 10.1016/j.ridd.2010.01.009
PG 6
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA 583GT
UT WOS:000276662400009
PM 20153949
ER
PT J
AU Oeseburg, B
Jansen, DEMC
Dijkstra, GJ
Groothoff, JW
Reijneveld, SA
AF Oeseburg, B.
Jansen, D. E. M. C.
Dijkstra, G. J.
Groothoff, J. W.
Reijneveld, S. A.
TI Prevalence of chronic diseases in adolescents with intellectual
disability
SO RESEARCH IN DEVELOPMENTAL DISABILITIES
LA English
DT Article
DE Mental retardation; Chronic diseases; Adolescents; Epidemiology
ID SEVERE MENTAL-RETARDATION; PSYCHIATRIC-DISORDERS; DEVELOPMENTAL DELAY;
VISUAL DYSFUNCTIONS; OCULAR DISORDERS; HEALTH-PROBLEMS; BIRTH-DEFECTS;
YOUNG-PEOPLE; CHILDREN; AUTISM
AB Valid community-based data on the prevalence of chronic diseases in adolescents (12-18 years) with intellectual disability (ID-adolescents) are scarce. The aim of this study was to assess the prevalence rates and the nature of chronic diseases in a population of ID-adolescents and to compare them with the rates among adolescents in the general population. Therefore, we obtained data on 1083 ID-adolescents attending secondary schools, day care centers or living in residential centers fully covering one region of the Netherlands. Parents of the adolescents completed a questionnaire about the occurrence of chronic diseases in their child during the previous 12 months and about background characteristics. The questionnaire was derived from the Dutch National Permanent Survey on Living Conditions questionnaire periodically administered in a representative population sample (n approximate to 10,000). Prevalence rates of chronic diseases in ID-adolescents were compared with those in adolescents in the Dutch general population. Among ID-adolescents, high prevalence rates of a wide range of chronic diseases were found. The five most prevalent were: ADHD (21.1%), PDD-NOS (14.0%), dyslexia (13.9%), migraine or chronic headache (12.7%), and autistic disorder (10.9%). These prevalence rates were all higher (p<0.05) than among adolescents in the general population. Of all ID-adolescents, 62.9% was reported to have at least one chronic disease. The burden of chronic diseases among ID-adolescents is very high, showing a high need for adequate care. These high prevalence rates should alert policymakers and clinicians regarding the widespread of chronic diseases among ID-adolescents. (C) 2010 Elsevier Ltd. All rights reserved.
C1 [Oeseburg, B.; Jansen, D. E. M. C.; Dijkstra, G. J.; Groothoff, J. W.; Reijneveld, S. A.] Univ Groningen, Dept Hlth Sci, Univ Med Ctr Groningen, NL-9700 RB Groningen, Netherlands.
[Oeseburg, B.; Jansen, D. E. M. C.; Dijkstra, G. J.; Groothoff, J. W.; Reijneveld, S. A.] Univ Groningen, Grad Sch Hlth Res, Univ Med Ctr Groningen, NL-9700 RB Groningen, Netherlands.
[Oeseburg, B.] Univ Med Ctr Groningen, Wenckebach Inst, Sch Nursing & Hlth, NL-9713 AV Groningen, Netherlands.
[Jansen, D. E. M. C.] Univ Groningen, Dept Sociol, Fac Behav & Social Sci, NL-9700 RB Groningen, Netherlands.
RP Oeseburg, B (reprint author), Univ Groningen, Dept Hlth Sci, Univ Med Ctr Groningen, POB 30-001, NL-9700 RB Groningen, Netherlands.
EM b.oeseburg@med.umcg.nl
RI Jansen, Danielle/E-9281-2013
OI Jansen, Danielle/0000-0002-2654-1038
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NR 55
TC 7
Z9 7
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0891-4222
J9 RES DEV DISABIL
JI Res. Dev. Disabil.
PD MAY-JUN
PY 2010
VL 31
IS 3
BP 698
EP 704
DI 10.1016/j.ridd.2010.01.011
PG 7
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA 583GT
UT WOS:000276662400010
PM 20188511
ER
PT J
AU Bhaumik, S
Tyrer, F
Barrett, M
Tin, N
McGrother, CW
Kiani, R
AF Bhaumik, Sabyasachi
Tyrer, Freya
Barrett, Mary
Tin, Nyunt
McGrother, Catherine W.
Kiani, Reza
TI The relationship between carers' report of autistic traits and clinical
diagnoses of autism spectrum disorders in adults with intellectual
disability
SO RESEARCH IN DEVELOPMENTAL DISABILITIES
LA English
DT Article
DE Autistic traits; Autism spectrum disorders; Autism; Asperger syndrome;
Intellectual disability; Learning disability
ID PERVASIVE DEVELOPMENTAL DISORDERS; PSYCHIATRIC-DISORDERS;
LEARNING-DISABILITIES; PREVALENCE; CHILDREN; PEOPLE; HARMONIZATION;
EPIDEMIOLOGY; ADOLESCENTS; POPULATION
AB It is often difficult to determine the triad of impairments and whether autistic features are the consequence of intellectual impairment or autism spectrum disorders in people with intellectual disability (ID). The aim of the current study was to investigate the relationship between carer-reported autistic traits and independent diagnoses of autism spectrum disorders (ASD). Data were collected on carers' subjective report of autistic traits and clinical diagnoses of ASD. Of 1145 adults with ID identified, 220 (19%) individuals had a diagnosis of ASD, and 778 (68%) individuals had at least one autistic trait. Optimal sensitivity and specificity were achieved with two or more autistic traits (sensitivity 63%; specificity 79%) and the positive predictive value increased substantially as the number of autistic traits increased. However, a significant proportion of individuals with ID who did not have a diagnosis of ASD also displayed autistic traits. Our findings suggest that in the absence of other measures, the presence of autistic traits can serve as a useful proxy measure for ASD in research (and/or clinical settings). However, although information on autistic traits may help healthcare practitioners to identify people with possible ASD, it cannot be used alone to make a formal diagnosis. (C) 2010 Elsevier Ltd. All rights reserved.
C1 [Tyrer, Freya; McGrother, Catherine W.] Univ Leicester, Dept Hlth Sci, Leicester LE1 6TP, Leics, England.
[Bhaumik, Sabyasachi; Barrett, Mary; Tin, Nyunt; Kiani, Reza] Leicestershire Partnership NHS Trust, Leicestershire Learning Disabil Serv, Leicester, Leics, England.
RP Tyrer, F (reprint author), Univ Leicester, Dept Hlth Sci, 22-28 Princess Rd W, Leicester LE1 6TP, Leics, England.
EM fct2@le.ac.uk
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NR 41
TC 9
Z9 9
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0891-4222
J9 RES DEV DISABIL
JI Res. Dev. Disabil.
PD MAY-JUN
PY 2010
VL 31
IS 3
BP 705
EP 712
DI 10.1016/j.ridd.2010.01.012
PG 8
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA 583GT
UT WOS:000276662400011
PM 20188512
ER
PT J
AU Kirby, A
Woodward, A
Jackson, S
Wang, Y
Crawford, MA
AF Kirby, A.
Woodward, A.
Jackson, S.
Wang, Y.
Crawford, M. A.
TI Childrens' learning and behaviour and the association with cheek cell
polyunsaturated fatty acid levels
SO RESEARCH IN DEVELOPMENTAL DISABILITIES
LA English
DT Article
DE Omega-3; Children; Behaviour; Cognition; Cheek cells
ID DEFICIT-HYPERACTIVITY-DISORDER; ATTENTION-DEFICIT/HYPERACTIVITY
DISORDER; DOCOSAHEXAENOIC ACID; PRESCHOOL-CHILDREN; AUTISTIC SPECTRUM;
CONTROLLED-TRIAL; MOTOR-SKILLS; SUPPLEMENTATION; CHILDHOOD; SYMPTOMS
AB Increasing interest in the role of omega-3 fatty acids in relation to neurodevelopmental disorders (e.g. ADHD, dyslexia, autism) has occurred as a consequence of some international studies highlighting this link. In particular, some studies have shown that children with ADHD may have lower concentrations of polyunsaturated fatty acids (PUFAs), particularly omega-3, in their red blood cells and plasma, and that supplementation with omega-3 fatty acids may alleviate behavioural symptoms in this population. However, in order to compare levels it seems appropriate to establish fatty acid levels in a mainstream school aged population and if levels relate to learning and behaviour. To date no study has established this. For this study, cheek cell samples from 411 typically developing school children were collected and analysed for PUFA content, in order to establish the range in this population. In addition, measures of general classroom attention and behaviour were assessed in these children by teachers and parents. Cognitive performance tests were also administered in order to explore whether an association between behaviour and/or cognitive performance and PUFA levels exists. Relationships between PUFA levels and socio-economic status were also explored. Measures of reading, spelling and intelligence did not show any association with PUFA levels, but some associations were noted with the level of omega-3 fatty acids and teacher and parental reports of behaviour, with some evidence that higher omega-3 levels were associated with decreased levels of inattention, hyperactivity, emotional and conduct difficulties and increased levels of prosocial behaviour. These findings are discussed in relation to previous findings from omega-3 supplementation studies with children. (C) 2010 Elsevier Ltd. All rights reserved.
C1 [Kirby, A.; Woodward, A.; Jackson, S.] Univ Wales, Dyscovery Ctr, Newport NP20 5DA, Wales.
[Wang, Y.; Crawford, M. A.] London Metropolitan Univ, Inst Brain Chem & Human Nutr, London N7 8DB, England.
RP Jackson, S (reprint author), Univ Wales, Dyscovery Ctr, Allt Yr Yn Campus, Newport NP20 5DA, Wales.
EM sarah.jackson@newport.ac.uk
CR [Anonymous], BMI PERC CALC CHILD
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NR 46
TC 16
Z9 16
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0891-4222
J9 RES DEV DISABIL
JI Res. Dev. Disabil.
PD MAY-JUN
PY 2010
VL 31
IS 3
BP 731
EP 742
DI 10.1016/j.ridd.2010.01.015
PG 12
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA 583GT
UT WOS:000276662400014
PM 20172688
ER
PT J
AU Smith, KRM
Matson, JL
AF Smith, Kimberly R. M.
Matson, Johnny L.
TI Psychopathology: Differences among adults with intellectually disabled,
comorbid autism spectrum disorders and epilepsy
SO RESEARCH IN DEVELOPMENTAL DISABILITIES
LA English
DT Article
DE Psychopathology; Assessment; Intellectual disability; Autism; Epilepsy
ID MENTAL-RETARDATION; PSYCHIATRIC-DISORDERS; DUAL DIAGNOSIS; DISABILITY;
PEOPLE; PREVALENCE; DEPRESSION; BEHAVIOR
AB The goal of this study was to systematically examine group differences among adults with intellectual disabilities (ID), comorbid autism spectrum disorders (ASD), and epilepsy through a detailed exploration of the characteristics that these disorders present in the area of psychopathology. Previous studies indicating that individuals with ID have comorbid ASD and epilepsy tend to stop short of addressing these disorders' impact on the full range of psychosocial issues, particularly in adult samples. Assessment of psychopathology was made with the ASD-comorbidity-adult version (ASD-CA). One hundred participants, with ID held constant, were matched and compared across four equal groups comprising 25 participants with ID, 25 participants with epilepsy, 25 participants with ASD, and 25 participants with combined ASD and epilepsy. When controlling for age, gender, race, level of ID, and hearing and visual impairments, results of the MANOVA revealed significant differences among groups, Wilks's Lambda =.76, F(15, 254)= 1.82, p <.05, eta(2) =.09. A one-way ANOVA was conducted for each of the five subscales of the ASD-CA as follow-up tests to the MANOVA. Groups differed significantly Anxiety/Repetitive Behavior subscale, F(3, 96) = 2.93, p <.05, eta(2) =.08, Irritability/Behavior excess subscale, F(3, 96) = 4.74, p <.01, eta(2) =.13, Attention/Hyperactivity subscale, F(3, 96) = 5.18, p <.01, eta(2) =.14, and Depressive Symptoms subscale, F(3, 96) = 3.73, p <.01, eta(2) = .10. Trend analysis demonstrated that individuals with ID expressing combined comorbid ASD and epilepsy were significantly more impaired than the control group (ID only) or groups containing only a single comorbid factor with ID (ASD or epilepsy only). Implications of these findings elucidate the nature of these disorders and their influence on patient care and management. (C) 2010 Elsevier Ltd. All rights reserved.
C1 [Smith, Kimberly R. M.] Louisiana State Univ, Dept Psychol, Beatrice State Dev Ctr, Beatrice, NE 68310 USA.
RP Smith, KRM (reprint author), Louisiana State Univ, Dept Psychol, Beatrice State Dev Ctr, Beatrice, NE 68310 USA.
EM kimberlysmith15@gmail.com
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NR 52
TC 83
Z9 83
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0891-4222
J9 RES DEV DISABIL
JI Res. Dev. Disabil.
PD MAY-JUN
PY 2010
VL 31
IS 3
BP 743
EP 749
DI 10.1016/j.ridd.2010.01.016
PG 7
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA 583GT
UT WOS:000276662400015
PM 20206472
ER
PT J
AU Fernell, E
Hedvall, A
Norrelgen, F
Eriksson, M
Hoglund-Carlsson, L
Barnevik-Olsson, M
Svensson, L
Holm, A
Westerlund, J
Gillberg, C
AF Fernell, Elisabeth
Hedvall, Asa
Norrelgen, Fritiof
Eriksson, Mats
Hoglund-Carlsson, Lotta
Barnevik-Olsson, Martina
Svensson, Liselotte
Holm, Annette
Westerlund, Joakim
Gillberg, Christopher
TI Developmental profiles in preschool children with autism spectrum
disorders referred for intervention
SO RESEARCH IN DEVELOPMENTAL DISABILITIES
LA English
DT Article
DE Autism spectrum disorder; Developmental disorder; Cognitive function;
Language delay
ID INTENSIVE BEHAVIORAL INTERVENTION; SWEDISH CHILDREN; COMMUNICATIVE
DEVELOPMENT; ATTENTION; DEFICITS; MOTOR; REGRESSION; LANGUAGE; SAMPLE
AB The aim was to characterize the panorama of developmental disorders in 208 preschool children with a clinical diagnosis of autism spectrum disorder (ASD), referred to a specialized centre, the Autism Centre for Young Children (ACYC), for intervention. At the centre, a research team examined all children according to structured protocols and interviews. All available test data from their assessments prior to referral were scrutinized. The boy:girl ratio was 5.5:1. In 22% of the total group a period of regression, including speech and language, had occurred. Epilepsy had been diagnosed in 6% of the children. In 38% of the children there was a definite or highly suspected learning disability/mental retardation according to cognitive test results. About the same proportion had a developmental delay that at the time of assessment could not be definitely classified and in 23% there were clear indications of a normal intellectual function. About 40% of the group exhibited hyperactivity. Differences in expressive vocabulary and adaptive functioning were strongly related to cognitive level. About 20% of the group had AD as the dominating developmental disorder, i.e., they represented a clinical picture of "classic" autism. The majority in this group also had learning disability. Another 20%, had ASD combined with a normal intellectual level, some of these conformed to the clinical picture of Asperger syndrome. In a relatively large group (more than half) learning disability or a general developmental delay was as evident as the ASD. In a smaller group (8%) ASD criteria were questionably met. In this group attention deficits in connection with speech and language problems were prominent. The highly individual developmental profiles seen in children with ASDs have to be taken into account when planning intervention and follow-up. The children's medical characteristics also vary considerably and will be detailed in a further report. (C) 2010 Elsevier Ltd. All rights reserved.
C1 [Fernell, Elisabeth] Karolinska Univ Hosp, Autism Ctr Young Children Handicap & Habilitat &, Stockholm, Sweden.
[Fernell, Elisabeth] Autism Ctr Young Children Handicap & Habilitat, Stockholm, Sweden.
[Fernell, Elisabeth] FoU Ctr, Skovde, Sweden.
[Fernell, Elisabeth] Skaraborgs Hosp, Unit Neurodev Disorders, Mariestad, Sweden.
[Norrelgen, Fritiof; Svensson, Liselotte] Karolinska Univ Hosp, Dept Speech & Language Pathol, Stockholm, Sweden.
[Hoglund-Carlsson, Lotta] Astrid Lindgren Childrens Hosp, Dept Paediat, Stockholm, Sweden.
[Barnevik-Olsson, Martina] PRIMA Child & Adolescent Psychiat, Stockholm, Sweden.
[Svensson, Liselotte] Karolinska Inst, Div Speech & Language Pathol, CLINTEC, S-10401 Stockholm, Sweden.
[Holm, Annette] Karolinska Univ Hosp, Dept Psychol, Stockholm, Sweden.
[Westerlund, Joakim] Stockholm Univ, Dept Psychol, Stockholm, Sweden.
[Gillberg, Christopher] Univ Gothenburg, Sahlgrenska Acad, Inst Neurosci & Physiol Child & Adolescent Psychi, Gothenburg, Sweden.
RP Fernell, E (reprint author), Karolinska Univ Hosp, Autism Ctr Young Children Handicap & Habilitat &, Stockholm, Sweden.
EM elisabeth.fernell@karolinska.se
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NR 36
TC 35
Z9 37
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0891-4222
J9 RES DEV DISABIL
JI Res. Dev. Disabil.
PD MAY-JUN
PY 2010
VL 31
IS 3
BP 790
EP 799
DI 10.1016/j.ridd.2010.02.003
PG 10
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA 583GT
UT WOS:000276662400021
PM 20207104
ER
PT J
AU Al Anbar, NN
Dardennes, RM
Prado-Netto, A
Kaye, K
Contejean, Y
AF Al Anbar, Nebal N.
Dardennes, Roland M.
Prado-Netto, Arthur
Kaye, Kelley
Contejean, Yves
TI Treatment choices in autism spectrum disorder: The role of parental
illness perceptions
SO RESEARCH IN DEVELOPMENTAL DISABILITIES
LA English
DT Article
DE Autism; Parents; Illness beliefs; Health behavior; IPQ-R
ID QUESTIONNAIRE IPQ-R; ALTERNATIVE MEDICINE; SELF-REGULATION; CHILDREN;
COMPLEMENTARY; MEDICATION; MANAGEMENT; BELIEFS
AB A cross-sectional design was employed. Parents of a child with Autism Spectrum Disorder (ASH) were asked to complete a modified version of the Revised Illness-Perception Questionnaire (IPQ-RA) and answer questions about information-seeking activities and treatments used. Internal consistency, construct validity, and factor structure were assessed. Multivariate logistic regressions were performed. Eighty-nine parents having a child with ASD took part in the study. Five subscales of the IPQ-R were replicated. Causes were split into personal, external and hereditary factors. The most highly rated main cause was a genetic cause. Perception of seriousness of the disease was associated with the use of educative methods and unpredictable course of disorder associated with drug use. A higher sense of personal control was associated with reduced use of nutritional or pharmaceutical treatments. Attendance to training programs was associated with higher hereditary beliefs and lower perception of cyclical timeline. The IPQ-RA captures components of representations of autism and provides a reliable mean for exploring illness concept in parents of a child with ASH. Some illness dimensions may prevent parents from having the opportunity to modify their concept of autism. Such measure may be useful for assessing the modification of potentially malleable beliefs with psychoeducational interventions. (C) 2010 Elsevier Ltd. All rights reserved.
C1 [Al Anbar, Nebal N.; Prado-Netto, Arthur] Univ Paris 05, Fac Psychol, Grad Sch 261, F-92774 Boulogne, France.
[Dardennes, Roland M.] Fac Med Paris Descartes, F-75270 Paris 06, France.
[Dardennes, Roland M.; Kaye, Kelley; Contejean, Yves] Hosp St Anne, F-75014 Paris, France.
[Dardennes, Roland M.] INSERM, Ctr Psychiat & Neurosci, UMR 894, F-75014 Paris, France.
RP Dardennes, RM (reprint author), Serv Pr ROUILLON, Clin Malad Mentales & Encephale, 100 Rue Sante, F-75674 Paris 14, France.
EM nebalu2001@hotmail.com; r.dardennes@gmail.com; saturno_68@hotmail.com;
k.kaye@ch-sainte-anne.fr; y.contejean@ch-sainte-anne.fr
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NR 41
TC 19
Z9 19
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0891-4222
J9 RES DEV DISABIL
JI Res. Dev. Disabil.
PD MAY-JUN
PY 2010
VL 31
IS 3
BP 817
EP 828
DI 10.1016/j.ridd.2010.02.007
PG 12
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA 583GT
UT WOS:000276662400025
PM 20299185
ER
PT J
AU Martinez-Levy, GA
Vasquez-Medina, JA
Cruz-Fuentes, CS
AF Ariadna Martinez-Levy, Gabriela
Alberto Vasquez-Medina, Josue
Sabas Cruz-Fuentes, Carlos
TI Genome diversity of the Mexican Mestizo population: Scopes and
perspectives for develop Genetic Psychiatric Research
SO SALUD MENTAL
LA Spanish
DT Article
DE Genome; HapMap; Mexican; polymorphisms; psychiatry; complex disorders
ID WIDE ASSOCIATION; MENTAL-HEALTH; DISORDERS; DISEASES; ENDOPHENOTYPES;
PROJECT; PANEL; ERA; DSM
AB A few months ago the paper entitled "Analysis of genomic diversity in Mexican Mestizo populations to develop genomic medicine in Mexico" by Solezzi et at was published in the Proceedings of the Notional Academy of Medicine USA Beyond its genuine scientific merits, we consider important to comment and discuss it, as some of their scopes and implications have caused not only D wide interest but also some concern in the scientific community and in society as a whole. We focused particularly in the possible impact that it could have in the development of psychiatric genetics in Mexico and Latin America.
Firstly, a brief recapitulation of the published work is showed, and its principal data are discussed on the ground of the specialized literature
What is the background of this study and why it is important to develop a HapMap of the Mexican population(2) It is well known that most of the complex diseases, as is the case for psychiatric conditions, have an important genetic associated component. It is expected that the identification of these genetic factors will be of the most importance in the understanding of etiology, diagnosis, prognosis and therapeutic improvement for psychiatric medicine
The information provided by the collection of millions of single nucleotide polymorphisms (SNPs) has been used to develop the so-called international haplotype map (HapMap) Protect. The human haplotype blocks catalog allows an important reduction in the number of SNPs that are necessary to perform linkage and genetic association studies, mainly those of the Genome Wide Association Studies (GWAS) category
However, it is recognized that the frequency of these polymorphisrns differs significantly among ethnic groups, so the data published by Solezzi et at are aimed to develop a HapMap particularly oriented to the Mexican mestizo population This information will be of outstanding importance in studies including Mexican subtracts in order to select the most informative group of SNPs and also to control for possible population stratification flaws. However, achievement of these objectives will need much more work to be done, as for example should it be mandatory to analyze a greater number of polymorphisms, develop genome re-sequenciation protects and include other Mexican subpopulations in the analysis
How this results will help psychiatric genetics in Mexico(2) As noted above, there is substantial evidence that genetics plays an important influence in the phenotypic expression of mental disorders, however, the effort to identify the specific genetic variants associated with psychiatric conditions has not been very successful Although multiple reasons could be invoked related to this limited success, here we focus in two specific topics
The first one is related to the candidate gene approach in genetic association studies, in which researchers based on a logic scientific hypothesis evaluate specific genetic variants putatively related to the disorder of interest e the candidate genes hypothesis) However, the possibility of identification of the associated genetic risk variants is importantly reduced, as the knowledge about complex disorders and particularly those related with mental problems is mostly incomplete. The continuous advances in neurobiological and psychological knowledge provides hope for future improvement and the generation of new ideas On the other hand, the alternative and technically feasible approach to analyze simultaneously hundred of thousands, even millions, of genetic variants all along the human genome with no regarding of a priori candidate genes (as in the Genome Wide Association Studies, GWAS), has reached the psychiatric genetics arena In this regard, it is worth noting that several published studies of GWAS and psychiatric disorders have recently appeared and have contributed to develop important clues Particularly interesting are those pointing out to the until recently unexplored role of Copy Number Variants (CNVs) associated to some forms of autism and schizophrenia
It is worth noting that most GWAS are based in the common disorder-common variant hypothesis (where genetic polymorphisms studied have a frequency >5% in the general population) However, the alternative view of the common disorder-rare variant hypothesis have also been proposed As most of the rare SNPs have not been identified in the current effort of the HapMap protect, a re-sequenciation analysis of human genomes of particular ethnic groups seems to be mandatory
The other relevant issue is related to the following question Are current psychiatric diagnostic categories proper phenotypes for the study of genetic aspects associated with mental disorders(2) Diagnosis in psychiatry is based mainly in the identification and interpretation from clinicians of the patient 's cardinal symptoms
However, overlapping of symptoms between nosological categories, comorbidity and changes in natural history of the disorder associated or not to therapeuthical improvements are issues hampering efforts in psychiatric genetics.
At this point it is important to recall that psychiatric diagnostic categories have evolved along the last four or five decades after intense discussion among experts However, even recognizing the clinical virtues of current consensus (integrated for example in the DSM-IV-R), it is clear that is still a pending issue, awaiting the most recent contributions from different areas of knowledge, including genetics
Moreover, unlike other complex disorders like hypertension or diabetes, where use of clinical and relevant phenotypes, such as blood pressure and levels of blood glucose, can increase the power of genetic analysis, in mental disorders this kind of quantitative phenotypes are rare or unknown, which restrains the process to find genetic variants associated with psychiatric disorders, independently of the study design and the technology of analysis
In brief, in countries as ours, composed mainly by mestizo population, is of the utmost importance for molecular genetics studies to obtain specific information about its genetic composition In this sense, the National Institute of Genomic Medicine has made an important contribution, however, and as correctly stated by Solezzi et al., "much more work needs to be done.
We argue that the even the deepest knowledge in genetic variation or use of state-of-the-art technology is not enough to boost the development of psychiatric genetics research Re-evaluation of current clinical phenotypes and/or identification of new and relevant intermediate or endo- phenotypes in psychiatry are no less important.
Additionally, it will be necessary to integrate to the complex equation of the genetics of complex disorders the seminal role of "environment. In this respect we are strong advocates of multidisciplinary research as the clue for better understanding the etiology of mental disorders
Finally, we hope this work will help to elucidate some of the questions and concerns originated from the published article by Silva-Solezzi et al
C1 [Ariadna Martinez-Levy, Gabriela; Sabas Cruz-Fuentes, Carlos] Inst Nacl Psiquiatria Ramon de la Fuente Muniz, Subdirecc Invest Clin, Dept Genet, Mexico City 14370, DF, Mexico.
RP Cruz-Fuentes, CS (reprint author), Inst Nacl Psiquiatria Ramon de la Fuente Muniz, Subdirecc Invest Clin, Dept Genet, Calz Mexico Xochimilco 101, Mexico City 14370, DF, Mexico.
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
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NR 42
TC 0
Z9 0
PU INST MEX PSIQUIATRIA
PI MEXICO CITY
PA CALZ MEXICO-XOCHIMILCO #101, MEXICO CITY 22 DF, MEXICO
SN 0185-3325
J9 SALUD MENT
JI Salud Ment.
PD MAY-JUN
PY 2010
VL 33
IS 3
BP 273
EP 280
PG 8
WC Psychiatry
SC Psychiatry
GA 627MV
UT WOS:000280044800008
ER
PT J
AU Leitman, DI
Laukka, P
Juslin, PN
Saccente, E
Butler, P
Javitt, DC
AF Leitman, David I.
Laukka, Petri
Juslin, Patrik N.
Saccente, Erica
Butler, Pamela
Javitt, Daniel C.
TI Getting the Cue: Sensory Contributions to Auditory Emotion Recognition
Impairments in Schizophrenia
SO SCHIZOPHRENIA BULLETIN
LA English
DT Article
DE schizophrenia; social cognition; prosody; emotion; speech;
multidimensional scaling
ID DIFFERENTIAL DEFICIT; MISMATCH NEGATIVITY; PERCEPTION; DYSFUNCTION;
EXPRESSION; FACES; 1ST-EPISODE; PERFORMANCE; INTONATION; AUTISM
AB Individuals with schizophrenia show reliable deficits in the ability to recognize emotions from vocal expressions. Here, we examined emotion recognition ability in 23 schizophrenia patients relative to 17 healthy controls using a stimulus battery with well-characterized acoustic features. We further evaluated performance deficits relative to ancillary assessments of underlying pitch perception abilities. As predicted, patients showed reduced emotion recognition ability across a range of emotions, which correlated with impaired basic tone matching abilities. Emotion identification deficits were strongly related to pitch-based acoustic cues such as mean and variability of fundamental frequency. Whereas healthy subjects' performance varied as a function of the relative presence or absence of these cues, with higher cue levels leading to enhanced performance, schizophrenia patients showed significantly less variation in performance as a function of cue level. In contrast to pitch-based cues, both groups showed equivalent variation in performance as a function of intensity-based cues. Finally, patients were less able than controls to differentiate between expressions with high and low emotion intensity, and this deficit was also correlated with impaired tone matching ability. Both emotion identification and intensity rating deficits were unrelated to valence of intended emotions. Deficits in both auditory emotion identification and more basic perceptual abilities correlated with impaired functional outcome. Overall, these findings support the concept that auditory emotion identification deficits in schizophrenia reflect, at least in part, a relative inability to process critical acoustic characteristics of prosodic stimuli and that such deficits contribute to poor global outcome.
C1 [Leitman, David I.; Saccente, Erica; Butler, Pamela; Javitt, Daniel C.] Nathan S Kline Inst Psychiat Res, Program Cognit Neurosci & Schizophrenia, Orangeburg, NY 10962 USA.
[Leitman, David I.; Javitt, Daniel C.] CUNY City Coll, Program Cognit Neurosci, New York, NY 10031 USA.
[Leitman, David I.] Univ Penn, Dept Neuropsychiat, Brain Behav Lab, Philadelphia, PA 19104 USA.
[Laukka, Petri; Juslin, Patrik N.] Uppsala Univ, Dept Psychol, Uppsala, Sweden.
[Butler, Pamela; Javitt, Daniel C.] NYU, Sch Med, Dept Psychiat, New York, NY USA.
RP Javitt, DC (reprint author), Nathan S Kline Inst Psychiat Res, Program Cognit Neurosci & Schizophrenia, 140 Old Orangeburg Rd, Orangeburg, NY 10962 USA.
EM javitt@nki.rfmh.org
RI Laukka, Petri/B-5259-2008
FU National Institute of Mental Health (NRSA) [F1-MH067339, K02 MH01439,
R01 MH49334]
FX FundingNational Institute of Mental Health (NRSA F1-MH067339 to D. I.
L., K02 MH01439 to D.C.J., R01 MH49334 to D.C.J.).
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NR 40
TC 45
Z9 45
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0586-7614
J9 SCHIZOPHRENIA BULL
JI Schizophr. Bull.
PD MAY
PY 2010
VL 36
IS 3
BP 545
EP 556
DI 10.1093/schbul/sbn115
PG 12
WC Psychiatry
SC Psychiatry
GA 606RH
UT WOS:000278444400016
PM 18791077
ER
PT J
AU Fatemi, SH
AF Fatemi, S. Hossein
TI Co-occurrence of neurodevelopmental genes in etiopathogenesis of autism
and schizophrenia
SO SCHIZOPHRENIA RESEARCH
LA English
DT Letter
ID CEREBELLAR CORTICES; EXPRESSION; PARIETAL; REELIN; BRAIN
C1 [Fatemi, S. Hossein] Univ Minnesota, Sch Med, Dept Psychiat, Minneapolis, MN 55455 USA.
[Fatemi, S. Hossein] Univ Minnesota, Sch Med, Dept Pharmacol, Minneapolis, MN 55455 USA.
[Fatemi, S. Hossein] Univ Minnesota, Sch Med, Dept Neurosci, Minneapolis, MN 55455 USA.
RP Fatemi, SH (reprint author), Univ Minnesota, Sch Med, Dept Psychiat, 420 Delaware St SE,MMC 392, Minneapolis, MN 55455 USA.
EM fatem002@umn.edu
CR Braun NN, 2007, NEUROREPORT, V18, P1841
Bullock WM, 2008, AM J PSYCHIAT, V165, P1594, DOI 10.1176/appi.ajp.2008.07121845
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NR 10
TC 8
Z9 9
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0920-9964
J9 SCHIZOPHR RES
JI Schizophr. Res.
PD MAY
PY 2010
VL 118
IS 1-3
BP 303
EP 304
DI 10.1016/j.schres.2010.01.018
PG 2
WC Psychiatry
SC Psychiatry
GA 603NE
UT WOS:000278214500044
PM 20153953
ER
PT J
AU Kronk, R
Bishop, EE
Raspa, M
Bickel, JO
Mandel, DA
Bailey, DB
AF Kronk, Rebecca
Bishop, Ellen E.
Raspa, Melissa
Bickel, Julie O.
Mandel, Daniel A.
Bailey, Donald B., Jr.
TI Prevalence, Nature, and Correlates of Sleep Problems Among Children with
Fragile X Syndrome Based on a Large Scale Parent Survey
SO SLEEP
LA English
DT Article
DE Sleep; Fragile X syndrome; survey
ID ASSIGNING ICF CODES; DEVELOPMENTAL-DISABILITIES; INTELLECTUAL
DISABILITY; SYNAPTIC PLASTICITY; ANGELMAN-SYNDROME; DISORDERS;
MELATONIN; PATTERNS; AUTISM; BEHAVIOR
AB Study Objectives: This study reports on current child sleep difficulties reported by parents of children with Fragile X syndrome (FXS). We address prevalence and type of sleep problems (e.g., difficulty falling asleep, frequent awakenings); type and effectiveness of medical and behavioral treatments (e.g., medication, surgery, environmental changes); and explore specific child and family characteristics (e.g., child age, child gender, co-occurring conditions) as possible predictors of child sleep difficulties.
Design/Participants: This study is part of a larger survey addressing needs of families with children with FXS. This article focuses on the families who responded to the survey sleep questions, had one or more children with the full mutation FXS, and who reside in the United States. The mean age for male and female children in this group was 15 years and 16 years respectively (N = 1,295).
Results: Parents reported that 32% of the children with FXS currently experience sleep difficulties; 84% of those children are reported to have >= 2 current sleep problems. Problems falling asleep and frequent night awakenings were the most frequently reported difficulties; 47% of males and 40% of females received >= 1medication to help with sleep. Children with more problematic health or behavioral characteristics had a higher likelihood of having current sleep problems.
Conclusions: Our survey provides the most representative sample to date of sleep problems in children with FXS or any other neurodevelopmental disability. This large scale survey establishes a foundation for the prevalence of sleep disorders in children with FXS.
C1 [Kronk, Rebecca] Univ Pittsburgh, Childrens Hosp Pittsburgh, UPMC, UCLID Ctr,Child Dev Unit,Fragile Ctr 10, Pittsburgh, PA 15201 USA.
[Bishop, Ellen E.; Raspa, Melissa; Bailey, Donald B., Jr.] RTI Int, Res Triangle Pk, NC USA.
[Bickel, Julie O.] Childrens Hosp Pittsburgh, Dept Pediat, Pittsburgh, PA 15213 USA.
[Mandel, Daniel A.] Oak Ridge Inst Sci & Educ, Oak Ridge, TN USA.
[Mandel, Daniel A.] Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA USA.
RP Kronk, R (reprint author), Univ Pittsburgh, Childrens Hosp Pittsburgh, UPMC, UCLID Ctr,Child Dev Unit,Fragile Ctr 10, 45th & Penn, Pittsburgh, PA 15201 USA.
EM becky.kronk@chp.edu
FU Centers for Disease Control and Prevention (CDC); Association for
Prevention Teaching and Research (APTR) [U50/CCU300860, TS-1380]
FX Preparation of this article was supported in part by the Centers for
Disease Control and Prevention (CDC) and the Association for Prevention
Teaching and Research (APTR) Cooperative Agreement No. U50/CCU300860,
Project TS-1380.
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NR 53
TC 22
Z9 22
PU AMER ACAD SLEEP MEDICINE
PI WESTCHESTER
PA ONE WESTBROOK CORPORATE CTR, STE 920, WESTCHESTER, IL 60154 USA
SN 0161-8105
J9 SLEEP
JI Sleep
PD MAY 1
PY 2010
VL 33
IS 5
BP 679
EP 687
PG 9
WC Clinical Neurology; Neurosciences
SC Neurosciences & Neurology
GA 590NC
UT WOS:000277232200015
PM 20469810
ER
PT J
AU Gaffan, EA
Martins, C
Healy, S
Murray, L
AF Gaffan, Elizabeth A.
Martins, Carla
Healy, Sarah
Murray, Lynne
TI Early Social Experience and Individual Differences in Infants' Joint
Attention
SO SOCIAL DEVELOPMENT
LA English
DT Article
DE joint attention; infancy; longitudinal; maternal sensitivity
ID POSTNATAL DEPRESSION SCALE; MOTHER-INFANT; COGNITIVE SKILLS;
VISUAL-ATTENTION; COMMUNICATION; AUTISM; CHILDREN; INTERSUBJECTIVITY;
SENSITIVITY; BEHAVIORS
AB Fifty-nine healthy infants were filmed with their mothers and with a researcher at two, four, six and nine months in face-to-face play, and in toy-play at six and nine months. During toy-play at both ages, two indices of joint attention (JA)-infant bids for attention, and percent of time in shared attention-were assessed, along with other behavioural measures. Global ratings were made at all four ages of infants' and mothers' interactive style. The mothers varied in psychiatric history (e.g., half had experienced postpartum depression) and socioeconomic status, so their interactive styles were diverse. Variation in nine-month infant JA-with mother and with researcher-was predicted by variation in maternal behaviour and global ratings at six months, but not at two or four months. Concurrent adult behaviour also influenced nine-month JA, independent of infant ratings. Six-month maternal behaviours that positively predicted later JA (some of which remained important at nine months) included teaching, conjoint action on a toy, and global sensitivity. Other behaviours (e.g., entertaining) negatively predicted later JA. Findings are discussed in terms of social-learning and neurobiological accounts of JA emergence.
C1 [Gaffan, Elizabeth A.] Univ Reading, Sch Psychol & Clin Language Sci, Dept Psychol, Reading RG6 6AL, Berks, England.
[Martins, Carla] Univ Minho, P-4719 Braga, Portugal.
RP Gaffan, EA (reprint author), Univ Reading, Sch Psychol & Clin Language Sci, Dept Psychol, Reading RG6 6AL, Berks, England.
EM e.a.gaffan@reading.ac.uk
RI Martins, Carla/A-1664-2011
OI Martins, Carla/0000-0003-3506-674X
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NR 53
TC 10
Z9 12
PU WILEY-BLACKWELL PUBLISHING, INC
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0961-205X
J9 SOC DEV
JI Soc. Dev.
