FN Thomson Reuters Web of Science™
VR 1.0
PT J
AU Bakhtiari, R
Sephavand, NM
Ahmadabadi, MN
Araabi, BN
Esteky, H
AF Bakhtiari, Reyhaneh
Sephavand, Nazanin Mohammadi
Ahmadabadi, Majid Nili
Araabi, Babak Nadjar
Esteky, Hossein
TI Computational model of excitatory/inhibitory ratio imbalance role in
attention deficit disorders
SO JOURNAL OF COMPUTATIONAL NEUROSCIENCE
LA English
DT Article
DE Autism; Attention deficit; Excitatory/inhibitory ratio; Competition
ID SELECTIVE VISUAL-ATTENTION; STIMULUS OVER-SELECTIVITY; AUTISM SPECTRUM
DISORDERS; INFERIOR TEMPORAL CORTEX; BIASED COMPETITION;
BINOCULAR-RIVALRY; INFEROTEMPORAL CORTEX; CORTICAL NETWORK; NEURAL
RESPONSES; MODULATION
AB Impairments in attentional behaviors, including over-selectivity, under-selectivity, distractibility and difficulty in shift of attention, are widely reported in several developmental disorders, including autism. Uncharacteristic inhibitory to excitatory neuronal number ratio (IER) and abnormal synaptic strength levels in the brain are two broadly accepted neurobiological disorders observed in autistic individuals. These neurobiological findings are contrasting and their relation to the atypical attentional behaviors is not clear yet. In this paper, we take a computational approach to investigate the relation of imbalanced IER and abnormal synaptic strength to some well-documented spectrum of attentional impairments. The computational model is based on a modified version of a biologically plausible neural model of two competing minicolumns in IT cortex augmented with a simple model of top-down attention. Top-down attention is assumed to amplify (attenuates) attended (unattended) stimulus. The inhibitory synaptic strength parameter in the model is set such that typical attentional behavior is emerged. Then, according to related findings, the parameter is changed and the model's attentional behavior is considered. The simulation results show that, without any change in top-down attention, the abnormal inhibitory synaptic strength values - and IER imbalance- result in over-selectivity, under-selectivity, distractibility and difficulty in shift of attention in the model. It suggests that the modeled neurobiological abnormalities can be accounted for the attentional deficits. In addition, the atypical attentional behaviors do not necessarily point to impairments in top-down attention. Our simulations suggest that limited changes in the inhibitory synaptic strength and variations in top-down attention signal affect the model's attentional behaviors in the same way. So, limited deficits in the inhibitory strength may be alleviated by appropriate change in top-down attention biasing. Nevertheless, our model proposes that this compensation is not possible for very high and very low values of the inhibitory strength.
C1 [Bakhtiari, Reyhaneh; Sephavand, Nazanin Mohammadi; Ahmadabadi, Majid Nili; Araabi, Babak Nadjar] Univ Tehran, Sch Elect & Comp Engn, Coll Engn, Tehran, Iran.
[Bakhtiari, Reyhaneh; Sephavand, Nazanin Mohammadi; Ahmadabadi, Majid Nili; Araabi, Babak Nadjar; Esteky, Hossein] Inst Res Fundamental Sci IPM, Sch Cognit Sci, Tehran, Iran.
[Esteky, Hossein] Univ Shaheed Beheshti Med Sci, Res Ctr Brain & Cognit Sci, Shaheed Beheshti Sch Med, Tehran, Iran.
RP Bakhtiari, R (reprint author), Univ Tehran, Sch Elect & Comp Engn, Coll Engn, Tehran, Iran.
EM r.bakhtiari@ece.ut.ac.ir; n.mohammadi@ece.ut.ac.ir; mnili@ut.ac.ir;
araabi@ut.ac.ir; esteky@ipm.ir
CR Allen G., 2001, FRONTIERS BIOSCIENCE, V6, P105
Baron-Cohen S., 1995, MIND BLINDNESS ESSAY
Belmonte M. K., 2000, AUTISM, V4, P269, DOI DOI 10.1177/1362361300004003004
Belmonte MK, 2004, MOL PSYCHIATR, V9, P646, DOI 10.1038/sj.mp.4001499
Belmonte MK, 2003, COGNITIVE BRAIN RES, V17, P651, DOI 10.1016/S0926-6410(03)00189-7
Bird G, 2006, NEUROIMAGE, V31, P1614, DOI 10.1016/j.neuroimage.2006.02.037
Blake R, 2002, NAT REV NEUROSCI, V3, P13, DOI 10.1038/nrn701
Borgers C, 2008, P NATL ACAD SCI USA, V105, P18023, DOI 10.1073/pnas.0809511105
Broadbent D.E., 1958, PERCEPTION COMMUNICA
Buehlmann A, 2008, J NEUROSCI, V28, P7679, DOI 10.1523/JNEUROSCI.5640-07.2008
Buia C, 2006, J COMPUT NEUROSCI, V20, P247, DOI 10.1007/s10827-006-6358-0
Buia CI, 2008, J NEUROPHYSIOL, V99, P2158, DOI 10.1152/jn.01004.2007
Burack J. A., 1958, ATTENTION AUTISM BEH
Buxhoeveden DP, 2002, BRAIN, V125, P935, DOI 10.1093/brain/awf110
Carlsson ML, 1999, J NEURAL TRANSM, V106, P123, DOI 10.1007/s007020050144
Casanova MF, 2009, PHILOS T R SOC B, V364, P1433, DOI 10.1098/rstb.2008.0331
Casanova MF, 2002, NEUROLOGY, V58, P428
Casanova MF, 2006, ACTA NEUROPATHOL, V112, P287, DOI 10.1007/s00401-006-0085-5
CASEY BJ, 1993, J CLIN EXP NEUROPSYC, V15, P933, DOI 10.1080/01688639308402609
Chelazzi L, 1998, J NEUROPHYSIOL, V80, P2918
Chong SC, 2005, J VISION, V5, P1004, DOI 10.1167/5.11.6
CIESIELSKI KT, 1990, ELECTROEN CLIN NEURO, V75, P207, DOI 10.1016/0013-4694(90)90174-I
Coben R, 2010, APPL PSYCHOPHYS BIOF, V35, P83, DOI 10.1007/s10484-009-9117-y
Coben R, 2010, APPL PSYCHOPHYS BIOF, V35, P13, DOI 10.1007/s10484-009-9102-5
Cowan J., 1994, 25 ANN M ASS APPL PS
Dawson G., 1989, AUTISM NATURE DIAGNO, P49
Deco G, 2005, J NEUROPHYSIOL, V94, P295, DOI 10.1152/jn.01095.2004
Demos J. N., 2005, GETTING STARTED NEUR
Desimone R, 1998, PHILOS T ROY SOC B, V353, P1245, DOI 10.1098/rstb.1998.0280
DESIMONE R, 1995, ANNU REV NEUROSCI, V18, P193, DOI 10.1146/annurev.ne.18.030195.001205
Fries P, 2001, SCIENCE, V291, P1560, DOI 10.1126/science.1055465
Fries P., 2008, J NEUROSCI, V28, P4835
Goldstein G, 2001, J AUTISM DEV DISORD, V31, P433, DOI 10.1023/A:1010620820786
Greenaway R, 2005, PSYCHOL SCI, V16, P987, DOI 10.1111/j.1467-9280.2005.01648.x
Hancocok S., 2007, PERCEPTION, P288
Hughes JR, 2009, EPILEPSY BEHAV, V16, P569, DOI 10.1016/j.yebeh.2009.09.023
Hughes JR, 2008, EPILEPSY BEHAV, V13, P425, DOI 10.1016/j.yebeh.2008.06.015
Jamain S, 2002, MOL PSYCHIATR, V7, P302, DOI 10.1038/sj/mp/4000979
Jarusiewicz B., 2002, J NEUROTHERAPY, V6, P39, DOI [10.1300/j184v06n04_05, DOI 10.1300/J184V06N04_05]
Kastner S, 2001, NEUROPSYCHOLOGIA, V39, P1263, DOI 10.1016/S0028-3932(01)00116-6
Kiani R, 2007, J NEUROPHYSIOL, V97, P4296, DOI 10.1152/jn.00024.2007
Korvatska E, 2002, NEUROBIOL DIS, V9, P107, DOI 10.1006/nbdi.2002.0479
Kouijzer MEJ, 2009, RES AUTISM SPECT DIS, V3, P145, DOI 10.1016/j.rasd.2008.05.001
Landry R, 2004, J CHILD PSYCHOL PSYC, V45, P1115, DOI 10.1111/j.1469-7610.2004.00304.x
Levelt W. J. M., 1965, BINOCULAR RIVALRY
Linden M., 2004, 12 ANN C INT SOC NEU
Logothetis NK, 1996, ANNU REV NEUROSCI, V19, P577, DOI 10.1146/annurev.ne.19.030196.003045
LOVAAS OI, 1971, J ABNORM PSYCHOL, V77, P211, DOI 10.1037/h0031015
Matthews B, 2001, J INTELLECT DEV DIS, V26, P161
Mirpour K, 2009, J NEUROPHYSIOL, V102, P1790, DOI 10.1152/jn.91197.2008
Moldakarimov S, 2005, J NEUROPHYSIOL, V94, P3388, DOI 10.1152/jn.00159.2005
Ohshiro T, 2011, NAT NEUROSCI, V14, P775, DOI 10.1038/nn.2815
Paffen C. L., 2011, FRONT HUM NEUROSCI, P1
Paffen CLE, 2006, PSYCHOL SCI, V17, P752, DOI 10.1111/j.1467-9280.2006.01777.x
Paffen CLE, 2011, SEEING PERCEIVING, V24, P19, DOI 10.1163/187847510X554069
Polleux F, 2004, MENT RETARD DEV D R, V10, P303, DOI 10.1002/mrdd.20044
Purcell AE, 2001, NEUROLOGY, V57, P1618
Reed P, 2005, J AUTISM DEV DISORD, V35, P601, DOI 10.1007/s10803-005-0004-y
Remington A, 2009, PSYCHOL SCI, V20, P1388, DOI 10.1111/j.1467-9280.2009.02454.x
Reynolds J., 1999, J NEUROSCI, V1, P1736
Reynolds JH, 2000, NEURON, V26, P703, DOI 10.1016/j.neuron.2009.01.002
Rinehart NJ, 2001, AUTISM, V5, P67, DOI 10.1177/1362361301005001007
Rollenhagen E., 2005, J NEUROPHYSIOL, V94, P3368
Rubenstein JLR, 2003, GENES BRAIN BEHAV, V2, P255, DOI 10.1046/j.1601-183X.2003.00037.x
Ruggieri V. L., 2006, REV NEUROLOGIA, V42, P51
Steinmetz PN, 2000, NATURE, V404, P187
Swettenham J, 1998, J CHILD PSYCHOL PSYC, V39, P747, DOI 10.1017/S0021963098002595
Tanaka K, 1996, ANNU REV NEUROSCI, V19, P109, DOI 10.1146/annurev.ne.19.030196.000545
TOWNSEND J, 1994, J COGNITIVE NEUROSCI, V6, P220, DOI 10.1162/jocn.1994.6.3.220
Wang XJ, 2002, NEURON, V36, P955, DOI 10.1016/S0896-6273(02)01092-9
White S, 2009, NEUROPSYCHOLOGIA, V47, P1274, DOI 10.1016/j.neuropsychologia.2009.01.012
WILHELM H, 1976, AM J MENT DEF, V81, P26
NR 72
TC 4
Z9 4
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0929-5313
J9 J COMPUT NEUROSCI
JI J. Comput. Neurosci.
PD OCT
PY 2012
VL 33
IS 2
BP 389
EP 404
DI 10.1007/s10827-012-0391-y
PG 16
WC Mathematical & Computational Biology; Neurosciences
SC Mathematical & Computational Biology; Neurosciences & Neurology
GA 005BN
UT WOS:000308725400009
PM 22566142
ER
PT J
AU Koegel, LK
Vernon, TW
Koegel, RL
Koegel, BL
Paullin, AW
AF Koegel, Lynn K.
Vernon, Ty W.
Koegel, Robert L.
Koegel, Brittany L.
Paullin, Anne W.
TI Improving Social Engagement and Initiations Between Children With Autism
Spectrum Disorder and Their Peers in Inclusive Settings
SO JOURNAL OF POSITIVE BEHAVIOR INTERVENTIONS
LA English
DT Article
DE initiations; inclusion; peers; socialization; social communication;
autism
ID ASPERGER-SYNDROME; YOUNG-CHILDREN; SKILLS; INTERVENTIONS; DISABILITIES;
INDIVIDUALS; LONELINESS; VALIDITY; STUDENTS; BEHAVIOR
AB Research suggests that incorporating the circumscribed ritualistic interests of children with autism as a theme of activities can improve their socialization. The current study assessed whether socialization would improve if more general interests of children on the autism spectrum that would also be of interest to their typical peers were incorporated into activities. Three children with autism, who were included in regular education classes but did not seek out or interact with peers prior to intervention, participated. Data were collected in the context of a multiple baseline across-participants design, with a reversal for one child. Activities that were identified to be of interest to the study participants and their typical peers were implemented as clubs twice weekly during regular lunchtime periods. Results showed that all three children demonstrated large increases in their time engaged with peers as a result of the activities, with minimal training of the interventionist and without any specialized training of the children with autism or their peers. Furthermore, their untargeted verbal initiations greatly improved over baseline levels and often approximated the levels of their peers. Implications for further improving peer social interactions for children with Autism Spectrum Disorder are discussed.
C1 [Koegel, Lynn K.] Univ Calif Santa Barbara, Grad Sch Educ, Autism Res Ctr, CCS Psychol Clin, Santa Barbara, CA 93106 USA.
[Paullin, Anne W.] Harvard Univ, Cambridge, MA 02138 USA.
RP Koegel, LK (reprint author), Univ Calif Santa Barbara, Grad Sch Educ, Autism Res Ctr, CCS Psychol Clin, Santa Barbara, CA 93106 USA.
EM lynnk@education.ucsb.edu
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
Baker MJ, 1998, J ASSOC PERS SEVERE, V23, P300, DOI 10.2511/rpsd.23.4.300
Bauminger N, 2000, CHILD DEV, V71, P447, DOI 10.1111/1467-8624.00156
Chan JM, 2009, RES AUTISM SPECT DIS, V3, P876, DOI 10.1016/j.rasd.2009.04.003
Christ TJ, 2007, PSYCHOL SCHOOLS, V44, P451, DOI 10.1002/pits.20237
Garrison-Harrell L., 1997, FOCUS AUTISM OTHER D, V12, P241, DOI DOI 10.1177/108835769701200406
Gonzalez-Lopez A., 1997, FOCUS AUTISM OTHER D, V12, P2
Gresham FM, 2001, EXCEPT CHILDREN, V67, P331
GRESHAM FM, 1981, REV EDUC RES, V51, P139
GRESHAM FM, 1981, J SCHOOL PSYCHOL, V19, P120, DOI 10.1016/0022-4405(81)90054-6
Gumpel TP, 2007, PSYCHOL SCHOOLS, V44, P351, DOI 10.1002/pits.20229
Hayes S. C., 1999, SCI PRACTITIONER RES
Howlin P, 2000, AUTISM, V4, P63, DOI DOI 10.1177/1362361300004001005
Ingersoll B., 2009, J POSIT BEHAV INTERV, V12, P33
Jennes-Coussens M, 2006, AUTISM, V10, P403, DOI 10.1177/1362361306064432
Jobe LE, 2007, PERS INDIV DIFFER, V42, P1479, DOI 10.1016/j.paid.2006.10.021
Jones R. S. P., 2001, J LEARNING DISABILIT, V5, P35, DOI DOI 10.1177/146900470100500104
Kalyva E, 2005, J APPL RES INTELLECT, V18, P253, DOI 10.1111/j.1468-3148.2005.00232.x
Kavale KA, 2004, LEARN DISABILITY Q, V27, P31, DOI 10.2307/1593630
Kazdin A. E., 1982, SINGLE CASE EXPT DES
Klin A, 2007, RES PRACT PERS SEV D, V32, P89
Koegel R. L., 2006, PIVOTAL RESPONSE TRE
McConnell SR, 2002, J AUTISM DEV DISORD, V32, P351, DOI 10.1023/A:1020537805154
McGee GG, 1997, J AUTISM DEV DISORD, V27, P353, DOI 10.1023/A:1025849220209
Morrison L., 2001, J POSIT BEHAV INTERV, V3, P237, DOI DOI 10.1177/109830070100300405
Pierce K., 1997, FOCUS AUTISM OTHER D, V12, P207
Rogers SJ, 2000, J AUTISM DEV DISORD, V30, P399, DOI 10.1023/A:1005543321840
Scott TM, 2007, J POSIT BEHAV INTERV, V9, P102, DOI 10.1177/10983007070090020101
Stewart ME, 2006, AUTISM, V10, P103, DOI 10.1177/1362361306062013
Strain P. S., 2001, FOCUS AUTISM OTHER D, V16, P120, DOI DOI 10.1177/108835760101600208
NR 30
TC 14
Z9 14
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1098-3007
J9 J POSIT BEHAV INTERV
JI J. Posit. Behav. Interv.
PD OCT
PY 2012
VL 14
IS 4
BP 220
EP 227
DI 10.1177/1098300712437042
PG 8
WC Psychology, Clinical; Education, Special
SC Psychology; Education & Educational Research
GA 000UD
UT WOS:000308413400004
ER
PT J
AU Walton, KM
Ingersoll, BR
AF Walton, Katherine M.
Ingersoll, Brooke R.
TI Evaluation of a Sibling-Mediated Imitation Intervention for Young
Children With Autism
SO JOURNAL OF POSITIVE BEHAVIOR INTERVENTIONS
LA English
DT Article
DE children with autism; family-based interventions; siblings; imitation
ID BEHAVIORAL INTERVENTION; RECIPROCAL INTERACTIONS; SOCIAL-INTERACTION;
JOINT ATTENTION; SKILLS; PLAY; PEER; DEFICITS
AB Parents and peers have been successful at implementing interventions targeting social interactions in children with autism; however, few interventions have trained siblings as treatment providers. This study used a multiple-baseline design across six sibling dyads (four children with autism) to evaluate the efficacy of sibling-implemented reciprocal imitation training. All six typically developing siblings were able to learn and use contingent imitation, four of the six siblings were able to learn and use linguistic mapping, and all six siblings increased their use of at least one component of the imitation training procedure. Three of the four children with autism showed increases in overall imitation and all four showed evidence of increases in joint engagement. Parents and siblings reported high satisfaction with the intervention, and ratings by naive observers indicated significant changes from pre- to posttreatment. These results suggest that sibling-implemented reciprocal imitation training may be a promising intervention for young children with autism.
C1 [Walton, Katherine M.; Ingersoll, Brooke R.] Michigan State Univ, E Lansing, MI 48824 USA.
RP Walton, KM (reprint author), Michigan State Univ, 69F Psychol Bldg, E Lansing, MI 48824 USA.
EM ktmeyer15@gmail.com
RI Ingersoll, Brooke/A-9117-2012
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
Bayley N, 2006, BAYLEY SCALES INFANT, V3rd
CELIBERTI DA, 1993, BEHAV THER, V24, P573, DOI 10.1016/S0005-7894(05)80319-3
COE DA, 1991, CHILD FAM BEHAV THER, V13, P13, DOI 10.1300/J019v13n03_02
Drew A, 2002, EUR CHILD ADOLES PSY, V11, P266, DOI 10.1007/s00787-002-0299-6
ECKERMAN CO, 1989, CHILD DEV, V60, P440, DOI 10.2307/1130988
El-Ghoroury NH, 1999, J AUTISM DEV DISORD, V29, P249, DOI 10.1023/A:1023036223397
Fenson L, 1993, MACARTHUR COMMUNICAT
Field T, 2001, AUTISM, V5, P317, DOI 10.1177/1362361301005003008
HARTMANN DP, 1977, J APPL BEHAV ANAL, V10, P103, DOI 10.1901/jaba.1977.10-103
Ingersoll B, 2007, J AUTISM DEV DISORD, V37, P1446, DOI 10.1007/s10803-006-0221-z
Ingersoll B, 2006, J AUTISM DEV DISORD, V36, P487, DOI 10.1007/s10803-006-0089-y
Ingersoll B, 2010, J AUTISM DEV DISORD, V40, P1154, DOI 10.1007/s10803-010-0966-2
Ingersoll B, 2008, INFANT YOUNG CHILD, V21, P107
Ingersoll B, 2007, RES DEV DISABIL, V28, P163, DOI 10.1016/j.ridd.2006.02.004
JAMES SD, 1986, J APPL BEHAV ANAL, V19, P173, DOI 10.1901/jaba.1986.19-173
Kasari C, 2010, J AUTISM DEV DISORD, V40, P1045, DOI 10.1007/s10803-010-0955-5
LEWY AL, 1992, J ABNORM CHILD PSYCH, V20, P555, DOI 10.1007/BF00911240
Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
McConnell SR, 2002, J AUTISM DEV DISORD, V32, P351, DOI 10.1023/A:1020537805154
MCGEE GG, 1992, J APPL BEHAV ANAL, V25, P117, DOI 10.1901/jaba.1992.25-117
PIERCE K, 1995, J APPL BEHAV ANAL, V28, P285, DOI 10.1901/jaba.1995.28-285
Rogers SJ, 2000, J AUTISM DEV DISORD, V30, P399, DOI 10.1023/A:1005543321840
SCHWARTZ IS, 1991, J APPL BEHAV ANAL, V24, P189, DOI 10.1901/jaba.1991.24-189
Scruggs TE, 1998, BEHAV MODIF, V22, P221, DOI 10.1177/01454455980223001
Trent JA, 2005, TOP EARLY CHILD SPEC, V25, P107, DOI 10.1177/02711214050250020101
Tsao LL, 2006, TOP EARLY CHILD SPEC, V26, P106, DOI 10.1177/02711214060260020101
NR 27
TC 5
Z9 5
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1098-3007
J9 J POSIT BEHAV INTERV
JI J. Posit. Behav. Interv.
PD OCT
PY 2012
VL 14
IS 4
BP 241
EP 253
DI 10.1177/1098300712437044
PG 13
WC Psychology, Clinical; Education, Special
SC Psychology; Education & Educational Research
GA 000UD
UT WOS:000308413400006
ER
PT J
AU Kandalaft, MR
Didehbani, N
Cullum, CM
Krawczyk, DC
Allen, TT
Tamminga, CA
Chapman, SB
AF Kandalaft, Michelle R.
Didehbani, Nyaz
Cullum, C. Munro
Krawczyk, Daniel C.
Allen, Tandra T.
Tamminga, Carol A.
Chapman, Sandra B.
TI The Wechsler ACS Social Perception Subtest: A Preliminary Comparison
With Other Measures of Social Cognition
SO JOURNAL OF PSYCHOEDUCATIONAL ASSESSMENT
LA English
DT Article
DE advanced clinical solutions; WAIS-IV; social perception; Asperger;
schizophrenia; social cognition
ID HIGH-FUNCTIONING AUTISM; EMOTION RECOGNITION; ASPERGER-SYNDROME;
ECOLOGICAL VALIDITY; PARKINSONS-DISEASE; SCHIZOPHRENIA; MIND; ADULTS;
ATTRIBUTION; PERFORMANCE
AB Relative to other cognitive areas, there are few clinical measures currently available to assess social perception. A new standardized measure, the Wechsler Advanced Clinical Solutions (ACS) Social Perception subtest, addresses some limitations of existing measures; however, little is known about this new test. The first goal of this investigation was to preliminarily explore the relationship of the ACS Social Perception subtest to five other measures of social perception and cognition in a sample of control subjects and individuals with Asperger Syndrome and schizophrenia. A secondary goal was to preliminarily explore the differences between groups on six measures of social perception and cognition. Results revealed several significant correlations between the ACS Social Perception subtest and other measures of social cognition, and some evidence for the distinguishing abilities of the measure. The ACS Social Perception subtest appears to be a promising measure for the evaluation of social perceptive skills.
C1 [Kandalaft, Michelle R.] Univ Texas Dallas, Ctr BrainHlth, Dallas, TX 75235 USA.
[Cullum, C. Munro; Krawczyk, Daniel C.; Tamminga, Carol A.] Univ Texas SW Med Ctr Dallas, Dallas, TX USA.
RP Kandalaft, MR (reprint author), Univ Texas Dallas, Ctr BrainHlth, 2200 W Mockingbird Lane, Dallas, TX 75235 USA.
EM kandalaft@utdallas.edu
CR Abell F, 2000, COGNITIVE DEV, V15, P1, DOI 10.1016/S0885-2014(00)00014-9
Ariatti A, 2008, NEUROL SCI, V29, P219, DOI 10.1007/s10072-008-0971-9
Ashwin C, 2006, SOC NEUROSCI, V1, P349, DOI 10.1080/17470910601040772
Banziger T, 2009, EMOTION, V9, P691, DOI 10.1037/a0017088
Baron-Cohen S, 2001, J CHILD PSYCHOL PSYC, V42, P241, DOI 10.1017/S0021963001006643
Bell MD, 2010, SCHIZOPHR RES, V122, P164, DOI 10.1016/j.schres.2010.03.024
Bowers D., 1993, NEUROPSYCHOLOGY, V7, P433, DOI 10.1037//0894-4105.7.4.433
Brune M, 2005, SCHIZOPHRENIA BULL, V31, P21, DOI 10.1093/schbul/sbi002
Brune M, 2005, PSYCHIAT RES, V133, P135, DOI 10.1016/j.psychres.2004.10.007
Castelli F, 2000, NEUROIMAGE, V12, P314, DOI 10.1006/nimg.2000.0612
Couture SM, 2006, SCHIZOPHRENIA BULL, V32, pS44, DOI 10.1093/schbul/sb1029
Dennis M, 2009, J INT NEUROPSYCH SOC, V15, P331, DOI 10.1017/S1355617709090481
Ekman P., 1969, SEMIOTICA, V1, P49
First MB, 1995, STRUCTURED CLIN INTE
Golan O, 2007, J AUTISM DEV DISORD, V37, P1096, DOI 10.1007/s10803-006-0252-5
Golan O, 2006, DEV PSYCHOPATHOL, V18, P591, DOI 10.1017/S0954579406060305
Gray HA, 2010, NEUROPSYCHOLOGY, V24, P176, DOI 10.1037/a0018104
Green MF, 2005, SCHIZOPHRENIA BULL, V31, P882, DOI 10.1093/schbul/sbi049
Green MF, 2008, SCHIZOPHRENIA BULL, V34, P1211, DOI 10.1093/schbul/sbm145
Heider F, 1944, AM J PSYCHOL, V57, P243, DOI 10.2307/1416950
Holdnack J, 2011, ASSESSMENT, V18, P192, DOI 10.1177/1073191110394771
Hooker C, 2002, PSYCHIAT RES, V112, P41, DOI 10.1016/S0165-1781(02)00177-4
Karow Colleen M., 2003, Seminars in Speech and Language, V24, P69, DOI 10.1055/s-2003-38900
Knox L, 2009, BRAIN COGNITION, V69, P442, DOI 10.1016/j.bandc.2008.09.009
Kujala T, 2005, NEUROSCI LETT, V383, P260, DOI 10.1016/j.neulet.2005.04.048
Lord C., 2002, AUTISM DIAGNOSTIC OB
Mayer JD, 2003, EMOTION, V3, P97, DOI 10.1037/1528-3542.3.1.97
McDonald S, 2004, NEUROPSYCHOL REHABIL, V14, P285, DOI 10.1080/09602010343000237
Nuechterlein KH, 2008, AM J PSYCHIAT, V165, P203, DOI 10.1176/appi.ajp.2007.07010042
Nuechterlein KH, 2006, MATRICS CONSENSUS CO
Pearson, 2009, ADV CLIN SOULT WAIS
Penn DL, 2008, SCHIZOPHRENIA BULL, V34, P408, DOI 10.1093/schbul/sbn014
Philip RCM, 2010, PSYCHOL MED, V40, P1919, DOI 10.1017/S0033291709992364
Pinkham AE, 2003, AM J PSYCHIAT, V160, P815, DOI 10.1176/appi.ajp.160.5.815
Poole JH, 2000, J INT NEUROPSYCH SOC, V6, P649, DOI 10.1017/S135561770066602X
Sasson NJ, 2011, J NEURODEV DISORD, V3, P87, DOI 10.1007/s11689-010-9068-x
Sasson NJ, 2006, J AUTISM DEV DISORD, V36, P381, DOI 10.1007/s10803-006-0076-3
SCHERER KR, 1986, PSYCHOL BULL, V99, P143, DOI 10.1037//0033-2909.99.2.143
Vaskinn A, 2009, J NERV MENT DIS, V197, P700, DOI 10.1097/NMD.0b013e3181b3ae62
Wechsler D, 1999, WECHSLER ABBREVIATED
Wechsler DS, 1997, WECHSLER MEMORY SCAL
Wexler BE, 2009, SCHIZOPHRENIA BULL, V35, P250
Wolwer W, 2005, SCHIZOPHR RES, V80, P295, DOI 10.1016/j.schres.2005.07.018
Young AW, 2002, FACIAL EXPRESSIONS E
NR 44
TC 2
Z9 2
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0734-2829
J9 J PSYCHOEDUC ASSESS
JI J. Psychoeduc. Assess.
PD OCT
PY 2012
VL 30
IS 5
BP 455
EP 465
DI 10.1177/0734282912436411
PG 11
WC Psychology, Educational
SC Psychology
GA 000TY
UT WOS:000308412900001
ER
PT J
AU Brugha, TS
AF Brugha, T. S.
TI Autism Spectrum Disorders
SO PSYCHOLOGICAL MEDICINE
LA English
DT Book Review
EM tsb@le.ac.uk
CR Amaral D., 2011, AUTISM SPECTRUM DISO
NR 1
TC 0
Z9 0
PU CAMBRIDGE UNIV PRESS
PI NEW YORK
PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA
SN 0033-2917
J9 PSYCHOL MED
JI Psychol. Med.
PD OCT
PY 2012
VL 42
IS 10
BP 2235
EP 2236
DI 10.1017/S0033291712001596
PG 2
WC Psychology, Clinical; Psychiatry; Psychology
SC Psychology; Psychiatry
GA 006UR
UT WOS:000308845200021
ER
PT J
AU Brugha, TS
AF Brugha, T. S.
TI Autism Spectrum Disorders Through the Life Span
SO PSYCHOLOGICAL MEDICINE
LA English
DT Book Review
EM tsb@le.ac.uk
CR TANTAM D, 2011, AUTISM SPECTRUM DISO
NR 1
TC 0
Z9 0
PU CAMBRIDGE UNIV PRESS
PI NEW YORK
PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA
SN 0033-2917
J9 PSYCHOL MED
JI Psychol. Med.
PD OCT
PY 2012
VL 42
IS 10
BP 2236
EP 2237
DI 10.1017/S0033291712001602
PG 2
WC Psychology, Clinical; Psychiatry; Psychology
SC Psychology; Psychiatry
GA 006UR
UT WOS:000308845200022
ER
PT J
AU Meltzer, LJ
Montgomery-Downs, HE
Insana, SP
Walsh, CM
AF Meltzer, Lisa J.
Montgomery-Downs, Hawley E.
Insana, Salvatore P.
Walsh, Colleen M.
TI Use of actigraphy for assessment in pediatric sleep research
SO SLEEP MEDICINE REVIEWS
LA English
DT Review
DE Accelerometer; Actigraphy; Adolescents; Children; Infants; Pediatric;
Sleep; Wake
ID ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; SCHOOL-AGE-CHILDREN;
DEFICIT-HYPERACTIVITY DISORDER; HIGH-FUNCTIONING AUTISM; MELATONIN
IMPROVES SLEEP; REST-ACTIVITY RHYTHM; INFANT SLEEP; ONSET INSOMNIA; WAKE
PATTERNS; ASPERGER-SYNDROME
AB The use of actigraphs, or ambulatory devices that estimate sleep-wake patterns from activity levels, has become common in pediatric research. Actigraphy provides a more objective measure than parent-report, and has gained popularity due to its ability to measure sleep-wake patterns for extended periods of time in the child's natural environment. The purpose of this review is: 1) to provide comprehensive information on the historic and current uses of actigraphy in pediatric sleep research; 2) to review how actigraphy has been validated among pediatric populations; and 3) offer recommendations for methodological areas that should be included in all studies that utilize actigraphy, including the definition and scoring of variables commonly reported. The poor specificity to detect wake after sleep onset was consistently noted across devices and age groups, thus raising concerns about what is an "acceptable" level of specificity for actigraphy. Other notable findings from this review include the lack of standard scoring rules or variable definitions. Suggestions for the use and reporting of actigraphy in pediatric research are provided. (C) 2011 Elsevier Ltd. All rights reserved.
C1 [Meltzer, Lisa J.] Natl Jewish Hlth, Denver, CO 80206 USA.
[Montgomery-Downs, Hawley E.] W Virginia Univ, Morgantown, WV 26506 USA.
[Insana, Salvatore P.] Univ Pittsburgh, Med Ctr, Pittsburgh, PA 15213 USA.
[Walsh, Colleen M.] Drexel Univ, Philadelphia, PA 19104 USA.
RP Meltzer, LJ (reprint author), Natl Jewish Hlth, 1400 Jackson St,G311, Denver, CO 80206 USA.
EM meltzerL@njhealth.org; Hawley.Montgomery-Downs@mail.wvu.edu;
insanas@upmc.edu; Colleen.walsh@uphs.upenn.edu
FU [K23 MH066772]
FX We thank Devon Ambler for her assistance with the references. Support
for this manuscript was provided by K23 MH066772.
CR Acebo Christine, 2006, Respir Care Clin N Am, V12, P23
Acebo C, 1999, SLEEP, V22, P95
Acebo C, 2005, SLEEP, V28, P1568
Acebo C, 2006, RESP CARE CLIN N AM, V12, pviii
Allik H, 2006, BMC PSYCHIATRY, V6, DOI 10.1186/1471-244X-6-18
Allik H, 2006, J AUTISM DEV DISORD, V36, P585, DOI 10.1007/s10803-006-0099-9
Allik H, 2008, J AUTISM DEV DISORD, V38, P1625, DOI 10.1007/s10803-008-0543-0
ALTMAN DG, 1983, J R STAT SOC D-STAT, V32, P307, DOI DOI 10.2307/2987937
Amin R, 2005, CHEST, V128, P1357, DOI 10.1378/chest.128.3.1357
Anderson B, 2009, PEDIATRICS, V123, pE701, DOI 10.1542/peds.2008-1182
Angulo-Kinzler, 2002, EARLY HUM DEV, V70, P85
Armitage R, 2009, SLEEP, V32, P693
Asaka Y, 2010, BRAIN DEV-JPN, V32, P150, DOI 10.1016/j.braindev.2008.12.006
Beebe DW, 2008, J CHILD PSYCHOL PSYC, V49, P915, DOI 10.1111/j.1469-7610.2008.01885.x
Beebe DW, 2007, J PEDIATR PSYCHOL, V32, P69, DOI 10.1093/jpepsy/jsj104
Beijamini F, 2008, BRAZ J MED BIOL RES, V41, P734, DOI 10.1590/S0100-879X2008000800016
Berger AM, 2008, J PAIN SYMPTOM MANAG, V36, P191, DOI 10.1016/j.jpainsymman.2007.10.008
Blumer JL, 2008, CLIN PHARMACOL THER, V83, P551, DOI 10.1038/sj.clpt.6100380
Bruni O, 2004, CEPHALALGIA, V24, P134, DOI 10.1111/j.1468-2982.2004.00657.x
Buckhalt JA, 2009, CHILD DEV, V80, P875, DOI 10.1111/j.1467-8624.2009.01303.x
Buckhalt JA, 2007, CHILD DEV, V78, P213, DOI 10.1111/j.1467-8624.2007.00993.x
Burnham MM, 2007, INFANT CHILD DEV, V16, P341, DOI 10.1002/icd.520
Bursztein C, 2006, J CHILD NEUROL, V21, P1012, DOI 10.2310/7010.2006.00239
Caldwell-Andrews AA, 2006, PEDIATR ANESTH, V16, P144, DOI 10.1111/j.1460-9592.2005.01706.x
Campbell IG, 2007, SLEEP, V30, P1677
Carskadon MA, 1998, SLEEP, V21, P871
Carskadon MA, 1997, J BIOL RHYTHM, V12, P278, DOI 10.1177/074873049701200309
Cavallo A, 2004, J PINEAL RES, V36, P262, DOI 10.1111/j.1600-079X.2004.00126.x
COLE RJ, 1992, SLEEP, V15, P461
Corkum P, 2001, SLEEP, V24, P303
Corkum P, 2007, J PEDIAT PSYCHOL, V33
Crabtree VM, 2003, CLIN PEDIATR, V42, P807, DOI 10.1177/000992280304200906
Crowley SJ, 2010, CHRONOBIOL INT, V27, P1469, DOI 10.3109/07420528.2010.503293
Cubero J, 2007, NEUROENDOCRINOL LETT, V28, P360
Cubero J, 2009, NUTR NEUROSCI, V12, P272, DOI 10.1179/147683009X423490
Dagan Y, 1997, PSYCHIAT CLIN NEUROS, V51, P383, DOI 10.1111/j.1440-1819.1997.tb02604.x
de LH, 2001, J PEDIAT, V139, P111
de Castro-Silva C, 2010, J PINEAL RES, V48, P65, DOI 10.1111/j.1600-079X.2009.00726.x
El-Sheikh M, 2007, J FAM PSYCHOL, V21, P29, DOI 10.1037/0893-3200.21.1.29
El-Sheikh M, 2007, J SLEEP RES, V16, P396, DOI 10.1111/j.1365-2869.2007.00618.x
El-Sheikh M, 2010, J CHILD PSYCHOL PSYC, V51, P188, DOI 10.1111/j.1469-7610.2009.02140.x
El-Sheikh M, 2011, J SLEEP RES, V20, P326, DOI 10.1111/j.1365-2869.2010.00880.x
El-Sheikh M, 2010, CHILD DEV, V81, P870, DOI 10.1111/j.1467-8624.2010.01439.x
El-Sheikh M, 2005, DEV PSYCHOBIOL, V46, P307, DOI 10.1002/dev.20066
El-Sheikh M, 2007, J CHILD PSYCHOL PSYC, V48, P88, DOI 10.1111/j.1469-7610.2006.01604.x
El-Sheikh M, 2006, CHILD DEV, V77, P31, DOI 10.1111/j.1467-8624.2006.00854.x
El-Sheikh M, 2008, HEALTH PSYCHOL, V27, P26, DOI 10.1037/0278-6133.27.1.26
El-Sheikh M, 2007, J SLEEP RES, V16, P188, DOI 10.1111/j.1365-2869.2007.00593.x
Epstein R, 1997, SLEEP, V20, P334
Fallone G, 2002, SLEEP, V25, P739
Ferber SG, 2002, J DEV BEHAV PEDIATR, V23, P410
Floro JN, 2009, RES Q EXERCISE SPORT, V80, P153
Franck LS, 1999, PEDIATRICS, V104, DOI 10.1542/peds.104.5.e62
Gaina A, 2004, SLEEP HYPNOSIS, V6, P66
Gaina A, 2005, SLEEP, V28, P337
Gaina A, 2004, J EPIDEMIOL, V14, P1, DOI 10.2188/jea.14.1
Gallagher MR, 2010, HISPANIC HLTH CARE I, V8, P209
Gedaly-Duff V, 2006, ONCOL NURS FORUM, V33, P641, DOI 10.1188/06.ONF.641-646
Geiger A, 2010, DEV PSYCHOL, V46, P949, DOI 10.1037/a0019679
German A, 2008, J CLIN ENDOCR METAB, V93, P4707, DOI 10.1210/jc.2008-0519
GERSHONIBARUCH R, 1994, DEV MED CHILD NEUROL, V36, P639
Gertner S, 2002, EARLY HUM DEV, V68, P93, DOI 10.1016/S0378-3782(02)00018-X
Giblin JM, 2010, J ATTEN DISORD, V15, P491
Gnidovec B, 2002, CLIN NEUROPHYSIOL, V113, P1815, DOI 10.1016/S1388-2457(02)00287-0
Goldman SE, 2009, DEV NEUROPSYCHOL, V34, P560, DOI 10.1080/87565640903133509
Goodlin-Jones B, 2009, J AM ACAD CHILD PSY, V48, P847, DOI 10.1097/CHI.0b013e3181a8135a
Goodlin-Jones B, 2009, J CHILD PSYCHOL PSYC, V50, P1532, DOI 10.1111/j.1469-7610.2009.02110.x
Goodlin-Jones BL, 2008, J DEV BEHAV PEDIATR, V29, P82, DOI 10.1097/DBP.0b013e318163c39a
Goodlin-Jones BL, 2009, CHILD PSYCHIAT HUM D, V40, P257, DOI 10.1007/s10578-009-0124-2
Goodlin-Jones BL, 2008, J AM ACAD CHILD PSY, V47, P930, DOI [10.1097/CHI.ObO13e3181799f7c, 10.1097/CHI.0b013e3181799f7c]
Gruber R, 2000, J AM ACAD CHILD PSY, V39, P495, DOI 10.1097/00004583-200004000-00019
Gruber R, 2010, SLEEP MED, V11, P289, DOI 10.1016/j.sleep.2009.09.007
Gruber R, 2004, SLEEP, V27, P267
Gruber R, 2007, SLEEP, V30, P1003
Gruber R, 2006, J AM ACAD CHILD PSY, V45, P982, DOI 10.1097/01.chi.0000220848.48650.10
Guilleminault C, 1996, NEUROPHYSIOL CLIN, V26, P21, DOI 10.1016/0987-7053(96)81531-0
Gupta NK, 2002, AM J HUM BIOL, V14, P762, DOI 10.1002/ajhb.10093
Haim A, 2004, ACTA PAEDIATR, V93, P677, DOI 10.1080/08035250310007466
Hall W A, 2006, Behav Sleep Med, V4, P242, DOI 10.1207/s15402010bsm0404_4
Hasler BP, 2008, BEHAV SLEEP MED, V6, P55, DOI 10.1080/15402000701796049
Hatzinger M, 2010, J PSYCHIATR RES, V44, P253, DOI 10.1016/j.jpsychires.2009.08.012
HEIKKILA E, 1995, AM J MED GENET, V57, P229, DOI 10.1002/ajmg.1320570223
Hering E, 1999, J AUTISM DEV DISORD, V29, P143, DOI 10.1023/A:1023092627223
Hinds PS, 2007, CANCER-AM CANCER SOC, V110, P2321, DOI 10.1002/cncr.23039
Hinds PS, 2007, ONCOL NURS FORUM, V34, P393, DOI 10.1188/07.ONF.393-402
Hinds PS, 2007, J PAIN SYMPTOM MANAG, V33, P686, DOI 10.1016/j.jpainsymman.2006.09.025
Hockenberry Marilyn J, 2010, Oncol Nurs Forum, V37, pE16, DOI 10.1188/10.ONF.E16-E27
Holley S, 2010, BEHAV SLEEP MED, V8, P16, DOI 10.1080/15402000903425462
Hourmand-Ollivier I, 2006, WORLD J GASTROENTERO, V12, P2243
Huynh Christophe, 2010, Int J Adolesc Med Health, V22, P547
Hvolby A, 2011, NORD J PSYCHIAT, V65, P89, DOI 10.3109/08039488.2010.501868
Hvolby A, 2008, ARCH PEDIAT ADOL MED, V162, P323, DOI 10.1001/archpedi.162.4.323
Hyde M, 2007, J SLEEP RES, V16, P213, DOI 10.1111/j.1365-2869.2007.00588.x
Iber C, 2007, AASM MANUAL SCORING
Insana SP, 2010, SLEEP MED, V11, P191, DOI 10.1016/j.sleep.2009.08.010
Ironside S, 2010, J SLEEP RES, V19, P546, DOI 10.1111/j.1365-2869.2010.00845.x
Iwasaki M, 2010, J EPIDEMIOL, V20, P143, DOI 10.2188/jea.JE20090054
Iwata S, 2011, INT J DEV NEUROSCI, V29, P57, DOI 10.1016/j.ijdevneu.2010.09.004
Javaheri S, 2011, J PEDIATR-US, V158, P617, DOI 10.1016/j.jpeds.2010.09.080
Javaheri S, 2008, CIRCULATION, V118, P1034, DOI 10.1161/CIRCULATIONAHA.108.766410
Jenni OG, 2006, INFANT BEHAV DEV, V29, P143, DOI 10.1016/j.infbeh.2005.11.001
Jenni OG, 2005, NORMAL HUMAN SLEEP D, P11
Johnson NL, 2007, SLEEP, V30, P899
Jones SH, 2006, BIPOLAR DISORD, V8, P362, DOI 10.1111/j.1399-5618.2006.00329.x
Jonsdottir S, 2004, NEUROREHAB NEURAL RE, V18, P212, DOI 10.1177/1545968304270759
Kain ZN, 2002, ANESTHESIOLOGY, V97, P1093, DOI 10.1097/00000542-200211000-00010
Kain ZN, 2005, ANESTHESIOLOGY, V102, P720, DOI 10.1097/00000542-200504000-00005
Kaufman Y, 2001, PEDIATR NEUROL, V24, P129, DOI 10.1016/S0887-8994(00)00254-X
Keller PS, 2008, J DEV BEHAV PEDIATR, V29, P441, DOI 10.1097/DBP.0b013e318182a9b4
Kieckhefer GM, 2008, J DEV BEHAV PEDIATR, V29, P338, DOI 10.1097/DBP.0b013e318182a99e
Kohyama Jun, 2007, Neuropsychiatr Dis Treat, V3, P959
Krishna J, 2006, PAEDIATR RESPIR REV, V7, pS202, DOI 10.1016/j.prrv.2006.04.201
Kushida CA, 2001, SLEEP MED, V2, P389, DOI 10.1016/S1389-9457(00)00098-8
Landau R, 2010, INFANT MENT HEALTH J, V31, P630, DOI 10.1002/imhj.20275
Larkin EK, 2005, CIRCULATION, V111, P1978, DOI 10.1161/01.CIR.0000161819.76138.5E
LAVIE P, 1993, J SLEEP RES, V2, P34
Leitner Y, 2002, J CHILD NEUROL, V17, P872, DOI 10.1177/08830738020170121901
Lewandowski AS, 2010, PAIN, V151, P220, DOI 10.1016/j.pain.2010.07.016
MacLaren JE, 2008, J PEDIATR PSYCHOL, V33, P248, DOI 10.1093/jpepsy/jsm073
BLAND JM, 1986, LANCET, V1, P307
McArthur AJ, 1998, DEV MED CHILD NEUROL, V40, P186
Mello L., 2001, SLEEP HYPNOSIS, V3, P106
Meltzer LJ, 2012, SLEEP, V35, P159, DOI 10.5665/sleep.1608
Mennella JA, 2001, ALCOHOL, V25, P153, DOI 10.1016/S0741-8329(01)00175-6
Mennella JA, 2007, PEDIATRICS, V120, P497, DOI 10.1542/peds.2007-0488
Mennella JA, 1998, PEDIATRICS, V101, DOI 10.1542/peds.101.5.e2
Milroy G, 2008, J PEDIATR PSYCHOL, V33, P242, DOI 10.1093/jpepsy/jsm099
Montgomery-Downs HE, 2006, SLEEP, V29, P1282
Moon EC, 2011, J PEDIATR PSYCHOL, V36, P47, DOI 10.1093/jpepsy/jsq057
Moore M, 2009, J PEDIATR PSYCHOL, V34, P1175, DOI 10.1093/jpepsy/jsp039
Morgenthaler T, 2007, SLEEP, V30, P519
Nishihara K, 2002, PHYSIOL BEHAV, V77, P91, DOI 10.1016/S0031-9384(02)00846-6
O'Driscoll DM, 2009, ARCH DIS CHILD
Ohayon MM, 2004, SLEEP, V27, P1255
Ohinata J, 2008, BRAIN DEV-JPN, V30, P329, DOI 10.1016/j.braindev.2007.10.004
Ohrstrom E, 2006, J ENVIRON PSYCHOL, V26, P116, DOI 10.1016/j.jenvp.2006.06.004
Okawa M, 1998, PSYCHIAT CLIN NEUROS, V52, P259, DOI 10.1111/j.1440-1819.1998.tb01063.x
OPHIRCOHEN M, 1993, SLEEP, V16, P428
Owens J, 2009, SLEEP MED, V10, P446, DOI 10.1016/j.sleep.2008.03.013
Oyane NMF, 2005, AUTISM, V9, P83, DOI 10.1177/1362361305049031
Paavonen EJ, 2009, PEDIATRICS, V123, pE857, DOI 10.1542/peds.2008-2164
Paavonen EJ, 2002, SLEEP, V25, P235
Paavonen EJ, 2003, J CHILD ADOL PSYCHOP, V13, P83, DOI 10.1089/104454603321666225
Paavonen EJ, 2010, SLEEP MED, V11, P386, DOI 10.1016/j.sleep.2009.09.009
Palermo TM, 2008, BEHAV SLEEP MED, V6, P234, DOI 10.1080/15402000802371353
Palermo TM, 2007, CLIN J PAIN, V23, P812
Peixoto CAT, 2009, BEHAV SLEEP MED, V7, P73, DOI 10.1080/15402000902762311
Perfect MM, 2010, STRESS HEALTH, V26, P61, DOI 10.1002/smi.1262
Pesonen AK, 2009, SLEEP, V32, P1086
Pesonen AK, 2009, INT J BEHAV MED, V17, P298
Pillar G, 2000, PEDIATR NEUROL, V23, P225, DOI 10.1016/S0887-8994(00)00161-2
Pollak CP, 2001, SLEEP, V24, P957
Radan I, 2004, ACTA DIABETOL, V41, P33, DOI 10.1007/s00592-004-0141-3
Raikkonen K, 2010, J CLIN ENDOCR METAB, V95, P2254, DOI 10.1210/jc.2009-0943
Ravid S, 2009, J CHILD NEUROL, V24, P816, DOI 10.1177/0883073808330766
Ravid S, 2009, DEV NEUROPSYCHOL, V34, P574, DOI 10.1080/87565640903133533
Reed HE, 2009, J CHILD NEUROL, V24, P936, DOI 10.1177/0883073808331348
Reinberg A, 2002, CHRONOBIOL INT, V19, P1087, DOI 10.1081/CBI-120015959
Rivkees SA, 2010, BRIT J OPHTHALMOL, V94, P1358, DOI 10.1136/bjo.2009.175851
Roemmich JN, 2006, PEDIATRICS, V117, pE200, DOI 10.1154/peds.2005-1007
Rosen G, 2010, SUPPORT CARE CANCER, V19, P985
Ross KR, 2009, PEDIATR PULM, V44, P877, DOI 10.1002/ppul.21065
SADEH A, 1995, J AM ACAD CHILD PSY, V34, P813, DOI 10.1097/00004583-199506000-00023
Sadeh A, 2009, SLEEP, V32, P1602
Sadeh A, 2002, CHILD DEV, V73, P405, DOI 10.1111/1467-8624.00414
Sadeh A, 2011, SLEEP MED REV, V15, P259, DOI 10.1016/j.smrv.2010.10.001
SADEH A, 1995, INFANT BEHAV DEV, V18, P329, DOI 10.1016/0163-6383(95)90021-7
Sadeh A, 2000, DEV PSYCHOL, V36, P291, DOI 10.1037/0012-1649.36.3.291
SADEH A, 1994, SLEEP, V17, P201
SADEH A, 1991, PEDIATRICS, V87, P494
Sadeh A, 2002, SLEEP MED REV, V6, P113, DOI 10.1053/smrv.2001.0182
Sadeh A, 1996, SLEEP, V19, P757
SADEH A, 1994, J CONSULT CLIN PSYCH, V62, P63, DOI 10.1037//0022-006X.62.1.63
Sadeh A, 2007, J FAM PSYCHOL, V21, P74, DOI 10.1037/0893-3200.21.1.74
Sadeh A, 2004, PEDIATRICS, V113, pE570, DOI 10.1542/peds.113.6.e570
Sadeh A, 1998, SLEEP, V21, P379
Sanford SD, 2008, J PEDIATR PSYCHOL, V33, P298, DOI 10.1093/jpepsy/jsm110
Sangal RB, 2006, SLEEP, V29, P1573
Scher A, 1998, J CHILD PSYCHOL PSYC, V39, P785, DOI 10.1017/S0021963098002546
Scher A, 2001, DEV PSYCHOBIOL, V38, P274, DOI 10.1002/dev.1020
Scher A, 2004, INT J BEHAV DEV, V28, P268, DOI 10.1080/01650250344000505
Scher A, 2005, EARLY HUM DEV, V81, P289, DOI 10.1016/j.earlhumdev.2004.07.005
Scher A, 2010, DEV PSYCHOBIOL, V52, P44, DOI 10.1002/dev.20410
Schmitt B, 2009, EPILEPSIA, V50, P1860, DOI 10.1111/j.1528-1167.2009.02105.x
Schwartz G, 2004, J AM ACAD CHILD PSY, V43, P1276, DOI 10.1097/01.chi.0000135802.94090.93
Sitnick SL, 2008, SLEEP, V31, P395
Smits MG, 2001, J CHILD NEUROL, V16, P86, DOI 10.1177/088307380101600204
So K, 2005, PEDIATR RES, V58, P761, DOI 10.1203/01.PDR.0000180568.97221.56
So K, 2007, J SLEEP RES, V16, P181, DOI 10.1111/j.1365-2869.2007.00582.x
Souders MC, 2009, SLEEP, V32, P1566
Spruyt K, 2008, EARLY HUM DEV, V84, P289, DOI 10.1016/j.earlhumdev.2007.07.002
Steenari MR, 2003, J AM ACAD CHILD PSY, V42, P85, DOI 10.1097/01.CHI.0000024911.60748.D3
Stein MA, 1996, PEDIATRICS, V98, P748
Stremler R, 2006, SLEEP, V29, P1609
Sung M, 2009, ACTA PAEDIATR, V98, P52, DOI 10.1111/j.1651-2227.2008.01002.x
Suratt PM, 2007, PEDIATRICS, V119, P320, DOI 10.1542/peds.2006-1969
Teixeira L, 2010, INT J OCCUP ENV HEAL, V16, P172
Teixeira LR, 2004, CHRONOBIOL INT, V21, P845, DOI 10.1081/LCBI-200036878
Teixeira LR, 2007, CHRONOBIOL INT, V24, P99, DOI 10.1080/07420520601139763
Teixeira LR, 2004, CHRONOBIOL INT, V21, P239, DOI 10.1081/CBI-120037808
Thackeray EJ, 2002, BEHAV INTERVENT, V17, P211, DOI 10.1002/bin.123
Thomas Karen A, 2008, J Nurs Meas, V16, P201, DOI 10.1891/1061-3749.16.3.201
Tikotzky L, 2009, J SLEEP RES, V19, P103
Tikotzky L, 2009, CHILD DEV, V80, P860, DOI 10.1111/j.1467-8624.2009.01302.x
Tikotzky L, 2001, J CLIN CHILD PSYCHOL, V30, P581, DOI 10.1207/S15374424JCCP3004_13
Tikotzlcy L, 2010, J PEDIATR PSYCHOL, V36, P36
Tilmanne J, 2009, J SLEEP RES, V18, P85, DOI 10.1111/j.1365-2869.2008.00706.x
Tininenko JR, 2010, CHILD PSYCHIAT HUM D, V41, P409, DOI 10.1007/s10578-010-0177-2
Tininenko JR, 2011, J DEV BEHAV PEDIATR, V31, P668
Tremaine RB, 2010, SLEEP BIOL RHYTHMS, V8, P194, DOI 10.1111/j.1479-8425.2010.00446.x
Tremaine RB, 2010, SLEEP BIOL RHYTHMS, V8, P229, DOI 10.1111/j.1479-8425.2010.00452.x
Tsai SY, 2009, INFANT BEHAV DEV, V32, P340, DOI 10.1016/j.infbeh.2009.02.002
Tsai SY, 2008, J PEDIATR PSYCHOL, V33, P307, DOI 10.1093/jpepsy/jsm117
TZISCHINSKY O, 1991, CHRONOBIOL INT, V8, P168, DOI 10.3109/07420529109063923
Tzischinsky O, 2006, J PAEDIATR CHILD H, V42, P688, DOI 10.1111/j.1440-1754.2006.00952.x
Uberos J, 2011, J PINEAL RES, V50, P192, DOI 10.1111/j.1600-079X.2010.00828.x
Urner M, 2009, CHRONOBIOL INT, V26, P1222, DOI [10.3109/07420520903244600, 10.1080/07420520903244600]
Ustinov Y, 2011, SLEEP, V34, pA330
Vallance K, 2010, EUR J CANCER, V46, P1848, DOI 10.1016/j.ejca.2010.03.026
Van GI, 2010, PSYCHOPHARMACOLOGY B, V212, P379
van der Heijden K, 2005, BIOL RHYTHM RES, V36, P381, DOI 10.1080/09291010500218449
Van der Heijden KB, 2005, CHRONOBIOL INT, V22, P559, DOI 10.1081/CBI-200062410
Van der Heijden KB, 2006, J SLEEP RES, V15, P55
Van Der Heijden KB, 2007, J AM ACAD CHILD PSY, V46, P233, DOI 10.1097/01.chi.0000246055.76167.0d
Van der Heijden KB, 2005, J SLEEP RES, V14, P187
Wall SP, 2003, J SPORT REHABIL, V12, P1
Ward TM, 2008, J PEDIATR PSYCHOL, V33, P666, DOI 10.1093/jpepsy/jsm102
Ward TM, 2008, BIOL RES NURS, V9, P244, DOI 10.1177/1099800407310158
Wasdell MB, 2008, J PINEAL RES, V44, P57, DOI 10.1111/j.1600-079X.2007.00528.x
Webb EA, 2010, J CLIN ENDOCR METAB, V95, pE198, DOI 10.1210/jc.2010-0027
Wee R, 2004, OPHTHALMOLOGY, V111, P297, DOI 10.1016/j.ophtha.2003.05.014
Weiss A, 2010, SLEEP, V33, P1201
Weiss AR, 2010, J CLIN SLEEP MED, V6, P336
Werner H, 2008, ARCH PEDIAT ADOL MED, V162, P350, DOI 10.1001/archpedi.162.4.350
Werner H, 2009, CHRONOBIOL INT, V26, P992, DOI 10.1080/07420520903044505
Wiggins Shirley A, 2009, Issues Compr Pediatr Nurs, V32, P160, DOI 10.3109/01460860903281341
Wiggs L, 2004, DEV MED CHILD NEUROL, V46, P372
Wiggs L, 2005, SLEEP, V28, P1437
Wirojanan J, 2009, J CLIN SLEEP MED, V5, P145
Wolfson AR, 2003, SLEEP, V26, P213
Wulff K, 2001, BIOL RHYTHM RES, V32, P529, DOI 10.1076/brhm.32.5.529.1295
Yaron M, 2004, HIGH ALT MED BIOL, V5, P314, DOI 10.1089/ham.2004.5.314
Yetman RJ, 1996, BLOOD PRESS MONIT, V1, P111
Yuksel H, 2009, ANN ALLERG ASTHMA IM, V103, P290, DOI 10.1016/S1081-1206(10)60527-3
NR 244
TC 30
Z9 31
PU W B SAUNDERS CO LTD
PI LONDON
PA 32 JAMESTOWN RD, LONDON NW1 7BY, ENGLAND
SN 1087-0792
J9 SLEEP MED REV
JI Sleep Med. Rev.
PD OCT
PY 2012
VL 16
IS 5
BP 463
EP 475
DI 10.1016/j.smrv.2011.10.002
PG 13
WC Clinical Neurology; Neurosciences
SC Neurosciences & Neurology
GA 005UX
UT WOS:000308776700007
PM 22424706
ER
PT J
AU De-la-Iglesia, M
Olivar, JS
AF De-la-Iglesia, Myriam
Olivar, Jose-Sixto
TI Revision of studies and researches related with diagnostic comorbidity
of Autism Spectrum Disorder-High Functioning and anxiety disorders.
SO ANALES DE PSICOLOGIA
LA Spanish
DT Article
DE Autism Spectrum Disorder; High Functioning Autism; Asperger's Disorder;
Comorbidity; Anxiety
ID OBSESSIVE-COMPULSIVE DISORDER; PERVASIVE DEVELOPMENTAL DISORDERS;
ASPERGER-SYNDROME; PSYCHIATRIC-DISORDERS; REPETITIVE BEHAVIORS; SOCIAL
ANXIETY; YOUNG-PEOPLE; CHILDREN; ADOLESCENTS; SYMPTOMS
AB The aim of this study is to review the state of the art of research on comorbidity of Autism Spectrum Disorder-High Functioning (ASD-AF) and anxiety disorders with a threefold purpose: a) to analyse the methodological problems of research studies, b) to present hypothesis on comorbidity, adopting an approach taking into account the new proposal of DSM-V (APA, 2011), and c) to suggest future research lines. Our study concludes that there is an urgent need to develop specific strategies and instruments that help the differential assessment of comorbidity symptomatology and that favour proposals of more efficient treatments. An outstanding lack of research studies on this topic in spanish-speaking countries is highlighted.
C1 [De-la-Iglesia, Myriam] Univ Valladolid, Fac Educ & Trabajo Social, Dept Psicol, E-47011 Valladolid, Spain.
RP De-la-Iglesia, M (reprint author), Univ Valladolid, Fac Educ & Trabajo Social, Dept Psicol, Campus Miguel Delibes,Paseo Belen 1, E-47011 Valladolid, Spain.
EM mdelaig@psi.uva.es
RI WARD, Rick/H-7338-2012
CR Abramson RK, 2005, CHILD PSYCHIAT HUM D, V36, P155, DOI 10.1007/s10578-005-2973-7
Amaral DG, 2003, GENES BRAIN BEHAV, V2, P295, DOI 10.1034/j.1601-183X.2003.00043.x
APTER A, 1991, CLIN EXPT PSYCHIAT M, V4, P215
Asociacion Americana de Psiquiatria, 2011, DSM 5 DEV
Asociacion Americana de Psiquiatria, 2002, MAN DIAGN EST TRAST
Asperger H, 1944, ARCH PSYCHIAT NERVEN, V117, P76, DOI 10.1007/BF01837709
Attwood T., 2000, AUTISM, V4, P85, DOI DOI 10.1177/1362361300004001006
BARONCOHEN S, 1989, BRIT J DEV PSYCHOL, V7, P113
Bartz JA, 2006, PROG NEURO-PSYCHOPH, V30, P338, DOI 10.1016/j.pnpbp.2005.11.003
Bauminger N, 2000, CHILD DEV, V71, P447, DOI 10.1111/1467-8624.00156
Bejerot S, 2001, NORD J PSYCHIAT, V55, P169
Bejerot S, 2007, AUTISM, V11, P101, DOI 10.1177/1362361307075699
Bellini S., 2004, FOCUS AUTISM OTHER D, V19, P78, DOI DOI 10.1177/10883576040190020201
BISHOP DVM, 1989, BRIT J DISORD COMMUN, V24, P107
Brereton AV, 2006, J AUTISM DEV DISORD, V36, P863, DOI 10.1007/s10803-006-0125-y
Bryson S. E., 2000, AUTISM, V4, P117, DOI DOI 10.1177/1362361300004002002
CAPPS L, 1992, J CHILD PSYCHOL PSYC, V33, P1169, DOI 10.1111/j.1469-7610.1992.tb00936.x
CARON C, 1991, J CHILD PSYCHOL PSYC, V32, P1063, DOI 10.1111/j.1469-7610.1991.tb00350.x
Cath DC, 2008, PSYCHOPATHOLOGY, V41, P101, DOI 10.1159/000111555
CharlopChristy MH, 1996, J AUTISM DEV DISORD, V26, P527, DOI 10.1007/BF02172274
Damian M., 1997, ANALES PSICOLOGIA, V13, P143
de Bruin EI, 2007, J AUTISM DEV DISORD, V37, P877, DOI 10.1007/s10803-006-0215-x
Evans DW, 2005, CHILD PSYCHIAT HUM D, V36, P3, DOI 10.1007/s10578-004-3619-x
Farrugia S., 2006, FOCUS AUTISM OTHER D, V21, P25, DOI DOI 10.1177/10883576060210010401
Frith U, 1991, AUTISM ASPERGER SYND, P37
Gadow KD, 2005, AUTISM, V9, P392, DOI 10.1177/1362361305056079
Gadow KD, 2004, J AUTISM DEV DISORD, V34, P379, DOI 10.1023/B:JADD.0000037415.21458.93
Geller DA, 2006, PSYCHIAT CLIN N AM, V29, P353, DOI 10.1016/j.psc.2006.02.012
Ghaziuddin M, 2002, J AUTISM DEV DISORD, V32, P299, DOI 10.1023/A:1016330802348
Ghaziuddin M., 2002, FOCUS AUTISM OTHER D, V17, P138, DOI DOI 10.1177/10883576020170030301
Gillberg C, 2000, ACTA PSYCHIAT SCAND, V102, P321, DOI 10.1034/j.1600-0447.2000.102005321.x
Gillott A, 2001, AUTISM, V5, P277, DOI 10.1177/1362361301005003005
Green J, 2000, J AUTISM DEV DISORD, V30, P279, DOI 10.1023/A:1005523232106
Holguin JA, 2003, REV NEUROLOGIA, V37, P259
Hollander E, 2005, NEUROPSYCHOPHARMACOL, V30, P582, DOI 10.1038/sj.npp.1300627
Hollander E, 2003, PSYCHIAT RES, V117, P11, DOI 10.1016/S0165-1781(02)00304-9
Hutton J, 2008, AUTISM, V12, P373, DOI 10.1177/1362361308091650
Ivarsson T, 2008, J ANXIETY DISORD, V22, P969, DOI 10.1016/j.janxdis.2007.10.003
Kanner L, 1943, NERV CHILD, V2, P217
Khouzam H. R., 2004, COMPR PSYCHIAT, V45, P183
Klin A., 1997, HDB AUTISM PERVASIVE, P94
Lecavalier L, 2006, J AUTISM DEV DISORD, V36, P1101, DOI 10.1007/s10803-006-0147-5
Lehmkuhl H.D., 2007, J AUTISM DEV DISORD, V38, P977, DOI DOI 10.1007/S10803-007-0457-2
Leyfer OT, 2006, J AUTISM DEV DISORD, V36, P849, DOI 10.1007/s10803-006-0123-0
Lopez C, 2010, ANALES PSICOLOGIA, V26, P325
Martinez F, 1995, ANAL PSICOLOGIA, V11, P97
Matson JL, 2007, RES DEV DISABIL, V28, P341, DOI 10.1016/j.ridd.2005.12.004
Mazefsky CA, 2008, AUTISM RES, V1, P193, DOI 10.1002/aur.23
McDougle CJ, 2000, J AUTISM DEV DISORD, V30, P427, DOI 10.1023/A:1005551523657
Melfsen S, 2006, EUR CHILD ADOLES PSY, V15, P111, DOI 10.1007/s00787-006-0510-2
Myles BS, 2003, CHILD ADOL PSYCH CL, V12, P123, DOI 10.1016/S1056-4993(02)00048-2
Ollendick T. H., 2004, PHOBIAS, P245
Organizacion Mundial de la Salud, 2011, ICD UPD REV PLATF
Organizacion Mundial de la Salud, 1992, CLASS INT ENF CIE 10
Orgiles M, 2011, AN PSICOL-SPAIN, V27, P80
Paula-Perez I., 2009, REV NEUROL, V48, P31
Piacentini J, 2003, J CHILD ADOL PSYCHOP, V13, P61, DOI DOI 10.1089/104454603322126359
Piven J, 1999, AM J PSYCHIAT, V156, P557
Russell AJ, 2005, BRIT J PSYCHIAT, V186, P525, DOI 10.1192/bjp.186.6.525
Russell E, 2005, AUST NZ J PSYCHIAT, V39, P633, DOI 10.1080/j.1440-1614.2005.01637.x
Ruta D., 2010, EUROPEAN CHILD ADOLE, V91, P17
RUTTER M, 1994, J CHILD PSYCHOL PSYC, V35, P311, DOI 10.1111/j.1469-7610.1994.tb01164.x
Salavera C, 2010, UNIV PSYCHOL, V9, P457
Sanz J., 1993, ANAL PSICOLOGIA, V9, P133
Schopler E, 1983, AUTISM ADOLESCENTS A
Segui JD, 2008, AN PSICOL, V24, P100
Simonoff E, 2008, J AM ACAD CHILD PSY, V47, P921, DOI 10.1097/CHI.0b013e318179964f
SMALLEY SL, 1995, AM J MED GENET, V60, P19, DOI 10.1002/ajmg.1320600105
Spielberger C., 1970, MANUAL STATE TRAIT A
Sterling L, 2008, J AUTISM DEV DISORD, V38, P1011, DOI 10.1007/s10803-007-0477-y
Stewart ME, 2006, AUTISM, V10, P103, DOI 10.1177/1362361306062013
Sukhodolsky DG, 2008, J ABNORM CHILD PSYCH, V36, P117, DOI 10.1007/s10802-007-9165-9
Suria R., 2011, ANALES PSICOLOGIA, V27, P210
Sverd Jeffrey, 2003, J Psychiatr Pract, V9, P111, DOI 10.1097/00131746-200303000-00003
Tantam D., 2000, AUTISM INT J RES PRA, V4, P47, DOI DOI 10.1177/1362361300004001004
Tantam D, 2003, CHILD ADOL PSYCH CL, V12, P143, DOI 10.1016/S1056-4993(02)00053-6
Volkmar F. R., 2000, ASPERGER SYNDROME, P25
Weisbrot DM, 2005, J CHILD ADOL PSYCHOP, V15, P477, DOI 10.1089/cap.2005.15.477
White SW, 2009, CLIN PSYCHOL REV, V29, P216, DOI 10.1016/j.cpr.2009.01.003
White SW, 2009, J AUTISM DEV DISORD, V39, P1006, DOI 10.1007/s10803-009-0713-8
WING L, 1979, J AUTISM DEV DISORD, V9, P11, DOI 10.1007/BF01531288
WING L, 1981, PSYCHOL MED, V11, P115
Wolff S., 2000, ASPERGER SYNDROME, P278
Wolff S, 1998, ASPERGER SYNDROME HI, P123
Zandt F, 2007, J AUTISM DEV DISORD, V37, P251, DOI 10.1007/s10803-006-0158-2
NR 85
TC 0
Z9 0
PU UNIV MURCIA
PI MURCIA
PA SERVICIO DE PUBLICACIONES, CALLE VISTALEGRE S/N, MURCIA, 30007, SPAIN
SN 0212-9728
J9 AN PSICOL-SPAIN
JI An. Psicol.
PD OCT
PY 2012
VL 28
IS 3
BP 823
EP 833
DI 10.6018/analesps.28.3.124881
PG 11
WC Psychology; Psychology, Multidisciplinary
SC Psychology
GA 984QZ
UT WOS:000307207600020
ER
PT J
AU McAllister, AK
Patterson, PH
AF McAllister, A. Kimberley
Patterson, Paul H.
TI Introduction to special issue on neuroimmunology in brain development
and disease
SO DEVELOPMENTAL NEUROBIOLOGY
LA English
DT Editorial Material
ID SCHIZOPHRENIA; AUTISM
C1 [McAllister, A. Kimberley] Univ Calif Davis, Ctr Neurosci, Davis, CA 95616 USA.
[Patterson, Paul H.] CALTECH, Pasadena, CA 91125 USA.
RP McAllister, AK (reprint author), Univ Calif Davis, Ctr Neurosci, Davis, CA 95616 USA.
CR Bhat R, 2009, NEURON, V64, P123, DOI 10.1016/j.neuron.2009.09.015
Meyer U, 2011, PEDIATR RES, V69, p26R, DOI 10.1203/PDR.0b013e318212c196
Elmer BM, 2012, TRENDS NEUR IN PRESS
Garay Paula A, 2010, Front Synaptic Neurosci, V2, P136, DOI 10.3389/fnsyn.2010.00136
JOLY E, 1991, SCIENCE, V253, P1283, DOI 10.1126/science.1891717
Lucin KM, 2009, NEURON, V64, P110, DOI 10.1016/j.neuron.2009.08.039
McAllister AK, 2009, NEURON, V64, P9, DOI 10.1016/j.neuron.2009.09.038
Murphy JB, 1923, J EXP MED, V38, P183, DOI 10.1084/jem.38.2.183
Patterson PH, 2011, PEDIATR RES, V69, p34R, DOI 10.1203/PDR.0b013e318212b80f
Patterson PH, 2009, BEHAV BRAIN RES, V204, P313, DOI 10.1016/j.bbr.2008.12.016
Shatz CJ, 2009, NEURON, V64, P40, DOI 10.1016/j.neuron.2009.09.044
Stephan AH, 2012, ANNU REV NEUROSCI, V35, P369, DOI 10.1146/annurev-neuro-061010-113810
van den Pol AN, 2009, NEURON, V64, P17, DOI 10.1016/j.neuron.2009.09.023
NR 13
TC 3
Z9 3
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1932-8451
J9 DEV NEUROBIOL
JI Dev. Neurobiol.
PD OCT
PY 2012
VL 72
IS 10
SI SI
BP 1269
EP 1271
DI 10.1002/dneu.22054
PG 3
WC Developmental Biology; Neurosciences
SC Developmental Biology; Neurosciences & Neurology
GA 001NN
UT WOS:000308467500001
PM 22927111
ER
PT J
AU Brown, AS
AF Brown, Alan S.
TI Epidemiologic studies of exposure to prenatal infection and risk of
schizophrenia and autism
SO DEVELOPMENTAL NEUROBIOLOGY
LA English
DT Review
DE schizophrenia; infection; influenza; epidemiology; toxoplasmosis; birth
cohort
ID HERPES-SIMPLEX-VIRUS; ADULT SCHIZOPHRENIA; MATERNAL EXPOSURE; SPECTRUM
DISORDERS; REPRODUCTIVE INFECTIONS; IMMUNE ACTIVATION; COMMON VARIANTS;
BIRTH COHORT; ASSOCIATION; PREGNANCY
AB In this review, we provide a synopsis of work on the epidemiologic evidence for prenatal infection in the etiology of schizophrenia and autism. In birth cohort studies conducted by our group and others, in utero exposure to infectious agents, prospectively obtained after biomarker assays of archived maternal sera and by obstetric records was related to an increased risk of schizophrenia. Thus far, it has been demonstrated that prenatal exposure to influenza, increased toxoplasma antibody, genitalreproductive infections, rubella, and other pathogens are associated with schizophrenia. Anomalies of the immune system, including enhanced maternal cytokine levels, are also related to schizophrenia. Some evidence also suggests that maternal infection and immune dysfunction may be associated with autism. Although replication is required, these findings suggest that public health interventions targeting infectious exposures have the potential for preventing cases of schizophrenia and autism. Moreover, this work has stimulated translational research on the neurobiological and genetic determinants of these conditions. (c) 2012 Wiley Periodicals, Inc. Develop Neurobiol, 2012
C1 Columbia Univ, Coll Phys & Surg, New York State Psychiat Inst, New York, NY 10027 USA.
RP Brown, AS (reprint author), Columbia Univ, Coll Phys & Surg, New York State Psychiat Inst, New York, NY 10027 USA.
EM asb11@columbia.edu
FU National Institute of Mental Health (NIMH) [2K02-MH065422]; National
Institute of Environmental Health Sciences (NIEHS) [5R01ES019004-02];
National Alliance for Research on Schizophrenia and Depression (NARSAD)
Independent Investigator Award
FX Contract grant sponsor: National Institute of Mental Health (NIMH);
contract grant number: 2K02-MH065422 (A.S.B).Contract grant sponsor:
National Institute of Environmental Health Sciences (NIEHS); contract
grant number: 5R01ES019004-02.Contract grant sponsor: National Alliance
for Research on Schizophrenia and Depression (NARSAD) Independent
Investigator Award (A.S.B).
CR Abdallah MW, WORLD J BIO IN PRESS
Atladottir HO, 2010, J AUTISM DEV DISORD, V40, P1423, DOI 10.1007/s10803-010-1006-y
Babulas V, 2006, AM J PSYCHIAT, V163, P927, DOI 10.1176/appi.ajp.163.5.927
Boulanger LM, 2009, NEURON, V64, P93, DOI 10.1016/j.neuron.2009.09.001
Brown AS, 2009, AM J PSYCHIAT, V166, P683, DOI 10.1176/appi.ajp.2008.08010089
Brown AS, 2010, AM J PSYCHIAT, V167, P261, DOI 10.1176/appi.ajp.2009.09030361
Brown AS, 2009, SCHIZOPHR RES, V108, P285, DOI 10.1016/j.schres.2008.11.018
Brown AS, 2006, AM J PSYCHIAT, V163, P2178, DOI 10.1176/appi.ajp.163.12.2178
Brown AS, 2011, PSYCHIAT RES, V188, P179, DOI 10.1016/j.psychres.2011.04.020
Brown AS, 2001, BIOL PSYCHIAT, V49, P473, DOI 10.1016/S0006-3223(01)01068-X
Brown AS, 2004, ARCH GEN PSYCHIAT, V61, P774, DOI 10.1001/archpsyc.61.8.774
Brown AS, 2004, AM J PSYCHIAT, V161, P889, DOI 10.1176/appi.ajp.161.5.889
Brown AS, 2005, AM J PSYCHIAT, V162, P767, DOI 10.1176/appi.ajp.162.4.767
Brown AS, 2000, SCHIZOPHRENIA BULL, V26, P287
Buka SL, 2001, ARCH GEN PSYCHIAT, V58, P1032, DOI 10.1001/archpsyc.58.11.1032
Buka SL, 2008, BIOL PSYCHIAT, V63, P809, DOI 10.1016/j.biopsych.2007.09.022
Clarke MC, 2009, AM J PSYCHIAT, V166, P1025, DOI 10.1176/appi.ajp.2009.08010031
Fatemi SH, 2002, CELL MOL NEUROBIOL, V22, P25, DOI 10.1023/A:1015337611258
Glynn MW, 2011, NAT NEUROSCI, V14, P442, DOI 10.1038/nn.2764
Goines PE, 2011, MOL AUTISM, V2, DOI 10.1186/2040-2392-2-13
Grether JK, 2010, AUTISM RES, V3, P323, DOI 10.1002/aur.160
Hallmayer J, 2011, ARCH GEN PSYCHIAT, V68, P1095, DOI 10.1001/archgenpsychiatry.2011.76
Meyer U, 2009, NEUROSCI BIOBEHAV R, V33, P1061, DOI 10.1016/j.neubiorev.2009.05.001
Mortensen PB, 2010, SCHIZOPHR RES, V122, P257, DOI 10.1016/j.schres.2010.06.010
Mortensen Preben Bo, 2007, Biol Psychiatry, V61, P688, DOI 10.1016/j.biopsych.2006.05.024
Newschaffer CJ, 2002, EPIDEMIOL REV, V24, P137, DOI 10.1093/epirev.mxf010
Patterson PH, 2011, ORIGINS SCHIZOPHRENI, P255
Patterson PH, 2009, BEHAV BRAIN RES, V204, P313, DOI 10.1016/j.bbr.2008.12.016
Patterson PH, 2007, SCIENCE, V318, P576, DOI 10.1126/science.1150196
Purcell SM, 2009, NATURE, V460, P748, DOI 10.1038/nature08185
Riley BP, 2005, KAPLAN SADOCKS COMPR, P1354
Rothman K, 1998, MODERN EPIDEMIOLOGY, V2nd
Shi JX, 2009, NATURE, V460, P753, DOI 10.1038/nature08192
Shi LM, 2009, BRAIN BEHAV IMMUN, V23, P116, DOI 10.1016/j.bbi.2008.07.012
Sorensen HJ, 2009, SCHIZOPHRENIA BULL, V35, P631, DOI 10.1093/schbul/sbn121
Stefansson H, 2009, NATURE, V460, P744, DOI 10.1038/nature08186
Zuckerman L, 2003, NEUROPSYCHOPHARMACOL, V28, P1778, DOI 10.1038/sj.npp.1300248
NR 37
TC 46
Z9 46
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1932-8451
J9 DEV NEUROBIOL
JI Dev. Neurobiol.
PD OCT
PY 2012
VL 72
IS 10
SI SI
BP 1272
EP 1276
DI 10.1002/dneu.22024
PG 5
WC Developmental Biology; Neurosciences
SC Developmental Biology; Neurosciences & Neurology
GA 001NN
UT WOS:000308467500002
PM 22488761
ER
PT J
AU Michel, M
Schmidt, MJ
Mirnics, K
AF Michel, Maximilian
Schmidt, Martin J.
Mirnics, Karoly
TI Immune system gene dysregulation in autism and schizophrenia
SO DEVELOPMENTAL NEUROBIOLOGY
LA English
DT Review
DE schizophrenia; autism; immune; environment; maternal immune activation
ID GENOME-WIDE ASSOCIATION; PLACEBO-CONTROLLED TRIAL; FETAL-BRAIN
DEVELOPMENT; GLIAL TNF-ALPHA; SPECTRUM DISORDERS; PRENATAL INFECTION;
MONOZYGOTIC TWINS; COMMON VARIANTS; ANIMAL-MODELS; DOUBLE-BLIND
AB Gene*environment interactions play critical roles in the emergence of autism and schizophrenia pathophysiology. In both disorders, recent genetic association studies have provided evidence for disease-linked variation in immune system genes and postmortem gene expression studies have shown extensive chronic immune abnormalities in brains of diseased subjects. Furthermore, peripheral biomarker studies revealed that both innate and adaptive immune systems are dysregulated. In both disorders symptoms of the disease correlate with the immune system dysfunction; yet, in autism this process appears to be chronic and sustained, while in schizophrenia it is exacerbated during acute episodes. Furthermore, since immune abnormalities endure into adulthood and anti-inflammatory agents appear to be beneficial, it is likely that these immune changes actively contribute to disease symptoms. Modeling these changes in animals provided further evidence that prenatal maternal immune activation alters neurodevelopment and leads to behavioral changes that are relevant for autism and schizophrenia. The converging evidence strongly argues that neurodevelopmental immune insults and genetic background critically interact and result in increased risk for either autism or schizophrenia. Further research in these areas may improve prenatal health screening in genetically at-risk families and may also lead to new preventive and/or therapeutic strategies. (c) 2012 Wiley Periodicals, Inc. Develop Neurobiol, 2012
C1 [Michel, Maximilian; Schmidt, Martin J.; Mirnics, Karoly] Vanderbilt Univ, Dept Psychiat, Nashville, TN 37203 USA.
[Mirnics, Karoly] Vanderbilt Univ, Kennedy Ctr Res Human Dev, Nashville, TN USA.
RP Mirnics, K (reprint author), Vanderbilt Univ, Dept Psychiat, Nashville, TN 37203 USA.
EM karoly.mirnics@vanderbilt.edu
RI Mirnics, Karoly/E-6730-2010; Michel, Maximilian/A-8079-2012
OI Mirnics, Karoly/0000-0002-5521-0254;
FU Vanderbilt Brain Institute Scholars Award; NIH [R01 MH067234, R01
MH079299]
FX Training support for Martin J. Schmidt was provided by a Vanderbilt
Brain Institute Scholars Award.Contract grant sponsor: NIH; contract
grant numbers: R01 MH067234, R01 MH079299.
CR Abazyan B, 2010, BIOL PSYCHIAT, V68, P1172, DOI 10.1016/j.biopsych.2010.09.022
Abdallah MW, WORLD J BIO IN PRESS
Almoguera B, 2011, BMC MED GENET, V12, DOI 10.1186/1471-2350-12-81
Anney R, 2010, HUM MOL GENET, V19, P4072, DOI 10.1093/hmg/ddq307
Arion D, 2007, BIOL PSYCHIAT, V62, P711, DOI 10.1016/j.biopsych.2006.12.021
Ashwood P, 2011, BRAIN BEHAV IMMUN, V25, P40, DOI 10.1016/j.bbi.2010.08.003
Ashwood P, 2008, J NEUROIMMUNOL, V204, P149, DOI 10.1016/j.jneuroim.2008.07.006
Athanasiu L, 2010, J PSYCHIATR RES, V44, P748, DOI 10.1016/j.jpsychires.2010.02.002
Baranzini SE, 2009, CURR OPIN IMMUNOL, V21, P596, DOI 10.1016/j.coi.2009.09.014
Beattie EC, 2002, SCIENCE, V295, P2282, DOI 10.1126/science.1067859
Ben Achour S, 2010, Neurochem Int, V57, P440, DOI 10.1016/j.neuint.2010.02.013
Bernstein Hans-Gert, 2009, Expert Rev Neurother, V9, P1059, DOI 10.1586/ern.09.59
Boksa P, 2010, BRAIN BEHAV IMMUN, V24, P881, DOI 10.1016/j.bbi.2010.03.005
Bowen KK, 2011, NEUROREPORT, V22, P126, DOI 10.1097/WNR.0b013e3283430a44
Brown AS, 2010, AM J PSYCHIAT, V167, P261, DOI 10.1176/appi.ajp.2009.09030361
Brown AS, 2011, PROG NEUROBIOL, V93, P23, DOI 10.1016/j.pneurobio.2010.09.003
Brown AS, 2004, AM J PSYCHIAT, V161, P889, DOI 10.1176/appi.ajp.161.5.889
Buxhoeveden DP, 2006, NEUROPATH APPL NEURO, V32, P483, DOI 10.1111/j.1365-2990.2006.00745.x
Casanova MF, 2006, ACTA NEUROPATHOL, V112, P287, DOI 10.1007/s00401-006-0085-5
Chan MK, 2011, INT REV NEUROBIOL, V101, P95, DOI 10.1016/B978-0-12-387718-5.00005-5
Chen R, 2012, CELL, V148, P1293, DOI 10.1016/j.cell.2012.02.009
Chen X, 2007, MOL PSYCHIATR, V12, P273, DOI 10.1038/sj.mp.4001932
CHESS S, 1971, J AUTISM CHILD SCHIZ, V1, P33, DOI 10.1007/BF01537741
Chiavetto LB, 2002, BIOL PSYCHIAT, V51, P480, DOI 10.1016/S0006-3223(01)01324-5
Chung W. S., 2011, CURR OPIN NEUROBIOL, V22, P438
Crespi BJ, 2011, GENES BRAIN BEHAV, V10, P689, DOI 10.1111/j.1601-183X.2011.00710.x
Curran LK, 2007, PEDIATRICS, V120, pE1386, DOI 10.1542/peds.2007-0360
Meyer U, 2011, PEDIATR RES, V69, p26R, DOI 10.1203/PDR.0b013e318212c196
DAVIS JO, 1995, SCHIZOPHRENIA BULL, V21, P357
Deverman BE, 2009, NEURON, V64, P61, DOI 10.1016/j.neuron.2009.09.002
Devine JM, 2009, PM&R, V1, P560, DOI 10.1016/j.pmrj.2009.03.015
Drexhage RC, 2010, INT J NEUROPSYCHOPH, V13, P1369, DOI 10.1017/S1461145710000799
Drzyzga L, 2006, BRAIN BEHAV IMMUN, V20, P532, DOI 10.1016/j.bbi.2006.02.002
Ekdahl CT, 2012, FRONT PHARMACOL, V3, DOI 10.3389/fphar.2012.00041
Faludi Gábor, 2011, Int J Dev Neurosci, V29, P305, DOI 10.1016/j.ijdevneu.2011.02.013
Fatemi SH, 2009, SCHIZOPHR RES, V112, P46, DOI 10.1016/j.schres.2009.04.014
Fatemi SH, 2012, NEUROPHARMACOLOGY, V62, P1290, DOI 10.1016/j.neuropharm.2011.01.011
Fatemi SH, 2009, EUR NEUROPSYCHOPHARM, V19, P648, DOI 10.1016/j.euroneuro.2009.03.004
Frangou S, 2000, SCHIZOPHRENIA
Garbett K, 2008, NEUROBIOL DIS, V30, P303, DOI 10.1016/j.nbd.2008.01.012
Garbett Krassimira, 2008, Neuropsychopharmacol Hung, V10, P9
Garbett K, TRANSLATION IN PRESS
Gauthier J, 2011, HUM GENET, V130, P563, DOI 10.1007/s00439-011-0975-z
Geschwind DH, 2009, ANNU REV MED, V60, P367, DOI 10.1146/annurev.med.60.053107.121225
Goines PE, 2011, MOL AUTISM, V2, DOI 10.1186/2040-2392-2-13
Golan HM, 2005, NEUROPHARMACOLOGY, V48, P903, DOI 10.1016/j.neuropharm.2004.12.023
Guerini FR, 2011, J NEUROIMMUNOL, V230, P135, DOI 10.1016/j.jneuroim.2010.10.019
Guerini FR, 2009, HUM IMMUNOL, V70, P184, DOI 10.1016/j.humimm.2008.12.009
Hallmayer J, 2011, ARCH GEN PSYCHIAT, V68, P1095, DOI 10.1001/archgenpsychiatry.2011.76
Hashimoto R, 2011, NEUROPSYCHOPHARMACOL, V36, P1921, DOI 10.1038/npp.2011.78
Hu VW, 2006, BMC GENOMICS, V7, DOI 10.1186/1471-2164-7-118
Hu VW, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0005775
Katsel P, 2005, SCHIZOPHR RES, V79, P157, DOI 10.1016/j.schres.2005.06.007
Kneeland R.E., 2012, PROG NEUROPSYCHOPHAR
Kurian SM, 2011, MOL PSYCHIATR, V16, P37, DOI 10.1038/mp.2009.117
Laan W, 2010, J CLIN PSYCHIAT, V71, P520, DOI 10.4088/JCP.09m05117yel
Lazarov O, 2005, CELL, V120, P701, DOI 10.1016/j.cell.2005.01.015
Lee LC, 2006, PEDIATR NEUROL, V35, P303, DOI 10.1016/j.pediatrneurol.2006.06.006
Lee RH, 2010, NEURAL DEV, V5, DOI 10.1186/1749-8104-5-2
Lintas C, 2012, NEUROBIOL DIS, V45, P57, DOI 10.1016/j.nbd.2010.11.010
Ma DQ, 2009, ANN HUM GENET, V73, P263, DOI 10.1111/j.1469-1809.2009.00523.x
Ma X, 2011, GENES BRAIN BEHAV, V10, P734, DOI 10.1111/j.1601-183X.2011.00712.x
Markram Henry, 2007, Front Neurosci, V1, P77, DOI 10.3389/neuro.01.1.1.006.2007
Meyer U, 2010, SCHIZOPHRENIA BULL, V36, P607, DOI 10.1093/schbul/sbn131
Meyer U, 2007, NEUROSCIENTIST, V13, P241, DOI 10.1177/1073858406296401
Meyer U, 2006, J NEUROSCI, V26, P4752, DOI 10.1523/JNEUROSCI.0099-06.2006
Meyer U, PROG NEUROP IN PRESS
Miller BJ, 2011, BIOL PSYCHIAT, V70, P663, DOI 10.1016/j.biopsych.2011.04.013
Mirnics K, 2008, NAT NEUROSCI, V11, P1237, DOI 10.1038/nn1108-1237
Mitchell AC, 2012, OBESITY, V20, P692, DOI 10.1038/oby.2011.328
Monji A, PROG NEUROP IN PRESS
Muller N, 2002, AM J PSYCHIAT, V159, P1029, DOI 10.1176/appi.ajp.159.6.1029
Mueller Norbert, 2010, Current Immunology Reviews, V6, P213
Muller N, 2010, SCHIZOPHR RES, V121, P118, DOI 10.1016/j.schres.2010.04.015
Need AC, 2009, PLOS GENET, V5, DOI 10.1371/journal.pgen.1000373
Noterdaeme Michele, 2011, Klin Padiatr, V223 Suppl 1, pE1, DOI 10.1055/s-0030-1256068
O'Donovan MC, 2008, NAT GENET, V40, P1053, DOI 10.1038/ng.201
Oldham MC, 2008, NAT NEUROSCI, V11, P1271, DOI 10.1038/nn.2207
Onore C, 2012, BRAIN BEHAV IMMUN, V26, P383, DOI 10.1016/j.bbi.2011.08.007
Oskvig DB, 2012, BRAIN BEHAV IMMUN, V26, P623, DOI 10.1016/j.bbi.2012.01.015
Paolicelli RC, 2011, SCIENCE, V333, P1456, DOI 10.1126/science.1202529
Patterson PH, 2009, BEHAV BRAIN RES, V204, P313, DOI 10.1016/j.bbr.2008.12.016
Paul-Samojedny M, 2010, J MOL NEUROSCI, V42, P112, DOI 10.1007/s12031-010-9365-6
Piontkewitz Y, 2009, BIOL PSYCHIAT, V66, P1038, DOI 10.1016/j.biopsych.2009.07.005
Piontkewitz Y, 2011, SCHIZOPHRENIA BULL, V37, P1257, DOI 10.1093/schbul/sbq040
Purcell SM, 2009, NATURE, V460, P748, DOI 10.1038/nature08185
Radak Z, 2010, J ALZHEIMERS DIS, V20, P777, DOI 10.3233/JAD-2010-091531
Ratajczak HV, 2011, J IMMUNOTOXICOL, V8, P68, DOI 10.3109/1547691X.2010.545086
Raychaudhuri S, 2011, CELL, V147, P57, DOI 10.1016/j.cell.2011.09.011
Ripke S, 2011, NAT GENET, V43, P969, DOI 10.1038/ng.940
Rossignol DA, 2009, ANN CLIN PSYCHIATRY, V21, P213
Russell PJ, 2003, ESSENTIAL GENETICS
Saetre P, 2007, BMC PSYCHIATRY, V7, DOI 10.1186/1471-244X-7-46
Schmitt A, 2011, WORLD J BIOL PSYCHIA, V12, P201, DOI 10.3109/15622975.2010.530690
Schwarz MJ, 2006, EUR ARCH PSY CLIN N, V256, P72, DOI 10.1007/s00406-005-0603-9
Selten JP, 2010, SCHIZOPHRENIA BULL, V36, P219, DOI 10.1093/schbul/sbp147
Sequeira PA, 2012, NEUROBIOL DIS, V45, P23, DOI 10.1016/j.nbd.2011.03.001
Serantes R, 2006, J BIOL CHEM, V281, P14632, DOI 10.1074/jbc.M512489200
Shao L, 2008, BIOL PSYCHIAT, V64, P89, DOI 10.1016/j.biopsych.2007.11.010
Shatz CJ, 2009, NEURON, V64, P40, DOI 10.1016/j.neuron.2009.09.044
Shi JX, 2009, NATURE, V460, P753, DOI 10.1038/nature08192
Shi LM, 2005, INT J DEV NEUROSCI, V23, P299, DOI 10.1016/j.ijdevneu.2004.05.005
Shifman S, 2008, PLOS GENET, V4, DOI 10.1371/journal.pgen.0040028
Smith SEP, 2007, J NEUROSCI, V27, P10695, DOI 10.1523/JNEUROSCI.2178-07.2007
Song XQ, 2009, BIOL PSYCHIAT, V65, P481, DOI 10.1016/j.biopsych.2008.10.018
Stefansson H, 2009, NATURE, V460, P744, DOI 10.1038/nature08186
Stellwagen D, 2006, NATURE, V440, P1054, DOI 10.1038/nature04671
Strous RD, 2006, J AUTOIMMUN, V27, P71, DOI 10.1016/j.jaut.2006.07.006
Sullivan PF, 2008, MOL PSYCHIATR, V13, P570, DOI 10.1038/mp.2008.25
Sullivan PF, 2003, ARCH GEN PSYCHIAT, V60, P1187, DOI 10.1001/archpsyc.60.12.1187
Takahashi M, 2010, SCHIZOPHR RES, V119, P210, DOI 10.1016/j.schres.2009.12.024
Tandon R, 2008, SCHIZOPHR RES, V102, P1, DOI 10.1016/j.schres.2008.04.011
Tandon R, 2009, SCHIZOPHR RES, V110, P1, DOI 10.1016/j.schres.2009.03.005
Torres AR, 2006, HUM IMMUNOL, V67, P346, DOI 10.1016/j.humimm.2006.01.001
Traherne JA, 2008, INT J IMMUNOGENET, V35, P179, DOI 10.1111/j.1744-313X.2008.00765.x
Vargas DL, 2005, ANN NEUROL, V57, P67, DOI 10.1002/ana.20315
Voineagu I, 2011, NATURE, V474, P380, DOI 10.1038/nature10110
Vuillermot S, 2012, J NEUROSCI, V32, P436, DOI 10.1523/JNEUROSCI.4831-11.2012
Walsh T, 2008, SCIENCE, V320, P539, DOI 10.1126/science.1155174
Wang K, 2009, NATURE, V459, P528, DOI 10.1038/nature07999
Weiss LA, 2009, NATURE, V461, P802, DOI 10.1038/nature08490
Wucherpfennig KW, 2011, SEMIN IMMUNOL, V23, P84, DOI 10.1016/j.smim.2011.01.007
Yamada K, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0020468
Yue WH, 2011, NAT GENET, V43, P1228, DOI 10.1038/ng.979
Ziats MN, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0024691
Zigmond Michael J, 2009, Parkinsonism Relat Disord, V15 Suppl 3, pS42, DOI 10.1016/S1353-8020(09)70778-3
NR 126
TC 24
Z9 25
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1932-8451
J9 DEV NEUROBIOL
JI Dev. Neurobiol.
PD OCT
PY 2012
VL 72
IS 10
SI SI
BP 1277
EP 1287
DI 10.1002/dneu.22044
PG 11
WC Developmental Biology; Neurosciences
SC Developmental Biology; Neurosciences & Neurology
GA 001NN
UT WOS:000308467500003
PM 22753382
ER
PT J
AU Needleman, LA
McAllister, AK
AF Needleman, Leigh A.
McAllister, A. Kimberley
TI The major histocompatibility complex and autism spectrum disorder
SO DEVELOPMENTAL NEUROBIOLOGY
LA English
DT Review
DE maternal infection; neuroimmunology; genetics; synapse formation;
synaptic plasticity
ID MHC CLASS-I; CENTRAL-NERVOUS-SYSTEM; CONGENITAL
CYTOMEGALOVIRUS-INFECTION; OCULAR-DOMINANCE PLASTICITY; PRENATAL IMMUNE
CHALLENGE; PARENTAL HLA ANTIGENS; NECROSIS-FACTOR-ALPHA; GLIAL
TNF-ALPHA; SYNAPTIC PLASTICITY; GENE-EXPRESSION
AB Autism spectrum disorder (ASD) is a complex disorder that appears to be caused by interactions between genetic changes and environmental insults during early development. A wide range of factors have been linked to the onset of ASD, but recently both genetic associations and environmental factors point to a central role for immune-related genes and immune responses to environmental stimuli. Specifically, many of the proteins encoded by the major histocompatibility complex (MHC) play a vital role in the formation, refinement, maintenance, and plasticity of the brain. Manipulations of levels of MHC molecules have illustrated how disrupted MHC signaling can significantly alter brain connectivity and function. Thus, an emerging hypothesis in our field is that disruptions in MHC expression in the developing brain caused by mutations and/or immune dysregulation may contribute to the altered brain connectivity and function characteristic of ASD. This review provides an overview of the structure and function of the three classes of MHC molecules in the immune system, healthy brain, and their possible involvement in ASD. (c) 2012 Wiley Periodicals, Inc. Develop Neurobiol, 2012
C1 [Needleman, Leigh A.; McAllister, A. Kimberley] Univ Calif Davis, Ctr Neurosci, Davis, CA 95618 USA.
RP McAllister, AK (reprint author), Univ Calif Davis, Ctr Neurosci, Davis, CA 95618 USA.
EM kmcallister@ucdavis.edu
CR Abdallah MW, 2011, WORLD J BIOL PSYCHIA, DOI [10.3109/15622975.2011.639803, DOI 10.3109/15622975.2011.639803]
Abdallah MW, 2012, BRAIN BEHAV IMMUN, V26, P170, DOI 10.1016/j.bbi.2011.09.003
Albensi BC, 2000, SYNAPSE, V35, P151
Alfonso C, 2000, ANNU REV IMMUNOL, V18, P113, DOI 10.1146/annurev.immunol.18.1.113
Ashwood P, 2011, BRAIN BEHAV IMMUN, V25, P40, DOI 10.1016/j.bbi.2010.08.003
Ashwood P, 2008, J NEUROIMMUNOL, V204, P149, DOI 10.1016/j.jneuroim.2008.07.006
Ashwood P, 2011, J NEUROIMMUNOL, V232, P196, DOI 10.1016/j.jneuroim.2010.10.025
Ashwood P, 2008, J AUTISM DEV DISORD, V38, P169, DOI 10.1007/s10803-006-0353-1
Atladottir HO, 2010, J AUTISM DEV DISORD, V40, P1423, DOI 10.1007/s10803-010-1006-y
Bauer S, 2007, NAT REV NEUROSCI, V8, P221, DOI 10.1038/nrn2054
Beattie EC, 2002, SCIENCE, V295, P2282, DOI 10.1126/science.1067859
Bergen SE, 2012, MOL PSYCHIATR, V17, P880, DOI 10.1038/mp.2012.73
Bhat R, 2009, NEURON, V64, P123, DOI 10.1016/j.neuron.2009.09.015
Boulanger LM, 2004, NAT REV NEUROSCI, V5, P521, DOI 10.1038/nrn1428
Boulanger LM, 2009, NEURON, V64, P93, DOI 10.1016/j.neuron.2009.09.001
Brown AS, 2011, SCHIZOPHRENIA BULL, V37, P284, DOI 10.1093/schbul/sbq146
Brown AS, 2012, DEV NEUROBIOL, V72, P1272, DOI 10.1002/dneu.22024
Careaga M, 2010, NEUROTHERAPEUTICS, V7, P283, DOI 10.1016/j.nurt.2010.05.003
CHESS S, 1977, J AUTISM CHILD SCHIZ, V7, P69, DOI 10.1007/BF01531116
Chez MG, 2007, PEDIATR NEUROL, V36, P361, DOI 10.1016/j.pediatrneurol.2007.01.012
Corbett BA, 2007, MOL PSYCHIATR, V12, P292, DOI 10.1038/sj.mp.4001943
Corriveau RA, 1998, NEURON, V21, P505, DOI 10.1016/S0896-6273(00)80562-0
Meyer U, 2011, PEDIATR RES, V69, p26R, DOI 10.1203/PDR.0b013e318212c196
DANIELS WW, 1995, NEUROPSYCHOBIOLOGY, V32, P120, DOI 10.1159/000119223
Datwani A, 2009, NEURON, V64, P463, DOI 10.1016/j.neuron.2009.10.015
Davies BJ, 1998, J BIOL CHEM, V273, P23004, DOI 10.1074/jbc.273.36.23004
Deverman BE, 2009, NEURON, V64, P61, DOI 10.1016/j.neuron.2009.09.002
DEYKIN EY, 1979, AM J EPIDEMIOL, V109, P628
Enstrom AM, 2010, BRAIN BEHAV IMMUN, V24, P64, DOI 10.1016/j.bbi.2009.08.001
Enstrom AM, 2009, CURR OPIN INVEST DR, V10, P463
Fatemi SH, 1998, BRAIN RES, V800, P1, DOI 10.1016/S0006-8993(98)00450-8
Fatemi SH, 2002, MOL PSYCHIATR, V7, P633, DOI 10.1038/sj.mp.4001046
Ferrante P, 2003, BIOMED PHARMACOTHER, V57, P372, DOI 10.1016/S0753-3322(03)00099-4
Foster J, 1996, BRAIN RES, V724, P73, DOI 10.1016/0006-8993(96)00266-1
Fourgeaud L, 2010, EUR J NEUROSCI, V32, P207, DOI 10.1111/j.1460-9568.2010.07342.x
Fourgeaud L, 2010, P NATL ACAD SCI USA, V107, P22278, DOI 10.1073/pnas.0914064107
Garay Paula A, 2010, Front Synaptic Neurosci, V2, P136, DOI 10.3389/fnsyn.2010.00136
Gejman PV, 2011, ANNU REV GENOM HUM G, V12, P121, DOI 10.1146/annurev-genom-082410-101459
Geschwind DH, 2011, TRENDS COGN SCI, V15, P409, DOI 10.1016/j.tics.2011.07.003
Glynn MW, 2011, NAT NEUROSCI, V14, P442, DOI 10.1038/nn.2764
Goddard CA, 2007, P NATL ACAD SCI USA, V104, P6828, DOI 10.1073/pnas.0702023104
Goines PE, 2011, MOL AUTISM, V2, DOI 10.1186/2040-2392-2-13
Goldsmith CAW, 2008, PHARMACOTHERAPY, V28, P730, DOI 10.1592/phco.28.6.730
Guerini FR, 2011, J NEUROIMMUNOL, V230, P135, DOI 10.1016/j.jneuroim.2010.10.019
Guerini FR, 2006, HUM IMMUNOL, V67, P108, DOI 10.1016/j.humimm.2006.02.033
Guerini FR, 2009, HUM IMMUNOL, V70, P184, DOI 10.1016/j.humimm.2008.12.009
Haga S, 1996, NEUROSCI LETT, V216, P191, DOI 10.1016/0304-3940(96)13040-8
Hagberg H, 2012, ANN NEUROL, V71, P444, DOI 10.1002/ana.22620
Hallmayer J, 2011, ARCH GEN PSYCHIAT, V68, P1095, DOI 10.1001/archgenpsychiatry.2011.76
Hamshere ML, 2013, MOL PSYCHIATR, V18, P708, DOI 10.1038/mp.2012.67
Hsiao EY, 2011, BRAIN BEHAV IMMUN, V25, P604, DOI 10.1016/j.bbi.2010.12.017
Huh GS, 2000, SCIENCE, V290, P2155, DOI 10.1126/science.290.5499.2155
Janeway C. A., 2004, IMMUNOBIOLOGY
Jia PL, 2012, J MED GENET, V49, P96, DOI 10.1136/jmedgenet-2011-100397
Johnson WG, 2009, ARCH PEDIAT ADOL MED, V163, P542, DOI 10.1001/archpediatrics.2009.74
Kanner L, 1943, NERV CHILD, V2, P217
Kinney DK, 2008, NEUROSCI BIOBEHAV R, V32, P1519, DOI 10.1016/j.neubiorev.2008.06.004
Kipnis J, 2008, TRENDS IMMUNOL, V29, P455, DOI 10.1016/j.it.2008.07.007
Krzewski K, 2008, CURR OPIN CELL BIOL, V20, P597, DOI 10.1016/j.ceb.2008.05.006
Lee LC, 2006, PEDIATR NEUROL, V35, P303, DOI 10.1016/j.pediatrneurol.2006.06.006
Lee RH, 2010, NEURAL DEV, V5, DOI 10.1186/1749-8104-5-2
Li WX, 2008, TRENDS CELL BIOL, V18, P545, DOI 10.1016/j.tcb.2008.08.008
Libbey JE, 2005, J NEUROVIROL, V11, P1, DOI 10.1080/13550280590900553
Long EO, 2008, IMMUNOL REV, V224, P70, DOI 10.1111/j.1600-065X.2008.00660.x
LUBERNAROD J, 1988, NEUROSCI LETT, V94, P17, DOI 10.1016/0304-3940(88)90263-7
Machold RP, 1996, J EXP MED, V184, P2251, DOI 10.1084/jem.184.6.2251
Malkova NV, 2012, BRAIN BEHAV IMMUN, V26, P607, DOI 10.1016/j.bbi.2012.01.011
Manzardo AM, 2011, INT J DEV NEUROSCI, V30, P121
McAllister AK, 2009, NEURON, V64, P9, DOI 10.1016/j.neuron.2009.09.038
McConnell MJ, 2009, P NATL ACAD SCI USA, V106, P6784, DOI 10.1073/pnas.0902018106
Meraz MA, 1996, CELL, V84, P431, DOI 10.1016/S0092-8674(00)81288-X
Meyer U, 2008, BRAIN BEHAV IMMUN, V22, P469, DOI 10.1016/j.bbi.2007.09.012
Meyer U, 2010, PROG NEUROBIOL, V90, P285, DOI 10.1016/j.pneurobio.2009.10.018
Meyer U, 2006, J NEUROSCI, V26, P4752, DOI 10.1523/JNEUROSCI.0099-06.2006
Michel M, 2012, DEV NEUROBIOL, V72, P1277, DOI 10.1002/dneu.22044
Molloy CA, 2006, J NEUROIMMUNOL, V172, P198, DOI 10.1016/j.jneuroim.2005.11.007
Mostafa GA, 2010, J NEUROIMMUNOL, V223, P115, DOI 10.1016/j.jneuroim.2010.03.025
Needleman LA, 2010, P NATL ACAD SCI USA, V107, P16999, DOI 10.1073/pnas.1006087107
Neefjes J, 2011, NAT REV IMMUNOL, V11, P823, DOI 10.1038/nri3084
Neumann H, 1997, J EXP MED, V185, P305, DOI 10.1084/jem.185.2.305
Nordahl CW, 2011, P NATL ACAD SCI USA, V108, P20195, DOI 10.1073/pnas.1107560108
Odell D, 2005, HUM IMMUNOL, V66, P140, DOI 10.1016/j.humimm.2004.11.002
Onore C, 2009, J NEUROIMMUNOL, V216, P126, DOI 10.1016/j.jneuroim.2009.09.005
Onore C, 2011, BRAIN BEHAV IMMUN
Patterson PH, 2011, PEDIATR RES, V69, p34R, DOI 10.1203/PDR.0b013e318212b80f
Patterson PH, 2011, TRENDS MOL MED, V17, P389, DOI 10.1016/j.molmed.2011.03.001
Patterson PH, 2009, BEHAV BRAIN RES, V204, P313, DOI 10.1016/j.bbr.2008.12.016
PERLMUTTER LS, 1992, J NEUROSCI RES, V33, P549, DOI 10.1002/jnr.490330407
PEUDENIER S, 1991, RES VIROLOGY, V142, P145, DOI 10.1016/0923-2516(91)90051-4
PLIOPLYS AV, 1994, NEUROPSYCHOBIOLOGY, V29, P12, DOI 10.1159/000119056
Purcell SM, 2009, NATURE, V460, P748, DOI 10.1038/nature08185
Reichelt AC, 2012, NEUROPHARMACOLOGY, V62, P1519, DOI 10.1016/j.neuropharm.2011.01.024
Rezaie P, 1999, MICROSC RES TECHNIQ, V45, P359, DOI 10.1002/(SICI)1097-0029(19990615)45:6<359::AID-JEMT4>3.0.CO;2-D
Ribic A, 2010, CELL MOL NEUROBIOL, V30, P827, DOI 10.1007/s10571-010-9510-3
Rosenberg RE, 2009, ARCH PEDIAT ADOL MED, V163, P907, DOI 10.1001/archpediatrics.2009.98
Santos SG, 2004, J BIOL CHEM, V279, P53062, DOI 10.1074/jbc.M408794200
Schafer DP, 2010, BIOCHEM SOC T, V38, P476, DOI 10.1042/BST0380476
Schindler C, 2007, J BIOL CHEM, V282, P20059, DOI 10.1074/jbc.R700016200
Shatz CJ, 2009, NEURON, V64, P40, DOI 10.1016/j.neuron.2009.09.044
Shelton JF, 2010, AUTISM RES, V3, P30, DOI 10.1002/aur.116
Shi JX, 2009, NATURE, V460, P753, DOI 10.1038/nature08192
Shi LM, 2009, BRAIN BEHAV IMMUN, V23, P116, DOI 10.1016/j.bbi.2008.07.012
Shi LM, 2003, J NEUROSCI, V23, P297
Singh VK, 1997, PEDIATR NEUROL, V17, P88, DOI 10.1016/S0887-8994(97)00045-3
Smith SEP, 2007, J NEUROSCI, V27, P10695, DOI 10.1523/JNEUROSCI.2178-07.2007
Song WC, 2006, AUTOIMMUNITY, V39, P403, DOI 10.1080/08916930600739647
Spiliotis ET, 2002, MOL BIOL CELL, V13, P1566, DOI 10.1091/mbc.01-07-0322
Stefansson H, 2009, NATURE, V460, P744, DOI 10.1038/nature08186
Stellwagen D, 2006, NATURE, V440, P1054, DOI 10.1038/nature04671
Stellwagen D, 2011, ADV EXP MED BIOL, V691, P541, DOI 10.1007/978-1-4419-6612-4_57
Stellwagen D, 2005, J NEUROSCI, V25, P3219, DOI 10.1523/JNEUROSCI.4486-04.2005
Stetler RA, 2010, PROG NEUROBIOL, V92, P184, DOI 10.1016/j.pneurobio.2010.05.002
Stevens B, 2007, CELL, V131, P1164, DOI 10.1016/j.cell.2007.10.036
STUBBS EG, 1985, J AM ACAD CHILD PSY, V24, P182, DOI 10.1016/S0002-7138(09)60445-3
STUBBS EG, 1980, J AUTISM DEV DISORD, V10, P15, DOI 10.1007/BF02408429
STUBBS EG, 1978, J AUTISM CHILD SCHIZ, V8, P37, DOI 10.1007/BF01550276
STUBBS G, 1981, LANCET, V2, P534
Sweeten TL, 2004, J AUTISM DEV DISORD, V34, P583, DOI 10.1007/s10803-004-2552-y
Syken J, 2006, SCIENCE, V313, P1795, DOI 10.1126/science.1128232
Szatmari P, 2011, ARCH GEN PSYCHIAT, V68, P1091, DOI 10.1001/archgenpsychiatry.2011.99
Tancredi V, 2000, J NEUROCHEM, V75, P634, DOI 10.1046/j.1471-4159.2000.0750634.x
Thomas A, 2000, INT IMMUNOL, V12, P1015, DOI 10.1093/intimm/12.7.1015
Torres AR, 2002, HUM IMMUNOL, V63, P311, DOI 10.1016/S0198-8859(02)00374-9
Torres AR, 2006, HUM IMMUNOL, V67, P346, DOI 10.1016/j.humimm.2006.01.001
Traynor TR, 2004, LIFE SCI, V74, P2563, DOI 10.1016/j.lfs.2003.10.010
Turner T, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0026418
Turturici G., 2011, BIOCH RES INT, V2011
Vargas DL, 2005, ANN NEUROL, V57, P67, DOI 10.1002/ana.20315
Voineagu I, 2011, NATURE, V474, P380, DOI 10.1038/nature10110
Walker DG, 1998, BRAIN RES, V809, P31, DOI 10.1016/S0006-8993(98)00811-7
WARREN RP, 1994, ARCH PEDIAT ADOL MED, V148, P180
WARREN RP, 1992, IMMUNOGENETICS, V36, P203, DOI 10.1007/BF00215048
Warren RP, 1996, J NEUROIMMUNOL, V67, P97
WARREN RP, 1991, CLIN EXP IMMUNOL, V83, P438
WARREN RP, 1990, J AM ACAD CHILD PSY, V29, P873, DOI 10.1097/00004583-199011000-00005
Wierzba-Bobrowicz T, 2001, ADV EXP MED BIOL, V495, P93
WILLIAMS DB, 1989, J IMMUNOL, V142, P2796
Wingate M., 2012, MMWR SURVEILL SUMM, V61, P1
Xu HP, 2010, NEURON, V65, P503, DOI 10.1016/j.neuron.2010.01.035
Yamashita Y, 2003, J AUTISM DEV DISORD, V33, P455, DOI 10.1023/A:1025023131029
Yenari MA, 2002, ADV EXP MED BIOL, V513, P281
Zerbo O, 2011, EPIDEMIOLOGY, V22, P469, DOI 10.1097/EDE.0b013e31821d0b53
Zhou J, 2008, J NEUROCHEM, V106, P2080, DOI 10.1111/j.1471-4159.2008.05558.x
NR 143
TC 10
Z9 10
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1932-8451
J9 DEV NEUROBIOL
JI Dev. Neurobiol.
PD OCT
PY 2012
VL 72
IS 10
SI SI
BP 1288
EP 1301
DI 10.1002/dneu.22046
PG 14
WC Developmental Biology; Neurosciences
SC Developmental Biology; Neurosciences & Neurology
GA 001NN
UT WOS:000308467500004
PM 22760919
ER
PT J
AU Hsiao, EY
Patterson, PH
AF Hsiao, Elaine Y.
Patterson, Paul H.
TI Placental regulation of maternal-fetal interactions and brain
development
SO DEVELOPMENTAL NEUROBIOLOGY
LA English
DT Review
DE intrauterine; trophoblast; autism; schizophrenia; cerebral palsy
ID AUTISM SPECTRUM DISORDERS; HEMATOPOIETIC STEM-CELLS; TOLL-LIKE
RECEPTOR-3; MAGNESIUM-SULFATE; IMMUNE-SYSTEM; OBSTETRIC COMPLICATIONS;
INTRAUTERINE GROWTH; CEREBRAL-PALSY; PREGNANCY DISORDERS; PRENATAL
INFLUENCES
AB A variety prenatal insults are associated with the incidence of neurodevelopmental disorders such as schizophrenia, autism and cerebral palsy. While the precise mechanisms underlying how transient gestational challenges can lead to later life dysfunctions are largely unknown, the placenta is likely to play a key role. The literal interface between maternal and fetal cells resides in the placenta, and disruptions to the maternal or intrauterine environment are necessarily conveyed to the developing embryo via the placenta. Placental cells bear the responsibility of promoting maternal tolerance of the semiallogeneic fetus and regulating selective permeability of nutrients, gases, and antibodies, while still providing physiological protection of the embryo from adversity. The placenta's critical role in modulating immune protection and the availability of nutrients and endocrine factors to the offspring implicates its involvement in autoimmunity, growth restriction and hypoxia, all factors associated with the development of neurological complications. In this review, we summarize primary maternal-fetal interactions that occur in the placenta and describe pathways by which maternal insults can impair these processes and disrupt fetal brain development. We also review emerging evidence for placental dysfunction in the prenatal programming of neurodevelopmental disorders. (c) 2012 Wiley Periodicals, Inc. Develop Neurobiol, 2012
C1 [Hsiao, Elaine Y.; Patterson, Paul H.] CALTECH, Div Biol, Pasadena, CA 91125 USA.
RP Hsiao, EY (reprint author), CALTECH, Div Biol, Pasadena, CA 91125 USA.
EM ehsiao@caltech.edu
CR Abrahams VM, 2005, J IMMUNOL, V175, P8096
Aluvihare VR, 2004, NAT IMMUNOL, V5, P266, DOI 10.1038/ni1037
Alvir JMJ, 1999, PSYCHOL MED, V29, P621, DOI 10.1017/S0033291799008363
Anderson GM, 2007, BIOL PSYCHIAT, V61, P487, DOI 10.1016/j.biopsych.2006.03.068
Atladottir HO, 2010, J AUTISM DEV DISORD, V40, P1423, DOI 10.1007/s10803-010-1006-y
Bale TL, 2010, BIOL PSYCHIAT, V68, P314, DOI 10.1016/j.biopsych.2010.05.028
BARKER DJP, 1990, BRIT MED J, V301, P259
Bassan H, 2010, J MATERN-FETAL NEO M, V23, P595, DOI [10.1080/14767050903197068, 10.3109/14767050903197068]
Bonnin A, 2011, NATURE, V472, P347, DOI 10.1038/nature09972
Braunschweig D, 2008, NEUROTOXICOLOGY, V29, P226, DOI 10.1016/j.neuro.2007.10.010
Brown AS, 2011, SCHIZOPHRENIA BULL, V37, P284, DOI 10.1093/schbul/sbq146
Brown AS, 2008, SCHIZOPHRENIA BULL, V34, P1054, DOI 10.1093/schbul/sbn096
Bulmer JN, 2010, INT J DEV BIOL, V54, P281, DOI 10.1387/ijdb.082763jb
Carpentier PA, 2011, AM J PATHOL, V178, P2802, DOI 10.1016/j.ajpath.2011.02.042
Cartwright JE, 2010, REPRODUCTION, V140, P803, DOI 10.1530/REP-10-0294
Cartwright JE, 2007, ADV EXP MED BIOL, V618, P113
Clarke MC, 2011, AM J PSYCHIAT, V168, P1295, DOI 10.1176/appi.ajp.2011.11010011
Coe CL, 2000, ANN NY ACAD SCI, V917, P468
Collins KL, 1999, IMMUNOL REV, V168, P65, DOI 10.1111/j.1600-065X.1999.tb01283.x
Cudihy D, 2009, J OBSTET GYNAECOL, V29, P576, DOI 10.1080/01443610903061751
Dahlgren J, 2006, PEDIATR RES, V60, P147, DOI 10.1203/01.pdr.0000230026.74139.18
Dantzer R, 2008, NAT REV NEUROSCI, V9, P46, DOI 10.1038/nrn2297
Dedovic K, 2009, NEUROIMAGE, V47, P864, DOI 10.1016/j.neuroimage.2009.05.074
Dowling O, 2012, PLACENTA, V33, P392, DOI 10.1016/j.placenta.2012.01.013
Doyle LW, 2012, CURR OPIN PEDIATR, V24, P154, DOI 10.1097/MOP.0b013e3283504da1
Fatemi SH, 2011, NEUROPHARMACOLOGY, V62, P1290
Fernandez-Twinn DS, 2010, ANN NY ACAD SCI, V1212, P78, DOI 10.1111/j.1749-6632.2010.05798.x
Fowden AL, 2008, J NEUROENDOCRINOL, V20, P439, DOI 10.1111/j.1365-2826.2008.01663.x
Fruh K, 1999, IMMUNOL REV, V168, P157, DOI 10.1111/j.1600-065X.1999.tb01290.x
Gardener H, 2009, BRIT J PSYCHIAT, V195, P7, DOI 10.1192/bjp.bp.108.051672
Gekas C, 2005, DEV CELL, V8, P365, DOI 10.1016/j.devcel.2004.12.016
Girard S, 2010, J IMMUNOL, V184, P3997, DOI 10.4049/jimmunol.0903349
Hazan AD, 2010, AM J PATHOL, V177, P1017, DOI 10.2353/ajpath.2010.091105
Hirst JJ, 2009, DEV NEUROSCI-BASEL, V31, P363, DOI 10.1159/000232555
Holcberg G, 2004, AM J REPROD IMMUNOL, V51, P192, DOI 10.1111/j.1600-0897.2004.00115.x
Hsiao EY, 2011, BRAIN BEHAV IMMUN, V25, P604, DOI 10.1016/j.bbi.2010.12.017
Hsiao EY, 2011, CELL S AUT SPECTR DI
Hutton LC, 2007, DEV NEUROSCI-BASEL, V29, P341, DOI 10.1159/000105475
Hutton LC, 2008, AM J OBSTET GYNECOL, V198, P117
Ilievski V, 2007, REPROD SCI, V14, P315, DOI 10.1177/1933719107302959
Jansson T, 2007, CLIN SCI, V113, P1, DOI 10.1042/CS20060339
Jarvis S, 2006, CLIN PERINATOL, V33, P285, DOI 10.1016/j.clp.2006.03.009
Kadyrov M, 1998, LANCET, V352, P1747
Koga K, 2010, AM J REPROD IMMUNOL, V63, P587, DOI 10.1111/j.1600-0897.2010.00848.x
Kovac CM, 2003, AM J OBSTET GYNECOL, V189, P839, DOI 10.1067/S0002-9378(03)00851-2
Krechowec SO, 2006, J ENDOCRINOL, V189, P355, DOI 10.1677/joe.1.06679
Limperopoulos C, 2008, PEDIATRICS, V121, P758, DOI 10.1542/peds.2007-2158
Malkova NV, 2012, BRAIN BEHAV IMMUN, V26, P607, DOI 10.1016/j.bbi.2012.01.011
MEDAWAR PB, 1953, SYM SOC EXP BIOL, V7, P320
Moffett A, 2006, NAT REV IMMUNOL, V6, P584, DOI 10.1038/nri1897
O'Callaghan ME, 2011, OBSTET GYNECOL, V118, P576, DOI 10.1097/AOG.0b013e31822ad2dc
Okada Y, 2007, NAT BIOTECHNOL, V25, P233, DOI 10.1038/nbt1280
Onore C., 2011, BRAIN BEHAV IMMUN, V26, P383
Patterson PH, 2011, TRENDS MOL MED, V17, P389, DOI 10.1016/j.molmed.2011.03.001
Patterson PH, 2009, BEHAV BRAIN RES, V204, P313, DOI 10.1016/j.bbr.2008.12.016
Patterson PH, 2007, SCIENCE, V318, P576, DOI 10.1126/science.1150196
Petraglia F, 2010, ENDOCR REV, V31, P783, DOI 10.1210/er.2009-0019
Preti A, 2000, PSYCHIAT RES, V96, P127, DOI 10.1016/S0165-1781(00)00185-2
Redline RW, 2006, CLIN PERINATOL, V33, P503, DOI 10.1016/j.clp.2006.03.007
Redmer DA, 2004, DOMEST ANIM ENDOCRIN, V27, P199, DOI 10.1016/j.domaniend.2004.06.006
Renaud SJ, 2008, IMMUNOL INVEST, V37, P535, DOI 10.1080/08820130802191375
Rhodes KE, 2008, CELL STEM CELL, V2, P252, DOI 10.1016/j.stem.2008.01.001
Roberts CT, 2001, PLACENTA, V22, P177, DOI 10.1053/plac.2000.0602
Sacco R, 2010, AUTISM RES, V3, P237, DOI 10.1002/aur.151
Scaife P, 2003, J SOC GYNECOL INVEST, V10, p360A
Segerstrom SC, 2004, PSYCHOL BULL, V130, P601, DOI 10.1037/0033-2909.130.4.601
Sibley CP, 2005, PEDIATR RES, V58, P827, DOI 10.1203/01.PDR.0000181381.82856.23
Smith SEP, 2007, J NEUROSCI, V27, P10695, DOI 10.1523/JNEUROSCI.2178-07.2007
Sobrian SK, 1997, ENVIRON RES, V73, P227, DOI 10.1006/enrs.1997.3734
TAFURI A, 1995, SCIENCE, V270, P630, DOI 10.1126/science.270.5236.630
Tincani A, 2008, SEMIN THROMB HEMOST, V34, P267, DOI 10.1055/s-0028-1082270
Trowsdale J, 2006, NAT IMMUNOL, V7, P241, DOI 10.1038/ni1317
Warning JC, 2011, REPRODUCTION, V141, P715, DOI 10.1530/REP-10-0360
Wolfberg AJ, 2004, OBSTET GYNECOL, V103, P1190, DOI 10.1097/01.AOG.0000126279.87151.e1
Zhang JH, 2007, INT IMMUNOPHARMACOL, V7, P588, DOI 10.1016/j.intimp.2006.12.014
NR 75
TC 21
Z9 21
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1932-8451
J9 DEV NEUROBIOL
JI Dev. Neurobiol.
PD OCT
PY 2012
VL 72
IS 10
SI SI
BP 1317
EP 1326
DI 10.1002/dneu.22045
PG 10
WC Developmental Biology; Neurosciences
SC Developmental Biology; Neurosciences & Neurology
GA 001NN
UT WOS:000308467500006
PM 22753006
ER
PT J
AU Fox, E
Amaral, D
Van de Water, J
AF Fox, Elizabeth
Amaral, David
Van de Water, Judy
TI Maternal and fetal antibrain antibodies in development and disease
SO DEVELOPMENTAL NEUROBIOLOGY
LA English
DT Review
DE neuronal development; autism spectrum disorders; anti-brain antibodies;
maternal antibodies
ID IMMUNOGLOBULIN-G; BRAIN PROTEINS; AUTISM; AUTOANTIBODIES; CHILDREN;
PREGNANCY; MOTHERS
AB Recent evidence has emerged indicating that the maternal immune response can have a substantial deleterious impact on prenatal development (Croen et al., [2008]: Biol Psychiatry 64:583-588). The maternal immune response is largely sequestered from the fetus. Maternal antibodies, specifically immunoglobulin G (IgG), are passed to the fetus to provide passive immunity throughout much of pregnancy. However, both protective and pathogenic autoantibodies have equal access to the fetus (Goines and Van de Water [2010]: Curr Opin Neurol 23:111-117). If the mother has an underlying autoimmune disease or has reactivity to fetal antigens, autoantibodies produced before or during pregnancy can target tissues in the developing fetus. One such tissue is the fetal brain. The blood brainbarrier (BBB) is developing during the fetal period allowing maternal antibodies to have direct access to the brain during gestation (Diamond et al. [2009]: Nat Rev Immunol; Braunschweig et al. [2011]; Neurotoxicology 29:226-231). It has been proposed that brain injury by circulating brainspecific maternal autoantibodies might underlie multiple congenital, developmental disorders (Lee et al. [2009]: Nat Med 15:91-96). In this review, we will discuss the current state of research in the area of maternal autoantibodies and the development of autism. (c) 2012 Wiley Periodicals, Inc. Develop Neurobiol, 2012
C1 [Fox, Elizabeth; Van de Water, Judy] Univ Calif Davis, Dept Internal Med, Davis, CA 95616 USA.
[Fox, Elizabeth; Amaral, David; Van de Water, Judy] Univ Calif Davis, Davis MIND Inst, Davis, CA 95616 USA.
[Amaral, David] Univ Calif Davis, Dept Psychiat, Davis, CA 95616 USA.
RP Van de Water, J (reprint author), Univ Calif Davis, Dept Internal Med, Davis, CA 95616 USA.
EM javandewater@ucdavis.edu
FU National Institute of Mental Health [R01MH80218, NIEHS 1 P01
ES11269-01]; U. S. Environmental Protection Agency (U.S.EPA) through the
Science to Achieve Results (STAR) program [R829388]; California National
Primate Research Center [RR00169]
FX Contract grant sponsor: National Institute of Mental Health; contract
grant numbers: R01MH80218, NIEHS 1 P01 ES11269-01.Contract grant
sponsor: the U. S. Environmental Protection Agency (U.S.EPA) through the
Science to Achieve Results (STAR) program; contract grant number:
R829388.Contract grant sponsor: California National Primate Research
Center; contract grant number: RR00169.
CR Ashwood P, 2011, J NEUROIMMUNOL, V232, P196, DOI 10.1016/j.jneuroim.2010.10.025
Bauman MD, PRENATAL EXPOS UNPUB
Braunschweig D, J NEUROIMMU IN PRESS
Braunschweig D, 2008, NEUROTOXICOLOGY, V29, P226, DOI 10.1016/j.neuro.2007.10.010
Braunschweig D, 2011, J AUTISM DEV DISORD, V42, P1435
Cabrera RM, 2008, J REPROD IMMUNOL, V79, P85, DOI 10.1016/j.jri.2008.08.002
Croen LA, 2008, BIOL PSYCHIAT, V64, P583, DOI 10.1016/j.biopsych.2008.05.006
Dalton P, 2003, ANN NEUROL, V53, P533, DOI 10.1002/ana.10557
Diamond B, 2009, NAT REV IMMUNOL, V9, P445
GARTY BZ, 1994, CLIN DIAGN LAB IMMUN, V1, P667
Goines P, 2011, BRAIN BEHAV IMMUN, V25, P514, DOI 10.1016/j.bbi.2010.11.017
Goines P, 2011, AUTISM SPECTRUM DISO, P1456
Goines P, 2010, CURR OPIN NEUROL, V23, P111, DOI 10.1097/WCO.0b013e3283373514
Guiseppe M, 2009, J AFFECT DISORDERS, V116, P192
Heuer L, 2011, TRANSL PSYCHIAT, V1, DOI 10.1038/tp.2011.48
Kowal C, 2004, IMMUNITY, V21, P179, DOI 10.1016/j.immuni.2004.07.011
Lee JY, 2009, NAT MED, V15, P91, DOI 10.1038/nm.1892
Martin LA, 2008, BRAIN BEHAV IMMUN, V22, P806, DOI 10.1016/j.bbi.2007.12.007
Murphy K, 2011, JANEWAYS IMMUNOBIOLO
Silva SC, 2004, J NEUROIMMUNOL, V152, P176, DOI 10.1016/j.jneuroim.2004.03.015
Simister NE, 2003, VACCINE, V21, P3365, DOI 10.1016/S0264-410X(03)00334-7
Singer HS, 2008, J NEUROIMMUNOL, V194, P165, DOI 10.1016/j.jneuroim.2007.11.004
Singer HS, 2006, J NEUROIMMUNOL, V178, P149, DOI 10.1016/j.jneuroim.2006.05.025
Singer HS, 2009, J NEUROIMMUNOL, V211, P39, DOI 10.1016/j.jneuroim.2009.03.011
VINCENT A, 1995, J PHYSIOL-PARIS, V89, P129, DOI 10.1016/0928-4257(96)80110-0
Vojdani A, 2002, J NEUROIMMUNOL, V129, P168, DOI 10.1016/S0165-5728(02)00180-7
WARREN RP, 1990, J AM ACAD CHILD PSY, V29, P873, DOI 10.1097/00004583-199011000-00005
Wills S, 2009, BRAIN BEHAV IMMUN, V23, P64, DOI 10.1016/j.bbi.2008.07.007
Zimmerman AW, 2007, BRAIN BEHAV IMMUN, V21, P351, DOI 10.1016/j.bbi.2006.08.005
NR 29
TC 10
Z9 10
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1932-8451
J9 DEV NEUROBIOL
JI Dev. Neurobiol.
PD OCT
PY 2012
VL 72
IS 10
SI SI
BP 1327
EP 1334
DI 10.1002/dneu.22052
PG 8
WC Developmental Biology; Neurosciences
SC Developmental Biology; Neurosciences & Neurology
GA 001NN
UT WOS:000308467500007
PM 22911883
ER
PT J
AU Harvey, L
Boksa, P
AF Harvey, Louise
Boksa, Patricia
TI Prenatal and postnatal animal models of immune activation: Relevance to
a range of neurodevelopmental disorders
SO DEVELOPMENTAL NEUROBIOLOGY
LA English
DT Review
DE prenatal; postnatal; infection; immune activation; neurodevelopment;
disease
ID DEVELOPING RAT-BRAIN; AUTISM SPECTRUM DISORDERS; DOPAMINE NEURON LOSS;
WHITE-MATTER INJURY; BACTERIAL-ENDOTOXIN EXPOSURE; DISRUPTED LATENT
INHIBITION; NONHUMAN PRIMATE MODELS; INDUCED PRETERM BIRTH; MATERNAL
INFECTION; CEREBRAL-PALSY
AB Epidemiological evidence has established links between immune activation during the prenatal or early postnatal period and increased risk of developing a range of neurodevelopment disorders in later life. Animal models have been used to great effect to explore the ramifications of immune activation during gestation and neonatal life. A range of behavioral, neurochemical, molecular, and structural outcome measures associated with schizophrenia, autism, cerebral palsy, and epilepsy have been assessed in models of prenatal and postnatal immune activation. However, the epidemiology-driven disease-first approach taken by some studies can be limiting and, despite the wealth of data, there is a lack of consensus in the literature as to the specific dose, timing, and nature of the immunogen that results in replicable and reproducible changes related to a single disease phenotype. In this review, we highlight a number of similarities and differences in models of prenatal and postnatal immune activation currently being used to investigate the origins of schizophrenia, autism, cerebral palsy, epilepsy, and Parkinson's disease. However, we describe a lack of synthesis not only between but also within disease-specific models. Our inability to compare the equivalency dose of immunogen used is identified as a significant yet easily remedied problem. We ask whether early life exposure to infection should be described as a disease-specific or general vulnerability factor for neurodevelopmental disorders and discuss the implications that either classification has on the design, strengths and limitations offuture experiments. (c) 2012 Wiley Periodicals, Inc. Develop Neurobiol, 2012
C1 [Harvey, Louise; Boksa, Patricia] McGill Univ, Dept Psychiat, Douglas Mental Hlth Univ Inst, Verdun, PQ H4H 1R3, Canada.
RP Boksa, P (reprint author), McGill Univ, Dept Psychiat, Douglas Mental Hlth Univ Inst, Verdun, PQ H4H 1R3, Canada.
EM patricia.boksa@mcgill.ca
CR Abdallah MW, WORLD J BIO IN PRESS
Abdallah MW, 2012, BRAIN BEHAV IMMUN, V26, P170, DOI 10.1016/j.bbi.2011.09.003
Aguilar-Valles A, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0010967
Aguilar-Valles A, 2011, PSYCHONEUROENDOCRINO, V36, P634, DOI 10.1016/j.psyneuen.2010.09.006
Akarsu ES, 2007, AM J PHYSIOL-REG I, V292, pR1846, DOI 10.1152/ajpregu.00786.2006
Amaral DG, 2008, TRENDS NEUROSCI, V31, P137, DOI 10.1016/j.tins.2007.12.005
Ashdown H, 2006, MOL PSYCHIATR, V11, P47, DOI 10.1038/sj.mp.4001748
Ashwood Paul, 2004, Clin Dev Immunol, V11, P165, DOI 10.1080/10446670410001722096
Atladottir HO, 2010, J AUTISM DEV DISORD, V40, P1423, DOI 10.1007/s10803-010-1006-y
Auvin S, 2010, EPILEPSIA, V51, P34, DOI 10.1111/j.1528-1167.2010.02606.x
Auvin S, 2009, EPILEPSY RES, V86, P124, DOI 10.1016/j.eplepsyres.2009.05.010
Auvin S, 2007, EPILEPSIA, V48, P27, DOI 10.1111/j.1528-1167.2007.01286.x
Auvin S, 2010, NEUROBIOL DIS, V40, P303, DOI 10.1016/j.nbd.2010.06.004
Bakos J, 2004, ANN NY ACAD SCI, V1018, P281, DOI 10.1196/annals.1293.033
Bale TL, 2010, BIOL PSYCHIAT, V68, P314, DOI 10.1016/j.biopsych.2010.05.028
BARKER D J P, 1992, Journal of Epidemiology and Community Health, V46, P8, DOI 10.1136/jech.46.1.8
Barker DJ, 2004, J AM COLL NUTR, V23, p588S
Barry PA, 2006, ILAR J, V47, P49
Bauman ML, 2005, INT J DEV NEUROSCI, V23, P183, DOI 10.1016/j.ijdevneu.2004.09.006
Bell MJ, 2002, J NEUROSCI RES, V70, P570, DOI 10.1002/jnr.10423
Beloosesky R, 2010, AM J OBSTET GYNECOL, V203, p[185, e181]
Bilbo SD, 2005, J NEUROSCI, V25, P8000, DOI 10.1523/JNEUROSCI.1748-05.2005
Bitanihirwe BKY, 2010, INT J NEUROPSYCHOPH, V13, P981, DOI 10.1017/S1461145710000192
Boksa P, 2010, BRAIN BEHAV IMMUN, V24, P881, DOI 10.1016/j.bbi.2010.03.005
Bonthius DJ, 2007, PLOS PATHOG, V3, P1541, DOI 10.1371/journal.ppat.0030149
BRIDGES RS, 1984, ENDOCRINOLOGY, V114, P930
Brown AS, 2010, AM J PSYCHIAT, V167, P261, DOI 10.1176/appi.ajp.2009.09030361
Bsibsi M, 2006, GLIA, V53, P688, DOI 10.1002/glia.20328
Burd I, 2010, J NEUROSCI RES, V88, P1872, DOI 10.1002/jnr.22368
Cai ZW, 2000, PEDIATR RES, V47, P64, DOI 10.1203/00006450-200001000-00013
Cambonie G, 2004, J NEUROSCI RES, V75, P125, DOI 10.1002/jnr.10823
Carvey PM, 2003, FRONT BIOSCI-LANDMRK, V8, pS826, DOI 10.2741/1158
Coyle JT, 2004, INT REV NEUROBIOL, V59, P491
Coyle P, 2009, BEHAV BRAIN RES, V197, P210, DOI 10.1016/j.bbr.2008.08.022
Meyer U, 2011, PEDIATR RES, V69, p26R, DOI 10.1203/PDR.0b013e318212c196
de Magistris L, 2010, J PEDIATR GASTR NUTR, V51, P418, DOI 10.1097/MPG.0b013e3181dcc4a5
Duncan JR, 2002, PEDIATR RES, V52, P941, DOI 10.1203/01.PDR.0000034224.13885.BE
Edwards AD, 2006, CURR OPIN PEDIATR, V18, P119, DOI 10.1097/01.mop.0000193290.02270.30
Ehninger D, 2012, MOL PSYCHIATR, V17, P62, DOI 10.1038/mp.2010.115
EKBOM A, 1994, LANCET, V344, P508, DOI 10.1016/S0140-6736(94)91898-8
Ekbom A, 1996, LANCET, V348, P515, DOI 10.1016/S0140-6736(96)04429-7
Eklind S, 2005, PEDIATR RES, V58, P112, DOI 10.1203/01.PDR.0000163513.03619.8D
Elovitz MA, 2011, INT J DEV NEUROSCI, V29, P663, DOI 10.1016/j.ijdevneu.2011.02.011
Ernst LM, 2010, PEDIATR DEVEL PATHOL, V13, P273, DOI 10.2350/09-05-0649-OA.1
Fatemi SH, 2008, SCHIZOPHR RES, V99, P56, DOI 10.1016/j.schres.2007.11.018
Fatemi SH, 2009, SCHIZOPHR RES, V112, P46, DOI 10.1016/j.schres.2009.04.014
Fatemi SH, 1999, MOL PSYCHIATR, V4, P145, DOI 10.1038/sj.mp.4000520
Fatemi SH, 2002, CELL MOL NEUROBIOL, V22, P25, DOI 10.1023/A:1015337611258
Figueiredo MD, 2009, VET IMMUNOL IMMUNOP, V127, P125, DOI 10.1016/j.vetimm.2008.09.028
Folkerth RD, 2005, J CHILD NEUROL, V20, P940, DOI 10.1177/08830738050200120301
Fortier ME, 2004, J PSYCHIAT RES, V38, P335, DOI 10.1016/j.jpsychires.2003.10.001
Fortier ME, 2007, BEHAV BRAIN RES, V181, P270, DOI 10.1016/j.bbr.2007.04.016
Galic MA, 2008, J NEUROSCI, V28, P6904, DOI 10.1523/JNEUROSCI.1901-08.2008
Galic MA, 2009, NEUROBIOL DIS, V36, P343, DOI 10.1016/j.nbd.2009.07.025
Galic MA, 2009, INTEGR COMP BIOL, V49, P237, DOI 10.1093/icb/icp025
Gayle DA, 2004, AM J PHYSIOL-REG I, V286, pR1024, DOI 10.1152/ajpregu.00664.2003
Goines PE, 2011, MOL AUTISM, V2, DOI 10.1186/2040-2392-2-13
Golan HM, 2005, NEUROPHARMACOLOGY, V48, P903, DOI 10.1016/j.neuropharm.2004.12.023
Granholm AC, 2010, BRAIN PATHOL, V21, P330
Han X, 2011, NEUROPSYCHOBIOLOGY, V64, P9, DOI 10.1159/000322455
Hao LY, 2010, NEUROSCIENCE, V166, P763, DOI 10.1016/j.neuroscience.2010.01.006
Harre EM, 2008, EUR J NEUROSCI, V27, P644, DOI 10.1111/j.1460-9568.2008.06031.x
Harvey L, 2012, NEUROPHARMACOLOGY, V62, P1767, DOI 10.1016/j.neuropharm.2011.11.022
Hodyl NA, 2007, J NEUROIMMUNOL, V190, P61, DOI 10.1016/j.jneuroim.2007.07.021
Hornig M, 2001, MENT RETARD DEV D R, V7, P200, DOI 10.1002/mrdd.1028
Howland JG, 2012, NEUROSCIENCE, V201, P184, DOI 10.1016/j.neuroscience.2011.11.011
Ibi D, 2010, BEHAV BRAIN RES, V206, P32, DOI 10.1016/j.bbr.2009.08.027
Jones LA, 2010, J IMMUNOL, V185, P4525, DOI 10.4049/jimmunol.0901155
Kemp MW, 2010, REPROD SCI, V17, P619, DOI 10.1177/1933719110373148
KIM YS, 1995, J NEUROPATH EXP NEUR, V54, P531
Kinney H C, 1998, Semin Pediatr Neurol, V5, P180, DOI 10.1016/S1071-9091(98)80033-8
Kolarova A, 2003, BMC NEUROSCI, V4, DOI 10.1186/1471-2202-4-21
Lam KSL, 2006, RES DEV DISABIL, V27, P254, DOI 10.1016/j.ridd.2005.03.003
Landrigan PJ, 2010, CURR OPIN PEDIATR, V22, P219, DOI 10.1097/MOP.0b013e328336eb9a
Lante F, 2008, HIPPOCAMPUS, V18, P602, DOI 10.1002/hipo.20421
Levison SW, 2001, DEV NEUROSCI-BASEL, V23, P234, DOI 10.1159/000046149
Levy SE, 2007, BIOL PSYCHIAT, V61, P492, DOI 10.1016/j.biopsych.2006.07.013
Libbey JE, 2011, FUTURE VIROL, V6, P1339, DOI 10.2217/FVL.11.107
Ling ZD, 2006, EXP NEUROL, V199, P499, DOI 10.1016/j.expneurol.2006.01.010
Ling ZD, 2004, NEUROSCIENCE, V124, P619, DOI 10.1016/j.neuroscience.2003.12.017
Ling ZD, 2002, MOVEMENT DISORD, V17, P116, DOI 10.1002/mds.10078
Ling ZD, 2009, EXP NEUROL, V216, P312, DOI 10.1016/j.expneurol.2008.12.004
Ling ZD, 2004, EXP NEUROL, V190, P373, DOI 10.1016/j.expneurol.2004.08.006
Lodygensky GA, 2010, BRAIN BEHAV IMMUN, V24, P759, DOI 10.1016/j.bbi.2009.11.005
Lowe GC, 2008, AM J PHYSIOL-REG I, V295, pR1563, DOI 10.1152/ajpregu.90350.2008
Luheshi GN, 1997, AM J PHYSIOL-REG I, V272, pR862
Magni DV, 2011, EPILEPSY RES, V93, P138, DOI 10.1016/j.eplepsyres.2010.11.007
Makinodan M, 2008, J NEUROSCI RES, V86, P2190, DOI 10.1002/jnr.21673
Malkova NV, 2012, BRAIN BEHAV IMMUN, V26, P607, DOI 10.1016/j.bbi.2012.01.011
Meyer U, 2008, NEUROPSYCHOPHARMACOL, V33, P441, DOI 10.1038/sj.npp.1301413
Meyer U, 2008, BRAIN BEHAV IMMUN, V22, P469, DOI 10.1016/j.bbi.2007.09.012
Meyer U, 2008, NEUROSCIENCE, V154, P701, DOI 10.1016/j.neuroscience.2008.04.031
Meyer U, 2006, BRAIN BEHAV IMMUN, V20, P378, DOI 10.1016/j.bbi.2005.11.003
Meyer U, 2006, J NEUROSCI, V26, P4752, DOI 10.1523/JNEUROSCI.0099-06.2006
Nakazawa K., 2011, NEUROPHARMACOLOGY, V62, P1574
Nelson Karin B., 2000, Current Opinion in Neurology, V13, P133, DOI 10.1097/00019052-200004000-00004
Nelson KB, 2008, CLIN OBSTET GYNECOL, V51, P749, DOI 10.1097/GRF.0b013e318187087c
Neufeld KA, 2009, J PSYCHIATR NEUROSCI, V34, P230
Nielsen LLW, 1998, BRIT MED J, V316, P196
Nouel D, 2012, EUR NEUROPSYCHOPHARM, V22, P300, DOI 10.1016/j.euroneuro.2011.08.001
Ozawa K, 2006, BIOL PSYCHIAT, V59, P546, DOI 10.1016/j.biopsych.2005.07.031
Paintlia MK, 2004, J NEUROSCI RES, V78, P347, DOI 10.1002/jnr.20261
Paintlia MK, 2008, EXP NEUROL, V210, P560, DOI 10.1016/j.expneurol.2007.12.011
Pakula AT, 2009, PHYS MED REHABIL CLI, V20, P427, DOI 10.1016/j.pmr.2009.06.001
Pang Y, 2003, DEV BRAIN RES, V140, P205, DOI 10.1016/S0165-3806(02)00606-5
Pardi DS, 1999, INFLAMM BOWEL DIS, V5, P104
Patterson PH, 2012, BRAIN BEHAV IMMUN, V26, P393, DOI 10.1016/j.bbi.2011.09.008
Perry W, 2007, BIOL PSYCHIAT, V61, P482, DOI 10.1016/j.biopsych.2005.09.025
RAY A, 1991, FEMS MICROBIOL LETT, V79, P211, DOI 10.1111/j.1574-6968.1991.tb04531.x
Reddihough DS, 2003, AUST J PHYSIOTHER, V49, P7
Reimer T, 2008, J LEUKOCYTE BIOL, V83, P1249, DOI 10.1189/jlb.0607412
Romero E, 2010, MOL PSYCHIATR, V15, P372, DOI 10.1038/mp.2008.44
Romero E, 2007, NEUROPSYCHOPHARMACOL, V32, P1791, DOI 10.1038/sj.npp.1301292
Romero R, 2007, NUTR REV, V65, pS194, DOI 10.1301/nr.2007.dec.S194-S202
Roth J, 2009, IMMUNOL ALLERGY CLIN, V29, P229, DOI 10.1016/j.iac.2009.02.005
Roumier A, 2008, PLOS ONE, V3, DOI 10.1371/journal.pone.0002595
Samuelsson AM, 2006, AM J PHYSIOL-REG I, V290, pR1345, DOI 10.1152/ajpregu.00268.2005
Schlotz W, 2009, BRAIN BEHAV IMMUN, V23, P905, DOI 10.1016/j.bbi.2009.02.001
Shi LM, 2009, BRAIN BEHAV IMMUN, V23, P116, DOI 10.1016/j.bbi.2008.07.012
Shi LM, 2003, J NEUROSCI, V23, P297
Sinclair KD, 2007, THERIOGENOLOGY, V67, P43, DOI 10.1016/j.theriogenology.2006.09.017
Sinclair K D, 2007, Soc Reprod Fertil Suppl, V64, P425
Smith SEP, 2007, J NEUROSCI, V27, P10695, DOI 10.1523/JNEUROSCI.2178-07.2007
Spencer SJ, 2011, AM J PHYSIOL-ENDOC M, V300, pE11, DOI 10.1152/ajpendo.00516.2010
Spencer SJ, 2007, AM J PHYSIOL-REG I, V292, pR308, DOI 10.1152/ajpregu.00398.2006
Spencer SJ, 2006, J CEREBR BLOOD F MET, V26, P456, DOI 10.1038/sj.jcbfm.9600206
Stewart KAA, 2010, J NEUROPATH EXP NEUR, V69, P1210, DOI 10.1097/NEN.0b013e3181ffc420
Tohmi M, 2004, NEUROSCI RES, V50, P67, DOI 10.1016/j.neures.2004.05.010
Urakubo A, 2001, SCHIZOPHR RES, V47, P27, DOI 10.1016/S0920-9964(00)00032-3
VANDEBOR M, 1989, PEDIATRICS, V84, P407
Vuillermot S, 2012, J NEUROSCI, V32, P436, DOI 10.1523/JNEUROSCI.4831-11.2012
Waldorf KMA, 2011, BJOG-INT J OBSTET GY, V118, P136, DOI 10.1111/j.1471-0528.2010.02728.x
Wang S, 2009, BRAIN RES, V1265, P196, DOI 10.1016/j.brainres.2009.02.022
Wang XY, 2009, J IMMUNOL, V183, P7471, DOI 10.4049/jimmunol.0900762
White JF, 2003, EXP BIOL MED, V228, P639
Wing L, 1997, LANCET, V350, P1761, DOI 10.1016/S0140-6736(97)09218-0
Winter C, 2008, EUR NEUROPSYCHOPHARM, V18, P712, DOI 10.1016/j.euroneuro.2008.06.001
Winter C, 2009, INT J NEUROPSYCHOPH, V12, P513, DOI 10.1017/S1461145708009206
Wolff AR, 2008, BEHAV BRAIN RES, V190, P156, DOI 10.1016/j.bbr.2008.02.021
WUSTEMAN M, 1990, AM J PHYSIOL, V259, pE763
Zhang Y, 2012, NEUROPHARMACOLOGY, V62, P1299, DOI 10.1016/j.neuropharm.2011.02.022
Zuckerman L, 2003, NEUROPSYCHOPHARMACOL, V28, P1778, DOI 10.1038/sj.npp.1300248
Zuckerman L, 2003, PSYCHOPHARMACOLOGY, V169, P308, DOI 10.1007/s00213-003-1461-7
Zuckerman L, 2003, PSYCHOPHARMACOLOGY, V169, P298, DOI 10.1007/s00213-003-1460-8
NR 144
TC 23
Z9 23
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1932-8451
J9 DEV NEUROBIOL
JI Dev. Neurobiol.
PD OCT
PY 2012
VL 72
IS 10
SI SI
BP 1335
EP 1348
DI 10.1002/dneu.22043
PG 14
WC Developmental Biology; Neurosciences
SC Developmental Biology; Neurosciences & Neurology
GA 001NN
UT WOS:000308467500008
PM 22730147
ER
PT J
AU O'Reilly, M
Cook, L
Karim, K
AF O'Reilly, Michelle
Cook, Laura
Karim, Khalid
TI Complementary or controversial care? The opinions of professionals on
complementary and alternative interventions for Autistic Spectrum
Disorder
SO CLINICAL CHILD PSYCHOLOGY AND PSYCHIATRY
LA English
DT Article
DE Autism; complementary therapies; perceptions; professionals; qualitative
AB The use of complementary and alternative interventions is growing and gaining popularity, both in the UK and internationally, with significant financial and emotional implications. Complementary and alternative interventions are often utilised by parents of children with Autistic Spectrum Disorders and research has investigated parental beliefs. There is, however, limited understanding regarding what professionals believe about the use of alternative treatments. In this paper we explore the opinions of a range of different professionals about alternative treatments and found that while some have an open-minded opinion, there was a tendency to hold beliefs that these treatments are ineffective, that they give false hope and have potential to harm the child. We discuss the implications for this in terms of the importance of an open dialogue between professionals and families and consider the importance of this in relation to the popularity of these interventions.
C1 [O'Reilly, Michelle; Karim, Khalid] Univ Leicester, Div Psychiat, Leicester LE3 0QU, Leics, England.
[Cook, Laura] Univ Leicester, Leicester LE3 0QU, Leics, England.
RP O'Reilly, M (reprint author), Univ Leicester, Greenwood Inst, Dept Psychol, Westcotes Dr, Leicester LE3 0QU, Leics, England.
EM Mjo14@le.ac.uk
CR Barrett B, 2004, ANN FAM MED, V2, P253, DOI 10.1370/afm.81
Boyatzis RE, 1998, TRANSFORMING QUALITA
Braun V., 2006, QUALITATIVE RES PSYC, V3, P77, DOI DOI 10.1191/1478088706QP063OA
Bromley J, 2004, AUTISM, V8, P409, DOI 10.1177/1362361304047224
Bryman A., 2008, SOCIAL RES METHODS, V3rd
Cartwright T, 2005, J HEALTH PSYCHOL, V10, P559, DOI 10.1177/1359105305053425
Chan E, 2002, J DEV BEHAV PEDIATR, V23, pS37
Dawkins Richard, 2003, DEVILS CHAPLAIN REFL
Department of Health, 1999, RES WHAT IT CONS REP
Gaskell G., 2000, QUALITATIVE RES TEXT, P38
Goin-Kochel RP, 2007, RES AUTISM SPECT DIS, V1, P195, DOI 10.1016/j.rasd.2006.08.006
Golnik AE, 2009, J AUTISM DEV DISORD, V39, P996, DOI 10.1007/s10803-009-0714-7
Hanson E, 2007, J AUTISM DEV DISORD, V37, P628, DOI 10.1007/s10803-006-0192-0
Happe F, 2006, NAT NEUROSCI, V9, P1218, DOI 10.1038/nn1770
Harrington JW, 2006, AUTISM, V10, P452, DOI 10.1177/1362361306066609
Smith T, 2005, CONTROVERSIAL THERAPIES FOR DEVELOPMENTAL DISABILITES: FAD, FASHION, AND SCIENCE IN PROFESSIONAL PRACTICE, P45
Kelly KM, 2004, EUR J CANCER, V40, P2041, DOI 10.1016/j.ejca.2004.05.012
Kemper KJ, 2001, ARCH DIS CHILD, V84, P6, DOI 10.1136/adc.84.1.6
Knapp M., 2007, EC CONSEQUENCES AUTI
Kronenberg F, 2006, AM J PUBLIC HEALTH, V96, P1236, DOI 10.2105/AJPH.2004.047688
Kurtz L., 2008, UNDERSTANDING CONTRO
Kvale S., 1996, INTERVIEWS INTRO QUA
Levy SE, 2005, MENT RETARD DEV D R, V11, P131, DOI 10.1002/mrdd.20062
Levy SE, 2003, J DEV BEHAV PEDIATR, V24, P418, DOI 10.1097/00004703-200312000-00003
Mackenzie ER, 2003, ALTERN THER HEALTH M, V9, P50
Maha Nita, 2007, BMC Complement Altern Med, V7, P17, DOI 10.1186/1472-6882-7-17
Matson JL, 2007, RES DEV DISABIL, V28, P207, DOI 10.1016/j.ridd.2005.07.006
Milden SP, 2004, BEHAV MED, V30, P73, DOI 10.3200/BMED.30.2.73-84
Myers SM, 2007, PEDIATRICS, V120, P1162, DOI 10.1542/peds.2007-2362
O'Reilly M., QUALITATIVE IN PRESS
O'Callaghan FV, 2003, COMPLEMENT THER MED, V11, P28, DOI 10.1016/S0965-2299(02)00109-7
Schmidt K, 2004, ANN ONCOL, V15, P733, DOI 10.1093/annonc/mdh174
SHARPE D. L., 2007, J FAMILY EC ISSUES, V28, P247, DOI 10.1007/s10834-007-9059-6
Sikand A, 1998, ARCH PEDIAT ADOL MED, V152, P1059
Sonitu E., 2006, SOCIOLOGY HLTH ILLNE, V28, P330
Spencer L., 2003, QUALITY QUALITATIVE
Tuson J., 2005, CTR STUDY COMPLEMENT
Winnick TA, 2005, SOC PROBL, V52, P38, DOI 10.1525/sp.2005.52.1.38
Wong HHL, 2006, J AUTISM DEV DISORD, V36, P901, DOI 10.1007/s10803-006-0131-0
Wong VCN, 2009, J AUTISM DEV DISORD, V39, P454, DOI 10.1007/s10803-008-0644-9
Wood JJ, 2009, J CHILD PSYCHOL PSYC, V50, P224, DOI 10.1111/j.1469-7610.2008.01948.x
Zollman C, 1999, BRIT MED J, V319, P693
Zuess J., 2003, COMPLEMENTARY HLTH P, V8, P193, DOI 10.1177/1076167503253855
NR 43
TC 0
Z9 0
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1359-1045
EI 1461-7021
J9 CLIN CHILD PSYCHOL P
JI Clin. Child Psychol. Psychiatry
PD OCT
PY 2012
VL 17
IS 4
BP 602
EP 615
DI 10.1177/1359104511435340
PG 14
WC Psychology, Clinical; Psychology, Developmental; Psychiatry; Psychology
SC Psychology; Psychiatry
GA V32IV
UT WOS:000208945800010
PM 22371629
ER
PT J
AU Goldman, GS
Miller, NZ
AF Goldman, G. S.
Miller, N. Z.
TI Relative trends in hospitalizations and mortality among infants by the
number of vaccine doses and age, based on the Vaccine Adverse Event
Reporting System (VAERS), 1990-2010
SO HUMAN & EXPERIMENTAL TOXICOLOGY
LA English
DT Article
DE VAERS; vaccine; childhood vaccines; immunization; epidemiology; infant
mortality; SIDS; drug toxicology; human toxicology
ID HEPATITIS-B VACCINATION; MULTIPLE-SCLEROSIS; HEXAVALENT VACCINATION;
DEATH-SYNDROME; CHILDHOOD; AUTISM; RISK
AB In this study, the Vaccine Adverse Event Reporting System (VAERS) database, 1990-2010, was investigated; cases that specified either hospitalization or death were identified among 38,801 reports of infants. Based on the types of vaccines reported, the actual number of vaccine doses administered, from 1 to 8, was summed for each case. Linear regression analysis of hospitalization rates as a function of (a) the number of reported vaccine doses and (b) patient age yielded a linear relationship with r(2) = 0.91 and r(2) = 0.95, respectively. The hospitalization rate increased linearly from 11.0% (107 of 969) for 2 doses to 23.5% (661 of 2817) for 8 doses and decreased linearly from 20.1% (154 of 765) for children aged < 0.1 year to 10.7% (86 of 801) for children aged 0.9 year. The rate ratio (RR) of the mortality rate for 5-8 vaccine doses to 1-4 vaccine doses is 1.5 (95% confidence interval (CI), 1.4-1.7), indicating a statistically significant increase from 3.6% (95% CI, 3.2-3.9%) deaths associated with 1-4 vaccine doses to 5.5% (95% CI, 5.2-5.7%) associated with 5-8 vaccine doses. The male-to-female mortality RR was 1.4 (95% CI, 1.3-1.5). Our findings show a positive correlation between the number of vaccine doses administered and the percentage of hospitalizations and deaths. Since vaccines are given to millions of infants annually, it is imperative that health authorities have scientific data from synergistic toxicity studies on all combinations of vaccines that infants might receive. Finding ways to increase vaccine safety should be the highest priority.
C1 [Miller, N. Z.] Thinktwice Vaccine Inst, Santa Fe, NM USA.
RP Goldman, GS (reprint author), POB 847, Pearblossom, CA 93553 USA.
EM gsgoldman@roadrunner.com
FU National Vaccine Information Center (NVIC)
FX This work is funded by the National Vaccine Information Center (NVIC)
who donated $2,500 towards the SAGE Choice Open Access fee for this
article.
CR Braun M., 2006, VACCINE ADVERSE EVEN
Castranova V, 2005, MIXED EXPOSURES RES, P106
DeLong G, 2011, J TOXICOL ENV HEAL A, V74, P903, DOI 10.1080/15287394.2011.573736
Dettman G, 1993, VITAMIN C NATURES MI, P1
Geier DA, 2004, EXPERT OPIN PHARMACO, V5, P691, DOI 10.1517/eoph.5.3.691.27375
Gran B, 2000, NEUROLOGY, V54, pA164
Guess HA, 1999, EPIDEMIOL REV, V21, P93
Hernan MA, 2004, NEUROLOGY, V63, P838
Institute of Medicine, 1992, VACC SAF COMM P, P40
KESSLER DA, 1993, JAMA-J AM MED ASSOC, V269, P2765, DOI 10.1001/jama.269.21.2765
Konstantinou D, 2001, CLIN INFECT DIS, V33, P1772, DOI 10.1086/322617
Kuhnert R, 2011, STAT MED, V30, P666, DOI 10.1002/sim.4120
Mage DT, 2004, ACTA PAEDIATR, V93, P1210, DOI 10.1080/08035250410031305
Mikaeloff Y, 2009, NEUROLOGY, V72, P873, DOI 10.1212/01.wnl.0000335762.42177.07
Miller NZ, 2011, HUM EXP TOXICOL, V30, P1420, DOI 10.1177/0960327111407644
Moon RY, 2007, PEDIATR REV, V28, P209, DOI 10.1542/pir.28-6-209
Ness JM, 2009, NEUROLOGY, V72, P870, DOI 10.1212/01.wnl.0000339450.71918.54
Oestergaard MZ, 2011, PLOS MED, V8, DOI 10.1371/journal.pmed.1001080
Ottaviani G, 2006, VIRCHOWS ARCH, V448, P100, DOI 10.1007/s00428-005-0072-6
Poling JS, 2006, J CHILD NEUROL, V21, P170, DOI 10.2310/7010.2006.00032
Prandota Joseph, 2004, Am J Ther, V11, P517, DOI 10.1097/01.mjt.0000140648.30948.bd
Rosenthal S, 1995, AM J PUBLIC HEALTH, V85, P1706, DOI 10.2105/AJPH.85.12.1706
Sinsawaiwong Suwanna, 2000, Journal of the Medical Association of Thailand, V83, P1124
Terney D, 2006, CHINESE MED J-PEKING, V119, P77
Varricchio F, 2004, PEDIATR INFECT DIS J, V23, P287, DOI 10.1097/00006454-200404000-00002
Zhou Weigong, 2003, MMWR Surveill Summ, V52, P1
Zinka B, 2006, VACCINE, V24, P5779, DOI 10.1016/j.vaccine.2005.03.047
NR 27
TC 5
Z9 7
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0960-3271
EI 1477-0903
J9 HUM EXP TOXICOL
JI Hum. Exp. Toxicol.
PD OCT
PY 2012
VL 31
IS 10
BP 1012
EP 1021
DI 10.1177/0960327112440111
PG 10
WC Toxicology
SC Toxicology
GA 019BW
UT WOS:000309712900004
PM 22531966
ER
PT J
AU Higashida, H
Munesue, T
AF Higashida, H.
Munesue, T.
TI CD38 and autism spectrum disorders
SO JOURNAL OF NEUROCHEMISTRY
LA English
DT Meeting Abstract
C1 [Higashida, H.; Munesue, T.] Kanazawa Univ, Ctr Child Mental Dev, Kanazawa, Ishikawa, Japan.
NR 0
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0022-3042
EI 1471-4159
J9 J NEUROCHEM
JI J. Neurochem.
PD OCT
PY 2012
VL 123
SU 1
SI SI
BP 4
EP 5
DI 10.1111/j.1471-4159.2012.07907.x
PG 2
WC Biochemistry & Molecular Biology; Neurosciences
SC Biochemistry & Molecular Biology; Neurosciences & Neurology
GA V31EE
UT WOS:000208866100006
ER
PT J
AU Kato, N
Kanai, C
Ikeda, A
Yamada, T
Nakamura, M
Hashimoto, R
AF Kato, N.
Kanai, C.
Ikeda, A.
Yamada, T.
Nakamura, M.
Hashimoto, R.
TI Clinical studies of adults with Asperger syndrome - exploring the neural
basis of autism spectrum disorders (ASD)
SO JOURNAL OF NEUROCHEMISTRY
LA English
DT Meeting Abstract
C1 [Kato, N.; Ikeda, A.; Yamada, T.; Nakamura, M.] Showa Univ, Sch Med, Dept Psychiat, Karasuyama Hosp, Tokyo 142, Japan.
[Kato, N.] CREST, JST, Tokyo, Japan.
[Kanai, C.] Sagami Womens Univ, Dept Educ & Child Studies, Sagamihara, Kanagawa, Japan.
[Hashimoto, R.] Tokyo Metropolitan Univ, Dept Language Sci, Tokyo 158, Japan.
NR 0
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0022-3042
EI 1471-4159
J9 J NEUROCHEM
JI J. Neurochem.
PD OCT
PY 2012
VL 123
SU 1
SI SI
BP 4
EP 4
DI 10.1111/j.1471-4159.2012.07904.x
PG 1
WC Biochemistry & Molecular Biology; Neurosciences
SC Biochemistry & Molecular Biology; Neurosciences & Neurology
GA V31EE
UT WOS:000208866100003
ER
PT J
AU Geschwind, D
AF Geschwind, D.
TI Systems biology analyses of autism spectrum disorders (ASD)
SO JOURNAL OF NEUROCHEMISTRY
LA English
DT Meeting Abstract
C1 [Geschwind, D.] Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA 90095 USA.
NR 0
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0022-3042
EI 1471-4159
J9 J NEUROCHEM
JI J. Neurochem.
PD OCT
PY 2012
VL 123
SU 1
SI SI
BP 30
EP 30
PG 1
WC Biochemistry & Molecular Biology; Neurosciences
SC Biochemistry & Molecular Biology; Neurosciences & Neurology
GA V31EE
UT WOS:000208866100065
ER
PT J
AU Kosaka, H
AF Kosaka, H.
TI Neuroimaging and oxytocin effect in youth with autism spectrum disorders
SO JOURNAL OF NEUROCHEMISTRY
LA English
DT Meeting Abstract
C1 [Kosaka, H.] Univ Fukui, Res Ctr Child Mental Dev, Fukui 910, Japan.
[Kosaka, H.] Univ Fukui, Fac Med Sci, Dept Neuropsychiat, Fukui 910, Japan.
NR 0
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0022-3042
EI 1471-4159
J9 J NEUROCHEM
JI J. Neurochem.
PD OCT
PY 2012
VL 123
SU 1
SI SI
BP 30
EP 30
PG 1
WC Biochemistry & Molecular Biology; Neurosciences
SC Biochemistry & Molecular Biology; Neurosciences & Neurology
GA V31EE
UT WOS:000208866100068
ER
PT J
AU Mori, N
AF Mori, N.
TI Positron emission tomography in autism spectrum disorders
SO JOURNAL OF NEUROCHEMISTRY
LA English
DT Meeting Abstract
C1 [Mori, N.] Hamamatsu Univ Sch Med, Dept Psychiat, Hamamatsu, Shizuoka 4313192, Japan.
NR 0
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0022-3042
EI 1471-4159
J9 J NEUROCHEM
JI J. Neurochem.
PD OCT
PY 2012
VL 123
SU 1
SI SI
BP 30
EP 30
PG 1
WC Biochemistry & Molecular Biology; Neurosciences
SC Biochemistry & Molecular Biology; Neurosciences & Neurology
GA V31EE
UT WOS:000208866100067
ER
PT J
AU Tabuchi, K
AF Tabuchi, K.
TI Synapse maturation and autism: The role of neuroligins and neurexins
SO JOURNAL OF NEUROCHEMISTRY
LA English
DT Meeting Abstract
C1 [Tabuchi, K.] Precursory Res Embryon Sci & Technol PRESTO, Tokyo, Japan.
NR 0
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0022-3042
EI 1471-4159
J9 J NEUROCHEM
JI J. Neurochem.
PD OCT
PY 2012
VL 123
SU 1
SI SI
BP 30
EP 30
PG 1
WC Biochemistry & Molecular Biology; Neurosciences
SC Biochemistry & Molecular Biology; Neurosciences & Neurology
GA V31EE
UT WOS:000208866100066
ER
PT J
AU Egawa, J
Watanabe, Y
Nunokawa, A
Endo, T
Kaneko, N
Tamura, R
Sugiyama, T
Someya, T
AF Egawa, J.
Watanabe, Y.
Nunokawa, A.
Endo, T.
Kaneko, N.
Tamura, R.
Sugiyama, T.
Someya, T.
TI Rare missense variations of TPH2 and risk of autism: Exon resequensing
and association analysis
SO JOURNAL OF NEUROCHEMISTRY
LA English
DT Meeting Abstract
C1 [Egawa, J.; Watanabe, Y.; Nunokawa, A.; Endo, T.; Kaneko, N.; Tamura, R.; Someya, T.] Niigata Univ, Grad Sch Med & Dent Sci, Dept Psychiat, Niigata, Japan.
[Egawa, J.] Saigata Natl Hosp, Natl Hosp Org, Dept Psychiat, Niigata, Japan.
[Sugiyama, T.] Hamamatsu Univ, Sch Med, Dept Child & Adolescent Psychiat, Shizuoka, Japan.
[Kaneko, N.] Oojima Hosp, Niigata, Japan.
NR 0
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0022-3042
EI 1471-4159
J9 J NEUROCHEM
JI J. Neurochem.
PD OCT
PY 2012
VL 123
SU 1
SI SI
BP 69
EP 69
PG 1
WC Biochemistry & Molecular Biology; Neurosciences
SC Biochemistry & Molecular Biology; Neurosciences & Neurology
GA V31EE
UT WOS:000208866100183
ER
PT J
AU Jaiswal, P
Guhathakurta, S
Sinha, S
Mohanakumar, K
Rajamma, U
AF Jaiswal, P.
Guhathakurta, S.
Sinha, S.
Mohanakumar, K.
Rajamma, U.
TI Genetic analysis of STin2 VNTR marker of serotonin transporter gene
(SLC6A4) and its allele specific modulation of platelet serotonin level
in autism spectrum disorder
SO JOURNAL OF NEUROCHEMISTRY
LA English
DT Meeting Abstract
C1 [Jaiswal, P.; Guhathakurta, S.; Sinha, S.; Rajamma, U.] Manovikas Kendra Rehabil & Res Inst Handicapped, Manovikas Biomed Res & Diagnost Ctr, Kolkata, India.
[Mohanakumar, K.] Indian Inst Chem Biol, Cell Biol & Physiol Div, Kolkata, India.
NR 0
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0022-3042
EI 1471-4159
J9 J NEUROCHEM
JI J. Neurochem.
PD OCT
PY 2012
VL 123
SU 1
SI SI
BP 70
EP 70
PG 1
WC Biochemistry & Molecular Biology; Neurosciences
SC Biochemistry & Molecular Biology; Neurosciences & Neurology
GA V31EE
UT WOS:000208866100187
ER
PT J
AU Mouri, M
Negishi, T
Tashiro, T
AF Mouri, M.
Negishi, T.
Tashiro, T.
TI Alterations in neuronal maturation in a rat model of autism induced by
fetal thalidomide exposure
SO JOURNAL OF NEUROCHEMISTRY
LA English
DT Meeting Abstract
C1 [Mouri, M.; Negishi, T.; Tashiro, T.] Aoyama Gakuin Univ, Sch Sci & Engn, Dept Chem & Biol Sci, Tokyo 150, Japan.
NR 0
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0022-3042
EI 1471-4159
J9 J NEUROCHEM
JI J. Neurochem.
PD OCT
PY 2012
VL 123
SU 1
SI SI
BP 70
EP 70
PG 1
WC Biochemistry & Molecular Biology; Neurosciences
SC Biochemistry & Molecular Biology; Neurosciences & Neurology
GA V31EE
UT WOS:000208866100186
ER
PT J
AU Xu, M
Iwasaki, T
Sajdel-Sulkowska, EM
Shimokawa, N
Koibuchi, N
AF Xu, M.
Iwasaki, T.
Sajdel-Sulkowska, E. M.
Shimokawa, N.
Koibuchi, N.
TI Abnormal cerebellar neurotrophin expression in autism patients and
LPS-exposure rat model
SO JOURNAL OF NEUROCHEMISTRY
LA English
DT Meeting Abstract
C1 [Xu, M.] Keio Univ, Sch Med, Dept Neuropsychiat, Tokyo 108, Japan.
[Iwasaki, T.; Shimokawa, N.; Koibuchi, N.] Gunma Univ, Dept Integrat Physiol, Gunma, Japan.
[Sajdel-Sulkowska, E. M.] Brigham & Womens Hosp, Dept Psychiat, Boston, MA 02115 USA.
NR 0
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0022-3042
EI 1471-4159
J9 J NEUROCHEM
JI J. Neurochem.
PD OCT
PY 2012
VL 123
SU 1
SI SI
BP 70
EP 70
PG 1
WC Biochemistry & Molecular Biology; Neurosciences
SC Biochemistry & Molecular Biology; Neurosciences & Neurology
GA V31EE
UT WOS:000208866100188
ER
PT J
AU Iwata, K
Nakabayashi, K
Matsuzaki, H
Nakamura, K
Hata, K
Mori, N
AF Iwata, K.
Nakabayashi, K.
Matsuzaki, H.
Nakamura, K.
Hata, K.
Mori, N.
TI Genome-wide DNA methylation profiles in post-mortem brains from subjects
with autism
SO JOURNAL OF NEUROCHEMISTRY
LA English
DT Meeting Abstract
C1 [Iwata, K.; Matsuzaki, H.] Hamamatsu Univ Sch Med, RCCMD, Hamamatsu, Shizuoka 4313192, Japan.
[Nakabayashi, K.; Hata, K.] NCCHD, Dept Maternal Fetal Biol, Setagaya Ku, Tokyo, Japan.
[Nakamura, K.; Mori, N.] Hamamatsu Univ Sch Med, Dept Psychiat, Hamamatsu, Shizuoka 4313192, Japan.
NR 0
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0022-3042
EI 1471-4159
J9 J NEUROCHEM
JI J. Neurochem.
PD OCT
PY 2012
VL 123
SU 1
SI SI
BP 71
EP 71
PG 1
WC Biochemistry & Molecular Biology; Neurosciences
SC Biochemistry & Molecular Biology; Neurosciences & Neurology
GA V31EE
UT WOS:000208866100190
ER
PT J
AU Payakachat, N
Hoefman, R
Kovacs, E
Van Exel, J
Pyne, JM
Kuhlthau, KA
Tilford, J
Brouwer, W
AF Payakachat, Nalin
Hoefman, Renske
Kovacs, Erica
Van Exel, Job
Pyne, Jeffery M.
Kuhlthau, Karen A.
Tilford, John
Brouwer, Werner
TI Quality of life among parents of children with autism spectrum
disorders: a comparison of generic instruments
SO QUALITY OF LIFE RESEARCH
LA English
DT Meeting Abstract
C1 [Payakachat, Nalin; Tilford, John] Univ Arkansas Med Sci, Little Rock, AR 72205 USA.
[Hoefman, Renske; Van Exel, Job; Brouwer, Werner] Erasmus Univ, Rotterdam, Netherlands.
[Kovacs, Erica] Columbia Univ, Med Ctr, Div Child & Adolescent Psychiat, New York, NY 10027 USA.
[Pyne, Jeffery M.] Univ Arkansas Med Sci, Coll Med, Little Rock, AR 72205 USA.
[Kuhlthau, Karen A.] Ctr Child & Adolescent Hlth Policy, Boston, MA USA.
NR 0
TC 0
Z9 0
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0962-9343
EI 1573-2649
J9 QUAL LIFE RES
JI Qual. Life Res.
PD OCT
PY 2012
VL 21
SU 1
MA 306.2
BP 37
EP 38
PG 2
WC Health Care Sciences & Services; Health Policy & Services; Public,
Environmental & Occupational Health
SC Health Care Sciences & Services; Public, Environmental & Occupational
Health
GA V38QW
UT WOS:000209358900101
ER
PT J
AU Villes, V
Bartolini, AM
Chatel, C
Poinso, F
AF Villes, Virginie
Bartolini, Anne-Marie
Chatel, Clarisse
Poinso, Francois
TI Impairment of quality of life in parents of children with autism
spectrum disorder
SO QUALITY OF LIFE RESEARCH
LA English
DT Meeting Abstract
C1 [Villes, Virginie] Publ Hlth Lab, Marseilles, France.
[Bartolini, Anne-Marie; Chatel, Clarisse; Poinso, Francois] Resource Autism Ctr, Marseilles, France.
NR 0
TC 0
Z9 0
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0962-9343
EI 1573-2649
J9 QUAL LIFE RES
JI Qual. Life Res.
PD OCT
PY 2012
VL 21
SU 1
MA 2003
BP 73
EP 74
PG 2
WC Health Care Sciences & Services; Health Policy & Services; Public,
Environmental & Occupational Health
SC Health Care Sciences & Services; Public, Environmental & Occupational
Health
GA V38QW
UT WOS:000209358900205
ER
PT J
AU Meadan, H
Halle, JW
Kelly, SM
AF Meadan, Hedda
Halle, James W.
Kelly, Stacy M.
TI Intentional Communication of Young Children with Autism Spectrum
Disorder: Judgments of Different Communication Partners
SO JOURNAL OF DEVELOPMENTAL AND PHYSICAL DISABILITIES
LA English
DT Article
DE Intentional communication; Autism spectrum disorder; Communication
partners
ID PROFOUND MENTAL-RETARDATION; DEVELOPMENTAL-DISABILITIES; LANGUAGE;
INFANTS; ACQUISITION; BEHAVIOR
AB The purpose of this study was to examine judgments made by different listeners of the communicative intent, specifically requesting and rejecting, of young children with autism and limited expressive language. Video clips from a structured assessment study of three young children with autism spectrum disorder were edited and viewed by adult raters from four subgroups. Analysis of the findings indicated that those who were both familiar and expert were more accurate and more confident in their judgments than those who were unfamiliar and non-expert. There was more variation among the four subgroups of raters in accuracy related to rejecting compared to requesting behavior. It was concluded that collaboration in the determination of intention and consistency of responding to specific communicative forms among all individuals who are involved in the child's life appear to be important steps in developing common communication goals.
C1 [Meadan, Hedda; Kelly, Stacy M.] Illinois State Univ, Normal, IL 61761 USA.
[Halle, James W.] Univ Illinois, Champaign, IL 61820 USA.
RP Meadan, H (reprint author), Illinois State Univ, Normal, IL 61761 USA.
EM hmeadan@ilstu.edu
CR ADAMSON LB, 1987, DEV PSYCHOL, V23, P383, DOI 10.1037//0012-1649.23.3.383
Baird S. M., 1998, TRANSDISCIPLINARY J, V8, P149
Baird S. M., 1997, J VISUAL IMPAIRMENT, V91, P467
Bates E., 1979, EMERGENCE SYMBOLS CO
BATES E, 1975, MERRILL PALMER QUART, V21, P205
Brady N. C., 1997, FOCUS AUTISM OTHER D, V12, P95
Brady NC, 2004, J SPEECH LANG HEAR R, V47, P663, DOI 10.1044/1092-4388(2004/051)
CARPENTER RL, 1983, LANG SPEECH, V26, P101
Carter M., 2002, AUGMENTATIVE ALTERNA, V18, P177, DOI 10.1080/07434610212331281261
CIRRIN FM, 1985, MENT RETARD, V23, P52
Crais ER, 2009, AM J SPEECH-LANG PAT, V18, P95, DOI 10.1044/1058-0360(2008/07-0041)
Cress CJ, 2004, TOP LANG DISORD, V24, P51
Halle J, 2007, TOP EARLY CHILD SPEC, V27, P49, DOI 10.1177/02711214070270010401
HARDING CG, 1979, CHILD DEV, V50, P33, DOI 10.1111/j.1467-8624.1979.tb02976.x
Iacono T., 1998, AUGMENTATIVE ALTERNA, V14, P102, DOI DOI 10.1080/07434619812331278246
Keen D, 2005, J DEV PHYS DISABIL, V17, P19, DOI 10.1007/s10882-005-2198-5
LITTLE KB, 1961, EDUC PSYCHOL MEAS, V21, P95, DOI 10.1177/001316446102100108
MacCathren R., 2000, FOCUS AUTISM DEV DIS, V15, P21
Mattews-Somerville R. C., 2005, COMMUNICATION DISORD, V26, P164, DOI 10.1177/15257401050260030501
MCLEAN JE, 1991, J SPEECH HEAR RES, V34, P294
OGLETREE BT, 1992, AM J MENT RETARD, V97, P186
Reichle J., 1998, TRANSITIONS PRELINGU, P417
Sigafoos J., 2002, COMMUNICATION DISORD, V23, P131, DOI 10.1177/15257401020230030201
Sigafoos J, 2000, COMMUNICATION DISORD, V21, P77, DOI 10.1177/152574010002100202
Tager-Flusberg H, 2009, J SPEECH LANG HEAR R, V52, P643, DOI 10.1044/1092-4388(2009/08-0136)
WETHERBY AM, 1988, J SPEECH HEAR RES, V31, P240
Wetherby A. M., 1989, SEMINARS SPEECH LANG, V10, P77, DOI 10.1055/s-0028-1082491
WILCOX MJ, 1990, J SPEECH HEAR DISORD, V55, P679
Yoder P., 1986, INFANT MENT HEALTH J, V7, P281
YODER PJ, 1988, AM J MENT RETARD, V93, P36
Yoder PJ, 1999, J EARLY INTERVENTION, V22, P126
NR 31
TC 1
Z9 1
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1056-263X
J9 J DEV PHYS DISABIL
JI J. Dev. Phys. Disabil.
PD OCT
PY 2012
VL 24
IS 5
BP 437
EP 450
DI 10.1007/s10882-012-9281-5
PG 14
WC Rehabilitation
SC Rehabilitation
GA 999WJ
UT WOS:000308345700002
ER
PT J
AU van der Meer, L
Didden, R
Sutherland, D
O'Reilly, MF
Lancioni, GE
Sigafoos, J
AF van der Meer, Larah
Didden, Robert
Sutherland, Dean
O'Reilly, Mark F.
Lancioni, Giulio E.
Sigafoos, Jeff
TI Comparing Three Augmentative and Alternative Communication Modes for
Children with Developmental Disabilities
SO JOURNAL OF DEVELOPMENTAL AND PHYSICAL DISABILITIES
LA English
DT Article
DE Augmentative and alternative communication; Developmental disabilities;
Manual sign; Picture-exchange; Speech-generating devices
ID SPEECH-GENERATING DEVICES; OF-THE-LITERATURE; PICTURE EXCHANGE;
SINGLE-SUBJECT; MANUAL SIGNS; SYSTEM PECS; AUTISM; INTERVENTIONS;
PREFERENCE; INDIVIDUALS
AB We compared acquisition, maintenance, and preference for three AAC modes in four children with developmental disabilities (DD). Children were taught to make general requests for preferred items (snacks or play) using a speech-generating device (SGD), picture-exchange (PE), and manual signs (MS). The effects of intervention were evaluated in a multiple-probe across participants and alternating-treatments design. Preference probes were also conducted to determine if children would choose one AAC mode more frequently than the others. During intervention, all four children learned to request using PE and the SGD, but only two also reached criteria with MS. For the AAC preference assessments, three participants chose the SGD most frequently, while the other participant chose PE most frequently. The results suggest that children's preference for different AAC modes can be assessed during the early stages of intervention and that their preferences may influence acquisition and maintenance of AAC-based requesting responses.
C1 [van der Meer, Larah] Victoria Univ Wellington, Sch Educ Psychol & Pedag, Wellington 6147, New Zealand.
[Didden, Robert] Radboud Univ Nijmegen, NL-6525 ED Nijmegen, Netherlands.
[Sutherland, Dean] Univ Canterbury, Christchurch 1, New Zealand.
[O'Reilly, Mark F.] Univ Texas Austin, Meadows Ctr Prevent Educ Risk, Austin, TX 78712 USA.
[Lancioni, Giulio E.] Univ Bari, Bari, Italy.
RP van der Meer, L (reprint author), Victoria Univ Wellington, Sch Educ Psychol & Pedag, POB 17-310, Wellington 6147, New Zealand.
EM larah.vandermeer@vuw.ac.nz
CR Adkins T., 2001, BEHAV ANAL TODAY, V2, P259
[Anonymous], 2006, GEB KIND, V1
Beck AR, 2008, EDUC TRAIN DEV DISAB, V43, P198
Beukelman D., 2005, AUGMENTATIVE ALTERNA, V3rd
Bock S., 2005, EDUC TRAIN DEV DISAB, V40, P268
Bondy A, 2001, BEHAV MODIF, V25, P725, DOI 10.1177/0145445501255004
Bondy A. S., 1994, FOCUS AUTISTIC BEHAV, V9, P1, DOI DOI 10.1177/108835769400900301
Cannella-Malone HI, 2009, AUGMENT ALTERN COMM, V25, P262, DOI 10.3109/07434610903384511
DeLeon IG, 1996, J APPL BEHAV ANAL, V29, P519, DOI 10.1901/jaba.1996.29-519
Duker P. C., 2004, ONE TO ONE TRAINING
Flippin M, 2010, AM J SPEECH-LANG PAT, V19, P178, DOI 10.1044/1058-0360(2010/09-0022)
Goldstein H, 2002, J AUTISM DEV DISORD, V32, P373, DOI 10.1023/A:1020589821992
Green V., 2008, EARLY CHILDHOOD ED I, P87
Gregory MK, 2009, J APPL BEHAV ANAL, V42, P399, DOI 10.1901/jaba.2009.42-399
Hart SL, 2010, REM SPEC EDUC, V31, P476, DOI 10.1177/0741932509338354
Iacono T., 1993, AUGMENTATIVE ALTERNA, V9, P83, DOI DOI 10.1080/07434619312331276471
Iacono T. A., 1995, AUGMENTATIVE ALTERNA, V11, P249, DOI 10.1080/07434619512331277389
van der Meer Larah, 2011, Journal of Special Education Technology, V26
Kagohara D. M., 2010, CLIN CASE STUDIES, V9, P328, DOI DOI 10.1177/1534650110379633
Kennedy C, 2005, SINGLE CASE DESIGNS
Koul RK, 2001, FOCUS AUTISM OTHER D, V16, P162, DOI 10.1177/108835760101600304
Lancioni GE, 2007, RES DEV DISABIL, V28, P468, DOI 10.1016/j.ridd.2006.06.003
Light JC, 1998, J COMMUN DISORD, V31, P153, DOI 10.1016/S0021-9924(97)00087-7
Lloyd LL, 1997, AUGMENTATIVE ALTERNA
Mirenda P, 2003, LANG SPEECH HEAR SER, V34, P203, DOI 10.1044/0161-1461(2003/017)
Preston D, 2009, J AUTISM DEV DISORD, V39, P1471, DOI 10.1007/s10803-009-0763-y
Pyramid Educational Products, 2009, PICS PECS 2009
Ringdahl JE, 2009, RES DEV DISABIL, V30, P330, DOI 10.1016/j.ridd.2008.06.002
Rispoli MJ, 2010, DEV NEUROREHABIL, V13, P276, DOI 10.3109/17518421003636794
ROTHOLZ DA, 1989, J ASSOC PERS SEVERE, V14, P227
Schlosser R., 2008, EFFECTIVE PRACTICES, P325
Schlosser R. W., 2003, EFFICACY AUGMENTATIV
Schlosser RW, 2008, AM J SPEECH-LANG PAT, V17, P212, DOI 10.1044/1058-0360(2008/021)
Schlosser RW, 2006, RES DEV DISABIL, V27, P1, DOI 10.1016/j.ridd.2004.04.004
Sigafoos J., 2005, TECHNOLOGY DISABILIT, V17, P1
Sigafoos J, 2009, AUGMENT ALTERN COMM, V25, P99, DOI 10.1080/07434610902739959
Sigafoos J, 2006, Pediatr Rehabil, V9, P1, DOI 10.1080/13638490500293341
Sigafoos J, 2003, EFFICACY AUGMENTATIV, P323
Sigafoos J, 1998, ANTECEDENT CONTROL, P187
Son Seung-Hyun, 2006, Pediatr Rehabil, V9, P389, DOI 10.1080/13638490500519984
SOTO G, 1993, EDUC TRAIN MENT RET, V28, P169
Sparrow S., 2003, VINELAND Z ADAPTIVE
Sulzer-Azaroff B, 2009, FOCUS AUTISM DEV DIS, V24, P89, DOI 10.1177/1088357609332743
Tien K, 2008, EDUC TRAIN DEV DISAB, V43, P67
Tincani M., 2004, FOCUS AUTISM OTHER D, V19, P152, DOI DOI 10.1177/10883576040190030301
van der Meer L., 2012, RES DEV DISABILITIES
van der Meer L, 2011, RES DEV DISABIL, V32, P1422, DOI 10.1016/j.ridd.2011.02.003
van der Meer LAJ, 2010, DEV NEUROREHABIL, V13, P294, DOI 10.3109/17518421003671494
Wendt O., 2009, AUTISM SPECTRUM DISO, P83
Winborn-Kemmerer L, 2009, J APPL BEHAV ANAL, V42, P185, DOI 10.1901/jaba.2009.42-185
NR 50
TC 18
Z9 18
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1056-263X
J9 J DEV PHYS DISABIL
JI J. Dev. Phys. Disabil.
PD OCT
PY 2012
VL 24
IS 5
BP 451
EP 468
DI 10.1007/s10882-012-9283-3
PG 18
WC Rehabilitation
SC Rehabilitation
GA 999WJ
UT WOS:000308345700003
ER
PT J
AU Mechling, L
Ayres, KM
Purrazzella, K
Purrazzella, K
AF Mechling, Linda
Ayres, Kevin M.
Purrazzella, Kimberly
Purrazzella, Kaitlin
TI Evaluation of the Performance of Fine and Gross Motor Skills within
Multi-Step Tasks by Adults with Moderate Intellectual Disability when
Using Video Models
SO JOURNAL OF DEVELOPMENTAL AND PHYSICAL DISABILITIES
LA English
DT Article
DE Video modeling; Fine motor; Gross motor; Adults; Moderate intellectual
disability
ID AUTISM SPECTRUM DISORDERS; DAILY LIVING SKILLS; OF-THE-LITERATURE;
DEVELOPMENTAL-DISABILITIES; INDIVIDUALS; INTERVENTIONS; INSTRUCTION;
CHILDREN; SELF
AB The purpose of this study was to evaluate the effects of video modeling on the performance of fine and gross motor skills comprising multi-step tasks. Six home living tasks, which included both fine and gross motor skills, were included in the study and were completed by four adults with moderate intellectual disability. A multiple probe design across behaviors was used to assess performance across three sets of skills with four participants. Results showed there were minimal differences between performances on the two types of skills; however, individual differences did occur and overall the participants performed a greater percentage of fine motor skills independently correct. Implications are presented for considering not only the motor requirements of tasks presented through video models, but also the cognitive and visual processing demands of tasks.
EM mechlingl@uncw.edu
CR Ayres Kevin M., 2007, Journal of Special Education Technology, V22
Ayres K. M., 2010, SINGLE SUBJECT RES M, P329
Ayres KM, 2005, EDUC TRAIN DEV DISAB, V40, P183
Bellini S, 2007, EXCEPT CHILDREN, V73, P264
Biederman G B, 1999, Downs Syndr Res Pract, V6, P12, DOI 10.3104/reports.93
Cannella-Malone H, 2006, EDUC TRAIN DEV DISAB, V41, P344
Cannella-Malone HI, 2011, J POSIT BEHAV INTERV, V13, P144, DOI 10.1177/1098300710366593
Cihak David F, 2008, Journal of Special Education Technology, V23
Delano ME, 2007, REM SPEC EDUC, V28, P33, DOI 10.1177/07419325070280010401
Gast D. L, 2010, SINGLE SUBJECT RES M
Hermansen E, 2007, ED TREATMENT CHILDRE, V30, P183, DOI DOI 10.1353/ETC.2007.0029
Mechling L., 2005, Journal of Special Education Technology, V20
Mechling L. C., 2012, J SPECIAL ED TECHNOL, V27
Mechling L. C., 2012, J SPECIAL ED, DOI 0022466911433859
Mechling L. C., 2012, J AUTISM DEV DISABIL, DOI [10.1077/s10803-012-1484-1, DOI 10.1077/S10803-012-1484-1]
Mechling LC, 2012, EDUC TRAIN AUTISM DE, V47, P223
Rayner C, 2009, RES AUTISM SPECT DIS, V3, P291, DOI 10.1016/j.rasd.2008.09.001
Shukla-Mehta S, 2010, FOCUS AUTISM DEV DIS, V25, P23, DOI 10.1177/1088357609352901
Sparrow S, 1984, VINELAND ADAPTIVE BE
Taber-Doughty Teresa, 2008, Journal of Special Education Technology, V23
Thorndike RL, 1986, STANFORD BINET INTEL
Van Laarhoven T, 2009, EDUC TRAIN DEV DISAB, V44, P509
Wechsler D, 1977, WECHSLER ADULT INTEL
NR 23
TC 3
Z9 3
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1056-263X
J9 J DEV PHYS DISABIL
JI J. Dev. Phys. Disabil.
PD OCT
PY 2012
VL 24
IS 5
BP 469
EP 486
DI 10.1007/s10882-012-9284-2
PG 18
WC Rehabilitation
SC Rehabilitation
GA 999WJ
UT WOS:000308345700004
ER
PT J
AU Matson, JL
Hattier, MA
Turygin, N
AF Matson, Johnny L.
Hattier, Megan A.
Turygin, Nicole
TI An Evaluation of Social Skills in Adults with Pica, Autism Spectrum
Disorders, and Intellectual Disability
SO JOURNAL OF DEVELOPMENTAL AND PHYSICAL DISABILITIES
LA English
DT Article
DE Pica; Autism; Intellectual disability; Adults
ID SEVERE RETARDATION MESSIER; MENTAL-RETARDATION; DEVELOPMENTAL DISORDERS;
MALADAPTIVE BEHAVIORS; MATSON EVALUATION; PDD-NOS; INDIVIDUALS;
CHILDREN; PSYCHOPATHOLOGY; EPIDEMIOLOGY
AB Adults with intellectual disability (ID) and autism spectrum disorders (ASDs) are often at risk for developing additional forms of psychopathology and/or challenging behaviors, including pica. The aim of this study was to examine the relationship of pica and social skills deficits. The Matson Evaluation of Social Skills for Individuals with sEvere Retardation (MESSIER), a measure of social skill impairment, was administered to a group of adults with ID alone (n = 22), a group with ID and ASD (n = 22), and a group with ID, ASD, and pica (n = 15). The Pica + ASD + ID group exhibited significantly fewer pro-social behaviors than the ID alone group but had significantly more negative social skills than both other groups. These findings and the implications of these data are discussed.
C1 [Matson, Johnny L.; Hattier, Megan A.; Turygin, Nicole] Louisiana State Univ, Dept Psychol, Baton Rouge, LA 70803 USA.
RP Matson, JL (reprint author), Louisiana State Univ, Dept Psychol, 236 Audubon Hall, Baton Rouge, LA 70803 USA.
EM johnmatson@aol.com; mhatti1@tigers.lsu.edu; nturyg1@tigers.lsu.edu
CR Ashworth M, 2008, J MENT HEALTH RES IN, V1, P176, DOI 10.1080/19315860802029154
Ashworth M, 2009, RES DEV DISABIL, V30, P512, DOI 10.1016/j.ridd.2008.07.010
Baker D., 2005, BRIT DENT J, V199, P271
Barrett R. P., 2008, BROWN U CHILD ADOLES, V24, P1
Bodfish JW, 2000, J AUTISM DEV DISORD, V30, P237, DOI 10.1023/A:1005596502855
Brosnan J, 2011, RES DEV DISABIL, V32, P437, DOI 10.1016/j.ridd.2010.12.023
CALABRESE EJ, 1992, REGUL TOXICOL PHARM, V15, P83, DOI 10.1016/0273-2300(92)90086-O
Cappadocia MC, 2011, RES AUTISM SPECT DIS, V5, P70, DOI 10.1016/j.rasd.2010.04.001
Cherry KE, 1997, AM J MENT RETARD, V101, P445
Choure J, 2006, PSYCHOSOMATICS, V47, P531, DOI 10.1176/appi.psy.47.6.531
Chowdhury M, 2011, RES DEV DISABIL, V32, P383, DOI 10.1016/j.ridd.2010.11.015
Cook F, 2011, RES DEV DISABIL, V32, P11, DOI 10.1016/j.ridd.2010.09.021
Cooper M. D., 2010, ACCESS, V24, P39
Danford D. E., 1982, AM J MENT DEFIC, V127, P960
DECKER CJ, 1993, CAN J SURG, V36, P551
Deckers SRJM, 2011, RES DEV DISABIL, V32, P630, DOI 10.1016/j.ridd.2010.12.009
Fombonne E, 1999, PSYCHOL MED, V29, P769, DOI 10.1017/S0033291799008508
Fombonne E, 2005, J APPL RES INTELLECT, V18, P281, DOI 10.1111/j.1468-3148.2005.00266.x
FOVEL JT, 1989, RES DEV DISABIL, V10, P377, DOI 10.1016/0891-4222(89)90038-3
Gonyea Janelle, 2007, Nephrol Nurs J, V34, P230
GREENBERG M, 1958, PEDIATRICS, V22, P756
Hagopian LP, 2011, RES DEV DISABIL, V32, P2114, DOI 10.1016/j.ridd.2011.07.042
Hardan A, 1997, RES DEV DISABIL, V18, P369, DOI 10.1016/S0891-4222(97)00016-4
Hattier MA, 2012, RES AUTISM SPECT DIS, V6, P871, DOI 10.1016/j.rasd.2011.12.001
Kamal I, 1999, CAN J SURG, V42, P201
Kerr MP, 2009, EPILEPSY BEHAV, V15, pS26, DOI 10.1016/j.yebeh.2009.03.020
LACEY EP, 1990, PUBLIC HEALTH REP, V105, P29
La Malfa G, 2004, J INTELL DISABIL RES, V48, P262, DOI 10.1111/j.1365-2788.2003.00567.x
Levy A., 2011, RES AUTISM SPECT DIS, V5, P1413
LoVullo SV, 2009, RES DEV DISABIL, V30, P1288, DOI 10.1016/j.ridd.2009.05.004
MACE FC, 1986, J APPL BEHAV ANAL, V19, P411, DOI 10.1901/jaba.1986.19-411
Matson J. L., 2008, J INTELLECT DEV DIS, V33, P313
Matson J. L., PICA PERSON IN PRESS
Matson JL, 2005, RES DEV DISABIL, V26, P41, DOI 10.1016/j.ridd.2004.09.001
Matson JL, 2011, RES AUTISM SPECT DIS, V5, P1319, DOI 10.1016/j.rasd.2011.03.006
Matson J. L., 1995, MATSON EVALUATION SO
Matson J. L., 2011, RES AUTISM SPECT DIS, V5, P448
Matson JL, 2008, RES DEV DISABIL, V29, P341, DOI 10.1016/j.ridd.2007.06.006
Matson JL, 2008, RES DEV DISABIL, V29, P141, DOI 10.1016/j.ridd.2007.02.001
Matson JL, 1998, RES DEV DISABIL, V19, P493, DOI 10.1016/S0891-4222(98)00020-1
Matson JL, 2011, RES AUTISM SPECT DIS, V5, P1459, DOI 10.1016/j.rasd.2011.02.006
Matson JL, 2009, RES AUTISM SPECT DIS, V3, P258, DOI 10.1016/j.rasd.2008.07.001
Matson JL, 1999, J DEV PHYS DISABIL, V11, P353, DOI 10.1023/A:1021870925227
Matson JL, 2009, RES DEV DISABIL, V30, P1107, DOI 10.1016/j.ridd.2009.06.003
Matson JL, 2009, RES DEV DISABIL, V30, P249, DOI 10.1016/j.ridd.2008.04.002
Matson JL, 1999, BEHAV MODIF, V23, P647, DOI 10.1177/0145445599234008
McClintock K, 2003, J INTELL DISABIL RES, V47, P405, DOI 10.1046/j.1365-2788.2003.00517.x
McKenzie K, 2011, RES DEV DISABIL, V32, P395, DOI 10.1016/j.ridd.2010.12.001
Njardvik U, 1999, J AUTISM DEV DISORD, V29, P287, DOI 10.1023/A:1022107318500
Rivet TT, 2011, RES AUTISM SPECT DIS, V5, P957, DOI 10.1016/j.rasd.2010.12.003
Rose E A, 2000, J Am Board Fam Pract, V13, P353
RUTTER M, 1971, J AUTISM CHILD SCHIZ, V1, P20, DOI 10.1007/BF01537740
Suzuki M, 2011, RES AUTISM SPECT DIS, V5, P1517, DOI 10.1016/j.rasd.2011.02.014
Swift I, 1999, BRIT J DEV DISABIL, V45, P111
TEWARI S, 1995, BRIT J DEV DISABIL, V41, P13
Williams DE, 2009, J APPL RES INTELLECT, V22, P210, DOI 10.1111/j.1468-3148.2008.00490.x
Wing L, 2011, RES DEV DISABIL, V32, P768, DOI 10.1016/j.ridd.2010.11.003
NR 57
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1056-263X
J9 J DEV PHYS DISABIL
JI J. Dev. Phys. Disabil.
PD OCT
PY 2012
VL 24
IS 5
BP 505
EP 514
DI 10.1007/s10882-012-9286-0
PG 10
WC Rehabilitation
SC Rehabilitation
GA 999WJ
UT WOS:000308345700006
ER
PT J
AU Hasanzadeh, E
Mohammadi, MR
Ghanizadeh, A
Rezazadeh, SA
Tabrizi, M
Rezaei, F
Akhondzadeh, S
AF Hasanzadeh, Elmira
Mohammadi, Mohammad-Reza
Ghanizadeh, Ahmad
Rezazadeh, Shams-Ali
Tabrizi, Mina
Rezaei, Farzin
Akhondzadeh, Shahin
TI A Double-Blind Placebo Controlled Trial of Ginkgo biloba Added to
Risperidone in Patients with Autistic Disorders
SO CHILD PSYCHIATRY & HUMAN DEVELOPMENT
LA English
DT Article
DE Autism; Ginkgo biloba; Clinical trial; Risperidone
ID ALTERNATIVE MEDICINE; PHARMACOLOGICAL-TREATMENT; SPECTRUM DISORDERS;
ABERRANT BEHAVIOR; CHILDREN; COMPLEMENTARY
AB Ginkgo biloba has been reported to affect the neurotransmitter system and to have antioxidant properties that could impact the pathogenesis of Autism Spectrum Disorder. Based on these studies, we decided to assess the effectiveness of Ginkgo biloba extract (Ginko T.D., Tolidaru, Iran) as an adjunctive agent to risperidone in the treatment of autism. Forty-seven outpatients with a DSM-IV-TR diagnosis of autism ages between 4 and 12 years were assigned to this double blinded clinical trial and were randomly divided into two groups. One group received risperidone plus Ginko T.D and the other received risperidone plus placebo. The dose of risperidone was 1-3 mg/day and the dose of Ginko T.D. was 80 mg/day for patients under 30 kg and 120 mg/day for patients above 30 kg. Patients were assessed using Aberrant Behavior Checklist-Community (ABC-C) rating scale and the side effect check list every 2 weeks until the endpoint. None of the 5 subscales of ABC-C rating scale showed significant differences between the two groups. Incidents of side effects were not significantly different between the two groups. Adding Ginkgo biloba to risperidone did not affect the treatment outcome of ADs. Nevertheless, further observations are needed to confirm this result.
C1 [Hasanzadeh, Elmira; Mohammadi, Mohammad-Reza; Akhondzadeh, Shahin] Univ Tehran Med Sci, Roozbeh Psychiat Hosp, Psychiat Res Ctr, Tehran 13337, Iran.
[Ghanizadeh, Ahmad] Shiraz Univ Med Sci, Hafez Hosp, Res Ctr Psychiat & Behav Sci, Shiraz, Iran.
[Rezazadeh, Shams-Ali] Inst Med Plants ACECR, Tehran, Iran.
[Tabrizi, Mina] Univ Tehran Med Sci, Dept Med Genet, Tehran, Iran.
[Rezaei, Farzin] Kurdistan Univ Med Sci, Qods Hosp, Sanandaj, Iran.
RP Akhondzadeh, S (reprint author), Univ Tehran Med Sci, Roozbeh Psychiat Hosp, Psychiat Res Ctr, S Kargar St, Tehran 13337, Iran.
EM s.akhond@neda.net
CR Akhondzadeh S, 1999, J CLIN PHARM THER, V24, P241, DOI 10.1046/j.1365-2710.1999.00231.x
Akhondzadeh S, 2010, PROG NEURO-PSYCHOPH, V34, P32, DOI 10.1016/j.pnpbp.2009.09.012
Akhondzadeh S, 2004, J CLIN PHARM THER, V29, P145, DOI 10.1111/j.1365-2710.2004.00546.x
Akhondzadeh S, 2008, CHILD PSYCHIAT HUM D, V39, P237, DOI 10.1007/s10578-007-0084-3
Akins RS, 2010, NEUROTHERAPEUTICS, V7, P307, DOI 10.1016/j.nurt.2010.05.002
AMAN MG, 1985, AM J MENT DEF, V89, P485
American Psychiatric Association, 2000, AM PSYCH ASS DIAGN S, V4th
Autism and Developmental Disabilities Monitoring Network Surveillance Year 2006 Principal Investigators Centers for Disease Control and Prevention, 2009, MMWR-MORBID MORTAL W, V58, P1
Beaubrun G, 2000, PSYCHIATR SERV, V51, P1130, DOI 10.1176/appi.ps.51.9.1130
Bent S, 2010, NEUROTHERAPEUTICS, V7, P232, DOI 10.1016/j.nurt.2010.05.011
Blankenship K, 2010, PEDIAT HLTH, V4, P375, DOI DOI 10.2217/PHE.10.45
Bolte S, 2003, NEUROEMBRYOLOGY, V2, P175, DOI 10.1159/000079404
DeFeudis F. V., 2000, Current Drug Targets, V1, P25, DOI 10.2174/1389450003349380
Hanson E, 2007, J AUTISM DEV DISORD, V37, P628, DOI 10.1007/s10803-006-0192-0
Itil TM, 1998, PSYCHOPHARMACOL BULL, V34, P391
Leskovec TJ, 2008, HARVARD REV PSYCHIAT, V16, P97, DOI 10.1080/10673220802075852
Levy SE, 2008, CHILD ADOL PSYCH CL, V17, P803, DOI 10.1016/j.chc.2008.06.004
LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
Maclennan KM, 2002, PROG NEUROBIOL, V67, P235, DOI 10.1016/S0301-0082(02)00015-1
Mohammadi MR, 2007, CURRENT DRUG THERAPY, V2, P97, DOI 10.2174/157488507780619095
Niederhofer H, 2009, PHYTOTHER RES, V23, P1645, DOI 10.1002/ptr.2778
Ratajczak HV, 2011, J IMMUNOTOXICOL, V8, P68, DOI 10.3109/1547691X.2010.545086
Rezaei V, 2010, PROG NEURO-PSYCHOPH, V34, P1269, DOI 10.1016/j.pnpbp.2010.07.005
Steyaert JG, 2008, EUR J PEDIATR, V167, P1091, DOI 10.1007/s00431-008-0764-4
West L, 2009, J PEDIATR HEALTH CAR, V23, P75, DOI 10.1016/j.pedhc.2008.12.001
NR 25
TC 8
Z9 8
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0009-398X
J9 CHILD PSYCHIAT HUM D
JI Child Psychiat. Hum. Dev.
PD OCT
PY 2012
VL 43
IS 5
BP 674
EP 682
DI 10.1007/s10578-012-0292-3
PG 9
WC Psychology, Developmental; Pediatrics; Psychiatry
SC Psychology; Pediatrics; Psychiatry
GA 993TW
UT WOS:000307883500002
PM 22392415
ER
PT J
AU Storch, EA
Arnold, EB
Jones, AM
Ale, CM
Wood, JJ
Ehrenreich-May, J
Lewin, AB
Mutch, PJ
Murphy, TK
AF Storch, Eric A.
Arnold, Elysse B.
Jones, Anna M.
Ale, Chelsea M.
Wood, Jeffrey J.
Ehrenreich-May, Jill
Lewin, Adam B.
Mutch, P. Jane
Murphy, Tanya K.
TI The Role of Co-Occurring Disruptive Behavior in the Clinical
Presentation of Children and Adolescents with Anxiety in the Context of
Autism Spectrum Disorders
SO CHILD PSYCHIATRY & HUMAN DEVELOPMENT
LA English
DT Article
DE Autism; Anxiety; Asperger's Syndrome; Comorbidity; Children;
Oppositional defiant disorder; Treatment; Assessment
ID OBSESSIVE-COMPULSIVE DISORDER; ATTENTION-DEFICIT/HYPERACTIVITY DISORDER;
PERVASIVE DEVELOPMENTAL DISORDERS; COMORBID ANXIETY; ASPERGER-SYNDROME;
CONTROLLED-TRIAL; IMPACT; ATOMOXETINE; SYMPTOMS; RELIABILITY
AB This study explored the impact of disruptive behavior disorder (DBD) comorbidity on theoretically relevant correlates among 87 children and adolescents with autism spectrum disorders (ASD) and clinically significant anxiety. Relative to youth with ASD and anxiety alone, participants with ASD, anxiety, and DBD: (a) presented with significantly more severe anxiety symptoms per clinician-, parent-, and self-report; (b) were more likely to be prescribed antipsychotic medication but were no more likely to receive additional psychosocial and educational interventions; and (c) experienced significantly greater functional impairment and family interference. These results suggest that co-occurring DBD in the context of ASD and anxiety confers greater risk for heightened symptom severity and functional impairment, and may be linked with increased prescription of antipsychotic medication.
C1 [Storch, Eric A.; Arnold, Elysse B.; Jones, Anna M.; Ale, Chelsea M.; Lewin, Adam B.; Mutch, P. Jane; Murphy, Tanya K.] Univ S Florida, Dept Pediat, Rothman Ctr Neuropsychiat, St Petersburg, FL 33701 USA.
[Storch, Eric A.; Lewin, Adam B.; Murphy, Tanya K.] Univ S Florida, Dept Psychiat & Neurosci, Tampa, FL USA.
[Wood, Jeffrey J.] Univ Calif Los Angeles, Dept Educ Psychol, Los Angeles, CA USA.
[Ehrenreich-May, Jill] Univ Miami, Dept Psychol, Coral Gables, FL 33124 USA.
RP Storch, EA (reprint author), Univ S Florida, Dept Pediat, Rothman Ctr Neuropsychiat, 800 6th St S,4th Floor N,Box 7523, St Petersburg, FL 33701 USA.
EM estorch@health.usf.edu
RI Storch, Eric/I-4935-2012; Lewin, Adam/A-9832-2013
CR Achenbach TM, 2001, MANUAL ASEBA SCH AGE
Almandil NB, 2011, ARCH DIS CHILDHOOD-E, V96, P192, DOI [10.1136/archdischild-192 2011-300054, 10.1136/archdischild-2011-300054]
Aman Michael G, 2004, Semin Pediatr Neurol, V11, P225, DOI 10.1016/j.spen.2004.07.006
(APA) APA, 2000, DIAGN STAT MAN MENT
Arnold LE, 2010, J CHILD ADOL PSYCHOP, V20, P83, DOI 10.1089/cap.2009.0022
Arnold LE, 2006, J AM ACAD CHILD PSY, V45, P1196, DOI 10.1097/01.chi.0000231976.28719.2a
Barkley R., 1997, DEFIANT CHILDREN CLI, V2nd
Barkley RA, 2002, DEV PSYCHOPATHOL, V14, P45, DOI 10.1017/S0954579402001037
Bird HR, 1996, INT J METHOD PSYCH, V6, P295, DOI 10.1002/(SICI)1234-988X(199612)6:4<295::AID-MPR173>3.3.CO;2-5
Brookman-Frazee L, 2006, CLIN CHILD FAM PSYCH, V9, P181, DOI 10.1007/s10567-006-0010-4
Brosnan J, 2011, RES DEV DISABIL, V32, P437, DOI 10.1016/j.ridd.2010.12.023
Bubier JL, 2009, CLIN PSYCHOL REV, V29, P658, DOI 10.1016/j.cpr.2009.08.005
Constantino JN, 2002, SOCIAL RESPONSIVENES
Correll CU, 2009, JAMA-J AM MED ASSOC, V302, P1765, DOI 10.1001/jama.2009.1549
de Bruin EI, 2007, J AUTISM DEV DISORD, V37, P877, DOI 10.1007/s10803-006-0215-x
Drabick DAG, 2008, J CLIN CHILD ADOLESC, V37, P314, DOI 10.1080/15374410801955862
Fischer M, 2005, DEV NEUROPSYCHOL, V27, P107, DOI 10.1207/s15326942dn2701_5
Gadow KD, 2008, J AUTISM DEV DISORD, V38, P1302, DOI 10.1007/s10803-007-0516-8
Garland AF, 2008, J AM ACAD CHILD PSY, V47, P505, DOI 10.1097/CHI.0b013e31816765c2
Geller DA, 2003, J CHILD ADOL PSYCHOP, V13, pS19
Goodman WK, 2007, PSYCHOPHARMACOLOGY, V191, P87, DOI 10.1007/s00213-006-0642-6
Green J, 2000, J AUTISM DEV DISORD, V30, P279, DOI 10.1023/A:1005523232106
GREENLAND S, 1987, AM J EPIDEMIOL, V125, P761
Kazdin Alan E, 2003, Evid Based Ment Health, V6, P81
Korenblum CB, 2007, DEPRESS ANXIETY, V24, P227, DOI 10.1002/da.20237
Langley AK, 2010, EUR CHILD ADOLES PSY, V19, P637, DOI 10.1007/s00787-010-0101-0
Langley AK, 2004, J CHILD ADOL PSYCHOP, V14, P105, DOI 10.1089/104454604773840544
Lecavalier L, 2006, J INTELL DISABIL RES, V50, P172, DOI 10.1111/j.1365-2788.2005.00732.x
Lewin AB, 2011, J DEV PHYS DISABIL, V23, P543, DOI 10.1007/s10882-011-9247-z
Lewin AB, 2010, JAMA-J AM MED ASSOC, V303, P729, DOI 10.1001/jama.2010.132
Leyfer OT, 2006, J AUTISM DEV DISORD, V36, P849, DOI 10.1007/s10803-006-0123-0
March JS, 1997, J AM ACAD CHILD PSY, V36, P554, DOI 10.1097/00004583-199704000-00019
Masse J. J., 2007, J EARLY INTENSIVE BE, V4, P714
Mattila ML, 2010, J AUTISM DEV DISORD, V40, P1080, DOI 10.1007/s10803-010-0958-2
Muris P, 1998, J ANXIETY DISORD, V12, P387, DOI 10.1016/S0887-6185(98)00022-X
Nadeau J, 2011, NEUROPSYCHIATRY-LOND, V1, P567, DOI 10.2217/NPY.11.62
National Institute of Mental Health, 1985, PSYCHOPHARMACOL BULL, V21, P839
Neuhut R, 2009, J CHILD ADOL PSYCHOP, V19, P415, DOI 10.1089/cap.2008.0130
Posey DJ, 2006, J CHILD ADOL PSYCHOP, V16, P599, DOI 10.1089/cap.2006.16.599
McCracken JT, 2002, NEW ENGL J MED, V347, P314, DOI 10.1056/NEJMoa013171
RUPP, 2002, J AM ACAD CHILD ADOL, V41, P1061
Silverman W. K., 1996, ANXIETY DISORDERS IN
Silverman WK, 2001, J AM ACAD CHILD PSY, V40, P937, DOI 10.1097/00004583-200108000-00016
Sofronoff K, 2005, J CHILD PSYCHOL PSYC, V46, P1152, DOI 10.1111/j.1469-7610.2005.00411.x
Storch EA, J AUTISM DE IN PRESS
Storch EA, 2008, J AM ACAD CHILD PSY, V47, P583, DOI 10.1097/CHI.0b013e31816774b1
Storch EA, 2010, BEHAV RES THER, V48, P1204, DOI 10.1016/j.brat.2010.09.004
Sze K. M., 2007, J CONTEMP PSYCHOTHER, V37, P133, DOI 10.1007/s10879-007-9048-y
Troost PW, 2006, J CHILD ADOL PSYCHOP, V16, P611, DOI 10.1089/cap.2006.16.611
van de Wiel N, 2002, EUR CHILD ADOLES PSY, V11, P79
White SW, 2009, CLIN PSYCHOL REV, V29, P216, DOI 10.1016/j.cpr.2009.01.003
Wood JJ, 2009, J CHILD PSYCHOL PSYC, V50, P224, DOI 10.1111/j.1469-7610.2008.01948.x
Wood JW, 2002, TLS-TIMES LIT SUPPL, P31
Zeiner P, 2011, ACTA PAEDIATR, V100, P1258, DOI 10.1111/j.1651-2227.2011.02263.x
NR 54
TC 6
Z9 6
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0009-398X
J9 CHILD PSYCHIAT HUM D
JI Child Psychiat. Hum. Dev.
PD OCT
PY 2012
VL 43
IS 5
BP 734
EP 746
DI 10.1007/s10578-012-0294-1
PG 13
WC Psychology, Developmental; Pediatrics; Psychiatry
SC Psychology; Pediatrics; Psychiatry
GA 993TW
UT WOS:000307883500005
PM 22407279
ER
PT J
AU Wong, N
Beidel, DC
Sarver, DE
Sims, V
AF Wong, Nina
Beidel, Deborah C.
Sarver, Dustin E.
Sims, Valerie
TI Facial Emotion Recognition in Children with High Functioning Autism and
Children with Social Phobia
SO CHILD PSYCHIATRY & HUMAN DEVELOPMENT
LA English
DT Article
DE Social skill deficits; Facial emotion recognition; Facial affect
recognition; High functioning autism; Social phobia
ID ASPERGER-SYNDROME; SPECTRUM DISORDERS; ANXIETY INVENTORY; DISCRIMINATIVE
VALIDITY; EXPRESSION RECOGNITION; EFFECTIVENESS THERAPY; BEHAVIORAL
TREATMENT; FACE RECOGNITION; SCHEMATIC FACES; SPAI-C
AB Recognizing facial affect is essential for effective social functioning. This study examines emotion recognition abilities in children aged 7-13 years with High Functioning Autism (HFA = 19), Social Phobia (SP = 17), or typical development (TD = 21). Findings indicate that all children identified certain emotions more quickly (e.g., happy < anger, disgust, sad < fear) and more accurately (happy) than other emotions (disgust). No evidence was found for negative interpretation biases in children with HFA or SP (i.e., all groups showed similar ability to discriminate neutral from non-neutral facial expressions). However, distinct between-group differences emerged when considering facial expression intensity. Specifically, children with HFA detected mild affective expressions less accurately than TD peers. Behavioral ratings of social effectiveness or social anxiety were uncorrelated with facial affect recognition abilities across children. Findings have implications for social skills treatment programs targeting youth with skill deficits.
C1 [Wong, Nina; Beidel, Deborah C.; Sarver, Dustin E.; Sims, Valerie] Univ Cent Florida, Dept Psychol, Orlando, FL 32816 USA.
RP Wong, N (reprint author), Univ Cent Florida, Dept Psychol, 4000 Cent Florida Blvd, Orlando, FL 32816 USA.
EM nwong@knights.ucf.edu; Deborah.Beidel@ucf.edu;
Dustin.Sarver@knights.ucf.edu; Valerie.Sims@ucf.edu
CR American Psychiatric Association, 2000, DSM 4 TR DIAGN STAT, VFourth
Arrais KC, 2010, J PSYCHIATR RES, V44, P535, DOI 10.1016/j.jpsychires.2009.11.003
Bal E, 2010, J AUTISM DEV DISORD, V40, P358, DOI 10.1007/s10803-009-0884-3
BARONCOHEN S, 1993, COGNITION EMOTION, V7, P507, DOI 10.1080/02699939308409202
Baron-Cohen S, 2004, J AUTISM DEV DISORD, V34, P163, DOI 10.1023/B:JADD.0000022607.19833.00
Battaglia M, 2004, J AM ACAD CHILD PSY, V43, P358, DOI 10.1097/01.chi.0000103177.91435.1b
Beidel D. C., 2007, SHY CHILDREN PHOBIC
BEIDEL DC, 1985, BEHAV RES THER, V23, P109, DOI 10.1016/0005-7967(85)90019-1
Beidel DC, 2000, BEHAV THER, V31, P75, DOI 10.1016/S0005-7894(00)80005-2
Beidel DC, 2011, COMPREHENSIVE UNPUB
BEIDEL DC, 1995, PSYCHOL ASSESSMENT, V7, P73, DOI 10.1037/1040-3590.7.1.73
Beidel DC, 2007, J PSYCHOPATHOL BEHAV, V29, P47, DOI 10.1007/s10862-006-9021-1
Beidel DC, 2006, BEHAV THER, V37, P416, DOI 10.1016/j.beth.2006.06.002
Beidel DC, 1999, J AM ACAD CHILD PSY, V38, P643, DOI 10.1097/00004583-199906000-00010
Beidel DC, 1996, PSYCHOL ASSESSMENT, V8, P235, DOI 10.1037/1040-3590.8.3.235
Bolte S, 2006, BEHAV NEUROSCI, V120, P211, DOI 10.1037/0735-7044.120.1.211
Boraston Z, 2007, J PHYSIOL-LONDON, V581, P893, DOI 10.1113/jphysiol.2007.133587
BRADLEY MM, 1994, J BEHAV THER EXP PSY, V25, P49, DOI 10.1016/0005-7916(94)90063-9
Campbell R, 2002, NEUROPSYCHOLOGIA, V40, P575, DOI 10.1016/S0028-3932(01)00164-6
Chen YP, 2002, BEHAV RES THER, V40, P677, DOI 10.1016/S0005-7967(01)00086-9
Coles ME, 2005, BEHAV RES THER, V43, P109, DOI 10.1016/j.brat.2003.12.001
Corden B, 2008, NEUROPSYCHOLOGIA, V46, P137, DOI 10.1016/j.neuropsychologia.2007.08.005
Durand K, 2007, J EXP CHILD PSYCHOL, V97, P14, DOI 10.1016/j.jecp.2006.12.001
Ekman P., 1976, PICTURES FACIAL AFFE
FEINBERG TE, 1986, ARCH GEN PSYCHIAT, V43, P276
Foa EB, 2000, J ANXIETY DISORD, V14, P501, DOI 10.1016/S0887-6185(00)00036-0
Fydrich T, 1998, BEHAV RES THER, V36, P995, DOI 10.1016/S0005-7967(98)00069-2
Gepner B, 2001, J AUTISM DEV DISORD, V31, P37, DOI 10.1023/A:1005609629218
Gilliam J., 2001, GILLIAM ASPERGERS DI
Grossman JB, 2000, J CHILD PSYCHOL PSYC, V41, P369, DOI 10.1017/S0021963099005466
Gur RC, 2002, J NEUROSCI METH, V115, P137, DOI 10.1016/S0165-0270(02)00006-7
Gur RE, 2002, AM J PSYCHIAT, V159, P1992, DOI 10.1176/appi.ajp.159.12.1992
Husted DS, 2006, PROG NEURO-PSYCHOPH, V30, P389, DOI 10.1016/j.pnpbp.2005.11.024
Jones CRG, 2011, J CHILD PSYCHOL PSYC, V52, P275, DOI 10.1111/j.1469-7610.2010.02328.x
Jones W, 2008, ARCH GEN PSYCHIAT, V65, P946, DOI 10.1001/archpsyc.65.8.946
Joseph RM, 2003, J CHILD PSYCHOL PSYC, V44, P529, DOI 10.1111/1469-7610.00142
Kaufman A. S., 2004, KAUFMAN BRIEF INTELL
Kleinhans NM, 2010, NEUROPSYCHOLOGIA, V48, P3665, DOI 10.1016/j.neuropsychologia.2010.07.022
Klin A, 2002, ARCH GEN PSYCHIAT, V59, P809, DOI 10.1001/archpsyc.59.9.809
Kolassa IT, 2006, BRAIN RES, V1118, P130, DOI 10.1016/j.brainres.2006.08.019
Kolassa IT, 2009, COGNITION EMOTION, V23, P69, DOI 10.1080/02699930801940461
Kolassa IT, 2007, COGNITION EMOTION, V21, P1721, DOI 10.1080/02699930701229189
Lacava PG, 2007, REM SPEC EDUC, V28, P174, DOI 10.1177/07419325070280030601
LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
Macintosh Kathleen, 2006, Autism, V10, P199, DOI 10.1177/1362361306062026
Mansell W, 1999, COGNITION EMOTION, V13, P673
Miller GA, 2001, J ABNORM PSYCHOL, V110, P40, DOI 10.1037//0021-843X.110.1.40
Miyahara M, 2007, CHILD PSYCHIAT HUM D, V38, P121, DOI 10.1007/s10578-007-0048-7
Miyahara M, 2010, RES AUTISM SPECT DIS, V4, P242, DOI 10.1016/j.rasd.2009.09.010
Mogg K, 2004, J ABNORM PSYCHOL, V113, P160, DOI 10.1037/0021-843X.113.1.160
Montagne Barbara, 2005, Cogn Process, V6, P136, DOI 10.1007/s10339-005-0050-6
Montagne Barbara, 2006, Cogn Neuropsychiatry, V11, P389, DOI 10.1080/13546800444000254
Montirosso R, 2010, SOC DEV, V19, P71, DOI 10.1111/j.1467-9507.2008.00527.x
NELSON CA, 1987, CHILD DEV, V58, P889, DOI 10.2307/1130530
Paul R, 2009, J AUTISM DEV DISORD, V39, P115, DOI 10.1007/s10803-008-0607-1
Phan KL, 2006, BIOL PSYCHIAT, V59, P424, DOI 10.1016/j.biopsych.2005.08.012
Pishyar R, 2004, ANXIETY STRESS COPIN, V17, P23, DOI 10.1080/10615800310001601458
Rump KM, 2009, CHILD DEV, V80, P1434, DOI 10.1111/j.1467-8624.2009.01343.x
Rutter M, 1995, AUTISTIC DIAGNOSTIC
Saavedra LM, 2010, J CHILD PSYCHOL PSYC, V51, P924, DOI 10.1111/j.1469-7610.2010.02242.x
Scharfstein LA, 2011, J ABNORM CHILD PSYCH, V39, P865, DOI 10.1007/s10802-011-9498-2
Schneider F, 2006, AM J PSYCHIAT, V163, P442, DOI 10.1176/appi.ajp.163.3.442
Schwenck C, 2012, J CHILD PSYCHOL PSYC, V53, P651, DOI 10.1111/j.1469-7610.2011.02499.x
Semrud-Clikeman M, 2010, J ABNORM CHILD PSYCH, V38, P509, DOI 10.1007/s10802-009-9380-7
Shriberg LD, 2001, J SPEECH LANG HEAR R, V44, P1097, DOI 10.1044/1092-4388(2001/087)
Silver M, 2001, AUTISM, V5, P299, DOI 10.1177/1362361301005003007
Silverman W. K., 1996, ANXIETY DISORDERS IN
Silverman WK, 2001, J AM ACAD CHILD PSY, V40, P937, DOI 10.1097/00004583-200108000-00016
Simonian SJ, 2001, CHILD PSYCHIAT HUM D, V32, P137, DOI 10.1023/A:1012298707253
Smith MJL, 2010, NEUROPSYCHOLOGIA, V48, P2777, DOI 10.1016/j.neuropsychologia.2010.03.008
Spence SH, 1999, J ABNORM PSYCHOL, V108, P211, DOI 10.1037//0021-843X.108.2.211
Spezio ML, 2007, J AUTISM DEV DISORD, V37, P929, DOI 10.1007/s10803-006-0232-9
Staugaard SR, 2010, CLIN PSYCHOL REV, V30, P669, DOI 10.1016/j.cpr.2010.05.001
Tardif C, 2007, J AUTISM DEV DISORD, V37, P1469, DOI 10.1007/s10803-006-0223-x
Teunisse JP, 2001, CHILD NEUROPSYCHOL, V7, P1, DOI 10.1076/chin.7.1.1.3150
Thomas LA, 2007, DEVELOPMENTAL SCI, V10, P547, DOI 10.1111/j.1467-7687.2007.00614.x
Tracy JL, 2011, J AUTISM DEV DISORD, V41, P102, DOI 10.1007/s10803-010-1030-y
TURNER SM, 1994, BEHAV RES THER, V32, P381, DOI 10.1016/0005-7967(94)90001-9
Widen SC, 2008, COGNITIVE DEV, V23, P291, DOI 10.1016/j.cogdev.2008.01.002
WINTON EC, 1995, BEHAV RES THER, V33, P193, DOI 10.1016/0005-7967(94)E0019-F
Wolf JM, 2008, AUTISM RES, V1, P329, DOI 10.1002/aur.56
Wood JW, 2002, TLS-TIMES LIT SUPPL, P31
Yoon KL, 2007, BEHAV RES THER, V45, P839, DOI 10.1016/j.brat.2006.05.004
NR 83
TC 5
Z9 7
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0009-398X
J9 CHILD PSYCHIAT HUM D
JI Child Psychiat. Hum. Dev.
PD OCT
PY 2012
VL 43
IS 5
BP 775
EP 794
DI 10.1007/s10578-012-0296-z
PG 20
WC Psychology, Developmental; Pediatrics; Psychiatry
SC Psychology; Pediatrics; Psychiatry
GA 993TW
UT WOS:000307883500008
PM 22528028
ER
PT J
AU Kirsten, TB
Chaves-Kirsten, GP
Chaible, LM
Silva, AC
Martins, DO
Britto, LRG
Dagli, MLZ
Torrao, AS
Palermo-Neto, J
Bernardi, MM
AF Kirsten, Thiago B.
Chaves-Kirsten, Gabriela P.
Chaible, Lucas M.
Silva, Ana C.
Martins, Daniel O.
Britto, Luiz R. G.
Dagli, Maria L. Z.
Torrao, Andrea S.
Palermo-Neto, Joao
Bernardi, Maria M.
TI Hypoactivity of the central dopaminergic system and autistic-like
behavior induced by a single early prenatal exposure to
lipopolysaccharide
SO JOURNAL OF NEUROSCIENCE RESEARCH
LA English
DT Article
DE animal model; autism-like effects; dopamine; gestation; infection
ID PERVASIVE DEVELOPMENTAL DISORDERS; IMMUNE CHALLENGE; BRAIN-INJURY;
ULTRASONIC VOCALIZATION; SPECTRUM DISORDERS; FETAL-BRAIN;
BACTERIAL-ENDOTOXIN; PARKINSONS-DISEASE; AMNIOTIC-FLUID; PRETERM BIRTH
AB The aim of the present study was to evaluate the behavioral patterns associated with autism and the prevalence of these behaviors in males and females, to verify whether our model of lipopolysaccharide (LPS) administration represents an experimental model of autism. For this, we prenatally exposed Wistar rats to LPS (100 mu g/kg, intraperitoneally, on gestational day 9.5), which mimics infection by gram-negative bacteria. Furthermore, because the exact mechanisms by which autism develops are still unknown, we investigated the neurological mechanisms that might underlie the behavioral alterations that were observed. Because we previously had demonstrated that prenatal LPS decreases striatal dopamine (DA) and metabolite levels, the striatal dopaminergic system (tyrosine hydroxylase [TH] and DA receptors D1a and D2) and glial cells (astrocytes and microglia) were analyzed by using immunohistochemistry, immunoblotting, and real-time PCR. Our results show that prenatal LPS exposure impaired communication (ultrasonic vocalizations) in male pups and learning and memory (T-maze spontaneous alternation) in male adults, as well as inducing repetitive/restricted behavior, but did not change social interactions in either infancy (play behavior) or adulthood in females. Moreover, although the expression of DA receptors was unchanged, the experimental animals exhibited reduced striatal TH levels, indicating that reduced DA synthesis impaired the striatal dopaminergic system. The expression of glial cell markers was not increased, which suggests that prenatal LPS did not induce permanent neuroinflammation in the striatum. Together with our previous finding of social impairments in males, the present findings demonstrate that prenatal LPS induced autism-like effects and also a hypoactivation of the dopaminergic system. (c) 2012 Wiley Periodicals, Inc.
C1 [Kirsten, Thiago B.; Chaible, Lucas M.; Silva, Ana C.; Dagli, Maria L. Z.; Palermo-Neto, Joao; Bernardi, Maria M.] Univ Sao Paulo, Dept Pathol, Sch Vet Med, BR-05508270 Sao Paulo, Brazil.
[Chaves-Kirsten, Gabriela P.; Martins, Daniel O.; Britto, Luiz R. G.; Torrao, Andrea S.] Univ Sao Paulo, Dept Physiol & Biophys, Inst Biomed Sci, BR-05508270 Sao Paulo, Brazil.
[Bernardi, Maria M.] Univ Estadual Paulista, Hlth Sci Inst, Sao Paulo, Brazil.
RP Kirsten, TB (reprint author), Univ Sao Paulo, Dept Pathol, Sch Vet Med, Av Prof Dr Orlando Marques de Paiva 87, BR-05508270 Sao Paulo, Brazil.
EM thik@hotmail.com
RI Torrao, Andrea/C-2353-2012; Chaible, Lucas/F-2403-2013; Celulas tronco,
Inct/I-1921-2013; Martins, Daniel/P-1145-2014
FU Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)
[08/53861-5, 09/51886-3]; Conselho Nacional de Desenvolvimento
Cientifico e Tecnologico (CNPq) [301739/2007-2]; Paulista University
[7-02-747/2010]
FX Contract grant sponsor: Fundacao de Amparo a Pesquisa do Estado de Sao
Paulo (FAPESP); Contract grant number: 08/53861-5; Contract grant
number: 09/51886-3; Contract grant sponsor: Conselho Nacional de
Desenvolvimento Cientifico e Tecnologico (CNPq); Contract grant number:
301739/2007-2; Contract grant sponsor: Paulista University; Contract
grant number: 7-02-747/2010.
CR Arndt TL, 2005, INT J DEV NEUROSCI, V23, P189, DOI 10.1016/j.ijdevneu.2004.11.001
Ashdown H, 2006, MOL PSYCHIATR, V11, P47, DOI 10.1038/sj.mp.4001748
Atladottir HO, 2010, J AUTISM DEV DISORD, V40, P1423, DOI 10.1007/s10803-010-1006-y
Baker H, 2003, CELL MOL NEUROBIOL, V23, P507, DOI 10.1023/A:1025015928129
Baker S, 2008, BRAIN RES, V1213, P98, DOI 10.1016/j.brainres.2008.03.035
Bambini V, 2011, BRAIN RES, V1408, P8, DOI 10.1016/j.brainres.2011.06.015
Boksa P, 2010, BRAIN BEHAV IMMUN, V24, P881, DOI 10.1016/j.bbi.2010.03.005
Brunelli SA, 1996, DEV PSYCHOBIOL, V29, P507, DOI 10.1002/(SICI)1098-2302(199609)29:6<507::AID-DEV3>3.0.CO;2-Q
Brunelli SA, 1997, DEV PSYCHOBIOL, V31, P255, DOI 10.1002/(SICI)1098-2302(199712)31:4<255::AID-DEV3>3.0.CO;2-Q
Burd I, 2012, AM J REPROD IMMUNOL, V67, P287, DOI 10.1111/j.1600-0897.2012.01110.x
Cai ZW, 2000, PEDIATR RES, V47, P64, DOI 10.1203/00006450-200001000-00013
Chaves GP, 2008, J NEUROSCI RES, V86, P1626, DOI 10.1002/jnr.21613
Meyer U, 2011, PEDIATR RES, V69, p26R, DOI 10.1203/PDR.0b013e318212c196
Dudchenko PA, 2004, NEUROSCI BIOBEHAV R, V28, P699, DOI 10.1016/j.neubiorev.2004.09.002
Dunn AJ, 2006, CLIN NEUROSCI RES, V6, P52, DOI 10.1016/j.cnr.2006.04.002
Fombonne E, 2009, PEDIATR RES, V65, P591, DOI 10.1203/PDR.0b013e31819e7203
Fortier ME, 2004, J PSYCHIAT RES, V38, P335, DOI 10.1016/j.jpsychires.2003.10.001
Gadia Carlos A, 2004, J Pediatr (Rio J), V80, pS83
Gayle DA, 2004, AM J PHYSIOL-REG I, V286, pR1024, DOI 10.1152/ajpregu.00664.2003
GUTTMAN M, 1992, NEUROL CLIN, V10, P377
Hava G, 2006, DEV PSYCHOBIOL, V48, P162, DOI 10.1002/dev.20116
Herbert MR, 2010, CURR OPIN NEUROL, V23, P103, DOI 10.1097/WCO.0b013e328336a01f
Huot P, 2007, J NEUROCHEM, V101, P1441, DOI 10.1111/j.1471-4159.2006.04430.x
INSEL TR, 1986, PHARMACOL BIOCHEM BE, V24, P1263, DOI 10.1016/0091-3057(86)90182-6
Ise S, 2008, BRAIN RES, V1234, P59, DOI 10.1016/j.brainres.2008.07.079
James SJ, 2008, CURR CLIN NEUROL, P245, DOI 10.1007/978-1-60327-489-0_11
Kanner L, 1943, NERV CHILD, V2, P217
Kirsten TB, 2010, NEUROIMMUNOMODULAT, V17, P240, DOI 10.1159/000290040
Kirsten TB, 2010, BEHAV BRAIN RES, V211, P77, DOI 10.1016/j.bbr.2010.03.009
Kirsten TB, 2011, PHYSIOL BEHAV, V104, P417, DOI 10.1016/j.physbeh.2011.04.049
Kirsten TB, 2008, THESIS U SAO PAULO S
Kreitzer AC, 2008, NEURON, V60, P543, DOI 10.1016/j.neuron.2008.11.005
Landrigan PJ, 2010, CURR OPIN PEDIATR, V22, P219, DOI 10.1097/MOP.0b013e328336eb9a
Larson SJ, 2001, BRAIN BEHAV IMMUN, V15, P371, DOI 10.1006/brbi.2001.0643
Larsson HJ, 2005, AM J EPIDEMIOL, V161, P916, DOI 10.1093/aje/kwi123
Lenczowski MJP, 1997, AM J PHYSIOL-REG I, V273, pR1870
Leong TYM, 2010, ADV ANAT PATHOL, V17, P404, DOI 10.1097/PAP.0b013e3181f8957c
Libbey JE, 2005, J NEUROVIROL, V11, P1, DOI 10.1080/13550280590900553
Ling ZD, 2002, MOVEMENT DISORD, V17, P116, DOI 10.1002/mds.10078
Livak KJ, 2001, METHODS, V25, P402, DOI 10.1006/meth.2001.1262
McGuire SO, 2001, EXP NEUROL, V169, P219, DOI 10.1006/exnr.2001.7688
Meyer U, 2007, NEUROSCIENTIST, V13, P241, DOI 10.1177/1073858406296401
Meyer U, 2012, NEUROPHARMACOLOGY, V62, P1308, DOI 10.1016/j.neuropharm.2011.01.009
Meyer U, 2008, BRAIN BEHAV IMMUN, V22, P469, DOI 10.1016/j.bbi.2007.09.012
Meyer U, 2006, BRAIN BEHAV IMMUN, V20, P378, DOI 10.1016/j.bbi.2005.11.003
Meyer U, 2006, J NEUROSCI, V26, P4752, DOI 10.1523/JNEUROSCI.0099-06.2006
Meyer U, 2009, NEUROSCI BIOBEHAV R, V33, P1061, DOI 10.1016/j.neubiorev.2009.05.001
Miller MT, 2005, INT J DEV NEUROSCI, V23, P201, DOI 10.1016/j.ijdevneu.2004.06.007
Mirenda P, 2010, J AUTISM DEV DISORD, V40, P1521, DOI 10.1007/s10803-010-1012-0
Moy SS, 2008, BEHAV BRAIN RES, V188, P178, DOI 10.1016/j.bbr.2007.10.029
Muhle R, 2004, PEDIATRICS, V113, pE472, DOI 10.1542/peds.113.5.e472
Nakasato A, 2008, BRAIN RES, V1193, P128, DOI 10.1016/j.brainres.2007.11.043
Narita M, 2010, NEUROSCI RES, V66, P2, DOI 10.1016/j.neures.2009.09.001
Narita N, 2002, PEDIATR RES, V52, P576, DOI 10.1203/01.PDR.0000028406.01104.76
PANKSEPP J, 1980, BEHAV NEURAL BIOL, V30, P197, DOI 10.1016/S0163-1047(80)91077-8
Pletnikov MV, 1999, BEHAV BRAIN RES, V100, P43, DOI 10.1016/S0166-4328(98)00111-9
Porritt MJ, 2000, LANCET, V356, P44, DOI 10.1016/S0140-6736(00)02437-5
Raineki C, 2009, NEUROSCIENCE, V159, P31, DOI 10.1016/j.neuroscience.2008.12.012
Romero E, 2010, MOL PSYCHIATR, V15, P372, DOI 10.1038/mp.2008.44
Romero R, 2007, SEMIN REPROD MED, V25, P21, DOI 10.1055/s-2006-956773
Samuelsson AM, 2006, AM J PHYSIOL-REG I, V290, pR1345, DOI 10.1152/ajpregu.00268.2005
Schneider T, 2008, PSYCHONEUROENDOCRINO, V33, P728, DOI 10.1016/j.psyneuen.2008.02.011
Shi LM, 2003, J NEUROSCI, V23, P297
Smith SEP, 2007, J NEUROSCI, V27, P10695, DOI 10.1523/JNEUROSCI.2178-07.2007
Spencer SJ, 2007, AM J PHYSIOL-REG I, V293, pR581, DOI 10.1152/ajpregu.00262.2007
Stangherlin EC, 2008, BRAIN RES, V1201, P106, DOI 10.1016/j.brainres.2008.01.061
Szatmari P, 2006, J CHILD PSYCHOL PSYC, V47, P582, DOI 10.1111/j.1469-7610.2005.01537.x
Taricano M, 2010, THESIS U SAO PAULO S
Theoharides TC, 2009, EXPERT OPIN PHARMACO, V10, P2127, DOI 10.1517/14656560903107789
Timofeeva OA, 2008, NEUROTOXICOL TERATOL, V30, P38, DOI 10.1016/j.ntt.2007.10.002
Urakubo A, 2001, SCHIZOPHR RES, V47, P27, DOI 10.1016/S0920-9964(00)00032-3
Volkmar FR, 2004, J CHILD PSYCHOL PSYC, V45, P135, DOI 10.1046/j.0021-9630.2003.00317.x
Wang XY, 2006, SEMIN FETAL NEONAT M, V11, P343, DOI 10.1016/j.siny.2006.04.002
Wing L, 2002, MENT RETARD DEV D R, V8, P151, DOI 10.1002/mrdd.10029
NR 74
TC 21
Z9 21
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0360-4012
J9 J NEUROSCI RES
JI J. Neurosci. Res.
PD OCT
PY 2012
VL 90
IS 10
BP 1903
EP 1912
DI 10.1002/jnr.23089
PG 10
WC Neurosciences
SC Neurosciences & Neurology
GA 986YO
UT WOS:000307383800004
PM 22714803
ER
PT J
AU Weiss, HR
Liu, X
Grewal, P
Chi, OZ
AF Weiss, Harvey R.
Liu, Xia
Grewal, Parneet
Chi, Oak Z.
TI Reduced effect of stimulation of AMPA receptors on cerebral O-2
consumption in a rat model of autism
SO NEUROPHARMACOLOGY
LA English
DT Article
DE Alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA);
Excitatory amino acids; Cerebral blood flow; Cerebral O-2 consumption;
Autism spectrum disorders; Rats
ID TUBEROUS SCLEROSIS COMPLEX; OXYGEN-CONSUMPTION; SPECTRUM DISORDERS;
INDUCED INCREASES; EKER RATS; IN-VIVO; GLUCOSE; INHIBITION; METABOLISM;
ISCHEMIA
AB Previous work demonstrated that basal alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor activity did not contribute to the elevated regional cerebral O-2 consumption in the brains of Eker rat (an autism-tuberous sclerosis model). We tested the hypothesis that increased stimulation of AMPA receptors also would not augment cerebral O-2 consumption in the Eker rat. Three cortical sites were prepared for administration of saline, 10(-4) and 10(-3) M AMPA in young (4 weeks) male control Long Evans and Eker rats (70-100 g). Cerebral blood flow (C-14-iodoantipyrine) and O-2 consumption (cryomicrospectrophotometry) were determined in isoflurane anesthetized rats. Receptor levels were studied through Western analysis of the GLuR1 subunit of the AMPA receptor. We found significantly increased cortical O-2 consumption (+33%) after 10(-4) M AMPA in control rats. The higher dose of AMPA did not further increase consumption. In the Eker rats, neither dose led to a significant increase in cortical O-2 consumption. Regional blood flow followed a similar pattern to oxygen consumption but cortical O-2 extraction did not differ. Cortical AMPA receptor protein levels were significantly reduced (-21%) in the Eker compared to control rats. Both O-2 consumption and blood flow were significantly elevated in the pons of the Eker rats compared to control. These data demonstrate a reduced importance of AMPA receptors in the control of cortical metabolism, related to reduced AMPA receptor protein, in the Eker rat. This suggests that increasing AMPA receptor activity may not be an effective treatment for children with autism spectrum disorders as they also have reduced AMPA receptor number. (C) 2012 Elsevier Ltd. All rights reserved.
C1 [Weiss, Harvey R.; Grewal, Parneet] Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Dept Physiol & Biophys, Piscataway, NJ 08854 USA.
[Liu, Xia; Chi, Oak Z.] Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Dept Anesthesia, Piscataway, NJ 08854 USA.
RP Weiss, HR (reprint author), Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Dept Physiol & Biophys, 675 Hoes Lane W, Piscataway, NJ 08854 USA.
EM hweiss@umdnj.edu
FU New Jersey Governor's Council for Medical Research and Treatment of
Autism
FX This work was supported, in part, by a grant from the New Jersey
Governor's Council for Medical Research and Treatment of Autism.
CR Aldred S, 2003, J AUTISM DEV DISORD, V33, P93, DOI 10.1023/A:1022238706604
Caesar K, 2008, J PHYSIOL-LONDON, V586, P1337, DOI 10.1113/jphysiol.2007.144154
Carlson GC, 2012, PHARMACOL BIOCHEM BE, V100, P850, DOI 10.1016/j.pbb.2011.02.003
Chi OZ, 1999, NEUROL RES, V21, P299
Chi OZ, 2003, EXP BRAIN RES, V148, P256, DOI 10.1007/s00221-002-1310-7
CHI OZ, 1991, CIRC RES, V69, P414
Corona JC, 2008, NEUROCHEM RES, V33, P1428, DOI 10.1007/s11064-007-9559-7
Cuthill DJ, 2006, EXP NEUROL, V200, P509, DOI 10.1016/j.expneurol.2006.03.021
Ehninger D, 2009, J INTELL DISABIL RES, V53, P838, DOI 10.1111/j.1365-2788.2009.01208.x
Ehninger D, 2011, TRENDS MOL MED, V17, P78, DOI 10.1016/j.molmed.2010.10.002
Engber TM, 1998, NEUROSCIENCE, V87, P905, DOI 10.1016/S0306-4522(98)00015-3
Ess Kevin C, 2006, Semin Pediatr Neurol, V13, P37, DOI 10.1016/j.spen.2006.01.009
Fowler JH, 2004, J CEREBR BLOOD F MET, V24, P1098, DOI 10.1097/01.WCB.0000138665.25305.7C
Gerlai R, 2004, DRUG DISCOV TODAY, V9, P366, DOI 10.1016/S1359-6446(04)03039-9
Happe F, 2008, NEUROPSYCHOL REV, V18, P287, DOI 10.1007/s11065-008-9076-8
Haznedar MM, 2006, AM J PSYCHIAT, V163, P1252, DOI 10.1176/appi.ajp.163.7.1252
Holmes GL, 2007, EPILEPSIA, V48, P617, DOI 10.1111/j.1528-1167.2007.01035.x
Hu-Lince D, 2005, AM J PHARMACOGENOMIC, V5, P233, DOI 10.2165/00129785-200505040-00004
Kaya M, 2002, BRAIN DEV-JPN, V24, P77, DOI 10.1016/S0387-7604(02)00006-2
Kenerson H, 2005, PEDIATR RES, V57, P67, DOI 10.1203/01.PDR.0000147727.878571.07
Lewis JC, 2004, J MED GENET, V41, P203, DOI 10.1136/jmg.2003.012757
Mizuno A, 2006, BRAIN RES, V1104, P160, DOI 10.1016/j.brainres.2006.05.064
Mottron L, 2006, J AUTISM DEV DISORD, V36, P27, DOI 10.1007/s10803-005-0040-7
Purcell AE, 2001, NEUROLOGY, V57, P1618
Roberts TP, 2011, BIOL PSYCHIAT
RUMSEY JM, 1985, ARCH GEN PSYCHIAT, V42, P448
Schmitz N, 2006, BIOL PSYCHIAT, V59, P7, DOI 10.1016/j.biopsych.2005.06.007
Tomita S, 2010, PHYSIOLOGY, V25, P41, DOI 10.1152/physiol.00033.2009
Vaks YK, 2003, NEUROL RES, V25, P754, DOI 10.1179/016164103101202129
Volkmar FR, 2003, LANCET, V362, P1133, DOI 10.1016/S0140-6736(03)14471-6
Waltereit R, 2006, J NEUROCHEM, V96, P407, DOI 10.1111/j.1471-4159.2005.03538.x
Waterhouse L, 2008, NEUROPSYCHOL REV, V18, P273, DOI 10.1007/s11065-008-9074-x
Weiss HR, 2009, BRAIN RES, V1294, P138, DOI 10.1016/j.brainres.2009.08.022
Weiss HR, 2002, BRAIN RES, V951, P177, DOI 10.1016/S0006-8993(02)03158-X
Weiss HR, 2008, INT J DEV NEUROSCI, V26, P517, DOI 10.1016/j.ijdevneu.2008.01.002
Weiss HR, 2007, J NEUROSCI RES, V85, P2512, DOI 10.1002/jnr.21378
Wiznitzer M, 2004, J CHILD NEUROL, V19, P675
Zeng LH, 2007, NEUROBIOL DIS, V28, P184, DOI 10.1016/j.nbd.2007.07.015
ZHU NH, 1991, AM J PHYSIOL, V260, pH626
NR 39
TC 1
Z9 1
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0028-3908
J9 NEUROPHARMACOLOGY
JI Neuropharmacology
PD OCT
PY 2012
VL 63
IS 5
BP 837
EP 841
DI 10.1016/j.neuropharm.2012.06.014
PG 5
WC Neurosciences; Pharmacology & Pharmacy
SC Neurosciences & Neurology; Pharmacology & Pharmacy
GA 996CC
UT WOS:000308060600008
PM 22722031
ER
PT J
AU Akgul, EM
AF Akgul, Esra Macaroglu
TI Are we ready for an inclusive classroom?: school administrators' and
teachers' perceptions of autism
SO ENERGY EDUCATION SCIENCE AND TECHNOLOGY PART B-SOCIAL AND EDUCATIONAL
STUDIES
LA English
DT Article
DE Autism; Developmental disorder; Special education; Teachers' perception;
Administrators' perception
ID EARLY-CHILDHOOD; EDUCATION; CHILDREN; SKILLS
AB Autism is defined as a pervasive developmental disorder which affects a child's communication, social interaction and behaviors. For some individuals oral communication is never established, because they can either not talk or refuse to talk. Education is the only proved way to help individuals with autism to cope with the social world around them; therefore besides their families, there need to be schools, administrators and teachers to help these individuals. The biggest problem about the education of individuals with autism is the lack of awareness in schools and in society at all. This paper includes a research study which investigates elementary school administrators' and teachers' perceptions on children with autism and their ways of handling the problems schooling. Results, based on data collected from one hundred seventeen administrators and teachers, indicate the present situation in the Anatolian side of Istanbul, Turkey. Although administrators and teachers both feel themselves insufficient in teaching and dealing with children with autism, they do not ask for help and in-service training about the issue. They argue that the necessity of extra payment need to be done for them if they include a child with autism in their classes.
C1 Yildiz Tekn Univ, Fac Educ, Istanbul, Turkey.
RP Akgul, EM (reprint author), Yildiz Tekn Univ, Fac Educ, Istanbul, Turkey.
EM emacaroglu@gmail.com
CR Alisinanoglu F, 2012, ENER EDUC SCI TECH-B, V4, P373
Aydin S, 2011, ENER EDUC SCI TECH-B, V3, P87
Beaudet AL, 2007, NAT MED, V13, P534, DOI 10.1038/nm0507-534
Brownell MT, 1999, TEACHER ED SPECIAL E, V22, P154, DOI DOI 10.1177/088840649902200303
Darica N, 2005, AUSTIM CHILDREN AUST
Gulay H, 2011, ENER EDUC SCI TECH-B, V3, P431
Inan HZ, 2011, ENER EDUC SCI TECH-B, V3, P47
Joshi I, 2009, J DEV DISABILITIES, V9, P1
Kabadayi A, 2012, ENER EDUC SCI TECH-B, V4, P365
Kaya Y, 2011, ENER EDUC SCI TECH-B, V3, P221
Kaya Y, 2011, ENER EDUC SCI TECH-B, V3, P253
Koegel RL, 2009, J AUSTIM DEV DISORDE
Koster M, 2009, INT J INCLUSIVE EDUC, V13, P117, DOI 10.1080/13603110701284680
Ministry of National Education, 2010, MEB MEVZ BANK
Ozguner H, 2011, ENER EDUC SCI TECH-B, V3, P369
Rosenberg RE, 2009, J AUTISM DEV DISORD, V39, P1099, DOI 10.1007/s10803-009-0723-6
Williams ME, 2009, J AUTISM DEV DISORD, V39, P660, DOI 10.1007/s10803-008-0668-1
Yumak N, 2010, PROCD SOC BEHV, V2, P910, DOI 10.1016/j.sbspro.2010.03.125
NR 18
TC 0
Z9 0
PU SILA SCIENCE
PI TRABZON
PA UNIV MAH,MEKAN SOK NO 24, TRABZON, 00000, TURKEY
SN 1308-7711
J9 ENER EDUC SCI TECH-B
JI Energy Educ. Sci. Technol.-Pt. B
PD OCT
PY 2012
VL 4
IS 4
BP 1925
EP 1934
PG 10
WC Education & Educational Research; Education, Scientific Disciplines
SC Education & Educational Research
GA 948LN
UT WOS:000304504800005
ER
PT J
AU Coutellier, L
Beraki, S
Ardestani, PM
Saw, NL
Shamloo, M
AF Coutellier, Laurence
Beraki, Simret
Ardestani, Pooneh Memar
Saw, Nay Lui
Shamloo, Mehrdad
TI Npas4: A Neuronal Transcription Factor with a Key Role in Social and
Cognitive Functions Relevant to Developmental Disorders
SO PLOS ONE
LA English
DT Article
ID MICE LACKING; DOPAMINE TRANSPORTER; PREPULSE INHIBITION; SYNAPSE
DEVELOPMENT; RECOGNITION MEMORY; PERIRHINAL CORTEX; SCHIZOPHRENIA;
HIPPOCAMPUS; EXPRESSION; BEHAVIOR
AB Npas4 is a transcription factor, which is highly expressed in the brain and regulates the formation and maintenance of inhibitory synapses in response to excitatory synaptic activity. A deregulation of the inhibitory-excitatory balance has been associated with a variety of human developmental disorders such as schizophrenia and autism. However, not much is known about the role played by inhibitory synapses and inhibitory pathways in the development of nervous system disorders. We hypothesized that alterations in the inhibitory pathways induced by the absence of Npas4 play a major role in the expression of the symptoms observed in psychiatric disorders. To test this hypothesis we tested mice lacking the transcription factor (Npas4 knock-out mice (Npas4-KO)) in a battery of behavioral assays focusing on general activity, social behaviors, and cognitive functions. Npas4-KO mice are hyperactive in a novel environment, spend less time exploring an unfamiliar ovariectomized female, spend more time avoiding an unfamiliar male during a first encounter, show higher social dominance than their WT littermates, and display pre-pulse inhibition, working memory, long-term memory, and cognitive flexibility deficits. These behavioral deficits may replicate schizophrenia-related symptomatology such as social anxiety, hyperactivity, and cognitive and sensorimotor gating deficits. Immunohistochemistry analyses revealed that Npas4 expression is induced in the hippocampus after a social encounter and that Npas4 regulates the expression of c-Fos in the CA1 and CA3 regions of the hippocampus after a cognitive task. Our results suggest that Npas4 may play a major role in the regulation of cognitive and social functions in the brain with possible implications for developmental disorders such as schizophrenia and autism.
C1 [Coutellier, Laurence; Beraki, Simret; Ardestani, Pooneh Memar; Saw, Nay Lui; Shamloo, Mehrdad] Stanford Univ, Sch Med, Behav & Funct Neurosci Lab, Palo Alto, CA 94304 USA.
RP Shamloo, M (reprint author), Stanford Univ, Sch Med, Behav & Funct Neurosci Lab, Palo Alto, CA 94304 USA.
EM mshamloo@stanford.edu
FU National Institute of Neurological Disorders and Stroke P30 center core
grant [NS069375-01A1]
FX This study was supported by National Institute of Neurological Disorders
and Stroke P30 center core grant (NS069375-01A1). The funders had no
role in study design, data collection and analysis, decision to publish,
or preparation of the manuscript.
CR Belforte JE, 2010, NAT NEUROSCI, V13, P76, DOI 10.1038/nn.2447
Benes FM, 1998, BIOL PSYCHIAT, V44, P88, DOI 10.1016/S0006-3223(98)00138-3
Benes FM, 2001, NEUROPSYCHOPHARMACOL, V25, P1, DOI 10.1016/S0893-133X(01)00225-1
Blundell J, 2009, GENES BRAIN BEHAV, V8, P114, DOI 10.1111/j.1601-183X.2008.00455.x
Braff DL, 2001, PSYCHOPHARMACOLOGY, V156, P234, DOI 10.1007/s002130100810
Breuillaud L, 2012, BIOL PSYCHI IN PRESS
Broadbent NJ, 2004, P NATL ACAD SCI USA, V101, P14515, DOI 10.1073/pnas.0406344101
Choleris E, 2001, NEUROSCI BIOBEHAV R, V25, P253
Eichler Sabrina A, 2008, Front Mol Neurosci, V1, P2, DOI 10.3389/neuro.02.002.2008
ENNACEUR A, 1988, BEHAV BRAIN RES, V31, P47, DOI 10.1016/0166-4328(88)90157-X
Enticott PG, 2008, PSYCHIAT RES, V157, P251, DOI 10.1016/j.psychres.2007.04.007
Fendt M, 2011, BEHAV BRAIN RES, V217, P1, DOI 10.1016/j.bbr.2010.09.022
Ferguson JN, 2000, NAT GENET, V25, P284, DOI 10.1038/77040
Franklin K.B.J., 2008, MOUSE BRAIN STEREOTA, V3rd
Freedman R, 2003, NEW ENGL J MED, V349, P1738
Gaffan EA, 2000, BEHAV NEUROSCI, V114, P18, DOI 10.1037/0735-7044.114.1.18
Gainetdinov RR, 2001, P NATL ACAD SCI USA, V98, P11047, DOI 10.1073/pnas.191353298
Gaspar PA, 2009, J NEUROCHEM, V111, P891, DOI 10.1111/j.1471-4159.2009.06325.x
Geyer MA, 2001, PSYCHOPHARMACOLOGY, V156, P117, DOI 10.1007/s002130100811
Giros B, 1996, NATURE, V379, P606, DOI 10.1038/379606a0
Gould GG, 2011, J NEUROCHEM, V116, P291, DOI 10.1111/j.1471-4159.2010.07104.x
Greer PL, 2008, NEURON, V59, P846, DOI 10.1016/j.neuron.2008.09.002
Guidotti G, 2012, NEUROPSYCHOPHARMACOL, V37, P746, DOI 10.1038/npp.2011.252
Gundersen HJG, 1999, J MICROSC-OXFORD, V193, P199, DOI 10.1046/j.1365-2818.1999.00457.x
Hammond RS, 2004, NEUROBIOL LEARN MEM, V82, P26, DOI 10.1016/j.nlm.2004.03.005
Heckers S, 1998, NAT NEUROSCI, V1, P318, DOI 10.1038/1137
Hines RM, 2008, J NEUROSCI, V28, P6055, DOI 10.1523/JNEUROSCI.0032-08.2008
Homberg JR, 2007, PSYCHOPHARMACOLOGY, V195, P175, DOI 10.1007/s00213-007-0895-8
Hussman JP, 2001, J AUTISM DEV DISORD, V31, P247, DOI 10.1023/A:1010715619091
Kalueff AV, 2010, NEUROSCI BIOBEHAV R, V34, P373, DOI 10.1016/j.neubiorev.2009.08.003
KIM JS, 1980, NEUROSCI LETT, V20, P379, DOI 10.1016/0304-3940(80)90178-0
Klar AJS, 2004, GENETICS, V167, P1833, DOI 10.1554/genetics.104.028217
Kubik S, 2007, LEARN MEMORY, V14, P758, DOI 10.1101/lm.698107
Lalonde R, 2002, NEUROSCI BIOBEHAV R, V26, P91, DOI 10.1016/S0149-7634(01)00041-0
Lewis DA, 2005, NAT REV NEUROSCI, V6, P312, DOI 10.1038/nrn1648
Lijam N, 1997, CELL, V90, P895, DOI 10.1016/S0092-8674(00)80354-2
Lin YX, 2008, NATURE, V455, P1198, DOI 10.1038/nature07319
LINDZEY G, 1961, NATURE, V191, P474, DOI 10.1038/191474a0
Machaalani R, 2002, BRAIN RES, V951, P293, DOI 10.1016/S0006-8993(02)03175-X
Mohn AR, 1999, CELL, V98, P427, DOI 10.1016/S0092-8674(00)81972-8
Morellini F, 2010, CEREB CORTEX, V20, P2712, DOI 10.1093/cercor/bhq017
Moser M, 2004, MOL BRAIN RES, V128, P141, DOI 10.1016/j.molbrainres.2004.06.023
Ooe N, 2004, MOL CELL BIOL, V24, P608, DOI 10.1128/MCB.24.2.608-616.2004
O'Tuathaigh CMP, 2007, NEUROSCIENCE, V147, P18, DOI 10.1016/j.neuroscience.2007.03.051
Raemaekers M, 2002, ARCH GEN PSYCHIAT, V59, P313, DOI 10.1001/archpsyc.59.4.313
Ramamoorthi K, 2011, SCIENCE, V334, P1669, DOI 10.1126/science.1208049
Rubenstein JLR, 2003, GENES BRAIN BEHAV, V2, P255, DOI 10.1046/j.1601-183X.2003.00037.x
Shamir A, 2012, J NEUROSCI, V32, P2988, DOI 10.1523/JNEUROSCI.1899-11.2012
Shamloo M, 2006, EUR J NEUROSCI, V24, P2705, DOI 10.1111/j.1460-9568.2006.05172.x
SHEPHERD JK, 1994, PSYCHOPHARMACOLOGY, V116, P56, DOI 10.1007/BF02244871
Thaker GK, 2001, NAT MED, V7, P667, DOI 10.1038/89040
WEST MJ, 1991, ANAT REC, V231, P482, DOI 10.1002/ar.1092310411
Xiang JZ, 1999, EUR J NEUROSCI, V11, P3715, DOI 10.1046/j.1460-9568.1999.00790.x
Yamada K, 2004, AM J MED GENET B, V127B, P11, DOI 10.1002/ajmg.b.20166
Yizhar O, 2011, NATURE, V477, P171, DOI 10.1038/nature10360
NR 55
TC 21
Z9 21
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD SEP 28
PY 2012
VL 7
IS 9
AR e46604
DI 10.1371/journal.pone.0046604
PG 13
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 022PZ
UT WOS:000309973900189
PM 23029555
ER
PT J
AU Steinberg, KM
Ramachandran, D
Patel, VC
Shetty, AC
Cutler, DJ
Zwick, ME
AF Steinberg, Karyn Meltz
Ramachandran, Dhanya
Patel, Viren C.
Shetty, Amol C.
Cutler, David J.
Zwick, Michael E.
TI Identification of rare X-linked neuroligin variants by massively
parallel sequencing in males with autism spectrum disorder
SO MOLECULAR AUTISM
LA English
DT Article
DE Autism spectrum disorder; Massively parallel DNA sequencing; Rare
variation; Evolutionary conservation
ID COPY-NUMBER VARIATION; DE-NOVO MUTATIONS; TRANSCRIPTION FACTOR BACH1;
GENOME-WIDE LINKAGE; MENTAL-RETARDATION; GENETIC-VARIATION; FINGER
PROTEIN; HAPLOTYPE MAP; TWIN PAIRS; ASSOCIATION
AB Background: Autism spectrum disorder (ASD) is highly heritable, but the genetic risk factors for it remain largely unknown. Although structural variants with large effect sizes may explain up to 15% ASD, genome-wide association studies have failed to uncover common single nucleotide variants with large effects on phenotype. The focus within ASD genetics is now shifting to the examination of rare sequence variants of modest effect, which is most often achieved via exome selection and sequencing. This strategy has indeed identified some rare candidate variants; however, the approach does not capture the full spectrum of genetic variation that might contribute to the phenotype.
Methods: We surveyed two loci with known rare variants that contribute to ASD, the X-linked neuroligin genes by performing massively parallel Illumina sequencing of the coding and noncoding regions from these genes in males from families with multiplex autism. We annotated all variant sites and functionally tested a subset to identify other rare mutations contributing to ASD susceptibility.
Results: We found seven rare variants at evolutionary conserved sites in our study population. Functional analyses of the three 3 ' UTR variants did not show statistically significant effects on the expression of NLGN3 and NLGN4X. In addition, we identified two NLGN3 intronic variants located within conserved transcription factor binding sites that could potentially affect gene regulation.
Conclusions: These data demonstrate the power of massively parallel, targeted sequencing studies of affected individuals for identifying rare, potentially disease-contributing variation. However, they also point out the challenges and limitations of current methods of direct functional testing of rare variants and the difficulties of identifying alleles with modest effects.
C1 [Steinberg, Karyn Meltz; Ramachandran, Dhanya; Patel, Viren C.; Shetty, Amol C.; Cutler, David J.; Zwick, Michael E.] Emory Univ, Sch Med, Dept Human Genet, Atlanta, GA 30322 USA.
[Steinberg, Karyn Meltz] Emory Univ, Grad Program Populat Biol Ecol & Evolut, Atlanta, GA 30322 USA.
[Steinberg, Karyn Meltz] Univ Washington, Dept Genome Sci, Seattle, WA 98195 USA.
RP Zwick, ME (reprint author), Emory Univ, Sch Med, Dept Human Genet, Whitehead Biomed Res Bldg,Suite 301, Atlanta, GA 30322 USA.
EM mzwick@emory.edu
FU NIH/NIMH and Gift Fund [MH076439]; Simons Foundation Autism Research
Initiative; Training Program in Human Disease Genetics [1T32MH087977];
PHS [UL1 RR025008]; Clinical and Translational Science Award program;
National Institutes of Health; National Center for Research Resource
FX This work was supported by the NIH/NIMH and Gift Fund (grant number:
MH076439, MEZ); the Simons Foundation Autism Research Initiative (MEZ);
and the Training Program in Human Disease Genetics (grant number:
1T32MH087977, DR). We gratefully acknowledge the resources provided by
the AGRE Consortium and the participating AGRE families. We thank
members of the Cutler and Zwick labs for comments on the manuscript,
Jennifer Mulle for discussion, Cheryl T Strauss for editing, and the
Emory-Georgia Research Alliance Genome Center (EGC), supported in part
by PHS Grant UL1 RR025008 from the Clinical and Translational Science
Award program, National Institutes of Health, National Center for
Research Resources, for performing the Illumina sequencing runs. The
ELLIPSE Emory High Performance Computing Cluster (EHPCC) was used for
data analysis and the Emory Custom Cloning Core Facility (CCCF)
generated constructs to our specifications for the expression analyses.
CR Allen-Brady K, 2010, MOL PSYCHIATR, V15, P1006, DOI 10.1038/mp.2009.42
Anney R, 2010, HUM MOL GENET, V19, P4072, DOI 10.1093/hmg/ddq307
Baron-Cohen S, 2009, PHILOS T R SOC B, V364, P1377, DOI 10.1098/rstb.2008.0337
Barton NH, 2002, NAT REV GENET, V3, P11, DOI 10.1038/nrg700
BARTON NH, 1989, ANNU REV GENET, V23, P337, DOI 10.1146/annurev.genet.23.1.337
Bennetto L, 2007, BIOL PSYCHIAT, V62, P1015, DOI 10.1016/j.biopsych.2007.04.019
Betancur C, 2011, BRAIN RES, V1380, P42, DOI 10.1016/j.brainres.2010.11.078
Bucan M, 2009, PLOS GENET, V5, DOI 10.1371/journal.pgen.1000536
Celestino-Soper PBS, 2011, HUM MOL GENET, V20, P4360, DOI 10.1093/hmg/ddr363
Christian SL, 2008, BIOL PSYCHIAT, V63, P1111, DOI 10.1016/j.biopsych.2008.01.009
Chung RH, 2011, MOL AUTISM, V2, DOI 10.1186/2040-2392-2-18
Collins SC, 2010, AM J MED GENET A, V152A, P2512, DOI 10.1002/ajmg.a.33626
Myers RM, 2011, PLOS BIOL, V9, DOI 10.1371/journal.pbio.1001046
Constantino JN, 2010, AM J PSYCHIAT, V167, P1349, DOI 10.1176/appi.ajp.2010.09101470
Daoud H, 2009, BIOL PSYCHIAT, V66, P906, DOI 10.1016/j.biopsych.2009.05.008
Dean C, 2006, TRENDS NEUROSCI, V29, P21, DOI 10.1016/j.tins.2005.11.003
Devlin B, 2012, CURR OPIN GENET DEV, V22, P229, DOI 10.1016/j.gde.2012.03.002
Devlin B, 2011, BRAIN RES, V1380, P78, DOI 10.1016/j.brainres.2010.11.026
Durand CM, 2007, NAT GENET, V39, P25, DOI 10.1038/ng1933
EmPrime, PRIM DES
FALCONER DS, 1967, ANN HUM GENET, V31, P1
Feng JN, 2006, NEUROSCI LETT, V409, P10, DOI 10.1016/j.neulet.2006.08.017
Ferrando-Miguel R, 2003, J NEURAL TRANSM-SUPP, P193
Fombonne E, 2003, JAMA-J AM MED ASSOC, V289, P87, DOI 10.1001/jama.289.1.87
Dreszer TR, 2012, NUCLEIC ACIDS RES, V40, pD918, DOI 10.1093/nar/gkr1055
Gargiulo G, 2009, DEV CELL, V16, P466, DOI 10.1016/j.devcel.2009.02.002
Gauthier J, 2009, AM J MED GENET B, V150B, P421, DOI 10.1002/ajmg.b.30822
Gauthier J, 2011, HUM GENET, V130, P563, DOI 10.1007/s00439-011-0975-z
Gauthier J, 2005, AM J MED GENET B, V132B, P74, DOI 10.1002/ajmg.b.30066
Geschwind DH, 2001, AM J HUM GENET, V69, P463, DOI 10.1086/321292
Girirajan S, 2011, PLOS GENET, V7, DOI 10.1371/journal.pgen.1002334
Glessner JT, 2009, NATURE, V459, P569, DOI 10.1038/nature07953
Haldane JBS, 1927, P CAMB PHILOS SOC, V23, P838
Hallmayer J, 2011, ARCH GEN PSYCHIAT, V68, P1095, DOI 10.1001/archgenpsychiatry.2011.76
Heintzman ND, 2009, NATURE, V459, P108, DOI 10.1038/nature07829
Israel MA, 2012, NATURE, V482, P216, DOI 10.1038/nature10821
Jamain S, 2003, NAT GENET, V34, P27, DOI 10.1038/ng1136
Kogan MD, 2009, PEDIATRICS, V124, P1395, DOI 10.1542/peds.2009-1522
Kruglyak L, 1999, NAT GENET, V22, P139, DOI 10.1038/9642
Kumar RA, 2008, HUM MOL GENET, V17, P628, DOI 10.1093/hmg/ddm376
Lam HYK, 2012, NAT BIOTECHNOL, V30, P78, DOI 10.1038/nbt.2065
Lander ES, 1996, SCIENCE, V274, P536, DOI 10.1126/science.274.5287.536
Laumonnier F, 2004, AM J HUM GENET, V74, P552, DOI 10.1086/382137
Lawson-Yuen A, 2008, EUR J HUM GENET, V16, P614, DOI 10.1038/sj.ejhg.5202006
Levy D, 2011, NEURON, V70, P886, DOI 10.1016/j.neuron.2011.05.015
Lichtenstein P, 2010, AM J PSYCHIAT, V167, P1357, DOI 10.1176/appi.ajp.2010.10020223
Mamanova L, 2010, NAT METHODS, V7, P111, DOI 10.1038/nmeth.1419
Marshall CR, 2008, AM J HUM GENET, V82, P477, DOI 10.1016/j.ajhg.2007.12.009
Matys V, 2003, NUCLEIC ACIDS RES, V31, P374, DOI 10.1093/nar/gkg108
Mitchell AA, 2005, GENOME RES, V15, P960, DOI 10.1101/gr.3761405
Moessner R, 2007, AM J HUM GENET, V81, P1289, DOI 10.1086/522S90
Mondal K, 2012, HUM MOL GENET, V21, P4356, DOI 10.1093/hmg/dds267
Moreno-De-Luca D, 2010, AM J HUM GENET, V87, P618, DOI 10.1016/j.ajhg.2010.10.004
Neale BM, 2012, NATURE, V485, P242, DOI 10.1038/nature11011
Noor A, 2010, SCI TRANSL MED, V2, p49ra68
O'Roak BJ, 2012, NATURE, V485, P246, DOI 10.1038/nature10989
Pampanos A, 2009, GENET TEST MOL BIOMA, V13, P611, DOI 10.1089/gtmb.2009.0005
Pinto D, 2010, NATURE, V466, P368, DOI 10.1038/nature09146
Piton A, 2011, Mol Psychiatry, V16, P867, DOI 10.1038/mp.2010.54
Prange O, 2004, P NATL ACAD SCI USA, V101, P13915, DOI 10.1073/pnas.0405939101
Qi HB, 2009, PSYCHIAT GENET, V19, P1, DOI 10.1097/YPG.0b013e3283088e54
Qin J, 2009, BMC MED GENET, V10, DOI 10.1186/1471-2350-10-61
Risch N, 1996, SCIENCE, V273, P1516, DOI 10.1126/science.273.5281.1516
Risch N, 1999, AM J HUM GENET, V65, P493, DOI 10.1086/302497
RITVO ER, 1985, AM J PSYCHIAT, V142, P74
Ronald A, 2011, AM J MED GENET B, V156B, P255, DOI 10.1002/ajmg.b.31159
Rosenberg RE, 2009, ARCH PEDIAT ADOL MED, V163, P907, DOI 10.1001/archpediatrics.2009.98
Sakoda E, 2008, NEUROSCI LETT, V440, P160, DOI 10.1016/j.neulet.2008.04.082
Sanders SJ, 2011, NEURON, V70, P863, DOI 10.1016/j.neuron.2011.05.002
Sanders SJ, 2012, NATURE, V485, P237, DOI 10.1038/nature10945
SCHNEIDER TD, 1990, NUCLEIC ACIDS RES, V18, P6097, DOI 10.1093/nar/18.20.6097
Shendure J, 2008, NAT BIOTECHNOL, V26, P1135, DOI 10.1038/nbt1486
Shetty AC, 2010, BMC BIOINFORMATICS, V11, DOI 10.1186/1471-2105-11-471
Shinawi M, 2009, AM J MED GENET A, V149A, P1138, DOI 10.1002/ajmg.a.32833
State MW, 2011, NAT NEUROSCI, V14, P1499, DOI 10.1038/nn.2924
Suzuki Y, 2003, J NEUROPSYCH CLIN N, V15, P105, DOI 10.1176/appi.neuropsych.15.1.105
Szatmari P, 2007, NAT GENET, V39, P319, DOI 10.1038/ng1985
TAJIMA F, 1989, GENETICS, V123, P585
Talebizadeh Z, 2006, J MED GENET, V43, DOI 10.1136/jmg.2005.036897
Taniai H, 2008, AM J MED GENET B, V147B, P844, DOI 10.1002/ajmg.b.30740
Altshuler D, 2010, NATURE, V467, P1061, DOI 10.1038/nature09534
Altshuler D, 2005, NATURE, V437, P1299, DOI 10.1038/nature04226
Frazer KA, 2007, NATURE, V449, P851, DOI 10.1038/nature06258
Tsai RYL, 1997, J NEUROSCI, V17, P4159
Tsai RYL, 1998, MOL CELL BIOL, V18, P6447
Tsiftsoglou AS, 2006, PHARMACOL THERAPEUT, V111, P327, DOI 10.1016/j.pharmthera.2005.10.017
Varoqueaux F, 2006, NEURON, V51, P741, DOI 10.1016/j.neuron.2006.09.003
Visscher PM, 2012, AM J HUM GENET, V90, P7, DOI 10.1016/j.ajhg.2011.11.029
Wang K, 2009, NATURE, V459, P528, DOI 10.1038/nature07999
WATTERSON GA, 1975, THEOR POPUL BIOL, V7, P256, DOI 10.1016/0040-5809(75)90020-9
Weiss LA, 2008, NEW ENGL J MED, V358, P667, DOI 10.1056/NEJMoa075974
Weiss LA, 2009, NATURE, V461, P802, DOI 10.1038/nature08490
Wisniowiecka-Kowalnik B, 2010, AM J MED GENET B, V153B, P983, DOI 10.1002/ajmg.b.31064
Yan J, 2008, PSYCHIAT GENET, V18, P204, DOI 10.1097/YPG.0b013e3282fb7fe6
Yan J, 2005, MOL PSYCHIATR, V10, P329, DOI 10.1038/sj.mp.4001629
Ylisaukko-oja T, 2005, EUR J HUM GENET, V13, P1285, DOI 10.1038/sj.ejhg.5201474
Zwick ME, 2005, GENOME BIOL, V6
Zwick ME, 2000, ANNU REV GENOM HUM G, V1, P387, DOI 10.1146/annurev.genom.1.1.387
NR 98
TC 2
Z9 2
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 2040-2392
J9 MOL AUTISM
JI Mol. Autism
PD SEP 28
PY 2012
VL 3
AR 8
DI 10.1186/2040-2392-3-8
PG 12
WC Genetics & Heredity; Neurosciences
SC Genetics & Heredity; Neurosciences & Neurology
GA 254ST
UT WOS:000327188000001
PM 23020841
ER
PT J
AU Tanabe, HC
Kosaka, H
Saito, DN
Koike, T
Hayashi, MJ
Izuma, K
Komeda, H
Ishitobi, M
Omori, M
Munesue, T
Okazawa, H
Wada, Y
Sadato, N
AF Tanabe, Hiroki C.
Kosaka, Hirotaka
Saito, Daisuke N.
Koike, Takahiko
Hayashi, Masamichi J.
Izuma, Keise
Komeda, Hidetsugu
Ishitobi, Makoto
Omori, Masao
Munesue, Toshio
Okazawa, Hidehiko
Wada, Yuji
Sadato, Norihiro
TI Hard to"tune in": neural mechanisms of live face-to-face interaction
with high-functioning autistic spectrum disorder
SO FRONTIERS IN HUMAN NEUROSCIENCE
LA English
DT Article
DE functional connectivity; hyperscanning; inter-subject coherence; joint
attention; mutual gaze; autistic spectrum disorder; functional magnetic
resonance imaging
ID HUMAN VISUAL-CORTEX; JOINT ATTENTION; EYE-GAZE; SOCIAL ATTENTION;
COMMUNICATION DISORDERS; DIAGNOSTIC INTERVIEW; BRAIN NETWORKS; CHILDREN;
FMRI; CONNECTIVITY
AB Persons with autism spectrum disorders (ASD) are known to have difficulty in eye contact (EC). This may make it difficult for their partners during face to face communication with them. To elucidate the neural substrates of live inter-subject interaction of ASD patients and normal subjects, we conducted hyper-scanning functional MRI with 21 subjects with autistic spectrum disorder (ASD) paired with typically-developed (normal) subjects, and with 19 pairs of normal subjects as a control. Baseline EC was maintained while subjects performed real-time joint-attention task. The task-related effects were modeled out, and inter-individual correlation analysis was performed on the residual time-course data. ASD-Normal pairs were less accurate at detecting gaze direction than Normal-Normal pairs. Performance was impaired both in ASD subjects and in their normal partners. The left occipital pole (OP) activation by gaze processing was reduced in ASD subjects, suggesting that deterioration of eye-cue detection in ASD is related to impairment of early visual processing of gaze. On the other hand, their normal partners showed greater activity in the bilateral occipital cortex and the right prefrontal area, indicating a compensatory workload. Inter-brain coherence in the right IFG that was observed in the Normal-Normal pairs (Saito et al., 2010) during EC diminished in ASD-Normal pairs. Intra-brain functional connectivity between the right IFG and right superior temporal sulcus (STS) in normal subjects paired with ASD subjects was reduced compared within Normal-Normal pairs. This functional connectivity was positively correlated with performance of the normal partners on the eye-cue detection. Considering the integrative role of the right STS in gaze processing, inter-subject synchronization during EC may be a prerequisite for eye cue detection by the normal partner.
C1 [Tanabe, Hiroki C.; Koike, Takahiko; Hayashi, Masamichi J.; Izuma, Keise; Komeda, Hidetsugu; Sadato, Norihiro] Natl Inst Nat Sci, Natl Inst Physiol Sci, Div Cerebral Integrat, Dept Cerebral Res, Okazaki, Aichi 4448585, Japan.
[Tanabe, Hiroki C.; Hayashi, Masamichi J.; Izuma, Keise; Sadato, Norihiro] Grad Univ Adv Studies, Dept Physiol Sci, Okazaki, Aichi, Japan.
[Tanabe, Hiroki C.] Nagoya Univ, Grad Sch Environm Studies, Nagoya, Aichi 4648601, Japan.
[Kosaka, Hirotaka; Okazawa, Hidehiko; Wada, Yuji] Univ Fukui, Res Ctr Child Mental Dev, Eiheiji, Fukui, Japan.
[Kosaka, Hirotaka; Ishitobi, Makoto; Wada, Yuji] Univ Fukui, Fac Med Sci, Dept Neuropsychiat, Eiheiji, Fukui, Japan.
[Kosaka, Hirotaka; Saito, Daisuke N.; Okazawa, Hidehiko; Sadato, Norihiro] Univ Fukui, Biomed Imaging Res Ctr, Eiheiji, Fukui, Japan.
[Omori, Masao] Fukui Prefectural Univ, Fac Nursing & Social Welfare Sci, Eiheiji, Fukui, Japan.
[Munesue, Toshio] Kanazawa Univ, Res Ctr Child Mental Dev, Kanazawa, Ishikawa, Japan.
RP Sadato, N (reprint author), Natl Inst Nat Sci, Natl Inst Physiol Sci, Div Cerebral Integrat, Dept Cerebral Res, 38 Nishigonaka, Okazaki, Aichi 4448585, Japan.
EM sadato@nips.ac.jp
FU Scientific Research on Innovative Areas from the Ministry of Education,
Culture, Sports, Science, and Technology of Japan (MEXT) [22101007];
Japan Society for the Promotion of Science [23650224, 21791120,
21220005, 21591509]
FX Hiroki C. Tanabe and Hirotaka Kosaka contributed equally to the present
work. This study was partly supported by Scientific Research on
Innovative Areas grant #22101007 (Hiroki C. Tanabe) from the Ministry of
Education, Culture, Sports, Science, and Technology of Japan (MEXT), and
Challenging Exploratory Research grant #23650224 (Hiroki C. Tanabe),
Grants-in-Aid for Young Scientists B #21791120 (Hirotaka Kosaka),
Grant-in-Aid for Scientific Research S #21220005 (Norihiro Sadato),
Grant-in-Aid for Scientific Research C #21591509 (Toshio Munesue) from
the Japan Society for the Promotion of Science. A part of this study
represents the results of the "Development of biomarker candidates for
social behavior" and "Integrated research on neuropsychiatric disorders"
projects carried out under the Strategic Research Program for Brain
Sciences by MEXT.
CR Allison JD, 2000, NEUROLOGY, V54, P135
American Psychiatric Association, 2000, DIAGN STAT MAN MENT
Asperger H, 1944, ARCH PSYCHIAT NERVEN, V117, P76, DOI 10.1007/BF01837709
Baird G, 2006, LANCET, V368, P210, DOI 10.1016/S0140-6736(06)69041-7
Baron-Cohen S, 2001, J AUTISM DEV DISORD, V31, P5, DOI 10.1023/A:1005653411471
Baron-Cohen S., 2008, AUTISM ASPERGER SYND
BARONCOHEN S, 1989, BRIT J DEV PSYCHOL, V7, P113
Baron-Cohen Simon, 1995, MINDBLINDNESS ESSAY
BISWAL B, 1995, MAGNET RESON MED, V34, P537, DOI 10.1002/mrm.1910340409
Bristow D, 2007, SOC COGN AFFECT NEUR, V2, P52, DOI 10.1093/scan/nsl036
BUITELAAR JK, 1995, BEHAVIOUR, V132, P319, DOI 10.1163/156853995X00595
Calder AJ, 2007, CURR BIOL, V17, P20, DOI 10.1016/j.cub.2006.10.052
Calder AJ, 2002, NEUROPSYCHOLOGIA, V40, P1129, DOI 10.1016/S0028-3932(02)00008-8
Charman T, 2003, PHILOS T ROY SOC B, V358, P315, DOI 10.1098/rstb.2002.1199
Cordes D, 2001, AM J NEURORADIOL, V22, P1326
Corkum V, 1998, DEV PSYCHOL, V34, P28, DOI 10.1037/0012-1649.34.1.28
Dalton KM, 2005, NAT NEUROSCI, V8, P519, DOI 10.1038/nn1421
Dawson G, 2004, DEV PSYCHOL, V40, P271, DOI 10.1037/0012-1649.40.2.271
Dupont P, 1997, CEREB CORTEX, V7, P283, DOI 10.1093/cercor/7.3.283
Engell AD, 2010, SOC COGN AFFECT NEUR, V5, P432, DOI 10.1093/scan/nsq008
Fair DA, 2007, NEUROIMAGE, V35, P396, DOI 10.1016/j.neuroimage.2006.11.051
Farroni T, 2002, P NATL ACAD SCI USA, V99, P9602, DOI 10.1073/pnas.152159999
Foerster BU, 2005, MAGNET RESON MED, V54, P1261, DOI 10.1002/mrm.20695
Frischen A, 2007, PSYCHOL BULL, V133, P694, DOI 10.1037/0033-2909.133.4.694
Friston KJ, 1999, NEUROIMAGE, V10, P1, DOI 10.1006/nimg.1999.0439
Friston KJ, 1996, NEUROIMAGE, V4, P223, DOI 10.1006/nimg.1996.0074
Friston K, 2007, STATISTICAL PARAMETRIC MAPPING: THE ANALYSIS OF FUNCTIONAL BRAIN IMAGES, P1
George N, 2001, NEUROIMAGE, V13, P1102, DOI 10.1006/nimg.2001.0769
Greene DJ, 2011, NEUROIMAGE, V56, P354, DOI 10.1016/j.neuroimage.2011.02.031
Greene DJ, 2009, PSYCHOL RES-PSYCH FO, V73, P499, DOI 10.1007/s00426-009-0233-3
Grosbras MN, 2005, HUM BRAIN MAPP, V25, P140, DOI 10.1002/hbm.20145
HEYWOOD CA, 1992, PHILOS T ROY SOC B, V335, P31, DOI 10.1098/rstb.1992.0004
Hobson JA, 2007, DEV PSYCHOPATHOL, V19, P411, DOI 10.1017/S0954579407070204
Hobson R. P., 2002, CRADLE THOUGHT
Hoffman EA, 2000, NAT NEUROSCI, V3, P80, DOI 10.1038/71152
Hooker CI, 2003, COGNITIVE BRAIN RES, V17, P406, DOI 10.1016/S0926-6410(03)00143-5
Kanner L, 1943, NERV CHILD, V2, P217
Kawashima R, 1999, BRAIN, V122, P779, DOI 10.1093/brain/122.4.779
Kosaka H, 2010, NEUROIMAGE, V50, P1357, DOI 10.1016/j.neuroimage.2010.01.085
Leslie KR, 2004, NEUROIMAGE, V21, P601, DOI 10.1016/j.neuroimage.2003.09.038
Lord C, 2000, NEURON, V28, P355, DOI 10.1016/S0896-6273(00)00115-X
Montague PR, 2002, NEUROIMAGE, V16, P1159, DOI 10.1006/nimg.2002.1150
Morita T, 2008, J COGNITIVE NEUROSCI, V20, P342, DOI 10.1162/jocn.2008.20024
Morito Y, 2009, BRAIN RES BULL, V79, P271, DOI 10.1016/j.brainresbull.2009.03.007
Mosconi MW, 2005, NEUROIMAGE, V27, P247, DOI 10.1016/j.neuroimage.2005.03.027
Mundy P, 2010, NEURAL NETWORKS, V23, P985, DOI 10.1016/j.neunet.2010.08.009
Mundy P, 1997, J AUTISM DEV DISORD, V27, P653, DOI 10.1023/A:1025802832021
MUNDY P, 1986, J CHILD PSYCHOL PSYC, V27, P657, DOI 10.1111/j.1469-7610.1986.tb00190.x
Mundy P, 2009, AUTISM RES, V2, P2, DOI 10.1002/aur.61
Nummenmaa L, 2009, TRENDS COGN SCI, V13, P135, DOI 10.1016/j.tics.2008.12.006
Nygren G, 2009, J AUTISM DEV DISORD, V39, P730, DOI 10.1007/s10803-008-0678-z
OLDFIELD RC, 1971, NEUROPSYCHOLOGIA, V9, P97, DOI 10.1016/0028-3932(71)90067-4
ORBAN GA, 1995, P NATL ACAD SCI USA, V92, P993, DOI 10.1073/pnas.92.4.993
OSTERLING J, 1994, J AUTISM DEV DISORD, V24, P247, DOI 10.1007/BF02172225
Pelphrey KA, 2005, BRAIN, V128, P1038, DOI 10.1093/brain/awh404
Redcay E, 2010, NEUROIMAGE, V50, P1639, DOI 10.1016/j.neuroimage.2010.01.052
Redcay E, 2012, FRONT HUM NEUROSCI, V6, DOI 10.3389/fnhum.2012.00169
Redcay E, 2013, HUM BRAIN MAPP, V34, P2511, DOI 10.1002/hbm.22086
Saito Daisuke N, 2010, Front Integr Neurosci, V4, P127, DOI 10.3389/fnint.2010.00127
Schilbach L, 2010, J COGNITIVE NEUROSCI, V22, P2702, DOI 10.1162/jocn.2009.21401
Searle J., 2001, RATIONALITY ACTION
Senju A, 2003, COGNITION, V89, pB43, DOI 10.1016/S0010-0277(03)00081-7
Senju A, 2009, TRENDS COGN SCI, V13, P127, DOI 10.1016/j.tics.2008.11.009
Sigman M, 1999, MONOGR SOC RES CHILD, V64, P1, DOI 10.1111/1540-5834.00002
SIGMAN M, 1986, J CHILD PSYCHOL PSYC, V27, P647, DOI 10.1111/j.1469-7610.1986.tb00189.x
Striano T, 2006, EUR J NEUROSCI, V23, P2819, DOI 10.1111/j.1460-9568.2006.04822.x
Sugiura M, 2006, NEUROIMAGE, V32, P1905, DOI 10.1016/j.neuroimage.2006.05.026
Tipper CM, 2008, J COGNITIVE NEUROSCI, V20, P879, DOI 10.1162/jocn.2008.20510
Trevarthen C., 1979, HUMAN ETHOLOGY CLAIM
Villalobos ME, 2005, NEUROIMAGE, V25, P916, DOI 10.1016/j.neuroimage.2004.12.022
Volkmar F. R., 1990, DEV PSYCHOPATHOL, V2, P61, DOI 10.1017/S0954579400000596
Wechsler D., 1997, WECHSLER ADULT INTEL, VIII
Wicker B, 2003, NEUROPSYCHOLOGIA, V41, P139, DOI 10.1016/S0028-3932(02)00144-6
Wicker B, 1998, NEUROIMAGE, V8, P221, DOI 10.1006/nimg.1998.0357
Williams JHG, 2005, NEUROIMAGE, V25, P133, DOI 10.1016/j.neuroimage.2004.10.047
Wing L, 2002, J CHILD PSYCHOL PSYC, V43, P307, DOI 10.1111/1469-7610.00023
NR 76
TC 6
Z9 8
PU FRONTIERS RESEARCH FOUNDATION
PI LAUSANNE
PA PO BOX 110, LAUSANNE, 1015, SWITZERLAND
SN 1662-5161
J9 FRONT HUM NEUROSCI
JI Front. Hum. Neurosci.
PD SEP 27
PY 2012
VL 6
AR 268
DI 10.3389/fnhum.2012.00268
PG 15
WC Neurosciences; Psychology
SC Neurosciences & Neurology; Psychology
GA 017HL
UT WOS:000309580700001
PM 23060772
ER
PT J
AU Fields, C
AF Fields, Chris
TI The very same thing: Extending the object token concept to incorporate
causal constraints on individual identity
SO ADVANCES IN COGNITIVE PSYCHOLOGY
LA English
DT Review
DE episodic memory; action planning; binding; medial temporal lobe;
posterior parietal cortex; autism spectrum disorders; Alzheimer's
disease
AB The contributions of feature recognition, object categorization, and recollection of episodic memories to the re-identification of a perceived object as the very same thing encountered in a previous perceptual episode are well understood in terms of both cognitive-behavioral phenomenology and neurofunctional implementation. Human beings do not, however, rely solely on features and context to re-identify individuals; in the presence of featural change and similarly-featured distractors, people routinely employ causal constraints to establish object identities. Based on available cognitive and neurofunctional data, the standard object-token based model of individual re-identification is extended to incorporate the construction of unobserved and hence fictive causal histories (FCHs) of observed objects by the pre-motor action planning system. It is suggested that functional deficits in the construction of FCHs are associated with clinical outcomes in both autism spectrum disorders and later-stage stage Alzheimer's disease.
RP Fields, C (reprint author), 814 E Palace Ave 14, Santa Fe, NM 87501 USA.
EM fieldsres@gmail.com
CR American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th
Atran S, 2004, BEHAV BRAIN SCI, V27, P713
Baars B. J., 1997, J CONSCIOUSNESS STUD, V4, P292
Baillargeon R, 2008, PERSPECT PSYCHOL SCI, V3, P2, DOI 10.1111/j.1745-6916.2008.00056.x
Bar M, 2007, TRENDS COGN SCI, V11, P280, DOI 10.1016/j.tics.2007.05.005
Barsalou LW, 2008, ANNU REV PSYCHOL, V59, P617, DOI 10.1146/annurev.psych.59.103006.093639
Bird CM, 2008, NAT REV NEUROSCI, V9, P182, DOI 10.1038/nrn2335
Brady TF, 2008, P NATL ACAD SCI USA, V105, P14325, DOI 10.1073/pnas.0803390105
Bubic A, 2010, FRONT HUM NEUROSCI, V4, DOI 10.3389/fnhum.2010.00025
Buckner RL, 2008, ANN NY ACAD SCI, V1124, P1, DOI 10.1196/annals.1440.011
Bullot NJ, 2009, PHILOS PSYCHOL, V22, P353, DOI 10.1080/09515080902969006
Bullot NJ, 2007, CONSCIOUS COGN, V16, P276, DOI 10.1016/j.concog.2006.09.006
Cabeza R, 2008, NAT REV NEUROSCI, V9, P613, DOI 10.1038/nrn2459
Cattaneo L, 2009, ARCH NEUROL-CHICAGO, V66, P557, DOI 10.1001/archneurol.2009.41
Chun MM, 2011, ANNU REV PSYCHOL, V62, P73, DOI 10.1146/annurev.psych.093008.100427
Corbetta M, 2008, NEURON, V58, P306, DOI 10.1016/j.neuron.2008.04.017
Culham JC, 2006, CURR OPIN NEUROBIOL, V16, P205, DOI 10.1016/j.conb.2006.03.005
Dehaene S, 2001, COGNITION, V79, P1, DOI 10.1016/S0010-0277(00)00123-2
Dehaene S, 2004, COGNITIVE NEUROSCIENCES III, THIRD EDITION, P1145
Diana RA, 2007, TRENDS COGN SCI, V11, P379, DOI 10.1016/j.tics.2007.08.001
Dunbar RIM, 2003, ANNU REV ANTHROPOL, V32, P163, DOI 10.1146/annurev.anthro.32.061002.093158
Eichenbaum H, 2007, ANNU REV NEUROSCI, V30, P123, DOI 10.1146/annurev.neuro.30.051606.094328
Engel A, 2008, SOC NEUROSCI, V3, P368, DOI 10.1080/17470910701612793
Feinberg TE, 2005, PSYCHIAT CLIN N AM, V28, P665, DOI 10.1016/j.psc.2005.05.002
Fields C, 2011, FRONT PSYCHOL, V2, DOI 10.3389/fpsyg.2011.00049
Fields C, 2011, PSYCHOL RES-PSYCH FO, V75, P129, DOI 10.1007/s00426-010-0290-7
Fields C, 2012, COGN PROCESS, V13, P231, DOI 10.1007/s10339-012-0436-1
Flombaum J. I., 2008, ORIGINS OBJECT KNOWL, P135
Frazier BN, 2009, COGNITIVE DEV, V24, P284, DOI 10.1016/j.cogdev.2009.06.003
Gao T, 2010, VIS COGN, V18, P82, DOI 10.1080/13506280802614966
Gazzola V, 2009, CEREB CORTEX, V19, P1239, DOI 10.1093/cercor/bhn181
Gentner D, 2003, BRADFORD BOOKS, P195
Gentner D., 2002, INT ENCY SOCIAL BEHA, P9683
Graham KS, 2010, NEUROPSYCHOLOGIA, V48, P831, DOI 10.1016/j.neuropsychologia.2010.01.001
Gutheil G, 2008, COGNITION, V107, P366, DOI 10.1016/j.cognition.2007.07.014
Heider F, 1944, AM J PSYCHOL, V57, P243, DOI 10.2307/1416950
Henkel L. A., 2008, APPL MEMORY, P213
Heyes C, 2010, NEUROSCI BIOBEHAV R, V34, P575, DOI 10.1016/j.neubiorev.2009.11.007
Holyoak K. J., 2005, CAMBRIDGE HDB THINKI, P117
Hommel B, 2004, TRENDS COGN SCI, V8, P494, DOI 10.1016/j.tics.2004.08.007
Hommel B, 2007, PSYCHOL RES-PSYCH FO, V71, P42, DOI 10.1007/s00426-005-0035-1
Hood BM, 2008, COGNITION, V106, P455, DOI 10.1016/j.cognition.2007.01.012
Hutchinson JB, 2009, LEARN MEMORY, V16, P343, DOI 10.1101/lm.919109
Jicha GA, 2010, J ALZHEIMERS DIS, V19, P253, DOI 10.3233/JAD-2010-1237
Johnson-Frey SH, 2005, CEREB CORTEX, V15, P681, DOI 10.1093/cercor/bhh169
Keizer A. W., 2008, BEHAV BRAIN FUNCT, V4, DOI [10.1186/1744-9081--4-50, DOI 10.1186/1744-9081--4-50]
Kiefer M, 2008, J NEUROSCI, V28, P12224, DOI 10.1523/JNEUROSCI.3579-08.2008
Kiefer M., CORTEX IN PRESS, DOI [10.1016/j.cortex.2011.04.006, DOI 10.1016/J.CORTEX.2011.04.006]
Kiefer M, 2001, MEM COGNITION, V29, P100, DOI 10.3758/BF03195745
Kosslyn S. M., 2006, CASE MENTAL IMAGERY
Lewis JW, 2006, NEUROSCIENTIST, V12, P211, DOI 10.1177/1073858406288327
Mace MJM, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0005927
Mahon BZ, 2009, ANNU REV PSYCHOL, V60, P27, DOI 10.1146/annurev.psych.60.110707.163532
Markman AB, 2001, ANNU REV PSYCHOL, V52, P223, DOI 10.1146/annurev.psych.52.1.223
Martin A, 2007, ANNU REV PSYCHOL, V58, P25, DOI 10.1146/annurev.psych.57.102904.190143
Martinovic J, 2009, PSIHOLOGIJA, V42, P27, DOI 10.2298/PSI0901027M
Minati L, 2009, AM J ALZHEIMERS DIS, V24, P95, DOI 10.1177/1533317508328602
Mitchell K. J., 2000, OXFORD HDB MEMORY, P179
Mori S, 2002, HUM MOVEMENT SCI, V21, P213, DOI 10.1016/S0167-9457(02)00103-3
Moscovitch M, 2008, CAN J EXP PSYCHOL, V62, P62, DOI 10.1037/1196-1961.62.1.62
Moulton ST, 2009, PHILOS T R SOC B, V364, P1273, DOI 10.1098/rstb.2008.0314
Mukamel R, 2010, CURR BIOL, V20, P750, DOI 10.1016/j.cub.2010.02.045
Murray EA, 2007, ANNU REV NEUROSCI, V30, P99, DOI 10.1146/annurev.neuro.29.051605.113046
Nassi JJ, 2009, NAT REV NEUROSCI, V10, P360, DOI 10.1038/nrn2619
Nichols S, 2010, PHILOS PSYCHOL, V23, P293, DOI 10.1080/09515089.2010.490939
Olson IR, 2009, NEUROBIOL LEARN MEM, V91, P155, DOI 10.1016/j.nlm.2008.09.006
Pavlova M, 2006, CEREB CORTEX, V16, P321, DOI 10.1093/cercorbhi108
Pelekis N, 2004, KNOWL ENG REV, V19, P235, DOI 10.1017/S026988890400013X
Petreska B, 2007, PROG BRAIN RES, V164, P61, DOI 10.1016/S0079-6123(07)64004-7
Pezzulo G, 2009, PSYCHOL RES-PSYCH FO, V73, P559, DOI 10.1007/s00426-009-0237-z
Ranganath C, 2004, J NEUROSCI, V24, P3917, DOI 10.1523/JNEUROSCI.5053-03.2004
Ranganath C, 2010, HIPPOCAMPUS, V20, P1263, DOI 10.1002/hipo.20852
Rensink RA, 2002, ANNU REV PSYCHOL, V53, P245, DOI 10.1146/annurev.psych.53.100901.135125
Rhemtulla M, 2009, COGNITION, V113, P167, DOI 10.1016/j.cognition.2009.07.012
Rips LJ, 2006, PSYCHOL REV, V113, P1, DOI 10.1037/0033-295X.113.1.1
Rizzolatti G, 2004, ANNU REV NEUROSCI, V27, P169, DOI 10.1146/annurev.neuro.27.070203.144230
Rosset E, 2008, COGNITION, V108, P771, DOI 10.1016/j.cognition.2008.07.001
Schendan HE, 2009, NEUROIMAGE, V44, P1423, DOI 10.1016/j.neuroimage.2008.09.061
Scholl BJ, 2007, MIND LANG, V22, P563, DOI 10.1111/j.1468-0017.2007.00321.x
Scholl BJ, 2000, TRENDS COGN SCI, V4, P299, DOI 10.1016/S1364-6613(00)01506-0
Schubotz RI, 2004, J NEUROSCI, V24, P5467, DOI 10.1523/JNEUROSCI.1169-04.2004
Schubotz RI, 2007, TRENDS COGN SCI, V11, P211, DOI 10.1016/j.tics.2007.02.006
Sergent C, 2005, NAT NEUROSCI, V8, P1391, DOI 10.1038/nn1549
Simmons DR, 2009, VISION RES, V49, P2705, DOI 10.1016/j.visres.2009.08.005
Simons DJ, 1998, PSYCHON B REV, V5, P644, DOI 10.3758/BF03208840
Simons DJ, 2005, TRENDS COGN SCI, V9, P16, DOI 10.1016/j.tics.2004.11.006
Simons DJ, 2005, CURR DIR PSYCHOL SCI, V14, P44, DOI 10.1111/j.0963-7214.2005.00332.x
Spape MM, 2010, PSYCHOL RES-PSYCH FO, V74, P50, DOI 10.1007/s00426-008-0219-6
Suddendorf T, 2007, BEHAV BRAIN SCI, V30, P299, DOI 10.1017/S0140525X07001975
Thorpe S, 1996, NATURE, V381, P520, DOI 10.1038/381520a0
Tkach D, 2007, J NEUROSCI, V27, P13241, DOI 10.1523/JNEUROSCI.2895-07.2007
Treisman A., 2006, HDB BINDING MEMORY P, P315
Trumpp N. M., CORTEX IN PRESS, DOI [10.1016/j.cortex.2012.02.002, DOI 10.1016/J.CORTEX.2012.02.002]
Uncapher MR, 2009, NEUROBIOL LEARN MEM, V91, P139, DOI 10.1016/j.nlm.2008.10.011
Vogel EK, 2006, J EXP PSYCHOL HUMAN, V32, P1436, DOI 10.1037/0096-1523.32.6.1436
Wagner AD, 2005, TRENDS COGN SCI, V9, P445, DOI 10.1016/j.tics.2005.07.001
Wheeler ME, 2000, P NATL ACAD SCI USA, V97, P11125, DOI 10.1073/pnas.97.20.11125
Xu F, 2007, TRENDS COGN SCI, V11, P400, DOI 10.1016/j.tics.2007.08.002
Yonelinas AP, 2002, J MEM LANG, V46, P441, DOI 10.1006/jmla.2002.2864
Yonelinas AP, 2010, HIPPOCAMPUS, V20, P1178, DOI 10.1002/hipo.20864
Zimmer HD, 2010, NEUROSCI BIOBEHAV R, V34, P1066, DOI 10.1016/j.neubiorev.2010.01.014
Zmigrod S, 2010, ATTEN PERCEPT PSYCHO, V72, P142, DOI 10.3758/APP.72.1.142
NR 102
TC 3
Z9 3
PU VIZJA PRESS & IT
PI WARSZAWA
PA UL DZIELNA 60, WARSZAWA, 01-029, POLAND
SN 1895-1171
J9 ADV COGN PSYCHOL
JI Adv. Cogn. Psychol.
PD SEP 27
PY 2012
VL 8
IS 3
BP 234
EP 247
DI 10.5709/acp-0119-8
PG 14
WC Psychology, Experimental
SC Psychology
GA V37QT
UT WOS:000209291000004
PM 22956989
ER
PT J
AU Young, SZ
Taylor, MM
Wu, SR
Ikeda-Matsuo, Y
Kubera, C
Bordey, A
AF Young, Stephanie Z.
Taylor, M. Morgan
Wu, Sharon
Ikeda-Matsuo, Yuri
Kubera, Cathryn
Bordey, Angelique
TI NKCC1 Knockdown Decreases Neuron Production through GABA(A)-Regulated
Neural Progenitor Proliferation and Delays Dendrite Development
SO JOURNAL OF NEUROSCIENCE
LA English
DT Article
ID POSTNATAL SUBVENTRICULAR ZONE; OLFACTORY-BULB; ADULT NEUROGENESIS;
RECEPTOR ACTIVATION; GABA; CELLS; SCHIZOPHRENIA; CALCIUM; AUTISM; BRAIN
AB Signaling through GABA(A) receptors controls neural progenitor cell (NPC) development in vitro and is altered in schizophrenic and autistic individuals. However, the in vivo function of GABA(A) signaling on neural stem cell proliferation, and ultimately neurogenesis, remains unknown. To examine GABA(A) function in vivo, we electroporated plasmids encoding short-hairpin (sh) RNA against the Na-K-2Cl cotransporter NKCC1 (shNKCC1) in NPCs of the neonatal subventricular zone in mice to reduce GABA(A)-induced depolarization. Reduced GABAA depolarization identified by a loss of GABA(A)-induced calcium responses in most electroporated NPCs led to a 70% decrease in the number of proliferative Ki67(+) NPCs and a 60% reduction in newborn neuron density. Premature loss of GABA(A) depolarization in newborn neurons resulted in truncated dendritic arborization at the time of synaptic integration. However, by 6 weeks the dendritic tree had partially recovered and displayed a small, albeit significant, decrease in dendritic complexity but not total dendritic length. To further examine GABA(A) function on NPCs, we treated animals with a GABA(A) allosteric agonist, pentobarbital. Enhancement of GABA(A) activity in NPCs increased the number of proliferative NPCs by 60%. Combining shNKCC1 and pentobarbital prevented the shNKCC1 and the pentobarbital effects on NPC proliferation, suggesting that these manipulations affected NPCs through GABA(A) receptors. Thus, dysregulation in GABA(A) depolarizing activity delayed dendritic development and reduced NPC proliferation resulting in decreased neuronal density.
C1 [Bordey, Angelique] Yale Univ, Sch Med, Dept Neurosurg, New Haven, CT 06520 USA.
Yale Univ, Sch Med, Dept Cellular & Mol Physiol, New Haven, CT 06520 USA.
RP Bordey, A (reprint author), Yale Univ, Sch Med, Dept Neurosurg, 333 Cedar St,FMB 422, New Haven, CT 06520 USA.
EM angelique.bordey@yale.edu
FU CT Stem Cell initiative; NIH [R01 DC007681]; NRSA [F31 NS063758]; State
of Connecticut under the Connecticut Stem Cell Research Grants Program
FX This work was supported by grants from CT Stem Cell initiative, NIH R01
DC007681 (A.B.) and NRSA F31 NS063758 (S.Z.Y). We thank Ivy Nguyen for
helping with tracing and the lab members for helpful discussion and
comments. The present material is based on work partly supported by the
State of Connecticut under the Connecticut Stem Cell Research Grants
Program. Its contents are solely the responsibility of the authors and
do not necessarily represent the official views of the State of
Connecticut, the Department of Public Health of the State of
Connecticut, or CT Innovations, Inc. The funders had no role in study
design, data collection and analysis, decision to publish, or
preparation of the manuscript.
CR Arion D, 2011, ARCH GEN PSYCHIAT, V68, P21, DOI 10.1001/archgenpsychiatry.2010.114
Bordey A, 2007, BRAIN RES REV, V53, P124, DOI 10.1016/j.brainresrev.2006.07.004
Bordey A, 2006, CELL CYCLE, V5, P722, DOI 10.4161/cc.5.7.2614
Brang D, 2010, MED HYPOTHESES, V74, P919, DOI 10.1016/j.mehy.2008.11.048
Carmosino M, 2008, MOL BIOL CELL, V19, P4341, DOI 10.1091/mbc.E08-05-0478
Cesetti T, 2011, STEM CELLS, V29, P307, DOI 10.1002/stem.573
Chao HT, 2010, NATURE, V468, P263, DOI 10.1038/nature09582
Duveau V, 2011, EUR J NEUROSCI, V34, P362, DOI 10.1111/j.1460-9568.2011.07782.x
Gascon E, 2006, J NEUROSCI, V26, P12956, DOI 10.1523/JNEUROSCI.4508-06.2006
Ge SY, 2006, NATURE, V439, P589, DOI 10.1038/nature04404
Graham V, 2003, NEURON, V39, P749, DOI 10.1016/S0896-6273(03)00497-5
Henschel O, 2008, CNS NEUROL DISORD-DR, V7, P211, DOI 10.2174/187152708784083812
Lacar B, 2011, EUR J NEUROSCI, V34, P1895, DOI 10.1111/j.1460-9568.2011.07901.x
Lacar B., 2010, FRONT NEUROSCI, V4, DOI [10.3389/fnins.2010.00043, DOI 10.3389/FNINS.2010.00043]
Lemasson M, 2005, J NEUROSCI, V25, P6816, DOI 10.1523/JNEUROSCI.1114-05.2005
Liu XX, 2005, NAT NEUROSCI, V8, P1179, DOI 10.1038/nn1522
Liu XX, 2006, GLIA, V54, P394, DOI 10.1002/glia.20392
LoTurco JJ, 1995, NEURON, V15, P1287, DOI 10.1016/0896-6273(95)90008-X
Matsuda T, 2007, P NATL ACAD SCI USA, V104, P1027, DOI 10.1073/pnas.0610155104
Muhle R, 2004, PEDIATRICS, V113, pE472, DOI 10.1542/peds.113.5.e472
Nguyen AD, 2010, HARVARD REV PSYCHIAT, V18, P279, DOI 10.3109/10673229.2010.511060
Nissant A, 2009, NAT NEUROSCI, V12, P728, DOI 10.1038/nn.2298
Owens DF, 2002, NAT REV NEUROSCI, V3, P715, DOI 10.1038/nrn919
Peretto P, 2005, J COMP NEUROL, V487, P407, DOI 10.1002/cne.20576
Petreanu L, 2002, J NEUROSCI, V22, P6106
Platel JC, 2009, GLIA, V57, P66, DOI 10.1002/glia.20735
Platel JC, 2007, EUR J NEUROSCI, V25, P920, DOI 10.1111/j.1460-9568.2007.05367.x
Platel JC, 2010, BRAIN RES REV, V63, P60, DOI 10.1016/j.brainresrev.2010.02.004
Platel JC, 2008, J PHYSIOL-LONDON, V586, P3783, DOI 10.1113/jphysiol.2008.155879
Platel JC, 2010, NEURON, V65, P859, DOI 10.1016/j.neuron.2010.03.009
Potkin SG, 2009, SCHIZOPHRENIA BULL, V35, P96, DOI 10.1093/schbul/sbn155
Rubenstein JLR, 2003, GENES BRAIN BEHAV, V2, P255, DOI 10.1046/j.1601-183X.2003.00037.x
Tobin VA, 2010, NATURE, V464, P413, DOI 10.1038/nature08826
Ventura A, 2004, P NATL ACAD SCI USA, V101, P10380, DOI 10.1073/pnas.0403954101
Wang DD, 2003, J PHYSIOL-LONDON, V550, P785, DOI 10.1113/jphysiol.2003.042572
Wang DD, 2008, J NEUROSCI, V28, P5547, DOI 10.1523/JNEUROSCI.5599-07.2008
Young SZ, 2010, FRONT CELL NEUROSCI, V4, DOI 10.3389/fncel.2010.00008
Young SZ, 2009, PHYSIOLOGY, V24, P171, DOI 10.1152/physiol.00002.2009
NR 38
TC 16
Z9 17
PU SOC NEUROSCIENCE
PI WASHINGTON
PA 11 DUPONT CIRCLE, NW, STE 500, WASHINGTON, DC 20036 USA
SN 0270-6474
J9 J NEUROSCI
JI J. Neurosci.
PD SEP 26
PY 2012
VL 32
IS 39
BP 13630
EP 13638
DI 10.1523/JNEUROSCI.2864-12.2012
PG 9
WC Neurosciences
SC Neurosciences & Neurology
GA 016GR
UT WOS:000309506300032
PM 23015452
ER
PT J
AU Delmonte, S
Balsters, JH
McGrath, J
Fitzgerald, J
Brennan, S
Fagan, AJ
Gallagher, L
AF Delmonte, Sonja
Balsters, Joshua H.
McGrath, Jane
Fitzgerald, Jacqueline
Brennan, Sean
Fagan, Andrew J.
Gallagher, Louise
TI Social and monetary reward processing in autism spectrum disorders
SO MOLECULAR AUTISM
LA English
DT Article
DE Autism; Reward; Social motivation; Striatum; Functional magnetic
resonance imaging; fMRI
ID ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; ALTRUISTIC PUNISHMENT;
DIAGNOSTIC INTERVIEW; DORSAL STRIATUM; YOUNG-CHILDREN; FUNCTIONAL MRI;
BASAL GANGLIA; NEURAL BASIS; ANTICIPATION; FMRI
AB Background: Social motivation theory suggests that deficits in social reward processing underlie social impairments in autism spectrum disorders (ASD). However, the extent to which abnormalities in reward processing generalize to other classes of stimuli remains unresolved. The aim of the current study was to examine if reward processing abnormalities in ASD are specific to social stimuli or can be generalized to other classes of reward. Additionally, we sought to examine the results in the light of behavioral impairments in ASD.
Methods: Participants performed adapted versions of the social and monetary incentive delay tasks. Data from 21 unmedicated right-handed male participants with ASD and 21 age- and IQ-matched controls were analyzed using a factorial design to examine the blood-oxygen-level-dependent (BOLD) response during the anticipation and receipt of both reward types.
Results: Behaviorally, the ASD group showed less of a reduction in reaction time (RT) for rewarded compared to unrewarded trials than the control group. In terms of the fMRI results, there were no significant group differences in reward circuitry during reward anticipation. During the receipt of rewards, there was a significant interaction between group and reward type in the left dorsal striatum (DS). The ASD group showed reduced activity in the DS compared to controls for social rewards but not monetary rewards and decreased activation for social rewards compared to monetary rewards. Controls showed no significant difference between the two reward types. Increased activation in the DS during social reward processing was associated with faster response times for rewarded trials, compared to unrewarded trials, in both groups. This is in line with behavioral results indicating that the ASD group showed less of a reduction in RT for rewarded compared to unrewarded trials. Additionally, de-activation to social rewards was associated with increased repetitive behavior in ASD.
Conclusions: In line with social motivation theory, the ASD group showed reduced activation, compared to controls, during the receipt of social rewards in the DS. Groups did not differ significantly during the processing of monetary rewards. BOLD activation in the DS, during social reward processing, was associated with behavioral impairments in ASD.
C1 [Delmonte, Sonja; McGrath, Jane; Fitzgerald, Jacqueline; Brennan, Sean; Gallagher, Louise] Trinity Coll Dublin, Dept Psychiat, Dublin 2, Ireland.
[Delmonte, Sonja; Balsters, Joshua H.; McGrath, Jane; Fitzgerald, Jacqueline] Trinity Coll Dublin, Trinity Coll Inst Neurosci, Dublin 2, Ireland.
[Fagan, Andrew J.] Trinity Coll Dublin, St James Hosp, CAMI, Dublin 8, Ireland.
RP Delmonte, S (reprint author), Trinity Coll Dublin, Dept Psychiat, Dublin 2, Ireland.
EM sdelmont@tcd.ie
CR Aharon I, 2001, NEURON, V32, P537, DOI 10.1016/S0896-6273(01)00491-3
Ashburner J, 2005, NEUROIMAGE, V26, P839, DOI 10.1016/j.neuroimage.2005.02.018
Balleine BW, 2009, NEUROPSYCHOPHARMACOL, V35, P48, DOI DOI 10.1038/NPP.2009.131
Balleine BW, 2007, J NEUROSCI, V27, P8161, DOI 10.1523/JNEUROSCI.1554-07.2007
Balsters JH, 2011, J NEUROSCI, V31, P2305, DOI 10.1523/JNEUROSCI.4358-10.2011
Balsters JH, 2008, NEUROIMAGE, V43, P388, DOI 10.1016/j.neuroimage.2008.07.010
Berridge KC, 2009, CURR OPIN PHARMACOL, V9, P65, DOI 10.1016/j.coph.2008.12.014
Bjork JM, 2004, J NEUROSCI, V24, P1793, DOI 10.1523/JNEUROSCI.4862-03.2004
Bjork JM, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0011440
Cauda F, 2011, J NEUROL NEUROSUR PS, V82, P1304, DOI 10.1136/jnnp.2010.239111
Chevallier C, 2012, TRENDS COGN SCI, V16, P231, DOI 10.1016/j.tics.2012.02.007
Constantino JN, 2005, BIOL PSYCHIAT, V57, P655, DOI 10.1016/j.biopsych.2004.12.014
Constantino JN, 2003, J AUTISM DEV DISORD, V33, P427, DOI 10.1023/A:1025014929212
Coon H, 2010, MOL AUTISM, V1, DOI 10.1186/2040-2392-1-8
Dapretto M, 2006, NAT NEUROSCI, V9, P28, DOI 10.1038/nn1611
Dawson G, 2005, DEV NEUROPSYCHOL, V27, P403, DOI 10.1207/s15326942dn2703_6
Dawson G, 2012, J NEURODEV DISORD, V4, DOI 10.1186/1866-1955-4-11
Dawson G, 2002, CHILD DEV, V73, P700, DOI 10.1111/1467-8624.00433
Delgado MR, 2003, COGN AFFECT BEHAV NE, V3, P27, DOI 10.3758/CABN.3.1.27
Delgado MR, 2007, ANN NY ACAD SCI, V1104, P70, DOI 10.1196/annals.1390.002
de Quervain DJF, 2004, SCIENCE, V305, P1254, DOI 10.1126/science.1100735
Dichter GS, 2012, J AUTISM DEV DISORD, V42, P147, DOI 10.1007/s10803-011-1221-1
Dichter GS, 2012, SOC COGN AFFECT NEUR, V7, P160, DOI 10.1093/scan/nsq095
Di Martino A, 2011, BIOL PSYCHIAT, V69, P847, DOI 10.1016/j.biopsych.2010.10.029
Eickhoff SB, 2005, NEUROIMAGE, V25, P1325, DOI 10.1016/j.neuroimage.2004.12.034
Estes A, 2011, AUTISM RES, V4, P212, DOI 10.1002/aur.193
FRISTON KJ, 1995, NEUROIMAGE, V2, P166, DOI 10.1006/nimg.1995.1019
FRISTON KJ, 1995, NEUROIMAGE, V2, P157, DOI 10.1006/nimg.1995.1018
Grahn JA, 2008, PROG NEUROBIOL, V86, P141, DOI 10.1016/j.pneurobio.2008.09.004
Haber SN, 2010, NEUROPSYCHOPHARMACOL, V35, P4, DOI 10.1038/npp.2009.129
Hollander E, 2005, BIOL PSYCHIAT, V58, P226, DOI 10.1016/j.biopsych.2005.03.040
Iannetti GD, 2007, MAGN RESON IMAGING, V25, P978, DOI 10.1016/j.mri.2007.03.018
Ino T, 2010, CORTEX, V46, P2, DOI 10.1016/j.cortex.2009.02.022
Izuma K, 2011, P NATL ACAD SCI
Izuma K, 2008, NEURON, V58, P284, DOI 10.1016/j.neuron.2008.03.020
Kim H, 2009, J NEUROSCI, V29, P14701, DOI 10.1523/JNEUROSCI.2728-09.2009
King-Casas B, 2005, SCIENCE, V308, P78, DOI 10.1126/science.1108062
Knutson B, 2001, NEUROREPORT, V12, P3683, DOI 10.1097/00001756-200112040-00016
Knutson B, 2000, NEUROIMAGE, V12, P20, DOI 10.1006/nimg.2000.0593
Knutson B, 2008, BIOL PSYCHIAT, V63, P686, DOI 10.1016/j.biopsych.2007.07.023
Kohls G., 2012, SOC COGN AFFECT NEUR
Kohls G, 2009, DEVELOPMENTAL SCI, V12, P614, DOI 10.1111/j.1467-7687.2009.00816.x
Langen M, 2012, CORTEX, V48, P183, DOI 10.1016/j.cortex.2011.05.018
Langen M, 2009, BIOL PSYCHIAT, V66, P327, DOI 10.1016/j.biopsych.2009.03.017
Lau B, 2008, NEURON, V58, P451, DOI 10.1016/j.neuron.2008.02.021
Lin A, 2012, SOC COGN AFFECT NEUR, V7, P274, DOI 10.1093/scan/nsr006
LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
Lord Catherine, 2011, ARCH GEN PSYCHIAT, V69, p[306, 312]
McAlonan GM, 2009, PSYCHOL MED, V39, P1885, DOI 10.1017/S0033291709005728
Montague PR, 1996, J NEUROSCI, V16, P1936
O'Doherty JP, 2004, CURR OPIN NEUROBIOL, V14
O'Doherty J, 2004, SCIENCE, V304, P452, DOI 10.1126/science.1094285
Perino MT, 2012, EXAMINING NEED MORE
Pierce K, 2001, BIOL PSYCHIAT, V49, P655, DOI 10.1016/S0006-3223(00)01008-8
Rademacher L, 2010, NEUROIMAGE, V49, P3276, DOI 10.1016/j.neuroimage.2009.10.089
Rilling JK, 2002, NEURON, V35, P395, DOI 10.1016/S0896-6273(02)00755-9
Rutter M., 2003, SOCIAL COMMUNICATION
Scheres A, 2007, BIOL PSYCHIAT, V61, P720, DOI 10.1016/j.biopsych.2006.04.042
Schmitz N, 2008, BRIT J PSYCHIAT, V192, P19, DOI 10.1192/bjp.bp.107.036921
Schultz W, 2007, TRENDS NEUROSCI, V30, P203, DOI 10.1016/j.tins.2007.03.007
Scott-Van Zeeland AA, 2010, AUTISM RES, V3, P53, DOI 10.1002/aur.122
Sears LL, 1999, PROG NEURO-PSYCHOPH, V23, P613, DOI 10.1016/S0278-5846(99)00020-2
Shafritz KM, 2008, BIOL PSYCHIAT, V63, P974, DOI 10.1016/j.biopsych.2007.06.028
Sladky R, 2011, NEUROIMAGE, V58, P588, DOI 10.1016/j.neuroimage.2011.06.078
Spreckelmeyer KN, 2009, SOC COGN AFFECT NEUR, V4, P158, DOI 10.1093/scan/nsn051
Stanfield AC, 2008, EUR PSYCHIAT, V23, P289, DOI 10.1016/j.eurpsy.2007.05.006
Strobel A, 2011, NEUROIMAGE, V54, P671, DOI 10.1016/j.neuroimage.2010.07.051
Strohle A, 2008, NEUROIMAGE, V39, P966, DOI 10.1016/j.neuroimage.2007.09.044
Takarae Y, 2007, PSYCHIAT RES-NEUROIM, V156, P117, DOI 10.1016/j.pseychresns.2007.03.008
Tanaka SC, 2006, NEURAL NETWORKS, V19, P1233, DOI 10.1016/j.neunet.2006.05.039
Tottenham N, 2009, PSYCHIAT RES, V168, P242, DOI 10.1016/j.psychres.2008.05.006
Wechsler D., 2003, WECHSLER INTELLIGENC
Wechsler D, 1999, WECHSLER ABBREVIATED
Yu KK, 2011, J PSYCHIATR NEUROSCI, V36
NR 75
TC 24
Z9 24
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 2040-2392
J9 MOL AUTISM
JI Mol. Autism
PD SEP 26
PY 2012
VL 3
AR 7
DI 10.1186/2040-2392-3-7
PG 13
WC Genetics & Heredity; Neurosciences
SC Genetics & Heredity; Neurosciences & Neurology
GA 254SQ
UT WOS:000327187700001
PM 23014171
ER
PT J
AU Gauthier, J
Rouleau, GA
AF Gauthier, Julie
Rouleau, Guy A.
TI De novo mutations in neurological and psychiatric disorders: effects,
diagnosis and prevention
SO GENOME MEDICINE
LA English
DT Review
ID AUTISM SPECTRUM DISORDER; CEREBRAL CAVERNOUS MALFORMATIONS; SCAFFOLDING
PROTEIN SHANK3; RETT-SYNDROME; PATERNAL ORIGIN; MENTAL-RETARDATION;
MECP2 MUTATIONS; INTELLECTUAL DISABILITY; MATERNAL PLASMA; GENE
AB Neurological and psychiatric disorders account for a considerable proportion of the global disease burden. Although there is a high heritability and a significant genetic component in these disorders, the genetic cause of most cases has yet to be identified. Advances in DNA sequencing allowing the analysis of the whole human genome in a single experiment have led to an acceleration of the discovery of the genetic factors associated with human disease. Recent studies using these platforms have highlighted the important role of de novo mutations in neurological and psychiatric disorders. These findings have opened new avenues into the understanding of genetic disease mechanisms. These discoveries, combined with the increasing ease with which we can sequence the human genome, have important implications for diagnosis, prevention and treatment. Here, we present an overview of the recent discovery of de novo mutations using key examples of neurological and psychiatric disorders. We also discuss the impact of technological developments on diagnosis and prevention.
C1 [Gauthier, Julie; Rouleau, Guy A.] Univ Montreal, Ctr Excellence Neurosci, Montreal, PQ H2L 4M1, Canada.
[Gauthier, Julie; Rouleau, Guy A.] Univ Montreal, Ctr Hosp, Ctr Rech, Montreal, PQ H2L 4M1, Canada.
[Rouleau, Guy A.] Univ Montreal, Dept Med, Montreal, PQ H2L 4M1, Canada.
RP Rouleau, GA (reprint author), Univ Montreal, Ctr Excellence Neurosci, Montreal, PQ H2L 4M1, Canada.
EM guy.rouleau@umontreal.ca
CR Aartsma-Rus A, 2003, HUM MOL GENET, V12, P907, DOI 10.1093/hmg/ddg100
American Psychiatric Association, DIAGN STAT MAN MENT
Amir RE, 1999, NAT GENET, V23, P185
Awadalla P, 2010, AM J HUM GENET, V87, P316, DOI 10.1016/j.ajhg.2010.07.019
Bergametti F, 2005, AM J HUM GENET, V76, P42, DOI 10.1086/426952
Boerkoel CF, 2002, ANN NEUROL, V51, P190, DOI 10.1002/ana.10089
Boone PM, 2011, HUM GENET, V130, P103, DOI 10.1007/s00439-011-1001-1
Borg I, 2005, EUR J HUM GENET, V13, P921, DOI 10.1038/sj.ejhg.5201429
Brenner M, 2001, NAT GENET, V27, P117
Cannella M, 2007, J NEUROL NEUROSUR PS, V78, P1411, DOI 10.1136/jnnp.2007.121137
CARLSON KM, 1994, AM J HUM GENET, V55, P1076
CHIU RW, 2011, BRIT MED J, V11, P342
Claes L, 2001, AM J HUM GENET, V68, P1327, DOI 10.1086/320609
Clark MJ, 2011, NAT BIOTECHNOL, V29, P908, DOI 10.1038/nbt.1975
Conrad DF, NATURE, V464, P704
Crow JF, 2006, J RADIAT RES, V47, pB75, DOI 10.1269/jrr.47.B75
Crow JF, 2000, NAT REV GENET, V1, P40, DOI 10.1038/35049558
CURTIS ARJ, 1993, HUM GENET, V90, P551
DeJesus-Hernandez M, 2010, HUM MUTAT, V31, pE1377, DOI 10.1002/humu.21241
Durand CM, 2007, NAT GENET, V39, P25, DOI 10.1038/ng1933
ELIA J, 2012, NAT GENET, V44, P78, DOI DOI 10.1038/ng.1013
Fan HC, 2012, NATURE, V487, P320, DOI 10.1038/nature11251
Freitag CM, 2007, MOL PSYCHIATR, V12, P2, DOI 10.1038/sj.mp.4001896
Gattellari M, 2004, J MED SCREEN, V11, P165, DOI 10.1258/0969141042467386
Gauthier J, 2010, P NATL ACAD SCI USA, V107, P7863, DOI 10.1073/pnas.0906232107
Girard M, 2001, EUR J HUM GENET, V9, P231, DOI 10.1038/sj.ejhg.5200618
Girard SL, 2011, NAT GENET, V43, P860, DOI 10.1038/ng.886
Glaser RL, 2000, AM J HUM GENET, V66, P768, DOI 10.1086/302831
Griswold AJ, 2012, HUM MOL GENET, V21, P3513, DOI 10.1093/hmg/dds164
Hamdan FF, 2009, NEW ENGL J MED, V360, P599, DOI 10.1056/NEJMoa0805392
Hamdan FF, 2011, AM J HUM GENET, V88, P306, DOI 10.1016/j.ajhg.2011.02.001
Hehir-Kwa JY, 2011, J MED GENET, V48, P776, DOI 10.1136/jmedgenet-2011-100147
Helderman-van den Enden ATJM, 2009, CLIN GENET, V75, P465, DOI 10.1111/j.1399-0004.2009.01173.x
Hoischen A, 2010, NAT GENET, V42, P483, DOI 10.1038/ng.581
Iossifov I, 2012, NEURON, V74, P285, DOI 10.1016/j.neuron.2012.04.009
Jacobson J, 1998, BEHAV INTERVENT, V13, P201, DOI DOI 10.1002/(SICI)1099-078X
JADAYEL D, 1990, NATURE, V343, P558, DOI 10.1038/343558a0
Jamain S, 2003, NAT GENET, V34, P27, DOI 10.1038/ng1136
Joutel A, 2000, ANN NEUROL, V47, P388, DOI 10.1002/1531-8249(200003)47:3<388::AID-ANA19>3.0.CO;2-Q
Kaufman L, 2010, J NEURODEV DISORD, V2, P182, DOI 10.1007/s11689-010-9055-2
Kitzman JO, 2012, SCI TRANSL MED, V4, DOI 10.1126/scitranslmed.3004323
KNUDSON AG, 1971, P NATL ACAD SCI USA, V68, P820, DOI 10.1073/pnas.68.4.820
Koide R, 1999, HUM MOL GENET, V8, P2047, DOI 10.1093/hmg/8.11.2047
Kong A, 2012, NATURE, V488, P471, DOI 10.1038/nature11396
Ku CS, 2012, EXPERT REV MOL DIAGN, V12, P211, DOI [10.1586/erm.12.3, 10.1586/ERM.12.3]
Laursen TM, 2010, SCHIZOPHR RES, V121, P234, DOI 10.1016/j.schres.2010.05.018
Lazaro C, 1996, HUM GENET, V98, P696, DOI 10.1007/s004390050287
Lindhurst MJ, 2011, NEW ENGL J MED, V365, P611, DOI 10.1056/NEJMoa1104017
Lo YMD, 1998, NEW ENGL J MED, V339, P1734, DOI 10.1056/NEJM199812103392402
Lo YMD, 1997, LANCET, V350, P485, DOI 10.1016/S0140-6736(97)02174-0
Lucas M, 2001, ANN NEUROL, V49, P529, DOI 10.1002/ana.105
Lynch M, 2010, P NATL ACAD SCI USA, V107, P961, DOI 10.1073/pnas.0912629107
Malhotra D, 2011, NEURON, V72, P951, DOI 10.1016/j.neuron.2011.11.007
McNaughton D, 2012, NEUROBIOL AGING, V33
Moessner R, 2007, AM J HUM GENET, V81, P1289, DOI 10.1086/522S90
Neale BM, 2012, NATURE, V485, P242, DOI 10.1038/nature11011
Ng SB, 2010, NAT GENET, V42, P790, DOI 10.1038/ng.646
Okumura A, 2007, NEUROPEDIATRICS, V38, P253, DOI 10.1055/s-2008-1062703
O'Roak BJ, 2012, NATURE, V485, P246, DOI 10.1038/nature10989
Post B., 2009, Journal of Pediatric Neurology, V7, P171
Pruitt KD, 2009, NUCLEIC ACIDS RES, V37, pD32, DOI 10.1093/nar/gkn721
Riant F, 2010, NEUROLOGY, V75, P967, DOI 10.1212/WNL.0b013e3181f25e8f
Roach JC, 2010, SCIENCE, V328, P636, DOI 10.1126/science.1186802
ROULEAU GA, 1993, NATURE, V363, P515, DOI 10.1038/363515a0
Rujescu D, 2009, HUM MOL GENET, V18, P988, DOI 10.1093/hmg/ddn351
Sanders SJ, 2011, NEURON, V70, P863, DOI 10.1016/j.neuron.2011.05.002
Sanders SJ, 2012, NATURE, V485, P237, DOI 10.1038/nature10945
SARTORIUS N, 1986, PSYCHOL MED, V16, P909
Sato D, 2012, AM J HUM GENET, V90, P879, DOI 10.1016/j.ajhg.2012.03.017
Sayres LC, 2011, OBSTET GYNECOL SURV, V66, P431, DOI 10.1097/OGX.0b013e31822dfbe2
Schanen NC, 1997, AM J HUM GENET, V61, P634, DOI 10.1086/515525
Stefansson H, 2008, NATURE, V455, P232, DOI 10.1038/nature07229
St-Jacques S, 2008, PRENATAL DIAG, V28, P1183, DOI 10.1002/pd.2059
Sullivan PF, 2003, ARCH GEN PSYCHIAT, V60, P1187, DOI 10.1001/archpsyc.60.12.1187
Trappe R, 2001, AM J HUM GENET, V68, P1093, DOI 10.1086/320109
Trofatter J A, 1993, Cell, V75, P826
VALENTIJN LJ, 1995, HUM MUTAT, V5, P76, DOI 10.1002/humu.1380050110
van Os J, 2009, LANCET, V374, P635, DOI 10.1016/S0140-6736(09)60995-8
Veltman JA, 2012, NAT REV GENET, V13, P565, DOI 10.1038/nrg3241
VISKOCHIL D, 1990, CELL, V62, P187, DOI 10.1016/0092-8674(90)90252-A
Vissers LELM, 2010, NAT GENET, V42, P1109, DOI 10.1038/ng.712
Wan MM, 1999, AM J HUM GENET, V65, P1520, DOI 10.1086/302690
Weaving LS, 2004, AM J HUM GENET, V75, P1079, DOI 10.1086/426462
Xu B, 2011, NAT GENET, V43, P864, DOI 10.1038/ng.902
Xu B, 2008, NAT GENET, V40, P880, DOI 10.1038/ng.162
NR 85
TC 0
Z9 0
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1756-994X
J9 GENOME MED
JI Genome Med.
PD SEP 25
PY 2012
VL 4
AR 71
DI 10.1186/gm372
PG 11
WC Genetics & Heredity
SC Genetics & Heredity
GA 084YG
UT WOS:000314576100001
PM 23009675
ER
PT J
AU Noris, B
Nadel, J
Barker, M
Hadjikhani, N
Billard, A
AF Noris, Basilio
Nadel, Jacqueline
Barker, Mandy
Hadjikhani, Nouchine
Billard, Aude
TI Investigating Gaze of Children with ASD in Naturalistic Settings
SO PLOS ONE
LA English
DT Article
ID AUTISM SPECTRUM; IMPAIRED RECOGNITION; SOCIAL CONTINGENCY; BIOLOGICAL
MOTION; INFANTILE-AUTISM; JOINT ATTENTION; YOUNG-CHILDREN; EYE CONTACT;
FACE; PERCEPTION
AB Background: Visual behavior is known to be atypical in Autism Spectrum Disorders (ASD). Monitor-based eye-tracking studies have measured several of these atypicalities in individuals with Autism. While atypical behaviors are known to be accentuated during natural interactions, few studies have been made on gaze behavior in natural interactions. In this study we focused on i) whether the findings done in laboratory settings are also visible in a naturalistic interaction; ii) whether new atypical elements appear when studying visual behavior across the whole field of view.
Methodology/Principal Findings: Ten children with ASD and ten typically developing children participated in a dyadic interaction with an experimenter administering items from the Early Social Communication Scale (ESCS). The children wore a novel head-mounted eye-tracker, measuring gaze direction and presence of faces across the child's field of view. The analysis of gaze episodes to faces revealed that children with ASD looked significantly less and for shorter lapses of time at the experimenter. The analysis of gaze patterns across the child's field of view revealed that children with ASD looked downwards and made more extensive use of their lateral field of view when exploring the environment.
Conclusions/Significance: The data gathered in naturalistic settings confirm findings previously obtained only in monitor-based studies. Moreover, the study allowed to observe a generalized strategy of lateral gaze in children with ASD when they were looking at the objects in their environment.
C1 [Noris, Basilio; Billard, Aude] Ecole Polytech Fed Lausanne, Learning Algorithms & Syst Lab, Lausanne, Switzerland.
[Nadel, Jacqueline] Hop La Pitie Salpetriere, Emot Ctr, Paris, France.
[Barker, Mandy] Univ Lausanne, Univ Hosp Canton Vaud, Dept Child & Adolescent Psychiat, Lausanne, Switzerland.
[Hadjikhani, Nouchine] Ecole Polytech Fed Lausanne, Brain & Mind Inst, Lausanne, Switzerland.
[Hadjikhani, Nouchine] Massachusetts Gen Hosp, Martinos Ctr Biomed Imaging, HST, Boston, MA 02114 USA.
RP Noris, B (reprint author), Ecole Polytech Fed Lausanne, Learning Algorithms & Syst Lab, Lausanne, Switzerland.
EM basilio.noris@epfl.ch
RI Hadjikhani, Nouchine/C-2018-2008
OI Hadjikhani, Nouchine/0000-0003-4075-3106
FU National Centre for Competence in Research of the Swiss National Science
Foundation
FX This work was funded by the IM2 program of the National Centre for
Competence in Research of the Swiss National Science Foundation. The
funders had no role in study design, data collection and analysis,
decision to publish, or preparation of the manuscript.
CR (APA) APA, 2000, DIAGN STAT MAN MENT
Ashwin C, 2006, SOC NEUROSCI, V1, P349, DOI 10.1080/17470910601040772
BARONCOHEN S, 1995, BRIT J DEV PSYCHOL, V13, P379
Billard A., 2006, RESNA ASSISTIVE TECH, V19, P37
Bird G, 2006, NEUROIMAGE, V31, P1614, DOI 10.1016/j.neuroimage.2006.02.037
Blake R, 2003, PSYCHOL SCI, V14, P151, DOI 10.1111/1467-9280.01434
Bogdashina O, 2003, SENSORY PERCEPTUAL I
Butterworth G., 1999, IMITATION INFANCY
Chawarska K, 2009, J AUTISM DEV DISORD, V39, P1663, DOI 10.1007/s10803-009-0803-7
Dakin S, 2005, NEURON, V48, P497, DOI 10.1016/j.neuron.2005.10.018
Dalton KM, 2005, NAT NEUROSCI, V8, P519, DOI 10.1038/nn1421
Elison JT, 2008, IMFAR LOND
Fletcher-Watson S, 2008, J AUTISM DEV DISORD, V38, P1785, DOI 10.1007/s10803-008-0548-8
Gaily E, 2009, EPILEPSIA, V50, P206, DOI 10.1111/j.1528-1167.2008.01961.x
Golarai G, 2006, CLIN NEUROSCI RES, V6, P145, DOI 10.1016/j.cnr.2006.08.001
Grandin T, 1995, THINKING PICTURES EX
Grynszpan O, 2009, P IEEE C VI IN PRESS
HENDRICKSON A, 1992, BEHAV BRAIN RES, V49, P21, DOI 10.1016/S0166-4328(05)80191-3
HUTT C, 1966, BEHAV SCI, V11, P346, DOI 10.1002/bs.3830110504
Jemel B, 2006, J AUTISM DEV DISORD, V36, P91, DOI 10.1007/s10803-005-0050-5
Jones F, 2008, ARCH GEN PSYCHIAT, V65
Joseph RM, 2003, J CHILD PSYCHOL PSYC, V44, P529, DOI 10.1111/1469-7610.00142
Kennedy DP, 2009, NAT NEUROSCI, V12, P1226, DOI 10.1038/nn.2381
Klin A, 2008, DEVELOPMENTAL SCI, V11, P40, DOI 10.1111/j.1467-7687.2007.00608.x
Klin A, 2002, AM J PSYCHIAT, V159, P895, DOI 10.1176/appi.ajp.159.6.895
Landry R, 2004, J CHILD PSYCHOL PSYC, V45, P1115, DOI 10.1111/j.1469-7610.2004.00304.x
Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
Merin N, 2007, J AUTISM DEV DISORD, V37, P108, DOI 10.1007/s10803-006-0342-4
Mottron L, 2006, J AUTISM DEV DISORD, V36, P27, DOI 10.1007/s10803-005-0040-7
Mottron L, 2007, DEV PSYCHOPATHOL, V19, P23, DOI 10.1017/S0954579407070022
Mundy P, 1997, J AUTISM DEV DISORD, V27, P653, DOI 10.1023/A:1025802832021
Mundy P., 2003, MANUAL ABRIDGED EARL
Nadel J, 1999, DEVELOPMENTAL SCI, V2, P164, DOI 10.1111/1467-7687.00065
Noris B, 2010, J COMPUTER VISION IM
Noris B., 2007, COMPUTER RECOGNITION, V2, P663, DOI [10.1007/978-3-540-75175-5_83, DOI 10.1007/978-3-540-75175-5_]
Pedersen J, 1997, EUR CHILD ADOLES PSY, V6, P96
Pelphrey KA, 2002, J AUTISM DEV DISORD, V32, P249, DOI 10.1023/A:1016374617369
Riby DM, 2008, J AUTISM DEV DISORD, V39, P421
RICHER JM, 1976, ACTA PSYCHIAT SCAND, V53, P193, DOI 10.1111/j.1600-0447.1976.tb00074.x
RITVO ER, 1986, J AM ACAD CHILD PSY, V25, P137, DOI 10.1016/S0002-7138(09)60611-7
Robins B., 2005, Universal Access in the Information Society, V4, DOI 10.1007/s10209-005-0116-3
Roos EM, 2008, AUTISM, V12, P275, DOI 10.1177/1362361307089521
Scassellati B, 2007, SPR TRA ADV ROBOT, V28, P552
Seibert J. M., 1982, INFANT MENT HEALTH J, V3, P244, DOI DOI 10.1002/1097-0355(198224)3:4<244::AID-IMHJ2280030406>3.0.CO;2-R
Senju A, 2009, NEUROSCI BIOBEHAV R, V33, P1204, DOI 10.1016/j.neubiorev.2009.06.001
Senju A, 2009, TRENDS COGN SCI, V13, P127, DOI 10.1016/j.tics.2008.11.009
Shic F, 2007, DEV LEARN 2007 ICDL, P70
Shic F., 2008, P EYE TRACK RES APPL
Sigman M, 2004, MENT RETARD DEV D R, V10, P221, DOI 10.1002/mrdd.20046
Simmons DR, 2009, VISION RES, V49, P2705, DOI 10.1016/j.visres.2009.08.005
Soussignan R, 2006, INFANCY, V10, P123, DOI 10.1207/s15327078in1002_2
Sparrow S, 1984, VINELAND ADAPTIVE BE
Speer LL, 2007, AUTISM, V11, P265, DOI 10.1177/1362361307076925
Spezio ML, 2007, J NEUROSCI, V27, P3994, DOI 10.1523/JNEUROSCI.3789-06.2007
Spezio ML, 2007, J AUTISM DEV DISORD, V37, P929, DOI 10.1007/s10803-006-0232-9
Swettenham J, 1998, J CHILD PSYCHOL PSYC, V39, P747, DOI 10.1017/S0021963098002595
Trepagnier C, 2002, CYBERPSYCHOL BEHAV, V5, P213, DOI 10.1089/109493102760147204
Yoshida H, 2008, INFANCY, V13, P229, DOI 10.1080/15250000802004437
Young GS, 2009, DEV SCI
Zwaigenbaum L, 2005, INT J DEV NEUROSCI, V23, P143, DOI 10.1016/j.ijdevneu.2004.05.001
NR 60
TC 10
Z9 10
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD SEP 24
PY 2012
VL 7
IS 9
AR e44144
DI 10.1371/journal.pone.0044144
PG 11
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 016YB
UT WOS:000309554700007
PM 23028494
ER
PT J
AU Knoth, IS
Lippe, S
AF Knoth, Inga S.
Lippe, Sarah
TI Event-related potential alterations infragile X syndrome
SO FRONTIERS IN HUMAN NEUROSCIENCE
LA English
DT Review
DE fragile X syndrome; event; related potential; cognition; intellectual
disability; autism spectrum disorders
ID AUDITORY-EVOKED POTENTIALS; MISMATCH NEGATIVITY MMN; FRAGILE-X;
MENTAL-RETARDATION; SENSORY-MEMORY; N1 WAVE; INTELLECTUAL DISABILITY;
SPATIAL ATTENTION; BRAIN-DEVELOPMENT; TARGET DETECTION
AB Fragile X Syndrome (FXS) is the most common form of X-linked intellectual disability (ID), associated with a wide range of cognitive and behavioral impairments. FXS is caused by a trinucleotide repeat expansion in the FMR1 gene located on the X-chromosome. FMR1 is expected to prevent the expression of the "fragile X mental retardation protein (FMRP)", which results in altered structural and functional development of the synapse, including a loss of synaptic plasticity. This review aims to unveil the contribution of electrophysiological signal studies for the understanding of the information processing impairments in FXS patients. We discuss relevant event-related potential (ERP) studies conducted with full mutation FXS patients and clinical populations sharing symptoms with FXS in a developmental perspective. Specific deviances found in FXS ERP profiles are described. Alterations are reported in N1, P2, Mismatch Negativity (MMN), N2, and P3 components in FXS compared to healthy controls. Particularly, deviances in N1 and P2 amplitude seem to be specific to FXS. The presented results suggest a cascade of impaired information processes that are in line with symptoms and anatomical findings in FXS.
C1 [Knoth, Inga S.; Lippe, Sarah] Univ Montreal, Dept Psychol, CHU Ste Justine, Ctr Rech, Montreal, PQ H3C 3J7, Canada.
[Knoth, Inga S.; Lippe, Sarah] Univ Montreal, Ctr Rech Neuropsychol & Cognit, Montreal, PQ H3C 3J7, Canada.
RP Knoth, IS (reprint author), Univ Montreal, Dept Psychol, CHU Ste Justine, Ctr Rech, CP 6128,Succursale Ctr Ville Montreal, Montreal, PQ H3C 3J7, Canada.
EM inga.knoth@umontreal.ca
CR Albrecht R, 2000, CLIN NEUROPHYSIOL, V111, P2268, DOI 10.1016/S1388-2457(00)00464-8
ALHO K, 1995, EAR HEARING, V16, P38, DOI 10.1097/00003446-199502000-00004
Anderer P, 1996, ELECTROEN CLIN NEURO, V99, P458, DOI 10.1016/S0013-4694(96)96518-9
Antal A, 2000, COGNITIVE BRAIN RES, V9, P117, DOI 10.1016/S0926-6410(99)00053-1
Bassell GJ, 2008, NEURON, V60, P201, DOI 10.1016/j.neuron.2008.10.004
BAUMGARDNER TL, 1995, PEDIATRICS, V95, P744
Bear MF, 2004, TRENDS NEUROSCI, V27, P370, DOI 10.1016/j.tins.2004.04.009
Bennetto L, 2001, NEUROPSYCHOLOGY, V15, P290, DOI 10.1037/0894-4105.15.2.290
Berry-Kravis E, 2009, J MED GENET, V46, P266, DOI 10.1136/jmg.2008.063701
Blackwood D. H., 1985, J GERONTOL B-PSYCHOL, V326, P34
Bomba MD, 2004, INT J PSYCHOPHYSIOL, V53, P161, DOI 10.1016/j.ijpsycho.2004.04.001
Brecelj J, 2002, CLIN NEUROPHYSIOL, V113, P1764, DOI 10.1016/S1388-2457(02)00254-7
BREGMAN JD, 1988, J AUTISM DEV DISORD, V18, P343, DOI 10.1007/BF02212191
Bruneau N, 1997, PSYCHOPHYSIOLOGY, V34, P32, DOI 10.1111/j.1469-8986.1997.tb02413.x
Bruneau N, 1999, CLIN NEUROPHYSIOL, V110, P1927, DOI 10.1016/S1388-2457(99)00149-2
Budimirovic DB, 2006, AM J MED GENET A, V140A, P1814, DOI 10.1002/ajmg.a.31405
Castren M, 2003, BRAIN TOPOGR, V15, P165, DOI 10.1023/A:1022606200636
Cesar CPHAR, 2010, BRAZ J OTORHINOLAR, V76, P206, DOI 10.1590/S1808-86942010000200010
Cheour M, 2000, CLIN NEUROPHYSIOL, V111, P4, DOI 10.1016/S1388-2457(99)00191-1
CheourLuhtanen M, 1996, PSYCHOPHYSIOLOGY, V33, P478, DOI 10.1111/j.1469-8986.1996.tb01074.x
Comery TA, 1997, P NATL ACAD SCI USA, V94, P5401, DOI 10.1073/pnas.94.10.5401
Cornish K, 2005, BRAIN COGNITION, V57, P53, DOI 10.1016/j.bandc.2004.08.020
Cornish KM, 2008, CORTEX, V44, P628, DOI 10.1016/j.cortex.2006.11.002
COURCHESNE E, 1985, J AUTISM DEV DISORD, V15, P55, DOI 10.1007/BF01837899
Courchesne E, 1990, EVENT RELATED BRAIN, P210
Crowley KE, 2004, CLIN NEUROPHYSIOL, V115, P732, DOI 10.1016/j.clinph.2003.11.021
CSEPE V, 1995, EAR HEARING, V16, P91
Daily DK, 2000, AM FAM PHYSICIAN, V61, P1059
Di Russo F, 2002, HUM BRAIN MAPP, V15, P95, DOI 10.1002/hbm.10010
DONCHIN E, 1981, PSYCHOPHYSIOLOGY, V18, P493, DOI 10.1111/j.1469-8986.1981.tb01815.x
Escera C, 2007, J PSYCHOPHYSIOL, V21, P251, DOI 10.1027/0269-8803.21.34.251
Farzin F, 2010, FRONT HUM NEUROSCI, V4, DOI 10.3389/neuro.09.012.2010
Ferri R, 2003, CLIN NEUROPHYSIOL, V114, P1671, DOI 10.1016/S1388-2457(03)00153-6
Freunberger R, 2007, NEUROSCI LETT, V426, P181, DOI 10.1016/j.neulet.2007.08.062
FUCHIGAMI T, 1993, DEV MED CHILD NEUROL, V35, P230
Garner C, 1999, J INTELL DISABIL RES, V43, P466, DOI 10.1046/j.1365-2788.1999.00207.x
Godey B, 2001, CLIN NEUROPHYSIOL, V112, P1850, DOI 10.1016/S1388-2457(01)00636-8
Gomes H, 2001, DEV BRAIN RES, V129, P147, DOI 10.1016/S0165-3806(01)00196-1
Gomot M, 2002, PSYCHOPHYSIOLOGY, V39, P577, DOI 10.1017/S0048577202394058
Gomot M, 2000, NEUROREPORT, V11, P3109, DOI 10.1097/00001756-200009280-00014
GOODIN DS, 1978, ELECTROEN CLIN NEURO, V44, P447, DOI 10.1016/0013-4694(78)90029-9
Goodrich-Hunsaker Naomi J, 2011, Front Hum Neurosci, V5, P63, DOI 10.3389/fnhum.2011.00063
Gothelf D, 2008, ANN NEUROL, V63, P40, DOI 10.1002/ana.21243
Guiraud JA, 2011, NEUROREPORT, V22, P845, DOI 10.1097/WNR.0b013e32834c0bec
Henderson RM, 2000, ACTA PAEDIATR, V89, P52, DOI 10.1080/080352500750029068
Hillyard Steven A., 1995, P665
Hoeft F, 2010, P NATL ACAD SCI USA, V107, P9335, DOI 10.1073/pnas.1002762107
Hoeft F, 2007, HUM BRAIN MAPP, V28, P543, DOI 10.1002/hbm.20406
Holopainen IE, 1998, J CHILD NEUROL, V13, P178
Ikeda K, 2000, PERCEPT MOTOR SKILL, V91, P1145, DOI 10.2466/PMS.91.7.1145-1150
Ikeda K, 2004, NEUROREPORT, V15, P1053, DOI 10.1097/01.wnr.0000125801.83779.29
Ikeda K, 2009, INT J NEUROSCI, V119, P778, DOI 10.1080/03008200802323842
ISREAL JB, 1980, PSYCHOPHYSIOLOGY, V17, P259, DOI 10.1111/j.1469-8986.1980.tb00146.x
Jaaskelainen IP, 2004, P NATL ACAD SCI USA, V101, P6809, DOI 10.1073/pnas.0303760101
JOHANNES S, 1995, COGNITIVE BRAIN RES, V2, P189, DOI 10.1016/0926-6410(95)90008-X
JOHNSON R, 1989, PSYCHOPHYSIOLOGY, V26, P651, DOI 10.1111/j.1469-8986.1989.tb03167.x
Johnstone SJ, 1996, INT J PSYCHOPHYSIOL, V24, P223, DOI 10.1016/S0167-8760(96)00065-7
Karhu J, 1997, NEUROREPORT, V8, P1327, DOI 10.1097/00001756-199704140-00002
KARRER R, 1995, AM J MENT RETARD, V100, P146
Kiehl KA, 2001, PSYCHOPHYSIOLOGY, V38, P133, DOI 10.1017/S0048577201981867
Korzyukov O, 1999, NEUROSCI LETT, V276, P169, DOI 10.1016/S0304-3940(99)00807-1
Krueger DD, 2011, ANNU REV MED, V62, P411, DOI 10.1146/annurev-med-061109-134644
LADISH C, 1989, J EXP CHILD PSYCHOL, V48, P212, DOI 10.1016/0022-0965(89)90003-9
LINCOLN AJ, 1995, J AUTISM DEV DISORD, V25, P521, DOI 10.1007/BF02178298
Lippe S, 2007, CEREB CORTEX, V17, P100, DOI 10.1093/cercor/bhj130
Lippe S, 2009, NEUROSCIENCE, V164, P1108, DOI 10.1016/j.neuroscience.2009.07.066
Loesch DZ, 2003, NEUROPSYCHOLOGY, V17, P646, DOI 10.1037/0894-4105.17.4.646
Luck S. J., 2005, INTRO EVENT RELATED
Luck SJ, 1998, PSYCHOL SCI, V9, P223, DOI 10.1111/1467-9280.00043
LUCK SJ, 1994, PSYCHOPHYSIOLOGY, V31, P291, DOI 10.1111/j.1469-8986.1994.tb02218.x
Luck SJ, 2000, TRENDS COGN SCI, V4, P432, DOI 10.1016/S1364-6613(00)01545-X
Meguid NA, 2012, BRAIN COGNITION, V78, P74, DOI 10.1016/j.bandc.2011.09.005
Morokuma S, 2004, BEHAV BRAIN RES, V153, P459, DOI 10.1016/j.bbr.2004.01.002
Moyle JJ, 2006, CLIN NEUROPHYSIOL, V117, P2154, DOI 10.1016/j.clinph.2006.05.027
Mueller V, 2008, BMC NEUROSCI, V9, DOI 10.1186/1471-2202-9-18
NAATANEN R, 1987, PSYCHOPHYSIOLOGY, V24, P375, DOI 10.1111/j.1469-8986.1987.tb00311.x
Näätänen R, 1986, Electroencephalogr Clin Neurophysiol Suppl, V38, P169
Nakagawa K., 2002, INT C SER, V1232, P363, DOI 10.1016/S0531-5131(01)00820-2
Oades RD, 1997, PSYCHOPHYSIOLOGY, V34, P677, DOI 10.1111/j.1469-8986.1997.tb02143.x
OPITZ JM, 1984, AM J MED GENET, V17, P101, DOI 10.1002/ajmg.1320170105
PAETAU R, 1995, J CLIN NEUROPHYSIOL, V12, P177, DOI 10.1097/00004691-199503000-00008
Patel Salil H, 2005, Int J Med Sci, V2, P147
PEARCE JW, 1989, J CHILD NEUROL, V4, P100
Pfeiffer BE, 2009, NEUROSCIENTIST, V15, P549, DOI 10.1177/1073858409333075
Pfeiffer BE, 2007, J NEUROSCI, V27, P3120, DOI 10.1523/JNEUROSCI.0054-07.2007
Pfueller U, 2011, INT J PSYCHOPHYSIOL, V79, P184, DOI 10.1016/j.ijpsycho.2010.10.005
PICTON TW, 1992, J CLIN NEUROPHYSIOL, V9, P456, DOI 10.1097/00004691-199210000-00002
PICTON TW, 1984, PSYCHOPHYSIOLOGY, V21, P312, DOI 10.1111/j.1469-8986.1984.tb02941.x
Polich J, 2007, CLIN NEUROPHYSIOL, V118, P2128, DOI 10.1016/j.clinph.2007.04.019
Ponton CW, 2000, CLIN NEUROPHYSIOL, V111, P220, DOI 10.1016/S1388-2457(99)00236-9
PRIMROSE DA, 1986, BRIT J PSYCHIAT, V148, P655, DOI 10.1192/bjp.148.6.655
PSATTA DM, 1981, BIOL PSYCHIAT, V16, P729
REISS AL, 1994, NEUROLOGY, V44, P1317
REITE M, 1989, ARCH GEN PSYCHIAT, V46, P565
Reite M, 1997, ARCH GEN PSYCHIAT, V54, P433
Ceponiene R, 2002, CLIN NEUROPHYSIOL, V113, P870, DOI 10.1016/S1388-2457(02)00078-0
Rogers SJ, 2001, J DEV BEHAV PEDIATR, V22, P409
Rojas DC, 2001, NEUROREPORT, V12, P2573, DOI 10.1097/00001756-200108080-00056
Ropers HH, 2010, ANNU REV GENOM HUM G, V11, P161, DOI 10.1146/annurev-genom-082509-141640
Ropers HH, 2005, NAT REV GENET, V6, P46, DOI 10.1038/nrg1501
Rowe DC, 1998, INTELLIGENCE, V26, P405, DOI 10.1016/S0160-2896(99)00008-2
Ruhnau P, 2011, NEUROIMAGE, V58, P630, DOI 10.1016/j.neuroimage.2011.06.050
SCHAFER EWP, 1982, AM J MENT DEF, V87, P332
Schneider A, 2009, DEV DISABIL RES REV, V15, P333, DOI 10.1002/ddrr.80
Seidl R, 1997, COGNITIVE BRAIN RES, V5, P301, DOI 10.1016/S0926-6410(97)00008-6
Shafer VL, 2000, EAR HEARING, V21, P242, DOI 10.1097/00003446-200006000-00008
SIMSON R, 1977, ELECTROEN CLIN NEURO, V42, P528, DOI 10.1016/0013-4694(77)90216-4
SMITH ME, 1986, ELECTROEN CLIN NEURO, V63, P145, DOI 10.1016/0013-4694(86)90008-8
SOKOLOV EN, 1963, ANNU REV PHYSIOL, V25, P545, DOI 10.1146/annurev.ph.25.030163.002553
SQUIRES NK, 1975, ELECTROEN CLIN NEURO, V38, P387, DOI 10.1016/0013-4694(75)90263-1
STCLAIR DM, 1987, BIOL PSYCHIAT, V22, P303, DOI 10.1016/0006-3223(87)90148-X
Sudhalter V, 2001, AM J MENT RETARD, V106, P389, DOI 10.1352/0895-8017(2001)106<0389:CCOCWF>2.0.CO;2
Sullivan K, 2007, AM J MED GENET B, V144B, P517, DOI 10.1002/ajmg.b.30504
Sussman ES, 2007, J PSYCHOPHYSIOL, V21, P164, DOI 10.1027/0269-8803.21.34.164
TONNQUISTUHLEN I, 1995, ELECTROEN CLIN NEURO, V95, P34, DOI 10.1016/0013-4694(95)00044-Y
Turk J, 1998, J INTELL DISABIL RES, V42, P490, DOI 10.1046/j.1365-2788.1998.4260490.x
Van der Molen MJW, 2012, CLIN NEUROPHYSIOL, V123, P1309, DOI 10.1016/j.clinph.2011.11.039
Van der Molen MJW, 2012, CLIN NEUROPHYSIOL, V123, P720, DOI 10.1016/j.clinph.2011.08.023
Van der Molen MJW, 2010, RES DEV DISABIL, V31, P426, DOI 10.1016/j.ridd.2009.10.013
VERBATEN MN, 1991, J AUTISM DEV DISORD, V21, P449, DOI 10.1007/BF02206870
VERLEGER R, 1994, PSYCHOPHYSIOLOGY, V31, P359, DOI 10.1111/j.1469-8986.1994.tb02444.x
Vogel EK, 2000, PSYCHOPHYSIOLOGY, V37, P190, DOI 10.1017/S0048577200981265
Weiler IJ, 1999, AM J MED GENET, V83, P248, DOI 10.1002/(SICI)1096-8628(19990402)83:4<248::AID-AJMG3>3.0.CO;2-1
Wetzel N, 2007, BRAIN RES, V1155, P134, DOI 10.1016/j.brainres.2007.04.022
Wijers AA, 1997, PSYCHOPHYSIOLOGY, V34, P553, DOI 10.1111/j.1469-8986.1997.tb01742.x
World Health Organization, 2004, ICD 10 INT STAT CLAS
Yamamori H, 2002, PEDIATR INT, V44, P420, DOI 10.1046/j.1442-200X.2002.01578.x
NR 127
TC 5
Z9 5
PU FRONTIERS RESEARCH FOUNDATION
PI LAUSANNE
PA PO BOX 110, LAUSANNE, 1015, SWITZERLAND
SN 1662-5161
J9 FRONT HUM NEUROSCI
JI Front. Hum. Neurosci.
PD SEP 24
PY 2012
VL 6
AR 264
DI 10.3389/fnhum.2012.00264
PG 17
WC Neurosciences; Psychology
SC Neurosciences & Neurology; Psychology
GA 010PZ
UT WOS:000309107900001
PM 23015788
ER
PT J
AU Cao, FJ
Yin, AL
Wen, G
Sheikh, AM
Tauqeer, Z
Malik, M
Nagori, A
Schirripa, M
Schirripa, F
Merz, G
Brown, WT
Li, XH
AF Cao, Fujiang
Yin, Ailan
Wen, Guang
Sheikh, Ashfaq M.
Tauqeer, Zujaja
Malik, Mazhar
Nagori, Amenah
Schirripa, Michael
Schirripa, Frank
Merz, George
Brown, W. Ted
Li, Xiaohong
TI Alteration of astrocytes and Wnt/beta-catenin signaling in the frontal
cortex of autistic subjects
SO JOURNAL OF NEUROINFLAMMATION
LA English
DT Article
DE Autism; Astrocytes; Morphology; Wnt/beta-catenin pathway; Neural
plasticity
ID FIBRILLARY ACIDIC PROTEIN; CENTRAL-NERVOUS-SYSTEM; NEURONAL
DIFFERENTIATION; INFLAMMATORY RESPONSE; CEREBROSPINAL-FLUID; INBRED
STRAINS; MICE; BRAIN; CHILDREN; CNS
AB Background: Autism is a neurodevelopmental disorder characterized by impairments in social interaction, verbal communication and repetitive behaviors. To date the etiology of this disorder is poorly understood. Studies suggest that astrocytes play critical roles in neural plasticity by detecting neuronal activity and modulating neuronal networks. Recently, a number of studies suggested that an abnormal function of glia/astrocytes may be involved in the development of autism. However, there is yet no direct evidence showing how astrocytes develop in the brain of autistic individuals.
Methods: Study subjects include brain tissue from autistic subjects, BTBR T + tfJ (BTBR) and Neuroligin (NL)-3 knock-down mice. Western blot analysis, Immunohistochemistry and confocal microscopy studies have be used to examine the density and morphology of astrocytes, as well as Wnt and beta-catenin protein expression.
Results: In this study, we demonstrate that the astrocytes in autisitcsubjects exhibit significantly reduced branching processes, total branching length and cell body sizes. We also detected an astrocytosis in the frontal cortex of autistic subjects. In addition, we found that the astrocytes in the brain of an NL3 knockdown mouse exhibited similar alterations to what we found in the autistic brain. Furthermore, we detected that both Wnt and beta-catenin proteins are decreased in the frontal cortex of autistic subjects. Wnt/beta-catenin pathway has been suggested to be involved in the regulation of astrocyte development.
Conclusions: Our findings imply that defects in astrocytes could impair neuronal plasticity and partially contribute to the development of autistic-like behaviors in both humans and mice. The alteration of Wnt/beta-catenin pathway in the brain of autistic subjects may contribute to the changes of astrocytes.
C1 [Cao, Fujiang; Yin, Ailan; Sheikh, Ashfaq M.; Tauqeer, Zujaja; Malik, Mazhar; Nagori, Amenah; Schirripa, Michael; Schirripa, Frank; Li, Xiaohong] New York State Inst Basic Res Dev Disabil, Dept Neurochem, Staten Isl, NY 10314 USA.
[Wen, Guang] New York State Inst Basic Res Dev Disabil, Dept Dev Neurobiol, New York, NY USA.
[Merz, George; Brown, W. Ted] New York State Inst Basic Res Dev Disabil, New York, NY 10314 USA.
[Cao, Fujiang] Tianjin Med Univ, Gen Hosp, Dept Orthopaed, Tianjin, Peoples R China.
RP Li, XH (reprint author), New York State Inst Basic Res Dev Disabil, Dept Neurochem, 1050 Forest Hill Rd, Staten Isl, NY 10314 USA.
EM xiaohongli99@gmail.com
FU NYS Office for People with Developmental Disabilities; Rural India
Charitable Trust; Richmond County Savings Foundation; Northfield Bank
Foundation
FX This work was supported by the NYS Office for People with Developmental
Disabilities, the Rural India Charitable Trust, Richmond County Savings
Foundation and Northfield Bank Foundation.
CR AHLSEN G, 1993, BIOL PSYCHIAT, V33, P734, DOI 10.1016/0006-3223(93)90124-V
Anderova M, 2001, GLIA, V35, P189, DOI 10.1002/glia.1084
Ashwood P, 2006, J NEUROIMMUNOL, V173, P126, DOI 10.1016/j.jneuroim.2005.12.007
Ballas U, 2009, NAT NEUROSCI, V12, P311
BAORTO DM, 1992, J CELL BIOL, V117, P357, DOI 10.1083/jcb.117.2.357
Bechmann I, 2007, TRENDS IMMUNOL, V28, P5, DOI 10.1016/j.it.2006.11.007
Bolivar VJ, 2007, BEHAV BRAIN RES, V176, P21, DOI 10.1016/j.bbr.2006.09.007
Chahrour M, 2007, NEURON, V56, P422, DOI 10.1016/j.neuron.2007.10.001
Chez MG, 2007, PEDIATR NEUROL, V36, P361, DOI 10.1016/j.pediatrneurol.2007.01.012
Croonenberghs J, 2002, NEUROPSYCHOBIOLOGY, V45, P1, DOI 10.1159/000048665
Danbolt NC, 2001, PROG NEUROBIOL, V65, P1, DOI 10.1016/S0301-0082(00)00067-8
Farias GG, 2010, DEV DYNAM, V239, P94, DOI 10.1002/dvdy.22065
Farina C, 2007, TRENDS IMMUNOL, V28, P138, DOI 10.1016/j.it.2007.01.005
Fatemi SH, 2008, SYNAPSE, V62, P501, DOI 10.1002/syn.20519
Freeman MR, 2010, SCIENCE, V330, P774, DOI 10.1126/science.1190928
Gilbert M, 2001, GLIA, V34, P151, DOI 10.1002/glia.1050
Graf ER, NEUREXINS INDUCE DIF
Herx LM, 2001, J NEUROPATH EXP NEUR, V60, P961
Herx LM, 2000, J IMMUNOL, V165, P2232
Hirabayashi Y, 2004, DEVELOPMENT, V131, P2791, DOI 10.1242/dev.01165
Hughes EG, 2010, MOL CELL NEUROSCI, V43, P136, DOI 10.1016/j.mcn.2009.10.004
Hughes EG, 2004, MOL BRAIN RES, V124, P114, DOI 10.1016/j.molbrainres.2004.02.021
Ingh VK, 1996, J NEUROIMMUNOL, V66, P143
Israsena N, 2004, DEV BIOL, V268, P220, DOI 10.1016/j.ydbio.2003.12.024
Jamain S, 2003, NAT GENET, V34, P27, DOI 10.1038/ng1136
Jyonouchi H, 2001, J NEUROIMMUNOL, V120, P170, DOI 10.1016/S0165-5728(01)00421-0
Kettenmann H, 2011, FORTSCHR NEUROL PSYC, V79, P588, DOI 10.1055/s-0031-1281704
L'Episcopo F, 2011, MOL NEURODEGENER, V6, DOI 10.1186/1750-1326-6-49
Laurence JA, 2005, CEREBELLUM, V4, P206, DOI 10.1080/14734220500208846
Levinson JN, 2010, NEUROSCIENCE, V165, P782, DOI 10.1016/j.neuroscience.2009.11.016
Li XH, 2009, J NEUROIMMUNOL, V207, P111, DOI 10.1016/j.jneuroim.2008.12.002
Lioy DT, 2011, NATURE, V475, P497, DOI 10.1038/nature10214
Machon O, 2007, DEV BIOL, V311, P223, DOI 10.1016/j.ydbio.2007.08.038
Marui T, 2010, INT J NEUROPSYCHOPH, V13, P443, DOI 10.1017/S1461145709990903
Mason JL, 2001, J NEUROSCI, V21, P7046
McFarlane HG, 2008, GENES BRAIN BEHAV, V7, P152, DOI 10.1111/j.1601-183X.2007.00330.x
Miller FD, 2007, NEURON, V54, P357, DOI 10.1016/j.neuron.2007.04.019
Moy SS, 2007, BEHAV BRAIN RES, V176, P4, DOI 10.1016/j.bbr.2006.07.030
Pekny M, 2004, J PATHOL, V204, P428, DOI 10.1002/path.1645
Penkowa M, 1999, GLIA, V25, P343
Shelley J, 2010, BMC NEUROSCI, V11, P132
Silverman JL, 2009, NEUROPSYCHOPHARMACOL, V35, P976, DOI DOI 10.1038/NPP.2009.201
Stephenson DT, 2011, MOL AUTISM, V2, DOI 10.1186/2040-2392-2-7
STOSCHECK CM, 1990, METHOD ENZYMOL, V182, P50
Sullivan R, 2004, GLIA, V45, P155, DOI 10.1002/glia.10317
Swartz KR, 2001, BRAIN RES, V896, P86, DOI 10.1016/S0006-8993(01)02013-3
Tabuchi K, 2007, SCIENCE, V318, P71, DOI 10.1126/science.1146221
Thomas NS, 1999, HUM GENET, V104, P43, DOI 10.1007/s004390050908
Torres-Platas SG, 2011, NEUROPSYCHOPHARMACOL, V36, P2650, DOI 10.1038/npp.2011.154
Vargas DL, 2005, ANN NEUROL, V57, P67, DOI 10.1002/ana.20315
Varoqueaux F, 2006, NEURON, V51, P741, DOI 10.1016/j.neuron.2006.09.003
Wassink TH, 2001, AM J MED GENET, V105, P406, DOI 10.1002/ajmg.1401
White BD, 2010, STEM CELLS, V28, P297, DOI 10.1002/stem.268
Zhang C, 2009, J NEUROSCI, V29, P10843, DOI 10.1523/JNEUROSCI.1248-09.2009
Zhou CJ, 2004, J NEUROSCI, V24, P121, DOI 10.1523/JNEUROSCI.4071-03.2004
Zhou CJ, 2006, NEUROSCIENCE, V142, P1119, DOI 10.1016/j.neuroscience.2006.07.007
NR 56
TC 9
Z9 10
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1742-2094
J9 J NEUROINFLAMM
JI J. Neuroinflamm.
PD SEP 21
PY 2012
VL 9
AR 223
DI 10.1186/1742-2094-9-223
PG 11
WC Immunology; Neurosciences
SC Immunology; Neurosciences & Neurology
GA 087GV
UT WOS:000314750400001
PM 22999633
ER
PT J
AU Han, S
Tai, C
Westenbroek, RE
Yu, FH
Cheah, CS
Potter, GB
Rubenstein, JL
Scheuer, T
de la Iglesia, HO
Catterall, WA
AF Han, Sung
Tai, Chao
Westenbroek, Ruth E.
Yu, Frank H.
Cheah, Christine S.
Potter, Gregory B.
Rubenstein, John L.
Scheuer, Todd
de la Iglesia, Horacio O.
Catterall, William A.
TI Autistic-like behaviour in Scn1a(+/-) mice and rescue by enhanced
GABA-mediated neurotransmission
SO NATURE
LA English
DT Article
ID SEVERE MYOCLONIC EPILEPSY; DE-NOVO MUTATIONS; REDUCED SODIUM CURRENT;
FRAGILE-X-SYNDROME; DRAVET-SYNDROME; MOUSE MODEL; SPECTRUM DISORDERS;
NA(V)1.1 CHANNELS; RETT-SYNDROME; INFANCY
AB Haploinsufficiency of the SCN1A gene encoding voltage-gated sodium channel Na(V)1.1 causes Dravet's syndrome, a childhood neuropsychiatric disorder including recurrent intractable seizures, cognitive deficit and autism-spectrum behaviours. The neural mechanisms responsible for cognitive deficit and autism-spectrum behaviours in Dravet's syndrome are poorly understood. Here we report that mice with Scn1a haploinsufficiency exhibit hyperactivity, stereotyped behaviours, social interaction deficits and impaired context-dependent spatial memory. Olfactory sensitivity is retained, but novel food odours and social odours are aversive to Scn1a(+/-) mice. GABAergic neurotransmission is specifically impaired by this mutation, and selective deletion of Na(V)1.1 channels in forebrain interneurons is sufficient to cause these behavioural and cognitive impairments. Remarkably, treatment with low-dose clonazepam, a positive allosteric modulator of GABA(A) receptors, completely rescued the abnormal social behaviours and deficits in fear memory in the mouse model of Dravet's syndrome, demonstrating that they are caused by impaired GABAergic neurotransmission and not by neuronal damage from recurrent seizures. These results demonstrate a critical role for Na(V)1.1 channels in neuropsychiatric functions and provide a potential therapeutic strategy for cognitive deficit and autism-spectrum behaviours in Dravet's syndrome.
C1 [Han, Sung; de la Iglesia, Horacio O.; Catterall, William A.] Univ Washington, Graduate Program Neurobiol & Behav, Seattle, WA 98195 USA.
[Han, Sung; Tai, Chao; Westenbroek, Ruth E.; Yu, Frank H.; Cheah, Christine S.; Scheuer, Todd; Catterall, William A.] Univ Washington, Dept Pharmacol, Seattle, WA 98195 USA.
[Han, Sung; de la Iglesia, Horacio O.] Univ Washington, Dept Biol, Seattle, WA 98195 USA.
[Potter, Gregory B.; Rubenstein, John L.] Univ Calif San Francisco, Dept Psychiat, San Francisco, CA 94158 USA.
RP Catterall, WA (reprint author), Univ Washington, Graduate Program Neurobiol & Behav, Seattle, WA 98195 USA.
EM horaciod@uw.edu; wcatt@uw.edu
FU National Institutes of Health [R01 NS25704, R01 MH075016, R37 MH049428];
McKnight Foundation
FX This work was supported by Research Grants R01 NS25704 (W. A. C.), R01
MH075016 (H.O.d.) and R37 MH049428 (J.L.R.) from the National Institutes
of Health and by a grant from the McKnight Foundation (W. A. C.). The
authors thank E. Strakbein in the Machine Division at the University of
Washington for making all the mazes for the behavioural experiments in
this study.
CR Abrahams BS, 2008, NAT REV GENET, V9, P341, DOI 10.1038/nrg2346
Besag FMC, 2004, EPILEPSY BEHAV, V5, P3, DOI 10.1016/j.yebeh.2003.11.002
Brunklaus A, 2011, EPILEPSIA, V52, P1476, DOI 10.1111/j.1528-1167.2011.03129.x
Catterall WA, 2000, NEURON, V26, P13, DOI 10.1016/S0896-6273(00)81133-2
Catterall WA, 2010, J PHYSIOL-LONDON, V588, P1849, DOI 10.1113/jphysiol.2010.187484
Chao HT, 2010, NATURE, V468, P263, DOI 10.1038/nature09582
Cheah C. S., P NATL ACAD IN PRESS
Claes L, 2001, AM J HUM GENET, V68, P1327, DOI 10.1086/320609
Genton P, 2011, EPILEPSIA, V52, P44, DOI 10.1111/j.1528-1167.2011.03001.x
Geschwind DH, 2011, TRENDS COGN SCI, V15, P409, DOI 10.1016/j.tics.2011.07.003
Gomot M, 2006, NEUROIMAGE, V29, P475, DOI 10.1016/j.neuroimage.2005.07.027
Han S, 2012, P NATL ACAD SCI USA, V109, pE368, DOI 10.1073/pnas.1115729109
Hussman JP, 2001, J AUTISM DEV DISORD, V31, P247, DOI 10.1023/A:1010715619091
Kalume F, 2007, J NEUROSCI, V27, P11065, DOI 10.1523/JNEUROSCI.2162-07.2007
Li BM, 2011, EPILEPSY BEHAV, V21, P291, DOI 10.1016/j.yebeh.2011.04.060
Long J. E., 2009, CEREB CORTEX S1, V19, pi96, DOI 10.1093/cercor/bhp045bhp045
Low K, 2000, SCIENCE, V290, P131, DOI 10.1126/science.290.5489.131
Mahoney K, 2009, SEIZURE-EUR J EPILEP, V18, P492, DOI 10.1016/j.seizure.2009.04.009
Markram K, 2010, FRONT HUM NEUROSCI, V4, DOI 10.3389/fnhum.2010.00224
Moretti P, 2005, HUM MOL GENET, V14, P205, DOI 10.1093/hmg/ddi016
Oakley JC, 2009, P NATL ACAD SCI USA, V106, P3994, DOI 10.1073/pnas.0813330106
Ogiwara I, 2007, J NEUROSCI, V27, P5903, DOI 10.1523/JNEUROSCI.5270-06.2007
O'Roak BJ, 2012, NATURE, V485, P246, DOI 10.1038/nature10989
O'Roak BJ, 2011, NAT GENET, V43, P585, DOI 10.1038/ng.835
Paluszkiewicz SM, 2011, DEV NEUROSCI-BASEL, V33, P349, DOI 10.1159/000329420
Paluszkiewicz SM, 2011, J NEUROPHYSIOL, V106, P2264, DOI 10.1152/jn.00421.2011
Penagarikano O, 2011, CELL, V147, P235, DOI 10.1016/j.cell.2011.08.040
Pescucci C, 2007, EUR J MED GENET, V50, P21, DOI 10.1016/j.ejmg.2006.09.001
Potter GB, 2009, MOL CELL NEUROSCI, V40, P167, DOI 10.1016/j.mcn.2008.10.003
Ramoz N, 2008, AM J MED GENET B, V147B, P1152, DOI 10.1002/ajmg.b.30739
Rossignol E, 2011, NEURAL PLAST, DOI 10.1155/2011/649325
Rubenstein JLR, 2003, GENES BRAIN BEHAV, V2, P255, DOI 10.1046/j.1601-183X.2003.00037.x
Rudolph U, 2011, NAT REV DRUG DISCOV, V10, P685, DOI 10.1038/nrd3502
Silverman JL, 2010, NAT REV NEUROSCI, V11, P490, DOI 10.1038/nrn2851
Stockhorst U, 2004, PHYSIOL BEHAV, V83, P3, DOI 10.1016/j.physbeh.2004.07.018
Van Wart A, 2007, J COMP NEUROL, V500, P339, DOI 10.1002/cne.21173
Wang ZS, 2006, J NEUROSCI, V26, P7375, DOI 10.1523/JNEUROSCI.1967-06.2006
Weiss LA, 2003, MOL PSYCHIATR, V8, P186, DOI 10.1038/sj.mp.4001241
WESTENBROEK RE, 1989, NEURON, V3, P695, DOI 10.1016/0896-6273(89)90238-9
Wolff M, 2006, EPILEPSIA, V47, P45, DOI 10.1111/j.1528-1167.2006.00688.x
YAKOUB M, 1992, BRAIN DEV-JPN, V14, P299
Yang M, 2012, PHYSL BEHAV
Yizhar O, 2011, NATURE, V477, P171, DOI 10.1038/nature10360
Yu FH, 2006, NAT NEUROSCI, V9, P1142, DOI 10.1038/nn1754
NR 44
TC 81
Z9 83
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0028-0836
J9 NATURE
JI Nature
PD SEP 20
PY 2012
VL 489
IS 7416
BP 385
EP 390
DI 10.1038/nature11356
PG 6
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 007AK
UT WOS:000308860900036
PM 22914087
ER
PT J
AU Uhlhaas, PJ
Singer, W
AF Uhlhaas, Peter J.
Singer, Wolf
TI Neuronal Dynamics and Neuropsychiatric Disorders: Toward a Translational
Paradigm for Dysfunctional Large-Scale Networks
SO NEURON
LA English
DT Review
ID NMDA RECEPTOR HYPOFUNCTION; AUTISM SPECTRUM DISORDERS; HIPPOCAMPUS
IN-VITRO; GAMMA-BAND SYNCHRONIZATION; MONKEY PREFRONTAL CORTEX; PRIMARY
VISUAL-CORTEX; LONG-RANGE SYNCHRONY; OSCILLATORY ACTIVITY; NEURAL
SYNCHRONY; WORKING-MEMORY
AB In recent years, numerous studies have tested the relevance of neural oscillations in neuropsychiatric conditions, highlighting the potential role of changes in temporal coordination as a pathophysiological mechanism in brain disorders. In the current review, we provide an update on this hypothesis because of the growing evidence that temporal coordination is essential for the context and goal-dependent, dynamic formation of large-scale cortical networks. We shall focus on issues that we consider particularly promising for a translational research program aimed at furthering our understanding of the origins of neuropsychiatric disorders and the development of effective therapies. We will focus on schizophrenia and autism spectrum disorders (ASDs) to highlight important issues and challenges for the implementation of such an approach. Specifically, we will argue that deficits in temporal coordination lead to a disruption of functional large-scale networks, which in turn can account for several specific dysfunctions associated with these disorders.
C1 [Uhlhaas, Peter J.; Singer, Wolf] Max Planck Inst Brain Res, Dept Neurophysiol, D-60528 Frankfurt, Germany.
[Uhlhaas, Peter J.; Singer, Wolf] Max Planck Gesell, Ernst Strungmann Inst Neurosci, D-60528 Frankfurt, Germany.
[Uhlhaas, Peter J.] Univ Glasgow, Inst Neurosci & Psychol, Glasgow G12 80B, Lanark, Scotland.
[Singer, Wolf] Goethe Univ Frankfurt, Frankfurt Inst Adv Studies, D-60528 Frankfurt, Germany.
RP Uhlhaas, PJ (reprint author), Max Planck Inst Brain Res, Dept Neurophysiol, Deutschordenstr 46, D-60528 Frankfurt, Germany.
EM peter.uhlhaas@glasgow.ac.uk
RI Singer, Wolf/D-6874-2012
FU Max-Planck Society; LOEWE Grant "Neuronale Koordination
Forschungsschwerpunkt Frankfurt"
FX This work was supported by the Max-Planck Society and the LOEWE Grant
"Neuronale Koordination Forschungsschwerpunkt Frankfurt." We thank
Chalid Hasan for his help in preparing Table 1.
CR Anver H, 2011, NEUROPSYCHOPHARMACOL, V36, P519, DOI 10.1038/npp.2010.183
Bartos M, 2007, NAT REV NEUROSCI, V8, P45, DOI 10.1038/nrn2044
Barttfeld P, 2011, NEUROPSYCHOLOGIA, V49, P254, DOI 10.1016/j.neuropsychologia.2010.11.024
Behrens MM, 2007, SCIENCE, V318, P1645, DOI 10.1126/science.1148045
Belforte JE, 2010, NAT NEUROSCI, V13, P76, DOI 10.1038/nn.2447
BENARI Y, 1989, J PHYSIOL-LONDON, V416, P303
Bleuler E, 1911, DEMENTIA PRAECOX GRO
Bonifazi P, 2009, SCIENCE, V326, P1419, DOI 10.1126/science.1175509
Brockmann MD, 2011, NEURON, V71, P332, DOI 10.1016/j.neuron.2011.05.041
Buchanan RW, 2011, BIOL PSYCHIAT, V69, P442, DOI 10.1016/j.biopsych.2010.09.052
BUHL EH, 1989, EXP BRAIN RES, V75, P470
Bullmore ET, 2009, NAT REV NEUROSCI, V10, P186, DOI 10.1038/nrn2575
Buschman TJ, 2007, SCIENCE, V315, P1860, DOI 10.1126/science.1138071
Buzsaki G, 2004, SCIENCE, V304, P1926, DOI 10.1126/science.1099745
Canolty RT, 2010, TRENDS COGN SCI, V14, P506, DOI 10.1016/j.tics.2010.09.001
Canolty RT, 2006, SCIENCE, V313, P1626, DOI 10.1126/science.1128115
Cardin JA, 2009, NATURE, V459, P663, DOI 10.1038/nature08002
Carl C, 2012, NEUROIMAGE, V59, P1657, DOI 10.1016/j.neuroimage.2011.09.020
Carlen M, 2012, MOL PSYCHIATR, V17, P537, DOI 10.1038/mp.2011.31
Carlson GC, 2011, P NATL ACAD SCI USA, V108, pE962, DOI 10.1073/pnas.1109625108
Chao HT, 2010, NATURE, V468, P263, DOI 10.1038/nature09582
Chaumon M, 2009, J COGNITIVE NEUROSCI, V21, P2287, DOI 10.1162/jocn.2008.21155
Choudhury PR, 2012, PHARMACOL BIOCHEM BE, V100, P841, DOI 10.1016/j.pbb.2011.06.023
Colgin LL, 2011, CURR OPIN NEUROBIOL, V21, P467, DOI 10.1016/j.conb.2011.04.006
Collins PY, 2011, NATURE, V475, P27, DOI 10.1038/475027a
Crone NE, 2001, CLIN NEUROPHYSIOL, V112, P565, DOI 10.1016/S1388-2457(00)00545-9
Crone NE, 2011, INT J PSYCHOPHYSIOL, V79, P9, DOI 10.1016/j.ijpsycho.2010.10.013
Cruz DA, 2003, J COMP NEUROL, V465, P385, DOI 10.1002/cne.10833
Cunningham MO, 2003, J NEUROSCI, V23, P9761
Dakin S, 2005, NEURON, V48, P497, DOI 10.1016/j.neuron.2005.10.018
Deco G, 2011, NAT REV NEUROSCI, V12, P43, DOI 10.1038/nrn2961
DELRIO JA, 1994, DEV BRAIN RES, V81, P247, DOI 10.1016/0165-3806(94)90311-5
Demiralp T, 2007, CEREB CORTEX, V17, P1007, DOI 10.1093/cereor/bhl011
Dinstein I, 2011, NEURON, V70, P1218, DOI 10.1016/j.neuron.2011.04.018
Dzirasa K, 2009, J NEUROSCI, V29, P8215, DOI 10.1523/JNEUROSCI.1773-09.2009
Erickson SL, 2002, J COMP NEUROL, V448, P186, DOI 10.1002/cne.10249
Fagiolini M, 2000, NATURE, V404, P183
Fatemi SH, 2002, BIOL PSYCHIAT, V52, P805, DOI 10.1016/S0006-3223(02)01430-0
Fisahn A, 2009, CEREB CORTEX, V19, P612, DOI 10.1093/cercor/bhn107
Ford JM, 2008, BIOL PSYCHIAT, V63, P736, DOI 10.1016/j.biopsych.2007.09.013
Fornito A, 2012, NEUROIMAGE, V62, P2296, DOI 10.1016/j.neuroimage.2011.12.090
Fries P, 2005, TRENDS COGN SCI, V9, P474, DOI 10.1016/j.tics.2005.08.011
Fries P, 2009, ANNU REV NEUROSCI, V32, P209, DOI 10.1146/annurev.neuro.051508.135603
Friston KJ, 1998, SCHIZOPHR RES, V30, P115, DOI 10.1016/S0920-9964(97)00140-0
Fuchs EC, 2001, P NATL ACAD SCI USA, V98, P3571, DOI 10.1073/pnas.051631898
Gandal MJ, 2010, BIOL PSYCHIAT, V68, P1100, DOI 10.1016/j.biopsych.2010.09.031
Geiger JRP, 1997, NEURON, V18, P1009, DOI 10.1016/S0896-6273(00)80339-6
Geschwind DH, 2007, CURR OPIN NEUROBIOL, V17, P103, DOI 10.1016/j.conb.2007.01.009
Goffin D, 2012, NAT NEUROSCI, V15, P274, DOI 10.1038/nn.2997
Gogolla N, 2009, J NEURODEV DISORD, V1, P172, DOI 10.1007/s11689-009-9023-x
Gonzalez-Burgos G., 2012, SCHIZOPHR B
GRAY CM, 1989, NATURE, V338, P334, DOI 10.1038/338334a0
Grutzner C, 2010, J NEUROSCI, V30, P8342, DOI 10.1523/JNEUROSCI.5434-09.2010
Guilmatre A, 2009, ARCH GEN PSYCHIAT, V66, P947, DOI 10.1001/archgenpsychiatry.2009.80
Haenschel C, 2009, J NEUROSCI, V29, P9481, DOI 10.1523/JNEUROSCI.1428-09.2009
Hall MH, 2011, SCHIZOPHRENIA BULL, V37, P778, DOI 10.1093/schbul/sbp134
Hashimoto T, 2009, BIOL PSYCHIAT, V65, P1015, DOI 10.1016/j.biopsych.2009.01.004
Hensch TK, 2005, NAT REV NEUROSCI, V6, P877, DOI 10.1038/nrn1787
Heresco-Levy U, 2004, BIOL PSYCHIAT, V55, P165, DOI 10.1016/S0006-3223(03)00707-8
Hill SK, 2008, SCHIZOPHRENIA BULL, V34, P743, DOI 10.1093/schbul/sbn027
Hipp JF, 2011, NEURON, V69, P387, DOI 10.1016/j.neuron.2010.12.027
Hipp JF, 2012, NAT NEUROSCI, V15, P884, DOI 10.1038/nn.3101
Hirano S, 2008, J NEUROSCI, V28, P4897, DOI 10.1523/JNEUROSCI.5031-07.2008
Ho BC, 2011, ARCH GEN PSYCHIAT, V68, P128, DOI 10.1001/archgenpsychiatry.2010.199
HOFFMAN RE, 1993, SCHIZOPHRENIA BULL, V19, P119
Homayoun H, 2007, J NEUROSCI, V27, P11496, DOI 10.1523/JNEUROSCI.2213-07.2007
Hong LE, 2010, NEUROPSYCHOPHARMACOL, V35, P632, DOI 10.1038/npp.2009.168
Hong LE, 2008, ARCH GEN PSYCHIAT, V65, P1008, DOI 10.1001/archpsyc.65.9.1008
Hunt MJ, 2011, J PSYCHOPHARMACOL, V25, P808, DOI 10.1177/0269881110362126
Insel TR, 2009, ARCH GEN PSYCHIAT, V66, P128, DOI 10.1001/archgenpsychiatry.2008.540
Iwai Y, 2003, J NEUROSCI, V23, P6695
Jensen O, 2007, TRENDS COGN SCI, V11, P267, DOI 10.1016/j.tics.2007.05.003
Jentsch JD, 1999, NEUROPSYCHOPHARMACOL, V20, P201, DOI 10.1016/S0893-133X(98)00060-8
Jinno S, 2007, J NEUROSCI, V27, P8790, DOI 10.1523/JNEUROSCI.1847-07.2007
Jokisch D, 2007, J NEUROSCI, V27, P3244, DOI 10.1523/JNEUROSCI.5399-06.2007
Kantrowitz JT, 2010, BRAIN RES BULL, V83, P108, DOI [10.1016/j.brainresbull.2010.04.006, 10.1016/j.brainresbull.2010.06.006]
Katz LC, 1996, SCIENCE, V274, P1133, DOI 10.1126/science.274.5290.1133
Kegeles LS, 2012, ARCH GEN PSYCHIAT, V69, P449, DOI 10.1001/archgenpsychiatry.2011.1519
Khazipov R, 2006, TRENDS NEUROSCI, V29, P414, DOI 10.1016/j.tins.2006.05.007
Kikuchi M, 2011, SCHIZOPHR RES, V130, P187, DOI 10.1016/j.schres.2011.06.003
Kinney JW, 2006, J NEUROSCI, V26, P1604, DOI 10.1523/JNEUROSCI.4722-05.2006
Kittelberger K, 2012, BRAIN STRUCT FUNCT, V217, P395, DOI 10.1007/s00429-011-0351-8
Klosterkotter J, 2001, ARCH GEN PSYCHIAT, V58, P158, DOI 10.1001/archpsyc.58.2.158
Kocsis B, 2012, BIOL PSYCHIAT, V71, P987, DOI 10.1016/j.biopsych.2011.10.002
Kopell N, 2000, P NATL ACAD SCI USA, V97, P1867, DOI 10.1073/pnas.97.4.1867
Korotkova T, 2010, NEURON, V68, P557, DOI 10.1016/j.neuron.2010.09.017
Krause M, 2005, NEUROPHARMACOLOGY, V48, P381, DOI 10.1016/j.neuropharm.2004.10.011
Kwon JS, 1999, ARCH GEN PSYCHIAT, V56, P1001, DOI 10.1001/archpsyc.56.11.1001
Lee SH, 2006, SCHIZOPHR RES, V83, P111, DOI 10.1016/j.schres.2005.11.025
Lenz D, 2011, INT J PSYCHOPHYSIOL, V79, P25, DOI 10.1016/j.ijpsycho.2010.08.002
Lewis DA, 2012, TRENDS NEUROSCI, V35, P57, DOI 10.1016/j.tins.2011.10.004
Lieberman JA, 2005, NEW ENGL J MED, V353, P1209, DOI 10.1056/NEJMoa051688
Lima B, 2011, J NEUROSCI, V31, P15919, DOI 10.1523/JNEUROSCI.0957-11.2011
Linkenkaer-Hansen K, 2007, J NEUROSCI, V27, P13882, DOI 10.1523/JNEUROSCI.3083-07.2007
Lodge DJ, 2009, J NEUROSCI, V29, P2344, DOI 10.1523/JNEUROSCI.5419-08.2009
LUHMANN HJ, 1991, J NEUROPHYSIOL, V65, P247
Manns ID, 2000, J NEUROSCI, V20, P1505
Markram K, 2010, FRONT HUM NEUROSCI, V4, DOI 10.3389/fnhum.2010.00224
MEISTER M, 1991, SCIENCE, V252, P939, DOI 10.1126/science.2035024
Melzer S., 2012, SCIENCE, V335, P1508
Meyer-Lindenberg AS, 2005, ARCH GEN PSYCHIAT, V62, P379, DOI 10.1001/archpsyc.62.4.379
Milne E, 2009, BIOL PSYCHIAT, V65, P22, DOI 10.1016/j.biopsych.2008.07.017
Minzenberg MJ, 2010, NEUROPSYCHOPHARMACOL, V35, P2590, DOI 10.1038/npp.2010.150
MONAGHAN DT, 1985, J NEUROSCI, V5, P2909
Montague PR, 2012, TRENDS COGN SCI, V16, P72, DOI 10.1016/j.tics.2011.11.018
Moore SJ, 2000, J MED GENET, V37, P489, DOI 10.1136/jmg.37.7.489
Mulert C, 2011, INT J PSYCHOPHYSIOL, V79, P55, DOI 10.1016/j.ijpsycho.2010.08.004
Murias M, 2007, CEREB CORTEX, V17, P1788, DOI 10.1093/cercor/bhl089
Neymotin SA, 2011, J NEUROSCI, V31, P11733, DOI 10.1523/JNEUROSCI.0501-11.2011
Oblak AL, 2010, J NEUROCHEM, V114, P1414, DOI 10.1111/j.1471-4159.2010.06858.x
O'Donnell BF, 2004, INT J PSYCHOPHYSIOL, V53, P45, DOI 10.1016/j.ijpsycho.2004.02.001
Ozerdem A, 2010, PROG NEURO-PSYCHOPH, V34, P861, DOI 10.1016/j.pnpbp.2010.04.001
Palva JM, 2010, P NATL ACAD SCI USA, V107, P7580, DOI 10.1073/pnas.0913113107
Palva S, 2012, TRENDS COGN SCI, V16, P219, DOI 10.1016/j.tics.2012.02.004
Phillips KG, 2012, NEUROPHARMACOLOGY, V62, P1359, DOI 10.1016/j.neuropharm.2011.04.006
Plourde G, 1997, BRIT J ANAESTH, V78, P524
Polania R, 2012, CURR BIOL, V22, P1314, DOI 10.1016/j.cub.2012.05.021
Rinaldi T, 2007, P NATL ACAD SCI USA, V104, P13501, DOI 10.1073/pnas.0704391104
Rodriguez R, 2004, J NEUROSCI, V24, P10369, DOI 10.1523/JNEUROSCI.1839-04.2004
Roopun AK, 2008, FRONT CELL NEUROSCI, V2, DOI 10.3389/neuro.03.001.2008
ROSIER AM, 1993, J COMP NEUROL, V335, P369, DOI 10.1002/cne.903350307
Roux F, 2012, J NEUROSCI, V32, P12411, DOI 10.1523/JNEUROSCI.0421-12.2012
Rubenstein JLR, 2003, GENES BRAIN BEHAV, V2, P255, DOI 10.1046/j.1601-183X.2003.00037.x
Saalmann YB, 2012, SCIENCE, V337, P753, DOI 10.1126/science.1223082
Saunders JA, 2012, NEUROBIOL DIS, V46, P93, DOI 10.1016/j.nbd.2011.12.049
Schipul Sarah E, 2011, Front Syst Neurosci, V5, P10, DOI 10.3389/fnsys.2011.00010
Shukla DK, 2011, NEUROPSYCHOLOGIA, V49, P1378, DOI 10.1016/j.neuropsychologia.2011.02.022
Siegel M, 2012, NAT REV NEUROSCI, V13, P121, DOI 10.1038/nrn3137
Sigurdsson T, 2010, NATURE, V464, P763, DOI 10.1038/nature08855
SINGER W, 1995, SCIENCE, V270, P758, DOI 10.1126/science.270.5237.758
Sohal VS, 2009, NATURE, V459, P698, DOI 10.1038/nature07991
Spencer KM, 2003, J NEUROSCI, V23, P7407
Spencer KM, 2012, FRONT HUM NEUROSCI, V5, DOI 10.3389/fnhum.2011.00190
Steullet P, 2010, J NEUROSCI, V30, P2547, DOI 10.1523/JNEUROSCI.3857-09.2010
Stroganova TA, 2012, CORTEX, V48, P701, DOI 10.1016/j.cortex.2011.02.016
Sturman DA, 2011, J NEUROSCI, V31, P1471, DOI 10.1523/JNEUROSCI.4210-10.2011
Sun LM, 2012, J NEUROSCI, V32, P9563, DOI 10.1523/JNEUROSCI.1073-12.2012
Tiihonen J, 2009, LANCET, V374, P620, DOI 10.1016/S0140-6736(09)60742-X
Traub RD, 2004, ANNU REV NEUROSCI, V27, P247, DOI 10.1146/annurev.neuro.27.070203.144303
Traub RD, 1996, J PHYSIOL-LONDON, V493, P471
Tseng KY, 2007, CEREB CORTEX, V17, P1235, DOI 10.1093/cercor/bhl034
Tuchman R, 2002, LANCET NEUROL, V1, P352, DOI 10.1016/S1474-4422(02)00160-6
Uhlhaas PJ, 2010, TRENDS COGN SCI, V14, P72, DOI 10.1016/j.tics.2009.12.002
Uhlhaas Peter J, 2009, Front Integr Neurosci, V3, P17, DOI 10.3389/neuro.07.017.2009
Uhlhaas PJ, 2011, SCHIZOPHRENIA BULL, V37, P514, DOI 10.1093/schbul/sbr034
Uhlhaas PJ, 2007, BIOL PSYCHIAT, V62, P190, DOI 10.1016/j.biopsych.2007.05.023
Uhlhaas PJ, 2010, NAT REV NEUROSCI, V11, P100, DOI 10.1038/nrn2774
Uhlhaas PJ, 2006, J NEUROSCI, V26, P8168, DOI 10.1523/JNEUROSCI.2002-06.2006
Uhlhaas PJ, 2009, P NATL ACAD SCI USA, V106, P9866, DOI 10.1073/pnas.0900390106
Uhlhaas PJ, 2011, SCHIZOPHRENIA BULL, V37, P480, DOI 10.1093/schbul/sbr025
Uhlhaas PJ, 2011, PROG BIOPHYS MOL BIO, V105, P14, DOI 10.1016/j.pbiomolbio.2010.10.004
van Pelt S, 2012, J NEUROSCI, V32, P3388, DOI 10.1523/JNEUROSCI.5592-11.2012
Varela F, 2001, NAT REV NEUROSCI, V2, P229, DOI 10.1038/35067550
Vicente R, 2008, P NATL ACAD SCI USA, V105, P17157, DOI 10.1073/pnas.0809353105
Vidal JR, 2006, J COGNITIVE NEUROSCI, V18, P1850, DOI 10.1162/jocn.2006.18.11.1850
Voineagu I, 2011, NATURE, V474, P380, DOI 10.1038/nature10110
Volman V, 2011, J NEUROSCI, V31, P18137, DOI 10.1523/JNEUROSCI.3041-11.2011
von Stein A, 2000, INT J PSYCHOPHYSIOL, V38, P301, DOI 10.1016/S0167-8760(00)00172-0
Wang DD, 2009, J PHYSIOL-LONDON, V587, P1873, DOI 10.1113/jphysiol.2008.167635
Wang HX, 2009, NEUROPSYCHOPHARMACOL, V34, P2028, DOI 10.1038/npp.2009.20
Wang XJ, 1996, J NEUROSCI, V16, P6402
Wernicke C, 1906, GRUNDRISSE PSYCHIAT
WHITE PF, 1982, ANESTHESIOLOGY, V56, P119, DOI 10.1097/00000542-198202000-00007
Whithain EM, 2007, CLIN NEUROPHYSIOL, V118, P1877, DOI 10.1016/j.clinph.2007.04.027
WHITTINGTON MA, 1995, NATURE, V373, P612, DOI 10.1038/373612a0
Wilson TW, 2007, BIOL PSYCHIAT, V62, P192, DOI 10.1016/j.biopsych.2007.07.002
Wittchen HU, 2011, EUR NEUROPSYCHOPHARM, V21, P655, DOI 10.1016/j.euroneuro.2011.07.018
Wojtowicz AM, 2009, HIPPOCAMPUS, V19, P273, DOI 10.1002/hipo.20508
Womelsdorf T, 2007, SCIENCE, V316, P1609, DOI [10.1126/science.1139597, 10.1126/science.1139178]
Wood SJ, 2011, BIOL PSYCHIAT, V70, P619, DOI 10.1016/j.biopsych.2011.05.034
Yung AR, 1996, AUST NZ J PSYCHIAT, V30, P587, DOI 10.3109/00048679609062654
Yuval-Greenberg S, 2008, NEURON, V58, P429, DOI 10.1016/j.neuron.2008.03.027
Zhang YC, 2008, J NEUROPHYSIOL, V100, P959, DOI 10.1152/jn.00079.2008
NR 173
TC 75
Z9 76
PU CELL PRESS
PI CAMBRIDGE
PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA
SN 0896-6273
J9 NEURON
JI Neuron
PD SEP 20
PY 2012
VL 75
IS 6
BP 963
EP 980
DI 10.1016/j.neuron.2012.09.004
PG 18
WC Neurosciences
SC Neurosciences & Neurology
GA 011XF
UT WOS:000309198900009
PM 22998866
ER
PT J
AU Dinstein, I
Heeger, DJ
Lorenzi, L
Minshew, NJ
Malach, R
Behrmann, M
AF Dinstein, Ilan
Heeger, David J.
Lorenzi, Lauren
Minshew, Nancy J.
Malach, Rafael
Behrmann, Marlene
TI Unreliable Evoked Responses in Autism
SO NEURON
LA English
DT Article
ID FUNCTIONAL CONNECTIVITY MRI; SPECTRUM DISORDERS; BRAIN; CHILDREN;
DEFICITS; NETWORK; FMRI; HYPEREXCITABILITY; ABNORMALITIES; VARIABILITY
AB Autism has been described as a disorder of general neural processing, but the particular processing characteristics that might be abnormal in autism have mostly remained obscure. Here, we present evidence of one such characteristic: poor evoked response reliability. We compared cortical response amplitude and reliability (consistency across trials) in visual, auditory, and somatosensory cortices of high-functioning individuals with autism and controls. Mean response amplitudes were statistically indistinguishable across groups, yet trial-by-trial response reliability was significantly weaker in autism, yielding smaller signal-to-noise ratios in all sensory systems. Response reliability differences were evident only in evoked cortical responses and not in ongoing resting-state activity. These findings reveal that abnormally unreliable cortical responses, even to elementary nonsocial sensory stimuli, may represent a fundamental physiological alteration of neural processing in autism. The results motivate a critical expansion of autism research to determine whether (and how) basic neural processing properties such as reliability, plasticity, and adaptation/habituation are altered in autism.
C1 [Dinstein, Ilan; Lorenzi, Lauren; Behrmann, Marlene] Carnegie Mellon Univ, Dept Psychol, Pittsburgh, PA 15213 USA.
[Heeger, David J.] NYU, Dept Psychol, New York, NY 10003 USA.
[Heeger, David J.] NYU, Ctr Neural Sci, New York, NY 10003 USA.
[Minshew, Nancy J.] Univ Pittsburgh, Dept Neurol, Pittsburgh, PA 15213 USA.
[Malach, Rafael] Weizmann Inst Sci, Dept Neurobiol, IL-76100 Rehovot, Israel.
RP Dinstein, I (reprint author), Carnegie Mellon Univ, Dept Psychol, Baker Hall, Pittsburgh, PA 15213 USA.
EM ilan@cns.nyu.edu
FU Simons Foundation SFARI grant [177638]; ISF grants; Bikura grant; Clore
and Kahn postdoctoral fellowships; Pennsylvania Department of Health SAP
[4100047862]; NICHD/NIDCD [PO1/U19]; NIH/NICHD University of Pittsburgh
Autism Center of Excellence [HD055748]
FX This work was supported by Simons Foundation SFARI grant 177638 (D.J.H.,
M.B., and I.D.), ISF and Bikura grants (R.M.), Clore and Kahn
postdoctoral fellowships (ID.), Pennsylvania Department of Health SAP
grant 4100047862 and NICHD/NIDCD PO1/U19 (M.B.). This research was also
supported by the NIH/NICHD University of Pittsburgh Autism Center of
Excellence HD055748.
CR [Anonymous], 2000, DIAGNOSTIC STAT MANU
Baron-Cohen S, 2005, ANNU REV NEUROSCI, V28, P109, DOI 10.1146/annurev.neuro.27.070203.144137
Bauman ML, 2005, INT J DEV NEUROSCI, V23, P183, DOI 10.1016/j.ijdevneu.2004.09.006
Belmonte MK, 2004, MOL PSYCHIATR, V9, P646, DOI 10.1038/sj.mp.4001499
Birn RM, 2009, NEUROIMAGE, V47, P1092, DOI 10.1016/j.neuroimage.2009.05.030
Bourgeron T, 2009, CURR OPIN NEUROBIOL, V19, P231, DOI 10.1016/j.conb.2009.06.003
Casanova MF, 2002, NEUROLOGY, V58, P428
Castellanos FX, 2005, BIOL PSYCHIAT, V57, P1416, DOI 10.1016/j.biopsych.2004.12.005
Chiu PH, 2008, NEURON, V57, P463, DOI 10.1016/j.neuron.2007.12.020
COHEN IL, 1994, BIOL PSYCHIAT, V36, P5, DOI 10.1016/0006-3223(94)90057-4
Dakin S, 2005, NEURON, V48, P497, DOI 10.1016/j.neuron.2005.10.018
Dapretto M, 2006, NAT NEUROSCI, V9, P28, DOI 10.1038/nn1611
Dinstein I, 2011, NEURON, V70, P1218, DOI 10.1016/j.neuron.2011.04.018
Dinstein I, 2010, NEURON, V66, P461, DOI 10.1016/j.neuron.2010.03.034
Fox MD, 2006, NAT NEUROSCI, V9, P23, DOI 10.1038/nn1616
Friston K. J., 1993, HUMAN BRAIN MAPPING, V1, P153, DOI 10.1002/hbm.460010207
Friston KJ, 1999, NEUROIMAGE, V10, P385, DOI 10.1006/nimg.1999.0484
Gibson JR, 2008, J NEUROPHYSIOL, V100, P2615, DOI 10.1152/jn.90752.2008
Gilman SR, 2011, NEURON, V70, P898, DOI 10.1016/j.neuron.2011.05.021
Glazebrook CM, 2006, MOTOR CONTROL, V10, P244
Happe F, 2006, J AUTISM DEV DISORD, V36, P5, DOI 10.1007/s10803-005-0039-0
Humphreys K, 2008, AUTISM RES, V1, P52, DOI 10.1002/aur.1
Just MA, 2007, CEREB CORTEX, V17, P951, DOI 10.1093/cercor/bhl006
Kennedy DP, 2008, NEUROIMAGE, V39, P1877, DOI 10.1016/j.neuroimage.2007.10.052
Ben Bashat Dafna, 2007, Neuroimage, V37, P40, DOI 10.1016/j.neuroimage.2007.04.060
Lennie P, 2003, CURR BIOL, V13, P493, DOI 10.1016/S0960-9822(03)00135-0
Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
Markram Henry, 2007, Front Neurosci, V1, P77, DOI 10.3389/neuro.01.1.1.006.2007
McDonnell MD, 2009, PLOS COMPUT BIOL, V5, DOI 10.1371/journal.pcbi.1000348
Milne E, 2011, FRONT PSYCHOL, V2, DOI 10.3389/fpsyg.2011.00051
Minshew N J, 1997, J Int Neuropsychol Soc, V3, P303
Mottron L, 2006, J AUTISM DEV DISORD, V36, P27, DOI 10.1007/s10803-005-0040-7
Pelphrey KA, 2005, BRAIN, V128, P1038, DOI 10.1093/brain/awh404
Penagarikano O, 2011, CELL, V147, P235, DOI 10.1016/j.cell.2011.08.040
Power JD, 2012, NEUROIMAGE, V59, P2142, DOI 10.1016/j.neuroimage.2011.10.018
Redcay E, 2008, BIOL PSYCHIAT, V64, P589, DOI 10.1016/j.biopsych.2008.05.020
Rubenstein JLR, 2003, GENES BRAIN BEHAV, V2, P255, DOI 10.1046/j.1601-183X.2003.00037.x
Simmons DR, 2009, VISION RES, V49, P2705, DOI 10.1016/j.visres.2009.08.005
Takarae Y, 2004, J NEUROL NEUROSUR PS, V75, P1359, DOI 10.1136/jnnp.2003.022491
Talairach J., 1988, COPLANAR STEREOTAXIC
Thomas C, 2011, CORTEX, V47, P863, DOI 10.1016/j.cortex.2010.07.006
Tuchman R, 2002, LANCET NEUROL, V1, P352, DOI 10.1016/S1474-4422(02)00160-6
Van Dijk KRA, 2012, NEUROIMAGE, V59, P431, DOI 10.1016/j.neuroimage.2011.07.044
Whyatt CP, 2012, J AUTISM DEV DISORD, V42, P1799, DOI 10.1007/s10803-011-1421-8
Zhang L, 2008, HIPPOCAMPUS, V18, P294, DOI 10.1002/hipo.20389
Zoghbi HY, 2003, SCIENCE, V302, P826, DOI 10.1126/science.1089071
NR 46
TC 58
Z9 58
PU CELL PRESS
PI CAMBRIDGE
PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA
SN 0896-6273
J9 NEURON
JI Neuron
PD SEP 20
PY 2012
VL 75
IS 6
BP 981
EP 991
DI 10.1016/j.neuron.2012.07.026
PG 11
WC Neurosciences
SC Neurosciences & Neurology
GA 011XF
UT WOS:000309198900010
PM 22998867
ER
PT J
AU Lee, J
Takehashi, H
Nagai, C
Obinata, G
Stefanov, D
AF Lee, Jaeryoung
Takehashi, Hiroki
Nagai, Chikara
Obinata, Goro
Stefanov, Dimitar
TI Which Robot Features Can Stimulate Better Responses from Children with
Autism in Robot-Assisted Therapy?
SO INTERNATIONAL JOURNAL OF ADVANCED ROBOTIC SYSTEMS
LA English
DT Article
DE Human-robot interaction; Robot-assisted therapy; Therapeutic robot;
Autism therapy
ID SOCIAL-INTERACTION; TOYS
AB This study explores the response of autistic children to a few design features of the robots for autism therapy and provides suggestions on the robot features that have a stronger influence on the therapeutic process. First, we investigate the effect of selected robot features on the development of social communication skills in autistic children. The results indicate that the toy's "face" and "moving limb" usually draw the children's attention and improve children's facial expression skills, but do not contribute to the development of other social communication skills. Secondly, we study the response of children with low-functioning autism to robots with verbal communication functionalities. Test results show that children interacted with the verbal-featured robot more intensively than with the experimenter. We conclude that robots with faces and moving limbs can engage autistic children in a better way. Facial expression of the robots can elicit a greater response than prompting by humans.
C1 [Lee, Jaeryoung; Nagai, Chikara] Nagoya Univ, Grad Sch Engn, Nagoya, Aichi 4648601, Japan.
[Takehashi, Hiroki] Tokyo Future Univ, Tokyo, Japan.
[Obinata, Goro] Nagoya Univ, EcoTopia Sci Inst, Nagoya, Aichi 4648601, Japan.
[Stefanov, Dimitar] Coventry Univ, Fac Engn & Comp, Coventry, W Midlands, England.
RP Lee, J (reprint author), Nagoya Univ, Grad Sch Engn, Nagoya, Aichi 4648601, Japan.
EM lee.jaeryoung@a.mbox.nagoya-u.ac.jp
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
Boccanfuso L, 2010, P 2 INT C SOC ROB IC, P265
Davis K, 2005, P 8 EUR C ADV ASS TE, P353
Duquette A, 2006, P INT C EP ROB MOD C
FERRARA C, 1980, J AUTISM DEV DISORD, V10, P51, DOI 10.1007/BF02408432
Hughes JR, 2008, EPILEPSY BEHAV, V13, P425, DOI 10.1016/j.yebeh.2008.06.015
John N.C., 2002, SOCIAL RESPONSIVENES
Kanner L, 1943, NERV CHILD, V2, P217
Kim AH, 2003, J EARLY INTERVENTION, V25, P189, DOI 10.1177/105381510302500304
Kozima H, 2009, INT J SOC ROBOT, V1, P3, DOI 10.1007/s12369-008-0009-8
Michaud F, 2005, IEEE T SYST MAN CY A, V35, P471, DOI 10.1109/TSMCA.2005.850596
Miyamoto E, 2005, P 5 INT WORKSH EP RO, P145
REIS HT, 1982, J PERS SOC PSYCHOL, V43, P979, DOI 10.1037//0022-3514.43.5.979
Robins B, 2004, DESIGNING A MORE INCLUSIVE WORLD, P225
Robins B, 2006, INTERACT STUD, V7, P479
Robins B, 2010, INT J HUM-COMPUT ST, V68, P873, DOI 10.1016/j.ijhcs.2010.08.001
Robins B., 2009, P 2 INT C ADV COMP H, P205
Schmidt ME, 2008, CHILD DEV, V79, P1137, DOI 10.1111/j.1467-8624.2008.01180.x
WEEKS SJ, 1987, J CHILD PSYCHOL PSYC, V28, P137, DOI 10.1111/j.1469-7610.1987.tb00658.x
Werry I, 2001, LECT NOTES ARTIF INT, V2117, P57
NR 20
TC 1
Z9 1
PU INTECH -OPEN ACCESS PUBLISHER
PI RIJEKA
PA UNIV CAMPUS STEP RI, SLAVKA KRAUTZEKA 83/A, RIJEKA, 51000, CROATIA
SN 1729-8806
EI 1729-8814
J9 INT J ADV ROBOT SYST
JI Int. J. Adv. Robot. Syst.
PD SEP 19
PY 2012
VL 9
AR 72
DI 10.5772/51128
PG 6
WC Robotics
SC Robotics
GA 022EX
UT WOS:000309939500004
ER
PT J
AU Berry-Kravis, EM
Hessl, D
Rathmell, B
Zarevics, P
Cherubini, M
Walton-Bowen, K
Mu, Y
Nguyen, DV
Gonzalez-Heydrich, J
Wang, PP
Carpenter, RL
Bear, MF
Hagerman, RJ
AF Berry-Kravis, Elizabeth M.
Hessl, David
Rathmell, Barbara
Zarevics, Peter
Cherubini, Maryann
Walton-Bowen, Karen
Mu, Yi
Nguyen, Danh V.
Gonzalez-Heydrich, Joseph
Wang, Paul P.
Carpenter, Randall L.
Bear, Mark F.
Hagerman, Randi J.
TI Effects of STX209 (Arbaclofen) on Neurobehavioral Function in Children
and Adults with Fragile X Syndrome: A Randomized, Controlled, Phase 2
Trial
SO SCIENCE TRANSLATIONAL MEDICINE
LA English
DT Article
ID ABERRANT BEHAVIOR CHECKLIST; MOUSE MODEL; PHARMACOLOGICAL RESCUE;
AUTISM; DISORDERS; AMYGDALA; SCALE; IDENTIFICATION; VALIDATION;
PHENOTYPES
AB Research on animal models of fragile X syndrome suggests that STX209, a gamma-aminobutyric acid type B (GABA(B)) agonist, might improve neurobehavioral function in affected patients. We evaluated whether STX209 improves behavioral symptoms of fragile X syndrome in a randomized, double-blind, placebo-controlled crossover study in 63 subjects (55 male), ages 6 to 39 years, with a full mutation in the FMR1 gene (>200 CGG triplet repeats). We found no difference from placebo on the primary endpoint, the Aberrant Behavior Checklist-Irritability (ABC-I) subscale. In the other analyses specified in the protocol, improvement was seen on the visual analog scale ratings of parent-nominated problem behaviors, with positive trends on multiple global measures. Post hoc analysis with the ABC-Social Avoidance scale, a newly validated scale for the assessment of fragile X syndrome, showed a significant beneficial treatment effect in the full study population. A post hoc subgroup of 27 subjects with more severe social impairment showed improvements on the Vineland II-Socialization raw score, on the ABC-Social Avoidance scale, and on all global measures. STX209 was well tolerated, with 8% incidences of sedation and of headache as the most frequent side effects. In this exploratory study, STX209 did not show a benefit on irritability in fragile X syndrome. Nonetheless, our results suggest that GABA(B) agonists have potential to improve social function and behavior in patients with fragile X syndrome.
C1 [Rathmell, Barbara; Zarevics, Peter; Cherubini, Maryann; Walton-Bowen, Karen; Wang, Paul P.; Carpenter, Randall L.] Seaside Therapeut Inc, Cambridge, MA 02139 USA.
[Berry-Kravis, Elizabeth M.] Rush Univ, Med Ctr, Dept Pediat, Chicago, IL 60612 USA.
[Berry-Kravis, Elizabeth M.] Rush Univ, Med Ctr, Dept Neurol Sci, Chicago, IL 60612 USA.
[Berry-Kravis, Elizabeth M.] Rush Univ, Med Ctr, Dept Biochem, Chicago, IL 60612 USA.
[Hessl, David; Hagerman, Randi J.] Univ Calif Davis, Med Ctr, Med Invest Neurodev Disorders MIND Inst, Sacramento, CA 95817 USA.
[Hessl, David; Hagerman, Randi J.] Univ Calif Davis, Med Ctr, Dept Psychiat & Behav Sci, Sacramento, CA 95817 USA.
[Mu, Yi; Nguyen, Danh V.] Univ Calif Davis, Dept Publ Hlth Sci, Div Biostat, Sacramento, CA 95817 USA.
[Gonzalez-Heydrich, Joseph] Childrens Hosp, Dept Psychiat, Boston, MA 02115 USA.
[Bear, Mark F.] MIT, Dept Brain & Cognit Sci, Cambridge, MA 02139 USA.
RP Wang, PP (reprint author), Seaside Therapeut Inc, Cambridge, MA 02139 USA.
EM pwang@seasidetherapeutics.com
FU Seaside Therapeutics Inc.
FX This study was sponsored by Seaside Therapeutics Inc.
CR AMAN MG, 1985, AM J MENT DEF, V89, P485
Bear MF, 2004, TRENDS NEUROSCI, V27, P370, DOI 10.1016/j.tins.2004.04.009
Berry-Kravis E, 2004, MENT RETARD DEV D R, V10, P42, DOI 10.1002/mrdd.20007
Bradley C, 1937, AM J PSYCHIAT, V94, P577
Budimirovic DB, 2006, AM J MED GENET A, V140A, P1814, DOI 10.1002/ajmg.a.31405
Chang S, 2008, NAT CHEM BIOL, V4, P256, DOI 10.1038/nchembio.78
Constantino JN, 2003, J AUTISM DEV DISORD, V33, P427, DOI 10.1023/A:1025014929212
Cordeiro L, 2011, J NEURODEV DISORD, V3, P57, DOI 10.1007/s11689-010-9067-y
de Vrij FMS, 2008, NEUROBIOL DIS, V31, P127, DOI 10.1016/j.nbd.2008.04.002
D'Hulst C, 2007, TRENDS NEUROSCI, V30, P425, DOI 10.1016/j.tins.2007.06.003
Dolen G, 2007, NEURON, V56, P955, DOI 10.1016/j.neuron.2007.12.001
DuPaul G. J, 1998, ADHD RATING SCALE
Ehninger D, 2011, TRENDS MOL MED, V17, P78, DOI 10.1016/j.molmed.2010.10.002
Farzin F, 2009, J AUTISM DEV DISORD, V39, P946, DOI 10.1007/s10803-009-0744-1
Gatto Cheryl L, 2010, Front Synaptic Neurosci, V2, P4, DOI 10.3389/fnsyn.2010.00004
Hagerman RJ, 2009, PEDIATRICS, V123, P378, DOI 10.1542/peds.2008-0317
Henderson C, 2012, SCI TRANSL MED, V4, DOI 10.1126/scitranslmed.3004218
Isaacson JS, 1997, NEURON, V18, P143, DOI 10.1016/S0896-6273(01)80053-2
Jacquemont S, 2011, SCI TRANSL MED, V3, DOI 10.1126/scitranslmed.3001708
Krueger DD, 2011, ANNU REV MED, V62, P411, DOI 10.1146/annurev-med-061109-134644
Lam KSL, 2007, J AUTISM DEV DISORD, V37, P855, DOI 10.1007/s10803-006-0213-z
McBride SMJ, 2005, NEURON, V45, P753, DOI 10.1016/j.neuron.2005.01.038
Mutschler E., 1990, CHIRALITY BIOL ACTIV, P283
Olmos-Serrano JL, 2010, J NEUROSCI, V30, P9929, DOI 10.1523/JNEUROSCI.1714-10.2010
Olmos-Serrano JL, 2011, DEV NEUROSCI-BASEL, V33, P365, DOI 10.1159/000329424
Owen R, 2009, PEDIATRICS, V124, P1533, DOI 10.1542/peds.2008-3782
McCracken JT, 2002, NEW ENGL J MED, V347, P314, DOI 10.1056/NEJMoa013171
Roberts JE, 2007, J AUTISM DEV DISORD, V37, P1748, DOI 10.1007/s10803-006-0305-9
Sansone SM, 2012, J AUTISM DEV DISORD, V42, P1377, DOI 10.1007/s10803-011-1370-2
Sparrow SS, 2005, VINELAND ADAPTIVE BE
Sukhodolsky DG, 2008, J ABNORM CHILD PSYCH, V36, P117, DOI 10.1007/s10802-007-9165-9
Suvrathan A, 2010, P NATL ACAD SCI USA, V107, P11591, DOI 10.1073/pnas.1002262107
VERKERK AJMH, 1991, CELL, V65, P905, DOI 10.1016/0092-8674(91)90397-H
Wang LW, 2010, NEUROTHERAPEUTICS, V7, P264, DOI 10.1016/j.nurt.2010.05.005
Watson C, 2008, ARCH GEN PSYCHIAT, V65, P1315, DOI 10.1001/archpsyc.65.11.1315
Wetmore DZ, 2010, J DEV BEHAV PEDIATR, V31, P564, DOI 10.1097/DBP.0b013e3181ee3833
Yan QJ, 2005, NEUROPHARMACOLOGY, V49, P1053, DOI 10.1016/j.neuropharm.2005.06.004
NR 37
TC 47
Z9 51
PU AMER ASSOC ADVANCEMENT SCIENCE
PI WASHINGTON
PA 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA
SN 1946-6234
J9 SCI TRANSL MED
JI Sci. Transl. Med.
PD SEP 19
PY 2012
VL 4
IS 152
AR 152ra127
DI 10.1126/scitranslmed.3004214
PG 7
WC Cell Biology; Medicine, Research & Experimental
SC Cell Biology; Research & Experimental Medicine
GA 010RX
UT WOS:000309112900003
PM 22993294
ER
PT J
AU Henderson, C
Wijetunge, L
Kinoshita, MN
Shumway, M
Hammond, RS
Postma, FR
Brynczka, C
Rush, R
Thomas, A
Paylor, R
Warren, ST
Vanderklish, PW
Kind, PC
Carpenter, RL
Bear, MF
Healy, AM
AF Henderson, Christina
Wijetunge, Lasani
Kinoshita, Mika Nakamoto
Shumway, Matthew
Hammond, Rebecca S.
Postma, Friso R.
Brynczka, Christopher
Rush, Roger
Thomas, Alexia
Paylor, Richard
Warren, Stephen T.
Vanderklish, Peter W.
Kind, Peter C.
Carpenter, Randall L.
Bear, Mark F.
Healy, Aileen M.
TI Reversal of Disease-Related Pathologies in the Fragile X Mouse Model by
Selective Activation of GABA(B) Receptors with Arbaclofen
SO SCIENCE TRANSLATIONAL MEDICINE
LA English
DT Article
ID MENTAL-RETARDATION PROTEIN; METABOTROPIC GLUTAMATE RECEPTORS; FMR1
KNOCKOUT MICE; PRIMARY SOMATOSENSORY CORTEX; LONG-TERM POTENTIATION;
HIPPOCAMPAL-NEURONS; DENDRITIC SPINES; STARTLE RESPONSE; GENETIC
REDUCTION; AUTISTIC BEHAVIOR
AB Fragile X syndrome (FXS), the most common inherited cause of intellectual disability and autism, results from the transcriptional silencing of FMR1 and loss of the mRNA translational repressor protein fragile X mental retardation protein (FMRP). Patients with FXS exhibit changes in neuronal dendritic spine morphology, a pathology associated with altered synaptic function. Studies in the mouse model of fragile X have shown that loss of FMRP causes excessive synaptic protein synthesis, which results in synaptic dysfunction and altered spine morphology. We tested whether the pharmacologic activation of the gamma-aminobutyric acid type B (GABA(B)) receptor could correct or reverse these phenotypes in Fmr1-knockout mice. Basal protein synthesis, which is elevated in the hippocampus of Fmr1-knockout mice, was corrected by the in vitro application of the selective GABA(B) receptor agonist STX209 (arbaclofen, R-baclofen). STX209 also reduced to wild-type values the elevated AMPA receptor internalization in Fmr1-knockout cultured neurons, a known functional consequence of increased protein synthesis. Acute administration of STX209 in vivo, at doses that modify behavior, decreased mRNA translation in the cortex of Fmr1-knockout mice. Finally, the chronic administration of STX209 in juvenile mice corrected the increased spine density in Fmr1-knockout mice without affecting spine density in wild-type mice. Thus, activation of the GABA(B) receptor with STX209 corrected synaptic abnormalities considered central to fragile X pathophysiology, a finding that suggests that STX209 may be a potentially effective therapy to treat the core symptoms of FXS.
C1 [Henderson, Christina; Shumway, Matthew; Hammond, Rebecca S.; Postma, Friso R.; Brynczka, Christopher; Rush, Roger; Carpenter, Randall L.; Healy, Aileen M.] Seaside Therapeut Inc, Cambridge, MA 02139 USA.
[Wijetunge, Lasani; Kind, Peter C.] Univ Edinburgh, Patrick Wild Ctr, Edinburgh EH8 9XD, Midlothian, Scotland.
[Kinoshita, Mika Nakamoto; Warren, Stephen T.] Emory Univ, Dept Human Genet, Atlanta, GA 30322 USA.
[Thomas, Alexia; Paylor, Richard] Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA.
[Vanderklish, Peter W.] Scripps Res Inst, Dept Neurobiol, La Jolla, CA 92037 USA.
[Bear, Mark F.] MIT, Dept Brain & Cognit Sci, Cambridge, MA 02139 USA.
RP Healy, AM (reprint author), Seaside Therapeut Inc, Cambridge, MA 02139 USA.
EM ahealy@seasidetherapeutics.com
FU Seaside Therapeutics; NIH [HD020521, HD24064]; Medical Research Council
[G0601584]
FX This work was supported in part by Seaside Therapeutics, NIH grants
HD020521 and HD24064 to S. T. W., and Medical Research Council grant
G0601584 to P.C.K.
CR Adusei DC, 2010, NEUROPHARMACOLOGY, V59, P167, DOI 10.1016/j.neuropharm.2010.05.002
American Psychiatric Association, 2000, DIAGN CRIT DSM 4 TR
Aschrafi A, 2005, P NATL ACAD SCI USA, V102, P2180, DOI 10.1073/pnas.0409803102
Auerbach BD, 2011, NATURE, V480, P63, DOI 10.1038/nature10658
Auerbach BD, 2010, J NEUROPHYSIOL, V104, P1047, DOI 10.1152/jn.00449.2010
Bailey DB, 2009, PEDIATRICS, V124, P527, DOI 10.1542/peds.2008-2992
Bear MF, 2004, TRENDS NEUROSCI, V27, P370, DOI 10.1016/j.tins.2004.04.009
Berry-Kravis EM, 2012, SCI TRANSL MED, V4, DOI 10.1126/scitranslmed.3004214
Bhakar AL, 2012, ANNU REV NEUROSCI, V35, P417, DOI 10.1146/annurev-neuro-060909-153138
Bilousova TV, 2009, J MED GENET, V46, P94, DOI 10.1136/jmg.2008.061796
Bosch M, 2012, CURR OPIN NEUROBIOL, V22, P383, DOI 10.1016/j.conb.2011.09.002
Chen L, 2001, NEUROSCIENCE, V103, P1043, DOI 10.1016/S0306-4522(01)00036-7
Chuang SC, 2005, J NEUROSCI, V25, P8048, DOI 10.1523/JNEUROSCI.1777-05.2005
BAKKER CE, 1994, CELL, V78, P23
Cruz-Martin A, 2010, J NEUROSCI, V30, P7793, DOI 10.1523/JNEUROSCI.0577-10.2010
Darnell JC, 2011, CELL, V146, P247, DOI 10.1016/j.cell.2011.06.013
D'Hulst C, 2006, BRAIN RES, V1121, P238, DOI 10.1016/j.brainres.2006.08.115
Dolen G, 2008, J PHYSIOL-LONDON, V586, P1503, DOI 10.1113/jphysiol.2008.150722
Dolen G, 2007, NEURON, V56, P955, DOI 10.1016/j.neuron.2007.12.001
Eberhart DE, 1996, HUM MOL GENET, V5, P1083, DOI 10.1093/hmg/5.8.1083
El Idrissi A, 2005, NEUROSCI LETT, V377, P141, DOI 10.1016/j.neulet.2004.11.087
Farkas Sandor, 2005, Journal of Pharmacological and Toxicological Methods, V52, P264, DOI 10.1016/j.vascn.2004.11.005
Fridell RA, 1996, EMBO J, V15, P5408
Galvez R, 2005, AM J MED GENET A, V135A, P155, DOI 10.1002/ajmg.a.30709
Garber KB, 2008, EUR J HUM GENET, V16, P666, DOI 10.1038/ejhg.2008.61
Garey LJ, 1998, J NEUROL NEUROSUR PS, V65, P446, DOI 10.1136/jnnp.65.4.446
GIANUTSOS G, 1978, J PHARMACOL EXP THER, V207, P859
Gibson JR, 2008, J NEUROPHYSIOL, V100, P2615, DOI 10.1152/jn.90752.2008
Greenough WT, 2001, P NATL ACAD SCI USA, V98, P7101, DOI 10.1073/pnas.141145998
Gross C, 2010, J NEUROSCI, V30, P10624, DOI 10.1523/JNEUROSCI.0402-10.2010
Hagerman R., 2010, MOL AUTISM, V1, P1, DOI DOI 10.1186/2040-2392-1-12
Hagerman RJ, 2009, PEDIATRICS, V123, P378, DOI 10.1542/peds.2008-0317
Harlow EG, 2010, NEURON, V65, P385, DOI 10.1016/j.neuron.2010.01.024
HINTON VJ, 1991, AM J MED GENET, V41, P289, DOI 10.1002/ajmg.1320410306
HOLLINGSWORTH EB, 1985, J NEUROSCI, V5, P2240
Hou LF, 2006, NEURON, V51, P441, DOI 10.1016/j.neuron.2006.07.005
Huber KM, 2002, P NATL ACAD SCI USA, V99, P7746, DOI 10.1073/pnas.122205699
HUTTENLOCHER PR, 1990, NEUROPSYCHOLOGIA, V28, P517, DOI 10.1016/0028-3932(90)90031-I
Irwin SA, 2001, AM J MED GENET, V98, P161, DOI 10.1002/1096-8628(20010115)98:2<161::AID-AJMG1025>3.0.CO;2-B
Irwin SA, 2000, CEREB CORTEX, V10, P1038, DOI 10.1093/cercor/10.10.1038
Isaacson JS, 1997, NEURON, V18, P143, DOI 10.1016/S0896-6273(01)80053-2
Jacquemont S, 2011, SCI TRANSL MED, V3, DOI 10.1126/scitranslmed.3001708
Kaech S, 2006, NAT PROTOC, V1, P2406, DOI 10.1038/nprot.2006.356
Kanai Y, 2004, NEURON, V43, P513, DOI 10.1016/j.neuron.2004.07.022
Kao DI, 2010, P NATL ACAD SCI USA, V107, P15601, DOI 10.1073/pnas.1010564107
Karl T, 2003, EXP TOXICOL PATHOL, V55, P69, DOI 10.1078/0940-2993-00301
Khandjian EW, 2004, P NATL ACAD SCI USA, V101, P13357, DOI 10.1073/pnas.0405398101
Kim M, 2009, MOL CELL BIOL, V29, P214, DOI 10.1128/MCB.01377-08
Koekkoek SKE, 2005, NEURON, V47, P339, DOI 10.1016/j.neuron.2005.07.005
Konur S, 2004, J NEUROBIOL, V59, P236, DOI 10.1002/neu.10306
Krichevsky AM, 2001, NEURON, V32, P683, DOI 10.1016/S0896-6273(01)00508-6
Krueger DD, 2011, P NATL ACAD SCI USA, V108, P2587, DOI 10.1073/pnas.1013855108
Krueger DD, 2011, ANNU REV MED, V62, P411, DOI 10.1146/annurev-med-061109-134644
Li MS, 2010, BRAIN RES BULL, V81, P107, DOI 10.1016/j.brainresbull.2009.08.028
Liu ZH, 2009, NEUROSCI LETT, V454, P62, DOI 10.1016/j.neulet.2009.02.066
Liu-Yesucevitz L, 2011, J NEUROSCI, V31, P16086, DOI 10.1523/JNEUROSCI.4105-11.2011
Luscher C, 1997, NEURON, V19, P687, DOI 10.1016/S0896-6273(00)80381-5
Malenka RC, 2004, NEURON, V44, P5, DOI 10.1016/j.neuron.2004.09.012
Michalon A, 2012, NEURON, V74, P49, DOI 10.1016/j.neuron.2012.03.009
Mineur YS, 2002, HIPPOCAMPUS, V12, P39, DOI 10.1002/hipo.10005
Nakamoto M, 2007, P NATL ACAD SCI USA, V104, P15537, DOI 10.1073/pnas.0707484104
Nielsen DM, 2002, BRAIN RES, V927, P8, DOI 10.1016/S0006-8993(01)03309-1
Nimchinsky EA, 2001, J NEUROSCI, V21, P5139
Nosyreva ED, 2006, J NEUROPHYSIOL, V95, P3291, DOI 10.1152/jn.01316.2005
Olmos-Serrano JL, 2010, J NEUROSCI, V30, P9929, DOI 10.1523/JNEUROSCI.1714-10.2010
Osterweil EK, 2010, J NEUROSCI, V30, P15616, DOI 10.1523/JNEUROSCI.3888-10.2010
Pacey LKK, 2011, J PHARMACOL EXP THER, V338, P897, DOI 10.1124/jpet.111.183327
Pan F, 2010, P NATL ACAD SCI USA, V107, P17768, DOI 10.1073/pnas.1012496107
Penagarikano O, 2007, ANNU REV GENOM HUM G, V8, P109, DOI 10.1146/annurev.genom.8.080706.092249
Pfeiffer BE, 2009, NEUROSCIENTIST, V15, P549, DOI 10.1177/1073858409333075
Portera-Cailliau C, 2012, NEUROSCIENTIST, V18, P28, DOI 10.1177/1073858410395322
Qin M, 2005, J NEUROSCI, V25, P5087, DOI 10.1523/JNEUROSCI.0093-05.2005
Reiss AL, 2007, CHILD ADOL PSYCH CL, V16, P663, DOI 10.1016/j.chc.2007.03.001
REISS AL, 1992, AM J MED GENET, V43, P35, DOI 10.1002/ajmg.1320430106
Restivo L, 2005, P NATL ACAD SCI USA, V102, P11557, DOI 10.1073/pnas.0504984102
Roberts JE, 2007, J AUTISM DEV DISORD, V37, P1748, DOI 10.1007/s10803-006-0305-9
RUDELLI RD, 1985, ACTA NEUROPATHOL, V67, P289
Selby L, 2007, NEUROSCI LETT, V412, P227, DOI 10.1016/j.neulet.2006.11.062
Sohn JW, 2007, J PHYSIOL-LONDON, V580, P411, DOI 10.1113/jphysiol.2006.125914
Spencer CA, 2008, BEHAV NEUROSCI, V122, P710, DOI 10.1037/0735-7044.122.3.710
Su T, 2011, PSYCHOPHARMACOLOGY, V215, P291, DOI 10.1007/s00213-010-2130-2
SUETSUGU M, 1980, ACTA NEUROPATHOL, V50, P207
Thomas A, 2009, PSYCHOPHARMACOLOGY, V204, P361, DOI 10.1007/s00213-009-1466-y
Thomas AM, 2012, PSYCHOPHARMACOLOGY, V219, P47, DOI 10.1007/s00213-011-2375-4
Thomas AM, 2011, BEHAV BRAIN RES, V223, P310, DOI 10.1016/j.bbr.2011.04.049
Till SM, 2012, HUM MOL GENET, V21, P2143, DOI 10.1093/hmg/dds030
Veeraragavan S, 2011, PSYCHOPHARMACOLOGY, V217, P143, DOI 10.1007/s00213-011-2276-6
Veeraragavan S, 2011, BEHAV NEUROSCI, V125, P783, DOI 10.1037/a0025202
Veeraragavan S, 2012, BEHAV BRAIN RES, V228, P1, DOI 10.1016/j.bbr.2011.11.018
VERKERK AJMH, 1991, CELL, V65, P905, DOI 10.1016/0092-8674(91)90397-H
Watson C, 2008, ARCH GEN PSYCHIAT, V65, P1315, DOI 10.1001/archpsyc.65.11.1315
Weiler IJ, 1997, P NATL ACAD SCI USA, V94, P5395, DOI 10.1073/pnas.94.10.5395
WEILER IJ, 1993, P NATL ACAD SCI USA, V90, P7168, DOI 10.1073/pnas.90.15.7168
Weiler IJ, 2004, P NATL ACAD SCI USA, V101, P17504, DOI 10.1073/pnas.0407533101
Wijetunge LS, 2008, J NEUROSCI, V28, P13028, DOI 10.1523/JNEUROSCI.2600-08.2008
Williams JM, 2007, J NEUROSCI, V27, P14171, DOI 10.1523/JNEUROSCI.2348-07.2007
WISNIEWSKI KE, 1991, AM J MED GENET, V38, P476, DOI 10.1002/ajmg.1320380267
Yan QJ, 2005, NEUROPHARMACOLOGY, V49, P1053, DOI 10.1016/j.neuropharm.2005.06.004
Yan QJ, 2004, GENES BRAIN BEHAV, V3, P337, DOI 10.1111/j.1601-183X.2004.00087.x
Yun SW, 2006, BRAIN RES, V1110, P159, DOI 10.1016/j.brainres.2006.06.086
NR 100
TC 40
Z9 41
PU AMER ASSOC ADVANCEMENT SCIENCE
PI WASHINGTON
PA 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA
SN 1946-6234
J9 SCI TRANSL MED
JI Sci. Transl. Med.
PD SEP 19
PY 2012
VL 4
IS 152
AR 152ra128
DI 10.1126/scitranslmed.3004218
PG 11
WC Cell Biology; Medicine, Research & Experimental
SC Cell Biology; Research & Experimental Medicine
GA 010RX
UT WOS:000309112900004
PM 22993295
ER
PT J
AU Hughes, V
Sheng, M
Zoghbi, H
AF Hughes, Virginia
Sheng, Morgan
Zoghbi, Huda
TI Childhood Disorders of the Synapse: Challenges and Opportunities
SO SCIENCE TRANSLATIONAL MEDICINE
LA English
DT Article
ID DE-NOVO MUTATIONS; AUTISM SPECTRUM DISORDERS; RETT-SYNDROME; MOUSE
MODEL; LEARNING-DEFICITS; FRAGILE-X; REVERSAL; GENE; MICE; MECP2
AB Earlier this year, a diverse group convened at the Jan and Dan Duncan Neurological Research Institute and Baylor College of Medicine to discuss research on neurodevelop-mental disorders involving the synapse. Participants discussed current challenges in the field and made recommendations for future research directions.
C1 [Sheng, Morgan] Genentech Inc, Dept Neurosci, San Francisco, CA 94080 USA.
[Zoghbi, Huda] Texas Childrens Hosp, Baylor Coll Med, Howard Hughes Med Inst, Dept Pediat, Houston, TX 77030 USA.
[Zoghbi, Huda] Texas Childrens Hosp, Baylor Coll Med, Howard Hughes Med Inst, Dept Neurol, Houston, TX 77030 USA.
[Zoghbi, Huda] Texas Childrens Hosp, Baylor Coll Med, Howard Hughes Med Inst, Dept Neurosci, Houston, TX 77030 USA.
[Zoghbi, Huda] Texas Childrens Hosp, Baylor Coll Med, Howard Hughes Med Inst, Dept Mol & Human Genet, Houston, TX 77030 USA.
[Zoghbi, Huda] Texas Childrens Hosp, Jan & Dan Duncan Neurol Res Inst, Houston, TX 77030 USA.
EM virginia.hughes@gmail.com; hzoghbi@bcm.edu
FU Texas Children's Hospital; Baylor College of Medicine; Perkins+Will;
Angelman Syndrome Foundation; Autism Speaks; Genentech; GlaxoSmithKline;
International Rett Syndrome Foundation; Novartis; Phelan-McDermid
Syndrome Foundation; Rett Syndrome Research Trust; Simons Foundation
Autism Research Initiative; VWR; Zeiss
FX This conference could not have happened without the help of our
sponsors. We sincerely thank the following research institutes,
foundations, and corporations that supported the 2012 Disorders of
Synaptic Dysfunction Symposium: Texas Children's Hospital, Baylor
College of Medicine, Perkins+Will, Angelman Syndrome Foundation, Autism
Speaks, Genentech, GlaxoSmithKline, International Rett Syndrome
Foundation, Novartis, Phelan-McDermid Syndrome Foundation, Rett Syndrome
Research Trust, Simons Foundation Autism Research Initiative, VWR, and
Zeiss. We are also grateful to several Houston families of children with
synaptic disorders who offered a patient's perspective to the meeting's
scientific attendees.
CR Auerbach BD, 2011, NATURE, V480, P63, DOI 10.1038/nature10658
Berkel S, 2010, NAT GENET, V42, P489, DOI 10.1038/ng.589
Berry-Kravis EM, 2012, SCI TRANSL MED, V4, DOI 10.1126/scitranslmed.3004214
Chao HT, 2010, NATURE, V468, P263, DOI 10.1038/nature09582
Costa RM, 2002, NATURE, V415, P526, DOI 10.1038/nature711
Derecki NC, 2012, NATURE, V484, P105, DOI 10.1038/nature10907
Dolen G, 2007, NEURON, V56, P955, DOI 10.1016/j.neuron.2007.12.001
Durand CM, 2007, NAT GENET, V39, P25, DOI 10.1038/ng1933
Ehninger D, 2008, NAT MED, V14, P843, DOI 10.1038/nm1788
Guy J, 2007, SCIENCE, V315, P1143, DOI 10.1126/science.1138389
Henderson C, 2012, SCI TRANSL MED, V4, DOI 10.1126/scitranslmed.3004218
Huang HS, 2012, NATURE, V481, P185, DOI 10.1038/nature10726
Iossifov I, 2012, NEURON, V74, P285, DOI 10.1016/j.neuron.2012.04.009
Jamain S, 2003, NAT GENET, V34, P27, DOI 10.1038/ng1136
McGraw CM, 2011, SCIENCE, V333, P186, DOI 10.1126/science.1206593
Michalon A, 2012, NEURON, V74, P49, DOI 10.1016/j.neuron.2012.03.009
Neale BM, 2012, NATURE, V485, P242, DOI 10.1038/nature11011
O'Roak BJ, 2012, NATURE, V485, P246, DOI 10.1038/nature10989
Robinson L, 2012, BRAIN, V135, P2699, DOI 10.1093/brain/aws096
Rogers SJ, 2008, J CLIN CHILD ADOLESC, V37, P8, DOI 10.1080/15374410701817808
Sanders SJ, 2012, NATURE, V485, P237, DOI 10.1038/nature10945
Sarewitz D, 2012, NATURE, V485, P149, DOI 10.1038/485149a
Silverman JL, 2012, SCI TRANSL MED, V4, DOI 10.1126/scitranslmed.3003501
Spencer CM, 2011, AUTISM RES, V4, P40, DOI 10.1002/aur.168
Tropea D, 2009, P NATL ACAD SCI USA, V106, P2029, DOI 10.1073/pnas.0812394106
NR 25
TC 0
Z9 0
PU AMER ASSOC ADVANCEMENT SCIENCE
PI WASHINGTON
PA 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA
SN 1946-6234
J9 SCI TRANSL MED
JI Sci. Transl. Med.
PD SEP 19
PY 2012
VL 4
IS 152
AR 152ps17
DI 10.1126/scitranslmed.3004356
PG 6
WC Cell Biology; Medicine, Research & Experimental
SC Cell Biology; Research & Experimental Medicine
GA 010RX
UT WOS:000309112900002
PM 22993293
ER
PT J
AU Carmona-Mora, P
Canales, CP
Cao, L
Perez, IC
Srivastava, AK
Young, JI
Walz, K
AF Carmona-Mora, Paulina
Canales, Cesar P.
Cao, Lei
Perez, Irene C.
Srivastava, Anand K.
Young, Juan I.
Walz, Katherina
TI RAI1 Transcription Factor Activity Is Impaired in Mutants Associated
with Smith-Magenis Syndrome
SO PLOS ONE
LA English
DT Article
ID ACID-INDUCED 1; 17P11.2 DELETIONS; GENE; MUTATIONS; PHENOTYPE; PHD;
AUTISM; DUP(17)(P11.2P11.2); IDENTIFICATION; SCHIZOPHRENIA
AB Smith-Magenis Syndrome (SMS) is a complex genomic disorder mostly caused by the haploinsufficiency of the Retinoic Acid Induced 1 gene (RAI1), located in the chromosomal region 17p11.2. In a subset of SMS patients, heterozygous mutations in RAI1 are found. Here we investigate the molecular properties of these mutated forms and their relationship with the resulting phenotype. We compared the clinical phenotype of SMS patients carrying a mutation in RAI1 coding region either in the N-terminal or the C-terminal half of the protein and no significant differences were found. In order to study the molecular mechanism related to these two groups of RAI1 mutations first we analyzed those mutations that result in the truncated protein corresponding to the N-terminal half of RAI1 finding that they have cytoplasmic localization (in contrast to full length RAI1) and no ability to activate the transcription through an endogenous target: the BDNF enhancer. Similar results were found in lymphoblastoid cells derived from a SMS patient carrying RAI1 c.3103insC, where both mutant and wild type products of RAI1 were detected. The wild type form of RAI1 was found in the chromatin bound and nuclear matrix subcellular fractions while the mutant product was mainly cytoplasmic. In addition, missense mutations at the C-terminal half of RAI1 presented a correct nuclear localization but no activation of the endogenous target. Our results showed for the first time a correlation between RAI1 mutations and abnormal protein function plus they suggest that a reduction of total RAI1 transcription factor activity is at the heart of the SMS clinical presentation.
C1 [Carmona-Mora, Paulina; Canales, Cesar P.; Perez, Irene C.; Young, Juan I.; Walz, Katherina] Univ Miami, Miller Sch Med, John P Hussman Inst Human Genom, Miami, FL 33136 USA.
[Cao, Lei; Young, Juan I.; Walz, Katherina] Univ Miami, Miller Sch Med, Dr John T Macdonald Fdn, Dept Human Genet, Miami, FL 33136 USA.
[Srivastava, Anand K.] Greenwood Genet Ctr, JC Self Res Inst Human Genet, Greenwood, SC 29646 USA.
[Srivastava, Anand K.] Clemson Univ, Dept Biochem & Genet, Clemson, SC USA.
[Walz, Katherina] Univ Miami, Miller Sch Med, Dept Med, Miami, FL 33136 USA.
RP Walz, K (reprint author), Univ Miami, Miller Sch Med, John P Hussman Inst Human Genom, Miami, FL 33136 USA.
EM kwalz@med.miami.edu
FU Le Jerome Foundation
FX This work was supported in part by Le Jerome Foundation (KW). The funder
had no role in study design, data collection and analysis, decision to
publish, or preparation of the manuscript. No additional external
funding was received for this study.
CR Bi W, 2006, AM J MED GENET A, V140A, P2454, DOI 10.1002/ajmg.a.31510
Bi WM, 2004, HUM GENET, V115, P515, DOI 10.1007/s00439-004-1187-6
Bienz M, 2006, TRENDS BIOCHEM SCI, V31, P35, DOI 10.1016/j.tibs.2005.11.001
Burns B, 2010, HUM MOL GENET, V19, P4026, DOI 10.1093/hmg/ddq317
Carmona-Mora P, 2010, BMC MOL BIOL, V11, DOI 10.1186/1471-2199-11-63
Carmona-Mora P, 2010, CURR GENOMICS, V11, P607, DOI 10.2174/138920210793360952
Darvekar S, 2012, BIOCHEM J, V442, P65, DOI 10.1042/BJ20111230
Edelman EA, 2007, CLIN GENET, V71, P540, DOI 10.1111/j.1399-0004.2007.00815.x
Gerhard DS, 2004, GENOME RES, V14, P2121
Girirajan S, 2006, GENET MED, V8, P417, DOI 10.1097/01.gim.0000228215.32110.89
Girirajan S, 2009, CLIN GENET, V75, P364, DOI 10.1111/j.1399-0004.2008.01135.x
Girirajan S, 2005, J MED GENET, V42, P820, DOI 10.1136/jmg.2005.031211
Greenberg F, 1996, AM J MED GENET, V62, P247, DOI 10.1002/(SICI)1096-8628(19960329)62:3<247::AID-AJMG9>3.3.CO;2-9
Gropman AL, 2007, CURR OPIN NEUROL, V20, P125, DOI 10.1097/WCO.0b013e3280895dba
Hayes S, 2000, HUM MOL GENET, V9, P1753, DOI 10.1093/hmg/9.12.1753
HE DC, 1990, J CELL BIOL, V110, P569, DOI 10.1083/jcb.110.3.569
Joober R, 1999, AM J MED GENET, V88, P694, DOI 10.1002/(SICI)1096-8628(19991215)88:6<694::AID-AJMG20>3.0.CO;2-I
Juyal RC, 1996, AM J HUM GENET, V58, P998
Laje G, 2010, AM J MED GENET C, V154C, P456, DOI 10.1002/ajmg.c.30275
Mellor J, 2006, CELL, V126, P22, DOI 10.1016/j.cell.2006.06.028
Nagase T, 2001, DNA RES, V8, P85, DOI 10.1093/dnares/8.2.85
Peng J, 2008, TRENDS BIOCHEM SCI, V33, P191, DOI 10.1016/j.tibs.2008.02.003
Potocki L, 2007, AM J HUM GENET, V80, P633, DOI 10.1086/512864
Potocki L, 2003, GENET MED, V5, P430, DOI 10.1097/01.GIM.0000095625.14160.AB
Seranski P, 2001, GENE, V270, P69, DOI 10.1016/S0378-1119(01)00415-2
SILVER PA, 1984, P NATL ACAD SCI-BIOL, V81, P5951, DOI 10.1073/pnas.81.19.5951
Slager RE, 2003, NAT GENET, V33, P466, DOI 10.1038/ng1126
Sutherland HGE, 2001, HUM MOL GENET, V10, P1995, DOI 10.1093/hmg/10.18.1995
Toulouse A, 2003, GENOMICS, V82, P162, DOI 10.1016/S0888-7543(03)00101-0
Truong HT, 2010, BMC MED GENET, V11, DOI 10.1186/1471-2350-11-142
van der Zwaag B, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0005324
Vieira GH, 2012, EUR J HUM GENET, V20, P148, DOI 10.1038/ejhg.2011.167
Vilboux T, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0022861
Vlangos CN, 2003, MOL GENET METAB, V79, P134, DOI 10.1016/S1096-7192(03)00048-9
Walz K, 2006, J CLIN INVEST, V116, P3035, DOI 10.1172/JCI28953
Zhang F, 2010, AM J HUM GENET, V86, P462, DOI 10.1016/j.ajhg.2010.02.001
NR 36
TC 6
Z9 6
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD SEP 18
PY 2012
VL 7
IS 9
AR e45155
DI 10.1371/journal.pone.0045155
PG 9
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 040HS
UT WOS:000311313900086
PM 23028815
ER
PT J
AU Rasmussen, TA
Jorgensen, MRS
Bjerrum, S
Jensen-Fangel, S
Stovring, H
Ostergaard, L
Sogaard, OS
AF Rasmussen, Thomas A.
Jorgensen, Martin R. S.
Bjerrum, Stephanie
Jensen-Fangel, Soren
Stovring, Henrik
Ostergaard, Lars
Sogaard, Ole S.
TI Use of population based background rates of disease to assess vaccine
safety in childhood and mass immunisation in Denmark: nationwide
population based cohort study
SO BRITISH MEDICAL JOURNAL
LA English
DT Article
ID GUILLAIN-BARRE-SYNDROME; INFLUENZA-A H1N1; RUBELLA VACCINATION;
TRANSVERSE MYELITIS; MULTIPLE-SCLEROSIS; FEBRILE SEIZURES; MMR
VACCINATION; ADVERSE EVENTS; AUTISM; MEASLES
AB Objectives To predict the number of selected outcomes temporally associated but not caused by vaccination, to aid causality assessment of adverse events arising after mass immunisation in a paediatric population.
Design Nationwide population based cohort study.
Setting Denmark.
Participants All liveborn infants delivered after 1 January 1980. Study population was followed from date of birth until hospital admission for selected outcome diagnoses, death, first emigration, age 18 years, or 31 December 2009. The study population was subject to vaccines used in standard childhood immunisation in Denmark, with 82-93% vaccine coverage.
Main outcome measures Incidence of acute infectious and post-infectious polyneuritis (Guillain-Barre syndrome), acute transverse myelitis, optic polyneuritis, facial nerve palsy, anaphylactic shock, seizure, multiple sclerosis, autoimmune thrombocytopenia, type 1 diabetes mellitus, juvenile and rheumatoid arthritis, narcolepsy, and death of unknown cause stratified by sex, age, and season. We predicted the number of events for a hypothetical vaccine cohort of 1 000 000 people for follow-up periods of up to 182 days.
Results The study included 2 300 227 liveborn infants, yielding 37 262 404 person years of follow-up; median follow-up was 16.8 person years. Incidence of outcome diagnoses spanned from 0.32 per 100 000 patient years for autoimmune thrombocytopenia to 189.82 per 100 000 patient years for seizure. Seasonal differences were most pronounced for anaphylactic shock, seizure, and multiple sclerosis. Even for rare outcomes, numerous events were predicted in the hypothetical vaccine cohort. We predicted that 20 cases of type 1 diabetes mellitus, 19 of juvenile or rheumatoid arthritis, eight of facial nerve palsy, and five of multiple sclerosis per 1 000 000 children would occur within 42 days after vaccination.
Conclusions Incorporating exact background rates of disease based on age, sex, and seasonal distribution could strengthen vaccine safety assessment, and provides an evidence based focus for discussing the incremental risk of newly introduced vaccines.
C1 [Rasmussen, Thomas A.; Jensen-Fangel, Soren; Ostergaard, Lars; Sogaard, Ole S.] Aarhus Univ Hosp, Dept Infect Dis, DK-8200 Aarhus N, Denmark.
[Jorgensen, Martin R. S.] Aarhus Univ Hosp, Aalborg Hosp, Dept Infect Dis, Aalborg, Denmark.
[Bjerrum, Stephanie] Hvidovre Univ Hosp, Dept Infect Dis, DK-2650 Hvidovre, Denmark.
[Stovring, Henrik] Aarhus Univ, Dept Publ Hlth, Aarhus, Denmark.
RP Rasmussen, TA (reprint author), Aarhus Univ Hosp, Dept Infect Dis, DK-8200 Aarhus N, Denmark.
EM thomrasm@rm.dk
RI Stovring, Henrik/I-4683-2012
OI Stovring, Henrik/0000-0002-5821-2351
FU Department of Infectious Diseases, Aarhus University Hospital, Denmark;
Aarhus University Hospital
FX The study was funded by the Department of Infectious Diseases, Aarhus
University Hospital, Denmark.All authors have completed the Unified
Competing Interest form at www.icmje.org/coi_disclosure.pdf (available
on request from the corresponding author) and declare: support from
Aarhus University Hospital for the submitted work; no financial
relationships with any organisations that might have an interest in the
submitted work in the previous 3 years; no other relationships or
activities that could appear to have influenced the submitted work.
CR [Anonymous], 2011, PRESCRIRE INT, V20, P154
Arcond MF, 2011, MEDICINA-BUENOS AIRE, V71, P161
Bardage C, 2011, BRIT MED J, V343, DOI 10.1136/bmj.d5956
Berlin JA, 2008, AM J PUBLIC HEALTH, V98, P1366, DOI 10.2105/AJPH.2007.124537
Black S, 2009, LANCET, V374, P2115, DOI 10.1016/S0140-6736(09)61877-8
Choe YJ, 2011, VACCINE, V29, P2066, DOI 10.1016/j.vaccine.2011.01.007
Christiansen CF, 2010, NEUROEPIDEMIOLOGY, V35, P267, DOI 10.1159/000320245
Deeks SL, 2011, BMC PUBLIC HEALTH, V11, DOI 10.1186/1471-2458-11-329
DeStefano F, 2010, LANCET, V375, P1146, DOI 10.1016/S0140-6736(09)61917-6
Dieleman J, 2011, BRIT MED J, V343, DOI 10.1136/bmj.d3908
Folkenberg M, 2011, VACCINE, V29, P1180, DOI 10.1016/j.vaccine.2010.12.008
Haba-Rubio J, 2011, REV NEUROL-FRANCE, V167, P563, DOI 10.1016/j.neurol.2011.04.003
Honda H, 2005, J CHILD PSYCHOL PSYC, V46, P572, DOI 10.1111/j.1469-7610.2005.01425.x
Huang WT, 2010, LANCET, V375, P1164, DOI 10.1016/S0140-6736(10)60515-6
Hviid A, 2008, AM J EPIDEMIOL, V168, P1277, DOI 10.1093/aje/kwn253
Institute of Medicine, 2010, ADV EFF VACC EV CAUS
Jansen VAA, 2003, SCIENCE, V301, P804, DOI 10.1126/science.1086726
Jiang GX, 1997, J NEUROL NEUROSUR PS, V62, P447, DOI 10.1136/jnnp.62.5.447
Klein NP, 2010, VACCINE, V28, P1062, DOI 10.1016/j.vaccine.2009.10.115
Kokia ES, 2007, VACCINE, V25, P8557, DOI 10.1016/j.vaccine.2007.10.021
Larson HJ, 2011, LANCET, V378, P526, DOI 10.1016/S0140-6736(11)60678-8
Lieu TA, 2007, MED CARE, V45, pS89
Löwer Johannes, 2008, MMW Fortschr Med, V150, P6
Madsen KM, 2002, NEW ENGL J MED, V347, P1477, DOI 10.1056/NEJMoa021134
Madsen KM, 2004, DRUG SAFETY, V27, P831, DOI 10.2165/00002018-200427120-00001
Mitrakrishnan S, 2011, VACCINE, V29, P6369, DOI 10.1016/j.vaccine.2011.04.126
Norgaard M, 2007, PHARMACOEPIDEM DR S, V16, pS220
Norgaard M, 2011, BLOOD, V117, P3514, DOI 10.1182/blood-2010-10-312819
Salmon DA, 2011, PEDIATRICS, V127, pS78, DOI 10.1542/peds.2010-1722L
Sato N, 2011, INTERNAL MED, V50, P503, DOI 10.2169/internalmedicine.50.4340
Siegrist CA, 2007, PEDIATR INFECT DIS J, V26, P979, DOI 10.1097/INF.0b013e318149dfea
Statens Serum Institut, VACC SURV
Statens Serum Institut, 2011, DTAP IPV HIB VACC CO
Statens Serum Institut, 2011, MMR VACC COV 2010
Statens Serum Institut, 2011, PCV COV INV PNEUM DI
Statens Serum Institut, 2011, HPV VACC COV 2010
Sun YL, 2012, JAMA-J AM MED ASSOC, V307, P823, DOI 10.1001/jama.2012.165
Svanstrom H, 2010, DRUG SAFETY, V33, P1015, DOI 10.2165/11537630-000000000-00000
Thomsen RW, 2004, DIABETES CARE, V27, P70, DOI 10.2337/diacare.27.1.70
Vestergaard M, 2006, J CLIN EPIDEMIOL, V59, P61, DOI 10.1016/j.jclinepi.2005.05.008
Wakefield AJ, 1999, LANCET, V354, P949, DOI 10.1016/S0140-6736(05)75696-8
Wijnans L, 2011, VACCINE, V29, P7559, DOI 10.1016/j.vaccine.2011.08.016
Williams SE, 2011, VACCINE
Wu JA, 2010, NEW ENGL J MED, V363, P2416, DOI 10.1056/NEJMoa1006736
Yin JK, 2011, INFLUENZA OTHER RESP, V5, P299, DOI 10.1111/j.1750-2659.2011.00229.x
NR 45
TC 5
Z9 5
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 1756-1833
J9 BRIT MED J
JI Br. Med. J.
PD SEP 17
PY 2012
VL 345
AR e5823
DI 10.1136/bmj.e5823
PG 12
WC Medicine, General & Internal
SC General & Internal Medicine
GA 011JG
UT WOS:000309160300001
PM 22988304
ER
PT J
AU Etain, B
Dumaine, A
Bellivier, F
Pagan, C
Francelle, L
Goubran-Botros, H
Moreno, S
Deshommes, J
Moustafa, K
Le Dudal, K
Mathieu, F
Henry, C
Kahn, JP
Launay, JM
Muhleisen, TW
Cichon, S
Bourgeron, T
Leboyer, M
Jamain, S
AF Etain, Bruno
Dumaine, Anne
Bellivier, Frank
Pagan, Cecile
Francelle, Laetitia
Goubran-Botros, Hany
Moreno, Sarah
Deshommes, Jasmine
Moustafa, Khaled
Le Dudal, Katia
Mathieu, Flavie
Henry, Chantal
Kahn, Jean-Pierre
Launay, Jean-Marie
Muehleisen, Thomas W.
Cichon, Sven
Bourgeron, Thomas
Leboyer, Marion
Jamain, Stephane
TI Genetic and functional abnormalities of the melatonin biosynthesis
pathway in patients with bipolar disorder
SO HUMAN MOLECULAR GENETICS
LA English
DT Article
ID AUTISM SPECTRUM DISORDERS; I DISORDER; CIRCADIAN ACTIVITY; MOOD
DISORDERS; SLEEP PATTERNS; DRUG-FREE; LIGHT; SUSCEPTIBILITY;
SENSITIVITY; EXPRESSION
AB Patients affected by bipolar disorder (BD) frequently report abnormalities in sleep/wake cycles. In addition, they showed abnormal oscillating melatonin secretion, a key regulator of circadian rhythms and sleep patterns. The acetylserotonin O-methyltransferase (ASMT) is a key enzyme of the melatonin biosynthesis and has recently been associated with psychiatric disorders such as autism spectrum disorders and depression. In this paper, we analysed rare and common variants of ASMT in patients with BD and unaffected control subjects and performed functional analysis of these variants by assaying the ASMT activity in their B-lymphoblastoid cell lines. We sequenced the coding and the regulatory regions of the gene in a discovery sample of 345 patients with BD and 220 controls. We performed an association study on this discovery sample using common variants located in the promoter region and showed that rs4446909 was significantly associated with BD (P 0.01) and associated with a lower mRNA level (P 10(4)) and a lower enzymatic activity (P 0.05) of ASMT. A replication study and a meta-analysis using 480 independent patients with BD and 672 controls confirmed the significant association between rs4446909 and BD (P 0.002). These results correlate with the general lower ASMT enzymatic activity observed in patients with BD (P 0.001) compared with controls. Finally, several deleterious ASMT mutations identified in patients were associated with low ASMT activity (P 0.01). In this study, we determined how rare and common variations in ASMT might play a role in BD vulnerability and suggest a general role of melatonin as susceptibility factor for BD.
C1 [Jamain, Stephane] Hop H Mondor, INSERM, U955, EQ15, F-94000 Creteil, France.
[Etain, Bruno; Bellivier, Frank; Deshommes, Jasmine; Henry, Chantal; Leboyer, Marion] Hop H Mondor A Chenevier, AP HP, F-94000 Creteil, France.
[Bellivier, Frank; Henry, Chantal; Leboyer, Marion] Univ Paris Est, Fac Med, F-94000 Creteil, France.
[Etain, Bruno; Dumaine, Anne; Bellivier, Frank; Pagan, Cecile; Francelle, Laetitia; Goubran-Botros, Hany; Moreno, Sarah; Deshommes, Jasmine; Moustafa, Khaled; Le Dudal, Katia; Mathieu, Flavie; Henry, Chantal; Kahn, Jean-Pierre; Launay, Jean-Marie; Bourgeron, Thomas; Leboyer, Marion; Jamain, Stephane] Fondat Fondamental, F-94000 Creteil, France.
[Pagan, Cecile; Goubran-Botros, Hany; Moreno, Sarah; Bourgeron, Thomas] Inst Pasteur, F-75015 Paris, France.
[Pagan, Cecile; Goubran-Botros, Hany; Moreno, Sarah; Bourgeron, Thomas] Inst Pasteur, CNRS, URA Genes Synapses & Cognit 2182, Paris, France.
[Pagan, Cecile; Launay, Jean-Marie] Hop Lariboisiere, AP HP, Serv Biochim, Fac Pharm, F-75475 Paris, France.
[Le Dudal, Katia] Hop H Mondor A Chenevier, INSERM, Ctr Invest Clin 006, F-94000 Creteil, France.
[Kahn, Jean-Pierre] Hop Jeanne dArc, CHU Nancy, Dept Psychiat & Psychol Clin, F-54200 Toul, France.
[Muehleisen, Thomas W.; Cichon, Sven] Univ Bonn, Dept Genom, Life & Brain Ctr, D-53127 Bonn, Germany.
[Muehleisen, Thomas W.; Cichon, Sven] Univ Bonn, Inst Human Genet, D-53127 Bonn, Germany.
[Cichon, Sven] Res Ctr Juelich, Inst Neurosci & Med INM 1, D-52425 Julich, Germany.
RP Jamain, S (reprint author), Hop H Mondor, INSERM, U955, EQ15, 51 Av Marechal de Lattre de Tassigny, F-94000 Creteil, France.
EM stephane.jamain@inserm.fr
RI Cichon, Sven/H-8803-2013; Cichon, Sven/B-9618-2014
OI Cichon, Sven/0000-0002-9475-086X; Cichon, Sven/0000-0002-9475-086X
FU Institut Pasteur; Institut National pour la Recherche Medicale (INSERM);
Assistance Publique des Hopitaux de Paris (AP-HP); Agence Nationale pour
la Recherche (ANR); Fondation pour la Recherche sur le Cerveau (FRC);
Reseau Thematique de Recherche et de Soin en Sante Mentale (Fondation
FondaMental)
FX This work was supported by the Institut Pasteur; the Institut National
pour la Recherche Medicale (INSERM); the Assistance Publique des
Hopitaux de Paris (AP-HP); the Agence Nationale pour la Recherche (ANR -
Project Manage_BPAD); the Fondation pour la Recherche sur le Cerveau
(FRC); and the Reseau Thematique de Recherche et de Soin en Sante
Mentale (Fondation FondaMental).
CR Ahn YM, 2008, BIPOLAR DISORD, V10, P271, DOI 10.1111/j.1399-5618.2007.00573.x
American Psychiatric Association (APA), 1994, DIAGN STAT MAN MENT, V4th
Cai GQ, 2008, BMC MED GENOMICS, V1, DOI 10.1186/1755-8794-1-50
Calabrese JR, 2007, BIPOLAR DISORD, V9, P628, DOI 10.1111/j.1399-5618.2007.00507.x
Chaste P, 2011, J PINEAL RES, V51, P394, DOI 10.1111/j.1600-079X.2011.00902.x
Cichon S, 2011, AM J HUM GENET, V88, P372, DOI 10.1016/j.ajhg.2011.01.017
Dallaspezia S, 2009, CURR PSYCHIAT REP, V11, P488
Duffy Anne, 2009, J Can Acad Child Adolesc Psychiatry, V18, P200
Etain B, 2010, MOL PSYCHIATR, V15, P748, DOI 10.1038/mp.2008.148
FINOCCHIARO LME, 1991, BIOCHEM J, V280, P727
Flaquer A, 2010, AM J MED GENET B, V153B, P1110, DOI 10.1002/ajmg.b.31075
Frank E, 2000, BIOL PSYCHIAT, V48, P593, DOI 10.1016/S0006-3223(00)00969-0
Galecki P, 2010, J PINEAL RES, V48, P311, DOI 10.1111/j.1600-079X.2010.00754.x
Gruber J, 2009, J AFFECT DISORDERS, V114, P41, DOI 10.1016/j.jad.2008.06.028
Hallam KT, 2005, AUST NZ J PSYCHIAT, V39, P947
Hallam KT, 2006, PSYCHONEUROENDOCRINO, V31, P867, DOI 10.1016/j.psyneuen.2006.04.004
Harvey AG, 2011, CLIN PSYCHOL REV, V31, P225, DOI 10.1016/j.cpr.2010.04.003
Harvey AG, 2009, CHILD ADOL PSYCH CL, V18, P321, DOI 10.1016/j.chc.2008.11.006
Harvey AG, 2008, AM J PSYCHIAT, V165, P820, DOI 10.1176/appi.ajp.2008.08010098
Johnson KP, 2009, CHILD ADOL PSYCH CL, V18, P917, DOI 10.1016/j.chc.2009.04.001
Jones SH, 2005, BIPOLAR DISORD, V7, P176, DOI 10.1111/j.1399-5618.2005.00187.x
Jonsson L, 2010, BMC MED GENOMICS, V3, DOI 10.1186/1755-8794-3-10
Kennedy SH, 1996, PSYCHIAT RES, V63, P219, DOI 10.1016/0165-1781(96)02910-1
KENNEDY SH, 1989, J NERV MENT DIS, V177, P300, DOI 10.1097/00005053-198905000-00009
Kripke Daniel F, 2011, J Circadian Rhythms, V9, P8, DOI 10.1186/1740-3391-9-8
Leboyer M, 2010, J CLIN PSYCHIAT, V71, P1689, DOI 10.4088/JCP.10m06347yel
Lewy AJ, 2009, CURR PSYCHIAT REP, V11, P459
LEWY AJ, 1985, AM J PSYCHIAT, V142, P725
Livak KJ, 2001, METHODS, V25, P402, DOI 10.1006/meth.2001.1262
Mansour HA, 2005, CHRONOBIOL INT, V22, P571, DOI 10.1081/CBI-200062413
McClung CA, 2007, PHARMACOL THERAPEUT, V114, P222, DOI 10.1016/j.pharmthera.2007.02.003
Melke J, 2008, MOL PSYCHIATR, V13, P90, DOI 10.1038/sj.mp.4002016
Mendlewicz J, 2009, CNS DRUGS, V23, P15, DOI 10.2165/11318630-000000000-00000
Millar A, 2004, J AFFECT DISORDERS, V80, P145, DOI 10.1016/S0165-0327(03)00055-7
Muhleisen TW, 2011, SCHIZOPHR RES, V127, P35, DOI 10.1016/j.schres.2011.01.001
Nathan PJ, 1999, NEUROPSYCHOPHARMACOL, V21, P408, DOI 10.1016/S0893-133X(99)00018-4
NURNBERGER JI, 1988, NEUROPSYCHOPHARMACOL, V1, P217, DOI 10.1016/0893-133X(88)90020-6
Nurnberger JI, 2000, ARCH GEN PSYCHIAT, V57, P572, DOI 10.1001/archpsyc.57.6.572
Pacchierotti C, 2001, FRONT NEUROENDOCRIN, V22, P18, DOI 10.1006/frne.2000.0202
Pandi-Perumal SR, 2006, FEBS J, V273, P2813, DOI 10.1111/j.1742-4658.2006.05322.x
Purcell S, 2007, AM J HUM GENET, V81, P559, DOI 10.1086/519795
Reiter RJ, 2009, CRIT REV BIOCHEM MOL, V44, P175, DOI 10.1080/10409230903044914
Salvatore P, 2008, BIPOLAR DISORD, V10, P256, DOI 10.1111/j.1399-5618.2007.00505.x
Skjelstad DV, 2010, J AFFECT DISORDERS, V126, P1, DOI 10.1016/j.jad.2009.10.003
Soria V, 2010, J PINEAL RES, V49, P35, DOI 10.1111/j.1600-079X.2010.00763.x
Tantam D, 2009, BRIT MED BULL, V89, P41, DOI 10.1093/bmb/ldp006
Toma C, 2007, MOL PSYCHIATR, V12, P977, DOI 10.1038/sj.mp.4002069
Walters Arthur S, 2008, J Clin Sleep Med, V4, P591
WHALLEY LJ, 1991, PSYCHIAT RES, V38, P13, DOI 10.1016/0165-1781(91)90048-T
Wood J, 2009, PSYCHIAT RES, V166, P201, DOI 10.1016/j.psychres.2008.03.003
Yang S, 2009, MOL PSYCHIATR, V14, P143, DOI 10.1038/mp.2008.10
NR 51
TC 22
Z9 22
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0964-6906
J9 HUM MOL GENET
JI Hum. Mol. Genet.
PD SEP 15
PY 2012
VL 21
IS 18
BP 4030
EP 4037
DI 10.1093/hmg/dds227
PG 8
WC Biochemistry & Molecular Biology; Genetics & Heredity
SC Biochemistry & Molecular Biology; Genetics & Heredity
GA 998IJ
UT WOS:000308230800008
PM 22694957
ER
PT J
AU Xu, FL
Farkas, S
Kortbeek, S
Zhang, FX
Chen, LN
Zamponi, GW
Syed, NI
AF Xu, Fenglian
Farkas, Svetlana
Kortbeek, Simone
Zhang, Fang-Xiong
Chen, Lina
Zamponi, Gerald W.
Syed, Naweed I.
TI Mercury-induced toxicity of rat cortical neurons is mediated through
N-methyl-D-Aspartate receptors
SO MOLECULAR BRAIN
LA English
DT Article
DE Mercury Chloride; Rat cortical neurons; Toxicity; MK 801; NMDA receptor;
Excitotoxicity; Cytoskeleton
ID CEREBELLAR GRANULE CELLS; METHYLMERCURY-INDUCED NEUROTOXICITY; NERVE
GROWTH-FACTOR; IN-VITRO; NEUROBLASTOMA-CELLS; HIPPOCAMPAL-NEURONS;
PERMEABILITY TRANSITION; GLUTAMATE TRANSPORT; ALZHEIMERS-DISEASE;
NEURITE OUTGROWTH
AB Background: Mercury is a well-known neurotoxin implicated in a wide range of neurological or psychiatric disorders including autism spectrum disorders, Alzheimer's disease, Parkinson's disease, epilepsy, depression, mood disorders and tremor. Mercury-induced neuronal degeneration is thought to invoke glutamate-mediated excitotoxicity, however, the underlying mechanisms remain poorly understood. Here, we examine the effects of various mercury concentrations (including pathological levels present in human plasma or cerebrospinal fluid) on cultured, rat cortical neurons.
Results: We found that inorganic mercuric chloride (HgCl2 -at 0.025 to 25 mu M) not only caused neuronal degeneration but also perturbed neuronal excitability. Whole-cell patch-clamp recordings of pyramidal neurons revealed that HgCl2 not only enhanced the amplitude and frequency of synaptic, inward currents, but also increased spontaneous synaptic potentials followed by sustained membrane depolarization. HgCl2 also triggered sustained, 2-5 fold rises in intracellular calcium concentration ([Ca2+](i)). The observed increases in neuronal activity and [Ca2+](i) were substantially reduced by the application of MK 801, a non-competitive antagonist of N-Methyl-D-Aspartate (NMDA) receptors. Importantly, our study further shows that a pre incubation or co-application of MK 801 prevents HgCl2-induced reduction of cell viability and a disruption of beta-tubulin.
Conclusions: Collectively, our data show that HgCl2-induced toxic effects on central neurons are triggered by an over-activation of NMDA receptors, leading to cytoskeleton instability.
C1 [Xu, Fenglian; Farkas, Svetlana; Kortbeek, Simone; Syed, Naweed I.] Univ Calgary, Dept Cell Biol & Anat, Calgary, AB T2N 1N4, Canada.
[Xu, Fenglian; Zhang, Fang-Xiong; Chen, Lina; Zamponi, Gerald W.] Univ Calgary, Hotchkiss Brain Inst, Fac Med, Calgary, AB T2N 1N4, Canada.
RP Xu, FL (reprint author), Univ Calgary, Dept Cell Biol & Anat, Calgary, AB T2N 1N4, Canada.
EM fxu@ucalgary.ca
FU Natural Sciences and Engineering Research Council (NSERC); Canadian
Institutes of Health Research (CIHR); Hotchkiss Brain Institute Fong
fellowship; Alberta Innovate-Health Solutions fellowship
FX This work was supported by Natural Sciences and Engineering Research
Council (NSERC) grant to NIS. GWZ is supported by a grant from the
Canadian Institutes of Health Research (CIHR). He is a Canada research
Chair and AI-HS Scientist. FXZ is supported by the Hotchkiss Brain
Institute Fong fellowship and Alberta Innovate-Health Solutions
fellowship.
CR Aizenman E, 1989, NEURON, V2, P1257
Allen JW, 2001, BRAIN RES, V891, P148, DOI 10.1016/S0006-8993(00)03185-1
ALMOHANNA FA, 1992, DEV BRAIN RES, V70, P287, DOI 10.1016/0165-3806(92)90209-F
Ankarcrona M, 1996, FEBS LETT, V394, P321, DOI 10.1016/0014-5793(96)00959-3
ASCHNER M, 1990, NEUROSCI BIOBEHAV R, V14, P169, DOI 10.1016/S0149-7634(05)80217-9
Aschner M, 2000, NEUROCHEM INT, V37, P199, DOI 10.1016/S0197-0186(00)00023-1
ATCHISON WD, 1994, FASEB J, V8, P622
Basu N, 2007, NEUROTOXICOLOGY, V28, P587, DOI 10.1016/j.neuro.2006.12.007
Blankenship AG, 2010, NAT REV NEUROSCI, V11, P18, DOI 10.1038/nrn2759
BROOKES N, 1992, TOXICOLOGY, V76, P245, DOI 10.1016/0300-483X(92)90193-I
CADRIN M, 1988, CELL BIOL TOXICOL, V4, P61, DOI 10.1007/BF00141287
Castoldi AF, 2001, BRAIN RES BULL, V55, P197, DOI 10.1016/S0361-9230(01)00458-0
Castoldi AF, 2000, J NEUROSCI RES, V59, P775, DOI 10.1002/(SICI)1097-4547(20000315)59:6<775::AID-JNR10>3.0.CO;2-T
Charleston JS, 1996, NEUROTOXICOLOGY, V17, P127
CHOI BH, 1988, ACTA NEUROPATHOL, V75, P325
Chung RS, 2005, EXP NEUROL, V193, P481, DOI 10.1016/j.expneurol.2005.01.005
Clarkson TW, 2006, CRIT REV TOXICOL, V36, P609, DOI 10.1080/10408440600845619
Clarkson TW, 2002, ENVIRON HEALTH PERSP, V110, P11
Clarkson TW, 2003, NEW ENGL J MED, V349, P1731, DOI 10.1056/NEJMra022471
Eto K, 2001, TOXICOL PATHOL, V29, P565, DOI 10.1080/019262301317226375
Farina M, 2011, LIFE SCI, V89, P555, DOI 10.1016/j.lfs.2011.05.019
Feng J, 2006, NEUROSCIENTIST, V12, P469, DOI 10.1177/1073858406293853
Ferraro L, 2009, INT J DEV NEUROSCI, V27, P165, DOI 10.1016/j.ijdevneu.2008.11.004
Fonfria E, 2005, J NEUROSCI RES, V79, P545, DOI 10.1002/jnr.20375
FRIBERG L, 1989, BIOL TRACE ELEM RES, V21, P201, DOI 10.1007/BF02917253
Gopal KV, 2003, NEUROTOXICOL TERATOL, V25, P365, DOI 10.1016/S0892-0362(03)00037-0
Hock C, 1998, J NEURAL TRANSM, V105, P59, DOI 10.1007/s007020050038
InSug O, 1997, TOXICOLOGY, V124, P211, DOI 10.1016/S0300-483X(97)00153-4
Johansson C, 2007, NEUROTOX RES, V11, P241
Juarez BI, 2005, TOXICOLOGY, V207, P223, DOI 10.1016/j.tox.2004.09.007
KATER SB, 1991, J NEUROSCI, V11, P891
KOIKE T, 1983, BRAIN RES, V289, P293, DOI 10.1016/0006-8993(83)90030-6
Korogi Y, 2011, AM J NEURORADIOL, V1994, P1575
LAZAREWICZ JW, 1989, NEUROSCI RES COMMUN, V4, P91
Leong CCW, 2001, NEUROREPORT, V12, P733, DOI 10.1097/00001756-200103260-00024
Limke TL, 2002, TOXICOL APPL PHARM, V178, P52, DOI 10.1006/taap.2001.9327
MATTSON MP, 1987, J NEUROSCI, V7, P4034
MATTSON MP, 1992, EXP GERONTOL, V27, P29, DOI 10.1016/0531-5565(92)90027-W
MATTSON MP, 1991, MOL CHEM NEUROPATHOL, V15, P117
Mattson MP, 1999, J NEUROSCI RES, V58, P152, DOI 10.1002/(SICI)1097-4547(19991001)58:1<152::AID-JNR15>3.0.CO;2-V
Meyer-Baron M, 2002, ARCH TOXICOL, V76, P127, DOI 10.1007/s00204-002-0327-9
MIURA K, 1984, TOXICOL APPL PHARM, V73, P218, DOI 10.1016/0041-008X(84)90327-2
Miyamoto K, 2001, BRAIN RES, V901, P252, DOI 10.1016/S0006-8993(01)02281-8
Mutter J, 2005, NEUROENDOCRINOL LETT, V26, P439
Mutter J, 2007, FORTSCHR NEUROL PSYC, V75, P528, DOI 10.1055/s-2007-959237
Ndountse LT, 2008, TOXICOLOGY, V249, P251, DOI 10.1016/j.tox.2008.05.011
Olivieri G, 2000, J NEUROCHEM, V74, P231, DOI 10.1046/j.1471-4159.2000.0740231.x
Orrenius S, 2003, NAT REV MOL CELL BIO, V4, P552, DOI 10.1038/nrm1150
PEKEL M, 1993, BRAIN RES, V632, P121, DOI 10.1016/0006-8993(93)91146-J
Pendergrass JC, 1997, MET IONS BIOL SYST, V34, P461
Peng SQ, 2002, J PHARMACOL EXP THER, V302, P424, DOI 10.1124/jpet.102.032748
Pivovarova NB, 2004, J NEUROSCI, V24, P5611, DOI 10.1523/JNEUROSCI.0531-04.2004
Poulain FE, 2010, MOL CELL NEUROSCI, V43, P15, DOI 10.1016/j.mcn.2009.07.012
Rao A, 1997, NEURON, V19, P801, DOI 10.1016/S0896-6273(00)80962-9
SCHUBERT D, 1978, NATURE, V273, P718, DOI 10.1038/273718a0
Shu YS, 2003, NATURE, V423, P288, DOI 10.1038/nature01616
Sieger FAS, 2012, MED HYPOTHESES, V79, P13, DOI 10.1016/j.mehy.2012.03.022
Sirois JE, 1996, NEUROTOXICOLOGY, V17, P63
Slemmer JE, 2005, PROG BRAIN RES, V148, P367, DOI 10.1016/S0079-6123(04)48029-7
de Assis GPS, 2003, COMP BIOCHEM PHYS C, V134, P375
Stoiber T, 2004, TOXICOL LETT, V151, P99, DOI 10.1016/j.toxlet.2003.11.017
Sziics A, 1997, CELL MOL NEUROBIOL, V17, P273
TANG LH, 1993, J PHYSIOL-LONDON, V465, P303
Thivierge JP, 2009, NEURAL NETWORKS, V22, P901, DOI 10.1016/j.neunet.2009.01.001
WEISENBE.RC, 1972, SCIENCE, V177, P1104, DOI 10.1126/science.177.4054.1104
Wiggers GA, 2008, COMP BIOCHEM PHYS C, V147, P252, DOI 10.1016/j.cbpc.2007.10.003
Xu F, 2018, EUR J NEUROSCI, V31, P994
Yuan Y, 2003, J PHYSIOL-LONDON, V550, P191, DOI 10.1113/jphysiol.2003.040543
Yuan YK, 2005, J PHARMACOL EXP THER, V313, P751, DOI 10.1124/jpet.104.080721
NR 69
TC 7
Z9 7
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1756-6606
J9 MOL BRAIN
JI Mol. Brain
PD SEP 14
PY 2012
VL 5
AR 30
DI 10.1186/1756-6606-5-30
PG 14
WC Neurosciences
SC Neurosciences & Neurology
GA 019NO
UT WOS:000309746800001
PM 22980357
ER
PT J
AU State, MW
Sestan, N
AF State, Matthew W.
Sestan, Nenad
TI The Emerging Biology of Autism Spectrum Disorders
SO SCIENCE
LA English
DT Editorial Material
ID DE-NOVO MUTATIONS; BRAIN; CHILDREN
C1 [State, Matthew W.] Yale Univ, Sch Med, Ctr Child Study, New Haven, CT 06510 USA.
[State, Matthew W.] Yale Univ, Sch Med, Dept Psychiat, New Haven, CT 06510 USA.
[Sestan, Nenad] Yale Univ, Sch Med, Dept Neurobiol, New Haven, CT 06510 USA.
RP State, MW (reprint author), Yale Univ, Sch Med, Ctr Child Study, 333 Cedar St, New Haven, CT 06510 USA.
EM matthew.state@yale.edu; nenad.sestan@yale.edu
CR Iossifov I, 2012, NEURON, V74, P285, DOI 10.1016/j.neuron.2012.04.009
Jamain S, 2003, NAT GENET, V34, P27, DOI 10.1038/ng1136
Kang HJ, 2011, NATURE, V478, P483, DOI 10.1038/nature10523
Kwan KY, 2012, CELL, V149, P899, DOI 10.1016/j.cell.2012.02.060
Neale BM, 2012, NATURE, V485, P242, DOI 10.1038/nature11011
O'Roak BJ, 2012, NATURE, V485, P246, DOI 10.1038/nature10989
O'Roak BJ, 2011, NAT GENET, V43, P585, DOI 10.1038/ng.835
Rapoport JL, 2008, NEUROPSYCHOPHARMACOL, V33, P181, DOI 10.1038/sj.npp.1301553
Sanders SJ, 2012, NATURE, V485, P237, DOI 10.1038/nature10945
Sebat J, 2007, SCIENCE, V316, P445, DOI 10.1126/science.1138659
State MW, 2011, NAT NEUROSCI, V14, P1499, DOI 10.1038/nn.2924
Szatmari P, 2007, NAT GENET, V39, P319, DOI 10.1038/ng1985
Walsh CA, 2008, CELL, V135, P396, DOI 10.1016/j.cell.2008.10.015
Zoghbi HY, 2012, CSH PERSPECT BIOL, V4, DOI 10.1101/cshperspect.a009886
NR 14
TC 39
Z9 40
PU AMER ASSOC ADVANCEMENT SCIENCE
PI WASHINGTON
PA 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA
SN 0036-8075
J9 SCIENCE
JI Science
PD SEP 14
PY 2012
VL 337
IS 6100
BP 1301
EP 1303
DI 10.1126/science.1224989
PG 3
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 004TW
UT WOS:000308705000028
PM 22984058
ER
PT J
AU DePape, AMR
Hall, GBC
Tillmann, B
Trainor, LJ
AF DePape, Anne-Marie R.
Hall, Geoffrey B. C.
Tillmann, Barbara
Trainor, Laurel J.
TI Auditory Processing in High-Functioning Adolescents with Autism Spectrum
Disorder
SO PLOS ONE
LA English
DT Article
ID MIRROR NEURON SYSTEM; ABSOLUTE PITCH; SPEECH-PERCEPTION;
ASPERGER-SYNDROME; DEVELOPMENTAL DISORDERS; PRESCHOOL-CHILDREN; MUSICAL
EXPERIENCE; EARLY RECOGNITION; HOME VIDEOTAPES; NEWBORN-INFANTS
AB Autism Spectrum Disorder (ASD) is a pervasive developmental disorder including abnormalities in perceptual processing. We measure perception in a battery of tests across speech (filtering, phoneme categorization, multisensory integration) and music (pitch memory, meter categorization, harmonic priming). We found that compared to controls, the ASD group showed poorer filtering, less audio-visual integration, less specialization for native phonemic and metrical categories, and a higher instance of absolute pitch. No group differences were found in harmonic priming. Our results are discussed in a developmental framework where culture-specific knowledge acquired early compared to late in development is most impaired, perhaps because of early-accelerated brain growth in ASD. These results suggest that early auditory remediation is needed for good communication and social functioning.
C1 [DePape, Anne-Marie R.; Hall, Geoffrey B. C.; Trainor, Laurel J.] McMaster Univ, Hamilton, ON, Canada.
[Trainor, Laurel J.] Baycrest Hosp, Rotman Res Inst, Toronto, ON, Canada.
[Tillmann, Barbara] Univ Lyon 1, INSERM U1028, CNRS UMR 5292, Lyon Neurosci Res Ctr,Auditory Cognit & Psychoaco, F-69365 Lyon, Rhone Alpes, France.
RP DePape, AMR (reprint author), McMaster Univ, Hamilton, ON, Canada.
EM ljt@mcmaster.ca
FU Natural Sciences and Engineering Research Council of Canada; Social
Sciences and Humanities Research Council of Canada
FX This research was supported by a grant from the Natural Sciences and
Engineering Research Council of Canada to LJT and a graduate fellowship
from the Social Sciences and Humanities Research Council of Canada to
ARD. The funders had no role in study design, data collection and
analysis, decision to publish, or preparation of the manuscript.
CR Alcantara JI, 2004, J CHILD PSYCHOL PSYC, V45, P1107, DOI 10.1111/j.1469-7610.2004.t01-1-00303.x
Allen R, 2009, AUTISM, V13, P21, DOI 10.1177/1362361307098511
Allen R, 2010, MUSIC PERCEPT, V27, P251, DOI 10.1525/MP.2010.27.4.251
Ashburner J, 2008, AM J OCCUP THER, V62, P564
BACHEM A, 1955, J ACOUST SOC AM, V27, P1180, DOI 10.1121/1.1908155
Baharloo S, 1998, AM J HUM GENET, V62, P224, DOI 10.1086/301704
Baker AEZ, 2008, J AUTISM DEV DISORD, V38, P867, DOI 10.1007/s10803-007-0459-0
Baranek GT, 2007, AM J MENT RETARD, V112, P233, DOI 10.1352/0895-8017(2007)112[233:HSPIYC]2.0.CO;2
Baranek GT, 1999, J AUTISM DEV DISORD, V29, P213, DOI 10.1023/A:1023080005650
Barnea-Goraly N, 2004, BIOL PSYCHIAT, V55, P323, DOI 10.1016/j.biopsych.2003.10.022
BaronCohen S, 1997, J COGNITIVE NEUROSCI, V9, P548, DOI 10.1162/jocn.1997.9.4.548
Best CT, 2001, J ACOUST SOC AM, V109, P775, DOI 10.1121/1.1332378
Bigand E, 2003, J EXP PSYCHOL HUMAN, V29, P159, DOI 10.1037/0096-1523.29.1.159
Bigand E, 1999, J EXP PSYCHOL HUMAN, V25, P184, DOI 10.1037/0096-1523.25.1.184
Bird G, 2006, NEUROIMAGE, V31, P1614, DOI 10.1016/j.neuroimage.2006.02.037
Boddaert N, 2004, AM J PSYCHIAT, V161, P2117, DOI 10.1176/appi.ajp.161.11.2117
Brenton JN, 2008, PEDIATR NEUROL, V39, P137, DOI 10.1016/j.pediatrneurol.2008.05.004
Brown WA, 2003, J AUTISM DEV DISORD, V33, P163, DOI 10.1023/A:1022987309913
Calvert GA, 2000, CURR BIOL, V10, P649, DOI 10.1016/S0960-9822(00)00513-3
Casanova MF, 2004, EUR ARCH PSY CLIN N, V254, P148, DOI 10.1007/s00406-004-0457-6
Casanova MF, 2002, NEUROLOGY, V58, P428
Castelli F, 2002, BRAIN, V125, P1839, DOI 10.1093/brain/awf189
Clayton M., 2000, TIME INDIAN MUSIC
Constantino JN, 2007, J AUTISM DEV DISORD, V37, P1256, DOI 10.1007/s10803-006-0269-9
Corrigall KA, 2010, MUSIC PERCEPT, V28, P195, DOI 10.1525/mp.2010.28.2.195
Costa-Giomi E, 2003, ANN NY ACAD SCI, V999, P477, DOI 10.1196/annals.1284.058
Courchesne E, 2001, NEUROLOGY, V57, P245
Courchesne E, 2005, CURR OPIN NEUROBIOL, V15, P225, DOI 10.1016/j.conb.2005.03.001
Courchesne E, 2003, JAMA-J AM MED ASSOC, V290, P337, DOI 10.1001/jama.290.3.337
Courchesne E, 2004, MENT RETARD DEV D R, V10, P106, DOI 10.1002/mrdd.20020
Dahlgren SV, 1989, AUTISM NATURE DIAGNO, P49
Dawson G, 2005, DEV NEUROPSYCHOL, V27, P403, DOI 10.1207/s15326942dn2703_6
Dawson G, 2004, DEV PSYCHOL, V40, P271, DOI 10.1037/0012-1649.40.2.271
Dawson G, 1998, J AUTISM DEV DISORD, V28, P479, DOI 10.1023/A:1026043926488
De Gelder B, 1991, EUROPEAN J COGNITIVE, V3, P69, DOI 10.1080/09541449108406220
DEMANY L, 1982, INFANT BEHAV DEV, V5, P261, DOI 10.1016/S0163-6383(82)80036-2
Dunn L. M., 1997, PEABODY PICTURE VOCA, V3rd
Fassbender C., 1993, AUDITORY GROUPING SE
Finnigan E, 2010, AUTISM, V14, P321, DOI 10.1177/1362361309357747
Folland NA, 2012, J ACOUST SOC AM, V131, P993, DOI 10.1121/1.3651254
Frith U., 1989, AUTISM EXPLAINING EN
Gerry DW, 2010, DEVELOPMENTAL SCI, V13, P545, DOI 10.1111/j.1467-7687.2009.00912.x
Gomes E, 2004, ARQ NEURO-PSIQUIAT, V62, P797, DOI 10.1590/S0004-282X2004000500011
Gopnik A., 1999, SCI CRIB MINDS BRAIN
Griffiths TD, 2007, NEURON, V56, P580, DOI 10.1016/j.neuron.2007.11.004
Groen WB, 2009, J AUTISM DEV DISORD, V39, P742, DOI 10.1007/s10803-008-0682-3
Han LA, 1998, SCAND AUDIOL, V27, P105, DOI 10.1080/010503998420342
Hannon EE, 2005, PSYCHOL SCI, V16, P48, DOI 10.1111/j.0956-7976.2005.00779.x
Hannon EE, 2005, P NATL ACAD SCI USA, V102, P12639, DOI 10.1073/pnas.0504254102
Hannon EE, 2007, TRENDS COGN SCI, V11, P466, DOI 10.1016/j.tics.2007.08.008
Happe F, 2006, J AUTISM DEV DISORD, V36, P5, DOI 10.1007/s10803-005-0039-0
Heaton P, 2009, PHILOS T R SOC B, V364, P1443, DOI 10.1098/rstb.2008.0327
Heaton P, 2007, J AUTISM DEV DISORD, V37, P1355, DOI 10.1007/s10803-006-0283-y
Heaton P, 2008, COGN NEUROPSYCHOL, V25, P771, DOI 10.1080/02643290802336277
Heaton P, 1999, NEUROCASE, V5, P503, DOI 10.1080/13554799908402745
Herbert MR, 2002, ANN NEUROL, V52, P588, DOI 10.1002/ana.10349
Iarocci G, 2010, AUTISM, V14, P305, DOI 10.1177/1362361309353615
Iarocci G, 2006, J AUTISM DEV DISORD, V36, P77, DOI 10.1007/s10803-005-0044-3
Jarvinen-Pasley A, 2007, DEVELOPMENTAL SCI, V10, P786, DOI 10.1111/j.1467-7687.2007.00637.x
Just MA, 2007, CEREB CORTEX, V17, P951, DOI 10.1093/cercor/bhl006
Just MA, 2004, BRAIN, V127, P1811, DOI 10.1093/brain/awh199
Kawabe T, 2010, PLOS ONE, V5, P1
Kern JK, 2006, AUTISM, V10, P480, DOI 10.1177/1362361306066564
Kirschner S, 2009, J EXP CHILD PSYCHOL, V102, P299, DOI 10.1016/j.jecp.2008.07.005
Kirschner S, 2010, EVOL HUM BEHAV, V31, P354, DOI 10.1016/j.evolhumbehav.2010.04.004
Klin A, 2009, AUTISM RES, V2, P178
Kuhl PK, 2003, P NATL ACAD SCI USA, V100, P9096, DOI 10.1073/pnas.1532872100
Lane AE, 2010, J AUTISM DEV DISORD, V40, P112, DOI 10.1007/s10803-009-0840-2
Lepisto T, 2009, BIOL PSYCHOL, V82, P301, DOI 10.1016/j.biopsycho.2009.09.004
LORD C, 1989, J AUTISM DEV DISORD, V19, P185, DOI 10.1007/BF02211841
LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
Loui P, 2011, J COGNITIVE NEUROSCI, V23, P1015, DOI 10.1162/jocn.2010.21500
McAdams S, 1997, J ACOUST SOC AM, V102, P2945, DOI 10.1121/1.420349
MCGURK H, 1976, NATURE, V264, P746, DOI 10.1038/264746a0
McIntosh D. N., 1999, SENSORY PROFILE EXAM, P59
Mottron L, 1999, NEUROCASE, V5, P485, DOI 10.1080/13554799908402744
Neurobehavioral Systems, 2007, PRES 11 0
OSTERLING J, 1994, J AUTISM DEV DISORD, V24, P247, DOI 10.1007/BF02172225
Osterling JA, 2002, DEV PSYCHOPATHOL, V14, P239
Overy K, 2009, MUSIC PERCEPT, V26, P489, DOI 10.1525/MP.2009.26.5.489
Patel AD, 2009, CURR BIOL, V19, P827, DOI 10.1016/j.cub.2009.03.038
Peppe S, 2007, J SPEECH LANG HEAR R, V50, P1015, DOI 10.1044/1092-4388(2007/071)
Pfordresher PQ, 2009, MUSIC PERCEPT, V25, P95
Pierce K., 2010, ARCH GEN PSYCHIAT, V68, P101
Plaisted K, 1999, J CHILD PSYCHOL PSYC, V40, P733, DOI 10.1111/1469-7610.00489
Plantinga J, 2008, MUSIC PERCEPT, V26, P121, DOI 10.1525/MP.2008.26.2.121
Poulin-Charronnat B, 2005, COGNITION, V94, pB67, DOI 10.1016/j.cognition.2004.05.003
RATCLIFF R, 1993, PSYCHOL BULL, V114, P510, DOI 10.1037/0033-2909.114.3.510
RIMLAND B, 1995, J AUTISM DEV DISORD, V25, P61, DOI 10.1007/BF02178168
Rimland B, 1984, MENTAL RETARDATION D, P55
Rogers SJ, 2003, J AUTISM DEV DISORD, V33, P631, DOI 10.1023/B:JADD.0000006000.38991.a7
Roid G, 2005, LEITER INT PERFORMAN
Rosenblum LD, 1997, PERCEPT PSYCHOPHYS, V59, P347, DOI 10.3758/BF03211902
Rosenhall U, 1999, J AUTISM DEV DISORD, V29, P349, DOI 10.1023/A:1023022709710
Ross DA, 2004, J ACOUST SOC AM, V116, P1793, DOI 10.1121/1.1758973
Russo N, 2009, DEVELOPMENTAL SCI, V12, P557, DOI 10.1111/j.1467-7687.2008.00790.x
Russo N, 2009, J AUTISM DEV DISORD, V39, P1185, DOI 10.1007/s10803-009-0737-0
Rutherford MD, 2005, NEUROCASE, V11, P1
Schachner A, 2009, CURR BIOL, V19, P831, DOI 10.1016/j.cub.2009.03.061
Schellenberg EG, 2005, DEVELOPMENTAL SCI, V8, P551, DOI 10.1111/j.1467-7687.2005.00447.x
Schoen S.A., 2009, FRONTIERS INTEGRATIV, V3, P1, DOI DOI 10.3389/NEURO.07.029.2009
Schultz RT, 2000, ARCH GEN PSYCHIAT, V57, P331, DOI 10.1001/archpsyc.57.4.331
SHAH A, 1983, J CHILD PSYCHOL PSYC, V24, P613, DOI 10.1111/j.1469-7610.1983.tb00137.x
Simpson K, 2010, J DEV PHYS DISABIL, V22, P165, DOI 10.1007/s10882-009-9173-5
Skukla DK, 2010, J CHILD PSYCHOL PSYC, V52, P286
Smith EG, 2007, J CHILD PSYCHOL PSYC, V48, P813, DOI 10.1111/j.1469-7610.2007.01766.x
Smith NA, 2011, INFANCY, V16, P1
Sussman E, 2007, HEARING RES, V225, P117, DOI 10.1016/j.heares.2006.12.013
Teder-Salejarvi WA, 2005, COGNITIVE BRAIN RES, V23, P221, DOI 10.1016/j.cogbrainres.2004.10.021
Tillmann B, 2007, COGNITIVE NEUROPSYCH, V24, P1
Tillmann B, 2006, EUR J COGN PSYCHOL, V18, P343, DOI 10.1080/09541440500269548
Trainor LJ, 2010, SPRINGER HANDB AUDIT, V36, P89, DOI 10.1007/978-1-4419-6114-3_4
TRAINOR LJ, 1994, PERCEPT PSYCHOPHYS, V56, P125, DOI 10.3758/BF03213891
TRAINOR LJ, 1992, J EXP PSYCHOL HUMAN, V18, P394, DOI 10.1037//0096-1523.18.2.394
Trehub SE, 2009, CORTEX, V45, P110, DOI 10.1016/j.cortex.2008.05.012
Trehub SE, 2001, ANN NY ACAD SCI, V930, P1
TREHUB SE, 1984, CHILD DEV, V55, P821, DOI 10.1111/j.1467-8624.1984.tb03819.x
Tucker-Davis Technologies, 2007, PROGR ATT
Wan C. Y., 2010, FUTURE NEUROL, V5, P797, DOI 10.2217/fnl.10.55
Wan CY, 2010, BRAIN RES BULL, V82, P161, DOI 10.1016/j.brainresbull.2010.04.010
WATSON AB, 1983, PERCEPT PSYCHOPHYS, V33, P113, DOI 10.3758/BF03202828
Wechsler DA, 1997, DIGIT SPAN SUBTEST W
Werker JF, 2005, DEV PSYCHOBIOL, V46, P233, DOI 10.1002/dev.20060
WERKER JF, 1988, DEV PSYCHOL, V24, P672, DOI 10.1037//0012-1649.24.5.672
Werner E, 2000, J AUTISM DEV DISORD, V30, P157, DOI 10.1023/A:1005463707029
Willeford J.A., 1977, CENTRAL AUDITORY DYS, P43
Williams JHG, 2004, RES DEV DISABIL, V25, P559, DOI 10.1016/j.ridd.2004.01.008
Winkler I, 2003, P NATL ACAD SCI USA, V100, P11812, DOI 10.1073/pnas.2031891100
YOUNG RL, 1995, J AUTISM DEV DISORD, V25, P231, DOI 10.1007/BF02179286
Zwaigenbaum L, 2009, PEDIATRICS, V123, P1383, DOI 10.1542/peds.2008-1606
NR 130
TC 14
Z9 14
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD SEP 12
PY 2012
VL 7
IS 9
AR e44084
DI 10.1371/journal.pone.0044084
PG 17
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 005GJ
UT WOS:000308738500029
PM 22984462
ER
PT J
AU Ginsberg, MR
Rubin, RA
Falcone, T
Ting, AH
Natowicz, MR
AF Ginsberg, Matthew R.
Rubin, Robert A.
Falcone, Tatiana
Ting, Angela H.
Natowicz, Marvin R.
TI Brain Transcriptional and Epigenetic Associations with Autism
SO PLOS ONE
LA English
DT Article
ID COPY-NUMBER VARIATION; DE-NOVO MUTATIONS; SPECTRUM DISORDERS;
GENE-EXPRESSION; CHILDREN; NETWORK; GENOME; PATHOPHYSIOLOGY;
DYSFUNCTION; VARIANTS
AB Background: Autism is a common neurodevelopmental syndrome. Numerous rare genetic etiologies are reported; most cases are idiopathic.
Methodology/Principal Findings: To uncover important gene dysregulation in autism we analyzed carefully selected idiopathic autistic and control cerebellar and BA19 (occipital) brain tissues using high resolution whole genome gene expression and whole genome DNA methylation microarrays. No changes in DNA methylation were identified in autistic brain but gene expression abnormalities in two areas of metabolism were apparent: down-regulation of genes of mitochondrial oxidative phosphorylation and of protein translation. We also found associations between specific behavioral domains of autism and specific brain gene expression modules related to myelin/myelination, inflammation/immune response and purinergic signaling.
Conclusions/Significance: This work highlights two largely unrecognized molecular pathophysiological themes in autism and suggests differing molecular bases for autism behavioral endophenotypes.
C1 [Ginsberg, Matthew R.; Natowicz, Marvin R.] Cleveland Clin, Lerner Coll Med, Cleveland, OH 44106 USA.
[Rubin, Robert A.] Whittier Coll, Dept Math, Whittier, CA USA.
[Falcone, Tatiana; Natowicz, Marvin R.] Cleveland Clin, Neurol Inst, Cleveland, OH 44106 USA.
[Ting, Angela H.; Natowicz, Marvin R.] Cleveland Clin, Genom Med Inst, Cleveland, OH 44106 USA.
[Natowicz, Marvin R.] Cleveland Clin, Pathol & Lab Med Inst, Cleveland, OH 44106 USA.
[Natowicz, Marvin R.] Cleveland Clin, Inst Pediat, Cleveland, OH 44106 USA.
RP Ginsberg, MR (reprint author), Cleveland Clin, Lerner Coll Med, Cleveland, OH 44106 USA.
EM natowim@ccf.org
FU Cleveland Clinic Research Program Committee; Autism Research Institute
FX This work was supported by grants from the Cleveland Clinic Research
Program Committee and the Autism Research Institute (www.autism.com/).
The funders had no role in study design, data collection and analysis,
decision to publish, or preparation of the manuscript.
CR Anagnostou E, 2011, MOL AUTISM, V2, DOI 10.1186/2040-2392-2-4
Auerbach BD, 2011, NATURE, V480, P63, DOI 10.1038/nature10658
Betancur C, 2011, BRAIN RES, V1380, P42, DOI 10.1016/j.brainres.2010.11.078
Burnstock G, 2011, CURR TOP MED CHEM, V11, P973
Chahrour MH, 2012, PLOS GENET, V8, P236, DOI 10.1371/journal.pgen.1002635
Chauhan A, 2011, J NEUROCHEM, V117, P209, DOI 10.1111/j.1471-4159.2011.07189.x
Cheung C, 2009, J CHILD PSYCHOL PSYC, V50, P1102, DOI 10.1111/j.1469-7610.2009.02086.x
Darnell JC, 2011, CURR OPIN GENET DEV, V21, P465, DOI 10.1016/j.gde.2011.05.002
Devlin B, 2012, CURR OPIN GENE DEV, V22, P1
Fatemi SH, 2012, CEREBELLUM, V11, P777, DOI 10.1007/s12311-012-0355-9
Filipovic-Sadic S, 2010, CLIN CHEM, V56, P399, DOI 10.1373/clinchem.2009.136101
Garbett K, 2008, NEUROBIOL DIS, V30, P303, DOI 10.1016/j.nbd.2008.01.012
Geschwind DH, 2011, TRENDS COGN SCI, V15, P409, DOI 10.1016/j.tics.2011.07.003
Gillis RF, 2011, MOL AUTISM, V2, DOI 10.1186/2040-2392-2-12
Gilman SR, 2011, NEURON, V70, P898, DOI 10.1016/j.neuron.2011.05.021
Giulivi C, 2010, JAMA-J AM MED ASSOC, V304, P2389, DOI 10.1001/jama.2010.1706
Glessner JT, 2009, NATURE, V459, P569, DOI 10.1038/nature07953
Gregg JP, 2008, GENOMICS, V91, P22, DOI 10.1016/j.ygeno.2007.09.003
Gregory SG, 2009, BMC MED, V7, DOI 10.1186/1741-7015-7-62
Haas RH, 2010, DEV DISABIL RES REV, V16, P144, DOI 10.1002/ddrr.112
Hazlett EA, 2004, NEUROPSYCHOBIOLOGY, V49, P115, DOI 10.1159/000076719
Iossifov I, 2012, NEURON, V74, P285, DOI 10.1016/j.neuron.2012.04.009
Jiang YH, 2004, AM J MED GENET A, V131A, P1, DOI 10.1002/ajmg.a.30297
Langfelder P, 2008, BMC BIOINFORMATICS, V9, DOI 10.1186/1471-2105-9-559
Levitt P, 2009, J CLIN INVEST, V119, P747, DOI 10.1172/JCI37934
Levy D, 2011, NEURON, V70, P886, DOI 10.1016/j.neuron.2011.05.015
Levy SE, 2009, LANCET, V374, P1627, DOI 10.1016/S0140-6736(09)61376-3
Nagarajan RP, 2008, AUTISM RES, V1, P169, DOI 10.1002/aur.24
Neale BM, 2012, NATURE, V485, P242, DOI 10.1038/nature11011
Nguyen A, 2010, FASEB J, V24, P3036, DOI [10.1096/fj.10-154484, 10.1096/fj.09-154484]
Onore C, 2012, BRAIN BEHAV IMMUN, V26, P383, DOI 10.1016/j.bbi.2011.08.007
O'Roak BJ, 2012, NATURE, V485, P246, DOI 10.1038/nature10989
Pinto D, 2010, NATURE, V466, P368, DOI 10.1038/nature09146
Ring HA, 1999, BRAIN, V122, P1305, DOI 10.1093/brain/122.7.1305
Sakai Y, 2011, SCI TRANSL MED, V3, P1
Sanders SJ, 2012, NATURE, V485, P237, DOI 10.1038/nature10945
Sbacchi S, 2010, CURR GENOMICS, V11, P136, DOI 10.2174/138920210790886880
Voineagu I, 2011, NATURE, V474, P380, DOI 10.1038/nature10110
Voineagu I, 2012, NEUROBIOL DIS, V45, P69, DOI 10.1016/j.nbd.2011.07.017
Wintle RF, 2011, AUTISM RES, V4, P89, DOI 10.1002/aur.173
Xin YR, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0011357
Xu HC, 2011, BMC GENOMICS, V12, DOI 10.1186/1471-2164-12-499
Xu LM, 2012, NUCLEIC ACIDS RES, V40, pD1016, DOI 10.1093/nar/gkr1145
NR 43
TC 20
Z9 20
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD SEP 12
PY 2012
VL 7
IS 9
AR e44736
DI 10.1371/journal.pone.0044736
PG 9
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 005GJ
UT WOS:000308738500077
PM 22984548
ER
PT J
AU Zhong, XF
Li, HD
Chang, Q
AF Zhong, Xiaofen
Li, Hongda
Chang, Qiang
TI MeCP2 Phosphorylation Is Required for Modulating Synaptic Scaling
through mGluR5
SO JOURNAL OF NEUROSCIENCE
LA English
DT Article
ID CPG-BINDING PROTEIN-2; TRANSCRIPTIONAL REPRESSOR; HISTONE DEACETYLASE;
BDNF TRANSCRIPTION; METHYLATED DNA; RETT-SYNDROME; CHROMATIN; NEURONS;
EXPRESSION; RECEPTORS
AB MeCP2 (methyl CpG binding protein 2) is a key player in recognizing methylated DNA and interpreting the epigenetic information encoded in different DNA methylation patterns. The functional significance of MeCP2 to the mammalian nervous system is highlighted by the discovery that mutations in the MECP2 gene cause Rett syndrome (RTT), a devastating neurological disease that shares many features with autism. Synaptic scaling is a form of non-Hebbian homeostatic plasticity that allows neurons to regulate overall excitability in response to changes in network neuronal activity levels. While it is known that neuronal activity can induce phosphorylation of MeCP2 and that MeCP2 can regulate synaptic scaling, the molecular link between MeCP2 phosphorylation and synaptic scaling remains undefined. We show here that MeCP2 phosphorylation is specifically required for bicuculline-induced synaptic scaling down in mouse hippocampal neurons and this phenotype is mediated by mGluR5 (metabotropic glutamate receptor 5). Our results reveal an important function of MeCP2 in regulating neuronal homeostasis and may eventually help us understand how MECP2 mutations cause RTT.
C1 [Zhong, Xiaofen; Li, Hongda; Chang, Qiang] Univ Wisconsin, Waisman Ctr, Madison, WI 53705 USA.
[Chang, Qiang] Univ Wisconsin, Dept Med Genet, Madison, WI 53705 USA.
[Chang, Qiang] Univ Wisconsin, Dept Neurol, Madison, WI 53705 USA.
[Li, Hongda; Chang, Qiang] Univ Wisconsin, Genet Training Program, Madison, WI 53706 USA.
RP Chang, Q (reprint author), 1500 Highland Ave, Madison, WI 53705 USA.
EM qchang@waisman.wisc.edu
FU NIH-NICHD [R01 HD064743, P30 HD03352]; Stem Cell and Regenerative
Medicine Center at the University of Wisconsin-Madison
FX This work was supported by NIH-NICHD Grants R01 HD064743 to Q. C. and
P30 HD03352 to the Waisman Center. H. L. was supported by a pre-doctoral
fellowship from the Stem Cell and Regenerative Medicine Center at the
University of Wisconsin-Madison. We thank Fei Yu for technical support.
CR Amir RE, 1999, NAT GENET, V23, P185
Ayala R, 2012, J NEUROSCI METH, V204, P221, DOI 10.1016/j.jneumeth.2011.11.014
Chahrour M, 2008, SCIENCE, V320, P1224, DOI 10.1126/science.1153252
Chen WG, 2003, SCIENCE, V302, P885, DOI 10.1126/science.1086446
Cohen S, 2011, NEURON, V72, P72, DOI 10.1016/j.neuron.2011.08.022
Deng JV, 2010, NAT NEUROSCI, V13, P1128, DOI 10.1038/nn.2614
Gascon S, 2008, J NEUROSCI METH, V168, P104, DOI 10.1016/j.jneumeth.2007.09.023
Geranton SM, 2008, MOL PAIN, V4, DOI 10.1186/1744-8069-4-35
Geranton SM, 2007, J NEUROSCI, V27, P6163, DOI 10.1523/JNEUROSCI.1306-07.2007
Gonzales ML, 2012, MOL CELL BIOL, V32, P2894, DOI 10.1128/MCB.06728-11
HAGBERG B, 1985, ACTA PAEDIATR SCAND, V74, P405, DOI 10.1111/j.1651-2227.1985.tb10993.x
Hu JH, 2010, NEURON, V68, P1128, DOI 10.1016/j.neuron.2010.11.008
Jones PL, 1998, NAT GENET, V19, P187, DOI 10.1038/561
LEWIS JD, 1992, CELL, V69, P905, DOI 10.1016/0092-8674(92)90610-O
Li HD, 2011, NAT NEUROSCI, V14, P1001, DOI 10.1038/nn.2866
Mao LM, 2011, NEUROCHEM INT, V59, P610, DOI 10.1016/j.neuint.2011.04.013
Murgatroyd C, 2009, NAT NEUROSCI, V12, P1559, DOI 10.1038/nn.2436
Nan XS, 1997, CELL, V88, P471, DOI 10.1016/S0092-8674(00)81887-5
Nan XS, 1998, NATURE, V393, P386
Qiu ZL, 2012, J NEUROSCI, V32, P989, DOI 10.1523/JNEUROSCI.0175-11.2012
Shepherd JD, 2006, NEURON, V52, P475, DOI 10.1016/j.neuron.2006.08.034
Skene PJ, 2010, MOL CELL, V37, P457, DOI 10.1016/j.molcel.2010.01.030
Tao JF, 2009, P NATL ACAD SCI USA, V106, P4882, DOI 10.1073/pnas.0811648106
Turrigiano GG, 1998, NATURE, V391, P892, DOI 10.1038/36103
Zhou ZL, 2006, NEURON, V52, P255, DOI 10.1016/j.neuron.2006.09.037
NR 25
TC 18
Z9 20
PU SOC NEUROSCIENCE
PI WASHINGTON
PA 11 DUPONT CIRCLE, NW, STE 500, WASHINGTON, DC 20036 USA
SN 0270-6474
J9 J NEUROSCI
JI J. Neurosci.
PD SEP 12
PY 2012
VL 32
IS 37
BP 12841
EP 12847
DI 10.1523/JNEUROSCI.2784-12.2012
PG 7
WC Neurosciences
SC Neurosciences & Neurology
GA 006FV
UT WOS:000308805800019
PM 22973007
ER
PT J
AU Roy, S
Watkins, N
Heck, D
AF Roy, Snigdha
Watkins, Nick
Heck, Detlef
TI Comprehensive Analysis of Ultrasonic Vocalizations in a Mouse Model of
Fragile X Syndrome Reveals Limited, Call Type Specific Deficits
SO PLOS ONE
LA English
DT Article
ID UNUSUAL REPERTOIRE; MATERNAL-BEHAVIOR; YOUNG MALES; RAT PUPS; AUTISM;
MICE; LANGUAGE; TF/J; COMMUNICATION; DISORDERS
AB Fragile X syndrome (FXS) is a well-recognized form of inherited mental retardation, caused by a mutation in the fragile X mental retardation 1 (Fmr1) gene. The gene is located on the long arm of the X chromosome and encodes fragile X mental retardation protein (FMRP). Absence of FMRP in fragile X patients as well as in Fmr1 knockout (KO) mice results, among other changes, in abnormal dendritic spine formation and altered synaptic plasticity in the neocortex and hippocampus. Clinical features of FXS include cognitive impairment, anxiety, abnormal social interaction, mental retardation, motor coordination and speech articulation deficits. Mouse pups generate ultrasonic vocalizations (USVs) when isolated from their mothers. Whether those social ultrasonic vocalizations are deficient in mouse models of FXS is unknown. Here we compared isolation-induced USVs generated by pups of Fmr1-KO mice with those of their wild type (WT) littermates. Though the total number of calls was not significantly different between genotypes, a detailed analysis of 10 different categories of calls revealed that loss of Fmr1 expression in mice causes limited and call-type specific deficits in ultrasonic vocalization: the carrier frequency of flat calls was higher, the percentage of downward calls was lower and that the frequency range of complex calls was wider in Fmr1-KO mice compared to their WT littermates.
C1 [Roy, Snigdha; Heck, Detlef] Univ Tennessee, Ctr Hlth Sci, Dept Anat & Neurobiol, Memphis, TN 38163 USA.
[Watkins, Nick] Christian Bros Univ, Dept Biol, Memphis, TN USA.
RP Roy, S (reprint author), Univ Tennessee, Ctr Hlth Sci, Dept Anat & Neurobiol, Memphis, TN 38163 USA.
EM sroy3@uthsc.edu
FU National Institutes of Health [R01NS063009, R01NS060887]
FX This work was supported by grants from the National Institutes of Health
to D. H. H. (R01NS063009 and R01NS060887). The funders had no role in
study design, data collection and analysis, decision to publish, or
preparation of the manuscript.
CR Abbeduto L, 2007, MENT RETARD DEV D R, V13, P36, DOI 10.1002/mrdd.20142
Abrahams BS, 2008, NAT REV GENET, V9, P341, DOI 10.1038/nrg2346
Barnes EF, 2006, J SPEECH LANG HEAR R, V49, P903, DOI 10.1044/1092-4388(2006/065)
BROUETTELAHLOU I, 1992, BEHAV BRAIN RES, V50, P147, DOI 10.1016/S0166-4328(05)80296-7
Brudzynski SM, 1999, DEV PSYCHOBIOL, V34, P195, DOI 10.1002/(SICI)1098-2302(199904)34:3<195::AID-DEV4>3.0.CO;2-S
BRUNELLI SA, 1994, J COMP PSYCHOL, V108, P298, DOI 10.1037//0735-7036.108.3.298
Bryant JL, 2010, EUR J NEUROSCI, V32, P41, DOI 10.1111/j.1460-9568.2010.07244.x
Crawford DC, 2001, GENET MED, V3, P359, DOI 10.1097/00125817-200109000-00006
EHRET G, 1992, ANIM BEHAV, V43, P409, DOI 10.1016/S0003-3472(05)80101-0
EHRET G, 1986, ANIM BEHAV, V34, P821, DOI 10.1016/S0003-3472(86)80067-7
Ellegood J, 2010, NEUROIMAGE, V53, P1023, DOI 10.1016/j.neuroimage.2010.03.038
Farrell WJ, 2002, J COMP PSYCHOL, V116, P297, DOI 10.1037//0735-7036.116.3.297
Fujita E, 2008, P NATL ACAD SCI USA, V105, P3117, DOI 10.1073/pnas.0712298105
Gordon N, 1996, EUR J DISORDER COMM, V31, P359
Hagerman R, 2010, MOL AUTISM, V1, DOI 10.1186/2040-2392-1-12
Hahn ME, 2005, BEHAV GENET, V35, P31, DOI 10.1007/s10519-004-0854-7
Harris SW, 2008, AM J MENT RETARD, V113, P427, DOI 10.1352/2008.113:427-438
Heck DH, 2008, HUM MOL GENET, V17, P2181, DOI 10.1093/hmg/ddn117
LOESCH DZ, 1988, J MED GENET, V25, P407, DOI 10.1136/jmg.25.6.407
MADISON LS, 1986, J MENT DEFIC RES, V30, P129
Mostofsky SH, 1998, NEUROLOGY, V50, P121
Newell K, 1983, FRAGILE X SYNDROME D, P175
PAUL R, 1987, J AUTISM DEV DISORD, V17, P457, DOI 10.1007/BF01486963
Persico AM, 2006, TRENDS NEUROSCI, V29, P349, DOI 10.1016/j.tins.2006.05.010
REISS AL, 1991, ANN NEUROL, V29, P26, DOI 10.1002/ana.410290107
Rogers SJ, 2001, J DEV BEHAV PEDIATR, V22, P409
Roy S, 2011, BEHAV NEUROSCI, V125, P962, DOI 10.1037/a0025920
Scattoni ML, 2008, PLOS ONE, V3, DOI 10.1371/journal.pone.0003067
Scattoni ML, 2009, NEUROSCI BIOBEHAV R, V33, P508, DOI 10.1016/j.neubiorev.2008.08.003
Scattoni ML, 2011, GENES BRAIN BEHAV, V10, P44, DOI 10.1111/j.1601-183X.2010.00623.x
Shair HN, 2007, BEHAV BRAIN RES, V182, P180, DOI 10.1016/j.bbr.2007.02.016
SHAMBES GM, 1978, BRAIN BEHAV EVOLUT, V15, P94, DOI 10.1159/000123774
SMITH JC, 1976, J COMP PHYSIOL PSYCH, V90, P1105, DOI 10.1037/h0077287
WELSH JP, 1995, NATURE, V374, P453, DOI 10.1038/374453a0
Wohr M, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0020631
Wohr M, 2011, GENES BRAIN BEHAV, V10, P35, DOI 10.1111/j.1601-183X.2010.00582.x
Yang M, 2007, FRONT BEHAV NEUROSCI, V1, DOI [10.3389/neuro.08.001.2007, 10.3389/neuro.08/001.2007]
Young DM, 2010, P NATL ACAD SCI USA, V107, P11074, DOI 10.1073/pnas.1005620107
Zajac DJ, 2006, J SPEECH LANG HEAR R, V49, P1147, DOI 10.1044/1092-4388(2006/082)
ZESKIND PS, 1988, CHILD DEV, V59, P193
Zingerevich C, 2009, J INTELL DISABIL RES, V53, P11, DOI 10.1111/j.1365-2788.2008.01107.x
NR 41
TC 11
Z9 11
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD SEP 11
PY 2012
VL 7
IS 9
AR e44816
DI 10.1371/journal.pone.0044816
PG 6
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 003VE
UT WOS:000308638700087
PM 22984567
ER
PT J
AU van Balkom, IDC
Bresnahan, M
Vuijk, PJ
Hubert, J
Susser, E
Hoek, HW
AF van Balkom, Ingrid D. C.
Bresnahan, Michaeline
Vuijk, Pieter Jelle
Hubert, Jan
Susser, Ezra
Hoek, Hans W.
TI Paternal Age and Risk of Autism in an Ethnically Diverse,
Non-Industrialized Setting: Aruba
SO PLOS ONE
LA English
DT Article
ID SPECTRUM DISORDERS; PERINATAL FACTORS; BIRTH-WEIGHT; POPULATION;
PRETERM; TRAITS
AB Objective: The aim of this study was to examine paternal age in relation to risk of autism spectrum disorders (ASDs) in a setting other than the industrialized west.
Design: A case-control study of Aruban-born children (1990-2003). Cases (N = 95) were identified at the Child and Adolescent Psychiatry Clinic, the only such clinic in Aruba; gender and age matched controls (N = 347) were gathered from public health records. Parental age was defined categorically (<= 29, 30-39, 40-49, >= 50y). The analysis was made, using conditional logistic regression.
Results: Advanced paternal age was associated with increased risk of ASDs in offspring. In comparison to the youngest paternal age group (<= 29y), risk of autism increased 2.18 times for children born from fathers in their thirties, 2.71 times for fathers in their forties, and 3.22 thereafter.
Conclusion: This study, part of the first epidemiologic study of autism in the Caribbean, contributes additional evidence, from a distinctive sociocultural setting, of the risk of ASD associated with increased paternal age.
C1 [van Balkom, Ingrid D. C.] Lentis Psychiat Inst, Jonx Dept Youth Mental Hlth, Groningen, Netherlands.
[van Balkom, Ingrid D. C.] Univ Groningen, Univ Med Ctr Groningen, Dept Psychiat, Rob Giel Res Ctr, Groningen, Netherlands.
[Bresnahan, Michaeline; Susser, Ezra; Hoek, Hans W.] Columbia Univ, Mailman Sch Publ Hlth, New York, NY USA.
[Bresnahan, Michaeline; Susser, Ezra] New York State Psychiat Inst & Hosp, New York, NY 10032 USA.
[Vuijk, Pieter Jelle] Vrije Univ Amsterdam, Dept Clin Neuropsychol, Amsterdam, Netherlands.
[Susser, Ezra] Columbia Univ Coll Phys & Surg, New York, NY 10032 USA.
[Hoek, Hans W.] Parnassia Bavo Psychiat Inst, The Hague, Netherlands.
EM idc.vanbalkom@lentis.nl
CR Alter MD, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0016715
Bailey A, 1998, J AUTISM DEV DISORD, V28, P369, DOI 10.1023/A:1026048320785
Bongaarts J, 2003, POP STUD-J DEMOG, V57, P321, DOI 10.1080/003247203200013785
Buchmayer S, 2009, PEDIATRICS, V124, pE817, DOI 10.1542/peds.2008-3582
Buizer-Voskamp JE, 2011, SCHIZOPHR RES, V129, P128, DOI 10.1016/j.schres.2011.03.021
Buwe A, 2005, CYTOGENET GENOME RES, V111, P213, DOI 10.1159/000086892
Central Bureau of Statistics (CBS), 2002, CENS 2000 SPEC REP
Charman T, 2005, J AUTISM DEV DISORD, V35, P539, DOI 10.1007/s10803-005-5068-1
Cheslack-Postava K, 2011, PEDIATRICS, V127, P246, DOI 10.1542/peds.2010-2371
Constantino JN, 2005, BIOL PSYCHIAT, V57, P655, DOI 10.1016/j.biopsych.2004.12.014
Croen LA, 2007, ARCH PEDIAT ADOL MED, V161, P334, DOI 10.1001/archpedi.161.4.334
Crow JF, 2000, NAT REV GENET, V1, P40, DOI 10.1038/35049558
Flanagan JM, 2006, AM J HUM GENET, V79, P67, DOI 10.1086/504729
Glasson EJ, 2004, ARCH GEN PSYCHIAT, V61, P618, DOI 10.1001/archpsyc.61.6.618
Grether JK, 2009, AM J EPIDEMIOL, V170, P1118, DOI 10.1093/aje/kwp247
Hultman CM, 2011, MOL PSYCHIATR, V16, P1203, DOI 10.1038/mp.2010.121
Larsson HJ, 2005, AM J EPIDEMIOL, V161, P916, DOI 10.1093/aje/kwi123
Lauritsen MB, 2005, J CHILD PSYCHOL PSYC, V46, P963, DOI 10.1111/j.1469-7610.2004.00391.x
Leonard H, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0017875
Parner ET, 2012, ANN EPIDEMIOL, V22, P143, DOI 10.1016/j.annepidem.2011.12.006
Puleo CM, 2008, MOL PSYCHIATR, V13, P243, DOI 10.1038/sj.mp.4002102
Reichenberg A, 2006, ARCH GEN PSYCHIAT, V63, P1026, DOI 10.1001/archpsyc.63.9.1026
Sasanfar R, 2010, MOL AUTISM, V1, DOI 10.1186/2040-2392-1-2
Sebat J, 2007, SCIENCE, V316, P445, DOI 10.1126/science.1138659
Shah PS, 2010, AM J OBSTET GYNECOL, V202, P103, DOI 10.1016/j.ajog.2009.08.026
Shelton JF, 2010, AUTISM RES, V3, P30, DOI 10.1002/aur.116
Toro-Labrador G, 2003, CARIBB J SCI, V39, P11
Tough SC, 2002, PEDIATRICS, V109, P399, DOI 10.1542/peds.109.3.399
van Balkom IDC, 2009, J NEURODEV DISORD, V1, P197, DOI 10.1007/s11689-009-9011-1
Zhang X, 2010, J AUTISM DEV DISORD, V40, P1311, DOI 10.1007/s10803-010-0992-0
NR 30
TC 8
Z9 8
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD SEP 11
PY 2012
VL 7
IS 9
AR e45090
DI 10.1371/journal.pone.0045090
PG 4
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 003VE
UT WOS:000308638700108
PM 22984615
ER
PT J
AU Drahota, A
Aarons, GA
Stahmer, AC
AF Drahota, Amy
Aarons, Gregory A.
Stahmer, Aubyn C.
TI Developing the Autism Model of Implementation for Autism spectrum
disorder community providers: study protocol
SO IMPLEMENTATION SCIENCE
LA English
DT Article
DE Autism spectrum disorder; Evidence-based practice; Implementation;
Organization; Community provider; Model development
ID COGNITIVE-BEHAVIORAL THERAPY; HEALTH-SERVICES RESEARCH; HIGH-FUNCTIONING
AUTISM; CONTROLLED-TRIAL; PREVENTION RESEARCH; ANXIETY DISORDERS;
ASPERGER-SYNDROME; STAFF TURNOVER; YOUNG-CHILDREN; PDD-NOS
AB Background: Currently, 1 out of 88 children are diagnosed with an autism spectrum disorder (ASD), and the estimated cost for treatment services is $126 billion annually. Typically, ASD community providers (ASD-CPs) provide services to children with any severity of ASD symptoms using a combination of various treatment paradigms, some with an evidence-base and some without. When evidence-based practices (EBPs) are successfully implemented by ASD-CPs, they can result in positive outcomes. Despite this promise, EBPs are often implemented unsuccessfully and other treatments used by ASD-CPs lack supportive evidence, especially for school-age children with ASD. While it is not well understood why ASD-CPs are not implementing EBPs, organizational and individual characteristics likely play a role. As a response to this need and to improve the lives of children with ASD and their families, this study aims to develop and test the feasibility and acceptability of the Autism Model of Implementation (AMI) to support the implementation of EBPs by ASD-CPs.
Methods/design: An academic-community collaboration developed to partner with ASD-CPs will facilitate the development of the AMI, a process specifically for use by ASD community-based agencies. Using a mixed methods approach, the project will assess agency and individual factors likely to facilitate or hinder implementing EBPs in this context; develop the AMI to address identified barriers and facilitators; and pilot test the AMI to examine its feasibility and acceptability using a specific EBP to treat anxiety disorders in school-age children with ASD.
Discussion: The AMI will represent a data-informed approach to facilitate implementation of EBPs by ASD-CPs by providing an implementation model specifically developed for this context. This study is designed to address the real-world implications of EBP implementation in ASD community-based agencies. In doing so, the AMI will help to provide children with ASD the best and most effective services in their own community. Moreover, the proposed study will positively impact the field of implementation science by providing an empirically supported and tested model of implementation to facilitate the identification, adoption, and use of EBPs.
C1 [Drahota, Amy] San Diego State Univ, Dept Psychol, San Diego, CA 92182 USA.
[Drahota, Amy; Aarons, Gregory A.; Stahmer, Aubyn C.] Rady Childrens Hosp, Child & Adolescent Serv Res Ctr, San Diego, CA USA.
[Aarons, Gregory A.; Stahmer, Aubyn C.] Univ Calif San Diego, Dept Psychiat, La Jolla, CA 92093 USA.
RP Drahota, A (reprint author), San Diego State Univ, Dept Psychol, San Diego, CA 92182 USA.
EM adrahota@casrc.org
FU National Institute of Mental Health grant [K01MH093477]
FX This study is supported by the National Institute of Mental Health grant
K01MH093477 (Principal investigator: Amy Drahota).
CR Aarons GA, 2006, ADM POLICY MENT HLTH, V33, P289, DOI 10.1007/s10488-006-0039-1
Aarons GA, 2011, ADM POLICY MENT HLTH, V38, P4, DOI 10.1007/s10488-010-0327-7
Aarons GA, 2007, ADM POLICY MENT HLTH, V34, P465, DOI 10.1007/s10488-007-0127-x
Aarons Gregory A, 2004, Ment Health Serv Res, V6, P61, DOI 10.1023/B:MHSR.0000024351.12294.65
Aarons GA, 2009, J CONSULT CLIN PSYCH, V77, P270, DOI 10.1037/a0013223
ALTMAN DG, 1995, HEALTH PSYCHOL, V14, P526, DOI 10.1037/0278-6133.14.6.526
Baker EA, 1999, AM J PREV MED, V16, P86, DOI 10.1016/S0749-3797(98)00149-4
Bellini S., 2004, FOCUS AUTISM OTHER D, V19, P78, DOI DOI 10.1177/10883576040190020201
Brookman-Frazee L, 2009, J MENT HEALTH RES IN, V2, P201, DOI 10.1080/19315860902741542
Brookman-Frazee L, 2009, ADM POLICY MENT HLTH, V36, P1, DOI 10.1007/s10488-008-0195-6
Brookman-Frazee LI, 2010, J AUTISM DEV DISORD, V40, P1188, DOI 10.1007/s10803-010-0976-0
California Health and Human Services Agency, 2008, AUT SPECTR DIS CHANG
Chalfant AM, 2007, J AUTISM DEV DISORD, V37, P1842, DOI 10.1007/s10803-006-0318-4
Chamberlain P, 2011, IMPLEMENT SCI, V6, DOI 10.1186/1748-5908-6-116
Chorpita BE, 2003, EVIDENCE-BASED PSYCHOTHERAPIES FOR CHILDREN AND ADOLESCENTS, P42
Creswell JW, 2006, PLANO CLARK VL DESIG
Damschroder LJ, 2009, IMPLEMENT SCI, V4, DOI 10.1186/1748-5908-4-50
de Bruin EI, 2007, J AUTISM DEV DISORD, V37, P877, DOI 10.1007/s10803-006-0215-x
Drahota A, 2011, J AUTISM DEV DISORD, V41, P257, DOI 10.1007/s10803-010-1037-4
Fox J, 2011, R COMPANION APPL REG
Glaser B., 1967, DISCOVERY GROUNDED T
Glisson C, 2002, J ORGAN BEHAV, V23, P767, DOI 10.1002/job.162
Glisson Charles, 2005, Ment Health Serv Res, V7, P243, DOI 10.1007/s11020-005-7456-1
Greenhalgh T, 2004, MILBANK Q, V82, P581, DOI 10.1111/j.0887-378X.2004.00325.x
Israel BA, 1998, ANNU REV PUBL HEALTH, V19, P173, DOI 10.1146/annurev.publhealth.19.1.173
Jones L, 2007, JAMA-J AM MED ASSOC, V297, P407, DOI 10.1001/jama.297.4.407
Klin A, 2005, J AUTISM DEV DISORD, V35, P221, DOI 10.1007/s10803-005-2001-6
Knapp M, 2012, AUTISM SUMMIT INVEST
Lasker RD, 2001, MILBANK Q, V79, P179, DOI 10.1111/1468-0009.00203
Mandlawitz MR, 2002, J AUTISM DEV DISORD, V32, P495, DOI 10.1023/A:1020502324718
Matson JL, 2008, RES AUTISM SPECT DIS, V2, P60, DOI 10.1016/j.rasd.2007.03.003
Matson JL, 2007, RES DEV DISABIL, V28, P341, DOI 10.1016/j.ridd.2005.12.004
Mendel P, 2008, ADM POLICY MENT HLTH, V35, P21, DOI 10.1007/s10488-007-0144-9
Merzel Cheryl, 2007, Health Promot Pract, V8, P375, DOI 10.1177/1524839906289557
Mills R., 2005, RES INTERVENTIONS AS
Morgan DL, 1998, QUAL HEALTH RES, V8, P362, DOI 10.1177/104973239800800307
Morgan DL, 1992, TOOLS PRIMARY CARE R, P177
Muris P, 1998, J ANXIETY DISORD, V12, P387, DOI 10.1016/S0887-6185(98)00022-X
National Institute of Mental Health, 2008, STRAT PLAN
Parkinson G., 2006, J RES SPECIAL ED NEE, V6, P76, DOI 10.1111/j.1471-3802.2006.00062.x
Rogers SJ, 2008, J CLIN CHILD ADOLESC, V37, P8, DOI 10.1080/15374410701817808
Sofronoff K, 2005, J CHILD PSYCHOL PSYC, V46, P1152, DOI 10.1111/j.1469-7610.2005.00411.x
Stahmer A. C., 2005, FOCUS AUTISM OTHER D, V20, P66, DOI DOI 10.1177/1088357
Stahmer AC, 2009, PSYCHOL SERV, V6, P223, DOI 10.1037/a0010738
Tashakkoi A, 2003, HDB MIXED METHODS SO
Young Margaret B., 2012, Morbidity and Mortality Weekly Report, V61, P1
Volkmar F., 2005, HDB AUTISM PERVASIVE, P5
Wandersman A, 2008, AM J COMMUN PSYCHOL, V41, P171, DOI 10.1007/s10464-008-9174-z
WILLMS DG, 1990, MED ANTHROPOL Q, V4, P391, DOI 10.1525/maq.1990.4.4.02a00020
Wood JJ, 2009, J CHILD PSYCHOL PSYC, V50, P224, DOI 10.1111/j.1469-7610.2008.01948.x
Wood JJ, 2003, J CHILD PSYCHOL PSYC, V44, P134, DOI 10.1111/1469-7610.00106
Wood JJ, 2007, COGNITIVE BEHA UNPUB
NR 52
TC 3
Z9 3
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1748-5908
J9 IMPLEMENT SCI
JI Implement. Sci.
PD SEP 10
PY 2012
VL 7
AR 85
DI 10.1186/1748-5908-7-85
PG 10
WC Health Care Sciences & Services; Health Policy & Services
SC Health Care Sciences & Services
GA 039VD
UT WOS:000311274000001
PM 22963616
ER
PT J
AU Cossu, G
Boria, S
Copioli, C
Bracceschi, R
Giuberti, V
Santelli, E
Gallese, V
AF Cossu, Giuseppe
Boria, Sonia
Copioli, Cristiana
Bracceschi, Roberta
Giuberti, Virginia
Santelli, Erica
Gallese, Vittorio
TI Motor Representation of Actions in Children with Autism
SO PLOS ONE
LA English
DT Article
ID MIRROR-NEURON SYSTEM; EMOTIONAL FACIAL EXPRESSIONS; SPECTRUM-DISORDERS;
INTENTIONAL ATTUNEMENT; SOCIAL COGNITION; PREMOTOR CORTEX; IMITATION;
RECOGNITION; ORGANIZATION; PERFORMANCE
AB Background: Children with Autistic Spectrum Disorders (ASD) are frequently hampered by motor impairment, with difficulties ranging from imitation of actions to recognition of motor intentions. Such a widespread inefficiency of the motor system is likely to interfere on the ontogeny of both motor planning and understanding of the goals of actions, thus delivering its ultimate effects on the emergence of social cognition.
Methodology/Principal Findings: We investigate the organization of action representation in 15 high functioning ASD (mean age: 8.11) and in two control samples of typically developing (TD) children: the first one, from a primary school, was matched for chronological age (CA), the second one, from a kindergarten, comprised children of much younger age (CY). We used nine newly designed behavioural motor tasks, aiming at exploring three domains of motor cognition: 1) imitation of actions, 2) production of pantomimes, and 3) comprehension of pantomimes. The findings reveal that ASD children fare significantly worse than the two control samples in each of the inspected components of the motor representation of actions, be it the imitation of gestures, the self-planning of pantomimes, or the (verbal) comprehension of observed pantomimes. In the latter task, owing to its cognitive complexity, ASD children come close to the younger TD children's level of performance; yet they fare significantly worse with respect to their age-mate controls. Overall, ASD children reveal a profound damage to the mechanisms that control both production and pre-cognitive "comprehension" of the motor representation of actions.
Conclusions/Significance: Our findings suggest that many of the social cognitive impairments manifested by ASD individuals are likely rooted in their incapacity to assemble and directly grasp the intrinsic goal-related organization of motor behaviour. Such impairment of motor cognition might be partly due to an early damage of the Mirror Neuron Mechanism (MNM).
C1 [Cossu, Giuseppe; Boria, Sonia; Copioli, Cristiana; Bracceschi, Roberta; Gallese, Vittorio] Univ Parma, Dipartimento Neurosci, I-43100 Parma, Italy.
[Giuberti, Virginia; Santelli, Erica] AUSL Reggio Emilia, Unita Neuropsichiat Infantile, Reggio Emilia, Italy.
[Gallese, Vittorio] Italian Inst Technol, Brain Ctr Social & Motor Cognit, Parma, Italy.
RP Cossu, G (reprint author), Univ Parma, Dipartimento Neurosci, I-43100 Parma, Italy.
EM giuseppe.cossu@unipr.it
RI Macciardi, Fabio/N-3768-2014
FU Fondazione Monte Parma (FMP); Regione Emilia Romagna; MIUR (Ministero
Italiano dell'Universita e della Ricerca); EU grants
FX The study was supported by Fondazione Monte Parma (FMP), by Regione
Emilia Romagna, by MIUR (Ministero Italiano dell'Universita e della
Ricerca) and EU grants NESTCOM and DISCOS (to V.G.). The authors thank
A.M. Dalla Vecchia for her clinical contribution. The funders had no
role in study design, data collection and analysis, decision to publish,
or preparation of the manuscript.
CR American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th
Beall PM, 2008, J EXP CHILD PSYCHOL, V101, P206, DOI 10.1016/j.jecp.2008.04.004
Bernier R, 2007, BRAIN COGNITION, V64, P228, DOI 10.1016/j.bandc.2007.03.004
Bird G, 2007, P ROY SOC B-BIOL SCI, V274, P3027, DOI 10.1098/rspb.2007.1019
Boria S, 2009, PLOS ONE, V5, pe5596
Buccino G, 2004, J COGNITIVE NEUROSCI, V16, P114, DOI 10.1162/089892904322755601
Buccino G, 2004, NEURON, V42, P323, DOI 10.1016/S0896-6273(04)00181-3
RIZZOLATTI G, 1988, EXP BRAIN RES, V71, P491, DOI 10.1007/BF00248742
Cattaneo L, 2007, P NATL ACAD SCI USA, V104, P17825, DOI 10.1073/pnas.0706273104
Dapretto M, 2006, NAT NEUROSCI, V9, P28, DOI 10.1038/nn1611
DEMYER MK, 1972, J AUTISM CHILD SCHIZ, V2, P264, DOI 10.1007/BF01537618
Fogassi L, 2005, SCIENCE, V308, P662, DOI 10.1126/science.1106138
Gallese V, 2004, TRENDS COGN SCI, V8, P396, DOI 10.1016/j.tics.2004.07.002
Gallese V, 2003, PHILOS T ROY SOC B, V358, P1231, DOI 10.1098/rstb.2003.1315
Gallese V, 2007, J AM PSYCHOANAL ASS, V55, P131
Gallese V, 2009, DEV PSYCHOL, V45, P103, DOI 10.1037/a0014436
Gallese V., 2002, ATTENTION PERFORM, VXIX, P247
Gallese V, 1996, BRAIN, V119, P593, DOI 10.1093/brain/119.2.593
Gallese V, 2006, BRAIN RES, V1079, P15, DOI 10.1016/j.brainres.2006.01.054
Gallese V, 2012, DEV MED CHI IN PRESS
Grezes J, 2009, NEUROPSYCHOLOGIA, V47, P1816, DOI 10.1016/j.neuropsychologia.2009.02.021
Iacoboni M, 1999, SCIENCE, V286, P2526, DOI 10.1126/science.286.5449.2526
Iacoboni M, 2005, PLOS BIOL, V3, P529, DOI 10.1371/journal.pbio.0030079
Ingersoll B, 2003, J AUTISM DEV DISORD, V33, P673, DOI 10.1023/B:JADD.0000006003.26667.f8
Kanner L, 1943, NERV CHILD, V2, P217
Kilner JM, 2009, J NEUROSCI, V29, P10153, DOI 10.1523/JNEUROSCI.2668-09.2009
Leighton J, 2008, NEUROPSYCHOLOGIA, V46, P1041, DOI 10.1016/j.neuropsychologia.2007.11.013
LORD C, 1989, J AUTISM DEV DISORD, V19, P185, DOI 10.1007/BF02211841
MacNeil LK, 2012, NEUROPSYCHOLOGY, V26, P165, DOI 10.1037/a0026955
Martineau J, 2008, INT J PSYCHOPHYSIOL, V68, P35, DOI 10.1016/j.ijpsycho.2008.01.002
McIntosh DN, 2006, DEVELOPMENTAL SCI, V9, P295, DOI 10.1111/j.1467-7687.2006.00492.x
Moll J, 2000, NEUROLOGY, V54, P1331
Mukamel R., 2010, CURR BIOL, V20, P1
Nielsen M, 2008, J EXP CHILD PSYCHOL, V101, P165, DOI 10.1016/j.jecp.2008.06.004
Oberman LM, 2008, NEUROPSYCHOLOGIA, V46, P1558, DOI 10.1016/j.neuropsychologia.2008.01.010
Oberman LM, 2007, PSYCHOL BULL, V133, P310, DOI 10.1037/0033-2909.133.2.310
Oberman LM, 2005, COGNITIVE BRAIN RES, V24, P190, DOI 10.1016/j.cogbrainres.2005.01.014
Press C, 2010, NEUROPSYCHOLOGIA, V48, P3291, DOI 10.1016/j.neuropsychologia.2010.07.012
Raven J. C., 1984, COLOURED PROGR MATRI
Rizzolatti G, 1996, COGNITIVE BRAIN RES, V3, P131, DOI 10.1016/0926-6410(95)00038-0
Rizzolatti G, 2004, ANNU REV NEUROSCI, V27, P169, DOI 10.1146/annurev.neuro.27.070203.144230
Rizzolatti G., 2000, COGNITIVE NEUROSCIEN, P539
Rogers S. J., 1991, DEV PSYCHOPATHOL, V3, P137, DOI DOI 10.1017/S0954579400000043
Rogers S. J., 2006, IMITATION SOCIAL MIN, P277
Rogers SJ, 2010, DEV PSYCHOPATHOL, V22, P71, DOI 10.1017/S0954579409990277
Rubini V, 1986, WECHSLER INTELLIGENC
Sevlever M, 2010, RES DEV DISABIL, V31, P976, DOI 10.1016/j.ridd.2010.04.014
Theoret H., 2005, CURR BIOL, V15, P84
Watkins KE, 2002, BRAIN, V125, P452, DOI 10.1093/brain/awf058
Whiten A, 1999, INTERSUBJECTIVE COMM, P260
Williams JHG, 2004, J AUTISM DEV DISORD, V34, P285, DOI 10.1023/B:JADD.0000029551.56735.3a
NR 51
TC 5
Z9 5
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD SEP 10
PY 2012
VL 7
IS 9
AR e44779
DI 10.1371/journal.pone.0044779
PG 8
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 005KD
UT WOS:000308748400029
PM 22970304
ER
PT J
AU Moriguchi, Y
Shinohara, I
AF Moriguchi, Yusuke
Shinohara, Ikuko
TI My Neighbor: Children's Perception of Agency in Interaction with an
Imaginary Agent
SO PLOS ONE
LA English
DT Article
ID BIOLOGICAL MOTION; COMPANIONS; FANTASY; DISTINCTION; MONSTERS; REALITY;
AUTISM; KINDS; MIND
AB Children may treat an invisible entity as a live and thinking entity, known as an imaginary companion (IC). Some researchers suggest that this is simply pretend play, but it is possible that children experience agency in their interactions with ICs. Given the literature on cognitive science and social brain research, we hypothesize that young children may have an agent-perception system that responds to an invisible agent by which they may experience realistic agency in their interactions with ICs. In this study, children were introduced to an invisible agent and an invisible stone. However, they assigned biological and psychological properties to the agent but not the stone. The tendency of assigning such properties was stronger in children with ICs than in those without ICs. These results contribute to our understanding of cognitive and neural development in typical and atypical children.
C1 [Moriguchi, Yusuke] Joetsu Univ Educ, Dept Sch Educ, Joetsu, Japan.
[Moriguchi, Yusuke] Japan Sci & Technol Agcy, Precursory Res Embryon Sci & Technol, Tokyo, Japan.
[Shinohara, Ikuko] Aichi Shukutoku Univ, Dept Psychol, Nagakute, Aichi, Japan.
RP Moriguchi, Y (reprint author), Joetsu Univ Educ, Dept Sch Educ, Joetsu, Japan.
EM moriguchi@juen.ac.jp
FU Japan Science and Technology Agency
FX This research was supported by grants from the Japan Science and
Technology Agency, recursory Research for Embryonic Science and
Technology program to the first author
(http://www.jst.go.jp/kisoken/presto/index_e.html). The funders had no
role in study design, data collection and analysis, decision to publish,
or preparation of the manuscript.
CR Baltaxe CA, 1977, J PEDIATR PSYCHOL, V2, P176, DOI DOI 10.1093/JPEPSY/2.4.176
Barrett JL, 2001, CHILD DEV, V72, P50, DOI 10.1111/1467-8624.00265
Bouldin P, 2001, BRIT J DEV PSYCHOL, V19, P99, DOI 10.1348/026151001165985
Boyer P., 2002, RELIG EXPLAINED EVOL
Brothers L., 1990, CONCEPTS NEUROSCIENC, V1, P27
Carlson SM, 2005, MERRILL PALMER QUART, V51, P93, DOI 10.1353/mpq.2005.0003
Carter EJ, 2006, SOC NEUROSCI, V1, P396, DOI 10.1080/17470910601041382
DeLoache JS, 2004, SCIENCE, V304, P1027, DOI 10.1126/science.1093567
Frith CD, 1999, SCIENCE, V286, P1692, DOI 10.1126/science.286.5445.1692
Gelman R, 1983, DEV SYMBOLIC THOUGHT, P297
Gleason TR, 2000, DEV PSYCHOL, V36, P419, DOI 10.1037//0012-1649.36.4.419
Grossman ED, 2001, VISION RES, V41, P1475, DOI 10.1016/S0042-6989(00)00317-5
Guthrie Stewart, 1995, FACES CLOUDS NEW THE
Harris PL, 2000, WORK IMAGINATION
HARRIS PL, 1991, BRIT J DEV PSYCHOL, V9, P105
Jipson JL, 2007, CHILD DEV, V78, P1675, DOI 10.1111/j.1467-8624.2007.01095.x
McGuire D, 2006, MENTAL WELLNESS ADUL
Piaget J., 1929, CHILDS CONCEPTION WO
Roby AC, 2008, DEVELOPMENTAL SCI, V11, P531, DOI 10.1111/j.1467-7687.2008.00699.x
Saxe R, 2006, SOC COGN AFFECT NEUR, V1, P229, DOI 10.1093/scan/nsl034
Sharon T, 2004, BRIT J DEV PSYCHOL, V22, P293, DOI 10.1348/026151004323044627
Sigman M, 1999, MONOGR SOC RES CHILD, V64, P1, DOI 10.1111/1540-5834.00002
SPRINGER K, 1991, CHILD DEV, V62, P767, DOI 10.2307/1131176
Svendsen M, 1934, ARCH NEURO PSYCHIATR, V32, P985
Taylor M., 1999, IMAGINARY COMPANIONS
TAYLOR M, 1993, DEV PSYCHOL, V29, P276, DOI 10.1037/0012-1649.29.2.276
Taylor M, 1997, CHILD DEV, V68, P436, DOI 10.1111/j.1467-8624.1997.tb01950.x
Tshuji H, 1992, PIANISSIMO
Ueno K., 2008, PICTURE VOCABULARY T
Wheatley T, 2007, PSYCHOL SCI, V18, P469, DOI 10.1111/j.1467-9280.2007.01923.x
WOOLLEY JD, 1993, CHILD DEV, V64, P1
Zilbovicius M, 2006, TRENDS NEUROSCI, V29, P359, DOI 10.1016/j.tins.2006.06.004
NR 32
TC 1
Z9 1
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD SEP 7
PY 2012
VL 7
IS 9
AR e44463
DI 10.1371/journal.pone.0044463
PG 6
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 001LK
UT WOS:000308462000022
PM 22970225
ER
PT J
AU Rudie, JD
Hernandez, LM
Brown, JA
Beck-Pancer, D
Colich, NL
Gorrindo, P
Thompson, PM
Geschwind, DH
Bookheimer, SY
Levitt, P
Dapretto, M
AF Rudie, Jeffrey D.
Hernandez, Leanna M.
Brown, Jesse A.
Beck-Pancer, Devora
Colich, Natalie L.
Gorrindo, Philip
Thompson, Paul M.
Geschwind, Daniel H.
Bookheimer, Susan Y.
Levitt, Pat
Dapretto, Mirella
TI Autism-Associated Promoter Variant in MET Impacts Functional and
Structural Brain Networks
SO NEURON
LA English
DT Article
ID RECEPTOR TYROSINE KINASE; DE-NOVO MUTATIONS; SPECTRUM DISORDERS;
WHITE-MATTER; SPATIAL-STATISTICS; ASPERGER-SYNDROME; NEURAL CIRCUITRY;
GENETIC VARIANT; MOUSE FOREBRAIN; FRONTAL-CORTEX
AB As genes that confer increased risk for autism spectrum disorder (ASD) are identified, a crucial next step is to determine how these risk factors impact brain structure and function and contribute to disorder heterogeneity. With three converging lines of evidence, we show that a common, functional ASD risk variant in the Met Receptor Tyrosine Kinase (MET) gene is a potent modulator of key social brain circuitry in children and adolescents with and without ASD. MET risk genotype predicted atypical fMRI activation and deactivation patterns to social stimuli (i.e., emotional faces), as well as reduced functional and structural connectivity in temporo-parietal regions known to have high MET expression, particularly within the default mode network. Notably, these effects were more pronounced in individuals with ASD. These findings highlight how genetic stratification may reduce heterogeneity and help elucidate the biological basis of complex neuropsychiatric disorders such as ASD.
C1 [Rudie, Jeffrey D.; Hernandez, Leanna M.; Beck-Pancer, Devora; Colich, Natalie L.; Dapretto, Mirella] Univ Calif Los Angeles, Ahmanson Lovelace Brain Mapping Ctr, Los Angeles, CA 90095 USA.
[Rudie, Jeffrey D.; Brown, Jesse A.] Univ Calif Los Angeles, Interdept Neurosci Program, Los Angeles, CA 90095 USA.
[Hernandez, Leanna M.; Beck-Pancer, Devora; Thompson, Paul M.; Geschwind, Daniel H.; Bookheimer, Susan Y.; Dapretto, Mirella] Univ Calif Los Angeles, Dept Psychiat & Biobehav Sci, Los Angeles, CA 90095 USA.
[Levitt, Pat] Univ So Calif, Keck Sch Med, Dept Cell & Neurobiol, Zilkha Neurogenet Inst, Los Angeles, CA 90089 USA.
[Thompson, Paul M.; Geschwind, Daniel H.] Univ Calif Los Angeles, Dept Neurol, Los Angeles, CA 90095 USA.
[Geschwind, Daniel H.] Univ Calif Los Angeles, Dept Human Genet, Los Angeles, CA 90095 USA.
RP Dapretto, M (reprint author), Univ Calif Los Angeles, Ahmanson Lovelace Brain Mapping Ctr, Los Angeles, CA 90095 USA.
EM mirella@loni.ucla.edu
FU NICHD [P50 HD055784]; NIMH [R01 HD06528001, NIMH 1R01 MH080759, T32
GM008044, T32 MH073526-05]; NIH [RR12169, RR13642, RR00865]; Autism
Speaks
FX This work was supported by NICHD Grant P50 HD055784 (to S.Y.B.), NIMH
Grants R01 HD06528001 (to S.Y.B.), NIMH 1R01 MH080759 (to P.L.), T32
GM008044 (to J.D.R.), T32 MH073526-05 (to J.D.R.), NIH Grants (RR12169,
RR13642, and RR00865), and Autism Speaks. We thank Z. Shehzad, B.
Abrahams, and K. Eagleson for commenting on the manuscript as well as J.
Pfiefer, K. McNeally, L. Borofsky, A. Martin, and B. Way for help with
data collection.
CR Alexander AL, 2007, NEUROIMAGE, V34, P61, DOI 10.1016/j.neuroimage.2006.08.032
Anderson JS, 2011, CEREB CORTEX, V21, P1134, DOI 10.1093/cercor/bhq190
Anney R, 2010, HUM MOL GENET, V19, P4072, DOI 10.1093/hmg/ddq307
Ashwin E, 2009, BIOL PSYCHIAT, V65, P17, DOI 10.1016/j.biopsych.2008.06.012
Assaf M, 2010, NEUROIMAGE, V53, P247, DOI 10.1016/j.neuroimage.2010.05.067
BAILEY A, 1995, PSYCHOL MED, V25, P63
Baranek GT, 2006, J CHILD PSYCHOL PSYC, V47, P591, DOI 10.1111/j.1469-7610.2005.01546.x
Barnea-Goraly N, 2010, ARCH GEN PSYCHIAT, V67, P1052, DOI 10.1001/archgenpsychiatry.2010.123
Barnea-Goraly N, 2004, BIOL PSYCHIAT, V55, P323, DOI 10.1016/j.biopsych.2003.10.022
Baron-Cohen S, 2009, PHILOS T R SOC B, V364, P1377, DOI 10.1098/rstb.2008.0337
Baron-Cohen S, 2000, NEUROSCI BIOBEHAV R, V24, P355, DOI 10.1016/S0149-7634(00)00011-7
Belmonte MK, 2004, J NEUROSCI, V24, P9228, DOI 10.1523/JNEUROSCI.3340-04.2004
Ben-Sasson A, 2007, AM J OCCUP THER, V61, P584
Biswal BB, 2010, P NATL ACAD SCI USA, V107, P4734, DOI 10.1073/pnas.0911855107
Bode MK, 2011, ACTA RADIOL, V52, P1169, DOI 10.1258/ar.2011.110197
Buxbaum JD, 2012, MOL AUTISM, V3, DOI 10.1186/2040-2392-3-1
Campbell DB, 2006, P NATL ACAD SCI USA, V103, P16834, DOI 10.1073/pnas.0605296103
Campbell DB, 2010, AM J MED GENET B, V153B, P438, DOI 10.1002/ajmg.b.30998
Campbell DB, 2007, ANN NEUROL, V62, P243, DOI 10.1002/ana.21180
Campbell DB, 2008, AUTISM RES, V1, P159, DOI 10.1002/aur.27
Castelli F, 2002, BRAIN, V125, P1839, DOI 10.1093/brain/awf189
Cheng YW, 2010, NEUROIMAGE, V50, P873, DOI 10.1016/j.neuroimage.2010.01.011
Cherkassky VL, 2006, NEUROREPORT, V17, P1687, DOI 10.1097/01.wnr.0000239956.45448.4c
Cheung C, 2009, J CHILD PSYCHOL PSYC, V50, P1102, DOI 10.1111/j.1469-7610.2009.02086.x
Chiang MC, 2011, NEUROIMAGE, V54, P2308, DOI 10.1016/j.neuroimage.2010.10.015
Courchesne E, 2005, CURR OPIN NEUROBIOL, V15, P225, DOI 10.1016/j.conb.2005.03.001
Critchley HD, 2000, BRAIN, V123, P2203, DOI 10.1093/brain/123.11.2203
Dalton KM, 2005, NAT NEUROSCI, V8, P519, DOI 10.1038/nn1421
Dapretto M, 2006, NAT NEUROSCI, V9, P28, DOI 10.1038/nn1611
Dennis Emily L, 2011, Brain Connect, V1, P447, DOI 10.1089/brain.2011.0064
Di Martino A, 2009, BIOL PSYCHIAT, V65, P63, DOI 10.1016/j.biopsych.2008.09.022
Dinstein I, 2011, NEURON, V70, P1218, DOI 10.1016/j.neuron.2011.04.018
Dosenbach NUF, 2010, SCIENCE, V329, P1358, DOI 10.1126/science.1194144
Eagleson KL, 2011, AUTISM RES, V4, P68, DOI 10.1002/aur.172
Fornito A, 2011, J NEUROSCI, V31, P3261, DOI 10.1523/JNEUROSCI.4858-10.2011
Fox MD, 2005, P NATL ACAD SCI USA, V102, P9673, DOI 10.1073/pnas.0504136102
Fox Michael D, 2010, Front Syst Neurosci, V4, P19, DOI 10.3389/fnsys.2010.00019
Geschwind DH, 2007, CURR OPIN NEUROBIOL, V17, P103, DOI 10.1016/j.conb.2007.01.009
Geschwind DH, 2011, TRENDS COGN SCI, V15, P409, DOI 10.1016/j.tics.2011.07.003
Glahn DC, 2010, P NATL ACAD SCI USA, V107, P1223, DOI 10.1073/pnas.0909969107
Gottesman II, 2003, AM J PSYCHIAT, V160, P636, DOI 10.1176/appi.ajp.160.4.636
Hadjikhani N, 2004, NEUROIMAGE, V22, P1141, DOI 10.1016/j.neuroimage.2004.03.025
Hagmann P, 2008, PLOS BIOL, V6, P1479, DOI 10.1371/journal.pbio.0060159
Hallmayer J, 2011, ARCH GEN PSYCHIAT, V68, P1095, DOI 10.1001/archgenpsychiatry.2011.76
Heuer L, 2011, TRANSL PSYCHIAT, V1, DOI 10.1038/tp.2011.48
Jackson PB, 2009, AUTISM RES, V2, P232, DOI 10.1002/aur.87
Jones CRG, 2009, NEUROPSYCHOLOGIA, V47, P2850, DOI 10.1016/j.neuropsychologia.2009.06.015
Judson MC, 2011, CEREB CORTEX, V21, P1613, DOI 10.1093/cercor/bhq223
Judson MC, 2011, J NEURODEV DISORD, V3, P282, DOI 10.1007/s11689-011-9081-8
Judson MC, 2009, J COMP NEUROL, V513, P511, DOI 10.1002/cne.21969
Judson MC, 2010, J COMP NEUROL, V518, P4463, DOI 10.1002/cne.22467
Just MA, 2004, BRAIN, V127, P1811, DOI 10.1093/brain/awh199
Kaiser MD, 2010, P NATL ACAD SCI USA, V107, P21223, DOI 10.1073/pnas.1010412107
Kennedy DP, 2006, P NATL ACAD SCI USA, V103, P8275, DOI 10.1073/pnas.0600674103
Kennedy DP, 2008, NEUROIMAGE, V39, P1877, DOI 10.1016/j.neuroimage.2007.10.052
Kleinhans NM, 2008, BRAIN, V131, P1000, DOI 10.1093/brain/awm334
Kochunov P, 2010, NEUROIMAGE, V53, P1109, DOI 10.1016/j.neuroimage.2010.01.078
Konopka G, 2009, NATURE, V462, P213, DOI 10.1038/nature08549
Koten JW, 2009, SCIENCE, V323, P1737, DOI 10.1126/science.1167371
Laurienti PJ, 2002, J COGNITIVE NEUROSCI, V14, P420, DOI 10.1162/089892902317361930
Levitt P, 2009, J CLIN INVEST, V119, P747, DOI 10.1172/JCI37934
Lin P, 2011, CEREB CORTEX, V21, P821, DOI 10.1093/cercor/bhq151
Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
lossifov I., 2012, NEURON, V74, P285
Marshall CR, 2008, AM J HUM GENET, V82, P477, DOI 10.1016/j.ajhg.2007.12.009
Monk CS, 2010, J PSYCHIATR NEUROSCI, V35, P105, DOI 10.1503/jpn.090085
Monk CS, 2009, NEUROIMAGE, V47, P764, DOI 10.1016/j.neuroimage.2009.04.069
Mukamel Z, 2011, J NEUROSCI, V31, P11437, DOI 10.1523/JNEUROSCI.0181-11.2011
Neale BM, 2012, NATURE, V485, P242, DOI 10.1038/nature11011
O'Roak BJ, 2012, NATURE, V485, P246, DOI 10.1038/nature10989
Pfeifer JH, 2008, NEUROIMAGE, V39, P2076, DOI 10.1016/j.neuroimage.2007.10.032
Pfeifer JH, 2011, NEURON, V69, P1029, DOI 10.1016/j.neuron.2011.02.019
Pierce K, 2004, BRAIN, V127, P2703, DOI 10.1093/brain/awh289
Pinto D, 2010, NATURE, V466, P368, DOI 10.1038/nature09146
Qiu SF, 2011, J NEUROSCI, V31, P5855, DOI 10.1523/JNEUROSCI.6569-10.2011
Raichle ME, 2001, P NATL ACAD SCI USA, V98, P676, DOI 10.1073/pnas.98.2.676
Rasetti R, 2011, CURR OPIN GENET DEV, V21, P340, DOI 10.1016/j.gde.2011.02.003
Rosenberg RE, 2009, ARCH PEDIAT ADOL MED, V163, P907, DOI 10.1001/archpediatrics.2009.98
Sanders SJ, 2012, NATURE, V485, P237, DOI 10.1038/nature10945
Schultz RT, 2000, ARCH GEN PSYCHIAT, V57, P331, DOI 10.1001/archpsyc.57.4.331
Scott-Van Zeeland AA, 2010, SCI TRANSL MED, V2, DOI 10.1126/scitranslmed.3001344
Shukla DK, 2011, NEUROPSYCHOLOGIA, V49, P1378, DOI 10.1016/j.neuropsychologia.2011.02.022
Smith SM, 2006, NEUROIMAGE, V31, P1487, DOI 10.1016/j.neuroimage.2006.02.024
Sousa I, 2009, EUR J HUM GENET, V17, P749, DOI 10.1038/ejhg.2008.215
Spencer MD, 2011, TRANSL PSYCHIAT, V1, DOI 10.1038/tp.2011.18
State MW, 2011, NAT NEUROSCI, V14, P1499, DOI 10.1038/nn.2924
Sundaram SK, 2008, CEREB CORTEX, V18, P2659, DOI 10.1093/cercor/bhn031
Thanseem I, 2010, NEUROSCI RES, V68, P137, DOI 10.1016/j.neures.2010.06.014
Vernes SC, 2008, NEW ENGL J MED, V359, P2337, DOI 10.1056/NEJMoa0802828
Villalobos ME, 2005, NEUROIMAGE, V25, P916, DOI 10.1016/j.neuroimage.2004.12.022
Vissers ME, 2012, NEUROSCI BIOBEHAV R, V36, P604, DOI 10.1016/j.neubiorev.2011.09.003
Voineagu I, 2011, NATURE, V474, P380, DOI 10.1038/nature10110
Wang K, 2009, NATURE, V459, P528, DOI 10.1038/nature07999
Weiss LA, 2009, NATURE, V461, P802, DOI 10.1038/nature08490
Weng SJ, 2010, BRAIN RES, V1313, P202, DOI 10.1016/j.brainres.2009.11.057
Xu LM, 2012, NUCLEIC ACIDS RES, V40, pD1016, DOI 10.1093/nar/gkr1145
NR 96
TC 36
Z9 36
PU CELL PRESS
PI CAMBRIDGE
PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA
SN 0896-6273
J9 NEURON
JI Neuron
PD SEP 6
PY 2012
VL 75
IS 5
BP 904
EP 915
DI 10.1016/j.neuron.2012.07.010
PG 12
WC Neurosciences
SC Neurosciences & Neurology
GA 004LX
UT WOS:000308684300016
PM 22958829
ER
PT J
AU Nackaerts, E
Wagemans, J
Helsen, W
Swinnen, SP
Wenderoth, N
Alaerts, K
AF Nackaerts, Evelien
Wagemans, Johan
Helsen, Werner
Swinnen, Stephan P.
Wenderoth, Nicole
Alaerts, Kaat
TI Recognizing Biological Motion and Emotions from Point-Light Displays in
Autism Spectrum Disorders
SO PLOS ONE
LA English
DT Article
ID HIGH-FUNCTIONING AUTISM; EYE-MOVEMENTS; VISUAL-PERCEPTION; MIRROR
NEURONS; SHORT FORMS; CHILDREN; RECOGNITION; PATTERNS; SCALE;
INDIVIDUALS
AB One of the main characteristics of Autism Spectrum Disorder (ASD) are problems with social interaction and communication. Here, we explored ASD-related alterations in 'reading' body language of other humans. Accuracy and reaction times were assessed from two observational tasks involving the recognition of 'biological motion' and 'emotions' from point-light displays (PLDs). Eye movements were recorded during the completion of the tests. Results indicated that typically developed-participants were more accurate than ASD-subjects in recognizing biological motion or emotions from PLDs. No accuracy differences were revealed on two control-tasks (involving the indication of color-changes in the moving point-lights). Group differences in reaction times existed on all tasks, but effect sizes were higher for the biological and emotion recognition tasks. Biological motion recognition abilities were related to a person's ability to recognize emotions from PLDs. However, ASD-related atypicalities in emotion recognition could not entirely be attributed to more basic deficits in biological motion recognition, suggesting an additional ASD-specific deficit in recognizing the emotional dimension of the point light displays. Eye movements were assessed during the completion of tasks and results indicated that ASD-participants generally produced more saccades and shorter fixation-durations compared to the control-group. However, especially for emotion recognition, these altered eye movements were associated with reductions in task-performance.
C1 [Nackaerts, Evelien; Helsen, Werner; Swinnen, Stephan P.; Wenderoth, Nicole; Alaerts, Kaat] Katholieke Univ Leuven, Res Ctr Movement Control & Neuroplast, Grp Biomed Sci, Dept Biomed Kinesiol, Heverlee, Belgium.
[Wagemans, Johan] Katholieke Univ Leuven, Expt Psychol Lab, Louvain, Belgium.
[Wenderoth, Nicole] ETH, Dept Hlth Sci & Technol, Neural Control Movement Lab, Zurich, Switzerland.
RP Nackaerts, E (reprint author), Katholieke Univ Leuven, Res Ctr Movement Control & Neuroplast, Grp Biomed Sci, Dept Biomed Kinesiol, Heverlee, Belgium.
EM Kaat.Alaerts@faber.kuleuven.be
RI Wenderoth, Nicole/D-7262-2015
OI Wenderoth, Nicole/0000-0002-3246-9386
FU Flanders Fund for Scientific Research (FWO) [G.0758.10]; FWO;
Interuniversity Attraction Poles program of the Belgian federal
government [P6/29]; Research Council of the University of Leuven
[IDO/08/013]; Flemish government [METH/08/02]
FX Support for this study was provided through grants from the Flanders
Fund for Scientific Research (FWO projectsG.0758.10). KA is supported by
a FWO postdoctoral Research fellowship grant. This work was also
supported by Grant P6/29 from the Interuniversity Attraction Poles
program of the Belgian federal government. This study has been conducted
in collaboration with the Leuven Autism Research Consortium (LAuRes),
funded by the Research Council of the University of Leuven (IDO/08/013).
JW is supported by the Methusalem program of the Flemish government
(METH/08/02). The funders had no role in study design, data collection
and analysis, decision to publish, or preparation of the manuscript.
CR Alaerts K, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0020989
American Psychiatric Association (APA), 1994, DIAGN STAT MAN MENT, V4th
Annaz D, 2010, DEVELOPMENTAL SCI, V13, P826, DOI 10.1111/j.1467-7687.2009.00939.x
Atkinson AP, 2009, NEUROPSYCHOLOGIA, V47, P3023, DOI 10.1016/j.neuropsychologia.2009.05.019
Blake R, 2003, PSYCHOL SCI, V14, P151, DOI 10.1111/1467-9280.01434
Boraston Z, 2007, J PHYSIOL-LONDON, V581, P893, DOI 10.1113/jphysiol.2007.133587
Brenner LA, 2007, J AUTISM DEV DISORD, V37, P1289, DOI 10.1007/s10803-006-0277-9
Brownlow S, 1997, PSYCHOL REC, V47, P411
Catteeuw P, 2009, J SPORT EXERCISE PSY, V31, P786
Chouchourelou A, 2006, SOC NEUROSCI, V1, P63, DOI 10.1080/17470910600630599
Constantino JN, 2004, J CHILD PSYCHOL PSYC, V45, P719, DOI 10.1111/j.1469-7610.2004.00266.x
Constantino JN, 2003, J AUTISM DEV DISORD, V33, P427, DOI 10.1023/A:1025014929212
Corden B, 2008, NEUROPSYCHOLOGIA, V46, P137, DOI 10.1016/j.neuropsychologia.2007.08.005
CUTTING JE, 1977, B PSYCHONOMIC SOC, V9, P353
Dittrich WH, 1996, PERCEPTION, V25, P727, DOI 10.1068/p250727
Evers K, 2011, RES AUTISM SPECT DIS, V5, P1327, DOI 10.1016/j.rasd.2011.01.004
Fan YT, 2010, J CHILD PSYCHOL PSYC, V51, P981, DOI 10.1111/j.1469-7610.2010.02269.x
Freitag CM, 2008, NEUROPSYCHOLOGIA, V46, P1480, DOI 10.1016/j.neuropsychologia.2007.12.025
FRITH U, 1994, COGNITION, V50, P115, DOI 10.1016/0010-0277(94)90024-8
Girard TA, 2010, ASSESSMENT, V17, P400, DOI 10.1177/1073191110369763
Goldberg MC, 2002, NEUROPSYCHOLOGIA, V40, P2039, DOI 10.1016/S0028-3932(02)00059-3
Happe F, 2006, J AUTISM DEV DISORD, V36, P5, DOI 10.1007/s10803-005-0039-0
Harms MB, 2010, NEUROPSYCHOL REV, V20, P290, DOI 10.1007/s11065-010-9138-6
Hubert B, 2007, J AUTISM DEV DISORD, V37, P1386, DOI 10.1007/s10803-006-0275-y
Ikeda H, 2009, PERCEPTION, V38, P1002, DOI 10.1068/p6250
Jastorff J, 2009, J NEUROSCI, V29, P7315, DOI 10.1523/JNEUROSCI.4870-08.2009
JOHANSSO.G, 1973, PERCEPT PSYCHOPHYS, V14, P201, DOI 10.3758/BF03212378
Joseph RM, 2009, DEVELOPMENTAL SCI, V12, P1083, DOI 10.1111/j.1467-7687.2009.00855.x
Kaiser MD, 2009, PSYCHON B REV, V16, P761, DOI 10.3758/PBR.16.5.761
Keehn B, 2009, J AUTISM DEV DISORD, V39, P383, DOI 10.1007/s10803-008-0608-0
Kemner C, 1998, J AUTISM DEV DISORD, V28, P61, DOI 10.1023/A:1026015120128
Klin A, 2009, NATURE, V459, P257, DOI 10.1038/nature07868
Klin A, 2002, ARCH GEN PSYCHIAT, V59, P809, DOI 10.1001/archpsyc.59.9.809
Koldewyn K, 2010, BRAIN, V133, P599, DOI 10.1093/brain/awp272
Moore DG, 1997, BRIT J DEV PSYCHOL, V15, P401
Murphy P, 2009, NEUROPSYCHOLOGIA, V47, P3225, DOI 10.1016/j.neuropsychologia.2009.07.026
Neri P, 2006, NAT NEUROSCI, V9, P1186, DOI 10.1038/nn1759
Parron C, 2008, AUTISM, V12, P261, DOI 10.1177/1362361307089520
Pelphrey KA, 2002, J AUTISM DEV DISORD, V32, P249, DOI 10.1023/A:1016374617369
Pelphrey KA, 2011, J CHILD PSYCHOL PSYC, V52, P631, DOI 10.1111/j.1469-7610.2010.02349.x
Perry A, 2010, SOC NEUROSCI-UK, V5, P272, DOI 10.1080/17470910903395767
Rommelse NN, 2007, BRAIN COGNITION, V68, P391
Ryan JJ, 1999, PSYCHOL ASSESSMENT, V11, P207, DOI 10.1037/1040-3590.11.2.207
Saygin AP, 2007, BRAIN, V130, P2452, DOI 10.1093/brain/awm162
Saygin AP, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0013491
Saygin AP, 2004, J NEUROSCI, V24, P6181, DOI 10.1523/JNEUROSCI.0504-04.2004
Snow J, 2011, J INT NEUROPSYCH SOC, V17, P1021, DOI 10.1017/S1355617711000981
Ulloa ER, 2007, BEHAV BRAIN RES, V183, P188, DOI 10.1016/j.bbr.2007.06.007
van der Geest JN, 2001, BIOL PSYCHIAT, V50, P614, DOI 10.1016/S0006-3223(01)01070-8
Wechsler D., 1997, WAIS 3 WECHSLER ADUL
Williams JHG, 2001, NEUROSCI BIOBEHAV R, V25, P287, DOI 10.1016/S0149-7634(01)00014-8
NR 51
TC 22
Z9 23
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD SEP 6
PY 2012
VL 7
IS 9
AR e44473
DI 10.1371/journal.pone.0044473
PG 12
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 001KC
UT WOS:000308458400075
PM 22970227
ER
PT J
AU Latapy, C
Rioux, V
Guitton, MJ
Beaulieu, JM
AF Latapy, Camille
Rioux, Veronique
Guitton, Matthieu J.
Beaulieu, Jean-Martin
TI Selective deletion of forebrain glycogen synthase kinase 3 beta reveals
a central role in serotonin-sensitive anxiety and social behaviour
SO PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
LA English
DT Article
DE serotonin; mood disorders; glycogen synthase kinase 3 beta; cortex;
anxiety; sociability
ID SIGNALING CASCADE; DOPAMINE TRANSPORTER; MOOD DISORDERS; MICE LACKING;
MOUSE MODEL; EUROPE 2010; IN-VIVO; LITHIUM; BRAIN; SCHIZOPHRENIA
AB Serotonin (5-HT) neurotransmission is thought to underlie mental illnesses, such as bipolar disorder, depression, autism and schizophrenia. Independent studies have indicated that 5-HT or drugs acting on 5-HT neurotransmission regulate the serine/threonine kinase glycogen synthase kinase 3 beta (GSK3 beta). Furthermore, GSK3 beta inhibition rescues behavioural abnormalities in 5-HT-deficient mice with a loss-of-function mutation equivalent to the human variant (R441H) of tryptophan hydroxylase 2. In an effort to define neuroanatomical correlates of GSK3 beta activity in the regulation of behaviour, we generated CamKIIcre-floxGSK3 beta mice in which the gsk3b gene is postnatally inactivated in forebrain pyramidal neurons. Behavioural characterization showed that suppression of GSK3 beta in these brain areas has anxiolytic and pro-social effects. However, while a global reduction of GSK2 beta expression reduced responsiveness to amphetamine and increased resilience to social defeat, these behavioural effects were not found in CamKIIcre-floxGSK3 beta mice. These findings demonstrate a dissociation of behavioural effects related to GSK3 inhibition, with forebrain GSK3 beta being involved in the regulation of anxiety and sociability while social preference, resilience and responsiveness to psychostimulants would involve a function of this kinase in subcortical areas such as the hippocampus and striatum.
C1 [Latapy, Camille; Rioux, Veronique; Beaulieu, Jean-Martin] Univ Laval, Dept Psychiat & Neurosci, Quebec City, PQ, Canada.
[Guitton, Matthieu J.] Univ Laval, Fac Med, Dept Otorhinolaryngol & Ophthalmol, Quebec City, PQ G1K 7P4, Canada.
[Guitton, Matthieu J.; Beaulieu, Jean-Martin] Mental Hlth Univ Inst Quebec, Behav Phenotyping Core Facil, Quebec City, PQ G1R 2G3, Canada.
RP Beaulieu, JM (reprint author), Univ Laval, Dept Psychiat & Neurosci, Quebec City, PQ, Canada.
EM martin.beaulieu@crulrg.ulaval.ca
RI Beaulieu, Jean-Martin/A-7598-2008
OI Beaulieu, Jean-Martin/0000-0002-0446-7447
FU Canadian Institutes of Health Research (CIHR) [NSA 93798]; 'Fond de la
Recherche en Sante du Quebec' (FRSQ); Centre de recherche sur le
cerveau, le comportement et la neuropsychiatrie (CRCN)
FX We acknowledge the dedication of Nathalie Bouchard and Kathye Aube in
maintaining our mouse colonies. GSK3 beta flox and GSK3 beta HET mice
were kind gifts from Dr James Woodgett, Samuel Lunenfeld Research
Institute, Toronto, Canada. This work was supported by the Canadian
Institutes of Health Research (CIHR; grant NSA 93798), and a strategic
innovation development project grant from the 'Fond de la Recherche en
Sante du Quebec' (FRSQ). J.-M.B. holds a Canada Research Chair in
Molecular Psychiatry and is a National Alliance for Research on
Schizophrenia and Depression (NARSAD) Vital Projects Fund, Inc.
Investigator. M.J.G. holds a Career Grant from the FRSQ. V.R. is
supported by a Banting fellowship from the CIHR and C.L. holds a
research fellowship from Centre de recherche sur le cerveau, le
comportement et la neuropsychiatrie (CRCN).
CR Bateup HS, 2010, P NATL ACAD SCI USA, V107, P14845, DOI 10.1073/pnas.1009874107
Beaulieu J. M., 2011, J PSYCHIATR NEUROSCI, V36, DOI DOI 10.1503/JPN.110011
Beaulieu JM, 2007, INT J NEUROPSYCHOPH, V10, P3, DOI 10.1017/S1461145706006857
Beaulieu JM, 2008, P NATL ACAD SCI USA, V105, P1333, DOI 10.1073/pnas.0711496105
Beaulieu JM, 2011, PHARMACOL REV, V63, P182, DOI 10.1124/pr.110.002642
Beaulieu JM, 2008, MOL INTERV, V8, P230, DOI 10.1124/mi.8.5.8
Beaulieu JM, 2009, ANNU REV PHARMACOL, V49, P327, DOI 10.1146/annurev.pharmtox.011008.145634
Beaulieu JM, 2008, P NATL ACAD SCI USA, V105, pE24, DOI DOI 10.1073/PNAS.0803026105
Beaulieu JM, 2006, J BIOL CHEM, V281, P32072, DOI 10.1074/jbc.M606062200
Beaulieu JM, 2007, TRENDS PHARMACOL SCI, V28, P166, DOI 10.1016/j.tips.2007.02.006
Beaulieu JM, 2003, J NEUROCHEM, V85, P248, DOI 10.1046/j.1471-4159.2003.01653.x
Beaulieu JM, 2008, CELL, V132, P125, DOI 10.1016/j.cell.2007.11.041
Beaulieu JM, 2011, FRONT MOL NEUROSCI, V4, DOI 10.3389/fnmol.2011.00038
Beaulieu JM, 2005, CELL, V122, P261, DOI 10.1016/j.cell.2005.05.012
Beaulieu JM, 2004, P NATL ACAD SCI USA, V101, P5099, DOI 10.1073/pnas.0307921101
Beaulieu JM, 2007, J NEUROSCI, V27, P881, DOI 10.1523/JNEUROSCI.5074-06.2007
Berton O, 2006, SCIENCE, V311, P864, DOI 10.1126/science.1120972
Beurel E, 2009, J NEUROINFLAMM, V6, DOI 10.1186/1742-2094-6-9
Beurel E, 2011, MOL PSYCHIATR, V16, P1068, DOI 10.1038/mp.2011.47
Blakely RD, 2005, NEURON, V48, P701, DOI 10.1016/j.neuron.2005.11.029
BLIER P, 1980, N-S ARCH PHARMACOL, V314, P123, DOI 10.1007/BF00504527
CARLSSON A, 1987, ANNU REV NEUROSCI, V10, P19
Carlsson A, 1968, J Pharm Pharmacol, V20, P150
Carlsson A, 2001, ANNU REV PHARMACOL, V41, P237, DOI 10.1146/annurev.pharmtox.41.1.237
Chalecka-Franaszek E, 1999, P NATL ACAD SCI USA, V96, P8745, DOI 10.1073/pnas.96.15.8745
Crowley JJ, 2004, PHARMACOL BIOCHEM BE, V78, P269, DOI 10.1016/j.pbb.2004.03.014
Kalinichev M, 2011, INT J NEUROPSYCHOPH, V14, P1051, DOI 10.1017/S1461145710001495
Deltheil T, 2008, NEUROPHARMACOLOGY, V55, P1006, DOI 10.1016/j.neuropharm.2008.08.001
Du J, 2010, P NATL ACAD SCI USA, V107, P11573, DOI 10.1073/pnas.0913138107
Elliott R, 2011, NEUROPSYCHOPHARMACOL, V36, P153, DOI 10.1038/npp.2010.77
Emamian ES, 2004, NAT GENET, V36, P131, DOI 10.1038/ng1296
Giros B, 1996, NATURE, V379, P606, DOI 10.1038/379606a0
GLOWINSKI J, 1964, NATURE, V204, P1318, DOI 10.1038/2041318a0
Gould TD, 2007, NEUROPSYCHOPHARMACOL, V32, P1321, DOI 10.1038/sj.npp.1301254
Gould TD, 2004, INT J NEUROPSYCHOPH, V7, P387, DOI 10.1017/S1461145704004535
Guitton MJ, 2008, BEHAV BRAIN RES, V191, P148, DOI 10.1016/j.bbr.2008.03.022
Gustavsson A, 2011, EUR NEUROPSYCHOPHARM, V21, P718, DOI 10.1016/j.euroneuro.2011.08.008
Hoeflich KP, 2000, NATURE, V406, P86, DOI 10.1038/35017574
Huang ZJ, 2002, GENESIS, V32, P209, DOI 10.1002/gene.10054
Jones SR, 1998, J NEUROSCI, V18, P1979
Kaidanovich-Beilin O, 2009, MOL BRAIN, V2, DOI 10.1186/1756-6606-2-35
Kaidanovich-Beilin O, 2004, BIOL PSYCHIAT, V55, P781, DOI 10.1016/j.biopsych.2004.01.008
Kapur S, 2001, ANNU REV MED, V52, P503, DOI 10.1146/annurev.med.52.1.503
Kimura T, 2008, PLOS ONE, V3, DOI 10.1371/journal.pone.0003540
Klein PS, 1996, P NATL ACAD SCI USA, V93, P8455, DOI 10.1073/pnas.93.16.8455
Lemmon MA, 2010, CELL, V141, P1117, DOI 10.1016/j.cell.2010.06.011
Lesch KP, 1996, SCIENCE, V274, P1527, DOI 10.1126/science.274.5292.1527
Li XH, 2007, INT J NEUROPSYCHOPH, V10, P7, DOI 10.1017/S1461145706006547
Li XH, 2004, NEUROPSYCHOPHARMACOL, V29, P1426, DOI 10.1038/sj.npp.1300439
Li XH, 2010, NEUROPSYCHOPHARMACOL, V35, P2143, DOI 10.1038/npp.2010.105
Li YC, 2009, J NEUROSCI, V29, P15551, DOI 10.1523/JNEUROSCI.3336-09.2009
Liu HY, 2011, J AM ACAD CHILD PSY, V50, P749, DOI 10.1016/j.jaac.2011.05.011
MELTZER HY, 1991, SCHIZOPHRENIA BULL, V17, P263
Menard J, 1999, NEUROSCI BIOBEHAV R, V23, P591, DOI 10.1016/S0149-7634(98)00056-6
Mines MA, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009706
Moy SS, 2004, GENES BRAIN BEHAV, V3, P287, DOI 10.1111/j.1601-183X.2004.00076.x
Nadler JJ, 2004, GENES BRAIN BEHAV, V3, P303, DOI 10.1111/j.1601-183X.2004.00071.x
Nguyen HT, 2013, BRIT J PHARMACOL, V168, P103, DOI 10.1111/j.1476-5381.2012.01850.x
O'Brien WT, 2004, J NEUROSCI, V24, P6791, DOI 10.1523/JNEUROSCI.4753-03.2004
Patel S, 2008, MOL CELL BIOL, V28, P6314, DOI 10.1128/MCB.00763-08
Patel S, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0015845
Peineau S, 2007, NEURON, V53, P703, DOI 10.1016/j.neuron.2007.01.029
Peineau S, 2008, BRIT J PHARMACOL, V153, pS428, DOI 10.1038/bjp.2008.2
Polter A, 2010, NEUROPSYCHOPHARMACOL, V35, P1761, DOI 10.1038/npp.2010.43
Polter A, 2009, BIOL PSYCHIAT, V65, P150, DOI 10.1016/j.biopsych.2008.08.005
Polter AM, 2012, CELL SIGNAL, V24, P265, DOI 10.1016/j.cellsig.2011.09.009
Prickaerts J, 2006, J NEUROSCI, V26, P9022, DOI 10.1523/JNEUROSCI.5216-05.2006
Ramboz S, 1998, P NATL ACAD SCI USA, V95, P14476, DOI 10.1073/pnas.95.24.14476
Rao JS, 2005, NEUROPSYCHOPHARMACOL, V30, P2006, DOI 10.1038/sj.npp.1300740
Roberts AC, 2011, BIOL PSYCHIAT, V69, P1185, DOI 10.1016/j.biopsych.2010.12.037
Roth BL, 2004, NAT REV DRUG DISCOV, V3, P353, DOI 10.1038/nrd1346
SNYDER SH, 1976, AM J PSYCHIAT, V133, P197
Stambolic V, 1996, CURR BIOL, V6, P1664, DOI 10.1016/S0960-9822(02)70790-2
Takahashi A, 2011, PSYCHOPHARMACOLOGY, V213, P183, DOI 10.1007/s00213-010-2000-y
Walther DJ, 2003, SCIENCE, V299, P76, DOI 10.1126/science.1078197
Weerasinghe GR, 2003, BRAIN RES BULL, V59, P303, DOI 10.1016/S0361-9230(02)00913-9
Wilkinson MB, 2011, J NEUROSCI, V31, P9084, DOI 10.1523/JNEUROSCI.0039-11.2011
Wittchen HU, 2011, EUR NEUROPSYCHOPHARM, V21, P655, DOI 10.1016/j.euroneuro.2011.07.018
York RL, 2008, APPL SPECTROSC, V62, P937
Zhang X, 2010, MOL PSYCHIATR, V16, P1169, DOI DOI 10.1038/MP.2010.99
Zhang XD, 2005, NEURON, V45, P11, DOI 10.1016/j.neuron.2004.12.014
Zhang XD, 2004, SCIENCE, V305, P217, DOI 10.1126/science.1097540
NR 82
TC 17
Z9 17
PU ROYAL SOC
PI LONDON
PA 6-9 CARLTON HOUSE TERRACE, LONDON SW1Y 5AG, ENGLAND
SN 0962-8436
J9 PHILOS T R SOC B
JI Philos. Trans. R. Soc. B-Biol. Sci.
PD SEP 5
PY 2012
VL 367
IS 1601
SI SI
BP 2460
EP 2474
DI 10.1098/rstb.2012.0094
PG 15
WC Biology
SC Life Sciences & Biomedicine - Other Topics
GA 977VY
UT WOS:000306694100008
PM 22826345
ER
PT J
AU Wehman, P
Lau, S
Molinelli, A
Brooke, V
Thompson, K
Moore, C
West, M
AF Wehman, Paul
Lau, Stephanie
Molinelli, Alissa
Brooke, Valerie
Thompson, Katie
Moore, Chandler
West, Michael
TI Supported Employment for Young Adults With Autism Spectrum Disorder:
Preliminary Data
SO RESEARCH AND PRACTICE FOR PERSONS WITH SEVERE DISABILITIES
LA English
DT Article
DE autism spectrum disorder; employment of individuals with ASD;
competitive employment
ID FOLLOW-UP; PROGRAM; COSTS; SERVICES; OUTCOMES; WORK
AB The purpose of this study was to examine the effects of supported employment in securing and maintaining competitive employment for people with autism spectrum disorder, a group that has typically been found to be underemployed or unemployed. This prospective study followed and collected data on 33 individuals with autism spectrum disorder as they progressed through a supported employment model, working one-on-one with an employment specialist. Of the 33 individuals included in the study, 27 successfully obtained competitive employment, with a total of 29 positions secured. The successful results were achieved through the use of a supported employment model and skilled employment specialists who were able to provide a high level of social supports and compensatory training strategies for skill acquisition. Specifically, employment specialists supported individuals through four steps of an individualized supported employment model: (a) the development of a jobseeker profile and assessment, (b) guiding the job development and career search, (c) conducting job site training, and (d) designing long-term supports to promote job retention. The multitude and variance of specific methods and strategies used in each case to execute these key steps of the supported employment model accurately reflect an emphasis on a highly individualized approach. Although the outcomes of this preliminary study were positive in terms of employment outcomes, further research remains to be conducted.
C1 [Wehman, Paul; Lau, Stephanie; Molinelli, Alissa; Brooke, Valerie; Thompson, Katie; Moore, Chandler; West, Michael] Virginia Commonwealth Univ, Rehabil Res & Training Ctr, Richmond, VA 23284 USA.
RP Brooke, V (reprint author), Virginia Commonwealth Univ, Rehabil Res & Training Ctr, 1314 West Main St,POB 842011, Richmond, VA 23284 USA.
EM vbrooke@vcu.edu
CR Alcock J., 2003, EVALUATION PROSPECTS
Attwood Tony, 2006, COMPLETE GUIDE ASPER
Bolman WM, 2008, J AUTISM DEV DISORD, V38, P181, DOI 10.1007/s10803-007-0362-8
Bond GR, 1999, J DISABIL POLICY STU, V10, P18
Brooke V. A., 2009, TEACHING EXCEPTIONAL, V41, P58
Cameto R., 2004, TRANSITION PLANING S
Cimera RE, 2009, AUTISM, V13, P285, DOI 10.1177/1362361309103791
Garcia-Villamisar D, 2000, J VOCATIONAL REHABIL, V14, P183
Garcia-Villamisar D., 2002, J VOCATIONAL REHABIL, V17, P309
Hillier A, 2007, CAREER DEV EXCEPTION, V30, P35, DOI DOI 10.1177/08857288070300010501
Howlin P, 2005, AUTISM, V9, P533, DOI 10.1177/1362361305057871
Howlin P, 2000, AUTISM, V4, P63, DOI DOI 10.1177/1362361300004001005
Howlin P, 2004, J CHILD PSYCHOL PSYC, V45, P212, DOI 10.1111/j.1469-7610.2004.00215.x
Hurlbutt K, 2004, FOCUS AUTISM OTHER D, V19, P215, DOI DOI 10.1177/10883576040190040301
Inge K., 1996, AM REHABIL, V22, P2
Inge K., 2007, Q A CUSTOMIZED EMPLO
Keel JH, 1997, J AUTISM DEV DISORD, V27, P3, DOI 10.1023/A:1025813020229
Lawer L, 2009, J AUTISM DEV DISORD, V39, P487, DOI 10.1007/s10803-008-0649-4
Mawhood L, 2000, J CHILD PSYCHOL PSYC, V41, P547, DOI 10.1017/S002196309900579X
Mawhood L, 1999, AUTISM INT J RES PRA, V3, P229, DOI DOI 10.1177/1362361399003003003
Nesbitt S., 2000, AUTISM, V4, P357, DOI [10. 1177/ 1362361300004004002, DOI 10.1177/1362361300004004002]
Rutkowski S., 2006, J VOCATIONAL REHABIL, V25, P85
Schaller J, 2005, REHABIL COUNS BULL, V49, P4, DOI 10.1177/00343552050490010201
Smith M, 1995, GUIDE SUCCESSFUL EMP
Smith M., 1994, J VOCATIONAL REHABIL, V4, P60
Targett P. S., 2009, AUTISM TRANSITION AD
Wagner M., 2005, HIGH SCH 1 LOOK POST
Wagner M., 2006, OVERVIEW FINDINGS WA
Wehman P, 2009, AUTISM TRANSITION AD
Wehman P., 2007, REAL WORK REAL PAY I
Wehman P., 1998, AM REHABILITATION, V24, P3143
WEHMAN P, 1994, AM J PHYS MED REHAB, V73, P280, DOI 10.1097/00002060-199407000-00010
Wehman P, 1999, EDUC TRAIN MENT RET, V34, P3
Wehman P., 2007, AUTISM ADVOCATE, V46, P54
Wehman R, 1995, J HEAD TRAUMA REHAB, V10, P27
WEST M, 1991, ARCH PHYS MED REHAB, V72, P127
NR 36
TC 3
Z9 3
PU TASH
PI WASHINGTON
PA 1025 VERMONT AVE, NW 7TH FLR, WASHINGTON, DC 20005 USA
SN 0274-9483
J9 RES PRACT PERS SEV D
JI Res. Pract. Pers. Sev. Disabil.
PD FAL
PY 2012
VL 37
IS 3
BP 160
EP 169
PG 10
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA 176OU
UT WOS:000321314800004
ER
PT J
AU Walker, VL
AF Walker, Virginia L.
TI Jumpstarting Communication Skills in Children With Autism: A Parents'
Guide to Applied Verbal Behavior
SO RESEARCH AND PRACTICE FOR PERSONS WITH SEVERE DISABILITIES
LA English
DT Book Review
C1 [Walker, Virginia L.] Univ Virginia, Charlottesville, VA 22903 USA.
RP Walker, VL (reprint author), Univ Virginia, Charlottesville, VA 22903 USA.
CR American Speech-Language-Hearing Association, 2012, AUGMENTATIVE ALTERNA
Ganz JB, 2008, RES AUTISM SPECT DIS, V2, P157, DOI 10.1016/j.rasd.2007.04.005
WEISS MJ, 2011, JUMPSTARTING COMMUNI
NR 3
TC 0
Z9 0
PU TASH
PI WASHINGTON
PA 1025 VERMONT AVE, NW 7TH FLR, WASHINGTON, DC 20005 USA
SN 0274-9483
J9 RES PRACT PERS SEV D
JI Res. Pract. Pers. Sev. Disabil.
PD FAL
PY 2012
VL 37
IS 3
BP 230
EP 231
PG 2
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA 176OU
UT WOS:000321314800014
ER
PT J
AU DeGutis, J
Cohan, S
Mercado, RJ
Wilmer, J
Nakayama, K
AF DeGutis, Joseph
Cohan, Sarah
Mercado, Rogelio J.
Wilmer, Jeremy
Nakayama, Ken
TI Holistic processing of the mouth but not the eyes in developmental
prosopagnosia
SO COGNITIVE NEUROPSYCHOLOGY
LA English
DT Article
DE Developmental prosopagnosia; Holistic face processing; Partwhole task
ID FACE RECOGNITION ABILITY; AUTISM SPECTRUM DISORDERS; UPSIDE-DOWN FACES;
ACQUIRED PROSOPAGNOSIA; CONGENITAL PROSOPAGNOSIA; FUNCTIONING AUTISM;
INDIVIDUAL FACES; INVERSION LEADS; PERCEPTION; EXPERTISE
AB Because holistic processing is a hallmark of normal face recognition, we ask whether such processing is reduced in developmental prosopagnosia (DP), and, if so, what the sources are of this deficit. Existing literature provides a mixed picture, with face inversion effects showing consistent holistic processing deficits but unable to locate their source and with some composite face studies showing reduced holistic processing and some not. We addressed this issue more thoroughly with a very large sample of DPs (N = 38) performing the partwhole task, a well-accepted measure of holistic processing that allows for the separate evaluation of individual face parts. Contrary to an expected overall reduction in holistic processing, we found an intact holistic advantage for the mouth and a complete absence of a holistic advantage for the eye region. Less severely impaired prosopagnosics showed significantly more holistic processing of the mouth, suggesting that holistic processing can aid them in recognizing faces.
C1 [DeGutis, Joseph] Boston VA Healthcare Syst, Geriatr Res Educ & Clin Ctr, Jamaica Plain, MA 02130 USA.
[DeGutis, Joseph; Cohan, Sarah; Nakayama, Ken] Harvard Univ, Dept Psychol, Vis Sci Lab, Cambridge, MA 02138 USA.
[Mercado, Rogelio J.] Temple Univ, Dept Psychol, Philadelphia, PA 19122 USA.
[Wilmer, Jeremy] Wellesley Coll, Dept Psychol, Wellesley, MA 02181 USA.
RP DeGutis, J (reprint author), Boston VA Healthcare Syst, Geriatr Res Educ & Clin Ctr, Jamaica Plain, MA 02130 USA.
EM degutis@wjh.harvard.edu
FU Veterans Affairs Career Development Award; National Institutes of Health
[5R01EY013602-07]
FX We would like to thank all the developmental prosopagnosics and control
participants for contributing their time and effort. We would also like
to thank Sam Anthony, Anne Grossetete, and Long Ouyang for programming
the tasks. Finally, we would like to acknowledge funding support from a
Veterans Affairs Career Development Award for J.D. and a grant from the
National Institutes of Health 5R01EY013602-07 awarded to K.N.
Contributions: J.D. performed data analysis, wrote the manuscript, and
contributed funding. S.C. recruited and tested developmental
prosopagnosics, performed data analysis, and contributed to manuscript
preparation. R.M. recruited and tested control subjects, performed data
analysis, and contributed to manuscript preparation. J.W. helped with
data analysis and contributed to manuscript preparation. K.N.
contributed to manuscript preparation and contributed funding.
CR Andrews TJ, 2010, J NEUROSCI, V30, P3544, DOI 10.1523/JNEUROSCI.4863-09.2010
ATTNEAVE F, 1967, J EXP PSYCHOL, V74, P149, DOI 10.1037/h0024557
Avidan G, 2011, NEUROPSYCHOLOGIA, V49, P2541, DOI 10.1016/j.neuropsychologia.2011.05.002
Baron-Cohen S, 2001, J AUTISM DEV DISORD, V31, P5, DOI 10.1023/A:1005653411471
BARTLETT JC, 1993, COGNITIVE PSYCHOL, V25, P281, DOI 10.1006/cogp.1993.1007
Barton JJS, 2003, BRAIN COGNITION, V51, P12, DOI 10.1016/S0278-2626(02)00516-X
Behrmann M, 2005, J COGNITIVE NEUROSCI, V17, P1130, DOI 10.1162/0898929054475154
Bukach CM, 2008, J NEUROPSYCHOL, V2, P227, DOI 10.1348/174866407X231010
Busigny T, 2010, CORTEX, V46, P965, DOI 10.1016/j.cortex.2009.07.004
Busigny T, 2010, NEUROPSYCHOLOGIA, V48, P4057, DOI 10.1016/j.neuropsychologia.2010.09.017
Butler S, 2010, ATTEN PERCEPT PSYCHO, V72, P1444, DOI 10.3758/APP.72.6.1444
Caldara R, 2005, J COGNITIVE NEUROSCI, V17, P1652, DOI 10.1162/089892905774597254
Cassia VM, 2009, DEVELOPMENTAL SCI, V12, P236, DOI 10.1111/j.1467-7687.2008.00765.x
Curby KM, 2007, PSYCHON B REV, V14, P620, DOI 10.3758/BF03196811
Dalton KM, 2005, NAT NEUROSCI, V8, P519, DOI 10.1038/nn1421
DAVIDOFF J, 1990, ACTA PSYCHOL, V73, P225, DOI 10.1016/0001-6918(90)90024-A
Davidoff J., 1986, ASPECTS FACE PROCESS, P279
de Gelder B, 2000, NEUROREPORT, V11, P3145, DOI 10.1097/00001756-200009280-00021
DeGutis J., 2012, FACE GENDER RE UNPUB
DeGutis J, 2011, NEUROPSYCHOLOGIA, V49, P2505, DOI 10.1016/j.neuropsychologia.2011.04.031
DeGutis J, 2013, COGNITION, V126, P87, DOI 10.1016/j.cognition.2012.09.004
de Xivry JJO, 2008, J NEUROPSYCHOL, V2, P245, DOI 10.1348/174866407X260199
DIAMOND R, 1986, J EXP PSYCHOL GEN, V115, P107, DOI 10.1037/0096-3445.115.2.107
Duchaine B, 2007, COGN NEUROPSYCHOL, V24, P419, DOI 10.1080/02643290701380491
Duchaine B, 2009, COGN NEUROPSYCHOL, V26, P620, DOI 10.1080/02643291003616145
Duchaine B, 2006, NEUROPSYCHOLOGIA, V44, P576, DOI 10.1016/j.neuropsychologia.2005.07.001
Duchaine BC, 2006, CURR OPIN NEUROBIOL, V16, P166, DOI 10.1016/j.conb.2006.03.003
Duchaine BC, 2006, COGN NEUROPSYCHOL, V23, P714, DOI 10.1080/02643290500441296
Faja S, 2009, J AUTISM DEV DISORD, V39, P532, DOI 10.1007/s10803-008-0635-x
Farah MJ, 1998, PSYCHOL REV, V105, P482, DOI 10.1037//0033-295X.105.3.482
FARAH MJ, 1995, VISION RES, V35, P2089, DOI 10.1016/0042-6989(94)00273-O
Garner W. R., 1974, PROCESSING INFORM ST
Garrido L, 2008, J NEUROPSYCHOL, V2, P119, DOI 10.1348/174866407X246843
Germine L, 2012, PSYCHON B REV, V19, P847, DOI 10.3758/s13423-012-0296-9
HOLE GJ, 1994, PERCEPTION, V23, P65, DOI 10.1068/p230065
Hsiao JHW, 2008, PSYCHOL SCI, V19, P998, DOI 10.1111/j.1467-9280.2008.02191.x
Ingvalson EM, 2005, PERCEPT PSYCHOPHYS, V67, P14, DOI 10.3758/BF03195010
Jacques C, 2009, J VISION, V9, DOI 10.1167/9.6.8
Joseph RM, 2003, J CHILD PSYCHOL PSYC, V44, P529, DOI 10.1111/1469-7610.00142
Kohler W., 1940, DYNAMICS PSYCHOL
Lee Y, 2010, CORTEX, V46, P949, DOI 10.1016/j.cortex.2009.07.012
Le Grand R, 2006, BRAIN COGNITION, V61, P139, DOI 10.1016/j.bandc.2005.11.005
Maurer D, 2002, TRENDS COGN SCI, V6, P255, DOI 10.1016/S1364-6613(02)01903-4
McKone E, 2009, PSYCHON B REV, V16, P778, DOI 10.3758/PBR.16.5.778
McKone E, 2007, COGNITION, V103, P331, DOI 10.1016/j.cognition.2006.05.014
Minnebusch DA, 2007, EUR J NEUROSCI, V25, P2234, DOI 10.1111/j.1460-9568.2007.05451.x
Nunn JA, 2001, NEUROCASE, V7, P15, DOI 10.1093/neucas/7.1.15
Palermo R, 2011, NEUROPSYCHOLOGIA, V49, P1226, DOI 10.1016/j.neuropsychologia.2011.02.021
Pitcher D, 2009, CURR BIOL, V19, P319, DOI 10.1016/j.cub.2009.01.007
Ramon M, 2010, NEUROPSYCHOLOGIA, V48, P933, DOI 10.1016/j.neuropsychologia.2009.11.014
Ramon M, 2010, CORTEX, V46, P374, DOI 10.1016/j.cortex.2009.06.001
RHODES G, 1993, COGNITION, V47, P25, DOI 10.1016/0010-0277(93)90061-Y
Richler JJ, 2011, PSYCHOL SCI, V22, P464, DOI 10.1177/0956797611401753
Richler JJ, 2008, J EXP PSYCHOL LEARN, V34, P1356, DOI 10.1037/a0013080
RIDDOCH MJ, 1987, BRAIN, V110, P1431, DOI 10.1093/brain/110.6.1431
Righart R, 2007, P NATL ACAD SCI USA, V104, P17234, DOI 10.1073/pnas.0707753104
Rivolta Davide, 2012, Front Hum Neurosci, V6, P45, DOI 10.3389/fnhum.2012.00045
Robbins R, 2007, COGNITION, V103, P34, DOI 10.1016/j.cognition.2006.02.008
Rossion B, 2008, ACTA PSYCHOL, V128, P274, DOI 10.1016/j.actpsy.2008.02.003
Rossion B., 2010, J VISION, V1, P10
Rossion B, 2009, J NEUROPSYCHOL, V3, P69, DOI 10.1348/174866408X289944
Rossion B, 2009, ACTA PSYCHOL, V132, P300, DOI 10.1016/j.actpsy.2009.08.002
Rossion B, 2002, PSYCHOL SCI, V13, P250, DOI 10.1111/1467-9280.00446
Russell R, 2009, PSYCHON B REV, V16, P252, DOI 10.3758/PBR.16.2.252
Schiltz C., 2010, J VISION, V10, p[25, 21]
Schmalzl L, 2009, COGN NEUROPSYCHOL, V26, P286, DOI 10.1080/02643290903086904
Schmalzl L, 2008, J NEUROPSYCHOL, V2, P99, DOI 10.1348/174866407X256554
Schyns PG, 2002, PSYCHOL SCI, V13, P402, DOI 10.1111/1467-9280.00472
Seitz K, 2002, J EXP CHILD PSYCHOL, V82, P367, DOI 10.1016/S0022-0965(02)00106-6
Sekuler AB, 2004, CURR BIOL, V14, P391, DOI 10.1016/j.cub.2004.02.028
Susilo T, 2010, COGN NEUROPSYCHOL, V27, P636, DOI 10.1080/02643294.2011.613372
TANAKA JW, 1993, Q J EXP PSYCHOL-A, V46, P225
Tanaka JW, 2004, COGNITION, V93, pB1, DOI 10.1016/j.cognition.2003.09.011
Todorov A, 2010, PERCEPTION, V39, P514, DOI 10.1068/p6501
Tree JJ, 2010, CORTEX, V46, P1189, DOI 10.1016/j.cortex.2010.03.005
VALENTINE T, 1988, BRIT J PSYCHOL, V79, P471
Van den Stock J, 2008, PLOS ONE, V3, DOI 10.1371/journal.pone.0003195
Vinette C, 2004, COGNITIVE SCI, V28, P289, DOI 10.1016/j.cogsci.2004.01.002
Wang RS, 2012, PSYCHOL SCI, V23, P169, DOI 10.1177/0956797611420575
Weigelt S, 2012, NEUROSCI BIOBEHAV R, V36, P1060, DOI 10.1016/j.neubiorev.2011.12.008
Wilmer JB, 2010, P NATL ACAD SCI USA, V107, P5238, DOI 10.1073/pnas.0913053107
Wong ACN, 2009, PSYCHOL SCI, V20, P1108, DOI 10.1111/j.1467-9280.2009.02430.x
Xu YD, 2005, NEUROPSYCHOLOGIA, V43, P588, DOI 10.1016/j.neuropsychologia.2004.07.016
YIN RK, 1969, J EXP PSYCHOL, V81, P141, DOI 10.1037/h0027474
Young A. M., 1987, PERCEPTION, V10, P747, DOI DOI 10.1068/P160747
Yovel G, 2009, ACTA PSYCHOL, V132, P293, DOI 10.1016/j.actpsy.2009.07.009
Yovel G, 2006, J COGNITIVE NEUROSCI, V18, P580, DOI 10.1162/jocn.2006.18.4.580
Yovel G, 2005, VIS COGN, V12, P337, DOI 10.1080/13506280444000210
Yovel G, 2010, J EXP PSYCHOL HUMAN, V36, P759, DOI 10.1037/a0017451
NR 89
TC 9
Z9 9
PU PSYCHOLOGY PRESS
PI HOVE
PA 27 CHURCH RD, HOVE BN3 2FA, EAST SUSSEX, ENGLAND
SN 0264-3294
J9 COGN NEUROPSYCHOL
JI Cogn. Neuropsychol.
PD SEP 1
PY 2012
VL 29
IS 5-6
SI SI
BP 419
EP 446
DI 10.1080/02643294.2012.754745
PG 28
WC Psychology; Psychology, Experimental
SC Psychology
GA 095PB
UT WOS:000315345400005
PM 23428080
ER
PT J
AU Benning, SD
Sabatino, A
Franklin, JC
Sasson, NJ
Bodfish, JW
Dichter, GS
AF Benning, Stephen D.
Sabatino, Anna
Franklin, Joseph C.
Sasson, Noah J.
Bodfish, James W.
Dichter, Gabriel S.
TI STARTLE BLINK MODULATION DURING CIRCUMSCRIBED INTEREST AND FACE STIMULI
IN AUTISM SPECTRUM DISORDER
SO PSYCHOPHYSIOLOGY
LA English
DT Meeting Abstract
CT 52nd Annual Meeting of the Society-for-Psychophysiological-Research
CY SEP 19-23, 2012
CL New Orleans, LA
SP Soc Psychophysiol Res
DE startle; autism; circumscribed interests
C1 [Benning, Stephen D.] Univ Nevada, Las Vegas, NV 89154 USA.
[Sabatino, Anna; Franklin, Joseph C.; Sasson, Noah J.; Bodfish, James W.; Dichter, Gabriel S.] Univ N Carolina, Chapel Hill, NC USA.
NR 0
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0048-5772
J9 PSYCHOPHYSIOLOGY
JI Psychophysiology
PD SEP
PY 2012
VL 49
SU 1
SI SI
BP S50
EP S50
PG 1
WC Psychology, Biological; Neurosciences; Physiology; Psychology;
Psychology, Experimental
SC Psychology; Neurosciences & Neurology; Physiology
GA 080VN
UT WOS:000314272300278
ER
PT J
AU Dominguez, L
Stieben, J
Velazquez, J
AF Dominguez, Luis
Stieben, Jim
Velazquez, Jose
TI IMAGINARY COHERENCE AS A BIOMARKER OF AUTISM
SO PSYCHOPHYSIOLOGY
LA English
DT Meeting Abstract
CT 52nd Annual Meeting of the Society-for-Psychophysiological-Research
CY SEP 19-23, 2012
CL New Orleans, LA
SP Soc Psychophysiol Res
C1 [Dominguez, Luis; Stieben, Jim] York Univ, N York, ON M3J 1P3, Canada.
[Velazquez, Jose] Univ Toronto, Toronto, ON M5S 1A1, Canada.
NR 0
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0048-5772
J9 PSYCHOPHYSIOLOGY
JI Psychophysiology
PD SEP
PY 2012
VL 49
SU 1
SI SI
BP S9
EP S9
PG 1
WC Psychology, Biological; Neurosciences; Physiology; Psychology;
Psychology, Experimental
SC Psychology; Neurosciences & Neurology; Physiology
GA 080VN
UT WOS:000314272300046
ER
PT J
AU Gayle, LC
Kieffaber, PD
AF Gayle, Leigh C.
Kieffaber, Paul D.
TI THE EFFECT OF AUTISM SPECTRUM PERSONALITY ON THE VISUAL MISMATCH
NEGATIVITY
SO PSYCHOPHYSIOLOGY
LA English
DT Meeting Abstract
CT 52nd Annual Meeting of the Society-for-Psychophysiological-Research
CY SEP 19-23, 2012
CL New Orleans, LA
SP Soc Psychophysiol Res
DE Mismatch Negativity; Emotion; Autism
C1 [Gayle, Leigh C.; Kieffaber, Paul D.] Coll William & Mary, Williamsburg, VA 23187 USA.
NR 0
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0048-5772
J9 PSYCHOPHYSIOLOGY
JI Psychophysiology
PD SEP
PY 2012
VL 49
SU 1
SI SI
BP S27
EP S27
PG 1
WC Psychology, Biological; Neurosciences; Physiology; Psychology;
Psychology, Experimental
SC Psychology; Neurosciences & Neurology; Physiology
GA 080VN
UT WOS:000314272300153
ER
PT J
AU Hensley, MK
El-Baz, AS
Sokhadze, GE
Sears, L
Casanova, MF
Sokhadze, EM
AF Hensley, Marie K.
El-Baz, Ayman S.
Sokhadze, Guela E.
Sears, Lonnie
Casanova, Manuel F.
Sokhadze, Estate M.
TI TMS EFFECTS ON CARDIAC AUTONOMIC CONTROL IN CHILDREN WITH AUTISM
SO PSYCHOPHYSIOLOGY
LA English
DT Meeting Abstract
CT 52nd Annual Meeting of the Society-for-Psychophysiological-Research
CY SEP 19-23, 2012
CL New Orleans, LA
SP Soc Psychophysiol Res
DE Autism; Heart rate; TMS
C1 [Hensley, Marie K.; El-Baz, Ayman S.; Sokhadze, Guela E.; Sears, Lonnie; Casanova, Manuel F.; Sokhadze, Estate M.] Univ Louisville, Louisville, KY 40292 USA.
NR 0
TC 1
Z9 1
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0048-5772
J9 PSYCHOPHYSIOLOGY
JI Psychophysiology
PD SEP
PY 2012
VL 49
SU 1
SI SI
BP S40
EP S40
PG 1
WC Psychology, Biological; Neurosciences; Physiology; Psychology;
Psychology, Experimental
SC Psychology; Neurosciences & Neurology; Physiology
GA 080VN
UT WOS:000314272300223
ER
PT J
AU Lerner, MD
Morris, JP
McPartland, JC
AF Lerner, Matthew D.
Morris, James P.
McPartland, James C.
TI PROCESSING OF EMOTIONAL FACES AND VOICES IN AUTISM SPECTRUM DISORDERS:
ERP CORRELATES AND INTERACTION WITH SOCIAL KNOWLEDGE
SO PSYCHOPHYSIOLOGY
LA English
DT Meeting Abstract
CT 52nd Annual Meeting of the Society-for-Psychophysiological-Research
CY SEP 19-23, 2012
CL New Orleans, LA
SP Soc Psychophysiol Res
C1 [Lerner, Matthew D.; Morris, James P.] Univ Virginia, Charlottesville, VA 22903 USA.
[McPartland, James C.] Yale Univ, Ctr Child Study, New Haven, CT 06520 USA.
NR 0
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0048-5772
J9 PSYCHOPHYSIOLOGY
JI Psychophysiology
PD SEP
PY 2012
VL 49
SU 1
SI SI
BP S7
EP S7
PG 1
WC Psychology, Biological; Neurosciences; Physiology; Psychology;
Psychology, Experimental
SC Psychology; Neurosciences & Neurology; Physiology
GA 080VN
UT WOS:000314272300033
ER
PT J
AU Lewis, GF
McCue, K
Stanfill, S
Macellaio, M
Porges, SW
AF Lewis, Gregory F.
McCue, Kimberly
Stanfill, Shannon
Macellaio, Matthew
Porges, Stephen W.
TI AUTONOMIC REACTIVITY AND AUDITORY PROCESSING COVARY IN AUTISM
SO PSYCHOPHYSIOLOGY
LA English
DT Meeting Abstract
CT 52nd Annual Meeting of the Society-for-Psychophysiological-Research
CY SEP 19-23, 2012
CL New Orleans, LA
SP Soc Psychophysiol Res
C1 [Lewis, Gregory F.; Porges, Stephen W.] Res Triangle Inst Int, Res Triangle Pk, NC USA.
[McCue, Kimberly; Stanfill, Shannon; Macellaio, Matthew] Univ Illinois, Chicago, IL USA.
NR 0
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0048-5772
J9 PSYCHOPHYSIOLOGY
JI Psychophysiology
PD SEP
PY 2012
VL 49
SU 1
SI SI
BP S7
EP S7
PG 1
WC Psychology, Biological; Neurosciences; Physiology; Psychology;
Psychology, Experimental
SC Psychology; Neurosciences & Neurology; Physiology
GA 080VN
UT WOS:000314272300034
ER
PT J
AU Louwerse, A
van der Geest, JN
Tulen, JH
Verhulst, FC
Greaves-Lord, K
AF Louwerse, Anneke
van der Geest, Jos N.
Tulen, Joke H.
Verhulst, Frank C.
Greaves-Lord, Kirstin
TI GAZE BEHAVIOR AND SKIN CONDUCTANCE ACTIVITY IN REACTION TO EYES IN
ADOLESCENTS WITH AUTISM SPECTRUM DISORDERS
SO PSYCHOPHYSIOLOGY
LA English
DT Meeting Abstract
CT 52nd Annual Meeting of the Society-for-Psychophysiological-Research
CY SEP 19-23, 2012
CL New Orleans, LA
SP Soc Psychophysiol Res
C1 [Louwerse, Anneke; van der Geest, Jos N.; Tulen, Joke H.; Verhulst, Frank C.; Greaves-Lord, Kirstin] Erasmus MC, Rotterdam, Netherlands.
NR 0
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0048-5772
J9 PSYCHOPHYSIOLOGY
JI Psychophysiology
PD SEP
PY 2012
VL 49
SU 1
SI SI
BP S26
EP S26
PG 1
WC Psychology, Biological; Neurosciences; Physiology; Psychology;
Psychology, Experimental
SC Psychology; Neurosciences & Neurology; Physiology
GA 080VN
UT WOS:000314272300149
ER
PT J
AU Mathewson, KJ
Jetha, MK
Drmic, IE
Bryson, SE
Goldberg, JO
Schmidt, LA
AF Mathewson, Karen J.
Jetha, Michelle K.
Drmic, Irene E.
Bryson, Susan E.
Goldberg, Joel O.
Schmidt, Louis A.
TI RELATIONS BETWEEN BEHAVIOURAL SYMPTOMATOLOGY AND REGIONAL EEG ALPHA
POWER AND COHERENCE IN ADULTS WITH AUTISM SPECTRUM DISORDER
SO PSYCHOPHYSIOLOGY
LA English
DT Meeting Abstract
CT 52nd Annual Meeting of the Society-for-Psychophysiological-Research
CY SEP 19-23, 2012
CL New Orleans, LA
SP Soc Psychophysiol Res
C1 [Mathewson, Karen J.; Goldberg, Joel O.; Schmidt, Louis A.] McMaster Univ, Hamilton, ON L8S 4L8, Canada.
[Jetha, Michelle K.] Brock Univ, St Catharines, ON L2S 3A1, Canada.
[Drmic, Irene E.] York Univ, N York, ON M3J 1P3, Canada.
[Bryson, Susan E.] Dalhousie Univ, Halifax, NS B3H 3J5, Canada.
NR 0
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0048-5772
J9 PSYCHOPHYSIOLOGY
JI Psychophysiology
PD SEP
PY 2012
VL 49
SU 1
SI SI
BP S9
EP S9
PG 1
WC Psychology, Biological; Neurosciences; Physiology; Psychology;
Psychology, Experimental
SC Psychology; Neurosciences & Neurology; Physiology
GA 080VN
UT WOS:000314272300045
ER
PT J
AU Monk, CS
Swartz, JR
Wiggins, JL
Carrasco, M
Lord, C
AF Monk, Christopher S.
Swartz, Johnna R.
Wiggins, Jillian L.
Carrasco, Melisa
Lord, Catherine
TI AMYGDALA ACTIVATION AND PREFRONTAL CORTEX FUNCTIONAL CONNECTIVITY IN
YOUTH WITH AUTISM SPECTRUM DISORDERS
SO PSYCHOPHYSIOLOGY
LA English
DT Meeting Abstract
CT 52nd Annual Meeting of the Society-for-Psychophysiological-Research
CY SEP 19-23, 2012
CL New Orleans, LA
SP Soc Psychophysiol Res
C1 [Monk, Christopher S.; Swartz, Johnna R.; Wiggins, Jillian L.; Carrasco, Melisa; Lord, Catherine] Univ Michigan, Ann Arbor, MI 48109 USA.
RI Monk, Christopher/J-1805-2014
NR 0
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0048-5772
J9 PSYCHOPHYSIOLOGY
JI Psychophysiology
PD SEP
PY 2012
VL 49
SU 1
SI SI
BP S4
EP S4
PG 1
WC Psychology, Biological; Neurosciences; Physiology; Psychology;
Psychology, Experimental
SC Psychology; Neurosciences & Neurology; Physiology
GA 080VN
UT WOS:000314272300017
ER
PT J
AU Patriquin, MA
Scarpa, A
Friedman, BH
White, SW
Kishida, KT
AF Patriquin, Michelle A.
Scarpa, Angela
Friedman, Bruce H.
White, Susan W.
Kishida, Kenneth T.
TI AUTISM SPECTRUM DISORDERS THROUGH A NEUROPHYSIOLOGICAL LENS
SO PSYCHOPHYSIOLOGY
LA English
DT Meeting Abstract
CT 52nd Annual Meeting of the Society-for-Psychophysiological-Research
CY SEP 19-23, 2012
CL New Orleans, LA
SP Soc Psychophysiol Res
C1 [Patriquin, Michelle A.; Scarpa, Angela; Friedman, Bruce H.; White, Susan W.] Virginia Tech, Blacksburg, VA USA.
[Kishida, Kenneth T.] Virginia Tech, Caril Res Inst, Blacksburg, VA USA.
NR 0
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0048-5772
J9 PSYCHOPHYSIOLOGY
JI Psychophysiology
PD SEP
PY 2012
VL 49
SU 1
SI SI
BP S7
EP S7
PG 1
WC Psychology, Biological; Neurosciences; Physiology; Psychology;
Psychology, Experimental
SC Psychology; Neurosciences & Neurology; Physiology
GA 080VN
UT WOS:000314272300035
ER
PT J
AU Schaaf, RC
Benevides, TW
AF Schaaf, Roseann C.
Benevides, Teal W.
TI BEHAVIORAL AND AUTONOMIC NERVOUS SYSTEM MARKERS OF SENSORY REACTIVITY IN
AUTISM
SO PSYCHOPHYSIOLOGY
LA English
DT Meeting Abstract
CT 52nd Annual Meeting of the Society-for-Psychophysiological-Research
CY SEP 19-23, 2012
CL New Orleans, LA
SP Soc Psychophysiol Res
DE Autism; Sensory; Autonomic
C1 [Schaaf, Roseann C.; Benevides, Teal W.] Thomas Jefferson Univ, Philadelphia, PA USA.
NR 0
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0048-5772
J9 PSYCHOPHYSIOLOGY
JI Psychophysiology
PD SEP
PY 2012
VL 49
SU 1
SI SI
BP S117
EP S117
PG 1
WC Psychology, Biological; Neurosciences; Physiology; Psychology;
Psychology, Experimental
SC Psychology; Neurosciences & Neurology; Physiology
GA 080VN
UT WOS:000314272300627
ER
PT J
AU Sokhadze, EM
Kaplan, M
Edelson, SM
Kotsamanidis, B
Hensley, MK
Sokhadze, GE
Dombroski, B
Casanova, MF
AF Sokhadze, Estate M.
Kaplan, Melvin
Edelson, Stephen M.
Kotsamanidis, Barbara
Hensley, Marie K.
Sokhadze, Guela E.
Dombroski, Brynn
Casanova, Manuel F.
TI AMBIENT PRISM LENSES AFFECT AUTONOMIC REACTIVITY AND ATTENTION TO
AUDIO-VISUAL STIMULI IN AUTISM
SO PSYCHOPHYSIOLOGY
LA English
DT Meeting Abstract
CT 52nd Annual Meeting of the Society-for-Psychophysiological-Research
CY SEP 19-23, 2012
CL New Orleans, LA
SP Soc Psychophysiol Res
DE Autism; Heart Rate; Skin Conductance Level
C1 [Sokhadze, Estate M.; Hensley, Marie K.; Sokhadze, Guela E.; Dombroski, Brynn; Casanova, Manuel F.] Univ Louisville, Louisville, KY 40292 USA.
[Kaplan, Melvin; Kotsamanidis, Barbara] Ctr Visual Management, New York, NY USA.
[Edelson, Stephen M.] Autism Res Inst, San Diego, CA USA.
NR 0
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0048-5772
J9 PSYCHOPHYSIOLOGY
JI Psychophysiology
PD SEP
PY 2012
VL 49
SU 1
SI SI
BP S40
EP S40
PG 1
WC Psychology, Biological; Neurosciences; Physiology; Psychology;
Psychology, Experimental
SC Psychology; Neurosciences & Neurology; Physiology
GA 080VN
UT WOS:000314272300224
ER
PT J
AU Stieben, J
Dominguez, L
AF Stieben, Jim
Dominguez, Luis
TI TREATMENT RELATED CHANGES IN CORTICAL CONNECTIVITY IN FACE/EMOTION
PROCESSING WITH PRESCHOOL AGE CHILDREN WITH AUTISM
SO PSYCHOPHYSIOLOGY
LA English
DT Meeting Abstract
CT 52nd Annual Meeting of the Society-for-Psychophysiological-Research
CY SEP 19-23, 2012
CL New Orleans, LA
SP Soc Psychophysiol Res
DE EEG Cortical Coherence; Autism
C1 [Stieben, Jim; Dominguez, Luis] York Univ, N York, ON M3J 1P3, Canada.
NR 0
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0048-5772
J9 PSYCHOPHYSIOLOGY
JI Psychophysiology
PD SEP
PY 2012
VL 49
SU 1
SI SI
BP S117
EP S117
PG 1
WC Psychology, Biological; Neurosciences; Physiology; Psychology;
Psychology, Experimental
SC Psychology; Neurosciences & Neurology; Physiology
GA 080VN
UT WOS:000314272300628
ER
PT J
AU Stieben, J
Dominguez, L
AF Stieben, Jim
Dominguez, Luis
TI TREATMENT-RELATED CHANGES IN EEG CONNECTIVITY IN PRESCHOOL CHILDREN WITH
AUTISM
SO PSYCHOPHYSIOLOGY
LA English
DT Meeting Abstract
CT 52nd Annual Meeting of the Society-for-Psychophysiological-Research
CY SEP 19-23, 2012
CL New Orleans, LA
SP Soc Psychophysiol Res
C1 [Stieben, Jim; Dominguez, Luis] York Univ, N York, ON M3J 1P3, Canada.
NR 0
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0048-5772
J9 PSYCHOPHYSIOLOGY
JI Psychophysiology
PD SEP
PY 2012
VL 49
SU 1
SI SI
BP S8
EP S8
PG 1
WC Psychology, Biological; Neurosciences; Physiology; Psychology;
Psychology, Experimental
SC Psychology; Neurosciences & Neurology; Physiology
GA 080VN
UT WOS:000314272300043
ER
PT J
AU Worsham, WA
South, M
Larson, MJ
AF Worsham, Whitney A.
South, Mikle
Larson, Michael J.
TI EVENT-RELATED POTENTIAL CORRELATES OF AFFECTIVE PICTURE DIFFERENTIATION
IN HIGH-FUNCTIONING AUTISM SPECTRUM DISORDERS (ASD)
SO PSYCHOPHYSIOLOGY
LA English
DT Meeting Abstract
CT 52nd Annual Meeting of the Society-for-Psychophysiological-Research
CY SEP 19-23, 2012
CL New Orleans, LA
SP Soc Psychophysiol Res
DE autism spectrum disorders; emotion differentiation
C1 [Worsham, Whitney A.; South, Mikle; Larson, Michael J.] Brigham Young Univ, Provo, UT 84602 USA.
NR 0
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0048-5772
J9 PSYCHOPHYSIOLOGY
JI Psychophysiology
PD SEP
PY 2012
VL 49
SU 1
SI SI
BP S85
EP S85
PG 1
WC Psychology, Biological; Neurosciences; Physiology; Psychology;
Psychology, Experimental
SC Psychology; Neurosciences & Neurology; Physiology
GA 080VN
UT WOS:000314272300460
ER
PT J
AU [Anonymous]
AF [Anonymous]
TI NEW DEVELOPMENTS IN THE PSYCHOPHYSIOLOGY OF AUTISM SPECTRUM DISORDERS
SO PSYCHOPHYSIOLOGY
LA English
DT Meeting Abstract
CT 52nd Annual Meeting of the Society-for-Psychophysiological-Research
CY SEP 19-23, 2012
CL New Orleans, LA
SP Soc Psychophysiol Res
NR 0
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0048-5772
J9 PSYCHOPHYSIOLOGY
JI Psychophysiology
PD SEP
PY 2012
VL 49
SU 1
SI SI
BP S6
EP S7
PG 2
WC Psychology, Biological; Neurosciences; Physiology; Psychology;
Psychology, Experimental
SC Psychology; Neurosciences & Neurology; Physiology
GA 080VN
UT WOS:000314272300032
ER
PT J
AU [Anonymous]
AF [Anonymous]
TI EEG CONNECTIVITY AND AUTISM: METHODOLOGICAL AND CLINICAL FEATURES
SO PSYCHOPHYSIOLOGY
LA English
DT Meeting Abstract
CT 52nd Annual Meeting of the Society-for-Psychophysiological-Research
CY SEP 19-23, 2012
CL New Orleans, LA
SP Soc Psychophysiol Res
NR 0
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0048-5772
J9 PSYCHOPHYSIOLOGY
JI Psychophysiology
PD SEP
PY 2012
VL 49
SU 1
SI SI
BP S8
EP S8
PG 1
WC Psychology, Biological; Neurosciences; Physiology; Psychology;
Psychology, Experimental
SC Psychology; Neurosciences & Neurology; Physiology
GA 080VN
UT WOS:000314272300042
ER
PT J
AU Al-Eithan, MH
Al Juban, HA
Robert, AA
AF Al-Eithan, Muwafak H.
Al Juban, Hathab A.
Robert, Asirvatham A.
TI Alexithymia among Arab mothers of disabled children and its correlation
with mood disorders
SO SAUDI MEDICAL JOURNAL
LA English
DT Article
ID DEVELOPMENTAL-DISABILITIES; RETARDED-CHILDREN; EATING-DISORDERS;
MENTAL-HEALTH; PARENTS; DEPRESSION; AUTISM; SCALE; STABILITY; SYMPTOMS
AB Objectives: To study alexithymia among mothers with disabled children in Saudi Arabia, and to explore if alexithymia is associated to their mood difficulties, and certain demographic variables.
Methods: We conducted a prospective study during January 2011 to April 2012, on 86 mothers (study group) caring for children with physical, mental, or sensory disabilities treated at a major tertiary rehabilitation hospital in Riyadh, Saudi Arabia. A total of 32 mothers (control group) with healthy children were also included. The Hospital Anxiety and Depression Scale (HADS) was used to measure the mood symptoms of mothers. The Toronto Alexithymia Scale (TAS-20) was administered to assess the degree of alexithymia. The demographic data of mothers and children were also collected.
Results: The mean age of children with a disability was 5.6.+/- 3.1, and for healthy children was 6.3 +/- 3.7 (range 1-14) years. The mean age of mothers in the study group (n=86) was 33.9 +/- 6.1, and in the control group (n=32) was 35.2 +/- 7.3 years. Mothers of children with disabilities had a significantly higher degree of alexithymia (p=0.001) and a significantly higher mean score of HADS-anxiety (p=0.042) and HADS-depression (p=0.021). Alexithymia had a significant correlation with mother's depression (p=0.0001) and anxiety (p=0.0001). No significant correlations were found between alexithymia and child's age (p=0.303), duration of disability (p=0.0941), and mother's age (p=0.235).
Conclusion: Mothers caring for disabled children have higher features of alexithymia, and this is correlated to their elevated mood problems. Clinical implications are discussed. Saudi Med J 2012; Vol. 33(9): 995-1000
C1 [Al-Eithan, Muwafak H.] Sultan Bin Abdulaziz Humanitarian City, Med Affairs, Dept Psychol, Riyadh 11536, Saudi Arabia.
[Robert, Asirvatham A.] Sultan Bin Abdulaziz Humanitarian City, Med Affairs, Res Ctr, Riyadh 11536, Saudi Arabia.
[Al Juban, Hathab A.] Al Imam Muhammad Ibn Saud Islamic Univ, Dept Psychol, Riyadh 11536, Saudi Arabia.
RP Al-Eithan, MH (reprint author), Sultan Bin Abdulaziz Humanitarian City, Med Affairs, Dept Psychol, POB 64399, Riyadh 11536, Saudi Arabia.
EM al_eithan@yahoo.com
CR Al-Eithan MH, 2010, SAUDI MED J, V31, P1161
Baker BL, 2005, J INTELL DISABIL RES, V49, P575, DOI 10.1111/j.1365-2788.2005.00691.x
Barker ET, 2011, DEV PSYCHOL, V47, P551, DOI 10.1037/a0021268
BEBKO JM, 1987, J AUTISM DEV DISORD, V17, P565, DOI 10.1007/BF01486971
Bilgin S, 2009, J ADV NURS, V65, P2552, DOI 10.1111/j.1365-2648.2009.05163.x
Cohen IL, 2006, J AUTISM DEV DISORD, V36, P1077, DOI 10.1007/s10803-006-0145-7
Emerson E, 2008, AUST NZ J PUBL HEAL, V32, P53, DOI 10.1111/j.1753-6405.2008.00166.x
Espina A, 2003, J PSYCHOSOM RES, V55, P553, DOI 10.1016/S0022-3999(03)00016-3
Firat S, 2002, J KOREAN MED SCI, V17, P679
Hodapp RM, 1997, J AUTISM DEV DISORD, V27, P11, DOI 10.1023/A:1025865004299
Kojima M, 2007, J PSYCHOSOM RES, V63, P349, DOI 10.1016/j.jpsychores.2007.04.002
Loas G, 2001, J PSYCHOSOM RES, V50, P255, DOI 10.1016/S0022-3999(01)00197-0
Luminet O, 2001, PSYCHOTHER PSYCHOSOM, V70, P254, DOI 10.1159/000056263
Mazefsky CA, 2010, AUTISM RES, V3, P120, DOI 10.1002/aur.133
MOLSA PK, 1985, J MENT DEFIC RES, V29, P309
Mori K, 2009, PEDIATR INT, V51, P364, DOI 10.1111/j.1442-200X.2008.02728.x
Parker JDA, 2003, J PSYCHOSOM RES, V55, P269, DOI 10.1016/S0022-3999(02)00578-0
Picardi A, 2005, PSYCHOTHER PSYCHOSOM, V74, P371, DOI 10.1159/000087785
PIVEN J, 1991, J AM ACAD CHILD PSY, V30, P471, DOI 10.1097/00004583-199105000-00019
Seltzer MM, 2001, AM J MENT RETARD, V106, P265
Seltzer MM, 2004, AM J ORTHOPSYCHIAT, V74, P187, DOI 10.1037/0002-9432.74.2.187
Singer GHS, 2006, AM J MENT RETARD, V111, P155, DOI 10.1352/0895-8017(2006)111[155:MOCSOD]2.0.CO;2
Szatmari P, 2008, J AUTISM DEV DISORD, V38, P1859, DOI 10.1007/s10803-008-0576-4
Taylor GJ, 1996, J PSYCHOSOM RES, V41, P561, DOI 10.1016/S0022-3999(96)00224-3
Taylor GJ, 2000, CAN J PSYCHIAT, V45, P134
TOMKIEWICZ S, 1987, PEDIATRIE, V42, P375
Veisson M, 1999, SOC BEHAV PERSONAL, V27, P87, DOI 10.2224/sbp.1999.27.1.87
ZIGMOND AS, 1983, ACTA PSYCHIAT SCAND, V67, P361, DOI 10.1111/j.1600-0447.1983.tb09716.x
NR 28
TC 0
Z9 0
PU SAUDI MED J
PI RIYADH
PA ARMED FORCES HOSPITAL, PO BOX 7897,, RIYADH 11159, SAUDI ARABIA
SN 0379-5284
J9 SAUDI MED J
JI Saudi Med. J.
PD SEP
PY 2012
VL 33
IS 9
BP 995
EP 1000
PG 6
WC Medicine, General & Internal
SC General & Internal Medicine
GA 074ZF
UT WOS:000313852900010
PM 22964812
ER
PT J
AU Freckelton, I
AF Freckelton, Ian
TI Expert evidence by mental health professionals: The communication
challenge posed by evidence about Autism Spectrum Disorder, brain
injuries, and Huntington's Disease
SO INTERNATIONAL JOURNAL OF LAW AND PSYCHIATRY
LA English
DT Article
DE Expert evidence; Autism Spectrum Disorder; Huntington's Disease; Foetal
alcohol syndrome; Brain injury
ID FETAL-ALCOHOL-SYNDROME; UNITED-STATES; PREVALENCE; DEATH; FAS
AB By drawing upon mental health assessment issues about three non-mainstream conditions - Autism Spectrum Disorder, brain injuries, including Foetal Alcohol Syndrome, and Huntington's Disease - the author argues for the need for subtle, empathic and informed expert evidence about the potential nexus between such conditions and accused persons' criminal responsibility and culpability. He contends that what is forensically required is enhancement of the capacity of triers of fact to appreciate informedly and authentically, sometimes in a nuanced way, how persons with different, damaged or deteriorating brains experience situations and others' behaviour so that accused persons' conduct can fairly be evaluated without imposition of assumptions or expectations in respect of "normal persons" that may not be apposite. (C) 2012 Published by Elsevier Ltd.
C1 [Freckelton, Ian] Monash Univ, Clayton, Vic 3800, Australia.
RP Freckelton, I (reprint author), Barristers Clerk Howells, Owen Dixon Chambers W, 525 Lonsdale St, Melbourne, Vic 3000, Australia.
EM I.Freckelton@vicbar.com.au
CR ABEL EL, 1995, NEUROTOXICOL TERATOL, V17, P445, DOI 10.1016/0892-0362(95)98055-6
ABEL EL, 1991, ALCOHOL CLIN EXP RES, V15, P514, DOI 10.1111/j.1530-0277.1991.tb00553.x
ABEL EL, 1986, LANCET, V2, P1222
Appelbaum PS, 2001, PSYCHIATR SERV, V52, P885, DOI 10.1176/appi.ps.52.7.885
Australian law Reform Commission, 1985, EV INT REP
Australian Law Reform Commission, 1987, 38 ALRC
Babitsky S, 2005, BECOME DANGEROUS EXP
Barema Jean, 2005, TEST LIVING SHADOW H
Battaglia F. C., 1996, FOETAL ALCOHOL SYNDR
Blau T. H., 2001, PSYCHOL EXPERT WITNE
Brady M., 1991, HLTH YOUNG ABORIGINE
BRAY DL, 1989, CAN J PUBLIC HEALTH, V80, P42
Brodsky SL, 2004, COPING CROSS EXAMINA
Brodsky SL, 1991, TESTIFYING COURT GUI
Coady C. A. J., 1992, TESTIMONY
Ragnarsson KT, 1999, JAMA-J AM MED ASSOC, V282, P974
Deb S, 1999, AM J PSYCHIAT, V156, P374
Dwyer D, 2008, JUDICIAL ASSESSMENT OF EXPERT EVIDENCE, P1, DOI 10.1017/CBO9780511575136
Egeland GM, 1998, AM J PUBLIC HEALTH, V88, P781, DOI 10.2105/AJPH.88.5.781
Eggleston R., 1983, EVIDENCE PROOF PROBA
Farrer TJ, 2011, PROG NEURO-PSYCHOPH, V35, P390, DOI 10.1016/j.pnpbp.2011.01.007
Foster W, 1897, HARVARD LAW REV, V11, P169, DOI 10.2307/1321970
Freckelton I, 2012, PSYCHIAT PSYCHOL LAW, V19, P451
Freckelton I., 1987, TRIAL EXPERT
Freckelton Ian, 2010, J Law Med, V18, P7
Freckelton I., 2011, J LAW MED, P677
Freckelton I., FORENSIC IS IN PRESS
Freckelton I., J APPL RES IN PRESS
Freckelton I., 2007, PSYCHIAT PSYCHOL LAW, V14, P359, DOI 10.1375/pplt.14.2.359
Golan Tal, 2004, LAWS MEN LAWS NATURE
Gutheil T. G., 1998, PSYCHIAT COURT
Gutheil TG, 2009, PSYCHIAT EXPERT WITN
Gutheil TG, 1999, J AM ACAD PSYCHIATRY, V27, P546
Hammelmann H. A., 1947, MOD LAW REV, V10, P32, DOI 10.1111/j.1468-2230.1947.tb00035.x
HANSON JW, 1976, JAMA-J AM MED ASSOC, V235, P1458, DOI 10.1001/jama.235.14.1458
Harlow J., 1868, B MASSACHUSETTS MED, V2, P327
Harlow JM, 1868, BOSTON MED SURGICAL, V39, P389, DOI DOI 10.1056/NEJM184812130392001
Jackson M., 2009, ACQUIRED BRAIN INJUR
Jones C., 1994, EXPERT WITNESSES SCI
Kliegman RM, 2007, NELSON TXB PEDIAT
Lane AE, 2010, J AUTISM DEV DISORD, V40, P112, DOI 10.1007/s10803-009-0840-2
Law Commission (UK), 2011, 829 HC LAW COMM UK
Law Reform Commission of Ireland, 2008, EXPERT EVIDENCE
Lemoine P., 1968, OUEST MED, V25, P477
Leveson L.J., 2010, EXPERT EVIDENCE CRIM
LEWIS DO, 1986, AM J PSYCHIAT, V143, P838
LEWIS DO, 1988, AM J PSYCHIAT, V145, P584
LIST D., 2009, PSYCHIAT PSYCHOL LAW, V16, P16
Lord Justice Auld, 2001, REV CRIMINAL COURTS
Maas AIR, 2008, LANCET NEUROL, V7, P728, DOI 10.1016/S1474-4422(08)70164-9
May PA, 1991, ALCOHOL HEALTH RES W, V15, P239
McSherry B, COERCIVE CA IN PRESS
Melton G.B., 2007, PSYCHOL EVALUATIONS
Mnookin J, 2008, BROOKLYN LAW REV, P1009
New Zealand Law Commission, 1999, 55 NZLC
Cashin Andrew, 2009, J Forensic Nurs, V5, P70, DOI 10.1111/j.1939-3938.2009.01037.x
O'Leary CM, 2002, FETAL ALCOHOL SYNDRO
Poythress N, 1977, J PSYCHIAT LAW, P201
Quarrell O, 2008, HUNTINGTONS DIS
Rosenbaum R., 1941, PSYCHIAT QUART, V15, P93
Rushworth N., 2011, POLICY PAPER OUT SIG
Selby H., EXPERT EVID IN PRESS
Shiroma Eric J, 2010, J Correct Health Care, V16, P147, DOI 10.1177/1078345809356538
Slovenko R, 2009, PSYCHIATRY IN LAW - LAW IN PSYCHIATRY, SECOND EDITION, P1
University of Adelaide, 2009, PREV INF DEATHS AB T
Walvisch J, 2010, PSYCHIAT PSYCHOL LAW, V17, P187, DOI 10.1080/13218710903433949
Wexler Alice, 1995, MAPPING FATE MEMOIR
Williams RJ, 1999, J STUD ALCOHOL, V60, P833
WINSLADE WILLIAM J., 1998, CONFRONTING TRAUMATI
Ziskin J, 1995, COPING PSYCHIAT PSYC
NR 70
TC 1
Z9 1
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0160-2527
J9 INT J LAW PSYCHIAT
JI Int. J. Law Psychiatr.
PD SEP-DEC
PY 2012
VL 35
IS 5-6
SI SI
BP 372
EP 379
DI 10.1016/j.ijlp.2012.09.008
PG 8
WC Law; Psychiatry
SC Government & Law; Psychiatry
GA 067SR
UT WOS:000313315900005
PM 23151404
ER
PT J
AU Chojnicka, I
Ploski, R
AF Chojnicka, Izabela
Ploski, Rafal
TI Polish version of the ADOS (Autism Diagnostic Observation
Schedule-Generic)
SO PSYCHIATRIA POLSKA
LA Polish
DT Article
DE autistic disorder/diagnosis; observation; psychometrics/statistics;
numerical data
AB The article presents the Polish version of the Autism Diagnostic Observation Schedule-Generic (ADOS), which together with the Autism Diagnostic Interview - Revised (ADI-R) is cited as the "gold standard" for the diagnosis of autism. The ADOS is a standardised, semi-structured observation protocol appropriate for children and adults of differing age and language levels. It is linked to ICD-10 and DSM-IV-TR criteria. The ADOS consists of four modules, ranging from Module 1 for nonverbal individuals to Module 4 for verbally fluent adults.
The adequate inter-rater reliability for items has been established. The protocol has high discriminant validity and distinguishes children with pervasive developmental disorders from children, who are outside of the spectrum. Although it does not enable to distinguish individuals with pervasive developmental disorder, unspecified from individuals with childhood autism.
The paper presents subsequent steps of the translation process of the original version into Polish, as well as a chosen adaptation strategy of the Polish version.
The ADOS is a very useful tool both for clinical diagnosis and for the scientific purpose diagnosis. In this last case it is extremely important to use a standardised method. Until now, there was no standardised diagnostic tool for autism in Poland.
C1 [Chojnicka, Izabela; Ploski, Rafal] Zaklad Genetyki Med WUM, PL-02106 Warsaw, Poland.
RP Chojnicka, I (reprint author), Zaklad Genetyki Med WUM, Ul Pawinskiego 3C, PL-02106 Warsaw, Poland.
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
Brzezinski J., 1999, METODOLOGIA BADAN PS
DILAVORE PC, 1995, J AUTISM DEV DISORD, V25, P355, DOI 10.1007/BF02179373
DRWAL R.A., 1995, ADAPTACJA KWESTIONAR
LORD C, 1989, J AUTISM DEV DISORD, V19, P185, DOI 10.1007/BF02211841
LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
Pisula E., 2010, AUTYZM PRZYCZYNY SYM
Pisula E., 2005, MALE DZIECKO AUTYZME
Volkmar F. R., 2005, HDB AUTISM PERVASIVE
World Health Organization, 1992, INT CLASS DIS DIAGN
NR 11
TC 1
Z9 1
PU WYDAWNICZY POLSKIEGO TOWARZYSTWA
PI CRACOW
PA LENARTOWICZA 14 STRREET,, CRACOW, 31-138, POLAND
SN 0033-2674
J9 PSYCHIATR POL
JI Psychiatr. Pol.
PD SEP-OCT
PY 2012
VL 46
IS 5
BP 781
EP 789
PG 9
WC Psychiatry
SC Psychiatry
GA 067QL
UT WOS:000313310100005
PM 23394018
ER
PT J
AU Schertz, HH
Reichow, B
Tan, P
Vaiouli, P
Yildirim, E
AF Schertz, Hannah H.
Reichow, Brian
Tan, Paulo
Vaiouli, Potheini
Yildirim, Emine
TI Interventions for Toddlers With Autism Spectrum Disorders: An Evaluation
of Research Evidence
SO JOURNAL OF EARLY INTERVENTION
LA English
DT Article
DE autism spectrum disorders; disabilities and development delays; Part C
services; components of practice; infants and toddlers; young children;
instruction
ID PERVASIVE DEVELOPMENTAL DISORDERS; RANDOMIZED CONTROLLED-TRIAL; JOINT
ATTENTION; YOUNG-CHILDREN; SPECIAL-EDUCATION; LANGUAGE-DEVELOPMENT;
SCHOOL-PSYCHOLOGY; RESEARCH DESIGN; SKILLS; COMMUNICATION
AB Recently emerging intervention studies for toddlers with autism spectrum disorders (ASD) were reviewed through a systematic assessment of intervention outcomes, research rigor, and intervention features. The review includes published peer-reviewed experimental studies of toddlers with high risk for or diagnosis of ASD in which the majority of interventions occurred before age 36 months. Of 20 identified research studies, 6 were group comparison studies, all of which showed small to large magnitudes of effect when a uniform metric was applied. Fourteen were single-case design (SCD) studies, all of which reported effects on a variety of outcomes. When grouped by area of intervention focus (communication, general development, family well-being, imitation, joint attention, and play), commonly identified needs within focus areas were for replication, common measures, and authentic practices. A majority of studies in most focus areas showed strong to acceptable levels of research rigor, though this is an area of ongoing need.
C1 [Schertz, Hannah H.] Indiana Univ, Sch Educ, Dept Curriculum & Instruct, Bloomington, IN 47405 USA.
[Reichow, Brian] Yale Univ, Ctr Child Study, New Haven, CT 06520 USA.
RP Schertz, HH (reprint author), Indiana Univ, Sch Educ, Dept Curriculum & Instruct, 201 N Rose Ave, Bloomington, IN 47405 USA.
EM hschertz@indiana.edu
CR Adamson LB, 2001, J APPL DEV PSYCHOL, V22, P439, DOI 10.1016/S0193-3973(01)00089-2
American Psychiatric Association, 2000, DIAGN STAT MAN MENT
Autism Speaks, 2011, AUT SPEAKS TODDL TRE
Bates E., 1979, PAPERS REPORTS CHILD, V17, P106
Brookman-Frazee L, 2009, APPLIED BEHAVIOR ANALYSIS FOR CHILDREN WITH AUTISM SPECTRUM DISORDERS, P237, DOI 10.1007/978-1-4419-0088-3_14
Brookman-Frazee L, 2004, J POSIT BEHAV INTERV, V6, P195, DOI 10.1177/10983007040060040201
Cardon TA, 2011, J AUTISM DEV DISORD, V41, P654, DOI 10.1007/s10803-010-1086-8
Carter AS, 2011, J CHILD PSYCHOL PSYC, V52, P741, DOI 10.1111/j.1469-7610.2011.02395.x
Cicchetti DV, 2011, EVIDENCE-BASED PRACTICES AND TREATMENTS FOR CHILDREN WITH AUTISM, P41, DOI 10.1007/978-1-4419-6975-0_3
Coakley T, 2010, INFANT YOUNG CHILD, V23, P145, DOI 10.1097/IYC.0b013e3181d5c3b9
Cohen J., 1988, STAT POWER ANAL BEHA, V2nd
Cooper H, 2010, RES SYNTHESIS METAAN, V4th
Copple C., 2009, DEV APPROPRIATE PRAC, V3rd
Dawson G, 2010, PEDIATRICS, V125, pE17, DOI 10.1542/peds.2009-0958
Dempsey I, 2008, TOP EARLY CHILD SPEC, V28, P42, DOI 10.1177/0271121408316699
Drew A, 2002, EUR CHILD ADOLES PSY, V11, P266, DOI 10.1007/s00787-002-0299-6
Dunst C. J., 2006, J POLICY PRACT INTEL, V3, P3, DOI [10.1111/j.1741-1130.2006.00047.x, DOI 10.1111/J.1741-1130.2006.00047.X]
Dunst CJ, 2007, MENT RETARD DEV D R, V13, P370, DOI 10.1002/mrdd.20176
Eikeseth S, 2009, RES DEV DISABIL, V30, P158, DOI 10.1016/j.ridd.2008.02.003
Eldevik S, 2009, J CLIN CHILD ADOLESC, V38, P439, DOI 10.1080/15374410902851739
Esch BE, 2009, J APPL BEHAV ANAL, V42, P225, DOI 10.1901/jaba.2009.42-225
TOMASELLO M, 1986, CHILD DEV, V57, P1454, DOI 10.1111/j.1467-8624.1986.tb00470.x
Feldman R, 1999, DEV PSYCHOL, V35, P223, DOI 10.1037/0012-1649.35.1.223
Gersten R, 2005, EXCEPT CHILDREN, V71, P149
Guralnick MJ, 1998, AM J MENT RETARD, V102, P319
Hattie JAC, 2009, VISIBLE LEARNING: A SYNTHESIS OF OVER 800 META-ANALYSES RELATING TO ACHIEVEMENT, P1
Hebbeler KM, 2002, EARLY CHILD RES Q, V17, P28, DOI 10.1016/S0885-2006(02)00128-X
Hedges L., 1985, STAT MODELS METAANAL
Higgins JPT, 2008, COCHRANE HDB SYSTEMA
Hine JF, 2006, TOP EARLY CHILD SPEC, V26, P83, DOI 10.1177/02711214060260020301
Horner RH, 2005, EXCEPT CHILDREN, V71, P165
Howlin P, 2009, AJIDD-AM J INTELLECT, V114, P23, DOI 10.1352/2009.114:23;nd41
Ingersoll B, 2007, RES DEV DISABIL, V28, P163, DOI 10.1016/j.ridd.2006.02.004
Ingersoll B., 2005, FOCUS AUTISM OTHER D, V20, P213, DOI DOI 10.1177/10883576050200040301
Interagency Autism Coordinating Committee, 2005, 2005 IACC AUT SPECTR
Jadad AR, 1996, CONTROL CLIN TRIALS, V1, P1, DOI DOI 10.1016/0197-2456(95)00134-4]
Johnson CP, 2007, PEDIATRICS, V120, P1183, DOI 10.1542/peds.2007-2361
Jones EA, 2006, BEHAV MODIF, V30, P782, DOI 10.1177/0145445506289392
Juni P, 1999, JAMA-J AM MED ASSOC, V282, P1054, DOI 10.1001/jama.282.11.1054
Landa RJ, 2011, J CHILD PSYCHOL PSYC, V52, P13, DOI 10.1111/j.1469-7610.2010.02288.x
Landry SH, 2006, DEV PSYCHOL, V42, P627, DOI 10.1037/0012-1649.42.4.627
Leew SV, 2010, CAN J OCCUP THER, V77, P113, DOI 10.2182/cjot.2010.77.2.7
Lewis-Snyder G, 2002, SCHOOL PSYCHOL QUART, V17, P423, DOI 10.1521/scpq.17.4.423.20868
Lipsey M. W., 2001, PRACTICAL METAANALYS
Lord C., 1999, AUTISM DIAGNOSTIC OB
Lord C, 2006, ARCH GEN PSYCHIAT, V63, P694, DOI 10.1001/archpsyc.63.6.694
LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
Luyster R, 2009, J AUTISM DEV DISORD, V39, P1305, DOI 10.1007/s10803-009-0746-z
Mahoney G, 2007, INFANT YOUNG CHILD, V20, P311
Mahoney G, 1998, TOP EARLY CHILD SPEC, V18, P5
McArthur D, 1996, J AUTISM DEV DISORD, V26, P481, DOI 10.1007/BF02172271
McConachie H, 2007, J EVAL CLIN PRACT, V13, P120, DOI 10.1111/j.1365-2753.2006.00674.x
McLean M. E., 2005, DEC RECOMMENDED PRAC
Moher D, 1998, LANCET, V352, P609, DOI 10.1016/S0140-6736(98)01085-X
Mullen E, 1995, MULLEN SCALES EARLY
MUNDY P, 1990, J AUTISM DEV DISORD, V20, P115, DOI 10.1007/BF02206861
Mundy P, 2000, COMM LANG INTERVEN, V9, P55
National Research Council, 2001, ED CHILDR AUT
Odom SL, 2005, EXCEPT CHILDREN, V71, P137
Odom SL, 2003, J SPEC EDUC, V37, P164, DOI 10.1177/00224669030370030601
Paparella T, 2004, INFANT YOUNG CHILD, V17, P269
Park JH, 2011, TOP EARLY CHILD SPEC, V31, P37, DOI 10.1177/0271121410393750
Petticrew M, 2006, SYSTEMATIC REVIEWS IN THE SOCIAL SCIENCES: A PRACTICAL GUIDE, P1, DOI 10.1002/9780470754887
Polanin J. R., 2012, CAMPB C COP DENM
Reichow B, 2011, EVIDENCE-BASED PRACTICES AND TREATMENTS FOR CHILDREN WITH AUTISM, P25, DOI 10.1007/978-1-4419-6975-0_2
Reichow B, 2012, J AUTISM DEV DISORD, V42, P512, DOI 10.1007/s10803-011-1218-9
Reichow B, 2010, J AUTISM DEV DISORD, V40, P149, DOI 10.1007/s10803-009-0842-0
Reichow B, 2008, J AUTISM DEV DISORD, V38, P1311, DOI 10.1007/s10803-007-0517-7
Reichow B, 2011, EVIDENCE-BASED PRACTICES AND TREATMENTS FOR CHILDREN WITH AUTISM, P3, DOI 10.1007/978-1-4419-6975-0_1
Reichow B, 2009, J AUTISM DEV DISORD, V39, P23, DOI 10.1007/s10803-008-0596-0
Reichow B., 2007, INT M AUT RES SEATTL
Robins DL, 2001, J AUTISM DEV DISORD, V31, P131, DOI 10.1023/A:1010738829569
Rocha ML, 2007, J EARLY INTERVENTION, V29, P154, DOI 10.1177/105381510702900207
Rogers SJ, 2008, J CLIN CHILD ADOLESC, V37, P8, DOI 10.1080/15374410701817808
Rothstein HR, 2005, PUBLICATION BIAS IN META-ANALYSIS: PREVENTION, ASSESSMENT AND ADJUSTMENTS, P1
Schertz HH, 2011, TOP EARLY CHILD SPEC, V31, P4, DOI 10.1177/0271121410382460
Schertz HH, 2007, J AUTISM DEV DISORD, V37, P1562, DOI 10.1007/s10803-006-0290-z
Schopler E., 1988, CHILDHOOD AUTISM RAT
Shernoff ES, 2002, SCHOOL PSYCHOL QUART, V17, P390, DOI 10.1521/scpq.17.4.390.20863
Siegel M, 2012, J AUTISM DEV DISORD, V42, P1592, DOI 10.1007/s10803-011-1399-2
Sigman M, 1999, MONOGR SOC RES CHILD, V64, P1, DOI 10.1111/1540-5834.00002
Siller M, 2008, DEV PSYCHOL, V44, P1691, DOI 10.1037/a0013771
Silverman WK, 2008, J CLIN CHILD ADOLESC, V37, P1, DOI 10.1080/15374410701817725
Slavin R. E., 1986, EDUC RES, V15, P5, DOI 10.3102/0013189X015009005
Snyder P., 2006, EVIDENCE BASED PRACT, P35
Sparrow S, 1984, VINELAND ADAPTIVE BE
Sparrow SS, 2005, VINELAND ADAPTIVE BE
Spector JE, 2011, J AUTISM DEV DISORD, V41, P1411, DOI 10.1007/s10803-010-1165-x
Straus SE, 2005, EVIDENCE BASED MED P
Tager-Flusberg H, 2009, J SPEECH LANG HEAR R, V52, P643, DOI 10.1044/1092-4388(2009/08-0136)
Trivette CM, 2010, TOP EARLY CHILD SPEC, V30, P3, DOI 10.1177/0271121410364250
Tronick E., 2007, NEUROBEHAVIORAL SOCI
VanDerHeyden A. M., 2002, BEHAV ANAL TODAY, V3, P188
Virues-Ortega J, 2010, CLIN PSYCHOL REV, V30, P387, DOI 10.1016/j.cpr.2010.01.008
Vismara LA, 2007, J POSIT BEHAV INTERV, V9, P214, DOI 10.1177/10983007070090040401
Vismara LA, 2008, J EARLY INTERVENTION, V31, P91, DOI 10.1177/1053815108325578
Wetherby AM, 2006, TOP EARLY CHILD SPEC, V26, P67, DOI 10.1177/02711214060260020201
Zachor A. D., 2007, RES AUTISM SPECT DIS, V1, P304
Zwaigenbaum L, 2007, J AUTISM DEV DISORD, V37, P466, DOI 10.1007/s10803-006-0179-x
NR 99
TC 4
Z9 4
PU COUNCIL EXCEPTIONAL CHILDREN
PI ARLINGTON
PA 1110 N GLEBE RD, ARLINGTON, VA 22201-5704 USA
SN 1053-8151
EI 2154-3992
J9 J EARLY INTERVENTION
JI J. Early Interv.
PD SEP
PY 2012
VL 34
IS 3
BP 166
EP 189
DI 10.1177/1053815112470721
PG 24
WC Education, Special; Psychology, Educational; Rehabilitation
SC Education & Educational Research; Psychology; Rehabilitation
GA 060KW
UT WOS:000312777700003
ER
PT J
AU Acar, C
Diken, IH
AF Acar, Cimen
Diken, Ibrahim H.
TI Reviewing Instructional Studies Conducted Using Video Modeling to
Children with Autism
SO KURAM VE UYGULAMADA EGITIM BILIMLERI
LA English
DT Review
DE Autistic Disorder (Autism); Video Modeling; Review; Research
ID TEACH PERSPECTIVE-TAKING; OF-THE-LITERATURE; SPECTRUM DISORDERS;
COMMUNICATION-SKILLS; YOUNG-CHILDREN; SOCIAL-SKILLS; PRETEND PLAY;
IN-VIVO; SELF; REINFORCEMENT
AB This study explored 31 instructional research articles written using video modeling to children with autism and published in peer-reviewed journals. The studies in this research have been reached by searching EBSCO, Academic Search Complete, ERIC and other Anadolu University online search engines and using keywords such as "autism, video modeling, autism spectrum disorders with video modeling and video modeling interventions". It is observed that most of studies have been carried out with children with autism aged between 3 and 11. The studies have been categorized based on their scopes: studies conducted using only video modeling, video modeling studies in which subjects of studies are models, studies in which video modeling and additional practices are used together and studies in which video modeling is compared with other practices. It is observed also that results of studies have indicated that video modeling is effective on teaching social skills, play skills, language and communication skills, functional skills, self-care skills, and daily life skills to children with autism.