PD MAY
PY 2010
VL 19
IS 2
BP 369
EP 393
DI 10.1111/j.1467-9507.2008.00533.x
PG 25
WC Psychology, Developmental
SC Psychology
GA 570CG
UT WOS:000275648600008
ER
PT J
AU Milenkovic, S
Belojevic, G
Kocijancic, R
AF Milenkovic, Sanja
Belojevic, Goran
Kocijancic, Radojka
TI Left-Handedness and Health
SO SRPSKI ARHIV ZA CELOKUPNO LEKARSTVO
LA Serbian
DT Review
DE functional laterality; development; health; disease
ID LEFT-HANDERS; CEREBRAL LATERALIZATION; READING-DISABILITY; RISK-FACTOR;
PREFERENCE; DISEASE; ASSOCIATION; DISORDER; DYSLEXIA; CHILDREN
AB Hand dominance is defined as a proneness to use one hand rather than another in performing the majority of activities and this is the most obvious example of cerebral lateralization and an exclusive human characteristic. Left-handed people comprise 6-14% of the total population, while in Serbia, this percentage is 5-10%, moving from undeveloped to developed environments, where a socio-cultural pressure is less present. There is no agreement between investigators who in fact may be considered a left-handed person, about the percentage of left-handers in the population and about the etiology of left-handedness. In the scientific literature left-handedness has been related to health disorders (spine deformities, immunological disorders, migraine, neurosis, depressive psychosis, schizophrenia, insomnia, homosexuality, diabetes mellitus, arterial hypertension, sleep apnea, enuresis nocturna and Down Syndrome), developmental disorders (autism, dislexia and sttutering) and traumatism. The most reliable scientific evidences have been published about the relationship between left-handedness and spinal deformities in school children in puberty and with traumatism in general population. The controversy of other results in up-to-now investigations of health aspects of left-handedness may partly be explained by a scientific disagreement whether writing with the left hand is a sufficient criterium for left-handedness, or is it necessary to investigate other parameters for laterality assessment. Explanation of health aspects of left-handedness is dominantly based on Geschwind-Galaburda model about "anomalous" cerebral domination, as a consequence of hormonal disbalance.
C1 [Milenkovic, Sanja] Univ Belgrade, Sch Med, Fak Med, Inst Hyg & Med Ecol, Belgrade 11000, Serbia.
RP Milenkovic, S (reprint author), Univ Belgrade, Sch Med, Fak Med, Inst Hyg & Med Ecol, Dr Subotica 8, Belgrade 11000, Serbia.
EM sanjavecko@yahoo.com
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NR 49
TC 1
Z9 2
PU SRPSKO LEKARSKO DRUSTVO
PI BEOGRAD
PA UREDNISTVO CASOPISA SRPSKI ARHIV, UL DZORDZA VASINGTONA 19, BEOGRAD,
11000, SERBIA
SN 0370-8179
J9 SRP ARK CELOK LEK
JI Srp. Ark. Celok. Lek.
PD MAY-JUN
PY 2010
VL 138
IS 5-6
BP 387
EP 390
DI 10.2298/SARH1006387M
PG 4
WC Medicine, General & Internal
SC General & Internal Medicine
GA 617NW
UT WOS:000279288700024
PM 20607990
ER
PT J
AU Perminova, GA
Burdukova, YA
Stroganova, TA
AF Perminova, G. A.
Burdukova, Yu. A.
Stroganova, T. A.
TI The profiles of early non-verbal communication in children suffering
Williams' syndrome and autism
SO VOPROSY PSIKHOLOGII
LA Russian
DT Article
DE joint attention; Williams' syndrome; autism
AB The investigation was aimed at the description of specificity of early communication with an adult and especially triad interaction in preschoolers suffering Williams' syndrome and autism. It was supposed that the initiation of triad interaction in such children must be lower than in typically developing children. The system of early communication in children with psycho-motor development corresponding to 14-30 months of age was investigated by Early Social Communication Scale. The data obtained show the similarity in profiles of early non-verbal communication in children suffering Williams' syndrome and autism as concerning initiation of interaction as well as total disruption of communicative behavior in children with autism and irregularity of communication profile in children suffering Williams' syndrome. These results confirm the notion that the breach of initiation of joint attention in early age cannot serve as differential diagnostic characteristic of autism.
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2003, MEZHDUNARODNAYA STAT
NR 33
TC 0
Z9 0
PU MEZHDUNARODNAYA KNIGA
PI MOSCOW
PA 39 DIMITROVA UL., MOSCOW, 113095, RUSSIA
SN 0042-8841
J9 VOP PSIKHOL+
JI Vopr. Psikhologii
PD MAY-JUN
PY 2010
IS 3
BP 20
EP +
PG 12
WC Psychology, Educational
SC Psychology
GA 629FH
UT WOS:000280179900003
ER
PT J
AU Lombardo, MV
Baron-Cohen, S
AF Lombardo, Michael V.
Baron-Cohen, Simon
TI Unraveling the paradox of the autistic self
SO WILEY INTERDISCIPLINARY REVIEWS-COGNITIVE SCIENCE
LA English
DT Review
ID HIGH-FUNCTIONING AUTISM; SPECTRUM DISORDERS; SOCIAL COGNITION;
ASPERGER-SYNDROME; AUTOBIOGRAPHICAL MEMORY; EPISODIC MEMORY; JOINT
ATTENTION; CHILDREN; RECOGNITION; BRAIN
AB Paradoxically, individuals with autism spectrum conditions have been characterized as both impaired in self-referential cognitive processing, yet also egocentric. How can the self in autism be both 'absent' (i.e., impaired self-referential cognition), yet 'all too present' (i.e., egocentric)? In this paper, we first review evidence in support of both claims. Second, we highlight new evidence illustrating atypical function of neural systems underlying self-representation in autism. We suggest that egocentrism and impaired self-referential cognition are not independent phenomena. Instead, both egocentrism and impaired self-referential cognition in autism can be resolved as expressions of one common mechanism linked to the atypical function of neural circuitry coding for self-relevant information. We discuss how autism provides a unique window into the neurodevelopmental mechanisms enabling a critical developmental transition in self-awareness. This transition involves a dual understanding that one is similar to, yet distinct from others. The neural and cognitive basis of this developmental transition is central to understanding the development of social cognition as well as the paradox of the autistic self and its relation to social impairment in autism. (C) 2010 John Wiley & Sons, Ltd. WIREs Cogn Sci 2010 1 393-403
C1 [Lombardo, Michael V.; Baron-Cohen, Simon] Univ Cambridge, Autism Res Ctr, Dept Psychiat, Cambridge CB2 8AH, England.
RP Lombardo, MV (reprint author), Univ Cambridge, Autism Res Ctr, Dept Psychiat, Douglas House,18B Trumpington Rd, Cambridge CB2 8AH, England.
EM ml437@cam.ac.uk
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NR 94
TC 16
Z9 16
PU WILEY PERIODICALS, INC
PI MALDEN
PA COMMERCE PLACE, 350 MAIN STREET, MALDEN, MA 02148-529 USA
SN 1939-5078
J9 WIRES COGN SCI
JI Wiley Interdiscip. Rev.-Cogn. Sci.
PD MAY-JUN
PY 2010
VL 1
IS 3
BP 393
EP 403
DI 10.1002/wcs.45
PG 11
WC Psychology, Experimental
SC Psychology
GA 863NT
UT WOS:000298172200008
ER
PT J
AU Russell, PSS
Daniel, A
Russell, S
Mammen, P
Abel, JS
Raj, LE
Shankar, SR
Thomas, N
AF Russell, Paul S. S.
Daniel, Anna
Russell, Sushila
Mammen, Priya
Abel, Julie S.
Raj, Lydia E.
Shankar, Satya Raj
Thomas, Naveen
TI Diagnostic accuracy, reliability and validity of Childhood Autism Rating
Scale in India
SO WORLD JOURNAL OF PEDIATRICS
LA English
DT Article
DE autism; diagnostic accuracy; India; reliability; validation
ID PERVASIVE DEVELOPMENTAL DISORDERS; SPECTRUM DISORDERS; DSM-IV; BEHAVIOR
CHECKLIST; TOKYO VERSION; CARS; ADOLESCENTS; CRITERIA; CHILDREN;
PREVALENCE
AB Background: Since there is no established measure for autism in India, we evaluated the diagnostic accuracy, reliability and validity of Childhood Autism Rating Scale (CARS).
Methods: Children and adolescents suspected of having autism were identified from the unit's database. Scale and item level scores of CARS were collected and analyzed. Sensitivity, specificity, likelihood ratios and predictive values for various CARS cut-off scores were calculated. Test-retest reliability and inter-rater reliability of CARS were examined. The dichotomized CARS score was correlated with the ICD-10 clinical diagnosis of autism to establish the criterion validity of CARS as a measure of autism. Convergent and divergent validity was calculated. The factor structure of CARS was demonstrated by principal components analysis.
Results: A CARS score of >= 33 (sensitivity = 81.4%, specificity = 78.6%; area under the curve = 81%) was suggested for diagnostic use in Indian populations. The inter-rater reliability (ICC=0.74) and test-retest reliability (ICC=0.81) for CARS were good. Besides the adequate face and content validity, CARS demonstrated good internal consistency (Cronbach's alpha=0.79) and item-total correlation. There was moderate convergent validity with Binet-Kamat Test of Intelligence or Gessell's Developmental Schedule (r=0.42; P=0.01), divergent validity (r=-0.18; P=0.4) with ADD-H Comprehensive Teacher Rating Scale, and high concordance rate with the reference standard, ICD-10 diagnosis (82.52%; Cohen's kappa=0.40, P=0.001) in classifying autism. A 5-factor structure explained 65.34% of variance.
Conclusion: The CARS has strong psychometric properties and is now available for clinical and research work in India.
C1 [Russell, Paul S. S.; Daniel, Anna; Russell, Sushila; Mammen, Priya; Abel, Julie S.; Raj, Lydia E.; Shankar, Satya Raj; Thomas, Naveen] Christian Med Coll & Hosp, Dept Psychiat, Autism Clin, Child & Adolescent Psychiat Unit, Vellore 632002, Tamil Nadu, India.
RP Russell, PSS (reprint author), Christian Med Coll & Hosp, Dept Psychiat, Autism Clin, Child & Adolescent Psychiat Unit, Vellore 632002, Tamil Nadu, India.
EM russell@cmcvellore.ac.in
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NR 33
TC 5
Z9 5
PU ZHEJIANG UNIV SCH MEDICINE
PI HANGZHOU
PA CHILDRENS HOSPITAL, 57 ZHUGAN XIANG, HANGZHOU, 310003, PEOPLES R CHINA
SN 1708-8569
J9 WORLD J PEDIATR
JI World Journal of Pediatrics
PD MAY
PY 2010
VL 6
IS 2
BP 141
EP 147
DI 10.1007/s12519-010-0029-y
PG 7
WC Pediatrics
SC Pediatrics
GA 597QU
UT WOS:000277775800007
PM 20490769
ER
PT J
AU Jimura, K
Konishi, S
Asari, T
Miyashita, Y
AF Jimura, Koji
Konishi, Seiki
Asari, Tomoki
Miyashita, Yasushi
TI Temporal pole activity during understanding other persons' mental states
correlates with neuroticism trait
SO BRAIN RESEARCH
LA English
DT Article
DE False belief; Theory of mind; Personality; fMRI
ID MIRROR-NEURON SYSTEM; EMOTION RECOGNITION; FUNCTIONAL-ANATOMY; NONVERBAL
TASK; MIND; AUTISM; FMRI; EMPATHY; PERSPECTIVE; PEOPLE
AB Comprehension of other persons' mental states is one of the representative cognitive functions involved in social situations. It has been suggested that this function sometimes recruits emotional processes. The present fMRI study examined the neural mechanisms associated with understanding others' mental states, and the conditions that determine the recruitment of the emotional processes. The false belief paradigm, a traditional behavioral paradigm to investigate comprehension of others, was applied to an event-related fMRI analysis, allowing for the extraction of brain activity time-locked to successful understanding of others' mental states. Prominent brain activity was observed in multiple cortical regions including the medial prefrontal cortex, temporo-parietal junction, precuneus, and temporal pole. Then, correlational analyses were performed between the activations and individuals' scores of neuroticism, a personality trait that reflects emotional instability in daily life. It was revealed that the neuroticism scores were positively correlated with the activity in the temporal pole region, but not in the other regions. These results suggest that the emotional processes implemented in the temporal pole are recruited during successful understanding of other persons' mental states, and that the recruitment may be modulated by an emotional personality trait of individual subjects. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Jimura, Koji; Konishi, Seiki; Asari, Tomoki; Miyashita, Yasushi] Univ Tokyo, Sch Med, Dept Physiol, Tokyo 1138654, Japan.
RP Jimura, K (reprint author), Washington Univ, Dept Psychol, CB1125 1 Brookings Dr, St Louis, MO 63108 USA.
EM kjimura@wustl.edu
FU Takeda Foundation; Ministry of Education, Culture, Sports, Science and
Technology of Japan [17500203]; Japan Society for the Promotion of
Science [11149]; Uehara Memorial Foundation; [19002010]
FX This work was supported by a Grant-in-Aid for Specially Promoted
Research (19002010), and Takeda Foundation to Y. M., a Grant-in-Aid for
Scientific Research C (17500203) to S. K. from the Ministry of
Education, Culture, Sports, Science and Technology of Japan, and a
Research Fellowship for young scientists (11149) from the Japan Society
for the Promotion of Science, and Research Fellowship from the Uehara
Memorial Foundation to K. J. We also thank Dr. Bruna Martins for
proofreading the manuscript.
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NR 75
TC 18
Z9 18
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0006-8993
J9 BRAIN RES
JI Brain Res.
PD APR 30
PY 2010
VL 1328
BP 104
EP 112
DI 10.1016/j.brainres.2010.03.016
PG 9
WC Neurosciences
SC Neurosciences & Neurology
GA 596JZ
UT WOS:000277682400010
PM 20226769
ER
PT J
AU Combi, R
Redaelli, S
Beghi, M
Clerici, M
Cornaggia, CM
Dalpra, L
AF Combi, R.
Redaelli, S.
Beghi, M.
Clerici, M.
Cornaggia, C. M.
Dalpra, L.
TI Clinical and genetic evaluation of a family showing both autism and
epilepsy
SO BRAIN RESEARCH BULLETIN
LA English
DT Article
DE Autism; Epilepsy; Genetics; Susceptibility loci
ID PSYCHIATRIC-DISORDERS; SUSCEPTIBILITY GENE; SPECTRUM DISORDERS;
GENOMEWIDE SCREEN; GENOMIC SCREEN; LINKAGE; DISEQUILIBRIUM; ASSOCIATION;
CHILDREN; ETIOLOGY
AB Autism is a strong genetic disorder, with an estimated heritability greater than 90%. Nonetheless, its specific genetic aetiology remains largely unknown. Autism is associated with epilepsy in early childhood and epilepsy occurs in 10-30% of individuals with autism.
Here we report the case of a woman affected by a severe epileptic disorder with an onset at 14 years old. She is affected by a cryptogenetic focal epilepsy with complex partial (psychomotor) and secondarily generalized tonic-clonic seizures, which are drug resistant. The woman is married to a healthy man and has six children: two girls are healthy, a girl and two boys are affected by autism while one boy shows partial seizures. The three children with autism show moderate mental retardation and an EEG with no epileptiform alterations. The child with epileptic seizures shows an asymmetric EEG that is not necessarily pathological. In this family, no chromosomal rearrangements were detected by means of classical cytogenetic analyses. The presence of FRAXA alterations and of microdeletions of the 15q11-g13 chromosome region were also excluded. A genome-wide linkage analysis using microsatellite markers revealed several chromosome regions as possible susceptibility loci. (C) 2010 Elsevier Inc. All rights reserved.
C1 [Redaelli, S.; Clerici, M.; Cornaggia, C. M.; Dalpra, L.] Univ Milano Bicocca, Dept Neurosci & Biomed Technol, I-20052 Monza, Italy.
[Combi, R.] Univ Milano Bicocca, Dept Biosci & Biotechnol, Milan, Italy.
[Beghi, M.] S Gerardo Hosp, Monza, Italy.
RP Dalpra, L (reprint author), Univ Milano Bicocca, Dept Neurosci & Biomed Technol, Via Cadore 48, I-20052 Monza, Italy.
EM leda.dalpra@unimib.it
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NR 30
TC 1
Z9 1
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0361-9230
J9 BRAIN RES BULL
JI Brain Res. Bull.
PD APR 29
PY 2010
VL 82
IS 1-2
BP 25
EP 28
DI 10.1016/j.brainresbull.2010.02.004
PG 4
WC Neurosciences
SC Neurosciences & Neurology
GA 605BG
UT WOS:000278321700006
PM 20152887
ER
PT J
AU Pfeiffer, BE
Zang, T
Wilkerson, JR
Taniguchi, M
Maksimova, MA
Smith, LN
Cowan, CW
Hubert, KM
AF Pfeiffer, Brad E.
Zang, Tong
Wilkerson, Julia R.
Taniguchi, Makoto
Maksimova, Marina A.
Smith, Laura N.
Cowan, Christopher W.
Hubert, Kimberly M.
TI Fragile X Mental Retardation Protein Is Required for Synapse Elimination
by the Activity-Dependent Transcription Factor MEF2
SO NEURON
LA English
DT Article
ID POSTSYNAPTICALLY SILENT SYNAPSES; PRIMARY SOMATOSENSORY CORTEX;
DENDRITIC SPINE; PYRAMIDAL NEURONS; VISUAL-CORTEX; MESSENGER-RNA;
DIFFERENTIATION; PLASTICITY; GENES; POLYRIBOSOMES
AB Fragile X syndrome (FXS), the most common genetic form of mental retardation and autism, is caused by loss-of-function mutations in an RNA-binding protein, Fragile X Mental Retardation Protein (FMRP). Neurons from patients and the mouse Fmr1 knockout (KO) model are characterized by an excess of dendritic spines, suggesting a deficit in excitatory synapse elimination. In response to neuronal activity, myocyte enhancer factor 2 (MEF2) transcription factors induce robust synapse elimination. Here, we demonstrate that MEF2 activation fails to eliminate functional or structural excitatory synapses in hippocampal neurons from Fmr1 KO mice. Similarly, inhibition of endogenous MEF2 increases synapse number in wild-type but not Fmr1 KO neurons. MEF2-dependent synapse elimination is rescued in Fmr1 KO neurons by acute postsynaptic expression of wildtype but not RNA-binding mutants of FMRP. Our results reveal that active MEF2 and FMRP function together in an acute, cell-autonomous mechanism to eliminate excitatory synapses
C1 [Taniguchi, Makoto; Smith, Laura N.; Cowan, Christopher W.] Univ Texas SW Med Ctr Dallas, Dept Psychiat, Dallas, TX 75390 USA.
[Pfeiffer, Brad E.; Zang, Tong; Wilkerson, Julia R.; Maksimova, Marina A.; Hubert, Kimberly M.] Univ Texas SW Med Ctr Dallas, Dept Neurosci, Dallas, TX 75390 USA.
RP Cowan, CW (reprint author), Univ Texas SW Med Ctr Dallas, Dept Psychiat, Dallas, TX 75390 USA.
EM christopher.cowan@utsouthwestern.edu; kimberly.huber@utsouthwestern.edu
FU NIH [1F31NS050992, NS045711, HD052731, DA08227, T32DA07290, F32DA27265];
Autism Speaks; Whitehall Foundation; Simons Foundation
FX This research was supported by NIH grants 1F31NS050992 (B.E.P.),
NS045711, HD052731 (K.M.H.), DA08227 (C.W.C.), T32DA07290 and F32DA27265
(L.N.S.), and grants from Autism Speaks (K.M.H.), the Whitehall (C.W.C.)
and Simons Foundations (K.M.H. and C.W.C.). We would like to thank K.
Loerwald and C. Hale for technical assistance; E. Kavalali for helpful
discussions; and E. Olson for providing the MEF2-EN construct. K.M.H. is
a paid SAB member of Seaside Therapeutics.
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NR 40
TC 52
Z9 54
PU CELL PRESS
PI CAMBRIDGE
PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA
SN 0896-6273
J9 NEURON
JI Neuron
PD APR 29
PY 2010
VL 66
IS 2
BP 191
EP 197
DI 10.1016/j.neuron.2010.03.017
PG 7
WC Neurosciences
SC Neurosciences & Neurology
GA 591NQ
UT WOS:000277308200005
PM 20434996
ER
PT J
AU Bell, JG
Miller, D
MacDonald, DJ
MacKinlay, EE
Dick, JR
Cheseldine, S
Boyle, RM
Graham, C
O'Hare, AE
AF Bell, John Gordon
Miller, Deborah
MacDonald, Donald J.
MacKinlay, Elizabeth E.
Dick, James R.
Cheseldine, Sally
Boyle, Rose M.
Graham, Catriona
O'Hare, Anne E.
TI The fatty acid compositions of erythrocyte and plasma polar lipids in
children with autism, developmental delay or typically developing
controls and the effect of fish oil intake
SO BRITISH JOURNAL OF NUTRITION
LA English
DT Article
DE Blood fatty acids; Autism; Child health; n-3 Highly unsaturated fatty
acids; Fish oils
ID ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; ALPHA-LINOLENIC ACID;
DOCOSAHEXAENOIC ACID; SPECTRUM DISORDERS; PSYCHIATRIC-DISORDERS;
METABOLISM; PREVALENCE; OMEGA-3-FATTY-ACIDS; SUPPLEMENTATION; POPULATION
AB The erythrocyte and plasma fatty acid compositions of children with autism were compared in a case-control study with typically developing (TD) children and with children showing developmental delay (DD). Forty-five autism subjects were age-matched with TD controls and thirty-eight with DD controls. Fatty acid data were compared using paired t tests. In addition, blood fatty acids from treatment-naive autism subjects were compared with autism subjects who had consumed fish oil supplements by two-sample t tests. Relatively few differences were seen between erythrocyte fatty acids in autism and TD subjects although the former had an increased arachidonic acid (ARA):EPA ratio. This ratio was also increased in plasma samples from the same children. No changes in n-3 fatty acids or ARA:EPA ratio were seen when comparing autism with DD subjects but some SFA and MUFA were decreased in the DD subjects, most notably 24 : 0 and 24 : 1, which are essential components of axonal myelin sheaths. However, if multiple comparisons are taken into account, and a stricter level of significance applied, most of these values would not be significant. Autism subjects consuming fish oil showed reduced erythrocyte ARA, 22 : 4n-6, 22 : 5n-6 and total n-6 fatty acids and increased EPA, 22 : 5n-3, 22: 6n-3 and total n-3 fatty acids along with reduced n-6:n-3 and ARA:EPA ratios. Collectively, the autism subjects did not have an underlying phospholipid disorder, based on erythrocyte fatty acid compositions, although the increased ARA:EPA ratio observed suggested that an imbalance of essential highly unsaturated fatty acids may be present in a cohort of autism subjects.
C1 [Bell, John Gordon; MacKinlay, Elizabeth E.; Dick, James R.] Univ Stirling, Inst Aquaculture, Nutr Grp, Stirling FK9 4LA, Scotland.
[Miller, Deborah; O'Hare, Anne E.] Univ Edinburgh, Dept Child Life & Hlth, Edinburgh EH9 1UW, Midlothian, Scotland.
[MacDonald, Donald J.; Boyle, Rose M.] Victoria Infirm, Dept Biochem, Glasgow G42 9TY, Lanark, Scotland.
[Cheseldine, Sally] CFMHS, Edinburgh EH9 1LL, Midlothian, Scotland.
[Graham, Catriona] Western Gen Hosp, Wellcome Trust Clin Res Facil, Edinburgh EH4 2XU, Midlothian, Scotland.
RP Bell, JG (reprint author), Univ Stirling, Inst Aquaculture, Nutr Grp, Stirling FK9 4LA, Scotland.
EM g.j.bell@stir.ac.uk
RI Bell, John/A-8754-2012
FU Office of the Scottish government [CZB-4-256]
FX The present study was supported by funding from the Chief Scientist
Office of the Scottish government (project CZB-4-256).
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NR 52
TC 11
Z9 13
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0007-1145
J9 BRIT J NUTR
JI Br. J. Nutr.
PD APR 28
PY 2010
VL 103
IS 8
BP 1160
EP 1167
DI 10.1017/S0007114509992881
PG 8
WC Nutrition & Dietetics
SC Nutrition & Dietetics
GA 590ST
UT WOS:000277248800010
PM 19995470
ER
PT J
AU Mevorach, C
Hodsoll, J
Allen, H
Shalev, L
Humphreys, G
AF Mevorach, Carmel
Hodsoll, John
Allen, Harriet
Shalev, Lilach
Humphreys, Glyn
TI Ignoring the Elephant in the Room: A Neural Circuit to Downregulate
Salience
SO JOURNAL OF NEUROSCIENCE
LA English
DT Article
ID HUMAN VISUAL-CORTEX; TRANSCRANIAL MAGNETIC STIMULATION; POSTERIOR
PARIETAL CORTEX; HUMAN EXTRASTRIATE CORTEX; CONCURRENT TMS-FMRI;
DIRECTED ATTENTION; BRAIN IMAGES; SUPPRESSION; SELECTION; SEARCH
AB How do we ignore stimuli that are salient but irrelevant when our task is to select a lower salient stimulus? Since bottom-up processes favor high saliency, detection of a low-salient target in the presence of highly salient distractors requires top-down attentional guidance. Previous studies have demonstrated that top-down attention can modulate perceptual processing and also that the control of attention is driven by frontoparietal regions. However, to date, there is no direct evidence on the cause and effect relationship between control regions and perceptual processing. Here, we report the first evidence demonstrating a neural circuit for the downregulation of salient distractors when a low-salient target is selected, combining brain imaging using functional magnetic resonance imaging with brain stimulation by transcranial magnetic stimulation. Using these combined techniques, we were able to identify a cause and effect relationship in the suppression of saliency, based on an interaction between the left intraparietal sulcus (IPS) and a region implicated in visual processing in our task (the left occipital pole). In particular, low-salient stimuli were selected by the left IPS suppressing early visual areas that would otherwise respond to a high-saliency distractor in the task. Apart from providing a first documentation of the neural circuit supporting selection by saliency, these data can be critical for understanding the underlying causes of problems in ignoring irrelevant salience that are found in both acquired and neurodevelopmental disorders (e.g., attention deficit/hyperactivity disorder or autism).
C1 [Mevorach, Carmel; Hodsoll, John; Allen, Harriet; Humphreys, Glyn] Univ Birmingham, Sch Psychol, Behav Brain Sci Ctr, Birmingham B15 2TT, W Midlands, England.
[Shalev, Lilach] Hebrew Univ Jerusalem, Sch Educ, Div Learning Disabil, IL-91905 Jerusalem, Israel.
RP Mevorach, C (reprint author), Univ Birmingham, Sch Psychol, Behav Brain Sci Ctr, Birmingham B15 2TT, W Midlands, England.
EM c.mevorach@bham.ac.uk
RI Hodsoll, John/I-3928-2012
OI Hodsoll, John/0000-0001-7546-9901
FU Medical Research Council (United Kingdom); Biotechnology and Biological
Sciences Research Council (United Kingdom)
FX This work was supported by research grants from the Medical Research
Council (United Kingdom) and the Biotechnology and Biological Sciences
Research Council (United Kingdom).
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NR 42
TC 34
Z9 36
PU SOC NEUROSCIENCE
PI WASHINGTON
PA 11 DUPONT CIRCLE, NW, STE 500, WASHINGTON, DC 20036 USA
SN 0270-6474
J9 J NEUROSCI
JI J. Neurosci.
PD APR 28
PY 2010
VL 30
IS 17
BP 6072
EP 6079
DI 10.1523/JNEUROSCI.0241-10.2010
PG 8
WC Neurosciences
SC Neurosciences & Neurology
GA 589OF
UT WOS:000277159200024
PM 20427665
ER
PT J
AU Gauthier, J
Champagne, N
Lafreniere, RG
Xiong, L
Spiegelman, D
Brustein, E
Lapointe, M
Peng, HS
Cote, M
Noreau, A
Hamdan, FF
Addington, AM
Rapoport, JL
DeLisi, LE
Krebs, MO
Joober, R
Fathalli, F
Mouaffak, F
Haghighi, AP
Neri, C
Dube, MP
Samuels, ME
Marineau, C
Stone, EA
Awadalla, P
Barker, PA
Carbonetto, S
Drapeau, P
Rouleau, GA
AF Gauthier, Julie
Champagne, Nathalie
Lafreniere, Ronald G.
Xiong, Lan
Spiegelman, Dan
Brustein, Edna
Lapointe, Mathieu
Peng, Huashan
Cote, Melanie
Noreau, Anne
Hamdan, Fadi F.
Addington, Anjene M.
Rapoport, Judith L.
DeLisi, Lynn E.
Krebs, Marie-Odile
Joober, Ridha
Fathalli, Ferid
Mouaffak, Faycal
Haghighi, Ali P.
Neri, Christian
Dube, Marie-Pierre
Samuels, Mark E.
Marineau, Claude
Stone, Eric A.
Awadalla, Philip
Barker, Philip A.
Carbonetto, Salvatore
Drapeau, Pierre
Rouleau, Guy A.
CA S2D Team
TI De novo mutations in the gene encoding the synaptic scaffolding protein
SHANK3 in patients ascertained for schizophrenia
SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF
AMERICA
LA English
DT Article
ID CHROMOSOME 22Q; BIPOLAR DISORDER; PREMORBID IQ; LINKAGE; EXPRESSION;
GENOME; TRANSMISSION; ZEBRAFISH; ALLELES; LOCUS
AB Schizophrenia likely results from poorly understood genetic and environmental factors. We studied the gene encoding the synaptic protein SHANK3 in 285 controls and 185 schizophrenia patients with unaffected parents. Two de novo mutations (R1117X and R536W) were identified in two families, one being found in three affected brothers, suggesting germline mosaicism. Zebrafish and rat hippocampal neuron assays revealed behavior and differentiation defects resulting from the R1117X mutant. As mutations in SHANK3 were previously reported in autism, the occurrence of SHANK3 mutations in subjects with a schizophrenia phenotype suggests a molecular genetic link between these two neurodevelopmental disorders.
C1 [Gauthier, Julie; Lafreniere, Ronald G.; Xiong, Lan; Spiegelman, Dan; Cote, Melanie; Noreau, Anne; Marineau, Claude; Rouleau, Guy A.] Univ Montreal, CHU Montreal, Res Ctr, Ctr Excellence Neurom, Montreal, PQ H2L 2W5, Canada.
[Gauthier, Julie; Lafreniere, Ronald G.; Xiong, Lan; Spiegelman, Dan; Cote, Melanie; Noreau, Anne; Marineau, Claude; Rouleau, Guy A.] Univ Montreal, Dept Med, Montreal, PQ H2L 2W5, Canada.
[Champagne, Nathalie; Brustein, Edna; Lapointe, Mathieu; Peng, Huashan; Drapeau, Pierre] Univ Montreal, Dept Pathol & Cell Biol, Montreal, PQ H3T 1J4, Canada.
[Champagne, Nathalie; Brustein, Edna; Lapointe, Mathieu; Peng, Huashan; Drapeau, Pierre] Univ Montreal, Grp Rech Syst Nerveux Cent, Montreal, PQ H3T 1J4, Canada.
[Hamdan, Fadi F.; Samuels, Mark E.; S2D Team] Univ Montreal, Ctr Excellence Neurom, CHU St Justine, Res Ctr, Montreal, PQ H3T 1C5, Canada.
[Addington, Anjene M.; Rapoport, Judith L.] NIMH, Child Psychiat Branch, Bethesda, MD 20892 USA.
[DeLisi, Lynn E.] Harvard Univ, Sch Med, Vet Adm Boston Healthcare Syst, Brockton, MA 02301 USA.
[Krebs, Marie-Odile; Mouaffak, Faycal] Univ Paris 05, Lab Pathophysiol Psychiat Dis, U894, Hop St Anne, F-75014 Paris, France.
[Joober, Ridha; Fathalli, Ferid] McGill Univ, Dept Psychiat, Douglas Mental Hlth Univ Inst, Montreal, PQ H4H 1R3, Canada.
[Haghighi, Ali P.; Carbonetto, Salvatore] McGill Univ, Dept Physiol, Montreal, PQ H3G 0B1, Canada.
[Neri, Christian] Ctr Paul Broca, INSERM, U857, F-75014 Paris, France.
[Dube, Marie-Pierre] Univ Montreal, Ctr Rech, Inst Cardiol Montreal, Montreal, PQ H1T 1C8, Canada.
[Dube, Marie-Pierre] Univ Montreal, Dept Pharmacol, Montreal, PQ H1T 1C8, Canada.
[Stone, Eric A.] N Carolina State Univ, Raleigh, NC 27695 USA.
[Awadalla, Philip] Univ Montreal, Res Ctr, CHU St Justine, Montreal, PQ H3T 1C5, Canada.
[Awadalla, Philip] Univ Montreal, Dept Pediat & Biochem, Montreal, PQ H3T 1C5, Canada.
[Barker, Philip A.] McGill Univ, Montreal Neurol Inst, Ctr Neuronal Survival, Montreal, PQ H3A 2B4, Canada.
[Carbonetto, Salvatore] McGill Univ, Ctr Res Neurosci, Ctr Hlth, Montreal Gen Hosp, Montreal, PQ H3G 1A4, Canada.
RP Gauthier, J (reprint author), Univ Montreal, CHU Montreal, Res Ctr, Ctr Excellence Neurom, Montreal, PQ H2L 2W5, Canada.
EM julie.gauthier@crchum.qc.ca; guy.rouleau@umontreal.ca
RI Neri, Christian/F-6729-2013; Dube, Marie-Pierre/B-9364-2008
OI Dube, Marie-Pierre/0000-0001-8442-4393
FU Genome Canada and Genome Quebec; Universite de Montreal for the Synapse
to Disease; Canadian Foundation for Innovation
FX We thank all the families involved in this study. We would like to thank
Dr. Chawki Benkelfat for several helpful discussions. We also
acknowledge the efforts of the members of the Genome Quebec Innovation
Centre Sequencing (Pierre Lepage, Sebastien Brunet, and Hao Fan Yam) and
Bioinformatic (Louis Letourneau and Louis Dumond Joseph) groups. This
work was supported by Genome Canada and Genome Quebec, and received
cofunding from Universite de Montreal for the Synapse to Disease (S2D)
project as well as funding from the Canadian Foundation for Innovation.
G. A. R. holds the Canada Research Chair in Genetics of the Nervous
System; P. D. holds the Canada Research Chair in Neuroscience. A. P. H.
holds the Canada Research Chair in Drosophila Neurobiology. P. A. holds
a career award from the Fonds de la recherche en Sante du Quebec. A
portion of the schizophrenia cohort was collected through the
Collaborative Network for Family Study in Psychiatry (Reseau d'etude
Familiale en Psychiatry), supported by the Fondation Pierre Deniker.
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TC 129
Z9 133
PU NATL ACAD SCIENCES
PI WASHINGTON
PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA
SN 0027-8424
J9 P NATL ACAD SCI USA
JI Proc. Natl. Acad. Sci. U. S. A.
PD APR 27
PY 2010
VL 107
IS 17
BP 7863
EP 7868
DI 10.1073/pnas.0906232107
PG 6
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 588QQ
UT WOS:000277088700048
PM 20385823
ER
PT J
AU Churches, O
Wheelwright, S
Baron-Cohen, S
Ring, H
AF Churches, Owen
Wheelwright, Sally
Baron-Cohen, Simon
Ring, Howard
TI The N170 is not modulated by attention in autism spectrum conditions
SO NEUROREPORT
LA English
DT Article
DE attention; autism; event-related potentials; face processing
ID FUNCTIONING AUTISM; ASPERGERS-SYNDROME; FUSIFORM GYRUS; FACE; CHILDREN;
INDIVIDUALS; RECOGNITION; ACTIVATION; DISORDERS; RESPONSES
AB Face processing deficits are characteristic of autism spectrum conditions. However, event-related potential studies of autism spectrum conditions have found inconsistent results for the face selective N170 component. In this study, 15 adult males with autism spectrum conditions and 15 matched, typically developing controls completed a task in which pictures of faces were either attended to or ignored. In the control group, the N170 was larger when faces were attended to. However, there was no such modulation in the autism spectrum conditions group. This finding helps clarify the results from the earlier event-related potential studies of face processing in autism spectrum conditions and suggests that visual attention does not enhance face processing in autism spectrum conditions as it does in typical development. NeuroReport 21: 399-403 (C) 2010 Wolters Kluwer Health | Lippincott Williams & Wilkins.
C1 [Churches, Owen; Wheelwright, Sally; Baron-Cohen, Simon] Univ Cambridge, Autism Res Ctr, Cambridge CB2 8AH, England.
[Churches, Owen] Univ Cambridge, Cambridge Intellectual & Dev Disabil Res Grp, Dept Psychiat, Cambridge CB2 8AH, England.
RP Churches, O (reprint author), Univ Cambridge, Autism Res Ctr, 2nd Floor,Douglas House,18B Trumpington Rd, Cambridge CB2 8AH, England.
EM ofc20@cam.ac.uk
RI Ring, Howard/G-6684-2011
FU Cambridge Australia Trust; MRC UK
FX OC is supported by the Cambridge Australia Trust. This research was
supported by a grant to SBC from the MRC UK and was conducted in
association with the NIHR CLAHRC for Cambridgeshire and Peterborough NHS
Foundation Trust. The authors would like to thank Michael Lombardo and
Chris Ashwin for their comments on the manuscript. This study was
conducted at Douglas House, 18b Trumpington Road, Cambridge CB2 8AH,
United Kingdom.
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NR 25
TC 14
Z9 14
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0959-4965
J9 NEUROREPORT
JI Neuroreport
PD APR 21
PY 2010
VL 21
IS 6
BP 399
EP 403
DI 10.1097/WNR.0b013e328334311b
PG 5
WC Neurosciences
SC Neurosciences & Neurology
GA 586KK
UT WOS:000276906600002
PM 20848730
ER
PT J
AU Woodruff, CC
Maaske, S
AF Woodruff, Christopher Chad
Maaske, Shannon
TI Action execution engages human mirror neuron system more than action
observation
SO NEUROREPORT
LA English
DT Article
DE mu suppression; electroencephalography; mirror neurons; social
neuroscience
ID PRIMARY MOTOR CORTEX; PREMOTOR CORTEX; AUTISM; EEG; RECOGNITION;
DYSFUNCTION; ACTIVATION; BRAIN
AB The existence of mirror neurons in Macaque monkeys helps to explain many social abilities of primates. Controversy exists, however, over whether human functional brain measures reveal mirror neuron activity. Claims have been made that measures such as electroencephalographic mu suppression reflect a human mirror neuron system such as that seen in monkeys, but more data are needed to support these claims. Here we report significantly greater mu suppression for participants' execution of an action compared with observation of the same action, similar to the pattern seen in monkeys. Current data therefore support the claim that electroencephalographic mu suppression reflects mirror neuron activity in humans. NeuroReport 21: 432-435 (C) 2010 Wolters Kluwer Health | Lippincott Williams & Wilkins.