C1 [Diken, Ibrahim H.] Anadolu Univ, Dept Special Educ, Eskisehir, Turkey.
RP Diken, IH (reprint author), Eskisehir Anadolu Univ, Egitim Fak, Ozel Egitim Bolumu, Yunus Emre Kampusu, TR-26470 Eskisehir, Turkey.
EM ihdiken@anadolu.edu.tr
CR Ayres KM, 2005, EDUC TRAIN DEV DISAB, V40, P183
Bellini S, 2007, SCHOOL PSYCHOL REV, V36, P80
Bellini S, 2007, EXCEPT CHILDREN, V73, P264
Buggey T., 2005, FOCUS AUTISM OTHER D, V20, P52, DOI DOI 10.1177/10883576050200010501
Charlop M. H., 2010, ED TREATMENT CHILDRE, V33, P371, DOI DOI 10.1353/ETC.0.0104
Charlop-Christy MH, 2000, J AUTISM DEV DISORD, V30, P537, DOI 10.1023/A:1005635326276
Charlop-Christy MH, 2003, J POSIT BEHAV INTERV, V5, P12, DOI 10.1177/10983007030050010101
Corbett B., 2003, BEHAV ANAL TODAY, V4, P367
Corbett B. A., 2005, J EARLY INTENSIVE BE, V2, P2
D'Ateno P, 2003, J POSIT BEHAV INTERV, V5, P5, DOI 10.1177/10983007030050010801
Dauphin M, 2004, J POSIT BEHAV INTERV, V6, P238, DOI 10.1177/10983007040060040501
Delano ME, 2007, REM SPEC EDUC, V28, P33, DOI 10.1177/07419325070280010401
Diken I. H., 2010, TURK ERK MUD YAKL SE
Gena A, 2005, J AUTISM DEV DISORD, V35, P545, DOI 10.1007/s10803-005-0014-9
Graetz J. E., 2006, TEACHING EXCEPTIONAL, V38, P43
Gul SO, 2010, KURAM UYGULAMA EGI, V10, P249
Hermansen E, 2007, ED TREATMENT CHILDRE, V30, P183, DOI DOI 10.1353/ETC.2007.0029
Karasu N., 2009, TURK EGITIM BILIMLER, V7, P143
Keen D, 2007, J DEV PHYS DISABIL, V19, P291, DOI 10.1007/s10882-007-9044-x
Keenan M., 2004, EUROPEAN J BEHAV ANA, V5, P1
Kircaali-Iftar G., 2007, OTIZM SPEKTRUM BOZUK
Koroglu E., 2001, PSIK HAST TAN SIN KI
Kroeger KA, 2007, J AUTISM DEV DISORD, V37, P808, DOI 10.1007/s10803-006-0207-x
LeBlanc LA, 2003, J APPL BEHAV ANAL, V36, P253, DOI 10.1901/jaba.2003.36-253
Litras S., 2010, AUTISM RES TREATMENT, V2010, P1
MacDonald R, 2005, BEHAV INTERVENT, V20, P225, DOI 10.1002/bin.197
MacDonald R, 2009, J APPL BEHAV ANAL, V42, P43, DOI 10.1901/jaba.2009.42-43
Maione L, 2006, J POSIT BEHAV INTERV, V8, P106, DOI 10.1177/10983007060080020201
Marcus A, 2009, J APPL BEHAV ANAL, V42, P335, DOI 10.1901/jaba.2009.42-335
Murzynski NT, 2007, BEHAV INTERVENT, V22, P147, DOI 10.1002/bin.224
National Autism Center (NAC), 2009, NAT STAND REP
Nikopolou-Smyrni P., 2008, J EARLY INTENSIVE BE, V5, P30
Nikopoulos CK, 2007, J AUTISM DEV DISORD, V37, P678, DOI 10.1007/s10803-006-0195-x
Nikopoulos CK, 2003, BEHAV INTERVENT, V18, P87, DOI 10.1002/bin.129
Nikopoulos CK, 2004, J APPL BEHAV ANAL, V37, P93, DOI 10.1901/jaba.2004.37-93
Palechka G., 2010, EDUC TREAT CHILD, V33, P457, DOI DOI 10.1353/ETC.0.0100
Paterson CR, 2007, BEHAV MODIF, V31, P660, DOI 10.1177/0145445507301651
Reagon K. A., 2006, EDUC TREAT CHILD, V29, P517
Reeve S. A., 2010, EDUC TREAT CHILD, V33, P351, DOI DOI 10.1353/ETC.0.0103
Sancho K., 2010, EDUC TREAT CHILD, V33, P421, DOI DOI 10.1353/ETC.0.0097
Sansosti FJ, 2008, J POSIT BEHAV INTERV, V10, P162, DOI 10.1177/1098300708316259
Sherer M, 2001, BEHAV MODIF, V25, P140, DOI 10.1177/0145445501251008
Shipley-Benamou R., 2002, J POSIT BEHAV INTERV, V4, P163
Shukla-Mehta S, 2010, FOCUS AUTISM DEV DIS, V25, P23, DOI 10.1177/1088357609352901
Tereshko L., 2009, RES AUTISM SPECT DIS, V4, P479
Wert BY, 2003, J POSIT BEHAV INTERV, V5, P30, DOI 10.1177/10983007030050010501
NR 46
TC 0
Z9 0
PU EDAM
PI ISTANBUL
PA KISIKLI MH ALEMDAG CD YAN YOL SK, SBK IS MERKEZI NO 5, KAT 1 USKUDAR,
ISTANBUL, 81190, TURKEY
SN 1303-0485
J9 KURAM UYGUL EGIT BIL
JI Kuram Uygulamada Egit. Bilim.
PD FAL
PY 2012
VL 12
IS 4
BP 2731
EP 2735
PG 5
WC Education & Educational Research
SC Education & Educational Research
GA 035OC
UT WOS:000310955500022
ER
PT J
AU Ergenekon, Y
AF Ergenekon, Yasemin
TI Teaching Basic First-Aid Skills against Home Accidents to Children with
Autism through Video Modeling
SO KURAM VE UYGULAMADA EGITIM BILIMLERI
LA English
DT Article
DE Basic First-Aid Skills; Safety Skills; Home Accidents; Video Modeling;
Children with Autism
ID MODERATE INTELLECTUAL DISABILITIES; SEVERE MENTAL-RETARDATION;
YOUNG-CHILDREN; 1ST AID; STUDENTS; PROGRAM; SAFETY; INSTRUCTION; ADULTS;
INDIVIDUALS
AB It is known that children with DD can learn first-aid skills and use whenever needed. Applying first-aid skills was taught to three inclusion students with autism through "first-aid skills training package". In the study multiple probe design with probe trials across behaviors was used. The findings indicated that first-aid skills training package was effective and the subjects maintained and generalized their acquired skills to the cuts, abrasions, and minor burns on their own or researcher's different parts of body and to different materials. Social validity data that was collected through social comparison revealed that the subjects could not accomplish these target behaviors before the intervention but their peers with normal development could accomplish these skills at 78% level.
C1 Anadolu Univ, Res Inst Handicapped, TR-26470 Eskisehir, Turkey.
RP Ergenekon, Y (reprint author), Anadolu Univ, Res Inst Handicapped, TR-26470 Eskisehir, Turkey.
EM yergenek@anadolu.edu.tr
CR Akmanoglu N, 2011, AUTISM, V15, P205, DOI 10.1177/1362361309352180
Bidwell MA, 2004, BEHAV INTERVENT, V19, P263, DOI 10.1002/bin.165
Bingol N., 2005, GUVENLI DAVRANIS ILK
Carruth AK, 2010, J SCHOOL HEALTH, V80, P453, DOI 10.1111/j.1746-1561.2010.00527.x
Charlop-Christy MH, 2000, J AUTISM DEV DISORD, V30, P537, DOI 10.1023/A:1005635326276
Christensen A. M., 1996, ED TREATMENT CHILDRE, V17, P3
Christensen A. M., 1993, J BEHAV ED, V3, P109, DOI 10.1007/BF00947031
COLLINS BC, 1991, EDUC TRAIN MENT RET, V26, P305
D'Ateno P, 2003, J POSIT BEHAV INTERV, V5, P5, DOI 10.1177/10983007030050010801
Dawson G, 2000, J APPL DEV PSYCHOL, V21, P299, DOI 10.1016/S0193-3973(99)00042-8
Degirmenci H. D, 2010, THESIS ANADOLU U ESK
Delano ME, 2007, REM SPEC EDUC, V28, P33, DOI 10.1177/07419325070280010401
Gast D. L., 1992, ED TREATMENT CHILDRE, V15, P101
Bevill AR, 1998, TOP EARLY CHILD SPEC, V18, P222
Haliskucuk E. S, 2007, THESIS ABANT IZZET B
Hermansen E, 2007, ED TREATMENT CHILDRE, V30, P183, DOI DOI 10.1353/ETC.2007.0029
Hoch Hannah, 2009, Behav Anal Pract, V2, P14
Kennedy C, 2005, SINGLE CASE DESIGNS
MARCHANDMARTELLA NE, 1992, J APPL BEHAV ANAL, V25, P841, DOI 10.1901/jaba.1992.25-841
Marchand-Martella N. E., 1990, BEHAV RESIDENTIAL TR, V53.0.CO;2-J
Eapen V, 2009, J PSYCHOSOM RES, V67, P525, DOI 10.1016/j.jpsychores.2009.08.003
EAPEN V, 1993, BRIT J PSYCHIAT, V162, P593, DOI 10.1192/bjp.162.5.593
Ercan-Sencicek AG, 2010, NEW ENGL J MED, V362, P1901, DOI 10.1056/NEJMoa0907006
Francks C, 2007, MOL PSYCHIATR, V12, P1129, DOI 10.1038/sj.mp.4002053
Freeman RD, 2000, DEV MED CHILD NEUROL, V42, P436, DOI 10.1017/S0012162200000839
Gauthier J, 2011, HUM GENET, V130, P563, DOI 10.1007/s00439-011-0975-z
George SK, 2011, AGING CELL, V10, P584, DOI 10.1111/j.1474-9726.2011.00686.x
Grabrucker AM, 2011, EMBO J, V30, P569, DOI 10.1038/emboj.2010.336
Haas HL, 2008, PHYSIOL REV, V88, P1183, DOI 10.1152/physrev.00043.2007
Habib AA, 1998, ONCOGENE, V16, P1525, DOI 10.1038/sj.onc.1201683
Hanna PA, 1999, NEUROLOGY, V53, P813
Herbert MR, 2010, CURR OPIN NEUROL, V23, P103, DOI 10.1097/WCO.0b013e328336a01f
Hirai H, 2005, NAT NEUROSCI, V8, P1534, DOI 10.1038/nn1576
Howard MA, 2010, P NATL ACAD SCI USA, V107, P3805, DOI 10.1073/pnas.0914422107
Joo JY, 2011, BIOCHEM BIOPH RES CO, V406, P627, DOI 10.1016/j.bbrc.2011.02.108
Kadesjo B, 2000, J AM ACAD CHILD PSY, V39, P548, DOI 10.1097/00004583-200005000-00007
Kalanithi PSA, 2005, P NATL ACAD SCI USA, V102, P13307, DOI 10.1073/pnas.0502624102
Kano M, 1997, NEURON, V18, P71, DOI 10.1016/S0896-6273(01)80047-7
Kask M, 2011, BIOCHEM BIOPH RES CO, V411, P56, DOI 10.1016/j.bbrc.2011.06.085
Kataoka Y, 2010, J COMP NEUROL, V518, P277, DOI 10.1002/cne.22206
Keen-Kim D, 2006, HUM MOL GENET, V15, P3324, DOI 10.1093/hmg/ddl408
Knight S, 2010, AM J MED GENET B, V153B, P656, DOI 10.1002/ajmg.b.31035
Ko J, 2011, J CELL BIOL, V194, P323, DOI 10.1083/jcb.201101072
Ko J, 2009, NEURON, V64, P791, DOI 10.1016/j.neuron.2009.12.012
Kroisel PM, 2001, AM J MED GENET, V101, P259, DOI 10.1002/1096-8628(20010701)101:3<259::AID-AJMG1374>3.0.CO;2-#
Lauren J, 2003, GENOMICS, V81, P411, DOI 10.1016/S0888-7543(03)00030-2
Laurin N, 2009, AM J MED GENET B, V150B, P95, DOI 10.1002/ajmg.b.30779
Lawson-Yuen A, 2008, EUR J HUM GENET, V16, P614, DOI 10.1038/sj.ejhg.5202006
Lee SJ, 2012, J NEUROSCI, V32, P4688, DOI 10.1523/JNEUROSCI.5584-11.2012
Linhoff MW, 2009, NEURON, V61, P734, DOI 10.1016/j.neuron.2009.01.017
Lu B, 2008, BIOL REPROD, V78, P601, DOI 10.1095/biolreprod.107.065987
Lu CS, 2008, NEUROGENETICS, V9, P271, DOI 10.1007/s10048-008-0140-6
Maestrini E, 2010, MOL PSYCHIATR, V15, P954, DOI 10.1038/mp.2009.34
Matsuda K, 2011, EUR J NEUROSCI, V33, P1447, DOI 10.1111/j.1460-9568.2011.07638.x
Matsumoto N, 2000, EUR J HUM GENET, V8, P875, DOI 10.1038/sj.ejhg.5200549
Merette C, 2000, AM J HUM GENET, V67, P1008, DOI 10.1086/303093
Miranda DM, 2009, AM J MED GENET B, V150B, P483, DOI 10.1002/ajmg.b.30840
Missler M, 2003, NATURE, V423, P939, DOI 10.1038/nature01755
Missler M, 1998, J BIOL CHEM, V273, P34716, DOI 10.1074/jbc.273.52.34716
Miura E, 2006, EUR J NEUROSCI, V24, P750, DOI 10.1111/j.1460-9568.2006.04950.x
Mondin M, 2011, J NEUROSCI, V31, P13500, DOI 10.1523/JNEUROSCI.6439-10.2011
O'Rourke JA, 2009, J PSYCHOSOM RES, V67, P533, DOI 10.1016/j.jpsychores.2009.06.006
Oudejans CBM, 2004, MOL HUM REPROD, V10, P589, DOI 10.1093/molehr/gah080
Pagnamenta AT, 2010, BIOL PSYCHIAT, V68, P320, DOI 10.1016/j.biopsych.2010.02.002
Paschou P, 2004, AM J HUM GENET, V75, P545, DOI 10.1086/424389
Patel C, 2011, EUR J HUM GENET, V19, P634, DOI 10.1038/ejhg.2010.238
PAULS DL, 1986, NEW ENGL J MED, V315, P993, DOI 10.1056/NEJM198610163151604
Penagarikano O, 2011, CELL, V147, P235, DOI 10.1016/j.cell.2011.08.040
Perche O, 2010, PATHOL BIOL, V58, P381, DOI 10.1016/j.patbio.2009.12.005
Petek E, 2001, AM J HUM GENET, V68, P848, DOI 10.1086/319523
Petek E, 2007, MOL GENET GENOMICS, V277, P71, DOI 10.1007/s00438-006-0173-1
Pouille F, 2009, NAT NEUROSCI, V12, P1577, DOI 10.1038/nn.2441
Proenca CC, 2011, TRENDS NEUROSCI, V34, P143, DOI 10.1016/j.tins.2011.01.001
Robertson MM, 2009, J PSYCHOSOM RES, V67, P475, DOI 10.1016/j.jpsychores.2009.07.010
Robertson MM, 2006, J PSYCHOSOM RES, V61, P365, DOI 10.1016/j.jpsychores.2006.06.011
Rong YQ, 2012, J NEUROCHEM, V120, P528, DOI 10.1111/j.1471-4159.2011.07604.x
Rubenstein JLR, 2010, CURR OPIN NEUROL, V23, P118, DOI 10.1097/WCO.0b013e328336eb13
Rumbaugh G, 2003, J NEUROSCI, V23, P4567
Shelley BP, 2007, J INTELL DISABIL RES, V51, P620, DOI 10.1111/j.1365-2788.2006.00943.x
Siddiqui TJ, 2011, CURR OPIN NEUROBIOL, V21, P132, DOI 10.1016/j.conb.2010.08.016
Simonic I, 2001, AM J MED GENET, V105, P163, DOI 10.1002/ajmg.1192
Singh D N, 1982, J Natl Med Assoc, V74, P675
Solda G, 2008, BMC GENOMICS, V9, DOI 10.1186/1471-2164-9-174
Sousa I, 2010, MOL AUTISM, V1, DOI 10.1186/2040-2392-1-7
State MW, 2003, P NATL ACAD SCI USA, V100, P4684, DOI 10.1073/pnas.0730775100
State MW, 2011, CURR OPIN GENET DEV, V21, P302, DOI 10.1016/j.gde.2011.01.007
State MW, 2010, NEURON, V68, P254, DOI 10.1016/j.neuron.2010.10.004
Sugita S, 2001, J CELL BIOL, V154, P435, DOI 10.1083/jcb.200105003
Sundaram SK, 2010, NEUROLOGY, V74, P1583, DOI 10.1212/WNL.0b013e3181e0f147
SVERD J, 1991, AM J MED GENET, V39, P173, DOI 10.1002/ajmg.1320390212
Tassabehji M, 2008, HUM MUTAT, V29, P1017, DOI 10.1002/humu.20741
TAYLOR LD, 1991, NEUROLOGY, V41, P1513
Paula D, 1999, AM J HUM GENET, V65, P1428
Cath D, 2007, AM J HUM GENET, V80, P265
Tossell K, 2011, DEV BIOL, V352, P341, DOI 10.1016/j.ydbio.2011.02.002
Turrigiano G, 2012, CSH PERSPECT BIOL, V4, DOI 10.1101/cshperspect.a005736
Uemura T, 2010, CELL, V141, P1068, DOI 10.1016/j.cell.2010.04.035
Uezato A, 2012, BEHAV BRAIN FUNCT, V8, DOI 10.1186/1744-9081-8-2
Vaags AK, 2012, AM J HUM GENET, V90, P133, DOI 10.1016/j.ajhg.2011.11.025
Varoqueaux F, 2006, NEURON, V51, P741, DOI 10.1016/j.neuron.2006.09.003
Veliskova J, 2001, ANN NEUROL, V50, P596, DOI 10.1002/ana.1248
Verkerk AJMH, 2006, MOL PSYCHIATR, V11, P954, DOI 10.1038/sj.mp.4001877
Verkerk AJMH, 2003, GENOMICS, V82, P1, DOI 10.1016/S0888-7543(03)00097-1
Wang K, 2009, NATURE, V459, P528, DOI 10.1038/nature07999
Wright GJ, 2011, J NEUROCHEM, V117, P765, DOI 10.1111/j.1471-4159.2010.07141.x
Xu B, 2011, NAT GENET, V43, P864, DOI 10.1038/ng.902
Yadav R, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0032969
Yasumura M, 2012, J NEUROCHEM, V121, P705, DOI 10.1111/j.1471-4159.2011.07631.x
Yu P, 2005, GENOMICS, V86, P414, DOI 10.1016/j.ygeno.2005.06.008
Yuzaki M, 2004, CEREBELLUM, V3, P89, DOI 10.1080/14734220410028921
Zhang C, 2010, NEURON, V66, P403, DOI 10.1016/j.neuron.2010.04.008
Zhang HP, 2002, AM J HUM GENET, V70, P896, DOI 10.1086/339520
Zhang TY, 2010, ANNU REV PSYCHOL, V61, pC1
Zhang TY, 2010, ANNU REV PSYCHOL, V61, P439, DOI 10.1146/annurev.psych.60.110707.163625
NR 121
TC 13
Z9 13
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 2158-3188
J9 TRANSL PSYCHIAT
JI Transl. Psychiatr.
PD SEP
PY 2012
VL 2
AR e158
DI 10.1038/tp.2012.75
PG 13
WC Psychiatry
SC Psychiatry
GA 062DT
UT WOS:000312900000003
PM 22948383
ER
PT J
AU Dong, E
Gavin, DP
Chen, Y
Davis, J
AF Dong, E.
Gavin, D. P.
Chen, Y.
Davis, J.
TI Upregulation of TET1 and downregulation of APOBEC3A and APOBEC3C in the
parietal cortex of psychotic patients
SO TRANSLATIONAL PSYCHIATRY
LA English
DT Article
DE post-mortem brain; TET; AID/APOBECs; 5hmC; epigenetic
ID ACTIVE DNA DEMETHYLATION; PREFRONTAL CORTEX; MESSENGER-RNA;
SCHIZOPHRENIC-PATIENTS; EPIGENETIC MECHANISMS; BIPOLAR DISORDER; MAJOR
PSYCHOSIS; GENE-EXPRESSION; RELN PROMOTER; MOUSE-BRAIN
AB Increasing evidence suggests that epigenetic dysfunction may account for the alteration of gene transcription present in neuropsychiatric disorders such as schizophrenia (SZ), bipolar disorder (BP) and autism. Here, we studied the expression of the ten-eleven translocation (TET) gene family and activation-induced deaminase/apolipoprotein B mRNA-editing enzymes (AID/APOBEC) in the inferior parietal lobule (IPL) (BA39-40) and the cerebellum of psychotic (PSY) patients, depressed (DEP) patients and nonpsychiatric (CTR) subjects obtained from the Stanley Foundation Neuropathology Consortium Medical Research Institute. These two sets of enzymes have a critical role in the active DNA demethylation pathway. The results show that TET1, but not TET2 and TET3, mRNA and protein expression was increased (two-to threefold) in the IPL of the PSY patients compared with the CTR subjects. TET1 mRNA showed no change in the cerebellum. Consistent with the increase of TET1, the level of 5-hydroxymethylcytosine (5hmC) was elevated in the IPL of PSY patients but not in the other groups. Moreover, higher 5hmC levels were detected at the glutamic acid decarboxylase67 (GAD67) promoter only in the PSY group. This increase was inversely related to the decrease of GAD67 mRNA expression. Of 11 DNA deaminases measured, APOBEC3A mRNA was significantly decreased in the PSY and DEP patients, while APOBEC3C was decreased only in PSY patients. The other APOBEC mRNA studied failed to change. Increased TET1 and decreased APOBEC3A and APOBEC3C found in this study highlight the possible role of altered DNA demethylation mechanisms in the pathophysiology of psychosis. Translational Psychiatry (2012) 2, e159; doi:10.1038/tp.2012.86; published online 11 September 2012
C1 [Dong, E.; Gavin, D. P.; Chen, Y.; Davis, J.] Univ Illinois, Coll Med, Inst Psychiat, Dept Psychiat, Chicago, IL 60612 USA.
RP Dong, E (reprint author), Univ Illinois, Coll Med, Inst Psychiat, Dept Psychiat, 1601W Taylor St, Chicago, IL 60612 USA.
EM Edong@psych.uic.edu
FU University of Illinois at Chicago
FX We thank Drs A Guidotti, DR Grayson and P Tueting for their critical
reading and comments on the manuscript. We gratefully acknowledge the
support of ROAA fund from University of Illinois at Chicago.
CR Abdolmaleky HM, 2005, AM J MED GENET B, V134B, P60, DOI 10.1002/ajmg.b.30140
Akbarian S, 2010, CURR TOP BEHAV NEURO, V4, P611, DOI 10.1007/7854_2010_38
Andersen CL, 2004, CANCER RES, V64, P5245, DOI 10.1158/0008-5472.CAN-04-0496
Barreto G, 2007, NATURE, V445, P671, DOI 10.1038/nature05515
Benes FM, 2007, P NATL ACAD SCI USA, V104, P10164, DOI 10.1073/pnas.0703806104
Bhutani N, 2010, NATURE, V463, P1042, DOI 10.1038/nature08752
Bhutani N, 2011, CELL, V146, P866, DOI 10.1016/j.cell.2011.08.042
Buckley PF, 2011, CURR OPIN PSYCHIATR, V24, P122, DOI 10.1097/YCO.0b013e3283436eb7
Conticello SG, 2008, GENOME BIOL, V9, P2291
Dempster EL, 2006, BMC MED GENET, V7, DOI 10.1186/1471-2350-7-10
Dong E, 2010, EPIGENETICS-US, V5, P730, DOI 10.4161/epi.5.8.13053
Fatemi SH, 2005, SCHIZOPHR RES, V72, P109, DOI 10.1016/j.schres.2004.02.017
Gavin DP, 2012, NEUROBIOL DIS, V46, P255, DOI 10.1016/j.nbd.2011.12.008
Gavin DP, 2012, NEUROPSYCHOPHARMACOL, V37, P531, DOI 10.1038/npp.2011.221
Globisch D, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0015367
Goldstein JM, 1999, ARCH GEN PSYCHIAT, V56, P537, DOI 10.1001/archpsyc.56.6.537
Goll MG, 2005, ANNU REV BIOCHEM, V74, P481, DOI 10.1146/annurev.biochem.74.010904.153721
Grayson DR, 2005, P NATL ACAD SCI USA, V102, P9341, DOI 10.1073/pnas.0503736102
Guidotti A, 2000, ARCH GEN PSYCHIAT, V57, P1061, DOI 10.1001/archpsyc.57.11.1061
Guo JU, 2011, CELL, V145, P423, DOI 10.1016/j.cell.2011.03.022
Huang HS, 2007, PLOS ONE, V2, DOI 10.1371/journal.pone.0000809
Ito S, 2010, NATURE, V466, P1129, DOI 10.1038/nature09303
Iyer LM, 2009, CELL CYCLE, V8, P1698, DOI 10.4161/cc.8.11.8580
Jin SG, 2011, NUCLEIC ACIDS RES, V39, P5015, DOI 10.1093/nar/gkr120
Kriaucionis S, 2009, SCIENCE, V324, P929, DOI 10.1126/science.1169786
Lewis DA, 2005, NAT REV NEUROSCI, V6, P312, DOI 10.1038/nrn1648
Lintas C, 2010, NEUROREPORT, V21, P114, DOI 10.1097/WNR.0b013e328334b343
Ma DK, 2009, SCIENCE, V323, P1074, DOI 10.1126/science.1166859
Matrisciano F, 2011, MOL PHARMACOL, V80, P174, DOI 10.1124/mol.110.070896
Mill J, 2008, AM J HUM GENET, V82, P696, DOI 10.1016/j.ajhg.2008.01.008
Morgan HD, 2004, J BIOL CHEM, V279, P52353, DOI 10.1074/jbc.M407695200
Rai K, 2008, CELL, V135, P1201, DOI 10.1016/j.cell.2008.11.042
Robertson J, 2011, BIOCHEM BIOPH RES CO, V411, P40, DOI 10.1016/j.bbrc.2011.06.077
Roth TL, 2009, BBA-GEN SUBJECTS, V1790, P869, DOI 10.1016/j.bbagen.2009.06.009
Ruzicka WB, 2007, MOL PSYCHIATR, V12, P385, DOI 10.1038/sj.mp.4001954
Shulha HP, 2012, ARCH GEN PSYCHIAT, V69, P314, DOI 10.1001/archgenpsychiatry.2011.151
Song CX, 2011, NAT BIOTECHNOL, V29, P68, DOI 10.1038/nbt.1732
Szulwach KE, 2011, NAT NEUROSCI, V14, P1607, DOI 10.1038/nn.2959
Szyf M, 2009, ANNU REV PHARMACOL, V49, P243, DOI 10.1146/annurev-pharmtox-061008-103102
Tahiliani M, 2009, SCIENCE, V324, P930, DOI 10.1126/science.1170116
Tan L, 2012, DEVELOPMENT, V139, P1895, DOI 10.1242/dev.070771
Tochigi M, 2008, BIOL PSYCHIAT, V63, P530, DOI 10.1016/j.biopsych.2007.07.003
Torrey EF, 2000, SCHIZOPHR RES, V44, P151, DOI 10.1016/S0920-9964(99)00192-9
Torrey EF, 2007, SCHIZOPHR RES, V97, P215, DOI 10.1016/j.schres.2007.08.023
Uchida T, 2011, NEUROSCI RES, V69, P276, DOI 10.1016/j.neures.2010.12.010
Valinluck V, 2004, NUCLEIC ACIDS RES, V32, P4100, DOI 10.1093/nar/gkh739
Veldic M, 2005, P NATL ACAD SCI USA, V102, P2152, DOI 10.1073/pnas.0409665102
Veldic M, 2007, SCHIZOPHR RES, V91, P51, DOI 10.1016/j.schres.2006.11.029
Veldic M, 2004, P NATL ACAD SCI USA, V101, P348, DOI 10.1079/pnas.2637013100
Weickert CS, 2003, MOL PSYCHIATR, V8, P592, DOI 10.1038/sj.mp.4001308
Williams K, 2011, NATURE, V473, P343, DOI 10.1038/nature10066
Yildirim O, 2011, CELL, V147, P1498, DOI 10.1016/j.cell.2011.11.054
Zhang HK, 2010, CELL RES, V20, P1390, DOI 10.1038/cr.2010.156
Zhu JK, 2009, ANNU REV GENET, V43, P143, DOI 10.1146/annurev-genet-102108-134205
NR 54
TC 18
Z9 20
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 2158-3188
J9 TRANSL PSYCHIAT
JI Transl. Psychiatr.
PD SEP
PY 2012
VL 2
AR e159
DI 10.1038/tp.2012.86
PG 7
WC Psychiatry
SC Psychiatry
GA 062DT
UT WOS:000312900000004
PM 22948384
ER
PT J
AU Shahani, L
AF Shahani, Lokesh
TI Use of Lithium for Sexual Obsessions in Asperger's Disorder
SO JOURNAL OF NEUROPSYCHIATRY AND CLINICAL NEUROSCIENCES
LA English
DT Letter
ID CHILDREN; AUTISM
C1 SIU Sch Med, Dept Internal Med, Springfield, IL USA.
RP Shahani, L (reprint author), SIU Sch Med, Dept Internal Med, Springfield, IL USA.
EM lokesh83@hotmail.com
CR Cocarro EF, 1998, ARCH GEN PSYCHIAT, V54, P1081
Lenox RH, 2000, J CLIN PSYCHIAT, V61, P5
Leyfer OT, 2006, J AUTISM DEV DISORD, V36, P849, DOI 10.1007/s10803-006-0123-0
Pallanti S, 2002, J CLIN PSYCHIAT, V63, P559
STEIN DJ, 1992, J CLIN PSYCHIAT, V53, P267
Zandt F, 2007, J AUTISM DEV DISORD, V37, P251, DOI 10.1007/s10803-006-0158-2
NR 6
TC 0
Z9 0
PU AMER PSYCHIATRIC PUBLISHING, INC
PI ARLINGTON
PA 1000 WILSON BOULEVARD, STE 1825, ARLINGTON, VA 22209-3901 USA
SN 0895-0172
J9 J NEUROPSYCH CLIN N
JI J. Neuropsychiatr. Clin. Neurosci.
PD FAL
PY 2012
VL 24
IS 4
BP E17
EP E17
PG 1
WC Clinical Neurology; Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA 057WK
UT WOS:000312594700008
PM 23224465
ER
PT J
AU Liao, WL
Liu, YH
Wan, L
Chang, CT
Chen, CC
Chen, YH
Tsai, FJ
AF Liao, Wen-Ling
Liu, Yu-Huei
Wan, Lei
Chang, Chwen-Tzuei
Chen, Ching-Chu
Chen, Yung-Hsiang
Tsai, Fuu-Jen
TI Association of copy number variation in Fc gamma receptor IIIb gene with
risk of Graves' ophthalmopathy
SO SCIENCEASIA
LA English
DT Article
DE thyroid eye disease; autoimmune disease; goitre; exophthalmos
ID BREAST-CANCER; HUMAN HEALTH; DISEASE; FCGR3B; SUSCEPTIBILITY;
SCHIZOPHRENIA; AUTISM; PREDISPOSITION; AUTOIMMUNITY; EXPRESSION
AB The functional polymorphism that explains the established association of Fc gamma receptor IIIb (FCGR3B) with Graves' disease (GD) and Graves' ophthalmopathy (GO) remains unidentified, but copy number variation (CNV) might be relevant. The aim of this study was to determine whether CNV for FCGR3B is associated with GD and GO. Genotype analysis involved 624 GD patients, including 397 without GO (GD(nonGO)) and 227 with GO (GD(GO)), and 227 healthy controls. The relative copy number (CN) of FCGR3B was determined using a relative real-time quantitative polymerase chain reaction. Our findings indicated the distribution of the relative CN of FCGR3B significantly differed between the GD(GO) patients and the healthy controls (p = 0.02) but not between the total GD patients and the healthy control groups (p = 0.06). Individuals with less than 2 CN or more than 2 CN of FCGR3B were at significantly decreased risk of developing GD(GO). In addition, GD patients with less than 2 copies of FCGR3B were at reduced risk for developing nodular hyperplasia and vitiligo, but at increased risk for myxedema. Our results suggest that CNV of FCGR3B is associated with the development or progression of GD in Taiwan Chinese population.
C1 [Liu, Yu-Huei; Tsai, Fuu-Jen] China Med Univ Hosp, Dept Med Res & Med Genet, Taichung, Taiwan.
[Liao, Wen-Ling] China Med Univ Hosp, Ctr Personalized Med, Taichung, Taiwan.
[Liu, Yu-Huei; Wan, Lei; Chen, Yung-Hsiang] China Med Univ, Grad Inst Integrated Med, Taichung, Taiwan.
[Wan, Lei; Tsai, Fuu-Jen] China Med Univ, Sch Chinese Med, Taichung, Taiwan.
[Wan, Lei; Tsai, Fuu-Jen] Asia Univ, Dept Hlth & Nutr Biotechnol, Taichung, Taiwan.
[Chang, Chwen-Tzuei; Chen, Ching-Chu] China Med Univ Hosp, Dept Med, Div Endocrinol & Metab, Taichung, Taiwan.
[Chang, Chwen-Tzuei; Chen, Ching-Chu] China Med Univ, Coll Chinese Med, Dept Endocrinol & Metab, Taichung, Taiwan.
[Tsai, Fuu-Jen] China Med Univ Hosp, Dept Pediat, Taichung, Taiwan.
RP Tsai, FJ (reprint author), China Med Univ Hosp, Dept Med Res & Med Genet, Taichung, Taiwan.
EM d0704@www.cmuh.org.tw
RI liu, yuhuei/D-2539-2014
OI liu, yuhuei/0000-0002-3603-868X
FU China Medical University, Taichung, Taiwan [CMU-98-asia-04,
DMR-101-118]; National Science Council, Taipei, Taiwan
[98-2320-B-039-008-MY3]
FX Wen-Ling Liao and Yu-Huei Liu contributed equally to this work. We thank
Hsin-Hui Chen for the technical assistance in preparation of DNA and
analysing the variations. This study was supported by research grants
from China Medical University, Taichung (CMU-98-asia-04 and
DMR-101-118), Taiwan and 98-2320-B-039-008-MY3 from National Science
Council, Taipei, Taiwan.
CR Bartalena L, 2005, J CLIN ENDOCR METAB, V90, P5497, DOI 10.1210/jc.2005-1553
Bednarczuk T, 2007, CLIN ENDOCRINOL, V67, P3, DOI 10.1111/j.1365-2265.2007.02854.x
Fanciulli M, 2007, NAT GENET, V39, P721, DOI 10.1038/ng2046
Field SF, 2009, NAT MED, V15, P1115, DOI 10.1038/nm1009-1115
Gianoukakis AG, 2008, THYROID, V18, P953, DOI 10.1089/thy.2007.0405
Glessner JT, 2009, NATURE, V459, P569, DOI 10.1038/nature07953
Huber AK, 2011, THYROID, V21, P69, DOI 10.1089/thy.2010.0262
Khoo TK, 2007, THYROID, V17, P1013, DOI 10.1089/thy.2007.0185
Kloprogge S, 2005, EUR J OPHTHALMOL, V15, P315
Kraimps JL, 2000, BRIT J SURG, V87, P1111, DOI 10.1046/j.1365-2168.2000.01504.x
Kuriyan AE, 2008, CURR OPIN OPHTHALMOL, V19, P499, DOI 10.1097/ICU.0b013e3283131557
Li X, 2009, GENES IMMUN, V10, P380, DOI 10.1038/gene.2009.35
Liao WL, 2011, OPHTHALMOLOGY, V118, P553, DOI 10.1016/j.ophtha.2010.07.021
Liu WN, 2009, CANCER RES, V69, P2176, DOI 10.1158/0008-5472.CAN-08-3151
Livak KJ, 2001, METHODS, V25, P402, DOI 10.1006/meth.2001.1262
Lv J, 2010, LUPUS, V19, P158, DOI 10.1177/0961203309350319
Maestrini E, 2010, MOL PSYCHIATR, V15, P954, DOI 10.1038/mp.2009.34
Mamtani M, 2010, GENES IMMUN, V11, P155, DOI 10.1038/gene.2009.71
Marques RB, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0013173
McKinney C, 2010, ANN RHEUM DIS, V69, P1711, DOI 10.1136/ard.2009.123588
Niederer HA, 2010, HUM MOL GENET, V19, P3282, DOI 10.1093/hmg/ddq216
Nielsen KV, 2008, ACTA ONCOL, V47, P725, DOI 10.1080/02841860801995396
Noor A, 2009, PSYCHIAT GENET, V19, P154, DOI 10.1097/YPG.0b013e32832a4fe5
Perros P., 2009, BRIT MED J, V338, P645
Schaschl H, 2009, CLIN EXP IMMUNOL, V156, P12, DOI 10.1111/j.1365-2249.2008.03865.x
Shlien A, 2008, P NATL ACAD SCI USA, V105, P11264, DOI 10.1073/pnas.0802970105
Speleman F, 2008, CYTOGENET GENOME RES, V123, P176, DOI 10.1159/000184706
St Clair D, 2009, SCHIZOPHRENIA BULL, V35, P9, DOI 10.1093/schbul/sbn147
Sutrala SR, 2007, SCHIZOPHR RES, V96, P93, DOI 10.1016/j.schres.2007.07.029
Sutrala SR, 2008, AM J MED GENET B, V147B, P606, DOI 10.1002/ajmg.b.30645
Sykes NH, 2009, EUR J HUM GENET, V17, P1347, DOI 10.1038/ejhg.2009.47
Tam GWC, 2009, BIOL PSYCHIAT, V66, P1005, DOI 10.1016/j.biopsych.2009.07.027
Tchatchou S, 2008, CYTOGENET GENOME RES, V123, P183, DOI 10.1159/000184707
Venkatachalam R, 2008, CYTOGENET GENOME RES, V123, P188, DOI 10.1159/000184708
Wain LV, 2009, LANCET, V374, P340, DOI 10.1016/S0140-6736(09)60249-X
Willcocks LC, 2008, J EXP MED, V205, P1573, DOI 10.1084/jem.20072413
Zhang F, 2009, ANNU REV GENOM HUM G, V10, P451, DOI 10.1146/annurev.genom.9.081307.164217
Zhou XJ, 2010, INT IMMUNOL, V22, P45, DOI 10.1093/intimm/dxp113
NR 38
TC 0
Z9 0
PU THAILANDS NATL SCIENCE & TECHNOLOGY DEVELOPMENT AGENCY
PI BANGKOK
PA PUBLIC INFORMATION DEPT, 73/1 RAMA VI RD, RAJDHEVEE, BANGKOK, 00000,
THAILAND
SN 1513-1874
J9 SCIENCEASIA
JI Scienceasia
PD SEP
PY 2012
VL 38
IS 3
BP 256
EP 261
DI 10.2306/scienceasia1513-1874.2012.38.256
PG 6
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 056WC
UT WOS:000312521100005
ER
PT J
AU Schlinger, HD
AF Schlinger, Henry D., Jr.
TI Untitled
SO BEHAVIOR ANALYST
LA English
DT Editorial Material
ID VARIABILITY; SEQUENCES; BEHAVIOR; AUTISM
CR Critchfield TS, 2011, BEHAV ANALYST, V34, P297
Harris S., 2010, MORAL LANDSCAPE SCI
Heldt Juliane, 2012, Anal Verbal Behav, V28, P131
Lee R, 2002, J APPL BEHAV ANAL, V35, P391, DOI 10.1901/jaba.2002.35-391
MACHADO A, 1993, BEHAV PROCESS, V30, P103, DOI 10.1016/0376-6357(93)90002-9
Machado A, 1997, J EXP ANAL BEHAV, V68, P1, DOI 10.1901/jeab.1997.68-1
Miller N, 2000, J APPL BEHAV ANAL, V33, P151, DOI 10.1901/jaba.2000.33-151
Neuringer A, 2004, AM PSYCHOL, V59, P891, DOI 10.1037/0003-066X.59.9.891
PAGE S, 1985, J EXP PSYCHOL ANIM B, V11, P429, DOI 10.1037//0097-7403.11.3.429
Pierce W D, 1980, Behav Anal, V3, P1
PRYOR KW, 1969, J EXP ANAL BEHAV, V12, P653, DOI 10.1901/jeab.1969.12-653
Skinner B. F., 1987, FURTHER REFLECTION
Susa Carrie, 2012, Anal Verbal Behav, V28, P125
NR 13
TC 0
Z9 0
PU SOC ADVANCEMENT BEHAVIOR ANALYSIS
PI KALAMAZOO
PA WESTERN MICHIGAN UNIV, 260 WOOD HALL, KALAMAZOO, MI 49008-5052 USA
SN 0738-6729
J9 BEHAV ANALYST
JI Behav. Anal.
PD FAL
PY 2012
VL 35
IS 2
BP 149
EP 151
PG 3
WC Psychology, Clinical
SC Psychology
GA 050IY
UT WOS:000312048200001
PM 23450911
ER
PT J
AU Iourov, IY
Vorsanova, SG
Yurov, YB
AF Iourov, Ivan Y.
Vorsanova, Svetlana G.
Yurov, Yuri B.
TI Single Cell Genomics of the Brain: Focus on Neuronal Diversity and
Neuropsychiatric Diseases
SO CURRENT GENOMICS
LA English
DT Article
DE Aneuploidy; Brain; Chromosome instability; Disease; Epigenome; Genomic
variations; Single cell genomics; Somatic mosaicism
ID ATAXIA-TELANGIECTASIA BRAIN; IN-SITU HYBRIDIZATION; COPY NUMBER
VARIATION; ALZHEIMERS-DISEASE; CHROMOSOME INSTABILITY; SOMATIC
MOSAICISM; INTERPHASE CHROMOSOMES; HUMAN TISSUES; NEURODEGENERATIVE
DISEASES; MOLECULAR CYTOGENETICS
AB Single cell genomics has made increasingly significant contributions to our understanding of the role that somatic genome variations play in human neuronal diversity and brain diseases. Studying intercellular genome and epigenome variations has provided new clues to the delineation of molecular mechanisms that regulate development, function and plasticity of the human central nervous system (CNS). It has been shown that changes of genomic content and epigenetic profiling at single cell level are involved in the pathogenesis of neuropsychiatric diseases (schizophrenia, mental retardation (intellectual/leaning disability), autism, Alzheimer's disease etc.). Additionally, several brain diseases were found to be associated with genome and chromosome instability (copy number variations, aneuploidy) variably affecting cell populations of the human CNS. The present review focuses on the latest advances of single cell genomics, which have led to a better understanding of molecular mechanisms of neuronal diversity and neuropsychiatric diseases, in the light of dynamically developing fields of systems biology and "omics".
C1 [Iourov, Ivan Y.; Vorsanova, Svetlana G.; Yurov, Yuri B.] Russian Acad Med Sci, Natl Res Ctr Mental Hlth, Moscow 119152, Russia.
[Iourov, Ivan Y.; Vorsanova, Svetlana G.; Yurov, Yuri B.] Inst Pediat & Children Surg, Moscow, Russia.
[Vorsanova, Svetlana G.; Yurov, Yuri B.] Moscow City Univ Psychol & Educ, Ctr Neurobiol Diag Genet Psychiat Disorders, Moscow, Russia.
RP Iourov, IY (reprint author), Russian Acad Med Sci, Natl Res Ctr Mental Hlth, Zagorodnoe Sh 2, Moscow 119152, Russia.
EM ivan_iourov@yahoo.com
RI Iourov, Ivan/O-7684-2014
OI Iourov, Ivan/0000-0002-4134-8367
FU DLR/BMBF (Deutsches Luft- und Raumfahrtszentrum/ Bundesministerium fur
Bildung und Forschung) [RUS 09/006, RUS 11/002]
FX The article is dedicated to Dr. Ilia V. Soloviev. The authors are
supported by two grants from DLR/BMBF (Deutsches Luft- und
Raumfahrtszentrum/ Bundesministerium fur Bildung und Forschung) RUS
09/006 and RUS 11/002.
CR Akbarian S, 2010, CURR TOP BEHAV NEURO, V4, P611, DOI 10.1007/7854_2010_38
Ueberham Uwe, 2005, Current Drug Targets - CNS and Neurological Disorders, V4, P293, DOI 10.2174/1568007054038175
Arendt T, 2010, AM J PATHOL, V177, P15, DOI 10.2353/ajpath.2010.090955
Arendt T, 2009, INT J MOL SCI, V10, P1609, DOI 10.3390/ijms10041609
Astolfi PA, 2010, CURR GENOMICS, V11, P379, DOI 10.2174/138920210793175949
Bejjani BA, 2008, ANNU REV GENOM HUM G, V9, P71, DOI 10.1146/annurev.genom.9.081307.164207
Boeras DI, 2008, NEUROBIOL AGING, V29, P319, DOI 10.1016/j.neurobiolaging.2006.10.027
Boguski MS, 2004, NAT NEUROSCI, V7, P429, DOI 10.1038/nn1232
Borland LM, 2008, ANNU REV ANAL CHEM, V1, P191, DOI 10.1146/annurev.anchem.1.031207.113100
Borysov SI, 2011, CELL CYCLE, V10, P1397, DOI 10.4161/cc.10.9.15478
Bourdon V, 2001, J MED GENET, V38, P867, DOI 10.1136/jmg.38.12.867
Caudle WM, 2010, EXPERT REV NEUROTHER, V10, P925, DOI [10.1586/ern.10.54, 10.1586/ERN.10.54]
Chao TC, 2008, J R SOC INTERFACE, V5, pS139, DOI 10.1098/rsif.2008.0233.focus
Chen JM, 2010, MOL NEURODEGENER, V5, DOI 10.1186/1750-1326-5-60
Cheng JQ, 2011, GENOME BIOL, V12, DOI 10.1186/gb-2011-12-8-r80
Chuang HY, 2010, ANNU REV CELL DEV BI, V26, P721, DOI 10.1146/annurev-cellbio-100109-104122
Clarke A, 2011, HUM GENET, V130, P27, DOI 10.1007/s00439-011-0988-7
Costanzo M, 2010, SCIENCE, V327, P425, DOI 10.1126/science.1180823
Counts SE, 2008, NEURODEGENER DIS, V5, P228, DOI 10.1159/000113710
Darzacq X, 2009, ANNU REV BIOPHYS, V38, P173, DOI 10.1146/annurev.biophys.050708.133728
De S, 2011, TRENDS GENET, V27, P217, DOI 10.1016/j.tig.2011.03.002
Dierssen M, 2009, PHYSIOL REV, V89, P887, DOI 10.1152/physrev.00032.2007
Diks SH, 2004, TRENDS MOL MED, V10, P574, DOI 10.1016/j.molmed.2004.10.005
Driver Jane A, 2010, Curr Aging Sci, V3, P158
Elstner M, 2009, ANN NEUROL, V66, P792, DOI 10.1002/ana.21780
Faggioli F, 2011, MECH AGEING DEV, V132, P429, DOI 10.1016/j.mad.2011.04.008
Fickelscher I, 2007, PRENATAL DIAG, V27, P783, DOI 10.1002/pd.1776
Frade JM, 2010, CELL CYCLE, V9, P1934
Franke L, 2006, AM J HUM GENET, V78, P1011, DOI 10.1086/504300
Galvin JE, 2004, NEUROCHEM RES, V29, P1041, DOI 10.1023/B:NERE.0000023592.53769.4d
Geller LN, 1999, NEUROBIOL DIS, V6, P167, DOI 10.1006/nbdi.1999.0236
Geschwind DH, 2009, NATURE, V461, P908, DOI 10.1038/nature08537
Ginsberg S. D., 2011, NEUROBIOL DIS, V45, P99
Ginsberg Stephen D, 2006, NeuroRx, V3, P302, DOI 10.1007/BF03206654
Gräff Johannes, 2011, Physiol Rev, V91, P603, DOI 10.1152/physrev.00012.2010
Granic A, 2010, MOL BIOL CELL, V21, P511, DOI 10.1091/mbc.E09-10-0850
Hehir-Kwa JY, 2010, PLOS COMPUT BIOL, V6, DOI 10.1371/journal.pcbi.1000752
Heinemann M, 2011, CURR OPIN BIOTECH, V22, P26, DOI 10.1016/j.copbio.2010.09.008
Hemby SE, 2002, ARCH GEN PSYCHIAT, V59, P631, DOI 10.1001/archpsyc.59.7.631
Heng HHQ, 2011, GENOMICS, V98, P242, DOI 10.1016/j.ygeno.2011.05.008
Heng Henry H Q, 2010, Nat Rev Genet, V11, P813, DOI 10.1038/nrg2809-c3
Herculano-Houzel S, 2009, FRONT HUM NEUROSCI, V3, DOI 10.3389/neuro.09.031.2009
Huang B, 2009, ANNU REV BIOCHEM, V78, P993, DOI 10.1146/annurev.biochem.77.061906.092014
Hulten MA, 2008, MOL CYTOGENET, V1, DOI 10.1186/1755-8166-1-21
Hulten MA, 2010, CURR GENOMICS, V11, P409, DOI 10.2174/138920210793176056
Iourov IY, 2009, MED HYPOTHESES, V72, P615, DOI 10.1016/j.mehy.2008.12.003
Iourov IY, 2010, CURR GENOMICS, V11, P387, DOI 10.2174/138920210793176065
Iourov Ivan Y., 2009, P301, DOI 10.1007/978-3-540-70581-9_27
Iourov IY, 2009, NEUROBIOL DIS, V34, P212, DOI 10.1016/j.nbd.2009.01.003
Iourov Ivan Y, 2008, Recent Pat DNA Gene Seq, V2, P6
Iourov IY, 2008, MED HYPOTHESES, V70, P456, DOI 10.1016/j.mehy.2007.05.037
Iourov IY, 2006, INT REV CYTOL, V249, P143, DOI 10.1016/S0074-7696(06)49003-3
Iourov IY, 2009, HUM MOL GENET, V18, P2656, DOI 10.1093/hmg/ddp207
Iourov Ivan Y., 2006, V334, P123
Iourov I.Y., 2010, RUS J GENET, V46, P1171
Iourov IY, 2011, NEURODEGENER DIS, V8, P35, DOI 10.1159/000315398
Iourov IY, 2007, BIOMOL ENG, V24, P415, DOI 10.1016/j.bioeng.2007.05.003
Iourov IY, 2008, MOL CYTOGENET, V1, DOI 10.1186/1755-8166-1-26
Iourov Ivan Y., 2009, P75, DOI 10.1007/978-3-540-70581-9_7
Iourov IY, 2008, CURR GENOMICS, V9, P452, DOI 10.2174/138920208786241216
Iourov IY, 2006, CURR GENOMICS, V7, P435, DOI 10.2174/138920206779116756
Iourov IY, 2006, CHROMOSOME RES, V14, P223, DOI 10.1007/s10577-006-1037-6
Islam S, 2011, GENOME RES, V21, P1160, DOI 10.1101/gr.110882.110
Kahle JJ, 2011, HUM MOL GENET, V20, P510, DOI 10.1093/hmg/ddq496
Kalisky T, 2011, NAT METHODS, V8, P311, DOI [10.1038/nmeth0411-311, 10.1038/nmeth0411-308]
Kingsbury MA, 2005, P NATL ACAD SCI USA, V102, P6143, DOI 10.1073/pnas.0408171102
Koirala S, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009198
Lafarga M, 2009, CHROMOSOMA, V118, P437, DOI 10.1007/s00412-009-0212-x
Le Caignec C, 2006, NUCLEIC ACIDS RES, V34, DOI 10.1093/nar/gkl336
Lee JM, 2010, BMC SYST BIOL, V4, DOI 10.1186/1752-0509-4-29
Le Gac S, 2010, TRENDS BIOTECHNOL, V28, P55, DOI 10.1016/j.tibtech.2009.10.005
Levsky JM, 2003, J CELL SCI, V116, P2833, DOI 10.1242/jcs.00633
Liehr Thomas, 2002, Current Molecular Medicine (Hilversum), V2, P283, DOI 10.2174/1566524024605725
Liehr T, 2009, FLUORESCENCE SITU HY
Liehr T, 2010, MOL CYTOGENET, V3, DOI 10.1186/1755-8166-3-8
Lima-de-Faria A., 1969, FRONTIERS BIOL, V15
Los Frans J., 2004, Human Reproduction Update, V10, P79, DOI 10.1093/humupd/dmh005
Lu CM, 2009, J HISTOCHEM CYTOCHEM, V57, P587, DOI 10.1369/jhc.2009.953638
MacMillan HR, 2011, THEOR BIOSCI, V130, P31, DOI 10.1007/s12064-010-0107-7
Manvelyan M, 2008, MOL CYTOGENET, V1, DOI 10.1186/1755-8166-1-9
Mattsson G, 2007, J MOL DIAGN, V9, P479, DOI 10.2353/jmoldx.2007.070041
Mazarei G, 2010, HUM MOL GENET, V19, P609, DOI 10.1093/hmg/ddp527
Migliore L, 2011, MUTAGENESIS, V26, P85, DOI 10.1093/mutage/geq067
Mkrtchyan H, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009591
Mosch B, 2007, J NEUROSCI, V27, P6859, DOI 10.1523/JNEUROSCI.0379-07.2007
Muotri AR, 2006, NATURE, V441, P1087, DOI 10.1038/nature04959
Oka A, 1998, NEUROSCI LETT, V252, P195, DOI 10.1016/S0304-3940(98)00576-X
Oldham MC, 2008, NAT NEUROSCI, V11, P1271, DOI 10.1038/nn.2207
Pamphlett R, 2011, MUSCLE NERVE, V44, P492, DOI 10.1002/mus.22095
Piotrowski A, 2008, HUM MUTAT, V29, P1118, DOI 10.1002/humu.20815
Robberech C, 2010, CURR GENOMICS, V11, P397, DOI 10.2174/138920210793175967
Samaco RC, 2004, HUM MOL GENET, V13, P629, DOI 10.1093/hmg/ddh063
Sgaramella V, 2010, DNA REPAIR, V9, P470, DOI 10.1016/j.dnarep.2009.11.011
Sheltzer JM, 2011, TRENDS GENET, V27, P446, DOI 10.1016/j.tig.2011.07.003
Shultz D.J., 2007, P NATL ACAD SCI USA, V104, P13187
Simunovic F, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0008856
Singer T, 2010, TRENDS NEUROSCI, V33, P345, DOI 10.1016/j.tins.2010.04.001
Soen Y, 2006, MOL SYST BIOL, V2, DOI 10.1038/msb4100076
Soler-Lopez M, 2011, GENOME RES, V21, P364, DOI 10.1101/gr.114280.110
Spaethling J., 2008, NEUROBIOLOGY MOL BAS, V1, P3
Spremo-Potparevic B, 2011, ARCH BIOL SCI, V63, P603, DOI 10.2298/ABS1103603P
Stahlberg A, 2011, NUCLEIC ACIDS RES, V39, DOI 10.1093/nar/gkq1182
Sun J, 2010, CANCER RES, V70, P6128, DOI 10.1158/0008-5472.CAN-10-0076
Swami M, 2009, HUM MOL GENET, V18, P3039, DOI 10.1093/hmg/ddp242
Takizawa T, 2008, TRENDS NEUROSCI, V31, P343, DOI 10.1016/j.tins.2008.03.005
Tang FC, 2011, NAT METHODS, V8, pS6, DOI [10.1038/nmeth.1557, 10.1038/NMETH.1557]
Taraska JW, 2010, NEURON, V66, P170, DOI 10.1016/j.neuron.2010.02.002
Thatcher KN, 2005, HUM MOL GENET, V14, P785, DOI 10.1093/hmg/ddi073
Tietjen I, 2003, NEURON, V38, P161, DOI 10.1016/S0896-6273(03)00229-0
Toomre D, 2010, ANNU REV CELL DEV BI, V26, P285, DOI 10.1146/annurev-cellbio-100109-104048
Vanneste E, 2009, NAT MED, V15, P577, DOI 10.1038/nm.1924
Vidal M, 2011, CELL, V144, P986, DOI 10.1016/j.cell.2011.02.016
Vissers LELM, 2010, J MED GENET, V47, P289, DOI 10.1136/jmg.2009.072942
Vorsanova SG, 2010, MOL CYTOGENET, V3, DOI 10.1186/1755-8166-3-1
Vorsanova SG, 2010, CURR GENOMICS, V11, P440, DOI 10.2174/138920210793176010
Vorsanova SG, 2010, RUSS J GENET+, V46, P1197, DOI 10.1134/S1022795410100133
Vorsanova SG, 2001, BRAIN DEV-JPN, V23, pS196, DOI 10.1016/S0387-7604(01)00347-3
Vorsanova SG, 2005, J HISTOCHEM CYTOCHEM, V53, P375, DOI 10.1369/jhc.4A6424.2005
Wang DJ, 2010, TRENDS BIOTECHNOL, V28, P281, DOI 10.1016/j.tibtech.2010.03.002
Wang L, 2007, J NEUROSCI, V27, P12555, DOI 10.1523/JNEUROSCI.3681-07.2007
Wang W, 2009, PROG NEUROBIOL, V89, P1, DOI 10.1016/j.pneurobio.2009.01.007
Weier H.U., 2010, NEW TRENDS MICROSCOP, P42
Weier HUG, 2009, J PHYSIOL PHARMACOL, V60, P47
Weier JF, 2010, CURR GENOMICS, V11, P402, DOI 10.2174/138920210793175994
Weier JF, 2005, DEV BIOL, V279, P420, DOI 10.1016/j.ydbio.2004.12.035
Westra JW, 2010, J COMP NEUROL, V518, P3981, DOI 10.1002/cne.22436
Westra JW, 2009, NEURODEGENER DIS, V6, P221, DOI 10.1159/000236901
Westra JW, 2008, J COMP NEUROL, V507, P1944, DOI 10.1002/cne.21648
Woo YH, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0012158
Yang AH, 2003, J NEUROSCI, V23, P10454
Yuen RKC, 2011, PLACENTA, V32, pS136, DOI 10.1016/j.placenta.2011.01.003
Yurov YB, 2008, SCHIZOPHR RES, V98, P139, DOI 10.1016/j.schres.2007.07.035
Yurov YB, 2010, RUSS J GENET+, V46, P1194, DOI 10.1134/S1022795410100121
Yurov YB, 2005, J HISTOCHEM CYTOCHEM, V53, P385, DOI 10.1369/jhc.4A6430.2005
Yurov YB, 2009, MOL CYTOGENET, V2, DOI 10.1186/1755-8166-2-23
Yurov YB, 2007, J MED GENET, V44, P521, DOI 10.1136/jmg.2007.049312
Yurov YB, 2001, BRAIN DEV-JPN, V23, pS186, DOI 10.1016/S0387-7604(01)00363-1
Yurov YB, 2007, PLOS ONE, V2, DOI 10.1371/journal.pone.0000558
Yurov YB, 2010, CURR GENOMICS, V11, P420, DOI 10.2174/138920210793175958
Zekanowski C, 2009, ACTA NEUROBIOL EXP, V69, P232
Zoghbi HY, 2010, NEURON, V68, P165, DOI 10.1016/j.neuron.2010.10.015
NR 141
TC 9
Z9 11
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
EMIRATES
SN 1389-2029
J9 CURR GENOMICS
JI Curr. Genomics
PD SEP
PY 2012
VL 13
IS 6
BP 477
EP 488
PG 12
WC Biochemistry & Molecular Biology; Genetics & Heredity
SC Biochemistry & Molecular Biology; Genetics & Heredity
GA 995KA
UT WOS:000308005700009
PM 23449087
ER
PT J
AU Ghanizadeh, A
AF Ghanizadeh, A.
TI Hydrogen as a novel hypothesized emerging treatment for oxidative stress
in autism
SO EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
LA English
DT Letter
ID MITOCHONDRIAL DYSFUNCTION; METABOLIC BIOMARKERS; MOLECULAR-HYDROGEN;
ANTIOXIDANT; CONSUMPTION; INHALATION; PREVENTS; CHILDREN; INJURY; MICE
C1 [Ghanizadeh, A.] Shiraz Univ Med Sci, Res Ctr Psychiat & Behav Sci, Sch Med, Shiraz, Iran.
[Ghanizadeh, A.] Shiraz Univ Med Sci, Sch Med, Dept Psychiat, Shiraz, Iran.
RP Ghanizadeh, A (reprint author), Shiraz Univ Med Sci, Res Ctr Psychiat & Behav Sci, Sch Med, Shiraz, Iran.
EM ghanizad@sina.tums.ac.ir
CR ABRAINI JH, 1994, J APPL PHYSIOL, V76, P1113
Al-Gadani Y, 2009, CLIN BIOCHEM, V42, P1032, DOI 10.1016/j.clinbiochem.2009.03.011
Buchholz BM, 2008, AM J TRANSPLANT, V8, P2015, DOI 10.1111/j.1600-6143.2008.02359.x
Frye RE, 2011, PEDIATR RES, V69, p41R, DOI 10.1203/PDR.0b013e318212f16b
Fu Y, 2009, NEUROSCI LETT, V453, P81, DOI 10.1016/j.neulet.2009.02.016
FuJiTA K, 2009, PLOS ONE, V4, P7247
Fukuda KI, 2007, BIOCHEM BIOPH RES CO, V361, P670, DOI 10.1016/j.bbrc.2007.07.088
Giulivi C, 2010, JAMA-J AM MED ASSOC, V304, P2389, DOI 10.1001/jama.2010.1706
HALLIWELL B, 1993, AM J CLIN NUTR, V57, P715
James SJ, 2004, AM J CLIN NUTR, V80, P1611
Kannan K, 2000, PATHOPHYSIOLOGY, V7, P153, DOI DOI 10.1016/S0928-4680(00)00053-5
Kern JK, 2006, J TOXICOL ENV HEAL B, V9, P485, DOI 10.1080/10937400600882079
Manaenko A, 2011, ACTA NEUROCHIR SUPPL, V111, P179, DOI 10.1007/978-3-7091-0693-8_30
MELNYK S, 2011, J AUTISM DEV DISORD, P26
Mostafa GA, 2010, J NEUROIMMUNOL, V219, P114, DOI 10.1016/j.jneuroim.2009.12.003
Nagata K, 2009, NEUROPSYCHOPHARMACOL, V34, P501, DOI 10.1038/npp.2008.95
Ohsawa I, 2008, BIOCHEM BIOPH RES CO, V377, P1195, DOI 10.1016/j.bbrc.2008.10.156
Ohsawa I, 2007, NAT MED, V13, P688, DOI 10.1038/nm1577
OHTA S., 2011, BIOCHIM BIOPHYS ACTA, P20
Palmieri L, 2010, BBA-BIOENERGETICS, V1797, P1130, DOI 10.1016/j.bbabio.2010.04.018
Sauer H, 2001, CELL PHYSIOL BIOCHEM, V11, P173, DOI 10.1159/000047804
Sogut S, 2003, CLIN CHIM ACTA, V331, P111, DOI 10.1016/S0009-8981(03)00119-0
NR 22
TC 2
Z9 2
PU VERDUCI PUBLISHER
PI ROME
PA VIA GREGORIO VII, ROME, 186-00165, ITALY
SN 1128-3602
J9 EUR REV MED PHARMACO
JI Eur. Rev. Med. Pharmacol. Sci.
PD SEP
PY 2012
VL 16
IS 9
BP 1313
EP 1314
PG 2
WC Pharmacology & Pharmacy
SC Pharmacology & Pharmacy
GA 028EN
UT WOS:000310405700026
PM 23047522
ER
PT J
AU Silton, NR
Fogel, J
AF Silton, Nava R.
Fogel, Joshua
TI ENHANCING POSITIVE BEHAVIORAL INTENTIONS OF TYPICAL CHILDREN TOWARDS
CHILDREN WITH AUTISM
SO JOURNAL OF COGNITIVE AND BEHAVIORAL PSYCHOTHERAPIES
LA English
DT Article
DE autistic disorder; attitude; intentions; peer group; schools
ID SOCIAL-INTERACTION; SPECTRUM DISORDER; PLANNED BEHAVIOR; PEER;
ATTITUDES; GENDER; INTERVENTION; SCHOOL; PRESCHOOLERS; INDIVIDUALS
AB This experimental study examined the potential additive benefit of peer strategies (PS) and strengths information (SI) over descriptive and explanatory (D+E) information in enhancing typical children's behavioral intentions and cognitive attitudes towards children with autism. Participants were 158 typical students from fourth, fifth and sixth grades who were assigned to groups viewing videos about autism: Video I (D+E), Video II (D+E+PS), Video III (D+E+SI) or Video IV (D+E+PS+SI). Analyses indicated significant differences in positive behavioral intentions but no attitude differences after watching the videos. Participants who viewed videos incorporating peer strategies (Videos II and IV) had significantly greater positive behavioral intentions than those who viewed the video incorporating strengths information (Video III). Video interventions can help enhance typical children's behavioral intentions towards children with autism.
C1 [Silton, Nava R.] Marymt Manhattan Coll, New York, NY USA.
[Fogel, Joshua] CUNY Brooklyn Coll, Brooklyn, NY 11210 USA.
RP Silton, NR (reprint author), Marymt Manhattan Coll, New York, NY USA.
EM nsilton@mmm.edu
CR AJZEN I, 1991, ORGAN BEHAV HUM DEC, V50, P179, DOI 10.1016/0749-5978(91)90020-T
Bandura A., 1977, SOCIAL LEARNING THEO
Bauminger N, 2008, J AUTISM DEV DISORD, V38, P1211, DOI 10.1007/s10803-007-0501-2
Bell SK, 2000, J PEDIATR PSYCHOL, V25, P137, DOI 10.1093/jpepsy/25.3.137
Bonnel A, 2003, J COGNITIVE NEUROSCI, V15, P226, DOI 10.1162/089892903321208169
Boyatzis CJ, 1999, SEX ROLES, V40, P93, DOI 10.1023/A:1018882417926
Campbell J. M., 2006, ANN M AM PSYCH ASS A
Campbell JM, 2008, J AUTISM DEV DISORD, V38, P1598, DOI 10.1007/s10803-007-0534-6
Campbell JM, 2004, RES DEV DISABIL, V25, P321, DOI 10.1016/j.ridd.2004.01.005
Centers for Disease Control and Prevention, 2012, AUT SPECTR DIS DAT S
Chambres P, 2008, J AUTISM DEV DISORD, V38, P1320, DOI 10.1007/s10803-007-0519-5
Cheatham S., 1995, EDUC TRAIN MENT RET, V30, P245
Dasgupta N, 2008, SOC COGNITION, V26, P112, DOI 10.1521/soco.2008.26.1.112
Deschryver O., 2004, DISS ABSTR INT A, V64, P3246
DiSalvo C., 2002, FOCUS AUTISM OTHER D, V17, P198, DOI DOI 10.1177/10883576020170040201
Elder J., 2006, DIFFERENT ME MY BOOK
ETAUGH C, 1992, SEX ROLES, V26, P129, DOI 10.1007/BF00289754
Fridell SR, 2006, ARCH SEX BEHAV, V35, P729, DOI 10.1007/s10508-006-9085-8
Friedrich S, 1996, J PEDIATR PSYCHOL, V21, P307, DOI 10.1093/jpepsy/21.3.307
GOLDSTEIN H, 1992, J APPL BEHAV ANAL, V25, P289, DOI 10.1901/jaba.1992.25-289
Gonzalez-Lopez A., 1997, FOCUS AUTISM OTHER D, V12, P2
Grandin Temple, 2005, ANIMALS TRANSLATION
Gray DE, 2002, SOCIOL HEALTH ILL, V24, P734, DOI 10.1111/1467-9566.00316
Haddon M., 2003, CURIOUS INCIDENT DOG
Heider F., 1958, PSYCHOL INTERPERSONA
Hollander E, 1999, AM J PSYCHIAT, V156, P317
Iavarone A, 2007, J AUTISM DEV DISORD, V37, P775, DOI 10.1007/s10803-006-0190-2
Kelley H. H., 1967, NEBRASKA S MOTIVATIO
Mackay T, 2007, J INTELLECT DEV DIS, V32, P279, DOI 10.1080/13668250701689280
MADDEN TJ, 1992, PERS SOC PSYCHOL B, V18, P3, DOI 10.1177/0146167292181001
Magill-Evans J, 2001, AUTISM, V10, P609
Morgan SB, 1996, J DEV PHYS DISABIL, V8, P29, DOI 10.1007/BF02578438
Mottron L, 2006, J AUTISM DEV DISORD, V36, P27, DOI 10.1007/s10803-005-0040-7
MOTTRON L, 1995, PSYCHOL MED, V25, P639
Notbohm E., 2005, 10 THINGS EVERY CHIL
Odom S. L., 1993, EXCEPT CHILDREN, V60, P226
ODOM SL, 1991, J SPEC EDUC, V25, P26
ODOM SL, 1986, J APPL BEHAV ANAL, V19, P59, DOI 10.1901/jaba.1986.19-59
Owen-Deschryver J. S., 2004, DISS ABSTR INT A, V64, P3246
Owen-DeSchryver JS, 2008, FOCUS AUTISM DEV DIS, V23, P15, DOI 10.1177/1088357608314370
Pierce K., 1997, FOCUS AUTISM OTHER D, V12
PIERCE K, 1995, J APPL BEHAV ANAL, V28, P285, DOI 10.1901/jaba.1995.28-285
Rosenbaum P. L., 1988, CHILDRENS HLTH CARE, V17, P1, DOI [10.1207/s15326888chc1701_5, DOI 10.1207/S15326888CHC1701_5]
ROSENTHAL R, 1963, AM SCI, V51, P268
Rosenthal R., 1989, 97 ANN CONV AM PSYCH
Sabin E., 2006, AUTISM ACCEPTANCE BO
Sandieson R., 2002, INT J DISABIL DEV ED, V49, P243, DOI [10.1080/1034912022000007270, DOI 10.1080/1034912022000007270]
Scott J, 2000, STUDENTS AUTISM CHAR
SERBIN LA, 1986, CHILD DEV, V57, P1188, DOI 10.1111/j.1467-8624.1986.tb00447.x
Siperstein G. N., 1977, INSTRUMENTS ME UNPUB
Siperstein G. N., 1980, J VISUAL IMPAIRMENT, P132
Smith LA, 2001, CHILD CARE HLTH DEV, V27, P603, DOI 10.1046/j.1365-2214.2001.00236.x
Swaim KF, 2001, J AUTISM DEV DISORD, V31, P195, DOI 10.1023/A:1010703316365
Volkmar FR, 2003, LANCET, V362, P1133, DOI 10.1016/S0140-6736(03)14471-6
NR 54
TC 0
Z9 0
PU INT INST ADVANCED STUDIES PSYCHOTHERAPY & APPLIED MENTAL HEALTH
PI CLUJ
PA NO 37 , REPUBLICII STR, CLUJ-NAPOCA, CLUJ, 00000, ROMANIA
SN 1584-7101
J9 J COGN BEHAV PSYCHOT
JI J. Cogn. Behav. Psychother.
PD SEP
PY 2012
VL 12
IS 2
BP 139
EP 158
PG 20
WC Psychology, Clinical
SC Psychology
GA 044XF
UT WOS:000311657800002
ER
PT J
AU Bondy, A
AF Bondy, Andy
TI THE UNUSUAL SUSPECTS: MYTHS AND MISCONCEPTIONS ASSOCIATED WITH PECS
SO PSYCHOLOGICAL RECORD
LA English
DT Article
DE PECS; verbal behavior; communication training; AAC
ID EXCHANGE-COMMUNICATION-SYSTEM; SEVERE DEVELOPMENTAL-DISABILITIES; AUTISM
SPECTRUM DISORDERS; FUNCTIONAL COMMUNICATION; ALTERNATIVE COMMUNICATION;
SPEECH DEVELOPMENT; REQUESTING SKILLS; YOUNG-CHILDREN; BEHAVIOR;
ACQUISITION
AB The Picture Exchange Communication System (PECS) is an alternative/augmentative communication protocol designed to help children and adults with autism and related disabilities to engage in functional communication. The protocol was developed over a number of years and was based on Skinner's analysis of verbal behavior. Publications about the application and effectiveness of PECS have grown steadily. However, there also are many misconceptions about the protocol and its implementation. This paper reviews some of the research associated with PECS, describes several myths and misconceptions, and attempts to clarify many of the issues raised.
C1 [Bondy, Andy] Pyramid Educ Consultants Inc, Newark, DE USA.
RP Bondy, A (reprint author), PGMSC, 325 E Main St, Newark, DE 19711 USA.
EM abondy@pecs.com
CR Ali E, 2011, EDUC TRAIN AUTISM DE, V46, P425
Almeida Maria Amélia, 2005, Pro Fono, V17, P233, DOI 10.1590/S0104-56872005000200012
Anderson A. E., 2001, THESIS U CALIFORNIA
ANGERMEIER A., 2008, RES AUTISM SPECT DIS, V2, P430
Axelrod S., 2002, BEHAV ANAL TODAY, V2, P259
Barbera M. L., 2007, VERBAL BEHAV APPROAC
BARBERA M. L., 2009, WHAT ARE DIFFERENCES
Bock SJ, 2005, EDUC TRAIN DEV DISAB, V40, P264
BONDY A., 1988, ANN ASS BEH AN CONV
Bondy A, 2004, BEHAV ANALYST, V27, P247
BONDY A., 2011, PYRAMID APPROACH ED
Bondy A. S., 1994, FOCUS AUTISTIC BEHAV, V9, P1, DOI DOI 10.1177/108835769400900301
BONDY AS, 1993, BEHAV ANALYST, V16, P123
CARBONE CLINIC, SPEECH PROD ALT COMM
Carbone V. J., 2006, J SPEECH LANGUAGE PA, V1, P181
CATANIA A. C., 2002, EUROPEAN J BEHAV ANA, V3, P81
Chambers M, 2003, RES DEV DISABIL, V24, P265, DOI 10.1016/S0891-4222(03)00042-8
Charlop MH, 2008, J DEV PHYS DISABIL, V20, P509, DOI 10.1007/s10882-008-9112-x
Charlop-Christy MH, 2002, J APPL BEHAV ANAL, V35, P213, DOI 10.1901/jaba.2002.35-213
CONKLIN C., 2010, REM SPEC EDUC, V32, P155
Chaabane DBB, 2009, J APPL BEHAV ANAL, V42, P671, DOI 10.1901/jaba.2009.42-671
Dooley P., 2001, J POSIT BEHAV INTERV, V3, P57, DOI 10.1177/109830070100300108
DURAND VM, 1991, J APPL BEHAV ANAL, V24, P251, DOI 10.1901/jaba.1991.24-251
Fillipin M., 2010, AM J SPEECH-LANG PAT, V19, P178
FROST L., 2011, PERSPECTIVES AUGMENT, V20, P114
Frost L., 2002, PICTURE EXCHANGE COM, V2nd
FROST L., 1997, CTR OUTR SERV AUT CO
FROST L., 2006, J SPEECH LANGUAGE PA, V1, P103
Ganz JB, 2004, J AUTISM DEV DISORD, V34, P395, DOI 10.1023/B:JADD.0000037416.59095.d7
Greer R. D., 2008, VERBAL BEHAV ANAL IN
Hart SL, 2010, REM SPEC EDUC, V31, P476, DOI 10.1177/0741932509338354
Henderson L. M., 2008, AUTISM, V12, P573, DOI DOI 10.1177/1362361308096403
Howard JS, 2005, RES DEV DISABIL, V26, P359, DOI 10.1016/j.ridd.2004.09.005
Howlin P, 2007, J CHILD PSYCHOL PSYC, V48, P473, DOI 10.1111/j.1469-7610.2006.01707.x
Johnson JM, 2006, AUGMENT ALTERN COMM, V22, P85, DOI 10.1080/07434610500483588
JOHNSON KR, 1994, BEHAVIOR ANALYSIS IN EDUCATION, P173
Kates-McElrath K., 2006, BEHAV ANAL TODAY, V7, P242
Koegel LK, 2003, TOP LANG DISORD, V23, P134
Lancioni GE, 2007, RES DEV DISABIL, V28, P468, DOI 10.1016/j.ridd.2006.06.003
LAVALLEY A., 2010, ANN ASS BEH AN INT C
LAYTON T., 1995, TEACHING CHILDREN AU, P73
Leaf JB, 2010, J APPL BEHAV ANAL, V43, P215, DOI 10.1901/jaba.2010.43-215
Leaf R., 1999, WORK PROGR BEHAV MAN
LOVAAS OI, 1987, J CONSULT CLIN PSYCH, V55, P3, DOI 10.1037/0022-006X.55.1.3
Lovaas O. I., 1981, TEACHING DEV DISABLE
Lovaas O. I., 2003, TEACHING INDIVIDUALS
Lund S. K., 2007, J AUTISM DEV DISORD, V38, P719
Marckel JM, 2006, J APPL BEHAV ANAL, V39, P109, DOI 10.1901/jaba.2006.131-04
Maurice C., 1993, LET ME HEAR YOUR VOI
MAYER R., 2011, BEHAV ANAL LASTING C
McClannahan L. E., 1999, ACTIVITY SCHEDULES C
Michael J, 1985, Anal Verbal Behav, V3, P1
Mirenda P, 2003, LANG SPEECH HEAR SER, V34, P203, DOI 10.1044/0161-1461(2003/017)
NATIONAL AUTISM ASSOCIATION, AUS FACT SHEET
National Professional Development Center on Autism Spectrum Disorders, WHAT AR EV BAS PRACT
OKALIDOU A., 2007, FOCUS AUTISM OTHER D, V22, P23
Partington J. W., 2006, ASSESSMENT BASIC LAN
Potter B, 1997, Anal Verbal Behav, V14, P85
RAPOZA-HOULE S., 2010, ANN ASS BEH AN INT C
Rehfeldt R. A., 2009, DERIVED RELATIONAL R
Rehfeldt RA, 2005, J APPL BEHAV ANAL, V38, P101, DOI 10.1901/jaba.2005.106-03
Schlosser RW, 2008, AM J SPEECH-LANG PAT, V17, P212, DOI 10.1044/1058-0360(2008/021)
SCHREIBMAN L., 2008, ASS BEHAV ANAL NEWSL, V31, P40
Schwartz IS, 1998, TOP EARLY CHILD SPEC, V18, P144
Schwartz J. B., 2006, EBP BRIEFS, V1, P1
Skinner B. F., 1957, VERBAL BEHAV
SKINNER BF, 1966, SCIENCE, V153, P1205, DOI 10.1126/science.153.3741.1205
Skinner BF, 1937, J GEN PSYCHOL, V16, P272
SOCIETY FOR THE EXPERIMENTAL ANALYSIS OF BEHAVIOR, 2011, 25 MOST POP JAB ART
STONE WL, 1990, J AUTISM DEV DISORD, V20, P437, DOI 10.1007/BF02216051
Stoner JB, 2006, REM SPEC EDUC, V27, P154, DOI 10.1177/07419325060270030401
Sulzer-Azaroff B, 2009, FOCUS AUTISM DEV DIS, V24, P89, DOI 10.1177/1088357609332743
Sundberg M. L., 1998, TEACHING LANGUAGE CH
Sundberg M. L., 2008, VB MAPP VERBAL BEHAV
TERRACE HS, 1963, J EXP ANAL BEHAV, V6, P223, DOI 10.1901/jeab.1963.6-223
Tien KC, 2008, EDUC TRAIN DEV DISAB, V43, P61
Tincani M, 2006, EDUC TRAIN DEV DISAB, V41, P177
Tincani M., 2004, FOCUS AUTISM OTHER D, V19, P152, DOI DOI 10.1177/10883576040190030301
Tincani M, 2011, REM SPEC EDUC, V32, P458, DOI 10.1177/0741932510362494
TOUCHETTE PE, 1984, J APPL BEHAV ANAL, V17, P175, DOI 10.1901/jaba.1984.17-175
TRILLA K., 2008, VERBAL BEHAV
Vargas E A, 1984, Behav Anal, V7, P67
Wood AL, 2007, BEHAV MODIF, V31, P847, DOI 10.1177/0145445507302893
Yoder P, 2006, J CONSULT CLIN PSYCH, V74, P426, DOI 10.1037/0022-006X.74.3.426
Yoder P, 2006, J SPEECH LANG HEAR R, V49, P698, DOI 10.1044/1092-4388(2006/051)
Yoder PJ, 2010, J AUTISM DEV DISORD, V40, P629, DOI 10.1007/s10803-009-0897-y
Ziomek Megan M, 2008, Anal Verbal Behav, V24, P15
NR 87
TC 3
Z9 3
PU PSYCHOLOGICAL RECORD
PI CARBONDALE
PA SOUTHERN ILLINOIS UNIV, REHABILITATION INSTITUTE, CARBONDALE, IL
62901-4609 USA
SN 0033-2933
J9 PSYCHOL REC
JI Psychol. Rec.
PD FAL
PY 2012
VL 62
IS 4
BP 789
EP 816
PG 28
WC Psychology, Multidisciplinary
SC Psychology
GA 036CA
UT WOS:000311002800015
ER
PT J
AU De Andres-Garcia, S
Moya-Albiol, L
Gonzalez-Bono, E
AF De Andres-Garcia, S.
Moya-Albiol, L.
Gonzalez-Bono, E.
TI Salivary cortisol and immunoglobulin A: Responses to stress as
predictors of health complaints reported by caregivers of offspring with
autistic spectrum disorder
SO HORMONES AND BEHAVIOR
LA English
DT Article
DE Caregivers; Acute psychosocial stress; Autistic spectrum disorder;
Immunoglobulin A; Cortisol; Mood; Health complaints; Chronic stress
ID HIGH-FUNCTIONING AUTISM; PITUITARY-ADRENAL AXIS; NORMAL SEX-DIFFERENCES;
LOW SECRETION RATES; DEMENTIA PATIENTS; DEVELOPMENTAL-DISABILITIES;
PARENTAL CAREGIVERS; ANTIBODY-RESPONSE; ASPERGER-SYNDROME;
IMMUNE-RESPONSE
AB In the caregiving model of chronic stress, few studies have been conducted with young middle-aged samples and no data exists about acute stress response in this population. To extend knowledge in this issue, health complaints and psychological, endocrine, and immunological responses to stress have been assessed in a cross-sectional sample of 41 parents of offspring with autistic spectrum disorder (ASD) in comparison with 37 non-caregiver parents. Salivary cortisol and immunoglobulin A (IgA) levels were measured before, during, and after a mental psychosocial stressor, while mood and state anxiety were evaluated before and after the stress. Health complaints, personality traits, socio-economic status, and characteristics of the care recipient were assessed. Caregivers reported more health complaints showing buffered cortisol and IgA responses and greater increases in fatigue to acute stress than the controls. In terms of predictive power of health complaints, IgA levels, care status, and severity of the care recipient are especially relevant for caregivers. Results strongly suggest a dysregulation in the immune and hormonal stress-induced responses in middle-aged caregivers, with immune component and care characteristics as the main modulators of health complaints. A deficit in the adaptive capability of stress response is plausible in this population, emphasizing the need to consider family approaches when planning protocols for assistance to ASD patients. (C) 2012 Elsevier Inc. All rights reserved.
C1 [De Andres-Garcia, S.; Moya-Albiol, L.; Gonzalez-Bono, E.] Univ Valencia, Psychol Ctr, Dept Psychobiol, Valencia 46010, Spain.
RP Gonzalez-Bono, E (reprint author), Univ Valencia, Psychol Ctr, Dept Psychobiol, Avda Blasco Ibanez 21, Valencia 46010, Spain.
EM Esperanza.Gonzalez@uv.es
RI GONZALEZ-BONO, ESPERANZA/K-2953-2012; Moya-Albiol, Luis/C-6078-2011
FU Ministry of Science and Education of the Spanish Government
[PSI2008-04408/PSIC]; General Direction of Science Policy of the
Ministry of Education of the Valencian Regional Government
[ACOMP/2010/250, PROMETEO/2011/048]; University of Valencia Research
Service [UV-INV-AE11-41173]
FX This work was supported by the Ministry of Science and Education of the
Spanish Government (PSI2008-04408/PSIC), by the General Direction of
Science Policy of the Ministry of Education of the Valencian Regional
Government (ACOMP/2010/250 and PROMETEO/2011/048), and by the University
of Valencia Research Service (UV-INV-AE11-41173). The use of English was
revised by John Rawlins.
CR Abbeduto L, 2004, AM J MENT RETARD, V109, P237, DOI 10.1352/0895-8017(2004)109<237:PWACIM>2.0.CO;2
Bagley SL, 2011, PHYSIOL BEHAV, V104, P180, DOI 10.1016/j.physbeh.2011.03.004
Bailey DB, 2007, MENT RETARD DEV D R, V13, P321, DOI 10.1002/mrdd.20172
Barker ET, 2011, DEV PSYCHOL, V47, P551, DOI 10.1037/a0021268
Baron-Cohen S, 2001, J AUTISM DEV DISORD, V31, P5, DOI 10.1023/A:1005653411471
Baron-Cohen S, 2006, J AUTISM DEV DISORD, V36, P343, DOI 10.1007/s10803-006-0073-6
Baron-Cohen S, 2004, J AUTISM DEV DISORD, V34, P163, DOI 10.1023/B:JADD.0000022607.19833.00
Baron-Cohen S, 2003, PHILOS T ROY SOC B, V358, P361, DOI 10.1098/rstb.2002.1206
Bella GP, 2011, PSYCHONEUROENDOCRINO, V36, P834, DOI 10.1016/j.psyneuen.2010.11.005
Brosschot JF, 2005, PSYCHONEUROENDOCRINO, V30, P1043, DOI 10.1016/j.psyneuen.2005.04.008
Cacioppo JT, 1998, HEALTH PSYCHOL, V17, P182, DOI 10.1037/0278-6133.17.2.182
Cacioppo JT, 2000, ANN BEHAV MED, V22, P140, DOI 10.1007/BF02895778
Carrillo E, 2001, INT J PSYCHOPHYSIOL, V42, P253, DOI 10.1016/S0167-8760(01)00147-7
Chang HY, 2010, ARCH GERONTOL GERIAT, V50, P267, DOI 10.1016/j.archger.2009.04.006
Chrousos GP, 1998, ANN NY ACAD SCI, V851, P311, DOI 10.1111/j.1749-6632.1998.tb09006.x
Daire AP, 2002, GERONTOLOGIST, V42, P766
DAWES C, 1993, ANN NY ACAD SCI, V694, P265, DOI 10.1111/j.1749-6632.1993.tb18359.x
de Andrés García Sara, 2011, Psicothema, V23, P196
de Vugt ME, 2005, J NEUROPSYCH CLIN N, V17, P201, DOI 10.1176/appi.neuropsych.17.2.201
Dhabhar FS, 1997, BRAIN BEHAV IMMUN, V11, P286, DOI 10.1006/brbi.1997.0508
Dhabhar FS, 2009, NEUROIMMUNOMODULAT, V16, P300, DOI 10.1159/000216188
Dickerson SS, 2004, PSYCHOL BULL, V130, P355, DOI 10.1037/0033-2909.130.3.355
ENDICOTT J, 1976, ARCH GEN PSYCHIAT, V33, P766
Epel ES, 2010, BRAIN BEHAV IMMUN, V24, P531, DOI 10.1016/j.bbi.2009.11.018
Gallagher S, 2009, BRAIN BEHAV IMMUN, V23, P338, DOI 10.1016/j.bbi.2008.05.006
Gallagher S, 2008, BRAIN BEHAV IMMUN, V22, P565, DOI 10.1016/j.bbi.2007.11.007
Gennaro S, 1997, BRAIN BEHAV IMMUN, V11, P201, DOI 10.1006/brbi.1997.0502
Gleeson M, 1999, IMMUNOL CELL BIOL, V77, P351, DOI 10.1046/j.1440-1711.1999.00839.x
GOLDBERG DP, 1979, PSYCHOL MED, V9, P139
Gonzalez-Bono E, 2011, ANXIETY STRESS COPIN, V24, P107, DOI 10.1080/10615806.2010.481792
Harmell AL, 2011, CURR PSYCHIAT REP, V13, P219, DOI 10.1007/s11920-011-0187-1
Kim Y, 2007, PSYCHO-ONCOL, V16, P714, DOI 10.1002/pon.1110
Kirschbaum C, 1999, PSYCHOSOM MED, V61, P154
KIRSCHBAUM C, 1993, NEUROPSYCHOBIOLOGY, V28, P76, DOI 10.1159/000119004
Kluger J., 1992, J CLIN IMMUNOL, V12, P45
Lach LM, 2009, DISABIL REHABIL, V31, P741, DOI 10.1080/08916930802354948
Lovell B, 2012, PSYCHONEUROENDOCRINO, V37, P534, DOI 10.1016/j.psyneuen.2011.08.003
Lovell B, 2012, RES DEV DISABIL, V33, P682, DOI 10.1016/j.ridd.2011.11.014
Lovell B, 2011, NEUROSCI BIOBEHAV R, V35, P1342, DOI 10.1016/j.neubiorev.2011.02.007
MAHONEY F I, 1965, Md State Med J, V14, P61
Marin TJ, 2009, PSYCHOSOM MED, V71, P378, DOI 10.1097/PSY.0b013e318199dbc3
McEwen BS, 2003, METABOLISM, V52, P10, DOI 10.1053/S0026-0495(03)00295-6
McGirr A, 2010, J PSYCHIATR NEUROSCI, V35, P399, DOI 10.1503/jpn.090121
McNair DM, 1992, POMS MANUAL PROFILE
Neri M, 2007, ARCH GERONTOL GERIAT, V44, P289, DOI 10.1016/j.archger.2007.01.038
Orsmond GI, 2007, J INTELL DISABIL RES, V51, P682, DOI 10.1111/j.1365-2788.2007.00954.x
Pariante CM, 1997, PSYCHOTHER PSYCHOSOM, V66, P199
Phillips AC, 2006, BRAIN BEHAV IMMUN, V20, P191, DOI 10.1016/j.bbi.2005.06.006
Pinquart M, 2003, PSYCHOL AGING, V18, P250, DOI 10.1037/0882-7974.18.2.250
Pruessner JC, 2003, PSYCHONEUROENDOCRINO, V28, P916, DOI 10.1016/S0306-4530(02)00108-7
Pruessner JC, 1997, LIFE SCI, V61, P2539, DOI 10.1016/S0024-3205(97)01008-4
Rabinowitz YG, 2011, AM J ALZHEIMERS DIS, V26, P310, DOI 10.1177/1533317511410557
Raina P, 2005, PEDIATRICS, V115, pE626, DOI 10.1542/peds.2004-1689
Rohleder N, 2009, J CLIN ONCOL, V27, P2909, DOI 10.1200/JCO.2008.18.7435
Salvador A, 2003, PSYCHONEUROENDOCRINO, V28, P364, DOI 10.1016/S0306-4530(02)00028-8
Sandin B., 1995, ESCALA SINTOMAS SOMA
Sansoni Julita, 2004, Int J Nurs Pract, V10, P93, DOI 10.1111/j.1440-172X.2003.00461.x
Segerstrom SC, 2008, BRAIN BEHAV IMMUN, V22, P744, DOI 10.1016/j.bbi.2007.11.004
Seltzer MM, 2009, J HEALTH SOC BEHAV, V50, P1
Seltzer MM, 2010, J AUTISM DEV DISORD, V40, P457, DOI 10.1007/s10803-009-0887-0
Singer GHS, 2006, AM J MENT RETARD, V111, P155, DOI 10.1352/0895-8017(2006)111[155:MOCSOD]2.0.CO;2
Smith LE, 2010, J AUTISM DEV DISORD, V40, P167, DOI 10.1007/s10803-009-0844-y
Spielberger C., 1983, ADV PERSONALITY ASSE, V2, P159
Spielberger C., 1970, MANUAL STATE TRAIT A
Tabak N, 1997, Int J Nurs Pract, V3, P84, DOI 10.1111/j.1440-172X.1997.tb00079.x
Vedhara K, 2002, J PSYCHOSOM RES, V53, P1153, DOI 10.1016/S0022-3999(02)00343-4
Vedhara K, 1999, LANCET, V353, P627, DOI 10.1016/S0140-6736(98)06098-X
Vitaliano PP, 2003, PSYCHOL BULL, V129, P946, DOI 10.1037/0033-2909.129.6.946
Woodgate RL, 2008, QUAL HEALTH RES, V18, P1075, DOI 10.1177/1049732308320112
ZARIT SH, 1980, GERONTOLOGIST, V20, P649
NR 70
TC 15
Z9 15
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0018-506X
J9 HORM BEHAV
JI Horm. Behav.
PD SEP
PY 2012
VL 62
IS 4
BP 464
EP 474
DI 10.1016/j.yhbeh.2012.08.003
PG 11
WC Behavioral Sciences; Endocrinology & Metabolism
SC Behavioral Sciences; Endocrinology & Metabolism
GA 031PJ
UT WOS:000310654100015
PM 22981424
ER
PT J
AU Guo, X
Tu, WJ
Shi, XD
AF Guo, Xin
Tu, Wen-Jun
Shi, Xiao-Dong
TI Tuberous Sclerosis Complex in Autism
SO IRANIAN JOURNAL OF PEDIATRICS
LA English
DT Article
DE Tuberous Sclerosis Complex; Autism; Autistic Disorder; Neurocutaneous
Syndromes
ID MEDICAL DISORDERS; CHILDREN
AB Objective: To study the prevalence rate of tuberous sclerosis complex in autistic disorder.
Methods: We studied one cohort of children followed up since 2005 until 2009, with autistic disorder, to determine the incidence of tuberous sclerosis complex. We established an autistic disorder registry in 2005 at China Rehabilitation Research Center. During the 4-year period (2005-2009), we collected a database of 429 children (390 boys and 39 girls; male to female ratio 10:1) with autistic disorder and pervasive developmental disorders. We routinely examined all children with autistic disorder for any features of tuberous sclerosis complex by looking for neurocutaneous markers such as depigmented spots. In those with infantile spasm or epilepsy, the clinical features of tuberous sclerosis complex were monitored regularly during follow-up.
Findings: Of these, five had tuberous sclerosis complex. Thus, the prevalence rate of tuberous sclerosis complex in autistic disorder is 1.17%. All of these children were mentally retarded with moderate to severe grades. Their IQ or developmental quotient was less than 70.
Conclusion: The prevalence rate of tuberous sclerosis complex in autistic disorder was 1.17% in our region; autism spectrum disorder is a condition that might be associated with development of tuberous sclerosis complex
C1 [Guo, Xin] Harbin Med Univ, Dept Clin Lab, Affiliated Hosp 1, Harbin, Peoples R China.
[Tu, Wen-Jun; Shi, Xiao-Dong] China Rehabil Res Ctr, Dept Clin Lab, Beijing, Peoples R China.
RP Guo, X (reprint author), 23 You Zheng St, Harbin 150001, Heilongjiang Pr, Peoples R China.
EM zsf0508@163.com
CR American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th
Chora M, 2011, J PAEDIATR CHILD H, V47, P711
Curatolo P, 2004, EUR J PAEDIATR NEURO, V8, P327, DOI 10.1016/j.ejpn.2004.08.005
Daniels AM, 2012, J AUTISM DEV DISORD, V42, P257, DOI 10.1007/s10803-011-1236-7
Fombonne E, 1997, J AM ACAD CHILD PSY, V36, P1561, DOI 10.1016/S0890-8567(09)66566-7
GILLBERG IC, 1994, DEV MED CHILD NEUROL, V36, P50
HUNT A, 1993, J AUTISM DEV DISORD, V23, P323, DOI 10.1007/BF01046223
Kielinen M, 2004, AUTISM, V8, P49, DOI 10.1177/1362361304040638
LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
Muhle R., 2004, PEDIATRICS, V113, P472
Riquet A, 2010, ARCH PEDIATRIE, V17, P1338, DOI 10.1016/j.arcped.2010.06.019
Roach ES, 1999, J CHILD NEUROL, V14, P401, DOI 10.1177/088307389901400610
Smalley SL, 1998, J AUTISM DEV DISORD, V28, P407, DOI 10.1023/A:1026052421693
Wiznitzer M, 2004, J CHILD NEUROL, V19, P675
Wong V, 2006, J CHILD NEUROL, V21, P199, DOI 10.2310/7010.2006.00046
NR 15
TC 0
Z9 0
PU IRANIAN SCIENTIFIC SOCIETY MEDICAL ENTOMOLOGY
PI TEHRAN
PA SCHOOL PUBLIC HEALTH & INST HEALTH RESEARCH, TEHRAN UNIV MEDICAL
SCIENCES, P O BOX 6446-14155, TEHRAN, 00000, IRAN
SN 2008-2142
J9 IRAN J PEDIATR
JI Iran. J. Pediatr.
PD SEP
PY 2012
VL 22
IS 3
BP 408
EP 411
PG 4
WC Pediatrics
SC Pediatrics
GA 028GN
UT WOS:000310410900022
PM 23400643
ER
PT J
AU Shachar, BZ
Lyell, DJ
AF Shachar, Bat Zion
Lyell, Deirdre J.
TI Interpregnancy Interval and Obstetrical Complications
SO OBSTETRICAL & GYNECOLOGICAL SURVEY
LA English
DT Article
ID LOW-BIRTH-WEIGHT; CLOSELY SPACED PREGNANCIES; PREVIOUS CESAREAN
DELIVERY; NEURAL-TUBE DEFECTS; PERINATAL OUTCOMES; UTERINE RUPTURE;
PRETERM DELIVERY; INTERDELIVERY INTERVAL; MATERNAL MORBIDITY; NEONATAL
DEATH
AB Obstetricians are often presented with questions regarding the optimal interpregnancy interval (IPI). Short IPI has been associated with adverse perinatal and maternal outcomes, ranging from preterm birth and low birth weight to neonatal and maternal morbidity and mortality. Long IPI has in turn been associated with increased risk for preeclampsia and labor dystocia. In this review, we discuss the data regarding these associations along with recent studies revealing associations of short IPI with birth defects, schizophrenia, and autism. The optimal IPI may vary for different subgroups. We discuss the consequences of short IPI in women with a prior cesarean section, in particular the increased risk for uterine rupture and the considerations regarding a trial of labor in this subgroup. We review studies examining the interaction between short IPI and advanced maternal age and discuss the risk-benefit assessment for these women. Finally, we turn our attention to women after a stillbirth or an abortion, who often desire to conceive again with minimal delay. We discuss studies speaking in favor of a shorter IPI in this group. The accumulated data allow for the reevaluation of current IPI recommendations and management guidelines for women in general and among subpopulations with special circumstances. In particular, we suggest lowering the current minimal IPI recommendation to only 18 months (vs 24 months according to the latest World Health Organization recommendations), with even shorter recommended minimal IPI for women of advanced age and those who conceive after a spontaneous or induced abortion.
C1 [Shachar, Bat Zion; Lyell, Deirdre J.] Stanford Univ, Sch Med, Dept Obstet & Gynecol, Stanford, CA 94305 USA.
[Shachar, Bat Zion] Stanford Univ, Sch Med, Dept Pediat Neonatal & Dev Med, Stanford, CA 94305 USA.
[Lyell, Deirdre J.] Stanford Univ, Lucile Packard Childrens Hosp, Stanford, CA 94305 USA.
RP Shachar, BZ (reprint author), Stanford Univ, Sch Med, Dept Obstet & Gynecol, Stanford, CA 94305 USA.
EM bshachar@stanford.edu
CR ACOG, 2010, OBSTET GYNECOL, V116, P450
[Anonymous], 2008, FERTIL STERIL, V90, P486
[Anonymous], 2005, REP WHO TECHN CONS B
Arafa MA, 2004, PAEDIATR PERINAT EP, V18, P248, DOI 10.1111/j.1365-3016.2004.00564.x
Auger Nathalie, 2008, BMC Pregnancy Childbirth, V8, P7, DOI 10.1186/1471-2393-8-7
Bakewell JM, 1997, PAEDIATR PERINAT EP, V11, P119, DOI 10.1046/j.1365-3016.11.s1.4.x
Basso O, 2003, HUM REPROD, V18, P2478, DOI 10.1093/humrep/deg444
Basso O, 2001, EPIDEMIOLOGY, V12, P624, DOI 10.1097/00001648-200111000-00008
Basso O, 1998, AM J OBSTET GYNECOL, V178, P259, DOI 10.1016/S0002-9378(98)80010-0
Bhattacharya Sohinee, 2011, Womens Health (Lond Engl), V7, P139, DOI 10.2217/whe.11.2
Brent RL, 2004, PEDIATRICS, V113, P957
Bujold E, 2010, OBSTET GYNECOL, V115, P1003, DOI 10.1097/AOG.0b013e3181d992fb
Cheslack-Postava K, 2011, PEDIATRICS, V127, P246, DOI 10.1542/peds.2010-2371
Cheung VYT, 2004, J ULTRAS MED, V23, P1441
Cleary-Goldman J, 2005, OBSTET GYNECOL, V105, P983, DOI 10.1097/01.AOG.0000158118.75532.51
Conde-Agudelo A, 2006, JAMA-J AM MED ASSOC, V295, P1809, DOI 10.1001/jama.295.15.1809
Conde-Agudelo A, 2005, INT J GYNECOL OBSTET, V89, pS34, DOI 10.1016/j.ijgo.2004.08.003
Conde-Agudelo A, 2000, BRIT MED J, V321, P1255, DOI 10.1136/bmj.321.7271.1255
Conde-Agudelo A, 2005, OBSTET GYNECOL, V106, P359, DOI 10.1097/01.AOG.0000171118.79529.a3
Conde-Agudelo A, 2007, AM J OBSTET GYNECOL, V196, P297, DOI 10.1016/j.ajog.2006.05.055
CZEIZEL AE, 1992, NEW ENGL J MED, V327, P1832, DOI 10.1056/NEJM199212243272602
DaVanzo J, 2008, POP STUD-J DEMOG, V62, P131, DOI 10.1080/00324720802022089
DaVanzo J, 2007, BJOG-INT J OBSTET GY, V114, P1079, DOI 10.1111/j.1471-0528.2007.01338,x
de Weger FJ, 2011, AM J OBSTET GYNECOL, V204, p421e1
DeFranco EA, 2007, AM J OBSTET GYNECOL, V197
Dewey KG, 2007, MATERN CHILD NUTR, V3, P151, DOI 10.1111/j.1740-8709.2007.00092.x
Ekwo EE, 1998, INT J EPIDEMIOL, V27, P68, DOI 10.1093/ije/27.1.68
ERICKSON JD, 1978, J EPIDEMIOL COMMUN H, V32, P124, DOI 10.1136/jech.32.2.124
ERICKSON JD, 1979, LANCET, V1, P52
Fortney JA, 1998, STUD FAMILY PLANN, V29, P436, DOI 10.2307/172258
Fuentes-Afflick E, 2000, OBSTET GYNECOL, V95, P383, DOI 10.1016/S0029-7844(99)00583-9
Getahun D, 2010, AM J OBSTET GYNECOL, V202, p570e1
Getahun D, 2006, OBSTET GYNECOL, V107, P771, DOI 10.1097/01.AOG.0000206182.63788.80
Ghidini A, 2005, ACTA OBSTET GYN SCAN, V84, P547, DOI 10.1111/j.0001-6349.2005.00694.x
Gold KJ, 2010, AM J OBSTET GYNECOL, V202
Goldenberg RL, 2008, LANCET, V371, P75, DOI 10.1016/S0140-6736(08)60074-4
Grisaru-Granovsky S, 2009, CONTRACEPTION, V80, P512, DOI 10.1016/j.contraception.2009.06.006
Gunawardana L, 2011, BRIT J PSYCHIAT, V199, P338, DOI 10.1192/bjp.bp.111.092916
Himes KP, 2008, OBSTET GYNECOL, V112, P121, DOI 10.1097/AOG.0b013e318179f024
Huang WH, 2002, OBSTET GYNECOL, V99, P41, DOI 10.1016/S0029-7844(01)01652-0
Khan KS, 1998, ACTA OBSTET GYN SCAN, V77, P395, DOI 10.1034/j.1600-0412.1998.770407.x
Khoshnood B, 1998, AM J EPIDEMIOL, V148, P798
King JC, 2003, J NUTR, V133, p1732S
Klebanoff MA, 1999, NEW ENGL J MED, V340, P643, DOI 10.1056/NEJM199902253400809
KLEBANOFF MA, 1988, AM J PUBLIC HEALTH, V78, P667, DOI 10.2105/AJPH.78.6.667
Kwon S, 2012, J PERINATOL, V32, P45, DOI 10.1038/jp.2011.49
Landon MB, 2010, SEMIN PERINATOL, V34, P267, DOI 10.1053/j.semperi.2010.03.005
Liu K, 2011, J OBSTET GYNAECOL CA, V33, P1165
Love ER, 2010, BRIT MED J, V341, DOI 10.1136/bmj.c3967
Luke B, 2007, FERTIL STERIL, V88, P283, DOI 10.1016/j.fertnstert.2006.11.008
Mikolajczyk RT, 2008, AM J EPIDEMIOL, V168, P422, DOI 10.1093/aje/kwn115
MILLER JE, 1991, FAM PLANN PERSPECT, V23, P62, DOI 10.2307/2135451
Mostello D, 2002, AM J OBSTET GYNECOL, V187, P425, DOI 10.1067/mob.2002.123608
Nabukera SK, 2008, J OBSTET GYNAECOL RE, V34, P941, DOI 10.1111/j.1447-0756.2008.00808.x
Orji E O, 2004, East Afr Med J, V81, P388
Razzaque A, 2005, INT J GYNECOL OBSTET, V89, pS41, DOI 10.1016/j.ijgo.2005.01.003
Reddy UM, 2007, OBSTET GYNECOL, V110, P1151, DOI 10.1097/01.AOG.0000287616.71602.d0
Rochelson B, 2005, J MATERN-FETAL NEO M, V18, P339, DOI 10.1080/14767050500275911
Rodrigues T, 2008, EUR J OBSTET GYN R B, V136, P184, DOI 10.1016/j.ejogrb.2007.03.014
Ronsmans C, 1998, STUD FAMILY PLANN, V29, P282, DOI 10.2307/172274
Rutstein SO, 2005, INT J GYNECOL OBSTET, V89, pS7, DOI 10.1016/j.ijgo.2004.11.012
Shipp TD, 2001, OBSTET GYNECOL, V97, P175, DOI 10.1016/S0029-7844(00)01129-7
Sholapurkar SL, 2010, J OBSTET GYNAECOL, V30, P107, DOI 10.3109/01443610903470288
Shults RA, 1999, EPIDEMIOLOGY, V10, P250, DOI 10.1097/00001648-199905000-00010
Singh K, 1998, EUR J CLIN NUTR, V52, P65, DOI 10.1038/sj.ejcn.1600517
Skjaerven R, 2002, NEW ENGL J MED, V346, P33, DOI 10.1056/NEJMoa011379
Smith GCS, 2003, BRIT MED J, V327, P313, DOI 10.1136/bmj.327.7410.313
Smits L, 2004, SCHIZOPHR RES, V70, P49, DOI 10.1016/j.schres.2003.10.002
Smits LJM, 2001, LANCET, V358, P2074, DOI 10.1016/S0140-6736(01)07105-7
Stamilio DM, 2007, OBSTET GYNECOL, V110, P1075, DOI 10.1097/01.AOG.0000286759.49895.46
St Clair D, 2005, JAMA-J AM MED ASSOC, V294, P557, DOI 10.1001/jama.294.5.557
Stephansson O, 2003, OBSTET GYNECOL, V102, P101, DOI 10.1016/S0029-7844(03)00366-1
Trogstad LIS, 2001, INT J EPIDEMIOL, V30, P1317, DOI 10.1093/ije/30.6.1317
WALD N, 1991, LANCET, V338, P131
WINKVIST A, 1992, AM J PUBLIC HEALTH, V82, P691, DOI 10.2105/AJPH.82.5.691
Zhu BP, 2001, AM J OBSTET GYNECOL, V185, P1403, DOI 10.1067/mob.2001.118307
Zhu BP, 2006, AM J OBSTET GYNECOL, V195, P121, DOI 10.1016/j.ajog.2005.12.016
Zhu Bao-Ping, 2003, Matern Child Health J, V7, P169, DOI 10.1023/A:1025184304391
Zhu BP, 2005, INT J GYNECOL OBSTET, V89, pS25, DOI 10.1016/j.ijgo.2004.08.002
Zhu BP, 1999, NEW ENGL J MED, V340, P589, DOI 10.1056/NEJM199902253400801
NR 80
TC 10
Z9 10
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0029-7828
J9 OBSTET GYNECOL SURV
JI Obstet. Gynecol. Surv.
PD SEP
PY 2012
VL 67
IS 9
BP 584
EP 596
DI 10.1097/OGX.0b013e31826b2c3e
PG 13
WC Obstetrics & Gynecology
SC Obstetrics & Gynecology
GA 030JZ
UT WOS:000310568300018
PM 22990461
ER
PT J
AU Dixit, A
Patel, C
Harrison, R
Jarvis, J
Hulton, S
Smith, N
Yates, K
Silcock, L
McMullan, DJ
Suri, M
AF Dixit, Abhijit
Patel, Chirag
Harrison, Rachel
Jarvis, Joanna
Hulton, Sally
Smith, Nigel
Yates, Katherine
Silcock, Lee
McMullan, Dominic J.
Suri, Mohnish
TI 17q12 Microdeletion Syndrome: Three Patients Illustrating the Phenotypic
Spectrum
SO AMERICAN JOURNAL OF MEDICAL GENETICS PART A
LA English
DT Article
DE renal cysts and diabetes syndrome (RCAD); cystic kidney disease;
maturity onset diabetes of the young type 5(MODY 5); blepharophimosis;
blocked nasolacrimal duct; hypospadias; laryngomalacia; transient
hypercalcemia; paucity of intrahepatic bile ducts; atypical Alagille
syndrome
ID GENOMIC REARRANGEMENTS; HYPERECHOGENIC KIDNEYS; CLINICAL SPECTRUM;
CHROMOSOME 17Q12; TCF2 GENE; YOUNG; DELETION; HNF-1-BETA; ANOMALIES;
AUTISM
AB Deletions of 17q12 are associated with renal cysts and maturity onset diabetes of the young, and have also been identified in women with reproductive tract anomalies due to Mullerian aplasia. Although initially identified in patients with normal cognitive ability, some patients with this recurrent microdeletion syndrome have learning problems. We identified a 17q12 microdeletion in three patients with renal cystic disease by array comparative genomic hybridization and the phenotypic spectrum of the 17q12 microdeletion syndrome is illustrated by the description of these patients. Of two patients who are old enough to be assessed, one has significant speech delay, autism spectrum disorder, and mild learning difficulty, while the other patient has only mild speech delay. This highlights the variability of cognitive involvement in this condition. The third patient presented with Alagille syndrome-like features in the neonatal period. All three patients had transient hypercalcemia in the neonatal period, a finding that has not previously been described in this condition. Moreover, two patients have mild or no dysmorphism, while one displays striking facial dysmorphism in addition to minor congenital anomalies. We suggest that while patients with 17q12 microdeletion syndrome can present with type 2 diabetes or renal cysts without any dysmorphic features, a subgroup may have dysmorphic features or present with neonatal cholestasis. Transient neonatal hypercalcemia may be a feature of this microdeletion syndrome. (C) 2012 Wiley Periodicals, Inc.
C1 [Dixit, Abhijit; Harrison, Rachel; Suri, Mohnish] City Hosp Nottingham, Dept Clin Genet, Nottingham NG5 1PB, England.
[Patel, Chirag; Jarvis, Joanna] Birmingham Womens Hosp, W Midlands Reg Genet Serv, Birmingham, W Midlands, England.
[Hulton, Sally] Birmingham Childrens Hosp, Dept Paediat Nephrol, Birmingham, W Midlands, England.
[Smith, Nigel; Yates, Katherine] City Hosp Nottingham, Dept Cytogenet, Nottingham NG5 1PB, England.
[Silcock, Lee; McMullan, Dominic J.] Birmingham Womens Hosp, Dept Mol Cytogenet, Birmingham, W Midlands, England.
RP Suri, M (reprint author), City Hosp Nottingham, Dept Clin Genet, Hucknall Rd, Nottingham NG5 1PB, England.
EM mohnish.suri@nuh.nhs.uk
CR Beckers D, 2007, J PEDIATR-US, V150, P313, DOI 10.1016/j.jpeds.2006.12.006
Bellanne-Chantelot C, 2005, DIABETES, V54, P3126, DOI 10.2337/diabetes.54.11.3126
Bernardini L, 2009, ORPHANET J RARE DIS, V4, DOI 10.1186/1750-1172-4-25
Chen YZ, 2010, CHINESE MED J-PEKING, V123, P3326, DOI 10.3760/cma.j.issn.0366-6999.2010.22.029
Coffinier C, 2002, DEVELOPMENT, V129, P1829
Decramer S, 2007, J AM SOC NEPHROL, V18, P923, DOI 10.1681/ASN.2006091057
Devriendt K, 1996, EUR J PEDIATR, V155, P87
Elia J, 2010, MOL PSYCHIATR, V15, P637, DOI 10.1038/mp.2009.57
Kitanaka S, 2004, J CLIN ENDOCR METAB, V89, P1369, DOI 10.1210/jc.2003-031308
Loirat C, 2010, NEPHROL DIAL TRANSPL, V25, P3430, DOI 10.1093/ndt/gfq380
Mefford HC, 2007, AM J HUM GENET, V81, P1057, DOI 10.1086/522591
Moreno-De-Luca D, 2010, AM J HUM GENET, V87, P618, DOI 10.1016/j.ajhg.2010.10.004
Nagamani SCS, 2010, EUR J HUM GENET, V18, P278, DOI 10.1038/ejhg.2009.174
Nik-Zainal S, 2011, J MED GENET, V48, P197, DOI 10.1136/jmg.2010.082412
Raile K, 2009, J CLIN ENDOCR METAB, V94, P2658, DOI 10.1210/jc.2008-2189
Ulinski T, 2006, J AM SOC NEPHROL, V17, P497, DOI 10.1681/ASN.2005101040
NR 16
TC 6
Z9 6
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1552-4825
J9 AM J MED GENET A
JI Am. J. Med. Genet. A
PD SEP
PY 2012
VL 158A
IS 9
BP 2317
EP 2321
DI 10.1002/ajmg.a.35520
PG 5
WC Genetics & Heredity
SC Genetics & Heredity
GA 023WU
UT WOS:000310068700035
PM 22887843
ER
PT J
AU Taleb, MO
AF Taleb, Mahmoud Ould
TI Autism and work with the mothers' of autistic children. Therapeutic
application in Alger, from 2005 to 2010
SO ANNALES MEDICO-PSYCHOLOGIQUES
LA French
DT Article
DE Algeria; Autism; Exchange and development therapy; Mothers as
"co-therapists"; Schopler's TEACCH program
ID SPECTRUM DISORDERS; INTERVENTIONS
AB In Algeria, child psychiatry is an emerging area of medical specialization which is very late in becoming part of the training for professionals and the provision of services. Due to this, the quality of the treatment of serious mental disorders for children and adolescents is insufficient, diverse, and sometimes non-existant. Currently autism is the major reason for consultation and treatment; the diagnosis is often late and comes when the child already has a significant developmental lag and cannot be enrolled in school - often the reason for the referral. The existing resources in our area are as follows: three units with part-time hospitalization in the capital and its suburbs, 40 child psychiatrists trained during the last two years in collaboration with the WHO, about ten outpatients clinics covering an extended territory with significant socio-demographic and health differences. Only from 18 years of age does the authorities in Algeria recognize autism (in fact as a mental retardation) with a minimal monthly family allowance to parents often at a loss or isolated when faced with an offer of assistance that is limited or difficult to access.
Objectives. - After having reviewed our sources for this work with the parents concerning autism, we then describe its organization, sequence of events, the difficulties encountered, and discuss propositions for further improvements.
Population and method. - In this context, the choice and application of a therapeutic method for autistic children needs to take into account the many constraints in terms of infrastructure and human resources. Due to its simplicity and effectiveness, we have, for both theoretical and practical purposes, for the past decade, considered that it was a good strategy to associate the exchange and development therapy with the Schopler's TEACCH program for those children receiving treatment in our daytime hospital service. It also met the professional qualification of our collaborators - most of them psychologists, speech therapists and care assistants. Another reason is that it is indispensable that the mothers of autistic children are involved in the treatment in order to obtain significant gains (Bartoov et al., 2002 [15] and Bartoov et al., 2001 1161).
Results. - This therapeutic application was implemented during 2005-2010 for a hundred autistic children and their mothers: 80 of them in daytime medical institution and 20 as outpatients with the same technical support. The mothers as "co-therapists" received a two-hour per month training (from September to June) during three years according to the rules and principles of the teaching activities for autistic children and "the educational strategies of autism" for parental practice, both coming from the TEACCH program (Li et al., 2006 [19] and Velez de la Calle et al., 2008 [20]).
Conclusion. - This involvement, while less than desirable, is proportional to our resources and nevertheless sufficiently promising and structuring to engage care dynamics and show beneficial effects in cognitive, affective and behavioral fields of the autistic child. After having reviewed our sources for this. work with the parents concerning autism, we then describe its organization, sequence of events, the difficulties encountered, and discuss propositions for further improvements. We then carefully examine the difficulties encountered, the means we have in order to make some progress, and we discuss how to evaluate the results, in the context of an experiment which is only beginning in this field in a developping nation. Last, but not least, we also took into consideration the "non-cooperative" mothers in order to adapt our therapy to their personal needs and to elaborate different objectives as far as they are concerned. (C) 2012 Elsevier Masson SAS. All rights reserved.
C1 Clin Garidi II Kouba, Serv Pedopsychiat, Algiers, Algeria.
RP Taleb, MO (reprint author), Clin Garidi II Kouba, Serv Pedopsychiat, Algiers, Algeria.
EM m.ould-taleb@gmx.com
CR ADRIEN JL, 1992, J AUTISM DEV DISORD, V22, P375, DOI 10.1007/BF01048241
Aussilloux C, 1998, Sante Ment Que, V23, P19
Baron-Cohen S, 2000, J ROY SOC MED, V93, P521
Barthelemy C, 1995, AUTISME ENFANT THERA
Dawson M, 2010, LANCET, V375, P722, DOI 10.1016/S0140-6736(10)60299-1
Bhutta Z, 2011, LANCET, V377, P969, DOI 10.1016/S0140-6736(11)60169-4
Green J, 2010, LANCET, V375, P2152, DOI 10.1016/S0140-6736(10)60587-9
Hartley S, 2009, LANCET, V374, P1803, DOI 10.1016/S0140-6736(09)62036-5
Jourdan R, 1993, ENFANTS AUTISTES COM
Lelord G, 1991, AUTISME ENFANT
Lelord G, 1978, CONCOURS MED, V100, P4659
Lenoir P, 2009, ENCEPHALE, V35, P36, DOI 10.1016/j.encep.2007.12.011
Levy SE, 2009, LANCET, V374, P1623
Lovaas I. O., 1973, J APPL BEHAV ANAL, V6, P131
Myers SM, 2009, PEDIATR ANN, V38, P42
National Research Council, 2001, ED CHILDR AUT
Osborne LA, 2008, J AUTISM DEV DISORD, V38, P1092, DOI 10.1007/s10803-007-0497-7
Ould Taleb M, 2010, REV NEUROPSYCHIATR E, V58, P159
Ould Taleb M, 2006, REV NEUROPSYCHIATR E, V54, P248
Parr J, 2007, BMJ CLIN EVID, V12, P322
Rogers SJ, 2008, J CLIN CHILD ADOLESC, V37, P8, DOI 10.1080/15374410701817808
Schopler E, 1993, ACTIVITES ENSEIGNEME
Schopler E, 1998, STRATEGIES ED AUTISM
Seida JK, 2009, DEV MED CHILD NEUROL, V51, P95, DOI 10.1111/j.1469-8749.2008.03211.x
Spence SJ, 2010, LANCET, V375, P2124, DOI 10.1016/S0140-6736(10)60757-X
Tyrer P, 2010, LANCET, V376, P322, DOI 10.1016/S0140-6736(10)61172-5
Wing L, 1980, AUTISTIC CHILDREN GU
NR 27
TC 0
Z9 0
PU MASSON EDITEUR
PI MOULINEAUX CEDEX 9
PA 21 STREET CAMILLE DESMOULINS, ISSY, 92789 MOULINEAUX CEDEX 9, FRANCE
SN 0003-4487
J9 ANN MED-PSYCHOL
JI Ann. Med.-Psychol.
PD SEP
PY 2012
VL 170
IS 7
BP 449
EP 455
DI 10.1016/j.amp.2012.05.018
PG 7
WC Pharmacology & Pharmacy; Psychiatry; Psychology; Psychology,
Multidisciplinary
SC Pharmacology & Pharmacy; Psychiatry; Psychology
GA 025KE
UT WOS:000310187000001
ER
PT J
AU Goussot, T
Auxiette, C
Chambres, P
AF Goussot, T.
Auxiette, C.
Chambres, P.
TI Educational interventions for children with autism only succeed when
appropriate parents interventions also succeed
SO ANNALES MEDICO-PSYCHOLOGIQUES
LA French
DT Article
DE Stress; Anxiety; Depression; Family care; Autism
ID BEHAVIORAL-ADJUSTMENT; ASPERGER-SYNDROME; SOCIAL SUPPORT; SIBLINGS;
DIAGNOSIS; STRESS; FAMILY; SCALE; DEPRESSION; COMPETENCE
AB The international literature on autism reports numerous findings consistent with the proposal that educational interventions for children with autism should begin as early as possible. Unfortunately, this proposal is not also accompanied by equal attention to parents who must face the problem of successfully raising their autistic child. The aim of the present article is to review a number of studies that have examined the relationship between family well-being and the efficacy of educational interventions for autistic children. Difficulties and distress encountered by parents as well as scales for evaluating stress level, anxiety or depression are described. Finally, consistent with the observation that educational interventions for children with autism only succeed when appropriate parents interventions also succeed, some suggestions are made to help parents cope with their unusual and difficult situation. (C) 2011 Elsevier Masson SAS. All rights reserved.
C1 [Goussot, T.; Auxiette, C.; Chambres, P.] Univ Clermont Ferrand, Lab Psychol Sociale & Cognit, Clermont Univ, F-63000 Clermont Ferrand, France.
[Auxiette, C.; Chambres, P.] CNRS, UMR 6024, F-63037 Clermont Ferrand, France.
RP Auxiette, C (reprint author), Univ Clermont Ferrand, Lab Psychol Sociale & Cognit, Clermont Univ, BP 10448, F-63000 Clermont Ferrand, France.
EM catherine.auxiette@univ-bpclermont.fr
CR Abidin R. R., 1983, PARENTING STRESS IND
Altiere MJ, 2009, J CHILD FAM STUD, V18, P83, DOI 10.1007/s10826-008-9209-y
Baghdadli A, 2007, INTERVENTIONS ED PED
BARRERA M, 1981, AM J COMMUN PSYCHOL, V9, P435, DOI 10.1007/BF00918174
Beck AT, 1978, DEPRESSION INVENTORY
BONDY A. S., 1994, PECS PICTURE EXCHANG
Dempsey I, 2009, RES DEV DISABIL, V30, P558, DOI 10.1016/j.ridd.2008.08.005
Dunn EM, 2001, COMMUNITY MENT HLTH, V37, P39
Dunn W, 2002, AM J OCCUP THER, V56, P97
Gray DE, 2002, SOCIOL HEALTH ILL, V24, P734, DOI 10.1111/1467-9566.00316
HAMILTON M, 1960, J NEUROL NEUROSUR PS, V23, P56, DOI 10.1136/jnnp.23.1.56
Hamlyn-Wright S, 2006, AUTISM, V11, P489
Hartmann A, 2008, PRAT PSYCHOL, V14, P285, DOI 10.1016/j.prps.2008.01.002
Hastings RP, 2005, J AUTISM DEV DISORD, V35, P635, DOI 10.1007/s10803-005-0007-8
Hastings RP, 2003, J AUTISM DEV DISORD, V33, P99, DOI 10.1023/A:1022290723442
Hastings RP, 2003, J AUTISM DEV DISORD, V33, P141, DOI 10.1023/A:1022983209004
Heiman T, 2002, J DEV PHYS DISABIL, V14, P159, DOI 10.1023/A:1015219514621
Hochmann J., 2009, HIST AUTISME ENFANT
Howlin P, 1999, DEV MED CHILD NEUROL, V41, P834, DOI 10.1017/S0012162299001656
Kelly AB, 2008, J ABNORM CHILD PSYCH, V36, P1069, DOI 10.1007/s10802-008-9234-8
Khalfa S, 2004, HEARING RES, V198, P87, DOI 10.1016/j.heares.2004.07.006
Lee KG, 2009, J DEV PHYS DISABIL, V21, P93
Lee LC, 2008, J AUTISM DEV DISORD, V38, P1147, DOI 10.1007/s10803-007-0491-0
LOVAAS OI, 1987, J CONSULT CLIN PSYCH, V55, P3, DOI 10.1037/0022-006X.55.1.3
Luminet O, 2000, COGNITION EMOTION, V14, P661
Mesibov GB, 2010, J AUTISM DEV DISORD, V40, P570, DOI 10.1007/s10803-009-0901-6
Milshtein S, 2010, J AUTISM DEV DISORD, V40, P89, DOI 10.1007/s10803-009-0837-x
Mises R, 1997, PARENTS PROFESSIONNE
Orsmond GI, 2009, J AUTISM DEV DISORD, V39, P1053, DOI 10.1007/s10803-009-0722-7
Parquet PJ, 1998, C IM PAR MASS
Pasquier A, 2008, J THERAPIE COMPORTEM, V18, P2, DOI 10.1016/j.jtcc.2008.02.007
Perry A, 2003, PRATIQUES FONDEES RE
Pilowsky T, 2004, J CHILD PSYCHOL PSYC, V45, P855, DOI 10.1111/j.1469-7610.2004.00277.x
Poirier A, 2008, J DEV DISABILITIES, V14, P29
Poirier Annie, 2008, J DEV DISAB, V14, P19
Rogers SJ, 1996, J AUTISM DEV DISORD, V26, P243, DOI 10.1007/BF02172020
Rogers SJ, 2000, J AUTISM DEV DISORD, V30, P399, DOI 10.1023/A:1005543321840
Schopler E, 1990, PSYCHOEDUCATIONAL PR
Siklos S, 2007, RES DEV DISABIL, V28, P9, DOI 10.1016/j.ridd.2005.09.003
Smith LE, 2008, J AUTISM DEV DISORD, V38, P876, DOI 10.1007/s10803-007-0461-6
Verte S, 2003, CHILD CARE HLTH DEV, V29, P193, DOI 10.1046/j.1365-2214.2003.00331.x
Wiggins LD, 2006, J DEV BEHAV PEDIATR, V27, pS79, DOI 10.1097/00004703-200604002-00005
ZIGMOND AS, 1983, ACTA PSYCHIAT SCAND, V67, P361, DOI 10.1111/j.1600-0447.1983.tb09716.x
NR 43
TC 0
Z9 0
PU MASSON EDITEUR
PI MOULINEAUX CEDEX 9
PA 21 STREET CAMILLE DESMOULINS, ISSY, 92789 MOULINEAUX CEDEX 9, FRANCE
SN 0003-4487
J9 ANN MED-PSYCHOL
JI Ann. Med.-Psychol.
PD SEP
PY 2012
VL 170
IS 7
BP 456
EP 460
DI 10.1016/j.amp.2010.11.021
PG 5
WC Pharmacology & Pharmacy; Psychiatry; Psychology; Psychology,
Multidisciplinary
SC Pharmacology & Pharmacy; Psychiatry; Psychology
GA 025KE
UT WOS:000310187000002
ER
PT J
AU Chabane, N
AF Chabane, Nadia
TI The early diagnosis of autism spectrum disorders
SO ANNALES MEDICO-PSYCHOLOGIQUES
LA French
DT Article
DE Autism spectrum disorders
ID INFANT SIBLINGS; LIFE; COMMUNICATION; RISK; POPULATION; PREVALENCE;
REGRESSION; EMERGENCE; TODDLERS; PATTERNS
AB The early detection of autism spectrum disorders represents a crucial stake because it allows to set up an intensive and early adapted care at an age where certain processes of development can still be modified. The recent studies on the very early signs show that TSA does not affect in a objectivised way the development of the socialization in the 12 first months of life. TSA have a gradual beginning, modifying the course of the development and the behavioral patterns between 12 and 36 months. The identification of biological markers would allow to strengthen the strategies of detection and diagnosis in very young children. However, the existence of signs of alert imposes a vast training of the healthcare professionals and the implementation of support strategies for these children in order to modify the spontaneous trajectory of the TSA. (C) 2012 Published by Elsevier Masson SAS.
C1 Hop Robert Debre, Serv Psychopathol Enfant & Adolescent, F-75019 Paris, France.
RP Chabane, N (reprint author), Hop Robert Debre, Serv Psychopathol Enfant & Adolescent, 48 Blvd Serurier, F-75019 Paris, France.
EM nadia.chabane@rdb.aphp.fr
CR Baranek GT, 1999, J AUTISM DEV DISORD, V29, P213, DOI 10.1023/A:1023080005650
BARONCOHEN S, 1996, BRIT J PSYCHIAT, V168, P158, DOI DOI 10.1192/BJP.168.2.158
Dawson G., 2010, PEDIATRICS, V125, P17
Fombonne E, 2001, PEDIATRICS, V107, P411, DOI 10.1542/peds.107.2.411
Garon N, 2009, J ABNORM CHILD PSYCH, V37, P59, DOI 10.1007/s10802-008-9258-0
Hansen RL, 2008, AMBUL PEDIATR, V8, P25, DOI 10.1016/j.ambp.2007.08.006
Ibanez LV, 2008, AUTISM, V12, P473, DOI 10.1177/1362361308094504
Iverson JM, 2007, J AUTISM DEV DISORD, V37, P158, DOI 10.1007/s10803-006-0339-z
Jones W, 2008, ARCH GEN PSYCHIAT, V65, P946, DOI 10.1001/archpsyc.65.8.946
Koegel RL, 2010, J AUTISM DEV DISORD, V40, P516, DOI 10.1007/s10803-009-0933-y
Landa R, 2006, J CHILD PSYCHOL PSYC, V47, P629, DOI 10.1111/j.1469-7610.2006.01531.x
Landa RJ, 2007, ARCH GEN PSYCHIAT, V64, P853, DOI 10.1001/archpsyc.64.7.853
Lingam R, 2003, ARCH DIS CHILD, V88, P666, DOI 10.1136/adc.88.8.666
Loh A, 2007, J AUTISM DEV DISORD, V37, P25, DOI 10.1007/s10803-006-0333-5
Luyster R, 2005, DEV NEUROPSYCHOL, V27, P311, DOI 10.1207/s15326942dn2703_2
Nadig AS, 2007, ARCH PEDIAT ADOL MED, V161, P378, DOI 10.1001/archpedi.161.4.378
Ozonoff S, 2010, J AM ACAD CHILD PSY, V49, P256, DOI 10.1016/j.jaac.2009.11.009
Ozonoff S, 2008, AUTISM RES, V1, P320, DOI 10.1002/aur.53
Palomo R, 2006, J DEV BEHAV PEDIATR, V27, pS59, DOI 10.1097/00004703-200604002-00003
Pierce K, 2011, J PEDIATR-US, V159, P458, DOI 10.1016/j.jpeds.2011.02.036
Pierce K, 2011, ARCH GEN PSYCHIAT, V68, P101, DOI 10.1001/archgenpsychiatry.2010.113
Rogers SJ, 2009, AUTISM RES, V2, P125, DOI 10.1002/aur.81
Stone WL, 2000, J AUTISM DEV DISORD, V30, P607, DOI 10.1023/A:1005647629002
Swinkels SHN, 2006, J AUTISM DEV DISORD, V36, P723, DOI 10.1007/s10803-006-0115-0
VOLKMAR FR, 1994, AM J PSYCHIAT, V151, P1361
Werner E, 2000, J AUTISM DEV DISORD, V30, P157, DOI 10.1023/A:1005463707029
Wetherby AM, 2004, J AUTISM DEV DISORD, V34, P473, DOI 10.1007/s10803-004-2544-y
Yoder P, 2006, J SPEECH LANG HEAR R, V49, P698, DOI 10.1044/1092-4388(2006/051)
Zwaigenbaum L, 2005, INT J DEV NEUROSCI, V23, P143, DOI 10.1016/j.ijdevneu.2004.05.001
NR 29
TC 0
Z9 0
PU MASSON EDITEUR
PI MOULINEAUX CEDEX 9
PA 21 STREET CAMILLE DESMOULINS, ISSY, 92789 MOULINEAUX CEDEX 9, FRANCE
SN 0003-4487
EI 1769-6631
J9 ANN MED-PSYCHOL
JI Ann. Med.-Psychol.
PD SEP
PY 2012
VL 170
IS 7
BP 462
EP 465
DI 10.1016/j.amp.2012.07.002
PG 4
WC Pharmacology & Pharmacy; Psychiatry; Psychology; Psychology,
Multidisciplinary
SC Pharmacology & Pharmacy; Psychiatry; Psychology
GA 025KE
UT WOS:000310187000004
ER
PT J
AU Tonus, A
AF Tonus, Adelaide
TI Asperger's syndrome: An early diagnosis in a unique discussed category?
SO ANNALES MEDICO-PSYCHOLOGIQUES
LA French
DT Article
DE Asperger's syndrome; Autism; Children
ID HIGH-FUNCTIONING AUTISM; DISORDER
AB The trend currently observed goes towards regrouping all various autistic syndromes under one unique category, the autism-spectrum disorder. Asperger's syndrome could therefore disappear from the international classifications for mental illnesses. Indeed, the lack of general consensus on Asperger's definition is by essence an argument against the syndrome's own existence. Moreover, the distinction between Asperger's syndrome and high level autism is blurry for the least. The differences between the two disorders are measurable in terms of symptomatic intensity rather than in terms of truly distinctive symptomatic profiles, which also argues in favor of the continuity of the autism-spectrum. Several years separate the appearance of the first autistic symptoms and the final diagnosis for autism, especially for Asperger's as it is defined today. However, the first clinical signs of autism occur/manifest during early childhood. Thus, taking a closer interest at the child's psychomotor development could favor an early diagnosis of Asperger's syndrome. Movement, which can be defined as the first sign of language, could therefore be used as a mean to diagnose and study the different types of autistic disorders. Even if no early signs of Asperger syndrome manifest, parents should nonetheless react in the same manner as autism (i.e. by setting up tools of adaptation to socialization very early). The primary benefit of early diagnosis is foremost the higher efficiency of early treatment. (C) 2012 Elsevier Masson SAS. All rights reserved.
C1 Hop Robert Debre, Serv Psychopathol Enfant & Adolescent, F-75019 Paris, France.
RP Tonus, A (reprint author), Hop Robert Debre, Serv Psychopathol Enfant & Adolescent, 48 Blvd Serurier, F-75019 Paris, France.
EM delle.h@hotmail.fr
CR Bennett T, 2008, J AUTISM DEV DISORD, V38, P616, DOI 10.1007/s10803-007-0428-7
Ehlers F, 1999, J AUTISM DEV DISORD, V29, P129
Fombonne E, 2005, J CLIN PSYCHIAT, V66, P3
Garnett M, 1995, AUSTR NAT AUT C
Howlin P, 1999, DEV MED CHILD NEUROL, V41, P834, DOI 10.1017/S0012162299001656
Kopra K, 2008, J AUTISM DEV DISORD, V38, P1567, DOI 10.1007/s10803-008-0537-y
Macintosh K, 2006, J AUTISM DEV DISORD, V36, P1065, DOI 10.1007/s10803-006-0139-5
Noterdaeme M, 2010, EUR CHILD ADOLES PSY, V19, P475, DOI 10.1007/s00787-009-0057-0
South M, 2005, J AUTISM DEV DISORD, V35, P145, DOI 10.1007/s10803-005-1992-3
Szatmari P, 2009, J CHILD PSYCHOL PSYC, V50, P1459, DOI 10.1111/j.1469-7610.2009.02123.x
Teitelbaum O, 2004, P NATL ACAD SCI USA, V101, P11909, DOI 10.1073/pnas.0403919101
Verte S, 2006, AUTISM, V10, P266, DOI 10.1177/1362361306063299
WING L, 1981, PSYCHOL MED, V11, P115
NR 13
TC 0
Z9 0
PU MASSON EDITEUR
PI MOULINEAUX CEDEX 9
PA 21 STREET CAMILLE DESMOULINS, ISSY, 92789 MOULINEAUX CEDEX 9, FRANCE
SN 0003-4487
J9 ANN MED-PSYCHOL
JI Ann. Med.-Psychol.
PD SEP
PY 2012
VL 170
IS 7
BP 467
EP 470
DI 10.1016/j.amp.2012.06.022
PG 4
WC Pharmacology & Pharmacy; Psychiatry; Psychology; Psychology,
Multidisciplinary
SC Pharmacology & Pharmacy; Psychiatry; Psychology
GA 025KE
UT WOS:000310187000006
ER
PT J
AU Cappe, E
AF Cappe, Emilie
TI Effect of social and school inclusion on adjustment and quality of life
of parents with a child having an autism spectrum disorder
SO ANNALES MEDICO-PSYCHOLOGIQUES
LA French
DT Article
DE Adjustment; Autism spectrum disorder; Parents; Quality of life
ID ASPERGER SYNDROME; ADAPTATION
AB Social and school inclusion for people with autistic spectrum disorder is an important current issue. Thus, the objective of this study was to consider the effect of social and school inclusion on parents' adjustment and quality of life. We met 160 parents who filled out several self-rating scales for assessing: 1) information about the child and the family situation; 2) perceived stress; 3) perceived social support; 4) perceived control; 5) coping strategies; 6) quality of life. The results show that parents with a child who goes to school and those with a child who has leisure activities in ordinary environment, are less stressed, use more effective coping strategies and have a better quality of life. (C) 2012 Elsevier Masson SAS. All rights reserved.
C1 Univ Paris 05, LPPS, EA 4057, Inst Psychol, F-92100 Boulogne, France.
RP Cappe, E (reprint author), Univ Paris 05, LPPS, EA 4057, Inst Psychol, 71 Ave Edouard Vaillant, F-92100 Boulogne, France.
EM emilie.cappe@parisdescartes.fr
CR Bruchon-Schweitzer M., 1994, INTRO PSYCHOL SANTE
Bruchon-Schweitzer M., 2002, PSYCHOL SANTE MODELE
Cappe E, 2012, EVOL PSYCHIATR, V77, P181, DOI 10.1016/j.evopsy.2012.01.008
Cappe E., 2009, REV QUE PSYCHOL, V30, P137
Cappe E, 2011, QUAL LIFE RES, V20, P1279, DOI 10.1007/s11136-011-9861-3
Cappe E, 2009, PSYCHIAT ENFANT, V52, P201
Cappe E., 2011, AUTISME ENFANT EVALU, P87
Centre d'expertise collective de l'Inserm, 2002, TROUBL MENT DEP PREV
Chossy JF, 2003, SITUATION PERSONNES
Comite Consultatif National d'Ethique, 2007, CAHIERS CCNE, V54, P1
Cousson F, 1996, PSYCHOL FR, V41-2, P155
Cousson-Gelie F, 1997, THESIS U BORDEAUX 2
Ferguson E, 1999, BRIT J HEALTH PSYCH, V4, P97, DOI 10.1348/135910799168506
Koleck M, 2000, THESIS U BORDEAUX 2
Pruyn J., 1988, TIJDSCHR SOC GEZONDH, V66, P404
Richieri R, 2011, SCHIZOPHR RES, V126, P192, DOI 10.1016/j.schres.2010.08.037
Soria C, 2008, DEV NEUROREHABIL, V11, P268, DOI 10.1080/17518420802551498
VITALIANO PP, 1985, MULTIVAR BEHAV RES, V20, P3, DOI 10.1207/s15327906mbr2001_1
NR 18
TC 0
Z9 0
PU MASSON EDITEUR
PI MOULINEAUX CEDEX 9
PA 21 STREET CAMILLE DESMOULINS, ISSY, 92789 MOULINEAUX CEDEX 9, FRANCE
SN 0003-4487
J9 ANN MED-PSYCHOL
JI Ann. Med.-Psychol.
PD SEP
PY 2012
VL 170
IS 7
BP 471
EP 475
DI 10.1016/j.amp.2012.06.015
PG 5
WC Pharmacology & Pharmacy; Psychiatry; Psychology; Psychology,
Multidisciplinary
SC Pharmacology & Pharmacy; Psychiatry; Psychology
GA 025KE
UT WOS:000310187000007
ER
PT J
AU Delorme, R
Mouren, MC
AF Delorme, Richard
Mouren, Marie-Christine
TI Autism Spectrum Disorders: What do we learn from genetics?
SO ANNALES MEDICO-PSYCHOLOGIQUES
LA French
DT Article
DE Autism; Gene; Mutations; Phenotype
ID MENTAL-RETARDATION; MUTATIONS; NEUROLIGINS; REVEALS; LINKAGE; GENES;
NLGN4; SCAN; RISK; LOCI
AB Autism spectrum disorders (ASD) are a heterogeneous group of pervasive neurodevelopmental disorders affecting 1% of the population. The diagnosis of ASD is based on impairments in reciprocal social communication and stereotyped behaviors. It is now understood that autism symptoms can be caused either by gene mutations or by chromosomal aberrations. In the last years, various independent studies and large-scale international efforts have identified rare variants, copy number variants (CNVs) and single nucleotide variants (SNVs) associated with ASD and suggested a set of mechanisms that could underlie the ASD phenotype. In this review, we present the main rare variants associated with ASD as well as early findings on the identification of common variants as risk factors. A better characterization of the genetic and phenotypic heterogeneity of ASD will help to understand the epistasis between the rare and common variants. (C) 2012 Published by Elsevier Masson SAS.
C1 [Delorme, Richard; Mouren, Marie-Christine] Hop Robert Debre, Serv Pedopsychiat, F-75019 Paris, France.
[Delorme, Richard] Inst Pasteur, CNRS URA2182, Paris, France.
RP Delorme, R (reprint author), Hop Robert Debre, Serv Pedopsychiat, 48 Blvd Serurier, F-75019 Paris, France.
EM richard.delorme@rdb.aphp.fr
CR Anney R, 2010, HUM MOL GENET, V19, P4072, DOI 10.1093/hmg/ddq307
BAILEY A, 1995, PSYCHOL MED, V25, P63
Berkel S, 2010, NAT GENET, V42, P489, DOI 10.1038/ng.589
Bucan M, 2009, PLOS GENET, V5, DOI 10.1371/journal.pgen.1000536
Chubykin AA, 2005, J BIOL CHEM, V280, P22365, DOI 10.1074/jbc.M410723200
Durand CM, 2007, NAT GENET, V39, P25, DOI 10.1038/ng1933
Fombonne E, 1997, J AM ACAD CHILD PSY, V36, P1561, DOI 10.1016/S0890-8567(09)66566-7
Glessner JT, 2009, NATURE, V459, P569, DOI 10.1038/nature07953
Hogart A, 2010, NEUROBIOL DIS, V38, P181, DOI 10.1016/j.nbd.2008.08.011
Jamain S, 2003, NAT GENET, V34, P27, DOI 10.1038/ng1136
Laumonnier F, 2004, AM J HUM GENET, V74, P552, DOI 10.1086/382137
Marshall CR, 2008, AM J HUM GENET, V82, P477, DOI 10.1016/j.ajhg.2007.12.009
Pinto O, 2010, NATURE, V466, P368
Sebat J, 2007, SCIENCE, V316, P445, DOI 10.1126/science.1138659
State MW, 2010, NAT GENET, V42, P478, DOI 10.1038/ng0610-478
Szatmari P, 2007, NAT GENET, V39, P319, DOI 10.1038/ng1985
Toro R, 2010, TRENDS GENET, V26, P363, DOI 10.1016/j.tig.2010.05.007
Volkmar FR, 2009, J CHILD PSYCHOL PSYC, V50, P108, DOI 10.1111/j.1469-7610.2008.02010.x
Wang K, 2009, NATURE, V459, P528, DOI 10.1038/nature07999
Weiss LA, 2009, NATURE, V461, P802, DOI 10.1038/nature08490
NR 20
TC 0
Z9 0
PU MASSON EDITEUR
PI MOULINEAUX CEDEX 9
PA 21 STREET CAMILLE DESMOULINS, ISSY, 92789 MOULINEAUX CEDEX 9, FRANCE
SN 0003-4487
J9 ANN MED-PSYCHOL
JI Ann. Med.-Psychol.
PD SEP
PY 2012
VL 170
IS 7
BP 476
EP 478
DI 10.1016/j.amp.2012.07.001
PG 3
WC Pharmacology & Pharmacy; Psychiatry; Psychology; Psychology,
Multidisciplinary
SC Pharmacology & Pharmacy; Psychiatry; Psychology
GA 025KE
UT WOS:000310187000009
ER
PT J
AU Bargiacchi, A
AF Bargiacchi, Anne
TI Contribution of the technology of the new brain RMI images in the autism
spectrum disorders
SO ANNALES MEDICO-PSYCHOLOGIQUES
LA French
DT Article
DE Autism; Autism spectrum disorders; Default brain network; IRM; PET scan;
Social brain
ID HIGH-FUNCTIONING AUTISM; SUPERIOR TEMPORAL SULCUS; VOXEL-BASED
MORPHOMETRY; CHILDHOOD AUTISM; WHITE-MATTER; SENTENCE COMPREHENSION;
CORTICAL ACTIVATION; SOCIAL-PERCEPTION; CORPUS-CALLOSUM; WORKING-MEMORY
AB Understanding the brain abnormalities present in autistic patients has evolved considerably since the advent of MRI and functional imaging. Recent techniques for acquiring and processing images allow a fine analysis of anatomical, functional and statistical processing of the images. Currently, studies converge to establish the existence of anatomic and functional abnormalities ties in areas of "social brain" in autism. First, the visual analysis of brain MR images of a group of autistic children showed the presence of abnormalities mainly localized in the temporal lobe. On the other hand, statistical analyzes show a decrease in gray matter in regions of the "social brain" in individuals with autism compared to a group of controls. Functional studies (PET scan) show a decrease in cerebral blood flow at rest in the same regions in patients. Hypo-activation in the area specialized in the treatment of the human voice in the superior temporal sulcus in patients is also described, but also the hypo-activation of brain regions involved in more complex tasks of social cognition. Abnormalities of the anatomical and functional connectivity between frontal and temporal regions have been highlighted in several studies. Finally, very recent studies concerned with the "default brain network" suggest functional alterations of this circuit in this disorder. These areas (social brain, default brain network) are involved in processing stimuli necessary for social and emotional life. The abnormalities found may thus partly explain the profound abnormalities in social behavior in individuals with autism. (C) 2012 Published by Elsevier Masson SAS.
C1 Hop Robert Debre, Serv Psychiat Enfant & Adolescent, F-75019 Paris, France.
RP Bargiacchi, A (reprint author), Hop Robert Debre, Serv Psychiat Enfant & Adolescent, 48 Blvd Serurier, F-75019 Paris, France.
EM annebargiacchi@gmail.com
CR Adolphs R, 2003, NAT REV NEUROSCI, V4, P165, DOI 10.1038/nrn1056
Alexander AL, 2007, NEUROIMAGE, V34, P61, DOI 10.1016/j.neuroimage.2006.08.032
Allison T, 2000, TRENDS COGN SCI, V4, P267, DOI 10.1016/S1364-6613(00)01501-1
Assaf M, 2010, NEUROIMAGE, V53, P247, DOI 10.1016/j.neuroimage.2010.05.067
Boddaert N, 2004, NEUROIMAGE, V23, P364, DOI 10.1016/j.neuroimage.2004.06.016
Boddaert N, 2004, AM J PSYCHIAT, V161, P2117, DOI 10.1176/appi.ajp.161.11.2117
Boddaert N, 2003, AM J PSYCHIAT, V160, P2057, DOI 10.1176/appi.ajp.160.11.2057
Boddaert N, 2002, PEDIATR RADIOL, V32, P1
Castelli F, 2002, BRAIN, V125, P1839, DOI 10.1093/brain/awf189
Cattaneo L, 2007, P NATL ACAD SCI USA, V104, P17825, DOI 10.1073/pnas.0706273104
Courchesne E, 2001, NEUROLOGY, V57, P245
Critchley HD, 2000, BRAIN, V123, P2203, DOI 10.1093/brain/123.11.2203
Dalton KM, 2005, NAT NEUROSCI, V8, P519, DOI 10.1038/nn1421
Dapretto M, 2006, NAT NEUROSCI, V9, P28, DOI 10.1038/nn1611
Gervais H, 2004, NAT NEUROSCI, V7, P801, DOI 10.1038/nn1291
Hadjikhani N, 2004, NEUROIMAGE, V22, P1141, DOI 10.1016/j.neuroimage.2004.03.025
Hadjikhani N, 2006, CEREB CORTEX, V16, P1276, DOI 10.1093/cercor/bh069
Just MA, 2007, CEREB CORTEX, V17, P951, DOI 10.1093/cercor/bhl006
Just MA, 2004, BRAIN, V127, P1811, DOI 10.1093/brain/awh199
Kana RK, 2009, SOC NEUROSCI-UK, V4, P135, DOI 10.1080/17470910802198510
Kana RK, 2006, BRAIN, V129, P2484, DOI 10.1093/brain/awl164
Kana RK, 2007, BIOL PSYCHIAT, V62, P198, DOI 10.1016/j.biopsych.2006.08.004
Kanwisher N, 1997, J NEUROSCI, V17, P4302
Ke XY, 2009, BRAIN RES, V1265, P171, DOI 10.1016/j.brainres.2009.02.013
Keller TA, 2007, NEUROREPORT, V18, P23, DOI 10.1097/01.wnr.0000239965.21685.99
Koshino H, 2008, CEREB CORTEX, V18, P289, DOI 10.1093/cercor/bhm054
Koshino H, 2005, NEUROIMAGE, V24, P810, DOI 10.1016/j.neuroimage.2004.09.028
Lee JE, 2007, NEUROSCI LETT, V424, P127, DOI 10.1016/j.neulet.2007.07.042
Monk CS, 2009, NEUROIMAGE, V47, P764, DOI 10.1016/j.neuroimage.2009.04.069
Sundaram SK, 2008, CEREB CORTEX
Weng SJ, 2010, BRAIN RES, V1313, P202, DOI 10.1016/j.brainres.2009.11.057
Zilbovicius M, 2000, AM J PSYCHIAT, V157, P1988, DOI 10.1176/appi.ajp.157.12.1988
Zilbovicius M, 2006, TRENDS NEUROSCI, V29, P359, DOI 10.1016/j.tins.2006.06.004
NR 33
TC 0
Z9 0
PU MASSON EDITEUR
PI MOULINEAUX CEDEX 9
PA 21 STREET CAMILLE DESMOULINS, ISSY, 92789 MOULINEAUX CEDEX 9, FRANCE
SN 0003-4487
J9 ANN MED-PSYCHOL
JI Ann. Med.-Psychol.
PD SEP
PY 2012
VL 170
IS 7
BP 479
EP 481
DI 10.1016/j.amp.2012.07.006
PG 3
WC Pharmacology & Pharmacy; Psychiatry; Psychology; Psychology,
Multidisciplinary
SC Pharmacology & Pharmacy; Psychiatry; Psychology
GA 025KE
UT WOS:000310187000010
ER
PT J
AU Cuny, F
AF Cuny, Francine
TI Social habilities training groups
SO ANNALES MEDICO-PSYCHOLOGIQUES
LA French
DT Article
DE Asperger's Syndrome; High-functioning Autism disorder; Social Skills;
Training
AB The biggest challenge for individuals with Asperger's Syndrome (AS) or High Functioning Autism disorder (HFAd) is to know how to communicate and interact with others in a social setting. Individuals AS and HFA do not know or use the basis skills that come naturally to other people. Those social skills being the basis for almost all relationships, personal as well as business, individuals AS and FIFA therefore need specific treatment to help them. Professionals try to find resources to guide them and social skills training groups can provide this help. (C) 2012 Published by Elsevier Masson SAS.
C1 Hop Robert Debre, Serv Pr Mouren, F-75019 Paris, France.
RP Cuny, F (reprint author), Hop Robert Debre, Serv Pr Mouren, 48 Blvd Serurier, F-75019 Paris, France.
EM francine_cuny@hotmail.com
CR Cuny F, 2010, AIDES COMMUNICATION
Liberman RP, 2005, ENTRAINEMENT HABILET
Michelson L., 1983, SOCIAL SKILLS ASSESS
Segar M, 1998, FAIRE FACE GUIDE SUR
NR 4
TC 0
Z9 0
PU MASSON EDITEUR
PI MOULINEAUX CEDEX 9
PA 21 STREET CAMILLE DESMOULINS, ISSY, 92789 MOULINEAUX CEDEX 9, FRANCE
SN 0003-4487
J9 ANN MED-PSYCHOL
JI Ann. Med.-Psychol.
PD SEP
PY 2012
VL 170
IS 7
BP 482
EP 484
DI 10.1016/j.amp.2012.06.017
PG 3
WC Pharmacology & Pharmacy; Psychiatry; Psychology; Psychology,
Multidisciplinary
SC Pharmacology & Pharmacy; Psychiatry; Psychology
GA 025KE
UT WOS:000310187000012
ER
PT J
AU Recordon-Gaboriaud, S
AF Recordon-Gaboriaud, Severine
TI Clinical evaluation of adults with autism and associated with an
intellectual deficiency: The need for a personalised accompaniment
SO ANNALES MEDICO-PSYCHOLOGIQUES
LA French
DT Article
DE Adult aged; Autism; Behavioural problems diagnostic; Functional
evaluation; Individualised project
ID INDIVIDUALS; DISORDERS; SPECTRUM
AB The recognition of specific needs for adults with autism and other pervasive developmental disorders regarding diagnostics and functional evaluations have allowed the High Authority on Health care (HAS), in July 2011, to establish recommendations on good professional practices. These recommendations legitimise the importance of regular evaluations. Consequently, patient's accompaniment and life projects can be thought out realistically according to their actual resources in terms of autonomy, communication, participation in social and community life. However, when autism is associated to an intellectual deficiency, particularly in severe cases, these patients need pluridisciplinary teams to adjust the evaluation framework. Thus, it also implies new thoughts on which tools and tests should be used to significantly link evaluation conclusions with the use of coordinated interventions with these patients. To obtain a rigorous framework in which to pass psychological tests, the diagnostic approach must be completed by the evaluation of a patient's functioning's. These tested patients must be able to put into perspective their strengths and specificities. In this endeavour, the recourse to adapted tools that help a situational or functional evaluation is necessary for pragmatic reasons as well as for the individualization of a educational and therapeutical support in their every day life. Several specific tools, adapted for adults with autism and covering different expertise's can be used during an evaluation. At the same time, tests concerning behavioural problems, when present and with pervasive components, can be conducted by using two descriptive and functional approaches. These approaches have a complementarity that is useful for a subtle exploration of problems encountered. It can also be an important element to help define and develop a support program for behaviours. (C) 2012 Elsevier Masson SAS. All rights reserved.
C1 ADAPEI 79, Residence Archipel, F-79500 St Martin Les Melle, France.
RP Recordon-Gaboriaud, S (reprint author), ADAPEI 79, Residence Archipel, Maison Autisme,Route Mothe St Heray, F-79500 St Martin Les Melle, France.
EM s.gaboriaud@adapei79.org
CR American Psychiatric Association, 2004, DSM 4 TR MAN DIAGN S
Barthelemy C., 2003, ECHELLE EVALUATION C
Carter AS, 1998, J AUTISM DEV DISORD, V28, P287, DOI 10.1023/A:1026056518470
Gualteri CT, 2005, ADV PSYCHOL RES, V27, P183
Johnny L, 2007, J DEV PHYS DISABIL, V19, P557
L'Abbe Y., 2001, COMPORTEMENTS AGRESS
LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
Magerotte C, 2001, MANUEL PSYCHOL HANDI, P359
Magerotte G, 2001, QUALITE VIE PERSONNE
Maurice P, 1988, ECHELLE QUEBECOISE C
Mesibov G, 1997, PROFIL PSYCHOEDUCATI
O'Neil E, 2008, EVALUATION FONCTIONN
O'Neil R, 1989, POSITIVE BEHAV SUPPO
O'Neil R, 1990, FUNCTIONAL ANAL PRAC
O'Neil R. E., 1997, FUNCTIONAL ASSESSMEN
Qureshi H, 1994, SEVER LEARNING DISAB
Recordon-Gaboriaud S, 2009, PRATIQUES SANTE MENT
Recordon-Gaboriaud S, 2009, B SCI ARAPI
Recordon-Gaboriaud S, 2010, B SCI ARAPI
Recordon-Gaboriaud S, 2012, ECHELLE OBSERVATION
Recordon-Gaboriaud S, 2008, B SCI ARAPI
Recordon-Gaboriaud S, 2008, B SCI ARAPI
Recordon-Gaboriaud S., 2007, THESIS U PARIS DESCA
Recordon-Gaboriaud S, 2004, ACT C ADAPEI79 AD AV
Reichler R, 1970, PSYCHOEDUCATIONNAL P
Roge B., 2000, TROUBLES COMPORTEMEN
Rojahn J, 2005, ADV PSYCHOL RES, V27, P183
Schopler E, 1979, PSYCHOEDUCATIONAL PR
Schopler E, 1985, AUTISM ADOLESCENTS A
Schopler E, 1994, AUTISM COMMUN, V26, P44
Schopler E., 1997, PARENTS PROFESSIONNE, P191
Schopler E, 1994, PROFIL PSYCHOEDUCATI
Schopler E, 1998, STRATEGIES ED AUTISM
Schopler E, 1980, TEACHING STRATEGIES
Seltzer MM, 2003, J AUTISM DEV DISORD, V33, P565, DOI 10.1023/B:JADD.0000005995.02453.0b
Sparrow S, 1984, VINELAND ADAPTATIVE
Unapei, 2007, AUT EST ON AUJ ET CO
Willaye E, 2005, EFI EVALUATION COMPE
Willaye E, 2008, EVALUATION INTERVENT
Willaye E, 2003, DEFICIENCE INTELLECT, P245
World Health Organization, 1993, CIM 10 ICD 10 INT CL
NR 42
TC 0
Z9 0
PU MASSON EDITEUR
PI MOULINEAUX CEDEX 9
PA 21 STREET CAMILLE DESMOULINS, ISSY, 92789 MOULINEAUX CEDEX 9, FRANCE
SN 0003-4487
J9 ANN MED-PSYCHOL
JI Ann. Med.-Psychol.
PD SEP
PY 2012
VL 170
IS 7
BP 485
EP 490
DI 10.1016/j.amp.2012.08.003
PG 6
WC Pharmacology & Pharmacy; Psychiatry; Psychology; Psychology,
Multidisciplinary
SC Pharmacology & Pharmacy; Psychiatry; Psychology
GA 025KE
UT WOS:000310187000014
ER
PT J
AU Brunod, R
AF Brunod, Regis
TI Autism Resources Center for Paris and suburbs area (CRAIF)
SO ANNALES MEDICO-PSYCHOLOGIQUES
LA French
DT Article
DE Autism; Counseling; Education; Information; Resources Center
AB Paris area is a complex urban area where 12 million people are living. This complexity is also encountered by the parents of children or the adults with autism or others Pervasive Developmental Disorders. More specifically it could be difficult for them to get a diagnosis or to find the right way to get measures really appropriate to their situations. To help them a specific structure called "Centre de Ressources Autisme Ile-de-France" (CRAIF, Center for Resources in Autism, Paris Area) was created in 2004. Several professionals (librarian, social worker, psychologist, doctor, management secretary and manager) try to give information or advice in various manners (phone, mail, e-mail, visiting...) to the people (families or professionals) searching help. In this paper we report the various missions of this institution and the way its professionals try to answer. (C) 2012 Elsevier Masson SAS. All rights reserved.
C1 CRAIF, F-75012 Paris, France.
RP Brunod, R (reprint author), CRAIF, 27 Rue Rambouillet, F-75012 Paris, France.
EM r.brunod@craif.org
NR 0
TC 0
Z9 0
PU MASSON EDITEUR
PI MOULINEAUX CEDEX 9
PA 21 STREET CAMILLE DESMOULINS, ISSY, 92789 MOULINEAUX CEDEX 9, FRANCE
SN 0003-4487
J9 ANN MED-PSYCHOL
JI Ann. Med.-Psychol.
PD SEP
PY 2012
VL 170
IS 7
BP 491
EP 493
DI 10.1016/j.amp.2012.08.002
PG 3
WC Pharmacology & Pharmacy; Psychiatry; Psychology; Psychology,
Multidisciplinary
SC Pharmacology & Pharmacy; Psychiatry; Psychology
GA 025KE
UT WOS:000310187000015
ER
PT J
AU Murad, A
Fritsch, A
Lecomte, F
Stojanovic, J
Haegele, M
AF Murad, Ayman
Fritsch, Aurelie
Lecomte, Florence
Stojanovic, Jeanne
Haegele, Marie
TI Anger management in adult people with autism spectrum disorders
SO ANNALES MEDICO-PSYCHOLOGIQUES
LA French
DT Article
DE Aggressive behavior; Anger management; Autism; Autism spectrum
disorders; Mental retardation; Pervasive developmental disorders
AB Anger-management programs based on cognitive-behavioral conceptualization of anger have been successfully used in different types of populations. In this paper, we describe a program adapted to adult people with autism spectrum disorders and mental retardation. The program is implemented in a day-care unit. Ten patients are divided into three groups, depending on their specific difficulties. Cognitive-behavioral techniques have been adapted to be understood and practiced by patients. Visual formats, repetition, and imitation are examples of strategies that help people with autism and mental retardation identify emotions and cope with excessive anger. We also discuss evaluation of this type of therapy. (C) 2012 Elsevier Masson SAS. All rights reserved.
C1 [Murad, Ayman; Fritsch, Aurelie; Lecomte, Florence; Stojanovic, Jeanne; Haegele, Marie] Espace Autismes 68 Ctr Hosp Rouffach, F-68000 Colmar, France.
RP Murad, A (reprint author), Espace Autismes 68 Ctr Hosp Rouffach, 13 Rue Charles Sandherr, F-68000 Colmar, France.
EM a.murad@ch-rouffach.fr
CR American Psychiatric Association, 2005, DSM 4 TR MAN DIAGN S
[Anonymous], 1992, CLASS INT TROUBL MEN
Fritsch A, 2009, ANN MED-PSYCHOL, V167, P299, DOI 10.1016/j.amp.2009.02.005
Galdin M, 2011, REV FRANCOPHONE DEFI, V22, P112
Novaco R.W., 1975, ANGER CONTROL DEV EV
Sofronoff K, 2007, J AUTISM DEV DISORD, V37, P1203, DOI 10.1007/s10803-006-0262-3
Taylor JL, 2005, ANGER TREATMENT FOR PEOPLE WITH DEVELOPMENTAL DISABILITIES: A THEORY, EVIDENCE AND MANUAL BASED APPROACH, P1, DOI 10.1002/9780470713631
NR 7
TC 1
Z9 1
PU MASSON EDITEUR
PI MOULINEAUX CEDEX 9
PA 21 STREET CAMILLE DESMOULINS, ISSY, 92789 MOULINEAUX CEDEX 9, FRANCE
SN 0003-4487
J9 ANN MED-PSYCHOL
JI Ann. Med.-Psychol.
PD SEP
PY 2012
VL 170
IS 7
BP 494
EP 496
DI 10.1016/j.amp.2012.06.014
PG 3
WC Pharmacology & Pharmacy; Psychiatry; Psychology; Psychology,
Multidisciplinary
SC Pharmacology & Pharmacy; Psychiatry; Psychology
GA 025KE
UT WOS:000310187000016
ER
PT J
AU Connan, A
Haegele, M
Wittner, G
Murad, A
AF Connan, Aurelie
Haegele, Marie
Wittner, Guy
Murad, Ayman
TI A mobile team for adult people with autism spectrum disorders
SO ANNALES MEDICO-PSYCHOLOGIQUES
LA French
DT Article
DE Autism; Autism spectrum disorder; Behavior disorders; Mobile team;
Pervasive developmental disorders
AB A mobile team dedicated to adult people with autism was created in the Alsace region (France) in 2009. It intervenes in the patient's everyday environment in conjunction with the patient's family or the medical staff in order to get a better view of the various environmental factors that may have an influence on the patient's difficulties. The team's staff has been trained to perform functional analysis of behavior disorders as well as to use specific tools intended to facilitate communication in autism. The mobile team offers help to patients, their families, and professionals caring for them. Three main missions have been assigned to this facility: intervention in case of behavior disorders, implementation of special strategies to help people with autism communicate or organize their time and space, and support for patients when they are hospitalized and when they have to undergo medical examinations. (C) 2012 Elsevier Masson SAS. All rights reserved.
C1 [Connan, Aurelie; Haegele, Marie; Wittner, Guy; Murad, Ayman] Espace Autismes 68 Ctr Hosp Rouffach, F-68000 Colmar, France.
RP Connan, A (reprint author), Espace Autismes 68 Ctr Hosp Rouffach, 13 Rue Charles Sandherr, F-68000 Colmar, France.
EM equipemob.autisme@ch-rouffach.fr
CR Constant J, 2002, CARNET PSY, V7, P28
Guastalli H, 2004, EMPAN, V2, P93
O'Neill RE, 2008, EVALUATION FONCTIONN
Schopler E, 1997, PROFIL PSYCHOEDUCATI
Treese Daquin C, 2009, SESSAD AUTISME ACCOM
Willaye E, 2008, EVALUATION INTERVENT
Willaye E, 2005, EVALUATION COMPETENC
NR 7
TC 0
Z9 0
PU MASSON EDITEUR
PI MOULINEAUX CEDEX 9
PA 21 STREET CAMILLE DESMOULINS, ISSY, 92789 MOULINEAUX CEDEX 9, FRANCE
SN 0003-4487
J9 ANN MED-PSYCHOL
JI Ann. Med.-Psychol.
PD SEP
PY 2012
VL 170
IS 7
BP 497
EP 501
DI 10.1016/j.amp.2012.06.016
PG 5
WC Pharmacology & Pharmacy; Psychiatry; Psychology; Psychology,
Multidisciplinary
SC Pharmacology & Pharmacy; Psychiatry; Psychology
GA 025KE
UT WOS:000310187000018
ER
PT J
AU Sauvage, D
AF Sauvage, Dominique
TI Autism: A short story of nosology
SO ANNALES MEDICO-PSYCHOLOGIQUES
LA French
DT Article
DE Autism; Classifications; Nosography; Pervasive developmental disorders
ID DISORDERS
AB Kanner (1943) and Asperger (1944) have given the name of autism to the mental disorder formerly called idiotism and later psychoses or sometimes childhood schizophrenia. These authors bring to the disorder a better definition and establish its very early beginning during infancy. Kanner considers it belongs to the field of the psychoses and discusses its relation to schizophrenia. His report introduces two strong and controversal subjects: firstly about the intelligence of autistic people and secondly the typology of their families. Asperger gives more importance to the mental development and does not mention pejorative familial caracteristics. He also noticed the good or exceptional capacities of some cases by citing the observations of four of them. This is the reason his name is associated today with the less severe forms of the syndrome. During the 19th century, psychiatrists had begun to develop an interest in the classification of infantile psychoses and Seguin - formerly a teacher of children with special needs - gave an illustration of it with his study of the Idiots (annex). But, few authors described the mental diseases of the child as distinct from those of the adult. For example, Kraepelin and Bleuler who mention some cases beginning during childhood, do not treat infantile mental troubles as such and it will be a long time before early psychoses become the subjects of specific research. During the years between 1940 and 1960, there was a revival of interest in autism due to the commonality of symptoms linking it to the most severe cases of affective deprivation in studies of the mother-child relationship. A comparison which leads some influential authors to confuse autism with the effects of this severe deficiency, going as far as to attribute it to disturbed mothering, at a subconcious level, as there is no clear maternal inadequacy. The medical approach is completely different. Developmental disorders cannot be explained as the consequence of unfavourable life experiences and more and more facts support a neurobiological etiology. Autism is considered as a group of various disorders having a common phenotype of Pervasive Developmental Desorder (PDD). DSM and more recently CIM are in phase with this new approach. They enlarge the field of the PDD, as the result of which there is a change in the reported prevalence. These approaches are not very welcome in France as our country has developed a "Classification francaise" for child and adolescent mental disorders where the concept of psychosis is kept including bordeline states. Its purpose is to support different ways of psychopathological organisation and many French psychiatrists reserve the diagnostic of autism to a limited number of clinical cases. New versions in 2002 and 2010 tend to be better aligned with the international classifications but do not resolve the lack of agreeement according to the understanding of the etiologies and disorders due to a position where the nosographic debate is subordinated to more confusing psychopathologic considerations. For the future, a "double-diagnostic" for each case may be used (its etiology, its phenotype PDD) together with an increased attention to the dimensional approach of each individual profile, which has become possible as a result of advances in clinical methods. (C) 2012 Elsevier Masson SAS. All rights reserved.
EM domsauvage@wanadoo.fr
CR Bettelheim B, 1950, LOVE IS NOT ENOUGH
Brauner A, 1986, ENFANT DEREEL
Bursztejn C, 2011, ANN MED-PSYCHOL, V169, P256, DOI 10.1016/j.amp.2011.03.011
DSM-5, 2010, LANCET, V276, P390
Hochmann J, 2008, AUTISME
Hochmann J, 1974, TRAITEMENT LONG COUR, P401
Houzel D, 1994, AUTISME CINQUANTE AN, P69
Kanner L, 1945, CHILD PSYCHIAT, P17
Lame T, 1990, J INT MED, V157, P46
Lenoir P, 2009, ENCEPHALE, V35, P36, DOI 10.1016/j.encep.2007.12.011
Levy SE, 2009, LANCET, V374, P1627, DOI 10.1016/S0140-6736(09)61376-3
Mac Milian MB, 1960, AM J PSYCHIAT, V116, P1093
Seguin E, 1997, COMITE HIST SECURITE, V22, P99
Skuse D, 2004, J AM ACAD CHILD PSY, V43, P548, DOI 10.1097/00004583-200405000-00008
NR 14
TC 0
Z9 0
PU MASSON EDITEUR
PI MOULINEAUX CEDEX 9
PA 21 STREET CAMILLE DESMOULINS, ISSY, 92789 MOULINEAUX CEDEX 9, FRANCE
SN 0003-4487
J9 ANN MED-PSYCHOL
JI Ann. Med.-Psychol.
PD SEP
PY 2012
VL 170
IS 7
BP 510
EP 516
DI 10.1016/j.amp.2012.06.018
PG 7
WC Pharmacology & Pharmacy; Psychiatry; Psychology; Psychology,
Multidisciplinary
SC Pharmacology & Pharmacy; Psychiatry; Psychology
GA 025KE
UT WOS:000310187000020
ER
PT J
AU Cohen, D
AF Cohen, David
TI Recent controversies in Autism Spectrum Disorder
SO ANNALES MEDICO-PSYCHOLOGIQUES
LA French
DT Article
DE Autism; Controversies; Early diagnosis; Etiopathology; Prevalence
ID DEVELOPMENTAL DISORDERS; RISK-FACTORS
AB Autism is a clinical syndrome whose description so characteristic participated in the foundation of child psychiatry. Yet, it remains the syndrome of all mysteries and all controversies. The first controversy was taken up by the working group of DSM-V, for precisely the clinical definition and broadening of the spectrum of autism. Motivations of various kinds appear to justify the spectrum view. We will question them from research on Multiplex Developmental Disorder or disharmonies, since these are concepts at the border of the spectrum. A second controversy regards its origin, recognizing that current research emphasizes and revisits the genetic causes from paper to paper. Without ignoring the importance of genetic factors, we will explore the environmental factors involved and propose a developmental model based on probabilistic multifactor perspective better able to explain the possible increase in prevalence. This is the third a controversy. Are we confronted to a real increase in the prevalence of autism spectrum disorders? Is it only a broader definition and a more systematic tracking of cases? Yet, another controversy regards the age at which the diagnosis of autism can be performed early. We will discuss this point from research focusing on the parent-infant early interaction and show that parents of infants, who will later develop autism, are significantly more often actively seeking answers from their baby, as young as 6 months. Finally, we will conclude with the controversy regarding therapeutic approaches and the methods to be recommended. If we recognize that only behavioral or educational methods have been assessed in controlled studies, it appears a consensus to promote intensive care at the earliest possible age, in a report for one to one, with maximum integration mainstream and involving parents actively. (C) 2012 Published by Elsevier Masson SAS.
C1 [Cohen, David] Univ Paris 06, Grp Hosp Pitie Salpetriere, AP HP, Serv Psychiat Enfant & Adolescent, F-75013 Paris, France.
[Cohen, David] Univ Paris 06, Inst Syst Intelligents & Robot, CNRS UMR 7222, F-75005 Paris, France.
RP Cohen, D (reprint author), Univ Paris 06, Grp Hosp Pitie Salpetriere, AP HP, Serv Psychiat Enfant & Adolescent, 47 Blvd Hop, F-75013 Paris, France.
EM david.cohen@psl.aphp.fr
CR Abrahams BS, 2008, NAT REV GENET, V9, P341, DOI 10.1038/nrg2346
Cohen D, 2005, J AUTISM DEV DISORD, V35, P103, DOI 10.1007/s10803-004-1038-2
Cohen D. J., 1987, HDB AUTISM PERVASIVE, P20
Demouy J, 2011, RES AUTISM SPECT DIS, V5, P1402, DOI 10.1016/j.rasd.2011.01.026
Fombonne Eric, 2009, Mcgill J Med, V12, P73
Gardener H, 2009, BRIT J PSYCHIAT, V195, P7, DOI 10.1192/bjp.bp.108.051672
Gibello B, 2010, NEUROPSYCHIAT ENFAN, V58, P201
Guinchat V, 2012, RES AUTISM SPECT DIS, V6, P589, DOI 10.1016/j.rasd.2011.10.005
Guinchat V, 2012, ACTA OBSTET GYN SCAN, V91, P287, DOI 10.1111/j.1600-0412.2011.01325.x
Hallmayer J, 2011, ARCH GEN PSYCHIAT, V68, P1095, DOI 10.1001/archgenpsychiatry.2011.76
Jones CRG, 2011, J CHILD PSYCHOL PSYC, V52, P275, DOI 10.1111/j.1469-7610.2010.02328.x
Leroy A, 2010, NEUROPSYCHIAT ENFAN, V58, P152
Liebaert F, 2012, USE COMMON GENETICS
Mises R, 2011, ANN MED-PSYCHOL, V169, P248, DOI 10.1016/j.amp.2011.03.006
Ospina MB, 2008, PLOS ONE, V3, DOI 10.1371/journal.pone.0003755
Périsse Didier, 2010, J Can Acad Child Adolesc Psychiatry, V19, P100
Ringeval F, 2011, IEEE T AUDIO SPEECH, V19, P1328, DOI 10.1109/TASL.2010.2090147
Rondeau E, 2011, J AUTISM DEV DISORD, V41, P1267, DOI 10.1007/s10803-010-1155-z
Saint-Georges C, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0022393
Saint-Georges C, 2010, RES AUTISM SPECT DIS, V4, P355, DOI 10.1016/j.rasd.2009.10.017
Tordjman S, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0030778
Tordjman S, 1997, PSYCHIAT ENFANT, V40, P473
Vannetzel L, 2011, RES AUTISM SPECT DIS, V5, P775, DOI 10.1016/j.rasd.2010.09.005
Waters H, 2011, NAT MED, V17, P1336, DOI 10.1038/nm1111-1336
Weintraub K, 2011, NATURE, V479, P22, DOI 10.1038/479022a
Xavier J, 2011, RES AUTISM SPECT DIS, V5, P1493, DOI 10.1016/j.rasd.2011.02.010
NR 26
TC 2
Z9 2
PU MASSON EDITEUR
PI MOULINEAUX CEDEX 9
PA 21 STREET CAMILLE DESMOULINS, ISSY, 92789 MOULINEAUX CEDEX 9, FRANCE
SN 0003-4487
J9 ANN MED-PSYCHOL
JI Ann. Med.-Psychol.
PD SEP
PY 2012
VL 170
IS 7
BP 517
EP 525
DI 10.1016/j.amp.2012.06.019
PG 9
WC Pharmacology & Pharmacy; Psychiatry; Psychology; Psychology,
Multidisciplinary
SC Pharmacology & Pharmacy; Psychiatry; Psychology
GA 025KE
UT WOS:000310187000021
ER
PT J
AU Burstyn, I
Lee, B
Gidaya, NB
Yudell, M
AF Burstyn, Igor
Lee, Brian
Gidaya, Nicole B.
Yudell, Michael
TI Presentation of Study Results: The Authors' Responsibility
SO ENVIRONMENTAL HEALTH PERSPECTIVES
LA English
DT Letter
ID AUTISM SPECTRUM DISORDERS; SOCIOECONOMIC-STATUS; MATERNAL SMOKING;
PREVALENCE; PREGNANCY
C1 [Burstyn, Igor; Lee, Brian; Gidaya, Nicole B.; Yudell, Michael] Drexel Univ, Philadelphia, PA 19104 USA.
RP Burstyn, I (reprint author), Drexel Univ, Philadelphia, PA 19104 USA.
EM igor.burstyn@drexel.edu
CR Adam T, 2011, MEASUREMENT NEUTRINO
[Anonymous], 2012, UWM NEWS
Bodnar LM, 2010, OBESITY, V18, P2184, DOI 10.1038/oby.2010.25
Goodwin J, 2012, PRENATAL SMOKING LIN
Jurek AM, 2006, EUR J EPIDEMIOL, V21, P871, DOI 10.1007/s10654-006-9083-0
Kalkbrenner AE, 2012, ENVIRON HEALTH PERSP, V120, P1042, DOI 10.1289/ehp.1104556
Kharrazi M, 1999, PUBLIC HEALTH REP, V114, P60, DOI 10.1093/phr/114.1.60
King MD, 2011, AM SOCIOL REV, V76, P320, DOI 10.1177/0003122411399389
MacLehose RF, 2012, EPIDEMIOLOGY, V23, P151, DOI 10.1097/EDE.0b013e31823b539c
Palmer J, 2011, SPEED OF LIGHT RESUL
Rai D, 2012, J AM ACAD CHILD PSY, V51, P467, DOI 10.1016/j.jaac.2012.02.012
NR 11
TC 1
Z9 1
PU US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE
PI RES TRIANGLE PK
PA NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, PO BOX 12233,
RES TRIANGLE PK, NC 27709-2233 USA
SN 0091-6765
J9 ENVIRON HEALTH PERSP
JI Environ. Health Perspect.
PD SEP
PY 2012
VL 120
IS 9
BP A343
EP A344
DI 10.1289/ehp.1205556
PG 2
WC Environmental Sciences; Public, Environmental & Occupational Health;
Toxicology
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health; Toxicology
GA 005YV
UT WOS:000308786900004
PM 23487836
ER
PT J
AU Arlt, MF
Rajendran, S
Birkeland, SR
Wilson, TE
Glover, TW
AF Arlt, Martin F.
Rajendran, Sountharia
Birkeland, Shanda R.
Wilson, Thomas E.
Glover, Thomas W.
TI De Novo CNV Formation in Mouse Embryonic Stem Cells Occurs in the
Absence of Xrcc4-Dependent Nonhomologous End Joining
SO PLOS GENETICS
LA English
DT Article
ID COPY-NUMBER VARIATION; DOUBLE-STRAND BREAKS; CHROMOSOMAL TRANSLOCATION
FORMATION; AUTISM SPECTRUM DISORDER; HUMAN GENOME; REPLICATIVE STRESS;
DORMANT ORIGINS; EXCESS MCM2-7; FRAGILE SITES; FINE-SCALE
AB Spontaneous copy number variant (CNV) mutations are an important factor in genomic structural variation, genomic disorders, and cancer. A major class of CNVs, termed nonrecurrent CNVs, is thought to arise by nonhomologous DNA repair mechanisms due to the presence of short microhomologies, blunt ends, or short insertions at junctions of normal and de novo pathogenic CNVs, features recapitulated in experimental systems in which CNVs are induced by exogenous replication stress. To test whether the canonical nonhomologous end joining (NHEJ) pathway of double-strand break (DSB) repair is involved in the formation of this class of CNVs, chromosome integrity was monitored in NHEJ-deficient Xrcc4(-/-) mouse embryonic stem (ES) cells following treatment with low doses of aphidicolin, a DNA replicative polymerase inhibitor. Mouse ES cells exhibited replication stress-induced CNV formation in the same manner as human fibroblasts, including the existence of syntenic hotspot regions, such as in the Auts2 and Wwox loci. The frequency and location of spontaneous and aphidicolin-induced CNV formation were not altered by loss of Xrcc4, as would be expected if canonical NHEJ were the predominant pathway of CNV formation. Moreover, de novo CNV junctions displayed a typical pattern of microhomology and blunt end use that did not change in the absence of Xrcc4. A number of complex CNVs were detected in both wild-type and Xrcc4(-/-) cells, including an example of a catastrophic, chromothripsis event. These results establish that nonrecurrent CNVs can be, and frequently are, formed by mechanisms other than Xrcc4-dependent NHEJ.
C1 [Arlt, Martin F.; Rajendran, Sountharia; Wilson, Thomas E.; Glover, Thomas W.] Univ Michigan, Dept Human Genet, Ann Arbor, MI 48109 USA.
[Birkeland, Shanda R.; Wilson, Thomas E.] Univ Michigan, Dept Pathol, Ann Arbor, MI 48109 USA.
RP Arlt, MF (reprint author), Univ Michigan, Dept Human Genet, Ann Arbor, MI 48109 USA.
EM wilsonte@umich.edu; glover@umich.edu
FU March of Dimes Foundation; NIH/NCI [R01-CA102563]
FX This work was supported by a March of Dimes Foundation research grant to
TWG (http://www.marchofdimes.com/research/researchgrants.html) and
NIH/NCI grant R01-CA102563 to TEW (http://www3.cancer.gov/admin/gab/).
The funders had no role in study design, data collection and analysis,
decision to publish, or preparation of the manuscript.
CR Arlt MF, 2011, GENETICS, V187, P675, DOI 10.1534/genetics.110.124776
Arlt MF, 2011, P NATL ACAD SCI USA, V108, P17360, DOI 10.1073/pnas.1109272108
Arlt MF, 2009, AM J HUM GENET, V84, P339, DOI 10.1016/j.ajhg.2009.01.024
Boubakour-Azzouz I, 2008, DNA REPAIR, V7, P149, DOI 10.1016/j.dnarep.2007.09.005
Campbell PJ, 2008, NAT GENET, V40, P722, DOI 10.1038/ng.128
Carvalho CMB, 2011, NAT GENET, V43, P1074, DOI 10.1038/ng.944
Chiang C, 2012, NAT GENET, V44, P390, DOI 10.1038/ng.2202
Christian SL, 2008, BIOL PSYCHIAT, V63, P1111, DOI 10.1016/j.biopsych.2008.01.009
Conrad DF, 2010, NATURE, V464, P704, DOI 10.1038/nature08516
Conrad DF, 2010, NAT GENET, V42, P385, DOI 10.1038/ng.564
Cook EH, 2008, NATURE, V455, P919, DOI 10.1038/nature07458
Daley JM, 2005, MOL CELL BIOL, V25, P896, DOI 10.1128/MCB.25.3.896-906.2005
Durkin SG, 2008, P NATL ACAD SCI USA, V105, P246, DOI 10.1073/pnas.0708097105
Egan CM, 2007, NAT GENET, V39, P1384, DOI 10.1038/ng.2007.19
Gao YJ, 1998, CELL, V95, P891, DOI 10.1016/S0092-8674(00)81714-6
Ge XQ, 2007, GENE DEV, V21, P3331, DOI 10.1101/gad.457807
Hastings PJ, 2009, PLOS GENET, V5, DOI 10.1371/journal.pgen.1000327
Hastings PJ, 2009, NAT REV GENET, V10, P551, DOI 10.1038/nrg2593
Iafrate AJ, 2004, NAT GENET, V36, P949, DOI 10.1038/ng1416
Inoue K, 2002, AM J HUM GENET, V71, P838, DOI 10.1086/342728
Itsara A, 2010, GENOME RES
Kirov G, 2009, HUM MOL GENET, V18, P1497, DOI 10.1093/hmg/ddp043
Kloosterman WP, 2011, HUM MOL GENET, V20, P1916, DOI 10.1093/hmg/ddr073
Krishnamoorthy K, 2004, J STAT PLAN INFER, V119, P23, DOI 10.1016/S0378-3758(02)00408-1
Le Tallec B, 2011, NAT STRUCT MOL BIOL
Lee JA, 2007, CELL, V131, P1235, DOI 10.1016/j.cell.2007.11.037
Letessier A, 2011, NATURE, V470, P120, DOI 10.1038/nature09745
Liu PF, 2011, CELL, V146, P888, DOI 10.1016/j.cell.2011.07.042
Liu P, 2012, CURR OPIN GENET DEV
Lowden MR, 2011, SCIENCE, V332, P468, DOI 10.1126/science.1199022
Luo Y, 2011, HUM MOL GENET, V20, P3769, DOI 10.1093/hmg/ddr293
Lupski JR, 2007, NAT GENET, V39, pS43, DOI 10.1038/ng2084
Mahaney BL, 2009, BIOCHEM J, V417, P639, DOI 10.1042/BJ20080413
Marshall CR, 2008, AM J HUM GENET, V82, P477, DOI 10.1016/j.ajhg.2007.12.009
McVey M, 2008, TRENDS GENET, V24, P529, DOI 10.1016/j.tig.2008.08.007
Mills RE, 2011, NATURE, V470, P59, DOI 10.1038/nature09708
Mrasek K, 2010, INT J ONCOL, V36, P929, DOI 10.3892/ijo_00000572
Ozeri-Galai E, 2011, MOL CELL, V43, P122, DOI 10.1016/j.molcel.2011.05.019
Palakodeti A, 2004, GENE CHROMOSOME CANC, V39, P71, DOI 10.1002/gcc.10290
Perry GH, 2008, AM J HUM GENET, V82, P685, DOI 10.1016/j.ajhg.2007.12.010
Redon R, 2006, NATURE, V444, P444, DOI 10.1038/nature05329
Sebat J, 2007, SCIENCE, V316, P445, DOI 10.1126/science.1138659
Sebat J, 2004, SCIENCE, V305, P525, DOI 10.1126/science.1098918
Sharp AJ, 2005, AM J HUM GENET, V77, P78, DOI 10.1086/431652
Shaw CJ, 2005, HUM GENET, V116, P1, DOI 10.1007/s00439-004-1204-9
Simsek D, 2010, NAT STRUCT MOL BIOL, V17, P410, DOI 10.1038/nsmb.1773
Simsek D, 2011, PLOS GENET, V7, DOI 10.1371/journal.pgen.1002080
Stankiewicz P, 2007, CURR OPIN GENET DEV, V17, P182, DOI 10.1016/j.gde.2007.04.009
Stankiewicz P, 2003, COLD SPRING HARB SYM, V68, P445, DOI 10.1101/sqb.2003.68.445
Stephens PJ, 2009, NATURE, V462, P1005, DOI 10.1038/nature08645
Stephens PJ, 2011, CELL, V144, P27, DOI 10.1016/j.cell.2010.11.055
Talkowski ME, 2012, CELL, V149, DOI 10.1016/j.cell.2012.03.028
Tam GWC, 2009, BIOL PSYCHIAT, V66, P1005, DOI 10.1016/j.biopsych.2009.07.027
Toffolatti L, 2002, GENOMICS, V80, P523, DOI 10.1006/geno.2002.6861
Woodward AM, 2006, J CELL BIOL, V173, P673, DOI 10.1083/jcb.200602108
Woodward KJ, 2005, AM J HUM GENET, V77, P966, DOI 10.1086/498048
Yalcin B, 2012, GENOME BIOL, V13, DOI 10.1186/gb-2012-13-3-r18
Yan CT, 2007, NATURE, V449, P478, DOI 10.1038/nature06020
Zhang F, 2009, ANNU REV GENOM HUM G, V10, P451, DOI 10.1146/annurev.genom.9.081307.164217
Zhang Y, 2011, NAT STRUCT MOL BIOL, V18, P80, DOI 10.1038/nsmb.1940
NR 60
TC 17
Z9 17
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1553-7404
J9 PLOS GENET
JI PLoS Genet.
PD SEP
PY 2012
VL 8
IS 9
AR e1002981
DI 10.1371/journal.pgen.1002981
PG 12
WC Genetics & Heredity
SC Genetics & Heredity
GA 020NK
UT WOS:000309817900044
PM 23028374
ER
PT J
AU Khanna, R
Jariwala, K
AF Khanna, Rahul
Jariwala, Krutika
TI Awareness and knowledge of autism among pharmacists
SO RESEARCH IN SOCIAL & ADMINISTRATIVE PHARMACY
LA English
DT Article
DE Pharmacists; Autism; Awareness; Knowledge
ID PSYCHOTROPIC MEDICATION USE; SPECTRUM DISORDERS; RUBELLA VACCINE;
UNITED-STATES; RESPONSE RATE; MAIL SURVEYS; CHILDREN; TIME; MEASLES;
MUMPS
AB Background: In the past few decades, the prevalence of autism has increased tremendously in the United States. The prevalence of autism is now higher than the combined prevalence of juvenile diabetes, pediatric cancer, and pediatric AIDS. As health care professionals with a high visibility in a community, pharmacists are likely to encounter more and more families having a child affected by this disorder.
Objectives: The purpose of this study was to assess pharmacists' awareness and knowledge of autism. The study aimed to assess pharmacists' familiarity with autism symptoms, treatment medications, and community resources devoted to this disorder. Further, pharmacists' knowledge of common myths associated with autism, etiology, prognosis, and treatment were assessed.
Methods: Using a cross-sectional design, an online survey of pharmacists registered in the state of Mississippi (MS) was conducted, using the Qualtrics software program. Descriptive analysis of study items was conducted.
Results: A total of 147 usable responses (5.8%) were received. The results indicated gaps in pharmacists' awareness and knowledge of autism. Approximately, 23% of pharmacists did not know that autism is a developmental disorder, and 32% did not believe that genetics has a major role in autism etiology. More than 18% believed that vaccines can cause autism. Most (> 90%) felt that they could benefit from autism continuing education (CE).
Conclusion: Policy makers and autism agencies should consider providing educational interventions or CE programs to increase pharmacists' awareness and knowledge of autism. (C) 2012 Elsevier Inc. All rights reserved.
C1 [Khanna, Rahul; Jariwala, Krutika] Univ Mississippi, Sch Pharm, Dept Pharm Adm, University, MS 38677 USA.
RP Khanna, R (reprint author), Univ Mississippi, Sch Pharm, Dept Pharm Adm, Faser Hall,Room 236,POB 1848, University, MS 38677 USA.
EM rkhanna@olemiss.edu
CR Aman MG, 2005, J CLIN PSYCHIAT, V66, P38
American Psychiatric Association, 2000, DIAGN STAT MAN MENT
Andreson SE, 1995, SOC SCI COMPUT REV, V13, P33
[Anonymous], 2010, LANCET, V375, P445
Autism Speaks, WHAT IS AUT
Bickart B, 1999, J MARKETING RES, V36, P286, DOI 10.2307/3152100
Centers for Disease Control and Prevention, 2009, MMWR-MORBID MORTAL W, V58, P1
Cobanoglu C, 2003, INT J MARKET RES, V45, P475
Dales L, 2001, JAMA-J AM MED ASSOC, V285, P1183, DOI 10.1001/jama.285.9.1183
Esbensen AJ, 2009, J AUTISM DEV DISORD, V39, P1339, DOI 10.1007/s10803-009-0750-3
Freeman BJ, 1997, J AUTISM DEV DISORD, V27, P641, DOI 10.1023/A:1025850715183
Hertz-Picciotto I, 2006, ENVIRON HEALTH PERSP, V114, P1119, DOI 10.1289/ehp.8483
Jones R, 1999, OCCUP MED-OXFORD, V49, P556, DOI 10.1093/occmed/49.8.556
Kaye JA, 2001, BRIT MED J, V322, P460, DOI 10.1136/bmj.322.7284.460
Keenan Nora L., 2011, Morbidity and Mortality Weekly Report, V60, P94
KITTLESON MJ, 1995, HEALTH VAL, V19, P27
Leung AKC, 1999, AM FAM PHYSICIAN, V59, P3121
Mandell DS, 2008, PEDIATRICS, V121, pE441, DOI 10.1542/peds.2007-0984
Matson JL, 2011, RES AUTISM SPECT DIS, V5, P230, DOI 10.1016/j.rasd.2010.04.004
Mrozek-Budzyn D, 2010, PEDIATR INFECT DIS J, V29, P397, DOI 10.1097/INF.0b013e3181c40a8a
National Committee for Quality Assurance (NCQA), 2010, STAT HLTH CAR QUAL 2
Rice C, 2010, DISABIL HEALTH J, V3, P186, DOI 10.1016/j.dhjo.2009.10.008
Rubin DM, 2009, PEDIATRICS, V124, pE305, DOI 10.1542/peds.2008-3713
Schwartz H, 2008, LANG SPEECH HEAR SER, V39, P66, DOI 10.1044/0161-1461(2008/007)
Shannon DM, 2002, J EXP EDUC, V70, P179
Sheehan K. B., 2001, J COMPUTER MEDIATED, P6
Sheehan KB, 1999, J ADVERTISING RES, V39, P45
Shih TH, 2008, FIELD METHOD, V20, P249, DOI 10.1177/1525822X08317085
Strunk JA, 2009, J SCH NURS, V25, P445, DOI 10.1177/1059840509348221
Taylor B, 1999, LANCET, V353, P2026, DOI 10.1016/S0140-6736(99)01239-8
Tsai LY, 1999, PSYCHOSOM MED, V61, P651
Wakefield AJ, 1998, LANCET, V351, P637, DOI 10.1016/S0140-6736(97)11096-0
Wiggins LD, 2006, J DEV BEHAV PEDIATR, V27, pS79, DOI 10.1097/00004703-200604002-00005
NR 33
TC 0
Z9 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1551-7411
J9 RES SOC ADMIN PHARM
JI Res. Soc. Adm. Pharm.
PD SEP-OCT
PY 2012
VL 8
IS 5
BP 464
EP 471
DI 10.1016/j.sapharm.2011.11.002
PG 8
WC Public, Environmental & Occupational Health; Pharmacology & Pharmacy
SC Public, Environmental & Occupational Health; Pharmacology & Pharmacy
GA 017YP
UT WOS:000309627400012
PM 22222344
ER
PT J
AU Langlitz, N
AF Langlitz, Nicolas
TI Autism: Pioneers, parents and the proliferation of a diagnosis
SO BIOSOCIETIES
LA English
DT Editorial Material
C1 New Sch Social Res, Dept Anthropol, New York, NY 10011 USA.
RP Langlitz, N (reprint author), New Sch Social Res, Dept Anthropol, New York, NY 10011 USA.
EM LanglitN@newschool.edu
CR Lakoff A, 2012, PUBLIC CULTURE, V24, P217, DOI 10.1215/08992363-1443610
Hacking I., 2007, P BRIT ACAD, V151, P285, DOI DOI 10.5871/BACAD/9780197264249.003.0010
LANGLITZ N, AUSTISM PIONEERS PAR
NR 3
TC 0
Z9 0
PU PALGRAVE MACMILLAN LTD
PI BASINGSTOKE
PA BRUNEL RD BLDG, HOUNDMILLS, BASINGSTOKE RG21 6XS, HANTS, ENGLAND
SN 1745-8552
J9 BIOSOCIETIES
JI BioSocieties
PD SEP
PY 2012
VL 7
IS 3
BP 322
EP 323
DI 10.1057/biosoc.2012.16
PG 2
WC Social Sciences, Biomedical
SC Biomedical Social Sciences
GA 017UK
UT WOS:000309616300007
ER
PT J
AU Hacking, I
AF Hacking, Ian
TI Understanding Autism: Parents, Doctors, and the History of a Disorder
SO BIOSOCIETIES
LA English
DT Book Review
C1 [Hacking, Ian] Coll France, F-75231 Paris, France.
[Hacking, Ian] Univ Toronto, Toronto, ON M5S 1A1, Canada.
RP Hacking, I (reprint author), Coll France, F-75231 Paris, France.
CR SILVERMAN C, 2010, UNDERSTANDING AUTISM
NR 1
TC 0
Z9 0
PU PALGRAVE MACMILLAN LTD
PI BASINGSTOKE
PA BRUNEL RD BLDG, HOUNDMILLS, BASINGSTOKE RG21 6XS, HANTS, ENGLAND
SN 1745-8552
J9 BIOSOCIETIES
JI BioSocieties
PD SEP
PY 2012
VL 7
IS 3
BP 323
EP 326
PG 4
WC Social Sciences, Biomedical
SC Biomedical Social Sciences
GA 017UK
UT WOS:000309616300009
ER
PT J
AU Hacking, I
AF Hacking, Ian
TI A History of Autism: Conversations with the Pioneers
SO BIOSOCIETIES
LA English
DT Book Review
C1 [Hacking, Ian] Coll France, F-75231 Paris, France.
[Hacking, Ian] Univ Toronto, Toronto, ON M5S 1A1, Canada.
RP Hacking, I (reprint author), Coll France, F-75231 Paris, France.
CR Feinstein Adam, 2010, HIST AUTISM CONVERSA
NR 1
TC 0
Z9 0
PU PALGRAVE MACMILLAN LTD
PI BASINGSTOKE
PA BRUNEL RD BLDG, HOUNDMILLS, BASINGSTOKE RG21 6XS, HANTS, ENGLAND
SN 1745-8552
J9 BIOSOCIETIES
JI BioSocieties
PD SEP
PY 2012
VL 7
IS 3
BP 323
EP 326
PG 4
WC Social Sciences, Biomedical
SC Biomedical Social Sciences
GA 017UK
UT WOS:000309616300008
ER
PT J
AU Epstein, S
AF Epstein, Steven
TI The Autism Matrix
SO BIOSOCIETIES
LA English
DT Book Review
C1 [Epstein, Steven] Northwestern Univ, Dept Sociol, Evanston, IL 60208 USA.
RP Epstein, S (reprint author), Northwestern Univ, Dept Sociol, Evanston, IL 60208 USA.
CR Epstein Steven, 1996, IMPURE SCI AIDS ACTI
Eyal G., 2010, AUTISM MATRIX
Hacking Ian, 1986, RECONSTRUCTING INDIV, P222
Ong-Dean Colin, 2009, DISTINGUISHING DISAB
NR 4
TC 0
Z9 0
PU PALGRAVE MACMILLAN LTD
PI BASINGSTOKE
PA BRUNEL RD BLDG, HOUNDMILLS, BASINGSTOKE RG21 6XS, HANTS, ENGLAND
SN 1745-8552
J9 BIOSOCIETIES
JI BioSocieties
PD SEP
PY 2012
VL 7
IS 3
BP 327
EP 329
DI 10.1057/biosoc.2012.15
PG 3
WC Social Sciences, Biomedical
SC Biomedical Social Sciences
GA 017UK
UT WOS:000309616300010
ER
PT J
AU Timmermans, S
AF Timmermans, Stefan
TI The Autism Matrix
SO BIOSOCIETIES
LA English
DT Book Review
C1 [Timmermans, Stefan] Univ Calif Los Angeles, Dept Sociol, Los Angeles, CA 90024 USA.
RP Timmermans, S (reprint author), Univ Calif Los Angeles, Dept Sociol, Los Angeles, CA 90024 USA.
CR Berrington L, 2012, DAILY BEAST
Callon M, 2008, SCI TECHNOL HUM VAL, V33, P230, DOI 10.1177/0162243907311264
Epstein Steven, 1996, IMPURE SCI AIDS ACTI
Evans R, 2007, RETHINKING EXPERTISE
Eyal G., 2010, AUTISM MATRIX
Hacking Ian, 1986, RECONSTRUCTING INDIV, P222
Hacking Ian, 1999, SOCIAL CONSTRUCTION
Lakoff A, 2005, CAMB STUD SOC LIFE S, P1, DOI 10.2277/ 0521546664
NR 8
TC 0
Z9 0
PU PALGRAVE MACMILLAN LTD
PI BASINGSTOKE
PA BRUNEL RD BLDG, HOUNDMILLS, BASINGSTOKE RG21 6XS, HANTS, ENGLAND
SN 1745-8552
J9 BIOSOCIETIES
JI BioSocieties
PD SEP
PY 2012
VL 7
IS 3
BP 329
EP 331
DI 10.1057/biosoc.2012.17
PG 3
WC Social Sciences, Biomedical
SC Biomedical Social Sciences
GA 017UK
UT WOS:000309616300011
ER
PT J
AU Lakoff, A
AF Lakoff, Andrew
TI The Autism Matrix
SO BIOSOCIETIES
LA English
DT Book Review
C1 [Lakoff, Andrew] Univ So Calif, Dept Anthropol, Los Angeles, CA 90089 USA.
[Lakoff, Andrew] Univ So Calif, Dept Sociol, Los Angeles, CA 90089 USA.
[Lakoff, Andrew] Univ So Calif, Dept Commun, Los Angeles, CA 90089 USA.
RP Lakoff, A (reprint author), Univ So Calif, Dept Anthropol, Los Angeles, CA 90089 USA.
CR Carey Benedict, 2012, NY TIMES
Eyal G., 2010, AUTISM MATRIX
Hacking Ian, 1995, REWRITING SOUL MULTI
Hacking Ian, 1999, SOCIAL CONSTRUCTION
Lakoff A, 2000, J HIST BEHAV SCI, V36, P149, DOI 10.1002/(SICI)1520-6696(200021)36:2<149::AID-JHBS3>3.0.CO;2-9
Young A, 1996, HARMONY ILLUSIONS IN
NR 6
TC 0
Z9 0
PU PALGRAVE MACMILLAN LTD
PI BASINGSTOKE
PA BRUNEL RD BLDG, HOUNDMILLS, BASINGSTOKE RG21 6XS, HANTS, ENGLAND
SN 1745-8552
J9 BIOSOCIETIES
JI BioSocieties
PD SEP
PY 2012
VL 7
IS 3
BP 331
EP 333
DI 10.1057/biosoc.2012.14
PG 3
WC Social Sciences, Biomedical
SC Biomedical Social Sciences
GA 017UK
UT WOS:000309616300012
ER
PT J
AU Addison, LR
Piazza, CC
Patel, MR
Bachmeyer, MH
Rivas, KM
Milnes, SM
Oddo, J
AF Addison, Laura R.
Piazza, Cathleen C.
Patel, Meeta R.
Bachmeyer, Melanie H.
Rivas, Kristi M.
Milnes, Suzanne M.
Oddo, Jackie
TI A COMPARISON OF SENSORY INTEGRATIVE AND BEHAVIORAL THERAPIES AS
TREATMENT FOR PEDIATRIC FEEDING DISORDERS
SO JOURNAL OF APPLIED BEHAVIOR ANALYSIS
LA English
DT Article
DE escape extinction; food refusal; food selectivity; feeding disorders;
noncontingent reinforcement; pediatric feeding disorders; sensory
integration
ID INAPPROPRIATE MEALTIME BEHAVIOR; OCCUPATIONAL-THERAPY; FOOD REFUSAL;
FUNCTIONAL-ANALYSIS; ESCAPE EXTINCTION; CHILDREN; INTERVENTIONS;
REINFORCEMENT; AUTISM; DISABILITIES
AB We compared the effects of escape extinction (EE) plus noncontingent reinforcement (NCR) with sensory integration therapy as treatment for the feeding problems of 2 children. Results indicated that EE plus NCR was more effective in increasing acceptance, decreasing inappropriate behavior, and increasing amount consumed relative to sensory integration for both children. The results are discussed in terms of the challenges of evaluating sensory-integration-based treatments, and the reasons why component analyses of multicomponent treatments like sensory integration are important.
C1 [Piazza, Cathleen C.; Rivas, Kristi M.; Milnes, Suzanne M.] Univ Nebraska Med Ctr, Munroe Meyer Inst, Omaha, NE USA.
[Addison, Laura R.] Addison Behav Resources, Camarillo, CA USA.
[Patel, Meeta R.] Clin 4 Kidz, Sausalito, CA USA.
[Oddo, Jackie] Atlanta Speech Sch, Atlanta, GA USA.
RP Piazza, CC (reprint author), Univ Nebraska Med Ctr, Munroe Meyer Inst, Omaha, NE USA.
EM cpiazza@unmc.edu
CR Ahearn WH, 1996, J APPL BEHAV ANAL, V29, P321, DOI 10.1901/jaba.1996.29-321
AYRES AJ, 1972, J LEARN DISABIL, V5, P338
Ayres AJ, 1974, DEV SENSORY INTEGRAT
Bachmeyer MH, 2009, J APPL BEHAV ANAL, V42, P641, DOI 10.1901/jaba.2009.42-641
Baranek GT, 2002, J AUTISM DEV DISORD, V32, P397, DOI 10.1023/A:1020541906063
Borrero CSW, 2010, J APPL BEHAV ANAL, V43, P71, DOI 10.1901/jaba.2010.43-71
Brown T., 2005, OCCUPATIONAL THERAPY, V12, P137, DOI DOI 10.1002/OTI.2
Caretto V, 2000, AM J OCCUP THER, V54, P59, DOI 10.5014/ajot.54.1.59
Case-Smith J., 2005, OCCUPATIONAL THERAPY, P481
Case-Smith J, 2008, AM J OCCUP THER, V62, P416
Case-Smith J, 1999, AM J OCCUP THER, V53, P506
Cermak S. A., 2006, TREATMENT LANGUAGE D, P435
Cermak S. A., 2001, UNDERSTANDING NATURE, P385
COOPER LJ, 1995, J APPL BEHAV ANAL, V28, P139, DOI 10.1901/jaba.1995.28-139
DeGangi G., 1996, BRIT J OCCUPATIONAL, V59, P457
Di Lorenzo C, 2005, J PEDIATR GASTR NUTR, V40, P249, DOI 10.1097/01.MPG.0000154661.39488.AC
FISHER W, 1992, J APPL BEHAV ANAL, V25, P491, DOI 10.1901/jaba.1992.25-491
Girolami PA, 2001, EDUC TRAIN MENT RET, V36, P207
Glass R., 1998, PEDIAT OCCUPATIONAL, P127
Gresham FM, 1999, SCHOOL PSYCHOL REV, V28, P559
HOEHN TP, 1994, J LEARN DISABIL, V27, P338
HUMPHRIES T, 1990, Physical and Occupational Therapy in Pediatrics, V10, P1
Kerwin ME, 1999, J PEDIATR PSYCHOL, V24, P193, DOI 10.1093/jpepsy/24.3.193
Kimball J., 1999, FRAMES REFERENCE PED, P169
Kimball JG, 2007, AM J OCCUP THER, V61, P406
Koomar J. A., 2002, SENSORY INTEGRATION, P261
Lalli JS, 1999, J APPL BEHAV ANAL, V32, P285, DOI 10.1901/jaba.1999.32-285
Lane S. J., 2008, NEURODEVELOPMENTAL D, V1, P673
LaRue RH, 2011, J APPL BEHAV ANAL, V44, P719, DOI 10.1901/jaba.2011.44-719
Mailloux Z, 2004, AUTISM COMPREHENSIVE, P215
MASON SA, 1990, J APPL BEHAV ANAL, V23, P361, DOI 10.1901/jaba.1990.23-361
May-Benson TA, 2010, AM J OCCUP THER, V64, P403, DOI 10.5014/ajot.2010.09071
Najdowski AC, 2008, J APPL BEHAV ANAL, V41, P459, DOI 10.1901/jaba.2008.41-459
Parham D. L., 2005, OCCUPATIONAL THERAPY, P356
Parham LD, 2007, AM J OCCUP THER, V61, P216
Piazza CC, 2003, J APPL BEHAV ANAL, V36, P309, DOI 10.1901/jaba.2003.36-309
Piazza CC, 2003, J APPL BEHAV ANAL, V36, P187, DOI 10.1901/jaba.2003.36-187
Pruzansky C., 1999, FRAMES REFERENCES PE, P589
Reed GK, 2004, J APPL BEHAV ANAL, V37, P27, DOI 10.1901/jaba.2004.37-27
Roane HS, 1998, J APPL BEHAV ANAL, V31, P605, DOI 10.1901/jaba.1998.31-605
Roley S.S., 2001, UNDERSTANDING NATURE, P313
Royeen C. B., 1991, SENSORY INTEGRATION, P108
Schaaf RC, 2005, MENT RETARD DEV D R, V11, P143, DOI 10.1002/mrdd.20067
Schechtman M. A., 2007, PSYCHIAT ANN, V37, P630
Storch BA, 1996, AM J OCCUP THER, V50, P662
Tarbell MC, 2002, INFANT YOUNG CHILD, V15, P29
Volkert V. M., 2012, HDB EVIDENCE BASED P, V1, P456
Watling R, 1999, AM J OCCUP THER, V53, P498
Wilbarger P., 1991, SENSORY DEFENSIVENES
Wilbarger P., 1984, ZERO 3, P7
Williamson G. G., 1997, ZERO 3, V17, P29
Yack E., 2002, BUILDING BRIDGES SEN
NR 52
TC 4
Z9 4
PU JOURNAL APPL BEHAV ANAL
PI LAWRENCE
PA DEPT HUMAN DEVELOPMENT, UNIV KANSAS, LAWRENCE, KS 66045 USA
SN 0021-8855
J9 J APPL BEHAV ANAL
JI J. Appl. Behav. Anal.
PD FAL
PY 2012
VL 45
IS 3
BP 455
EP 471
DI 10.1901/jaba.2012.45-455
PG 17
WC Psychology, Clinical
SC Psychology
GA 020BB
UT WOS:000309782500001
PM 23060661
ER
PT J
AU Leaf, JB
Oppenheim-Leaf, ML
Leaf, R
Courtemanche, AB
Taubman, M
McEachin, J
Sheldon, JB
Sherman, JA
AF Leaf, Justin B.
Oppenheim-Leaf, Misty L.
Leaf, Ronald
Courtemanche, Andrea B.
Taubman, Mitchell
McEachin, John
Sheldon, Jan B.
Sherman, James A.
TI OBSERVATIONAL EFFECTS ON THE PREFERENCES OF CHILDREN WITH AUTISM
SO JOURNAL OF APPLIED BEHAVIOR ANALYSIS
LA English
DT Article
DE autism; conditioned reinforcement; observational learning; preference;
reinforcement
ID RESPONSE-RESTRICTION ANALYSIS; ASPERGERS SYNDROME; CONDITIONED
REINFORCEMENT
AB Children with an autism spectrum disorder (ASD) may play with limited objects or toys, making it difficult for teachers to identify reinforcers to use in teaching new skills. The goal of this study was to alter children's preferences from highly preferred toys to toys that were originally less preferred using-an observational pairing procedure. Child participants observed a preferred adult playing with toys that were initially less preferred by the child. This intervention resulted in a shift in preference toward the item manipulated by the adult. Maintenance of the changed preference was idiosyncratic across participants. Results suggest a procedure for expanding the range of items that students with ASD will select.
C1 [Leaf, Justin B.; Oppenheim-Leaf, Misty L.; Courtemanche, Andrea B.; Sheldon, Jan B.; Sherman, James A.] Univ Kansas, Lawrence, KS 66045 USA.
[Leaf, Justin B.; Leaf, Ronald; Taubman, Mitchell; McEachin, John] Autism Partnership, Seal Beach, CA 90740 USA.
RP Leaf, JB (reprint author), Autism Partnership, 200 Marina Dr, Seal Beach, CA 90740 USA.
EM Jblautpar@aol.com
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
ARENSON SJ, 1976, J PSYCHOL, V94, P65
Bruzek JL, 2007, J APPL BEHAV ANAL, V40, P327, DOI 10.1901/jaba.2007.102-06
Duncker K, 1938, J ABNORM SOC PSYCH, V33, P489, DOI 10.1037/h0056660
FISHER W, 1992, J APPL BEHAV ANAL, V25, P491, DOI 10.1901/jaba.1992.25-491
Greeri RD, 2008, J EXP ANAL BEHAV, V89, P15, DOI 10.1901/jeab.2008.89-15
Greer RD, 2006, INT J PSYCHOL, V41, P486, DOI 10.1080/00207590500492435
Hanley GP, 2003, J APPL BEHAV ANAL, V36, P47, DOI 10.1901/jaba.2003.36-47
Hanley GP, 2003, J APPL BEHAV ANAL, V36, P59, DOI 10.1901/jaba.2003.36-59
KERBESHIAN J, 1990, BRIT J PSYCHIAT, V156, P721, DOI 10.1192/bjp.156.5.721
Singer-Dudek J, 2011, J APPL BEHAV ANAL, V44, P421, DOI 10.1901/jaba.2011.44-421
SZATMARI P, 1989, DEV MED CHILD NEUROL, V31, P709
SZATMARI P, 1989, CAN J PSYCHIAT, V34, P554
SZATMARI P, 1989, J AUTISM DEV DISORD, V19, P213, DOI 10.1007/BF02211842
Tantam D., 1991, AUTISM ASPERGER SYND, P147, DOI 10.1017/CBO9780511526770.005
NR 15
TC 3
Z9 3
PU JOURNAL APPL BEHAV ANAL
PI LAWRENCE
PA DEPT HUMAN DEVELOPMENT, UNIV KANSAS, LAWRENCE, KS 66045 USA
SN 0021-8855
J9 J APPL BEHAV ANAL
JI J. Appl. Behav. Anal.
PD FAL
PY 2012
VL 45
IS 3
BP 473
EP 483
DI 10.1901/jaba.2012.45-473
PG 11
WC Psychology, Clinical
SC Psychology
GA 020BB
UT WOS:000309782500002
PM 23060662
ER
PT J
AU Penrod, B
Gardella, L
Fernand, J
AF Penrod, Becky
Gardella, Laura
Fernand, Jonathan
TI AN EVALUATION OF A PROGRESSIVE HIGH-PROBABILITY INSTRUCTIONAL SEQUENCE
COMBINED WITH LOW-PROBABILITY DEMAND FADING IN THE TREATMENT OF FOOD
SELECTIVITY
SO JOURNAL OF APPLIED BEHAVIOR ANALYSIS
LA English
DT Article
DE food selectivity; noncompliance; high-p instructional sequence; demand
fading
ID ESCAPE EXTINCTION; REFUSAL
AB Few studies have examined the effects of the high-probability instructional sequence in the treatment of food selectivity, and results of these studies have been mixed (e.g., Dawson et al., 2003; Patel et al., 2007). The present study extended previous research on the high-probability instructional sequence by combining this procedure with low-probability demand fading with 2 boys with autism (9 and 10 years old) who had a history of food selectivity and engaged in active food refusal behaviors when presented with novel foods. Response requirements were faded gradually from responses the child would tolerate (e.g., touching the food) to the final requirement of chewing and swallowing the food. The antecedent-based intervention was implemented in the absence of escape extinction and was effective in increasing food consumption for both participants. Possible mechanisms responsible for the effectiveness of the intervention are discussed along with directions for future research.
C1 [Penrod, Becky] Calif State Univ Sacramento, Dept Psychol, Sacramento, CA 95819 USA.
RP Penrod, B (reprint author), Calif State Univ Sacramento, Dept Psychol, 6000 J St, Sacramento, CA 95819 USA.
EM penrodb@csus.edu
CR Ahearn WH, 2001, BEHAV MODIF, V25, P385, DOI 10.1177/0145445501253002
Ahearn WH, 2001, J AUTISM DEV DISORD, V31, P505, DOI 10.1023/A:1012221026124
Bachmeyer Melanie H, 2009, Behav Anal Pract, V2, P43
BUDD KS, 1992, J PEDIATR PSYCHOL, V17, P81, DOI 10.1093/jpepsy/17.1.81
Dawson JE, 2003, J APPL BEHAV ANAL, V36, P105, DOI 10.1901/jaba.2003.36-105
FISHER W, 1992, J APPL BEHAV ANAL, V25, P491, DOI 10.1901/jaba.1992.25-491
Freeman KA, 1998, J APPL BEHAV ANAL, V31, P691, DOI 10.1901/jaba.1998.31-691
Kern L, 1996, J APPL BEHAV ANAL, V29, P243, DOI 10.1901/jaba.1996.29-243
Mace CF, 1988, J APPL BEHAV ANAL, V21, P123
Najdowski AC, 2003, J APPL BEHAV ANAL, V36, P383, DOI 10.1901/jaba.2003.36-383
PACE GM, 1985, J APPL BEHAV ANAL, V18, P249, DOI 10.1901/jaba.1985.18-249
Patel M, 2007, BEHAV INTERVENT, V22, P305, DOI 10.1002/bin.251
Penrod B, 2010, BEHAV INTERVENT, V25, P207, DOI 10.1002/bin.307
NR 13
TC 0
Z9 0
PU JOURNAL APPL BEHAV ANAL
PI LAWRENCE
PA DEPT HUMAN DEVELOPMENT, UNIV KANSAS, LAWRENCE, KS 66045 USA
SN 0021-8855
J9 J APPL BEHAV ANAL
JI J. Appl. Behav. Anal.
PD FAL
PY 2012
VL 45
IS 3
BP 527
EP 537
DI 10.1901/jaba.2012.45-527
PG 11
WC Psychology, Clinical
SC Psychology
GA 020BB
UT WOS:000309782500006
PM 23060666
ER
PT J
AU Marchese, NV
Carr, JE
LeBlanc, LA
Rosati, TC
Conroy, SA
AF Marchese, Nancy V.
Carr, James E.
LeBlanc, Linda A.
Rosati, Tiffany C.
Conroy, Samantha A.
TI THE EFFECTS OF THE QUESTION "WHAT IS THIS?" ON TACT-TRAINING OUTCOMES OF
CHILDREN WITH AUTISM
SO JOURNAL OF APPLIED BEHAVIOR ANALYSIS
LA English
DT Article
DE autism; language training; stimulus control; tacts; verbal behavior
AB Tact training is a common element of many habilitative programs for individuals with developmental disabilities. A commonly recommended practice is to include a supplemental question (e.g., "What is this?") during training trials for tacts of objects. However, the supplemental question is not a defining feature of the tact relation, and prior research suggests that its inclusion might sometimes impede tact acquisition. The present study compared tact training with and without the supplemental question in terms of acquisition and maintenance. Two of 4 children with autism acquired tacts more efficiently in the object-only condition; the remaining 2 children acquired tacts more efficiently in the object + question condition. During maintenance tests in the absence of the supplemental question, all participants emitted tacts at end-of-training levels across conditions with no differential effect observed between training conditions.
C1 [Carr, James E.; LeBlanc, Linda A.] Auburn Univ, Auburn, AL 36849 USA.
RP LeBlanc, LA (reprint author), Trumpet Behav Hlth, 390 Union Blvd,Suite 300, Lakewood, CO 80228 USA.
EM leblanc@tbh.com
CR Braam S. J., 1991, ANAL VERBAL BEHAV, V9, P1
COLEMAN SL, 1974, J BEHAV THER EXP PSY, V5, P275, DOI 10.1016/0005-7916(74)90078-0
DeLeon IG, 1996, J APPL BEHAV ANAL, V29, P519, DOI 10.1901/jaba.1996.29-519
Koehler LJ, 2005, J APPL BEHAV ANAL, V38, P469, DOI 10.1901/jaba.2005.102-04
Leaf R., 1999, WORK PROGR BEHAV MAN
Lovaas O. I., 2003, TEACHING INDIVIDUALS
PARTINGTON JW, 1994, J APPL BEHAV ANAL, V27, P733, DOI 10.1901/jaba.1994.27-733
Skinner B. F., 1957, VERBAL BEHAV
Sundberg M. L., 2008, VERBAL BEHAV MILESTO
Sundberg M L, 2000, Anal Verbal Behav, V17, P89
Sundberg M. L., 1998, TEACHING LANGUAGE CH
Volkert VM, 2008, J APPL BEHAV ANAL, V41, P335, DOI 10.1901/jaba.2008.41-335
Williams G, 2006, J APPL BEHAV ANAL, V39, P233, DOI 10.1901/jaba.2006.175-04
Williams G., 1993, BEHAVIOROLOGY, V1, P31
NR 14
TC 1
Z9 1
PU JOURNAL APPL BEHAV ANAL
PI LAWRENCE
PA DEPT HUMAN DEVELOPMENT, UNIV KANSAS, LAWRENCE, KS 66045 USA
SN 0021-8855
J9 J APPL BEHAV ANAL
JI J. Appl. Behav. Anal.
PD FAL
PY 2012
VL 45
IS 3
BP 539
EP 547
DI 10.1901/jaba.2012.45-539
PG 9
WC Psychology, Clinical
SC Psychology
GA 020BB
UT WOS:000309782500007
PM 23060667
ER
PT J
AU Love, JJ
Miguel, CF
Fernand, JK
LaBrie, JK
AF Love, Jessica J.
Miguel, Caio F.
Fernand, Jonathan K.
LaBrie, Jillian K.
TI THE EFFECTS OF MATCHED STIMULATION AND RESPONSE INTERRUPTION AND
REDIRECTION ON VOCAL STEREOTYPY
SO JOURNAL OF APPLIED BEHAVIOR ANALYSIS
LA English
DT Article
DE autism; matched stimulation; response interruption and redirection;
vocal stereotypy
ID AUTOMATIC REINFORCEMENT; DEVELOPMENTAL-DISABILITIES; ESTABLISHING
OPERATION; CHALLENGING BEHAVIOR; AUTISM; REPLICATION; EXTINCTION;
CHILDREN; BLOCKING; LEISURE
AB Stereotypy has been classified as repetitive behavior that does not serve any apparent function. Two procedures that have been found to reduce rates of vocal stereotypy effectively arc response interruption and redirection (RIRD) and noncontingent access to matched stimulation (MS). The purpose of the current study was to evaluate the effects of RIRD alone, MS alone, and MS combined with RIRD. One participant's results suggested similar suppressive effects on vocal stereotypy across treatment conditions. For the second participant, a slightly greater suppression of stereotypy was associated with MS + RIRD. In addition, both participants emitted a greater frequency of appropriate vocalizations in conditions with RIRD. Data suggest that the addition of MS might facilitate the implementation of RIRD in applied settings.
C1 [Miguel, Caio F.] Calif State Univ Sacramento, Dept Psychol, Sacramento, CA 95819 USA.
RP Miguel, CF (reprint author), Calif State Univ Sacramento, Dept Psychol, 6000 J St, Sacramento, CA 95819 USA.
EM miguelc@csus.edu
CR Ahearn WH, 2005, J APPL BEHAV ANAL, V38, P247, DOI 10.1901/jaba.2005.36-04
Ahearn WH, 2007, J APPL BEHAV ANAL, V40, P263, DOI 10.1901/jaba.2007.30-06
Ahrens EN, 2011, J APPL BEHAV ANAL, V44, P95, DOI 10.1901/jaba.2011.44-95
American Psychiatric Association, 2005, DIAGN STAT MAN MENT
Athens ES, 2008, J APPL BEHAV ANAL, V41, P291, DOI 10.1901/jaba.2008.41-291
DeLeon IG, 1996, J APPL BEHAV ANAL, V29, P519, DOI 10.1901/jaba.1996.29-519
Duffy-Cassella M., 2011, J APPL BEHAV ANAL, V44, P169
DURAND VM, 1987, J APPL BEHAV ANAL, V20, P119, DOI 10.1901/jaba.1987.20-119
Falcomata TS, 2004, J APPL BEHAV ANAL, V37, P83, DOI 10.1901/jaba.2004.37-83
Fisher WW, 1998, J APPL BEHAV ANAL, V31, P513, DOI 10.1901/jaba.1998.31-513
Fisher WW, 1996, AM J MENT RETARD, V101, P15
HOLCOMBE A, 1994, TOP EARLY CHILD SPEC, V14, P119
IWATA BA, 1994, J APPL BEHAV ANAL, V27, P197, DOI 10.1901/jaba.1994.27-197
KOEGEL RL, 1972, J APPL BEHAV ANAL, V5, P381, DOI 10.1901/jaba.1972.5-381
Lanovaz MJ, 2009, BEHAV MODIF, V33, P682, DOI 10.1177/0145445509344972
Lerman DC, 1996, J APPL BEHAV ANAL, V29, P231, DOI 10.1901/jaba.1996.29-231
Lewis MH, 1998, MENT RETARD DEV D R, V4, P80, DOI 10.1002/(SICI)1098-2779(1998)4:2<80::AID-MRDD4>3.0.CO;2-0
Liu-Gitz L, 2010, BEHAV INTERVENT, V25, P77, DOI 10.1002/bin.297
Lovaas O. I., 1987, J APPL BEHAV ANAL, V20, P45
Matson JL, 1997, RES DEV DISABIL, V18, P471, DOI 10.1016/S0891-4222(97)00023-1
Michael J. L., 2003, CONCEPTS PRINCIPLES
Miguel CF, 2009, J APPL BEHAV ANAL, V42, P883, DOI 10.1901/jaba.2009.42-883
Mudford OC, 2009, J APPL BEHAV ANAL, V42, P527, DOI 10.1901/jaba.2009.42-527
O'Reilly M, 2007, BEHAV INTERVENT, V22, P137, DOI 10.1002/bin.226
O'Reilly MF, 2008, RES DEV DISABIL, V29, P333, DOI 10.1016/j.ridd.2007.06.004
O'Reilly MF, 2006, J APPL BEHAV ANAL, V39, P239, DOI 10.1901/jaba.2006.160-04
Piazza CC, 2000, J APPL BEHAV ANAL, V33, P13, DOI 10.1901/jaba.2000.33-13
Piazza CC, 1998, J APPL BEHAV ANAL, V31, P165, DOI 10.1901/jaba.1998.31-165
Rapp JT, 2007, J APPL BEHAV ANAL, V40, P73, DOI 10.1901/jaba.2007.142-05
Rapp JT, 2006, J APPL BEHAV ANAL, V39, P137, DOI 10.1901/jaba.2006.37-05
REPP AC, 1980, J APPL BEHAV ANAL, V13, P333, DOI 10.1901/jaba.1980.13-333
Roscoe EM, 2008, J APPL BEHAV ANAL, V41, P351, DOI 10.1901/jaba.2008.41-351
Smith RG, 1999, J APPL BEHAV ANAL, V32, P367, DOI 10.1901/jaba.1999.32-367
Taylor BA, 2005, BEHAV INTERVENT, V20, P239, DOI 10.1002/bin.200
VOLLMER TR, 1994, RES DEV DISABIL, V15, P187, DOI 10.1016/0891-4222(94)90011-6
NR 35
TC 12
Z9 12
PU JOURNAL APPL BEHAV ANAL
PI LAWRENCE
PA DEPT HUMAN DEVELOPMENT, UNIV KANSAS, LAWRENCE, KS 66045 USA
SN 0021-8855
J9 J APPL BEHAV ANAL
JI J. Appl. Behav. Anal.
PD FAL
PY 2012
VL 45
IS 3
BP 549
EP 564
DI 10.1901/jaba.2012.45-549
PG 16
WC Psychology, Clinical
SC Psychology
GA 020BB
UT WOS:000309782500008
PM 23060668
ER
PT J
AU Fragale, CL
O'Reilly, MF
Aguilar, J
Pierce, N
Lang, R
Sigafoos, J
Lancioni, G
AF Fragale, Christina L.
O'Reilly, Mark F.
Aguilar, Jeannie
Pierce, Nigel
Lang, Russell
Sigafoos, Jeff
Lancioni, Giulio
TI THE INFLUENCE OF MOTIVATING OPERATIONS ON GENERALIZATION PROBES OF
SPECIFIC MANDS BY CHILDREN WITH AUTISM\
SO JOURNAL OF APPLIED BEHAVIOR ANALYSIS
LA English
DT Article
DE mands; motivating operations; generalization; autism
ID CHALLENGING BEHAVIOR; ESTABLISHING OPERATIONS; STEREOTYPY; STIMULI
AB We investigated the influence of motivating operations on the generalization of newly taught mands across settings and communication partners for 3 children with autism. Two conditions were implemented prior to generalization probes. In the first condition, participants were given access to a preferred item until they rejected the item (i.e., abolishing operation). In the second condition, the item was not available to participants prior to generalization probes (i.e., establishing operation). The effects of these conditions on the generalization of newly taught mands were evaluated in a multielement design. Results indicated differentiated responding during generalization probes in which more manding with the target mand was observed following the presession no-access condition than in the presession access condition. These results support the consideration of motivating operations when assessing generalization of target mands to various untrained contexts.
C1 [Fragale, Christina L.] Univ Texas Austin, Dept Special Educ, Meadows Ctr Preventing Educ Risk, Austin, TX 78712 USA.
[Lang, Russell] Texas State Univ San Marcos, San Marcos, TX USA.
[Sigafoos, Jeff] Victoria Univ Wellington, Wellington, New Zealand.
[Lancioni, Giulio] Univ Bari, I-70121 Bari, Italy.
RP Fragale, CL (reprint author), Univ Texas Austin, Dept Special Educ, Meadows Ctr Preventing Educ Risk, 1 Univ Stn,D5300, Austin, TX 78712 USA.
EM tinafragale@gmail.com
CR BAER DM, 1968, J APPL BEHAV ANAL, V1, P91, DOI 10.1901/jaba.1968.1-91
Chappell N, 2009, RES AUTISM SPECT DIS, V3, P660, DOI 10.1016/j.rasd.2009.01.002
Cuvo A. J., 2003, J BEHAV ED, V12, P77, DOI 10.1023/A:1022374406394
DeLeon IG, 1996, J APPL BEHAV ANAL, V29, P519, DOI 10.1901/jaba.1996.29-519
Johnston J M, 1979, Behav Anal, V2, P1
Lang R, 2010, BEHAV MODIF, V34, P267, DOI 10.1177/0145445510370713
Langthorne P, 2007, BEHAV MODIF, V31, P466, DOI 10.1177/0145445506298424
Laraway S, 2003, J APPL BEHAV ANAL, V36, P407, DOI 10.1901/jaba.2003.36-407
McComas J, 2000, J APPL BEHAV ANAL, V33, P479, DOI 10.1901/jaba.2000.33-479
MICHAEL J, 1982, J EXP ANAL BEHAV, V37, P149, DOI 10.1901/jeab.1982.37-149
National Research Council, 2001, ED CHILDR AUT
O'Reilly M., J APPL BEHA IN PRESS
O'Reilly M, 2009, J APPL BEHAV ANAL, V42, P773, DOI 10.1901/jaba.2009.42-773
O'Reilly M, 2007, BEHAV INTERVENT, V22, P137, DOI 10.1002/bin.226
O'Reilly MF, 2008, RES DEV DISABIL, V29, P333, DOI 10.1016/j.ridd.2007.06.004
PELLECCHIA M., 2007, BEHAV ANAL TODAY, V8, P483
Reed DD, 2009, J DEV PHYS DISABIL, V21, P485, DOI 10.1007/s10882-009-9159-3
Rispoli M, 2011, J APPL BEHAV ANAL, V44, P187, DOI 10.1901/jaba.2011.44-187
Roantree CF, 2006, J APPL BEHAV ANAL, V39, P381, DOI 10.1901/jaba.2006.97-05
Schopler E., 1988, CHILDHOOD AUTISM RAT
Scott J., 2000, STUDENTS AUTISM CHAR, P205
Shafer E., 1994, ANAL VERBAL BEHAV, V12, P53
Skinner B. F., 1957, VERBAL BEHAV
STOKES TF, 1977, J APPL BEHAV ANAL, V10, P349, DOI 10.1901/jaba.1977.10-349
Sundberg M. L., 2002, ANAL VERBAL BEHAV, V18, P15
Sundberg ML, 2001, BEHAV MODIF, V25, P698, DOI 10.1177/0145445501255003
Taylor BA, 2005, RES DEV DISABIL, V26, P385, DOI 10.1016/j.ridd.2004.11.003
TAYLOR BA, 1995, J APPL BEHAV ANAL, V28, P3, DOI 10.1901/jaba.1995.28-3
NR 28
TC 2
Z9 2
PU JOURNAL APPL BEHAV ANAL
PI LAWRENCE
PA DEPT HUMAN DEVELOPMENT, UNIV KANSAS, LAWRENCE, KS 66045 USA
SN 0021-8855
J9 J APPL BEHAV ANAL
JI J. Appl. Behav. Anal.
PD FAL
PY 2012
VL 45
IS 3
BP 565
EP 577
DI 10.1901/jaba.2012.45-565
PG 13
WC Psychology, Clinical
SC Psychology
GA 020BB
UT WOS:000309782500009
PM 23060669
ER
PT J
AU Roantree, CF
Kennedy, CH
AF Roantree, Christina F.
Kennedy, Craig H.
TI FUNCTIONAL ANALYSIS OF INAPPROPRIATE SOCIAL INTERACTIONS IN STUDENTS
WITH ASPERGER'S SYNDROME
SO JOURNAL OF APPLIED BEHAVIOR ANALYSIS
LA English
DT Article
DE autism spectrum disorder; Asperger's syndrome; social skills; social
interaction; functional analysis
AB We analyzed the inappropriate social interactions of 3 students with Asperger's syndrome whose behavior was maintained by social positive reinforcement. We tested whether inappropriate social behavior was sensitive to social positive reinforcement contingencies and whether such contingencies could be reversed to increase the probability of socially appropriate responding. Our results show that social positive reinforcers can be identified for inappropriate social interactions and that appropriate social behaviors can be sensitive to reinforcement contingency reversals.
C1 [Kennedy, Craig H.] Vanderbilt Univ, Peabody Coll, Nashville, TN 37212 USA.
RP Kennedy, CH (reprint author), Vanderbilt Univ, Peabody Coll, Peabody Adm Bldg,Box 329, Nashville, TN 37212 USA.
EM craig.kennedy@vanderbilt.edu
CR American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th
Fombonne E, 2009, PEDIATR RES, V65, P591, DOI 10.1203/PDR.0b013e31819e7203
IWATA BA, 1994, J APPL BEHAV ANAL, V27, P197, DOI 10.1901/jaba.1994.27-197
Kennedy C, 2005, SINGLE CASE DESIGNS
Kennedy C. H., 2004, INT HDB APPL RES INT, P297, DOI 10.1002/9780470713198.ch14
Klin A., 2005, HDB AUTISM PERVASIVE, V1, P88
McCarthy D., 1988, MATCHING LAW RES REV
Rehfeldt RA, 2003, J APPL BEHAV ANAL, V36, P259, DOI 10.1901/jaba.2003.36-259
NR 8
TC 1
Z9 1
PU JOURNAL APPL BEHAV ANAL
PI LAWRENCE
PA DEPT HUMAN DEVELOPMENT, UNIV KANSAS, LAWRENCE, KS 66045 USA
SN 0021-8855
J9 J APPL BEHAV ANAL
JI J. Appl. Behav. Anal.
PD FAL
PY 2012
VL 45
IS 3
BP 585
EP 591
DI 10.1901/jaba.2012.45-585
PG 7
WC Psychology, Clinical
SC Psychology
GA 020BB
UT WOS:000309782500011
PM 23060671
ER
PT J
AU Polick, AS
Carr, JE
Hanney, NM
AF Polick, Amy S.
Carr, James E.
Hanney, Nicole M.
TI A COMPARISON OF GENERAL AND DESCRIPTIVE PRAISE IN TEACHING INTRAVERBAL
BEHAVIOR TO CHILDREN WITH AUTISM
SO JOURNAL OF APPLIED BEHAVIOR ANALYSIS
LA English
DT Article
DE autism; behavior-specific praise; descriptive praise; intraverbals;
praise; reinforcement; verbal behavior
AB Descriptive praise has been recommended widely as an important teaching tactic for children with autism, despite the absence of published supporting evidence. We compared the effects of descriptive and general praise on the acquisition and maintenance of intraverbal skills with 2 children with autism. The results showed slight advantages of descriptive praise in teaching efficiency in the majority of comparisons; however, these effects dissipated over time.
C1 [Polick, Amy S.] Florida State Univ, Panama City, FL 32405 USA.
[Carr, James E.; Hanney, Nicole M.] Auburn Univ, Auburn, AL 36849 USA.
RP Polick, AS (reprint author), Florida State Univ, 4750 Collegiate Dr, Panama City, FL 32405 USA.
EM apolick@pc.fsu.edu
CR Anderson S. R., 1996, BEHAV INTERVENTION Y, P181
BROPHY J, 1981, REV EDUC RES, V51, P5, DOI 10.3102/00346543051001005
Carr JE, 2000, J APPL BEHAV ANAL, V33, P353, DOI 10.1901/jaba.2000.33-353
Leaf R., 1999, WORK PROGR BEHAV MAN
Reinke WM, 2007, BEHAV MODIF, V31, P247, DOI 10.1177/0145445506288967
Sindelar P. T., 1985, ED TREATMENT CHILDRE, V8, P67
Stevens C, 2011, RES AUTISM SPECT DIS, V5, P666, DOI 10.1016/j.rasd.2010.08.003
Sundberg M. L., 2008, VB MAPP VERBAL BEHAV
Sutherland KS, 2000, J EMOT BEHAV DISORD, V8, P2, DOI 10.1177/106342660000800101
NR 9
TC 0
Z9 0
PU JOURNAL APPL BEHAV ANAL
PI LAWRENCE
PA DEPT HUMAN DEVELOPMENT, UNIV KANSAS, LAWRENCE, KS 66045 USA
SN 0021-8855
J9 J APPL BEHAV ANAL
JI J. Appl. Behav. Anal.
PD FAL
PY 2012
VL 45
IS 3
BP 593
EP 599
DI 10.1901/jaba.2012.45-593
PG 7
WC Psychology, Clinical
SC Psychology
GA 020BB
UT WOS:000309782500012
PM 23060672
ER
PT J
AU Grannan, L
Rehfeldt, RA
AF Grannan, Leigh
Rehfeldt, Ruth Anne
TI EMERGENT INTRAVERBAL RESPONSES VIA TACT AND MATCH-TO-SAMPLE INSTRUCTION
SO JOURNAL OF APPLIED BEHAVIOR ANALYSIS
LA English
DT Article
DE verbal behavior; intraverbals; autism
ID BEHAVIOR
AB The present investigation evaluated the effectiveness of category tact and match-to-sample instruction in facilitating the emergence of intraverbal responses (i.e., naming several items belonging to a specific category) for 2 children with autism. Results demonstrated the emergence of untaught responses, suggesting an effective instructional protocol for establishing intraverbal responses without direct instruction.
C1 [Rehfeldt, Ruth Anne] So Illinois Univ, Inst Rehabil, Behav Anal & Therapy Program, Carbondale, IL 62901 USA.
RP Rehfeldt, RA (reprint author), So Illinois Univ, Inst Rehabil, Behav Anal & Therapy Program, Carbondale, IL 62901 USA.
EM rehfeldt@siu.edu
CR Barnes-Holmes D, 2000, BEHAV ANALYST, V23, P69
Carr J. E., 2005, J EARLY INTENSIVE BE, V2, P18
Goldsmith TR, 2007, RES AUTISM SPECT DIS, V1, P1, DOI 10.1016/j.rasd.2006.07.001
Horne PJ, 1996, J EXP ANAL BEHAV, V65, P185, DOI 10.1901/jeab.1996.65-185
LUCIANO MC, 1986, APPL RES MENT RETARD, V7, P1
Miguel Caio F, 2005, Anal Verbal Behav, V21, P27
Miguel C. F., 2009, DERIVED RELATIONAL R, P129
Petursdottir AI, 2008, J APPL BEHAV ANAL, V41, P53, DOI 10.1901/jaba.2008.41-53
Sautter Rachael A, 2006, Anal Verbal Behav, V22, P35
Skinner B. F., 1957, VERBAL BEHAV
Sundberg M. L., 2008, VERBAL BEHAV MILESTO
NR 11
TC 3
Z9 3
PU JOURNAL APPL BEHAV ANAL
PI LAWRENCE
PA DEPT HUMAN DEVELOPMENT, UNIV KANSAS, LAWRENCE, KS 66045 USA
SN 0021-8855
J9 J APPL BEHAV ANAL
JI J. Appl. Behav. Anal.
PD FAL
PY 2012
VL 45
IS 3
BP 601
EP 605
DI 10.1901/jaba.2012.45-601
PG 5
WC Psychology, Clinical
SC Psychology
GA 020BB
UT WOS:000309782500013
PM 23060673
ER
PT J
AU Allison, J
Wilder, DA
Chong, I
Lugo, A
Pike, J
Rudy, N
AF Allison, Janelle
Wilder, David A.
Chong, Ivy
Lugo, Ashley
Pike, Jessica
Rudy, Nikki
TI A COMPARISON OF DIFFERENTIAL REINFORCEMENT AND NONCONTINGENT
REINFORCEMENT TO TREAT FOOD SELECTIVITY IN A CHILD WITH AUTISM
SO JOURNAL OF APPLIED BEHAVIOR ANALYSIS
LA English
DT Article
DE autism; differential reinforcement; escape extinction; food selectivity;
noncontingent reinforcement
ID ESCAPE EXTINCTION; REFUSAL
AB We compared differential reinforcement plus escape extinction to noncontingent reinforcement plus escape extinction to treat food selectivity exhibited by a young child with autism. The interventions were equally effective for increasing bite acceptance and decreasing problem behaviors. However, a social validity measure suggested that noncontingent reinforcement was preferred by the child's caregiver.
C1 [Allison, Janelle] Florida Inst Technol, Sch Psychol, Melbourne, FL 32901 USA.
RP Allison, J (reprint author), Florida Inst Technol, Sch Psychol, 150 W Univ Blvd, Melbourne, FL 32901 USA.
EM jallison2008@my.fit.edu; dawilder@fit.edu
CR Bachmeyer MH, 2009, J APPL BEHAV ANAL, V42, P641, DOI 10.1901/jaba.2009.42-641
FISHER W, 1992, J APPL BEHAV ANAL, V25, P491, DOI 10.1901/jaba.1992.25-491
Piazza CC, 2003, J APPL BEHAV ANAL, V36, P309, DOI 10.1901/jaba.2003.36-309
Reed GK, 2004, J APPL BEHAV ANAL, V37, P27, DOI 10.1901/jaba.2004.37-27
NR 4
TC 2
Z9 2
PU JOURNAL APPL BEHAV ANAL
PI LAWRENCE
PA DEPT HUMAN DEVELOPMENT, UNIV KANSAS, LAWRENCE, KS 66045 USA
SN 0021-8855
J9 J APPL BEHAV ANAL
JI J. Appl. Behav. Anal.
PD FAL
PY 2012
VL 45
IS 3
BP 613
EP 617
DI 10.1901/jaba.2012.45-613
PG 5
WC Psychology, Clinical
SC Psychology
GA 020BB
UT WOS:000309782500015
PM 23060675
ER
PT J
AU Slocum, SK
Miller, SJ
Tiger, JH
AF Slocum, Sarah K.
Miller, Sarah J.
Tiger, Jeffrey H.
TI USING A BLOCKED-TRIALS PROCEDURE TO TEACH IDENTITY MATCHING TO A CHILD
WITH AUTISM
SO JOURNAL OF APPLIED BEHAVIOR ANALYSIS
LA English
DT Article
DE autism; blocked trials; children; conditional discrimination; identity
matching
ID MENTALLY-RETARDED ADULTS; CONDITIONAL DISCRIMINATION
AB Children with autism may struggle in developing conditional discrimination repertoires. Saunders and Spradlin (1989, 1990, 1993) arranged "blocked" teaching trials in which they presented the same sample stimulus repeatedly across trials (in lieu of randomly alternating targets across trials) and then faded the number of trials in each block. We replicated the effects of this blocked-trials procedure in teaching identity matching to a child with autism and evaluated the necessity of fading. Arranging blocked trials facilitated the acquisition of identity matching, but fading the block size was not necessary to maintain discriminated performance.
C1 [Tiger, Jeffrey H.] Univ Wisconsin, Dept Psychol, Milwaukee, WI 53201 USA.
[Miller, Sarah J.] Louisiana State Univ, Baton Rouge, LA 70803 USA.
[Slocum, Sarah K.] Univ Florida, Gainesville, FL 32611 USA.
RP Tiger, JH (reprint author), Univ Wisconsin, Dept Psychol, 219 Garland, Milwaukee, WI 53201 USA.
EM tiger@uwm.edu
CR FISHER W, 1992, J APPL BEHAV ANAL, V25, P491, DOI 10.1901/jaba.1992.25-491
Green G., 2001, FOCUS AUTISM OTHER D, V16, P72, DOI 10.1177/108835760101600203
Maurice C., 1996, BEHAV INTERVENTION Y
Perez-Gonzalez LA, 2002, AM J MENT RETARD, V107, P293, DOI 10.1352/0895-8017(2002)107<0293:MPTTCD>2.0.CO;2
SAUNDERS KJ, 1993, J EXP ANAL BEHAV, V60, P571, DOI 10.1901/jeab.1993.60-571
SAUNDERS KJ, 1989, J EXP ANAL BEHAV, V52, P1, DOI 10.1901/jeab.1989.52-1
SAUNDERS KJ, 1990, J EXP ANAL BEHAV, V54, P239, DOI 10.1901/jeab.1990.54-239
Sundberg M. L., 2008, VERBAL BEHAV MILESTO
Williams G, 2005, J APPL BEHAV ANAL, V38, P555, DOI 10.1901/jaba.2005.65-04
NR 9
TC 0
Z9 0
PU JOURNAL APPL BEHAV ANAL
PI LAWRENCE
PA DEPT HUMAN DEVELOPMENT, UNIV KANSAS, LAWRENCE, KS 66045 USA
SN 0021-8855
J9 J APPL BEHAV ANAL
JI J. Appl. Behav. Anal.
PD FAL
PY 2012
VL 45
IS 3
BP 619
EP 624
DI 10.1901/jaba.2012.45-619
PG 6
WC Psychology, Clinical
SC Psychology
GA 020BB
UT WOS:000309782500016
PM 23060677
ER
PT J
AU Keyl-Austin, AA
Samaha, AL
Bloom, SE
Boyle, MA
AF Keyl-Austin, Alice A.
Samaha, Andrew L.
Bloom, Sarah E.
Boyle, Megan A.
TI EFFECTS OF PREFERENCE AND REINFORCER VARIATION ON WITHIN-SESSION
PATTERNS OF RESPONDING
SO JOURNAL OF APPLIED BEHAVIOR ANALYSIS
LA English
DT Article
DE autism; preference assessment; behavioral economics; bridge study;
marginal utility
ID CHILDREN
AB We examined correspondence between preference assessment outcome and within-session patterns of responding in one subject with autism. Responding maintained by a single highly preferred item resulted in a greater total number of responses, a slower decline in within-session response rates, and a greater proportion of short interresponse times compared to responding maintained by varied moderately preferred (MP) stimuli. Presenting varied MP stimuli within the same session produced greater levels and more sustained responding than presenting those same stimuli individually.
C1 [Samaha, Andrew L.] Utah State Univ, Dept Psychol, Logan, UT 84322 USA.
RP Samaha, AL (reprint author), Utah State Univ, Dept Psychol, 2810 Old Main Hill, Logan, UT 84322 USA.
EM andrew.samaha@usu.edu
RI Samaha, Andrew/F-4508-2010
CR Bohm-Bawerk E., 1891, POSITIVE THEORY CAPI
DeLeon IG, 1996, J APPL BEHAV ANAL, V29, P519, DOI 10.1901/jaba.1996.29-519
EGEL AL, 1980, J EXP CHILD PSYCHOL, V30, P455, DOI 10.1016/0022-0965(80)90050-8
EGEL AL, 1981, J APPL BEHAV ANAL, V14, P345, DOI 10.1901/jaba.1981.14-345
FISHER W, 1992, J APPL BEHAV ANAL, V25, P491, DOI 10.1901/jaba.1992.25-491
Glover AC, 2008, J APPL BEHAV ANAL, V41, P163, DOI 10.1901/jaba.2008.41-163
Koehler LJ, 2005, J APPL BEHAV ANAL, V38, P469, DOI 10.1901/jaba.2005.102-04
Lee MSH, 2010, J APPL BEHAV ANAL, V43, P95, DOI 10.1901/jaba.2010.43-95
Murphy ES, 2003, J APPL BEHAV ANAL, V36, P421, DOI 10.1901/jaba.2003.36-421
North ST, 2005, J APPL BEHAV ANAL, V38, P317, DOI 10.1901/jaba.2005.93-04
Roane HS, 2001, J APPL BEHAV ANAL, V34, P145, DOI 10.1901/jaba.2001.34-145
Roscoe EM, 1999, J APPL BEHAV ANAL, V32, P479, DOI 10.1901/jaba.1999.32-479
NR 12
TC 1
Z9 1
PU JOURNAL APPL BEHAV ANAL
PI LAWRENCE
PA DEPT HUMAN DEVELOPMENT, UNIV KANSAS, LAWRENCE, KS 66045 USA
SN 0021-8855
J9 J APPL BEHAV ANAL
JI J. Appl. Behav. Anal.
PD FAL
PY 2012
VL 45
IS 3
BP 637
EP 641
DI 10.1901/jaba.2012.45-637
PG 5
WC Psychology, Clinical
SC Psychology
GA 020BB
UT WOS:000309782500019
PM 23060680
ER
PT J
AU Maisonneuve, H
Floret, D
AF Maisonneuve, Herve
Floret, Daniel
TI Wakefield's affair: 12 years of uncertainty whereas no link between
autism and MMR vaccine has been proved
SO PRESSE MEDICALE
LA French
DT Article
ID STATEMENT; SECRETS; COLITIS; SEE
AB In 1998, a Lancet paper described 12 cases of children with autism, and having been vaccinated (MMR) in the United Kingdom; medias presented the information to the lay public, stating that a link was possible.
In 2004, The Lancet published letters responding to allegations against the paper.
Later, it was established that no link existed between MMR and autism; few years and many publications were necessary to conclude to the absence of evidence.
In 2010, the General Medical Council published a report against Dr Wakefield, first author of the 1998 paper, and showing that the children hospital records did not contain the evidence; hospital records differed from the published paper; the Lancet retracted the 1998 paper.
In 2011, Brian Deer, a journalist, published the complete story in the BMJ: in 1996, Wakefield was approached by lawyers representing on anti-vaccine lobby, and they supported the Wakefield research.
Dr Wakefield left England; in 2012 he works in Texas, USA, for anti-vaccine lobbies.
C1 [Maisonneuve, Herve] Fac Med Paris Sud 11, Dept Sante Publ Evaluat & Informat Med, F-94277 Le Kremlin Bicetre, France.
[Floret, Daniel] Univ Lyon 1, Hop Femme Mere Enfant, F-69677 Bron, France.
RP Maisonneuve, H (reprint author), Fac Med Paris Sud 11, Dept Sante Publ Evaluat & Informat Med, 63 Rue Gabriel Peri, F-94277 Le Kremlin Bicetre, France.
EM hervemaisonneuve@gmail.com
CR [Anonymous], PIG AW
[Anonymous], 2010, LANCET, V375, P445
[Anonymous], 2011, STUDENT BMJ
[Anonymous], 2011, COMMUNICATION APR
Bjarnason I, 2011, BMJ-BRIT MED J, V343, DOI 10.1136/bmj.d6979
Cunningham D, 2010, FACTS CASE A WAKEFIE
Deer B, 2011, BRIT MED J, V343, DOI 10.1136/bmj.d6823
DEER B, 2011, BRIT MED J, V342, P136
Deer B, 2011, BRIT MED J, V342, P77
Deer B, 2011, BRIT MED J, V342, P200
Dyer C, 2012, BMJ, V344
Geboes K, 2011, BRIT MED J, V343, DOI 10.1136/bmj.d6985
General Medical Council, 2010, AJ WAK DET SER PROF
Godlee F, 2011, BRIT MED J, V343, DOI 10.1136/bmj.d7284
Hodgson H, 2004, LANCET, V363, P824, DOI 10.1016/S0140-6736(04)15711-5
Horton R, 2004, LANCET, V363, P820, DOI 10.1016/S0140-6736(04)15699-7
Mnookin S., 2011, PANIC VIRUS TRUE STO
Mursh S, 2004, LANCET, V363, P821
Sox HC, 2009, ANN INTERN MED, V151, P68
Wakefield A, 2004, LANCET, V363, P823, DOI 10.1016/S0140-6736(04)15710-3
Wakefield A. J., 2010, CALLOUS DISREGARD AU
Wakefield A.J, 2010, CALLLOUS DISREGARD A
Wakefield AJ, 1998, LANCET, V351, P637, DOI 10.1016/S0140-6736(97)11096-0
Walker-Smith J, 2004, LANCET, V363, P822, DOI 10.1016/S0140-6736(04)15709-7
NR 24
TC 1
Z9 1
PU MASSON EDITEUR
PI MOULINEAUX CEDEX 9
PA 21 STREET CAMILLE DESMOULINS, ISSY, 92789 MOULINEAUX CEDEX 9, FRANCE
SN 0755-4982
J9 PRESSE MED
JI Presse Med.
PD SEP
PY 2012
VL 41
IS 9
BP 827
EP 834
DI 10.1016/j.lpm.2012.03.022
PN 1
PG 8
WC Medicine, General & Internal
SC General & Internal Medicine
GA 017UJ
UT WOS:000309616200008
PM 22748860
ER
PT J
AU Kuorikoski, J
Poyhonen, S
AF Kuorikoski, Jaakko
Poyhonen, Samuli
TI Looping Kinds and Social Mechanisms
SO SOCIOLOGICAL THEORY
LA English
DT Article
DE looping effect; classification; social construction; middle-range
theory; social mechanism
ID NATURAL KINDS; MENTAL-DISORDERS; SELF-INTEREST; SCIENCES; AUTISM;
ATTITUDES; ILLNESS; REALISM; STIGMA; PEOPLE
AB Human behavior is not always independent of the ways in which humans are scientifically classified. That there are looping effects of human kinds has been used as an argument for the methodological separation of the natural and the human sciences and to justify social constructionist claims. We suggest that these arguments rely on false presuppositions and present a mechanisms-based account of looping that provides a better way to understand the phenomenon and its theoretical and philosophical implications.
C1 [Kuorikoski, Jaakko] Univ Helsinki, Dept Polit & Econ Studies, FIN-00014 Helsinki, Finland.
[Kuorikoski, Jaakko; Poyhonen, Samuli] Univ Helsinki, Finnish Ctr Excellence Philosophy Social Sci, FIN-00014 Helsinki, Finland.
RP Kuorikoski, J (reprint author), Univ Helsinki, Dept Polit & Econ Studies, POB 24, FIN-00014 Helsinki, Finland.
EM jaakko.kuorikoski@helsinki.fi
CR Angermeyer MC, 2003, ACTA PSYCHIAT SCAND, V108, P304, DOI 10.1034/j.1600-0447.2003.00150.x
Bailey A, 1996, J CHILD PSYCHOL PSYC, V37, P89, DOI 10.1111/j.1469-7610.1996.tb01381.x
BARNES B, 1983, SOCIOLOGY, V17, P524, DOI 10.1177/0038038583017004004
Baron-Cohen S, 2001, J AUTISM DEV DISORD, V31, P5, DOI 10.1023/A:1005653411471
Bearman Peter, 2009, OXFORD HDB ANAL SOCI
Bourdieu P., 1992, INVITATION REFLEXIVE
Bowker G. C., 1999, SORTING THINGS OUT C
BOYD R, 1991, PHILOS STUD, V61, P127, DOI 10.1007/BF00385837
BOYD R, 1989, DIALECTICA, V43, P5, DOI 10.1111/j.1746-8361.1989.tb00928.x
Boyd Richard N, 1999, RATIONALITAT REALISM, P52
Burr V., 1995, INTRO SOCIAL CONSTRU
Callon M, 1998, LAWS OF THE MARKETS, P1
Clarke AE, 2003, AM SOCIOL REV, V68, P161, DOI 10.2307/1519765
Conrad P, 2007, MEDICALIZATION SOC T
Craver CF, 2009, PHILOS PSYCHOL, V22, P575, DOI 10.1080/09515080903238930
Eyal Gil, 2010, AUTISM MATRIX SOCIAL
Ferraro F, 2005, ACAD MANAGE REV, V30, P8
Fodor J, 1974, SYNTHESE, V28, P97, DOI DOI 10.1007/BF00485230
Foucault M., 1976, HIST SEXUALITE
Foucault M., 1961, FOLIE DERAISON HIST
Frey BS, 2001, J ECON SURV, V15, P589, DOI 10.1111/1467-6419.00150
Gelman S. A., 2003, ESSENTIAL CHILD
Gergen K. J., 1996, MESSAGE SOCIAL PSYCH, P113
Giddens A, 1984, CONSTITUTION SOC
Giddens A., 1991, MODERNITY SELF IDENT
Goffman E, 1963, STIGMA NOTES MANAGEM
Goodman N., 1983, FACT FICTION FORECAS, V4th
Green T. H., 1964, PHILOS WORKS, V3
Grene M., 2004, PHILOS BIOL EPISODIC
Griffiths Paul, 1997, WHAT EMOTIONS REALLY
HACKING I, 1991, PHILOS STUD, V61, P109, DOI 10.1007/BF00385836
Hacking I, 2004, ECON SOC, V33, P277, DOI 10.1080/0308514042000225671
Hacking Ian, 2006, COMMUNICATION
Hacking Ian, 2002, HIST ONTOLOGY
Hacking I, 1995, SYMP SYSSEN FDN, P351
Hacking Ian, 1999, SOCIAL CONSTRUCTION
Hedstrom P, 2010, ANNU REV SOCIOL, V36, P49, DOI 10.1146/annurev.soc.012809.102632
HEDSTROM P., 2005, DISSECTING SOCIAL PR
Horwitz Allan V., 2007, AM J SOCIOL, V114, P287
Jorm AF, 2008, ACTA PSYCHIAT SCAND, V118, P315, DOI 10.1111/j.1600-0447.2008.01251.x
Lamont M, 2002, ANNU REV SOCIOL, V28, P167, DOI 10.1146/annurev.soc.28.110601.141107
LAUB JH, 2006, SHARED BEGINNINGS DI
Lemert E., 1967, HUMAN DEVIANCE SOCIA
LINK BG, 1989, AM SOCIOL REV, V54, P400, DOI 10.2307/2095613
Liu KY, 2010, AM J SOCIOL, V115, P1387
Machery E., 2009, DOING CONCEPTS
Mallon Ron, 2003, SOCIALIZING METAPHYS, P327
Merton R. K., 1967, THEORETICAL SOCIOLOG
Merton R.K., 1948, ANTIOCH REV, V8, P193, DOI DOI 10.2307/4609267
Miller DT, 1999, AM PSYCHOL, V54, P1053, DOI 10.1037/0003-066X.54.12.1053
Murphy D, 2006, PSYCHIAT SCI IMAGE
Osborne T, 1999, BRIT J SOCIOL, V50, P367, DOI 10.1111/j.1468-4446.1999.00367.x
Ostrom E, 2000, SCAND POLIT STUD, V23, P3, DOI 10.1111/1467-9477.00028
Paternoster Raymond, 1989, JUSTICE Q, V6, P359, DOI 10.1080/07418828900090261
Prasada S, 2006, COGNITION, V99, P73, DOI 10.1016/j.cognition.2005.01.003
Ratner RK, 2001, J PERS SOC PSYCHOL, V81, P5, DOI 10.1037//0022-3514.81.1.5
Read J, 2009, ACTA PSYCHIAT SCAND, V119, P412, DOI 10.1111/j.1600-0447.2009.01362.x
Reydon TAC, 2009, CROAT J PHILOS, V9, P167
Rose N, 2007, POLITICS OF LIFE ITSELF: BIOMEDICINE, POWER, AND SUBJECTIVITY IN THE TWENTY-FIRST CENTURY, P1
Rosenberg A, 2005, PHILOS SOC SCI, V35, P3, DOI 10.1177/0048393104271921
Roth I, 2010, AUTISM SPECTRUM 21 C
Samuels R, 2010, BEHAV BRAIN SCI, V33, P222, DOI 10.1017/S0140525X10000452
Sayer A, 1997, SOCIOL REV, V45, P453, DOI 10.1111/1467-954X.00073
Simon HA, 1954, PUBLIC OPIN QUART, V18, P245, DOI 10.1086/266513
Singh I, 2009, NATURE, V460, P202, DOI 10.1038/460202a
Strevens M, 2000, COGNITION, V74, P149, DOI 10.1016/S0010-0277(99)00071-2
Tilly C, 2004, PHILOS SOC SCI, V34, P211, DOI 10.1177/0048393103262551
Tilly Charles, 1998, DURABLE INEQUALITY
Valentine K, 2010, SOC SCI MED, V71, P950, DOI 10.1016/j.socscimed.2010.06.010
Woodward James, 2003, MAKING THINGS HAPPEN
NR 70
TC 3
Z9 3
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0735-2751
EI 1467-9558
J9 SOCIOL THEOR
JI Sociol. Theor.
PD SEP
PY 2012
VL 30
IS 3
BP 187
EP 205
DI 10.1177/0735275112457911
PG 19
WC Sociology
SC Sociology
GA 019DN
UT WOS:000309717400003
ER
PT J
AU Nikfarjam, H
Moghimi, A
Hosseini, M
Mahdavi-Shahri, N
Edalatmanesh, MA
Vafaee-Bagheri, F
AF Nikfarjam, H.
Moghimi, A.
Hosseini, M.
Mahdavi-Shahri, N.
Edalatmanesh, M. A.
Vafaee-Bagheri, F.
TI Exaggerated fear conditioning memory and increased amygdala cell density
in the valproic acid animal model of autism
SO EUROPEAN JOURNAL OF NEUROLOGY
LA English
DT Meeting Abstract
CT 16th Congress of the European-Federation-of-Neurological-Societies
(EFNS)
CY SEP 08-11, 2012
CL Stockholm, SWEDEN
SP European Federat Neurol Soc (EFNS)
C1 [Nikfarjam, H.; Moghimi, A.; Mahdavi-Shahri, N.] Ferdowsi Univ Mashhad, Fac Sci, Dept Biol, Mashhad, Iran.
[Hosseini, M.; Vafaee-Bagheri, F.] Mashhad Univ Med Sci, Sch Med, Neurosci Res Ctr, Mashhad, Iran.
[Hosseini, M.; Vafaee-Bagheri, F.] Mashhad Univ Med Sci, Sch Med, Dept Physiol, Mashhad, Iran.
[Edalatmanesh, M. A.] Islamic Azad Univ, Sci & Res Branch, Dept Physiol, Fars, Iran.
NR 0
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1351-5101
J9 EUR J NEUROL
JI Eur. J. Neurol.
PD SEP
PY 2012
VL 19
SU 1
SI SI
BP 531
EP 531
PG 1
WC Clinical Neurology; Neurosciences
SC Neurosciences & Neurology
GA 014FD
UT WOS:000309359703129
ER
PT J
AU Brown, LS
Jellison, JA
AF Brown, Laura S.
Jellison, Judith A.
TI Music Research with Children and Youth with Disabilities and Typically
Developing Peers: A Systematic Review
SO JOURNAL OF MUSIC THERAPY
LA English
DT Review
DE music; children; disability; inclusion
ID WILLIAMS-SYNDROME; DEVELOPMENTAL-DISABILITIES; AESTHETIC EXPERIENCES;
VISUAL IMPAIRMENTS; YOUNG-CHILDREN; STUDENTS; THERAPY; AUTISM;
ADOLESCENTS; PARTICIPATION
AB Background: Systematic reviews of research provide pertinent information to both practitioners and researchers. While there are several recent reviews of music research and children with specific disabilities (primarily autism), there is no current review of music research with children with a wide variety of disabilities.
Objective: The aim of the current study is to identify and systematically review music research with children and youth published in peer reviewed journals for the years 1999 through 2009. Research questions focused on participant characteristics; research purposes, methodologies, and findings; as well as the presence of ideas from special education policies, and practices. We also asked how results have changed from those from an earlier review (Jellison, 2000).
Methods: Using computer and hand-searches, we identified 45 articles that met our criteria for inclusion. Once identified, through a process of consensus we analyzed articles based on criteria, categories, and codes used in the earlier review. Additionally we analyzed measurement instruments and effectiveness of interventions as reported by the authors.
Results: Primary findings show a large majority of studies were experimental with most reporting effective or partially effective interventions, particularly for social variables. Compared to the earlier review, increases were found for participants with autism and for reports including ideas from special education. Percentages of articles measuring generalization and examining high-incident disability populations (specific learning disabilities) were low.
Conclusions: The findings from this review and comparisons to the earlier review reveal important implications for practices with children with autism and preparation of researchers to design and conduct studies in inclusive music settings.
C1 [Brown, Laura S.] Western Illinois Univ, Macomb, IL 61455 USA.
[Jellison, Judith A.] Univ Texas Austin, Butler Sch Mus, Ctr Mus Learning, Austin, TX 78712 USA.
RP Brown, LS (reprint author), Western Illinois Univ, Macomb, IL 61455 USA.
CR Accordino R, 2007, RES AUTISM SPECT DIS, V1, P101, DOI 10.1016/j.rasd.2006.08.002
American Music Therapy Association, 2011, SNAPSH MUS THER PROF
American Music Therapy Association, 2009, AMTA 2009 ANN REP
Benson NJ, 2000, J EDUC PSYCHOL, V92, P646, DOI 10.1037//0022-0663.92.4.646
Brownell MD, 2002, J MUSIC THER, V39, P117
Buckley SD, 2006, J APPL BEHAV ANAL, V39, P141, DOI 10.1901/jaba.2006.120-04
Carey Y. A., 2002, ED TREATMENT CHILDRE, V25, P131
Carnahan C., 2009, EDUC TREAT CHILD, V32, P37, DOI [DOI 10.1353/ETC.0.0047, 10.1353/etc.0.0047]
Centers for Disease Control and Prevention, 2009, MMWR-MORBID MORTAL W, V58, P1
Chan JM, 2009, RES AUTISM SPECT DIS, V3, P876, DOI 10.1016/j.rasd.2009.04.003
Colwell C. M., 2002, MUSIC THERAPY PERSPE, V20, P13
Colwell CM, 2001, J MUSIC THER, V38, P321
Darrow AA, 2006, J MUSIC THER, V43, P2
Darrow AA, 2007, J MUSIC THER, V44, P57
DeBedout JK, 2006, J MUSIC THER, V43, P123
Dellatan A., 2003, MUSIC THERAPY PERSPE, V21, P105
Duffy B, 2000, J APPL RES INTELLECT, V13, P77, DOI 10.1046/j.1468-3148.2000.00011.x
Dykens EM, 2005, AM J MENT RETARD, V110, P346, DOI 10.1352/0895-8017(2005)110[346:MAAIWS]2.0.CO;2
Edelson SM, 1999, FOCUS AUTISM OTHER D, V14, P73, DOI 10.1177/108835769901400202
Elefant C., 2006, COCHRANE DATABASE SY
Flowers PJ, 2002, J RES MUSIC EDUC, V50, P202, DOI 10.2307/3345798
Ghetti C. M., 2002, MUSIC THERPAY PERSPE, V20, P20
Gold C, 2004, J CHILD PSYCHOL PSYC, V45, P1054, DOI 10.1111/j.1469-7610.2004.t01-1-00298.x
Hooper J., 2008, MUSIC THERAPY PERSPE, V26, p80?96
Hooper J, 2008, MUSIC THERAPY PERSPE, V26, P66
Horner RH, 2005, EXCEPT CHILDREN, V71, P165
Jellison J. A., 2000, EFFECTIVENESS MUSIC, P199
Jellison JA, 2002, J RES MUSIC EDUC, V50, P343, DOI 10.2307/3345360
Johnson CM, 2003, B COUN RES MUSIC ED, P33
Katagiri J, 2009, J MUSIC THER, V46, P15
Kern P, 2001, J MUSIC THER, V38, P149
Kern Petra, 2006, J Music Ther, V43, P270
Kern P., 2007, MUSIC THERAPY PERSPE, V25, P43
Kern P, 2007, J AUTISM DEV DISORD, V37, P1264, DOI 10.1007/s10803-006-0272-1
Komi T., 2006, CHILD LANG TEACH THE, V22, P293, DOI 10.1191/0265659006ct309xx
Kouri T, 2008, CHILD LANG TEACH THE, V24, P329, DOI 10.1177/0265659008096296
Kwak EE, 2007, J MUSIC THER, V44, P198
Lenhoff HM, 2001, MUSIC PERCEPT, V18, P491, DOI 10.1525/mp.2001.18.4.491
Levitin DJ, 2004, CHILD NEUROPSYCHOL, V10, P223, DOI 10.1080/09297040490909288
Odom S. L., 2003, FOCUS AUTISM OTHER D, V18, P166, DOI DOI 10.1177/10883576030180030401
Pasiali V., 2004, MUSIC THERAPY PERSPE, V22, P11
Paul PM, 2008, J MUSIC THER, V45, P135
Paul PM, 2008, J MUSIC THER, V45, P427
Perry MMR, 2003, J MUSIC THER, V40, P227
Register D, 2004, J MUSIC THER, V41, P2
Register D, 2001, J MUSIC THER, V38, P239
Register D., 2007, MUSIC THERAPY PERSPE, V25, P25
Register D, 2007, J MUSIC THER, V44, P23
Rickson DJ, 2003, J MUSIC THER, V40, P283
Rickson DJ, 2006, J MUSIC THER, V43, P39
Robb SL, 2003, J MUSIC THER, V40, P266
Saracino J, 2010, J DEV PHYS DISABIL, V22, P317, DOI 10.1007/s10882-010-9205-1
Schraer-Joiner L., 2009, EARLY CHILDHOOD DEV, V179, P785
Shields C, 2001, J RES MUSIC EDUC, V49, P273, DOI 10.2307/3345712
Stephens CE, 2008, AUTISM, V12, P645, DOI 10.1177/1362361308097117
Stordahl J, 2002, J MUSIC THER, V39, P2
Sussman JE, 2009, J MUSIC THER, V46, P53
Young Margaret B., 2012, Morbidity and Mortality Weekly Report, V61, P1
Tincani M., 2009, MUSIC THERAPY PERSPE, V27, P88
U.S. Department of Education, 2007, 29 C IMPL IND DIS ED
Webster AA, 2007, J INTELLECT DEV DIS, V32, P200, DOI 10.1080/13668250701549443
Whipple J, 2004, J MUSIC THER, V41, P90
NR 62
TC 4
Z9 4
PU NATL ASSOC MUSIC THERAPY INC
PI SILVER SPRING
PA 8455 COLESVILLE RD, STE 1000, SILVER SPRING, MD 20910 USA
SN 0022-2917
J9 J MUSIC THER
JI J. Music Ther.
PD FAL
PY 2012
VL 49
IS 3
BP 335
EP 364
PG 30
WC Music; Rehabilitation
SC Music; Rehabilitation
GA 015YN
UT WOS:000309484300004
PM 23259233
ER
PT J
AU Coker, TR
Shaikh, Y
Chung, PJ
AF Coker, Tumaini R.
Shaikh, Yahya
Chung, Paul J.
TI Parent-Reported Quality of Preventive Care for Children At-Risk for
Developmental Delay
SO ACADEMIC PEDIATRICS
LA English
DT Article
DE developmental delay; developmental screening; preventive care; quality
ID YOUNG-CHILDREN; MEDICAL HOME; PEDIATRIC OFFICE; US CHILDREN; AGE;
DIAGNOSIS; NEEDS; DISPARITIES; PREVALENCE; AUTISM
AB OBJECTIVE: To compare preventive care quality for children at risk and not at risk for developmental, behavioral, or social delays.
METHODS: Using the 2007 National Survey of Children's Health (n = 22,269), we used the Parents' Evaluation of Developmental Status (PEDS) questionnaire to identify children ages 10 months to 5 years who were at risk for delays. We examined parent-reported quality measures to evaluate whether care was comprehensive, coordinated, family-centered, effective in providing developmental surveillance and screening, and provided within a medical home. Bivariate and multivariate analyses were used.
RESULTS: Twenty-eight percent of children were at-risk for delay, with 17% at moderate risk and 11% at high risk. Greater proportions of children at high, moderate, and no/low risk had a usual source of care (89%-96%) and a personal doctor/nurse (91%-94%); smaller proportions of children underwent a standardized developmental screening (16%-23%) and had parental developmental concerns elicited from their doctor (47%-48%). In adjusted analyses, moderate-risk and high-risk children were less likely than no/low-risk children to receive needed care coordination (adjusted odds ratio [AOR] for high risk 0.33, 95% confidence interval [95% CI] 0.24-0.46) and referrals (high risk AOR 0.40, 95% CI 0.25-0.65), family-centered care (high-risk AOR 0.47, 95% CI 0.36-0.62), and to have a medical home (high-risk AOR 0.41, 95% CI 0.32-0.54).
CONCLUSIONS: Our findings may reflect either poorer quality of care provided to at-risk children, or higher level of parental need that routine visits are not currently meeting. For at-risk children, enhanced screening and detection followed by targeted increases in communication and follow-up may help clinicians better anticipate families' needs.
C1 [Coker, Tumaini R.; Chung, Paul J.] Univ Calif Los Angeles, RAND Ctr Adolescent Hlth Promot, David Geffen Sch Med, Dept Pediat, Los Angeles, CA 90024 USA.
[Coker, Tumaini R.; Chung, Paul J.] Univ Calif Los Angeles, Mattel Childrens Hosp, Los Angeles, CA 90024 USA.
[Coker, Tumaini R.; Chung, Paul J.] RAND Corp, Santa Monica, CA USA.
[Chung, Paul J.] Univ Calif Los Angeles, Sch Publ Hlth, Dept Hlth Serv, Los Angeles, CA 90024 USA.
RP Coker, TR (reprint author), Univ Calif Los Angeles, RAND Ctr Adolescent Hlth Promot, David Geffen Sch Med, Dept Pediat, 10960 Wilshire Blvd,Suite 1550, Los Angeles, CA 90024 USA.
EM tcoker@mednet.ucla.edu
FU Eunice Kennedy Shriver National Institute of Child Health and Human
Development
FX Dr. Coker was supported by a Eunice Kennedy Shriver National Institute
of Child Health and Human Development K23 mentored patient-oriented
research career development award.
CR American Academy of Family Physicians, 2005, POL REC PER HLTH EX
[Anonymous], 2007 NAT SURV CHILDR
Bailey DB, 2009, PEDIATRICS, V124, P527, DOI 10.1542/peds.2008-2992
Bethell C, 2011, PEDIATRICS, V128, P146, DOI 10.1542/peds.2010-0424
Bethell CD, 2002, AMBUL PEDIATR, V2, P38, DOI 10.1367/1539-4409(2002)002<0038:ICWSHC>2.0.CO;2
Bethell CD, 2011, ACAD PEDIATR, V11, pS22, DOI 10.1016/j.acap.2010.08.011
Blumberg SJ, 2009, DESIGN OPERATION NAT
Coker T, 2011, PEDIATRICS, V125, P1159
Committee on Practice and Ambulatory Medicine and Bright Futures Steering Committee, 2007, PEDIATRICS, V120, P1376, DOI DOI 10.1542/PEDS.2007-2901
Duby JC, 2006, PEDIATRICS, V118, P405, DOI 10.1542/peds.2006-1231
Forepath, PEDS PAR EV DEV STAT
Glascoe FP, 1997, PEDIATRICS, V99, P522, DOI 10.1542/peds.99.4.522
Glascoe FP, 2003, CLIN PEDIATR, V42, P133, DOI 10.1177/000992280304200206
Guerrero AD, 2010, ACAD PEDIATR, V10, P400, DOI 10.1016/j.acap.2010.08.008
Guerrero AD, 2011, PEDIATRICS, V128, P901, DOI 10.1542/peds.2011-0030
Hagan J., 2008, GUIDELINES HLTH SUPE
Halfon N, 2004, PEDIATRICS, V113, P1926
Homer CJ, 2008, PEDIATRICS, V122, pE922, DOI 10.1542/peds.2007-3762
LOCK TM, 1986, J DEV BEHAV PEDIATR, V7, P340
Mandell DS, 2002, J AM ACAD CHILD PSY, V41, P1447, DOI 10.1097/01.CHI.0000024863.60748.53
Mandell DS, 2005, PEDIATRICS, V116, P1480, DOI 10.1542/peds.2005-0185
Mann JR, 2008, DISABIL HEALTH J, V1, P157, DOI 10.1016/j.dhjo.2008.04.002
McPherson M, 1998, PEDIATRICS, V102, P137, DOI 10.1542/peds.102.1.137
Nunnally J. C., 1994, PSYCHOMETRIC THEORY
PALFREY JS, 1987, J PEDIATR-US, V111, P651, DOI 10.1016/S0022-3476(87)80238-X
Radecki L, 2011, PEDIATRICS, V128, P14, DOI 10.1542/peds.2010-2180
Raphael JL, 2009, ACAD PEDIATR, V9, P221, DOI 10.1016/j.acap.2009.01.011
Rosenberg SA, 2008, PEDIATRICS, V121, pE1503, DOI 10.1542/peds.2007-1680
Simpson GA, 2003, PAEDIATR PERINAT EP, V17, P68, DOI 10.1046/j.1365-3016.2003.00459.x
Strickland BB, 2011, PEDIATRICS, V127, P604, DOI 10.1542/peds.2009-3555
United States Preventive Services Task Force, 2002, GUID CLIN PREV SERV, V2nd & 3rd
Yeargin-Allsopp M, 2003, JAMA-J AM MED ASSOC, V289, P49, DOI 10.1001/jama.289.1.49
Zuckerman KE, 2009, ACAD PEDIATR, V9, P97, DOI 10.1016/j.acap.2008.12.006
NR 33
TC 5
Z9 5
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1876-2859
J9 ACAD PEDIATR
JI Acad. Pediatr.
PD SEP-OCT
PY 2012
VL 12
IS 5
BP 384
EP 390
PG 7
WC Pediatrics
SC Pediatrics
GA 013KV
UT WOS:000309305200008
PM 22819200
ER
PT J
AU Fiks, AG
Mayne, S
Hughes, CC
DeBartolo, E
Behrens, C
Guevara, JP
Power, T
AF Fiks, Alexander G.
Mayne, Stephanie
Hughes, Cayce C.
DeBartolo, Elena
Behrens, Carina
Guevara, James P.
Power, Thomas
TI Development of an Instrument to Measure Parents' Preferences and Goals
for the Treatment of Attention Deficit-Hyperactivity Disorder
SO ACADEMIC PEDIATRICS
LA English
DT Article
DE ADHD; patient preference; practice-based research; shared decision
making
ID DEFICIT/HYPERACTIVITY-DISORDER; PSYCHOMETRIC PROPERTIES;
AFRICAN-AMERICAN; RATING-SCALE; CHILDREN; ADHD; INTERVENTIONS;
MEDICATION; NUMBER; ACCEPTABILITY
AB OBJECTIVES: To describe the development and validation of an instrument to measure parents' attention deficit hyperactivity disorder (ADHD) treatment preferences and goals.
METHODS: Parents of children 6 to 12 years of age diagnosed with ADHD in the past 18 months were recruited from 8 primary care sites and an ADHD treatment center (autism excluded). A 16-item medication, 15-item behavior therapy preference scale and a 23-item goal scale, were developed after a review of the literature, 90 parent and clinician semistructured interviews, and input from parent advocates and professional experts were administered to parents. Parent cognitive interviews confirmed item readability, clarity, content, and response range. We conducted an exploratory factor analysis and assessed internal consistency and test-retest reliability and construct and concurrent validity.
RESULTS: We recruited 237 parents (mean child age 8.1 years, 51% black, 59% from primary care, 61% of children medication naive). Factor analyses identified 4 medication preference subscales (treatment acceptability, feasibility, stigma, and adverse effects, Cronbach's alpha 0.74-0.87); 3 behavior therapy subscales (treatment acceptability, feasibility, and adverse effects, alpha 0.76-0.83); and 3 goal subscales (academic achievement, behavioral compliance, and interpersonal relationships, alpha 0.83-0.86). The most strongly endorsed goal was academic achievement. The scales demonstrated construct validity, concurrent validity (r = 0.3-0.6) compared with the Treatment Acceptability Questionnaire and Impairment Rating Scale and moderate to excellent test-retest reliability (intraclass coefficient = 0.7-0.9).
CONCLUSIONS: We developed a valid and reliable instrument for measuring preferences and goals for ADHD treatment, which may help clinicians more easily comply with new national treatment guidelines for ADHD that emphasize shared decision making.
C1 [Fiks, Alexander G.; Mayne, Stephanie] Univ Penn, Pediat Res Consortium PeRC, Philadelphia, PA 19104 USA.
[Fiks, Alexander G.; Mayne, Stephanie; Hughes, Cayce C.; DeBartolo, Elena; Behrens, Carina] Univ Penn, Ctr Biomed Informat CBMI, Philadelphia, PA 19104 USA.
[Fiks, Alexander G.; Mayne, Stephanie; Hughes, Cayce C.; DeBartolo, Elena; Behrens, Carina; Guevara, James P.] Univ Penn, Ctr Pediat Clin Effectiveness, Philadelphia, PA 19104 USA.
[Fiks, Alexander G.; Mayne, Stephanie; Hughes, Cayce C.; DeBartolo, Elena; Behrens, Carina; Guevara, James P.] Univ Penn, PolicyLab, Philadelphia, PA 19104 USA.
[Fiks, Alexander G.; Guevara, James P.; Power, Thomas] Univ Penn, Childrens Hosp Philadelphia, Dept Pediat, Philadelphia, PA 19104 USA.
[Power, Thomas] Univ Penn, Dept Psychiat, Perelman Sch Med, Philadelphia, PA 19104 USA.
RP Fiks, AG (reprint author), Childrens Hosp Philadelphia, Pediat Generalist Res Grp, 3535 Market Suite,Room 1546, Philadelphia, PA 19104 USA.
EM fiks@email.chop.edu
FU Eunice Kennedy Shriver National Institute of Child Health & Human
Development [K23HD059919]
FX We thank Fran Barg, James Massey, the clinicians at CHOP's ADHD Center,
Mark Ramos, and Russell Localio for their help with the conduct and
analysis of this research. Marie Paxson of Children and Adults with
Attention Deficit/Hyperactivity Disorder provided advice to the research
team and reviewed the scales. We also thank the network of primary care
physicians, the patients, and the families for their contributions to
clinical research through the Pediatric Research Consortium at The
Children's Hospital of Philadelphia. This research was supported by
Award Number K23HD059919 from the Eunice Kennedy Shriver National
Institute of Child Health & Human Development. The content is solely the
responsibility of the authors and does not necessarily represent the
official views of the Eunice Kennedy Shriver National Institute of Child
Health & Human Development or the National Institutes of Health.
CR Wolraich M, 2011, PEDIATRICS, V128, P1007, DOI 10.1542/peds.2011-2654
American Academy of Pediatrics Task Force on Mental Health, 2011, CAR CHILDR ADHD RES
[Anonymous], 2005, MMWR, V54, P842
Bauermeister JJ, 2003, J AM ACAD CHILD PSY, V42, P851, DOI 10.1097/01.CHI.0000046864.56865.30
Bennett DS, 1996, J PEDIATR PSYCHOL, V21, P643, DOI 10.1093/jpepsy/21.5.643
Bosworth H, 2006, PATIENT TREATMENT AD
Browne MW, 2001, MULTIVAR BEHAV RES, V36, P111, DOI 10.1207/S15327906MBR3601_05
Bussing R, 2005, J CHILD ADOL PSYCHOP, V15, P78, DOI 10.1089/cap.2005.15.78
Bussing R, 1998, SOC SCI MED, V46, P919, DOI 10.1016/S0277-9536(97)00219-0
Bussing R, 2003, SOC PSYCH PSYCH EPID, V38, P563, DOI 10.1007/s00127-003-0674-8
CATTELL RB, 1966, MULTIVAR BEHAV RES, V1, P245, DOI 10.1207/s15327906mbr0102_10
Charles C, 1997, SOC SCI MED, V44, P681, DOI 10.1016/S0277-9536(96)00221-3
COHEN J, 1992, PSYCHOL BULL, V112, P155, DOI 10.1037/0033-2909.112.1.155
CRONBACH LJ, 1951, PSYCHOMETRIKA, V16, P297
Cunningham CE, 2007, AMBUL PEDIATR, V7, P60, DOI 10.1016/j.ambp.2006.05.003
DuPaul GJ, 1998, ADHD RAT SCAL 4 CHEC
Fabiano GA, 2006, J CLIN CHILD ADOLESC, V35, P369, DOI 10.1207/s15374424jccp3503_3
Fiks AG, 2010, PEDIATRICS, V127, pe188
Gorsuch R. L., 2003, HDB PSYCHOL RES METH, V2, P143
Guevara JP, 2005, PEDIATRICS, V116, pE512, DOI 10.1542/peds.2005-0243d
Habel LA, 2005, J CHILD ADOL PSYCHOP, V15, P62, DOI 10.1089/cap.2005.15.62
Hawley KM, 2003, J CONSULT CLIN PSYCH, V71, P62, DOI 10.1037/0022-006X.71.1.62
HORN JL, 1965, PSYCHOMETRIKA, V30, P179, DOI 10.1007/BF02289447
Horn JL, 1979, PSYCHOL METHODS, V1, P345
Institute of Medicine (US), 2009, COMM COMP EFF RES PR
Kaufman J, 1997, J AM ACAD CHILD PSY, V36, P980, DOI 10.1097/00004583-199707000-00021
KAZDIN AE, 1980, J APPL BEHAV ANAL, V13, P259, DOI 10.1901/jaba.1980.13-259
Krain Amy L, 2005, J Atten Disord, V9, P425, DOI 10.1177/1087054705279996
LeFever GB, 1999, AM J PUBLIC HEALTH, V89, P1359, DOI 10.2105/AJPH.89.9.1359
Leslie LK, 2007, J DEV BEHAV PEDIATR, V28, P179, DOI 10.1097/DBP.0b013e3180324d9a
Little RJ, 1986, STAT ANAL MISSING DA
Loe IM, 2007, AMBUL PEDIATR, V7, P82, DOI 10.1016/j.ambp.2006.05.005
McMaster University Evidence-Based Practice Center, 1999, TREATM ATT DEF HYP D
O'Connor A. M., 2000, USER MANUAL STAGE DE
O'Connor AM, 2009, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD001431.pub2
Olaniyan O, 2007, AMBUL PEDIATR, V7, P226, DOI 10.1016/j.ambp.2007.02.002
Olfson M, 2003, AM J PSYCHIAT, V160, P1071, DOI 10.1176/appi.ajp.160.6.1071
Pappadopulos E, 2009, J AM ACAD CHILD PSY, V48, P501, DOI 10.1097/CHI.0b013e31819c23ed
Pelham WE, 2008, J CLIN CHILD ADOLESC, V37, P184, DOI 10.1080/15374410701818681
Perwien Amy, 2004, J Manag Care Pharm, V10, P122
Power TJ, 2009, CURR PSYCHIAT REP, V11, P407
Reynolds C. R., 1992, BEHAV ASSESSMENT SYS
Saylor K, 2007, J CHILD ADOL PSYCHOP, V17, P831, DOI 10.1089/cap.2007.0030
Saylor KE, 2002, J CLIN PSYCHIAT, V63, P23
SIDAK Z, 1967, J AM STAT ASSOC, V62, P626, DOI 10.2307/2283989
Singh Ilina, 2007, Clin Child Psychol Psychiatry, V12, P167, DOI 10.1177/1359104507075920
Streiner D, 2003, HLTH MEASUREMENT SCA
The MTA Cooperative Group. Multimodal Treatment Study of Children with ADHD, 1999, ARCH GEN PSYCHIAT, V56, P1073
VELICER WF, 1976, PSYCHOMETRIKA, V41, P321, DOI 10.1007/BF02293557
Wegener D. T., 2000, HDB RES METHODS SOCI, P412
Winer BJ, 1991, STAT PRINCIPLES EXPT
Wolraich ML, 1998, J ABNORM CHILD PSYCH, V26, P141, DOI 10.1023/A:1022673906401
Wolraich ML, 2003, J PEDIATR PSYCHOL, V28, P559, DOI 10.1093/jpepsy/jsg046
Zito JM, 2005, PSYCHIAT SERV, V56, P157, DOI 10.1176/appi.ps.56.2.157
NR 54
TC 5
Z9 5
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1876-2859
J9 ACAD PEDIATR
JI Acad. Pediatr.
PD SEP-OCT
PY 2012
VL 12
IS 5
BP 445
EP 455
PG 11
WC Pediatrics
SC Pediatrics
GA 013KV
UT WOS:000309305200016
PM 22748759
ER
PT J
AU Jimenez, L
Recio, S
Mendez, A
Lorda, MJ
Permuy, B
Mendez, C
AF Jimenez, Luis
Recio, Sergio
Mendez, Amavia
Jose Lorda, Maria
Permuy, Beatriz
Mendez, Castor
TI Automatic imitation and spatial compatibility in a key-pressing task
SO ACTA PSYCHOLOGICA
LA English
DT Article
DE Automatic imitation; Spatial compatibility effects; Human mirror system
ID AUTISM SPECTRUM CONDITIONS; INTRANSITIVE ACTIONS; MODULATION; MOVEMENTS
AB Automatic imitation has been often confounded with spatial compatibility effects. Heyes (2011) called attention to this confound, and proposed some criteria which must be satisfied before these effects could be unequivocally taken to be an index of the functioning of the human mirror system. Evidence satisfying such criteria has been reported by Catmur and Heyes (2011), using a relatively unfamiliar finger abduction movement. However, because many previous studies relied on more familiar actions, we aimed at testing whether analogous effects could be obtained with a more practiced key-pressing task. In Experiment 1, we used anatomical controls (i.e., views of right vs. left hands) under conditions affording mirror imitation, and showed that spatial compatibility masked the effects of automatic imitation. Experiment 2 used rotated conditions to control for this spatial-anatomical confound, and it showed unequivocal effects of automatic imitation, which were obtained regardless of its relation to the spatial stimulus-response mapping. These results cast some doubts on the interpretation of previous reports relying exclusively on scenes presented from a mirror perspective, and suggest the convenience of using both rotated scenes and anatomical controls in order to assess automatic imitation. (C) 2012 Elsevier B.V. All tights reserved.
C1 [Jimenez, Luis] Univ Santiago de Compostela, Fac Psicol, Santiago De Compostela 15782, Spain.
RP Jimenez, L (reprint author), Univ Santiago de Compostela, Fac Psicol, Santiago De Compostela 15782, Spain.
EM luis.jimenez@usc.es
RI Jimenez, Luis/C-6050-2011
OI Jimenez, Luis/0000-0002-0763-4220
CR Aicken MD, 2007, BRAIN COGNITION, V63, P304, DOI 10.1016/j.bandc.2006.09.005
Bertenthal BI, 2006, J EXP PSYCHOL HUMAN, V32, P210, DOI 10.1037/0096-1523.32.2.210
Boyer T. W., 2009, P 31 ANN C COGN SCI, P2280
Brass M, 2001, ACTA PSYCHOL, V106, P3, DOI 10.1016/S0001-6918(00)00024-X
Brass M, 2009, PHILOS T R SOC B, V364, P2359, DOI 10.1098/rstb.2009.0066
Brass M, 2005, TRENDS COGN SCI, V9, P489, DOI 10.1016/j.tics.2005.08.007
Brass M, 2000, BRAIN COGNITION, V44, P124, DOI 10.1006/brcg.2000.1225
Calvo-Merino B, 2005, CEREB CORTEX, V15, P1243, DOI 10.1093/cercor/bhi007
Calvo-Merino B, 2010, PSYCHOL RES-PSYCH FO, V74, P400, DOI 10.1007/s00426-009-0262-y
Catmur C, 2011, J EXP PSYCHOL HUMAN, V37, P409, DOI 10.1037/a0019325
Cook J, 2011, EXP BRAIN RES, V211, P601, DOI 10.1007/s00221-011-2584-4
Cook JL, 2012, J AUTISM DEV DISORD, V42, P1045, DOI 10.1007/s10803-011-1341-7
Heyes C, 2011, PSYCHOL BULL, V137, P463, DOI 10.1037/a0022288
Heyes C, 2001, TRENDS COGN SCI, V5, P253, DOI 10.1016/S1364-6613(00)01661-2
Hill EL, 2004, TRENDS COGN SCI, V8, P26, DOI 10.1016/j.tics.2003.11.003
Iacoboni M, 2009, ANNU REV PSYCHOL, V60, P653, DOI 10.1146/annurev.psych.60.110707.163604
Iacoboni M, 1999, SCIENCE, V286, P2526, DOI 10.1126/science.286.5449.2526
Jansson E, 2007, EXP BRAIN RES, V182, P549, DOI 10.1007/s00221-007-1013-1
Koski L, 2003, J NEUROPHYSIOL, V89, P460, DOI 10.1152/jn.00248.2002
Longo MR, 2009, EXP BRAIN RES, V192, P739, DOI 10.1007/s00221-008-1649-5
Longo MR, 2008, J EXP PSYCHOL HUMAN, V34, P489, DOI 10.1037/0096-1523.34.2.489
Meltzoff A. N., 2002, IMITATIVE MIND DEV E, P19, DOI DOI 10.1017/CBO9780511489969.002
Press C, 2008, BRAIN COGNITION, V67, P44, DOI 10.1016/j.bandc.2007.11.001
Press C, 2005, COGNITIVE BRAIN RES, V25, P632, DOI 10.1016/j.cogbrainres.2005.08.020
Prinz W., 2002, IMITATIVE MIND DEV E, P143, DOI 10.1017/CBO9780511489969.009
Prinz W, 1997, EUR J COGN PSYCHOL, V9, P129, DOI 10.1080/713752551
Sauser EL, 2006, NEURAL NETWORKS, V19, P285, DOI 10.1016/j.neunet.2006.02.003
Spengler S, 2010, BIOL PSYCHIAT, V68, P1148, DOI 10.1016/j.biopsych.2010.09.017
Sturmer B, 2000, J EXP PSYCHOL HUMAN, V26, P1746, DOI 10.1037//0096-1523.26.6.1746
WEEKS DJ, 1990, J EXP PSYCHOL GEN, V119, P355, DOI 10.1037/0096-3445.119.4.355
NR 30
TC 5
Z9 5
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0001-6918
J9 ACTA PSYCHOL
JI Acta Psychol.
PD SEP
PY 2012
VL 141
IS 1
BP 96
EP 103
DI 10.1016/j.actpsy.2012.07.007
PG 8
WC Psychology, Experimental
SC Psychology
GA 013TS
UT WOS:000309329400013
PM 22864312
ER
PT J
AU Perez, DR
Galindo, LM
Pison, JL
Delgado, RP
Hidalgo, ML
Segura, JLP
Gallart, MDM
Valle, AR
Martin, YMTC
AF Royo Perez, D.
Monge Galindo, L.
Lopez Pison, J.
Perez Delgado, R.
Lafuente Hidalgo, M.
Pena Segura, J. L.
Miramar Gallart, M. D.
Rodriguez Valle, A.
Calvo Martin, M. T.
TI Prader-willi and angelman syndromes: 21 years of experience
SO ANALES DE PEDIATRIA
LA Spanish
DT Article
DE Genomic imprinting; Deletion; Uniparental dysomy; Genetic counselling;
Methylation
ID NEUROPAEDIATRIC ATTENTION; UNIPARENTAL DISOMY; DEMAND; NEUROPEDIATRICS;
BEHAVIOR; DELETION; ADULTS
AB Introduction: Prader-Willi syndrome (PWS) and Angelman syndrome (AS) were the first syndromes in humans that were known to originate from the phenomenon of the genomic imprinting. We review our experience of 21 years with PWS and AS that were confirmed with the genetically.
Results: Of the 13,875 patients recorded during the study period, 11 were diagnosed with PWS (18%), 7 males (63.6%) and 4 females (36.4%), with a mean age of 9.06 years (+/- 6.92, range: 0.68-21.6). The time of the follow up of this group was 3.83 years (+/- 4.03, range: 0.49-15.3), and the age at diagnosis was 4.4 years (+/- 6.84, range: 0.03-19.38). Almost three quarters (72.7% of the PWS patients had a uniparental dysomy and 27.3% a paternal deletion. Six patients (8%) were diagnosed with AS, 4 females (66.6%) and 2 males (33.4%), with a mean age of 14.65 years (+/- 11.89, range: 1.3-30.7). The time of follow up was 6.76 years (+/- 5.89,range: 0.16-15), and the age at diagnosis was 8.84 years (+/- 9.11, range: 1.10-23). A maternal deletion was present in 83.3% of the AS patients and 16.7% had a maternal dysomy.
Discussion: As genetic advances are made these pathologies are confirmed before. Unlike the data in the literature, in our series most patients diagnosed with PWS (72'3%) had uniparental disomy. Recent studies correlation genotype with phenotype, in PWS is more serious if it occurs a deletion and in SA is milder in the case of uniparental disomy.
Conclusions: Genetic studies must be performed in view of the established clinical symptoms: neonatal hypotonia of unknown cause in PWS and psychomotor deficits with autism features, particularly associated with epilepsy, must be evaluated in AS to prevent diagnostic uncertainties, unnecessary complementary examinations and to provide early genetic counselling. (C) 2011 Asociacion Espanola de Pediatria. Published by Elsevier Espana, S.L. All rights reserved.
C1 [Royo Perez, D.; Monge Galindo, L.; Lopez Pison, J.; Perez Delgado, R.; Lafuente Hidalgo, M.; Pena Segura, J. L.] Hosp Univ Miguel Servet, Secc Neuropediat, Zaragoza, Spain.
[Monge Galindo, L.; Lopez Pison, J.; Perez Delgado, R.; Lafuente Hidalgo, M.; Pena Segura, J. L.] Hosp Univ Miguel Servet, Inst Aragones Ciencias Salud, Grp Invest Neurometabol, Zaragoza, Spain.
[Miramar Gallart, M. D.; Rodriguez Valle, A.; Calvo Martin, M. T.] Hosp Univ Miguel Servet, Serv Genet, Zaragoza, Spain.
RP Pison, JL (reprint author), Hosp Univ Miguel Servet, Secc Neuropediat, Zaragoza, Spain.
EM jtopezpi@salud.aragon.es
CR Cassidy SB, 1996, AM J HUM GENET, V58, P1085
Amos-Landgraf JM, 1999, AM J HUM GENET, V65, P370, DOI 10.1086/302510
Artigas Pallares J, 2011, TRASTORNOS NEURODESA, P123
Beckung E, 2004, DEV MED CHILD NEUROL, V46, P239, DOI 10.1017/S0012162204000398
Campos-Castello J, 1999, REV NEUROLOGIA, V28, P69
Cassidy SB, 1998, MEDICINE, V77, P140, DOI 10.1097/00005792-199803000-00005
Clayton-Smith J, 2003, J MED GENET, V40, P87, DOI 10.1136/jmg.40.2.87
Dykens EM, 1999, AM J MENT RETARD, V104, P67, DOI 10.1352/0895-8017(1999)104<0067:MBDIPS>2.0.CO;2
GREENSWAG LR, 1987, DEV MED CHILD NEUROL, V29, P145
Gross-Tsur V, 2001, J CHILD NEUROL, V16, P288, DOI 10.1177/088307380101600411
HOLM VA, 1993, PEDIATRICS, V91, P398
Hoybye C, 2002, J CLIN ENDOCR METAB, V87, P3590, DOI 10.1210/jc.87.8.3590
Lopez-Pison J, 1997, REV NEUROLOGIA, V25, P1896
LopezPison J, 1997, REV NEUROLOGIA, V25, P1685
Lopez-Pison J, 1998, REV NEUROLOGIA, V26, P208
Lopez-Pison J, 1997, REV NEUROLOGIA, V25, P1905
LopezPison J, 1997, REV NEUROLOGIA, V25, P1535
Lossie AC, 2001, J MED GENET, V38, P83445
Moncla A, 1999, EUR J HUM GENET, V7, P131, DOI 10.1038/sj.ejhg.5200258
Smith A, 1997, J MED GENET, V34, P426, DOI 10.1136/jmg.34.5.426
Williams CA, 2005, BRAIN DEV-JPN, V27, P88, DOI 10.1016/j.braindev.2003.09.014
NR 21
TC 0
Z9 0
PU EDICIONES DOYMA S A
PI BARCELONA
PA TRAV DE GRACIA 17-21, 08021 BARCELONA, SPAIN
SN 1695-4033
J9 AN PEDIATR
JI An. Pediatr.
PD SEP
PY 2012
VL 77
IS 3
BP 151
EP 157
DI 10.1016/j.anpedi.2012.01.021
PG 7
WC Pediatrics
SC Pediatrics
GA 013JI
UT WOS:000309301300002
ER
PT J
AU Garcia-Ron, G
Carratala, F
Andreo-Lillo, P
Mestre-Ricote, JL
Moya, M
AF Garcia-Ron, G.
Carratala, F.
Andreo-Lillo, P.
Mestre-Ricote, J. L.
Moya, M.
TI Early clinical indicators of pervasive development disorders
SO ANALES DE PEDIATRIA
LA Spanish
DT Article
DE Autism; Diagnosis; Infancy; Outcome; Pervasive development disorders;
Toddlers
ID AUTISM SPECTRUM DISORDER; MODIFIED CHECKLIST; TODDLERS; CHILDREN;
SENSITIVITY
AB Introduction: Pervasive development disorders (PDD) conditions characterised by deficits in many areas of behaviour, such as delay in social interactions, abnormalities in verbal and non-verbal communication, and the presence of the restrictive and repetitive interests. The relevance of early diagnosis is based on the fact that early intervention could have a beneficial effect on the long term outcome. Due to the increase of the PDD diagnosis in the recent years, we aimed to study easily detectable clinical traits during the first year of life, leading to an improvement in the diagnosis.
Patients and interventions: A prospective and retrospective study was conducted on 37 PDD patients and 69 healthy controls. Somatometric and neurological examinations were performed and a questionnaire with several variables from the Modified Checklist for Autism in Toddlers (M-CHAT) completed by the parents.
Results: The male to female ratio (OR: 3.87; 95% CI: 1.23-12.96), delay in the first disyllabic words (PDD = 20.1 +/- 23 months vs Control = 10.8 +/- 10.3 months; P < .01), absence of visual contact (OR: 0.05; 95% CI: 0.01-0.29), the lack of response to attention call (OR: 0.12; 95% CI: 0.02-0.67), and the increase in tantrums (OR: 6.37; 95% CI: 2.39-17.34), were significantly higher in the PDD group.
Conclusions: The differences detected between groups can not been considered as a diagnostic tool of certainty in this time period, however, we believe that they should be considered in the context of maturational delay, as alarm signs in infants and toddlers, as well as suggesting the existence of an early pervasive development phenotype. (C) 2011 Asociacion Espanola de Pediatria. Published by Elsevier Espana, S.L. All rights reserved.
C1 [Garcia-Ron, G.; Carratala, F.; Andreo-Lillo, P.] Hosp Univ San Juan Alicante, Unidad Neuropediat, Alacant, Spain.
[Mestre-Ricote, J. L.; Moya, M.] Hosp Univ San Juan Alicante, Unidad Neonatal, Alacant, Spain.
RP Carratala, F (reprint author), Hosp Univ San Juan Alicante, Unidad Neuropediat, Alacant, Spain.
EM fcarratala@saludalia.com
CR Artigas-Pallares J, 2007, REV NEUROLOGIA, V44, P739
Blampied M, 2010, BRIT J DEV PSYCHOL, V28, P483, DOI 10.1348/026151009X467621
Bryant J, 2007, PEDIATRICS ED ESP, V63, P1
Carratala Marco F, 2006, REV ESP PEDIAT, V62, P235
Cermak SA, 2010, J AM DIET ASSOC, V110, P238, DOI 10.1016/j.jada.2009.10.032
Charman T, 2001, J AUTISM DEV DISORD, V31, P145, DOI 10.1023/A:1010790813639
Diaz-Atienza F, 2004, REV PSIQUIATRIA PSIC, V4, P127
DSM-I.V, 1995, DSM I V MANUAL DIAGN
Fischer F, 2005, ARCH PEDIAT ADOL MED, V159, P691, DOI 10.1001/archpedi.159.7.691-a
Hernandez JM, 2005, REV NEUROLOGIA, V41, P237
Iverson JM, 2007, J AUTISM DEV DISORD, V37, P158, DOI 10.1007/s10803-006-0339-z
Limon A, 2007, GAC MED MEX, V143, P73
Magallon S, 2009, AN PEDIATR, V70, P562, DOI 10.1016/j.anpedi.2009.01.018
Millá M G, 2009, Rev Neurol, V48 Suppl 2, pS47
Pickles A, 2009, J CHILD PSYCHOL PSYC, V50, P843, DOI 10.1111/j.1469-7610.2008.02032.x
Robins DL, 2001, J AUTISM DEV DISORD, V31, P131, DOI 10.1023/A:1010738829569
Ruggieri V, 2007, MEDICINA-BUENOS AIRE, V67, P569
VIZCAINO CN, 2008, AN PEDIATR, V68, P149
NR 18
TC 0
Z9 0
PU EDICIONES DOYMA S A
PI BARCELONA
PA TRAV DE GRACIA 17-21, 08021 BARCELONA, SPAIN
SN 1695-4033
J9 AN PEDIATR
JI An. Pediatr.
PD SEP
PY 2012
VL 77
IS 3
BP 171
EP 175
DI 10.1016/j.anpedi.2011.08.013
PG 5
WC Pediatrics
SC Pediatrics
GA 013JI
UT WOS:000309301300005
PM 22444581
ER
PT J
AU White, SW
Kreiser, NL
Pugliese, C
Scarpa, A
AF White, Susan Williams
Kreiser, Nicole L.
Pugliese, Cara
Scarpa, Angela
TI Social anxiety mediates the effect of autism spectrum disorder
characteristics on hostility in young adults
SO AUTISM
LA English
DT Article
DE autism; adult; social anxiety; hostility; aggression
ID HIGH-FUNCTIONING CHILDREN; ASPERGER-SYNDROME; GENERAL-POPULATION; PEER
REJECTION; QUOTIENT AQ; SELF-ESTEEM; ADOLESCENTS; AGGRESSION;
LONELINESS; PHENOTYPE
AB Problems with social anxiety are frequently reported in people with autism spectrum disorders (ASD). It is possible that social anxiety, when present, exacerbates the experience of hostility and other forms of aggression in relation to ASD symptoms. This study sought to determine if social anxiety symptoms mediate the relationship between features of ASD and feelings of hostility in young adults. Self-report measures of social anxiety, ASD, and facets of aggression were collected in a non-clinical sample (n = 618) of college students. Social anxiety was found to partially mediate the relationship between ASD features and self-reported hostility. There was also evidence for inconsistent mediation, such that social anxiety dampened the strength of the relationship between ASD symptoms and verbal and physical aggression. Findings highlight the potential influence of associated psychiatric symptoms in people with ASD. In addition, dimensional conceptualization of ASD symptoms, as opposed to a categorical approach solely, may be a useful approach to studying complex personality processes.
C1 [White, Susan Williams; Kreiser, Nicole L.; Pugliese, Cara; Scarpa, Angela] Virginia Tech, Blacksburg, VA 24061 USA.
RP White, SW (reprint author), Virginia Polytech Inst & State Univ, 109 Williams Hall, Blacksburg, VA 24061 USA.
EM sww@vt.edu
CR Abell F, 2005, AUTISM, V9, P515, DOI 10.1177/1362361305057857
Amaral DG, 2003, GENES BRAIN BEHAV, V2, P295, DOI 10.1034/j.1601-183X.2003.00043.x
Attwood T., 2007, COMPLETE GUIDE ASPER
Austin EJ, 2005, PERS INDIV DIFFER, V38, P451, DOI 10.1016/j.paid.2004.04.022
BARON RM, 1986, J PERS SOC PSYCHOL, V51, P1173, DOI 10.1037/0022-3514.51.6.1173
Baron-Cohen S, 2001, J AUTISM DEV DISORD, V31, P5, DOI 10.1023/A:1005653411471
Bauminger N, 2000, CHILD DEV, V71, P447, DOI 10.1111/1467-8624.00156
Beidel D. C., 2007, SHY CHILDREN PHOBIC
Bellini S, 2006, FOCUS AUTISM OTHER D, V21, P138, DOI DOI 10.1177/10883576060210030201
Blackshaw AJ, 2001, AUTISM, V5, P147, DOI 10.1177/1362361301005002005
Burnette CP, 2005, J AUTISM DEV DISORD, V35, P63, DOI 10.1007/s10803-004-1035-5
BUSS AH, 1992, J PERS SOC PSYCHOL, V63, P452, DOI 10.1037//0022-3514.63.3.452
Clark D. M., 2001, INT HDB SOCIAL ANXIE, P405
Constantino JN, 2005, BIOL PSYCHIAT, V57, P655, DOI 10.1016/j.biopsych.2004.12.014
Constantino JN, 2003, ARCH GEN PSYCHIAT, V60, P524, DOI 10.1001/archpsyc.60.5.524
CRICK NR, 1994, PSYCHOL BULL, V115, P74, DOI 10.1037/0033-2909.115.1.74
Crozier W. R., 2001, INT HDB SOCIAL ANXIE, P1
DeWall CN, 2010, J ANXIETY DISORD, V24, P260, DOI 10.1016/j.janxdis.2009.12.002
Dodge KA, 2003, CHILD DEV, V74, P374, DOI 10.1111/1467-8624.7402004
Fairchild AJ, 2009, PREV SCI, V10, P87, DOI 10.1007/s11121-008-0109-6
Farmer CA, 2011, RES AUTISM SPECT DIS, V5, P317, DOI 10.1016/j.rasd.2010.04.014
Garson G. D., 2011, STATNOTES TOPICS MUL
Ghaziuddin M, 2005, MENTAL HLTH ASPECTS
Hill EL, 2004, TRENDS COGN SCI, V8, P26, DOI 10.1016/j.tics.2003.11.003
Hofvander B, 2009, BMC PSYCHIATRY, V9, DOI 10.1186/1471-244X-9-35
Honda H, 2005, DEV MED CHILD NEUROL, V47, P10, DOI 10.1017/S0012162205000034
Howlin P, 2000, AUTISM, V4, P63, DOI DOI 10.1177/1362361300004001005
Jobe LE, 2007, PERS INDIV DIFFER, V42, P1479, DOI 10.1016/j.paid.2006.10.021
Kachin KE, 2001, BEHAV THER, V32, P479, DOI 10.1016/S0005-7894(01)80032-0
Kashdan TB, 2009, BEHAV RES THER, V47, P559, DOI 10.1016/j.brat.2009.03.010
Klin A., 2005, HDB AUTISM PERVASIVE
Kunihira Y, 2006, J AUTISM DEV DISORD, V36, P553, DOI 10.1007/s10803-006-0094-1
Kuusikko S, 2008, J AUTISM DEV DISORD, V38, P1697, DOI 10.1007/s10803-008-0555-9
Laurent AC, 2004, TOP LANG DISORD, V24, P286
Leary MR, 2006, PERS SOC PSYCHOL REV, V10, P111, DOI 10.1207/s15327957pspr1002_2
MacKinnon D P, 2000, Prev Sci, V1, P173, DOI 10.1023/A:1026595011371
MacKinnon DP, 2007, ANNU REV PSYCHOL, V58, P593, DOI 10.1146/annurev.psych.58.110405.085542
Melfsen S, 2006, EUR CHILD ADOLES PSY, V15, P111, DOI 10.1007/s00787-006-0510-2
Meyer JA, 2006, AUTISM, V10, P383, DOI 10.1177/1362361306064435
Mohlman J, 2007, BEHAV RES THER, V45, P591, DOI 10.1016/j.brat.2006.03.007
Myles BS, 2003, CHILD ADOL PSYCH CL, V12, P123, DOI 10.1016/S1056-4993(02)00048-2
Novaco R. W., 2003, NOVACO ANGER SCALE P
Piven J, 1999, AM J PSYCHIAT, V156, P557
Preacher KJ, 2004, BEHAV RES METH INS C, V36, P717, DOI 10.3758/BF03206553
Pugliese C, 2011, SOCIAL ANXIETY UNPUB
Reijntjes A, 2011, PERS SOC PSYCHOL B, V37, P955, DOI 10.1177/0146167211410247
Research Units on Pediatric Psychopharmacology Autism Network, 2002, NEW ENGLAND J MED, V347, P314
Roberson-Nay R, 2007, PSYCHOL ASSESSMENT, V19, P133, DOI 10.1037/1040-3590.19.1.133
Rosbrook A, 2010, RES AUTISM SPECT DIS, V4, P415, DOI 10.1016/j.rasd.2009.10.012
Ryden E, 2008, CLIN NEUROPSYCHIATRY, V5, P13
Sebastian C, 2009, J AUTISM DEV DISORD, V39, P1122, DOI 10.1007/s10803-009-0725-4
Sofronoff K, 2007, J AUTISM DEV DISORD, V37, P1203, DOI 10.1007/s10803-006-0262-3
Sukhodolsky DG, 2008, J ABNORM CHILD PSYCH, V36, P117, DOI 10.1007/s10802-007-9165-9
Tantam D, 2003, CHILD ADOL PSYCH CL, V12, P143, DOI 10.1016/S1056-4993(02)00053-6
Turner S. M., 1996, SOCIAL PHOBIA ANXIET
Turner S. M., 1989, PSYCHOL ASSESSMENT J, V1, P35, DOI [10.1037/1040-3590.1.1.35, DOI 10.1037/1040-3590.1.1.35]
United States Centers for Disease Control and Prevention, 2009, MMWR, V58
Verte S, 2006, J AUTISM DEV DISORD, V36, P351, DOI 10.1007/s10803-006-0074-5
White S. W., 2011, SOCIAL ANXIETY DISOR, P183, DOI 10.1037/12315-010
White SW, 2009, J AUTISM DEV DISORD, V39, P1006, DOI 10.1007/s10803-009-0713-8
Williamson S, 2008, AUTISM, V12, P391, DOI 10.1177/1362361308091652
NR 61
TC 4
Z9 4
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1362-3613
J9 AUTISM
JI Autism
PD SEP
PY 2012
VL 16
IS 5
BP 453
EP 464
DI 10.1177/1362361311431951
PG 12
WC Psychology, Developmental
SC Psychology
GA 014CL
UT WOS:000309352600002
PM 22589452
ER
PT J
AU Sharma, S
Woolfson, LM
Hunter, SC
AF Sharma, Shilpi
Woolfson, Lisa Marks
Hunter, Simon C.
TI Confusion and inconsistency in diagnosis of Asperger syndrome: a review
of studies from 1981 to 2010
SO AUTISM
LA English
DT Review
DE Asperger syndrome; high functioning autism; autism; diagnostic
confusion; diagnostic debate; diagnostic status of Asperger Syndrome
ID HIGH-FUNCTIONING AUTISM; PERVASIVE DEVELOPMENTAL DISORDERS; SPECTRUM
DISORDER; PRESCHOOL-CHILDREN; LEARNING-DISABILITIES; PDD-NOS; MOTOR;
LANGUAGE; COMMUNICATION; INDIVIDUALS
AB This paper presents a review of past and current research on the diagnosis of Asperger syndrome (AS) in children. It is suggested that the widely used criteria for diagnosing AS in the Diagnostic and Statistical Manual of Mental Disorders (DSM)-IV are insufficient and invalid for a reliable diagnosis of AS. In addition, when these diagnostic criteria are applied, there is the potential bias of receiving a diagnosis towards the high-functioning end of the autism spectrum. Through a critical review of 69 research studies carried out between 1981 and 2010, this paper shows that six possible criteria for diagnosing AS (specifically, the age at which signs and symptoms related to autism become apparent, language and social communication abilities, intellectual abilities, motor or movement skills, repetitive patterns of behaviour and the nature of social interaction) overlap with the criteria for diagnosing autism. However, there is a possibility that some finer differences exist in the nature of social interaction, motor skills and speech patterns between groups with a diagnosis of AS and autism. These findings are proposed to be of relevance for designing intervention studies aimed at the treatment of specific symptoms in people with an autism spectrum disorder.
C1 [Sharma, Shilpi; Woolfson, Lisa Marks; Hunter, Simon C.] Univ Strathclyde, Sch Psychol Sci & Hlth, Glasgow, Lanark, Scotland.
RP Sharma, S (reprint author), Univ Strathclyde, Sch Psychol Sci & Hlth, Glasgow, Lanark, Scotland.
EM shilpi.cd2@gmail.com
RI Hunter, Simon/C-4221-2014
OI Hunter, Simon/0000-0002-3922-1252
CR American Psychiatric Association, 1987, DIAGN STAT MAN MENT
American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th
American Psychiatric Association, 1980, DIAGN STAT MAN MENT
Asperger H, 1944, ARCH PSYCHIAT NERVEN, V117, P76, DOI 10.1007/BF01837709
Barbaro J, 2007, J AUTISM DEV DISORD, V37, P1235, DOI 10.1007/s10803-006-0267-y
Beaumont R, 2006, AUTISM, V10, P365, DOI 10.1177/1362361306064416
Bennett T, 2008, J AUTISM DEV DISORD, V38, P616, DOI 10.1007/s10803-007-0428-7
Cederlund M, 2008, J AUTISM DEV DISORD, V38, P72, DOI 10.1007/s10803-007-0364-6
Chakrabarti S, 2001, JAMA-J AM MED ASSOC, V285, P3093, DOI 10.1001/jama.285.24.3093
Cox A, 1999, J CHILD PSYCHOL PSYC, V40, P719, DOI 10.1111/1469-7610.00488
Cuccaro ML, 2007, CHILD PSYCHIAT HUM D, V37, P347, DOI 10.1007/s10578-006-0052-y
Dahlgren S, 2008, AUTISM, V12, P335, DOI 10.1177/1362361308091648
de Bruin EI, 2007, J AUTISM DEV DISORD, V37, P877, DOI 10.1007/s10803-006-0215-x
Ehlers S, 1997, J CHILD PSYCHOL PSYC, V38, P207, DOI 10.1111/j.1469-7610.1997.tb01855.x
Eisenmajer R, 1996, J AM ACAD CHILD PSY, V35, P1523, DOI 10.1097/00004583-199611000-00022
Enticott PG, 2009, DEV MED CHILD NEUROL, V51, P787, DOI 10.1111/j.1469-8749.2009.03270.x
FINE J, 1991, J CHILD PSYCHOL PSYC, V32, P771, DOI 10.1111/j.1469-7610.1991.tb01901.x
Gadow KD, 2005, AUTISM, V9, P392, DOI 10.1177/1362361305056079
Gadow KD, 2004, J AUTISM DEV DISORD, V34, P379, DOI 10.1023/B:JADD.0000037415.21458.93
GHAZIUDDIN M, 1992, J AUTISM DEV DISORD, V22, P643, DOI 10.1007/BF01046332
Ghaziuddin M, 1996, J AUTISM DEV DISORD, V26, P585, DOI 10.1007/BF02172348
Ghaziuddin M, 1995, J INTELL DISABIL RES, V39, P538
Ghaziuddin M, 2004, J AUTISM DEV DISORD, V34, P279, DOI 10.1023/B:JADD.0000029550.19098.77
Ghaziuddin M, 2008, J AUTISM DEV DISORD, V38, P138, DOI 10.1007/s10803-007-0371-7
GHAZIUDDIN M, 1994, J INTELL DISABIL RES, V38, P519
Ghaziuddin M, 1998, J INTELL DISABIL RES, V42, P43, DOI 10.1046/j.1365-2788.1998.00065.x
Gilchrist A, 2001, J CHILD PSYCHOL PSYC, V42, P227, DOI 10.1017/S0021963001006631
Gillberg C., 2000, AUTISM, V4, P11, DOI 10.1177/1362361300004001002
GILLBERG IC, 1989, J CHILD PSYCHOL PSYC, V30, P631, DOI 10.1111/j.1469-7610.1989.tb00275.x
Hippler K, 2003, PHILOS T ROY SOC B, V358, P291, DOI 10.1098/rstb.2002.1197
Howlin P, 2003, J AUTISM DEV DISORD, V33, P3, DOI 10.1023/A:1022270118899
Humphrey N, 2008, AUTISM, V12, P23, DOI 10.1177/1362361307085267
Iwanaga R, 2000, J AUTISM DEV DISORD, V30, P169, DOI 10.1023/A:1005467807937
Jansiewicz EM, 2006, J AUTISM DEV DISORD, V36, P613, DOI 10.1007/s10803-006-0109-y
Joliffe T., 1999, J AUTISM DEV DISORD, V29, P395
Kadesjo B, 1999, J AUTISM DEV DISORD, V29, P327, DOI 10.1023/A:1022115520317
Kaland N, 2007, AUTISM, V11, P81, DOI 10.1177/1362361307070988
Kanner L, 1943, NERV CHILD, V2, P217
Kim JA, 2000, INT J RES PRACTICE, V4, P117
KLIN A, 1995, J CHILD PSYCHOL PSYC, V36, P1127, DOI 10.1111/j.1469-7610.1995.tb01361.x
Klin A, 2005, J AUTISM DEV DISORD, V35, P221, DOI 10.1007/s10803-005-2001-6
Kurita H, 1997, PSYCHIAT CLIN NEUROS, V51, P67, DOI 10.1111/j.1440-1819.1997.tb02909.x
Latif AHA, 2007, AUTISM, V11, P479, DOI 10.1177/1362361307083256
Lewis FM, 2007, RES AUTISM SPECT DIS, V1, P85, DOI 10.1016/j.rasd.2006.08.001
Manjiviona J., 1999, AUTISM, V3, P327, DOI DOI 10.1177/1362361399003004003
Matson JL, 2008, RES AUTISM SPECT DIS, V2, P288, DOI 10.1016/j.rasd.2007.07.003
Mayes SD, 2001, AUTISM, V5, P81, DOI 10.1177/1362361301005001008
Mayes SD, 2001, J ABNORM CHILD PSYCH, V29, P263, DOI 10.1023/A:1010337916636
McConachie H, 2005, J AUTISM DEV DISORD, V35, P167, DOI 10.1007/s10803-005-1995-0
Miller JN, 2000, J ABNORM PSYCHOL, V109, P227, DOI 10.1037/0021-843X.109.2.227
Miller JN, 1997, J CHILD PSYCHOL PSYC, V38, P247
Miyahara M, 1997, J AUTISM DEV DISORD, V27, P595, DOI 10.1023/A:1025834211548
Ozonoff S., 2000, AUTISM, V4, P29, DOI DOI 10.1177/1362361300041003
OZONOFF S, 1991, J CHILD PSYCHOL PSYC, V32, P1107, DOI 10.1111/j.1469-7610.1991.tb00352.x
Paul R, 2009, J AUTISM DEV DISORD, V39, P115, DOI 10.1007/s10803-008-0607-1
Pijnacker J, 2009, J AUTISM DEV DISORD, V39, P607, DOI 10.1007/s10803-008-0661-8
Pomeroy JC, 1998, ASPERGER SYNDROME HI
Rajendran G, 2005, J AUTISM DEV DISORD, V35, P429, DOI 10.1007/s10803-005-5033-z
Rinehart NJ, 2006, AUTISM, V10, P70, DOI 10.1177/1362361306062011
Rinehart NJ, 2001, AUTISM, V5, P67, DOI 10.1177/1362361301005001007
Rinehart NJ, 2006, J AUTISM DEV DISORD, V36, P757, DOI 10.1007/s10803-006-0118-x
Ritvo RA, 2008, COMPR PSYCHIAT, V49, P1, DOI 10.1016/j.comppsych.2007.06.010
Saulnier CA, 2007, J AUTISM DEV DISORD, V37, P788, DOI 10.1007/s10803-006-0288-6
Sayhoun C., 2009, J AUTISM DEV DISORD, V39, P1014
Sciutto MJ, 2005, J DEV PHYS DISABIL, V17, P345, DOI 10.1007/s10882-005-6618-3
Seung HK, 2007, CLIN LINGUIST PHONET, V21, P247, DOI 10.1080/02699200701195081
Smith MW, 2005, J AUTISM DEV DISORD, V35, P235
South M, 2005, J AUTISM DEV DISORD, V35, P145, DOI 10.1007/s10803-005-1992-3
Spek AA, 2008, J AUTISM DEV DISORD, V38, P782, DOI 10.1007/s10803-007-0446-5
Spencer JV, 2006, PERCEPTION, V35, P1047, DOI 10.1068/p5328
Starr E, 2003, J AUTISM DEV DISORD, V33, P15, DOI 10.1023/A:1022222202970
Szatmari P, 2009, J CHILD PSYCHOL PSYC, V50, P1459, DOI 10.1111/j.1469-7610.2009.02123.x
SZATMARI P, 1995, J AM ACAD CHILD PSY, V34, P1662, DOI 10.1097/00004583-199512000-00017
SZATMARI P, 1989, DEV MED CHILD NEUROL, V31, P709
Szatmari P, 2000, AM J PSYCHIAT, V157, P1980, DOI 10.1176/appi.ajp.157.12.1980
TANTAM D, 1988, J CHILD PSYCHOL PSYC, V29, P245, DOI 10.1111/j.1469-7610.1988.tb00713.x
Thede LL, 2007, J AUTISM DEV DISORD, V37, P847, DOI 10.1007/s10803-006-0212-0
Toal F, 2010, PSYCHOL MED, V40, P1171, DOI 10.1017/S0033291709991541
Tonge B. J., 1999, AUTISM, V3, P117, DOI DOI 10.1177/1362361399003002003
Tsermentseli S, 2008, J AUTISM DEV DISORD, V38, P1201, DOI 10.1007/s10803-007-0500-3
Verte S, 2006, J AUTISM DEV DISORD, V36, P351, DOI 10.1007/s10803-006-0074-5
Volkmar FR, 2009, J CHILD PSYCHOL PSYC, V50, P108, DOI 10.1111/j.1469-7610.2008.02010.x
Walker DR, 2004, J AM ACAD CHILD PSY, V43, P172, DOI 10.1097/01.chi.0000101375.03068.db
Weisbrot DM, 2005, J CHILD ADOL PSYCHOP, V15, P477, DOI 10.1089/cap.2005.15.477
WHO, 1993, ICD 10 CLASS MENT BE
WING L, 1981, PSYCHOL MED, V11, P115
Witwer AN, 2008, J AUTISM DEV DISORD, V38, P1611, DOI 10.1007/s10803-008-0541-2
Ziatas K, 1998, J CHILD PSYCHOL PSYC, V39, P755, DOI 10.1017/S0021963098002510
NR 88
TC 8
Z9 8
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1362-3613
J9 AUTISM
JI Autism
PD SEP
PY 2012
VL 16
IS 5
BP 465
EP 486
DI 10.1177/1362361311411935
PG 22
WC Psychology, Developmental
SC Psychology
GA 014CL
UT WOS:000309352600003
PM 21810909
ER
PT J
AU Maljaars, J
Noens, I
Scholte, E
van Berckelaer-Onnes, I
AF Maljaars, Jarymke
Noens, Ilse
Scholte, Evert
van Berckelaer-Onnes, Ina
TI Evaluation of the criterion and convergent validity of the Diagnostic
Interview for Social and Communication Disorders in young and
low-functioning children
SO AUTISM
LA English
DT Article
DE autism spectrum disorder; DISCO-11; diagnostic interview; validity
ID PERVASIVE DEVELOPMENTAL DISORDERS; OBSERVATION-SCHEDULE;
MENTAL-RETARDATION; SPECTRUM DISORDERS; REVISED ALGORITHMS; AUTISM;
QUESTIONNAIRE; ADOLESCENTS; POPULATION; CHECKLIST
AB The Diagnostic Interview for Social and Communication Disorders (DISCO; Wing, 2006) is a standardized, semi-structured and interviewer-based schedule for diagnosis of autism spectrum disorder (ASD). The objective of this study was to evaluate the criterion and convergent validity of the DISCO-11 ICD-10 algorithm in young and low-functioning children. The DISCO-11, Autism Diagnostic Observation Schedule (ADOS), and Social Communication Questionnaire (SCQ) were administered to a Dutch sample of 115 children comprising 52 children with ASD (both with and without intellectual disability), 26 children with intellectual disability (non-ASD), and 37 typically developing children. Results indicated high sensitivity and specificity for DISCO-11 classifications in differentiating ASD from non-ASD according to the clinical classification in children with mild intellectual disability or average intelligence. Among children with a moderate or severe intellectual disability the sensitivity was equally high, but the specificity was significantly lower. The agreement between DISCO-11 and ADOS classifications was substantial, between DISCO-11 and SCQ moderate. The correlations between raw scores of the DISCO and ADOS algorithm or SCQ were both high. In conclusion, the DISCO-11 differentiates accurately between autistic disorder and non-ASD in young children with an average intelligence or mild intellectual disability, but is over inclusive in the lower levels of intellectual disability.
C1 [Maljaars, Jarymke] Leiden Univ, Fac Social & Behav Sci, NL-2300 RB Leiden, Netherlands.
[Noens, Ilse] Katholieke Univ Leuven, Louvain, Belgium.
RP Maljaars, J (reprint author), Leiden Univ, Fac Social & Behav Sci, POB 9555, NL-2300 RB Leiden, Netherlands.
EM maljaars@fsw.leidenuniv.nl
CR American Psychiatric Association, 2010, DSM V DEV PROP REV
Berument SK, 1999, BRIT J PSYCHIAT, V175, P444, DOI 10.1192/bjp.175.5.444
Bhaumik S, 2010, RES DEV DISABIL, V31, P705, DOI 10.1016/j.ridd.2010.01.012
Bishop S.L., 2008, AUTISM SPECTRUM DISO, P23
Chandler S, 2007, J AM ACAD CHILD PSY, V46, P1324, DOI 10.1097/chi.0b013e31812f7d8d
Corsello C, 2007, J CHILD PSYCHOL PSYC, V48, P932, DOI 10.1111/j.1469-7610.2007.01762.x
de Bildt A, 2004, J AUTISM DEV DISORD, V34, P129
de Bildt A, 2003, J AUTISM DEV DISORD, V33, P595, DOI 10.1023/B:JADD.0000005997.92287.a3
Evers A., 2009, COMMISSIE TESTAANGEL
Filipek PA, 1999, J AUTISM DEV DISORD, V29, P439, DOI 10.1023/A:1021943802493
Gotham K, 2007, J AUTISM DEV DISORD, V37, P613, DOI 10.1007/s10803-006-0280-1
Gotham K, 2008, J AM ACAD CHILD PSY, V47, P642, DOI 10.1097/CHI.0b013e31816bffb7
Gray KM, 2008, J AUTISM DEV DISORD, V38, P657, DOI 10.1007/s10803-007-0432-y
Leekam SR, 2002, J CHILD PSYCHOL PSYC, V43, P327, DOI 10.1111/1469-7610.00024
Lord C., 1999, AUTISM DIAGNOSTIC OB
Lord C, 2010, SOCIAL POLICY REPORT, V24, P1
LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
Nygren G, 2009, J AUTISM DEV DISORD, V39, P730, DOI 10.1007/s10803-008-0678-z
Posserud M, 2010, SOC PSYCH PSYCH EPID, V45, P319, DOI 10.1007/s00127-009-0087-4
Rutter M., 2003, SCQ SOCIAL COMMUNICA
Schlichting J. E. P., 1995, SCHLICHTING TEST TAA
Snow AV, 2008, AUTISM, V12, P627, DOI 10.1177/1362361308097116
Tellegen P. J., 1998, SNIJDERS OOMEN NIET
van Berckelaer-Onnes I. A., 2008, DIAGNOSTIC INTERVIEW
Van Eldik M., 1995, REYNELL TEST TAALBEG
Vig S, 1999, J AUTISM DEV DISORD, V29, P235, DOI 10.1023/A:1023084106559
Warreyn P, 2004, SCQ VRAGENLIJST SOCI
Wiggins L. D., 2007, FOCUS AUTISM OTHER D, V22, P33, DOI [10.1177/10883576070220010401, DOI 10.1177/10883576070220010401]
Wing L, 2002, J CHILD PSYCHOL PSYC, V43, P307, DOI 10.1111/1469-7610.00023
Wing L, 2006, DIAGNOSTIC INTERVIEW
Witwer AN, 2007, J INTELLECT DEV DIS, V32, P179, DOI 10.1080/13668250701604776
NR 32
TC 4
Z9 4
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1362-3613
J9 AUTISM
JI Autism
PD SEP
PY 2012
VL 16
IS 5
BP 487
EP 497
DI 10.1177/1362361311402857
PG 11
WC Psychology, Developmental
SC Psychology
GA 014CL
UT WOS:000309352600004
PM 21690082
ER
PT J
AU Patterson, SY
Smith, V
Mirenda, P
AF Patterson, Stephanie Y.
Smith, Veronica
Mirenda, Pat
TI A systematic review of training programs for parents of children with
autism spectrum disorders: Single subject contributions
SO AUTISM
LA English
DT Review
DE autism; intervention; parent training; communication; single subject
research design
ID YOUNG-CHILDREN; SOCIAL-INTERACTION; EARLY INTERVENTION; PRESCHOOL;
SKILLS; TRIAL; COMMUNICATION; EDUCATION; PARADIGM; FAMILIES
AB Aim: The purpose of this systematic review was to examine research utilizing single subject research designs (SSRD) to explore the effectiveness of interventions designed to increase parents' ability to support communication and social development in children with autism spectrum disorders (ASDs).
Method: Included studies were systematically assessed for methodological quality (Logan et al., 2008; Smith et al., 2007) and intervention effects. Data examining participant characteristics, study methodology, outcomes, and analysis were systematically extracted.
Results: Eleven SSRD parent-training intervention studies examining 44 participants with ASD were included. Overall, the studies were of moderate quality and reported increases in parent skills and child language and communication outcomes.
Interpretation: The results supported by improvement rate difference (IRD) analysis indicated several interventions demonstrated positive effects for both parent and child outcomes. However, limited generalization and follow-up data suggested only one intervention demonstrated parents' accurate and ongoing intervention implementation beyond training.
C1 [Patterson, Stephanie Y.] Univ Calif Los Angeles, Grad Sch Educ & Informat Studies, Los Angeles, CA 90095 USA.
[Smith, Veronica] Univ Alberta, Edmonton, AB T6G 2M7, Canada.
[Mirenda, Pat] Univ British Columbia, Vancouver, BC V5Z 1M9, Canada.
RP Patterson, SY (reprint author), Univ Calif Los Angeles, Grad Sch Educ & Informat Studies, Moore Hall 2027,Box 951521, Los Angeles, CA 90095 USA.