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TC 9
Z9 9
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0959-4965
J9 NEUROREPORT
JI Neuroreport
PD APR 21
PY 2010
VL 21
IS 6
BP 432
EP 435
DI 10.1097/WNR.0b013e3283385910
PG 4
WC Neurosciences
SC Neurosciences & Neurology
GA 586KK
UT WOS:000276906600008
PM 20220541
ER
PT J
AU McGregor, TL
Misri, A
Bartlett, J
Orabona, G
Friedman, RD
Sexton, D
Maheshwari, S
Morgan, TM
AF McGregor, Tracy L.
Misri, Amit
Bartlett, Jackie
Orabona, Guilherme
Friedman, Richard D.
Sexton, David
Maheshwari, Sunita
Morgan, Thomas M.
TI Consanguinity Mapping of Congenital Heart Disease in a South Indian
Population
SO PLOS ONE
LA English
DT Article
ID VAN-CREVELD-SYNDROME; PARENTAL CONSANGUINITY; GENE; AUTISM; LINKAGE;
DISEQUILIBRIUM; CITRULLINE; CHILDREN; SURGERY; TRAITS
AB Background: Parental consanguinity is a risk factor for congenital heart disease (CHD) worldwide, suggesting that a recessive inheritance model may contribute substantially to CHD. In Bangalore, India, uncle-niece and first cousin marriages are common, presenting the opportunity for an international study involving consanguinity mapping of structural CHD. We sought to explore the recessive model of CHD by conducting a genome-wide linkage analysis utilizing high-density oligonucleotide microarrays and enrolling 83 CHD probands born to unaffected consanguineous parents.
Methodology/Principal Findings: In this linkage scan involving single nucleotide polymorphism (SNP) markers, the threshold for genome-wide statistical significance was set at the standard log-of-odds (LOD) score threshold of 3.3, corresponding to 1995:1 odds in favor of linkage. We identified a maximal single-point LOD score of 3.76 (5754:1 odds) implicating linkage of CHD with the major allele (G) of rs1055061 on chromosome 14 in the HOMEZ gene, a ubiquitously expressed transcription factor containing leucine zipper as well as zinc finger motifs. Re-sequencing of HOMEZ exons did not reveal causative mutations in Indian probands. In addition, genotyping of the linked allele (G) in 325 U. S. CHD cases revealed neither genotypic nor allele frequency differences in varied CHD cases compared to 605 non-CHD controls.
Conclusions/Significance: Despite the statistical power of the consanguinity mapping approach, no single gene of major effect could be convincingly identified in a clinically heterogeneous sample of Indian CHD cases born to consanguineous parents. However, we are unable to exclude the possibility that noncoding regions of HOMEZ may harbor recessive mutations leading to CHD in the Indian population. Further research involving large multinational cohorts of patients with specific subtypes of CHD is needed to attempt replication of the observed linkage peak on chromosome 14. In addition, we anticipate that a targeted re-sequencing approach may complement linkage analysis in future studies of recessive mutation detection in CHD.
C1 [McGregor, Tracy L.; Orabona, Guilherme; Friedman, Richard D.; Morgan, Thomas M.] Vanderbilt Univ, Sch Med, Dept Pediat, Nashville, TN 37212 USA.
[McGregor, Tracy L.; Orabona, Guilherme; Friedman, Richard D.; Morgan, Thomas M.] Monroe Carell Jr Childrens Hosp Vanderbilt, Nashville, TN USA.
[Misri, Amit; Maheshwari, Sunita] Narayana Hrudayalaya Inst Cardiac Sci, Bangalore, Karnataka, India.
[Bartlett, Jackie; Sexton, David; Morgan, Thomas M.] Vanderbilt Univ, Med Ctr, Dept Mol Physiol & Biophys, Ctr Human Genet Res, Nashville, TN USA.
RP McGregor, TL (reprint author), Vanderbilt Univ, Sch Med, Dept Pediat, Nashville, TN 37212 USA.
EM thomas.morgan@vanderbilt.edu
RI Morgan, Tom/C-3478-2012
FU Children's Discovery Institute
FX This work was funded by the Children's Discovery Institute
(http://www.childrensdiscovery.org/). The funders had no role in study
design, data collection and analysis, decision to publish, or
preparation of the manuscript.
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J9 CELL
JI Cell
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BP 210
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SC Biochemistry & Molecular Biology; Cell Biology
GA 584GF
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PM 20403315
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TI Decreased serum levels of adiponectin in subjects with autism
SO PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
LA English
DT Review
DE Adiponectin; Autism; Inflammatory events; Serum
ID BLOOD-BRAIN-BARRIER; CHILDREN; DISORDERS
AB The neurobiological basis for autism remains poorly understood. We hypothesized that adipokines, such as adiponectin, may play a role in the pathophysiology of autism. In this study, we examined whether serum levels of adiponectin are altered in subjects with autism. We measured serum levels of adiponectin in male subjects with autism (n = 31) and age-matched healthy male subjects (n = 31). The serum levels of adiponectin in the subjects with autism were significantly lower than that of normal control subjects. The serum adiponectin levels in the subjects with autism were negatively correlated with their domain A scores in the Autism Diagnostic Interview Revised, which reflects their impairments in social interaction. This study suggests that decreased levels of serum adiponectin might be implicated in the pathophysiology of autism. (C) 2010 Elsevier Inc. All rights reserved.
C1 [Fujita-Shimizu, Azusa; Nakamura, Kazuhiko; Kajizuka, Masanobu; Shinmura, Chie; Iwata, Yasuhide; Mori, Norio] Hamamatsu Univ Sch Med, Dept Psychiat & Neurol, Hamamatsu, Shizuoka 4313192, Japan.
[Suzuki, Katsuaki; Miyachi, Taishi; Suda, Shiro; Tsuchiya, Kenji J.; Matsumoto, Kaori; Sugihara, Genichi; Iwata, Keiko; Yamamoto, Shigeyuki; Tsujii, Masatsugu; Takei, Nori; Mori, Norio] Hamamatsu Univ Sch Med, Osaka Hamamatsu Joint Res Ctr Child Mental Dev, Hamamatsu, Shizuoka 4313192, Japan.
[Matsuzaki, Hideo] Osaka Univ, Osaka Hamamatsu Joint Res Ctr Child Mental Dev, Grad Sch Med, Osaka, Japan.
[Tsujii, Masatsugu] Chukyo Univ, Fac Sociol, Aichi, Japan.
[Sugiyama, Toshiro] Aichi Childrens Hlth & Med Ctr, Aichi, Japan.
RP Nakamura, K (reprint author), Hamamatsu Univ Sch Med, Dept Psychiat & Neurol, Hamamatsu, Shizuoka 4313192, Japan.
EM nakamura@hama-med.ac.jp
FU Ministry of Education, Culture, Sports, Science, and Technology of Japan
FX This work was supported by Grants-in-Aid for Scientific Research from
the Ministry of Education, Culture, Sports, Science, and Technology of
Japan to Dr. K. Nakamura. We thank Miss Tae Takahashi and Tsuruko Mori
for their technical assistance.
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MULTIPLE-SCLEROSIS; SPATIAL STATISTICS; ASPERGER-SYNDROME;
WORKING-MEMORY; CORPUS-CALLOSUM
AB Diffusion tensor imaging (DTI) studies in adolescents with autism spectrum disorders (ASD) indicate aberrant neurodevelopment of frontal white matter (WM), potentially underlying abnormal social cognition and communication in ASD. Here, we further use tract-based spatial statistics (TBSS) to examine the developmental change of WM skeleton (i.e., the most compact whole-brain WM) during adolescence in ASD. This whole-brain DTI used TBSS measures fractional anisotropy (FA) and longitudinal and radial diffusivities in fifty adolescents, 25 ASD and 25 controls. Results show that adolescents with ASD versus controls had significantly reduced FA in the right posterior limb of internal capsule (increased radial diffusivity distally and reduced longitudinal diffusivity centrally). Adolescents with ASD versus controls (covarying for age and IQ) had significantly greater FA in the frontal lobe (reduced radial diffusivity), right cingulate gyrus (reduced radial diffusivity), bilateral insula (reduced radial diffusivity and increased longitudinal diffusivity), right superior temporal gyrus (reduced radial diffusivity), and bilateral middle cerebellar peduncle (reduced radial diffusivity). Notably, a significant interaction with age by group Was found in the right paracentral lobule and bilateral superior frontal gyrus as indicated by an age-related FA gain in the controls whilst an age-related FA loss in the ASD. To our knowledge, this is the first Study to use TBSS to examine WM in individuals with ASD. Our findings indicate that the frontal lobe exhibits abnormal WM microstructure as well as an aberrant neurodevelopment during adolescence in ASD. which support the frontal disconnectivity theory of autism. (C) 2010 Elsevier Inc. All rights reserved.
C1 [Cheng, Yawei; Chen, I-Yun; Fan, Yang-Teng; Lin, Ching-Po] Natl Yang Ming Univ, Inst Neurosci, Taipei 112, Taiwan.
[Cheng, Yawei] Natl Yang Ming Univ, Dept Phys Med & Rehabil, Yilan, Taiwan.
[Chou, Kun-Hsien] Natl Yang Ming Univ, Inst Bioengn, Taipei 112, Taiwan.
[Decety, Jean] Univ Chicago, Dept Psychol, Ctr Cognit & Social Neurosci, Chicago, IL 60637 USA.
[Decety, Jean] Univ Chicago, Dept Psychiat, Ctr Cognit & Social Neurosci, Chicago, IL 60637 USA.
RP Lin, CP (reprint author), Natl Yang Ming Univ, Inst Neurosci, 155 Li Nong St,Sec 2, Taipei 112, Taiwan.
EM cplin@ym.edu.tw
FU National Science Council [NSC 97-2410-H-010-003-MY2, NSC
98-2923-B-010-001-MY3]; National Yang-Ming University Hospital
[RD2008-015]; National Health Institute of Research [NHRI-EX98-9813EC];
Healthy Department of Taipei City Hospital [97001-62-020]
FX The study was in part sponsored by the National Science Council (NSC
97-2410-H-010-003-MY2; NSC 98-2923-B-010-001-MY3), the National
Yang-Ming University Hospital (RD2008-015), the National Health
Institute of Research (NHRI-EX98-9813EC) and the Healthy Department of
Taipei City Hospital (97001-62-020). The authors thank the children and
parents who participated in this study.
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World Health Organization, 1994, INT CLASS DIS
NR 106
TC 90
Z9 92
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 1053-8119
J9 NEUROIMAGE
JI Neuroimage
PD APR 15
PY 2010
VL 50
IS 3
BP 873
EP 882
DI 10.1016/j.neuroimage.2010.01.011
PG 10
WC Neurosciences; Neuroimaging; Radiology, Nuclear Medicine & Medical
Imaging
SC Neurosciences & Neurology; Radiology, Nuclear Medicine & Medical Imaging
GA 566YA
UT WOS:000275408200003
PM 20074650
ER
PT J
AU Pavlova, M
Guerreschi, M
Lutzenberger, W
Sokolov, AN
Krageloh-Mann, I
AF Pavlova, Marina
Guerreschi, Michele
Lutzenberger, Werner
Sokolov, Alexander N.
Kraegeloh-Mann, Ingeborg
TI Cortical response to social interaction is affected by gender
SO NEUROIMAGE
LA English
DT Article
DE Visual social perception; Cortical activity; Magnetoencephalography
(MEG); Induced gamma oscillations; Gender differences; Heider-and-Simmel
animations
ID SUPERIOR TEMPORAL SULCUS; BIOLOGICAL MOTION PERCEPTION; AUTISM SPECTRUM
DISORDERS; DECISION-MAKING; OSCILLATORY ACTIVITY; BRAIN CONNECTIVITY;
ANIMATED SHAPES; SEX-DIFFERENCES; MIRROR SYSTEM; MENTAL STATES
AB The ability of humans to predict and explain other people's actions is of immense value for adaptive behavior and nonverbal communication. Gender differences are often evident in the comprehension of social signals, but the underlying neurobiological basis for these differences is unclear. Combining visual psychophysics with an analysis of neuromagnetic activity, we assessed gender effects an the induced oscillatory response to visual social interaction revealed by motion. A robust difference in the induced gamma response was found between females and males over the left prefrontal cortex, a region implicated in perceptual decision making. The induced gamma neuromagnetic response peaked earlier in females than in males. Moreover, it appears that females anticipate social interaction predicting others' actions ahead of their realization, whereas males require accumulation of more sensory evidence for proper social decisions. The findings reflect gender-dependent modes in cortical processing of visually acquired social information. Contrary to popular wisdom, the Outcome of this Study indicates that gender effects are not evident in the neural circuitry underpinning visual social perception, but in the regions engaged in perceptual decision making. (C) 2009 Elsevier Inc. All rights reserved.
C1 [Pavlova, Marina; Guerreschi, Michele; Kraegeloh-Mann, Ingeborg] Univ Tubingen, Dev Cognit & Social Neurosci Unit, Dept Paediat Neurol & Child Dev, Childrens Hosp,Sch Med, D-72076 Tubingen, Germany.
[Pavlova, Marina; Lutzenberger, Werner] Univ Tubingen, Sch Med, Inst Med Psychol & Behav Neurobiol, MEG Ctr, D-72076 Tubingen, Germany.
[Guerreschi, Michele] Univ Padua, Dept Gen Psychol, Padua, Italy.
[Sokolov, Alexander N.] Univ Tubingen, Sch Med, Low Vis Clin, D-72076 Tubingen, Germany.
[Sokolov, Alexander N.] Univ Tubingen, Sch Med, Res Lab, Ctr Ophthalmol, D-72076 Tubingen, Germany.
RP Pavlova, M (reprint author), Univ Tubingen, Dev Cognit & Social Neurosci Unit, Dept Paediat Neurol & Child Dev, Childrens Hosp,Sch Med, Hoppe Seyler Str 1, D-72076 Tubingen, Germany.
EM marina.pavlova@uni-tuebingen.de
FU Else Kroner-Fresenius-Stiftung [P63/2008]
FX We thank the participants for their kind cooperation, and Jurgen Dax at
the MEG Center of the University of Tubingen Medical School for
substantial technical assistance. This work was supported by the Else
Kroner-Fresenius-Stiftung (research grant P63/2008 to M.P.). This paper
is devoted to the memory of Werner Lutzenberger who passed away on
November 22, 2008.
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NR 55
TC 10
Z9 10
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 1053-8119
J9 NEUROIMAGE
JI Neuroimage
PD APR 15
PY 2010
VL 50
IS 3
BP 1327
EP 1332
DI 10.1016/j.neuroimage.2009.12.096
PG 6
WC Neurosciences; Neuroimaging; Radiology, Nuclear Medicine & Medical
Imaging
SC Neurosciences & Neurology; Radiology, Nuclear Medicine & Medical Imaging
GA 566YA
UT WOS:000275408200047
PM 20056153
ER
PT J
AU Blundell, J
Kaeser, PS
Sudhof, TC
Powell, CM
AF Blundell, Jacqueline
Kaeser, Pascal S.
Sudhof, Thomas C.
Powell, Craig M.
TI RIM1 alpha and Interacting Proteins Involved in Presynaptic Plasticity
Mediate Prepulse Inhibition and Additional Behaviors Linked to
Schizophrenia
SO JOURNAL OF NEUROSCIENCE
LA English
DT Article
ID AUTISM SPECTRUM DISORDER; LONG-TERM PLASTICITY; PREFRONTAL CORTEX;
NEUROTRANSMITTER RELEASE; KNOCKOUT MICE; SYNAPSIN-II; ANIMAL-MODEL;
ACTIVE ZONE; ANTIPSYCHOTIC TREATMENT; SYNAPTIC PLASTICITY
AB Several presynaptic proteins involved in neurotransmitter release in the CNS have been implicated in schizophrenia in human clinical genetic studies, in postmortem studies, and in studies of putative animal models of schizophrenia. The presynaptic protein RIM1 alpha mediates presynaptic plasticity and cognitive function. We now demonstrate that mice deficient in RIM1 alpha exhibit abnormalities in multiple schizophrenia-relevant behavioral tasks including prepulse inhibition, response to psychotomimetic drugs, and social interaction. These schizophrenia-relevant behavioral findings are relatively selective to RIM1 alpha-deficient mice, as mice bearing mutations in the RIM1 alpha binding partners Rab3A or synaptotagmin 1 only show decreased prepulse inhibition. In addition to RIM1 alpha's involvement in multiple behavioral abnormalities, these data suggest that alterations in presynaptic forms of short-term plasticity are linked to alterations in prepulse inhibition, a measure of sensorimotor gating.
C1 [Blundell, Jacqueline; Powell, Craig M.] Univ Texas SW Med Ctr Dallas, Dept Neurol, Dallas, TX 75390 USA.
[Blundell, Jacqueline; Powell, Craig M.] Univ Texas SW Med Ctr Dallas, Dept Psychiat, Dallas, TX 75390 USA.
[Kaeser, Pascal S.; Sudhof, Thomas C.] Stanford Univ, Dept Cellular & Mol Physiol, Palo Alto, CA 94304 USA.
[Kaeser, Pascal S.; Sudhof, Thomas C.] Stanford Univ, Howard Hughes Med Inst, Palo Alto, CA 94304 USA.
RP Powell, CM (reprint author), 5323 Harry Hines Blvd, Dallas, TX 75390 USA.
EM craig.powell@utsouthwestern.edu
FU National Alliance for Research on Schizophrenia and Depression; National
Institute of Mental Health; National Institute of Child Health and Human
Development; Howard Hughes Medical Institute; Hartwell Foundation
FX This work was supported by grants from the National Alliance for
Research on Schizophrenia and Depression (C.M.P.; Constance and Stephen
Lieber Investigator, P.S.K.), the National Institute of Mental Health
(C.M.P., T.C.S.), the National Institute of Child Health and Human
Development (C.M.P.), the Howard Hughes Medical Institute (T.C.S.), and
the Hartwell Foundation (C.M.P.). T.C.S.and P.S.K. supplied the mice,
C.M.P. conceived and designed the experiments, C.M.P.and J.B.performed
the experiments, C.M.P. performed statistical analysis, and C.M.P.wrote
the paper with input from J.B., P.S.K., and T.C.S.We thank current
members of the Powell lab for critical reading of this manuscript.
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NR 96
TC 14
Z9 14
PU SOC NEUROSCIENCE
PI WASHINGTON
PA 11 DUPONT CIRCLE, NW, STE 500, WASHINGTON, DC 20036 USA
SN 0270-6474
J9 J NEUROSCI
JI J. Neurosci.
PD APR 14
PY 2010
VL 30
IS 15
BP 5326
EP 5333
DI 10.1523/JNEUROSCI.0328-10.2010
PG 8
WC Neurosciences
SC Neurosciences & Neurology
GA 583NS
UT WOS:000276685100020
PM 20392954
ER
PT J
AU Maezawa, I
Jin, LW
AF Maezawa, Izumi
Jin, Lee-Way
TI Rett Syndrome Microglia Damage Dendrites and Synapses by the Elevated
Release of Glutamate
SO JOURNAL OF NEUROSCIENCE
LA English
DT Article
ID AUTISM-SPECTRUM DISORDERS; X-CHROMOSOME INACTIVATION; CPG-BINDING
PROTEIN-2; NEURONAL CELL-DEATH; MOUSE MODEL; IN-VIVO; TRANSCRIPTIONAL
REPRESSOR; CONNEXIN HEMICHANNELS; MOLECULAR-MECHANISMS; SYNAPTIC
PLASTICITY
AB MECP2, an X-linked gene encoding the epigenetic factor methyl-CpG-binding protein-2, is mutated in Rett syndrome (RTT) and aberrantly expressed in autism. Most children affected by RTT are heterozygous Mecp2(-/+) females whose brain function is impaired postnatally due to MeCP2 deficiency. Recent studies suggest a role of glia in causing neuronal dysfunction via a non-cell-autonomous effect in RTT. Here we report a potent neurotoxic activity in the conditioned medium (CM) obtained from Mecp2-null microglia. Hippocampal neurons treated with CM from Mecp2-null microglia showed an abnormal stunted and beaded dendritic morphology, and signs of microtubule disruption and damage of postsynaptic glutamatergic components within 24 h. We identified that the toxic factor in the CM is glutamate, because (1) Mecp2-null microglia released a fivefold higher level of glutamate, (2) blockage of microglial glutamate synthesis by a glutaminase inhibitor abolished the neurotoxic activity, (3) blockage of microglial glutamate release by gap junction hemichannel blockers abolished the neurotoxic activity, and (4) glutamate receptor antagonists blocked the neurotoxicity of the Mecp2-null microglia CM. Wefurther identified that increased levels of glutaminase and connexin 32 in Mecp2-null microglia are responsible for increased glutamate production and release, respectively. In contrast, theCMfrom highly pure Mecp2-null astrocyte cultures showed no toxic effect. Our results suggest that microglia may influence the onset and progression of RTT and that microglia glutamate synthesis or release could be a therapeutic target for RTT.
C1 [Jin, Lee-Way] Univ Calif Davis, Med Ctr, Dept Pathol & Lab Med, MIND Inst, Sacramento, CA 95817 USA.
RP Jin, LW (reprint author), Univ Calif Davis, Med Ctr, Dept Pathol & Lab Med, MIND Inst, 2805 50th St, Sacramento, CA 95817 USA.
EM Lee-Way.Jin@ucdmc.ucdavis.edu
FU University of California Davis
FX This work was funded by the University of California Davis M.I.N.D.
(Medical Investigation of Neurodevelopmental Disorders) Institute. We
thank Dr. Janine LaSalle for helpful comments on this manuscript.
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NR 75
TC 104
Z9 110
PU SOC NEUROSCIENCE
PI WASHINGTON
PA 11 DUPONT CIRCLE, NW, STE 500, WASHINGTON, DC 20036 USA
SN 0270-6474
J9 J NEUROSCI
JI J. Neurosci.
PD APR 14
PY 2010
VL 30
IS 15
BP 5346
EP 5356
DI 10.1523/JNEUROSCI.5966-09.2010
PG 11
WC Neurosciences
SC Neurosciences & Neurology
GA 583NS
UT WOS:000276685100022
PM 20392956
ER
PT J
AU Raff, M
AF Raff, Martin
TI Video Q&A: What is autism? - A personal view
SO BMC BIOLOGY
LA English
DT Editorial Material
ID DISORDERS; CHILDREN
C1 UCL, MRC LMCB, London WC1E 6BT, England.
RP Raff, M (reprint author), UCL, MRC LMCB, Gordon St, London WC1E 6BT, England.
EM m.raff@ucl.ac.uk
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PU BIOMED CENTRAL LTD
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PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1741-7007
J9 BMC BIOL
JI BMC Biol.
PD APR 12
PY 2010
VL 8
AR 42
DI 10.1186/1741-7007-8-42
PG 4
WC Biology
SC Life Sciences & Biomedicine - Other Topics
GA 601IX
UT WOS:000278052900003
PM 20385034
ER
PT J
AU Hess, J
Matson, J
Neal, D
Mahan, S
Fodstad, J
Bamburg, J
Holloway, J
AF Hess, Julie
Matson, Johnny
Neal, Daniene
Mahan, Sara
Fodstad, Jill
Bamburg, Jay
Holloway, Jodie
TI A Comparison of Psychotropic Drug Side Effect Profiles in Adults
Diagnosed With Intellectual Disabilities and Autism Spectrum Disorders
SO JOURNAL OF MENTAL HEALTH RESEARCH IN INTELLECTUAL DISABILITIES
LA English
DT Article
DE autism spectrum disorders; drug side effects; Matson Evaluation of Drug
Side Effects (MEDS); psychotropic medication; intellectual disability
AB Forty-eight adults diagnosed with intellectual disabilities and Autistic Disorder or Pervasive Developmental Disorder-Not Otherwise Specified were examined with regard to psychotropic medication side effects. Participants were divided into 4 groups: no psychotropic medication group (n = 9); atypical antipsychotic medication group (n = 13); atypical antipsychotic and antiepileptic drug group (AEDs/mood stabilizers; n = 13); and a group of individuals receiving atypical antipsychotic medication, AEDs/mood stabilizers, and anxiolytics (n = 13). Those participants not currently prescribed any psychotropic medications evinced the fewest side effects. Participants prescribed psychotropic medication across multiple classes evinced more side effects. Thus, persons receiving atypical antipsychotic medication, AEDs/mood stabilizers, and anxiolytics had the greatest number of side effects. More specifically, the greatest number of side effects pertained to the CNS-Parkinsonism/Dyskinesia subscale.
C1 [Hess, Julie; Matson, Johnny; Neal, Daniene; Mahan, Sara; Fodstad, Jill] Louisiana State Univ, Dept Psychol, Baton Rouge, LA 70803 USA.
[Bamburg, Jay; Holloway, Jodie] Pinecrest Supports & Serv Ctr, Pineville, LA USA.
RP Matson, J (reprint author), Louisiana State Univ, Dept Psychol, 234 Audubon Hall, Baton Rouge, LA 70803 USA.
EM johnmatson@aol.com
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Tabachnick B., 2007, USING MULTIVARIATE S, V5th
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NR 38
TC 3
Z9 3
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND
SN 1931-5864
EI 1931-5872
J9 J MENT HEALTH RES IN
JI J. Ment. Health Res. Intellect. Disabil.
PD APR 9
PY 2010
VL 3
IS 2
BP 85
EP 96
DI 10.1080/19315861003690588
PG 12
WC Education, Special; Psychiatry; Rehabilitation
SC Education & Educational Research; Psychiatry; Rehabilitation
GA V37ZW
UT WOS:000209314700002
ER
PT J
AU Jonsson, L
Ljunggren, E
Bremer, A
Pedersen, C
Landen, M
Thuresson, K
Giacobini, M
Melke, J
AF Jonsson, Lina
Ljunggren, Elin
Bremer, Anna
Pedersen, Christin
Landen, Mikael
Thuresson, Kent
Giacobini, MaiBritt
Melke, Jonas
TI Mutation screening of melatonin-related genes in patients with autism
spectrum disorders
SO BMC MEDICAL GENOMICS
LA English
DT Article
ID CHILDREN; SLEEP; ASMT; TWIN
AB Background: One consistent finding in autism spectrum disorders (ASD) is a decreased level of the pineal gland hormone melatonin and it has recently been demonstrated that this decrease to a large extent is due to low activity of the acetylserotonin O-methyltransferase (ASMT), the last enzyme in the melatonin synthesis pathway. Moreover, mutations in the ASMT gene have been identified, including a splice site mutation, that were associated with low ASMT activity and melatonin secretion, suggesting that the low ASMT activity observed in autism is, at least partly, due to variation within the ASMT gene.
Methods: In the present study, we have investigated all the genes involved in the melatonin pathway by mutation screening of AA-NAT (arylalkylamine N-acetyltransferase), ASMT, MTNR1A, MTNR1B (melatonin receptor 1A and 1B) and GPR50 (G protein-coupled receptor 50), encoding both synthesis enzymes and the three main receptors of melatonin, in 109 patients with autism spectrum disorders (ASD). A cohort of 188 subjects from the general population was used as a comparison group and was genotyped for the variants identified in the patient sample.
Results: Several rare variants were identified in patients with ASD, including the previously reported splice site mutation in ASMT (IVS5+2T>C). Of the variants affecting protein sequence, only the V124I in the MTNR1B gene was absent in our comparison group. However, mutations were found in upstream regulatory regions in three of the genes investigated, ASMT, MTNR1A, and MTNR1B.
Conclusions: Our report of another ASD patient carrying the splice site mutation IVS5+2T> C, in ASMT further supports an involvement of this gene in autism. Moreover, our results also suggest that other melatonin related genes might be interesting candidates for further investigation in the search for genes involved in autism spectrum disorders and related neurobehavioral phenotypes. However, further studies of the novel variants identified in this study are warranted to shed light on their potential role in the pathophysiology of these disorders.
C1 [Jonsson, Lina; Ljunggren, Elin; Pedersen, Christin; Melke, Jonas] Gothenburg Univ, Dept Pharmacol, Inst Neurosci & Physiol, S-41124 Gothenburg, Sweden.
[Bremer, Anna; Giacobini, MaiBritt] Karolinska Inst, Dept Mol Med & Surg, Stockholm, Sweden.
[Landen, Mikael] Karolinska Inst, Stockholm Ctr Psychiat Res, Stockholm, Sweden.
[Thuresson, Kent] Univ Gothenburg, Dept Psychiat & Neurochem, Inst Neurosci & Physiol, Neuropsychiat Unit,Molndals Hosp, Gothenburg, Sweden.
RP Melke, J (reprint author), Gothenburg Univ, Dept Pharmacol, Inst Neurosci & Physiol, S-41124 Gothenburg, Sweden.
EM jonas.melke@pharm.gu.se
FU Swedish Research Council [2004-6588]; Wilhelm and Martina Lundgren
Foundation; Magnus Bergvall Foundation; Ahlens Foundation; Frimurarna
Barnhuset Foundation; Linnea and Josef Carlsson Foundation; Knut and
Alice Wallenberg Foundation
FX We are grateful to the patients and their relatives who have made this
study possible. Technicians Gunilla Bourghardt and Inger Oscarsson and
nurse Carina Algede are warmly thanked for their skilful assistance, and
professor Goran Holm for collecting and characterizing the control
samples. This work has been supported by the Swedish Research Council
(2004-6588), the Wilhelm and Martina Lundgren Foundation, the Magnus
Bergvall Foundation, the Ahlens Foundation, the Frimurarna Barnhuset
Foundation and the Linnea and Josef Carlsson Foundation. We also would
like to thank the SWEGENE Goteborg Genomics Core Facility platform,
funded by a grant from the Knut and Alice Wallenberg Foundation.
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NR 27
TC 29
Z9 29
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1755-8794
J9 BMC MED GENOMICS
JI BMC Med. Genomics
PD APR 8
PY 2010
VL 3
AR 10
DI 10.1186/1755-8794-3-10
PG 7
WC Genetics & Heredity
SC Genetics & Heredity
GA 588LU
UT WOS:000277072500001
PM 20377855
ER
PT J
AU Nakano, T
Ota, H
Kato, N
Kitazawa, S
AF Nakano, Tamami
Ota, Haruhisa
Kato, Nobumasa
Kitazawa, Shigeru
TI Deficit in visual temporal integration in autism spectrum disorders
SO PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
LA English
DT Article
DE autism; slit viewing; weak central coherence
ID EYE GAZE; CHILDREN; PERCEPTION
AB Individuals with autism spectrum disorders (ASD) are superior in processing local features. Frith and Happe conceptualize this cognitive bias as 'weak central coherence', implying that a local enhancement derives from a weakness in integrating local elements into a coherent whole. The suggested deficit has been challenged, however, because individuals with ASD were not found to be inferior to normal controls in holistic perception. In these opposing studies, however, subjects were encouraged to ignore local features and attend to the whole. Therefore, no one has directly tested whether individuals with ASD are able to integrate local elements over time into a whole image. Here, we report a weakness of individuals with ASD in naming familiar objects moved behind a narrow slit, which was worsened by the absence of local salient features. The results indicate that individuals with ASD have a clear deficit in integrating local visual information over time into a global whole, providing direct evidence for the weak central coherence hypothesis.
C1 [Nakano, Tamami; Kitazawa, Shigeru] Juntendo Univ, Sch Med, Dept Physiol, Tokyo 113, Japan.
[Nakano, Tamami; Ota, Haruhisa; Kato, Nobumasa; Kitazawa, Shigeru] Japan Sci & Technol Agcy, CREST, Saitama, Japan.
[Nakano, Tamami] Japan Soc Promot Sci, Tokyo, Japan.
[Ota, Haruhisa; Kato, Nobumasa] Showa Univ, Sch Med, Dept Psychiat, Tokyo 142, Japan.
RP Nakano, T (reprint author), Juntendo Univ, Sch Med, Dept Physiol, Tokyo 113, Japan.
EM tanakano@juntendo.ac.jp
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NR 20
TC 13
Z9 13
PU ROYAL SOC
PI LONDON
PA 6-9 CARLTON HOUSE TERRACE, LONDON SW1Y 5AG, ENGLAND
SN 0962-8452
J9 P R SOC B
JI Proc. R. Soc. B-Biol. Sci.
PD APR 7
PY 2010
VL 277
IS 1684
BP 1027
EP 1030
DI 10.1098/rspb.2009.1713
PG 4
WC Biology; Ecology; Evolutionary Biology
SC Life Sciences & Biomedicine - Other Topics; Environmental Sciences &
Ecology; Evolutionary Biology
GA 559WH
UT WOS:000274858500007
PM 19955150
ER
PT J
AU McGary, KL
Park, TJ
Woods, JO
Cha, HJ
Wallingford, JB
Marcotte, EM
AF McGary, Kriston L.
Park, Tae Joo
Woods, John O.
Cha, Hye Ji
Wallingford, John B.
Marcotte, Edward M.
TI Systematic discovery of nonobvious human disease models through
orthologous phenotypes
SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF
AMERICA
LA English
DT Article
DE angiogenesis; bioinformatics; evolution; gene-phenotype associations;
homology
ID SACCHAROMYCES-CEREVISIAE; MICE; PROTEINS; DATABASE; NETWORK; YEAST;
DEFECTS; ELEGANS; GENES
AB Biologists have long used model organisms to study human diseases, particularly when the model bears a close resemblance to the disease. We present a method that quantitatively and systematically identifies nonobvious equivalences between mutant phenotypes in different species, based on overlapping sets of orthologous genes from human, mouse, yeast, worm, and plant (212,542 gene-phenotype associations). These orthologous phenotypes, or phenologs, predict unique genes associated with diseases. Our method suggests a yeast model for angiogenesis defects, a worm model for breast cancer, mouse models of autism, and a plant model for the neural crest defects associated with Waardenburg syndrome, among others. Using these models, we show that SOX13 regulates angiogenesis, and that SEC23IP is a likely Waardenburg gene. Phenologs reveal functionally coherent, evolutionarily conserved gene networks-many predating the plant-animal divergence-capable of identifying candidate disease genes.
C1 [McGary, Kriston L.; Park, Tae Joo; Woods, John O.; Cha, Hye Ji; Wallingford, John B.; Marcotte, Edward M.] Univ Texas Austin, Inst Cellular & Mol Biol, Ctr Syst & Synthet Biol, Austin, TX 78712 USA.
[Park, Tae Joo; Wallingford, John B.] Univ Texas Austin, Howard Hughes Med Inst, Austin, TX 78712 USA.
[Park, Tae Joo; Wallingford, John B.] Univ Texas Austin, Dept Mol Cell & Dev Biol, Austin, TX 78712 USA.
[Marcotte, Edward M.] Univ Texas Austin, Dept Chem & Biochem, Austin, TX 78712 USA.
RP Marcotte, EM (reprint author), Univ Texas Austin, Inst Cellular & Mol Biol, Ctr Syst & Synthet Biol, Austin, TX 78712 USA.
EM marcotte@icmb.utexas.edu
RI Park, Tae Joo/G-1460-2011
FU Texas Advanced Research Program; National Science Foundation; National
Institutes of Health; Welch Foundation [F-1515]; National Institute of
General Medical Sciences and The March of Dimes (; Texas Institute for
Drug and Diagnostic Development
FX We thank Greg Weiss for Fig. 1A, and Andrew Fraser, Andrew Ellington,
and Jim Bull for critical discussion. This work was supported by grants
from the Texas Advanced Research Program, the National Science
Foundation, the National Institutes of Health, and the Welch Foundation
(F-1515), and a Packard Fellowship (to E. M. M.), a National Science
Foundation graduate fellowship (to J.O.W.), and grants from the National
Institute of General Medical Sciences and The March of Dimes (to
J.B.W.). J.B.W. is an Early Career Scientist of the Howard Hughes
Medical Institute. T.J.P. is supported by a Postdoctoral Research
Initiative Seed Grant from the Texas Institute for Drug and Diagnostic
Development.
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NR 28
TC 101
Z9 103
PU NATL ACAD SCIENCES
PI WASHINGTON
PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA
SN 0027-8424
J9 P NATL ACAD SCI USA
JI Proc. Natl. Acad. Sci. U. S. A.
PD APR 6
PY 2010
VL 107
IS 14
BP 6544
EP 6549
DI 10.1073/pnas.0910200107
PG 6
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 579MH
UT WOS:000276374400075
PM 20308572
ER
PT J
AU Annangudi, SP
Luszpak, AE
Kim, SH
Ren, SF
Hatcher, NG
Weiler, IJ
Thornley, KT
Kile, BM
Wightman, RM
Greenough, WT
Sweedler, JV
AF Annangudi, Suresh P.
Luszpak, Agatha E.
Kim, Soong Ho
Ren, Shifang
Hatcher, Nathan G.
Weiler, Ivan Jeanne
Thornley, Keith T.
Kile, Brian M.
Wightman, R. Mark
Greenough, William T.
Sweedler, Jonathan V.
TI Neuropeptide Release Is Impaired in a Mouse Model of Fragile X Mental
Retardation Syndrome
SO ACS CHEMICAL NEUROSCIENCE
LA English
DT Article
DE Neuropeptide release; Rab3A; dense-core vesicles; Fragile X syndrome;
synaptic remodeling; dendrites; mass spectrometry; synaptic transmission
ID LONG-TERM POTENTIATION; MASS-SPECTROMETRY; KNOCKOUT MICE; SYNAPTIC
PLASTICITY; NERVE-TERMINALS; BRAIN; CELLS; PEPTIDES; PROTEIN; VESICLES
AB Fragile X syndrome (FXS), an inherited disorder characterized by mental retardation and autism-like behaviors, is caused by the failure to transcribe the gene for fragile X mental retardation protein (FMRP), a translational regulator and transporter of select mRNAs. FXS model mice (Find KO mice) exhibit impaired neuropeptide release. Release of biogenic amines does not differ between wild-type (WT) and FmrI KO mice. Rab3A, an mRNA cargo of FMRP involved in the recruitment of vesicles, is decreased by similar to 50% in synaptoneurosomes of FmrI KO mice; however, the number of dense-core vesicles (DCVs) does not differ between WT and FmrI KO mice. Therefore, deficits associated with FXS may reflect this aberrant vesicle release, specifically involving docking and fusion of peptidergic DCVs, and may lead to defective maturation and maintenance of synaptic connections.
C1 [Annangudi, Suresh P.; Ren, Shifang; Hatcher, Nathan G.; Sweedler, Jonathan V.] Univ Illinois, Dept Chem, Urbana, IL 61801 USA.
[Annangudi, Suresh P.; Luszpak, Agatha E.; Kim, Soong Ho; Ren, Shifang; Hatcher, Nathan G.; Weiler, Ivan Jeanne; Greenough, William T.; Sweedler, Jonathan V.] Univ Illinois, Beckman Inst, Urbana, IL 61801 USA.
[Luszpak, Agatha E.; Kim, Soong Ho; Weiler, Ivan Jeanne; Greenough, William T.; Sweedler, Jonathan V.] Univ Illinois, Neurosci Program, Urbana, IL 61801 USA.