EM sypatterson@ucla.edu
CR Crockett JL, 2007, RES DEV DISABIL, V28, P23, DOI 10.1016/j.ridd.2005.10.003
Diggle T, 2002, COCHRANE DB SYST REV, V2
Drew A, 2002, EUR CHILD ADOLES PSY, V11, P266, DOI 10.1007/s00787-002-0299-6
Girolametto L, 2006, J COMMUN DISORD, V40, P470
Goldstein H, 2002, J AUTISM DEV DISORD, V32, P373, DOI 10.1023/A:1020589821992
Higgins JPT, 2009, COCHRANE HDB SYSTEMA
Ingersoll B, 2007, RES DEV DISABIL, V28, P163, DOI 10.1016/j.ridd.2006.02.004
Justice LM, 2007, EVIDENCE BASED PRACT, V2, P1
Kaiser A. P., 2000, EARLY EDUC DEV, V11, P423, DOI 10.1207/s15566935eed1104_4
Kashinath S, 2006, J SPEECH LANG HEAR R, V49, P466, DOI 10.1044/1092-4388(2006/036)
Koegel L. K., 1996, POSITIVE BEHAV SUPPO
KOEGEL RL, 1987, J AUTISM DEV DISORD, V17, P187, DOI 10.1007/BF01495055
Koegel RL, 1996, J AUTISM DEV DISORD, V26, P347, DOI 10.1007/BF02172479
KOEGEL RL, 1978, J APPL BEHAV ANAL, V11, P95, DOI 10.1901/jaba.1978.11-95
Koegel RL, 1989, TEACH PIVOTAL UNPUB
Koegel RL, 2002, J POSIT BEHAV INTERV, V4, P88, DOI 10.1177/109830070200400204
Kohler FW, 2001, TOP EARLY CHILD SPEC, V21, P93, DOI 10.1177/027112140102100203
Lafasakis M, 2007, J APPL BEHAV ANAL, V40, P685, DOI 10.1901/jaba.2007.685-689
Lang R., 2009, EVIDENCE BASED COMMU, V3, P174, DOI 10.1080/17489530903338861
LASKI KE, 1988, J APPL BEHAV ANAL, V21, P391, DOI 10.1901/jaba.1988.21-391
Logan LR, 2008, DEV MED CHILD NEUROL, V50, P99, DOI 10.1111/j.1469-8749.2007.02005.x
Lord C, 2003, AUTISM DIAGNOSTIC OB
Luther Edith H, 2005, J Sch Nurs, V21, P40, DOI 10.1177/10598405050210010901
Mahoney G, 1999, TOP EARLY CHILD SPEC, V19, P131, DOI 10.1177/027112149901900301
Matson ML, 2009, RES AUTISM SPECT DIS, V3, P868, DOI 10.1016/j.rasd.2009.02.003
McAuley I, 2000, LANCET, V356, P1228
McConachie H, 2007, J EVAL CLIN PRACT, V13, P120, DOI 10.1111/j.1365-2753.2006.00674.x
McConachie H, 2005, J PEDIATR-US, V147, P335, DOI 10.1016/j.jpeds.2005.03.056
Meadan H, 2009, TOP EARLY CHILD SPEC, V29, P90, DOI 10.1177/0271121409337950
Moes D., 1995, TEACHING CHILDREN AU, P79
National Research Council, 2001, ED CHILDR AUT
Nunes D., 2007, INT J DISABIL DEV ED, V4, P177, DOI [10.1080/10349120701330495, DOI 10.1080/10349120701330495]
Ospina MB, 2008, PLOS ONE, V3, P1, DOI DOI 10.1371/JOURNAL.PONE.0003755
Parker RI, 2007, J SPEC EDUC, V40, P194, DOI 10.1177/00224669070400040101
Parker RI, 2009, EXCEPT CHILDREN, V75, P135
Plant KM, 2007, RES DEV DISABIL, V28, P362, DOI 10.1016/j.ridd.2006.02.009
Rocha ML, 2007, J EARLY INTERVENTION, V29, P154, DOI 10.1177/105381510702900207
Rogers SJ, 2010, EARLY START DENVER M
RUSSO DC, 1977, J APPL BEHAV ANAL, V10, P579, DOI 10.1901/jaba.1977.10-579
Sameroff A.J., 2009, TRANSACTIONAL MODEL
Scherer MR, 2005, J CONSULT CLIN PSYCH, V73, P525
Schopler E., 1988, CHILDHOOD AUTISM RAT
Siller M, 2002, J AUTISM DEV DISORD, V32, P77, DOI 10.1023/A:1014884404276
Smith T, 2007, J AUTISM DEV DISORD, V37, P354, DOI 10.1007/s10803-006-0173-3
Stahmer A. C., 2001, J POSIT BEHAV INTERV, V3, P75, DOI DOI 10.1177/109830070100300203
STRAIN PS, 1995, J EMOT BEHAV DISORD, V3, P2
Stutsman R., 1948, MERRILL PALMER SCALE
Symon JB, 2005, J POSIT BEHAV INTERV, V7, P159, DOI 10.1177/10983007050070030501
Vismara LA, 2009, AUTISM, V13, P93, DOI 10.1177/1362361307098516
Wetherby AM, 2006, SOCIAL COMMUNICATION
Whittingham K, 2006, RES DEV DISABIL, V27, P364, DOI 10.1016/j.ridd.2005.05.003
WILDMAN RW, 1978, J CLIN PSYCHOL, V34, P144, DOI 10.1002/1097-4679(197801)34:1<144::AID-JCLP2270340132>3.0.CO;2-U
Yoder P, 2004, MENT RETARD DEV D R, V10, P162, DOI 10.1002/mrdd.20013
NR 53
TC 8
Z9 9
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1362-3613
J9 AUTISM
JI Autism
PD SEP
PY 2012
VL 16
IS 5
BP 498
EP 522
DI 10.1177/1362361311413398
PG 25
WC Psychology, Developmental
SC Psychology
GA 014CL
UT WOS:000309352600005
PM 22250194
ER
PT J
AU Kissine, M
De Brabanter, P
Leybaert, J
AF Kissine, Mikhail
De Brabanter, Philippe
Leybaert, Jacqueline
TI Compliance with requests by children with autism: the impact of sentence
type
SO AUTISM
LA English
DT Article
DE indirect speech acts; naturalistic study; non-literal speech; pragmatics
ID ASPERGER-SYNDROME; MIND; COMPREHENSION; DECEPTION; LANGUAGE;
EXPLORATION; METAPHOR
AB This study assesses the extent to which children with autism understand requests performed with grammatically non-imperative sentence types. Ten children with autism were videotaped in naturalistic conditions. Four grammatical sentence types were distinguished: imperative, declarative, interrogative and sub-sentential. For each category, the proportion of requests complied with significantly exceeded the proportion of requests not complied with, and no difference across categories was found. These results show that children with autism do not rely exclusively on the linguistic form to interpret an utterance as a request.
C1 [Kissine, Mikhail] Univ Libre Brussels, FRS FNRS, B-1050 Brussels, Belgium.
RP Kissine, M (reprint author), Univ Libre Brussels, FRS FNRS, CP 175,Av FD Roosevelt, B-1050 Brussels, Belgium.
EM mkissine@ulb.ac.be
CR Capps L., 1998, AUTISM, V2, P325, DOI DOI 10.1177/1362361398024002
CARRELL PL, 1981, J CHILD LANG, V8, P329
Chevallier C, 2010, J AUTISM DEV DISORD, V40, P1104, DOI 10.1007/s10803-010-0960-8
CLARK HH, 1975, J VERB LEARN VERB BE, V14, P56, DOI 10.1016/S0022-5371(75)80006-5
de Villiers J., 2007, MIDWEST STUD PHILOS, V31, P292, DOI DOI 10.1111/J.1475-4975.2007.00151.X
Dennis M, 2001, J AUTISM DEV DISORD, V31, P47, DOI 10.1023/A:1005661613288
HAPPE FGE, 1993, COGNITION, V48, P101, DOI 10.1016/0010-0277(93)90026-R
Kaland N, 2002, J CHILD PSYCHOL PSYC, V43, P517, DOI 10.1111/1469-7610.00042
Khomsi A., 2001, EVALUATION LANGUAGE
LEEKAM SR, 1994, J CHILD PSYCHOL PSYC, V35, P901, DOI 10.1111/j.1469-7610.1994.tb02301.x
Macaulay M., PRAGMATICS IN PRESS
MacKay G, 2005, CHILD LANG TEACH THE, V20, P13
Martin I, 2004, J AUTISM DEV DISORD, V34, P311, DOI 10.1023/B:JADD.0000029553.52889.15
Norbury CF, 2005, BRIT J DEV PSYCHOL, V23, P383, DOI 10.1348/026151005X26732
Ozonoff S, 1996, BRAIN LANG, V52, P411, DOI 10.1006/brln.1996.0022
PAUL R, 1985, J SPEECH HEAR RES, V28, P475
Pijnacker J, 2009, J AUTISM DEV DISORD, V39, P607, DOI 10.1007/s10803-008-0661-8
REEDER K, 1980, J CHILD LANG, V7, P13
Rundblad G, 2010, AUTISM, V14, P29, DOI 10.1177/1362361309340667
SHATZ M, 1978, COGNITIVE PSYCHOL, V10, P271, DOI 10.1016/0010-0285(78)90001-4
SODIAN B, 1991, CHILD DEV, V62, P468, DOI 10.1111/j.1467-8624.1991.tb01545.x
Tager-Flusberg H., 2000, UNDERSTANDING OTHER, P124
Talwar V, 2007, DEV PSYCHOL, V43, P804, DOI 10.1037/0012-1649.43.3.804
The Language Archive of the Max Planck Institute for Psycholinguistics, 2012, ELAN
WINNER E, 1991, BRIT J DEV PSYCHOL, V9, P257
NR 25
TC 1
Z9 1
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1362-3613
J9 AUTISM
JI Autism
PD SEP
PY 2012
VL 16
IS 5
BP 523
EP 531
DI 10.1177/1362361311406296
PG 9
WC Psychology, Developmental
SC Psychology
GA 014CL
UT WOS:000309352600006
PM 22399448
ER
PT J
AU Griffith, GM
Totsika, V
Nash, S
Hastings, RP
AF Griffith, Gemma M.
Totsika, Vasiliki
Nash, Susie
Hastings, Richard P.
TI 'I just don't fit anywhere': support experiences and future support
needs of individuals with Asperger syndrome in middle adulthood
SO AUTISM
LA English
DT Article
DE Asperger syndrome; support services; qualitative; adults
ID INTERPRETATIVE PHENOMENOLOGICAL ANALYSIS; AUTISM; PERCEPTIONS;
PSYCHOLOGY; DIAGNOSIS; MOTHERS; SCHOOL
AB The experiences of individuals in middle adulthood with Asperger syndrome have been the subject of little previous research, especially in terms of their experience of support services. In the present research, 11 adults with Asperger syndrome were interviewed. Interpretative phenomenological analysis (IPA) was used to interpret the interviews. Four themes emerged from the analysis: living with Asperger syndrome; employment issues; experiences with mainstream support; and future steps towards supporting adults with Asperger syndrome. The findings highlighted the anxiety, depression, and communication difficulties that people with Asperger syndrome may experience. Much of the available support is perceived as unsuitable for individuals with Asperger syndrome. All participants wanted to remain as independent as possible, and believed an individualized approach to support would be greatly beneficial. Recommendations are made for future practice to help support adults with Asperger syndrome.
C1 [Griffith, Gemma M.; Totsika, Vasiliki; Nash, Susie; Hastings, Richard P.] Bangor Univ, Sch Psychol, Bangor II57 2AS, Gwynedd, Wales.
RP Griffith, GM (reprint author), Bangor Univ, Sch Psychol, Brigantia Bldg,Penrhalt Rd, Bangor II57 2AS, Gwynedd, Wales.
EM griffith@bangor.ac.uk
RI Hastings, Richard/D-9657-2013
OI Hastings, Richard/0000-0002-0495-8270
CR American Psychiatric Association (APA), 1994, DIAGN STAT MAN MENT, V4th
Baron-Cohen S, 2004, J AUTISM DEV DISORD, V34, P163, DOI 10.1023/B:JADD.0000022607.19833.00
Brocki JM, 2006, PSYCHOL HEALTH, V21, P87, DOI 10.1080/14768320500230185
Carrington S, 2001, AUTISM, V5, P37, DOI 10.1177/1362361301005001004
Department of Health, 2010, FULF REW LIV STRAT A
Elliott R, 1999, BRIT J CLIN PSYCHOL, V38, P215, DOI 10.1348/014466599162782
Harker M, 2004, TOMORROWS BIG PROBLE
Hendricks DR, 2009, FOCUS AUTISM DEV DIS, V24, P77, DOI 10.1177/1088357608329827
Howard B, 2006, AUTISM, V33, P489
Howlin P, 2004, J CHILD PSYCHOL PSYC, V45, P212, DOI 10.1111/j.1469-7610.2004.00215.x
Hurlbutt K., 2002, FOCUS AUTISM OTHER D, V17, P103, DOI [10.1177/10883576020170020501, DOI 10.1177/10883576020170020501]
Hurlbutt K, 2004, FOCUS AUTISM OTHER D, V19, P215, DOI DOI 10.1177/10883576040190040301
Huws JC, 2008, J INTELLECT DEV DIS, V33, P99, DOI 10.1080/13668250802010394
Molloy H., 2004, ASPERGER SYNDROME AD
Muller E, 2003, J VOCATIONAL REHABIL, V18, P163
Muller E, 2008, AUTISM, V12, P173, DOI 10.1177/1362361307086664
Powell A., 2002, TAKING RESPONSIBILIT
Punshon C, 2009, AUTISM, V13, P265, DOI 10.1177/1362361309103795
Reilly DE, 2008, J APPL RES INTELLECT, V21, P546, DOI 10.1111/j.1468-3148.2008.00427.x
Smith J. A., 1999, QUALITATIVE HLTH PSY, P218
Smith JA, 2002, J HEALTH PSYCHOL, V7, P131, DOI 10.1177/1359105302007002398
Sturges JE, 2004, QUALITATIVE RES, V4, P107, DOI DOI 10.1177/1468794104041110
Williams E, 2004, THEOR PSYCHOL, V14, P704, DOI 10.1177/0959354304046180
Willig C, 2001, INTRO QUALITATIVE RE
NR 24
TC 8
Z9 8
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1362-3613
J9 AUTISM
JI Autism
PD SEP
PY 2012
VL 16
IS 5
BP 532
EP 546
DI 10.1177/1362361311405223
PG 15
WC Psychology, Developmental
SC Psychology
GA 014CL
UT WOS:000309352600007
PM 21610188
ER
PT J
AU Poulopoulos, A
Soykan, T
Tuffy, LP
Hammer, M
Varoqueaux, F
Brose, N
AF Poulopoulos, Alexandros
Soykan, Tolga
Tuffy, Liam P.
Hammer, Matthieu
Varoqueaux, Frederique
Brose, Nils
TI Homodimerization and isoform-specific heterodimerization of neuroligins
SO BIOCHEMICAL JOURNAL
LA English
DT Article
DE autism; cross-linking; dimer; endoplasmic reticulum (ER) retention;
oligomerization; synaptic adhesion; transmembrane domain
ID ENDOPLASMIC-RETICULUM RETENTION; FOLD PROTEIN FAMILY; INHIBITORY
SYNAPSES; TRANSMEMBRANE HELIX; NEUREXIN COMPLEX; GAMMA-SECRETASE; AUTISM
REVEALS; BETA-NEUREXINS; DENTATE GYRUS; CELL-ADHESION
AB Neuroligins are postsynaptic adhesion proteins involved in the establishment of functional synapses in the central nervous system. In rodents, four genes give rise to neuroligins that function at distinct synapses, with corresponding neurotransmitter and subtype specificities. In the present study, we examined the interactions between the different neuroligins by isolating endogenous oligomeric complexes using in situ cross-linking on primary neurons. Examining hippocampal, striatal, cerebellar and spinal cord cultures, we found that neuroligins form constitutive dimers, including homomers and, most notably, neuroligin 1/3 heteromers. Additionally, we found that neuroligin monomers are specifically retained in the secretory pathway through a cellular quality control mechanism that involves the neuroligin transmembrane domain, ensuring that dimerization occurs prior to cell surface trafficking. Lastly, we identified differences in the dimerization capacity of autism-associated neuroligin mutants, and found that neuroligin 3 R471C mutants can form heterodimers with neuroligin 1. The pervasive nature of neuroligin dimerization indicates that the unit of neuroligin function is the dimer, and raises intriguing possibilities of distinct heterodimer functions, and of interactions between native and mutant neuroligins contributing to disease phenotypes.
C1 [Varoqueaux, Frederique] Max Planck Inst Expt Med, Dept Mol Neurobiol, D-37075 Gottingen, Germany.
DFG Ctr Mol Physiol Brain, D-37075 Gottingen, Germany.
RP Varoqueaux, F (reprint author), Max Planck Inst Expt Med, Dept Mol Neurobiol, D-37075 Gottingen, Germany.
EM varoqueaux@em.mpg.de; brose@em.mpg.de
RI Poulopoulos, Alexandros/C-3659-2008
OI Poulopoulos, Alexandros/0000-0002-5318-7388
FU Max Planck Society; German Research Foundation [GRK 521, FZT 103];
European Commission (EUROSPIN); European Commission (SynSys); European
Commission (EU-AIMS); Cure Autism Now Foundation; Marie Curie IEF
fellowship [274972]
FX This work was supported by the Max Planck Society, the German Research
Foundation (grant numbers GRK 521 and FZT 103 (to F.V. and N.B.)], the
European Commission (EUROSPIN, SynSys, EU-AIMS; to N.B.) and the Cure
Autism Now Foundation (to F.V.). L.P.T. is a recipient of a Marie Curie
IEF fellowship [grant number 274972].
CR Arac D, 2007, NEURON, V56, P992, DOI 10.1016/j.neuron.2007.12.002
BREWER GJ, 1995, J NEUROSCI RES, V42, P674, DOI 10.1002/jnr.490420510
Budreck EC, 2007, EUR J NEUROSCI, V26, P1738, DOI 10.1111/j.1460-9568.2007.05842.x
Choma C, 2000, NAT STRUCT BIOL, V7, P161
Chubykin AA, 2007, NEURON, V54, P919, DOI 10.1016/j.neuron.2007.05.029
Comoletti D, 2006, BIOCHEMISTRY-US, V45, P12816, DOI 10.1021/bi0614131
Comoletti D, 2008, CHEM-BIOL INTERACT, V175, P150, DOI 10.1016/j.cbi.2008.04.040
Comoletti D, 2004, J NEUROSCI, V24, P4889, DOI 10.1523/JNEUROSCI.0468-04.2004
Conroy WG, 2007, DEV BIOL, V307, P79, DOI 10.1016/j.ydbio.2007.04.017
Dean C, 2003, NAT NEUROSCI, V6, P708, DOI 10.1038/nn1074
De Jaco A, 2006, J BIOL CHEM, V281, P9667, DOI 10.1074/jbc.M510262200
De Jaco A, 2010, J BIOL CHEM, V285, P28674, DOI 10.1074/jbc.M110.139519
Ellgaard L, 2003, NAT REV MOL CELL BIO, V4, P181, DOI 10.1038/nrm1052
Fabrichny IP, 2007, NEURON, V56, P979, DOI 10.1016/j.neuron.2007.11.013
Graf ER, 2004, CELL, V119, P1013, DOI 10.1016/j.cell.2004.11.035
Hoon M, 2011, P NATL ACAD SCI USA, V108, P3053, DOI 10.1073/pnas.1006946108
ICHTCHENKO K, 1995, CELL, V81, P435, DOI 10.1016/0092-8674(95)90396-8
Ichtchenko K, 1996, J BIOL CHEM, V271, P2676
Irie M, 1997, SCIENCE, V277, P1511, DOI 10.1126/science.277.5331.1511
Jacob TC, 2008, NAT REV NEUROSCI, V9, P331, DOI 10.1038/nrn2370
Jamain S, 2008, P NATL ACAD SCI USA, V105, P1710, DOI 10.1073/pnas.0711555105
Jamain S, 2003, NAT GENET, V34, P27, DOI 10.1038/ng1136
Jedlicka P, 2011, CEREB CORTEX, V21, P357, DOI 10.1093/cercor/bhq100
Kaether C, 2007, EMBO REP, V8, P743, DOI 10.1038/sj.embor.7401027
Kaether C, 2006, NEURODEGENER DIS, V3, P275, DOI 10.1159/000095267
Koehnke J, 2008, P NATL ACAD SCI USA, V105, P1873, DOI 10.1073/pnas.0711701105
Levinson JN, 2007, NEURON, V56, P937, DOI 10.1016/j.neuron.2007.12.003
Levinson JN, 2005, J BIOL CHEM, V280, P17312, DOI 10.1074/jbc.M413812200
Li X, 2007, J NEUROCHEM, V102, P1329, DOI 10.1111/j.1471-4159.2007.04635.x
Lida J, 2004, MOL CELL NEUROSCI, V27, P497, DOI 10.1016/j.mcn.2004.08.006
Poulopoulos A, 2009, NEURON, V63, P628, DOI 10.1016/j.neuron.2009.08.023
Sato K, 2003, MOL BIOL CELL, V14, P3605, DOI 10.1091/mbc.E02-12-0777
Scheiffele P, 2000, CELL, V101, P657, DOI 10.1016/S0092-8674(00)80877-6
Song JY, 1999, P NATL ACAD SCI USA, V96, P1100, DOI 10.1073/pnas.96.3.1100
Stockner T, 2004, BIOPHYS J, V87, P1650, DOI 10.1529/biophysj.104.045310
Tabuchi K, 2007, SCIENCE, V318, P71, DOI 10.1126/science.1146221
Varoqueaux F, 2006, NEURON, V51, P741, DOI 10.1016/j.neuron.2006.09.003
Varoqueaux F, 2004, EUR J CELL BIOL, V83, P449, DOI 10.1078/0171-9335-00410
Zhang C, 2009, J NEUROSCI, V29, P10843, DOI 10.1523/JNEUROSCI.1248-09.2009
NR 39
TC 12
Z9 12
PU PORTLAND PRESS LTD
PI LONDON
PA THIRD FLOOR, EAGLE HOUSE, 16 PROCTER STREET, LONDON WC1V 6 NX, ENGLAND
SN 0264-6021
J9 BIOCHEM J
JI Biochem. J.
PD SEP 1
PY 2012
VL 446
BP 321
EP 330
DI 10.1042/BJ20120808
PN 2
PG 10
WC Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA 005RM
UT WOS:000308767500016
PM 22671294
ER
PT J
AU Jung, KM
Sepers, M
Henstridge, CM
Lassalle, O
Neuhofer, D
Martin, H
Ginger, M
Frick, A
DiPatrizio, NV
Mackie, K
Katona, I
Piomelli, D
Manzoni, OJ
AF Jung, Kwang-Mook
Sepers, Marja
Henstridge, Christopher M.
Lassalle, Olivier
Neuhofer, Daniela
Martin, Henry
Ginger, Melanie
Frick, Andreas
DiPatrizio, Nicholas V.
Mackie, Ken
Katona, Istvan
Piomelli, Daniele
Manzoni, Olivier J.
TI Uncoupling of the endocannabinoid signalling complex in a mouse model of
fragile X syndrome
SO NATURE COMMUNICATIONS
LA English
DT Article
ID METABOTROPIC GLUTAMATE RECEPTORS; DIACYLGLYCEROL-LIPASE-ALPHA;
MENTAL-RETARDATION PROTEIN; LONG-TERM DEPRESSION; NUCLEUS-ACCUMBENS;
SYNAPTIC PLASTICITY; MONOGLYCERIDE LIPASE; MESSENGER-RNAS; CB1 RECEPTOR;
TRANSLATION
AB Fragile X syndrome, the most commonly known genetic cause of autism, is due to loss of the fragile X mental retardation protein, which regulates signal transduction at metabotropic glutamate receptor-5 in the brain. Fragile X mental retardation protein deletion in mice enhances metabotropic glutamate receptor-5-dependent long-term depression in the hippocampus and cerebellum. Here we show that a distinct type of metabotropic glutamate receptor-5-dependent long-term depression at excitatory synapses of the ventral striatum and prefrontal cortex, which is mediated by the endocannabinoid 2-arachidonoyl-sn-glycerol, is absent in fragile X mental retardation protein-null mice. In these mutants, the macromolecular complex that links metabotropic glutamate receptor-5 to the 2-arachidonoyl-sn-glycerol-producing enzyme, diacylglycerol lipase-alpha (endocannabinoid signalosome), is disrupted and metabotropic glutamate receptor-5-dependent 2-arachidonoyl-sn-glycerol formation is compromised. These changes are accompanied by impaired endocannabinoid-dependent long-term depression. Pharmacological enhancement of 2-arachidonoyl-sn-glycerol signalling normalizes this synaptic defect and corrects behavioural abnormalities in fragile X mental retardation protein-deficient mice. The results identify the endocannabinoid signalosome as a molecular substrate for fragile X syndrome, which might be targeted by therapy.
C1 [Henstridge, Christopher M.; Katona, Istvan] Hungarian Acad Sci, Inst Expt Med, H-1083 Budapest, Hungary.
[Jung, Kwang-Mook; DiPatrizio, Nicholas V.; Piomelli, Daniele] Univ Calif Irvine, Dept Anat & Neurobiol, Irvine, CA 92697 USA.
[Sepers, Marja; Ginger, Melanie; Frick, Andreas; Manzoni, Olivier J.] INSERM, Circuit & Dendrit Mech Underlying Cort Plast Grp, Neuroctr Magendie, U862, F-33077 Bordeaux, France.
[Sepers, Marja; Ginger, Melanie; Frick, Andreas; Manzoni, Olivier J.] Univ Bordeaux, F-33077 Bordeaux, France.
[Lassalle, Olivier; Neuhofer, Daniela; Martin, Henry; Manzoni, Olivier J.] INSERM, U901, F-13009 Marseille, France.
[Lassalle, Olivier; Neuhofer, Daniela; Martin, Henry; Manzoni, Olivier J.] Univ Aix Marseille 2, UMR S901, Aix Marseille 2, France.
[Lassalle, Olivier; Neuhofer, Daniela; Martin, Henry; Manzoni, Olivier J.] INMED, F-13009 Marseille, France.
[Mackie, Ken] Indiana Univ, Dept Psychol & Brain Sci, Gill Ctr Biomol Sci, Bloomington, IN 47405 USA.
[Piomelli, Daniele] Univ Calif Irvine, Dept Biol Chem, Irvine, CA 92697 USA.
[Piomelli, Daniele] Italian Inst Technol, Unit Drug Discovery & Dev, I-16163 Genoa, Italy.
RP Katona, I (reprint author), Hungarian Acad Sci, Inst Expt Med, H-1083 Budapest, Hungary.
EM katona@koki.hu; piomelli@uci.edu; olivier.manzoni@inserm.fr
RI Katona, Istvan/D-9729-2011; Mackie, Ken/E-3715-2013
OI Katona, Istvan/0000-0003-2808-3330; Mackie, Ken/0000-0001-8501-6199
FU INSERM; ANR-Blanc France-Taiwan RescueMemo; FRAXA research foundation;
Brain and Behavior Research Foundation; National Institute on Drug Abuse
[DA-012447]; Hungarian Scientific Research Fund-Norwegian Financial
Mechanism Joint Program [NNF 78918]; European Research Council Grant
[243153]; NIH [DA-011322, DA-021696]; European Molecular Biology
Organization long-term fellowship
FX This work was supported by INSERM, ANR-Blanc France-Taiwan RescueMemo
(O.J.M), FRAXA research foundation (M.S. and O.J.M.), a NARSAD 2010
Independent Investigator Grant given by the Brain and Behavior Research
Foundation (O.J.M.), National Institute on Drug Abuse (DA-012447, D.P.),
the Hungarian Scientific Research Fund-Norwegian Financial Mechanism
Joint Program (NNF 78918), European Research Council Grant 243153 to
I.K. and NIH grants (DA-011322 and DA-021696) to K.M.C.M.H. was a
recipient of a European Molecular Biology Organization long-term
fellowship. The contribution of the Agilent Technologies/University of
California, Irvine Analytical Discovery Facility, Center for Drug
Discovery is gratefully acknowledged. We acknowledge FRAXA research
foundation (Dr D. Nelson, Baylor College of Medicine) for providing the
Fmr1 KO2 mice. We thank Mr L. Barna, the Nikon Microscopy Center at IEM,
Nikon Austria GmbH and Auro-Science Consulting Ltd for providing
microscopy support and B. Dudok for his help in electron microscopy. We
are grateful to Prof. Z. Nusser and Dr G. Nyiri for their help with
statistical analysis. The technical assistance of Dr E. Horvath, G.
Goda, B. Pinter, D. Thongkham and J. Lockney is also acknowledged.
O.J.M. is grateful to Dr P. Chavis and Po-Wu Gean for helpful
discussions and to R. Martinez for his help during the installation of
the new laboratory.
CR Astarita G, 2009, J CHROMATOGR B, V877, P2755, DOI 10.1016/j.jchromb.2009.01.008
Bagni C, 2005, NAT REV NEUROSCI, V6, P376, DOI 10.1038/nrn1667
Bear MF, 2008, NEUROPSYCHOPHARMACOL, V33, P84, DOI 10.1038/sj.npp.1301610
Brown V, 2001, CELL, V107, P477, DOI 10.1016/S0092-8674(01)00568-2
Chanda PK, 2010, MOL PHARMACOL, V78, P996, DOI 10.1124/mol.110.068304
Chevaleyre V, 2003, NEURON, V38, P461, DOI 10.1016/S0896-6273(03)00235-6
Darnell JC, 2011, CELL, V146, P247, DOI 10.1016/j.cell.2011.06.013
Dinh TP, 2002, CHEM PHYS LIPIDS, V121, P149, DOI 10.1016/S0009-3084(02)00150-0
Dinh TP, 2002, P NATL ACAD SCI USA, V99, P10819, DOI 10.1073/pnas.152334899
Dolen G, 2007, NEURON, V56, P955, DOI 10.1016/j.neuron.2007.12.001
Evans MS, 1998, J NEUROSCI METH, V79, P37, DOI 10.1016/S0165-0270(97)00159-3
Heifets BD, 2009, ANNU REV PHYSIOL, V71, P283, DOI 10.1146/annurev.physiol.010908.163149
Huber KM, 2002, P NATL ACAD SCI USA, V99, P7746, DOI 10.1073/pnas.122205699
Irwin SA, 2000, CEREB CORTEX, V10, P1038, DOI 10.1093/cercor/10.10.1038
Jarbe TUC, 2002, PHARMACOL BIOCHEM BE, V73, P911, DOI 10.1016/S0091-3057(02)00938-3
Jung KM, 2007, MOL PHARMACOL, V72, P612, DOI 10.1124/mol.107.037796
Jung KM, 2005, MOL PHARMACOL, V68, P1196, DOI 10.1124/mol.105.013961
Kao DI, 2010, P NATL ACAD SCI USA, V107, P15601, DOI 10.1073/pnas.1010564107
Kasanetz F, 2009, J NEUROPHYSIOL, V101, P2516, DOI 10.1152/jn.91039.2008
Katona I, 2008, NAT MED, V14, P923, DOI 10.1038/nm.f.1869
Katona I, 2006, J NEUROSCI, V26, P5628, DOI 10.1523/JNEUROSCI.0309-06.2006
Kelleher RJ, 2008, CELL, V135, P401, DOI 10.1016/j.cell.2008.10.017
King AR, 2009, CHEM BIOL, V16, P1045, DOI 10.1016/j.chembiol.2009.09.012
Krueger DD, 2011, ANNU REV MED, V62, P411, DOI 10.1146/annurev-med-061109-134644
Lafourcade M, 2011, NAT NEUROSCI, V14, P345, DOI 10.1038/nn.2736
Lafourcade M, 2007, PLOS ONE, V2, DOI 10.1371/journal.pone.0000709
LISTER RG, 1987, PSYCHOPHARMACOLOGY, V92, P180
Long JZ, 2009, NAT CHEM BIOL, V5, P37, DOI 10.1038/nchembio.129
Lujan R, 1996, EUR J NEUROSCI, V8, P1488, DOI 10.1111/j.1460-9568.1996.tb01611.x
Lujan R, 1997, J CHEM NEUROANAT, V13, P219, DOI 10.1016/S0891-0618(97)00051-3
Maccarrone M, 2010, NEUROPSYCHOPHARMACOL, V35, P1500, DOI 10.1038/npp.2010.19
Marrs WR, 2010, NAT NEUROSCI, V13, P951, DOI 10.1038/nn.2601
Mato S, 2008, NEUROPHARMACOLOGY, V54, P87, DOI 10.1016/j.neuropharm.2007.04.014
Penagarikano O, 2007, ANNU REV GENOM HUM G, V8, P109, DOI 10.1146/annurev.genom.8.080706.092249
Pilpel Y, 2009, J PHYSIOL-LONDON, V587, P787, DOI 10.1113/jphysiol.2008.160929
Piomelli D, 2003, NAT REV NEUROSCI, V4, P873, DOI 10.1038/nrn1247
PRESCOTT SM, 1981, J BIOL CHEM, V256, P579
Raiteri L, 2000, NEUROCHEM RES, V25, P1265, DOI 10.1023/A:1007648229795
Robbe D, 2002, P NATL ACAD SCI USA, V99, P8384, DOI 10.1073/pnas.122149199
Robbe D, 2002, J NEUROSCI, V22, P4346
Roloff AM, 2010, J NEUROSCI, V30, P3072, DOI 10.1523/JNEUROSCI.4603-09.2010
Ronesi JA, 2008, J NEUROSCI, V28, P543, DOI 10.1523/JNEUROSCI.5019-07.2008
Ronesi JA, 2008, SCI SIGNAL, V1, DOI 10.1126/stke.15pe6
Ronesi JA, 2012, NAT NEUROSCI, V15, P431, DOI 10.1038/nn.3033
Schlosburg JE, 2010, NAT NEUROSCI, V13, P1113, DOI 10.1038/nn.2616
Suvrathan A., 2011, P NATL ACAD SCI USA, V107, P11591
Tanimura A, 2010, NEURON, V65, P320, DOI 10.1016/j.neuron.2010.01.021
Todd PK, 2003, P NATL ACAD SCI USA, V100, P14374, DOI 10.1073/pnas.2336265100
VERKERK AJMH, 1991, CELL, V65, P905, DOI 10.1016/0092-8674(91)90397-H
Villasana LE, 2006, J NEUROSCI METH, V158, P30, DOI 10.1016/j.jneumeth.2006.05.008
Westmark CJ, 2007, PLOS BIOL, V5, P629, DOI 10.1371/journal.pbio.0050052
Won YJ, 2009, J NEUROSCI, V29, P13603, DOI 10.1523/JNEUROSCI.2244-09.2009
Yoshida T, 2006, J NEUROSCI, V26, P4740, DOI 10.1523/JNEUROSCI.0054-06.2006
Yuskaitis CJ, 2010, BIOCHEM PHARMACOL, V79, P632, DOI 10.1016/j.bcp.2009.09.023
Zhang LH, 2010, J NEUROSCI, V30, P5724, DOI 10.1523/JNEUROSCI.0795-10.2010
NR 55
TC 36
Z9 36
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 2041-1723
J9 NAT COMMUN
JI Nat. Commun.
PD SEP
PY 2012
VL 3
AR 1080
DI 10.1038/ncomms2045
PG 11
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 013XA
UT WOS:000309338100047
PM 23011134
ER
PT J
AU Taylor, JL
McPheeters, ML
Sathe, NA
Dove, D
Veenstra-VanderWeele, J
Warren, Z
AF Taylor, Julie Lounds
McPheeters, Melissa L.
Sathe, Nila A.
Dove, Dwayne
Veenstra-VanderWeele, Jeremy
Warren, Zachary
TI A Systematic Review of Vocational Interventions for Young Adults With
Autism Spectrum Disorders
SO PEDIATRICS
LA English
DT Review
DE autism spectrum disorders; supported employment; vocational training
ID FOLLOW-UP; EMPLOYMENT; COSTS; ADOLESCENTS; POPULATION; TRANSITION;
SERVICES; CHILDREN
AB BACKGROUND AND OBJECTIVE: Many individuals with autism spectrum disorders (ASDs) are approaching adolescence and young adulthood; interventions to assist these individuals with vocational skills are not well understood. This study systematically reviewed evidence regarding vocational interventions for individuals with ASD between the ages of 13 and 30 years.
METHODS: The Medline, PsycINFO, and ERIC databases (1980-December 2011) and reference lists of included articles were searched. Two reviewers independently assessed each study against predetermined inclusion/exclusion criteria. Two reviewers independently extracted data regarding participant and intervention characteristics, assessment techniques, and outcomes, and assigned overall quality and strength of evidence ratings based on predetermined criteria.
RESULTS: Five studies were identified; all were of poor quality and all focused on on-the-job supports as the employment/vocational intervention. Short-term studies reported that supported employment was associated with improvements in quality of life (1 study), ASD symptoms (1 study), and cognitive functioning (1 study). Three studies reported that interventions increased rates of employment for young adults with ASD.
CONCLUSIONS: Few studies have been conducted to assess vocational interventions for adolescents and young adults with ASD. As such, there is very little evidence available for specific vocational treatment approaches as individuals transition to adulthood. All studies of vocational approaches were of poor quality, which may reflect the recent emergence of this area of research. Individual studies suggest that vocational programs may increase employment success for some; however, our ability to understand the overall benefit of supported employment programs is limited given the existing research. Pediatrics 2012;130:531-538
C1 [Taylor, Julie Lounds; Dove, Dwayne; Warren, Zachary] Vanderbilt Kennedy Ctr, Dept Pediat, Nashville, TN 37203 USA.
[McPheeters, Melissa L.] Vanderbilt Univ Sch Med, Dept Obstet & Gynecol, Nashville, TN USA.
[McPheeters, Melissa L.; Sathe, Nila A.] Vanderbilt Univ Sch Med, Vanderbilt Evidence Based Practice Ctr, Inst Med & Publ Hlth, Nashville, TN USA.
[Veenstra-VanderWeele, Jeremy] Vanderbilt Kennedy Ctr, Treatment & Res Inst Autism Spectrum Disorders, Ctr Mol Neurosci, Dept Psychiat, Nashville, TN 37203 USA.
[Veenstra-VanderWeele, Jeremy] Vanderbilt Kennedy Ctr, Treatment & Res Inst Autism Spectrum Disorders, Ctr Mol Neurosci, Dept Pediat, Nashville, TN 37203 USA.
[Veenstra-VanderWeele, Jeremy] Vanderbilt Kennedy Ctr, Treatment & Res Inst Autism Spectrum Disorders, Ctr Mol Neurosci, Dept Pharmacol, Nashville, TN 37203 USA.
[Warren, Zachary] Vanderbilt Univ, Vanderbilt Kennedy Ctr, Treatment & Res Inst Autism Spectrum Disorders, Dept Pediat, Nashville, TN USA.
[Warren, Zachary] Vanderbilt Univ, Vanderbilt Kennedy Ctr, Treatment & Res Inst Autism Spectrum Disorders, Dept Psychiat, Nashville, TN USA.
RP Taylor, JL (reprint author), Vanderbilt Kennedy Ctr, Dept Pediat, PMB 40-230 Appleton Pl, Nashville, TN 37203 USA.
EM julie.l.taylor@vanderbilt.edu
FU Agency for Healthcare Research and Quality, US Department of Health and
Human Services [HHSA 290 2007 10065 I]; National Institute of Mental
Health [K01 MH092598]; Eunice Kennedy Shriver National Institute of
Child Health and Human Development; Autism Speaks; Marino Autism
Research Institute; National Institute of Child Health and Human
Development; Agency for Healthcare Research and Quality [HHSA 290 2007
10065 I]; American Academy of Child and Adolescent Psychiatry; NARSAD;
Seaside Therapeutics; Roche Pharmaceuticals; Novartis; National Science
Foundation; Simons Foundation
FX This project was funded under contract HHSA 290 2007 10065 I from the
Agency for Healthcare Research and Quality, US Department of Health and
Human Services. The authors of this report are responsible for its
content. Statements in the report should not be construed as endorsement
by the Agency for Healthcare Research and Quality or the US Department
of Health and Human Services.Dr Taylor has received research support
from the National Institute of Mental Health, the Eunice Kennedy Shriver
National Institute of Child Health and Human Development, Autism Speaks,
and the Marino Autism Research Institute. Dr Dove has received training
support from the National Institute of General Medical Sciences,
National Heart, Lung, and Blood Institute, National Institute of Child
Health and Human Development, Maternal Child Health Bureau, the American
Heart Association, and the Autism Speaks Autism Treatment Network. Dr
Veenstra-VanderWeele has received research support from the National
Institute of Mental Health, the National Institute of Child Health and
Human Development, the Agency for Healthcare Research and Quality,
Autism Speaks, the American Academy of Child and Adolescent Psychiatry,
NARSAD, Seaside Therapeutics, Roche Pharmaceuticals, and Novartis. He
has consulted for Novartis. Dr Warren has received research support from
the National Institute of Mental Health, the Eunice Kennedy Shriver
National Institute of Child Health and Human Development, the National
Science Foundation, the Agency for Healthcare Research and Quality,
Autism Speaks, the Marino Autism Research Institute, and the Simons
Foundation. Dr McPheeters and Ms Sathe have indicated they have no
financial relationships relevant to this article to disclose.The full
review project was supported by the Agency for Healthcare Research and
Quality (contract HHSA 290 2007 10065 I). The primary author was
supported by the National Institute of Mental Health through a K01 award
(K01 MH092598) during participation on the project and preparation of
the manuscript.
CR Agency for Healthcare Research and Quality, EFF HLTH CAR PROGR M
Amendah D., 2011, AUTISM SPECTRUM DISO, P1347
Autism and Developmental Disabilities Monitoring Network Surveillance Year 2008 Principal Investigators Centers for Disease Control and Prevention, 2012, MMWR SURVEILL SUMM, V61, P1
Bailey AJ, 2012, AUTISM RES, V5, P1, DOI 10.1002/aur.233
BallabanGil K, 1996, PEDIATR NEUROL, V15, P217, DOI 10.1016/S0887-8994(96)00219-6
Billstedt E, 2005, J AUTISM DEV DISORD, V35, P351, DOI 10.1007/s10803-005-3302-5
Cimera RE, 2009, AUTISM, V13, P285, DOI 10.1177/1362361309103791
Croen LA, 2006, PEDIATRICS, V118, pE1203, DOI 10.1542/peds.2006-0127
Eaves LC, 2008, J AUTISM DEV DISORD, V38, P739, DOI 10.1007/s10803-007-0441-x
Ganz ML, 2007, ARCH PEDIAT ADOL MED, V161, P343, DOI 10.1001/archpedi.161.4.343
Garcia-Villamisar D, 2000, J VOCATIONAL REHABIL, V14, P183
Garcia-Villamisar D., 2002, J VOCATIONAL REHABIL, V17, P309
Garcia-Villamisar D, 2007, J INTELL DISABIL RES, V51, P142, DOI 10.1111/j.1365-2788.2006.00854.x
Gurney JG, 2003, ARCH PEDIAT ADOL MED, V157, P622, DOI 10.1001/archpedi.157.7.622
Howlin P., 2005, HDB AUTISM PERVASIVE, V1, P201
Howlin P, 2005, AUTISM, V9, P533, DOI 10.1177/1362361305057871
Howlin P, 2004, J CHILD PSYCHOL PSYC, V45, P212, DOI 10.1111/j.1469-7610.2004.00215.x
Lawer L, 2009, J AUTISM DEV DISORD, V39, P487, DOI 10.1007/s10803-008-0649-4
Mawhood L, 1999, AUTISM INT J RES PRA, V3, P229, DOI DOI 10.1177/1362361399003003003
Office of Special Education Programs, IND DIS ACT IDEA DAT
Seltzer M. M., 2011, AUTISM SPECTRUM DISO, P241, DOI DOI 10.1093/MED/9780195371826.003.0016
Seltzer MM, 2004, MENT RETARD DEV D R, V10, P234, DOI 10.1002/mrdd.20038
Shattuck PT, 2011, ARCH PEDIAT ADOL MED, V165, P141, DOI 10.1001/archpediatrics.2010.279
Shattuck PT, 2012, PEDIATRICS, V129, P1042, DOI 10.1542/peds.2011-2864
Taylor JL, 2011, J AUTISM DEV DISORD, V41, P1397, DOI 10.1007/s10803-010-1166-9
Taylor JL, 2009, INT REV RES MENT RET, P2
Taylor JL, 2011, J AUTISM DEV DISORD, V41, P566, DOI 10.1007/s10803-010-1070-3
Taylor JL, 2010, J AUTISM DEV DISORD, V40, P1431, DOI 10.1007/s10803-010-1005-z
NR 28
TC 11
Z9 12
PU AMER ACAD PEDIATRICS
PI ELK GROVE VILLAGE
PA 141 NORTH-WEST POINT BLVD,, ELK GROVE VILLAGE, IL 60007-1098 USA
SN 0031-4005
J9 PEDIATRICS
JI Pediatrics
PD SEP
PY 2012
VL 130
IS 3
BP 531
EP 538
DI 10.1542/peds.2012-0682
PG 8
WC Pediatrics
SC Pediatrics
GA 014XO
UT WOS:000309409300056
PM 22926170
ER
PT J
AU Tostes, MHFS
Teixeira, HC
Gattaz, WF
Brandao, MAF
Raposo, NRB
AF Tostes, M. H. F. S.
Teixeira, H. C.
Gattaz, W. F.
Brandao, M. A. F.
Raposo, N. R. B.
TI Altered Neurotrophin, Neuropeptide, Cytokines and Nitric Oxide Levels in
Autism
SO PHARMACOPSYCHIATRY
LA English
DT Article
DE autism; children; VIP; NT-3; cytokines; nitric oxide
ID VASOACTIVE-INTESTINAL-PEPTIDE; CORTICOSPINAL NEURONS;
ELECTRICAL-ACTIVITY; NEONATAL BLOOD; DOWN-SYNDROME; IN-VIVO; CHILDREN;
SURVIVAL; ACTIVATION; MECHANISMS
AB Introduction: Modifications in neurotrophins, neuropeptides, cytokines and nitric oxide (NO) levels in autism may represent different biological aspects of the disease. In the present study we investigate simultaneously all these variables as an attempt to clarify their interrelationships in autism.
Methods: Plasma levels of vasoactive intestinal peptide (VIP), neurotrophin-3 (NT-3), cytokines and nitric oxide (NO) were determined in children with DSM-IV autistic disorder (n = 24) and in age- and gender-matched healthy controls (n = 24). VIP, NT-3, IFN-gamma and IL-1 beta levels were measured by ELISA, TNF-alpha, IL-10, IL-6, IL-4, IL-2 were evaluated by flow cytometry, and NO by Griess reaction.
Results: Plasma levels of VIP, IFN-gamma and NO were significantly higher and NT-3 plasma levels were significantly lower in children with autism, compared to the healthy subjects. In children with autism there was a positive correlation between plasma levels of NO and IFN-gamma.
Discussion: Our results indicate the presence of altered levels of neurotrophin and neuropeptide in infantile autism and provide additional evidence that higher levels of IFN-gamma may be associated with increased oxidative stress in autism.
C1 [Tostes, M. H. F. S.; Brandao, M. A. F.; Raposo, N. R. B.] Univ Fed Juiz de Fora, NUPICS NIQUA, BR-36036900 Juiz De Fora, MG, Brazil.
[Teixeira, H. C.] Univ Fed Juiz de Fora, Inst Biol Sci, Dept Parasitol Microbiol & Immunol, BR-36036900 Juiz De Fora, MG, Brazil.
[Gattaz, W. F.; Raposo, N. R. B.] Univ Sao Paulo, Fac Med, Dept & Inst Psychiat, Lab Neurosci, BR-05508 Sao Paulo, Brazil.
RP Raposo, NRB (reprint author), Univ Fed Juiz de Fora, NUPICS NIQUA, Rua Jose Lourenco Kelmer S-N,Campus Univ, BR-36036900 Juiz De Fora, MG, Brazil.
EM nadiafox@gmail.com
RI Gattaz, Wagner/C-4456-2012; RAPOSO, NADIA/N-6402-2013
OI RAPOSO, NADIA/0000-0001-5271-1048
CR Agerman K, 2003, NEUROREPORT, V14, P2183, DOI 10.1097/01.wnr.0000095710.83808.57
American Psychiatric Association (APA), 1994, DIAGN STAT MAN MENT, V4th
[Anonymous], 2000, 52 GEN ASS WMA 2000
Blondel O, 2000, J NEUROSCI, V20, P8012
Brenneman DE, 1999, ANN NY ACAD SCI, V897, P17, DOI 10.1111/j.1749-6632.1999.tb07875.x
BRENNEMAN DE, 1986, P NATL ACAD SCI USA, V83, P1159, DOI 10.1073/pnas.83.4.1159
Brenneman DE, 1996, J CLIN INVEST, V97, P2299, DOI 10.1172/JCI118672
Castren E, 2007, CURR OPIN PHARMACOL, V7, P18, DOI 10.1016/j.coph.2006.08.009
Chauhan Abha, 2006, Pathophysiology, V13, P171, DOI 10.1016/j.pathophys.2006.05.007
Croonenberghs J, 2002, NEUROPSYCHOBIOLOGY, V45, P1, DOI 10.1159/000048665
Delgado M, 2003, BIOCHEM BIOPH RES CO, V302, P275, DOI 10.1016/S0006-291X(03)00149-9
Duman RS, 2006, BIOL PSYCHIAT, V59, P1116, DOI 10.1016/j.biopsych.2006.02.013
Fernandes BS, 2010, J PSYCHIATR RES, V44, P561, DOI 10.1016/j.jpsychires.2009.11.020
Giehl KM, 2001, J NEUROSCI, V21, P3492
GREEN LC, 1982, ANAL BIOCHEM, V126, P131, DOI 10.1016/0003-2697(82)90118-X
Hindley S, 1997, J NEUROSCI RES, V47, P427
HOLSCHER C, 1992, NEUROSCI LETT, V145, P165, DOI 10.1016/0304-3940(92)90012-V
Jyonouchi H, 2001, J NEUROIMMUNOL, V120, P170, DOI 10.1016/S0165-5728(01)00421-0
Kato A, 2003, MOL BRAIN RES, V118, P33, DOI 10.1016/j.molbrainres.2003.07.005
Kovalchuk Y, 2004, CURR OPIN NEUROBIOL, V14, P558, DOI 10.1016/j.conb.2004.08.014
LONART G, 1992, EUR J PHARMACOL, V220, P271, DOI 10.1016/0014-2999(92)90759-W
Nelson KB, 2001, ANN NEUROL, V49, P597, DOI 10.1002/ana.1024
Nelson PG, 2006, INT J DEV NEUROSCI, V24, P73, DOI 10.1016/j.ijdevneu.2005.10.003
Nelson PG, 2001, J NEURAL TRANSM-SUPP, P85
Pan WH, 1998, NEUROPHARMACOLOGY, V37, P1553, DOI 10.1016/S0028-3908(98)00141-5
Sajdel-Sulkowska EM, 2009, CEREBELLUM, V8, P366, DOI 10.1007/s12311-009-0105-9
Sajdel-Sulkowska EM, 2010, Autism: Oxidative Stress, Inflammation, and Immune Abnormalities, P47
Schutte A, 2000, NEUROSCI LETT, V290, P185, DOI 10.1016/S0304-3940(00)01351-3
Segal RA, 2003, ANNU REV NEUROSCI, V26, P299, DOI 10.1146/annurev.neuro.26.041002.131421
Sherrard RM, 2002, CEREBELLUM, V1, P262
Sweeten TL, 2004, BIOL PSYCHIAT, V55, P434, DOI 10.1016/j.biopsych.200309.001
Tran MT, 2000, J IMMUNOL, V164, P4307
Truman JW, 1996, DEVELOPMENT, V122, P3949
Zoroglu SS, 2003, CELL BIOCHEM FUNCT, V21, P55, DOI 10.1002/cbf.989
NR 34
TC 11
Z9 12
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0176-3679
J9 PHARMACOPSYCHIATRY
JI Pharmacopsychiatry
PD SEP
PY 2012
VL 45
IS 6
BP 241
EP 243
DI 10.1055/s-0032-1301914
PG 3
WC Pharmacology & Pharmacy; Psychiatry
SC Pharmacology & Pharmacy; Psychiatry
GA 013QZ
UT WOS:000309321300006
PM 22426848
ER
PT J
AU Bransfield, RC
AF Bransfield, Robert C.
TI Relationship of Inflammation and Autoimmunity to Psychiatric Sequelae in
Lyme Disease
SO PSYCHIATRIC ANNALS
LA English
DT Article
ID BORRELIA-BURGDORFERI; DEPRESSIVE SYMPTOMS; CROSS-REACT;
NEUROBORRELIOSIS; ANTIBODIES; AUTISM; ALPHA; SPIROCHETE; INFECTION;
ANTIGENS
C1 [Bransfield, Robert C.] Robert Wood Johnson UMDNJ Med Sch, Piscataway, NJ 08854 USA.
RP Bransfield, RC (reprint author), 225 Highway 35, Red Bank, NJ 07701 USA.
EM Bransfield@comcast.net
CR Alaedini A, 2005, J NEUROIMMUNOL, V159, P192, DOI 10.1016/j.jneuroim.2004.10.014
Auwaerter Paul G., 2004, Expert Reviews in Molecular Medicine, V6, P1, DOI 10.1017/S1462399404007276
Bransfield R, 2011, 2 ILADS EUR M MAY 28
Bransfield R, 2012, OPEN NEUROL IN PRESS
Bransfield R, 2012, NEUROL PSYCHIAT BR, V18, P42
Bransfield RC, 2009, PEDIAT HLTH, V3, P125, DOI 10.2217/phe.09.5
Bransfield RC, 2008, MED HYPOTHESES, V70, P967, DOI 10.1016/j.mehy.2007.09.006
Carter C.J., 2011, J PATHOGENS, DOI [10.4061/2011/128318, DOI 10.4061/2011/128318]
Chong-Cerrillo C, 2001, INFECT IMMUN, V69, P4094, DOI 10.1128/IAI.69.6.4094-4102.2001
Coburn J, 2005, MOL MICROBIOL, V57, P1182, DOI 10.1111/j.1365-2958.2005.04759.x
Constant A, 2005, J CLIN PSYCHIAT, V66, P1050
Fallon BA, 2010, NEUROBIOL DIS, V37, P534, DOI 10.1016/j.nbd.2009.11.016
Goines P, 2010, CURR OPIN NEUROL, V23, P111, DOI 10.1097/WCO.0b013e3283373514
Greenberg HE, 1995, SLEEP, V18, P912
HALPERIN JJ, 1992, NEUROLOGY, V42, P43
Jarefors S, 2006, CLIN EXP IMMUNOL, V143, P322, DOI 10.1111/j.1365-2249.2005.02993.x
Kuhn M, 2012, MED HYPOTHESES, V78, P606, DOI 10.1016/j.mehy.2012.01.037
Lindqvist D, 2009, BIOL PSYCHIAT, V66, P287, DOI 10.1016/j.biopsych.2009.01.030
Miklossy J, 2011, J NEUROINFLAMM, V8, DOI 10.1186/1742-2094-8-90
Nicholson G, 2008, LAB MED, V39, P291
Pfister HW, 2006, INT J MED MICROBIOL, V296, P11, DOI 10.1016/j.ijmm.2005.12.003
Ramesh G, 2012, J NEUROINFLAMM, V9, DOI 10.1186/1742-2094-9-72
Rupprecht TA, 2008, MOL MED, V14, P205, DOI 10.2119/2007-00091.Rupprecht
SCHLUESENER HJ, 1989, AUTOIMMUNITY, V2, P323, DOI 10.3109/08916938908997158
Schramm F, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0040046
Shoemaker RC, 2008, INT ARCH ALLERGY IMM, V146, P255, DOI 10.1159/000116362
SIGAL LH, 1993, J INFECT DIS, V167, P1372
SIGAL LH, 1988, NEUROLOGY, V38, P1439
Wichers MC, 2005, MOL PSYCHIATR, V10, P538, DOI 10.1038/sj.mp.4001600
Widhe M, 2002, IMMUNOLOGY, V107, P46, DOI 10.1046/j.1365-2567.2002.01500.x
NR 30
TC 0
Z9 0
PU SLACK INC
PI THOROFARE
PA 6900 GROVE RD, THOROFARE, NJ 08086 USA
SN 0048-5713
J9 PSYCHIAT ANN
JI Psychiatr. Ann.
PD SEP
PY 2012
VL 42
IS 9
BP 337
EP 341
DI 10.3928/00485713-20120906-07
PG 5
WC Psychiatry
SC Psychiatry
GA 014ZF
UT WOS:000309413800007
ER
PT J
AU Antar, LN
Ferretti, CJ
Hollander, E
AF Antar, Laura N.
Ferretti, Casara Jean
Hollander, Eric
TI Immune Response and Inflammation in Autism Spectrum Disorder
SO PSYCHIATRIC ANNALS
LA English
DT Article
ID NEUROBIOLOGY; DYSFUNCTION; CHILDREN; BRAIN
C1 [Antar, Laura N.; Hollander, Eric] Montefiore Med Ctr, Albert Einstein Coll Med, Autist & Obsess Compuls Spectrum Program, Bronx, NY 10467 USA.
RP Antar, LN (reprint author), Montefiore Med Ctr, Albert Einstein Coll Med, Autist & Obsess Compuls Spectrum Program, 3307 Bainbridge Ave,Off 5, Bronx, NY 10467 USA.
EM lantar@montefiore.org
CR Abrahams BS, 2008, NAT REV GENET, V9, P341, DOI 10.1038/nrg2346
Angelidou A, 2011, J AUTISM DEV DISORD, V41, P1579, DOI 10.1007/s10803-010-1171-z
Angelidou A, 2012, BMC PEDIATR, V12, DOI 10.1186/1471-2431-12-89
[Anonymous], 2012, J NEUROINFLAMM, V9, P1
Ashwood P, 2006, J LEUKOCYTE BIOL, V80, P1, DOI 10.1189/jlb.1205707
Ashwood P, 2011, J NEUROIMMUNOL, V232, P196, DOI 10.1016/j.jneuroim.2010.10.025
Ashwood P, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0019299
Ashwood P, 2011, BRAIN BEHAV IMMUN, V25, P840, DOI 10.1016/j.bbi.2010.09.002
Autism and Developmental Disabilities Monitoring Network Surveillance Year 2008 Principal Investigators, 2012, MMWR SURVEILL SUMM, V61, P1
Campbel D, 2006, P NATL ACAD SCI USA, V102, P16834
Careaga M, 2010, NEUROTHERAPEUTICS, V7, P283, DOI 10.1016/j.nurt.2010.05.003
Chez MG, 2010, NEUROTHERAPEUTICS, V7, P293, DOI 10.1016/j.nurt.2010.05.008
Goines P, 2011, BRAIN BEHAV IMMUN, V25, P514, DOI 10.1016/j.bbi.2010.11.017
Li XH, 2009, J NEUROIMMUNOL, V207, P111, DOI 10.1016/j.jneuroim.2008.12.002
McAllister AK, 2009, NEURON, V64, P9, DOI 10.1016/j.neuron.2009.09.038
Onore C, 2012, BRAIN BEHAV IMMUN, V26, P383, DOI 10.1016/j.bbi.2011.08.007
Pardo CA, 2007, BRAIN PATHOL, V17, P434, DOI 10.1111/j.1750-3639.2007.00102.x
Pardo Carlos A, 2005, Int Rev Psychiatry, V17, P485, DOI 10.1080/02646830500381930
Rose S., 2012, TRANSL PSYCHIAT, V10, DOI DOI 10.1038/TP.2012.61
Rossi CC, 2011, BRAIN BEHAV IMMUN, V25, P1123, DOI 10.1016/j.bbi.2011.02.011
Ziats MN, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0024691
NR 21
TC 0
Z9 0
PU SLACK INC
PI THOROFARE
PA 6900 GROVE RD, THOROFARE, NJ 08086 USA
SN 0048-5713
J9 PSYCHIAT ANN
JI Psychiatr. Ann.
PD SEP
PY 2012
VL 42
IS 9
BP 342
EP 346
DI 10.3928/00485713-20120906-08
PG 5
WC Psychiatry
SC Psychiatry
GA 014ZF
UT WOS:000309413800008
ER
PT J
AU Henderson, BJ
Gonzalez-Cestari, TF
Yi, B
Pavlovicz, RE
Boyd, RT
Li, CL
Bergmeier, SC
McKay, DB
AF Henderson, Brandon J.
Gonzalez-Cestari, Tatiana F.
Yi, Bitna
Pavlovicz, Ryan E.
Boyd, R. Thomas
Li, Chenglong
Bergmeier, Stephen C.
McKay, Dennis B.
TI Defining the Putative Inhibitory Site for a Selective Negative
Allosteric Modulator of Human alpha 4 beta 2 Neuronal Nicotinic
Receptors
SO ACS CHEMICAL NEUROSCIENCE
LA English
DT Article
DE Negative allosteric modulator (NAM); neuronal nicotinic acetylcholine
receptors (nAChRs); alpha 4 beta 2; site-directed mutagenesis;
structure-activity relationships; nicotine
ID RING-E ANALOGS; ACETYLCHOLINE-RECEPTORS; SMOKING-CESSATION;
INTERNATIONAL UNION; PARTIAL AGONIST; ANTAGONISTS; METHYLLYCACONITINE;
VARENICLINE; SUBUNIT; NOMENCLATURE
AB Neuronal nicotinic receptors (nAChRs) have been implicated in several diseases and disorders such as autism spectrum disorders, Alzheimer's disease, Parkinson's disease, epilepsy, and nicotine addiction. To understand the role of nAChRs in these conditions, it would be beneficial to have selective molecules that target specific nAChRs in vitro and in vivo. Our laboratory has previously identified a novel allosteric site on human alpha 4 beta 2 nAChRs using a series of computational and in vitro approaches. At this site, we have identified negative allosteric modulators that selectively inhibit human alpha 4 beta 2 nAChRs, a subtype implicated in nicotine addiction. This study characterizes the allosteric site via site-directed mutagenesis. Three amino acids (Phe118, Glu60, and Thr58) on the beta 2 subunit were shown to participate in the inhibitory properties of the selective antagonist KAB-18 and provided insights into its antagonism of human alpha 4 beta 2 nAChRs. SAR studies with KAB-18 analogues and various mutant alpha 4 beta 2 nAChRs also provided information concerning how different physiochemical features influence the inhibition of nAChRs through this allosteric site. Together, these studies identify the amino acids that contribute to the selective antagonism of human alpha 4 beta 2 nAChRs at this allosteric site. Finally, these studies define the physiochemical features of ligands that influence interaction with specific amino acids in this allosteric site.
C1 [Gonzalez-Cestari, Tatiana F.; Yi, Bitna; McKay, Dennis B.] Ohio State Univ, Coll Pharm, Div Pharmacol, Columbus, OH 43210 USA.
[Henderson, Brandon J.] CALTECH, Div Biol, Pasadena, CA 91125 USA.
[Pavlovicz, Ryan E.] Ohio State Univ, Biophys Grad Program, Columbus, OH 43210 USA.
[Li, Chenglong] Ohio State Univ, Coll Pharm, Div Med Chem & Pharmacognosy, Columbus, OH 43210 USA.
[Boyd, R. Thomas] Ohio State Univ, Dept Neurosci, Columbus, OH 43210 USA.
[Bergmeier, Stephen C.] Ohio Univ, Dept Chem & Biochem, Athens, OH 45701 USA.
RP McKay, DB (reprint author), Ohio State Univ, Coll Pharm, Div Pharmacol, Columbus, OH 43210 USA.
FU National Institutes of Health National Institute on Drug Abuse
[DA029433]; National Institutes of Health National Institute on Drug
Abuse Diversity Supplement; American Foundation for Pharmaceutical
Education; Ohio Supercomputer Center
FX This work was supported by the National Institutes of Health National
Institute on Drug Abuse [Grant DA029433]. Financial support for B.J.H.
is from the National Institutes of Health National Institute on Drug
Abuse Diversity Supplement. Financial support for REP is from the
American Foundation for Pharmaceutical Education. A grant of
computational resources was received from the Ohio Supercomputer Center.
CR Albuquerque EX, 2009, PHYSIOL REV, V89, P73, DOI 10.1152/physrev.00015.2008
Arias HR, 2001, MOL PHARMACOL, V60, P497
Bergmeier SC, 1999, BIOORG MED CHEM LETT, V9, P2263, DOI 10.1016/S0960-894X(99)00378-9
Bergmeier SC, 2004, BIOORG MED CHEM LETT, V14, P3739, DOI 10.1016/j.bmcl.2004.05.001
Blum AP, 2010, P NATL ACAD SCI USA, V107, P13206, DOI 10.1073/pnas.1007140107
CORRIGALL WA, 1994, PHARMACOL BIOCHEM BE, V49, P67, DOI 10.1016/0091-3057(94)90457-X
Fiore MC, 2004, PREV MED, V38, P412, DOI 10.1016/j.ypmed.2003.11.002
Gonzalez-Cestari TF, 2009, J PHARMACOL EXP THER, V328, P504, DOI 10.1124/jpet.108.144576
Gotti C, 2006, NEUROBIOL DIS, V23, P481, DOI 10.1016/j.nbd.2006.04.005
Grady SR, 2010, NEUROPHARMACOLOGY, V58, P1054, DOI 10.1016/j.neuropharm.2010.01.013
Hamouda AK, 2009, BBA-BIOMEMBRANES, V1788, P1987, DOI 10.1016/j.bbamem.2009.06.012
Henderson BJ, 2012, BIOORG MED CHEM LETT, V22, P1797, DOI 10.1016/j.bmcl.2011.11.051
Henderson BJ, 2011, J MED CHEM, V54, P8681, DOI 10.1021/jm201294r
Henderson BJ, 2010, J PHARMACOL EXP THER, V334, P761, DOI 10.1124/jpet.110.168211
Huang J, 2008, BIOORGAN MED CHEM, V16, P3816, DOI 10.1016/j.bmc.2008.01.050
Improgo MRD, 2010, PROG NEUROBIOL, V92, P212, DOI 10.1016/j.pneurobio.2010.05.003
Jensen AA, 2005, J MED CHEM, V48, P4705, DOI 10.1021/jm040219e
Jozwiak K, 2007, J MED CHEM, V50, P6279, DOI 10.1021/jm070784s
Knight C, 2010, VALUE HEALTH, V13, P209, DOI 10.1111/j.1524-4733.2009.00672.x
Lloyd GK, 2000, J PHARMACOL EXP THER, V292, P461
Lopez-Hernandez GY, 2009, MOL PHARMACOL, V76, P652, DOI 10.1124/mol.109.056176
Lukas RJ, 1999, PHARMACOL REV, V51, P397
Mahasenan KV, 2011, ACS MED CHEM LETT, V2, P855, DOI 10.1021/ml2001714
Mihalak KB, 2006, MOL PHARMACOL, V70, P801, DOI 10.1124/mol.106.025130
Neubig RR, 2003, PHARMACOL REV, V55, P597, DOI 10.1124/pr.55.4.4
Pavlovicz RE, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0024949
Picciotto MR, 1998, NATURE, V391, P173
Rice ME, 2004, NAT NEUROSCI, V7, P583, DOI 10.1038/nn1244
Rollema H, 2007, NEUROPHARMACOLOGY, V52, P985, DOI 10.1016/j.neuropharm.2006.10.016
ROSE JE, 1994, CLIN PHARMACOL THER, V56, P86
Schuller HM, 2009, NAT REV CANCER, V9, P195, DOI 10.1038/nrc2590
Taly A, 2009, NAT REV DRUG DISCOV, V8, P733, DOI 10.1038/nrd2927
Tapper AR, 2004, SCIENCE, V306, P1029, DOI 10.1126/science.1099420
Taylor P, 2007, BIOCHEM PHARMACOL, V74, P1164, DOI 10.1016/j.bcp.2007.07.038
Watkins SS, 1999, PHARMACOL BIOCHEM BE, V62, P743, DOI 10.1016/S0091-3057(98)00226-3
Weltzin MM, 2010, J PHARMACOL EXP THER, V334, P917, DOI 10.1124/jpet.110.167684
Yoshimura RF, 2007, J PHARMACOL EXP THER, V323, P907, DOI 10.1124/jpet.107.128751
NR 37
TC 1
Z9 1
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1948-7193
J9 ACS CHEM NEUROSCI
JI ACS Chem. Neurosci.
PD SEP
PY 2012
VL 3
IS 9
BP 682
EP 692
DI 10.1021/cn300035f
PG 11
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Neurosciences
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Neurosciences
& Neurology
GA 009HI
UT WOS:000309016500007
PM 23019495
ER
PT J
AU Chung, YC
Carter, EW
Sisco, LG
AF Chung, Yun-Ching
Carter, Erik W.
Sisco, Lynn G.
TI Social Interactions of Students with Disabilities Who Use Augmentative
and Alternative Communication in Inclusive Classrooms
SO AJIDD-AMERICAN JOURNAL ON INTELLECTUAL AND DEVELOPMENTAL DISABILITIES
LA English
DT Article
DE social interaction; augmentative and alternative communication;
paraprofessionals; inclusive education; severe disabilities
ID HIGH-SCHOOL-STUDENTS; DEVELOPMENTAL-DISABILITIES; PEER INTERACTIONS;
INTELLECTUAL DISABILITIES; MULTIPLE DISABILITIES; INTERVENTION RESEARCH;
LITERACY INSTRUCTION; MENTAL-RETARDATION; CEREBRAL-PALSY; CHILDREN
AB The purpose of this study was to explore the naturally occurring social interactions for students with disabilities who use augmentative and alternative communication (AAC) in general education classrooms. We observed 16 students who used AAC and received services under the categories of autism or intellectual disability. Participants primarily interacted with their support personnel and infrequently conversed with peers despite often being in close proximity. Few interaction episodes were initiated by students who used AAC, and initiations to peers and adults appeared to serve somewhat different functions. Students with disabilities relied more heavily on facial expressions and gestures than on the use of their AAC devices. Recommendations for promoting interaction opportunities among students are offered, and future research directions are suggested.
C1 [Chung, Yun-Ching] Illinois State Univ, Normal, IL 61790 USA.
[Carter, Erik W.] Vanderbilt Univ, Nashville, TN USA.
[Sisco, Lynn G.] Univ Wisconsin, Madison, WI 53706 USA.
RP Chung, YC (reprint author), Illinois State Univ, 516 DeGarmo Hall,Campus Box 5910, Normal, IL 61790 USA.
EM ychung@ilstu.edu
CR Arthur-Kelly M, 2007, J DEV PHYS DISABIL, V19, P161, DOI 10.1007/s10882-007-9045-9
Beck A. R., 2009, PERSPECTIVES AUGMENT, V18, P96
Beukelman D., 2005, AUGMENTATIVE ALTERNA, V3rd
Bingham MA, 2007, EDUC TRAIN DEV DISAB, V42, P339
Blackstone S., 1991, TECHNOLOGY CLASSROOM, pE1
Blackstone S., 2003, SOCIAL NETWORKS COMM
Brown L., 1977, AAESPH REV, V2, P195
Bukowski WM, 2009, HDB PEER INTERACTION, P217
Calculator SN, 2009, INT J INCLUSIVE EDUC, V13, P93, DOI 10.1080/13603110701284656
Carter E, 2009, REM SPEC EDUC, V30, P344, DOI 10.1177/0741932508324399
Carter EW, 2010, RES PRACT PERS SEV D, V35, P63
Carter EW, 2005, AM J MENT RETARD, V110, P366, DOI 10.1352/0895-8017(2005)110[366:FISIAH]2.0.CO;2
Carter EW, 2008, AM J MENT RETARD, V113, P479, DOI 10.1352/2008.113:479-494
Causton-Theoharis J. N., 2009, TEACHING EXCEPTIONAL, V42, P36
Clarke M, 2007, AUGMENT ALTERN COMM, V23, P336, DOI 10.1080/07434610701739929
Cutts S, 2001, J INTELLECT DEV DIS, V26, P127
Davis CA, 1998, J ASSOC PERS SEVERE, V23, P57, DOI 10.2511/rpsd.23.1.57
Downing JE, 2005, AUGMENT ALTERN COMM, V21, P132, DOI 10.1080/07434610500103582
Giangreco MF, 2009, INTELLECT DEV DISAB, V47, P53, DOI 10.1352/2009.47:53-56
Giangreco MF, 2001, EXCEPT CHILDREN, V68, P45
Hall LJ, 2000, J SPEC EDUC, V34, P114, DOI 10.1177/002246690003400301
Hunt P., 2002, AUGMENTATIVE ALTERNA, V18, P20, DOI [10.1080/aac.18.1.20.35, DOI 10.1080/AAC.18.1.20.35]
HUNT P, 1991, AAC (Augmentative and Alternative Communication), V7, P117, DOI 10.1080/07434619112331275783
Hustad KC, 2007, FOLIA PHONIATR LOGO, V59, P306, DOI 10.1159/000108337
Jackson LB, 2008, RES PRACT PERS SEV D, V33-34, P175
Keigher A., 2009, CHARACTERISTICS PUBL
KOPPENHAVER DA, 1993, TOP LANG DISORD, V13, P1
Koppenhaver David A., 2007, Seminars in Speech and Language, V28, P79, DOI 10.1055/s-2007-967932
Lancioni GE, 2007, RES DEV DISABIL, V28, P468, DOI 10.1016/j.ridd.2006.06.003
Lee SH, 2009, J SPEC EDUC, V43, P29, DOI 10.1177/0022466907313449
Light J, 1988, AUGMENTATIVE ALTERNA, V4, P66, DOI [10.1080/07434618812331274657, DOI 10.1080/07434618812331274657]
Light J. C., 2002, EXEMPLARY PRACTICES, P187
Lilienfeld M, 2005, AUGMENT ALTERN COMM, V21, P278, DOI 10.1080/07434610500103467
Causton-Theoharis JN, 2005, EXCEPT CHILDREN, V71, P431
Matheson C, 2007, AM J MENT RETARD, V112, P319, DOI 10.1352/0895-8017(2007)112[0319:AGFIHT]2.0.CO;2
McCarthy J, 2005, AUGMENT ALTERN COMM, V21, P41, DOI 10.1080/07434640410001699753
Pufpaff LA, 2008, PSYCHOL SCHOOLS, V45, P582, DOI 10.1002/pits.20311
Rehm Roberta S, 2006, J Pediatr Nurs, V21, P299, DOI 10.1016/j.pedn.2006.02.003
ROMSKI MA, 1994, AM J MENT RETARD, V98, P527
Rubin K., 2009, HDB PEER INTERACTION
Schlosser RW, 2008, AM J SPEECH-LANG PAT, V17, P212, DOI 10.1044/1058-0360(2008/021)
Schnorr RF, 1997, J ASSOC PERS SEVERE, V22, P1
Siegel-Causey E., 1997, FOCUS AUTISM OTHER D, V12, P105, DOI 10.1177/108835769701200206
Simpson K, 2000, AUGMENTATIVE ALTERNA, V16, P107, DOI 10.1080/07434610012331278944
Snell ME, 2006, RES PRACT PERS SEV D, V31, P203
Snell ME, 2010, AJIDD-AM J INTELLECT, V115, P364, DOI 10.1352/1944-7558-115-5.364
Sonnenmeier RM, 2005, AUGMENT ALTERN COMM, V21, P101, DOI 10.1080/07434610500103608
Stoner JB, 2010, AUGMENT ALTERN COMM, V26, P122, DOI 10.3109/07434618.2010.481092
United States Department of Education, 2009, 28 US DEP ED
Wagner M., 2002, OTHER 80 THEIR TIME
Webster AA, 2007, J INTELLECT DEV DIS, V32, P200, DOI 10.1080/13668250701549443
Wentzel K. R., 2009, HDB PEER INTERACTION, P531, DOI DOI 10.1007/S10803-009-0830-4
WILKINSON KM, 1995, J SPEECH HEAR RES, V38, P1045
Wilkinson KM, 2007, MENT RETARD DEV D R, V13, P58, DOI 10.1002/mrdd.20133
NR 54
TC 11
Z9 12
PU AMER ASSOC INTELLECTUAL DEVELOPMENTAL DISABILITIES
PI WASHINGTON
PA 444 N CAPITOL ST, NW STE 846, WASHINGTON, DC 20001-1512 USA
SN 1944-7515
J9 AJIDD-AM J INTELLECT
JI AJIDD-Am. J. Intellect. Dev. Disabil.
PD SEP
PY 2012
VL 117
IS 5
BP 349
EP 367
DI 10.1352/1944-7558-117.5.349
PG 19
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA 009NW
UT WOS:000309033500002
PM 22998484
ER
PT J
AU Glaser, B
Lothe, A
Chabloz, M
Dukes, D
Pasca, C
Redoute, J
Eliez, S
AF Glaser, Bronwyn
Lothe, Amelie
Chabloz, Melanie
Dukes, Daniel
Pasca, Catherine
Redoute, Jerome
Eliez, Stephan
TI Candidate Socioemotional Remediation Program for Individuals with
Intellectual Disability
SO AJIDD-AMERICAN JOURNAL ON INTELLECTUAL AND DEVELOPMENTAL DISABILITIES
LA English
DT Article
DE cognitive remediation; face processing; emotion recognition; Vis-a-Vis
ID 22Q11.2 DELETION SYNDROME; FACIAL AFFECT RECOGNITION; AUTISM SPECTRUM
DISORDER; HIGH-FUNCTIONING AUTISM; SCHOOL-AGE-CHILDREN;
ASPERGER-SYNDROME; TRAINING-PROGRAM; WORKING-MEMORY; COGNITIVE
REMEDIATION; EXECUTIVE FUNCTIONS
AB The authors developed a computerized program, Vis-a-Vis (VAV), to improve socio-emotional functioning and working memory in children with developmental disabilities. The authors subsequently tested whether participants showed signs of improving the targeted skills. VAV is composed of three modules: Focus on the Eyes, Emotion Recognition and Understanding, and Working Memory. Ten children with idiopathic developmental delay completed four 20-min weekly sessions of VAV for 12 weeks with an adult. Participants were evaluated before (Time 0) and after (Time 1) training and 6 months after remediation (Time 2). Subjects improved on all three modules during training and on emotion recognition and nonverbal reasoning post-VAV. These gains were still present at Time 2. VAV is a promising new tool for working on socioemotional impairments in hard-to-treat pediatric populations.
C1 [Glaser, Bronwyn] Univ Geneva, Sch Med, OMP, Res Unit, CH-1211 Geneva 8, Gva, Switzerland.
[Lothe, Amelie; Redoute, Jerome] CERMEP, Lyon, France.
[Dukes, Daniel] Univ Neuchatel, Ctr Cognit Sci, CH-2000 Neuchatel, Switzerland.
RP Glaser, B (reprint author), Univ Geneva, Sch Med, OMP, Res Unit, 1 Rue David Dufour, CH-1211 Geneva 8, Gva, Switzerland.
EM bronwyn.glaser@unige.ch
CR Adolphs R, 2005, NATURE, V433, P68, DOI 10.1038/nature03086
Annaz D, 2009, J EXP CHILD PSYCHOL, V102, P456, DOI 10.1016/j.jecp.2008.11.005
BADDELEY A, 1994, NEUROPSYCHOLOGIA, V32, P53, DOI 10.1016/0028-3932(94)90068-X
Baron-Cohen S, 2001, J CHILD PSYCHOL PSYC, V42, P241, DOI 10.1017/S0021963001006643
Behrmann M, 2006, NEUROPSYCHOLOGIA, V44, P110, DOI 10.1016/j.neuropsychologia.2005.04.002
Benton A.L., 1994, CONTRIBUTIONS NEUROP
Bloom E, 2010, J LEARN DISABIL-US, V43, P180, DOI 10.1177/0022219409345014
Bölte Sven, 2002, Int J Circumpolar Health, V61 Suppl 2, P61
Campbell L, 2010, PSYCHIAT RES, V177, P211, DOI 10.1016/j.psychres.2009.06.007
Caviola S., 2009, INT ELECT J ELEMENTA, V2, P122
CHEN SHA, 1993, MENT RETARD, V31, P368
Cohen M. J., 1997, CMS ECHELLE MEMOIRE
Deruelle C, 2004, J AUTISM DEV DISORD, V34, P199, DOI 10.1023/B:JADD.0000022610.09668.4c
Ekman P., 1976, PICTURES FACIAL AFFE
EKMAN P, 1971, J PERS SOC PSYCHOL, V17, P124, DOI 10.1037/h0030377
Faja S, 2008, DEV NEUROPSYCHOL, V33, P1, DOI 10.1080/87565640701729573
Fox J, 2004, J YOUNG INVESTIGATOR, V10
Frommann N, 2003, PSYCHIAT RES, V117, P281, DOI 10.1016/S0165-1781(03)00039-8
Glaser B, 2010, J AM ACAD CHILD PSY, V49, P665, DOI 10.1016/j.jaac.2010.04.004
Gogtay N, 2004, P NATL ACAD SCI USA, V101, P8174, DOI 10.1073/pnas.0402680101
Golan O, 2006, DEV PSYCHOPATHOL, V18, P591, DOI 10.1017/S0954579406060305
Golan O, 2010, J AUTISM DEV DISORD, V40, P269, DOI 10.1007/s10803-009-0862-9
Golan O, 2008, J AUTISM DEV DISORD, V38, P1534, DOI 10.1007/s10803-007-0533-7
GoldmanRakic PS, 1996, PHILOS T ROY SOC B, V351, P1445, DOI 10.1098/rstb.1996.0129
Gray C., 1995, TEACHING CHILDREN AU, P219
Gray C. A., 2000, NEW SOCIAL STORYBOOK
Grinspan D, 2003, J GENET PSYCHOL, V164, P88
Hernandez N, 2009, NEUROPSYCHOLOGIA, V47, P1004, DOI 10.1016/j.neuropsychologia.2008.10.023
Hopkins IM, 2011, J AUTISM DEV DISORD, V41, P1543, DOI 10.1007/s10803-011-1179-z
Huttinger P. L., 1996, FOCUS AUTISM OTHER D, V11, P105
Karmiloff-Smith A, 2004, J CHILD PSYCHOL PSYC, V45, P1258, DOI 10.1111/j.1469-7610.2004.00322.x
Klin A, 2002, ARCH GEN PSYCHIAT, V59, P809, DOI 10.1001/archpsyc.59.9.809
Klingberg T, 2002, J CLIN EXP NEUROPSYC, V24, P781, DOI 10.1076/jcen.24.6.781.8395
Klingberg T, 2002, J COGNITIVE NEUROSCI, V14, P1, DOI 10.1162/089892902317205276
Klingberg T, 2005, J AM ACAD CHILD PSY, V44, P177, DOI 10.1097/00004583-200502000-00010
Kovacs M, 1982, CHILDRENS DEPRESSION
Kuoch H., 2003, FOCUS AUTISM OTHER D, V18, P219, DOI DOI 10.1177/10883576030180040301
Lacroix A, 2009, RES DEV DISABIL, V30, P976, DOI 10.1016/j.ridd.2009.02.002
Lieberman MD, 2007, PSYCHOL SCI, V18, P421, DOI 10.1111/j.1467-9280.2007.01916.x
Mazzola F, 2006, SOC NEUROSCI, V1, P259, DOI 10.1080/17470910600989912
MCALPINE C, 1991, AM J MENT RETARD, V96, P29
Medalia A, 2009, NEUROPSYCHOL REV, V19, P353, DOI 10.1007/s11065-009-9097-y
Mondloch CJ, 2002, PERCEPTION, V31, P553, DOI 10.1068/p3339
Monette S, 2011, J EXP CHILD PSYCHOL, V109, P158, DOI 10.1016/j.jecp.2011.01.008
Olesen PJ, 2004, NAT NEUROSCI, V7, P75, DOI 10.1038/nn1165
Penn DL, 2000, SCHIZOPHR RES, V46, P217, DOI 10.1016/S0920-9964(00)00005-0
Pennington BF, 1996, J CHILD PSYCHOL PSYC, V37, P51, DOI 10.1111/j.1469-7610.1996.tb01380.x
PREMACK D, 1978, SCIENCE, V202, P532, DOI 10.1126/science.705342
Raven JC, 1998, RAVENS COLOURED PROG
Reynolds C. R. R., 1985, R CMAS ECHELLE REVIS
Russell TA, 2008, SCHIZOPHR RES, V103, P248, DOI 10.1016/j.schres.2008.04.033
Sanz DG, 2009, SPAN J PSYCHOL, V12, P184
Sartory G, 2005, SCHIZOPHR RES, V75, P219, DOI 10.1016/j.schres.2004.10.004
Schunk D. H., 2007, MOTIVATION SELF REGU
Senju A, 2009, TRENDS COGN SCI, V13, P127, DOI 10.1016/j.tics.2008.11.009
SIDMAN M, 1967, J EXP ANAL BEHAV, V10, P3, DOI 10.1901/jeab.1967.10-3
Silver H, 2004, PSYCHIAT RES, V128, P147, DOI 10.1016/j.psychres.2004.06.002
Silver M, 2001, AUTISM, V5, P299, DOI 10.1177/1362361301005003007
Smith C., 2001, ED PSYCHOL PRACTICE, V17, P337, DOI 10.1080/02667360127230
STEWART CA, 1995, RES DEV DISABIL, V16, P365, DOI 10.1016/0891-4222(95)00024-H
Swaggart B. L., 1995, FOCUS AUTISTIC BEHAV, V10, P1
Tanaka JW, 2010, J CHILD PSYCHOL PSYC, V51, P944, DOI 10.1111/j.1469-7610.2010.02258.x
Taylor MJ, 2004, J COGNITIVE NEUROSCI, V16, P1426, DOI 10.1162/0898929042304732
van Rijn S., 2010, PSYCHOL MED, V41, P499
Vicari S, 2000, ACTA PAEDIATR, V89, P836, DOI 10.1080/080352500750043756
Vuilleumier P, 2003, NAT NEUROSCI, V6, P624, DOI 10.1038/nn1057
Wasserstein J, 2001, ANN NY ACAD SCI, V931, P376
Wechsler D., 2005, ECHELLE INTELLIGENCE
Wolf JM, 2008, AUTISM RES, V1, P329, DOI 10.1002/aur.56
Wolwer W, 2005, SCHIZOPHR RES, V80, P295, DOI 10.1016/j.schres.2005.07.018
Worsdell AS, 2005, J APPL BEHAV ANAL, V38, P511, DOI 10.1901/jaba.2005.115-04
Wykes T, 2002, BRIT J PSYCHIAT, V181, P144
Zaja RH, 2008, CURR OPIN PSYCHIATR, V21, P441, DOI 10.1097/YCO.0b013e328305e5fd
NR 73
TC 2
Z9 2
PU AMER ASSOC INTELLECTUAL DEVELOPMENTAL DISABILITIES
PI WASHINGTON
PA 444 N CAPITOL ST, NW STE 846, WASHINGTON, DC 20001-1512 USA
SN 1944-7515
J9 AJIDD-AM J INTELLECT
JI AJIDD-Am. J. Intellect. Dev. Disabil.
PD SEP
PY 2012
VL 117
IS 5
BP 368
EP 383
DI 10.1352/1944-7558-117.5.368
PG 16
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA 009NW
UT WOS:000309033500003
PM 22998485
ER
PT J
AU Martin, GE
Roberts, JE
Helm-Estabrooks, N
Sideris, J
Vanderbilt, J
Moskowitz, L
AF Martin, Gary E.
Roberts, Joanne E.
Helm-Estabrooks, Nancy
Sideris, John
Vanderbilt, Jacqueline
Moskowitz, Lauren
TI Perseveration in the Connected Speech of Boys with Fragile X Syndrome
with and Without Autism Spectrum Disorder
SO AJIDD-AMERICAN JOURNAL ON INTELLECTUAL AND DEVELOPMENTAL DISABILITIES
LA English
DT Article
DE Fragile X syndrome; autism; Down syndrome; perseveration; X-linked
ID DEVELOPMENTAL LANGUAGE DISORDERS; MENTAL-RETARDATION PROTEIN;
DOWN-SYNDROME; YOUNG-CHILDREN; EXPRESSIVE LANGUAGE; SAMPLING CONTEXT;
MALES; BEHAVIOR; SKILLS; COMMUNICATION
AB Verbal perseveration is a frequently reported language characteristic of males with Fragile X syndrome and may be a defining feature or hallmark of the syndrome. We compared the verbal perseveration of boys with Fragile X syndrome with (n = 29) and without (n = 30) autism spectrum disorder, boys with Down syndrome (n = 27), and typically developing boys (n = 25) at similar nonverbal mental ages. During a social interaction, boys with both Fragile X syndrome and autism spectrum disorder produced significantly more topic perseveration than all other groups. In social interaction as compared to narration, boys with Fragile X syndrome (regardless of autism status) produced significantly more topic perseveration. These findings suggest that autism status, as well as language sampling context, affect perseveration in boys with Fragile X syndrome.
C1 [Martin, Gary E.; Roberts, Joanne E.; Sideris, John; Vanderbilt, Jacqueline] Univ N Carolina, Frank Porter Graham Child Dev Inst, Chapel Hill, NC 27599 USA.
[Helm-Estabrooks, Nancy] Western Carolina Univ, Cullowhee, NC USA.
[Moskowitz, Lauren] SUNY Stony Brook, Stony Brook, NY USA.
RP Martin, GE (reprint author), Univ N Carolina, Frank Porter Graham Child Dev Inst, 105 Smith Level Rd,CB 8180, Chapel Hill, NC 27599 USA.
EM gary.martin@unc.edu
CR Abbeduto L, 1997, MENT RETARD DEV D R, V3, P313, DOI 10.1002/(SICI)1098-2779(1997)3:4<313::AID-MRDD6>3.0.CO;2-O
Abbeduto L, 2007, MENT RETARD DEV D R, V13, P36, DOI 10.1002/mrdd.20142
ABBEDUTO L, 1995, MENT RETARD, V33, P279
American Psychiatric Association, 2000, DIAGN STAT MAN MENT
Bailey DB, 2001, J AUTISM DEV DISORD, V31, P165
Baker M. J., 2000, J POSIT BEHAV INTERV, V2, P66, DOI 10.1177/109830070000200201
Belser RC, 1995, DEV BRAIN DYSFUNCT, V8, P270
Bennetto L., 2002, FRAGILE X SYNDROME D, V3
BREGMAN JD, 1988, J AUTISM DEV DISORD, V18, P343, DOI 10.1007/BF02212191
Bryk A. S., 1992, HIERARCHICAL LINEAR
Burchinal M. R., 2006, MONOGRAPHS SOC RES C, V71, P65, DOI [DOI 10.1111/J.1540-5834.2006.00405.X, 10.1111/j.1540-5834.2006.00405.x]
Clifford S, 2007, J AUTISM DEV DISORD, V37, P738, DOI 10.1007/s10803-006-0205-z
Coffee B, 2009, AM J HUM GENET, V85, P503, DOI 10.1016/j.ajhg.2009.09.007
COHEN J, 1960, EDUC PSYCHOL MEAS, V20, P37, DOI 10.1177/001316446002000104
Cordeiro L, 2011, J NEURODEV DISORD, V3, P57, DOI 10.1007/s11689-010-9067-y
Cornish K, 2004, MENT RETARD DEV D R, V10, P11, DOI 10.1002/mrdd.20003
Crowley J., 1994, RENFREW BUS STORY
DOLLAGHAN CA, 1990, J SPEECH HEAR DISORD, V55, P582
Dykens E. M., 2000, GENETICS MENTAL RETA
Estigarribia B, 2011, APPL PSYCHOLINGUIST, V32, P359, DOI 10.1017/S0142716410000445
Fernandez-Carvajal I, 2009, J MOL DIAGN, V11, P324, DOI 10.2353/jmoldx.2009.080173
FERRIER LJ, 1991, DEV MED CHILD NEUROL, V33, P776
Finestack LH, 2009, TOP LANG DISORD, V29, P133
FLEISS JL, 1981, APPL PSYCH MEAS, V5, P105, DOI 10.1177/014662168100500115
FRYNS JP, 1984, CLIN GENET, V25, P131
Hagerman PJ, 2008, J MED GENET, V45, P498, DOI 10.1136/jmg.2008.059055
Hagerman R. J., 2002, FRAGILE X SYNDROME D
Hagerman R.J., 2002, FRAGILE X SYNDROME D, P3
Hall SS, 2008, AM J MENT RETARD, V113, P44, DOI 10.1352/0895-8017(2008)113[44:CSAABI]2.0.CO;2
HANSON DM, 1986, AM J MED GENET, V23, P195, DOI 10.1002/ajmg.1320230114
Helm-Estabrooks N, 2004, MANUAL APHASIA APHAS, V2nd
Hessl D., 2001, PEDIATRICS, V108, P88
Hooper SR, 2000, J PSYCHOEDUC ASSESS, V18, P255, DOI 10.1177/073428290001800305
Kaufmann WE, 2004, AM J MED GENET A, V129A, P225, DOI 10.1002/ajmg.a.30229
KOEGEL RL, 1993, J APPL BEHAV ANAL, V26, P369, DOI 10.1901/jaba.1993.26-369
LANDIS JR, 1977, BIOMETRICS, V33, P159, DOI 10.2307/2529310
Levy Y, 2006, J CHILD LANG, V33, P125, DOI 10.1017/S030500090500718X
Loesch DZ, 2002, J DEV BEHAV PEDIATR, V23, P416
Loesch DZ, 2003, NEUROPSYCHOLOGY, V17, P646, DOI 10.1037/0894-4105.17.4.646
LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
Lord C., 2001, AUTISM DIAGNOSTIC OB
MacWhinney B., 1995, CHILDES PROJECT TOOL
MADISON LS, 1986, J MENT DEFIC RES, V30, P129
McDuffie A., 2008, SPEECH LANGUAGE DEV
Miller J., 2008, SYSTEMATIC ANAL LANG
Murphy MM, 2007, J INTELL DISABIL RES, V51, P387, DOI 10.1111/j.1365-2788.2006.00888.x
Philofsky A, 2004, AM J MENT RETARD, V109, P208, DOI 10.1352/0895-8017(2004)109<208:LACFAA>2.0.CO;2
PROUTY LA, 1988, AM J MED GENET, V30, P123, DOI 10.1002/ajmg.1320300111
Reiss AL, 2003, DEV PSYCHOPATHOL, V15, P927, DOI 10.1017/S0954579403000464
Rice ML, 2005, APPL PSYCHOLINGUIST, V26, P7, DOI 10.1017/S0142716405050034
Rispoli M, 2001, J SPEECH LANG HEAR R, V44, P1131, DOI 10.1044/1092-4388(2001/089)
Roberts J, 2007, AM J MENT RETARD, V112, P177, DOI 10.1352/0895-8017(2007)112[177:RVEVAS]2.0.CO;2
Roberts J, 2007, J SPEECH LANG HEAR R, V50, P475, DOI 10.1044/1092-4388(2007/033)
Roberts J. E., 2008, SPEECH LANGUAGE DEV, P77
Roberts J. E., 2008, SPEECH LANGUAGE DEV
Rogers SJ, 2001, J DEV BEHAV PEDIATR, V22, P409
Roid G., 1997, LEITER INT PERFORMAN
Ross DE, 2002, EDUC TRAIN MENT RET, V37, P343
Scharfenaker S., 2002, FRAGILE X SYNDROME D, P363
SUDHALTER V, 1991, AM J MED GENET, V38, P493, DOI 10.1002/ajmg.1320380270
SUDHALTER V, 1990, AM J MENT RETARD, V94, P431
Tager-Flusberg H, 2005, APPL PSYCHOLINGUIST, V26, P29, DOI 10.1017/S0142716405050046
Tager-Flusberg H, 2009, J SPEECH LANG HEAR R, V52, P643, DOI 10.1044/1092-4388(2009/08-0136)
Thordardottir E, 2008, J SPEECH LANG HEAR R, V51, P922, DOI 10.1044/1092-4388(2008/068)
Wilding J, 2002, NEUROPSYCHOLOGIA, V40, P1343, DOI 10.1016/S0028-3932(01)00212-3
Wolf-Schein E G, 1987, ASHA, V29, P35
NR 66
TC 4
Z9 4
PU AMER ASSOC INTELLECTUAL DEVELOPMENTAL DISABILITIES
PI WASHINGTON
PA 444 N CAPITOL ST, NW STE 846, WASHINGTON, DC 20001-1512 USA
SN 1944-7515
J9 AJIDD-AM J INTELLECT
JI AJIDD-Am. J. Intellect. Dev. Disabil.
PD SEP
PY 2012
VL 117
IS 5
BP 384
EP 399
DI 10.1352/1944-7558-117.5.384
PG 16
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA 009NW
UT WOS:000309033500004
PM 22998486
ER
PT J
AU Ledford, JR
Lane, JD
Elam, KL
Wolery, M
AF Ledford, Jennifer R.
Lane, Justin D.
Elam, Katherine L.
Wolery, Mark
TI Using Response-prompting Procedures During Small-group Direct
Instruction: Outcomes and Procedural Variations
SO AJIDD-AMERICAN JOURNAL ON INTELLECTUAL AND DEVELOPMENTAL DISABILITIES
LA English
DT Article
DE direct instruction; prompting procedures; small group; discrete
behaviors
ID CONSTANT TIME-DELAY; AUTISM SPECTRUM DISORDERS; SINGLE-SUBJECT RESEARCH;
SMART BOARD TECHNOLOGY; SPECIAL-EDUCATION; ATTENTIONAL RESPONSES; WORD
RECOGNITION; SEVERE HANDICAPS; STUDENTS; DISABILITIES
AB Research was reviewed on small-group instruction for learners with disabilities. The review was conducted for articles published between 1990 and 2010 on the application of small-group direct instruction to teach discrete skills using prompting procedures. A total of 47 articles with 197 participants and 687 replications of effects was located. Small-group instruction was effective for 195 of 197 participants and across variations in implementation and contexts. Implementers were primarily special education personnel, and instruction typically occurred in special education settings. Rigorous designs were used in all studies, and fidelity was assessed in 46 of 47 studies and was uniformly high. Students consistently reached criterion on their own target behaviors, generalized those behaviors, maintained them, and learned the behaviors taught to their peers (when this was measured, which occurred in a majority of the studies). Future research should examine comparisons of procedural variables and promoting social behaviors between group mates.
C1 [Ledford, Jennifer R.] Vanderbilt Peabody Coll, Dept Special Educ, Nashville, TN 37203 USA.
[Lane, Justin D.] Univ Georgia, Athens, GA 30602 USA.
[Elam, Katherine L.] Metropolitan Nashville Publ Sch, Nashville, TN USA.
RP Ledford, JR (reprint author), Vanderbilt Peabody Coll, Dept Special Educ, Box 228, Nashville, TN 37203 USA.
EM jennifer.ledford@vanderbilt.edu
RI Ledford, Jennifer/G-7455-2014
CR Alig-Cybriwsky C., 1990, J EARLY INTERVENTION, V14, P99
Anthony L., 1996, J BEHAV ED, V6, P111, DOI 10.1007/BF02110228
AULT MJ, 1990, LEARN DISABILITY Q, V13, P12, DOI 10.2307/1510389
Bandura A., 1977, SOCIAL LEARNING THEO
Beretvas SN, 2008, EVIDENCE BASED COMMU, V2, P129, DOI DOI 10.1080/17489530802446302
BIRNBRAUER JS, 1981, ANAL INTERVEN DEVEL, V1, P117, DOI 10.1016/0270-4684(81)90026-4
Bitterman A, 2008, J AUTISM DEV DISORD, V38, P1509, DOI 10.1007/s10803-007-0531-9
Brown F., 1980, J ASS SEVERLY HANDI, V5, P352
Campbell ML, 2009, REM SPEC EDUC, V30, P47, DOI 10.1177/0741932508315048
Chiara L, 1995, J EARLY INTERVENTION, V19, P203
Coleman-Martin MB, 2004, J APPL BEHAV ANAL, V37, P469, DOI 10.1901/jaba.2004.37-469
Collins B. C., 1994, EXCEPTIONALITY, V5, P163
COLLINS BC, 1991, EDUC TRAIN MENT RET, V26, P18
Colozzi GA, 2008, EDUC TRAIN DEV DISAB, V43, P226
Colvin G., 1993, ED TREATMENT CHILDRE, V16, P361
Cooper J. O., 2007, APPL BEHAV ANAL
Cromer K., 1998, J BEHAV ED, V8, P37, DOI 10.1023/A:1022812723663
Doyle P. M., 1992, EXCEPTIONALITY, V2, P233
DOYLE PM, 1988, J ASSOC PERS SEVERE, V13, P28
DOYLE PM, 1990, J SPEC EDUC, V23, P369
Drasgow E, 2011, HANDBOOK OF SPECIAL EDUCATION, P516
Dymond SK, 2004, EDUC TRAIN DEV DISAB, V39, P127
Elbaum B, 1999, EXCEPT CHILDREN, V65, P399
Falkenstine KJ, 2009, EDUC TRAIN DEV DISAB, V44, P127
FARMER JA, 1991, EDUC TRAIN MENT RET, V26, P190
Fickel K. M., 1998, J BEHAV ED, V8, P219, DOI 10.1023/A:1022887624824
Ganz JB, 2009, J AUTISM DEV DISORD, V39, P75, DOI 10.1007/s10803-008-0602-6
Gast D. L., 1991, ED TREATMENT CHILDRE, V14, P1
Gast D. L., 1990, EXCEPTIONALITY, V1, P81
Gast D. L., 2010, SINGLE SUBJECT RES M
Gursel O, 2006, EDUC TRAIN DEV DISAB, V41, P225
Hestenes LL, 2000, EARLY CHILD RES Q, V15, P229, DOI 10.1016/S0885-2006(00)00052-1
Holcombe A., 1994, J BEHAV ED, V4, P49, DOI 10.1007/BF01560509
Holcombe A., 1993, J BEHAV ED, V3, P259, DOI 10.1007/BF00961555
Horner RH, 2005, EXCEPT CHILDREN, V71, P165
Hoyson M., 1985, J DIVISION EARLY CHI, V8, P157
Kamps D., 1990, ED TREATMENT CHILDRE, V12, P197
Keel M. C., 2001, ED TREATMENT CHILDRE, V24, P46
KEEL MC, 1992, EXCEPT CHILDREN, V58, P357
Ledford JR, 2008, J AUTISM DEV DISORD, V38, P86, DOI 10.1007/s10803-007-0363-7
Lewis T. J., 1994, J BEHAV ED, V4, P267, DOI 10.1007/BF01531983
Magiera K., 2005, LEARNING DISABILITIE, V20, P79, DOI 10.1111/j.1540-5826.2005.00123.x
McCurdy B. L., 1990, ED TREATMENT CHILDRE, V13, P226
McDonnell J, 2006, EDUC TRAIN DEV DISAB, V41, P125
Mechling Linda C, 2008, Journal of Special Education Technology, V23
Mechling LC, 2007, J AUTISM DEV DISORD, V37, P1869, DOI 10.1007/s10803-007-0361-9
Michael J., 2007, APPL BEHAV ANAL, V2 nd, P374
Morse TE, 2004, EDUC TRAIN DEV DISAB, V39, P153
OLIVER PR, 1981, MENT RETARD, V19, P285
Palmer T, 1999, J DEV PHYS DISABIL, V11, P179, DOI 10.1023/A:1021851205489
Parker MA, 2002, EDUC TRAIN MENT RET, V37, P89
Parker RI, 2007, J SPEC EDUC, V40, P194, DOI 10.1177/00224669070400040101
Parker RI, 2009, EXCEPT CHILDREN, V75, P135
Parker RI, 2009, BEHAV THER, V40, P357, DOI 10.1016/j.beth.2008.10.006
Polloway E. A., 1986, REM SPEC EDUC, V7, P22
Reid D. H., 1984, J ASS SEVERELY HANDI, V9, P167
Riesen T., 2003, J BEHAV ED, V12, P241, DOI DOI 10.1023/A:1026076406656
Ross A. H., 2003, J BEHAV ED, V12, P287, DOI 10.1023/A:1025917824403
SCHOEN SF, 1995, J AUTISM DEV DISORD, V25, P503, DOI 10.1007/BF02178297
Schuster J. W., 1998, ED TREATMENT CHILDRE, V21, P28
Schuster J. W., 1992, J BEHAVIORAL ED, V2, P305, DOI 10.1007/BF00948820
Schuster J. W., 1996, J BEHAV ED, V6, P511, DOI 10.1007/BF02110520
Shelton B. S., 1991, LANG SPEECH HEAR SER, V22, P123
SINGLETON KC, 1995, EDUC TRAIN MENT RET, V30, P218
Smith T., 2001, FOCUS AUTISM OTHER D, V16, P86, DOI 10.1177/108835760101600204
Stahmer A. C., 2005, FOCUS AUTISM OTHER D, V20, P66, DOI DOI 10.1177/1088357
Sterling R. M., 1997, J BEHAV ED, V7, P151, DOI [10.1023/A:1022836907599, DOI 10.1023/A:1022836907599]
Stinson D. M., 1991, EXCEPTIONALITY, V2, P65
Strain P. S., 2001, FOCUS AUTISM OTHER D, V16, P120, DOI DOI 10.1177/108835760101600208
Venn M. L., 1996, FOCUS AUTISM OTHER D, V11, P15, DOI [10.1177/108835769601100103, DOI 10.1177/1088357696011]
Walker G, 2008, J AUTISM DEV DISORD, V38, P261, DOI 10.1007/s10803-007-0390-4
Werts M. G., 1993, EXCEPTIONALITY, V4, P81, DOI DOI 10.1207/S15327035EX0402_2
Werts MG, 2003, J SPEC EDUC, V37, P124
Whalen C, 1996, EDUC TRAIN MENT RET, V31, P188
WINTERLING V, 1990, J SPEC EDUC, V24, P101
Wolery M., 1993, J BEHAV ED, V3, P187, DOI 10.1007/BF00947035
WOLERY M, 1992, RES DEV DISABIL, V13, P239, DOI 10.1016/0891-4222(92)90028-5
Wolery M., 1992, TEACHING STUDENTS MO
Wolery M., 1993, EARLY EDUC DEV, V4, P20, DOI 10.1207/s15566935eed0401_2
WOLERY M, 1990, REM SPEC EDUC, V11, P47
WOLERY M, 1993, J LEARN DISABIL, V26, P642
Wolery M., 1992, ED TREATMENT CHILDRE, V15, P289
Wolery M, 2010, J SPEC EDUC, V44, P18, DOI 10.1177/0022466908328009
WOLERY M, 1991, EXCEPT CHILDREN, V57, P462
NR 84
TC 6
Z9 6
PU AMER ASSOC INTELLECTUAL DEVELOPMENTAL DISABILITIES
PI WASHINGTON
PA 444 N CAPITOL ST, NW STE 846, WASHINGTON, DC 20001-1512 USA
SN 1944-7515
J9 AJIDD-AM J INTELLECT
JI AJIDD-Am. J. Intellect. Dev. Disabil.
PD SEP
PY 2012
VL 117
IS 5
BP 413
EP 434
DI 10.1352/1944-7558-117.5.413
PG 22
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA 009NW
UT WOS:000309033500006
PM 22998488
ER
PT J
AU Wilkinson, KM
Light, J
Drager, K
AF Wilkinson, Krista M.
Light, Janice
Drager, Kathryn
TI Considerations for the Composition of Visual Scene Displays: Potential
Contributions of Information from Visual and Cognitive Sciences
SO AUGMENTATIVE AND ALTERNATIVE COMMUNICATION
LA English
DT Article
DE Aided AAC; Visual scene displays; Visual and cognitive sciences
ID AUTISM SPECTRUM DISORDER; SPEECH-LANGUAGE PATHOLOGISTS;
WILLIAMS-SYNDROME; AAC TECHNOLOGIES; JOINT ATTENTION; NATURAL SCENES;
AIDED AAC; DISABILITIES; CHILDREN; COMMUNICATION
AB Aided augmentative and alternative (AAC) interventions have been demonstrated to facilitate a variety of communication outcomes in persons with intellectual disabilities. Most aided AAC systems rely on a visual modality. When the medium for communication is visual, it seems likely that the effectiveness of intervention depends in part on the effectiveness and efficiency with which the information presented in the display can be perceived, identified, and extracted by communicators and their partners. Understanding of visual-cognitive processing - that is, how a user attends, perceives, and makes sense of the visual information on the display - therefore seems critical to designing effective aided AAC interventions. In this Forum Note, we discuss characteristics of one particular type of aided AAC display, that is, Visual Scene Displays (VSDs) as they may relate to user visual and cognitive processing. We consider three specific ways in which bodies of knowledge drawn from the visual cognitive sciences may be relevant to the composition of VSDs, with the understanding the direct research with children with complex communication needs is necessary to verify or refute our speculations.
C1 [Wilkinson, Krista M.; Light, Janice; Drager, Kathryn] Penn State Univ, University Pk, PA 16802 USA.
RP Wilkinson, KM (reprint author), Penn State Univ, 404-H Ford Bldg, University Pk, PA 16802 USA.
EM kmw22@psu.edu
FU Communication Enhancement Rehabilitation Engineering Research Center
(AAC_ RERC); National Institute on Disability and Rehabilitation
Research (NIDRR) [H133E030018]; National Institute of Child Health and
Human Development (NICHD) [P01 HD25995]
FX This research was supported in part through two grants: (1) the
Communication Enhancement Rehabilitation Engineering Research Center
(AAC_ RERC), a virtual research center that is funded by the National
Institute on Disability and Rehabilitation Research (NIDRR) under grant
H133E030018, and (2) grant # P01 HD25995 from the National Institute of
Child Health and Human Development (NICHD). The opinions contained in
this publication are those of the grantees and do not necessarily
reflect those of the granting agencies.
CR Barton A, 2006, AUGMENT ALTERN COMM, V22, P10, DOI 10.1080/07434610500238206
Biederman I., 1981, PERCEPTUAL ORG, P213
Blackstone S., 2005, AUGMENTATIVE COMMUNI, V1
BLOOMBERG K, 1990, J SPEECH HEAR RES, V33, P717
Bondy A, 2001, BEHAV MODIF, V25, P725, DOI 10.1177/0145445501255004
Bopp KD, 2004, AM J SPEECH-LANG PAT, V13, P5, DOI 10.1044/1058-0360(2004/003)
Bower T. G., 1977, PRIMER INFANT DEV
Bracco F, 2009, COGN PROCESS, V10, P41, DOI 10.1007/s10339-008-0246-7
Braun J, 2003, TRENDS COGN SCI, V7, P7, DOI 10.1016/S1364-6613(02)00008-6
Bruner J. S., 1983, CHILDS TALK LEARNING
Charman T, 2003, INT J LANG COMM DIS, V38, P265, DOI 10.1080/136820310000104830
Crouzet SM, 2010, J VISION, V10, DOI 10.1167/10.4.16
Culp D. M., 1986, AUGMENTATIVE ALTERNA, V2, P19, DOI 10.1080/07434618612331273830
Dietz A., 2006, AM SPEECH LANG HEAR
Drager KDR, 2003, J SPEECH LANG HEAR R, V46, P298, DOI 10.1044/1092-4388(2003/024)
Drager KDR, 2004, J SPEECH LANG HEAR R, V47, P1133, DOI 10.1044/1092-4388(2004/084)
Fei-Fei L., 2005, VIS COGN, V12, P893, DOI [10.1080/13506280444000571, DOI 10.1080/13506280444000571]
Fletcher-Watson S, 2009, NEUROPSYCHOLOGIA, V47, P248, DOI 10.1016/j.neuropsychologia.2008.07.016
Fletcher-Watson S, 2008, PERCEPTION, V37, P571, DOI 10.1068/p5705
Fuller D., 1997, AUGMENTATIVE ALTERNA, V13, P30, DOI 10.1080/07434619712331277818
Fuller DR, 1987, AUGMENTATIVE ALTERNA, V3, P26, DOI 10.1080/07434618712331274219
Gliga T, 2009, INFANCY, V14, P550, DOI 10.1080/15250000903144199
Harris MD, 2004, AM J SPEECH-LANG PAT, V13, P155, DOI 10.1044/1058-0360(2004/016)
Higginbotham D. J., 1995, AUGMENTATIVE ALTERNA, V11, P2, DOI 10.1080/07434619512331277079
Hopkins K. A., 1980, AUSTR J EARLY CHILDH, V5, P25
HURLBUT BI, 1982, J APPL BEHAV ANAL, V15, P241, DOI 10.1901/jaba.1982.15-241
Iacono T., 2009, AUTISM SPECTRUM DISO
Jagaroo V, 2008, AUGMENT ALTERN COMM, V24, P29, DOI 10.1080/07434610701390673
Johnson JM, 2006, AUGMENT ALTERN COMM, V22, P85, DOI 10.1080/07434610500483588
Johnston SS, 1993, LANG SPEECH HEAR SER, V24, P225
Joseph RM, 2009, DEVELOPMENTAL SCI, V12, P1083, DOI 10.1111/j.1467-7687.2009.00855.x
Kayser C, 2004, CURR OPIN NEUROBIOL, V14, P468, DOI 10.1016/j.conb.2004.06.002
Klin A, 2002, ARCH GEN PSYCHIAT, V59, P809, DOI 10.1001/archpsyc.59.9.809
Langton SRH, 2000, TRENDS COGN SCI, V4, P50, DOI 10.1016/S1364-6613(99)01436-9
Light J., 2004, AUGMENTATIVE ALTERNA, V20, P63, DOI 10.1080/07434610410001655553
Light J., 2008, SEM ANN C INT SOC AU
Light J., 1991, AUGMENTATIVE ALTERNA, V7, P186, DOI 10.1080/07434619112331275893
Light J., 2010, MIN ANN C AM SPEECH
Liss M, 2006, AUTISM, V10, P155, DOI 10.1177/1362361306062021
Mack S. C., 2011, J VISION, V9, P1
Mann TA, 2003, J CHILD PSYCHOL PSYC, V44, P274, DOI 10.1111/1469-7610.00120
McKelvey ML, 2010, AM J SPEECH-LANG PAT, V19, P22, DOI 10.1044/1058-0360(2009/08-0021)
MIRENDA P, 1989, J SPEECH HEAR DISORD, V54, P131
MIZUKO M, 1989, J SPEECH HEAR DISORD, V54, P627
Mizuko M., 1994, AUGMENTATIVE ALTERNA, V10, P237, DOI 10.1080/07434619412331276940
Nelson K., 1986, EVENT KNOWLEDGE STRU
New J, 2007, P NATL ACAD SCI USA, V104, P16598, DOI 10.1073/pnas.0703913104
Oliva A, 2007, TRENDS COGN SCI, V11, P520, DOI 10.1016/j.tics.2007.09.009
Peelen MV, 2009, NATURE, V460, P94, DOI 10.1038/nature08103
Pelphrey K. A., 2002, J AUTISM DEV DISORD, V32, P49
Plaisted K, 1998, J CHILD PSYCHOL PSYC, V39, P765, DOI 10.1017/S0021963098002601
Plaisted K, 1999, J CHILD PSYCHOL PSYC, V40, P733, DOI 10.1111/1469-7610.00489
Rensink RA, 1997, PSYCHOL SCI, V8, P368, DOI 10.1111/j.1467-9280.1997.tb00427.x
Riby D, 2009, J INTELL DISABIL RES, V53, P169, DOI 10.1111/j.1365-2788.2008.01142.x
Riby DM, 2008, NEUROPSYCHOLOGIA, V46, P2855, DOI 10.1016/j.neuropsychologia.2008.05.003
Romski M. A., 1996, BREAKING SPEECH BARR
Smilek D, 2006, BRAIN RES, V1080, P101, DOI 10.1016/j.brainres.2005.12.090
Sullivan M, 2007, J AUTISM DEV DISORD, V37, P37, DOI 10.1007/s10803-006-0335-3
Toth K, 2006, J AUTISM DEV DISORD, V36, P993, DOI 10.1007/s10803-006-0137-7
VENTURINO M, 1992, PERCEPT PSYCHOPHYS, V52, P425, DOI 10.3758/BF03206702
Warreyn P, 2007, J AUTISM DEV DISORD, V37, P501, DOI 10.1007/s10803-006-0184-0
Watt N, 2006, J SPEECH LANG HEAR R, V49, P1224, DOI 10.1044/1092-4388(2006/088)
Wetherby A, 2006, SOCIAL COMMUNICATION, P3
Wetherby A., 1993, COMMUNICATION SYMBOL
WILHELM H, 1976, AM J MENT DEF, V81, P26
Wilkinson K. M., 2004, AUGMENTATIVE ALTERNA, V20, P123, DOI 10.1080/07434610410001699717
Wilkinson KM, 2011, J SPEECH LANG HEAR R, V54, P1644, DOI 10.1044/1092-4388(2011/10-0098)
Wilkinson KM, 2007, MENT RETARD DEV D R, V13, P58, DOI 10.1002/mrdd.20133
Yoder P. J., 2006, SOCIAL COMMUNICATION, P117
Phillips B, 1993, Assist Technol, V5, P36
NR 70
TC 19
Z9 19
PU INFORMA HEALTHCARE
PI LONDON
PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND
SN 0743-4618
J9 AUGMENT ALTERN COMM
JI Augment. Altern. Commun.
PD SEP
PY 2012
VL 28
IS 3
BP 137
EP 147
DI 10.3109/07434618.2012.704522
PG 11
WC Audiology & Speech-Language Pathology; Rehabilitation
SC Audiology & Speech-Language Pathology; Rehabilitation
GA 000TX
UT WOS:000308412800001
PM 22946989
ER
PT J
AU Falcomata, TS
Roane, HS
Muething, CS
Stephenson, KM
Ing, AD
AF Falcomata, Terry S.
Roane, Henry S.
Muething, Colin S.
Stephenson, Kasey M.
Ing, Anna D.
TI Functional Communication Training and Chained Schedules of Reinforcement
to Treat Challenging Behavior Maintained by Terminations of Activity
Interruptions
SO BEHAVIOR MODIFICATION
LA English
DT Article
DE aggression; Asperger syndrome; autism; chained schedule of
reinforcement; challenging behavior; functional communication training
ID COMBINED-ANTECEDENT VARIABLES; DESTRUCTIVE BEHAVIOR; PREFERENCE;
REQUESTS; CHILDREN; AUTISM; DONT
AB In this article, the authors evaluated functional communication training (FCT) and a chained schedule of reinforcement for the treatment of challenging behavior exhibited by two individuals diagnosed with Asperger syndrome and autism, respectively. Following a functional analysis with undifferentiated results, the authors demonstrated that challenging behavior was occasioned by interruptions of ongoing activities and maintained by terminations of interruptions. Next, they demonstrated the effectiveness of a treatment 1consisting of FCT with a chained schedule of reinforcement. Last, they modified the chained schedule procedure to increase ease of implementation and promote toleration of activity interruptions, and academic tasks were incorporated into the treatment.
C1 [Falcomata, Terry S.; Muething, Colin S.] Univ Texas Austin, Dept Educ Psychol, Austin, TX 78712 USA.
[Roane, Henry S.] SUNY Upstate Med Univ, Syracuse, NY USA.
[Stephenson, Kasey M.] Munroe Meyer Inst, Ctr Autism Spectrum Disorders, Omaha, NE USA.
[Ing, Anna D.] Univ Iowa, Dept Sch Psychol, Iowa City, IA USA.
RP Falcomata, TS (reprint author), Univ Texas Austin, Dept Educ Psychol, 1 Univ Stn D5300, Austin, TX 78712 USA.
EM falcomata@austin.utexas.edu
CR Adelinis JD, 1999, J APPL BEHAV ANAL, V32, P519, DOI 10.1901/jaba.1999.32-519
Bowman LG, 1997, J APPL BEHAV ANAL, V30, P251, DOI 10.1901/jaba.1997.30-251
Call NA, 2005, J APPL BEHAV ANAL, V38, P385, DOI 10.1901/jaba.2005.51-04
CARR EG, 1985, J APPL BEHAV ANAL, V18, P111, DOI 10.1901/jaba.1985.18-111
Dolezal DN, 2010, J APPL BEHAV ANAL, V43, P309, DOI 10.1901/jaba.2010.43-309
Ferster C.B., 1957, SCHEDULES REINFORCEM
FISHER W, 1993, J APPL BEHAV ANAL, V26, P23, DOI 10.1901/jaba.1993.26-23
Fisher WW, 2000, BEHAV MODIF, V24, P3, DOI 10.1177/0145445500241001
Fisher WW, 1996, J APPL BEHAV ANAL, V29, P117, DOI 10.1901/jaba.1996.29-117
Fisher WW, 1998, J APPL BEHAV ANAL, V31, P339, DOI 10.1901/jaba.1998.31-339
Gollub L., 1977, HDB OPERANT BEHAV, P288
Hagopian LP, 2007, J APPL BEHAV ANAL, V40, P89, DOI 10.1901/jaba.2007.63-05
Hanley GP, 2001, J APPL BEHAV ANAL, V34, P17, DOI 10.1901/jaba.2001.34-17
Hanley GP, 2007, J APPL BEHAV ANAL, V40, P277, DOI 10.1901/jaba.2007.57-06
Hanley GP, 1997, J APPL BEHAV ANAL, V30, P459, DOI 10.1901/jaba.1997.30-459
IWATA BA, 1994, J APPL BEHAV ANAL, V27, P197, DOI 10.1901/jaba.1994.27-197
Kuhn DE, 2010, J APPL BEHAV ANAL, V43, P249, DOI 10.1901/jaba.2010.43-249
Luczynski KC, 2009, J APPL BEHAV ANAL, V42, P511, DOI 10.1901/jaba.2009.42-511
Luczynski KC, 2010, J APPL BEHAV ANAL, V43, P397, DOI 10.1901/jaba.2010.43-397
MACE FC, 1994, J APPL BEHAV ANAL, V27, P385, DOI 10.1901/jaba.1994.27-385
Myers SM, 2007, PEDIATRICS, V120, P1162, DOI 10.1542/peds.2007-2362
O'Reilly MF, 2000, J APPL BEHAV ANAL, V33, P511, DOI 10.1901/jaba.2000.33-511
Roane HS, 1998, J APPL BEHAV ANAL, V31, P605, DOI 10.1901/jaba.1998.31-605
Sigafoos J, 1996, BEHAV MODIF, V20, P60, DOI 10.1177/01454455960201003
Tiger Jeffrey H, 2008, Behav Anal Pract, V1, P16
Tiger JH, 2006, J APPL BEHAV ANAL, V39, P475, DOI 10.1901/jaba.2006.48-06
Van Camp CM, 2000, J APPL BEHAV ANAL, V33, P207, DOI 10.1901/jaba.2000.33-207
WACKER D, 1990, J APPL BEHAV ANAL, V23, P333, DOI 10.1901/jaba.1990.23-333
Wacker D. P., 2005, ED PSYCHOL, V25, P233, DOI [10. 1080/0144341042000301184, DOI 10.1080/0144341042000301184]
Wacker DP, 1996, J APPL BEHAV ANAL, V29, P79, DOI 10.1901/jaba.1996.29-79
NR 30
TC 4
Z9 4
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0145-4455
J9 BEHAV MODIF
JI Behav. Modificat.
PD SEP
PY 2012
VL 36
IS 5
BP 630
EP 649
DI 10.1177/0145445511433821
PG 20
WC Psychology, Clinical
SC Psychology
GA 005QT
UT WOS:000308765600002
PM 22327267
ER
PT J
AU Ducharme, JM
Ng, O
AF Ducharme, Joseph M.
Ng, Olivia
TI Errorless Academic Compliance Training: A School-Based Application for
Young Students With Autism
SO BEHAVIOR MODIFICATION
LA English
DT Article
DE autism; teacher training; noncompliance; errorless approaches
ID PARENTAL REQUESTS; CHILDREN; BEHAVIOR; INTERVENTION; DISCRIMINATION;
DISORDERS; CLASSROOM
AB Errorless academic compliance training is a graduated, noncoercive approach to treating oppositional behavior in children. In the present study, three teaching staff in a special education classroom were trained to conduct this intervention with three male students diagnosed with autism spectrum disorders. During baseline, staff delivered a range of academic and other classroom requests and recorded student compliance. A hierarchy of compliance probabilities was then calculated, ranging from Level 1 (requests yielding high levels of compliance) to Level 4 (those typically yielding noncompliance). At treatment initiation, teaching staff delivered high densities of Level 1 requests and provided reinforcement for compliance. Subsequent request levels were faded in over time, at a slow enough rate to ensure continued high compliance. By intervention end, all three students demonstrated substantially improved compliance to classroom requests that had commonly yielded noncompliance before intervention. Covariant improvement in on-task skills was also evident.
C1 [Ducharme, Joseph M.; Ng, Olivia] Univ Toronto, Ontario Inst Studies Educ, Dept Human Dev & Appl Psychol, Toronto, ON M5S 1V6, Canada.
RP Ducharme, JM (reprint author), Univ Toronto, Ontario Inst Studies Educ, Dept Human Dev & Appl Psychol, 252 Bloor St W, Toronto, ON M5S 1V6, Canada.
EM joe.ducharme@utoronto.ca
CR ARBELLE S, 1994, J AUTISM DEV DISORD, V24, P693, DOI 10.1007/BF02172280
Barkley R. A., 1998, YOUR DEFIANT CHILD 8
Barlow D. H., 1984, SINGLE CASE EXPT DES
Barnett DW, 1996, SCHOOL PSYCHOL QUART, V11, P95, DOI 10.1037/h0088923
CARR EG, 1991, J APPL BEHAV ANAL, V24, P523, DOI 10.1901/jaba.1991.24-523
Ducharme J. M., 2007, HDB PARENT TRAINING, P268
Ducharme J. M., 2010, CLIN CASE STUDIES, V9, P167, DOI [10.1177/1534650110370714, DOI 10.1177/1534650110370714]
Ducharme JM, 2007, BEHAV MODIF, V31, P329, DOI 10.1177/0145445506295050
Ducharme JM, 2005, SCHOOL PSYCHOL REV, V34, P107
Ducharme JM, 2001, CHILD ABUSE NEGLECT, V25, P855, DOI 10.1016/S0145-2134(01)00243-5
Ducharme JM, 2011, SCHOOL PSYCHOL REV, V40, P257
DUCHARME JM, 1993, BEHAV THER, V24, P209, DOI 10.1016/S0005-7894(05)80264-3
Ducharme JM, 2008, BEHAV MODIF, V32, P39, DOI 10.1177/0145445507303845
Ducharme JM, 2005, BEHAV THER, V36, P213, DOI 10.1016/S0005-7894(05)80070-X
Ducharme JM, 2002, AM J ORTHOPSYCHIAT, V72, P585, DOI 10.1037//0002-9432.72.4.585
Ducharme JM, 2004, J AM ACAD CHILD PSY, V43, P163, DOI 10.1097/01.chi.0000101370.03068.87
Farmer CA, 2011, RES AUTISM SPECT DIS, V5, P317, DOI 10.1016/j.rasd.2010.04.014
Fombonne E, 2009, PEDIATR RES, V65, P591, DOI 10.1203/PDR.0b013e31819e7203
Gilchrist R. H., 2006, TREATMENT CHILDHOOD, P411
Houlihan D., 1991, BEHAV RESIDENTIAL TR, V6, P321, DOI 10.1002/bin.2360060503
Koegel LK, 2010, J AUTISM DEV DISORD, V40, P1057, DOI 10.1007/s10803-010-0962-6
Lalli JS, 1995, J APPL BEHAV ANAL, V28, P551, DOI 10.1901/jaba.1995.28-551
Love JR, 2009, RES AUTISM SPECT DIS, V3, P421, DOI 10.1016/j.rasd.2008.08.008
McMahon R. J., 2003, HELPING NONCOMPLIANT
PACE GM, 1994, J APPL BEHAV ANAL, V27, P301, DOI 10.1901/jaba.1994.27-301
PARRISH JM, 1986, J APPL BEHAV ANAL, V19, P241, DOI 10.1901/jaba.1986.19-241
Sigmund E., 2009, J CLIN CHILD ADOLESC, V38, P439
Soutor T. A., 1994, BEHAV INTERVENT, V9, P141, DOI 10.1002/bin.2360090302
TERRACE HS, 1963, J EXP ANAL BEHAV, V6, P1, DOI 10.1901/jeab.1963.6-1
Thomson K, 2009, RES AUTISM SPECT DIS, V3, P590, DOI 10.1016/j.rasd.2009.01.003
TOUCHETT.PE, 1968, J EXP ANAL BEHAV, V11, P39, DOI 10.1901/jeab.1968.11-39
VOLLMER TR, 1992, RES DEV DISABIL, V13, P393, DOI 10.1016/0891-4222(92)90013-V
NR 32
TC 1
Z9 1
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0145-4455
J9 BEHAV MODIF
JI Behav. Modificat.
PD SEP
PY 2012
VL 36
IS 5
BP 650
EP 669
DI 10.1177/0145445511436006
PG 20
WC Psychology, Clinical
SC Psychology
GA 005QT
UT WOS:000308765600003
PM 22421393
ER
PT J
AU Andrews, N
AF Andrews, Nick
TI Epidemiological designs for vaccine safety assessment: Methods and
pitfalls
SO BIOLOGICALS
LA English
DT Article; Proceedings Paper
CT Symposium on Post Licensure Evaluation of Vaccine Safety - Current
Status and Future Directions
CY APR 27-28, 2011
CL Barcelona, SPAIN
SP Int Alliance Biol Standardizat (IABS)
DE Vaccine safety; Case control; Cohort; Self-controlled case series;
Post-licensure; Methodology
ID CASE SERIES; CAUSAL ASSOCIATION; AUTISM; MEASLES; MUMPS; MMR
AB Three commonly used designs for vaccine safety assessment post licensure are cohort, case-control and self-controlled case series. These methods are often used with routine health databases and immunisation registries. This paper considers the issues that may arise when designing an epidemiological study, such as understanding the vaccine safety question, case definition and finding, limitations of data sources, uncontrolled confounding, and pitfalls that apply to the individual designs. The example of MMR and autism, where all three designs have been used, is presented to help consider these issues. (C) 2011 The International Alliance for Biological Standardization. Published by Elsevier Ltd. All rights reserved.
C1 Hlth Protect Agcy, Stat Modelling & Econ Dept, Hlth Protect Serv, London NW9 5EQ, England.
RP Andrews, N (reprint author), Hlth Protect Agcy, Stat Modelling & Econ Dept, Hlth Protect Serv, 61 Colindale Ave, London NW9 5EQ, England.
EM nick.andrews@hpa.org.uk
CR Andrews N, 2001, EUR J EPIDEMIOL, V17, P701, DOI 10.1023/A:1015691619745
Bonhoeffer J, 2002, VACCINE, V21, P298, DOI 10.1016/S0264-410X(02)00449-8
Farrington CP, 1998, AM J EPIDEMIOL, V147, P93
Farrington CP, 2004, VACCINE, V22, P2064, DOI 10.1016/j.vaccine.2004.01.017
Farrington CP, 2001, VACCINE, V19, P3632, DOI 10.1016/S0264-410X(01)00097-4
Farrington CP, 2009, BIOSTATISTICS, V10, P3, DOI 10.1093/biostatistics/kxn013
FARRINGTON CP, 1995, BIOMETRICS, V51, P228, DOI 10.2307/2533328
FINE PEM, 1992, AM J EPIDEMIOL, V136, P121
Glanz JM, 2006, J CLIN EPIDEMIOL, V59, P808, DOI 10.1016/j.jclinepi.2005.11.012
Madsen KM, 2002, NEW ENGL J MED, V347, P1477, DOI 10.1056/NEJMoa021134
Rodrigues LC, 1999, EPIDEMIOL REV, V21, P56
Smeeth L, 2006, FAM PRACT, V23, P597, DOI 10.1093/fampra/cml025
Smeeth L, 2004, LANCET, V364, P963, DOI 10.1016/S0140-6736(04)17020-7
Taylor B, 1999, LANCET, V353, P2026, DOI 10.1016/S0140-6736(99)01239-8
Whitaker HJ, 2009, STAT METHODS MED RES, V18, P7, DOI 10.1177/0962280208092342
NR 15
TC 2
Z9 2
PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 1045-1056
J9 BIOLOGICALS
JI Biologicals
PD SEP
PY 2012
VL 40
IS 5
BP 389
EP 392
DI 10.1016/j.biologicals.2011.08.010
PG 4
WC Biochemical Research Methods; Biotechnology & Applied Microbiology;
Pharmacology & Pharmacy
SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology;
Pharmacology & Pharmacy
GA 010IB
UT WOS:000309087000011
PM 21985898
ER
PT J
AU Webb, SA
AF Webb, Sarah A.
TI Unraveling autism one de novo mutation at a time
SO BIOTECHNIQUES
LA English
DT News Item
ID SPECTRUM
CR Iossifov I, 2012, NEURON, V74, P285, DOI 10.1016/j.neuron.2012.04.009
Kong A, 2012, NATURE, V488, P471, DOI 10.1038/nature11396
Neale BM, 2012, NATURE, V485, P242, DOI 10.1038/nature11011
O'Roak BJ, 2012, NATURE, V485, P246, DOI 10.1038/nature10989
Sanders SJ, 2012, NATURE, V485, P237, DOI 10.1038/nature10945
Sebat J, 2007, SCIENCE, V316, P445, DOI 10.1126/science.1138659
NR 6
TC 0
Z9 0
PU BIOTECHNIQUES OFFICE
PI NEW YORK
PA 52 VANDERBILT AVE, NEW YORK, NY 10017 USA
SN 0736-6205
J9 BIOTECHNIQUES
JI Biotechniques
PD SEP
PY 2012
VL 53
IS 3
BP 133
EP +
DI 10.2144/000113920
PG 3
WC Biochemical Research Methods; Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA 008RW
UT WOS:000308975200005
PM 22963474
ER
PT J
AU Eijkelkamp, N
Linley, JE
Baker, MD
Minett, MS
Cregg, R
Werdehausen, R
Rugiero, F
Wood, JN
AF Eijkelkamp, Niels
Linley, John E.
Baker, Mark D.
Minett, Michael S.
Cregg, Roman
Werdehausen, Robert
Rugiero, Francois
Wood, John N.
TI Neurological perspectives on voltage-gated sodium channels
SO BRAIN
LA English
DT Review
DE ion channel; genetics; pain; epilepsy; SCN1A
ID EXTREME PAIN DISORDER; SEVERE MYOCLONIC EPILEPSY; SPINAL SENSORY
NEURONS; PERSISTENT NA+ CURRENT; ROOT GANGLION NEURONS; FEBRILE
SEIZURES-PLUS; DE-NOVO MUTATIONS; FAMILIAL HEMIPLEGIC MIGRAINE;
NEONATAL-INFANTILE SEIZURES; CEREBELLAR PURKINJE NEURONS
AB The activity of voltage-gated sodium channels has long been linked to disorders of neuronal excitability such as epilepsy and chronic pain. Recent genetic studies have now expanded the role of sodium channels in health and disease, to include autism, migraine, multiple sclerosis, cancer as well as muscle and immune system disorders. Transgenic mouse models have proved useful in understanding the physiological role of individual sodium channels, and there has been significant progress in the development of subtype selective inhibitors of sodium channels. This review will outline the functions and roles of specific sodium channels in electrical signalling and disease, focusing on neurological aspects. We also discuss recent advances in the development of selective sodium channel inhibitors.
C1 [Eijkelkamp, Niels; Linley, John E.; Minett, Michael S.; Cregg, Roman; Werdehausen, Robert; Rugiero, Francois; Wood, John N.] UCL, Wolfson Inst Biomed Res, Mol Nocicept Grp, London WC1E 6BT, England.
[Baker, Mark D.] Neurosci Inst Cell & Mol Sci Barts & London Sch M, London E1 2AT, England.
[Werdehausen, Robert] Univ Dusseldorf, Fac Med, Dept Anaesthesiol, D-40225 Dusseldorf, Germany.
RP Wood, JN (reprint author), UCL, Wolfson Inst Biomed Res, Mol Nocicept Grp, Gower St,Cruciform Bldg, London WC1E 6BT, England.
EM n.eijkelkamp@ucl.ac.uk; j.wood@ucl.ac.uk
FU Medical Research Council; Wellcome Trust; Biochemistry and Biotechnology
Research Council; Netherlands Organisation for Scientific Research
(NWO); Deutsche Forschungsgemeinschaft, Bonn, Germany [We 4860/1-1]
FX J.N.W. thanks the Medical Research Council, The Wellcome Trust and the
Biochemistry and Biotechnology Research Council for generous financial
support. N.E. is supported by a Rubicon fellowship of The Netherlands
Organisation for Scientific Research (NWO). R.W. is supported by a
research fellowship (We 4860/1-1) from Deutsche Forschungsgemeinschaft,
Bonn, Germany.
CR Abrahamsen B, 2008, SCIENCE, V321, P702, DOI 10.1126/science.1156916
Ahmad S, 2007, HUM MOL GENET, V16, P2114, DOI 10.1093/hmg/ddm160
Akopian AN, 1996, NATURE, V379, P257, DOI 10.1038/379257a0
Akopian AN, 1999, NAT NEUROSCI, V2, P541
Alabi AA, 2007, NATURE, V450, P370, DOI 10.1038/nature06266
ALZHEIMER C, 1993, J NEUROSCI, V13, P660
Amaya F, 2006, J NEUROSCI, V26, P12852, DOI 10.1523/JNEUROSCI.4015-06.2006
Armstrong CM, 2006, P NATL ACAD SCI USA, V103, P17991, DOI 10.1073/pnas.0607603103
Armstrong CM, 1998, NEURON, V20, P371, DOI 10.1016/S0896-6273(00)80981-2
Aurlien D, 2009, SEIZURE-EUR J EPILEP, V18, P158, DOI 10.1016/j.seizure.2008.07.008
Baker MD, 2005, J PHYSIOL-LONDON, V567, P851, DOI 10.1113/jphysiol.2005.089771
Baker MD, 2003, J PHYSIOL-LONDON, V548, P373, DOI 10.1113/jphysiol.2003.039131
Baker MD, 2000, BRIT J PHARMACOL, V129, P1617, DOI 10.1038/sj.bjp.0703261
Baker MD, 1997, J NEUROPHYSIOL, V77, P1503
Bant JS, 2010, P NATL ACAD SCI USA, V107, P12357, DOI 10.1073/pnas.1005633107
Baroudi G, 2002, CIRC RES, V90, pE11, DOI 10.1161/hh0102.102977
Baroudi G, 2001, CIRC RES, V88, pE78, DOI 10.1161/hh1201.093270
Ben-Menachem E, 2007, EPILEPSIA, V48
BENNETT PB, 1995, NATURE, V376, P683, DOI 10.1038/376683a0
Beyreuther B, 2006, EUR J PHARMACOL, V539, P64, DOI 10.1016/j.ejphar.2006.04.009
Beyreuther BK, 2007, CNS DRUG REV, V13, P21, DOI 10.1111/j.1527-3458.2007.00001.x
Beyreuther BK, 2007, EUR J PHARMACOL, V565, P98, DOI 10.1016/j.ejphar.2007.02.041
Bezzina CR, 2003, CIRC RES, V92, P159, DOI 10.1161/01.RES.0000052672.97759.36
Binshtok AM, 2009, ANESTHESIOLOGY, V111, P127, DOI 10.1097/ALN.0b013e3181a915e7
Binshtok AM, 2007, NATURE, V449, P607, DOI 10.1038/nature06191
Biswas S, 2008, J GEN PHYSIOL, V131, P197, DOI 10.1085/jgp.200709863
Biton V, 2007, CLIN NEUROPHARMACOL, V30, P230, DOI 10.1097/01.WNF.0B013E3180413D7D
Black JA, 1996, MOL BRAIN RES, V43, P117, DOI 10.1016/S0169-328X(96)00163-5
Black JA, 2008, J NEUROL SCI, V274, P57, DOI 10.1016/j.jns.2008.04.001
Black JA, 2002, EXP EYE RES, V75, P193, DOI 10.1006/exer.2002.2014
Black JA, 2002, MOL BRAIN RES, V105, P19, DOI 10.1016/S0169-328X(02)00385-6
BOHLE T, 1995, BIOPHYS J, V68, P121
Boiko T, 2001, NEURON, V30, P91, DOI 10.1016/S0896-6273(01)00265-3
Bölcskei Hedvig, 2009, Recent Pat CNS Drug Discov, V4, P14
Bosmans F, 2008, NATURE, V456, P202, DOI 10.1038/nature07473
Brackenbury WJ, 2011, FRONT PHARMACOL, V2, DOI 10.3389/fphar.2011.00053
Brackenbury WJ, 2010, P NATL ACAD SCI USA, V107, P2283, DOI 10.1073/pnas.0909434107
Brittain JM, 2011, NAT MED, V17, P822, DOI 10.1038/nm.2345
Brochu RM, 2006, MOL PHARMACOL, V69, P823, DOI 10.1124/mol.105.018127
Bromley RL, 2009, CURR OPIN NEUROL, V22, P162, DOI 10.1097/WCO.0b013e3283292401
Burge JA, 2012, CURR NEUROL NEUROSCI, V12, P62, DOI 10.1007/s11910-011-0238-3
Calabresi P, 2007, TRENDS PHARMACOL SCI, V28, P188, DOI 10.1016/j.tips.2007.02.005
Caldwell JH, 2000, P NATL ACAD SCI USA, V97, P5616, DOI 10.1073/pnas.090034797
CAMPBELL RWF, 1987, NEW ENGL J MED, V316, P29
Cannon SC, 2010, J CLIN INVEST, V120, P80, DOI 10.1172/JCI41340
Cardenas DD, 2002, PAIN, V96, P365, DOI 10.1016/S0304-3959(01)00483-3
Carranza Rojo D, 2011, NEUROLOGY, V77, P380
Carrithers MD, 2009, J BIOL CHEM, V284, P8114, DOI 10.1074/jbc.M801892200
Carrithers MD, 2007, J IMMUNOL, V178, P7822
Carter AJ, 1998, AMINO ACIDS, V14, P159, DOI 10.1007/BF01345257
Cattaneo A, 2010, CURR OPIN MOL THER, V12, P94
Catterall WA, 2005, PHARMACOL REV, V57, P397, DOI 10.1124/pr.57.4.4
Catterall WA, 2000, NEURON, V26, P13, DOI 10.1016/S0896-6273(00)81133-2
Catterall WA, 2007, TOXICON, V49, P124, DOI 10.1016/j.toxicon.2006.09.022
Catterall WA, 2010, J PHYSIOL-LONDON, V588, P1849, DOI 10.1113/jphysiol.2010.187484
Cestele S, 2008, J NEUROSCI, V28, P7273, DOI 10.1523/JNEUROSCI.4453-07.2008
Challapalli V, 2005, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD003345.pub2
Chambers JC, 2010, NAT GENET, V42, P149, DOI 10.1038/ng.516
Chen CL, 2002, P NATL ACAD SCI USA, V99, P17072, DOI 10.1073/pnas.212638099
Chen QY, 1998, NATURE, V392, P293
Cheung HMC, 2011, CAN J ANESTH, V58, P443, DOI 10.1007/s12630-011-9479-5
Chioni AM, 2005, J NEUROSCI METH, V147, P88, DOI 10.1016/j.jneumeth.2005.03.010
Choi JS, 2009, EXP NEUROL, V216, P383, DOI 10.1016/j.expneurol.2008.12.012
Chong MS, 2003, CLIN J PAIN, V19, P59, DOI 10.1097/00002508-200301000-00008
Clare JJ, 2010, EXPERT OPIN INV DRUG, V19, P45, DOI 10.1517/13543780903435340
Conway D, 2010, CURR NEUROL NEUROSCI, V10, P381, DOI 10.1007/s11910-010-0125-3
Corry B, 2012, J AM CHEM SOC, V134, P1840, DOI 10.1021/ja210020h
Cossette P, 2003, EPILEPSY RES, V53, P107, DOI 10.1016/S0920-1211(02)00259-0
Cox JJ, 2006, NATURE, V444, P894, DOI 10.1038/nature05413
Cox JJ, 2010, HUM MUTAT, V31, pE1670, DOI 10.1002/humu.21325
Craner MJ, 2005, GLIA, V49, P220, DOI 10.1002/glia.20112
Craner MJ, 2004, BRAIN, V127, P294, DOI 10.1093/brain/awh032
Cummins TR, 2007, PAIN, V131, P243, DOI 10.1016/j.pain.2007.07.026
Cummins TR, 2005, FEBS LETT, V579, P2166, DOI 10.1016/j.febslet.2005.03.009
Curia G, 2004, NEUROSCIENCE, V127, P63, DOI 10.1016/j.neuroscience.2004.04.040
De Jonghe P, 2011, DEV MED CHILD NEUROL, V53, P7, DOI 10.1111/j.1469-8749.2011.03965.x
DEVOR M, 1992, PAIN, V48, P261, DOI 10.1016/0304-3959(92)90067-L
Dib-Hajj S, 2002, TRENDS NEUROSCI, V25, P253, DOI 10.1016/S0166-2236(02)02150-1
Dib-Hajj SD, 2008, MOL PAIN, V4, DOI 10.1186/1744-8069-4-37
Dib-Hajj SD, 2007, TRENDS NEUROSCI, V30, P555, DOI 10.1016/j.tins.2007.08.004
Dib-Hajj SD, 1998, P NATL ACAD SCI USA, V95, P8963, DOI 10.1073/pnas.95.15.8963
Dib-Hajj SD, 2010, ANNU REV NEUROSCI, V33, P325, DOI 10.1146/annurev-neuro-060909-153234
Dib-Hajj SD, 1999, PAIN, V83, P591, DOI 10.1016/S0304-3959(99)00169-4
Dichgans M, 2005, LANCET, V366, P371, DOI 10.1016/S0140-6736(05)66786-4
Diss JKJ, 2004, EUR BIOPHYS J BIOPHY, V33, P180, DOI 10.1007/s00249-004-0389-0
Dong XW, 2007, NEUROSCIENCE, V146, P812, DOI 10.1016/j.neuroscience.2007.01.054
Doty P, 2007, NEUROTHERAPEUTICS, V4, P145, DOI 10.1016/j.nurt.2006.10.002
DREIFUSS FE, 1983, EPILEPSIA, V24, pS45, DOI 10.1111/j.1528-1157.1983.tb04642.x
Drizin I, 2008, BIOORGAN MED CHEM, V16, P6379, DOI 10.1016/j.bmc.2008.05.003
Durham D, 1999, Crit Care Resusc, V1, P344
Ebell MH, 2006, AM FAM PHYSICIAN, V74, P79
Ekberg J, 2006, P NATL ACAD SCI USA, V103, P17030, DOI 10.1073/pnas.0601819103
Ernst SJ, 2009, ENDOCRINOLOGY, V150, P1132, DOI 10.1210/en.2008-0991
Errington AC, 2008, MOL PHARMACOL, V73, P157, DOI 10.1124/mol.107.039867
Escayg A, 2000, NAT GENET, V24, P343
Estacion M, 2010, EXP NEUROL, V224, P362, DOI 10.1016/j.expneurol.2010.04.012
Fang X, 2002, J NEUROSCI, V22, P7425
Fertleman CR, 2006, NEURON, V52, P767, DOI 10.1016/j.neuron.2006.10.006
Fertleman CR, 2007, NEUROLOGY, V69, P586, DOI 10.1212/01.wnl.0000268065.16865.5f
Fink DJ, 2011, ANN NEUROL, V70, P207, DOI 10.1002/ana.22446
Fischer J, 2002, ARZNEIMITTEL-FORSCH, V52, P256
Fischer TZ, 2009, ANN NEUROL, V65, P733, DOI 10.1002/ana.21678
Fletcher EV, 2011, J BIOL CHEM, V286, P36700, DOI 10.1074/jbc.M111.250225
Fraser SP, 2005, CLIN CANCER RES, V11, P5381, DOI 10.1158/1078-0432.CCR-05-0327
Fraser SP, 2004, FEBS LETT, V569, P191, DOI 10.1016/j.febslet.2004.05.063
French JA, 2004, NEUROLOGY, V62, P1261
Gaida W, 2005, NEUROPHARMACOLOGY, V49, P1220, DOI 10.1016/j.neuropharm.2005.08.004
Ganjehei L, 2011, TEX HEART I J, V38, P344
Garrido JJ, 2003, BIOL CELL, V95, P437, DOI 10.1016/S0248-4900(03)00091-1
Gasser A, 2012, J NEUROSCI, V32, P7232, DOI 10.1523/JNEUROSCI.5434-11.2012
GIARDINA EGV, 1984, ANN NY ACAD SCI, V432, P177, DOI 10.1111/j.1749-6632.1984.tb14519.x
Goldberg YP, 2007, CLIN GENET, V71, P311, DOI 10.1111/j.1399-0004.2007.00790.x
Goldin AL, 2000, NEURON, V28, P365, DOI 10.1016/S0896-6273(00)00116-1
Graff-Radford SB, 2000, CLIN J PAIN, V16, P188, DOI 10.1097/00002508-200009000-00002
Grieco TM, 2005, NEURON, V45, P233, DOI 10.1016/j.neuron.2004.12.035
Grieco TM, 2004, J NEUROSCI, V24, P35, DOI 10.1523/JNEUROSCI.3807-03.2004
Guerrini R, 1998, EPILEPSIA, V39, P508, DOI 10.1111/j.1528-1157.1998.tb01413.x
HAIMOVICH B, 1987, J NEUROSCI, V7, P2957
Hains BC, 2004, J NEUROSCI, V24, P4832, DOI 10.1523/JNEUROSCI.0300-04.2004
Hains BC, 2003, J NEUROSCI, V23, P8881
Hakim P, 2010, ACTA PHYSIOL, V198, P47, DOI 10.1111/j.1748-1716.2009.02048.x
Hakim P, 2008, PROG BIOPHYS MOL BIO, V98, P251, DOI 10.1016/j.pbiomolbio.2009.01.005
Harmer AR, 2011, BRIT J PHARMACOL, V164, P260, DOI 10.1111/j.1476-5381.2011.01415.x
Hasegawa H, 2004, CURR MED RES OPIN, V20, P577, DOI 10.1185/030079904125003313
Heblich Fay, 2008, Channels (Austin), V2, P4
Hedstrom KL, 2006, J NEUROCHEM, V98, P1345, DOI 10.1111/j.1471-4159.2006.04001.x
Hendrich J, 2008, P NATL ACAD SCI USA, V105, P3628, DOI 10.1073/pnas.0708930105
Herfst LJ, 2003, J MOL CELL CARDIOL, V35, P549, DOI 10.1016/S0022-2828(03)00078-6
Hernandez-Plata E, 2012, INT J CANCER, V130, P2013, DOI 10.1002/ijc.26210
Heron SE, 2002, LANCET, V360, P851, DOI 10.1016/S0140-6736(02)09968-3
Hewitt KE, 2001, BRAIN RES, V898, P281, DOI 10.1016/S0006-8993(01)02195-3
HILLE B, 1977, J GEN PHYSIOL, V69, P497, DOI 10.1085/jgp.69.4.497
Hiyama TY, 2004, J NEUROSCI, V24, P9276, DOI 10.1523/JNEUROSCI.2795-04.2004
Hoeijmakers JGJ, 2012, BRAIN, V135, P345, DOI 10.1093/brain/awr349
Holland KD, 2008, NEUROSCI LETT, V433, P65, DOI 10.1016/j.neulet.2007.12.064
Hollmann MW, 2000, ANESTHESIOLOGY, V93, P858, DOI 10.1097/00000542-200009000-00038
Hoyt SB, 2007, BIOORG MED CHEM LETT, V17, P4630, DOI 10.1016/j.bmcl.2007.05.076
Hsueh CH, 2009, J BIOMED SCI, V16, DOI 10.1186/1423-0127-16-23
Hu D, 2009, CIRC-CARDIOVASC GENE, V2, P270, DOI 10.1161/CIRCGENETICS.108.829192
Huth T, 2011, PFLUG ARCH EUR J PHY, V461, P355, DOI 10.1007/s00424-010-0913-2
Iqbal J, 2009, ANN SAUDI MED, V29, P316
ISOM LL, 1992, SCIENCE, V256, P839, DOI 10.1126/science.1375395
Isom LL, 2002, FRONT BIOSCI, V7, P12
Jang HS, 2004, BRIT J DERMATOL, V151, P708, DOI 10.1111/j.1365-2133.2004.06167.x
Jarecki BW, 2008, J PHYSIOL-LONDON, V586, P4137, DOI 10.1113/jphysiol.2008.154906
Jarecki BW, 2010, J CLIN INVEST, V120, P369, DOI 10.1172/JCI40801
Jarvis MF, 2007, P NATL ACAD SCI USA, V104, P8520, DOI 10.1073/pnas.0611364104
Jenkins SM, 2001, J CELL BIOL, V155, P739, DOI 10.1083/jcb.200109026
Jiang YX, 2003, NATURE, V423, P33, DOI 10.1038/nature01580
Jiang YX, 2003, NATURE, V423, P42, DOI 10.1038/nature01581
Joshi SK, 2006, PAIN, V123, P75, DOI 10.1016/j.pain.2006.02.011
Jurkat-Rott K, 2010, PFLUG ARCH EUR J PHY, V460, P239, DOI 10.1007/s00424-010-0814-4
Kalra Arun A, 2007, Ther Clin Risk Manag, V3, P449
Kalume F, 2007, J NEUROSCI, V27, P11065, DOI 10.1523/JNEUROSCI.2162-07.2007
Kaplan MR, 2001, NEURON, V30, P105, DOI 10.1016/S0896-6273(01)00266-5
Kapoor R, 2003, ANN NEUROL, V53, P174, DOI 10.1002/ana.10443
Kapoor R, 2010, LANCET NEUROL, V9, P681, DOI 10.1016/S1474-4422(10)70131-9
Kapoor R, 1997, BRAIN, V120, P647, DOI 10.1093/brain/120.4.647
Kapplinger JD, 2010, HEART RHYTHM, V7, P33, DOI 10.1016/j.hrthm.2009.09.069
Kearney JA, 2002, HUM MOL GENET, V11, P2765, DOI 10.1093/hmg/11.22.2765
Kerr BJ, 2001, NEUROREPORT, V12, P3077, DOI 10.1097/00001756-200110080-00019
Khasar SG, 1998, NEUROSCI LETT, V256, P17, DOI 10.1016/S0304-3940(98)00738-1
Khoromi S, 2005, J PAIN, V6, P829, DOI 10.1016/j.jpain.2005.08.002
Klionsky L, 2006, J PHARMACOL EXP THER, V319, P192, DOI 10.1124/jpet.106.108092
Kort ME, 2008, J MED CHEM, V51, P407, DOI 10.1021/jm070637u
KUDROW L, 1995, HEADACHE, V35, P79, DOI 10.1111/j.1526-4610.1995.hed3502079.x
Kuhnert SM, 1999, ARCH DERMATOL, V135, P1447, DOI 10.1001/archderm.135.12.1447
KUO CC, 1994, NEURON, V12, P819, DOI 10.1016/0896-6273(94)90335-2
Kyndt F, 2001, CIRCULATION, V104, P3081, DOI 10.1161/hc5001.100834
Lai J, 2002, PAIN, V95, P143, DOI 10.1016/S0304-3959(01)00391-8
Lamas JA, 2009, PFLUG ARCH EUR J PHY, V458, P589, DOI 10.1007/s00424-009-0648-0
Lampl I, 1998, J PHARMACOL EXP THER, V284, P228
Lemaillet G, 2003, J BIOL CHEM, V278, P27333, DOI 10.1074/jbc.M303327200
Leo S, 2010, BEHAV BRAIN RES, V208, P149, DOI 10.1016/j.bbr.2009.11.023
Leppik IE, 2004, SEIZURE-EUR J EPILEP, V13, pS5, DOI 10.1016/j.seizure.2004.04.016
Leterrier C, 2010, NEUROSCI LETT, V486, P92, DOI 10.1016/j.neulet.2010.08.079
Levin SI, 2006, J NEUROPHYSIOL, V96, P785, DOI 10.1152/jn.01193.2005
Liao Y, 2010, NEUROLOGY, V75, P1454, DOI 10.1212/WNL.0b013e3181f8812e
Liao YJ, 2008, P NATL ACAD SCI USA, V105, P2705, DOI 10.1073/pnas.0710771105
Lim TKY, 2007, ANESTHESIOLOGY, V107, P305, DOI 10.1097/01.anes.0000270758.77314.b4
Lindia JA, 2005, PAIN, V117, P145, DOI 10.1016/j.pain.2005.05.027
Liu H, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0029395
London C, 2008, BIOORG MED CHEM LETT, V18, P1696, DOI 10.1016/j.bmcl.2008.01.047
Lopez-Santiago Luis F, 2007, J Mol Cell Cardiol, V43, P636, DOI 10.1016/j.yjmcc.2007.07.062
Lopez-Santiago LF, 2006, J NEUROSCI, V26, P7984, DOI 10.1523/JNEUROSCI.2211-06.2006
Mackenzie FE, 2009, GENES BRAIN BEHAV, V8, P699, DOI 10.1111/j.1601-183X.2009.00514.x
Maitre M, 1997, PROG NEUROBIOL, V51, P337, DOI 10.1016/S0301-0082(96)00064-0
Mantegazza M, 2010, LANCET NEUROL, V9, P413, DOI 10.1016/S1474-4422(10)70059-4
Mao JR, 2000, PAIN, V87, P7, DOI 10.1016/S0304-3959(00)00229-3
Marini C, 2009, EPILEPSIA, V50, P1670, DOI 10.1111/j.1528-1167.2009.02013.x
Martin MS, 2007, HUM MOL GENET, V16, P2892, DOI 10.1093/hmg/ddm248
Mattson RH, 1985, N ENGL J MED, V313
McGaraughty S, 2008, J PHARMACOL EXP THER, V324, P1204, DOI 10.1124/jpet.107.134148
McGowan E, 2009, ANESTH ANALG, V109, P951, DOI 10.1213/ane.0b013e3181b01b02
Medeiros-Domingo A, 2007, CIRCULATION, V116, P134, DOI 10.1161/CIRCULATIONAHA.106.659086
Meisler MH, 2005, J CLIN INVEST, V115, P2010, DOI 10.1172/JCI25466
Meisler MH, 2010, J PHYSIOL-LONDON, V588, P1841, DOI 10.1113/jphysiol.2010.188482
Meisler MH, 2002, NOVART FDN SYMP, V241, P72
Meisler MH, 2004, GENETICA, V122, P37, DOI 10.1007/s10709-004-1441-9
Middleton RE, 2002, BIOCHEMISTRY-US, V41, P14734, DOI 10.1021/bi026546a
Minett MS, 2012, NAT COMMUN, V3, DOI 10.1038/ncomms1795
Misra SN, 2008, EPILEPSIA, V49, P1535, DOI 10.1111/j.1528-1167.2008.01619.x
Mohammadi Bahram, 2005, Pharmacogenet Genomics, V15, P235, DOI 10.1097/01213011-200504000-00007
Mohler PJ, 2004, P NATL ACAD SCI USA, V101, P17533, DOI 10.1073/pnas.0403711101
Morrow J, 2006, J NEUROL NEUROSUR PS, V77, P193, DOI 10.1136/jnnp.2005.074203
Muth-Selbach U, 2009, EUR J PHARMACOL, V613, P68, DOI 10.1016/j.ejphar.2009.04.043
Nalamachu S, 2006, J FAM PRACTICE, V55, P209
Nassar MA, 2006, MOL PAIN, V2, DOI 10.1186/1744-8069-2-33
Nassar MA, 2005, MOL PAIN, V1, DOI 10.1186/1744-8069-1-24
Nassar MA, 2004, P NATL ACAD SCI USA, V101, P12706, DOI 10.1073/pnas.0404915101
NATTEL S, 1993, AM J CARDIOL, V72, pF13, DOI 10.1016/0002-9149(93)90959-G
Naylor J, 2008, BRIT J PHARMACOL, V155, P567, DOI 10.1038/bjp.2008.283
Nuyens D, 2001, NAT MED, V7, P1021, DOI 10.1038/nm0901-1021
O'Brien JE, 2012, J BIOL CHEM, V287, P18459, DOI 10.1074/jbc.M111.336024
Okuse K, 2002, NATURE, V417, P653, DOI 10.1038/nature00781
O'Malley HA, 2009, MOL CELL NEUROSCI, V40, P143, DOI 10.1016/j.mcn.2008.10.001
Onkal R, 2009, EUR J PHARMACOL, V625, P206, DOI 10.1016/j.ejphar.2009.08.040
O'Roak BJ, 2012, NATURE, V485, P246, DOI 10.1038/nature10989
O'Roak BJ, 2011, NAT GENET, V43, P585, DOI 10.1038/ng.835
Ostman JAR, 2008, J PHYSIOL-LONDON, V586, P1077, DOI 10.1113/jphysiol.2007.147942
Ou SW, 2005, EUR J NEUROSCI, V22, P793, DOI 10.1111/j.1460-9568.2005.04280.x
Oyama F, 2006, J NEUROCHEM, V98, P518, DOI 10.1111/j.1471-4159.2006.03893.x
Padilla F, 2007, MOL CELL NEUROSCI, V35, P138, DOI 10.1016/j.mcn.2007.02.008
Papadatos GA, 2002, P NATL ACAD SCI USA, V99, P6210, DOI 10.1073/pnas.082121299
Papale LA, 2010, J BIOL CHEM, V285, P16553, DOI 10.1074/jbc.M109.090084
Patino GA, 2011, J NEUROSCI, V31, P14577, DOI 10.1523/JNEUROSCI.0361-11.2011
Patino GA, 2009, J NEUROSCI, V29, P10764, DOI 10.1523/JNEUROSCI.2475-09.2009
Patino GA, 2010, NEUROSCI LETT, V486, P53, DOI 10.1016/j.neulet.2010.06.050
PATLAK JB, 1986, J GEN PHYSIOL, V87, P305, DOI 10.1085/jgp.87.2.305
Payandeh J, 2011, NATURE, V475, P353, DOI 10.1038/nature10238
Payandeh J, 2012, NATURE, V486, P135, DOI 10.1038/nature11077
Pertin M, 2005, J NEUROSCI, V25, P10970, DOI 10.1523/JNEUROSCI.3066-05.2005
Perucca E, 2011, LANCET NEUROL, V10, P446, DOI 10.1016/S1474-4422(11)70047-3
Pittenger C, 2008, CNS DRUGS, V22, P761, DOI 10.2165/00023210-200822090-00004
Planells-Cases R, 2000, BIOPHYS J, V78, P2878
Poolos NP, 2002, NAT NEUROSCI, V5, P767, DOI 10.1038/nn891
Poon WYL, 2004, FEBS LETT, V558, P114, DOI 10.1016/S0014-5793(03)01512-6
Priest BT, 2007, TOXICON, V49, P194, DOI 10.1016/j.toxicon.2006.09.014
Priest BT, 2004, BIOCHEMISTRY-US, V43, P9866, DOI 10.1021/bi0493259
Priest BT, 2005, P NATL ACAD SCI USA, V102, P9382, DOI 10.1073/pnas.0501549102
PTACEK LJ, 1991, CELL, V67, P1021
RAGSDALE DS, 1994, SCIENCE, V265, P1724, DOI 10.1126/science.8085162
Ragsdale DS, 2008, BRAIN RES REV, V58, P149, DOI 10.1016/j.brainresrev.2008.01.003
Ragsdale DS, 1996, P NATL ACAD SCI USA, V93, P9270, DOI 10.1073/pnas.93.17.9270
Rajakulendran S, 2009, NEUROLOGY, V73, P993, DOI 10.1212/WNL.0b013e3181b87959
Raman IM, 1997, NEURON, V19, P881, DOI 10.1016/S0896-6273(00)80969-1
Raman IM, 1997, J NEUROSCI, V17, P4517
Rauck RL, 2007, CLIN J PAIN, V23, P150, DOI 10.1097/01.ajp.0000210957.39621.b2
Renganathan M, 2001, J NEUROPHYSIOL, V86, P629
Rivera-Acevedo RE, 2011, ANESTHESIOLOGY, V114, P1425, DOI 10.1097/ALN.0b013e318216ea0c
Roberson DP, 2011, BRIT J PHARMACOL, V164, P48, DOI 10.1111/j.1476-5381.2011.01391.x
Robinson LR, 2004, ARCH PHYS MED REHAB, V85, P1, DOI 10.1016/S0003-00473-3
ROGART RB, 1989, P NATL ACAD SCI USA, V86, P8170, DOI 10.1073/pnas.86.20.8170
Rogawski MA, 2004, NAT MED, V10, P685, DOI 10.1038/nm1074
Roselli Francesco, 2006, Recent Pat CNS Drug Discov, V1, P83, DOI 10.2174/157488906775245255
Rosker C, 2007, AM J PHYSIOL-CELL PH, V293, pC783, DOI 10.1152/ajpcell.00070.2007
Ruan YF, 2010, CIRC RES, V106, P1374, DOI 10.1161/CIRCRESAHA.110.218891
Ruetsch Yvan A., 2001, Current Topics in Medicinal Chemistry, V1, P175, DOI 10.2174/1568026013395335
Rugiero F, 2003, J NEUROSCI, V23, P2715
Rusconi R, 2007, J NEUROSCI, V27, P11037, DOI 10.1523/JNEUROSCI.3515-07.2007
Saenen JB, 2008, J MOL CELL CARDIOL, V44, P633, DOI 10.1016/j.yjmcc.2008.01.006
Saleh S, 2005, J PHYSIOL-LONDON, V568, P155, DOI 10.1113/jphysiol.2005.090951
Sanders SJ, 2012, NATURE, V485, P237, DOI 10.1038/nature10945
Scheffer IE, 2007, BRAIN, V130, P100, DOI 10.1093/brain/awl272
Schiavon E, 2006, J BIOL CHEM, V281, P20326, DOI 10.1074/jbc.M600565200
Schmalhofer WA, 2008, MOL PHARMACOL, V74, P1476, DOI 10.1124/mol.108.047670
SCHWARZ JR, 1989, EPILEPSIA, V30, P286, DOI 10.1111/j.1528-1157.1989.tb05300.x
Schwarz SKW, 2010, ANESTHESIOLOGY, V113, P438, DOI 10.1097/ALN.0b013e3181dfd31b
SCHWINDT PC, 1995, J NEUROPHYSIOL, V74, P2220
Shank RP, 2008, CNS NEUROSCI THER, V14, P120, DOI 10.1111/j.1527-3458.2008.00041.x
Shao DM, 2009, INT J BIOCHEM CELL B, V41, P1471, DOI 10.1016/j.biocel.2009.01.016
Shao PP, 2005, BIOORG MED CHEM LETT, V15, P1901, DOI 10.1016/j.bmcl.2005.02.002
Sheets PL, 2008, J PHARMACOL EXP THER, V326, P89, DOI 10.1124/jpet.107.133413
Sheets PL, 2007, J PHYSIOL-LONDON, V581, P1019, DOI 10.1113/jphysiol.2007.127027
Sijben AEJ, 2009, EPILEPSIA, V50, P953, DOI 10.1111/j.1528-1167.2009.02023.x
Smith DB, 1987, EPILEPSIA S3, V28, P50
Smith KJ, 2007, BRAIN PATHOL, V17, P230, DOI 10.1111/j.1750-3639.2007.00066.x
Sokolov S, 2007, NATURE, V446, P76, DOI 10.1038/nature05598
Sokolov S, 2010, J GEN PHYSIOL, V136, P225, DOI 10.1085/jgp.201010414
Song JH, 2000, EUR J PHARMACOL, V401, P297, DOI 10.1016/S0014-2999(00)00460-X
Spampanato J, 2001, J NEUROSCI, V21, P7481
STARMER CF, 1985, J THEOR BIOL, V115, P337, DOI 10.1016/S0022-5193(85)80196-X
Stefani A, 1996, EUR J PHARMACOL, V307, P113, DOI 10.1016/0014-2999(96)00265-8
Stevens EB, 2001, PFLUG ARCH EUR J PHY, V441, P481, DOI 10.1007/s004240000449
Stohr T, 2006, EUR J PAIN, V10, P241, DOI 10.1016/j.ejpain.2005.04.002
STUHMER W, 1989, NATURE, V339, P597, DOI 10.1038/339597a0
Stummann TC, 2005, EUR J PHARMACOL, V510, P197, DOI 10.1016/j.ejphar.2005.01.030
Stys PK, 2004, CURR MOL MED, V4, P113, DOI 10.2174/1566524043479220
Sugawara T, 2001, P NATL ACAD SCI USA, V98, P6384, DOI 10.1073/pnas.111065098
Sun GC, 2007, EPILEPSIA, V48, P774, DOI 10.1111/j.1528-1167.2007.01001.x
Tan BH, 2010, HEART RHYTHM, V7, P771, DOI 10.1016/j.hrthm.2010.01.032
Taverna S, 1998, EPILEPSY RES, V32, P304, DOI 10.1016/S0920-1211(98)00060-6
Theile JW, 2011, J PHYSIOL-LONDON, V589, P597, DOI 10.1113/jphysiol.2010.200915
ToledoAral JJ, 1997, P NATL ACAD SCI USA, V94, P1527, DOI 10.1073/pnas.94.4.1527
Trudeau MM, 2006, J MED GENET, V43, P527, DOI 10.1136/jmg.2005.035667
Uebachs M, 2010, J NEUROSCI, V30, P8489, DOI 10.1523/JNEUROSCI.1534-10.2010
Vahedi K, 2009, NEUROLOGY, V72, P1178, DOI 10.1212/01.wnl.0000345393.53132.8c
Valdivia CR, 2010, CARDIOVASC RES, V86, P392, DOI 10.1093/cvr/cvp417
Valdivia CR, 2002, CARDIOVASC RES, V55, P279, DOI 10.1016/S0008-6363(02)00445-5
Valdivia CR, 2004, CARDIOVASC RES, V62, P53, DOI 10.1016/j.cardiores.2004.01.022
VASSILEV P, 1989, P NATL ACAD SCI USA, V86, P8147, DOI 10.1073/pnas.86.20.8147
VASSILEV PM, 1988, SCIENCE, V241, P1658, DOI 10.1126/science.2458625
Veeramah KR, 2012, AM J HUM GENET, V90, P502, DOI 10.1016/j.ajhg.2012.01.006
Veneroni O, 2003, PAIN, V102, P17, DOI 10.1016/S0304-3959(02)00183-5
Volkers L, 2011, EUR J NEUROSCI, V34, P1268, DOI 10.1111/j.1460-9568.2011.07826.x
von Gunten CF, 2007, PALLIATIVE MED, V21, P667, DOI 10.1177/0269216307083031
Walker MJ, 2006, BRIT J PHARMACOL, V147, P222
Wang PY, 2010, BIOCHEM BIOPH RES CO, V398, P98, DOI 10.1016/j.bbrc.2010.06.042
Wang YY, 2010, J BIOL CHEM, V285, P25296, DOI 10.1074/jbc.M110.128801
Wang YY, 2011, TRANSL NEUROSCI, V2, P13, DOI 10.2478/s13380-011-0002-9
WANG ZG, 1993, J PHARMACOL EXP THER, V267, P575
Watanabe E, 2000, J NEUROSCI, V20, P7743
Watanabe H, 2009, CIRC-ARRHYTHMIA ELEC, V2, P268, DOI 10.1161/CIRCEP.108.779181
Watanabe H, 2008, J CLIN INVEST, V118, P2260, DOI [10.1172/JCI33891, 10.1172/JC133891]
WAXMAN SG, 1994, BRAIN RES, V644, P197, DOI 10.1016/0006-8993(94)91680-2
WAXMAN SG, 1994, J NEUROPHYSIOL, V72, P466
Weiser T, 2002, MOL PHARMACOL, V62, P433, DOI 10.1124/mol.62.3.433
Weiss J, 2011, NATURE, V472, P186, DOI 10.1038/nature09975
Weiss LA, 2003, MOL PSYCHIATR, V8, P186, DOI 10.1038/sj.mp.4001241
Weiss S, 2010, BRIT J PHARMACOL, V160, P1072, DOI 10.1111/j.1476-5381.2010.00766.x
WEST JW, 1992, P NATL ACAD SCI USA, V89, P10910, DOI 10.1073/pnas.89.22.10910
WESTENBROEK RE, 1989, NEURON, V3, P695, DOI 10.1016/0896-6273(89)90238-9
WESTENBROEK RE, 1992, J NEUROSCI, V12, P2259
Whitaker WRJ, 2001, MOL BRAIN RES, V88, P37, DOI 10.1016/S0169-328X(00)00289-8
Wiffen PJ, 2011, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD005451.pub2
Williams BS, 2007, BIOCHEMISTRY-US, V46, P14693, DOI 10.1021/bi7018207
Wilson MJ, 2011, J PHARMACOL EXP THER, V338, P687, DOI 10.1124/jpet.110.178343
Wimmer VC, 2010, J CLIN INVEST, V120, P2661, DOI 10.1172/JCI42219
Wong HK, 2005, J BIOL CHEM, V280, P23009, DOI 10.1074/jbc.M414648200
Wood JN, 2004, J NEUROBIOL, V61, P55, DOI 10.1002/neu.20094
Yang Y, 2004, J MED GENET, V41, P171, DOI 10.1136/jmg.2003.012153
Yarbrough TL, 2002, CIRC RES, V90, P443, DOI 10.1161/hh0402.105177
Yarov-Yarovoy V, 2012, P NATL ACAD SCI USA, V109, pE93, DOI 10.1073/pnas.1118434109
Yu FH, 2003, J NEUROSCI, V23, P7577
Yu FH, 2006, NAT NEUROSCI, V9, P1142, DOI 10.1038/nn1754
Zhao J, 2011, J NEUROPHYSIOL, V106, P608, DOI 10.1152/jn.00107.2011
Zimmer T, 2008, PROG BIOPHYS MOL BIO, V98, P120, DOI 10.1016/j.pbiomolbio.2008.10.005
Zimmermann K, 2007, NATURE, V447, P855, DOI 10.1038/nature05880
Zona C, 2002, EPILEPSIA, V43, P685, DOI 10.1046/j.1528-1157.2002.51401.x
NR 339
TC 52
Z9 55
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0006-8950
J9 BRAIN
JI Brain
PD SEP
PY 2012
VL 135
BP 2585
EP 2612
DI 10.1093/brain/aws225
PN 9
PG 28
WC Clinical Neurology; Neurosciences
SC Neurosciences & Neurology
GA 007FG
UT WOS:000308873600005
PM 22961543
ER
PT J
AU Gotts, SJ
Simmons, WK
Milbury, LA
Wallace, GL
Cox, RW
Martin, A
AF Gotts, Stephen J.
Simmons, W. Kyle
Milbury, Lydia A.
Wallace, Gregory L.
Cox, Robert W.
Martin, Alex
TI Fractionation of social brain circuits in autism spectrum disorders
SO BRAIN
LA English
DT Article
DE autism spectrum disorders; functional connectivity; resting state
functional MRI; limbic system; cluster analysis
ID INTRINSIC FUNCTIONAL ARCHITECTURE; CEREBRAL-CORTEX; DIAGNOSTIC
INTERVIEW; DEFAULT NETWORK; NEURAL BASIS; CONNECTIVITY; FMRI; STATE;
COGNITION; AMYGDALA
AB Autism spectrum disorders are developmental disorders characterized by impairments in social and communication abilities and repetitive behaviours. Converging neuroscientific evidence has suggested that the neuropathology of autism spectrum disorders is widely distributed, involving impaired connectivity throughout the brain. Here, we evaluate the hypothesis that decreased connectivity in high-functioning adolescents with an autism spectrum disorder relative to typically developing adolescents is concentrated within domain-specific circuits that are specialized for social processing. Using a novel whole-brain connectivity approach in functional magnetic resonance imaging, we found that not only are decreases in connectivity most pronounced between regions of the social brain but also they are selective to connections between limbic-related brain regions involved in affective aspects of social processing from other parts of the social brain that support language and sensorimotor processes. This selective pattern was independently obtained for correlations with measures of social symptom severity, implying a fractionation of the social brain in autism spectrum disorders at the level of whole circuits.
C1 [Gotts, Stephen J.; Milbury, Lydia A.; Wallace, Gregory L.; Martin, Alex] NIMH, Sect Cognit Neuropsychol, Lab Brain & Cognit, NIH, Bethesda, MD 20892 USA.
[Simmons, W. Kyle] Laureate Inst Brain Res, Tulsa, OK 74136 USA.
RP Gotts, SJ (reprint author), NIMH, Sect Cognit Neuropsychol, Lab Brain & Cognit, NIH, Bethesda, MD 20892 USA.
EM gottss@mail.nih.gov
RI Gotts, Stephen/J-4842-2012
FU National Institute of Mental Health, NIH, Division of Intramural
Research
FX This study was supported by the National Institute of Mental Health,
NIH, Division of Intramural Research.
CR Adolphs R, 2006, PROG BRAIN RES, V156, P363, DOI 10.1016/S0079-6123(06)56020-0
Adolphs R, 2010, ANN NY ACAD SCI, V1191, P42, DOI 10.1111/j.1749-6632.2010.05445.x
Adolphs R, 2009, ANNU REV PSYCHOL, V60, P693, DOI 10.1146/annurev.psych.60.110707.163514
Amaral DG, 2008, TRENDS NEUROSCI, V31, P137, DOI 10.1016/j.tins.2007.12.005
Amodio DM, 2006, NAT REV NEUROSCI, V7, P268, DOI 10.1038/nrn1884
Anderson JS, 2011, CEREB CORTEX, V21, P1134, DOI 10.1093/cercor/bhq190
Anderson JS, 2011, BRAIN, V134, P3739, DOI 10.1093/brain/awr263
Andrews-Hanna JR, 2010, J NEUROPHYSIOL, V104, P322, DOI 10.1152/jn.00830.2009
Andrews-Hanna JR, 2010, NEURON, V65, P550, DOI 10.1016/j.neuron.2010.02.005
Assaf M, 2010, NEUROIMAGE, V53, P247, DOI 10.1016/j.neuroimage.2010.05.067
Beauchamp MS, 2003, J COGNITIVE NEUROSCI, V15, P991, DOI 10.1162/089892903770007380
Belmonte MK, 2004, J NEUROSCI, V24, P9228, DOI 10.1523/JNEUROSCI.3340-04.2004
Birn RM, 2008, NEUROIMAGE, V40, P644, DOI 10.1016/j.neuroimage.2007.11.059
Blakemore SJ, 2008, NAT REV NEUROSCI, V9, P267, DOI 10.1038/nrn2353
Booth R, 2011, PROG BRAIN RES, V189, P303, DOI 10.1016/B978-0-444-53884-0.00031-2
Brothers L., 1990, CONCEPTS NEUROSCIENC, V1, P27
Buckner RL, 2009, J NEUROSCI, V29, P1860, DOI 10.1523/JNEUROSCI.5062-08.2009
Carmichael ST, 1995, J COMP NEUROL, V363, P615, DOI 10.1002/cne.903630408
Castelli F, 2002, BRAIN, V125, P1839, DOI 10.1093/brain/awf189
Cavanna AE, 2006, BRAIN, V129, P564, DOI 10.1093/brain/awl004
Chao LL, 1999, NAT NEUROSCI, V2, P913
Cole MW, 2010, NEUROIMAGE, V49, P3132, DOI 10.1016/j.neuroimage.2009.11.001
Constantino JN, 2002, SOCIAL RESPONSIVENES
Cordes D, 2001, AM J NEURORADIOL, V22, P1326
Cox RW, 1996, COMPUT BIOMED RES, V29, P162, DOI 10.1006/cbmr.1996.0014
Deen B, 2010, NEUROPSYCHOLOGIA, V48, P1607, DOI 10.1016/j.neuropsychologia.2010.01.028
Di Martino A, 2009, BIOL PSYCHIAT, V65, P63, DOI 10.1016/j.biopsych.2008.09.022
Dinstein I, 2011, NEURON, V70, P1218, DOI 10.1016/j.neuron.2011.04.018
Duncan J, 2000, SCIENCE, V289, P457, DOI 10.1126/science.289.5478.457
Ebisch SJH, 2011, HUM BRAIN MAPP, V32, P1013, DOI 10.1002/hbm.21085
Fanselow MS, 2010, NEURON, V65, P7, DOI 10.1016/j.neuron.2009.11.031
Felleman DJ, 1991, CEREB CORTEX, V1, P1, DOI 10.1093/cercor/1.1.1
Fischl B, 2002, NEURON, V33, P341, DOI 10.1016/S0896-6273(02)00569-X
Fox MD, 2005, P NATL ACAD SCI USA, V102, P9673, DOI 10.1073/pnas.0504136102
Fox MD, 2007, NAT REV NEUROSCI, V8, P700, DOI 10.1038/nrn2201
Fox Michael D, 2010, Front Syst Neurosci, V4, P19, DOI 10.3389/fnsys.2010.00019
Fransson P, 2007, P NATL ACAD SCI USA, V104, P15531, DOI 10.1073/pnas.0704380104
Friston KJ, 1997, NEUROIMAGE, V6, P218, DOI 10.1006/nimg.1997.0291
Friston KJ, 2003, NEUROIMAGE, V19, P1273, DOI 10.1016/S1053-8119(03)00202-7
Frith CD, 2007, CURR BIOL, V17, pR724, DOI 10.1016/j.cub.2007.05.068
Frith CD, 2007, PHILOS T R SOC B, V362, P671, DOI 10.1098/rstb.2006.2003
Geake JG, 2005, NEUROIMAGE, V26, P555, DOI 10.1016/j.neuroimage.2005.01.035
Glover GH, 2000, MAGNET RESON MED, V44, P162, DOI 10.1002/1522-2594(200007)44:1<162::AID-MRM23>3.0.CO;2-E
Hamilton AFD, 2006, J NEUROSCI, V26, P1133, DOI 10.1523/JNEUROSCI.4551-05.2006
Honey CJ, 2009, P NATL ACAD SCI USA, V106, P2035, DOI 10.1073/pnas.0811168106
Jeste SS, 2011, CURR OPIN NEUROL, V24, P132, DOI 10.1097/WCO.0b013e3283446450
Jo HJ, 2010, NEUROIMAGE, V52, P571, DOI 10.1016/j.neuroimage.2010.04.246
Just MA, 2007, CEREB CORTEX, V17, P951, DOI 10.1093/cercor/bhl006
Just MA, 2004, BRAIN, V127, P1811, DOI 10.1093/brain/awh199
Kanwisher N, 1997, J NEUROSCI, V17, P4302
KEMPER TL, 1993, NEUROL CLIN, V11, P175
Kennedy DP, 2008, NEUROIMAGE, V39, P1877, DOI 10.1016/j.neuroimage.2007.10.052
Kleinhans NM, 2008, BRAIN, V131, P1000, DOI 10.1093/brain/awm334
Kravitz DJ, 2010, CEREB CORTEX, V20, P2916, DOI 10.1093/cercor/bhq042
Lainhart JE, 2006, AM J MED GENET A, V140A, P2257, DOI 10.1002/ajmg.a.31465
Larson-Prior LJ, 2009, P NATL ACAD SCI USA, V106, P4489, DOI 10.1073/pnas.0900924106
LECOUTEUR A, 1989, J AUTISM DEV DISORD, V19, P363
Lieberman MD, 2009, SOC COGN AFFECT NEUR, V4, P423, DOI 10.1093/scan/nsp052
Lombardo MV, 2010, BRAIN, V133, P611, DOI 10.1093/brain/awp306
LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
Margulies DS, 2009, P NATL ACAD SCI USA, V106, P20069, DOI 10.1073/pnas.0905314106
Maris E., 2007, J NEUROSCI METH, V25, P2862
Markram K, 2010, FRONT HUM NEUROSCI, V4, DOI 10.3389/fnhum.2010.00224
Mason MF, 2007, SCIENCE, V315, P393, DOI 10.1126/science.1131295
Mitchell JP, 2009, TRENDS COGN SCI, V13, P246, DOI 10.1016/j.tics.2009.03.008
Monk CS, 2009, NEUROIMAGE, V47, P764, DOI 10.1016/j.neuroimage.2009.04.069
Mostofsky SH, 2009, BRAIN, V132, P2413, DOI 10.1093/brain/awp088
Muller RA, 2011, CEREB CORTEX, V21, P2233, DOI 10.1093/cercor/bhq296
Murphy K, 2009, NEUROIMAGE, V44, P893, DOI 10.1016/j.neuroimage.2008.09.036
Olson IR, 2007, BRAIN, V130, P1718, DOI 10.1093/brain/awm052
Raznahan A, 2010, CEREB CORTEX, V20, P1332, DOI 10.1093/cercor/bhp198
Saad ZS, 2012, BRAIN CONNECT
Saleem KS, 2008, J COMP NEUROL, V506, P659, DOI 10.1002/ene.21577
Sallet J, 2011, SCIENCE, V334, P697, DOI 10.1126/science.1210027
Salomon R, 2011, J NEUROSCI, V31, P12972, DOI 10.1523/JNEUROSCI.2987-11.2011
Samson D, 2004, NAT NEUROSCI, V7, P499, DOI 10.1038/nn1223
Schipul Sarah E, 2011, Front Syst Neurosci, V5, P10, DOI 10.3389/fnsys.2011.00010
Schumann CM, 2004, J NEUROSCI, V24, P6392, DOI 10.1523/JNEUROSCI.1297-04.2004
Schumann CM, 2006, J NEUROSCI, V26, P7674, DOI 10.1523/JNEUROSCI.1285-06.2006
Shaw P, 2008, J NEUROSCI, V28, P3586, DOI 10.1523/JNEUROSCI.5309-07.2008
Simmons WK, 2009, J INT NEUROPSYCH SOC, V15, P645, DOI 10.1017/S1355617709990348
Simmons WK, 2012, SOC COGN AFFECT NEUR, V7, P467, DOI 10.1093/scan/nsr018
Singer T, 2004, SCIENCE, V303, P1157, DOI 10.1126/science.1093535
Talairach J., 1988, COPLANAR STEREOTAXIC
Turken AU, 2011, FRONT SYST NEUROSCI, V1, P20
Vattikuti S, 2010, BIOL PSYCHIAT, V67, P672, DOI 10.1016/j.biopsych.2009.09.008
Vincent JL, 2007, NATURE, V447, P83, DOI 10.1038/nature05758
Vissers ME, 2012, NEUROSCI BIOBEHAV R, V36, P604, DOI 10.1016/j.neubiorev.2011.09.003
Voineagu I, 2011, NATURE, V474, P380, DOI 10.1038/nature10110
von dem Hagen EAH, 2009, SOC COGN AFFECT NEUR, V4, P379, DOI 10.1093/scan/nsp018
Vul E, 2009, PERSPECT PSYCHOL SCI, V4, P274, DOI 10.1111/j.1745-6924.2009.01125.x
Wallace GL, 2010, BRAIN, V133, P3745, DOI 10.1093/brain/awq279
Weng SJ, 2010, BRAIN RES, V1313, P202, DOI 10.1016/j.brainres.2009.11.057
Wiggett AJ, 2009, NEUROPSYCHOLOGIA, V47, P3111, DOI 10.1016/j.neuropsychologia.2009.07.008
Yizhar O, 2011, NATURE, V477, P171, DOI 10.1038/nature10360
NR 96
TC 46
Z9 46
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0006-8950
J9 BRAIN
JI Brain
PD SEP
PY 2012
VL 135
BP 2711
EP 2725
DI 10.1093/brain/aws160
PN 9
PG 15
WC Clinical Neurology; Neurosciences
SC Neurosciences & Neurology
GA 007FG
UT WOS:000308873600013
PM 22791801
ER
PT J
AU Ercan-Sencicek, AG
Wright, NRD
Frost, SJ
Fulbright, RK
Felsenfeld, S
Hart, L
Landi, N
Mencl, WE
Sanders, SJ
Pugh, KR
State, MW
Grigorenko, EL
AF Ercan-Sencicek, A. Gulhan
Wright, Nicole R. Davis
Frost, Stephen J.
Fulbright, Robert K.
Felsenfeld, Susan
Hart, Lesley
Landi, Nicole
Mencl, W. Einar
Sanders, Stephan J.
Pugh, Kenneth R.
State, Matthew W.
Grigorenko, Elena L.
TI Searching for Potocki-Lupski syndrome phenotype: A patient with language
impairment and no autism
SO BRAIN & DEVELOPMENT
LA English
DT Article
DE Language and speech impairment; Potocki-Lupski syndrome; 17p11.2,
EFCBP1; inv(8)(q21.3-q24.1)
ID DUP(17)(P11.2P11.2); MODEL; GENE
AB Potocki-Lupski syndrome (PTLS; OMIM 610883) is a genomic syndrome that arises as a result of a duplication of 17p11.2. Although numerous cases of individuals with PTLS have been presented in the literature, its behavioral characterization is still ambiguous. We present a male child with a de novo dup(17)(p11.2p11.2) and he does not possess any autistic features, but is characterized by severe speech and language impairment. In the context of the analyses of this patient and other cases of PTLS, we argue that the central feature of the syndrome appears to be related to diminished speech and language capacity, rather than the specific social deficits central to autism. (C) Published by Elsevier B.V. on behalf of The Japanese Society of Child Neurology.
C1 [Ercan-Sencicek, A. Gulhan; Wright, Nicole R. Davis; Sanders, Stephan J.; State, Matthew W.] Yale Univ, Sch Med, Program Neurogenet, New Haven, CT 06520 USA.
[Ercan-Sencicek, A. Gulhan; Wright, Nicole R. Davis; Hart, Lesley; Landi, Nicole; Sanders, Stephan J.; State, Matthew W.; Grigorenko, Elena L.] Yale Univ, Sch Med, Ctr Child Study, New Haven, CT 06519 USA.
[Ercan-Sencicek, A. Gulhan; Wright, Nicole R. Davis; Sanders, Stephan J.; State, Matthew W.] Yale Univ, Sch Med, Dept Genet, New Haven, CT 06520 USA.
[Sanders, Stephan J.; State, Matthew W.] Yale Univ, Sch Med, Dept Psychiat, New Haven, CT 06520 USA.
[Frost, Stephen J.; Fulbright, Robert K.; Felsenfeld, Susan; Landi, Nicole; Mencl, W. Einar; Pugh, Kenneth R.; Grigorenko, Elena L.] Yale Univ, Sch Med, Haskins Labs, New Haven, CT 06520 USA.
Yale Univ, Sch Med, Haskins Labs, New Haven, CT 06520 USA.
[Fulbright, Robert K.] Yale Univ, Sch Med, Magnet Resonance Res Ctr, New Haven, CT 06520 USA.
[Felsenfeld, Susan] So Connecticut State Univ, Storrs, CT USA.
[Pugh, Kenneth R.] Univ Connecticut, Dept Psychol, Storrs, CT USA.
[Pugh, Kenneth R.] Yale Univ, Dept Linguist, New Haven, CT 06520 USA.
[Pugh, Kenneth R.] Yale Univ, Sch Med, Dept Diagnost Radiol, New Haven, CT 06520 USA.
[Grigorenko, Elena L.] Yale Univ, Sch Med, Dept Psychol, New Haven, CT 06520 USA.
[Grigorenko, Elena L.] Yale Univ, Sch Med, Dept Epidemiol & Publ Hlth, New Haven, CT 06520 USA.
[Grigorenko, Elena L.] Columbia Univ, Teachers Coll, New York, NY 10027 USA.
[Grigorenko, Elena L.] Moscow MV Lomonosov State Univ, Dept Psychol, Moscow, Russia.
RP State, MW (reprint author), Yale Child Study Ctr, POB 207900, 230 S Frontage Rd, New Haven, CT 06520 USA.
EM matthew.state@yale.edu; elena.grigorenko@yale.edu
RI Landi, Nicole /P-2954-2014
OI Landi, Nicole /0000-0003-2890-2519
FU Overlook International Foundation (PI State); Shepherd Fund (PI State);
US National Institutes of Health, NIH [DC007665, HD048830, P01HD001994,
HD052120]
FX The preparation of this article was supported by funds from the Overlook
International Foundation (PI State), the Shepherd Fund (PI State), and
the US National Institutes of Health, NIH (awards DC007665, PI
Grigorenko; HD048830, PI Pugh; P01HD001994, PI Fowler; and HD052120, PI
Wagner). Grantees undertaking such projects are encouraged to freely
express their professional judgment. This article, therefore, does not
necessarily represent the position or policies of the NIH and no
official endorsement should be inferred. We are thankful to Drs. Elisa
Mambrino and Jodi Reich for their contributions to the clinical
evaluations of this patient. We are also thankful to Ms. Mei Tan for her
editorial assistance. Last, and foremost, we are grateful to the
patient's family.
CR Chan WM, 2006, J MED GENET, V43, DOI 10.1136/jmg.2005.035436
Girirajan S, 2010, NAT GENET, V42, P203, DOI 10.1038/ng.534
Greco D, 2008, CLIN GENET, V73, P294, DOI 10.1111/j.1399-0004.2007.00959.x
McFarland David H., 2006, Seminars in Speech and Language, V27, P300, DOI 10.1055/s-2006-955/119
Mizuno K, 2005, DEV MED CHILD NEUROL, V47, P299, DOI 10.1017/S0012162205000587
Molina J, 2008, HUM MOL GENET, V17, P2486, DOI 10.1093/hmg/ddn148
Potocki L, 2007, AM J HUM GENET, V80, P633, DOI 10.1086/512864
Treadwell-Deering DE, 2010, J DEV BEHAV PEDIATR, V31, P137, DOI 10.1097/DBP.0b013e3181cda67e
Wu H, 2007, DNA SEQUENCE, V18, P73, DOI 10.1080/10425170500511271
Yoshizawa K, 2003, EXP ANIM TOKYO, V52, P391, DOI 10.1538/expanim.52.391
NR 10
TC 1
Z9 1
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0387-7604
J9 BRAIN DEV-JPN
JI Brain Dev.
PD SEP
PY 2012
VL 34
IS 8
BP 700
EP 703
DI 10.1016/j.braindev.2011.11.003
PG 4
WC Clinical Neurology
SC Neurosciences & Neurology
GA 994BX
UT WOS:000307907000014
ER
PT J
AU Ming, X
Julu, POO
Brimacombe, M
Connor, S
Daniels, ML
AF Ming, Xue
Julu, Peter O. O.
Brimacombe, Michael
Connor, Susan
Daniels, Mary L.
TI Reduced cardiac parasympathetic activity in children with autism (vol
27, pg 509, 2005)
SO BRAIN & DEVELOPMENT
LA English
DT Correction
C1 [Ming, Xue] Univ Med & Dent New Jersey, New Jersey Med Sch, Dept Neurosci, Newark, NJ 07103 USA.
[Ming, Xue] Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Ctr Childhood Exposure & Assessment, Piscataway, NJ 08854 USA.
[Julu, Peter O. O.] Cent Middlesex Hosp, Dept Neurol, Peripheral Nerve & Auton Unit, London NW10 7NS, England.
[Brimacombe, Michael; Daniels, Mary L.] Univ Med & Dent New Jersey, Sch Publ Hlth, Dept Prevent Med, Newark, NJ 07103 USA.
[Connor, Susan] Kennedy Krieger Inst, Dept Neurol & Dev Med, Baltimore, MD 21205 USA.
RP Ming, X (reprint author), Univ Med & Dent New Jersey, New Jersey Med Sch, Dept Neurosci, 90 Bergen St,DOC 8100, Newark, NJ 07103 USA.
EM mingxu@umdnj.edu
CR XUE M, 2005, BRAIN DEV-JPN, V27, P509, DOI DOI 10.1016/J.BRAINDEV.2005.01.003
NR 1
TC 0
Z9 0
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0387-7604
J9 BRAIN DEV-JPN
JI Brain Dev.
PD SEP
PY 2012
VL 34
IS 8
BP 704
EP 704
DI 10.1016/j.braindev.2012.07.011
PG 1
WC Clinical Neurology
SC Neurosciences & Neurology
GA 994BX
UT WOS:000307907000015
ER
PT J
AU Morrison, RD
Blobaum, AL
Byers, FW
Santomango, TS
Bridges, TM
Stec, D
Brewer, KA
Sanchez-Ponce, R
Corlew, MM
Rush, R
Felts, AS
Manka, J
Bates, BS
Venable, DF
Rodriguez, AL
Jones, CK
Niswender, CM
Conn, PJ
Lindsley, CW
Emmitte, KA
Daniels, JS
AF Morrison, Ryan D.
Blobaum, Anna L.
Byers, Frank W.
Santomango, Tammy S.
Bridges, Thomas M.
Stec, Donald
Brewer, Katrina A.
Sanchez-Ponce, Raymundo
Corlew, Melany M.
Rush, Roger
Felts, Andrew S.
Manka, Jason
Bates, Brittney S.
Venable, Daryl F.
Rodriguez, Alice L.
Jones, Carrie K.
Niswender, Colleen M.
Conn, P. Jeffrey
Lindsley, Craig W.
Emmitte, Kyle A.
Daniels, J. Scott
TI The Role of Aldehyde Oxidase and Xanthine Oxidase in the
Biotransformation of a Novel Negative Allosteric Modulator of
Metabotropic Glutamate Receptor Subtype 5
SO DRUG METABOLISM AND DISPOSITION
LA English
DT Article
ID IN VIVO CORRELATION; HUMAN LIVER; METABOLISM; VITRO; PHARMACOKINETICS;
INHIBITOR; PREDICTION; TOXICITY; HUMANS; ENZYME
AB Negative allosteric modulation (NAM) of metabotropic glutamate receptor subtype 5 (mGlu(5)) represents a therapeutic strategy for the treatment of childhood developmental disorders, such as fragile X syndrome and autism. VU0409106 emerged as a lead compound within a biaryl ether series, displaying potent and selective inhibition of mGlu5. Despite its high clearance and short half-life, VU0409106 demonstrated efficacy in rodent models of anxiety after extravascular administration. However, lack of a consistent correlation in rat between in vitro hepatic clearance and in vivo plasma clearance for the biaryl ether series prompted an investigation into the biotransformation of VU0409106 using hepatic subcellular fractions. An in vitro appraisal in rat, monkey, and human liver S9 fractions indicated that the principal pathway was NADPH-independent oxidation to metabolite M1 (+16 Da). Both raloxifene (aldehyde oxidase inhibitor) and allopurinol (xanthine oxidase inhibitor) attenuated the formation of M1, thus implicating the contribution of both molybdenum hydroxylases in the biotransformation of VU0409106. The use of O-18-labeled water in the S9 experiments confirmed the hydroxylase mechanism proposed, because O-18 was incorporated into M1 (+18 Da) as well as in a secondary metabolite (M2; +36 Da), the formation of which was exclusively xanthine oxidase-mediated. This unusual dual and sequential hydroxylase metabolism was confirmed in liver S9 and hepatocytes of multiple species and correlated with in vivo data because M1 and M2 were the principal metabolites detected in rats administered VU0409106. An in vitro-in vivo correlation of predicted hepatic and plasma clearance was subsequently established for VU0409106 in rats and nonhuman primates.
C1 [Morrison, Ryan D.; Blobaum, Anna L.; Byers, Frank W.; Santomango, Tammy S.; Bridges, Thomas M.; Brewer, Katrina A.; Felts, Andrew S.; Manka, Jason; Bates, Brittney S.; Venable, Daryl F.; Rodriguez, Alice L.; Jones, Carrie K.; Niswender, Colleen M.; Conn, P. Jeffrey; Lindsley, Craig W.; Emmitte, Kyle A.; Daniels, J. Scott] Vanderbilt Univ, Med Ctr, Vanderbilt Ctr Neurosci Drug Discovery, Nashville, TN 37232 USA.
[Stec, Donald] Vanderbilt Univ, Dept Chem, Nashville, TN 37232 USA.
[Sanchez-Ponce, Raymundo; Corlew, Melany M.; Rush, Roger] Seaside Therapeut Inc, Preclin Dev, Cambridge, MA USA.
RP Daniels, JS (reprint author), Vanderbilt Univ, Med Ctr, Vanderbilt Ctr Neurosci Drug Discovery, Nashville, TN 37232 USA.
EM scott.daniels@vanderbilt.edu
FU National Institutes of Health National Institute of Mental Health
[5-R01-MH62646-13]; National Institutes of Health National Institute of
Neurological Disorders and Stroke [2-R01-NS31373-16]; Seaside
Therapeutics, Inc. (Cambridge, MA)
FX This work was supported by the National Institutes of Health National
Institute of Mental Health [Grant 5-R01-MH62646-13]; the National
Institutes of Health National Institute of Neurological Disorders and
Stroke [2-R01-NS31373-16]; and Seaside Therapeutics, Inc. (Cambridge,
MA).
CR Akabane T, 2011, XENOBIOTICA, V41, P372, DOI 10.3109/00498254.2010.549970
Balani SK, 2005, CURR TOP MED CHEM, V5, P1033, DOI 10.2174/156802605774297038
Bear MF, 2004, TRENDS NEUROSCI, V27, P370, DOI 10.1016/j.tins.2004.04.009
Beedham C, 2003, J CLIN PSYCHOPHARM, V23, P229, DOI 10.1097/00004714-200306000-00003
Dalvie D, 2010, DRUG METAB DISPOS, V38, P641, DOI 10.1124/dmd.109.030783
De Montellano PRO, 2005, CYTOCHROME P450 STRU
Deguchi T, 2011, DRUG METAB DISPOS, V39, P820, DOI 10.1124/dmd.110.037457
Diamond S, 2010, DRUG METAB DISPOS, V38, P1277, DOI 10.1124/dmd.110.032375
Dittrich C, 2002, EUR J CANCER, V38, P1072, DOI 10.1016/S0959-8049(02)00020-5
Emmitte KA, 2011, ACS CHEM NEUROSCI, V2, P411, DOI 10.1021/cn2000266
Gabrielsson J, 2000, PHARMACOKINETIC PHAR
Garattini E, 2012, EXPERT OPIN DRUG MET, V8, P487, DOI 10.1517/17425255.2012.663352
Guengerich FP, 2001, CHEM RES TOXICOL, V14, P611, DOI 10.1021/tx0002583
Hosea NA, 2009, J CLIN PHARMACOL, V49, P513, DOI 10.1177/0091270009333209
Houston JB, 2008, CURR DRUG METAB, V9, P940, DOI 10.2174/138920008786485164
Hutzler JM, 2012, DRUG METAB DISPOS, V40, P267, DOI 10.1124/dmd.111.042861
Hutzler JM, 2010, DRUG METAB DISPOS, V38, P1113, DOI 10.1124/dmd.110.032706
JOHNSON C, 1985, BIOCHEM PHARMACOL, V34, P4251, DOI 10.1016/0006-2952(85)90280-1
Jones CK, 2011, CURR NEUROPHARMACOL, V9, P31
Klecker RW, 2006, BIOORGAN MED CHEM, V14, P62, DOI 10.1016/j.bmc.2005.07.053
Lake BG, 2002, XENOBIOTICA, V32, P835, DOI 10.1080/00498250210158915
Liu LC, 2011, DRUG METAB DISPOS, V39, P1840, DOI 10.1124/dmd.111.040840
Niswender CM, 2010, ANNU REV PHARMACOL, V50, P295, DOI 10.1146/annurev.pharmtox.011008.145533
Obach RS, 2002, DRUG METAB DISPOS, V30, P831, DOI 10.1124/dmd.30.7.831
Obach RS, 2004, J CLIN PHARMACOL, V44, P7, DOI 10.1177/0091270003260336
Obach RS, 2004, DRUG METAB DISPOS, V32, P89, DOI 10.1124/dmd.32.1.89
Obach RS, 1997, J PHARMACOL EXP THER, V283, P46
Pryde DC, 2010, J MED CHEM, V53, P8441, DOI 10.1021/jm100888d
Rashidi MR, 1997, DRUG METAB DISPOS, V25, P805
Sahi Jasminder, 2008, Drug Metab Lett, V2, P176, DOI 10.2174/187231208785425818
Sharma R, 2011, CHEM RES TOXICOL, V24, P2207, DOI 10.1021/tx200329k
Smith DA, 2009, CHEM RES TOXICOL, V22, P267, DOI 10.1021/tx800415j
Zientek M, 2010, DRUG METAB DISPOS, V38, P1322, DOI 10.1124/dmd.110.033555
NR 33
TC 14
Z9 14
PU AMER SOC PHARMACOLOGY EXPERIMENTAL THERAPEUTICS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3995 USA
SN 0090-9556
J9 DRUG METAB DISPOS
JI Drug Metab. Dispos.
PD SEP
PY 2012
VL 40
IS 9
BP 1834
EP 1845
DI 10.1124/dmd.112.046136
PG 12
WC Pharmacology & Pharmacy
SC Pharmacology & Pharmacy
GA 996EX
UT WOS:000308068500022
PM 22711749
ER
PT J
AU Moldrich, R
Leanage, G
Reutens, D
AF Moldrich, R.
Leanage, G.
Reutens, D.
TI HOW SODIUM VALPROATE CAUSES LANGUAGE DELAY AND AUTISM - A MOLECULAR
STUDY
SO EPILEPSIA
LA English
DT Meeting Abstract
CT 10th European Congress on Epileptology
CY SEP 30-OCT 04, 2012
CL London, ENGLAND
C1 [Moldrich, R.; Leanage, G.; Reutens, D.] Univ Queensland, Brisbane, Qld, Australia.
NR 0
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0013-9580
J9 EPILEPSIA
JI Epilepsia
PD SEP
PY 2012
VL 53
SU 5
SI SI
BP 5
EP 6
PG 2
WC Clinical Neurology
SC Neurosciences & Neurology
GA 007GD
UT WOS:000308875900016
ER
PT J
AU Lesca, G
Rudolf, G
Labalme, A
Hirsch, E
Arzimanoglou, A
Genton, P
Motte, J
De Saint Martin, A
Valenti, M
Boulay, C
De Bellescize, J
Keo-Kosal, P
Boutry-Kryza, N
Edery, P
Sanlaville, D
Szepetowski, P
AF Lesca, G.
Rudolf, G.
Labalme, A.
Hirsch, E.
Arzimanoglou, A.
Genton, P.
Motte, J.
De Saint Martin, A.
Valenti, M.
Boulay, C.
De Bellescize, J.
Keo-Kosal, P.
Boutry-Kryza, N.
Edery, P.
Sanlaville, D.
Szepetowski, P.
TI EPILEPTIC ENCEPHALOPATHIES OF THE LANDAU-KLEFFNER AND CONTINUOUS SPIKE
AND WAVES DURING SLOW-WAVE SLEEP TYPES: GENOMIC DISSECTION MAKES THE
LINK WITH AUTISM
SO EPILEPSIA
LA English
DT Meeting Abstract
CT 10th European Congress on Epileptology
CY SEP 30-OCT 04, 2012
CL London, ENGLAND
C1 [Lesca, G.; Arzimanoglou, A.; Edery, P.; Sanlaville, D.] CRNL, CNRS UMR 5292, INSERM U1028, Lyon, France.
[Rudolf, G.; Hirsch, E.; De Saint Martin, A.; Valenti, M.; Boulay, C.] Strasbourg Univ Hosp, Strasbourg, France.
[Labalme, A.] Univ Hosp Lyon, Bron, France.
[Genton, P.] Henri Gastaut Hosp, Marseille, France.
[Motte, J.] Reims Univ Hosp, Amer Mem Hosp, Reims, France.
[De Bellescize, J.; Keo-Kosal, P.] Epilepsy Sleep & Pediat Neurophysiol Dpt, Lyon, France.
[Boutry-Kryza, N.] Univ Lyon 1, Lyon Univ Hosp, F-69365 Lyon, France.
[Szepetowski, P.] Mediterranean Inst Neurobiol INMED, Marseille, France.
RI sanlaville, damien/M-4716-2014
OI sanlaville, damien/0000-0001-9939-2849
NR 0
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0013-9580
J9 EPILEPSIA
JI Epilepsia
PD SEP
PY 2012
VL 53
SU 5
SI SI
BP 92
EP 93
PG 2
WC Clinical Neurology
SC Neurosciences & Neurology
GA 007GD
UT WOS:000308875900316
ER
PT J
AU Oberman, L
Eldaief, M
Fecteau, S
Ifert-Miller, F
Tormos, JM
Pascual-Leone, A
AF Oberman, Lindsay
Eldaief, Mark
Fecteau, Shirley
Ifert-Miller, Fritz
Maria Tormos, Jose
Pascual-Leone, Alvaro
TI Abnormal modulation of corticospinal excitability in adults with
Asperger's syndrome
SO EUROPEAN JOURNAL OF NEUROSCIENCE
LA English
DT Article
DE autism spectrum disorders; plasticity; theta burst stimulation;
transcranial magnetic stimulation
ID TRANSCRANIAL MAGNETIC STIMULATION; THETA-BURST-STIMULATION; AUTISM
SPECTRUM DISORDER; HUMAN MOTOR CORTEX; FRAGILE-X-SYNDROME; LANGUAGE
DISORDER; POSTURAL CONTROL; CHILDREN; PLASTICITY; PREVALENCE
AB Most candidate genes and genetic abnormalities linked to autism spectrum disorders (ASD) are thought to play a role in developmental and experience-dependent plasticity. As a possible index of plasticity, we assessed the modulation of motor corticospinal excitability in individuals with Aspergers syndrome (AS) using transcranial magnetic stimulation (TMS). We measured the modulatory effects of theta-burst stimulation (TBS) on motor evoked potentials (MEPs) induced by single-pulse TMS in individuals with AS as compared with age-, gender- and IQ-matched neurotypical controls. The effect of TBS lasted significantly longer in the AS group. The duration of the TBS-induced modulation alone enabled the reliable classification of a second study cohort of subjects as AS or neurotypical. The alteration in the modulation of corticospinal excitability in AS is thought to reflect aberrant mechanisms of plasticity, and might provide a valuable future diagnostic biomarker for the disease and ultimately offer a target for novel therapeutic interventions.
C1 [Oberman, Lindsay; Eldaief, Mark; Fecteau, Shirley; Ifert-Miller, Fritz; Pascual-Leone, Alvaro] Beth Israel Deaconess Med Ctr, Dept Neurol, Berenson Allen Ctr Noninvas Brain Stimulat, Boston, MA 02215 USA.
[Oberman, Lindsay; Eldaief, Mark; Fecteau, Shirley; Ifert-Miller, Fritz; Pascual-Leone, Alvaro] Harvard Univ, Sch Med, Boston, MA USA.
[Fecteau, Shirley] Univ Laval, Fac Med, Dept Rehabil, Quebec City, PQ G1K 7P4, Canada.
[Maria Tormos, Jose; Pascual-Leone, Alvaro] Univ Autonoma Barcelona, Inst Univ Neurorehabil Guttmann, Badalona, Spain.
[Pascual-Leone, Alvaro] Beth Israel Deaconess Med Ctr, Harvard Thorndike Clin Res Ctr, Boston, MA 02215 USA.
RP Pascual-Leone, A (reprint author), Beth Israel Deaconess Med Ctr, Dept Neurol, Berenson Allen Ctr Noninvas Brain Stimulat, Boston, MA 02215 USA.
EM apleone@bidmc.harvard.edu
FU National Center for Research Resources: Harvard-Thorndike Clinical
Research Center at BIDMC [NCRR MO1 RR01032]; National Center for
Research Resources: Harvard Clinical and Translational Science Center
[UL1 RR025758]; NIH [K24 RR018875, F32MH080493]; Autism Speaks; Nancy
Lurie Marks Family Foundation
FX Work on this study was supported by grants from the National Center for
Research Resources: Harvard-Thorndike Clinical Research Center at BIDMC
(NCRR MO1 RR01032) and Harvard Clinical and Translational Science Center
(UL1 RR025758); NIH grant K24 RR018875 and a grants from Autism Speaks
and the Nancy Lurie Marks Family Foundation to A.P.-L. L. Oberman was
supported by NIH fellowship F32MH080493. We thank Paul Wang, Joseph
Gonzalez-Heydrich, Alexander Rotenberg, Jonathan Picker, Albert
Galaburda, Mike Greenberg, Christopher Walsh, Shiva Gautam, Murray
Mittleman and Carla Shatz for valuable comments on the data and the
manuscript and the Boston Autism Consortium for their help with
recruitment. The content of this manuscript is solely the responsibility
of the authors and does not necessarily represent the official views of
the Nancy Lurie Marks Family Foundation, National Center for Research
Resources or the National Institutes of Health.
CR Baird G, 2006, LANCET, V368, P210, DOI 10.1016/S0140-6736(06)69041-7
Baron-Cohen S, 2009, BRIT J PSYCHIAT, V194, P500, DOI 10.1192/bjp.bp.108.059345
Bassell GJ, 2008, NEURON, V60, P201, DOI 10.1016/j.neuron.2008.10.004
Belmonte MK, 2004, J NEUROSCI, V24, P9228, DOI 10.1523/JNEUROSCI.3340-04.2004
Courchesne E, 2001, NEUROLOGY, V57, P245
Di Lazzaro V, 2011, J NEUROPHYSIOL, V105, P2150, DOI 10.1152/jn.00781.2010
Dolen G, 2009, J NEURODEV DISORD, V1, P133, DOI 10.1007/s11689-009-9015-x
Fatemi SH, 2010, J AUTISM DEV DISORD, V40, P743, DOI 10.1007/s10803-009-0924-z
Fatemi SH, 2009, CEREBELLUM, V8, P64, DOI 10.1007/s12311-008-0075-3
Fatemi SH, 2011, ANAT REC, V294, P1635, DOI 10.1002/ar.21299
Fatemi SH, 2009, J AUTISM DEV DISORD, V39, P223, DOI 10.1007/s10803-008-0646-7
Fitzgerald PB, 2006, CLIN NEUROPHYSIOL, V117, P2584, DOI 10.1016/j.clinph.2006.06.712
Geschwind DH, 2007, CURR OPIN NEUROBIOL, V17, P103, DOI 10.1016/j.conb.2007.01.009
Ghaziuddin M, 1998, J INTELL DISABIL RES, V42, P43, DOI 10.1046/j.1365-2788.1998.00065.x
Gogolla N, 2009, J NEURODEV DISORD, V1, P172, DOI 10.1007/s11689-009-9023-x
Herbert MR, 2004, ANN NEUROL, V55, P530, DOI 10.1002/ana.20032
Hoogendam JM, 2010, BRAIN STIMUL, V3, P95, DOI 10.1016/j.brs.2009.10.005
Huang YZ, 2005, NEURON, V45, P201, DOI 10.1016/j.neuron.2004.12.033
Huang YZ, 2007, CLIN NEUROPHYSIOL, V118, P1028, DOI 10.1016/j.clinph.2007.01.021
Huerta PT, 2009, J NEUROENG REHABIL, V6, DOI 10.1186/1743-0003-6-7
Ives JR, 2006, CLIN NEUROPHYSIOL, V117, P1870, DOI 10.1016/j.clinph.2006.04.010
Kleim JA, 2006, NAT NEUROSCI, V9, P735, DOI 10.1038/nn1699
Kobayashi M, 2003, LANCET NEUROL, V2, P145, DOI 10.1016/S1474-4422(03)00321-1
KOHENRAZ R, 1992, J AUTISM DEV DISORD, V22, P419, DOI 10.1007/BF01048244
Lu B, 2003, LEARN MEMORY, V10, P86, DOI 10.1101/lm.54603
Mari M, 2003, PHILOS T ROY SOC B, V358, P393, DOI 10.1098/rstb.2002.1205
Markram Henry, 2007, Front Neurosci, V1, P77, DOI 10.3389/neuro.01.1.1.006.2007
Minshew NJ, 2004, NEUROLOGY, V63, P2056
Miyahara M, 1997, J AUTISM DEV DISORD, V27, P595, DOI 10.1023/A:1025834211548
Morrow EM, 2008, SCIENCE, V321, P218, DOI 10.1126/science.1157657
Noterdaeme M, 2002, EUR CHILD ADOLES PSY, V11, P219, DOI 10.1007/s00787-002-0285-z
Oberman L, 2008, BEHAV BRAIN SCI, V31, P241
Pascual-Leone A, 2011, BRAIN TOPOGR, V24, P302, DOI 10.1007/s10548-011-0196-8
Rinaldi T, 2007, P NATL ACAD SCI USA, V104, P13501, DOI 10.1073/pnas.0704391104
Rossi S, 2009, CLIN NEUROPHYSIOL, V120, P2008, DOI 10.1016/j.clinph.2009.08.016
Rubenstein JLR, 2003, GENES BRAIN BEHAV, V2, P255, DOI 10.1046/j.1601-183X.2003.00037.x
Stagg CJ, 2009, J NEUROPHYSIOL, V101, P2872, DOI 10.1152/jn.91060.2008
Teitelbaum P, 1998, P NATL ACAD SCI USA, V95, P13982, DOI 10.1073/pnas.95.23.13982
Theoret H, 2005, CURR BIOL, V15, pR84, DOI 10.1016/j.cub.2005.01.022
Thut G, 2010, BRAIN TOPOGR, V22, P219, DOI 10.1007/s10548-009-0115-4
Thut G, 2010, BRAIN TOPOGR, V22, P215, DOI 10.1007/s10548-009-0128-z
Thut G, 2005, J NEUROSCI METH, V141, P207, DOI 10.1016/j.jneumeth.2004.06.016
Tordjman S, 2007, BEHAV GENET, V37, P61, DOI 10.1007/s10519-006-9120-5
Tsai SJ, 2005, MED HYPOTHESES, V65, P79, DOI 10.1016/j.mehy.2005.01.034
Ziemann U, 2008, BRAIN STIMUL, V1, P164, DOI 10.1016/j.brs.2008.06.006
NR 45
TC 11
Z9 11
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0953-816X
J9 EUR J NEUROSCI
JI Eur. J. Neurosci.
PD SEP
PY 2012
VL 36
IS 6
BP 2782
EP 2788
DI 10.1111/j.1460-9568.2012.08172.x
PG 7
WC Neurosciences
SC Neurosciences & Neurology
GA 008EU
UT WOS:000308941000007
PM 22738084
ER
PT J
AU Ruthsatz, J
Urbach, JB
AF Ruthsatz, Joanne
Urbach, Jourdan B.
TI Child prodigy: A novel cognitive profile places elevated general
intelligence, exceptional working memory and attention to detail at the
root of prodigiousness
SO INTELLIGENCE
LA English
DT Article
DE Child prodigy; Working memory; General intelligence; Attention to
detail; Autism
ID SPECTRUM; AUTISM; AQ
AB Child prodigies are unusual for their early and exceptional adoption of what are traditionally thought of as adult abilities. As part of an effort to better understand the underpinnings of these extraordinary individuals' talent, the researcher examined the cognitive and developmental profiles of eight child prodigies by taking their developmental histories and administering the Stanford-Binet 5th ed. full scale intelligence test and the Autism-Spectrum Quotient (AQ). The collected data reveals a startling picture. While each of the prodigies demonstrated an at least moderately elevated level of intelligence, the prodigies' full scale IQ scores were not consistently on the extreme end of the spectrum. What was consistently extraordinary, however, was the child prodigies' working memory scores-a category in which every prodigy tested in the 99th percentile. Additional results suggest a previously unknown connection between child prodigies and autism. The prodigies' family histories yielded an unlikely number of autistic relatives. And the child prodigies received elevated AQ scores with respect to attention to detail, a trait associated with autism. The prodigies did not, however, display many of the other traits typically associated with autism. This result raises the possibility of a moderated autism that actually enables the prodigies' extraordinary talent. (C) 2012 Elsevier Inc. All rights reserved.
C1 [Ruthsatz, Joanne] Ohio State Univ, Columbus, OH 43210 USA.
[Urbach, Jourdan B.] Yale Univ, New Haven, CT 06520 USA.
RP Ruthsatz, J (reprint author), Ohio State Univ, Columbus, OH 43210 USA.
EM ruthsatz.4@osu.edu
CR Baron-Cohen S, 2009, PHILOS T R SOC B, V364, P1377, DOI 10.1098/rstb.2008.0337
Baron-Cohen S, 2001, J AUTISM DEV DISORD, V31, P5, DOI 10.1023/A:1005653411471
Detterman DK, 1999, J EDUC GIFTED, V22, P148
ERICSSON KA, 1993, PSYCHOL REV, V100, P363, DOI 10.1037/0033-295X.100.3.363
Ericsson K. A., 1996, ROAD EXCELLENCE ACQU
Feldman D., 2011, CAMBRIDGE HDB INTELL, P210
Howe M. J. A., 1990, ORIGINS EXCEPTIONAL
Nettelbeck T, 1996, INTELLIGENCE, V22, P49, DOI 10.1016/S0160-2896(96)90020-3
REVESZ G., 1925, PSYCHOL MUSICAL PROD
Roid G. H., 2003, STANFORD BINET INTEL
Ruthsatz J, 2003, INTELLIGENCE, V31, P509, DOI 10.1016/S0160-2896(03)00050-3
Ruthsatz J, 2007, BEHAV GENET, V37, P790
This H, 2006, EMBO REP, V7, P1062, DOI 10.1038/sj.embor.7400850
Treffert D. A., 2010, ISLANDS GENIUS
Vandervert LR, 2009, J MIND BEHAV, V30, P15
Woodbury-Smith MR, 2005, J AUTISM DEV DISORD, V35, P331, DOI 10.1007/s10803-005-3300-7
NR 16
TC 8
Z9 8
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0160-2896
J9 INTELLIGENCE
JI Intelligence
PD SEP-OCT
PY 2012
VL 40
IS 5
BP 419
EP 426
DI 10.1016/j.intell.2012.06.002
PG 8
WC Psychology, Multidisciplinary
SC Psychology
GA 010GV
UT WOS:000309083800006
ER
PT J
AU Jemel, B
Mimeault, D
Saint-Amour, D
Mottron, L
AF Jemel, B.
Mimeault, D.
Saint-Amour, D.
Mottron, L.
TI VEP contrast sensitivity responses reveal reduced functional segregation
of visual processing channels in autism
SO INTERNATIONAL JOURNAL OF PSYCHOPHYSIOLOGY
LA English
DT Meeting Abstract
CT 16th World Congress of Psychophysiology of the International
Organization of Psychophysiology (IOP)
CY SEP 13-17, 2012
CL Pisa, ITALY
SP Int Org Psychophysiol (IOP)
C1 [Jemel, B.; Mimeault, D.; Mottron, L.] Hop Riviere Prairies, Montreal, PQ, Canada.
[Jemel, B.; Mottron, L.] Univ Montreal, Montreal, PQ, Canada.
[Saint-Amour, D.] CHU St Justine Res Ctr, Montreal, PQ, Canada.
NR 0
TC 0
Z9 0
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0167-8760
J9 INT J PSYCHOPHYSIOL
JI Int. J. Psychophysiol.
PD SEP
PY 2012
VL 85
IS 3
SI SI
BP 298
EP 298
DI 10.1016/j.ijpsycho.2012.06.026
PG 1
WC Psychology, Biological; Neurosciences; Physiology; Psychology;
Psychology, Experimental
SC Psychology; Neurosciences & Neurology; Physiology
GA 005XV
UT WOS:000308784300028
ER
PT J
AU Pei, F
Baldassi, S
Norcia, A
AF Pei, F.
Baldassi, S.
Norcia, A.
TI Visual gain control abnormalities in Autism Spectrum Disorders
SO INTERNATIONAL JOURNAL OF PSYCHOPHYSIOLOGY
LA English
DT Meeting Abstract
CT 16th World Congress of Psychophysiology of the International
Organization of Psychophysiology (IOP)
CY SEP 13-17, 2012
CL Pisa, ITALY
SP Int Org Psychophysiol (IOP)
C1 [Pei, F.; Baldassi, S.; Norcia, A.] Stanford Univ, Dept Psychol, Stanford, CA 94305 USA.
[Baldassi, S.] Univ Florence, Dept Psychol, Florence, Italy.
NR 0
TC 0
Z9 0
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0167-8760
J9 INT J PSYCHOPHYSIOL
JI Int. J. Psychophysiol.
PD SEP
PY 2012
VL 85
IS 3
SI SI
BP 298
EP 299
DI 10.1016/j.ijpsycho.2012.06.027
PG 2
WC Psychology, Biological; Neurosciences; Physiology; Psychology;
Psychology, Experimental
SC Psychology; Neurosciences & Neurology; Physiology
GA 005XV
UT WOS:000308784300029
ER
PT J
AU Clery, H
Bruneau, N
Roux, S
Houy-Durand, E
Bonnet-Brilhault, F
Gomot, M
AF Clery, H.
Bruneau, N.
Roux, S.
Houy-Durand, E.
Bonnet-Brilhault, F.
Gomot, M.
TI Automatic visual change perception through typical development and in
autism: An electrophysiological study
SO INTERNATIONAL JOURNAL OF PSYCHOPHYSIOLOGY
LA English
DT Meeting Abstract
CT 16th World Congress of Psychophysiology of the International
Organization of Psychophysiology (IOP)
CY SEP 13-17, 2012
CL Pisa, ITALY
SP Int Org Psychophysiol (IOP)
C1 [Clery, H.; Bruneau, N.; Roux, S.; Bonnet-Brilhault, F.; Gomot, M.] Univ Tours, CHRU Tours, INSERM, U930,UMR, F-37041 Tours, France.
[Houy-Durand, E.] CHRU Tours, Ctr Ressources Autisme, Tours, France.
NR 0
TC 0
Z9 0
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0167-8760
J9 INT J PSYCHOPHYSIOL
JI Int. J. Psychophysiol.
PD SEP
PY 2012
VL 85
IS 3
SI SI
BP 299
EP 299
DI 10.1016/j.ijpsycho.2012.06.028
PG 1
WC Psychology, Biological; Neurosciences; Physiology; Psychology;
Psychology, Experimental
SC Psychology; Neurosciences & Neurology; Physiology
GA 005XV
UT WOS:000308784300030
ER
PT J
AU Lazarev, VV
Pontes, A
deAzevedo, LC
AF Lazarev, V. V.
Pontes, A.
deAzevedo, L. C.
TI Latent alterations in intra- and interhemispheric functional
connectivities in childhood autism detected by EEG photic driving
coherence
SO INTERNATIONAL JOURNAL OF PSYCHOPHYSIOLOGY
LA English
DT Meeting Abstract
CT 16th World Congress of Psychophysiology of the International
Organization of Psychophysiology (IOP)
CY SEP 13-17, 2012
CL Pisa, ITALY
SP Int Org Psychophysiol (IOP)
C1 [Lazarev, V. V.; Pontes, A.; deAzevedo, L. C.] Fundacao Oswaldo Cruz, Fernandes Figueira Inst, Rio De Janeiro, Brazil.
NR 0
TC 0
Z9 0
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0167-8760
J9 INT J PSYCHOPHYSIOL
JI Int. J. Psychophysiol.
PD SEP
PY 2012
VL 85
IS 3
SI SI
BP 299
EP 299
DI 10.1016/j.ijpsycho.2012.06.029
PG 1
WC Psychology, Biological; Neurosciences; Physiology; Psychology;
Psychology, Experimental
SC Psychology; Neurosciences & Neurology; Physiology
GA 005XV
UT WOS:000308784300031
ER
PT J
AU Watson, LR
Roberts, JE
Baranek, GT
Yoder, P
AF Watson, L. R.
Roberts, J. E.
Baranek, G. T.
Yoder, P.
TI Respiratory sinus arrhythmia as a predictor of language outcomes in
children with autism
SO INTERNATIONAL JOURNAL OF PSYCHOPHYSIOLOGY
LA English
DT Meeting Abstract
CT 16th World Congress of Psychophysiology of the International
Organization of Psychophysiology (IOP)
CY SEP 13-17, 2012
CL Pisa, ITALY
SP Int Org Psychophysiol (IOP)
C1 [Watson, L. R.; Baranek, G. T.] Univ N Carolina, Chapel Hill, NC USA.
[Roberts, J. E.] Univ S Carolina, Columbia, SC 29208 USA.
[Yoder, P.] Vanderbilt Univ, Nashville, TN 37235 USA.
NR 0
TC 0
Z9 0
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0167-8760
J9 INT J PSYCHOPHYSIOL
JI Int. J. Psychophysiol.
PD SEP
PY 2012
VL 85
IS 3
SI SI
BP 348
EP 348
DI 10.1016/j.ijpsycho.2012.06.154
PG 1
WC Psychology, Biological; Neurosciences; Physiology; Psychology;
Psychology, Experimental
SC Psychology; Neurosciences & Neurology; Physiology
GA 005XV
UT WOS:000308784300153
ER
PT J
AU Levine, T
AF Levine, T.
TI Physiologic arousal to social stress in children with autism spectrum
disorders
SO INTERNATIONAL JOURNAL OF PSYCHOPHYSIOLOGY
LA English
DT Meeting Abstract
CT 16th World Congress of Psychophysiology of the International
Organization of Psychophysiology (IOP)
CY SEP 13-17, 2012
CL Pisa, ITALY
SP Int Org Psychophysiol (IOP)
C1 [Levine, T.] Brown Univ, Brown Ctr Study Children Risk, Warren Alpert Med Sch, Providence, RI 02912 USA.
NR 0
TC 0
Z9 0
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0167-8760
J9 INT J PSYCHOPHYSIOL
JI Int. J. Psychophysiol.
PD SEP
PY 2012
VL 85
IS 3
SI SI
BP 349
EP 349
DI 10.1016/j.ijpsycho.2012.06.156
PG 1
WC Psychology, Biological; Neurosciences; Physiology; Psychology;
Psychology, Experimental
SC Psychology; Neurosciences & Neurology; Physiology
GA 005XV
UT WOS:000308784300155
ER
PT J
AU Martineau, J
Hernandez, N
Roche, L
Bonnet-Brilhault, F
AF Martineau, J.
Hernandez, N.
Roche, L.
Bonnet-Brilhault, F.
TI Pupil size and pupil reactivity to faces in children with autism
spectrum disorders
SO INTERNATIONAL JOURNAL OF PSYCHOPHYSIOLOGY
LA English
DT Meeting Abstract
CT 16th World Congress of Psychophysiology of the International
Organization of Psychophysiology (IOP)
CY SEP 13-17, 2012
CL Pisa, ITALY
SP Int Org Psychophysiol (IOP)
C1 [Martineau, J.; Hernandez, N.; Roche, L.; Bonnet-Brilhault, F.] Univ Tours, CHRU Tours, UMR INSERM U930, Tours, France.
NR 0
TC 0
Z9 0
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0167-8760
J9 INT J PSYCHOPHYSIOL
JI Int. J. Psychophysiol.
PD SEP
PY 2012
VL 85
IS 3
SI SI
BP 349
EP 349
DI 10.1016/j.ijpsycho.2012.06.157
PG 1
WC Psychology, Biological; Neurosciences; Physiology; Psychology;
Psychology, Experimental
SC Psychology; Neurosciences & Neurology; Physiology
GA 005XV
UT WOS:000308784300156
ER
PT J
AU Lawrence, EJ
Dumigan, R
Schoenberg, P
Mauricio, S
Murphy, DG
David, AS
AF Lawrence, Emma Jane
Dumigan, Rachael
Schoenberg, Poppy
Mauricio, Sierra
Murphy, Declan G.
David, Anthony S.
TI Conditional Reasoning in Asperger's Syndrome and Depersonalization
Disorder
SO JOURNAL OF NERVOUS AND MENTAL DISEASE
LA English
DT Article
DE Asperger's syndrome; depersonalization; reasoning; emotion; logic
ID AUTONOMIC RESPONSE; AUTISM; BEHAVIOR; EMOTION; LOGIC
AB Conditional reasoning premises can be systematically manipulated to elicit specific response patterns. This is useful for investigating the reasoning style of people who report clinical symptoms. We administered a standardized conditional reasoning task to 16 participants with a diagnosis of Asperger's syndrome (AS), 16 participants with a diagnosis of depersonalization disorder (DPD), and 32 intelligence-quotient-matched controls. Premises were manipulated for a) context, with some being embedded within extra statements, and b) content, neutral or emotional. Both the AS and DPD participants were less likely to incorporate exceptions to the given premises than the controls, indicating difficulties with mental flexibility, although this effect was less marked in the DPD group. It seems the AS participants were also less influenced than the controls by statements that highlight possible alternative consequences. However, this effect was less robust than that observed with statements detailing exceptions, suggesting it may be because of general problems with executive function rather than difficulties in processing contextual information. We did not observe the expected difference between the DPD participants and the controls when reasoning with emotional premises. Overall, these data suggest that the DPD and AS participants have distinct reasoning styles, which may be of use for interventions based on cognitive change.
C1 [Lawrence, Emma Jane; Dumigan, Rachael; Schoenberg, Poppy; Mauricio, Sierra; Murphy, Declan G.; David, Anthony S.] Kings Coll London, Inst Psychiat, London SE5 8AF, England.
RP Lawrence, EJ (reprint author), Kings Coll London, Inst Psychiat, POB 68,De Crespigny Pk, London SE5 8AF, England.
EM emma.lawrence@kcl.ac.uk
RI David, Anthony/C-1315-2011
OI David, Anthony/0000-0003-0967-774X
CR American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th
Anderson S, 2006, BEHAV COGN PSYCHOTH, V34, P293, DOI 10.1017/S1352465805002651
Blair J, 1999, PERS INDIV DIFFER, V26, P477
Blanchette I, 2010, EXP PSYCHOL, V58, P235
Blanchette I, 2004, PSYCHOL SCI, V15, P745, DOI 10.1111/j.0956-7976.2004.00751.x
Blanchette I, 2006, MEM COGNITION, V34, P1112, DOI 10.3758/BF03193257
BYRNE RMJ, 1989, COGNITION, V31, P61, DOI 10.1016/0010-0277(89)90018-8
Carlson E, 1991, FACTOR ANAL DISSOCIA
Guralnik O, 2000, AM J PSYCHIAT, V157, P103
Happe F, 2006, J AUTISM DEV DISORD, V36, P5, DOI 10.1007/s10803-005-0039-0
Hill EL, 2004, TRENDS COGN SCI, V8, P26, DOI 10.1016/j.tics.2003.11.003
Kemp R, 1997, BRIT J PSYCHIAT, V170, P398, DOI 10.1192/bjp.170.5.398
Lawrence E, 2004, J NERV MENT DIS, V192, P727, DOI 10.1097/01.nmd.0000144691.22135.d0
LORD C, 1989, J AUTISM DEV DISORD, V19, P185, DOI 10.1007/BF02211841
LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
McKenzie R, 2010, DEV PSYCHOL, V46, P391, DOI 10.1037/a0017412
Nelson H. E., 1982, NATL ADULT READING T
Pijnacker J, 2009, NEUROPSYCHOLOGIA, V47, P644, DOI 10.1016/j.neuropsychologia.2008.11.011
Shalom B, 2003, ANN NY ACAD SCI, V985, P501
Sierra M, 2006, PSYCHIAT RES, V145, P225, DOI 10.1016/j.psychres.2005.05.022
Sierra M, 2005, PSYCHOL MED, V35, P1523, DOI 10.1017/S0033291705005325
Sierra M, 2002, ARCH GEN PSYCHIAT, V59, P833, DOI 10.1001/archpsyc.59.9.833
Simeon D, 2008, PSYCHIAT RES, V157, P303, DOI 10.1016/j.psychres.2007.07.007
Simeon D, 1998, J NERV MENT DIS, V186, P536, DOI 10.1097/00005053-199809000-00004
Wing J.K., 1974, MEASUREMENT CLASSIFI
NR 25
TC 1
Z9 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0022-3018
J9 J NERV MENT DIS
JI J. Nerv. Ment. Dis.
PD SEP
PY 2012
VL 200
IS 9
BP 796
EP 800
DI 10.1097/NMD.0b013e318266ba2b
PG 5
WC Clinical Neurology; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA 003KX
UT WOS:000308611500011
PM 22922241
ER
PT J
AU Davis, RE
Williams, M
AF Davis, Robert E.
Williams, Michael
TI Mitochondrial Function and Dysfunction: An Update
SO JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
LA English
DT Article
ID ELECTRON-TRANSPORT CHAIN; AMYOTROPHIC-LATERAL-SCLEROSIS; PERMEABILITY
TRANSITION PORE; ALZHEIMERS-DISEASE; AMYLOID-BETA;
CARDIOVASCULAR-DISEASE; PHARMACOLOGICAL TARGET; PROTEIN-PRECURSOR;
OXIDATIVE STRESS; CYTOCHROME-C
AB With the current explosion of knowledge on the role of mitochondrial dysfunction in the genesis of various human disease states, there is an increased interest in targeting mitochondrial processes, pathways, and proteins for drug discovery efforts in cancer and cardiovascular, metabolic, and central nervous system diseases, the latter including autism and neurodegenerative diseases. We provide an update on understanding the central role of the mitochondrion in ATP and reactive oxygen species production and in controlling cell death pathways.
C1 [Williams, Michael] Northwestern Univ, Feinberg Sch Med, Dept Mol Pharmacol & Biol Chem, Chicago, IL 60611 USA.
[Davis, Robert E.] 3D Pharmaceut Consultants, La Jolla, CA USA.
RP Williams, M (reprint author), Northwestern Univ, Feinberg Sch Med, Dept Mol Pharmacol & Biol Chem, Chicago, IL 60611 USA.
EM rivoli1635@comcast.net
CR Akar FG, 2011, PHARMACOL THERAPEUT, V131, P287, DOI 10.1016/j.pharmthera.2011.04.005
Austin S, 2011, FREE RADICAL BIO MED, V51, P2243, DOI 10.1016/j.freeradbiomed.2011.08.036
Azzolin L, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0016280
Baines CP, 2010, FRONT PHYSIOL, V1, DOI 10.3389/fphys.2010.00156
Ballinger SW, 2005, FREE RADICAL BIO MED, V38, P1278, DOI 10.1016/j.freeradbiomed.2005.02.014
Bertram R, 2006, J THEOR BIOL, V243, P575, DOI 10.1016/j.jtbi.2006.07.019
Biemont C, 2010, GENETICS, V186, P1085, DOI 10.1534/genetics.110.124180
Bordet T., 2010, PHARMACEUTICALS, V3, P345, DOI 10.3390/ph3020345
Bouitbir J., 2011, EUR HEART J, V33, P1397, DOI DOI 10.1093/EURHEARTJ/EHR224
Castellani RJ, 2009, J ALZHEIMERS DIS, V18, P447, DOI 10.3233/JAD-2009-1151
Chan DC, 2006, ANNU REV CELL DEV BI, V22, P79, DOI 10.1146/annurev.cellbio.22.010305.104638
Cooper O, 2012, SCI TRANSL MED, V4, DOI 10.1126/scitranslmed.3003985
Copeland WC, 2008, ANNU REV MED, V59, P131, DOI 10.1146/annurev.med.59.053006.104646
Couzin-Frankel J, 2011, SCIENCE, V334, P1194, DOI 10.1126/science.334.6060.1194
Cudkowicz M, 2011, NAT MED, V17, P1652, DOI 10.1038/nm.2579
Dagda RK, 2009, MITOCHONDRION, V9, P289, DOI 10.1016/j.mito.2009.06.001
de la Monte SM, 2006, J ALZHEIMERS DIS, V10, P89
De Taboada L, 2011, J ALZHEIMERS DIS, V23, P521, DOI 10.3233/JAD-2010-100894
Doody RS, 2008, LANCET, V372, P207, DOI 10.1016/S0140-6736(08)61074-0
Durazo SA, 2012, MITOCHONDRION, V12, P190, DOI 10.1016/j.mito.2011.11.001
Durieux J, 2011, CELL, V144, P79, DOI 10.1016/j.cell.2010.12.016
Edinger AL, 2004, CURR OPIN CELL BIOL, V16, P663, DOI 10.1016/j.ceb.2004.09.011
Eichner LJ, 2011, MITOCHONDRION, V11, P544, DOI 10.1016/j.mito.2011.03.121
Ferrari LF, 2011, J NEUROSCI, V31, P11404, DOI 10.1523/JNEUROSCI.2223-11.2011
Fink BD, 2012, J PHARMACOL EXP THER, V342, P709, DOI 10.1124/jpet.112.195586
Finsterer J, 2010, EUR J PAEDIATR NEURO, V14, P29, DOI 10.1016/j.ejpn.2009.07.005
Fulda S, 2010, NAT REV DRUG DISCOV, V9, P447, DOI 10.1038/nrd3137
Geser F, 2009, J NEUROL, V256, P1205, DOI 10.1007/s00415-009-5069-7
Gilliam LAA, 2012, J PHARMACOL EXP THER, V342, P631, DOI 10.1124/jpet.112.192146
Giorgi C, 2012, MITOCHONDRION, V12, P77, DOI 10.1016/j.mito.2011.07.004
Haas RH, 2008, MOL GENET METAB, V94, P16, DOI 10.1016/j.ymgme.2007.11.018
Halestrap AP, 2009, J MOL CELL CARDIOL, V46, P821, DOI 10.1016/j.yjmcc.2009.02.021
Halliwell B, 2011, TRENDS PHARMACOL SCI, V32, P125, DOI 10.1016/j.tips.2010.12.002
Huang QA, 2010, APOPTOSIS, V15, P1292, DOI 10.1007/s10495-010-0466-z
Huttemann M, 2011, MITOCHONDRION, V11, P369, DOI 10.1016/j.mito.2011.01.010
Javadov S, 2011, CELL PHYSIOL BIOCHEM, V27, P179, DOI 10.1159/000327943
Johri A, 2012, J PHARMACOL EXP THER, V342, P619, DOI 10.1124/jpet.112.192138
Jones S, 2010, CHEM BIOL, V17, P735, DOI 10.1016/j.chembiol.2010.05.018
Kerr DS, 2010, MOL GENET METAB, V99, P246, DOI 10.1016/j.ymgme.2009.11.005
Kitsis RN, 2010, P NATL ACAD SCI USA, V107, P9031, DOI 10.1073/pnas.1003827107
Koopman WJH, 2012, NEW ENGL J MED, V366, P1132, DOI 10.1056/NEJMra1012478
Kroemer G, 2009, CELL DEATH DIFFER, V16, P3, DOI 10.1038/cdd.2008.150
Kujoth GC, 2005, SCIENCE, V309, P481, DOI 10.1126/science.1112125
Kumar S, 2009, J BIOL CHEM, V284, P14760, DOI 10.1074/jbc.M900925200
Kunji ERS, 2010, BBA-BIOENERGETICS, V1797, P817, DOI 10.1016/j.bbabio.2010.03.023
Lagouge M, 2006, CELL, V127, P1109, DOI 10.1016/j.cell.2006.11.013
Lapointe J, 2010, CELL MOL LIFE SCI, V67, P1, DOI 10.1007/s00018-009-0138-8
Lax NZ, 2011, NEUROSCIENTIST, V17, P645, DOI 10.1177/1073858411385469
Lee JY, 2010, J CELL BIOL, V189, P671, DOI 10.1083/jcb.201001039
Legros F, 2004, J CELL SCI, V117, P2653, DOI 10.1242/jcs.01134
Lustbader JW, 2004, SCIENCE, V304, P448, DOI 10.1126/science.1091230
Maldonado EN, 2012, J PHARMACOL EXP THER, V342, P637, DOI 10.1124/jpet.112.192153
Martin LJ, 2011, J NEUROSCI, V31, P359, DOI 10.1523/JNEUROSCI.2225-10.2011
McBride HM, 2006, CURR BIOL, V16, pR551, DOI 10.1016/j.cub.2006.06.054
Mochel F, 2011, J CLIN INVEST, V121, P493, DOI 10.1172/JCI45691
Moreira PI, 2010, BBA-MOL BASIS DIS, V1802, P2, DOI 10.1016/j.bbadis.2009.10.006
Moreira PI, 2007, J NEUROL SCI, V257, P206, DOI 10.1016/j.jns.2007.01.017
Mullane K, 2012, DRUG DISCOV TODAY, V17, P459, DOI 10.1016/j.drudis.2012.01.004
Naviaux RK, 2012, J PHARMACOL EXP THER, V342, P608, DOI 10.1124/jpet.112.192120
Ong SB, 2010, CARDIOVASC RES, V88, P16, DOI 10.1093/cvr/cvq237
Pamplona R., 2011, J AGING RES
Papadopoulos V, 2006, TRENDS PHARMACOL SCI, V27, P402, DOI 10.1016/j.tips.2006.06.005
Pereira CV, 2012, MITOCHONDRION, V12, P66, DOI 10.1016/j.mito.2011.07.003
Poljsak B, 2011, OXID MED CELL LONGEV, DOI 10.1155/2011/194586
Reddy PH, 2009, CNS SPECTRUMS, V14, P8
Reyes NA, 2010, J CLIN INVEST, V120, P3673, DOI 10.1172/JCI42986
Rodriguez-Enriquez S, 2004, INT J BIOCHEM CELL B, V36, P2463, DOI 10.1016/j.biocel.2004.04.009
Roestenberg P, 2012, MITOCHONDRION, V12, P57, DOI 10.1016/j.mito.2011.06.011
Rossignol DA, 2012, MOL PSYCHIATR, V17, P389, DOI 10.1038/mp.2011.165
Sabbagh MN, 2010, FUTURE NEUROL, V5, P645, DOI 10.2217/fnl.10.53
Sahin E, 2011, NATURE, V470, P359, DOI 10.1038/nature09787
Schapira AHV, 2006, LANCET, V368, P70, DOI 10.1016/S0140-6736(06)68970-8
Schatz G, 2007, ANNU REV BIOCHEM, V76, P673, DOI 10.1146/annurev.biochem.76.060806.091141
Schinzel AC, 2005, P NATL ACAD SCI USA, V102, P12005, DOI 10.1073/pnas.0505294102
Schon EA, 2010, TRENDS MOL MED, V16, P268, DOI 10.1016/j.molmed.2010.04.007
Sheridan C, 2010, MITOCHONDRION, V10, P640, DOI 10.1016/j.mito.2010.08.005
Shoshan-Barmatz V, 2012, MITOCHONDRION, V12, P24, DOI 10.1016/j.mito.2011.04.001
Song WJ, 2011, NAT MED, V17, P377, DOI 10.1038/nm.2313
Stacpoole PW, 2011, MITOCHONDRION, V11, P679, DOI 10.1016/j.mito.2011.05.002
Sun LM, 2012, CELL, V148, P213, DOI 10.1016/j.cell.2011.11.031
Suzuki Y, 2010, PHARMACEUTICALS, V3, P1594
Swerdlow RH, 2009, EXP NEUROL, V218, P308, DOI 10.1016/j.expneurol.2009.01.011
Szendroedi J, 2012, NAT REV ENDOCRINOL, V8, P92, DOI 10.1038/nrendo.2011.138
Szewczyk A, 2002, PHARMACOL REV, V54, P101, DOI 10.1124/pr.54.1.101
Tillement L, 2011, MITOCHONDRION, V11, P13, DOI 10.1016/j.mito.2010.08.009
Varanyuwatana P, 2012, MITOCHONDRION, V12, P120, DOI 10.1016/j.mito.2011.04.006
Wallace DC, 2010, MITOCHONDRION, V10, P12, DOI 10.1016/j.mito.2009.09.006
Wallace DC, 2005, ANNU REV GENET, V39, P359, DOI 10.1146/annurev.genet.39.110304.095751
Wallace DC, 1999, SCIENCE, V283, P1482, DOI 10.1126/science.283.5407.1482
Wang CX, 2009, ANNU REV GENET, V43, P95, DOI 10.1146/annurev-genet-102108-134850
Wang ZG, 2012, CELL, V148, P228, DOI 10.1016/j.cell.2011.11.030
Williams M, 2012, TRANSLATIONAL NEUROSCIENCE: APPLICATIONS IN PSYCHIATRY, NEUROLOGY, AND NEURODEVELOPMENTAL DISORDERS, P129
Witte ME, 2010, MITOCHONDRION, V10, P411, DOI 10.1016/j.mito.2010.05.014
Yao J, 2011, J NEUROSCI, V31, P2313, DOI 10.1523/JNEUROSCI.4717-10.2011
Youle RJ, 2011, NAT REV MOL CELL BIO, V12, P9, DOI 10.1038/nrm3028
Zamzami N, 2005, CELL DEATH DIFFER, V12, P1478, DOI 10.1038/sj.cdd.4401682
Zhang ST, 2010, J ALZHEIMERS DIS, V21, P389, DOI 10.3233/JAD-2010-100174
NR 97
TC 14
Z9 14
PU AMER SOC PHARMACOLOGY EXPERIMENTAL THERAPEUTICS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3995 USA
SN 0022-3565
J9 J PHARMACOL EXP THER
JI J. Pharmacol. Exp. Ther.
PD SEP
PY 2012
VL 342
IS 3
BP 598
EP 607
DI 10.1124/jpet.112.192104
PG 10
WC Pharmacology & Pharmacy
SC Pharmacology & Pharmacy
GA 993SH
UT WOS:000307879400001
PM 22700430
ER
PT J
AU Naviaux, RK
AF Naviaux, Robert K.
TI Oxidative Shielding or Oxidative Stress?
SO JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
LA English
DT Article
ID PREVENTION TRIAL SELECT; VITAMIN-E; INSULIN-RESISTANCE; MARINE
ECOSYSTEMS; PROSTATE-CANCER; SKELETAL-MUSCLE; BETA-CAROTENE;
MITOCHONDRIAL; PROTEIN; OXYGEN
AB In this review I report evidence that the mainstream field of oxidative damage biology has been running fast in the wrong direction for more than 50 years. Reactive oxygen species (ROS) and chronic oxidative changes in membrane lipids and proteins found in many chronic diseases are not the result of accidental damage. Instead, these changes are the result of a highly evolved, stereotyped, and protein-catalyzed "oxidative shielding" response that all eukaryotes adopt when placed in a chemically or microbially hostile environment. The machinery of oxidative shielding evolved from pathways of innate immunity designed to protect the cell from attack and limit the spread of infection. Both oxidative and reductive stress trigger oxidative shielding. In the cases in which it has been studied explicitly, functional and metabolic defects occur in the cell before the increase in ROS and oxidative changes. ROS are the response to disease, not the cause. Therefore, it is not the oxidative changes that should be targeted for therapy, but rather the metabolic conditions that create them. This fresh perspective is relevant to diseases that range from autism, type 1 diabetes, type 2 diabetes, cancer, heart disease, schizophrenia, Parkinson's disease, and Alzheimer disease. Research efforts need to be redirected. Oxidative shielding is protective and is a misguided target for therapy. Identification of the causal chemistry and environmental factors that trigger innate immunity and metabolic memory that initiate and sustain oxidative shielding is paramount for human health.
C1 [Naviaux, Robert K.] Univ Calif San Diego, Sch Med, Mitochondrial & Metab Dis Ctr, Dept Med, San Diego, CA 92103 USA.
[Naviaux, Robert K.] Univ Calif San Diego, Dept Pediat, Sch Med, San Diego, CA 92103 USA.
[Naviaux, Robert K.] Univ Calif San Diego, Dept Pathol, Sch Med, San Diego, CA 92103 USA.
RP Naviaux, RK (reprint author), Univ Calif San Diego, Sch Med, Mitochondrial & Metab Dis Ctr, Dept Med, 214 Dickinson St,Bldg CTF,Rm C102, San Diego, CA 92103 USA.
EM naviaux@ucsd.edu
FU University of California San Diego Christini Fund; Wright Foundation;
Lennox Foundation; Jane Botsford-Johnson Foundation; Hailey's Wish
Foundation
FX R.K.N. is supported by the University of California San Diego Christini
Fund, the Wright Foundation, the Lennox Foundation, the Jane
Botsford-Johnson Foundation, and the Hailey's Wish Foundation.
CR HEINONEN OP, 1994, NEW ENGL J MED, V330, P1029
Attene-Ramos MS, 2005, AM J PHYSIOL-CELL PH, V289, pC1220, DOI 10.1152/ajpcell.00164.2005
Azam F, 2007, NAT REV MICROBIOL, V5, P782, DOI 10.1038/nrmicro1747
Birkenfeld AL, 2011, CELL METAB, V14, P184, DOI 10.1016/j.cmet.2011.06.009
Bolanos JP, 2008, BBA-BIOENERGETICS, V1777, P789, DOI 10.1016/j.bbabio.2008.04.011
BRADLEY DJ, 1992, CELL, V70, P21, DOI 10.1016/0092-8674(92)90530-P
Brinkmann H, 2007, ADV EXP MED BIOL, V607, P20
Buchakjian MR, 2010, NAT REV MOL CELL BIO, V11, P715, DOI 10.1038/nrm2972
Burhans WC, 2009, FREE RADICAL BIO MED, V47, P1282, DOI 10.1016/j.freeradbiomed.2009.05.026
Cabiscol E, 2000, J BIOL CHEM, V275, P27393
Cavalier-Smith T, 2006, PHILOS T R SOC B, V361, P969, DOI 10.1098/rstb.2006.1842
Cooper ME, 2009, PEDIATR DIABETES, V10, P343, DOI [10.1111/j.1399-5448.2008.00491.x, 10.1111/j.1399-5448.2009.00491.x]
Copp SW, 2009, EXP PHYSIOL, V94, P961, DOI 10.1113/expphysiol.2009.048223
Crabtree HG, 1929, BIOCHEM J, V23, P536
Dagenais GR, 2008, DIABETES CARE, V31, P1007, DOI 10.2337/dc07-1868
Diaz RJ, 2008, SCIENCE, V321, P926, DOI 10.1126/science.1156401
DOBZHANS.T, 1973, AM BIOL TEACH, V35, P125, DOI 10.2307/4444260
Dunkley AJ, 2012, DIABETES OBES METAB, V14, P616, DOI 10.1111/j.1463-1326.2012.01571.x
Fisher-Wellman KH, 2012, TRENDS ENDOCRIN MET, V23, P142, DOI 10.1016/j.tem.2011.12.008
Galileo Galilei, 2001, DIALOGUE 2 CHIEF WOR
Galluzzi L, 2008, PLOS PATHOG, V4, DOI 10.1371/journal.ppat.1000018
Gille L, 2000, ARCH BIOCHEM BIOPHYS, V375, P347, DOI 10.1006/abbi.1999.1649
Gnaiger E, 1995, J BIOENERG BIOMEMBR, V27, P583, DOI 10.1007/BF02111656
Go Young-Mi, 2008, Biochim Biophys Acta, V1780, P1273, DOI 10.1016/j.bbagen.2008.01.011
Go YM, 2011, FREE RADICAL BIO MED, V50, P495, DOI 10.1016/j.freeradbiomed.2010.11.029
GonzalezFlecha B, 1997, J BACTERIOL, V179, P6181
Han JM, 2012, CELL, V149, P410, DOI 10.1016/j.cell.2012.02.044
HARMAN D, 1956, J GERONTOL, V11, P298
Hillmann P, 2009, J MED CHEM, V52, P2762, DOI 10.1021/jm801442p
Hohmann-Marriott MF, 2011, ANNU REV PLANT BIOL, V62, P515, DOI 10.1146/annurev-arplant-042110-103811
Holland HD, 2006, PHILOS T R SOC B, V361, P903, DOI 10.1098/rstb.2006.1838
Howitz KT, 2008, CELL, V133, P387, DOI 10.1016/j.cell.2008.04.019
HWANG C, 1992, SCIENCE, V257, P1496, DOI 10.1126/science.1523409
IBSEN KH, 1961, CANCER RES, V21, P829
Jiang F, 2011, PHARMACOL REV, V63, P218, DOI 10.1124/pr.110.002980
Jones DP, 2010, J INTERN MED, V268, P432, DOI 10.1111/j.1365-2796.2010.02268.x
Karbowski M, 2010, ADV EXP MED BIOL, V687, P131
Klein EA, 2011, JAMA-J AM MED ASSOC, V306, P1549, DOI 10.1001/jama.2011.1437
Knoll AH, 2006, PHILOS T R SOC B, V361, P1023, DOI 10.1098/rstb.2006.1843
Laforgia J, 2006, J SPORT SCI, V24, P1247, DOI 10.1080/02640410600552064
Lin J, 2009, J NATL CANCER I, V101, P14, DOI 10.1093/jnci/djn438
Lippman SM, 2009, JAMA-J AM MED ASSOC, V301, P39, DOI 10.1001/jama.2008.864
Marques-da-Silva C, 2011, IMMUNOBIOLOGY, V216, P1, DOI 10.1016/j.imbio.2010.03.010
Muir John, 1911, MY 1 SUMMER SIERRA
Murakami A, 2012, FOOD FUNCT, V3, P462, DOI 10.1039/c2fo10274a
Navas P, 2010, J BIOENERG BIOMEMBR, V42, P181, DOI 10.1007/s10863-010-9272-0
Naviaux RK, 2008, CANCER BIOL THER, V7, P1191
Naviaux R K, 2000, Hum Reprod, V15 Suppl 2, P44
Niess AM, 2007, FRONT BIOSCI, V12, P4826, DOI 10.2741/2431
Pagliarini DJ, 2008, CELL, V134, P112, DOI 10.1016/j.cell.2008.06.016
Pittman RN, 2011, ACTA PHYSIOL, V202, P311, DOI 10.1111/j.1748-1716.2010.02232.x
Prigogine I, 1984, ORDER OUT CHAOS
Rasmussen B, 2008, NATURE, V455, P1101, DOI 10.1038/nature07381
Ristow M, 2011, FREE RADICAL BIO MED, V51, P327, DOI 10.1016/j.freeradbiomed.2011.05.010
Ristow M, 2009, P NATL ACAD SCI USA, V106, P8665, DOI 10.1073/pnas.0903485106
Rolfsson O, 2011, BMC SYST BIOL, V5, DOI 10.1186/1752-0509-5-155
Scandurra FM, 2010, ADV EXP MED BIOL, V662, P7, DOI 10.1007/978-1-4419-1241-1_2
Schellenberger J, 2010, BMC BIOINFORMATICS, V11, DOI 10.1186/1471-2105-11-213
Serezani CH, 2011, J CLIN INVEST, V121, P671, DOI 10.1172/JCI43302
SHEPHERD D, 1969, BIOCHEM J, V114, P597
Spath B, 2012, PLATELETS, V23, P60, DOI 10.3109/09537104.2011.590255
Speciale A, 2011, CURR MOL MED, V11, P770
Suksomboon N, 2011, J CLIN PHARM THER, V36, P53, DOI 10.1111/j.1365-2710.2009.01154.x
SUSSMAN I, 1980, BIOCHIM BIOPHYS ACTA, V591, P209, DOI 10.1016/0005-2728(80)90153-X
Tang KH, 2010, J BIOL CHEM, V285, P35848, DOI 10.1074/jbc.M110.157834
Tautenhahn R, 2011, ANAL CHEM, V83, P696, DOI 10.1021/ac102980g
Wamelink M, 2008, J INHERIT METAB DIS, V31, P703, DOI 10.1007/s10545-008-1015-6
Warburg O, 1928, BIOCHEM Z, V193, P339
West AP, 2011, NAT REV IMMUNOL, V11, P389, DOI 10.1038/nri2975
West JB, 2000, RESP PHYSL ESSENTIAL, V6th
Wichels A, 1998, APPL ENVIRON MICROB, V64, P4128
Winslow RM, 2007, RESP PHYSIOL NEUROBI, V158, P121, DOI 10.1016/j.resp.2007.03.011
Yanes O, 2011, ANAL CHEM, V83, P2152, DOI 10.1021/ac102981k
Yano T, 2010, MOL CELL BIOL, V30, P3758, DOI 10.1128/MCB.00121-10
Zhang Q, 2010, NATURE, V464, P104, DOI 10.1038/nature08780
NR 75
TC 32
Z9 34
PU AMER SOC PHARMACOLOGY EXPERIMENTAL THERAPEUTICS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3995 USA
SN 0022-3565
J9 J PHARMACOL EXP THER
JI J. Pharmacol. Exp. Ther.
PD SEP
PY 2012
VL 342
IS 3
BP 608
EP 618
DI 10.1124/jpet.112.192120
PG 11
WC Pharmacology & Pharmacy
SC Pharmacology & Pharmacy
GA 993SH
UT WOS:000307879400002
PM 22700427
ER
PT J
AU Yee, N
Schwarting, RKW
Fuchs, E
Wohr, M
AF Yee, Nicole
Schwarting, Rainer K. W.
Fuchs, Eberhard
Woehr, Markus
TI Increased affective ultrasonic communication during fear learning in
adult male rats exposed to maternal immune activation
SO JOURNAL OF PSYCHIATRIC RESEARCH
LA English
DT Article
DE 22-kHz; Ultrasonic vocalizations; Fear conditioning; Poly I:C; Anxiety;
Neurodevelopmental disorder
ID SOUND CHARACTERISTICS; PRENATAL INFECTION; SPEAKING BEHAVIOR;
BRAIN-DEVELOPMENT; SCHIZOPHRENIA; VOCALIZATIONS; CALLS; MICE; SIGNALS;
PLAYBACK
AB Maternal exposure to infection during pregnancy greatly increases the risk of psychopathology in the offspring. In support of clinical findings, rodent models of maternal immune activation (MIA) show that prenatal exposure to pathogens can induce phenotypic changes in the offspring associated with schizophrenia, autism, depression and anxiety. In the current study, we investigated the effects of MIA via polyinosinic:polycytidylic acid (poly I:C) on emotional behavior and communication in rats. Pregnant rats were administered poly I:C or saline on gestation day 15 and male offspring were tested in an auditory fear conditioning paradigm in early adulthood. We found that prenatal poly I:C exposure significantly altered affective signaling, namely, the production of aversive 22-kHz ultrasonic vocalizations (USVs), in terms of call number, structure and temporal patterning. MIA led to an increase in aversive 22-kHz USVs to 300% of saline controls. Offspring exposed to MIA not only emitted more 22-kHz USVs, but also emitted calls that were shorter in duration and occurred in bouts containing more calls. The production of appetitive 50-kHz USVs and audible calls was not affected. Intriguingly, alterations in aversive 22-kHz USV emission were observed despite no obvious changes in overt defensive behavior, which highlights the importance of assessing USVs as an additional measure of fear. Aversive 22-kHz USVs are a prominent part of the rat's defensive behavioral repertoire and serve important communicative functions, most notably as alarm calls. The observed changes in aversive 22-kHz USVs show that MIA has long-term effects on emotional behavior and communication in exposed rat offspring. (C) 2012 Elsevier Ltd. All rights reserved.
C1 [Yee, Nicole; Fuchs, Eberhard] German Primate Ctr, Leibniz Inst Primate Res, Clin Neurobiol Lab, D-37077 Gottingen, Germany.
[Schwarting, Rainer K. W.; Woehr, Markus] Univ Marburg, D-35032 Marburg, Germany.
[Fuchs, Eberhard] Univ Gottingen, Dept Neurol, Sch Med, D-3400 Gottingen, Germany.
RP Yee, N (reprint author), German Primate Ctr, Leibniz Inst Primate Res, Clin Neurobiol Lab, Kellnerweg 4, D-37077 Gottingen, Germany.
EM nyee@cnl-dpz.de
FU Kurt Lange Stiftung
FX The authors wish to thank Cornelia Heckmann, Christina Coenen de Roo and
Dennis Bogaert for technical assistance with experiments. Nicole Yee is
financially supported by the Kurt Lange Stiftung.
CR Abazyan B, 2010, BIOL PSYCHIAT, V68, P1172, DOI 10.1016/j.biopsych.2010.09.022
American Psychiatric Association, 2000, DIAGN STAT MAN MENT
Baharnoori M, 2012, SCHIZOPHRENIA BULL, V38, P444, DOI 10.1093/schbul/sbq098
Bitanihirwe BKY, 2010, NEUROPSYCHOPHARMACOL, V35, P2462, DOI 10.1038/npp.2010.129
BLANCHAR.RJ, 1969, J COMP PHYSIOL PSYCH, V67, P370, DOI 10.1037/h0026779
BLANCHARD RJ, 1991, PHYSIOL BEHAV, V50, P967, DOI 10.1016/0031-9384(91)90423-L
Boksa P, 2010, BRAIN BEHAV IMMUN, V24, P881, DOI 10.1016/j.bbi.2010.03.005
Borta A, 2006, BEHAV BRAIN RES, V166, P271, DOI 10.1016/j.bbr.2005.08.009
Brown AS, 2010, AM J PSYCHIAT, V167, P261, DOI 10.1176/appi.ajp.2009.09030361
D'Amato FR, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0018637
Dauger S, 1998, RESP PHYSIOL, V112, P215, DOI 10.1016/S0034-5687(98)00027-9
DeLisi LE, 2001, SCHIZOPHRENIA BULL, V27, P481
Ehninger D, 2012, MOL PSYCHIATR, V17, P62, DOI 10.1038/mp.2010.115
EHRET G, 1987, NATURE, V325, P249, DOI 10.1038/325249a0
Endres T, 2007, BEHAV BRAIN RES, V185, P69, DOI 10.1016/j.bbr.2007.07.012
Fendt M, 1999, NEUROSCI BIOBEHAV R, V23, P743, DOI 10.1016/S0149-7634(99)00016-0
FRITH U, 1994, PHILOS T ROY SOC B, V346, P97, DOI 10.1098/rstb.1994.0133
Genest SE, 2007, J APPL PHYSIOL, V102, P1416, DOI 10.1152/japplphysiol.00454.2006
Golan HM, 2005, NEUROPHARMACOLOGY, V48, P903, DOI 10.1016/j.neuropharm.2004.12.023
Hammerschmidt K, 2009, BIOL LETTERS, V5, P589, DOI 10.1098/rsbl.2009.0317
Hegoburu C, 2011, FRONT BEHAV NEUROSCI, V5, DOI 10.3389/fnbeh.2011.00025
Homma I, 2008, EXP PHYSIOL, V93, P1011, DOI 10.1113/expphysiol.2008.042424
Knutson B, 2002, PSYCHOL BULL, V128, P961, DOI 10.1037//0033-2909.128.6.961
Knutson B, 1999, PHYSIOL BEHAV, V66, P639, DOI 10.1016/S0031-9384(98)00337-0
Knutson B, 1998, J COMP PSYCHOL, V112, P65, DOI 10.1037/0735-7036.112.1.65
Malkova NV, 2012, BRAIN BEHAV IMMUN, V26, P607, DOI 10.1016/j.bbi.2012.01.011
Meyer U, 2012, NEUROPHARMACOLOGY, V62, P1308, DOI 10.1016/j.neuropharm.2011.01.009
Parsana AJ, 2012, BEHAV BRAIN RES, V226, P77, DOI 10.1016/j.bbr.2011.08.040
Patterson PH, 2011, TRENDS MOL MED, V17, P389, DOI 10.1016/j.molmed.2011.03.001
POMERANTZ SM, 1983, PHYSIOL BEHAV, V31, P91, DOI 10.1016/0031-9384(83)90101-4
Puschel J, 1998, J PSYCHIAT RES, V32, P89, DOI 10.1016/S0022-3956(98)00046-6
Sadananda M, 2008, NEUROSCI LETT, V435, P17, DOI 10.1016/j.neulet.2008.02.002
SEWELL GD, 1970, NATURE, V227, P410, DOI 10.1038/227410a0
Smith SEP, 2007, J NEUROSCI, V27, P10695, DOI 10.1523/JNEUROSCI.2178-07.2007
STASSEN HH, 1995, J PSYCHIAT RES, V29, P277, DOI 10.1016/0022-3956(95)00004-O
VANDERPOEL AM, 1989, PSYCHOPHARMACOLOGY, V97, P147
VANDERPOEL AM, 1991, BEHAVIOUR, V119, P127, DOI 10.1163/156853991X00409
Wohr M, 2005, NEUROBIOL LEARN MEM, V84, P228, DOI 10.1016/j.nlm.2005.07.004
Wohr M, 2007, PLOS ONE, V2, DOI 10.1371/journal.pone.0001365
Wohr M, 2010, HBK BEHAV NEUROSCI, V19, P113, DOI 10.1016/B978-0-12-374593-4.00012-7
Wolff AR, 2011, BEHAV BRAIN RES, V225, P382, DOI 10.1016/j.bbr.2011.07.033
Wolff AR, 2008, BEHAV BRAIN RES, V190, P156, DOI 10.1016/j.bbr.2008.02.021
Yee N, 2011, BEHAV BRAIN RES, V224, P180, DOI 10.1016/j.bbr.2011.05.040
Yee N, 2012, STRESS, V15, P533, DOI 10.3109/10253890.2011.646348
Zuberbuhler K, 2009, ADV STUD BEHAV, V40, P277, DOI 10.1016/S0065-3454(09)40008-1
Zuckerman L, 2005, J PSYCHIAT RES, V39, P311, DOI 10.1016/j.jpsychires.2004.08.008
NR 46
TC 10
Z9 10
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0022-3956
J9 J PSYCHIATR RES
JI J. Psychiatr. Res.
PD SEP
PY 2012
VL 46
IS 9
BP 1199
EP 1205
DI 10.1016/j.jpsychires.2012.05.010
PG 7
WC Psychiatry
SC Psychiatry
GA 993MN
UT WOS:000307863900013
PM 22687817
ER
PT J
AU Bhattacharya, A
Klann, E
AF Bhattacharya, Aditi
Klann, Eric
TI The molecular basis of cognitive deficits in pervasive developmental
disorders
SO LEARNING & MEMORY
LA English
DT Review
ID RUBINSTEIN-TAYBI-SYNDROME; LONG-TERM POTENTIATION; FRAGILE-X-SYNDROME;
AUTISM SPECTRUM DISORDERS; KNOCK-OUT MICE; TUBEROUS SCLEROSIS COMPLEX;
WORKING-MEMORY PERFORMANCE; MENTAL-RETARDATION PROTEIN; CELL-ADHESION
MOLECULE; LEMLI-OPITZ-SYNDROME
AB Persons with pervasive developmental disorders (PDD) exhibit a range of cognitive deficits that hamper their quality of life, including difficulties involving communication, sociability, and perspective-taking. In recent years, a variety of studies in mice that model genetic syndromes with a high risk of PDD have provided insights into the underlying molecular mechanisms associated with these disorders. What is less appreciated is how the molecular anomalies affect neuronal and circuit function to give rise to the cognitive deficits associated with PDD. In this review, we describe genetic mutations that cause PDD and discuss how they alter fundamental social and cognitive processes. We then describe efforts to correct cognitive impairments associated with these disorders and identify areas of further inquiry in the search for molecular targets for therapeutics for PDD.
C1 [Bhattacharya, Aditi; Klann, Eric] NYU, Ctr Neural Sci, New York, NY 10003 USA.
RP Klann, E (reprint author), NYU, Ctr Neural Sci, New York, NY 10003 USA.
EM eklann@cns.nyu.edu
FU National Institute of Health [NS034007, NS047384]; FRAXA Research
Foundation
FX This work was supported by National Institute of Health grants NS034007
and NS047384 (E.K.) and the FRAXA Research Foundation (A.B.). We
apologize to our fellow scientists whose work could not be cited due to
space limitations.
CR Adachi M, 2009, J NEUROSCI, V29, P4218, DOI 10.1523/JNEUROSCI.4225-08.2009
Adamczyk A, 2012, BEHAV BRAIN RES, V229, P265, DOI 10.1016/j.bbr.2012.01.007
Alarcon JM, 2004, NEURON, V42, P947, DOI 10.1016/j.neuron.2004.05.021
Alberini CM, 2012, TRENDS NEUROSCI, V35, P274, DOI 10.1016/j.tins.2011.12.007
Allensworth M, 2011, BMC GENET, V12, DOI 10.1186/1471-2156-12-7
American Psychiatric Association, 2000, DIAGN STAT MAN MENT
Bader PL, 2011, P NATL ACAD SCI USA, V108, P15432, DOI 10.1073/pnas.1112667108
Bangash MA, 2011, CELL, V145, P758, DOI 10.1016/j.cell.2011.03.052
Baron-Cohen S, 2004, J NEUROL NEUROSUR PS, V75, P945, DOI 10.1136/jnnp.2003.018713
Baron-Cohen S, 2010, PROG BRAIN RES, V186, P167, DOI 10.1016/B978-0-444-53630-3.00011-7
Bartal IBA, 2011, SCIENCE, V334, P1427, DOI 10.1126/science.1210789
Bertelli M, 2009, J CLIN NEUROSCI, V16, P1061, DOI 10.1016/j.jocn.2008.12.011
Betancur C, 2011, BRAIN RES, V1380, P42, DOI 10.1016/j.brainres.2010.11.078
Bingol B, 2011, NEURON, V69, P22, DOI 10.1016/j.neuron.2010.11.006
Bishop SL, 2011, AUTISM RES, V4, P317, DOI 10.1002/aur.216
Blundell J, 2009, GENES BRAIN BEHAV, V8, P114, DOI 10.1111/j.1601-183X.2008.00455.x
Bourtchouladze R, 2003, P NATL ACAD SCI USA, V100, P10518, DOI 10.1073/pnas.1834280100
Bozdagi O, 2010, J NEUROSCI, V30, P2115
Calfa G, 2011, EXP BIOL MED, V236, P3, DOI 10.1258/ebm.2010.010261
Ceballos-Picot I, 2009, HUM MOL GENET, V18, P2317, DOI 10.1093/hmg/ddp164
Chao HT, 2010, NATURE, V468, P263, DOI 10.1038/nature09582
Chauhan A, 2011, J NEUROCHEM, V117, P209, DOI 10.1111/j.1471-4159.2011.07189.x
Chen PC, 2010, J CLIN INVEST, V120, P4353, DOI 10.1172/JCI43910
Chen RZ, 2001, NAT GENET, V27, P327, DOI 10.1038/85906
Cheng EP, 2011, CIRC RES, V109, P255, DOI 10.1161/CIRCRESAHA.111.248252
Chevere-Torres I, 2012, NEUROBIOL DIS, V45, P1101, DOI 10.1016/j.nbd.2011.12.028
Collins AL, 2004, HUM MOL GENET, V13, P2679, DOI 10.1093/hmg/ddh282
Cox MM, 2009, GENES BRAIN BEHAV, V8, P390, DOI 10.1111/j.1601-183X.2009.00477.x
Crawley JN, 2007, WHATS WRONG MY MOUSE
Dahlhaus R, 2010, BEHAV BRAIN RES, V208, P96, DOI 10.1016/j.bbr.2009.11.019
Dahlhaus R, 2010, HIPPOCAMPUS, V20, P305, DOI 10.1002/hipo.20630
De Felice C, 2012, GENES NUTR, V7, P447, DOI 10.1007/s12263-012-0285-7
Dhillon S, 2011, CURR GENOMICS, V12, P322, DOI 10.2174/138920211796429745
Di Nardo A, 2009, J NEUROSCI, V29, P5926, DOI 10.1523/JNEUROSCI.0778-09.2009
Ehninger D, 2012, MOL PSYCHIATR, V17, P62, DOI 10.1038/mp.2010.115
Ehninger D, 2008, NAT MED, V14, P843, DOI 10.1038/nm1788
Etherton MR, 2009, P NATL ACAD SCI USA, V106, P17998, DOI 10.1073/pnas.0910297106
Fischer J, 2011, GENES BRAIN BEHAV, V10, P17, DOI 10.1111/j.1601-183X.2010.00610.x
Frustaci A, 2012, FREE RADICAL BIO MED, V52, P2128, DOI 10.1016/j.freeradbiomed.2012.03.011
Fujita E, 2010, CELL DEATH DIS, V1, DOI 10.1038/cddis.2010.23
Gemelli T, 2006, BIOL PSYCHIAT, V59, P468, DOI 10.1016/j.biopsych.2005.07.025
Gitiaux C, 2009, EUR J HUM GENET, V17, P133, DOI 10.1038/ejhg.2008.174
Goebel-Goody SM, 2012, GENES BRAIN BEHAV, DOI [10.1111/j.1601-183X2012.00781, DOI 10.1111/J.1601-183X2012.00781]
Grant SGN, 2012, CURR OPIN NEUROBIOL, V22, P522, DOI 10.1016/j.conb.2012.02.002
Gross C, 2012, NEUROPSYCHOPHARMACOL, V37, P178, DOI 10.1038/npp.2011.137
Gu YH, 2002, J NEUROSCI, V22, P2753
Guo XC, 2009, NEUROPSYCHOPHARMACOL, V34, P1659, DOI 10.1038/npp.2008.223
Guy J, 2001, NAT GENET, V27, P322, DOI 10.1038/85899
Guy J, 2007, SCIENCE, V315, P1143, DOI 10.1126/science.1138389
Hebert DN, 2007, PHYSIOL REV, V87, P1377, DOI 10.1152/physrev.00050.2006
Hines RM, 2008, J NEUROSCI, V28, P6055, DOI 10.1523/JNEUROSCI.0032-08.2008
Hoeffer CA, 2010, TRENDS NEUROSCI, V33, P67, DOI 10.1016/j.tins.2009.11.003
Hu DY, 2007, NEUROBIOL LEARN MEM, V87, P372, DOI 10.1016/j.nlm.2006.10.003
Hutchinson AN, 2012, NEUROPSYCHOPHARMACOL, V37, P321, DOI 10.1038/npp.2011.190
Jamain S, 2008, P NATL ACAD SCI USA, V105, P1710, DOI 10.1073/pnas.0711555105
Jiang YH, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0012278
Jiang YH, 1998, NEURON, V21, P799, DOI 10.1016/S0896-6273(00)80596-6
Jin P, 2004, NAT NEUROSCI, V7, P113, DOI 10.1038/nn1174
Josselyn SA, 2005, LEARN MEMORY, V12, P80, DOI 10.1101/lm.93505
Kamat PK, 2011, PHARMACOL BIOCHEM BE, V100, P311, DOI 10.1016/j.pbb.2011.08.019
Kao DI, 2010, P NATL ACAD SCI USA, V107, P15601, DOI 10.1073/pnas.1010564107
Kaphzan H, 2012, BIOL PSYCHIAT, V72, P182, DOI 10.1016/j.biopsych.2012.01.021
Karlsgodt KH, 2011, BIOL PSYCHIAT, V69, P28, DOI 10.1016/j.biopsych.2010.09.012
Kelleher RJ, 2008, CELL, V135, P401, DOI 10.1016/j.cell.2008.10.017
Kent L, 2008, AM J MED GENET B, V147B, P1295, DOI 10.1002/ajmg.b.30729
Khelfaoui M, 2007, J NEUROSCI, V27, P9439, DOI 10.1523/JNEUROSCI.2029-07.2007
Klejbor I, 2009, SCHIZOPHR RES, V113, P308, DOI 10.1016/j.schres.2009.06.006
Korade Z, 2008, NEUROPHARMACOLOGY, V55, P1265, DOI 10.1016/j.neuropharm.2008.02.019
Kumar RA, 2010, CLIN GENET, V78, P519, DOI 10.1111/j.1399-0004.2010.01530_2.x
Kwon CH, 2006, NEURON, V50, P377, DOI 10.1016/j.neuron.2006.03.023
Laarakker MC, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0031503
Lalande M, 2007, CELL MOL LIFE SCI, V64, P947, DOI 10.1007/s00018-007-6460-0
LAUREYS G, 1988, GENOMICS, V3, P224, DOI 10.1016/0888-7543(88)90083-3
Lee SH, 2008, SCIENCE, V319, P1253, DOI 10.1126/science.1150541
Leoncini S, 2011, REDOX REP, V16, P145, DOI 10.1179/1351000211Y.0000000004
Li Y, 2012, J NEUROSCI, V32, P3529, DOI 10.1523/JNEUROSCI.3469-11.2012
Liu-Yesucevitz L, 2011, J NEUROSCI, V31, P16086, DOI 10.1523/JNEUROSCI.4105-11.2011
Lodish H.F., 2008, MOL CELL BIOL
Lopez-Salon M, 2001, EUR J NEUROSCI, V14, P1820, DOI 10.1046/j.0953-816x.2001.01806.x
Manzi B, 2008, J CHILD NEUROL, V23, P307, DOI 10.1177/0883073807308698
Marley A, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009325
Massaad CA, 2011, ANTIOXID REDOX SIGN, V14, P2013, DOI 10.1089/ars.2010.3208
Maul B, 2008, J MOL MED, V86, P563, DOI 10.1007/s00109-008-0316-4
McPartland JC, 2011, CURR OPIN PEDIATR, V23, P628, DOI 10.1097/MOP.0b013e32834cb9c9
Mejias R, 2011, P NATL ACAD SCI USA, V108, P4920, DOI 10.1073/pnas.1102233108
Melko M, 2010, BIOCHIMIE, V92, P919, DOI 10.1016/j.biochi.2010.05.018
Mines MA, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009706
Miura K, 2002, NEUROBIOL DIS, V9, P149, DOI 10.1006/nbdi.2001.0463
Morabito MV, 2010, NEUROBIOL DIS, V39, P169, DOI 10.1016/j.nbd.2010.04.004
Moretti P, 2006, J NEUROSCI, V26, P319, DOI 10.1523/JNEUROSCI.2623-05.2006
Muhia M, 2009, BEHAV NEUROSCI, V123, P1114, DOI 10.1037/a0017118
Muhia M, 2010, EUR J NEUROSCI, V31, P529, DOI 10.1111/j.1460-9568.2010.07079.x
Na ES, 2012, NAT GEN, V8, P206
Nava C, 2007, J MED GENET, V44, P763, DOI 10.1136/jmg.2007.050450
Neves-Pereira M, 2009, J MED GENET, V46, P759, DOI 10.1136/jmg.2009.066852
Nyhan WL, 2000, GENEREVIEW
O'Brien WT, 2002, BEHAV BRAIN RES, V129, P141, DOI 10.1016/S0166-4328(01)00342-4
Ogiwara I, 2007, J NEUROSCI, V27, P5903, DOI 10.1523/JNEUROSCI.5270-06.2007
Otte DM, 2011, NEUROPSYCHOPHARMACOL, V36, P2233, DOI 10.1038/npp.2011.109
Palmieri L, 2010, MOL PSYCHIATR, V15, P38, DOI 10.1038/mp.2008.63
Panksepp JB, 2011, NEUROSCI BIOBEHAV R, V35, P1864, DOI 10.1016/j.neubiorev.2011.05.013
Park Soornin, 2008, V427, P3, DOI 10.1007/978-1-59745-273-1_1
Pelc Karine, 2008, Neuropsychiatr Dis Treat, V4, P577
Penagarikano O, 2011, CELL, V147, P235, DOI 10.1016/j.cell.2011.08.040
Pindolia K, 2011, MOL GENET METAB, V102, P161, DOI 10.1016/j.ymgme.2010.10.005
Qualmann B, 2011, EMBO J, V30, P3501, DOI 10.1038/emboj.2011.266
Radyushkin K, 2009, GENES BRAIN BEHAV, V8, P416, DOI 10.1111/j.1601-183X.2009.00487.x
Ramakers GJA, 2012, HUM MOL GENET, V21, P268, DOI 10.1093/hmg/ddr457
Rammal H, 2010, EUR J PHARMACOL, V627, P173, DOI 10.1016/j.ejphar.2009.11.001
Ropers HH, 2010, ANNU REV GENOM HUM G, V11, P161, DOI 10.1146/annurev-genom-082509-141640
Rossignol DA, 2012, MOL PSYCHIATR, V17, P290, DOI 10.1038/mp.2010.136
Ross-Inta C, 2010, BIOCHEM J, V429, P545, DOI 10.1042/BJ20091960
Rotschafer SE, 2012, BRAIN RES, V1439, P7, DOI 10.1016/j.brainres.2011.12.041
Roubertoux PL, 2003, NAT GENET, V35, P65, DOI 10.1038/ng1230
Rubenstein JLR, 2011, J CHILD PSYCHOL PSYC, V52, P339, DOI 10.1111/j.1469-7610.2010.02307.x
Rudenko O, 2010, NEUROSCI RES, V68, P35, DOI 10.1016/j.neures.2010.05.002
RUTTER M, 1970, SEMIN PSYCHIAT, V2, P435
RUTTER M, 1973, J CHILD PSYCHOL PSYC, V14, P241
Sadakata T, 2007, J CLIN INVEST, V117, P931, DOI 10.1172/JCI29031
Sadakata T, 2012, FEBS J, V279, P384, DOI 10.1111/j.1742-4658.2011.08431.x
Sajdel-Sulkowska EM, 2011, CEREBELLUM, V10, P43, DOI 10.1007/s12311-010-0223-4
Sakurai M, 2008, EUR J NEUROSCI, V27, P691, DOI 10.1111/j.1460-9568.2008.06047.x
Samaco RC, 2009, P NATL ACAD SCI USA, V106, P21966, DOI 10.1073/pnas.0912257106
Samaco RC, 2012, NAT GENET, V44, P206, DOI 10.1038/ng.1066
Sartori S, 2008, J CHILD NEUROL, V23, P912, DOI 10.1177/0883073808316367
Shahbazian MD, 2002, NEURON, V35, P243, DOI 10.1016/S0896-6273(02)00768-7
Shi JH, 2008, J BIOL CHEM, V283, P28660, DOI 10.1074/jbc.M802645200
Shilyansky C, 2010, P NATL ACAD SCI USA, V107, P13141, DOI 10.1073/pnas.1004829107
Sikora DM, 2006, AM J MED GENET A, V140A, P1511, DOI 10.1002/ajmg.a.31294
Silverman J. L., 2010, BRAIN RES, V1380, P120, DOI [10.1016/j.brainres.2010.09.026, DOI 10.1016/J.BRAINRES.2010.09.026]
Silverman JL, 2010, NAT REV NEUROSCI, V11, P490, DOI 10.1038/nrn2851
Smith SEP, 2011, SCI TRANSL MED, V3, DOI 10.1126/scitranslmed.3002627
Splawski I, 2004, CELL, V119, P19, DOI 10.1016/j.cell.2004.09.011
Stettner GM, 2011, AM J MED GENET A, V155A, P2003, DOI 10.1002/ajmg.a.34122
Stromme P, 2011, BRAIN, V134, P3369, DOI 10.1093/brain/awr250
Tabuchi K, 2007, SCIENCE, V318, P71, DOI 10.1126/science.1146221
Tai HC, 2008, NAT REV NEUROSCI, V9, P826, DOI 10.1038/nrn2499
Vaillend C, 2004, NEUROBIOL DIS, V17, P10, DOI 10.1016/j.nbd.2004.05.004
Vaillend C, 1999, NEUROMUSCULAR DISORD, V9, P296, DOI 10.1016/S0960-8966(99)00029-2
van Bokhoven H, 2011, ANNU REV GENET, V45, P81, DOI 10.1146/annurev-genet-110410-132512
van Woerden GM, 2007, NAT NEUROSCI, V10, P280, DOI 10.1038/nn1845
Wang J, 2010, DEV CELL, V18, P114, DOI 10.1016/j.devcel.2009.10.023
Wang X, 2010, HUM MOL GENET, V20, P3093
Weaving LS, 2004, AM J HUM GENET, V75, P1079, DOI 10.1086/426462
WHO, 2004, INT STAT CLASS DIS H
WING L, 1981, PSYCHOL MED, V11, P115
Wohr M, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0020631
Wood MA, 2005, LEARN MEMORY, V12, P111, DOI 10.1101/lm.86605
Wood MA, 2005, HIPPOCAMPUS, V15, P610, DOI 10.1002/hipo.20082
Wu X, 2011, J CLIN INVEST, V121, P1009, DOI 10.1172/JCI44929
Xu GR, 1998, METABOLISM, V47, P878, DOI 10.1016/S0026-0495(98)90130-5
Xu LB, 2011, J LIPID RES, V52, P1222, DOI 10.1194/jlr.M014498
Yang M, 2012, J NEUROSCI, V32, P6525, DOI 10.1523/JNEUROSCI.6107-11.2012
Young DM, 2010, P NATL ACAD SCI USA, V107, P11074, DOI 10.1073/pnas.1005620107
Zhang C, 2009, J NEUROSCI, V29, P10843, DOI 10.1523/JNEUROSCI.1248-09.2009
Zhao MR, 2007, BIOL PSYCHIAT, V62, P381, DOI 10.1016/j.biopsych.2006.10.019
Zhou J, 2009, J NEUROSCI, V29, P1773, DOI 10.1523/JNEUROSCI.5685-08.2009
Zhuravliova E, 2009, BEHAV BRAIN RES, V205, P377, DOI 10.1016/j.bbr.2009.07.009
NR 158
TC 2
Z9 2
PU COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
PI COLD SPRING HARBOR
PA 1 BUNGTOWN RD, COLD SPRING HARBOR, NY 11724 USA
SN 1072-0502
J9 LEARN MEMORY
JI Learn. Mem.
PD SEP
PY 2012
VL 19
IS 9
BP 434
EP 443
DI 10.1101/lm.025007.111
PG 10
WC Neurosciences; Psychology, Experimental
SC Neurosciences & Neurology; Psychology
GA 011MX
UT WOS:000309170200010
PM 22904374
ER
PT J
AU Oro, AB
Briseno, JV
Garcia, CAC
Sepulveda, RFC
Villalobos, AMH
Sanchez, CE
AF Bravo Oro, A.
Vazquez Briseno, J.
Cuello Garcia, C. A.
Calderon Sepulveda, R. F.
Hernandez Villalobos, A. M.
Esmer Sanchez, C.
TI Early manifestations of autism spectrum disorders. Experience of 393
cases in a paediatric neurology
SO NEUROLOGIA
LA Spanish
DT Article
DE Autism spectrum disorders; Language disorders; Autism;
Neurodevelopmental delay; Early detection; Epidemiological data
ID PERVASIVE DEVELOPMENTAL DISORDERS; SPECIAL NEEDS; PROJECT SNAP;
CHILDREN; PREVALENCE; CHILDHOOD; DIAGNOSIS; EPILEPSY
AB Introduction: Autism spectrum disorders are group of conditions characterised by qualitative impairments in social communication, interaction, and imagination, and by a restricted range of interests and typical repetitive behaviours. Frequently, there is a delay in the age of detection, and therefore in starting multidisciplinary evaluations and interventions, which may result in a poorer prognosis and reduced quality of life for both children and parents. The aim of our study was to describe clinical and epidemiological data including the age of detection and main initial complaints present in children with autism disorders referred to a paediatric neurology centre.
Patients and methods: A total of 393 medical records of consecutive cases diagnosed with an autism spectrum disorder were reviewed.
Results: Autism was diagnosed in 82.1% of the cases, unspecified pervasive disorder in 9.9%, Asperger syndrome in 4.8%, and Rett syndrome in 3%. Sixty percent of autistic children presented with a language disorder as their main complaint. The average age of detection was 4 years.
Conclusions: Compared with other countries, age of detection is delayed. Primary care-based screening and surveillance are required in order to improve prognosis and quality of life of children with an autism spectrum disorder. (C) 2011 Sociedad Espanola de Neurologia. Published by Elsevier Espana, S.L. All rights reserved.
C1 [Bravo Oro, A.] Hosp Cent Dr Ignacio Morones Prieto, Dept Neuropediat, San Luis Potosi, Slp, Mexico.
[Vazquez Briseno, J.] Hosp Reg Alta Especialidad Bajio, Dept Neuropediat, Leon, Gto, Mexico.
[Cuello Garcia, C. A.] ITESM, Escuela Med, Dept Pediat & Invest Clin, Monterrey, NL, Mexico.
[Calderon Sepulveda, R. F.] Ctr Neurol Ninos & Adolescentes CENNA, Dept Neuropediat & Neuropsicol, Monterrey, NL, Mexico.
[Hernandez Villalobos, A. M.] Ctr Neurol Ninos & Adolescentes CENNA, Dept Neuropsicol, Monterrey, NL, Mexico.
[Esmer Sanchez, C.] Hosp Cent Dr Ignacio Morones Prieto, Dept Genet, San Luis Potosi, Slp, Mexico.
RP Oro, AB (reprint author), Hosp Cent Dr Ignacio Morones Prieto, Dept Neuropediat, San Luis Potosi, Slp, Mexico.
EM antoniobravooro@hotmail.com
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
American Psychiatric Association, 1980, DIAGN STAT MAN MENT
[Anonymous], NOM031SSA21999
Asperger H, 1944, ARCH PSYCHIAT NERVEN, V117, P76, DOI 10.1007/BF01837709
Baird G, 2006, LANCET, V368, P210, DOI 10.1016/S0140-6736(06)69041-7
Bauman ML, 2010, NEUROTHERAPEUTICS, V7, P320, DOI 10.1016/j.nurt.2010.06.001
Caglayan AO, 2010, DEV MED CHILD NEUROL, V52, P130, DOI 10.1111/j.1469-8749.2009.03523.x
CDC, 2009, MMWR SURVEILL SUMM, V58, P1
Chakrabarti S, 2005, AM J PSYCHIAT, V162, P1133, DOI 10.1176/appi.ajp.162.6.1133
Charman T, 2011, BRAIN RES, V1380, P10, DOI 10.1016/j.brainres.2010.10.075
Charman T, 2011, PSYCHOL MED, V41, P619, DOI 10.1017/S0033291710000991
Danielsson S, 2005, EPILEPSIA, V46, P918, DOI 10.1111/j.1528-1167.2005.57504.x
Dawson G, 2010, PEDIATRICS, V125, pE17, DOI 10.1542/peds.2009-0958
Fombonne E, 2009, PEDIATR RES, V65, P591, DOI 10.1203/PDR.0b013e31819e7203
Fusar-Poli P, 2008, AM J PSYCHIAT, V165, P1407, DOI 10.1176/appi.ajp.2008.08050714
Geschwind DH, 2007, CURR OPIN NEUROBIOL, V17, P103, DOI 10.1016/j.conb.2007.01.009
Howlin P, 2009, AJIDD-AM J INTELLECT, V114, P23, DOI 10.1352/2009.114:23;nd41
Jeste SS, 2011, CURR OPIN NEUROL, V24, P132, DOI 10.1097/WCO.0b013e3283446450
Kanner L, 1943, NERV CHILD, V2, P217
Levy SE, 2009, LANCET, V374, P1627, DOI 10.1016/S0140-6736(09)61376-3
Miles JH, 2011, GENET MED, V13, P278, DOI 10.1097/GIM.0b013e3181ff67ba
Milne E, 2011, FRONT PSYCHOL, V2, DOI 10.3389/fpsyg.2011.00051
Newschaffer C., 2005, PEDIATRICS, V115, P277
Nicholas JS, 2008, ANN EPIDEMIOL, V18, P130, DOI 10.1016/i.annepidem.2007.10.013
Ozonoff S, 2010, J AM ACAD CHILD PSY, V49, P256, DOI 10.1016/j.jaac.2009.11.009
Parmeggiani A, 2010, BRAIN DEV-JPN, V32, P783, DOI 10.1016/j.braindev.2010.07.003
Persico AM, 2006, TRENDS NEUROSCI, V29, P349, DOI 10.1016/j.tins.2006.05.010
Rapin I, 1997, NEW ENGL J MED, V337, P97, DOI 10.1056/NEJM199707103370206
ROGERS SJ, 1990, J AM ACAD CHILD PSY, V29, P863, DOI 10.1097/00004583-199011000-00004
Schaefer GB, 2008, GENET MED, V10, P4, DOI 10.1097/GIM.0b013e31815efdd7
Shen Y, 2010, PEDIATRICS, V125, P727
TUCHMAN RF, 1991, PEDIATRICS, V88, P1211
Tuchman RF, 1997, PEDIATRICS, V99, P560, DOI 10.1542/peds.99.4.560
Veness C, 2011, AUTISM, P6
Wetherby AM, 2007, J AUTISM DEV DISORD, V37, P960, DOI 10.1007/s10803-006-0237-4
Wing L, 1997, LANCET, V350, P1761, DOI 10.1016/S0140-6736(97)09218-0
Wing L, 1993, Eur Child Adolesc Psychiatry, V2, P61, DOI 10.1007/BF02098832
World Health Organization, 1993, MENT DIS GLOSS GUID
Zwaigenbaum L, 2009, PEDIATRICS, V123, P1383, DOI 10.1542/peds.2008-1606
NR 39
TC 1
Z9 1
PU ELSEVIER DOYMA SL
PI BARCELONA
PA TRAVESERA DE GARCIA, 17-21, BARCELONA, 08021, SPAIN
SN 0213-4853
J9 NEUROLOGIA
JI Neurologia
PD SEP
PY 2012
VL 27
IS 7
BP 414
EP 420
DI 10.1016/j.nrl.2011.09.011
PG 7
WC Clinical Neurology
SC Neurosciences & Neurology
GA 013PZ
UT WOS:000309318600005
ER
PT J
AU Pisano, T
Barkovich, AJ
Leventer, RJ
Squier, W
Scheffer, IE
Parrini, E
Blaser, S
Marini, C
Robertson, S
Tortorella, G
Rosenow, F
Thomas, P
McGillivray, G
Andermann, E
Andermann, F
Berkovic, SF
Dobyns, WB
Guerrini, R
AF Pisano, Tiziana
Barkovich, A. James
Leventer, Richard J.
Squier, Waney
Scheffer, Ingrid E.
Parrini, Elena
Blaser, Susan
Marini, Carla
Robertson, Stephen
Tortorella, Gaetano
Rosenow, Felix
Thomas, Pierre
McGillivray, George
Andermann, Eva
Andermann, Frederick
Berkovic, Samuel F.
Dobyns, William B.
Guerrini, Renzo
TI Peritrigonal and temporo-occipital heterotopia with corpus callosum and
cerebellar dysgenesis
SO NEUROLOGY
LA English
DT Article
ID PERIVENTRICULAR NODULAR HETEROTOPIA; CORTICAL DEVELOPMENT;
CEREBRAL-CORTEX; MUTATIONS; BRAIN; POLYMICROGYRIA; MALFORMATIONS;
MIGRATION; EPILEPSY; GENES
AB Objective: To describe a homogeneous subtype of periventricular nodular heterotopia (PNH) as part of a newly defined malformation complex.
Methods: Observational study including review of brain MRI and clinical findings of a cohort of 50 patients with PNH in the temporo-occipital horns and trigones, mutation analysis of the FLNA gene, and anatomopathologic study of a fetal brain.
Results: There were 28 females and 22 males. All were sporadic with the exception of an affected mother and son. Epilepsy occurred in 62%, cerebellar signs in 56%, cognitive impairment in 56%, and autism in 12%. Seventy percent were referred within the 3rd year of life. Imaging revealed a normal cerebral cortex in 76% and abnormal cortical folding in 24%. In all patients the hippocampi were under-rotated and in 10% they merged with the heterotopia. Cerebellar dysgenesis was observed in 84% and a hypoplastic corpus callosum in 60%. There was no gender bias or uneven gender distribution of clinical and anatomic severity. No mutations of FLNA occurred in 33 individuals examined. Heterotopia in the fetal brain revealed cytoarchitectonic characteristics similar to those associated with FLNA mutations; cortical pathology was not typical of polymicrogyria. Cerebellar involvement was more severe and the hippocampi appeared simple and under-rotated.
Conclusions: This series delineates a malformation complex in which PNH in the trigones and occipito-temporal horns is associated with hippocampal, corpus callosum, and cerebellar dysgenesis. This subtype of PNH is distinct from classic PNH caused by FLNA mutations. Neurology (R) 2012;79:1244-1251
C1 [Pisano, Tiziana; Parrini, Elena; Marini, Carla; Guerrini, Renzo] Univ Florence, Childrens Hosp A Meyer, Pediat Neurol & Neurogenet Unit, Florence, Italy.
[Barkovich, A. James] Univ Calif San Francisco, Dept Radiol, San Francisco, CA USA.
[Leventer, Richard J.] Univ Melbourne, Royal Childrens Hosp, Childrens Neurosci Ctr, Murdoch Childrens Res Inst,Dept Paediat, Melbourne, Vic, Australia.
[Squier, Waney] John Radcliffe Hosp, Paediat Neurol Unit, Oxford OX3 9DU, England.
[Scheffer, Ingrid E.; Berkovic, Samuel F.] Univ Melbourne, Epilepsy Res Ctr, Dept Med, Austin Hlth, Melbourne, Vic, Australia.
[Scheffer, Ingrid E.] Univ Melbourne, Royal Childrens Hosp, Dept Paediat, Melbourne, Vic, Australia.
[Blaser, Susan] Univ Toronto, Hosp Sick Children, Toronto, ON M5G 1X8, Canada.
[Robertson, Stephen] Univ Otago, Dept Paediat & Child Hlth, Dunedin Sch Med, Dunedin, New Zealand.
[Tortorella, Gaetano] Univ Hosp Messina, Unit Infantile Neuropsychiat, Dept Med & Surg Pediat, Messina, Italy.
[Rosenow, Felix] Univ Marburg, Epilepsy Ctr Hessen, Dept Neurol, UKGM, D-35032 Marburg, Germany.
[Thomas, Pierre] Hop Louis Pasteur, Serv Neurol, Unite Fonct EEG Epileptol, F-06002 Nice, France.
[McGillivray, George] Royal Childrens Hosp, Murdoch Childrens Res Inst, Genet Hlth Serv Victoria, Melbourne, Vic, Australia.
[Andermann, Eva; Andermann, Frederick] McGill Univ, Neurol Hosp & Inst, Montreal, PQ, Canada.
[Dobyns, William B.] Seattle Childrens Res Inst Ctr Integrat Brain Res, Seattle, WA USA.
[Guerrini, Renzo] Res Inst IRCCS Stella Maris Fdn, Pisa, Italy.
RP Guerrini, R (reprint author), Univ Florence, Childrens Hosp A Meyer, Pediat Neurol & Neurogenet Unit, Florence, Italy.
EM r.guerrini@meyer.it
RI Scheffer, Ingrid/G-1668-2013
OI Scheffer, Ingrid/0000-0002-2311-2174
FU NIH/NINDS; NIH/NIBIB; National Health and Medical Research Council of
Australia; Health Research Council of New Zealand; NIH University of
Melbourne; Austin Health Medical Research Foundation; Brockhoff
Foundation; Perpetual Charitable Trustees; Child Health Research
Foundation; Shepherd Foundation
FX T. Pisano reports no disclosures. A.J. Barkovich receives research
support from NIH/NINDS and NIH/NIBIB. R. Leventer and W. Squier report
no disclosures. I. Scheffer has received honoraria from GlaxoSmithKline,
UCB, Biocodex, Athena Diagnostics, Janssen-Cilag, and Eli Lilly. She has
pending patents entitled: Therapeutic compound: patent number:
61/010176; countries of patent: patent types: application year: 2008.
She has received research support from the National Health and Medical
Research Council of Australia: Health Research Council of New Zealand,
NIH University of Melbourne, Austin Health Medical Research Foundation,
Brockhoff Foundation, Perpetual Charitable Trustees, ANZ Trustees, Child
Health Research Foundation, and Shepherd Foundation. E. Parrini and S.
Blaser report no disclosures. C. Marini has received research support
from Sixth Framework Thematic Priority Life sciences, Genomics and
Biotechnology for Health, the Italian Ministry of Health and Education,
and the Mariani Foundation. S. Robertson and G. Tortorella report no
disclosures. F. Rosenow has received Scientific Advisory Boards from
UCB, GSK, Pfizer, Eisai, and received honoraria from UCB. G. McGillivray
has received honoraria from Roche and works as geneticist at Victorian
Clinical Genetics Service. E. Andermann has received honoraria from UCB
and has received research support from Sunovion Pharma, UCB, Santhera
Pharma, and NINDS/NIH. F. Andermann reports no disclosures relevant to
the manuscript. S. Berkovic was in the Scientific Advisory Boards: UCB
SV2A. He has received honoraria from UCB. He is one of the inventors
listed on a patent held by Bionomics Inc on diagnostic testing of using
the SCN1A gene. He receives research support from UCB, Novartis, Sanofi
Aventis, National Health, and Medical Research Council of Australia. W.
Dobyns receives research support from NIH. R. Guerrini has received
honoraria from Biocodex, UCB, Eisai Inc, ValueBox, and EMA (European
Medicine Agency). He receives research support from the Italian Ministry
of Health, the European Community Sixth Framework Thematic Priority Life
Sciences, Genomics and Biotechnology for Health, the Italian Ministry of
Education, University and Research, the Tuscany Region, the Telethon
Foundation, and the Mariani Foundation. Go to Neurology.org for full
disclosures.
CR Barkovich AJ, 2005, NEUROLOGY, V65, P1873, DOI 10.1212/01.wnl.0000183747.05269.2d
Barkovich AJ, 2010, EPILEPSIA, V51, P17, DOI 10.1111/j.1528-1167.2009.02436.x
Baulac M, 1998, ANN NEUROL, V44, P223, DOI 10.1002/ana.410440213
Dobyns WB, 1996, NEUROLOGY, V47, P331
Eksioglu YZ, 1996, NEURON, V16, P77, DOI 10.1016/S0896-6273(00)80025-2
Elsen Gina E, 2009, Dev Biol, V335, P78, DOI 10.1016/j.ydbio.2009.08.024
Fernandez G, 1998, NEUROLOGY, V50, P909
Fox JW, 1998, NEURON, V21, P1315, DOI 10.1016/S0896-6273(00)80651-0
Gillig Paulette Marie, 2010, Psychiatry (Edgmont), V7, P38
Guerrini R, 2004, NEUROLOGY, V63, P51
Guerrini R, 2008, TRENDS NEUROSCI, V31, P154, DOI 10.1016/j.tins.2007.12.004
Kakita A, 2002, ACTA NEUROPATHOL, V104, P649, DOI 10.1007/s00401-002-0594-9
Larsen KB, 2010, J HISTOCHEM CYTOCHEM, V58, P669, DOI 10.1369/jhc.2010.955757
Li SH, 2008, J NEUROSCI, V28, P5817, DOI 10.1523/JNEUROSCI.0853-08.2008
Parrini E, 2006, BRAIN, V129, P1892, DOI 10.1093/brain/awl125
Poretti A, 2009, EUR J PAEDIATR NEURO, V13, P397, DOI 10.1016/j.ejpn.2008.09.001
Sheen Volney L, 2005, Clin Med Res, V3, P229
Sheen VL, 2001, HUM MOL GENET, V10, P1775, DOI 10.1093/hmg/10.17.1775
Sloan W, 1955, AM J MENT DEF, V60, P258
Sparks BF, 2002, NEUROLOGY, V59, P184
Suzuki H, 2004, FEBS LETT, V573, P214, DOI 10.1016/j.febslet.2004.07.068
Wieck G, 2005, BRAIN, V128, P2811, DOI 10.1093/brain/awh658
NR 22
TC 7
Z9 7
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0028-3878
J9 NEUROLOGY
JI Neurology
PD SEP
PY 2012
VL 79
IS 12
BP 1244
EP 1251
DI 10.1212/WNL.0b013e31826aac88
PG 8
WC Clinical Neurology
SC Neurosciences & Neurology
GA 009WK
UT WOS:000309055900015
PM 22914838
ER
PT J
AU Rosenzweig, I
Vukadinovic, Z
Turner, AJ
Catani, M
AF Rosenzweig, Ivana
Vukadinovic, Zoran
Turner, Anthony J.
Catani, Marco
TI Neuroconnectivity and valproic acid: The myelin hypothesis
SO NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
LA English
DT Review
DE Valproic acid; Myelination; HDAC inhibitors; Autism; Epilepsy;
Cognition; Neuroplasticity; Diffusion imaging
ID JUVENILE MYOCLONIC EPILEPSY; MATTER STRUCTURAL INTEGRITY; WHITE-MATTER;
ANTIEPILEPTIC DRUGS; COGNITIVE DECLINE; EPIGENETIC CONTROL; BRAIN
MYELINATION; PREFRONTAL CORTEX; ALZHEIMER-DISEASE; CHILDREN BORN
AB Neuropsychiatric medications that directly alter the epigenome, such as valproic acid, can under certain conditions reactivate critical developmental periods and thus impact adult neuroconnectivity. In animal models valproic acid was shown to inhibit the process of postnatal myelination and to replicate age-dependent decline in remyelination efficiency. The human central nervous system's myelination process, unlike that of non-human primates commonly used in the experimental models, is an intricate heterochronous process that continues well into adult life and which probably underlies later life neurocognitive changes and plasticity. Chronic exposure to valproic acid, especially in patients with epilepsy and neuropsychiatric disorders, may profoundly affect this process and its developmental trajectory. Further studies using novel MRI methods that allow in vivo mapping of myelination trajectories across the lifespan are urgently required to address the potential effects of valproic acid on brain development. (C) 2012 Elsevier Ltd. All rights reserved.
C1 [Rosenzweig, Ivana] Royal Brompton Hosp, Acad Unit Sleep, London SW3 6NP, England.
[Rosenzweig, Ivana] Royal Brompton Hosp, Dept Psychiat, London SW3 6NP, England.
[Vukadinovic, Zoran] Albert Einstein Coll Med, Dept Psychiat & Behav Sci, Montefiore Med Ctr, Bronx, NY USA.
[Turner, Anthony J.] Univ Leeds, Fac Biol Sci, Inst Mol & Cellular Biol, Leeds, W Yorkshire, England.
[Catani, Marco] Kings Coll London, Inst Psychiat, Dept Forens & Neurodev Sci, NATBRAINLAB, London WC2R 2LS, England.
RP Rosenzweig, I (reprint author), Royal Brompton Hosp, Acad Unit Sleep, Sydney St, London SW3 6NP, England.
EM i.rosenzweig@camprot.com
RI Catani, Marco/H-7801-2012
CR Adab N, 2004, J NEUROL NEUROSUR PS, V75, P1575, DOI 10.1136/jnnp.2003.029132
Arndt TL, 2005, INT J DEV NEUROSCI, V23, P189, DOI 10.1016/j.ijdevneu.2004.11.001
Azorin JM, 2007, CNS DRUGS, V21, P1019, DOI 10.2165/00023210-200721120-00005
Bardai F.H., 2011, J NEUROSCI, V31, P1746
Bartzokis G, 2001, ARCH GEN PSYCHIAT, V58, P461, DOI 10.1001/archpsyc.58.5.461
Bartzokis G, 2003, ARCH NEUROL-CHICAGO, V60, P393, DOI 10.1001/archneur.60.3.393
Bartzokis G, 2004, NEUROBIOL AGING, V25, P5, DOI 10.1016/j.neurobiolaging.2003.03.001
Bartzokis G, 2005, ADOLESCENT PSYCHIAT, V29, P55
Bartzokis G, 2011, FRONT BIOSCI-LANDMRK, V16, P2695, DOI 10.2741/3881
Bartzokis G, 2004, NEUROBIOL AGING, V25, P843, DOI 10.1016/j.neurobiolaging.2003.09.005
Chuang DM, 2009, TRENDS NEUROSCI, V32, P591, DOI 10.1016/j.tins.2009.06.002
D'Ambrosio R, 2004, CURR OPIN NEUROL, V17, P731, DOI 10.1097/00019052-200412000-00014
Deoni SCL, 2011, J NEUROSCI, V31, P784, DOI 10.1523/JNEUROSCI.2106-10.2011
Deppe M, 2008, NEUROLOGY, V71, P1981, DOI 10.1212/01.wnl.0000336969.98241.17
Dietz KC, 2010, PHARMACOL RES, V62, P11, DOI 10.1016/j.phrs.2010.01.011
Eyal S, 2004, EPILEPSIA, V45, P737, DOI 10.1111/j.0013-9580.2004.00104.x
Farkas Z, 2010, SEIZURE-EUR J EPILEP, V19, P173, DOI 10.1016/j.seizure.2010.01.013
Fischer A, 2010, TRENDS PHARMACOL SCI, V31, P605, DOI 10.1016/j.tips.2010.09.003
Fischer A, 2007, NATURE, V447, P178, DOI 10.1038/nature05772
Flechsig P., 2001, J GERONTOL B-PSYCHOL, V158, P1027
Fleisher AS, 2011, NEUROLOGY, V77, P1263, DOI 10.1212/WNL.0b013e318230a16c
Gao W, 2009, AM J NEURORADIOL, V30, P290, DOI 10.3174/ajnr.A1363
Gogolla N, 2009, J NEURODEV DISORD, V1, P172, DOI 10.1007/s11689-009-9023-x
Goldberg JF, 2001, J CLIN PSYCHIAT, V62, P27
Gräff Johannes, 2011, Physiol Rev, V91, P603, DOI 10.1152/physrev.00012.2010
Guerrini R, 1998, EPILEPSIA, V39, P27, DOI 10.1111/j.1528-1157.1998.tb01270.x
Ha TH, 2011, NEUROSCI LETT, V505, P150, DOI 10.1016/j.neulet.2011.10.009
Henry Thomas R, 2003, Psychopharmacol Bull, V37 Suppl 2, P5
Hessen E, 2006, EPILEPSIA, V47, P2038, DOI 10.1111/j.1528-1167.2006.00805.x
Huttenlocher PR, 1997, J COMP NEUROL, V387, P167, DOI 10.1002/(SICI)1096-9861(19971020)387:2<167::AID-CNE1>3.0.CO;2-Z
Jacob C, 2011, MOL NEUROBIOL, V44, P303, DOI 10.1007/s12035-011-8198-9
Kennedy KM, 2009, NEUROPSYCHOLOGIA, V47, P916, DOI 10.1016/j.neuropsychologia.2009.01.001
Kim D, 2008, NEURON, V60, P803, DOI 10.1016/j.neuron.2008.10.015
Kochunov P, 2010, NEUROIMAGE, V49, P1190, DOI 10.1016/j.neuroimage.2009.09.052
Kochunov P, 2012, NEUROBIOL AGING, V33, P9, DOI 10.1016/j.neurobiolaging.2010.01.014
Konrad A, 2009, NEUROPSYCHOBIOLOGY, V60, P55, DOI 10.1159/000236445
LAMANTIA AS, 1990, J COMP NEUROL, V291, P520, DOI 10.1002/cne.902910404
Larrison AL, 2011, HUM PSYCHOPHARM CLIN, V26, P517, DOI 10.1002/hup.1236
LeBlanc JJ, 2011, NEURAL PLAST, DOI 10.1155/2011/921680
Lehrman G, 2005, LANCET, V366, P549, DOI 10.1016/S0140-6736(05)67098-5
Lossius MI, 2008, EPILEPSIA, V49, P455, DOI 10.1111/j.1528-1167.2007.01323.x
Macritchie K., 2003, COCHRANE DB SYST REV, DOI DOI 10.1002/14651858.CD004052
Meador KJ, 2009, NEW ENGL J MED, V360, P1597, DOI 10.1056/NEJMoa0803531
Monti Barbara, 2009, Curr Mol Pharmacol, V2, P95
Nalivaeva N.N., 2011, J MOL NEUROSCIENCE
Nalivaeva NN, 2009, TRENDS PHARMACOL SCI, V30, P509, DOI 10.1016/j.tips.2009.07.002
O'Muircheartaigh J, 2011, NEUROLOGY, V76, P34, DOI 10.1212/WNL.0b013e318203e93d
Peleg S, 2010, SCIENCE, V328, P753, DOI 10.1126/science.1186088
Perucca E, 2002, CNS DRUGS, V16, P695, DOI 10.2165/00023210-200216100-00004
Petanjek Z, 2011, P NATL ACAD SCI USA, V108, P13281, DOI 10.1073/pnas.1105108108
Price JL, 2010, NEUROPSYCHOPHARMACOL, V35, P192, DOI 10.1038/npp.2009.104
Pulsipher DT, 2011, NEUROLOGY, V76, P28, DOI 10.1212/WNL.0b013e318203e8f3
Putignano E, 2007, NEURON, V53, P747, DOI 10.1016/j.neuron.2007.02.007
Rakic P., 2002, CHILD ADOL PSYCH CL, P22
Rinaldi T, 2008, CEREB CORTEX, V18, P763, DOI 10.1093/cercor/bhm117
Ristic AJ, 2006, EPILEPSIA, V47, P2183, DOI 10.1111/j.1528-1167.2006.00711.x
Rosenberg G, 2007, CELL MOL LIFE SCI, V64, P2090, DOI 10.1007/s00018-007-7079-x
Salthouse TA, 2009, NEUROBIOL AGING, V30, P507, DOI 10.1016/j.neurobiolaging.2008.09.023
Schwarz C., 2010, COCHRANE LIB, V5, P1
Shen SM, 2008, NAT NEUROSCI, V11, P1024, DOI 10.1038/nn.2172
Shen SM, 2005, J CELL BIOL, V169, P577, DOI 10.1083/jcb.200412101
Shorvon SD, 2004, J NEUROL NEUROSUR PS, V75, P1517, DOI 10.1136/jnnp.2004.050641
Thomson AM, 2003, CEREB CORTEX, V13, P5, DOI 10.1093/cercor/13.1.5
Vega WA, 2002, DRUG ALCOHOL DEPEN, V68, P285, DOI 10.1016/S0376-8716(02)00224-7
Vernooij MW, 2009, ARCH GEN PSYCHIAT, V66, P545, DOI 10.1001/archgenpsychiatry.2009.5
Vollmar C., 2011, BRAIN 6, V134, P1709
Vostrikov VM, 2007, SCHIZOPHR RES, V94, P273, DOI 10.1016/j.schres.2007.01.014
Vukadinovic Z, 2012, NEUROSCI BIOBEHAV R, V36, P960, DOI 10.1016/j.neubiorev.2011.11.005
Vulliemoz S, 2011, EPILEPSIA, V52, P507, DOI 10.1111/j.1528-1167.2010.02770.x
Washburn JJ, 2011, MINERVA PSICHIATRICA, V52, P21
Yu Y, 2010, EPIGENETICS-US, V5, P124
Zhang B, 2010, CELL MOL NEUROBIOL, V30, P137, DOI 10.1007/s10571-009-9438-7
NR 72
TC 10
Z9 10
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0149-7634
J9 NEUROSCI BIOBEHAV R
JI Neurosci. Biobehav. Rev.
PD SEP
PY 2012
VL 36
IS 8
BP 1848
EP 1856
DI 10.1016/j.neubiorev.2012.05.006
PG 9
WC Behavioral Sciences; Neurosciences
SC Behavioral Sciences; Neurosciences & Neurology
GA 010MM
UT WOS:000309098500004
PM 22652270
ER
PT J
AU Salafia, C
Misra, D
Golding, J
Platt, C
Yampolsky, M
Shlakhter, O
Ring, S
AF Salafia, Carolyn
Misra, Dawn
Golding, Jean
Platt, Craig
Yampolsky, Michael
Shlakhter, Oleksandr
Ring, Sue
TI ANALYSIS OF PLACENTAL SHAPE AND CORD INSERTION IN A RELATED COHORT OF
FAMILIAL AUTISM, THE EARLI COHORT
SO PLACENTA
LA English
DT Meeting Abstract
CT Meeting of the International-Federation-of-Placenta-Associations (IFPA)
CY SEP 18-21, 2012
CL Hiroshima, JAPAN
SP Int Federat Placenta Assoc (IFPA)
C1 [Salafia, Carolyn; Ring, Sue] Placental Analyt LLC, Larchmont, NY USA.
[Misra, Dawn] Wayne State Univ, Sch Med, Detroit, MI USA.
[Golding, Jean] Univ Bristol, Sch Social & Community Med, Bristol, Avon, England.
[Platt, Craig] Univ Hosp Bristol NHS Fdn Trust, Bristol, Avon, England.
[Yampolsky, Michael; Shlakhter, Oleksandr] Univ Toronto, Toronto, ON, Canada.
RI Platt, Craig/C-5137-2012
NR 0
TC 0
Z9 0
PU W B SAUNDERS CO LTD
PI LONDON
PA 32 JAMESTOWN RD, LONDON NW1 7BY, ENGLAND
SN 0143-4004
J9 PLACENTA
JI Placenta
PD SEP
PY 2012
VL 33
IS 9
BP A16
EP A16
PG 1
WC Developmental Biology; Obstetrics & Gynecology; Reproductive Biology
SC Developmental Biology; Obstetrics & Gynecology; Reproductive Biology
GA 007NV
UT WOS:000308896300045
ER
PT J
AU Salafia, C
Misra, D
Golding, J
Platt, C
Ring, S
AF Salafia, Carolyn
Misra, Dawn
Golding, Jean
Platt, Craig
Ring, Sue
TI CHARACTERIZATION OF PLACENTAL GROWTH AS A BIOMARKER OF AUTISM/ASD RISK
SO PLACENTA
LA English
DT Meeting Abstract
CT Meeting of the International-Federation-of-Placenta-Associations (IFPA)
CY SEP 18-21, 2012
CL Hiroshima, JAPAN
SP Int Federat Placenta Assoc (IFPA)
C1 [Salafia, Carolyn; Ring, Sue] Placental Analyt LLC, Larchmont, NY USA.
[Misra, Dawn] Wayne State Univ, Sch Med, Detroit, MI USA.
[Golding, Jean] Univ Bristol, Sch Social & Community Med, Bristol, Avon, England.
[Platt, Craig] Univ Hosp Bristol NHS Fdn Trust, Bristol, Avon, England.
RI Platt, Craig/C-5137-2012
NR 0
TC 0
Z9 0
PU W B SAUNDERS CO LTD
PI LONDON
PA 32 JAMESTOWN RD, LONDON NW1 7BY, ENGLAND
SN 0143-4004
J9 PLACENTA
JI Placenta
PD SEP
PY 2012
VL 33
IS 9
BP A16
EP A16
PG 1
WC Developmental Biology; Obstetrics & Gynecology; Reproductive Biology
SC Developmental Biology; Obstetrics & Gynecology; Reproductive Biology
GA 007NV
UT WOS:000308896300044
ER
PT J
AU Kim, JS
Jung, WH
Kang, DH
Park, JY
Jang, JH
Choi, JS
Choi, CH
Kim, J
Kwon, JS
AF Kim, Joon Shik
Jung, Wi Hoon
Kang, Do-Hyung
Park, Ji-Young
Jang, Joon Hwan
Choi, Jung-Seok
Choi, Chi-Hoon
Kim, Jejoong
Kwon, Jun Soo
TI Changes in Effective Connectivity According to Working Memory Load: An
fMRI Study of Face and Location Working Memory Tasks
SO PSYCHIATRY INVESTIGATION
LA English
DT Article
DE Face matching; Functional magnetic resonance imaging; Location matching;
Structural equation modeling; Working memory
ID COORDINATE SPATIAL RELATIONS; FUNCTIONAL INTERACTIONS; PET
INVESTIGATIONS; NEURAL SYSTEMS; PATH-ANALYSIS; PARIETAL; CORTEX; OBJECT;
AUTISM; BACK
AB Objective The functional strategic mechanisms in the brain during performing visuospatial working memory tasks, especially tasks with heavy load, are controversial. We conducted the functional magnetic resonance imaging (fMRI) while sixteen subjects were performing face- and location-matching n-back tasks to examine causal relations within the frontoparietal networks.
Methods We applied a sophisticated method, the structural equation modeling (SEM), to the fMRI data. The imaging data were analyzed by extracting the task-related eigenseries using the principal component analysis (PCA) and then by applying a form of data-driven model called the automated search method.
Results The SEM analyses revealed a functional shift of network connectivity from the right to the left hemisphere with increasing load in the face-matching n-back tasks while the location-matching tasks required bilateral activation. In the locating matching n-back tasks, a pattern of parallel processing was observed in the left phonological loop and the right inferior parietal regions. Furthermore, object working memory-related activities in the left hemisphere reliably contributed to performance of both the face- and location-matching 2-back tasks.
Conclusion Our results are consistent with previous reports in terms of demonstrating parallel and distributed information processing during performing working memory tasks with heavy loads. Our results additionally suggest a dynamic shift between the fast imagery circuit (right hemisphere) and the stable verbal circuit (left hemisphere), depending on task load. Psychiatry Investig 2012;9:283-292
C1 [Kim, Joon Shik; Jung, Wi Hoon; Park, Ji-Young; Kwon, Jun Soo] SNU MRC, Inst Human Behav Med, Seoul, South Korea.
[Kang, Do-Hyung; Jang, Joon Hwan; Choi, Jung-Seok; Kwon, Jun Soo] Seoul Natl Univ, Dept Psychiat, Coll Med, Seoul 110744, South Korea.
[Choi, Chi-Hoon] Natl Med Ctr, Dept Diagnost Radiol, Seoul, South Korea.
[Kim, Jejoong] Duksung Womens Univ, Dept Psychol, Seoul, South Korea.
[Kim, Jejoong; Kwon, Jun Soo] Seoul Natl Univ, Dept Brain & Cognit Sci, World Class Univ Program, Coll Nat Sci, Seoul 110744, South Korea.
RP Kwon, JS (reprint author), Seoul Natl Univ, Dept Psychiat & Behav Sci, Coll Med, 101 Daehak Ro, Seoul 110744, South Korea.
EM kwonjs@snu.ac.kr
RI Kwon, Jun Soo/J-2734-2012; Kang, Do-Hyung/J-5358-2012; Park,
Ji-Young/C-1331-2015
FU National Research Foundation of Korea (NRF); Ministry of Education,
Science and Technology [2009-0074054]; Brain Korea 21 Project
FX We thank Yong-Sik Jung and Ji Yeon Han for their technical assistance
and data collection, respectively. This work was supported by the Basic
Science Research Program through the National Research Foundation of
Korea (NRF) funded by the Ministry of Education, Science and Technology
(2009-0074054). Also, this study was supported by the Brain Korea 21
Project in 2012.
CR Arbuckle JL, 2007, AMOS 16 0 USERS GUID
Baddeley A, 2003, NAT REV NEUROSCI, V4, P829, DOI 10.1038/nrn1201
Baddeley A. D., 1986, WORKING MEMORY
BRANDIMONTE MA, 1993, MEM COGNITION, V21, P23, DOI 10.3758/BF03211161
Bullmore ET, 2000, NEUROIMAGE, V11, P289, DOI 10.1006/nimg.2000.0544
Corbetta M, 2000, NAT NEUROSCI, V3, P292, DOI 10.1038/73009
Courtney SM, 1997, NATURE, V386, P608, DOI 10.1038/386608a0
Glabus MF, 2003, CEREB CORTEX, V13, P1352, DOI 10.1093/cercor/bhg082
Haxby JV, 1995, HUM BRAIN MAPP, V3, P68, DOI 10.1002/hbm.460030204
Honey GD, 2002, NEUROIMAGE, V17, P573, DOI 10.1006/nimg.2002.1193
Horwitz B, 1999, TRENDS COGN SCI, V3, P91, DOI 10.1016/S1364-6613(99)01282-6
JONIDES J, 1993, NATURE, V363, P623, DOI 10.1038/363623a0
Kim JJ, 2003, AM J PSYCHIAT, V160, P919, DOI 10.1176/appi.ajp.160.5.919
Koshino H, 2008, CEREB CORTEX, V18, P289, DOI 10.1093/cercor/bhm054
Koshino H, 2005, NEUROIMAGE, V24, P810, DOI 10.1016/j.neuroimage.2004.09.028
Kosslyn SM, 1998, PSYCHOBIOLOGY, V26, P333
KOSSLYN SM, 1992, J EXP PSYCHOL HUMAN, V18, P562, DOI 10.1037/0096-1523.18.2.562
Marvel CL, 2010, CORTEX, V46, P880, DOI 10.1016/j.cortex.2009.08.017
Maurer D, 2007, NEUROPSYCHOLOGIA, V45, P1438, DOI 10.1016/j.neuropsychologia.2006.11.016
McIntosh AR, 1996, CEREB CORTEX, V6, P571, DOI 10.1093/cercor/6.4.571
MCINTOSH AR, 1994, J NEUROSCI, V14, P655
Nobre AC, 1997, BRAIN, V120, P515, DOI 10.1093/brain/120.3.515
Owen AM, 2005, HUM BRAIN MAPP, V25, P46, DOI 10.1002/hbm.20131
Passarotti AM, 2003, DEVELOPMENTAL SCI, V6, P100, DOI 10.1111/1467-7687.00259
Sala JB, 2007, CORTEX, V43, P5, DOI 10.1016/S0010-9452(08)70442-8
SMITH EE, 1995, J COGNITIVE NEUROSCI, V7, P337, DOI 10.1162/jocn.1995.7.3.337
Tomasi D, 2007, BRAIN RES, V1132, P158, DOI 10.1016/j.brainres.2006.11.030
Tsubomi H, 2009, NEUROIMAGE, V45, P587, DOI 10.1016/j.neuroimage.2008.11.028
WILSON FAW, 1993, SCIENCE, V260, P1955, DOI 10.1126/science.8316836
NR 29
TC 3
Z9 3
PU KOREAN NEUROPSYCHIATRIC ASSOC
PI SEOUL
PA RN 522, G-FIVE CENTRAL PLAZA 1685-8 SEOCHO 4-DONG, SEOCHO-GU, SEOUL,
137-882, SOUTH KOREA
SN 1738-3684
J9 PSYCHIAT INVEST
JI Psychiatry Investig.
PD SEP
PY 2012
VL 9
IS 3
BP 283
EP 292
DI 10.4306/pi.2012.9.3.283
PG 10
WC Psychiatry
SC Psychiatry
GA 009QX
UT WOS:000309041400013
PM 22993529
ER
PT J
AU Rahbar, MH
Samms-Vaughan, M
Ardjomand-Hessabi, M
Loveland, KA
Dickerson, AS
Chen, ZX
Bressler, J
Shakespeare-Pellington, S
Grove, ML
Bloom, K
Wirth, J
Pearson, DA
Boerwinkle, E
AF Rahbar, Mohammad H.
Samms-Vaughan, Maureen
Ardjomand-Hessabi, Manouchehr
Loveland, Katherine A.
Dickerson, Aisha S.
Chen, Zhongxue
Bressler, Jan
Shakespeare-Pellington, Sydonnie
Grove, Megan L.
Bloom, Kari
Wirth, Julie
Pearson, Deborah A.
Boerwinkle, Eric
TI The role of drinking water sources, consumption of vegetables and
seafood in relation to blood arsenic concentrations of Jamaican children
with and without Autism Spectrum Disorders
SO SCIENCE OF THE TOTAL ENVIRONMENT
LA English
DT Article
DE Arsenic; Autism Spectrum Disorders; Vegetables; Drinking water; Seafood;
Jamaica
ID NATIVE ANDEAN WOMEN; NORTH-SEA FISH; GASTROINTESTINAL SYMPTOMS; FOOD
SELECTIVITY; RISK-ASSESSMENT; EXPOSURE; POPULATION; BANGLADESH; CHINA;
HAIR
AB Arsenic is a toxic metal with harmful effects on human health, particularly on cognitive function. Autism Spectrum Disorders (ASDs) are lifelong neurodevelopmental and behavioral disorders manifesting in infancy or early childhood. We used data from 130 children between 2 and 8 years (65 pairs of ASD cases with age- and sex-matched control), to compare the mean total blood arsenic concentrations in children with and without ASDs in Kingston, Jamaica. Based on univariable analysis, we observed a significant difference between ASD cases and controls (4.03 mu g/L for cases vs. 4.48 mu g/L for controls. P<0.01). In the final multivariable General Linear Model (GLM), after controlling for car ownership, maternal age, parental education levels, source of drinking water, consumption of "yam, sweet potato, or dasheen", "carrot or pumpkin", "callaloo, broccoli, or pak choi", cabbage, avocado, and the frequency of seafood consumption per week, we did not find a significant association between blood arsenic concentrations and ASD status (4.36 mu g/L for cases vs. 4.65 mu g/L for controls. P=0.23). Likewise, in a separate final multivariable GLM, we found that source of drinking water, eating avocado, and eating "callaloo, broccoli, or pak choi" was significantly associated with higher blood arsenic concentrations (all three P<0.05). Based on our findings, we recommend assessment of arsenic levels in water, fruits, and vegetables, as well as increased awareness among the Jamaican population regarding potential risks for various exposures to arsenic. (C) 2012 Elsevier B.V. All rights reserved.
C1 [Rahbar, Mohammad H.] Univ Texas Hlth Sci Ctr Houston, Biostat Epidemiol Res Design Component Ctr Clin &, Sch Publ Hlth, Div Epidemiol Human Genet & Environm Sci, Houston, TX 77030 USA.
[Rahbar, Mohammad H.; Ardjomand-Hessabi, Manouchehr; Chen, Zhongxue; Bloom, Kari] Univ Texas Hlth Sci Ctr Houston, Ctr Clin & Translat Sci, Biostat Epidemiol Res Design Core, Houston, TX 77030 USA.
[Samms-Vaughan, Maureen; Shakespeare-Pellington, Sydonnie] Univ W Indies, Dept Child Hlth, Kingston 7, Jamaica.
[Loveland, Katherine A.; Pearson, Deborah A.] Univ Texas Hlth Sci Ctr Houston, Sch Med, Dept Psychiat & Behav Sci, Houston, TX 77030 USA.
[Loveland, Katherine A.] Univ Texas Hlth Sci Ctr Houston, Ctr Excellence Dev & Psychopathol, Dept Psychiat & Behav Sci, Changing Lives Autism Spectrum Serv Clin, Houston, TX 77030 USA.
[Bressler, Jan; Grove, Megan L.; Boerwinkle, Eric] Univ Texas Hlth Sci Ctr Houston, Ctr Human Genet, Sch Publ Hlth, Houston, TX 77030 USA.
[Wirth, Julie] Michigan State Univ, Dept Epidemiol, E Lansing, MI 48824 USA.
RP Rahbar, MH (reprint author), Univ Texas Hlth Sci Ctr Houston, Biostat Epidemiol Res Design Component Ctr Clin &, Sch Publ Hlth, Div Epidemiol Human Genet & Environm Sci, 6410 Fannin St,UT Profess Bldg,Suite 1100-05, Houston, TX 77030 USA.
EM Mohammad.H.Rahbar@uth.tmc.edu; msamms@cwjamaica.com;
Manouchehr.A.Hessabi@uth.tmc.edu; Katherine.A.Loveland@uth.tmc.edu;
Aisha.S.Dickerson@uth.tmc.edu; Zhongxue.Chen@uth.tmc.edu;
Jan.Bressler@uth.tmc.edu; sydonniesp@gmail.com;
Megan.L.Grove@uth.tmc.edu; Kari.Bloom@uth.tmc.edu; wirthj@msu.edu;
Deborah.A.Pearson@uth.tmc.edu; Eric.Boerwinkle@uth.tmc.edu
RI Chen, Zhongxue/K-1372-2013
OI Chen, Zhongxue/0000-0003-2537-7843
FU Eunice Kennedy Shriver National Institute of Child Health and Human
Development (NICHD); National Institutes of Health Fogarty International
Center (NIH-FIC) [R21HD057808]; Biostatistics/Epidemiology/Research
Design (BERD) component of the Center for Clinical and Translational
Sciences (CCTS); NIH Centers for Translational Science Award (NIH CTSA)
by the National Center for Research Resources (NCRR) [UL1 RR024148]
FX This research is co-funded by the Eunice Kennedy Shriver National
Institute of Child Health and Human Development (NICHD) and the National
Institutes of Health Fogarty International Center (NIH-FIC) by a grant
[R21HD057808] awarded to the University of Texas Health Science Center
at Houston (UTHealth). We also acknowledge the support provided by the
Biostatistics/Epidemiology/Research Design (BERD) component of the
Center for Clinical and Translational Sciences (CCTS) for this project.
CCTS is mainly funded by the NIH Centers for Translational Science Award
(NIH CTSA) grant (UL1 RR024148), awarded to the University of Texas
Health Science Center at Houston in 2006 by the National Center for
Research Resources (NCRR). The content is solely the responsibility of
the authors and does not necessarily represent the official views of the
NICHD or the NIH-FIC or the NCRR. Finally, we acknowledge contributions
by colleagues in the Trace Metals Lab at MDCH for analyzing and storing
the blood samples for arsenic concentrations.