[Luszpak, Agatha E.] Univ Illinois, Med Scholars Program, Urbana, IL 61801 USA.
[Greenough, William T.] Univ Illinois, Dept Psychol, Urbana, IL 61801 USA.
[Greenough, William T.] Univ Illinois, Dept Psychiat, Urbana, IL 61801 USA.
[Greenough, William T.] Univ Illinois, Dept Cell & Struct Biol, Urbana, IL 61801 USA.
[Thornley, Keith T.; Kile, Brian M.; Wightman, R. Mark] Univ N Carolina, Dept Chem, Chapel Hill, NC 27514 USA.
RP Sweedler, JV (reprint author), Univ Illinois, Dept Chem, 600 S Mathews, Urbana, IL 61801 USA.
EM wgreenou@illinois.edu; jsweedle@illinois.edu
RI Sweedler, Jonathan/A-9405-2009
OI Sweedler, Jonathan/0000-0003-3107-9922
FU National Institute on Drug Abuse (NIDA) [P30DA018310, DA017940];
National Institute of Neurological Disorders and Stroke (NINDS)
[NS031609, NS038879]; National Institute of Mental Health (NIMH)
[MH035321]
FX The projected described was supported by the National Institute on Drug
Abuse (NIDA) under Award Nos. P30DA018310 and DA017940, the National
Institute of Neurological Disorders and Stroke (NINDS) under Award Nos.
NS031609 and NS038879, and the National Institute of Mental Health
(NIMH) under Award No, MH035321. The content is solely the
responsibility of the authors and does not necessarily represent the
official views of the NIDA, NINDS, NIMH, or the National Institutes of
Health.
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NR 48
TC 9
Z9 9
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1948-7193
J9 ACS CHEM NEUROSCI
JI ACS Chem. Neurosci.
PD APR
PY 2010
VL 1
IS 4
BP 306
EP 314
DI 10.1021/cn900036x
PG 9
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Neurosciences
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Neurosciences
& Neurology
GA 600JE
UT WOS:000277981200007
ER
PT J
AU Wuang, YP
Wang, CC
Huang, MH
Su, CY
AF Wuang, Yee-Pay
Wang, Chih-Chung
Huang, Mao-Hsiung
Su, Chwen-Yng
TI The Effectiveness of Simulated Developmental Horse-Riding Program in
Children With Autism
SO ADAPTED PHYSICAL ACTIVITY QUARTERLY
LA English
DT Article
ID MANIPULATION; RELIABILITY; VALIDITY; GRIP
AB This study investigated the effectiveness of a 20-week Simulated Developmental Horse-Riding Program (SDHRP) by using an innovative exercise equipment (Joba (R)) on the motor proficiency and sensory integrative functions in 60 children with autism (age: 6 years, 5 months to 8 years, 9 months). In the first phase of 20 weeks, 30 children received the SDHRP in addition to their regular occupational therapy while another 30 children received regular occupational therapy only. The arrangement was reversed in the second phase of another 20 weeks. Children with autism in this study showed improved motor proficiency and sensory integrative functions after 20-week SDHRP (p < .01). In addition, the therapeutic effect appeared to be sustained for at least 24 weeks (6 months).
C1 [Wuang, Yee-Pay; Su, Chwen-Yng] Kaohsiung Med Univ, Dept Occupat Therapy, Kaohsiung, Taiwan.
[Wang, Chih-Chung; Huang, Mao-Hsiung] Kaohsiung Med Univ, Dept Phys Med & Rehabil, Chung Ho Mem Hosp, Kaohsiung, Taiwan.
RP Wuang, YP (reprint author), Kaohsiung Med Univ, Dept Occupat Therapy, Kaohsiung, Taiwan.
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NR 37
TC 13
Z9 13
PU HUMAN KINETICS PUBL INC
PI CHAMPAIGN
PA 1607 N MARKET ST, PO BOX 5076, CHAMPAIGN, IL 61820-2200 USA
SN 0736-5829
J9 ADAPT PHYS ACT Q
JI Adapt. Phys. Act. Q.
PD APR
PY 2010
VL 27
IS 2
BP 113
EP 126
PG 14
WC Rehabilitation; Sport Sciences
SC Rehabilitation; Sport Sciences
GA 580RF
UT WOS:000276466400003
PM 20440023
ER
PT J
AU Bradstreet, JJ
Smith, S
Baral, M
Rossignol, DA
AF Bradstreet, James Jeffrey
Smith, Scott
Baral, Matthew
Rossignol, Daniel A.
TI Biomarker-Guided Interventions of Clinically Relevant Conditions
Associated with Autism Spectrum Disorders and Attention Deficit
Hyperactivity Disorder
SO ALTERNATIVE MEDICINE REVIEW
LA English
DT Review
DE autism; autistic; ADD; ADHD; ASD; attention deficit; biomarkers
ID INFLAMMATORY-BOWEL-DISEASE; PERVASIVE DEVELOPMENTAL DISORDER; INTENSIVE
BEHAVIORAL TREATMENT; ENVIRONMENTAL MERCURY RELEASE; OXIDATIVE STRESS;
DEFICIT/HYPERACTIVITY DISORDER; GASTROINTESTINAL SYMPTOMS;
IRON-DEFICIENCY; MITOCHONDRIAL DYSFUNCTION; FECAL CALPROTECTIN
AB Autism spectrum disorders (ASD) and attention-deficit hyperactivity disorder (ADHD) are common and complex neurodevelopmental conditions. Diagnostic criteria for these conditions have traditionally relied solely on behavioral criteria without consideration for potential biomedical underpinnings. Newer evidence, however, reveals that ASDs are associated with: oxidative stress; decreased methylation capacity; limited production of glutathione; mitochondrial dysfunction; intestinal dysbiosis; increased toxic metal burden; immune dysregulation, characterized by a unique inflammatory bowel disease and immune activation of neuroglial cells; and ongoing brain hypoperfusion. Many of these same problems are common features in children with ADHD. These medical conditions, whether co-morbidities or etiopathogenic, would be expected to have synergistically negative effects on the development, cognition, focus, and attention of affected children. It is likely these biological abnormalities contribute significantly to the behavioral symptoms intrinsic in these diagnoses. However, treatment for these underlying medical disorders is clinically justified, even if no clear immediate behavioral improvements are observed. This article reviews the medical literature and discusses the authors' clinical experience using various biomarkers for measuring oxidative stress, methylation capacity and transsulfuration, immune function, gastrointestinal problems, and toxic metal burden. These biomarkers provide useful guides for selection, efficacy, and sufficiency of biomedical interventions. The use of these biomarkers is of great importance in young children with ADHD or individuals of any age with ASD, because typically they cannot adequately communicate regarding their symptoms. (Altern Med Rev 2010;15(1)15-32)
C1 [Bradstreet, James Jeffrey; Smith, Scott; Rossignol, Daniel A.] Int Child Dev Resource Ctr, Melbourne, FL 32934 USA.
[Bradstreet, James Jeffrey; Baral, Matthew] SW Coll Naturopath Med, Tempe, AZ USA.
[Baral, Matthew] Pediat Med program, Tempe, AZ USA.
RP Bradstreet, JJ (reprint author), Int Child Dev Resource Ctr, 3800 W Eau Gallie Blvd, Melbourne, FL 32934 USA.
EM DrBradstreet@aol.com
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NR 178
TC 20
Z9 20
PU ALTERNATIVE MEDICINE REVIEW, LLC
PI DOVER
PA PO BOX 555, DOVER, ID 83825 USA
SN 1089-5159
J9 ALTERN MED REV
JI Altern. Med. Rev.
PD APR
PY 2010
VL 15
IS 1
BP 15
EP 32
PG 18
WC Integrative & Complementary Medicine; Pharmacology & Pharmacy
SC Integrative & Complementary Medicine; Pharmacology & Pharmacy
GA 595SB
UT WOS:000277632000003
PM 20359266
ER
PT J
AU Erturk, O
Bilguvar, K
Korkmaz, B
Bayri, Y
Bayrakli, F
Arlier, Z
Ozturk, AK
Yalcinkaya, C
Tuysuz, B
State, MW
Gunel, M
AF Erturk, Ozdem
Bilguvar, Kaya
Korkmaz, Baris
Bayri, Yasar
Bayrakli, Fatih
Arlier, Zulfikar
Ozturk, Ali K.
Yalcinkaya, Cengiz
Tuysuz, Beyhan
State, Matthew W.
Gunel, Murat
TI A Patient With Duchenne Muscular Dystrophy and Autism Demonstrates a
Hemizygous Deletion Affecting Dystrophin
SO AMERICAN JOURNAL OF MEDICAL GENETICS PART A
LA English
DT Letter
ID FRAGILE-X-SYNDROME; INTELLECTUAL IMPAIRMENT; SPECTRUM DISORDER;
GENETICS; ISOFORM; DEFICIT; MALES; MODEL; MICE
C1 [Gunel, Murat] Yale Univ, Sch Med, Dept Neurosurg & Neurobiol, Program Neurogenet, New Haven, CT 06510 USA.
[Bilguvar, Kaya; Bayri, Yasar; Bayrakli, Fatih; Arlier, Zulfikar; Ozturk, Ali K.; Gunel, Murat] Yale Univ, Sch Med, Dept Neurosurg, New Haven, CT 06510 USA.
[Erturk, Ozdem; Korkmaz, Baris; Yalcinkaya, Cengiz] Istanbul Univ, Cerrahpasa Fac Med, Dept Neurol, Div Child Neurol, Istanbul, Turkey.
[Tuysuz, Beyhan] Istanbul Univ, Cerrahpasa Fac Med, Dept Pediat, Div Genet, Istanbul, Turkey.
[State, Matthew W.; Gunel, Murat] Yale Univ, Dept Genet, New Haven, CT 06510 USA.
[State, Matthew W.] Yale Univ, Sch Med, Ctr Child Study, New Haven, CT 06510 USA.
[Gunel, Murat] Yale Univ, Sch Med, Dept Neurobiol, New Haven, CT 06510 USA.
RP Gunel, M (reprint author), Yale Univ, Sch Med, Dept Neurosurg & Neurobiol, Program Neurogenet, 333 Cedar St,Tompkins 4, New Haven, CT 06510 USA.
EM murat.gunel@yale.edu
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NR 24
TC 3
Z9 3
PU WILEY-LISS
PI HOBOKEN
PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 1552-4825
J9 AM J MED GENET A
JI Am. J. Med. Genet. A
PD APR
PY 2010
VL 152A
IS 4
BP 1039
EP 1042
DI 10.1002/ajmg.a.33312
PG 4
WC Genetics & Heredity
SC Genetics & Heredity
GA 584LS
UT WOS:000276754000041
PM 20358624
ER
PT J
AU Burdick, KE
DeRosse, P
Kane, JM
Lencz, T
Malhotra, AK
AF Burdick, Katherine E.
DeRosse, Pamela
Kane, John M.
Lencz, Todd
Malhotra, Anil K.
TI Association of Genetic Variation in the MET Proto-Oncogene With
Schizophrenia and General Cognitive Ability
SO AMERICAN JOURNAL OF PSYCHIATRY
LA English
DT Article
ID AUTISM SPECTRUM DISORDER; HEPATOCYTE GROWTH-FACTOR; TUMOR-SUPPRESSOR
GENE; INTERNEURON DEVELOPMENT; CANCER-RISK; POPULATION; SUSCEPTIBILITY;
DISRUPTION; MEDICATION; RELATIVES
AB Objective: Despite increased exposure to cancer risk factors, several studies have demonstrated a lower incidence of cancer in schizophrenia patients than in the general population. Lower cancer rates in first-degree relatives of schizophrenia patients suggest that the inverse relationship between cancer and schizophrenia may be related to genetic factors. Few studies of schizophrenia have focused on cancer-related genes. The MET proto-oncogene is primarily linked to tumor metastasis, but MET is also involved in neurodevelopment and influences risk for autism. Thus, MET may be of particular interest as a candidate gene for neuropsychiatric diseases with a developmental etiology, including schizophrenia.
Method: The authors examined the relationship between 21 single-nucleotide polymorphisms in MET and schizophrenia in 173 Caucasian patients and 137 comparison subjects. They then genotyped a second independent sample (107 patients and 112 comparison subjects) for replication. Finally, they tested for MET's effects on general cognitive ability (g).
Results: In the initial cohort, the authors identified four haplotype blocks and found one block to be globally associated with schizophrenia. In block 3, the most common haplotype was over-represented in comparison subjects (frequency, 47%) relative to schizophrenia patients (frequency, 33%) (p=4.0x10(-4); odds ratio=0.56). The authors replicated the block 3 finding in the second sample with similar frequencies: 46% in comparison subjects and 36% in schizophrenia patients (p=0.03; odds ratio=0.66). Moreover, the protective haplotype was associated with a higher g in the combined comparison sample.
Conclusions: These data suggest that MET variation influences schizophrenia risk and neurocognition, supporting a neurodevelopmental role across CNS-relevant phenotypes. These results add to the growing evidence suggesting an intriguing relationship between cancer-related genes and schizophrenia susceptibility.
C1 [Burdick, Katherine E.] Zucker Hillside Hosp, N Shore Long Isl Jewish Hlth Syst, Dept Psychiat Res, Glen Oaks, NY 11004 USA.
Albert Einstein Coll Med, Dept Psychiat, New York, NY USA.
Feinstein Inst Med Res, Manhasset, NY USA.
RP Burdick, KE (reprint author), Zucker Hillside Hosp, N Shore Long Isl Jewish Hlth Syst, Dept Psychiat Res, 75-59 263rd St, Glen Oaks, NY 11004 USA.
EM kburdick@lij.edu
RI Burdick, Katherine/G-6124-2012
FU Bristol-Myers Squibb; Eli Lilly; Janssen Pharmaceuticals; Pfizer
FX Drs. Burdick and DeRosse report no financial relationships with
commercial interests. Dr. Kane has served as a consultant or speaker or
on advisory boards for Abbott, AstraZeneca, Bristol-Myers Squibb,
Clinical Data, Inc., Eli Lilly, Janssen, Johnson & Johnson PRD,
Lundbeck, Otsuka, Pfizer, Vanda Pharmaceuticals, and Wyeth
Pharmaceuticals. Dr. Lencz has served as a consultant to Eli Lilly,
GoldenHelix, Clinical Data, Inc., and InforMed Insights. Dr. Malhotra
has served as a consultant or speaker for Bristol-Myers Squibb, Clinical
Data, Inc., Eli Lilly, AstraZeneca, and Vanda Pharmaceuticals and has
received research support from Bristol-Myers Squibb, Eli Lilly, Janssen
Pharmaceuticals, and Pfizer.
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NR 40
TC 17
Z9 17
PU AMER PSYCHIATRIC PUBLISHING, INC
PI ARLINGTON
PA 1000 WILSON BOULEVARD, STE 1825, ARLINGTON, VA 22209-3901 USA
SN 0002-953X
J9 AM J PSYCHIAT
JI Am. J. Psychiat.
PD APR
PY 2010
VL 167
IS 4
BP 436
EP 443
DI 10.1176/appi.ajp.2009.09050615
PG 8
WC Psychiatry
SC Psychiatry
GA 577LE
UT WOS:000276223800014
PM 20080979
ER
PT J
AU Grozeva, D
Kirov, G
Ivanov, D
Jones, IR
Jones, L
Green, EK
St Clair, DM
Young, AH
Ferrier, N
Farmer, AE
McGuffin, P
Holmans, PA
Owen, MJ
O'Donovan, MC
Craddock, N
AF Grozeva, Detelina
Kirov, George
Ivanov, Dobril
Jones, Ian R.
Jones, Lisa
Green, Elaine K.
St Clair, David M.
Young, Allan H.
Ferrier, Nicol
Farmer, Anne E.
McGuffin, Peter
Holmans, Peter A.
Owen, Michael J.
O'Donovan, Michael C.
Craddock, Nick
CA Wellcome Trust Case Control
TI Rare Copy Number Variants A Point of Rarity in Genetic Risk for Bipolar
Disorder and Schizophrenia
SO ARCHIVES OF GENERAL PSYCHIATRY
LA English
DT Article
ID GENOME-WIDE ASSOCIATION; CARDIO-FACIAL SYNDROME; INCREASE RISK;
MICRODELETION; 22Q11.2; MICRODUPLICATION; PHENOTYPES; DELETIONS;
DISEASE; AUTISM
AB Context: Recent studies suggest that copy number variation in the human genome is extensive and may play an important role in susceptibility to disease, including neuropsychiatric disorders such as schizophrenia and autism. The possible involvement of copy number variants (CNVs) in bipolar disorder has received little attention to date.
Objectives: To determine whether large (> 100 000 base pairs) and rare (found in < 1% of the population) CNVs are associated with susceptibility to bipolar disorder and to compare with findings in schizophrenia.
Design: A genome-wide survey of large, rare CNVs in a case-control sample using a high-density microarray.
Setting: The Wellcome Trust Case Control Consortium.
Participants: There were 1697 cases of bipolar disorder and 2806 nonpsychiatric controls. All participants were white UK residents.
Main Outcome Measures: Overall load of CNVs and presence of rare CNVs.
Results: The burden of CNVs in bipolar disorder was not increased compared with controls and was significantly less than in schizophrenia cases. The CNVs previously implicated in the etiology of schizophrenia were not more common in cases with bipolar disorder.
Conclusions: Schizophrenia and bipolar disorder differ with respect to CNV burden in general and association with specific CNVs in particular. Our data are consistent with the possibility that possession of large, rare deletions may modify the phenotype in those at risk of psychosis: those possessing such events are more likely to be diagnosed as having schizophrenia, and those without them are more likely to be diagnosed as having bipolar disorder.
C1 [Grozeva, Detelina; Kirov, George; Ivanov, Dobril; Jones, Ian R.; Green, Elaine K.; Holmans, Peter A.; Owen, Michael J.; O'Donovan, Michael C.; Craddock, Nick] Cardiff Univ, Sch Med, Ctr Neuropsychiat Genet & Genom, MRC, Cardiff CF14 4XN, S Glam, Wales.
[Ivanov, Dobril; Holmans, Peter A.] Cardiff Univ, Sch Med, Biostat & Bioinformat Unit, Cardiff CF14 4XN, S Glam, Wales.
[Jones, Lisa] Univ Birmingham, Dept Psychiat, Natl Ctr Mental Hlth, Birmingham, W Midlands, England.
[St Clair, David M.] Univ Aberdeen, Inst Med Sci, Aberdeen, Scotland.
[Young, Allan H.; Ferrier, Nicol] Royal Victoria Infirm, Sch Neurol Neurobiol & Psychiat, Newcastle Upon Tyne NE1 4LP, Tyne & Wear, England.
[Young, Allan H.] Univ British Columbia, Inst Mental Hlth, Vancouver, BC V5Z 1M9, Canada.
[Farmer, Anne E.; McGuffin, Peter] Kings Coll London, Inst Psychiat, Social Genet & Dev Psychiat Ctr, London WC2R 2LS, England.
RP Craddock, N (reprint author), Cardiff Univ, Sch Med, Ctr Neuropsychiat Genet & Genom, MRC, Cardiff CF14 4XN, S Glam, Wales.
EM craddockn@cardiff.ac.uk
RI Brown, Matthew/E-5749-2010; McGuffin, Peter/A-1565-2012; Breen,
Gerome/A-5540-2010; Holmans, Peter/F-4518-2015
OI Brown, Matthew/0000-0003-0538-8211; McGuffin, Peter/0000-0002-9888-2907;
Breen, Gerome/0000-0003-2053-1792; Holmans, Peter/0000-0003-0870-9412
FU Wellcome Trust; Medical Research Council
FX Funding for recruitment and phenotype assessment was provided by the
Wellcome Trust and the Medical Research Council. The genotype analyses
were funded by the Wellcome Trust and undertaken within the context of
the Wellcome Trust Case Control Consortium. Online-Only Material: The
supplementary Results section, eTables, and eFigures are available at
http://www.archgenpsychiatry.com.
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Weiss LA, 2008, NEW ENGL J MED, V358, P667, DOI 10.1056/NEJMoa075974
Wheeler DA, 2008, NATURE, V452, P872, DOI 10.1038/nature06884
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NR 41
TC 97
Z9 101
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 515 N STATE ST, CHICAGO, IL 60654-0946 USA
SN 0003-990X
J9 ARCH GEN PSYCHIAT
JI Arch. Gen. Psychiatry
PD APR
PY 2010
VL 67
IS 4
BP 318
EP 327
PG 10
WC Psychiatry
SC Psychiatry
GA 578RM
UT WOS:000276312800002
PM 20368508
ER
PT J
AU Dziobek, I
Bahnemann, M
Convit, A
Heekeren, HR
AF Dziobek, Isabel
Bahnemann, Markus
Convit, Antonio
Heekeren, Hauke R.
TI The Role of the Fusiform-Amygdala System in the Pathophysiology of
Autism
SO ARCHIVES OF GENERAL PSYCHIATRY
LA English
DT Article
ID CORTICAL AREAS TE; SPECTRUM DISORDERS; CEREBRAL-CORTEX; FACE AREA;
ASPERGER-SYNDROME; BRAIN-DEVELOPMENT; VISUAL AWARENESS; SOCIAL
COGNITION; MACAQUE MONKEY; PERCEPTION
AB Context: Autism is a condition of unknown origin with well-documented impairments in social perception and cognition.
Objective: To assess the relevance of the fusiform-amygdala system to the pathophysiology of autism spectrum conditions.
Design: Cross-sectional case-control study.
Setting: University hospital.
Participants: A total of 27 adults with autism spectrum conditions and 29 age-, sex-, and intelligence quotient-matched typically developed healthy controls. Patients were assessed according to DSM-IV criteria using the Autism Diagnostic Interview-Revised.
Interventions: We applied an automated measurement to estimate fusiform gyrus cortical thickness and a manual tracing method to obtain amygdala volumes. We analyzed volumetric covariance among these brain regions and assessed the functional relevance of anatomical findings by analyzing correlations with emotional face processing performance.
Main Outcome Measures: Fusiform gyrus cortical thickness, amygdala volume, emotional face processing.
Results: We found a specific local increase in cortical thickness of the fusiform gyrus and associated impairments in face processing in individuals with autism. Anatomical covariance between amygdala volume and the increase in fusiform gyrus local thickness was significantly smaller in the group with autism spectrum conditions.
Conclusions: Our data provide the first anatomical evidence of an abnormal amygdala-fusiform system and its behavioral relevance to face-processing deficits in autism spectrum conditions. In light of recent evidence of the involvement of the fusiform gyrus and amygdala in social perception as well as the areas of social cognition and emotional awareness, all of which are relevant to autism, our findings might represent a core pathophysiological mechanism of autism.
C1 [Dziobek, Isabel; Bahnemann, Markus; Heekeren, Hauke R.] Max Planck Inst Human Dev, D-14195 Berlin, Germany.
[Dziobek, Isabel; Heekeren, Hauke R.] Max Planck Inst Human Cognit & Brain Sci, Leipzig, Germany.
[Dziobek, Isabel; Heekeren, Hauke R.] Free Univ Berlin, Berlin, Germany.
[Bahnemann, Markus; Heekeren, Hauke R.] Charite, Berlin NeuroImaging Ctr, D-13353 Berlin, Germany.
[Convit, Antonio] NYU, Sch Med, Ctr Brain Hlth, New York, NY USA.
[Convit, Antonio] Nathan S Kline Inst Psychiat Res, Orangeburg, NY 10962 USA.
RP Heekeren, HR (reprint author), Max Planck Inst Human Dev, Lentzeallee 94, D-14195 Berlin, Germany.
EM heekeren@mpib-berlin.mpg.de
RI Heekeren, Hauke/B-7739-2008
OI Heekeren, Hauke/0000-0001-7912-6826
FU National Alliance for Autism Research; Organization for Autism Research;
German Federal Ministry for Research; Max Planck Society
FX This study was supported by a grant from the National Alliance for
Autism Research; Organization for Autism Research; German Federal
Ministry for Research; and the Max Planck Society.
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NR 76
TC 40
Z9 42
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 515 N STATE ST, CHICAGO, IL 60654-0946 USA
SN 0003-990X
J9 ARCH GEN PSYCHIAT
JI Arch. Gen. Psychiatry
PD APR
PY 2010
VL 67
IS 4
BP 397
EP 405
PG 9
WC Psychiatry
SC Psychiatry
GA 578RM
UT WOS:000276312800010
PM 20368515
ER
PT J
AU Abrahams, BS
Geschwind, DH
AF Abrahams, Brett S.
Geschwind, Daniel H.
TI Connecting Genes to Brain in the Autism Spectrum Disorders
SO ARCHIVES OF NEUROLOGY
LA English
DT Review
ID DEVELOPMENTAL LANGUAGE DISORDER; TUBEROUS SCLEROSIS COMPLEX;
FRAGILE-X-SYNDROME; RETT-SYNDROME; HEAD CIRCUMFERENCE; JOUBERT-SYNDROME;
MENTAL-RETARDATION; MONOZYGOTIC TWINS; FRONTAL-CORTEX; NEURON NUMBER
AB T he autism spectrum disorders (ASDs) are a complex group of neuropsychiatric conditions involving language, social communication, and mental flexibility. Here, we attempt to place recent genetic advances within a developmental and anatomical context. Recent progress in identifying ASD candidate genes supports involvement of multiple brain regions, including the frontal lobes, anterior temporal lobes, caudate, and cerebellum. Understanding genetic data within an anatomical context will be critical to explain how individual risk factors operate to shape phenotypic presentation in patients. Arch Neurol. 2010; 67(4): 395-399
C1 [Geschwind, Daniel H.] Univ Calif Los Angeles, Neurogenet Program, Dept Neurol, David Geffen Sch Med, Los Angeles, CA 90095 USA.
[Geschwind, Daniel H.] Univ Calif Los Angeles, Program Neurobehav Genet, Dept Neurol, David Geffen Sch Med, Los Angeles, CA 90095 USA.
Univ Calif Los Angeles, David Geffen Sch Med, Semel Inst Neurosci & Behav, Los Angeles, CA 90095 USA.
RP Geschwind, DH (reprint author), Univ Calif Los Angeles, Neurogenet Program, Dept Neurol, David Geffen Sch Med, Gonda Bldg 2506, Los Angeles, CA 90095 USA.
EM dhg@mednet.ucla.edu
FU Autism Speaks; Cure Autism Now Foundation; National Institute of Mental
Health [U54 MH68172, P50 HD055784, R01 MH64547, R37 MH60233]
FX The work in the Geschwind laboratory is supported by Autism Speaks, the
Cure Autism Now Foundation, and grants U54 MH68172, P50 HD055784, R01
MH64547, and R37 MH60233 from the National Institute of Mental Health.
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NR 49
TC 66
Z9 68
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 515 N STATE ST, CHICAGO, IL 60610-0946 USA
SN 0003-9942
J9 ARCH NEUROL-CHICAGO
JI Arch. Neurol.
PD APR
PY 2010
VL 67
IS 4
BP 395
EP 399
PG 5
WC Clinical Neurology
SC Neurosciences & Neurology
GA 581XQ
UT WOS:000276559500003
PM 20385903
ER
PT J
AU de los Reyes, EC
AF de los Reyes, Emily C.
TI Autism and Immunizations Separating Fact From Fiction
SO ARCHIVES OF NEUROLOGY
LA English
DT Editorial Material
ID THIMEROSAL-CONTAINING VACCINES; NEURODEVELOPMENTAL DISORDERS; CAUSAL
ASSOCIATION; MECP2 DYSFUNCTION; MEASLES; EXPOSURE; CHILDREN; INFANTS;
MUMPS
C1 Ohio State Univ, Coll Med, Div Child Neurol, Columbus, OH 43205 USA.
RP de los Reyes, EC (reprint author), Ohio State Univ, Coll Med, Div Child Neurol, 700 Childrens Dr, Columbus, OH 43205 USA.
EM emily.delosreyes@nationwidechildrens.org
RI De Los Reyes, Emily/E-2959-2011
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NR 22
TC 1
Z9 1
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 515 N STATE ST, CHICAGO, IL 60610-0946 USA
SN 0003-9942
J9 ARCH NEUROL-CHICAGO
JI Arch. Neurol.
PD APR
PY 2010
VL 67
IS 4
BP 490
EP 492
PG 3
WC Clinical Neurology
SC Neurosciences & Neurology
GA 581XQ
UT WOS:000276559500018
PM 20385917
ER
PT J
AU Allen-Brady, K
Cannon, D
Robison, R
McMahon, WM
Coon, H
AF Allen-Brady, Kristina
Cannon, Dale
Robison, Reid
McMahon, William M.
Coon, Hilary
TI Unified Theory of Autism Revisited: Linkage Evidence Points to
Chromosome X using a High-Risk Subset of AGRE Families
SO AUTISM RESEARCH
LA English
DT Article
DE autism spectrum disorder; genetic linkage; dominant model; pedigree
structure; chromosome Xp
ID LINKED MENTAL-RETARDATION; NEURONAL CALCIUM SENSOR-1; IL1RAPL1 GENE;
UTAH PEDIGREES; LOD SCORES; HETEROGENEITY; DISSECTION; DISORDERS;
MUTATION; LOCI
AB Zhao et al. [2007] in their "Unified Theory of Autism" hypothesized that incidence of autism in males could be explained by essentially two types of family structures: majority of autism cases are from low-risk autism families with de novo mutations, and a minority of cases are from high-risk multiplex families, where risk to male offspring approximates 50% consistent with a dominant model and high penetrance. Using the Autism Genetic Resource Exchange (AGRE) data set, Zhao et al. identified 86 high-risk families with likely dominant transmission. As genotype data are now available for many members of the AGRE resource, the objective of this manuscript was to determine if dominant linkage evidence for an autism predisposition gene exists in these 86 high-risk families. HumanHap550K Illumina SNP data were available for 92% of 455 total family members in these 86 high-risk families. We performed a linkage analysis using a pruned subset of markers where markers in high linkage disequilibrium were removed. We observed a single suggestive peak (maximum LOD 2.01, maximum HLOD 2.08) under a dominant model on chromosome Xp22.11-p21.2 that encompasses the 1L1RAPL1 gene. Mutations or deletions in 1L1RAPL1 have been previously reported in three families with autism. In our study, 11 families contributed nominally (P<0.05, HLOD > 0.588) to the chromosome X peak. These results demonstrate that identification of a more homogeneous subset of autism cases, which was based on family structure in this study, may help to identify, localize and further our understanding of autism predisposition genes.
C1 [Allen-Brady, Kristina; Cannon, Dale; Robison, Reid; McMahon, William M.; Coon, Hilary] Univ Utah, Dept Psychiat, Utah Autism Res Project, Salt Lake City, UT 84108 USA.
[McMahon, William M.; Coon, Hilary] Univ Utah, Inst Brain, Salt Lake City, UT 84108 USA.
RP Allen-Brady, K (reprint author), Univ Utah, Dept Psychiat, Utah Autism Res Project, 650 Komas Dr,Suite 206, Salt Lake City, UT 84108 USA.
EM Kristina.allen@utah.edu
FU [R01 MH069359]
FX We thank Jim Farnham for his assistance with generation of the linkage
subset of markers. This work was supported by R01 MH069359. We
gratefully acknowledge the resources provided by the Autism Genetic
Resource Exchange (AGRE) Consortium* and the participating AGRE
families. The Autism Genetic Resource Exchange is a program of Autism
Speaks and is supported, in part, by grant 1U24MH081810 from the
National Institute of Mental Health to Clara M. Lajonchere (PI).
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NR 28
TC 6
Z9 6
PU JOHN WILEY & SONS INC
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 1939-3792
J9 AUTISM RES
JI Autism Res.
PD APR
PY 2010
VL 3
IS 2
BP 47
EP 52
DI 10.1002/aur.119
PG 6
WC Behavioral Sciences; Psychology, Developmental
SC Behavioral Sciences; Psychology
GA 590ED
UT WOS:000277206100001
PM 20437600
ER
PT J
AU Scott-Van Zeeland, AA
Dapretto, M
Ghahremani, DG
Poldrack, RA
Bookheimer, SY
AF Scott-Van Zeeland, Ashley A.
Dapretto, Mirella
Ghahremani, Dara G.
Poldrack, Russell A.
Bookheimer, Susan Y.
TI Reward Processing in Autism
SO AUTISM RESEARCH
LA English
DT Article
DE functional MRI (fMRI); social cognition; reward; learning
ID SOCIAL COGNITION; ORBITOFRONTAL CORTEX; DIAGNOSTIC INTERVIEW; REPETITIVE
BEHAVIORS; BASAL GANGLIA; FMRI; OXYTOCIN; BRAIN; SCHIZOPHRENIA;
PREDICTION
AB The social motivation hypothesis of autism posits that infants with autism do not experience social stimuli as rewarding, thereby leading to a cascade of potentially negative consequences for later development. While possible downstream effects of this hypothesis such as altered face and voice processing have been examined, there has not been a direct investigation of social reward processing in autism. Here we use functional magnetic resonance imaging to examine social and monetary rewarded implicit learning in children with and without autism spectrum disorders (ASD). Sixteen males with ASD and sixteen age- and IQ-matched typically developing (TO) males were scanned while performing two versions of a rewarded implicit learning task. In addition to examining responses to reward, we investigated the neural circuitry supporting rewarded learning and the relationship between these factors and social development. We found diminished neural responses to both social and monetary rewards in ASD, with a pronounced reduction in response to social rewards (SR). Children with ASD also demonstrated a further deficit in frontostriatal response during social, but not monetary, rewarded learning. Moreover, we show a relationship between ventral striatum activity and social reciprocity in TD children. Together, these data support the hypothesis that children with ASD have diminished neural responses to SR, and that this deficit relates to social learning impairments.
C1 [Scott-Van Zeeland, Ashley A.; Poldrack, Russell A.; Bookheimer, Susan Y.] Univ Calif Los Angeles, Ctr Cognit Neurosci, Semel Inst Neurosci & Human Behav, Los Angeles, CA USA.
[Dapretto, Mirella; Ghahremani, Dara G.; Poldrack, Russell A.; Bookheimer, Susan Y.] Univ Calif Los Angeles, Dept Psychiat & Biobehav Sci, Los Angeles, CA 90024 USA.
[Dapretto, Mirella; Poldrack, Russell A.; Bookheimer, Susan Y.] Univ Calif Los Angeles, Brain Res Inst, Los Angeles, CA 90024 USA.
[Poldrack, Russell A.; Bookheimer, Susan Y.] Univ Calif Los Angeles, Dept Psychol, Los Angeles, CA 90024 USA.
[Scott-Van Zeeland, Ashley A.] Univ Calif Los Angeles, Neurosci Interdept Program, Los Angeles, CA USA.
[Scott-Van Zeeland, Ashley A.] Scripps Translat Sci Inst, La Jolla, CA USA.
[Poldrack, Russell A.] Univ Texas Austin, Dept Psychol, Austin, TX 78712 USA.
RP Bookheimer, SY (reprint author), Semel Inst Psychiat & Biobehav Sci, 760 Westwood Plaza,C8-881, Los Angeles, CA 90095 USA.
EM sbook@ucla.edu
FU NICHD [P01 HD035470]; NIH/NICHO IPSO [HD0557841, R01 HD065280-01, UL1
12R025774]
FX This work was in part supported by grants from the NICHD (P01 HD035470
and NIH/NICHO IPSO HD055784; 1R01 HD065280-01; UL1 12R025774), the
National Alliance for Autism Research, Autism Speaks, Whitehall
Foundation, as well as by the Training Program in Neurobehavioral
Genetics (T32 MH073526), and a NRSA predoctoral fellowship (F31
MH079645) and Dickinson Fellowship to Ashley Scott-Van Zeeland. The
authors wish to thank J. Cohen for her technical assistance. For
generous support the authors also wish to thank the Brain Mapping
Medical Research Organization, Brain Mapping Support Foundation,
PiersonLovelace Foundation, Ahmanson Foundation, William M. and Linda R.
Dietel Philanthropic Fund at the Northern Piedmont Community Foundation,
Tamkin Foundation, Jennifer Jones-Simon Foundation, Capital Group
Companies Charitable Foundation, Robson Family and Northstar Fund. The
project described was in part also supported by grants (121212169,
RR13642 and RI200865) from the National Center for Research Resources
(NCRR), a component of the National Institutes of Health (NTH); its
contents are solely the responsibility of the authors and do not
necessarily represent the official views of NCR or NWT.
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NR 60
TC 73
Z9 74
PU JOHN WILEY & SONS INC
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 1939-3792
J9 AUTISM RES
JI Autism Res.
PD APR
PY 2010
VL 3
IS 2
BP 53
EP 67
DI 10.1002/aur.122
PG 15
WC Behavioral Sciences; Psychology, Developmental
SC Behavioral Sciences; Psychology
GA 590ED
UT WOS:000277206100002
PM 20437601
ER
PT J
AU Travers, BG
Klinger, MR
Mussey, JL
Klinger, LG
AF Travers, Brittany G.
Klinger, Mark R.
Mussey, Joanna L.
Klinger, Laura G.
TI Motor-Linked Implicit Learning in Persons with Autism Spectrum Disorders
SO AUTISM RESEARCH
LA English
DT Article
DE neuropsychology; implicit learning; sequence learning; autism spectrum
disorders; serial response task
ID SKILL; DISSOCIATION; EQUIVALENCE; ATTENTION; KNOWLEDGE; EXPLICIT;
DEFICIT; SPEED; TIME
AB Fifteen adolescents and young adults with high-functioning autism spectrum disorders (ASD) and 18 age- and IQ-matched adults with typical development (TD) completed a serial reaction time task (SRT) to examine possible motor-linked implicit learning impairments in persons with ASD. Measures were taken to decrease the role of explicit learning in the SRT. Results showed that participants with AS!) demonstrated intact motor-linked implicit learning. Furthermore, the motor-linked implicit learning appeared to take place at a similar rate across trials in the group with ASD compared to the group with TD. These results suggest that persons with AS!) are successful in implicit learning of motor-linked behavior. The results of this study, coupled with past findings, suggest that people with AS!) may be able to learn motor movements without conscious awareness, especially if the individual is older and is learning fine motor sequences.
C1 [Travers, Brittany G.; Klinger, Mark R.; Mussey, Joanna L.; Klinger, Laura G.] Univ Alabama, Dept Psychol, Tuscaloosa, AL 35487 USA.
RP Travers, BG (reprint author), Univ Alabama, Dept Psychol, Box 870348, Tuscaloosa, AL 35487 USA.
EM bgtravers@crimson.ua.edu
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NR 36
TC 11
Z9 11
PU JOHN WILEY & SONS INC
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 1939-3792
J9 AUTISM RES
JI Autism Res.
PD APR
PY 2010
VL 3
IS 2
BP 68
EP 77
DI 10.1002/aur.123
PG 10
WC Behavioral Sciences; Psychology, Developmental
SC Behavioral Sciences; Psychology
GA 590ED
UT WOS:000277206100003
PM 20437602
ER
PT J
AU Boyd, BA
Baranek, GT
Sideris, J
Poe, MD
Watson, LR
Patten, E
Miller, H
AF Boyd, Brian A.