CR Abernathy CO, 2003, J NUTR, V133, p1536S
American Psychiatric Association, 2000, DIAGN STAT MAN MENT
ATSDR, 2007, TOXGUIDE ARS
ATSDR, 2010, WHO IS RISK OV ARS
ATSDR, 2007, TOX PROF ARS
Baeyens W, 2009, MOL NUTR FOOD RES, V53, P558, DOI 10.1002/mnfr.200700533
Beesley L, 2010, ENVIRON POLLUT, V158, P2282, DOI 10.1016/j.envpol.2010.02.003
Borak J, 2007, REGUL TOXICOL PHARM, V47, P204, DOI 10.1016/j.yrtph.2006.09.005
Calderon J, 2001, ENVIRON RES, V85, P69, DOI 10.1006/enrs.2000.4106
Caussy D., 2005, FIELD GUIDE DETECTIO
Cermak SA, 2010, J AM DIET ASSOC, V110, P238, DOI 10.1016/j.jada.2009.10.032
Chen C, 2011, J FOOD SCI, V76, pT181, DOI 10.1111/j.1750-3841.2011.02341.x
Concha G, 1998, INT ARCH OCC ENV HEA, V71, P42, DOI 10.1007/s004200050248
De Gieter M, 2002, ARCH ENVIRON CON TOX, V43, P406, DOI 10.1007/s00244-002-1193-4
Elliott C, 2009, INVESTIGATION ELEVAT
Fido A, 2005, AUTISM, V9, P290, DOI 10.1177/1362361305053255
Gale CR, 2009, J CHILD PSYCHOL PSYC, V50, P816, DOI 10.1111/j.1469-7610.2008.02029.x
Gardener H, 2011, PEDIATRICS, V128, P344, DOI 10.1542/peds.2010-1036
Genuis SJ, 2009, ACTA PAEDIATR, V98, P1575, DOI 10.1111/j.1651-2227.2009.01495.x
Hall M, 2006, TOXICOLOGY, V225, P225, DOI 10.1016/j.tox.2006.06.010
Hallmayer J, 2011, ARCH GEN PSYCHIAT, V68, P1095, DOI 10.1001/archgenpsychiatry.2011.76
Hanh HT, 2011, J ENVIRON MONITOR, V13, P2025, DOI 10.1039/c1em10037h
Hertz-Picciotto I, 2010, ENVIRON HEALTH PERSP, V118, P161, DOI 10.1289/ehp.0900736
Hoque BA, 2000, PUBLIC HEALTH, V114, P488, DOI 10.1038/sj.ph.1900707
Horvath K, 2002, CURR OPIN PEDIATR, V14, P583, DOI 10.1097/01.MOP.0000030221.71203.46
Howe A, 2005, ENVIRON GEOCHEM HLTH, V27, P19, DOI 10.1007/s10653-004-5671-7
Ibrahim SH, 2009, PEDIATRICS, V124, P680, DOI 10.1542/peds.2008-2933
Kern JK, 2007, J TOXICOL ENV HEAL A, V70, P715, DOI 10.1080/15287390601188060
Kumar RA, 2009, CURR NEUROL NEUROSCI, V9, P188, DOI 10.1007/s11910-009-0029-2
Laizu J., 2007, BANGL J PHARMACOL, V2, P88
Lalor G, 1999, ENVIRON GEOCHEM HLTH, V21, P3, DOI 10.1023/A:1006542311014
Lalor GC, 1996, ENVIRON GEOCHEM HLTH, V18, P89, DOI 10.1007/BF01771284
Lando AM, 2011, ENVIRON RES, V111, P442, DOI 10.1016/j.envres.2011.01.004
Landrigan PJ, 2010, CURR OPIN PEDIATR, V22, P219, DOI 10.1097/MOP.0b013e328336eb9a
Lopez O, 2011, RSC GREEN CHEM SER, P53
Lord C, 1997, J AUTISM DEV DISORD, V27, P501, DOI 10.1023/A:1025873925661
Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
Lord C., 2002, AUTISM DIAGNOSTIC OB
Mandal BK, 2002, TALANTA, V58, P201, DOI 10.1016/S0039-9140(02)00268-0
Milton AH, 2005, EPIDEMIOLOGY, V16, P82, DOI 10.1097/01.ede.0000147105.94041.e6
Mulligan A, 2009, IRISH J MED SCI, V178, P193, DOI 10.1007/s11845-008-0184-5
Murunga E, 2007, ENV OCCUPATIONAL MED, P800
Obrenovich ME, 2011, BIOL TRACE ELEM RES, V144, P475, DOI 10.1007/s12011-011-9146-2
Oken E, 2005, ENVIRON HEALTH PERSP, V113, P1376, DOI 10.1289/ehp.8041
Palmer RF, 2010, PEDIATRICS, V126
Pesticides Control Authority, 1999, JAMAICA GAZETTE
Rahbar MH, 2012, J AUTISM DEV DISORD
Rahbar M.H., 2012, NEUROTOX RES
Rapin I, 1997, NEW ENGL J MED, V337, P97, DOI 10.1056/NEJM199707103370206
Reigart JR, 1999, RECOGNITION MANAGEME
Rosado JL, 2007, ENVIRON HEALTH PERSP, V115, P1371, DOI 10.1289/ehp.9961
Rutter M., 2003, AUTISM DIAGNOSTIC IN
Rutter M., 2003, SOCIAL COMMUNICATION
Sarker MMR, 2011, INT J ENV SCI DEV, P2
SAS Institute Inc, 2008, SAS 9 2
SCHOPLER E, 1980, J AUTISM DEV DISORD, V10, P91, DOI 10.1007/BF02408436
Schreck KA, 2006, RES DEV DISABIL, V27, P353, DOI 10.1016/j.ridd.2005.03.005
Subcommittee on Arsenic in Drinking Water NRC, 1999, ARS DRINK WAT
Sun GF, 2006, J HEALTH POPUL NUTR, V24, P176
Tong I S, 2001, Ann Epidemiol, V11, P38
USEPA, 1997, ARS FISH CONS
USEPA, 2002, IMPL GUID ARS RUL DR
USEPA, 2009, PEST NEWS STOR ORG A
Vahidnia A, 2007, HUM EXP TOXICOL, V26, P823, DOI 10.1177/0960327107084539
VAHTER M, 1995, EUR J PHARM-ENVIRON, V293, P455, DOI 10.1016/S0014-2999(95)80104-9
Valicenti-McDermott M, 2006, J DEV BEHAV PEDIATR, V27, pS128, DOI 10.1097/00004703-200604002-00011
Vieira C, 2011, FOOD CHEM TOXICOL, V49, P923, DOI 10.1016/j.fct.2010.12.016
Vinot N, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0020491
Volkmar FR, 2008, WORLD PSYCHIATRY, V7, P19
Wang SX, 2007, ENVIRON HEALTH PERSP, V115, P643, DOI 10.1289/ehp.9270
Wasserman GA, 2004, ENVIRON HEALTH PERSP, V112, P1329, DOI 10.1289/ehp.6964
WHO, 2010, COUNTR COOP STRAT CC
WHO, 2001, ENV HLTH CRIT
Wickre JB, 2004, ARCH ENVIRON HEALTH, V59, P400, DOI 10.3200/AEOH.59.8.400-409
World Health Organization, 2010, EXP ARS MAJ PUBL HLT
Wright RO, 2006, NEUROTOXICOLOGY, V27, P210, DOI 10.1016/j.neuro.2005.10.001
Wu MM, 2001, ENVIRON HEALTH PERSP, V109, P1011, DOI 10.2307/3454955
NR 77
TC 9
Z9 9
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0048-9697
J9 SCI TOTAL ENVIRON
JI Sci. Total Environ.
PD SEP 1
PY 2012
VL 433
BP 362
EP 370
DI 10.1016/j.scitotenv.2012.06.085
PG 9
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA 005ZA
UT WOS:000308787500039
PM 22819887
ER
PT J
AU Halgren, C
Kjaergaard, S
Bak, M
Hansen, C
El-Schich, Z
Anderson, CM
Henriksen, KF
Hjalgrim, H
Kirchhoff, M
Bijlsma, EK
Nielsen, M
den Hollander, NS
Ruivenkamp, CAL
Isidor, B
Le Caignec, C
Zannolli, R
Mucciolo, M
Renieri, A
Mari, F
Anderlid, BM
Andrieux, J
Dieux, A
Tommerup, N
Bache, I
AF Halgren, C.
Kjaergaard, S.
Bak, M.
Hansen, C.
El-Schich, Z.
Anderson, C. M.
Henriksen, K. F.
Hjalgrim, H.
Kirchhoff, M.
Bijlsma, E. K.
Nielsen, M.
den Hollander, N. S.
Ruivenkamp, C. A. L.
Isidor, B.
Le Caignec, C.
Zannolli, R.
Mucciolo, M.
Renieri, A.
Mari, F.
Anderlid, B-M
Andrieux, J.
Dieux, A.
Tommerup, N.
Bache, I.
TI Corpus callosum abnormalities, intellectual disability, speech
impairment, and autism in patients with haploinsufficiency of ARID1B
SO CLINICAL GENETICS
LA English
DT Article
DE ARID1B; autism spectrum disorder; chromosome 6q25; corpus callosum;
intellectual disability; next-generation mate-pair sequencing; speech
impairment; translocation
ID MICRODELETION SYNDROME; INTERSTITIAL DELETION; AGENESIS; REGION; GENE
AB Corpus callosum abnormalities are common brain malformations with a wide clinical spectrum ranging from severe intellectual disability to normal cognitive function. The etiology is expected to be genetic in as much as 30-50% of the cases, but the underlying genetic cause remains unknown in the majority of cases. By next-generation mate-pair sequencing we mapped the chromosomal breakpoints of a patient with a de novo balanced translocation, t(1; 6)(p31; q25), agenesis of corpus callosum (CC), intellectual disability, severe speech impairment, and autism. The chromosome 6 breakpoint truncated ARID1B which was also truncated in a recently published translocation patient with a similar phenotype. Quantitative polymerase chain reaction (Q-PCR) data showed that a primer set proximal to the translocation showed increased expression of ARID1B, whereas primer sets spanning or distal to the translocation showed decreased expression in the patient relative to a non-related control set. Phenotype-genotype comparison of the translocation patient to seven unpublished patients with various sized deletions encompassing ARID1B confirms that haploinsufficiency of ARID1B is associated with CC abnormalities, intellectual disability, severe speech impairment, and autism. Our findings emphasize that ARID1B is important in human brain development and function in general, and in the development of CC and in speech development in particular.
C1 [Halgren, C.; Bak, M.; Hansen, C.; El-Schich, Z.; Anderson, C. M.; Henriksen, K. F.; Tommerup, N.; Bache, I.] Univ Copenhagen, Fac Hlth Sci, Wilhelm Johannsen Ctr Funct Genome Res, Dept Cellular & Mol Med, DK-2200 Copenhagen, Denmark.
[Kjaergaard, S.; Kirchhoff, M.] Rigshosp, Univ Copenhagen Hosp, Dept Clin Genet, DK-2100 Copenhagen, Denmark.
[Hjalgrim, H.] Klin Born, Copenhagen, Denmark.
[Bijlsma, E. K.; Nielsen, M.; den Hollander, N. S.; Ruivenkamp, C. A. L.] Leiden Univ, Dept Clin Genet, Med Ctr, Leiden, Netherlands.
[Isidor, B.; Le Caignec, C.] CHU Nantes, Serv Genet Med, F-44035 Nantes 01, France.
[Zannolli, R.] Univ Siena, Dept Pediat, I-53100 Siena, Italy.
[Mucciolo, M.; Renieri, A.; Mari, F.] Univ Siena, Dept Biotechnol, I-53100 Siena, Italy.
[Anderlid, B-M] Karolinska Univ Hosp, Dept Clin Genet, Stockholm, Sweden.
[Andrieux, J.] CHRU Lille, Hop Jeanne de Flandre, Inst Med Genet, Lille, France.
[Dieux, A.] CHRU Lille, Clin Genet Med, Lille, France.
RP Halgren, C (reprint author), Univ Copenhagen, Fac Hlth Sci, Wilhelm Johannsen Ctr Funct Genome Reseach, Dept Cellular & Mol Med, Blegdamsvej 3,24-4-14, DK-2200 Copenhagen, Denmark.
EM halgren@sund.ku.dk
RI Mari, Francesca/E-7737-2012
OI Mari, Francesca/0000-0003-1992-1654
FU Danish National Research Foundation; Lundbeck Foundation; Telethon
Genetic Biobank Network [GTB07001C]
FX This work was supported by the Danish National Research Foundation, the
Lundbeck Foundation, and 'Cell Lines and DNA Bank of Rett syndrome, X
mental retardation and other genetic diseases' (Medical Genetics-Siena)
- Telethon Genetic Biobank Network (Project No. GTB07001C to AR).
CR Backx L, 2011, CYTOGENET GENOME RES, V132, P135, DOI 10.1159/000321577
Bedeschi MF, 2006, PEDIATR NEUROL, V34, P186, DOI 10.1016/j.pediatrneurol.2005.08.008
Dobyns WB, 1996, AM J HUM GENET, V58, P7
Firth HV, 2009, AM J HUM GENET, V84, P524, DOI 10.1016/j.ajhg.2009.03.010
Glass HC, 2008, AM J MED GENET A, V146A, P2495, DOI 10.1002/ajmg.a.32418
Langmead B, 2009, GENOME BIOL, V10, DOI 10.1186/gb-2009-10-3-r25
Li XS, 2010, MOL CELL BIOL, V30, P1673, DOI 10.1128/MCB.00540-09
Mangione R, 2011, ULTRASOUND OBST GYN, V37, P290, DOI 10.1002/uog.8882
Nagamani SCS, 2009, EUR J HUM GENET, V17, P573, DOI 10.1038/ejhg.2008.220
Nagl NG, 2007, EMBO J, V26, P752, DOI 10.1038/sj.emboj.7601541
Nord AS, 2011, EUR J HUM GENET, V30, P1
O'Driscoll MC, 2010, AM J MED GENET A, V152A, P2145, DOI 10.1002/ajmg.a.33558
Ovcharenko I, 2005, GENOME RES, V15, P137, DOI 10.1101/gr.3015505
Paul LK, 2007, NAT REV NEUROSCI, V8, P287, DOI 10.1038/nrn2107
Pirola B, 1998, J MED GENET, V35, P1031, DOI 10.1136/jmg.35.12.1031
Rubtsov N, 1996, HUM GENET, V97, P705
Schell-Apacik CC, 2008, AM J MED GENET A, V146A, P2501, DOI 10.1002/ajmg.a.32476
van Bon BWM, 2008, J MED GENET, V45, P346, DOI 10.1136/jmg.2007.055830
Vandesompele J, 2002, GENOME BIOL, V3, DOI 10.1186/gb-2002-3-7-research0034
Wang LW, 2004, NEURORADIOLOGY, V46, P368, DOI 10.1007/s00234-003-1160-4
Yan Z, 2008, STEM CELLS, V26, P1155, DOI 10.1634/stemcells.2007-0846
NR 21
TC 24
Z9 24
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0009-9163
J9 CLIN GENET
JI Clin. Genet.
PD SEP
PY 2012
VL 82
IS 3
BP 248
EP 255
DI 10.1111/j.1399-0004.2011.01755.x
PG 8
WC Genetics & Heredity
SC Genetics & Heredity
GA 003XX
UT WOS:000308645800009
PM 21801163
ER
PT J
AU Frye, RE
Frye, RE
Rose, S
James, SJ
AF Frye, Richard E.
Frye, Richard E.
Rose, Shannon
James, S. Jill
TI Children with mitochondrial disease and autism have alterations in
pathways involved in response to endogenous and exogenous stressors
SO MITOCHONDRION
LA English
DT Meeting Abstract
C1 [Frye, Richard E.; Frye, Richard E.; Rose, Shannon; James, S. Jill] Univ Arkansas Med Sci, Arkansas Childrens Hosp, Res Inst, Little Rock, AR 72202 USA.
NR 0
TC 0
Z9 0
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1567-7249
J9 MITOCHONDRION
JI Mitochondrion
PD SEP
PY 2012
VL 12
IS 5
MA 23
BP 558
EP 558
DI 10.1016/j.mito.2012.07.022
PG 1
WC Cell Biology; Genetics & Heredity
SC Cell Biology; Genetics & Heredity
GA 009KC
UT WOS:000309023700030
ER
PT J
AU Rose, S
Rose, S
Melnyk, S
Frye, RE
James, SJ
AF Rose, Shannon
Rose, Shannon
Melnyk, Stepan
Frye, Richard E.
James, S. Jill
TI Increased susceptibility to reactive oxygen species in autism
lymphoblastoid cells is mediated by mitochondrial dysfunction
SO MITOCHONDRION
LA English
DT Meeting Abstract
C1 [Rose, Shannon; Rose, Shannon; Melnyk, Stepan; Frye, Richard E.; James, S. Jill] Univ Arkansas Med Sci, Arkansas Childrens Hosp, Res Inst, Little Rock, AR 72202 USA.
NR 0
TC 0
Z9 0
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1567-7249
J9 MITOCHONDRION
JI Mitochondrion
PD SEP
PY 2012
VL 12
IS 5
MA 35
BP 562
EP 562
DI 10.1016/j.mito.2012.07.033
PG 1
WC Cell Biology; Genetics & Heredity
SC Cell Biology; Genetics & Heredity
GA 009KC
UT WOS:000309023700041
ER
PT J
AU Parker, ME
Moran, MF
Foley, JT
Weiss, MJ
AF Parker, Mary Elizabeth
Moran, Matthew F.
Foley, John T.
Weiss, Michael J.
TI Mitochondrial disorders and autism: A new avenue of research on movement
SO MITOCHONDRION
LA English
DT Meeting Abstract
C1 [Parker, Mary Elizabeth] Texas State Univ, San Marcos, TX USA.
[Moran, Matthew F.] Sacred Heart Univ, Fairfield, CT USA.
[Foley, John T.] SUNY Coll Cortland, Cortland, NY 13045 USA.
[Weiss, Michael J.] Fairfield Univ, Fairfield, CT 06430 USA.
NR 0
TC 0
Z9 0
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1567-7249
EI 1872-8278
J9 MITOCHONDRION
JI Mitochondrion
PD SEP
PY 2012
VL 12
IS 5
MA 50
BP 568
EP 569
DI 10.1016/j.mito.2012.07.048
PG 2
WC Cell Biology; Genetics & Heredity
SC Cell Biology; Genetics & Heredity
GA 009KC
UT WOS:000309023700056
ER
PT J
AU Johnson, MH
AF Johnson, Mark H.
TI Executive function and developmental disorders: the flip side of the
coin
SO TRENDS IN COGNITIVE SCIENCES
LA English
DT Review
ID ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; DEFICIT HYPERACTIVITY
DISORDER; AUTISM SPECTRUM DISORDERS; PREFRONTAL CORTEX; CHILDREN; ADHD;
HETEROGENEITY; CHILDHOOD; INFANTS; MEMORY
AB Several common developmental disorders emerge during early to middle childhood (e.g. autism, attention deficit and hyperactivity disorder) and are associated with impairments in executive function (EF). Contrary to the prevailing view, I suggest that, within populations at-risk, the association with EF is found because individuals with strong EF skills are better able to compensate for atypicalities in other brain systems early in life, and are therefore less likely to receive a diagnosis later in life. I discuss evidence consistent with this view from considerations of individual variability, neuroimaging, and genetics. To the extent that this view is correct, it offers hope for remediation of some later emerging symptoms, as evidence from typical groups indicates that training programs for EF in preschoolers may be effective in improving skills.
C1 Univ London Birkbeck Coll, Dept Psychol, Ctr Brain & Cognit Dev, London WC1E 7HX, England.
RP Johnson, MH (reprint author), Univ London Birkbeck Coll, Dept Psychol, Ctr Brain & Cognit Dev, Henry Wellcome Bldg,Malet St, London WC1E 7HX, England.
EM mark.johnson@bbk.ac.uk
FU UK Medical Research Council (MRC) [G0701484]
FX I acknowledge support from the UK Medical Research Council (MRC
G0701484).
CR Alvarez JA, 2006, NEUROPSYCHOL REV, V16, P17, DOI 10.1007/s11065-006-9002-x
Barnes JJM, 2011, BIOL PSYCHIAT, V69, pE127, DOI 10.1016/j.biopsych.2010.12.040
Bechara A, 2000, BRAIN, V123, P2189, DOI 10.1093/brain/123.11.2189
Cahalane DJ, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0016113
Castellanos FX, 2012, TRENDS COGN SCI, V16, P17, DOI 10.1016/j.tics.2011.11.007
Dehaene-Lambertz G, 2002, SCIENCE, V298, P2013, DOI 10.1126/science.1077066
Diamond A, 2011, SCIENCE, V333, P959, DOI 10.1126/science.1204529
Doria V, 2010, P NATL ACAD SCI USA, V107, P20015, DOI 10.1073/pnas.1007921107
Elsabbagh M, 2010, TRENDS COGN SCI, V14, P81, DOI 10.1016/j.tics.2009.12.005
Fair DA, 2012, P NATL ACAD SCI USA, V109, P6769, DOI 10.1073/pnas.1115365109
Fassbender C, 2006, CLIN PSYCHOL REV, V26, P445, DOI 10.1016/j.cpr.2006.01.003
Franke B, 2010, NEUROPSYCHOPHARMACOL, V35, P656, DOI 10.1038/npp.2009.170
Gadow KD, 2008, J CHILD PSYCHOL PSYC, V49, P1331, DOI 10.1111/j.1469-7610.2008.01952.x
Geschwind DH, 2011, TRENDS COGN SCI, V15, P409, DOI 10.1016/j.tics.2011.07.003
Geurts HM, 2004, J CHILD PSYCHOL PSYC, V45, P836, DOI 10.1111/j.1469-7610.2004.00276.x
Gogtay N, 2004, P NATL ACAD SCI USA, V101, P8174, DOI 10.1073/pnas.0402680101
Halperin JM, 2006, PSYCHOL BULL, V132, P560, DOI 10.1037/0033-2909.132.4.560
Happe F, 1999, TRENDS COGN SCI, V3, P216, DOI 10.1016/S1364-6613(99)01318-2
Hill EL, 2004, TRENDS COGN SCI, V8, P26, DOI 10.1016/j.tics.2003.11.003
Johnson MH, 2011, DEVELOPMENTAL SCIENCE: AN ADVANCED TEXTBOOK, SIXTH EDITION, P201
Kaiser MD, 2010, P NATL ACAD SCI USA, V107, P21223, DOI 10.1073/pnas.1010412107
Klingberg T, 2010, TRENDS COGN SCI, V14, P317, DOI 10.1016/j.tics.2010.05.002
Losh M, 2009, ARCH GEN PSYCHIAT, V66, P518, DOI 10.1001/archgenpsychiatry.2009.34
Nigg JT, 2005, BIOL PSYCHIAT, V57, P1424, DOI 10.1016/j.biopsych.2004.11.011
Nigg JT, 2005, BIOL PSYCHIAT, V57, P1224, DOI 10.1016/j.biopsych.2004.08.025
Olley A, 2007, J AFFECT DISORDERS, V104, P15, DOI 10.1016/j.jad.2007.02.023
Pennington BF, 1996, J CHILD PSYCHOL PSYC, V37, P51, DOI 10.1111/j.1469-7610.1996.tb01380.x
Plessen KJ, 2009, J PSYCHOSOM RES, V67, P559, DOI 10.1016/j.jpsychores.2009.07.005
Rommelse NNJ, 2010, EUR CHILD ADOLES PSY, V19, P281, DOI 10.1007/s00787-010-0092-x
Russell J., 1997, AUTISM EXECUTIVE DIS, P256
Shaw P, 2008, J NEUROSCI, V28, P3586, DOI 10.1523/JNEUROSCI.5309-07.2008
Sonuga-Barke EJS, 2011, EXPERT REV NEUROTHER, V11, P557, DOI [10.1586/ern.11.39, 10.1586/ERN.11.39]
THATCHER RW, 1992, BRAIN COGNITION, V20, P24, DOI 10.1016/0278-2626(92)90060-Y
Tzourio-Mazoyer N, 2002, NEUROIMAGE, V15, P454, DOI 10.1006/nimg.2001.0979
Velligan D I, 1999, Semin Clin Neuropsychiatry, V4, P24
Wass S., DEV REV IN PRESS
Wass S, 2011, CURR BIOL, V21, P1543, DOI 10.1016/j.cub.2011.08.004
White S., 2012, J AUTISM DEV DISORD
Yerys BE, 2009, AUTISM RES, V2, P322, DOI 10.1002/aur.103
NR 39
TC 26
Z9 28
PU ELSEVIER SCIENCE LONDON
PI LONDON
PA 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND
SN 1364-6613
J9 TRENDS COGN SCI
JI TRENDS COGN. SCI.
PD SEP
PY 2012
VL 16
IS 9
BP 454
EP 457
DI 10.1016/j.tics.2012.07.001
PG 4
WC Behavioral Sciences; Neurosciences; Psychology, Experimental
SC Behavioral Sciences; Neurosciences & Neurology; Psychology
GA 007QD
UT WOS:000308902300005
PM 22835639
ER
PT J
AU Reno, J
AF Reno, Joshua
TI Technically Speaking: On Equipping and Evaluating "Unnatural" Language
Learners
SO AMERICAN ANTHROPOLOGIST
LA English
DT Article
DE language development; semiotics; materiality; posthumanism; linguistic
ideology
ID AUTISM; COMMUNICATION; ANTHROPOLOGY; CHILDREN; DISABILITY; SPEECH;
VOICE; HAND
AB This article compares different communicative trials for apes in captivity and children with autism in order to investigate how ideological assumptions about linguistic agency and impairment are constructed and challenged in practice. To the extent that Euro-American techniques of "unnatural" language instruction developed during the Cold War era have been successful, it is because communicative interactions are broken down into basic components, and would-be language learners are equipped with materials, devices, and habits that make up for their distinct bio/social deficits. Such linguistic equipment can present a challenge to the ideological presumption of a subject inherently gifted with the rudiments of talk, that is, the human as naturally speaking. However, this ideology can reassert itself if the active contribution of unnatural language learners to their technoscientific trials is downplayed. In order to counter this tendency, I propose that speech acts be reimagined as part of a more encompassing semiotic ensemble.
C1 SUNY Binghamton, Dept Anthropol, Binghamton, NY 13902 USA.
RP Reno, J (reprint author), SUNY Binghamton, Dept Anthropol, Binghamton, NY 13902 USA.
EM jreno@binghamton.edu
CR Adams Carol J., 1995, NEITHER MAN NOR BEAS
Agha Asif, 2005, J LINGUIST ANTHROPOL, V15, P38, DOI [10.1525/jlin.2005.15.1.38, DOI 10.1525/JLIN.2005.15.1.38]
Albrecht G. J., 2001, HDB DISABILITY STUDI
Anderson B., 1991, IMAGINED COMMUNITIES
Axel BK, 2006, CULT ANTHROPOL, V21, P354, DOI 10.1525/can.2006.21.3.354
Bauman R., 2003, VOICES MODERNITY LAN
Benham Kelley, 2005, BAD GORILLA KOKO BAD
Blackmore S, 2000, MEME MACHINE
Boellstorff T, 2008, COMING OF AGE IN SECOND LIFE: AN ANTHROPOLOGIST EXPLORES THE VIRTUALLY HUMAN, P1
Boyer D, 2010, ANTHROPOL QUART, V83, P73
Bumiller K, 2008, SIGNS, V33, P967, DOI 10.1086/528848
Callon M., 1981, ADV SOCIAL THEORY ME, P277
Carr D, 2007, J AUTISM DEV DISORD, V37, P780, DOI 10.1007/s10803-006-0204-0
Cody F, 2010, AM ANTHROPOL, V112, P200, DOI 10.1111/j.1548-1433.2010.01219.x
Connor Steven, 2000, DUMBSTRUCK CULTURAL
Corballis MC, 2003, BEHAV BRAIN SCI, V26, P199, DOI 10.1017/S0140525X03000062
Cowley S. J., 2003, ALTERNATION, V10, P229
Cowley SJ, 2007, INTERACT STUD, V8, P83, DOI 10.1075/is.8.1.06cow
Cowley SJ, 2006, ROUTL ADV COMMUN LIN, V4, P200
Cowley Stephen J., 2005, INT J COMPUTATIONAL, V3, P44
Dautenhahn K, 2004, PRAGMAT COGN, V12, P1, DOI DOI 10.1075/PC.12.1.03DAU
Davis Leonard, 2005, ENFORCING NORMALCY D
Deacon T., 1997, SYMBOLIC SPECIES
Derrida Jacques, 2003, ZOONTOLOGIES QUESTIO, P121
Duranti A, 2009, J LINGUIST ANTHROPOL, V19, P205, DOI 10.1111/j.1548-1395.2009.01031.x
Duranti Alessandro, 2005, COMPANION LINGUISTIC, P451, DOI 10.1111/b.9781405144308.2005.00023.x
Everett Daniel L., 2012, LANGUAGE CULTURAL TO
Gellner Ernest, 1974, LEGITIMATION BELIEF
Gernsbacher Morton Ann, 2007, ASS PSYCHOL SCI, V20, P31
Goffman Erving, 1981, FORMS TALK
Goldin-Meadow S., 2003, RESILIENCE LANGUAGE
GOODWIN C., 2000, LANGUAGE GESTURE, P84, DOI 10.1017/CBO9780511620850.006
Goodwin C., 2004, J LINGUIST ANTHROPOL, V14, P151, DOI 10.1525/jlin.2004.14.2.151
Goodwin Charles, 2011, EMBODIED INTERACTION
Groce NE, 2000, AM ANTHROPOL, V102, P818, DOI 10.1525/aa.2000.102.4.818
Hacking I, 2009, DAEDALUS-US, V138, P44, DOI 10.1162/daed.2009.138.3.44
Haraway D., 1989, PRIMATE VISIONS GEND
HAVILAND JB, 1998, J LINGUIST ANTHROPOL, V8, P162, DOI 10.1525/jlin.1998.8.2.162
Hayles N. Katherine, 1999, WE BECAME POSTHUMAN
Hediger Heini, 2010, ESSENTIAL READINGS B, P237
Hoffmann-Dilloway E, 2011, LANG SOC, V40, P285, DOI 10.1017/S0047404511000194
Howlin P, 2007, J CHILD PSYCHOL PSYC, V48, P473, DOI 10.1111/j.1469-7610.2006.01707.x
Ingold T., 2000, PERCEPTION ENV
Irvine J. T., 1996, NATURAL HIST DISCOUR, P131
Jacobson JW, 2005, CONTROVERSIAL THERAPIES FOR DEVELOPMENTAL DISABILITES: FAD, FASHION, AND SCIENCE IN PROFESSIONAL PRACTICE, P363
Keane W, 2003, LANG COMMUN, V23, P409, DOI 10.1016/S0271-5309(03)00010-7
Keane W., 2000, J LINGUIST ANTHROPOL, V9, P271
Keane W, 2011, J LINGUIST ANTHROPOL, V21, P166, DOI 10.1111/j.1548-1395.2011.01104.x
Keane W, 2007, ANTHROPOL CHRISTIAN, V1, P1
Keating E, 2003, LANG SOC, V32, P693, DOI 10.1017/S0047404503325047
Latour B., 2004, POLITICS NATURE BRIN
Latour B., 1987, SCI ACTION
Latour B, 2005, REASSEMBLING SOCIAL
Leroi-Gourhan A., 1993, GESTURE AND SPEECH
Levinson Stephen C, 2006, ROOTS HUMAN SOCIALIT, P39
Lynch Michael, 1990, REPRESENTATION SCI P
McNeiil David, 1996, HAND MIND WHAT GESTU
McNeill D, 2008, INTERACT STUD, V9, P117, DOI 10.1075/is.9.1.09mcn
Mills M., 2010, SOCIAL TEXT, V28, P35
Mitchell David T., 1997, BODY PHYS DIFFERENCE
Moser I., 2001, MAKING VOICES NEW ME
Nadesan Majia Holmer, 2005, CONSTRUCTING AUTISM
Ochs E, 2004, DISCOURSE STUD, V6, P147, DOI 10.1177/1461445604041766
Ochs E, 2010, ETHOS, V38, P69, DOI 10.1111/j.1548-1352.2009.01082.x
Ochs E, 2005, DISCOURSE STUD, V7, P547, DOI 10.1177/1461445605054406
PEPPERELL R, 1995, POSTHUMAN CONDITION
Price David H., 2008, ANTHR INTELLIGENCE D
SAVAGERUMBAUGH ES, 1980, SCIENCE, V210, P922, DOI 10.1126/science.7434008
Schieffelin Bambi, 1996, HDB CHILD LANGUAGE, P73
Seidenberg M.S., 1981, Annals of the New York Academy of Sciences, V364, P115
SEIDENBERG MS, 1987, J EXP PSYCHOL GEN, V116, P279, DOI 10.1037/0096-3445.116.3.279
Senghas RJ, 2002, ANNU REV ANTHROPOL, V31, P69, DOI 10.1146/annurev.anthro.31.020402.101302
Sicoli MA, 2010, LANG SOC, V39, P521, DOI 10.1017/S0047404510000436
Silverstein M, 2003, LANG COMMUN, V23, P193, DOI 10.1016/S0271-5309(03)00013-2
Silverstein Michael, 1996, NATURAL HIST DISCOUR
Solomon O, 2010, ETHOS, V38, P143, DOI 10.1111/j.1548-1352.2009.01085.x
Solomon Olga, 2004, COMPANION PSYCHOL AN, P140
Strathern Marilyn, 1988, GENDER GIFT
Strathern Marilyn, 2011, WORKSH ENT LIV MESS
Thomas M., 2005, LANGUAGE LEARNING DE, V1, P65, DOI DOI 10.1207/S15473341LLD0101_5
Uddin Lisa, 2006, PARALLAX, V12, P110, DOI 10.1080/13534640500448783
Warner Michael, 1990, LETT REPUBLIC PUBLIC
Wilf E, 2011, CULT ANTHROPOL, V26, P462, DOI 10.1111/j.1548-1360.2011.01107.x
NR 83
TC 1
Z9 1
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0002-7294
J9 AM ANTHROPOL
JI Am. Anthropol.
PD SEP
PY 2012
VL 114
IS 3
BP 406
EP 419
DI 10.1111/j.1548-1433.2012.01442.x
PG 14
WC Anthropology
SC Anthropology
GA 999LV
UT WOS:000308314900003
ER
PT J
AU Losh, M
Klusek, J
Martin, GE
Sideris, J
Parlier, M
Piven, J
AF Losh, Molly
Klusek, Jessica
Martin, Gary E.
Sideris, John
Parlier, Morgan
Piven, Joseph
TI Defining Genetically Meaningful Language and Personality Traits in
Relatives of Individuals With Fragile X Syndrome and Relatives of
Individuals With Autism
SO AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
LA English
DT Article
DE autism; fragile X syndrome; fragile X premutation; FMR1; language; broad
autism phenotype
ID FMR1 MESSENGER-RNA; MENTAL-RETARDATION; PREMUTATION CARRIERS; AMYGDALA
DYSFUNCTION; PROTEIN EXPRESSION; MULTIPLE-INCIDENCE; IDIOPATHIC AUTISM;
SPECTRUM DISORDER; GABA(A) RECEPTOR; YOUNG-CHILDREN
AB Substantial phenotypic overlap exists between fragile X syndrome (FXS) and autism, suggesting that FMR1 (the gene causing FXS) poses a significant risk for autism. Cross-population comparisons of FXS and autism therefore offer a potentially valuable method for refining the range of phenotypes associated with variation in FMR1. This study adopted a broader phenotype approach, focusing on parents who are at increased genetic liability for autism or FXS. Women who were carriers of FMR1 in its premutation state were compared with mothers of individuals with autism, and controls in an attempt to determine whether subtle features of the broad autism phenotype may express at elevated rates among FMR1 premutation carriers. The principal personality and language features comprising the broad autism phenotype (i.e., rigid and aloof personality, and particular patterns of pragmatic language use) were assessed among 49 premutation carriers who were mothers of individuals with FXS, 89 mothers of individuals with autism, and 23 mothers of typically developing individuals. Relative to controls, the autism and premutation parent groups showed elevated rates of certain personality and language characteristics of the broad autism phenotype. Findings suggest partially overlapping personality and language profiles among autism and premutation parent groups, with rigid personality style and patterns of pragmatic language use emerging as features most clearly shared between groups. These results provide further evidence for the overlap of autism and FXS, and may implicate FMR1 in some of the subtle features comprising the broad autism phenotype. (C) 2012 Wiley Periodicals, Inc.
C1 [Losh, Molly] Northwestern Univ, Roxelyn & Richard Pepper Dept Commun Sci & Disord, Evanston, IL 60208 USA.
[Klusek, Jessica; Martin, Gary E.] Univ N Carolina, Dept Allied Hlth Sci, Div Speech & Hearing Sci, Chapel Hill, NC 27515 USA.
[Klusek, Jessica; Martin, Gary E.; Sideris, John] Univ N Carolina, Frank Porter Graham Child Dev Inst, Chapel Hill, NC 27515 USA.
[Parlier, Morgan; Piven, Joseph] Univ N Carolina, Carolina Inst Dev Disabil, Chapel Hill, NC 27515 USA.
RP Losh, M (reprint author), Northwestern Univ, Roxelyn & Richard Pepper Dept Commun Sci & Disord, Frances Searle 2-340, Evanston, IL 60208 USA.
EM m-losh@northwestern.edu
FU National Institutes of Health [R03 MH079998-01, R01 DC010191-01A1, R01
HD038819, R01 HD038819-09S1, U54 MH66418]; National Science Foundation
[BCS-0820394]
FX Grant sponsor: National Institutes of Health (R03 MH079998-01, R01
DC010191-01A1, R01 HD038819 and R01 HD038819-09S1, and #U54 MH66418) and
National Science Foundation (BCS-0820394).
CR Adams PE, 2010, AM J MED GENET B, V153B, P775, DOI 10.1002/ajmg.b.31046
Allingham-Hawkins Diane J., 1999, American Journal of Medical Genetics, V83, P322, DOI 10.1002/(SICI)1096-8628(19990402)83:4<322::AID-AJMG17>3.0.CO;2-B
American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th
Aziz M, 2003, AM J MED GENET B, V121B, P119, DOI 10.1002/ajmg.b.20030
BAILEY A, 1993, J CHILD PSYCHOL PSYC, V34, P673, DOI 10.1111/j.1469-7610.1993.tb01064.x
Bailey DB, 2008, AM J MED GENET A, V146A, P2060, DOI 10.1002/ajmg.a.32439
BaronCohen S, 1997, J COGNITIVE NEUROSCI, V9, P548, DOI 10.1162/jocn.1997.9.4.548
Bear MF, 2004, TRENDS NEUROSCI, V27, P370, DOI 10.1016/j.tins.2004.04.009
Berry-Kravis E, 2007, AM J MED GENET A, V143A, P19, DOI 10.1002/ajmg.a.31559
BOLTON P, 1994, J CHILD PSYCHOL PSYC, V35, P877, DOI 10.1111/j.1469-7610.1994.tb02300.x
Bourgeois JA, 2009, J CLIN PSYCHIAT, V70, P852, DOI 10.4088/JCP.08m04476
Clifford S, 2007, J AUTISM DEV DISORD, V37, P738, DOI 10.1007/s10803-006-0205-z
Constantino JN, 2005, SOCIAL RESPONSIVENES
Cornish KM, 2009, BRAIN COGNITION, V69, P551, DOI 10.1016/j.bandc.2008.11.006
Darnell JC, 2011, CELL, V146, P247, DOI 10.1016/j.cell.2011.06.013
D'Hulst C, 2006, BRAIN RES, V1121, P238, DOI 10.1016/j.brainres.2006.08.115
D'Hulst C, 2007, TRENDS NEUROSCI, V30, P425, DOI 10.1016/j.tins.2007.06.003
Dombrowski C, 2002, HUM MOL GENET, V11, P371, DOI 10.1093/hmg/11.4.371
Dykens E. M., 1997, HDB AUTISM PERVASIVE, P388
Farzin F, 2006, J DEV BEHAV PEDIATR, V27, pS137, DOI 10.1097/00004703-200604002-00012
Fatemi SH, 2010, SCHIZOPHR RES, V124, P246, DOI 10.1016/j.schres.2010.07.017
Fatemi SH, 2010, NEUROPHARMACOLOGY, V60, P1221
Fombonne E, 1997, J CHILD PSYCHOL PSYC, V38, P667, DOI 10.1111/j.1469-7610.1997.tb01694.x
Franke P, 1998, PSYCHIAT RES, V80, P113, DOI 10.1016/S0165-1781(98)00055-9
Goodlin-Jones BL, 2004, J DEV BEHAV PEDIATR, V25, P392, DOI 10.1097/00004703-200412000-00002
Goodrich-Hunsaker NJ, 2011, BRAIN COGNITION, V75, P255, DOI 10.1016/j.bandc.2011.01.001
Hagerman R., 2010, MOL AUTISM, V1, P1, DOI DOI 10.1186/2040-2392-1-12
Hall SS, 2010, J AM ACAD CHILD PSY, V49, P921, DOI 10.1016/j.jaac.2010.07.001
Hall SS, 2008, AM J MENT RETARD, V113, P44, DOI 10.1352/0895-8017(2008)113[44:CSAABI]2.0.CO;2
Hashimoto R, 2011, J PSYCHIATR RES, V45, P36, DOI 10.1016/j.jpsychires.2010.04.030
Hashimoto RI, 2011, MOVEMENT DISORD, V26, P1329, DOI 10.1002/mds.23646
Hatton DD, 2006, AM J MED GENET A, V140A, P1804, DOI 10.1002/ajmg.a.31286
Hazlett HC, 2009, J NEURODEV DISORD, V1, P81, DOI 10.1007/s11689-009-9009-8
Hessl D, 2004, MENT RETARD DEV D R, V10, P17, DOI 10.1002/mrdd.20004
Hessl D, 2007, BRAIN, V130, P404, DOI 10.1093/brain/awl338
Hessl D, 2011, BIOL PSYCHIAT, V70, P859, DOI 10.1016/j.biopsych.2011.05.033
Hoeft F, 2011, ARCH GEN PSYCHIAT, V68, P295, DOI 10.1001/archgenpsychiatry.2010.153
Huber KM, 2002, P NATL ACAD SCI USA, V99, P7746, DOI 10.1073/pnas.122205699
Hunter JE, 2009, GENET MED, V11, P79, DOI 10.1097/GIM.0b013e31818de6ee
Hunter JE, 2010, CLIN GENET, V77, P374, DOI 10.1111/j.1399-0004.2009.01317.x
JORESKOG KG, 1994, PSYCHOMETRIKA, V59, P381, DOI 10.1007/BF02296131
Kaufmann WE, 2004, AM J MED GENET A, V129A, P225, DOI 10.1002/ajmg.a.30229
Keri S, 2010, BRAIN COGNITION, V72, P197, DOI 10.1016/j.bandc.2009.08.010
Kielinen M, 2004, AUTISM, V8, P49, DOI 10.1177/1362361304040638
Kogan CS, 2010, BRAIN COGNITION, V73, P236, DOI 10.1016/j.bandc.2010.05.008
Koldewyn K, 2008, BRAIN IMAGING BEHAV, V2, P105, DOI 10.1007/s11682-008-9020-9
KRAMER CY, 1956, BIOMETRICS, V12, P307, DOI 10.2307/3001469
Krueger DD, 2011, ANNU REV MED, V62, P411, DOI 10.1146/annurev-med-061109-134644
LANDA R, 1992, PSYCHOL MED, V22, P245
Loesch DZ, 2007, NEUROSCI BIOBEHAV R, V31, P315, DOI 10.1016/j.neubiorev.2006.09.007
Losh M, 2007, J CHILD PSYCHOL PSYC, V48, P105, DOI 10.1111/j.1469-7610.2006.01594.x
Losh M., 2011, AUTISM SPECTRUM DISO, P457
Losh M, 2008, AM J MED GENET B, V147B, P424, DOI 10.1002/ajmg.b.30612
Losh M, 2009, ARCH GEN PSYCHIAT, V66, P518, DOI 10.1001/archgenpsychiatry.2009.34
Moy SS, 2009, GENES BRAIN BEHAV, V8, P129, DOI 10.1111/j.1601-183X.2008.00452.x
Murphy M, 2000, PSYCHOL MED, V30, P1411, DOI 10.1017/S0033291799002949
Philofsky A, 2004, AM J MENT RETARD, V109, P208, DOI 10.1352/0895-8017(2004)109<208:LACFAA>2.0.CO;2
PIVEN J, 1994, PSYCHOL MED, V24, P783
Piven J, 1997, AM J MED GENET, V74, P398, DOI 10.1002/(SICI)1096-8628(19970725)74:4<398::AID-AJMG11>3.0.CO;2-D
Qin M, 2011, NEUROBIOL DIS, V42, P85, DOI 10.1016/j.nbd.2011.01.008
Roberts JE, 2009, AM J MED GENET B, V150B, P130, DOI 10.1002/ajmg.b.30786
Rogers SJ, 2001, J DEV BEHAV PEDIATR, V22, P409
ROUSSEAU F, 1995, AM J HUM GENET, V57, P1006
Selmeczy D, 2011, BRAIN IMAGING BEHAV, V5, P285, DOI 10.1007/s11682-011-9132-5
Tassone F, 2000, AM J HUM GENET, V66, P6, DOI 10.1086/302720
Tassone F, 2000, AM J MED GENET, V91, P144, DOI 10.1002/(SICI)1096-8628(20000313)91:2<144::AID-AJMG14>3.0.CO;2-V
Tyrer P., 1988, PERSONALITY DISORDER, P51
Wang LW, 2010, NEUROTHERAPEUTICS, V7, P264, DOI 10.1016/j.nurt.2010.05.005
Wilson LB, 2009, PSYCHIAT RES-NEUROIM, V174, P138, DOI 10.1016/j.pscychresns.2009.04.013
NR 69
TC 7
Z9 7
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1552-4841
J9 AM J MED GENET B
JI Am. J. Med. Genet. B
PD SEP
PY 2012
VL 159B
IS 6
BP 660
EP 668
DI 10.1002/ajmg.b.32070
PG 9
WC Genetics & Heredity; Psychiatry
SC Genetics & Heredity; Psychiatry
GA 001WW
UT WOS:000308492000005
PM 22693142
ER
PT J
AU Gau, SSF
Liao, HM
Hong, CC
Chien, WH
Chen, CH
AF Gau, Susan Shur-Fen
Liao, Hsiao-Mei
Hong, Chao-Chun
Chien, Wei-Hsien
Chen, Chia-Hsiang
TI Identification of Two Inherited Copy Number Variants in a Male with
Autism Supports Two-Hit and Compound Heterozygosity Models of Autism
SO AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
LA English
DT Article
DE autism; CNV; genetics; two-hit model; compound heterozygosity
ID TRANSFER-RNA SYNTHETASE; PROTEIN PHOSPHATASE 2A; SPECTRUM DISORDERS;
PSYCHOMETRIC PROPERTIES; CHINESE VERSION; HAN CHINESE; GENETIC
SUSCEPTIBILITY; TAIWAN; REPEAT; POU4F3
AB Autism is a childhood-onset neurodevelopmental disorder with complex genetic mechanism underlying its etiology. Recent studies revealed that a few single de novo copy number variants of genomic DNA (copy number variants [CNVs]) are pathogenic and causal in some sporadic cases, adding support to the hypothesis that some sporadic autism might be caused by single rare mutation with large clinical effect. In this study, we report the detection of two novel private CNVs simultaneously in a male patient with autism. These two CNVs include a micro-duplication of similar to 4.5 Mb at chromosome 4q12-13.1 that was transmitted from his mother and a microdeletion of similar to 1.8 Mb at 5q32 that was transmitted from his father. Several genes such as LPHN3, POU4F3, SH3RF2, and TCERG1 mapped to these two regions have psychiatric implications. However, the parents had only mild degree of attention deficit symptoms but did not demonstrate any obvious autistic symptoms or psychopathology. Our findings indicate that each of these two CNVs alone may not be pathogenic enough to cause clinical symptoms in their respective carriers, and hence they can be transmitted within each individual family. However, concomitant presence of these two CNVs might result in the clinical phenotypes of the affected patient reported here. Thus, our report of this family may represent an example to show that two hits of CNV and the presence of compound heterozygosity might be important mechanisms underlying the pathogenesis of autism. (C) 2012 Wiley Periodicals, Inc.
C1 [Gau, Susan Shur-Fen; Hong, Chao-Chun; Chen, Chia-Hsiang] Natl Taiwan Univ, Dept Psychiat, Coll Med, Taipei 10764, Taiwan.
[Gau, Susan Shur-Fen] Natl Taiwan Univ Hosp, Dept Psychiat, Taipei, Taiwan.
[Gau, Susan Shur-Fen] Natl Taiwan Univ, Dept Psychol, Grad Inst Brain & Mind Sci, Taipei 10764, Taiwan.
[Gau, Susan Shur-Fen] Natl Taiwan Univ, Grad Inst Epidemiol & Prevent Med, Taipei 10764, Taiwan.
[Liao, Hsiao-Mei] Natl Tsing Hua Univ, Inst Biotechnol, Hsinchu, Taiwan.
[Liao, Hsiao-Mei] Natl Tsing Hua Univ, Grad Program Biotechnol Med, Hsinchu, Taiwan.
[Chien, Wei-Hsien] Fu Jen Catholic Univ, Dept Occupat Therapy, Coll Med, New Taipei City, Taiwan.
[Chen, Chia-Hsiang] Natl Hlth Res Inst, Div Mental Hlth & Addict Med, Inst Populat Hlth Sci, Zhunan 350, Taiwan.
RP Gau, SSF (reprint author), Natl Taiwan Univ Hosp & Coll Med, Dept Psychiat, 7 Chung Shan S Rd, Taipei 10002, Taiwan.
EM gaushufe@ntu.edu.tw; cchen@nhri.org.tw
RI Chen, Chia-Hsiang /E-3939-2010
FU National Science Council [NSC96-3112-B-002-033, NSC97-3112-B-002-009,
NSC98-3112-B-002-004, NSC99-3112-B-002-036]; National Taiwan University
[10R81918-03]; National Health Research Institutes, Taiwan
FX Grant sponsor: National Science Council; Grant numbers:
NSC96-3112-B-002-033, NSC97-3112-B-002-009, NSC98-3112-B-002-004,
NSC99-3112-B-002-036; Grant sponsor: National Taiwan University; Grant
number: 10R81918-03; Grant sponsor: National Health Research Institutes,
Taiwan.
CR Arango M, 2006, J NEUROSCI, V26, P4649, DOI 10.1523/JNEUROSCI.5409-05.2006
Arcos-Burgos M, 2010, MOL PSYCHIATR, V15, P1053, DOI 10.1038/mp.2010.6
Chen CM, 2009, AM J MED GENET B, V150B, P124, DOI 10.1002/ajmg.b.30785
Chen X, 2011, NUCLEIC ACIDS RES, V39, P235, DOI 10.1093/nar/gkq763
Chien YL, 2011, COMPR PSYCHIAT, V52, P195, DOI 10.1016/j.comppsych.2010.03.009
Chien YL, 2011, PROG NEURO-PSYCHOPH, V35, P1512, DOI 10.1016/j.pnpbp.2011.04.010
Collin RWJ, 2008, HUM MUTAT, V29, P545, DOI 10.1002/humu.20693
de Heer AMR, 2009, ANN OTO RHINOL LARYN, V118, P313
Eapen V, 2011, CURR OPIN PSYCHIATR, V24, P226, DOI 10.1097/YCO.0b013e328345927e
Franke B, 2012, MOL PSYCHIATR, V17, P960, DOI 10.1038/mp.2011.138
Gao MY, 2009, J MOL HISTOL, V40, P227, DOI 10.1007/s10735-009-9234-1
Gau SSF, 2005, AM J PSYCHIAT, V162, P1344, DOI 10.1176/appi.ajp.162.7.1344
Gau SSF, 2010, PSYCHIAT CLIN NEUROS, V64, P70, DOI 10.1111/j.1440-1819.2009.02034.x
Gau SSF, 2008, INT J METH PSYCH RES, V17, P35, DOI 10.1002/mpr.237
Gau SSF, 2011, RES AUTISM SPECT DIS, V5, P809, DOI 10.1016/j.rasd.2010.09.010
Girirajan S, 2010, NAT GENET, V42, P203, DOI 10.1038/ng.534
Girirajan S, 2010, HUM MOL GENET, V19, pR176, DOI 10.1093/hmg/ddq366
Holbert S, 2001, P NATL ACAD SCI USA, V98, P1811, DOI 10.1073/pnas.041566798
Holmes SE, 1999, NAT GENET, V23, P391
Holt R, 2011, EMBO MOL MED, V3, P438, DOI 10.1002/emmm.201100157
Jain M, 2012, MOL PSYCHIATR, V17, P741, DOI 10.1038/mp.2011.59
Janssens V, 2001, BIOCHEM J, V353, P417, DOI 10.1042/0264-6021:3530417
Kim YS, 2011, AM J PSYCHIAT, V168, P904, DOI 10.1176/appi.ajp.2011.10101532
Kimura R, 2011, NEUROSCI LETT, V487, P354, DOI 10.1016/j.neulet.2010.10.055
Kogan MD, 2009, PEDIATRICS, V124, P1395, DOI 10.1542/peds.2009-1522
Lechward K, 2001, ACTA BIOCHIM POL, V48, P921
Lee HK, 2010, BIOCHEM BIOPH RES CO, V396, P626, DOI 10.1016/j.bbrc.2010.04.132
Lin CH, 2008, BMC GENET, V9, DOI 10.1186/1471-2156-9-92
Lin CH, 2009, GENOMICS, V94, P241, DOI 10.1016/j.ygeno.2009.06.004
Lin CH, 2010, HUM GENET, V128, P205, DOI 10.1007/s00439-010-0843-2
Marshall CR, 2008, AM J HUM GENET, V82, P477, DOI 10.1016/j.ajhg.2007.12.009
Martinez AF, 2011, AM J MED GENET B, V156B, P1, DOI 10.1002/ajmg.b.31137
Mitchell KJ, 2011, CURR OPIN NEUROBIOL, V21, P197, DOI 10.1016/j.conb.2010.08.009
O'Hearn Elizabeth, 2012, Handb Clin Neurol, V103, P535, DOI 10.1016/B978-0-444-51892-7.00034-6
Park SG, 2010, IUBMB LIFE, V62, P296, DOI 10.1002/iub.324
Pearson JL, 2008, J BIOL CHEM, V283, P7949, DOI 10.1074/jbc.M709402200
Pinto D, 2010, NATURE, V466, P368, DOI 10.1038/nature09146
Poot M, 2011, CYTOGENET GENOME RES, V135, P228, DOI 10.1159/000334064
Ribases M, 2011, GENES BRAIN BEHAV, V10, P149, DOI 10.1111/j.1601-183X.2010.00649.x
Schaaf CP, 2011, HUM MOL GENET, V20, P3366, DOI 10.1093/hmg/ddr243
Sebat J, 2007, SCIENCE, V316, P445, DOI 10.1126/science.1138659
State MW, 2011, NAT NEUROSCI, V14, P1499, DOI 10.1038/nn.2924
Vahava O, 1998, SCIENCE, V279, P1950, DOI 10.1126/science.279.5358.1950
Van Hoof C, 2003, BBA-MOL CELL RES, V1640, P97, DOI 10.1016/S0167-4889(03)00029-6
Veltman JA, 2010, NAT GENET, V42, P192, DOI 10.1038/ng0310-192
Wilhelm M, 2012, J BIOL CHEM, V287, P2247, DOI 10.1074/jbc.M111.269431
Yeh CB, 2008, INT J METH PSYCH RES, V17, P45, DOI 10.1002/mpr.241
NR 47
TC 6
Z9 6
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1552-4841
J9 AM J MED GENET B
JI Am. J. Med. Genet. B
PD SEP
PY 2012
VL 159B
IS 6
BP 710
EP 717
DI 10.1002/ajmg.b.32074
PG 8
WC Genetics & Heredity; Psychiatry
SC Genetics & Heredity; Psychiatry
GA 001WW
UT WOS:000308492000009
PM 22778016
ER
PT J
AU Schaaf, RC
Blanche, EI
AF Schaaf, Roseann C.
Blanche, Erna Imperatore
TI Emerging as Leaders in Autism Research and Practice: Using the
Data-Driven Intervention Process
SO AMERICAN JOURNAL OF OCCUPATIONAL THERAPY
LA English
DT Editorial Material
C1 [Schaaf, Roseann C.] Thomas Jefferson Univ, Jefferson Sch Hlth Profess, Farber Inst Neurosci, Dept Occupat Therapy, Philadelphia, PA 19107 USA.
[Blanche, Erna Imperatore] Univ So Calif, Div Occupat Sci & Occupat Therapy, Los Angeles, CA USA.
RP Schaaf, RC (reprint author), Thomas Jefferson Univ, Jefferson Sch Hlth Profess, Farber Inst Neurosci, Dept Occupat Therapy, 130 S 9th St,Edison 810, Philadelphia, PA 19107 USA.
EM roseann.schaaf@jefferson.edu
CR Ayres A. J., 1972, SENSORY INTEGRATION
Blanche E., 2006, SENSORY INTEGRATION, P91
Blanche E. I., 2001, CLIN OBSERVATION SEN
Burke Janice Posatery, 2012, Am J Occup Ther, V66, pe85, DOI 10.5014/ajot.2012.004432
Centers for Disease Control and Prevention, 2010, MAN CHILDR HAV AUT
Goin-Kochel R. P., 2007, RES AUTISM SPECT DIS, V3, P528
Green VA, 2006, RES DEV DISABIL, V27, P70, DOI 10.1016/j.ridd.2004.12.002
Jarbrink K, 2001, AUTISM, V5, P7, DOI 10.1177/1362361301005001002
Kanner L, 1943, NERV CHILD, V2, P217
Mandell D. S., 2005, INT M AUT RES BOST
McEwen I., 2009, WRITING CASE REPORTS
Miller-Kuhaneck H., 2010, AUTISM COMPREHENSIVE
Schaaf R, 2011, J AUTISM DEV DISORD, V41, P1436, DOI 10.1007/s10803-011-1303-0
Schaaf R. C., 2011, AM OCC THER ASS AUT
Sugai G, 2000, EXCEPTIONALITY, V8, P149
NR 15
TC 5
Z9 5
PU AMER OCCUPATIONAL THERAPY ASSOC, INC
PI BETHESDA
PA 4720 MONTGOMERY LANE, BETHESDA, MD 20814-3425 USA
SN 0272-9490
J9 AM J OCCUP THER
JI Am. J. Occup. Ther.
PD SEP-OCT
PY 2012
VL 66
IS 5
SI SI
BP 503
EP 505
PG 3
WC Rehabilitation
SC Rehabilitation
GA 006RJ
UT WOS:000308836200001
PM 22917115
ER
PT J
AU Kinnealey, M
Pfeiffer, B
Miller, J
Roan, C
Shoener, R
Ellner, ML
AF Kinnealey, Moya
Pfeiffer, Beth
Miller, Jennifer
Roan, Cecilia
Shoener, Rachel
Ellner, Matt L.
TI Effect of Classroom Modification on Attention and Engagement of Students
With Autism or Dyspraxia
SO AMERICAN JOURNAL OF OCCUPATIONAL THERAPY
LA English
DT Article
DE apraxias; attention; autistic disorder; environment; learning; sensation
ID SPECTRUM DISORDER; YOUNG-CHILDREN; ABNORMALITIES; PERFORMANCE; TASK
AB Students with autism display sensory sensitivities to environmental stimuli that affect their attending and engagement in classroom learning activities. The purpose of the study was to determine whether attending of 4 male students, ages 13-20, increased after the installation of sound-absorbing walls and halogen lighting. The multiple single-subject, mixed-method design, AB(B+C), included a 2-wk baseline and two intervention phases: 2 wk after sound-absorbing wall installation using the Owens Corning Basement Finishing System (TM) (Owens Corning, Toledo, OH) and 2 wk after halogen light installation. We calculated nonattending frequencies from videotaped class sessions and used visual analysis to measure within-phase and between-phase characteristics. Results included increased frequency and stability of attending and engagement and improved classroom performance, comfort, and mood. Journaling provided students' perspective on the modifications and reflected overall increased sensory comfort and themes of improved classroom environment, positive emotional response (mood), and improved classroom performance.
C1 [Kinnealey, Moya; Pfeiffer, Beth] Temple Univ, Dept Rehabil Sci, Occupat Therapy Program, Philadelphia, PA 19119 USA.
[Roan, Cecilia] Gloucester Cty Sch Dist, Sewell, NJ USA.
[Shoener, Rachel] TALK Inc, Newtown Sq, PA USA.
RP Kinnealey, M (reprint author), Temple Univ, Dept Rehabil Sci, Occupat Therapy Program, 648 W Phil Ellena St, Philadelphia, PA 19119 USA.
EM moya.kinnealey@temple.edu
CR Adams J. B., 2008, ADVICE PARENTS YOUNG
Altevogt BM, 2008, PEDIATRICS, V121, P1225, DOI 10.1542/peds.2007-3000
Ashburner J, 2008, AM J OCCUP THER, V62, P564
Baker AEZ, 2008, J AUTISM DEV DISORD, V38, P867, DOI 10.1007/s10803-007-0459-0
Barnhill G., 2000, FOCUS AUTISM OTHER D, V15, P146, DOI [10.1177/108835760001500303, DOI 10.1177/108835760001500303]
CAST, 2011, UN DES LEARN GUID VE
Chasin M., 2007, STAT DECIBEL LOUDNES
Corning Owens, 2007, OW CORN BAS FIN SYST
Coster W., 1998, SCH FUNCTION ASSESSM
Dunn W, 1999, SENSORY PROFILE USER
Fertel-Daly D, 2001, AM J OCCUP THER, V55, P629
Godek J., 2008, SCH ADM, V65, P32
Grandin T., 2011, MY EXPERIENCES VISUA
Grandin T., 1995, THINKING PICTURES OT
Gravel JS, 2006, EAR HEARING, V27, P299, DOI 10.1097/01.aud.0000215979.65645.22
Greenspan S. I., 2006, EARLY CHILDHOOD TODA, V21, P21
Greenspan SI, 1997, ZERO 3, V17, P5
Jimenez T. C., 2007, ISSUES TEACHER ED, V16, P41
Kuller R, 1998, ERGONOMICS, V41, P433, DOI 10.1080/001401398186928
Liss M, 2006, AUTISM, V10, P155, DOI 10.1177/1362361306062021
Lorelei I., 2003, NEXUS MAGAZINE, V10, P1
Martel L., 2003, LIGHT ELEMENT ERGONO
McCreery J., 2005, SCH PLANNING MANAGEM, V44, P1
Miller LJ, 2007, AM J OCCUP THER, V61, P228
Miller LJ, 2007, AM J OCCUP THER, V61, P135
Minshew NJ, 2008, J AUTISM DEV DISORD, V38, P1485, DOI 10.1007/s10803-007-0528-4
Mundy P, 2001, INT REV RES MENT RET, V23, P139
Northeast Energy Efficiency Partnerships, 2002, CLASSR LIGHT KNOW
ONeill M, 1997, J AUTISM DEV DISORD, V27, P283, DOI 10.1023/A:1025850431170
Ornitz E., 1988, BRAIN DYSFUNCT, V1, P309
Patten E, 2011, AM J SPEECH-LANG PAT, V20, P60, DOI 10.1044/1058-0360(2010/09-0081)
Pfeiffer B, 2008, AM J OCCUP THER, V62, P274
Portney LG., 2000, FDN CLIN RES APPL PR
Rice C., 2009, MORBIDITY AND MORTAL, V58, P1
Ruble LA, 2007, J AUTISM DEV DISORD, V37, P1457, DOI 10.1007/s10803-006-0222-y
Schilling DL, 2004, J AUTISM DEV DISORD, V34, P423, DOI 10.1023/B:JADD.0000037418.48587.f4
Tomchek SD, 2007, AM J OCCUP THER, V61, P190
VanBergeijk E, 2008, J AUTISM DEV DISORD, V38, P1359, DOI 10.1007/s10803-007-0524-8
NR 38
TC 6
Z9 6
PU AMER OCCUPATIONAL THERAPY ASSOC, INC
PI BETHESDA
PA 4720 MONTGOMERY LANE, BETHESDA, MD 20814-3425 USA
SN 0272-9490
J9 AM J OCCUP THER
JI Am. J. Occup. Ther.
PD SEP-OCT
PY 2012
VL 66
IS 5
SI SI
BP 511
EP 519
DI 10.5014/ajot.2012.004010
PG 9
WC Rehabilitation
SC Rehabilitation
GA 006RJ
UT WOS:000308836200003
PM 22917117
ER
PT J
AU Dunn, W
Cox, J
Foster, L
Mische-Lawson, L
Tanquary, J
AF Dunn, Winnie
Cox, Jane
Foster, Lauren
Mische-Lawson, Lisa
Tanquary, Jennifer
TI Impact of a Contextual Intervention on Child Participation and Parent
Competence Among Children With Autism Spectrum Disorders: A
Pretest-Posttest Repeated-Measures Design
SO AMERICAN JOURNAL OF OCCUPATIONAL THERAPY
LA English
DT Article
DE activities of daily living; autistic disorder; education; parenting;
professional-family relations; sensation; sensory threshold
ID INDEX-SHORT FORM; YOUNG-CHILDREN; SENSORY PROFILE; DEVELOPMENTAL
DISORDERS; CEREBRAL-PALSY; FAMILIES; STRESS; VALIDITY; THERAPY;
PERFORMANCE
AB OBJECTIVE. We tested an occupational therapy contextual intervention for improving participation in children with autism spectrum disorders and for developing parental competence.
METHOD. Using a repeated-measures pretest-posttest design, we evaluated the effectiveness of a contextually relevant reflective guidance occupational therapy intervention involving three components: authentic activity settings, family's daily routines, and the child's sensory processing patterns (Sensory Profile). We used these components to coach 20 parents in strategies to support their child's participation. Intervention sessions involved reflective discussion with parents to support them in identifying strategies to meet their goals and make joint plans for the coming week. We measured child participation (Canadian Occupational Performance Measure, Goal Attainment Scaling) and parent competence (Parenting Sense of Competence, Parenting Stress Index).
RESULTS. Results indicated that parents felt more competent and children significantly increased participation in everyday life, suggesting that this approach is an effective occupational therapy intervention.
C1 [Dunn, Winnie] Univ Kansas, Med Ctr, Sch Hlth Profess, Dept Occupat Therapy Educ, Kansas City, KS 66160 USA.
RP Dunn, W (reprint author), Univ Kansas, Med Ctr, Sch Hlth Profess, Dept Occupat Therapy Educ, 3033 Robinson Hall,Mailstop 2003,3901 Rainbow Blv, Kansas City, KS 66160 USA.
EM wdunn@kumc.edu
CR Abidin RR, 1995, PARENTING STRESS IND
Ackland R., 1991, J STAFF DEV, V12, P22
Bruder MB, 2010, EXCEPT CHILDREN, V76, P339
Coster W., 1988, SCH FUNCTION ASSESSM
Darrah J, 2011, DEV MED CHILD NEUROL, V53, P615, DOI 10.1111/j.1469-8749.2011.03959.x
DeGrace BW, 2004, AM J OCCUP THER, V58, P543
Dempsey I, 2004, J INTELLECT DEV DIS, V29, P40, DOI 10.1080/13668250410001662874
Doo S, 2006, DEV MED CHILD NEUROL, V48, P650, DOI 10.1017/S001216220600137X
Dunn W, 2001, AM J OCCUP THER, V55, P608
Dunn W, 1997, INFANT YOUNG CHILD, V9, P23
Dunn W., 2008, LIVING SENSATIONALLY
Dunn W, 2011, BEST PRACTICE OCCUPATIONAL THERAPY FOR CHILDREN AND FAMILIES IN COMMUNITY SETTINGS, SECOND EDITION, P1
Dunn W., 2010, AOTA SPEC C AUT BALT
Dunn W., 1999, SENSORY PROFILE MANU
Dunn W, 2002, AM J OCCUP THER, V56, P97
Dunst C. J., 2006, CORNERSTONES, V2, P1
Dunst C. J., 2006, J POLICY PRACT INTEL, V3, P3, DOI [10.1111/j.1741-1130.2006.00047.x, DOI 10.1111/J.1741-1130.2006.00047.X]
Engel-Yeger Batya, 2008, Can J Occup Ther, V75, P220
Gilmore L., 2008, CHILD CARE HLTH DEV, V35, P48
Graham F, 2010, PHYS OCCUP THER PEDI, V30, P4, DOI 10.3109/01942630903337536
Green S. B., 2011, USING SPSS WINDOWS M, V6th
Haskett ME, 2006, J CLIN CHILD ADOLESC, V35, P302, DOI 10.1207/s15374424jccp3502_14
Kientz MA, 1997, AM J OCCUP THER, V51, P530
King Gillian, 2003, Physical & Occupational Therapy in Pediatrics, V23, P63, DOI 10.1300/J006v23n01_05
King Susanne, 2004, Semin Pediatr Neurol, V11, P78, DOI 10.1016/j.spen.2004.01.009
LaVesser P, 2011, OTJR-OCCUP PART HEAL, V31, P33, DOI 10.3928/15394492-20100823-01
Law J, 2004, J SPEECH LANG HEAR R, V47, P924, DOI 10.1044/1092-4388(2004-069)
Law M., 2005, MEASURING OCCUPATION
Law M, 1998, CANADIAN OCCUPATIONA, V3rd
Law MC, 2011, DEV MED CHILD NEUROL, V53, P621, DOI 10.1111/j.1469-8749.2011.03962.x
McWilliam R. A., 2010, WORKING FAMILIES YOU
Miller LJ, 2007, AM J OCCUP THER, V61, P161
Mori K, 2009, PEDIATR INT, V51, P364, DOI 10.1111/j.1442-200X.2008.02728.x
Nachshen JS, 2005, J INTELL DISABIL RES, V49, P889, DOI 10.1111/j.1365-2788.2005.00721.x
Ohan JL, 2000, CAN J BEHAV SCI, V32, P251, DOI 10.1037/h0087122
Rogers H, 2004, AUST PSYCHOL, V39, P88, DOI 10.1080/00050060410001660380
Rogers SJ, 2003, J AUTISM DEV DISORD, V33, P631, DOI 10.1023/B:JADD.0000006000.38991.a7
Rush D. D., 2011, EARLY CHILDHOOD COAC
Schaaf RC, 2007, AM J OCCUP THER, V61, P239
Shani-Adir A, 2009, PEDIATR DERMATOL, V26, P143, DOI 10.1111/j.1525-1470.2009.00904.x
Spagnola M, 2007, INFANT YOUNG CHILD, V20, P284
Tomchek SD, 2007, AM J OCCUP THER, V61, P190
Watling RL, 2001, AM J OCCUP THER, V55, P416
Zaidman-Zait A, 2010, J CHILD PSYCHOL PSYC, V51, P1269, DOI 10.1111/j.1469-7610.2010.02266.x
NR 44
TC 9
Z9 9
PU AMER OCCUPATIONAL THERAPY ASSOC, INC
PI BETHESDA
PA 4720 MONTGOMERY LANE, BETHESDA, MD 20814-3425 USA
SN 0272-9490
J9 AM J OCCUP THER
JI Am. J. Occup. Ther.
PD SEP-OCT
PY 2012
VL 66
IS 5
SI SI
BP 520
EP 528
DI 10.5014/ajot.2012.004119
PG 9
WC Rehabilitation
SC Rehabilitation
GA 006RJ
UT WOS:000308836200004
PM 22917118
ER
PT J
AU Gutman, SA
Raphael-Greenfield, EI
Rao, AK
AF Gutman, Sharon A.
Raphael-Greenfield, Emily I.
Rao, Ashwini K.
TI Effect of a Motor-Based Role-Play Intervention on the Social Behaviors
of Adolescents With High-Functioning Autism: Multiple-Baseline
Single-Subject Design
SO AMERICAN JOURNAL OF OCCUPATIONAL THERAPY
LA English
DT Article
DE adolescent; autistic disorder; motor activity; role playing; social
behavior
ID MIRROR-NEURON SYSTEM; SPECTRUM DISORDERS; ASPERGER SYNDROME; CHILDREN;
TEENS
AB OBJECTIVE. We examined the effect of a motor-based role-play intervention on the social skills of adolescents with high-functioning autism.
METHOD. An ABA multiple-baseline design with three 3-mo phases occurring over 12 mo was used with 7 participants. Frequency of targeted verbal and nonverbal behaviors was tallied in each phase. Frequency data were analyzed using repeated-measures analyses of variance with post hoc comparisons to examine differences in targeted behaviors over the three phases.
RESULTS. Three participants completed all three study phases, 2 completed Phase 2, and 2 completed Phase 1. All participants (N = 7) demonstrated improved social skill use in Phase 1. Participants completing Phase 2 (n = 5) further improved social skill use. Additional improvements were observed among participants (n = 3) who completed Phase 3.
CONCLUSION. The intervention helped participants improve targeted social skill use. Further testing with larger samples and intervention modifications is warranted.
C1 [Gutman, Sharon A.; Raphael-Greenfield, Emily I.] Columbia Univ, Programs Occupat Therapy, New York, NY 10032 USA.
[Rao, Ashwini K.] Columbia Univ, Huntingtons Dis Ctr Excellence, Program Phys Therapy, New York, NY 10032 USA.
RP Gutman, SA (reprint author), Columbia Univ, Programs Occupat Therapy, 710 W 168th St,NI-8, New York, NY 10032 USA.
EM sg2422@columbia.edu
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
Barnhill G., 2002, FOCUS AUTISM OTHER D, V17, P112, DOI 10.1177/10883576020170020601
Bauminger N, 2002, J AUTISM DEV DISORD, V32, P283, DOI 10.1023/A:1016378718278
Bloom M., 2009, EVALUATING PRACTICE
Gentile A. M., 1998, SCANDINAVIAN J OCCUP, V5, P7, DOI 10.3109/11038129809035723
Gutman SA, 2010, OCCUP THER INT, V17, P188, DOI 10.1002/oti.300
Herbrecht E, 2009, EUR CHILD ADOLES PSY, V18, P327, DOI 10.1007/s00787-008-0734-4
Iacoboni M, 2006, NAT REV NEUROSCI, V7, P942, DOI 10.1038/nrn2024
Iacoboni M, 2007, ANN NEUROL, V62, P213, DOI 10.1002/ana.21198
Kogan MD, 2009, PEDIATRICS, V124, P1395, DOI 10.1542/peds.2009-1522
Laugeson EA, 2009, J AUTISM DEV DISORD, V39, P596, DOI 10.1007/s10803-008-0664-5
Leutenberg E. A., 2008, COMMUNICATION SKILLS
Liptak J. J., 2004, SOCIAL SKILLS PROGRA
MCCULLAGH P, 1989, EXERCISE SPORT SCI R, V17, P475
Myles B. S., 2004, HIDDEN CURRICULUM PR
Newschaffer CJ, 2007, ANNU REV PUBL HEALTH, V28, P235, DOI 10.1146/annurev.publhealth.28.021406.144007
Portney L. G., 2009, FDN CLIN RES APPL PR
Rizzolatti G, 2009, NAT CLIN PRACT NEURO, V5, P24, DOI 10.1038/ncpneuro0990
Rizzolatti G, 2004, ANNU REV NEUROSCI, V27, P169, DOI 10.1146/annurev.neuro.27.070203.144230
Rizzolatti G., 2010, 3 ANN F KAV LECT NEU
Rutter M, 2005, J INTELL DISABIL RES, V49, P231, DOI 10.1111/j.1365-2788.2005.00676.x
Solomon M, 2004, J AUTISM DEV DISORD, V34, P649, DOI 10.1007/s10803-004-5286-y
Tantam D, 2009, BRIT MED BULL, V89, P41, DOI 10.1093/bmb/ldp006
Thomeer M., 2006, FOCUS AUTISM OTHER D, V21, P237, DOI DOI 10.1177/10883576060210040501
Tse J, 2007, J AUTISM DEV DISORD, V37, P1960, DOI 10.1007/s10803-006-0343-3
Warren Z, 2011, PEDIATRICS, V127, pE1303, DOI 10.1542/peds.2011-0426
Webb B. J., 2004, FOCUS AUTISM OTHER D, V19, P53, DOI DOI 10.1177/10883576040190010701
White SW, 2010, CLIN CHILD FAM PSYCH, V13, P77, DOI 10.1007/s10567-009-0062-3
Williamson G. G., 2002, PROMOTING SOCIAL COM
Willingham DB, 1998, PSYCHOL REV, V105, P558, DOI 10.1037/0033-295X.105.3.558
Wulf G, 2010, MED EDUC, V44, P75, DOI 10.1111/j.1365-2923.2009.03421.x
NR 31
TC 2
Z9 2
PU AMER OCCUPATIONAL THERAPY ASSOC, INC
PI BETHESDA
PA 4720 MONTGOMERY LANE, BETHESDA, MD 20814-3425 USA
SN 0272-9490
J9 AM J OCCUP THER
JI Am. J. Occup. Ther.
PD SEP-OCT
PY 2012
VL 66
IS 5
SI SI
BP 529
EP 537
DI 10.5014/ajot.2012.003756
PG 9
WC Rehabilitation
SC Rehabilitation
GA 006RJ
UT WOS:000308836200005
PM 22917119
ER
PT J
AU Koenig, KP
Buckley-Reen, A
Garg, S
AF Koenig, Kristie Patten
Buckley-Reen, Anne
Garg, Satvika
TI Efficacy of the Get Ready to Learn Yoga Program Among Children With
Autism Spectrum Disorders: A Pretest-Posttest Control Group Design
SO AMERICAN JOURNAL OF OCCUPATIONAL THERAPY
LA English
DT Article
DE autistic disorder; child behavior; education, special; program
evaluation; yoga
ID RISPERIDONE
AB Occupational therapists use school-based yoga programs, but these interventions typically lack manualization and evidence from well-designed studies. Using an experimental pretest-posttest control group design, we examined the effectiveness of the Get Ready to Learn (GRTL) classroom yoga program among children with autism spectrum disorders (ASD). The intervention group received the manualized yoga program daily for 16 wk, and the control group engaged in their standard morning routine. We assessed challenging behaviors with standardized measures and behavior coding before and after intervention. We completed a between-groups analysis of variance to assess differences in gain scores on the dependent variables. Students in the GRTL program showed significant decreases (p < .05) in teacher ratings of maladaptive behavior, as measured with the Aberrant Behavior Checklist, compared with the control participants. This study demonstrates that use of daily classroomwide yoga interventions has a significant impact on key classroom behaviors among children with ASD.
C1 [Koenig, Kristie Patten; Garg, Satvika] NYU, Dept Occupat Therapy, New York, NY 10012 USA.
[Buckley-Reen, Anne] Kids OT PC, Ft Tilden, NY USA.
RP Koenig, KP (reprint author), NYU, Dept Occupat Therapy, 35 W 4th St, New York, NY 10012 USA.
EM kpk3@nyu.edu
CR Aman M., 1994, ABERRANT BEHAV CHECK
American Occupational Therapy Association, 2005, AM J OCCUPATIONAL TH, V59, P653, DOI DOI 10.5014/AJOT.59.6.653
Barnes PM, 2008, 12 CDC NAT HLTH STAT
Brinkley J, 2007, J AUTISM DEV DISORD, V37, P1949, DOI 10.1007/s10803-006-0327-3
Buckley-Reen A., 2009, GET READY LEARN
Centers for Disease Control and Prevention, 2009, MMWR-MORBID MORTAL W, V58, P1
Chan A, 2008, MIND BODY RELAXATION, P165
Chong C. S. M., 2011, J ALTERNATIVE THERAP, V17, P32
Dawson G., 2010, SOCIAL POLICY REPORT, V24, P22
Ehleringer J., 2010, INT J YOGA THERAPY, V20, P131
Ferguson CJ, 2009, PROF PSYCHOL-RES PR, V40, P532, DOI 10.1037/a0015808
Field Tiffany, 2011, Complement Ther Clin Pract, V17, P1, DOI 10.1016/j.ctcp.2010.09.007
Galantino Mary Lou, 2008, Pediatr Phys Ther, V20, P66, DOI 10.1097/PEP.0b013e31815f1208
Goldberg L., 2004, INT J YOGA THERAPY, V14, P68
Harrison L. J., 2004, CLIN CHILD PSYCHOL P, V9, P479, DOI DOI 10.1177/1359104504046155
Jensen Pauline S, 2004, J Atten Disord, V7, P205, DOI 10.1177/108705470400700403
Kenny M., 2002, INT J YOGA THERAPY, V12, P71
Khalsa S. B. S., 2011, J BEHAV HLTH SERVICE
Klatt M., 2009, EXPLORE-NY, V5, P152
Krisanaprakornkit T, 2010, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD006507.pub2
Krisanaprakornkit T, 2006, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD004998.pub2
Lin KY, 2011, EVID-BASED COMPL ALT, V2011
National Center for Complementary and Alternative Medicine, 2011, YOG HLTH INTR
Pandina GJ, 2007, J AUTISM DEV DISORD, V37, P367, DOI 10.1007/s10803-006-0234-7
Peck HL, 2005, SCHOOL PSYCHOL REV, V34, P415
Powell L, 2008, EUROPEAN J SPECIAL N, V23, P403, DOI 10.1080/08856250802387398
McCracken JT, 2002, NEW ENGL J MED, V347, P314, DOI 10.1056/NEJMoa013171
Sarris J., 2011, J AFFECTIVE DISORDER
Sparrow SS, 2005, VINELAND ADAPTIVE BE
Young Margaret B., 2012, Morbidity and Mortality Weekly Report, V61, P1
UMA K, 1989, J MENT DEFIC RES, V33, P415
Vancampfort D, 2011, DISABIL REHABIL, V33, P684, DOI 10.3109/09638288.2010.509458
NR 32
TC 4
Z9 4
PU AMER OCCUPATIONAL THERAPY ASSOC, INC
PI BETHESDA
PA 4720 MONTGOMERY LANE, BETHESDA, MD 20814-3425 USA
SN 0272-9490
J9 AM J OCCUP THER
JI Am. J. Occup. Ther.
PD SEP-OCT
PY 2012
VL 66
IS 5
SI SI
BP 538
EP 546
DI 10.5014/ajot.2012.004390
PG 9
WC Rehabilitation
SC Rehabilitation
GA 006RJ
UT WOS:000308836200006
PM 22917120
ER
PT J
AU Schaaf, RC
Hunt, J
Benevides, T
AF Schaaf, Roseann C.
Hunt, Joanne
Benevides, Teal
TI Occupational Therapy Using Sensory Integration to Improve Participation
of a Child With Autism: A Case Report
SO AMERICAN JOURNAL OF OCCUPATIONAL THERAPY
LA English
DT Article
DE activities of daily living; adaptation, psychological; autistic
disorder; interpersonal relations; occupational therapy; sensation
disorders
ID EXPERIENCES QUESTIONNAIRE; SPECTRUM DISORDERS; INTERVENTIONS; FIDELITY
AB In this case report, we describe the changes in adaptive behaviors and participation of 1 child with autism during a 10-wk program of intensive occupational therapy using a sensory integrative approach (OT-SI) following a manualized protocol. This case is part of a larger study examining the efficacy of the OT-SI approach. We found improvement in sensory processing, as measured by the Sensory Integration and Praxis Tests, as well as enhanced participation in home, school, and family activities, as indicated on parent-rated goal attainment scales.
C1 [Schaaf, Roseann C.; Benevides, Teal] Thomas Jefferson Univ, Dept Occupat Therapy, Jefferson Sch Hlth Profess, Philadelphia, PA 19107 USA.
[Schaaf, Roseann C.] Thomas Jefferson Univ, Farber Inst Neurosci, Philadelphia, PA 19107 USA.
[Hunt, Joanne] Childrens Specialized Hosp, Mountainside, NJ USA.
RP Schaaf, RC (reprint author), Thomas Jefferson Univ, Dept Occupat Therapy, Jefferson Sch Hlth Profess, 901 Walnut St,Room 605, Philadelphia, PA 19107 USA.
EM roseann.schaaf@jefferson.edu
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
Ayres A. J., 1989, SENSORY INTEGRATION
Ayres A. J., 1972, SENSORY INTEGRATION
Ayres A. J., 2005, SENSORY INTEGRATION, V25th
Baranek GT, 2006, J CHILD PSYCHOL PSYC, V47, P591, DOI 10.1111/j.1469-7610.2005.01546.x
Blanche E., 2006, SENSORY INTEGRATION, P91
Blanche E. I., 2001, CLIN OBSERVATIONS SE
Cohen I. L., 2005, PERVASIVE DEV BEHAV
Dunn W., 1999, SENSORY PROFILE
Gotham K, 2009, J AUTISM DEV DISORD, V39, P693, DOI 10.1007/s10803-008-0674-3
Kiresuk T, 1994, GOAL ATTAINMENT SCAL
Little LM, 2011, AM J OCCUP THER, V65, P207, DOI 10.5014/ajot.2011.000844
LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
Mailloux Z, 2007, AM J OCCUP THER, V61, P254
Mailloux Z, 2010, AUTISM COMPREHENSIVE, P469
May-Benson TA, 2010, AM J OCCUP THER, V64, P403, DOI 10.5014/ajot.2010.09071
Miller LJ, 2007, AM J OCCUP THER, V61, P228
Mulligan S, 1998, AM J OCCUP THER, V52, P819
Parham LD, 2011, AM J OCCUP THER, V65, P133, DOI 10.5014/ajot.2011.000745
Parham LD, 2007, AM J OCCUP THER, V61, P216
Perry A, 2009, J AUTISM DEV DISORD, V39, P1066, DOI 10.1007/s10803-009-0704-9
Pfeiffer BA, 2011, AM J OCCUP THER, V65, P76, DOI 10.5014/ajot.2011.09205
Roid G. H., 2003, STANFORD BINET INTEL
Schaaf R. C., 2010, SENSORY MOTOR UNPUB
Schaaf R. C., 2010, EVIDENCE BASED PRACT, P245
Schaaf RC, 2012, AM J OCCUP THER, V66, P503, DOI 10.5014/ajot.2012.006114
Smith T, 2007, J AUTISM DEV DISORD, V37, P354, DOI 10.1007/s10803-006-0173-3
Sparrow S. S., 2005, VINELAND ADAPTIVE BE
Sugai G, 2000, EXCEPTIONALITY, V8, P149
NR 30
TC 7
Z9 8
PU AMER OCCUPATIONAL THERAPY ASSOC, INC
PI BETHESDA
PA 4720 MONTGOMERY LANE, BETHESDA, MD 20814-3425 USA
SN 0272-9490
J9 AM J OCCUP THER
JI Am. J. Occup. Ther.
PD SEP-OCT
PY 2012
VL 66
IS 5
SI SI
BP 547
EP 555
DI 10.5014/ajot.2012.004473
PG 9
WC Rehabilitation
SC Rehabilitation
GA 006RJ
UT WOS:000308836200007
PM 22917121
ER
PT J
AU Mulligan, S
White, BP
AF Mulligan, Shelley
White, Barbara Prudhomme
TI Sensory and Motor Behaviors of Infant Siblings of Children With and
Without Autism
SO AMERICAN JOURNAL OF OCCUPATIONAL THERAPY
LA English
DT Article
DE autistic disorder; early diagnosis; motor activity; sensation; siblings
ID HIGH-FUNCTIONING AUTISM; SPECTRUM DISORDER; DEVELOPMENTAL DISORDERS;
MODIFIED CHECKLIST; HOME VIDEOTAPES; YOUNG-CHILDREN; AGE;
IDENTIFICATION; DIAGNOSIS; TODDLERS
AB We compared the sensory and motor behaviors of typically developing infants with those of infant siblings of children with autism spectrum disorders (ASD), who are considered high risk for the disorder, to explore potential sensory and motor markers for use in early diagnosis of ASD. We compared frequencies of sensory and motor behaviors during 10-min, videotaped, infant-mother play sessions and during 5 min of spoon-feeding between groups of 12-mo-old infants. Data from standardized measures of development, sensory processing, and behaviors commonly associated with ASD were also analyzed descriptively for the high-risk group. The results indicated that high-risk infants demonstrated fewer movement transitions (t [231 = -2.4, p = .03) and less object manipulation (t [23] = -2.4, p = .03) than low-risk infants. The sensory and motor differences found between typical and high-risk infants suggest that early screenings for ASD should include the examination of sensory and motor behaviors.
C1 [Mulligan, Shelley; White, Barbara Prudhomme] Univ New Hampshire, Dept Occupat Therapy, Durham, NH 03824 USA.
RP Mulligan, S (reprint author), Univ New Hampshire, Dept Occupat Therapy, Hewitt Hall, Durham, NH 03824 USA.
EM shelley.mulligan@unh.edu
CR Al-Qabandi M, 2011, PEDIATRICS, V128, pE211, DOI 10.1542/peds.2010-1881
American Psychiatric Association, 2000, DIAGN STAT MAN MENT
Baranek GT, 1999, J AUTISM DEV DISORD, V29, P213, DOI 10.1023/A:1023080005650
Baranek GT, 2002, J AUTISM DEV DISORD, V32, P397, DOI 10.1023/A:1020541906063
Baron-Cohen S, 2009, PHILOS T R SOC B, V364, P1377, DOI 10.1098/rstb.2008.0337
BARONCOHEN S, 1992, BRIT J PSYCHIAT, V161, P839, DOI 10.1192/bjp.161.6.839
Ben-Sasson A, 2009, J AUTISM DEV DISORD, V39, P1, DOI 10.1007/s10803-008-0593-3
Bryson SE, 2008, J AUTISM DEV DISORD, V38, P731, DOI 10.1007/s10803-007-0440-y
Bryson SE, 2007, J AUTISM DEV DISORD, V37, P12, DOI 10.1007/s10803-006-0328-2
Christensen L, 2010, J AUTISM DEV DISORD, V40, P946, DOI 10.1007/s10803-010-0941-y
Duby JC, 2006, PEDIATRICS, V118, P405, DOI 10.1542/peds.2006-1231
Dawson G, 2008, DEV PSYCHOPATHOL, V20, P775, DOI 10.1017/S0954579408000370
Dunn W, 2002, INFANT TODDLER SENSO
Feldman MA, 2012, J AUTISM DEV DISORD, V42, P13, DOI 10.1007/s10803-011-1208-y
Filipek PA, 1999, J AUTISM DEV DISORD, V29, P439, DOI 10.1023/A:1021943802493
Iverson JM, 2007, J AUTISM DEV DISORD, V37, P158, DOI 10.1007/s10803-006-0339-z
Jansiewicz EM, 2006, J AUTISM DEV DISORD, V36, P613, DOI 10.1007/s10803-006-0109-y
Johnson CP, 2007, PEDIATRICS, V120, P1183, DOI 10.1542/peds.2007-2361
Kogan MD, 2009, PEDIATRICS, V124, P1395, DOI 10.1542/peds.2009-1522
Landa R, 2006, J CHILD PSYCHOL PSYC, V47, P629, DOI 10.1111/j.1469-7610.2006.01531.x
Liu JJ, 2001, AM J HUM GENET, V69, P327, DOI 10.1086/321980
Loh A, 2007, J AUTISM DEV DISORD, V37, P25, DOI 10.1007/s10803-006-0333-5
Lord C., 2002, AUTISM DIAGNOSTIC OB
MCEACHIN JJ, 1993, AM J MENT RETARD, V97, P359
Minshew NJ, 2004, NEUROLOGY, V63, P2056
Molloy CA, 2003, J AUTISM DEV DISORD, V33, P643, DOI 10.1023/B:JADD.0000006001.00667.4c
Mullen E, 1995, MULLEN SCALES EARLY
Ospina MB, 2008, PLOS ONE, V3, DOI 10.1371/journal.pone.0003755
OSTERLING J, 1994, J AUTISM DEV DISORD, V24, P247, DOI 10.1007/BF02172225
Ozonoff S, 2008, J AUTISM DEV DISORD, V38, P644, DOI 10.1007/s10803-007-0430-0
Ozonoff S, 2008, AUTISM, V12, P457, DOI 10.1177/1362361308096402
Provost B, 2007, J AUTISM DEV DISORD, V37, P321, DOI 10.1007/s10803-006-0170-6
Rinehart NJ, 2001, J AUTISM DEV DISORD, V31, P79, DOI 10.1023/A:1005617831035
Robins DL, 2006, J DEV BEHAV PEDIATR, V27, pS111, DOI 10.1097/00004703-200604002-00009
Robins DL, 2001, J AUTISM DEV DISORD, V31, P131, DOI 10.1023/A:1010738829569
Rogers SJ, 2003, J AUTISM DEV DISORD, V33, P631, DOI 10.1023/B:JADD.0000006000.38991.a7
Sparrow S, 1984, VINELAND ADAPTIVE BE
Sullivan M, 2007, J AUTISM DEV DISORD, V37, P37, DOI 10.1007/s10803-006-0335-3
Teitelbaum P, 1998, P NATL ACAD SCI USA, V95, P13982, DOI 10.1073/pnas.95.23.13982
Young Margaret B., 2012, Morbidity and Mortality Weekly Report, V61, P1
Veness C, 2012, AUTISM, V16, P163, DOI 10.1177/1362361311399936
Werner E, 2000, J AUTISM DEV DISORD, V30, P157, DOI 10.1023/A:1005463707029
Yirmiya N, 2006, J CHILD PSYCHOL PSYC, V47, P511, DOI 10.1111/j.1469-7610.2005.01528.x
Yirmiya N, 2010, J CHILD PSYCHOL PSYC, V51, P432, DOI 10.1111/j.1469-7610.2010.02214.x
Young RL, 2003, AUTISM, V7, P125, DOI 10.1177/1362361303007002002
Zwaigenbaum L, 2007, J AUTISM DEV DISORD, V37, P466, DOI 10.1007/s10803-006-0179-x
Zwaigenbaum L, 2005, INT J DEV NEUROSCI, V23, P143, DOI 10.1016/j.ijdevneu.2004.05.001
NR 47
TC 8
Z9 8
PU AMER OCCUPATIONAL THERAPY ASSOC, INC
PI BETHESDA
PA 4720 MONTGOMERY LANE, BETHESDA, MD 20814-3425 USA
SN 0272-9490
J9 AM J OCCUP THER
JI Am. J. Occup. Ther.
PD SEP-OCT
PY 2012
VL 66
IS 5
SI SI
BP 556
EP 566
DI 10.5014/ajot.2012.004077
PG 11
WC Rehabilitation
SC Rehabilitation
GA 006RJ
UT WOS:000308836200008
PM 22917122
ER
PT J
AU Chang, MC
Parham, LD
Blanche, EI
Schell, A
Chou, CP
Dawson, M
Clark, F
AF Chang, Megan C.
Parham, L. Diane
Blanche, Erna Imperatore
Schell, Anne
Chou, Chih-Ping
Dawson, Michael
Clark, Florence
TI Autonomic and Behavioral Responses of Children With Autism to Auditory
Stimuli
SO AMERICAN JOURNAL OF OCCUPATIONAL THERAPY
LA English
DT Article
DE acoustic stimulation; autistic disorder; autonomic nervous system;
behavioral symptoms; galvanic skin response; sensation
ID SPECTRUM DISORDERS; ADULTS
AB OBJECTIVES. We examined whether children with and without autism spectrum disorder (ASD) differ in autonomic activity at rest and in response to auditory stimuli and whether behavioral problems related to sounds in everyday life are associated with autonomic responses to auditory stimuli.
METHOD. We measured skin conductance (SC) at rest and in response to auditory stimuli as well as behavioral responses using the Sensory Processing Measure (SPM) Home Form. Participants were 25 children with ASD and 25 typically developing (TD) children, aged 5-12 yr.
RESULTS. The ASD group had significantly higher resting SC and stronger SC reactivity to tones than the TD group. Correlations between SC and SPM indicated that more severe auditory behavioral difficulties were associated with higher sympathetic activation at rest and stronger sympathetic reactivity to sound.
CONCLUSION. High sympathetic reactivity to sound may underlie the difficult behavioral responses to sound that children with ASD often demonstrate.
C1 [Chang, Megan C.] San Jose State Univ, Dept Occupat Therapy, San Jose, CA 95192 USA.
[Parham, L. Diane] Univ New Mexico, Dept Pediat, Sch Med, Occupat Therapy Grad Program, Albuquerque, NM 87131 USA.
[Blanche, Erna Imperatore] Univ So Calif, Herman Ostrow Sch Dent, Div Occupat Sci & Occupat Therapy, Los Angeles, CA USA.
[Schell, Anne] Occidental Coll, Dept Psychol, Los Angeles, CA 90041 USA.
[Chou, Chih-Ping] Univ So Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA 90033 USA.
[Dawson, Michael] Univ So Calif, Dept Psychol, Los Angeles, CA 90089 USA.
[Clark, Florence] Univ So Calif, Herman Ostrow Sch Dent, Div Occupat Sci & Occupat Therapy, Los Angeles, CA USA.
RP Chang, MC (reprint author), San Jose State Univ, Dept Occupat Therapy, 1 Washington Sq, San Jose, CA 95192 USA.
EM megancchang@gmail.com
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
Baranek GT, 1997, OCCUP THER J RES, V17, P173
Baranek GT, 2006, J CHILD PSYCHOL PSYC, V47, P591, DOI 10.1111/j.1469-7610.2005.01546.x
BARRY RJ, 1988, INT J PSYCHOPHYSIOL, V6, P139, DOI 10.1016/0167-8760(88)90045-1
Boucsein W., 1992, ELECTRODERMAL ACTIVI
Comes E., 2004, ARQUIVOS NEUROPSIQUI, V62, P797
Crane L, 2009, AUTISM, V13, P215, DOI 10.1177/1362361309103794
Dawson ME, 2007, HANDBOOK OF PSYCHOPHYSIOLOGY, 3RD EDITION, P159
Dunn W, 2002, AM J OCCUP THER, V56, P97
FISHER LE, 1973, PSYCHOPHYSIOLOGY, V10, P578, DOI 10.1111/j.1469-8986.1973.tb00807.x
Greenspan S. I., 1997, J DEV LEARNING DISOR, V1, P87
Henry D. A., 2007, SENSORY PROCESSING M
JAMES A L, 1984, International Journal of Psychophysiology, V1, P179, DOI 10.1016/0167-8760(84)90037-0
Jasmin E, 2009, J AUTISM DEV DISORD, V39, P231, DOI 10.1007/s10803-008-0617-z
JOHNSON LC, 1963, SCIENCE, V139, P766, DOI 10.1126/science.139.3556.766
KOROL B, 1978, INTEGRATIVE PSYCHOL, V13, P121
Lane AE, 2010, J AUTISM DEV DISORD, V40, P112, DOI 10.1007/s10803-009-0840-2
Leekam SR, 2007, J AUTISM DEV DISORD, V37, P894, DOI 10.1007/s10803-006-0218-7
Miller L. J., 2001, UNDERSTANDING NATURE, P85
Miller LJ, 2000, SENSORY INTEGRATION, V23, P1
PALKOVITZ RJ, 1980, J AUTISM DEV DISORD, V10, P347, DOI 10.1007/BF02408294
Parham D. L., 2005, OCCUPATIONAL THERAPY, P356
Rogers SJ, 2003, J AUTISM DEV DISORD, V33, P631, DOI 10.1023/B:JADD.0000006000.38991.a7
Rogers SJ, 2005, J CHILD PSYCHOL PSYC, V46, P1255, DOI 10.1111/j.1469-7610.2005.01431.x
ROM DM, 1990, BIOMETRIKA, V77, P663, DOI 10.1093/biomet/77.3.663
Rutter M., 2003, SCQ SOCIAL COMMUNICA
Schoen SA, 2008, RES AUTISM SPECT DIS, V2, P417, DOI 10.1016/j.rasd.2007.09.002
Schoen S.A., 2009, FRONTIERS INTEGRATIV, V3, P1, DOI DOI 10.3389/NEURO.07.029.2009
STEVENS S, 1984, J AUTISM DEV DISORD, V14, P245, DOI 10.1007/BF02409577
VANENGELAND H, 1984, J AUTISM DEV DISORD, V14, P261
Venables PH, 1996, BIOL PSYCHOL, V43, P87, DOI 10.1016/0301-0511(96)05183-6
VOLKMAR FR, 1986, J AM ACAD CHILD PSY, V25, P190, DOI 10.1016/S0002-7138(09)60226-0
NR 32
TC 6
Z9 6
PU AMER OCCUPATIONAL THERAPY ASSOC, INC
PI BETHESDA
PA 4720 MONTGOMERY LANE, BETHESDA, MD 20814-3425 USA
SN 0272-9490
J9 AM J OCCUP THER
JI Am. J. Occup. Ther.
PD SEP-OCT
PY 2012
VL 66
IS 5
SI SI
BP 567
EP 576
DI 10.5014/ajot.2012.004242
PG 10
WC Rehabilitation
SC Rehabilitation
GA 006RJ
UT WOS:000308836200009
PM 22917123
ER
PT J
AU Flanagan, JE
Landa, R
Bhat, A
Bauman, M
AF Flanagan, Joanne E.
Landa, Rebecca
Bhat, Anjana
Bauman, Margaret
TI Head Lag in Infants at Risk for Autism: A Preliminary Study
SO AMERICAN JOURNAL OF OCCUPATIONAL THERAPY
LA English
DT Article
DE autistic disorder; infants; motor skills disorders; postural balance;
risk factor
ID MUSCLE POWER DEVELOPMENT; HIGH-FUNCTIONING AUTISM; SPECTRUM DISORDERS;
POSTURAL CONTROL; PRETERM INFANTS; DEVELOPMENTAL DISORDERS; MOTOR
DEVELOPMENT; 1ST YEAR; CHILDREN; IDENTIFICATION
AB OBJECTIVE. Poor postural control during pull-to-sit is a predictor of developmental disruption in cerebral palsy and preterm populations but has not been examined in infants at risk for autism. We examined the association between head lag during pull-to-sit at age 6 mo and autism risk status.
METHOD. High-risk participants were siblings of children with autism. We studied one sample of 40 high-risk infants prospectively from 6-36 mo and obtained diagnostic classifications of autism or no autism. We conducted a subsequent between-group comparison with a new sample of 20 high-risk and 21 low-risk infants.
RESULTS. Head lag was significantly associated with autism spectrum disorder at 36 mo (p=.020) and was more frequently observed in high-risk than in low-risk infants (p=.018).
CONCLUSION. Head lag with other alterations in early development may be associated with autism risk and may serve as an early indicator of neurodevelopmental disruption. Results have clinical implications for occupational therapists in early intervention practice.
C1 [Flanagan, Joanne E.; Landa, Rebecca] Kennedy Krieger Inst, Ctr Autism & Related Disorders, Baltimore, MD 21211 USA.
[Landa, Rebecca] Johns Hopkins Univ, Sch Med, Baltimore, MD USA.
[Bhat, Anjana] Univ Connecticut, Neag Sch Educ, Dept Kinesiol, Storrs, CT USA.
[Bauman, Margaret] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Lurie Ctr Autism, Cambridge, MA 02138 USA.
[Bauman, Margaret] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Dept Pediat & Neurol, Cambridge, MA 02138 USA.
RP Flanagan, JE (reprint author), Kennedy Krieger Inst, Ctr Autism & Related Disorders, 3901 Greenspring Ave, Baltimore, MD 21211 USA.
EM landa@kennedykrieger.org
CR ADRIEN JL, 1993, J AM ACAD CHILD PSY, V32, P617, DOI 10.1097/00004583-199305000-00019
American Psychiatric Association, 2000, DIAGN STAT MAN MENT
Barbosa VM, 2005, AM J OCCUP THER, V59, P446
Bhat AN, 2011, PHYS THER, V91, P1116, DOI 10.2522/ptj.20100294
Bly L, 1994, MOTOR SKILLS ACQUISI
Boulet SL, 2009, ARCH PEDIAT ADOL MED, V163, P19, DOI 10.1001/archpediatrics.2008.506
Bryson SE, 2007, J AUTISM DEV DISORD, V37, P12, DOI 10.1007/s10803-006-0328-2
Campos JJ, 2000, INFANCY, V1, P149, DOI 10.1207/S15327078IN0102_1
Charman T, 2005, J CHILD PSYCHOL PSYC, V46, P500, DOI 10.1111/j.1469-7610.2004.00377.x
de Groot L, 2000, DEV MED CHILD NEUROL, V42, P65, DOI 10.1017/S0012162200000128
Dowell LR, 2009, NEUROPSYCHOLOGY, V23, P563, DOI 10.1037/a0015640
Dziuk MA, 2007, DEV MED CHILD NEUROL, V49, P734
Einspieler C., 2004, PRECHTLS METHOD QUAL
Esposito G, 2009, BRAIN DEV-JPN, V31, P131, DOI 10.1016/j.braindev.2008.04.005
Flanagan J., 2007, AM OCC THER ASS ANN
Folio M. R., 1983, PEABODY DEV MOTOR SC
Fournier KA, 2010, J AUTISM DEV DISORD, V40, P1227, DOI 10.1007/s10803-010-0981-3
Hadders-Algra M, 2010, DEV MED CHILD NEUROL, V52, P87, DOI 10.1111/j.1469-8749.2009.03305.x
Hobson RP, 1999, J CHILD PSYCHOL PSYC, V40, P649, DOI 10.1111/1469-7610.00481
Hollingshead A. A., 1975, 4 FACTOR INDEX UNPUB
Iverson JM, 2010, J CHILD LANG, V37, P229, DOI 10.1017/S0305000909990432
Jansiewicz EM, 2006, J AUTISM DEV DISORD, V36, P613, DOI 10.1007/s10803-006-0109-y
Johnson CP, 2007, PEDIATRICS, V120, P1183, DOI 10.1542/peds.2007-2361
Kanner L, 1943, NERV CHILD, V2, P217
Landa R, 2006, J CHILD PSYCHOL PSYC, V47, P629, DOI 10.1111/j.1469-7610.2006.01531.x
Landa R. J., 2011, AUTISM SPECTRUM DISO, P213
Landa RJ, 2011, J CHILD PSYCHOL PSYC, V52, P13, DOI 10.1111/j.1469-7610.2010.02288.x
LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
Lord C., 2008, AUTISM DIAGNOSTIC OB
Lord C., 2002, AUTISM DIAGNOSTIC OB
Martineau J, 2004, NEUROSCI LETT, V367, P298, DOI 10.1016/j.neulet.2004.06.018
Minshew NJ, 2004, NEUROLOGY, V63, P2056
Molloy CA, 2003, J AUTISM DEV DISORD, V33, P643, DOI 10.1023/B:JADD.0000006001.00667.4c
Mullen E, 1995, MULLEN SCALES EARLY
NELLHAUS G, 1983, DEV MED CHILD NEUROL, V25, P384
Noterdaeme M, 2002, EUR CHILD ADOLES PSY, V11, P219, DOI 10.1007/s00787-002-0285-z
Ozonoff S, 2011, PEDIATRICS, V128, pE488, DOI 10.1542/peds.2010-2825
Ozonoff S, 2008, J AUTISM DEV DISORD, V38, P644, DOI 10.1007/s10803-007-0430-0
Ozonoff S, 2010, J AM ACAD CHILD PSY, V49, P256, DOI 10.1016/j.jaac.2009.11.009
Phagava H, 2008, GEORGIAN MED NEWS, V156, P100
Pierce K, 2001, BIOL PSYCHIAT, V49, P655, DOI 10.1016/S0006-3223(00)01008-8
Rinehart NJ, 2006, EUR CHILD ADOLES PSY, V15, P256, DOI 10.1007/s00787-006-0530-y
Rocha NACF, 2008, INFANT BEHAV DEV, V31, P107, DOI 10.1016/j.infbeh.2007.07.004
Rogers SJ, 2003, J CHILD PSYCHOL PSYC, V44, P763, DOI 10.1111/1469-7610.00162
Samsom JF, 2000, EARLY HUM DEV, V60, P101, DOI 10.1016/S0378-3782(00)00107-9
Samsom JF, 2002, EARLY HUM DEV, V68, P103, DOI 10.1016/S0378-3782(02)00019-1
Samson JF, 2002, DEV MED CHILD NEUROL, V44, P735
Schmitz C, 2003, NEUROSCI LETT, V348, P17, DOI 10.1016/S0304-3940(03)00644-X
Schmitz C., 2008, POSTURAL CONTROL KEY, P253
Sommerville J. A., 2005, COGNITION, V96, pB1, DOI DOI 10.1016/J.C0GNITI0N.2004.07.004
Soska KC, 2010, DEV PSYCHOL, V46, P129, DOI 10.1037/a0014618
Stone WL, 1999, J CHILD PSYCHOL PSYC, V40, P219, DOI 10.1017/S0021963098003370
Teitelbaum P, 1998, P NATL ACAD SCI USA, V95, P13982, DOI 10.1073/pnas.95.23.13982
Thelen E, 1998, NEUROSCI BIOBEHAV R, V22, P507, DOI 10.1016/S0149-7634(97)00037-7
Vernazza-Martin S, 2005, J AUTISM DEV DISORD, V35, P91, DOI 10.1007/s10803-004-1037-3
VILENSKY JA, 1981, ARCH NEUROL-CHICAGO, V38, P646
Zwaigenbaum L, 2005, INT J DEV NEUROSCI, V23, P143, DOI 10.1016/j.ijdevneu.2004.05.001
NR 57
TC 31
Z9 32
PU AMER OCCUPATIONAL THERAPY ASSOC, INC
PI BETHESDA
PA 4720 MONTGOMERY LANE, BETHESDA, MD 20814-3425 USA
SN 0272-9490
J9 AM J OCCUP THER
JI Am. J. Occup. Ther.
PD SEP-OCT
PY 2012
VL 66
IS 5
SI SI
BP 577
EP 585
DI 10.5014/ajot.2012.004192
PG 9
WC Rehabilitation
SC Rehabilitation
GA 006RJ
UT WOS:000308836200010
PM 22917124
ER
PT J
AU O'Donnell, S
Deitz, J
Kartin, D
Nalty, T
Dawson, G
AF O'Donnell, Shelley
Deitz, Jean
Kartin, Deborah
Nalty, Theresa
Dawson, Geraldine
TI Sensory Processing, Problem Behavior, Adaptive Behavior, and Cognition
in Preschool Children With Autism Spectrum Disorders
SO AMERICAN JOURNAL OF OCCUPATIONAL THERAPY
LA English
DT Article
DE adaptation, psychological; autistic disorder; child development
disorders, pervasive; behavior; sensation disorders
ID DEVELOPMENTAL DISORDERS; REPETITIVE BEHAVIORS; YOUNG-CHILDREN; SYMPTOMS;
ABNORMALITIES; INDIVIDUALS; TODDLERS; PROFILE
AB OBJECTIVE. This retrospective study explored sensory processing characteristics in preschool-age children with autism spectrum disorders (ASD); the relationships between sensory processing and problem behavior, adaptive behavior, and cognitive function; and the differences in sensory processing between two subgroups (autism and pervasive developmental disorder not otherwise specified).
METHOD. Study measures included the Short Sensory Profile (SSP), Aberrant Behavior Checklist-Community, Vineland Adaptive Behavior Scales, and Mullen Scales of Early Learning.
RESULTS. Most of the children with ASD had sensory processing challenges, and a significant relationship was found between SSP total scores and problem behavior scores; however, no significant relationships were found between SSP total scores and adaptive behavior and cognitive functioning. Although all the children had low Vineland scores, approximately one-quarter of the children had typical SSP scores. No significant differences in SSP scores were found between the subgroups.
CONCLUSION. The findings highlight the importance of comprehensive evaluations for children with ASD.
C1 [O'Donnell, Shelley] Seattle Therapy Serv, Seattle, WA 98102 USA.
[Deitz, Jean; Kartin, Deborah] Univ Washington, Dept Rehabil Med, Seattle, WA 98195 USA.
[O'Donnell, Shelley; Nalty, Theresa] Univ Washington, Autism Ctr, Seattle, WA USA.
[Dawson, Geraldine] Univ N Carolina, Dept Psychiat, Chapel Hill, NC USA.
RP O'Donnell, S (reprint author), Seattle Therapy Serv, 2517 Eastlake Ave E,Suite 102, Seattle, WA 98102 USA.
EM shelley@seattleot.com
CR Aman M., 1986, ABERRANT BEHAV CHECK
Aman M., 1994, ABERRANT BEHAV CHECK
American Occupational Therapy Association, 2008, AM J OCCUPATIONAL TH, V62, P625, DOI [10.5014/ajot.62.6.625, DOI 10.5014/AJOT.62.6.625]
American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th
Baker AEZ, 2008, J AUTISM DEV DISORD, V38, P867, DOI 10.1007/s10803-007-0459-0
Bayley N., 1969, BAYLEY SCALES INFANT
Ben-Sasson A, 2009, J AUTISM DEV DISORD, V39, P1, DOI 10.1007/s10803-008-0593-3
Ben-Sasson A, 2008, J CHILD PSYCHOL PSYC, V49, P817, DOI 10.1111/j.1469-7610.2008.01899.x
Centers for Disease Control and Prevention, 2009, MMWR-MORBID MORTAL W, V58, P1
Chen YH, 2009, J AUTISM DEV DISORD, V39, P635, DOI 10.1007/s10803-008-0663-6
DAHLGREN SO, 1989, EUR ARCH PSY CLIN N, V238, P169
Dawson G, 2000, J AUTISM DEV DISORD, V30, P415, DOI 10.1023/A:1005547422749
Dunn W, 1999, SENSORY PROFILE USER
Dunn W, 2002, AM J OCCUP THER, V56, P97
Gabriels RL, 2005, RES DEV DISABIL, V26, P169, DOI 10.1016/j.ridd.2004.05.003
Green VA, 2005, RES DEV DISABIL, V26, P47, DOI 10.1016/j.ridd.2004.07.003
Huebner R.A., 2001, AUTISM SENSORIMOTOR
Jasmin E, 2009, J AUTISM DEV DISORD, V39, P231, DOI 10.1007/s10803-008-0617-z
Kern JK, 2006, AUTISM, V10, P480, DOI 10.1177/1362361306066564
Kientz MA, 1997, AM J OCCUP THER, V51, P530
Lane AE, 2010, J AUTISM DEV DISORD, V40, P112, DOI 10.1007/s10803-009-0840-2
Liss M, 2006, AUTISM, V10, P155, DOI 10.1177/1362361306062021
Lord C., 1999, AUTISM DIAGNOSTIC OB
LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
Lord C, 1995, J CHILD PSYCHOL PSYC, V36, P1365, DOI 10.1111/j.1469-7610.1995.tb01669.x
McIntosh D. N., 1999, SENSORY PROFILE EXAM, P59
Miller LJ, 2000, SENSORY INTEGRATION, V23, P1
Miller LJ, 1999, AM J MED GENET, V83, P268, DOI 10.1002/(SICI)1096-8628(19990402)83:4<268::AID-AJMG7>3.3.CO;2-B
Mullen E, 1995, MULLEN SCALES EARLY
Rogers SJ, 2003, J AUTISM DEV DISORD, V33, P631, DOI 10.1023/B:JADD.0000006000.38991.a7
Schoen Sarah A, 2009, Front Integr Neurosci, V3, P29, DOI 10.3389/neuro.07.029.2009
Sigafoos J., 1997, BRIT J LEARNING DISA, V25, P13
Sparrow S, 1984, VINELAND ADAPTIVE BE
Watling RL, 2001, AM J OCCUP THER, V55, P416
Wiggins LD, 2009, J AUTISM DEV DISORD, V39, P1087, DOI 10.1007/s10803-009-0711-x
NR 36
TC 9
Z9 9
PU AMER OCCUPATIONAL THERAPY ASSOC, INC
PI BETHESDA
PA 4720 MONTGOMERY LANE, BETHESDA, MD 20814-3425 USA
SN 0272-9490
J9 AM J OCCUP THER
JI Am. J. Occup. Ther.
PD SEP-OCT
PY 2012
VL 66
IS 5
SI SI
BP 586
EP 594
DI 10.5014/ajot.2012.004168
PG 9
WC Rehabilitation
SC Rehabilitation
GA 006RJ
UT WOS:000308836200011
PM 22917125
ER
PT J
AU Lane, SJ
Reynolds, S
Dumenci, L
AF Lane, Shelly J.
Reynolds, Stacey
Dumenci, Levent
TI Sensory Overresponsivity and Anxiety in Typically Developing Children
and Children With Autism and Attention Deficit Hyperactivity Disorder:
Cause or Coexistence?
SO AMERICAN JOURNAL OF OCCUPATIONAL THERAPY
LA English
DT Article
DE anxiety; attention deficit disorder with hyperactivity; autistic
disorder; sensation disorders
ID PERVASIVE DEVELOPMENTAL DISORDERS; SPECTRUM DISORDERS;
OVER-RESPONSIVITY; ADHD; MODULATION; ABNORMALITIES; ADOLESCENTS;
DEPRESSION
AB OBJECTIVE. To explore the relationship between sensory overresponsivity (SOR) and anxiety in children with autism, attention deficit hyperactivity disorder, and typical development.
METHOD. Path analysis was used to examine the primary SOR model (Green & Ben-Sasson, 2010) using both physiological and behavioral data.
RESULTS. The magnitude of physiological responses to sensory challenge was a mediator variable between predictors (baseline arousal and attention) and outcomes (anxiety and physiological recovery). Behavioral SOR was correlated with anxiety but not with physiological variables.
CONCLUSION. The intensity or magnitude of sensory responsivity mediates the relationship between baseline arousal and attention and outcome anxiety and physiologic recovery from sensory challenge. Behavioral tools used to measure SOR do not reflect physiological responsiveness; this mismatch warrants further investigation. SOR can prevent children from participating in the occupations of childhood; the greater the understanding of SOR, the more successful occupational therapy practitioners will be in developing effective interventions.
C1 [Lane, Shelly J.; Reynolds, Stacey] Virginia Commonwealth Univ, Sch Allied Hlth Profess, Dept Occupat Therapy, Richmond, VA 23219 USA.
[Reynolds, Stacey] Univ Florida, Sch Publ Hlth & Hlth Profess, Dept Occupat Therapy, Gainesville, FL USA.
[Dumenci, Levent] Virginia Commonwealth Univ, Sch Med, Dept Social & Behav Hlth, Richmond, VA 23219 USA.
RP Lane, SJ (reprint author), Virginia Commonwealth Univ, Sch Allied Hlth Profess, Dept Occupat Therapy, 730 E Broad St,Suite 2050, Richmond, VA 23219 USA.
EM sjlane@vcu.edu
CR Abikoff H. B., 2002, J ABNORM PSYCHOL, V30, P1
ACHENBACH TM, 1987, PSYCHOL BULL, V101, P213, DOI 10.1037/0033-2909.101.2.213
Ayres A. J., 1972, SENSORY INTEGRATION
Baranek GT, 2006, J CHILD PSYCHOL PSYC, V47, P591, DOI 10.1111/j.1469-7610.2005.01546.x
Ben-Sasson A, 2009, J ABNORM CHILD PSYCH, V37, P705, DOI 10.1007/s10802-008-9295-8
Ben-Sasson A, 2009, J AUTISM DEV DISORD, V39, P1, DOI 10.1007/s10803-008-0593-3
Boucsein W., 1992, ELECTRODERMAL ACTIVI
Coster W., 1998, SCH FUNCTION ASSESSM
Dawson M. E., 1990, PRINCIPLES PSYCHOPHY, P294
Dawson ME, 2007, HANDBOOK OF PSYCHOPHYSIOLOGY, 3RD EDITION, P159
Dunn W, 2006, SENSORY PROFILE S
Dunn W, 2002, OTJR-OCCUP PARTICI H, V22, P4
Dunn W, 1999, SENSORY PROFILE USER
FOWLES DC, 1981, PSYCHOPHYSIOLOGY, V18, P232, DOI 10.1111/j.1469-8986.1981.tb03024.x
Grazer B., 1995, APOLLO 13
Green SA, 2010, J AUTISM DEV DISORD, V40, P1495, DOI 10.1007/s10803-010-1007-x
HIRAMATSU R, 1981, CLIN CHIM ACTA, V117, P239
Jensen PS, 2001, J AM ACAD CHILD PSY, V40, P147, DOI 10.1097/00004583-200102000-00009
JOHNSON FN, 1975, DIS NERV SYST, V36, P228
Joosten AV, 2010, AUST OCCUP THER J, V57, P366, DOI 10.1111/j.1440-1630.2009.00835.x
Kalpogianni D., 2002, BRIT J OCCUPATIONAL, V65, P475
Lane S. J., 2010, FRONTIERS INTEGRATIV, V4, P1
Lee G. P., 1988, NEUROPSY NEUROPSY BE, V1, P119
Leekam SR, 2007, J AUTISM DEV DISORD, V37, P894, DOI 10.1007/s10803-006-0218-7
Liss M, 2006, AUTISM, V10, P155, DOI 10.1177/1362361306062021
LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
MacKinnon D. P., 2008, INTRO STAT MEDIATION
MacNeil BM, 2009, RES AUTISM SPECT DIS, V3, P1, DOI 10.1016/j.rasd.2008.06.001
Mangeot SD, 2001, DEV MED CHILD NEUROL, V43, P399, DOI 10.1017/S0012162201000743
Mangina CA, 1996, INT J PSYCHOPHYSIOL, V22, P1, DOI 10.1016/0167-8760(96)00022-0
McIntosh D. N., 1999, SENSORY PROFILE EXAM, P59
McIntosh DN, 1999, DEV MED CHILD NEUROL, V41, P608, DOI 10.1017/S0012162299001267
Miller U., 2001, UNDERSTANDING NATURE, P57
Muris P, 2002, BEHAV RES THER, V40, P753, DOI 10.1016/S0005-7967(01)00056-0
Muthen L. K., 1998, MPLUS USERS GUIDE, V5th
Parush S, 2007, PHYSIOL BEHAV, V90, P553, DOI 10.1016/j.physbeh.2006.11.004
Pfeiffer B, 2005, AM J OCCUP THER, V59, P335
Pliszka Steven R, 2003, Paediatr Drugs, V5, P741, DOI 10.2165/00148581-200305110-00003
Reynolds C. R., 2005, REVISED CHILDRENS MA
Reynolds S., 2011, OTJR-OCCUP PART HEAL, V31, P246
Reynolds S, 2010, J ATTEN DISORD, V13, P468, DOI 10.1177/1087054708329906
Reynolds S, 2009, AM J OCCUP THER, V63, P433
Schatz David Beck, 2006, J Atten Disord, V10, P141, DOI 10.1177/1087054706286698
Schmidt NA, 1997, ISSUES COMPR PEDIAT, V20, P183
Schoen SA, 2008, AM J OCCUP THER, V62, P393
Schoen Sarah A, 2009, Front Integr Neurosci, V3, P29, DOI 10.3389/neuro.07.029.2009
Sequeira H, 2009, INT J PSYCHOPHYSIOL, V71, P50, DOI 10.1016/j.ijpsycho.2008.07.009
The Psychological Corporation, 1999, WECHSL ABBR SCAL INT
Tomchek SD, 2007, AM J OCCUP THER, V61, P190
Tsuji H, 2009, PSYCHIAT CLIN NEUROS, V63, P195, DOI 10.1111/j.1440-1819.2008.01916.x
White SW, 2009, CLIN PSYCHOL REV, V29, P216, DOI 10.1016/j.cpr.2009.01.003
Wright S. S., 1921, J AGR RES, V20, P557
Yochman A, 2004, AM J OCCUP THER, V58, P294
NR 54
TC 8
Z9 8
PU AMER OCCUPATIONAL THERAPY ASSOC, INC
PI BETHESDA
PA 4720 MONTGOMERY LANE, BETHESDA, MD 20814-3425 USA
SN 0272-9490
J9 AM J OCCUP THER
JI Am. J. Occup. Ther.
PD SEP-OCT
PY 2012
VL 66
IS 5
SI SI
BP 595
EP 603
DI 10.5014/ajot.2012.004523
PG 9
WC Rehabilitation
SC Rehabilitation
GA 006RJ
UT WOS:000308836200012
PM 22917126
ER
PT J
AU Kao, YC
Kramer, JM
Liljenquist, K
Tian, F
Coster, WJ
AF Kao, Ying-Chia
Kramer, Jessica M.
Liljenquist, Kendra
Tian, Feng
Coster, Wendy J.
TI Comparing the Functional Performance of Children and Youths With Autism,
Developmental Disabilities, and No Disability Using the Revised
Pediatric Evaluation of Disability Inventory Item Banks
SO AMERICAN JOURNAL OF OCCUPATIONAL THERAPY
LA English
DT Article
DE activities of daily living; adaptation, psychological; autistic
disorder; developmental disabilities; disability evaluation
ID ADAPTIVE-BEHAVIOR; PEDI-CAT; SPECTRUM DISORDERS; ADOLESCENTS; IQ
AB OBJECTIVE. We compared the functional performance of children with autism spectrum disorders (ASD), intellectual and developmental disabilities (IDD), and without disabilities using the revised Pediatric Evaluation of Disability Inventory-Computer Adaptive Test (PEDI-CAT) Social/Cognitive, Daily Activities, and Responsibility domains.
METHOD. A nationally representative sample of parents of children ages 0-21 without disabilities (n = 2,205), with ASD (n = 108), or with IDD (ri = 150) completed an online survey. We obtained predicted PEDI CAT scaled scores for three reference ages (5, 10, 15) from a modified analysis of covariance model and compared each group's scores using contrasts of the regression parameters.
RESULTS. We found no significant differences between the ASD and IDD groups. The group with ASD demonstrated significantly lower performance than the group without disabilities across the three domains at ages 10 and 15.
CONCLUSION. Scores on the PEDI CAT differentiated the group with ASD from the group without disabilities. Children with ASD and IDD did not demonstrate different performance profiles.
C1 [Kao, Ying-Chia; Liljenquist, Kendra] Boston Univ, Dept Occupat Therapy, Doctoral Program Rehabil Sci, Boston, MA 02215 USA.
[Tian, Feng] Boston Univ, Hlth & Disabil Res Inst, Sch Publ Hlth, Boston, MA 02215 USA.
RP Kao, YC (reprint author), Boston Univ, Dept Occupat Therapy, Doctoral Program Rehabil Sci, 635 Commonwealth Ave,SAR 552, Boston, MA 02215 USA.
EM yckao@bu.edu
CR Aiken L, 1991, MULTIPLE REGRESSION
Ben Itzchak E, 2011, RES AUTISM SPECT DIS, V5, P345, DOI 10.1016/j.rasd.2010.04.018
Carpentieri S, 1996, J AUTISM DEV DISORD, V26, P611, DOI 10.1007/BF02172350
de Bildt A, 2005, J INTELL DISABIL RES, V49, P672, DOI 10.1111/j.1365-2788.2005.00711.x
Dumas H, 2010, PHYS OCCUP THER PEDI, V30, P168, DOI 10.3109/01942631003640493
Dumas HM, 2012, DISABIL REHABIL, V34, P393, DOI 10.3109/09638288.2011.607217
Fenton G, 2003, AUTISM, V7, P269, DOI 10.1177/1362361303007003004
Fisch GS, 2002, J AUTISM DEV DISORD, V32, P107, DOI 10.1023/A:1014888505185
Gabriels RL, 2007, RES AUTISM SPECT DIS, V1, P291, DOI 10.1016/j.rasd.2006.11.004
Gleason K., J INTELLECTUAL DEV D
Haley SM, 2011, DEV MED CHILD NEUROL, V53, P1100, DOI 10.1111/j.1469-8749.2011.04107.x
Haley SM, 2012, PEDI CAT DEV STANDAR
Kleinbaum D, 1998, APPL REGRESSION ANAL, V3rd
Kramer JM, 2012, PHYS OCCUP THER PEDI, V32, P34, DOI 10.3109/01942638.2011.606260
Liss M, 2001, J AUTISM DEV DISORD, V31, P219, DOI 10.1023/A:1010707417274
LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
Mawhood L, 2000, J CHILD PSYCHOL PSYC, V41, P547, DOI 10.1017/S002196309900579X
McGovern CW, 2005, J CHILD PSYCHOL PSYC, V46, P401, DOI 10.1111/j.1469-7610.2004.00361.x
Perry A, 2009, J AUTISM DEV DISORD, V39, P1066, DOI 10.1007/s10803-009-0704-9
Piven J, 1996, J AM ACAD CHILD PSY, V35, P523, DOI 10.1097/00004583-199604000-00019
SCHATZ J, 1995, J AUTISM DEV DISORD, V25, P51, DOI 10.1007/BF02178167
Sparrow SS, 2005, VINELAND ADAPTIVE BE
Stone WL, 1999, AM J MENT RETARD, V104, P187, DOI 10.1352/0895-8017(1999)104<0187:POABIV>2.0.CO;2
World Health Organization, 2008, INT CLASS FUNCT DIS
NR 24
TC 4
Z9 4
PU AMER OCCUPATIONAL THERAPY ASSOC, INC
PI BETHESDA
PA 4720 MONTGOMERY LANE, BETHESDA, MD 20814-3425 USA
SN 0272-9490
J9 AM J OCCUP THER
JI Am. J. Occup. Ther.
PD SEP-OCT
PY 2012
VL 66
IS 5
SI SI
BP 607
EP 616
DI 10.5014/ajot.2012.004218
PG 10
WC Rehabilitation
SC Rehabilitation
GA 006RJ
UT WOS:000308836200013
PM 22917127
ER
PT J
AU Honaker, D
Rosello, SS
Candler, C
AF Honaker, DeLana
Rosello, Stacy Sue
Candler, Catherine
TI Test-Retest Reliability of Family LIFE (Looking Into Family
Experiences): An Occupation-Based Assessment
SO AMERICAN JOURNAL OF OCCUPATIONAL THERAPY
LA English
DT Article
DE activities of daily living; autistic disorder; family relations; human
activities; reproducibility of results; social participation
ID CONTEMPORARY PRACTICE; HOLISTIC APPROACH; ADAPTATION; CHILD
AB OBJECTIVE. We examined the test-retest reliability of Family L.I.F.E. (Looking Into Family Experiences) for consistency in identifying occupations desired by families with a child with autism spectrum disorder (ASD), and we compared the perceived efficiency, effectiveness, and satisfaction ratings of those occupations for the families.
METHOD. Family L.I.F.E. was administered initially and 1 wk later via interview to 13 families with a child with ASD.
RESULTS. Ninety-two percent of the families identified the same occupations as important at test and retest. Wilcoxon signed-rank test indicated no change in the families' perceived efficiency and effectiveness of those occupations, and Spearman's correlations indicated strong relationships. A decrease in satisfaction was noted.
CONCLUSION. For families with a child with ASD, desired family occupations and efficiency and effectiveness ratings are likely to remain consistent and are highly linked on retest using Family L.I.F.E. At second interview using this instrument, families with a child with ASD may report decreased satisfaction in desired family occupations.
C1 [Rosello, Stacy Sue] Embrace Child Ltd, Pittsburgh, PA USA.
[Candler, Catherine] Texas Womans Univ, Sch Occupat Therapy, Dallas, TX USA.
RP Honaker, D (reprint author), 4304 Mesa Circle, Amarillo, TX 79109 USA.
EM delanah@delanah.com
CR American Occupational Therapy Association, 2008, AM J OCCUPATIONAL TH, V62, P625, DOI [10.5014/ajot.62.6.625, DOI 10.5014/AJOT.62.6.625]
Case-Smith J, 2004, AM J OCCUP THER, V58, P551
Cup EHC, 2003, CLIN REHABIL, V17, P402, DOI 10.1191/0269215503cr635oa
DeGrace BW, 2004, AM J OCCUP THER, V58, P543
DeLizzio A., 2008, THESIS VIRGINIA COMM
Dunst C. J., 2002, J SPEC EDUC, V36, P141, DOI [10.1177/00224669020360030401, DOI 10.1177/00224669020360030401]
Fiese BH, 2006, NEW DIR CHILD ADOLES, V111, P67, DOI 10.1002/cad.155
Honaker D., 2008, ELIZABETHTOWN COLL J, P69
Honaker D., 2009, ELIZABETHTOWN COLL J, P2
Honaker D., 2006, ELIZABETHTOWN COLL J, P2
Humphry R, 2004, AM J OCCUP THER, V58, P487
SCHULTZ S, 1992, AM J OCCUP THER, V46, P917
SCHKADE JK, 1992, AM J OCCUP THER, V46, P829
Segal R., 1999, J OCCUPATIONAL SCI, V6, P53
Sing J, 2001, BRIT J OCCUPATIONAL, V64, P305
NR 15
TC 1
Z9 1
PU AMER OCCUPATIONAL THERAPY ASSOC, INC
PI BETHESDA
PA 4720 MONTGOMERY LANE, BETHESDA, MD 20814-3425 USA
SN 0272-9490
J9 AM J OCCUP THER
JI Am. J. Occup. Ther.
PD SEP-OCT
PY 2012
VL 66
IS 5
SI SI
BP 617
EP 620
DI 10.5014/ajot.2012.004002
PG 4
WC Rehabilitation
SC Rehabilitation
GA 006RJ
UT WOS:000308836200014
PM 22917128
ER
PT J
AU Blanche, EI
Reinoso, G
Chang, MC
Bodison, S
AF Blanche, Erna Imperatore
Reinoso, Gustavo
Chang, Megan C.
Bodison, Stefanie
TI Proprioceptive Processing Difficulties Among Children With Autism
Spectrum Disorders and Developmental Disabilities
SO AMERICAN JOURNAL OF OCCUPATIONAL THERAPY
LA English
DT Article
DE autistic disorder; developmental disabilities; feedback, sensory;
proprioception; somatosensory disorders
ID EXPERIENCES; DEFICIT
AB OBJECTIVE. Sensory processing difficulties among children with autism spectrum disorders (ASD) have been extensively documented. However, less is known about this population's ability to process proprioceptive information.
METHOD. We used the Comprehensive Observations of Proprioception (COP; Blanche, Bodison, Chang, & Reinoso, in press) to describe the proprioceptive difficulties experienced by children with ASD. A sample of 32 children with ASD, 26 children with developmental disabilities excluding ASD, and 28 typically developing control children were studied using the COP.
RESULTS. Children with ASD present with proprioceptive processing difficulties that are different from those of children with developmental disabilities and their typically developing counterparts. Specific data, potential clinical applications, and directions for future research are described.
CONCLUSION. Results suggest that the COP has useful clinical research applications. Further assessment of psychometric properties, clinical utility, and meaningful differences among diverse clinical populations are needed.
C1 [Blanche, Erna Imperatore] Univ So Calif, Div Occupat Sci & Occupat Therapy, Los Angeles, CA 90089 USA.
[Reinoso, Gustavo] Adv Therapy Syst, Dundalk, County Louth, Ireland.
[Chang, Megan C.] San Jose State Univ, Dept Occupat Therapy, San Jose, CA 95192 USA.
[Bodison, Stefanie] Univ So Calif, Div Occupat Sci & Occupat Therapy, Los Angeles, CA USA.
RP Blanche, EI (reprint author), Univ So Calif, Div Occupat Sci & Occupat Therapy, 1540 Alcazar,CHP-133, Los Angeles, CA 90089 USA.
EM blanche@usc.edu
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
Ayres A. J., 1989, SENSORY INTEGRATION
Ayres A. J., 1972, SENSORY INTEGRATION
Baranek GT, 1997, AM J OCCUP THER, V51, P91
Baranek GT, 2006, J CHILD PSYCHOL PSYC, V47, P591, DOI 10.1111/j.1469-7610.2005.01546.x
Ben-Sasson A, 2009, J AUTISM DEV DISORD, V39, P1, DOI 10.1007/s10803-008-0593-3
Blanche E. I., AM J OCCUPA IN PRESS
Dunn W, 2001, AM J OCCUP THER, V55, P608
Dunn W., 1999, SENSORY PROFILE
DUNNETT CW, 1980, J AM STAT ASSOC, V75, P789, DOI 10.2307/2287160
Fuentes CT, 2011, J AUTISM DEV DISORD, V41, P1352, DOI 10.1007/s10803-010-1161-1
Glazebrook CM, 2009, AUTISM, V13, P411, DOI 10.1177/1362361309105659
Grob KR, 2002, J BONE JOINT SURG BR, V84B, P614, DOI 10.1302/0301-620X.84B4.11241
Haswell CC, 2009, NAT NEUROSCI, V12, P970, DOI 10.1038/nn.2356
Henry D. A., 2007, SENSORY PROCESSING M
Jones RSP, 2003, J INTELLECT DEV DIS, V28, P112, DOI 10.1080/1366825031000147058
KRAMER CY, 1956, BIOMETRICS, V12, P307, DOI 10.2307/3001469
Leekam SR, 2007, J AUTISM DEV DISORD, V37, P894, DOI 10.1007/s10803-006-0218-7
Lephart SM, 2000, PROPRIOCEPTION NEURO
Mukhopadhyay T., 2003, MIND TREE
Schmitz C, 2003, NEUROSCI LETT, V348, P17, DOI 10.1016/S0304-3940(03)00644-X
Smith Roley S., 2001, UNDERSTANDING NATURE, P109
Vakalopoulos C, 2007, MED HYPOTHESES, V68, P574, DOI 10.1016/j.mehy.2006.08.013
Weimer AK, 2001, J DEV BEHAV PEDIATR, V22, P92
NR 24
TC 4
Z9 4
PU AMER OCCUPATIONAL THERAPY ASSOC, INC
PI BETHESDA
PA 4720 MONTGOMERY LANE, BETHESDA, MD 20814-3425 USA
SN 0272-9490
J9 AM J OCCUP THER
JI Am. J. Occup. Ther.
PD SEP-OCT
PY 2012
VL 66
IS 5
SI SI
BP 621
EP 624
DI 10.5014/ajot.2012.004234
PG 4
WC Rehabilitation
SC Rehabilitation
GA 006RJ
UT WOS:000308836200015
PM 22917129
ER
PT J
AU Chhor, V
Schang, AL
Favrais, G
Fleiss, B
Gressens, P
AF Chhor, V.
Schang, A. -L.
Favrais, G.
Fleiss, B.
Gressens, P.
TI Long-term cerebral effects of perinatal inflammation
SO ARCHIVES DE PEDIATRIE
LA French
DT Article
ID TRAUMATIC BRAIN-INJURY; PROGRAMMED CELL-DEATH; BIRTH-WEIGHT INFANTS;
WHITE-MATTER INJURY; SYSTEMIC INFLAMMATION; DEVELOPMENTAL REGULATION;
MICROGLIAL ACTIVATION; HYPOXIA-ISCHEMIA; IMMATURE BRAIN; PRETERM
AB Perinatal inflammation can lead to fetal/neonatal inflammatory syndrome, a risk factor for brain lesions, especially in the white matter. Perinatal inflammation is associated with increased incidence of cerebral palsy in humans and animal models and there is a strong relationship with increased incidence of autism and schizophrenia in humans. Perinatal inflammation causes acute microglial and astroglial activation, blood-brain barrier dysfunction, and disrupts oligodendrocyte maturation leading to hypomyelination. Inflammation also sensitizes the brain to additional perinatal insults, including hypoxia-ischemia. Furthermore, long after the primary cause of inflammation has resolved, gliosis may also persist and predispose to neurodegenerative diseases including Alzheimer's and Parkinson's disease, but this relation is still hypothetical. Finding of acute and chronic changes in brain structure and function due to perinatal inflammation highlights the need for treatments. As gliosis appears to be involved in the acute and chronic effects of perinatal inflammation, modulating the glial phenotype may be an effective strategy to prevent damage to the brain. (c) 2012 Published by Elsevier Masson SAS.
C1 [Chhor, V.; Schang, A. -L.; Fleiss, B.; Gressens, P.] Hop Robert Debre, Inserm U676, F-75019 Paris, France.
[Chhor, V.; Schang, A. -L.; Fleiss, B.; Gressens, P.] Univ Paris 07, Fac Med Denis Diderot, F-75205 Paris 13, France.
[Chhor, V.; Schang, A. -L.; Fleiss, B.; Gressens, P.] PremUP, F-75006 Paris, France.
[Favrais, G.] Univ Tours, Hop Clocheville, CHRU Tours, F-37000 Tours, France.
[Fleiss, B.; Gressens, P.] Imperial Coll, Ctr Developing Brain, London W12 OHS, Royaume Uni, England.
RP Gressens, P (reprint author), Hop Robert Debre, Inserm U676, 48 Blvd Serurier, F-75019 Paris, France.
EM pierre.gressens@inserm.fr
RI Fleiss, Bobbi/F-9899-2011
CR Aden U, 2010, BRAIN BEHAV IMMUN, V24, P747, DOI 10.1016/j.bbi.2009.10.010
Beschorner R, 2002, ACTA NEUROPATHOL, V103, P541, DOI 10.1007/s00401-001-0503-7
Bezzi P, 2001, NAT NEUROSCI, V4, P702, DOI 10.1038/89490
Brochu ME, 2011, J NEUROINFLAMM, V8, DOI 10.1186/1742-2094-8-55
Cacci E, 2008, GLIA, V56, P412, DOI 10.1002/glia.20616
Choi Ehn-Kyoung, 2011, Lab Anim Res, V27, P77, DOI 10.5625/lar.2011.27.2.77
Clausen F, 2011, EUR J NEUROSCI, V34, P110, DOI 10.1111/j.1460-9568.2011.07723.x
Dean JM, 2011, ANN NEUROL, V70, P846, DOI 10.1002/ana.22480
Debillon T, 2000, PEDIATR RES, V47, P736, DOI 10.1203/00006450-200006000-00009
Dommergues MA, 2000, ANN NEUROL, V47, P54, DOI 10.1002/1531-8249(200001)47:1<54::AID-ANA10>3.0.CO;2-Y
Eklind S, 2001, EUR J NEUROSCI, V13, P1101, DOI 10.1046/j.0953-816x.2001.01474.x
Ellis S, 2005, FASEB J, V19, P1519, DOI 10.1096/fj.04-3569fje
Fatemi SH, 2002, CELL MOL NEUROBIOL, V22, P25, DOI 10.1023/A:1015337611258
Favrais G, 2011, ANN NEUROL, V70, P550, DOI 10.1002/ana.22489
Fontaine RH, 2008, P NATL ACAD SCI USA, V105, P16779, DOI 10.1073/pnas.0803004105
Galic MA, 2008, J NEUROSCI, V28, P6904, DOI 10.1523/JNEUROSCI.1901-08.2008
GILLES FH, 1977, ANN NEUROL, V2, P49, DOI 10.1002/ana.410020108
Girard S, 2010, J IMMUNOL, V184, P3997, DOI 10.4049/jimmunol.0903349
Glass HC, 2008, PEDIATRICS, V122, P299, DOI 10.1542/peds.2007-2184
Griffin R, 2006, J NEUROCHEM, V99, P1263, DOI 10.1111/j.1471-4159.2006.04165.x
Hansen-Pupp I, 2008, PEDIATR RES, V64, P183, DOI 10.1203/PDR.0b013e318176144d
Hendson L, 2011, J PEDIATR-US, V158, P397, DOI 10.1016/j.jpeds.2010.09.010
Hintz SR, 2005, PEDIATRICS, V115, P696, DOI 10.1542/peds.2004-0569
Holmes C, 2009, NEUROLOGY, V73, P768, DOI 10.1212/WNL.0b013e3181b6bb95
Huang ZH, 2009, BRAIN RES, V1301, P100, DOI 10.1016/j.brainres.2009.09.006
Juurlink BHJ, 1997, NEUROSCI BIOBEHAV R, V21, P151, DOI 10.1016/S0149-7634(96)00005-X
Kannan S, 2011, DEV NEUROSCI-BASEL, V33, P231, DOI 10.1159/000328125
Kigerl KA, 2009, J NEUROSCI, V29, P13435, DOI 10.1523/JNEUROSCI.3257-09.2009
Leviton A, 2011, CYTOKINE, V53, P66, DOI 10.1016/j.cyto.2010.09.003
Lin CY, 2010, ANN NEUROL, V68, P204, DOI 10.1002/ana.22049
Martin CR, 2010, J PEDIATR-US, V157, P751, DOI 10.1016/j.jpeds.2010.05.042
Meyer U, 2006, J NEUROSCI, V26, P4752, DOI 10.1523/JNEUROSCI.0099-06.2006
Meyer U, 2009, PSYCHOPHARMACOLOGY, V206, P587, DOI 10.1007/s00213-009-1504-9
Mildner A, 2011, J NEUROSCI, V31, P11159, DOI 10.1523/JNEUROSCI.6209-10.2011
Moreno B, 2011, ANN NEUROL, V70, P932, DOI 10.1002/ana.22550
Mosser DM, 2008, NAT REV IMMUNOL, V8, P958, DOI 10.1038/nri2448
Nagamoto-Combs K, 2007, J NEUROTRAUM, V24, P1719, DOI 10.1089/neu.2007.0377
Nelson KB, 1998, ANN NEUROL, V44, P665, DOI 10.1002/ana.410440413
Nijboer CHA, 2008, J NEUROSCI, V28, P3324, DOI 10.1523/JNEUROSCI.4769-07.2008
Normann E, 2009, PEDIATR RES, V65, P430, DOI 10.1203/PDR.0b013e31819984ce
Pang Y, 2003, DEV BRAIN RES, V140, P205, DOI 10.1016/S0165-3806(02)00606-5
Pang Y, 2010, NEUROSCIENCE, V166, P464, DOI 10.1016/j.neuroscience.2009.12.040
Paolicelli RC, 2011, SCIENCE, V333, P1456, DOI 10.1126/science.1202529
Ramlackhansingh AF, 2011, ANN NEUROL, V70, P374, DOI 10.1002/ana.22455
Romero E, 2010, MOL PSYCHIATR, V15, P372, DOI 10.1038/mp.2008.44
Rousset CI, 2006, PEDIATR RES, V59, P428, DOI 10.1203/01.pdr.0000199905.08848.55
Schlapbach U, 2011, PEDIATRICS, V128, pe348
Shatrov JG, 2010, OBSTET GYNECOL, V116, P387
Sloane JA, 2010, P NATL ACAD SCI USA, V107, P11555, DOI 10.1073/pnas.1006496107
Sofroniew MV, 2009, TRENDS NEUROSCI, V32, P638, DOI 10.1016/j.tins.2009.08.002
Stoll BJ, 2004, JAMA-J AM MED ASSOC, V292, P2357, DOI 10.1001/jama.292.19.2357
Stolp HB, 2005, EUR J NEUROSCI, V22, P2805, DOI 10.1111/j.1460-9568.2005.04483.x
Vargas DL, 2005, ANN NEUROL, V57, P67, DOI 10.1002/ana.20315
Venturi L, 2009, J NEUROTRAUM, V26, P1547, DOI 10.1089/neu.2008-0723
Wang XY, 2009, J CHILD NEUROL, V24, P1171, DOI 10.1177/0883073809338068
Yoon BH, 1997, AM J OBSTET GYNECOL, V177, P406, DOI 10.1016/S0002-9378(97)70206-0
Zhao XH, 2010, NEURON, V65, P612, DOI 10.1016/j.neuron.2010.02.018
NR 57
TC 2
Z9 2
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI PARIS
PA 23 RUE LINOIS, 75724 PARIS, FRANCE
SN 0929-693X
J9 ARCH PEDIATRIE
JI Arch. Pediatr.
PD SEP
PY 2012
VL 19
IS 9
BP 946
EP 952
DI 10.1016/j.arcped.2012.06.013
PG 7
WC Pediatrics
SC Pediatrics
GA 002FD
UT WOS:000308516500010
PM 22885003
ER
PT J
AU Ouss-Ryngaert, L
Alvarez, L
Boissel, A
AF Ouss-Ryngaert, L.
Alvarez, L.
Boissel, A.
TI Autism and prematurity: State of the art
SO ARCHIVES DE PEDIATRIE
LA French
DT Article
ID LOW-BIRTH-WEIGHT; PRETERM INFANTS; CHILDREN BORN; SPECTRUM DISORDER;
RISK-FACTORS; PREVALENCE; AGE; BEHAVIOR; OUTCOMES; CONSEQUENCES
AB Research has shown a high rate of autism spectrum disorders among very low birth weight children over the past decade. This paper proposes a literature review on this topic. Two generations of research have followed one another. The first retrospective studies found a high rate of ASD among premature babies. The second generation of prospective studies underlined and relativized this risk. Prospective research using screening tools (M-CHAT) have found around 20 % ASD, whereas 2 studies assessing the actual diagnosis found 5 % and 8 % ASD, 10 to 12 times more than in the general population. A number of hypotheses have been put forward to explain these high rates of ASD: sensory impairment associated with prematurity, white matter abnormalities, and cerebellar impairment. The authors propose complex models that take into account neurological deficits and the effects of perinatal events on interactive dynamics between infants and their caregivers. These models aim to allow suitable prevention and care for premature children with autism, a heavy additional handicap. (C) 2012 Published by Elsevier Masson SAS.
C1 [Ouss-Ryngaert, L.] Hop Necker Enfants Malad, Serv Neuropediat, F-75015 Paris, France.
[Alvarez, L.] IPP, Serv Pedopsychiat, Paris, France.
[Boissel, A.] Univ Caen, Lab CERRReV, F-14032 Caen, France.
RP Ouss-Ryngaert, L (reprint author), Hop Necker Enfants Malad, Serv Neuropediat, 149 Rue Sevres, F-75015 Paris, France.
EM lisa.ouss@wanadoo.fr
CR Alvarez L, 2010, PSYCHIAT ENFANT, V53, P609, DOI 10.3917/psye.532.0609
Anderson P, 2003, JAMA-J AM MED ASSOC, V289, P3264, DOI 10.1001/jama.289.24.3264
Assaf M, 2010, NEUROIMAGE, V53, P247, DOI 10.1016/j.neuroimage.2010.05.067
Beckwith L, 1996, INF MENTAL HLTH J, V17, P322
Bhutta AT, 2002, JAMA-J AM MED ASSOC, V288, P728, DOI 10.1001/jama.288.6.728
Boardman JP, 2010, NEUROIMAGE, V52, P409, DOI 10.1016/j.neuroimage.2010.04.261
Buchmayer S, 2009, PEDIATRICS, V124, pE817, DOI 10.1542/peds.2008-3582
Chapieski ML, 1997, SEMIN PERINATOL, V21, P221, DOI 10.1016/S0146-0005(97)80065-1
Courchesne E, 1999, NEUROLOGY, V52, P1106
Croen LA, 2002, J AUTISM DEV DISORD, V32, P207, DOI 10.1023/A:1015453830880
De Ajuriaguerra J, 1980, MANUEL PSYCHIAT ENFA
Feldman R, 2007, DEV PSYCHOBIOL, V49, P290, DOI 10.1002/dev.20220
Fombonne E, 2005, J CLIN PSYCHIAT, V66, P3
Glasson EJ, 2004, ARCH GEN PSYCHIAT, V61, P618, DOI 10.1001/archpsyc.61.6.618
Golse B, 2006, ETRE BEBE FIL ROUGE
Halsey CL, 1996, ARCH PEDIAT ADOL MED, V150, P790
Hille ETM, 2001, LANCET, V357, P1641, DOI 10.1016/S0140-6736(00)04818-2
Hultman CM, 2002, EPIDEMIOLOGY, V13, P417, DOI 10.1097/01.EDE.0000016968.14007.E6
Indredavik M. S., 2004, ARCH DIS CHILD-FETAL, V89, P445
Johnson S, 2010, J PEDIATR-US, V156, P525, DOI 10.1016/j.jpeds.2009.10.041
Johnson S, 2009, J PEDIATR-US, V154, P478, DOI 10.1016/j.jpeds.2008.11.028
Knoester M, 2007, HUM REPROD, V22, P3098, DOI 10.1093/humrep/dem261
Kuban KC, 2009, J PEDIAT, V154, P534
Landry SH, 1997, J CLIN EXP NEUROPSYC, V19, P261, DOI 10.1080/01688639708403856
Landry SH, 2003, DEV NEUROPSYCHOL, V24, P559, DOI 10.1207/S15326942DN242&3_04
Larroque B, 2004, ARCH DIS CHILD, V89, P139, DOI 10.1136/adc.2002.020396
Limperopoulos C, 2009, CLIN PERINATOL, V36, P791, DOI 10.1016/j.clp.2009.07.010
Limperopoulos C, 2005, PEDIATRICS, V115, P688, DOI 10.1542/peds.2004-1169
Limperopoulos C, 2008, PEDIATRICS, V121, P758, DOI 10.1542/peds.2007-2158
Limperopoulos C, 2007, PEDIATRICS, V120, P584, DOI 10.1542/peds.2007-1041
Miceli PJ, 2000, J PEDIATR PSYCHOL, V25, P353, DOI 10.1093/jpepsy/25.5.353
Moster D, 2008, NEW ENGL J MED, V359, P262, DOI 10.1056/NEJMoa0706475
Msall ME, 2004, PEDIATRICS, V113, P790, DOI 10.1542/peds.113.4.790
Muller-Nix C, 2009, PSYCHIAT ENFANT, V52, P423
PATTESON DM, 1990, INF MENTAL HLTH J, V11, P37, DOI 10.1002/1097-0355(199021)11:1<37::AID-IMHJ2280110105>3.0.CO;2-2
Peterson BS, 2003, ANN NY ACAD SCI, V1008, P219, DOI 10.1196/annals.1301.023
Pinto-Martin JA, 2011, PEDIATRICS, V128, P883, DOI 10.1542/peds.2010-2846
Samara M, 2008, PEDIATRICS, V122, P562, DOI 10.1542/peds.2007-3231
Skranes J, 2007, BRAIN, V130, P654, DOI 10.1093/brain/awm001
Wood NS, 2000, NEW ENGL J MED, V343, P378, DOI 10.1056/NEJM200008103430601
Zelkowitz P, 2009, EARLY HUM DEV, V85, P51, DOI 10.1016/j.earlhumdev.2008.06.010
Zilbovicius M, 2006, TRENDS NEUROSCI, V29, P359, DOI 10.1016/j.tins.2006.06.004
NR 42
TC 2
Z9 2
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI PARIS
PA 23 RUE LINOIS, 75724 PARIS, FRANCE
SN 0929-693X
J9 ARCH PEDIATRIE
JI Arch. Pediatr.
PD SEP
PY 2012
VL 19
IS 9
BP 970
EP 975
DI 10.1016/j.arcped.2012.06.007
PG 6
WC Pediatrics
SC Pediatrics
GA 002FD
UT WOS:000308516500013
PM 22877858
ER
PT J
AU Evans, CA
Nelson, LJ
Porter, CL
AF Evans, Cortney A.
Nelson, Larry J.
Porter, Christin L.
TI Making Sense of Their World: Sensory Reactivity and Novelty Awareness as
Aspects of Temperament and Correlates of Social Behaviours in Early
Childhood
SO INFANT AND CHILD DEVELOPMENT
LA English
DT Article
DE sensory reactivity; novelty awareness; temperament; sensory thresholds
ID YOUNG-CHILDREN; PROACTIVE AGGRESSION; EFFORTFUL CONTROL; SENSITIVITY;
PRESCHOOL; EMOTIONALITY; KNOWLEDGE; CONSTRUCT; AUTISM; MODEL
AB This study examines the early emergence of sensory reactivity and novelty awareness and their relations to children's behaviours with peers. A total of 260 parents (242 mothers, 18 fathers) and 10 teachers of 260 children (131 male, 129 female; M?=?63?months; SD?=?8.80; range?=?39-81) participated. Structural equation models indicate that sensory reactive children appear to be less social (i.e. prosocial and friendly), more likely to engage in solitary-active play behaviour, and more prone to utilize instrumental aggression in peer interactions. Children scoring high on novelty awareness tend to be more social (i.e. prosocial, friendly, and control impulses), better able to appropriately and punctually comply with tasks given by teacher, less likely to engage in a number of solitary play behaviours (i.e. solitary passive and solitary active), less likely to utilize instrumental or reactive aggressive strategies, and more likely to dodge negative peer interactions by avoiding bullies. Furthermore, the associations between sensory reactivity/novelty awareness and children's behaviours differ from those of other dimensions of temperament (i.e. activity level and emotionality). This suggests that novelty awareness and sensory reactivity uniquely contribute to our overall understanding of children's temperament and its correlates. Copyright (c) 2012 John Wiley & Sons, Ltd.
C1 [Evans, Cortney A.; Nelson, Larry J.; Porter, Christin L.] Brigham Young Univ, Sch Family Life, Provo, UT 84602 USA.
RP Evans, CA (reprint author), Brigham Young Univ, Sch Family Life, 2086 JFSB, Provo, UT 84602 USA.
EM cortney_evans@byu.edu
CR Aron EN, 1997, J PERS SOC PSYCHOL, V73, P345, DOI 10.1037/0022-3514.73.2.345
Aron EN, 1999, SER AFFECTIVE SCI, P251
Baranek GT, 2002, J AUTISM DEV DISORD, V32, P397, DOI 10.1023/A:1020541906063
Belsky J, 2009, PSYCHOL BULL, V135, P885, DOI 10.1037/a0017376
BUSS DM, 1980, CHILD DEV, V51, P401, DOI 10.2307/1129273
Calkins SD, 1999, SOC DEV, V8, P310, DOI 10.1111/1467-9507.00098
Calkins SD, 1996, CHILD DEV, V67, P523, DOI 10.1111/j.1467-8624.1996.tb01749.x
COPLAN RJ, 1994, CHILD DEV, V65, P129, DOI 10.1111/j.1467-8624.1994.tb00739.x
CRICK NR, 1995, CHILD DEV, V66, P710, DOI 10.1111/j.1467-8624.1995.tb00900.x
Crick NR, 1997, DEV PSYCHOL, V33, P579, DOI 10.1037/0012-1649.33.4.579
Crick NR, 1996, CHILD DEV, V67, P993, DOI 10.1111/j.1467-8624.1996.tb01778.x
DEARY IJ, 1994, AM J PSYCHOL, V107, P95, DOI 10.2307/1423292
Dunn W, 1997, INFANT YOUNG CHILD, V9, P23
Dunn W, 2007, INFANT YOUNG CHILD, V20, P84
Eisenberg N, 1998, SCHOOL PSYCHOL REV, V27, P506
Ellis BJ, 2005, DEV PSYCHOPATHOL, V17, P303, DOI 10.1017/S0954579405050157
Ermer J. A., 1996, AM J OCCUPATIONAL TH, V52, P283
Evans DE, 2008, PERS INDIV DIFFER, V44, P108, DOI 10.1016/j.paid.2007.07.016
Evans M. A., 2004, INT SOC STUD BEH DEV
Gere D. R., 2004, AM J OCCUPATIONAL TH, V63, P288
Hart C. H., 1996, TEACHER BEHAV UNPUB
Hubbard JA, 2010, J PERS, V78, P95, DOI 10.1111/j.1467-6494.2009.00610.x
Hughes C, 2000, J CHILD PSYCHOL PSYC, V41, P169, DOI 10.1017/S0021963099005193
Izard C, 2001, PSYCHOL SCI, V12, P18, DOI 10.1111/1467-9280.00304
Kagan J, 1997, CHILD DEV, V68, P139, DOI 10.1111/j.1467-8624.1997.tb01931.x
Nelson LJ, 2008, SOC DEV, V17, P812, DOI 10.1111/j.1467-9507.2008.00470.x
Olson SL, 2005, DEV PSYCHOPATHOL, V17, P25, DOI 10.1017/S0954579405050029
Rothbart MK, 2007, CHILD DEV PERSPECT, V1, P2, DOI 10.1111/j.1750-8606.2007.00002.x
Rothbart MK, 2001, CHILD DEV, V72, P1394, DOI 10.1111/1467-8624.00355
ROWE DC, 1977, J PERS ASSESS, V41, P150, DOI 10.1207/s15327752jpa4102_5
RUBIN KH, 1993, SOCIAL WITHDRAWAL, INHIBITION, AND SHYNESS IN CHILDHOOD, P3
Rubins K., 2002, BLACKWELL HDB CHILDH, P329
Smith-Donald R, 2007, EARLY CHILD RES Q, V22, P173, DOI 10.1016/j.ecresq.2007.01.002
Stifter CA, 1999, CHILD DEV, V70, P21, DOI 10.1111/1467-8624.00003
Thomas A., 1977, TEMPERAMENT DEV
Tomchek SD, 2007, AM J OCCUP THER, V61, P190
Vitiello B, 1997, J AM ACAD CHILD PSY, V36, P307, DOI 10.1097/00004583-199703000-00008
NR 37
TC 2
Z9 2
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1522-7227
J9 INFANT CHILD DEV
JI Infant Child Dev.
PD SEP-OCT
PY 2012
VL 21
IS 5
BP 503
EP 520
DI 10.1002/icd.1754
PG 18
WC Psychology, Developmental
SC Psychology
GA 999GX
UT WOS:000308298900005
ER
PT J
AU Stephens, BE
Bann, CM
Watson, VE
Sheinkopf, SJ
Peralta-Carcelen, M
Bodnar, A
Yolton, K
Goldstein, RF
Dusick, AM
Wilson-Costello, DE
Acarregui, MJ
Pappas, A
Adams-Chapman, I
McGowan, EC
Heyne, RJ
Hintz, SR
Ehrenkranz, RA
Fuller, J
Das, A
Higgins, RD
Vohr, BR
AF Stephens, Bonnie E.
Bann, Carla M.
Watson, Victoria E.
Sheinkopf, Stephen J.
Peralta-Carcelen, Myriam
Bodnar, Anna
Yolton, Kimberly
Goldstein, Ricki F.
Dusick, Anna M.
Wilson-Costello, Deanne E.
Acarregui, Michael J.
Pappas, Athina
Adams-Chapman, Ira
McGowan, Elisabeth C.
Heyne, Roy J.
Hintz, Susan R.
Ehrenkranz, Richard A.
Fuller, Janell
Das, Abhik
Higgins, Rosemary D.
Vohr, Betty R.
CA Eunice Kennedy Shriver Natl Inst C
TI Screening for Autism Spectrum Disorders in Extremely Preterm Infants
SO JOURNAL OF DEVELOPMENTAL AND BEHAVIORAL PEDIATRICS
LA English
DT Article
DE autism; prematurity; screening
ID BIRTH-WEIGHT; RISK-FACTORS; CHILDREN; OUTCOMES
AB Background: Extremely preterm(EP) infants screen positive for autism spectrum disorders (ASD) at high rates. However, it is not clear whether this is because of high rates of ASD in EPs or to high rates of false-positive screens for ASD in children with a high rate of underlying neurodevelopmental impairments. Combining a parent questionnaire designed to distinguish developmental delay from ASD with direct observation of infant behavior may more accurately screen for ASD in EPs. Objectives: To determine rates of positive screen for ASD at 18 to 22 months(m) in EPs using 3 screens; to determine factors associated with a positive screen. Methods: Five hundred fifty-four infants born <27 weeks were screened at 18 to 22 m using the Pervasive Developmental Disorders Screening test, second edition Stage 2, and the response to name and response to joint attention items from the Autism Diagnostic Observation Schedule. Infants with severe cerebral palsy, deafness, and blindness were excluded. Associations between positive screen and neonatal/ infant characteristics were determined. Results: Of 554 infants, 113 (20%) had >= 1 positive screen. 10% had a positive Pervasive Developmental Disorders Screening test, second edition, 6% response to name, 9% response to joint attention; in only 1 % all 3 screens were positive. Positive screen was associated with male gender, more hospital days, white race, lower maternal education, abnormal behavioral scores, and cognitive/ language delay. Conclusions: The use of 3 screens for ASD in EPs results in higher screen positive rates than use of 1 screen alone. Diagnostic confirmation is needed before true rates of ASD in EPs are known. (J Dev Behav Pediatr 33:535-541, 2012)
C1 [Stephens, Bonnie E.; Watson, Victoria E.; Vohr, Betty R.] Brown Univ, Women & Infants Hosp, Dept Pediat, Providence, RI 02905 USA.
[Bann, Carla M.] RTI Int, Stat & Epidemiol Unit, Res Triangle Pk, NC USA.
[Sheinkopf, Stephen J.] Brown Univ, Women & Infants Hosp, Dept Psychiat & Human Behav, Ctr Study Children Risk,Brown Alpert Med Sch, Providence, RI USA.
[Peralta-Carcelen, Myriam] Univ Alabama Birmingham, Div Neonatol, Birmingham, AL USA.
[Bodnar, Anna] Univ Utah, Sch Med, Dept Pediat, Div Neonatol, Salt Lake City, UT USA.
[Yolton, Kimberly] Univ Cincinnati, Dept Pediat, Cincinnati Childrens Hosp Med Ctr, Cincinnati, OH 45221 USA.
[Goldstein, Ricki F.] Duke Univ, Dept Pediat, Durham, NC 27706 USA.
[Dusick, Anna M.] Indiana Univ Sch Med, Dept Pediat, Indianapolis, IN USA.
[Wilson-Costello, Deanne E.] Case Western Reserve Univ, Rainbow Babies & Childrens Hosp, Dept Pediat, Cleveland, OH 44106 USA.
[Acarregui, Michael J.] Univ Iowa, Dept Pediat, Iowa City, IA 52242 USA.
[Pappas, Athina] Wayne State Univ, Dept Pediat, Detroit, MI 48202 USA.
[Adams-Chapman, Ira] Emory Univ, Sch Med, Dept Pediat, Atlanta, GA USA.
[Adams-Chapman, Ira] Childrens Healthcare Atlanta, Atlanta, GA USA.
[McGowan, Elisabeth C.] Floating Hosp Children, Tufts Med Ctr, Dept Pediat, Div Newborn Med, Boston, MA USA.
[Heyne, Roy J.] Univ Texas SW Med Ctr Dallas, Dept Pediat, Dallas, TX 75390 USA.
[Hintz, Susan R.] Stanford Univ, Sch Med, Dept Pediat, Palo Alto, CA 94304 USA.
[Ehrenkranz, Richard A.] Yale Univ, Sch Med, Dept Pediat, New Haven, CT 06510 USA.
[Fuller, Janell] Univ New Mexico, Hlth Sci Ctr, Albuquerque, NM 87131 USA.
[Das, Abhik] RTI Int, Stat & Epidemiol Unit, Rockville, MD USA.
[Higgins, Rosemary D.] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, NIH, Bethesda, MD USA.
RP Stephens, BE (reprint author), Brown Univ, Women & Infants Hosp, Dept Pediat, 101 Dudley St, Providence, RI 02905 USA.
EM bstephens@wihri.org
CR American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th
Bayley N, 2006, BAYLEY SCALES INFANT, V3rd
BELL MJ, 1978, ANN SURG, V187, P1, DOI 10.1097/00000658-197801000-00001
Briggs-Gowan MJ, 2004, J PEDIATR PSYCHOL, V29, P143, DOI 10.1093/jpepsy/jsh017
Bryson SE, 2003, CAN J PSYCHIAT, V48, P506
Costeloe K, 2000, PEDIATRICS, V106, P659, DOI 10.1542/peds.106.4.659
Dumont-Mathieu T, 2005, MENT RETARD DEV D R, V11, P253, DOI 10.1002/mrdd.20072
HACK M, 1991, PEDIATRICS, V87, P587
Johnson CP, 2007, PEDIATRICS, V120, P1183, DOI 10.1542/peds.2007-2361
Johnson S, 2010, J PEDIATR-US, V156, P525, DOI 10.1016/j.jpeds.2009.10.041
Kolevzon A, 2007, ARCH PEDIAT ADOL MED, V161, P326, DOI 10.1001/archpedi.161.4.326
Kuban KCK, 2009, J PEDIATR-US, V154, P535, DOI 10.1016/j.jpeds.2008.10.011
Limperopoulos C, 2008, PEDIATRICS, V121, P758, DOI 10.1542/peds.2007-2158
Lord C., 2001, AUTISM DIAGNOSTIC OB
McQuistin A, 2006, J AUTISM DEV DISORD, V36, P577, DOI 10.1007/s10803-006-0097-y
Nadig AS, 2007, ARCH PEDIAT ADOL MED, V161, P378, DOI 10.1001/archpedi.161.4.378
O'Shea TM, 2009, EARLY HUM DEV, V85, P719, DOI 10.1016/j.earlhumdev.2009.08.060
Palisano R, 1997, DEV MED CHILD NEUROL, V39, P214
PAPILE LA, 1978, J PEDIATR-US, V92, P529, DOI 10.1016/S0022-3476(78)80282-0
Schendel D, 2008, PEDIATRICS, V121, P1155, DOI 10.1542/peds.2007-1049
Siegel B., 2004, PERVASIVE DEV DISORD
Sullivan M, 2007, J AUTISM DEV DISORD, V37, P37, DOI 10.1007/s10803-006-0335-3
NR 22
TC 13
Z9 13
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0196-206X
J9 J DEV BEHAV PEDIATR
JI J. Dev. Behav. Pediatr.
PD SEP
PY 2012
VL 33
IS 7
BP 535
EP 541
DI 10.1097/DBP.0b013e31825fd0af
PG 7
WC Behavioral Sciences; Psychology, Developmental; Pediatrics
SC Behavioral Sciences; Psychology; Pediatrics
GA 004GH
UT WOS:000308668400002
PM 22926660
ER
PT J
AU Abdelmoity, AT
LePichon, JB
Nyp, SS
Soden, SE
Daniel, CA
Yu, SH
AF Abdelmoity, Ahmed T.
LePichon, Jean-Baptiste
Nyp, Sarah S.
Soden, Sarah E.
Daniel, Carol A.
Yu, Shihui
TI 15q11.2 Proximal Imbalances Associated With a Diverse Array of
Neuropsychiatric Disorders and Mild Dysmorphic Features
SO JOURNAL OF DEVELOPMENTAL AND BEHAVIORAL PEDIATRICS
LA English
DT Article
DE deletion; duplication; 15q11.2; neuropsychatric disorder; dysmorphic
feature
ID COMPARATIVE GENOMIC HYBRIDIZATION; HEREDITARY SPASTIC PARAPLEGIA;
GLOBUS-PALLIDUS DYSFUNCTION; PRADER-WILLI-SYNDROME; RECURRENT
MICRODELETIONS; SCHIZOPHRENIA; RISK; VARIANTS; DELETION; AUTISM
AB Deletion within the proximal region of chromosome 15q11.2 between breakpoints 1 and 2 (BP1-BP2) has been proposed to be a risk factor for intellectual disability, seizure, and schizophrenia. However, the clinical significance of its reciprocal duplication is not clearly defined yet. We evaluated 1654 consecutive pediatric patients with various neurological disorders by high-resolution microarray-based comparative genomic hybridization. We identified 21 patients carrying 15q11.2 BP1-BP2 deletion and 12 patients carrying 15q11.2 BP1-BP2 duplication in this cohort, which represent 1.27% (21/1,654) and 0.7% (12/1,654) of the patients analyzed, respectively. Approximately 87.5% of the patients carrying the deletion and 80% of the patients carrying the duplication have developmental delay or intellectual disability. Other recurrent clinical features in these patients include mild dysmorphic features, autistic spectrum disorders, and epilepsy. Our observations provide further evidence in favor of a strong association of 15q11.2 BP1-BP2 deletion with a variety of neuropsychiatric disorders. The diversity of clinical findings in these patients expands the phe-notypic spectrum of individuals carrying the deletion. In addition, possible etiological effects of 15q11.2 BP1-BP2 duplication in neuropsychiatric disorders are proposed.
C1 [Abdelmoity, Ahmed T.; LePichon, Jean-Baptiste; Nyp, Sarah S.; Soden, Sarah E.; Daniel, Carol A.; Yu, Shihui] Univ Missouri, Kansas City Sch Med, Kansas City, MO 64110 USA.
[Abdelmoity, Ahmed T.; LePichon, Jean-Baptiste] Childrens Mercy Hosp & Clin, Neurol Sect, Kansas City, MO USA.
[Nyp, Sarah S.; Soden, Sarah E.; Daniel, Carol A.] Childrens Mercy Hosp & Clin, Sect Dev & Behav Sci, Kansas City, MO USA.
[Yu, Shihui] Childrens Mercy Hosp & Clin, Dept Pathol, Kansas City, MO USA.
RP Yu, SH (reprint author), Seattle Childrens Hosp, Cytogenet Lab, 4800 Sand Point Way NE,POB 5371, Seattle, WA 98105 USA.
EM shihui.yu@seattlechildrens.org
CR Burbach JPH, 2009, TRENDS NEUROSCI, V32, P69, DOI 10.1016/j.tins.2008.11.002
Burnside R, 2011, HUM GENET, V130, P517, DOI 10.1007/s00439-011-0970-4
Butler MG, 2004, PEDIATRICS, V113, P565, DOI 10.1542/peds.113.3.565
Chai JH, 2003, AM J HUM GENET, V73, P898, DOI 10.1086/378816
de Kovel CGF, 2010, BRAIN, V133, P23, DOI 10.1093/brain/awp262
De Rubeis S, 2011, J NEURODEV DISORD, V3, P257, DOI 10.1007/s11689-011-9087-2
Doornbos M, 2009, EUR J MED GENET, V52, P108, DOI 10.1016/j.ejmg.2009.03.010
Francois C, 2004, BRAIN, V127, P2055, DOI 10.1093/brain/awh239
Grabli D, 2004, BRAIN, V127, P2039, DOI 10.1093/brain/awh220
Hartley SL, 2005, AM J MED GENET A, V136A, P140, DOI 10.1002/ajmg.a.30771
Helbig I, 2009, NAT GENET, V41, P160, DOI 10.1038/ng.292
Ingason A, 2011, AM J PSYCHIAT, V168, P408, DOI 10.1176/appi.ajp.2010.09111660
International Schizophrenia Consortium, 2008, CARBON NANOTUBES LON, V455, P237
Itsara A, 2009, AM J HUM GENET, V84, P148, DOI 10.1016/j.ajhg.2008.12.014
Kirov G, 2009, HUM MOL GENET, V18, P1497, DOI 10.1093/hmg/ddp043
Mefford HC, 2009, GENOME RES, V19, P1579, DOI 10.1101/gr.094987.109
Nagase T, 2001, DNA RES, V8, P179, DOI 10.1093/dnares/8.4.179
Nishimura Y, 2007, HUM MOL GENET, V16, P1682, DOI 10.1093/hmg/ddm116
Nowicki ST, 2007, J DEV BEHAV PEDIATR, V28, P133, DOI 10.1097/01.DBP.0000267563.18952.c9
Reed JA, 2005, NEUROGENETICS, V6, P79, DOI 10.1007/s10048-004-0209-9
Sahoo T, 2006, J MED GENET, V43, P512, DOI 10.1136/jmg.2005.036913
Scoles HA, 2011, MOL AUTISM, V2, DOI 10.1186/2040-2392-2-19
Shen YP, 2010, PEDIATRICS, V125, pE727, DOI 10.1542/peds.2009-1684
Stefansson H, 2009, NATURE, V460, P744, DOI 10.1038/nature08186
Stefansson H, 2008, NATURE, V455, P232, DOI 10.1038/nature07229
Stewart LR, 2011, BMC MED GENET, V12, DOI 10.1186/1471-2350-12-154
Tsang HTH, 2009, HUM MOL GENET, V18, P3805, DOI 10.1093/hmg/ddp324
Turner DJ, 2008, NAT GENET, V40, P90, DOI 10.1038/ng.2007.40
van der Zwaag B, 2010, AM J MED GENET B, V153B, P960, DOI 10.1002/ajmg.b.31055
Xiong Y, 2009, J CELL SCI, V122, P4218, DOI 10.1242/jcs.059196
Yu SH, 2009, GENET TEST MOL BIOMA, V13, P751, DOI 10.1089/gtmb.2009.0056
Yu SH, 2009, AM J CLIN PATHOL, V132, P349, DOI 10.1309/AJCP1BOUTWF6ERYS
Zody MC, 2006, NATURE, V440, P671, DOI 10.1038/nature04601
NR 33
TC 12
Z9 12
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0196-206X
J9 J DEV BEHAV PEDIATR
JI J. Dev. Behav. Pediatr.
PD SEP
PY 2012
VL 33
IS 7
BP 570
EP 576
DI 10.1097/DBP.0b013e31826052ae
PG 7
WC Behavioral Sciences; Psychology, Developmental; Pediatrics
SC Behavioral Sciences; Psychology; Pediatrics
GA 004GH
UT WOS:000308668400007
PM 22922608
ER
PT J
AU Poon, JK
AF Poon, Jennifer K.
TI A Picture's Worth PECS and Other Visual Communication Strategies in
Autism, 2nd Edition
SO JOURNAL OF DEVELOPMENTAL AND BEHAVIORAL PEDIATRICS
LA English
DT Book Review
C1 [Poon, Jennifer K.] Med Univ S Carolina, Charleston, SC 29425 USA.
RP Poon, JK (reprint author), Med Univ S Carolina, Charleston, SC 29425 USA.
CR Frost L., 2011, PICTURES WORTH PECS
NR 1
TC 0
Z9 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0196-206X
J9 J DEV BEHAV PEDIATR
JI J. Dev. Behav. Pediatr.
PD SEP
PY 2012
VL 33
IS 7
BP 585
EP 585
DI 10.1097/DBP.0b013e31826c9eda
PG 1
WC Behavioral Sciences; Psychology, Developmental; Pediatrics
SC Behavioral Sciences; Psychology; Pediatrics
GA 004GH
UT WOS:000308668400009
ER
PT J
AU Codagnone, MG
Podesta, MF
Uccelli, NA
Reines, A
AF Codagnone, M. G.
Podesta, M. F.
Uccelli, N. A.
Reines, A.
TI Altered hippocampal neuronal organization and NCAM expression in an
animal model of autism
SO JOURNAL OF NEUROCHEMISTRY
LA English
DT Meeting Abstract
CT 5th Special Conference of the International-Society-for-Neurochemistry
on Synapses and Dendritic Spines in Health and Disease
CY SEP 12-15, 2012
CL Buenos Aires, ARGENTINA
SP Int Soc Neurochem
C1 [Codagnone, M. G.; Podesta, M. F.; Uccelli, N. A.; Reines, A.] UBA, Inst Invest Farmacol ININFA CONICET UBA, Buenos Aires, DF, Argentina.
[Codagnone, M. G.; Podesta, M. F.; Reines, A.] UBA, Fac Farm & Bioquim, Catedra Farmacol, Buenos Aires, DF, Argentina.
NR 0
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0022-3042
J9 J NEUROCHEM
JI J. Neurochem.
PD SEP
PY 2012
VL 122
SU 1
SI SI
BP 14
EP 14
PG 1
WC Biochemistry & Molecular Biology; Neurosciences
SC Biochemistry & Molecular Biology; Neurosciences & Neurology
GA 003BI
UT WOS:000308582800042
ER
PT J
AU Campolongo, M
Kazlauskas, N
Lucchina, L
Depino, A
AF Campolongo, M.
Kazlauskas, N.
Lucchina, L.
Depino, A.
TI Social rescue of autism-related symptoms in a mouse model
SO JOURNAL OF NEUROCHEMISTRY
LA English
DT Meeting Abstract
CT 5th Special Conference of the International-Society-for-Neurochemistry
on Synapses and Dendritic Spines in Health and Disease
CY SEP 12-15, 2012
CL Buenos Aires, ARGENTINA
SP Int Soc Neurochem
C1 Univ Buenos Aires, Dept Physiol Mol & Cellular Biol, FCEyN, Buenos Aires, DF, Argentina.
CONICET UBA, Inst Physiol Mol Biol & Neurosci, Buenos Aires, DF, Argentina.
NR 0
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0022-3042
J9 J NEUROCHEM
JI J. Neurochem.
PD SEP
PY 2012
VL 122
SU 1
SI SI
BP 33
EP 33
PG 1
WC Biochemistry & Molecular Biology; Neurosciences
SC Biochemistry & Molecular Biology; Neurosciences & Neurology
GA 003BI
UT WOS:000308582800095
ER
PT J
AU Ricciardi, S
Ungaro, F
Hambrock, M
Rademacher, N
Stefanelli, G
Brambilla, D
Sessa, A
Magagnotti, C
Bachi, A
Giarda, E
Verpelli, C
Kilstrup-Nielsen, C
Sala, C
Kalscheuer, VM
Broccoli, V
AF Ricciardi, Sara
Ungaro, Federica
Hambrock, Melanie
Rademacher, Nils
Stefanelli, Gilda
Brambilla, Dario
Sessa, Alessandro
Magagnotti, Cinzia
Bachi, Angela
Giarda, Elisa
Verpelli, Chiara
Kilstrup-Nielsen, Charlotte
Sala, Carlo
Kalscheuer, Vera M.
Broccoli, Vania
TI CDKL5 ensures excitatory synapse stability by reinforcing NGL-1-PSD95
interaction in the postsynaptic compartment and is impaired in patient
iPSC-derived neurons
SO NATURE CELL BIOLOGY
LA English
DT Article
ID RETT-SYNDROME; INFANTILE SPASMS; MENTAL-RETARDATION; EPILEPTIC
ENCEPHALOPATHY; INTERSTITIAL DELETION; ADHESION MOLECULES; MUTATIONS;
GENE; PROTEIN; PHOSPHORYLATION
AB Mutations of the cyclin-dependent kinase-like 5 (CDKL5) and netrin-G1 (NTNG1) genes cause a severe neurodevelopmental disorder with clinical features that are closely related to Rett syndrome, including intellectual disability, early-onset intractable epilepsy and autism.We report here that CDKL5 is localized at excitatory synapses and contributes to correct dendritic spine structure and synapse activity. To exert this role, CDKL5 binds and phosphorylates the cell adhesion molecule NGL-1. This phosphorylation event ensures a stable association between NGL-1 and PSD95. Accordingly, phospho-mutant NGL-1 is unable to induce synaptic contacts whereas its phospho-mimetic form binds PSD95 more efficiently and partially rescues the CDKL5-specific spine defects. Interestingly, similarly to rodent neurons, iPSC-derived neurons from patients with CDKL5 mutations exhibit aberrant dendritic spines, thus suggesting a common function of CDKL5 in mice and humans.
C1 [Hambrock, Melanie; Rademacher, Nils; Kalscheuer, Vera M.] Max Planck Inst Mol Genet, Dept Human Mol Genet, D-14195 Berlin, Germany.
[Ricciardi, Sara; Ungaro, Federica; Stefanelli, Gilda; Sessa, Alessandro; Broccoli, Vania] Ist Sci San Raffaele, Stem Cell & Neurogenesis Unit, Div Neurosci, I-20132 Milan, Italy.
[Brambilla, Dario] Univ Milan, Sch Med, Dept Human Physiol, I-20133 Milan, Italy.
[Magagnotti, Cinzia; Bachi, Angela] Ist Sci San Raffaele, Div Genet & Cell Biol, I-20132 Milan, Italy.
[Giarda, Elisa; Kilstrup-Nielsen, Charlotte] Univ Insubria, Dept Struct & Funct Biol, Lab Genet & Epigenet Control Gene Express, I-21052 Busto Arsizio, VA, Italy.
[Verpelli, Chiara; Sala, Carlo] Consiglio Nazl Ric Neurosci Inst, I-20129 Milan, Italy.
RP Kalscheuer, VM (reprint author), Max Planck Inst Mol Genet, Dept Human Mol Genet, Ihnestr 73, D-14195 Berlin, Germany.
EM kalscheu@molgen.mpg.de; broccoli.vania@hsr.it
RI Kilstrup-Nielsen, Charlotte/A-6348-2014; Sala, Carlo/A-2493-2009
OI Sala, Carlo/0000-0003-0662-9523
FU Telethon Foundation; Ministry of Health; IIT-SEED project; EuroRETT
network; EU-FP7 project GENCODYS [241995]
FX We gratefully acknowledge T. Bienvenu for providing primary fibroblasts
from CDKL5 patients, H. Van Esch and H. Archer for providing DNA samples
from patients, S. Freier, A. Walther, A. Grimme, U. Fischer and B. Moser
for their excellent technical assistance, and L. Musante for helpful
discussions. L. Pecciarini is acknowledged for karyotype analysis of the
iPSC lines. This study was supported by the Telethon Foundation,
Ministry of Health, IIT-SEED project, EuroRETT network to V.B. and the
EU-FP7 project GENCODYS (241995) to V.M.K.
CR Amir RE, 1999, NAT GENET, V23, P185
Archer HL, 2006, J MED GENET, V43, P729, DOI 10.1136/jmg.2006.041467
Bahi-Buisson N, 2008, BRAIN, V131, P2647, DOI 10.1093/brain/awn197
Bayes A, 2011, NAT NEUROSCI, V14, P19, DOI 10.1038/nn.2719
Bertani I, 2006, J BIOL CHEM, V281, P32048, DOI 10.1074/jbc.M606325200
Bienvenu T, 2006, NAT REV GENET, V7, P415, DOI 10.1038/nrg1878
Borg I, 2005, EUR J HUM GENET, V13, P921, DOI 10.1038/sj.ejhg.5201429
Chahrour M, 2007, NEURON, V56, P422, DOI 10.1016/j.neuron.2007.10.001
Chen QA, 2010, J NEUROSCI, V30, P12777, DOI 10.1523/JNEUROSCI.1102-10.2010
Chung HJ, 2004, J NEUROSCI, V24, P10248, DOI 10.1523/JNEUROSCI.0546-04.2004
Cohen NA, 1996, NEURON, V17, P759, DOI 10.1016/S0896-6273(00)80207-X
Colleoni S, 2010, EXP CELL RES, V316, P1148, DOI 10.1016/j.yexcr.2010.02.013
Cordova-Fletes C., 2010, CLIN GENET, V77, P92
Essmann CL, 2008, NAT NEUROSCI, V11, P1035, DOI 10.1038/nn.2171
Francke U, 2006, NAT CLIN PRACT NEURO, V2, P212, DOI 10.1038/ncpneuro0148
Han K, 2008, PROG NEUROBIOL, V84, P263, DOI 10.1016/j.pneurobio.2007.10.011
Hering H, 2001, NAT REV NEUROSCI, V2, P880, DOI 10.1038/35104061
Huttlin EL, 2010, CELL, V143, P1174, DOI 10.1016/j.cell.2010.12.001
Kalscheuer VM, 2003, AM J HUM GENET, V72, P1401, DOI 10.1086/375538
Kennedy MB, 2005, NAT REV NEUROSCI, V6, P423, DOI 10.1038/nrn1685
Kim EE, 2009, CURR MED IMAGING REV, V5, P1
Kim Kwang Young, 2011, Algae, V26, P1, DOI 10.4490/algae.2011.26.1.001
Kim S, 2006, NAT NEUROSCI, V9, P1294, DOI 10.1038/nn1763
Liang JS, 2011, EPILEPSIA, V52, P1835, DOI 10.1111/j.1528-1167.2011.03174.x
Lin JC, 2003, NAT NEUROSCI, V6, P1270, DOI 10.1038/nn1148
Marchetto MCN, 2010, CELL, V143, P527, DOI 10.1016/j.cell.2010.10.016
Mari F, 2005, HUM MOL GENET, V14, P1935, DOI 10.1093/hmg/ddi198
Mei D, 2010, EPILEPSIA, V51, P647, DOI 10.1111/j.1528-1167.2009.02308.x
Migaud M, 1998, NATURE, V396, P433
Montini E, 1998, GENOMICS, V51, P427, DOI 10.1006/geno.1998.5391
Ohtsuki T, 2008, NEUROSCI LETT, V435, P194, DOI 10.1016/j.neulet.2008.02.053
O'Roak BJ, 2012, NATURE, V485, P246, DOI 10.1038/nature10989
Rademacher N, 2011, NEUROGENETICS, V12, P165, DOI 10.1007/s10048-011-0277-6
Ricciardi S, 2009, HUM MOL GENET, V18, P4590, DOI 10.1093/hmg/ddp426
Rosas-Vargas H, 2008, J MED GENET, V45, P172, DOI 10.1136/jmg.2007.053504
Rusconi L, 2011, J BIOL CHEM, V286, P36550, DOI 10.1074/jbc.M111.235630
Rusconi L, 2008, J BIOL CHEM, V283, P30101, DOI 10.1074/jbc.M804613200
Scala E, 2005, J MED GENET, V42, P103, DOI 10.1136/jmg.2004.026237
Tao J, 2004, AM J HUM GENET, V75, P1149, DOI 10.1086/426460
Tchieu J, 2010, CELL STEM CELL, V7, P329, DOI 10.1016/j.stem.2010.06.024
Van Esch H, 2007, AM J MED GENET A, V143A, P364, DOI 10.1002/ajmg.a.31572
van Kuilenburg ABP, 2009, HUM GENET, V125, P581, DOI 10.1007/s00439-009-0653-6
Weaving LS, 2004, AM J HUM GENET, V75, P1079, DOI 10.1086/426462
Woo J, 2009, MOL CELL NEUROSCI, V42, P1, DOI 10.1016/j.mcn.2009.05.008
Woo J, 2009, NAT NEUROSCI, V12, P428, DOI 10.1038/nn.2279
NR 45
TC 38
Z9 39
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1465-7392
J9 NAT CELL BIOL
JI Nat. Cell Biol.
PD SEP
PY 2012
VL 14
IS 9
BP 911
EP +
DI 10.1038/ncb2566
PG 24
WC Cell Biology
SC Cell Biology
GA 004GJ
UT WOS:000308668600007
PM 22922712
ER
PT J
AU Foo, JN
Liu, JJ
Tan, EK
AF Foo, Jia-Nee
Liu, Jian-Jun
Tan, Eng-King
TI Whole-genome and whole-exome sequencing in neurological diseases
SO NATURE REVIEWS NEUROLOGY
LA English
DT Review
ID DE-NOVO MUTATIONS; AUTISM SPECTRUM DISORDERS; PARKINSONS-DISEASE; WIDE
ASSOCIATION; COMMON VARIANTS; PERSONAL GENOME; RARE VARIANTS; GENE;
COMPLEX; TECHNOLOGY
AB Genetic risk factors that underlie many rare and common neurological disorders remain poorly understood because of the multifactorial and heterogeneous nature of these complex traits. With the decreasing cost of massively parallel sequencing technologies, whole-genome and whole-exome sequencing will soon allow the characterization of the full spectrum of sequence and structural variants present in each individual. Methods are being developed to parse the huge amount of genomic data and to sift out which variants are associated with diseases. Numerous challenges are inherent in the identification of rare and common variants that have a role in complex neurological diseases, and tools are being developed to overcome these challenges. Given that genomic data will soon be the main driver towards the goal of personalized medicine, future developments in the production and interpretation of data, as well as in ethics and counselling, will be needed for whole-genome and whole-exome sequencing to be used as informative tools in a clinical setting.
C1 [Tan, Eng-King] Duke Natl Univ Singapore, Grad Sch Med, Singapore Gen Hosp, Dept Neurol,Natl Neurosci Inst, Singapore 169108, Singapore.
[Foo, Jia-Nee; Liu, Jian-Jun] ASTAR, Genome Inst Singapore, Singapore 138672, Singapore.
RP Tan, EK (reprint author), Duke Natl Univ Singapore, Grad Sch Med, Singapore Gen Hosp, Dept Neurol,Natl Neurosci Inst, Block 1,Level 3,Outram Rd, Singapore 169108, Singapore.
EM tan.eng.king@sgh.com.sg
RI Foo, Jia Nee/D-6069-2014
OI Foo, Jia Nee/0000-0001-9899-2308
CR Adzhubei IA, 2010, NAT METHODS, V7, P248, DOI 10.1038/nmeth0410-248
[Anonymous], 2011, VAR AN AN SEARCH TOO
[Anonymous], 2007, MRNA SNP BROWS V1 0
Bansal V, 2010, NAT REV GENET, V11, P773, DOI 10.1038/nrg2867
Bentley DR, 2008, NATURE, V456, P53, DOI 10.1038/nature07517
Bilguvar K, 2010, NATURE, V467, P207, DOI 10.1038/nature09327
Bras J, 2012, HUM MOL GENET, V21, P2646, DOI 10.1093/hmg/dds089
Calvo SE, 2012, SCI TRANSL MED, V4, DOI 10.1126/scitranslmed.3003310
Cassa CA, 2011, GENOME RES, V22, P421
Chartier-Harlin MC, 2011, AM J HUM GENET, V89, P398, DOI 10.1016/j.ajhg.2011.08.009
Choi M, 2009, P NATL ACAD SCI USA, V106, P19096, DOI 10.1073/pnas.0910672106
Clark M. J., 2012, NAT BIOTECHNOL, V29, P908
CORDER EH, 1993, SCIENCE, V261, P921, DOI 10.1126/science.8346443
DePristo MA, 2011, NAT GENET, V43, P491, DOI 10.1038/ng.806
Dixon AL, 2007, NAT GENET, V39, P1202, DOI 10.1038/ng2109
Do CB, 2011, PLOS GENET, V7, DOI 10.1371/journal.pgen.1002141
ENCODE Project Consortium, 2004, LOGIC CIRCUITS CARBO, V306, P636
Erdmann J, 2011, CHEM BIOL, V18, P1513, DOI 10.1016/j.chembiol.2011.12.006
Fabsitz RR, 2010, CIRC-CARDIOVASC GENE, V3, P574, DOI 10.1161/CIRCGENETICS.110.958827
Genomes Project Consortium, 2010, CARBON NANOTUBES LON, V467, P1061
Girard SL, 2011, NAT GENET, V43, P860, DOI 10.1038/ng.886
Gonzalez-Perez A, 2011, AM J HUM GENET, V88, P440, DOI 10.1016/j.ajhg.2011.03.004
Guerreiro R. J., 2011, NEUROBIOL AGING, V33
Hayden EC, 2012, NATURE, V482, P288, DOI 10.1038/482288a
Hong KW, 2010, BMB REP, V43, P643, DOI 10.5483/BMBRep.2010.43.10.643
Johansson ACV, 2012, METHODS MOL BIOL, V838, P343, DOI 10.1007/978-1-61779-507-7_17
Johnson J. O., 2011, NEURON, V68, P857
Kasowski M, 2010, SCIENCE, V328, P232, DOI 10.1126/science.1183621
Kiezun A, 2012, NAT GENET, V44, P623, DOI 10.1038/ng.2303
Klassen T, 2011, CELL, V145, P1036, DOI 10.1016/j.cell.2011.05.025
Kumari U, 2009, FEBS J, V276, P6455, DOI 10.1111/j.1742-4658.2009.07344.x
Lander ES, 2001, NATURE, V409, P860, DOI 10.1038/35057062
Lee H, 2012, AM J HUM GENET, V90, P746, DOI 10.1016/j.ajhg.2012.03.004
Levy Samuel, 2007, PLoS Biol, V5, pe254, DOI 10.1371/journal.pbio.0050254
Lupski JR, 2010, NEW ENGL J MED, V362, P1181, DOI 10.1056/NEJMoa0908094
Lupski JR, 2011, CELL, V147, P32, DOI 10.1016/j.cell.2011.09.008
Lyon GJ, 2012, NATURE, V482, P300, DOI 10.1038/482300a
MacArthur DG, 2012, SCIENCE, V335, P823, DOI 10.1126/science.1215040
Mamanova L, 2010, NAT METHODS, V7, P111, DOI 10.1038/nmeth.1419
Mardis ER, 2011, NATURE, V470, P198, DOI 10.1038/nature09796
Mathieson I, 2012, NAT GENET, V44, P243, DOI 10.1038/ng.1074
Metzker ML, 2010, NAT REV GENET, V11, P31, DOI 10.1038/nrg2626
Montenegro G, 2011, ANN NEUROL, V69, P464, DOI 10.1002/ana.22235
Montgomery SB, 2011, PLOS GENET, V7, DOI 10.1371/journal.pgen.1002144
Nalls MA, 2011, LANCET, V377, P641, DOI 10.1016/S0140-6736(10)62345-8
National Human Genome Research Institute, 2012, DNA SEQ COSTS
Neale BM, 2012, NATURE, V485, P242, DOI 10.1038/nature11011
Nelson M. R., LOGIC CIRCUITS CARBO
Ng PC, 2003, NUCLEIC ACIDS RES, V31, P3812, DOI 10.1093/nar/gkg509
Ng PC, 2008, PLOS GENET, V4, DOI 10.1371/journal.pgen.1000160
Ng SB, 2009, NATURE, V461, P272, DOI 10.1038/nature08250
O'Roak BJ, 2012, NATURE, V485, P246, DOI 10.1038/nature10989
O'Roak BJ, 2011, NAT GENET, V43, P585, DOI 10.1038/ng.835
Pareek CS, 2011, J APPL GENET, V52, P413, DOI 10.1007/s13353-011-0057-x
Park PJ, 2009, NAT REV GENET, V10, P669, DOI 10.1038/nrg2641
Phimister EG, 2012, NEW ENGL J MED, V366, P757, DOI 10.1056/NEJMe1200749
Pierce BL, 2010, LANCET, V376, P869, DOI 10.1016/S0140-6736(10)61404-3
Ramagopalan SV, 2011, ANN NEUROL, V70, P881, DOI 10.1002/ana.22678
Roach JC, 2010, SCIENCE, V328, P636, DOI 10.1126/science.1186802
Sanders SJ, 2012, NATURE, V485, P237, DOI 10.1038/nature10945
Satake W, 2009, NAT GENET, V41, P1303, DOI 10.1038/ng.485
Schuierer S, 2010, BIOINFORMATICS, V26, P1922, DOI 10.1093/bioinformatics/btq307
Schwarz JM, 2010, NAT METHODS, V7, P575, DOI 10.1038/nmeth0810-575
Simon-Sanchez J, 2009, NAT GENET, V41, P1308, DOI 10.1038/ng.487
Tchernitchko D, 2004, CLIN CHEM, V50, P1974, DOI 10.1373/clinchem.2004.036053
Tennessen J. A., LOGIC CIRCUITS CARBO
Thomas-Chollier M, 2011, NUCLEIC ACIDS RES, V39, pW86, DOI 10.1093/nar/gkr377
Tucci A, 2012, NEUROSCI LETT, V518, P19, DOI 10.1016/j.neulet.2012.04.033
Venter JC, 2001, SCIENCE, V291, P1304, DOI 10.1126/science.1058040
Vilarino-Guell C, 2011, AM J HUM GENET, V89, P162, DOI 10.1016/j.ajhg.2011.06.001
Visscher PM, 2012, AM J HUM GENET, V90, P7, DOI 10.1016/j.ajhg.2011.11.029
Walker R. H., 2011, MOVEMENT DISORD, V27, P539
Wan JJ, 2012, NAT GENET, V44, P704, DOI 10.1038/ng.2254
Wang J, 2011, MICRO NANO LETT, V6, P133, DOI 10.1049/mnl.2010.0209
Wang Jun-Ling, 2011, Brain, V134, P3493, DOI 10.1093/brain/awr289
Weedon MN, 2011, AM J HUM GENET, V89, P308, DOI 10.1016/j.ajhg.2011.07.002
Wheeler DA, 2008, NATURE, V452, P872, DOI 10.1038/nature06884
Yandell M, 2011, GENOME RES, V21, P1529, DOI 10.1101/gr.123158.111
Zimprich A, 2011, AM J HUM GENET, V89, P168, DOI 10.1016/j.ajhg.2011.06.008
NR 79
TC 26
Z9 26
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 1759-4758
J9 NAT REV NEUROL
JI Nat. Rev. Neurol.
PD SEP
PY 2012
VL 8
IS 9
BP 508
EP 517
DI 10.1038/nrneurol.2012.148
PG 10
WC Clinical Neurology
SC Neurosciences & Neurology
GA 004GA
UT WOS:000308667700008
PM 22847385
ER
PT J
AU Dethier, M
Blairy, S
AF Dethier, Marie
Blairy, Sylvie
TI Capacity for Cognitive and Emotional Empathy in Alcohol-Dependent
Patients
SO PSYCHOLOGY OF ADDICTIVE BEHAVIORS
LA English
DT Article
DE alcohol-dependence; alcoholism typology; empathy; emotional facial
expressions; social relationship satisfaction
ID FACIAL EXPRESSION RECOGNITION; INTIMATE PARTNER VIOLENCE;
HIGH-FUNCTIONING AUTISM; TRAUMATIC BRAIN-INJURY; LONG-TERM ABSTINENCE;
INTERPERSONAL PROBLEMS; ANTISOCIAL PERSONALITY; MARITAL ADJUSTMENT;
GENDER-DIFFERENCES; ASPERGER-SYNDROME
AB This study assessed two previously unexplored facets of empathy in alcohol-dependent patients (ADS) divided into two groups according to Cloninger's alcoholism typology: the attribution of intentions according to emotional facial expressions (EFEs) and emotional contagion in reaction to EFEs. Twenty-three male Type-I ADs, 21 male Type-II ADs, and 24 male control participants were compared in two computerized tasks. First, participants rated the extent to which an adjective descriptive of personality weighted on interpersonal dimensions (of rejection, aggressiveness, dominance, and affiliation) corresponded with a video of a neutral EFE that changed to an intense EFE. Second, participants evaluated their own emotional states after watching a series of videos that depicted EFEs while their own face was being filmed. The results showed that Type-I ADs attributed more rejection intentions and fewer affiliation intentions to EFEs compared with controls; however, depression might better explain this biased attribution. Furthermore, AD subtypes showed a different pattern of intention attribution according to the emotions that were portrayed and the sex of the stimulus. In addition, angry EFE mimicry was stronger in Type-II ADs than other participants. Finally, ADs expressed fewer positive emotions and more negative emotions than controls when watching EFEs. These findings emphasize the importance of differentiating alcoholism subtypes and contribute to the understanding of AD interpersonal behaviors.
C1 [Dethier, Marie; Blairy, Sylvie] Univ Liege, Dept Psychol Cognit & Behav, Unit Cognit & Behav Clin Psychol, B-4000 Liege, Belgium.
RP Dethier, M (reprint author), Univ Liege, Dept Psychol Cognit & Behav, Unit Cognit & Behav Clin Psychol, Blvd Rectorat 3,B33, B-4000 Liege, Belgium.
EM marie.dethier@ulg.ac.be
CR Baron-Cohen S, 2004, J AUTISM DEV DISORD, V34, P163, DOI 10.1023/B:JADD.0000022607.19833.00
Bartek J K, 1999, Nurs Diagn, V10, P158
Beck A. T., 1996, BECK DEPRESSION INVE
Benton A.L., 1983, FACIAL RECOGNITION S
Bjork JM, 2004, ALCOHOL, V34, P133, DOI 10.1016/j.alcohol.2004.06.012
Blairy S, 1999, J NONVERBAL BEHAV, V23, P5, DOI 10.1023/A:1021370825283
Bornhofen C, 2008, NEUROPSYCHOL REHABIL, V18, P22, DOI 10.1080/09602010601061213
Bornhofen C, 2008, J INT NEUROPSYCH SOC, V14, P511, DOI 10.1017/S1355617708080703
Brozgold A Z, 1998, Appl Neuropsychol, V5, P15, DOI 10.1207/s15324826an0501_2
CACIOPPO JT, 1986, J PERS SOC PSYCHOL, V50, P260, DOI 10.1037//0022-3514.50.2.260
Caetano R, 2008, J FAM VIOLENCE, V23, P37, DOI 10.1007/s10896-007-9127-6
Cloninger CR, 1996, ALCOHOL HEALTH RES W, V20, P18
CLONINGER CR, 1981, ARCH GEN PSYCHIAT, V38, P861
CLONINGER CR, 1987, SCIENCE, V236, P410, DOI 10.1126/science.2882604
Combs DR, 2007, SCHIZOPHR RES, V91, P112, DOI 10.1016/j.schres.2006.12.010
Darwin C., 1872, EXPRESSION EMOTIONS, DOI [10.1037/10001-000, DOI 10.1037/10001-000]
Davis M. H., 1994, EMPATHY SOCIAL PSYCH
Dethier M., 2010, REV FRANCOPHONE CLIN, V15, P1
Dimberg U, 2000, PSYCHOL SCI, V11, P86, DOI 10.1111/1467-9280.00221
Douilliez C., 2008, REV FRANCOPHONE CLIN, V13, P1
Driessen M, 1998, ALCOHOL CLIN EXP RES, V22, P77, DOI 10.1097/00000374-199802000-00009
DUBERSTEIN PR, 1993, J NERV MENT DIS, V181, P80, DOI 10.1097/00005053-199302000-00002
Epstein EE, 1997, ALCOHOL CLIN EXP RES, V21, P547
ERIKSEN L, 1986, ADDICT BEHAV, V11, P309, DOI 10.1016/0306-4603(86)90058-4
EVANS CM, 1980, BRIT J ALCOHOL ALCOH, V15, P104
Fals-Stewart W, 2005, J CONSULT CLIN PSYCH, V73, P239, DOI 10.1037/0022-006X.73.2.239
Feldman R. S., 1991, FUNDAMENTALS NONVERB, P329
Floyd FJ, 2006, J ABNORM PSYCHOL, V115, P121, DOI 10.1037/0021-843X.115.1.121
Foisy M. L., 2005, J STUD ALCOHOL, V66, P663
Foisy ML, 2007, ALCOHOL CLIN EXP RES, V31, P404, DOI 10.1111/j.1530-0277.2006.00321.x
Fridlund A. J, 1997, PSYCHOL FACIAL EXPRE, V112, P103, DOI [10.1111/j.1439-0310.2006.01205.x, DOI 10.1111/J.1439-0310.2006.01205.X]
Fridlund A. J., 1994, HUMAN FACIAL EXPRESS
Frigerio E, 2002, PSYCHIAT RES, V113, P161, DOI 10.1016/S0165-1781(02)00244-5
Frommann N, 2003, PSYCHIAT RES, V117, P281, DOI 10.1016/S0165-1781(03)00039-8
Gendre F., 2002, PSYCHOL PSYCHOMETRIE, V23, P101
Gendre F., 2007, PRAT PSYCHOL, V13, P255, DOI [10.1016/j.prps.2007.01.004, DOI 10.1016/J.PRPS.2007.01.004]
Gilman SE, 2001, DRUG ALCOHOL DEPEN, V63, P277, DOI 10.1016/S0376-8716(00)00216-7
Glick P, 1997, PERS SOC PSYCHOL B, V23, P1323, DOI 10.1177/01461672972312009
Golan O, 2006, DEV PSYCHOPATHOL, V18, P591, DOI 10.1017/S0954579406060305
Halberstadt AG, 2011, J NONVERBAL BEHAV, V35, P35, DOI 10.1007/s10919-010-0099-5
Hale WW, 1998, PSYCHIAT RES, V80, P265, DOI 10.1016/S0165-1781(98)00070-5
Hallman J, 1996, J STUD ALCOHOL, V57, P155
Hatfield E., 1992, EMOTION SOCIAL BEHAV, V14, P151
Hess U, 2000, J NONVERBAL BEHAV, V24, P265, DOI 10.1023/A:1006623213355
Hess U, 2005, COGNITION EMOTION, V19, P515, DOI 10.1080/02699930441000364
Hess U, 2001, INT J PSYCHOPHYSIOL, V40, P129, DOI 10.1016/S0167-8760(00)00161-6
HOROWITZ LM, 1988, J CONSULT CLIN PSYCH, V56, P885, DOI 10.1037//0022-006X.56.6.885
Ichiyama MA, 1996, J CONSULT CLIN PSYCH, V64, P1245, DOI 10.1037/0022-006X.64.6.1245
Joormann J, 2006, J ABNORM PSYCHOL, V115, P705, DOI 10.1037/0021-843X.115.4.705
Karno MP, 2004, J STUD ALCOHOL, V65, P501
Knutson B, 1996, J NONVERBAL BEHAV, V20, P165, DOI 10.1007/BF02281954
Kornreich C, 2003, PSYCHIAT RES, V119, P251, DOI 10.1016/S0165-1781(03)00130-6
Kornreich C, 2001, PSYCHIAT RES, V102, P235, DOI 10.1016/S0165-1781(01)00261-X
Kornreich C, 2002, ALCOHOL ALCOHOLISM, V37, P394, DOI 10.1093/alcalc/37.4.394
Kornreich C, 2001, J STUD ALCOHOL, V62, P533
Lipps T., 1907, PSYCHOL UNTERSUCHUNG, V1, P694
Lynskey MT, 1998, DRUG ALCOHOL DEPEN, V52, P201, DOI 10.1016/S0376-8716(98)00095-7
MANDAL MK, 1985, PERCEPT MOTOR SKILL, V61, P13
Marlatt GA, 1996, ADDICTION, V91, pS37, DOI 10.1111/j.1360-0443.1996.tb02326.x
Marshal Michael P, 2003, Clin Psychol Rev, V23, P959, DOI 10.1016/j.cpr.2003.09.002
Martinotti G, 2009, AM J ADDICTION, V18, P157, DOI 10.1080/10550490802544391
Matsumoto D., 1988, JAPANESE CAUCASIAN F
Matyassy A, 2006, ALCOHOL ALCOHOLISM, V41, P512, DOI 10.1093/alcalc/agl045
Maurage P, 2009, ALCOHOL ALCOHOLISM, V44, P476, DOI 10.1093/alcalc/agp037
McDonald S, 2008, ARCH PHYS MED REHAB, V89, P1648, DOI 10.1016/j.apmr.2008.02.029
McIntosh D.N., 2006, POLISH PSYCHOL B, V37, P31
McNally AM, 2003, ADDICT BEHAV, V28, P1115, DOI 10.1016/S0306-4603(02)00224-1
Miller W. R., 1998, TREATING ADDICTIVE B, P203
Modestin J, 1997, EUR PSYCHIAT, V12, P335, DOI 10.1016/S0924-9338(97)80002-8
Mueller SE, 2009, INT J ENV RES PUB HE, V6, P3010, DOI 10.3390/ijerph6123010
Mueser K. T., 1998, HDB SOCIAL FUNCTIONI, P181
Murphy CM, 2001, J CONSULT CLIN PSYCH, V69, P528, DOI 10.1037//0022-006X.69.3.528
Niedenthal PM, 2000, EUR J SOC PSYCHOL, V30, P211, DOI 10.1002/(SICI)1099-0992(200003/04)30:2<211::AID-EJSP988>3.0.CO;2-3
NIXON SJ, 1992, ALCOHOL CLIN EXP RES, V16, P684, DOI 10.1111/j.1530-0277.1992.tb00661.x
Patock-Peckham JA, 2010, J STUD ALCOHOL DRUGS, V71, P95
Pekala R. J., 2009, ALCOHOLISM TREATMENT, V27, P94, DOI DOI 10.1080/07347320802587005
Philippot P, 2003, NONVERBAL BEHAV CLIN, P209
Philippot P, 1999, ALCOHOL CLIN EXP RES, V23, P1031, DOI 10.1097/00000374-199906000-00010
Philippot P, 2005, CLAR SYMP, P17
Pombo S, 2009, ALCOHOL ALCOHOLISM, V44, P46, DOI 10.1093/alcalc/agn080
Raes F, 2006, J NERV MENT DIS, V194, P796, DOI 10.1097/01.nmd.0000240187.80270.bb
REILLY PM, 1994, J PSYCHOACTIVE DRUGS, V26, P401
Roper L, 2010, COGNITIVE THER RES, V34, P207, DOI 10.1007/s10608-009-9252-z
Russell TA, 2006, BRIT J CLIN PSYCHOL, V45, P579, DOI 10.1348/014466505X90866
RYCHTARIK RG, 1989, J STUD ALCOHOL, V50, P24
Schachner DA, 2005, J NONVERBAL BEHAV, V29, P141, DOI 10.1007/s10919-005-4847-x
SCHIFFEN.A, 1974, J PERS SOC PSYCHOL, V30, P31, DOI 10.1037/h0036643
Sheehan DV, 1997, EUR PSYCHIAT, V12, P232, DOI 10.1016/S0924-9338(97)83297-X
SHER KJ, 1991, J ABNORM PSYCHOL, V100, P427, DOI 10.1037/0021-843X.100.4.427
Sonnby-Borgstrom M, 2008, SCAND J PSYCHOL, V49, P111, DOI 10.1111/j.1467-9450.2008.00626.x
StatSoft, 2011, STATISTICA VERS 10 S
STOCKWELL T, 1979, BRIT J ADDICT, V74, P79
Tivis LJ, 1998, ALCOHOL CLIN EXP RES, V22, P902, DOI 10.1097/00000374-199806000-00021
Uekermann J, 2008, ADDICTION, V103, P726, DOI 10.1111/j.1360-0443.2008.02157.x
VONKNORRING AL, 1985, ACTA PSYCHIAT SCAND, V72, P51
VONKNORRING L, 1987, J STUD ALCOHOL, V48, P523
Windle M, 1999, DEV PSYCHOPATHOL, V11, P823, DOI 10.1017/S0954579499002345
Witkiewitz K, 2009, J CONSULT CLIN PSYCH, V77, P633, DOI 10.1037/a0015647
Young J. E., 1994, COGNITIVE THERAPY PE
ZWEBEN A, 1986, J STUD ALCOHOL, V47, P167
NR 100
TC 3
Z9 4
PU EDUCATIONAL PUBLISHING FOUNDATION-AMERICAN PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST, NE, WASHINGTON, DC 20002-4242 USA
SN 0893-164X
J9 PSYCHOL ADDICT BEHAV
JI Psychol. Addict. Behav.
PD SEP
PY 2012
VL 26
IS 3
BP 371
EP 383
DI 10.1037/a0028673
PG 13
WC Substance Abuse; Psychology, Multidisciplinary
SC Substance Abuse; Psychology
GA 005XZ
UT WOS:000308784700001
PM 22642862
ER
PT J
AU Urban, AE
AF Urban, Alexander E.
TI A Role of Genomic Copy Number Variation in the Complex Behavioral
Phenotype of Alcohol Dependence: A Commentary
SO ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
LA English
DT Article
DE Complex Disorder; Genome Variation; Segmental Duplications; Regulatory
Regions; Genome Technology
ID DUPLICATIONS; VARIANTS; AUTISM; REGION
AB In their paper Copy number variations in 6q14.1 and 5q13.2 are associated with alcohol dependence Lin and colleagues report on the association between alcohol dependence and 2 duplication CNVs in the genome sequence, one containing 8 genes within its boundaries and another that contains no genes. In this commentary, I point out some of the opportunities and challenges that arise from such a finding.
C1 Stanford Univ, Sch Med, Dept Genet, Dept Psychiat & Behav Sci, Palo Alto, CA 94304 USA.
RP Urban, AE (reprint author), Stanford Univ, Sch Med, Dept Genet, Dept Psychiat & Behav Sci, 1050A Arastradero Rd,Room A233A, Palo Alto, CA 94304 USA.
EM aeurban@stanford.edu
CR Church DM, 2010, NAT GENET, V42, P813, DOI 10.1038/ng1010-813
Coe BP, 2012, AM J MED GENET C, V160C, P118, DOI 10.1002/ajmg.c.31327
Crespi B, 2010, P NATL ACAD SCI USA, V107, P1736, DOI 10.1073/pnas.0906080106
ELIA J, 2012, NAT GENET, V44, P78, DOI DOI 10.1038/ng.1013
Girirajan S, 2011, PLOS GENET, V7, DOI 10.1371/journal.pgen.1002334
Kasowski M, 2010, SCIENCE, V328, P232, DOI 10.1126/science.1183621
Lander ES, 2001, NATURE, V409, P860, DOI 10.1038/35057062
Lin P, 2012, ALCOHOL CLIN EXP RES, V36, P1512, DOI 10.1111/j.1530-0277.2012.01758.x
Mefford HC, 2009, CURR OPIN GENET DEV, V19, P196, DOI 10.1016/j.gde.2009.04.003
Merla G, 2010, HUM GENET, V128, P3, DOI 10.1007/s00439-010-0827-2
Mills RE, 2011, NATURE, V470, P59, DOI 10.1038/nature09708
Ricard G, 2010, PLOS BIOL, V8, DOI 10.1371/journal.pbio.1000543
Sanders SJ, 2011, NEURON, V70, P863, DOI 10.1016/j.neuron.2011.05.002
Stefansson H, 2005, NAT GENET, V37, P129, DOI 10.1038/ng1508
Altshuler D, 2010, NATURE, V467, P1061, DOI 10.1038/nature09534
Williams NM, 2012, AM J PSYCHIAT, V169, P195, DOI 10.1176/appi.ajp.2011.11060822
NR 16
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0145-6008
J9 ALCOHOL CLIN EXP RES
JI Alcoholism (NY)
PD SEP
PY 2012
VL 36
IS 9
BP 1483
EP 1486
DI 10.1111/j.1530-0277.2012.01915.x
PG 4
WC Substance Abuse
SC Substance Abuse
GA 001BQ
UT WOS:000308435200003
PM 22909245
ER
PT J
AU Li, XH
Zou, H
Brown, WT
AF Li, Xiaohong
Zou, Hua
Brown, W. Ted
TI Genes associated with autism spectrum disorder
SO BRAIN RESEARCH BULLETIN
LA English
DT Review
DE Autism spectrum disorder; Candidate genes; Genetic susceptibility;
Etiology
ID SEROTONIN TRANSPORTER GENE; FAMILY-BASED ASSOCIATION; CHINESE HAN
POPULATION; RECEPTOR SUBUNIT GENES; CARRIER SLC25A12 GENE; COPY NUMBER
VARIATION; LINKAGE-DISEQUILIBRIUM; NEUROLIGIN GENES; KOREAN TRIOS;
GENOME-WIDE
AB Autism spectrum disorder (ASD) is a heterogeneous grouping of neurodevelopmental disorders characterized by impairment in social interaction, verbal communication and repetitive/stereotypic behaviors. Much evidence suggests that ASD is multifactorial with a strong genetic basis, but the underlying mechanisms are far from clear. Recent advances in genetic technologies are beginning to shed light on possible etiologies of ASD. This review discusses current evidence for several widely studied candidate ASD genes, as well as various rare genes that supports their relationship to the etiology of ASD. The majority of the data are based on molecular, cytogenetic, linkage and association studies of autistic subjects, but newer methods, including whole-exome sequencing, are also beginning to make significant contributions to our understanding of autism. Published by Elsevier Inc.
C1 [Li, Xiaohong; Zou, Hua] New York State Inst Basic Res Dev Disabil, Dept Neurochem, Staten Isl, NY 10314 USA.
[Brown, W. Ted] New York State Inst Basic Res Dev Disabil, Dept Human Genet, Staten Isl, NY 10314 USA.
[Zou, Hua] Nanfang Hosp, Dept Obstet & Gynecol, Guangzhou, Guangdong, Peoples R China.
RP Li, XH (reprint author), New York State Inst Basic Res Dev Disabil, Dept Neurochem, 1050 Forest Hill Rd, Staten Isl, NY 10314 USA.
EM xiaohong.li@omr.state.ny.us
CR Abrahams BS, 2008, NAT REV GENET, V9, P341, DOI 10.1038/nrg2346
Alarcon M, 2008, AM J HUM GENET, V82, P150, DOI 10.1016/j.ajhg.2007.09.005
Aldinger KA, 2010, DIS MODEL MECH, V3, P3, DOI 10.1242/dmm.004663
Alvarez R.A., 2008, HUM MOL GENET, V17, P3887
Anderson BM, 2009, NEUROGENETICS, V10, P209, DOI 10.1007/s10048-009-0171-7
[Anonymous], 2007, MMWR SURVEILLANCE SU, V56, P12
[Anonymous], 2007, MMWR SURVEILLANCE SU, V56, P1
Arking DE, 2008, AM J HUM GENET, V82, P160, DOI 10.1016/j.ajhg.2007.09.015
Ashley-Koch AE, 2007, PSYCHIAT GENET, V17, P221, DOI 10.1097/YPG.0b013e32809c2f75
Autism and Developmental Disabilities Monitoring Network Surveillance Year 2006 Principal Investigators; Centers for Disease Control and Prevention (CDC), 2009, MMWR SURVEILLANCE SU, V58, P1
Babatz TD, 2009, AUTISM RES, V2, P359, DOI 10.1002/aur.107
Bailey A, 1998, BRAIN, V121, P889, DOI 10.1093/brain/121.5.889
BAILEY A, 1995, PSYCHOL MED, V25, P63
Bakkaloglu B, 2008, AM J HUM GENET, V82, P165, DOI 10.1016/j.ajhg.2007.09.017
Barnby G, 2005, AM J HUM GENET, V76, P950, DOI 10.1086/430454
Baron-Cohen S, 2005, SCIENCE, V310, P819, DOI 10.1126/science.1115455
Betancur C, 2009, TRENDS NEUROSCI, V32, P402, DOI 10.1016/j.tins.2009.04.003
Betancur C, 2002, MOL PSYCHIATR, V7, P67, DOI 10.1038/sj/mp/4000923
Betancur C, 2011, BRAIN RES, V1380, P42, DOI 10.1016/j.brainres.2010.11.078
Bilguvar K, 2010, NATURE, V467, P207, DOI 10.1038/nature09327
Blasi F, 2006, EUR J HUM GENET, V14, P123, DOI 10.1038/sj.ejhg.5201444
Blasi F, 2006, AM J MED GENET B, V141B, P220, DOI 10.1002/ajmg.b.30287
Bolton PF, 2004, PSYCHIAT GENET, V14, P131, DOI 10.1097/00041444-200409000-00002
Burbach JPH, 2009, TRENDS NEUROSCI, V32, P69, DOI 10.1016/j.tins.2008.11.002
Buxbaum JD, 2001, AM J HUM GENET, V68, P1514, DOI 10.1086/320588
Buxbaum JD, 2002, MOL PSYCHIATR, V7, P311, DOI 10.1038/sj/mp/4001011
Caglayan AO, 2010, DEV MED CHILD NEUROL, V52, P130, DOI 10.1111/j.1469-8749.2009.03523.x
Cai GQ, 2008, BMC MED GENOMICS, V1, DOI 10.1186/1755-8794-1-50
Campbell DB, 2006, P NATL ACAD SCI USA, V103, P16834, DOI 10.1073/pnas.0605296103
Campbell DB, 2010, AM J MED GENET B, V153B, P438, DOI 10.1002/ajmg.b.30998
Campbell DB, 2007, ANN NEUROL, V62, P243, DOI 10.1002/ana.21180
Campbell DB, 2008, AUTISM RES, V1, P159, DOI 10.1002/aur.27
Chien WH, 2010, PROG NEURO-PSYCHOPH, V34, P189, DOI 10.1016/j.pnpbp.2009.11.004
Cho IH, 2007, BRAIN RES, V1139, P34, DOI 10.1016/j.brainres.2007.01.002
Cho SC, 2009, PSYCHIAT GENET, V19, P177, DOI 10.1097/YPG.0b013e32832bdafa
Choi M, 2009, P NATL ACAD SCI USA, V106, P19096, DOI 10.1073/pnas.0910672106
Christian SL, 2008, BIOL PSYCHIAT, V63, P1111, DOI 10.1016/j.biopsych.2008.01.009
Cook EH, 1998, AM J HUM GENET, V62, P1077, DOI 10.1086/301832
Cook EH, 1997, MOL PSYCHIATR, V2, P247
Coon H, 2005, AM J MED GENET B, V135B, P42, DOI 10.1002/ajmg.b.30168
Coutinho AM, 2004, MOL PSYCHIATR, V9, P264, DOI 10.1038/sj.mp.4001409
Coutinho AM, 2007, HUM GENET, V121, P243, DOI 10.1007/s00439-006-0301-3
Cukier HN, 2009, AUTISM RES, V2, P258, DOI 10.1002/aur.96
Curran S, 2005, AM J MED GENET B, V137B, P25, DOI 10.1002/ajmg.b.30126
Curran T, 1998, BRAIN RES REV, V26, P285, DOI 10.1016/S0165-0173(97)00035-0
Cusco I, 2009, HUM MOL GENET, V18, P1795, DOI 10.1093/hmg/ddp092
DARCANGELO G, 1995, NATURE, V374, P719, DOI 10.1038/374719a0
Del A.A., 1998, J BIOL CHEM, V273, P23327
Del R.J., 1997, NATURE, V385, P70
Depienne C, 2009, BIOL PSYCHIAT, V66, P349, DOI 10.1016/j.biopsych.2009.01.025
Devlin B, 2004, AM J MED GENET B, V126B, P46, DOI 10.1002/ajmg.b.20125
Dutta S, 2007, CELL MOL NEUROBIOL, V27, P1035, DOI 10.1007/s10571-007-9193-6
Dutta S, 2007, AM J MED GENET B, V144B, P106, DOI 10.1002/ajmg.b.30419
Fatemi SH, 2002, CELL MOL NEUROBIOL, V22, P139, DOI 10.1023/A:1019857620251
Fatemi SH, 2001, J AUTISM DEV DISORD, V31, P529, DOI 10.1023/A:1013234708757
Fatemi SH, 2005, BIOL PSYCHIAT, V57, P777, DOI 10.1016/j.biopsych.2004.12.018
Filipek PA, 2003, ANN NEUROL, V53, P801, DOI 10.1002/ana.10596
Gauthier J, 2005, AM J MED GENET B, V132B, P74, DOI 10.1002/ajmg.b.30066
Geschwind DH, 2007, CURR OPIN NEUROBIOL, V17, P103, DOI 10.1016/j.conb.2007.01.009
Glessner JT, 2009, NATURE, V459, P569, DOI 10.1038/nature07953
GOFFINET AM, 1983, ANAT EMBRYOL, V168, P73, DOI 10.1007/BF00305400
GOFFINET AM, 1983, J COMP NEUROL, V219, P10, DOI 10.1002/cne.902190103
Goffinet A M, 1984, Brain Res, V319, P261
Green JJ, 2010, NEUROTHERAPEUTICS, V7, P250, DOI 10.1016/j.nurt.2010.05.006
Gregory SG, 2009, BMC MED, V7, DOI 10.1186/1741-7015-7-62
Guhathakurta S, 2006, BRAIN RES, V1092, P28, DOI 10.1016/j.brainres.2006.03.078
Guhathakurta S, 2008, BRAIN RES, V1240, P12, DOI 10.1016/j.brainres.2008.08.063
Guhathakurta S, 2009, NEUROCHEM INT, V55, P754, DOI 10.1016/j.neuint.2009.07.008
Hoffman EJ, 2010, J AM ACAD CHILD PSY, V49, P736, DOI 10.1016/j.jaac.2010.03.016
Huang CH, 2008, AM J MED GENET B, V147B, P903, DOI 10.1002/ajmg.b.30720
Hutcheson Holli B, 2004, BMC Med Genet, V5, P12, DOI 10.1186/1471-2350-5-12
Jackson PB, 2009, AUTISM RES, V2, P232, DOI 10.1002/aur.87
Jacob S, 2007, NEUROSCI LETT, V417, P6, DOI 10.1016/j.neulet.2007.02.001
Jamain S, 2002, MOL PSYCHIATR, V7, P302, DOI 10.1038/sj/mp/4000979
Jamain S, 2003, NAT GENET, V34, P27, DOI 10.1038/ng1136
Junaid MA, 2004, AM J MED GENET A, V131A, P11, DOI 10.1002/ajmg.a.30349
Kim SA, 2007, NEUROSCI RES, V58, P332, DOI 10.1016/j.neures.2007.03.002
Kim SA, 2006, NEUROPSYCHOBIOLOGY, V54, P160, DOI 10.1159/000098651
Kim SJ, 2002, MOL PSYCHIATR, V7, P278, DOI 10.1038/sj/mp/4001033
Kim SJ, 2008, AM J MED GENET B, V147B, P1116, DOI 10.1002/ajmg.b.30733
King M, 2009, INT J EPIDEMIOL, V38, P1224, DOI 10.1093/ije/dyp261
Klauck SM, 1997, HUM MOL GENET, V6, P2233, DOI 10.1093/hmg/6.13.2233
Koishi S, 2006, BRAIN DEV-JPN, V28, P257, DOI 10.1016/j.braindev.2005.09.003
Krebs MO, 2002, MOL PSYCHIATR, V7, P801, DOI 10.1038/sj.mp.4001071
Kumar RA, 2008, HUM MOL GENET, V17, P628, DOI 10.1093/hmg/ddm376
Kumar RA, 2009, CURR NEUROL NEUROSCI, V9, P188, DOI 10.1007/s11910-009-0029-2
Kumar RA, 2010, J MED GENET, V47, P81, DOI 10.1136/jmg.2008.065821
Kwasnicka-Crawford DA, 2007, J AUTISM DEV DISORD, V37, P694, DOI 10.1007/s10803-006-0225-8
Lerer E, 2008, MOL PSYCHIATR, V13, P980, DOI 10.1038/sj.mp.4002087
Levitt P, 2004, TRENDS NEUROSCI, V27, P400, DOI 10.1016/j.tins.2004.05.008
Levitt P, 2009, J CLIN INVEST, V119, P747, DOI 10.1172/JCI37934
Li H, 2008, AM J MED GENET B, V147B, P194, DOI 10.1002/ajmg.b.30584
Li J, 2004, AM J MED GENET B, V126B, P51, DOI 10.1002/ajmg.b.20122
Lintas C, 2009, J MED GENET, V46, P1, DOI 10.1136/jmg.2008.060871
Liu K, 2010, DEMOGRAPHY, V47, P327
Liu XX, 2010, J HUM GENET, V55, P137, DOI 10.1038/jhg.2009.140
LORD C, 1989, J AUTISM DEV DISORD, V19, P185, DOI 10.1007/BF02211841
LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
Lucht MJ, 2009, PROG NEURO-PSYCHOPH, V33, P860, DOI 10.1016/j.pnpbp.2009.04.004
Ma DQ, 2005, AM J HUM GENET, V77, P377, DOI 10.1086/433195
Ma DQ, 2009, ANN HUM GENET, V73, P263, DOI 10.1111/j.1469-1809.2009.00523.x
Ma DQ, 2007, MOL PSYCHIATR, V12, P376, DOI 10.1038/sj.mp.4001927
Ma DQ, 2010, AM J MED GENET B, V153B, P477, DOI 10.1002/ajmg.b.31003
Maestrini E, 1999, AM J MED GENET, V88, P492, DOI 10.1002/(SICI)1096-8628(19991015)88:5<492::AID-AJMG11>3.0.CO;2-X
Marshall CR, 2008, AM J HUM GENET, V82, P477, DOI 10.1016/j.ajhg.2007.12.009
Martin ER, 2000, AM J MED GENET, V96, P43, DOI 10.1002/(SICI)1096-8628(20000207)96:1<43::AID-AJMG9>3.0.CO;2-3
Marui T, 2010, INT J NEUROPSYCHOPH, V13, P443, DOI 10.1017/S1461145709990903
Marui T, 2009, INT J NEUROPSYCHOPH, V12, P1, DOI 10.1017/S1461145708009127
McCauley JL, 2004, AM J MED GENET B, V131B, P51, DOI 10.1002/ajmg.b.30038
McCauley JL, 2004, AM J MED GENET B, V127B, P104, DOI 10.1002/ajmg.b.20151
McCauley JL, 2005, BMC MED GENET, V6, DOI 10.1186/1471-2350-6-1
McDougle CJ, 1996, ARCH GEN PSYCHIAT, V53, P1001
Menold MM, 2001, J NEUROGENET, V15, P245
Nakatani J, 2009, CELL, V137, P1235, DOI 10.1016/j.cell.2009.04.024
Nonkin A.R., 2010, J AUSTISM DEV DISORD
Noor A, 2010, SCI TRANSL MED, V2, DOI 10.1126/scitranslmed.3001267
Nurmi EL, 2001, GENOMICS, V77, P105, DOI 10.1006/geno.2001.6617
O'Roak BJ, 2008, AUTISM RES, V1, P4, DOI 10.1002/aur.3
Pampanos A, 2009, GENET TEST MOL BIOMA, V13, P611, DOI 10.1089/gtmb.2009.0005
PARK M, 1986, CELL, V45, P895, DOI 10.1016/0092-8674(86)90564-7
Persico AM, 2000, AM J MED GENET, V96, P123, DOI 10.1002/(SICI)1096-8628(20000207)96:1<123::AID-AJMG24>3.0.CO;2-N
Persico AM, 2001, MOL PSYCHIATR, V6, P150, DOI 10.1038/sj.mp.4000850
Philippi A, 2007, BMC MED GENET, V8, DOI 10.1186/1471-2350-8-74
Piggot J, 2009, NEUROSCIENCE, V164, P247, DOI 10.1016/j.neuroscience.2009.05.054
Pinto D, 2010, NATURE, V466, P368, DOI 10.1038/nature09146
Poot M, 2010, NEUROGENETICS, V11, P81, DOI 10.1007/s10048-009-0205-1
Powell EM, 2001, NEURON, V30, P79, DOI 10.1016/S0896-6273(01)00264-1
Qiao Y, 2009, J MED GENET, V46, P680, DOI 10.1136/jmg.2009.066795
Qin J, 2009, BMC MED GENET, V10, DOI 10.1186/1471-2350-10-61
Rabionet R, 2004, NEUROSCI LETT, V372, P209, DOI 10.1016/j.neulet.2004.09.037
Rabionet Raquel, 2006, Am J Psychiatry, V163, P929, DOI 10.1176/appi.ajp.163.5.929
RAMAMOORTHY S, 1993, P NATL ACAD SCI USA, V90, P2542, DOI 10.1073/pnas.90.6.2542
Ramoz N, 2008, AM J MED GENET B, V147B, P1152, DOI 10.1002/ajmg.b.30739
Ramoz N, 2006, BIOL PSYCHIAT, V60, P186, DOI 10.1016/j.biopsych.2006.01.009
Ramoz N, 2006, AM J MED GENET B, V141B, P861, DOI 10.1002/ajmg.b.30356
Ramoz N, 2004, AM J PSYCHIAT, V161, P662, DOI 10.1176/appi.ajp.161.4.662
Rehnstrom K, 2008, AM J MED GENET B, V147B, P124, DOI 10.1002/ajmg.b.30582
Robinson PN, 2010, GENOME BIOL, V11, DOI 10.1186/gb-2010-11-12-144
Rossi E, 2008, EUR J MED GENET, V51, P631, DOI 10.1016/j.ejmg.2008.06.010
Sacco R, 2007, BMC MED GENET, V8, DOI 10.1186/1471-2350-8-11
Sakurai T, 2006, PSYCHIAT GENET, V16, P251, DOI 10.1097/01.ypg.0000242196.81891.c9
Sanders SS, 2011, CLIN GENET, V79, P132, DOI 10.1111/j.1399-0004.2010.01585.x
Scherer SW, 2003, SCIENCE, V300, P767, DOI 10.1126/science.1083423
Sebat J, 2007, SCIENCE, V316, P445, DOI 10.1126/science.1138659
Segurado R, 2005, AM J PSYCHIAT, V162, P2182, DOI 10.1176/appi.ajp.162.11.2182
Serajee FJ, 2006, GENOMICS, V87, P75, DOI 10.1016/j.ygeno.2005.09.008
Shao YJ, 2003, AM J HUM GENET, V72, P539, DOI 10.1086/367846
Shao YJ, 2002, AM J HUM GENET, V70, P1058, DOI 10.1086/339765
Shen YP, 2010, PEDIATRICS, V125, pE727, DOI 10.1542/peds.2009-1684
Shimizu E, 2000, SCIENCE, V290, P1170, DOI 10.1126/science.290.5494.1170
Shinawi M, 2010, J MED GENET, V47, P332, DOI 10.1136/jmg.2009.073015
Shuang M, 2004, AM J MED GENET B, V131B, P48, DOI 10.1002/ajmg.b.30025
Silverman JM, 2008, AM J MED GENET B, V147B, P408, DOI 10.1002/ajmg.b.30614
Skaar DA, 2005, MOL PSYCHIATR, V10, P563, DOI 10.1038/sj.mp.4001614
Sousa I, 2009, EUR J HUM GENET, V17, P749, DOI 10.1038/ejhg.2008.215
STEFFENBURG S, 1989, J CHILD PSYCHOL PSYC, V30, P405, DOI 10.1111/j.1469-7610.1989.tb00254.x
Strauss KA, 2006, NEW ENGL J MED, V354, P1370, DOI 10.1056/NEJMoa052773
Streit ACE, 1997, CIBA F SYMP, V212, P155
Sutcliffe JS, 2003, BMC GENOMICS, V4, DOI 10.1186/1471-2164-4-15
Sutcliffe JS, 2005, AM J HUM GENET, V77, P265, DOI 10.1086/432648
Szatmari P, 2007, NAT GENET, V39, P319, DOI 10.1038/ng1985
Takumi T, 2010, BRAIN DEV-JPN, V32, P753, DOI 10.1016/j.braindev.2010.05.001
Talebizadeh Z, 2004, J AUTISM DEV DISORD, V34, P735, DOI 10.1007/s10803-004-5295-x
Talebizadeh Z, 2006, J MED GENET, V43, DOI 10.1136/jmg.2005.036897
Tordjman S, 2001, MOL PSYCHIATR, V6, P434, DOI 10.1038/sj.mp.4000873
Turunen JA, 2008, AUTISM RES, V1, P189, DOI 10.1002/aur.25
Van Naarden BK, 2007, MMWR SURVEILL SUMM, V56, P29
Vincent JB, 2004, AM J MED GENET B, V129B, P82, DOI 10.1002/ajmg.b.30069
Vissers LELM, 2010, NAT GENET, V42, P1109, DOI 10.1038/ng.712
Wang K, 2009, NATURE, V459, P528, DOI 10.1038/nature07999
Weiss LA, 2009, NATURE, V461, P802, DOI 10.1038/nature08490
Wermter AK, 2008, AM J MED GENET B, V147B, P535, DOI 10.1002/ajmg.b.30618
Williams JG, 2006, ARCH DIS CHILD, V91, P8, DOI 10.1136/adc.2004.062083
Wu SP, 2005, BIOL PSYCHIAT, V58, P74, DOI 10.1016/j.biopsych.2005.03.013
Wu SP, 2005, NEUROSCI LETT, V381, P1, DOI 10.1016/j.neulet.2005.01.073
Wu SP, 2007, AM J MED GENET B, V144B, P492, DOI 10.1002/ajmg.b.30495
Wu YY, 2008, PROG NEURO-PSYCHOPH, V32, P1740, DOI 10.1016/j.pnpbp.2008.07.019
Yamasue H, 2009, PSYCHIAT CLIN NEUROS, V63, P129, DOI 10.1111/j.1440-1819.2009.01944.x
Yan J, 2008, PSYCHIAT GENET, V18, P204, DOI 10.1097/YPG.0b013e3282fb7fe6
Yan J, 2005, MOL PSYCHIATR, V10, P329, DOI 10.1038/sj.mp.4001629
Ylisaukko-oja T, 2005, EUR J HUM GENET, V13, P1285, DOI 10.1038/sj.ejhg.5201474
Yoo HK, 2009, YONSEI MED J, V50, P304, DOI 10.3349/ymj.2009.50.2.304
Zhong N, 1999, NEUROGENETICS, V2, P129, DOI 10.1007/s100480050064
NR 183
TC 28
Z9 29
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0361-9230
J9 BRAIN RES BULL
JI Brain Res. Bull.
PD SEP 1
PY 2012
VL 88
IS 6
BP 543
EP 552
DI 10.1016/j.brainresbull.2012.05.017
PG 10
WC Neurosciences
SC Neurosciences & Neurology
GA 995XT
UT WOS:000308049300001
PM 22688012
ER
PT J
AU Davis, M
AF Davis, Michael
TI The Editor's offering
SO DIVING AND HYPERBARIC MEDICINE
LA English
DT Editorial Material
DE Autism; hyperbaric oxygen therapy; research; editorials
ID HYPERBARIC-OXYGEN THERAPY
CR Chungpaibulpatana Jessada, 2008, Journal of the Medical Association of Thailand, V91, P1232
Ghanizadeh Ahmad, 2012, Med Gas Res, V2, P13, DOI 10.1186/2045-9912-2-13
Kot J, 2011, DIVING HYPERB MED, V41, P101
Rossignol DA, 2009, BMC PEDIATR, V9, DOI 10.1186/1471-2431-9-21
Sampanthavivat M, 2012, DIVING HYPERB MED, V42, P128
NR 5
TC 0
Z9 0
PU SOUTH PACIFIC UNDERWATER MED SOC
PI MELBOURNE
PA C/O AUSTRALIAN & NEW ZEALAND COLL ANAESTHETISTS, 630 ST KILDA RD,
MELBOURNE, VIC 3004, AUSTRALIA
SN 1833-3516
J9 DIVING HYPERB MED
JI Diving Hyperb. Med.
PD SEP
PY 2012
VL 42
IS 3
BP 125
EP 125
PG 1
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 002AO
UT WOS:000308502400001
ER
PT J
AU Sampanthavivat, M
Singkhwa, W
Chaiyakul, T
Karoonyawanich, S
Ajpru, H
AF Sampanthavivat, Mayuree
Singkhwa, Wararat
Chaiyakul, Thanasawat
Karoonyawanich, Sangdaw
Ajpru, Haruthai
TI Hyperbaric oxygen in the treatment of childhood autism: a randomised
controlled trial
SO DIVING AND HYPERBARIC MEDICINE
LA English
DT Article
DE Autism; hyperbaric oxygen therapy; hyperbaric research
ID CEREBRAL-BLOOD-FLOW; THERAPY; DISORDERS; PRESSURE; CHILDREN; PALSY
AB (Sampanthavivat M, Singkhwa W, Chaiyakul T, Karoonyawanich S, Ajpru H. Hyperbaric oxygen in the treatment of childhood autism: a randomised controlled trial. Diving and Hyperbaric Medicine. 2012;42(3):128-133.)
Background: Promising results with hyperbaric therapy for children with autism have been reported, but most involved the use of only mild pressure with oxygen supplementation. To date, there has been no randomised, blinded trial of 100% oxygen administered at hyperbaric pressure. This study evaluated the efficacy of hyperbaric oxygen therapy (HBOT).
Methods: Sixty Thai children with autism, aged three to nine years, were randomly assigned to receive 20 one-hour sessions of either HBOT at 153 kPa (1.5 ATA) or sham air at 116 kPa (1.15 ATA). Effects on behaviour were measured using the Autism Treatment Evaluation Checklist score (ATEC) and clinical improvement was measured with the Clinical Global Impression (CGI) system; in particular the clinical change (CGIC) and severity (CGIS) sub-scores. These were evaluated by parents and clinicians, both of whom were blinded to the actual exposure.
Results: The mean total ATEC scores by both parents and clinicians were significantly improved after intervention in both arms of the study compared to the score before intervention (P < 0.001 in both groups by parents, P = 0.015 in HBOT group and P = 0.004 in sham group by clinician). There were no statistically significant differences in average percentage changes of total ATEC score and all subscales scores when comparing the HBOT and sham air groups, either by parents or clinicians. Changes in the CGI scores following intervention were inconsistent between parents and clinicians. For severity scores (CGIS), parents rated their children as more improved following HBOT (P = 0.005), while the clinicians found no significant differences (P = 0.10). On the other hand, for change scores (CGIC) the clinicians indicated greater improvement following HBOT (P = 0.03), but the parents found no such difference (P = 0.28)
Conclusions: Children with autism who received 20 sessions of either HBOT or a sham air exposure had significant improvements in overall behaviour but there were no significant differences in improvement between groups. The inconsistent changes on CGI sub-scores between parents and clinicians are difficult to interpret, but no overall clinically significant benefit from HBOT could be shown. Both interventions were safe and well tolerated with minimal side effect from middle ear barotraumas.
C1 [Chaiyakul, Thanasawat] Royal Thai Navy, Naval Med Dept, Div Underwater & Aviat Med, Bangkok 10600, Thailand.
[Sampanthavivat, Mayuree; Singkhwa, Wararat] Royal Thai Navy, Somdej Prapinklao Hosp, Naval Med Dept, Bangkok 10600, Thailand.
[Karoonyawanich, Sangdaw; Ajpru, Haruthai] Royal Thai Navy, Coll Nursing, Naval Med Dept, Bangkok 10600, Thailand.
RP Chaiyakul, T (reprint author), Royal Thai Navy, Naval Med Dept, Div Underwater & Aviat Med, 504-54 Taksin Rd, Bangkok 10600, Thailand.
EM thanasawat.c@navy.mi.th
FU HM Queen Sirikit Naval Hospital, Royal Thai Navy Foundation
FX Mayuree Sampanthavivat is a board members of HM Queen Sirikit Naval
Hospital, Royal Thai Navy Foundation who funded this research. The other
authors report no potential conflict of interest.This research was
funded by HM Queen Sirikit Naval Hospital, Royal Thai Navy Foundation
and was presented at the 17th International Congress on Hyperbaric
Medicine, 2011. We would like to acknowledge Drs Fakjit Poonpol,
Nareerat Kamonpakorn, Arom Kaewboonchu and Pasinee Taycharpipranai for
study design and clinical evaluation, Prawin Yanapirak, Kaewta
Kitkamhang, Wuttichai Banjongpru and the hyperbaric care team from the
Division of Underwater and Aviation Medicine, Naval Medical Department
for their hyperbaric care and technical control, Maneerat Narangsiya for
data collection, and Pawinee Buranaraktham for manuscript preparation.
The authors wish to express special thanks to Drs Michael Bennett and
Simon Mitchell for reviewing this manuscript and offering valuable
advice prior to submission.
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
[Anonymous], 2000, AUTISM TREATMENT EVA
[Anonymous], 2009, POS STAT TREATM AUT
Campbell CA, 2011, AUT CHILD PSYCHO, P25, DOI 10.1007/978-1-4419-8065-6_3
Carson S, 2005, CLIN REHABIL, V19, P819, DOI 10.1191/0269215505cr907oa
Chungpaibulpatana Jessada, 2008, Journal of the Medical Association of Thailand, V91, P1232
Connolly AM, 1999, J PEDIATR-US, V134, P607, DOI 10.1016/S0022-3476(99)70248-9
Critchley HD, 2000, BRAIN, V123, P2203, DOI 10.1093/brain/123.11.2203
Gesel LB, 2008, HYPERBARIC OXYGEN TH
Gill AL, 2004, QJM-INT J MED, V97, P385, DOI 10.1093/qjmed/hch074
Granowitz EV, 2002, UNDERSEA HYPERBAR M, V29, P216
Guy W, 1976, CLIN GLOBAL IMPRESSI
Jyonouchi H, 2000, NEUROPSYCHOBIOLOGY, V76, P76
Jyonouchi H, 2005, NEUROPSYCHOBIOLOGY, V51, P77, DOI 10.1159/000084164
Kot J, 2011, DIVING HYPERB MED, V41, P101
Leach RM, 1998, BRIT MED J, V317, P1140
McDonagh MS, 2003, AHRQ PUBLICATION
McDonagh MS, 2007, DEV MED CHILD NEUROL, V49, P942
Nuthall G, 2000, PEDIATRICS, V106, part. no., DOI 10.1542/peds.106.6.e80
Ohnishi T, 2000, BRAIN, V123, P1838, DOI 10.1093/brain/123.9.1838
Ozonoff S, 2003, AUTISM SPECTRUM DISO, P165
Penkae L, 1998, HDB AUTISM, P1
Poolsuppasit S, 2005, J MENTAL HLTH THAILA, V13, P10
Rimland B, 1999, AUTISM TREATMENT EVA
Rossignol DA, 2009, BMC PEDIATR, V9, DOI 10.1186/1471-2431-9-21
Rossignol DA, 2008, HYPERBARIC OXYGEN NE, P209
Shiratsuch H, 2005, AM J SURG, V190, P757, DOI 10.1016/j.amjsurg.2005.07.016
Starkstein SE, 2000, J NEUROPSYCH CLIN N, V12, P370, DOI 10.1176/appi.neuropsych.12.3.370
Whiteley P, 2010, AUTISM INSIGHTS, V2, P17
Zilbovicius M, 2000, AM J PSYCHIAT, V157, P1988, DOI 10.1176/appi.ajp.157.12.1988
NR 30
TC 5
Z9 5
PU SOUTH PACIFIC UNDERWATER MED SOC
PI MELBOURNE
PA C/O AUSTRALIAN & NEW ZEALAND COLL ANAESTHETISTS, 630 ST KILDA RD,
MELBOURNE, VIC 3004, AUSTRALIA
SN 1833-3516
J9 DIVING HYPERB MED
JI Diving Hyperb. Med.
PD SEP
PY 2012
VL 42
IS 3
BP 128
EP 133
PG 6
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 002AO
UT WOS:000308502400004
PM 22987458
ER
PT J
AU Lesca, G
Rudolf, G
Labalme, A
Hirsch, E
Arzimanoglou, A
Genton, P
Motte, J
de Saint Martin, A
Valenti, MP
Boulay, C
De Bellescize, J
Keo-Kosal, P
Boutry-Kryza, N
Edery, P
Sanlaville, D
Szepetowski, P
AF Lesca, Gaetan
Rudolf, Gabrielle
Labalme, Audrey
Hirsch, Edouard
Arzimanoglou, Alexis
Genton, Pierre
Motte, Jacques
de Saint Martin, Anne
Valenti, Maria-Paola
Boulay, Clotilde
De Bellescize, Julitta
Keo-Kosal, Pascale
Boutry-Kryza, Nadia
Edery, Patrick
Sanlaville, Damien
Szepetowski, Pierre
TI Epileptic encephalopathies of the Landau-Kleffner and continuous spike
and waves during slow-wave sleep types: Genomic dissection makes the
link with autism
SO EPILEPSIA
LA English
DT Article
DE Epilepsy; Slow-wave sleep; Landau-Kleffner; Autism; Gene
ID COPY NUMBER VARIANTS; ELECTRICAL STATUS EPILEPTICUS; IDIOPATHIC ROLANDIC
EPILEPSY; SPECTRUM DISORDERS; LANGUAGE IMPAIRMENT; WIDE ASSOCIATION;
GENE; MUTATIONS; SPEECH; EEG
AB Purpose: The continuous spike and waves during slow-wave sleep syndrome (CSWSS) and the Landau-Kleffner (LKS) syndrome are two rare epileptic encephalopathies sharing common clinical features including seizures and regression. Both CSWSS and LKS can be associated with the electroencephalography pattern of electrical status epilepticus during slow-wave sleep and are part of a clinical continuum that at its benign end also includes rolandic epilepsy (RE) with centrotemporal spikes. The CSWSS and LKS patients can also have behavioral manifestations that overlap the spectrum of autism disorders (ASD). An impairment of brain development and/or maturation with complex interplay between genetic predisposition and nongenetic factors has been suspected. A role for autoimmunity has been proposed but the pathophysiology of CSWSS and of LKS remains uncharacterized. Methods: In recent years, the participation of rare genomic alterations in the susceptibility to epileptic and autistic disorders has been demonstrated. The involvement of copy number variations (CNVs) in 61 CSWSS and LKS patients was questioned using comparative genomic hybridization assays coupled with validation by quantitative polymerase chain reaction (PCR). Key Findings: Whereas the patients showed highly heterogeneous in genomic architecture, several potentially pathogenic alterations were detected. A large number of these corresponded to genomic regions or genes (ATP13A4, CDH9, CDH13, CNTNAP2, CTNNA3, DIAPH3, GRIN2A, MDGA2, SHANK3) that have been either associated with ASD for most of them, or involved in speech or language impairment, or in RE. Particularly, CNVs encoding cell adhesion proteins (cadherins, protocadherins, contactins, catenins) were detected with high frequency (approximate to 20% of the patients) and significant enrichment (cell adhesion: p = 0.027; cell adhesion molecule binding: p = 9.27 x 10-7). Significance: Overall our data bring the first insights into the possible molecular pathophysiology of CSWSS and LKS. The overrepresentation of cell adhesion genes and the strong overlap with the genetic, genomic and molecular ASD networks, provide an exciting and unifying view on the clinical links among CSWSS, LKS, and ASD.
C1 [Szepetowski, Pierre] Genet Epilepsies Isolees & Associees GEIA Grp, Inst Neurobiolo Mediterranee INMED, INSERM, UMR901, F-13273 Marseille 09, France.
[Lesca, Gaetan; Labalme, Audrey; Edery, Patrick; Sanlaville, Damien] Lyon Hosp Civils, Dept Constitut Cytogenet, Lyon, France.
[Lesca, Gaetan; Boutry-Kryza, Nadia; Edery, Patrick; Sanlaville, Damien] Univ Lyon 1, F-69365 Lyon, France.
[Lesca, Gaetan; Arzimanoglou, Alexis; Boutry-Kryza, Nadia; Edery, Patrick; Sanlaville, Damien] CNRS, CRNL, UMR 5292, INSERM,U1028, Lyon, France.
[Rudolf, Gabrielle; Hirsch, Edouard; Valenti, Maria-Paola; Boulay, Clotilde] Strasbourg Univ Hosp, Dept Neurol, Strasbourg, France.
[Rudolf, Gabrielle; Hirsch, Edouard] Strasbourg Univ, Strasbourg, France.
[Arzimanoglou, Alexis; De Bellescize, Julitta; Keo-Kosal, Pascale] Lyon Hosp Civils, Dept Pediat Epileptol, Lyon, France.
[Genton, Pierre] Henri Gastaut Hosp, Marseille, France.
[Motte, Jacques] Amer Mem Hosp, Pediat Dept A, Reims, France.
[de Saint Martin, Anne] Strasbourg Univ Hosp, Dept Pediat 1, Strasbourg, France.
[Boutry-Kryza, Nadia] Lyon Hosp Civils, Mol Genet Lab, Lyon, France.
[Szepetowski, Pierre] Aix Marseille Univ, Marseille, France.
RP Szepetowski, P (reprint author), Genet Epilepsies Isolees & Associees GEIA Grp, Inst Neurobiolo Mediterranee INMED, INSERM, UMR901, Parc Sci Luminy,BP 13, F-13273 Marseille 09, France.
EM damien.sanlaville@chu-lyon.fr; szepetowski@inmed.univ-mrs.fr
RI sanlaville, damien/M-4716-2014
OI sanlaville, damien/0000-0001-9939-2849
FU ANR (Agence Nationale de la Recherche) grant 'EPILAND'; National PHRC
grant [03-08]; INSERM (Institut National de la Sante et de la Recherche
Medicale)
FX We thank all the patients and families who participated in the study. We
thank Dr. A. Michel, Dr. L Lion-Francois, and Pr. V Des Portes for help
in patient collection and phenotyping. We thank Raphaelle Lamy for
expert technical assistance. Assistance from the Biological Resource
Centre, Hospices Civils, Lyon, France, was greatly appreciated. This
work was supported by ANR (Agence Nationale de la Recherche) grant
'EPILAND', by National PHRC grant 2010 No 03-08, and by INSERM (Institut
National de la Sante et de la Recherche Medicale).
CR Anney R, 2010, HUM MOL GENET, V19, P4072, DOI 10.1093/hmg/ddq307
Arzimanoglou A, 2004, AICARDIS EPILEPSY CH, P176
Billard C, 2009, EPILEPSIA, V50, P21, DOI 10.1111/j.1528-1167.2009.02213.x
Boutry-Kryza N, 2011, AM J MED GENET A, V158, P400
Bucan M, 2009, PLOS GENET, V5, DOI 10.1371/journal.pgen.1000536
Caliebe A, 2010, EUR J MED GENET, V53, P179, DOI 10.1016/j.ejmg.2010.04.001
Chapman NH, 2011, HUM GENET, V129, P59, DOI 10.1007/s00439-010-0899-z
Connolly AM, 1999, J PEDIATR-US, V134, P607, DOI 10.1016/S0022-3476(99)70248-9
Newbury DF, 2004, AM J HUM GENET, V74, P1225
de Kovel CGF, 2010, BRAIN, V133, P23, DOI 10.1093/brain/awp262
Deonna T, 2010, BRAIN DEV-JPN, V32, P746, DOI 10.1016/j.braindev.2010.06.011
Deonna T, 2006, EPILEPSIA, V47, P79, DOI 10.1111/j.1528-1167.2006.00697.x
DEONNA TW, 1993, NEUROPEDIATRICS, V24, P83, DOI 10.1055/s-2008-1071519
De Tiege X, 2006, EPILEPSIA, V47, P1723, DOI 10.1111/j.1528-1167.2006.00644.x
Doose H, 1996, NEUROPEDIATRICS, V27, P227, DOI 10.1055/s-2007-973771
Durand CM, 2007, NAT GENET, V39, P25, DOI 10.1038/ng1933
Endele S, 2010, NAT GENET, V42, P1021, DOI 10.1038/ng.677
Fejerman N, 2009, EPILEPSIA, V50, P9, DOI 10.1111/j.1528-1167.2009.02210.x
Feuk L, 2006, NAT REV GENET, V7, P85, DOI 10.1038/nrg1767
Giorda R, 2009, AM J HUM GENET, V85, P394, DOI 10.1016/j.ajhg.2009.08.001
Gobbi G, 2006, EPILEPSIA, V47, P62, DOI 10.1111/j.1528-1167.2006.00693.x
Helbig I, 2009, NAT GENET, V41, P160, DOI 10.1038/ng.292
Henneke M, 2009, NAT GENET, V41, P773, DOI 10.1038/ng.398
Huppke P, 2005, NEUROLOGY, V64, P1660, DOI 10.1212/01.WNL.0000160386.79347.4A
Kariminejad R, 2011, HUM MUTAT, V32, P1427, DOI 10.1002/humu.21585
Kevelam SHG, 2011, J CHILD NEUROL, V27, P178
Klauck SM, 2006, MOL PSYCHIATR, V11, P1073, DOI 10.1038/sj.mp.4001883
Kwasnicka-Crawford DA, 2005, GENOMICS, V86, P182, DOI 10.1016/j.ygeno.2005.04.002
Lancaster E, 2011, ANN NEUROL, V69, P303, DOI 10.1002/ana.22297
Landau VW, 1957, NEUROLOGY, V7, P523
Lee JA, 2006, NEURON, V52, P103, DOI 10.1016/j.neuron.2006.09.027
Li H, 2005, BRAIN DEV-JPN, V27, P207, DOI 10.1016/j.braindev.2004.06.002
Lupski JR, 2007, NAT GENET, V39, pS43, DOI 10.1038/ng2084
Ma DQ, 2009, ANN HUM GENET, V73, P263, DOI 10.1111/j.1469-1809.2009.00523.x
Mefford HC, 2010, GENOME MED, V2, DOI 10.1186/gm192
Mefford HC, 2011, ANN NEUROL, V70, P974, DOI 10.1002/ana.22645
Miyashita A, 2007, HUM MOL GENET, V16, P2854, DOI 10.1093/hmg/ddm244
Mulley JC, 2011, EPILEPSIA, V52, P423, DOI 10.1111/j.1528-1167.2010.02932.x
NAKANO S, 1989, BRAIN DEV-JPN, V11, P43
Neubauer BA, 1998, NEUROLOGY, V51, P1608
NEVSIMALOVA S, 1992, BRAIN DEV-JPN, V14, P342
Nieuwenhuis L, 2006, SEIZURE, V15, P245
Parmeggiani A, 2010, BRAIN DEV-JPN, V32, P783, DOI 10.1016/j.braindev.2010.07.003
PATRY G, 1971, ARCH NEUROL-CHICAGO, V24, P242
Penagarikano O, 2011, CELL, V147, P235, DOI 10.1016/j.cell.2011.08.040
Pinto D, 2010, NATURE, V466, P368, DOI 10.1038/nature09146
Reutlinger C, 2010, EPILEPSIA, V51, P1870, DOI 10.1111/j.1528-1167.2010.02555.x
Roll P, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0013750
Roll P, 2010, HUM MOL GENET, V19, P4848, DOI 10.1093/hmg/ddq415
Roll P, 2006, HUM MOL GENET, V15, P1195, DOI 10.1093/hmg/ddl035
Rudolf G, 2009, EPILEPSIA, V50, P25, DOI 10.1111/j.1528-1167.2009.02214.x
Sakai Y, 2011, SCI TRANSL MED, V3, DOI 10.1126/scitranslmed.3002166
SCHEFFER IE, 1995, ANN NEUROL, V38, P633, DOI 10.1002/ana.410380412
Scheltens-de Boer M, 2009, EPILIPSIA, V50, pS13
Scott-Van Zeeland AA, 2010, SCI TRANSL MED, V2, DOI 10.1126/scitranslmed.3001344
Strug LJ, 2009, EUR J HUM GENET, V17, P1171, DOI 10.1038/ejhg.2008.267
Tassinari CA, 2002, CURR PROB E, V17, P265
Toro R, 2010, TRENDS GENET, V26, P363, DOI 10.1016/j.tig.2010.05.007
Tuchman R, 2009, EPILEPSIA, V50, P18, DOI 10.1111/j.1528-1167.2009.02212.x
Van Hirtum-Das M, 2006, EPILEPSY RES, V70, pS248, DOI 10.1016/j.eplepsyres.2006.01.020
Vernes SC, 2008, NEW ENGL J MED, V359, P2337, DOI 10.1056/NEJMoa0802828
Voineagu I, 2011, NATURE, V474, P380, DOI 10.1038/nature10110
Vorstman JAS, 2011, MOL PSYCHIATR, V16, P442, DOI 10.1038/mp.2010.26
Wang K, 2009, NATURE, V459, P528, DOI 10.1038/nature07999
Wang K, 2011, MOL PSYCHIATR, V16, P949, DOI 10.1038/mp.2010.107
Wassink TH, 2002, AM J MED GENET, V114, P566, DOI 10.1002/ajmg.10415
Yoo AS, 2011, NATURE, V476, P228, DOI 10.1038/nature10323
Zhang B, 2005, NUCLEIC ACIDS RES, V33, pW741, DOI 10.1093/nar/gki475
Zhao YJ, 2010, PSYCHIAT CLIN NEUROS, V64, P565, DOI 10.1111/j.1440-1819.2010.02123.x
NR 69
TC 28
Z9 29
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0013-9580
J9 EPILEPSIA
JI Epilepsia
PD SEP
PY 2012
VL 53
IS 9
BP 1526
EP 1538
DI 10.1111/j.1528-1167.2012.03559.x
PG 13
WC Clinical Neurology
SC Neurosciences & Neurology
GA 001EJ
UT WOS:000308442900009
PM 22738016
ER
PT J
AU Mostafa, GA
Al-Ayadhi, LY
AF Mostafa, Gehan Ahmed
Al-Ayadhi, Laila Yousef
TI The relationship between the increased frequency of serum antineuronal
antibodies and the severity of autism in children
SO EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY
LA English
DT Article
DE Antineuronal antibodies; Autism; Autoimmunity; Childhood Autism Rating
scale
ID REGULATORY T-CELLS; SYSTEMIC-LUPUS-ERYTHEMATOSUS; BASIC-PROTEIN; NULL
ALLELE; AUTOANTIBODIES; AUTOIMMUNITY; ASSOCIATION; RESISTANCE;
NEUROPATHY; DISORDERS
AB Background: Autism may involve an autoimmune pathogenesis. Immunotherapy may have a role in autistic children who have brain auto-antibodies.
Aim: This study aimed to investigate the frequency of serum antineuronal auto-antibodies, as indicators of the presence of autoimmunity to brain, in a group of autistic children. We are the first to measure the relationship between these antibodies and the degree of the severity of autism.
Methods: Serum antineuronal antibodies were measured, by indirect immunofluorescence technique, in 80 autistic children, aged between 6 and 12 years, in comparison to 80 healthy-matched children. The severity of autism was assessed by using the Childhood Autism Rating Scale.
Results: Autistic children had significantly higher percent positivity of serum antineuronal antibodies (62.5%) than healthy controls (5%), P < 0.001. The frequency of the positivity of serum antineuronal antibodies was significantly higher in children with severe autism (87.5%) than children with mild to moderate autism (25%), P < 0.001. Similarly, the frequency of the positivity of these antibodies was significantly higher in female children with autism (90%) than male autistic children (53.3%), P = 0.001.
Conclusions: Serum antineuronal antibodies were found in a subgroup of autistic children and they were significantly correlated to the severity of autism. Thus, autism may be, in part, one of the pediatric autoimmune neuropsychiatric disorders. Further wide-scale studies are warranted to shed light on the etiopathogenic role of antineuronal antibodies in autism. The role of immunotherapy in autistic patients, who are seropositive for antineuronal antibodies, should also be studied. (c) 2011 European Paediatric Neurology Society. Published by Elsevier Ltd. All rights reserved.
C1 [Mostafa, Gehan Ahmed; Al-Ayadhi, Laila Yousef] King Saud Univ, Autism Res & Treatment Ctr, AL Amodi Autism Res Chair, Dept Physiol,Fac Med, Riyadh, Saudi Arabia.
[Mostafa, Gehan Ahmed] Ain Shams Univ, Dept Pediat, Fac Med, Cairo, Egypt.
RP Mostafa, GA (reprint author), 9 Ahmed El Samman St Makram Ebaid, Cairo 11511, Egypt.
EM hafezg@softhome.net
FU King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia;
NPST; Health Research and Studies program at Kind Saud University
FX This work was financially supported by the King Abdulaziz City for
Science and Technology, Riyadh, Saudi Arabia. It was also supported by
NPST, Health Research and Studies program at Kind Saud University.
CR Al-Ayadhi LY, 2011, BRAIN BEHAV IMMUN, V25, P393
Al-Ayadhi LY, 2011, J NEUROINFLAMM, V8, DOI 10.1186/1742-2094-8-111
American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th
Benedetti L, 2007, J PERIPHER NERV SYST, V12, P102, DOI 10.1111/j.1529-8027.2007.00129.x
Boris N. W., 2004, NELSON TXB PEDIAT, P93
Cohly HHP, 2005, INT REV NEUROBIOL, V71, P317, DOI 10.1016/S0074-7742(05)71013-8
Cojocaru Inimioara Mihaela, 2010, Rom J Intern Med, V48, P267
Comi AM, 1999, J CHILD NEUROL, V14, P388, DOI 10.1177/088307389901400608
CONDOM E, 1993, VIRCHOWS ARCH A, V423, P507, DOI 10.1007/BF01606543
Dochniak MJ, 2007, MED HYPOTHESES, V69, P545, DOI 10.1016/j.mehy.2007.01.060
Enstrom AM, 2009, CURR OPIN INVEST DR, V10, P463
Greenwood DLV, 2002, AUTOIMMUNITY, V35, P79, DOI 10.1080/08916930290016547
Huizinga R, 2008, TRENDS IMMUNOL, V29, P54, DOI 10.1016/j.it.2007.11.002
Javeed A, 2008, MOL DIAGN THER, V12, P171
Jyonouchi H, 2002, NEUROPSYCHOBIOLOGY, V46, P76, DOI 10.1159/000065416
Kannan S, 2005, MED HYPOTHESES, V64, P882, DOI 10.1016/j.mehy.2004.11.006
Matarazzo Eneida B, 2002, World J Biol Psychiatry, V3, P162, DOI 10.3109/15622970209150618
Mostafa GA, 2011, J NEUROINFLAMM, V8, DOI 10.1186/1742-2094-8-39
Mostafa GA, 2009, PEDIATR NEUROL, V40, P7
Mostafa GA, 2009, PEDIATR ALLERGY IMMU, V20, P192, DOI 10.1111/j.1399-3038.2008.00753.x
Mostafa GA, 2008, J CHILD NEUROL, V23, P1413, DOI 10.1177/0883073808319321
Mostafa GA, 2011, J NEUROINFLAMM, V8, DOI 10.1186/1742-2094-8-71
Mostafa GA, 2010, J NEUROIMMUNOL, V223, P115, DOI 10.1016/j.jneuroim.2010.03.025
Mostafa GA, 2010, J CHILD NEUROL, V25, P328, DOI 10.1177/0883073809339393
Mostafa GA, 2010, J NEUROIMMUNOL, V219, P114, DOI 10.1016/j.jneuroim.2009.12.003
Mutter J, 2005, NEUROENDOCRINOL LETT, V26, P439
Odell D, 2005, HUM IMMUNOL, V66, P140, DOI 10.1016/j.humimm.2004.11.002
Renaud S, 2006, NEUROLOGY, V66, P742, DOI 10.1212/01.wnl.0000201193.00382.b3
Sakaguchi S, 2004, ANNU REV IMMUNOL, V22, P531, DOI 10.1146/annurev.immunol.21.120601.141122
Schopler E., 1986, CHILDHOOD AUTISM RAT
Sheikh Z, 2007, AUTOIMMUNITY, V40, P512, DOI 10.1080/08916930701574331
SINGH VK, 1993, BRAIN BEHAV IMMUN, V7, P97, DOI 10.1006/brbi.1993.1010
Singh VK, 1997, PEDIATR NEUROL, V17, P88, DOI 10.1016/S0887-8994(97)00045-3
Singh VK, 1998, CLIN IMMUNOL IMMUNOP, V89, P105, DOI 10.1006/clin.1998.4588
Singh VK, 2004, NEUROSCI LETT, V355, P53, DOI 10.1016/j.neulet.2003.10.026
Steck AJ, 2006, CURR OPIN NEUROL, V19, P458, DOI 10.1097/01.wco.0000245368.36576.0d
Sweeten T.L., 2003, PEDIATRICS, V112, P420
Vignali DAA, 2008, NAT REV IMMUNOL, V8, P523, DOI 10.1038/nri2343
Vojdani A, 2003, INT J IMMUNOPATH PH, V16, P189
Wang GD, 2008, FREE RADICAL BIO MED, V44, P1475, DOI 10.1016/j.freeradbiomed.2008.01.012
WARREN RP, 1991, CLIN EXP IMMUNOL, V83, P438
NR 41
TC 14
Z9 14
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1090-3798
J9 EUR J PAEDIATR NEURO
JI Eur. J. Paediatr. Neurol.
PD SEP
PY 2012
VL 16
IS 5
BP 464
EP 468
DI 10.1016/j.ejpn.2011.12.010
PG 5
WC Clinical Neurology; Pediatrics
SC Neurosciences & Neurology; Pediatrics
GA 000KD
UT WOS:000308384300008
PM 22226851
ER
PT J
AU Konstantynowicz, J
Porowski, T
Zoch-Zwierz, W
Wasilewska, J
Kadziela-Olech, H
Kulak, W
Owens, SC
Piotrowska-Jastrzebska, J
Kaczmarski, M
AF Konstantynowicz, Jerzy
Porowski, Tadeusz
Zoch-Zwierz, Walentyna
Wasilewska, Jolanta
Kadziela-Olech, Halina
Kulak, Wojciech
Owens, Susan Costen
Piotrowska-Jastrzebska, Janina
Kaczmarski, Maciej
TI A potential pathogenic role of oxalate in autism
SO EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY
LA English
DT Article
DE Childhood autism; Autism spectrum disorders; Hyperoxalemia; Oxalate
ID PERVASIVE DEVELOPMENTAL DISORDERS; SPECTRUM DISORDERS; CALCIUM-OXALATE;
GASTROINTESTINAL SYMPTOMS; YOUNG-CHILDREN; EXCRETION; CRYSTALLIZATION;
NEPHROLITHIASIS; RISK; SUSCEPTIBILITY
AB Background: Although autistic spectrum disorders (ASD) are a strongly genetic condition certain metabolic disturbances may contribute to clinical features. Metabolism of oxalate in children with ASD has not yet been studied.
Aim: The objective was to determine oxalate levels in plasma and urine in autistic children in relation to other urinary parameters.
Method: In this cross-sectional study, plasma oxalate (using enzymatic method with oxalate oxidase) and spontaneous urinary calcium oxalate (CaOx) crystallization (based on the Bonn-Risk-Index, BRI) were determined in 36 children and adolescents with ASD (26 boys, 10 girls) aged 2-18 years and compared with 60 healthy non-autistic children matched by age, gender and anthropometric traits.
Results: Children with ASD demonstrated 3-fold greater plasma oxalate levels [5.60 (5th-95th percentile: 3.47-7.51)] compared with reference [(1.84 (5th-95th percentile: 0.50-4.70) mu mol/L ( p < 0.05)] and 2.5-fold greater urinary oxalate concentrations ( p < 0.05). No differences between the two groups were found in urinary pH, citraturia, calciuria or adjusted CaOx crystallization rates based on BRI. Despite significant hyperoxaluria no evidence of kidney stone disease or lithogenic risk was observed in these individuals.
Conclusions: Hyperoxalemia and hyperoxaluria may be involved in the pathogenesis of ASD in children. Whether this is a result of impaired renal excretion or an extensive intestinal absorption, or both, or whether Ox may cross the blood brain barrier and disturb CNS function in the autistic children remains unclear. This appears to be the first report of plasma and urinary oxalate in childhood autism. (c) 2011 European Paediatric Neurology Society. Published by Elsevier Ltd. All rights reserved.
C1 [Konstantynowicz, Jerzy; Kadziela-Olech, Halina; Piotrowska-Jastrzebska, Janina] Med Univ Bialystok, Dept Pediat & Dev Disorders, PL-15274 Bialystok, Poland.
[Porowski, Tadeusz; Zoch-Zwierz, Walentyna] Med Univ Bialystok, Dept Pediat & Nephrol, PL-15274 Bialystok, Poland.
[Wasilewska, Jolanta; Kaczmarski, Maciej] Med Univ Bialystok, Dept Pediat Gastroenterol & Allergol, PL-15274 Bialystok, Poland.
[Kulak, Wojciech] Med Univ Bialystok, Dept Pediat Rehabil, PL-15274 Bialystok, Poland.
[Owens, Susan Costen] Autism Res Inst, Autism Oxalate Project, San Diego, CA USA.
RP Konstantynowicz, J (reprint author), Med Univ Bialystok, Dr L Zamenhof Childrens Teaching Hosp, Dept Pediat & Dev Disorders, 17 Waszyngtona Str, PL-15274 Bialystok, Poland.
EM jurekonstant@o2.pl
CR Adams JB, 2006, J ALTERN COMPLEM MED, V12, P59, DOI 10.1089/acm.2006.12.59
Alberti A, 1999, BIOL PSYCHIAT, V46, P420, DOI 10.1016/S0006-3223(98)00337-0
Alcorn A, 2004, J INTELL DISABIL RES, V48, P274, DOI 10.1111/j.1365-2788.2003.00554.x
Baird G, 2006, LANCET, V368, P210, DOI 10.1016/S0140-6736(06)69041-7
Bauman ML, 2005, INT J DEV NEUROSCI, V23, P183, DOI 10.1016/j.ijdevneu.2004.09.006
Bilder D, 2009, PEDIATRICS, V123, P1293, DOI 10.1542/peds.2008-0927
BUTTNER T, 1987, NERVENARZT, V58, P181
Casanova MF, 2002, NEUROLOGY, V58, P428
Croonenberghs J, 2000, NEUROPSYCHOPHARMACOL, V22, P275, DOI 10.1016/S0893-133X(99)00131-1
DAUDON M, 1995, UROL RES, V23, P319
Dawson G, 1996, J AUTISM DEV DISORD, V26, P179, DOI 10.1007/BF02172008
Evans C, 2008, NUTR NEUROSCI, V11, P9, DOI 10.1179/147683008X301360
Fombonne E, 2005, J CLIN PSYCHIAT, V66, P3
Hatch M, 2008, SEMIN NEPHROL, V28, P143, DOI 10.1016/j.semnephrol.2008.01.007
Hatch M, 2003, AM J NEPHROL, V23, P18, DOI 10.1159/000066300
Holmes RP, 1998, J UROLOGY, V160, P1617, DOI 10.1016/S0022-5347(01)62363-2
James SJ, 2009, FASEB J
Jyonouchi H, 2005, J PEDIATR-US, V146, P605, DOI 10.1016/j.peds.2005.01.027
Jyonouchi H, 2009, CURR ALLERGY ASTHM R, V9, P194, DOI 10.1007/s11882-009-0029-y
Jyonouchi H, 2005, NEUROPSYCHOBIOLOGY, V51, P77, DOI 10.1159/000084164
Kim SJ, 2008, AM J MED GENET B, V147B, P1116, DOI 10.1002/ajmg.b.30733
Kunachowicz H, 1998, FOOD COMPOSITION TAB
Lainhart JE, 2002, AM J MED GENET, V113, P231, DOI 10.1002/ajmg.10615
Laube N, 2000, UROL RES, V28, P274
Laube N, 2002, CLIN CHEM LAB MED, V40, P595, DOI 10.1515/CCLM.2002.102
Linster CL, 2007, FEBS J, V274, P1, DOI 10.1111/j.1742-4658.2006.05607.x
Liu JJ, 2001, AM J HUM GENET, V69, P327, DOI 10.1086/321980
Manzi B, 2008, J CHILD NEUROL, V23, P307, DOI 10.1177/0883073807308698
Markovich D, 2007, ANNU REV PHYSIOL, V69, P361, DOI 10.1146/annurev.physiol.69.040705.141319
Ming X, 2005, PROSTAG LEUKOTR ESS, V73, P379, DOI 10.1016/j.plefa.2005.06.002
Monico CG, 2008, AM J KIDNEY DIS, V52, P1096, DOI 10.1053/j.ajkd.2008.07.041
Murch S, 2005, J PEDIATR-US, V146, P582, DOI 10.1016/j.jpeds.2005.02.026
Nataf R, 2006, TOXICOL APPL PHARM, V214, P99, DOI 10.1016/j.taap.2006.04.008
Palmen SJMC, 2004, BRAIN, V127, P2572, DOI 10.1093/brain/awh287
PEIFFER J, 1984, CLIN NEUROPATHOL, V3, P76
Porowski T, 2007, PEDIATR NEPHROL, V22, P514, DOI 10.1007/s00467-006-0383-0
Porowski Tadeusz, 2003, Acta Pol Pharm, V60, P239
Porowski T, 2008, PEDIATR NEPHROL, V23, P1787, DOI 10.1007/s00467-008-0889-8
Rapin I, 1998, ANN NEUROL, V43, P7, DOI 10.1002/ana.410430106
Robertson WG, 1999, KIDNEY STONES, P33
Rumsby G, 2008, AM J KIDNEY DIS, V52, P1031, DOI 10.1053/j.ajkd.2008.10.004
Sakhaee K, 2009, KIDNEY INT, V75, P585, DOI 10.1038/ki.2008.626
Smeeth L, 2002, LANCET, V359, P2112, DOI 10.1016/S0140-6736(02)08918-3
Soleimani M, 2008, J PHYSIOL-LONDON, V586, P1205, DOI 10.1113/jphysiol.2007.150565
Sparks BF, 2002, NEUROLOGY, V59, P184
Stapleton FB, 2002, ENDOCRIN METAB CLIN, V31, P1001, DOI 10.1016/S0889-8529(02)00036-1
Steyaert JG, 2008, EUR J PEDIATR, V167, P1091, DOI 10.1007/s00431-008-0764-4
Takahashi S, 2008, LEGAL MED-TOKYO, V10, P43
Tordjman S, 2005, BIOL PSYCHIAT, V57, P134, DOI 10.1016/j.biopsych.2004.11.003
Tsao CY, 2007, J CHILD NEUROL, V22, P1121, DOI 10.1177/0883073807306266
Volkmar FR, 2003, LANCET, V362, P1133, DOI 10.1016/S0140-6736(03)14471-6
Wakefield AJ, 2005, EUR J GASTROEN HEPAT, V17, P827, DOI 10.1097/00042737-200508000-00009
Walker-Smith J, 2002, LANCET, V359, P705, DOI 10.1016/S0140-6736(02)07783-8
Waring R. H., 2000, Journal of Nutritional and Environmental Medicine (Abingdon), V10, P25, DOI 10.1080/13590840050000861
Whiteley P, 2006, PEDIATR INT, V48, P292, DOI 10.1111/j.1442-200X.2006.02207.x
WHO, 1993, ICD 10 CLASS MENT BE
NR 56
TC 3
Z9 3
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1090-3798
J9 EUR J PAEDIATR NEURO
JI Eur. J. Paediatr. Neurol.
PD SEP
PY 2012
VL 16
IS 5
BP 485
EP 491
DI 10.1016/j.ejpn.2011.08.004
PG 7
WC Clinical Neurology; Pediatrics
SC Neurosciences & Neurology; Pediatrics
GA 000KD
UT WOS:000308384300011
PM 21911305
ER
PT J
AU Macedoni-Luksic, M
AF Macedoni-Luksic, Marta
TI Biochemical markers in autism spectrum disorders
SO EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY
LA English
DT Meeting Abstract
DE autism; biochemical markers
C1 [Macedoni-Luksic, Marta] Univ Med Ctr Ljubljana, Univ Childrens Hosp, Dept Child Adolescent & Dev Neurol, Ljubljana, Slovenia.
NR 0
TC 0
Z9 0
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1090-3798
J9 EUR J PAEDIATR NEURO
JI Eur. J. Paediatr. Neurol.
PD SEP
PY 2012
VL 16
IS 5
BP 557
EP 557
PG 1
WC Clinical Neurology; Pediatrics
SC Neurosciences & Neurology; Pediatrics
GA 000KD
UT WOS:000308384300023
ER
PT J
AU Garcia-Penas, JJ
Dominguez-Carral, J
AF Jose Garcia-Penas, Juan
Dominguez-Carral, Jana
TI Association of Autism Spectrum Disorders, Epilepsy, and Temporal Lobe
Pathology
SO EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY
LA English
DT Meeting Abstract
DE autism spectrum disorders; autistic regression; epilepsy; temporal lobe
C1 [Jose Garcia-Penas, Juan; Dominguez-Carral, Jana] Hosp Univ Marques de Valdecilla, Santander, Cantabria, Spain.
NR 0
TC 0
Z9 0
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1090-3798
J9 EUR J PAEDIATR NEURO
JI Eur. J. Paediatr. Neurol.
PD SEP
PY 2012
VL 16
IS 5
BP 560
EP 560
PG 1
WC Clinical Neurology; Pediatrics
SC Neurosciences & Neurology; Pediatrics
GA 000KD
UT WOS:000308384300033
ER
PT J
AU Lerna, A
Esposito, D
Conson, M
Russo, L
Massagli, A
AF Lerna, Anna
Esposito, Dalila
Conson, Massimiliano
Russo, Luigi
Massagli, Angelo
TI Social-communicative effects of the Picture Exchange Communication
System (PECS) in Autism Spectrum Disorders
SO INTERNATIONAL JOURNAL OF LANGUAGE & COMMUNICATION DISORDERS
LA English
DT Article
DE Picture Exchange Communication System (PECS); autism; intervention;
social and communicative skills
ID CHILDREN; INTERVENTION; TEACHERS; SPEECH; SKILLS
AB Background: The Picture Exchange Communication System (PECS) is a common treatment choice for non-verbal children with autism. However, little empirical evidence is available on the usefulness of PECS in treating socialcommunication impairments in autism. Aims: To test the effects of PECS on socialcommunicative skills in children with autism, concurrently taking into account standardized psychometric data, standardized functional assessment of adaptive behaviour, and information on socialcommunicative variables coded in an unstructured setting. Methods & Procedures: Eighteen preschool children (mean age = 38.78 months) were assigned to two intervention approaches, i.e. PECS and Conventional Language Therapy (CLT). Both PECS (Phases IIV) and CLT were delivered three times per week, in 30-min sessions, for 6 months. Outcome measures were the following: Autism Diagnostic Observation Schedule (ADOS) domain scores for Communication and Reciprocal Social Interaction; Language and PersonalSocial subscales of the Griffiths Mental Developmental Scales (GMDS); Communication and Social Abilities domains of the Vineland Adaptive Behavior Scales (VABS); and several socialcommunicative variables coded in an unstructured setting. Outcomes & Results: Results demonstrated that the two groups did not differ at Time 1 (pre-treatment assessment), whereas at Time 2 (post-test) the PECS group showed a significant improvement with respect to the CLT group on the VABS social domain score and on almost all the socialcommunicative abilities coded in the unstructured setting (i.e. joint attention, request, initiation, cooperative play, but not eye contact). Conclusions & Implications: These findings showed that PECS intervention (Phases IIV) can improve socialcommunicative skills in children with autism. This improvement is especially evident in standardized measures of adaptive behaviour and measures derived from the observation of children in an unstructured setting.
C1 [Lerna, Anna; Esposito, Dalila; Russo, Luigi; Massagli, Angelo] Sci Inst IRCCS Eugenio Medea Reg Branch Ostuni, Brindisi Dept Neurorehabil 2, Brindisi, Italy.
[Conson, Massimiliano] Univ Naples 2, Neuropsychol Lab, Dept Psychol, Caserta, Italy.
RP Massagli, A (reprint author), Child Psychiat Sci Inst IRCCS Eugenio Medea, Dept Neurorehabil 2, Reg Branch Ostuni Brindisi, Di Summa Sq, I-72100 Brindisi, Italy.
EM angelo.massagli@os.lnf.it
CR (APA) APA, 2000, DIAGN STAT MAN MENT
BONDY A. S., 1994, PECS PICTURE EXCHANG
Bondy Andrew S., 1998, Seminars in Speech and Language, V19, P373, DOI 10.1055/s-2008-1064055
Carr D, 2007, J AUTISM DEV DISORD, V37, P724, DOI 10.1007/s10803-006-0203-1
Charlop-Christy MH, 2002, J APPL BEHAV ANAL, V35, P213, DOI 10.1901/jaba.2002.35-213
Fenson L, 1993, MACARTHUR COMMUNICAT
Flippin M, 2010, AM J SPEECH-LANG PAT, V19, P178, DOI 10.1044/1058-0360(2010/09-0022)
Frost L, 2002, PECS PICTURE EXCHANG
Ganz J. B., 2011, J AUTISM DEV DISORD, V42, P60, DOI [10.1007/s10803-011-1212-2, DOI 10.1007/S10803-011-1212-2]
Goldstein H, 2002, J AUTISM DEV DISORD, V32, P373, DOI 10.1023/A:1020589821992
Gordon K, 2011, J CONSULT CLIN PSYCH, V79, P447, DOI 10.1037/a0024379
Griffiths R., 1984, GRIFFITHS MENTAL DEV
Howlin P., 1998, TREATING CHILDREN AU
Howlin P, 2007, J CHILD PSYCHOL PSYC, V48, P473, DOI 10.1111/j.1469-7610.2006.01707.x
Howlin P, 2004, J CHILD PSYCHOL PSYC, V45, P212, DOI 10.1111/j.1469-7610.2004.00215.x
Klin A, 2007, J AUTISM DEV DISORD, V37, P748, DOI 10.1007/s10803-006-0229-4
Kravits TR, 2002, J AUTISM DEV DISORD, V32, P225, DOI 10.1023/A:1015457931788
Lord C., 1999, AUTISM DIAGNOSTIC OB
Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
Lovaas O. I., 1981, TEACHING DEV DISABLE
LOVAAS O. I., 2002, TEACHING INDIVIDUALS
Mesibov G., 2004, TEACCH APPROACH AUTI
Mirenda P, 2003, LANG SPEECH HEAR SER, V34, P203, DOI 10.1044/0161-1461(2003/017)
Mundy P, 2003, J CHILD PSYCHOL PSYC, V44, P793, DOI 10.1111/1469-7610.00165
Mundy P, 2000, DEV PSYCHOBIOL, V36, P325, DOI 10.1002/(SICI)1098-2302(200005)36:4<325::AID-DEV7>3.0.CO;2-F
MUNDY P, 1992, INFANT BEHAV DEV, V15, P377, DOI 10.1016/0163-6383(92)80006-G
Noldus Information Technology, 2007, OBS XT 2007
Preston D, 2009, J AUTISM DEV DISORD, V39, P1471, DOI 10.1007/s10803-009-0763-y
Schuler A. L., 1997, HDB AUTISM PERVASIVE, P539
Sparrow SS, 2005, VINELAND ADAPTIVE BE
Tomasello M, 2007, CHILD DEV, V78, P705, DOI 10.1111/j.1467-8624.2007.01025.x
WATSON L. R., 1989, TEACHING SPONTANEOUS
Yoder P, 2006, J CONSULT CLIN PSYCH, V74, P426, DOI 10.1037/0022-006X.74.3.426
NR 33
TC 3
Z9 4
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1368-2822
J9 INT J LANG COMM DIS
JI Int. J. Lang. Commun. Disord.
PD SEP-OCT
PY 2012
VL 47
IS 5
BP 609
EP 617
DI 10.1111/j.1460-6984.2012.00172.x
PG 9
WC Audiology & Speech-Language Pathology; Linguistics; Rehabilitation
SC Audiology & Speech-Language Pathology; Linguistics; Rehabilitation
GA 999DZ
UT WOS:000308290900013
PM 22938071
ER
PT J
AU Assouline, SG
Nicpon, MF
Dockery, L
AF Assouline, Susan G.
Nicpon, Megan Foley
Dockery, Lori
TI Predicting the Academic Achievement of Gifted Students with Autism
Spectrum Disorder
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism; Cognitive ability; Academic achievement; Gifted
ID WRITTEN LANGUAGE PRODUCTION; WORKING-MEMORY; PROCESSING SPEED; CHILDREN;
ABILITY
AB We are not well informed regarding the ability-achievement relationship for twice-exceptional individuals (very high cognitive ability and a diagnosed disability, e.g., autism spectrum disorder [ASD]). The research question for this investigation (N = 59) focused on the predictability of achievement among variables related to ability and education in a twice-exceptional sample of students (cognitive ability of 120 [91st percentile], or above, and diagnosed with ASD). We determined that WISC-IV Working Memory and Processing Speed Indices were both significantly positively correlated with achievement in math, reading, and written language. WISC Perceptual Reasoning Index was uniquely predictive of Oral Language test scores. Unexpected findings were that ASD diagnosis, Verbal Comprehension Index, and forms of academic acceleration were not related to the dependent variables.
C1 [Assouline, Susan G.; Nicpon, Megan Foley; Dockery, Lori] Univ Iowa, Dept Quantitat & Psychol Fdn, Coll Educ, Blank Honors Ctr 600, Iowa City, IA 52242 USA.
RP Assouline, SG (reprint author), Univ Iowa, Dept Quantitat & Psychol Fdn, Coll Educ, Blank Honors Ctr 600, Iowa City, IA 52242 USA.
EM susan-assouline@uiowa.edu
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
Asperger H., 1991, AUTISM ASPERGER SYND
Assouline S. G., 2007, NAGC COMMUNIQUE SPR, P9
Assouline SG, 2009, GIFTED CHILD QUART, V53, P89, DOI 10.1177/0016986208330565
Beery K. E., 2004, BERRY VMI ADM SCORIN
Beery K. E., 2004, BEERY BUKTENICA DEV
BOURDIN B, 1994, INT J PSYCHOL, V29, P591, DOI 10.1080/00207599408248175
Calhoun SL, 2005, PSYCHOL SCHOOLS, V42, P333, DOI 10.1002/pits.20067
Carretti B, 2009, LEARN INDIVID DIFFER, V19, P246, DOI 10.1016/j.lindif.2008.10.002
Catts H. W., 2002, J LEARN DISABIL, V35, P510, DOI DOI 10.1177/00222194020350060301
Colangelo N., 2004, NATION DECEIVED SCH
Eaves LC, 1997, J DEV PHYS DISABIL, V9, P277, DOI 10.1023/A:1024944226971
Estes A, 2011, J AUTISM DEV DISORD, V41, P1044, DOI 10.1007/s10803-010-1127-3
Foley Nicpon M., 2012, GIFTED CHILD Q, V56
Fuentes CT, 2009, NEUROLOGY, V73, P1532, DOI 10.1212/WNL.0b013e3181c0d48c
Harackiewicz JM, 2002, J EDUC PSYCHOL, V94, P562, DOI 10.1037//0022-0663.94.3.562
Jensen A. R., 1998, G FACTOR SCI MENTAL
Joseph RM, 2002, J CHILD PSYCHOL PSYC, V43, P807, DOI 10.1111/1469-7610.00092
Kanner L, 1943, NERV CHILD, V2, P217
Klin A., 2000, ASPERGER SYNDROME
Lord C, 2003, AUTISM DIAGNOSTIC OB
Lubinski D, 2001, J APPL PSYCHOL, V86, P718, DOI 10.1037/0021-9010.86.4.718
Mayes SD, 2003, J AUTISM DEV DISORD, V33, P329, DOI 10.1023/A:1024462719081
Mayes SD, 2007, CHILD NEUROPSYCHOL, V13, P469, DOI 10.1080/09297040601112773
Meyer J. A, 2001, ASSESSMENT EFFECTIVE, V27, P27
Myles BS, 2001, EDUC TRAIN MENT RET, V36, P304
Nicpon MF, 2011, GIFTED CHILD QUART, V55, P3, DOI 10.1177/0016986210382575
Ozonoff S, 2000, ASPERGER SYNDROME, P72
Raulerson BA, 2010, PERCEPT MOTOR SKILL, V110, P229, DOI 10.2466/PMS.110.1.229-244
Rohde TE, 2007, INTELLIGENCE, V35, P83, DOI 10.1016/j.intell.2006.05.004
Rowe EW, 2010, SCHOOL PSYCHOL QUART, V25, P119, DOI 10.1037/a0020148
Rutter M., 2003, AUTISM DIAGNOSTIC IN
Sansosti F. J., 2010, AUSISM ASPERGER SYND
Sattler J. M., 2008, ASSESSMENT CHILDREN, V5th
Stephens K. R., 2011, J APPL SCH PSYCHOL, V27, P306, DOI [10.1080/15377903.2011.615823, DOI 10.1080/15377903.2011.615823]
Swanson HL, 2009, J LEARN DISABIL-US, V42, P260, DOI 10.1177/0022219409331958
Swanson HL, 2011, COGNITIVE DEVELOPMENT AND WORKING MEMORY: A DIALOGUE BETWEEN NEO-PIAGETIAN THEORIES AND COGNITIVE APPROACHES, P203
Wechsler D., 2003, WECHSLER INTELLIGENC
Wechsler D, 1997, WECHSLER ADULT INTEL, V3rd
Witwer AN, 2008, J AUTISM DEV DISORD, V38, P1611, DOI 10.1007/s10803-008-0541-2
Woo S. M., 2008, DIAGNOSIS TREATMENT
Woodcock R. W., 2001, WOODCOCK JOHNSON 3 T
NR 42
TC 8
Z9 8
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD SEP
PY 2012
VL 42
IS 9
BP 1781
EP 1789
DI 10.1007/s10803-011-1403-x
PG 9
WC Psychology, Developmental
SC Psychology
GA 992XT
UT WOS:000307815100001
PM 22105142
ER
PT J
AU Santos, A
Chaminade, T
Da Fonseca, D
Silva, C
Rosset, D
Deruelle, C
AF Santos, Andreia
Chaminade, Thierry
Da Fonseca, David
Silva, Catarina
Rosset, Delphine
Deruelle, Christine
TI Just Another Social Scene: Evidence for Decreased Attention to Negative
Social Scenes in High-Functioning Autism
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism spectrum disorders; Threat detection advantage; Eye-tracking
ID SPECTRUM DISORDER; FACIAL EXPRESSIONS; ASPERGER-SYNDROME; EVOLUTIONARY
PERSPECTIVE; JOINT ATTENTION; EVOLVED MODULE; CROWD EVIDENCE;
EYE-MOVEMENTS; VISUAL-SEARCH; ANGRY FACES
AB The adaptive threat-detection advantage takes the form of a preferential orienting of attention to threatening scenes. In this study, we compared attention to social scenes in 15 high-functioning individuals with autism (ASD) and matched typically developing (TD) individuals. Eye-tracking was recorded while participants were presented with pairs of scenes, either emotional positive-neutral, emotional negative-neutral or neutral-neutral scenes. Early allocation of attention, the first image fixated in each pair, differed between groups: contrary to TD individuals who showed the typical threat-detection advantage towards negative images, the ASD group failed to show a bias toward threat-related scenes. Later processing of stimuli, indicated by the total fixation to the images during the 3-s presentation, was found unaffected in the ASD group. These results support the hypothesis of an early atypical allocation of attention towards natural social scenes in ASD, that is compensated in later stages of visual processing.
C1 [Santos, Andreia; Chaminade, Thierry; Da Fonseca, David; Silva, Catarina; Rosset, Delphine; Deruelle, Christine] CNRS INCM, Mediterranean Inst Cognit Neurosci, F-13402 Marseille 20, France.
[Da Fonseca, David; Rosset, Delphine] St Marguerite Hosp, Autism Resources Ctr, Marseille, France.
RP Santos, A (reprint author), CNRS INCM, Mediterranean Inst Cognit Neurosci, 31 Chemin Joseph Aiguier, F-13402 Marseille 20, France.
EM andreia.santos@incm.cnrs-mrs.fr; Deruelle@incm.cnrs-mrs.fr
RI deruelle, christine/E-2130-2015
CR American Phychiatric Assocation, 2000, DIAGN STAT MAN MENT
[Anonymous], 2008, GAZETRACKER SOFTW GU
Ashwin C, 2006, BRAIN COGNITION, V61, P78, DOI 10.1016/j.bandc.2005.12.008
Bannerman RL, 2009, P ROY SOC B-BIOL SCI, V276, P1635, DOI 10.1098/rspb.2008.1744
Blanchette I, 2006, Q J EXP PSYCHOL, V59, P1484, DOI 10.1080/02724980543000204
Boyer P, 2011, NEUROSCI BIOBEHAV R, V35, P1034, DOI 10.1016/j.neubiorev.2010.08.010
BRADLEY MM, 1994, J BEHAV THER EXP PSY, V25, P49, DOI 10.1016/0005-7916(94)90063-9
Calvo MG, 2008, EMOTION, V8, P68, DOI 10.1037/1528-3542.8.1.68
Chawarska K, 2010, ARCH GEN PSYCHIAT, V67, P178, DOI 10.1001/archgenpsychiatry.2009.194
Dawson G, 2004, DEV PSYCHOL, V40, P271, DOI 10.1037/0012-1649.40.2.271
Dawson G, 2002, CHILD DEV, V73, P700, DOI 10.1111/1467-8624.00433
Dichter GS, 2010, J AUTISM DEV DISORD, V40, P858, DOI 10.1007/s10803-009-0925-y
Eastwood JD, 2001, PERCEPT PSYCHOPHYS, V63, P1004, DOI 10.3758/BF03194519
ESTEVES F, 1994, PSYCHOPHYSIOLOGY, V31, P375, DOI 10.1111/j.1469-8986.1994.tb02446.x
Fletcher-Watson S, 2009, NEUROPSYCHOLOGIA, V47, P248, DOI 10.1016/j.neuropsychologia.2008.07.016
Fox E, 2000, COGNITION EMOTION, V14, P61
Freeth M, 2010, J AUTISM DEV DISORD, V40, P534, DOI 10.1007/s10803-009-0893-2
Gerritsen C, 2008, PERCEPT PSYCHOPHYS, V70, P1047, DOI 10.3758/PP.70.6.1047
Hahn S, 2006, ACTA PSYCHOL, V123, P312, DOI 10.1016/j.actpsy.2006.01.008
Horstmann G, 2006, EMOTION, V6, P193, DOI 10.1037/1528-3542.6.2.193
Jones W, 2008, ARCH GEN PSYCHIAT, V65, P946, DOI 10.1001/archpsyc.65.8.946
Kliemann D, 2010, J NEUROSCI, V30, P12281, DOI 10.1523/JNEUROSCI.0688-10.2010
Klin A, 2003, PHILOS T ROY SOC B, V358, P345, DOI 10.1098/rstb.2002.1202
Klin A, 2002, ARCH GEN PSYCHIAT, V59, P809, DOI 10.1001/archpsyc.59.9.809
Klin A, 2000, J CHILD PSYCHOL PSYC, V41, P831, DOI 10.1017/S0021963099006101
Krysko KM, 2009, BRAIN COGNITION, V69, P472, DOI 10.1016/j.bandc.2008.10.002
Lang P. J., 2001, A5 U FLOR CTR RES PS
LAUGHLIN S, 1981, Z NATURFORSCH C, V36, P910
Lavie N, 2004, J EXP PSYCHOL GEN, V133, P339, DOI 10.1037/0096-3445.133.3.339
Leekam SR, 2000, DEV PSYCHOL, V36, P261, DOI 10.1037/0012-1649.36.2.261
Lord C., 2000, AUTISM DIAGNOSTIC OB
New JJ, 2010, NEUROPSYCHOLOGIA, V48, P51, DOI 10.1016/j.neuropsychologia.2009.08.008
Nummenmaa L, 2006, EMOTION, V6, P257, DOI 10.1037/1528-3542.6.2.257
Ohman A., 1993, HDB EMOTIONS
Ohman A, 2001, J PERS SOC PSYCHOL, V80, P381, DOI 10.1037//0022-3514.80.3.381
Ohman A, 2003, CURR DIR PSYCHOL SCI, V12, P5, DOI 10.1111/1467-8721.01211
Ohman A, 2001, PSYCHOL REV, V108, P483, DOI 10.1037//0033-295X.108.3.483
Ohman A, 2009, SCAND J PSYCHOL, V50, P543, DOI 10.1111/j.1467-9450.2009.00784.x
Pierce K, 2011, ARCH GEN PSYCHIAT, V68, P101, DOI 10.1001/archgenpsychiatry.2010.113
Rosset D, 2011, RES AUTISM SPECT DIS, V5, P949, DOI 10.1016/j.rasd.2010.11.005
Rump KM, 2009, CHILD DEV, V80, P1434, DOI 10.1111/j.1467-8624.2009.01343.x
Rutter M., 2003, ADI R AUTISM DIAGNOS
Santos A, 2010, NEUROPSYCHOLOGIA, V48, P1071, DOI 10.1016/j.neuropsychologia.2009.12.006
Santos A, 2008, PSYCHOL SCI, V19, P70, DOI 10.1111/j.1467-9280.2008.02048.x
Senju A, 2009, SCIENCE, V325, P883, DOI 10.1126/science.1176170
Venter A., 1992, HIGH FUNCTIONING IND, P187
Vuilleumier P, 2001, NEUROLOGY, V56, P153
Waters AM, 2010, J BEHAV THER EXP PSY, V41, P158, DOI 10.1016/j.jbtep.2009.12.001
Wechsler D., 2003, MANUAL WECHSLER INTE, VFourth
Wechsler D, 1997, WECHSLER ADULT INTEL, V3rd
Wilbarger JL, 2009, NEUROPSYCHOLOGIA, V47, P1323, DOI 10.1016/j.neuropsychologia.2009.01.025
NR 51
TC 2
Z9 2
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD SEP
PY 2012
VL 42
IS 9
BP 1790
EP 1798
DI 10.1007/s10803-011-1415-6
PG 9
WC Psychology, Developmental
SC Psychology
GA 992XT
UT WOS:000307815100002
PM 22160371
ER
PT J
AU Whyatt, CP
Craig, CM
AF Whyatt, Caroline P.
Craig, Cathy M.
TI Motor Skills in Children Aged 7-10 Years, Diagnosed with Autism Spectrum
Disorder
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism; Motor control; Manual dexterity; Ball skills; Balance
ID HIGH-FUNCTIONING AUTISM; ASPERGER-SYNDROME; IMPAIRMENT; MOVEMENT;
SEVERITY
AB This study used the Movement Assessment Battery for Children (M-ABC2) to assess motor skills in children aged 7-10 years with autism (n = 18) in comparison to two groups of age-matched typically developing children; a receptive vocabulary matched group (n = 19) and a nonverbal IQ matched group (n = 22). The results supported previous work, as indicated by a significant general motor impairment in the group with autism. However, sub-analysis of the M-ABC2 revealed that there were only 2 out of 8 subcomponent skills which showed universal significant specific deficits for the autism group; i.e. catching a ball and static balance. These results suggest that motor skill deficits associated with autism may not be pervasive but more apparent in activities demanding complex, interceptive actions or core balance ability.
C1 [Whyatt, Caroline P.; Craig, Cathy M.] Queens Univ Belfast, Sch Psychol, Belfast BT9 5BN, Antrim, North Ireland.
RP Whyatt, CP (reprint author), Queens Univ Belfast, Sch Psychol, 18-30 Malone Rd, Belfast BT9 5BN, Antrim, North Ireland.
EM cwhyatt01@qub.ac.uk
RI Craig, Cathy/D-9833-2014
OI Craig, Cathy/0000-0001-5509-1120
CR Asperger H., 1991, AUTISM ASPERGER SYND, P37, DOI 10.1017/CBO9780511526770.002
Attwood T., 1998, ASPERGERS SYNDROME G
Bauman M. L., 1992, MOVEMENT DISORDERS N, P659
Bayley N, 1993, BAYLEY SCALES INFANT
Bruininks R. H., 1978, BRUININKS OSERETSKY
COLLINS JJ, 1993, EXP BRAIN RES, V95, P308
Dunn L. M., 1997, BRIT PICTURE VOCABUL, V2nd
Dziuk MA, 2007, DEV MED CHILD NEUROL, V49, P734
Faul F, 2007, BEHAV RES METHODS, V39, P175, DOI 10.3758/BRM.41.4.1149
FITTS PM, 1954, J EXP PSYCHOL, V47, P381, DOI 10.1037/h0055392
Folio M. R., 2000, PEABODY DEV MOTOR SC
Frith U., 2003, AUTISM EXPLAINING EN
Ghaziuddin M, 1998, J INTELL DISABIL RES, V42, P43, DOI 10.1046/j.1365-2788.1998.00065.x
Glazebrook CM, 2006, MOTOR CONTROL, V10, P244
Green D, 2009, DEV MED CHILD NEUROL, V51, P311, DOI 10.1111/j.1469-8749.2008.03242.x
Green D, 2002, J CHILD PSYCHOL PSYC, V43, P655, DOI 10.1111/1469-7610.00054
Henderson S, 2007, MOVEMENT ASSESSMENT, V2nd
Henderson SE, 1992, MOVEMENT ASSESSMENT
Hilton C, 2007, RES AUTISM SPECT DIS, V1, P339, DOI 10.1016/j.rasd.2006.12.003
Jansiewicz EM, 2006, J AUTISM DEV DISORD, V36, P613, DOI 10.1007/s10803-006-0109-y
Kanner L, 1943, NERV CHILD, V2, P217
Leary MR, 1996, MENT RETARD, V34, P39
MANJIVIONA J, 1995, J AUTISM DEV DISORD, V25, P23, DOI 10.1007/BF02178165
Mari M, 2003, PHILOS T ROY SOC B, V358, P393, DOI 10.1098/rstb.2002.1205
Ming X, 2007, BRAIN DEV-JPN, V29, P565, DOI 10.1016/j.braindev.2007.03.002
Miyahara M, 1997, J AUTISM DEV DISORD, V27, P595, DOI 10.1023/A:1025834211548
Provost B, 2007, J AUTISM DEV DISORD, V37, P321, DOI 10.1007/s10803-006-0170-6
Rinehart NJ, 2006, DEV MED CHILD NEUROL, V48, P272, DOI 10.1017/S0012162206000594
Staples KL, 2010, J AUTISM DEV DISORD, V40, P209, DOI 10.1007/s10803-009-0854-9
Stott DH, 1972, TEST MOTOR IMPAIRMEN
Sutera S, 2007, J AUTISM DEV DISORD, V37, P98, DOI 10.1007/s10803-006-0340-6
Teitelbaum P, 1998, P NATL ACAD SCI USA, V95, P13982, DOI 10.1073/pnas.95.23.13982
Ulrich D. A., 2000, TEST GROSS MOTOR DEV
von Hofsten C, 2007, DEVELOPMENTAL SCI, V10, P54, DOI 10.1111/j.1467-7687.2007.00564.x
Wechsler D., 2006, WECHSLER NONVERBAL S
World Health Organisation, 1992, ICD 10 CLASS MENT BE
NR 36
TC 16
Z9 16
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD SEP
PY 2012
VL 42
IS 9
BP 1799
EP 1809
DI 10.1007/s10803-011-1421-8
PG 11
WC Psychology, Developmental
SC Psychology
GA 992XT
UT WOS:000307815100003
PM 22180003
ER
PT J
AU Taheri, A
Perry, A
AF Taheri, Azin
Perry, Adrienne
TI Exploring the Proposed DSM-5 Criteria in a Clinical Sample
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE DSM-5; DSM-IV; ASD; Diagnosis
ID AUTISM SPECTRUM DISORDER; DIAGNOSTIC-OBSERVATION-SCHEDULE; REVISED
ALGORITHMS; IV-TR; VALIDITY
AB The proposed DSM-5 criteria for Autism Spectrum Disorder (ASD) depart substantially from the previous DSM-IV criteria. In this file review study of 131 children aged 2-12, previously diagnosed with either Autistic Disorder or Pervasive Developmental Disorder-Not Otherwise Specified (PDD-NOS), 63 % met the new DSM-5 ASD criteria, including 81 % previously diagnosed with Autistic Disorder and only 17 % of those with PDD-NOS. The proportion of children meeting DSM-5 differed by IQ grouping as well, with higher rates in lower IQ groups. Children who did meet criteria for ASD had significantly lower levels of cognitive and adaptive skills and greater autism severity but were similar in age. These findings raise concerns that the new DSM-5 criteria may miss a number of children who would currently receive a diagnosis.
C1 [Taheri, Azin; Perry, Adrienne] York Univ, Dept Psychol, N York, ON M3J 1P3, Canada.
RP Perry, A (reprint author), York Univ, Dept Psychol, 4700 Keele St, N York, ON M3J 1P3, Canada.
EM ataheri@yorku.ca; perry@yorku.ca
CR American Psychiatric Association, 1980, DIAGN STAT MAN, V3rd
American Psychiatric Association, 1994, DIAGN STAT MAN
American Psychiatric Association, 2010, AUT DIS
American Psychiatric Association, 2000, DIAGN STAT MAN, V4th
American Psychiatric Association, 1987, DIAGN STAT MAN
Frazier TW, 2008, J AUTISM DEV DISORD, V38, P474, DOI 10.1007/s10803-007-0415-z
Frazier TW, 2012, J AM ACAD CHILD PSY, V51, P28, DOI 10.1016/j.jaac.2011.09.021
Gibbs V, 2012, J AUTISM DEV DISORD, V42, P1750, DOI 10.1007/s10803-012-1560-6
Gotham K, 2007, J AUTISM DEV DISORD, V37, P613, DOI 10.1007/s10803-006-0280-1
Gotham K, 2008, J AM ACAD CHILD PSY, V47, P642, DOI 10.1097/CHI.0b013e31816bffb7
Happe F, 2011, J AM ACAD CHILD PSY, V50, P540, DOI 10.1016/j.jaac.2011.03.015
Mandy WPL, 2012, J AM ACAD CHILD PSY, V51, P41, DOI 10.1016/j.jaac.2011.10.013
Matson J. L., DEV NEURORE IN PRESS
Matson JL, 2012, J DEV PHYS DISABIL, V24, P403, DOI 10.1007/s10882-012-9278-0
Mattila ML, 2011, J AM ACAD CHILD PSY, V50, P583, DOI 10.1016/j.jaac.2011.04.001
McPartland JC, 2012, J AM ACAD CHILD PSY, V51, P368, DOI 10.1016/j.jaac.2012.01.007
Mullen E, 1995, MULLEN SCALES EARLY
Roid G. H., 2003, STANFORD BINET INTEL
Schopler E., 1988, CHILDHOOD AUTISM RAT
Shuster J., 2012, REV FACTOR ANA UNPUB
Sparrow SS, 2005, VINELAND ADAPTIVE BE
Swedo SE, 2012, J AM ACAD CHILD PSY, V51, P347, DOI 10.1016/j.jaac.2012.02.013
Tanguay PE, 2011, AM J PSYCHIAT, V168, P1142, DOI 10.1176/appi.ajp.2011.11071024
Thorndike RL, 1986, STANFORD BINET INTEL
Wechsler D., 2002, WECHSLER PRESCHOOL P, V3rd
Wechsler D., 1999, WECHSLER INTELLIGENC
Wing L, 2011, RES DEV DISABIL, V32, P768, DOI 10.1016/j.ridd.2010.11.003
Worley JA, 2012, RES AUTISM SPECT DIS, V6, P965, DOI 10.1016/j.rasd.2011.12.012
NR 28
TC 20
Z9 21
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD SEP
PY 2012
VL 42
IS 9
BP 1810
EP 1817
DI 10.1007/s10803-012-1599-4
PG 8
WC Psychology, Developmental
SC Psychology
GA 992XT
UT WOS:000307815100004
PM 22806000
ER
PT J
AU Smith, LE
Greenberg, JS
Seltzer, MM
AF Smith, Leann E.
Greenberg, Jan S.
Seltzer, Marsha Mailick
TI Social Support and Well-being at Mid-Life Among Mothers of Adolescents
and Adults with Autism Spectrum Disorders
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Social support; Mothers; Well-being; Adolescence; Adulthood
ID PERVASIVE DEVELOPMENTAL DISORDERS; OLDER-ADULTS; YOUNG-ADULTS;
INTELLECTUAL DISABILITY; POSITIVE PERCEPTIONS; PRESCHOOL-CHILDREN;
BEHAVIOR PROBLEMS; MARITAL-STATUS; MENTAL-HEALTH; STRESS
AB The present study investigated the impact of social support on the psychological well-being of mothers of adolescents and adults with ASD (n = 269). Quantity of support (number of social network members) as well as valence of support (positive support and negative support) were assessed using a modified version of the "convoy model" developed by Antonucci and Akiyama (1987). Having a larger social network was associated with improvements in maternal well-being over an 18-month period. Higher levels of negative support as well as increases in negative support over the study period were associated with increases in depressive symptoms and negative affect and decreases in positive affect. Social support predicted changes in well-being above and beyond the impact of child behavior problems. Implications for clinical practice are discussed.
C1 [Smith, Leann E.; Greenberg, Jan S.; Seltzer, Marsha Mailick] Univ Wisconsin, Waisman Ctr, Madison, WI 53705 USA.
RP Smith, LE (reprint author), Univ Wisconsin, Waisman Ctr, 1500 Highland Ave, Madison, WI 53705 USA.
EM lsmith@waisman.wisc.edu
CR Abbeduto L, 2004, AM J MENT RETARD, V109, P237, DOI 10.1352/0895-8017(2004)109<237:PWACIM>2.0.CO;2
Akiyama H., 2003, J GERONTOL B-PSYCHOL, V58, P70, DOI 10.1093/geronb/58.2.P70
ANTONUCCI TC, 1987, J GERONTOL, V42, P519
August KJ, 2010, SOC SCI MED, V71, P1831, DOI 10.1016/j.socscimed.2010.08.022
Barker E. T., 2010, DEV PSYCHOL, V47, P551, DOI [10.1037/a0021268, DOI 10.1037/A0021268]
Benson PR, 2009, J AUTISM DEV DISORD, V39, P350, DOI 10.1007/s10803-008-0632-0
Bishop SL, 2007, AM J MENT RETARD, V112, P450, DOI 10.1352/0895-8017(2007)112[450:POPNII]2.0.CO;2
Blacher J, 2005, CURR OPIN PSYCHIATR, V18, P507, DOI 10.1097/01.yco.0000179488.92885.e8
Bromley J, 2004, AUTISM, V8, P409, DOI 10.1177/1362361304047224
Bruininks R., 1996, SCALES INDEPENDENT B
Carter AS, 2009, J CLIN PSYCHOL, V65, P1270, DOI 10.1002/jclp.20634
COHEN S, 1985, PSYCHOL BULL, V98, P310, DOI 10.1037//0033-2909.98.2.310
Dush CMK, 2005, J SOC PERS RELAT, V22, P607, DOI 10.1177/0265407505056438
Eisenhower AS, 2005, J INTELL DISABIL RES, V49, P657, DOI 10.1111/j.1365-2788.2005.00699.x
Ekas N, 2010, AJIDD-AM J INTELLECT, V115, P234, DOI 10.1352/1944-7558-115.3.234
Ekas NV, 2010, J AUTISM DEV DISORD, V40, P1274, DOI 10.1007/s10803-010-0986-y
FINCH JF, 1989, AM J COMMUN PSYCHOL, V17, P585, DOI 10.1007/BF00922637
Green SA, 2014, J AUTISM DEV DISORD, V44, P256, DOI 10.1007/s10803-011-1275-0
Gurney JG, 2003, ARCH PEDIAT ADOL MED, V157, P622, DOI 10.1001/archpedi.157.7.622
Ha JH, 2010, GERONTOLOGIST, V50, P471, DOI 10.1093/geront/gnp163
Hastings RP, 2002, J APPL RES INTELLECT, V15, P269, DOI 10.1046/j.1468-3148.2002.00104.x
Hastings RP, 2005, J AUTISM DEV DISORD, V35, P635, DOI 10.1007/s10803-005-0007-8
Herring S, 2006, J INTELL DISABIL RES, V50, P874, DOI 10.1111/j.1365-2788.2006.00904.x
Ingersoll B, 2011, RES AUTISM SPECT DIS, V5, P337, DOI 10.1016/j.rasd.2010.04.017
Ingersoll-Dayton B., 1997, J GERONTOLOGY SOCIAL, V52B, P190, DOI DOI 10.1093/GER0NB/52B.4.S190
LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
Lounds J, 2007, AM J MENT RETARD, V112, P401, DOI 10.1352/0895-8017(2007)112[401:TACIAA]2.0.CO;2
McNair D.M., 1971, PROFILE MOOD STATES
Merz EM, 2010, AGEING SOC, V30, P843, DOI 10.1017/S0144686X10000061
PEARLIN LI, 1989, J HEALTH SOC BEHAV, V30, P241, DOI 10.2307/2136956
Pottie CG, 2009, J PEDIATR PSYCHOL, V34, P419, DOI 10.1093/jpepsy/jsn094
RADLOFF L S, 1977, Applied Psychological Measurement, V1, P385, DOI 10.1177/014662167700100306
ROOK KS, 1984, J PERS SOC PSYCHOL, V46, P1097, DOI 10.1037/0022-3514.46.5.1097
Rook K. S., 2001, APPL DEV SCI, V5, P86, DOI [10.1207/S1532480XADS0502_4, DOI 10.1207/S1532480XADS0502_4, 2]
Seltzer MM, 2010, J AUTISM DEV DISORD, V40, P457, DOI 10.1007/s10803-009-0887-0
Shattuck PT, 2011, ARCH PEDIAT ADOL MED, V165, P141, DOI 10.1001/archpediatrics.2010.279
Smith LE, 2012, J AUTISM DEV DISORD, V42, P1836, DOI 10.1007/s10803-011-1422-7
Smith LE, 2010, J AUTISM DEV DISORD, V40, P167, DOI 10.1007/s10803-009-0844-y
Stack S, 1998, J MARRIAGE FAM, V60, P527, DOI 10.2307/353867
Taylor JL, 2011, J AUTISM DEV DISORD, V41, P566, DOI 10.1007/s10803-010-1070-3
Umberson D, 2010, J HEALTH SOC BEHAV, V51, pS54, DOI 10.1177/0022146510383501
Weiss MJ, 2002, AUTISM, V6, P115, DOI 10.1177/1362361302006001009
Windsor TD, 2010, PSYCHOL AGING, V25, P641, DOI 10.1037/a0019431
NR 43
TC 8
Z9 8
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD SEP
PY 2012
VL 42
IS 9
BP 1818
EP 1826
DI 10.1007/s10803-011-1420-9
PG 9
WC Psychology, Developmental
SC Psychology
GA 992XT
UT WOS:000307815100005
PM 22160348
ER
PT J
AU Welterlin, A
Turner-Brown, LM
Harris, S
Mesibov, G
Delmolino, L
AF Welterlin, Aurelie
Turner-Brown, Lauren M.
Harris, Sandra
Mesibov, Gary
Delmolino, Lara
TI The Home TEACCHing Program for Toddlers with Autism
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism; Early intervention; TEACCH; Home-based intervention
ID EARLY INTERVENTION; YOUNG-CHILDREN; COMMUNICATION; PARENTS; TRIAL
AB The study evaluated the efficacy a parent training intervention for children with autism based on the TEACCH model. Twenty families were randomly assigned to the treatment or waitlist group. All families were compared at pre- and post-treatment on formal dependent measures. Direct measures of behavior were compared across six matched pairs using a multiple baseline probe design. The results of the multiple baseline design showed robust support for improvement in child and parent behavior. Due to the sample size and short time frame, results of a repeated measures analysis of variance did not reach significance.
C1 [Welterlin, Aurelie; Turner-Brown, Lauren M.; Mesibov, Gary] Univ N Carolina, Chapel Hill, NC 27515 USA.
[Welterlin, Aurelie; Turner-Brown, Lauren M.; Mesibov, Gary] Rutgers State Univ, Grad Sch Appl & Profess Psychol, Piscataway, NJ 08854 USA.
RP Welterlin, A (reprint author), Univ N Carolina, Chapel Hill, NC 27515 USA.
EM Dr.Welterlin@gmail.com
CR Abidin RR, 1995, PARENTING STRESS IND
Aldred C, 2012, J AUTISM DEV DISORD, V42, P447, DOI 10.1007/s10803-011-1248-3
(APA) APA, 2000, DIAGN STAT MAN MENT
Bruininks R., 1996, SCALES INDEPENDENT B
Carter AS, 2011, J CHILD PSYCHOL PSYC, V52, P741, DOI 10.1111/j.1469-7610.2011.02395.x
Dawson G, 2010, PEDIATRICS, V125, pE17, DOI 10.1542/peds.2009-0958
Diggle T., 2003, COCHRANE DB SYST REV, DOI [10.1002/14651858.CD003496, DOI 10.1002/14651858.CD003496]
Estes A, 2009, AUTISM, V13, P375, DOI 10.1177/1362361309105658
Green J, 2010, LANCET, V375, P2152, DOI 10.1016/S0140-6736(10)60587-9
Gresham FM, 1999, SCHOOL PSYCHOL REV, V28, P559
Kasari C, 2010, J AUTISM DEV DISORD, V40, P1045, DOI 10.1007/s10803-010-0955-5
Kasari C, 2002, J AUTISM DEV DISORD, V32, P447, DOI 10.1023/A:1020546006971
MARCUS LM, 1978, J AM ACAD CHILD PSY, V17, P625, DOI 10.1016/S0002-7138(09)61016-5
McGee GG, 1999, J ASSOC PERS SEVERE, V24, P133, DOI 10.2511/rpsd.24.3.133
MESIBOV GB, 1994, CURR I AUT, P195
Mesibov GB, 2011, AUTISM, V15, P114, DOI 10.1177/1362361309348070
Mesibov GB, 2005, TEACCH APPROACH AUTI
Mullen E, 1995, MULLEN SCALES EARLY
Odom SL, 2010, J AUTISM DEV DISORD, V40, P425, DOI 10.1007/s10803-009-0825-1
Ozonoff S, 1998, J AUTISM DEV DISORD, V28, P25, DOI 10.1023/A:1026006818310
Panerai S, 2002, J INTELL DISABIL RES, V46, P318, DOI 10.1046/j.1365-2788.2002.00388.x
Quill KA, 1997, J AUTISM DEV DISORD, V27, P697, DOI 10.1023/A:1025806900162
Rogers SJ, 2008, J CLIN CHILD ADOLESC, V37, P8, DOI 10.1080/15374410701817808
Schertz HH, 2007, J AUTISM DEV DISORD, V37, P1562, DOI 10.1007/s10803-006-0290-z
Schopler E, 1990, PSYCHOEDUCATIONAL PR, V1
Schopler E., 1994, CHILD ADOL PSYCH CL, V3, P91
SHORT AB, 1984, J CHILD PSYCHOL PSYC, V25, P443, DOI 10.1111/j.1469-7610.1984.tb00163.x
Smith T, 2000, AM J MENT RETARD, V105, P269, DOI 10.1352/0895-8017(2000)105<0269:RTOIEI>2.0.CO;2
Yoder P, 2006, J SPEECH LANG HEAR R, V49, P698, DOI 10.1044/1092-4388(2006/051)
NR 29
TC 10
Z9 10
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD SEP
PY 2012
VL 42
IS 9
BP 1827
EP 1835
DI 10.1007/s10803-011-1419-2
PG 9
WC Psychology, Developmental
SC Psychology
GA 992XT
UT WOS:000307815100006
PM 22160347
ER
PT J
AU Smith, LE
Seltzer, MM
Greenberg, JS
AF Smith, Leann E.
Seltzer, Marsha Mailick
Greenberg, Jan S.
TI Daily Health Symptoms of Mothers of Adolescents and Adults with Fragile
X Syndrome and Mothers of Adolescents and Adults with Autism Spectrum
Disorder
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Fragile X premutation; Autism spectrum disorders; Health symptoms
ID PERVASIVE DEVELOPMENTAL DISORDERS; FMR1 PREMUTATION; INTELLECTUAL
DISABILITY; CLINICAL INVOLVEMENT; SYNDROME SPECIFICITY; BEHAVIOR
PROBLEMS; DOWN-SYNDROME; CARRIERS; PERSPECTIVE; PHENOTYPES
AB Health symptoms of mothers of adolescents and adults with fragile X syndrome (FXS; n = 112) were compared to a nationally-representative sample of mothers of similarly-aged children without disabilities (n = 230) as well as to a sample of mothers of adolescents and adults with autism spectrum disorders (ASD; n = 96). Health symptoms experienced in the previous 24 h were recorded during 8 consecutive days of a daily diary study. Both mothers of a son or daughter with FXS and mothers of a son or daughter with ASD had a higher proportion of days with headaches, backaches, muscle soreness, fatigue, and hot flashes than mothers of children without disabilities. Mothers of children with disabilities appear to be at particular risk for health problems, highlighting a need for comprehensive services for families across the lifespan.
C1 [Smith, Leann E.; Seltzer, Marsha Mailick; Greenberg, Jan S.] Univ Wisconsin, Waisman Ctr, Madison, WI 53705 USA.
RP Smith, LE (reprint author), Univ Wisconsin, Waisman Ctr, 1500 Highland Ave, Madison, WI 53705 USA.
EM lsmith@waisman.wisc.edu
CR Abbeduto L, 2004, AM J MENT RETARD, V109, P237, DOI 10.1352/0895-8017(2004)109<237:PWACIM>2.0.CO;2
Bailey DB, 2008, AM J MED GENET A, V146A, P2060, DOI 10.1002/ajmg.a.32439
Barker ET, 2011, DEV PSYCHOL, V47, P551, DOI 10.1037/a0021268
Berry-Kravis E, 2005, ANN NEUROL, V57, P144, DOI 10.1002/ana.20360
Blacher J, 2006, J INTELL DISABIL RES, V50, P184, DOI 10.1111/j.1365-2788.2005.00768.x
Bourgeois J. A., 2010, J CLIN PSYCHIAT, DOI [10.4088/PCP.09m05407blu, DOI 10.4088/PCP.09M05407BLU]
Bourgeois JA, 2009, J CLIN PSYCHIAT, V70, P852, DOI 10.4088/JCP.08m04476
Brim OG, 2004, MAC FDN MEN, P1
Bruininks R., 1996, SCALES INDEPENDENT B
Chonchaiya W, 2010, CLIN GENET, V78, P38, DOI 10.1111/j.1399-0004.2010.01448.x
Chonchaiya W, 2009, J DEV BEHAV PEDIATR, V30, P544, DOI 10.1097/DBP.0b013e3181c35f25
Coffey SM, 2008, AM J MED GENET A, V146A, P1009, DOI 10.1002/ajmg.a.32060
Cohen S, 2006, CURR DIR PSYCHOL SCI, V15, P122, DOI 10.1111/j.0963-7214.2006.00420.x
Cornish KM, 2011, NEUROLOGY, V77, P618, DOI 10.1212/WNL.0b013e3182299e59
Derogatis L., 1997, SYMPTOM CHECKLIST 90
Eisenhower AS, 2005, J INTELL DISABIL RES, V49, P657, DOI 10.1111/j.1365-2788.2005.00699.x
First M. B., 2002, USERS GUIDE STRUCTUR
Franke P, 1998, PSYCHIAT RES, V80, P113, DOI 10.1016/S0165-1781(98)00055-9
Goodrich-Hunsaker N. J., 2011, FRONT HUM NEUROSCI, V5, P1
Gruenewald TL, 2008, DEV PSYCHOL, V44, P330, DOI 10.1037/0012-1649.44.2.330
Hagerman PJ, 2004, AM J HUM GENET, V74, P805, DOI 10.1086/386296
Hartley S. L., 2011, INT J BEHAV DEV
Herring S, 2006, J INTELL DISABIL RES, V50, P874, DOI 10.1111/j.1365-2788.2006.00904.x
Hunter JE, 2008, BEHAV GENET, V38, P493, DOI 10.1007/s10519-008-9214-3
Hunter JE, 2009, GENET MED, V11, P79, DOI 10.1097/GIM.0b013e31818de6ee
Hunter JE, 2008, AM J HUM GENET, V83, P692, DOI 10.1016/j.ajhg.2008.10.021
Hunter JE, 2010, CLIN GENET, V77, P374, DOI 10.1111/j.1399-0004.2009.01317.x
Lachiewicz A, 2010, J INTELL DISABIL RES, V54, P597, DOI 10.1111/j.1365-2788.2010.01290.x
LARSEN RJ, 1991, J PERS, V59, P387, DOI 10.1111/j.1467-6494.1991.tb00254.x
LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
McEwen BS, 1998, NEW ENGL J MED, V338, P171
Piven J, 1997, AM J MED GENET, V74, P398, DOI 10.1002/(SICI)1096-8628(19970725)74:4<398::AID-AJMG11>3.0.CO;2-D
Roberts JE, 2009, AM J MED GENET B, V150B, P130, DOI 10.1002/ajmg.b.30786
Rodriguez-Revenga L, 2008, PSYCHIAT GENET, V18, P153, DOI 10.1097/YPG.0b013e3282f97e0b
Rodriguez-Revenga L, 2009, EUR J HUM GENET, V17, P1359, DOI 10.1038/ejhg.2009.51
Rutter M., 2003, ADI R AUTISM DIAGNOS
Segerstrom SC, 2004, PSYCHOL BULL, V130, P601, DOI 10.1037/0033-2909.130.4.601
Seltzer M. M., HLTH PSYCHO IN PRESS
Seltzer M. M., 2011, AUTISM SPECTRUM DISO, P241, DOI DOI 10.1093/MED/9780195371826.003.0016
Seltzer MM, 2009, J HEALTH SOC BEHAV, V50, P1
Seltzer MM, 2010, J AUTISM DEV DISORD, V40, P457, DOI 10.1007/s10803-009-0887-0
Seltzer MM, 2004, J AUTISM DEV DISORD, V34, P41, DOI 10.1023/B:JADD.0000018073.92982.64
Smith LE, 2010, J AUTISM DEV DISORD, V40, P167, DOI 10.1007/s10803-009-0844-y
Smith LE, AM J INTELL IN PRESS
Song F J, 2003, Health Technol Assess, V7, P1
Sullivan AK, 2005, HUM REPROD, V20, P402, DOI 10.1093/humrep/deh635
WATSON D, 1988, J PERS SOC PSYCHOL, V54, P1063, DOI 10.1037/0022-3514.54.6.1063
Wittenberger MD, 2007, FERTIL STERIL, V87, P456, DOI 10.1016/j.fertnstert.2006.09.004
Xu JP, 2010, HEALTH PSYCHOL, V29, P9, DOI 10.1037/a0016767
NR 49
TC 10
Z9 11
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD SEP
PY 2012
VL 42
IS 9
BP 1836
EP 1846
DI 10.1007/s10803-011-1422-7
PG 11
WC Psychology, Developmental
SC Psychology
GA 992XT
UT WOS:000307815100007
PM 22167342
ER
PT J
AU Strauss, MS
Newell, LC
Best, CA
Hannigen, SF
Gastgeb, HZ
Giovannelli, JL
AF Strauss, Mark S.
Newell, Lisa C.
Best, Catherine A.
Hannigen, Sarah F.
Gastgeb, Holly Zajac
Giovannelli, Joyce L.
TI The Development of Facial Gender Categorization in Individuals with and
without Autism: The Impact of Typicality
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Gender categorization; Typicality; Face perception; Autism
ID FEMALE FACES; RECOGNITION; SPECTRUM; CHILDREN; PERCEPTION; DISORDERS;
EMOTION; INFANCY; SPACE; SEX
AB While much research has examined the development of facial recognition abilities, less is known about the ability of individuals with and without autism to categorize facial gender. The current study tested gender categorization abilities in high-functioning children (5-7 and 8-12 years), adolescents (13-17 years), and adults (18-53 years) with autism and matched controls. Naturalistic videos depicted faces that were either typical or less typical of each gender. Both groups improved in their performance across development. However, control children reached expertise that was similar to control adults by 8-12 years; whereas, adults with autism never reached this level of expertise, particularly with less typical gender faces. Results suggest that individuals with autism employ different face processing mechanisms than typically developing individuals.
C1 [Strauss, Mark S.; Best, Catherine A.; Hannigen, Sarah F.; Gastgeb, Holly Zajac] Univ Pittsburgh, Dept Psychol, Pittsburgh, PA 15260 USA.
[Newell, Lisa C.] Indiana Univ Penn, Dept Psychol, Indiana, PA USA.
[Best, Catherine A.] Ohio State Univ, Dept Psychol, Columbus, OH 43210 USA.
[Gastgeb, Holly Zajac] Univ Pittsburgh, Dept Psychiat, Sch Med, Pittsburgh, PA 15260 USA.
[Giovannelli, Joyce L.] Childrens Adv, Ravenna, OH USA.
RP Strauss, MS (reprint author), Univ Pittsburgh, Dept Psychol, 210 S Bouquet St, Pittsburgh, PA 15260 USA.
EM strauss@pitt.edu
CR Behrmann M, 2006, NEUROPSYCHOLOGIA, V44, P110, DOI 10.1016/j.neuropsychologia.2005.04.002
Best CA, 2010, AUTISM RES, V3, P88, DOI 10.1002/aur.125
Bestelmeyer PEG, 2008, COGNITION, V107, P353, DOI 10.1016/j.cognition.2007.07.018
BROWN E, 1993, PERCEPTION, V22, P829, DOI 10.1068/p220829
CHRONICLE EP, 1995, PERCEPTION, V24, P969, DOI 10.1068/p240969
Curby K., 2010, PERCEPTUAL EXPERTISE
Deruelle C, 2004, J AUTISM DEV DISORD, V34, P199, DOI 10.1023/B:JADD.0000022610.09668.4c
Dunn L. M., 1981, PEABODY PICTURE VOCA
Faja S, 2008, DEV NEUROPSYCHOL, V33, P1, DOI 10.1080/87565640701729573
FRITH U, 1994, COGNITION, V50, P115, DOI 10.1016/0010-0277(94)90024-8
Gastgeb H., 2009, AUTISM RES, V2, P1
Gastgeb HZ, 2006, CHILD DEV, V77, P1717, DOI 10.1111/j.1467-8624.2006.00969.x
Gastgeb HZ, 2011, J AUTISM DEV DISORD, V41, P1609, DOI 10.1007/s10803-011-1190-4
Gauthier I., 2010, PERCEPTUAL EXPERTISE
HOBSON RP, 1986, J CHILD PSYCHOL PSYC, V27, P321, DOI 10.1111/j.1469-7610.1986.tb01836.x
HOBSON RP, 1988, BRIT J PSYCHOL, V79, P441
Jaquet E, 2008, J EXP PSYCHOL HUMAN, V34, P101, DOI 10.1037/0096-1523.34.1.101
Klinger L., 2006, NEW DEV AUTISM FUTUR, P75
Klinger LG, 2001, DEV PSYCHOPATHOL, V13, P111, DOI 10.1017/S0954579401001080
LEINBACH MD, 1993, INFANT BEHAV DEV, V16, P317, DOI 10.1016/0163-6383(93)80038-A
LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
Mondlach C. J., 2010, PERCEPTUAL EXPERTISE
Mottron L, 2006, J AUTISM DEV DISORD, V36, P27, DOI 10.1007/s10803-005-0040-7
Murphy G. L, 2004, BIG BOOK CONCEPTS
Newell L. C., 2010, INFORM PROCESSING IN
Nijiokiktjien C., 2001, EUROPEAN CHILD ADOLE, V10, P79
O'Toole AJ, 1998, MEM COGNITION, V26, P146, DOI 10.3758/BF03211378
Plaisted K. C., 2000, UNDERSTANDING OTHER
Quinn PC, 2002, PERCEPTION, V31, P1109, DOI 10.1068/p3331
Rhodes G., 2011, OXFORD HDB FACE PERC
Rump KM, 2009, CHILD DEV, V80, P1434, DOI 10.1111/j.1467-8624.2009.01343.x
Slater A, 2010, CHILD DEV PERSPECT, V4, P205, DOI 10.1111/j.1750-8606.2010.00147.x
Valentine T, 2001, SCI PSYCH S, P83
Wechsler D, 1999, WECHSLER ABBREVIATED
WEEKS SJ, 1987, J CHILD PSYCHOL PSYC, V28, P137, DOI 10.1111/j.1469-7610.1987.tb00658.x
Wolf JM, 2008, AUTISM RES, V1, P329, DOI 10.1002/aur.56
NR 37
TC 1
Z9 1
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD SEP
PY 2012
VL 42
IS 9
BP 1847
EP 1855
DI 10.1007/s10803-011-1428-1
PG 9
WC Psychology, Developmental
SC Psychology
GA 992XT
UT WOS:000307815100008
PM 22200937
ER
PT J
AU Cheely, CA
Carpenter, LA
Letourneau, EJ
Nicholas, JS
Charles, J
King, LB
AF Cheely, Catherine A.
Carpenter, Laura A.
Letourneau, Elizabeth J.
Nicholas, Joyce S.
Charles, Jane
King, Lydia B.
TI The Prevalence of Youth with Autism Spectrum Disorders in the Criminal
Justice System
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism; Autism spectrum disorders; Criminality; Juvenile justice
ID JUVENILE; DISABILITIES; OFFENDERS
AB Past surveys have reported high rates of youth with disabilities in the juvenile justice system, however, little research has examined the frequency with which youth with Autism spectrum disorders (ASD) are in contact with law enforcement. Using records linkage with the Department of Juvenile Justice and the South Carolina Law Enforcement Division and the South Carolina Autism and Developmental Disabilities Monitoring Program (SC ADDM), this study compares the frequency, type, and outcome of criminal charges for youth with ASD and non-ASD youth. Youth with ASD had higher rates of crimes against persons and lower rates of crimes against property. Youth with ASD were more likely to be diverted into pre-trial interventions and less likely to be prosecuted than comparison youth. When compared to the overall SC ADDM sample, charged youth were less likely to have comorbid intellectual disability.
C1 [Cheely, Catherine A.; Letourneau, Elizabeth J.] Med Univ S Carolina, Family Serv Res Ctr, Charleston, SC 29425 USA.
RP Cheely, CA (reprint author), Med Univ S Carolina, Family Serv Res Ctr, 135 Rutledge Ave,MSC 567, Charleston, SC 29425 USA.
EM cheely@musc.edu
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
Braun Kim Van Naarden, 2007, Morbidity and Mortality Weekly Report, V56, P29
Brookman-Frazee L, 2009, J MENT HEALTH RES IN, V2, P201, DOI 10.1080/19315860902741542
Mayes TA, 2003, J POSIT BEHAV INTERV, V5, P92, DOI 10.1177/10983007030050020401
O'Hearn K, 2008, DEV PSYCHOPATHOL, V20, P1103, DOI 10.1017/S0954579408000527
Quinn MM, 2005, EXCEPT CHILDREN, V71, P339
Siponmaa L, 2001, J AM ACAD PSYCHIATRY, V29, P420
Teplin LA, 2002, ARCH GEN PSYCHIAT, V59, P1133, DOI 10.1001/archpsyc.59.12.1133
van Roekel E, 2010, J AUTISM DEV DISORD, V40, P63, DOI 10.1007/s10803-009-0832-2
Vermeiren R, 2006, CHILD ADOL PSYCH CL, V15, P333, DOI 10.1016/j.chc.2005.11.008
Woodbury-Smith MR, 2006, J FORENSIC PSYCHI PS, V17, P108, DOI 10.1080/14789940600589464
Woodbury-Smith MR, 2005, J FORENSIC PSYCHI PS, V16, P747, DOI 10.1080/14789940500302554
NR 12
TC 4
Z9 4
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD SEP
PY 2012
VL 42
IS 9
BP 1856
EP 1862
DI 10.1007/s10803-011-1427-2
PG 7
WC Psychology, Developmental
SC Psychology
GA 992XT
UT WOS:000307815100009
PM 22187108
ER
PT J
AU Siegel, M
Doyle, K
Chemelski, B
Payne, D
Ellsworth, B
Harmon, J
Robbins, D
Milligan, B
Lubetsky, M
AF Siegel, Matthew
Doyle, Kathleen
Chemelski, Bruce
Payne, David
Ellsworth, Beth
Harmon, Jamie
Robbins, Douglas
Milligan, Briana
Lubetsky, Martin
TI Specialized Inpatient Psychiatry Units for Children with Autism and
Developmental Disorders: A United States Survey
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism; Inpatient; Developmental; Admission
ID INTELLECTUAL DISABILITY; CARE
AB A cross sectional survey was performed to obtain the characteristics of specialized inpatient psychiatry units exclusively serving children with autism and other developmental disorders in the United States. Identified units were surveyed on basic demographic characteristics, clinical challenges and therapeutic modalities. Average length of stay was 42.3 days, children with autism spectrum disorders constituted the majority of the inpatient population (62.5-87.5%), and obtaining adequate post-discharge services was identified as the greatest challenge. Health policy implications and future research directions are suggested.