Baranek, Grace T.
Sideris, John
Poe, Michele D.
Watson, Linda R.
Patten, Elena
Miller, Heather
TI Sensory Features and Repetitive Behaviors in Children with Autism and
Developmental Delays
SO AUTISM RESEARCH
LA English
DT Article
DE autism; repetitive behaviors; responses to sensory stimuli; sensory
symptoms
ID OBSESSIVE-COMPULSIVE DISORDER; SPECTRUM DISORDERS; YOUNG-CHILDREN;
TYPICAL DEVELOPMENT; ABNORMALITIES; INTEGRATION; ANNOTATION; ATTENTION;
SYMPTOMS; TODDLERS
AB This study combined parent and observational measures to examine the association between aberrant sensory features and restricted, repetitive behaviors in children with autism (N = 67) and those with developmental delays (N = 42). Confirmatory factor analysis was used to empirically validate three sensory constructs of interest: hyperresponsiveness, hyporesponsiveness, and sensory seeking. Examining the association between the three derived sensory factor scores and scores on the Repetitive Behavior Scales-Revised revealed the co-occurrence of these behaviors in both clinical groups. Specifically, high levels of hyperresponsive behaviors predicted high levels of repetitive behaviors, and the relationship between these variables remained the same controlling for mental age. We primarily found non-significant associations between hyporesponsiveness or sensory seeking and repetitive behaviors, with the exception that sensory seeking was associated with ritualistic/sameness behaviors. These findings suggest that shared neurobiological mechanisms may underlie hyperresponsive sensory symptoms and repetitive behaviors and have implications for diagnostic classification as well as intervention.
C1 [Boyd, Brian A.; Baranek, Grace T.; Sideris, John; Poe, Michele D.; Watson, Linda R.; Patten, Elena; Miller, Heather] Univ N Carolina, Chapel Hill, NC USA.
RP Boyd, BA (reprint author), Div Occupat Sci, CB 7122,UNC CH Bondurant Hall, Chapel Hill, NC 27599 USA.
EM brian_boyd@med.unc.edu
RI Poe, Michele/K-6615-2012
OI Poe, Michele/0000-0001-9693-3638
FU National Institute for Child Health and Human Development [R01-HD42168]
FX This research was supported in part by a grant from the National
Institute for Child Health and Human Development (R01-HD42168). We thank
the families whose participation made this study possible.
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NR 57
TC 42
Z9 42
PU JOHN WILEY & SONS INC
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 1939-3792
J9 AUTISM RES
JI Autism Res.
PD APR
PY 2010
VL 3
IS 2
BP 78
EP 87
DI 10.1002/aur.124
PG 10
WC Behavioral Sciences; Psychology, Developmental
SC Behavioral Sciences; Psychology
GA 590ED
UT WOS:000277206100004
PM 20437603
ER
PT J
AU Best, CA
Minshew, NJ
Strauss, MS
AF Best, Catherine A.
Minshew, Nancy J.
Strauss, Mark S.
TI Gender Discrimination of Eyes and Mouths by Individuals with Autism
SO AUTISM RESEARCH
LA English
DT Article
DE autism; gender discrimination; face perception; facial features
ID HIGH-FUNCTIONING AUTISM; SPECTRUM DISORDERS; FACE; RECOGNITION;
INFORMATION; FIXATION; CHILDREN; GAZE; COMPETENCE; ATTENTION
AB Evidence remains mixed about whether individuals with autism look less to eyes and whether they look more at mouths. Few studies have examined how spontaneous attention to facial features relates to face processing abilities. This study tested the ability to discriminate gender from facial features, namely eyes and mouths, by comparing accuracy scores of 17 children with autism and 15 adults with autism to 17 typically developing children and 15 typically developing adults. Results indicated that all participants regardless of diagnosis discriminated gender more accurately from eyes than from mouths. However, results indicated that compared to adults without autism, adults with autism were significantly worse at discriminating gender from eyes.
C1 [Best, Catherine A.; Strauss, Mark S.] Univ Pittsburgh, Dept Psychol, Pittsburgh, PA 15260 USA.
[Minshew, Nancy J.] Univ Pittsburgh, Sch Med, Dept Psychiat & Neurol, Pittsburgh, PA 15260 USA.
RP Strauss, MS (reprint author), Univ Pittsburgh, Dept Psychol, 210 S Bouquet St, Pittsburgh, PA 15260 USA.
EM strauss@pitt.edu
FU NIH [P01-HD354-69]
FX This research was supported by a NIH Collaborative Program of Excellence
in Autism (CPEA) Grant P01-HD354-69 to Nancy J. Minshew and Mark S.
Strauss. We are grateful to the participants and their families for
making this research possible and to the CPEA staff for their efforts in
recruiting and scheduling participants. We especially thank Holly
Gastgeb and Keiran Rump for their time testing participants.
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NR 33
TC 7
Z9 7
PU JOHN WILEY & SONS INC
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 1939-3792
J9 AUTISM RES
JI Autism Res.
PD APR
PY 2010
VL 3
IS 2
BP 88
EP 93
DI 10.1002/aur.125
PG 6
WC Behavioral Sciences; Psychology, Developmental
SC Behavioral Sciences; Psychology
GA 590ED
UT WOS:000277206100005
PM 20437604
ER
PT J
AU Shelton, JF
Tancredi, DJ
Hertz-Picciotto, I
AF Shelton, Janie F.
Tancredi, Daniel J.
Hertz-Picciotto, Irva
TI Independent and Dependent Contributions of Advanced Maternal and
Paternal Ages to Autism Risk (vol 3, pg 30, 2010)
SO AUTISM RESEARCH
LA English
DT Correction
C1 [Shelton, Janie F.; Hertz-Picciotto, Irva] Univ Calif Davis, Dept Publ Hlth Sci, Davis, CA 95616 USA.
[Tancredi, Daniel J.] Univ Calif Davis, Dept Pediat, Davis, CA 95616 USA.
[Tancredi, Daniel J.] Univ Calif Davis, Ctr Healthcare Policy & Res, Davis, CA 95616 USA.
[Hertz-Picciotto, Irva] UC Davis MIND Inst, Sacramento, CA USA.
RP Shelton, JF (reprint author), Univ Calif Davis, Dept Publ Hlth Sci, MS1C, Davis, CA 95616 USA.
EM jfshelton@ucdavis.edu
CR Shelton JF, 2010, AUTISM RES, V3, P30, DOI 10.1002/aur.116
NR 1
TC 1
Z9 2
PU JOHN WILEY & SONS INC
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 1939-3792
J9 AUTISM RES
JI Autism Res.
PD APR
PY 2010
VL 3
IS 2
BP 98
EP 98
DI 10.1002/aur.135
PG 1
WC Behavioral Sciences; Psychology, Developmental
SC Behavioral Sciences; Psychology
GA 590ED
UT WOS:000277206100006
ER
PT J
AU Arntzen, E
Halstadtro, LB
Bjerke, E
Halstadtro, M
AF Arntzen, Erik
Halstadtro, Lill-Beathe
Bjerke, Eli
Halstadtro, Monica
TI TRAINING AND TESTING MUSIC SKILLS IN A BOY WITH AUTISM USING A
MATCHING-TO-SAMPLE FORMAT
SO BEHAVIORAL INTERVENTIONS
LA English
DT Article
ID STIMULUS-EQUIVALENCE; EMERGENCE; INDIVIDUALS; PROBABILITY; SEQUENCE;
CHILDREN; DESIGN
AB A 16-year old boy with autism was taught music skills using a matching to sample procedure. He was trained and subsequently tested for the formation of four 4-member classes, including different visual music stimuli, and Norwegian and Vietnamese labels for different major and minor chords. Four different stimuli sets were trained both in one-to-many (OTM) and many-to-one (MTO) training structures. Further, we explored if the reaction times to comparison stimuli increased from training to testing. Results showed that the participant formed equivalence classes with music relations. Furthermore, there were small differences only between OTM and MTO with respect to stimulus equivalence responding. The reaction times to comparison stimuli increased from training to testing, and were most pronounced for the equivalence trials. Copyright (C) 2010 John Wiley & Sons, Ltd.
C1 [Arntzen, Erik] Akershus Univ Coll, N-2001 Lillestrom, Norway.
[Halstadtro, Lill-Beathe] St Olavs Hosp, Trondsletten Habilitat Serv, Trondheim, Norway.
[Bjerke, Eli; Halstadtro, Monica] Byasen High Sch, Trondheim, Norway.
RP Arntzen, E (reprint author), Akershus Univ Coll, POB 423, N-2001 Lillestrom, Norway.
EM erik.arntzen@equivalence.net
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ARNTZEN E, PSYCHOL REC IN PRESS
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NR 24
TC 4
Z9 4
PU JOHN WILEY & SONS LTD
PI CHICHESTER
PA THE ATRIUM, SOUTHERN GATE, CHICHESTER PO19 8SQ, W SUSSEX, ENGLAND
SN 1072-0847
J9 BEHAV INTERVENT
JI Behav. Intervent.
PD APR
PY 2010
VL 25
IS 2
BP 129
EP 143
DI 10.1002/bin.301
PG 15
WC Psychology, Clinical
SC Psychology
GA 584XN
UT WOS:000276787700003
ER
PT J
AU Taylor, SA
Anderson, K
Mudford, OC
AF Taylor, Sarah Ann
Anderson, Kerrie
Mudford, Oliver C.
TI EFFECTS OF TEXTUAL RESPONSE PROMPTS FOR ADOLESCENTS IN A SUBSTANCE ABUSE
TREATMENT PROGRAM
SO BEHAVIORAL INTERVENTIONS
LA English
DT Article
ID CHILDREN; AUTISM
AB Adolescents in a drug and alcohol treatment facility had behavioral deficits in having essential items ready for organized group adventure activities. Checklists (i.e., textual response prompts) were introduced. The data from five participants showed increases in the percentage' of required items ready. Generalization was demonstrated across checklists for different activities, across staff and peer leaders, and a different day of the week. Performance was also maintained when the checklist was removed. It was concluded that the use of checklists can be a reliable and efficient strategy to improve performance in adolescents with a substance abuse history. Copyright (C) 2010 John Wiley & Sons, Ltd.
C1 [Taylor, Sarah Ann] Univ Auckland, Dept Psychol, Appl Behav Anal Programme, Auckland, New Zealand.
[Anderson, Kerrie] Odyssey House Trust, Auckland, New Zealand.
RP Taylor, SA (reprint author), Univ Auckland, Dept Psychol, Appl Behav Anal Programme, Tamaki Campus,PB 92019, Auckland, New Zealand.
EM sarahleadley1@gmail.com
CR Barnes GM, 2007, J YOUTH ADOLESCENCE, V36, P697, DOI 10.1007/s10964-006-9075-0
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Hersen M., 1976, SINGLE CASE EXPT DES
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NR 21
TC 2
Z9 2
PU JOHN WILEY & SONS LTD
PI CHICHESTER
PA THE ATRIUM, SOUTHERN GATE, CHICHESTER PO19 8SQ, W SUSSEX, ENGLAND
SN 1072-0847
J9 BEHAV INTERVENT
JI Behav. Intervent.
PD APR
PY 2010
VL 25
IS 2
BP 145
EP 155
DI 10.1002/bin.303
PG 11
WC Psychology, Clinical
SC Psychology
GA 584XN
UT WOS:000276787700004
ER
PT J
AU Thomas, BR
Lafasakis, M
Sturmey, P
AF Thomas, Benjamin R.
Lafasakis, Michael
Sturmey, Peter
TI THE EFFECTS OF PROMPTING, FADING, AND DIFFERENTIAL REINFORCEMENT ON
VOCAL MANDS IN NON-VERBAL PRESCHOOL CHILDREN WITH AUTISM SPECTRUM
DISORDERS
SO BEHAVIORAL INTERVENTIONS
LA English
DT Article
AB There are few procedures to teach non-vocal children vocal mands. This study evaluated the effects of prompting, fading, and differential reinforcement on eye contact, pointing, vocal approximations, independent requests and immature mands in three children with Autism Spectrum Disorders who in baseline emitted almost no independent vocal mands. This procedure resulted in a large and socially valid increase in independent vocal mands, other appropriate responses and near elimination of immature mands. Copyright (C) 2010 John Wiley & Sons, Ltd.
C1 [Sturmey, Peter] CUNY, Queens Coll, Dept Psychol, Flushing, NY 11367 USA.
[Lafasakis, Michael; Sturmey, Peter] CUNY, Grad Ctr, Flushing, NY 11367 USA.
[Lafasakis, Michael] CUNY, Queens Coll, Hosp Clin Home Ctr Inc, Flushing, NY 11367 USA.
RP Sturmey, P (reprint author), CUNY, Queens Coll, Dept Psychol, 65-30 Kissena Blvd, Flushing, NY 11367 USA.
EM psturmey@aol.com
CR Bourret J, 2004, J APPL BEHAV ANAL, V37, P129, DOI 10.1901/jaba.2004.37-129
DRASGOW E, 2008, APPL BEHAV ANAL LANG
Drasgow E, 1998, J APPL BEHAV ANAL, V31, P357, DOI 10.1901/jaba.1998.31-357
Lovaas O. I., 2003, TEACHING INDIVIDUALS
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Thompson RH, 2004, J APPL BEHAV ANAL, V37, P379, DOI 10.1901/jaba.2004.37-379
NR 9
TC 0
Z9 0
PU JOHN WILEY & SONS LTD
PI CHICHESTER
PA THE ATRIUM, SOUTHERN GATE, CHICHESTER PO19 8SQ, W SUSSEX, ENGLAND
SN 1072-0847
J9 BEHAV INTERVENT
JI Behav. Intervent.
PD APR
PY 2010
VL 25
IS 2
BP 157
EP 168
DI 10.1002/bin.300
PG 12
WC Psychology, Clinical
SC Psychology
GA 584XN
UT WOS:000276787700005
ER
PT J
AU Brose, N
O'Connor, V
Skehel, P
AF Brose, Nils
O'Connor, Vincent
Skehel, Paul
TI Synaptopathy: dysfunction of synaptic function?
SO BIOCHEMICAL SOCIETY TRANSACTIONS
LA English
DT Article; Proceedings Paper
CT Conference on Synaptopathies - Dysfunction of Synaptic Function
CY SEP 02-04, 2009
CL Newquay, ENGLAND
DE brain disease; neurodegeneration; synaptic dysfunction; synaptopathy
AB Synaptopathy is an increasingly popular term used to define key features of neurodegenerative and psychiatric disease. It implies that disruptions in synaptic structure and function are potentially the major determinant of such brain diseases. The Synaptopathies: Dysfunction of Synaptic Function Biochemical Society Focused Meeting brought together several invited speakers, supplemented with short communications from young scientists, who addressed this possibility. The talks spanned the full gamut of approaches that brought molecular, cellular, systems and whole-animal experimentation together to address how fundamental synaptic biology was increasingly informing on dysfunction in disease. The disease and models thereof discussed included Alzheimer's disease, prions, Huntington's disease, Parkinson's disease, schizophrenia and autism. The audience were asked to reflect on whether synaptopathy, although attractive and conceptually useful, provided a significant explanation as the cause of these major diseases. The breadth of the meeting reinforced the complexity of these brain diseases, supported the significance of synaptic dysfunction in disease, but left open the issue as to whether the prime cause of these disorders could be resolved as simple synaptic dysfunction. Thus, despite revealing a value of synaptopathy, further investigation will be required to reveal its balance in the cause and effect in each of the major brain diseases.
C1 [Brose, Nils] Max Planck Inst Expt Med, Dept Mol Neurobiol, D-37077 Gottingen, Germany.
[O'Connor, Vincent] Univ Southampton, Sch Biol Sci, Southampton SO16 7PX, Hants, England.
[Skehel, Paul] Ctr Integrat Physiol, Edinburgh EH8 9XD, Midlothian, Scotland.
RP Brose, N (reprint author), Max Planck Inst Expt Med, Dept Mol Neurobiol, Hermann Rein Str 3, D-37077 Gottingen, Germany.
CR Arendt T, 2009, ACTA NEUROPATHOL, V118, P167, DOI 10.1007/s00401-009-0536-x
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Hall J, 2009, TRENDS NEUROSCI, V32, P359, DOI 10.1016/j.tins.2009.01.011
Hanus C, 2008, TRAFFIC, V9, P1437, DOI 10.1111/j.1600-0854.2008.00775.x
Ly CV, 2006, NEUROSCIENTIST, V12, P291, DOI 10.1177/1073858406287661
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Sherrington C. S., 1906, INTEGRATIVE ACTION N
Sutton MA, 2006, CELL, V127, P49, DOI 10.1016/j.cell.2006.09.014
Wojcik SM, 2007, NEURON, V55, P11, DOI 10.1016/j.neuron.2007.06.013
NR 11
TC 13
Z9 13
PU PORTLAND PRESS LTD
PI LONDON
PA THIRD FLOOR, EAGLE HOUSE, 16 PROCTER STREET, LONDON WC1V 6 NX, ENGLAND
SN 0300-5127
J9 BIOCHEM SOC T
JI Biochem. Soc. Trans.
PD APR
PY 2010
VL 38
BP 443
EP 444
DI 10.1042/BST0380443
PN 2
PG 2
WC Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA 585DR
UT WOS:000276805000025
PM 20298199
ER
PT J
AU Cobb, S
Guy, J
Bird, A
AF Cobb, Stuart
Guy, Jacky
Bird, Adrian
TI Reversibility of functional deficits in experimental models of Rett
syndrome
SO BIOCHEMICAL SOCIETY TRANSACTIONS
LA English
DT Article; Proceedings Paper
CT Conference on Synaptopathies - Dysfunction of Synaptic Function
CY SEP 02-04, 2009
CL Newquay, ENGLAND
DE brain-derived neurotrophic factor (BDNF); functional deficit;
nonadrenaine; syndrome (RTT)
ID CPG-BINDING PROTEIN-2; RUBINSTEIN-TAYBI-SYNDROME; SEVERE
MENTAL-RETARDATION; MECP2 MUTANT MICE; MOUSE MODEL; DNA METHYLATION;
ENVIRONMENTAL ENRICHMENT; SYNAPTIC PLASTICITY; TUBEROUS-SCLEROSIS;
NEUROFIBROMATOSIS TYPE-1
AB Mutations in the X-linked MECP2 gene are the primary cause of the severe autism spectrum disorder RTT (Rett syndrome). Deletion of Mecp2 in mice recapitulates many of the overt neurological features seen in humans, and the delayed onset of symptoms is accompanied by deficits in neuronal morphology and synaptic physiology. Recent evidence suggests that reactivation of endogenous Mecp2 in young and adult mice can reverse aspects of RTT-like pathology. In the current perspective, we discuss these findings as well as other genetic, pharmacological and environmental interventions that attempt phenotypic rescue in RTT. We believe these studies provide valuable insights into the tractability of RTT and related conditions and are useful pointers for the development of future therapeutic strategies.
C1 [Cobb, Stuart] Univ Glasgow, Fac Biomed & Life Sci, Glasgow G12 8QQ, Lanark, Scotland.
[Guy, Jacky; Bird, Adrian] Univ Edinburgh, Wellcome Trust Ctr Cell Biol, Edinburgh, Midlothian, Scotland.
RP Cobb, S (reprint author), Univ Glasgow, Fac Biomed & Life Sci, Glasgow G12 8QQ, Lanark, Scotland.
CR Adachi M, 2009, J NEUROSCI, V29, P4218, DOI 10.1523/JNEUROSCI.4225-08.2009
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NR 84
TC 34
Z9 34
PU PORTLAND PRESS LTD
PI LONDON
PA THIRD FLOOR, EAGLE HOUSE, 16 PROCTER STREET, LONDON WC1V 6 NX, ENGLAND
SN 0300-5127
J9 BIOCHEM SOC T
JI Biochem. Soc. Trans.
PD APR
PY 2010
VL 38
BP 498
EP 506
DI 10.1042/BST0380498
PN 2
PG 9
WC Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA 585DR
UT WOS:000276805000036
PM 20298210
ER
PT J
AU Ploeger, A
Raijmakers, MEJ
van der Maas, HLJ
Galis, F
AF Ploeger, Annemie
Raijmakers, Maartje E. J.
van der Maas, Han L. J.
Galis, Frietson
TI The Association Between Autism and Errors in Early Embryogenesis: What
Is the Causal Mechanism?
SO BIOLOGICAL PSYCHIATRY
LA English
DT Review
DE Autism; critical periods; early organogenesis; medical comorbidities;
physical anomalies; prenatal complications
ID EMBRYONIC PERIOD PROPER; OF-THE-LITERATURE; CONGENITAL-RUBELLA;
NEUROFIBROMATOSIS TYPE-1; TUBEROUS SCLEROSIS; SPECTRUM DISORDERS;
MATERNAL RUBELLA; DOWNS-SYNDROME; SEQUENCE; EVENTS
AB The association between embryonic errors and the development of autism has been recognized in the literature, but the mechanism underlying this association remains unknown. We propose that pleiotropic effects during a very early and specific stage of embryonic development early organogenesis can explain this association. In humans early organogenesis is an embryonic stage, spanning Day 20 to Day 40 after fertilization, which is characterized by intense interactivity among body parts of the embryo. This implies that a single mutation or environmental disturbance affecting development at this stage can have several phenotypic effects (i.e., pleiotropic effects). Disturbances during early organogenesis can lead to many different anomalies, including limb deformities, craniofacial malformations, brain pathology, and anomalies in other organs. We reviewed the literature and found ample evidence for the association between autism and different kinds of physical anomalies, which agrees with the hypothesis that pleiotropic effects are involved in the development of autism. The proposed mechanism integrates findings from a variety of studies on autism, including neurobiological studies and studies on physical anomalies and prenatal influences on neurodevelopmental outcomes. The implication is that the origin of autism can be much earlier in embryologic development than has been frequently reported.
C1 [Ploeger, Annemie; Raijmakers, Maartje E. J.; van der Maas, Han L. J.] Univ Amsterdam, Dept Psychol, NL-1018 WB Amsterdam, Netherlands.
[Galis, Frietson] Leiden Univ, Dept Biol, Leiden, Netherlands.
RP Ploeger, A (reprint author), Univ Amsterdam, Dept Psychol, Roetersstr 15, NL-1018 WB Amsterdam, Netherlands.
EM a.ploeger@uva.nl
FU Netherlands Organisation for Scientific Research (NWO)
FX We would like to thank Conor Dolan, Catharina Hartman, Chantel Kemner,
Claus Rueffler, and Andrew Shaner for their continents on earlier drafts
of the manuscript. Dr. Ploeger reports having received research funding
from the Evolution and Behavior program of the Netherlands Organisation
for Scientific Research (NWO). Drs. Raijmakers, Van der Maas, and Galls
reported no biomedical financial interests or potential conflicts of
interest.
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NR 84
TC 17
Z9 17
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD APR 1
PY 2010
VL 67
IS 7
BP 602
EP 607
DI 10.1016/j.biopsych.2009.10.010
PG 6
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA 574QY
UT WOS:000276008700002
PM 19932467
ER
PT J
AU Lonetti, G
Angelucci, A
Morando, L
Boggio, EM
Giustetto, M
Pizzorusso, T
AF Lonetti, Giuseppina
Angelucci, Andrea
Morando, Laura
Boggio, Elena M.
Giustetto, Maurizio
Pizzorusso, Tommaso
TI Early Environmental Enrichment Moderates the Behavioral and Synaptic
Phenotype of MeCP2 Null Mice
SO BIOLOGICAL PSYCHIATRY
LA English
DT Article
DE Anxiety; BDNF; environmental enrichment; learning; memory; LTP; Rett
syndrome
ID VISUAL-SYSTEM DEVELOPMENT; CPG-BINDING PROTEIN-2; RETT-SYNDROME; MOUSE
MODEL; MATERNAL-CARE; MUTANT MICE; TRANSCRIPTIONAL REPRESSOR; BDNF
TRANSCRIPTION; PLASTICITY; EXPRESSION
AB Background: Rett syndrome (RTT) is an X-linked progressive neurodevelopmental disorder characterized by a variety of symptoms including motor abnormalities, mental retardation, anxiety, and autism. Most of RTT cases are caused by mutations of MeCP2. In mice, impaired MeCP2 function results in synaptic deficits associated with motor, cognitive, and emotional alterations. Environmental enrichment (EE) is a rearing condition that enhances synapse formation and plasticity. Previous studies analyzing the effects of postweaning EE found limited effects on motor performance of male MeCP2 mutants. However, EE during early postnatal development produces powerful effects on neural development and plasticity. Thus, we tested whether early EE could ameliorate several phenotypes of male homozygous and female heterozygous MeCP2 mutants.
Methods: We investigated the effects of early EE on motor coordination, structural and functional synaptic plasticity, and brain-derived neurotrophic factor expression in male MeCP2 null mice. Anxiety-related behavior and spatial learning was analyzed in heterozygous MeCP2 female mice.
Results: In male mutants, EE modified excitatory and to a lesser extent inhibitory synaptic density in cerebellum and cortex, reversed the cortical long-term potentiation deficit and augmented cortical brain-derived neurotrophic factor levels. Environmental enrichment also ameliorated motor coordination and motor learning. In female heterozygous mice, a model closely mimicking some aspects of RTT symptoms, EE rescued memory deficits in the Morris water maze and decreased anxiety-related behavior.
Conclusions: Early EE dramatically improves several phenotypes of MeCP2 mutants. Thus, environmental factors should be taken into account when analyzing phenotypes of MeCP2 knockout mice, an accepted model of RTT. Early EE might be beneficial in RTT patients.
C1 [Pizzorusso, Tommaso] CNR, Neurosci Inst Pisa, Area Ric, I-56100 Pisa, Italy.
[Pizzorusso, Tommaso] Univ Florence, Dip Psicol, Florence, Italy.
[Morando, Laura; Boggio, Elena M.; Giustetto, Maurizio] Univ Turin, Dip Anat, Turin, Italy.
Natl Inst Neurosci Italy, Turin, Italy.
RP Pizzorusso, T (reprint author), CNR, Neurosci Inst Pisa, Area Ric, Via Moruzzi 1, I-56100 Pisa, Italy.
EM pizzorusso@in.cnr.it
RI giustetto, maurizio/D-6606-2011
OI giustetto, maurizio/0000-0003-1323-4060
FU Telethon [GGP05236, GGP09196]; Regione Piemonte [142]; European Union
[STRP 033378]; EuroRETT
FX This work was supported by the Telethon Grants GGP05236 and GGP09196 (to
TP and MG), Regione Piemonte (n. 142 to MIUR-PRIN (to MG and TP) and the
Non Invasive Nanotransducer for In Vivo gene thErapy (STRP 033378) FP6
European Union project to TP. We thank Dr. Federica Cirimbilli for help
behavioral experiments. We thank Professor E. Castren and Dr. T.
Rantamaki the kind gift of BDNF KO tissue samples. We thank the EuroRETT
project for financial support.
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NR 52
TC 60
Z9 62
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD APR 1
PY 2010
VL 67
IS 7
BP 657
EP 665
DI 10.1016/j.biopsych.2009.12.022
PG 9
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA 574QY
UT WOS:000276008700009
PM 20172507
ER
PT J
AU Vattikuti, S
Chow, CC
AF Vattikuti, Shashaank
Chow, Carson C.
TI A Computational Model for Cerebral Cortical Dysfunction in Autism
Spectrum Disorders
SO BIOLOGICAL PSYCHIATRY
LA English
DT Article
DE Cognitive shifting; cortical circuit; fragile X syndrome; minicolumn;
saccade; synaptic balance
ID LATERAL INTRAPARIETAL AREA; FRAGILE-X-SYNDROME; GABAERGIC INHIBITION;
DOWN-REGULATION; NETWORK MODEL; MOUSE MODEL; OCULOMOTOR; ABNORMALITIES;
CATATONIA; DEFICITS
AB Background: Perturbations to the microscopic level balance between synaptic excitation and inhibition and neuron organization in the cerebral cortex are suggested to underlie autism spectrum disorder (ASD) traits. The mechanism linking these perturbations to cognitive behaviors in ASD is unknown. This study strives to bridge this gap by generating clinically testable diagnostic and pharmacological predictions based on the effect of synaptic imbalance and neuron distribution on a computational local circuit model of the cerebral cortex.
Methods: We use a computational microscopic model of the cerebral cortex that incorporates N-methyl-D-aspartate and gamma-aminobutyric acid synaptic kinetics. We employ the model circuit during model tasks similar to visually guided and gap oculomotor saccade tasks and interpret qualitative model predictions of saccade hypometria and dysmetria. We consider the effects of varying the excitatory to inhibitory synaptic balance, neuron density, and neuron clustering in this model.
Results: An increase of synaptic excitation over synaptic inhibition results in increased hypometria and dysmetria. Similar effects by either reduced inhibition or increased excitation suggest that a variety of pharmacological compounds can be used for both screening and medical management. On the other hand, any change to the microscopic neuron anatomy that increases the effective maximum distance between excitatory neurons decreases hypometria but has no affect on dysmetria.
Conclusions: Perturbations to a computational model of a local cerebral cortical circuit can account for saccade hypometria and dysmetria reported in ASD studies. This approach may provide a direct link between cerebral cortical function and ASD behaviors.
C1 [Vattikuti, Shashaank; Chow, Carson C.] NIDDK, Lab Biol Modeling, NIH, Bethesda, MD 20892 USA.
RP Chow, CC (reprint author), NIDDK, Lab Biol Modeling, NIH, Bldg 12A,Room 4007, Bethesda, MD 20892 USA.
EM carsonc@mail.nih.gov
RI Chow, Carson/A-7970-2009
FU National Institutes of Health/National Institute of Diabetes and
Digestive and kidney Diseases
FX This work was supported by the Intramural Research Program of the
National Institutes of Health/National Institute of Diabetes and
Digestive and kidney Diseases.
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NR 45
TC 19
Z9 19
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD APR 1
PY 2010
VL 67
IS 7
BP 672
EP 678
DI 10.1016/j.biopsych.2009.09.008
PG 7
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA 574QY
UT WOS:000276008700011
PM 19880095
ER
PT J
AU Kawikova, I
Grady, BPX
Tobiasova, Z
Zhang, Y
Vojdani, A
Katsovich, L
Richmand, BJ
Park, TW
Bothwell, ALM
Leckman, JF
AF Kawikova, Ivana
Grady, Bart P. X.
Tobiasova, Zuzana
Zhang, Yan
Vojdani, Aristo
Katsovich, Liliya
Richmand, Brian J.
Park, Tae Won
Bothwell, Alfred L. M.
Leckman, James F.
TI Children with Tourette's Syndrome May Suffer Immunoglobulin A
Dysgammaglobulinemia: Preliminary Report
SO BIOLOGICAL PSYCHIATRY
LA English
DT Article
DE Autoimmunity; immune deficiency; immunoglobulins; Group A beta-hemolytic
streptococcus; PANDAS; Tourette's syndrome
ID NECROSIS-FACTOR-ALPHA; STREPTOCOCCAL INFECTION; MOVEMENT-DISORDERS; TIC
DISORDER; T-CELLS; LYMPHOCYTES; PNEUMONIAE; ANTIBODIES; AUTISM; BLOOD
AB Background: Postinfectious autoimmunity has been implicated in burette's syndrome and obsessive-compulsive disorder (TS/OCD), whereas increased frequency of upper respiratory tract infections (URTI) in TS/OCD patients suggests immune deficiency. We hypothesized that antineuronal antibodies may be elevated in patients (reflecting autoimmune processes), and levels of total immunoglobulins (Igs) may be decreased (reflecting immune deficiency).
Methods: We analyzed plasma of TS/OCD patients (n = 24) and healthy age- and sex-matched control subjects (n = 22) by enzyme-linked immunosorbent assay (ELISA) for the levels of total and specific IgG, IgM, and IgA against antigens previously identified in multiple sclerosis (myelin basic protein and myelin-associated glycoprotein) and Sydenham's chorea (ganglioside-GM1, lysoganglioside, and tubulin).
Results: Total IgA was decreased in TS/OCD patients (median 115 mg/100 mL) compared with control subjects (141 mg/100 mL; p = .02). Specific IgA against all antigens, except tubulin were also decreased in the patients (MPB 0 vs. 13 [ELISA units [EU]; myelin-associated glycoprotein 29 vs. 44 EU, p = .04; ganglioside GM1 21 vs. 35 EU, p = .01; lysoganglioside 44 vs. 56 EU, p = .03; tubulin 44 vs. 44 EU, p = .8). The levels of total IgA and anti-myelin basic protein (MBP) IgA were significantly lower in the subgroup of pediatric autoimmune neuropsychiatric disorder associated with Streptococcus (PANDAS) cases (n = 10) than in non-PANDAS cases (n = 9; total IgA 98 mg/100 mL vs. 133 mg/mL, p = .03; anti-MBP IgA 1 vs. 6 EU, p = .03) or healthy control subjects (total IgA 141 mg/100 mL, p = .02; anti-MBP IgA 13 EU, p = .005).
Conclusions: At least some TS/OCD patients may suffer IgA dysgammaglobulinemia, possibly rendering the children more prone to URTI.
C1 [Kawikova, Ivana; Grady, Bart P. X.; Tobiasova, Zuzana; Zhang, Yan; Bothwell, Alfred L. M.] Yale Univ, Sch Med, Dept Immunobiol, New Haven, CT 06520 USA.
[Katsovich, Liliya; Richmand, Brian J.; Park, Tae Won; Leckman, James F.] Yale Univ, Sch Med, Ctr Child Study, New Haven, CT 06520 USA.
[Vojdani, Aristo] Immunosci Lab Inc, Beverly Hills, CA USA.
RP Kawikova, I (reprint author), Yale Univ, Sch Med, Dept Immunobiol, 630 TAC,300 Cedar St, New Haven, CT 06520 USA.
EM ivana.kawikova@yale.edu
RI Grady, Bart/F-3410-2013
FU Tourette's Syndrome Association; National Institutes of Health; Echlin
Foundation
FX The study was supported by a Tourette's Syndrome Association Research
Grant (IK), National Institutes of Health grants (JFL), and additional
funds to Dr. Leckman from Brian and Linda Richmond (B. Richmand is one
of the coauthors), Betsey Henley-Cohn, Scott D, and Amy I. Horwitz,
Marty and Susan Kravet, Samuel Gejdenson, and the Echlin Foundation. We
thank Mrs. Heidi Grantz for coordination of the clinical studies.
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NR 27
TC 17
Z9 18
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD APR 1
PY 2010
VL 67
IS 7
BP 679
EP 683
DI 10.1016/j.biopsych.2009.09.034
PG 5
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA 574QY
UT WOS:000276008700012
PM 20006327
ER
PT J
AU Guastella, AJ
Einfeld, SL
Gray, KM
Rinehart, NJ
Tonge, BJ
Lambert, TJ
Hickie, IB
AF Guastella, Adam J.
Einfeld, Stewart L.
Gray, Kylie M.
Rinehart, Nicole J.
Tonge, Bruce J.
Lambert, Timothy J.
Hickie, Ian B.
TI Intranasal Oxytocin Improves Emotion Recognition for Youth with Autism
Spectrum Disorders
SO BIOLOGICAL PSYCHIATRY
LA English
DT Article
DE Autism; developmental disorders; emotion; emotion recognition; face;
oxytocin; social cognition
ID DEVELOPMENTAL BEHAVIOR CHECKLIST; COMMUNICATION; HUMANS; ADULTS; FACES;
MIND
AB Background: A diagnostic hallmark of autism spectrum disorders is a qualitative impairment in social communication and interaction. Deficits in the ability to recognize the emotions of others are believed to contribute to this. There is currently no effective treatment for these problems.
Methods: In a double-blind, randomized, placebo-controlled, crossover design, we administered oxytocin nasal spray (18 or 24 IU) or a placebo to 16 male youth aged 12 to 19 who were diagnosed with Autistic or Asperger's Disorder. Participants then completed the Reading the Mind in the Eyes Task, a widely used and reliable test of emotion recognition.
Results: In comparison with placebo, oxytocin administration improved performance on the Reading the Mind in the Eyes Task. This effect was also shown when analysis was restricted to the younger participants aged 12 to 15 who received the lower dose.
Conclusions: This study provides the first evidence that oxytocin nasal spray improves emotion recognition in young people diagnosed with autism spectrum disorders. Findings suggest the potential of earlier intervention and further evaluation of oxytocin nasal spray as a treatment to improve social communication and interaction in young people with autism spectrum disorders.
C1 [Guastella, Adam J.; Einfeld, Stewart L.; Lambert, Timothy J.; Hickie, Ian B.] Univ Sydney, Brain & Mind Res Inst, Sydney, NSW 2050, Australia.
[Einfeld, Stewart L.] Univ Sydney, Fac Hlth Sci, Sydney, NSW 2050, Australia.
[Gray, Kylie M.; Rinehart, Nicole J.; Tonge, Bruce J.] Monash Univ, Ctr Dev Psychiat & Psychol, Sch Psychol Psychiat & Psychol Med, Melbourne, Vic 3004, Australia.
RP Guastella, AJ (reprint author), Univ Sydney, Brain & Mind Res Inst, Sydney, NSW 2050, Australia.
EM aguastella@med.usyd.edu.au
RI Gray, Kylie/H-3345-2014
OI Gray, Kylie/0000-0001-6518-4240
FU Brain & Mind Research Institute; National Health and Medical Research
Council [570897]
FX This study was funded by both the Brain & Mind Research Institute and
National Health and Medical Research Council Project Grant Number
570897.
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NR 19
TC 250
Z9 256
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD APR 1
PY 2010
VL 67
IS 7
BP 692
EP 694
DI 10.1016/j.biopsych.2009.09.020
PG 3
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA 574QY
UT WOS:000276008700014
PM 19897177
ER
PT J
AU Keen, DV
Reid, FD
Arnone, D
AF Keen, D. V.
Reid, F. D.
Arnone, D.
TI Autism, ethnicity and maternal immigration
SO BRITISH JOURNAL OF PSYCHIATRY
LA English
DT Article
ID PERVASIVE DEVELOPMENTAL DISORDERS; PERINATAL RISK-FACTORS; SPECTRUM
DISORDERS; PATERNAL AGE; DIAGNOSTIC INTERVIEW; INFANTILE-AUTISM;
CHILDREN BORN; POPULATION; PREVALENCE; CALIFORNIA
AB Background
A growing number of European studies, particularly from Nordic countries, suggest an increased frequency of autism in children of immigrant parents. In contrast, North American studies tend to conclude that neither maternal ethnicity nor immigrant status are related to the rate of autism-spectrum disorders.
Aims
To examine the hypotheses that maternal ethnicity and/or immigration are linked to the rate of childhood autism-spectrum disorders.
Method
Retrospective case-note analysis of all 428 children diagnosed with autism-spectrum disorders presenting to the child development services in two centres during a 6-year period.