C1 [Siegel, Matthew; Chemelski, Bruce; Payne, David; Ellsworth, Beth; Harmon, Jamie; Milligan, Briana] Spring Harbor Hosp & Maine Med Ctr, Dev Disorders Program, Westbrook, ME 04092 USA.
[Siegel, Matthew] Tufts Univ, Sch Med, Dept Psychiat, Boston, MA 02111 USA.
[Doyle, Kathleen] Mt Holyoke Coll, S Hadley, MA 01075 USA.
[Robbins, Douglas] Maine Med Ctr, Div Child Psychiat, Portland, ME 04102 USA.
[Lubetsky, Martin] Western Psychiat Inst & Clin, Div Child Psychiat, Pittsburgh, PA USA.
RP Siegel, M (reprint author), Spring Harbor Hosp & Maine Med Ctr, Dev Disorders Program, 123 Andover Rd, Westbrook, ME 04092 USA.
EM siegem@springharbor.org
CR Barrett R. P., 1992, INPATIENT BEHAV THER, P113
Croen L. A., 2006, PEDIATRICS, V118, P1203
Dekker MC, 2003, J AM ACAD CHILD PSY, V42, P915, DOI 10.1097/01.CHI.0000046892.27264.1A
Holt G, 2001, TXB COMMUNITY PSYCHI, P397
Kwok H. W. M., 2001, BRIT J LEARNING DISA, V29, P22, DOI 10.1046/j.1468-3156.2001.00095.x
Lennox N, 1995, AUST NZ J PSYCHIAT, V29, P632, DOI 10.3109/00048679509064978
Liptak GS, 2006, J AUTISM DEV DISORD, V36, P871, DOI 10.1007/s10803-006-0119-9
National Association of Psychiatric Health Systems, 2009, ANN SURV
Simonoff E, 2008, J AM ACAD CHILD PSY, V47, P921, DOI 10.1097/CHI.0b013e318179964f
Smith P, 2006, J INTELL DISABIL RES, V50, P608, DOI 10.1111/j.1365-2788.2006.00866.x
NR 10
TC 4
Z9 4
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD SEP
PY 2012
VL 42
IS 9
BP 1863
EP 1869
DI 10.1007/s10803-011-1426-3
PG 7
WC Psychology, Developmental
SC Psychology
GA 992XT
UT WOS:000307815100010
PM 22189962
ER
PT J
AU Paton, B
Hohwy, J
Enticott, PG
AF Paton, Bryan
Hohwy, Jakob
Enticott, Peter G.
TI The Rubber Hand Illusion Reveals Proprioceptive and Sensorimotor
Differences in Autism Spectrum Disorders
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE High-functioning autism spectrum disorder; Rubber hand illusion;
Multimodal sensory integration; Local processing bias
ID HIGH-FUNCTIONING AUTISM; WEAK CENTRAL COHERENCE; MIRROR NEURONS; SENSORY
INTEGRATION; ASPERGERS-DISORDER; BODY EXPERIENCES; CHILDREN; MOVEMENT;
INDIVIDUALS; PERCEPTION
AB Autism spectrum disorder (ASD) is characterised by differences in unimodal and multimodal sensory and proprioceptive processing, with complex biases towards local over global processing. Many of these elements are implicated in versions of the rubber hand illusion (RHI), which were therefore studied in high-functioning individuals with ASD and a typically developing control group. Both groups experienced the illusion. A number of differences were found, related to proprioception and sensorimotor processes. The ASD group showed reduced sensitivity to visuotactile-proprioceptive discrepancy but more accurate proprioception. This group also differed on acceleration in subsequent reach trials. Results are discussed in terms of weak top-down integration and precision-accuracy trade-offs. The RHI appears to be a useful tool for investigating multisensory processing in ASD.
C1 [Paton, Bryan; Hohwy, Jakob] Monash Univ, Dept Philosophy, Melbourne, Vic 3004, Australia.
[Enticott, Peter G.] Monash Univ, Sch Psychol & Psychiat, Monash Alfred Psychiat Res Ctr, Melbourne, Vic 3004, Australia.
RP Hohwy, J (reprint author), Monash Univ, Dept Philosophy, Melbourne, Vic 3004, Australia.
EM Jakob.Hohwy@monash.edu
CR Alais D, 2004, CURR BIOL, V14, P257, DOI 10.1016/j.cub.2004.01.029
Armel KC, 2003, P ROY SOC B-BIOL SCI, V270, P1499, DOI 10.1098/rspb.2003.2364
Baron-Cohen S, 2004, J AUTISM DEV DISORD, V34, P163, DOI 10.1023/B:JADD.0000022607.19833.00
Bays PM, 2007, J PHYSIOL-LONDON, V578, P387, DOI 10.1113/jphysiol.2006.120121
Bebko JM, 2006, J CHILD PSYCHOL PSYC, V47, P88, DOI 10.1111/j.1469-7610.2005.01443.x
Ben-Sasson A, 2009, J AUTISM DEV DISORD, V39, P1, DOI 10.1007/s10803-008-0593-3
Bolte S, 2007, J AUTISM DEV DISORD, V37, P1493, DOI 10.1007/s10803-006-0231-x
Bonnel A, 2003, J COGNITIVE NEUROSCI, V15, P226, DOI 10.1162/089892903321208169
Botvinick M, 1998, NATURE, V391, P756, DOI 10.1038/35784
Cascio C, 2008, J AUTISM DEV DISORD, V38, P127, DOI 10.1007/s10803-007-0370-8
Chong TW, 2004, SCHIZOPHR RES, V69, P149, DOI 10.1016/S0920-9964(03)00222-6
Cook I., 2005, HDB AUTISM PERVASIVE, P382
Dakin S, 2005, NEURON, V48, P497, DOI 10.1016/j.neuron.2005.10.018
Desmurget M, 2000, EXP BRAIN RES, V134, P363, DOI 10.1007/s002210000473
Ehrsson HH, 2004, SCIENCE, V305, P875, DOI 10.1126/science.1097011
Ehrsson HH, 2007, SCIENCE, V317, P1048, DOI 10.1126/science.1142175
Enticott PG, 2012, BIOL PSYCHIAT, V71, P427, DOI 10.1016/j.biopsych.2011.09.001
Enticott PG, 2010, NEUROPSYCHOLOGIA, V48, P2675, DOI 10.1016/j.neuropsychologia.2010.05.014
Ernst MO, 2002, NATURE, V415, P429, DOI 10.1038/415429a
Fiorio M, 2011, BRAIN, V134, P1428, DOI 10.1093/brain/awr026
Foss-Feig JH, 2010, EXP BRAIN RES, V203, P381, DOI 10.1007/s00221-010-2240-4
Frith U., 1989, AUTISM EXPLAINING EN
Fuentes C., 2010, J AUTISM DEV DISORD, V41, P1352
Gallese V, 1998, TRENDS COGN SCI, V2, P493, DOI 10.1016/S1364-6613(98)01262-5
GEPNER B, 1995, NEUROREPORT, V6, P1211, DOI 10.1097/00001756-199505300-00034
Gepner B, 2002, J AUTISM DEV DISORD, V32, P231, DOI 10.1023/A:1015410015859
Giummarra MJ, 2008, NEUROSCI BIOBEHAV R, V32, P143, DOI 10.1016/j.neubiorev.2007.07.001
GROSS Y, 1978, EXP NEUROL, V61, P680, DOI 10.1016/0014-4886(78)90032-8
GROSS Y, 1974, EXP NEUROL, V44, P346, DOI 10.1016/0014-4886(74)90201-5
Guterstam A, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0017208
Haans A, 2008, BODY IMAGE, V5, P389, DOI 10.1016/j.bodyim.2008.04.003
Happe F, 2006, J AUTISM DEV DISORD, V36, P5, DOI 10.1007/s10803-005-0039-0
Happe FGE, 1996, J CHILD PSYCHOL PSYC, V37, P873, DOI 10.1111/j.1469-7610.1996.tb01483.x
Haswell CC, 2009, NAT NEUROSCI, V12, P970, DOI 10.1038/nn.2356
Hohwy J, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009416
Hoy JA, 2004, AUTISM, V8, P267, DOI 10.1177/1362361304045218
Iacoboni M, 2006, NAT REV NEUROSCI, V7, P942, DOI 10.1038/nrn2024
Iarocci G, 2006, J AUTISM DEV DISORD, V36, P77, DOI 10.1007/s10803-005-0044-3
Ionta S, 2011, NEURON, V70, P363, DOI 10.1016/j.neuron.2011.03.009
JEANNEROD M, 1986, NEUROPSYCHOLOGIA, V24, P41, DOI 10.1016/0028-3932(86)90042-4
Kaiser MD, 2012, DEV COGN NEUROS-NETH, V2, P25, DOI 10.1016/j.dcn.2011.05.005
Kammers MPM, 2009, PERCEPTION, V38, P1804, DOI 10.1068/p6389
Kammers MPM, 2011, NEUROPSYCHOLOGIA, V49, P1316, DOI 10.1016/j.neuropsychologia.2011.02.039
Kammers MPM, 2010, EXP BRAIN RES, V202, P203, DOI 10.1007/s00221-009-2124-7
Kammers MPM, 2009, NEUROPSYCHOLOGIA, V47, P204, DOI 10.1016/j.neuropsychologia.2008.07.028
Kammers MPM, 2009, J COGNITIVE NEUROSCI, V21, P1311, DOI 10.1162/jocn.2009.21095
Kording KP, 2004, NATURE, V427, P244, DOI 10.1038/nature02169
Kwakye Leslie D, 2011, Front Integr Neurosci, V4, P129, DOI 10.3389/fnint.2010.00129
Lenggenhager B, 2007, SCIENCE, V317, P1096, DOI 10.1126/science.1143439
Longo MR, 2008, COGNITION, V107, P978, DOI 10.1016/j.cognition.2007.12.004
Makin TR, 2008, BEHAV BRAIN RES, V191, P1, DOI 10.1016/j.bbr.2008.02.041
Mari M, 2003, PHILOS T ROY SOC B, V358, P393, DOI 10.1098/rstb.2002.1205
MASTERTON BA, 1983, J AUTISM DEV DISORD, V13, P141, DOI 10.1007/BF01531815
Moseley GL, 2012, NEUROSCI BIOBEHAV R, V36, P34, DOI 10.1016/j.neubiorev.2011.03.013
Moseley GL, 2008, P NATL ACAD SCI USA, V105, P13169, DOI 10.1073/pnas.0803768105
Mottron L, 2006, J AUTISM DEV DISORD, V36, P27, DOI 10.1007/s10803-005-0040-7
Mussap AJ, 2006, J HEALTH PSYCHOL, V11, P627, DOI 10.1177/1359105306065022
Nayate A, 2005, BRAIN RES BULL, V67, P327, DOI 10.1016/j.brainresbull.2005.07.011
Nazarali N, 2009, J AUTISM DEV DISORD, V39, P1401, DOI 10.1007/s10803-009-0756-x
Oberman LM, 2005, COGNITIVE BRAIN RES, V24, P190, DOI 10.1016/j.cogbrainres.2005.01.014
Peled A, 2003, SCHIZOPHR RES, V64, P157, DOI 10.1016/S0920-9964(03)00057-4
Peled A, 2000, BIOL PSYCHIAT, V48, P1105, DOI 10.1016/S0006-3223(00)00947-1
Petkova VI, 2008, PLOS ONE, V3, DOI 10.1371/journal.pone.0003832
Recanzone GH, 1998, P NATL ACAD SCI USA, V95, P869, DOI 10.1073/pnas.95.3.869
Rinehart NJ, 2006, DEV MED CHILD NEUROL, V48, P272, DOI 10.1017/S0012162206000594
Rinehart NJ, 2001, J AUTISM DEV DISORD, V31, P79, DOI 10.1023/A:1005617831035
Rippon G, 2007, INT J PSYCHOPHYSIOL, V63, P164, DOI 10.1016/j.ijpsycho.2006.03.012
Rogers SJ, 2005, J CHILD PSYCHOL PSYC, V46, P1255, DOI 10.1111/j.1469-7610.2005.01431.x
Rohde M, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0021659
Ropar D, 1999, J CHILD PSYCHOL PSYC, V40, P1283, DOI 10.1017/S0021963099004667
Ropar D, 2001, J CHILD PSYCHOL PSYC, V42, P539, DOI 10.1111/1469-7610.00748
Ropar D, 2002, J CHILD PSYCHOL PSYC, V43, P647, DOI 10.1111/1469-7610.00053
ROSSETTI Y, 1995, J NEUROPHYSIOL, V74, P457
Schwabe L, 2008, FRONT HUM NEUROSCI, V2, DOI 10.3389/neuro.09.017.2008
Simmons DR, 2009, VISION RES, V49, P2705, DOI 10.1016/j.visres.2009.08.005
Smith EG, 2007, J CHILD PSYCHOL PSYC, V48, P813, DOI 10.1111/j.1469-7610.2007.01766.x
Sober SJ, 2003, J NEUROSCI, V23, P6982
Sober SJ, 2005, NAT NEUROSCI, V8, P490, DOI 10.1038/nn1427
Theoret H, 2005, CURR BIOL, V15, pR84, DOI 10.1016/j.cub.2005.01.022
Tsakiris M, 2010, NEUROPSYCHOLOGIA, V48, P703, DOI 10.1016/j.neuropsychologia.2009.09.034
Tsakiris M, 2005, J EXP PSYCHOL HUMAN, V31, P80, DOI 10.1037/0096-1523.31.1.80
Tsakiris M, 2010, EXP BRAIN RES, V204, P343, DOI 10.1007/s00221-009-2039-3
van Beers RJ, 2002, CURR BIOL, V12, P834, DOI 10.1016/S0960-9822(02)00836-9
van Beers RJ, 1999, J NEUROPHYSIOL, V81, P1355
Walter E, 2009, J AUTISM DEV DISORD, V39, P339, DOI 10.1007/s10803-008-0630-2
WANN JP, 1992, EXP BRAIN RES, V91, P162
Williams JHG, 2001, NEUROSCI BIOBEHAV R, V25, P287, DOI 10.1016/S0149-7634(01)00014-8
Zopf R, 2011, NEUROPSYCHOLOGIA, V49, P1287, DOI 10.1016/j.neuropsychologia.2011.02.012
NR 88
TC 10
Z9 10
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD SEP
PY 2012
VL 42
IS 9
BP 1870
EP 1883
DI 10.1007/s10803-011-1430-7
PG 14
WC Psychology, Developmental
SC Psychology
GA 992XT
UT WOS:000307815100011
PM 22189963
ER
PT J
AU Cornew, L
Roberts, TPL
Blaskey, L
Edgar, JC
AF Cornew, Lauren
Roberts, Timothy P. L.
Blaskey, Lisa
Edgar, J. Christopher
TI Resting-State Oscillatory Activity in Autism Spectrum Disorders
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism; Magnetoencephalography; Resting-state; Oscillations; Alpha;
Gamma
ID INTERNEURON DEVELOPMENT; MINICOLUMNAR PATHOLOGY; EEG ABNORMALITIES;
BRAIN DYNAMICS; BASE-LINE; EPILEPSY; RHYTHMS; MEG; NETWORK; ALPHA
AB Neural oscillatory anomalies in autism spectrum disorders (ASD) suggest an excitatory/inhibitory imbalance; however, the nature and clinical relevance of these anomalies are unclear. Whole-cortex magnetoencephalography data were collected while 50 children (27 with ASD, 23 controls) underwent an eyes-closed resting-state exam. A Fast Fourier Transform was applied and oscillatory activity examined from 1 to 120 Hz at 15 regional sources. Associations between oscillatory anomalies and symptom severity were probed. Children with ASD exhibited regionally specific elevations in delta (1-4 Hz), theta (4-8 Hz), alpha (8-12 Hz), and high frequency (20-120 Hz) power, supporting an imbalance of neural excitation/inhibition as a neurobiological feature of ASD. Increased temporal and parietal alpha power was associated with greater symptom severity and thus is of particular interest.
C1 [Cornew, Lauren; Roberts, Timothy P. L.; Blaskey, Lisa; Edgar, J. Christopher] Childrens Hosp Philadelphia, Lurie Family Fdn MEG Imaging Ctr, Dept Radiol, Philadelphia, PA 19104 USA.
[Blaskey, Lisa] Childrens Hosp Philadelphia, Ctr Autism Res, Dept Pediat, Philadelphia, PA 19104 USA.
RP Roberts, TPL (reprint author), Childrens Hosp Philadelphia, Lurie Family Fdn MEG Imaging Ctr, Dept Radiol, 2nd Floor Wood Bldg,Room 2115,Mail Stop W02-1010, Philadelphia, PA 19104 USA.
EM robertstim@email.chop.edu
CR Aftanas LI, 2005, INT J PSYCHOPHYSIOL, V55, P85, DOI 10.1016/j.ijpsycho.2004.06.004
Arick J. R., 2003, KRUG ASPERGERS DISOR
Blume WT, 2006, J CLIN NEUROPHYSIOL, V23, P306, DOI 10.1097/01.wnp.0000229137.94384.fa
Bosboom JLW, 2006, CLIN NEUROPHYSIOL, V117, P2521, DOI 10.1016/j.clinph.2006.06.720
Bourgeron T, 2009, CURR OPIN NEUROBIOL, V19, P231, DOI 10.1016/j.conb.2009.06.003
Canitano R, 2007, EUR CHILD ADOLES PSY, V16, P61, DOI 10.1007/s00787-006-0563-2
CANTOR DS, 1986, J AUTISM DEV DISORD, V16, P169, DOI 10.1007/BF01531728
Cardy JEO, 2005, NEUROREPORT, V16, P329
Casanova MF, 2002, NEUROLOGY, V58, P428
Casanova MF, 2002, J CHILD NEUROL, V17, P692, DOI 10.1177/088307380201700908
Cherkassky VL, 2006, NEUROREPORT, V17, P1687, DOI 10.1097/01.wnr.0000239956.45448.4c
Chez MG, 2006, EPILEPSY BEHAV, V8, P267, DOI 10.1016/j.yebeh.2005.11.001
Coben R, 2008, CLIN NEUROPHYSIOL, V119, P1002, DOI 10.1016/j.clinph.2008.01.013
Collins AL, 2006, NEUROGENETICS, V7, P167, DOI 10.1007/s10048-006-0045-1
Constantino JN, 2005, SOCIAL RESPONSIVENES
de Jongh A, 2003, NEUROIMAGE, V20, P2291, DOI 10.1016/j.neuroimage.2003.07.030
DeLorey TM, 2008, BEHAV BRAIN RES, V187, P207, DOI 10.1016/j.bbr.2007.09.009
Dumont GJH, 2005, BRIT J CLIN PHARMACO, V59, P495, DOI 10.1111/j.1365-2125.2005.02342.x
Fisch B. J., 1999, FISCH SPEHLMANNS EEG
Fries P, 2005, TRENDS COGN SCI, V9, P474, DOI 10.1016/j.tics.2005.08.011
Geisler C, 2005, J NEUROPHYSIOL, V94, P4344, DOI 10.1152/jn.00510.2004
Hensch TK, 2005, NAT REV NEUROSCI, V6, P877, DOI 10.1038/nrn1787
Huang MX, 2009, J NEUROTRAUM, V26, P1213, DOI 10.1089/neu.2008.0672
Hughes JR, 2008, EPILEPSY BEHAV, V13, P25, DOI [10.1016/j.yebeh.2008.01.011, 10.1016/j.yebeh.2008.01.01]
Hughes SW, 2005, NEUROSCIENTIST, V11, P357, DOI 10.1177/1073858405277450
Iacoboni M, 2004, NEUROIMAGE, V21, P1167, DOI 10.1016/j.neuroimage.2003.11.013
Jokisch D, 2007, J NEUROSCI, V27, P3244, DOI 10.1523/JNEUROSCI.5399-06.2007
Kennedy DP, 2006, P NATL ACAD SCI USA, V103, P8275, DOI 10.1073/pnas.0600674103
Klimesch W, 1999, BRAIN RES REV, V29, P169, DOI 10.1016/S0165-0173(98)00056-3
Laufs H, 2003, P NATL ACAD SCI USA, V100, P11053, DOI 10.1073/pnas.1831638100
Levitt P, 2004, TRENDS NEUROSCI, V27, P400, DOI 10.1016/j.tins.2004.05.008
Levitt P, 2005, EPILEPSIA, V46, P22, DOI 10.1111/j.1528-1167.2005.00305.x
Lewine JD, 1999, PEDIATRICS, V104, P405, DOI 10.1542/peds.104.3.405
Loo SK, 1999, BIOL PSYCHIAT, V45, P1657, DOI 10.1016/S0006-3223(98)00250-9
Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
Lorincz ML, 2009, NEURON, V63, P683, DOI 10.1016/j.neuron.2009.08.012
Murias M, 2007, BIOL PSYCHIAT, V62, P270, DOI 10.1016/j.biopsych.2006.11.012
O'Connor SC, 2005, J THEOR BIOL, V233, P271, DOI 10.1016/j.jtbi.2004.10.009
Orekhova EV, 2007, BIOL PSYCHIAT, V62, P1022, DOI 10.1016/j.biopsych.2006.12.029
Peelen MV, 2010, J NEUROSCI, V30, P10127, DOI 10.1523/JNEUROSCI.2161-10.2010
Raichle ME, 2001, P NATL ACAD SCI USA, V98, P676, DOI 10.1073/pnas.98.2.676
Ramoz N, 2004, AM J PSYCHIAT, V161, P662, DOI 10.1176/appi.ajp.161.4.662
Roberts T. P. L., 2009, FUNCTIONAL NEUROIMAG
Roberts TPL, 2010, AUTISM RES, V3, P8, DOI 10.1002/aur.111
Rockstroh BS, 2007, BMC PSYCHIATRY, V7, DOI 10.1186/1471-244X-7-44
Rubenstein J. L. R., 2010, J CHILD PSYCHOL PSYC
Rubenstein JLR, 2003, GENES BRAIN BEHAV, V2, P255, DOI 10.1046/j.1601-183X.2003.00037.x
Rutter M., 2003, SOCIAL COMMUNICATION
SALMELIN R, 1994, ELECTROEN CLIN NEURO, V91, P237, DOI 10.1016/0013-4694(94)90187-2
Scharfman HE, 2007, CURR NEUROL NEUROSCI, V7, P348, DOI 10.1007/s11910-007-0053-z
Scherg M, 2002, J CLIN NEUROPHYSIOL, V19, P91, DOI 10.1097/00004691-200203000-00001
Sohal VS, 2009, NATURE, V459, P698, DOI 10.1038/nature07991
TallonBaudry C, 1997, J NEUROSCI, V17, P722
Uhlhaas Peter J, 2006, Neuron, V52, P155, DOI 10.1016/j.neuron.2006.09.020
Uhlhaas PJ, 2011, PROG BIOPHYS MOL BIO, V105, P14, DOI 10.1016/j.pbiomolbio.2010.10.004
Venables NC, 2009, SCHIZOPHRENIA BULL, V35, P826, DOI 10.1093/schbul/sbn021
Wang XJ, 2010, PHYSIOL REV, V90, P1195, DOI 10.1152/physrev.00035.2008
Wechsler D., 2003, WECHSLER INTELLIGENC
Whittington MA, 2000, INT J PSYCHOPHYSIOL, V38, P315, DOI 10.1016/S0167-8760(00)00173-2
Willoughby JO, 2003, J NEUROL NEUROSUR PS, V74, P51, DOI 10.1136/jnnp.74.1.51
NR 60
TC 19
Z9 20
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD SEP
PY 2012
VL 42
IS 9
BP 1884
EP 1894
DI 10.1007/s10803-011-1431-6
PG 11
WC Psychology, Developmental
SC Psychology
GA 992XT
UT WOS:000307815100012
PM 22207057
ER
PT J
AU Locke, J
Rotheram-Fuller, E
Kasari, C
AF Locke, Jill
Rotheram-Fuller, Erin
Kasari, Connie
TI Exploring the Social Impact of Being a Typical Peer Model for Included
Children with Autism Spectrum Disorder
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Peer models; Autism; Social networks
ID SKILLS INTERVENTIONS; YOUNG-CHILDREN; INCLUSION; CLASSROOMS; NETWORKS;
RECOMMENDATIONS; INVOLVEMENT; LONELINESS; FRIENDSHIP; ATTITUDES
AB This study examined the social impact of being a typical peer model as part of a social skills intervention for children with autism spectrum disorder (ASD). Participants were drawn from a randomized-controlled-treatment trial that examined the effects of targeted interventions on the social networks of 60 elementary-aged children with ASD. Results demonstrated that typical peer models had higher social network centrality, received friendships, friendship quality, and less loneliness than non-peer models. Peer models were also more likely to be connected with children with ASD than non-peer models at baseline and exit. These results suggest that typical peers can be socially connected to children with ASD, as well as other classmates, and maintain a strong and positive role within the classroom.
C1 [Locke, Jill] Univ Penn, Sch Med, Ctr Mental Hlth Policy & Serv Res, Philadelphia, PA 19104 USA.
[Locke, Jill] Childrens Hosp Philadelphia, Ctr Autism Res, Philadelphia, PA 19104 USA.
[Rotheram-Fuller, Erin] Temple Univ, Philadelphia, PA 19122 USA.
[Kasari, Connie] Univ Calif Los Angeles, Grad Sch Educ & Informat Studies, Los Angeles, CA USA.
RP Locke, J (reprint author), 3535 Market St,3rd Floor, Philadelphia, PA 19104 USA.
EM jlocke@upenn.edu
CR Bass JD, 2007, PSYCHOL SCHOOLS, V44, P727, DOI 10.1002/pits.20261
Bauminger N, 2000, CHILD DEV, V71, P447, DOI 10.1111/1467-8624.00156
Bellini S, 2007, REM SPEC EDUC, V28, P153, DOI 10.1177/07419325070280030401
BUKOWSKI WM, 1994, J SOC PERS RELAT, V11, P471, DOI 10.1177/0265407594113011
Cairns R. B., 1990, IDENTIFYING SO UNPUB
Cairns R. B., 1994, LIFELINES RISKS PATH
CAIRNS RB, 1988, DEV PSYCHOL, V24, P815, DOI 10.1037/0012-1649.24.6.815
Campbell JM, 2009, J AUTISM DEV DISORD, V39, P1359, DOI 10.1007/s10803-009-0738-z
Campbell JM, 2005, J DEV PHYS DISABIL, V17, P281, DOI 10.1007/s10882-005-4386-8
Chamberlain B, 2007, J AUTISM DEV DISORD, V37, P230, DOI 10.1007/s10803-006-0164-4
Church C., 2000, FOCUS AUTISM OTHER D, V15, P12, DOI DOI 10.1177/108835760001500102
Farmer TW, 1996, EXCEPT CHILDREN, V62, P431
Ferraioli S. J., 2011, J CONTEMP PSYCHOTHER, V41, P19, DOI [10.1007/s10879-010-9156-y, DOI 10.1007/S10879-010-9156-Y]
HARING TG, 1992, J APPL BEHAV ANAL, V25, P319, DOI 10.1901/jaba.1992.25-319
Hoza B, 2000, J CLIN CHILD PSYCHOL, V29, P119, DOI 10.1207/S15374424jccp2901_12
Jackson JN, 2009, J AUTISM DEV DISORD, V39, P269, DOI 10.1007/s10803-008-0623-1
Jones CD, 2004, TOP EARLY CHILD SPEC, V24, P187, DOI 10.1177/02711214040240040101
Jung S, 2008, J EARLY INTERVENTION, V30, P163, DOI 10.1177/1053815108317970
Kamps D., 1997, J BEHAV ED, V7, P335, DOI 10.1023/A:1022879607019
Kasari C., J CHILD PSY IN PRESS
Kasari C, 1999, J AUTISM DEV DISORD, V29, P297, DOI 10.1023/A:1022159302571
Kasari C, 2011, J AUTISM DEV DISORD, V41, P533, DOI 10.1007/s10803-010-1076-x
Kasari C., 2007, CLIN MANUAL TREATMEN, P235
Laushey KM, 2000, J AUTISM DEV DISORD, V30, P183, DOI 10.1023/A:1005558101038
McConnell SR, 2002, J AUTISM DEV DISORD, V32, P351, DOI 10.1023/A:1020537805154
Ochs E, 2001, SOC DEV, V10, P399, DOI 10.1111/1467-9507.00172
Owen-DeSchryver JS, 2008, FOCUS AUTISM DEV DIS, V23, P15, DOI 10.1177/1088357608314370
Pierce K, 1997, J APPL BEHAV ANAL, V30, P157, DOI 10.1901/jaba.1997.30-157
Prendeville J., 2005, SEMINARS SPEECH LANG, V27, P32
Rao PA, 2008, J AUTISM DEV DISORD, V38, P353, DOI 10.1007/s10803-007-0402-4
Reiter S, 2007, AUTISM, V11, P321, DOI 10.1177/1362361307078130
Roeyers H, 1996, J AUTISM DEV DISORD, V26, P303, DOI 10.1007/BF02172476
Rotheram-Fuller E, 2010, J CHILD PSYCHOL PSYC, V51, P1227, DOI 10.1111/j.1469-7610.2010.02289.x
SAINATO DM, 1992, J APPL BEHAV ANAL, V25, P127, DOI 10.1901/jaba.1992.25-127
Symes W, 2010, SCHOOL PSYCHOL INT, V31, P478, DOI 10.1177/0143034310382496
Williams White Susan, 2007, J Autism Dev Disord, V37, P1858, DOI 10.1007/s10803-006-0320-x
NR 36
TC 4
Z9 4
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD SEP
PY 2012
VL 42
IS 9
BP 1895
EP 1905
DI 10.1007/s10803-011-1437-0
PG 11
WC Psychology, Developmental
SC Psychology
GA 992XT
UT WOS:000307815100013
PM 22215436
ER
PT J
AU Ben-Sasson, A
Carter, AS
AF Ben-Sasson, Ayelet
Carter, Alice S.
TI The Application of the First Year Inventory for ASD Screening in Israel
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism; ASD; Community Screening; Infant
ID PERVASIVE DEVELOPMENTAL DISORDERS; AUTISM SPECTRUM DISORDERS;
CROSS-CULTURAL ADAPTATION; EPIDEMIOLOGIC PERSPECTIVE; CHILDREN;
INSTRUMENT; DIAGNOSIS; INFANTS; AGE
AB This study was designed to examine the generalizability and validity of the First Year Inventory (FYI) in Israel. Parents completed the FYI about their 12-month-olds (N = 471). Up to one month later, 17 at-risk and 38 non-risk infants participated in an assessment in which the Autism Observation Scale for Infants (AOSI) and the Mullen Scales of Early Learning (MSEL) were administered. Using the original FYI 95th percentile cutoff the risk rate in this Israeli sample was 11%. The current sample's 95th percentile cutoff was 4.8 points higher than the original US sample. Infants in the risk group obtained significantly higher AOSI scores and lower MSEL scores. Socio-demographic factors may influence risk results suggesting the need to adapt screening to serve all.
C1 [Ben-Sasson, Ayelet] Univ Haifa, Dept Occupat Therapy, IL-31905 Haifa, Israel.
[Carter, Alice S.] Univ Massachusetts, Dept Psychol, Boston, MA 02125 USA.
RP Ben-Sasson, A (reprint author), Univ Haifa, Dept Occupat Therapy, IL-31905 Haifa, Israel.
EM asasson@univ.haifa.ac.il
CR Al- Qabandi M., 2011, PEDIATRICS, V128, P1098
Baird G, 2000, J AM ACAD CHILD PSY, V39, P694, DOI 10.1097/00004583-200006000-00007
Baranek GT, 1999, J AUTISM DEV DISORD, V29, P213, DOI 10.1023/A:1023080005650
Baranek GT, 2003, 1 YEAR INVENTORY FYI
Beaton DE, 2000, SPINE, V25, P3186, DOI 10.1097/00007632-200012150-00014
Bryson SE, 2008, J AUTISM DEV DISORD, V38, P731, DOI 10.1007/s10803-007-0440-y
Bryson SE, 2007, J AUTISM DEV DISORD, V37, P12, DOI 10.1007/s10803-006-0328-2
Canal-Bedia R, 2011, J AUTISM DEV DISORD, V41, P1342, DOI 10.1007/s10803-010-1163-z
Chakrabarti S, 2005, AM J PSYCHIAT, V162, P1133, DOI 10.1176/appi.ajp.162.6.1133
Coonrod EE, 2004, INFANT YOUNG CHILD, V17, P258
Daley Tamara C, 2002, TRANSCULT PSYCHIATRY, V39, P531, DOI [10.1177/136346150203900409, DOI 10.1177/136346150203900409]
Davidovitch M, 2001, ISRAEL MED ASSOC J, V3, P188
Dawson G., 2010, PEDIATRICS, V125, P17
Dawson G, 2008, DEV PSYCHOPATHOL, V20, P775, DOI 10.1017/S0954579408000370
Dereu M, 2010, J AUTISM DEV DISORD, V40, P1247, DOI 10.1007/s10803-010-0984-0
Dietz C, 2006, J AUTISM DEV DISORD, V36, P713, DOI 10.1007/s10803-006-0114-1
Engel-Yeger B, 2010, RES DEV DISABIL, V31, P87, DOI 10.1016/j.ridd.2009.08.001
Filipek PA, 2000, NEUROLOGY, V55, P468
Fombonne E, 2003, J AUTISM DEV DISORD, V33, P365, DOI 10.1023/A:1025054610557
Inada N, 2010, RES AUTISM SPECT DIS, V4, P605, DOI 10.1016/j.rasd.2009.12.003
Johnson CP, 2007, PEDIATRICS, V120, P1183, DOI 10.1542/peds.2007-2361
Miller JS, 2011, PEDIATRICS, V127, P866, DOI 10.1542/peds.2010-0136
Mullen E, 1995, MULLEN SCALES EARLY
Muratori F., 2008, INT M AUT RES LOND
Neuman Ariela, 2004, Occup Ther Int, V11, P112, DOI 10.1002/oti.201
Perera H, 2009, J TROP PEDIATRICS, V55, P402, DOI 10.1093/tropej/fmp031
Pierce K, 2011, J PEDIATR-US, V159, P458, DOI 10.1016/j.jpeds.2011.02.036
Reznick JS, 2007, J AUTISM DEV DISORD, V37, P1691, DOI 10.1007/s10803-006-0303-y
Robins DL, 2001, J AUTISM DEV DISORD, V31, P131, DOI 10.1023/A:1010738829569
Stone WL, 2000, J AUTISM DEV DISORD, V30, P607, DOI 10.1023/A:1005647629002
The Central Bureau of Statistics and Ministry of Education Israel, 2007, REP CHILDR DAYC 2007
Tirosh E, 2003, J CHILD NEUROL, V18, P748, DOI 10.1177/08830738030180110901
van Widenfelt BM, 2005, CLIN CHILD FAM PSYCH, V8, P135, DOI 10.1007/s10567-005-4752-1
Weissblai I., 2005, PARTICIPATION WOMEN
Zwaigenbaum L, 2005, INT J DEV NEUROSCI, V23, P143, DOI 10.1016/j.ijdevneu.2004.05.001
NR 35
TC 4
Z9 4
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD SEP
PY 2012
VL 42
IS 9
BP 1906
EP 1916
DI 10.1007/s10803-011-1436-1
PG 11
WC Psychology, Developmental
SC Psychology
GA 992XT
UT WOS:000307815100014
PM 22234796
ER
PT J
AU Kaartinen, M
Puura, K
Makela, T
Rannisto, M
Lemponen, R
Helminen, M
Salmelin, R
Himanen, SL
Hietanen, JK
AF Kaartinen, Miia
Puura, Kaija
Makela, Tiina
Rannisto, Mervi
Lemponen, Riina
Helminen, Mika
Salmelin, Raili
Himanen, Sari-Leena
Hietanen, Jari K.
TI Autonomic Arousal to Direct Gaze Correlates with Social Impairments
Among Children with ASD
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism; Eye contact; Gaze; Skin conductance; Social skills
ID EYE CONTACT; FACE RECOGNITION; JOINT ATTENTION; APPROACH BEHAVIOR;
SKIN-CONDUCTANCE; AUTISM; SPECTRUM; COMMUNICATION; COMPETENCE; AVOIDANCE
AB The present study investigated whether autonomic arousal to direct gaze is related to social impairments among children with autism spectrum disorder (ASD). Arousal was measured through skin conductance responses (SCR) while the participants (15 children with ASD and 16 control children) viewed a live face of another person. Impairments in social skills was assessed with the Developmental, Dimensional and Diagnostic Interview. The level of arousal enhancement to direct gaze in comparison to arousal to faces with averted gaze or closed eyes was positively associated with impairments in social skills (use of language and other social communication skills and use of gesture and non-verbal play) among children with ASD. There was no similar association among children without ASD. The role of arousal-related factors in influencing eye contact behaviour in ASD is discussed.
C1 [Kaartinen, Miia; Puura, Kaija; Salmelin, Raili] Tampere Univ Hosp, Dept Child Psychiat, Tampere 33521, Finland.
[Kaartinen, Miia; Puura, Kaija; Salmelin, Raili] Univ Tampere, Tampere 33521, Finland.
[Makela, Tiina; Rannisto, Mervi; Hietanen, Jari K.] Univ Tampere, Human Informat Proc Lab, Sch Social Sci & Humanities, Tampere 33014, Finland.
[Lemponen, Riina; Helminen, Mika; Salmelin, Raili] Univ Tampere, Tampere Sch Hlth Sci, Tampere 33014, Finland.
[Helminen, Mika] Pirkanmaa Hosp Dist, Ctr Sci, Tampere 33521, Finland.
[Himanen, Sari-Leena] Tampere Univ Hosp, Dept Clin Neurophysiol, Tampere 33521, Finland.
RP Kaartinen, M (reprint author), Tampere Univ Hosp, Dept Child Psychiat, Box 2000, Tampere 33521, Finland.
EM miia.kaartinen@fimnet.fi; jari.hietanen@uta.fi
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
Andreassi J. L., 2006, PSYCHOPHYSIOLOGY HUM
Baron M. J., 2001, QUEENS VIDEO CODER
Batki A, 2000, INFANT BEHAV DEV, V23, P223, DOI 10.1016/S0163-6383(01)00037-6
Behrmann M, 2006, NEUROPSYCHOLOGIA, V44, P110, DOI 10.1016/j.neuropsychologia.2005.04.002
BRADLEY MM, 1994, J BEHAV THER EXP PSY, V25, P49, DOI 10.1016/0005-7916(94)90063-9
Charman T, 2011, BRAIN RES, V1380, P10, DOI 10.1016/j.brainres.2010.10.075
CHERULNIK PD, 1978, J SOC PSYCHOL, V104, P263
Corden B, 2008, NEUROPSYCHOLOGIA, V46, P137, DOI 10.1016/j.neuropsychologia.2007.08.005
Dalton KM, 2005, NAT NEUROSCI, V8, P519, DOI 10.1038/nn1421
Dawson G, 2005, DEV NEUROPSYCHOL, V27, P403, DOI 10.1207/s15326942dn2703_6
Deruelle C, 2004, J AUTISM DEV DISORD, V34, P199, DOI 10.1023/B:JADD.0000022610.09668.4c
Farroni T, 2006, J EXP CHILD PSYCHOL, V95, P298, DOI 10.1016/j.jecp.2006.08.001
George N, 2008, NEUROPHYSIOL CLIN, V38, P197, DOI 10.1016/j.neucli.2008.03.001
Hietanen JK, 2008, NEUROPSYCHOLOGIA, V46, P2423, DOI 10.1016/j.neuropsychologia.2008.02.029
HUTT C, 1966, BEHAV SCI, V11, P346, DOI 10.1002/bs.3830110504
Jones W, 2008, ARCH GEN PSYCHIAT, V65, P946, DOI 10.1001/archpsyc.65.8.946
Joseph RM, 2008, J INT NEUROPSYCH SOC, V14, P947, DOI 10.1017/S1355617708081344
Joseph RM, 2003, J CHILD PSYCHOL PSYC, V44, P529, DOI 10.1111/1469-7610.00142
Keller H, 1993, Acta Paedopsychiatr, V56, P31
KLEINKE CL, 1986, PSYCHOL BULL, V100, P78, DOI 10.1037//0033-2909.100.1.78
Klin A, 2002, ARCH GEN PSYCHIAT, V59, P809, DOI 10.1001/archpsyc.59.9.809
Kylliainen A, 2006, J AUTISM DEV DISORD, V36, P517, DOI 10.1007/s10803-006-0091-4
Langley R, 1979, PRACTICAL STAT SIMPL
Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
LYKKEN DT, 1971, PSYCHOPHYSIOLOGY, V8, P656, DOI 10.1111/j.1469-8986.1971.tb00501.x
MORTON J, 1991, PSYCHOL REV, V98, P164, DOI 10.1037//0033-295X.98.2.164
Mundy P, 2007, CHILD DEV, V78, P938, DOI 10.1111/j.1467-8624.2007.01042.x
MUNDY P, 1995, DEV PSYCHOPATHOL, V7, P63
Nacewicz BM, 2006, ARCH GEN PSYCHIAT, V63, P1417, DOI 10.1001/archpsyc.63.12.1417
Nummenmaa L, 2010, CEREB CORTEX, V20, P1780, DOI 10.1093/cercor/bhp244
OSTERLING J, 1994, J AUTISM DEV DISORD, V24, P247, DOI 10.1007/BF02172225
Ponkanen LM, 2011, SOC COGN AFFECT NEUR, V6, P486, DOI 10.1093/scan/nsq068
Ponkanen LM, 2008, NEUROREPORT, V19, P497, DOI 10.1097/WNR.0b013e3282f7c4d3
ROBSON KS, 1969, CHILD DEV, V40, P619, DOI 10.1111/j.1467-8624.1969.tb04526.x
Senju A, 2009, TRENDS COGN SCI, V13, P127, DOI 10.1016/j.tics.2008.11.009
Skuse D., 2003, CHILD ADOLESCENT MEN, V8, P50, DOI 10.1111/1475-3588.00047
Skuse D, 2004, J AM ACAD CHILD PSY, V43, P548, DOI 10.1097/00004583-200405000-00008
Spezio ML, 2007, J AUTISM DEV DISORD, V37, P929, DOI 10.1007/s10803-006-0232-9
Stone WL, 1997, J AUTISM DEV DISORD, V27, P677, DOI 10.1023/A:1025854816091
Strid K, 2006, INFANT BEHAV DEV, V29, P545, DOI 10.1016/j.infbeh.2006.07.002
TINBERGE.N, 1974, SCIENCE, V185, P20, DOI 10.1126/science.185.4145.20
Van Hecke AV, 2007, CHILD DEV, V78, P53
von dem Hagen EAH, 2011, CEREB CORTEX, V21, P493, DOI 10.1093/cercor/bhq062
Zwaigenbaum L, 2005, INT J DEV NEUROSCI, V23, P143, DOI 10.1016/j.ijdevneu.2004.05.001
NR 45
TC 6
Z9 6
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD SEP
PY 2012
VL 42
IS 9
BP 1917
EP 1927
DI 10.1007/s10803-011-1435-2
PG 11
WC Psychology, Developmental
SC Psychology
GA 992XT
UT WOS:000307815100015
PM 22215435
ER
PT J
AU Rahbar, MH
Samms-Vaughan, M
Loveland, KA
Pearson, DA
Bressler, J
Chen, ZX
Ardjomand-Hessabi, M
Shakespeare-Pellington, S
Grove, ML
Beecher, C
Bloom, K
Boerwinkle, E
AF Rahbar, Mohammad H.
Samms-Vaughan, Maureen
Loveland, Katherine A.
Pearson, Deborah A.
Bressler, Jan
Chen, Zhongxue
Ardjomand-Hessabi, Manouchehr
Shakespeare-Pellington, Sydonnie
Grove, Megan L.
Beecher, Compton
Bloom, Kari
Boerwinkle, Eric
TI Maternal and Paternal Age are Jointly Associated with Childhood Autism
in Jamaica
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism spectrum disorders; Maternal age; Paternal age; Multivariate
General Linear Models; Multicollinearity
ID OLDER REPRODUCTIVE AGE; SPECTRUM DISORDERS; INFANTILE-AUTISM;
RISK-FACTORS; PERINATAL FACTORS; PARENTAL AGE; POPULATION; BIRTH;
PARAMETERIZATION; CHILDREN
AB Several studies have reported maternal and paternal age as risk factors for having a child with Autism Spectrum Disorder (ASD), yet the results remain inconsistent. We used data for 68 age- and sex-matched case-control pairs collected from Jamaica. Using Multivariate General Linear Models (MGLM) and controlling for parity, gestational age, and parental education, we found a significant (p < 0.0001) joint effect of parental ages on having children with ASD indicating an adjusted mean paternal age difference between cases and controls of [5.9 years; 95% CI (2.6, 9.1)] and a difference for maternal age of [6.5 years; 95% CI (4.0, 8.9)]. To avoid multicollinearity in logistic regression, we recommend joint modeling of parental ages as a vector of outcome variables using MGLM.
C1 [Rahbar, Mohammad H.] Univ Texas Hlth Sci Ctr Houston UThlth, CCTS, BERD Core, Houston, TX 77030 USA.
[Rahbar, Mohammad H.] Univ Texas Hlth Sci Ctr Houston UThlth, Div Epidemiol Human Genet & Environm Sci EHGES, Sch Publ Hlth, Houston, TX 77030 USA.
[Samms-Vaughan, Maureen; Shakespeare-Pellington, Sydonnie] Univ W Indies, Dept Child Hlth, Kingston 7, Jamaica.
[Loveland, Katherine A.] UTHlth, UTHlth Med Sch, Dept Psychiat & Behav Sci, Houston, TX 77054 USA.
[Loveland, Katherine A.] UTHlth, Dept Psychiat & Behav Sci, CLASS Clin, Houston, TX 77054 USA.
[Loveland, Katherine A.] UTHlth, Ctr Excellence Dev & Psychopathol, Houston, TX 77054 USA.
[Pearson, Deborah A.] UTHlth, UTHlth Med Sch, Dept Psychiat & Behav Sci, Div Child & Adolescent Psychiat, Houston, TX 77054 USA.
[Bressler, Jan; Grove, Megan L.; Boerwinkle, Eric] UTHlth, Sch Publ Hlth, Ctr Human Genet, Houston, TX 77030 USA.
RP Rahbar, MH (reprint author), Univ Texas Hlth Sci Ctr Houston UThlth, CCTS, BERD Core, 6410 Fannin St,UT Profess Bldg,Suite 1100-05, Houston, TX 77030 USA.
EM Mohammad.H.Rahbar@uth.tmc.edu; msamms@cwjamaica.com;
Katherine.A.Loveland@uth.tmc.edu; Deborah.A.Pearson@uth.tmc.edu;
Jan.Bressler@uth.tmc.edu; sydonniesp@gmail.com;
Megan.L.Grove@uth.tmc.edu; Eric.Boerwinkle@uth.tmc.edu
RI Chen, Zhongxue/K-1372-2013
OI Chen, Zhongxue/0000-0003-2537-7843
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
[Anonymous], 2009, MMWR SURVEILL SUMM, V58, P1
Beebe Kathleen R, 2005, AWHONN Lifelines, V9, P394, DOI 10.1177/1091592305283142
Bilder D, 2009, PEDIATRICS, V123, P1293, DOI 10.1542/peds.2008-0927
Blaxill MF, 2004, PUBLIC HEALTH REP, V119, P536, DOI 10.1016/j.phr.2004.09.003
Breslow NE, 1980, IARC SCI PUBLICATION, V32
Chakrabarti S, 2005, AM J PSYCHIAT, V162, P1133, DOI 10.1176/appi.ajp.162.6.1133
Creinin MD, 2009, OBSTET GYNECOL, V113, P709, DOI 10.1097/AOG.0b013e3181988f8f
Croen LA, 2002, J AUTISM DEV DISORD, V32, P217, DOI 10.1023/A:1015405914950
Croen LA, 2007, ARCH PEDIAT ADOL MED, V161, P334, DOI 10.1001/archpedi.161.4.334
Durkin MS, 2008, AM J EPIDEMIOL, V168, P1268, DOI 10.1093/aje/kwn250
Durkin MS, 2010, AM J PUBLIC HEALTH, V100, P389, DOI 10.2105/AJPH.2009.184101
Fraga MF, 2007, TRENDS GENET, V23, P413, DOI 10.1016/j.tig.2007.05.008
Gabis L, 2010, PEDIATR NEUROL, V43, P300, DOI 10.1016/j.pediatrneurol.2010.05.022
Gardener H, 2009, BRIT J PSYCHIAT, V195, P7, DOI 10.1192/bjp.bp.108.051672
GILLBERG C, 1980, J AUTISM DEV DISORD, V10, P293, DOI 10.1007/BF02408288
Glasson EJ, 2004, ARCH GEN PSYCHIAT, V61, P618, DOI 10.1001/archpsyc.61.6.618
Golding J, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009939
GORDON RA, 1968, AM J SOCIOL, V73, P592, DOI 10.1086/224533
Grether JK, 2009, AM J EPIDEMIOL, V170, P1118, DOI 10.1093/aje/kwp247
Hultman CM, 2011, MOL PSYCHIATR, V16, P1203, DOI 10.1038/mp.2010.121
Johnson R. A., 2007, APPL MULTIVARIATE ST
JONES MB, 1988, J AUTISM DEV DISORD, V18, P31, DOI 10.1007/BF02211816
King MD, 2009, AM J PUBLIC HEALTH, V99, P1673, DOI 10.2105/AJPH.2008.149021
King MD, 2010, AM J PUBLIC HEALTH, V100, P390, DOI 10.2105/AJPH.2009.184168
Larsson HJ, 2005, AM J EPIDEMIOL, V161, P916, DOI 10.1093/aje/kwi123
Lord C, 1997, J AUTISM DEV DISORD, V27, P501, DOI 10.1023/A:1025873925661
Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
Lord C., 2002, AUTISM DIAGNOSTIC OB
MacKay DF, 2010, PLOS MED, V7, DOI 10.1371/journal.pmed.1000289
MOURIDSEN SE, 1993, J AUTISM DEV DISORD, V23, P387, DOI 10.1007/BF01046227
Muller KE, 2006, LINEAR MODEL THEORY
Mulligan A, 2009, IRISH J MED SCI, V178, P193, DOI 10.1007/s11845-008-0184-5
Opara EI, 2007, BJOG-INT J OBSTET GY, V114, P1295, DOI 10.1111/j.1471-0528.2007.01435.x
Reichenberg A, 2006, ARCH GEN PSYCHIAT, V63, P1026, DOI 10.1001/archpsyc.63.9.1026
Rutter M., 2003, SCQ SOCIAL OCMMUNICA
Rutter M., 2003, AUTISM DIAGNOSTIC IN
Saha S, 2009, PLOS MED, V6, DOI 10.1371/journal.pmed.1000040
Saha S, 2009, SCHIZOPHR RES, V115, P130, DOI 10.1016/j.schres.2009.09.012
SAS Institute Inc, 2008, SAS 9 2
Sasanfar R, 2010, MOL AUTISM, V1, DOI 10.1186/2040-2392-1-2
Schellingerhout JM, 2009, J CLIN EPIDEMIOL, V62, P868, DOI 10.1016/j.jclinepi.2008.10.010
SCHOPLER E, 1980, J AUTISM DEV DISORD, V10, P91, DOI 10.1007/BF02408436
Selkirk CG, 2009, J GENET COUNS, V18, P507, DOI 10.1007/s10897-009-9233-0
Shelton JF, 2010, AUTISM RES, V3, P30, DOI 10.1002/aur.116
TSAI LY, 1983, J AUTISM DEV DISORD, V13, P57, DOI 10.1007/BF01531359
Tsuchiya KJ, 2008, BRIT J PSYCHIAT, V193, P316, DOI 10.1192/bjp.bp.107.045120
Zhang X, 2010, J AUTISM DEV DISORD, V40, P1311, DOI 10.1007/s10803-010-0992-0
Zhao X, 2007, P NATL ACAD SCI USA, V104, P12831, DOI 10.1073/pnas.0705803104
NR 49
TC 9
Z9 9
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD SEP
PY 2012
VL 42
IS 9
BP 1928
EP 1938
DI 10.1007/s10803-011-1438-z
PG 11
WC Psychology, Developmental
SC Psychology
GA 992XT
UT WOS:000307815100016
PM 22230961
ER
PT J
AU Barbaro, J
Dissanayake, C
AF Barbaro, Josephine
Dissanayake, Cheryl
TI Developmental Profiles of Infants and Toddlers with Autism Spectrum
Disorders Identified Prospectively in a Community-Based Setting
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism spectrum disorders; Developmental profiles; Mullen; Infants;
Toddlers; Prospective; Red flags; Receptive language
ID EARLY LANGUAGE; COMMUNICATION DEVELOPMENT; PRESCHOOL-CHILDREN;
YOUNG-CHILDREN; FOLLOW-UP; 2ND YEAR; AGE; STABILITY; DIAGNOSIS; OUTCOMES
AB This prospective, longitudinal, study charted the developmental profiles of young children with Autism Spectrum Disorders (ASD) identified through routine developmental surveillance. 109 children with Autistic Disorder (AD), 'broader' ASD, and developmental and/or language delays (DD/LD) were assessed using the Mullen Scales of Early Learning (MSEL) at 12-months (n = 10 assessments), 18-months (n = 45 assessments), and 24-months (n = 99 assessments). The children with AD performed most poorly, overall, than the ASD and DD/LD groups on the MSEL. Furthermore, the children with AD/ASD displayed an uneven cognitive profile, with poorer performance on verbal (particularly receptive language) relative to nonverbal skills. There was also evidence of developmental slowing in verbal skills from 18- to 24-months for children on the spectrum, especially those with AD. Given that the poor receptive, relative to expressive, language profile emerges very early in life for children with AD/ASD, this cognitive profile may serve as an additional red flag to social attention and communication deficits. Receptive language should therefore be stringently monitored in any developmental surveillance program for autism spectrum disorders in the second year of life.
C1 [Barbaro, Josephine; Dissanayake, Cheryl] La Trobe Univ, Sch Psychol Sci, Olga Tennison Autism Res Ctr, Bundoora, Vic 3083, Australia.
RP Barbaro, J (reprint author), La Trobe Univ, Sch Psychol Sci, Olga Tennison Autism Res Ctr, Bundoora, Vic 3083, Australia.
EM j.barbaro@latrobe.edu.au
CR Akshoomoff N, 2006, CHILD NEUROPSYCHOL, V12, P269, DOI 10.1080/09297040500473714
American Psychiatric Association, 2000, DIAGN STAT MAN MENT
Barbaro J., 2012, AUTISM IN PRESS
Barbaro J, 2010, J DEV BEHAV PEDIATR, V31, P376, DOI 10.1097/DBP.0b013e3181df7f3c
Barbaro J., 2010, J PEDIAT NURSING, V26, P334
Barbaro J, 2009, J DEV BEHAV PEDIATR, V30, P447, DOI 10.1097/DBP.0b013e3181ba0f9f
Bryson SE, 2007, J AUTISM DEV DISORD, V37, P12, DOI 10.1007/s10803-006-0328-2
Carter AS, 2007, J AUTISM DEV DISORD, V37, P86, DOI 10.1007/s10803-006-0331-7
Charman T, 2003, J CHILD LANG, V30, P213, DOI 10.1017/S0305000902005482
Charman T, 2005, J CHILD PSYCHOL PSYC, V46, P500, DOI 10.1111/j.1469-7610.2004.00377.x
Chawarska K, 2009, J CHILD PSYCHOL PSYC, V50, P1235, DOI 10.1111/j.1469-7610.2009.02101.x
Chawarska K, 2007, J CHILD PSYCHOL PSYC, V48, P128, DOI 10.1111/j.1469-7610.2006.01685.x
Childers D. O., 2006, NE FLORIDA MED, V57, P28
Coolican J, 2008, J AUTISM DEV DISORD, V38, P190, DOI 10.1007/s10803-007-0368-2
Dawson G, 2008, DEV PSYCHOPATHOL, V20, P775, DOI 10.1017/S0954579408000370
Eaves LC, 2004, J AUTISM DEV DISORD, V34, P367, DOI 10.1023/B:JADD.0000037414.33270.a8
Hobbs K, 2007, BIOL PSYCHIAT, V62, P1048, DOI 10.1016/j.biopsych.2007.03.020
Hudry K, 2010, INT J LANG COMM DIS, V45, P681, DOI 10.3109/13682820903461493
Jordan L. C., 2002, HARRIET LANE HDB MAN, P189
Joseph RM, 2002, J CHILD PSYCHOL PSYC, V43, P807, DOI 10.1111/1469-7610.00092
Kleinman JM, 2008, J AUTISM DEV DISORD, V38, P606, DOI 10.1007/s10803-007-0427-8
Landa R, 2006, J CHILD PSYCHOL PSYC, V47, P629, DOI 10.1111/j.1469-7610.2006.01531.x
Landa RJ, 2007, ARCH GEN PSYCHIAT, V64, P853, DOI 10.1001/archpsyc.64.7.853
Leekam S., 2007, NEW DEV AUTISM FUTUR, P236
Lord C., 1999, AUTISM DIAGNOSTIC OB
LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
Luyster RJ, 2008, J AUTISM DEV DISORD, V38, P1426, DOI 10.1007/s10803-007-0510-1
Mitchell S, 2006, J DEV BEHAV PEDIATR, V27, pS69, DOI 10.1097/00004703-200604002-00004
Mullen E, 1995, MULLEN SCALES EARLY
MUNDY P, 1990, J AUTISM DEV DISORD, V20, P115, DOI 10.1007/BF02206861
Ozonoff S, 2010, J AM ACAD CHILD PSY, V49, P256, DOI 10.1016/j.jaac.2009.11.009
Pandey J., 2008, DISS ABSTR INT B, V68, P5586
Paul R, 2008, AUTISM RES, V1, P97, DOI 10.1002/aur.12
Rogers SJ, 2008, J CLIN CHILD ADOLESC, V37, P8, DOI 10.1080/15374410701817808
Sebat J, 2007, SCIENCE, V316, P445, DOI 10.1126/science.1138659
Tabachnick B., 2007, USING MULTIVARIATE S, V5th
Thurm A, 2007, J AUTISM DEV DISORD, V37, P1721, DOI 10.1007/s10803-006-0300-1
Tomasello M, 2005, BEHAV BRAIN SCI, V28, P675, DOI 10.1017/S0140525X05000129
Turner LM, 2006, AUTISM, V10, P243, DOI 10.1177/1362361306063296
Ventola P, 2007, J AUTISM DEV DISORD, V37, P425, DOI 10.1007/s10803-006-0177-z
Weismer SE, 2010, J AUTISM DEV DISORD, V40, P1259, DOI 10.1007/s10803-010-0983-1
Wetherby AM, 2007, J AUTISM DEV DISORD, V37, P960, DOI 10.1007/s10803-006-0237-4
WING L, 1981, J AUTISM DEV DISORD, V11, P31, DOI 10.1007/BF01531339
Zhao X, 2007, P NATL ACAD SCI USA, V104, P12831, DOI 10.1073/pnas.0705803104
NR 45
TC 5
Z9 8
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD SEP
PY 2012
VL 42
IS 9
BP 1939
EP 1948
DI 10.1007/s10803-012-1441-z
PG 10
WC Psychology, Developmental
SC Psychology
GA 992XT
UT WOS:000307815100017
PM 22310906
ER
PT J
AU Witwer, AN
Lecavalier, L
Norris, M
AF Witwer, Andrea N.
Lecavalier, Luc
Norris, Megan
TI Reliability and Validity of the Children's Interview for Psychiatric
Syndromes-Parent Version in Autism Spectrum Disorders
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Structured interview; Autism spectrum disorder; Psychiatric disorder;
Validity; Reliability
ID PERVASIVE DEVELOPMENTAL DISORDERS; SYNDROMES CHIPS; ANXIETY SYMPTOMS;
VALIDATION; RATES
AB The Children's Interview for Psychiatric Syndromes-Parent Version (P-ChIPS) is a structured psychiatric interview designed to assess the presence of psychiatric disorders in children and adolescents. This study examined the reliability and validity of the P-ChIPS in 61 youngsters (6- to 17-years-old) with Autism Spectrum Disorders. Reliability analyses were conducted according to level of functioning and language level. Results indicated that interrater reliability values were largely in the good to excellent range. Concordance between the P-ChIPS and the Child and Adolescent Symptoms Inventory was fair for the majority of disorders. Percent overall agreement for most disorders was good, lending support to the validity of the P-ChIPS. The results of this study suggest that the P-ChIPS is appropriate for this population.
C1 [Witwer, Andrea N.; Lecavalier, Luc] Ohio State Univ, Dept Psychol, Nisonger Ctr, Columbus, OH 43210 USA.
[Witwer, Andrea N.; Lecavalier, Luc] Ohio State Univ, Dept Psychiat, Nisonger Ctr, Columbus, OH 43210 USA.
[Norris, Megan] Nationwide Childrens Hosp, Columbus, OH USA.
RP Witwer, AN (reprint author), Ohio State Univ, Dept Psychol, Nisonger Ctr, 371C McCampbell Hall,1581 Dodd Dr, Columbus, OH 43210 USA.
EM andrea.witwer@osumc.edu
CR Ambrosini PJ, 2000, J AM ACAD CHILD PSY, V39, P49, DOI 10.1097/00004583-200001000-00016
Bryson S. E., 2000, AUTISM, V4, P117, DOI DOI 10.1177/1362361300004002002
Cicchetti D. V., 1994, PSYCHOL ASSESSMENT, V6, P284, DOI [DOI 10.1037/1040-3590.6.4.284, 10.1037/1040-3590.6.4.284]
Cooray S., 2007, DIAGNOSTIC MANUAL IN, P317
Costello EJ, 2005, J AM ACAD CHILD PSY, V44, P972, DOI 10.1097/01.chi.0000172552.041596.6f
de Bruin EI, 2007, J AUTISM DEV DISORD, V37, P877, DOI 10.1007/s10803-006-0215-x
Findlay W. M., 2001, PSYCHOL ASSESSMENT, V13, P319
Fletcher R., 2007, DIAGNOSTIC MANUAL IN, P1
Fristad M. A., 1999, PARENT VERSION CHILD
Fristad MA, 1998, J CHILD ADOL PSYCHOP, V8, P221, DOI 10.1089/cap.1998.8.221
Gadow K. D., 2002, CHILD SYMPTOM INVENT
Gadow K. D., 1997, CHILD SYMPTOM INVENT
Gadow KD, 2008, J AUTISM DEV DISORD, V38, P1710, DOI 10.1007/s10803-008-0556-8
Gadow KD, 2006, J AUTISM DEV DISORD, V36, P271, DOI 10.1007/s10803-005-0060-3
Lecavalier L, 2006, J AUTISM DEV DISORD, V36, P1101, DOI 10.1007/s10803-006-0147-5
Lecavalier L, 2009, J AUTISM DEV DISORD, V39, P278, DOI 10.1007/s10803-008-0622-2
Leyfer OT, 2006, J AUTISM DEV DISORD, V36, P849, DOI 10.1007/s10803-006-0123-0
Muris P, 1998, J ANXIETY DISORD, V12, P387, DOI 10.1016/S0887-6185(98)00022-X
Puig-Antich J., 1978, SCHEDULE AFFECTIVE D
Roid G. H., 2003, STANFORD BINET INTEL
Rutter M., 2003, AUTISM DIAGNOSTIC IN
Simonoff E, 2008, J AM ACAD CHILD PSY, V47, P921, DOI 10.1097/CHI.0b013e318179964f
Sukhodolsky DG, 2008, J ABNORM CHILD PSYCH, V36, P117, DOI 10.1007/s10802-007-9165-9
Swenson LP, 2007, J AM ACAD CHILD PSY, V46, P1482, DOI 10.1097/chi.0b013e31814cef0e
Teare M, 1998, J CHILD ADOL PSYCHOP, V8, P205, DOI 10.1089/cap.1998.8.205
Tonge BJ, 2003, INT REV RES MENT RET, V26, P61, DOI 10.1016/S0074-7750(03)01002-4
VERDUCCI JS, 1988, J MULTIVARIATE ANAL, V27, P512, DOI 10.1016/0047-259X(88)90145-5
Weller EB, 2000, J AM ACAD CHILD PSY, V39, P76, DOI 10.1097/00004583-200001000-00019
Witwer AN, 2010, J DEV PHYS DISABIL, V22, P367, DOI 10.1007/s10882-010-9194-0
NR 29
TC 3
Z9 3
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD SEP
PY 2012
VL 42
IS 9
BP 1949
EP 1958
DI 10.1007/s10803-012-1442-y
PG 10
WC Psychology, Developmental
SC Psychology
GA 992XT
UT WOS:000307815100018
PM 22274777
ER
PT J
AU Kocovska, E
Biskupsto, R
Gillberg, IC
Ellefsen, A
Kampmann, H
Stora, T
Billstedt, E
Gillberg, C
AF Kocovska, Eva
Biskupsto, Rannva
Gillberg, I. Carina
Ellefsen, Asa
Kampmann, Hanna
Stora, Tormoour
Billstedt, Eva
Gillberg, Christopher
TI The Rising Prevalence of Autism: A Prospective Longitudinal Study in the
Faroe Islands
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism; Asperger's syndrome; Prevalence; Genetic isolate; Children;
Young adults; Females
ID COMMUNICATION DISORDERS; DIAGNOSTIC INTERVIEW; ASPERGER SYNDROME; TOTAL
POPULATION; SPECTRUM; DEFICITS
AB We have followed up a 2002 population study of autism prevalence in 15-24-year olds in the Faroe Islands. The rate of ASD grew significantly from 0.56% in 2002 to 0.94% in 2009. Although these results are within the range of typical findings from other studies, there were some interesting details. There were-in addition to 43 originally diagnosed cases in 2002-24 newly discovered cases in 2009 and nearly half of them were females. It is possible that unfamiliarity with the clinical presentation of autism in females have played a significant role in this context. There was diagnostic stability for the overall category of ASD over time in the group diagnosed in childhood (7-16) years, but considerable variability as regards diagnostic sub-groupings.
C1 [Kocovska, Eva] Univ Glasgow, Royal Hosp Sick Children, Inst Hlth & Wellbeing, Glasgow G3 8SJ, Lanark, Scotland.
[Gillberg, I. Carina; Billstedt, Eva; Gillberg, Christopher] Gillberg Neuropsychiat Ctr, SE-41119 Gothenburg, Sweden.
RP Kocovska, E (reprint author), Univ Glasgow, Royal Hosp Sick Children, Inst Hlth & Wellbeing, Caledonia House, Glasgow G3 8SJ, Lanark, Scotland.
EM eva.kocovska@glasgow.ac.uk
CR American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th
Baron-Cohen S, 2009, BRIT J PSYCHIAT, V194, P500, DOI 10.1192/bjp.bp.108.059345
Billstedt E, 2005, J AUTISM DEV DISORD, V35, P351, DOI 10.1007/s10803-005-3302-5
EHLERS S, 1993, J CHILD PSYCHOL PSYC, V34, P1327, DOI 10.1111/j.1469-7610.1993.tb02094.x
Ellefsen A, 2007, J AUTISM DEV DISORD, V37, P437, DOI 10.1007/s10803-006-0178-y
Fernell E, 2010, RES DEV DISABIL, V31, P680, DOI 10.1016/j.ridd.2010.01.007
Fombonne E, 2008, BRIT J PSYCHIAT, V193, P159
Gillberg C, 1999, ACTA PSYCHIAT SCAND, V99, P399, DOI 10.1111/j.1600-0447.1999.tb00984.x
Gillberg C., 1991, AUTISM ASPERGER SYND, P122, DOI 10.1017/CBO9780511526770.004
GILLBERG IC, 1989, J CHILD PSYCHOL PSYC, V30, P631, DOI 10.1111/j.1469-7610.1989.tb00275.x
Hallerback M., 2011, DIAGNOSTIC INTERVIEW
Kopp S, 2010, J ATTEN DISORD, V14, P167, DOI 10.1177/1087054709332458
Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
Nygren G, 2009, J AUTISM DEV DISORD, V39, P730, DOI 10.1007/s10803-008-0678-z
Philippe A, 1999, HUM MOL GENET, V8, P805, DOI 10.1093/hmg/8.5.805
Posserud MB, 2009, J AUTISM DEV DISORD, V39, P126, DOI 10.1007/s10803-008-0609-z
Posserud MB, 2006, J CHILD PSYCHOL PSYC, V47, P167, DOI 10.1111/j.1469-7610.2005.01462.x
Ronald A, 2008, EUR CHILD ADOLES PSY, V17, P473, DOI 10.1007/s00787-008-0689-5
Wechsler D., 1992, WECHSLER INTELLIGENC
Wechsler D, 1981, WECHSLER ADULT INTEL
WHO, 1993, ICD 10 CLASS MENT BE
Wing L, 2002, J CHILD PSYCHOL PSYC, V43, P307, DOI 10.1111/1469-7610.00023
NR 22
TC 7
Z9 7
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD SEP
PY 2012
VL 42
IS 9
BP 1959
EP 1966
DI 10.1007/s10803-012-1444-9
PG 8
WC Psychology, Developmental
SC Psychology
GA 992XT
UT WOS:000307815100019
PM 22271195
ER
PT J
AU Tek, S
Landa, RJ
AF Tek, Saime
Landa, Rebecca J.
TI Differences in Autism Symptoms Between Minority and Non-Minority
Toddlers
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism spectrum disorder; Toddlers; Early symptoms; Minority
ID SPECTRUM DISORDERS; CHILDREN; DIAGNOSIS; DISPARITIES; FAMILIES; RACE
AB Little is known about whether early symptom presentation differs in toddlers with ASD from ethnic minority versus non-minority backgrounds. Within a treatment study for toddlers with ASD, we compared 19 minority to 65 Caucasian children and their parents on variables obtained from the Mullen Scales of Early Learning, Autism Diagnostic Observation Schedule, and Communication and Symbolic Behavior Scales Caregiver Questionnaire. The majority of parents were from the upper classes irrespective of ethnic membership. Minority children had lower scores in language, communication, and gross motor than non-minority children. Findings indicate that subtle communication delays may be undetected or presumed unremarkable by parents of minority toddlers, and that more significant delays are needed to prompt the search for intervention services.
C1 [Tek, Saime; Landa, Rebecca J.] Johns Hopkins Univ, Ctr Autism & Related Disorders, Dept Psychiat & Behav Sci, Kennedy Krieger Inst,Sch Med, Baltimore, MD 21211 USA.
RP Landa, RJ (reprint author), Johns Hopkins Univ, Ctr Autism & Related Disorders, Dept Psychiat & Behav Sci, Kennedy Krieger Inst,Sch Med, 3901 Greenspring Ave, Baltimore, MD 21211 USA.
EM landa@kennedykrieger.org
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT, V4
Begeer S, 2009, J AUTISM DEV DISORD, V39, P142, DOI 10.1007/s10803-008-0611-5
Centers for Disease Control and Prevention (CDC), 2006, MENT HLTH US PAR REP
Centers for Disease Control and Prevention (CDC), 2010, AUT SPECTR DIS ASDS
Costello EJ, 2001, AM J PUBLIC HEALTH, V91, P1494, DOI 10.2105/AJPH.91.9.1494
Cuccaro ML, 2007, AM J MED GENET B, V144B, P1022, DOI 10.1002/ajmg.b.30535
Danesco E., 1997, INT J DISABIL DEV ED, V44, P41
Desai PP, 2003, AM J MED GENET B, V116B, P98, DOI 10.1002/ajmg.b.10798
Durkin MS, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0011551
Fombonne E, 2003, J AUTISM DEV DISORD, V33, P365, DOI 10.1023/A:1025054610557
Fountain C., 2010, J EPIDEMIOLOGY COMMU, V65, P503, DOI DOI 10.1136/JECH.2009.104588
Gradin C., 2008, WORKING PAPERS SOC S
Hilton C. L., 2009, J AUTISM DEV DISORD, V40, P633
Hollingshead A. B., 1975, 4 FACTOR INDEX SOCIA
Landa RJ, 2007, ARCH GEN PSYCHIAT, V64, P853, DOI 10.1001/archpsyc.64.7.853
Liptak GS, 2008, J DEV BEHAV PEDIATR, V29, P152, DOI 10.1097/DBP.0b013e318165c7a0
Lord C., 1999, AUTISM DIAGNOSTIC OB
Mandell DS, 2009, AM J PUBLIC HEALTH, V99, P493, DOI 10.2105/AJPH.2007.131243
Mandell DS, 2002, J AM ACAD CHILD PSY, V41, P1447, DOI 10.1097/01.CHI.0000024863.60748.53
Mandell DS, 2005, MENT RETARD DEV D R, V11, P110, DOI 10.1002/mrdd.20061
Mandell DS, 2005, PEDIATRICS, V116, P1480, DOI 10.1542/peds.2005-0185
Mandell DS, 2007, J AUTISM DEV DISORD, V37, P1795, DOI 10.1007/s10803-006-0314-8
Mullen E, 1995, MULLEN SCALES EARLY
Pachter LM, 1997, ARCH PEDIAT ADOL MED, V151, P1144
Post DM, 2001, J NATL MED ASSOC, V93, P6
Rogers-Atkinson D. L., 2003, FOCUS AUTISM OTHER D, V18, P4, DOI 10.1177/108835760301800102
SCHOPLER E, 1979, J AUTISM DEV DISORD, V9, P139, DOI 10.1007/BF01531530
Veling W, 2008, AM J PSYCHIAT, V165, P66
Wetherby A. M., 2002, CSBS DP MANUAL COMMU
Zhang J., 2006, INT J SPECIAL ED, V21, P109
NR 30
TC 8
Z9 8
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD SEP
PY 2012
VL 42
IS 9
BP 1967
EP 1973
DI 10.1007/s10803-012-1445-8
PG 7
WC Psychology, Developmental
SC Psychology
GA 992XT
UT WOS:000307815100020
PM 22271196
ER
PT J
AU Ruble, L
McGrew, JH
Toland, MD
AF Ruble, Lisa
McGrew, John H.
Toland, Michael D.
TI Goal Attainment Scaling as an Outcome Measure in Randomized Controlled
Trials of Psychosocial Interventions in Autism
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Goal attainment scaling; Outcome measurement; Autism; Randomized
controlled trials; Reliability; Psychosocial intervention
ID YOUNG-CHILDREN; REHABILITATION; CONSULTATION; RELIABILITY; DISORDERS
AB Goal attainment scaling (GAS) holds promise as an idiographic approach for measuring outcomes of psychosocial interventions in community settings. GAS has been criticized for untested assumptions of scaling level (i.e., interval or ordinal), inter-individual equivalence and comparability, and reliability of coding across different behavioral observation methods. We tested assumptions of equality between GAS descriptions for outcome measurement in a randomized trial (i.e., measurability, equidistance, level of difficulty, comparability of behavior samples collected from teachers vs. researchers and live vs. videotape). Results suggest GAS descriptions can be evaluated for equivalency, that teacher collected behavior samples are representative, and that varied sources of behavior samples can be reliably coded. GAS is a promising measurement approach. Recommendations are provided to ensure methodological quality.
C1 [Ruble, Lisa; Toland, Michael D.] Univ Kentucky, Dept Educ Sch & Counseling Psychol, Lexington, KY 40506 USA.
[McGrew, John H.] Indiana Univ Purdue Univ, Dept Psychol, Indianapolis, IN 46205 USA.
RP Ruble, L (reprint author), Univ Kentucky, Dept Educ Sch & Counseling Psychol, 237 Dickey Hall, Lexington, KY 40506 USA.
EM lisa.ruble@uky.edu
CR Carrow-Woolfolk E., 1995, OWLS ORAL WRITTEN LA
CYTRYNBAUM S, 1979, EVALUATION QUART, V3, P5, DOI 10.1177/0193841X7900300102
Elliott C. D., 1990, DIFFERENTIAL ABILITY
Jung L., 2011, WEB BASED COAC UNPUB
Kiresuk T, 1994, GOAL ATTAINMENT SCAL
KIRESUK TJ, 1968, COMMUNITY MENT HLT J, V4, P443, DOI 10.1007/BF01530764
Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
MacKay G, 1996, EDUC RES, V38, P161
Malec JF, 1999, NEUROPSYCHOL REHABIL, V9, P253, DOI 10.1080/096020199389365
National Research Council, 2001, ED CHILDR AUT
Ogletree B. T., 2000, FOCUS AUTISM OTHER D, V15, P170, DOI DOI 10.1177/108835760001500308
OTTENBACHER KJ, 1993, AM J OCCUP THER, V47, P349
Quenemoen R., 2003, 53 U MINN NAT CTR ED
Robins DL, 2001, J AUTISM DEV DISORD, V31, P131, DOI 10.1023/A:1010738829569
Ruble L., 2011, WASH DC AM PSYCH ASS
Ruble LA, 2012, COLLABORATIVE MODEL FOR PROMOTING COMPETENCE AND SUCCESS FOR STUDENTS WITH ASD, P1, DOI 10.1007/978-1-4614-2392-4
Ruble L. A., 2002, FOCUS AUTISM OTHER D, V17, P76, DOI DOI 10.1177/10883576020170020201
Ruble LA, 2010, J AUTISM DEV DISORD, V40, P1459, DOI 10.1007/s10803-010-1003-1
Ruble LA, 2010, J EARLY INTERVENTION, V32, P286, DOI 10.1177/1053815110382973
Rutter M., 2003, SOCIAL COMMUNICATION
Schlosser RW, 2004, J COMMUN DISORD, V37, P217, DOI 10.1016/j.jcomdis.2003.09.003
Shefler G, 2001, J CLIN PSYCHOL, V57, P971, DOI 10.1002/jclp.1063
Sheridan S. M., 2006, EARLY EDUC DEV, V17, P593, DOI DOI 10.1207/S15566935EED1704_5
Shuster S. K., 1984, J EARLY INTERVENTION, V8, P26, DOI [10.1177/105381518400800104, DOI 10.1177/105381518400800104]
Sladeczek IE, 2001, J EDUC PSYCHOL CONS, V12, P45, DOI 10.1207/S1532768XJEPC1201_03
Smith A, 1994, GOAL ATTAINMENT SCAL, P1
Sparrow SS, 2005, VINELAND ADAPTIVE BE
Steenbeek D, 2010, ARCH PHYS MED REHAB, V91, P429, DOI 10.1016/j.apmr.2009.10.013
Stolee P, 1999, J AGING HEALTH, V11, P96, DOI 10.1177/089826439901100106
Vacha-Haase T, 2000, EDUC PSYCHOL MEAS, V60, P509, DOI 10.1177/00131640021970682
NR 30
TC 10
Z9 10
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD SEP
PY 2012
VL 42
IS 9
BP 1974
EP 1983
DI 10.1007/s10803-012-1446-7
PG 10
WC Psychology, Developmental
SC Psychology
GA 992XT
UT WOS:000307815100021
PM 22271197
ER
PT J
AU Kimhi, Y
Bauminger-Zviely, N
AF Kimhi, Yael
Bauminger-Zviely, Nirit
TI Collaborative Problem Solving in Young Typical Development and HFASD
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE HFASD; Collaborative problem solving; Peer relations; Preschool
ID AUTISM SPECTRUM DISORDER; HIGH-FUNCTIONING AUTISM; JOINT ATTENTION;
INDIVIDUAL-DIFFERENCES; FRIENDSHIP RELATIONS; EXECUTIVE FUNCTION; SOCIAL
ATTENTION; CHILDREN; MIND; COOPERATION
AB Collaborative problem solving (CPS) requires sharing goals/attention and coordinating actions-all deficient in HFASD. Group differences were examined in CPS (HFASD/typical), with a friend versus with a non-friend. Participants included 28 HFASD and 30 typical children aged 3-6 years and their 58 friends and 58 non-friends. Groups were matched on CA, MA, IQ, and maternal education. The CPS task was placing pairs of blocks to balance scales. HFASD preschoolers solved the problem slower, showed more irrelevant behaviors, shared less, and used fewer coordinative gestures than TYP. But they were more responsive and had more fun with friends versus non-friends. In addition, they solved the problem more efficiently during their second attempt. Implications are discussed, regarding the social deficit of HFASD.
C1 [Kimhi, Yael; Bauminger-Zviely, Nirit] Bar Ilan Univ, Sch Educ, IL-52900 Ramat Gan, Israel.
RP Bauminger-Zviely, N (reprint author), Bar Ilan Univ, Sch Educ, IL-52900 Ramat Gan, Israel.
EM nirit.bauminger@biu.ac.il
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT, V4
Ashley J, 1998, SOC DEV, V7, P143, DOI 10.1111/1467-9507.00059
Baron Cohen S, 1988, J AUTISM DEV DISORD, V18, P378
Bauminger N, 2008, J AUTISM DEV DISORD, V38, P1211, DOI 10.1007/s10803-007-0501-2
Bauminger N, 2011, YOUNG FRIENDSH UNPUB
Bauminger N, 2008, J ABNORM CHILD PSYCH, V36, P135, DOI 10.1007/s10802-007-9156-x
Bishop DVM, 2001, J CHILD PSYCHOL PSYC, V42, P551, DOI 10.1017/S0021963001007247
Brownell CA, 2006, CHILD DEV, V77, P803, DOI 10.1111/j.1467-8624.2006.00904.x
Bukowski WM, 2009, HDB PEER INTERACTION, P217
Calhoun SL, 2005, PSYCHOL SCHOOLS, V42, P333, DOI 10.1002/pits.20067
Carlson SM, 2004, DEV PSYCHOL, V40, P1105, DOI 10.1037/0012-1649.40.6.1105
Carrington S., 2003, FOCUS AUTISM OTHER D, V18, P211, DOI 10.1177/10883576030180040201
Chawarska K, 2007, J CHILD PSYCHOL PSYC, V48, P128, DOI 10.1111/j.1469-7610.2006.01685.x
COOPER CR, 1980, DEV PSYCHOL, V16, P433, DOI 10.1037//0012-1649.16.5.433
Daniel LS, 2010, FOCUS AUTISM DEV DIS, V25, P220, DOI 10.1177/1088357610378290
Dawson G, 2004, DEV PSYCHOL, V40, P271, DOI 10.1037/0012-1649.40.2.271
Dawson G, 1998, J AUTISM DEV DISORD, V28, P479, DOI 10.1023/A:1026043926488
Downs A, 2004, J AUTISM DEV DISORD, V34, P625, DOI 10.1007/s10803-004-5284-0
Dunn J, 2002, CHILD DEV, V73, P621, DOI 10.1111/1467-8624.00427
Dunn J, 1999, SOC DEV, V8, P201, DOI 10.1111/1467-9507.00091
Fawcett LM, 2005, BRIT J EDUC PSYCHOL, V75, P157, DOI 10.1348/000709904X23411
Hartley SL, 2008, J INTELL DISABIL RES, V52, P819, DOI 10.1111/j.1365-2788.2008.01065.x
HARTUP WW, 1988, CHILD DEV, V59, P1590, DOI 10.1111/j.1467-8624.1988.tb03686.x
Hill EL, 2004, J CONSCIOUSNESS STUD, V11, P144
Hill EL, 2004, DEV REV, V24, P189, DOI 10.1016/j.dr.2004.01.001
Hobson JA, 2007, DEV PSYCHOPATHOL, V19, P411, DOI 10.1017/S0954579407070204
Holmes-Lonergan HA, 2003, SEX ROLES, V48, P505, DOI 10.1023/A:1023523228455
Hope G, 2002, CURRICULUM J, V13, P265, DOI 10.1080/0958517022000014655
Howes C., 1996, CO THEY KEEP FRIENDS, P66
Hughes C, 1998, DEV PSYCHOL, V34, P1326, DOI 10.1037/0012-1649.34.6.1326
Hwang B, 2000, J AUTISM DEV DISORD, V30, P331, DOI 10.1023/A:1005579317085
Johnson-Pynn J. S., 2002, CHILD STUDY J, V32, P241
Kanner L, 1943, NERV CHILD, V2, P217
KASARI C, 1990, J AUTISM DEV DISORD, V20, P87, DOI 10.1007/BF02206859
KASARI C, 1993, DEV PSYCHOPATHOL, V5, P403, DOI 10.1017/S0954579400004491
Kumpulainen K, 2003, J EXP EDUC, V71, P333
Kutnick P, 2005, BRIT J EDUC PSYCHOL, V75, P521, DOI 10.1348/000709904X24591
Lemerise EA, 2000, CHILD DEV, V71, P107, DOI 10.1111/1467-8624.00124
Liebal K, 2008, J AUTISM DEV DISORD, V38, P224, DOI 10.1007/s10803-007-0381-5
LORD C, 1989, J AUTISM DEV DISORD, V19, P185, DOI 10.1007/BF02211841
LORD C, 1995, DEV PSYCHOPATHOL, V7, P611
Mayes SD, 2008, J AUTISM DEV DISORD, V38, P428, DOI 10.1007/s10803-007-0410-4
McAlister A, 2006, BRIT J DEV PSYCHOL, V24, P733, DOI 10.1348/026151005X70094
Mullen E, 1995, MULLEN SCALES EARLY
Mundy P, 2007, CURR DIR PSYCHOL SCI, V16, P269, DOI 10.1111/j.1467-8721.2007.00518.x
NEWCOMB AF, 1995, PSYCHOL BULL, V117, P306, DOI 10.1037//0033-2909.117.2.306
OSTERLING J, 1994, J AUTISM DEV DISORD, V24, P247, DOI 10.1007/BF02172225
Pellicano E, 2007, DEV PSYCHOL, V43, P974, DOI 10.1037/0012-1649.43.4.974
Piaget J., 1959, LANGUAGE THOUGHT CHI
Razza RA, 2009, J APPL DEV PSYCHOL, V30, P332, DOI 10.1016/j.appdev.2008.12.020
Rogers J. S., 1991, DEV PSYCHOPATHOL, V3, P137
Sally D, 2006, J ECON PSYCHOL, V27, P73, DOI 10.1016/j.joep.2005.06.015
Sigman M., 1999, MONOGRAPHS SOC RES C, V64
Spek A. A., 2008, J AUTISM DEV DISORD, V33, P782
Steele S, 2003, J AUTISM DEV DISORD, V33, P461, DOI 10.1023/A:1025075115100
Tager-Flusberg H, 2001, DEVELOPMENT OF AUTISM: PERSPECTIVES FROM THEORY AND RESEARCH, P173
Thornton S, 1995, CHILDREN SOLVING PRO
Vygotsky L. S., 1978, MIND SOC
Warneken F, 2006, CHILD DEV, V77, P640, DOI 10.1111/j.1467-8624.2006.00895.x
Wechsler D., 1989, WECHSLER PRESCHOOL P
Wechsler D, 1974, WECHSLER INTELLIGENC
Wechsler D., 2002, WECHSLER PRESCHOOL P, V3rd
Zajac RJ, 1997, ELEM SCHOOL J, V98, P3, DOI 10.1086/461881
NR 63
TC 3
Z9 3
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD SEP
PY 2012
VL 42
IS 9
BP 1984
EP 1997
DI 10.1007/s10803-012-1447-6
PG 14
WC Psychology, Developmental
SC Psychology
GA 992XT
UT WOS:000307815100022
PM 22274778
ER
PT J
AU Bolte, S
AF Bolte, Sven
TI Brief Report: The Social Responsiveness Scale for Adults (SRS-A):
Initial Results in a German Cohort
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Questionnaire; Broader phenotype; Psychometrics; Screening; Assessment
ID AUTISTIC TRAITS; VALIDATION
AB The Social Responsiveness Scale (SRS) is a tool for quantitative autism assessment in children and adolescents. The SRS-A addresses social responsiveness in adulthood. Reliability and validity using the German adaptation of the SRS-A was examined in 20 adults with Autism Spectrum Disorder (ASD), 62 with other mental disorders (CLIN) and 163 typically developing (TD) participants. Cronbach's alpha ranged from .71 (TD) to .89 (ASD). A SRS-A total score of 67 had a sensitivity of .85, and a specificity of .83 for ASD versus CLIN/TD. Correlations with established autism scales (ADOS, AQ, SCQ) were moderate to high (r = .25-.83). Results provide adequate preliminary support for the application of the SRS-A.
C1 Karolinska Inst, Dept Womens & Childrens Hlth, Ctr Neurodev Disorders, Karolinska Inst KIND,Astrid Lindgren Childrens Ho, S-17176 Stockholm, Sweden.
RP Bolte, S (reprint author), Karolinska Inst, Dept Womens & Childrens Hlth, Ctr Neurodev Disorders, Karolinska Inst KIND,Astrid Lindgren Childrens Ho, Q2 07, S-17176 Stockholm, Sweden.
EM sven.bolte@ki.se
CR Bolte S, 2008, AUTISM RES, V1, P354, DOI 10.1002/aur.49
Bolte S, 2011, J AUTISM DEV DISORD, V41, P66, DOI 10.1007/s10803-010-1024-9
Constantino JN, 2005, BIOL PSYCHIAT, V57, P655, DOI 10.1016/j.biopsych.2004.12.014
Constantino JN, 2003, J AUTISM DEV DISORD, V33, P427, DOI 10.1023/A:1025014929212
Virkud YV, 2009, AM J MED GENET B, V150B, P328, DOI 10.1002/ajmg.b.30810
NR 5
TC 7
Z9 7
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD SEP
PY 2012
VL 42
IS 9
BP 1998
EP 1999
DI 10.1007/s10803-011-1424-5
PG 2
WC Psychology, Developmental
SC Psychology
GA 992XT
UT WOS:000307815100023
PM 22183423
ER
PT J
AU Lee, BK
Gardner, RM
Dal, H
Svensson, A
Galanti, MR
Rai, D
Dalman, C
Magnusson, C
AF Lee, Brian K.
Gardner, Renee M.
Dal, Henrik
Svensson, Anna
Galanti, Maria Rosaria
Rai, Dheeraj
Dalman, Christina
Magnusson, Cecilia
TI Brief Report: Maternal Smoking During Pregnancy and Autism Spectrum
Disorders
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism; Population register; Smoking; Sweden; Tobacco
ID RISK-FACTORS; CHILDREN; EPIDEMIOLOGY; EXPOSURE; PREVALENCE; OUTCOMES
AB Prenatal exposure to tobacco smoke is suggested as a potential risk factor for autism spectrum disorders (ASD). Previous epidemiological studies of this topic have yielded mixed findings. We performed a case-control study of 3,958 ASD cases and 38,983 controls nested in a large register-based cohort in Sweden. ASD case status was measured using a multisource case ascertainment system. In adjusted results, we found that maternal smoking during pregnancy is not associated with increased risk of ASD regardless of presence or absence of comorbid intellectual disability. Apparent associations were attributable to confounding by sociodemographic characteristics of parents such as education, income, and occupation.
C1 [Lee, Brian K.] Drexel Univ, Dept Epidemiol & Biostat, Sch Publ Hlth, Philadelphia, PA 19104 USA.
[Gardner, Renee M.] Karolinska Inst, Inst Environm Med, Div Met & Hlth, S-10401 Stockholm, Sweden.
[Dal, Henrik; Svensson, Anna; Dalman, Christina; Magnusson, Cecilia] Karolinska Inst, Div Publ Hlth Epidemiol, Dept Publ Hlth Sci, Stockholm, Sweden.
[Galanti, Maria Rosaria] Karolinska Univ Hosp, Dept Med, Clin Epidemiol Unit, Stockholm, Sweden.
[Rai, Dheeraj] Univ Bristol, Acad Unit Psychiat, Sch Social & Community Med, Bristol, Avon, England.
[Rai, Dheeraj] Avon & Wiltshire Partnership NHS Mental Hlth Trus, Bristol, Avon, England.
RP Lee, BK (reprint author), Drexel Univ, Dept Epidemiol & Biostat, Sch Publ Hlth, Philadelphia, PA 19104 USA.
EM bklee@drexel.edu
RI Gardner, Renee/B-8193-2013
OI Gardner, Renee/0000-0002-7011-798X
CR Axen M., 2010, ADHD LINDRIG UTVECKL
Burstyn I, 2010, CHRONIC DIS CAN, V30, P125
CNATTINGIUS S, 1990, SCAND J SOC MED, V18, P143
Cnattingius S, 2004, NICOTINE TOB RES, V6, pS125, DOI 10.1080/14622200410001669187
Cornelius MD, 2011, NEUROTOXICOL TERATOL, V33, P137, DOI 10.1016/j.ntt.2010.08.006
Eskenazi B, 1999, ENVIRON HEALTH PERSP, V107, P991
Fountain C., 2010, J EPIDEMIOLOGY COMMU, V65, P503, DOI DOI 10.1136/JECH.2009.104588
George L, 2006, ACTA OBSTET GYN SCAN, V85, P1331, DOI 10.1080/00016340600935433
Gillberg C, 2006, J AUTISM DEV DISORD, V36, P429, DOI 10.1007/s10803-006-0081-6
Hultman C, 2010, MOL PSYCHIATR, V16, P1203
Hultman CM, 2002, EPIDEMIOLOGY, V13, P417, DOI 10.1097/01.EDE.0000016968.14007.E6
Julvez J, 2007, INT J EPIDEMIOL, V36, P825, DOI 10.1093/ije/dym107
Kalkbrenner A. E., 2010, INT SOC AUTISM RES
Larsson HJ, 2005, AM J EPIDEMIOL, V161, P916, DOI 10.1093/aje/kwi123
Lichtenstein P, 2010, AM J PSYCHIAT, V167, P1357, DOI 10.1176/appi.ajp.2010.10020223
Lu Y, 2001, HEALTH PROMOT INT, V16, P355, DOI 10.1093/heapro/16.4.355
Ludvigsson JF, 2009, EUR J EPIDEMIOL, V24, P659, DOI 10.1007/s10654-009-9350-y
Milberger S, 1996, AM J PSYCHIAT, V153, P1138
National Board of Health and Welfare Center of Epidemiology, 2003, SWED MED BIRTH REG S
Newschaffer CJ, 2007, ANNU REV PUBL HEALTH, V28, P235, DOI 10.1146/annurev.publhealth.28.021406.144007
Shea AK, 2008, NICOTINE TOB RES, V10, P267, DOI 10.1080/14622200701825908
Szatmari P, 2007, INT REV PSYCHIATR, V19, P483, DOI 10.1080/09540260701563619
NR 22
TC 11
Z9 11
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD SEP
PY 2012
VL 42
IS 9
BP 2000
EP 2005
DI 10.1007/s10803-011-1425-4
PG 6
WC Psychology, Developmental
SC Psychology
GA 992XT
UT WOS:000307815100024
PM 22173844
ER
PT J
AU Barber, AB
Wetherby, AM
Chambers, NW
AF Barber, Angela B.
Wetherby, Amy M.
Chambers, Nola W.
TI Brief Report: Repetitive Behaviors in Young Children with Autism
Spectrum Disorder and Developmentally Similar Peers: A Follow Up to Watt
et al. (2008)
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Repetitive behavior; Typical development; Early identification;
Measurement
ID NORMAL HUMAN INFANTS; 2ND YEAR; LIFE
AB The present study extended the findings of Watt et al. (J Autism Dev Disord 38:1518-1533, 2008) by investigating repetitive and stereotyped behaviors (RSB) demonstrated by children (n = 50) and typical development (TD; n = 50) matched on developmental age, gender, and parents' education level. RSB were coded from videotaped Communication and Symbolic Behavior Scales Behavior Samples (Wetherby and Prizant 2002) using the Noldus Pro ObserverA (c) video software. Children with ASD demonstrated significantly higher frequencies of RSB with body objects excluding categories involving banging or tapping objects or surfaces. Behaviors demonstrated by both groups indicated overlapping RSB profiles at this age. These findings highlight the significance of RSB in the early identification and support the need for future research to further determine ASD-specific RSB.
C1 [Barber, Angela B.] Univ Alabama, Dept Communicat Disorders, Tuscaloosa, AL 35487 USA.
[Wetherby, Amy M.] Univ Witwatersrand, Johannesburg, South Africa.
[Chambers, Nola W.] Florida State Univ, WORDS Project 1, Tallahassee, FL 32306 USA.
RP Barber, AB (reprint author), Univ Alabama, Dept Communicat Disorders, 700 Univ Blvd E,POB 870242, Tuscaloosa, AL 35487 USA.
EM abarber@bama.ua.edu
CR Bishop SL, 2006, CHILD NEUROPSYCHOL, V12, P247, DOI 10.1080/09297040600630288
Bruckner CT, 2006, AM J MENT RETARD, V111, P433, DOI 10.1352/0895-8017(2006)111[433:IKIORB]2.0.CO;2
COHEN J, 1960, EDUC PSYCHOL MEAS, V20, P37, DOI 10.1177/001316446002000104
Evans DW, 1997, CHILD DEV, V68, P58, DOI 10.2307/1131925
Gabriels RL, 2005, RES DEV DISABIL, V26, P169, DOI 10.1016/j.ridd.2004.05.003
Kim SH, 2010, AUTISM RES, V3, P162, DOI 10.1002/aur.142
Kravitz H., 1971, CHILD DEV, V42, P388
Leekam S, 2007, J CHILD PSYCHOL PSYC, V48, P1131, DOI 10.1111/j.1469-7610.2007.01778.x
Morgan L, 2008, J CHILD PSYCHOL PSYC, V49, P826, DOI 10.1111/j.1469-7610.2008.01904.x
Osterling JA, 2002, DEV PSYCHOPATHOL, V14, P239
Richler J, 2007, J AUTISM DEV DISORD, V37, P73, DOI 10.1007/s10803-006-0332-6
Richler J., 2006, J AUTISM DEV DISORD, V37, P73
Richler J, 2010, DEV PSYCHOPATHOL, V22, P55, DOI 10.1017/S0954579409990265
THELEN E, 1981, ANIM BEHAV, V29, P3, DOI 10.1016/S0003-3472(81)80146-7
THELEN E, 1979, ANIM BEHAV, V27, P699, DOI 10.1016/0003-3472(79)90006-X
Turner M, 1999, J CHILD PSYCHOL PSYC, V40, P839, DOI 10.1017/S0021963099004278
Watson LR, 2007, J AUTISM DEV DISORD, V37, P49, DOI 10.1007/s10803-006-0334-4
Watt N, 2008, J AUTISM DEV DISORD, V38, P1518, DOI 10.1007/s10803-007-0532-8
Werner E, 2005, ARCH GEN PSYCHIAT, V62, P889, DOI 10.1001/archpsyc.62.8.889
Werner E, 2005, J AUTISM DEV DISORD, V35, P337, DOI 10.1007/s10803-005-3301-6
Wetherby A. M., 2007, REPETITIVE STE UNPUB
Wetherby AM, 2007, J AUTISM DEV DISORD, V37, P960, DOI 10.1007/s10803-006-0237-4
Wetherby AM, 2002, COMMUNICATION SYMBOL
Wetherby AM, 2004, J AUTISM DEV DISORD, V34, P473, DOI 10.1007/s10803-004-2544-y
Zohar AH, 2001, J ABNORM CHILD PSYCH, V29, P121, DOI 10.1023/A:1005231912747
NR 25
TC 5
Z9 6
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD SEP
PY 2012
VL 42
IS 9
BP 2006
EP 2012
DI 10.1007/s10803-011-1434-3
PG 7
WC Psychology, Developmental
SC Psychology
GA 992XT
UT WOS:000307815100025
PM 22222776
ER
PT J
AU Yerys, BE
Wolff, BC
Moody, E
Pennington, BF
Hepburn, SL
AF Yerys, Benjamin E.
Wolff, Brian C.
Moody, Eric
Pennington, Bruce F.
Hepburn, Susan L.
TI Brief Report: Impaired Flexible Item Selection Task (FIST) in School-Age
Children with Autism Spectrum Disorders
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Cognitive flexibility; Autism spectrum disorders; Set-shifting;
Executive function; Cognitive control
ID ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; HIGH-FUNCTIONING CHILDREN;
LATENT VARIABLE ANALYSIS; EXECUTIVE FUNCTION; REPETITIVE BEHAVIORS;
COGNITIVE CONTROL; DEFICITS; PROFILES; PERFORMANCE; INTERESTS
AB Cognitive flexibility has been measured with inductive reasoning or explicit rule tasks in individuals with autism spectrum disorders (ASD). The Flexible Item Selection Task (FIST) differs from previous cognitive flexibility tasks in ASD research by giving children an abstract, ambiguous rule to switch. The ASD group (N = 22; Mean age = 8.28 years, SD = 1.52) achieved a lower shift percentage than the typically developing verbal mental-age control group (N = 22; Mean age = 6.26 years, SD = 0.82). There was a significant positive correlation between verbal mental age and shift percentage for children with ASD. Group differences on the FIST converge and extend prior evidence documenting an impaired ability to adapt rapidly to changes in task demands for individuals with ASD.
C1 [Yerys, Benjamin E.] Childrens Hosp Philadelphia, Ctr Autism Res, Philadelphia, PA 19104 USA.
[Wolff, Brian C.; Moody, Eric; Hepburn, Susan L.] Univ Colorado, Hlth Sci Ctr, Dept Psychiat, JFK Partners, Denver, CO 80262 USA.
[Pennington, Bruce F.] Univ Denver, Dept Psychol, Denver, CO 80208 USA.
RP Yerys, BE (reprint author), Childrens Hosp Philadelphia, Ctr Autism Res, 3535 Market St,Suite 860, Philadelphia, PA 19104 USA.
EM yerysb@email.chop.edu
CR Biro S, 2001, DEV PSYCHOPATHOL, V13, P97, DOI 10.1017/S0954579401001079
Boyd BA, 2009, RES AUTISM SPECT DIS, V3, P959, DOI 10.1016/j.rasd.2009.05.003
Burgess PW, 2006, J INT NEUROPSYCH SOC, V12, P194, DOI 10.1017/S135561770606310
Cambridge-Cognition, 1996, CANTAB
Dennis M, 2009, J INT NEUROPSYCH SOC, V15, P331, DOI 10.1017/S1355617709090481
Dunn L. M., 1997, EXAMINERS MANUAL PPV
Feldman MJ, 1951, PSYCHIAT QUART, V25, P55
Geurts HM, 2009, TRENDS COGN SCI, V13, P74, DOI 10.1016/j.tics.2008.11.006
Geurts HM, 2004, J CHILD PSYCHOL PSYC, V45, P836, DOI 10.1111/j.1469-7610.2004.00276.x
Gioia GA, 2002, CHILD NEUROPSYCHOL, V8, P121
Goldberg MC, 2005, J AUTISM DEV DISORD, V35, P279, DOI 10.1007/s10803-005-3291-4
Happe F, 2006, BRAIN COGNITION, V61, P25, DOI 10.1016/j.bandc.2006.03.004
Heaton R., 1993, WCST MANUAL REVISED
Hill EL, 2004, DEV REV, V24, P189, DOI 10.1016/j.dr.2004.01.001
Huizinga M, 2006, NEUROPSYCHOLOGIA, V44, P2017, DOI 10.1016/j.neuropsychologia.2006.01.010
Jacques S., 2005, ROLES LABELING ABSTR
Jacques S, 2005, DEVELOPMENT OF SOCIAL COGNITION AND COMMUNICATION, P53
Jacques S, 2001, DEV NEUROPSYCHOL, V20, P573, DOI 10.1207/875656401753549807
Jacques S., 2002, INT M AUT RES ORL FL
Joseph RM, 2002, J CHILD PSYCHOL PSYC, V43, P807, DOI 10.1111/1469-7610.00092
Kenworthy L, 2008, NEUROPSYCHOL REV, V18, P320, DOI 10.1007/s11065-008-9077-7
Kenworthy L, 2009, CHILD NEUROPSYCHOL, V15, P425, DOI 10.1080/09297040802646983
Lam KSL, 2007, J AUTISM DEV DISORD, V37, P855, DOI 10.1007/s10803-006-0213-z
Liss M, 2001, J CHILD PSYCHOL PSYC, V42, P261, DOI 10.1017/S0021963001006679
Lopez BR, 2005, J AUTISM DEV DISORD, V35, P445, DOI 10.1007/s10803-005-5035-x
Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
Maes JHR, 2011, J CLIN EXP NEUROPSYC, V33, P210, DOI 10.1080/13803395.2010.501327
Miyake A, 2000, COGNITIVE PSYCHOL, V41, P49, DOI 10.1006/cogp.1999.0734
OZONOFF S, 1995, NEUROPSYCHOLOGY, V9, P491, DOI 10.1037//0894-4105.9.4.491
Ozonoff S, 2004, J AUTISM DEV DISORD, V34, P139, DOI 10.1023/B:JADD.0000022605.81989.cc
Pascualvaca DM, 1998, J AUTISM DEV DISORD, V28, P467, DOI 10.1023/A:1026091809650
Pennington BF, 1996, J CHILD PSYCHOL PSYC, V37, P51, DOI 10.1111/j.1469-7610.1996.tb01380.x
Poljac E, 2010, Q J EXP PSYCHOL, V63, P401, DOI 10.1080/17470210902990803
Richler J, 2010, DEV PSYCHOPATHOL, V22, P55, DOI 10.1017/S0954579409990265
Rogers SJ, 2000, J AUTISM DEV DISORD, V30, P399, DOI 10.1023/A:1005543321840
Rutter M., 2003, SOCIAL COMMUNICATION
Schmitz N, 2006, BIOL PSYCHIAT, V59, P7, DOI 10.1016/j.biopsych.2005.06.007
Sergeant JA, 2002, BEHAV BRAIN RES, V130, P3, DOI 10.1016/S0166-4328(01)00430-2
Shafritz KM, 2008, BIOL PSYCHIAT, V63, P974, DOI 10.1016/j.biopsych.2007.06.028
Smith CJ, 2009, J CHILD PSYCHOL PSYC, V50, P982, DOI 10.1111/j.1469-7610.2009.02060.x
Solomon M, 2009, NEUROPSYCHOLOGIA, V47, P2515, DOI 10.1016/j.neuropsychologia.2009.04.019
Solomon M, 2008, INT J DEV NEUROSCI, V26, P239, DOI 10.1016/j.ijdevneu.2007.11.001
South M, 2007, AUTISM, V11, P437, DOI 10.1177/1362361307079606
Wechsler D., 2002, WECHSLER PRESCHOOL P, V3rd
Wechsler D, 1999, WECHSLER ABBREVIATED
WELSH MC, 1988, DEV NEUROPSYCHOL, V4, P199
Yerys BE, 2009, AUTISM, V13, P523, DOI 10.1177/1362361309335716
Zelazo PD, 2006, NAT PROTOC, V1, P297, DOI 10.1038/nprot.2006.46
NR 48
TC 4
Z9 4
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD SEP
PY 2012
VL 42
IS 9
BP 2013
EP 2020
DI 10.1007/s10803-012-1443-x
PG 8
WC Psychology, Developmental
SC Psychology
GA 992XT
UT WOS:000307815100026
PM 22271194
ER
PT J
AU Aitken, K
AF Aitken, Kenneth
TI Autism Spectrum Conditions: FAQs on Autism, Asperger Syndrome, and
Atypical Autism Answered by International Experts
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Book Review
C1 [Aitken, Kenneth] Hillside Residential Facil, Aberdour KY30RH, Scotland.
[Aitken, Kenneth] Templeton Business Ctr, GGHB, LD CAMHS, Glasgow, Lanark, Scotland.
RP Aitken, K (reprint author), 198 Whitehouse Rd, Edinburgh EH4 6BX, Midlothian, Scotland.
EM drken.aitken@btinternet.com
CR Bolte S, 2011, AUTISM SPECTRUM COND
Clare I., 2009, NEUROPSYCHOLOGY PRAC, P109
NR 2
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD SEP
PY 2012
VL 42
IS 9
BP 2023
EP 2024
DI 10.1007/s10803-011-1395-6
PG 2
WC Psychology, Developmental
SC Psychology
GA 992XT
UT WOS:000307815100028
ER
PT J
AU VanBergeijk, E
AF VanBergeijk, Ernst
TI Crafting Connections: Contemporary Applied Behavior Analysis for
Enriching the Social Lives of Persons with Autism Spectrum Disorder
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Book Review
C1 [VanBergeijk, Ernst] New York Inst Technol, Vocat Independence Program, Cent Islip, NY 11722 USA.
RP VanBergeijk, E (reprint author), New York Inst Technol, Vocat Independence Program, 300 Carleton Ave,Room 112,Independence Hall, Cent Islip, NY 11722 USA.
EM evanberg@nyit.edu
CR Taubman M., 2011, CRAFTING CONNECTIONS
NR 1
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD SEP
PY 2012
VL 42
IS 9
BP 2025
EP 2025
DI 10.1007/s10803-011-1396-5
PG 1
WC Psychology, Developmental
SC Psychology
GA 992XT
UT WOS:000307815100029
ER
PT J
AU Tanpowpong, P
Broder-Fingert, S
Katz, AJ
Camargo, CA
AF Tanpowpong, Pornthep
Broder-Fingert, Sarabeth
Katz, Aubrey J.
Camargo, Carlos A., Jr.
TI Predictors of Gluten Avoidance and Implementation of a Gluten-Free Diet
in Children and Adolescents without Confirmed Celiac Disease
SO JOURNAL OF PEDIATRICS
LA English
DT Article
ID IRRITABLE-BOWEL-SYNDROME; QUALITY-OF-LIFE; AT-RISK GROUPS;
LACTOSE-INTOLERANCE; UNITED-STATES; PREVALENCE; DIAGNOSIS; AUTISM;
BLIND; INDIVIDUALS
AB Objectives To determine independent predictors of gluten avoidance and of a physician's decision to initiate a gluten-free diet (GFD) in children and adolescents without confirmed celiac disease.
Study design We performed a structured medical record review of 579 patients aged 1-19 years presenting for evaluation of celiac disease between January 2000 and December 2010 at a large Boston teaching hospital. We collected data including demographic information, medical history, serology, small intestinal biopsy, history of gluten avoidance, and the postworkup recommendation of implementation of a GFD. Predictors of gluten-related issues were identified by multivariate logistic regression.
Results Among 579 children without a previous diagnosis of celiac disease (mean age, 8.7 years), 43 (7.4%) had ever avoided gluten. Independent predictors of gluten avoidance were irritability or poor temper (OR, 3.2), diarrhea (OR, 2.5), weight issues (OR, 0.4), pervasive developmental disorder (OR, 5.3), and family history of celiac disease (OR, 2.2). Among 143 children without confirmed celiac disease who underwent diagnostic evaluation, several predictive factors were associated with a physician-recommended/parent-initiated GFD: irritability (OR, 6.4), diarrhea (OR, 3.4), pervasive developmental disorder (OR, 7.9), and positive serology before the referral (OR, 4.3).
Conclusion Gluten avoidance among children and adolescents without a previous diagnosis of celiac disease is relatively common. The identified predictors suggest that gluten avoidance is associated with nonspecific behavioral and gastrointestinal complaints and perhaps with the perceived dietary responses in another family member thought to have celiac disease. (J Pediatr 2012;161:471-5).
C1 [Camargo, Carlos A., Jr.] Harvard Univ, Massachusetts Gen Hosp, Dept Emergency Med, Sch Med, Boston, MA 02114 USA.
[Tanpowpong, Pornthep; Broder-Fingert, Sarabeth; Katz, Aubrey J.] Harvard Univ, Massachusetts Gen Hosp, Div Pediat Gastroenterol & Nutr, Sch Med, Boston, MA 02114 USA.
RP Camargo, CA (reprint author), Harvard Univ, Massachusetts Gen Hosp, Dept Emergency Med, Sch Med, 326 Cambridge St,Suite 410, Boston, MA 02114 USA.
EM ccamargo@partners.org
CR Biesiekierski JR, 2011, AM J GASTROENTEROL, V106, P508, DOI 10.1038/ajg.2010.487
Buie T, 2010, PEDIATRICS, V125, pS1, DOI 10.1542/peds.2009-1878C
Cinquetti M, 1999, Pediatr Med Chir, V21, P279
Elder JH, 2006, J AUTISM DEV DISORD, V36, P413, DOI 10.1007/s10803-006-0079-0
Fasano A, 2003, ARCH INTERN MED, V163, P286, DOI 10.1001/archinte.163.3.286
Ford AC, 2009, ARCH INTERN MED, V169, P651, DOI 10.1001/archinternmed.2009.22
Guandalini Stefano, 2011, Curr Gastroenterol Rep, V13, P426, DOI 10.1007/s11894-011-0215-7
Hallert C, 1998, SCAND J GASTROENTERO, V33, P933, DOI 10.1080/003655298750026949
Heyman MB, 2006, PEDIATRICS, V118, P1279, DOI 10.1542/peds.2006-1721
Hill I, 2000, J PEDIATR-US, V136, P86, DOI 10.1016/S0022-3476(00)90055-6
Hill ID, 2005, J PEDIATR GASTR NUTR, V40, P1, DOI 10.1097/00005176-200501000-00001
Kupper C, 2005, GASTROENTEROLOGY, V128, pS121, DOI 10.1053/j.gastro.2005.02.024
Kurppa K, 2010, J PEDIATR-US, V157, P373, DOI 10.1016/j.jpeds.2010.02.070
Lionetti E, 2010, DEV MED CHILD NEUROL, V52, P700, DOI 10.1111/j.1469-8749.2010.03647.x
Long KH, 2010, ALIMENT PHARM THER, V32, P261, DOI 10.1111/j.1365-2036.2010.04327.x
Ludvigsson JF, 2011, J INTERN MED, V269, P560, DOI 10.1111/j.1365-2796.2011.02379.x
McGowan KE, 2009, PEDIATRICS, V124, P1572, DOI 10.1542/peds.2008-2373
Mustalahti K, 2010, ANN MED, V42, P587, DOI 10.3109/07853890.2010.505931
Oberhuber G, 1999, EUR J GASTROEN HEPAT, V11, P1185, DOI 10.1097/00042737-199910000-00019
Ojetti V, 2005, DIGESTION, V71, P106, DOI 10.1159/000084526
Pavone L, 1997, BIOL PSYCHIAT, V42, P72, DOI 10.1016/S0006-3223(97)00267-9
Sapone A, 2011, BMC MED, V9, DOI 10.1186/1741-7015-9-23
Tanpowpong P, 2012, ARCH DIS CHILD, V97, P12, DOI 10.1136/archdischild-2011-300248
Tosco A, 2011, CLIN GASTROENTEROL H, V9, P320, DOI 10.1016/j.cgh.2010.09.006
Troncone R, 2008, CURR OPIN CLIN NUTR, V11, P329, DOI 10.1097/MCO.0b013e3282f795f8
Ukkola A, 2011, CLIN GASTROENTEROL H, V9, P118, DOI 10.1016/j.cgh.2010.10.011
Vesa TH, 1998, AM J CLIN NUTR, V67, P710
Wagner G, 2008, J PEDIATR GASTR NUTR, V47, P555, DOI 10.1097/MPG.0b013e31817fcb56
Whiteley P, 2010, NUTR NEUROSCI, V13, P87, DOI 10.1179/147683010X12611460763922
NR 29
TC 6
Z9 6
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0022-3476
J9 J PEDIATR-US
JI J. Pediatr.
PD SEP
PY 2012
VL 161
IS 3
BP 471
EP 475
DI 10.1016/j.jpeds.2012.02.049
PG 5
WC Pediatrics
SC Pediatrics
GA 997CL
UT WOS:000308141700023
PM 22484356
ER
PT J
AU Valicenti-McDermott, M
Hottinger, K
Seijo, R
Shulman, L
AF Valicenti-McDermott, Maria
Hottinger, Kathryn
Seijo, Rosa
Shulman, Lisa
TI Age at Diagnosis of Autism Spectrum Disorders
SO JOURNAL OF PEDIATRICS
LA English
DT Article
ID CHILDREN; SERVICES
AB Early identification of autism has become a national priority but, despite efforts, there are children who are being identified at a later age. In this study, children of Hispanic and African American origin, foreign-born children, and children born to foreign mothers were more likely to be diagnosed later. (J Pediatr 2012;161:554-6)
C1 Albert Einstein Coll Med, Dept Pediat, Bronx, NY 10467 USA.
Albert Einstein Coll Med, Childrens Evaluat & Rehabil Ctr, Rose F Kennedy Ctr Excellence Dev Disabil, Bronx, NY 10467 USA.
RP Valicenti-McDermott, M (reprint author), Childrens Evaluat & Rehabil Ctr AECOM, 1410 Pelham Pkwy S, Bronx, NY 10461 USA.
EM rvalicenti@hotmail.com
CR [Anonymous], 2000, DIAGNOSTIC STAT MANU
Bayley N., 2006, MANUAL BAYLEY SCALES, V3rd
CDC (Cent. Dis. Control Prev.), 2007, MMWR SURVEILL SUMM, V56, P12
Dawson G, 2010, PEDIATRICS, V125, pE17, DOI 10.1542/peds.2009-0958
Hess KL, 2008, J AUTISM DEV DISORD, V38, P961, DOI 10.1007/s10803-007-0470-5
Johnson CP, 2007, PEDIATRICS, V120, P1183, DOI 10.1542/peds.2007-2361
Liptak GS, 2008, J DEV BEHAV PEDIATR, V29, P152, DOI 10.1097/DBP.0b013e318165c7a0
Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
Magnuson KA, 2005, FUTURE CHILD, V15, P169, DOI 10.1353/foc.2005.0005
Mandell DS, 2009, AM J PUBLIC HEALTH, V99, P493, DOI 10.2105/AJPH.2007.131243
Mandell DS, 2002, J AM ACAD CHILD PSY, V41, P1447, DOI 10.1097/01.CHI.0000024863.60748.53
Mandell DS, 2005, PEDIATRICS, V116, P1480, DOI 10.1542/peds.2005-0185
McGee J. P., 2001, ED CHILDREN AUTISM
Roid G. H., 2003, STANFORD BINET INTEL
Schopler E., 1988, CHILDHOOD AUTISM RAT
Shulman LH, 1997, J PEDIATR-US, V130, P541, DOI 10.1016/S0022-3476(97)70236-1
Sparrow SS, 2005, VINELAND ADAPTIVE BE
Spence Sarah J., 2006, UNDERSTANDING AUTISM, P1
NR 18
TC 12
Z9 12
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0022-3476
J9 J PEDIATR-US
JI J. Pediatr.
PD SEP
PY 2012
VL 161
IS 3
BP 554
EP 556
DI 10.1016/j.jpeds.2012.05.012
PG 3
WC Pediatrics
SC Pediatrics
GA 997CL
UT WOS:000308141700039
PM 22683037
ER
PT J
AU van Dongen, J
Slagboom, PE
Draisma, HHM
Martin, NG
Boomsma, DI
AF van Dongen, Jenny
Slagboom, P. Eline
Draisma, Harmen H. M.
Martin, Nicholas G.
Boomsma, Dorret I.
TI The continuing value of twin studies in the omics era
SO NATURE REVIEWS GENETICS
LA English
DT Review
ID DISCORDANT MONOZYGOTIC TWINS; AUTISM SPECTRUM DISORDERS; LYMPHOBLASTOID
CELL-LINES; GENOME-WIDE ASSOCIATION; POPULATION-BASED TWIN; GENETIC
INFLUENCES; DNA METHYLATION; BIPOLAR DISORDER; BIRTH-WEIGHT; EPIGENETIC
DIFFERENCES
AB The classical twin study has been a powerful heuristic in biomedical, psychiatric and behavioural research for decades. Twin registries worldwide have collected biological material and longitudinal phenotypic data on tens of thousands of twins, providing a valuable resource for studying complex phenotypes and their underlying biology. In this Review, we consider the continuing value of twin studies in the current era of molecular genetic studies. We conclude that classical twin methods combined with novel technologies represent a powerful approach towards identifying and understanding the molecular pathways that underlie complex traits.
C1 [van Dongen, Jenny; Draisma, Harmen H. M.; Boomsma, Dorret I.] Vrije Univ Amsterdam, NL-1081 BT Amsterdam, Netherlands.
[Martin, Nicholas G.] Queensland Inst Med Res, Genet Epidemiol Unit, Brisbane, Qld 4006, Australia.
[Slagboom, P. Eline] Leiden Univ, Med Ctr, Netherlands Consortium Healthy Ageing, NL-2333 ZC Leiden, Netherlands.
RP Boomsma, DI (reprint author), Vrije Univ Amsterdam, Van der Boechorststr 1, NL-1081 BT Amsterdam, Netherlands.
EM di.boomsma@vu.nl
FU European Research Council [ERC 230374]; Institute for Health and Care
Research (EMGO+)
FX This work was supported by the European Research Council (ERC 230374)
and the Institute for Health and Care Research (EMGO+).
CR Agrawal A, 2008, ADDICTION, V103, P1069, DOI 10.1111/j.1360-0443.2008.02213.x
Alkan C, 2011, NAT REV GENET, V12, P363, DOI 10.1038/nrg2958
Amaral PP, 2008, SCIENCE, V319, P1787, DOI 10.1126/science.1155472
Bakaysa SL, 2007, AGING CELL, V6, P769, DOI 10.1111/j.1474-9726.2007.00340.x
Baranzini SE, 2010, NATURE, V464, P1351, DOI 10.1038/nature08990
Bell JT, 2011, TRENDS GENET, V27, P116, DOI 10.1016/j.tig.2010.12.005
BERG K, 1988, CLIN GENET, V33, P102
Beyan H, 2010, DIABETES, V59, P1751, DOI 10.2337/db09-1433
Boomsma D I, 1998, Twin Res, V1, P34, DOI 10.1375/136905298320566465
Brant AM, 2009, BEHAV GENET, V39, P393, DOI 10.1007/s10519-009-9268-x
Busjahn A, 2006, TWIN RES HUM GENET, V9, P705, DOI 10.1375/183242706779462714
Caramori ML, 2012, DIABETES, V61, P739, DOI 10.2337/db11-0617
Cardno AG, 1999, ARCH GEN PSYCHIAT, V56, P162, DOI 10.1001/archpsyc.56.2.162
Caspi A, 2007, P NATL ACAD SCI USA, V104, P18860, DOI 10.1073/pnas.0704292104
Caspi A, 2006, NAT REV NEUROSCI, V7, P583, DOI 10.1038/nrn1925
Clausson B, 2000, BRIT J OBSTET GYNAEC, V107, P375, DOI 10.1111/j.1471-0528.2000.tb13234.x
Coolen MW, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0025590
de Geus EJC, 2007, BIOL PSYCHIAT, V61, P1062, DOI 10.1016/j.biopsych.2006.07.026
de Geus EJC, 2002, BIOL PSYCHOL, V61, P1, DOI 10.1016/S0301-0511(02)00049-2
De Moor MHM, 2008, ARCH GEN PSYCHIAT, V65, P897, DOI 10.1001/archpsyc.65.8.897
Dempster EL, 2011, HUM MOL GENET, V20, P4786, DOI 10.1093/hmg/ddr416
EAVES LJ, 1977, J ROY STAT SOC A STA, V140, P324, DOI 10.2307/2344924
Ehli EA, 2012, EUR J HUM GENET, V20, P1037, DOI 10.1038/ejhg.2012.49
Ellis DI, 2007, PHARMACOGENOMICS, V8, P1243, DOI 10.2217/14622416.8.9.1243
Erlich Y, 2011, TWIN RES HUM GENET, V14, P137, DOI 10.1375/twin.14.2.137
Falconer DS, 1960, INTRO QUANTITATIVE G
Faraone SV, 2005, BIOL PSYCHIAT, V57, P1313, DOI 10.1016/j.biopsych.2004.11.024
Forsberg LA, 2012, AM J HUM GENET, V90, P217, DOI 10.1016/j.ajhg.2011.12.009
Fraga MF, 2005, P NATL ACAD SCI USA, V102, P10604, DOI 10.1073/pnas.0500398102
FRIBERG L, 1970, ARCH ENVIRON HEALTH, V21, P508
Galetzka D, 2012, EPIGENETICS-US, V7, P47, DOI 10.4161/epi.7.1.18814
Galton F., 1875, J ANTHR I, V5, P391
Gao Y, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0033503
Gertz J, 2011, PLOS GENET, V7, DOI 10.1371/journal.pgen.1002228
Gervin K, 2012, PLOS GENET, V8, DOI 10.1371/journal.pgen.1002454
Gordon L, 2011, EPIGENETICS-US, V6, P579, DOI 10.4161/epi.6.5.15072
Haas CS, 2006, ARTHRITIS RHEUM, V54, P2047, DOI 10.1002/art.21953
Halfvarson J, 2011, INFLAMM BOWEL DIS, V17, P6, DOI 10.1002/ibd.21295
Harder A, 2010, TWIN RES HUM GENET, V13, P582, DOI 10.1375/twin.13.6.582
Hawkes CH, 2009, MULT SCLER, V15, P661, DOI 10.1177/1352458509104592
Haworth CMA, 2010, MOL PSYCHIATR, V15, P1112, DOI 10.1038/mp.2009.55
Heijmans BT, 2007, HUM MOL GENET, V16, P547, DOI 10.1093/hmg/ddm/010
Hjelmborg JV, 2006, HUM GENET, V119, P312, DOI 10.1007/s00439-006-0144-y
Hyttinen V, 2003, DIABETES, V52, P1052, DOI 10.2337/diabetes.52.4.1052
Ingebrigtsen TS, 2011, LUNG, V189, P323, DOI 10.1007/s00408-011-9306-3
Javierre BM, 2010, GENOME RES, V20, P170, DOI 10.1101/gr.100289.109
JINKS JL, 1970, PSYCHOL BULL, V73, P311, DOI 10.1037/h0029135
Jorgensen G., 1974, ERBGEFUGE, P581
Kakiuchi C, 2008, AM J MED GENET B, V147B, P557, DOI 10.1002/ajmg.b.30643
Kaminsky ZA, 2009, NAT GENET, V41, P240, DOI 10.1038/ng.286
KAPRIO J, 1992, DIABETOLOGIA, V35, P1060, DOI 10.1007/BF02221682
Kato BS, 2011, PROTEOME SCI, V9, DOI 10.1186/1477-5956-9-73
KENDLER KS, 1987, ARCH GEN PSYCHIAT, V44, P451
Kendler KS, 2007, PSYCHOL MED, V37, P615, DOI 10.1017/S0033291706009524
Kendler KS, 1999, ARCH GEN PSYCHIAT, V56, P39, DOI 10.1001/archpsyc.56.1.39
KENDLER KS, 1986, AM J PSYCHIAT, V143, P279
Kettunen J, 2012, NAT GENET, V44, P269, DOI 10.1038/ng.1073
Kim VN, 2005, NAT REV MOL CELL BIO, V6, P376, DOI 10.1038/nrm1644
Koten JW, 2009, SCIENCE, V323, P1737, DOI 10.1126/science.1167371
Kuratomi G, 2008, MOL PSYCHIATR, V13, P429, DOI 10.1038/sj.mp.4002001
Laborie LB, 2010, EUR J PEDIATR, V169, P207, DOI 10.1007/s00431-009-1008-y
Lepage P, 2011, GASTROENTEROLOGY, V141, P227, DOI 10.1053/j.gastro.2011.04.011
Levy F, 1997, J AM ACAD CHILD PSY, V36, P737, DOI 10.1097/00004583-199706000-00009
Li MD, 2003, ADDICTION, V98, P23, DOI 10.1046/j.1360-0443.2003.00295.x
Lichtenstein P, 2000, NEW ENGL J MED, V343, P78, DOI 10.1056/NEJM200007133430201
Ligthart L, 2010, HEADACHE, V50, P1549, DOI 10.1111/j.1526-4610.2010.01705.x
Llewellyn CH, 2010, AM J CLIN NUTR, V91, P1172, DOI 10.3945/ajcn.2009.28868
Lundqvist E, 2007, INT J CANCER, V121, P810, DOI 10.1002/ijc.22746
Lundstrom S, 2012, ARCH GEN PSYCHIAT, V69, P46, DOI 10.1001/archgenpsychiatry.2011.144
MacGregor AJ, 2000, ARTHRITIS RHEUM, V43, P30, DOI 10.1002/1529-0131(200001)43:1<30::AID-ANR5>3.0.CO;2-B
MAGNUS P, 1985, EARLY HUM DEV, V12, P55, DOI 10.1016/0378-3782(85)90137-9
Maher B, 2008, NATURE, V456, P18, DOI 10.1038/456018a
MARTIN NG, 1978, HEREDITY, V40, P97, DOI 10.1038/hdy.1978.10
Martin N G, 1982, Prog Clin Biol Res, V103 Pt A, P365
MARTIN NG, 1977, HEREDITY, V38, P79, DOI 10.1038/hdy.1977.9
Mastroeni D, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0006617
Matigian N, 2007, MOL PSYCHIATR, V12, P815, DOI 10.1038/sj.mp.4001998
Mattay VS, 2008, BIOL PSYCHOL, V79, P9, DOI 10.1016/j.biopsycho.2008.03.015
Mattick JS, 2006, HUM MOL GENET, V15, pR17, DOI 10.1093/hmg/ddl046
Mayo O, 2009, TWIN RES HUM GENET, V12, P237, DOI 10.1375/twin.12.3.237
Mcrae AF, 2007, HUM MOL GENET, V16, P364, DOI 10.1093/hmg/ddl456
Middeldorp CM, 2005, TWIN RES HUM GENET, V8, P224, DOI 10.1375/1832427054253130
Middeldorp CM, 2005, PSYCHOL MED, V35, P611, DOI 10.1017/S003329170400412X
Mulder EJ, 2003, TWIN RES, V6, P422, DOI 10.1375/136905203770326420
Mustelin L., 2008, INT J OBESITY, V33, P29
NANCE WE, 1983, AM J HUM GENET, V35, P1211
Nguyen A, 2010, FASEB J, V24, P3036, DOI [10.1096/fj.10-154484, 10.1096/fj.09-154484]
Nica AC, 2011, PLOS GENET, V7, DOI 10.1371/journal.pgen.1002003
Nicholson G, 2011, MOL SYST BIOL, V7, DOI 10.1038/msb.2011.57
Nicholson G, 2011, PLOS GENET, V7, DOI 10.1371/journal.pgen.1002270
Oates NA, 2006, AM J HUM GENET, V79, P155, DOI 10.1086/505031
Ollikainen M, 2010, HUM MOL GENET, V19, P4176, DOI 10.1093/hmg/ddq336
Ott J, 2011, NAT REV GENET, V12, P465, DOI 10.1038/nrg2989
Peacock M, 2002, ENDOCR REV, V23, P303, DOI 10.1210/er.23.3.303
Pedersen NL, 2004, ANN NEUROL, V55, P180, DOI 10.1002/ana.10999
Peltonen L, 2003, TWIN RES, V6, P354, DOI 10.1375/136905203770326358
Peper JS, 2007, HUM BRAIN MAPP, V28, P464, DOI 10.1002/hbm.20398
Pietilainen KH, 2011, PLOS BIOL, V9, DOI 10.1371/journal.pbio.1000623
Pietilainen KH, 2007, PLOS ONE, V2, DOI 10.1371/journal.pone.0000218
Pietilainen KH, 2008, PLOS MED, V5, DOI 10.1371/journal.pmed.0050051
Posthuma D, 2000, BEHAV GENET, V30, P147, DOI 10.1023/A:1001959306025
Powell JE, 2012, GENOME RES, V22, P456, DOI 10.1101/gr.126540.111
Purcell S, 2002, TWIN RES, V5, P554, DOI 10.1375/136905202762342035
Rahman I, 2009, TWIN RES HUM GENET, V12, P286, DOI 10.1375/twin.12.3.286
Reynolds CA, 1996, BEHAV GENET, V26, P73, DOI 10.1007/BF02359886
Ronkainen PHA, 2009, J APPL PHYSIOL, V107, P25, DOI 10.1152/japplphysiol.91518.2008
Rosa A, 2008, AM J MED GENET B, V147B, P459, DOI 10.1002/ajmg.b.30616
Rosenberg RE, 2009, ARCH PEDIAT ADOL MED, V163, P907, DOI 10.1001/archpediatrics.2009.98
Sarachana T, 2010, GENOME MED, V2, DOI 10.1186/gm144
Scheet P., TWIN RES HU IN PRESS
Schousboe K, 2003, TWIN RES, V6, P409, DOI 10.1375/136905203770326411
Siemens HW, 1924, MOL GEN GENET, V35, P311
Silventoinen K, 2003, TWIN RES, V6, P399, DOI 10.1375/136905203770326402
SMITH C, 1970, ANN HUM GENET, V34, P85, DOI 10.1111/j.1469-1809.1970.tb00223.x
Spector T. D., 2004, OSTEOARTHR CARTILAGE, V12, P39, DOI 10.1016/j.joca.2003.09.005
Spor A, 2011, NAT REV MICROBIOL, V9, P279, DOI 10.1038/nrmicro2540
Stewart JA, 2005, J MED MICROBIOL, V54, P1239, DOI 10.1099/jmm.0.46189-0
Stubbe JH, 2006, PLOS ONE, V1, DOI 10.1371/journal.pone.0000022
Sullivan PF, 2000, AM J PSYCHIAT, V157, P1552, DOI 10.1176/appi.ajp.157.10.1552
Sullivan PF, 2003, ARCH GEN PSYCHIAT, V60, P1187, DOI 10.1001/archpsyc.60.12.1187
Talens RP, 2012, AGING CELL, V11, P694, DOI 10.1111/j.1474-9726.2012.00835.x
Tan QH, 2005, HUM GENET, V117, P267, DOI 10.1007/s00439-005-1308-x
Tanner CM, 1999, JAMA-J AM MED ASSOC, V281, P341, DOI 10.1001/jama.281.4.341
Tazi L, 2011, BMC EVOL BIOL, V11, DOI 10.1186/1471-2148-11-62
Te JL, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0010344
Teucher B, 2007, TWIN RES HUM GENET, V10, P734, DOI 10.1375/twin.10.5.734
Thomsen SF, 2010, CLIN EXP ALLERGY, V40, P1054, DOI 10.1111/j.1365-2222.2010.03525.x
Tsang TM, 2006, J PROTEOME RES, V5, P756, DOI 10.1021/pr0503782
Turnbaugh PJ, 2008, NATURE, V457, P480, DOI DOI 10.1038/NATURE07540
Vadlamudi L, 2010, NEW ENGL J MED, V363, P1335, DOI 10.1056/NEJMoa0910752
van Beijsterveldt CEM, 2002, BIOL PSYCHOL, V61, P111, DOI 10.1016/S0301-0511(02)00055-8
van der Schot AC, 2009, ARCH GEN PSYCHIAT, V66, P142, DOI 10.1001/archgenpsychiatry.2008.541
vanDijk BA, 1996, AM J MED GENET, V61, P264, DOI 10.1002/(SICI)1096-8628(19960122)61:3<264::AID-AJMG11>3.0.CO;2-R
van Grootheest DS, 2008, PSYCHOL MED, V38, P1731, DOI 10.1017/S0033291708003024
Veenma D, 2012, EUR J HUM GENET, V20, P298, DOI 10.1038/ejhg.2011.194
Veltman JA, 2012, NAT REV GENET, V13, P565, DOI 10.1038/nrg3241
Vink JM, 2011, EUR J HUM GENET, V19, P108, DOI 10.1038/ejhg.2010.139
Vinkhuyzen AAE, 2010, GENES BRAIN BEHAV, V9, P276, DOI 10.1111/j.1601-183X.2009.00554.x
Visscher PM, 2012, AM J HUM GENET, V90, P7, DOI 10.1016/j.ajhg.2011.11.029
Visscher PM, 2007, AM J HUM GENET, V81, P1104, DOI 10.1086/522934
Visscher PM, 2008, NAT REV GENET, V9, P255, DOI 10.1038/nrg2322
Vrieze SI, 2011, PLOS GENET, V7, DOI 10.1371/journal.pgen.1002413
Willer CJ, 2003, P NATL ACAD SCI USA, V100, P12877, DOI 10.1073/pnas.1932604100
Willing BP, 2010, GASTROENTEROLOGY, V139, P1844, DOI 10.1053/j.gastro.2010.08.049
Wirdefeldt K., 2011, NEUROBIOL AGING, V32, P1923
Wong CCY, 2010, EPIGENETICS-US, V5, DOI 10.4161/epi.5.6.12226
Wray Naomi R, 2008, Novartis Found Symp, V293, P48
Yang JA, 2010, NAT GENET, V42, P565, DOI 10.1038/ng.608
York TP, 2005, TWIN RES HUM GENET, V8, P5, DOI 10.1375/twin.8.1.5
Zdravkovic S, 2002, J INTERN MED, V252, P247, DOI 10.1046/j.1365-2796.2002.01029.x
Zhang SC, 2009, OBESITY, V17, P1581, DOI 10.1038/oby.2009.125
Zhu G, 2007, EUR J HUM GENET, V15, P94, DOI 10.1038/sj.ejhg.5201729
Zoetendal Erwin G., 2001, Microbial Ecology in Health and Disease, V13, P129, DOI 10.1080/089106001750462669
Zuk O, 2012, P NATL ACAD SCI USA, V109, P1193, DOI 10.1073/pnas.1119675109
Zwijnenburg PJG, 2010, AM J MED GENET B, V153B, P1134, DOI 10.1002/ajmg.b.31091
NR 155
TC 69
Z9 70
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1471-0056
EI 1471-0064
J9 NAT REV GENET
JI Nat. Rev. Genet.
PD SEP
PY 2012
VL 13
IS 9
BP 640
EP 653
DI 10.1038/nrg3243
PG 14
WC Genetics & Heredity
SC Genetics & Heredity
GA 996DJ
UT WOS:000308064000011
PM 22847273
ER
PT J
AU Wylie, M
AF Wylie, Mark
TI Working with Parents of a Newly Diagnosed Child with an Autism Spectrum
Disorder
SO PSYCHOLOGIST
LA English
DT Book Review
CR Keen D, 2012, WORKING PARENTS NEWL
NR 1
TC 0
Z9 0
PU BRITISH PSYCHOLOGICAL SOC
PI LEICESTER
PA ST ANDREWS HOUSE, 48 PRINCESS RD EAST, LEICESTER LE1 7DR, LEICS, ENGLAND
SN 0952-8229
J9 PSYCHOLOGIST
JI Psychologist
PD SEP
PY 2012
VL 25
IS 9
BP 695
EP 695
PG 1
WC Psychology, Multidisciplinary
SC Psychology
GA 002FC
UT WOS:000308516400042
ER
PT J
AU Ridgers, ND
Salmon, J
Parrish, AM
Stanley, RM
Okely, AD
AF Ridgers, Nicola D.
Salmon, Jo
Parrish, Anne-Maree
Stanley, Rebecca M.
Okely, Anthony D.
TI Physical Activity During School Recess A Systematic Review
SO AMERICAN JOURNAL OF PREVENTIVE MEDICINE
LA English
DT Review
ID ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; NORWEGIAN SECONDARY-SCHOOLS;
AUTISM SPECTRUM DISORDERS; ELEMENTARY-SCHOOL; INTELLECTUAL DISABILITIES;
MENTAL-RETARDATION; ACTIVITY PATTERNS; AGED CHILDREN; YOUTH; TIME
AB Context: Interest has increased in examining the physical activity levels of young people during school recess. Identifying correlates of their recess physical activity behaviors is timely, and would inform school-based physical activity programming and intervention development. The review examined the correlates of children's and adolescent's physical activity during school recess periods.
Evidence acquisition: Asystematic search of six electronic databases, reference lists, and personal archives identified 53 studies (47 focused on children) published between January 1990 and April 2011 that met the inclusion criteria. Data were analyzed in 2011. Correlates were categorized using the social-ecological framework.
Evidence synthesis: Forty-four variables were identified across the four levels of the social-ecological framework, although few correlates were studied repeatedly at each level. Positive associations were found of overall facility provision, unfixed equipment, and perceived encouragement with recess physical activity. Results revealed that boys were more active than girls.
Conclusions: Providing access to school facilities, providing unfixed equipment, and identifying ways to promote encouragement for physical activity have the potential to inform strategies to increase physical activity levels during recess periods. (Am J Prev Med 2012;43(3):320-328) (C) 2012 American Journal of Preventive Medicine
C1 [Ridgers, Nicola D.; Salmon, Jo] Deakin Univ, Ctr Phys Act & Nutr Res, Melbourne, Vic, Australia.
[Parrish, Anne-Maree] Univ Wollongong, Fac Hlth & Behav Sci, Wollongong, NSW, Australia.
[Okely, Anthony D.] Univ Wollongong, Interdisciplinary Educ Res Inst, Wollongong, NSW, Australia.
[Stanley, Rebecca M.] Univ S Australia, Hlth & Use Time Grp, Sch Hlth Sci, Adelaide, SA 5001, Australia.
RP Ridgers, ND (reprint author), Deakin Univ, Ctr Phys Act & Nutr Res, 221 Burwood Highway, Burwood 3125, Australia.
EM nicky.ridgers@deakin.edu.au
RI Ridgers, Nicola/B-2092-2013
FU Alfred Deakin Postdoctoral Research Fellowship; National Heart
Foundation of Australia; sanofi-aventis; Australian Postgraduate Award
Scholarship; University of South Australia
FX Nicola Ridgers is supported by an Alfred Deakin Postdoctoral Research
Fellowship. Jo Salmon is supported by a National Heart Foundation of
Australia and sanofi-aventis Career Development Award. Rebecca Stanley
is supported by an Australian Postgraduate Award Scholarship and a
University of South Australia Top Up Scholarship.
CR Andersen LB, 2006, LANCET, V368, P299, DOI 10.1016/S0140-6736(06)69075-2
Barfield JP, 2004, MEAS PHYS ED EXERC S, V8, P109, DOI 10.1207/s15327841mpee0802_5
Beighle A, 2006, J SCHOOL HEALTH, V76, P516, DOI 10.1111/j.1746-1561.2006.00151.x
Blatchford P, 2003, BRIT J DEV PSYCHOL, V21, P481, DOI 10.1348/026151003322535183
Boyle DE, 2003, AM BEHAV SCI, V46, P1326, DOI 10.1177/0002764203251474
Brusseau TA, 2011, J PHYS ACT HEALTH, V8, P279
Dale D, 2000, RES Q EXERCISE SPORT, V71, P240
Duncan JS, 2009, J SCI MED SPORT, V12, P583, DOI 10.1016/j.jsams.2008.09.010
Dyment JE, 2009, CHILD GEOGR, V7, P261, DOI 10.1080/14733280903024423
Evans J, 1996, RES EDUC, V56, P49
Faison-Hodge J., 2004, ADAPTED PHYS ACTIVIT, V21, P139
Fjortoft I, 2009, LANDSCAPE URBAN PLAN, V93, P210, DOI 10.1016/j.landurbplan.2009.07.008
Foley JT, 2008, J DEV PHYS DISABIL, V20, P365, DOI 10.1007/s10882-008-9103-y
Gavarry O, 1998, EUR J APPL PHYSIOL O, V77, P125
Ginsburg KR, 2007, PEDIATRICS, V119, P182, DOI 10.1542/peds.2006-2697
Gonzalez-Suarez CB, 2009, J SCHOOL HEALTH, V79, P304, DOI 10.1111/j.1746-1561.2009.00414.x
Haug E, 2008, INT J BEHAV NUTR PHY, V5, DOI 10.1186/1479-5868-5-47
Haug E, 2010, HEALTH PROMOT INT, V25, P63, DOI 10.1093/heapro/dap040
Haug E, 2010, HEALTH EDUC RES, V25, P248, DOI 10.1093/her/cyn050
Hinkley T, 2008, AM J PREV MED, V34, P435, DOI 10.1016/j.amepre.2008.02.001
Hohepa M, 2009, J SCI MED SPORT, V12, P284, DOI 10.1016/j.jsams.2007.11.005
Hohepa M, 2007, INT J BEHAV NUTR PHY, V4, DOI 10.1186/1479-5868-4-54
Horvat M, 2001, RES Q EXERCISE SPORT, V72, P189
Huberty JL, 2011, J SCHOOL HEALTH, V81, P251, DOI 10.1111/j.1746-1561.2011.00591.x
Jago R, 2004, PREV MED, V39, P157, DOI 10.1016/j.ypmed.2004.01.014
Jennings-Aburto N, 2009, SALUD PUBLICA MEXICO, V51, P141, DOI 10.1590/S0036-36342009000200010
Joens-Matre RR, 2008, J RURAL HEALTH, V24, P49, DOI 10.1111/j.1748-0361.2008.00136.x
Jones NR, 2010, HEALTH PLACE, V16, P776, DOI 10.1016/j.healthplace.2010.04.002
Lee SM, 2007, J SCHOOL HEALTH, V77, P435, DOI 10.1111/j.1746-1561.2007.00229.x
Lopes V., 2006, International Electronic Journal of Health Education, V9, P192
Lubans DR, 2010, SPORTS MED, V40, P1019, DOI 10.2165/11536850-000000000-00000
Martinez-Gomez D, 2010, PEDIATR EXERC SCI, V22, P218
McKenzie TL, 1997, RES Q EXERCISE SPORT, V68, P195
McKenzie TL, 2010, J SCHOOL HEALTH, V80, P470, DOI 10.1111/j.1746-1561.2010.00530.x
McLaughlin E, 2002, J HUM MOVEMENT STUD, V42, P91
Mota J, 2005, J SPORT SCI, V23, P269, DOI 10.1080/02640410410001730124
National Association for Sport and Physical Education (NASPE), 2006, REC EL SCH STUD POS
Pan CY, 2008, J AUTISM DEV DISORD, V38, P1292, DOI 10.1007/s10803-007-0518-6
Pan CY, 2008, ADAPT PHYS ACT Q, V25, P308
Parrish AM, 2009, J PHYS ACT HEALTH, V6, pS89
Parrish AM, 2009, BR J SCH NURS, V4, P6
Pellegrini A. D., 2005, ED RES, V34, P13, DOI DOI 10.3102/0013189X034001013
Pitetti KH, 2009, MED SCI SPORT EXER, V41, P1580, DOI 10.1249/MSS.0b013e31819d4438
Ramstetter CL, 2010, J SCHOOL HEALTH, V80, P517, DOI 10.1111/j.1746-1561.2010.00537.x
Ridgers ND, 2012, BRIT J SPORT MED, V46, P741, DOI 10.1136/bjsm.2011.084921
Ridgers ND, 2005, PEDIATR EXERC SCI, V17, P281
Ridgers ND, 2007, INT J BEHAV NUTR PHY, V4, DOI 10.1186/1479-5868-4-19
Ridgers ND, 2010, INT J BEHAV NUTR PHY, V7, DOI 10.1186/1479-5868-7-74
Ridgers ND, 2005, PREV MED, V41, P102, DOI 10.1016/j.ypmed.2004.10.023
Ridgers ND, 2006, PREV MED, V42, P372, DOI 10.1016/j.ypmed.2006.01.017
Ridgers ND, 2010, J PHYS ACT HEALTH, V7, P17
Ridgers ND, 2006, SPORTS MED, V36, P359, DOI 10.2165/00007256-200636040-00005
Ridgers ND, 2009, PREV MED, V49, P410, DOI 10.1016/j.ypmed.2009.08.008
Ridgers ND, 2010, J PHYS ACT HEALTH, V7, P167
Robert Wood Johnson Foundation (RWJF), 2007, REC RUL WHY UND PLAY
Rothon C, 2010, BMC MED, V8, DOI 10.1186/1741-7015-8-32
Sallis JF, 2000, MED SCI SPORT EXER, V32, P963
Sallis JF, 2002, HLTH BEHAV HLTH ED T, P462
Sallis JF, 2001, AM J PUBLIC HEALTH, V91, P618, DOI 10.2105/AJPH.91.4.618
Sandt DDR, 2005, ADAPT PHYS ACT Q, V22, P146
Sarkin JA, 1997, J TEACH PHYS EDUC, V17, P99
Scruggs PW, 2003, PEDIATR EXERC SCI, V15, P156
Sit CHP, 2008, ADAPT PHYS ACT Q, V25, P247
SLEAP M, 1992, RES Q EXERCISE SPORT, V63, P238
Stellino MB, 2010, J SCHOOL HEALTH, V80, P436, DOI 10.1111/j.1746-1561.2010.00525.x
Stratton G, 2007, OBESITY, V15, P1513, DOI 10.1038/oby.2007.179
Tobias JH, 2007, J BONE MINER RES, V22, P101, DOI 10.1359/JBMR.060913
Tsujii N, 2009, PSYCHIAT CLIN NEUROS, V63, P336, DOI 10.1111/j.1440-1819.2009.01948.x
Tsujii N, 2007, PSYCHIAT CLIN NEUROS, V61, P181, DOI 10.1111/j.1440-1819.2007.01634.x
Tudor-Locke C, 2006, MED SCI SPORT EXER, V38, P1732, DOI 10.1249/01.mss.0000230212.55119.98
Van der Horst K, 2007, MED SCI SPORT EXER, V39, P1241, DOI 10.1249/mss.0b013e318059bf35
Verstraete SJM, 2006, EUR J PUBLIC HEALTH, V16, P415, DOI 10.1093/eurpub/ckl008
Waring M, 2007, EUR PHYS EDUC REV, V13, P25, DOI 10.1177/1356336X07072672
Wechsler H, 2000, PREV MED, V31, pS121, DOI 10.1006/pmed.2000.0649
Willenberg LJ, 2010, J SCI MED SPORT, V13, P210, DOI [10.1016/j.jsams.2009.02.011, 10.1016/j.jsams.2009.02.01]
World Health Organization, 2010, GLOB REC PHYS ACT HL
Zask A, 2001, PREV MED, V33, P402, DOI 10.1006/pmed.2001.0905
NR 77
TC 33
Z9 34
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0749-3797
J9 AM J PREV MED
JI Am. J. Prev. Med.
PD SEP
PY 2012
VL 43
IS 3
BP 320
EP 328
DI 10.1016/j.amepre.2012.05.019
PG 9
WC Public, Environmental & Occupational Health; Medicine, General &
Internal
SC Public, Environmental & Occupational Health; General & Internal Medicine
GA 993TK
UT WOS:000307882300012
PM 22898126
ER
PT J
AU Volkmar, FR
AF Volkmar, Fred R.
TI Autism Spectrum Disorders
SO AMERICAN JOURNAL OF PSYCHIATRY
LA English
DT Book Review
C1 [Volkmar, Fred R.] Yale Univ, Sch Med, Ctr Child Study, New Haven, CT 06510 USA.
RP Volkmar, FR (reprint author), Yale Univ, Sch Med, Ctr Child Study, New Haven, CT 06510 USA.
CR Amaral D., 2011, AUTISM SPECTRUM DISO
NR 1
TC 0
Z9 0
PU AMER PSYCHIATRIC PUBLISHING, INC
PI ARLINGTON
PA 1000 WILSON BOULEVARD, STE 1825, ARLINGTON, VA 22209-3901 USA
SN 0002-953X
J9 AM J PSYCHIAT
JI Am. J. Psychiat.
PD SEP
PY 2012
VL 169
IS 9
BP 996
EP 996
DI 10.1176/appi.ajp.2012.12050583
PG 1
WC Psychiatry
SC Psychiatry
GA 998ZE
UT WOS:000308278100023
ER
PT J
AU Malaspina, D
AF Malaspina, Dolores
TI Infectious Behavior: Brain-Immune Connections in Autism, Schizophrenia,
and Depression
SO AMERICAN JOURNAL OF PSYCHIATRY
LA English
DT Book Review
C1 [Malaspina, Dolores] NYU, Sch Med, New York, NY 10003 USA.
RP Malaspina, D (reprint author), NYU, Sch Med, New York, NY 10003 USA.
CR Patterson PH, 2011, INFECTIOUS BEHAVIOR: BRAIN-IMMUNE CONNECTIONS IN AUTISM, SCHIZOPHRENIA, AND DEPRESSION, P1
NR 1
TC 0
Z9 0
PU AMER PSYCHIATRIC PUBLISHING, INC
PI ARLINGTON
PA 1000 WILSON BOULEVARD, STE 1825, ARLINGTON, VA 22209-3901 USA
SN 0002-953X
J9 AM J PSYCHIAT
JI Am. J. Psychiat.
PD SEP
PY 2012
VL 169
IS 9
BP 998
EP 998
DI 10.1176/appi.ajp.2012.11121785
PG 1
WC Psychiatry
SC Psychiatry
GA 998ZE
UT WOS:000308278100026
ER
PT J
AU Kealy, T
AF Kealy, Tara
TI Making Sense of Social Situations: How to Run a Group-Based Intervention
Program for Children with Autism Spectrum Disorders
SO CHILD AND ADOLESCENT MENTAL HEALTH
LA English
DT Book Review
CR COTUGNO J, 2011, MAKING SENSE SOCIAL
NR 1
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1475-357X
J9 CHILD ADOL MENT H-UK
JI Child Adolesc. Ment. Health
PD SEP
PY 2012
VL 17
IS 3
BP 192
EP 192
DI 10.1111/j.1475-3588.2012.680_4.x
PG 1
WC Psychology, Clinical; Pediatrics; Psychiatry
SC Psychology; Pediatrics; Psychiatry
GA 974AP
UT WOS:000306402400015
ER
PT J
AU Kuwagata, M
AF Kuwagata, Makiko
TI Current problems of in vivo developmental neurotoxicity tests and a new
in vivo approach focusing on each step of the developing central nervous
system
SO CONGENITAL ANOMALIES
LA English
DT Review
DE 5-bromo-2'-deoxyuridine; developmental neurotoxicity test; fetal brain
observation; new in vivo approach; valproic acid
ID FETAL VALPROATE SYNDROME; PRENATAL EXPOSURE; INDIVIDUAL-DIFFERENCES;
REPRODUCTIVE FUNCTION; ANIMAL-MODEL; RAT; AUTISM; BRAIN;
BROMODEOXYURIDINE; MOUSE
AB Developmental neurotoxicity (DNT) tests usually focus on postnatal indicators, such as behavior and neuropathology, for the detection of chemically induced neurodevelopmental defects in the central nervous system (CNS). However, low reliability, especially low reproducibility, of behavioral results often causes concern among scientists and the scientific community in general. Guidance of neurohistopathological examination in the DNT guideline also has some shortcomings, especially relating to the methodological aspects. Ongoing international trends in DNT tests have shifted from the use of original in vivo animal (mammalian) studies to in vitro experiments using cell cultures and/or non-mammalian species, such as fish. In vitro systems might initially be useful to screen test chemicals for their DNT potential. Although in vitro systems are employed as alternative approaches for DNT studies, the use of in vivo studies based on animal models remains an important factor when data are to be extrapolated to the human case. In this review, a new in vivo approach that focuses on histopathological observation of each developmental step of the CNS, such as proliferation of neural stem cells, migration of immature neurons, and formation of neural networks, using fetal and neonatal brains after chemical exposure is introduced, and some queries and arguments for current DNT experimental guidelines are discussed.
C1 [Kuwagata, Makiko] Food & Drug Safety Ctr, Pathol Lab, Div Toxicol, Hatano Res Inst, Hadano, Kanagawa 2578523, Japan.
[Kuwagata, Makiko] Showa Univ, Sch Med, Tokyo 142, Japan.
RP Kuwagata, M (reprint author), Food & Drug Safety Ctr, Pathol Lab, Div Toxicol, Hatano Res Inst, 729-5 Ochiai, Hadano, Kanagawa 2578523, Japan.
EM kuwagata.m@fdsc.or.jp
FU Long-range Research Initiative (LRI); Ministry of Education, Science,
and Culture of Japan
FX This study was supported by a grant of the Long-range Research
Initiative (LRI) and Grants-in Aid for Scientific research from the
Ministry of Education, Science, and Culture of Japan. The corresponding
author deeply appreciates Drs T. Ogawa and S. Shioda (Showa University,
Tokyo, Japan) for collaboration on this research through the LRI grant,
and also Dr T. Nagata (Hatano Research Institute, Food and Drug Safety
Center, Kanagawa, Japan) for continuous encouragement to conduct this
research, and Dr R. Rakwal (University of Tsukuba, Ibaraki, and Showa
University, Tokyo, Japan) for critical reading and checking of this
manuscript.
CR ARTLICH A, 1994, EUR J PEDIATR, V153, P488, DOI 10.1007/BF01957002
Bacon Y, 2004, GENES BRAIN BEHAV, V3, P196, DOI 10.1111/j.1601-183X.2004.00070.x
BATTINO D, 1992, ACTA NEUROL SCAND, V85, P204
Bayer Shirley A., 1995, P1041
Chaturvedi RK, 2006, NEUROBIOL DIS, V22, P421, DOI 10.1016/j.nbd.2005.12.008
CHRISTIANSON AL, 1994, DEV MED CHILD NEUROL, V36, P361
Crofton KM, 2011, ALTEX-ALTERN ANIM EX, V28, P9
Crofton KM, 2004, NEUROTOXICOL TERATOL, V26, P345, DOI 10.1016/j.ntt.2004.02.007
Dellu-Hagedorn F, 2005, NEUROBIOL LEARN MEM, V83, P43, DOI 10.1016/j.nlm.2004.07.002
Dowling ALS, 2001, ENDOCRINOLOGY, V142, P390, DOI 10.1210/en.142.1.390
Fiore M, 2001, NEUROSCI LETT, V309, P113, DOI 10.1016/S0304-3940(01)02045-6
Gospe SM, 1998, REPROD TOXICOL, V12, P119, DOI 10.1016/S0890-6238(97)00128-7
Ingram JL, 2000, NEUROTOXICOL TERATOL, V22, P319, DOI 10.1016/S0892-0362(99)00083-5
Katayama K, 2005, NEUROBIOL DIS, V18, P218, DOI 10.1016/j.nbd.2004.09.015
Keays DA, 2003, EUR J PHARMACOL, V480, P205, DOI 10.1016/j.ejphar.2003.08.107
Kim SK, 2007, BRAIN RES BULL, V74, P357, DOI 10.1016/j.brainresbull.2007.07.006
Kolb B, 1999, J NEUROSCI, V19, P2337
Kuwagata M, 1998, J VET MED SCI, V60, P93, DOI 10.1292/jvms.60.93
Kuwagata M, 2009, INT J DEV NEUROSCI, V27, P399, DOI 10.1016/j.ijdevneu.2009.01.006
Kuwagata M, 2007, NEUROTOXICOLOGY, V28, P780, DOI 10.1016/j.neuro.2006.07.017
Kuwagata M, 2011, CONGENIT ANOM, V51, P177, DOI 10.1111/j.1741-4520.2011.00331.x
Kuwagata M, 1998, REPROD TOXICOL, V12, P541, DOI 10.1016/S0890-6238(98)00037-9
Kuwagata M, 2004, TOXICOL LETT, V152, P63, DOI 10.1016/j.toxlet.2004.03.019
Kuwagata Makiko, 2001, Congenital Anomalies, V41, P312, DOI 10.1111/j.1741-4520.2001.tb00841.x
Laposa RR, 2004, FASEB J, V18, P896, DOI 10.1096/fj.03-0903fje
LONDEI T, 1995, BRAIN RES, V677, P61, DOI 10.1016/0006-8993(95)00137-F
MILLER MW, 1988, BRAIN RES, V457, P44, DOI 10.1016/0006-8993(88)90055-8
MORRIS SM, 1991, MUTAT RES, V258, P161, DOI 10.1016/0165-1110(91)90007-I
Nagao T, 1997, REPROD TOXICOL, V11, P663, DOI 10.1016/S0890-6238(97)00029-4
Narita M, 2010, NEUROSCI RES, V66, P2, DOI 10.1016/j.neures.2009.09.001
Narita N, 2002, PEDIATR RES, V52, P576, DOI 10.1203/01.PDR.0000028406.01104.76
NARUSE I, 1988, TERATOLOGY, V38, P87, DOI 10.1002/tera.1420380113
OECD, 2007, GUID TEST CHEM
Ogawa T, 2007, TOXICOL LETT, V174, P18, DOI 10.1016/j.toxlet.2007.08.006
Ogawa Tetsuo, 2005, Congenital Anomalies, V45, P14, DOI 10.1111/j.1741-4520.2005.00055.x
Rasalam AD, 2005, DEV MED CHILD NEUROL, V47, P551, DOI 10.1017/S0012162205001076
Rogers JM, 1997, TERATOLOGY, V55, P364
Schneider T, 2008, PSYCHONEUROENDOCRINO, V33, P728, DOI 10.1016/j.psyneuen.2008.02.011
Schneider T, 2005, NEUROPSYCHOPHARMACOL, V30, P80, DOI 10.1038/sj.npp.1300518
Sekerkova G, 2004, J COMP NEUROL, V470, P221, DOI 10.1002/cne.11016
Sills TL, 1996, EUR J PHARMACOL, V303, P177, DOI 10.1016/0014-2999(96)00161-6
SORIANO E, 1991, J HISTOCHEM CYTOCHEM, V39, P255
Stanton ME, 2007, BEHAV BRAIN RES, V176, P133, DOI 10.1016/j.bbr.2006.10.022
STROMLAND K, 1994, DEV MED CHILD NEUROL, V36, P351
Takahashi T, 1999, J NEUROSCI, V19, P10357
Ueno M, 2002, EXP TOXICOL PATHOL, V54, P91, DOI 10.1078/0940-2993-00239
US EPA, 1998, HLTH EFF GUID OPPTS
Williams G, 2001, DEV MED CHILD NEUROL, V43, P202, DOI 10.1017/S001216220100038X
Woo GH, 2006, NEUROTOXICOL TERATOL, V28, P125, DOI 10.1016/j.ntt.2005.08.002
Yamauchi H, 2004, NEUROTOXICOL TERATOL, V26, P579, DOI 10.1016/j.ntt.2004.03.010
Young R, 2008, PHARMACOL BIOCHEM BE, V88, P318, DOI 10.1016/j.pbb.2007.09.002
NR 51
TC 4
Z9 4
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0914-3505
J9 CONGENIT ANOM
JI Congenit. Anom.
PD SEP
PY 2012
VL 52
IS 3
SI SI
BP 129
EP 139
DI 10.1111/j.1741-4520.2012.00376.x
PG 11
WC Pediatrics
SC Pediatrics
GA 994QT
UT WOS:000307947000003
PM 22925213
ER
PT J
AU Attermann, J
Obel, C
Bilenberg, N
Nordenbaek, CM
Skytthe, A
Olsen, J
AF Attermann, Jorn
Obel, Carsten
Bilenberg, Niels
Nordenbaek, Claudia Maria
Skytthe, Axel
Olsen, Jorn
TI Traits of ADHD and autism in girls with a twin brother: a Mendelian
randomization study
SO EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
LA English
DT Article
DE Autism; ADHD; Instrumental variable; Epidemiology; Twins
ID ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; FETAL TESTOSTERONE;
ASPERGER-SYNDROME; GENETIC INFLUENCES; SEX-DIFFERENCES; BEHAVIOR;
EPIDEMIOLOGY; CHILD; PSYCHOPATHOLOGY; HERITABILITY
AB It has been hypothesized that prenatal exposure to testosterone may be associated with traits of attention-deficit/hyperactivity disorder (ADHD) or autism spectrum disorder (ASD). We conducted a population-based study of dizygotic female twins to elucidate this hypothesis, assuming that the sex of the co-twin influences the level of prenatal exposure to testosterone. We invited parents of 24,552 3- to 15-year-old twins to answer questionnaires on traits of ADHD and ASD. We analysed the data using a proportional odds model with sex of the co-twin as an instrumental variable for prenatal exposure to testosterone of female twins. We received responses for 6,339 girls from dizygotic twin pairs. Odds ratios for male versus female co-twin were 0.71 (95 % confidence interval 0.61-0.81) for ADHD traits and 0.74 (0.66-0.83) for ASD traits, indicating that a twin brother reduces traits of ADHD and ASD in females. In conclusion, we found that female twins with a twin brother scored significantly lower in parent-reported traits of ADHD and ASD than those with a twin sister. The reason for this may be parental reporting bias, or confounding by unmeasured variables, or a causal effect of an intrauterine environment modified by the sex of the co-twin in the opposite direction of what we expected.
C1 [Attermann, Jorn; Olsen, Jorn] Aarhus Univ, Sch Publ Hlth, Dept Epidemiol, DK-8000 Aarhus C, Denmark.
[Obel, Carsten] Aarhus Univ, Sch Publ Hlth, Dept Gen Med, DK-8000 Aarhus C, Denmark.
[Bilenberg, Niels; Nordenbaek, Claudia Maria] Univ So Denmark, Inst Publ Hlth, Child & Adolescent Psychiat Dept, Odense, Denmark.
RP Attermann, J (reprint author), Aarhus Univ, Sch Publ Hlth, Dept Epidemiol, Bartholins Alle 2, DK-8000 Aarhus C, Denmark.
EM ja@soci.au.dk
RI Attermann, Jorn/F-8978-2012; Bilenberg, Niels/I-6027-2014; Olsen,
Jorn/F-8801-2015
OI Attermann, Jorn/0000-0003-1081-9311; Olsen, Jorn/0000-0001-7462-5140
CR Achenbach TM, 2001, MANUAL ASEBA SCH AGE
Achenbach TM, 2008, J CHILD PSYCHOL PSYC, V49, P251, DOI 10.1111/j.1469-7610.2007.01867.x
Allison C, 2008, J AUTISM DEV DISORD, V38, P1414, DOI 10.1007/s10803-007-0509-7
American Psychiatric Association, 2000, DIAGN STAT MAN MENT
Atladottir HO, 2007, ARCH PEDIAT ADOL MED, V161, P193, DOI 10.1001/archpedi.161.2.193
Auyeung B, 2006, EUR J ENDOCRINOL, V155, pS123, DOI 10.1530/eje.1.02260
Auyeung B, 2010, MOL AUTISM, V1, DOI 10.1186/2040-2392-1-11
Auyeung B, 2009, PSYCHOL SCI, V20, P144, DOI 10.1111/j.1467-9280.2009.02279.x
Auyeung B, 2009, BRIT J PSYCHOL, V100, P1, DOI 10.1348/000712608X311731
Baron-Cohen S, 2005, SCIENCE, V310, P819, DOI 10.1126/science.1115455
Baron-Cohen S, 2010, PROG BRAIN RES, V186, P167, DOI 10.1016/B978-0-444-53630-3.00011-7
BaronCohen S, 1997, J CHILD PSYCHOL PSYC, V38, P813, DOI 10.1111/j.1469-7610.1997.tb01599.x
Chakrabarti B, 2009, AUTISM RES, V2, P157, DOI 10.1002/aur.80
Chapman E, 2006, SOC NEUROSCI, V1, P135, DOI 10.1080/17470910600992239
Christiansen L, 2003, TWIN RES, V6, P275, DOI 10.1375/136905203322296610
Constantino JN, 2003, J AM ACAD CHILD PSY, V42, P458, DOI 10.1097/01.CHI.0000046811.95464.21
Faraone SV, 2005, BIOL PSYCHIAT, V57, P1313, DOI 10.1016/j.biopsych.2004.11.024
Fitzpatrick R, 1998, Health Technol Assess, V2, P1
FOLSTEIN S, 1977, NATURE, V265, P726, DOI 10.1038/265726a0
Fombonne E, 2009, PEDIATR RES, V65, P591, DOI 10.1203/PDR.0b013e31819e7203
Fombonne E, 2005, J APPL RES INTELLECT, V18, P281, DOI 10.1111/j.1468-3148.2005.00266.x
GESCHWIND N, 1985, ARCH NEUROL-CHICAGO, V42, P428
Hoekstra RA, 2007, ARCH PEDIAT ADOL MED, V161, P372, DOI 10.1001/archpedi.161.4.372
Jolliffe T, 1997, J CHILD PSYCHOL PSYC, V38, P527, DOI 10.1111/j.1469-7610.1997.tb01539.x
Knickmeyer R, 2005, J CHILD PSYCHOL PSYC, V46, P198, DOI 10.1111/j.1469-7610.2004.00349.x
Lawlor DA, 2008, STAT MED, V27, P1133, DOI 10.1002/sim.3034
Lionel AC, 2011, SCI TRANSL MED, V3, DOI 10.1126/scitranslmed.3002464
Lutchmaya S, 2002, INFANT BEHAV DEV, V25, P327, DOI 10.1016/S0163-6383(02)00094-2
MEULENBERG PMM, 1991, J STEROID BIOCHEM, V39, P51, DOI 10.1016/0960-0760(91)90012-T
Nordenbaek C, 2011, EPIDEMIOL RES INT, V2011, P1, DOI DOI 10.1155/2011/412150
Ooi YP, 2011, J AUTISM DEV DISORD, V41, P1147, DOI 10.1007/s10803-010-1015-x
Pasterski VL, 2005, CHILD DEV, V76, P264, DOI 10.1111/j.1467-8624.2005.00843.x
Reiersen AM, 2008, TWIN RES HUM GENET, V11, P579, DOI 10.1375/twin.11.6.579
Reiersen AM, 2007, J CHILD PSYCHOL PSYC, V48, P464, DOI 10.1111/j.1469-7610.2006.01720.x
Rommelse NNJ, 2010, EUR CHILD ADOLES PSY, V19, P281, DOI 10.1007/s00787-010-0092-x
Rutter M, 2005, J INTELL DISABIL RES, V49, P231, DOI 10.1111/j.1365-2788.2005.00676.x
Skytthe A, 2002, TWIN RES, V5, P352
SOPER HV, 1986, J AUTISM DEV DISORD, V16, P155, DOI 10.1007/BF01531727
STEFFENBURG S, 1989, J CHILD PSYCHOL PSYC, V30, P405, DOI 10.1111/j.1469-7610.1989.tb00254.x
vom Saal F S, 1989, J Anim Sci, V67, P1824
Wing L, 1988, AUTISTIC CONTINUUM B
NR 41
TC 3
Z9 3
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1018-8827
J9 EUR CHILD ADOLES PSY
JI Eur. Child Adolesc. Psych.
PD SEP
PY 2012
VL 21
IS 9
BP 503
EP 509
DI 10.1007/s00787-012-0287-4
PG 7
WC Psychology, Developmental; Pediatrics; Psychiatry
SC Psychology; Pediatrics; Psychiatry
GA 999WT
UT WOS:000308346700004
PM 22643885
ER
PT J
AU Woodward, JF
Swigonski, NL
Ciccarelli, MR
AF Woodward, Jason F.
Swigonski, Nancy L.
Ciccarelli, Mary R.
TI Assessing the Health, Functional Characteristics, and Health Needs of
Youth Attending a Noncategorical Transition Support Program
SO JOURNAL OF ADOLESCENT HEALTH
LA English
DT Article
DE Transition to adulthood; Health care needs; Children with special health
care needs; Health care surveys; 2005-2006 National Survey of Children
with Special Health Care Needs; Health service utilization
ID CARE NEEDS; YOUNG-ADULTS; PREVENTIVE CARE; NATIONAL-SURVEY; RISK
BEHAVIORS; ADOLESCENTS; DISABILITIES; CHILDREN; PERSPECTIVES;
PERCEPTIONS
AB Purpose: To assess the health, functional characteristics, and health care service needs of youth and young adults with special health care needs attending a comprehensive, noncategorical transition program.
Methods: A self-administered survey was developed from national health surveys and clinical experience to assess concepts identified as important for successful transition to adulthood. Surveys were mailed to 198 parents of youth and young adults with special health care needs attending the transition clinic. Parents were asked about the youth's health, functional status, and health care services needed. The clinical database provided demographic and patient health characteristics. Results were compared against the 2005-2006 National Survey of Children with Special Health Care Needs.
Results: Forty-four percent of surveys were returned. Average age of youth was 17.5 (11-22) years old and diagnoses included cerebral palsy (36%), spina bifida (10%), developmental delay or Down syndrome (17%), and autism (6%). Most youth needed assistance with personal care (69%) and routine needs (91%) and used assistive devices (59%). Compared with the 2005-2006 National Survey of Children with Special Health Care Needs, parents reported higher needs for all services except mental health care and tobacco or substance use counseling. Forty three percent reported at least one unmet health need. Few parents reported the need for counseling on substance use (1%), sexual health screening (16%), nutrition (34%), and exercise (41%).
Conclusions: Youth attending our transition program had more functional limitations, poorer reported health status, different diagnosis distribution, and higher levels of needed health services. Few parents identified needs for other recommended adolescent preventive services. Transition programs should assess patient health characteristics and service needs to design effective patient-centered services. (C) 2012 Society for Adolescent Health and Medicine. All rights reserved.
C1 [Woodward, Jason F.; Ciccarelli, Mary R.] Indiana Univ Sch Med, Riley Hosp Children, Dept Pediat, Indianapolis, IN 46220 USA.
[Swigonski, Nancy L.] Indiana Univ Sch Med, Childrens Hlth Serv Res, Dept Publ Hlth, Indianapolis, IN 46220 USA.
RP Woodward, JF (reprint author), Indiana Univ Sch Med, Riley Hosp Children, Dept Pediat, 705 Riley Hosp,Dr Room 5867, Indianapolis, IN 46220 USA.
EM jfwoodwa@iupui.edu
FU Department of Pediatrics at Riley Hospital for Children; Wishard Health
Services; Indiana University Medical Group-Primary Care; Indiana State
Department of Health (ISDH, Maternal and Child Health Services)
[A70-0-069224]; Health Resources and Services Administration
[D70MC12842-02-00]; Agency for Healthcare Research and Quality [T32 HS
017588-02]
FX The authors thank Shelley Butler, Karan Mahal, Brittaney Hindman, Erin
Gladstone, and the CYACC team. CYACC is supported by the Department of
Pediatrics at Riley Hospital for Children, Wishard Health Services,
Indiana University Medical Group-Primary Care, and the Indiana State
Department of Health (ISDH, Maternal and Child Health Services grant
A70-0-069224). Dr. Ciccarelli and Dr. Swigonski are supported by a
Health Resources and Services Administration state implementation grant
(Indiana Community Integrated Systems of Services for Children and Youth
with Special Health Care Needs, D70MC12842-02-00). Dr. Woodward is
supported by an Agency for Healthcare Research and Quality training
grant (T32 HS 017588-02).
CR American Academy of Pediatrics American Academy of Family Physicians & American College of Physicians-American Society of Internal Medicine., 2002, PEDIATRICS, V110, P1304
American Academy of Pediatrics American Academy of Family Physicians American College of Physicians, 2011, PEDIATRICS, V128, P182, DOI DOI 10.1542/PEDS.2011-0969
Anderson DL, 2002, PEDIATR PULM, V33, P327, DOI 10.1002/ppul.10083
[Anonymous], 2008, HLTH READ WORK TRANS
Bianco M, 2009, INTELLECT DEV DISAB, V47, P186, DOI 10.1352/1934-9556-47.3.186
Bitsko RH, 2009, PEDIATRICS, V123, P124
Blum RW, 2001, J ADOLESCENT HEALTH, V28, P481, DOI 10.1016/S1054-139X(01)00201-4
Blumberg S. J., 2003, VITAL HLTH STAT, V1, P1
Blumberg SJ, 2008, VITAL HLTH STAT, V1, P1
[Centers for Disease Control and Prevention National Center for Health Statistics], 2007, SURV AD TRANS HLTH
Centers for Disease Control and Prevention (CDC) National Center for Health Statistics (NCHS) National Health Interview Survey, QUEST DAT REL DOC 19
*CHILD AD HLTH MEA, NAT SURV CHILDR HLTH
Child and Adolescent Health Measurement Initiative, 2010, NAT SURV CHILDR SPEC
Craig Simone L, 2007, Int J Adolesc Med Health, V19, P333
Crowley R, 2011, ARCH DIS CHILD, V96, P548, DOI 10.1136/adc.2010.202473
Devine KA, 2011, J PEDIATR PSYCHOL, V36, P277, DOI 10.1093/jpepsy/jsq093
Elster AB, 1994, AMA GUIDELINES ADOLE
Emerson Eric, 2005, J Intellect Disabil, V9, P58, DOI 10.1177/1744629505049730
EverettJones S, 2008, J SCH HLTH, V78, P298
Fredericks EM, 2010, PEDIATR TRANSPLANT, V14, P944, DOI 10.1111/j.1399-3046.2010.01349.x
Ganz ML, 2006, PEDIATRICS, V118, P1806, DOI 10.1542/peds.2006-2371
Geenen SJ, 2003, J ADOLESCENT HEALTH, V32, P225, DOI 10.1016/S1054-139X(02)00396-8
Houtrow AJ, 2007, PEDIATRICS, V119, pE821, DOI 10.1542/peds.2006-1896
Irwin CE, 2009, PEDIATRICS, V123, pE565, DOI 10.1542/peds.2008-2601
Jones SE, 2008, J SCHOOL HEALTH, V78, P252, DOI 10.1111/j.1746-1561.2008.00297.x
Lotstein DS, 2009, PEDIATRICS, V123, pE145, DOI 10.1542/peds.2008-1298
Maternal and Child Health Bureau Health Resources and Services Administration, ACH MEAS SUCC NAT AG
Mayer ML, 2004, PEDIATRICS, V113, P109
McDonagh Janet E, 2006, J Child Health Care, V10, P22, DOI 10.1177/1367493506060203
Merenstein D, 2001, FAM MED, V33, P120
Nageswaran S, 2008, PEDIATRICS, V121, P994, DOI 10.1542/peds.2007-1795
Newacheck PW, 2000, PEDIATRICS, V105, P760, DOI 10.1542/peds.105.4.760
Peter NG, 2009, PEDIATRICS, V123, P417, DOI 10.1542/peds.2008-0740
Pownall JD, 2011, AJIDD-AM J INTELLECT, V116, P205, DOI 10.1352/1944-7558-116.3.205
Reiss JG, 2005, PEDIATRICS, V115, P112, DOI 10.1542/peds.2004-1321
Rimmer JH, 2011, PREV CHRONIC DIS, V8
Scal P, 2008, J PEDIATR, V152, P471, DOI 10.1016/j.jpeds.2007.10.004
Scal P, 2002, PEDIATRICS, V110, P1315
Scal P, 2005, PEDIATRICS, V115, P1607, DOI 10.1542/peds.2004-0458
Silver EJ, 2001, AMBUL PEDIATR, V1, P314, DOI 10.1367/1539-4409(2001)001<0314:ATCUHN>2.0.CO;2
Van Walleghem N, 2008, DIABETES CARE, V31, P1529, DOI 10.2337/dc07-2247
NR 41
TC 3
Z9 3
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1054-139X
J9 J ADOLESCENT HEALTH
JI J. Adolesc. Health
PD SEP
PY 2012
VL 51
IS 3
BP 272
EP 278
DI 10.1016/j.jadohealth.2011.12.016
PG 7
WC Psychology, Developmental; Public, Environmental & Occupational Health;
Pediatrics
SC Psychology; Public, Environmental & Occupational Health; Pediatrics
GA 994QJ
UT WOS:000307945900012
PM 22921138
ER
PT J
AU van Steijn, DJ
Richards, JS
Oerlemans, AM
de Ruiter, SW
van Aken, MAG
Franke, B
Buitelaar, JK
Rommelse, NNJ
AF van Steijn, Daphne J.
Richards, Jennifer S.
Oerlemans, Anoek M.
de Ruiter, Saskia W.
van Aken, Marcel A. G.
Franke, Barbara
Buitelaar, Jan. K.
Rommelse, Nanda N. J.
TI The co-occurrence of autism spectrum disorder and
attention-deficit/hyperactivity disorder symptoms in parents of children
with ASD or ASD with ADHD
SO JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY
LA English
DT Article
DE Assortative mating; parent-of-origin effect; autism spectrum disorder;
attention-deficit; hyperactivity disorder
ID DEFICIT-HYPERACTIVITY DISORDER; PERVASIVE DEVELOPMENTAL DISORDERS;
FAMILIAL RISK; QUOTIENT AQ; POPULATION; SAMPLE; HERITABILITY;
TRANSMISSION; ASSOCIATION; ADOLESCENTS
AB Background: Autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD) share about 5072% of their genetic factors, which is the most likely explanation for their frequent co-occurrence within the same patient or family. An additional or alternative explanation for the co-occurrence may be (cross-)assortative mating, e.g., the tendency to choose a partner that is similar or dissimilar to oneself. Another issue is that of parent-of-origin effect which refers to the possibility of parents differing in the relative quantity of risk factors they transmit to the offspring. The current study sets out to examine (cross-)assortative mating and (cross-)parent-of-origin effects of ASD and ADHD in parents of children with either ASD or ASD with ADHD diagnosis. Methods: In total, 121 families were recruited in an ongoing autism-ADHD family genetics project. Participating families consisted of parents and at least one child aged between 2 and 20 years, with either autistic disorder, Asperger disorder or PDD-NOS, and one or more biological siblings. All children and parents were carefully screened for the presence of ASD and ADHD. Results: No correlations were found between maternal and paternal ASD and ADHD symptoms. Parental ASD and ADHD symptoms were predictive for similar symptoms in the offspring, but with maternal hyperactive-impulsive symptoms, but not paternal symptoms, predicting similar symptoms in daughters. ASD pathology in the parents was not predictive for ADHD pathology in the offspring, but mothers ADHD pathology was predictive for offspring ASD pathology even when corrected for maternal ASD pathology. Conclusions: Cross-assortative mating for ASD and ADHD does not form an explanation for the frequent co-occurrence of these disorders within families. Given that parental ADHD is predictive of offspring ASD but not vice versa, risk factors underlying ASD may overlap to a larger degree with risk factors underlying ADHD than vice versa. However, future research is needed to clarify this issue.
C1 [van Steijn, Daphne J.; Oerlemans, Anoek M.; Buitelaar, Jan. K.; Rommelse, Nanda N. J.] Karakter Child & Adolescent Psychiat Univ Ctr, NL-6525 GC Nijmegen, Netherlands.
[Richards, Jennifer S.; Oerlemans, Anoek M.; de Ruiter, Saskia W.; Franke, Barbara; Rommelse, Nanda N. J.] Radboud Univ Nijmegen, Dept Psychiat, Donders Inst Brain Cognit & Behav, Med Ctr, NL-6525 ED Nijmegen, Netherlands.
[van Aken, Marcel A. G.] Univ Utrecht, Dept Dev Psychol, Utrecht, Netherlands.
[Franke, Barbara] Radboud Univ Nijmegen, Dept Human Genet, Med Ctr, NL-6525 ED Nijmegen, Netherlands.
[Buitelaar, Jan. K.] Radboud Univ Nijmegen, Donders Inst Brain Cognit & Behav, Dept Cognit Neurosci, Med Ctr, NL-6525 ED Nijmegen, Netherlands.
RP van Steijn, DJ (reprint author), Karakter Child & Adolescent Psychiat Univ Ctr, Reinier Postlaan 12, NL-6525 GC Nijmegen, Netherlands.
EM d.vansteijn@karakter.com
RI Franke, Barbara/D-4836-2009; Rommelse, Nanda/D-4872-2009
OI Franke, Barbara/0000-0003-4375-6572; Rommelse, Nanda/0000-0002-1711-0359
FU Netherlands Organisation for Scientific Research (NWO) [91610024]
FX This study forms part of the Biologische oorzaken van Autisme
(BOA-project):
http://www.karakter.com/karakter_nl/32f6a9d20d03ec5bef446f1f90c5fa65.php
. We would like to thank parents, teachers and children participating in
this project. This study was partly funded by a grant assigned to Dr.
Rammelse by the Netherlands Organisation for Scientific Research (NWO
grant #91610024).
CR Anney RJL, 2008, AM J MED GENET B, V147B, P1495, DOI 10.1002/ajmg.b.30659
(APA) APA, 2000, DIAGN STAT MAN MENT
Arking DE, 2008, AM J HUM GENET, V82, P160, DOI 10.1016/j.ajhg.2007.09.015
Auyeung B, 2008, J AUTISM DEV DISORD, V38, P1230, DOI 10.1007/s10803-007-0504-z
Banerjee E, 2006, AM J MED GENET B, V141B, P361, DOI 10.1002/ajmg.b.30296
Baron-Cohen S, 2001, J AUTISM DEV DISORD, V31, P5, DOI 10.1023/A:1005653411471
Benjamini Y, 2010, J R STAT SOC B, V72, P405
Boomsma DI, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0010621
Brookes K, 2006, MOL PSYCHIATR, V11, P934, DOI 10.1038/sj.mp.4001869
Chandler S, 2007, J AM ACAD CHILD PSY, V46, P1324, DOI 10.1097/chi.0b013e31812f7d8d
Clark T, 1999, EUR CHILD ADOLES PSY, V8, P50
Conners C. K., 1999, CONNERS ADULT ADHD R
Conners C. K., 1997, CONNERS RATING SCALE
Conners C. K., 1998, CONNERS ADULT RATING
DEMPSTER AP, 1977, J ROY STAT SOC B MET, V39, P1
Fombonne E, 2009, PEDIATR RES, V65, P591, DOI 10.1203/PDR.0b013e31819e7203
Fradin D, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0012513
Frazier J. A., 2001, J ATTEN DISORD, V4, P203, DOI DOI 10.1177/108705470100400402
Freitag CM, 2007, MOL PSYCHIATR, V12, P2, DOI 10.1038/sj.mp.4001896
Goos LM, 2007, PSYCHIAT RES, V149, P1, DOI 10.1016/j.psychres.2006.08.006
Goos LM, 2009, AM J PSYCHIAT, V166, P711, DOI 10.1176/appi.ajp.2009.08040621
Hawi Z, 2005, AM J MED GENET B, V138B, P56
Hawi Z, 2010, AM J MED GENET B, V153B, P97, DOI 10.1002/ajmg.b.30960
Hoekstra RA, 2008, J AUTISM DEV DISORD, V38, P1555, DOI 10.1007/s10803-008-0538-x
Hoekstra RA, 2007, ARCH PEDIAT ADOL MED, V161, P372, DOI 10.1001/archpedi.161.4.372
Kim J. W., 2007, PSYCHIAT RES, V149, P1
Kim-Cohen J, 2005, ARCH GEN PSYCHIAT, V62, P173, DOI 10.1001/archpsyc.62.2.173
Kooij JJS, 2008, J ATTEN DISORD, V11, P445, DOI 10.1177/1087054707299367
Lauritsen MB, 2005, J CHILD PSYCHOL PSYC, V46, P963, DOI 10.1111/j.1469-7610.2004.00391.x
Le Couteur A., 2003, AUTISM DIAGNOSTIC IN
Lee DO, 2006, J CHILD ADOL PSYCHOP, V16, P737, DOI 10.1089/cap.2006.16.737
LIANG KY, 1986, BIOMETRIKA, V73, P13, DOI 10.1093/biomet/73.1.13
Maes HHM, 1998, PSYCHOL MED, V28, P1389, DOI 10.1017/S0033291798007326
Nikolas MA, 2010, J ABNORM PSYCHOL, V119, P1, DOI 10.1037/a0018010
Pamplona FA, 2009, PROG NEURO-PSYCHOPH, V33, P1153, DOI 10.1016/j.pnpbp.2009.06.012
Polanczyk G, 2007, AM J PSYCHIAT, V164, P942, DOI 10.1176/appi.ajp.164.6.942
Rommelse NNJ, 2010, EUR CHILD ADOLES PSY, V19, P281, DOI 10.1007/s00787-010-0092-x
Rommelse NNJ, 2011, NEUROSCI BIOBEHAV R, V35, P1363, DOI 10.1016/j.neubiorev.2011.02.015
Ronald A, 2008, J CHILD PSYCHOL PSYC, V49, P535, DOI 10.1111/j.1469-7610.2007.01857.x
Rowlandson PH, 2009, CHILD CARE HLTH DEV, V35, P681, DOI 10.1111/j.1365-2214.2009.00956.x
Rutter M., 2003, SOCIAL COMMUNICATION
Santosh PJ, 2004, EUR CHILD ADOLES PSY, V13, P141, DOI 10.1007/s00787-004-0372-4
Saviouk V, 2011, AM J MED GENET B, V156B, P352, DOI 10.1002/ajmg.b.31170
Simonoff E, 2008, J AM ACAD CHILD PSY, V47, P921, DOI 10.1097/CHI.0b013e318179964f
Sinzig J, 2009, J ATTEN DISORD, V13, P117, DOI 10.1177/1087054708326261
Taylor E, 1991, EPIDEMIOLOGY CHILDHO
VANDENBE.SG, 1972, BEHAV GENET, V2, P127, DOI 10.1007/BF01065686
Young S, 2005, BRIT J CLIN PSYCHOL, V44, P47, DOI 10.1348/014466504X197769
Zucker M, 2002, PSYCHOL ASSESSMENT, V14, P379, DOI 10.1037//1040-3590.14.4.379
NR 49
TC 16
Z9 16
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0021-9630
J9 J CHILD PSYCHOL PSYC
JI J. Child Psychol. Psychiatry
PD SEP
PY 2012
VL 53
IS 9
BP 954
EP 963
DI 10.1111/j.1469-7610.2012.02556.x
PG 10
WC Psychology, Developmental; Psychiatry; Psychology
SC Psychology; Psychiatry
GA 994TH
UT WOS:000307954500008
PM 22537103
ER
PT J
AU Landa, RJ
Gross, AL
Stuart, EA
Bauman, M
AF Landa, Rebecca J.
Gross, Alden L.
Stuart, Elizabeth A.
Bauman, Margaret
TI Latent class analysis of early developmental trajectory in baby siblings
of children with autism
SO JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY
LA English
DT Article
DE Autism; trajectories; broader autism phenotype
ID SPECTRUM DISORDERS; INFANTILE-AUTISM; MIXTURE-MODELS; REGRESSION; RISK;
LANGUAGE; IDENTIFICATION; ASSOCIATION; RECURRENCE; BEHAVIOR
AB Background: Siblings of children with autism (sibs-A) are at increased genetic risk for autism spectrum disorders (ASD) and milder impairments. To elucidate diversity and contour of early developmental trajectories exhibited by sibs-A, regardless of diagnostic classification, latent class modeling was used. Methods: Sibs-A (N = 204) were assessed with the Mullen Scales of Early Learning from age 6 to 36 months. Mullen T scores served as dependent variables. Outcome classifications at age 36 months included: ASD (N = 52); non-ASD social/communication delay (broader autism phenotype; BAP; N = 31); and unaffected (N = 121). Child-specific patterns of performance were studied using latent class growth analysis. Latent class membership was then related to diagnostic outcome through estimation of within-class proportions of children assigned to each diagnostic classification. Results: A 4-class model was favored. Class 1 represented accelerated development and consisted of 25.7% of the sample, primarily unaffected children. Class 2 (40.0% of the sample), was characterized by normative development with above-average nonverbal cognitive outcome. Class 3 (22.3% of the sample) was characterized by receptive language, and gross and fine motor delay. Class 4 (12.0% of the sample), was characterized by widespread delayed skill acquisition, reflected by declining trajectories. Children with an outcome diagnosis of ASD were spread across Classes 2, 3, and 4. Conclusions: Results support a category of ASD that involves slowing in early non-social development. Receptive language and motor development is vulnerable to early delay in sibs-A with and without ASD outcomes. Non-ASD sibs-A are largely distributed across classes depicting average or accelerated development. Developmental trajectories of motor, language, and cognition appear independent of communication and social delays in non-ASD sibs-A.
C1 [Landa, Rebecca J.] Johns Hopkins Univ, Ctr Autism & Related Disorders, Kennedy Krieger Inst, Sch Med, Baltimore, MD 21211 USA.
[Gross, Alden L.; Stuart, Elizabeth A.] Johns Hopkins Bloomberg Sch Publ Hlth, Baltimore, MD USA.
[Bauman, Margaret] Harvard Univ, Lurie Ctr LADDERS, Mass Gen Hosp Children, Sch Med, Baltimore, MD USA.
RP Landa, RJ (reprint author), Johns Hopkins Univ, Ctr Autism & Related Disorders, Kennedy Krieger Inst, Sch Med, 3901 Greenspring Ave, Baltimore, MD 21211 USA.
EM landa@kennedykrie-ger.org
FU National Institute of Mental Health [MH59630, U54 MH066417-04]
FX We thank the participants and staff at Kennedy Krieger Institute center
for Autism and Related Disorders and the Lurie Center/LADDERS of the
Mass General Hospital for Children for their help in data acquisition.
All authors had full access to all of the data in the study; Dr. Landa
takes responsibility for the integrity of the data; Drs. Gross and
Stuart take responsibility for the accuracy of data analysis; Dr. Bauman
takes responsibility for the integrity of the data collected at the
LurieCenter/LADDERS. Funding from the National Institute of Mental
Health, awarded to Rebecca Landa (PI): MH59630 (design; study conduct;
data collection, management, analysis, interpretation; preparation,
review, approval of manuscript), U54 MH066417-04 and Autism Speaks (data
collection). The authors have no conflicts of interest to report.
CR AKAIKE H, 1974, IEEE T AUTOMAT CONTR, VAC19, P716, DOI 10.1109/TAC.1974.1100705
Baird G, 2008, J AUTISM DEV DISORD, V38, P1827, DOI 10.1007/s10803-008-0571-9
Bhat AN, 2010, J CHILD PSYCHOL PSYC, V51, P989, DOI 10.1111/j.1469-7610.2010.02262.x
Bhat AN, 2011, PHYS THER, V91, P1116, DOI 10.2522/ptj.20100294
Brian J, 2008, AUTISM, V12, P433, DOI 10.1177/1362361308094500
Bryson SE, 2007, J AUTISM DEV DISORD, V37, P12, DOI 10.1007/s10803-006-0328-2
Colgan SE, 2006, CHILD NEUROPSYCHOL, V12, P307, DOI 10.1080/09297040600701360
Constantino JN, 2010, AM J PSYCHIAT, V167, P1349, DOI 10.1176/appi.ajp.2010.09101470
Davidovitch M, 2000, J AUTISM DEV DISORD, V30, P113, DOI 10.1023/A:1005403421141
Donders ART, 2006, J CLIN EPIDEMIOL, V59, P1087, DOI 10.1016/j.jclinepi.2006.01.014
Elliott MR, 2005, BIOSTATISTICS, V6, P119, DOI 10.1093/biostatistics/kxh022
Elsabbagh M, 2012, CURR BIOL, V22, P1
Feng ZD, 1996, J ROY STAT SOC B MET, V58, P609
Flanagan J., AM J OCCUPA IN PRESS
FOLSTEIN S, 1977, J CHILD PSYCHOL PSYC, V18, P297, DOI 10.1111/j.1469-7610.1977.tb00443.x
Fombonne E, 2001, PEDIATRICS, V108, part. no., DOI 10.1542/peds.108.4.e58
Gamliel I, 2009, J AUTISM DEV DISORD, V39, P1131, DOI 10.1007/s10803-009-0727-2
Godlberg W. A., 2003, J AUTISM DEV DISORD, V33, P607
HANSEN WB, 1990, EVALUATION REV, V14, P677, DOI 10.1177/0193841X9001400608
Haswell CC, 2009, NAT NEUROSCI, V12, P970, DOI 10.1038/nn.2356
Hoekstra RA, 2009, BRIT J PSYCHIAT, V195, P531, DOI 10.1192/bjp.bp.108.060889
Hollingshead A. A., 1975, 4 FACTOR INDEX UNPUB
KURITA H, 1985, J AM ACAD CHILD PSY, V24, P191, DOI 10.1016/S0002-7138(09)60447-7
Landa R, 2006, J CHILD PSYCHOL PSYC, V47, P629, DOI 10.1111/j.1469-7610.2006.01531.x
Landa R. J., 2011, AUTISM SPECTRUM DISO, P213
Landa RJ, 2007, ARCH GEN PSYCHIAT, V64, P853, DOI 10.1001/archpsyc.64.7.853
LITTLE RJA, 1995, J AM STAT ASSOC, V90, P1112, DOI 10.2307/2291350
Lo YT, 2001, BIOMETRIKA, V88, P767, DOI 10.1093/biomet/88.3.767
Lord C., 1999, AUTISM DIAGNOSTIC OB
Maestro S, 2005, PSYCHOPATHOLOGY, V38, P26, DOI 10.1159/000083967
Minshew NJ, 2002, NEUROPSYCHOLOGY, V16, P327, DOI 10.1037//0894-4105.16.3.327
Mullen E, 1995, MULLEN SCALES EARLY
Muthen B, 1999, BIOMETRICS, V55, P463, DOI 10.1111/j.0006-341X.1999.00463.x
Muthen B., 2004, HDB QUANTITATIVE MET, P346, DOI [10.4135/9781412986311.n19, DOI 10.4135/9781412986311.N19]
Muthen B, 2002, BIOSTATISTICS, V3, P459, DOI 10.1093/biostatistics/3.4.459
Muthen B. O., 1997, SOCIOL METHODOL, P453
Muthen L. K., 1998, MPLUS USERS GUIDE
Nylund KL, 2007, STRUCT EQU MODELING, V14, P535
Osterling JA, 2002, DEV PSYCHOPATHOL, V14, P239
Ozonoff S, 2011, PEDIATRICS, V128, pE488, DOI 10.1542/peds.2010-2825
Ozonoff S, 2005, AUTISM, V9, P461, DOI 10.1177/1362361305057880
Ozonoff S, 2010, J AM ACAD CHILD PSY, V49, P256, DOI 10.1016/j.jaac.2009.11.009
Sacco R, 2007, BMC MED GENET, V8, DOI 10.1186/1471-2350-8-11
Satorra A., 1994, PSYCHOMETRIKA, V75, P243
Schafer JL, 2002, PSYCHOL METHODS, V7, P147, DOI 10.1037//1082-989X.7.2.147
SCHWARZ G, 1978, ANN STAT, V6, P461, DOI 10.1214/aos/1176344136
Shinnar S, 2001, PEDIATR NEUROL, V24, P183
Sparrow SS, 2005, VINELAND ADAPTIVE BE
Sullivan M, 2007, J AUTISM DEV DISORD, V37, P37, DOI 10.1007/s10803-006-0335-3
Ventola P, 2007, J AUTISM DEV DISORD, V37, P425, DOI 10.1007/s10803-006-0177-z
Wang CP, 2005, J AM STAT ASSOC, V100, P1054, DOI 10.1198/016214505000000501
Werner E, 2005, J AUTISM DEV DISORD, V35, P337, DOI 10.1007/s10803-005-3301-6
Wetherby A. M., 2001, COMMUNICATION SYMBOL
Wexler K., 2001, RICE WEXLER TEST EAR
Wolff JJ, 2012, AM J PSYCHIAT
Young GS, 2009, DEVELOPMENTAL SCI, V12, P798, DOI 10.1111/j.1467-7687.2009.00833.x
Zimmerman I., 2002, PRESCHOOL LANGUAGE S, V4th
Zwaigenbaum L, 2005, INT J DEV NEUROSCI, V23, P143, DOI 10.1016/j.ijdevneu.2004.05.001
NR 58
TC 24
Z9 25
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0021-9630
J9 J CHILD PSYCHOL PSYC
JI J. Child Psychol. Psychiatry
PD SEP
PY 2012
VL 53
IS 9
BP 986
EP 996
DI 10.1111/j.1469-7610.2012.02558.x
PG 11
WC Psychology, Developmental; Psychiatry; Psychology
SC Psychology; Psychiatry
GA 994TH
UT WOS:000307954500011
PM 22574686
ER
PT J
AU Ozonoff, S
AF Ozonoff, Sally
TI Editorial: DSM-5 and autism spectrum disorders - two decades of
perspectives from the JCPP
SO JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY
LA English
DT Editorial Material
ID PERVASIVE DEVELOPMENTAL DISORDER; ASPERGER-SYNDROME; ARGUMENT; DEBATE;
CHILD; PSYCHOPATHOLOGY; VALIDITY; UTILITY; LECTURE
CR Asperger H, 1944, ARCH PSYCHIAT NERVEN, V117, P76, DOI 10.1007/BF01837709
Berger M, 2009, J CHILD PSYCHOL PSYC, V50, P2, DOI 10.1111/j.1469-7610.2008.02036.x
Bishop DVM, 2002, J CHILD PSYCHOL PSYC, V43, P917, DOI 10.1111/1469-7610.00114
Boucher J., 2011, NEUROPSYCHOLOGY AUTI, P469
Cantwell DP, 1996, J CHILD PSYCHOL PSYC, V37, P3, DOI 10.1111/j.1469-7610.1996.tb01377.x
CARON C, 1991, J CHILD PSYCHOL PSYC, V32, P1063, DOI 10.1111/j.1469-7610.1991.tb00350.x
Frith U, 2004, J CHILD PSYCHOL PSYC, V45, P672, DOI 10.1111/j.1469-7610.2004.00262.x
Ghaziuddin M, 2011, J AM ACAD CHILD PSY, V50, P192, DOI 10.1016/j.jaac.2010.11.013
Gilchrist A, 2001, J CHILD PSYCHOL PSYC, V42, P227, DOI 10.1017/S0021963001006631
GILLBERG C, 1991, J CHILD PSYCHOL PSYC, V32, P1169, DOI 10.1111/j.1469-7610.1991.tb00357.x
HAPPE F, 1991, J CHILD PSYCHOL PSYC, V32, P1167, DOI 10.1111/j.1469-7610.1991.tb00356.x
KLIN A, 1995, J CHILD PSYCHOL PSYC, V36, P1127, DOI 10.1111/j.1469-7610.1995.tb01361.x
Macintosh KE, 2004, J CHILD PSYCHOL PSYC, V45, P421, DOI 10.1111/j.1469-7610.2004.00234.x
Miller JN, 1997, J CHILD PSYCHOL PSYC, V38, P247
Prior M, 1998, J CHILD PSYCHOL PSYC, V39, P893, DOI 10.1111/1469-7610.00389
Rutter M, 1999, J CHILD PSYCHOL PSYC, V40, P169, DOI 10.1017/S0021963098003461
Skuse DH, 2012, J AM ACAD CHILD PSY, V51, P344, DOI 10.1016/j.jaac.2012.02.009
Tanguay PE, 2011, AM J PSYCHIAT, V168, P1142, DOI 10.1176/appi.ajp.2011.11071024
VOLKMAR FR, 1991, J CHILD PSYCHOL PSYC, V32, P1171, DOI 10.1111/j.1469-7610.1991.tb00358.x
NR 19
TC 3
Z9 3
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0021-9630
J9 J CHILD PSYCHOL PSYC
JI J. Child Psychol. Psychiatry
PD SEP
PY 2012
VL 53
IS 9
BP e4
EP e6
DI 10.1111/j.1469-7610.2012.02587.x
PG 3
WC Psychology, Developmental; Psychiatry; Psychology
SC Psychology; Psychiatry
GA 994TH
UT WOS:000307954500002
PM 22803685
ER
PT J
AU Wachtel, LE
Dhossche, DM
AF Wachtel, Lee Elizabeth
Dhossche, Dirk Marcel
TI Challenges of Electroconvulsive Therapy for Catatonia in Youth With
Intellectual Disabilities Another Tomato Effect?
SO JOURNAL OF ECT
LA English
DT Editorial Material
ID NMDA-RECEPTOR ENCEPHALITIS; SELF-INJURIOUS-BEHAVIOR; COGNITIVE
IMPAIRMENT; PEDIATRIC CATATONIA; CASE SERIES; ECT; AUTISM; ADOLESCENTS;
DISORDERS; ATTITUDES
C1 [Wachtel, Lee Elizabeth] Johns Hopkins Sch Med, Kennedy Krieger Inst, Baltimore, MD 21205 USA.
[Dhossche, Dirk Marcel] Univ Mississippi, Sch Med, University, MS 38677 USA.
RP Wachtel, LE (reprint author), Johns Hopkins Sch Med, Kennedy Krieger Inst, 707 N Broadway St, Baltimore, MD 21205 USA.
EM wachtel@kennedykrieger.org
CR Bailine SH, 2007, J ECT, V23, P21, DOI 10.1097/01.yct.0000263256.06421.7a
Balhara YPS, 2012, J ECT, V28, P1, DOI 10.1097/YCT.0b013e3182496014
Chakrabarti S, 2010, WORLD J BIOL PSYCHIA, V11, P525, DOI 10.3109/15622970903559925
COFFEY CE, 1988, AM J PSYCHIAT, V145, P701
Cohen D, 2000, AM J PSYCHIAT, V157, P460, DOI 10.1176/appi.ajp.157.3.460
Dalmau J, 2008, LANCET NEUROL, V7, P1091, DOI 10.1016/S1474-4422(08)70224-2
DEVANAND DP, 1991, AM J PSYCHIAT, V148, P929
Dhossche D, 2010, MED HYPOTHESES, V75, P558, DOI 10.1016/j.mehy.2010.07.029
Dhossche D, 2011, AM J PSYCHIAT, V168, P749, DOI 10.1176/appi.ajp.2011.11030471
Dhossche D, 2011, AM J PSYCHIAT, V168, P750
Dhossche DM, 2010, PEDIATR NEUROL, V43, P307, DOI 10.1016/j.pediatrneurol.2010.07.001
Duffner PK, 2004, NEUROLOGIST, V10, P293, DOI 10.1097/01.nrl.0000144287.35993.96
Duker PC, 1996, RES DEV DISABIL, V17, P293, DOI 10.1016/0891-4222(96)00014-5
Flaherty DK, 2011, ANN PHARMACOTHER, V45, P1302, DOI 10.1345/aph.1Q318
Francis A, 2010, J ECT, V26, P246, DOI 10.1097/YCT.0b013e3181fe28bd
Ghaziuddin N, 2001, J ECT, V17, P109, DOI 10.1097/00124509-200106000-00005
Ghaziuddin Neera, 2004, J Am Acad Child Adolesc Psychiatry, V43, P1521
GOODWIN JS, 1984, JAMA-J AM MED ASSOC, V251, P2387, DOI 10.1001/jama.251.18.2387
Jaarsma P, 2012, HEALTH CARE ANAL, V20, P20, DOI 10.1007/s10728-011-0169-9
Kashyape P, 2012, EUR J PAEDIATR NEURO, V16, P74, DOI 10.1016/j.ejpn.2011.07.005
Kellner C, 2011, PSYCHIAT TIMES, P28
Linscheid TR, 2002, RES DEV DISABIL, V23, P161, DOI 10.1016/S0891-4222(02)00093-8
McDonald A, 2001, J ECT, V17, P264, DOI 10.1097/00124509-200112000-00006
Ottosson JO, 2004, ETHICS ELECTROCONVUL
PACKER RJ, 1987, MED PEDIATR ONCOL, V15, P241, DOI 10.1002/mpo.2950150505
Riggio S, 2009, MT SINAI J MED, V76, P163, DOI 10.1002/msj.20097
Shorter E, 2007, SHOCK THERAPY HIST E
Unicef, 2005, SUMM REP VIOL DIS CH
Wachtel L, 2009, J ECT, V26, P70
Wachtel LE, 2010, PROG NEUROPSYCHOPHAR, V35, P301
Wachtel LE, 2010, AUTISM, V14, P349, DOI 10.1177/1362361309350135
Wachtel LE, 2009, EUR CHILD ADOLES PSY, V18, P458, DOI 10.1007/s00787-009-0754-8
Wachtel LE, 2010, MED HYPOTHESES, V75, P111, DOI 10.1016/j.mehy.2010.02.001
Wachtel LE, 2010, PROG NEURO-PSYCHOPH, V34, P581, DOI 10.1016/j.pnpbp.2010.03.012
Wachtel LE, 2011, EUR CHILD ADOLES PSY, V20, P147, DOI 10.1007/s00787-010-0155-z
WINSLADE WJ, 1984, AM J PSYCHIAT, V141, P1349
Zaw FKM, 1999, DEV MED CHILD NEUROL, V41, P843, DOI 10.1017/S001216229900167X
NR 37
TC 1
Z9 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1095-0680
J9 J ECT
JI J. ECT
PD SEP
PY 2012
VL 28
IS 3
BP 151
EP 153
DI 10.1097/YCT.0b013e31825692e2
PG 3
WC Behavioral Sciences; Psychiatry
SC Behavioral Sciences; Psychiatry
GA 997TF
UT WOS:000308188500009
PM 22914627
ER
PT J
AU Freitag, CM
Feineis-Matthews, S
Valerian, J
Teufel, K
Wilker, C
AF Freitag, Christine M.
Feineis-Matthews, Sabine
Valerian, Jennifer
Teufel, Karoline
Wilker, Christian
TI The Frankfurt early intervention program FFIP for preschool aged
children with autism spectrum disorder: a pilot study
SO JOURNAL OF NEURAL TRANSMISSION
LA English
DT Article
DE Autism spectrum disorder; Early intervention; Behaviour therapy;
Outcome; Toddlers
ID DIAGNOSTIC OBSERVATION SCHEDULE; INTENSIVE BEHAVIORAL TREATMENT;
PERVASIVE DEVELOPMENTAL DISORDER; YOUNG-CHILDREN; MENTAL-RETARDATION;
JOINT ATTENTION; GERMAN FORM; PREDICTORS; RELIABILITY; INTERVIEW
AB Different early intervention programs, developed predominantly in the US, for preschool aged children with autism spectrum disorders (ASD) have been published. Several systematic review articles including a German Health Technology Assessment on behavioural and skill-based early interventions in children with ASD reported insufficient evidence and a substantial problem of generalisability to the German context. In Germany, approx. 2-5 h early intervention is supported by social services. Here, we report the results of a 1 year pre-post pilot study on a developmentally based social pragmatic approach, the Frankfurt Early Intervention program FFIP. In FFIP, individual 2:1, behaviourally and developmentally based therapy with the child is combined with parent training and training of kindergarten teachers. Treatment frequency is 2 h/week. Outcome measures were the Vineland Adaptive Behaviour Scales II (VABS), mental age and the ADOS severity score. Improvements after 1 year were observed for the VABS socialisation scale and the mental age quotient/IQ (medium effect sizes). Results are comparable with several other studies with a similar or slightly higher therapeutic intensity implementing comparable or different early intervention methods or programs. Compared to most high-intensity programs (30-40 h/week), lower cognitive gains were observed. Results have to be replicated and assessed by a randomized-controlled study before any final conclusions can be drawn.
C1 [Freitag, Christine M.; Feineis-Matthews, Sabine; Valerian, Jennifer; Teufel, Karoline; Wilker, Christian] Goethe Univ Frankfurt, Dept Child & Adolescent Psychiat Psychosomat & Ps, D-60528 Frankfurt, Germany.
RP Freitag, CM (reprint author), Goethe Univ Frankfurt, Dept Child & Adolescent Psychiat Psychosomat & Ps, Deutschordenstr 50, D-60528 Frankfurt, Germany.
EM C.Freitag@em.uni-frankfurt.de
CR Billstedt E, 2007, J CHILD PSYCHOL PSYC, V48, P1102, DOI 10.1111/j.1469-7610.2007.01774.x
Bolte S, 2004, Z KINDER JUG-PSYCH, V32, P45, DOI 10.1024/1422-4917.32.1.45
Charman T, 2003, PHILOS T ROY SOC B, V358, P315, DOI 10.1098/rstb.2002.1199
Cohen H, 2006, J DEV BEHAV PEDIATR, V27, pS145, DOI 10.1097/00004703-200604002-00013
Dawson G, 2010, PEDIATRICS, V125, pE17, DOI 10.1542/peds.2009-0958
Delprato DJ, 2001, J AUTISM DEV DISORD, V31, P315, DOI 10.1023/A:1010747303957
Eikeseth S, 2002, BEHAV MODIF, V26, P49, DOI 10.1177/0145445502026001004
Eldevik S, 2010, BEHAV MODIF, V34, P16, DOI 10.1177/0145445509351961
Eldevik S, 2006, J AUTISM DEV DISORD, V36, P211, DOI 10.1007/s10803-005-0058-x
Fernell E, 2011, RES DEV DISABIL, V32, P2092, DOI 10.1016/j.ridd.2011.08.002
FREITAG CH, 2008, AUTISMUS SPEKTRUM ST
Freitag CM, 2010, Z KINDER JUG-PSYCH, V38, P247, DOI 10.1024/1422-4917/a000043
Gabriels RL, 2001, AUTISM, V5, P407, DOI 10.1177/1362361301005004006
Gotham K, 2009, J AUTISM DEV DISORD, V39, P693, DOI 10.1007/s10803-008-0674-3
Gotham K, 2007, J AUTISM DEV DISORD, V37, P613, DOI 10.1007/s10803-006-0280-1
Green J, 2010, LANCET, V375, P2152, DOI 10.1016/S0140-6736(10)60587-9
Howard JS, 2005, RES DEV DISABIL, V26, P359, DOI 10.1016/j.ridd.2004.09.005
Howlin P, 2004, J CHILD PSYCHOL PSYC, V45, P212, DOI 10.1111/j.1469-7610.2004.00215.x
Howlin P, 2009, AJIDD-AM J INTELLECT, V114, P23, DOI 10.1352/2009.114:23;nd41
Ingersoll B, 2010, J AUTISM DEV DISORD, V40, P1154, DOI 10.1007/s10803-010-0966-2
Kasari C, 2008, J CONSULT CLIN PSYCH, V76, P125, DOI 10.1037/0022-006X.76.1.125
LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
Magiati I, 2007, J CHILD PSYCHOL PSYC, V48, P803, DOI 10.1111/j.1469-7610.2007.01756.x
Magiati I, 2001, AUTISM, V5, P399, DOI 10.1177/1362361301005004005
Matson JL, 1996, RES DEV DISABIL, V17, P433, DOI 10.1016/S0891-4222(96)00030-3
Oosterling I, 2010, J AUTISM DEV DISORD, V40, P1447, DOI 10.1007/s10803-010-1004-0
Ospina MB, 2008, PLOS ONE, V3, DOI 10.1371/journal.pone.0003755
Peters-Scheffer N, 2010, RES DEV DISABIL, V31, P1678, DOI 10.1016/j.ridd.2010.04.008
Poustka F, 1996, PSYCHOPATHOLOGY, V29, P145
Reuner G, 2008, BAYLEY 2
Rogers SJ, 2003, J CHILD PSYCHOL PSYC, V44, P763, DOI 10.1111/1469-7610.00162
Salt J, 2002, AUTISM, V6, P33, DOI 10.1177/1362361302006001004
Siller M, 2008, DEV PSYCHOL, V44, P1691, DOI 10.1037/a0013771
Smith T, 2000, AM J MENT RETARD, V105, P269, DOI 10.1352/0895-8017(2000)105<0269:RTOIEI>2.0.CO;2
Smith T, 1997, AM J MENT RETARD, V102, P238, DOI 10.1352/0895-8017(1997)102<0238:IBTFPW>2.0.CO;2
Sparrow SS, 2005, VINELAND ADAPTIVE BE
Tellegen P. J., 2007, SNIJDERS OOMEN NONVE
Tsang SKM, 2007, J AUTISM DEV DISORD, V37, P390, DOI 10.1007/s10803-006-0199-6
Valenti Marco, 2010, Child Adolesc Psychiatry Ment Health, V4, P23, DOI 10.1186/1753-2000-4-23
Weinmann S, 2009, GMS HLTH TECHNOL ASS, V5, pDoc10
NR 41
TC 3
Z9 3
PU SPRINGER WIEN
PI WIEN
PA SACHSENPLATZ 4-6, PO BOX 89, A-1201 WIEN, AUSTRIA
SN 0300-9564
J9 J NEURAL TRANSM
JI J. Neural Transm.
PD SEP
PY 2012
VL 119
IS 9
SI SI
BP 1011
EP 1021
DI 10.1007/s00702-012-0792-0
PG 11
WC Clinical Neurology; Neurosciences
SC Neurosciences & Neurology
GA 992KC
UT WOS:000307773400004
PM 22460295
ER
PT J
AU Schroder, C
AF Schroeder, C.
TI Sleep and circadian rhythm disturbances in autism
SO JOURNAL OF SLEEP RESEARCH
LA English
DT Meeting Abstract
CT 21st Congress of the European-Sleep-Research-Society
CY SEP 04-08, 2012
CL Paris, FRANCE
SP European Sleep Res Soc
C1 [Schroeder, C.] Univ Strasbourg, Strasbourg, France.
NR 0
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0962-1105
J9 J SLEEP RES
JI J. Sleep Res.
PD SEP
PY 2012
VL 21
SU 1
SI SI
BP 1
EP 1
PG 1
WC Clinical Neurology; Neurosciences
SC Neurosciences & Neurology
GA 994VV
UT WOS:000307963200004
ER
PT J
AU Bouvier, M
Claustrat, B
Franco, P
AF Bouvier, M.
Claustrat, B.
Franco, P.
TI Melatonin treatment in autism spectrum disorders (ASD): preliminary
results
SO JOURNAL OF SLEEP RESEARCH
LA English
DT Meeting Abstract
CT 21st Congress of the European-Sleep-Research-Society
CY SEP 04-08, 2012
CL Paris, FRANCE
SP European Sleep Res Soc
C1 [Bouvier, M.; Claustrat, B.; Franco, P.] Hosp Civils Lyon, Bron, France.
NR 0
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0962-1105
J9 J SLEEP RES
JI J. Sleep Res.
PD SEP
PY 2012
VL 21
SU 1
SI SI
BP 236
EP 236
PG 1
WC Clinical Neurology; Neurosciences
SC Neurosciences & Neurology
GA 994VV
UT WOS:000307963201120
ER
PT J
AU Mao, AR
AF Mao, Alice R.
TI Factors That Contribute to Caregiver Burden for Parents of Children With
Autism Spectrum Disorder or Aftention-Deficit/Hyperactivity Disorder
SO JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
LA English
DT Editorial Material
ID SOCIAL SUPPORT; STRESS; MOTHERS; FAMILIES
C1 [Mao, Alice R.] Baylor Coll Med, Dept Psychiat, Houston, TX 77007 USA.
[Mao, Alice R.] DePelchin Childrens Ctr Houston, Houston, TX USA.
RP Mao, AR (reprint author), Baylor Coll Med, Dept Psychiat, 550 Westcott,Suite 520, Houston, TX 77007 USA.
EM Amao@bcm.edu
CR ANASTOPOULOS AD, 1992, J ABNORM CHILD PSYCH, V20, P503, DOI 10.1007/BF00916812
Bromley J, 2004, AUTISM, V8, P409, DOI 10.1177/1362361304047224
Cadman T, 2012, J AM ACAD CHILD PSY, V51, P879, DOI 10.1016/j.jaac.2012.06.017
Casado B, 2012, J GERONTOL B-PSYCHOL, V67, P331, DOI 10.1093/geronb/gbr115
Gombosi PG, 1998, PSYCHOANAL STUD CHIL, V53, P254
Hastings RP, 2005, J AUTISM DEV DISORD, V35, P635, DOI 10.1007/s10803-005-0007-8
Higgins DJ, 2005, AUTISM, V9, P125, DOI 10.1177/1362361305051403
Lecavalier L, 2006, J INTELL DISABIL RES, V50, P172, DOI 10.1111/j.1365-2788.2005.00732.x
Schieve LA, 2007, PEDIATRICS, V119, pS114, DOI 10.1542/peds.2006-2089Q
Sivberg Bengt, 2002, Int J Circumpolar Health, V61 Suppl 2, P36
Turgay A, 2012, J CLIN PSYCHIAT, V73, P192, DOI 10.4088/JCP.10m06628
Weiss MJ, 2002, AUTISM, V6, P115, DOI 10.1177/1362361302006001009
Yates ME, 1999, J GERONTOL B-PSYCHOL, V54, pP12
Yirmiya N, 2005, J CHILD PSYCHOL PSYC, V46, P69, DOI 10.1111/j.1469-7610.2004.00334.x
NR 14
TC 1
Z9 1
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0890-8567
J9 J AM ACAD CHILD PSY
JI J. Am. Acad. Child Adolesc. Psychiatr.
PD SEP
PY 2012
VL 51
IS 9
BP 864
EP 866
DI 10.1016/j.jaac.2012.07.005
PG 3
WC Psychology, Developmental; Pediatrics; Psychiatry
SC Psychology; Pediatrics; Psychiatry
GA 995ZW
UT WOS:000308054800004
PM 22917199
ER
PT J
AU Cadman, T
Eklund, H
Howley, D
Hayward, H
Clarke, H
Findon, J
Xenitidis, K
Murphy, D
Asherson, P
Glaser, K
AF Cadman, Tim
Eklund, Hanna
Howley, Deirdre
Hayward, Hannah
Clarke, Hanna
Findon, James
Xenitidis, Kiriakos
Murphy, Declan
Asherson, Philip
Glaser, Karen
TI Caregiver Burden as People With Autism Spectrum Disorder and
Attention-Deficit/Hyperactivity Disorder Transition into Adolescence and
Adulthood in the United Kingdom
SO JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
LA English
DT Article
DE caregiver burden; autism spectrum disorder;
attention-deficit/hyperactivity disorder
ID DEFICIT HYPERACTIVITY DISORDER; DIFFICULTIES QUESTIONNAIRE SDQ;
YOUNG-ADULTS; MENTAL-HEALTH; DOWN-SYNDROME; FOLLOW-UP; CHILDREN; ADHD;
COMMUNITY; STRENGTHS
AB Objective: There is increasing recognition that autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD) are associated with significant costs and burdens. However, research on their impact has focused mostly on the caregivers of young children; few studies have examined caregiver burden as children transition into adolescence and young adulthood, and no one has compared the impact of ASD to other neurodevelopmental disorders (e.g., ADHD). Method: We conducted an observational study of 192 families caring for a young person (aged 14 to 24 years) with a childhood diagnosis of ASD or ADHD (n = 101 and n = 91, respectively) in the United Kingdom. A modified stress-appraisal model was used to investigate the correlates of caregiver burden as a function of family background (parental education), primary stressors (symptoms), primary appraisal (need), and resources (use of services). Results: Both disorders were associated with a high level of caregiver burden, but it was significantly greater in ASD. In both groups, caregiver burden was mainly explained by the affected young person's unmet need. Domains of unmet need most associated with caregiver burden in both groups included depression/anxiety and inappropriate behavior. Specific to ASD were significant associations between burden and unmet needs in domains such as social relationships and major mental health problems. Conclusions: Adolescence and young adulthood are associated with high levels of caregiver burden in both disorders; in ASD, the level is comparable to that reported by persons caring for individuals with a brain injury. Interventions are required to reduce caregiver burden in this population. J. Am. Acad. Child Adolesc. Psychiatry, 2012;51(9):879-888.
C1 [Glaser, Karen] Kings Coll London, Dept Social Sci Hlth & Med, Strand WC2R 2LS, England.
[Cadman, Tim; Eklund, Hanna; Howley, Deirdre; Hayward, Hannah; Clarke, Hanna; Findon, James; Murphy, Declan; Asherson, Philip] Kings Coll London, Inst Psychiat, Strand WC2R 2LS, England.
[Xenitidis, Kiriakos] Bethlem Royal & Maudsley Hosp, Neurodev Disorders Serv, London, England.
[Xenitidis, Kiriakos] Maudsley Hosp & Inst Psychiat, Adult Attent Deficit Hyperact Disorder ADHD Serv, London, England.
RP Glaser, K (reprint author), Kings Coll London, Dept Social Sci Hlth & Med, Strand WC2R 2LS, England.
EM karen.glaser@kcl.ac.uk
FU National Institute for Health Research (NIHR) Programme Grants for
Applied Research (PGfAR); National Institute for Health Research
Biomedical Research Centre for Mental Health at King's College London;
Institute of Psychiatry; South London and Maudsley National Health
Service Foundation Trust
FX The research was funded by the National Institute for Health Research
(NIHR) Programme Grants for Applied Research (PGfAR). The authors alone
bear responsibility for the collection, analysis, and interpretation of
the data. Funding was also provided by The National Institute for Health
Research Biomedical Research Centre for Mental Health at King's College
London, Institute of Psychiatry, and South London and Maudsley National
Health Service Foundation Trust.
CR Abbeduto L, 2004, AM J MENT RETARD, V109, P237, DOI 10.1352/0895-8017(2004)109<237:PWACIM>2.0.CO;2
Able SL, 2007, PSYCHOL MED, V37, P97, DOI 10.1017/S0033291706008713
ANASTOPOULOS AD, 1992, J ABNORM CHILD PSYCH, V20, P503, DOI 10.1007/BF00916812
ANDERSON CS, 1995, STROKE, V26, P843
Baird G, 2006, LANCET, V368, P210, DOI 10.1016/S0140-6736(06)69041-7
BallabanGil K, 1996, PEDIATR NEUROL, V15, P217, DOI 10.1016/S0887-8994(96)00219-6
Barkley R, 2009, ADHD ADULTS DIAGNOSI
Barkley R. A., 2006, ATTENTION DEFICIT HY, V3rd
Barkley RA, 2004, J CHILD PSYCHOL PSYC, V45, P195, DOI 10.1111/j.1469-7610.2004.00214.x
Barnard J, 2001, IGNORED INELIGIBLE R
Baron-Cohen S, 2001, J AUTISM DEV DISORD, V31, P5, DOI 10.1023/A:1005653411471
Bedard M, 2001, GERONTOLOGIST, V41, P652
Beecham J, 1992, MEASURING MENTAL HLT, P179
Biederman J, 2008, J CLIN PSYCHIAT, V69, P1217
Biederman J, 2006, J CLIN PSYCHIAT, V67, P524
Blacher J, 2006, J INTELL DISABIL RES, V50, P184, DOI 10.1111/j.1365-2788.2005.00768.x
Bromley J, 2004, AUTISM, V8, P409, DOI 10.1177/1362361304047224
Brugha TS, 2011, ARCH GEN PSYCHIAT, V68, P459, DOI 10.1001/archgenpsychiatry.2011.38
Casado B, 2012, J GERONTOL B-PSYCHOL, V67, P331, DOI 10.1093/geronb/gbr115
Deb S, 2007, BRAIN INJURY, V21, P301, DOI 10.1080/02699050701253137
Eakin L, 2004, J Atten Disord, V8, P1, DOI 10.1177/108705470400800101
Edwin F, 2007, PSYCHIAT B, V31, P286, DOI 10.1192/pb.bp.106.012237
Faraone SV, 2006, PSYCHOL MED, V36, P159, DOI 10.1017/S003329170500471X
Goodman A, 2009, J AM ACAD CHILD PSY, V48, P400, DOI 10.1097/CHI.0b013e3181985068
Goodman R, 2000, BRIT J PSYCHIAT, V177, P534, DOI 10.1192/bjp.177.6.534
Goodman R, 2001, J AM ACAD CHILD PSY, V40, P1337, DOI 10.1097/00004583-200111000-00015
Goodman R, 1997, J CHILD PSYCHOL PSYC, V38, P581, DOI 10.1111/j.1469-7610.1997.tb01545.x
Hare DJ, 2004, AUTISM, V8, P425, DOI 10.1177/1362361304047225
Higginson IJ, 2010, J CLIN EPIDEMIOL, V63, P535, DOI 10.1016/j.jclinepi.2009.06.014
Howlin P, 2004, J CHILD PSYCHOL PSYC, V45, P212, DOI 10.1111/j.1469-7610.2004.00215.x
Kessler RC, 2006, AM J PSYCHIAT, V163, P716, DOI 10.1176/appi.ajp.163.4.716
Knapp M, 2009, AUTISM, V13, P317, DOI 10.1177/1362361309104246
Kring S. R., 2010, SOC WORK MENT HLTH, V8, P54
Kring SR, 2008, J MENT HEALTH RES IN, V1, P53, DOI 10.1080/19315860801988228
LAWTON MP, 1989, J GERONTOL, V44, pP61
Levy A, 2011, RES AUTISM SPECT DIS, V5, P1271, DOI 10.1016/j.rasd.2011.01.023
LEWIS G, 1992, PSYCHOL MED, V22, P465
LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
Lounds J, 2007, AM J MENT RETARD, V112, P401, DOI 10.1352/0895-8017(2007)112[401:TACIAA]2.0.CO;2
Marcer H, 2008, CHILD CARE HLTH DEV, V34, P564, DOI 10.1111/j.1365-2214.2008.00857.x
McGovern CW, 2005, J CHILD PSYCHOL PSYC, V46, P401, DOI 10.1111/j.1469-7610.2004.00361.x
McManus S, 2009, ADULT PSYCHIAT MORBI
Murphy K, 1996, COMPR PSYCHIAT, V37, P393, DOI 10.1016/S0010-440X(96)90022-X
National Audit Office, 2009, SUPP PEOPL AUT AD
Nicham R, 2003, J NEURAL TRANSM-SUPP, P173
PEARLIN LI, 1990, GERONTOLOGIST, V30, P583
Podolski CL, 2001, J CLIN CHILD PSYCHOL, V30, P503, DOI 10.1207/S15374424JCCP3004_07
Tehee E, 2009, J APPL RES INTELLECT, V22, P34, DOI 10.1111/j.1468-3148.2008.00437.x
Theule J, J EMOT BEHAV DISORD
Van Roy B, 2008, J CHILD PSYCHOL PSYC, V49, P1304, DOI 10.1111/j.1469-7610.2008.01942.x
Xenitidis K, 2000, BRIT J PSYCHIAT, V176, P473, DOI 10.1192/bjp.176.5.473
Yates ME, 1999, J GERONTOL B-PSYCHOL, V54, pP12
Young SJ, 2011, BMC PSYCHIATRY, V11, DOI 10.1186/1471-244X-11-32
NR 53
TC 23
Z9 23
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0890-8567
J9 J AM ACAD CHILD PSY
JI J. Am. Acad. Child Adolesc. Psychiatr.
PD SEP
PY 2012
VL 51
IS 9
BP 879
EP 888
DI 10.1016/j.jaac.2012.06.017
PG 10
WC Psychology, Developmental; Pediatrics; Psychiatry
SC Psychology; Pediatrics; Psychiatry
GA 995ZW
UT WOS:000308054800006
PM 22917201
ER
PT J
AU Hazlett, HC
Poe, MD
Lightbody, AA
Styner, M
MacFall, JR
Reiss, AL
Piven, J
AF Hazlett, Heather Cody
Poe, Michele D.
Lightbody, Amy A.
Styner, Martin
MacFall, James R.
Reiss, Allan L.
Piven, Joseph
TI Trajectories of Early Brain Volume Development in Fragile X Syndrome and
Autism
SO JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
LA English
DT Article
DE fragile X syndrome; autism; children; brain MRI; brain volume
ID FMR1 KNOCKOUT MICE; IDIOPATHIC AUTISM; YOUNG BOYS; MR-IMAGES; DISORDERS;
BEHAVIOR; CHILDHOOD; PHENOTYPE; ADULTS; AGE
AB Objective: To examine patterns of early brain growth in young children with fragile X syndrome (FXS) compared with a comparison group (controls) and a group with idiopathic autism. Method: The study included 53 boys 18 to 42 months of age with FXS, 68 boys with idiopathic autism (autism spectrum disorder), and a comparison group of 50 typically developing and developmentally delayed controls. Structural brain volumes were examined using magnetic resonance imaging across two time points, at 2 to 3 and again at 4 to 5 years of age, and total brain volumes and regional (lobar) tissue volumes were examined. In addition, a selected group of subcortical structures implicated in the behavioral features of FXS (e.g., basal ganglia, hippocampus, amygdala) was studied. Results: Children with FXS had larger global brain volumes compared with controls but were not different than children with idiopathic autism, and the rate of brain growth from 2 to 5 years of age paralleled that seen in controls. In contrast to children with idiopathic autism who had generalized cortical lobe enlargement, children with FXS showed specific enlargement in the temporal lobe white matter, cerebellar gray matter, and caudate nucleus, but a significantly smaller amygdala. Conclusions: This structural longitudinal magnetic resonance imaging study of preschoolers with FXS observed generalized brain overgrowth in children with FXS compared with controls, evident at age 2 and maintained across ages 4 to 5. In addition, different patterns of brain growth that distinguished boys with FXS from boys with idiopathic autism were found. J. Am. Acad. Child Adolesc. Psychiatry, 2012;51(9):921-933.
C1 [Hazlett, Heather Cody; Piven, Joseph] UNC, Carolina Inst Dev Disabil, Chapel Hill, NC 27599 USA.
[Poe, Michele D.] Frank Graham Child Dev Inst, Chapel Hill, NC USA.
[Lightbody, Amy A.; Reiss, Allan L.] Stanford Univ, Sch Med, Ctr Interdisciplinary Brain Sci Res, Stanford, CA 94305 USA.
[MacFall, James R.] Duke Univ, Med Ctr, Durham, NC 27706 USA.
RP Hazlett, HC (reprint author), UNC, Carolina Inst Dev Disabil, CB 3367, Chapel Hill, NC 27599 USA.
EM heother_cody@med.unc.edu
RI Poe, Michele/K-6615-2012
OI Poe, Michele/0000-0001-9693-3638
FU National Institutes of Health grants [MH64708-05, MH61696, P30 HD03110]
FX This research was supported by the National Institutes of Health grants
MH64708-05 (J.P., A.R.), MH61696 (J.P.), and P30 HD03110 (J.P.)
CR AMAN MG, 1995, AM J MENT RETARD, V100, P283
Bailey DB, 1998, J AUTISM DEV DISORD, V28, P499
Bailey DB, 2000, J AUTISM DEV DISORD, V30, P49
Baranek GT, 2005, J AUTISM DEV DISORD, V35, P645, DOI 10.1007/s10803-005-008-7
Bassell GJ, 2008, NEURON, V60, P201, DOI 10.1016/j.neuron.2008.10.004
BAUMGARDNER TL, 1995, PEDIATRICS, V95, P744
Bodfish J. W., 1999, W CAROLINA CTR RES R
BREGMAN JD, 1988, J AUTISM DEV DISORD, V18, P343, DOI 10.1007/BF02212191
DILAVORE PC, 1995, J AUTISM DEV DISORD, V25, P355, DOI 10.1007/BF02179373
Einfeld S, AM J MED GENET, V87, P436
Elliott C, 2006, DIFFERENTIAL ABILITI
Giedd JN, 1999, NAT NEUROSCI, V2, P861, DOI 10.1038/13158
Grossman AW, 2010, BRAIN RES, V1355, P221, DOI 10.1016/j.brainres.2010.07.090
Hall SS, 2010, J AM ACAD CHILD PSY, V49, P921, DOI 10.1016/j.jaac.2010.07.001
Harlow EG, 2010, NEURON, V65, P385, DOI 10.1016/j.neuron.2010.01.024
Hazlett HC, 2005, ARCH GEN PSYCHIAT, V62, P1366, DOI 10.1001/archpsyc.62.12.1366
Hazlett HC, 2009, J NEURODEV DISORD, V1, P81, DOI 10.1007/s11689-009-9009-8
Hessl D, 2004, MENT RETARD DEV D R, V10, P17, DOI 10.1002/mrdd.20004
Hoeft F, 2011, ARCH GEN PSYCHIAT, V68, P295, DOI 10.1001/archgenpsychiatry.2010.153
Hoeft F, 2008, ARCH GEN PSYCHIAT, V65, P1087, DOI 10.1001/archpsyc.65.9.1087
Hoeft F, 2010, P NATL ACAD SCI USA, V107, P9335, DOI 10.1073/pnas.1002762107
LACHIEWICZ AM, 1994, AM J MENT RETARD, V98, P567
LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
Louhivuori V, 2011, NEUROBIOL DIS, V41, P469, DOI 10.1016/j.nbd.2010.10.018
MESIBOV GB, 1989, J AM ACAD CHILD PSY, V28, P538, DOI 10.1097/00004583-198907000-00012
Mullen E, 1995, MULLEN SCALES EARLY
Polleux F, 2002, DEVELOPMENT, V129, P3147
REISS AL, 1995, NAT MED, V1, P159, DOI 10.1038/nm0295-159
Restifo LL, 2005, MENT RETARD DEV D R, V11, P286, DOI 10.1002/mrdd.20083
Rogers SJ, 2001, J DEV BEHAV PEDIATR, V22, P409
Saffary R, 2011, J NEUROSCI, V31, P1427, DOI 10.1523/JNEUROSCI.4854-10.2011
Sparrow S, 1984, VINELAND ADAPTIVE BE
Van Leemput K, 1999, IEEE T MED IMAGING, V18, P885, DOI 10.1109/42.811268
Van Leemput K, 1999, IEEE T MED IMAGING, V18, P897, DOI 10.1109/42.811270
WILLEMSEN R, 1995, LANCET, V345, P1147, DOI 10.1016/S0140-6736(95)90979-6
NR 35
TC 18
Z9 18
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0890-8567
J9 J AM ACAD CHILD PSY
JI J. Am. Acad. Child Adolesc. Psychiatr.
PD SEP
PY 2012
VL 51
IS 9
BP 921
EP 933
DI 10.1016/j.jaac.2012.07.003
PG 13
WC Psychology, Developmental; Pediatrics; Psychiatry
SC Psychology; Pediatrics; Psychiatry
GA 995ZW
UT WOS:000308054800010
PM 22917205
ER
PT J
AU Glatt, SJ
Tsuang, MT
Winn, M
Chandler, SD
Collins, M
Lopez, L
Weinfeld, M
Carter, C
Schork, N
Karen, P
Courchesne, E
AF Glatt, Stephen J.
Tsuang, Ming T.
Winn, Mary
Chandler, Sharon D.
Collins, Melanie
Lopez, Linda
Weinfeld, Melanie
Carter, Cindy
Schork, Nicholas
Pierce, Karen
Courchesne, Eric
TI Blood-Based Gene Expression Signatures of Infants and Toddlers With
Autism
SO JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
LA English
DT Article
DE autism; biomarker; classifier; microarray; support vector machine
ID LYMPHOBLASTOID CELL-LINES; SPECTRUM DISORDERS; PROFILES; VALIDITY;
BRAIN; SCHIZOPHRENIA; TRANSCRIPTOME; INDIVIDUALS; PATHWAYS; SYSTEM
AB Objective: Autism spectrum disorders (ASDs) are highly heritable neurodevelopmental disorders that onset clinically during the first years of life. ASD risk biomarkers expressed early in life could significantly impact diagnosis and treatment, but no transcriptome-wide biomarker classifiers derived from fresh blood samples from children with autism have yet emerged. Method: Using a community-based, prospective, longitudinal method, we identified 60 infants and toddlers at risk for ASDs (autistic disorder and pervasive developmental disorder), 34 at-risk for language delay, 17 at-risk for global developmental delay, and 68 typically developing comparison children. Diagnoses were confirmed via longitudinal follow-up. Each child's mRNA expression profile in peripheral blood mononuclear cells was determined by microarray. Results: Potential ASD biomarkers were discovered in one-half of the sample and used to build a classifier, with high diagnostic accuracy in the remaining half of the sample. Conclusions: The mRNA expression abnormalities reliably observed in peripheral blood mononuclear cells, which are safely and easily assayed in infants, offer the first potential peripheral blood based, early biomarker panel of risk for autism in infants and toddlers. Future work should verify these biomarkers and evaluate whether they may also serve as indirect indices of deviant molecular neural mechanisms in autism. J. Am. Acad. Child Adolesc. Psychiatry, 2012;51(9):934-944.
C1 [Glatt, Stephen J.] SUNY Upstate Med Univ, Psychiat Genet Epidemiol & Neurobiol Lab PsychGEN, Med Genet Res Ctr, Syracuse, NY 13210 USA.
[Tsuang, Ming T.] Harvard Univ, Harvard Inst Psychiat Epidemiol & Genet, Sch Publ Hlth, Cambridge, MA 02138 USA.
[Tsuang, Ming T.] Harvard Univ, Sch Med, Cambridge, MA 02138 USA.
[Tsuang, Ming T.; Chandler, Sharon D.; Collins, Melanie] Univ Calif San Diego, Ctr Behav Genom, La Jolla, CA 92093 USA.
[Tsuang, Ming T.] Univ Calif San Diego, Vet Affairs San Diego Healthcare Syst, La Jolla, CA 92093 USA.
[Tsuang, Ming T.] Univ Calif San Diego, Inst Genom Med, La Jolla, CA 92093 USA.
[Lopez, Linda; Weinfeld, Melanie; Carter, Cindy; Pierce, Karen; Courchesne, Eric] Univ Calif San Diego, Autism Ctr Excellences, La Jolla, CA 92093 USA.
[Winn, Mary; Schork, Nicholas] Univ Calif San Diego, Scripps Translat Sci Inst, La Jolla, CA 92093 USA.
RP Glatt, SJ (reprint author), SUNY Upstate Med Univ, Psychiat Genet Epidemiol & Neurobiol Lab PsychGEN, Med Genet Res Ctr, 750 E Adams St, Syracuse, NY 13210 USA.
EM glatts@upstate.edu
FU U.S. National Institutes of Health (NIH) [P50MH081755, R01MH080134,
R21MH075027, U19AG023122, R01MH078151, N01MH22005, U01DA024417,
UL1RR025774, RC2DA029475, R01AG031224, U54NS056883, P50MH081755-0003];
Price Foundation, Scripps Genomic Medicine; Sidney R. Baer, Jr.
Foundation; Brain and Behavior Research Foundation (NARSAD)
FX This work was supported in part by U.S. National Institutes of Health
(NIH) grants P50MH081755, R01MH080134, R21MH075027, U19AG023122,
R01MH078151, N01MH22005, U01DA024417, UL1RR025774, RC2DA029475,
R01AG031224, U54NS056883, and P50MH081755-0003, the Price Foundation,
Scripps Genomic Medicine, the Sidney R. Baer, Jr. Foundation, and the
Brain and Behavior Research Foundation (NARSAD).
CR [Anonymous], 2009, MMWR SURVEILL SUMM, V58, P1
Baron CA, 2006, J AUTISM DEV DISORD, V36, P973, DOI 10.1007/s10803-006-0134-x
Campbell C, 2002, DIS MARKERS, V18, P201
Chow ML, 2012, PLOS GENET, V8, DOI 10.1371/journal.pgen.1002592
Dawson G, 2010, CURR OPIN NEUROL, V23, P95, DOI 10.1097/WCO.0b013e3283377644
Dennis Glynn Jr, 2003, Genome Biol, V4, pP3, DOI 10.1186/gb-2003-4-5-p3
Eady JJ, 2005, PHYSIOL GENOMICS, V22, P402, DOI 10.1152/physiolgenomics.00080.2005
Garbett K, 2008, NEUROBIOL DIS, V30, P303, DOI 10.1016/j.nbd.2008.01.012
Glatt SJ, 2005, P NATL ACAD SCI USA, V102, P15533, DOI 10.1073/pnas.0507666102
Gotham K, 2007, J AUTISM DEV DISORD, V37, P613, DOI 10.1007/s10803-006-0280-1
Hu VW, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0005775
Karlovich C, 2009, BMC MED GENOMICS, V2, DOI 10.1186/1755-8794-2-33
Kohane IS, 2012, BIOINFORMATICS, V28, P538, DOI 10.1093/bioinformatics/btr713
Kuwano Y, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0024723
Lord C., 2001, AUTISM DIAGNOSTIC OB
Luyster R, 2009, J AUTISM DEV DISORD, V39, P1305, DOI 10.1007/s10803-009-0746-z
McLoughlin K, 2006, MOL MED, V12, P185, DOI 10.2119/2006-00018.McLoughlin
Nishimura Y, 2007, HUM MOL GENET, V16, P1682, DOI 10.1093/hmg/ddm116
Pierce K, 2011, J PEDIATR-US, V159, P458, DOI 10.1016/j.jpeds.2011.02.036
Pierce K, 2009, ANN CLIN PSYCHIATRY, V21, P132
Purcell AE, 2001, NEUROLOGY, V57, P1618
Radich JP, 2004, GENOMICS, V83, P980, DOI 10.1016/j.ygeno.2003.12.013
Rapin I, 2003, BRAIN DEV-JPN, V25, P166, DOI 10.1016/S0387-7604(02)00191-2
Schroeder A, 2006, BMC MOL BIOL, V7, DOI 10.1186/1471-2199-7-3
Seno MMG, 2011, BRAIN RES, V1380, P85, DOI 10.1016/j.brainres.2010.09.046
Sullivan PF, 2006, AM J MED GENET B, V141B, P261, DOI 10.1002/ajmg.b.30272
Tager-Flusberg H, 1999, J SPEECH LANG HEAR R, V42, P1275
Tager-Flusberg H, 2003, PHILOS T ROY SOC B, V358, P303, DOI 10.1098/rstb.2002.1198
Tager-Flusberg H, 2006, SOC COGN AFFECT NEUR, V1, P175, DOI 10.1093/scan/nsl035
Tsuang MT, 2005, AM J MED GENET B, V133B, P1, DOI 10.1002/ajmg.b.30161
Wetherby AM, 2002, J SPEECH LANG HEAR R, V45, P1202, DOI 10.1044/1092-4388(2002/097)
Wetherby AM, 2002, COMMUNICATION SYMBOL
NR 32
TC 14
Z9 14
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0890-8567
J9 J AM ACAD CHILD PSY
JI J. Am. Acad. Child Adolesc. Psychiatr.
PD SEP
PY 2012
VL 51
IS 9
BP 934
EP 944
DI 10.1016/j.jaac.2011.07.007
PG 11
WC Psychology, Developmental; Pediatrics; Psychiatry
SC Psychology; Pediatrics; Psychiatry
GA 995ZW
UT WOS:000308054800011
PM 22917206
ER
PT J
AU Goodson, B
Williamson, E
AF Goodson, Bradley
Williamson, Edwin
TI Practical Social Skills for Autism Spectrum Disorders: Designing
Child-Specific Interventions
SO JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
LA English
DT Book Review
C1 [Goodson, Bradley; Williamson, Edwin] Vanderbilt Univ, Nashville, TN 37235 USA.
RP Goodson, B (reprint author), Vanderbilt Univ, Nashville, TN 37235 USA.
EM edwin.williamson@vanderbilt.edu
CR Centers for Disease Control and Prevention Division of News and Electronic Media, CDC EST 1 88 CHILDR
Koenig K., 2012, PRACTICAL SOCIAL SKI
NR 2
TC 0
Z9 0
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0890-8567
J9 J AM ACAD CHILD PSY
JI J. Am. Acad. Child Adolesc. Psychiatr.
PD SEP
PY 2012
VL 51
IS 9
BP 954
EP 956
DI 10.1016/j.jaac.2012.07.015
PG 3
WC Psychology, Developmental; Pediatrics; Psychiatry
SC Psychology; Pediatrics; Psychiatry
GA 995ZW
UT WOS:000308054800017
ER
PT J
AU Fields, C
AF Fields, Chris
TI Do autism spectrum disorders involve a generalized object categorization
and identification dysfunction?
SO MEDICAL HYPOTHESES
LA English
DT Article
ID MIRROR NEURON SYSTEM; HIGH-FUNCTIONING AUTISM; BRAINS DEFAULT NETWORK;
BIOLOGICAL MOTION; FETAL TESTOSTERONE; CHANGE BLINDNESS;
SEX-DIFFERENCES; MIND; CONSEQUENCES; RECOGNITION
AB Experience-dependent learning of feature-based object categories, including entry-level categories such as "human being" and more specialized categories such as "family member", "pet" or "toy", is required to support correct object re-identification over time and hence to support social bonding, language learning, and the development of general life skills. It is hypothesized that activity imbalances between motion-analyzing and feature-analyzing components of the visuo-motor system resulting in hyper-activation of parahippocampal cortex relative to perirhinal cortex during the initial period of experience-dependent category learning in early infancy could lead to the construction of object categories dominated by trajectory information as opposed to feature information. It is shown that the deployment of trajectory-dominated object categories would disrupt normal object re-identification and produce developmental outcomes consistent with both the recognized symptoms and experimentally characterized cognitive-behavioral phenotypes of autism spectrum disorders. Further experiments to test the hypothesis and its potential clinical relevance are discussed. (C) 2012 Elsevier Ltd. All rights reserved.
RP Fields, C (reprint author), 815 E Palace Ave,14, Santa Fe, NM 87501 USA.
EM fieldsres@gmail.com
CR Abrahams BS, 2008, NAT REV GENET, V9, P341, DOI 10.1038/nrg2346
American Psychiatric Association, 2000, DIAGN STAT MAN MENT
Auyeung B, 2009, BRIT J PSYCHOL, V100, P1, DOI 10.1348/000712608X311731
Baillargeon R, 2008, PERSPECT PSYCHOL SCI, V3, P2, DOI 10.1111/j.1745-6916.2008.00056.x
Baron-Cohen S, 2008, Q J EXP PSYCHOL, V61, P64, DOI 10.1080/17470210701508749
Baron-Cohen S, 2002, TRENDS COGN SCI, V6, P248, DOI 10.1016/S1364-6613(02)01904-6
Baron-Cohen S, 2003, PHILOS T ROY SOC B, V358, P361, DOI 10.1098/rstb.2002.1206
Betancur C, 2011, BRAIN RES, V1380, P42, DOI 10.1016/j.brainres.2010.11.078
Boria S, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0005596
Buckner RL, 2008, ANN NY ACAD SCI, V1124, P1, DOI 10.1196/annals.1440.011
Cannell JJ, 2010, ACTA PAEDIATR, V99, P1128, DOI 10.1111/j.1651-2227.2010.01883.x
Cannell JJ, 2008, MED HYPOTHESES, V70, P750, DOI 10.1016/j.mehy.2007.08.016
Casler K, 2007, COGNITION, V103, P120, DOI 10.1016/j.cognition.2006.02.006
Chun MM, 2011, ANNU REV PSYCHOL, V62, P73, DOI 10.1146/annurev.psych.093008.100427
Chuthapisith J., 2011, AUTISM SPECTRUM DISO, P3
Currenti SA, 2010, CELL MOL NEUROBIOL, V30, P161, DOI 10.1007/s10571-009-9453-8
Dawson G, 2008, DEV PSYCHOPATHOL, V20, P775, DOI 10.1017/S0954579408000370
DeSoto MC, 2009, NEUROTOXICOLOGY, V30, P331, DOI 10.1016/j.neuro.2009.03.003
Dixon DR, 2011, AUT CHILD PSYCHO, P197, DOI 10.1007/978-1-4419-8065-6_12
Dziobek I, 2010, ARCH GEN PSYCHIAT, V67, P397, DOI 10.1001/archgenpsychiatry.2010.31
Eichenbaum H, 2007, ANNU REV NEUROSCI, V30, P123, DOI 10.1146/annurev.neuro.30.051606.094328
Fair DA, 2008, P NATL ACAD SCI USA, V105, P4028, DOI 10.1073/pnas.0800376105
Fields C, 2011, FRONT PSYCHOL, V2, DOI 10.3389/fpsyg.2011.00049
Fields C, 2012, ADV COGN PS IN PRESS
Fields C, 2011, PERS INDIV DIFFER, V50, P1159, DOI 10.1016/j.paid.2011.02.010
Fitzgerald Michael, 2007, GENIUS GENES ASPERGE
Flombaum J. I., 2008, ORIGINS OBJECT KNOWL, P135
Fombonne E, 2009, PEDIATR RES, V65, P591, DOI 10.1203/PDR.0b013e31819e7203
Freitag CM, 2008, NEUROPSYCHOLOGIA, V46, P1480, DOI 10.1016/j.neuropsychologia.2007.12.025
Frith U, 2001, NEURON, V32, P969, DOI 10.1016/S0896-6273(01)00552-9
Gallese V, 2011, PERSPECT PSYCHOL SCI, V6, P369, DOI 10.1177/1745691611413392
Gao T, 2010, VIS COGN, V18, P82, DOI 10.1080/13506280802614966
Gardener H, 2011, PEDIATRICS, V128, P344, DOI 10.1542/peds.2010-1036
Gerhardstein P., 2009, NEW DIRECTIONS DEV P, P79
Geschwind DH, 2007, CURR OPIN NEUROBIOL, V17, P103, DOI 10.1016/j.conb.2007.01.009
Geschwind DH, 2008, CELL, V135, P391, DOI 10.1016/j.cell.2008.10.016
Geschwind DH, 2009, ANNU REV MED, V60, P367, DOI 10.1146/annurev.med.60.053107.121225
Gonzalez Antonio, 2011, Dialogues Clin Neurosci, V13, P55
Gutheil G, 2008, COGNITION, V107, P366, DOI 10.1016/j.cognition.2007.07.014
Hamilton AFD, 2009, J CHILD PSYCHOL PSYC, V50, P881, DOI 10.1111/j.1469-7610.2009.02098.x
Hamilton AFD, 2007, NEUROPSYCHOLOGIA, V45, P1859, DOI 10.1016/j.neuropsychologia.2006.11.022
Happe F, 2009, PHILOS T R SOC B, V364, P1345, DOI 10.1098/rstb.2009.0009
Happe F, 2006, J AUTISM DEV DISORD, V36, P5, DOI 10.1007/s10803-005-0039-0
Happe F, 2006, NAT NEUROSCI, V9, P1218, DOI 10.1038/nn1770
Harms MB, 2010, NEUROPSYCHOL REV, V20, P290, DOI 10.1007/s11065-010-9138-6
Herrington JD, 2011, NEUROIMAGE, V56, P2348, DOI 10.1016/j.neuroimage.2011.03.072
Iacoboni M, 2006, NAT REV NEUROSCI, V7, P942, DOI 10.1038/nrn2024
Johnson MH, 2005, TRENDS COGN SCI, V9, P152, DOI 10.1016/j.tics.2005.01.009
Kaiser MD, 2010, P NATL ACAD SCI USA, V107, P21223, DOI 10.1073/pnas.1010412107
Kiefer M, 2011, CORTEX IN PRESS
Kinney DK, 2010, MED HYPOTHESES, V74, P102, DOI 10.1016/j.mehy.2009.07.052
Klin A, 2009, NATURE, V459, P257, DOI 10.1038/nature07868
Knickmeyer RC, 2006, J CHILD NEUROL, V21, P825, DOI 10.2310/7010.2006.00213
Kunda M, 2011, J AUTISM DEV DISORD, V41, P1157, DOI 10.1007/s10803-010-1137-1
Leonard H, 2010, RES AUTISM SPECT DIS, V4, P548, DOI 10.1016/j.rasd.2010.01.003
Lombardo MV, 2010, WIRES COGN SCI, V1, P393, DOI 10.1002/wcs.45
Luyster RJ, 2008, J AUTISM DEV DISORD, V38, P1426, DOI 10.1007/s10803-007-0510-1
Markram Henry, 2007, Front Neurosci, V1, P77, DOI 10.3389/neuro.01.1.1.006.2007
Marsh LE, 2011, NEUROIMAGE, V56, P1511, DOI 10.1016/j.neuroimage.2011.02.003
Martin A, 2007, ANNU REV PSYCHOL, V58, P25, DOI 10.1146/annurev.psych.57.102904.190143
Martinez-Pedraza FD, 2009, CHILD ADOL PSYCH CL, V18, P645, DOI 10.1016/j.chc.2009.02.002
Matson JL, 2011, RES AUTISM SPECT DIS, V5, P418, DOI 10.1016/j.rasd.2010.06.004
Miles J. H., 2011, AUTISM SPECTRUM DISO, P705
Miles JH, 2011, GENET MED, V13, P278, DOI 10.1097/GIM.0b013e3181ff67ba
Monk CS, 2009, NEUROIMAGE, V47, P764, DOI 10.1016/j.neuroimage.2009.04.069
Nassi JJ, 2009, NAT REV NEUROSCI, V10, P360, DOI 10.1038/nrn2619
Oberman LM, 2007, PSYCHOL BULL, V133, P310, DOI 10.1037/0033-2909.133.2.310
Odom SL, 2010, J AUTISM DEV DISORD, V40, P425, DOI 10.1007/s10803-009-0825-1
Ospina MB, 2008, PLOS ONE, V3, DOI 10.1371/journal.pone.0003755
Ozonoff S, 2010, J AM ACAD CHILD PSY, V49, P256, DOI 10.1016/j.jaac.2009.11.009
Patterson PH, 2009, BEHAV BRAIN RES, V204, P313, DOI 10.1016/j.bbr.2008.12.016
Pelphrey KA, 2011, J CHILD PSYCHOL PSYC, V52, P631, DOI 10.1111/j.1469-7610.2010.02349.x
Phillips B, 2011, CHILD DEV IN PRESS
Prandota J, 2011, RES AUTISM SPECT DIS, V5, P14, DOI 10.1016/j.rasd.2010.03.009
Rajendran G, 2007, DEV REV, V27, P224, DOI 10.1016/j.dr.2007.02.001
Ranganath C, 2010, HIPPOCAMPUS, V20, P1263, DOI 10.1002/hipo.20852
Ring H, 2008, BEHAV BRAIN FUNCT, V4, DOI 10.1186/1744-9081-4-11
Rips LJ, 2006, PSYCHOL REV, V113, P1, DOI 10.1037/0033-295X.113.1.1
Rogers SJ, 2008, J CLIN CHILD ADOLESC, V37, P8, DOI 10.1080/15374410701817808
Saxe R, 2006, CURR OPIN NEUROBIOL, V16, P235, DOI 10.1016/j.conb.2006.03.001
Saygin AP, 2011, SOC COGN AF IN PRESS
Simion F, 2008, P NATL ACAD SCI USA, V105, P809, DOI 10.1073/pnas.0707021105
Simmons DR, 2009, VISION RES, V49, P2705, DOI 10.1016/j.visres.2009.08.005
Simons DJ, 2005, TRENDS COGN SCI, V9, P16, DOI 10.1016/j.tics.2004.11.006
Simons DJ, 2005, CURR DIR PSYCHOL SCI, V14, P44, DOI 10.1111/j.0963-7214.2005.00332.x
Singer T, 2006, NEUROSCI BIOBEHAV R, V30, P855, DOI 10.1016/j.neubiorev.2006.06.011
Sobel DM, 2007, J COGN DEV, V8, P159, DOI 10.1080/15248370701202356
Southgate Victoria, 2009, P331, DOI 10.1007/978-1-59745-479-7_15
Supekar K, 2009, PLOS BIOL, V7, DOI 10.1371/journal.pbio.1000157
Tager-Flusberg H, 2010, NEURAL NETWORKS, V23, P1072, DOI 10.1016/j.neunet.2010.07.008
Tek S, 2008, AUTISM RES, V1, P208, DOI 10.1002/aur.38
Treisman A., 2006, HDB BINDING MEMORY P, P315
Volkmar F, 2005, ANNU REV PSYCHOL, V56, P315, DOI 10.1146/annurev.psych.56.091103.070159
Wass S, 2011, BRAIN COGNITION, V75, P18, DOI 10.1016/j.bandc.2010.10.005
Waytz A, 2010, TRENDS COGN SCI, V14, P383, DOI 10.1016/j.tics.2010.05.006
Weigelt S, 2012, NEUROSCI BIOBEHAV R, V36, P1060, DOI 10.1016/j.neubiorev.2011.12.008
Weismer SE, 2010, J AUTISM DEV DISORD, V40, P1259, DOI 10.1007/s10803-010-0983-1
Weng SJ, 2010, BRAIN RES, V1313, P202, DOI 10.1016/j.brainres.2009.11.057
Williams JHG, 2001, NEUROSCI BIOBEHAV R, V25, P287, DOI 10.1016/S0149-7634(01)00014-8
Zimmer HD, 2010, NEUROSCI BIOBEHAV R, V34, P1066, DOI 10.1016/j.neubiorev.2010.01.014
NR 100
TC 3
Z9 3
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0306-9877
J9 MED HYPOTHESES
JI Med. Hypotheses
PD SEP
PY 2012
VL 79
IS 3
BP 344
EP 351
DI 10.1016/j.mehy.2012.05.032
PG 8
WC Medicine, Research & Experimental
SC Research & Experimental Medicine
GA 998UD
UT WOS:000308265000018
PM 22703905
ER
PT J
AU Bergen, SE
O'Dushlaine, CT
Ripke, S
Lee, PH
Ruderfer, DM
Akterin, S
Moran, JL
Chambert, KD
Handsaker, RE
Backlund, L
Osby, U
McCarroll, S
Landen, M
Scolnick, EM
Magnusson, PKE
Lichtenstein, P
Hultman, CM
Purcell, SM
Sklar, P
Sullivan, PF
AF Bergen, S. E.
O'Dushlaine, C. T.
Ripke, S.
Lee, P. H.
Ruderfer, D. M.
Akterin, S.
Moran, J. L.
Chambert, K. D.
Handsaker, R. E.
Backlund, L.
Osby, U.
McCarroll, S.
Landen, M.
Scolnick, E. M.
Magnusson, P. K. E.
Lichtenstein, P.
Hultman, C. M.
Purcell, S. M.
Sklar, P.
Sullivan, P. F.
TI Genome-wide association study in a Swedish population yields support for
greater CNV and MHC involvement in schizophrenia compared with bipolar
disorder
SO MOLECULAR PSYCHIATRY
LA English
DT Article
DE schizophrenia; bipolar disorder; genetic; genome-wide association; major
histocompatibility complex; copy number variation
ID COMMON VARIANTS; COPY NUMBER; CONFERRING RISK; INCREASE RISK; 16P11.2;
DELETIONS; AUTISM; GENES; REARRANGEMENTS; MICRODELETION
AB Schizophrenia (SCZ) and bipolar disorder (BD) are highly heritable psychiatric disorders with overlapping susceptibility loci and symptomatology. We conducted a genome-wide association study (GWAS) of these disorders in a large Swedish sample. We report a new and independent case-control analysis of 1507 SCZ cases, 836 BD cases and 2093 controls. No single-nucleotide polymorphisms (SNPs) achieved significance in these new samples; however, combining new and previously reported SCZ samples (2111 SCZ and 2535 controls) revealed a genome-wide significant association in the major histocompatibility complex (MHC) region (rs886424, P = 4.54 x 10(-8)). Imputation using multiple reference panels and meta-analysis with the Psychiatric Genomics Consortium SCZ results underscored the broad, significant association in the MHC region in the full SCZ sample. We evaluated the role of copy number variants (CNVs) in these subjects. As in prior reports, deletions were enriched in SCZ, but not BD cases compared with controls. Singleton deletions were more frequent in both case groups compared with controls (SCZ: P = 0.003, BD: P = 0.013), whereas the largest CNVs (>500 kb) were significantly enriched only in SCZ cases (P = 0.0035). Two CNVs with previously reported SCZ associations were also overrepresented in this SCZ sample: 16p11.2 duplications (P = 0.0035) and 22q11 deletions (P = 0.03). These results reinforce prior reports of significant MHC and CNV associations in SCZ, but not BD.
C1 [Bergen, S. E.; O'Dushlaine, C. T.; Lee, P. H.; Ruderfer, D. M.; Purcell, S. M.; Sklar, P.] Massachusetts Gen Hosp, Psychiat & Neurodev Genet Unit, Boston, MA 02114 USA.
[Bergen, S. E.; O'Dushlaine, C. T.; Ripke, S.; Lee, P. H.; Ruderfer, D. M.; Moran, J. L.; Chambert, K. D.; Handsaker, R. E.; McCarroll, S.; Scolnick, E. M.; Purcell, S. M.; Sklar, P.] Broad Inst Harvard & MIT, Stanley Ctr Psychiat Res, Cambridge, MA USA.
[O'Dushlaine, C. T.; Ripke, S.; Lee, P. H.; Ruderfer, D. M.; Purcell, S. M.] Massachusetts Gen Hosp, Analyt & Translat Genet Unit, Boston, MA 02114 USA.
[Akterin, S.; Landen, M.; Magnusson, P. K. E.; Lichtenstein, P.; Hultman, C. M.] Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden.
[Handsaker, R. E.; McCarroll, S.] Harvard Univ, Sch Med, Dept Genet, Boston, MA USA.
[Backlund, L.; Osby, U.] Karolinska Inst, Dept Mol Med & Surg, Stockholm, Sweden.
[Landen, M.] Univ Gothenburg, Inst Neurosci & Physiol, Gothenburg, Sweden.
[Purcell, S. M.; Sklar, P.] Mt Sinai Sch Med, Dept Psychiat, Div Psychiat Genom, New York, NY USA.
[Sullivan, P. F.] Univ N Carolina, Dept Genet, Chapel Hill, NC USA.
[Sullivan, P. F.] Univ N Carolina, Dept Psychiat, Chapel Hill, NC USA.
[Sullivan, P. F.] Univ N Carolina, Dept Epidemiol, Chapel Hill, NC USA.
RP Bergen, SE (reprint author), Broad Inst, 7 Cambridge Ctr,6055H, Cambridge, MA 02142 USA.
EM sbergen@gmail.com
RI Bergen, Sarah/I-8313-2012
FU Stanley Center for Psychiatric Research; Stanley Medical Research
Institute; NIMH [MH077139]; Karolinska Institutet, Karolinska University
Hospital; Swedish Research Council; Swedish County Council; Soderstrom
Konigska Foundation
FX We are deeply grateful for the participation of all subjects
contributing to this research, and to the collection team that worked to
recruit them: Emma Flordal-Thelander, Ann-Britt Holmgren, Marie Hallin,
Marie Lundin, Ann-Kristin Sundberg, Christina Pettersson, Radja
Satgunanthan-Dawoud, Sonja Hassellund, Malin Radstrom, Birgitta
Ohlander, Leila Nyren, Isabelle Kizling, Louise Frisen, Inger Rohmer,
Catharina Lavebratt, Malin Karn, Martina Wennberg and Agneta
Carsward-Kjellin. We would also like to thank Professor Martin Schalling
for facilitating collection of many subjects with BD. Funding support
was provided by the Stanley Center for Psychiatric Research, Broad
Institute from a grant from Stanley Medical Research Institute, NIMH
MH077139 (PFS), the Karolinska Institutet, Karolinska University
Hospital, the Swedish Research Council, ALF grant from Swedish County
Council and Soderstrom Konigska Foundation.
CR ANGERMEYER MC, 1988, EUR ARCH PSY CLIN N, V237, P351, DOI 10.1007/BF00380979
Association AP, 1994, DIAGN STAT MAN MENT
Baum AE, 2008, MOL PSYCHIATR, V13, P197, DOI 10.1038/sj.mp.4002012
Browning SR, 2007, AM J HUM GENET, V81, P1084, DOI 10.1086/521987
Cichon S, 2011, AM J HUM GENET, V88, P372, DOI 10.1016/j.ajhg.2011.01.017
Collins PY, 2011, NATURE, V475, P27, DOI 10.1038/475027a
Craddock N, 2010, BRIT J PSYCHIAT, V196, P92, DOI 10.1192/bjp.bp.109.073429
Dalman C, 2002, SOC PSYCH PSYCH EPID, V37, P527, DOI 10.1007/s00127-002-0582-3
Ekholm B, 2005, NORD J PSYCHIAT, V59, P457, DOI 10.1080/08039480500360906
Ferreira MAR, 2008, NAT GENET, V40, P1056, DOI 10.1038/ng.209
First M. B., 1996, STRUCTURED CLIN INTE
Grozeva D, 2010, ARCH GEN PSYCHIAT, V67, P318, DOI 10.1001/archgenpsychiatry.2010.25
Guilmatre A, 2009, ARCH GEN PSYCHIAT, V66, P947, DOI 10.1001/archgenpsychiatry.2009.80
Handsaker RE, 2011, NAT GENET, V43, P269, DOI 10.1038/ng.768
Altshuler DM, 2010, NATURE, V467, P52, DOI 10.1038/nature09298
Stone JL, 2008, NATURE, V455, P237, DOI 10.1038/nature07239
Ivleva EI, 2010, NEUROSCI BIOBEHAV R, V34, P897, DOI 10.1016/j.neubiorev.2009.11.022
Korn JM, 2008, NAT GENET, V40, P1253, DOI 10.1038/ng.237
Kristjansson E, 1987, NORD PSYKIATR TIDSSK, V41, P229, DOI DOI 10.3109/08039488709103182
Lee KW, 2012, NEUROSCI BIOBEHAV R, V36, P556, DOI 10.1016/j.neubiorev.2011.09.001
Lee PH, 2012, BIOINFORMATICS
Levinson DF, 2011, AM J PSYCHIAT, V168, P302, DOI 10.1176/appi.ajp.2010.10060876
Lichtenstein P, 2009, LANCET, V373, P234, DOI 10.1016/S0140-6736(09)60072-6
McCarthy SE, 2009, NAT GENET, V41, P1223, DOI 10.1038/ng.474
McMichael AJ, 2010, SCIENCE, V330, P1488, DOI 10.1126/science.1200035
McQuillin A, 2011, EUR J HUM GENET, V19, P588, DOI 10.1038/ejhg.2010.221
Mefford HC, 2010, PLOS GENET, V6, DOI 10.1371/journal.pgen.1000962
Moreno-De-Luca D, 2010, AM J HUM GENET, V87, P618, DOI 10.1016/j.ajhg.2010.10.004
Moskvina V, 2011, GENET EPIDEMIOL, V35, P861, DOI 10.1002/gepi.20636
O'Dushlaine C, 2011, MOL PSYCHIATR, V16, P286, DOI 10.1038/mp.2010.7
Pe'er I, 2008, GENET EPIDEMIOL, V32, P381, DOI 10.1002/gepi.20303
Perlis RH, 2004, BIOL PSYCHIAT, V55, P875, DOI 10.1016/j.biopsych.2004.01.022
Purcell S, 2007, AM J HUM GENET, V81, P559, DOI 10.1086/519795
Purcell SM, 2009, NATURE, V460, P748, DOI 10.1038/nature08185
Redon R, 2006, NATURE, V444, P444, DOI 10.1038/nature05329
Ripke S, 2011, NAT GENET, V43, P969, DOI 10.1038/ng.940
Ryden E, 2009, ACTA PSYCHIAT SCAND, V120, P239, DOI 10.1111/j.1600-0447.2009.01399.x
Saha S, 2005, PLOS MED, V2, P413, DOI 10.1371/journal.pmed.0020141
Sampson MG, 2010, AM J MED GENET A, V152A, P2618, DOI 10.1002/ajmg.a.33628
Schaaf CP, 2011, EUR J HUM GENET, V19, P152, DOI 10.1038/ejhg.2010.168
Sebat J, 2009, TRENDS GENET, V25, P528, DOI 10.1016/j.tig.2009.10.004
Sellgren C, 2011, ACTA PSYCHIAT SCAND, V124, P447, DOI 10.1111/j.1600-0447.2011.01747.x
Shi JX, 2009, NATURE, V460, P753, DOI 10.1038/nature08192
Shinawi M, 2010, J MED GENET, V47, P332, DOI 10.1136/jmg.2009.073015
Sklar P, 2011, NAT GENET, V43, P977, DOI 10.1038/ng.943
Smith EN, 2009, MOL PSYCHIATR, V14, P755, DOI 10.1038/mp.2009.43
Smoller JW, 2003, AM J MED GENET C, V123C, P48, DOI 10.1002/ajmg.c.20013
Stefansson H, 2009, NATURE, V460, P744, DOI 10.1038/nature08186
Steinberg S, 2011, HUM MOL GENET, V20, P4076, DOI 10.1093/hmg/ddr325
Walsh T, 2008, SCIENCE, V320, P539, DOI 10.1126/science.1155174
Weiss LA, 2008, NEW ENGL J MED, V358, P667, DOI 10.1056/NEJMoa075974
Zhang D, 2009, MOL PSYCHIATR, V14, P376, DOI 10.1038/mp.2008.144
NR 52
TC 58
Z9 58
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1359-4184
J9 MOL PSYCHIATR
JI Mol. Psychiatr.
PD SEP
PY 2012
VL 17
IS 9
BP 880
EP 886
DI 10.1038/mp.2012.73
PG 7
WC Biochemistry & Molecular Biology; Neurosciences; Psychiatry
SC Biochemistry & Molecular Biology; Neurosciences & Neurology; Psychiatry
GA 996DI
UT WOS:000308063900005
PM 22688191
ER
PT J
AU Ayalew, M
Le-Niculescu, H
Levey, DF
Jain, N
Changala, B
Patel, SD
Winiger, E
Breier, A
Shekhar, A
Amdur, R
Koller, D
Nurnberger, JI
Corvin, A
Geyer, M
Tsuang, MT
Salomon, D
Schork, NJ
Fanous, AH
O'Donovan, MC
Niculescu, AB
AF Ayalew, M.
Le-Niculescu, H.
Levey, D. F.
Jain, N.
Changala, B.
Patel, S. D.
Winiger, E.
Breier, A.
Shekhar, A.
Amdur, R.
Koller, D.
Nurnberger, J. I.
Corvin, A.
Geyer, M.
Tsuang, M. T.
Salomon, D.
Schork, N. J.
Fanous, A. H.
O'Donovan, M. C.
Niculescu, A. B.
TI Convergent functional genomics of schizophrenia: from comprehensive
understanding to genetic risk prediction
SO MOLECULAR PSYCHIATRY
LA English
DT Article
DE biomarkers; convergent functional genomics; genetic risk prediction;
pathways; schizophrenia
ID DORSOLATERAL PREFRONTAL CORTEX; MESSENGER-RNA EXPRESSION; CAUSES
DIFFERENTIAL EXPRESSION; CATECHOL-O-METHYLTRANSFERASE; ANTERIOR
CINGULATE CORTEX; FAMILY-BASED ASSOCIATION; SUPERIOR TEMPORAL GYRUS;
22Q11 DELETION SYNDROME; MAJOR MENTAL ILLNESSES; CASE-CONTROL SAMPLES
AB We have used a translational convergent functional genomics (CFG) approach to identify and prioritize genes involved in schizophrenia, by gene-level integration of genome-wide association study data with other genetic and gene expression studies in humans and animal models. Using this polyevidence scoring and pathway analyses, we identify top genes (DISC1, TCF4, MBP, MOBP, NCAM1, NRCAM, NDUFV2, RAB18, as well as ADCYAP1, BDNF, CNR1, COMT, DRD2, DTNBP1, GAD1, GRIA1, GRIN2B, HTR2A, NRG1, RELN, SNAP-25, TNIK), brain development, myelination, cell adhesion, glutamate receptor signaling, G-protein-coupled receptor signaling and cAMP-mediated signaling as key to pathophysiology and as targets for therapeutic intervention. Overall, the data are consistent with a model of disrupted connectivity in schizophrenia, resulting from the effects of neurodevelopmental environmental stress on a background of genetic vulnerability. In addition, we show how the top candidate genes identified by CFG can be used to generate a genetic risk prediction score (GRPS) to aid schizophrenia diagnostics, with predictive ability in independent cohorts. The GRPS also differentiates classic age of onset schizophrenia from early onset and late-onset disease. We also show, in three independent cohorts, two European American and one African American, increasing overlap, reproducibility and consistency of findings from single-nucleotide polymorphisms to genes, then genes prioritized by CFG, and ultimately at the level of biological pathways and mechanisms. Finally, we compared our top candidate genes for schizophrenia from this analysis with top candidate genes for bipolar disorder and anxiety disorders from previous CFG analyses conducted by us, as well as findings from the fields of autism and Alzheimer. Overall, our work maps the genomic and biological landscape for schizophrenia, providing leads towards a better understanding of illness, diagnostics and therapeutics. It also reveals the significant genetic overlap with other major psychiatric disorder domains, suggesting the need for improved nosology.
C1 [Ayalew, M.; Le-Niculescu, H.; Levey, D. F.; Jain, N.; Changala, B.; Patel, S. D.; Winiger, E.; Breier, A.; Shekhar, A.; Nurnberger, J. I.; Niculescu, A. B.] Indiana Univ Sch Med, Dept Psychiat, Indianapolis, IN 46202 USA.
[Ayalew, M.; Niculescu, A. B.] Indianapolis VA Med Ctr, Indianapolis, IN 46202 USA.
[Amdur, R.; Fanous, A. H.] Washington DC VA Med Ctr, Washington, DC USA.
[Koller, D.] Indiana Univ Sch Med, Dept Med & Mol Genet, Indianapolis, IN 46202 USA.
[Corvin, A.] Trinity Coll Dublin, Dept Psychiat, Dublin, Ireland.
[Geyer, M.; Tsuang, M. T.] Univ Calif San Diego, Dept Psychiat, La Jolla, CA 92093 USA.
[Salomon, D.; Schork, N. J.] Scripps Res Inst, Dept Mol & Expt Med, La Jolla, CA 92037 USA.
[O'Donovan, M. C.] Cardiff Univ, Dept Psychol Med, Cardiff, S Glam, Wales.
RP Niculescu, AB (reprint author), Indiana Univ Sch Med, Dept Psychiat, 791 Union Dr, Indianapolis, IN 46202 USA.
EM anicules@iupui.edu
RI Niculescu, Alexander/A-3328-2012
FU NIH Directors' New Innovator Award [1DP2OD007363]; VA Merit Award
[1I01CX000139-01]
FX This work is, in essence, a field-wide collaboration. We would like to
acknowledge our debt of gratitude for the efforts and results of the
many other groups, cited in our paper, who have conducted and published
empirical studies (human and animal model, genetic and gene expression)
in schizophrenia. With their arduous and careful work, a convergent
approach such as ours is possible. We would particularly like to thank
the ISC and GAIN consortia. We would also like to thank the subjects who
participated in these studies, their families and their caregivers.
Without their contribution, such work to advance the understanding of
mental illness would not be possible. Finally, we would like to
acknowledge Elyn Saks for her insightful memoir, which inspired the
Yeats quote at the beginning of the paper. This work was supported by an
NIH Directors' New Innovator Award (1DP2OD007363) and a VA Merit Award
(1I01CX000139-01) to ABN.
CR Abdolmaleky HM, 2006, HUM MOL GENET, V15, P3132, DOI 10.1093/hmg/ddl253
Akbarian S, 2006, BRAIN RES REV, V52, P293, DOI 10.1016/j.brainresrev.2006.04.001
ALKELAI A, 2011, INT J NEUROPSYCHOPH, V20, P1
Allen NC, 2008, NAT GENET, V40, P827, DOI 10.1038/ng.171
Arion D, 2007, BIOL PSYCHIAT, V62, P711, DOI 10.1016/j.biopsych.2006.12.021
Athanasiu L, 2010, J PSYCHIATR RES, V44, P748, DOI 10.1016/j.jpsychires.2010.02.002
Atz ME, 2007, PSYCHIAT GENET, V17, P55, DOI 10.1097/YPG.0b013e328012d850
Auerbach BD, 2011, NATURE, V480, P63, DOI 10.1038/nature10658
Ayhan Y, 2011, MOL PSYCHIATR, V16, P293, DOI 10.1038/mp.2009.144
Babovic D, 2008, NEUROSCIENCE, V155, P1021, DOI 10.1016/j.neuroscience.2008.07.006
Ballmaier M, 2002, EUR J NEUROSCI, V15, P1197, DOI 10.1046/j.1460-9568.2002.01952.x
Barbier E, 2007, NEUROPSYCHOPHARMACOL, V32, P1774, DOI 10.1038/sj.npp.1301301
Barley K, 2009, SCHIZOPHR RES, V112, P54, DOI 10.1016/j.schres.2009.04.019
Baruch K, 2009, INT J NEUROPSYCHOPH, V12, P885, DOI 10.1017/S1461145708009887
Benes FM, 2008, P NATL ACAD SCI USA, V105, P20935, DOI 10.1073/pnas.0810153105
Beneyto M, 2008, NEUROPSYCHOPHARMACOL, V33, P2175, DOI 10.1038/sj.npp.1301604
Ben-Shachar D, 2007, PLOS ONE, V2, DOI 10.1371/journal.pone.0000817
Bergen SE, 2009, SCHIZOPHR RES, V109, P94, DOI 10.1016/j.schres.2009.02.009
Bertsch B, 2005, METHODS, V37, P274, DOI 10.1016/j.ymeth.2005.03.012
Bord L, 2006, NEUROSCI RES, V56, P286, DOI 10.1016/j.neures.2006.07.010
Bowden NA, 2008, BMC GENOMICS, V9, DOI 10.1186/1471-2164-9-199
Bowden NA, 2006, SCHIZOPHR RES, V82, P175, DOI 10.1016/j.schres.2005.11.012
Bowden NA, 2007, SCHIZOPHR RES, V89, P165, DOI 10.1016/j.schres.2006.09.003
Brandon NJ, 2011, NAT REV NEUROSCI, V12, P707, DOI 10.1038/nrn3120
Brennand KJ, 2011, NATURE, V473, P221, DOI 10.1038/nature09915
Brzozka MM, 2010, BIOL PSYCHIAT, V68, P33, DOI 10.1016/j.biopsych.2010.03.015
Buckley PF, 2009, SCHIZOPHRENIA BULL, V35, P383, DOI 10.1093/schbul/sbn135
Bullock WM, 2008, AM J PSYCHIAT, V165, P1594, DOI 10.1176/appi.ajp.2008.07121845
Callicott JH, 2005, P NATL ACAD SCI USA, V102, P8627, DOI 10.1073/pnas.0500515102
Carless MA, 2011, MOL PSYCHIATR, V16, P1096, DOI 10.1038/mp.2011.37
Carroll LS, 2010, MOL PSYCHIATR, V15, P1101, DOI 10.1038/mp.2009.96
Chagnon YC, 2008, SCHIZOPHR RES, V100, P281, DOI 10.1016/j.schres.2007.12.471
Chan MK, 2011, MOL PSYCHIATR, V16, P1189, DOI 10.1038/mp.2010.100
Chao HM, 2008, AM J MED GENET B, V147B, P505, DOI 10.1002/ajmg.b.30619
Charych EI, 2010, J NEUROSCI, V30, P9027, DOI 10.1523/JNEUROSCI.1635-10.2010
Chen ML, 2005, NEUROPSYCHOPHARMACOL, V30, P268, DOI 10.1038/sj.npp.1300612
Chen Q, 2004, AM J HUM GENET, V75, P873, DOI 10.1086/425588
Chen Q, 2008, SCHIZOPHR RES, V106, P200, DOI 10.1016/j.schres.2008.08.006
Chen XW, 2008, J CELL BIOL, V181, P791, DOI 10.1083/jcb.200711021
Chen YJJ, 2008, J NEUROSCI, V28, P6872, DOI 10.1523/JNEUROSCI.1815-08.2008
Chiba S, 2006, J NEURAL TRANSM, V113, P1337, DOI 10.1007/s00702-005-0414-1
Chong VZ, 2002, J NEUROCHEM, V82, P1533, DOI 10.1046/j.1471-4159.2002.01104.x
Cisse M, 2011, NATURE, V469, P47, DOI 10.1038/nature09635
Clamp M, 2007, P NATL ACAD SCI USA, V104, P19428, DOI 10.1073/pnas.0709013104
Clapcote SJ, 2007, NEURON, V54, P387, DOI 10.1016/j.neuron.2007.04.015
Clark D, 2006, MOL PSYCHIATR, V11, P459, DOI 10.1038/sj.mp.4001806
Colantuoni C, 2011, NATURE, V478, P519, DOI 10.1038/nature10524
Colantuoni C, 2008, BRAIN STRUCT FUNCT, V213, P255, DOI 10.1007/s00429-008-0181-5
Costa E, 2001, NEUROBIOL DIS, V8, P723, DOI 10.1006/nbdi.2001.0436
Craddock N, 2010, BRIT J PSYCHIAT, V196, P92, DOI 10.1192/bjp.bp.109.073429
Davis KL, 2003, LANCET, V362, P758, DOI 10.1016/S0140-6736(03)14297-3
Dean B, 2004, LIFE SCI, V74, P3115, DOI 10.1016/j.lfs.2003.11.004
Decoster J, 2011, AM J MED GENET B, V156B, P363, DOI 10.1002/ajmg.b.31174
Degnan JH, 2008, GENOMICS, V92, P129, DOI 10.1016/j.ygeno.2008.05.012
Deng XD, 2004, BMC PSYCHIATRY, V4, DOI 10.1186/1471-244X-4-21
Devon RS, 2001, MOL PSYCHIATR, V6, P311, DOI 10.1038/sj.mp.4000848
Dlaboga D, 2008, NEUROPHARMACOLOGY, V54, P745, DOI 10.1016/j.neuropharm.2007.12.002
Dracheva S, 2005, J NEUROSCI RES, V79, P868, DOI 10.1002/jnr.20423
Duan X, 2007, CELL, V130, P1146, DOI 10.1016/j.cell.2007.07.010
Dyck BA, 2007, SCHIZOPHR RES, V97, P292, DOI 10.1016/j.schres.2007.08.026
Dyck BA, 2009, SYNAPSE, V63, P662, DOI 10.1002/syn.20643
Eastwood SL, 2005, SCHIZOPHR RES, V73, P159, DOI 10.1016/j.schres.05.010
Eggan SM, 2008, ARCH GEN PSYCHIAT, V65, P772, DOI 10.1001/archpsyc.65.7.772
Ekelund J, 2000, HUM MOL GENET, V9, P1049, DOI 10.1093/hmg/9.7.1049
Erdely HA, 2006, SYNAPSE, V59, P472, DOI 10.1002/syn.20265
Fallin MD, 2005, AM J HUM GENET, V77, P918, DOI 10.1086/497703
Fanous AH, 2010, AM J MED GENET B, V153B, P663, DOI 10.1002/ajmg.b.31037
Faraone SV, 1998, AM J MED GENET, V81, P290, DOI 10.1002/(SICI)1096-8628(19980710)81:4<290::AID-AJMG3>3.0.CO;2-Y
Fatemi SH, 2009, SCHIZOPHR RES, V111, P138, DOI 10.1016/j.schres.2009.03.002
Fatemi SH, 2008, SCHIZOPHR RES, V101, P36, DOI 10.1016/j.schres.2008.01.029
Fatemi SH, 2010, SYNAPSE, V64, P550, DOI 10.1002/syn.20762
Fatemi SH, 2005, SYNAPSE, V57, P91, DOI 10.1002/syn.20162
Fatjo-Vilas M, 2011, AM J MED GENET B, V156B, P322, DOI 10.1002/ajmg.b.31166
Feng YQ, 2008, SCHIZOPHR RES, V106, P218, DOI 10.1016/j.schres.2008.07.018
Freedman R, 2001, AM J MED GENET, V105, P794, DOI 10.1002/ajmg.10100
Fukuda Y, 2006, BIOL PSYCHIAT, V60, P1331, DOI 10.1016/j.biopsych.2006.06.024
Gabriel SM, 1997, ARCH GEN PSYCHIAT, V54, P559
Galter D, 2003, NEUROBIOL DIS, V14, P637, DOI 10.1016/j.nbd.2003.09.001
Garbett Krassimira, 2008, Neuropsychopharmacol Hung, V10, P9
Glatt SJ, 2005, P NATL ACAD SCI USA, V102, P15533, DOI 10.1073/pnas.0507666102
Glatt SJ, 2011, AM J MED GENET B, V156B, P869, DOI 10.1002/ajmg.b.31239
Glessner JT, 2010, P NATL ACAD SCI USA, V107, P10584, DOI 10.1073/pnas.1000274107
Gratacos M, 2007, BIOL PSYCHIAT, V61, P911, DOI 10.1016/j.biopsych.2006.08.025
Grayson DR, 2005, P NATL ACAD SCI USA, V102, P9341, DOI 10.1073/pnas.0503736102
Green EK, 2011, AM J MED GENET B, V156B, P490, DOI 10.1002/ajmg.b.31187
Greenwood TA, 2011, AM J PSYCHIAT, V168, P930, DOI 10.1176/appi.ajp.2011.10050723
Grillet N, 2005, MOL CELL BIOL, V25, P4221, DOI 10.1128/MCB.25.10.4221-4228.2005
Grillo RW, 2007, J PSYCHIAT RES, V41, P31, DOI 10.1016/j.jpsychires.2006.01.005
Grottick AJ, 2005, MOL BRAIN RES, V139, P153, DOI 10.1016/j.molbrainres.2005.05.020
Guidotti A, 2000, ARCH GEN PSYCHIAT, V57, P1061, DOI 10.1001/archpsyc.57.11.1061
Guo CM, 2010, J BIOMED BIOTECHNOL, DOI 10.1155/2010/783297
Hahn CG, 2006, NAT MED, V12, P824, DOI 10.1038/nm1418
Hakak Y, 2001, P NATL ACAD SCI USA, V98, P4746, DOI 10.1073/pnas.081071198
Haller J, 2005, BEHAV PHARMACOL, V16, P415, DOI 10.1097/00008877-200509000-00014
Haroutunian V, 2007, INT J NEUROPSYCHOPH, V10, P499, DOI 10.1017/S1461145706007449
Harris LW, 2009, BMC MED GENOMICS, V2, DOI 10.1186/1755-8794-2-28
Hashimoto R, 2004, MOL PSYCHIATR, V9, P299, DOI 10.1038/sj.mp.4001434
Hashimoto R, 2007, MOL PSYCHIATR, V12, P1026, DOI 10.1038/sj.mp.4001982
Hashimoto T, 2003, J NEUROSCI, V23, P6315
Hashimoto T, 2008, MOL PSYCHIATR, V13, P147, DOI 10.1038/sj.mp.4002011
Hashimoto T, 2008, AM J PSYCHIAT, V165, P479, DOI 10.1176/appi.ajp.2007.07081223
Hattori S, 2008, BIOCHEM BIOPH RES CO, V373, P298, DOI 10.1016/j.bbrc.2008.06.016
Hattori T, 2010, Mol Psychiatry, V15, P798, DOI 10.1038/mp.2010.60
Hattori T, 2010, MOL PSYCHIATR, V15, P98
Heckers S, 2002, ARCH GEN PSYCHIAT, V59, P521, DOI 10.1001/archpsyc.59.6.521
Hemby SE, 2002, ARCH GEN PSYCHIAT, V59, P631, DOI 10.1001/archpsyc.59.7.631
Hennah W, 2009, MOL PSYCHIATR, V14, P865, DOI 10.1038/mp.2008.22
Hikida T, 2007, P NATL ACAD SCI USA, V104, P14501, DOI 10.1073/pnas.0704774104
Hill JJ, 2006, MOL PSYCHIATR, V11, P557, DOI 10.1038/sj.mp.4001792
Huang J, 2010, AM J PSYCHIAT, V167, P1254, DOI 10.1176/appi.ajp.2010.09091335
Huotari M, 2004, PSYCHOPHARMACOLOGY, V172, P1, DOI 10.1007/s00213-003-1627-3
Ibrahim HM, 2000, AM J PSYCHIAT, V157, P1811, DOI 10.1176/appi.ajp.157.11.1811
Ikeda M, 2011, BIOL PSYCHIAT, V69, P472, DOI 10.1016/j.biopsych.2010.07.010
Impagnatiello F, 1998, P NATL ACAD SCI USA, V95, P15718, DOI 10.1073/pnas.95.26.15718
Ishiguro H, 2010, SCHIZOPHRENIA BULL, V36, P756, DOI 10.1093/schbul/sbn160
Ishizuka K, 2011, NATURE, V473, P92, DOI 10.1038/nature09859
Jablensky A, 2011, GENES BRAIN BEHAV, V10, P410, DOI 10.1111/j.1601-183X.2011.00679.x
Javitt DC, 2011, SCI TRANSL MED, V3, DOI 10.1126/scitranslmed.3002804
Jeans AF, 2007, P NATL ACAD SCI USA, V104, P2431, DOI 10.1073/pnas.0610222104
Ji BH, 2009, J PROTEOME RES, V8, P3633, DOI 10.1021/pr800876z
Jia P, 2010, MOL PSYCHIATR, V15, P453, DOI 10.1038/mp.2009.93
Jurata LW, 2006, SCHIZOPHR RES, V88, P251, DOI 10.1016/j.schres.2006.07.017
Kahler AK, 2010, AM J MED GENET B, V153B, P86, DOI 10.1002/ajmg.b.30958
Kahler AK, 2008, AM J MED GENET B, V147B, P1089, DOI 10.1002/ajmg.b.30726
Kaiser S, 2004, NEUROBIOL DIS, V16, P220, DOI 10.1016/j.nbd.2004.01.011
Kang EC, 2011, NEURON, V72, P559, DOI 10.1016/j.neuron.2011.09.032
Karson CN, 1999, MOL PSYCHIATR, V4, P39, DOI 10.1038/sj.mp.4000459
Katsel P, 2005, SCHIZOPHR RES, V79, P157, DOI 10.1016/j.schres.2005.06.007
Chu TT, 2009, J HUM GENET, V54, P665, DOI 10.1038/jhg.2009.93
Kinney GG, 2003, J PHARMACOL EXP THER, V306, P116, DOI 10.1124/jpet.103.048702
Kirov G, 2004, BIOL PSYCHIAT, V55, P971, DOI 10.1016/j.biopsych.2004.01.025
Kirov G, 2012, MOL PSYCHIATR, V17, P142, DOI 10.1038/mp.2011.154
Knable MB, 2004, MOL PSYCHIATR, V9, P609, DOI 10.1038/sj.mp.4001471
Kochlamazashvili G, 2010, J NEUROSCI, V30, P4171, DOI 10.1523/JNEUROSCI.5806-09.2010
Koga M, 2010, PSYCHIAT GENET, V20, P123, DOI 10.1097/YPG.0b013e32833a1f52
Koike H, 2006, P NATL ACAD SCI USA, V103, P3693, DOI 10.1073/pnas.0511189103
Konradi C, 2012, NEUROBIOL DIS, V45, P37, DOI 10.1016/j.nbd.2011.01.025
Kurian SM, 2011, MOL PSYCHIATR, V16, P37, DOI 10.1038/mp.2009.117
Kurotaki N, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0020589
Kushima I., 2010, SCHIZOPHR B
Kuzman MR, 2009, J PSYCHIATR RES, V43, P1073, DOI 10.1016/j.jpsychires.2009.03.005
Kvajo M, 2008, P NATL ACAD SCI USA, V105, P7076, DOI 10.1073/pnas.0802615105
Law AJ, 2006, P NATL ACAD SCI USA, V103, P6747, DOI 10.1073/pnas.0602002103
Law AJ, 2004, NEUROSCIENCE, V127, P125, DOI 10.1016/j.neuroscience.2004.04.026
Lee Hee Jae, 2005, Behav Brain Funct, V1, P15, DOI 10.1186/1744-9081-1-15
Le-Niculescu H, 2009, MOL PSYCHIATR, V14, P156, DOI 10.1038/mp.2008.11
Le-Niculescu H, 2008, AM J MED GENET B, V147B, P134, DOI 10.1002/ajmg.b.30707
Le-Niculescu H, 2007, AM J MED GENET B, V144B, P129, DOI 10.1002/ajmg.b.30481
Le-Niculescu H, 2011, TRANSL PSYCHIAT, V1, DOI 10.1038/tp.2011.9
Le-Niculescu H, 2010, CURR OPIN PHARMACOL, V10, P594, DOI 10.1016/j.coph.2010.08.008
Le-Niculescu H, 2011, TRANSL PSYCHIAT, V1, DOI 10.1038/tp.2011.1
Lennertz L, 2011, NEUROPSYCHOBIOLOGY, V63, P131, DOI 10.1159/000317844
Leon CA, 2011, PSYCHIAT GENET, V21, P114, DOI 10.1097/YPG.0b013e328341a334
Levinson DF, 2011, AM J PSYCHIAT, V168, P302, DOI 10.1176/appi.ajp.2010.10060876
Lewis CM, 2003, AM J HUM GENET, V73, P34, DOI 10.1086/376549
Li C, 2006, NEUROSCI LETT, V407, P151, DOI 10.1016/j.neulet.2006.08.025
Li T, 2010, BIOL PSYCHIAT, V68, P671, DOI 10.1016/j.biopsych.2010.06.014
Lipska BK, 2006, HUM MOL GENET, V15, P2804, DOI 10.1093/hmg/ddl222
Liu W, 2010, PHARMACOGENOMICS J
Liu YL, 2006, BIOL PSYCHIAT, V60, P554, DOI 10.1016/j.biopsych.2006.04.024
Lowe XR, 2007, BRAIN RES, V1174, P7, DOI 10.1016/j.brainres.2007.07.039
MacDonald ML, 2005, BIOL PSYCHIAT, V57, P1041, DOI 10.1016/j.biopsych.2005.01.022
Magri C, 2006, AM J MED GENET B, V141B, P287, DOI 10.1002/ajmg.b.30294
Makino C, 2003, AM J MED GENET B, V116B, P17, DOI 10.1002/ajmg.b.10041
Martin MV, 2009, BMC MED GENOMICS, V2, DOI 10.1186/1755-8794-2-62
Marvanova M, 2004, NEUROPSYCHOPHARMACOL, V29, P1070, DOI 10.1038/sj.npp.1300398
Matsuoka T, 2008, SYNAPSE, V62, P1, DOI 10.1002/syn.20455
Matute C, 2005, GLIA, V49, P451, DOI 10.1002/glia.20119
Maziade M, 2005, MOL PSYCHIATR, V10, P486, DOI 10.1038/sj.mp.4001594
McClay JL, 2011, NEUROPSYCHOPHARMACOL, V36, P616, DOI 10.1038/npp.2010.193
McClay JL, 2011, MOL PSYCHIATR, V16, P76, DOI 10.1038/mp.2009.89
McOmish CE, 2008, HIPPOCAMPUS, V18, P824, DOI 10.1002/hipo.20443
Middleton FA, 2005, AM J MED GENET B, V136B, P12, DOI 10.1002/ajmg.b.30171
Millar JK, 2007, J PHYSIOL-LONDON, V584, P401, DOI 10.1113/jphysiol.2007.140210
Miodownik C, 2011, CLIN NEUROPHARMACOL, V34, P155, DOI 10.1097/WNF.0b013e318220d8c6
Mirnics K, 2000, NEURON, V28, P53, DOI 10.1016/S0896-6273(00)00085-4
Mirnics K, 2001, MOL PSYCHIATR, V6, P293, DOI 10.1038/sj.mp.4000866
Mitkus SN, 2008, SCHIZOPHR RES, V98, P129, DOI 10.1016/j.schres.2007.09-032
Moghaddam B, 2012, NEUROPSYCHOPHARMACOL, V37, P4, DOI 10.1038/npp.2011.181
Mondelli V, 2011, J CLIN PSYCHIAT, V72, P1677, DOI 10.4088/JCP.10m06745
Moy SS, 2009, BEHAV BRAIN RES, V205, P123, DOI 10.1016/j.bbr.2009.06.021
Mozhui XW, 2011, TRANSL PSYCHIAT, V1, pe38
Mudge J, 2008, PLOS ONE, V3, DOI 10.1371/journal.pone.0003625
Murray RM, 2007, NAT REV NEUROSCI, V8, P885, DOI 10.1038/nrn2253
Nakata K, 2009, P NATL ACAD SCI USA, V106, P15873, DOI 10.1073/pnas.0903413106
Newsom RJ, 2012, NEUROSCIENCE, V204, P64, DOI 10.1016/j.neuroscience.2011.11.043
Niculescu AB, 2006, PSYCHIAT GENET, V16, P241, DOI 10.1097/01.ypg.0000242195.74268.f9
Niculescu AB, 2010, NEUROPSYCHOPHARMACOL, V35, P355, DOI 10.1038/npp.2009.107
Niculescu AB, 2010, J AFFECT DISORDERS, V123, P1, DOI 10.1016/j.jad.2009.06.022
Niculescu AB, 2000, PHYSIOL GENOMICS, V4, P83
Niculescu AB, 2006, AM J MED GENET B, V141B, P653, DOI 10.1002/ajmg.b.30404
O'Donovan MC, 2009, HUM GENET, V126, P3, DOI 10.1007/s00439-009-0703-0
Ogden CA, 2004, MOL PSYCHIATR, V9, P1007, DOI 10.1038/sj.mp.4001547
Olincy A, 2011, TRANSL BIOMED, V2, p[183, ii]
Ortega-Alvaro A, 2011, NEUROPSYCHOPHARMACOL, V36, P1489, DOI 10.1038/npp.2011.34
O'Tuathaigh CMP, 2007, NEUROSCIENCE, V147, P18, DOI 10.1016/j.neuroscience.2007.03.051
Ouchi Y, 2005, MOL BRAIN RES, V140, P142, DOI 10.1016/j.molbrianres.2005.07.011
Ovadia G, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0019955
Pae CU, 2009, NEUROPSYCHOBIOLOGY, V59, P135, DOI 10.1159/000218075
Palo OM, 2007, HUM MOL GENET, V16, P2517, DOI 10.1093/hmg/ddm207
Patel SD, 2010, AM J MED GENET B, V153B, P850, DOI 10.1002/ajmg.b.31087
Paylor R, 2006, P NATL ACAD SCI USA, V103, P7729, DOI 10.1073/pnas.0600206103
Petryshen TL, 2005, MOL PSYCHIATR, V10, P366, DOI 10.1038/sj.mp.4001608
Pickard BS, 2007, PSYCHIAT GENET, V17, P129, DOI 10.1097/YPG.0b013e328014492b
Pillai A, 2008, SCHIZOPHR RES, V100, P325, DOI 10.1016/j.schres.2007.11.030
Pillai A, 2008, PLOS ONE, V3, DOI 10.1371/journal.pone.0001784
Pletnikov MV, 2008, MOL PSYCHIATR, V13, P173, DOI 10.1038/sj.mp.4002079
Pletnikov M V, 2008, Mol Psychiatry, V13, P115, DOI 10.1038/sj.mp.4002144
Polesskaya OO, 2002, J NEUROSCI RES, V67, P812, DOI 10.1002/jnr.10173
Porteous DJ, 2011, TRENDS MOL MED, V17, P699, DOI 10.1016/j.molmed.2011.09.002
Potkin SG, 2009, SCHIZOPHRENIA BULL, V35, P96, DOI 10.1093/schbul/sbn155
Potkin SG, 2010, NEUROIMAGE, V53, P839, DOI 10.1016/j.neuroimage.2010.06.036
Prabakaran S, 2004, MOL PSYCHIATR, V9, P684, DOI 10.1038/sj.mp.4001511
Prasad KM, 2010, SCHIZOPHRENIA BULL, V36, P983, DOI 10.1093/schbul/sbp002
Prasad KMR, 2005, MOL PSYCHIATR, V10, P213, DOI 10.1038/sj.mp.4001562
Purcell SM, 2009, NATURE, V460, P748, DOI 10.1038/nature08185
Quednow BB, 2011, J NEUROSCI, V31, P6684, DOI 10.1523/JNEUROSCI.0526-11.2011
Rasetti R, 2011, ARCH GEN PSYCHIAT, V68, P1207, DOI 10.1001/archgenpsychiatry.2011.103
Rethelyi JM, 2010, AM J MED GENET B, V153B, P792, DOI 10.1002/ajmg.b.31049
Rizos EN, 2011, SCHIZOPHR RES, V129, P201, DOI 10.1016/j.schres.2011.03.011
Rodd ZA, 2007, PHARMACOGENOMICS J, V7, P222, DOI 10.1038/sj.tpj.6500420
Rojas P, 2007, MOL PSYCHIATR, V12, P756, DOI 10.1038/sj.mp.4001993
Roussos P, 2012, ARCH GEN PSYCHIAT, V69, P7, DOI 10.1001/archgenpsychiatry.2011.110
Sagata N, 2010, GENES BRAIN BEHAV, V9, P899, DOI 10.1111/j.1601-183X.2010.00629.x
Saviouk V, 2007, SCHIZOPHR RES, V96, P100, DOI 10.1016/j.schres.2007.07.031
Schumacher J, 2009, HUM MOL GENET, V18, P2719, DOI 10.1093/hmg/ddp204
Schurov IL, 2004, MOL PSYCHIATR, V9, P1100, DOI 10.1038/sj.mp.4001574
Schwab SG, 2003, AM J HUM GENET, V72, P185, DOI 10.1086/345463
Schwarz E, 2011, MOL PSYCHIAT
Shao L, 2008, BIOL PSYCHIAT, V64, P89, DOI 10.1016/j.biopsych.2007.11.010
Shen SB, 2008, J NEUROSCI, V28, P10893, DOI 10.1523/JNEUROSCI.3299-08.2008
Shi JX, 2009, NATURE, V460, P753, DOI 10.1038/nature08192
Shifman S, 2008, PLOS GENET, V4, DOI 10.1371/journal.pgen.0040028
Shifman S, 2002, AM J HUM GENET, V71, P1296, DOI 10.1086/344514
Silver H, 2011, INT J NEUROPSYCHOPH, V14, P573, DOI 10.1017/S1461145710001471
Singh KK, 2010, NEURON, V67, P33, DOI 10.1016/j.neuron.2010.06.002
Singh KK, 2011, NEURON, V72, P545, DOI 10.1016/j.neuron.2011.09.030
Siuciak JA, 2008, PSYCHOPHARMACOLOGY, V197, P115, DOI 10.1007/s00213-007-1014-6
So HC, 2008, AM J MED GENET B, V147B, P77, DOI 10.1002/ajmg.b.30577
Sokolov BP, 1998, J NEUROCHEM, V71, P2454
Sommer JU, 2010, EUR ARCH PSY CLIN N, V260, pS81, DOI 10.1007/s00406-010-0159-1
Stadler F, 2005, J NEUROCHEM, V94, P324, DOI 10.1111/j.1471-4159.2005.03190.x
Stefansson H, 2009, NATURE, V460, P744, DOI 10.1038/nature08186
Stefansson H, 2003, AM J HUM GENET, V72, P83, DOI 10.1086/345442
Stefansson H, 2002, AM J HUM GENET, V71, P877, DOI 10.1086/342734
Steward LJ, 2004, NEUROPHARMACOLOGY, V47, P527, DOI 10.1016/j.neuropharm.2004.04.020
Straub RE, 2002, MOL PSYCHIATR, V7, P542, DOI 10.1038/sj.mp.4001051
Straub RE, 2007, MOL PSYCHIATR, V12, P854, DOI 10.1038/sj.mp.4001988
Suchanek R, 2012, J MOL NEUROSCI, V46, P217, DOI 10.1007/s12031-011-9582-7
Takahashi N, 2011, PROG NEUROBIOL, V93, P13, DOI 10.1016/j.pneurobio.2010.09.004
Takahashi S, 2005, PSYCHIAT RES, V133, P111, DOI 10.1016/j.psychres.2004.12.003
Takahashi Y, 2004, ANN NY ACAD SCI, V1025, P561, DOI 10.1196/annals.1316.069
Takao K, 2008, MOL BRAIN, V1, DOI 10.1186/1756-6606-1-11
Talbot K, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0016886
Talbot K, 2004, J CLIN INVEST, V113, P1353, DOI 10.1172/JCI200420425
Tan HY, 2008, MOL PSYCHIATR, V13, P233, DOI 10.1038/sj.mp.4002145
Thompson PM, 2003, PROG NEURO-PSYCHOPH, V27, P411, DOI 10.1016/S0278-5846(03)00027-7
Tkachev D, 2003, LANCET, V362, P798, DOI 10.1016/S0140-6736(03)14289-4
Tomppo L, 2009, BIOL PSYCHIAT, V65, P1055, DOI 10.1016/j.biopsych.2009.01.014
Torrey EF, 2005, BIOL PSYCHIAT, V57, P252, DOI 10.1016/j.biopsych.2004.10.019
Toyooka K, 2002, ANN NY ACAD SCI, V965, P10
Tregellas JR, 2011, BIOL PSYCHIAT, V69, P7, DOI 10.1016/j.biopsych.2010.07.004
Tsutsumi A, 2011, BEHAV BRAIN FUNCT, V7, DOI 10.1186/1744-9081-7-43
Ujike H, 2002, MOL PSYCHIATR, V7, P515, DOI 10.1038/sj.mp.4001029
Vacic V, 2011, NATURE, V471, P499, DOI 10.1038/nature09884
van Schijndel JE, 2009, J PSYCHIATR RES, V43, P1195, DOI 10.1016/j.jpsychires.2009.04.006
Vawter MP, 2002, MOL PSYCHIATR, V7, P571, DOI 10.1038/sj.mp.4001158
Vawter MP, 2002, SCHIZOPHR RES, V58, P11, DOI 10.1016/S0920-9964(01)00377-2
Veldic M, 2005, P NATL ACAD SCI USA, V102, P2152, DOI 10.1073/pnas.0409665102
Veldic M, 2004, P NATL ACAD SCI USA, V101, P348, DOI 10.1079/pnas.2637013100
Voisey J, 2010, EUR PSYCHIAT, V25, P314, DOI 10.1016/j.eurpsy.2009.11.011
Volk DW, 2010, AM J PSYCHIAT, V167, P1489, DOI 10.1176/appi.ajp.2010.10030318
Walker RM, 2010, NEUROSCI LETT, V478, P9, DOI 10.1016/j.neulet.2010.04.056
Wang L, 2010, J PROTEOME RES, V9, P521, DOI 10.1021/pr900867x
Wang Q, 2011, MOL PSYCHIATR, V16, P1006, DOI 10.1038/mp.2010.87
Washizuka S, 2006, AM J MED GENET B, V141B, P301, DOI 10.1002/ajmg.b.30285
Watanabe A, 2007, PLOS BIOL, V5, P2469, DOI 10.1371/journal.pbio.0050297
Weickert CS, 2008, SCHIZOPHR RES, V98, P105, DOI 10.1016/j.schres.2007.05.041
Weickert CS, 2004, ARCH GEN PSYCHIAT, V61, P544, DOI 10.1001/archpsyc.61.6.544
Weickert CS, 2003, MOL PSYCHIATR, V8, P592, DOI 10.1038/sj.mp.4001308
Weidenhofer J, 2006, MOL CELL NEUROSCI, V31, P243, DOI 10.1016/j.mcn.2005.09.013
Wiedholz LM, 2008, MOL PSYCHIATR, V13, P631, DOI 10.1038/sj.mp.4002056
Williams HJ, 2011, HUM MOL GENET, V20, P387, DOI 10.1093/hmg/ddq471
Williams NM, 2008, HUM MOL GENET, V17, P555, DOI 10.1093/hmg/ddm330
Woo TUW, 2004, ARCH GEN PSYCHIAT, V61, P649, DOI 10.1001/archpsyc.61.7.649
Wood GK, 1998, NEUROREPORT, V9, P461, DOI 10.1097/00001756-199802160-00019
Xi ZR, 2004, NEUROSCI LETT, V372, P200, DOI 10.1016/j.neulet.2004.09.041
Xu B, 2009, P NATL ACAD SCI USA, V106, P16746, DOI 10.1073/pnas.0908584106
Yamauchi Y, 2005, BRAIN RES, V1056, P59, DOI 10.1016/j.brainres.2005.07.015
Zhan L, 2011, NEUROPATH APPL NEURO, V37, P206, DOI 10.1111/j.1365-2990.2010.01128.x
NR 290
TC 109
Z9 111
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1359-4184
J9 MOL PSYCHIATR
JI Mol. Psychiatr.
PD SEP
PY 2012
VL 17
IS 9
BP 887
EP 905
DI 10.1038/mp.2012.37
PG 19
WC Biochemistry & Molecular Biology; Neurosciences; Psychiatry
SC Biochemistry & Molecular Biology; Neurosciences & Neurology; Psychiatry
GA 996DI
UT WOS:000308063900006
PM 22584867
ER
PT J
AU Robinson, SJ
AF Robinson, Sally J.
TI Childhood Epilepsy and Autism Spectrum Disorders: Psychiatric Problems,
Phenotypic Expression, and Anticonvulsants
SO NEUROPSYCHOLOGY REVIEW
LA English
DT Review
DE Pervasive developmental disorder; Asperger syndrome; Antiepileptic;
Depression; Anxiety; ADHD; Cognitive functioning
ID PLACEBO-CONTROLLED TRIAL; ONSET EPILEPSY; DOUBLE-BLIND; DEVELOPMENTAL
DISORDERS; DIVALPROEX SODIUM; ASPERGER-SYNDROME; SPECIAL NEEDS; PROJECT
SNAP; CHILDREN; POPULATION
AB Epilepsy and autism spectrum disorders (ASDs) frequently co-occur during childhood, however, the characteristics of psychiatric or behavioural problems in these children remains largely unknown. This article contributes to these discussions by reporting on the prevalence and presentation of psychiatric or behavioural problems in children with epilepsy and ASDs, as well as on the use of anticonvulsants in these children. The current evidence suggests that children with epilepsy and ASDs may present with a distinct clinical profile, with a greater number of developmental difficulties, and a more severe expression of the ASD phenotype that can not solely be accounted for by level of intellectual functioning. Positive effects of anticonvulsants on behavioural symptoms associated with ASDs were also reported, though pharmacoresistance and a lack of clear treatment guidelines may contribute to an elevated risk of adverse side effects. In relation to clinical presentation and management there is a need for careful consideration of potential interaction effects between disorder specific factors (e.g., age of seizure onset/ASD diagnosis), cognitive characteristics (e.g., intellectual functioning, memory), and psychosocial variables (e.g., coping strategies). Ultimately however, many conclusions are tentative and this review highlights the need for more empirically validated research on children with epilepsy and ASDs.
C1 St Thomas Hosp, Childrens Neurosci Ctr, London SE1 7EH, England.
RP Robinson, SJ (reprint author), St Thomas Hosp, Childrens Neurosci Ctr, Westminster Bridge Rd, London SE1 7EH, England.
EM sally.robinson@gstt.nhs.uk
CR Achenbach T. M., 1991, INTEGRATIVE GUIDE 19
American Psychiatric Association, 2000, DIAGN STAT MAN MENT
Amiet C, 2008, BIOL PSYCHIAT, V64, P577, DOI 10.1016/j.biopsych.2008.04.030
Anagnostou E, 2006, J CLIN PSYCHOPHARM, V26, P444, DOI 10.1097/01.jcp.0000227703.72117.bc
Austin K, 2007, EPILEPSIA, V48, P1639, DOI [DOI 10.1111/J.1528-1167.2007.01154.X, 10.1111/j.1528-1167.2007.01154.x]
Baird G, 2006, LANCET, V368, P210, DOI 10.1016/S0140-6736(06)69041-7
Baron-Cohen S, 2001, J CHILD PSYCHOL PSYC, V42, P241, DOI 10.1017/S0021963001006643
Bellini S, 2006, FOCUS AUTISM OTHER D, V21, P138, DOI DOI 10.1177/10883576060210030201
Bellini S., 2004, FOCUS AUTISM OTHER D, V19, P78, DOI DOI 10.1177/10883576040190020201
Belsito KM, 2001, J AUTISM DEV DISORD, V31, P175, DOI 10.1023/A:1010799115457
Berg AT, 2012, EPILEPSY BEHAV, V23, P193, DOI 10.1016/j.yebeh.2012.01.015
Berg AT, 2011, EPILEPSY BEHAV, V20, P550, DOI 10.1016/j.yebeh.2010.12.038
Boltor PF, 2011, BRIT J PSYCHIAT, V198, P289, DOI 10.1192/bjp.bp.109.076877
Brooks-Kayal A, 2010, BRAIN DEV-JPN, V32, P731, DOI 10.1016/j.braindev.2010.04.010
Caplan R, 2008, EPILEPSIA, V49, P1838, DOI 10.1111/j.1528-1167.2008.01680.x
Charman T, 2011, PSYCHOL MED, V41, P619, DOI 10.1017/S0033291710000991
Childs J A, 1997, J Neurosci Nurs, V29, P244
Clarke DF, 2005, EPILEPSIA, V46, P1970, DOI 10.1111/j.1528-1167.2005.00343.x
Costello EJ, 2003, ARCH GEN PSYCHIAT, V60, P837, DOI 10.1001/archpsyc.60.8.837
Danielsson S, 2005, EPILEPSIA, V46, P918, DOI 10.1111/j.1528-1167.2005.57504.x
Davanzo PA, 1996, J CHILD ADOL PSYCHOP, V6, P273, DOI 10.1089/cap.1996.6.273
Davies S, 2003, DEV MED CHILD NEUROL, V45, P292, DOI 10.1017/S0012162203000550
Depositario-Cabacar DFT, 2010, DEV DISABIL RES REV, V16, P239, DOI 10.1002/ddrr.116
Desai J, 2011, J CHILD NEUROL, V26, P329, DOI 10.1177/0883073810380916
Dritschel B, 2010, AUTISM, V14, P509, DOI 10.1177/1362361310368407
Dunn D. W., 2008, DEV MED CHILD NEUROL, V51, P364, DOI 10.111/j.1469-8749.2008.03172.x
Gaitatzis A, 2004, ACTA NEUROL SCAND, V110, P207, DOI 10.1111/j.1600-0404.2004.00324.x
GILLBERG C, 1991, J AUTISM DEV DISORD, V21, P61, DOI 10.1007/BF02206998
Giovanardi Rossi P, 2000, Brain Dev, V22, P102, DOI 10.1016/S0387-7604(99)00124-2
Hamed SA, 2009, CNS NEUROSCI THER, V15, P134, DOI 10.1111/j.1755-5949.2008.00062.x
Happe F, 2008, NEUROPSYCHOL REV, V18, P287, DOI 10.1007/s11065-008-9076-8
Hardan AY, 2004, J CHILD ADOL PSYCHOP, V14, P426, DOI 10.1089/1044546042389082
Hill EL, 2004, DEV REV, V24, P189, DOI 10.1016/j.dr.2004.01.001
Hilty DM, 1998, J NEUROPSYCH CLIN N, V10, P365
Hollander E, 2001, J CLIN PSYCHIAT, V62, P530
Hollander E, 2006, INT J NEUROPSYCHOPH, V9, P209, DOI 10.1017/S1461145705005791
Jones JE, 2007, DEV MED CHILD NEUROL, V49, P493
Lind SE, 2010, AUTISM, V14, P430, DOI 10.1177/1362361309358700
Mahoney WJ, 1998, J AM ACAD CHILD PSY, V37, P278, DOI 10.1097/00004583-199803000-00012
Mandy W, 2011, AUTISM RES, V4, P121, DOI 10.1002/aur.178
Matson JL, 2010, DEV NEUROREHABIL, V13, P310, DOI 10.3109/17518421003782192
Matsuo M, 2010, BRAIN DEV-JPN, V32, P759, DOI 10.1016/j.braindev.2010.05.005
NASS R, 1990, J CHILD NEUROL, V5, P327
National Institute for Health and Clinical Excellence, 2004, EP DIAGN MAN EP AD C
Newschaffer CJ, 2007, ANNU REV PUBL HEALTH, V28, P235, DOI 10.1146/annurev.publhealth.28.021406.144007
Nomura Y, 2010, BRAIN DEV-JPN, V32, P799, DOI 10.1016/j.braindev.2010.08.001
Park SP, 2008, J CLIN NEUROL, V4, P99, DOI 10.3988/jcn.2008.4.3.99
Pavone P, 2004, NEUROPEDIATRICS, V35, P207, DOI 10.1055/s-2004-821079
PLIOPLYS AV, 1994, ARCH PEDIAT ADOL MED, V148, P220
Polanczyk G, 2007, AM J PSYCHIAT, V164, P942, DOI 10.1176/appi.ajp.164.6.942
Ramsay J. R., 2005, PSYCHOTHERAPY THEORY, V42, P482
Reilly C, 2011, SEIZURE-EUR J EPILEP, V20, P589, DOI 10.1016/j.seizure.2011.06.004
Reilly CJ, 2011, RES DEV DISABIL, V32, P883, DOI 10.1016/j.ridd.2011.01.019
Rezaei V, 2010, PROG NEURO-PSYCHOPH, V34, P1269, DOI 10.1016/j.pnpbp.2010.07.005
Robinson S, 2009, BRAIN COGNITION, V71, P362, DOI 10.1016/j.bandc.2009.06.007
Ronald A, 2006, J AM ACAD CHILD PSY, V45, P1206, DOI 10.1097/01.chi.0000230165.54117.41
Rutter M, 2005, J INTELL DISABIL RES, V49, P231, DOI 10.1111/j.1365-2788.2005.00676.x
RUTTER M, 1970, SEMIN PSYCHIAT, V2, P435
Rutter M., 2003, SOCIAL COMMUNICATION
Simonoff E, 2008, J AM ACAD CHILD PSY, V47, P921, DOI 10.1097/CHI.0b013e318179964f
Smith KRM, 2010, RES DEV DISABIL, V31, P743, DOI 10.1016/j.ridd.2010.01.016
Smith KRM, 2010, RES DEV DISABIL, V31, P1062, DOI 10.1016/j.ridd.2010.04.003
Smith KRM, 2010, RES DEV DISABIL, V31, P1366, DOI 10.1016/j.ridd.2010.07.002
Spence SJ, 2009, PEDIATR RES, V65, P599, DOI 10.1203/PDR.0b013e31819e7168
Steffenburg S, 2003, DEV MED CHILD NEUROL, V45, P724, DOI 10.1017/S0012162203001361
Tharp BR, 2004, MENT RETARD DEV D R, V10, P132, DOI 10.1002/mrdd.20025
Tuchman R, 2010, BRAIN DEV-JPN, V32, P709, DOI 10.1016/j.braindev.2010.04.008
Tuchman R, 2010, BRAIN DEV-JPN, V32, P719, DOI 10.1016/j.braindev.2010.05.007
Tuchman R, 2004, MENT RETARD DEV D R, V10, P135, DOI 10.1002/mrdd.20026
Turk J, 2009, ACTA PAEDIATR, V98, P675, DOI 10.1111/j.1651-2227.2008.01184.x
UVEBRANT P, 1994, NEUROPEDIATRICS, V25, P284, DOI 10.1055/s-2008-1073041
Vickerstaff S, 2007, J AUTISM DEV DISORD, V37, P1647, DOI 10.1007/s10803-006-0292-x
Wasserman S, 2006, INT CLIN PSYCHOPHARM, V21, P363, DOI 10.1097/01.yic.0000224787.13782.0f
Wolf P, 2005, ACTA NEUROL SCAND, V112, P5, DOI 10.1111/j.1600-0404.2005.00520.x
World Health Organization, 1993, INT CLASS DIS REL HL
NR 75
TC 11
Z9 11
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1040-7308
J9 NEUROPSYCHOL REV
JI Neuropsychol. Rev.
PD SEP
PY 2012
VL 22
IS 3
BP 271
EP 279
DI 10.1007/s11065-012-9212-3
PG 9
WC Psychology, Clinical; Neurosciences
SC Psychology; Neurosciences & Neurology
GA 998MU
UT WOS:000308244700004
PM 22875726
ER
PT J
AU Stigler, KA
Mullett, JE
Erickson, CA
Posey, DJ
McDougle, CJ
AF Stigler, Kimberly A.
Mullett, Jennifer E.
Erickson, Craig A.
Posey, David J.
McDougle, Christopher J.
TI Paliperidone for irritability in adolescents and young adults with
autistic disorder
SO PSYCHOPHARMACOLOGY
LA English
DT Article
DE Autistic disorder; Irritability; Paliperidone
ID PERVASIVE DEVELOPMENTAL DISORDERS; EXTENDED-RELEASE TABLETS; ABERRANT
BEHAVIOR CHECKLIST; DOUBLE-BLIND; DIAGNOSTIC INTERVIEW; ACUTE
SCHIZOPHRENIA; SPECTRUM DISORDERS; POOLED DATA; OPEN-LABEL; CHILDREN
AB Individuals with autistic disorder (autism) frequently exhibit significant irritability marked by severe tantrums, aggression, and self-injury. Despite advances in the treatment of this symptom domain in autism, there remains an ongoing need for more effective and better tolerated pharmacotherapies.
The aim of this study is to determine the effectiveness and tolerability of paliperidone for irritability in autism.
This is a prospective, 8-week open-label study of paliperidone in 25 adolescents and young adults with autism. Primary outcome measures included the Clinical Global Impressions-Improvement (CGI-I) Scale and the Irritability subscale of the Aberrant Behavior Checklist (ABC-I). Concomitant medications (except antipsychotics) were permitted if dosages were stable for a parts per thousand yen2 months.
Twenty-one (84 %) of 25 subjects ages 12-21 years (mean 15.3 years) responded to paliperidone, based on a CGI-I Scale score of 1 or 2 (very much or much improved) and a parts per thousand yen25 % improvement on the ABC-I. The mean final dosage of paliperidone was 7.1 mg/day (range 3-12 mg/day). Two subjects discontinued paliperidone prior to study completion (moderate sedation, n = 1; nonresponse, n = 1). Mild-to-moderate extrapyramidal symptoms were recorded in four subjects. A mean weight gain of 2.2 +/- 2.6 kg (range -3.6 to +7.9 kg) was recorded. Mean age- and sex-normed body mass index increased from 23.6 to 24.2 (p a parts per thousand currency signaEuro parts per thousand 0.001). Mean serum prolactin increased from 5.3 to 41.4 ng/mL (p a parts per thousand currency signaEuro parts per thousand 0.0001).
Paliperidone treatment was associated with significant improvement in irritability and was generally well tolerated. Larger scale, placebo-controlled studies are needed to elucidate the efficacy and tolerability of paliperidone in this population.
C1 [Stigler, Kimberly A.; Mullett, Jennifer E.; Erickson, Craig A.; Posey, David J.; McDougle, Christopher J.] Indiana Univ Sch Med, Sect Child & Adolescent Psychiat, Christian Sarkine Autism Treatment Ctr, James Whitcomb Riley Hosp Children,Dept Psychiat, Indianapolis, IN 46202 USA.
RP Stigler, KA (reprint author), Indiana Univ Sch Med, Sect Child & Adolescent Psychiat, Christian Sarkine Autism Treatment Ctr, James Whitcomb Riley Hosp Children,Dept Psychiat, 705 Riley Hosp Dr, Indianapolis, IN 46202 USA.
EM kstigler@iupui.edu
FU Daniel X. and Mary Freedman Fellowship in Academic Psychiatry; Janssen
Scientific Affairs, L.L.C.; National Institute of Mental Health (NIMH)
[K23 MH082119]; Indiana Division of Developmental Disability and
Rehabilitative Services; NIMH [R01 MH072964]
FX This study was supported, in part, by a Daniel X. and Mary Freedman
Fellowship in Academic Psychiatry (Dr. Stigler), an
investigator-initiated research grant from Janssen Scientific Affairs,
L.L.C. (Dr. Stigler), a Career Development Award (K23 MH082119) from the
National Institute of Mental Health (NIMH) (Dr. Stigler), the Indiana
Division of Developmental Disability and Rehabilitative Services (Drs.
McDougle and Erickson), and a research grant (R01 MH072964) from the
NIMH (Dr. McDougle).
CR AMAN MG, 1985, AM J MENT DEF, V89, P485
Arnold LE, 2000, J AUTISM DEV DISORD, V30, P99, DOI 10.1023/A:1005451304303
Becker AL, 2006, CHILD ADOL PSYCH CL, V15, P207, DOI 10.1016/j.chc.2005.08.006
Boom S, 2009, J CLIN PHARMACOL, V49, P1318, DOI 10.1177/0091270009339190
Brewer HB, 2011, J CLIN ENDOCR METAB, V96, P1246, DOI 10.1210/jc.2010-0163
Brown EC, 2002, RES DEV DISABIL, V23, P45, DOI 10.1016/S0891-4222(01)00091-9
Canuso CM, 2010, J CLIN PSYCHIAT, V71, P587, DOI 10.4088/JCP.09m05564yel
Chwieduk CM, 2010, DRUGS, V70, P1295, DOI 10.2165/11204840-000000000-00000
Constantino JN, 2003, J AUTISM DEV DISORD, V33, P427, DOI 10.1023/A:1025014929212
Davidson M, 2007, SCHIZOPHR RES, V93, P117, DOI 10.1016/j.schres.2007.03.003
Dremencov E, 2007, PSYCHOPHARMACOLOGY, V194, P63, DOI 10.1007/s00213-007-0818-8
Emsley R, 2008, INT CLIN PSYCHOPHARM, V23, P343, DOI 10.1097/YIC.0b013e328314e1f3
Guy W, 1976, NIMH PUBLICATION
Harrington CA, 2010, INT CLIN PSYCHOPHARM, V25, P334, DOI 10.1097/YIC.0b013e32833db3d8
Kane J, 2007, SCHIZOPHR RES, V90, P147, DOI 10.1016/j.schres.2006.09.012
Karlsson P, 2005, EUR NEUROPSYCHOPHARM, V15, pS386
Kramer M, 2007, J CLIN PSYCHOPHARM, V27, P6, DOI 10.1097/JCP.0b013e31802dda4a
LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
Marcus RN, 2009, J AM ACAD CHILD PSY, V48, P1110, DOI 10.1097/CHI.0b013e3181b76658
Marder SR, 2007, BIOL PSYCHIAT, V62, P1363, DOI 10.1016/j.biopsych.2007.01.017
McDougle CJ, 2005, AM J PSYCHIAT, V162, P1142, DOI 10.1176/appi.ajp.162.6.1142
McDougle CJ, 1998, ARCH GEN PSYCHIAT, V55, P633, DOI 10.1001/archpsyc.55.7.633
McDougle CJ, 1997, J AM ACAD CHILD PSY, V36, P685, DOI 10.1097/00004583-199705000-00020
McPheeters ML, 2011, PEDIATRICS, V127, pE1312, DOI 10.1542/peds.2011-0427
Meltzer HY, 2008, J CLIN PSYCHIAT, V69, P817
Nicolson R, 1998, J AM ACAD CHILD PSY, V37, P372, DOI 10.1097/00004583-199804000-00014
Owen R, 2009, PEDIATRICS, V124, P1533, DOI 10.1542/peds.2008-3782
McCracken JT, 2002, NEW ENGL J MED, V347, P314, DOI 10.1056/NEJMoa013171
Richelson E, 2000, LIFE SCI, V68, P29, DOI 10.1016/S0024-3205(00)00911-5
Robb AS, 2010, DEV DISABIL RES REV, V16, P258, DOI 10.1002/ddrr.118
Roid G., 1997, LEITER INT PERFORMAN
Roid G. H., 2003, STANFORD BINET INTEL
Scahill L, 2006, J AM ACAD CHILD PSY, V45, P1114, DOI 10.1097/01.chi.0000220854.79144.e7
Shea S, 2004, PEDIATRICS, V114, pE634, DOI 10.1542/peds.2003-0264-F
Singh J, 2010, AM AC CHILD AD PSYCH
Sparrow SS, 2005, VINELAND ADAPTIVE BE
Stigler KA, 2010, J CHILD ADOL PSYCHOP, V20, P75, DOI 10.1089/cap.2009.0019
Stigler KA, 2008, CHILD ADOL PSYCH CL, V17, P739, DOI 10.1016/j.chc.2008.06.002
Vermeir M, 2005, EUR NEUROPSYCHOPHA S, V15, pS191
Vieta E, 2010, BIPOLAR DISORD, V12, P230, DOI 10.1111/j.1399-5618.2010.00815.x
NR 40
TC 14
Z9 15
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0033-3158
J9 PSYCHOPHARMACOLOGY
JI Psychopharmacology
PD SEP
PY 2012
VL 223
IS 2
BP 237
EP 245
DI 10.1007/s00213-012-2711-3
PG 9
WC Neurosciences; Pharmacology & Pharmacy; Psychiatry
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA 995IB
UT WOS:000308000400011
PM 22549762
ER
PT J
AU Brookman-Frazee, L
Drahota, A
Stadnick, N
Palinkas, LA
AF Brookman-Frazee, Lauren
Drahota, Amy
Stadnick, Nicole
Palinkas, Lawrence A.
TI Therapist Perspectives on Community Mental Health Services for Children
with Autism Spectrum Disorders
SO ADMINISTRATION AND POLICY IN MENTAL HEALTH AND MENTAL HEALTH SERVICES
RESEARCH
LA English
DT Article
DE Provider perspectives; Autism spectrum disorders; Evidence-based
practices
ID DISRUPTIVE BEHAVIOR PROBLEMS; PSYCHIATRIC-DISORDERS; CARE; YOUTH;
INTERVENTION; COMORBIDITY; POPULATION; PREVALENCE; KNOWLEDGE; WORKING
AB This mixed methods study examined therapist perspectives on serving children with autism spectrum disorders (ASD) in community mental health (CMH) clinics. One hundred therapists completed a survey about their experiences with this population and 17 participated in subsequent focus groups to clarify and expand survey results. Results indicate that CMH therapists serve many children with ASD for behavior or other psychiatric problems and perceive serving this population as challenging and frustrating due to their limited training. Therapists are highly motivated for comprehensive ASD training on ASD characteristics and intervention strategies. These data were used to tailor and package evidence-based intervention strategies for delivery in CMH services.
C1 [Brookman-Frazee, Lauren; Drahota, Amy; Stadnick, Nicole; Palinkas, Lawrence A.] Rady Childrens Hosp San Diego, Child & Adolescent Serv Res Ctr, San Diego, CA 92123 USA.
[Brookman-Frazee, Lauren; Drahota, Amy] Univ Calif San Diego, Dept Psychiat, San Diego, CA 92103 USA.
[Stadnick, Nicole] SDSU UCSD Joint Doctoral Program Clin Psychol, San Diego, CA USA.
[Palinkas, Lawrence A.] Univ So Calif, Sch Social Work, Los Angeles, CA 90089 USA.
RP Brookman-Frazee, L (reprint author), Rady Childrens Hosp San Diego, Child & Adolescent Serv Res Ctr, 3020 Childrens Way,MC 5033, San Diego, CA 92123 USA.
EM lbrookman@ucsd.edu
CR Aarons Gregory A, 2004, Ment Health Serv Res, V6, P61, DOI 10.1023/B:MHSR.0000024351.12294.65
Addis ME, 2000, J CONSULT CLIN PSYCH, V68, P331, DOI 10.1037//0022-006X.68.2.331
[Anonymous], 2009, NAT STAND PROJ ADDR
Beidas RS, 2010, CLIN PSYCHOL-SCI PR, V17, P1
Bickman L., 2000, MENTAL HLTH SERVICES, V2, P71, DOI 10.1023/A:1010100119789
Brookman-Frazee L, 2010, ADM POLICY MENT HLTH, V37, P254, DOI 10.1007/s10488-009-0244-9
Brookman-Frazee L., 2010, INDIVIDUALIZED MENTA
Brookman-Frazee L., J CHILD FAMILY STUDI
Brookman-Frazee L., 2010, ANN M ASS BEH COGN T
Brookman-Frazee LI, 2010, J AUTISM DEV DISORD, V40, P1188, DOI 10.1007/s10803-010-0976-0
Bryson S. E., 2000, AUTISM, V4, P117, DOI DOI 10.1177/1362361300004002002
Centers for Disease Control and Prevention, 2009, MMWR-MORBID MORTAL W, V58, P1
WILLMS DG, 1992, RES METH PR, V3, P189
Dingfelder HE, 2011, J AUTISM DEV DISORD, V41, P597, DOI 10.1007/s10803-010-1081-0
Ganz ML, 2007, ARCH PEDIAT ADOL MED, V161, P343, DOI 10.1001/archpedi.161.4.343
Garland AF, 2001, J AM ACAD CHILD PSY, V40, P409, DOI 10.1097/00004583-200104000-00009
Garland AF, 2010, PSYCHIAT SERV, V61, P788, DOI 10.1176/appi.ps.61.8.788
Gillott A, 2001, AUTISM, V5, P277, DOI 10.1177/1362361301005003005
Glaser B., 1967, DISCOVERY GROUNDED T
Glisson C, 2008, ADM POLICY MENT HLTH, V35, P98, DOI 10.1007/s10488-007-0148-5
Hawley KM, 2005, J CLIN CHILD ADOLESC, V34, P117, DOI 10.1207/s15374424jccp3401_11
Heidgerken AD, 2005, J AUTISM DEV DISORD, V35, P323, DOI 10.1007/s10803-005-3298-x
Hoagwood K, 2009, ADM POLICY MENT HLTH, V36, P35, DOI 10.1007/s10488-008-0201-z
Jensen-Doss A, 2009, PROF PSYCHOL-RES PR, V40, P417, DOI 10.1037/a0014690
Joshi G, 2010, J AUTISM DEV DISORD, V40, P1361, DOI 10.1007/s10803-010-0996-9
Kennedy T, 2004, ACAD MED, V79, P386, DOI 10.1097/00001888-200405000-00006
Lainhart JE, 1999, INT REV PSYCHIATR, V11, P278, DOI 10.1080/09540269974177
Leyfer OT, 2006, J AUTISM DEV DISORD, V36, P849, DOI 10.1007/s10803-006-0123-0
Lord C, 2010, SOCIAL POLICY REPORT, V24, P3
Mandell DS, 2006, J AUTISM DEV DISORD, V36, P475, DOI 10.1007/s10803-006-0088-z
Mandell DS, 2005, J AUTISM DEV DISORD, V35, P313, DOI 10.1007/s10803-005-3296-z
Mandell DS, 2005, ARCH PEDIAT ADOL MED, V159, P266, DOI 10.1001/archpedi.159.3.266
McLennan JD, 2008, J AUTISM DEV DISORD, V38, P1192, DOI 10.1007/s10803-007-0535-5
National Advisory Mental Health Council Workgroup on Child and Adolescent Mental Health Intervention and Deployment, 2001, BLUEPR CHANG RES CHI
National Research Council, 2001, ED CHILDR AUT
Ruble LA, 2005, J AUTISM DEV DISORD, V35, P3, DOI 10.1007/s10803-004-1026-6
Simonoff E, 2008, J AM ACAD CHILD PSY, V47, P921, DOI 10.1097/CHI.0b013e318179964f
Stahmer A. C., 2005, FOCUS AUTISM OTHER D, V20, P66, DOI DOI 10.1177/1088357
Stahmer AC, 2007, J AUTISM DEV DISORD, V37, P1344, DOI 10.1007/s10803-006-0284-x
Westfall JM, 2007, JAMA-J AM MED ASSOC, V297, P403, DOI 10.1001/jama.297.4.403
NR 40
TC 5
Z9 6
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0894-587X
J9 ADM POLICY MENT HLTH
JI Adm. Policy. Ment. Health
PD SEP
PY 2012
VL 39
IS 5
BP 365
EP 373
DI 10.1007/s10488-011-0355-y
PG 9
WC Health Policy & Services; Public, Environmental & Occupational Health
SC Health Care Sciences & Services; Public, Environmental & Occupational
Health
GA 985QS
UT WOS:000307284000004
PM 21533846
ER
PT J
AU Boutte, D
Calhoun, VD
Chen, JY
Sabbineni, A
Hutchison, K
Liu, JY
AF Boutte, David
Calhoun, Vince D.
Chen, Jiayu
Sabbineni, Amithrupa
Hutchison, Kent
Liu, Jingyu
TI Association of genetic copy number variations at 11 q14.2 with brain
regional volume differences in an alcohol use disorder population
SO ALCOHOL
LA English
DT Article
DE Copy number variations; Structural MRI; Genetics; Alcohol dependence
ID AUTISM SPECTRUM DISORDERS; SURFACE-BASED ANALYSIS; CORTICAL GRAY-MATTER;
SEROTONIN TRANSPORTER; DEPENDENCE FAMILIES; CEREBELLAR VOLUME; HUMAN
GENOME; IDENTIFICATION; SCHIZOPHRENIA; COMORBIDITY
AB This study investigates the relationship between genetic copy number variations and brain volume differences in an alcohol use disorder (AUD) population. We hypothesized that copy number variations may influence subject's risk for alcohol use disorders through variations in regional gray and white matter brain volumes. Since genetic influences upon behavior are the result of many complicated interactions we focus on differences in brain volume as a putative intermediate phenotype between genetic variation and behavior. Copy number variation, alcohol use assessments and brain structural magnetic resonance images from 283 subjects, 199 male and 84 females who were enrolled in two AUD studies were obtained and analyzed using a combination of the Freesurfer image analysis suite and independent component analysis. Because brain volume varies by age we compared participant's volume variation with that derived from a control cohort of 75 subjects. In addition we also regressed out the possible brain volume changes induced by long term alcohol consumption. Small cerebral cortex, cerebellar and caudate along with large cerebral white matter and 5th ventricle volumes are shown to be significantly associated with increased AUD severity. When these volume variations are compared with control subject volumes; the variations seen in subjects with AUD are markedly different from normal aging effects. CNVs at 11 q14.2 are marginally (p < 0.05 uncorrected) correlated with such brain volume variations and the correlation holds true after controlling for long-term alcohol consumption; deletion carriers have smaller cerebral cortex, cerebellar, caudate and larger cerebral white matter and 5th ventricle volumes than insertion carriers or subjects with no variation in this region. Similarly, deletion carriers also demonstrate higher AUD severity scores than insertion carriers or subjects with no variation. The results presented here suggest that copy number variation and in particular the variation at chromosome 11 q14.2 may have an impact in brain volume variation, potentially influencing AUD behavior. (c) 2012 Elsevier Inc. All rights reserved.
C1 [Boutte, David; Calhoun, Vince D.; Chen, Jiayu; Sabbineni, Amithrupa; Hutchison, Kent; Liu, Jingyu] Mind Res Network, Albuquerque, NM 87106 USA.
[Calhoun, Vince D.; Chen, Jiayu; Liu, Jingyu] Univ New Mexico, Dept Elect & Comp Engn, Albuquerque, NM 87106 USA.
[Sabbineni, Amithrupa; Hutchison, Kent] Univ Colorado, Dept Psychol & Neurosci, Boulder, CO 80302 USA.
RP Boutte, D (reprint author), Mind Res Network, 1101 Yale Blvd NE, Albuquerque, NM 87106 USA.
EM dboutte@mrn.org
FU National Institutes of Health [1R21DA027626]
FX We are grateful for the help of the MRN Genetics' Lab provided in
collecting the genetic data. This work was supported by grant
1R21DA027626 from the National Institutes of Health.
CR AKAIKE H, 1974, IEEE T AUTOMAT CONTR, VAC19, P716, DOI 10.1109/TAC.1974.1100705
BARRY KL, 1993, ALCOHOL ALCOHOLISM, V28, P33
Bartzokis G, 2000, PSYCHIAT RES-NEUROIM, V98, P93, DOI 10.1016/S0925-4927(99)00052-9
BELL AJ, 1995, NEURAL COMPUT, V7, P1129, DOI 10.1162/neco.1995.7.6.1129
Boyko AR, 2008, PLOS GENET, V4, DOI 10.1371/journal.pgen.1000083
Chen J., 2011, ENG MED BIOL SOC EMB
Claus ED, 2011, NEUROPSYCHOPHARMACOL, V36, P2086, DOI 10.1038/npp.2011.99
Conrad DF, 2010, NATURE, V464, P704, DOI 10.1038/nature08516
Cook EH, 2008, NATURE, V455, P919, DOI 10.1038/nature07458
Dale AM, 1999, NEUROIMAGE, V9, P179, DOI 10.1006/nimg.1998.0395
DELAMONTE SM, 1988, ARCH NEUROL-CHICAGO, V45, P990
Dick DM, 2003, ALCOHOL CLIN EXP RES, V27, P868, DOI 10.1097/01.ALC.0000065436.24221.63
Durand CM, 2007, NAT GENET, V39, P25, DOI 10.1038/ng1933
Durazzo TC, 2011, ALCOHOL CLIN EXP RES, V35, P1187, DOI 10.1111/j.1530-0277.2011.01452.x
Estivill X., 2007, PLOS GENET, V3, pe190, DOI DOI 10.1371/JOURNAL.PGEN.0030190
Fein G, 2002, ALCOHOL CLIN EXP RES, V26, P558, DOI 10.1111/j.1530-0277.2002.tb02574.x
Filbey FM, 2008, ALCOHOL CLIN EXP RES, V32, P1113, DOI 10.1111/j.1530-0277.2008.00692.x
Fischl B, 1999, NEUROIMAGE, V9, P195, DOI 10.1006/nimg.1998.0396
Fotenos AF, 2008, ARCH NEUROL-CHICAGO, V65, P113, DOI 10.1001/archneurol.2007.27
Gonzalez E, 2005, SCIENCE, V307, P1434, DOI 10.1126/science.1101160
Han X, 2006, NEUROIMAGE, V32, P180, DOI 10.1016/j.neuroimage.2006.02.051
HARPER C, 1989, J NEUROL SCI, V92, P81, DOI 10.1016/0022-510X(89)90177-9
Hasin DS, 2007, ARCH GEN PSYCHIAT, V64, P830, DOI 10.1001/archpsyc.64.7.830
HEATHER N, 1993, J STUD ALCOHOL, V54, P700
Heinz A, 2004, AM J PSYCHIAT, V161, P1783, DOI 10.1176/appi.ajp.161.10.1783
Heinzen E., 2009, J ALZHEIMERS DIS
Hendrickson SL, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0012862
Hill SY, 2007, BIOL PSYCHIAT, V61, P41, DOI 10.1016/j.biopsych.2006.01.007
Hill SY, 2011, PSYCHIAT RES-NEUROIM, V194, P304, DOI 10.1016/j.pscychresns.2011.05.006
Hutchison KE, 2008, ALCOHOL CLIN EXP RES, V32, P1111, DOI 10.1111/j.1530-0277.2008.00691.x
Jacob T, 2003, ARCH GEN PSYCHIAT, V60, P1265, DOI 10.1001/archpsyc.60.12.1265
JERNIGAN TL, 1991, ALCOHOL CLIN EXP RES, V15, P418, DOI 10.1111/j.1530-0277.1991.tb00540.x
Jingyu Liu, 2008, IEEE Signal Processing Letters, V15, DOI 10.1109/LSP.2008.922513
Kato M, 2010, HUM MOL GENET, V19, P761, DOI 10.1093/hmg/ddp541
Lichtermann D, 2000, AM J PSYCHIAT, V157, P2045, DOI 10.1176/appi.ajp.157.12.2045
Liu J., 2011, ADDICT BIOL, V70, P537
Liu JY, 2009, HUM BRAIN MAPP, V30, P241, DOI 10.1002/hbm.20508
Martins-de-Souza D, 2010, J PSYCHIATR RES, V44, P1176, DOI 10.1016/j.jpsychires.2010.04.014
Mattson SN, 1996, ALCOHOL CLIN EXP RES, V20, P1088, DOI 10.1111/j.1530-0277.1996.tb01951.x
Meyerhoff DJ, 2006, ALCOHOL CLIN EXP RES, V30, P253, DOI 10.1111/j.1530-0277.2006.00034.x
Nicolas JM, 2000, QJM-MON J ASSOC PHYS, V93, P449, DOI 10.1093/qjmed/93.7.449
Olshen AB, 2004, BIOSTATISTICS, V5, P557, DOI 10.1093/biostatistics/kxh008
PFEFFERBAUM A, 1995, ALCOHOL CLIN EXP RES, V19, P1177, DOI 10.1111/j.1530-0277.1995.tb01598.x
Pfefferbaum A, 1998, ARCH GEN PSYCHIAT, V55, P905, DOI 10.1001/archpsyc.55.10.905
Pinto D, 2010, NATURE, V466, P368, DOI 10.1038/nature09146
Reuter M, 2010, NEUROIMAGE, V53, P1181, DOI 10.1016/j.neuroimage.2010.07.020
Rist F, 2009, DRUG ALCOHOL DEPEN, V100, P71, DOI 10.1016/j.drugalcdep.2008.09.008
Schuckit MA, 1999, BIOL PSYCHIAT, V45, P647, DOI 10.1016/S0006-3223(98)00248-0
Schuster-Bockler B, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009474
Sebat J, 2004, SCIENCE, V305, P525, DOI 10.1126/science.1098918
Segall JM, 2009, SCHIZOPHRENIA BULL, V35, P82, DOI 10.1093/schbul/sbn150
Segonne F, 2004, NEUROIMAGE, V22, P1060, DOI 10.1016/j.neuroimage.2004.03.032
Shevlin M, 2007, ALCOHOL ALCOHOLISM, V42, P582, DOI 10.1093/alcalc/agm045
SKINNER HA, 1982, J ABNORM PSYCHOL, V91, P199, DOI 10.1037//0021-843X.91.3.199
Sullivan EV, 2000, ARCH GEN PSYCHIAT, V57, P894, DOI 10.1001/archpsyc.57.9.894
Uddin M, 2011, J RHEUMATOL, V38, P797, DOI 10.3899/jrheum.100758
Varnas K, 2007, PSYCHIAT CLIN NEUROS, V61, P326, DOI 10.1111/j.1440-1819.2007.01661.x
Vink JM, 2009, AM J HUM GENET, V84, P367, DOI 10.1016/j.ajhg.2009.02.001
Wang K, 2007, GENOME RES, V17, P1665, DOI 10.1101/gr.6861907
Yasseen B, 2010, PSYCHIAT RES, V176, P30, DOI 10.1016/j.psychres.2008.12.009
Yeo RA, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0016339
Yeo RA, 2011, BIOL PSYCHIAT, V70, P537, DOI 10.1016/j.biopsych.2011.04.019
NR 62
TC 5
Z9 5
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0741-8329
J9 ALCOHOL
JI Alcohol
PD SEP
PY 2012
VL 46
IS 6
BP 519
EP 527
DI 10.1016/j.alcohol.2012.05.002
PG 9
WC Substance Abuse; Pharmacology & Pharmacy; Toxicology
SC Substance Abuse; Pharmacology & Pharmacy; Toxicology
GA 993MW
UT WOS:000307864800002
PM 22732324
ER
PT J
AU Vives-Montero, MC
Ascanio-Velasco, L
AF Carmen Vives-Montero, M.
Ascanio-Velasco, Lourdes
TI Treatment results in a case of Asperger disorder
SO BEHAVIORAL PSYCHOLOGY-PSICOLOGIA CONDUCTUAL
LA Spanish
DT Article
DE Asperger's disorder; social skills; treatment; generalization
ID SOCIAL-SKILLS INTERVENTIONS; HIGH-FUNCTIONING CHILDREN; AUTISM SPECTRUM;
ADOLESCENTS
AB This article reports on the treatment of an 8-year-old boy who fulfilled the DSM-IV-TR diagnostic criteria for Asperger disorder (APA, 2000). The boy had poor concentration, disobedience and social skills deficits along with problem behaviors. Training in social skills was used together with a multiple-setting intervention for other contexts (parent training and teacher's cooperation in the school context). The boy's parents used a token economy in the family context and were advised to carry out home-based activities intended to facilitate generalization. After treatment he achieved the planned objectives. His improvements were observed by his teacher and parents and were reflected in test results ("Multifactorial Childhood Adaption Evaluation Test" and "Assertive Behavior Scale for Children"). In addition, there was generalization to other behaviors that were not directly treated, as shown by the disappearance of aggressive behaviors. Therefore, this behavioral intervention demonstrated its effectiveness.
C1 [Carmen Vives-Montero, M.] Univ Granada, Fac Psicol, E-18071 Granada, Spain.
[Ascanio-Velasco, Lourdes] Ctr Psicol CEDI Granada, Granada, Spain.
RP Vives-Montero, MC (reprint author), Univ Granada, Fac Psicol, Campus Cartuja S-N, E-18071 Granada, Spain.
EM cvives@ugr.es
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
Attwood T., 2000, AUTISM, V4, P85, DOI DOI 10.1177/1362361300004001006
Attwood T., 2002, SINDROME ASPERGER GU
Ayllon T, 1974, EC FICHAS
Barnhill G., 2002, FOCUS AUTISM OTHER D, V17, P112, DOI 10.1177/10883576020170020601
Barry TD, 2003, J AUTISM DEV DISORD, V33, P685, DOI 10.1023/B:JADD.0000006004.86556.e0
Bauminger N, 2003, J AUTISM DEV DISORD, V33, P489, DOI 10.1023/A:1025827427901
Beaumont R, 2008, J CHILD PSYCHOL PSYC, V49, P743, DOI 10.1111/j.1469-7610.2008.01920.x
Broderick C, 2002, AUTISM, V6, P427, DOI 10.1177/1362361302006004008
Bonete S, 2010, BEHAV PSYCHOL, V18, P473
Cooper M. J., 1999, FOCUS AUTISM OTHER D, V14, P110, DOI 10.1177/108835769901400207
Couteur A. L., 2006, ENTREVISTA DIAGNOSTI
De la Iglesia M, 2007, AUTISMO SINDROME ASP
De la Iglesia M, 2008, REV PSICOPATOLOGIA P, V13, P1
Fuentes Biggi J., 2006, REV NEUROLOGIA, V43, P425
Gilliam J., 2001, GILLIAM ASPERGERS DI
Gutstein S. E., 2002, FOCUS AUTISM OTHER D, V17, P161, DOI DOI 10.1177/10883576020170030601
Hernandez R, 1990, TEST EVALUATIVO MULT
Jane M. C, 2006, INTERVENCION PSICOLO, P253
Kirk S., 1986, ITPA TEST ILLINOIS A
Krasny L, 2003, CHILD ADOL PSYCH CL, V12, P107, DOI 10.1016/S1056-4993(02)00051-2
Lindner JL, 2006, J AUTISM DEV DISORD, V36, P769, DOI 10.1007/s10803-006-0105-2
Martin Borreguero P, 2005, REV NEUROLOGIA, V41, P115
Martin Borreguero P, 2004, SINDROME ASPERGER EX
Michelson L., 1983, HABILIDADES SOCIALES
Olivar J. S, 2008, INTERVENCION PSICOED
Rao PA, 2008, J AUTISM DEV DISORD, V38, P353, DOI 10.1007/s10803-007-0402-4
Romanczyk R., 2005, J EARLY INTENSIVE BE, V2, P177
Rutter A., 2003, CUESTIONARIO COMUNIC
Sansosti FJ, 2006, J POSIT BEHAV INTERV, V8, P43, DOI 10.1177/10983007060080010601
Simpson RL, 2004, EXCEPT CHILDREN, V70, P135
Sliminng EC, 2007, PSICOL CONDUCT, V15, P253
Solomon M, 2004, J AUTISM DEV DISORD, V34, P649, DOI 10.1007/s10803-004-5286-y
Timler G. R., 2008, ASHA LEADER, V13, P10
Volkmar F. R., 2000, ASPERGER SYNDROME, P340
Volkmar FR, 2004, J CHILD PSYCHOL PSYC, V45, P135, DOI 10.1046/j.0021-9630.2003.00317.x
Webb B. J., 2004, FOCUS AUTISM OTHER D, V19, P53, DOI DOI 10.1177/10883576040190010701
Wechsler D, 1993, TEST INTELIGENCIA WE
Whilliams S. W., 2007, J AUTISM DEV DISORD, V37, P1858
Yirmiya N., 2003, LEARNING BEHAV PROBL, P126
NR 40
TC 0
Z9 0
PU FUNDACION VECA PARA AVANCE PSICOLOGIA
PI GRANADA
PA APARTADO CORREOS 1245, GRANADA, 18080, SPAIN
SN 1132-9483
J9 BEHAV PSYCHOL
JI Behav. Psychol.
PD SEP
PY 2012
VL 20
IS 2
BP 401
EP 419
PG 19
WC Psychology, Clinical
SC Psychology
GA 991HJ
UT WOS:000307691800009
ER
PT J
AU Rutz, HLH
Rothblat, LA
AF Rutz, Hanna L. H.
Rothblat, Lawrence A.
TI Intact and impaired executive abilities in the BTBR mouse model of
autism
SO BEHAVIOURAL BRAIN RESEARCH
LA English
DT Article
DE Autism; Mice; Executive functions; Cognitive control; Response
inhibition; Discrimination learning
ID T PLUS TF/J; COGNITIVE CONTROL; SPECTRUM DISORDERS; CORPUS-CALLOSUM;
INBRED STRAINS; MICE; DISC1; DISCRIMINATION; BEHAVIOR; CORTEX
AB BTBR T + tf/J (BTBR) inbred mice are frequently used as a model of autism spectrum disorders (ASD) as they display social deficits and repetitive behaviors that resemble the symptoms of the human syndrome. Since deficits on tasks that measure cognitive (executive) control are also reliable phenotypes in ASD, we wanted to determine whether executive abilities were compromised in the mouse model. BTBR mice were trained on two visual discrimination paradigms requiring differing degrees of cognitive control. BTBR mice performed normally on a visual discrimination reversal where rule switching was relatively automatic, but were severely impaired on a task-switch paradigm that required the active use of contextual information to switch between rules in a flexible manner. The present findings further characterize the behavior of BTBR mice as a model of ASD. Moreover, the demonstration of both intact and impaired executive functions in BTBR mice illustrates the importance of developing new cognitive assays for comprehensive behavioral assessment of mouse models of human brain disorders. (C) 2012 Elsevier B.V. All rights reserved.
C1 [Rutz, Hanna L. H.; Rothblat, Lawrence A.] George Washington Univ, Dept Psychol, Washington, DC 20052 USA.
RP Rothblat, LA (reprint author), George Washington Univ, Dept Psychol, 2125G St NW, Washington, DC 20052 USA.
EM lar@gwu.edu
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
Amodeo DA, 2012, BEHAV BRAIN RES, V227, P64, DOI 10.1016/j.bbr.2011.10.032
Bolivar VJ, 2007, BEHAV BRAIN RES, V176, P21, DOI 10.1016/j.bbr.2006.09.007
Brigman JL, 2006, BEHAV NEUROSCI, V120, P984, DOI 10.1037/0735-7044.120.4.984
Brigman JL, 2005, BEHAV NEUROSCI, V119, P839, DOI 10.1037/0735-7044.119.3.839
Brigman JL, 2008, BEHAV BRAIN RES, V187, P405, DOI 10.1016/j.bbr.2007.10.004
Brown RE, 2007, CAN J EXP PSYCHOL, V61, P328, DOI 10.1037/cjep2007033
Bussey TJ, 2001, BEHAV NEUROSCI, V115, P957, DOI 10.1037/0735-7044.115.4.957
Chudasama Y, 2003, J NEUROSCI, V23, P8771
Clapcote SJ, 2006, GENETICS, V173, P2407, DOI 10.1534/genetics.106.060749
Davidson MC, 2006, NEUROPSYCHOLOGIA, V44, P2037, DOI 10.1016/j.neuropsychologia.2006.02.006
Diamond A, 2004, AM J PSYCHIAT, V161, P125, DOI 10.1176/appi.ajp.161.1.125
Gould GG, 2011, J NEUROCHEM, V116, P291, DOI 10.1111/j.1471-4159.2010.07104.x
Hikosaka O, 2010, TRENDS COGN SCI, V14, P154, DOI 10.1016/j.tics.2010.01.006
Hill EL, 2004, DEV REV, V24, P189, DOI 10.1016/j.dr.2004.01.001
Kilpinen H, 2008, MOL PSYCHIATR, V13, P187, DOI 10.1038/sj.mp.4002031
Lee FHF, 2011, J NEUROSCI, V31, P3197, DOI 10.1523/JNEUROSCI.4219-10.2011
McFarlane HG, 2008, GENES BRAIN BEHAV, V7, P152, DOI 10.1111/j.1601-183X.2007.00330.x
Moy SS, 2008, BEHAV BRAIN RES, V191, P118, DOI 10.1016/j.bbr.2008.03.015
Moy SS, 2007, BEHAV BRAIN RES, V176, P4, DOI 10.1016/j.bbr.2006.07.030
Osbun N, 2011, AM J MED GENET A, V155A, P1865, DOI 10.1002/ajmg.a.34081
Ozonoff S, 1997, J AUTISM DEV DISORD, V27, P59, DOI 10.1023/A:1025821222046
Ozonoff S, 1999, J AUTISM DEV DISORD, V29, P171, DOI 10.1023/A:1023052913110
Pearson BL, 2011, GENES BRAIN BEHAV, V10, P228, DOI 10.1111/j.1601-183X.2010.00659.x
Pennington BF, 1996, J CHILD PSYCHOL PSYC, V37, P51, DOI 10.1111/j.1469-7610.1996.tb01380.x
Sawamura N, 2006, ANN NY ACAD SCI, V1086, P126, DOI 10.1196/annals.1377.018
Scattoni ML, 2008, PLOS ONE, V3, DOI 10.1371/journal.pone.0003067
Solomon M, 2009, NEUROPSYCHOLOGIA, V47, P2515, DOI 10.1016/j.neuropsychologia.2009.04.019
Solomon M, 2008, INT J DEV NEUROSCI, V26, P239, DOI 10.1016/j.ijdevneu.2007.11.001
Wahlsten D, 2003, BRAIN RES, V971, P47, DOI 10.1016/S0006-8993(03)02354-0
Wohr M, 2011, GENES BRAIN BEHAV, V10, P35, DOI 10.1111/j.1601-183X.2010.00582.x
Yang K, 2011, GENES BRAIN BEHAV, V10, P834, DOI 10.1111/j.1601-183X.2011.00723.x
Yang M, 2009, EUR J NEUROSCI, V29, P1663, DOI 10.1111/j.1460-9568.2009.06714.x
Zagreda L, 1999, J NEUROSCI, V19, P6175
Zou H, 2011, GENES BRAIN BEHAV, V10, P615, DOI 10.1111/j.1601-183X.2011.00702.x
NR 35
TC 8
Z9 8
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0166-4328
J9 BEHAV BRAIN RES
JI Behav. Brain Res.
PD SEP 1
PY 2012
VL 234
IS 1
BP 33
EP 37
DI 10.1016/j.bbr.2012.05.048
PG 5
WC Behavioral Sciences; Neurosciences
SC Behavioral Sciences; Neurosciences & Neurology
GA 991HV
UT WOS:000307693000005
PM 22677272
ER
PT J
AU Dove, G
AF Dove, Guy
TI Grammar as a developmental phenomenon
SO BIOLOGY & PHILOSOPHY
LA English
DT Article
DE Development; Generative entrenchment; Grammar; Innateness; Language
acquisition; Syntax
ID LANGUAGE IMPAIRMENT; DOWN-SYNDROME; BEHAVIORAL-DEVELOPMENT;
WILLIAMS-SYNDROME; ACQUISITION; CHILDREN; AUTISM; SENSITIVITY; SPEECH;
CONSTRAINTS
AB More and more researchers are examining grammar acquisition from theoretical perspectives that treat it as an emergent phenomenon. In this essay, I argue that a robustly developmental perspective provides a potential explanation for some of the well-known crosslinguistic features of early child language: the process of acquisition is shaped in part by the developmental constraints embodied in von Baer's law of development. An established model of development, the Developmental Lock, captures and elucidates the probabilistic generalizations at the heart of von Baer's law. When this model is applied to the acquisition of grammar, it predicts that grammatical achievements that are more generatively entrenched will emerge earlier in development and will be more developmentally resilient than those that are less generatively entrenched. I show that the first prediction is supported by a wealth of psycholinguistic evidence involving typically developing children and that the second prediction is supported by numerous studies involving both children who receive deficient linguistic input and children who experience various language impairments. The success of this model demonstrates the analytic potential of a developmental approach to the study of language acquisition.
C1 Univ Louisville, Dept Philosophy, Louisville, KY 40292 USA.
RP Dove, G (reprint author), Univ Louisville, Dept Philosophy, 313B Humanities Bldg, Louisville, KY 40292 USA.
EM guy.dove@louisville.edu
CR Arthur W, 2002, NATURE, V415, P757
Bates E., 1988, 1 WORDS GRAMMAR INDI
Bates E., 1995, HDB CHILD LANGUAGE, P96
Bavin EL, 2009, CAMBRIDGE HDB CHILD, P259
Behme C, 2008, PHILOS PSYCHOL, V21, P641, DOI 10.1080/09515080802412321
Bishop D. V. M., 1997, UNCOMMON UNDERSTANDI
BLOOM P, 1990, J CHILD LANG, V17, P343
BRAINE MDS, 1976, MONOGR SOC RES CHILD, V41, P1, DOI 10.2307/1165959
Brown R., 1970, COGNITION DEV LANGUA, P11
Brown R., 1973, 1 LANGUAGE EARLY STA
Brown R, 1964, NEW DIRECTIONS STUDY
Brown Roger, 1963, VERBAL BEHAV LEARNIN, P158, DOI 10.1037/11178-005
Chapman RS, 2000, MENT RETARD DEV D R, V6, P84, DOI 10.1002/1098-2779(2000)6:2<84::AID-MRDD2>3.0.CO;2-P
Chomsky N, 1980, RULES REPRESENTATION
Chomsky N., 1986, KNOWLEDGE LANGUAGE I
Chomsky N., 1995, MINIMALIST PROGRAM
CLANCY PM, 1989, J CHILD LANG, V16, P323
Cowie F, 2010, STANF ENCY PHILOS
Crain S., 1998, INVESTIGATIONS UNIVE
Croft W, 2007, COGN LINGUIST, V18, P339, DOI 10.1515/COG.2007.021
Dabrowska E, 2000, COGN LINGUIST, V11, P83
Deen KU, 2009, CAMB HB LANG LINGUIS, P259
DEMUTH K, 1989, LANGUAGE, V65, P56, DOI 10.2307/414842
Diaz MT, 2009, BRAIN RES, V1282, P38, DOI 10.1016/j.brainres.2009.05.043
Diessel Holger, 2004, ACQUISITION COMPLEX
EMMOREY K, 1995, APPL PSYCHOLINGUIST, V16, P1, DOI 10.1017/S0142716400006391
Fabbretti D, 1997, J INTELL DISABIL RES, V41, P165, DOI 10.1111/j.1365-2788.1997.tb00693.x
Fletcher P., 1985, CHILDS LEARNING ENGL
Fowler A. E., 1994, CONSTRAINTS LANGUAGE, P91
Friedmann N, 1997, BRAIN LANG, V56, P397, DOI 10.1006/brln.1997.1795
GERKEN L, 1990, DEV PSYCHOL, V26, P204
Gernsbacher MA, 2005, TRENDS LANG ACQUIS R, V4, P73
Glassmann RB, 1984, EARLY BRAIN DAMAGE, P35
Gleitman Lila, 1990, LANG ACQUIS, V1, P3, DOI DOI 10.1207/S153278171A0101_2
Golinkoff RM, 2001, APPROACHES BOOTSTRAP, P176
GOTTLIEB G, 1991, DEV PSYCHOL, V27, P4, DOI 10.1037/0012-1649.27.1.4
Gould S.J., 1977, ONTOGENY PHYLOGENY
GRIFFITHS PE, 1994, J PHILOS, V91, P277, DOI 10.2307/2940982
Griffiths PE, 1998, PHILOS SCI, V65, P253, DOI 10.1086/392636
GRODZINSKY Y, 1993, LINGUIST INQ, V24, P69
Hirsh-Pasek K., 1996, ORIGINS GRAMMAR EVID
Hoff E, 2006, DEV REV, V26, P55, DOI 10.1016/j.dr.2005.11.002
HOFFGINSBERG E, 1985, J CHILD LANG, V12, P367
Jakubowicz C, 2001, BRAIN LANG, V77, P321, DOI 10.1006/brln.2000.2405
Joan Bresnan, 2001, THEMATIC FUNCTIONAL
Kedar Y, 2006, CHILD DEV, V77, P325, DOI 10.1111/j.1467-8624.2006.00873.x
Kernan T, 1996, J COMMUN DISORD, V29, P401
King J, 1995, NEWSL CTR RES LANG, V2, P1
Kjelgaard MM, 2001, LANG COGNITIVE PROC, V16, P287
Laws G, 2003, J SPEECH LANG HEAR R, V46, P1324, DOI 10.1044/1092-4388(2003/103)
Leonard L. B., 1998, CHILDREN SPECIFIC LA
Leonard LB, 2009, CAMB HB LANG LINGUIS, P433
Leyfer OT, 2008, AUTISM RES, V1, P284, DOI 10.1002/aur.43
Lillo-Martin D, 2009, CAMB HB LANG LINGUIS, P399
Lust BC, 2006, CAMB TEXTBK LINGUIST, P1, DOI 10.2277/ 0521449227
MacWhinney Brian, 1999, EMERGENCE LANGUAGE
Maratsos M. P, 1982, LANGUAGE ACQUISITION, P240
Michel G.E, 1995, DEV PSYCHOBIOLOGY
Miller JF, 2004, MIT ENCY COMMUNICATI, P288
Nelson K., 1973, MONOGRAPHS SOC R 149, V38, P1, DOI 10.2307/1165788
NEVILLE H J, 1992, Cerebral Cortex, V2, P244, DOI 10.1093/cercor/2.3.244
NEWPORT EL, 1991, J PIAGET SY, P111
Newport EL, 1994, LANG ACQUIS, P543
Newport Elissa L., 1988, LANG SCI, V10, P147, DOI DOI 10.1016/0388-0001(88)90010-1
Ospovat D., 1981, DEV DARWINS THEORY N
Oyama S., 2001, CYCLES CONTINGENCY D, P1
Oyama S., 1985, ONTOGENY INFORM DEV
Perovic A, 2001, UCL WORK PAP LINGUIS, V13, P424
Peters A. M., 1995, HDB CHILD LANGUAGE, P462
PINE JM, 1993, J CHILD LANG, V20, P551
Pinker S., 1984, LANGUAGE LEARNABILIT
Pollard Carl, 1994, HEAD DRIVEN PHRASE S
POLLOCK JY, 1989, LINGUIST INQ, V20, P365
Radford A., 1990, SYNTACTIC THEORY ACQ
Radford A, 1995, HDB CHILD LANGUAGE, P483
RASMUSSEN N, 1987, J THEOR BIOL, V127, P271, DOI 10.1016/S0022-5193(87)80107-8
Rice ML, 2003, LANGUAGE COMPETENCE ACROSS POPULATIONS, P63
Rice ML, 2005, APPL PSYCHOLINGUIST, V26, P7, DOI 10.1017/S0142716405050034
Ring M, 2005, J NEUROLINGUIST, V18, P479, DOI 10.1016/j.jneuroling.2005.06.002
Rizzi Luigi, 1993, LANG ACQUIS, V3, P371, DOI 10.1207/s15327817la0304_2
Roberts JA, 2004, APPL PSYCHOLINGUIST, V25, P429, DOI 10.1017/S0142716404001201
Roberts S. S., 1997, 1 LANGUAGE, V17, P131
Rosenberg S, 1993, LANGUAGE COMMUNICATI
Sadock J, 1991, AUTOTHEMATIC SYNTAX
Saffran JR, 1996, SCIENCE, V274, P1926, DOI 10.1126/science.274.5294.1926
Saffran JR, 2003, CURR DIR PSYCHOL SCI, V12, P110, DOI 10.1111/1467-8721.01243
Santelmann LM, 1998, COGNITION, V69, P105, DOI 10.1016/S0010-0277(98)00060-2
Schaner-Wolles C, 2004, WILLIAMS SYNDROME AC, P93
SCHNEIRL.TC, 1966, Q REV BIOL, V41, P283, DOI 10.1086/405056
SHATZ M, 1989, J CHILD LANG, V16, P121
SHIPLEY EF, 1969, LANGUAGE, V45, P322, DOI 10.2307/411663
Simon H. A., 1996, SCI ARTIFICIAL
Slobin D, 1985, CROSSLINGUISTIC STUD, P1157
Soderstrom M, 2007, INFANCY, V12, P1
Soderstrom M, 2002, PROC ANN BUCLD, P643
STECKOL KF, 1979, J COMMUN DISORD, V12, P291, DOI 10.1016/0021-9924(79)90027-3
Tager-Flusberg H, 2004, DEVELOPMENTAL LANGUAGE DISORDERS: FROM PHENOTYPES TO ETIOLOGIES, P31
Tager-Flusberg H., 2007, BLACKWELL HDB LANGUA, P432, DOI 10.1002/9780470757833.ch21
Tomasello M., 2006, HDB CHILD PSYCHOL
Tomasello M., 1992, 1 VERBS CASE STUDY E
Tomasello Michael, 2003, CONSTRUCTING LANGUAG
van der Lely HKJ, 2003, LANGUAGE, V79, P153
van der Lely HKJ, 2005, TRENDS COGN SCI, V9, P53, DOI 10.1016/j.tics.2004.12.002
Vasilyeva M, 2008, DEVELOPMENTAL SCI, V11, P84, DOI 10.1111/j.1467-7687.2007.00656.x
Vasilyeva M, 2006, DEV PSYCHOL, V42, P164, DOI 10.1037/0012-1649.42.1.164
Vicari S, 2000, NEUROPSYCHOLOGIA, V38, P634, DOI 10.1016/S0028-3932(99)00110-4
Wexler K, 2003, LANGUAGE COMPETENCE ACROSS POPULATIONS, P11
Wimsatt W., 2003, REDUCTIONISM DEV KNO, P53
Wimsatt W., 2007, REENGINEERING PHILOS
Wimsatt WC, 2004, MODULARITY IN DEVELOPMENT AND EVOLUTION, P359
Wimsatt William C., 2007, P309
Wimsatt W. C., 1999, BIOL MEETS PSYCHOL P, P139
Wimsatt W. C., 1988, EVOLUTIONARY PROGR, P231
Wimsatt W.C., 2007, INTEGRATING EVOLUTIO, P227
Wimsatt WC, 1986, INTEGRATING SCI DISC, P158
NR 115
TC 3
Z9 3
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0169-3867
EI 1572-8404
J9 BIOL PHILOS
JI Biol. Philos.
PD SEP
PY 2012
VL 27
IS 5
BP 615
EP 637
DI 10.1007/s10539-012-9324-4
PG 23
WC History & Philosophy Of Science
SC History & Philosophy of Science
GA 992FA
UT WOS:000307759800001
ER
PT J
AU Fatemi, SH
Aldinger, KA
Ashwood, P
Bauman, ML
Blaha, CD
Blatt, GJ
Chauhan, A
Chauhan, V
Dager, SR
Dickson, PE
Estes, AM
Goldowitz, D
Heck, DH
Kemper, TL
King, BH
Martin, LA
Millen, KJ
Mittleman, G
Mosconi, MW
Persico, AM
Sweeney, JA
Webb, SJ
Welsh, JP
AF Fatemi, S. Hossein
Aldinger, Kimberly A.
Ashwood, Paul
Bauman, Margaret L.
Blaha, Charles D.
Blatt, Gene J.
Chauhan, Abha
Chauhan, Ved
Dager, Stephen R.
Dickson, Price E.
Estes, Annette M.
Goldowitz, Dan
Heck, Detlef H.
Kemper, Thomas L.
King, Bryan H.
Martin, Loren A.
Millen, Kathleen J.
Mittleman, Guy
Mosconi, Matthew W.
Persico, Antonio M.
Sweeney, John A.
Webb, Sara J.
Welsh, John P.
TI Consensus Paper: Pathological Role of the Cerebellum in Autism
SO CEREBELLUM
LA English
DT Review
DE Cerebellum; Autism
ID FRAGILE-X-SYNDROME; FUNCTIONAL MAGNETIC-RESONANCE; PERVASIVE
DEVELOPMENTAL DISORDERS; LYMPHOCYTE CYTOKINE PROFILES; PURKINJE-CELL
DEGENERATION; TUBEROUS SCLEROSIS COMPLEX; RECEPTOR TYROSINE KINASE;
LHERMITTE-DUCLOS-DISEASE; GAMMA-AMINOBUTYRIC-ACID; MESSENGER-RNA LEVELS
AB There has been significant advancement in various aspects of scientific knowledge concerning the role of cerebellum in the etiopathogenesis of autism. In the current consensus paper, we will observe the diversity of opinions regarding the involvement of this important site in the pathology of autism. Recent emergent findings in literature related to cerebellar involvement in autism are discussed, including: cerebellar pathology, cerebellar imaging and symptom expression in autism, cerebellar genetics, cerebellar immune function, oxidative stress and mitochondrial dysfunction, GABAergic and glutamatergic systems, cholinergic, dopaminergic, serotonergic, and oxytocin-related changes in autism, motor control and cognitive deficits, cerebellar coordination of movements and cognition, gene-environment interactions, therapeutics in autism, and relevant animal models of autism. Points of consensus include presence of abnormal cerebellar anatomy, abnormal neurotransmitter systems, oxidative stress, cerebellar motor and cognitive deficits, and neuroinflammation in subjects with autism. Undefined areas or areas requiring further investigation include lack of treatment options for core symptoms of autism, vermal hypoplasia, and other vermal abnormalities as a consistent feature of autism, mechanisms underlying cerebellar contributions to cognition, and unknown mechanisms underlying neuroinflammation.
C1 [Fatemi, S. Hossein] Univ Minnesota, Sch Med, Minneapolis, MN 55455 USA.
[Aldinger, Kimberly A.] Univ So Calif, Keck Sch Med, Zilkha Neurogenet Inst, Los Angeles, CA 90033 USA.
[Ashwood, Paul] Univ Calif Davis, Dept Med Microbiol & Immunol, Med Invest Neurodev Disorders MIND Inst, Davis, CA 95616 USA.
[Bauman, Margaret L.] Harvard Univ, Sch Med, Boston, MA USA.
[Bauman, Margaret L.] Massachusetts Gen Hosp, Dept Pediat & Neurol, Boston, MA 02114 USA.
[Blaha, Charles D.; Dickson, Price E.; Mittleman, Guy] Univ Memphis, Dept Psychol, Memphis, TN 38152 USA.
[Blatt, Gene J.; Kemper, Thomas L.] Boston Univ, Sch Med, Dept Anat & Neurobiol, Boston, MA 02118 USA.
[Chauhan, Abha; Chauhan, Ved] NYS Inst Basic Res Dev Disabil, Staten Isl, NY USA.
[Dager, Stephen R.] Univ Washington, Dept Radiol, Seattle, WA 98195 USA.
[Dager, Stephen R.] Univ Washington, Dept Bioengn, Seattle, WA 98195 USA.
[Dager, Stephen R.; Estes, Annette M.] Univ Washington, Autism Ctr, Seattle, WA 98195 USA.
[Goldowitz, Dan] Univ British Columbia, Dept Med Genet, Ctr Mol Med & Therapeut, Vancouver, BC, Canada.
[Heck, Detlef H.] Univ Tennessee, Dept Anat & Neurobiol, Hlth Sci Ctr, Memphis, TN USA.
[King, Bryan H.; Webb, Sara J.] Univ Washington, Dept Psychiat & Behav Sci, Seattle Childrens Autism Ctr, Seattle, WA 98195 USA.
[Martin, Loren A.] Azusa Pacific Univ, Dept Psychol, Azusa, CA USA.
[Mosconi, Matthew W.; Sweeney, John A.] Univ Texas SW Med Ctr Dallas, Dept Psychiat, Dallas, TX 75390 USA.
[Mosconi, Matthew W.; Sweeney, John A.] Univ Texas SW Med Ctr Dallas, Dept Pediat, Dallas, TX 75390 USA.
[Persico, Antonio M.] Univ Campus Biomed, Child Neuropsychiat Unit, Lab Mol Psychiat & Neurogenet, Rome, Italy.
[Persico, Antonio M.] IRCCS Fdn Santa Lucia, Dept Expt Neurosci, Rome, Italy.
[Welsh, John P.] Univ Washington, Dept Pediat, Ctr Integrat Brain Res, Seattle Childrens Res Inst, Seattle, WA 98195 USA.
RP Fatemi, SH (reprint author), Univ Minnesota, Sch Med, 420 Delaware St SE,MMC 392, Minneapolis, MN 55455 USA.
EM fatem002@umn.edu
FU Alfred and Ingrid Lenz Harrison Autism Initiative; Autism Speaks
Foundation; Jane Botsford Johnson Foundation; National Alliance for
Research on Schizophrenia and Depression; National Institute of
Neurological Disorders and Stroke [R21HD065269]; Peter Emch Foundation;
Nancy Lurie Marks Family Foundation; NINDS [NS38975-05]; NAAR/Autism
Speaks; Autism Speaks [4853]; NIH/NINDS [R01 NS063009]; Hussman
Foundation; Department of Defense [AS073224P2]; Autism Research
Institute; Autism Collaboration (autism.org); NYS Office for People with
Developmental Disabilities; Autism Centers of Excellence [NICHD
P50-HD055782]; NICHD [HD35465 NICHD, RO1-HD055741]; ACE Network (NICHD)
[HD05571]; American Recovery and Reinvestment Act [NICHD R01-HD065283];
National Institute for Neurological Disorders and Stroke [NINDS
R01-NS31224-18, R01 NS31224-18]; Simons Foundation; NIH [RO1NS060887,
R01NS063009]; Eunice Kennedy Shriver National Institute of Child Health
& Human Development [P50 HD055782]; Autism Center of Excellence from the
Eunice Kennedy Shriver NICHD [P50HD055751]; NIMH [1K23MH092696]; Janssen
Foundation; Italian Ministry of University, Research and Technology
[2006058195, 2008BACT54]; Italian Ministry of Health
[RFPS-2007-5-640174]; Autism Research Institute (San Diego, CA); Autism
Speaks (Princeton, NJ); Fondazione Gaetano e Mafalda Luce (Milan,
Italy); Cure Autism now; Eunice Kennedy Shriver National Institute of
Child Health and Human Development [5R01HD052074-05, 3R01HD05207403-S1]
FX (1) Dr. S. Hossein Fatemi appreciates the excellent technical assistance
by Rachel Elizabeth Kneeland in editing of this consensus paper, and the
critical review of the manuscript by Mr. Timothy D. Folsom. Research
support for Dr. Fatemi's work is from the Eunice Kennedy Shriver
National Institute of Child Health and Human Development
(5R01HD052074-05 and 3R01HD05207403-S1 supplemental grant), as well as
the Alfred and Ingrid Lenz Harrison Autism Initiative; (2) Research
support for work by Drs. Kimberly A. Aldinger and Kathleen J. Millen is
from the Autism Speaks Foundation; (3) Research support for work by Dr.
Paul Ashwood is from Autism Speaks Foundation, the Jane Botsford Johnson
Foundation, National Alliance for Research on Schizophrenia and
Depression, and National Institute of Neurological Disorders and Stroke
R21HD065269, and the Peter Emch Foundation is gratefully acknowledged;
(4) Research support for work by Drs. Margaret L. Bauman and Thomas L.
Kemper is from the Nancy Lurie Marks Family Foundation, by NINDS
(NS38975-05) and by NAAR/Autism Speaks. We would also like to
acknowledge and thank the many families whose generous donation of
postmortem brain tissue has made this research possible; (5) Research
support for work by Drs. Charles D. Blaha, Price E. Dickson, Dan
Goldowitz, Loren A. Martin, and Guy Mittleman is from Cure Autism Now,
Autism Speaks, and R01 NS063009 from NIH/NINDS; (6) Research support for
work by Dr. Gene Blatt is from the Eunice Kennedy Shriver National
Institute of Child Health and Human Development (5R01HD039459-06) and
The Hussman Foundation; (7) Research support for work by Drs. Abha
Chauhan and Ved Chauhan is from the Department of Defense Autism
Spectrum Disorders Research Program AS073224P2, the Autism Research
Institute, the Autism Collaboration (autism.org), and the NYS Office for
People with Developmental Disabilities; (8) Drs. Stephen R. Dager,
Annette M. Estes, and John P. Welsh would like to thank Elizabeth Kelly
for assistance in preparing their manuscript. Research support for their
work is from Autism Centers of Excellence (NICHD P50-HD055782),
Collaborative Programs of Excellence in Autism (NICHD #HD35465 NICHD,
RO1-HD055741), ACE Network (NICHD RO1 supplement HD05571), American
Recovery and Reinvestment Act (NICHD R01-HD065283), and National
Institute for Neurological Disorders and Stroke (NINDS R01-NS31224-18).
Support from Autism Speaks and the Simons Foundation is also gratefully
acknowledged; (9) Research support for Dr. Detlef H. Heck is from NIH
grants RO1NS060887 and R01NS063009. The content of this publication is
solely the responsibility of the author and does not necessarily
represent the official views of the NIH; (10) Research support for Drs.
Bryan H. King, Sara J. Webb, and John P. Welsh is from the Eunice
Kennedy Shriver National Institute of Child Health & Human Development
(P50 HD055782; King/Webb) and the National Institute for Neurological
Disorders and Stroke (R01 NS31224-18; Welsh). We want to thank the
families of and individuals with autism who have participated in
research; (11) Research support for work by Drs. Matthew W. Mosconi and
John A. Sweeney is from the Autism Center of Excellence Award Number
P50HD055751 from the Eunice Kennedy Shriver NICHD, NIMH Grant
1K23MH092696, and Autism Speaks Grant 4853. Dr. John Sweeney consults
with Pfizer and Takeda and has received a grant from the Janssen
Foundation.The content is solely the responsibility of the authors and
does not necessarily represent the official views of the funding
institutes; (12) Research support for work by Dr. Antonio M. Persico is
from the Italian Ministry of University, Research and Technology (PRIN
2006058195 and 2008BACT54), the Italian Ministry of Health
(RFPS-2007-5-640174), Autism Speaks (Princeton, NJ), the Autism Research
Institute (San Diego, CA), and the Fondazione Gaetano e Mafalda Luce
(Milan, Italy).
CR Abrahams BS, 2010, ARCH NEUROL-CHICAGO, V67, P395, DOI 10.1001/archneurol.2010.47
Abrahams BS, 2008, NAT REV GENET, V9, P341, DOI 10.1038/nrg2346
Ackermann H, 1998, NEUROSCI LETT, V247, P187, DOI 10.1016/S0304-3940(98)00328-0
Alkan A, 2005, EUR J RADIOL, V56, P229, DOI 10.1016/j.ejrad.2005.05.008
Allen G, 2003, AM J PSYCHIAT, V160, P262, DOI 10.1176/appi.ajp.160.2.262
Alvarez Retuerto AI, 2008, HUM MOL GENET, V17, P3887, DOI DOI 10.1093/HMG/DDN291.PUBMED:18782849
Amaral DG, 2008, TRENDS NEUROSCI, V31, P137, DOI 10.1016/j.tins.2007.12.005
American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th
Anderson CM, 2002, AM J PSYCHIAT, V159, P1322, DOI 10.1176/appi.ajp.159.8.1322
Andreasen NC, 1998, SCHIZOPHRENIA BULL, V24, P203
ARIN D M, 1991, Neurology, V41, P307
Armstrong DD, 1999, J NEUROPATH EXP NEUR, V58, P1, DOI 10.1097/00005072-199901000-00001
Asahina N, 2008, J PEDIATR, V152, P546, DOI 10.1016/j.jpeds.2007.08.038
Ashwood P, 2004, J CLIN IMMUNOL, V24, P664, DOI 10.1007/s10875-004-6241-6
Ashwood P, 2006, J NEUROIMMUNOL, V173, P126, DOI 10.1016/j.jneuroim.2005.12.007
Ashwood P, 2011, BRAIN BEHAV IMMUN, V25, P40, DOI 10.1016/j.bbi.2010.08.003
Ashwood P, 2009, J NEUROIMMUNOL, V208, P149
Ashwood P, 2008, J NEUROIMMUNOL, V204, P149, DOI 10.1016/j.jneuroim.2008.07.006
Ashwood P, 2011, J NEUROIMMUNOL, V232, P196, DOI 10.1016/j.jneuroim.2010.10.025
Ashwood P, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0019299
Ashwood P, 2011, BRAIN BEHAV IMMUN, V25, P840, DOI 10.1016/j.bbi.2010.09.002
Asperger H., 1991, AUTISM ASPERGER SYND, P37, DOI 10.1017/CBO9780511526770.002
Ayzenshtat I, 2010, J NEUROSCI, V30, P11232, DOI 10.1523/JNEUROSCI.5177-09.2010
Azmitia EC, 2011, NEUROPHARMACOLOGY, V60, P1347, DOI 10.1016/j.neuropharm.2011.02.002
Bailey A, 1998, BRAIN, V121, P889, DOI 10.1093/brain/121.5.889
BAILEY A, 1995, PSYCHOL MED, V25, P63
Banerjee-Basu S, 2010, DIS MODEL MECH, V3, P133, DOI 10.1242/dmm.005439
Bartz JA, 2008, PROG BRAIN RES, V170, P451, DOI 10.1016/S0079-6123(08)00435-4
Baskerville TA, 2010, CNS NEUROSCI THER, V16, pe92, DOI 10.1111/j.1755-5949.2010.00154.x
Bassell GJ, 2008, NEURON, V60, P201, DOI 10.1016/j.neuron.2008.10.004
BAUMAN M, 1985, NEUROLOGY, V35, P866
Bauman M. L., 2005, NEUROBIOLOGY AUTISM
BAUMAN ML, 1991, PEDIATRICS, V87, P791
Bauman ML, 2005, INT J DEV NEUROSCI, V23, P183, DOI 10.1016/j.ijdevneu.2004.09.006
BAUMAN ML, 1995, NEUROPEDIATRICS, V26, P105, DOI 10.1055/s-2007-979737
Bear MF, 2004, TRENDS NEUROSCI, V27, P370, DOI 10.1016/j.tins.2004.04.009
Belichenko NP, 2008, J COMP NEUROL, V508, P184, DOI 10.1002/cne.21673
Bellebaum C, 2007, CEREBELLUM, V6, P184, DOI 10.1080/14734220601169707
Ben-Shaul Y, 2004, J NEUROPHYSIOL, V91, P1748, DOI 10.1152/jn.00957.2003
Bill BR, 2009, CURR OPIN GENET DEV, V19, P271, DOI 10.1016/j.gde.2009.04.004
Blatt GJ, 2005, INT REV NEUROBIOL, V71, P167, DOI 10.1016/S0074-7742(05)71007-2
Blatt GJ, 2001, J AUTISM DEV DISORD, V31, P537, DOI 10.1023/A:1013238809666
Blatt GJ, 2004, SOC NEUROSCI, V34, P11612
BLOEDEL JR, 1978, BRAIN RES, V153, P602, DOI 10.1016/0006-8993(78)90345-1
BRAITENBERG V, 1958, J COMP NEUROL, V109, P1, DOI 10.1002/cne.901090102
Braitenberg V, 1967, Prog Brain Res, V25, P334
Braitenberg V, 1997, BEHAV BRAIN SCI, V20, P229, DOI 10.1017/S0140525X9700143X
Brettler SC, 2003, ANN NY ACAD SCI, V1004, P61, DOI 10.1196/annals.1303.007
Buitelaar JK, 2000, EUR CHILD ADOLES PSY, V9, P185
Burette AC, 2009, J COMP NEUROL, V512, P500, DOI 10.1002/cne.21909
Cabanlit M, 2007, ANN NY ACAD SCI, V1107, P92, DOI 10.1196/annals.1381.010
Campbell DB, 2006, P NATL ACAD SCI USA, V103, P16834, DOI 10.1073/pnas.0605296103
Campbell DB, 2007, ANN NEUROL, V62, P243, DOI 10.1002/ana.21180
Campbell DB, 2008, AUTISM RES, V1, P159, DOI 10.1002/aur.27
Carayol J, 2011, BIOL PSYCHIAT, V70, P880, DOI 10.1016/j.biopsych.2011.05.020
Careaga M, 2010, NEUROTHERAPEUTICS, V7, P283, DOI 10.1016/j.nurt.2010.05.003
Carlson GC, 2012, PHARMACOL BIOCHEM BE, V100, P850, DOI 10.1016/j.pbb.2011.02.003
Casanova MF, 2007, BRAIN PATHOL, V17, P422, DOI 10.1111/j.1750-3639.2007.00100.x
Catani M, 2008, NEUROIMAGE, V41, P1184, DOI 10.1016/j.neuroimage.2008.03.041
Chauhan A, 2011, J NEUROCHEM S1, V118, P217
Chauhan A, 2011, T AM SOC NEUROCHEMIS, P81
Chauhan A, 2010, INT M AUST RES MAY
Chauhan Abha, 2006, Pathophysiology, V13, P171, DOI 10.1016/j.pathophys.2006.05.007
Chauhan A, 2010, Autism: Oxidative Stress, Inflammation, and Immune Abnormalities, P1
Chauhan A, 2011, J NEUROCHEM, V117, P209, DOI 10.1111/j.1471-4159.2011.07189.x
Cheh MA, 2006, BRAIN RES, V1116, P166, DOI 10.1016/j.brainres.2006.07.086
Cheung C, 2009, J CHILD PSYCHOL PSYC, V50, P1102, DOI 10.1111/j.1469-7610.2009.02086.x
Chez MG, 2007, PEDIATR NEUROL, V36, P361, DOI 10.1016/j.pediatrneurol.2007.01.012
Ciesielski KT, 1997, NEUROPSYCHOLOGIA, V35, P643, DOI 10.1016/S0028-3932(96)00119-4
Corbett BA, 2007, MOL PSYCHIATR, V12, P292, DOI 10.1038/sj.mp.4001943
COURCHESNE E, 1988, NEW ENGL J MED, V318, P1349, DOI 10.1056/NEJM198805263182102
Courchesne E, 1997, CURR OPIN NEUROBIOL, V7, P269, DOI 10.1016/S0959-4388(97)80016-5
COURCHESNE E, 1994, LANCET, V343, P63, DOI 10.1016/S0140-6736(94)90923-7
Courchesne E, 2011, JAMA-J AM MED ASSOC, V306, P2001, DOI 10.1001/jama.2011.1638
COURCHESNE E, 1995, J AUTISM DEV DISORD, V25, P19, DOI 10.1007/BF02178164
COURCHESNE E, 1994, AM J ROENTGENOL, V162, P123
Crandall JE, 2007, J NEUROSCI, V27, P3813, DOI 10.1523/JNEUROSCI.5124-06.2007
Cremer CM, 2011, BRAIN STRUCT FUNCT, V216, P201, DOI 10.1007/s00429-011-0303-3
Crepel F, 2007, J NEUROPHYSIOL, V97, P824, DOI 10.1152/jn.00735.2006
Dager Stephen R, 2008, Top Magn Reson Imaging, V19, P81, DOI 10.1097/RMR.0b013e318181e0be
Dager SR, 2011, AUTISM SPECTRUM DISO
D'Amelio M, 2005, MOL PSYCHIATR, V10, P1006, DOI 10.1038/sj.mp.4001714
D'Arcangelo G, 1999, NEURON, V24, P471, DOI 10.1016/S0896-6273(00)80860-0
DARCANGELO G, 1995, NATURE, V374, P719, DOI 10.1038/374719a0
DEBASSIO WA, 1985, ARCH NEUROL-CHICAGO, V42, P350
DeLorey TM, 2008, BEHAV BRAIN RES, V187, P207, DOI 10.1016/j.bbr.2007.09.009
Demark JL, 2003, AM J MENT RETARD, V108, P314, DOI 10.1352/0895-8017(2003)108<314:BRBAAF>2.0.CO;2
De Rubeis S, 2010, MOL CELL NEUROSCI, V43, P43, DOI 10.1016/j.mcn.2009.09.013
DeScipio C, 2005, AM J MED GENET A, V134A, P3, DOI 10.1002/ajmg.a.30573
Deth R, 2008, NEUROTOXICOLOGY, V29, P190, DOI 10.1016/j.neuro.2007.09.010
Deutsch SI, 2010, CLIN NEUROPHARMACOL, V33, P114, DOI 10.1097/WNF.0b013e3181d6f7ad
Dickson PE, 2010, NEUROBIOL LEARN MEM, V94, P220, DOI 10.1016/j.nlm.2010.05.010
Dindot SV, 2008, HUM MOL GENET, V17, P111, DOI 10.1093/hmg/ddm288
Dulabon L, 2000, NEURON, V27, P33, DOI 10.1016/S0896-6273(00)00007-6
Ellegood J, 2010, NEUROIMAGE, V53, P1023, DOI 10.1016/j.neuroimage.2010.03.038
Elsen Gina E, 2009, Dev Biol, V335, P78, DOI 10.1016/j.ydbio.2009.08.024
Eluvathingal TJ, 2006, J CHILD NEUROL, V21, P846, DOI 10.2310/7010.2006.00192
Empson RM, 2007, J NEUROSCI, V27, P3753, DOI 10.1523/JNEUROSCI.0069-07.2007
Enstrom A, 2009, BRAIN BEHAV IMMUN, V23, P389, DOI 10.1016/j.bbi.2008.12.005
Enstrom AM, 2010, BRAIN BEHAV IMMUN, V24, P64, DOI 10.1016/j.bbi.2009.08.001
Enstrom AM, 2009, BRAIN BEHAV IMMUN, V23, P124, DOI 10.1016/j.bbi.2008.08.001
Eskenazi B, 2010, ENVIRON HEALTH PERSP, V118, P1775, DOI 10.1289/ehp.1002234
Evans T. A., 2008, AM J BIOCH BIOTECHNO, V4, P61, DOI DOI 10.3844/AJBBSP.2008.61.72
Fatemi SH, 2011, MOL AUTISM, V2, DOI 10.1186/2040-2392-2-6
Fatemi SH, 2011, NEUROPHARMACOLOGY, V60, P1221, DOI 10.1016/j.neuropharm.2010.11.011
Fatemi SH, 2002, CELL MOL NEUROBIOL, V22, P139, DOI 10.1023/A:1019857620251
Fatemi SH, 2001, J AUTISM DEV DISORD, V31, P529, DOI 10.1023/A:1013234708757
Fatemi SH, 2010, J AUTISM DEV DISORD, V40, P743, DOI 10.1007/s10803-009-0924-z
Fatemi SH, 2009, CEREBELLUM, V8, P64, DOI 10.1007/s12311-008-0075-3
Fatemi SH, 2011, ANAT REC, V294, P1635, DOI 10.1002/ar.21299
Fatemi SH, 2002, CELL MOL NEUROBIOL, V22, P171, DOI 10.1023/A:1019861721160
Fatemi SH, 2002, BIOL PSYCHIAT, V52, P805, DOI 10.1016/S0006-3223(02)01430-0
Fatemi SH, 2005, BIOL PSYCHIAT, V57, P777, DOI 10.1016/j.biopsych.2004.12.018
Fatemi SH, 2009, J AUTISM DEV DISORD, V39, P223, DOI 10.1007/s10803-008-0646-7
Ferguson JN, 2001, J NEUROSCI, V21, P8278
Fink M, 2006, INT REV NEUROBIOL, V72, P233, DOI 10.1016/S0074-7742(05)72014-6
Fombonne E, 2005, J CLIN PSYCHIAT, V66, P3
Forster E, 2002, P NATL ACAD SCI USA, V99, P13178, DOI 10.1073/pnas.202035899
Fournier KA, 2010, J AUTISM DEV DISORD, V40, P1227, DOI 10.1007/s10803-010-0981-3
Freitag CM, 2007, J AUTISM DEV DISORD, V37, P948, DOI 10.1007/s10803-006-0235-6
Gaita L, 2010, PSYCHIAT RES, V180, P105, DOI 10.1016/j.psychres.2010.04.010
Garbett K, 2008, NEUROBIOL DIS, V30, P303, DOI 10.1016/j.nbd.2008.01.012
GARCIA CA, 1973, DEV MED CHILD NEUROL, V15, P48
Garside ML, 2009, NEUROSCIENCE, V162, P383, DOI 10.1016/j.neuroscience.2009.04.059
Gerwig M, 2008, EXP BRAIN RES, V187, P85, DOI 10.1007/s00221-008-1283-2
Geschwind DH, 2007, CURR OPIN NEUROBIOL, V17, P103, DOI 10.1016/j.conb.2007.01.009
Geschwind DH, 2008, CELL, V135, P391, DOI 10.1016/j.cell.2008.10.016
Giza J, 2010, J NEUROSCI, V30, P14805, DOI 10.1523/JNEUROSCI.1161-10.2010
Goines P, 2011, BRAIN BEHAV IMMUN, V25, P514, DOI 10.1016/j.bbi.2010.11.017
Gordon N, 2007, EUR J PAEDIATR NEURO, V11, P232, DOI 10.1016/j.ejpn.2007.02.003
Greenfield JG, 1954, SPINOCEREBELLAR DEGE
Hallmayer J, 2011, ARCH GEN PSYCHIAT, V68, P1095, DOI 10.1001/archgenpsychiatry.2011.76
Hardan A.Y., 2009, BIOL PSYCHIAT, V66, P313
HASHIMOTO H, 1985, ENDOCRINOL JAPON, V32, P89
HAWKES R, 1991, PROG NEUROBIOL, V36, P309, DOI 10.1016/0301-0082(91)90004-K
HAWKES R, 1985, BRAIN RES, V333, P359, DOI 10.1016/0006-8993(85)91593-8
Hazlett HC, 2005, ARCH GEN PSYCHIAT, V62, P1366, DOI 10.1001/archpsyc.62.12.1366
HECK D, 1995, NATURWISSENSCHAFTEN, V82, P201, DOI 10.1007/BF01143198
HECK D, 1993, NEUROSCI LETT, V157, P95, DOI 10.1016/0304-3940(93)90651-Z
Herbert MR, 2002, ANN NEUROL, V52, P588, DOI 10.1002/ana.10349
Heuer L, 2008, AUTISM RES, V1, P275, DOI 10.1002/aur.42
Hiesberger T, 1999, NEURON, V24, P481, DOI 10.1016/S0896-6273(00)80861-2
Hodge SM, 2010, J AUTISM DEV DISORD, V40, P300, DOI 10.1007/s10803-009-0872-7
HOEHNSARIC R, 1991, BIOL PSYCHIAT, V30, P170, DOI 10.1016/0006-3223(91)90171-H
Hollander E, 2003, NEUROPSYCHOPHARMACOL, V28, P193, DOI 10.1038/sj.npp.1300021
Hollander E, 2007, BIOL PSYCHIAT, V61, P498, DOI 10.1016/j.bipsych.2006.05.030
Holmes G, 1908, BRAIN, V31, P125, DOI 10.1093/brain/31.1.125
Hong SE, 2000, NAT GENET, V26, P93
Ieraci A, 2002, P NATL ACAD SCI USA, V99, P15200, DOI 10.1073/pnas.222362099
Ingram JL, 2000, TERATOLOGY, V62, P393, DOI 10.1002/1096-9926(200012)62:6<393::AID-TERA6>3.0.CO;2-V
Insel TR, 2001, NAT REV NEUROSCI, V2, P129, DOI 10.1038/35053579
IVRY RB, 1988, EXP BRAIN RES, V73, P167, DOI 10.1007/BF00279670
Ji LN, 2009, LIFE SCI, V85, P788, DOI 10.1016/j.lfs.2009.10.008
Johnson MB, 2009, NEURON, V62, P494, DOI 10.1016/j.neuron.2009.03.027
Kanner L, 1943, NERV CHILD, V2, P217
Kates WR, 2004, AM J PSYCHIAT, V161, P539, DOI 10.1176/appi.ajp.161.3.539
Kaufmann WE, 2003, J CHILD NEUROL, V18, P463, DOI 10.1177/08830738030180070501
Kelemenova S, 2010, PSYCHIAT GENET, V20, P137, DOI 10.1097/YPG.0b013e32833a1eb3
Kelly RM, 2003, J NEUROSCI, V23, P8432
Kemper TL, 1998, J NEUROPATH EXP NEUR, V57, P645, DOI 10.1097/00005072-199807000-00001
Kemper TL, 2010, NEUROCHEMICAL BASIS OF AUTISM: FROM MOLECULES TO MINICOLUMNS, P69, DOI 10.1007/978-1-4419-1272-5_5
Kern JK, 2006, J TOXICOL ENV HEAL B, V9, P485, DOI 10.1080/10937400600882079
Kim SA, 2007, NEUROSCI RES, V58, P332, DOI 10.1016/j.neures.2007.03.002
Kinney DK, 2008, NEUROSCI BIOBEHAV R, V32, P1519, DOI 10.1016/j.neubiorev.2008.06.004
Kirsch P, 2010, NEUROCHEMICAL BASIS OF AUTISM: FROM MOLECULES TO MINICOLUMNS, P163, DOI 10.1007/978-1-4419-1272-5_10
Kish SJ, 2005, NUCL MED BIOL, V32, P123, DOI 10.1016/j.nucmedbio.2004.10.001
Kolasiewicz W, 2011, CEREBELLUM, V10, P267, DOI 10.1007/s12311-011-0250-9
Kolevzon A, 2007, ARCH PEDIAT ADOL MED, V161, P326, DOI 10.1001/archpedi.161.4.326
Krey JF, 2007, CURR OPIN NEUROBIOL, V17, P112, DOI 10.1016/j.conb.2007.01.010
Kuemerle B, 2007, BEHAV BRAIN RES, V176, P121, DOI 10.1016/j.bbr.2006.09.009
Kwon CH, 2001, NAT GENET, V29, P404, DOI 10.1038/ng781
Lainhart JE, 2006, AM J MED GENET A, V140A, P2257, DOI 10.1002/ajmg.a.31465
Lancaster MA, 2011, NAT MED, V17, P726, DOI 10.1038/nm.2380
Landmark CJ, 2008, CNS DRUGS, V22, P27
Landrigan PJ, 2010, CURR OPIN PEDIATR, V22, P219, DOI 10.1097/MOP.0b013e328336eb9a
Lee M, 2002, BRAIN, V125, P1483, DOI 10.1093/brain/awf160
LEINER HC, 1986, BEHAV NEUROSCI, V100, P443, DOI 10.1037//0735-7044.100.4.443
Lenaz G, 2001, IUBMB LIFE, V52, P159, DOI 10.1080/15216540152845957
Lepagnol-Bestel AM, 2008, MOL PSYCHIATR, V13, P385, DOI 10.1038/sj.mp.4002120
Li XH, 2009, J NEUROIMMUNOL, V207, P111, DOI 10.1016/j.jneuroim.2008.12.002
Lippiello PM, 2006, MED HYPOTHESES, V66, P985, DOI 10.1016/j.mehy.2005.11.015
Lisman J, 2003, PHILOS T ROY SOC B, V358, P829, DOI 10.1098/rstb.2002.1242
Liu WS, 2005, NEUROL RES, V27, P339, DOI 10.1179/016164105X35602
Llinas R, 1997, LEARN MEMORY, V3, P445, DOI 10.1101/lm.3.6.445
Llinas RR, 2002, 1 VORTEX NEURONS SEL
Lopez BR, 2005, J AUTISM DEV DISORD, V35, P445, DOI 10.1007/s10803-005-5035-x
Lopez-Hurtado E., 2008, AM J BIOCH BIOTECHNO, V4, P130, DOI DOI 10.3844/AJBBSP.2008.130.145
Lory P, 2010, IDRUGS, V13, P467
Lugli Giovanni, 2003, BMC Biochem, V4, P9, DOI 10.1186/1471-2091-4-9
Makkonen I, 2008, DEV MED CHILD NEUROL, V50, P593, DOI 10.1111/j.1469-8749.2008.03027.x
Manni E, 2004, NAT REV NEUROSCI, V5, P241, DOI 10.1038/nrn1347
Marazziti D, 2002, BIOL PSYCHIAT, V52, P143, DOI 10.1016/S0006-3223(02)01406-3
Martin LA, 2006, BEHAV NEUROSCI, V120, P477, DOI 10.1037/0735-7044.120.2.477
Martin LA, 2010, EUR J NEUROSCI, V31, P544, DOI 10.1111/j.1460-9568.2009.07073.x
Martin LA, 2004, GENES BRAIN BEHAV, V3, P158, DOI 10.1111/j.1601-183x.2004.00067.x
Martin-Ruiz CM, 2004, MOL BRAIN RES, V123, P81, DOI 10.1016/j.molbrainres.2004.01.003
Mattson MP, 2008, ANN NY ACAD SCI, V1144, P97, DOI 10.1196/annals.1418.005
McCarthy MM, 1996, PHYSIOL BEHAV, V60, P1209
Middleton FA, 2001, J NEUROSCI, V21, P700
Middleton FA, 1997, INT REV NEUROBIOL, V41, P61
Miles JH, 2011, GENET MED, V13, P278, DOI 10.1097/GIM.0b013e3181ff67ba
Miles JH, 2000, AM J MED GENET, V91, P245, DOI 10.1002/(SICI)1096-8628(20000410)91:4<245::AID-AJMG1>3.0.CO;2-2
Minshew NJ, 2004, NEUROLOGY, V63, P2056
Mittleman G, 2008, SYNAPSE, V62, P544, DOI 10.1002/syn.20525
Moessner R, 2007, AM J HUM GENET, V81, P1289, DOI 10.1086/522S90
Molinari M, 2008, CEREBELLUM, V7, P611, DOI 10.1007/s12311-008-0060-x
Molloy CA, 2003, J AUTISM DEV DISORD, V33, P643, DOI 10.1023/B:JADD.0000006001.00667.4c
Mosconi MW, 2010, ARCH GEN PSYCHIAT, V67, P830, DOI 10.1001/archgenpsychiatry.2010.87
Mostofsky SH, 2009, BRAIN, V132, P2413, DOI 10.1093/brain/awp088
Muddashetty RS, 2007, J NEUROSCI, V27, P5338, DOI 10.1523/JNEUROSCI.0937-07.2007
Mullen B, 2010 NEUR M PLANN
Muller RA, 2001, BIOL PSYCHIAT, V49, P665, DOI 10.1016/S0006-3223(00)01004-0
Muthaiyah B, 2009, J NEUROCHEM, V108, P73
Nakamura K, 2010, ARCH GEN PSYCHIAT, V67, P58
Nowinski CV, 2005, PSYCHIAT RES, V137, P11, DOI 10.1016/j.psychres.2005.07.005
Nullmeier S, 2011, EUR J NEUROSCI, V33, P689, DOI 10.1111/j.1460-9568.2010.07563.x
Oblak A, 2009, AUTISM RES, V2, P205, DOI 10.1002/aur.88
Oblak AL, 2010, J NEUROCHEM, V114, P1414, DOI 10.1111/j.1471-4159.2010.06858.x
OHearn E, 1997, J NEUROSCI, V17, P8828
Onore C, 2009, J NEUROIMMUNOL, V216, P126, DOI 10.1016/j.jneuroim.2009.09.005
Oristaglio J, 2012, SOC NEUR AB IN PRESS
Ozonoff S, 2008, J AUTISM DEV DISORD, V38, P644, DOI 10.1007/s10803-007-0430-0
Ozonoff S, 1999, J CHILD NEUROL, V14, P636, DOI 10.1177/088307389901401003
PADBERG GW, 1991, ANN NEUROL, V29, P517, DOI 10.1002/ana.410290511
Palmen SJMC, 2004, BRAIN, V127, P2572, DOI 10.1093/brain/awh287
Palmieri L, 2010, BBA-BIOENERGETICS, V1797, P1130, DOI 10.1016/j.bbabio.2010.04.018
Park YG, 2010, P NATL ACAD SCI USA, V107, P10731, DOI 10.1073/pnas.1002995107
Pasca SP, 2006, LIFE SCI, V78, P2244, DOI 10.1016/j.lfs.2005.09.040
Pennington BF, 1996, J CHILD PSYCHOL PSYC, V37, P51, DOI 10.1111/j.1469-7610.1996.tb01380.x
Persico AM, 2006, J NEURAL TRANSM, V113, P1373, DOI 10.1007/s00702-006-0441-6
Persico AM, 2006, TRENDS NEUROSCI, V29, P349, DOI 10.1016/j.tins.2006.05.010
Persico AM, 2001, MOL PSYCHIATR, V6, P150, DOI 10.1038/sj.mp.4000850
Pesold C, 1998, P NATL ACAD SCI USA, V95, P3221, DOI 10.1073/pnas.95.6.3221
Pessah IN, 2010, PHARMACOL THERAPEUT, V125, P260, DOI 10.1016/j.pharmthera.2009.10.009
Philippe A, 2008, PEDIATRICS, V122, pE376, DOI 10.1542/peds.2007-2584
Placantonakis DG, 2001, J PHYSIOL-LONDON, V534, P123, DOI 10.1111/j.1469-7793.2001.t01-1-00123.x
Placantonakis DG, 2000, J PHYSIOL-LONDON, V524, P833, DOI 10.1111/j.1469-7793.2000.00833.x
Prut Y, 1998, J NEUROPHYSIOL, V79, P2857
Purcell AE, 2001, NEUROLOGY, V57, P1618
Quattrocchi CC, 2002, J BIOL CHEM, V277, P303, DOI 10.1074/jbc.M106996200
Rasalam AD, 2005, DEV MED CHILD NEUROL, V47, P551, DOI 10.1017/S0012162205001076
Reith RM, 2011, NEUROBIOL DIS, V43, P113, DOI 10.1016/j.nbd.2011.02.014
Rice D, 2000, ENVIRON HEALTH PERSP, V108, P511, DOI 10.2307/3454543
RITVO ER, 1986, AM J PSYCHIAT, V143, P862
Rogers TD, 2011, SYNAPSE, V65, P1204, DOI 10.1002/syn.20960
Rojas DC, 2006, BMC PSYCHIATRY, V6, DOI 10.1186/1471-244X-6-56
Rossignol DA, 2012, MOL PSYCHIATR, V17, P290, DOI 10.1038/mp.2010.136
Sajdel-Sulkowska EM, 2008, AM J BIOCH BIOTECHNO, V4, P73
Sajdel-Sulkowska EM, 2009, CEREBELLUM, V8, P366, DOI 10.1007/s12311-009-0105-9
Sakurai T, 2010, BIOL PSYCHIAT, V67, P887, DOI 10.1016/j.biopsych.2009.08.042
Sarna JR, 2003, PROG NEUROBIOL, V70, P473, DOI 10.1016/S0301-0082(03)00114-X
SASAKI K, 1993, INT CONGR SER, V1024, P41
Schaaf CP, 2011, NEURON, V70, P806, DOI 10.1016/j.neuron.2011.05.025
Schmahmann J, 1997, INT REV NEUROBIOLOGY, V41
Schmahmann JD, 1998, BRAIN, V121, P561, DOI 10.1093/brain/121.4.561
Schmahmann JD, 2004, J COMP NEUROL, V478, P248, DOI 10.1002/cne.20286
Schmahmann JD, 2007, CEREBELLUM, V6, P254, DOI 10.1080/14734220701490995
Schmitz C, 2008, NEUROPATH APPL NEURO, V34, P4, DOI 10.1111/j.1365-2990.2007.00872.x
Scott JA, 2009, AUTISM RES, V2, P246, DOI 10.1002/aur.97
Sheng L, 2010, TOXICOL SCI, V118, P625, DOI 10.1093/toxsci/kfq304
Shriberg LD, 2011, J AUTISM DEV DISORD, V41, P405, DOI 10.1007/s10803-010-1117-5
Silverman JM, 2008, AM J MED GENET B, V147B, P408, DOI 10.1002/ajmg.b.30614
Sinagra M, 2008, NEURON GLIA BIOL, V4, P189, DOI 10.1017/S1740925X09990214
Stanfield AC, 2008, EUR PSYCHIAT, V23, P289, DOI 10.1016/j.eurpsy.2007.05.006
Steinlin M, 2007, CEREBELLUM, V6, P237, DOI 10.1080/14734220701344507
Steinlin M, 2008, CEREBELLUM, V7, P607, DOI 10.1007/s12311-008-0083-3
Stoodley CJ, 2012, CEREBELLUM IN PRESS
Stoodley CJ, 2009, NEUROIMAGE, V44, P489, DOI 10.1016/j.neuroimage.2008.08.039
Strasser V, 2004, MOL CELL BIOL, V24, P1378, DOI 10.1128/MCD.24.3.1378-1386.2004
Strick PL, 2009, ANNU REV NEUROSCI, V32, P413, DOI 10.1146/annurev.neuro.31.060407.125606
Strutz-Seebohm N, 2006, CELL PHYSIOL BIOCHEM, V18, P287, DOI 10.1159/000097675
Swanson DJ, 2011, DEV BIOL, V351, P1, DOI 10.1016/j.ydbio.2010.11.018
Tager-Flusberg H, 2007, PEDIATR CLIN N AM, V54, P469, DOI 10.1016/j.pcl.2007.02.011
Takahashi T, 2006, NEUROSCI RES, V54, P104, DOI 10.1016/j.neures.2005.10.012
Takarae Y, 2007, PSYCHIAT RES-NEUROIM, V156, P117, DOI 10.1016/j.pseychresns.2007.03.008
Takarae Y, 2004, BRAIN, V127, P2584, DOI 10.1093/brain/awh307
Takarae Y, 2004, J NEUROL NEUROSUR PS, V75, P1359, DOI 10.1136/jnnp.2003.022491
Tan GCY, 2010, NEUROIMAGE, V53, P1030, DOI 10.1016/j.neuroimage.2010.02.018
Townsend J, 1999, J NEUROSCI, V19, P5632
Uemura T, 2010, CELL, V141, P1068, DOI 10.1016/j.cell.2010.04.035
Umeda T, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0015500
van der Vaart T, 2011, GENES BRAIN BEHAV, V10, P404, DOI 10.1111/j.1601-183X.2011.00685.x
Vargas DL, 2005, ANN NEUROL, V57, P67, DOI 10.1002/ana.20315
Voineagu I, 2011, NATURE, V474, P380, DOI 10.1038/nature10110
Wang P, 2011, INT M AUT RES 2011 M
Wassink TH, 2004, MENT RETARD DEV D R, V10, P272, DOI 10.1002/mrdd.20041
Webb SJ, 2009, PSYCHIAT RES-NEUROIM, V172, P61, DOI 10.1016/j.pscychresns.2008.06.001
Weeber EJ, 2002, J BIOL CHEM, V277, P39944, DOI 10.1074/jbc.M205147200
Wegiel J, 2009, AUTISM OXIDATIVE STR, P1, DOI 10.1201/9781420068870-c1
Wei HG, 2011, J NEUROINFLAMM, V8, DOI 10.1186/1742-2094-8-52
Wells PG, 2009, TOXICOL SCI, V108, P4, DOI 10.1093/toxsci/kfn263
Welsh JP, 2005, INT J DEV NEUROSCI, V23, P253, DOI 10.1016/j.ijdevneu.2004.09.002
Welsh JP, 2002, ADV NEUROL, V89, P331
Welsh JP, 2011, P NATL ACAD SCI USA, V108, P10314, DOI 10.1073/pnas.1017079108
Welsh JP, 2010, SOC NEUR ABSTR, P525
Welsh JP, 1997, PROG BRAIN RES, V114, P449
WELSH JP, 1995, NATURE, V374, P453, DOI 10.1038/374453a0
Whitney ER, 2009, J NEUROSCI RES, V87, P2245, DOI 10.1002/jnr.22056
Whitney ER, 2008, CEREBELLUM, V7, P406, DOI 10.1007/s12311-008-0043-y
Williams BL, 2007, J VIROL, V81, P2675, DOI 10.1128/JVI.02245-06
Williams DL, 2006, NEUROPSYCHOLOGY, V20, P21, DOI 10.1037/0894-4105.20.1.21
Williams K, 2010, COCHRANE DB SYST REV, V4
Wills S, 2009, BRAIN BEHAV IMMUN, V23, P64, DOI 10.1016/j.bbi.2008.07.007
Wills S, 2011, MOL AUTISM, V2, DOI 10.1186/2040-2392-2-5
Winslow JT, 2004, CURR OPIN NEUROBIOL, V14, P248, DOI 10.1016/j.conb.2004.03.009
Yip J, 2007, ACTA NEUROPATHOL, V113, P559, DOI 10.1007/s00401-006-0176-3
Yip J, 2009, AUTISM RES, V2, P50, DOI 10.1002/aur.62
Yuste R, 2005, NAT REV NEUROSCI, V6, P477, DOI 10.1038/nrn1686
Zilbovicius M, 2000, AM J PSYCHIAT, V157, P1988, DOI 10.1176/appi.ajp.157.12.1988
Zuo J, 1997, NATURE, V388, P769
NR 310
TC 75
Z9 76
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1473-4222
EI 1473-4230
J9 CEREBELLUM
JI Cerebellum
PD SEP
PY 2012
VL 11
IS 3
BP 777
EP 807
DI 10.1007/s12311-012-0355-9
PG 31
WC Neurosciences
SC Neurosciences & Neurology
GA 985SX
UT WOS:000307291500017
PM 22370873
ER
PT J
AU Naeem, M
Prasad, G
Watson, DR
Kelso, JAS
AF Naeem, Muhammad
Prasad, Girijesh
Watson, David R.
Kelso, J. A. Scott
TI Functional dissociation of brain rhythms in social coordination
SO CLINICAL NEUROPHYSIOLOGY
LA English
DT Article
DE Upper and lower mu; Social-coordination; Imitation; Hemisphere
asymmetry; De-/synchronization; Synchronization index (SI)
ID COGNITIVE MOTOR CONTROL; MU-RHYTHMS; DESYNCHRONIZATION ERD; NEURAL
MECHANISMS; EEG ALPHA; IMITATION; DYNAMICS; OSCILLATIONS; FREQUENCY;
MOVEMENT
AB Objectives: The goal of this research was to investigate sub-band modulations in the mu domain in dyads performing different social coordination tasks.
Methods: Dyads of subjects performed rhythmic finger movement under three different task conditions: intrinsic - maintain self-produced movement while ignoring their partner's movement; in-phase - synchronize with partner; and anti-phase - maintain syncopation with partner. Movement profiles of the dyads were used to estimate a synchronization index (SI) to verify differences in coordination according to each task. EEG was recorded during task performance and at baseline (partner's actions hidden from view). Log power ratios of mu band activity (active against baseline) were used to assess the relative levels of synchronization/de-synchronization in both the upper and lower mu bands.
Results: Results confirm a functional dissociation of lower (8-10 Hz) and upper (10-12 Hz) mu bands in social coordination tasks. Lower mu band activity was independent of specific modulations across tasks and hemispheric preferences. Upper mu band activity was sensitive to coordination tasks and exhibited marked differences between the hemispheres. Accentuated de-synchronization of right relative to left hemisphere in the anti-phase task appeared related to the greater demand of perceptual-motor discrimination. Left hemisphere de-synchronization in both in-phase and anti-phase coordination was interpreted in terms of successful production of imitation. Right hemisphere synchronization in the intrinsic task was interpreted as inhibition of an imitative response tendency.
Conclusions: Functional dissociation of lower and upper mu band and hemispheric preferences exists in real-time social coordination.
Significance: This research attests to the merit of analyzing sub-band activity in the alpha-mu domain in order to identify neural correlates of social coordination. Such 'neuromarkers' may be relevant for brain disorders such as apraxia and autism. (C) 2012 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.
C1 [Naeem, Muhammad; Prasad, Girijesh; Watson, David R.; Kelso, J. A. Scott] Univ Ulster, Intelligent Syst Res Ctr, Sch Comp & Intelligent Syst, Londonderry BT48 7JL, North Ireland.
[Kelso, J. A. Scott] Florida Atlantic Univ, Ctr Complex Syst & Brain Sci, Human Brain & Behav Lab, Boca Raton, FL 33431 USA.
RP Naeem, M (reprint author), Univ Ulster, Intelligent Syst Res Ctr, Sch Comp & Intelligent Syst, Magee Campus, Londonderry BT48 7JL, North Ireland.
EM m.naeem@ulster.ac.uk
FU NIMH [MH080838]; NSF [BCS0826897]; US ONR [N000140510117]; Department of
Education and Learning Northern Ireland
FX This work was funded by NIMH Grant MH080838, NSF Grant BCS0826897, and
the US ONR N000140510117 (JASK) and Department of Education and Learning
Northern Ireland under the cross-border program for collaborative
research (MN, GP and DW).
CR Babiloni C, 1999, NEUROIMAGE, V10, P658, DOI 10.1006/nimg.1999.0504
Brass M, 2003, NEUROPSYCHOLOGY, V17, P265, DOI 10.1037/0894-4105.17.2.265
Brass M, 2005, NEUROPSYCHOLOGIA, V43, P89, DOI 10.1016/j.neuropsychologia.2004.06.018
Bryce D, 2011, NEUROIMAGE, V57, P671, DOI 10.1016/j.neuroimage.2010.12.006
Chatrian G. E., 1985, American Journal of EEG Technology, V25
DAWSON G, 1985, PSYCHOPHYSIOLOGY, V22, P237, DOI 10.1111/j.1469-8986.1985.tb01593.x
Decety J, 2002, NEUROIMAGE, V15, P265, DOI 10.1006/nimg.2001.0938
Della Sala S, 2006, NEUROPSYCHOLOGIA, V44, P1496, DOI 10.1016/j.neuropsychologia.2005.11.011
Georgopoulos AP, 2002, CURR OPIN NEUROBIOL, V12, P678, DOI 10.1016/S0959-4388(02)00382-3
Georgopoulos AP, 2000, CURR OPIN NEUROBIOL, V10, P238, DOI 10.1016/S0959-4388(00)00072-6
Goldenberg G, 2001, NEUROPSYCHOLOGIA, V39, P1432, DOI 10.1016/S0028-3932(01)00062-8
Goldenberg G, 2002, NEUROLOGY, V59, P893
Iacoboni M, 2005, CURR OPIN NEUROBIOL, V15, P632, DOI 10.1016/j.conb.2005.10.010
Iacoboni M, 1999, SCIENCE, V286, P2526, DOI 10.1126/science.286.5449.2526
Jantzen KJ, 2001, CLIN NEUROPHYSIOL, V112, P1685, DOI 10.1016/S1388-2457(01)00626-5
Kelso JAS, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0005749
Kelso J. A. S., 1995, DYNAMIC PATTERNS SEL
Kelso JAS, 2001, P ROY SOC B-BIOL SCI, V268, P1207
KELSO JAS, 1990, ATTENTION PERFORM, V8, P139
KELSO JAS, 1992, J EXP PSYCHOL GEN, V121, P260, DOI 10.1037/0096-3445.121.3.260
KELSO JAS, 1981, J MOTOR BEHAV, V13, P226
Kelso J.A.S., 1984, AM J PHYSIOL-REG I, V246, pR1000
Kelso S. J. A., 2009, ENCY COMPLEXITY SYST, P8198, DOI DOI 10.1007/978-0-387-30440-3_486
Kilner JM, 2008, CURR BIOL, V18, pR32, DOI 10.1016/j.cub.2007.11.008
Klimesch W, 1998, EVOKED POTENTIAL, V108, P123, DOI 10.1016/S0168-5597(97)00078-6
KLIMESCH W, 1992, J PSYCHOPHYSIOL, V6, P185
Klimesch W, 1999, BRAIN RES REV, V29, P169, DOI 10.1016/S0165-0173(98)00056-3
Lopes da Silva F.H, 1993, ELECTROENCEPHALOGRAP, P63
Marshall PJ, 2009, NEUROPSYCHOLOGIA, V47, P2100, DOI 10.1016/j.neuropsychologia.2009.03.022
Matousek M., 1973, AUTOMATION CLIN ELEC, P75
Mayville JM, 2002, HUM BRAIN MAPP, V17, P214, DOI 10.1002/hbm.10065
Muhlau M, 2005, NEUROPSYCHOLOGIA, V43, P1086, DOI 10.1016/j.neuropsychologia.2004.10.004
Oullier O, 2008, IEEE T NEUR SYS REH, V16, P557, DOI 10.1109/TNSRE.2008.2009960
Oullier O, 2008, SOC NEUROSCI, V3, P178, DOI 10.1080/17470910701563392
Perry A, 2009, BRAIN RES, V1282, P126, DOI 10.1016/j.brainres.2009.05.059
PFURTSCHELLER G, 1989, J CLIN NEUROPHYSIOL, V6, P75, DOI 10.1097/00004691-198901000-00003
Pfurtscheller G, 2003, EPILEPSIA, V44, P2, DOI 10.1111/j.0013-9580.2003.12001.x
Pfurtscheller G, 2000, CLIN NEUROPHYSIOL, V111, P1873, DOI 10.1016/S1388-2457(00)00428-4
Pineda JA, 2009, BIOL PSYCHOL, V80, P306, DOI 10.1016/j.biopsycho.2008.11.003
Pineda JA, 2005, BRAIN RES REV, V50, P57, DOI 10.1016/j.brainresrev.2005.04.005
RAY WJ, 1985, INT J PSYCHOPHYSIOL, V3, P43, DOI 10.1016/0167-8760(85)90018-2
Rizzolatti G, 2001, NEURON, V31, P889, DOI 10.1016/S0896-6273(01)00423-8
Schmidt RC, 2008, UND COM SYS, P281, DOI 10.1007/978-3-540-74479-5_14
Schmidt RC, 1997, ECOL PSYCHOL, V9, P189, DOI 10.1207/s15326969eco0903_2
Tognoli E, 2007, SOC NEUROSCI, V304, p24/
Tognoli E, 2007, P NATL ACAD SCI USA, V104, P8190, DOI 10.1073/pnas.0611453104
Ulloa ER, 2007, BEHAV BRAIN RES, V183, P188, DOI 10.1016/j.bbr.2007.06.007
Zhuang P, 1997, ELECTROEN CLIN NEURO, V102, P374, DOI 10.1016/S0013-4694(96)96030-7
NR 48
TC 7
Z9 8
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
IRELAND
SN 1388-2457
J9 CLIN NEUROPHYSIOL
JI Clin. Neurophysiol.
PD SEP
PY 2012
VL 123
IS 9
BP 1789
EP 1797
DI 10.1016/j.clinph.2012.02.065
PG 9
WC Clinical Neurology; Neurosciences
SC Neurosciences & Neurology
GA 984IR
UT WOS:000307183800020
PM 22425484
ER
PT J
AU Mathewson, KJ
Jetha, MK
Drmic, IE
Bryson, SE
Goldberg, JO
Schmidt, LA
AF Mathewson, Karen J.
Jetha, Michelle K.
Drmic, Irene E.
Bryson, Susan E.
Goldberg, Joel O.
Schmidt, Louis A.
TI Regional EEG alpha power, coherence, and behavioral symptomatology in
autism spectrum disorder
SO CLINICAL NEUROPHYSIOLOGY
LA English
DT Article
DE Autism spectrum disorder; Perceptual processing; EEG Alpha frequency;
EEG coherence
ID MILD COGNITIVE IMPAIRMENT; HIGH-FUNCTIONING AUTISM; ALZHEIMERS-DISEASE;
INHIBITORY CONTROL; FRONTAL-CORTEX; BRAIN ACTIVITY; DEFAULT MODE;
CORTICAL CONNECTIVITY; SPATIAL ATTENTION; INFANTILE-AUTISM
AB Objective: Although distinct patterns of resting brain electrical activity (EEG) and functional connectivity are believed to distinguish individuals with autism spectrum disorders (ASD) from their unimpaired peers, researchers have only recently begun to link patterns of brain activity and connectivity to behavior in ASD.
Method: We examined regional eyes-closed and eyes-open EEG alpha power and coherence at rest in relation to self-reported perceptual and social behavior in 15 adults diagnosed with ASD and a matched comparison group of 16 unimpaired adults.
Results: The groups did not differ on eyes-closed EEG alpha power or coherence, but adults with ASD showed less alpha suppression for the eyes-open condition than did controls. In the ASD group, preferential attention to detail (perceptual domain) was associated with lower levels of alpha activity and reduced coherence in posterior regions. No relations between social interaction difficulties (social domain) and alpha measures were found for either group alone.
Conclusions: These relations suggest that the processing of perceptual details may be carried out by relatively less synchronized neuronal units in adults with ASD, and may be relatively automatic.
Significance: Findings are discussed in relation to recent models of narrow minicolumnar brain structure and reduced functional neural connectivity in ASD. (C) 2012 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.
C1 [Mathewson, Karen J.; Jetha, Michelle K.; Schmidt, Louis A.] McMaster Univ, Dept Psychol Neurosci & Behav, Hamilton, ON L8S 4K1, Canada.
[Goldberg, Joel O.] York Univ, Dept Psychol, Toronto, ON M3J 2R7, Canada.
[Bryson, Susan E.] Dalhousie Univ, Halifax, NS, Canada.
[Bryson, Susan E.] IWK Hlth Ctr, Dept Pediat & Psychol, Halifax, NS, Canada.
[Drmic, Irene E.; Goldberg, Joel O.] McMaster Univ, Dept Psychiat & Behav Neurosci, Hamilton, ON L8S 4K1, Canada.
RP Mathewson, KJ (reprint author), McMaster Univ, Dept Psychol Neurosci & Behav, Hamilton, ON L8S 4K1, Canada.
EM mathewkj@mcmaster.ca; schmidtl@mcmaster.ca
FU Lawson Foundation; Natural Sciences and Engineering Research Council of
Canada (NSERC); National Alliance for Autism Research (NAAR); Community
Social and Vocational Rehabilitation (CVSR) Foundation; Social Sciences
and Humanities Research Council of Canada (SSHRC); NSERC
FX The second author is now at the Department of Psychology, Brock
University, and the third author is now a post-doctoral fellow at Offord
Centre for Child Studies in Hamilton, Ontario. This research was
supported by a Lawson Foundation Post-doctoral Fellowship awarded to the
first author under the direction of LAS, a Natural Sciences and
Engineering Research Council of Canada (NSERC) Pre-doctoral Fellowship
awarded to the second author under the direction of LAS, a National
Alliance for Autism Research (NAAR) Pre-doctoral Fellowship awarded to
the third author under the direction of SEB, a Community Social and
Vocational Rehabilitation (CVSR) Foundation grant awarded to JOG, and a
Social Sciences and Humanities Research Council of Canada (SSHRC) and
NSERC operating grants awarded to LAS. The authors would like to thank
Sue McKee and Stephanie Tak for their help with data collection, Drs.
Ingmar Gutberlet and Jose Muradas at BVA for their kind and invaluable
assistance with technical questions, and the clients and staff at the
independent living program.
CR Alfimova M V, 2008, Neurosci Behav Physiol, V38, P533, DOI 10.1007/s11055-008-9013-6
American Psychiatric Association, 2000, DIAGN STAT MAN MENT
Anagnostou E, 2011, MOL AUTISM, V2, DOI 10.1186/2040-2392-2-4
Babiloni C, 2007, EUR J NEUROSCI, V25, P3742, DOI 10.1111/j.1460-9568.2007.05601.x
Baron-Cohen S, 2001, J AUTISM DEV DISORD, V31, P5, DOI 10.1023/A:1005653411471
Basar E, 2001, INT J PSYCHOPHYSIOL, V39, P241, DOI 10.1016/S0167-8760(00)00145-8
Belmonte MK, 2004, J NEUROSCI, V24, P9228, DOI 10.1523/JNEUROSCI.3340-04.2004
BESTHORN C, 1994, ELECTROEN CLIN NEURO, V90, P242, DOI 10.1016/0013-4694(94)90095-7
Brown C, 2005, CORTEX, V41, P364, DOI 10.1016/S0010-9452(08)70273-9
Buckner RL, 2007, NEUROIMAGE, V37, P1091, DOI 10.1016/j.neuroimage.2007.01.010
Buxhoeveden DP, 2006, NEUROPATH APPL NEURO, V32, P483, DOI 10.1111/j.1365-2990.2006.00745.x
CANTOR DS, 1986, J AUTISM DEV DISORD, V16, P169, DOI 10.1007/BF01531728
Casanova MF, 2009, PHILOS T R SOC B, V364, P1433, DOI 10.1098/rstb.2008.0331
Casanova MF, 2002, NEUROLOGY, V58, P428
Casanova MF, 2003, NEUROSCIENTIST, V9, P496, DOI 10.1177/1073858403253552
Casanova MF, 2006, ACTA NEUROPATHOL, V112, P287, DOI 10.1007/s00401-006-0085-5
Castelli F, 2002, BRAIN, V125, P1839, DOI 10.1093/brain/awf189
Chan AS, 2006, J CHILD NEUROL, V21, P391
Cherkassky VL, 2006, NEUROREPORT, V17, P1687, DOI 10.1097/01.wnr.0000239956.45448.4c
Coben R, 2008, CLIN NEUROPHYSIOL, V119, P1002, DOI 10.1016/j.clinph.2008.01.013
COHEN IL, 1994, BIOL PSYCHIAT, V36, P5, DOI 10.1016/0006-3223(94)90057-4
Corbetta M, 2002, NAT REV NEUROSCI, V3, P201, DOI 10.1038/nrn755
COURCHESNE E, 1993, AM J ROENTGENOL, V160, P387
Courchesne E, 2005, CURR OPIN NEUROBIOL, V15, P225, DOI 10.1016/j.conb.2005.03.001
Courchesne E, 1994, BEHAV NEUROSCI, V108, P8484
Daoust AM, 2008, PSYCHOPHYSIOLOGY, V45, P299, DOI 10.1111/j.1469-8986.2007.00626.x
DAWSON G, 1995, J ABNORM CHILD PSYCH, V23, P569, DOI 10.1007/BF01447662
De Luca M, 2006, NEUROIMAGE, V29, P1359, DOI 10.1016/j.neuroimage.2005.08.035
DUFFY FH, 1984, ANN NEUROL, V16, P430, DOI 10.1002/ana.410160403
Ergenoglu T, 2004, COGNITIVE BRAIN RES, V20, P376, DOI 10.1016/j.cogbrainres.2004.03.009
Fingelkurts AA, 2005, NEUROSCI BIOBEHAV R, V28, P827, DOI 10.1016/j.neubiorev.2004.10.009
Freeman WJ, 2000, NEURAL NETWORKS, V13, P11, DOI 10.1016/S0893-6080(99)00093-3
Freeman WJ, 2001, BIOSYSTEMS, V59, P109, DOI 10.1016/S0303-2647(00)00146-5
FRENCH CC, 1984, INT J PSYCHOPHYSIOL, V1, P241, DOI 10.1016/0167-8760(84)90044-8
Friston Karl J., 1994, Human Brain Mapping, V2, P56, DOI 10.1002/hbm.460020107
FULLER PW, 1978, J LEARN DISABIL, V11, P303
Goldman RI, 2002, NEUROREPORT, V13, P2487, DOI 10.1097/00001756-200212200-00022
Gottlieb J, 2007, NEURON, V53, P9, DOI 10.1016/j.neuron.2006.12.009
Greicius MD, 2003, P NATL ACAD SCI USA, V100, P253, DOI 10.1073/pnas.0135058100
Greicius MD, 2009, CEREB CORTEX, V19, P72, DOI 10.1093/cercor/bhn059
Grosse P, 2002, CLIN NEUROPHYSIOL, V113, P1523, DOI 10.1016/S1388-2457(02)00223-7
Guntekin B, 2010, COGN NEURODYNAMICS, V4, P107, DOI 10.1007/s11571-010-9106-0
Gustafsson L, 1997, BIOL PSYCHIAT, V42, P1138, DOI 10.1016/S0006-3223(97)00141-8
Haist F, 2005, DEV NEUROPSYCHOL, V27, P425, DOI 10.1207/s15326942dn2703_7
Hanslmayr S, 2005, NEUROSCI LETT, V375, P64, DOI 10.1016/j.neulet.2004.10.092
Hanslmayr S, 2007, NEUROIMAGE, V37, P1465, DOI 10.1016/j.neuroimage.2007.07.011
Hoekstra RA, 2008, J AUTISM DEV DISORD, V38, P1555, DOI 10.1007/s10803-008-0538-x
Hummel F, 2002, BRAIN, V125, P404, DOI 10.1093/brain/awf030
Ito Y, 1998, J NEUROPSYCH CLIN N, V10, P298
Jasper H. H., 1958, ELECTROENCEPHALOGRAP, V10, P371, DOI DOI 10.1016/0013-4694(58)90053-1
Jelic V, 2000, NEUROBIOL AGING, V21, P533, DOI 10.1016/S0197-4580(00)00153-6
Just MA, 2007, CEREB CORTEX, V17, P951, DOI 10.1093/cercor/bhl006
Just MA, 2004, BRAIN, V127, P1811, DOI 10.1093/brain/awh199
Kana RK, 2007, BIOL PSYCHIAT, V62, P198, DOI 10.1016/j.biopsych.2006.08.004
Kennedy DP, 2006, P NATL ACAD SCI USA, V103, P8275, DOI 10.1073/pnas.0600674103
Kennedy DP, 2008, SOC COGN AFFECT NEUR, V3, P177, DOI 10.1093/scan/nsn011
Klimesch W, 2003, EUR J NEUROSCI, V17, P1129, DOI 10.1046/j.1460-9568.2003.02517.x
Klimesch W, 2007, BRAIN RES REV, V53, P63, DOI 10.1016/j.brainresrev.2006.06.003
Klimesch W, 1999, BRAIN RES REV, V29, P169, DOI 10.1016/S0165-0173(98)00056-3
Knyazev GG, 2006, INT J PSYCHOPHYSIOL, V59, P151, DOI 10.1016/j.ijpsycho.2005.03.025
Knyazev GG, 2007, NEUROSCI BIOBEHAV R, V31, P377, DOI 10.1016/j.neubiorev.2006.10.004
Lachaux JP, 1999, HUM BRAIN MAPP, V8, P194, DOI 10.1002/(SICI)1097-0193(1999)8:4<194::AID-HBM4>3.0.CO;2-C
LORD C, 1989, J AUTISM DEV DISORD, V19, P185, DOI 10.1007/BF02211841
LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
Mathewson KE, 2009, J NEUROSCI, V29, P2725, DOI 10.1523/JNEUROSCI.3963-08.2009
Merriam EP, 2003, NEURON, V39, P361, DOI 10.1016/S0896-6273(03)00393-3
Minshew NJ, 2007, ARCH NEUROL-CHICAGO, V64, P945, DOI 10.1001/archneur.64.7.945
Monk CS, 2009, NEUROIMAGE, V47, P764, DOI 10.1016/j.neuroimage.2009.04.069
Mottron L, 2006, J AUTISM DEV DISORD, V36, P27, DOI 10.1007/s10803-005-0040-7
Mottron L, 2009, PHILOS T R SOC B, V364, P1385, DOI 10.1098/rstb.2008.0333
Mountcastle VB, 1997, BRAIN, V120, P701, DOI 10.1093/brain/120.4.701
Murias M, 2007, BIOL PSYCHIAT, V62, P270, DOI 10.1016/j.biopsych.2006.11.012
Neuper C, 2001, INT J PSYCHOPHYSIOL, V43, P41, DOI 10.1016/S0167-8760(01)00178-7
Neuper C, 2006, PROG BRAIN RES, V159, P211, DOI 10.1016/S0079-6123(06)59014-4
Noonan SK, 2009, BRAIN RES, V1262, P48, DOI 10.1016/j.brainres.2008.12.076
Nunez P.L., 1995, NEOCORTICAL DYNAMICS
OGAWA T, 1982, BRAIN DEV-JPN, V4, P439
OLDFIELD RC, 1971, NEUROPSYCHOLOGIA, V9, P97, DOI 10.1016/0028-3932(71)90067-4
Perreault A, 2011, PLOS ONE, V6, P1
PFURTSCHELLER G, 1992, ELECTROEN CLIN NEURO, V83, P62, DOI 10.1016/0013-4694(92)90133-3
Raichle ME, 2006, ANNU REV NEUROSCI, V29, P449, DOI 10.1146/annurev.neuro.29.051605.112819
Raichle ME, 2001, P NATL ACAD SCI USA, V98, P676, DOI 10.1073/pnas.98.2.676
Rihs TA, 2007, EUR J NEUROSCI, V25, P603, DOI 10.1111/j.1460-9568.2007.05278.x
Rippon G, 2007, INT J PSYCHOPHYSIOL, V63, P164, DOI 10.1016/j.ijpsycho.2006.03.012
Roid G. H., 2003, STANFORD BINET INTEL
Rubenstein JLR, 2003, GENES BRAIN BEHAV, V2, P255, DOI 10.1046/j.1601-183X.2003.00037.x
Sauseng P, 2008, NEUROSCI BIOBEHAV R, V32, P1001, DOI 10.1016/j.neubiorev.2008.03.014
Sauseng P, 2009, NEUROPSYCHOLOGIA, V47, P284, DOI 10.1016/j.neuropsychologia.2008.07.021
Seeley WW, 2007, J NEUROSCI, V27, P2349, DOI 10.1523/JNEUROSCI.5587-06.2007
SHERIDAN PH, 1988, NEUROLOGY, V38, P747
Sporns O., 2011, NETWORKS BRAIN
Srinivasan K, 1998, IEEE T BIOMED ENG, V45, P814
THATCHER RW, 1986, ELECTROEN CLIN NEURO, V64, P123, DOI 10.1016/0013-4694(86)90107-0
Thatcher RW, 2005, CLIN NEUROPHYSIOL, V116, P2129, DOI 10.1016/j.clinph.2005.04.026
Thut G, 2006, J NEUROSCI, V26, P9494, DOI 10.1523/JNEUROSCI.0875-06.2006
Tommerdahl M, 2008, BEHAV BRAIN FUNCT, V4, DOI 10.1186/1744-9081-4-19
Towers DN, 2009, PSYCHOPHYSIOLOGY, V46, P132, DOI 10.1111/j.1469-8986.2008.00759.x
Varela F, 2001, NAT REV NEUROSCI, V2, P229, DOI 10.1038/35067550
Villalobos ME, 2005, NEUROIMAGE, V25, P916, DOI 10.1016/j.neuroimage.2004.12.022
von Stein A, 2000, INT J PSYCHOPHYSIOL, V38, P301, DOI 10.1016/S0167-8760(00)00172-0
Waterhouse L, 1996, PSYCHOL REV, V103, P457, DOI 10.1037/0033-295X.103.3.457
Weng SJ, 2010, BRAIN RES, V1313, P202, DOI 10.1016/j.brainres.2009.11.057
Wilson TW, 2007, BIOL PSYCHIAT, V62, P192, DOI 10.1016/j.biopsych.2007.07.002
Wouters SGM, 2011, RES AUTISM SPECT DIS, V5, P1169, DOI 10.1016/j.rasd.2011.01.002
NR 104
TC 17
Z9 17
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
IRELAND
SN 1388-2457
J9 CLIN NEUROPHYSIOL
JI Clin. Neurophysiol.
PD SEP
PY 2012
VL 123
IS 9
BP 1798
EP 1809
DI 10.1016/j.clinph.2012.02.061
PG 12
WC Clinical Neurology; Neurosciences
SC Neurosciences & Neurology
GA 984IR
UT WOS:000307183800021
PM 22405935
ER
PT J
AU Juhasz, C
Chugani, DC
Barger, GR
Kupsky, WJ
Chakraborty, PK
Muzik, O
Mittal, S
AF Juhasz, Csaba
Chugani, Diane C.
Barger, Geoffrey R.
Kupsky, William J.
Chakraborty, Pulak K.
Muzik, Otto
Mittal, Sandeep
TI Quantitative PET Imaging of Tryptophan Accumulation in Gliomas and
Remote Cortex: Correlation With Tumor Proliferative Activity
SO CLINICAL NUCLEAR MEDICINE
LA English
DT Article
DE tryptophan; glioma; Ki-67 labeling index; kynurenine; PET; serotonin
ID BRAIN-SEROTONIN SYNTHESIS; POSITRON-EMISSION-TOMOGRAPHY; INDOLEAMINE
2,3-DIOXYGENASE; IN-VIVO; DEPRESSION; METABOLISM; KYNURENINE; GRADE;
DEGRADATION; TRANSPORT
AB Purpose: PET studies with alpha[C-11]methyl-L-tryptophan (AMT) have shown decreased serotonin synthesis based on a decrease of the unidirectional uptake rate (K-complex) in neuropsychiatric conditions such as autism and depression. Increased AMT K-complex in tumors can indicate increased tryptophan metabolism via the immunosuppressive kynurenine pathway. Moreover, apparent AMT volume of distribution (VD') reflects net tryptophan transport from blood to tissue. We evaluated if kinetic parameters (K-complex, VD') of AMT, measured by PET, can predict the proliferative activity of glioma, and if these AMT parameters are altered in the remote cortex.
Methods: We evaluated dynamic AMT PET images of 30 adult patients with grade 2 to 4 gliomas according to the World Health Organization's classification to determine tumoral AMT VD' and K-complex values, which were correlated with tumor proliferative activity as assessed by the Ki-67 labeling index in resected tumor specimens. We also compared cortical VD' and K-complex values between patients with glioma and healthy controls.
Results: Both VD' and K-complex values were significantly higher in gliomas than in the contralateral cortex (VD', P < 0.001; K-complex, P < 0.001). Tumoral VD' values and tumor/cortex VD' ratios, but not the K-complex, showed strong positive correlations with the proliferative activity of glioma (P <= 0.001). The contralateral frontal cortex showed decreased AMT VD' and K-complex in patients with glioma compared with those in controls (P <= 0.01).
Conclusions: Increased net amino acid transport into tumor tissue, quantified by PET, can serve as an imaging marker of the proliferative activity of glioma. The data also suggest a glioma-induced down-regulation of cortical serotonin synthesis, likely mediated by shunting of tryptophan from serotonin synthesis to kynurenine metabolism.
C1 [Juhasz, Csaba] Wayne State Univ, Sch Med, Dept Neurol, Detroit, MI 48201 USA.
[Juhasz, Csaba; Chugani, Diane C.; Muzik, Otto] Wayne State Univ, Dept Pediat, Detroit, MI 48201 USA.
[Juhasz, Csaba; Chugani, Diane C.; Chakraborty, Pulak K.; Muzik, Otto] Childrens Hosp Michigan, PET Ctr, Detroit, MI 48201 USA.
[Juhasz, Csaba; Chugani, Diane C.; Chakraborty, Pulak K.; Muzik, Otto] Childrens Hosp Michigan, Translat Imaging Lab, Detroit, MI 48201 USA.
[Juhasz, Csaba; Barger, Geoffrey R.; Kupsky, William J.; Mittal, Sandeep] Wayne State Univ, Karmanos Canc Inst, Detroit, MI 48201 USA.
[Kupsky, William J.] Wayne State Univ, Dept Pathol, Detroit, MI 48201 USA.
[Chakraborty, Pulak K.; Muzik, Otto] Wayne State Univ, Dept Radiol, Detroit, MI 48201 USA.
[Mittal, Sandeep] Wayne State Univ, Dept Neurosurg, Detroit, MI 48201 USA.
RP Juhasz, C (reprint author), Wayne State Univ, Sch Med, Dept Neurol, 3901 Beaubien St, Detroit, MI 48201 USA.
EM juhasz@pet.wayne.edu
FU National Cancer Institute [CA123451]
FX The study was supported by a grant (CA123451 to C.J.) from the National
Cancer Institute. The authors declare that they have no conflict of
interest.
CR Alkonyi B, 2012, J NEURO-ONCOL, V107, P365, DOI 10.1007/s11060-011-0750-y
Backes H, 2009, EUR J NUCL MED MOL I, V36, P1960, DOI 10.1007/s00259-009-1244-4
Batista CEA, 2009, MOL IMAGING BIOL, V11, P460, DOI 10.1007/s11307-009-0225-0
Chugani DC, 1997, ANN NEUROL, V42, P666, DOI 10.1002/ana.410420420
Chugani DC, 2000, J CEREBR BLOOD F MET, V20, P2, DOI 10.1097/00004647-200001000-00002
DIKSIC M, 1990, J CEREBR BLOOD F MET, V10, P1
Fueger BJ, 2010, J NUCL MED, V51, P1532, DOI 10.2967/jnumed.110.078592
Guillevin R, 2008, J NEURO-ONCOL, V87, P181, DOI 10.1007/s11060-007-9508-y
Iwami K, 2011, NEUROSURG REV, V34, P253, DOI 10.1007/s10143-011-0320-y
Johannessen AL, 2006, PATHOL ONCOL RES, V12, P143
Juhasz C, 2006, J CEREBR BLOOD F MET, V26, P345, DOI 10.1038/sj.jcbfm.9600199
Juhasz C, 2009, J NUCL MED, V50, P356, DOI 10.2967/jnumed.108.058776
Juhasz C, 2011, J NEURO-ONCOL, V102, P409, DOI 10.1007/s11060-010-0327-1
Kim S, 2005, EUR J NUCL MED MOL I, V32, P52, DOI 10.1007/s00259-004-1598-6
Kobayashi K, 2008, NEUROSURGERY, V62, P493, DOI [10.1227/01.neu.0000316018.51292.19, 10.1227/01.NEU.0000255470.75752.02]
Kotsarini C, 2010, NEUROSURGERY, V67, P1799, DOI 10.1227/NEU.0b013e3181fa775b
Kurz K, 2011, CURR OPIN CLIN NUTR, V14, P49, DOI 10.1097/MCO.0b013e328340d849
LAPIN IP, 1969, LANCET, V1, P132
Leyton M, 2001, AM J PSYCHIAT, V158, P775, DOI 10.1176/appi.ajp.158.5.775
Litofsky NS, 2009, J NEURO-ONCOL, V94, P153, DOI 10.1007/s11060-009-9825-4
Mainio A, 2005, J NEUROSURG, V103, P841, DOI 10.3171/jns.2005.103.5.0841
Mandi Y, 2012, J NEURAL TRANSM, V119, P197, DOI 10.1007/s00702-011-0681-y
Mangoni A, 1974, Adv Biochem Psychopharmacol, V11, P293
Miura H, 2008, STRESS, V11, P198, DOI 10.1080/10253890701754068
Miyazaki T, 2009, J NEUROSURG, V111, P230, DOI 10.3171/2008.10.JNS081141
Munn DH, 2007, J CLIN INVEST, V117, P1147, DOI 10.1172/JCI31178
Muzik O, 1997, J CEREBR BLOOD F MET, V17, P659
Nawashiro Hiroshi, 2005, Brain Tumor Pathol, V22, P89, DOI 10.1007/s10014-005-0188-z
Sperner-Unterweger B, 2011, IMMUNOBIOLOGY, V216, P296, DOI 10.1016/j.imbio.2010.07.010
Nishikawa M, 2009, ALCOHOL CLIN EXP RES, V33, P233, DOI 10.1111/j.1530-0277.2008.00820.x
Okita Y, 2010, NEUROIMAGE, V49, P2977, DOI 10.1016/j.neuroimage.2009.11.024
Oxenkrug GF, 2010, ISR J PSYCHIATR REL, V47, P56
PARDRIDGE WM, 1990, J NEUROCHEM, V54, P971, DOI 10.1111/j.1471-4159.1990.tb02345.x
PATLAK CS, 1983, J CEREBR BLOOD F MET, V3, P1
Rooney AG, 2011, J NATL CANCER I, V103, P61, DOI 10.1093/jnci/djq458
Rosa-Neto P, 2004, ARCH GEN PSYCHIAT, V61, P556, DOI 10.1001/archpsyc.61.6.556
Suzuki Y, 2010, LUNG CANCER, V67, P361, DOI 10.1016/j.lungcan.2009.05.001
Ullrich R, 2008, CLIN CANCER RES, V14, P2049, DOI 10.1158/1078-0432.CCR-07-1553
Uyttenhove C, 2003, NAT MED, V9, P1269, DOI 10.1038/nm934
Young SN, 1999, ADV EXP MED BIOL, V467, P11
NR 40
TC 5
Z9 5
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0363-9762
J9 CLIN NUCL MED
JI Clin. Nucl. Med.
PD SEP
PY 2012
VL 37
IS 9
BP 838
EP 842
DI 10.1097/RLU.0b013e318251e458
PG 5
WC Radiology, Nuclear Medicine & Medical Imaging
SC Radiology, Nuclear Medicine & Medical Imaging
GA 992VL
UT WOS:000307808000011
PM 22889771
ER
PT J
AU Koller, HP
AF Koller, Harold P.
TI Visual processing and learning disorders
SO CURRENT OPINION IN OPHTHALMOLOGY
LA English
DT Review
DE attention deficit/hyperactive disorder; autism spectrum
disorders/pervasive developmental disorder; dyslexia; nonverbal learning
disorder; visual and auditory processing/learning disorders
ID AUTISM SPECTRUM DISORDERS; ATTENTION-DEFICIT; CHILDREN; DISABILITIES;
DYSLEXIA; INTERVENTIONS
AB Purpose of review
Many children are seen by ophthalmologists because of scholastic difficulties in school initially attributed to eyesight when, in fact, the problem often is a result of a disorder of the brain processing vision. A number of neuropsychological conditions predisposing and affecting children with learning disorders will be described. Visual processing is the main brain function allowing normal perception of what is being viewed. Ophthalmologists as well as patients must realize that with normal 20/20 eyesight interpretation of what is seen may be dysfunctional because of faulty brain processing of that which is seen by normal eyes. Abnormal Visual Processing as well as auditory processing disorders eventually lead directly to learning disorders in children and young adults.
Recent findings
New Clinical Practice Guidelines for the diagnosis, evaluation and treatment of children with attention deficit disorder (ADD)/attention deficit hyperactive disorder (ADHD) have been established by the American Academy of Pediatrics. An overgrowth of neurons in the prefrontal cortex of children with autism has recently been discovered. Six out of 1000 children have been reported as having Pervasive Developmental Disorder (PDD), which is another name for Autism Spectrum Disorder (ASD). A number of alternative treatments for ASD have recently been published. The families of autistic children have increased emotional and financial burdens, often affecting the workplace.
Summary
Recent neuropsychology discoveries have helped in the prevention, evaluation and treatment of children with visual processing and learning disorders. Quality-of-life and educational efficiency therefore can be improved.
C1 Wills Eye Inst, Dept Pediat Ophthalmol Strabismus & Genet, Philadelphia, PA 19107 USA.
RP Koller, HP (reprint author), Wills Eye Inst, Dept Pediat Ophthalmol Strabismus & Genet, 840 Walnut St, Philadelphia, PA 19107 USA.
EM cyanderman@verizon.net
CR ADHD, 2011, AM ACAD PEDIAT, V28, P1007
American Psychiatric Association, 1995, DIAGN STAT MAN MENT
[Anonymous], 2009, LEARN DIS DYSL VIS
Arcari K, 2005, SIMILARITIES DIFFERE
Baron-Cohen S, 2003, ASPERGERS SYNDROME E, P135
Baron-Cohen S, 2011, PLOS BIOL, V9, DOI 10.1371/journal.pbio.1001081
Bohlander AJ, 2012, PEDIATR CLIN N AM, V59, P165, DOI 10.1016/j.pcl.2011.10.001
Cidav Z, 2012, PEDIATRICS, P129
Ciourchesne E, 2003, JAMA-J AM MED ASSOC, V290, P337
Courchesne E, 1992, NEW DIRECTIONS MENTA, P19
Courchesne E, 2011, JAMA-J AM MED ASSOC, V306, P2001, DOI 10.1001/jama.2011.1638
Dawson G, 2011, CURR OPIN PEDIATR, V23, P616, DOI 10.1097/MOP.0b013e32834cf082
FOSS JM, 1991, ANN DYSLEXIA, V41, P128, DOI 10.1007/BF02648082
Goldberg KB, 2001, INFORM PROCESSING PE
Handen BL, 2011, INT J ADOLESC MED HL, V233, P167
Handler SM, 2011, PEDIATRICS, V127, pE818, DOI 10.1542/peds.2010-3670
Hebert AR, 2008, AM ACAD CLIN NEUROPS, V7, P617
Hertle RW, 1995, OPHTHALMOLOGIST LEAR
Hoyt CS, 1999, AM ORTHOPT J, V49, P23
LOU HC, 1989, ARCH NEUROL-CHICAGO, V46, P48
LOVAAS OI, 1987, J CONSULT CLIN PSYCH, V55, P3, DOI 10.1037/0022-006X.55.1.3
Maski KP, 2011, CURR OPIN PEDIATR, V23, P609, DOI 10.1097/MOP.0b013e32834c9282
Matson ML, 2011, RES DEV DISABIL, V32, P2304, DOI 10.1016/j.ridd.2011.07.036
Mesibov GB, 1994, AUTISM CHILDREN ADUL, P85
Nadeau KG, 1999, UNDERSTANDING GIRLS
Neul JL, 2004, NEUROSCIENTISTS, V10, P11
Pennington B. F., 1991, DIAGNOSING LEARNING
PENNINGTON BF, 1982, CHILD DEV, V53, P1182, DOI 10.1111/j.1467-8624.1982.tb04155.x
Rourke B.P., 1995, SYNDROME NONVERBAL L
Shaywitz BA, 2002, BIOL PSYCHIAT, V52, P101, DOI 10.1016/S0006-3223(02)01365-3
SHAYWITZ BA, 1995, J CHILD NEUROL, V10, pS50
Shaywitz S, 2003, OVERCOMING DYSLEXIA, P266
Shaywitz SE, 1998, NEW ENGL J MED, V338, P307, DOI 10.1056/NEJM199801293380507
Silver WG, 2012, PEDIATR CLIN N AM, V59, P25
Suarez MA, 2012, PEDIATR CLIN N AM, V59, P203, DOI 10.1016/j.pcl.2011.10.012
Weissman L, 2010, AUTISM SPECTRUM DISO
Wolraich, 2005, PEDIATRICS, V115, P1734
NR 37
TC 0
Z9 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1040-8738
J9 CURR OPIN OPHTHALMOL
JI Curr. Opin. Ophthalmol.
PD SEP
PY 2012
VL 23
IS 5
BP 377
EP 383
DI 10.1097/ICU.0b013e32835720e2
PG 7
WC Ophthalmology
SC Ophthalmology
GA 993PT
UT WOS:000307872700006
PM 22847031
ER
PT J
AU Vedi, K
Bernard, S
AF Vedi, Kristan
Bernard, Sarah
TI The mental health needs of children and adolescents with learning
disabilities
SO CURRENT OPINION IN PSYCHIATRY
LA English
DT Review
DE CAMHS; children; learning disability; mental health; young people
ID AUTISM SPECTRUM DISORDERS; EYE-MOVEMENT SLEEP; INTELLECTUAL DISABILITY;
POPULATION PREVALENCE; CHALLENGING BEHAVIOR; EMOTIONAL-PROBLEMS;
PSYCHOPATHOLOGY; SERVICES; ADULTS; EPIDEMIOLOGY
AB Purpose of review
To provide an update on the mental health needs of children and adolescents with learning disabilities, by examining salient studies published predominantly in the last 12-18 months.
Recent findings
There have been further articles published supporting the findings of earlier landmark studies demonstrating an increased prevalence of mental health disorders in young people with learning disabilities. These articles suggest higher rates of comorbidity than were previously recognized. There are few published studies pertaining to the effectiveness of psychological and pharmacological treatments, although there is a recognition that the latter are more routinely and perhaps inappropriately administered. Antipsychotics are the most commonly prescribed group of medications and, despite a lack of evidence, continue to be prescribed more to address challenging behaviours rather than in the treatment of an identified psychiatric disorder. Reviews examining services and policies in other countries further highlight that the health and social care needs of individuals with learning disabilities are receiving more attention, with a shared vision that services should be inclusive and preferably community based.
Summary
Although there is improved knowledge of the rates of mental health disorders in young people with learning disabilities, in clinical practice these mental health needs continue to be underrecognized and untreated.
C1 [Bernard, Sarah] S London & Maudsley NHS Fdn Trust, Mental Hlth Child & Adolescent Learning Disabil S, London, England.
RP Bernard, S (reprint author), Maudsley Hosp & Inst Psychiat, Michael Rutter Ctr, Denmark Hill, London SE5 8AZ, England.
EM sarah.bernard@slam.nhs.uk
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
Anagnostopoulos DC, 2011, CURR OPIN PSYCHIATR, V24, P425, DOI 10.1097/YCO.0b013e3283486cd3
Bhaumik S, 2011, BRIT J PSYCHIAT, V198, P428, DOI 10.1192/bjp.bp.110.085084
Birch HG, 1971, ARCH DIS CHILD, V46, P742
Buckley AW, 2010, ARCH PEDIAT ADOL MED, V164, P1032, DOI 10.1001/archpediatrics.2010.202
Buckley AW, 2011, J CHILD ADOL PSYCHOP, V21, P353, DOI 10.1089/cap.2010.0121
Dekker MC, 2003, J AM ACAD CHILD PSY, V42, P915, DOI 10.1097/01.CHI.0000046892.27264.1A
Dekker MC, 2002, J CHILD PSYCHOL PSYC, V43, P1087, DOI 10.1111/1469-7610.00235
Einfeld S, 2009, RUTTERS CHILD ADOLES, P820
Einfeld SL, 1996, J INTELL DISABIL RES, V40, P99, DOI 10.1111/j.1365-2788.1996.tb00611.x
Einfeld SL, 2006, JAMA-J AM MED ASSOC, V296, P1981, DOI 10.1001/jama.296.16.1981
Einfeld SL, 1996, J INTELL DISABIL RES, V40, P91, DOI 10.1111/j.1365-2788.1996.tb00610.x
Einfeld SL, 2011, J INTELLECT DEV DIS, V36, P137, DOI 10.1080/13668250.2011.572548
Eldevik S, 2009, J CLIN CHILD ADOLESC, V38, P439, DOI 10.1080/15374410902851739
Emerson E, 2007, BRIT J PSYCHIAT, V191, P493, DOI 10.1192/bjp.bp.107.038729
Emerson E, 2006, J APPL RES INTELLECT, V19, P121, DOI 10.1111/j.1468-3148.2006.00305.x
Emerson E., 1992, MENT HANDICAP RES, V5, P49
Emerson E, 2010, SOC PSYCH PSYCH EPID, V45, P579, DOI 10.1007/s00127-009-0100-y
Frighi V, 2011, BRIT J PSYCHIAT, V199, P289, DOI 10.1192/bjp.bp.110.085670
Hassiotis A, 2012, J APPL RES INTELLECT, V25, P252, DOI 10.1111/j.1468-3148.2011.00662.x
Holmboe O, 2011, INT J MENT HEALTH SY, V5, DOI 10.1186/1752-4458-5-22
Howlin P, 2009, AJIDD-AM J INTELLECT, V114, P23, DOI 10.1352/2009.114:23;nd41
Ispanovic-Radojkovic V, 2011, CURR OPIN PSYCHIATR, V24, P419, DOI 10.1097/YCO.0b013e3283480173
Kleve Liv, 2011, Clin Child Psychol Psychiatry, V16, P253, DOI 10.1177/1359104510366280
Kwok HWM, 2011, CURR OPIN PSYCHIATR, V24, P408, DOI 10.1097/YCO.0b013e328348810c
Lin LP, 2011, CURR OPIN PSYCHIATR, V24, P413, DOI 10.1097/YCO.0b013e328346176e
Linna SL, 1999, EUR CHILD ADOLES PSY, V8, P77
Matson JL, 2009, RES DEV DISABIL, V30, P1107, DOI 10.1016/j.ridd.2009.06.003
McCarthy J, 2010, RES DEV DISABIL, V31, P362, DOI 10.1016/j.ridd.2009.10.009
Menon K, 2012, ADV MENTAL HLTH INTE, V6, P62
Molteno G, 2001, J INTELL DISABIL RES, V45, P515
Oeseburg B, 2011, INTELLECT DEV DISAB, V49, P59, DOI 10.1352/1934-9556-49.2.59
Romeo R, 2009, J INTELL DISABIL RES, V53, P633, DOI 10.1111/j.1365-2788.2009.01180.x
RUTTER M, 1976, PSYCHOL MED, V6, P313
Stromme P, 2000, DEV MED CHILD NEUROL, V42, P266, DOI 10.1017/S0012162200000451
Tonge BJ, 2003, INT REV RES MENT RET, V26, P61, DOI 10.1016/S0074-7750(03)01002-4
Totsika V, 2011, J CHILD PSYCHOL PSYC, V52, P91, DOI 10.1111/j.1469-7610.2010.02295.x
Weisleder P, 2011, J CHILD NEUROL, V26, P1052, DOI 10.1177/0883073811413279
NR 38
TC 1
Z9 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0951-7367
J9 CURR OPIN PSYCHIATR
JI Curr. Opin. Psychiatr.
PD SEP
PY 2012
VL 25
IS 5
BP 353
EP 358
DI 10.1097/YCO.0b013e3283566843
PG 6
WC Psychiatry
SC Psychiatry
GA 986XN
UT WOS:000307380800004
PM 22842658
ER
PT J
AU Guo, H
Xun, GL
Peng, Y
Xiang, XY
Xiong, ZM
Zhang, LS
He, YQ
Xu, XJ
Liu, YL
Lu, LN
Long, ZG
Pan, Q
Hu, ZM
Zhao, JP
Xia, K
AF Guo, Hui
Xun, Guanglei
Peng, Yu
Xiang, Xinying
Xiong, Zhimin
Zhang, Lusi
He, Yiqun
Xu, Xiaojuan
Liu, Yalan
Lu, Lina
Long, Zhigao
Pan, Qian
Hu, Zhengmao
Zhao, Jingping
Xia, Kun
TI Disruption of Contactin 4 in two subjects with autism in Chinese
population
SO GENE
LA English
DT Article
DE Autism; Contactin 4 (CNTN4); Copy number variation (CNV); Axon
connection
ID COPY NUMBER VARIATION; DISORDERS; TWIN
AB Autism is a heterogeneous childhood neurodevelopmental disorder that is characterised by deficits in verbal communication, impaired social interactions, restricted interests and repetitive behaviours. Using an Illumina HumanCNV370-Quad BeadChip, we identified two Han Chinese individuals with autism and large duplications (similar to 1.6 Mb and similar to 2.4 Mb) disrupting the same CNTN4 gene. CNTN4 encodes a protein that functions as a cell-adhesion molecule and may play an essential role in the formation of axon connections in the developing nervous system. The disruption of this gene has been reported to be the cause of the 3p deletion syndrome and also a possible susceptibility factor for autism spectrum disorders (ASDs). Our results suggest that rare copy number variations (CNVs) in CNTN4 may also influence autism susceptibility in Asian populations. Interestingly, a comparison of the clinical phenotypes between the two subjects revealed that the subject with the 2.4 Mb CNV (involving several other genes) presented with a more severe phenotype than the subject with the 1.6 Mb CNV (disrupting only CNTN4 and CNTN6). This suggests that other genes in the nearby region may contribute to the pathogenesis. (C) 2012 Elsevier B.V. All rights reserved.
C1 [Guo, Hui; Peng, Yu; Xiang, Xinying; Xiong, Zhimin; Zhang, Lusi; Xu, Xiaojuan; Liu, Yalan; Lu, Lina; Long, Zhigao; Pan, Qian; Hu, Zhengmao; Zhao, Jingping; Xia, Kun] Cent S Univ, State Key Lab Med Genet, Changsha, Hunan, Peoples R China.
[Guo, Hui; Xiang, Xinying; Xiong, Zhimin; Hu, Zhengmao; Xia, Kun] Cent S Univ, Sch Biol Sci & Technol, Changsha, Hunan, Peoples R China.
[Xun, Guanglei; He, Yiqun; Zhao, Jingping] Cent S Univ, Dept Mental Hlth Inst, Xiangya Hosp 2, Changsha, Hunan, Peoples R China.
[Xun, Guanglei] Shandong Mental Hlth Ctr, Jinan, Peoples R China.
[He, Yiqun] Xinxiang Med Univ, Affiliated Hosp 2, Xinxiang, Peoples R China.
RP Zhao, JP (reprint author), Cent S Univ, Mental Hlth Inst, Xiangya Hosp 2, 139 Renmin Middle Rd, Changsha, Hunan, Peoples R China.
EM zhaojingpinghunan@yahoo.com.cn; xiakun@sklmg.edu.cn
FU National Basic Research Program of China [2012CB517902, 2010CB529601];
Ministry of Education of China [2011ybjz010]
FX We thank the autism patients and their family members who participated
in this study. This work was supported by the National Basic Research
Program of China (2012CB517902 and 2010CB529601) and a Scholarship Award
for Excellent Doctoral Student Granted by the Ministry of Education of
China (2011ybjz010).
CR Abrahams BS, 2008, NAT REV GENET, V9, P341, DOI 10.1038/nrg2346
American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th
BAILEY A, 1995, PSYCHOL MED, V25, P63
Fernandez T, 2004, AM J HUM GENET, V74, P1286, DOI 10.1086/421474
Fombonne E, 2005, J CLIN PSYCHIAT, V66, P3
Glessner JT, 2009, NATURE, V459, P569, DOI 10.1038/nature07953
Hansford LM, 2003, CYTOGENET GENOME RES, V101, P17, DOI 10.1159/000073412
Higgins JJ, 2008, NEUROGENETICS, V9, P219, DOI 10.1007/s10048-008-0128-2
JORDE LB, 1991, AM J HUM GENET, V49, P932
LICHTER P, 1990, SCIENCE, V247, P64, DOI 10.1126/science.2294592
Pinto D, 2010, NATURE, V466, P368, DOI 10.1038/nature09146
Roohi J, 2009, J MED GENET, V46, P176, DOI 10.1136/jmg.2008.057505
Sebat J, 2007, SCIENCE, V316, P445, DOI 10.1126/science.1138659
Sousa I, 2010, MOL AUTISM, V1, DOI 10.1186/2040-2392-1-7
STEFFENBURG S, 1989, J CHILD PSYCHOL PSYC, V30, P405, DOI 10.1111/j.1469-7610.1989.tb00254.x
Wang K, 2007, GENOME RES, V17, P1665, DOI 10.1101/gr.6861907
Weiss LA, 2008, NEW ENGL J MED, V358, P667, DOI 10.1056/NEJMoa075974
NR 17
TC 3
Z9 4
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-1119
J9 GENE
JI Gene
PD SEP 1
PY 2012
VL 505
IS 2
BP 201
EP 205
DI 10.1016/j.gene.2012.06.051
PG 5
WC Genetics & Heredity
SC Genetics & Heredity
GA 991IE
UT WOS:000307693900001
PM 22750301
ER
PT J
AU Alesi, V
Bertoli, M
Barrano, G
Torres, B
Pusceddu, S
Pastorino, M
Perria, C
Nardone, AM
Novelli, A
Serra, G
AF Alesi, Viola
Bertoli, Marta
Barrano, Giuseppe
Torres, Barbara
Pusceddu, Silvia
Pastorino, Myriam
Perria, Chiara
Nardone, Anna Maria
Novelli, Antonio
Serra, Gigliola
TI 335.4 kb microduplication in chromosome band Xp11.2p11.3 associated with
developmental delay, growth retardation, autistic disorder and
dysmorphic features
SO GENE
LA English
DT Article
DE X-linked mental retardation; ZNF81 duplication; Intellectual disability;
Autism spectrum disorder
ID LINKED MENTAL-RETARDATION; MUTATIONS; GENE
AB About 10% of causative mutations for mental retardation in male patients involve X chromosome (X-linked mental retardation, XLMR).
We describe a case of a 3-year-old boy presenting with developmental delay, autistic features and growth and speech delay. Array-CGH analysis detected a microduplication on the X chromosome (Xp11.2p11.3), spanning 335.4 kb and including 3 known genes (ZNF81, ZNF182 and SPACA5).
Genome-wide association studies show that approximately 30% of mutations causing XLMR are located in Xp11.2p11.3, where few pathogenic genes have been identified to date (such as ZNF41, PQB1 and ZNF81). ZNF81 codifies a zinc finger protein and mutations (non-sense mutations, deletions and structural rearrangements) involving this gene have already been described in association with mental retardation. Larger duplications in the same region have also been observed in association with mental retardation, and, in one case, the over-expression of ZNF81 has also been verified by mRNA quantification. No duplications of the single gene have been identified.
To our knowledge, the microduplication found in our patient is the smallest ever described in Xp11.2p11.3. This suggests that the over-expression of ZNF81 could have pathological effects. (C) 2012 Elsevier B.V. All rights reserved.
C1 [Torres, Barbara; Novelli, Antonio] CSS Mendel Inst, I-00198 Rome, Italy.
[Alesi, Viola; Bertoli, Marta; Barrano, Giuseppe] S Pietro Fatebenefratelli Hosp, UOSD Med Genet, Rome, Italy.
[Pusceddu, Silvia; Pastorino, Myriam; Perria, Chiara; Serra, Gigliola] Univ AOU Sassari, Ist NeuroPsichiatria Infantile, Sassari, Italy.
[Nardone, Anna Maria] Fdn Policlin Tor Vergata, UOC, Med Genet Lab, Rome, Italy.
RP Novelli, A (reprint author), CSS Mendel Inst, Viale Regina Margherita 261, I-00198 Rome, Italy.
EM a.novelli@css-mendel.it
CR Chelly J, 2001, NAT REV GENET, V2, P669, DOI 10.1038/35088558
Chiurazzi P, 2008, EUR J HUM GENET, V16, P422, DOI 10.1038/sj.ejhg.5201994
Chung BHY, 2011, EUR J MED GENET, V54, pE516, DOI 10.1016/j.ejmg.2011.05.008
El-Hattab AW, 2011, CLIN GENET, V79, P531, DOI 10.1111/j.1399-0004.2010.01496.x
Freude K, 2004, AM J HUM GENET, V75, P305, DOI 10.1086/422507
Frietze S, 2010, J BIOL CHEM, V285, P1393, DOI 10.1074/jbc.M109.063032
Giorda R, 2009, AM J HUM GENET, V85, P394, DOI 10.1016/j.ajhg.2009.08.001
Hamel BCJ, 1999, J MED GENET, V36, P140
Jensen LR, 2005, AM J HUM GENET, V76, P227, DOI 10.1086/427563
Kalscheuer VM, 2003, NAT GENET, V35, P313, DOI 10.1038/ng1264
Kleefstra T, 2004, J MED GENET, V41, P394, DOI 10.1136/jmg.2003.016972
Leonard H, 2002, MENT RETARD DEV D R, V8, P117, DOI 10.1002/mrdd.10031
Minks J, 2008, J CLIN INVEST, V118, P20, DOI 10.1172/JCI34470
Qiao Y, 2008, CLIN GENET, V74, P134, DOI 10.1111/j.1399-0004.2008.01028.x
Ropers HH, 2003, TRENDS GENET, V19, P316, DOI 10.1016/S0168-9525(03)00113-6
Ropers HH, 2005, NAT REV GENET, V6, P46, DOI 10.1038/nrg1501
Shoichet SA, 2003, AM J HUM GENET, V73, P1341, DOI 10.1086/380309
Stevenson RE, 2002, CYTOGENET GENOME RES, V99, P265, DOI 10.1159/000071603
Tupler R, 2001, NATURE, V409, P832, DOI 10.1038/35057011
van Karnebeek CDM, 2005, AM J MENT RETARD, V110, P253, DOI 10.1352/0895-8017(2005)110[253:EOMRIC]2.0.CO;2
NR 20
TC 4
Z9 5
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-1119
J9 GENE
JI Gene
PD SEP 1
PY 2012
VL 505
IS 2
BP 384
EP 387
DI 10.1016/j.gene.2012.05.031
PG 4
WC Genetics & Heredity
SC Genetics & Heredity
GA 991IE
UT WOS:000307693900028
PM 22634100
ER
PT J
AU Cross, ES
Liepelt, R
Hamilton, AFD
Parkinson, J
Ramsey, R
Stadler, W
Prinz, W
AF Cross, Emily S.
Liepelt, Roman
Hamilton, Antonia F. de C.
Parkinson, Jim
Ramsey, Richard
Stadler, Waltraud
Prinz, Wolfgang
TI Robotic movement preferentially engages the action observation network
SO HUMAN BRAIN MAPPING
LA English
DT Article
DE action observation network; functional MRI; parietal; premotor; robots;
dance
ID MIRROR-NEURON SYSTEM; AUTISM SPECTRUM DISORDERS; INFERIOR FRONTAL GYRUS;
SOCIAL COGNITION; MOTOR; FMRI; MOTION; INTERFERENCE; PERCEPTION;
SIMULATION
AB As humans, we gather a wide range of information about other people from watching them move. A network of parietal, premotor, and occipitotemporal regions within the human brain, termed the action observation network (AON), has been implicated in understanding others' actions by means of an automatic matching process that links observed and performed actions. Current views of the AON assume a matching process biased towards familiar actions; specifically, those performed by conspecifics and present in the observer's motor repertoire. In this study, we test how this network responds to form and motion cues when observing natural human motion compared to rigid robotic-like motion across two independent functional neuroimaging experiments. In Experiment 1, we report the surprising finding that premotor, parietal, occipitotemporal regions respond more robustly to rigid, robot-like motion than natural human motion. In Experiment 2, we replicate and extend this finding by demonstrating that the same pattern of results emerges whether the agent is a human or a robot, which suggests the preferential response to robot-like motion is independent of the agent's form. These data challenge previous ideas about AON function by demonstrating that the core nodes of this network can be flexibly engaged by novel, unfamiliar actions performed by both human and non-human agents. As such, these findings suggest that the AON is sensitive to a broader range of action features beyond those that are simply familiar. Hum Brain Mapp 33:22382254, 2012. (c) 2011 Wiley Periodicals, Inc.
C1 [Cross, Emily S.] Radboud Univ Nijmegen, Dept Social & Cultural Psychol, Inst Behav Sci, Donders Inst Brain Cognit & Behav, NL-6500 HE Nijmegen, Netherlands.
[Cross, Emily S.; Liepelt, Roman; Parkinson, Jim; Stadler, Waltraud; Prinz, Wolfgang] Max Planck Inst Human Cognit & Brain Sci, Dept Psychol, Leipzig, Germany.
[Liepelt, Roman] Univ Munster, Dept Psychol, Munster, Germany.
[Hamilton, Antonia F. de C.; Ramsey, Richard] Univ Nottingham, Sch Psychol, Nottingham NG7 2RD, England.
RP Cross, ES (reprint author), Radboud Univ Nijmegen, Dept Social & Cultural Psychol, Inst Behav Sci, Donders Inst Brain Cognit & Behav, POB 9014, NL-6500 HE Nijmegen, Netherlands.
EM e.cross@psych.ru.nl
RI Cross, Emily/B-4565-2009; Hamilton, Antonia/B-3612-2008
OI Cross, Emily/0000-0002-1671-5698; Hamilton, Antonia/0000-0001-8000-0219
FU Alexander von Humboldt Foundation
FX Contract grant sponsor: Alexander von Humboldt Foundation.
CR Adolphs R, 2010, NEURON, V65, P752, DOI 10.1016/j.neuron.2010.03.006
Aglioti SM, 2008, NAT NEUROSCI, V11, P1109, DOI 10.1038/nn.2182
Alaerts K, 2010, NEUROPSYCHOLOGIA, V48, P2082, DOI 10.1016/j.neuropsychologia.2010.03.029
Avenanti A, 2010, CURR BIOL, V20, P1018, DOI 10.1016/j.cub.2010.03.071
Beer AL, 2009, EUR J NEUROSCI, V30, P703, DOI 10.1111/j.1460-9568.2009.06857.x
Bobick AF, 1997, PHILOS T ROY SOC B, V352, P1257, DOI 10.1098/rstb.1997.0108
Brass M, 2001, ACTA PSYCHOL, V106, P3, DOI 10.1016/S0001-6918(00)00024-X
Brass M, 2007, CURR BIOL, V17, P2117, DOI 10.1016/j.cub.2007.11.057
Buccino G, 2004, J COGNITIVE NEUROSCI, V16, P114, DOI 10.1162/089892904322755601
Calvo-Merino B, 2005, CEREB CORTEX, V15, P1243, DOI 10.1093/cercor/bhi007
Chaminade T, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0011577
Chaminade T, 2005, INT C DEVEL LEARN, P96
Chong TTJ, 2008, NEUROIMAGE, V40, P298, DOI 10.1016/j.neuroimage.2007.11.030
Costantini M, 2005, CEREB CORTEX, V15, P1761, DOI 10.1093/cercor/bhi053
Cross ES, 2009, EUR J NEUROSCI, V30, P1383, DOI 10.1111/j.1460-9568.2009.06941.x
Cross ES, 2006, NEUROIMAGE, V31, P1257, DOI 10.1016/j.neuroimage.2006.01.033
Cross ES, 2009, CEREB CORTEX, V19, P315, DOI 10.1093/cercor/bhn083
Dapretto M, 2006, NAT NEUROSCI, V9, P28, DOI 10.1038/nn1611
Decety J, 2003, TRENDS COGN SCI, V7, P527, DOI 10.1016/j.tics.2003.10.004
De Lange FP, 2008, CURR BIOL, V18, P454, DOI 10.1016/j.cub.2008.02.057
Engel A, 2008, SOC NEUROSCI, V3, P368, DOI 10.1080/17470910701612793
Felician O, 2009, NEUROPSYCHOLOGIA, V47, P1909, DOI 10.1016/j.neuropsychologia.2009.03.001
Gallese V, 1998, TRENDS COGN SCI, V2, P493, DOI 10.1016/S1364-6613(98)01262-5
Gallese V, 2004, TRENDS COGN SCI, V8, P396, DOI 10.1016/j.tics.2004.07.002
Gallese Vittorio, 2007, Novartis Found Symp, V278, P3
Gallese V., 2007, NOVART FDN SYMP, V278, P89
Gallese V., 2007, NOVART FDN SYMP, V278, P216
Gallese V., 2007, NOVART FDN SYMP, V278, P12
Gazzola V, 2009, CEREB CORTEX, V19, P1239, DOI 10.1093/cercor/bhn181
Gazzola V, 2007, NEUROIMAGE, V35, P1674, DOI 10.1016/j.neuroimage.2007.02.003
Gowen E, 2008, NEUROPSYCHOLOGIA, V46, P1060, DOI 10.1016/j.neuropsychologia.2007.11.004
Grezes J, 2001, HUM BRAIN MAPP, V12, P1, DOI 10.1002/1097-0193(200101)12:1<1::AID-HBM10>3.0.CO;2-V
Hamilton AFD, 2006, J NEUROSCI, V26, P1133, DOI 10.1523/JNEUROSCI.4551-05.2006
Jackson PL, 2006, NEUROIMAGE, V31, P429, DOI 10.1016/j.neuroimage.2005.11.026
James W, 1890, PRINCIPLES PSYCHOL
Jastorff J, 2011, CEREB CORTEX, V21, P318, DOI 10.1093/cercor/bhq098
Kessler K, 2006, NEUROIMAGE, V33, P227, DOI 10.1016/j.neuroimage.2006.06.014
Kilner James M, 2007, Cogn Process, V8, P159, DOI 10.1007/s10339-007-0170-2
Kilner J, 2007, SOC NEUROSCI-UK, V2, P158, DOI 10.1080/17470910701428190
Kilner JM, 2003, CURR BIOL, V13, P522, DOI 10.1016/S0960-9822(03)00165-9
Kilner JM, 2007, NEUROREPORT, V18, P619, DOI 10.1097/WNR.0b013e3281139ed0
Kilner JM, 2009, J NEUROSCI, V29, P10153, DOI 10.1523/JNEUROSCI.2668-09.2009
Liepelt R, 2010, COGNITION, V115, P426, DOI 10.1016/j.cognition.2010.03.003
Liepelt R, 2008, NEUROIMAGE, V43, P784, DOI 10.1016/j.neuroimage.2008.08.007
Liepelt R, 2009, NEUROPSYCHOLOGIA, V47, P268, DOI 10.1016/j.neuropsychologia.2008.07.008
Liepelt R, 2010, EXP PSYCHOL, V57, P221, DOI 10.1027/1618-3169/a000028
Liew SL, 2011, HUM BRAIN MAPP, V32, P1986, DOI 10.1002/hbm.21164
Marsh LE, 2011, NEUROIMAGE, V56, P1511, DOI 10.1016/j.neuroimage.2011.02.003
Meltzoff AN, 2007, DEVELOPMENTAL SCI, V10, P126, DOI 10.1111/j.1467-7687.2007.00574.x
Miura N, 2010, SOC NEUROSCI-UK, V5, P40, DOI 10.1080/17470910903083256
Neal A, 2010, EUR J NEUROSCI, V32, P1765, DOI 10.1111/j.1460-9568.2010.07435.x
Oberman LM, 2005, COGNITIVE BRAIN RES, V24, P190, DOI 10.1016/j.cogbrainres.2005.01.014
Obhi SS, 2010, EXP BRAIN RES, V203, P427, DOI 10.1007/s00221-010-2253-z
OLDFIELD RC, 1971, NEUROPSYCHOLOGIA, V9, P97, DOI 10.1016/0028-3932(71)90067-4
Oosterhof NN, 2010, J NEUROPHYSIOL, V104, P1077, DOI 10.1152/jn.00326.2010
Peelen MV, 2007, NAT REV NEUROSCI, V8, P636, DOI 10.1038/nrn2195
Press C, 2011, NEUROSCI BIOBEHAV R, V35, P1410, DOI 10.1016/j.neubiorev.2011.03.004
Prinz W., 1990, RELATIONSHIPS PERCEP, P167, DOI DOI 10.1007/978-3-642-75348-0_7
Ramsey R, 2010, NEUROPSYCHOLOGIA, V48, P2773, DOI 10.1016/j.neuropsychologia.2010.04.028
Rizzolatti G, 2004, ANNU REV NEUROSCI, V27, P169, DOI 10.1146/annurev.neuro.27.070203.144230
Schippers MB, 2010, P NATL ACAD SCI USA, V107, P9388, DOI 10.1073/pnas.1001791107
Schubotz RI, 2007, TRENDS COGN SCI, V11, P211, DOI 10.1016/j.tics.2007.02.006
Shimada S, 2010, BRAIN COGNITION, V72, P394, DOI 10.1016/j.bandc.2009.11.005
Spunt RP, 2011, J COGNITIVE NEUROSCI, V23, P63, DOI 10.1162/jocn.2010.21446
Stanley J, 2010, NEUROIMAGE, V52, P389, DOI 10.1016/j.neuroimage.2010.04.025
Tai YF, 2004, CURR BIOL, V14, P117, DOI 10.1016/j.cub.2004.01.005
VanOostende S, 1997, CEREB CORTEX, V7, P690, DOI 10.1093/cercor/7.7.690
Wheatley T, 2007, PSYCHOL SCI, V18, P469, DOI 10.1111/j.1467-9280.2007.01923.x
Zacks JM, 2002, NEUROIMAGE, V16, P857, DOI 10.1006/nimg.2002.1129
Zentgraf K, 2005, NEUROIMAGE, V26, P662, DOI 10.1016/j.neuroimage.2005.02.015
NR 70
TC 28
Z9 28
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1065-9471
J9 HUM BRAIN MAPP
JI Hum. Brain Mapp.
PD SEP
PY 2012
VL 33
IS 9
BP 2238
EP 2254
DI 10.1002/hbm.21361
PG 17
WC Neurosciences; Neuroimaging; Radiology, Nuclear Medicine & Medical
Imaging
SC Neurosciences & Neurology; Radiology, Nuclear Medicine & Medical Imaging
GA 989XB
UT WOS:000307593400018
PM 21898675
ER
PT J
AU Liu, J
Koscielska, KA
Cao, ZY
Hulsizer, S
Grace, N
Mitchell, G
Nacey, C
Githinji, J
McGee, J
Garcia-Arocena, D
Hagerman, RJ
Nolta, J
Pessah, IN
Hagerman, PJ
AF Liu, Jing
Koscielska, Katarzyna A.
Cao, Zhengyu
Hulsizer, Susan
Grace, Natalie
Mitchell, Gaela
Nacey, Catherine
Githinji, Jackline
McGee, Jeannine
Garcia-Arocena, Dolores
Hagerman, Randi J.
Nolta, Jan
Pessah, Isaac N.
Hagerman, Paul J.
TI Signaling defects in iPSC-derived fragile X premutation neurons
SO HUMAN MOLECULAR GENETICS
LA English
DT Article
ID PLURIPOTENT STEM-CELLS; TREMOR/ATAXIA SYNDROME; RETT-SYNDROME; CALCIUM
OSCILLATIONS; REPEAT EXPANSION; MOUSE MODEL; FMR1; CHROMOSOME;
INACTIVATION; FIBROBLASTS
AB Fragile X-associated tremor/ataxia syndrome (FXTAS) is a leading monogenic neurodegenerative disorder affecting premutation carriers of the fragile X (FMR1) gene. To investigate the underlying cellular neuropathology, we produced induced pluripotent stem cell-derived neurons from isogenic subclones of primary fibroblasts of a female premutation carrier, with each subclone bearing exclusively either the normal or the expanded (premutation) form of the FMR1 gene as the active allele. We show that neurons harboring the stably-active, expanded allele (EX-Xa) have reduced postsynaptic density protein 95 protein expression, reduced synaptic puncta density and reduced neurite length. Importantly, such neurons are also functionally abnormal, with calcium transients of higher amplitude and increased frequency than for neurons harboring the normal-active allele. Moreover, a sustained calcium elevation was found in the EX-Xa neurons after glutamate application. By excluding the individual genetic background variation, we have demonstrated neuronal phenotypes directly linked to the FMR1 premutation. Our approach represents a unique isogenic, X-chromosomal epigenetic model to aid the development of targeted therapeutics for FXTAS, and more broadly as a model for the study of common neurodevelopmental (e.g. autism) and neurodegenerative (e.g. Parkinsonism, dementias) disorders.
C1 [Koscielska, Katarzyna A.; Hulsizer, Susan; Garcia-Arocena, Dolores; Hagerman, Paul J.] Univ Calif Davis, Sch Med, Dept Biochem & Mol Med, Davis, CA 95616 USA.
[Liu, Jing; Grace, Natalie; Mitchell, Gaela; Nacey, Catherine; Githinji, Jackline; McGee, Jeannine; Nolta, Jan] Univ Calif Davis, Stem Cell Program, Sacramento, CA 95817 USA.
[Liu, Jing; Grace, Natalie; Mitchell, Gaela; Nacey, Catherine; Githinji, Jackline; McGee, Jeannine; Nolta, Jan] Univ Calif Davis, Inst Regenerat Cures, Sacramento, CA 95817 USA.
[Hagerman, Randi J.] Univ Calif Davis, Sch Med, Dept Pediat, Sacramento, CA 95817 USA.
[Hagerman, Randi J.; Pessah, Isaac N.; Hagerman, Paul J.] Univ Calif Davis, MIND Inst, Sacramento, CA 95817 USA.
[Cao, Zhengyu; Hulsizer, Susan; Pessah, Isaac N.] Univ Calif Davis, Sch Vet Med, Dept Mol Biosci, Davis, CA 95616 USA.
RP Hagerman, PJ (reprint author), Univ Calif Davis, Sch Med, Dept Biochem & Mol Med, 1 Shields Ave, Davis, CA 95616 USA.
EM pjhagerman@ucdavis.edu
RI cao, zhengyu/G-2527-2012
FU National Institutes of Health Challenge (ARRA) [RC1 AG036022]; National
Institutes of Health Interdisciplinary Research Consortium (IRC) [UL1
DE019583, RL1 AG032119, RL1 AG032115]; Shriners Hospital; NIH [R01
GM099688]; J.B. Johnson Foundation
FX This project is funded by a National Institutes of Health Challenge
(ARRA) grant [RC1 AG036022 to P.J.H.] and by a National Institutes of
Health Interdisciplinary Research Consortium (IRC) grant [UL1 DE019583
to P.J.H., RL1 AG032119 to P.J.H. and I.N.P., RL1 AG032115 to R.J.H].
J.L. is supported by the Shriners Hospital Fellowship and is the 2011
Wing Kai Fat Memorial Fund scholar; N.G. is a scholar of the California
Institute for Regenerative Medicine (CIRM) Bridges Program at CSUS and
UC Davis [CIRM TB1-01184]; J.N. is the recipient of an NIH Director's
Transformative Grant [R01 GM099688]. This research is also supported by
an unrestricted research grant from J.B. Johnson Foundation (I.N.P.),
and by facilities from the UC Davis MIND Institute.
CR Berman RF, 2009, J INVEST MED, V57, P837, DOI 10.231/JIM.0b013e3181af59d6
Berry-Kravis E, 2007, MOVEMENT DISORD, V22, P2018, DOI 10.1002/mds.21493
Brennand KJ, 2011, NATURE, V473, P221, DOI 10.1038/nature09915
Brouwer JR, 2008, J NEUROCHEM, V107, P1671, DOI 10.1111/j.1471-4159.2008.05747.x
Bruck T, 2011, STEM CELL RES, V6, P187, DOI 10.1016/j.scr.2010.12.001
Cao Z., 2012, HUM MOL GENET
Chambers SM, 2009, NAT BIOTECHNOL, V27, P275, DOI 10.1038/nbt.1529
Chen YC, 2010, HUM MOL GENET, V19, P196, DOI 10.1093/hmg/ddp479
Cheung AYL, 2011, HUM MOL GENET, V20, P2103, DOI 10.1093/hmg/ddr093
Cunningham CL, 2011, HUM MOL GENET, V20, P64, DOI 10.1093/hmg/ddq432
Dravid SM, 2004, BRAIN RES, V1006, P8, DOI 10.1016/j.brainres.2004.01.059
Entezam A, 2007, GENE, V395, P125, DOI 10.1016/j.gene.2007.02.026
FENG Y, 1995, SCIENCE, V268, P731, DOI 10.1126/science.7732383
Filipovic-Sadic S, 2010, CLIN CHEM, V56, P399, DOI 10.1373/clinchem.2009.136101
Garcia-Arocena D, 2010, HUM MOL GENET, V19, pR83, DOI 10.1093/hmg/ddq166
Hagerman PJ, 2008, J MED GENET, V45, P498, DOI 10.1136/jmg.2008.059055
Hagerman RJ, 2001, NEUROLOGY, V57, P127
Jacquemont S, 2004, JAMA-J AM MED ASSOC, V291, P460, DOI 10.1001/jama.291.4.460
Kim KY, 2011, P NATL ACAD SCI USA, V108, P14169, DOI 10.1073/pnas.1018979108
Lengner CJ, 2010, CELL, V141, P872, DOI 10.1016/j.cell.2010.04.010
Levenga J, 2010, TRENDS MOL MED, V16, P516, DOI 10.1016/j.molmed.2010.08.005
Lohmann C, 2005, CELL CALCIUM, V37, P403, DOI 10.1016/j.ceca.2005.01.008
LYON MF, 1961, NATURE, V190, P372, DOI 10.1038/190372a0
Maherali N, 2007, CELL STEM CELL, V1, P55, DOI 10.1016/j.stem.2007.05.014
Marchetto MCN, 2010, CELL, V143, P527, DOI 10.1016/j.cell.2010.10.016
Nichols J, 2009, CELL STEM CELL, V4, P487, DOI 10.1016/j.stem.2009.05.015
Nunez L, 1996, EUR J NEUROSCI, V8, P192, DOI 10.1111/j.1460-9568.1996.tb01180.x
Pomp O, 2011, CELL STEM CELL, V9, P156, DOI 10.1016/j.stem.2011.06.004
Rodriguez-Revenga L, 2009, EUR J HUM GENET, V17, P1359, DOI 10.1038/ejhg.2009.51
Segal I, 2000, Trends Neurosci, V23, P53
Sheridan SD, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0026203
Song F J, 2003, Health Technol Assess, V7, P1
Takahashi K, 2007, CELL, V131, P861, DOI 10.1016/j.cell.2007.11.019
Tassone F, 2004, J MED GENET, V41, DOI 10.1136/jmg.2003.012518
Tchieu J, 2010, CELL STEM CELL, V7, P329, DOI 10.1016/j.stem.2010.06.024
Urbach A, 2010, CELL STEM CELL, V6, P407, DOI 10.1016/j.stem.2010.04.005
Wang LW, 2010, NEUROTHERAPEUTICS, V7, P264, DOI 10.1016/j.nurt.2010.05.005
NR 37
TC 28
Z9 31
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0964-6906
J9 HUM MOL GENET
JI Hum. Mol. Genet.
PD SEP 1
PY 2012
VL 21
IS 17
BP 3795
EP 3805
DI 10.1093/hmg/dds207
PG 11
WC Biochemistry & Molecular Biology; Genetics & Heredity
SC Biochemistry & Molecular Biology; Genetics & Heredity
GA 988PX
UT WOS:000307504100006
PM 22641815
ER
PT J
AU Lakatosova, S
Ostatnikova, D
AF Lakatosova, Silvia
Ostatnikova, Daniela
TI Reelin and its complex involvement in brain development and function
SO INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
LA English
DT Article
DE Reelin; Development; Synaptic plasticity; Autism
ID CAJAL-RETZIUS CELLS; SYNAPTIC PLASTICITY; LIPOPROTEIN RECEPTORS;
EXPRESSION; GENE; SCHIZOPHRENIA; POLYMORPHISMS; TESTOSTERONE;
DISABLED-1; DISORDERS
AB Reelin is a neuroprotein with crucial role during neurodevelopment and also in postnatal period. It regulates neuronal migration and positioning in developing neocortex and cerebellar cortex. Postnatally it participates in regulation of dendritic and axonal growth, synaptogenesis, neurotransmission and it contribute to synaptic plasticity necessary for learning and memory functions. Role of Reelin seems to be rather complex, profound research gradually uncovers its further functions. Deficits of Reelin were detected in neuropsychiatric disorders such as schizophrenia, bipolar disorder and autism. Pathogenesis of these disorders is far from being clearly understood. Reelin contribution to these diseases seems to be vital, since genetic variants of Reelin were associated with these diseases and often influence symptom severity. Reelin is a promising candidate molecule with potential future use in diagnostics and therapy, however further detailed research is essential. (C) 2012 Elsevier Ltd. All rights reserved.
C1 [Lakatosova, Silvia; Ostatnikova, Daniela] Comenius Univ, Fac Med, Inst Physiol, Bratislava, Slovakia.
RP Lakatosova, S (reprint author), Sasinkova 2, Bratislava 81372, Slovakia.
EM silvia.lakatosova@gmail.com
CR Absil P, 2003, CELL TISSUE RES, V312, P81, DOI 10.1007/s00441-003-0701-9
Baron-Cohen S, 2005, SCIENCE, V310, P819, DOI 10.1126/science.1115455
Bock HH, 2004, J BIOL CHEM, V279, P33471, DOI 10.1074/jbc.M401770200
Chen Y, 2005, J NEUROSCI, V25, P8209, DOI 10.1523/JNEUROSCI.1951-05.2005
D'Arcangelo G, 1999, NEURON, V24, P471, DOI 10.1016/S0896-6273(00)80860-0
DARCANGELO G, 1995, NATURE, V374, P719, DOI 10.1038/374719a0
DeSilva U, 1997, GENOME RES, V7, P157, DOI 10.1101/gr.7.2.157
FALCONER DS, 1951, J GENET, V50, P192, DOI 10.1007/BF02996215
Fatemi SH, 2005, MOL PSYCHIATR, V10, P251, DOI 10.1038/sj.mp.4001613
Fatemi SH, 2001, NEUROREPORT, V12, P3209, DOI 10.1097/00001756-200110290-00014
Frotscher M, 1998, CURR OPIN NEUROBIOL, V8, P570, DOI 10.1016/S0959-4388(98)80082-2
Frotscher M, 1997, CELL TISSUE RES, V290, P315, DOI 10.1007/s004410050936
Geier DA, 2007, NEUROENDOCRINOL LETT, V28, P565
Goes FS, 2010, AM J MED GENET B, V153B, P549, DOI 10.1002/ajmg.b.31018
Grayson DR, 2005, P NATL ACAD SCI USA, V102, P9341, DOI 10.1073/pnas.0503736102
HadjSahraoui N, 1996, J NEUROGENET, V11, P45, DOI 10.3109/01677069609107062
Hellwig S, 2011, J NEUROSCI, V31, P2352, DOI 10.1523/JNEUROSCI.3984-10.2011
Herz J, 2006, NAT REV NEUROSCI, V7, P850, DOI 10.1038/nrn2009
Hiesberger T, 1999, NEURON, V24, P481, DOI 10.1016/S0896-6273(00)80861-2
Hong SE, 2000, NAT GENET, V26, P93
Jossin Y, 2004, J NEUROSCI, V24, P514, DOI 10.1523/JNEUROSCI.3408-03.2004
Kelemenova S, 2010, PSYCHIAT GENET, V20, P137, DOI 10.1097/YPG.0b013e32833a1eb3
Lakatosova S, 2010, ANS REDIVIVA, V52, P245
Maloku E, 2010, P NATL ACAD SCI USA, V107, P4407, DOI 10.1073/pnas.0914483107
Marin-Padilla M, 1998, TRENDS NEUROSCI, V21, P64, DOI 10.1016/S0166-2236(97)01164-8
Morimura T, 2005, J BIOL CHEM, V280, P16901, DOI 10.1074/jbc.M409048200
Persico AM, 2006, J NEURAL TRANSM, V113, P1373, DOI 10.1007/s00702-006-0441-6
Persico AM, 2001, MOL PSYCHIATR, V6, P150, DOI 10.1038/sj.mp.4000850
Pickett J, 2005, J NEUROPATH EXP NEUR, V64, P925, DOI 10.1097/01.jnen.0000186921.42592.6c
Quattrocchi CC, 2003, SCIENCE, V301, P649, DOI 10.1126/science.1082690
Rogers JT, 2011, LEARN MEMORY, V18, P558, DOI 10.1101/lm.2153511
Schmidtova E, 2010, ENDOCRINOLOGIST, V20, P245, DOI 10.1097/TEN.0b013e3181f661d2
Siebert JR, 2011, ANAT REC, V294, P759, DOI 10.1002/ar.21370
Soriano E, 2005, NEURON, V46, P389, DOI 10.1016/j.neuron.2005.04.019
Suzuki K, 2008, SCHIZOPHR RES, V98, P148, DOI 10.1016/j.schres.2007.09.029
Teixeira CM, 2011, NEUROPSYCHOPHARMACOL, P3
Wedenoja J, 2010, BIOL PSYCHIAT, V67, P983, DOI 10.1016/j.biopsych.2009.09.026
Weeber EJ, 2002, J BIOL CHEM, V277, P39944, DOI 10.1074/jbc.M205147200
NR 38
TC 10
Z9 10
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 1357-2725
J9 INT J BIOCHEM CELL B
JI Int. J. Biochem. Cell Biol.
PD SEP
PY 2012
VL 44
IS 9
BP 1501
EP 1504
DI 10.1016/j.biocel.2012.06.002
PG 4
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA 983BY
UT WOS:000307092400015
PM 22705982
ER
PT J
AU Dichter, GS
Sikich, L
Song, A
Voyvodic, J
Bodfish, JW
AF Dichter, Gabriel S.
Sikich, Linmarie
Song, Allen
Voyvodic, James
Bodfish, James W.
TI Functional Neuroimaging of Treatment Effects in Psychiatry:
Methodological Challenges and Recommendations
SO INTERNATIONAL JOURNAL OF NEUROSCIENCE
LA English
DT Article
DE clinical trials; fMRI; functional magnetic resonance imaging;
neurodevelopmental disorders; psychiatry
ID NORMAL BRAIN-DEVELOPMENT; TEST-RETEST RELIABILITY;
ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; COMMON STEREOTACTIC SPACE;
WORKING-MEMORY; CLINICAL-TRIALS; BLOOD-FLOW; NIH MRI; COGNITIVE
NEUROSCIENCE; PLACEBO TREATMENTS
AB Functional magnetic resonance imaging (fMRI) has helped to elucidate the neurobiological bases of psychiatric and neurodevelopmental disorders by localizing etiologically-relevant aberrations in brain function. Functional MRI also has shown great promise to help understand potential mechanisms of action of effective treatments for a range of psychiatric and neurodevelopmental disorders, including mood and anxiety disorders, schizophrenia, and autism. However, the use of fMRI to probe intervention effects in psychiatry is associated with unique methodological considerations, including the psychometric properties of repeated fMRI scans, how to assess potential relations between the effects of an intervention on symptoms and on specific brain activation patterns, and how to best make causal inferences about intervention effects on brain function. Additionally, the study of treatment effects in neurodevelopmental disorders presents additional unique challenges related to brain maturation, analysis methods, and the potential for motion artifacts. We review these methodological considerations and provide recommendations for best practices for each of these topics.
C1 [Dichter, Gabriel S.; Sikich, Linmarie; Bodfish, James W.] Univ N Carolina, Chapel Hill Sch Med, Carolina Inst Dev Disabil, Chapel Hill, NC 27599 USA.
[Dichter, Gabriel S.; Sikich, Linmarie; Bodfish, James W.] Univ N Carolina, Dept Psychiat, Chapel Hill Sch Med, Chapel Hill, NC 27599 USA.
[Dichter, Gabriel S.; Song, Allen; Voyvodic, James] Duke Univ, Med Ctr, Duke UNC Brain Imaging & Anal Ctr, Durham, NC USA.
RP Dichter, GS (reprint author), Univ N Carolina, Dept Psychiat, Sch Med, CB 7255,101 Manning Dr, Chapel Hill, NC 27599 USA.
EM dichter@med.unc.edu
FU [K23 MH081285]
FX Preparation of this manuscript was supported by K23 MH081285 to G.
Dichter.
CR Almli CR, 2007, NEUROIMAGE, V35, P308, DOI 10.1016/j.neuroimage.2006.08.058
American Psychiatric Association, 2000, DIAGN STAT MAN MENT
Aron AR, 2006, NEUROIMAGE, V29, P1000, DOI 10.1016/j.neuroimage.2005.08.010
Aylward EH, 2003, NEUROLOGY, V61, P212
Barch DM, 2009, SCHIZOPHRENIA BULL, V35, P109, DOI 10.1093/schbul/sbn163
Barch DM, 2011, BIOL PSYCHIAT, V70, P13, DOI 10.1016/j.biopsych.2011.01.004
Bent S, 2010, NEUROTHERAPEUTICS, V7, P232, DOI 10.1016/j.nurt.2010.05.011
Bookheimer SY, 2000, MENT RETARD DEV D R, V6, P161, DOI 10.1002/1098-2779(2000)6:3<161::AID-MRDD2>3.0.CO;2-W
Braunholtz DA, 2001, J CLIN EPIDEMIOL, V54, P217, DOI 10.1016/S0895-4356(00)00305-X
Brody AL, 2001, ARCH GEN PSYCHIAT, V58, P631, DOI 10.1001/archpsyc.58.7.631
Brown GG, 2007, NEUROPSYCHOL REV, V17, P107, DOI 10.1007/s11065-007-9028-8
Brown GG, 2003, J CEREBR BLOOD F MET, V23, P829, DOI 10.1097/01.WCB.0000071887.63724.B2
Burgund ED, 2002, NEUROIMAGE, V17, P184, DOI 10.1006/nimg.2002.1174
Buxton RB, 1998, MAGNET RESON MED, V39, P855, DOI 10.1002/mrm.1910390602
Caceres A, 2009, NEUROIMAGE, V45, P758, DOI 10.1016/j.neuroimage.2008.12.035
Carter CS, 2008, BIOL PSYCHIAT, V64, P4, DOI 10.1016/j.biopsych.2008.03.020
CASEY BJ, 1995, NEUROIMAGE, V2, P221, DOI 10.1006/nimg.1995.1029
Casey BJ, 2000, P NATL ACAD SCI USA, V97, P8728, DOI 10.1073/pnas.97.15.8728
Castellanos FX, 1996, NEUROLOGY, V47, P1581
Church JA, 2010, HUM BRAIN MAPP, V31, P852, DOI 10.1002/hbm.21036
Cohen JD, 2011, INT J DEV NEUROSCI
Dehaene-Lambertz G, 2002, SCIENCE, V298, P2013, DOI 10.1126/science.1077066
DeRubeis RJ, 2008, NAT REV NEUROSCI, V9, P788, DOI 10.1038/nrn2345
Devlin JT, 2007, NEUROIMAGE, V37, P1033, DOI 10.1016/j.neuroimage.2006.09.055
Di Martino A, 2010, BIOL PSYCHIAT
Dichter G, 2010, 10 ANN INT M AUT RES
Dichter GS, 2010, NEUROCASE, V16, P307, DOI 10.1080/13554790903559671
Dichter GS, 2009, BIOL PSYCHIAT, V66, P886, DOI 10.1016/j.biopsych.2009.06.021
Dichter GS, 2009, SOC COGN AFFECT NEUR, V4, P215, DOI 10.1093/scan/nsp017
Dichter GS, 2010, J AFFECT DISORD
Diederich NJ, 2008, NEUROLOGY, V71, P677, DOI 10.1212/01.wnl.0000324635.49971.3d
Durston S, 2006, DEVELOPMENTAL SCI, V9, P1, DOI 10.1111/j.1467-7687.2005.00454.x
Enck P, 2008, NEURON, V59, P195, DOI 10.1016/j.neuron.2008.06.030
Ernst E, 2007, DRUG DISCOV TODAY, V12, P413, DOI 10.1016/j.drudis.2007.03.007
Evans AC, 2006, NEUROIMAGE, V30, P184, DOI 10.1016/j.neuroimage.2005.09.068
Friedman L, 2008, HUM BRAIN MAPP, V29, P958, DOI 10.1002/hbm.20440
Gaab N, 2007, RESTOR NEUROL NEUROS, V25, P295
Glover GH, 2000, MAGNET RESON MED, V44, P162, DOI 10.1002/1522-2594(200007)44:1<162::AID-MRM23>3.0.CO;2-E
HAJNAL JV, 1994, MAGNET RESON MED, V31, P283, DOI 10.1002/mrm.1910310307
HAMILTON M, 1960, J NEUROL NEUROSUR PS, V23, P56, DOI 10.1136/jnnp.23.1.56
Haut KM, 2010, NEUROPSYCHOPHARMACOL, V35, P1850, DOI 10.1038/npp.2010.52
Hoge RD, 1999, MAGNET RESON MED, V42, P849, DOI 10.1002/(SICI)1522-2594(199911)42:5<849::AID-MRM4>3.0.CO;2-Z
Holcomb HH, 1996, AM J PSYCHIAT, V153, P41
Hunt RH, 2008, DEV PSYCHOPATHOL, V20, P1029, DOI 10.1017/S0954579408000497
Hyder F, 2001, NMR BIOMED, V14, P413, DOI 10.1002/nbm.733
Jezzard P, 1999, MED RADIOLOGY FUNCTI, P173
Kang HC, 2003, NEUROIMAGE, V19, P16, DOI 10.1016/S1053-8119(03)00038-7
Kennedy SH, 2007, AM J PSYCHIAT, V164, P778, DOI 10.1176/appi.ajp.164.5.778
KLONOFF EA, 1986, J BEHAV THER EXP PSY, V17, P189, DOI 10.1016/0005-7916(86)90026-1
Kotsoni E, 2006, J MAGN RESON IMAGING, V23, P877, DOI 10.1002/jmri.20578
KWONG KK, 1992, P NATL ACAD SCI USA, V89, P5675, DOI 10.1073/pnas.89.12.5675
Lehto SM, 2008, PROG NEURO-PSYCHOPH, V32, P229, DOI 10.1016/j.pnpbp.2007.08.013
Leppert IR, 2009, J MAGN RESON IMAGING, V29, P258, DOI 10.1002/jmri.21646
Liu TT, 2002, NEUROIMAGE, V16, P269, DOI 10.1006/nimg.2001.1038
Luna B, 2010, HUM BRAIN MAPP, V31, P863, DOI 10.1002/hbm.21073
Manoach DS, 2001, AM J PSYCHIAT, V158, P955, DOI 10.1176/appi.ajp.158.987.955
March JS, 2005, AM J PSYCHIAT, V162, P836, DOI 10.1176/appi.ajp.162.5.836
Martens MA, 2010, NEUROPSYCHOLOGIA, V48, P2602, DOI 10.1016/j.neuropsychologia.2010.05.007
McGonigle DJ, 2000, NEUROIMAGE, V11, P708, DOI 10.1006/nimg.2000.0562
Oken BS, 2009, NEUROLOGY, V72, P2053, DOI 10.1212/01.wnl.0000349697.25117.41
Passarotti AM, 2010, J AM ACAD CHILD PSY, V49, P1064, DOI 10.1016/j.jaac.2010.07.009
Poldrack RA, 2007, SOC COGN AFFECT NEUR, V2, P67, DOI 10.1093/scan/nsm006
Raemaekers M, 2007, NEUROIMAGE, V36, P532, DOI 10.1016/j.neuroimage.2007.03.061
Raemaekers M, 2011, NEUROIMAGE
Raschle N. M., 2009, J VIS EXP
Restom K, 2008, NEUROIMAGE, V40, P1495, DOI 10.1016/j.neuroimage.2008.01.038
Richards TL, 2008, J NEUROLINGUIST, V21, P294, DOI 10.1016/j.jneuroling.2007.07.002
Sanchez CE, 2012, DEV PSYCHOBIOL, V54, P77, DOI 10.1002/dev.20579
Sears LL, 1999, PROG NEURO-PSYCHOPH, V23, P613, DOI 10.1016/S0278-5846(99)00020-2
Shafritz KM, 2008, BIOL PSYCHIAT, V63, P974, DOI 10.1016/j.biopsych.2007.06.028
Siegle GJ, 2006, AM J PSYCHIAT, V163, P735, DOI 10.1176/appi.ajp.163.4.735
Sikich L, 2001, RES BASIS AUTISM INT
Slifer KJ, 2002, J APPL BEHAV ANAL, V35, P191, DOI 10.1901/jaba.2002.35-191
Small SL, 1998, BRAIN LANG, V62, P298, DOI 10.1006/brln.1998.1951
Specht K, 2003, J MAGN RESON IMAGING, V17, P463, DOI 10.1002/jmri.10277
Summerfelt WT, 1998, PSYCHIATR SERV, V49, P834
Thomas KM, 1999, FUNCTIONAL MRI, P513
Tomarken AJ, 1995, PSYCHOL ASSESSMENT, V7, P387
Tomarken AJ, 1999, HDB RES METHODS CLIN
Trivedi MH, 2006, AM J PSYCHIAT, V163, P28, DOI 10.1176/appi.ajp.163.1.28
van Zijl PCM, 1998, NAT MED, V4, P159, DOI 10.1038/nm0298-159
Voyvodic JT, 1999, NEUROIMAGE, V10, P91, DOI 10.1006/nimg.1999.0457
Waber DP, 2007, J INT NEUROPSYCH SOC, V13, P729, DOI 10.1017/S1355617707070841
Wagner K, 2005, NEUROIMAGE, V28, P122, DOI 10.1016/j.neuroimage.2005.06.005
Webb S, 2010, NAT BIOTECHNOL, V28, P772, DOI 10.1038/nbt0810-772
Wei XC, 2004, NEUROIMAGE, V21, P1000, DOI 10.1016/j.neuroimage.2003.10.039
Wilke M, 2002, HUM BRAIN MAPP, V17, P48, DOI 10.1002/hbm.10053
Yoo SS, 2005, NEUROSCI RES, V53, P84, DOI 10.1016/j.neures.2005.06.004
Yoon U, 2009, NEUROIMAGE, V45, P769, DOI 10.1016/j.neuroimage.2008.12.046
Zandbelt BB, 2008, NEUROIMAGE, V42, P196, DOI 10.1016/j.neuroimage.2008.04.183
Zubieta JK, 2009, ANN NY ACAD SCI, V1156, P198, DOI 10.1111/j.1749-6632.2009.04424.x
NR 91
TC 5
Z9 5
PU INFORMA HEALTHCARE
PI LONDON
PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND
SN 0020-7454
J9 INT J NEUROSCI
JI Int. J. Neurosci.
PD SEP
PY 2012
VL 122
IS 9
BP 483
EP 493
DI 10.3109/00207454.2012.678446
PG 11
WC Neurosciences
SC Neurosciences & Neurology
GA 986QJ
UT WOS:000307358400001
PM 22471393
ER
PT J
AU Sullivan, A
Winograd, G
Verkuilen, J
Fish, MC
AF Sullivan, Alison
Winograd, Greta
Verkuilen, Jay
Fish, Marian C.
TI Children on the Autism Spectrum: Grandmother Involvement and Family
Functioning
SO JOURNAL OF APPLIED RESEARCH IN INTELLECTUAL DISABILITIES
LA English
DT Article
DE autism spectrum disorders; dyadic analysis; family functioning;
grandparents; missing data; multiple imputation procedures
ID CIRCUMPLEX MODEL; GRANDPARENTS; SUPPORT; DISABILITIES; DISORDER;
PARENTS; SYSTEMS; NEEDS
AB Background This study investigated associations between the presence of a child with autism or Aspergers disorder in the family, family functioning and grandmother experiences with the goal of better understanding grandparent involvement in the lives of grandchildren on the autism spectrum and their families. Methods Mothers and grandmothers of children who were either typically developing or on the autism spectrum completed parallel forms of a grandparent involvement measure. Mothers reported on the functioning of the immediate family. Data were analysed via multilevel modelling with mothergrandmother dyads as the unit of observation. Results Autism spectrum disorders in children were associated with more flexible family functioning, lower levels of family satisfaction, greater grandmother difficulties and more grandmother information needs. Conclusions Participation of grandparents in diagnostic and treatment meetings and increased communication among family members may facilitate grandparent support and involvement in families with a child on the autism spectrum.
C1 [Winograd, Greta] SUNY Coll New Platz, Dept Psychol, New Paltz, NY 12561 USA.
[Sullivan, Alison; Verkuilen, Jay] CUNY Grad Sch & Univ Ctr, New York, NY USA.
[Fish, Marian C.] CUNY, Queens Coll, Flushing, NY USA.
RP Winograd, G (reprint author), SUNY Coll New Platz, Dept Psychol, 600 Hawk Dr, New Paltz, NY 12561 USA.
EM winograg@newpaltz.edu
CR Altiere MJ, 2009, J CHILD FAM STUD, V18, P83, DOI 10.1007/s10826-008-9209-y
American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th
Anderson C., 2010, INTERACTIVE AUTISM 1
BARNES HL, 1985, CHILD DEV, V56, P438, DOI 10.1111/j.1467-8624.1985.tb00118.x
Beebe D. W., 2003, COGNITIVE THERAPY CH, P369
COLLINSWORTH P, 1991, EDUC PSYCHOL MEAS, V51, P785, DOI 10.1177/0013164491513030
Ekas NV, 2010, J AUTISM DEV DISORD, V40, P1274, DOI 10.1007/s10803-010-0986-y
Gallagher PA, 2010, TOP EARLY CHILD SPEC, V30, P56, DOI 10.1177/0271121409360826
GEORGE JD, 1988, MENT RETARD, V26, P369
Green SE, 2001, INT J AGING HUM DEV, V53, P11, DOI 10.2190/Q7M2-LE06-JLDL-GNWF
HARRIS SL, 1985, J AUTISM DEV DISORD, V15, P127, DOI 10.1007/BF01531599
Hastings RP, 2002, J APPL RES INTELLECT, V15, P97, DOI 10.1046/j.1360 2322.2001.00097.x
Heller T., 2000, J GERONTOLOGICAL SOC, V33, P22
Hillman J, 2007, EDUC GERONTOL, V33, P513, DOI 10.1080/03601270701328425
Hornby G, 1994, J CHILD FAM STUD, V3, P403, DOI 10.1007/BF02233999
Janickis MP, 2000, J GERONTOLOGICAL SOC, V33, P35
Katz Shira, 2002, Issues Compr Pediatr Nurs, V25, P113, DOI 10.1080/01460860290042530
Kenny D. A., 2006, DYADIC DATA ANAL
Lee M, 2010, EDUC GERONTOL, V36, P467, DOI 10.1080/03601270903212419
Margetts JK, 2006, CHILD CARE HLTH DEV, V32, P565, DOI 10.1111/j.1365-2214.2006.00671.x
Mirfin-Veitch B., 1996, NZ J DISABILITY STUD, V2, P136
Mitchell W., 2008, SUPPORT LEARNING, V23, P126, DOI 10.1111/j.1467-9604.2008.00383.x
Olson D. H., 1995, FAMILY SATISFACTION
Olson DH, 2000, J FAM THER, V22, P144, DOI 10.1111/1467-6427.00144
OLSON DH, 1979, FAM PROCESS, V18, P3, DOI 10.1111/j.1545-5300.1979.00003.x
Olson D.H., 2007, FACES 4 MANUAL LIFE
Royston P, 2009, STATA J, V9, P252
SELIGMAN M, 1991, FAM SOC-J CONTEMP H, V72, P147
Silverstein M, 2001, J FAM ISSUES, V22, P493, DOI 10.1177/019251301022004006
Sivberg Bengt, 2002, Int J Circumpolar Health, V61 Suppl 2, P36
Somary K, 1998, GERONTOLOGIST, V38, P53
StataCorp, 2009, STAT STAT SOFTW REL
Strom R, 1997, INT J AGING HUM DEV, V45, P255, DOI 10.2190/HAVE-HWKU-6BCG-9EY5
Strom R., 1993, GRANDPARENT STRENGTH
Trute B, 2003, FAM SOC-J CONTEMP H, V84, P119
Uhlenberg P, 1998, GERONTOLOGIST, V38, P276
NR 36
TC 5
Z9 5
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1360-2322
J9 J APPL RES INTELLECT
JI J. Appl. Res. Intellect. Disabil.
PD SEP
PY 2012
VL 25
IS 5
BP 484
EP 494
DI 10.1111/j.1468-3148.2012.00695.x
PG 11
WC Psychology, Educational; Rehabilitation
SC Psychology; Rehabilitation
GA 989KM
UT WOS:000307558700010
PM 22890949
ER
PT J
AU Bussing, R
Porter, P
Zima, BT
Mason, D
Garvan, C
Reid, R
AF Bussing, Regina
Porter, Phillip
Zima, Bonnie T.
Mason, Dana
Garvan, Cynthia
Reid, Robert
TI Academic Outcome Trajectories of Students With ADHD: Does Exceptional
Education Status Matter?
SO JOURNAL OF EMOTIONAL AND BEHAVIORAL DISORDERS
LA English
DT Article
DE academic achievement; failure; ADHD; autism disorders; disabilities;
learning disorders
ID ATTENTION-DEFICIT/HYPERACTIVITY-DISORDER; DEFICIT HYPERACTIVITY
DISORDER; PSYCHOMETRIC PROPERTIES; SCHOOL PERFORMANCE; CHILDREN;
ACHIEVEMENT; SYMPTOMS; ADOLESCENTS; IMPACT; DISTURBANCES
AB Attention-deficit/hyperactivity disorder (ADHD) has been associated with poor academic performance, but little is known about learning trajectories and risk factors for poor academic outcomes. This study investigates the relationship between ADHD and academic performance in students with ADHD (n = 87), students with subclinical ADHD (n = 23), and matched comparisons (n = 112), accounting for exceptional student education (ESE) status. Academic outcomes included reading and math scores on a state-mandated achievement test, the Florida Comprehensive Assessment Test (FCAT), grade point averages, retention, and graduation. Cross-sectional and longitudinal analyses were conducted, adjusting for sociodemographic characteristics and ESE, to test ADHD status as an independent outcome predictor. Students with ADHD received more special education services (53%) than subclinical (26%) and comparison (10%) students (p < .01). ADHD was associated with poorer academic performance on all outcome measures, but only when ESE status was not accounted for. In the longitudinal analysis students with ADHD and special education needs consistently achieved lower FCAT scores than peers in the comparison group but showed comparable learning gains, or slopes, over time. Students without special education needs and gifted students with ADHD had comparable achievement and learning gains as comparison students of the same ESE status. Results suggest that special education status is a driving factor in underachievement among students with ADHD.
C1 [Bussing, Regina; Mason, Dana] Univ Florida, Coll Med, Dept Psychiat, Gainesville, FL 32610 USA.
[Zima, Bonnie T.] Univ Calif Los Angeles, Dept Psychiat & Biobehav Sci, UCLA David Geffen Sch Med, Los Angeles, CA USA.
[Reid, Robert] Univ Nebraska Lincoln, Dept Special Educ & Commun Disorders, Lincoln, NE USA.
[Garvan, Cynthia] Univ Florida, Coll Educ, Sch Human Dev & Org Sci, Gainesville, FL 32610 USA.
RP Bussing, R (reprint author), Univ Florida, Coll Med, Dept Psychiat, Box 100234 UFHSC, Gainesville, FL 32610 USA.
EM rbussing@ufl.edu
CR Alloway TP, 2009, CHILD DEV, V80, P606, DOI 10.1111/j.1467-8624.2009.01282.x
American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th
Anderson J., 2001, J EMOT BEHAV DISORD, V9, P105, DOI [10.1177/106342660100900205, DOI 10.1177/106342660100900205]
Antshel KM, 2007, J CHILD PSYCHOL PSYC, V48, P687, DOI 10.1111/j.1469-7610.2007.01735.x
Barkley RA, 2006, ATTENTION DEFICIT HY, P122
Barry TD, 2002, J SCHOOL PSYCHOL, V40, P259, DOI 10.1016/S0022-4405(02)00100-0
Bauermeister JJ, 2007, J ABNORM CHILD PSYCH, V35, P883, DOI 10.1007/s10802-007-9141-4
Breslau J, 2009, PEDIATRICS, V123, P1472, DOI 10.1542/peds.2008-1406
Bussing R, 2008, ASSESSMENT, V15, P317, DOI 10.1177/1073191107313888
Bussing R, 1998, BEHAV DISORDERS, V23, P85
Bussing R, 2003, J BEHAV HEALTH SER R, V30, P176, DOI 10.1007/BF02289806
Coutinho M., 1986, BEHAV DISORDERS, V11, P200
Currie J, 2006, J HEALTH ECON, V25, P1094, DOI 10.1016/j.jhealeco.2006.03.001
Diamantopoulou S, 2007, DEV NEUROPSYCHOL, V32, P521
Faraone S. V., 2001, J ATTEN DISORD, V4, P220, DOI [10.1177/108705470100400404, DOI 10.1177/108705470100400404]
Frazier TW, 2004, NEUROPSYCHOLOGY, V18, P543, DOI 10.1037/0894-4105.18.3.543
Frazier TW, 2007, J LEARN DISABIL-US, V40, P49, DOI 10.1177/00222194070400010401
Galera C, 2009, PSYCHOL MED, V39, P1895, DOI 10.1017/S0033291709005510
Gureasko-Moore S, 2006, BEHAV MODIF, V30, P159, DOI 10.1177/0145445503259387
Hollingshead A. B., 1975, 4 FACTOR INDEX SOCIA
Kaufman J, 1997, J AM ACAD CHILD PSY, V36, P980, DOI 10.1097/00004583-199707000-00021
Langberg JM, 2008, J CLIN CHILD ADOLESC, V37, P651, DOI 10.1080/15374410802148095
Loe IM, 2007, AMBUL PEDIATR, V7, P82, DOI 10.1016/j.ambp.2006.05.005
Lopez M. F., 1998, ED TREATMENT CHILDRE, V19, P286
Mandell DS, 2008, J EMOT BEHAV DISORD, V16, P42, DOI 10.1177/1063426607310848
Massetti GM, 2008, J ABNORM CHILD PSYCH, V36, P399, DOI 10.1007/s10802-007-9186-4
MCCONAUGHY SH, 1994, SCHOOL PSYCHOL REV, V23, P81
Molina BSG, 2009, J AM ACAD CHILD PSY, V48, P484, DOI 10.1097/CHI.0b013e31819c23d0
Murray DW, 2009, ASSESSMENT, V16, P193, DOI 10.1177/1073191108326924
Rabiner D, 2000, J AM ACAD CHILD PSY, V39, P859, DOI 10.1097/00004583-200007000-00014
Reid R, 2005, EXCEPT CHILDREN, V71, P361
REID R, 1994, J SPEC EDUC, V28, P117
REID R, 1995, REM SPEC EDUC, V16, P44
Rogevich ME, 2008, EXCEPT CHILDREN, V74, P135
Scheffler RM, 2009, PEDIATRICS, V123, P1273, DOI 10.1542/peds.2008-1597
Schnoes C, 2006, EXCEPT CHILDREN, V72, P483
SCHWABSTONE M, 1994, AM J PSYCHIAT, V151, P1048
Swanson JM, 2001, J AM ACAD CHILD PSY, V40, P168, DOI 10.1097/00004583-200102000-00011
Wolraich ML, 2003, J PEDIATR PSYCHOL, V28, P559, DOI 10.1093/jpepsy/jsg046
NR 39
TC 4
Z9 4
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1063-4266
J9 J EMOT BEHAV DISORD
JI J. Emot. Behav. Disord.
PD SEP
PY 2012
VL 20
IS 3
BP 131
EP 143
DI 10.1177/1063426610388180
PG 13
WC Education, Special; Psychology, Educational; Psychology,
Multidisciplinary
SC Education & Educational Research; Psychology
GA 990PO
UT WOS:000307643200001
ER
PT J
AU de Souza, MBR
de Oliveira, JRM
AF Rodrigues de Souza, Manuela Barbosa
Mendes de Oliveira, Joao Ricardo
TI Searching for New Genetic Variations in Expression Databases for the
GABAergic and Glutamatergic Systems
SO JOURNAL OF MOLECULAR NEUROSCIENCE
LA English
DT Article
DE Genetic variations; Neurogenetics; Mood disorders; Bioinformatics;
Microarrays; Expressed sequence tag
ID BIOINFORMATICS TOOLS; BIPOLAR DISORDER; MAJOR DEPRESSION; MOOD
DISORDERS; HUMAN GENOME; MUTATIONS; POLYMORPHISM; ASSOCIATION; AUTISM;
GABA
AB Changes in gene expression and genetic variations in coding regions have likely functional impact, potentially associated with complex diseases, such as neuropsychiatric conditions. A current need for high throughput analysis of genomic data is leading to the development and improvement of sophisticated bioinformatics approaches, which allows the processing of large amounts of sequence and gene expression data. In this study, we identified new potential genetic variations prioritizing genes related to glutamatergic and GABAergic systems, using different bioinformatics resources. The CLCbio Workbench Combined platform was initially used to build expressed sequence tags and mRNA files retrieved, respectively, from the Goldenpath and National Center for Biotechnology Information databases and latter to perform multiple batches of Smith-Waterman alignments. The PMUT software was used to increase an accurate association between potential variations and pathogenic predictions. The annotation revealed various classes of variations and most of them are deletions ranging from 1 to 7 bp. Bioinformatic pipelines seem to be useful approaches to help screening for genetic variations with potential impact in gene expression. Further analysis will foster this aim to provide celerity at the massive analysis of data currently generated in large scale high throughput experiments.
C1 [Mendes de Oliveira, Joao Ricardo] Fed Univ Pernambuco UFPE, Dept Neuropsychiat, BR-50670901 Recife, PE, Brazil.
[Rodrigues de Souza, Manuela Barbosa; Mendes de Oliveira, Joao Ricardo] Fed Univ Pernambuco UFPE, Keizo Asami Lab LIKA, BR-50670901 Recife, PE, Brazil.
RP de Oliveira, JRM (reprint author), Fed Univ Pernambuco UFPE, Dept Neuropsychiat, BR-50670901 Recife, PE, Brazil.
EM manu.brsouza@gmail.com; joao.ricardo@ufpe.br
FU LIKA-JIKA; PROPESQ-UFPE; CAPES; CNPq; FACEPE
FX We are greatly indebted to Henrique Castelletti and Roberta Rodrigues de
Lemos for their technical support. This study received financial support
from the following Brazilian funding agencies and academic bureaus:
LIKA-JIKA, PROPESQ-UFPE, CAPES, CNPq, and FACEPE.
CR Buxbaum JD, 2002, MOL PSYCHIATR, V7, P311, DOI 10.1038/sj/mp/4001011
Capriotti E, 2006, BIOINFORMATICS, V22, P2729, DOI 10.1093/bioinformatics/btl423
Choi KH, 2011, BIOL PSYCHIAT, V69, P353, DOI 10.1016/j.biopsych.2010.09.042
Choudary PV, 2005, P NATL ACAD SCI USA, V102, P15653, DOI 10.1073/pnas.0507901102
Craddock N, 2010, MOL PSYCHIATR, V15, P146, DOI 10.1038/mp.2008.66
DeLong R, 2004, J NEUROPSYCH CLIN N, V16, P199, DOI 10.1176/appi.neuropsych.16.2.199
de Souza MBR, 2010, J MOL NEUROSCI, V41, P193, DOI 10.1007/s12031-009-9321-5
Ferrer-Costa C, 2004, PROTEINS, V57, P811, DOI 10.1002/prot.20252
Ferrer-Costa C, 2005, PROTEINS, V61, P878, DOI 10.1002/prot.20664
Feuk L, 2006, NAT REV GENET, V7, P85, DOI 10.1038/nrg1767
Iwamoto K, 2004, MOL PSYCHIATR, V9, P406, DOI 10.1038/sj.mp.4001437
Karolewicz B, 2010, INT J NEUROPSYCHOPH, V13, P411, DOI 10.1017/S1461145709990587
Krystal JH, 2002, MOL PSYCHIATR, V7, pS71, DOI 10.1038/sj.mp.4001021
Lemos R, 2009, J MOL NEUROSCI, V39, P241
Lemos RR, 2011, J MOL NEUROSCI, V43, P333, DOI 10.1007/s12031-010-9445-7
Luscher B, 2011, MOL PSYCHIATR, V16, P383, DOI 10.1038/mp.2010.120
Macintyre G, 2010, BIOINFORMATICS, V26, P524
Merali Z, 2004, J NEUROSCI, V24, P1478, DOI 10.1523/JNEUROSCI.4734-03.2004
Mooney S, 2005, BRIEF BIOINFORM, V6, P44, DOI 10.1093/bib/6.1.44
Oliveira JRM, 2000, MOL PSYCHIATR, V5, P348, DOI 10.1038/sj.mp.4000725
Panitz F, 2007, BIOINFORMATICS, V23, P387
Reumers J, 2009, BMC BIOINFORMATICS, V10, DOI 10.1186/1471-2105-10-S8-S9
Rosenfeld JA, 2010, NUCLEIC ACIDS RES, V38, P6102, DOI 10.1093/nar/gkq408
Rudolph U, 2011, NAT REV DRUG DISCOV, V10, P1
Sanacora G, 2008, NAT REV DRUG DISCOV, V7, P426, DOI 10.1038/nrd2462
Schousboe A, 2007, PROG BRAIN RES, V160, P9, DOI 10.1016/S0079-6123(06)60002-2
Sequeira A, 2009, PLOS ONE, V4, P65
Shen QY, 2010, BIOL PSYCHIAT, V68, P512, DOI 10.1016/j.biopsych.2010.04.024
SMITH TF, 1981, J MOL BIOL, V147, P195, DOI 10.1016/0022-2836(81)90087-5
Teufel A, 2006, INT J MOL MED, V17, P967
Togsverd M, 2008, J AFFECT DISORDERS, V106, P169, DOI 10.1016/j.jad.2007.06.010
Tsunoka T, 2009, PROG NEURO-PSYCHOPH, V33, P875, DOI 10.1016/j.pnpbp.2009.04.007
NR 32
TC 0
Z9 0
PU HUMANA PRESS INC
PI TOTOWA
PA 999 RIVERVIEW DRIVE SUITE 208, TOTOWA, NJ 07512 USA
SN 0895-8696
J9 J MOL NEUROSCI
JI J. Mol. Neurosci.
PD SEP
PY 2012
VL 48
IS 1
BP 257
EP 264
DI 10.1007/s12031-012-9771-z
PG 8
WC Biochemistry & Molecular Biology; Neurosciences
SC Biochemistry & Molecular Biology; Neurosciences & Neurology
GA 986HZ
UT WOS:000307334000028
PM 22528461
ER
PT J
AU Smith, SEP
Elliott, RM
Anderson, MP
AF Smith, Stephen E. P.
Elliott, Robin M.
Anderson, Matthew P.
TI Maternal Immune Activation Increases Neonatal Mouse Cortex Thickness and
Cell Density
SO JOURNAL OF NEUROIMMUNE PHARMACOLOGY
LA English
DT Article
ID ADULT SCHIZOPHRENIA; PRENATAL EXPOSURE; AUTISM; BRAIN; INFECTION;
PATHOLOGY
C1 [Smith, Stephen E. P.; Elliott, Robin M.; Anderson, Matthew P.] Harvard Univ, Sch Med, Dept Neurol, Boston, MA 02215 USA.
[Smith, Stephen E. P.; Elliott, Robin M.; Anderson, Matthew P.] Beth Israel Deaconess Med Ctr, Ctr Life Sci, Boston, MA 02215 USA.
[Smith, Stephen E. P.; Elliott, Robin M.; Anderson, Matthew P.] Harvard Univ, Sch Med, Dept Pathol, Boston, MA 02215 USA.
RP Anderson, MP (reprint author), Harvard Univ, Sch Med, Dept Neurol, 330 Brookline Ave,E CLS-717, Boston, MA 02215 USA.
EM mpanders@bidmc.harvard.edu
FU National Institute of Neurological Disorders and Stroke [R01
NS057444-01A2]; Nancy Lurie Marks Family Foundation; Autism Speaks/NAAR;
Beth Israel Deaconess Medical Center
FX This work was supported in part by the National Institute of
Neurological Disorders and Stroke R01 NS057444-01A2 (M. P. A.), the
Nancy Lurie Marks Family Foundation (M. P. A.), Autism Speaks/NAAR (M.
P. A.), and Beth Israel Deaconess Medical Center. The authors declare
that they have no conflict of interest.
CR Atladottir HO, 2010, J AUTISM DEV DISORD, V40, P1423, DOI 10.1007/s10803-010-1006-y
Babulas V, 2006, AM J PSYCHIAT, V163, P927, DOI 10.1176/appi.ajp.163.5.927
Brown AS, 2002, MENT RETARD DEV D R, V8, P51, DOI 10.1002/mrdd.10004
Brown Alan S, 2011, Front Psychiatry, V2, P63, DOI 10.3389/fpsyt.2011.00063
Brown AS, 2005, AM J PSYCHIAT, V162, P767, DOI 10.1176/appi.ajp.162.4.767
Casanova MF, 2009, PHILOS T R SOC B, V364, P1433, DOI 10.1098/rstb.2008.0331
CHESS S, 1977, J AUTISM CHILD SCHIZ, V7, P69, DOI 10.1007/BF01531116
CIARANELLO AL, 1995, ANNU REV NEUROSCI, V18, P101
Courchesne E, 2011, JAMA-J AM MED ASSOC, V306, P2001, DOI 10.1001/jama.2011.1638
Hsiao EY, 2011, BRAIN BEHAV IMMUN, V25, P604, DOI 10.1016/j.bbi.2010.12.017
MEDNICK SA, 1988, ARCH GEN PSYCHIAT, V45, P189
Meyer U, 2008, BRAIN BEHAV IMMUN, V22, P469, DOI 10.1016/j.bbi.2007.09.012
Patterson PH, 2009, BEHAV BRAIN RES, V204, P313, DOI 10.1016/j.bbr.2008.12.016
Schumann CM, 2010, BRAIN RES, V1380, P175
Shi LM, 2009, BRAIN BEHAV IMMUN, V23, P116, DOI 10.1016/j.bbi.2008.07.012
Smith SEP, 2007, J NEUROSCI, V27, P10695, DOI 10.1523/JNEUROSCI.2178-07.2007
Vargas DL, 2005, ANN NEUROL, V57, P67, DOI 10.1002/ana.20315
Voineagu I, 2011, NATURE, V474, P380, DOI 10.1038/nature10110
NR 18
TC 1
Z9 1
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1557-1890
J9 J NEUROIMMUNE PHARM
JI J. Neuroimmune Pharm.
PD SEP
PY 2012
VL 7
IS 3
BP 529
EP 532
DI 10.1007/s11481-012-9372-1
PG 4
WC Neurosciences; Pharmacology & Pharmacy
SC Neurosciences & Neurology; Pharmacology & Pharmacy
GA 989JL
UT WOS:000307556000004
PM 22570011
ER
PT J
AU Holwerda, A
van der Klink, JJL
Groothoff, JW
Brouwer, S
AF Holwerda, Anja
van der Klink, Jac J. L.
Groothoff, Johan W.
Brouwer, Sandra
TI Predictors for Work Participation in Individuals with an Autism Spectrum
Disorder: A Systematic Review
SO JOURNAL OF OCCUPATIONAL REHABILITATION
LA English
DT Review
DE Autism; Work participation; Predictors
ID QUALITY-OF-LIFE; FOLLOW-UP; ASPERGER-SYNDROME; INTELLECTUAL DISABILITY;
YOUNG-ADULTS; SUPPORTED-EMPLOYMENT; PROGNOSTIC-FACTORS; CHILDREN;
PEOPLE; LANGUAGE
AB Introduction Research shows that only about 25% of people with autism are employed. Method We conducted a systematic review on factors facilitating or hindering work participation of people with autism in longitudinal studies. An extensive search in biomedical and psychological databases yielded 204 articles and 18 satisfied all inclusion criteria. We assessed the methodological quality of included studies using an established criteria list. Results Seventeen factors were identified and categorized as disease-related factors, personal factors or external factors. Limited cognitive ability was the only significant predictor consistently found for work outcome. Functional independence and institutionalization were both reported by one study to be significantly related to work outcome. Inconsistent findings or non significant findings were reported for the other fourteen factors. Conclusion These findings emphasize the need for more high quality cohort studies focussing on work participation as the main outcome among people with Autism.
C1 [Holwerda, Anja; van der Klink, Jac J. L.; Groothoff, Johan W.; Brouwer, Sandra] Univ Groningen, Dept Hlth Sci Community & Occupat Med, Univ Med Ctr Groningen, NL-9700 AD Groningen, Netherlands.
RP Holwerda, A (reprint author), Univ Groningen, Dept Hlth Sci Community & Occupat Med, Univ Med Ctr Groningen, Bldg 3217,Room 621,Antonius Deusinglaan 1, NL-9713 AV Groningen, Netherlands.
EM a.holwerda@med.umcg.nl
CR Altman DG, 2001, BRIT MED J, V323, P224, DOI 10.1136/bmj.323.7306.224
BallabanGil K, 1996, PEDIATR NEUROL, V15, P217, DOI 10.1016/S0887-8994(96)00219-6
Beadle-Brown J, 2005, AM J MENT RETARD, V110, P1, DOI 10.1352/0895-8017(2005)110<1:LOFPWS>2.0.CO;2
Billstedt E, 2011, AUTISM, V15, P7, DOI 10.1177/1362361309346066
Cederlund M, 2008, J AUTISM DEV DISORD, V38, P72, DOI 10.1007/s10803-007-0364-6
Cornelius LR, 2011, J OCCUP REHABIL, V21, P259, DOI 10.1007/s10926-010-9261-5
Dusseljee JCE, 2011, J INTELL DISABIL RES, V55, P4, DOI 10.1111/j.1365-2788.2010.01342.x
Eaves LC, 2008, J AUTISM DEV DISORD, V38, P739, DOI 10.1007/s10803-007-0441-x
Edwards J., 1991, INT REV IND ORG PSYC, P283
Edwards J. R., 2007, PERSPECTIVES ORG FIT, P209
Eggleton I., 1999, J VOCATIONAL REHABIL, V13, P95
Farley MA, 2009, AUTISM RES, V2, P109, DOI 10.1002/aur.69
Fombonne E, 1989, Acta Paedopsychiatr, V52, P12
Garcia-Villamisar D, 2000, J VOCATIONAL REHABIL, V14, P183
Garcia-Villamisar D., 2002, J VOCATIONAL REHABIL, V17, P309
GILLBERG C, 1991, J AM ACAD CHILD PSY, V30, P375, DOI 10.1097/00004583-199105000-00004
Gillberg C, 1998, BRIT J PSYCHIAT, V172, P200, DOI 10.1192/bjp.172.3.200
GILLBERG C, 1991, BRIT J PSYCHIAT, V158, P403, DOI 10.1192/bjp.158.3.403
Howlin P, 2003, J AUTISM DEV DISORD, V33, P3, DOI 10.1023/A:1022270118899
Howlin P, 2000, J CHILD PSYCHOL PSYC, V41, P561, DOI 10.1017/S0021963099005806
Howlin P, 2000, AUTISM, V4, P63, DOI DOI 10.1177/1362361300004001005
Howlin P, 2004, J CHILD PSYCHOL PSYC, V45, P212, DOI 10.1111/j.1469-7610.2004.00215.x
Hume K, 2009, J AUTISM DEV DISORD, V39, P1329, DOI 10.1007/s10803-009-0751-2
Jennes-Coussens M, 2006, AUTISM, V10, P403, DOI 10.1177/1362361306064432
Kirsh B, 2009, WORK, V32, P391, DOI 10.3233/WOR-2009-0851
KOBAYASHI R, 1992, J AUTISM DEV DISORD, V22, P395, DOI 10.1007/BF01048242
Kogan MD, 2009, PEDIATRICS, V124, P1395, DOI 10.1542/peds.2009-1522
Lagerveld SE, 2010, J OCCUP REHABIL, V20, P275, DOI 10.1007/s10926-009-9224-x
Lanier I., 2011, J CONTEMP PSYCHOTHER, V41, P37, DOI 10.1007/s10879-010-9160-2
Larsen FW, 1997, EUR CHILD ADOLES PSY, V6, P181
Lawer L, 2009, J AUTISM DEV DISORD, V39, P487, DOI 10.1007/s10803-008-0649-4
LOTTER V, 1974, J AUTISM CHILD SCHIZ, V4, P11, DOI 10.1007/BF02104997
Magill-Evans J, 2008, WORK, V31, P433
Mawhood L, 1999, AUTISM INT J RES PRA, V3, P229, DOI DOI 10.1177/1362361399003003003
McGrew JH, 2005, PSYCHIATR REHABIL J, V29, P41, DOI 10.2975/29.2005.41.47
Nonkin Avchen R, 2011, J AUTISM DEV DISORD, V41, P227
Nordin V, 1998, ACTA PSYCHIAT SCAND, V97, P99, DOI 10.1111/j.1600-0447.1998.tb09970.x
Parmenter T R, 1991, Int J Rehabil Res, V14, P281, DOI 10.1097/00004356-199112000-00001
Ridley J., 2006, J VOCAT REHABIL, V25, P57
Ruble L. A., 1996, FOCUS AUTISM OTHER D, V11, P3
RUMSEY JM, 1985, J AM ACAD CHILD PSY, V24, P465, DOI 10.1016/S0002-7138(09)60566-5
RUTTER M, 1970, SEMIN PSYCHIAT, V2, P435
RUTTER M, 1967, BRIT J PSYCHIAT, V113, P1183, DOI 10.1192/bjp.113.504.1183
Schneider J, 2008, DISABIL REHABIL, V30, P1819, DOI 10.1080/09638280701661257
Scholten-Peeters GGM, 2003, PAIN, V104, P303, DOI 10.1016/S0304-3959(03)00050-2
SZATMARI P, 1989, J AUTISM DEV DISORD, V19, P213, DOI 10.1007/BF02211842
Taylor JL, 2011, J AUTISM DEV DISORD, V41, P566, DOI 10.1007/s10803-010-1070-3
Ustun TB, 2003, DISABIL REHABIL, V25, P565, DOI 10.1080/0963828031000137063
UWV, 2009, UWV KWART 2009 3
Verdonschot MML, 2009, J INTELL DISABIL RES, V53, P303, DOI 10.1111/j.1365-2788.2008.01144.x
Vila M, 2007, J INTELLECT DEV DIS, V32, P10, DOI 10.1080/13668250701196807
Volkmar FR, 2009, J CHILD PSYCHOL PSYC, V50, P108, DOI 10.1111/j.1469-7610.2008.02010.x
Waddell Gordon, 2007, J Insur Med, V39, P109
Whitehouse AJO, 2009, INT J LANG COMM DIS, V44, P511, DOI 10.1080/13682820802708098
Achterberg TJ, 2009, J OCCUP REHABIL, V19, P129, DOI 10.1007/s10926-009-9169-0
WOLF L, 1986, CAN J PSYCHIAT, V31, P550
World Health Organisation, 2001, INT CLASS FUNCT DIS
NR 57
TC 8
Z9 8
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1053-0487
J9 J OCCUP REHABIL
JI J. Occup. Rehabil.
PD SEP
PY 2012
VL 22
IS 3
BP 333
EP 352
DI 10.1007/s10926-011-9347-8
PG 20
WC Rehabilitation; Social Issues
SC Rehabilitation; Social Issues
GA 985MA
UT WOS:000307269500006
PM 22270229
ER
PT J
AU Shen, MD
Shih, P
Ottl, B
Keehn, B
Leyden, KM
Gaffrey, MS
Muller, RA
AF Shen, Mark D.
Shih, Patricia
Oettl, Birgit
Keehn, Brandon
Leyden, Kelly M.
Gaffrey, Michael S.
Mueller, Ralph-Axel
TI Atypical lexicosemantic function of extrastriate cortex in autism
spectrum disorder: Evidence from functional and effective connectivity
SO NEUROIMAGE
LA English
DT Article
DE Lexical; Semantic; Visual; Functional connectivity; Structural equation
modeling; Autism
ID STRUCTURAL EQUATION; RESTING-STATE; SENTENCE COMPREHENSION;
ASPERGERS-SYNDROME; CORPUS-CALLOSUM; VISUAL-CORTEX; WHITE-MATTER;
MR-IMAGES; FMRI DATA; BRAIN
AB Previous studies have suggested atypically enhanced activity of visual cortex during language processing in autism spectrum disorder (ASD). However, it remains unclear whether visual cortical participation reflects isolated processing within posterior regions or functional cooperation with distal brain regions, such as left inferior frontal gyrus (LIFG). We addressed this question using functional connectivity MRI (fcMRI) and structural equation modeling in 14 adolescents and adults with ASD and 14 matched typically developing (TD) participants. Data were analyzed to isolate low-frequency intrinsic fluctuations, by regressing out effects of a semantic decision task. For a right extrastriate seed derived from the strongest cluster of atypical activation in the ASD group, widespread effects of increased connectivity in prefrontal and medial frontal lobes bilaterally were observed for the ASD group, compared to the TD group. A second analysis for a seed in LIFG, derived from pooled activation effects in both groups, also yielded widespread effects of overconnectivity in the ASD group, especially in temporal lobes. Structural equation modeling showed that whereas right extrastriate cortex did not impact function of language regions (left and right IFG, left middle temporal gyrus) in the TD model, it was an integral part of a language circuit in the ASD group. These results suggest that atypical extrastriate activation during language processing in ASD reflects integrative (not isolated) processing. Furthermore, our findings are inconsistent with previous reports of functional underconnectivity in ASD, probably related to removal of task effects required to isolate intrinsic low-frequency fluctuations. (c) 2012 Elsevier Inc. All rights reserved.
C1 [Shen, Mark D.; Shih, Patricia; Oettl, Birgit; Keehn, Brandon; Leyden, Kelly M.; Gaffrey, Michael S.; Mueller, Ralph-Axel] San Diego State Univ, Dept Psychol, Brain Dev Imaging Lab, San Diego, CA 92120 USA.
[Shen, Mark D.] Univ Calif Davis, MIND Inst, UC Davis Sch Med, Sacramento, CA 95817 USA.
[Shih, Patricia] Brown Univ, Dept Neurosci, Providence, RI 02912 USA.
[Oettl, Birgit] Univ Tubingen, Dept Psychol, D-72074 Tubingen, Germany.
[Keehn, Brandon] San Diego State Univ, Joint Doctoral Program Language & Communicat Diso, San Diego, CA 92182 USA.
[Keehn, Brandon] Univ Calif San Diego, San Diego, CA 92103 USA.
[Keehn, Brandon] Harvard Univ, Childrens Hosp, Sch Med, Boston, MA 02115 USA.
[Gaffrey, Michael S.] Washington Univ, Sch Med, Dept Psychiat, St Louis, MO 63110 USA.
[Shen, Mark D.] Univ Calif Davis, UC Davis Sch Med, Dept Psychiat & Behav Sci, Sacramento, CA 95817 USA.
RP Muller, RA (reprint author), San Diego State Univ, Dept Psychol, Brain Dev Imaging Lab, 6363 Alvarado Ct,Suite 200, San Diego, CA 92120 USA.
EM amueller@sciences.sdsu.edu
FU National Institutes of Health [R01-DC006155, R01-MH081023]; National
Institute on Deafness and Other Communicative Disorders, NIDCD
[1T32DC007361-03]
FX This study was supported by the National Institutes of Health,
R01-DC006155 and R01-MH081023, with additional funding from the National
Institute on Deafness and Other Communicative Disorders, NIDCD
1T32DC007361-03 (author BK). Special thanks to the participants and
families who participated and to Frank Haist, Gang Chen, Wesley
Thompson, Ben McKenna, and Aaron Lee for their help and insight on fcMRI
and SEM analysis.
CR Agam Y, 2010, NEUROIMAGE, V52, P336, DOI 10.1016/j.neuroimage.2010.04.010
Alexander AL, 2007, NEUROIMAGE, V34, P61, DOI 10.1016/j.neuroimage.2006.08.032
Alvarez RP, 2008, J NEUROSCI, V28, P6211, DOI 10.1523/JNEUROSCI.1246-08.2008
American Psychiatric Association, 2000, DIAGN STAT MAN MENT
Auer DP, 2008, MAGN RESON IMAGING, V26, P1055, DOI 10.1016/j.mri.2008.05.008
Beckmann CF, 2005, PHILOS T ROY SOC B, V360, P1001, DOI 10.1098/rstb.2005.1634
BENTLER PM, 1990, PSYCHOL BULL, V107, P238, DOI 10.1037//0033-2909.107.2.238
BISWAL B, 1995, MAGNET RESON MED, V34, P537, DOI 10.1002/mrm.1910340409
Biswal BB, 2010, P NATL ACAD SCI USA, V107, P4734, DOI 10.1073/pnas.0911855107
Black J., 1998, HDB CHILD ADOLESCENT, V4, P31
Boucher J, 2012, J CHILD PSYCHOL PSYC, V53, P219, DOI 10.1111/j.1469-7610.2011.02508.x
Brown TT, 2005, CEREB CORTEX, V15, P275, DOI 10.1093/cercor/bhh129
Browne MW, 1993, TESTING STRUCTURAL E, P136, DOI DOI 10.1177/0049124192021002001
Buchel C, 1997, CEREB CORTEX, V7, P768, DOI 10.1093/cercor/7.8.768
Bullmore ET, 2000, NEUROIMAGE, V11, P289, DOI 10.1006/nimg.2000.0544
Bullmore ET, 2009, NAT REV NEUROSCI, V10, P186, DOI 10.1038/nrn2575
Carter A., 2005, HDB AUTISM PERVASIVE, P312
Chaminade T, 2003, EUR J NEUROSCI, V18, P675, DOI 10.1046/j.1460-9568.2003.02787.x
Chawarska K, 2005, HDB AUTISM PERVASIVE, P223
Chen G., 2007, HUM BRAIN MAPP C CHI
Cordes D, 2000, AM J NEURORADIOL, V21, P1636
Cordes D, 2001, AM J NEURORADIOL, V22, P1326
Courchesne E, 2001, NEUROLOGY, V57, P245
Dakin S, 2005, NEURON, V48, P497, DOI 10.1016/j.neuron.2005.10.018
de Marco G, 2009, MAGN RESON IMAGING, V27, P1, DOI 10.1016/j.mri.2008.05.003
Dunn M, 1996, CHILD NEUROPSYCHOL, V2, P99, DOI 10.1080/09297049608401355
Ebisch S. J., 2010, HUM BRAIN MAPP, V32, P1013, DOI DOI 10.1002/HBM.21085
Fair DA, 2007, NEUROIMAGE, V35, P396, DOI 10.1016/j.neuroimage.2006.11.051
FORMAN SD, 1995, MAGNET RESON MED, V33, P636, DOI 10.1002/mrm.1910330508
Fox MD, 2006, P NATL ACAD SCI USA, V103, P10046, DOI 10.1073/pnas.0604187103
Fox MD, 2007, NAT REV NEUROSCI, V8, P700, DOI 10.1038/nrn2201
Gaffrey MS, 2007, NEUROPSYCHOLOGIA, V45, P1672, DOI 10.1016/j.neuropsychologia.2007.01.008
Goncalves MS, 2001, NEUROIMAGE, V14, P1353, DOI 10.1006/nimg.2001.0954
Gottlieb G, 2002, DEV PSYCHOPATHOL, V14, P421, DOI 10.1017/S0954579402003021
GREENOUGH WT, 1987, CHILD DEV, V58, P539, DOI 10.1111/j.1467-8624.1987.tb01400.x
Groen WB, 2008, NEUROSCI BIOBEHAV R, V32, P1416, DOI 10.1016/j.neubiorev.2008.05.008
Groen WB, 2010, CEREB CORTEX, V20, P1937, DOI 10.1093/cercor/bhp264
Hampson M, 2002, HUM BRAIN MAPP, V15, P247, DOI 10.1002/hbm.10022
Holmes AP, 1997, HUMAN BRAIN FUNCTION, P59
Honey CJ, 2009, P NATL ACAD SCI USA, V106, P2035, DOI 10.1073/pnas.0811168106
Hutsler JJ, 2010, BRAIN RES, V1309, P83, DOI 10.1016/j.brainres.2009.09.120
James GA, 2009, NEUROIMAGE, V45, P778, DOI 10.1016/j.neuroimage.2008.12.049
Jiang TZ, 2004, HUM BRAIN MAPP, V22, P63, DOI 10.1002/hbm.20012
Just MA, 2007, CEREB CORTEX, V17, P951, DOI 10.1093/cercor/bhl006
Just MA, 2004, BRAIN, V127, P1811, DOI 10.1093/brain/awh199
Kamio Y, 2007, J AUTISM DEV DISORD, V37, P1116, DOI 10.1007/s10803-006-0254-3
Kamio Y, 2000, J CHILD PSYCHOL PSYC, V41, P859, DOI 10.1017/S0021963099006137
Kana RK, 2009, SOC NEUROSCI-UK, V4, P135, DOI 10.1080/17470910802198510
Kana RK, 2006, BRAIN, V129, P2484, DOI 10.1093/brain/awl164
Kana RK, 2007, BIOL PSYCHIAT, V62, P198, DOI 10.1016/j.biopsych.2006.08.004
Kandel E.R., 2000, PRINCIPLES NEURAL SC, P1115
Keehn B, 2008, J INT NEUROPSYCH SOC, V14, P990, DOI 10.1017/S1355617708081356
Keller TA, 2007, NEUROREPORT, V18, P23, DOI 10.1097/01.wnr.0000239965.21685.99
Knaus TA, 2008, J INT NEUROPSYCH SOC, V14, P967, DOI 10.1017/S1355617708081216
Koshino H, 2005, NEUROIMAGE, V24, P810, DOI 10.1016/j.neuroimage.2004.09.028
Leveille C, 2010, AUTISM RES, V3, P280, DOI 10.1002/aur.155
Lord C, 2004, DEVELOPMENTAL LANGUAGE DISORDERS: FROM PHENOTYPES TO ETIOLOGIES, P7
LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
Luo LQ, 2005, ANNU REV NEUROSCI, V28, P127, DOI 10.1146/annurev.neuro.28.061604.135632
Mason RA, 2008, NEUROPSYCHOLOGIA, V46, P269, DOI 10.1016/j.neuropsychologia.2007.07.018
McIntosh A. R., 1994, Human Brain Mapping, V2, P2
Mechelli A, 2002, NEUROIMAGE, V17, P1459, DOI 10.1006/nimg.2002.1231
Mizuno A, 2006, BRAIN RES, V1104, P160, DOI 10.1016/j.brainres.2006.05.064
Monk CS, 2009, NEUROIMAGE, V47, P764, DOI 10.1016/j.neuroimage.2009.04.069
Mottron L, 2006, J AUTISM DEV DISORD, V36, P27, DOI 10.1007/s10803-005-0040-7
Muller RA, 2011, CEREB CORTEX, V21, P2233, DOI 10.1093/cercor/bhq296
Mundy P, 2005, HDB AUTISM PERVASIVE, P650
Noonan SK, 2009, BRAIN RES, V1262, P48, DOI 10.1016/j.brainres.2008.12.076
Penny WD, 2004, NEUROIMAGE, V23, pS264, DOI 10.1016/j.neuroimage.2004.07.041
Power J.D., 2011, NEUROIMAGE, V59, P2142, DOI DOI 10.1016/J.NEUR0IMAGE.2011.10.018
ROBB RA, 1989, COMPUT MED IMAG GRAP, V13, P433, DOI 10.1016/0895-6111(89)90285-1
Sahyoun CP, 2009, J AUTISM DEV DISORD, V39, P1014, DOI 10.1007/s10803-009-0712-9
Samson F., 2011, HUM BRAIN MAPP
Schipul Sarah E, 2011, Front Syst Neurosci, V5, P10, DOI 10.3389/fnsys.2011.00010
Shih P, 2010, NEUROPSYCHOLOGIA, V48, P2931, DOI 10.1016/j.neuropsychologia.2010.05.035
Shih P., 2011, BIOL PSYCHIAT
Shukla DK, 2011, J CHILD PSYCHOL PSYC, V52, P286, DOI 10.1111/j.1469-7610.2010.02342.x
Simmons DR, 2009, VISION RES, V49, P2705, DOI 10.1016/j.visres.2009.08.005
Sladky R, 2011, NEUROIMAGE, V58, P588, DOI 10.1016/j.neuroimage.2011.06.078
Soulieres I., 2009, HUM BRAIN MAPP
STEIGER JH, 1990, MULTIVAR BEHAV RES, V25, P173, DOI 10.1207/s15327906mbr2502_4
Tager-Flusberg H., 2005, HDB AUTISM PERVASIVE, P335
Toichi M, 2001, J AUTISM DEV DISORD, V31, P483, DOI 10.1023/A:1012216925216
Toni I, 2002, CEREB CORTEX, V12, P1040, DOI 10.1093/cercor/12.10.1040
Turner Katherine C, 2006, Behav Brain Funct, V2, P34, DOI 10.1186/1744-9081-2-34
Van Dijk KRA, 2010, J NEUROPHYSIOL, V103, P297, DOI 10.1152/jn.00783.2009
Van Dijk KRA, 2012, NEUROIMAGE, V59, P431, DOI 10.1016/j.neuroimage.2011.07.044
Vincent JL, 2006, J NEUROPHYSIOL, V96, P3517, DOI 10.1152/jn.00048.2006
Vlamings PHJM, 2010, BIOL PSYCHIAT, V68, P1107, DOI 10.1016/j.biopsych.2010.06.024
Walenski M, 2008, J AUTISM DEV DISORD, V38, P1395, DOI 10.1007/s10803-007-0513-y
Wechsler D, 1999, WECHSLER ABBREVIATED
Weinstein M, 2011, HUM BRAIN MAPP, V32, P534, DOI 10.1002/hbm.21042
Welchew DE, 2005, BIOL PSYCHIAT, V57, P991, DOI 10.1016/j.biopsych.2005.01.028
Zhang YY, 2001, IEEE T MED IMAGING, V20, P45, DOI 10.1109/42.906424
Zhuang JC, 2008, NEUROIMAGE, V42, P799, DOI 10.1016/j.neuroimage.2008.05.036
Zhuang JC, 2005, NEUROIMAGE, V25, P462, DOI 10.1016/j.neuroimage.2004.11.007
NR 97
TC 6
Z9 7
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 1053-8119
J9 NEUROIMAGE
JI Neuroimage
PD SEP
PY 2012
VL 62
IS 3
BP 1780
EP 1791
DI 10.1016/j.neuroimage.2012.06.008
PG 12
WC Neurosciences; Neuroimaging; Radiology, Nuclear Medicine & Medical
Imaging
SC Neurosciences & Neurology; Radiology, Nuclear Medicine & Medical Imaging
GA 986TR
UT WOS:000307369000045
PM 22699044
ER
PT J
AU Johansson, A
Westberg, L
Sandnabba, K
Jern, P
Salo, B
Santtila, P
AF Johansson, Ada
Westberg, Lars
Sandnabba, Kenneth
Jern, Patrick
Salo, Benny
Santtila, Pekka
TI Associations between oxytocin receptor gene (OXTR) polymorphisms and
self-reported aggressive behavior and anger: Interactions with alcohol
consumption
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Article
DE Aggressive behavior; Alcohol consumption; Anger control;
Gene-environment interaction; Oxytocin receptor gene; rs1488467;
rs4564970; rs1042778; Trait anger
ID IDENTIFICATION TEST AUDIT; AFFILIATIVE BEHAVIOR; EMOTIONAL FACES; SOCIAL
DEFICITS; TRAIT ANGER; HUMANS; AMYGDALA; AUTISM; MICE; QUESTIONNAIRE
AB Oxytocin has been implicated in the regulation of social as well as aggressive behaviors, and in a recent study we found that the effect of alcohol on aggressive behavior was moderated by the individual's genotype on an oxytocin receptor gene (OXTR) polymorphism (Johansson et al., 2012). In this study we wanted to deepen and expand the analysis by exploring associations between three (rs1488467, rs4564970, rs1042778) OXTR polymorphisms and aggressive behavior, trait anger as well as anger control in a population-based sample of Finnish men and women (N = 3577) aged between 18 and 49 years (M = 26.45 years, SD = 5.02). A specific aim was to investigate if the polymorphisms would show interactive effects with alcohol consumption on aggressive behavior and trait anger, as well as to explore whether these polymorphisms affect differences in anger control between self-reported sober and intoxicated states. The results showed no main effects of the polymorphisms, however, three interactions between the polymorphisms and alcohol consumption were found. The effect of alcohol consumption on aggressive behavior was moderated by the genotype of the individual on the rs4564970 polymorphism, in line with previous results (Johansson et al., 2012). For trait anger, both the rs1488467 and the rs4564970 polymorphisms interacted with alcohol consumption. It appears that the region of the OXTR gene including both the rs4564970 and the rs1488467 polymorphisms may be involved in the regulation of the relationship between alcohol and aggressive behavior as well as between alcohol and the propensity to react to situations with elevated levels of anger. (C) 2012 Elsevier Ltd. All rights reserved.
C1 [Johansson, Ada; Sandnabba, Kenneth; Jern, Patrick; Salo, Benny; Santtila, Pekka] Abo Akad Univ, Dept Psychol & Logoped, FIN-20500 Turku, Finland.
[Westberg, Lars] Univ Gothenburg, Sahlgrenska Acad, Dept Pharmacol, Inst Neurosci & Physiol, Gothenburg, Sweden.
RP Johansson, A (reprint author), Abo Akad Univ, Dept Psychol & Logoped, FIN-20500 Turku, Finland.
EM ada.johansson@abo.fi
FU National Graduate School of Psychology, a Center of Excellence Grant
from the Stiftelsen for Abo Akademi Foundation [21/22/05]; Academy of
Finland [136263, 138291]; Swedish Medical Research Council; Marta
Lundqvist Stiftelse; Ake Wibergs Stiftelse; Ahlen-stiftelsen;
Jeanssons-stiftelsen; Soderstrom-Konigska Stiftelsen; Swedish Brain
Foundation
FX This research was financed by the National Graduate School of
Psychology, a Center of Excellence Grant from the Stiftelsen for Abo
Akademi Foundation (Grant No. 21/22/05), Grant Nos. 136263 and 138291
from the Academy of Finland, the Swedish Medical Research Council, Marta
Lundqvist Stiftelse, Ake Wibergs Stiftelse, Ahlen-stiftelsen,
Jeanssons-stiftelsen, Soderstrom-Konigska Stiftelsen, and the Swedish
Brain Foundation.
CR Allen JP, 1997, ALCOHOL CLIN EXP RES, V21, P613, DOI 10.1097/00000374-199706000-00008
Apicella CL, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0011153
Babor TF, 2001, ALCOHOL USE DISORDER, P5
Barrett JC, 2005, BIOINFORMATICS, V21, P263, DOI 10.1093/bioinformatics/bth457
Bartz JA, 2011, TRENDS COGN SCI, V15, P301, DOI 10.1016/j.tics.2011.05.002
Beaver JD, 2008, J NEUROSCI, V28, P2719, DOI 10.1523/JNEUROSCI.0033-08.2008
Belsky J, 2009, PSYCHOL BULL, V135, P885, DOI 10.1037/a0017376
Bernstein DP, 2003, CHILD ABUSE NEGLECT, V27, P169, DOI 10.1016/S0145-2134(02)00541-0
BUSS AH, 1992, J PERS SOC PSYCHOL, V63, P452, DOI 10.1037//0022-3514.63.3.452
Carre J.M., SOC COGN AF IN PRESS
Choleris E, 2007, P NATL ACAD SCI USA, V104, P4670, DOI 10.1073/pnas.0700670104
Coccaro EF, 2011, BIOL PSYCHIAT, V69, P1153, DOI 10.1016/j.biopsych.2011.02.032
Coccaro EF, 2007, BIOL PSYCHIAT, V62, P168, DOI 10.1016/j.biopsych.2006.08.024
De Dreu CKW, 2010, SCIENCE, V328, P1408, DOI 10.1126/science.1189047
DeVries AC, 1997, J NEUROENDOCRINOL, V9, P363, DOI 10.1046/j.1365-2826.1997.t01-1-00589.x
Di Simplicio M, 2009, J PSYCHOPHARMACOL, V23, P241, DOI 10.1177/0269881108095705
Domes G, 2007, BIOL PSYCHIAT, V61, P731, DOI 10.1016/j.biopsych.2006.07.015
Domes G, 2007, BIOL PSYCHIAT, V62, P1187, DOI 10.1016/j.biopsych.2007.03.025
Eckhardt C, 2004, AGGRESS VIOLENT BEH, V9, P17, DOI 10.1016/S1359-1789(02)001167
Eftekhari A, 2004, ADDICT BEHAV, V29, P1001, DOI 10.1016/j.addbeh.2004.02.050
Exum L.M., 2006, J CRIM JUST, V34, P131
FERRIS CF, 1992, ANN NY ACAD SCI, V652, P456, DOI 10.1111/j.1749-6632.1992.tb34382.x
Fetissov SO, 2006, BIOL PSYCHIAT, V60, P799, DOI 10.1016/j.biopsych.2006.03.081
Foran HM, 2008, J FAM VIOLENCE, V23, P141, DOI 10.1007/s10896-007-9136-5
Giancola PR, 2000, EXP CLIN PSYCHOPHARM, V8, P576, DOI 10.1037//1064-1297.8.4.576
GIBBENS GLD, 1976, AM J OBSTET GYNECOL, V126, P243
Harmon AC, 2002, J NEUROENDOCRINOL, V14, P963, DOI 10.1046/j.1365-2826.2002.00863.x
Harris JA, 1997, BEHAV RES THER, V35, P1047, DOI 10.1016/S0005-7967(97)00064-8
HASHIMOTO H, 1985, ENDOCRINOL JAPON, V32, P489
Heinz AJ, 2011, NAT REV NEUROSCI, V12, P400, DOI 10.1038/nrn3042
Helweg-Larsen K., 2002, UNDERSOKELSE MED FOK
Insel TR, 2010, NEURON, V65, P768, DOI 10.1016/j.neuron.2010.03.005
Israel S, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0005535
Jacob S, 2007, NEUROSCI LETT, V417, P6, DOI 10.1016/j.neulet.2007.02.001
Johansson A, 2011, SCAND J PSYCHOL, V52, P382, DOI 10.1111/j.1467-9450.2011.00880.x
Johansson A, 2010, BIOL PSYCHOL, V85, P291, DOI 10.1016/j.biopsycho.2010.07.016
Johansson A, 2012, GENES BRAIN BEHAV, V11, P214, DOI 10.1111/j.1601-183X.2011.00744.x
Jokinen J, 2012, PSYCHONEUROENDOCRINO, V37, P482, DOI 10.1016/j.psyneuen.2011.07.016
Kirsch P, 2005, J NEUROSCI, V25, P11489, DOI 10.1523/JNEUROSCI.3984-05.2005
Knott TK, 2000, ALCOHOL CLIN EXP RES, V24, P1077, DOI 10.1097/00000374-200007000-00020
KRONER DG, 1992, CRIM JUSTICE BEHAV, V19, P397, DOI 10.1177/0093854892019004004
Lee R, 2009, PSYCHONEUROENDOCRINO, V34, P1567, DOI 10.1016/j.psyneuen.2009.06.002
Lerer E, 2008, MOL PSYCHIATR, V13, P980, DOI 10.1038/sj.mp.4002087
Lubin DA, 2003, BEHAV NEUROSCI, V117, P195, DOI 10.1037/0735-7044.117.2.195
Marsh AA, 2010, PSYCHOPHARMACOLOGY, V209, P225, DOI 10.1007/s00213-010-1780-4
Martin RC, 2007, PERS INDIV DIFFER, V43, P2083, DOI 10.1016/j.paid.2007.06.022
McMurray MS, 2008, NEUROTOXICOL TERATOL, V30, P475, DOI 10.1016/j.ntt.2008.07.001
Menella J., 2005, J CLIN ENDOCR METAB, V90, P1979
Menella J., 2006, ALCOHOL, VAlcohol, p[38, 29]
Mustanski B, 2007, HEALTH PSYCHOL, V26, P610, DOI 10.1037/0278-6133.26.5.610
Nelson RJ, 2007, NAT REV NEUROSCI, V8, P536, DOI 10.1038/nrn2174
Neumann I, 1996, J NEUROENDOCRINOL, V8, P227, DOI 10.1046/j.1365-2826.1996.04557.x
Parrott DJ, 2003, ALCOHOL CLIN EXP RES, V27, P937, DOI 10.1097/01.ALC.0000071923.78618.5B
Paulhus D. L., MANUAL SELF IN PRESS
Pedersen CA, 2011, SCHIZOPHR RES, V132, P50, DOI 10.1016/j.schres.2011.07.027
Ragnauth AK, 2005, GENES BRAIN BEHAV, V4, P229, DOI 10.1111/j.1601-183X.2005.00118.x
Rimmele U, 2009, J NEUROSCI, V29, P38, DOI 10.1523/JNEUROSCI.4260-08.2009
Rodrigues SM, 2009, P NATL ACAD SCI USA, V106, P21437, DOI 10.1073/pnas.0909579106
Sala M, 2011, BIOL PSYCHIAT, V69, P875, DOI 10.1016/j.biopsych.2010.12.022
Sariola H., 1994, CHILD ABUSE NEGLECT, V18, P825
SAUNDERS JB, 1993, ADDICTION, V88, P791, DOI 10.1111/j.1360-0443.1993.tb02093.x
Schulze L, 2011, PSYCHONEUROENDOCRINO, V36, P1378, DOI 10.1016/j.psyneuen.2011.03.011
Silva SM, 2002, BRAIN RES, V925, P76, DOI 10.1016/S0006-8993(01)03261-9
Spielberger CD, 1999, STATE TRAIT ANGER EX
Takayanagi Y, 2005, P NATL ACAD SCI USA, V102, P16096, DOI 10.1073/pnas.0505312102
Tauber M., 2011, ORPHANET J RARE DIS, V6, P1
Tikkanen R, 2010, ALCOHOL CLIN EXP RES, V34, P853, DOI 10.1111/j.1530-0277.2010.01157.x
Tikkanen R, 2009, ALCOHOL CLIN EXP RES, V33, P428, DOI 10.1111/j.1530-0277.2008.00853.x
Tost H, 2010, P NATL ACAD SCI USA, V107, P13936, DOI 10.1073/pnas.1003296107
van Ijzendoorn MH, 2012, PSYCHONEUROENDOCRINO, V37, P438, DOI 10.1016/j.psyneuen.2011.07.008
von der Pahlen B, 2008, BIOL PSYCHOL, V78, P269, DOI 10.1016/j.biopsycho.2008.03.013
Winslow JT, 2002, NEUROPEPTIDES, V36, P221, DOI 10.1054/npep.2002.0909
Wu SP, 2005, BIOL PSYCHIAT, V58, P74, DOI 10.1016/j.biopsych.2005.03.013
Yrigollen CM, 2008, BIOL PSYCHIAT, V63, P911, DOI 10.1016/j.biopsych.2007.11.015
ZEICHNER A, 1994, ALCOHOL CLIN EXP RES, V18, P657, DOI 10.1111/j.1530-0277.1994.tb00927.x
NR 75
TC 7
Z9 8
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD SEP
PY 2012
VL 37
IS 9
BP 1546
EP 1556
DI 10.1016/j.psyneuen.2012.02.009
PG 11
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA 991CJ
UT WOS:000307678800018
PM 22421562
ER
PT J
AU Klett, LS
Turan, Y
AF Klett, Lesley S.
Turan, Yasemin
TI Generalized Effects of Social Stories with Task Analysis for Teaching
Menstrual Care to Three Young Girls with Autism
SO SEXUALITY AND DISABILITY
LA English
DT Article
DE Social stories; Autism spectrum disorders; Disability; Sexual education;
Menstrual care; USA
ID PARENTAL PERSPECTIVE; SEXUALITY EDUCATION; SPECTRUM DISORDERS;
ADOLESCENTS; BEHAVIORS; WOMEN
AB Individuals with autism spectrum disorder (ASD) have distinctive needs with respect to sexual development and education. This pilot study evaluates the effectiveness of a parent-implemented Social Story intervention with an embedded visual task analysis to teach menstrual care skills to three young girls with ASD. Skill generalization was evaluated using two different types of pads and a simulated condition (i.e., a pad with red syrup). Social validity of target behaviors, intervention procedures and intervention effects were evaluated. Additionally, qualitative changes in participant behaviors were measured via phone interviews with the participants' mothers (Bruess and Greenberg 1994) 1 year later. Results indicate that participants were more knowledgeable about reproductive development and were able to independently care for their menses regardless of pad type (wings vs. no-wings) and condition (clean vs. dirty). Parents reported high satisfaction with the intervention procedures and outcomes. Implications of the study and future research are discussed.
C1 [Klett, Lesley S.; Turan, Yasemin] San Diego State Univ, San Diego, CA 92182 USA.
RP Turan, Y (reprint author), San Diego State Univ, 5500 Campanile Dr, San Diego, CA 92182 USA.
EM yturan@mail.sdsu.edu
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
Ballan M., 2001, SIECUS REPORT, V29, P14
Bernad-Ripoll S., 2007, FOCUS AUTISM OTHER D, V22, P100, DOI DOI 10.1177/10883576070220020101
Bruess C. E., 1994, SEXUALITY ED THEORY
Caterino L. C., 2008, ED TREATMENT CHILDRE, V31, P381
Cooper J. O., 2007, APPL BEHAV ANAL
EPPS S, 1990, RES DEV DISABIL, V11, P37, DOI 10.1016/0891-4222(90)90004-R
Aunos M, 2002, J APPL RES INTELLECT, V15, P285, DOI 10.1046/j.1468-3148.2002.00135.x
Gray C., 2000, WRITING SOCIAL STORI
Gray C., 2008, SOCIAL STORIES
Gray C., 2008, WHAT ARE SOCIAL STOR
Gray C. A, 2004, JENISON AUTISM J, V15, P2
Haffner D.W., 1995, HLTH NATL COMMISSION
Hellemans H, 2007, J AUTISM DEV DISORD, V37, P260, DOI 10.1007/s10803-006-0159-1
Isler A, 2009, SEX DISABIL, V27, P229, DOI 10.1007/s11195-009-9130-3
Kazdin A. E., 2010, SINGLE CASE RES DESI
Koller R, 2000, SEX DISABIL, V18, P125, DOI 10.1023/A:1005567030442
Kuttler S., 1998, FOCUS AUTISM OTHER D, V13, P176, DOI DOI 10.1177/108835769801300306
Lorimer PA, 2002, J POSIT BEHAV INTERV, V4, P53, DOI 10.1177/109830070200400109
Mansell S., 1996, INT J ADV COUNS, V19, P293
MORSE WH, 1958, J EXP ANAL BEHAV, V1, P103, DOI 10.1901/jeab.1958.1-103
Moudgil A. C., 1970, INDIAN J MENT RETARD, V3, P50
Myles B. S., 1999, FOCUS AUTISM OTHER D, V14, P82, DOI 10.1177/108835769901400203
Nichols S, 2005, J EVIDENCE BASED PRA, V6, P90
Quilty KM, 2007, REM SPEC EDUC, V28, P182
Realmuto GM, 1999, J AUTISM DEV DISORD, V29, P121, DOI 10.1023/A:1023088526314
RICHMAN GS, 1986, APPL RES MENT RETARD, V7, P21, DOI 10.1016/0270-3092(86)90015-9
RICHMAN GS, 1984, J APPL BEHAV ANAL, V17, P441, DOI 10.1901/jaba.1984.17-441
RUBLE LA, 1993, ARCH SEX BEHAV, V22, P229, DOI 10.1007/BF01541768
Scattone D, 2002, J AUTISM DEV DISORD, V32, P535, DOI 10.1023/A:1021250813367
Schopler E., 1997, HDB AUTISM PERVASIVE, P765
Snell M. E., 2010, INSTRUCTION STUDENTS
Soenksen D., 2006, FOCUS AUTISM OTHER D, V21, P36, DOI DOI 10.1177/10883576060210010501
Sparrow S, 1984, VINELAND ADAPTIVE BE
Stokes MA, 2005, AUTISM, V9, P266, DOI 10.1177/1362361305053258
Tarnai B, 2008, SEX DISABIL, V26, P29, DOI 10.1007/s11195-007-9067-3
Test D. W., 2010, FOCUS AUTISM OTHER D, V26, P49
Toplis R., 2006, ED PSYCHOL PRACTICE, V22, P53, DOI DOI 10.1080/02667360500512437
Travers J, 2010, EDUC TRAIN AUTISM DE, V45, P284
Wheeler A.J., 1997, MURDOCH CTR PROGRAM, VII
Wilkenfeld BF, 2011, SEX DISABIL, V29, P351, DOI 10.1007/s11195-011-9211-y
Wrobel M., 2003, TAKING CARE MYSELF H
NR 42
TC 4
Z9 4
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0146-1044
J9 SEX DISABIL
JI Sex. Disabil.
PD SEP
PY 2012
VL 30
IS 3
BP 319
EP 336
DI 10.1007/s11195-011-9244-2
PG 18
WC Rehabilitation
SC Rehabilitation
GA 989FG
UT WOS:000307545100006
ER
PT J
AU Bracher, M
Thackray, L
AF Bracher, Mike
Thackray, Liz
TI Understanding Autism: Patients, Doctors, and the History of a Disorder
SO SOCIOLOGY OF HEALTH & ILLNESS
LA English
DT Book Review
C1 [Bracher, Mike] Univ Southampton, Southampton SO9 5NH, Hants, England.
[Thackray, Liz] Univ Sussex, Brighton BN1 9RH, E Sussex, England.
RP Bracher, M (reprint author), Univ Southampton, Southampton SO9 5NH, Hants, England.
CR Silverman C, 2012, UNDERSTANDING AUTISM: PARENTS, DOCTORS, AND THE HISTORY OF A DISORDER, P1
NR 1
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0141-9889
EI 1467-9566
J9 SOCIOL HEALTH ILL
JI Sociol. Health Ill.
PD SEP
PY 2012
VL 34
IS 7
BP 1119
EP 1122
PG 4
WC Public, Environmental & Occupational Health; Social Sciences,
Biomedical; Sociology
SC Public, Environmental & Occupational Health; Biomedical Social Sciences;
Sociology
GA 984WN
UT WOS:000307223600015
ER
PT J
AU Bracher, M
Thackray, L
AF Bracher, Mike
Thackray, Liz
TI The Myth of Autism
SO SOCIOLOGY OF HEALTH & ILLNESS
LA English
DT Book Review
C1 [Bracher, Mike] Univ Southampton, Southampton SO9 5NH, Hants, England.
[Thackray, Liz] Univ Sussex, Brighton BN1 9RH, E Sussex, England.
RP Bracher, M (reprint author), Univ Southampton, Southampton SO9 5NH, Hants, England.
CR McCabe N., 2011, MYTH AUTISM
NR 1
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0141-9889
J9 SOCIOL HEALTH ILL
JI Sociol. Health Ill.
PD SEP
PY 2012
VL 34
IS 7
BP 1119
EP 1122
PG 4
WC Public, Environmental & Occupational Health; Social Sciences,
Biomedical; Sociology
SC Public, Environmental & Occupational Health; Biomedical Social Sciences;
Sociology
GA 984WN
UT WOS:000307223600016
ER
PT J
AU Bracher, M
Thackray, L
AF Bracher, Mike
Thackray, Liz
TI A History of Autism: Conversations with the Pioneers
SO SOCIOLOGY OF HEALTH & ILLNESS
LA English
DT Book Review
C1 [Bracher, Mike] Univ Southampton, Southampton SO9 5NH, Hants, England.
[Thackray, Liz] Univ Sussex, Brighton BN1 9RH, E Sussex, England.
RP Bracher, M (reprint author), Univ Southampton, Southampton SO9 5NH, Hants, England.
CR Feinstein Adam, 2010, HIST AUTISM CONVERSA
Silverman C, 2008, BIOSOCIETIES, V3, P325, DOI 10.1017/S1745855208006236
NR 2
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0141-9889
J9 SOCIOL HEALTH ILL
JI Sociol. Health Ill.
PD SEP
PY 2012
VL 34
IS 7
BP 1119
EP 1122
DI 10.1111/j.1467-9566.2012.01507.x
PG 4
WC Public, Environmental & Occupational Health; Social Sciences,
Biomedical; Sociology
SC Public, Environmental & Occupational Health; Biomedical Social Sciences;
Sociology
GA 984WN
UT WOS:000307223600012
ER
PT J
AU Steinhausen, HC
AF Steinhausen, Hans-Christoph
TI Autism spectrum disorders
SO ACTA PSYCHIATRICA SCANDINAVICA
LA English
DT Book Review
C1 [Steinhausen, Hans-Christoph] Aarhus Univ Hosp, Aalborg Psychiat Hosp, Chair Child & Adolescent Psychiat, Aalborg, Denmark.
RP Steinhausen, HC (reprint author), Aarhus Univ Hosp, Aalborg Psychiat Hosp, Chair Child & Adolescent Psychiat, Aalborg, Denmark.
EM hces@rn.dk
CR Amaral D., 2011, AUTISM SPECTRUM DISO
NR 1
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0001-690X
J9 ACTA PSYCHIAT SCAND
JI Acta Psychiatr. Scand.
PD SEP
PY 2012
VL 126
IS 3
BP 229
EP 229
DI 10.1111/j.1600-0447.2012.01881.x
PG 1
WC Psychiatry
SC Psychiatry
GA 986WE
UT WOS:000307375500008
ER
PT J
AU Schwartzberg, ET
Silverman, MJ
AF Schwartzberg, Edward Todd
Silverman, Michael J.
TI Effects of pitch, rhythm, and accompaniment on short- and long-term
visual recall in children with autism spectrum disorders
SO ARTS IN PSYCHOTHERAPY
LA English
DT Article
DE ASD; Autism; Memory; Music; Music therapy; Paired-associate; Recall;
Visual
ID RECOGNITION MEMORY; MUSIC; INFORMATION; STUDENTS; TEXT; PERFORMANCE;
RETENTION; MELODIES
AB The purpose of the study was to examine paired associate effects of speech, rhythm, pitch, and accompaniment on short- and long-term recall of visual information in children with ASD and in neuro-typical children. The principle investigator (PI) collected phase one data (n = 42 children with ASD) during three separate one-week summer camps and phase two data (n = 14 neuro-typical children) during an academic year at a local religious institution. Participants received the seven-item visual stimuli paired with one of four music conditions (speech, rhythm, pitch, and accompaniment). The PI tested participants in both short- and long-term conditions. Results for phase one were statistically significant for term, with more accurate recall during the short-term phase. Although there were no significant between-condition differences, short- and long-term recall were most accurate during the accompaniment condition and least accurate in the speech condition. Regardless of condition, participants had better recall during sequential positions of primacy and recency. Neuro-typical participants had higher mean recall across all four conditions and two terms than participants with ASD. When delivering visual information to children with ASD, clinicians might consider pairing it with music to facilitate recall. Implications for clinical practice, limitations, and suggestions for future research are provided. (C) 2012 Elsevier Inc. All rights reserved.
C1 [Schwartzberg, Edward Todd] Univ Minnesota, Sch Mus, Minneapolis, MN 55455 USA.
RP Schwartzberg, ET (reprint author), Univ Minnesota, Sch Mus, 100 Ferguson Hall,2106 4th St S, Minneapolis, MN 55455 USA.
EM schwa155@umn.edu
CR AMELI R, 1988, J AUTISM DEV DISORD, V18, P601, DOI 10.1007/BF02211878
BARTH C, 1995, DEV NEUROPSYCHOL, V11, P53
Bauman ML, 2005, INT J DEV NEUROSCI, V23, P183, DOI 10.1016/j.ijdevneu.2004.09.006
Bondy A. S., 1994, FOCUS AUTISTIC BEHAV, V9, P1, DOI DOI 10.1177/108835769400900301
Brown MW, 2001, NAT REV NEUROSCI, V2, P51, DOI 10.1038/35049064
Brownell MD, 2002, J MUSIC THER, V39, P117
Choi BC, 2008, J MUSIC THER, V45, P93
Claussen D. W., 1997, CANADIAN J MUSIC THE, V5, P55
Committee on Educational Interventions for Children with Autism, 2001, ED CHILDR AUT
CRAIK FIM, 1973, J VERB LEARN VERB BE, V12, P599, DOI 10.1016/S0022-5371(73)80039-8
Denis M., 1984, TEXT, V4, P381, DOI 10.1515/text.1.1984.4.4.381
DiCicco-Bloom E, 2006, J NEUROSCI, V26, P6897, DOI 10.1523/JNEUROSCI.1712-06.2006
FREDRICKSON BL, 1993, J PERS SOC PSYCHOL, V65, P45, DOI 10.1037//0022-3514.65.1.45
GFELLER KE, 1983, J MUSIC THER, V20, P179
Goldstein H., 1999, 1 WORKSH COMM ED INT
Grandin T., 1995, THINKING PICTURES OT
Hebert S, 1997, MEM COGNITION, V25, P518, DOI 10.3758/BF03201127
Hodgdon L. A., 1995, VISUAL STRATEGIES IM
JELLISON JA, 1976, J MUSIC THER, V13, P114
Kennedy R., 2001, MUSIC THERAPY PERSPE, V19, P128
Kilgour AR, 2000, MEM COGNITION, V28, P700, DOI 10.3758/BF03198404
Krout R. E., 2006, ARTS PSYCHOTHERAPY, V34, P36
LEVIN JR, 1980, ECTJ-EDUC COMMUN TEC, V28, P177
MARSCHARK M, 1987, PSYCHOL BULL, V102, P28, DOI 10.1037/0033-2909.102.1.28
Mayer-Johnson L. L C., 2008, BOARDMAKER VERSION 6
MILLER GA, 1956, PSYCHOL REV, V63, P81, DOI 10.1037/0033-295X.101.2.343
Moore KS, 2008, J MUSIC THER, V45, P307
National Autism Center, 2009, NAT STAND PROJ FIND
PAIVIO A, 1991, CAN J PSYCHOL, V45, P255, DOI 10.1037/h0084295
PRIOR MR, 1976, J AUTISM CHILD SCHIZ, V6, P121, DOI 10.1007/BF01538055
Rainey DW, 2002, MUSIC PERCEPT, V20, P173, DOI 10.1525/mp.2002.20.2.173
Schunk D. H., 2004, LEARNING THEORIES ED
Silverman MJ, 2007, J MUSIC THER, V44, P415
SPSS Inc, 2009, SPSS BAS 17 0 WIND U
Steele KM, 1997, PERCEPT MOTOR SKILL, V84, P1179
WALLACE WT, 1994, J EXP PSYCHOL LEARN, V20, P1471, DOI 10.1037//0278-7393.20.6.1471
Whipple J, 2004, J MUSIC THER, V41, P90
Williams D., 1992, NOBODY NOWHERE EXTRA
Williams DL, 2006, NEUROPSYCHOLOGY, V20, P21, DOI 10.1037/0894-4105.20.1.21
WOLFE DE, 1993, J MUSIC THER, V30, P100
NR 40
TC 2
Z9 2
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0197-4556
J9 ART PSYCHOTHER
JI Arts Psychother.
PD SEP
PY 2012
VL 39
IS 4
BP 314
EP 320
DI 10.1016/j.aip.2012.05.001
PG 7
WC Psychology, Clinical; Rehabilitation
SC Psychology; Rehabilitation
GA 984QB
UT WOS:000307205000012
ER
PT J
AU Harrison, A
Tchanturia, K
Naumann, U
Treasure, J
AF Harrison, Amy
Tchanturia, Kate
Naumann, Ulrike
Treasure, Janet
TI Social emotional functioning and cognitive styles in eating disorders
SO BRITISH JOURNAL OF CLINICAL PSYCHOLOGY
LA English
DT Article
ID AUTISM SPECTRUM DISORDERS; WEAK CENTRAL COHERENCE; ANOREXIA-NERVOSA;
PROCESSING STREAM; ASPERGER-SYNDROME; REVISED VERSION; RECOVERY;
VALIDATION; ATTENTION; INTERVIEW
AB Objectives. Contemporary models of eating disorders (EDs) argue that both cognitive style (weak coherence and poor set shifting) and social emotional difficulties are involved in the maintenance of EDs. This study aimed to explore the factor structure of cognitive and social emotional functioning and to investigate whether a particular cognitive or social emotional profile was associated with a more severe and chronic form of illness. Design. A cross-sectional design was used to investigate cognitive and social emotional functioning in people with EDs compared to healthy controls (HCs) and those recovered from an ED. Methods. Two hundred twenty-five participants were assessed (100 with an ED, 35 recovered from an ED, and 90 HCs) using a battery of set shifting, coherence, and social emotional measures. Results. There were no significant correlations between the cognitive or social emotional variables. A principal components analysis (PCA) identified three components: a fragmented perseverative cognitive style, for which the ED group scored highly, a global flexible cognitive style, for which HCs scored highly, and a social emotional difficulties profile, for which those with EDs scored highly. Individuals in recovery from an ED did not differ from the acute group, suggesting this cognitive and social emotional profile may be a trait associated with EDs. ED participants scoring highest for the fragmented perseverative cognitive style and social emotional difficulties had a more severe and chronic form of illness. Conclusions. The findings provide empirical support for Schmidt and Treasure's (2006) maintenance model of EDs and suggest both cognition and emotional functioning should be considered in treatment.
C1 [Harrison, Amy; Tchanturia, Kate; Treasure, Janet] Kings Coll London, Inst Psychiat, Sect Eating Disorders, London SE1 9RT, England.
[Naumann, Ulrike] Kings Coll London, Inst Psychiat, Dept Biostat & Comp, London SE1 9RT, England.
RP Harrison, A (reprint author), Kings Coll London, Guys Hosp, Eating Disorders Res Unit, Dept Psychol Med,Inst Psychiat, 5th Floor, London SE1 9RT, England.
EM amy.harrison@kcl.ac.uk
RI Naumann, Ulrike/C-1262-2011
CR American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4
Ashwin C, 2006, PSYCHOL MED, V36, P835, DOI 10.1017/S0033291706007203
Baron-Cohen S, 2001, J CHILD PSYCHOL PSYC, V42, P241, DOI 10.1017/S0021963001006643
Booth R., 2006, THESIS KINGS COLL LO
Burgess PW, 1997, HAYLING BRIXTON TEST
Burnette CP, 2005, J AUTISM DEV DISORD, V35, P63, DOI 10.1007/s10803-004-1035-5
CATTELL RB, 1966, MULTIVAR BEHAV RES, V1, P245, DOI 10.1207/s15327906mbr0102_10
Chow S, 2005, EUL DIAGR WORKSH PAR
Cohen J., 1988, STAT POWER ANAL BEHA, V2nd
COHEN J, 1992, PSYCHOL BULL, V112, P155, DOI 10.1037/0033-2909.112.1.155
Compton RJ, 2004, COGNITIVE THER RES, V28, P733, DOI 10.1007/s10608-004-0663-6
Constantino JN, 2004, J CHILD PSYCHOL PSYC, V45, P719, DOI 10.1111/j.1469-7610.2004.00266.x
Constantino JN, 2002, SOCIAL RESPONSIVENES
Couturier J, 2006, INT J EAT DISORDER, V39, P550, DOI 10.1002/eat.20309
Dolhanty J, 2009, CLIN PSYCHOL PSYCHOT, V16, P366, DOI 10.1002/cpp.624
Dworzynski K, 2009, J AUTISM DEV DISORD, V39, P1197, DOI 10.1007/s10803-009-0736-1
Fairburn C. G., 2008, COGNITIVE BEHAV THER
FAIRBURN CG, 1994, INT J EAT DISORDER, V16, P363
Field A., 2005, DISCOVERING STAT USI, V2nd
First M. B., 1996, STRUCTURED CLIN INTE
Foa EB, 2002, PSYCHOL ASSESSMENT, V14, P485, DOI 10.1037//1040-3590.14.4.485
Forster KI, 2003, BEHAV RES METH INS C, V35, P116, DOI 10.3758/BF03195503
Geurts HM, 2009, TRENDS COGN SCI, V13, P74, DOI 10.1016/j.tics.2008.11.006
Gillberg IC, 2010, J CLIN EXP NEUROPSYC, V32, P358, DOI 10.1080/13803390903066857
Goodman R, 2000, J CHILD PSYCHOL PSYC, V41, P645, DOI 10.1111/j.1469-7610.2000.tb02345.x
Greve KW, 2005, ARCH CLIN NEUROPSYCH, V20, P355, DOI 10.1016/j.acn.2004.09.004
Happe FGE, 2008, Q J EXP PSYCHOL, V61, P50, DOI 10.1080/17470210701508731
Harrison A, 2010, PSYCHOL MED, V40, P1887, DOI 10.1017/S0033291710000036
Harrison A., 2011, WORLD J BIOL PSYCHIA, DOI [10.3109/15622975.2010.551666, DOI 10.3109/15622975.2010.551666]
Harrison A, 2010, BIOL PSYCHIAT, V68, P755, DOI 10.1016/j.biopsych.2010.04.037
Heaton RK, 1993, WISCONSIN CARD SORTI
JONES BP, 1991, J CLIN EXP NEUROPSYC, V13, P711, DOI 10.1080/01688639108401085
KAISER HF, 1974, PSYCHOMETRIKA, V39, P31, DOI 10.1007/BF02291575
Kordy H, 2002, J CLIN PSYCHOL, V58, P833, DOI 10.1002/jclp.2013
Leerkes EM, 2008, MERRILL PALMER QUART, V54, P102, DOI 10.1353/mpq.2008.0009
Lezak M. D., 1995, NEUROPSYCHOLOGICAL A, V3rd
Lopez C, 2008, PSYCHOL MED, V38, P1393, DOI 10.1017/S0033291708003486
Lopez C, 2009, J CLIN EXP NEUROPSYC, V31, P117, DOI 10.1080/13803390802036092
LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
Lovibond SH, 1995, MANUAL DEPRESSION AN
McNair DM, 1971, MANUAL PROFILE MOOD
Nelson HE, 1991, NATL ADULT READING T, V2nd
Nunn K, 2008, EUR EAT DISORD REV, V16, P355, DOI 10.1002/erv.890
Nunnally J. C., 1978, PSYCHOMETRIC THEORY
Ochsner KN, 2008, BIOL PSYCHIAT, V64, P48, DOI 10.1016/j.biopsych.2008.04.024
Oldershaw A, 2011, NEUROSCI BIOBEHAV R, V35, P970, DOI 10.1016/j.neubiorev.2010.11.001
Osterrieth P, 1944, ARCH PSYCHOL, V30, P206
Power M., 2010, EMOTION FOCUSED COGN
Roberts ME, 2010, J PSYCHIATR RES, V44, P964, DOI 10.1016/j.jpsychires.2010.03.001
Roberts ME, 2007, PSYCHOL MED, V37, P1075, DOI 10.1017/S0033291707009877
Rosenthal R, 1991, METAANALYTIC PROCEDU
Schmidt U, 2006, BRIT J CLIN PSYCHOL, V45, P343, DOI 10.1348/014466505X53902
SNODGRASS JG, 1987, BEHAV RES METH INSTR, V19, P270, DOI 10.3758/BF03203798
South M., 2007, AUTISM, V11, P441
Tchanturia K., 2010, COGNITIVE REMEDIATIO
Tchanturia K, 2004, J PSYCHIAT RES, V38, P545, DOI 10.1016/j.jphyschires.2004.03.001
Treasure J, 2010, LANCET, V375, P583, DOI 10.1016/S0140-6736(09)61748-7
von Holle A, 2008, AUST NZ J PSYCHIAT, V42, P108, DOI 10.1080/00048670701787610
Witkin H. A., 2002, GROUP EMBEDDED FIGUR
NR 59
TC 16
Z9 16
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0144-6657
J9 BRIT J CLIN PSYCHOL
JI Br. J. Clin. Psychol.
PD SEP
PY 2012
VL 51
BP 261
EP 279
DI 10.1111/j.2044-8260.2011.02026.x
PN 3
PG 19
WC Psychology, Clinical
SC Psychology
GA 973ZM
UT WOS:000306399400002
PM 22803934
ER
PT J
AU Fletcher-Watson, S
Leekam, SR
Connolly, B
Collis, JM
Findlay, JM
McConachie, H
Rodgers, J
AF Fletcher-Watson, Sue
Leekam, Susan R.
Connolly, Brenda
Collis, Jess M.
Findlay, John M.
McConachie, Helen
Rodgers, Jacqui
TI Attenuation of change blindness in children with autism spectrum
disorders
SO BRITISH JOURNAL OF DEVELOPMENTAL PSYCHOLOGY
LA English
DT Article
ID WILLIAMS-SYNDROME; NATURALISTIC SCENES; EYE-MOVEMENTS; ATTENTION;
INDIVIDUALS; INFORMATION; PERCEPTION; COMPETENCE; COHERENCE; COGNITION
AB Change blindness refers to the difficulty most people find in detecting a difference between two pictures when these are presented successively, with a brief interruption between. Attention at the site of the change is required for detection. A number of studies have investigated change blindness in adults and children with autism spectrum disorders (ASD). Some have produced evidence that people with ASD find changes to social stimuli harder to detect and changes to non-social stimuli easier to detect, relative to comparison participants. However, other studies have produced entirely contradictory findings. There is a need for consistency in methodology to aid understanding of change blindness and attentional processes in ASD. Here, we replicate a change blindness study previously carried out with typically developing (TD) children and adults and with adults with ASD. Results reveal attenuated change blindness for non-social stimuli in children with ASD relative to TD norms. Our results are interpreted, alongside others' findings, as potentially indicative of a complex relationship between different influences on attention over time.
C1 [Fletcher-Watson, Sue] Univ Edinburgh, Moray House Sch Educ, Edinburgh EH8 8AQ, Midlothian, Scotland.
[Leekam, Susan R.; Collis, Jess M.; Findlay, John M.] Univ Durham, Dept Psychol, Durham DH1 3HP, England.
[Fletcher-Watson, Sue; Connolly, Brenda; McConachie, Helen] Newcastle Univ, Inst Hlth & Soc, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England.
[Rodgers, Jacqui] Newcastle Univ, Inst Neurosci, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England.
RP Fletcher-Watson, S (reprint author), Univ Edinburgh, Moray House Sch Educ, Holyrood Rd, Edinburgh EH8 8AQ, Midlothian, Scotland.
EM sue.fletcher-watson@ed.ac.uk
CR Ames C, 2010, DEV REV, V30, P52, DOI 10.1016/j.dr.2009.12.003
Ashwin C., 2010, INT M AUT RES CHIC I
Burack JA, 2009, J AUTISM DEV DISORD, V39, P471, DOI 10.1007/s10803-008-0647-6
Fletcher-Watson S, 2008, J AUTISM DEV DISORD, V38, P1785, DOI 10.1007/s10803-008-0548-8
Fletcher-Watson S, 2009, DEVELOPMENTAL SCI, V12, P438, DOI 10.1111/j.1467-7687.2008.00784.x
Fletcher-Watson S, 2009, NEUROPSYCHOLOGIA, V47, P248, DOI 10.1016/j.neuropsychologia.2008.07.016
Fletcher-Watson S, 2006, BRIT J PSYCHOL, V97, P537, DOI 10.1348/000712606X114057
Freeth M, 2010, J AUTISM DEV DISORD, V40, P534, DOI 10.1007/s10803-009-0893-2
FRITH U, 1994, COGNITION, V50, P115, DOI 10.1016/0010-0277(94)90024-8
Happe F, 2006, J AUTISM DEV DISORD, V36, P5, DOI 10.1007/s10803-005-0039-0
Happe FGE, 1996, J CHILD PSYCHOL PSYC, V37, P873, DOI 10.1111/j.1469-7610.1996.tb01483.x
Jones BT, 2003, ADDICTION, V98, P235, DOI 10.1046/j.1360-0443.2003.00270.x
Kaufman A. S., 1983, K ABC KAUFMAN ASSESS
Kikuchi Y, 2009, CHILD DEV, V80, P1421, DOI 10.1111/j.1467-8624.2009.01342.x
Klin A, 2003, PHILOS T ROY SOC B, V358, P345, DOI 10.1098/rstb.2002.1202
Klin A, 2002, ARCH GEN PSYCHIAT, V59, P809, DOI 10.1001/archpsyc.59.9.809
Loth E, 2008, AUTISM RES, V1, P179, DOI 10.1002/aur.19
Milne E., 2008, J CHILD PSYCHOL PSYC, V50, P300, DOI [10.1111/j.1469-7610.2008.01957.x, DOI 10.1111/J.1469-7610.2008.01957.X]
Mottron L, 2006, J AUTISM DEV DISORD, V36, P27, DOI 10.1007/s10803-005-0040-7
Mundy P, 2007, CURR DIR PSYCHOL SCI, V16, P269, DOI 10.1111/j.1467-8721.2007.00518.x
New JJ, 2010, NEUROPSYCHOLOGIA, V48, P51, DOI 10.1016/j.neuropsychologia.2009.08.008
Norbury CF, 2009, J CHILD PSYCHOL PSYC, V50, P834, DOI 10.1111/j.1469-7610.2009.02073.x
Rensink RA, 1997, PSYCHOL SCI, V8, P368, DOI 10.1111/j.1467-9280.1997.tb00427.x
Riby D, 2009, J INTELL DISABIL RES, V53, P169, DOI 10.1111/j.1365-2788.2008.01142.x
Riby DM, 2008, NEUROPSYCHOLOGIA, V46, P2855, DOI 10.1016/j.neuropsychologia.2008.05.003
Riby DM, 2009, J AUTISM DEV DISORD, V39, P421, DOI 10.1007/s10803-008-0641-z
Ropar D, 1999, J CHILD PSYCHOL PSYC, V40, P1283, DOI 10.1017/S0021963099004667
Rutkowski JS, 2003, J VISION, V3, P95, DOI 10.1167/3.1.10
Schultz RT, 2005, INT J DEV NEUROSCI, V23, P125, DOI 10.1016/j.ijdevneu.2004.12.012
Shore DI, 2006, DEVELOPMENTAL SCI, V9, P490, DOI 10.1111/j.1467-7687.2006.00516.x
Simons DJ, 1997, TRENDS COGN SCI, V1, P261, DOI 10.1016/S1364-6613(97)01080-2
Snowden RJ, 2004, SCHIZOPHR RES, V67, P256
Speer LL, 2007, AUTISM, V11, P265, DOI 10.1177/1362361307076925
Spence SH, 1998, BEHAV RES THER, V36, P545, DOI 10.1016/S0005-7967(98)00034-5
Walter E, 2009, J AUTISM DEV DISORD, V39, P339, DOI 10.1007/s10803-008-0630-2
Wechsler D, 1991, WECHSLER INTELLIGENC, V3rd
Werner S, 2000, VIS COGN, V7, P163
WHO, 1993, ICD 10 CLASS MENT BE
Witkin HA, 1971, MANUAL EMBEDDED FIGU
NR 39
TC 4
Z9 4
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0261-510X
J9 BRIT J DEV PSYCHOL
JI Br. J. Dev. Psychol.
PD SEP
PY 2012
VL 30
IS 3
BP 446
EP 458
DI 10.1111/j.2044-835X.2011.02054.x
PG 13
WC Psychology, Developmental
SC Psychology
GA 986ZD
UT WOS:000307385300006
PM 22882373
ER
PT J
AU Fu, C
Cawthon, B
Clinkscales, W
Bruce, A
Winzenburger, P
Ess, KC
AF Fu, Cary
Cawthon, Bryan
Clinkscales, William
Bruce, Adrienne
Winzenburger, Peggy
Ess, Kevin C.
TI GABAergic Interneuron Development and Function Is Modulated by the Tsc1
Gene
SO CEREBRAL CORTEX
LA English
DT Article
DE epilepsy; GABA; hamartin; mTOR; mTORC1
ID TUBEROUS SCLEROSIS COMPLEX; GAMMA-AMINOBUTYRIC-ACID; CAUDAL GANGLIONIC
EMINENCE; SUBSTANTIA-NIGRA; CORTICAL INTERNEURONS; KNOCKOUT MICE; MOUSE
MODEL; MTOR; EPILEPSY; SEIZURES
AB Tuberous sclerosis complex (TSC) is a genetic disease with severe neurologic and psychiatric manifestations including epilepsy, developmental delay, and autism. Despite much progress in defining abnormal signaling pathways including the contribution of increased mTORC1 signaling, specific abnormalities that underlie the severe neurologic features in TSC remain poorly understood. We hypothesized that epilepsy and autism in TSC result from abnormalities of gamma-aminobutyric acidergic (GABAergic) interneurons. To test this hypothesis, we generated conditional knockout mice with selective deletion of the Tsc1 gene in GABAergic interneuron progenitor cells. These interneuron-specific Tsc1 conditional knockout (CKO) mice have impaired growth and decreased survival. Cortical and hippocampal GABAergic interneurons of CKO mice are enlarged and show increased mTORC1 signaling. Total numbers of GABAergic cells are reduced in the cortex with differential reduction of specific GABAergic subtypes. Ectopic clusters of cells with increased mTORC1 signaling are also seen suggesting impaired interneuron migration. The functional consequences of these cellular changes are evident in the decreased seizure threshold on exposure to the proconvulsant flurothyl. These findings support an important role for the Tsc1 gene during GABAergic interneuron development, function, and possibly migration.
C1 [Fu, Cary; Cawthon, Bryan; Clinkscales, William; Bruce, Adrienne; Winzenburger, Peggy; Ess, Kevin C.] Vanderbilt Univ, Dept Neurol, Nashville, TN 37232 USA.
[Ess, Kevin C.] Vanderbilt Univ, Vanderbilt Kennedy Ctr Res Human Dev, Nashville, TN 37232 USA.
RP Ess, KC (reprint author), Vanderbilt Univ, Dept Neurol, 465 21st Ave S,6158 MRBIII, Nashville, TN 37232 USA.
EM kevin.ess@vanderbilt.edu
FU American Epilepsy Society/Milken Family Early Career Award; National
Institute of Neurological Disorders and Stroke; National Institutes of
Health (NIH) [5K08NS050484]; Tuberous Sclerosis Alliance Postdoctoral
Fellowship award; National Institute of Mental Health, NIH [T32
MH065215-07]; Vanderbilt Ingram Cancer Center [P30 CA68485]; Vanderbilt
Digestive Disease Research Center [DK058404]
FX American Epilepsy Society/Milken Family Early Career Award; National
Institute of Neurological Disorders and Stroke; National Institutes of
Health (NIH) (5K08NS050484) (to K.C.E.). Additional support from a
Tuberous Sclerosis Alliance Postdoctoral Fellowship award as well as
National Institute of Mental Health, NIH (T32 MH065215-07) (to C.F.).We
thank Dr Kenneth Campbell for his generous gift of Dlx5/6-Cre-IRES-EGFP
transgenic mice. Flow cytometry experiments were performed in the VMC
Flow Cytometry Shared Resource. The VMC Flow Cytometry Shared Resource
is supported by the Vanderbilt Ingram Cancer Center (P30 CA68485) and
the Vanderbilt Digestive Disease Research Center (DK058404). Conflict of
Interest : None declared.
CR Avellino AM, 1997, J NEUROSURG, V87, P391, DOI 10.3171/jns.1997.87.3.0391
Baudoin JP, 2008, DEV NEUROSCI-BASEL, V30, P132, DOI 10.1159/000109858
Bellion A, 2005, J NEUROSCI, V25, P5691, DOI 10.1523/JNEUROSCI.1030-05.2005
Chandra PS, 2006, EPILEPSIA, V47, P1543, DOI 10.1111/j.1528-1167.2006.00627.x
Crino PB, 2004, J CHILD NEUROL, V19, P716
Crino PB, 2006, NEW ENGL J MED, V355, P1345, DOI 10.1056/NEJMra055323
Curatolo P, 2001, BRAIN DEV-JPN, V23, P649, DOI 10.1016/S0387-7604(01)00290-X
Curatolo P, 2008, LANCET, V372, P657, DOI 10.1016/S0140-6736(08)61279-9
Fingar DC, 2004, MOL CELL BIOL, V24, P200, DOI 10.1128/MCB.24.1.200-216.2004
GALE K, 1993, BRAIN RES, V603, P279, DOI 10.1016/0006-8993(93)91248-Q
GALE K, 1992, J CLIN NEUROPHYSIOL, V9, P264, DOI 10.1097/00004691-199204010-00007
GALE K, 1985, FED PROC, V44, P2414
Gelman DM, 2009, J NEUROSCI, V29, P9380, DOI 10.1523/JNEUROSCI.0604-09.2009
Gomez M. R., 1999, TUBEROUS SCLEROSIS C
Goodman M, 1997, J CHILD NEUROL, V12, P85
Gutierrez GC, 1998, J AUTISM DEV DISORD, V28, P97, DOI 10.1023/A:1026032413811
Hashimoto I, 2008, EUR J CANCER, V44, P1022, DOI 10.1016/j.ejca.2008.02.043
Hay N, 2004, GENE DEV, V18, P1926, DOI 10.1101/gad.1212704
Holmes GL, 2007, EPILEPSIA, V48, P617, DOI 10.1111/j.1528-1167.2007.01035.x
Huang JX, 2009, BIOCHEM SOC T, V37, P217, DOI 10.1042/BST0370217
Huang JX, 2008, MOL CELL BIOL, V28, P4104, DOI 10.1128/MCB.00289-08
HUNT A, 1987, DEV MED CHILD NEUROL, V29, P190
IADAROLA MJ, 1982, SCIENCE, V218, P1237, DOI 10.1126/science.7146907
Inoki K, 2003, GENE DEV, V17, P1829, DOI 10.1101/gad.1110003
Kagawa K, 2005, J CHILD NEUROL, V20, P429
Kappeler C, 2006, HUM MOL GENET, V15, P1387, DOI 10.1093/hmg/ddl062
Kassiri J, 2011, PEDIATR NEUROL, V44, P328, DOI 10.1016/j.pediatrneurol.2011.01.001
Kasugai M, 2007, BIOCHEM BIOPH RES CO, V357, P1078, DOI 10.1016/j.bbrc.2007.04.067
Kim DH, 2002, CELL, V110, P163, DOI 10.1016/S0092-8674(02)00808-5
Kohwi M, 2007, J NEUROSCI, V27, P6878, DOI 10.1523/JNEUROSCI.0254-07.2007
Liu ML, 2010, J BIOL CHEM, V285, P36387, DOI 10.1074/jbc.M110.169284
Lodato S, 2011, J NEUROSCI, V31, P4650, DOI 10.1523/JNEUROSCI.6580-10.2011
Markram H, 2004, NAT REV NEUROSCI, V5, P793, DOI 10.1038/nrn1519
Martin MS, 2010, J BIOL CHEM, V285, P9823, DOI 10.1074/jbc.M109.078568
Meikle L, 2007, J NEUROSCI, V27, P5546, DOI 10.1523/JNEUROSCI.5540-06.2007
Metin C, 2006, EUR J NEUROSCI, V23, P894, DOI 10.1111/j.1460-9568.2006.04630.x
Monory K, 2006, NEURON, V51, P455, DOI 10.1016/j.neuron.2006.07.006
Nery S, 2002, NAT NEUROSCI, V5, P1279, DOI 10.1038/nn971
Nie D, 2010, NAT NEUROSCI, V13, P163, DOI 10.1038/nn.2477
Oakley JC, 2009, P NATL ACAD SCI USA, V106, P3994, DOI 10.1073/pnas.0813330106
OSBORNE JP, 1991, ANN NY ACAD SCI, V615, P125, DOI 10.1111/j.1749-6632.1991.tb37754.x
Paxinos G., 2004, MOUSE BRAIN STEREOTA
Rudolph J, 2010, CELL ADHES MIGR, V4, P400, DOI 10.4161/cam.4.3.11640
Samoriski GM, 1997, J NEUROSCI, V17, P5581
Sarbassov DD, 2006, MOL CELL, V22, P159, DOI 10.1016/j.molcel.2006.03.029
Sarbassov DD, 2004, CURR BIOL, V14, P1296
Sawamura A, 2001, BRAIN RES, V911, P89, DOI 10.1016/S0006-8993(01)02732-9
Sharma A, 2010, J NEUROSCI, V30, P694, DOI 10.1523/JNEUROSCI.3696-09.2010
Stenman J, 2003, J NEUROSCI, V23, P167
Taki MM, 2009, NEUROIMAGE, V47, P1207, DOI 10.1016/j.neuroimage.2009.05.060
Thiele EA, 2004, J CHILD NEUROL, V19, P680
Tiveron MC, 2008, CURR OPIN NEUROBIOL, V18, P237, DOI 10.1016/j.conb.2008.06.004
TOUSSI HR, 1987, EUR J PHARMACOL, V137, P261, DOI 10.1016/0014-2999(87)90232-9
Uhlmann EJ, 2002, ANN NEUROL, V52, P285, DOI 10.1002/ana.10283
Valencia I, 2006, J CHILD NEUROL, V21, P1058, DOI 10.2310/7010.2006.00242
Veliscova J, 2005, NEUROBIOL DIS, V20, P752, DOI 10.1016/j.nbd.2005.05.007
Veliskova J, 2002, EPILEPTIC DISORD, V4, pS73
Wang YL, 2007, ANN NEUROL, V61, P139, DOI 10.1002/ana.21058
Way SW, 2009, HUM MOL GENET, V18, P1252, DOI 10.1093/hmg/ddp025
White R, 2001, ANN NEUROL, V49, P67, DOI 10.1002/1531-8249(200101)49:1<67::AID-ANA10>3.0.CO;2-L
Wiznitzer M, 2004, J CHILD NEUROL, V19, P675
Wonders CP, 2006, NAT REV NEUROSCI, V7, P687, DOI 10.1038/nrn1954
Wong M, 2001, PEDIATR NEUROL, V24, P89, DOI 10.1016/S0887-8994(00)00238-1
XU SG, 1991, BRAIN RES, V566, P108, DOI 10.1016/0006-8993(91)91687-V
Yee CL, 2009, J COMP NEUROL, V517, P37, DOI 10.1002/cne.22132
Yozu M, 2005, J NEUROSCI, V25, P7268, DOI 10.1523/JNEUROSCI.2072-05.2005
Zeng LH, 2009, J NEUROSCI, V29, P6964, DOI 10.1523/JNEUROSCI.0066-09.2009
Zerucha T, 2000, J NEUROSCI, V20, P709
Zhou J, 2009, J NEUROSCI, V29, P1773, DOI 10.1523/JNEUROSCI.5685-08.2009
NR 69
TC 21
Z9 21
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 1047-3211
J9 CEREB CORTEX
JI Cereb. Cortex
PD SEP
PY 2012
VL 22
IS 9
BP 2111
EP 2119
DI 10.1093/cercor/bhr300
PG 9
WC Neurosciences
SC Neurosciences & Neurology
GA 988QP
UT WOS:000307505900013
PM 22021912
ER
PT J
AU Karst, JS
Van Hecke, AV
AF Karst, Jeffrey S.
Van Hecke, Amy Vaughan
TI Parent and Family Impact of Autism Spectrum Disorders: A Review and
Proposed Model for Intervention Evaluation
SO CLINICAL CHILD AND FAMILY PSYCHOLOGY REVIEW
LA English
DT Review
DE Autism spectrum disorders; Parents; Caregivers; Families; Intervention
ID RANDOMIZED CONTROLLED-TRIAL; HIGH-FUNCTIONING AUTISM; PERVASIVE
DEVELOPMENTAL DISORDERS; SOCIAL-SKILLS INTERVENTIONS; QUALITY-OF-LIFE;
INTENSIVE BEHAVIORAL INTERVENTION; CHILD SYMPTOM SEVERITY;
YOUNG-CHILDREN; MENTAL-HEALTH; ASPERGER-SYNDROME
AB Raising a child with an autism spectrum disorder (ASD) can be an overwhelming experience for parents and families. The pervasive and severe deficits often present in children with ASD are associated with a plethora of difficulties in caregivers, including decreased parenting efficacy, increased parenting stress, and an increase in mental and physical health problems compared with parents of both typically developing children and children with other developmental disorders. In addition to significant financial strain and time pressures, high rates of divorce and lower overall family well-being highlight the burden that having a child with an ASD can place on families. These parent and family effects reciprocally and negatively impact the diagnosed child and can even serve to diminish the positive effects of intervention. However, most interventions for ASD are evaluated only in terms of child outcomes, ignoring parent and family factors that may have an influence on both the immediate and long-term effects of therapy. It cannot be assumed that even significant improvements in the diagnosed child will ameliorate the parent and family distress already present, especially as the time and expense of intervention can add further family disruption. Thus, a new model of intervention evaluation is proposed, which incorporates these factors and better captures the transactional nature of these relationships.
C1 [Karst, Jeffrey S.; Van Hecke, Amy Vaughan] Marquette Univ, Milwaukee, WI 53201 USA.
RP Karst, JS (reprint author), Marquette Univ, 604 N 16th St,Cramer Hall 307, Milwaukee, WI 53201 USA.
EM jeffrey.karst@mu.edu
CR Abidin RR, 1995, PARENTING STRESS IND
Allik H, 2006, HEALTH QUAL LIFE OUT, V4, DOI 10.1186/1477-7525-4-1
Anan RM, 2008, BEHAV INTERVENT, V23, P165, DOI 10.1002/bin.262
Baker BL, 2003, J INTELL DISABIL RES, V47, P217, DOI 10.1046/j.1365-2788.2003.00484.x
Baker JK, 2011, J FAM PSYCHOL, V25, P601, DOI 10.1037/a0024409
Bayat M, 2007, J INTELL DISABIL RES, V51, P702, DOI 10.1111/j.1365-2788.2007.00960.x
Beaumont R, 2008, J CHILD PSYCHOL PSYC, V49, P743, DOI 10.1111/j.1469-7610.2008.01920.x
BEBKO JM, 1987, J AUTISM DEV DISORD, V17, P565, DOI 10.1007/BF01486971
Begeer S, 2011, J AUTISM DEV DISORD, V41, P997, DOI 10.1007/s10803-010-1121-9
Benson PR, 2011, J AUTISM DEV DISORD, V41, P1675, DOI 10.1007/s10803-011-1198-9
Benson PR, 2006, J AUTISM DEV DISORD, V36, P685, DOI 10.1007/s10803-006-0112-3
Benson PR, 2011, AUTISM, V15, P65, DOI 10.1177/1362361309352777
Benson PR, 2009, J AUTISM DEV DISORD, V39, P350, DOI 10.1007/s10803-008-0632-0
Bibby Peter, 2002, Research in Developmental Disabilities, V23, P81, DOI 10.1016/S0891-4222(02)00095-1
Bolton PF, 2012, J AM ACAD CHILD PSY, V51, P249, DOI 10.1016/j.jaac.2011.12.009
Brobst JB, 2009, FOCUS AUTISM DEV DIS, V24, P38, DOI 10.1177/1088357608323699
Bromley J, 2004, AUTISM, V8, P409, DOI 10.1177/1362361304047224
BRONFENBRENNER U, 1986, DEV PSYCHOL, V22, P723, DOI 10.1037//0012-1649.22.6.723
BRONFENBRENNER U, 1979, AM PSYCHOL, V34, P844, DOI 10.1037//0003-066X.34.10.844
Brooks-Gunn J., 2000, HDB EARLY CHILDHOOD, P549
Brown HK, 2011, J AUTISM DEV DISORD, V41, P1291, DOI 10.1007/s10803-010-1148-y
Carter AS, 2009, J CLIN PSYCHOL, V65, P1270, DOI 10.1002/jclp.20634
Centers for Disease Control and Prevention, 2012, PREV AUT SPECTR DIS
Chamak B, 2011, AUTISM, V15, P83, DOI 10.1177/1362361309354756
Chambless DL, 1996, CLIN PSYCHOL, V49, P5
Coolican J, 2010, J CHILD PSYCHOL PSYC, V51, P1321, DOI 10.1111/j.1469-7610.2010.02326.x
Davis NO, 2008, J AUTISM DEV DISORD, V38, P1278, DOI 10.1007/s10803-007-0512-z
Dawson G, 2010, PEDIATRICS, V125, pE17, DOI 10.1542/peds.2009-0958
Drew A, 2002, EUR CHILD ADOLES PSY, V11, P266, DOI 10.1007/s00787-002-0299-6
Dritschel B, 2010, AUTISM, V14, P509, DOI 10.1177/1362361310368407
Duarte CS, 2005, AUTISM, V9, P416, DOI 10.1177/1362361305056081
Dunlap G, 1999, J ASSOC PERS SEVERE, V24, P222, DOI 10.2511/rpsd.24.3.222
Dunn ME, 2001, COMMUNITY MENT HLT J, V37, P39, DOI 10.1023/A:1026592305436
Ekas NV, 2010, J AUTISM DEV DISORD, V40, P1274, DOI 10.1007/s10803-010-0986-y
Estes A, 2009, AUTISM, V13, P375, DOI 10.1177/1362361309105658
Field S, 1999, FOCUS AUTISM OTHER D, V14, P36, DOI DOI 10.1177/108835769901400105
Freedman BH, 2012, J AUTISM DEV DISORD, V42, P539, DOI 10.1007/s10803-011-1269-y
Gabriels RL, 2001, AUTISM, V5, P407, DOI 10.1177/1362361301005004006
Gau SSF, 2012, RES AUTISM SPECT DIS, V6, P263, DOI 10.1016/j.rasd.2011.05.007
Gerard A. B., 1994, PARENT CHILD RELATIO
Giallo R, 2013, AUTISM, V17, P465, DOI 10.1177/1362361311416830
Glasberg BA, 2000, J AUTISM DEV DISORD, V30, P143, DOI 10.1023/A:1005411722958
Granger S, 2012, TOP EARLY CHILD SPEC, V32, P68, DOI 10.1177/0271121410393285
GRAY DE, 1994, SOCIOL HEALTH ILL, V16, P275, DOI 10.1111/1467-9566.ep11348729
Green J, 2010, LANCET, V375, P2152, DOI 10.1016/S0140-6736(10)60587-9
Greenspan S. I., 1997, J DEV LEARNING DISOR, V1, P1
Greenspan SI, 1999, J ASSOC PERS SEVERE, V24, P147, DOI 10.2511/rpsd.24.3.147
Grindle C, 2009, J AUTISM DEV DISORD, V39, P42, DOI 10.1007/s10803-008-0597-z
Gutstein S. E., 2002, FOCUS AUTISM OTHER D, V17, P161, DOI DOI 10.1177/10883576020170030601
Gutstein SE, 2007, AUTISM, V11, P397, DOI 10.1177/1362361307079603
Hall Heather R, 2011, Issues Compr Pediatr Nurs, V34, P4, DOI 10.3109/01460862.2011.555270
Hartley SL, 2011, AJIDD-AM J INTELLECT, V116, P81, DOI 10.1352/1944-7558-116.1.81
Hartley SL, 2010, J FAM PSYCHOL, V24, P449, DOI 10.1037/a0019847
Hastings RP, 2003, J INTELL DISABIL RES, V47, P231, DOI 10.1046/j.1365-2788.2003.00485.x
Hastings RP, 2002, AM J MENT RETARD, V107, P222, DOI 10.1352/0895-8017(2002)107<0222:BPOCWA>2.0.CO;2
Hastings RP, 2001, J AUTISM DEV DISORD, V31, P327, DOI 10.1023/A:1010799320795
Herring S, 2006, J INTELL DISABIL RES, V50, P874, DOI 10.1111/j.1365-2788.2006.00904.x
Higgins DJ, 2005, AUTISM, V9, P125, DOI 10.1177/1362361305051403
Hoagwood K, 1996, J AM ACAD CHILD PSY, V35, P1055, DOI 10.1097/00004583-199608000-00017
Hoagwood KE, 2005, J CHILD PSYCHOL PSYC, V46, P690, DOI 10.1111/j.1469-7610.2005.01451.x
Hoffman CD, 2009, FOCUS AUTISM DEV DIS, V24, P178, DOI 10.1177/1088357609338715
Howlin P, 1999, DEV MED CHILD NEUROL, V41, P834, DOI 10.1017/S0012162299001656
Ingersoll B, 2006, TOP EARLY CHILD SPEC, V26, P179, DOI 10.1177/02711214060260030501
Ingersoll B, 2011, RES AUTISM SPECT DIS, V5, P337, DOI 10.1016/j.rasd.2010.04.017
Ivey J. K., 2004, FOCUS AUTISM OTHER D, V19, P27, DOI DOI 10.1177/10883576040190010401
JACOBSON NS, 1991, J CONSULT CLIN PSYCH, V59, P12, DOI 10.1037//0022-006X.59.1.12
Johnson SA, 2009, J AUTISM DEV DISORD, V39, P1706, DOI 10.1007/s10803-009-0809-1
JOHNSTON C, 1989, J CLIN CHILD PSYCHOL, V18, P167, DOI 10.1207/s15374424jccp1802_8
Jones TL, 2005, CLIN PSYCHOL REV, V25, P341, DOI 10.1016/j.cpr.2004.12.004
Kaiser AP, 2003, INFANT YOUNG CHILD, V16, P9
Kalyva E, 2010, J AUTISM DEV DISORD, V40, P1202, DOI 10.1007/s10803-010-0978-y
Kamphaus R. W., 2006, PRQ PARENTING RELATI
Kasari C, 2010, CURR OPIN NEUROL, V23, P137, DOI 10.1097/WCO.0b013e32833775cd
Kasari C, 2010, J AUTISM DEV DISORD, V40, P1045, DOI 10.1007/s10803-010-0955-5
Kazdin A. E., 2003, EVIDENCE BASED PSYCH
Kazdin AE, 1998, J CONSULT CLIN PSYCH, V66, P19, DOI 10.1037/0022-006X.66.1.19
Keen D, 2010, RES AUTISM SPECT DIS, V4, P229, DOI 10.1016/j.rasd.2009.09.009
Kelly AB, 2008, J ABNORM CHILD PSYCH, V36, P1069, DOI 10.1007/s10802-008-9234-8
Khanna R, 2011, J AUTISM DEV DISORD, V41, P1214, DOI 10.1007/s10803-010-1140-6
Kheir N, 2012, AUTISM, V16, P293, DOI 10.1177/1362361311433648
Kim JM, 2004, TOP EARLY CHILD SPEC, V24, P31, DOI 10.1177/02711214040240010301
Knott F, 2006, AUTISM, V10, P609, DOI 10.1177/1362361306068510
Koegel LK, 1999, J ASSOC PERS SEVERE, V24, P174, DOI 10.2511/rpsd.24.3.174
KOEGEL LK, 1992, J APPL BEHAV ANAL, V25, P341, DOI 10.1901/jaba.1992.25-341
Koegel RL, 1996, J AUTISM DEV DISORD, V26, P347, DOI 10.1007/BF02172479
Koegel RL, 1999, SCHOOL PSYCHOL REV, V28, P576
KOEGEL RL, 1992, J AUTISM DEV DISORD, V22, P205, DOI 10.1007/BF01058151
KOEGEL RL, 1993, J APPL BEHAV ANAL, V26, P369, DOI 10.1901/jaba.1993.26-369
Koegel RL, 2003, EVIDENCE-BASED PSYCHOTHERAPIES FOR CHILDREN AND ADOLESCENTS, P341
Koenig K, 2009, J AUTISM DEV DISORD, V39, P1163, DOI 10.1007/s10803-009-0728-1
Krasny L, 2003, CHILD ADOL PSYCH CL, V12, P107, DOI 10.1016/S1056-4993(02)00051-2
Krauss M. W., 2000, HDB EARLY CHILDHOOD, V2th, P290
Kuhn JC, 2006, AM J ORTHOPSYCHIAT, V76, P564, DOI 10.1037/0002-9432.76.4.564
Lam SF, 2010, AUTISM, V14, P359, DOI 10.1177/1362361309346558
Larsson HJ, 2005, AM J EPIDEMIOL, V161, P916, DOI 10.1093/aje/kwi123
Laugeson EA, 2011, SOCIAL SKILLS FOR TEENAGERS WITH DEVELOPMENTAL AND AUTISM SPECTRUM DISORDERS, P1
Laugeson EA, 2009, J AUTISM DEV DISORD, V39, P596, DOI 10.1007/s10803-008-0664-5
Lecavalier L, 2006, J INTELL DISABIL RES, V50, P172, DOI 10.1111/j.1365-2788.2005.00732.x
Lee LC, 2008, J AUTISM DEV DISORD, V38, P1147, DOI 10.1007/s10803-007-0491-0
Leef J., 2005, AUTISM NEWSLINK, P14
Little Liza, 2002, Pediatr Nurs, V28, P565
Little L, 2006, MCN-AM J MATERN-CHIL, V31, P39, DOI 10.1097/00005721-200601000-00009
Lord C, 2010, SOCIAL POLICY REPORT, V24, P1
Lord C, 2005, J AUTISM DEV DISORD, V35, P695, DOI 10.1007/s10803-005-0017-6
Losh M, 2008, AM J MED GENET B, V147B, P424, DOI 10.1002/ajmg.b.30612
LOVAAS OI, 1987, J CONSULT CLIN PSYCH, V55, P3, DOI 10.1037/0022-006X.55.1.3
Lovaas OI, 2003, EVIDENCE-BASED PSYCHOTHERAPIES FOR CHILDREN AND ADOLESCENTS, P325
LOVAAS OI, 1973, J APPL BEHAV ANAL, V6, P131, DOI 10.1901/jaba.1973.6-131
Lyons AM, 2010, J CHILD FAM STUD, V19, P516, DOI 10.1007/s10826-009-9323-5
Mackintosh K., 2006, J AUTISM DEV DISORD, V36, P1065, DOI [10.1007/s10803-006-0139-5, DOI 10.1007/S10803-006-0139-5]
Mackintosh VH, 2012, FOCUS AUTISM DEV DIS, V27, P51, DOI 10.1177/1088357611423542
Mahoney G, 2003, TOPICS EARLY CHILD S, V23, P74, DOI DOI 10.1177/02711214030230020301
Mandell D. S., 2011, ARCH PEDIAT ADOL MED, V166, P68
Mandell DS, 2005, PEDIATRICS, V116, P1480, DOI 10.1542/peds.2005-0185
Mandell DS, 2007, AUTISM, V11, P111, DOI 10.1177/1362361307077506
MATHENY AP, 1995, J APPL DEV PSYCHOL, V16, P429, DOI 10.1016/0193-3973(95)90028-4
Matson JL, 2007, BEHAV MODIF, V31, P682, DOI 10.1177/0145445507301650
Matson ML, 2009, RES AUTISM SPECT DIS, V3, P868, DOI 10.1016/j.rasd.2009.02.003
McConachie H, 2007, J EVAL CLIN PRACT, V13, P120, DOI 10.1111/j.1365-2753.2006.00674.x
McIntyre LL, 2008, AM J MENT RETARD, V113, P356, DOI 10.1352/2008.113:356-368
Meirsschaut M, 2010, RES AUTISM SPECT DIS, V4, P661, DOI 10.1016/j.rasd.2010.01.002
Meltzer LJ, 2011, RES AUTISM SPECT DIS, V5, P361, DOI 10.1016/j.rasd.2010.05.001
Midence K., 1999, AUTISM, V3, P273, DOI [10.1177/1362361399003003005, DOI 10.1177/1362361399003003005]
Miles JH, 2003, J AUTISM DEV DISORD, V33, P403, DOI 10.1023/A:1025010828304
MILGRAM NA, 1988, J AUTISM DEV DISORD, V18, P415, DOI 10.1007/BF02212196
Minjarez MB, 2011, J AUTISM DEV DISORD, V41, P92, DOI 10.1007/s10803-010-1027-6
Minuchin S., 1981, FAMILY THERAPY TECHN
Moh TA, 2012, RES AUTISM SPECT DIS, V6, P293, DOI 10.1016/j.rasd.2011.05.011
Montes G, 2007, PEDIATRICS, V119, pE1040, DOI 10.1542/peds.2006-2819
Morrison J. Q., 2009, J POSTSECONDARY ED D, V22, P78
Mugno D, 2007, HEALTH QUAL LIFE OUT, V5, DOI 10.1186/1477-7525-5-22
Murray DS, 2009, LANG SPEECH HEAR SER, V40, P109, DOI 10.1044/0161-1461(2008/07-0089)
Nock M. K., 2001, J CHILD FAM STUD, V10, P155, DOI DOI 10.1023/A:1016699424731
Odom SL, 2010, J AUTISM DEV DISORD, V40, P425, DOI 10.1007/s10803-009-0825-1
Olsson MB, 2001, J INTELL DISABIL RES, V45, P535, DOI 10.1046/j.1365-2788.2001.00372.x
Oosterling I, 2010, J AUTISM DEV DISORD, V40, P1447, DOI 10.1007/s10803-010-1004-0
Orsmond GI, 2007, INTELLECT DEV DISAB, V45, P257, DOI 10.1352/1934-9556(2007)45[257:MOAAAW]2.0.CO;2
Osborne LA, 2008, J AUTISM DEV DISORD, V38, P1092, DOI 10.1007/s10803-007-0497-7
OZONOFF S, 1995, J AUTISM DEV DISORD, V25, P415, DOI 10.1007/BF02179376
Ozonoff S, 2005, J CLIN CHILD ADOLESC, V34, P523, DOI 10.1207/s15374424jccp3403_8
Pakenham KI, 2005, AUTISM, V9, P191, DOI 10.1177/1362361305049033
Phelps KW, 2009, J INTELLECT DEV DIS, V34, P133, DOI 10.1080/13668250902845236
Pillay Mini, 2011, Clin Child Psychol Psychiatry, V16, P5, DOI 10.1177/1359104509340945
Pottie CG, 2009, J PEDIATR PSYCHOL, V34, P419, DOI 10.1093/jpepsy/jsn094
Pottie CG, 2008, J FAM PSYCHOL, V22, P855, DOI 10.1037/a0013604
QUITTNER AL, 1990, J PERS SOC PSYCHOL, V59, P1266, DOI 10.1037//0022-3514.59.6.1266
RADLOFF L S, 1977, Applied Psychological Measurement, V1, P385, DOI 10.1177/014662167700100306
Rao PA, 2009, BEHAV MODIF, V33, P437, DOI 10.1177/0145445509336427
Rao PA, 2008, J AUTISM DEV DISORD, V38, P353, DOI 10.1007/s10803-007-0402-4
Regehr K, 2009, BEHAV INTERVENT, V24, P237, DOI 10.1002/bin.291
Reichow B, 2010, J AUTISM DEV DISORD, V40, P149, DOI 10.1007/s10803-009-0842-0
Remington B, 2007, AM J MENT RETARD, V112, P418, DOI 10.1352/0895-8017(2007)112[418:EIBIOF]2.0.CO;2
Rezendes DL, 2011, AUTISM RES TREATMENT, DOI [10.1155/2011/395190, DOI 10.1155/2011/395190]
Rivers JW, 2003, J AUTISM DEV DISORD, V33, P383, DOI 10.1023/A:1025006727395
Roberts Deborah, 2010, Community Pract, V83, P27
Rocha ML, 2007, J EARLY INTERVENTION, V29, P154, DOI 10.1177/105381510702900207
RODRIGUE JR, 1990, J CLIN CHILD PSYCHOL, V19, P371, DOI 10.1207/s15374424jccp1904_9
Rogers SJ, 2008, J CLIN CHILD ADOLESC, V37, P8, DOI 10.1080/15374410701817808
Rogers SJ, 2000, J AUTISM DEV DISORD, V30, P399, DOI 10.1023/A:1005543321840
Ruble L, 2008, TOP EARLY CHILD SPEC, V28, P158, DOI 10.1177/0271121408323009
Rutter ML, 2011, J AUTISM DEV DISORD, V41, P395, DOI 10.1007/s10803-011-1184-2
Sameroff AJ, 2000, HDB EARLY CHILDHOOD, V2nd, P135, DOI DOI 10.1017/CBO9780511529320.009
Sansosti FJ, 2010, PSYCHOL SCHOOLS, V47, P257, DOI 10.1002/pits.20469
Sawyer MG, 2010, J AUTISM DEV DISORD, V40, P620, DOI 10.1007/s10803-009-0912-3
Schaaf R. C., 2011, AUTISM, P1, DOI [10.1177/1352351310386505, DOI 10.1177/1352351310386505]
Schertz H. H., 2010, TOP EARLY CHILD SPEC, P1
Schertz HH, 2007, J AUTISM DEV DISORD, V37, P1562, DOI 10.1007/s10803-006-0290-z
Schieve LA, 2007, PEDIATRICS, V119, pS114, DOI 10.1542/peds.2006-2089Q
Schieve LA, 2011, DISABIL HEALTH J, V4, P143, DOI 10.1016/j.dhjo.2010.09.002
SCHOPLER E, 1982, J AM ACAD CHILD PSY, V21, P262, DOI 10.1016/S0002-7138(09)60881-5
SCHOPLER E, 1971, J AUTISM CHILD SCHIZ, V1, P87, DOI 10.1007/BF01537746
Schreiber C, 2011, J POSIT BEHAV INTERV, V13, P49, DOI 10.1177/1098300709359027
Seltzer MM, 2001, AM J MENT RETARD, V106, P265
Sharpley CF, 1997, J INTELLECT DEV DIS, V22, P19, DOI 10.1080/13668259700033261
Sheras P. L., 1998, SIPA STRESS INDEX PA
Sherer MR, 2005, J CONSULT CLIN PSYCH, V73, P525, DOI 10.1037/0022-006X.73.3.525
Shu BC, 2009, AUTISM, V13, P81, DOI 10.1177/1362361307098517
Shyu YIL, 2010, J AUTISM DEV DISORD, V40, P1323, DOI 10.1007/s10803-010-0991-1
Siller M, 2002, J AUTISM DEV DISORD, V32, P77, DOI 10.1023/A:1014884404276
Silva LMT, 2012, J AUTISM DEV DISORD, V42, P566, DOI 10.1007/s10803-011-1274-1
Singer GHS, 2006, AM J MENT RETARD, V111, P155, DOI 10.1352/0895-8017(2006)111[155:MOCSOD]2.0.CO;2
Singh NN, 2006, J EMOT BEHAV DISORD, V14, P169, DOI 10.1177/10634266060140030401
Sivberg B, 2002, AUTISM, V6, P397, DOI 10.1177/1362361302006004006
Smith IM, 2010, AJIDD-AM J INTELLECT, V115, P504, DOI [10.1352/1944-7558-115.6.504, 10.1352/194475581156504]
Smith LE, 2010, J AUTISM DEV DISORD, V40, P167, DOI 10.1007/s10803-009-0844-y
Smith T, 2007, J AUTISM DEV DISORD, V37, P354, DOI 10.1007/s10803-006-0173-3
Smith T, 1998, INFANT YOUNG CHILD, V10, P67
Smith T, 2000, RES DEV DISABIL, V21, P297, DOI 10.1016/S0891-4222(00)00043-3
Sofronoff K, 2004, AUTISM, V8, P301, DOI 10.1177/136261304045215
Sofronoff K, 2002, AUTISM, V6, P271, DOI 10.1177/1362361302006003005
Solomon M, 2004, J AUTISM DEV DISORD, V34, P649, DOI 10.1007/s10803-004-5286-y
Solomon M, 2008, J AUTISM DEV DISORD, V38, P1767, DOI 10.1007/s10803-008-0567-5
Solomon R, 2007, AUTISM, V11, P205, DOI 10.1177/1362361307076842
Stewart K. K., 2007, CLIN CASE STUDIES, V6, P252, DOI DOI 10.1177/1534650106286940
Stoddart K, 1999, AUTISM, V3, P255, DOI DOI 10.1177/1362361399003003004
Tehee E, 2009, J APPL RES INTELLECT, V22, P34, DOI 10.1111/j.1468-3148.2008.00437.x
Jensen PS, 1999, ARCH GEN PSYCHIAT, V56, P1088
Tomanik S, 2004, J INTELLECT DEV DIS, V29, P16, DOI 10.1080/13668250410001662892
Tonge B, 2006, J AM ACAD CHILD PSY, V45, P561, DOI 10.1097/01.chi.0000205701.48324.26
Vismara LA, 2008, J EARLY INTERVENTION, V31, P91, DOI 10.1177/1053815108325578
Vismara LA, 2009, AUTISM, V13, P93, DOI 10.1177/1362361307098516
Volkmar FR, 2003, LANCET, V362, P1133, DOI 10.1016/S0140-6736(03)14471-6
Wang PS, 2008, J POLICY PRACT INTEL, V5, P96, DOI 10.1111/j.1741-1130.2008.00154.x
Wang PS, 2011, J AUTISM DEV DISORD, V41, P783, DOI 10.1007/s10803-010-1099-3
Warren ZE, 2011, PEDIATRICS, V127, P1303
Weiss JA, 2012, AUTISM, V16, P261, DOI 10.1177/1362361311422708
Weiss MJ, 2002, AUTISM, V6, P115, DOI 10.1177/1362361302006001009
White SW, 2007, J AUTISM DEV DISORD, V37, P1858, DOI 10.1007/s10803-006-0320-x
White SW, 2010, CLIN CHILD FAM PSYCH, V13, P77, DOI 10.1007/s10567-009-0062-3
Whittingham K, 2009, J ABNORM CHILD PSYCH, V37, P469, DOI 10.1007/s10802-008-9285-x
Whittingham K, 2008, BEHAV CHANGE, V25, P201
WOLF LC, 1989, J AUTISM DEV DISORD, V19, P157, DOI 10.1007/BF02212727
Wood JJ, 2009, J AUTISM DEV DISORD, V39, P1608, DOI 10.1007/s10803-009-0791-7
Woodgate RL, 2008, QUAL HEALTH RES, V18, P1075, DOI 10.1177/1049732308320112
Yamada A, 2007, PSYCHIAT CLIN NEUROS, V61, P651, DOI 10.1111/j.1440-1819.2007.01736.x
Zaidman-Zait A, 2011, AUTISM RES, V4, P336, DOI 10.1002/aur.213
NR 216
TC 26
Z9 27
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1096-4037
J9 CLIN CHILD FAM PSYCH
JI Clin. Child Fam. Psychol. Rev.
PD SEP
PY 2012
VL 15
IS 3
BP 247
EP 277
DI 10.1007/s10567-012-0119-6
PG 31
WC Psychology, Clinical
SC Psychology
GA 988RF
UT WOS:000307507600005
PM 22869324
ER
PT J
AU Scheflen, SC
Freeman, SFN
Paparella, T
AF Scheflen, Sarah Clifford
Freeman, Stephanny F. N.
Paparella, Tanya
TI Using Video Modeling to Teach Young Children with Autism Developmentally
Appropriate Play and Connected Speech
SO EDUCATION AND TRAINING IN AUTISM AND DEVELOPMENTAL DISABILITIES
LA English
DT Article
ID SYMBOLIC PLAY; JOINT ATTENTION; PRETEND PLAY; LANGUAGE; SKILLS;
INTERVENTIONS; DISABILITIES
AB Four children with autism were taught play skills through the use of video modeling. Video instruction was used to model play and appropriate language through a developmental sequence of play levels integrated with language techniques. Results showed that children with autism could successfully use video modeling to learn how to play appropriately with toys in both structured and generalized situations, although the speed with which the progression was made was not uniform. In addition, some children showed an increase in the frequency and complexity of their language used when playing.
C1 [Scheflen, Sarah Clifford] Univ Calif Los Angeles, Semel Inst Neurosci & Human Behav 77 447, Los Angeles, CA 90024 USA.
RP Scheflen, SC (reprint author), Univ Calif Los Angeles, Semel Inst Neurosci & Human Behav 77 447, 760 Westwood Plaza, Los Angeles, CA 90024 USA.
CR American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th
BARONCOHEN S, 1987, BRIT J DEV PSYCHOL, V5, P139
Barton EE, 2008, TOP EARLY CHILD SPEC, V28, P109, DOI 10.1177/0271121408318799
Bellini S, 2007, EXCEPT CHILDREN, V73, P264
CHARLOP MH, 1989, J APPL BEHAV ANAL, V22, P275, DOI 10.1901/jaba.1989.22-275
Charlop-Christy MH, 2000, J AUTISM DEV DISORD, V30, P537, DOI 10.1023/A:1005635326276
Charlop-Christy MH, 2003, J POSIT BEHAV INTERV, V5, P12, DOI 10.1177/10983007030050010101
Corbett C. A., 2005, J EARLY INTENSIVE BE, V2, P2
D'Ateno P, 2003, J POSIT BEHAV INTERV, V5, P5, DOI 10.1177/10983007030050010801
Detrich R, 1999, SCHOOL PSYCHOL REV, V28, P608
Dorwick P. W., 1991, PRACTICAL GUIDE USIN
HARING TG, 1987, J APPL BEHAV ANAL, V20, P89, DOI 10.1901/jaba.1987.20-89
Hermansen E, 2007, ED TREATMENT CHILDRE, V30, P183, DOI DOI 10.1353/ETC.2007.0029
Hine JF, 2006, TOP EARLY CHILD SPEC, V26, P83, DOI 10.1177/02711214060260020301
JARROLD C, 1993, J AUTISM DEV DISORD, V23, P281, DOI 10.1007/BF01046221
Kasari C, 2006, J CHILD PSYCHOL PSYC, V47, P611, DOI 10.1111/j.1469-7610.2005.01567.x
Kasari C, 2001, INT REV RES MENT RET, V23, P207
Lifter K., 2000, PLAY DIAGNOSIS ASSES, P228
LIFTER K, 1993, J EARLY INTERVENTION, V17, P139
Lord C, 1985, COMMUNICATION PROBLE, P257
MacDonald R, 2005, BEHAV INTERVENT, V20, P225, DOI 10.1002/bin.197
Nikopoulos CK, 2003, BEHAV INTERVENT, V18, P87, DOI 10.1002/bin.129
Nikopoulos CK, 2004, J APPL BEHAV ANAL, V37, P93, DOI 10.1901/jaba.2004.37-93
Paparella T, 2004, INFANT YOUNG CHILD, V17, P269
Paterson CR, 2007, BEHAV MODIF, V31, P660, DOI 10.1177/0145445507301651
Reagon K. A., 2006, EDUC TREAT CHILD, V29, P517
Retherford K., 1993, GUIDE ANAL LANGUAGE
Rutter M., 1983, HDB CHILD PSYCHOL, P775
Schopler E, 1990, PSYCHOEDUCATIONAL PR
SIGMAN M, 1986, J CHILD PSYCHOL PSYC, V27, P647, DOI 10.1111/j.1469-7610.1986.tb00189.x
SIGMAN M, 1984, DEV PSYCHOL, V20, P293, DOI 10.1037/0012-1649.20.2.293
Stahmer AC, 2003, AUTISM, V7, P401, DOI 10.1177/1362361303007004006
Stanley GC, 2007, J AUTISM DEV DISORD, V37, P1215, DOI 10.1007/s10803-006-0263-2
Taylor BA, 1999, J DEV PHYS DISABIL, V11, P253, DOI 10.1023/A:1021800716392
Thorpe J., 1995, J AUTISM DEV DISORD, V25, P265
UNGERER JA, 1981, J AM ACAD CHILD PSY, V20, P318, DOI 10.1016/S0002-7138(09)60992-4
WHYTE J, 1989, IRISH J PSYCHOL, V10, P317
Wolf M., 1973, J APPL BEHAV ANAL, V11, P203
Wullf S. B., 1985, J APPL BEHAV ANAL, V15, P139
Zihni F., 2005, AZ METHOD USE VIDEO
Zimmerman I., 2002, PRESCHOOL LANGUAGE S, V4th
NR 41
TC 3
Z9 3
PU COUNCIL EXCEPTIONAL CHILDREN
PI ARLINGTON
PA 1110 N GLEBE RD, ARLINGTON, VA 22201-5704 USA
SN 2154-1647
J9 EDUC TRAIN AUTISM DE
JI Educ. Train. Autism Dev. Disabil.
PD SEP
PY 2012
VL 47
IS 3
BP 302
EP 318
PG 17
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA 983OT
UT WOS:000307129300005
ER
PT J
AU Shurr, J
Taber-Doughty, T
AF Shurr, Jordan
Taber-Doughty, Teresa
TI Increasing Comprehension for Middle School Students with Moderate
Intellectual Disability on Age-Appropriate Texts
SO EDUCATION AND TRAINING IN AUTISM AND DEVELOPMENTAL DISABILITIES
LA English
DT Article
ID READING-COMPREHENSION; STRUGGLING READERS; CHILDREN; WORD;
COMMUNICATION; INSTRUCTION; CURRICULUM; EDUCATION; LITERATE; AUTISM
AB Students with moderate intellectual disability experience a lack of comparable access to literature as compared to their nondisabled peers (Browder et al., 2009; Kliewer, 1998). Problems in access for many of these students may be attributed to low expectations and inadequate support on behalf of students as well as a lack of sufficient literacy skills instruction. Given these issues, the literature students are able to access often is not representative of their chronological age. Literacy interventions such as read-alouds have been successfully used in special and general education alike to provide students access to literature beyond their present skill level. Using a multiple-probe design, investigators read typical age-appropriate texts and examined the effectiveness of pairing texts with the picture symbols and discussion in improving student comprehension. Discussion and implications of the findings within this study are included.
C1 [Shurr, Jordan] Cent Michigan Univ, Dept Counseling & Special Educ, Mt Pleasant, MI 48859 USA.
[Taber-Doughty, Teresa] Purdue Univ, W Lafayette, IN 47907 USA.
RP Shurr, J (reprint author), Cent Michigan Univ, Dept Counseling & Special Educ, 321 Educ & Human Serv Bldg, Mt Pleasant, MI 48859 USA.
EM shurr.jordan@gmail.com
CR Al Otaiba S., 2004, TEACHING EXCEPTIONAL, V36, P28
Allor JH, 2010, EDUC TRAIN AUTISM DE, V45, P3
Bellon ML, 2000, FOCUS AUTISM OTHER D, V15, P52, DOI DOI 10.1177/108835760001500107
Boning R. A., 1997, SRA SPECIFIC SKILLS
Browder D, 2009, REM SPEC EDUC, V30, P269, DOI 10.1177/0741932508315054
Browder DM, 2008, RES PRACT PERS SEV D, V33, P3
Browder DM, 2007, J SPEC EDUC, V41, P2, DOI 10.1177/00224669070410010101
Browder DM, 1998, J SPEC EDUC, V32, P130
Downing J. E, 2005, TEACHING LITERACY ST
ERICKSON KA, 1995, READ TEACH, V48, P676
Hibbing AN, 2003, READ TEACH, V56, P758
HOOVER WA, 1990, READ WRIT, V2, P127, DOI 10.1007/BF00401799
Horner RH, 2005, EXCEPT CHILDREN, V71, P165
Janks H, 2009, LANG CULT TEACH, P1
Joseph LM, 2003, EDUC TRAIN MENT RET, V38, P192
Kennedy C, 2005, SINGLE CASE DESIGNS
Kliewer C, 2006, AM EDUC RES J, V43, P163, DOI 10.3102/00028312043002163
Kliewer C, 1998, EXCEPT CHILDREN, V64, P167
Kliewer C, 1999, EXCEPT CHILDREN, V66, P85
Kluth P, 2003, READ TEACH, V56, P532
Kucan L, 1997, REV EDUC RES, V67, P271, DOI 10.3102/00346543067003271
Lawhon T., 2002, EARLY CHILDHOOD ED J, V30, P113, DOI 10.1023/A:1021253319248
Light JC, 1998, J COMMUN DISORD, V31, P153, DOI 10.1016/S0021-9924(97)00087-7
Liu J, 2004, TESOL QUART, V38, P225
McGraw Hill, SRA SKILLS SERIES BR
Moats L., 2002, LD ONLINE
Piontek M. E., 2008, BEST PRACTICES DESIG
Sevcik R. A., 1991, AUGMENTATIVE ALTERNA, V7, P161, DOI 10.1080/0963828050077804
Skotko BG, 2004, EXCEPT CHILDREN, V70, P145
Slater J. M., 2002, J SPECIAL ED TECHNOL, V17, P58
Trela K., 2007, FOCUS AUTISM OTHER D, V22, P206, DOI DOI 10.1177/10883576070220040301
Turnbull A., 2010, EXCEPTIONAL LIVES SP
Waugh RE, 2009, RES DEV DISABIL, V30, P1435, DOI 10.1016/j.ridd.2009.07.004
Wehmeyer ML, 2006, RES PRACT PERS SEV D, V31, P322
NR 34
TC 0
Z9 0
PU COUNCIL EXCEPTIONAL CHILDREN
PI ARLINGTON
PA 1110 N GLEBE RD, ARLINGTON, VA 22201-5704 USA
SN 2154-1647
J9 EDUC TRAIN AUTISM DE
JI Educ. Train. Autism Dev. Disabil.
PD SEP
PY 2012
VL 47
IS 3
BP 359
EP 372
PG 14
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA 983OT
UT WOS:000307129300009
ER
PT J
AU Hua, YJ
Hendrickson, JM
Therrien, WJ
Woods-Groves, S
Ries, PS
Shaw, JJ
AF Hua, Youjia
Hendrickson, Jo M.
Therrien, William J.
Woods-Groves, Suzanne
Ries, Pamela S.
Shaw, Julia J.
TI Effects of Combined Reading and Question Generation on Reading Fluency
and Comprehension of Three Young Adults With Autism and Intellectual
Disability
SO FOCUS ON AUTISM AND OTHER DEVELOPMENTAL DISABILITIES
LA English
DT Article
DE young adults; autism; reading intervention; comprehension; factual;
inferential
ID LEARNING-DISABILITIES; COGNITIVE DISABILITIES; SPECTRUM DISORDERS;
STUDENTS; STRATEGIES; INTERVENTIONS; INDIVIDUALS; INSTRUCTION; PROGRESS;
CHILDREN
AB Reread-Adapt and Answer-Comprehend (RAAC) is a reading intervention designed to target fluency and comprehension for students with disabilities. Previous researchers have demonstrated the effectiveness of the intervention for students with learning disabilities. This study extended the research by using the RAAC intervention with three postsecondary students with autism spectrum disorder. In the context of a multiple baseline across participants design, the results can be interpreted to conclude that the RAAC intervention may improve oral reading fluency and comprehension for young adults with autism. Using the linear weekly growth model based on the slope, the authors calculated realistic and ambitious goals. Participants' fluency gains exceeded the ambitious levels of growth and transferred to unpracticed passages. In addition, all participants correctly answered more factual and inferential comprehension questions during the intervention.
C1 [Hua, Youjia] Univ Iowa, Dept Teaching & Learning, Lindquist Ctr N256, Iowa City, IA 52242 USA.
RP Hua, YJ (reprint author), Univ Iowa, Dept Teaching & Learning, Lindquist Ctr N256, Iowa City, IA 52242 USA.
EM youjia-hua@uiowa.edu
CR Browder DM, 2006, EXCEPT CHILDREN, V72, P392
Bryant DP, 2000, LEARN DISABILITY Q, V23, P238, DOI 10.2307/1511347
Chard DJ, 2002, J LEARN DISABIL-US, V35, P386, DOI 10.1177/00222194020350050101
Chharbra V., 2004, VOICE EVIDENCE READI, P3
DAVEY B, 1986, J EDUC PSYCHOL, V78, P256, DOI 10.1037/0022-0663.78.4.256
Fuchs D., 2003, HDB LEARNING DISABIL, P235
Fuchs L. S., 2001, SCI STUD READ, V5, P239, DOI DOI 10.1207/S1532799XSSR0503_3
FUCHS LS, 1992, SCHOOL PSYCHOL REV, V21, P45
Fuchs L. S., 1982, DEV GOALS OBJECTIVES
FUCHS LS, 1989, EXCEPT CHILDREN, V55, P429
FUCHS LS, 1993, SCHOOL PSYCHOL REV, V22, P27
Gersten R, 2001, REV EDUC RES, V71, P279, DOI 10.3102/00346543071002279
Hasbrouck J. E., 1992, TEACHING EXCEPTIONAL, V24, P41
HOMAN SP, 1993, J EDUC RES, V87, P94
Hua YJ, 2012, EDUC TRAIN AUTISM DE, V47, P72
Kazdin A. E., 2010, SINGLE CASE RES DESI
LABERGE D, 1974, COGNITIVE PSYCHOL, V6, P293, DOI 10.1016/0010-0285(74)90015-2
Mastropieri MA, 1997, REM SPEC EDUC, V18, P197
Mathes P. G., 1993, LEARNING DISABILITIE, V8, P233
Morgan P., 2011, J SPECIAL ED
Nation K, 1999, PSYCHOL BULL, V125, P338, DOI 10.1037/0033-2909.125.3.338
Nation K, 2006, J AUTISM DEV DISORD, V36, P911, DOI 10.1007/s10803-006-0130-1
National Institute of Child Health and Human Development, 2000, TEACH CHILDR READ EV
National Research Council, 2001, ED CHILDR AUT
O'Connor IM, 2004, J AUTISM DEV DISORD, V34, P115, DOI 10.1023/B:JADD.0000022603.44077.6b
Ramps D., 1989, ED TREATMENT CHILDRE, V12, P38
RASHOTTE CA, 1985, READ RES QUART, V20, P180, DOI 10.1598/RRQ.20.2.4
SAMUELS SJ, 1979, READ TEACH, V32, P403
Skinner C. H., 1989, ED TREATMENT CHILDRE, V12, P123
Tawney J. W., 1984, SINGLE SUBJECT RES S
Therrien W. J., 2006, LEARNING DISABILITIE, V21, P89, DOI DOI 10.1111/J.1540-5826.2006.00209.X
Therrien W. J., 2008, LEARNING DISABILITIE, V15, P33
Therrien WJ, 2004, REM SPEC EDUC, V25, P252, DOI 10.1177/07419325040250040801
University of Oregon, 2005, DYN IND BAS EARL LIT
Wexler J, 2008, READ WRIT, V21, P317, DOI 10.1007/s11145-007-9085-7
Whalon KJ, 2009, FOCUS AUTISM DEV DIS, V24, P3, DOI 10.1177/1088357608328515
NR 36
TC 2
Z9 2
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1088-3576
J9 FOCUS AUTISM DEV DIS
JI Focus Autism Dev. Disabil.
PD SEP
PY 2012
VL 27
IS 3
BP 135
EP 146
DI 10.1177/1088357612448421
PG 12
WC Education, Special; Psychology, Developmental; Rehabilitation
SC Education & Educational Research; Psychology; Rehabilitation
GA 987WS
UT WOS:000307449200001
ER
PT J
AU Lerner, MD
Mikami, AY
AF Lerner, Matthew D.
Mikami, Amori Y.
TI A Preliminary Randomized Controlled Trial of Two Social Skills
Interventions for Youth With High-Functioning Autism Spectrum Disorders
SO FOCUS ON AUTISM AND OTHER DEVELOPMENTAL DISABILITIES
LA English
DT Article
DE high-functioning autism; social skills intervention;
randomized-controlled trial; treatment effectiveness evaluation;
psychotherapy research
ID CONTROLLED CLINICAL-TRIALS; CHILDREN; PROGRAM; PSYCHOTHERAPIES;
METAANALYSIS; INDIVIDUALS; ADOLESCENTS; FRIENDSHIP; OUTCOMES; THERAPY
AB This study examined the effects of two social skills interventions, Sociodramatic Affective Relational Intervention (SDARI) and Skillstreaming, to compare their treatment mechanisms, social performance- and knowledge-training. A total of 13 youth with autism spectrum disorders were randomly assigned to 4 weeks of 1-day/week SDARI or Skillstreaming. Groups were matched on parent and child demographics, and intervention staff training. Participants were assessed on social behavior during treatment sessions, peer sociometrics, staff-reported social skills, and parent-reported social skill generalization. Results indicated that both groups increased in reciprocated friendship nominations and staff-reported social skills. Relative to Skillstreaming participants, SDARI participants liked and interacted more with each other after a single session. However, Skillstreaming participants increased in peer liking and interaction over the course of the intervention; SDARI participants decreased slightly. Parents reported no change in social functioning at home. Implications for research and practice are discussed.
C1 [Lerner, Matthew D.] Univ Virginia, Dept Psychol, Charlottesville, VA 22904 USA.
[Mikami, Amori Y.] Univ British Columbia, Vancouver, BC V5Z 1M9, Canada.
RP Lerner, MD (reprint author), Univ Virginia, Dept Psychol, 102 Gilmer Hall,POB 400400, Charlottesville, VA 22904 USA.
EM mdl6e@virginia.edu
CR Bagwell CL, 1998, CHILD DEV, V69, P140, DOI 10.1111/j.1467-8624.1998.tb06139.x
Barry TD, 2003, J AUTISM DEV DISORD, V33, P685, DOI 10.1023/B:JADD.0000006004.86556.e0
Baskin TW, 2003, J CONSULT CLIN PSYCH, V71, P973, DOI 10.1037/0022-006X.71.6.973
Bauminger N, 2007, J AUTISM DEV DISORD, V37, P1593, DOI 10.1007/s10803-006-0245-4
Bauminger N, 2008, J ABNORM CHILD PSYCH, V36, P135, DOI 10.1007/s10802-007-9156-x
Bauminger N, 2002, J AUTISM DEV DISORD, V32, P283, DOI 10.1023/A:1016378718278
Bauminger N, 2007, J AUTISM DEV DISORD, V37, P1605, DOI 10.1007/s10803-006-0246-3
Carter A., 2005, HDB AUTISM PERVASIVE, P312
Cicchetti D. V., 1994, PSYCHOL ASSESSMENT, V6, P284, DOI [DOI 10.1037/1040-3590.6.4.284, 10.1037/1040-3590.6.4.284]
COIE JD, 1982, DEV PSYCHOL, V18, P557, DOI 10.1037/0012-1649.18.4.557
Constantino JN, 2005, SOCIAL RESPONSIVENES
Corbett BA, 2011, J AUTISM DEV DISORD, V41, P505, DOI 10.1007/s10803-010-1064-1
Corsello C, 2007, J CHILD PSYCHOL PSYC, V48, P932, DOI 10.1111/j.1469-7610.2007.01762.x
Dane AV, 1998, CLIN PSYCHOL REV, V18, P23, DOI 10.1016/S0272-7358(97)00043-3
Feingold A, 2009, PSYCHOL METHODS, V14, P43, DOI 10.1037/a0014699
Fleming L. R., 1977, THESIS SYRACUSE U NY
Goldstein A. P., 1997, SKILLSTREAMING ADOLE
Gresham F. M., 1990, SOCIAL SKILLS RATING
Gresham FM, 1997, ED TREATMENT CHILDRE, V20, P233
Guli L. A., 2008, SOCIAL COMPETENCE IN
GUTRIDE ME, 1974, J CLIN PSYCHOL, V30, P277, DOI 10.1002/1097-4679(197407)30:3<277::AID-JCLP2270300316>3.0.CO;2-F
Gutstein SE, 2007, AUTISM, V11, P397, DOI 10.1177/1362361307079603
Hoza B, 2005, J CLIN CHILD ADOLESC, V34, P74, DOI 10.1207/s15374424jccp3401_7
Kazdin AE, 2007, ANNU REV CLIN PSYCHO, V3, P1, DOI 10.1146/annurev.clinpsy.3.022806.091432
Kroeger KA, 2007, J AUTISM DEV DISORD, V37, P808, DOI 10.1007/s10803-006-0207-x
Laugeson EA, 2009, J AUTISM DEV DISORD, V39, P596, DOI 10.1007/s10803-008-0664-5
Legoff DB, 2006, AUTISM, V10, P317, DOI 10.1177/1362361306064403
LeGoff DB, 2004, J AUTISM DEV DISORD, V34, P557, DOI 10.1007/s10803-004-2550-0
Lerner M. D., 2007, SPOTLIGHT PROGRAM MA
Lerner M. D., 2007, J DEV PROCESSES, V2, P91
Lerner M. D., 2009, INT M AUT RES CHIC I
Lerner M. D., 2009, ASS PSYCH SCI ANN CO
Lerner MD, 2011, AUTISM, V15, P21, DOI 10.1177/1362361309353613
Lopata C, 2010, J AUTISM DEV DISORD, V40, P1297, DOI 10.1007/s10803-010-0989-8
LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
Lord C., 1999, MANUAL AUTISM DIAGNO
Matson JL, 2007, BEHAV MODIF, V31, P682, DOI 10.1177/0145445507301650
MESIBOV GB, 1984, J AUTISM DEV DISORD, V14, P395, DOI 10.1007/BF02409830
Pierce A., 2010, PUTTING SPOTLI UNPUB
Rao PA, 2008, J AUTISM DEV DISORD, V38, P353, DOI 10.1007/s10803-007-0402-4
Reichow B, 2010, J AUTISM DEV DISORD, V40, P149, DOI 10.1007/s10803-009-0842-0
Rotheram-Fuller E, 2010, J CHILD PSYCHOL PSYC, V51, P1227, DOI 10.1111/j.1469-7610.2010.02289.x
Rutter M., 2005, SCQ SOCIAL COMMUNICA
Smith T, 2007, J AUTISM DEV DISORD, V37, P354, DOI 10.1007/s10803-006-0173-3
Wampold BE, 1997, PSYCHOL BULL, V122, P203, DOI 10.1037/0033-2909.122.3.203
Westen D, 2004, PSYCHOL BULL, V130, P631, DOI 10.1037/0033-2909.130.4.631
Westen D, 2005, PSYCHOL BULL, V131, P427, DOI 10.1037/0033-2909.131.3.427
White SW, 2007, J AUTISM DEV DISORD, V37, P1858, DOI 10.1007/s10803-006-0320-x
NR 48
TC 7
Z9 7
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1088-3576
J9 FOCUS AUTISM DEV DIS
JI Focus Autism Dev. Disabil.
PD SEP
PY 2012
VL 27
IS 3
BP 147
EP 157
DI 10.1177/1088357612450613
PG 11
WC Education, Special; Psychology, Developmental; Rehabilitation
SC Education & Educational Research; Psychology; Rehabilitation
GA 987WS
UT WOS:000307449200002
ER
PT J
AU Pennington, RC
Delano, ME
AF Pennington, Robert C.
Delano, Monica E.
TI Writing Instruction for Students With Autism Spectrum Disorders: A
Review of Literature
SO FOCUS ON AUTISM AND OTHER DEVELOPMENTAL DISABILITIES
LA English
DT Review
DE autism spectrum disorders; writing instruction; evidence-based practice;
review
ID ASPERGER-SYNDROME; DEVELOPMENTAL-DISABILITIES; PLANNING INSTRUCTION;
ADOLESCENT STUDENTS; SPECIAL-EDUCATION; CHILDREN; INDIVIDUALS;
METAANALYSIS; COMMUNICATION; INTERVENTION
AB Historically, learners with autism spectrum disorders (ASD) have not had access to the general education curriculum. Current legislation mandates that all children, including children with ASD, have access to and make progress in the general education curriculum. This article contains a review of the literature on writing instruction for children with ASD. Investigation yielded 15 studies with 29 participants with ASD ages 4 to 21 years. Based on the studies reviewed, we concluded that students with ASD benefit from explicit writing instruction, but more research is needed to establish an evidence-based set of practices to guide educators in the development of effective writing programs for this population of students. Strategies that are particularly promising and suggestions for future research are given.
C1 [Pennington, Robert C.] Univ Louisville, Dept Teaching & Learning, Coll Educ & Human Dev, Louisville, KY 40292 USA.
RP Pennington, RC (reprint author), Univ Louisville, Dept Teaching & Learning, Coll Educ & Human Dev, Louisville, KY 40292 USA.