Results
Mothers born outside Europe had a significantly higher risk of having a child with an autism-spectrum disorder compared with those born in the UK, with the highest risk observed for the Caribbean group (relative risks (RRs) in the two centres: RR = 10.01, 95% CI 5.53-18.1 and RR = 8.89, 95% CI 5.08-15.5). Mothers of Black ethnicity had a significantly higher risk compared with White mothers (RR = 8.28, 95% CI 5.41-12.7 and RR = 3.84, 95% CI 2.93-5.02). Analysis of ethnicity and immigration factors together suggests the increased risk is predominately related to immigration.
Conclusions
Maternal immigration is associated with substantial increased risk of autism-spectrum disorders with differential risk according to different region of birth and possibly ethnicity.
C1 [Keen, D. V.] St Georges Healthcare NHS Trust, London, England.
[Reid, F. D.] Univ London, London WC1E 7HU, England.
[Arnone, D.] Univ Manchester, Neurosci & Psychiat Unit, Oxford, England.
[Arnone, D.] Warneford Hosp, Univ Dept Psychiat, Oxford OX3 7JX, England.
RP Keen, DV (reprint author), St George Hosp, Room 2-35,2nd Floor Clare House,Blackshaw Rd, London SW17 0QT, England.
EM daphne.keen@stgeorges.nhs.uk
RI Arnone, Danilo/A-3974-2012
FU Medical Research Council UK
FX D.A. is currently supported by the Medical Research Council UK.
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NR 42
TC 28
Z9 28
PU ROYAL COLLEGE OF PSYCHIATRISTS
PI LONDON
PA BRITISH JOURNAL OF PSYCHIATRY 17 BELGRAVE SQUARE, LONDON SW1X 8PG,
ENGLAND
SN 0007-1250
J9 BRIT J PSYCHIAT
JI Br. J. Psychiatry
PD APR
PY 2010
VL 196
IS 4
BP 274
EP 281
DI 10.1192/bjp.bp.109.065490
PG 8
WC Psychiatry
SC Psychiatry
GA 578JF
UT WOS:000276288900006
PM 20357302
ER
PT J
AU Donno, R
Parker, G
Gilmour, J
Skuse, DH
AF Donno, R.
Parker, G.
Gilmour, J.
Skuse, D. H.
TI Social communication deficits in disruptive primary-school children
SO BRITISH JOURNAL OF PSYCHIATRY
LA English
DT Article
ID AUTISTIC SPECTRUM DISORDERS; DIAGNOSTIC INTERVIEW; ASPERGER-SYNDROME;
REVISED VERSION; MIND; ASSOCIATIONS; RECOGNITION; POPULATION;
PREVALENCE; INTERESTS
AB Background
Parent and teacher data, from questionnaire surveys, suggest that school-identified disruptive children often have pragmatic language deficits of an autistic type.
Aims
This replication study aimed to confirm earlier findings, using individual clinical assessment to investigate traits of autism-spectrum disorder in disruptive children.
Method
Persistently disruptive children (n = 26) and a comparison group (n = 22) were recruited from primary schools in a deprived inner-city area. Measures included standardised autism diagnostic interviews (with parents) and tests of IQ, social cognition, theory of mind and attention (with children).
Results
The disruptive children possessed poorer pragmatic language skills (P<0.0001) and mentalising abilities (P<0.05) than comparisons. Nine disruptive children (35%) met ICD-10 criteria for atypical autism or Asperger syndrome.
Conclusions
Many persistently disruptive children have undetected disorders of social communication, which are of potential aetiological significance.
C1 [Skuse, D. H.] UCL, Inst Child Hlth, Behav & Brain Sci Unit, London WC1N 1EH, England.
[Donno, R.] Great Ormond St Hosp Sick Children, Psychosocial & Family Serv, London WC1N 3JH, England.
[Parker, G.] Mile End Hosp, Rehabil & Hlth Psychol Serv, London, England.
[Gilmour, J.] UCL, Subdept Clin Hlth Psychol, London WC1N 1EH, England.
RP Skuse, DH (reprint author), UCL, Inst Child Hlth, Behav & Brain Sci Unit, London WC1N 1EH, England.
EM dskuse@ich.ucl.ac.uk
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
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World Health Organisation, 1996, ICD 10 CLASS MENT BE
NR 40
TC 21
Z9 21
PU ROYAL COLLEGE OF PSYCHIATRISTS
PI LONDON
PA BRITISH JOURNAL OF PSYCHIATRY 17 BELGRAVE SQUARE, LONDON SW1X 8PG,
ENGLAND
SN 0007-1250
J9 BRIT J PSYCHIAT
JI Br. J. Psychiatry
PD APR
PY 2010
VL 196
IS 4
BP 282
EP 289
DI 10.1192/bjp.bp.108.061341
PG 8
WC Psychiatry
SC Psychiatry
GA 578JF
UT WOS:000276288900007
PM 20357304
ER
PT J
AU Johansson, CF
AF Johansson, Carl Fredrik
TI The Imprinted Brain: How Genes Set the Balance between Autism and
Psychosis
SO BRITISH JOURNAL OF PSYCHIATRY
LA English
DT Book Review
C1 [Johansson, Carl Fredrik] S Kensington & Chelsea NHS Fdn Trust, London, England.
RP Johansson, CF (reprint author), S Kensington & Chelsea NHS Fdn Trust, London, England.
EM freddie.johansson@nhs.net
CR BADCOCK C, 2009, IMPRINTED BRAIN HOW
NR 1
TC 0
Z9 0
PU ROYAL COLLEGE OF PSYCHIATRISTS
PI LONDON
PA BRITISH JOURNAL OF PSYCHIATRY 17 BELGRAVE SQUARE, LONDON SW1X 8PG,
ENGLAND
SN 0007-1250
J9 BRIT J PSYCHIAT
JI Br. J. Psychiatry
PD APR
PY 2010
VL 196
IS 4
BP 334
EP 335
DI 10.1192/bjp.bp.109.071084
PG 2
WC Psychiatry
SC Psychiatry
GA 578JF
UT WOS:000276288900024
ER
PT J
AU Begue, P
AF Begue, Pierre
TI Consequences of opposition to vaccination in France and Europe. How to
maintain effective vaccine coverage in 2010?
SO BULLETIN DE L ACADEMIE NATIONALE DE MEDECINE
LA French
DT Article
DE VACCINATION; MASS VACCINATION; TREATMENT REFUSAL
ID MMR VACCINATION; IMMUNIZATION; MEASLES; RUBELLA; MUMPS; PERTUSSIS;
DISEASES; PARENTS; REFUSAL; AUTISM
AB Refusal of vaccination can result in inadequate vaccine coverage. The collective benefit of immunisation depends on a sufficient and sustained level of vaccine coverage. Low vaccine coverage can lead to the persistence of preventable diseases and, in some cases, to a dangerous shift in the age of pathogen encounter towards adulthood. This is the case of measles in Europe, where some countries, including France, have not reached the effective vaccine coverage rate of 95 %. Outbreaks are occurring, leading to complications (encephalitis and pneumonia) in adolescents and adults, necessitating hospitalization in nearly one-third of cases. The French population is also under-vaccinated against hepatitis B, due to fears of a risk of demyelinating disorders: the coverage rate is currently only about 30 % in infants and 10 % in adolescents. These difficulties are due to negligence and to vaccine refusal by parents. Refusal of immunisation has a long history in Europe, and explains for example why pertussis remained endemic in many countries until 1995, and also the resurgence of diphtheria in the Russian federation during the 1990s. Sections of Western society are now questioning the need for some routine vaccines, overlooking the fact that they have eradicated some diseases (polio, diphtheria, etc.) and protect effectively against lesser-known pathogens such as hepatitis B virus and HP V. In France, it will be necessary to restructure healthcare professional training programs in vaccinology and to provide the public with more thorough information on the risk-benefit ratio of vaccination. The recent controversy surrounding pandemic H1N1 influenza vaccination demonstrates that the public and the media tend to focus more on the potential risks of vaccination than on its benefits. A vigorous ethical and political debate is needed to shape an effective and acceptable vaccine policy for the 21(st) century.
EM pbegue@wanadoo.fr
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*WHO REG OFF EUR, DIPHTH CONTR DIPHTH
NR 26
TC 4
Z9 4
PU ACAD NATL MEDECINE
PI PARIS 06
PA 16 RUE BONAPARTE, 75272 PARIS 06, FRANCE
SN 0001-4079
J9 B ACAD NAT MED PARIS
JI Bull. Acad. Natl. Med.
PD APR-MAY
PY 2010
VL 194
IS 4-5
BP 719
EP 732
PG 14
WC Medicine, General & Internal
SC General & Internal Medicine
GA 683YO
UT WOS:000284514400004
PM 21568045
ER
PT J
AU Santha, JC
AF Santha, Josiane Caron
TI Group work for Children with Autism Spectrum Disorder, Ages 5-11, An
Integrated Approach
SO CANADIAN JOURNAL OF OCCUPATIONAL THERAPY-REVUE CANADIENNE D ERGOTHERAPIE
LA English
DT Book Review
CR HOWE C, 2008, GROUP WORK CHILDREN
NR 1
TC 0
Z9 0
PU CANADIAN ASSOC OCCUPATIONAL THERAPISTS
PI OTTAWA
PA CTTC BLDG, 3400-1125 COLONEL BY DRIVE, OTTAWA, ONTARIO K1S 5R1, CANADA
SN 0008-4174
J9 CAN J OCCUP THER
JI Can. J. Occup. Ther.
PD APR
PY 2010
VL 77
IS 2
BP 100
EP 100
PG 1
WC Rehabilitation
SC Rehabilitation
GA V20TP
UT WOS:000208162600007
ER
PT J
AU Santha, JC
AF Santha, Josiane Caron
TI Group work for Children with Autism Spectrum Disorder, Ages 3-5, An
Integrated Approach
SO CANADIAN JOURNAL OF OCCUPATIONAL THERAPY-REVUE CANADIENNE D ERGOTHERAPIE
LA English
DT Book Review
CR DAVIDSON LA, 2007, GROUP WORK CHILDREN
NR 1
TC 0
Z9 0
PU CANADIAN ASSOC OCCUPATIONAL THERAPISTS
PI OTTAWA
PA CTTC BLDG, 3400-1125 COLONEL BY DRIVE, OTTAWA, ONTARIO K1S 5R1, CANADA
SN 0008-4174
J9 CAN J OCCUP THER
JI Can. J. Occup. Ther.
PD APR
PY 2010
VL 77
IS 2
BP 100
EP 100
PG 1
WC Rehabilitation
SC Rehabilitation
GA V20TP
UT WOS:000208162600008
ER
PT J
AU Surridge, MS
AF Surridge, M. Sian
TI STOP That Seemingly Senseless Behaviour! FBA-Based Interventions for
People with Autism
SO CANADIAN JOURNAL OF OCCUPATIONAL THERAPY-REVUE CANADIENNE D ERGOTHERAPIE
LA English
DT Book Review
CR Glasberg BA, 2008, STOP SEEMINGLY SENSE
NR 1
TC 0
Z9 0
PU CANADIAN ASSOC OCCUPATIONAL THERAPISTS
PI OTTAWA
PA CTTC BLDG, 3400-1125 COLONEL BY DRIVE, OTTAWA, ONTARIO K1S 5R1, CANADA
SN 0008-4174
J9 CAN J OCCUP THER
JI Can. J. Occup. Ther.
PD APR
PY 2010
VL 77
IS 2
BP 112A
EP 112A
PG 1
WC Rehabilitation
SC Rehabilitation
GA V20TP
UT WOS:000208162600010
ER
PT J
AU Leew, SV
Stein, NG
Ben Gibbard, W
AF Leew, Shirley V.
Stein, Nicole G.
Ben Gibbard, W.
TI Weighted vests' effect on social attention for toddlers with Autism
Spectrum Disorders
SO CANADIAN JOURNAL OF OCCUPATIONAL THERAPY-REVUE CANADIENNE D ERGOTHERAPIE
LA English
DT Article
DE Autistic disorder; Infancy and childhood; Sensory motor integration;
Weighted vests
AB Background. There is limited research validating the use of weighted vests for problem behaviours/social attention in toddlers with autism spectrum disorders (ASD) although vests are commonly used in early intervention to improve attention. Purpose. The effect of weighted vests on competing behaviours and joint attention (a pivotal skill for development and a core deficit for toddlers with ASD) in semi-structured play with their mothers was investigated. Methods. A multiple baseline design that included generalization probes to provide evidence of treatment effects across adult female play partners. Unambiguous definitions were created for competing behaviours and joint attention resulting in good inter-observer reliability. Mothers' morale was measured pre- and post-intervention. Findings. There were no replicated effects of vests on competing behaviours or joint attention. Mothers experienced increased morale in spite of null effects of the intervention. Implications. The findings suggest needed re-evaluation of the use of weighted vests with toddlers.
C1 [Leew, Shirley V.; Stein, Nicole G.] Univ Alberta, Alberta Hlth Serv, Child Dev Ctr, Calgary, AB T3B 6A8, Canada.
[Leew, Shirley V.] Univ Alberta, Alberta Childrens Hosp, Calgary, AB T3B 6A8, Canada.
RP Leew, SV (reprint author), Univ Alberta, Alberta Hlth Serv, Child Dev Ctr, Rm C4-316,2888 Shaganappi Tr NW, Calgary, AB T3B 6A8, Canada.
EM Shirley.leew@albertahealthservices.ca
FU Alberta Centre for Child, Family, and Community Research [E-20119];
Allied Health Research Award; Alberta Children's Hospital Foundation;
Decision Support Research Team, Alberta Children's Hospital
FX Alberta Centre for Child, Family, and Community Research (E-20119);
Allied Health Research Award, Alberta Children's Hospital Foundation;
and research support from the Decision Support Research Team, Alberta
Children's Hospital.
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NR 19
TC 8
Z9 8
PU CANADIAN ASSOC OCCUPATIONAL THERAPISTS
PI OTTAWA
PA CTTC BLDG, 3400-1125 COLONEL BY DRIVE, OTTAWA, ONTARIO K1S 5R1, CANADA
SN 0008-4174
J9 CAN J OCCUP THER
JI Can. J. Occup. Ther.
PD APR
PY 2010
VL 77
IS 2
BP 113
EP 123
DI 10.2182/cjot.2010.77.2.7
PG 11
WC Rehabilitation
SC Rehabilitation
GA V20TP
UT WOS:000208162600011
PM 20464896
ER
PT J
AU Asher, A
AF Asher, Asha
TI Seeing is Believing: Video Self-Modeling For People With Autism and
Developmental Disabilities
SO CANADIAN JOURNAL OF OCCUPATIONAL THERAPY-REVUE CANADIENNE D ERGOTHERAPIE
LA English
DT Book Review
CR BUGGEY T, 2009, SEEING BELIEVING VID
NR 1
TC 0
Z9 0
PU CANADIAN ASSOC OCCUPATIONAL THERAPISTS
PI OTTAWA
PA CTTC BLDG, 3400-1125 COLONEL BY DRIVE, OTTAWA, ONTARIO K1S 5R1, CANADA
SN 0008-4174
J9 CAN J OCCUP THER
JI Can. J. Occup. Ther.
PD APR
PY 2010
VL 77
IS 2
BP 125
EP 125
PG 1
WC Rehabilitation
SC Rehabilitation
GA V20TP
UT WOS:000208162600013
ER
PT J
AU Minami, T
Miyata, E
Sakamoto, Y
Yamazaki, H
Ichida, S
AF Minami, Takeshi
Miyata, Eriko
Sakamoto, Yamato
Yamazaki, Hideo
Ichida, Seiji
TI Induction of metallothionein in mouse cerebellum and cerebrum with
low-dose thimerosal injection
SO CELL BIOLOGY AND TOXICOLOGY
LA English
DT Article
DE Thimerosal; Ethyl mercury; Metallothionein; Cerebellum; Cerebrum;
Capillary zone electrophoresis
ID NEURODEVELOPMENTAL DISORDERS; MERCURY CONCENTRATIONS; ASTROCYTE
CULTURES; RAT-BRAIN; METHYLMERCURY; AUTISM; EXPRESSION; VACCINES;
LOCALIZATION; ETHYLMERCURY
AB Thimerosal, an ethyl mercury compound, is used worldwide as a vaccine preservative. We previously observed that the mercury concentration in mouse brains did not increase with the clinical dose of thimerosal injection, but the concentration increased in the brain after the injection of thimerosal with lipopolysaccharide, even if a low dose of thimerosal was administered. Thimerosal may penetrate the brain, but is undetectable when a clinical dose of thimerosal is injected; therefore, the induction of metallothionein (MT) messenger RNA (mRNA) and protein was observed in the cerebellum and cerebrum of mice after thimerosal injection, as MT is an inducible protein. MT-1 mRNA was expressed at 6 and 9 h in both the cerebrum and cerebellum, but MT-1 mRNA expression in the cerebellum was three times higher than that in the cerebrum after the injection of 12 A mu g/kg thimerosal. MT-2 mRNA was not expressed until 24 h in both organs. MT-3 mRNA was expressed in the cerebellum from 6 to 15 h after the injection, but not in the cerebrum until 24 h. MT-1 and MT-3 mRNAs were expressed in the cerebellum in a dose-dependent manner. Furthermore, MT-1 protein was detected from 6 to 72 h in the cerebellum after 12 A mu g/kg of thimerosal was injected and peaked at 10 h. MT-2 was detected in the cerebellum only at 10 h. In the cerebrum, little MT-1 protein was detected at 10 and 24 h, and there were no peaks of MT-2 protein in the cerebrum. In conclusion, MT-1 and MT-3 mRNAs but not MT-2 mRNA are easily expressed in the cerebellum rather than in the cerebrum by the injection of low-dose thimerosal. It is thought that the cerebellum is a sensitive organ against thimerosal. As a result of the present findings, in combination with the brain pathology observed in patients diagnosed with autism, the present study helps to support the possible biological plausibility for how low-dose exposure to mercury from thimerosal-containing vaccines may be associated with autism.
C1 [Minami, Takeshi; Miyata, Eriko; Yamazaki, Hideo] Kinki Univ, Dept Life Sci, Sch Sci & Engn, Osaka 5778502, Japan.
[Sakamoto, Yamato; Ichida, Seiji] Kinki Univ, Dept Clin Pharm, Sch Pharmaceut Sci, Osaka 5778502, Japan.
RP Minami, T (reprint author), Kinki Univ, Dept Life Sci, Sch Sci & Engn, 3-4-1 Kowakae, Osaka 5778502, Japan.
EM minamita@life.kindai.ac.jp
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NR 64
TC 12
Z9 13
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0742-2091
EI 1573-6822
J9 CELL BIOL TOXICOL
JI Cell Biol. Toxicol.
PD APR
PY 2010
VL 26
IS 2
BP 143
EP 152
DI 10.1007/s10565-009-9124-z
PG 10
WC Cell Biology; Toxicology
SC Cell Biology; Toxicology
GA 562XU
UT WOS:000275090000006
PM 19357975
ER
PT J
AU Crepel, A
Breckpot, J
Fryns, JP
De la Marche, W
Steyaert, J
Devriendt, K
Peeters, H
AF Crepel, A.
Breckpot, J.
Fryns, J-P
De la Marche, W.
Steyaert, J.
Devriendt, K.
Peeters, H.
TI DISC1 duplication in two brothers with autism and mild mental
retardation
SO CLINICAL GENETICS
LA English
DT Article
DE 1q42; 2; autism; DISC1; duplication
ID COPY-NUMBER VARIATION; SPECTRUM DISORDER; HUMAN GENOME; SCHIZOPHRENIA;
ASSOCIATION; POPULATION; FAMILY; GENES; SCALE; TRANSLOCATION
AB We describe the identification and delineation of an inherited 2.07 Mb microduplication in 1q42.2 in two brothers with autism and mild mental retardation. Since this duplication was not present in 1577 Belgian persons, we consider this as an extremely rare variant which has the potential to provide further insight into the genetics of autism. The duplication contains seven genes including the DISC1 gene, an interesting candidate gene that has been associated to schizophrenia, bipolar disorder, autism and Asperger syndrome. In this report we describe additional analyses undertaken to investigate the causal relationship of the duplication to the autism phenotype. We conclude that the 1q42.2 microduplication probably confers susceptibility to autism in the current family. This study is a typical illustration of the difficult interpretation of causality of a very rare variant in neuropsychiatric disease and the challenge of genetic counselling in a particular family.
C1 [Crepel, A.; Breckpot, J.; Fryns, J-P; Steyaert, J.; Devriendt, K.; Peeters, H.] Univ Louvain, Ctr Human Genet, B-3000 Louvain, Belgium.
[De la Marche, W.; Steyaert, J.] Univ Louvain, Dept Child & Youth Psychiat, B-3000 Louvain, Belgium.
[Steyaert, J.] Univ Limburg, Acad Hosp Maastricht, Dept Clin Genet, Maastricht, Netherlands.
[Steyaert, J.] Maastricht Univ, Res Inst Growth & Dev GROW, Maastricht, Netherlands.
RP Peeters, H (reprint author), Univ Louvain, Ctr Human Genet, Herestr 49, B-3000 Louvain, Belgium.
EM hilde.peeters@med.kuleuven.be
RI Steyaert, Jean/B-5326-2015
OI Steyaert, Jean/0000-0003-2512-4694
FU Fund for Scientific Research-Flanders FWO, Belgium; Interuniversity
Attraction Poles (Belgian State) [GOA 2006/12]; Cure Autism Now (USA)
FX We thank the patients and their family for their cooperation. K. D. is
Senior Clinical Investigator, H. P is post-doctoral researcher, and A. C
and J. B. are aspirants of the Fund for Scientific Research-Flanders
FWO, Belgium. This work is further supported by a grant from
Interuniversity Attraction Poles (Belgian State), GOA 2006/12 and a
grant from Cure Autism Now (USA)
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NR 33
TC 9
Z9 11
PU WILEY-BLACKWELL PUBLISHING, INC
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0009-9163
J9 CLIN GENET
JI Clin. Genet.
PD APR
PY 2010
VL 77
IS 4
BP 389
EP 394
DI 10.1111/j.1399-0004.2009.01318.x
PG 6
WC Genetics & Heredity
SC Genetics & Heredity
GA 570KP
UT WOS:000275674900014
PM 20002455
ER
PT J
AU Back, E
Apperly, IA
AF Back, Elisa
Apperly, Ian A.
TI Two sources of evidence on the non-automaticity of true and false belief
ascription
SO COGNITION
LA English
DT Article
DE Theory of mind; True and false belief; Adult
ID MIND DEVELOPMENT; CHILDS THEORY; ADULTS; COMPREHENSION; KNOWLEDGE;
PRESCHOOLERS; PERSPECTIVE; AUTISM; MEMORY; STATES
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[Apperly, Ian A.] Univ Birmingham, Sch Psychol, Birmingham B15 2TT, W Midlands, England.
RP Back, E (reprint author), Kingston Univ London, Psychol Res Unit, Kingston upon Thames KT1 2EE, Surrey, England.
EM e.back@kingston.ac.uk
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NR 44
TC 24
Z9 25
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0010-0277
J9 COGNITION
JI Cognition
PD APR
PY 2010
VL 115
IS 1
BP 54
EP 70
DI 10.1016/j.cognition.2009.11.008
PG 17
WC Psychology, Experimental
SC Psychology
GA 576EF
UT WOS:000276126400006
PM 20060965
ER
PT J
AU Conty, L
Gimmig, D
Belletier, C
George, N
Huguet, P
AF Conty, Laurence
Gimmig, David
Belletier, Clement
George, Nathalie
Huguet, Pascal
TI The cost of being watched: Stroop interference increases under
concomitant eye contact
SO COGNITION
LA English
DT Article
DE Eye contact effect; Stroop interference; Social perception; Visual
cognition
ID GAZE-DIRECTION; AVERTED GAZE; PERCEPTION; ATTENTION; AUTISM; MEMORY
AB Current models in social neuroscience advance that eye contact may automatically recruit cognitive resources. Here, we directly tested this hypothesis by evaluating the distracting strength of eye contact on concurrent visual processing in the well-known Stroop's paradigm. As expected, participants showed stronger Stroop interference under concomitant eye contact as compared to closed eyes. Two control experiments allowed ruling out low-level account of this effect as well as non-specific effect of the presence of open eyes. This suggests that refraining from processing eye contact is actually as difficult as refraining from word reading in the Stroop task. Crucially, the eye contact effect was obtained while gaze was not under the direct focus of attention and the participants were faced with another powerful distracter (the incongruent word) in the task at hand. Thus, there is a cost of being watched even in circumstances where the processing of direct gaze is strongly disfavored. The present results emphasize the crucial status of eye contact in human cognition. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Conty, Laurence] Ecole Normale Super, INSERM, U970, Cognit Neurosci Lab, F-75005 Paris, France.
[George, Nathalie] Hop La Pitie Salpetriere, Ctr Rech, CNRS, Inst Cerveau Moelle,UMR 7225, F-75651 Paris 13, France.
[George, Nathalie] Univ Paris 06, UPMC, UMR 7225, CRICM,UMRS 975, F-75013 Paris, France.
[Gimmig, David; Belletier, Clement; Huguet, Pascal] Univ Aix Marseille 1, F-13331 Marseille 3, France.
[Gimmig, David; Belletier, Clement; Huguet, Pascal] CNRS, UMR 6146, LPC, F-13331 Marseille 3, France.
RP Conty, L (reprint author), Ecole Normale Super, INSERM, U970, Cognit Neurosci Lab, 29 Rue Ulm, F-75005 Paris, France.
EM laurence.conty@ens.fr
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NR 34
TC 16
Z9 16
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0010-0277
J9 COGNITION
JI Cognition
PD APR
PY 2010
VL 115
IS 1
BP 133
EP 139
DI 10.1016/j.cognition.2009.12.005
PG 7
WC Psychology, Experimental
SC Psychology
GA 576EF
UT WOS:000276126400012
PM 20070959
ER
PT J
AU Sbacchi, S
Acquadro, F
Calo, I
Cali, F
Romano, V
AF Sbacchi, Silvia
Acquadro, Francesco
Calo, Ignazio
Cali, Francesco
Romano, Valentino
TI Functional Annotation of Genes Overlapping Copy Number Variants in
Autistic Patients: Focus on Axon Pathfinding
SO CURRENT GENOMICS
LA English
DT Article
DE Autism Spectrum Disorders; Copy Number Variants; Gene Ontology; axon
guidance signalling; neurodevelopment; candidate genes
ID ADENOMATOUS POLYPOSIS-COLI; SPECTRUM DISORDERS; STRUCTURAL VARIATION;
CHROMOSOMAL REARRANGEMENTS; SUSCEPTIBILITY GENE; ASSOCIATION; GENOME;
EXPRESSION; PATHWAYS; LOCI
AB We have used Gene Ontology (GO) and pathway analyses to uncover the common functions associated to the genes overlapping Copy Number Variants (CNVs) in autistic patients. Our source of data were four published studies [14]. We first applied a two-step enrichment strategy for autism-specific genes. We fished out from the four mentioned studies a list of 2928 genes overall overlapping 328 CNVs in patients and we first selected a sub-group of 2044 genes after excluding those ones that are also involved in CNVs reported in the Database of Genomic Variants (enrichment step 1). We then selected from the step 1-enriched list a sub-group of 514 genes each of which was found to be deleted or duplicated in at least two patients (enrichment step 2). The number of statistically significant processes and pathways identified by the Database for Annotation, Visualization and Integrated Discovery and Ingenuity Pathways Analysis softwares with the step 2-enriched list was significantly higher compared to the step 1-enriched list. In addition, statistically significant GO terms, biofunctions and pathways related to nervous system development and function were exclusively identified by the step 2-enriched list of genes. Interestingly, 21 genes were associated to axon growth and pathfinding. The latter genes and other ones associated to nervous system in this study represent a new set of autism candidate genes deserving further investigation. In summary, our results suggest that the autism's "connectivity genes" in some patients affect very early phases of neurodevelopment, i.e., earlier than synaptogenesis.
C1 [Sbacchi, Silvia; Calo, Ignazio; Romano, Valentino] Univ Palermo, Dipartimento Oncol Sperimentale & Applicaz Clin, Palermo, Italy.
[Acquadro, Francesco] CNIO, Mol Cytogenet Grp, Madrid, Spain.
[Acquadro, Francesco] CIBERER, Madrid, Spain.
[Cali, Francesco; Romano, Valentino] IRCCS, Assoc Oasi Maria SS, Troina, EN, Italy.
RP Romano, V (reprint author), Univ Palermo, Dipartimento Oncol Sperimentale & Applicaz Clin, Via S Lorenzo Colli 312, Palermo, Italy.
EM vromano@unipa.it
FU University of Palermo [ORPA07P5PP]
FX This research was funded by the University of Palermo Grant # "Ex quota
60 %" ORPA07P5PP. Project's title: "Analisi genomica funzionale in
cellule di sangue periferico di pazienti autistici". The Authors wish to
thank Dr. Adam Corner (I. P. A., UK), Dr. Claudia Coronnello, Prof.
Salvatore Micciche and Prof. Rosario Nunzio Mantegna (D. I. F. T. E. R.,
University of Palermo), Dr. Maurizio Elia (Oasi Institute, Troina,
Italy) for their valuable comments and suggestions in the preparation of
this manuscript.
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NR 61
TC 11
Z9 11
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y26, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
EMIRATES
SN 1389-2029
J9 CURR GENOMICS
JI Curr. Genomics
PD APR
PY 2010
VL 11
IS 2
BP 136
EP 145
DI 10.2174/138920210790886880
PG 10
WC Biochemistry & Molecular Biology; Genetics & Heredity
SC Biochemistry & Molecular Biology; Genetics & Heredity
GA 563RC
UT WOS:000275150100006
PM 20885821
ER
PT J
AU Dawson, G
AF Dawson, Geraldine
TI Recent advances in research on early detection, causes, biology, and
treatment of autism spectrum disorders
SO CURRENT OPINION IN NEUROLOGY
LA English
DT Editorial Material
ID PREVALENCE; CHILDREN
C1 [Dawson, Geraldine] Univ N Carolina, Dept Psychiat, Chapel Hill, NC 27599 USA.
[Dawson, Geraldine] Autism Speaks, New York, NY USA.
RP Dawson, G (reprint author), Univ N Carolina, Dept Psychiat, 4120 Bioinformat Bldg,CB 3366, Chapel Hill, NC 27599 USA.
EM gdawson@autismspeaks.org
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[Anonymous], 2009, MMWR SURVEILL SUMM, V58, P1
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Wang K, 2009, NATURE, V459, P528, DOI 10.1038/nature07999
NR 11
TC 8
Z9 8
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1350-7540
J9 CURR OPIN NEUROL
JI Curr. Opin. Neurol.
PD APR
PY 2010
VL 23
IS 2
BP 95
EP 96
DI 10.1097/WCO.0b013e3283377644
PG 2
WC Clinical Neurology; Neurosciences
SC Neurosciences & Neurology
GA 577BU
UT WOS:000276196700001
PM 20216345
ER
PT J
AU Zwaigenbaum, L
AF Zwaigenbaum, Lonnie
TI Advances in the early detection of autism
SO CURRENT OPINION IN NEUROLOGY
LA English
DT Article
DE autism; early diagnosis; infants; longitudinal design; screening
ID PERVASIVE DEVELOPMENTAL DISORDERS; SPECTRUM DISORDERS; HIGH-RISK;
CLINICAL-ASSESSMENT; MODIFIED CHECKLIST; INFANT SIBLINGS;
YOUNG-CHILDREN; 2ND YEAR; TODDLERS; INTERVENTION
AB Purpose of review
Early detection and diagnosis of autism spectrum disorders (ASDs) allows opportunities for children and their families to benefit more fully from early supports and interventions.
Recent findings
Recent advances in early detection research have resulted from prospective studies of high-risk infants and large ASD screening studies conducted in community settings. With improvement in early detection of autism, exciting progress has been made in establishing the efficacy of ASD-specific interventions for toddlers as young as 18 months on the basis of controlled clinical trials.
Summary
There has been increasing emphasis on opportunities to link early behavioral expression to the underlying neurobiology of ASD, potentially bringing us closer to the fundamental mechanisms underlying this disorder.
C1 [Zwaigenbaum, Lonnie] Univ Alberta, Glenrose Rehabil Hosp, Dept Pediat, Edmonton, AB T5G 0B7, Canada.
RP Zwaigenbaum, L (reprint author), Univ Alberta, Glenrose Rehabil Hosp E209, Dept Pediat, 10230-111 Ave, Edmonton, AB T5G 0B7, Canada.
EM lonnie.zwaigenbaum@albertahealthservices.ca
FU Alberta Heritage Foundation for Medical Research
FX Dr. Zwaigenbaum holds the Stollery Children's Hospital Foundation
Endowed Chair in Autism Research and is supported by a Health Scholar
Award from the Alberta Heritage Foundation for Medical Research.
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NR 61
TC 25
Z9 25
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1350-7540
J9 CURR OPIN NEUROL
JI Curr. Opin. Neurol.
PD APR
PY 2010
VL 23
IS 2
BP 97
EP 102
DI 10.1097/WCO.0b013e3283372430
PG 6
WC Clinical Neurology; Neurosciences
SC Neurosciences & Neurology
GA 577BU
UT WOS:000276196700002
PM 20154615
ER
PT J
AU Herbert, MR
AF Herbert, Martha R.
TI Contributions of the environment and environmentally vulnerable
physiology to autism spectrum disorders
SO CURRENT OPINION IN NEUROLOGY
LA English
DT Article
DE autism; dynamic encephalopathy; environment; glutathione; oxidative
stress; pathophysiology
ID INCLUDING DEVELOPMENTAL IMMUNOTOXICITY; BLOOD-BRAIN-BARRIER; DIAGNOSTIC
SUBSTITUTION; IMMUNE-RESPONSE; PRENATAL STRESS; ONSET AUTISM; CHILDREN;
PREVALENCE; VACCINES; EXPOSURE
AB Purpose of review
This review presents a rationale and evidence for contributions of environmental influences and environmentally vulnerable physiology to autism spectrum disorders (ASDs).
Recent findings
Recent studies suggest a substantial increase in ASD prevalence above earlier Centers for Disease Control figures of one in 150, only partly explicable by data artifacts, underscoring the possibility of environmental contributors to increased prevalence. Some gene variants in ASD confer altered vulnerability to environmental stressors and exposures. De-novo mutations and advanced parental age as a risk factor for ASD also suggest a role for environment. Systemic and central nervous system pathophysiology, including oxidative stress, neuroinflammation, and mitochondrial dysfunction can be consistent with a role for environmental influence (e. g. from air pollution, organophosphates, heavy metals) in ASD, and some of the underlying biochemical disturbances (such as abnormalities in glutathione, a critical antioxidant and detoxifier) can be reversed by targeted nutritional interventions. Dietary factors and food contaminants may contribute risk. Improvement and loss of diagnosis in some with ASD suggest brain circuitry amenable to environmental modulation.
Summary
Prevalence, genetic, exposure, and pathophysiological evidence all suggest a role for environmental factors in the inception and lifelong modulation of ASD. This supports the need for seeking targets for early and ongoing medical prevention and treatment of ASD.
C1 Massachusetts Gen Hosp, TRANSCEND Res Program, Charlestown, MA 02129 USA.
RP Herbert, MR (reprint author), Massachusetts Gen Hosp, TRANSCEND Res Program, 149 13th St,Room 10-018, Charlestown, MA 02129 USA.
EM mherbert1@partners.org
FU National Institute of Health (NINDS); Department of Defense Autism
Spectrum Disorders Research Program; Nancy Lurie Marks Family
Foundation; Autism Society
FX The present study was supported by National Institute of Health (NINDS),
Department of Defense Autism Spectrum Disorders Research Program, Nancy
Lurie Marks Family Foundation, Autism Society.
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NR 102
TC 87
Z9 92
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1350-7540
EI 1473-6551
J9 CURR OPIN NEUROL
JI Curr. Opin. Neurol.
PD APR
PY 2010
VL 23
IS 2
BP 103
EP 110
DI 10.1097/WCO.0b013e328336a01f
PG 8
WC Clinical Neurology; Neurosciences
SC Neurosciences & Neurology
GA 577BU
UT WOS:000276196700003
PM 20087183
ER
PT J
AU Goines, P
Van de Water, J
AF Goines, Paula
Van de Water, Judy
TI The immune system's role in the biology of autism
SO CURRENT OPINION IN NEUROLOGY
LA English
DT Article
DE autism; autoantibodies; cytokines; immune system; immunoglobulin
ID MIGRATION INHIBITORY FACTOR; SPECTRUM DISORDERS; UNAFFECTED SIBLINGS;
FETAL-BRAIN; ANTIBRAIN ANTIBODIES; CYTOKINE PRODUCTION; CHILDREN;
AUTOANTIBODIES; AUTOIMMUNITY; RESPONSES
AB Purpose of review
The following is a review of the most recent research concerning the potential role of immune system dysfunction in autism. This body of literature has expanded dramatically over the past few years as researchers continue to identify immune anomalies in individuals with autism.
Recent findings
The most exciting of these recent findings is the discovery of autoantibodies targeting brain proteins in both children with autism and their mothers. In particular, circulating maternal autoantibodies directed toward fetal brain proteins are highly specific for autism. This finding has great potential as a biomarker for disease risk and may provide an avenue for future therapeutics and prevention. Additionally, data concerning the cellular immune system in children with autism suggest there may be a defect in signaling pathways that are shared by the immune and central nervous systems. Although studies to explore this hypothesis are ongoing, there is great interest in the commonalities between the neural and immune systems and their extensive interactions.
Summary
In summary, the exciting research regarding the role of the immune system in autism spectrum disorders may have profound implications for diagnosis and treatment of this devastating disease.
C1 [Goines, Paula; Van de Water, Judy] Univ Calif Davis, Div Rheumatol Allergy & Clin Immunol, Davis, CA 95616 USA.
[Goines, Paula; Van de Water, Judy] Univ Calif Davis, MIND Inst, Davis, CA 95616 USA.
[Goines, Paula; Van de Water, Judy] Univ Calif Davis, NIEHS, Ctr Childrens Environm Hlth, Davis, CA 95616 USA.
RP Van de Water, J (reprint author), Div Rheumatol, 451 Hlth Sci Dr, Davis, CA 95616 USA.
EM javandewater@ucdavis.edu
FU NIEHS [1 P01 ES11269-01, 1 R01-ES015359]; U. S. Environmental Protection
Agency (U. S. EPA) [R829388]; UC Davis M. I. N. D. Institute; Autism
Speaks
FX The author's studies cited herein were supported by grants NIEHS 1 P01
ES11269-01, the U. S. Environmental Protection Agency (U. S. EPA)
through the Science to Achieve Results (STAR) program (grant R829388),
NIEHS 1 R01-ES015359, the UC Davis M. I. N. D. Institute, and Autism
Speaks.
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NR 73
TC 77
Z9 78
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1350-7540
J9 CURR OPIN NEUROL
JI Curr. Opin. Neurol.
PD APR
PY 2010
VL 23
IS 2
BP 111
EP 117
DI 10.1097/WCO.0b013e3283373514
PG 7
WC Clinical Neurology; Neurosciences
SC Neurosciences & Neurology
GA 577BU
UT WOS:000276196700004
PM 20160651
ER
PT J
AU Rubenstein, JLR
AF Rubenstein, John L. R.
TI Three hypotheses for developmental defects that may underlie some forms
of autism spectrum disorder
SO CURRENT OPINION IN NEUROLOGY
LA English
DT Article
DE autism; brain development; cortex size; excitation/inhibition ratio;
frontal cortex; genetics; sex steroid
ID DLX GENES; CEREBRAL-CORTEX; FRONTAL-CORTEX; DEVELOPING FOREBRAIN;
HOMEOBOX GENES; DIFFERENTIATION; MIGRATION; FGF17; BRAIN; MICE
AB Purpose of review
Molecular and genetic insights into the etiology of autism spectrum disorders are now available. The field now needs to understand how these perturbations affect development and function of the brain.
Recent findings
Herein I review the genetic mechanisms known to predispose to autism spectrum disorders, and attempt to consolidate many of these within cellular/molecular pathways that regulate development of neural systems that underlie cognition and social behaviors. In addition to the clear relationship of many susceptibility genes to activity-dependent neural responses, I propose the existence of three additional mechanisms that may contribute to autism spectrum disorders: evolutionary-driven expansion of cerebrum and cerebellar size; imbalance in the excitatory/inhibitory ratio in local and extended circuits; the hormonal effects of the male genotype.
Summary
Understanding these mechanisms opens the possibility to therapeutic interventions.
C1 Univ Calif San Francisco, Nina Ireland Lab Dev Neurobiol, Ctr Neurobiol & Psychiat, Dept Psychiat, San Francisco, CA 94158 USA.
RP Rubenstein, JLR (reprint author), Univ Calif San Francisco, Nina Ireland Lab Dev Neurobiol, Ctr Neurobiol & Psychiat, Dept Psychiat, Rock Hall,Room RH 284C,UCSF MC 2611,1550 4th St, San Francisco, CA 94158 USA.
EM john.rubenstein@ucsf.edu
FU Nina Ireland; Simons and Weston Havens Foundations; NINDS; NIMH
FX JLRR is funded by Nina Ireland, the Simons and Weston Havens
Foundations, NINDS and NIMH. I thank Susan Yu for her help with the
references.
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NR 62
TC 55
Z9 57
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1350-7540
J9 CURR OPIN NEUROL
JI Curr. Opin. Neurol.
PD APR
PY 2010
VL 23
IS 2
BP 118
EP 123
DI 10.1097/WCO.0b013e328336eb13
PG 6
WC Clinical Neurology; Neurosciences
SC Neurosciences & Neurology
GA 577BU
UT WOS:000276196700005
PM 20087182
ER
PT J
AU Minshew, NJ
Keller, TA
AF Minshew, Nancy J.
Keller, Timothy A.
TI The nature of brain dysfunction in autism: functional brain imaging
studies
SO CURRENT OPINION IN NEUROLOGY
LA English
DT Article
DE autism; connectivity; fMRI
ID SENTENCE COMPREHENSION; SPECTRUM DISORDERS; DEFAULT NETWORK;
CONNECTIVITY; UNDERCONNECTIVITY; FMRI; SYNCHRONIZATION; ABNORMALITIES;
PERFORMANCE; CHILDREN
AB Purpose of review
Functional magnetic resonance imaging studies have had a profound impact on the delineation of the neurobiologic basis for autism. Advances in fMRI technology for investigating functional connectivity, resting state connectivity, and a default mode network have provided further detail about disturbances in brain organization and brain-behavior relationships in autism to be reviewed in this article.
Recent findings
Recent fMRI studies have provided evidence of enhanced activation and connectivity of posterior, or parietal-occipital, networks and enhanced reliance on visuospatial abilities for visual and verbal reasoning in high functioning individuals with autism. Evidence also indicates altered activation in frontostriatal networks for cognitive control, particularly involving anterior cingulate cortex, and altered connectivity in the resting state and the default mode network. The findings suggest that the specialization of many cortical networks of the human brain has failed to develop fully in high functioning individuals with autism.
Summary
This research provides a growing specification of to the neurobiologic basis for this complex syndrome and for the co-occurrence of the signs and symptoms as a syndrome. With this knowledge has come new neurobiologically based opportunities for intervention.
C1 [Minshew, Nancy J.] Univ Pittsburgh, Sch Med, Pittsburgh, PA 15213 USA.
[Keller, Timothy A.] Carnegie Mellon Univ, Ctr Cognit Brain Imaging, Pittsburgh, PA 15213 USA.
RP Minshew, NJ (reprint author), Univ Pittsburgh, Sch Med, Webster Hall,Suite 300,3811 OHara St, Pittsburgh, PA 15213 USA.
EM minshewnj@upmc.edu
FU NIH [HD055748]
FX This work is funded by NIH HD055748.
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NR 40
TC 89
Z9 89
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1350-7540
J9 CURR OPIN NEUROL
JI Curr. Opin. Neurol.
PD APR
PY 2010
VL 23
IS 2
BP 124
EP 130
DI 10.1097/WCO.0b013e32833782d4
PG 7
WC Clinical Neurology; Neurosciences
SC Neurosciences & Neurology
GA 577BU
UT WOS:000276196700006
PM 20154614
ER
PT J
AU Coury, D
AF Coury, Daniel
TI Medical treatment of autism spectrum disorders
SO CURRENT OPINION IN NEUROLOGY
LA English
DT Article
DE autism spectrum disorders; epilepsy; gastrointestinal conditions;
genetic testing; immune function; medical treatment
ID FRAGILE-X-SYNDROME; GASTROINTESTINAL SYMPTOMS; EPILEPTIFORM DISCHARGES;
BEHAVIORAL TREATMENT; TYPICAL DEVELOPMENT; ROLANDIC EPILEPSY; EEG
ABNORMALITIES; SLEEP PROBLEMS; CHILDREN; REGRESSION
AB Purpose of review
There are several common medical conditions occurring in people with autism spectrum disorders (ASD) that can benefit from treatment and can in turn improve the health and quality of life of people with ASD. This review will primarily focus on these medical comorbidities, with a brief review of potential future treatments.
Recent findings
There continues to be disagreement regarding the exact prevalence and etiological significance of gastrointestinal conditions, epilepsy and other abnormal electroencephalographic findings, and sleep problems. It is not clear whether gastrointestinal conditions occur more frequently than in typically developing children, and whether there are distinct conditions that occur more often in ASD than in non-ASD populations. Abnormal electroencephalographic findings have been reported in up to 60% of children with ASD, and some believe that these abnormalities may be responsible for parts of the ASD phenotype. Sleep problems are reported more frequently than in the general population, and effective treatments are available. Future medical treatments for ASD may be directed at underlying core symptoms and have greater impact than today's symptomatic approach.
Summary
Further research in these areas is needed to better guide diagnosis and treatment of a variety of medical conditions experienced by people with ASD.
C1 [Coury, Daniel] Ohio State Univ, Coll Med Dev & Behav Pediat, Dept Pediat, Nationwide Childrens Hosp, Columbus, OH 43205 USA.
RP Coury, D (reprint author), Ohio State Univ, Coll Med, Dept Pediat, 700 Childrens Dr,Timken G-350, Columbus, OH 43205 USA.
EM Daniel.Coury@NationwideChildrens.org
RI Coury, Daniel/E-2925-2011
FU U. S. Department of Health and Human Services, Health Resources and
Services Administration, Maternal and Child Health Research Program [UA3
MC 11054]
FX This work was supported in part by the following: Autism Speaks and a
cooperative agreement (UA3 MC 11054) from the U. S. Department of Health
and Human Services, Health Resources and Services Administration,
Maternal and Child Health Research Program, to the Massachusetts General
Hospital.
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NR 52
TC 13
Z9 13
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1350-7540
J9 CURR OPIN NEUROL
JI Curr. Opin. Neurol.
PD APR
PY 2010
VL 23
IS 2
BP 131
EP 136
DI 10.1097/WCO.0b013e32833722fa
PG 6
WC Clinical Neurology; Neurosciences
SC Neurosciences & Neurology
GA 577BU
UT WOS:000276196700007
PM 20087181
ER
PT J
AU Kasari, C
Lawton, K
AF Kasari, Connie
Lawton, Kathy
TI New directions in behavioral treatment of autism spectrum disorders
SO CURRENT OPINION IN NEUROLOGY
LA English
DT Article
DE autism; behavior; intervention
ID HIGH-FUNCTIONING AUTISM; IMPROVISATIONAL MUSIC-THERAPY; EXCHANGE
COMMUNICATION-SYSTEM; JOINT ATTENTION; YOUNG-CHILDREN; SOCIAL
INTERACTIONS; TEACHING-CHILDREN; ASPERGER-SYNDROME; CONTROLLED-TRIAL;
PLAY SKILLS
AB Purpose of review
The review explores current trends in the behavioral intervention literature for children with an autism spectrum disorder (ASD) during 2008 and 2009. Noteworthy findings and intervention strategies are highlighted. Additionally, the quality of all reviewed studies is systematically evaluated.
Recent findings During 2008 and 2009, there was nearly a quarter increase in the number of behavioral intervention studies, as well as more randomized controlled trials and approaches other than applied behavior analysis. Many of the studies investigated commonly used ASD intervention practices or novel treatments. A few were conducted with underserved populations, such as toddlers and adults with ASD. Social impairment was the focus of the largest number of intervention studies. A small percentage of studies were rated as high-quality.
Summary
Overall, the reviewed studies suggest that ASD-specific deficits can be improved through behavioral intervention. However, whereas progress continues to be made in our understanding of effective treatments for children with ASD, confidence in these findings would be improved with higher-quality studies.
C1 [Kasari, Connie] Univ Calif Los Angeles, Semel Inst 68 268, Ctr Autism Res & Treatment, Los Angeles, CA 90024 USA.
RP Kasari, C (reprint author), Univ Calif Los Angeles, Semel Inst 68 268, Ctr Autism Res & Treatment, Los Angeles, CA 90024 USA.
EM kasari@gseis.ucla.edu
RI Lawton, Kathy/D-7835-2012
FU U. S. Dept. of Health and Human Services HRSA, Maternal and Child Health
Branch [UA3MC11055]; NIH [R01 MH084864]
FX The research was supported by the Autism Intervention Research-Network
funded by U. S. Dept. of Health and Human Services HRSA, Maternal and
Child Health Branch, Grant # UA3MC11055, Autism Speaks grant on
Characterizing Cognition in Nonverbal Individuals with Autism, and NIH
R01 MH084864 to Connie Kasari. We also appreciate the research
assistance of Marina Farberov and Janet Bang.
CR American Psychiatric Association, DIAGN STAT MAN MENT
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NR 77
TC 29
Z9 29
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1350-7540
J9 CURR OPIN NEUROL
JI Curr. Opin. Neurol.
PD APR
PY 2010
VL 23
IS 2
BP 137
EP 143
DI 10.1097/WCO.0b013e32833775cd
PG 7
WC Clinical Neurology; Neurosciences
SC Neurosciences & Neurology
GA 577BU
UT WOS:000276196700008
PM 20160648
ER
PT J
AU Ess, KC
AF Ess, Kevin C.
TI Tuberous sclerosis complex: a brave new world?
SO CURRENT OPINION IN NEUROLOGY
LA English
DT Article
DE autism; cortical development; epilepsy; mammalian target of rapamycin;
mammalian target of rapamycin complex 1; progenitor cell; tuber
ID MUTATIONAL ANALYSIS; TUMOR-DEVELOPMENT; INFANTILE SPASMS; MOUSE MODEL;
TSC2 GENES; RAPAMYCIN; MTOR; MICE; EPILEPSY; LYMPHANGIOLEIOMYOMATOSIS
AB Purpose of review
Tuberous sclerosis complex (TSC) is a multiorgan genetic disease caused by mutations in the TSC1 or TSC2 genes. TSC has been recognized for many years as an important cause of severe neurological disease with patients suffering from epilepsy, developmental delay, autism, and psychiatric problems. During the last year, there have been enormous advances in basic and translational research pertaining to TSC.
Recent findings
In this review, I discuss the basic science findings that position the TSC1 and TSC2 genes as critical regulators of the mammalian target of rapamycin kinase within mammalian target of rapamycin complex 1. In addition, I will discuss the development of new animal models, translational data, and recent clinical trials using mammalian target of rapamycin complex 1 inhibitors such as rapamycin.
Summary
The past few years have seen spectacular advances that have energized TSC-related research and challenged existing symptomatic treatments. Although it remains to be seen whether use of mammalian target of rapamycin complex 1 inhibitors will revolutionize the care of patients with TSC, the application of basic and translational research towards a specific clinical disorder emphasizes the potential and promise of molecular medicine.
C1 [Ess, Kevin C.] Vanderbilt Univ, Med Ctr, Dept Neurol, Nashville, TN 37232 USA.
[Ess, Kevin C.] Vanderbilt Univ, Vanderbilt Kennedy Ctr Res Human Dev, Nashville, TN 37232 USA.
RP Ess, KC (reprint author), Vanderbilt Univ, Med Ctr, Dept Neurol, 465 21st Ave S,MRBIII 6158, Nashville, TN 37232 USA.
EM kevin.ess@vanderbilt.edu
FU National Institute of Neurological Disorders and Stroke (NINDS);
National Institutes of Health (NIH); Tuberous Sclerosis Alliance;
Vanderbilt Kennedy Center for Research on Human Development
FX Dr Ess is supported by the National Institute of Neurological Disorders
and Stroke (NINDS), National Institutes of Health (NIH), and the
Tuberous Sclerosis Alliance. The support was also provided by the
Vanderbilt Kennedy Center for Research on Human Development.
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NR 35
TC 16
Z9 18
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1350-7540
J9 CURR OPIN NEUROL
JI Curr. Opin. Neurol.
PD APR
PY 2010
VL 23
IS 2
BP 189
EP 193
DI 10.1097/WCO.0b013e32832c4ff5
PG 5
WC Clinical Neurology; Neurosciences
SC Neurosciences & Neurology
GA 577BU
UT WOS:000276196700016
PM 20087180
ER
PT J
AU Landrigan, PJ
AF Landrigan, Philip J.
TI What causes autism? Exploring the environmental contribution
SO CURRENT OPINION IN PEDIATRICS
LA English
DT Review
DE autism; developmental neurotoxicity; national children's study; toxicity
testing; vaccines
ID ORGANOPHOSPHATE PESTICIDE EXPOSURE; CHILDRENS INTELLECTUAL FUNCTION;
MEXICAN-AMERICAN CHILDREN; DEVELOPMENTAL NEUROTOXICITY; IN-UTERO;
POLYCHLORINATED-BIPHENYLS; THIMEROSAL EXPOSURE; RUBELLA VACCINATION;
SPECTRUM DISORDERS; DEVELOPING BRAIN
AB Purpose of review
Autism is a biologically based disorder of brain development. Genetic factors - mutations, deletions, and copy number variants - are clearly implicated in causation of autism. However, they account for only a small fraction of cases, and do not easily explain key clinical and epidemiological features. This suggests that early environmental exposures also contribute. This review explores this hypothesis.
Recent findings
Indirect evidence for an environmental contribution to autism comes from studies demonstrating the sensitivity of the developing brain to external exposures such as lead, ethyl alcohol and methyl mercury. But the most powerful proof-of-concept evidence derives from studies specifically linking autism to exposures in early pregnancy - thalidomide, misoprostol, and valproic acid; maternal rubella infection; and the organophosphate insecticide, chlorpyrifos. There is no credible evidence that vaccines cause autism.
Summary
Expanded research is needed into environmental causation of autism. Children today are surrounded by thousands of synthetic chemicals. Two hundred of them are neurotoxic in adult humans, and 1000 more in laboratory models. Yet fewer than 20% of high-volume chemicals have been tested for neurodevelopmental toxicity. I propose a targeted discovery strategy focused on suspect chemicals, which combines expanded toxicological screening, neurobiological research and prospective epidemiological studies.
C1 Mt Sinai Sch Med, Childrens Environm Hlth Ctr, Dept Pediat, Dept Community & Prevent Med, New York, NY 10029 USA.
RP Landrigan, PJ (reprint author), Mt Sinai Sch Med, Childrens Environm Hlth Ctr, Dept Pediat, Dept Community & Prevent Med, 1 Gustave L Levy Pl,Box 1057, New York, NY 10029 USA.
EM phil.landrigan@mssm.edu
FU NIEHS [5P01ES9584]; EPA [RD-83171101]
FX The work was supported by NIEHS grant number 5P01ES9584 and EPA grant
number RD-83171101.
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NR 82
TC 103
Z9 105
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1040-8703
J9 CURR OPIN PEDIATR
JI CURR. OPIN. PEDIATR.
PD APR
PY 2010
VL 22
IS 2
BP 219
EP 225
DI 10.1097/MOP.0b013e328336eb9a
PG 7
WC Pediatrics
SC Pediatrics
GA 578XQ
UT WOS:000276330900016
PM 20087185
ER
PT J
AU Gonzales, ML
LaSalle, JM
AF Gonzales, Michael L.
LaSalle, Janine M.
TI The Role of MeCP2 in Brain Development and Neurodevelopmental Disorders
SO CURRENT PSYCHIATRY REPORTS
LA English
DT Article
DE Rett syndrome; Angelman's syndrome; Autism; Epigenetic;
Neurodevelopmental
ID X-CHROMOSOME INACTIVATION; CPG-BINDING PROTEIN-2; LINKED
MENTAL-RETARDATION; RETT-SYNDROME; MOUSE MODEL; NEUROLOGICAL SYMPTOMS;
MUTATIONS; PHENOTYPE; MICE; TRANSCRIPTION
AB Methyl CpG binding protein-2 (MeCP2) is an essential epigenetic regulator in human brain development. Rett syndrome, the primary disorder caused by mutations in the X-linked MECP2 gene, is characterized by a period of cognitive decline and development of hand stereotypies and seizures following an apparently normal early infancy. In addition, MECP2 mutations and duplications are observed in a spectrum of neurodevelopmental disorders, including severe neonatal encephalopathy, X-linked mental retardation, and autism, implicating MeCP2 as an essential regulator of postnatal brain development. In this review, we compare the mutation types and inheritance patterns of the human disorders associated with MECP2. In addition, we summarize the current understanding of MeCP2 as a central epigenetic regulator of activity-dependent synaptic maturation. As MeCP2 occupies a central role in the pathogenesis of multiple neurodevelopmental disorders, continued investigation into MeCP2 function and regulatory pathways may show promise for developing broad-spectrum therapies.
C1 [Gonzales, Michael L.; LaSalle, Janine M.] Univ Calif Davis, Sch Med Med Microbiol & Immunol, Davis, CA 95616 USA.
RP LaSalle, JM (reprint author), Univ Calif Davis, Sch Med Med Microbiol & Immunol, 1 Shields Ave, Davis, CA 95616 USA.
EM migonzales@ucdavis.edu; jmlasalle@ucdavis.edu
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NR 52
TC 70
Z9 71
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1523-3812
J9 CURR PSYCHIAT REP
JI Curr. Psychiatry Rep.
PD APR
PY 2010
VL 12
IS 2
BP 127
EP 134
DI 10.1007/s11920-010-0097-7
PG 8
WC Psychiatry
SC Psychiatry
GA 752YK
UT WOS:000289731200009
PM 20425298
ER
PT J
AU Patterson, SY
Smith, V
Jelen, M
AF Patterson, Stephanie Y.
Smith, Veronica
Jelen, Michaela
TI Behavioural intervention practices for stereotypic and repetitive
behaviour in individuals with autism spectrum disorder: a systematic
review
SO DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY
LA English
DT Review
ID SINGLE-SUBJECT RESEARCH; NONCONTINGENT REINFORCEMENT; PSYCHOSOCIAL
INTERVENTIONS; RESPONSE BLOCKING; CHILDREN; STIMULATION; METHODOLOGY;
VALIDATION; EFFICACY
AB AIM The purpose of this systematic review was to examine the quality of conduct of experimental studies contributing to our empirical understanding of function-based behavioural interventions for stereotypic and repetitive behaviours (SRBs) in individuals with autism spectrum disorders (ASDs).
METHOD Systematic review methodology was used to identify relevant articles, to rate the level of evidence and quality of conduct of the studies, and to extract data systematically.
RESULTS Ten single case studies examining 17 participants (14 males, 3 females; age 2y 11mo-26y) diagnosed with various ASDs were included. Overall, studies reported decreases in SRBs using behavioural interventions and some collateral increase in desirable behaviours.
INTERPRETATION Only a small number of intervention studies for SRBs explicitly state the function of the behaviour; therefore, relatively little is known about the efficacy of SRB interventions in relation to the range of possible behavioural functions. Evidence supporting SRB interventions is preliminary in nature, and caution should be used in choosing and implementing SRB intervention practices for individuals with ASDs.
C1 [Patterson, Stephanie Y.; Smith, Veronica; Jelen, Michaela] Univ Alberta, Dept Educ Psychol, Fac Educ, Edmonton, AB T6G 2G5, Canada.
RP Patterson, SY (reprint author), Univ Alberta, Dept Educ Psychol, Fac Educ, 6-123F Educ N, Edmonton, AB T6G 2G5, Canada.
EM syp1@ualberta.ca
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NR 52
TC 9
Z9 9
PU WILEY-BLACKWELL PUBLISHING, INC
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0012-1622
J9 DEV MED CHILD NEUROL
JI Dev. Med. Child Neurol.
PD APR
PY 2010
VL 52
IS 4
BP 318
EP 327
DI 10.1111/j.1469-8749.2009.03597.x
PG 10
WC Clinical Neurology; Pediatrics
SC Neurosciences & Neurology; Pediatrics
GA 564HY
UT WOS:000275205100005
PM 20412248
ER
PT J
AU Giarelli, E
Wiggins, LD
Rice, CE
Levy, SE
Kirby, RS
Pinto-Martin, J
Mandell, D
AF Giarelli, Ellen
Wiggins, Lisa D.
Rice, Catherine E.
Levy, Susan E.
Kirby, Russell S.
Pinto-Martin, Jennifer
Mandell, David
TI Sex differences in the evaluation and diagnosis of autism spectrum
disorders among children
SO DISABILITY AND HEALTH JOURNAL
LA English
DT Article
DE Autism spectrum disorder; Children; Sex differences
ID PERVASIVE DEVELOPMENTAL DISORDERS; EARLY IDENTIFICATION; CHILDHOOD
AUTISM; PREVALENCE; SURVEILLANCE; DISABILITIES; CHALLENGES; INTERVIEW;
SAMPLE; AGE
AB Background: One of the most consistent features of the autism spectrum disorders (ASDs) is the predominance among males, with approximately four males to every female. We sought to examine sex differences among children who met case definition for ASD in a large, population-based cohort with respect to age at first developmental evaluation, age of diagnosis, influence of cognitive impairment on these outcomes, and sex-specific behavioral characteristics.
Methods: We conducted a secondary analysis of data collected for a population-based study of the prevalence of ASD. The sample comprised 2,568 children born in 1994 who met the case definition of ASD as established by the Autism and Developmental Disabilities Monitoring (ADDM) Network for ASD surveillance. Children who had a history of developmental disability and behavioral features consistent with the DSM-IV-TR criteria for autistic disorder, Asperger's disorder, and Pervasive Developmental Disorder Not Otherwise Specified in existing evaluation records were classified as ASD cases via two paths: streamlined and nonstreamlined. Streamlined reviews were conducted if there was an ASD diagnosis documented in the records. Data were collected in 13 sites across the United States through the ADDM Network, funded by the Centers for Disease Control and Prevention.
Results: Males constituted 81% of the sample. There were no differences by sex in average age at first evaluation or average age of diagnosis among those with an existing documented chart diagnosis of an ASD. Girls were less likely than boys to have a documented diagnosis (odds ratio [OR] = 0.76, p = .004). This analysis was adjusted for cognitive impairment status. In the logistic model, with the interaction term for sex and cognitive impairment, girls with IQ of 70 or less were less likely than boys with IQ of 70 or less to have a documented diagnosis (OR = 0.70, 95% confidence interval [CI] = 0.50-0.97, p = .035). Boys with IQ greater than 70 were less likely than boys with IQ of 70 or less to have a documented diagnosis (OR = 0.60, 95% CI = 0.49-0.74, p < .001). This finding (less likely to have a documented diagnosis) was also true for girls with IQ greater than 70 (OR = 0.45, 95% CI = 0.32-0.66, p < .001). Girls were more likely to have notations of seizure-like behavior (p < .001). Boys were more likely to have notations of hyperactivity or a short attention span and aggressive behavior (p < .01).
Conclusions: Girls, especially those without cognitive impairment, may be formally identified at a later age than boys. This may delay referral for early intervention. Community education efforts should alert clinicians and parents to the potential of ASDs in boys and girls. (C) 2010 Elsevier Inc. All rights reserved.
C1 [Giarelli, Ellen; Pinto-Martin, Jennifer] Univ Penn, Sch Nursing, Div Biobehav Hlth Syst, Philadelphia, PA 19104 USA.
[Wiggins, Lisa D.; Rice, Catherine E.] Ctr Dis Control & Prevent, Dev Disabil Branch, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USA.
[Levy, Susan E.] Childrens Hosp Philadelphia, Div Child Dev Rehabil & Metab Dis, Reg Autism Ctr, Philadelphia, PA 19104 USA.
[Kirby, Russell S.] Univ S Florida, Coll Publ Hlth, Dept Community & Family Hlth, Tampa, FL 33647 USA.
[Mandell, David] Univ Penn, Childrens Hosp Philadelphia, Sch Med, Ctr Autism Res, Philadelphia, PA 19104 USA.
[Kirby, Russell S.] Univ Alabama, Birmingham, AL USA.
EM giarelli@nursing.upenn.edu
RI Mandell, David/H-2730-2012
OI Mandell, David/0000-0001-8240-820X
FU Centers for Disease Control and Prevention (CDC)
FX The authors of this manuscript were principal investigators or
co-investigators participating in the ADDM Network Surveillance Project.
The principal investigators and co-investigators received salary support
over several years during the collection of data that was provided by
the Centers for Disease Control and Prevention (CDC). There are no
conflicts of interest, financial or otherwise, relevant to the subject
matter of the manuscript that have occurred over the last 2 years or
that are expected in the foreseeable future, beyond participation in the
ADDM network. These projects were funded by the CDC. The findings and
conclusions in this report are those of the authors and do not
necessarily represent the views of the CDC. For additional information,
see www.cdc.gov/autism.
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NR 38
TC 50
Z9 50
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1936-6574
J9 DISABIL HEALTH J
JI Disabil. Health J.
PD APR
PY 2010
VL 3
IS 2
BP 107
EP 116
DI 10.1016/j.dhjo.2009.07.001
PG 10
WC Health Care Sciences & Services; Health Policy & Services; Public,
Environmental & Occupational Health; Rehabilitation
SC Health Care Sciences & Services; Public, Environmental & Occupational
Health; Rehabilitation
GA 668QO
UT WOS:000283284900007
PM 21122776
ER
PT J
AU Neubauer, BA
AF Neubauer, B. A.
TI AUTISM AND EPILEPSY
SO EPILEPSIA
LA English
DT Meeting Abstract
CT 50th Meeting of the German-Society-Against-Epilepsy
CY APR 28-MAY 01, 2010
CL Wiesbaden, GERMANY
SP German Soc Against Epilepsy
C1 [Neubauer, B. A.] Univ Giessen, Giessen, Germany.
NR 0
TC 0
Z9 0
PU WILEY-BLACKWELL PUBLISHING, INC
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0013-9580
J9 EPILEPSIA
JI Epilepsia
PD APR
PY 2010
VL 51
SU 2
BP 16
EP 17
PG 2
WC Clinical Neurology
SC Neurosciences & Neurology
GA 586PP
UT WOS:000276923600057
ER
PT J
AU Taurines, R
Dudley, E
Conner, AC
Grassl, J
Jans, T
Guderian, F
Mehler-Wex, C
Warnke, A
Gerlach, M
Thome, J
AF Taurines, Regina
Dudley, Edward
Conner, Alexander C.
Grassl, Julia
Jans, Thomas
Guderian, Frank
Mehler-Wex, Claudia
Warnke, Andreas
Gerlach, Manfred
Thome, Johannes
TI Serum protein profiling and proteomics in autistic spectrum disorder
using magnetic bead-assisted mass spectrometry
SO EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
LA English
DT Article
DE Autism; Biomarker discovery; Serum profiling; Proteomics
ID INFANTILE-AUTISM; SEROTONIN TRANSPORTER; MENTAL-RETARDATION; NEONATAL
BLOOD; CHILDREN; CANCER; NOREPINEPHRINE; NEUROTROPHINS; NEUROPEPTIDES;
MARKERS
AB The pathophysiology of autistic spectrum disorder (ASD) is not fully understood and there are no diagnostic or predictive biomarkers. Proteomic profiling has been used in the past for biomarker research in several non-psychiatric and psychiatric disorders and could provide new insights, potentially presenting a useful tool for generating such biomarkers in autism. Serum protein pre-fractionation with C8-magnetic beads and protein profiling by matrix-assisted laser desorption/ionisation-time of flight-mass spectrometry (MALDI-ToF-MS) were used to identify possible differences in protein profiles in patients and controls. Serum was obtained from 16 patients (aged 8-18) and age-matched controls. Three peaks in the MALDI-ToF-MS significantly differentiated the ASD sample from the control group. Sub-grouping the ASD patients into children with and without comorbid Attention Deficit and Hyperactivity Disorder, ADHD (ASD/ADHD+ patients, n = 9; ASD/ADHD- patients, n = 7), one peak distinguished the ASD/ADHD+ patients from controls and ASD/ADHD- patients. Our results suggest that altered protein levels in peripheral blood of patients with ASD might represent useful biomarkers for this devastating psychiatric disorder.
C1 [Taurines, Regina; Conner, Alexander C.; Grassl, Julia; Thome, Johannes] Swansea Univ, Sch Med, Inst Life Sci, Acad Unit Psychiat, Swansea SA2 8PP, W Glam, Wales.
[Dudley, Edward] Swansea Univ, SOTEAS, Biochem Res Grp, Swansea SA2 8PP, W Glam, Wales.
[Jans, Thomas; Guderian, Frank; Warnke, Andreas; Gerlach, Manfred] Univ Wurzburg, Dept Child & Adolescent Psychiat & Psychotherapy, Wurzburg, Germany.
[Mehler-Wex, Claudia] Univ Ulm, Dept Child & Adolescent Psychiat & Psychotherapy, Ulm, Germany.
RP Thome, J (reprint author), Swansea Univ, Sch Med, Inst Life Sci, Acad Unit Psychiat, Singleton Pk, Swansea SA2 8PP, W Glam, Wales.
EM j.thome@swan.ac.uk
RI Grassl, Julia/D-1047-2011
FU German Research Council [HU1536/1-1, HU1536/1-2]
FX The study was supported by the German Research Council (DFG HU1536/1-1,
HU1536/1-2).
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NR 45
TC 21
Z9 21
PU DR DIETRICH STEINKOPFF VERLAG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, 69121 HEIDELBERG, GERMANY
SN 0940-1334
J9 EUR ARCH PSY CLIN N
JI Eur. Arch. Psych. Clin. Neurosci.
PD APR
PY 2010
VL 260
IS 3
BP 249
EP 255
DI 10.1007/s00406-009-0066-5
PG 7
WC Clinical Neurology; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA 589ZA
UT WOS:000277191500010
PM 19784855
ER
PT J
AU Willemsen, MH
Fernandez, BA
Bacino, CA
Gerkes, E
de Brouwer, APM
Pfundt, R
Sikkema-Raddatz, B
Scherer, SW
Marshall, CR
Potocki, L
van Bokhoven, H
Kleefstra, T
AF Willemsen, Marjolein H.
Fernandez, Bridget A.
Bacino, Carlos A.
Gerkes, Erica
de Brouwer, Arjan P. M.
Pfundt, Rolph
Sikkema-Raddatz, Birgit
Scherer, Stephen W.
Marshall, Christian R.
Potocki, Lorraine
van Bokhoven, Hans
Kleefstra, Tjitske
TI Identification of ANKRD11 and ZNF778 as candidate genes for autism and
variable cognitive impairment in the novel 16q24.3 microdeletion
syndrome
SO EUROPEAN JOURNAL OF HUMAN GENETICS
LA English
DT Article
DE 16q24.3 microdeletion; ANKRD11; ZNF778; cognitive impairment; autism
ID LINKED MENTAL-RETARDATION; COMPARATIVE GENOMIC HYBRIDIZATION;
RUBINSTEIN-TAYBI-SYNDROME; STRUCTURAL VARIATION; CHARGE-SYNDROME; COPY
NUMBER; MUTATIONS; DUPLICATION; DELETION; REARRANGEMENTS
AB The clinical use of array comparative genomic hybridization in the evaluation of patients with multiple congenital anomalies and/or mental retardation has recently led to the discovery of a number of novel microdeletion and microduplication syndromes. We present four male patients with overlapping molecularly defined de novo microdeletions of 16q24.3. The clinical features observed in these patients include facial dysmorphisms comprising prominent forehead, large ears, smooth philtrum, pointed chin and wide mouth, variable cognitive impairment, autism spectrum disorder, structural anomalies of the brain, seizures and neonatal thrombocytopenia. Although deletions vary in size, the common region of overlap is only 90 kb and comprises two known genes, Ankyrin Repeat Domain 11 (ANKRD11) (MIM 611192) and Zinc Finger 778 (ZNF778), and is located approximately 10 kb distally to Cadherin 15 (CDH15) (MIM 114019). This region is not found as a copy number variation in controls. We propose that these patients represent a novel and distinctive microdeletion syndrome, characterized by autism spectrum disorder, variable cognitive impairment, facial dysmorphisms and brain abnormalities. We suggest that haploinsufficiency of ANKRD11 and/or ZNF778 contribute to this phenotype and speculate that further investigation of non-deletion patients who have features suggestive of this 16q24.3 microdeletion syndrome might uncover other mutations in one or both of these genes. European Journal of Human Genetics (2010) 18, 429-435; doi:10.1038/ejhg.2009.192; published online 18 November 2009
C1 [Willemsen, Marjolein H.; de Brouwer, Arjan P. M.; Pfundt, Rolph; van Bokhoven, Hans; Kleefstra, Tjitske] Radboud Univ Nijmegen, Med Ctr, Dept Human Genet, NL-6500 HB Nijmegen, Netherlands.
[Fernandez, Bridget A.] Mem Univ Newfoundland, Disciplines Genet & Med, St John, NF, Canada.
[Fernandez, Bridget A.] Eastern Hlth, Prov Med Genet Program, St John, NF, Canada.
[Bacino, Carlos A.; Potocki, Lorraine] Texas Childrens Hosp, Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA.
[Gerkes, Erica; Sikkema-Raddatz, Birgit] Univ Groningen, Univ Med Ctr Groningen, Dept Genet, NL-9713 AV Groningen, Netherlands.
[Scherer, Stephen W.; Marshall, Christian R.] Univ Toronto, Toronto, ON, Canada.
[Scherer, Stephen W.; Marshall, Christian R.] Hosp Sick Children, Ctr Appl Genom, Toronto, ON M5G 1X8, Canada.
RP Willemsen, MH (reprint author), Radboud Univ Nijmegen, Med Ctr, Dept Human Genet 849, POB 9101, NL-6500 HB Nijmegen, Netherlands.
EM m.willemsen@antrg.umcn.nl
RI van Bokhoven, Hans/D-8764-2012; Howe, Jennifer/I-9013-2012; Scherer,
Stephen /B-3785-2013; Willemsen, Marjolein/G-9491-2013; Kleefstra,
Tjitske/G-2619-2012
OI Scherer, Stephen /0000-0002-8326-1999;
FU Consortium VG Oost-Nederland; Genome Canada/Ontario Genomics Institute;
SickKids Foundation; National Alliance for Research on Schizophrenia and
Depression (NARSAD)
FX We thank the parents of patients who participated in this study. This
work was supported by grants from the Consortium VG Oost-Nederland (to
TK and MHW) and the Genome Canada/Ontario Genomics Institute (to SWS and
BF). CRM is supported by the SickKids Foundation and the National
Alliance for Research on Schizophrenia and Depression (NARSAD). SWS
holds the GlaxoSmithKline-CIHR Pathfinder Chair in Genetics and Genomics
at the University of Toronto and Hospital for Sick Children. Patient
consent was obtained from the patient's parents for publishing patient
pictures in Figure 1. We also thank Dr Zhinshuo Ou and the Kleberg
Cytogenetics Laboratory at Baylor College of Medicine.
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NR 44
TC 30
Z9 30
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1018-4813
J9 EUR J HUM GENET
JI Eur. J. Hum. Genet.
PD APR
PY 2010
VL 18
IS 4
BP 429
EP 435
DI 10.1038/ejhg.2009.192
PG 7
WC Biochemistry & Molecular Biology; Genetics & Heredity
SC Biochemistry & Molecular Biology; Genetics & Heredity
GA 571CF
UT WOS:000275726900010
PM 19920853
ER
PT J
AU Benony, H
AF Benony, Herve
TI Infantile sexuality and attachment relations. Notes on the revision of
metapsychology proposed by Laplanche
SO EVOLUTION PSYCHIATRIQUE
LA French
DT Article
DE Infant; Attachment relations; Infantile sexuality; Metapsychology;
Psychic birth; Earliest interactions; Inter-subjectivity; Theorical
study; Laplanche J; Psychoanalytic therapy; Clinical case; Transfert
ID AUTISM
AB The idea of a unified model of mental life makes it necessary to take account of the role of the recent ideas issuing from attachment theory while simultaneously reconsidering Freudian metapsychology. The revisited and then revised basis of metapsychology proposed by Laplanche (1970, 1993, 2007) considers that interhuman adult-infant communication emerges from an instinctual genetic basis but that, from the very beginning, this communication is compromised by the adult's infantile unconscious. In other words, this situation of adult-infant communication or Fundamental Anthropological Situation reignites the parent's unconscious conflictuality - in his relations to his own parents and points him back towards his own history as a child. In this way, unconscious adult sexuality infuses the care bestowed by the other involved in the attachment and puts the child's psyche "to work", with the child thus attempting to translate the enigma of this message and forming the basis for his or her own unconscious. A case study of child psychoanalysis is presented to illustrate this model. (C) 2010 Elsevier Masson SAS. All rights reserved.
C1 [Benony, Herve] Univ Bourgogne, LPPM EA 5542, Pole AAFE, F-21065 Dijon, France.
[Benony, Herve] Hop Jour Les Cigognes, F-21300 Chenove, France.
RP Benony, H (reprint author), Univ Bourgogne, LPPM EA 5542, Pole AAFE, BP 26513, F-21065 Dijon, France.
EM herve.benony@u-bourgogne.fr
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NR 38
TC 1
Z9 1
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI PARIS
PA 23 RUE LINOIS, 75724 PARIS, FRANCE
SN 0014-3855
J9 EVOL PSYCHIATR
JI Evol. Psychiatr.
PD APR-JUN
PY 2010
VL 75
IS 2
BP 287
EP 301
DI 10.1016/j.evopsy.2010.04.007
PG 15
WC Psychiatry
SC Psychiatry
GA 620TA
UT WOS:000279521600008
ER
PT J
AU Nevels, RM
Dehon, EE
Alexander, K
Gontkovsky, ST
AF Nevels, Robert M.
Dehon, Erin E.
Alexander, Katrina
Gontkovsky, Samuel T.
TI Psychopharmacology of Aggression in Children and Adolescents With
Primary Neuropsychiatric Disorders: A Review of Current and Potentially
Promising Treatment Options
SO EXPERIMENTAL AND CLINICAL PSYCHOPHARMACOLOGY
LA English
DT Review
DE pediatric psychopharmacology; aggression in children and adolescents;
disorders with comorbid aggression; treatment
ID ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; DEFICIT HYPERACTIVITY
DISORDER; DISRUPTIVE BEHAVIOR DISORDERS; AUTISM SPECTRUM DISORDERS;
CYCLING BIPOLAR DISORDER; PLACEBO-CONTROLLED TRIAL; FRAGILE-X SYNDROME;
DOUBLE-BLIND; OPEN-LABEL; DIVALPROEX SODIUM
AB Research examining the role of pharmacological therapy in the treatment of children and adolescents with clinical disorders is growing. Clinical disorders that present with comorbid aggression can add a challenge to treatment. Child and adolescent neuropsychiatric disorders associated with aggression include attention-deficit hyperactivity disorder, various mood disorders and in particular bipolar disorders/pediatric mania, schizophrenia, mental retardation, oppositional defiant disorder, conduct disorder, and autism spectrum disorders. This review describes the psychopharmacy to treat these disorders and the aggression that often appears comorbidly. Existing literature regarding the efficacy and safety of psychotropics for youth with neuropsychiatric disorders also is discussed. In addition, general guidelines for psychopharmacy of aggression in children and adolescents are presented. Studies reviewed in this article provide evidence for the use of psychostimulants, alpha-2 agonists, beta blockers, lithium, anticonvulsant mood-stabilizers, atypical antipsychotics, traditional antipsychotics, and selective serotonin reuptake inhibitors in treating pediatric aggression with the choice of medication dependent on symptomology. Despite increased support for pediatric psychotropic use, there is a need for more long-term safety and efficacy studies of existing medications and newer, safer, and more effective agents with fewer side effects for the pharmacological treatment of all childhood disorders in which aggression is prominent.
C1 [Gontkovsky, Samuel T.] Methodist Rehabil Ctr, Ctr Neurosci & Neurol Recovery, Jackson, MS 39216 USA.
[Nevels, Robert M.; Dehon, Erin E.; Alexander, Katrina] Jackson State Univ, Dept Psychol, Jackson, MS USA.
RP Gontkovsky, ST (reprint author), Methodist Rehabil Ctr, Ctr Neurosci & Neurol Recovery, 1350 E Woodrow Wilson, Jackson, MS 39216 USA.
EM sgontkovsky@hotmail.com
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YAN J, 2009, PSYCHIAT NEWS 0515, V44, P20
NR 93
TC 19
Z9 19
PU AMER PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA
SN 1064-1297
J9 EXP CLIN PSYCHOPHARM
JI Exp. Clin. Psychopharmacol.
PD APR
PY 2010
VL 18
IS 2
BP 184
EP 201
DI 10.1037/a0018059
PG 18
WC Psychology, Biological; Psychology, Clinical; Pharmacology & Pharmacy;
Psychiatry
SC Psychology; Pharmacology & Pharmacy; Psychiatry
GA 582CU
UT WOS:000276573900009
PM 20384430
ER
PT J
AU Zalla, T
Labruyere, N
Clement, A
Georgieff, N
AF Zalla, Tiziana
Labruyere, Nelly
Clement, Amelie
Georgieff, Nicolas
TI Predicting ensuing actions in children and adolescents with autism
spectrum disorders
SO EXPERIMENTAL BRAIN RESEARCH
LA English
DT Article
DE Scripts; Action understanding; Mirror neurons; Frontal cortex
ID MIRROR NEURON SYSTEM; LATERAL PREFRONTAL CORTEX; FRONTAL-LOBE DAMAGE;
ACTION RECOGNITION; ACTION REPRESENTATION; MOTOR SIMULATION; SOCIAL
COGNITION; BROCAS AREA; IMITATION; INTENTIONS
AB This study investigated the ability to predict others' action in a group of children and adolescents with autism spectrum disorders (ASD) (n = 18). Their performance was compared with a group of children with mental retardation (n = 13) and a group of children with typical development (n = 19). Participants were presented with short incomplete videotaped movies showing an actor executing familiar and non-familiar actions. When asked to predict the outcome, participants with ASD produced fewer correct responses and their performance did not improve for familiar actions, as compared to both comparison groups. In addition, they committed a greater number of errors of temporal inversion. These results provide new evidence that an impaired means-end analysis process, leading to a diminished sensitivity to the sequence structure of goal-directed actions, would disrupt the ability to understand and predict others' actions. The comprehension of abnormalities in event knowledge provides a better insight of some of the problems that individuals with ASD encounter in spontaneously understanding real-life social situations.
C1 [Zalla, Tiziana] Ecole Normale Super, CNRS, Inst Jean Nicod, F-75005 Paris, France.
[Labruyere, Nelly; Georgieff, Nicolas] Inst Cognit Sci, Bron, France.
[Labruyere, Nelly; Georgieff, Nicolas] Ctr Hosp Vinatier, ITTAC, Bron, France.
[Clement, Amelie] Hosp Civil Lyon, Lyon, France.
RP Zalla, T (reprint author), Ecole Normale Super, CNRS, Inst Jean Nicod, 29 Rue Ulm, F-75005 Paris, France.
EM tiziana.zalla@ens.fr
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NR 74
TC 17
Z9 17
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0014-4819
J9 EXP BRAIN RES
JI Exp. Brain Res.
PD APR
PY 2010
VL 201
IS 4
BP 809
EP 819
DI 10.1007/s00221-009-2096-7
PG 11
WC Neurosciences
SC Neurosciences & Neurology
GA 569VT
UT WOS:000275631300018
PM 19956934
ER
PT J
AU Brown, A
Chow, D
Murakami, S
Goh, W
Perreira, A
Kwee, S
Sil, P
LeRoy, M
AF Brown, Amy
Chow, Dominic
Murakami, Satona
Goh, William
Perreira, Aimee
Kwee, Sandi
Sil, Payel
LeRoy, Majdouline
TI Possible gastrointestinal symptoms in a subset of children with autism
SO EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY
LA English
DT Editorial Material
ID CELIAC-DISEASE; TURNER-SYNDROME; RETT-SYNDROME; INCREASED PREVALENCE;
CONSTIPATION; DISORDERS; TRANSGLUTAMINASE; RECOMMENDATIONS; ANTIBODIES;
DIAGNOSIS
C1 [Brown, Amy] Univ Hawaii, Dept Complementary & Alternat Med, John A Burns Sch Med, Honolulu, HI 96813 USA.
[Chow, Dominic] Univ Hawaii, Dept Pediat, Honolulu, HI 96813 USA.
[Chow, Dominic; Kwee, Sandi] Univ Hawaii, Dept Med, Honolulu, HI 96813 USA.
[Murakami, Satona] Nagoya City Univ, Grad Sch Med Sci, Dept Orthoped Surg, Nagoya, Aichi, Japan.
[Goh, William] Univ Hawaii, Dept Obstet & Gynecol, Honolulu, HI 96813 USA.
[LeRoy, Majdouline] Univ Hawaii, Dept Mol Biosci & Bioengn, Honolulu, HI 96816 USA.
RP Brown, A (reprint author), Univ Hawaii, Dept Complementary & Alternat Med, John A Burns Sch Med, 651 Ilalo St,MEB 223, Honolulu, HI 96813 USA.
EM amybrown@hawaii.edu
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NR 26
TC 2
Z9 3
PU EXPERT REVIEWS
PI LONDON
PA UNITEC HOUSE, 3RD FL, 2 ALBERT PLACE, FINCHLEY CENTRAL, LONDON N3 1QB,
ENGLAND
SN 1747-4124
J9 EXPERT REV GASTROENT
JI Expert Rev. Gastroenterol. Hepatol.
PD APR
PY 2010
VL 4
IS 2
BP 125
EP 127
DI 10.1586/EGH.10.17
PG 3
WC Gastroenterology & Hepatology
SC Gastroenterology & Hepatology
GA 860XS
UT WOS:000297982300001
PM 20350258
ER
PT J
AU Lopalco, PL
Johansen, K
Ciancio, B
Gomes, HDC
Kramarz, P
Giesecke, J
AF Lopalco, Pier Luigi
Johansen, Kari
Ciancio, Bruno
Gomes, Helena De Carvalho
Kramarz, Piotr
Giesecke, Johan
TI Monitoring and assessing vaccine safety: a European perspective
SO EXPERT REVIEW OF VACCINES
LA English
DT Article
DE adverse effects; European Union; immunization program; vaccination;
vaccine safety
ID HEPATITIS-B VACCINATION; MULTIPLE-SCLEROSIS; CAUSAL ASSOCIATION;
IMMUNIZATION; CAMPAIGN; AUTISM; RISK; MMR
AB The success of vaccination programs is an uncontroversial reality in Europe as well as worldwide. On the other hand, the perceived risk of adverse events in the general public is the most important threat for implementing successful vaccination programs in Europe. For this reason, monitoring and assessing vaccine safety is a priority for public health. Vaccine safety is assessed both before and after vaccine authorization. In postmarketing settings, different activities related to vaccine safety usually involve several different stakeholders. In 2005, a new EU agency, the European Centre for Disease Prevention and Control, was established with the aim to strengthen Europe's defences against infectious diseases. Implementing stable links between different stakeholders and defining clear roles in the EU is paramount in order to provide optimal and transparent information on adverse reactions following immunization, with the final goal of increasing compliance to safe and effective vaccination programs.
C1 [Lopalco, Pier Luigi; Johansen, Kari; Ciancio, Bruno; Gomes, Helena De Carvalho; Kramarz, Piotr; Giesecke, Johan] European Ctr Dis Prevent & Control, Sci Advice Unit, SE-17183 Stockholm, Sweden.
RP Lopalco, PL (reprint author), European Ctr Dis Prevent & Control, Sci Advice Unit, SE-17183 Stockholm, Sweden.
EM pierluigi.lopalco@ecdc.europa.eu
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*EUR MED AG, CHMP REC COR RISK MA
*EUR MED AG, AUTH SUP MED PROD
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World Health Organization, ADV EV FOLL IMM AEFI
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Zanonia G, 2009, VACCINE, V27, P3376, DOI 10.1016/j.vaccine.2009.01.059
NR 23
TC 7
Z9 7
PU EXPERT REVIEWS
PI LONDON
PA UNITEC HOUSE, 3RD FL, 2 ALBERT PLACE, FINCHLEY CENTRAL, LONDON N3 1QB,
ENGLAND
SN 1476-0584
J9 EXPERT REV VACCINES
JI Expert Rev. Vaccines
PD APR
PY 2010
VL 9
IS 4
BP 371
EP 380
DI 10.1586/ERV.10.20
PG 10
WC Immunology
SC Immunology
GA 590GV
UT WOS:000277214200011
PM 20370548
ER
PT J
AU Shamberger, RJ
AF Shamberger, Raymond Joseph
TI AUTISM LINKED TO NUTRITION
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Shamberger, Raymond Joseph] King James Med Lab, Cleveland, OH USA.
NR 0
TC 0
Z9 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2010
VL 24
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V28IW
UT WOS:000208675500404
ER
PT J
AU Vidal, J
Bonnet-Brilhault, F
Barthelemy, C
Bruneau, N
AF Vidal, J.
Bonnet-Brilhault, F.
Barthelemy, C.
Bruneau, N.
TI Electrophysiological evidence of atypical auditory-visual interactions
in children with autism
SO FUNDAMENTAL & CLINICAL PHARMACOLOGY
LA English
DT Meeting Abstract
C1 [Vidal, J.] Hosp Sick Children, Toronto, ON M5G 1X8, Canada.
[Bonnet-Brilhault, F.; Barthelemy, C.; Bruneau, N.] CNRS, INSERM, UMR U ERL 3106, F-75700 Paris, France.
[Bonnet-Brilhault, F.; Barthelemy, C.; Bruneau, N.] Univ Tours, F-37041 Tours, France.
[Bonnet-Brilhault, F.; Barthelemy, C.] CHRU Tours, Tours, France.
NR 0
TC 0
Z9 0
PU WILEY-BLACKWELL PUBLISHING, INC
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0767-3981
J9 FUND CLIN PHARMACOL
JI Fundam. Clin. Pharmacol.
PD APR
PY 2010
VL 24
SU 1
MA 6
BP 2
EP 2
PG 1
WC Pharmacology & Pharmacy
SC Pharmacology & Pharmacy
GA 576PH
UT WOS:000276156800007
ER
PT J
AU Darbari, A
Rawal, N
Jhaveri, PN
Jhaveri, PB
AF Darbari, Anil
Rawal, Nidhi
Jhaveri, Punit N.
Jhaveri, Pooja B.
TI Children With Autism and Feeding Problems Have Significant Endoscopic
Findings
SO GASTROINTESTINAL ENDOSCOPY
LA English
DT Meeting Abstract
CT Digestive Disease Week/111th Annual Meeting of the
American-Gastroenterological-Association
CY MAY 01-06, 2010
CL New Orleans, LA
SP Amer Gastroenterol Assoc
NR 0
TC 0
Z9 0
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0016-5107
J9 GASTROINTEST ENDOSC
JI Gastrointest. Endosc.
PD APR
PY 2010
VL 71
IS 5
BP AB257
EP AB257
PG 1
WC Gastroenterology & Hepatology
SC Gastroenterology & Hepatology
GA 583WJ
UT WOS:000276710401100
ER
PT J
AU Clarke, GM
Cardon, LR
AF Clarke, Geraldine M.
Cardon, Lon R.
TI Aspects of Observing and Claiming Allele Flips in Association Studies
SO GENETIC EPIDEMIOLOGY
LA English
DT Article
DE SNPs; linkage disequilibrium; association; power; genetic effect; type I
error rate
ID SEROTONIN TRANSPORTER GENE; LINKAGE DISEQUILIBRIUM; POPULATION
STRATIFICATION; PARKINSONS-DISEASE; 6P22.3 GENE; AUTISM; POLYMORPHISM;
PROMOTER; GENOME; LOCI
AB Significant allele flipping, where associations for the same disease occur at opposite alleles of the same bi-allelic locus, is increasing. But when is a significant allele flip genuine? We address the statistical issues of claiming and observing genuine allele flips in actual samples. We show that unless an allele flip is genuine, the probability of observing a significant allele flip in samples ascertained similarly from a common population is negligible. We derive expressions for the expected values of commonly used measures of association, which confirm previous findings that the underlying mechanism of a genuine allele flip is variation in the haplotype frequencies and show further how this variation interacts with variation in the genetic effects to impact allele flipping. We show that for association testing at proxy SNPs, common in genome-wide association studies, variation in haplotype frequencies must coincide with a reversal in the sign of linkage disequilibrium (LD) to trigger genuine allele flips. Using HapMap data and r, rather than r(2), to highlight previously unobserved effects, we show that unless genetic effects are large, variation in LD is unlikely to cause genuine allele flips in samples drawn from the same population. However, as populations diverge, it is an increasingly viable cause of a genuine allele flip for sufficiently large genetic effect and/or sample sizes. We conclude that evidence of variation in local patterns of LD, ancestral composition of study samples, and environmental exposures between study populations can provide compelling practical evidence in defense of a genuine allele flip. Genet. Epidemiol. 34:266-274, 2010. (C) 2009 Wiley-Liss, Inc.
C1 [Clarke, Geraldine M.] Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford OX3 7BN, England.
[Cardon, Lon R.] GlaxoSmithKline Inc, Philadelphia, PA USA.
RP Clarke, GM (reprint author), Univ Oxford, Wellcome Trust Ctr Human Genet, Roosevelt Dr, Oxford OX3 7BN, England.
EM gclarke@well.ox.ac.uk
FU Wellcome Trust
FX Contract grant sponsor: Wellcome Trust.
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NR 34
TC 20
Z9 20
PU WILEY-LISS
PI HOBOKEN
PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 0741-0395
J9 GENET EPIDEMIOL
JI Genet. Epidemiol.
PD APR
PY 2010
VL 34
IS 3
BP 266
EP 274
DI 10.1002/gepi.20458
PG 9
WC Genetics & Heredity; Public, Environmental & Occupational Health
SC Genetics & Heredity; Public, Environmental & Occupational Health
GA 580KW
UT WOS:000276448100009
PM 20013941
ER
PT J
AU Hyde, KL
Samson, F
Evans, AC
Mottron, L
AF Hyde, Krista L.
Samson, Fabienne
Evans, Alan C.
Mottron, Laurent
TI Neuroanatomical Differences in Brain Areas Implicated in Perceptual and
Other Core Features of Autism Revealed by Cortical Thickness Analysis
and Voxel-Based Morphometry
SO HUMAN BRAIN MAPPING
LA English
DT Article
DE autism; brain; MRI; enhanced perceptual functioning model; cortical
thickness; voxel-based-morphometry
ID PERVASIVE DEVELOPMENTAL DISORDERS; OBSESSIVE-COMPULSIVE DISORDER;
AUTOMATED 3-D EXTRACTION; HIGH-FUNCTIONING AUTISM; SPECTRUM DISORDER;
HEAD CIRCUMFERENCE; ASPERGERS-SYNDROME; PLANUM TEMPORALE; SOCIAL
COGNITION; MATTER VOLUME
AB Autism spectrum disorder is a complex neurodevelopmental variant thought to affect 1 in 166 [Fombonne (2003): J Autism Dev Disord 33:365-382]. Individuals with autism demonstrate atypical social interaction, communication, and repetitive behaviors, but can also present enhanced abilities, particularly in auditory and visual perception and nonverbal reasoning. Structural brain differences have been reported in autism, in terms of increased total brain volume (particularly in young children with autism), and regional gray/white matter differences in both adults and children with autism, but the reports are inconsistent [Amaral et al. (2008): Trends Neurosci 31:137-145]. These inconsistencies may be due to differences in diagnostic/inclusion criteria, and age and Intelligence Quotient of participants. Here, for the first time, we used two complementary magnetic resonance imaging techniques, cortical thickness analyses, and voxel-based morphometry (VBM), to investigate the neuroanatomical differences between a homogenous group of young adults with autism of average intelligence but delayed or atypical language development (often referred to as "high-functioning autism"), relative to a closely matched group of typically developing controls. The cortical thickness and VBM techniques both revealed regional structural brain differences (mostly in terms of gray matter increases) in brain areas implicated in social cognition, communication, and repetitive behaviors, and thus in each of the core atypical features of autism. Gray matter increases were also found in auditory and visual primary and associative perceptual areas. We interpret these results as the first structural brain correlates of atypical auditory and visual perception in autism, in support of the enhanced perceptual functioning model [Mottron et al. (2006): J Autism Dev Disord 36:27-43]. Hum Brain Mapp 31:556-566, 2010. (C) 2009 Wiley-Liss, Inc.
C1 [Hyde, Krista L.; Evans, Alan C.] McGill Univ, Montreal Neurol Inst, McConnell Brain Imaging Ctr, Montreal, PQ H3A 2B4, Canada.
[Samson, Fabienne; Mottron, Laurent] Univ Montreal, Hop Riviere Prairies, Ctr Excellence Troubles Envahissants Dev, Montreal, PQ H1E 1A4, Canada.
RP Hyde, KL (reprint author), McGill Univ, Montreal Neurol Inst, McConnell Brain Imaging Ctr, 3801 Univ St, Montreal, PQ H3A 2B4, Canada.
EM krista.hyde@mail.mcgill.ca
FU Canadian Institutes of Health Research
FX Contract grant sponsor: Canadian Institutes of Health Research.
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NR 77
TC 86
Z9 91
PU WILEY-LISS
PI HOBOKEN
PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 1065-9471
J9 HUM BRAIN MAPP
JI Hum. Brain Mapp.
PD APR
PY 2010
VL 31
IS 4
BP 556
EP 566
DI 10.1002/hbm.20887
PG 11
WC Neurosciences; Neuroimaging; Radiology, Nuclear Medicine & Medical
Imaging
SC Neurosciences & Neurology; Radiology, Nuclear Medicine & Medical Imaging
GA 581PZ
UT WOS:000276537800006
PM 19790171
ER
PT J
AU Castermans, D
Volders, K
Crepel, A
Backx, L
De Vos, R
Freson, K
Meulemans, S
Vermeesch, JR
Schrander-Stumpel, CTRM
De Rijk, P
Del-Favero, J
Van Geet, C
Van De Ven, WJM
Steyaert, JG
Devriendt, K
Creemers, JWM
AF Castermans, Dries
Volders, Karolien
Crepel, An
Backx, Liesbeth
De Vos, Rita
Freson, Kathleen
Meulemans, Sandra
Vermeesch, Joris R.
Schrander-Stumpel, Connie T. R. M.
De Rijk, Peter
Del-Favero, Jurgen
Van Geet, Chris
Van De Ven, Wim J. M.
Steyaert, Jean G.
Devriendt, Koen
Creemers, John W. M.
TI SCAMP5, NBEA and AMISYN: three candidate genes for autism involved in
secretion of large dense-core vesicles
SO HUMAN MOLECULAR GENETICS
LA English
DT Article
ID 15Q24 MICRODELETION SYNDROME; MENTAL-RETARDATION; SPECTRUM DISORDER;
NEUROBEACHIN GENE; NEUROLIGIN GENES; MEMBRANE-FUSION; MUTATIONS;
EXOCYTOSIS; IDENTIFICATION; ASSOCIATION
AB Autism is a neurodevelopmental disorder characterized by impaired social reciprocity, impaired communication and stereotypical behaviors. Despite strong evidence for a genetic basis, few susceptibility genes have been identified. Here, we describe the positional cloning of SCAMP5, CLIC4 and PPCDC as candidate genes for autism, starting from a person with idiopathic, sporadic autism carrying a de novo chromosomal translocation. One of these genes, SCAMP5 is silenced on the derivative chromosome, and encodes a brain-enriched protein involved in membrane trafficking, similar to the previously identified candidate genes NBEA and AMISYN. Gene silencing of Nbea, Amisyn and Scamp5 in mouse beta-TC3 cells resulted in a 2-fold increase in stimulated secretion of large dense-core vesicles (LDCVs), while overexpression suppressed secretion. Moreover, ultrastructural analysis of blood platelets from the patients with haploinsufficieny of one of the three candidate genes, showed morphological abnormalities of dense-core granules, which closely resemble LDCVs. Taken together, this study shows that in three independent patients with autism three different negative regulators of LDCV secretion are affected, respectively, suggesting that in at least a subgroup of patients the regulation of neuronal vesicle trafficking may be involved in the pathogenesis of autism.
C1 [Castermans, Dries; Volders, Karolien; Meulemans, Sandra; Creemers, John W. M.] Catholic Univ Louvain, Dept Human Genet, Biochem Neuroendocrinol Lab, B-3000 Louvain, Belgium.
[Crepel, An; Backx, Liesbeth; Vermeesch, Joris R.; Steyaert, Jean G.; Devriendt, Koen] Catholic Univ Louvain, Ctr Human Genet, Div Clin Genet, B-3000 Louvain, Belgium.
[De Vos, Rita] Catholic Univ Louvain, Dept Med Diagnost Sci, Morphol & Mol Pathol Sect, B-3000 Louvain, Belgium.
[Freson, Kathleen; Van Geet, Chris] Catholic Univ Louvain, Dept Mol & Cellular Med, Ctr Mol & Vasc Biol, B-3000 Louvain, Belgium.
[Van De Ven, Wim J. M.] Catholic Univ Louvain, Dept Human Genet, Mol Oncol Lab, B-3000 Louvain, Belgium.
[Van Geet, Chris] Catholic Univ Louvain, Dept Pediat, B-3000 Louvain, Belgium.
[Steyaert, Jean G.] Catholic Univ Louvain, Dept Child Psychiat, B-3000 Louvain, Belgium.
[Schrander-Stumpel, Connie T. R. M.] Univ Maastricht, Clin Genet Ctr, NL-6201 BL Maastricht, Netherlands.
[De Rijk, Peter; Del-Favero, Jurgen; Steyaert, Jean G.] VIB, Dept Mol Genet, Appl Mol Genom Grp, Louvain, Belgium.
[De Rijk, Peter; Del-Favero, Jurgen] Univ Antwerp, B-2610 Antwerp, Belgium.
RP Creemers, JWM (reprint author), Catholic Univ Louvain, Dept Human Genet, Biochem Neuroendocrinol Lab, Herestr 49, B-3000 Louvain, Belgium.
EM john.creemers@med.kuleuven.be
RI Steyaert, Jean/B-5326-2015
OI Steyaert, Jean/0000-0003-2512-4694
FU Cure Autism Now; Interuniversity Attraction Poles Program-Belgian
Science Policy [IUAP 5/25]; 'Geconcerteerde Onderzoeksacties'
[GOA/2006/12, GOA/2008/16]; 'Fonds voor Wetenschappelijk Onderzoek
Vlaanderen (FWO)' [G0264.04, G.0124.02]; 'interdisciplinaire
onderzoeksprogramma (IDO)'; Instituut voor de aanmoediging van Innovatie
door wetenschap en technologie in Vlaanderen (IWT); Clinical Research
Fund U.Z. Leuven
FX This work was supported by grants from Cure Autism Now, the
Interuniversity Attraction Poles Program-Belgian Science Policy (IUAP
5/25), 'Geconcerteerde Onderzoeksacties' GOA/2006/12 and GOA/2008/16,
'Fonds voor Wetenschappelijk Onderzoek Vlaanderen (FWO)' G0264.04 and
G.0124.02 and 'interdisciplinaire onderzoeksprogramma (IDO)'. K. V. is
supported by a grant from the Instituut voor de aanmoediging van
Innovatie door wetenschap en technologie in Vlaanderen (IWT). J. S. is
supported by a grant of the Clinical Research Fund U.Z. Leuven. K.D. is
a Senior Clinical Investigator of FWO, K. F. is postdoctoral fellow of
FWO, A.C. is PhD fellow of FWO.
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NR 73
TC 28
Z9 28
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0964-6906
J9 HUM MOL GENET
JI Hum. Mol. Genet.
PD APR
PY 2010
VL 19
IS 7
BP 1368
EP 1378
DI 10.1093/hmg/ddq013
PG 11
WC Biochemistry & Molecular Biology; Genetics & Heredity
SC Biochemistry & Molecular Biology; Genetics & Heredity
GA 572HK
UT WOS:000275818500019
PM 20071347
ER
PT J
AU Riedmann, EM
AF Riedmann, Eva M.
TI Lancet retracts controversial Autism Study
SO HUMAN VACCINES
LA English
DT News Item
NR 0
TC 0
Z9 0
PU LANDES BIOSCIENCE
PI AUSTIN
PA 1806 RIO GRANDE ST, AUSTIN, TX 78702 USA
SN 1554-8600
J9 HUM VACCINES
JI Hum. Vaccines
PD APR
PY 2010
VL 6
IS 4
BP 286
EP 286
PG 1
WC Biotechnology & Applied Microbiology; Immunology
SC Biotechnology & Applied Microbiology; Immunology
GA 652GH
UT WOS:000281990800001
ER
PT J
AU Gorczowski, K
Styner, M
Jeong, JY
Marron, JS
Piven, J
Hazlett, HC
Pizer, SM
Gerig, G
AF Gorczowski, Kevin
Styner, Martin
Jeong, Ja Yeon
Marron, J. S.
Piven, Joseph
Hazlett, Heather Cody
Pizer, Stephen M.
Gerig, Guido
TI Multi-Object Analysis of Volume, Pose, and Shape Using Statistical
Discrimination
SO IEEE TRANSACTIONS ON PATTERN ANALYSIS AND MACHINE INTELLIGENCE
LA English
DT Article
DE Shape; size and shape; shape analysis
ID DEFORMABLE M-REPS; CAUDATE-NUCLEUS; SEGMENTATION; SCHIZOPHRENIA; AUTISM;
MODELS; LEVEL; MRI; HIPPOCAMPUS; DISORDER
AB One goal of statistical shape analysis is the discrimination between two populations of objects. Whereas traditional shape analysis was mostly concerned with single objects, analysis of multi-object complexes presents new challenges related to alignment and pose. In this paper, we present a methodology for discriminant analysis of multiple objects represented by sampled medial manifolds. Non-euclidean metrics that describe geodesic distances between sets of sampled representations are used for alignment and discrimination. Our choice of discriminant method is the distance-weighted discriminant because of its generalization ability in high-dimensional, low sample size settings. Using an unbiased, soft discrimination score, we associate a statistical hypothesis test with the discrimination results. We explore the effectiveness of different choices of features as input to the discriminant analysis, using measures like volume, pose, shape, and the combination of pose and shape. Our method is applied to a longitudinal pediatric autism study with 10 subcortical brain structures in a population of 70 subjects. It is shown that the choices of type of global alignment and of intrinsic versus extrinsic shape features, the latter being sensitive to relative pose, are crucial factors for group discrimination and also for explaining the nature of shape change in terms of the application domain.
C1 [Gorczowski, Kevin; Styner, Martin; Jeong, Ja Yeon; Pizer, Stephen M.] Univ N Carolina, Dept Comp Sci, Chapel Hill, NC 27599 USA.
[Styner, Martin; Piven, Joseph; Hazlett, Heather Cody] Univ N Carolina, Dept Psychiat, Chapel Hill, NC 27599 USA.
[Marron, J. S.] Univ N Carolina, Dept Stat & Operat Res, Chapel Hill, NC 27599 USA.
[Gerig, Guido] Univ Utah, Sci Comp & Imaging Inst SCI, Salt Lake City, UT 84112 USA.
RP Gorczowski, K (reprint author), Univ N Carolina, Dept Comp Sci, CB 3175, Chapel Hill, NC 27599 USA.
EM kgorcz@unc.edu; styner@cs.unc.edu; jjeong@email.unc.edu;
marron@email.unc.edu; jpiven@med.unc.edu; hcody@med.unc.edu;
smp@cs.unc.edu; gerig@sci.utah.edu
FU NIH NIBIB [P01 EB002779]; NIH Conte Center [MH064065]; UNC
Neurodevelopmental Research Core NDRC; NIH [RO1 MH61696]; NIMH [MH64580]
FX This research is supported by the NIH NIBIB grant P01 EB002779, the NIH
Conte Center MH064065, and the UNC Neurodevelopmental Research Core
NDRC. The MRI images of infants and expert manual segmentations are
funded by NIH RO1 MH61696 and NIMH MH64580.
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TC 25
Z9 25
PU IEEE COMPUTER SOC
PI LOS ALAMITOS
PA 10662 LOS VAQUEROS CIRCLE, PO BOX 3014, LOS ALAMITOS, CA 90720-1314 USA
SN 0162-8828
J9 IEEE T PATTERN ANAL
JI IEEE Trans. Pattern Anal. Mach. Intell.
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PY 2010
VL 32
IS 4
BP 652
EP 661
DI 10.1109/TPAMI.2009.92
PG 10
WC Computer Science, Artificial Intelligence; Engineering, Electrical &
Electronic
SC Computer Science; Engineering
GA 555XA
UT WOS:000274548800007
PM 20224121
ER
PT J
AU Coakley, T
AF Coakley, Tom
TI State Guidance Documents for Young Children With Autism Spectrum
Disorders Content and Comparison
SO INFANTS AND YOUNG CHILDREN
LA English
DT Article
DE autism; ASD; IDEA Part C; IDEA Section 619; state systems
AB The dramatic increase in the identification of young children with autism spectrum disorders (ASD) beginning in the 1980s presented many challenges to State Education Agencies responsible for Special Education for school aged children and State Part C Lead Agencies responsible for Early Intervention services for infants and toddlers under the IDEA. This expanding population was being identified at younger ages and required intensive treatment by qualified personnel, straining system capacity. As part of their efforts to provide evidence based, comprehensive, accessible, and effective services for these children, many states have developed guidance documents about ASD for their early childhood systems. A review and comparison of nine of these documents shows them to have many differences in focus and content, even though they have similar intent. Further inquiry is required to understand the impact of these documents have had in meeting the needs of young children with ASD.
C1 Housaton Community Coll, Bridgeport, CT 06604 USA.
RP Coakley, T (reprint author), Housaton Community Coll, 900 Lafayette Blvd, Bridgeport, CT 06604 USA.
EM tc.unlimited@ymail.com
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NR 15
TC 2
Z9 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0896-3746
J9 INFANT YOUNG CHILD
JI Infants Young Child.
PD APR-JUN
PY 2010
VL 23
IS 2
BP 145
EP 164
DI 10.1097/IYC.0b013e3181d5c3b9
PG 20
WC Education, Special; Psychology, Developmental; Rehabilitation
SC Education & Educational Research; Psychology; Rehabilitation
GA 572GV
UT WOS:000275816700007
ER
PT J
AU Fallet, C
AF Fallet, C.
TI Influence of paternal age
SO JOURNAL DE GYNECOLOGIE OBSTETRIQUE ET BIOLOGIE DE LA REPRODUCTION
LA French
DT Article
DE Paternal; Age; Toxic
ID PREGNANCY; RATES
AB Father's age increase miscarriage, malformation, risk of autism, schizophrenia, and bipolar troubles in children. (C) 2010 Elsevier Masson SAS. All rights reserved.
EM christinefallet@hotmail.com
CR Belloc S, 2008, REPROD BIOMED ONLINE, V17, P392
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MACGRATH J, 2009, ANN EPIDEMI IN PRESS
Malaspina D, 2005, PSYCHIAT GENET, V15, P117, DOI 10.1097/00041444-200506000-00008
PERTHUS I, 2008, MALFORMATIONS FOETAL, P28
NR 6
TC 0
Z9 0
PU ELSEVIER MASSON
PI MILANO
PA VIA PALEOCAPA 7, 20121 MILANO, ITALY
SN 0368-2315
J9 J GYNECOL OBST BIO R
JI J. Gynecol. Obstet. Biol. Reprod.
PD APR
PY 2010
VL 39
SI 1
BP 36
EP 38
PG 3
WC Obstetrics & Gynecology
SC Obstetrics & Gynecology
GA 605EJ
UT WOS:000278330000012
ER
PT J
AU Hobson, RP
Garcia-Perez, RM
Lee, A
AF Hobson, R. Peter
Garcia-Perez, Rosa M.
Lee, Anthony
TI Person-Centred (Deictic) Expressions and Autism
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism; Deixis; Identification; Pointing; Communicative intent; Self
ID DEVELOPMENTAL LANGUAGE DELAY; JOINT ATTENTION; COMMUNICATION; CHILDREN;
IDENTIFICATION; PRONOUNS; ACQUISITION; IMITATION
AB We employed semi-structured tests to determine whether children with autism produce and comprehend deictic (person-centred) expressions such as 'this'/'that', 'here'/'there' and 'come'/'go', and whether they understand atypical non-verbal gestural deixis in the form of directed head-nods to indicate location. In Study 1, most participants spontaneously produced deictic terms, often in conjunction with pointing. Yet only among children with autism were there participants who referred to a location that was distal to themselves with the terms 'this' or 'here', or made atypical points with unusual precision, often lining-up with an eye. In Study 2, participants with autism were less accurate in responding to instructions involving contrastive deictic terms, and fewer responded accurately to indicative head nods.
C1 [Hobson, R. Peter; Garcia-Perez, Rosa M.; Lee, Anthony] Tavistock Clin, London NW3 5BA, England.
[Hobson, R. Peter] UCL, Inst Child Hlth, London, England.
[Garcia-Perez, Rosa M.] Ctr Music Therapy & Child Psychol, Madrid 28006, Spain.
RP Hobson, RP (reprint author), Tavistock Clin, 120 Belsize Lane, London NW3 5BA, England.
EM r.hobson@ucl.ac.uk
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NR 40
TC 8
Z9 8
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD APR
PY 2010
VL 40
IS 4
BP 403
EP 415
DI 10.1007/s10803-009-0882-5
PG 13
WC Psychology, Developmental
SC Psychology
GA 568UZ
UT WOS:000275550200001
PM 19888642
ER
PT J
AU Kenworthy, L
Case, L
Harms, MB
Martin, A
Wallace, GL
AF Kenworthy, Lauren
Case, Laura
Harms, Madeline B.
Martin, Alex
Wallace, Gregory L.
TI Adaptive Behavior Ratings Correlate With Symptomatology and IQ Among
Individuals With High-Functioning Autism Spectrum Disorders
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism; Adaptive behavior; Social skills; IQ; Symptomatology; Asperger's
syndrome
ID DIAGNOSTIC INTERVIEW; DEVELOPMENTAL DISORDERS; CHILDREN; VINELAND;
PREDICTORS; SCALES; RELIABILITY; DEFICITS; DOMAINS; AGE
AB Caregiver report on the Adaptive Behavior Assessment System-II (ABAS) for 40 high-functioning individuals with Autism Spectrum Disorders (ASD) and 30 typically developing (TD) individuals matched for age, IQ, and sex ratio revealed global adaptive behavior deficits in ASD, with social skills impairments particularly prominent. Within the ASD group, adaptive communication skills were positively related to IQ while global adaptive functioning was negatively associated with autism symptomatology. Autistic behavior ratings related negatively to ABAS scores in the TD but not the ASD group. This investigation demonstrates: the utility of an adaptive functioning checklist for capturing impairments, even in high-functioning individuals with ASD; and that a relationship between social abilities and autism exists independently of intelligence.
C1 [Kenworthy, Lauren; Case, Laura; Harms, Madeline B.; Martin, Alex; Wallace, Gregory L.] Childrens Natl Med Ctr, Ctr Autism Spectrum Disorders, Rockville, MD 20850 USA.
[Kenworthy, Lauren] NIMH, Lab Brain & Cognit, Bethesda, MD 20892 USA.
RP Kenworthy, L (reprint author), Childrens Natl Med Ctr, Ctr Autism Spectrum Disorders, 15245 Shady Grove Rd,South Bldg,Suite 350, Rockville, MD 20850 USA.
EM lkenwort@cnmc.org
RI martin, alex/B-6176-2009
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NR 26
TC 17
Z9 17
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD APR
PY 2010
VL 40
IS 4
BP 416
EP 423
DI 10.1007/s10803-009-0911-4
PG 8
WC Psychology, Developmental
SC Psychology
GA 568UZ
UT WOS:000275550200002
PM 19949846
ER
EF