EM robert.pennington@louisville.edu
CR Akmanoglu N, 2004, EDUC TRAIN DEV DISAB, V39, P326
Akmanoglu-Uludag N, 2005, EDUC TRAIN DEV DISAB, V40, P401
Anohina A, 2005, EDUC TECHNOL SOC, V8, P91
Anzalone ME, 2000, COMM LANG INTERVEN, V9, P143
Asaro K, 2009, INTERV SCH CLIN, V44, P268, DOI 10.1177/1053451208330895
Asaro-Saddler K, 2010, EXCEPT CHILDREN, V77, P107
Baker SK, 2009, EXCEPT CHILDREN, V75, P303
Basil C., 2003, CHILD LANG TEACH THE, V19, P27, DOI [10.1191/0265659003ct242oa, DOI 10.1191/0265659003CT242OA]
Bedrosian J, 2003, TOP LANG DISORD, V23, P305
Bellini S, 2007, EXCEPT CHILDREN, V73, P264
Blischak DM, 2001, FOCUS AUTISM OTHER D, V16, P170, DOI 10.1177/108835760101600305
Boone R., 1996, FOCUS AUTISM OTHER D, V11, P69
Church C., 2000, FOCUS AUTISM OTHER D, V15, P12, DOI DOI 10.1177/108835760001500102
Delano M. F., 2007, FOCUS AUTISM OTHER D, V22, P252, DOI DOI 10.1177/10883576070220040701
Delano ME, 2007, J APPL BEHAV ANAL, V40, P345, DOI 10.1901/jaba.2007.50-06
Gersten R, 2005, EXCEPT CHILDREN, V71, P149
GRAHAM S, 1991, LEARN DISABILITY Q, V14, P89, DOI 10.2307/1510517
Graham S, 2007, J EDUC PSYCHOL, V99, P445, DOI 10.1037/0022-0663.99.3.445
Horner RH, 2005, EXCEPT CHILDREN, V71, P165
Jansiewicz EM, 2006, J AUTISM DEV DISORD, V36, P613, DOI 10.1007/s10803-006-0109-y
Joseph LM, 2009, RES DEV DISABIL, V30, P1, DOI 10.1016/j.ridd.2008.01.001
Kinney EM, 2003, J POSIT BEHAV INTERV, V5, P22, DOI 10.1177/10983007030050010301
LESLIE AM, 1987, PSYCHOL REV, V94, P412, DOI 10.1037/0033-295X.94.4.412
Mason LH, 2010, BEHAV DISORDERS, V35, P140
Matson JL, 2009, RES DEV DISABIL, V30, P240, DOI 10.1016/j.ridd.2008.04.001
Mayer RE, 2003, EDUC PSYCHOL-US, V38, P43, DOI 10.1207/S15326985EP3801_6
McCutchen D., 2003, HDB WRITING RES, P115
Mercer C. D., 2010, TEACHING STUDENTS LE
Minshew N J, 1997, J Int Neuropsychol Soc, V3, P303
Moore D, 2000, INNOV EDUC TRAIN INT, V37, P218
Moore M, 2000, J AUTISM DEV DISORD, V30, P359, DOI 10.1023/A:1005535602064
Mostert MP, 2001, J AUTISM DEV DISORD, V31, P287, DOI 10.1023/A:1010795219886
Myles BS, 2003, EDUC TRAIN MENT RET, V38, P362
Pennington R., 2011, ASSIST TECHNOL, V7, P24, DOI DOI 10.1353/ETC.2012.0022
Rogers LA, 2008, J EDUC PSYCHOL, V100, P879, DOI 10.1037/0022-0663.100.4.879
ROUSSEAU MK, 1994, RES DEV DISABIL, V15, P19, DOI 10.1016/0891-4222(94)90036-1
Schlosser RW, 1998, J AUTISM DEV DISORD, V28, P309, DOI 10.1023/A:1026060619378
Schlosser RW, 2004, J SPEECH LANG HEAR R, V47, P848, DOI [10.1044/1092-4388(2004/063), 10.4044/1092-4388(2004/063)]
Shanahan T., 2006, HDB WRITING RES, P171
Singer BD, 2004, CHALLENGES LANG LITE, P559
Stromer R, 1996, J APPL BEHAV ANAL, V29, P25, DOI 10.1901/jaba.1996.29-25
Sugasawara H, 2007, BEHAV INTERVENT, V22, P263, DOI 10.1002/bin.248
Tien KC, 2008, EDUC TRAIN DEV DISAB, V43, P61
U. S. Department of Education, 2001, 23 US DEP ED
Yamamoto J, 1999, RES DEV DISABIL, V20, P355, DOI 10.1016/S0891-4222(99)00017-7
NR 45
TC 7
Z9 7
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1088-3576
J9 FOCUS AUTISM DEV DIS
JI Focus Autism Dev. Disabil.
PD SEP
PY 2012
VL 27
IS 3
BP 158
EP 167
DI 10.1177/1088357612451318
PG 10
WC Education, Special; Psychology, Developmental; Rehabilitation
SC Education & Educational Research; Psychology; Rehabilitation
GA 987WS
UT WOS:000307449200003
ER
PT J
AU Sciutto, M
Richwine, S
Mentrikoski, J
Niedzwiecki, K
AF Sciutto, Mark
Richwine, Sally
Mentrikoski, Janelle
Niedzwiecki, Kathryn
TI A Qualitative Analysis of the School Experiences of Students With
Asperger Syndrome
SO FOCUS ON AUTISM AND OTHER DEVELOPMENTAL DISABILITIES
LA English
DT Article
DE Asperger syndrome; qualitative methods; school experiences
ID OF-LIFE; AUTISM; CHILDREN; CHALLENGES; SPECTRUM
AB In this study, adults with Asperger syndrome (AS) and caregivers of children with AS provided firsthand accounts of school-related challenges and influential instructional practices. A total of 94 participants (59 parents, 27 adults with AS, and 8 unspecified) completed an online survey containing open-ended questions about their (or their children's) school-related experiences. Participants identified specific areas of need (e.g., bullying, misunderstood intentions) related to understanding children with AS. In addition, participants described teacher qualities and instructional practices (e.g., strategies for communicating that the child is an asset, methods of structuring the environment for success) that had a positive impact on their (or their children's) school experiences. Implications for teacher training and school-based interventions are highlighted.
C1 [Sciutto, Mark; Richwine, Sally] Muhlenberg Coll, Allentown, PA 18104 USA.
[Mentrikoski, Janelle] W Virginia Univ, Morgantown, WV 26506 USA.
[Niedzwiecki, Kathryn] Edmond Publ Sch Dist, Edmond, OK USA.
RP Sciutto, M (reprint author), Muhlenberg Coll, 2400 W Chew St, Allentown, PA 18104 USA.
EM sciutto@muhlenberg.edu
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
Attwood T., 2007, COMPLETE GUIDE ASPER
Billington T, 2006, DISABIL SOC, V21, P1, DOI 10.1080/09687590500373627
Braun V., 2006, QUALITATIVE RES PSYC, V3, P77, DOI DOI 10.1191/1478088706QP063OA
Brewin BJ, 2008, FOCUS AUTISM DEV DIS, V23, P242, DOI 10.1177/1088357608322997
Chamak B, 2008, PSYCHOTHER PSYCHOSOM, V77, P271, DOI 10.1159/000140086
Carrington S, 2001, AUTISM, V5, P37, DOI 10.1177/1362361301005001004
Church C., 2000, FOCUS AUTISM OTHER D, V15, P12, DOI DOI 10.1177/108835760001500102
Eisenmajer R, 1996, J AM ACAD CHILD PSY, V35, P1523, DOI 10.1097/00004583-199611000-00022
Griswold D. E., 2002, FOCUS AUTISM OTHER D, V17, P94, DOI 10.1177/10883576020170020401
Helps S, 1999, AUTISM, V3, P287, DOI 10.1177/1362361399003003006
Hinshaw S. P., 2007, MARK SHAME STIGMA ME
Humphrey N, 2008, AUTISM, V12, P23, DOI 10.1177/1362361307085267
Jennes-Coussens M, 2006, AUTISM, V10, P403, DOI 10.1177/1362361306064432
Kunce L, 2003, LEARNING AND BEHAVIOR PROBLEMS IN ASPERGER SYNDROME, P244
Lancia R., 2000, ASPERGER SYNDROME, P125
Mattila ML, 2007, J AM ACAD CHILD PSY, V46, P636, DOI 10.1097/chi.0b013e318033ff42
McGregor E, 2001, AUTISM, V5, P189
Mitchell C., 2008, ADULTS SPEAK OUT ASP, P19
Muller E, 2008, AUTISM, V12, P173, DOI 10.1177/1362361307086664
Parkinson G., 2006, J RES SPECIAL ED NEE, V6, P76, DOI 10.1111/j.1471-3802.2006.00062.x
Portway S. M., 2003, EARLY CHILD DEV CARE, V173, P435, DOI 10.1080/0300443032000079113
Portway SM, 2005, HEALTH RISK SOC, V7, P73, DOI 10.1080/09500830500042086
Prior M., 2003, LEARNING BEHAV PROBL
Klin A, 2003, CHILD ADOL PSYCH CL, V12, P1, DOI 10.1016/S1056-4993(02)00052-4
Winter-Messiers M., 2007, FOCUS AUTISM OTHER D, V22, P67, DOI 10.1177/10883576070220020701
NR 26
TC 6
Z9 6
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1088-3576
J9 FOCUS AUTISM DEV DIS
JI Focus Autism Dev. Disabil.
PD SEP
PY 2012
VL 27
IS 3
BP 177
EP 188
DI 10.1177/1088357612450511
PG 12
WC Education, Special; Psychology, Developmental; Rehabilitation
SC Education & Educational Research; Psychology; Rehabilitation
GA 987WS
UT WOS:000307449200005
ER
PT J
AU Smith, MD
Graveline, PJ
Smith, JB
AF Smith, Marcia Datlow
Graveline, Patrick J.
Smith, Jared Brian
TI Autism and Obstacles to Medical Diagnosis and Treatment: Two Case
Studies
SO FOCUS ON AUTISM AND OTHER DEVELOPMENTAL DISABILITIES
LA English
DT Article
DE autism; illness; misdiagnosis
ID CARDIOVASCULAR-DISEASE; PATIENT COMMUNICATION; SPECTRUM DISORDERS;
HEALTH-CARE; PEOPLE; BASE
AB Autism is a developmental disability that provides special challenges to families, schools, and adult support systems. An additional area that is affected by the symptoms of autism is medicine. The deficits associated with autism in the areas of communication and social skills, as well as the prevalence of challenging behavior can interfere with the diagnosis of illnesses and in some cases result in the provision of erroneous treatment. In this article, the authors present two case studies describing individuals with autism whose catastrophic illnesses were misdiagnosed due, at least partially, to their autism. Obstacles to medical diagnosis and treatment are discussed, and recommendations for future research are provided.
C1 [Smith, Marcia Datlow] Jane Salzano Ctr Autism, CSAAC, Montgomery Village, MD 20886 USA.
[Graveline, Patrick J.] Community Support Serv, Gaithersburg, MD USA.
RP Smith, MD (reprint author), Jane Salzano Ctr Autism, CSAAC, 8615 E Village Ave, Montgomery Village, MD 20886 USA.
EM marceesmith@verizon.net
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
Buie T., 2010, PEDIATRICS, V125, P1
Goldson E., 2007, GROWING AUTISM WORKI, P39
Johnson C. P., 2004, AUTISM SPECTRUM DISO, P85
Kilbourne AM, 2008, J GEN INTERN MED, V23, P1628, DOI 10.1007/s11606-008-0720-z
Lennox NG, 1997, J INTELL DISABIL RES, V41, P365, DOI 10.1111/j.1365-2788.1997.tb00723.x
Mouridsen SE, 2008, AUTISM, V12, P403, DOI 10.1177/1362361308091653
Nasrallah HA, 2006, SCHIZOPHR RES, V86, P15, DOI 10.1016/j.schres.2006.06.026
Newcomer JW, 2007, JAMA-J AM MED ASSOC, V298, P1794, DOI 10.1001/jama.298.15.1794
ONG LML, 1995, SOC SCI MED, V40, P903, DOI 10.1016/0277-9536(94)00155-M
Seltzer MM, 2003, J AUTISM DEV DISORD, V33, P565, DOI 10.1023/B:JADD.0000005995.02453.0b
Shavelle R M, 1998, J Insur Med, V30, P220
Stein D, 2001, J AUTISM DEV DISORD, V31, P355, DOI 10.1023/A:1010707622612
STEWART MA, 1995, CAN MED ASSOC J, V152, P1423
Tager-Flusberg H., 2005, HDB AUTISM PERVASIVE, P335
WILSON DN, 1990, BRIT MED J, V301, P1379
NR 16
TC 1
Z9 1
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1088-3576
J9 FOCUS AUTISM DEV DIS
JI Focus Autism Dev. Disabil.
PD SEP
PY 2012
VL 27
IS 3
BP 189
EP 195
DI 10.1177/1088357612450049
PG 7
WC Education, Special; Psychology, Developmental; Rehabilitation
SC Education & Educational Research; Psychology; Rehabilitation
GA 987WS
UT WOS:000307449200006
ER
PT J
AU Kiykim, E
Soyucen, E
Zeybek, ACA
Cansever, MS
Aydin, A
AF Kiykim, E.
Soyucen, E.
Zeybek, Aktuglu A. C.
Cansever, M. S.
Aydin, A.
TI ZINC/COPPER METABOLISM IN AUTISM
SO JOURNAL OF INHERITED METABOLIC DISEASE
LA English
DT Meeting Abstract
C1 [Kiykim, E.; Soyucen, E.; Zeybek, Aktuglu A. C.; Cansever, M. S.; Aydin, A.] Ist Uni, Div Ped Nutr & Met, Cerr Med F, Istanbul, Turkey.
NR 0
TC 0
Z9 0
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0141-8955
J9 J INHERIT METAB DIS
JI J. Inherit. Metab. Dis.
PD SEP
PY 2012
VL 35
SU 1
BP S139
EP S139
PG 1
WC Endocrinology & Metabolism; Genetics & Heredity
SC Endocrinology & Metabolism; Genetics & Heredity
GA 988TH
UT WOS:000307513100485
ER
PT J
AU Spilioti, MG
Trama, D
Michailidi, E
Spanou, S
Frysira, H
Haidopoulou, A
Metaxas, S
Asprangathou, D
Bondi, E
Tsalkidis, AJ
Kardaras, P
Wevers, R
Jakobs, C
Evangeliou, AE
Gibson, KM
AF Spilioti, M. G.
Trama, D.
Michailidi, E.
Spanou, S.
Frysira, H.
Haidopoulou, A.
Metaxas, S.
Asprangathou, D.
Bondi, E.
Tsalkidis, A. J.
Kardaras, P.
Wevers, R.
Jakobs, C.
Evangeliou, A. E.
Gibson, K. M.
TI INBORN ERRORS OF METABOLISM (IEM) AND ASSOCIATED METABOLIC DISTURBANCES
DETECTED IN A COHORT OF GREEK PATIENTS WITH AUTISM SPECTRUM DISORDER
(ASD)
SO JOURNAL OF INHERITED METABOLIC DISEASE
LA English
DT Meeting Abstract
C1 [Spilioti, M. G.] AHEPA Hosp, Dept Neurol 1, Thessaloniki, Greece.
[Trama, D.; Spanou, S.; Haidopoulou, A.; Asprangathou, D.; Evangeliou, A. E.] Papageorgiou Hosp, Dept Pediat, Thessaloniki, Greece.
[Michailidi, E.; Kardaras, P.] Hippokrateion Hosp, Dept Pediat 3, Thessaloniki, Greece.
[Frysira, H.] Agia Sophia Childrens Hosp, Athens, Greece.
[Metaxas, S.] Papageorgiou Hosp, HNO Dept, Thessaloniki, Greece.
[Bondi, E.] Papageorgiou Hosp, Dept Psychiat, Thessaloniki, Greece.
[Tsalkidis, A. J.] Univ Hosp Alexandroupolis, Alexandroupolis, Greece.
[Wevers, R.] Univ Nijmegen Hosp, NL-6500 HB Nijmegen, Netherlands.
[Jakobs, C.] Akad Univ Hosp Amsterdam, Amsterdam, Netherlands.
[Gibson, K. M.] Wash State Univ, Spokane, WA USA.
RI Wevers, Ron/H-8116-2014
OI Wevers, Ron/0000-0003-2278-9746
NR 0
TC 0
Z9 0
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0141-8955
J9 J INHERIT METAB DIS
JI J. Inherit. Metab. Dis.
PD SEP
PY 2012
VL 35
SU 1
BP S169
EP S169
PG 1
WC Endocrinology & Metabolism; Genetics & Heredity
SC Endocrinology & Metabolism; Genetics & Heredity
GA 988TH
UT WOS:000307513100593
ER
PT J
AU McClean, B
Grey, I
AF McClean, Brian
Grey, Ian
TI An evaluation of an intervention sequence outline in positive behaviour
support for people with autism and severe escape-motivated challenging
behaviour
SO JOURNAL OF INTELLECTUAL & DEVELOPMENTAL DISABILITY
LA English
DT Article
DE positive behaviour support; multi-element behaviour support; severe
challenging behaviour
ID CHILDREN; HEALTH
AB Background Positive behaviour support emphasises the impact of contextual variables to enhance participation, choice, and quality of life. This study evaluates a sequence for implementing changes to key contextual variables for 4 individuals. Interventions were maintained and data collection continued over a 3-year period.
Method Functional assessments were conducted with 4 individuals with exceptionally severe challenging behaviours. Interventions were based on the multi-element model of behavioural support (LaVigna & Willis, 2005a). Dependent variables were behavioural ratings of (1) frequency, (2) episodic severity, (3) episodic management difficulty, and measures of (4) mental health status, and (5) quality of life. The intervention sequence was low arousal environment, rapport building, predictability, functionally equivalent skills teaching, and differential reinforcement strategies.
Results Substantial reductions in target behaviours were observed, along with incremental improvement in mental health scores and quality-of-life scores.
Conclusion The study demonstrates the efficacy of positive behaviour support for people with exceptionally severe behaviour in individually designed services.
C1 [McClean, Brian] Bros Char Serv, Roscommon, Ireland.
[Grey, Ian] Trinity Coll Dublin, Sch Psychol, Dublin, Ireland.
RP McClean, B (reprint author), Bros Char Serv, Roscommon, Ireland.
EM bmcclean@indigo.ie
CR Carr E. G., 1994, COMMUNICATION BASED
Duncan B. L., 2010, HEART SOUL CHANGE
Field T, 2001, AUTISM, V5, P317, DOI 10.1177/1362361301005003008
Green VA, 2006, RES DEV DISABIL, V27, P70, DOI 10.1016/j.ridd.2004.12.002
HARRIS P, 1993, J INTELL DISABIL RES, V37, P221
Hofmann S. G., 2006, FOCUS AUTISM OTHER D, V21, P100, DOI DOI 10.1177/10883576060210020101
HORNER RH, 1990, J ASSOC PERS SEVERE, V15, P125
Johnston JM, 2009, STRATEGIES AND TACTICS OF BEHAVIORAL RESEARCH, THIRD EDITION, P1
Kincaid D, 2002, J POSIT BEHAV INTERV, V4, P109, DOI 10.1177/109830070200400206
Koegel L. K., 1996, POSITIVE BEHAV SUPPO
Koegel LK, 2000, J AUTISM DEV DISORD, V30, P383, DOI 10.1023/A:1005539220932
LaVigna G. W., 1994, PERIODIC SERVICE REV
LaVigna G. W., 2005, TIZARD LEARNING DISA, V10, P16, DOI [10.1108/13595474200500016, DOI 10.1108/13595474200500016]
LaVigna GW, 2005, J POSIT BEHAV INTERV, V7, P47, DOI 10.1177/10983007050070010501
McClean B, 2005, J INTELL DISABIL RES, V49, P340, DOI 10.1111/j.1365-2788.2005.00669.x
McClean Brian, 2007, J Intellect Disabil, V11, P281, DOI 10.1177/1744629507080791
McClean B, 2012, J INTELLECT DEV DIS, V37, P221, DOI 10.3109/13668250.2012.704981
McDonnell A. A., 2010, MANAGING AGGRESSIVE
McLaughlin DM, 2005, J POSIT BEHAV INTERV, V7, P68
O'Reilly M, 2005, J AUTISM DEV DISORD, V35, P305, DOI 10.1007/s10803-005-3294-1
Paclawskyj TR, 2000, RES DEV DISABIL, V21, P223, DOI 10.1016/S0891-4222(00)00036-6
Roy A, 2002, BRIT J PSYCHIAT, V180, P61, DOI 10.1192/bjp.180.1.61
SCHOPLER E, 1980, J AUTISM DEV DISORD, V10, P91, DOI 10.1007/BF02408436
Willis T.J., 1993, BEHAV ASSESSMENT REP
NR 24
TC 1
Z9 1
PU INFORMA HEALTHCARE
PI LONDON
PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND
SN 1366-8250
J9 J INTELLECT DEV DIS
JI J. Intellect. Dev. Dis.
PD SEP
PY 2012
VL 37
IS 3
BP 209
EP 220
DI 10.3109/13668250.2012.704982
PG 12
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA 986RC
UT WOS:000307360900004
PM 22873574
ER
PT J
AU Griffith, GM
Totsika, V
Nash, S
Jones, RSP
Hastings, RP
AF Griffith, Gemma M.
Totsika, Vasiliki
Nash, Susie
Jones, Robert S. P.
Hastings, Richard P.
TI "We are all there silently coping." The hidden experiences of parents of
adults with Asperger syndrome
SO JOURNAL OF INTELLECTUAL & DEVELOPMENTAL DISABILITY
LA English
DT Article
DE adults; Asperger syndrome; family; independence; support
ID INTERPRETATIVE PHENOMENOLOGICAL ANALYSIS; PERVASIVE DEVELOPMENTAL
DISORDER; AUTISM SPECTRUM DISORDER; INTELLECTUAL DISABILITIES;
YOUNG-PEOPLE; CHILD; PERCEPTIONS; ADOLESCENTS; MOTHERS; POPULATION
AB Background The experiences of older parents of adults with Asperger syndrome have not been explored in the research literature.
Method Four families who had middle-aged offspring with Asperger syndrome were interviewed (3 mothers and 1 couple), and the interviews were analysed using interpretative phenomenological analysis (IPA).
Results Six themes emerged from the analysis: (a) providers of "hidden" support, (b) role of advocate, (c) social isolation, (d) intrafamilial relationships, (e) support for parents, and (f) future concerns.
Conclusions The findings of this study offer insight into the experience of parents of adult sons with Asperger syndrome. Implications for future support interventions and research are suggested.
C1 [Griffith, Gemma M.] Bangor Univ, Sch Psychol, Bangor LL57 2AS, Gwynedd, Wales.
RP Griffith, GM (reprint author), Bangor Univ, Sch Psychol, Brigantia Bldg,Penrallt Rd, Bangor LL57 2AS, Gwynedd, Wales.
EM g.m.griffith@bangor.ac.uk
RI Hastings, Richard/D-9657-2013
OI Hastings, Richard/0000-0002-0495-8270
CR American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th
Attwood T., 2007, COMPLETE GUIDE ASPER
Bigby C ., 2000, MOVING WITHOUT PAREN
Brocki JM, 2006, PSYCHOL HEALTH, V21, P87, DOI 10.1080/14768320500230185
Carrington S, 2001, AUTISM, V5, P37, DOI 10.1177/1362361301005001004
EHLERS S, 1993, J CHILD PSYCHOL PSYC, V34, P1327, DOI 10.1111/j.1469-7610.1993.tb02094.x
Elliott R, 1999, BRIT J CLIN PSYCHOL, V38, P215, DOI 10.1348/014466599162782
Grant G, 1998, J INTELL DISABIL RES, V42, P58, DOI 10.1046/j.1365-2788.1998.00079.x
Grant G, 2007, CAN J AGING, V26, P15, DOI 10.3138/cja.26.suppl1.15
Griffith GM, 2012, AUTISM, V16, P532, DOI 10.1177/1362361311405223
Griffith GM, 2011, J GENET COUNS, V20, P165, DOI 10.1007/s10897-010-9339-4
Hendricks DR, 2009, FOCUS AUTISM DEV DIS, V24, P77, DOI 10.1177/1088357608329827
Hines M, 2012, AUTISM, V16, P15, DOI 10.1177/1362361311416678
Howard B, 2006, AUTISM, V10, P619, DOI 10.1177/1362361306068508
Hurlbutt K., 2002, FOCUS AUTISM OTHER D, V17, P103, DOI [10.1177/10883576020170020501, DOI 10.1177/10883576020170020501]
Hurlbutt K, 2004, FOCUS AUTISM OTHER D, V19, P215, DOI DOI 10.1177/10883576040190040301
Huws JC, 2008, J INTELLECT DEV DIS, V33, P99, DOI 10.1080/13668250802010394
Krauss MW, 2005, J INTELL DISABIL RES, V49, P111, DOI 10.1111/j.1365-2788.2004.00599.x
Lasser J., 2008, ED PSYCHOL PRACTICE, V24, P335, DOI [10.1080/02667360802488773, DOI 10.1080/02667360802488773]
Milliken P J, 2001, Health Care Women Int, V22, P149, DOI 10.1080/073993301300003135
Molloy H., 2004, ASPERGER SYNDROME AD
Mugno D, 2007, HEALTH QUAL LIFE OUT, V5, DOI 10.1186/1477-7525-5-22
Muller E, 2003, J VOCATIONAL REHABIL, V18, P163
Muller E, 2008, AUTISM, V12, P173, DOI 10.1177/1362361307086664
Orsmond GI, 2006, AM J MENT RETARD, V111, P121, DOI 10.1352/0895-8017(2006)111[121:MRQAAA]2.0.CO;2
Petalas MA, 2009, INT J DISABIL DEV ED, V56, P381, DOI 10.1080/10349120903306715
Plimley LA, 2007, BRIT J LEARN DISABIL, V35, P205, DOI DOI 10.1111/J.1468-3156.2007.00448.X
Pownall JD, 2011, AJIDD-AM J INTELLECT, V116, P205, DOI 10.1352/1944-7558-116.3.205
Punshon C, 2009, AUTISM, V13, P265, DOI 10.1177/1362361309103795
Reilly D, 2010, INTELLECT DEV DISAB, V48, P403, DOI 10.1352/1934-9556-48.6.403
Reilly DE, 2008, J APPL RES INTELLECT, V21, P546, DOI 10.1111/j.1468-3148.2008.00427.x
Schieve LA, 2007, PEDIATRICS, V119, pS114, DOI 10.1542/peds.2006-2089Q
Schuntermann P, 2002, HARVARD REV PSYCHIAT, V10, P16, DOI 10.1093/hrp/10.1.16
Seltzer MM, 2010, J AUTISM DEV DISORD, V40, P457, DOI 10.1007/s10803-009-0887-0
Shearn J, 1997, J INTELL DISABIL RES, V41, P285, DOI 10.1111/j.1365-2788.1997.tb00712.x
Smith J. A., 1999, QUALITATIVE HLTH PSY, P218
Smith JA, 2002, J HEALTH PSYCHOL, V7, P131, DOI 10.1177/1359105302007002398
Sturges JE, 2004, QUALITATIVE RES, V4, P107, DOI DOI 10.1177/1468794104041110
Todd S, 2003, J APPL RES INTELLECT, V16, P229, DOI 10.1046/j.1468-3148.2003.00163.x
Todd S, 2005, J INTELL DISABIL RES, V49, P389, DOI 10.1111/j.1365-2788.2005.00675.x
Tonge BJ, 2002, MED J AUSTRALIA, V176, P412
Totsika V, 2011, J CHILD PSYCHOL PSYC, V52, P91, DOI 10.1111/j.1469-7610.2010.02295.x
Willig C, 2001, INTRO QUALITATIVE RE
NR 43
TC 2
Z9 2
PU INFORMA HEALTHCARE
PI LONDON
PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND
SN 1366-8250
J9 J INTELLECT DEV DIS
JI J. Intellect. Dev. Dis.
PD SEP
PY 2012
VL 37
IS 3
BP 237
EP 247
DI 10.3109/13668250.2012.701729
PG 11
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA 986RC
UT WOS:000307360900007
PM 22852754
ER
PT J
AU Bagozzi, RP
Verbeke, WJMI
van den Berg, WE
Rietdijk, WJR
Dietvorst, RC
Worm, L
AF Bagozzi, Richard P.
Verbeke, Willem J. M. I.
van den Berg, Wouter E.
Rietdijk, Wim J. R.
Dietvorst, Roeland C.
Worm, Loek
TI Genetic and neurological foundations of customer orientation: field and
experimental evidence
SO JOURNAL OF THE ACADEMY OF MARKETING SCIENCE
LA English
DT Article
DE Knowledge brokering; Opportunity recognition; Genetics; Customer
orientation; Neuroscience; Biomarkers; Personal selling; Marketing
concept
ID MIRROR-NEURON SYSTEM; AUTISM SPECTRUM DISORDERS; HUMAN FUSIFORM GYRUS;
GENERAL-APPROACH; HUMAN EMPATHY; PERSPECTIVE; KNOWLEDGE; SALES; MIND;
SALESPEOPLE
AB We explore genetic and neurological bases for customer orientation (CO) and contrast them with sales orientation (SO). Study 1 is a field study that establishes that CO, but not SO, leads to greater opportunity recognition. Study 2 examines genetic bases for CO and finds that salespeople with CO are more likely to have the 7R variant of the DRD4 gene. This is consistent with basic research on dopamine receptor activity in the brain that underlies novelty seeking, the reward function, and risk taking. Study 3 examines the neural basis of CO and finds that salespeople with CO, but not SO, experience greater activation of their mirror neuron systems and neural processes associated with empathy. Managerial and research implications are discussed.
C1 [Bagozzi, Richard P.] Univ Michigan, Ross Sch Business, Ann Arbor, MI 48109 USA.
[Verbeke, Willem J. M. I.; van den Berg, Wouter E.; Rietdijk, Wim J. R.; Dietvorst, Roeland C.; Worm, Loek] Erasmus Univ, Dept Business Econ, Erasmus Sch Econ, NL-3000 DR Rotterdam, Netherlands.
RP Bagozzi, RP (reprint author), Univ Michigan, Ross Sch Business, 701 Tappan St, Ann Arbor, MI 48109 USA.
EM bagozzi@umich.edu; Verbeke@ese.eur.nl; Verbeke@ese.eur.nl;
Verbeke@ese.eur.nl; Verbeke@ese.eur.nl
CR Bagozzi RP, 1998, ORGAN RES METHODS, V1, P45, DOI 10.1177/109442819800100104
Bagozzi RP, 1994, STRUCT EQU MODELING, V1, P35, DOI 10.1080/10705519409539961
Baron RA, 2004, ENTREP THEORY PRACT, V28, P553, DOI 10.1111/j.1540-6520.2004.00064.x
Berns G., 2005, SATISFACTION SENSATI
Berridge KC, 1998, BRAIN RES REV, V28, P309, DOI 10.1016/S0165-0173(98)00019-8
Blake R. R., 1970, GRID SALES EXCELLENC
Bonney L., 2009, EUR J MARKETING, V43, P1032
Carr L, 2003, P NATL ACAD SCI USA, V100, P5497, DOI 10.1073/pnas.0935845100
Cavanna AE, 2006, BRAIN, V129, P564, DOI 10.1093/brain/awl004
Cheng Y, 2009, NEUROSCIENCE, V158, P713, DOI 10.1016/j.neuroscience.2008.10.026
Cloninger R. C, 2004, FEELING GOOD SCI WEL
Congdon E, 2008, AM J MED GENET B, V147B, P27, DOI 10.1002/ajmg.b.30557
Cross R, 2004, ORGAN SCI, V15, P446, DOI 10.1287/orsc.1040.0075
Dapretto M, 2006, NAT NEUROSCI, V9, P28, DOI 10.1038/nn1611
Davis M. H., 1994, EMPATHY SOCIAL PSYCH
Dawes PL, 1998, J MARKETING, V62, P55, DOI 10.2307/1251743
Decety Jean, 2004, Behav Cogn Neurosci Rev, V3, P71, DOI 10.1177/1534582304267187
Decety J, 2006, THESCIENTIFICWORLDJO, V6, P1146, DOI 10.1100/tsw.2006.221
Decety J, 2007, NEUROSCIENTIST, V13, P580, DOI 10.1177/1073858407304654
Dietvorst RC, 2009, J MARKETING RES, V46, P653
Dreber A, 2009, EVOL HUM BEHAV, V30, P85, DOI 10.1016/j.evolhumbehav.2008.11.001
Eades K. M., 2004, NEW SOLUTION SELLING
Ebstein RP, 1996, NAT GENET, V12, P78, DOI 10.1038/ng0196-78
Edmondson AC, 2002, ORGAN SCI, V13, P128, DOI 10.1287/orsc.13.2.128.530
Edmonson A. C., 2003, BLACKWELL HDB ORGANI, P185
Eisenberg D. T. A., 2007, BEHAV BRAIN FUNCTION, V3
Eisenberg N, 2000, ANNU REV PSYCHOL, V51, P665, DOI 10.1146/annurev.psych.51.1.665
Ernst H, 2010, J MARKETING, V74, P80
Franke GR, 2006, J MARKETING RES, V43, P693, DOI 10.1509/jmkr.43.4.693
Gallese V, 2003, PHILOS T R SOC B, V358, P517, DOI 10.1098/rstb.2002.1234
Gregoire DA, 2010, ORGAN SCI, V21, P413, DOI 10.1287/orsc.1090.0462
GUO SW, 1992, BIOMETRICS, V48, P361, DOI 10.2307/2532296
Hallowell E.M., 1994, DRIVEN DISTRACTION R
Hartmann T., 2004, EDISON GENE ADHD GIF
Heaphy ED, 2008, ACAD MANAGE REV, V33, P137
HOLYOAK KJ, 1985, PSYCHOL LEARN MOTIV, V19, P59
Homburg C, 2009, J MARKETING, V73, P64
Huettel S. A., 2008, FUNCTIONAL MAGNETIC, Vsecond
Iacoboni M, 2006, NAT REV NEUROSCI, V7, P942, DOI 10.1038/nrn2024
Iacoboni M, 2009, ANNU REV PSYCHOL, V60, P653, DOI 10.1146/annurev.psych.60.110707.163604
Johnson JL, 2004, J MARKETING, V68, P21, DOI 10.1509/jmkg.68.3.21.34765
KOHLI A, 1989, J MARKETING, V53, P50, DOI 10.2307/1251342
Kreek MJ, 2005, NAT NEUROSCI, V8, P1450, DOI 10.1038/nn1583
Lamm C, 2007, J COGNITIVE NEUROSCI, V19, P42, DOI 10.1162/jocn.2007.19.1.42
Leigh T., 2001, J PERSONAL SELLING S, V21, P217
Levitt T., 1986, MARKETING IMAGINATIO
Mayer David, 1964, HARVARD BUSINESS JUL, P119
McCarthy G, 1997, J COGNITIVE NEUROSCI, V9, P605, DOI 10.1162/jocn.1997.9.5.605
McClure SM, 2004, SCIENCE, V306, P503, DOI 10.1126/science.1100907
Mercier H, 2011, BEHAV BRAIN SCI, V34, P57, DOI 10.1017/S0140525X10000968
Munafo MR, 2008, BIOL PSYCHIAT, V63, P197, DOI 10.1016/j.biopsych.2007.04.006
Nachev P, 2008, NAT REV NEUROSCI, V9, P856, DOI 10.1038/nrn2478
Nicolaou N, 2009, J BUS VENTURING, V24, P1, DOI 10.1016/j.jbusvent.2007.11.003
Nicolaou N, 2008, STRATEG ENTREP J, V2, P7, DOI 10.1002/sej.37
Oberman LM, 2007, PSYCHOL BULL, V133, P310, DOI 10.1037/0033-2909.133.2.310
Periatt Jeffery A., 2004, J PERSONAL SELLING S, V24, P49
Pettijohn CE, 2002, PSYCHOL MARKET, V19, P743, DOI 10.1002/mar.10033
Richardson L, 1994, STOP TELLING START S
Rodan S, 2004, STRATEGIC MANAGE J, V25, P541, DOI 10.1002/smj.398
SAXE R, 1982, J MARKETING RES, V19, P343, DOI 10.2307/3151568
Singer T, 2005, AM ECON REV, V95, P340, DOI 10.1257/000282805774670103
Skuse DH, 2009, TRENDS COGN SCI, V13, P27, DOI 10.1016/j.tics.2008.09.007
Stock RM, 2005, J ACAD MARKET SCI, V33, P536, DOI 10.1177/0092070305276868
Tanner RJ, 2008, J CONSUM RES, V34, P754, DOI 10.1086/522322
Thomas R. W., 2001, J PERSONAL SELLING S, V21, P63
van der Gaag C, 2007, SOC NEUROSCI, V2, P179, DOI 10.1080/17470910701376878
Vargo SL, 2004, J MARKETING, V68, P1, DOI 10.1509/jmkg.68.1.1.24036
Verbeke W, 2011, J ACAD MARKET SCI, V39, P407, DOI 10.1007/s11747-010-0211-8
Vogeley K, 2001, NEUROIMAGE, V14, P170, DOI 10.1006/nimg.2001.0789
Vogeley K, 2004, J COGNITIVE NEUROSCI, V16, P817, DOI 10.1162/089892904970799
Weitz BA, 1999, J ACAD MARKET SCI, V27, P241, DOI 10.1177/0092070399272008
Wheng SJ, 2009, THESIS U MICHIGAN
Wicker B, 2003, NEURON, V40, P655, DOI 10.1016/S0896-6273(03)00679-2
Wojciulik E, 1998, J NEUROPHYSIOL, V79, P1574
Zuckerman M., 1994, BEHAV EXPRESSIONS BI
NR 75
TC 10
Z9 10
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0092-0703
J9 J ACAD MARKET SCI
JI J. Acad. Mark. Sci.
PD SEP
PY 2012
VL 40
IS 5
BP 639
EP 658
DI 10.1007/s11747-011-0271-4
PG 20
WC Business
SC Business & Economics
GA 979EH
UT WOS:000306797400002
ER
PT J
AU Anckarsater, H
Hofvander, B
Billstedt, E
Gillberg, IC
Gillberg, C
Wentz, E
Rastam, M
AF Anckarsater, H.
Hofvander, B.
Billstedt, E.
Gillberg, I. C.
Gillberg, C.
Wentz, E.
Rastam, M.
TI The sociocommunicative deficit subgroup in anorexia nervosa: autism
spectrum disorders and neurocognition in a community-based, longitudinal
study
SO PSYCHOLOGICAL MEDICINE
LA English
DT Article
DE Anorexia nervosa; autism spectrum disorder; cognition; personality;
social interaction
ID NEUROPSYCHIATRIC DISORDERS; PERSONALITY-DISORDERS; DIAGNOSTIC INTERVIEW;
EMOTIONAL AWARENESS; FUNCTIONING AUTISM; NORMATIVE DATA; ONSET;
TEMPERAMENT; CHILDHOOD; CHARACTER
AB Background. A subgroup of persons with anorexia nervosa (AN) have been proposed to have sociocommunicative problems corresponding to autism spectrum disorders [ASDs, i.e. DSM-IV pervasive developmental disorders (PDDs): autistic disorder, Asperger's disorder, PDD not otherwise specified (NOS)]. Here, clinical problems, personality traits, cognitive test results and outcome are compared across 16 subjects (32%) with teenage-onset AN who meet or have met ASD criteria (AN + ASD), 34 ASD-negative AN subjects and matched controls from a longitudinal Swedish study including four waves of independent assessments from the teens to the early thirties.
Method. The fourth wave included the Structured Clinical Interview for DSM-IV (SCID)-I and the SCID-II (cluster C, i.e. 'anxious' PDs) interviews, the Asperger Syndrome Diagnostic Interview, self-assessments by the Autism Spectrum Quotient and the Temperament and Character Inventory, neurocognitive tests by subscales from the Wechsler scales, continuous performance tests, Tower of London, and Happe's cartoons.
Results. The ASD assessments had substantial inter-rater reliability over time (Cohen's kappa between 0.70 and 0.80 with previous assessments), even if only six subjects had been assigned a diagnosis of an ASD in all four waves of the study, including retrospective assessments of pre-AN neurodevelopmental problems. The AN + ASD group had the highest prevalence of personality disorders and the lowest Morgan-Russell scores. The non-ASD AN group also differed significantly from controls on personality traits related to poor interpersonal functioning and on neurocognitive tests.
Conclusions. A subgroup of subjects with AN meet criteria for ASDs. They may represent the extreme of neurocognitive and personality problems to be found more generally in AN.
C1 [Anckarsater, H.; Billstedt, E.; Gillberg, I. C.; Gillberg, C.; Wentz, E.; Rastam, M.] Univ Gothenburg, Sahlgrenska Acad, Inst Neurosci & Physiol, Gothenburg, Sweden.
[Anckarsater, H.; Hofvander, B.] Lund Univ, Dept Clin Sci, Malmo, Sweden.
[Wentz, E.] Swedish Inst Hlth Sci, Vardal Inst, Lund, Sweden.
[Rastam, M.] Lund Univ, Dept Clin Sci, Lund, Sweden.
RP Anckarsater, H (reprint author), Lillhagspk 3, S-42250 Hisings Backa, Sweden.
EM henrik.anckarsater@neuro.gu.se
FU Swedish Research Council [K2006-21X-20048-01-2]; government grants under
the ALF agreement; Knut and Alice Wallenberg's Foundation;
SoderstromKonigska Nursing Home Foundation; Swedish Medical Society;
Goteborg Freemasons
FX This work was supported by the Swedish Research Council
(K2006-21X-20048-01-2), government grants under the ALF agreement, Knut
and Alice Wallenberg's Foundation, the SoderstromKonigska Nursing Home
Foundation, the Swedish Medical Society, and the Goteborg Freemasons.
CR American Psychiatric Association (APA), 1994, DIAGN STAT MAN MENT, V4th
Anckarsater H, 2006, AM J PSYCHIAT, V163, P1239, DOI 10.1176/appi.ajp.163.7.1239
Baron-Cohen S, 2001, J AUTISM DEV DISORD, V31, P5, DOI 10.1023/A:1005653411471
Bejerot S, 2001, NORD J PSYCHIAT, V55, P169
Brandstrom S, 1998, COMPR PSYCHIAT, V39, P122, DOI 10.1016/S0010-440X(98)90070-0
Briskman J, 2001, J CHILD PSYCHOL PSYC, V42, P309, DOI 10.1111/1469-7610.00724
Chasson GS, 2011, CLIN PSYCHOL REV, V31, P653, DOI 10.1016/j.cpr.2011.02.006
CLONINGER CR, 1993, ARCH GEN PSYCHIAT, V50, P975
Constantino JN, 2003, ARCH GEN PSYCHIAT, V60, P524, DOI 10.1001/archpsyc.60.5.524
First M.B., 1997, STRUCTURED CLIN INTE
First Michael B, 1997, USERS GUIDE STRUCTUR
Gallagher HL, 2000, NEUROPSYCHOLOGIA, V38, P11, DOI 10.1016/S0028-3932(99)00053-6
Gillberg C, 2001, AUTISM, V5, P57, DOI 10.1177/1362361301005001006
GILLBERG IC, 1995, COMPR PSYCHIAT, V36, P61, DOI 10.1016/0010-440X(95)90100-A
GILLBERG IC, 2009, J CLIN EXP NEUROPSYC, V32, P358
GREENBERG LM, 1993, J CHILD PSYCHOL PSYC, V34, P1019, DOI 10.1111/j.1469-7610.1993.tb01105.x
Hofvander B, 2009, BMC PSYCHIATRY, V9, DOI 10.1186/1471-244X-9-35
Hollander E, 2009, PSYCHIAT RES, V170, P3, DOI 10.1016/j.psychres.2008.07.015
Kucharska-Pietura K, 2004, INT J EAT DISORDER, V35, P42, DOI 10.1002/eat.10219
LECOUTEUR A, 1989, J AUTISM DEV DISORD, V19, P363
Lichtenstein P, 2010, AM J PSYCHIAT, V167, P1357, DOI 10.1176/appi.ajp.2010.10020223
Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
Lundstrom S, 2011, PSYCHOL MED, V41, P2423, DOI 10.1017/S0033291711000377
Nilsson EW, 1999, J AM ACAD CHILD PSY, V38, P1389, DOI 10.1097/00004583-199911000-00013
Nilsson EW, 1998, COMPR PSYCHIAT, V39, P392, DOI 10.1016/S0010-440X(98)90053-0
Oldershaw A, 2010, PSYCHOSOM MED, V72, P73, DOI 10.1097/PSY.0b013e3181c6c7ca
Owen MJ, 2011, BRIT J PSYCHIAT, V198, P173, DOI 10.1192/bjp.bp.110.084384
RASTAM M, 1992, J AM ACAD CHILD PSY, V31, P819, DOI 10.1097/00004583-199209000-00007
Rastam M, 2003, EUR CHILD ADOLESC S1, V12, P178
RASTAM M, 1989, BRIT J PSYCHIAT, V155, P642
Rastam M, 1997, ACTA PSYCHIAT SCAND, V95, P385, DOI 10.1111/j.1600-0447.1997.tb09650.x
Rastam M, 2008, CLIN NEUROPSYCHIATRY, V5, P31
RATNASURIYA RH, 1991, BRIT J PSYCHIAT, V158, P495, DOI 10.1192/bjp.158.4.495
Russell TA, 2009, PSYCHIAT RES, V168, P181, DOI 10.1016/j.psychres.2008.10.028
Ryden E, 2008, CLIN NEUROPSYCHIATRY, V5, P13
SHALLICE T, 1982, PHILOS T ROY SOC B, V298, P199, DOI 10.1098/rstb.1982.0082
Silani G, 2008, SOC NEUROSCI, V3, P97, DOI 10.1080/17470910701577020
Siponmaa L, 2001, J AM ACAD PSYCHIATRY, V29, P420
Stahlberg O, 2004, J NEURAL TRANSM, V111, P891, DOI 10.1007/s00702-004-0115-1
TAYLOR GJ, 1993, PSYCHOTHER PSYCHOSOM, V60, P211
Torgersen S, 2001, ARCH GEN PSYCHIAT, V58, P590, DOI 10.1001/archpsyc.58.6.590
USTUN TB, 1995, EPIDEMIOL REV, V17, P210
Wechsler D, 1997, WECHSLER ADULT INTEL, V3rd
Wentz E, 2009, BRIT J PSYCHIAT, V194, P168, DOI 10.1192/bjp.bp.107.048686
Wentz E, 2005, EUR CHILD ADOLES PSY, V14, P431, DOI 10.1007/s00787-005-0494-3
Wing L, 2002, J CHILD PSYCHOL PSYC, V43, P307, DOI 10.1111/1469-7610.00023
Wolff S, 2004, EUR CHILD ADOLES PSY, V13, P201, DOI 10.1007/s00787-004-0363-5
Zucker NL, 2007, PSYCHOL BULL, V133, P976, DOI 10.1037/0033-2909.133.6.976
NR 48
TC 13
Z9 13
PU CAMBRIDGE UNIV PRESS
PI NEW YORK
PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA
SN 0033-2917
J9 PSYCHOL MED
JI Psychol. Med.
PD SEP
PY 2012
VL 42
IS 9
BP 1957
EP 1967
DI 10.1017/S0033291711002881
PG 11
WC Psychology, Clinical; Psychiatry; Psychology
SC Psychology; Psychiatry
GA 984LE
UT WOS:000307190400017
PM 22186945
ER
PT J
AU Young, A
AF Young, Allan
TI The Social Brain and the Myth of Empathy
SO SCIENCE IN CONTEXT
LA English
DT Article
ID MIRROR-NEURON SYSTEM; SHARED MANIFOLD HYPOTHESIS; MENTAL TIME-TRAVEL;
ALTRUISTIC PUNISHMENT; ASPERGER-SYNDROME; SEX-DIFFERENCES; TELL US;
EVOLUTION; AUTISM; MIND
AB Neuroscience research has created multiple versions of the human brain. The "social brain" is one version and it is the subject of this paper. Most image-based research in the field of social neuroscience is task-driven: the brain is asked to respond to a cognitive (perceptual) stimulus. The tasks are derived from theories, operational models, and back-stories now circulating in social neuroscience. The social brain comes with a distinctive back-story, an evolutionary history organized around three, interconnected themes: mind-reading, empathy, and the emergence of self-consciousness. This paper focuses on how empathy has been incorporated into the social brain and redefined via parallel research streams, employing a shared, imaging technology. The concluding section describes how these developments can be understood as signaling the emergence of a new version of human nature and the unconscious. My argument is not that empathy in the social brain is a myth, but rather that it is served by a myth consonant with the canons of science.
C1 McGill Univ, Montreal, PQ H3A 2T5, Canada.
RP Young, A (reprint author), McGill Univ, Montreal, PQ H3A 2T5, Canada.
EM allan.young@mcgill.ca
FU Social Science and Humanities Research Council of Canada
FX This paper has been supported by a research grant provided by the Social
Science and Humanities Research Council of Canada.
CR Addis DR, 2007, NEUROPSYCHOLOGIA, V45, P1363, DOI 10.1016/j.neuropsychologia.2006.10.016
Bargh JA, 2008, PERSPECT PSYCHOL SCI, V3, P73, DOI 10.1111/j.1745-6916.2008.00064.x
Barkow J. H., 1992, ADAPTED MIND EVOLUTI
Baron-Cohen S, 2005, SCIENCE, V310, P819, DOI 10.1126/science.1115455
Baron-Cohen S, 2004, J AUTISM DEV DISORD, V34, P163, DOI 10.1023/B:JADD.0000022607.19833.00
Barton R. A., 1997, MACHIAVELLIAN INTELL, P240
Berntsen D, 2004, MEM COGNITION, V32, P789, DOI 10.3758/BF03195869
Blakeslee Sandra, 2006, NY TIMES 0829
Boden M., 2006, MIND MACHINE HIST CO, V2
Boyd R, 2003, P NATL ACAD SCI USA, V100, P3531, DOI 10.1073/pnas.0630443100
Boyer P., 2010, TRENDS COGN SCI, V12, P219
Brass M, 2007, CURR BIOL, V17, P2117, DOI 10.1016/j.cub.2007.11.057
Brooks D., 2011, SOCIAL ANIMAL HIDDEN
Brooks David, 2011, NEW YORKER, P2
BROTHERS L, 1989, AM J PSYCHIAT, V146, P10
Busby J, 2005, COGNITIVE DEV, V20, P362, DOI 10.1016/j.cogdev.2005.05.002
Byrne R. W., 1988, MACHIAVELLIAN INTELL
Carr L, 2003, P NATL ACAD SCI USA, V100, P5497, DOI 10.1073/pnas.0935845100
Corballis MC, 2009, EXP BRAIN RES, V192, P553, DOI 10.1007/s00221-008-1491-9
Craighero Laila, 2004, J CLIN NEUROPHYSIOL, V21, P57
Csibra G, 2007, ACTA PSYCHOL, V124, P60, DOI 10.1016/j.actpsy.2006.09.007
Custers R, 2010, SCIENCE, V329, P47, DOI 10.1126/science.1188595
Decety J, 2006, BRAIN RES, V1079, P4, DOI 10.1016/j.brainres.2005.12.115
de Quervain DJF, 2004, SCIENCE, V305, P1254, DOI 10.1126/science.1100735
de Vignemont F, 2006, TRENDS COGN SCI, V10, P435, DOI 10.1016/j.tics.2006.08.008
de Vignemont F, 2008, SOC NEUROSCI, V3, P421, DOI 10.1080/17470910802045109
DIPELLEGRINO G, 1992, EXP BRAIN RES, V91, P176
Dinstein I, 2008, CURR BIOL, V18, pR956, DOI 10.1016/j.cub.2008.09.007
Dinstein I, 2007, J NEUROPHYSIOL, V98, P1415, DOI 10.1152/jn.00238.2007
Dinstein I, 2008, CURR BIOL, V18, pR13, DOI 10.1016/j.cub.2007.11.004
Dunbar RIM, 2003, ANNU REV ANTHROPOL, V32, P163, DOI 10.1146/annurev.anthro.32.061002.093158
Eagle Morris, 2007, J AM PSYCHOANAL ASS, V55, P151
Englis Basil G., 1989, INTERPERSONAL RELATI, V56, P543
FADIGA L, 1995, J NEUROPHYSIOL, V73, P2608
Fehr E, 2007, TRENDS COGN SCI, V11, P419, DOI 10.1016/j.tics.2007.09.002
Fliessbach K, 2007, SCIENCE, V318, P1305, DOI 10.1126/science.1145876
Fodor J. A., 2000, MIND DOESNT WORK WAY
Fodor J.A., 1983, MODULARITY MIND ESSA
Fogassi L, 2005, SCIENCE, V308, P662, DOI 10.1126/science.1106138
Friston KJ, 2002, ANNU REV NEUROSCI, V25, P221, DOI 10.1146/annurev.neuro.25.112701.142846
Gallese V, 2003, PSYCHOPATHOLOGY, V36, P171, DOI 10.1159/000072786
Gallese V, 1998, TRENDS COGN SCI, V2, P493, DOI 10.1016/S1364-6613(98)01262-5
Gallese V, 2004, TRENDS COGN SCI, V8, P396, DOI 10.1016/j.tics.2004.07.002
Gallese V, 2003, PHILOS T ROY SOC B, V358, P1231, DOI 10.1098/rstb.2003.1315
Gallese V, 2001, J CONSCIOUSNESS STUD, V8, P33
Gallese Vittorio, 2002, SEDIMENATRY ENV PROC, V297, P846
Gergely G, 2002, NATURE, V415, P755
Hadjikhani N, 2006, CEREB CORTEX, V16, P1276, DOI 10.1093/cercor/bh069
HAMILTON WD, 1964, J THEOR BIOL, V7, P1, DOI 10.1016/0022-5193(64)90038-4
Hassin R.R., 2005, NEW UNCONSCIOUS
Heyes C, 2010, NEUROIMAGE, V51, P789, DOI 10.1016/j.neuroimage.2010.02.034
Hickok G, 2009, J COGNITIVE NEUROSCI, V21, P1229, DOI 10.1162/jocn.2009.21189
Hrdy S. B., 2009, MOTHERS OTHERS EVOLU
Iacoboni M, 2006, NAT REV NEUROSCI, V7, P942, DOI 10.1038/nrn2024
Iacoboni M, 2009, ANNU REV PSYCHOL, V60, P653, DOI 10.1146/annurev.psych.60.110707.163604
Iacoboni M, 2005, PLOS BIOL, V3, P529, DOI 10.1371/journal.pbio.0030079
Iacoboni Marco, 2008, MIRRORING PEOPLE NEW
Jackson PL, 2005, NEUROIMAGE, V24, P771, DOI 10.1016/j.neuroimage.2004.09.006
Jacob P, 2008, MIND LANG, V23, P190, DOI 10.1111/j.1468-0017.2007.00337.x
Jacob P, 2005, TRENDS COGN SCI, V9, P21, DOI 10.1016/j.tics.2004.11.003
James W, 1890, PRINCIPLES PSYCHOL
JEANNEROD M, 1994, BEHAV BRAIN SCI, V17, P187
Jones EG, 2008, BRAIN, V131, P2227, DOI 10.1093/brain/awn158
Keysers C, 2010, CURR BIOL, V20, pR353, DOI 10.1016/j.cub.2010.03.013
Keysers C, 2010, NAT REV NEUROSCI, V11, P417, DOI 10.1038/nrn2833
Kilner JM, 2008, CURR BIOL, V18, pR32, DOI 10.1016/j.cub.2007.11.008
Knoch D, 2006, SCIENCE, V314, P829, DOI 10.1126/science.1129156
Kohler E, 2002, SCIENCE, V297, P846, DOI 10.1126/science.1070311
Kosik KS, 2003, NAT REV NEUROSCI, V4, P234, DOI 10.1038/nrn1053
Kosslyn SM, 2005, COGN NEUROPSYCHOL, V22, P333, DOI 10.1080/02643290442000130
Lawson J, 2004, J AUTISM DEV DISORD, V34, P301, DOI 10.1023/B:JADD.0000029552.42724.1b
Lerner Paul, 2003, HYSTERICAL MEN WAR P
LIBET B, 1983, BRAIN, V106, P623, DOI 10.1093/brain/106.3.623
LIBET B, 1985, BEHAV BRAIN SCI, V8, P529
Lindner I, 2010, PSYCHOL SCI, V21, P1291, DOI 10.1177/0956797610379860
Maynard Smith J., 2001, EVOLUTION, V55, P1496
Mukamel R., 2010, CURR BIOL, V20, P1
Nowak MA, 2005, NATURE, V437, P1291, DOI 10.1038/nature04131
Nummenmaa L, 2008, NEUROIMAGE, V43, P571, DOI 10.1016/j.neuroimage.2008.08.014
Oberman LM, 2005, COGNITIVE BRAIN RES, V24, P190, DOI 10.1016/j.cogbrainres.2005.01.014
Okuda J, 2003, NEUROIMAGE, V19, P1369, DOI 10.1016/S1053-8119(03)00179-4
Rizzolatti G, 2004, ANNU REV NEUROSCI, V27, P169, DOI 10.1146/annurev.neuro.27.070203.144230
Rizzolatti G, 2010, EXP BRAIN RES, V200, P223, DOI 10.1007/s00221-009-2002-3
Rizzolatti G, 1998, TRENDS NEUROSCI, V21, P188, DOI 10.1016/S0166-2236(98)01260-0
Rizzolatti G, 2010, NAT REV NEUROSCI, V11, P264, DOI 10.1038/nrn2805
Rosas A, 2008, BIOL PHILOS, V23, P555, DOI 10.1007/s10539-007-9065-y
Ryle G., 1949, CONCEPT MIND
Schacter DL, 2007, NAT REV NEUROSCI, V8, P657, DOI 10.1038/nrn2213
Schwartz DL, 1999, COGNITIVE PSYCHOL, V38, P433, DOI 10.1006/cogp.1998.0702
Shamay-Tsoory SG, 2009, BIOL PSYCHIAT, V66, P864, DOI 10.1016/j.biopsych.2009.06.009
Shmuelof L, 2007, NEUROSCIENTIST, V13, P667, DOI 10.1177/1073858407302457
Singer T, 2006, NATURE, V439, P466, DOI 10.1038/nature04271
Singer T, 2006, NEUROSCI BIOBEHAV R, V30, P855, DOI 10.1016/j.neubiorev.2006.06.011
Singer T, 2004, SCIENCE, V303, P1157, DOI 10.1126/science.1093535
Smith DF, 2010, PERSPECT BIOL MED, V53, P321, DOI 10.1353/pbm.0.0165
SMITH JM, 1979, PROC R SOC SER B-BIO, V205, P475, DOI 10.1098/rspb.1979.0080
Spence SA, 2004, J ROY SOC MED, V97, P6, DOI 10.1258/jrsm.97.1.6
Spence SA, 2002, CURR OPIN PSYCHIATR, V15, P519, DOI 10.1097/00001504-200209000-00010
Strawson G., 2008, REAL MAT OTHER ESSAY
Suddendorf T, 2009, PHILOS T R SOC B, V364, P1317, DOI 10.1098/rstb.2008.0301
Takahashi H, 2009, SCIENCE, V323, P937, DOI 10.1126/science.1165604
Tambiah Stanley Jeyaraja, 1990, MAGIC SCI RELIG SCOP
Tettamanti M, 2005, J COGNITIVE NEUROSCI, V17, P273, DOI 10.1162/0898929053124965
TRIVERS RL, 1971, Q REV BIOL, V46, P35, DOI 10.1086/406755
Turella L, 2009, BRAIN LANG, V108, P10, DOI 10.1016/j.bandl.2007.11.002
van der Gaag C, 2007, SOC NEUROSCI, V2, P179, DOI 10.1080/17470910701376878
Veyne Paul, 1988, DID GREEKS BELIEVE T
Wegner DM, 2002, BRADFORD BOOKS, P1
Wheelwright S, 2006, BRAIN RES, V1079, P47, DOI 10.1016/j.brainres.2006.01.012
Wicker B, 2003, NEURON, V40, P655, DOI 10.1016/S0896-6273(03)00679-2
Williams JHG, 2001, NEUROSCI BIOBEHAV R, V25, P287, DOI 10.1016/S0149-7634(01)00014-8
Young A., 1995, HARMONY ILLUSIONS IN
Young A, 2004, POSTTRAUMATIC STRESS, P127, DOI 10.1002/9780470713570.ch7
Young A., 2002, EVOL PSYCHIATR, V67, P26
Young A, 2006, SCI CONTEXT, V19, P175, DOI 10.1017/S0269889705000815
NR 115
TC 6
Z9 6
PU CAMBRIDGE UNIV PRESS
PI NEW YORK
PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA
SN 0269-8897
J9 SCI CONTEXT
JI Sci. Context
PD SEP
PY 2012
VL 25
IS 3
BP 401
EP 424
DI 10.1017/S0269889712000129
PG 24
WC History & Philosophy Of Science
SC History & Philosophy of Science
GA 984MG
UT WOS:000307193200006
ER
PT J
AU Lajiness-O'Neill, R
AF Lajiness-O'Neill, R.
TI Severe Social Impairment Does Not Always Mean Autism Spectrum Disorder
(ASD): A Case of Suspected Fetal Alcohol Spectrum Disorder (FASD)
SO ARCHIVES OF CLINICAL NEUROPSYCHOLOGY
LA English
DT Meeting Abstract
NR 0
TC 0
Z9 0
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0887-6177
J9 ARCH CLIN NEUROPSYCH
JI Arch. Clin. Neuropsychol.
PD SEP
PY 2012
VL 27
IS 6
BP 576
EP 577
PG 2
WC Psychology, Clinical; Psychology
SC Psychology
GA 988NH
UT WOS:000307497300003
ER
PT J
AU Koch, C
Roid, G
AF Koch, C.
Roid, G.
TI A Non-verbal Stroop Task Assessment of Inhibition among Children with
Autism
SO ARCHIVES OF CLINICAL NEUROPSYCHOLOGY
LA English
DT Meeting Abstract
NR 0
TC 0
Z9 0
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0887-6177
J9 ARCH CLIN NEUROPSYCH
JI Arch. Clin. Neuropsychol.
PD SEP
PY 2012
VL 27
IS 6
BP 592
EP 593
PG 2
WC Psychology, Clinical; Psychology
SC Psychology
GA 988NH
UT WOS:000307497300042
ER
PT J
AU Patrick, K
Hurewitz, F
Chute, D
Booth, A
AF Patrick, K.
Hurewitz, F.
Chute, D.
Booth, A.
TI Peabody Picture Vocabulary Test (PPVT) and Autism Diagnostic Observation
Schedule (ADOS) as Predictors of Word-Learning Abilities of Children
with Autism
SO ARCHIVES OF CLINICAL NEUROPSYCHOLOGY
LA English
DT Meeting Abstract
NR 0
TC 0
Z9 0
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0887-6177
J9 ARCH CLIN NEUROPSYCH
JI Arch. Clin. Neuropsychol.
PD SEP
PY 2012
VL 27
IS 6
BP 592
EP 592
PG 1
WC Psychology, Clinical; Psychology
SC Psychology
GA 988NH
UT WOS:000307497300041
ER
PT J
AU Stricker, S
Martner, S
Hansen, R
Ferraro, F
AF Stricker, S.
Martner, S.
Hansen, R.
Ferraro, F.
TI Prenatal, Perinatal, and Neonatal Complications in a Sample with Autism
Spectrum Disorders
SO ARCHIVES OF CLINICAL NEUROPSYCHOLOGY
LA English
DT Meeting Abstract
NR 0
TC 0
Z9 0
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0887-6177
J9 ARCH CLIN NEUROPSYCH
JI Arch. Clin. Neuropsychol.
PD SEP
PY 2012
VL 27
IS 6
BP 597
EP 597
PG 1
WC Psychology, Clinical; Psychology
SC Psychology
GA 988NH
UT WOS:000307497300054
ER
PT J
AU Weller, J
AF Weller, J.
TI Executive Functioning in Children with ADHD and Children with Autism
Spectrum Disorders
SO ARCHIVES OF CLINICAL NEUROPSYCHOLOGY
LA English
DT Meeting Abstract
NR 0
TC 0
Z9 0
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0887-6177
J9 ARCH CLIN NEUROPSYCH
JI Arch. Clin. Neuropsychol.
PD SEP
PY 2012
VL 27
IS 6
BP 672
EP 672
PG 1
WC Psychology, Clinical; Psychology
SC Psychology
GA 988NH
UT WOS:000307497300246
ER
PT J
AU Hubbard, AL
McNealy, K
Zeeland, AASV
Callan, DE
Bookheimer, SY
Dapretto, M
AF Hubbard, Amy L.
McNealy, Kristin
Zeeland, Ashley A. Scott-Van
Callan, Daniel E.
Bookheimer, Susan Y.
Dapretto, Mirella
TI Altered integration of speech and gesture in children with autism
spectrum disorders
SO BRAIN AND BEHAVIOR
LA English
DT Article
DE Autism spectrum disorders; fMRI; gesture; language; superior temporal
gyrus
AB The presence of gesture during speech has been shown to impact perception, comprehension, learning, and memory in normal adults and typically developing children. In neurotypical individuals, the impact of viewing co-speech gestures representing an object and/or action (i.e., iconic gesture) or speech rhythm (i.e., beat gesture) has also been observed at the neural level. Yet, despite growing evidence of delayed gesture development in children with autism spectrum disorders (ASD), few studies have examined how the brain processes multimodal communicative cues occurring during everyday communication in individuals with ASD. Here, we used a previously validated functional magnetic resonance imaging (fMRI) paradigm to examine the neural processing of co-speech beat gesture in children with ASD and matched controls. Consistent with prior observations in adults, typically developing children showed increased responses in right superior temporal gyrus and sulcus while listening to speech accompanied by beat gesture. Children with ASD, however, exhibited no significant modulatory effects in secondary auditory cortices for the presence of co-speech beat gesture. Rather, relative to their typically developing counterparts, children with ASD showed significantly greater activity in visual cortex while listening to speech accompanied by beat gesture. Importantly, the severity of their socio-communicative impairments correlated with activity in this region, such that the more impaired children demonstrated the greatest activity in visual areas while viewing co-speech beat gesture. These findings suggest that although the typically developing brain recognizes beat gesture as communicative and successfully integrates it with co-occurring speech, information from multiple sensory modalities is not effectively integrated during social communication in the autistic brain.
C1 [Hubbard, Amy L.; McNealy, Kristin; Zeeland, Ashley A. Scott-Van; Dapretto, Mirella] Univ Calif Los Angeles, Ahmanson Lovelace Brain Mapping Ctr, Los Angeles, CA USA.
[Hubbard, Amy L.] Carnegie Mellon Univ, Dept Modern Languages, Pittsburgh, PA 15213 USA.
[Hubbard, Amy L.; Callan, Daniel E.] Dept Computat Brain Imaging, Neural Informat Anal Labs, Kyoto, Japan.
[McNealy, Kristin; Zeeland, Ashley A. Scott-Van] Univ Calif Los Angeles, Neurosci Interdept Program, Los Angeles, CA USA.
[Bookheimer, Susan Y.; Dapretto, Mirella] Univ Calif Los Angeles, Dept Psychiat & Biobehav Sci, Los Angeles, CA USA.
RP Hubbard, AL (reprint author), Carnegie Mellon Univ, Dietrich Coll Human & Social Sci, Dept Modern Languages, Baker Hall 160, Pittsburgh, PA 15213 USA.
EM hubbarda@andrew.cmu.edu
FU NRSA predoctoral fellowship [F31 DC008762-01A1]; NICHD [P50 HD055784];
Foundation for Psychocultural Research-UCLA Center for Culture, Brain,
and Development; National Center for Research Resources (NCRR) [RR12169,
RR13642, RR00865]; National Institutes of Health (NIH); NIH training
grant [T32 DC000041]; Mellon Postdoctoral Fellowship in the Humanities;
National Institute of Information and Communications Technology
FX This study was, in part, supported by a NRSA predoctoral fellowship to
Amy Hubbard (F31 DC008762-01A1), NICHD (P50 HD055784), the Foundation
for Psychocultural Research-UCLA Center for Culture, Brain, and
Development; grants (RR12169, RR13642, and RR00865) from the National
Center for Research Resources (NCRR), a component of the National
Institutes of Health (NIH); further support for this research was
provided by a postdoctoral fellowship awarded to Amy Hubbard from NIH
training grant (T32 DC000041) to UCSD Center for Research in Language;
an A. W. Mellon Postdoctoral Fellowship in the Humanities to Amy
Hubbard; and the National Institute of Information and Communications
Technology.
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
Ashwin E, 2009, BIOL PSYCHIAT, V65, P17, DOI 10.1016/j.biopsych.2008.06.012
BALTAXE CAM, 1975, J SPEECH HEAR DISORD, V40, P439
BALTAXE CAM, 1977, J SPEECH HEAR DISORD, V42, P376
BALTAXE CAM, 1992, J AUTISM DEV DISORD, V22, P1, DOI 10.1007/BF01046399
Bertone A, 2005, BRAIN, V128, P2430, DOI 10.1093/brain/awh561
Breckinridge-Church R., 1986, COGNITION, V23, P43, DOI 10.1016/0010-0277(86)90053-3
Brett M., 2002, 8 INT C FUNCT MAPP H
Brett M, 2002, NAT REV NEUROSCI, V3, P243, DOI 10.1038/nrn756
Camaioni L, 2003, EUR PSYCHIAT, V18, P6, DOI 10.1016/S0924-9338(02)00013-5
Colgan SE, 2006, CHILD NEUROPSYCHOL, V12, P307, DOI 10.1080/09297040600701360
Constantino JN, 2003, J AUTISM DEV DISORD, V33, P427, DOI 10.1023/A:1025014929212
Constantino JN, 2000, J DEV BEHAV PEDIATR, V21, P2
Cook SW, 2008, COGNITION, V106, P1047, DOI 10.1016/j.cognition.2007.04.010
Friston KJ, 1999, NEUROIMAGE, V10, P385, DOI 10.1006/nimg.1999.0484
Goldin-Meadow S, 1999, J EDUC PSYCHOL, V91, P720, DOI 10.1037/0022-0663.91.4.720
Goldin-Meadow S, 2003, DEV PSYCHOL, V39, P509, DOI 10.1037/0012-1649.39.3.509
Goldin-Meadow S, 1999, DEVELOPMENTAL SCI, V2, P67, DOI 10.1111/1467-7687.00056
MORFORD M, 1992, J CHILD LANG, V19, P559
Goldin-Meadow S, 2005, TRENDS COGN SCI, V9, P234, DOI 10.1016/j.tics.2005.03.006
Holle H, 2008, NEUROIMAGE, V39, P2010, DOI 10.1016/j.neuroimage.2007.10.055
Hubbard AL, 2009, HUM BRAIN MAPP, V30, P1028, DOI 10.1002/hbm.20565
Iverson JM, 2005, PSYCHOL SCI, V16, P367, DOI 10.1111/j.0956-7976.2005.01542.x
Kelly SD, 2010, PSYCHOL SCI, V21, P260, DOI 10.1177/0956797609357327
Kleinhans NM, 2008, BRAIN, V131, P1000, DOI 10.1093/brain/awm334
Klin A, 2009, NATURE, V459, P257, DOI 10.1038/nature07868
Klin A, 2002, AM J PSYCHIAT, V159, P895, DOI 10.1176/appi.ajp.159.6.895
Koshino H, 2008, CEREB CORTEX, V18, P289, DOI 10.1093/cercor/bhm054
Kujala T, 2005, NEUROSCI LETT, V383, P260, DOI 10.1016/j.neulet.2005.04.048
LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
VENTER A, 1992, J CHILD PSYCHOL PSYC, V33, P489, DOI 10.1111/j.1469-7610.1992.tb00887.x
Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
Luyster RJ, 2008, J AUTISM DEV DISORD, V38, P1426, DOI 10.1007/s10803-007-0510-1
Mazziotta J, 2001, PHILOS T R SOC B, V356, P1293
McCann J, 2003, INT J LANG COMM DIS, V38, P325, DOI 10.1080/1368282031000154204
MCGURK H, 1976, NATURE, V264, P746, DOI 10.1038/264746a0
McNeill D., 2005, GESTURE AND THOUGHT
McNeill D., 1992, HAND AND MIND
Minshew NJ, 2007, ARCH NEUROL-CHICAGO, V64, P945, DOI 10.1001/archneur.64.7.945
Mitchell S, 2006, J DEV BEHAV PEDIATR, V27, pS69, DOI 10.1097/00004703-200604002-00004
Mizuno A, 2006, BRAIN RES, V1104, P160, DOI 10.1016/j.brainres.2006.05.064
Mongillo EA, 2008, J AUTISM DEV DISORD, V38, P1349, DOI 10.1007/s10803-007-0521-y
Oberman LM, 2007, PSYCHOL BULL, V133, P310, DOI 10.1037/0033-2909.133.2.310
Paul R., 1987, HDB AUTISM PERVASIVE, P61
PRONOVOST W, 1966, EXCEPT CHILDREN, V33, P19
Rutherford MD, 2002, J AUTISM DEV DISORD, V32, P189, DOI 10.1023/A:1015497629971
Shriberg LD, 2001, J SPEECH LANG HEAR R, V44, P1097, DOI 10.1044/1092-4388(2001/087)
Silverman LB, 2010, COGNITION, V115, P380, DOI 10.1016/j.cognition.2010.01.002
Singer MA, 2005, PSYCHOL SCI, V16, P85, DOI 10.1111/j.0956-7976.2005.00786.x
Sowden H, 2008, CLIN LINGUIST PHONET, V22, P804, DOI 10.1080/02699200801919745
Trillingsgaard A, 2005, EUR CHILD ADOLES PSY, V14, P65, DOI 10.1007/s00787-005-0433-3
Tzourio-Mazoyer N, 2002, NEUROIMAGE, V15, P273, DOI 10.1006/nimg.2001.0978
Vandenbroucke MWG, 2008, BRAIN, V131, P1013, DOI 10.1093/brain/awm321
Villalobos ME, 2005, NEUROIMAGE, V25, P916, DOI 10.1016/j.neuroimage.2004.12.022
Wang AT, 2006, BRAIN, V129, P932, DOI 10.1093/brain/awl032
Wechsler D, 1999, WECHSLER ABBREVIATED
Wechsler D, 1991, WECHSLER INTELLIGENC, V3rd
Wetherby AM, 2007, J AUTISM DEV DISORD, V37, P960, DOI 10.1007/s10803-006-0237-4
Whitehouse AJO, 2008, DEVELOPMENTAL SCI, V11, P516, DOI 10.1111/j.1467-7687.2008.00697.x
Willems RM, 2008, J COGNITIVE NEUROSCI, V20, P1235, DOI 10.1162/jocn.2008.20085
Willems RM, 2007, CEREB CORTEX, V17, P2322, DOI 10.1093/cercor/bhl141
Williams JHG, 2004, RES DEV DISABIL, V25, P559, DOI 10.1016/j.ridd.2004.01.008
zcaliskan S., 2005, COGNITION, V96, pB101
zyurek A., 2007, J COGNITIVE NEUROSCI, V19, P605
NR 64
TC 3
Z9 4
PU JOHN WILEY & SONS INC
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 2162-3279
J9 BRAIN BEHAV
JI Brain Behav.
PD SEP
PY 2012
VL 2
IS 5
BP 606
EP 619
DI 10.1002/brb3.81
PG 14
WC Behavioral Sciences; Neurosciences
SC Behavioral Sciences; Neurosciences & Neurology
GA V35UT
UT WOS:000209174200009
PM 23139906
ER
PT J
AU Fan, J
Bernardi, S
Van Dam, NT
Anagnostou, E
Gu, XS
Martin, L
Park, Y
Liu, X
Kolevzon, A
Soorya, L
Grodberg, D
Hollander, E
Hof, PR
AF Fan, Jin
Bernardi, Silvia
Van Dam, Nicholas T.
Anagnostou, Evdokia
Gu, Xiaosi
Martin, Laura
Park, Yunsoo
Liu, Xun
Kolevzon, Alexander
Soorya, Latha
Grodberg, David
Hollander, Eric
Hof, Patrick R.
TI Functional deficits of the attentional networks in autism
SO BRAIN AND BEHAVIOR
LA English
DT Article
DE Alerting; anterior cingulate cortex; attentional networks; autism;
executive control
AB Attentional dysfunction is among the most consistent observations of autism spectrum disorders (ASD). However, the neural nature of this deficit in ASD is still unclear. In this study, we aimed to identify the neurobehavioral correlates of attentional dysfunction in ASD. We used the Attention Network Test-Revised and functional magnetic resonance imaging to examine alerting, orienting, and executive control functions, as well as the neural substrates underlying these attentional functions in unmedicated, high-functioning adults with ASD (n = 12) and matched healthy controls (HC, n = 12). Compared with HC, individuals with ASD showed increased error rates in alerting and executive control, accompanied by lower activity in the mid-frontal gyrus and the caudate nucleus for alerting, and by the absence of significant functional activation in the anterior cingulate cortex (ACC) for executive control. In addition, greater behavioral deficiency in executive control in ASD was correlated with less functional activation of the ACC. These findings of behavioral and neural abnormalities in alerting and executive control of attention in ASD may suggest core attentional deficits, which require further investigation.
C1 [Fan, Jin; Van Dam, Nicholas T.] CUNY Queens Coll, Dept Psychol, Flushing, NY 11367 USA.
[Fan, Jin; Bernardi, Silvia; Van Dam, Nicholas T.; Anagnostou, Evdokia; Gu, Xiaosi; Martin, Laura; Park, Yunsoo; Liu, Xun; Kolevzon, Alexander; Soorya, Latha; Grodberg, David] Mt Sinai Sch Med, Dept Psychiat, New York, NY USA.
[Fan, Jin; Gu, Xiaosi; Hof, Patrick R.] Mt Sinai Sch Med, Fishberg Dept Neurosci, New York, NY USA.
[Fan, Jin; Gu, Xiaosi; Hof, Patrick R.] Mt Sinai Sch Med, Friedman Brain Inst, New York, NY USA.
[Fan, Jin; Bernardi, Silvia; Anagnostou, Evdokia; Kolevzon, Alexander; Soorya, Latha; Grodberg, David] Mt Sinai Sch Med, Seaver Autism Ctr Res & Treatment, New York, NY USA.
[Hollander, Eric] Albert Einstein Coll Med, New York, NY USA.
[Hollander, Eric] Montefiore Med Ctr, New York, NY USA.
RP Fan, J (reprint author), CUNY Queens Coll, Dept Psychol, 65-30 Kissena Blvd, Flushing, NY 11367 USA.
EM jin.fan@qc.cuny.edu
RI Gu, Xiaosi/A-7724-2010; Liu, Xun/C-2400-2009; Fan, Jin/A-6716-2009
OI Liu, Xun/0000-0003-1366-8926; Fan, Jin/0000-0001-9630-8330
FU National Center for Research Resources (NCRR) [M01 RR000071]; Seaver
Autism Center for Research and Treatment at Mount Sinai School of
Medicine; National Institutes of Health (NIH) [R21 MH083164]; James S.
McDonnell Foundation
FX This work was supported by National Center for Research Resources (NCRR)
Grant M01 RR000071. Its contents are solely the responsibility of the
authors and do not necessarily represent the official views of NCRR or
National Institute of Mental Health (NIMH). This work was also supported
in, part by, Seaver Autism Center for Research and Treatment at Mount
Sinai School of Medicine, by National Institutes of Health (NIH) grant
R21 MH083164 (to J. F.), and by the James S. McDonnell Foundation (to P.
R. H.).
CR Allen G, 2001, FRONT BIOSCI-LANDMRK, V6, pD105, DOI 10.2741/allen
Belmonte M. K., 2000, AUTISM, V4, P269, DOI DOI 10.1177/1362361300004003004
Bernardi S, 2011, BRAIN RES, V1380, P198, DOI 10.1016/j.brainres.2010.12.057
Botvinick MM, 2001, PSYCHOL REV, V108, P624, DOI 10.1037//0033-295X.108.3.624
BURACK JA, 1994, J ABNORM PSYCHOL, V103, P535, DOI 10.1037/0021-843X.103.3.535
Burack J. A., 1997, HDB AUTISM PERVASIVE, P226
Bush G, 2000, TRENDS COGN SCI, V4, P215, DOI 10.1016/S1364-6613(00)01483-2
CASEY BJ, 1993, J CLIN EXP NEUROPSYC, V15, P933, DOI 10.1080/01688639308402609
Clerkin SM, 2009, BIOL PSYCHIAT, V66, P307, DOI 10.1016/j.biopsych.2009.04.013
Corbetta M, 2008, NEURON, V58, P306, DOI 10.1016/j.neuron.2008.04.017
Corbetta M, 2002, NAT REV NEUROSCI, V3, P201, DOI 10.1038/nrn755
Courchesne E, 2001, NEUROLOGY, V57, P245
COURCHESNE E, 1993, AM J ROENTGENOL, V160, P387
COURCHESNE E, 1994, BEHAV NEUROSCI, V108, P848, DOI 10.1037//0735-7044.108.5.848
Courchesne E., 1994, ATYPICAL COGNITIVE D, P101
Dawson G, 1998, J AUTISM DEV DISORD, V28, P479, DOI 10.1023/A:1026043926488
Dichter GS, 2007, NEUROIMAGE, V35, P1219, DOI 10.1016/j.neuroimage.2006.12.038
Dosenbach NUF, 2008, TRENDS COGN SCI, V12, P99, DOI 10.1016/j.tics.2008.01.001
Fan J, 2005, NEUROIMAGE, V26, P471, DOI 10.1016/j.neuroimage.2005.02.004
Fan J, 2002, J COGNITIVE NEUROSCI, V14, P340, DOI 10.1162/089892902317361886
Fan J, 2003, NEUROIMAGE, V18, P42, DOI 10.1006/nimg.2002.1319
Fan J, 2011, NEUROIMAGE, V54, P2539, DOI 10.1016/j.neuroimage.2010.10.007
Fan J, 2007, J NEUROSCI, V27, P2272, DOI 10.1523/JNEUROSCI.3470-06.2007
Fan J, 2009, BRAIN COGNITION, V70, P209, DOI 10.1016/j.bandc.2009.02.002
FRITH CD, 1991, P ROY SOC B-BIOL SCI, V244, P241, DOI 10.1098/rspb.1991.0077
Garavan H, 2002, NEUROIMAGE, V17, P1820, DOI 10.1006/nimg.2002.1326
GARRETSON HB, 1990, J AUTISM DEV DISORD, V20, P101, DOI 10.1007/BF02206860
Greene DJ, 2011, NEUROIMAGE, V56, P354, DOI 10.1016/j.neuroimage.2011.02.031
Harris NS, 1999, COGNITIVE BRAIN RES, V8, P61, DOI 10.1016/S0926-6410(99)00006-3
Haznedar MM, 1997, AM J PSYCHIAT, V154, P1047
Kana RK, 2007, BIOL PSYCHIAT, V62, P198, DOI 10.1016/j.biopsych.2006.08.004
Landry R, 2004, J CHILD PSYCHOL PSYC, V45, P1115, DOI 10.1111/j.1469-7610.2004.00304.x
Lieberman MD, 2009, SOC COGN AFFECT NEUR, V4, P423, DOI 10.1093/scan/nsp052
LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
LOVAAS OI, 1971, J ABNORM PSYCHOL, V77, P211, DOI 10.1037/h0031015
LOVAAS OI, 1979, PSYCHOL BULL, V86, P1236, DOI 10.1037//0033-2909.86.6.1236
Matsumoto K, 2004, SCIENCE, V303, P969, DOI 10.1126/science.1094733
Miller GA, 2001, J ABNORM PSYCHOL, V110, P40, DOI 10.1037//0021-843X.110.1.40
OLDFIELD RC, 1971, NEUROPSYCHOLOGIA, V9, P97, DOI 10.1016/0028-3932(71)90067-4
OZONOFF S, 1994, DEV PSYCHOPATHOL, V6, P415, DOI 10.1017/S0954579400006027
Pascualvaca DM, 1998, J AUTISM DEV DISORD, V28, P467, DOI 10.1023/A:1026091809650
Posner M. I., 2008, TOPICS INTEGRATIVE N, P31, DOI 10.1017/CBO9780511541681.005
POSNER MI, 1984, J NEUROSCI, V4, P1863
Rinehart NJ, 2001, AUTISM, V5, P67, DOI 10.1177/1362361301005001007
ROSVOLD HE, 1956, J CONSULT PSYCHOL, V20, P343, DOI 10.1037/h0043220
Russell J, 1999, J AUTISM DEV DISORD, V29, P103, DOI 10.1023/A:1023084425406
Shafritz KM, 2008, BIOL PSYCHIAT, V63, P974, DOI 10.1016/j.biopsych.2007.06.028
SIEGEL BV, 1992, J NEUROPSYCH CLIN N, V4, P406
Solomon M, 2009, NEUROPSYCHOLOGIA, V47, P2515, DOI 10.1016/j.neuropsychologia.2009.04.019
Sparks BF, 2002, NEUROLOGY, V59, P184
Teder-Salejarvi WA, 2005, COGNITIVE BRAIN RES, V23, P221, DOI 10.1016/j.cogbrainres.2004.10.021
Thakkar KN, 2008, BRAIN, V131, P2464, DOI 10.1093/brain/awn099
TOWNSEND J, 1994, J COGNITIVE NEUROSCI, V6, P220, DOI 10.1162/jocn.1994.6.3.220
Townsend J, 1999, J NEUROSCI, V19, P5632
Townsend J, 1996, J Int Neuropsychol Soc, V2, P541
Townsend J, 1996, DEV PSYCHOPATHOL, V8, P563
Wainwright JA, 1996, J AUTISM DEV DISORD, V26, P423, DOI 10.1007/BF02172827
WAINWRIGHTSHARP JA, 1993, J AUTISM DEV DISORD, V23, P1, DOI 10.1007/BF01066415
Wechsler D, 1997, WECHSLER ADULT INTEL, V3rd
Welchew DE, 2005, BIOL PSYCHIAT, V57, P991, DOI 10.1016/j.biopsych.2005.01.028
NR 61
TC 11
Z9 11
PU JOHN WILEY & SONS INC
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 2162-3279
J9 BRAIN BEHAV
JI Brain Behav.
PD SEP
PY 2012
VL 2
IS 5
BP 647
EP 660
DI 10.1002/brb3.90
PG 14
WC Behavioral Sciences; Neurosciences
SC Behavioral Sciences; Neurosciences & Neurology
GA V35UT
UT WOS:000209174200013
PM 23139910
ER
PT J
AU Stein, LI
Polido, JC
Najera, SOL
Cermak, SA
AF Stein, Leah I.
Polido, Jose C.
Najera, Sandy Oliver Lopez
Cermak, Sharon A.
TI Oral Care Experiences and Challenges in Children with Autism Spectrum
Disorders
SO PEDIATRIC DENTISTRY
LA English
DT Article
DE HEALTH PROMOTION; ACCESS TO CARE; AUTISM SPECTRUM DISORDERS; DENTAL CARE
FOR DISABLED; OCCUPATIONAL THERAPY
AB Purpose: The purpose of this study was to investigate the differences between children with autism spectrum disorders (ASD) and their typically developing peers in relation to aspects of oral care. Methods: Participants included 396 parents of ASD children or typically developing 2- to 18-year-olds. Parents completed a 37-item questionnaire designed by authors to elicit information about oral core in the home and dental office. Descriptive, bivariate, and multivariate regression analyses were conducted to examine the association between diagnostic group and oral care variables. Results: Significantly more parents of ASD children than parents of typically developing children reported difficulty across almost all oral care variables explored, including oral care in the home, oral core at the dentist, and access to oral care. Following multivariate regression to control for possible confounders including age, gender, Hispanic status, and paternal education level all previously significant variables remained significant. Conclusion: This study indicates that children with autism spectrum disorders experience greater difficulties and barriers to care in both the home and dental office settings than their typically developing peers.
C1 [Stein, Leah I.; Cermak, Sharon A.] Univ So Calif, Herman Ostrow Sch Dent, Div Occupat Sci & Occupat Therapy, Los Angeles, CA 90089 USA.
[Polido, Jose C.] Childrens Hosp Los Angeles, Div Dent, Los Angeles, CA 90027 USA.
[Polido, Jose C.] Univ So Calif, Herman Ostrow Sch Dent, Los Angeles, CA USA.
[Najera, Sandy Oliver Lopez] Univ So Calif, Keck Sch Med, Div Biostat, Los Angeles, CA 90033 USA.
RP Stein, LI (reprint author), Univ So Calif, Herman Ostrow Sch Dent, Div Occupat Sci & Occupat Therapy, Los Angeles, CA 90089 USA.
EM lstein@usc.edu
CR AAPD, POL ETH RESP TREAT R
American Academy of Pediatric Dentistry, 2013, GUID PER EX PREV DEN
American Psychiatric Association, 2000, DIAGN STAT MAN MENT
[Anonymous], AUT SPECTR DIS DAT S
Brickhouse Tegwyn H, 2009, J Dent Child (Chic), V76, P188
Casamassimo P., 1996, BRIGHT FUTURES PRACT
Casamassimo Paul S, 2004, J Dent Educ, V68, P23
CDA ADA, ACCR STAND ADV ED PR
Commission on Dental Accreditation, ACCR STAND DENT ED P
Fahlvik-Planefeldt C, 2001, SWED DENT J, V25, P113
Friedlander AH, 2006, J AM DENT ASSOC, V137, P1517
Friedlander Arthur H, 2003, J Calif Dent Assoc, V31, P681
Glassman Paul, 2005, J Calif Dent Assoc, V33, P619
Glassman Paul, 2009, Spec Care Dentist, V29, P31, DOI 10.1111/j.1754-4505.2008.00060.x
Green Danielle, 2008, General Dentistry, V56, P167
Hulland S, 2000, Spec Care Dentist, V20, P131, DOI 10.1111/j.1754-4505.2000.tb01149.x
Klein U, 1999, Spec Care Dentist, V19, P200, DOI 10.1111/j.1754-4505.1999.tb01386.x
Kopycka-Kedzierawski DT, 2008, PEDIATR DENT, V30, P54
Loo CY, 2008, J AM DENT ASSOC, V139, P1518
Loo CY, 2009, INT J PAEDIATR DENT, V19, P390, DOI 10.1111/j.1365-263X.2009.01011.x
Lord C., 1999, AUTISM DIAGNOSTIC OB
Marshall J, 2008, PEDIATR DENT, V30, P400
Marshall J, 2010, PEDIATR DENT, V32, P69
Marshall J, 2007, PEDIATR DENT, V29, P369
National Institute of Dental and Craniofacial Research, PRACT OR CAR PEOPL A
Nelson LP, 2011, PEDIATR DENT, V33, P29
Owens PL, 2006, MENT RETARD DEV D R, V12, P28, DOI 10.1002/mrdd.20096
Rutter M., 2003, AUTISM DIAGNOSTIC IN
Souders Margaret C, 2002, Pediatr Nurs, V28, P555
U. S. Department of Health and Human Services, 2000, HLTH PEOPL 2010, V2nd
Williams KS, 2009, ACCESS, V23, P34
NR 31
TC 5
Z9 5
PU AMER ACAD PEDIATRIC DENTISTRY
PI CHICAGO
PA 211 E CHICAGO AVENUE SUITE 1036, CHICAGO, IL 60611-2616 USA
SN 0164-1263
EI 1942-5473
J9 PEDIATR DENT
JI Pediatr. Dent.
PD SEP-OCT
PY 2012
VL 34
IS 5
BP 387
EP 391
PG 5
WC Dentistry, Oral Surgery & Medicine; Pediatrics
SC Dentistry, Oral Surgery & Medicine; Pediatrics
GA V35FE
UT WOS:000209135200006
PM 23211914
ER
PT J
AU Ipser, JC
Syal, S
Bentley, J
Adnams, CM
Steyn, B
Stein, DJ
AF Ipser, Jonathan C.
Syal, Supriya
Bentley, Judy
Adnams, Colleen M.
Steyn, Bennie
Stein, Dan J.
TI 1H-MRS in autism spectrum disorders: a systematic meta-analysis
SO METABOLIC BRAIN DISEASE
LA English
DT Article
DE Autism spectrum disorders; Magnetic resonance imaging; Meta-analysis;
Asperger syndrome; NAA; Creatine
ID MAGNETIC-RESONANCE-SPECTROSCOPY; HIGH-FUNCTIONING AUTISM; TEMPORAL-LOBE
EPILEPSY; CEREBRAL-BLOOD-FLOW; N-ACETYL-ASPARTATE; ASPERGER-SYNDROME;
WHITE-MATTER; BRAIN-METABOLITES; CHILDHOOD AUTISM; MR SPECTROSCOPY
AB We conducted a systematic review and meta-analysis of proton magnetic resonance spectroscopy (1H-MRS) studies comparing autism spectrum disorder (ASD) patients with healthy controls, with the aim of profiling ASD-associated changes in the metabolites N-acetyl-aspartate (NAA) and Creatine (Cr). Meta-regression models of NAA and Cr levels were employed, using data from 20 eligible studies (N = 852), to investigate age-dependent differences in both global brain and region-specific metabolite levels, while controlling for measurement method (Cr-ratio versus absolute concentrations). Decreased NAA concentrations that were specific to children were found for whole-brain grey and white matter. In addition, a significant decrease in NAA was evident across age categories in the parietal cortex, the cerebellum, and the anterior cingulate cortex. Higher levels of Cr were observed for ASD adults than children in global grey matter, with specific increases for adults in the temporal lobe and decreased Cr in the occipital lobe in children. No differences were found for either NAA or Cr in the frontal lobes. These data provide some evidence that ASD is characterized by age-dependent fluctuations in metabolite levels across the whole brain and at the level of specific regions thought to underlie ASD-associated behavioural and affective deficits. Differences in Cr as a function of age and brain region suggests caution in the interpretation of Cr-based ratio measures of metabolites. Despite efforts to control for sources of heterogeneity, considerable variability in metabolite levels was observed in frontal and temporal regions, warranting further investigation.
C1 [Ipser, Jonathan C.; Syal, Supriya; Bentley, Judy; Adnams, Colleen M.; Stein, Dan J.] Univ Cape Town, Dept Psychiat & Mental Hlth, ZA-7925 Cape Town, South Africa.
[Steyn, Bennie] Univ Stellenbosch, Dept Psychiat, Cape Town, South Africa.
RP Ipser, JC (reprint author), Univ Cape Town, Dept Psychiat & Mental Hlth, ZA-7925 Cape Town, South Africa.
EM jonathanipser@gmail.com
RI Stein, Dan/A-1752-2008
OI Stein, Dan/0000-0001-7218-7810
CR ALLEN G, 2005, CLIN NEUROPSYCHIATRY, V6, P321
Allen G, 2003, AM J PSYCHIAT, V160, P262, DOI 10.1176/appi.ajp.160.2.262
American Psychiatric Association, 2000, DIAGN STAT MAN MENT
Autism and Developmental Disabilities Monitoring Network ( ADDM), 2009, MORBIDITY MORTALITY, V58, pSS
Bailey A, 1998, BRAIN, V121, P889, DOI 10.1093/brain/121.5.889
Baron-Cohen S, 2004, J AUTISM DEV DISORD, V34, P163, DOI 10.1023/B:JADD.0000022607.19833.00
Belmonte MK, 2004, J NEUROSCI, V24, P9228, DOI 10.1523/JNEUROSCI.3340-04.2004
Bernardi S, 2011, BRAIN RES, V1380, P198, DOI 10.1016/j.brainres.2010.12.057
Brand A, 1993, DEV NEUROSCI, V15, P298
Brugha TS, 2011, ARCH GEN PSYCHIAT, V68, P459, DOI 10.1001/archgenpsychiatry.2011.38
Buxbaum LJ, 2005, COGNITIVE BRAIN RES, V25, P226, DOI 10.1016/j.cogbrainres.2005.05.014
Chugani DC, 1999, PROG NEURO-PSYCHOPH, V23, P635, DOI 10.1016/S0278-5846(99)00022-6
Clark JB, 1998, DEV NEUROSCI, V20, P276
CONNELLY A, 1994, NEUROLOGY, V44, P1411
Courchesne E, 2005, CURR OPIN NEUROBIOL, V15, P225, DOI 10.1016/j.conb.2005.03.001
Courchesne E, 2004, MENT RETARD DEV D R, V10, P106, DOI 10.1002/mrdd.20020
Critchley HD, 2000, BRAIN, V123, P2203, DOI 10.1093/brain/123.11.2203
Czeh B, 2001, P NATL ACAD SCI USA, V98, P12796, DOI 10.1073/pnas.211427898
Deeks J, 2008, COCHRANE REV HDB 5 0
Demougeot C, 2001, J NEUROCHEM, V77, P408, DOI 10.1046/j.1471-4159.2001.00285.x
DEVINSKY O, 1995, BRAIN, V118, P279, DOI 10.1093/brain/118.1.279
DeVito TJ, 2007, BIOL PSYCHIAT, V61, P465, DOI 10.1016/j.biopsych.2006.07.022
Dhar SU, 2009, MOL GENET METAB, V96, P38, DOI 10.1016/j.ymgme.2008.10.008
Di Martino A, 2009, BIOL PSYCHIAT, V65, P63, DOI 10.1016/j.biopsych.2008.09.022
Endo T, 2007, BIOL PSYCHIAT, V62, P1030, DOI 10.1016/j.biopsych.2007.05.015
ERECINSKA M, 1990, PROG NEUROBIOL, V35, P245, DOI 10.1016/0301-0082(90)90013-7
Fayed N, 2005, ACAD RADIOL, V12, P566, DOI 10.1016/j.acra.2005.01.016
Friedman SD, 2003, NEUROLOGY, V60, P100
Friedman SD, 2006, ARCH GEN PSYCHIAT, V63, P786, DOI 10.1001/archpsyc.63.7.786
Frith U, 2001, CURR DIR PSYCHOL SCI, V10, P151, DOI 10.1111/1467-8721.00137
Fujii Emiko, 2010, J Med Invest, V57, P35
Gabis L, 2008, J CHILD NEUROL, V23, P766, DOI 10.1177/0883073808315423
Ganz ML, 2007, ARCH PEDIAT ADOL MED, V161, P343, DOI 10.1001/archpedi.161.4.343
Gervais H, 2004, NAT NEUROSCI, V7, P801, DOI 10.1038/nn1291
Hadjikhani N, 2004, NEUROIMAGE, V22, P1141, DOI 10.1016/j.neuroimage.2004.03.025
Hadjikhani N, 2006, CEREB CORTEX, V16, P1276, DOI 10.1093/cercor/bh069
Harada M, 2011, J AUTISM DEV DISORD, V41, P447, DOI 10.1007/s10803-010-1065-0
Hardan AY, 2008, PSYCHIAT RES-NEUROIM, V163, P97, DOI 10.1016/j.pscychresns.2007.12.002
Hashimoto T, 1998, ACTA NEUROL SCAND, V98, P8
Hashimoto T, 1997, J CHILD NEUROL, V12, P91
HASHIMOTO T, 1995, J AUTISM DEV DISORD, V25, P1, DOI 10.1007/BF02178163
Haznedar MM, 2000, AM J PSYCHIAT, V157, P1994, DOI 10.1176/appi.ajp.157.12.1994
Hedges L, 1985, STAT METHODS METAANA
Herbert MR, 2004, ANN NEUROL, V55, P530, DOI 10.1002/ana.20032
Hisaoka S, 2001, NEURORADIOLOGY, V43, P496
Just MA, 2007, CEREB CORTEX, V17, P951, DOI 10.1093/cercor/bhl006
KEMPER TL, 1993, NEUROL CLIN, V11, P175
Kleinhans NM, 2007, BRAIN RES, V1162, P85, DOI 10.1016/j.brainres.2007.04.081
Kleinhans NM, 2009, J AUTISM DEV DISORD, V39, P1079, DOI 10.1007/s10803-009-0707-6
Knapp G, 2003, STAT MED, V22, P2693, DOI 10.1002/sim.1482
Koshino H, 2005, NEUROIMAGE, V24, P810, DOI 10.1016/j.neuroimage.2004.09.028
Le Couteur A., 2003, AUTISM DIAGNOSTIC IN
Leslie KR, 2004, NEUROIMAGE, V21, P601, DOI 10.1016/j.neuroimage.2003.09.038
Levitt JG, 2003, BIOL PSYCHIAT, V54, P1355, DOI 10.1016/S0006-3223(03)00688-7
Li BSY, 2003, MAGN RESON IMAGING, V21, P923, DOI 10.1016/S0730-725X(03)00181-4
Lollgen H, 2009, INT J SPORTS MED, V30, P213, DOI 10.1055/s-0028-1128150
Lord C., 1999, AUTISM DIAGNOSTIC OB
Lundbom N, 2001, EPILEPSIA, V42, P1507, DOI 10.1046/j.1528-1157.2001.15301.x
McAlonan GM, 2002, BRAIN, V125, P1594, DOI 10.1093/brain/awf150
Miller BL, 1996, LIFE SCI, V58, P1929, DOI 10.1016/0024-3205(96)00182-8
Moffett JR, 2007, PROG NEUROBIOL, V81, P89, DOI 10.1016/j.pneurobio.2006.12.003
Muller RA, 2003, AM J PSYCHIAT, V160, P1847, DOI 10.1176/appi.ajp.160.10.1847
Murphy DGM, 2011, BRAIN RES, V1380, P22, DOI 10.1016/j.brainres.2010.10.042
Murphy DGM, 2002, ARCH GEN PSYCHIAT, V59, P885, DOI 10.1001/archpsyc.59.10.885
Murphy FC, 2003, COGN AFFECT BEHAV NE, V3, P207, DOI 10.3758/CABN.3.3.207
Nasrallah F, 2010, PEDIATR NEUROL, V42, P163, DOI [10.1016/j.pediatrneurol.2009.07.015, 10.1016/j.pediatrneurol.2009.07.15]
Nordahl CW, 2007, J NEUROSCI, V27, P11725, DOI 10.1523/JNEUROSCI.0777-07.2007
O'Brien FM, 2010, PSYCHIAT RES-NEUROIM, V184, P77, DOI 10.1016/j.pscychresns.2010.08.007
Ohnishi T, 2000, BRAIN, V123, P1838, DOI 10.1093/brain/123.9.1838
Oner O, 2007, AM J NEURORADIOL, V28, P1494, DOI 10.3174/ajnr.A0625
Otsuka H, 1999, NEURORADIOLOGY, V41, P517
Page LA, 2006, AM J PSYCHIAT, V163, P2189, DOI 10.1176/appi.ajp.163.12.2189
Palmen SJMC, 2004, J AUTISM DEV DISORD, V34, P603, DOI 10.1007/s10803-004-5282-2
Piven J, 2011, J AM GERIATR SOC, V59, P2151, DOI 10.1111/j.1532-5415.2011.03632.x
RITVO ER, 1986, AM J PSYCHIAT, V143, P862
Rogers SJ, 2003, J CHILD PSYCHOL PSYC, V44, P763, DOI 10.1111/1469-7610.00162
SAGER TN, 1995, J CEREBR BLOOD F MET, V15, P639
Salmond CH, 2007, CORTEX, V43, P686, DOI 10.1016/S0010-9452(08)70498-2
Sartorius A, 2008, J NEUROSCI METH, V172, P215, DOI 10.1016/j.jneumeth.2008.04.028
Schirmer T, 2000, NMR BIOMED, V13, P28, DOI 10.1002/(SICI)1099-1492(200002)13:1<28::AID-NBM606>3.0.CO;2-L
Schultz RT, 2005, INT J DEV NEUROSCI, V23, P125, DOI 10.1016/j.ijdevneu.2004.12.012
Schumann CM, 2004, J NEUROSCI, V24, P6392, DOI 10.1523/JNEUROSCI.1297-04.2004
Simister RJ, 2002, EPILEPSIA, V43, P1021, DOI 10.1046/j.1528-1157.2002.50701.x
Soares DP, 2009, CLIN RADIOL, V64, P12, DOI 10.1016/j.crad.2008.07.002
Stromberger C, 2003, J INHERIT METAB DIS, V26, P299, DOI 10.1023/A:1024453704800
Talairach J., 1988, COPLANAR STEREOTAXIC
TALLAN HH, 1956, J BIOL CHEM, V219, P257
URENJAK J, 1993, J NEUROSCI, V13, P981
Viechtbauer W, 2010, J STAT SOFTW, V36, P1
Wallace GL, 2010, BRAIN, V133, P3745, DOI 10.1093/brain/awq279
Wechsler D, 1997, WECHSLER ADULT INTEL, V3rd
Wechsler D, 1991, WECHSLER INTELLIGENC, V3rd
NR 92
TC 8
Z9 8
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0885-7490
J9 METAB BRAIN DIS
JI Metab. Brain Dis.
PD SEP
PY 2012
VL 27
IS 3
BP 275
EP 287
DI 10.1007/s11011-012-9293-y
PG 13
WC Endocrinology & Metabolism; Neurosciences
SC Endocrinology & Metabolism; Neurosciences & Neurology
GA 981GC
UT WOS:000306953900005
PM 22426803
ER
PT J
AU Syal, S
Hattingh, CJ
Fouche, JP
Spottiswoode, B
Carey, PD
Lochner, C
Stein, DJ
AF Syal, Supriya
Hattingh, Coenraad J.
Fouche, Jean-Paul
Spottiswoode, Bruce
Carey, Paul D.
Lochner, Christine
Stein, Dan J.
TI Grey matter abnormalities in social anxiety disorder: a pilot study
SO METABOLIC BRAIN DISEASE
LA English
DT Article
DE Social anxiety disorder; MRI; Structural abnormalities; Cortical
thickness; Social behaviour
ID AUTISM SPECTRUM DISORDERS; MAGNETIC-RESONANCE IMAGES; PREFRONTAL CORTEX;
FUNCTIONAL NEUROANATOMY; SEMANTIC DEMENTIA; EMOTIONAL FACES; NEURAL
SYSTEMS; AMYGDALA; ACTIVATION; BRAIN
AB While a number of studies have explored the functional neuroanatomy of social anxiety disorder (SAD), data on grey matter integrity are lacking. We conducted structural MRI scans to examine the cortical thickness of grey matter in individuals with SAD. 13 unmedicated adult patients with a primary diagnosis of generalized social anxiety disorder and 13 demographically (age, gender and education) matched healthy controls underwent 3T structural magnetic resonance imaging. Cortical thickness and subcortical volumes were estimated using an automated algorithm (Freesurfer Version 4.5). Compared to controls, social anxiety disorder patients showed significant bilateral cortical thinning in the fusiform and post central regions. Additionally, right hemisphere specific thinning was found in the frontal, temporal, parietal and insular cortices of individuals with social anxiety disorder. Although uncorrected cortical grey matter volumes were significantly lower in individuals with SAD, we did not detect volumetric differences in corrected amygdala, hippocampal or cortical grey matter volumes across study groups. Structural differences in grey matter thickness between SAD patients and controls highlight the diffuse neuroanatomical networks involved in both social anxiety and social behavior. Additional work is needed to investigate the causal mechanisms involved in such structural abnormalities in SAD.
C1 [Syal, Supriya; Hattingh, Coenraad J.; Stein, Dan J.] Univ Cape Town, Dept Psychiat & Mental Hlth, ZA-7925 Cape Town, South Africa.
[Carey, Paul D.; Lochner, Christine; Stein, Dan J.] Univ Stellenbosch, Dept Psychiat, MRC Unit Anxiety & Stress Disorders, Cape Town, South Africa.
[Fouche, Jean-Paul; Spottiswoode, Bruce] Univ Cape Town, Dept Human Biol, MRC UCT Med Imaging Res Unit, ZA-7925 Cape Town, South Africa.
RP Syal, S (reprint author), Univ Cape Town, Dept Psychiat & Mental Hlth, ZA-7925 Cape Town, South Africa.
EM supriya.syal@uct.ac.za
RI Stein, Dan/A-1752-2008
OI Stein, Dan/0000-0001-7218-7810
FU Claude Leon Foundation
FX Dr. Supriya Syal is supported by a Claude Leon Foundation Postdoctoral
Fellowship. We would like to thank Dr. Henri Cararra for his advice on
statistical analyses.
CR Amir N, 2005, BIOL PSYCHIAT, V57, P975, DOI 10.1016/j.biopsych.2005.01.044
Association A.P., 2000, DIAGN STAT MAN MENT, P943
Aylward E, 1999, NEUROL
Bandelow B, 2004, SOCIAL ANXIETY DISOR, P366
Beaton EA, 2009, SOC NEUROSCI, V4, P308, DOI 10.1080/17470910902801021
Bechdolf A, 2012, PSYCHIAT RES-NEUROIM, V201, P34, DOI 10.1016/j.pscychresns.2011.06.010
Beer J, 2003, J PERS
Beer JS, 2006, ORBITOFRONTAL CORTEX
Benjamini Y., 1995, J ROY STAT SOC B
Blair K, 2008, AM J PSYCHIAT, V165, P1193, DOI 10.1176/appi.ajp.2008.07071060
Brookeman J, 1990, MAGN RESON
Camus M, 2009, EUR J NEUROSCI, V30, P1980, DOI 10.1111/j.1460-9568.2009.06991.x
Carr L, 2003, P NATL ACAD SCI USA, V100, P5497, DOI 10.1073/pnas.0935845100
Cohen MX, 2009, NAT NEUROSCI, V12, P32, DOI 10.1038/nn.2228
Cooney R, 2006, PSYCHIAT RES
Critchley HD, 2000, BRAIN, V123, P2203, DOI 10.1093/brain/123.11.2203
Critchley HD, 2004, NAT NEUROSCI, V7, P189, DOI 10.1038/nn1176
Dale AM, 1999, NEUROIMAGE, V9, P179, DOI 10.1006/nimg.1998.0395
Deardorff P, 1977, PSYCHOL
Deary I, 2005, J EPIDEMIOL COMMUNIT
De Bellis MD, 2000, BIOL PSYCHIAT, V48, P51, DOI 10.1016/S0006-3223(00)00835-0
Deeley Q, 2007, BIOL PSYCHIAT, V62, P207, DOI 10.1016/j.biopsych.2006.09.037
Demaree Heath A, 2005, Behav Cogn Neurosci Rev, V4, P3, DOI 10.1177/1534582305276837
Denkova E, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0014150
Desikan R, 2006, NEUROIMAGE
Ebisch SJH, 2011, HUM BRAIN MAPP, V32, P1013, DOI 10.1002/hbm.21085
Etkin A, 2007, AM J PSYCHIAT
Fellows LK, 2011, ANN NY ACAD SCI, V1239, P51, DOI 10.1111/j.1749-6632.2011.06229.x
First Michael B, 1997, USERS GUIDE STRUCTUR
Fischl B, 2000, P NATL ACAD SCI USA, V97, P11050, DOI 10.1073/pnas.200033797
Fischl B, 2002, NEURON, V33, P341, DOI 10.1016/S0896-6273(02)00569-X
Fischl B, 2004, NEUROIMAGE, V23, pS69, DOI 10.1016/j.neuroimage.2004.07.016
Fischl B, 2004, CEREBR
Fischl B, 1999, NEUROIMAGE
Fornito A, 2009, SCHIZOPHR RES, V108, P104, DOI 10.1016/j.schres.2008.12.011
FRANZEN EA, 1973, NEUROPSYCHOLOGIA, V11, P141, DOI 10.1016/0028-3932(73)90002-X
Fusar-Poli P, 2009, J PSYCHIATR NEUROSCI, V34, P418
Gentili C, 2008, BRAIN RES
Glosser G, 2000, J NEUROL NEUROSUR PS, V68, P53, DOI 10.1136/jnnp.68.1.53
Goldin PR, 2009, ARCH GEN PSYCHIAT, V66, P170, DOI 10.1001/archgenpsychiatry.2008.525
Hadjikhani N, 2006, CEREB CORTEX, V16, P1276, DOI 10.1093/cercor/bh069
Hahn A, 2011, NEUROIMAGE, V56, P881, DOI 10.1016/j.neuroimage.2011.02.064
Hampton AN, 2007, NEURON, V55, P545, DOI 10.1016/j.neuron.2007.07.022
Heimberg RG, 1999, PSYCHOL MED, V29, P199, DOI 10.1017/S0033291798007879
Irle E, 2010, J PSYCHIATR NEUROSCI, V35, P126, DOI 10.1503/jpn.090041
Kaufman AS, 2006, ASSESSING ADOLESCENT, P796
Kaufman AS, 2009, IQ TESTING 101, P347
Klumpp H, 2011, BIOL PSYCHOL
Kucharska-Pietura K, 2003, NEUROPSYCHOLOGIA, V41, P1082, DOI 10.1016/S0028-3932(02)00294-4
Lebreton M, 2009, EUR J NEUROSCI
Leibowitz M, 1987, MODERN PROBLEMS PHAR, V22, P141
Leslie KR, 2004, NEUROIMAGE, V21, P601, DOI 10.1016/j.neuroimage.2003.09.038
Liao W, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0015238
Liao W, 2011, BRAIN RES, V1388, P167, DOI 10.1016/j.brainres.2011.03.018
Lorberbaum J, 2004, NEUROREPORT
MESULAM MM, 1982, J COMP NEUROL, V212, P38, DOI 10.1002/cne.902120104
Miyahara M, 2013, SOC COGN AFFECT NEUR, V8, P181, DOI 10.1093/scan/nsr085
Monk CS, 2008, ARCH GEN PSYCHIAT, V65, P568, DOI 10.1001/archpsyc.65.5.568
Narumoto J, 2001, COGNITIVE BRAIN RES, V12, P225, DOI 10.1016/S0926-6410(01)00053-2
Negd M, 2011, BEHAV RES THER, V49, P852, DOI 10.1016/j.brat.2011.09.008
Newman-Norlund RD, 2009, SOC COGN AFFECT NEUR, V4, P10, DOI 10.1093/scan/nsn028
Ochsner KN, 2005, TRENDS COGN SCI, V9, P242, DOI 10.1016/j.tics.2005.03.010
Olson IR, 2007, BRAIN, V130, P1718, DOI 10.1093/brain/awm052
Paulus MP, 2010, BRAIN STRUCT FUNCT, V214, P451, DOI 10.1007/s00429-010-0258-9
Petrides M, 2007, J NEUROSCI, V27, P11573, DOI 10.1523/JNEUROSCI.2419-07.2007
Phan K, 2006, BIOL PSYCHIAT
Phan KL, 2002, NEUROIMAGE, V16, P331, DOI 10.1006/nimg.2002.1087
Phan KL, 2009, BIOL PSYCHIAT, V66, P691, DOI 10.1016/j.biopsych.2009.02.028
Potts N, 1994, PSYCHIAT RES
Prehn-Kristensen A, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0005987
Preston S, 2002, BRAIN BRAIN
Pujol J, 2009, PSYCHOL MED, V39, P1177, DOI 10.1017/S003329170800500X
Rizzolatti G., 2004, ANN REV NEUROSCI
Sabatinelli D, 2005, NEUROIMAGE, V24, P1265, DOI 10.1016/j.neuroimage.2004.12.015
Sareen J, 2007, BIOL
Schultz RT, 2003, PHILOS T ROY SOC B, V358, P415, DOI 10.1098/rstb.2002.1208
Snowden JS, 2003, NEUROPSYCHOLOGIA, V41, P688, DOI 10.1016/S0028-3932(02)00221-X
Snowden JS, 2004, BRAIN, V127, P860, DOI 10.1093/brain/awh099
Stein M, 2008, LANCET
Stein MB, 2002, ARCH GEN PSYCHIAT, V59, P1027, DOI 10.1001/archpsyc.59.11.1027
Straube T, 2004, BIOL PSYCHIAT, V56, P921, DOI 10.1016/j.biopsych.2004.09.024
Thompson SA, 2003, NEUROLOGY, V61, P1196
van Tol MJ, 2010, ARCH GEN PSYCHIAT, V67, P1002, DOI 10.1001/archgenpsychiatry.2010.121
Vollm B, 2006, NEUROIMAGE
Vuilleumier P, 2004, NAT NEUROSCI, V7, P1271, DOI 10.1038/nn1341
Waiter GD, 2004, NEUROIMAGE, V22, P619, DOI 10.1016/j.neuroimage.2004.02.029
Wallace GL, 2010, BRAIN, V133, P3745, DOI 10.1093/brain/awq279
Wood Jacqueline N, 2003, Behav Cogn Neurosci Rev, V2, P97, DOI 10.1177/1534582303253625
Yamasaki S, 2010, BIOL PSYCHIAT, V68, P1141, DOI 10.1016/j.biopsych.2010.07.012
Zhou W, 2011, NEUROIMAGE, V55, P1401, DOI 10.1016/j.neuroimage.2010.12.064
NR 90
TC 17
Z9 17
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0885-7490
J9 METAB BRAIN DIS
JI Metab. Brain Dis.
PD SEP
PY 2012
VL 27
IS 3
BP 299
EP 309
DI 10.1007/s11011-012-9299-5
PG 11
WC Endocrinology & Metabolism; Neurosciences
SC Endocrinology & Metabolism; Neurosciences & Neurology
GA 981GC
UT WOS:000306953900007
PM 22527992
ER
PT J
AU Foley, AG
Gannon, S
Rombach-Mullan, N
Prendergast, A
Barry, C
Cassidy, AW
Regan, CM
AF Foley, Andrew G.
Gannon, Shane
Rombach-Mullan, Nanette
Prendergast, Alison
Barry, Claire
Cassidy, Andrew W.
Regan, Ciaran M.
TI Class I histone deacetylase inhibition ameliorates social cognition and
cell adhesion molecule plasticity deficits in a rodent model of autism
spectrum disorder
SO NEUROPHARMACOLOGY
LA English
DT Article
DE Histone deacetylase; SAHA; MS-275; Social interaction; Biological
motion; Spatial learning; Synaptic plasticity; NCAM PSA
ID VALPROIC ACID; MEMORY FORMATION; DEVELOPMENTAL ANOMALIES; BIOLOGICAL
MOTION; ANIMAL-MODEL; MUTANT MICE; MOUSE MODEL; ADULT-RAT; N-CAM;
EXPRESSION
AB In utero exposure of rodents to valproic acid (VPA), a histone deacetylase (HDAC) inhibitor, has been proposed to induce an adult phenotype with behavioural characteristics reminiscent of those observed in autism spectrum disorder (ASD). We have evaluated the face validity of this model in terms of social cognition deficits which are a major core symptom of ASD. We employed the social approach avoidance paradigm as a measure of social reciprocity, detection of biological motion that is crucial to social interactions, and spatial learning as an indicator of dorsal stream processing of social cognition and found each parameter to be significantly impaired in Wistar rats with prior in utero exposure to VPA. We found no significant change in the expression of neural cell adhesion molecule polysialylation state (NCAM PSA), a measure of construct validity, but a complete inability to increase its glycosylation state which is necessary to mount the neuroplastic response associated with effective spatial learning. Finally, in all cases, we found chronic HDAC inhibition, with either pan-specific or HDAC1-3 isoform-specific inhibitors, to significantly ameliorate deficits in both social cognition and its associated neuroplastic response. We conclude that in utero exposure to VPA provides a robust animal model for the social cognitive deficits of ASD and a potential screen for the development of novel therapeutics for this condition. (C) 2012 Elsevier Ltd. All rights reserved.
C1 [Regan, Ciaran M.] Univ Coll Dublin, UCD Conway Inst, Sch Biomol & Biomed Sci, Dublin 4, Ireland.
[Foley, Andrew G.; Gannon, Shane; Rombach-Mullan, Nanette; Prendergast, Alison; Barry, Claire; Cassidy, Andrew W.] Univ Coll Dublin, NovaUCD, Dublin 4, Ireland.
RP Regan, CM (reprint author), Univ Coll Dublin, UCD Conway Inst, Sch Biomol & Biomed Sci, Dublin 4, Ireland.
EM ciaran.regan@ucd.ie
FU Berand
FX AF is a current employee of Berand Neuropharmacology, AF and CR are
members of the Board of Directors for Berand Neuropharmacology. All
other authors are past employees of Berand Neuropharmacology. Berand
provided financial support for the conduct of the research and in the
preparation of the article.
CR Abrahams BS, 2010, ARCH NEUROL-CHICAGO, V67, P395, DOI 10.1001/archneurol.2010.47
Alarcon JM, 2004, NEURON, V42, P947, DOI 10.1016/j.neuron.2004.05.021
American Psychiatric Association, 2006, DIAGN STAT MAN MENT
Annaz D, 2012, J AUTISM DEV DISORD, V42, P401, DOI 10.1007/s10803-011-1256-3
BARBEAU D, 1995, P NATL ACAD SCI USA, V92, P2785, DOI 10.1073/pnas.92.7.2785
Beckers T, 2007, INT J CANCER, V121, P1138, DOI 10.1002/ijc.22751
Blake R, 2007, ANNU REV PSYCHOL, V58, P47, DOI 10.1146/annurev.psych.57.102904.190152
Bolden JE, 2006, NAT REV DRUG DISCOV, V5, P769, DOI 10.1038/nrd2133
Brodkin ES, 2004, BRAIN RES, V1002, P151, DOI 10.1016/j.brainres.2003.12.013
Bussey TJ, 2008, LEARN MEMORY, V15, P516, DOI 10.1101/lm.987808
Calandreau L, 2010, GENES BRAIN BEHAV, V9, P958, DOI 10.1111/j.1601-183X.2010.00635.x
CHRISTIANSON AL, 1994, DEV MED CHILD NEUROL, V36, P361
Courchesne E, 2011, BRAIN RES, V1380, P138, DOI 10.1016/j.brainres.2010.09.101
DOYLE E, 1992, J NEUROSCI RES, V31, P513, DOI 10.1002/jnr.490310315
Eikel D, 2006, CHEM RES TOXICOL, V19, P272, DOI 10.1021/tx0502241
Fox GB, 1995, INT J DEV NEUROSCI, V13, P663, DOI 10.1016/0736-5748(95)00067-4
FOX GB, 1995, J NEUROCHEM, V65, P2796
Glaser KB, 2004, BIOCHEM BIOPH RES CO, V325, P683, DOI 10.1016/j.bbrc.2004.10.082
Gräff Johannes, 2011, Physiol Rev, V91, P603, DOI 10.1152/physrev.00012.2010
Guan JS, 2009, NATURE, V459, P55, DOI 10.1038/nature07925
Ingram JL, 2000, NEUROTOXICOL TERATOL, V22, P319, DOI 10.1016/S0892-0362(99)00083-5
Kazantsev AG, 2008, NAT REV DRUG DISCOV, V7, P854, DOI 10.1038/nrd2681
Kilgore M, 2010, NEUROPSYCHOPHARMACOL, V35, P870, DOI 10.1038/npp.2009.197
Lampen A, 2005, MOL PHARMACOL, V68, P193, DOI 10.1124/mol.104.009340
Levenson JM, 2004, J BIOL CHEM, V279, P40545, DOI 10.1074/jbc.M402229200
LYONS F, 1988, BIOL PSYCHIAT, V23, P769, DOI 10.1016/0006-3223(88)90065-0
MacKinnon LM, 2010, EXP BRAIN RES, V205, P571, DOI 10.1007/s00221-010-2378-0
Maguire EA, 2000, P NATL ACAD SCI USA, V97, P4398, DOI 10.1073/pnas.070039597
Markram K, 2008, NEUROPSYCHOPHARMACOL, V33, P901, DOI 10.1038/sj.npp.1301453
McQuown SC, 2011, J NEUROSCI, V31, P764, DOI 10.1523/JNEUROSCI.5052-10.2011
Milne E, 2005, CAH PSYCHOL COGN, V23, P3
Miyazaki K, 2005, INT J DEV NEUROSCI, V23, P287, DOI 10.1016/j.ijdevneu.2004.05.004
MOSER E, 1993, J NEUROSCI, V13, P3916
Murphy KJ, 1996, J NEUROCHEM, V67, P1268
Murphy KJ, 2010, J NEUROCHEM, V113, P601, DOI 10.1111/j.1471-4159.2010.06617.x
Murphy KJ, 2006, NEUROPSYCHOPHARMACOL, V31, P90, DOI 10.1038/sj.npp.1300810
Ni Dhuill C.M., 1999, J NEUROSCI RES, V55, P99
Paxinos G, 2007, RAT BRAIN STEREOTAXI, V6th
Peca J, 2011, NATURE, V472, P437, DOI 10.1038/nature09965
PERSOHN E, 1989, J COMP NEUROL, V288, P92, DOI 10.1002/cne.902880108
Pinto D, 2010, NATURE, V466, P368, DOI 10.1038/nature09146
Plioplys A V, 1990, J Neuropsychiatry Clin Neurosci, V2, P413
Purcell AE, 2001, J AUTISM DEV DISORD, V31, P183, DOI 10.1023/A:1010751232295
Rasalam AD, 2005, DEV MED CHILD NEUROL, V47, P551, DOI 10.1017/S0012162205001076
Rodier PM, 1996, J COMP NEUROL, V370, P247, DOI 10.1002/(SICI)1096-9861(19960624)370:2<247::AID-CNE8>3.0.CO;2-2
Rutherford MD, 2012, J AUTISM DEV DISORD, V42, P557, DOI 10.1007/s10803-011-1267-0
Sakai Y, 2011, SCI TRANSL MED, V3, DOI 10.1126/scitranslmed.3002166
Samaco RC, 2011, J NEUROSCI, V31, P7951, DOI 10.1523/JNEUROSCI.0169-11.2011
Sandi C, 2004, LEARN MEMORY, V11, P244, DOI 10.1101/lm.73904
Schneider T, 2005, NEUROPSYCHOPHARMACOL, V30, P80, DOI 10.1038/sj.npp.1300518
Silverman JL, 2010, NEUROPSYCHOPHARMACOL, V35, P976, DOI 10.1038/npp.2009.201
Simonini MV, 2006, P NATL ACAD SCI USA, V103, P1587, DOI 10.1073/pnas.0510341103
Spencer J, 2000, NEUROREPORT, V11, P2765, DOI 10.1097/00001756-200008210-00031
Stork O, 2000, EUR J NEUROSCI, V12, P3291, DOI 10.1046/j.1460-9568.2000.00197.x
Tanaka Y, 2007, HUM PSYCHOPHARM CLIN, V22, P97, DOI 10.1002/hup.828
Tashiro Y, 2011, INT J DEV NEUROSCI, V29, P359, DOI 10.1016/j.ijdevneu.2011.03.008
Tordjman S, 2007, BEHAV GENET, V37, P61, DOI 10.1007/s10519-006-9120-5
Vallortigara G, 2005, PLOS BIOL, V3, P1312, DOI 10.1371/journal.pbio.0030208
VORHEES CV, 1987, TERATOLOGY, V35, P195, DOI 10.1002/tera.1420350205
Wagner GC, 2006, J AUTISM DEV DISORD, V36, P779, DOI 10.1007/s10803-006-0117-y
Wang, 2009, NATURE, V459, P528
Wegiel J, 2010, ACTA NEUROPATHOL, V119, P755, DOI 10.1007/s00401-010-0655-4
Witter MP, 2006, TRENDS NEUROSCI, V29, P671, DOI 10.1016/j.tins.2006.10.003
Ye HH, 2010, NEUROSIGNALS, V18, P62, DOI 10.1159/000322543
NR 64
TC 14
Z9 15
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0028-3908
J9 NEUROPHARMACOLOGY
JI Neuropharmacology
PD SEP
PY 2012
VL 63
IS 4
BP 750
EP 760
DI 10.1016/j.neuropharm.2012.05.042
PG 11
WC Neurosciences; Pharmacology & Pharmacy
SC Neurosciences & Neurology; Pharmacology & Pharmacy
GA 977DX
UT WOS:000306637700027
PM 22683514
ER
PT J
AU Glumbic, N
Brojcin, B
AF Glumbic, Nenad
Brojcin, Branislav
TI Factor structure of the Serbian version of the Children's Communication
Checklist-2
SO RESEARCH IN DEVELOPMENTAL DISABILITIES
LA English
DT Article
DE Pragmatics; Language; Autism; Impairment
ID AUTISM SPECTRUM DISORDERS; AUDITORY PROCESSING DISORDER; LANGUAGE
IMPAIRMENT; PRAGMATIC LANGUAGE; TEACHER REPORT; PERCEPTION; SPEECH;
PARENT; SLI; CCC
AB Keeping in mind that traditional tests were largely insensitive to pragmatic impairment, Bishop (2003) created a second version of the Children's Communication Checklist (CCC-2) in order to identify pragmatic deficits in children with communication problems. Unfortunately, it was revealed that certain subscales of the Serbian version of the CCC-2 have unacceptably low internal consistency. Because dividing the test into original subscales did not apply for the Serbian population, the aim of this paper was to determine the factor structure of the CCC-2. The sample consisted of 1344 typically developing, monolingual participants of both sexes, aged from 4 to 17 (M = 9.52; SD = 2.72). Participants were recruited from three statistical regions in Serbia. All participants attended regular kindergarten, elementary or secondary schools. CCC-2 factor analysis was determined by using the principal component method, with Varimax rotation of principal axes. A factor analysis showed that the CCC-2 had three factors (General Communication Ability, Pragmatics and Structural Language Aspects), which accounted for 29.39% of the total variance. A three-factor solution should be further confirmed in the course of a clinical validation of the CCC-2. (C) 2012 Elsevier Ltd. All rights reserved.
C1 [Glumbic, Nenad; Brojcin, Branislav] Univ Belgrade, Fac Special Educ & Rehabil, Belgrade 11000, Serbia.
RP Brojcin, B (reprint author), Univ Belgrade, Fac Special Educ & Rehabil, Visokog Stevana 2, Belgrade 11000, Serbia.
EM branislav06@gmail.com
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
Bignell S, 2007, BRIT J DEV PSYCHOL, V25, P499, DOI 10.1348/026151006X171343
Bishop D. V. M., 2003, CHILDRENS COMMUNICAT
Bishop DVM, 2009, INT J LANG COMM DIS, V44, P600, DOI 10.1080/13682820802259662
Bishop DVM, 2011, ARCH DIS CHILD, V96, P954, DOI 10.1136/adc.2009.179747
Bishop DVM, 1998, J CHILD PSYCHOL PSYC, V39, P879, DOI 10.1017/S0021963098002832
Bishop DVM, 2006, BEHAV GENET, V36, P173, DOI 10.1007/s10519-005-9020-0
Bishop DVM, 2006, AM J MED GENET B, V141B, P117, DOI 10.1002/ajmg.b.30267
BISHOP DVM, 1991, APPL PSYCHOLINGUIST, V12, P199, DOI 10.1017/S0142716400009140
Bishop DVM, 2001, DEV MED CHILD NEUROL, V43, P809, DOI 10.1017/S0012162201001475
Christensen L. J., 2007, THESIS B YOUNG U
Dawes P, 2010, ARCH DIS CHILD, V95, P432, DOI 10.1136/adc.2009.170118
Ferguson MA, 2011, J SPEECH LANG HEAR R, V54, P211, DOI 10.1044/1092-4388(2010/09-0167)
Geurts H, 2010, INT J LANG COMM DIS, V45, P436, DOI 10.3109/13682820903165685
Geurts H. M., 2007, CCC 2 NL CHILDRENS C
Geurts HM, 2008, J AUTISM DEV DISORD, V38, P1931, DOI 10.1007/s10803-008-0587-1
Geurts HM, 2009, INT J LANG COMM DIS, V44, P549, DOI 10.1080/13682820802243344
Glumbie N., 2010, BEOGRADSKA DEFEKTOLO, V16, P209
Glumbit N., 2010, SPECIJALNA EDUKACIJA, V9, P3
Grzadzinski R, 2011, J AUTISM DEV DISORD, V41, P1178, DOI 10.1007/s10803-010-1135-3
Helland WA, 2009, SCAND J PSYCHOL, V50, P287, DOI 10.1111/j.1467-9450.2009.00718.x
Johnson CP, 2007, PEDIATRICS, V120, P1183, DOI 10.1542/peds.2007-2361
Kehler A., 2004, HDB PRAGMATICS, P241
Kirchner D., 1983, PRAGMATIC ASSESSMENT, P29
Norbury CF, 2004, INT J LANG COMM DIS, V39, P345, DOI 10.1080/13682820410001654883
Phelps-Teraski D., 1992, TEST PRAGMATIC LANGU
Quach J., 2009, PEDIATRICS, V123, P287
Ramirez-Inscoe J, 2011, EAR HEARING, V32, P690, DOI 10.1097/AUD.0b013e31821f0538
Solomon M, 2011, SCHIZOPHR RES, V131, P146, DOI 10.1016/j.schres.2011.03.005
Statistical Office of the Republic of Serbia, 2003, CENS POP HOUS BOUS 2
Vezina M., 2011, CANADIAN J SPEECH LA, V35, P244
Volden J, 2009, J AUTISM DEV DISORD, V39, P388, DOI 10.1007/s10803-008-0618-y
Volden J, 2010, AM J SPEECH-LANG PAT, V19, P204, DOI 10.1044/1058-0360(2010/09-0011)
Waytz A, 2010, TRENDS COGN SCI, V14, P383, DOI 10.1016/j.tics.2010.05.006
Whitehouse AJO, 2008, J COMMUN DISORD, V41, P319, DOI 10.1016/j.jcomdis.2008.01.002
NR 35
TC 0
Z9 1
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0891-4222
J9 RES DEV DISABIL
JI Res. Dev. Disabil.
PD SEP-OCT
PY 2012
VL 33
IS 5
BP 1352
EP 1359
DI 10.1016/j.ridd.2012.03.010
PG 8
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA 962MO
UT WOS:000305549400003
PM 22522193
ER
PT J
AU Rumpf, AL
Kamp-Becker, I
Becker, K
Kauschke, C
AF Rumpf, Anna-Lena
Kamp-Becker, Inge
Becker, Katja
Kauschke, Christina
TI Narrative competence and internal state language of children with
Asperger Syndrome and ADHD
SO RESEARCH IN DEVELOPMENTAL DISABILITIES
LA English
DT Article
DE Autism spectrum disorders; Narrative competence; Internal state
language; Theory of mind; Weak central coherence; Asperger Syndrome;
ADHD
ID DEFICIT-HYPERACTIVITY DISORDER; AUTISM SPECTRUM DISORDERS; WEAK CENTRAL
COHERENCE; ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; PERVASIVE
DEVELOPMENTAL DISORDERS; HIGH-FUNCTIONING CHILDREN;
PSYCHIATRIC-DISORDERS; AFFECT RECOGNITION; STORY CHARACTERS; MIND
AB The central question of the present study was whether there are differences between children with Asperger Syndrome (AS), children with attention deficit hyperactivity disorder (ADHD) and healthy controls (HC) with respect to the organization of narratives and their verbalization of internal states. Oral narrations of a wordless picture book produced by 31 children (11 with AS, 9 with ADHD, 11 HC, aged 8-12) were analyzed regarding the following linguistic variables: story length, sentence structure and sentence complexity, coherence and cohesion of the stories, verbalization of the narrator's perspective, as well as internal state language (verbal reference to mental states). Considerable similarities were noted between the two clinical groups, which deviate from HC children. Narratives of the children with AS and ADHD were shorter than the narratives produced by the HC children. The children of both clinical groups failed to point out the main aspects of the story. In particular, children with AS did not refer to cognitive states as often as the other groups. With respect to narrative coherence, they produced fewer pronominal references than HC children and children with ADHD. In conclusion, the two clinical groups differed from the HC group on a number of features, and a less frequent reference to cognitive states was identified for the children with AS. (C) 2012 Elsevier Ltd. All rights reserved.
C1 [Rumpf, Anna-Lena; Kamp-Becker, Inge; Kauschke, Christina] Univ Marburg, Dept German Language Studies, D-35032 Marburg, Germany.
[Becker, Katja] Univ Marburg, Dept Child & Adolescent Psychiat Psychosomat & Ps, D-35033 Marburg, Germany.
RP Kamp-Becker, I (reprint author), Univ Marburg, Dept German Language Studies, D-35032 Marburg, Germany.
EM kampbeck@med.uni-marburg.de
CR ADRIEN JL, 1993, J AM ACAD CHILD PSY, V32, P617, DOI 10.1097/00004583-199305000-00019
American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th
Baron-Cohen S., 2000, UNDERSTANDING OTHER, P3
Baron-Cohen S, 2004, J AUTISM DEV DISORD, V34, P163, DOI 10.1023/B:JADD.0000022607.19833.00
Booth R, 2010, J EXP CHILD PSYCHOL, V107, P377, DOI 10.1016/j.jecp.2010.06.003
BRETHERTON I, 1982, DEV PSYCHOL, V18, P906, DOI 10.1037//0012-1649.18.6.906
Bruner J. S., 1990, ACTS MEANING
Capps L., 2000, J ABNORMAL CHILD PSY, V28, P193
Clark T, 1999, EUR CHILD ADOLES PSY, V8, P50
Colle L, 2008, J AUTISM DEV DISORD, V38, P28, DOI 10.1007/s10803-007-0357-5
Decety J, 2010, DEV NEUROSCI-BASEL, V32, P257, DOI 10.1159/000317771
Diehl JJ, 2006, J ABNORM CHILD PSYCH, V34, P87, DOI 10.1007/s10802-005-9003-x
Doepfner M., 2003, DIAGNOSTIC SYSTEM ME
Dziobek I, 2008, J AUTISM DEV DISORD, V38, P464, DOI 10.1007/s10803-007-0486-x
Frazier J. A., 2001, J ATTEN DISORD, V4, P203, DOI DOI 10.1177/108705470100400402
Frith C., 2005, CURR BIOL, V15, P644
Frith U, 1996, Acta Paediatr Suppl, V416, P63
Gargaro BA, 2011, NEUROSCI BIOBEHAV R, V35, P1081, DOI 10.1016/j.neubiorev.2010.11.002
Gauthier I, 2009, VISION RES, V49, P470, DOI 10.1016/j.visres.2008.12.007
Geschwind DH, 2009, ANNU REV MED, V60, P367, DOI 10.1146/annurev.med.60.053107.121225
Geurts HM, 2008, J AUTISM DEV DISORD, V38, P1931, DOI 10.1007/s10803-008-0587-1
GILLBERG CL, 1992, J CHILD PSYCHOL PSYC, V33, P813, DOI 10.1111/j.1469-7610.1992.tb01959.x
Gjevik E, 2011, J AUTISM DEV DISORD, V41, P761, DOI 10.1007/s10803-010-1095-7
Golan O, 2006, J AUTISM DEV DISORD, V36, P169, DOI 10.1007/s10803-005-0057-y
Goldstein S, 2004, J AUTISM DEV DISORD, V34, P329, DOI 10.1023/B:JADD.0000029554.46570.68
Greene RW, 1996, J AM ACAD CHILD PSY, V35, P571, DOI 10.1097/00004583-199605000-00011
Groen WB, 2008, NEUROSCI BIOBEHAV R, V32, P1416, DOI 10.1016/j.neubiorev.2008.05.008
Groen WB, 2010, CEREB CORTEX, V20, P1937, DOI 10.1093/cercor/bhp264
HAPPE FGE, 1994, J AUTISM DEV DISORD, V24, P129, DOI 10.1007/BF02172093
Happe FGE, 1996, J CHILD PSYCHOL PSYC, V37, P873, DOI 10.1111/j.1469-7610.1996.tb01483.x
Holtmann M, 2007, PSYCHOPATHOLOGY, V40, P172, DOI 10.1159/000100007
Jolliffe T, 1997, J CHILD PSYCHOL PSYC, V38, P527, DOI 10.1111/j.1469-7610.1997.tb01539.x
Kamp-Becker I., 2011, AUTISM, DOI [10.1177/1362361311408932, DOI 10.1177/1362361311408932]
Kamp-Becker I, 2005, Z KINDER JUG-PSYCH, V33, P15, DOI 10.1024/1422-4917.33.1.15
Kanner L, 1943, NERV CHILD, V2, P217
Kauschke C, 1997, LANGUAGE OF EMOTIONS, P173
Kjellmer L., 2011, RES DEV DISABIL, V33, P172
Klin A., 2000, ASPERGER SYNDROME
Leyfer OT, 2006, J AUTISM DEV DISORD, V36, P849, DOI 10.1007/s10803-006-0123-0
Lopez B, 2003, J CHILD PSYCHOL PSYC, V44, P285, DOI 10.1111/1469-7610.00121
Lord C., 1999, AUTISM DIAGNOSTIC OB
Losh M, 2003, J AUTISM DEV DISORD, V33, P239, DOI 10.1023/A:1024446215446
Loth E, 2008, J AUTISM DEV DISORD, V38, P449, DOI 10.1007/s10803-007-0412-2
Loth E, 2010, NEUROPSYCHOLOGIA, V48, P1227, DOI 10.1016/j.neuropsychologia.2009.12.023
Luteijn EF, 2000, EUR CHILD ADOLES PSY, V9, P168
MacWhinney B., 2000, CHILDES PROJECT TOOL
Mason RA, 2008, NEUROPSYCHOLOGIA, V46, P269, DOI 10.1016/j.neuropsychologia.2007.07.018
Mayer M., 1969, FROG ARE YOU
Molloy CA, 2011, AUTISM, V15, P143, DOI 10.1177/1362361310379241
Mulligan A, 2009, J AUTISM DEV DISORD, V39, P197, DOI 10.1007/s10803-008-0621-3
Nijmeijer JS, 2010, J AM ACAD CHILD PSY, V49, P675, DOI 10.1016/j.jaac.2010.03.015
Noens ILJ, 2005, J COMMUN DISORD, V38, P123, DOI 10.1016/j.jcomdis.2004.06.002
Norbury CF, 2003, INT J LANG COMM DIS, V38, P287, DOI 10.1080/136820310000108133
Nuske HJ, 2011, INT J LANG COMM DIS, V46, P108, DOI 10.3109/13682822.2010.484847
Nyden A, 2010, RES DEV DISABIL, V31, P1659, DOI 10.1016/j.ridd.2010.04.010
Paul R, 2008, AUTISM RES, V1, P97, DOI 10.1002/aur.12
Pellicano E, 2010, DEV PSYCHOL, V46, P530, DOI 10.1037/a0018287
Pellicano E, 2006, DEV PSYCHOPATHOL, V18, P77, DOI 10.1017/S0954579406060056
Petermann F, 2008, KINDH ENTWICKL, V17, P71, DOI 10.1026/0942-5403.17.2.71
Rapport LJ, 2002, NEUROPSYCHOLOGY, V16, P102, DOI 10.1037//0894-4105.16.1.102
Renz K, 2003, J ABNORM CHILD PSYCH, V31, P93, DOI 10.1023/A:1021777417160
Rommelse NNJ, 2010, EUR CHILD ADOLES PSY, V19, P281, DOI 10.1007/s00787-010-0092-x
Rommelse NNJ, 2011, NEUROSCI BIOBEHAV R, V35, P1363, DOI 10.1016/j.neubiorev.2011.02.015
Rondan C, 2007, RES DEV DISABIL, V28, P197, DOI 10.1016/j.ridd.2006.02.007
Ruhl D, 2004, ADOS DIAGNOSTISCHE B
Ruhl D., 2006, ADI R DIAGNOSTISCHES
Rutter M., 2003, AUTISM DIAGNOSTIC IN
Santosh PJ, 2004, EUR CHILD ADOLES PSY, V13, P141, DOI 10.1007/s00787-004-0372-4
Senju A, 2009, SCIENCE, V325, P883, DOI 10.1126/science.1176170
Shamay-Tsoory SG, 2011, NEUROSCIENTIST, V17, P18, DOI 10.1177/1073858410379268
Simonoff E, 2008, J AM ACAD CHILD PSY, V47, P921, DOI 10.1097/CHI.0b013e318179964f
Sinzig J, 2008, EUR CHILD ADOLES PSY, V17, P63, DOI 10.1007/s00787-007-0637-9
Sinzig JK, 2007, FORTSCHR NEUROL PSYC, V75, P267, DOI 10.1055/s-2005-915567
Skovgaard AM, 2008, J CHILD PSYCHOL PSYC, V49, P553, DOI 10.1111/j.1469-7610.2007.01860.x
Tager-Flusberg H., 2005, HDB AUTISM PERVASIVE, P335
Tager-Flusberg H, 2007, PEDIATR CLIN N AM, V54, P469, DOI 10.1016/j.pcl.2007.02.011
TAGERFLUSBERG H, 1992, CHILD DEV, V63, P161, DOI 10.1111/j.1467-8624.1992.tb03604.x
TAGERFLUSBERG H, 1995, APPL PSYCHOLINGUIST, V16, P241, DOI 10.1017/S0142716400007281
Tager-Flusberg H, 2009, J SPEECH LANG HEAR R, V52, P643, DOI 10.1044/1092-4388(2009/08-0136)
Tager-Flusberg H, 1999, INT REV PSYCHIATR, V11, P325, DOI 10.1080/09540269974203
TANNOCK R, 1993, J ABNORM CHILD PSYCH, V21, P103, DOI 10.1007/BF00910492
Tewes U., 1999, HAMBURG WECHSLER INT
Tewes U., 1993, HAMBURG WECHSLER INT
Weiss R. H, 1998, GRUNDINTELLIGENZTEST
Wiesner D., 1991, TUESDAY
Woodbury-Smith MR, 2009, EUR CHILD ADOLES PSY, V18, P2, DOI 10.1007/s00787-008-0701-0
World Health Organisation, 1992, ICD 10 CLASS MENT BE
NR 87
TC 13
Z9 13
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0891-4222
J9 RES DEV DISABIL
JI Res. Dev. Disabil.
PD SEP-OCT
PY 2012
VL 33
IS 5
BP 1395
EP 1407
DI 10.1016/j.ridd.2012.03.007
PG 13
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA 962MO
UT WOS:000305549400008
PM 22522198
ER
PT J
AU Taylor, MA
Schreck, KA
Mulick, JA
AF Taylor, Matthew A.
Schreck, Kimberly A.
Mulick, James A.
TI Sleep disruption as a correlate to cognitive and adaptive behavior
problems in autism spectrum disorders
SO RESEARCH IN DEVELOPMENTAL DISABILITIES
LA English
DT Article
DE Autism; Sleep; Adaptive behavior; Intelligence; Sleep disorders
ID HIGH-FUNCTIONING AUTISM; SCHOOL-AGE-CHILDREN; PERVASIVE DEVELOPMENTAL
DISORDERS; ASPERGER-SYNDROME; DAYTIME BEHAVIOR; WAKE RHYTHM; PATTERNS;
ADOLESCENTS; DISTURBANCES; PRESCHOOLERS
AB Sleep problems associated with autism spectrum disorders (ASD) have been well documented, but less is known about the effects of sleep problems on day-time cognitive and adaptive performance in this population. Children diagnosed with autism or pervasive developmental disorder-not otherwise specified (PDD-NOS) (N = 335) from 1 to 10 years of age (M = 5.5 years) were evaluated for the relationships of Behavioral Evaluation of Disorders of Sleep (BEDS; Schreck, 1998) scores to measures of intelligence and adaptive behavior. Results suggested that children who slept fewer hours per night had lower overall intelligence, verbal skills, overall adaptive functioning, daily living skills, socialization skills, and motor development. Children who slept fewer hours at night with waking during the night had more communication problems. Breathing related sleep problems and fewer hours of sleep related most often to problems with perceptual tasks. The results indicate that quality of sleep - especially sleep duration - may be related to problems with day-time cognitive and adaptive functioning in children with autism and PDD-NOS. However, future research must be conducted to further understand these relationships. (C) 2012 Elsevier Ltd. All rights reserved.
C1 [Mulick, James A.] Ohio State Univ, Nationwide Childrens Hosp Dev Assessment Program, Westerville, OH 43081 USA.
RP Schreck, KA (reprint author), Penn State Harrisburg, 777 W Harrisburg Pike,W311 Olmsted Bldg, Middletown, PA 17057 USA.
EM mat5386@psu.edu; kas24@psu.edu; mulick.1@osu.edu
CR Allik H, 2006, BMC PSYCHIATRY, V6, DOI 10.1186/1471-244X-6-18
Allik H, 2006, J AUTISM DEV DISORD, V36, P585, DOI 10.1007/s10803-006-0099-9
Allik H, 2008, J AUTISM DEV DISORD, V38, P1625, DOI 10.1007/s10803-008-0543-0
Alpern G., 2000, DEV PROFILE, P2
Alpern G.D., 2007, DEV PROFILE, V3
American Academy of Sleep Medicine, 1991, INT CLASS SLEEP DIS
Baker E., 2011, INT M AUT RES
Bayley N., 2005, BAYLEY SCALES INFANT, Vthird
Blunden S, 2000, J CLIN EXP NEUROPSYC, V22, P554, DOI 10.1076/1380-3395(200010)22:5;1-9;FT554
Bruininks R. H., 1997, SCALES INDEPENDENT B
Bruni O, 2007, SLEEP, V30, P1577
Cotton S, 2006, RES DEV DISABIL, V27, P151, DOI 10.1016/j.ridd.2004.12.003
Couturier JL, 2005, J AM ACAD CHILD PSY, V44, P815, DOI 10.1097/01.chi.0000166377.22651.87
Elia M, 2000, BRAIN DEV-JPN, V22, P88, DOI 10.1016/S0387-7604(99)00119-9
Elliott C. D., 1990, DIFFERENTIAL ABILITY
Fernandez-Mendoza J, 2009, J ADOLESCENCE, V32, P1059, DOI 10.1016/j.adolescence.2009.03.005
Fredriksen K, 2004, CHILD DEV, V75, P84, DOI 10.1111/j.1467-8624.2004.00655.x
Gabriels RL, 2005, RES DEV DISABIL, V26, P169, DOI 10.1016/j.ridd.2004.05.003
Giannotti F, 2008, J AUTISM DEV DISORD, V38, P1888, DOI 10.1007/s10803-008-0584-4
Goldman SE, 2009, DEV NEUROPSYCHOL, V34, P560, DOI 10.1080/87565640903133509
Goldman SE, 2011, RES AUTISM SPECT DIS, V5, P1223, DOI 10.1016/j.rasd.2011.01.010
Goldman SE, 2012, J AUTISM DEV DISORD, V42, P531, DOI 10.1007/s10803-011-1270-5
Goodlin-Jones B, 2009, J CHILD PSYCHOL PSYC, V50, P1532, DOI 10.1111/j.1469-7610.2009.02110.x
Gruber R, 2010, SLEEP MED, V11, P289, DOI 10.1016/j.sleep.2009.09.007
Honomichl RD, 2002, J AUTISM DEV DISORD, V32, P553, DOI 10.1023/A:1021254914276
HOSHINO Y, 1984, FOLIA PSYCHIAT NEU J, V38, P45
Johnson KP, 2009, CHILD ADOL PSYCH CL, V18, P917, DOI 10.1016/j.chc.2009.04.001
Karpinski AC, 2008, SLEEP MED, V9, P418, DOI 10.1016/j.sleep.2007.06.004
Kaufman AS, 1983, KAUFMAN ASSESSMENT B
Krakowiak P, 2008, J SLEEP RES, V17, P197, DOI 10.1111/j.1365-2869.2008.00650.x
Limoges E, 2005, BRAIN, V128, P1049, DOI 10.1093/brain/awh425
Malow BA, 2006, SLEEP, V29, P1563
Malow BA, 2006, PEDIATR NEUROL, V34, P325, DOI 10.1016/j.pediatrneurol.2005.08.021
Mayes SD, 2009, RES AUTISM SPECT DIS, V3, P931, DOI 10.1016/j.rasd.2009.04.002
Miano S, 2007, SLEEP MED, V9, P64, DOI 10.1016/j.sleep.2007.01.014
MINDE K, 1994, J AM ACAD CHILD PSY, V33, P1114, DOI 10.1097/00004583-199410000-00007
Montgomery-Downs HE, 2003, CLIN PEDIATR, V42, P719, DOI 10.1177/000992280304200808
Mullen E, 1995, MULLEN SCALES EARLY
O'Brien LM, 2009, CHILD ADOL PSYCH CL, V18, P813, DOI 10.1016/j.chc.2009.04.008
Owens J, 2000, SLEEP BREATH, V4, P67, DOI 10.1055/s-2000-19814
Oyane NMF, 2005, AUTISM, V9, P83, DOI 10.1177/1362361305049031
Paavonen EJ, 2008, J AUTISM DEV DISORD, V38, P41, DOI 10.1007/s10803-007-0360-x
Paavonen EJ, 2003, J CHILD ADOL PSYCHOP, V13, P83, DOI 10.1089/104454603321666225
Patzold LM, 1998, J PAEDIATR CHILD H, V34, P528
Polimeni MA, 2005, J INTELL DISABIL RES, V49, P260, DOI 10.1111/j.1365-2788.2005.00642.x
Richdale A., 2001, SLEEP DISTURBANCE CH, P181
Richdale A, 2000, J INTELLECT DEV DIS, V25, P147
RICHDALE AL, 1995, EUR CHILD ADOLES PSY, V4, P175
Richdale AL, 2009, SLEEP MED REV, V13, P403, DOI 10.1016/j.smrv.2009.02.003
Roid G., 1997, LEITER INT PERFORMAN
Roid G. H., 1999, STOELTING BRIEF NONV
Roid G. H., 2003, STANFORD BINET INTEL
Rooney M., 2011, CLIN CASE STUDIES, V10, P133, DOI 10.1177/1534650111398123
ROSS JJ, 1965, ARCH NEUROL-CHICAGO, V12, P399
Sattler J. M., 2001, ASSESSMENT CHILDREN
Schreck K, 2010, J BEHAV HLTH MED, V1, P65
Schreck K. A., 1998, DISS ABSTR INT, V58, P3934
Schreck K. A., ADV AUTISM SLE UNPUB
Schreck K. A., 2003, J CHILD FAM STUD, V12, P349, DOI 10.1023/A:1023995912428
Schreck KA, 2004, RES DEV DISABIL, V25, P57, DOI 10.1016/j.ridd.2003.04.007
SCHRECK KA, 2005, J CHILD FAM STUD, V14, P101, DOI DOI 10.1007/S10826-005-1125-9
Schreck KA, 2000, J AUTISM DEV DISORD, V30, P127, DOI 10.1023/A:1005407622050
Segawa Masaya, 1992, Brain Dysfunction, V5, P211
Souders MC, 2009, SLEEP, V32, P1566
Sparrow S, 1984, VINELAND ADAPTIVE BE
SPSS, 2008, STAT PACK SOC SCI RE
Suratt PM, 2007, PEDIATRICS, V119, P320, DOI 10.1542/peds.2006-1969
Takase M, 1998, PSYCHIAT CLIN NEUROS, V52, P181, DOI 10.1111/j.1440-1819.1998.tb01017.x
Tani P, 2003, BMC PSYCHIATRY, V3, DOI 10.1186/1471-244X-3-12
Urschitz MS, 2003, AM J RESP CRIT CARE, V168, P464, DOI 10.1164/rccm.200212-1397OC
Wechsler D., 2003, WECHSLER INTELLIGENC
Wechsler D., 1967, WECHSLER PRIMARY PRE
Wechsler D, 1999, WECHSLER ABBREVIATED
Wechsler D, 1991, WECHSLER INTELLIGENC, V3rd
Wells K., 2009, J DEV DISABILITIES, V15, P55
Wiggs L, 2004, DEV MED CHILD NEUROL, V46, P372
Wiggs L, 1996, J INTELL DISABIL RES, V40, P518, DOI 10.1046/j.1365-2788.1996.799799.x
Williams PG, 2004, J SLEEP RES, V13, P265
Wolfson AR, 1998, CHILD DEV, V69, P875, DOI 10.1111/j.1467-8624.1998.tb06149.x
NR 79
TC 7
Z9 7
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0891-4222
J9 RES DEV DISABIL
JI Res. Dev. Disabil.
PD SEP-OCT
PY 2012
VL 33
IS 5
BP 1408
EP 1417
DI 10.1016/j.ridd.2012.03.013
PG 10
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA 962MO
UT WOS:000305549400009
PM 22522199
ER
PT J
AU Lin, PI
Chien, YL
Wu, YY
Chen, CH
Gau, SSF
Huang, YS
Liu, SK
Tsai, WC
Chiu, YN
AF Lin, Ping-I
Chien, Yi-Ling
Wu, Yu-Yu
Chen, Chia-Hsiang
Gau, Susan Shur-Fen
Huang, Yu-Shu
Liu, Shih-Kai
Tsai, Wen-Che
Chiu, Yen-Nan
TI The WNT2 gene polymorphism associated with speech delay inherent to
autism
SO RESEARCH IN DEVELOPMENTAL DISABILITIES
LA English
DT Article
DE Autism; WNT2 gene; Haplotype; Age of first phrase; Paternal age
ID PATERNAL AGE; LANGUAGE IMPAIRMENT; SUSCEPTIBILITY GENE; SPECTRUM
DISORDERS; FOXP2; POPULATION; FAMILY; COMMON; RISK; VARIANTS
AB Previous evidence suggests that language function is modulated by genetic variants on chromosome 7q31-36. However, it is unclear whether this region harbors loci that contribute to speech delay in autism. We previously reported that the WNT2 gene located on 7q31 was associated with the risk of autism. Additionally, two other genes on 7q31-36, FOXP2 and the EN2 genes are also found to play a role in language impairment. Therefore, we hypothesize that the WNT2 gene, FOXP2 gene, and EN2 gene, may act in concert to influence language development in the same population. A total of 373 individuals diagnosed with autistic disorder were recruited in the current study. We selected 6 tag single nucleotide polymorphisms (SNPs) within the WNT2 gene, 3 tag SNPs in the FOXP2, and 3 tag SNPs in the EN2 genes, to study the effect of these genes on language development. Age of first phrase was treated as a quantitative trait. We used general linear model to assess the association between speech delay and these variants. The results show that rs2896218 in the WNT2 gene was moderately significantly associated with age of first phrase (permutation p = 0.0045). A three-locus haplotype in the WNT2 gene was significantly associated with age of first phrase (permutation p = 2 x 10(-4)). Furthermore, we detected an interaction effect on age of first phrase between a SNP rs2228946 in the WNT2 gene and another SNP rs6460013 in the EN2 gene (p = 0.0012). Therefore, the WNT2 gene may play a suggestive role in language development in autistic disorder. Additionally, the WNT2 gene and EN2 gene may act in concert to influence the language development in autism. (C) 2012 Elsevier Ltd. All rights reserved.
C1 [Lin, Ping-I; Chien, Yi-Ling; Gau, Susan Shur-Fen; Tsai, Wen-Che; Chiu, Yen-Nan] Natl Taiwan Univ Hosp, Dept Psychiat, Taipei 10002, Taiwan.
[Lin, Ping-I] Univ Calif San Francisco, Autism & Neurodev Program, San Francisco, CA 94143 USA.
[Wu, Yu-Yu; Huang, Yu-Shu] Chang Gung Mem Hosp, Dept Psychiat, Kewishan, Taiwan.
[Chen, Chia-Hsiang; Gau, Susan Shur-Fen] Natl Taiwan Univ, Coll Med, Dept Psychiat, Taipei 10764, Taiwan.
[Chen, Chia-Hsiang] Natl Hlth Res Inst, Div Mental Hlth & Addict Med, Inst Populat Hlth Sci, Zhunan, Taiwan.
[Chen, Chia-Hsiang] Tzu Chi Univ, Grad Inst Human Genet, Hualien, Taiwan.
[Chen, Chia-Hsiang] Tzu Chi Univ, Inst Med Sci, Hualien, Taiwan.
[Gau, Susan Shur-Fen] Natl Taiwan Univ, Grad Inst Epidemiol & Prevent Med, Taipei 10764, Taiwan.
[Gau, Susan Shur-Fen] Natl Taiwan Univ, Grad Inst Brain & Mind Sci, Taipei 10764, Taiwan.
[Liu, Shih-Kai] Taoyuan Mental Hosp, Dept Child & Adolescent Psychiat, Dept Hlth, Tao Yuan, Taiwan.
RP Gau, SSF (reprint author), Natl Taiwan Univ Hosp, Dept Psychiat, 7 Chung Shan S Rd, Taipei 10002, Taiwan.
EM pingi.lin@gmail.com; ylchien@hotmail.com; wuhou@yahoo.com;
cchen@nhri.org.tw; gaushufe@ntu.edu.tw; hu11092@yahoo.com.tw;
sky@typc.doh.gov.tw; tsaiwenc@ntu.edu.tw; philipch@ntuh.gov.tw
RI Chen, Chia-Hsiang /E-3939-2010
CR Alarcon M, 2002, AM J HUM GENET, V70, P60, DOI 10.1086/338241
Alarcon M, 2005, MOL PSYCHIATR, V10, P747, DOI 10.1038/sj.mp.4001666
Andres C, 2002, BRAIN RES BULL, V57, P109, DOI 10.1016/S0361-9230(01)00642-6
Anney R, 2010, HUM MOL GENET, V19, P4072, DOI 10.1093/hmg/ddq307
Bradford Y, 2001, AM J MED GENET, V105, P539, DOI 10.1002/ajmg.1497
Brune CW, 2008, AM J MED GENET B, V147B, P187, DOI 10.1002/ajmg.b.30585
Cantor RM, 2007, MOL PSYCHIATR, V12, P419, DOI 10.1038/sj.mp.4001966
CHANDLEY AC, 1991, J MED GENET, V28, P217, DOI 10.1136/jmg.28.4.217
Cheh MA, 2006, BRAIN RES, V1116, P166, DOI 10.1016/j.brainres.2006.07.086
Croen LA, 2007, ARCH PEDIAT ADOL MED, V161, P334, DOI 10.1001/archpedi.161.4.334
Cuetos F, 2007, J INT NEUROPSYCH SOC, V13, P433, DOI 10.1017/S1355617707070609
De Ferrari GV, 2006, ONCOGENE, V25, P7545, DOI 10.1038/sj.onc.1210064
DeThorne LS, 2006, J SPEECH LANG HEAR R, V49, P1280, DOI 10.1044/1092-4388(2006/092)
Gau SSF, 2010, PSYCHIAT CLIN NEUROS, V64, P70, DOI 10.1111/j.1440-1819.2009.02034.x
Gong XH, 2004, AM J MED GENET B, V127B, P113, DOI 10.1002/ajmg.b.20162
Hultman C, 2010, MOL PSYCHIATR, V16, P1203
Kobayashi D, 2002, DEVELOPMENT, V129, P83
Lai CSL, 2001, NATURE, V413, P519, DOI 10.1038/35097076
Lennon PA, 2007, AM J MED GENET A, V143A, P791, DOI 10.1002/ajmg.a.31632
Li J, 2004, AM J MED GENET B, V126B, P51, DOI 10.1002/ajmg.b.20122
Ma DQ, 2009, ANN HUM GENET, V73, P263, DOI 10.1111/j.1469-1809.2009.00523.x
Malaspina Dolores, 2002, CNS Spectr, V7, P26
Malaspina D, 2008, Novartis Found Symp, V289, P196
Marui T, 2005, NEUROSCI RES, V53, P91, DOI 10.1016/j.neures.2005.05.003
Marui T, 2010, INT J NEUROPSYCHOPH, V13, P443, DOI 10.1017/S1461145709990903
Nakaoka H, 2009, J HUM GENET, V54, P615, DOI 10.1038/jhg.2009.95
Newbury DF, 2002, AM J HUM GENET, V70, P1318, DOI 10.1086/339931
Perrin MC, 2007, SCHIZOPHRENIA BULL, V33, P1270, DOI 10.1093/schbul/sbm093
Purcell S, 2007, AM J HUM GENET, V81, P559, DOI 10.1086/519795
Reichenberg A, 2006, ARCH GEN PSYCHIAT, V63, P1026, DOI 10.1001/archpsyc.63.9.1026
Sousa KM, 2010, J BIOL CHEM, V285, P7246, DOI 10.1074/jbc.M109.079822
Stromswold K, 1998, HUM BIOL, V70, P297
Thomas PD, 2003, NUCLEIC ACIDS RES, V31, P334, DOI 10.1093/nar/gkg115
Vernes SC, 2008, NEW ENGL J MED, V359, P2337, DOI 10.1056/NEJMoa0802828
Vernes SC, 2007, AM J HUM GENET, V81, P1232, DOI 10.1086/522238
Viding E, 2007, BEHAV GENET, V37, P51, DOI 10.1007/s10519-006-9105-4
Villanueva P, 2011, EUR J HUM GENET, V19, P687, DOI 10.1038/ejhg.2010.251
Walter CA, 2004, DNA REPAIR, V3, P495, DOI 10.1016/j.dnarep.2004.01.005
Wang K, 2009, NATURE, V459, P528, DOI 10.1038/nature07999
Wassink TH, 2001, AM J MED GENET, V105, P406, DOI 10.1002/ajmg.1401
Watkins KE, 2002, BRAIN, V125, P452, DOI 10.1093/brain/awf058
Wible B, 2005, BRAIN, V128, P417, DOI 10.1093/brain/awh367
Woodfield T A, 1999, J Child Health Care, V3, P35
NR 43
TC 7
Z9 7
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0891-4222
J9 RES DEV DISABIL
JI Res. Dev. Disabil.
PD SEP-OCT
PY 2012
VL 33
IS 5
BP 1533
EP 1540
DI 10.1016/j.ridd.2012.03.004
PG 8
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA 962MO
UT WOS:000305549400023
PM 22522212
ER
PT J
AU Kocovska, E
Fernell, E
Billstedt, E
Minnis, H
Gillberg, C
AF Kocovska, Eva
Fernell, Elisabeth
Billstedt, Eva
Minnis, Helen
Gillberg, Christopher
TI Vitamin D and autism: Clinical review
SO RESEARCH IN DEVELOPMENTAL DISABILITIES
LA English
DT Review
DE Autism; ASD; Vitamin D; Calcitriol; Calcidiol; Neurodevelopment; Brain;
Gene regulation
ID D DEFICIENCY; SPECTRUM DISORDERS; D-RECEPTOR; RAT-BRAIN;
NEUROPSYCHIATRIC DISORDERS; 1,25-DIHYDROXYVITAMIN D-3; HEALTH
CONSEQUENCES; CHILDREN BORN; UP-REGULATION; SERUM-LEVELS
AB Background: Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder with multiple genetic and environmental risk factors. The interplay between genetic and environmental factors has become the subject of intensified research in the last several years. Vitamin D deficiency has recently been proposed as a possible environmental risk factor for ASD.
Objective: The aim of the current paper is to systematically review the research regarding the possible connection between ASD and vitamin D, and to provide a narrative review of the literature regarding the role of vitamin D in various biological processes in order to generate hypotheses for future research.
Results: Systematic data obtained by different research groups provide some, albeit very limited, support for the possible role of vitamin D deficiency in the pathogenesis of ASD. There are two main areas of involvement of vitamin D in the human body that could potentially have direct impact on the development of ASD: (1) the brain (its homeostasis, immune system and neurodevelopment) and (2) gene regulation.
Conclusion: Vitamin D deficiency - either during pregnancy or early childhood - may be an environmental trigger for ASD in individuals genetically predisposed for the broad phenotype of autism. On the basis of the results of the present review, we argue for the recognition of this possibly important role of vitamin Din ASD, and for urgent research in the field. (C) 2012 Elsevier Ltd. All rights reserved.
C1 [Kocovska, Eva; Minnis, Helen] Univ Glasgow, Inst Hlth & Wellbeing, RHSC, Glasgow G3 8SJ, Lanark, Scotland.
[Fernell, Elisabeth; Billstedt, Eva; Gillberg, Christopher] Gillberg Neuropsychiat Ctr, SE-41119 Gothenburg, Sweden.
RP Kocovska, E (reprint author), Univ Glasgow, Inst Hlth & Wellbeing, RHSC, Caledonia House,Dalnair St,Yorkhill, Glasgow G3 8SJ, Lanark, Scotland.
EM eva.kocovska@glasgow.ac.uk
CR Alexianu ME, 1998, J NEUROSCI RES, V51, P58, DOI 10.1002/(SICI)1097-4547(19980101)51:1<58::AID-JNR6>3.0.CO;2-K
Almeras L, 2007, PROTEOMICS, V7, P769, DOI 10.1002/pmic.200600392
Bakare M. O., 2011, HYPOTHESIS, V9, P2
Barnevik-Olsson M, 2008, DEV MED CHILD NEUROL, V50, P598, DOI 10.1111/j.1469-8749.2008.03036.x
Berquist A. G, 2007, EPILEPSIA, V48, P66
Blaylock RL, 2009, CURR MED CHEM, V16, P157
Bodnar LM, 2007, J CLIN ENDOCR METAB, V92, P3517, DOI 10.1210/jc.2007-0718
Borowicz KK, 2007, EUR J PHARMACOL, V573, P111, DOI 10.1016/j.ephar.2007.07.002
Bosomworth NJ, 2011, CAN FAM PHYSICIAN, V57, P16
Bromley R. L., 2008, AM ACAD NEUROLOGY, V71, P997
Burne THJ, 2004, PHYSIOL BEHAV, V81, P651, DOI 10.1016/j.physbeh.2004.03.004
Cannell JJ, 2008, ANN OTO RHINOL LARYN, V117, P864
Cannell JJ, 2010, ACTA PAEDIATR, V99, P1128, DOI 10.1111/j.1651-2227.2010.01883.x
Cannell JJ, 2008, MED HYPOTHESES, V70, P750, DOI 10.1016/j.mehy.2007.08.016
Cannell JJ, 2008, ALTERN MED REV, V13, P6
Cantorna MT, 1996, P NATL ACAD SCI USA, V93, P7861, DOI 10.1073/pnas.93.15.7861
Cheng JB, 2004, P NATL ACAD SCI USA, V101, P7711, DOI 10.1073/pnas.0402490101
CLARK JH, 1993, JPEN-PARENTER ENTER, V17, P284, DOI 10.1177/0148607193017003284
CLEMENS TL, 1982, LANCET, V1, P74
Coleman M., 2011, AUTISMS
Cui XY, 2007, INT J DEV NEUROSCI, V25, P227, DOI 10.1016/j.ijdevneu.2007.03.006
Currenti SA, 2010, CELL MOL NEUROBIOL, V30, P161, DOI 10.1007/s10571-009-9453-8
d'Hellencourt L. C., 2003, J NEUROSCI RES, V71, P575
Dealberto MJ, 2011, ACTA PSYCHIAT SCAND, V123, P339, DOI 10.1111/j.1600-0447.2010.01662.x
Eyles D, 2011, SEMIN CELL DEV BIOL, V22, P629, DOI 10.1016/j.semcdb.2011.05.004
Eyles D. W., 2006, PSYCHOEUROENDOCRINOL, V31, P959
Eyles DW, 2005, J CHEM NEUROANAT, V29, P21, DOI 10.1016/j.jchemneu.2004.08.006
Eyles DW, 2010, ACTA PAEDIATR, V99, P645, DOI 10.1111/j.1651-2227.2010.01797.x
Krishnan AV, 2011, VITAMIN D AND CANCER, P53, DOI 10.1007/978-1-4419-7188-3_3
Fernell E, 2010, ACTA PAEDIATR, V99, P743, DOI 10.1111/j.1651-2227.2010.01755.x
Feron F, 2005, BRAIN RES BULL, V65, P141, DOI 10.1016/j.brainresbull.2004.12.007
Fiester L. F., 1959, STEROIDS
Freitag CM, 2010, EUR CHILD ADOLES PSY, V19, P169, DOI 10.1007/s00787-009-0076-x
Garcion E, 2002, TRENDS ENDOCRIN MET, V13, P100, DOI 10.1016/S1043-2760(01)00547-1
GILLBERG C, 1995, J INTELL DISABIL RES, V39, P141
Gillberg C, 1998, J AUTISM DEV DISORD, V28, P415, DOI 10.1023/A:1026004505764
GILLBERG C, 1990, ACTA PSYCHIAT SCAND, V82, P152, DOI 10.1111/j.1600-0447.1990.tb01373.x
GOODMAN R, 1995, BRIT J PSYCHIAT, V167, P362, DOI 10.1192/bjp.167.3.362
Grandjean P, 2006, LANCET, V368, P2167, DOI 10.1016/S0140-6736(06)69665-7
Grant William B, 2009, Dermatoendocrinol, V1, P223
Harms LR, 2011, BEST PRACT RES CL EN, V25, P657, DOI 10.1016/j.beem.2011.05.009
Hebert KJ, 2010, AUTISM RES, V3, P185, DOI 10.1002/aur.136
Herndon AC, 2009, J AUTISM DEV DISORD, V39, P212, DOI 10.1007/s10803-008-0606-2
Holick MF, 2005, J NUTR, V135, p2739S
Holick MF, 2011, J CLIN ENDOCR METAB, V96, P1911, DOI 10.1210/jc.2011-0385
HOLICK MF, 1995, P NATL ACAD SCI USA, V92, P3124, DOI 10.1073/pnas.92.8.3124
Hollis BW, 2007, J BONE MINER RES, V22, pV39, DOI [10.1359/jbmr.07s215, 10.1359/JBMR.07S215]
Humble MB, 2010, J STEROID BIOCHEM, V121, P467, DOI 10.1016/j.jsbmb.2010.03.013
Johnson DD, 2011, AM J PERINAT, V28, P7, DOI 10.1055/s-0030-1262505
Johnson S, 2001, MED HYPOTHESES, V56, P641, DOI 10.1054/mehy.2000.1302
Kalueff AV, 2005, BRAIN RES BULL, V67, P156, DOI 10.1016/j.brainresbull.205.06.022
Kalueff AV, 2006, NEUROSCI RES, V54, P254, DOI 10.1016/j.neures.2005.12.008
Keen DV, 2010, BRIT J PSYCHIAT, V196, P274, DOI 10.1192/bjp.bp.109.065490
Kern JK, 2006, J TOXICOL ENV HEAL B, V9, P485, DOI 10.1080/10937400600882079
Kolevzon A, 2006, AM J PSYCHIAT, V163, P1288, DOI 10.1176/appi.ajp.163.7.1288
Landau EC, 1999, J AUTISM DEV DISORD, V29, P385, DOI 10.1023/A:1023030911527
Landrigan PJ, 2010, CURR OPIN PEDIATR, V22, P219, DOI 10.1097/MOP.0b013e328336eb9a
Lawrence YA, 2010, ACTA NEUROL SCAND, V121, P99, DOI 10.1111/j.1600-0404.2009.01234.x
Lichtenstein P, 2010, AM J PSYCHIAT, V167, P1357, DOI 10.1176/appi.ajp.2010.10020223
Lindsay RL, 2006, J INTELLECT DEV DIS, V31, P204, DOI 10.1080/13668250601006924
Lundstrom S, 2012, ARCH GEN PSYCHIAT, V69, P46, DOI 10.1001/archgenpsychiatry.2011.144
McGrath J, 2001, TRENDS NEUROSCI, V24, P570, DOI 10.1016/S0166-2236(00)01949-4
Meguid NA, 2010, J ALTERN COMPLEM MED, V16, P641, DOI 10.1089/acm.2009.0349
Mehrotra P, 2010, INDIAN PEDIATR, V47, P581, DOI 10.1007/s13312-010-0131-1
Molloy CA, 2010, DEV MED CHILD NEUROL, V52, P969, DOI 10.1111/j.1469-8749.2010.03704.x
Muhle R, 2004, PEDIATRICS, V113, pE472, DOI 10.1542/peds.113.5.e472
NEVEU I, 1994, J NEUROSCI RES, V38, P214, DOI 10.1002/jnr.490380212
Noble JM, 2007, PEDIATRICS, V119, pE783, DOI 10.1542/peds.2006-1071
Nygren G., 2012, J AUTISM DEV DISORD, V42, P1498, DOI DOI 10.1007/S10803-012-1488-X
Nygren G., 2011, J AUTISM DEV DISORD, DOI [10.1007/s1083-011-1391-x, DOI 10.1007/S1083-011-1391-X]
Ramagopalan SV, 2010, GENOME RES, V20, P1352, DOI 10.1101/gr.107920.110
Sadowska J., 2011, PEDIAT WSPOLCZESNA G, V13, P155
Schreck KA, 2004, J AUTISM DEV DISORD, V34, P433, DOI 10.1023/B:JADD.0000037419.78531.86
Schwalfenberg G, 2007, CAN FAM PHYSICIAN, V53, P841
Shamberger RJ, 2011, J AM COLL NUTR, V30, P348
SIEGEL A, 1984, BRAIN RES, V298, P125, DOI 10.1016/0006-8993(84)91153-3
Sigmundsdottir Hekla, 2011, Dermatoendocrinol, V3, P187, DOI 10.4161/derm.3.3.15115
Stewart C, 2008, CHILD CARE HLTH DEV, V34, P276, DOI 10.1111/j.1365-2214.2007.00806.x
Taniura H, 2006, J NEUROSCI RES, V83, P1179, DOI 10.1002/jnr.20824
Weig S. G., 2009, J CLIN NEUROMUSCULAR, V10, P160
Zerbo O, 2011, EPIDEMIOLOGY, V22, P469, DOI 10.1097/EDE.0b013e31821d0b53
NR 81
TC 19
Z9 20
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0891-4222
J9 RES DEV DISABIL
JI Res. Dev. Disabil.
PD SEP-OCT
PY 2012
VL 33
IS 5
BP 1541
EP 1550
DI 10.1016/j.ridd.2012.02.015
PG 10
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA 962MO
UT WOS:000305549400024
PM 22522213
ER
PT J
AU Eriksson, MA
Westerlund, J
Anderlid, BM
Gillberg, C
Fernell, E
AF Eriksson, Mats Anders
Westerlund, Joakim
Anderlid, Britt Marie
Gillberg, Christopher
Fernell, Elisabeth
TI First-degree relatives of young children with autism spectrum disorders:
Some gender aspects
SO RESEARCH IN DEVELOPMENTAL DISABILITIES
LA English
DT Article
DE Autism spectrum disorders ASD; Broader phenotype; Prenatal risk factors;
Antidepressants; Caesarean section; Maternal mental health; Parental
age; Immigrant
ID PERINATAL RISK-FACTORS; COPY NUMBER VARIATION; PSYCHIATRIC-DISORDERS;
INFANTILE-AUTISM; DEVELOPMENTAL DISORDERS; COMORBIDITY; PREVALENCE;
CHILDHOOD; GENETICS; PARENTS
AB Prenatal risk factors, with special focus on gender distribution of neurodevelopmental and psychiatric conditions were analysed in first-degree relatives in a population-based group of young children with autism spectrum disorders (ASD). Multiple information sources were combined. This group was contrasted with the general population regarding data from the Swedish Medical Birth register. In the ASD group, information was also obtained at parental interviews focusing on developmental and psychiatric disorders in the family. Compared to the general population, fathers of children with ASD were older and parents more often of non-European origin. Mothers of children with ASD had an increased rate of antidepressant and psychoactive medication use, and of scheduled caesarean sections. Fathers and brothers of children with ASD had high rates of ASD including the broader phenotype. Mothers of children with ASD had high rates of depression and other psychiatric disorders. These findings, hypothetically, could reflect a different ASD phenotype and difficulties diagnosing ASD in females or be an example of the close genetic relation between ASD and other psychiatric disorders. The results suggest that, in clinical and research settings, the familial background in ASD should be reviewed with a broader approach, and not be restricted to "looking out" only for diagnoses and symptoms traditionally accepted as being part of or typical of ASD. The high rate of parents of non-European origin has been noted in many Swedish studies of ASD, but the reason for this association, remains unclear. (C) 2012 Elsevier Ltd. All rights reserved.
C1 [Eriksson, Mats Anders] Karolinska Inst, Dept Womens & Childrens Hlth, Stockholm, Sweden.
[Eriksson, Mats Anders] Karolinska Inst, Ctr Neurodev Disorders, Stockholm, Sweden.
[Westerlund, Joakim] Stockholm Univ, Dept Psychol, S-10691 Stockholm, Sweden.
[Anderlid, Britt Marie] Karolinska Inst, Dept Mol Med & Surg, Stockholm, Sweden.
[Gillberg, Christopher; Fernell, Elisabeth] Gothenburg Univ, Sahlgrenska Acad, Gillberg Neuropsychiat Ctr, Gothenburg, Sweden.
RP Eriksson, MA (reprint author), Karolinska Univ Hosp, Astrid Lindgren Childrens Hosp, Dept Neuropediat, S-17176 Stockholm, Sweden.
EM mats.a.eriksson@ki.se
CR Abrahams BS, 2008, NAT REV GENET, V9, P341, DOI 10.1038/nrg2346
Asperger H, 1944, ARCH PSYCHIAT NERVEN, V117, P76, DOI 10.1007/BF01837709
Barnevik-Olsson M, 2008, DEV MED CHILD NEUROL, V50, P598, DOI 10.1111/j.1469-8749.2008.03036.x
Baron-Cohen S, 2005, SCIENCE, V310, P819, DOI 10.1126/science.1115455
Baron-Cohen S, 2011, PLOS BIOL, V9, DOI 10.1371/journal.pbio.1001081
Betancur C, 2011, BRAIN RES, V1380, P42, DOI 10.1016/j.brainres.2010.11.078
Bolton PF, 1998, PSYCHOL MED, V28, P385, DOI 10.1017/S0033291797006004
Ching MSL, 2010, AM J MED GENET B, V153B, P937, DOI 10.1002/ajmg.b.31063
Coleman M., 2012, AUTISMS
Constantino JN, 2010, AM J PSYCHIAT, V167, P1349, DOI 10.1176/appi.ajp.2010.09101470
Constantino JN, 2006, AM J PSYCHIAT, V163, P294, DOI 10.1176/appi.ajp.163.2.294
Cook EH, 2008, NATURE, V455, P919, DOI 10.1038/nature07458
Daniels JL, 2008, PEDIATRICS, V121, pE1357, DOI 10.1542/peds.2007-2296
Dhar SU, 2010, AM J MED GENET A, V152A, P573, DOI 10.1002/ajmg.a.33253
Durand CM, 2012, MOL PSYCHIATR, V17, P71, DOI 10.1038/mp.2011.57
EISENBERG L, 1956, AM J ORTHOPSYCHIAT, V26, P556
Fernell E, 2010, RES DEV DISABIL, V31, P790, DOI 10.1016/j.ridd.2010.02.003
Fernell E, 2011, RES DEV DISABIL, V32, P2092, DOI 10.1016/j.ridd.2011.08.002
Gardener H, 2011, PEDIATRICS, V128, P344, DOI 10.1542/peds.2010-1036
Gauthier J, 2009, AM J MED GENET B, V150B, P421, DOI 10.1002/ajmg.b.30822
GILLBERG C, 1993, J INTELL DISABIL RES, V37, P343
Glasson EJ, 2004, ARCH GEN PSYCHIAT, V61, P618, DOI 10.1001/archpsyc.61.6.618
Guilmatre A, 2009, ARCH GEN PSYCHIAT, V66, P947, DOI 10.1001/archgenpsychiatry.2009.80
Herbert MR, 2011, NEW ENGL J MED, V365, P173, DOI 10.1056/NEJMcibr1104261
Hultman CM, 2011, MOL PSYCHIATR, V16, P1203, DOI 10.1038/mp.2010.121
Hultman CM, 2002, EPIDEMIOLOGY, V13, P417, DOI 10.1097/01.EDE.0000016968.14007.E6
Jamain S, 2003, NAT GENET, V34, P27, DOI 10.1038/ng1136
Keen DV, 2010, BRIT J PSYCHIAT, V196, P274, DOI 10.1192/bjp.bp.109.065490
Kim HG, 2008, AM J HUM GENET, V82, P199, DOI 10.1016/j.ajhg.2007.09.011
King BH, 2011, BRAIN RES, V1380, P34, DOI 10.1016/j.brainres.2010.11.031
Larsson HJ, 2005, AM J EPIDEMIOL, V161, P916, DOI 10.1093/aje/kwi123
Lauritsen MB, 2005, J CHILD PSYCHOL PSYC, V46, P963, DOI 10.1111/j.1469-7610.2004.00391.x
Lichtenstein P, 2010, AM J PSYCHIAT, V167, P1357, DOI 10.1176/appi.ajp.2010.10020223
Lugnegard T, 2011, RES DEV DISABIL, V32, P1910, DOI 10.1016/j.ridd.2011.03.025
Lugnegard T., 2011, COMPREHENSIVE PSYCHI
Lundstrom S, 2010, J CHILD PSYCHOL PSYC, V51, P850, DOI 10.1111/j.1469-7610.2010.02223.x
Maimburg RD, 2006, ACTA PSYCHIAT SCAND, V114, P257, DOI 10.1111/j.1600-0447.2006.00805.x
Morrow EM, 2010, J AM ACAD CHILD PSY, V49, P1091, DOI 10.1016/j.jaac.2010.08.009
Munesue T, 2008, J AFFECT DISORDERS, V111, P170, DOI 10.1016/j.jad.2008.02.015
Murphy M, 2000, PSYCHOL MED, V30, P1411, DOI 10.1017/S0033291799002949
Parner ET, 2012, ANN EPIDEMIOL, V22, P143, DOI 10.1016/j.annepidem.2011.12.006
Persico AM, 2006, TRENDS NEUROSCI, V29, P349, DOI 10.1016/j.tins.2006.05.010
Pinto D, 2010, NATURE, V466, P368, DOI 10.1038/nature09146
Piven J, 1999, AM J PSYCHIAT, V156, P557
PIVEN J, 1991, J AM ACAD CHILD PSY, V30, P471, DOI 10.1097/00004583-199105000-00019
Rommelse NNJ, 2010, EUR CHILD ADOLES PSY, V19, P281, DOI 10.1007/s00787-010-0092-x
Ropers HH, 2010, ANNU REV GENOM HUM G, V11, P161, DOI 10.1146/annurev-genom-082509-141640
Sebat J, 2007, SCIENCE, V316, P445, DOI 10.1126/science.1138659
Sebat J, 2009, TRENDS GENET, V25, P528, DOI 10.1016/j.tig.2009.10.004
Shen YP, 2010, PEDIATRICS, V125, pE727, DOI 10.1542/peds.2009-1684
Simonoff E, 2008, J AM ACAD CHILD PSY, V47, P921, DOI 10.1097/CHI.0b013e318179964f
Toro R, 2010, TRENDS GENET, V26, P363, DOI 10.1016/j.tig.2010.05.007
Williams NM, 2010, LANCET, V376, P1401, DOI 10.1016/S0140-6736(10)61109-9
Yirmiya N, 2005, J CHILD PSYCHOL PSYC, V46, P69, DOI 10.1111/j.1469-7610.2004.00334.x
Zhao X, 2007, P NATL ACAD SCI USA, V104, P12831, DOI 10.1073/pnas.0705803104
NR 55
TC 5
Z9 6
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0891-4222
J9 RES DEV DISABIL
JI Res. Dev. Disabil.
PD SEP-OCT
PY 2012
VL 33
IS 5
BP 1642
EP 1648
DI 10.1016/j.ridd.2012.03.025
PG 7
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA 962MO
UT WOS:000305549400035
PM 22554810
ER
PT J
AU van der Meer, L
Kagohara, D
Achmadi, D
O'Reilly, MF
Lancioni, GE
Sutherland, D
Sigafoos, J
AF van der Meer, Larah
Kagohara, Debora
Achmadi, Donna
O'Reilly, Mark F.
Lancioni, Giulio E.
Sutherland, Dean
Sigafoos, Jeff
TI Speech-generating devices versus manual signing for children with
developmental disabilities
SO RESEARCH IN DEVELOPMENTAL DISABILITIES
LA English
DT Article
DE Augmentative and alternative communication; Communication intervention;
Developmental disability; Manual signing; Preference assessment;
Speech-generating device
ID OF-THE-LITERATURE; ALTERNATIVE COMMUNICATION; INTELLECTUAL DISABILITIES;
PICTURE EXCHANGE; PREFERENCE; STUDENTS; AUTISM; INTERVENTIONS;
ACQUISITION; INDIVIDUALS
AB We compared speed of acquisition and preference for using as speech-generating device (SGD) versus manual signing (MS) as augmentative and alternative communication (AAC) options. Four children with developmental disabilities (DD), aged 5-10 years, were taught to request preferred objects using an iPod (R)-based SGD and MS. Intervention was introduced in a multiple-probe across participants design and SGD and MS conditions were compared in an alternating treatments design. A systematic choice-making paradigm was implemented to determine if the children showed a preference for using SGD or MS. All participants showed increased use of SGD when intervention was introduced, but only three learned under the MS condition. Three participants exhibited a preference for the SGD while the remaining participant demonstrated a preference for using MS. Results support previous studies showing that individuals with DD often show a preference for different AAC options and extend previous data by suggesting that acquisition and maintenance was better for the preferred option. (C) 2012 Elsevier Ltd. All rights reserved.
C1 [van der Meer, Larah] Victoria Univ Wellington, Sch Educ Psychol & Pedag, Wellington 6147, New Zealand.
[O'Reilly, Mark F.] Univ Texas Austin, Meadows Ctr Prevent Educ Risk, Austin, TX 78712 USA.
[Lancioni, Giulio E.] Univ Bari, I-70121 Bari, Italy.
[Sutherland, Dean] Univ Canterbury, Christchurch 1, New Zealand.
RP van der Meer, L (reprint author), Victoria Univ Wellington, Sch Educ Psychol & Pedag, POB 17-310, Wellington 6147, New Zealand.
EM larah.vandermeer@vuw.ac.nz
CR Adkins T., 2001, BEHAV ANAL TODAY, V2, P259
Beck AR, 2008, EDUC TRAIN DEV DISAB, V43, P198
Beukelman D., 2005, AUGMENTATIVE ALTERNA, V3rd
Blischak DM, 2001, FOCUS AUTISM OTHER D, V16, P170, DOI 10.1177/108835760101600305
Bock S., 2005, EDUC TRAIN DEV DISAB, V40, P268
Bondy A, 2001, BEHAV MODIF, V25, P725, DOI 10.1177/0145445501255004
Bowker A., 2009, PERSPECTIVES AUGMENT, V18, P137, DOI DOI 10.1044/AAC18.4.137
Cannella-Malone HI, 2009, AUGMENT ALTERN COMM, V25, P262, DOI 10.3109/07434610903384511
DeLeon IG, 1996, J APPL BEHAV ANAL, V29, P519, DOI 10.1901/jaba.1996.29-519
Duker P. C., 2004, ONE TO ONE TRAINING
Goldstein H, 2002, J AUTISM DEV DISORD, V32, P373, DOI 10.1023/A:1020589821992
Green V., 2008, EARLY CHILDHOOD ED I, P87
Gregory MK, 2009, J APPL BEHAV ANAL, V42, P399, DOI 10.1901/jaba.2009.42-399
Iacono T., 1993, AUGMENTATIVE ALTERNA, V9, P83, DOI DOI 10.1080/07434619312331276471
Iacono T. A., 1995, AUGMENTATIVE ALTERNA, V11, P249, DOI 10.1080/07434619512331277389
Iversen P., 2007, INFORM POINTING METH
van der Meer Larah, 2011, Journal of Special Education Technology, V26
Kagohara D. M., 2010, CLIN CASE STUDIES, V9, P328, DOI DOI 10.1177/1534650110379633
Kennedy C, 2005, SINGLE CASE DESIGNS
Lancioni GE, 2007, RES DEV DISABIL, V28, P468, DOI 10.1016/j.ridd.2006.06.003
Linscheid TR, 1999, J PEDIATR PSYCHOL, V24, P215
Makaton New Zealand/Aotearoa, 1998, SIGN ILL MAK COR VOC
Mirenda P, 2003, LANG SPEECH HEAR SER, V34, P203, DOI 10.1044/0161-1461(2003/017)
National Research Council, 2001, ED CHILDR AUT
Peeters T, 1999, AUTISM MED ED ASPECT
Ringdahl JE, 2009, RES DEV DISABIL, V30, P330, DOI 10.1016/j.ridd.2008.06.002
Rispoli MJ, 2010, DEV NEUROREHABIL, V13, P276, DOI 10.3109/17518421003636794
ROTHOLZ DA, 1989, J ASSOC PERS SEVERE, V14, P227
Schlosser R., 2008, EFFECTIVE PRACTICES, P325
Schlosser R. W., 2003, EFFICACY AUGMENTATIV, P85
Schlosser R. W., 2003, EFFICACY AUGMENTATIV
Schlosser RW, 2008, AM J SPEECH-LANG PAT, V17, P212, DOI 10.1044/1058-0360(2008/021)
Sigafoos J., 2001, FOCUS AUTISM OTHER D, V16, P152, DOI 10.1177/108835760101600303
Sigafoos J., 2008, AUSTRALASIAN J SPECI, V32, P55, DOI 10.1080/10300110701839931
Sigafoos J., 2005, TECHNOLOGY DISABILIT, V17, P1
Sigafoos J, 2009, AUGMENT ALTERN COMM, V25, P99, DOI 10.1080/07434610902739959
Sigafoos J, 2006, Pediatr Rehabil, V9, P1, DOI 10.1080/13638490500293341
Sigafoos Jeff, 1993, Australia and New Zealand Journal of Developmental Disabilities, V18, P133
Sigafoos J, 2003, EFFICACY AUGMENTATIV, P323
Sigafoos J., 2009, LANGUAGE AUTISM APPL, P109
Sigafoos J, 1998, ANTECEDENT CONTROL, P187
Son Seung-Hyun, 2006, Pediatr Rehabil, V9, P389, DOI 10.1080/13638490500519984
SOTO G, 1993, EDUC TRAIN MENT RET, V28, P169
Sparrow S., 2005, VINELAND 2 ADAPTIVE, V2nd
Stafford AM, 2002, EDUC TRAIN MENT RET, V37, P70
Tincani M., 2004, FOCUS AUTISM OTHER D, V19, P152, DOI DOI 10.1177/10883576040190030301
van der Meer L, 2011, RES DEV DISABIL, V32, P1422, DOI 10.1016/j.ridd.2011.02.003
van der Meer LAJ, 2010, DEV NEUROREHABIL, V13, P294, DOI 10.3109/17518421003671494
Wendt O., 2009, AUTISM SPECTRUM DISO, P83
Winborn-Kemmerer L, 2009, J APPL BEHAV ANAL, V42, P185, DOI 10.1901/jaba.2009.42-185
NR 50
TC 18
Z9 18
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0891-4222
J9 RES DEV DISABIL
JI Res. Dev. Disabil.
PD SEP-OCT
PY 2012
VL 33
IS 5
BP 1658
EP 1669
DI 10.1016/j.ridd.2012.04.004
PG 12
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA 962MO
UT WOS:000305549400037
PM 22554812
ER
PT J
AU Adenzato, M
Todisco, P
Ardito, RB
AF Adenzato, Mauro
Todisco, Patrizia
Ardito, Rita B.
TI Social Cognition in Anorexia Nervosa: Evidence of Preserved Theory of
Mind and Impaired Emotional Functioning
SO PLOS ONE
LA English
DT Article
ID AUTISM SPECTRUM DISORDERS; TORONTO-ALEXITHYMIA-SCALE; NORMAL
SEX-DIFFERENCES; EATING-DISORDERS; ASPERGER-SYNDROME; BULIMIA-NERVOSA;
INTERHEMISPHERIC COOPERATION; MULTIDIMENSIONAL SCALE; AMYGDALA
ACTIVATION; ACQUIRED THEORY
AB Background: The findings of the few studies that have to date investigated the way in which individuals with Anorexia Nervosa (AN) navigate their social environment are somewhat contradictory. We undertook this study to shed new light on the social-cognitive profile of patients with AN, analysing Theory of Mind and emotional functioning. Starting from previous evidence on the role of the amygdala in the neurobiology of AN and in the social cognition, we hypothesise preserved Theory of Mind and impaired emotional functioning in patients with AN.
Methodology: Thirty women diagnosed with AN and thirty-two women matched for education and age were involved in the study. Theory of Mind and emotional functioning were assessed with a set of validated experimental tasks. A measure of perceived social support was also used to test the correlations between this dimension and the social-cognitive profile of AN patients.
Principal Findings: The performance of patients with AN is significantly worse than that of healthy controls on tasks assessing emotional functioning, whereas patients' performance is comparable to that of healthy controls on the Theory of Mind task. Correlation analyses showed no relationship between scores on any of the social-cognition tasks and either age of onset or duration of illness. A correlation between social support and emotional functioning was found. This latter result seems to suggest a potential role of social support in the treatment and recovery of AN.
Conclusions: The pattern of results followed the experimental hypothesis. They may be useful to help us better understand the social-cognitive profile of patients with AN and to contribute to the development of effective interventions based on the ways in which patients with AN actually perceive their social environment.
C1 [Adenzato, Mauro; Ardito, Rita B.] Univ Turin, Ctr Cognit Sci, Dept Psychol, Turin, Italy.
[Adenzato, Mauro] Inst Neurosci, Turin, Italy.
[Todisco, Patrizia] Casa Cura Villa Margherita, Ctr Eating Disorders, Vicenza, Italy.
RP Adenzato, M (reprint author), Univ Turin, Ctr Cognit Sci, Dept Psychol, Turin, Italy.
EM rita.ardito@unito.it
RI Adenzato, Mauro/I-5127-2012
FU University of Turin
FX This work was supported by University of Turin (Ricerca scientifica
finanziata dall'Universita, "Correlati cognitivi e neurali della
cognizione sociale" and "Cognizione sociale e attaccamento in
popolazioni cliniche e non cliniche"). The funders had no role in study
design, data collection and analysis, decision to publish, or
preparation of the manuscript.
CR Adams Jr R. B., 2009, J COGNITIVE NEUROSCI, V22, P98
Adenzato M, 2006, THEOR PSYCHOL, V16, P747, DOI 10.1177/0959354306070515
Adenzato M, 2010, NEUROPSYCHOLOGIA, V48, P2, DOI 10.1016/j.neuropsychologia.2009.08.001
Adenzato M, 2006, SOC BEHAV PERSONAL, V34, P17
Adolphs R, 2001, CURR OPIN NEUROBIOL, V11, P231, DOI 10.1016/S0959-4388(00)00202-6
Adolphs R, 2003, NEUROPSYCHOLOGIA, V41, P119, DOI 10.1016/S0028-3932(02)00142-2
American Psychiatric Association, 2000, DIAGN STAT MAN MENT
Ardito RB, 2011, FRONT PSYCHOL, V2, DOI 10.3389/fpsyg.2011.00270
BAGBY RM, 1994, J PSYCHOSOM RES, V38, P23, DOI 10.1016/0022-3999(94)90005-1
BAGBY RM, 1994, J PSYCHOSOM RES, V38, P33, DOI 10.1016/0022-3999(94)90006-X
Bailey PE, 2008, AGING MENT HEALTH, V12, P499, DOI 10.1080/13607860802224243
Bara BG, 2011, FRONT HUM NEUROSCI, V5, DOI 10.3389/fnhum.2011.00007
Baron-Cohen S, 2006, BRAIN COGNITION, V61, P122, DOI 10.1016/j.bandc.2005.12.011
Baron-Cohen S, 2001, J AUTISM DEV DISORD, V31, P5, DOI 10.1023/A:1005653411471
Baron-Cohen S, 2000, NEUROSCI BIOBEHAV R, V24, P355, DOI 10.1016/S0149-7634(00)00011-7
Baron-Cohen S, 2004, J AUTISM DEV DISORD, V34, P163, DOI 10.1023/B:JADD.0000022607.19833.00
Baron-Cohen S, 2003, PHILOS T ROY SOC B, V358, P361, DOI 10.1098/rstb.2002.1206
Baron-Cohen S, 2001, J CHILD PSYCHOL PSYC, V42, P241, DOI 10.1017/S0021963001006643
Baron-Cohen S, 1999, EUR J NEUROSCI, V11, P1891, DOI 10.1046/j.1460-9568.1999.00621.x
Beck AT, 1996, J PERS ASSESS, V67, P588, DOI 10.1207/s15327752jpa6703_13
BOURKE MP, 1992, BRIT J PSYCHIAT, V161, P240, DOI 10.1192/bjp.161.2.240
Calabria M, 2009, BRAIN COGNITION, V70, P247, DOI 10.1016/j.bandc.2009.02.009
Cavallo M, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0025948
Cheng YW, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0018905
Christie R., 1970, STUDIES MACHIAVELLIA
Ciaramidaro A, 2007, NEUROPSYCHOLOGIA, V45, P3105, DOI 10.1016/j.neuropsychologia.2007.05.011
Connan F, 2003, PHYSIOL BEHAV, V79, P13, DOI 10.1016/S0031-9384(03)00101-X
Costafreda SG, 2008, BRAIN RES REV, V58, P57, DOI 10.1016/j.brainresrev.2007.10.012
DAHLEM NW, 1991, J CLIN PSYCHOL, V47, P756, DOI 10.1002/1097-4679(199111)47:6<756::AID-JCLP2270470605>3.0.CO;2-L
Davis C, 2005, PSYCHOL MED, V35, P377, DOI 10.1017/S0033291704003447
DAVIS MH, 1983, J PERS SOC PSYCHOL, V44, P113, DOI 10.1037//0022-3514.44.1.113
Tamietto M, 2007, NEUROPSYCHOLOGIA, V45, P836, DOI 10.1016/j.neuropsychologia.2006.08.012
Decety Jean, 2004, Behav Cogn Neurosci Rev, V3, P71, DOI 10.1177/1534582304267187
Decety J, 2010, DEV NEUROSCI-BASEL, V32, P257, DOI 10.1159/000317771
Di Martino A, 2009, BIOL PSYCHIAT, V65, P63, DOI 10.1016/j.biopsych.2008.09.022
Duval C, 2011, CONSCIOUS COGN, V20, P627, DOI 10.1016/j.concog.2010.10.025
Dziobek I, 2006, NEUROPSYCHOLOGIA, V44, P1891, DOI 10.1016/j.neuropsychologia.2006.02.005
Eddy KT, 2002, INT J EAT DISORDER, V31, P191, DOI 10.1002/eat.10016
Eddy KT, 2008, AM J PSYCHIAT, V165, P245, DOI 10.1176/appi.ajp.2007.07060951
Ellinson Z, 1998, LANCET, V352, P1192, DOI 10.1016/S0140-6736(05)60529-6
Enrici I, 2011, J COGNITIVE NEUROSCI, V23, P2415, DOI 10.1162/jocn.2010.21594
Friederich HC, 2012, NEUROIMAGE, V59, P1106, DOI 10.1016/j.neuroimage.2011.09.042
Frith CD, 2007, CURR BIOL, V17, pR724, DOI 10.1016/j.cub.2007.05.068
Gallagher HL, 2003, TRENDS COGN SCI, V7, P77, DOI 10.1016/S1364-6613(02)00025-6
GARNER DM, 1979, PSYCHOL MED, V9, P273
GILLBERG IC, 1995, COMPR PSYCHIAT, V36, P61, DOI 10.1016/0010-440X(95)90100-A
Giordano GD, 2001, J ENDOCRINOL INVEST, V24, P510
Guttman HA, 2000, FAM PROCESS, V39, P345, DOI 10.1111/j.1545-5300.2000.39306.x
Hallerbäck Maria Unenge, 2009, Cogn Neuropsychiatry, V14, P127, DOI 10.1080/13546800902901518
Hambrook D, 2008, EAT WEIGHT DISORD-ST, V13, P137
Hambrook D, 2008, BRIT J CLIN PSYCHOL, V47, P335, DOI 10.1348/014466507X272475
Happe F, 1999, COGNITION, V70, P211, DOI 10.1016/S0010-0277(99)00005-0
HAPPE FGE, 1994, J AUTISM DEV DISORD, V24, P129, DOI 10.1007/BF02172093
Harrison A, 2009, CLIN PSYCHOL PSYCHOT, V16, P348, DOI 10.1002/cpp.628
Harrison A, 2010, PSYCHOL MED, V40, P1887, DOI 10.1017/S0033291710000036
Harrison A, 2010, BIOL PSYCHIAT, V68, P755, DOI 10.1016/j.biopsych.2010.04.037
Hoek HW, 2006, CURR OPIN PSYCHIATR, V19, P389, DOI 10.1097/01.yco.0000228759.95237.78
Joos AAB, 2011, PSYCHIAT RES-NEUROIM, V191, P189, DOI 10.1016/j.pscychresns.2010.11.008
Keating C, 2010, NEUROSCI BIOBEHAV R, V34, P73, DOI 10.1016/j.neubiorev.2009.07.004
Kim YR, 2011, PSYCHIAT INVEST, V8, P9, DOI 10.4306/pi.2011.8.1.9
Kucharska-Pietura K, 2004, INT J EAT DISORDER, V35, P42, DOI 10.1002/eat.10219
Lee KH, 2012, SOC COGN AFFECT NEUR, V7, P521, DOI 10.1093/scan/nsp001
LESLIE AM, 1987, PSYCHOL REV, V94, P412, DOI 10.1037/0033-295X.94.4.412
Lieberman MD, 2007, ANNU REV PSYCHOL, V58, P259, DOI 10.1146/annurev.psych.58.110405.085654
Miyake Y, 2010, PSYCHIAT RES-NEUROIM, V181, P183, DOI 10.1016/j.pscychresns.2009.09.001
Miyake Y, 2010, NEUROIMAGE, V50, P1333, DOI 10.1016/j.neuroimage.2009.12.095
Moor BG, 2012, SOC COGN AFFECT NEUR, V7, P44, DOI 10.1093/scan/nsr020
Morris J, 2007, BRIT MED J, V334, P894, DOI 10.1136/bmj.39171.616840.BE
Oldershaw A, 2010, PSYCHOSOM MED, V72, P73, DOI 10.1097/PSY.0b013e3181c6c7ca
Paul LK, 2010, J NEURODEV DISORD, V2, P165, DOI 10.1007/s11689-010-9056-1
Phan KL, 2002, NEUROIMAGE, V16, P331, DOI 10.1006/nimg.2002.1087
Platek SM, 2004, COGNITIVE BRAIN RES, V19, P114, DOI 10.1016/j.cogbrainres.2003.11.014
Poletti M, 2011, BEHAV BRAIN RES, V219, P342, DOI 10.1016/j.bbr.2011.01.010
Poletti M, 2012, NEUROSCI BIOBEHAV R, V36, P2147, DOI 10.1016/j.neubiorev.2012.07.004
Pollatos O, 2008, PSYCHOSOM MED, V70, P701, DOI [10.1097/PSY.0b013e31817e41e6, 10.1097/PSY.0b013e31817c41e6]
PREMACK D, 1978, BEHAV BRAIN SCI, V1, P515
Rozenstein MH, 2011, J AFFECT DISORDERS, V134, P386, DOI 10.1016/j.jad.2011.06.009
Ruby P, 2004, J COGNITIVE NEUROSCI, V16, P988, DOI 10.1162/0898929041502661
Russell TA, 2000, AM J PSYCHIAT, V157, P2040, DOI 10.1176/appi.ajp.157.12.2040
Russell TA, 2009, PSYCHIAT RES, V168, P181, DOI 10.1016/j.psychres.2008.10.028
SCHMIDT U, 1993, COMPR PSYCHIAT, V34, P54, DOI 10.1016/0010-440X(93)90036-4
Schnell K, 2011, NEUROIMAGE, V54, P1743, DOI 10.1016/j.neuroimage.2010.08.024
Seeger G, 2002, NEUROSCI LETT, V326, P25, DOI 10.1016/S0304-3940(02)00312-9
Singer T, 2006, NEUROSCI BIOBEHAV R, V30, P855, DOI 10.1016/j.neubiorev.2006.06.011
Slessor G, 2007, PSYCHOL AGING, V22, P639, DOI 10.1037/0882-7974.22.3.639
Speranza M, 2007, J PSYCHOSOM RES, V63, P365, DOI 10.1016/j.jpsychores.2007.03.008
Spitzer R. L., 1994, STRUCTURED CLIN INTE
Stewart LH, 2012, J EXP PSYCHOL GEN, V141, P715, DOI 10.1037/a0027950
Stone VE, 2003, NEUROPSYCHOLOGIA, V41, P209, DOI 10.1016/S0028-3932(02)00151-3
Sugranyes G, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0025322
Takano A, 2001, PSYCHIAT RES-NEUROIM, V107, P45, DOI 10.1016/S0925-4927(01)00093-2
Tamietto M, 2006, EXP BRAIN RES, V171, P389, DOI 10.1007/s00221-005-0279-4
Taylor GJ, 1997, DISORDERS AFFECT REG
Tchanturia K, 2004, EUR EAT DISORD REV, V12, P361, DOI 10.1002/erv.608
Tiller JM, 1997, INT J EAT DISORDER, V21, P31
Van Overwalle F, 2009, HUM BRAIN MAPP, V30, P829, DOI 10.1002/hbm.20547
Vocks S, 2010, J PSYCHIATR RES, V45, P395
Vocks S, 2010, J PSYCHIATR NEUROSCI, V35, P163
Vollm BA, 2006, NEUROIMAGE, V29, P90, DOI 10.1016/j.neuroimage.2005.07.022
Walter H, 2004, J COGNITIVE NEUROSCI, V16, P1854, DOI 10.1162/0898929042947838
Walter H, 2009, SOC COGN AFFECT NEUR, V4, P166, DOI 10.1093/scan/nsn047
FerroLuzzi A, 1995, WHO TECH REP SER, V854, P1
Young AW, 2002, FACIAL EXPRESSIONS E
ZIMET GD, 1988, J PERS ASSESS, V52, P30, DOI 10.1207/s15327752jpa5201_2
Zonnevijlle-Bendek MJS, 2002, EUR CHILD ADOLES PSY, V11, P38
Zucker NL, 2007, PSYCHOL BULL, V133, P976, DOI 10.1037/0033-2909.133.6.976
NR 106
TC 17
Z9 17
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD AUG 31
PY 2012
VL 7
IS 8
AR e44414
DI 10.1371/journal.pone.0044414
PG 8
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 998EY
UT WOS:000308221300089
PM 22952975
ER
PT J
AU Lin, MY
Hrabovsky, A
Pedrosa, E
Wang, T
Zheng, DY
Lachman, HM
AF Lin, Mingyan
Hrabovsky, Anastasia
Pedrosa, Erika
Wang, Tao
Zheng, Deyou
Lachman, Herbert M.
TI Allele-Biased Expression in Differentiating Human Neurons: Implications
for Neuropsychiatric Disorders
SO PLOS ONE
LA English
DT Article
ID PLURIPOTENT STEM-CELLS; MONOALLELIC EXPRESSION; MOUSE-BRAIN; RNA-SEQ;
SCHIZOPHRENIA; GENE; AUTISM; SUSCEPTIBILITY; TRANSCRIPTOME; DUPLICATION
AB Stochastic processes and imprinting, along with genetic factors, lead to monoallelic or allele-biased gene expression. Stochastic monoallelic expression fine-tunes information processing in immune cells and the olfactory system, and imprinting plays an important role in development. Recent studies suggest that both stochastic events and imprinting may be more widespread than previously considered. We are interested in allele-biased gene expression occurring in the brain because parent-of-origin effects suggestive of imprinting appear to play a role in the transmission of schizophrenia (SZ) and autism spectrum disorders (ASD) in some families. In addition, allele-biased expression could help explain monozygotic (MZ) twin discordance and reduced penetrance. The ability to study allele-biased expression in human neurons has been transformed with the advent of induced pluripotent stem cell (iPSC) technology and next generation sequencing. Using transcriptome sequencing (RNA-Seq) we identified 801 genes in differentiating neurons that were expressed in an allele-biased manner. These included a number of putative SZ and ASD candidates, such as A2BP1 (RBFOX1), ERBB4, NLGN4X, NRG1, NRG3, NRXN1, and NLGN1. Overall, there was a modest enrichment for SZ and ASD candidate genes among those that showed evidence for allele-biased expression (chi-square, p = 0.02). In addition to helping explain MZ twin discordance and reduced penetrance, the capacity to group many candidate genes affecting a variety of molecular and cellular pathways under a common regulatory process - allele-biased expression - could have therapeutic implications.
C1 [Lin, Mingyan; Zheng, Deyou; Lachman, Herbert M.] Albert Einstein Coll Med, Dept Genet, Bronx, NY 10467 USA.
[Hrabovsky, Anastasia; Pedrosa, Erika; Lachman, Herbert M.] Albert Einstein Coll Med, Dept Psychiat & Behav Sci, Bronx, NY 10467 USA.
[Wang, Tao] Albert Einstein Coll Med, Dept Epidemiol & Populat Hlth, Bronx, NY 10467 USA.
[Zheng, Deyou; Lachman, Herbert M.] Albert Einstein Coll Med, Dominick Purpura Dept Neurosci, Bronx, NY 10467 USA.
[Zheng, Deyou] Albert Einstein Coll Med, Dept Neurol, Bronx, NY 10467 USA.
[Lachman, Herbert M.] Albert Einstein Coll Med, Dept Med, Bronx, NY 10467 USA.
RP Lin, MY (reprint author), Albert Einstein Coll Med, Dept Genet, Bronx, NY 10467 USA.
EM Herb.Lachman@einstein.yu.edu
FU National Institutes of Health [MH087840, MH073164]; CTSA Grant from the
National Center for Research Resources (NCRR) [UL1RR025750, KL2RR025749,
TL1RR025748]
FX This work was supported by the National Institutes of Health [MH087840
and MH073164 to HML]. This publication was also supported in part by the
CTSA Grant UL1RR025750, KL2RR025749 and TL1RR025748 from the National
Center for Research Resources (NCRR), a component of the National
Institutes of Health (NIH), and NIH roadmap for Medical Research. The
funders had no role in study design, data collection and analysis,
decision to publish, or preparation of the manuscript.
CR ALLEN MG, 1976, ARCH GEN PSYCHIAT, V33, P1476
Badcock C, 2006, J EVOLUTION BIOL, V19, P1007, DOI 10.1111/j.1420-9101.2006.01091.x
Benjamini Y, 2009, PHILOS T R SOC A, V367, P4255, DOI 10.1098/rsta.2009.0127
BERRETTINI WH, 1994, P NATL ACAD SCI USA, V91, P5918, DOI 10.1073/pnas.91.13.5918
Brennand KJ, 2011, NATURE, V473, P221, DOI 10.1038/nature09915
Bruck T, 2011, STEM CELL RES, V6, P187, DOI 10.1016/j.scr.2010.12.001
Cassidy SB, 2011, GENET MED, DOI [10.1097/GIM.0b013e31822bead0, DOI 10.1097/GIM.0B013E31822BEAD0]
Chiang CH, 2011, MOL PSYCHIATR, V16, P358, DOI 10.1038/mp.2011.13
Crespi B, 2008, BEHAV BRAIN SCI, V31, P241, DOI 10.1017/S0140525X08004214
Deep-Soboslay A, 2008, BIPOLAR DISORD, V10, P822, DOI 10.1111/j.1399-5618.2008.00607.x
Degner JF, 2009, BIOINFORMATICS, V25, P3207, DOI 10.1093/bioinformatics/btp579
Delaval K, 2004, CURR OPIN GENET DEV, V14, P188, DOI 10.1016/j.gde.2004.01.005
DeVeale B, 2012, PLOS GENET, V8, DOI 10.1371/journal.pgen.1002600
Edwards CA, 2007, BMC EVOL BIOL, V7, DOI 10.1186/1471-2148-7-157
Feng JX, 2011, J COMPUT BIOL, V18, P305, DOI 10.1089/cmb.2010.0243
FOLSTEIN S, 1977, J CHILD PSYCHOL PSYC, V18, P297, DOI 10.1111/j.1469-7610.1977.tb00443.x
Fradin D, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0012513
Francks C, 2010, MOL PSYCHIATR, V15, P319, DOI 10.1038/mp.2008.100
Gimelbrant A, 2007, SCIENCE, V318, P1136, DOI 10.1126/science.1148910
Ginsberg SD, 2006, PROG BRAIN RES, V158, P15, DOI 10.1016/S0079-6123(06)58002-1
GOTTESMAN II, 1989, ARCH GEN PSYCHIAT, V46, P867
Gregg C, 2010, SCIENCE, V329, P643, DOI 10.1126/science.1190830
Gregg C, 2010, SCIENCE, V329, P682, DOI 10.1126/science.1190831
Heap GA, 2010, HUM MOL GENET, V19, P122, DOI 10.1093/hmg/ddp473
Hill C, 1996, AM J PSYCHIAT, V153, P533
HOCHBERG Y, 1990, STAT MED, V9, P811, DOI 10.1002/sim.4780090710
Holmes R, 2006, CYTOGENET GENOME RES, V113, P122, DOI 10.1159/000090823
Huang H.S., 2011, NATURE, V481, P185, DOI DOI 10.1038/NATURE10726
Ideraabdullah FY, 2008, MUTAT RES-FUND MOL M, V647, P77, DOI 10.1016/j.mrfmmm.2008.08.008
Ingason A, 2011, AM J PSYCHIAT, V168, P408, DOI 10.1176/appi.ajp.2010.09111660
Kim DH, 2011, SEMIN CELL DEV BIOL, V22, P336, DOI 10.1016/j.semcdb.2011.02.025
Kim KP, 2007, GENOME RES, V17, P1731, DOI 10.1101/gr.6609207
Kitsiou-Tzeli S, 2010, AM J MED GENET A, V152A, P1925, DOI 10.1002/ajmg.a.33447
Kopsida E, 2011, HORM BEHAV, V59, P375, DOI 10.1016/j.yhbeh.2010.04.005
Krueger C, 2008, TRENDS GENET, V24, P257, DOI 10.1016/j.tig.2008.03.005
Kwasnicka-Crawford DA, 2007, J AUTISM DEV DISORD, V37, P694, DOI 10.1007/s10803-006-0225-8
Langmead B, 2009, GENOME BIOL, V10, DOI 10.1186/gb-2009-10-3-r25
Li H, 2009, BIOINFORMATICS, V25, P2078, DOI 10.1093/bioinformatics/btp352
Li SC, 2012, CURR STEM CELL RES T, V7, P2
Lin MY, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0023356
Magklara A, 2011, CELL, V145, P555, DOI 10.1016/j.cell.2011.03.040
Marchetto MCN, 2010, CELL, V143, P527, DOI 10.1016/j.cell.2010.10.016
Marioni JC, 2008, GENOME RES, V18, P1509, DOI 10.1101/gr.079558.108
Miyanari Y, 2012, NATURE, V483, P470, DOI 10.1038/nature10807
Mortazavi A, 2008, NAT METHODS, V5, P621, DOI 10.1038/nmeth.1226
Oudejans CBM, 2004, MOL HUM REPROD, V10, P589, DOI 10.1093/molehr/gah080
Pedrosa E, 2011, J NEUROGENET, V25, P88, DOI 10.3109/01677063.2011.597908
Pun FW, 2011, MOL PSYCHIATR, V16, P557, DOI 10.1038/mp.2010.47
Radford EJ, 2011, FEBS LETT, V585, P2059, DOI 10.1016/j.febslet.2011.05.063
Roppolo D, 2007, EMBO J, V26, P3423, DOI 10.1038/sj.emboj.7601782
Simic M, 2004, EUR CHILD ADOLES PSY, V13, P389, DOI 10.1007/s00787-004-0414-y
Smit H, 2010, BIOL PHILOS, V25, P803, DOI 10.1007/s10539-010-9195-5
Sultan M, 2008, SCIENCE, V321, P956, DOI 10.1126/science.1160342
Takahashi K, 2007, CELL, V131, P861, DOI 10.1016/j.cell.2007.11.019
Tchieu J, 2010, CELL STEM CELL, V7, P329, DOI 10.1016/j.stem.2010.06.024
Tsuang M, 2000, BIOL PSYCHIAT, V47, P210, DOI 10.1016/S0006-3223(99)00289-9
Wilkins JF, 2010, EVOLUTION, V64, P142, DOI 10.1111/j.1558-5646.2009.00826.x
Yagi T, 2008, DEV GROWTH DIFFER, V50, pS131, DOI 10.1111/j.1440-169X.2008.00991.x
NR 58
TC 17
Z9 17
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD AUG 30
PY 2012
VL 7
IS 8
AR e44017
DI 10.1371/journal.pone.0044017
PG 10
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 997ZH
UT WOS:000308206500042
PM 22952857
ER
PT J
AU Tsai, PT
Hull, C
Chu, YX
Greene-Colozzi, E
Sadowski, AR
Leech, JM
Steinberg, J
Crawley, JN
Regehr, WG
Sahin, M
AF Tsai, Peter T.
Hull, Court
Chu, YunXiang
Greene-Colozzi, Emily
Sadowski, Abbey R.
Leech, Jarrett M.
Steinberg, Jason
Crawley, Jacqueline N.
Regehr, Wade G.
Sahin, Mustafa
TI Autistic-like behaviour and cerebellar dysfunction in Purkinje cell Tsc1
mutant mice
SO NATURE
LA English
DT Article
ID TUBEROUS SCLEROSIS COMPLEX; MOUSE MODEL; ULTRASONIC VOCALIZATIONS;
BRAIN; DISORDERS; CHILDREN; SURVIVAL; MTORC1
AB Autism spectrum disorders (ASDs) are highly prevalent neurodevelopmental disorders(1), but the underlying pathogenesis remains poorly understood. Recent studies have implicated the cerebellum in these disorders, with post-mortem studies in ASD patients showing cerebellar Purkinje cell (PC) loss(2,3), and isolated cerebellar injury has been associated with a higher incidence of ASDs(4). However, the extent of cerebellar contribution to the pathogenesis of ASDs remains unclear. Tuberous sclerosis complex (TSC) is a genetic disorder with high rates of comorbid ASDs(5) that result from mutation of either TSC1 or TSC2, whose protein products dimerize and negatively regulate mammalian target of rapamycin (mTOR) signalling. TSC is an intriguing model to investigate the cerebellar contribution to the underlying pathogenesis of ASDs, as recent studies in TSC patients demonstrate cerebellar pathology(6) and correlate cerebellar pathology with increased ASD symptomatology(7,8). Functional imaging also shows that TSC patients with ASDs display hypermetabolism in deep cerebellar structures, compared to TSC patients without ASDs(9). However, the roles of Tsc1 and the sequelae of Tsc1 dysfunction in the cerebellum have not been investigated so far. Here we show that both heterozygous and homozygous loss of Tsc1 in mouse cerebellar PCs results in autistic-like behaviours, including abnormal social interaction, repetitive behaviour and vocalizations, in addition to decreased PC excitability. Treatment of mutant mice with the mTOR inhibitor, rapamycin, prevented the pathological and behavioural deficits. These findings demonstrate new roles for Tsc1 in PC function and define a molecular basis for a cerebellar contribution to cognitive disorders such as autism.
C1 [Tsai, Peter T.; Greene-Colozzi, Emily; Sadowski, Abbey R.; Leech, Jarrett M.; Steinberg, Jason; Sahin, Mustafa] Harvard Univ, Sch Med, Boston Childrens Hosp, FM Kirby Neurobiol Ctr,Dept Neurol, Boston, MA 02115 USA.
[Hull, Court; Chu, YunXiang; Regehr, Wade G.] Harvard Univ, Sch Med, Dept Neurobiol, Boston, MA 02115 USA.
[Crawley, Jacqueline N.] NIMH, Lab Behav Neurosci, Intramural Res Program, Bethesda, MD 20892 USA.
RP Sahin, M (reprint author), Harvard Univ, Sch Med, Boston Childrens Hosp, FM Kirby Neurobiol Ctr,Dept Neurol, Boston, MA 02115 USA.
EM peter.tsai@childrens.harvard.edu; mustafa.sahin@childrens.harvard.edu
FU Developmental Neurology Training grant [T32 NS007473]; American Academy
of Neurology; Nancy Lurie Marks Family Foundation; National Institutes
of Health (NIH) [R01 NS58956]; John Merck Scholars Fund; Autism Speaks;
Boston Children's Hospital Translational Research Program; Manton Center
for Orphan Disease Research; Boston Children's Hospital Intellectual and
Developmental Disabilities Research Center [P30 HD18655]; Intramural
Research Program, National Institute of Mental Health; NIH
[R01NS032405]; Simons Foundation [SFARI 232304]; Howard Hughes Medical
Institute Medical Research Fellowship
FX We thank G. Corfas, M. Fagiolini, P. Rosenberg, S. Goldman and the
Neurodevelopmental Behavioral Core of Boston Children's Hospital for
assistance with behavioural experiments. We are grateful to C. Walsh, L.
Benowitz and members of the Sahin laboratory for critical reading of the
manuscript, and to M. Gregas for advice regarding statistical analysis.
P. T. T. received support from the Developmental Neurology Training
grant (T32 NS007473), American Academy of Neurology, and the Nancy Lurie
Marks Family Foundation. This work and M. S. are supported in part by
the National Institutes of Health (NIH; grant R01 NS58956), the John
Merck Scholars Fund, Autism Speaks, the Nancy Lurie Marks Family
Foundation, Boston Children's Hospital Translational Research Program,
Manton Center for Orphan Disease Research and Boston Children's Hospital
Intellectual and Developmental Disabilities Research Center (grant P30
HD18655). J.N.C. is supported by the Intramural Research Program,
National Institute of Mental Health. W. G. R. is supported by the NIH
(grant R01NS032405) and the Simons Foundation (grant SFARI 232304).
Y.X.C. is supported by the Howard Hughes Medical Institute Medical
Research Fellowship.
CR Amaral DG, 2008, TRENDS NEUROSCI, V31, P137, DOI 10.1016/j.tins.2007.12.005
[Anonymous], 2009, MMWR SURVEILL SUMM, V58, P1
Asano E, 2001, NEUROLOGY, V57, P1269
Barski JJ, 2000, GENESIS, V28, P93, DOI 10.1002/1526-968X(200011/12)28:3/4<93::AID-GENE10>3.0.CO;2-W
Bateup HS, 2011, J NEUROSCI, V31, P8862, DOI 10.1523/JNEUROSCI.1617-11.2011
Bauman ML, 2005, INT J DEV NEUROSCI, V23, P183, DOI 10.1016/j.ijdevneu.2004.09.006
Bednar I, 2002, MOL CELL NEUROSCI, V20, P354, DOI 10.1006/mcne.2002.1112
Buitrago MM, 2004, NEUROBIOL LEARN MEM, V81, P211, DOI 10.1016/j.nlm.2004.01.001
Choi YJ, 2008, GENE DEV, V22, P2485, DOI 10.1101/gad.1685008
De Zeeuw CI, 2011, NAT REV NEUROSCI, V12, P327, DOI 10.1038/nrn3011
Di Nardo A, 2009, J NEUROSCI, V29, P5926, DOI 10.1523/JNEUROSCI.0778-09.2009
Eluvathingal TJ, 2006, J CHILD NEUROL, V21, P846, DOI 10.2310/7010.2006.00192
Ertan G, 2010, J NEURORADIOLOGY, V37, P231, DOI 10.1016/j.neurad.2009.12.006
Holmes A, 2001, BEHAV NEUROSCI, V115, P1129, DOI 10.1037//0735-7044.115.5.1129
Hull C, 2012, NEURON, V73, P149, DOI 10.1016/j.neuron.2011.10.030
Insel TR, 2004, ANNU REV NEUROSCI, V27, P697, DOI 10.1146/annurev.neuro.27.070203.144148
Jeste SS, 2008, J CHILD NEUROL, V23, P520, DOI 10.1177/0883073807309788
Kurejova M, 2010, MOL PAIN, V6, DOI 10.1186/1744-8069-6-18
Kwiatkowski DJ, 2002, HUM MOL GENET, V11, P525, DOI 10.1093/hmg/11.5.525
Limperopoulos C, 2007, PEDIATRICS, V120, P584, DOI 10.1542/peds.2007-1041
Meikle L, 2007, J NEUROSCI, V27, P5546, DOI 10.1523/JNEUROSCI.5540-06.2007
Meikle L, 2008, J NEUROSCI, V28, P5422, DOI 10.1523/JNEUROSCI.0955-08.2008
Muller RA, 2007, MENT RETARD DEV D R, V13, P85, DOI 10.1002/mrdd.20141
Nie D, 2010, NAT NEUROSCI, V13, P163, DOI 10.1038/nn.2477
Reith RM, 2011, NEUROBIOL DIS, V43, P113, DOI 10.1016/j.nbd.2011.02.014
Ryu YH, 1999, EUR J NUCL MED, V26, P253, DOI 10.1007/s002590050385
Sajdel-Sulkowska EM, 2009, CEREBELLUM, V8, P366, DOI 10.1007/s12311-009-0105-9
Scattoni ML, 2009, NEUROSCI BIOBEHAV R, V33, P508, DOI 10.1016/j.neubiorev.2008.08.003
Schmahmann JD, 2004, J NEUROPSYCH CLIN N, V16, P367, DOI 10.1176/appi.neuropsych.16.3.367
Silverman JL, 2011, BRAIN RES, V1380, P120, DOI 10.1016/j.brainres.2010.09.026
Steinlin M, 2008, CEREBELLUM, V7, P607, DOI 10.1007/s12311-008-0083-3
Tavazoie SF, 2005, NAT NEUROSCI, V8, P1727, DOI 10.1038/nn1566
Tsai P, 2011, CURR OPIN NEUROL, V24, P106, DOI 10.1097/WCO.0b013e32834451c4
Weber AM, 2000, J AUTISM DEV DISORD, V30, P511, DOI 10.1023/A:1005679108529
Yang M, 2011, CURR PROTOC NEUROSCI, DOI DOI 10.1002/0471142301.NS0826S56.:UNIT
Yang M., 2009, CURR PROTOC NEUROSCI, DOI [10.1002/0471142301.ns0824s48, DOI 10.1002/0471142301.NS0824S48]
Young DM, 2010, P NATL ACAD SCI USA, V107, P11074, DOI 10.1073/pnas.1005620107
Zhou J, 2009, J NEUROSCI, V29, P1773, DOI 10.1523/JNEUROSCI.5685-08.2009
NR 38
TC 110
Z9 112
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0028-0836
J9 NATURE
JI Nature
PD AUG 30
PY 2012
VL 488
IS 7413
BP 647
EP +
DI 10.1038/nature11310
PG 6
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 996NC
UT WOS:000308095100054
PM 22763451
ER
PT J
AU Quinn, KD
Nguyen, NQT
Wach, MM
Wood, TD
AF Quinn, Kevin D.
Nguyen, Nhu Q. T.
Wach, Michael M.
Wood, Troy D.
TI Tandem mass spectrometry of bilin tetrapyrroles by electrospray
ionization and collision-induced dissociation
SO RAPID COMMUNICATIONS IN MASS SPECTROMETRY
LA English
DT Article
ID NEONATAL JAUNDICE; UROBILIN; PIGMENTS; RESOLUTION; DISORDERS; PRODUCTS;
AUTISM
AB RATIONALE Bilins are metabolic products of hosts and bacteria on porphyrins, and are markers of health state and human waste contamination. Although bilin tandem mass spectrometry reports exist, their fragmentation behavior as a function of structure has not been compared, nor has fragmentation been examined as a function of collision energy. METHODS The fragmentation of bilins generated by positive ion mode electrospray ionization is examined by collision-induced dissociation (CID). CID on a quadrupole ion trap and on a Fourier transform ion cyclotron resonance (FT-ICR) mass spectrometer as a function of collision energy is compared. Methyl esterification was used to deduce which product ions contain the inner pyrrole rings. FT-ICR high mass accuracy measurements were used to determine the formulas of the resultant product ions. RESULTS The central carbon's bonding to the inner pyrrole rings influences fragmentation. Bilirubin is unique because fragmentation adjacent to the central methylene group between innermost rings predominates, and loss of a terminal pyrrole is observed only with helium collision gas. The other bilins lose the terminal pyrroles first; as CID energy is increased, additional fragmentation due to neutral losses of small molecules such as H2O, CO, CO2, and methanol occurs. CONCLUSIONS Based on these observations, fragmentation schemes for the bilins are proposed that are strongly dependent on the molecular structure and collision energy; only bilirubin fragmentation is influenced significantly by the collision gas used. This report should have value in identification of this class of molecules for biomarker detection. Copyright (C) 2012 John Wiley & Sons, Ltd.
C1 [Quinn, Kevin D.; Nguyen, Nhu Q. T.; Wach, Michael M.; Wood, Troy D.] SUNY Buffalo, Dept Chem, Buffalo, NY 14260 USA.
[Wood, Troy D.] SUNY Buffalo, Dept Struct Biol, Buffalo, NY 14260 USA.
[Nguyen, Nhu Q. T.] Univ Akron, Dept Chem, Akron, OH 44325 USA.
RP Wood, TD (reprint author), SUNY Buffalo, Dept Chem, Nat Sci Complex, Buffalo, NY 14260 USA.
EM twood@buffalo.edu
FU NIH through National Center for Research Resources [S10-RR029517-01]
FX We gratefully acknowledge Dr. Christopher L. Pennington and Prof. Yong
Seok Choi, who detected stercobilin present in human urine specimens
before this study was conducted. We gratefully acknowledge the financial
support of the NIH through the National Center for Research Resources
for providing the funding used to obtain the FT-ICR instrument (Grant
S10-RR029517-01).
CR Maisels MJ, 2004, PEDIATRICS, V114, P297
Amin SB, 2011, J AUTISM DEV DISORD, V41, P1455, DOI 10.1007/s10803-010-1169-6
FAHMY K, 1972, BIOCHIM BIOPHYS ACTA, V264, P85, DOI 10.1016/0304-4165(72)90119-5
Jackson A. H., 1966, NATURE, V209, P81
JACKSON AH, 1976, BIOCHEM SOC T, V4, P214
JACKSON AH, 1967, TETRAHEDRON, V23, P603, DOI 10.1016/0040-4020(67)85006-3
Jones-Lepp TL, 2006, J ENVIRON MONITOR, V8, P472, DOI 10.1039/b512858g
Maimburg RD, 2010, PEDIATRICS, V126, P872, DOI 10.1542/peds.2010-0052
Marshall AG, 2008, P NATL ACAD SCI USA, V105, P18090, DOI 10.1073/pnas.0805069105
McDonald LA, 2003, ANAL CHEM, V75, P2730, DOI 10.1021/ac0264731
Mingming M., 2007, ANAL CHEM, V79, P673
MOSCOWIT.A, 1970, BIOCHEM MED METAB B, V4, P149, DOI 10.1016/0006-2944(70)90091-8
Otani K, 2001, J SURG RES, V96, P44, DOI 10.1006/jsre.2000.6036
Pirone C, 2010, HORTSCIENCE, V45, P1411
Pirone C, 2009, J AM CHEM SOC, V131, P2830, DOI 10.1021/ja809065g
PULLMAN B, 1959, P NATL ACAD SCI USA, V45, P1476, DOI 10.1073/pnas.45.10.1476
Shi SDH, 1999, J AM SOC MASS SPECTR, V10, P1285, DOI 10.1016/S1044-0305(99)00108-7
Sleighter RL, 2007, J MASS SPECTROM, V42, P559, DOI 10.1002/jms.1221
STOLL MS, 1970, BIOCHEM J, V117, P271
Szulejko J.E., 2009, OPEN SPECTROS J, V3, P21
WATSON CJ, 1967, P NATL ACAD SCI USA, V58, P1957, DOI 10.1073/pnas.58.5.1957
Wood T. D., 2007, P 55 ASMS C MASS SPE
NR 22
TC 3
Z9 3
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0951-4198
J9 RAPID COMMUN MASS SP
JI Rapid Commun. Mass Spectrom.
PD AUG 30
PY 2012
VL 26
IS 16
BP 1767
EP 1775
DI 10.1002/rcm.6287
PG 9
WC Biochemical Research Methods; Chemistry, Analytical; Spectroscopy
SC Biochemistry & Molecular Biology; Chemistry; Spectroscopy
GA 972LY
UT WOS:000306279800006
PM 22777778
ER
PT J
AU Osborn, DPJ
Horsfall, L
Hassiotis, A
Petersen, I
Walters, K
Nazareth, I
AF Osborn, David P. J.
Horsfall, Laura
Hassiotis, Angela
Petersen, Irene
Walters, Kate
Nazareth, Irwin
TI Access to Cancer Screening in People with Learning Disabilities in the
UK: Cohort Study in the Health Improvement Network, a Primary Care
Research Database
SO PLOS ONE
LA English
DT Article
ID INTELLECTUAL DISABILITIES
AB Objectives: To assess whether people with learning disability in the UK have poorer access to cancer screening.
Design: Four cohort studies comparing people with and without learning disability, within the recommended age ranges for cancer screening in the UK. We used Poisson regression to determine relative incidence rates of cancer screening.
Setting: The Health Improvement Network, a UK primary care database with over 450 General practices.
Participants: Individuals with a recorded diagnosis of learning disability including general diagnostic terms, specific syndromes, chromosomal abnormalities and autism in their General Practitioner computerised notes. For each type of cancer screening, a comparison cohort of up to six people without learning disability was selected for each person with a learning disability, using stratified sampling on age within GP practice.
Main outcome measures: Incidence rate ratios for receiving 1) a cervical smear test, 2) a mammogram, 3) a faecal occult blood test and 4) a prostate specific antigen test.
Results: Relative rates of screening for all four cancers were significantly lower for people with learning disability. The adjusted incidence rate ratios (95% confidence intervals) were Cervical smears: Number eligible with learning disability = 6,254; IRR = 0.54 (0.52-0.56). Mammograms: Number eligible with learning disability = 2,956; IRR = 0.76 (0.72-0.81); Prostate Specific Antigen: Number eligible = 3,520; IRR = 0.87 (0.80-0.96) and Faecal Occult Blood Number eligible = 6,566; 0.86 (0.78-0.94). Differences in screening rates were less pronounced in more socially deprived areas. Disparities in cervical screening rates narrowed over time, but were 45% lower in 2008/9, those for breast cancer screening appeared to widen and were 35% lower in 2009.
Conclusion: Despite recent incentives, people with learning disability in the UK are significantly less likely to receive screening tests for cancer that those without learning disability. Other methods for reducing inequalities in access to cancer screening should be considered.
C1 [Osborn, David P. J.; Hassiotis, Angela] UCL, Mental Hlth Sci Unit, London, England.
[Horsfall, Laura; Petersen, Irene; Walters, Kate; Nazareth, Irwin] UCL, Res Dept Primary Care & Populat Hlth, London, England.
RP Osborn, DPJ (reprint author), UCL, Mental Hlth Sci Unit, London, England.
EM d.osborn@ucl.ac.uk
RI Petersen, Irene/I-2751-2012; Petersen, Irene/C-5702-2009
OI Petersen, Irene/0000-0002-0037-7524
FU National Health Service (NHS) Cancer Screening Programme on behalf of
the Department of Health for England [JP/pat/L1623]
FX The study was commissioned by the National Health Service (NHS) Cancer
Screening Programme on behalf of the Department of Health for England.
(Grant reference: JP/pat/L1623.) The funder had no role in the data
collection/extraction, data analysis, decision to publish, or
preparation of the manuscript.
CR Ali A, 2008, BRIT MED J, V336, P570, DOI 10.1136/bmj.39490.543137.80
[Anonymous], 2010, ACC HLTH CAR PEOPL L
[Anonymous], 2006, EQ TREATM CLOS GAP H
[Anonymous], 2006, CANC SCREEN SER NHS
Booth N, 1994, Health Libr Rev, V11, P177
Cooper SA, 2004, BRIT MED J, V329, P414, DOI 10.1136/bmj.329.7463.414
Dave S, 2009, PHARMACOEPIDEM DR S, V18, P704, DOI 10.1002/pds.1770
Department of Health, 2001, VAL PEOPL NEW STRAT
Disability Rights Commission, 2007, EQ TREATM CLOS GAP O
Maguire A, 2009, PHARMACOEPIDEM DR S, V18, P76, DOI 10.1002/pds.1688
Michael J., 2008, HEALTHCARE ALL INDEP
NHS Employers, DIR ENH SERV 2011 12
Osborn DPJ, 2011, SCHIZOPHR RES, V129, P104, DOI 10.1016/j.schres.2011.04.003
Raftery J, 2011, BRIT MED J, V343, DOI 10.1136/bmj.d7627
Sasieni P, 2009, BRIT MED J, V339, DOI 10.1136/bmj.b2968
Stark JR, 2009, BRIT MED J, V339, DOI 10.1136/bmj.b3601
Townsend P, 1986, INEQUALITIES HLTH NO
NR 17
TC 4
Z9 4
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD AUG 29
PY 2012
VL 7
IS 8
AR e43841
DI 10.1371/journal.pone.0043841
PG 10
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 997ZC
UT WOS:000308206000053
PM 22952783
ER
PT J
AU Durand-Zaleski, I
Scott, J
Rouillon, F
Leboyer, M
AF Durand-Zaleski, Isabelle
Scott, Jan
Rouillon, Frederic
Leboyer, Marion
TI A first national survey of knowledge, attitudes and behaviours towards
schizophrenia, bipolar disorders and autism in France
SO BMC PSYCHIATRY
LA English
DT Article
DE Mental health; Bipolar disorders; Schizophrenia; Autism; Survey; Stigma;
Discrimination; Attitudes; Behaviours
ID MENTAL-ILLNESS; SOCIAL DISTANCE; PUBLIC BELIEFS; STIGMA; PEOPLE;
DANGEROUSNESS; DEPRESSION; PREJUDICE; DISCRIMINATION; ATTRIBUTION
AB Background: In order to support evidence-based policies for reduction of stigma, a better understanding of its components: ignorance (knowledge), prejudice (attitude) and discrimination (behaviour) is necessary. This study explores public perceptions and quantifies stigma for three chronic mental disorders: autism, schizophrenia and bipolar disorders in France.
Methods: Survey of 1000 adults selected from an established market research panel. The 21-item questionnaire explored knowledge, attitudes and behaviours toward each disorder.
Results: Although 95% respondents recognized the names of each disorder fewer than 70% could report specific characteristics and only 33% considered that publically available information was adequate; most respondents identified the media as their main resource. Labeling of conditions in a negative way was frequent (61%) when referring to mental disorders in general, but fell significantly (18%) when linked to an individual with a disorder. Individuals with schizophrenia are assumed to be dangerous; 65% respondents would engage in social distancing from such an individual, versus 29% for bipolar disorders and 7% for autism (p < 0.001). In contrast to other disorders, discrimination against schizophrenia was only partly attenuated in those with familiarity with mental disorders (through personal or family illness).
Conclusion: This first population-based survey in France shows that attitudes towards bipolar disorders and autism are less prejudicial than towards schizophrenia. However, most public attitudes and behaviours towards different disorders appear to be based on assumptions rather than knowledge or evidence suggesting a generic information or anti-stigma programme is unlikely to be effective.
C1 [Durand-Zaleski, Isabelle; Leboyer, Marion] URCEco & Henri Mondor Albert Chenevier Hosp, AP HP, Dept Publ Hlth & Psychiat, F-94000 Creteil, France.
[Durand-Zaleski, Isabelle; Scott, Jan; Leboyer, Marion] Univ Paris E, Fac Med, EA 4393, F-94000 Creteil, France.
[Durand-Zaleski, Isabelle; Scott, Jan; Leboyer, Marion] UMR S 955, F-94000 Creteil, France.
[Durand-Zaleski, Isabelle; Scott, Jan; Leboyer, Marion] Fdn Cooperat Sci Hop, FondaMental Fdn, F-94000 Creteil, France.
[Scott, Jan] Newcastle Univ, Acad Psychiat, Inst Neurosci, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England.
[Rouillon, Frederic] Univ Paris 05, CMME, Hop St Anne, INSERM U 1017, F-75014 Paris, France.
[Scott, Jan; Leboyer, Marion] IMRB, INSERM, U 955, F-94000 Creteil, France.
RP Leboyer, M (reprint author), URCEco & Henri Mondor Albert Chenevier Hosp, AP HP, Dept Publ Hlth & Psychiat, 51 Ave Marechal Lattre Tassigny, F-94000 Creteil, France.
EM marion.leboyer@inserm.fr
RI Scott, Jan/F-2966-2010
FU Astra-Zeneca; BMS-Otsuka; Eli-Lilly; GSK; Janssen-Cilag; Lundbeck;
Sanofi-Aventis; Servier; Institut National de la Sante et de la
Recherche Medicale (INSERM); Fondation FondaMental (Fondation de
Cooperation Scientifique pour le developpement de la recherche et des
soins en sante mentale)
FX IDZ has acted as a speaker, consultant or investigator and received
honoraria from the following firms: Johnson & Johnson (Janssen-Cilag),
Novartis, MSD, Pasteur, Sanofi-Aventis, GSK, Astra-Zeneca, Medtronic.
JLS has acted as a speaker for, attended advisory boards or had
unrestricted educational grants from Astra-Zeneca, BMS-Otsuka,
Eli-Lilly, GSK, Janssen-Cilag, Lundbeck, Sanofi-Aventis and Servier. ML
has acted as a speaker for Servier and Astra-Zeneca. All authors read
and approved the final manuscript.This research was supported by
Institut National de la Sante et de la Recherche Medicale (INSERM) and
Fondation FondaMental (Fondation de Cooperation Scientifique pour le
developpement de la recherche et des soins en sante mentale).
CR Angermeyer MC, 2003, SOC PSYCH PSYCH EPID, V38, P526, DOI 10.1007/s00127-003-0676-6
Corrigan P, 2003, J HEALTH SOC BEHAV, V44, P162, DOI 10.2307/1519806
Corrigan PW, 2001, SCHIZOPHRENIA BULL, V27, P187
Corrigan PW, 2001, SCHIZOPHRENIA BULL, V27, P219
Corrigan PW, 2000, CLIN PSYCHOL-SCI PR, V7, P48, DOI 10.1093/clipsy/7.1.48
Corrigan PW, 2002, SCHIZOPHRENIA BULL, V28, P293
Denzin N. K., 2005, SAGE HDB QUALITATIVE
Dumesnil H, 2009, PSYCHIAT SERV, V60, P1203, DOI 10.1176/appi.ps.60.9.1203
Elbogen EB, 2009, ARCH GEN PSYCHIAT, V66, P152, DOI 10.1001/archgenpsychiatry.2008.537
Glendinning R, 2004, WELL WHAT DO YOU THI
Griffiths KM, 2006, BMC PSYCHIATRY, V6, DOI 10.1186/1471-244X-6-21
Hocking B., 2000, AUSTRALAS PSYCHIATRY, V8, P19, DOI 10.1046/j.1440-1665.2000.00239.x
Jorm AF, 2000, BRIT J PSYCHIAT, V177, P396, DOI 10.1192/bjp.177.5.396
Kelly CM, 2007, CURR OPIN PSYCHIATR, V20, P13, DOI 10.1097/YCO.0b013e3280113cf5
Link BG, 2004, SCHIZOPHRENIA BULL, V30, P511
Link BG, 1999, AM J PUBLIC HEALTH, V89, P1328, DOI 10.2105/AJPH.89.9.1328
Mak WWS, 2010, SOC SCI MED, V70, P2045, DOI 10.1016/j.socscimed.2010.02.023
Nakane Y, 2005, BMC PSYCHIATRY, V5, DOI 10.1186/1471-244X-5-33
Phelan JC, 1998, SOC PSYCH PSYCH EPID, V33, pS7, DOI 10.1007/s001270050204
Quinn N, 2010, ACTA PSYCHIAT SCAND
Read J, 2006, ACTA PSYCHIAT SCAND, V114, P303, DOI 10.1111/j.1600-0447.2006.00824.x
Rusch A, 2011, J AFFECT DI IN PRESS
Sartorius N., 2005, REDUCING STIGMA MENT
Sayce L, 2007, MENTAL HLTH POLICY P, P428
Schulze B, 2003, ACTA PSYCHIAT SCAND, V107, P142, DOI 10.1034/j.1600-0447.2003.02444.x
Thornicroft G, 2007, BRIT J PSYCHIAT, V190, P192, DOI 10.1192/bjp.bp.106.025791
Vezzoli R, 2001, EUR PSYCHIAT, V16, P451, DOI 10.1016/S0924-9338(01)00606-X
WEINER B, 1988, J PERS SOC PSYCHOL, V55, P738, DOI 10.1037/0022-3514.55.5.738
WOLFF G, 1996, BRIT J PSYCHIAT, V168, P191
Wolkenstein L, 2009, INT J SOC PSYCHIATR, V55, P124, DOI 10.1177/0020764008092410
NR 30
TC 5
Z9 5
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1471-244X
J9 BMC PSYCHIATRY
JI BMC Psychiatry
PD AUG 28
PY 2012
VL 12
AR 128
DI 10.1186/1471-244X-12-128
PG 8
WC Psychiatry
SC Psychiatry
GA 061SG
UT WOS:000312867700001
PM 22928716
ER
PT J
AU Marino, BS
Lipkin, PH
Newburger, JW
Peacock, G
Gerdes, M
Gaynor, JW
Mussatto, KA
Uzark, K
Goldberg, CS
Johnson, WH
Li, J
Smith, SE
Bellinger, DC
Mahle, WT
AF Marino, Bradley S.
Lipkin, Paul H.
Newburger, Jane W.
Peacock, Georgina
Gerdes, Marsha
Gaynor, J. William
Mussatto, Kathleen A.
Uzark, Karen
Goldberg, Caren S.
Johnson, Walter H., Jr.
Li, Jennifer
Smith, Sabrina E.
Bellinger, David C.
Mahle, William T.
CA Council Cardiovasc Dis Young
Council Cardiovasc Nursing
Stroke Council
TI Neurodevelopmental Outcomes in Children With Congenital Heart Disease:
Evaluation and Management A Scientific Statement From the American Heart
Association
SO CIRCULATION
LA English
DT Article
DE AHA Scientific Statements; cardiopulmonary bypass; heart defects,
congenital; heart diseases, follow-up studies, brain; pediatrics
ID QUALITY-OF-LIFE; HYPOTHERMIC CIRCULATORY ARREST; INFANT CARDIAC-SURGERY;
EXTRACORPOREAL MEMBRANE-OXYGENATION; ATTENTION-DEFICIT/HYPERACTIVITY
DISORDER; FLOW CARDIOPULMONARY BYPASS; AUTISM SPECTRUM DISORDERS;
VENTRICULAR SEPTAL-DEFECT; 22Q11.2 DELETION SYNDROME; APOLIPOPROTEIN-E
GENOTYPE
AB Background-The goal of this statement was to review the available literature on surveillance, screening, evaluation, and management strategies and put forward a scientific statement that would comprehensively review the literature and create recommendations to optimize neurodevelopmental outcome in the pediatric congenital heart disease (CHD) population.
Methods and Results-A writing group appointed by the American Heart Association and American Academy of Pediatrics reviewed the available literature addressing developmental disorder and disability and developmental delay in the CHD population, with specific attention given to surveillance, screening, evaluation, and management strategies. MEDLINE and Google Scholar database searches from 1966 to 2011 were performed for English-language articles cross-referencing CHD with pertinent search terms. The reference lists of identified articles were also searched. The American College of Cardiology/American Heart Association classification of recommendations and levels of evidence for practice guidelines were used. A management algorithm was devised that stratified children with CHD on the basis of established risk factors. For those deemed to be at high risk for developmental disorder or disabilities or for developmental delay, formal, periodic developmental and medical evaluations are recommended. A CHD algorithm for surveillance, screening, evaluation, reevaluation, and management of developmental disorder or disability has been constructed to serve as a supplement to the 2006 American Academy of Pediatrics statement on developmental surveillance and screening. The proposed algorithm is designed to be carried out within the context of the medical home. This scientific statement is meant for medical providers within the medical home who care for patients with CHD.
Conclusions-Children with CHD are at increased risk of developmental disorder or disabilities or developmental delay. Periodic developmental surveillance, screening, evaluation, and reevaluation throughout childhood may enhance identification of significant deficits, allowing for appropriate therapies and education to enhance later academic, behavioral, psychosocial, and adaptive functioning. (Circulation. 2012; 126: 1143-1172.)
RI gaynor, j/E-5194-2013
OI gaynor, j/0000-0001-7955-5604
CR Achenbach T., 2001, ASEBA CHILD BEHAV CH
Sia CJ, 2002, PEDIATRICS, V110, P184
Wolraich M, 2011, PEDIATRICS, V128, P1007, DOI 10.1542/peds.2011-2654
Alexander J, 2005, PEDIATRICS, V116, P1238, DOI 10.1542/peds.2005-2070
American College of Cardiology and American Heart Association, METH POL ACCAHA TASK
American Psychiatric Association, 2000, DIAGN STAT MAN MENT
Andropoulos DB, 2010, J THORAC CARDIOV SUR, V139, P543, DOI 10.1016/j.jtcvs.2009.08.022
[Anonymous], 2009, MMWR SURVEILL SUMM, V58, P1
PERRIN JM, 1993, PEDIATRICS, V92, P876
[Anonymous], 2001, PEDIATRICS, V108, P192
Antshel Kevin M, 2007, J Atten Disord, V11, P64, DOI 10.1177/1087054707299397
Antshel KM, 2007, J AUTISM DEV DISORD, V37, P1776, DOI 10.1007/s10803-006-0308-6
Atallah J, 2007, J THORAC CARDIOV SUR, V134, P772, DOI 10.1016/j.jtcvs.2007.03.007
Autism and Developmental Disabilities Monitoring Network Surveillance Year 2002 Principal Investigators, 2007, MMWR SURVEILL SUMM, V56, P12
Bagwell CL, 2001, J AM ACAD CHILD PSY, V40, P1285, DOI 10.1097/00004583-200111000-00008
Ballweg JA, 2007, PEDIATR CARDIOL, V28, P126, DOI 10.1007/s00246-006-1450-9
Barkley RA, 2006, J AM ACAD CHILD PSY, V45, P192, DOI 10.1097/01.chi.0000189134.97436.e2
Bassett AS, 2011, J PEDIATR-US, V159, P332, DOI 10.1016/j.jpeds.2011.02.039
BAUM MF, 1991, J HEART LUNG TRANSPL, V10, P848
Bearden CE, 2001, J CLIN EXP NEUROPSYC, V23, P447, DOI 10.1076/jcen.23.4.447.1228
Bellinger DC, 2008, CARDIOL YOUNG, V18, P3, DOI 10.1017/S104795110700176X
Bellinger DC, 2003, J THORAC CARDIOV SUR, V126, P1385, DOI 10.1016/S0022-5223(03)00711-6
Bellinger DC, 2011, CIRCULATION, V124, P1361, DOI 10.1161/CIRCULATIONAHA.111.026963
Bellinger DC, 2009, CARDIOL YOUNG, V19, P86, DOI 10.1017/S1047951108003454
Bellinger DC, 2003, J DEV BEHAV PEDIATR, V24, P169
BELLINGER DC, 1995, NEW ENGL J MED, V332, P549, DOI 10.1056/NEJM199503023320901
Bellinger DC, 1999, CIRCULATION, V100, P526
Birkeland AL, 2005, ACTA PAEDIATR, V94, P1495, DOI 10.1080/08035250510037272
Botto LD, 2001, PEDIATRICS, V107, pE32, DOI 10.1542/peds.107.3.e32
Brickner ME, 2000, NEW ENGL J MED, V342, P256, DOI 10.1056/NEJM200001273420407
Briggs-Gowan MJ, 2004, J PEDIATR PSYCHOL, V29, P143, DOI 10.1093/jpepsy/jsh017
Briss PA, 2000, AM J PREV MED, V18, P35, DOI 10.1016/S0749-3797(99)00119-1
Brosig Cheryl L, 2007, J Pediatr Health Care, V21, P3, DOI 10.1016/j.pedhc.2006.03.008
BRUGGE KL, 1994, NEUROLOGY, V44, P232
Brune M, 2006, NEUROSCI BIOBEHAV R, V30, P437, DOI 10.1016/j.neubiorev.2005.08.001
Bruto Venera C, 2007, Congenit Heart Dis, V2, P301, DOI 10.1111/j.1747-0803.2007.00117.x
Byrne A, 2002, BRIT J EDUC PSYCHOL, V72, P513, DOI 10.1348/00070990260377497
Casey FA, 1996, J PEDIATR PSYCHOL, V21, P335, DOI 10.1093/jpepsy/21.3.335
Cassidy J, 2009, J HEART LUNG TRANSPL, V28, P249, DOI 10.1016/j.healun.2008.11.912
Chapman CA, 1996, J CHILD NEUROL, V11, P63
Chen J, 2009, ANN THORAC SURG, V88, P823, DOI 10.1016/j.athoracsur.2009.03.030
Chinnock Richard E, 2008, J Heart Lung Transplant, V27, P1079, DOI 10.1016/j.healun.2008.07.012
Clancy RR, 2003, PEDIATRICS, V111, P592, DOI 10.1542/peds.111.3.592
Clancy RR, 2005, EPILEPSIA, V46, P84, DOI 10.1111/j.0013-9580.2005.22504.x
Clancy RR, 2001, PEDIATRICS, V108, P61, DOI 10.1542/peds.108.1.61
Cnota JF, 2011, J PEDIATR-US, V159, P761, DOI 10.1016/j.jpeds.2011.04.020
Cohen M, 2007, PSYCHOSOM MED, V69, P313, DOI 10.1097/PSY.0b013e318051542c
Coleman WL, 2009, PEDIATRICS, V124, P410, DOI 10.1542/peds.2009-1061
Conrad SA, 2005, ASAIO J, V51, P4, DOI 10.1097/01.mat.0000151922.67540.E9
Cooley WC, 2011, PEDIATRICS, V128, P182
Costello JM, 2010, PEDIATRICS, V126, pE277, DOI 10.1542/peds.2009-3640
Council on Children with Disabilities Section on Developmental Behavioral Pediatrics Bright Futures Steering Committee Medical Home Initiatives for Children with Special Needs Project Advisory Committee, 2006, PEDIATRICS, V118, P1808
Duby JC, 2006, PEDIATRICS, V118, P405, DOI 10.1542/peds.2006-1231
Daliento L, 2005, HEART, V91, P213, DOI 10.1136/hrt.2003.029280
Davis CC, 1998, J PEDIATR PSYCHOL, V23, P219, DOI 10.1093/jpepsy/23.4.219
Dawson G, 2010, PEDIATRICS, V125, pE17, DOI 10.1542/peds.2009-0958
Dearani JA, 2007, CARDIOL YOUNG, V17, P87, DOI 10.1017/S1047951107001199
DEMASO DR, 1991, J PEDIATR PSYCHOL, V16, P137, DOI 10.1093/jpepsy/16.2.137
Dent CL, 2005, J THORAC CARDIOV SUR, V130, P1523, DOI 10.1016/j.jtcvs.2005.07.051
Desai S, 1997, J PEDIATR-US, V131, P233, DOI 10.1016/S0022-3476(97)70159-8
Domi T, 2008, PEDIATRICS, V122, P1292, DOI 10.1542/peds.2007-1459
Donofrio MT, 2003, PEDIATR CARDIOL, V24, P436, DOI 10.1007/s00246-002-0404-0
Downard CD, 2003, J PEDIATR SURG, V38, P1212, DOI 10.1016/S0022-3468(03)00270-7
Drotar D, 2008, PEDIATR REV, V29, pE52, DOI 10.1542/pir.29-10-e52
Drotar D, 2008, PEDIAT DEV SCREENING
Dunbar-Masterson C, 2001, CIRCULATION S1, V104, P138
Duncan P., 2008, BRIGHT FUTURES GUIDE
DUPLESSIS AJ, 1995, ANN NEUROL, V37, P488
Ellerbeck KA, 1998, J DEV BEHAV PEDIATR, V19, P335, DOI 10.1097/00004703-199810000-00003
Elliot CD, 1990, DAS ADM SCORING MANU
Fine SE, 2005, J AUTISM DEV DISORD, V35, P461, DOI 10.1007/s10803-005-5036-9
Fligor BJ, 2005, PEDIATRICS, V115, P1519, DOI 10.1542/peds.2004-0247
Forbess JM, 2002, J THORAC CARDIOV SUR, V123, P631, DOI 10.1067/mtc.2002.119342
Forbess Joseph M., 2001, Circulation, V104, pI, DOI 10.1161/hc37t1.094816
Foy Jane Meschan, 2010, Pediatrics, V125 Suppl 3, pS109, DOI 10.1542/peds.2010-0788F
Foy JM, 2010, PEDIATRICS S3, V125, pS173
Freier MC, 2004, J HEART LUNG TRANSPL, V23, P857, DOI 10.1016/j.healun.2003.08.003
Friedberg MK, 2009, J PEDIATR-US, V155, P26, DOI 10.1016/j.jpeds.2009.01.050
Fuller S, 2009, EUR J CARDIO-THORAC, V36, P40, DOI 10.1016/j.ejcts.2009.02.047
Galli KK, 2004, J THORAC CARDIOV SUR, V127, P692, DOI 10.1016/j.jtcvs.2003.09.053
Gatzoulis MA, 2006, NAT CLIN PRACT CARD, V3, P2, DOI 10.1038/ncpcardio0382
Gaynor JW, 2006, J THORAC CARDIOV SUR, V131, P181, DOI 10.1016/j.jtcvs.2005.08.062
Gaynor JW, 2007, J THORAC CARDIOV SUR, V133, P1344, DOI 10.1016/j.jtcvs.2006.10.087
Gaynor JW, 2003, J THORAC CARDIOV SUR, V126, P1736, DOI 10.1067/S0022-5223(03)01188-7
Gaynor JW, 2005, J THORAC CARDIOV SUR, V130, P1278, DOI 10.1016/j.jtcvs.2005.02.065
Gaynor JW, 2009, PEDIATRICS, V124, P241, DOI 10.1542/peds.2008-2281
Glascoe F P, 1999, J Soc Pediatr Nurs, V4, P24, DOI 10.1111/j.1744-6155.1999.tb00077.x
GLAUSER TA, 1990, PEDIATRICS, V85, P984
Goldberg CS, 2000, J PEDIATR-US, V137, P646, DOI 10.1067/mpd.2000.108952
Gonzalez RG, 1999, RADIOLOGY, V210, P155
Goodman R, 2000, BRIT J PSYCHIAT, V177, P534, DOI 10.1192/bjp.177.6.534
Gothelf D, 2003, J CLIN PSYCHIAT, V64, P1163
Green Angela, 2004, Pediatr Nurs, V30, P280
Grossfeld PD, 2004, AM J MED GENET A, V129A, P51, DOI 10.1002/ajmg.a.30090
Gupta S, 2001, CHILD CARE HLTH DEV, V27, P335, DOI 10.1046/j.1365-2214.2001.00189.x
Hack M, 2000, JAMA-J AM MED ASSOC, V284, P1973, DOI 10.1001/jama.284.15.1973
Hamrick SEG, 2003, PEDIATRICS, V111, pE671, DOI 10.1542/peds.111.6.e671
Harter S., 1999, CONSTRUCTION SELF DE
Hinton RB, 2008, PEDIATR RES, V64, P364, DOI 10.1203/PDR.0b013e3181827bf4
Hirtz D, 2000, NEUROLOGY, V55, P616
Hoffman GM, 2005, J THORAC CARDIOV SUR, V130, P1094, DOI 10.1016/j.jtcvs.2005.06.029
Hoffman JIE, 2002, J AM COLL CARDIOL, V39, P1890, DOI 10.1016/S0735-1097(02)01886-7
Holm I, 2007, ARCH PEDIAT ADOL MED, V161, P945, DOI 10.1001/archpedi.161.10.945
HOOK EB, 1983, HUM GENET, V64, P24, DOI 10.1007/BF00289473
Hovels-Gurich HH, 2007, PEDIATR CARDIOL, V28, P346, DOI 10.1007/s00246-006-0123-z
Hovels-Gurich HH, 2007, ANN THORAC SURG, V83, P1425, DOI 10.1016/j.athoracsur.2006.10.069
Hovels-Gurich HH, 2002, J THORAC CARDIOV SUR, V124, P448, DOI 10.1067/mtc.2002.122307
Hovels-Gurich HH, 2006, ANN THORAC SURG, V81, P958, DOI 10.1016/j.athoracsur.2005.09.010
Hovels-Gurich HH, 2002, ARCH DIS CHILD, V87, P506, DOI 10.1136/adc.87.6.506
Hovels-Gurich HH, 2008, EUR J PAEDIATR NEURO, V12, P378, DOI 10.1016/j.ejpn.2007.10.004
Hultman CM, 2002, EPIDEMIOLOGY, V13, P417, DOI 10.1097/01.EDE.0000016968.14007.E6
Hunter DJ, 2005, NAT REV GENET, V6, P287, DOI 10.1038/nrg1578
Imamura M, 2009, ANN THORAC SURG, V87, P1894, DOI 10.1016/j.athoracsur.2009.03.049
Jacobs JP, 2009, CARDIOL YOUNG, V19, P360, DOI 10.1017/S1047951109990151
Janus M, 1997, J PAEDIATR CHILD H, V33, P219, DOI 10.1111/j.1440-1754.1997.tb01583.x
Jarvik GP, 1997, ANN EPIDEMIOL, V7, P357, DOI 10.1016/S1047-2797(97)00028-8
JELLINEK M, 1979, J PEDIATR-US, V94, P156, DOI 10.1016/S0022-3476(79)80386-8
Johnson CP, 2007, PEDIATRICS, V120, P1183, DOI 10.1542/peds.2007-2361
Jouannic JM, 2002, ULTRASOUND OBST GYN, V20, P122, DOI 10.1046/j.1469-0705.2002.00756.x
Kalia JL, 2009, PEDIATRICS, V123, P804, DOI 10.1542/peds.2008-0928
Kaltman JR, 2005, ULTRASOUND OBST GYN, V25, P32, DOI 10.1002/uog.1785
Kaltman JR, 2006, J THORAC CARDIOV SUR, V131, P792, DOI 10.1016/j.jtcvs.2005.12.023
Kamphuis M, 2002, HEART, V87, P356, DOI 10.1136/heart.87.4.356
Kamphuis M, 2004, QUAL LIFE RES, V13, P735, DOI 10.1023/B:QURE.0000021690.84029.a3
Kamphuis M, 2002, ARCH PEDIAT ADOL MED, V156, P1143
Karsdorp PA, 2007, INT J CARDIOL, V114, P352, DOI 10.1016/j.ijcard.2006.02.004
Karsdorp PA, 2007, J PEDIATR PSYCHOL, V32, P527, DOI 10.1093/jpepsy/jsl047
Kendall L, 2001, CARDIOL YOUNG, V11, P431, DOI 10.1017/S1047951101000555
King TM, 2010, PEDIATRICS, V125, P350, DOI 10.1542/peds.2009-0388
Kirklin JK, 2010, J HEART LUNG TRANSPL, V29, P1, DOI 10.1016/j.healun.2009.10.009
Kirklin JK, 2008, J HEART LUNG TRANSPL, V27, P1065, DOI 10.1016/j.healun.2008.07.021
Kirshbom PM, 2005, J THORAC CARDIOV SUR, V129, P1091, DOI 10.1016/j.jtcvs.2004.08.013
Kovacs AH, 2005, AM HEART J, V150, P193, DOI 10.1016/j.ahj.2004.08.025
Kovacs AH, 2009, INT J CARDIOL, V137, P158, DOI 10.1016/j.ijcard.2008.06.042
KURTH CD, 1995, ANESTHESIOLOGY, V82, P74, DOI 10.1097/00000542-199501000-00011
Kurth CD, 1997, J THORAC CARDIOV SUR, V113, P71, DOI 10.1016/S0022-5223(97)70401-X
Lambert LM, 2009, PEDIATRICS, V124, pE942, DOI 10.1542/peds.2008-1697
Lane DA, 2002, HEART, V88, P71, DOI 10.1136/heart.88.1.71
Laskowitz DT, 1998, J CEREBR BLOOD F MET, V18, P465
Latal B, 2009, BMC PEDIATR, V9, DOI 10.1186/1471-2431-9-6
Lee DA, 2005, DEV MED CHILD NEUROL, V47, P35, DOI 10.1017/S00121622050006X
Li MM, 2009, J PEDIATR-US, V155, P311, DOI 10.1016/j.jpeds.2009.04.001
Licht DJ, 2004, J THORAC CARDIOV SUR, V128, P841, DOI 10.1016/j.jtcvs.2004.07.022
Licht DJ, 2009, J THORAC CARDIOV SUR, V137, P529, DOI 10.1016/j.jtcvs.2008.10.025
Limperopoulos C, 2008, NY TIMES 1026, V118, pS_908
Limperopoulos C, 2001, PEDIATRICS, V108, P1325, DOI 10.1542/peds.108.6.1325
Limperopoulos C, 2010, CIRCULATION, V121, P26, DOI 10.1161/CIRCULATIONAHA.109.865568
Limperopoulos C, 2002, J PEDIATR-US, V141, P51, DOI 10.1067/mpd.2002.125227
Limperopoulos C, 1999, PEDIATRICS, V103, P402, DOI 10.1542/peds.103.2.402
Lloyd-Jones D, 2009, CIRCULATION, V119, P480, DOI 10.1161/CIRCULATIONAHA.108.191259
Lyon ME, 2006, J ADOLESCENT HEALTH, V39, P121, DOI 10.1016/j.jadohealth.2005.09.008
Macran S, 2006, CARDIOL YOUNG, V16, P165, DOI 10.1017/S1047951106000102
Magnussen D., 1996, LIFE SPAN DEV INDIVI, P223
Mahle WT, 2001, CLIN PERINATOL, V28, P235, DOI 10.1016/S0095-5108(05)70077-4
Mahle WT, 2000, PEDIATRICS, V105, P1082, DOI 10.1542/peds.105.5.1082
Mahle W, 2002, CIRCULATION S1, V106, P109, DOI DOI 10.1161/01.CIR.000003208.33237.B1
Mahle WT, 2000, CIRCULATION, V102, P136
Majnemer A, 2006, J PEDIATR-US, V148, P72, DOI 10.1016/j.jpeds.2005.08.036
Malaisrie SC, 2008, J HEART LUNG TRANSPL, V27, P173, DOI 10.1016/j.healun.2007.11.567
Mann T, 1998, J Am Acad Audiol, V9, P367
Marino BS, 2008, QUAL LIFE RES, V17, P613, DOI 10.1007/s11136-008-9323-8
Marino BS, 2009, PEDIATRICS, V123, pE708, DOI 10.1542/peds.2008-2572
Marino BS, 2010, PEDIATRICS, V126, P498, DOI 10.1542/peds.2009-2973
Marino BS, 2011, J AM COLL CARDIOL, V57, pE421
Massaro AN, 2008, BRAIN DEV-JPN, V30, P437, DOI 10.1016/j.braindev.2007.12.013
MCCONNELL JR, 1990, AM J DIS CHILD, V144, P374
McCrindle BW, 2006, CIRCULATION, V113, P1123, DOI 10.1161/CIRCULATIONAHA.105.576660
Meijer SA, 2002, SOC SCI MED, V54, P1453, DOI 10.1016/S0277-9536(01)00127-7
Miatton M, 2007, J THORAC CARDIOV SUR, V133, P449, DOI 10.1016/j.jtcvs.2006.10.006
Miatton M, 2007, J DEV BEHAV PEDIATR, V28, P294, DOI 10.1097/DBP.0b013e3180cabc3c
Miatton M, 2007, J PEDIATR-US, V151, P73, DOI 10.1016/j.jpeds.2007.02.020
Miller SP, 2007, NEW ENGL J MED, V357, P1928, DOI 10.1056/NEJMoa067393
Moons P, 2004, ANN THORAC SURG, V77, P1359, DOI 10.1016/j.athoracsur.2003.09.073
Moons P, 2001, HEART, V86, P74, DOI 10.1136/heart.86.1.74
Morse SB, 2009, PEDIATRICS, V123, pE622, DOI 10.1542/peds.2008-1405
Moss EM, 1999, J PEDIATR-US, V134, P193, DOI 10.1016/S0022-3476(99)70415-4
Mussatto Kathleen, 2005, Cardiol Young, V15 Suppl 1, P174, DOI 10.1017/S1047951105001253
Nanba Y, 2007, PEDIATRICS, V120, pE10, DOI 10.1542/peds.2006-1844
Newburger JW, 2003, J PEDIATR-US, V143, P67, DOI 10.1016/S0022-3476(03)00183-5
NEWBURGER JW, 1993, NEW ENGL J MED, V329, P1057, DOI 10.1056/NEJM199310073291501
Niklasson L, 2009, RES DEV DISABIL, V30, P763, DOI 10.1016/j.ridd.2008.10.007
OATES RK, 1994, ACTA PAEDIATR, V83, P1303, DOI 10.1111/j.1651-2227.1994.tb13021.x
PAGON RA, 1981, J PEDIATR-US, V99, P223, DOI 10.1016/S0022-3476(81)80454-4
Paterson Sarah J, 2007, Curr Psychiatry Rep, V9, P165
Peddy SB, 2007, CARDIOL YOUNG, V17, P116, DOI 10.1017/S1047951107001229
Perlman JM, 2001, PEDIATRICS, V108, P1339, DOI 10.1542/peds.108.6.1339
Perrin JM, 2008, PEDIATRICS, V122, P451, DOI 10.1542/peds.2008-1573
Pierpont EI, 2009, GENES BRAIN BEHAV, V8, P275, DOI 10.1111/j.1601-183X.2008.00469.x
Pierpont ME, 2007, CIRCULATION, V115, P3015, DOI 10.1161/CIRCULATIONAHA.106.183056
Rappaport LA, 1998, CIRCULATION, V97, P773
Raqbi F, 2003, DEV MED CHILD NEUROL, V45, P483, DOI 10.1017/S0012162203000896
Reller MD, 2008, J PEDIATR, V153, P807, DOI 10.1016/j.jpeds.2008.05.059
Reynolds C. R., 2004, BEHAV ASSESSMENT SYS, V2nd
Rietveld S, 2002, INT J CARDIOL, V86, P19, DOI 10.1016/S0167-5273(02)00152-3
Rockett SR, 2008, ASAIO J, V54, P479, DOI 10.1097/MAT.0b013e318184e200
Rose M, 2005, QUAL LIFE RES, V14, P35, DOI 10.1007/s11136-004-0611-7
Rosenthal GL, 1996, AM J EPIDEMIOL, V143, P1079
Sable C, 2011, CIRCULATION, V123, P1454, DOI 10.1161/CIR.0b013e3182107c56
Saliba Z, 2001, HEART, V86, P69, DOI 10.1136/heart.86.1.69
Salvin JW, 2008, PEDIATR ANESTH, V18, P1157, DOI 10.1111/j.1460-9592.2008.02795.x
Salzer-Muhar U, 2002, CLIN PEDIATR, V41, P17, DOI 10.1177/000992280204100105
Sawin KJ, 2003, PRIMARY CARE CHILD C
Schonwald A, 2009, PEDIATRICS, V123, P660, DOI 10.1542/peds.2007-2798
Shakelford J, 2006, NECTAC NOTES, V21
Shillingford AJ, 2008, PEDIATRICS, V121, pE759, DOI 10.1542/peds.2007-1066
Shillingford AJ, 2007, CARDIOL YOUNG, V17, P189, DOI 10.1017/S1047951107000248
Shillingford AJ, 2004, PEDIATR CLIN N AM, V51, P1625, DOI 10.1016/j.pcl.2004.07.007
Simko Lynn Coletta, 2005, J Cardiovasc Nurs, V20, P206
SKRANES JS, 1993, NEUROPEDIATRICS, V24, P256, DOI 10.1055/s-2008-1071553
Spijkerboer AW, 2008, INT J CARDIOL, V125, P66, DOI 10.1016/j.ijcard.2007.02.025
Spijkerboer AW, 2008, J PEDIATR SURG, V43, P534, DOI 10.1016/j.jpedsurg.2007.10.037
SPURKLAND I, 1993, ACTA PAEDIATR, V82, P71, DOI 10.1111/j.1651-2227.1993.tb12520.x
Squires J, 2002, AGES STAGES QUESTION
Strittmatter WJ, 2002, CURR OPIN LIPIDOL, V13, P119, DOI 10.1097/00041433-200204000-00002
SWILLEN A, 1993, GENET COUNSEL, V4, P7
Sznajer Y, 2007, PEDIATRICS, V119, pE1325, DOI 10.1542/peds.2006-0211
Tabbutt S, 2008, PEDIATRICS, V121, P476, DOI 10.1542/peds.2007-1282
TEMPLE CM, 1993, DEV MED CHILD NEUROL, V35, P691
Thompson Jr RJ, 1997, ADAPTATION CHRONIC C
Toren P, 2007, J PAEDIATR CHILD H, V43, P662, DOI 10.1111/j.1440-1754.2007.01183.x
U.S. Department of Health and Human Services, 2000, NASNEWSLETTER, V15, P3
UTENS EMWJ, 1993, PSYCHOL MED, V23, P415
Uzark K, 2009, J HEART LUNG TRANSPL, V28, P1306, DOI 10.1016/j.healun.2009.05.002
Uzark K, 2008, PEDIATRICS, V121, pE1060, DOI 10.1542/peds.2006-3778
Uzark K, 1998, PEDIATRICS, V101, P630, DOI 10.1542/peds.101.4.630
Uzark K, 2003, PROG PEDIATR CARDIOL, V18, P141, DOI 10.1016/S1058-9813(03)00087-0
UZARK KC, 1992, J HEART LUNG TRANSPL, V11, P1160
VANBOGAERT P, 1992, NEURORADIOLOGY, V34, P52
Van Hagen JM, 2007, GENET TEST, V11, P321, DOI 10.1089/gte.2007.0007
van Rijen EHM, 2003, EUR HEART J, V24, P673, DOI 10.1016/S0195-668X(02)00749-2
Varni JW, 2002, J BEHAV MED, V25, P175, DOI 10.1023/A:1014836921812
Varni JW, 1999, MED CARE, V37, P126, DOI 10.1097/00005650-199902000-00003
Walker RE, 2004, PEDIATR CARDIOL, V25, P40, DOI 10.1007/s00246-003-0348-z
Wallander JL, 1998, J CHILD PSYCHOL PSYC, V39, P29, DOI 10.1017/S0021963097001741
Warnes CA, 2008, NY TIMES 1026, V118, pe714
Warnes CA, 2001, J AM COLL CARDIOL, V37, P1170, DOI 10.1016/S0735-1097(01)01272-4
Warnes CA, 2005, J AM COLL CARDIOL, V46, P1, DOI 10.1016/j.jacc.2005.02.083
Warnes CA, 2008, J AM COLL CARDIOL, V52, pE1, DOI 10.1016/j.jacc.2008.10.001
Wernovsky G, 2006, CARDIOL YOUNG, V16, P92, DOI 10.1017/S1047951105002398
Wernovsky G, 2000, CIRCULATION, V102, P883
Wier ML, 2006, DEV MED CHILD NEUROL, V48, P500, DOI 10.1017/S001216220600106X
Williams DL, 2000, J THORAC CARDIOV SUR, V119, P720, DOI 10.1016/S0022-5223(00)70007-9
Williams RG, 2006, J AM COLL CARDIOL, V47, P701, DOI 10.1016/j.jacc.2005.08.074
Wilson GN, 2006, PREVENTIVE HLTH CARE
Winter RM, 2007, LONDON MED DATABASES
Wolraich ML, 2003, J PEDIATR PSYCHOL, V28, P559, DOI 10.1093/jpepsy/jsg046
Wood NS, 2000, NEW ENGL J MED, V343, P378, DOI 10.1056/NEJM200008103430601
Wray J, 2001, HEART, V85, P687, DOI 10.1136/heart.85.6.687
Wray J, 1991, ANN CARDIAC SURG, P50
Wray J, 2005, CARDIOL YOUNG, V15, P133, DOI 10.1017/S1047951105000302
Wray J, 2004, J HEART LUNG TRANSPL, V23, P1103, DOI 10.1016/j.healun.2003.08.018
Yildiz S, 2001, J Pediatr Nurs, V16, P449
Youssef N M, 1988, Matern Child Nurs J, V17, P217
Zeltser I, 2008, J THORAC CARDIOV SUR, V135, P91, DOI 10.1016/j.jtcvs.2007.04.074
NR 254
TC 83
Z9 84
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0009-7322
J9 CIRCULATION
JI Circulation
PD AUG 28
PY 2012
VL 126
IS 9
BP 1143
EP 1172
DI 10.1161/CIR.0b013e318265ee8a
PG 30
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
SC Cardiovascular System & Cardiology
GA 999ZK
UT WOS:000308355100025
PM 22851541
ER
PT J
AU Silvestri, L
Bria, A
Sacconi, L
Iannello, G
Pavone, FS
AF Silvestri, L.
Bria, A.
Sacconi, L.
Iannello, G.
Pavone, F. S.
TI Confocal light sheet microscopy: micron-scale neuroanatomy of the entire
mouse brain
SO OPTICS EXPRESS
LA English
DT Article
ID PLANE ILLUMINATION MICROSCOPY; OPTICAL SECTIONING MICROSCOPY;
STRUCTURED-ILLUMINATION; EMBRYONIC-DEVELOPMENT; INFANTILE-AUTISM;
TRANSGENIC MICE; PURKINJE-CELLS; CONTRAST; RECONSTRUCTION; RESOLUTION
AB Elucidating the neural pathways that underlie brain function is one of the greatest challenges in neuroscience. Light sheet based microscopy is a cutting edge method to map cerebral circuitry through optical sectioning of cleared mouse brains. However, the image contrast provided by this method is not sufficient to resolve and reconstruct the entire neuronal network. Here we combined the advantages of light sheet illumination and confocal slit detection to increase the image contrast in real time, with a frame rate of 10 Hz. In fact, in confocal light sheet microscopy (CLSM), the out-of-focus and scattered light is filtered out before detection, without multiple acquisitions or any post-processing of the acquired data. The background rejection capabilities of CLSM were validated in cleared mouse brains by comparison with a structured illumination approach. We show that CLSM allows reconstructing macroscopic brain volumes with sub-cellular resolution. We obtained a comprehensive map of Purkinje cells in the cerebellum of L7-GFP transgenic mice. Further, we were able to trace neuronal projections across brain of thy1-GFP-M transgenic mice. The whole-brain high-resolution fluorescence imaging assured by CLSM may represent a powerful tool to navigate the brain through neuronal pathways. Although this work is focused on brain imaging, the macro-scale high-resolution tomographies affordable with CLSM are ideally suited to explore, at micron-scale resolution, the anatomy of different specimens like murine organs, embryos or flies. (C) 2012 Optical Society of America
C1 [Silvestri, L.; Sacconi, L.; Pavone, F. S.] Univ Florence, European Lab Nonlinear Spect LENS, I-50121 Florence, Italy.
[Bria, A.; Iannello, G.] Univ Campus Biomed Rome, Integrated Res Ctr, Rome, Italy.
[Bria, A.] Univ Cassino, Dept Automat Electromagnetism Informat Engn & Ind, Cassino, Italy.
[Sacconi, L.; Pavone, F. S.] CNR, Natl Opt Inst, Rome, Italy.
[Pavone, F. S.] Univ Florence, Dept Phys, I-50121 Florence, Italy.
RP Silvestri, L (reprint author), Univ Florence, European Lab Nonlinear Spect LENS, I-50121 Florence, Italy.
EM silvestri@lens.unifi.it
RI Iannello, Giulio/G-7331-2011; Sacconi, Leonardo/B-8904-2015; pavone,
francesco/F-4945-2015
OI Iannello, Giulio/0000-0003-3864-5800;
FU European Union Seventh Framework Programme [228334]; Human Frontier
Science Program [RGP0027/2009]; Italian Ministry for Education,
University and Research; Ente Cassa di Risparmio di Firenze
FX We thank Dr. Anna Letizia Allegra Mascaro and Dr. Francesco Vanzi for
helpful discussion about the manuscript, Dr. Filippo Biamonte, Dr.
Filippo Giorgi and Dr. Claudia Laperchia for assistance in perfusions,
Mr. Riccardo Ballerini for mechanical assistance, Prof. Flavio Keller
for providing us with L7-GFP mice. The research leading to these results
has received funding from the European Union Seventh Framework Programme
(FP7/2007-2013) under grant agreement n. 228334. This research project
has been also supported by Human Frontier Science Program research grant
(RGP0027/2009), and by the Italian Ministry for Education, University
and Research in the framework of the Flagship Project NANOMAX. This
research has been carried out in the framework of the research
activities of ICON foundation supported by "Ente Cassa di Risparmio di
Firenze".
CR ALTMAN J, 1985, J COMP NEUROL, V231, P42, DOI 10.1002/cne.902310105
Arrenberg AB, 2010, SCIENCE, V330, P971, DOI 10.1126/science.1195929
BAUMAN M, 1985, NEUROLOGY, V35, P866
Becker K, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0033916
Bex PJ, 2002, J OPT SOC AM A, V19, P1096, DOI 10.1364/JOSAA.19.001096
Booth MJ, 2001, J BIOMED OPT, V6, P266, DOI 10.1117/1.1382808
Bria A., 2012, IEEE INT S BIOM IM I
Briggman KL, 2011, NATURE, V471, P183, DOI 10.1038/nature09818
Buss RR, 2006, ANNU REV NEUROSCI, V29, P1, DOI 10.1146/annurev.neuro.29.051605.112800
Buytaert JAN, 2007, J BIOMED OPT, V12, DOI 10.1117/1.2671712
Conchello JA, 2005, NAT METHODS, V2, P920, DOI 10.1038/NMETH815
Cox G, 2004, MICROSC RES TECHNIQ, V63, P18, DOI 10.1002/jemt.10423
Dodt HU, 2007, NAT METHODS, V4, P331, DOI 10.1038/NMETH1036
Dunsby C, 2008, OPT EXPRESS, V16, P20306, DOI 10.1364/OE.16.020306
Erturk A, 2012, NAT MED, V18, P166, DOI 10.1038/nm.2600
Fahrbach FO, 2012, NAT COMMUN, V3, DOI 10.1038/ncomms1646
Feng GP, 2000, NEURON, V28, P41, DOI 10.1016/S0896-6273(00)00084-2
Fuchs E, 2002, OPT EXPRESS, V10, P145, DOI 10.1364/OE.10.000145
Hama H, 2011, NAT NEUROSCI, V14, P1481, DOI 10.1038/nn.2928
Helmstaedter M, 2008, CURR OPIN NEUROBIOL, V18, P633, DOI 10.1016/j.conb.2009.03.005
Holekamp TF, 2008, NEURON, V57, P661, DOI 10.1016/j.neuron.2008.01.011
Huisken J, 2004, SCIENCE, V305, P1007, DOI 10.1126/science.1100035
Huisken J, 2009, DEVELOPMENT, V136, P1963, DOI 10.1242/dev.022426
Huisken J, 2007, OPT LETT, V32, P2608, DOI 10.1364/OL.32.002608
Jährling Nina, 2010, Front Syst Neurosci, V4, P1, DOI 10.3389/neuro.06.001.2010
Jankowski J, 2009, CEREBELLUM, V8, P277, DOI 10.1007/s12311-009-0093-9
Jeong WK, 2010, IEEE T VIS COMPUT GR, V16, P1386, DOI 10.1109/TVCG.2010.168
Kalchmair S, 2010, OPT LETT, V35, P79, DOI 10.1364/OL.35.000079
Keller PJ, 2012, CURR OPIN NEUROBIOL, V22, P138, DOI 10.1016/j.conb.2011.08.003
Keller PJ, 2006, CURR OPIN CELL BIOL, V18, P117, DOI 10.1016/j.ceb.2005.12.012
Keller PJ, 2008, SCIENCE, V322, P1065, DOI 10.1126/science.1162493
Keller PJ, 2010, NAT METHODS, V7, P637, DOI [10.1038/nmeth.1476, 10.1038/NMETH.1476]
Kemper TL, 1998, J NEUROPATH EXP NEUR, V57, P645, DOI 10.1097/00005072-199807000-00001
Krzic U, 2012, NAT METHODS, V9, P730, DOI [10.1038/nmeth.2064, 10.1038/NMETH.2064]
Li AA, 2010, SCIENCE, V330, P1404, DOI 10.1126/science.1191776
Lichtman JW, 2008, NAT REV NEUROSCI, V9, P417, DOI 10.1038/nrn2391
Mayerich D, 2008, J MICROSC-OXFORD, V231, P134, DOI 10.1111/j.1365-2818.2008.02024.x
Mertz J, 2011, NAT METHODS, V8, P811, DOI [10.1038/nmeth.1709, 10.1038/NMETH.1707]
Mertz J, 2010, J BIOMED OPT, V15, DOI 10.1117/1.3324890
Mori S, 2009, CURR OPIN NEUROL, V22, P362, DOI 10.1097/WCO.0b013e32832d954b
Planchon TA, 2011, NAT METHODS, V8, P417, DOI [10.1038/nmeth.1586, 10.1038/NMETH.1586]
RITVO ER, 1986, AM J PSYCHIAT, V143, P862
Siedentopf H., 1903, ANN PHYS, V10, P1
Sotelo C, 2003, NAT REV NEUROSCI, V4, P71, DOI 10.1038/nrn1010
Spalteholz W, 1914, DURCHSICHTIGMACHEN M
Sporns O, 2005, PLOS COMPUT BIOL, V1, P245, DOI 10.1371/journal.pcbi.0010042
Tokunaga M, 2008, NAT METHODS, V5, P159, DOI [10.1038/nmeth1171, 10.1038/NMETH.1171]
Tomer R, 2012, NAT METHODS, V9, P755, DOI [10.1038/nmeth.2062, 10.1038/NMETH.2062]
Tomomura M, 2001, EUR J NEUROSCI, V14, P57, DOI 10.1046/j.0953-816x.2001.01624.x
Verveer PJ, 2007, NAT METHODS, V4, P311, DOI 10.1038/NMETH1017
VOIE AH, 1993, J MICROSC-OXFORD, V170, P229
WILSON T, 1987, OPT LETT, V12, P227, DOI 10.1364/OL.12.000227
Zipfel Warren R., 2003, Nature Biotechnology, V21, P1369, DOI 10.1038/nbt899
NR 53
TC 56
Z9 56
PU OPTICAL SOC AMER
PI WASHINGTON
PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA
SN 1094-4087
J9 OPT EXPRESS
JI Opt. Express
PD AUG 27
PY 2012
VL 20
IS 18
BP 20582
EP 20598
DI 10.1364/OE.20.020582
PG 17
WC Optics
SC Optics
GA 000UN
UT WOS:000308414800094
PM 23037106
ER
PT J
AU Redies, C
Hertel, N
Hubner, CA
AF Redies, Christoph
Hertel, Nicole
Huebner, Christian A.
TI Cadherins and neuropsychiatric disorders
SO BRAIN RESEARCH
LA English
DT Review
DE Brain development; Neural circuit; Synaptic function; Cadherin; Catenin;
Wnts; GSK3; Lithium; Disc1; Genetic Linkage; Genome-wide association
study; Autism; Schizophrenia; Bipolar disorder; Epilepsy; Cognitive
impairment; Addiction; Alcoholism
ID GENOME-WIDE ASSOCIATION; CENTRAL-NERVOUS-SYSTEM; DEFICIT HYPERACTIVITY
DISORDER; ALPHA-N-CATENIN; PROTOCADHERIN 19 MUTATIONS; BIPOLAR DISORDER;
DE-NOVO; SCHIZOAFFECTIVE DISORDER; MENTAL-RETARDATION; ALCOHOL
DEPENDENCE
AB Cadherins mediate cell cell adhesion but are also involved in intracellular signaling pathways associated with neuropsychiatric disease. Most of the similar to 100 cadherins that are expressed in the brain exhibit characteristic spatiotemporal expression profiles. Cadherins have been shown to regulate neural tube regionalization, neuronal migration, gray matter differentiation, neural circuit formation, spine morphology, synapse formation and synaptic remodeling. The dysfunction of the cadherin-based adhesive system may alter functional connectivity and coherent information processing in the human brain in neuropsychiatric disease. Several neuropsychiatric disorders, such as epilepsy/mental retardation, autism, bipolar disease and schizophrenia, have been associated with cadherins, mostly by genome-wide association studies. For example, CDH15 and PCDH19 are associated with cognitive impairment; CDH5, CDH8, CDH9, CDH10, CDH13, CDH15, PCDH10, PCDH19 and PCDHb4 with autism; CDH7, CDH12, CDH18, PCDH12 and FAT with bipolar disease and schizophrenia; and CDH11, CDH12 and CDH13 with methamphetamine and alcohol dependency. To date, disease-causing mutations are established for PCDH19 in patients with epilepsy, cognitive impairment and/or autistic features. In conclusion, genes encoding members of the cadherin superfamily are of special interest in the pathogenesis of neuropsychiatric disease because cadherins play a pivotal role in the development of the neural circuitry as well as in mature synaptic function. (C) 2012 Elsevier B.V. All rights reserved.
C1 [Redies, Christoph; Hertel, Nicole] Univ Jena, Inst Anat 1, Sch Med, Jena Univ Hosp, D-07740 Jena, Germany.
[Huebner, Christian A.] Univ Jena, Inst Human Genet, Sch Med, Jena Univ Hosp, D-07740 Jena, Germany.
RP Redies, C (reprint author), Univ Jena, Inst Anat 1, Sch Med, Jena Univ Hosp, Teichgraben 7, D-07740 Jena, Germany.
EM redies@mti.uni-jena.de; nicole.hertel@mti.uni-jena.de;
christian.huebner@mti.uni-jena.de
CR Abe K, 2004, NAT NEUROSCI, V7, P357, DOI 10.1038/nn1212
Abou Jamra R, 2008, MOL PSYCHIATR, V13, P277, DOI 10.1038/sj.mp.4002111
Arias-Vasquez A, 2011, GENES BRAIN BEHAV, V10, P844, DOI 10.1111/j.1601-183X.2011.00724.x
Arikkath J, 2008, TRENDS NEUROSCI, V31, P487, DOI 10.1016/j.tins.2008.07.001
BEESLEY PW, 1995, J NEUROCHEM, V64, P2288
Berx G., 2009, COLD SPRING HARB P A, V1a
Bhalla K, 2008, AM J HUM GENET, V83, P703, DOI 10.1016/j.ajhg.2008.10.020
Bishop KM, 2000, SCIENCE, V288, P344, DOI 10.1126/science.288.5464.344
Blair IP, 2006, MOL PSYCHIATR, V11, P372, DOI 10.1038/sj.mp.4001784
Bozdagi O, 2010, J NEUROSCI, V30, P9984, DOI 10.1523/JNEUROSCI.1223-10.2010
Brigidi GS, 2011, CURR OPIN NEUROBIOL, V21, P208, DOI 10.1016/j.conb.2010.12.004
Camacho A, 2012, EPILEPSY BEHAV, V24, P134, DOI 10.1016/j.yebeh.2012.02.023
Chu TT, 2010, J HUM GENET, V55, P285, DOI 10.1038/jhg.2010.24
Crow TJ, 2002, BRIT J PSYCHIAT, V181, P295, DOI 10.1192/bjp.181.4.295
Crow TJ, 2008, SCHIZOPHR RES, V102, P31, DOI 10.1016/j.schres.2008.03.010
Dean B, 2007, AUST NZ J PSYCHIAT, V41, P308, DOI 10.1080/00048670701213245
DeLisi LE, 2002, AM J PSYCHIAT, V159, P803, DOI 10.1176/appi.ajp.159.5.803
Depienne C, 2009, PLOS GENET, V5, DOI 10.1371/journal.pgen.1000381
Depienne C, 2012, HUM MUTAT, V33, P627, DOI 10.1002/humu.22029
Dibbens LM, 2011, NEUROLOGY, V76, P1514, DOI 10.1212/WNL.0b013e318217e7b6
Dibbens LM, 2008, NAT GENET, V40, P776, DOI 10.1038/ng.149
Edenberg HJ, 2010, ALCOHOL CLIN EXP RES, V34, P840, DOI 10.1111/j.1530-0277.2010.01156.x
El-Amraoui A, 2010, CSH PERSPECT BIOL, V2, DOI 10.1101/cshperspect.a003095
Fatemi SH, 2005, MOL PSYCHIATR, V10, P251, DOI 10.1038/sj.mp.4001613
Franco SJ, 2011, NEURON, V69, P482, DOI 10.1016/j.neuron.2011.01.003
Franke B, 2009, HUM GENET, V126, P13, DOI 10.1007/s00439-009-0663-4
GANZLER SII, 1995, J NEUROSCI, V15, P4157
Giouzeli M, 2004, AM J MED GENET B, V129B, P1, DOI 10.1002/ajmg.b.30036
Gould TD, 2007, NEUROPSYCHOPHARMACOL, V32, P2173, DOI 10.1038/sj.npp.1301338
Gregrio SP, 2009, PSYCHIAT RES, V165, P1, DOI 10.1016/j.psychres.2007.08.011
Gross J, 2003, FORTSCHR NEUROL PSYC, V71, P84, DOI 10.1055/s-2003-37212
Halbleib JM, 2006, GENE DEV, V20, P3199, DOI 10.1101/gad.1486806
Hattori T, 2010, MOL PSYCHIATR, V15, P798, DOI 10.1038/mp.2010.60
Henderson RH, 2010, MOL VIS, V16, P46
Hertel N, 2008, J COMP NEUROL, V508, P511, DOI [10.1002/cne.21696, 10.1002/ene.21696]
Hertel N, 2011, CEREB CORTEX, V21, P1105, DOI 10.1093/cercor/bhq183
Hertel N., 2012, J COMP NEUROL
Heuberger J, 2010, CSH PERSPECT BIOL, V2, DOI 10.1101/cshperspect.a002915
Heyers D, 2004, NEUROSCIENCE, V127, P901, DOI 10.1016/j.neuroscience.2004.05.023
Higurashi N, 2012, EPILEPSY RES, V99, P28, DOI 10.1016/j.eplepsyres.2011.10.014
Hirano S, 2012, PHYSIOL REV, V92, P597, DOI 10.1152/physrev.00014.2011
Hirano S, 2003, FRONT BIOSCI, V8, pD306, DOI 10.2741/972
Hirano S, 1999, J NEUROSCI, V19, P995
Hodgkinson CA, 2004, AM J HUM GENET, V75, P862, DOI 10.1086/425586
Hollnagel A, 2002, MOL CELL BIOL, V22, P4760, DOI 10.1128/MCB.22.13.4760-4770.2002
Homayouni R, 2001, BIOCHEM BIOPH RES CO, V289, P539, DOI 10.1006/bbrc.2001.5998
Hulpiau P, 2009, INT J BIOCHEM CELL B, V41, P349, DOI 10.1016/j.biocel.2008.09.027
Hulpiau P, 2011, MOL BIOL EVOL, V28, P647, DOI 10.1093/molbev/msq233
Hynes K, 2010, J MED GENET, V47, P211, DOI 10.1136/jmg.2009.068817
Inoue T, 2001, DEVELOPMENT, V128, P561
Inoue YU, 2008, MOL CELL NEUROSCI, V39, P95, DOI 10.1016/j.mcn.2008.05.020
Jamal SM, 2010, AM J MED GENET A, V152A, P2475, DOI 10.1002/ajmg.a.33611
Jee SH, 2010, AM J HUM GENET, V87, P545, DOI 10.1016/j.ajhg.2010.09.004
Johnson C, 2006, AM J MED GENET B, V141B, P844, DOI 10.1002/ajmg.b.30346
Jossin Y, 2011, NAT NEUROSCI, V14, P697, DOI 10.1038/nn.2816
Junghans D, 2008, EUR J NEUROSCI, V27, P559, DOI 10.1111/j.1460-9568.2008.06052.x
Katori S, 2009, J NEUROSCI, V29, P9137, DOI 10.1523/JNEUROSCI.5478-08.2009
Kim S.Y., 2011, NEUROSCIENCE, V170, P189
Klauck S.M., 2011, MOL BIOL NEUROPSYCHI, P81
Korematsu K, 1997, J COMP NEUROL, V387, P291
Krishna K, 2009, CEREB CORTEX, V19, P388
Krishna K.K., 2010, NEUROSCIENCE, V175, P37
Lasky-Su J, 2008, AM J MED GENET B, V147B, P1345, DOI 10.1002/ajmg.b.30867
Lesch KP, 2008, J NEURAL TRANSM, V115, P1573, DOI 10.1007/s00702-008-0119-3
Luo J, 2006, NEUROSCIENCE, V142, P1133, DOI 10.1016/j.neuroscience.2006.07.038
Luo JK, 2004, MOL CELL NEUROSCI, V25, P138, DOI 10.1016/j.mcn.2003.10.003
Lydall GJ, 2011, PSYCHIAT GENET, V21, P294, DOI 10.1097/YPG.0b013e32834915c2
Malinverno M, 2010, J NEUROSCI, V30, P16343, DOI 10.1523/JNEUROSCI.1984-10.2010
Mao YW, 2009, CELL, V136, P1017, DOI 10.1016/j.cell.2008.12.044
Marini C, 2010, NEUROLOGY, V75, P646, DOI 10.1212/WNL.0b013e3181ed9e67
Marmol F, 2008, PROG NEURO-PSYCHOPH, V32, P1761, DOI 10.1016/j.pnpbp.2008.08.012
Mash DC, 2007, PLOS ONE, V2, DOI 10.1371/journal.pone.0001187
MATSUNAGA M, 1988, NATURE, V334, P62, DOI 10.1038/334062a0
Mendez P, 2010, J CELL BIOL, V189, P589, DOI 10.1083/jcb.201003007
Mexal S, 2008, AM J MED GENET B, V147B, P759, DOI 10.1002/ajmg.b.30679
Millan JM, 2011, J OPHTHALMOL, DOI 10.1155/2011/417217
Miyake K, 2011, BMC NEUROSCI, V12, DOI 10.1186/1471-2202-12-81
Morrow EM, 2008, SCIENCE, V321, P218, DOI 10.1126/science.1157657
Muller U, 2008, CURR OPIN CELL BIOL, V20, P557, DOI 10.1016/j.ceb.2008.06.004
Neale BM, 2008, AM J MED GENET B, V147B, P1337, DOI 10.1002/ajmg.b.30866
Okuda T, 2007, P NATL ACAD SCI USA, V104, P13479, DOI 10.1073/pnas.0702334104
O'Roak BJ, 2012, NATURE, V485, P246, DOI 10.1038/nature10989
Ostergaard E, 2010, J MED GENET, V47, P665, DOI 10.1136/jmg.2009.069120
Pagnamenta AT, 2011, J MED GENET, V48, P48, DOI 10.1136/jmg.2010.079426
Park C, 2002, NAT GENET, V31, P279, DOI 10.1038/ng908
Pedrosa E, 2008, SCHIZOPHR RES, V102, P210, DOI 10.1016/j.schres.2008.04.013
Pedrosa E, 2010, J NEUROGENET, V24, P182, DOI 10.3109/01677063.2010.495182
Price SR, 2002, CELL, V109, P205, DOI 10.1016/S0092-8674(02)00695-5
Puelles L., 2004, RAT NERVOUS SYSTEM, P3
Rattner A, 2001, NEURON, V32, P775, DOI 10.1016/S0896-6273(01)00531-1
Redies C, 2005, CELL MOL LIFE SCI, V62, P2840, DOI 10.1007/s00018-005-5320-z
Redies C, 2000, PROG NEUROBIOL, V61, P611, DOI 10.1016/S0301-0082(99)00070-2
Redies C, 2011, CEREBELLUM, V10, P393, DOI 10.1007/s12311-010-0207-4
REDIES C, 1993, GLIA, V8, P161, DOI 10.1002/glia.440080304
Redies C, 2001, BIOESSAYS, V23, P1100, DOI 10.1002/bies.10014
Redies C, 1996, DEV BIOL, V180, P413, DOI 10.1006/dbio.1996.0315
REDIES C, 1993, J COMP NEUROL, V333, P398, DOI 10.1002/cne.903330307
REDIES C, 1995, EXP CELL RES, V220, P243, DOI 10.1006/excr.1995.1313
Redies C, 2000, J COMP NEUROL, V421, P481, DOI 10.1002/(SICI)1096-9861(20000612)421:4<481::AID-CNE3>3.0.CO;2-H
Riehl R, 1996, NEURON, V17, P837, DOI 10.1016/S0896-6273(00)80216-0
Rubenstein JLR, 1999, CEREB CORTEX, V9, P524, DOI 10.1093/cercor/9.6.524
Rudd MF, 2006, GENOME RES, V16, P693, DOI 10.1101/gr.5120106
Saglietti L, 2007, NEURON, V54, P461, DOI 10.1016/j.neuron.2007.04.012
Sanders SJ, 2011, NEURON, V70, P863, DOI 10.1016/j.neuron.2011.05.002
Schroeder DI, 2011, GENOME RES, V21, P1583, DOI 10.1101/gr.119131.110
Schwab SG, 1997, MOL PSYCHIATR, V2, P156, DOI 10.1038/sj.mp.4000263
Singh S.M., 2009, SCHIZOPHR RES, V116, P293
Sklar P, 2008, MOL PSYCHIATR, V13, P558, DOI 10.1038/sj.mp.4002151
Sokolov BP, 2003, J NEUROSCI RES, V72, P756, DOI 10.1002/jnr.10631
Soronen P, 2010, MOL PSYCHIATR, V15, P4, DOI 10.1038/mp.2009.86
Specchio N, 2011, EPILEPSIA, V52, P1251, DOI 10.1111/j.1528-1167.2011.03063.x
Specchio N, 2011, EPILEPSIA, V52, pE172, DOI 10.1111/j.1528-1167.2011.03193.x
Speevak MD, 2011, AM J MED GENET B, V156B, P484, DOI 10.1002/ajmg.b.31186
SPERRY RW, 1963, P NATL ACAD SCI USA, V50, P703, DOI 10.1073/pnas.50.4.703
Suzuki SC, 2007, J NEUROSCI, V27, P3466, DOI 10.1523/JNEUROSCI.0243-07.2007
Takeichi M, 2007, NAT REV NEUROSCI, V8, P11, DOI 10.1038/nrn2043
Taniguchi H, 2006, DEVELOPMENT, V133, P1923, DOI 10.1242/dev.02354
Terracciano A, 2010, BIOL PSYCHIAT, V68, P811, DOI 10.1016/j.biopsych.2010.06.030
Terracciano A, 2010, MOL PSYCHIATR, V15, P647, DOI 10.1038/mp.2008.113
Thalmeier A, 2008, INT J NEUROPSYCHOPH, V11, P217, DOI 10.1017/S1461145707007894
Tissir F, 2005, NAT NEUROSCI, V8, P451, DOI 10.1038/nn1428
Togashi H, 2002, NEURON, V35, P77, DOI 10.1016/S0896-6273(02)00748-1
Treubert-Zimmermann U, 2002, J NEUROSCI, V22, P7617
Treutlein J, 2009, ARCH GEN PSYCHIAT, V66, P773, DOI 10.1001/archgenpsychiatry.2009.83
Uemura M, 2007, NAT NEUROSCI, V10, P1151, DOI 10.1038/nn1960
Uhl GR, 2008, ANN NY ACAD SCI, V1141, P318, DOI 10.1196/annals.1441.018
Uhl GR, 2008, ARCH GEN PSYCHIAT, V65, P345, DOI 10.1001/archpsyc.65.3.345
Van Broeckhoven C, 1999, AM J MED GENET, V88, P263, DOI 10.1002/(SICI)1096-8628(19990618)88:3<263::AID-AJMG10>3.0.CO;2-5
Vincent A.K., CLIN GENET IN PRESS
Wang K, 2009, NATURE, V459, P528, DOI 10.1038/nature07999
Wang XZ, 2002, NEURON, V36, P843, DOI 10.1016/S0896-6273(02)01090-5
Webb S., 2010, HUM GENET, V129, P59
Weiner JA, 2005, P NATL ACAD SCI USA, V102, P8, DOI 10.1073/pnas.0407931101
Weiss LA, 2009, NATURE, V461, P802, DOI 10.1038/nature08490
Wildenauer D.B., 2009, NUCL ACIDS MOL BIOL
Willemsen MH, 2010, EUR J HUM GENET, V18, P429, DOI 10.1038/ejhg.2009.192
Wohrn J.C., 1999, NEUROSCIENCE, V90, P985
Wohrn J.-C.P., 1998, J COMP NEUROL, V396, P20
Yagi T, 2000, GENE DEV, V14, P1169
YAMAGATA M, 1995, DEVELOPMENT, V121, P189
Yasuda S, 2007, NEURON, V56, P456, DOI 10.1016/j.neuron.2007.08.020
Ying J, 2006, ONCOGENE, V25, P1070, DOI 10.1038/sj.onc.1209154
Yoon MS, 2000, J COMP NEUROL, V421, P461, DOI 10.1002/(SICI)1096-9861(20000612)421:4<461::AID-CNE2>3.0.CO;2-M
Zhou KX, 2008, AM J MED GENET B, V147B, P1392, DOI 10.1002/ajmg.b.30878
NR 144
TC 46
Z9 46
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0006-8993
J9 BRAIN RES
JI Brain Res.
PD AUG 27
PY 2012
VL 1470
BP 130
EP 144
DI 10.1016/j.brainres.2012.06.020
PG 15
WC Neurosciences
SC Neurosciences & Neurology
GA 004KB
UT WOS:000308679500015
PM 22765916
ER
PT J
AU Wall, DP
Dally, R
Luyster, R
Jung, JY
DeLuca, TF
AF Wall, Dennis P.
Dally, Rebecca
Luyster, Rhiannon
Jung, Jae-Yoon
DeLuca, Todd F.
TI Use of Artificial Intelligence to Shorten the Behavioral Diagnosis of
Autism
SO PLOS ONE
LA English
DT Article
ID PERVASIVE DEVELOPMENTAL DISORDERS; SPECTRUM DISORDERS; PRIMARY-CARE;
INTERVIEW; BIOINFORMATICS; QUESTIONNAIRE; RELIABILITY; RESOURCE
AB The Autism Diagnostic Interview-Revised (ADI-R) is one of the most commonly used instruments for assisting in the behavioral diagnosis of autism. The exam consists of 93 questions that must be answered by a care provider within a focused session that often spans 2.5 hours. We used machine learning techniques to study the complete sets of answers to the ADI-R available at the Autism Genetic Research Exchange (AGRE) for 891 individuals diagnosed with autism and 75 individuals who did not meet the criteria for an autism diagnosis. Our analysis showed that 7 of the 93 items contained in the ADI-R were sufficient to classify autism with 99.9% statistical accuracy. We further tested the accuracy of this 7-question classifier against complete sets of answers from two independent sources, a collection of 1654 individuals with autism from the Simons Foundation and a collection of 322 individuals with autism from the Boston Autism Consortium. In both cases, our classifier performed with nearly 100% statistical accuracy, properly categorizing all but one of the individuals from these two resources who previously had been diagnosed with autism through the standard ADI-R. Our ability to measure specificity was limited by the small numbers of non-spectrum cases in the research data used, however, both real and simulated data demonstrated a range in specificity from 99% to 93.8%. With incidence rates rising, the capacity to diagnose autism quickly and effectively requires careful design of behavioral assessment methods. Ours is an initial attempt to retrospectively analyze large data repositories to derive an accurate, but significantly abbreviated approach that may be used for rapid detection and clinical prioritization of individuals likely to have an autism spectrum disorder. Such a tool could assist in streamlining the clinical diagnostic process overall, leading to faster screening and earlier treatment of individuals with autism.
C1 [Wall, Dennis P.; Dally, Rebecca; Jung, Jae-Yoon; DeLuca, Todd F.] Harvard Univ, Sch Med, Ctr Biomed Informat, Boston, MA 02115 USA.
[Wall, Dennis P.] Beth Israel Deaconess Med Ctr, Dept Pathol, Boston, MA 02215 USA.
[Luyster, Rhiannon] Boston Childrens Hosp, Labs Cognit Neurosci, Boston, MA USA.
RP Wall, DP (reprint author), Harvard Univ, Sch Med, Ctr Biomed Informat, Boston, MA 02115 USA.
EM dpwall@hms.harvard.edu
FU National Institutes of Health [1R01MH090611-01A1]
FX The work was supported by the National Institutes of Health under Grant
No. 1R01MH090611-01A1 awarded to DPW. The funders had no role in study
design, data collection and analysis, decision to publish, or
preparation of the manuscript.
CR Aldridge FJ, 2012, J AUTISM DEV DISORD, V42, P294, DOI 10.1007/s10803-011-1242-9
BAILEY A, 1995, PSYCHOL MED, V25, P63
Bernier R, 2010, CHILD ADOL PSYCH CL, V19, P855, DOI 10.1016/j.chc.2010.07.005
Berument SK, 1999, BRIT J PSYCHIAT, V175, P444, DOI 10.1192/bjp.175.5.444
Cicchetti DV, 2008, J AUTISM DEV DISORD, V38, P764, DOI 10.1007/s10803-007-0448-3
Cohen W., 1995, 12 INT C MACH LEARN, P115
Eaves LC, 2006, J DEV BEHAV PEDIATR, V27, pS95, DOI 10.1097/00004703-200604002-00007
Fischbach GD, 2010, NEURON, V68, P192, DOI 10.1016/j.neuron.2010.10.006
Frank E, 2004, BIOINFORMATICS, V20, P2479, DOI 10.1093/bioinformatics/bth261
Frank E., 1998, GENERATING ACCURATE
Frank Eibe, 2001, ECML, P145
Freund Y, 1999, ALTERNATING DECISION, P124
Freund Y, 1996, EXPT NEW BOOSTING AL, P148
Gaines B. R., 1995, Journal of Intelligent Information Systems: Integrating Artificial Intelligence and Database Technologies, V5, DOI 10.1007/BF00962234
Geschwind DH, 2001, AM J HUM GENET, V69, P463, DOI 10.1086/321292
Gura GF, 2011, J DEV BEHAV PEDIATR, V32, P48, DOI 10.1097/DBP.0b013e3182040aea
Hall M., 2009, SIGKDD EXPLORATIONS, V11, P1, DOI DOI 10.1145/1656274.1656278
Hill A, 2001, PSYCHOPATHOLOGY, V34, P187, DOI 10.1159/000049305
Holmes G, 2001, MULTICLASS ALTERNATI, P161
HOLTE RC, 1993, MACH LEARN, V11, P63, DOI 10.1023/A:1022631118932
Howlin P, 1998, CHILDREN AUTISM ASPE
Kohavi R., 1995, STUDY CROSS VALIDATI, P1137
LORD C, 1989, J AUTISM DEV DISORD, V19, P185, DOI 10.1007/BF02211841
LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
Lord C, 2012, ARCH GEN PSYCHIAT, V69, P306, DOI 10.1001/archgenpsychiatry.2011.148
Martin B., 1995, INSTANCE BASED LEARN
Olshen R., 1984, CLASSIFICATION REGRE, V1st
Pinto-Martin JA, 2008, J DEV BEHAV PEDIATR, V29, P345, DOI 10.1097/DBP.0b013e31818914cf
Pisula E., 2003, ARCH PSYCHIAT PSYCHO, V5, P51
Poustka F, 1996, PSYCHOPATHOLOGY, V29, P145
Quinlan J R., 1993, C4 5
Risi S, 2006, J AM ACAD CHILD PSY, V45, P1094, DOI 10.1097/01.chi.0000227880.42780.0e
Robins DL, 2001, J AUTISM DEV DISORD, V31, P131, DOI 10.1023/A:1010738829569
Schanding Jr. GT, 2011, J AUTISM DEV DISORD
Shi H., 2007, THESIS U WAIKATO
Wall DP, 2012, TRANSLATIONAL PSYCHI, P2
Warren Z, 2012, AUTISM RES, V5, P31, DOI 10.1002/aur.230
Wiggins LD, 2006, J DEV BEHAV PEDIATR, V27, pS79, DOI 10.1097/00004703-200604002-00005
Wilkinson DJ, 2007, BRIEF BIOINFORM, V8, P109, DOI 10.1093/bib/bbm007
NR 39
TC 2
Z9 2
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD AUG 27
PY 2012
VL 7
IS 8
AR e43855
DI 10.1371/journal.pone.0043855
PG 8
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 995WH
UT WOS:000308044800067
PM 22952789
ER
PT J
AU Gandal, MJ
Nesbitt, AM
McCurdy, RM
Alter, MD
AF Gandal, Michael J.
Nesbitt, Addie May
McCurdy, Richard M.
Alter, Mark D.
TI Measuring the Maturity of the Fast-Spiking Interneuron Transcriptional
Program in Autism, Schizophrenia, and Bipolar Disorder
SO PLOS ONE
LA English
DT Article
ID MITOCHONDRIAL DYSFUNCTION; PSYCHIATRIC-DISORDERS; GENE-EXPRESSION;
PATERNAL AGE; SPECTRUM DISORDERS; PREFRONTAL CORTEX; NEURONS;
PARVALBUMIN; DISEASE
AB Background: Emerging evidence suggests that fast-spiking (FS) interneurons are disrupted in multiple neuropsychiatric disorders including autism, schizophrenia, and bipolar disorder. FS cells, which are the primary source of synaptic inhibition, are critical for temporally organizing brain activity, regulating brain maturation, and modulating critical developmental periods in multiple cortical systems. Reduced expression of parvalbumin, a marker of mature FS cells, has been reported in individuals with schizophrenia and bipolar disorder and in mouse models of schizophrenia and autism. Although these results suggest that FS cells may be immature in neuropsychiatric disease, this possibility had not previously been formally assessed.
Methods: This study used time-course global expression data from developing FS cells to create a maturation index that tracked with the developmental age of purified cortical FS cells. The FS cell maturation index was then applied to global gene expression data from human cortex to estimate the maturity of the FS cell developmental program in the context of various disease states. Specificity of the index for FS cells was supported by a highly significant correlation of maturation index measurements with parvalbumin expression levels that withstood correction for multiple covariates.
Conclusions: Results suggest the FS cell developmental gene expression program is immature in autism, schizophrenia, and bipolar disorder. More broadly, the current study indicates that cell-type specific maturation indices can be used to measure the maturity of developmental programs even in data from mixed cell types such as those found in brain homogenates.
C1 [Gandal, Michael J.; Nesbitt, Addie May; McCurdy, Richard M.; Alter, Mark D.] Univ Penn, Dept Psychiat, Ctr Neurobiol & Behav, Philadelphia, PA 19104 USA.
RP Gandal, MJ (reprint author), Univ Penn, Dept Psychiat, Ctr Neurobiol & Behav, Philadelphia, PA 19104 USA.
EM markalter1968@gmail.com
FU Simon's Foundation SFARI Explorer's Award [1K08MH08228-01A2]
FX Funding provided by Simon's Foundation SFARI Explorer's Award
1K08MH08228-01A2. The funders had no role in study design, data
collection and analysis, decision to publish, or preparation of the
manuscript.
CR Arlotta P, 2005, NEURON, V45, P207, DOI 10.1016/j.neuron.2004.12.036
Berghuis P, 2004, INT J DEV NEUROSCI, V22, P533, DOI 10.1016/j.ijdevneu.2004.07.012
Buchstaller J, 2004, J NEUROSCI, V24, P2357, DOI 10.1523/JNEUROSCI.4083-03.2004
Buizer-Voskamp JE, 2011, SCHIZOPHR RES, V129, P128, DOI 10.1016/j.schres.2011.03.021
Cahoy JD, 2008, J NEUROSCI, V28, P264, DOI 10.1523/JNEUROSCI.4178-07.2008
Carlson GC, 2011, P NATL ACAD SCI USA, V108, pE962, DOI 10.1073/pnas.1109625108
Clay HB, 2011, INT J DEV NEUROSCI, V29, P311, DOI 10.1016/j.ijdevneu.2010.08.007
Meyer U, 2011, PEDIATR RES, V69, p26R, DOI 10.1203/PDR.0b013e318212c196
DAWSON G, 1988, J AUTISM DEV DISORD, V18, P493, DOI 10.1007/BF02211869
de Geus EJC, 2010, GENOME MED, V2, DOI 10.1186/gm184
Dennis Glynn Jr, 2003, Genome Biol, V4, pP3, DOI 10.1186/gb-2003-4-5-p3
Frans EM, 2008, ARCH GEN PSYCHIAT, V65, P1034, DOI 10.1001/archpsyc.65.9.1034
Frye RE, 2011, PEDIATR RES, V69, p41R, DOI 10.1203/PDR.0b013e318212f16b
Giulivi C, 2010, JAMA-J AM MED ASSOC, V304, P2389, DOI 10.1001/jama.2010.1706
Gogolla N, 2009, J NEURODEV DISORD, V1, P172, DOI 10.1007/s11689-009-9023-x
Harris LW, 2009, BMC MED GENOMICS, V2, DOI 10.1186/1755-8794-2-28
Hashimoto T, 2003, J NEUROSCI, V23, P6315
Hensch TK, 2005, NAT REV NEUROSCI, V6, P877, DOI 10.1038/nrn1787
Huang DW, 2009, NAT PROTOC, V4, P44, DOI 10.1038/nprot.2008.211
Lewis DA, 2005, NAT REV NEUROSCI, V6, P312, DOI 10.1038/nrn1648
Lopez-Castroman J, 2010, SCHIZOPHR RES, V116, P184, DOI 10.1016/j.schres.2009.11.006
Marin O, 2012, NAT REV NEUROSCI, V13, P107, DOI 10.1038/nrn3155
McAlonan GM, 2010, NEUROSIGNALS, V18, P129, DOI 10.1159/000321080
Meyer U, 2007, NEUROSCIENTIST, V13, P241, DOI 10.1177/1073858406296401
Okaty BW, 2009, J NEUROSCI, V29, P7040, DOI 10.1523/JNEUROSCI.0105-09.2009
Oliveira G, 2005, DEV MED CHILD NEUROL, V47, P185, DOI 10.1017/S0012162205000332
Palmieri L, 2010, BBA-BIOENERGETICS, V1797, P1130, DOI 10.1016/j.bbabio.2010.04.018
Poling JS, 2006, J CHILD NEUROL, V21, P170, DOI 10.2310/7010.2006.00032
Rich BA, 2007, AM J PSYCHIAT, V164, P309, DOI 10.1176/appi.ajp.164.2.309
Rossignol DA, 2012, MOL PSYCHIATR, V17, P290, DOI 10.1038/mp.2010.136
Saha S, 2009, SCHIZOPHR RES, V115, P130, DOI 10.1016/j.schres.2009.09.012
Scaglia F, 2010, DEV DISABIL RES REV, V16, P136, DOI 10.1002/ddrr.115
Sohal VS, 2009, NATURE, V459, P698, DOI 10.1038/nature07991
Tabares-Seisdedos R, 2009, MOL PSYCHIATR, V14, P563, DOI 10.1038/mp.2009.2
Wang AY, 2011, ACTA NEUROPATHOL, V122, P615, DOI 10.1007/s00401-011-0881-4
NR 35
TC 10
Z9 10
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD AUG 24
PY 2012
VL 7
IS 8
AR e41215
DI 10.1371/journal.pone.0041215
PG 8
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 998GM
UT WOS:000308225500005
PM 22936973
ER
PT J
AU Hu, ZT
Hom, S
Kudze, T
Tong, XJ
Choi, S
Aramuni, G
Zhang, WQ
Kaplan, JM
AF Hu, Zhitao
Hom, Sabrina
Kudze, Tambudzai
Tong, Xia-Jing
Choi, Seungwon
Aramuni, Gayane
Zhang, Weiqi
Kaplan, Joshua M.
TI Neurexin and Neuroligin Mediate Retrograde Synaptic Inhibition in C.
elegans
SO SCIENCE
LA English
DT Article
ID SPECTRUM DISORDERS; AUTISM; MATURATION; MUTATIONS; CELL
AB The synaptic adhesion molecules neurexin and neuroligin alter the development and function of synapses and are linked to autism in humans. Here, we found that Caenorhabditis elegans neurexin (NRX-1) and neuroligin (NLG-1) mediated a retrograde synaptic signal that inhibited neurotransmitter release at neuromuscular junctions. Retrograde signaling was induced in mutants lacking a muscle microRNA (miR-1) and was blocked in mutants lacking NLG-1 or NRX-1. Release was rapid and abbreviated when the retrograde signal was on, whereas release was slow and prolonged when retrograde signaling was blocked. The retrograde signal adjusted release kinetics by inhibiting exocytosis of synaptic vesicles (SVs) that are distal to the site of calcium entry. Inhibition of release was mediated by increased presynaptic levels of tomosyn, an inhibitor of SV fusion.
C1 [Hu, Zhitao; Hom, Sabrina; Kudze, Tambudzai; Tong, Xia-Jing; Choi, Seungwon; Kaplan, Joshua M.] Massachusetts Gen Hosp, Dept Mol Biol, Boston, MA 02114 USA.
[Hu, Zhitao; Hom, Sabrina; Tong, Xia-Jing; Choi, Seungwon; Kaplan, Joshua M.] Harvard Univ, Sch Med, Dept Neurobiol, Boston, MA 02115 USA.
[Hom, Sabrina; Choi, Seungwon; Kaplan, Joshua M.] Harvard Univ, Sch Med, Program Neurosci, Boston, MA 02115 USA.
[Aramuni, Gayane] Max Planck Inst Neurobiol, D-82152 Martinsried, Germany.
[Zhang, Weiqi] Univ Munster, Dept Psychiat, D-48149 Munster, Germany.
RP Kaplan, JM (reprint author), Massachusetts Gen Hosp, Dept Mol Biol, Boston, MA 02114 USA.
EM kaplan@molbio.mgh.harvard.edu
FU NSF; NIH [NS32196]; Simons Foundation for Autism Research [SF177948]
FX We thank the following for strains, advice, reagents, and comments on
the manuscript: C. elegans stock center, S. Mitani, S. Sassi, B. Seed,
and members of the Kaplan and Ruvkun labs. This work was supported by an
NSF predoctoral fellowship (S. H.) and by research grants to J.M.K. from
the NIH (NS32196) and from the Simons Foundation for Autism Research
(SF177948). Additional data described in the manuscript are presented in
the supplementary materials.
CR Arnold PD, 2006, ARCH GEN PSYCHIAT, V63, P769, DOI 10.1001/archpsyc.63.7.769
Atluri PP, 1996, J NEUROSCI, V16, P5661
Bai JH, 2010, CELL, V143, P430, DOI 10.1016/j.cell.2010.09.024
Chen KY, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0011115
Etherton M, 2011, P NATL ACAD SCI USA, V108, P13764, DOI 10.1073/pnas.1111093108
Feinberg EH, 2008, NEURON, V57, P353, DOI 10.1016/j.neuron.2007.11.030
Foss-Feig JH, 2010, EXP BRAIN RES, V203, P381, DOI 10.1007/s00221-010-2240-4
Futai K, 2007, NAT NEUROSCI, V10, P186, DOI 10.1038/nn1837
Gracheva EO, 2006, PLOS BIOL, V4, P1426, DOI 10.1371/journal.pbio.0040261
Hoon M, 2011, P NATL ACAD SCI USA, V108, P3053, DOI 10.1073/pnas.1006946108
Hunter JW, 2010, DIS MODEL MECH, V3, P366, DOI 10.1242/dmm.003442
Jamain S, 2003, NAT GENET, V34, P27, DOI 10.1038/ng1136
Kattenstroth G, 2004, P NATL ACAD SCI USA, V101, P2607, DOI 10.1073/pnas.0308626100
Liu Q, 2005, J NEUROSCI, V25, P6745, DOI 10.1523/JNEUROSCI.1730-05.2005
McEwen JM, 2006, NEURON, V51, P303, DOI 10.1016/j.neuron.2006.06.025
Neale BM, 2012, NATURE, V485, P242, DOI 10.1038/nature11011
Novara F, 2010, CLIN GENET, V78, P471, DOI 10.1111/j.1399-0004.2010.01413.x
Roberts TPL, 2010, AUTISM RES, V3, P8, DOI 10.1002/aur.111
Simon DJ, 2008, CELL, V133, P903, DOI 10.1016/j.cell.2008.04.035
Sudhof TC, 2008, NATURE, V455, P903, DOI 10.1038/nature07456
Taniguchi H, 2007, J NEUROSCI, V27, P2815, DOI 10.1523/JNEUROSCI.0032-07.2007
Varoqueaux F, 2006, NEURON, V51, P741, DOI 10.1016/j.neuron.2006.09.003
Welch JM, 2007, NATURE, V448, P894, DOI 10.1038/nature06104
Wittenmayer N, 2009, P NATL ACAD SCI USA, V106, P13564, DOI 10.1073/pnas.0905819106
NR 24
TC 18
Z9 21
PU AMER ASSOC ADVANCEMENT SCIENCE
PI WASHINGTON
PA 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA
SN 0036-8075
J9 SCIENCE
JI Science
PD AUG 24
PY 2012
VL 337
IS 6097
BP 980
EP 984
DI 10.1126/science.1224896
PG 5
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 992VI
UT WOS:000307807600049
PM 22859820
ER
PT J
AU Callaway, E
AF Callaway, Ewen
TI GENETICS Fathers bequeath more mutations as they age
SO NATURE
LA English
DT News Item
ID DE-NOVO MUTATIONS; AUTISM
CR HALDANE JBS, 1947, ANN EUGENIC, V13, P262
Kong A, 2012, NATURE, V488, P471, DOI 10.1038/nature11396
Neale BM, 2012, NATURE, V485, P242, DOI 10.1038/nature11011
O'Roak BJ, 2012, NATURE, V485, P246, DOI 10.1038/nature10989
Sanders SJ, 2012, NATURE, V485, P237, DOI 10.1038/nature10945
NR 5
TC 3
Z9 3
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0028-0836
J9 NATURE
JI Nature
PD AUG 23
PY 2012
VL 488
IS 7412
BP 439
EP 439
PG 1
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 992FS
UT WOS:000307761600007
PM 22914142
ER
PT J
AU Kondrashov, A
AF Kondrashov, Alexey
TI GENETICS The rate of human mutation
SO NATURE
LA English
DT Editorial Material
ID CONSEQUENCES; SELECTION; FITNESS; AUTISM
C1 [Kondrashov, Alexey] Univ Michigan, Dept Ecol & Evolutionary Biol, Ann Arbor, MI 48109 USA.
[Kondrashov, Alexey] Univ Michigan, Inst Life Sci, Ann Arbor, MI 48109 USA.
RP Kondrashov, A (reprint author), Univ Michigan, Dept Ecol & Evolutionary Biol, Ann Arbor, MI 48109 USA.
EM kondrash@umich.edu
CR Crow JF, 1997, P NATL ACAD SCI USA, V94, P8380, DOI 10.1073/pnas.94.16.8380
Goriely A, 2012, AM J HUM GENET, V90, P175, DOI 10.1016/j.ajhg.2011.12.017
Keightley PD, 2012, GENETICS, V190, P295, DOI 10.1534/genetics.111.134668
Keyes KM, 2012, INT J EPIDEMIOL, V41, P495, DOI 10.1093/ije/dyr193
Kong A, 2012, NATURE, V488, P471, DOI 10.1038/nature11396
Saha S, 2009, PLOS MED, V6, DOI 10.1371/journal.pmed.1000040
Sanders SJ, 2012, NATURE, V485, P237, DOI 10.1038/nature10945
Shabalina SA, 1997, P NATL ACAD SCI USA, V94, P13034, DOI 10.1073/pnas.94.24.13034
Shabalina SA, 2001, TRENDS GENET, V17, P373, DOI 10.1016/S0168-9525(01)02344-7
SHIMMIN LC, 1993, NATURE, V362, P745, DOI 10.1038/362745a0
van Boxtel R, 2008, CARCINOGENESIS, V29, P1290, DOI 10.1093/carcin/bgn094
Wimmer K, 2008, HUM GENET, V124, P105, DOI 10.1007/s00439-008-0542-4
NR 12
TC 4
Z9 4
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0028-0836
J9 NATURE
JI Nature
PD AUG 23
PY 2012
VL 488
IS 7412
BP 467
EP 468
PG 2
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 992FS
UT WOS:000307761600026
PM 22914161
ER
PT J
AU Kong, A
Frigge, ML
Masson, G
Besenbacher, S
Sulem, P
Magnusson, G
Gudjonsson, SA
Sigurdsson, A
Jonasdottir, A
Jonasdottir, A
Wong, WSW
Sigurdsson, G
Walters, GB
Steinberg, S
Helgason, H
Thorleifsson, G
Gudbjartsson, DF
Helgason, A
Magnusson, OT
Thorsteinsdottir, U
Stefansson, K
AF Kong, Augustine
Frigge, Michael L.
Masson, Gisli
Besenbacher, Soren
Sulem, Patrick
Magnusson, Gisli
Gudjonsson, Sigurjon A.
Sigurdsson, Asgeir
Jonasdottir, Aslaug
Jonasdottir, Adalbjorg
Wong, Wendy S. W.
Sigurdsson, Gunnar
Walters, G. Bragi
Steinberg, Stacy
Helgason, Hannes
Thorleifsson, Gudmar
Gudbjartsson, Daniel F.
Helgason, Agnar
Magnusson, Olafur Th.
Thorsteinsdottir, Unnur
Stefansson, Kari
TI Rate of de novo mutations and the importance of father's age to disease
risk
SO NATURE
LA English
DT Article
ID AUTISM SPECTRUM DISORDERS; SCHIZOPHRENIA; HUMANS; CONSEQUENCES;
NUCLEOTIDE; PATTERNS; NRXN1
AB Mutations generate sequence diversity and provide a substrate for selection. The rate of de novo mutations is therefore of major importance to evolution. Here we conduct a study of genome-wide mutation rates by sequencing the entire genomes of 78 Icelandic parent-offspring trios at high coverage. We show that in our samples, with an average father's age of 29.7, the average de novo mutation rate is 1.20 x 10(-8) per nucleotide per generation. Most notably, the diversity in mutation rate of single nucleotide polymorphisms is dominated by the age of the father at conception of the child. The effect is an increase of about two mutations per year. An exponential model estimates paternal mutations doubling every 16.5 years. After accounting for random Poisson variation, father's age is estimated to explain nearly all of the remaining variation in the de novo mutation counts. These observations shed light on the importance of the father's age on the risk of diseases such as schizophrenia and autism.
C1 [Kong, Augustine; Frigge, Michael L.; Masson, Gisli; Besenbacher, Soren; Sulem, Patrick; Magnusson, Gisli; Gudjonsson, Sigurjon A.; Sigurdsson, Asgeir; Jonasdottir, Aslaug; Jonasdottir, Adalbjorg; Sigurdsson, Gunnar; Walters, G. Bragi; Steinberg, Stacy; Helgason, Hannes; Thorleifsson, Gudmar; Gudbjartsson, Daniel F.; Helgason, Agnar; Magnusson, Olafur Th.; Thorsteinsdottir, Unnur; Stefansson, Kari] deCODE Genet, IS-101 Reykjavik, Iceland.
[Besenbacher, Soren] Aarhus Univ, Bioinformat Res Ctr, DK-8000 Aarhus, Denmark.
[Wong, Wendy S. W.] Illumina Cambridge Ltd, Saffron Walden CB10 1XL, Essex, England.
[Thorsteinsdottir, Unnur; Stefansson, Kari] Univ Iceland, Fac Med, IS-101 Reykjavik, Iceland.
RP Kong, A (reprint author), deCODE Genet, Sturlugata 8, IS-101 Reykjavik, Iceland.
EM kong@decode.is; kari.stefansson@decode.is
FU National Institutes of Health [MH071425]; European Community
[HEALTH-F2-2009-223423, IAPP-MC-251592]; European Community IMI grant
EU-AIMS [115300]
FX This research was partly funded by The National Institutes of Health
grant MH071425 (K.S.); the European Community's Seventh Framework
Programme, PsychCNVs project, grant agreement HEALTH-F2-2009-223423, and
NextGene project, grant agreement IAPP-MC-251592; The European Community
IMI grant EU-AIMS, grant agreement 115300.
CR Boyden LM, 2012, NATURE, V482, P98, DOI 10.1038/nature10814
Conrad DF, 2011, NAT GENET, V43, P712, DOI 10.1038/ng.862
COULONDRE C, 1978, NATURE, V274, P775, DOI 10.1038/274775a0
Croen LA, 2007, ARCH PEDIAT ADOL MED, V161, P334, DOI 10.1001/archpedi.161.4.334
Crow JF, 2000, NAT REV GENET, V1, P40, DOI 10.1038/35049558
Duong L, 2012, AM J MED GENET B, V159B, P354, DOI 10.1002/ajmg.b.32036
Gauthier J, 2011, HUM GENET, V130, P563, DOI 10.1007/s00439-011-0975-z
Holm H, 2011, NAT GENET, V43, P316, DOI 10.1038/ng.781
Keightley PD, 2009, GENOME RES, V19, P1195, DOI 10.1101/gr.091231.109
Keightley PD, 2012, GENETICS, V190, P295, DOI 10.1534/genetics.111.134668
Kirov G, 2008, HUM MOL GENET, V17, P458, DOI 10.1093/hmg/ddm323
Kondrashov AS, 2003, HUM MUTAT, V21, P12, DOI 10.1002/humu.10147
Kong A, 2004, NAT GENET, V36, P1203, DOI 10.1038/ng1445
Levinson DF, 2011, AM J PSYCHIAT, V168, P302, DOI 10.1176/appi.ajp.2010.10060876
Li H, 2009, BIOINFORMATICS, V25, P1754, DOI 10.1093/bioinformatics/btp324
Lynch M, 2010, P NATL ACAD SCI USA, V107, P961, DOI 10.1073/pnas.0912629107
Malaspina D, 2001, SCHIZOPHRENIA BULL, V27, P379
McKenna A, 2010, GENOME RES, V20, P1297, DOI 10.1101/gr.107524.110
Nachman MW, 2000, GENETICS, V156, P297
Neale BM, 2012, NATURE, V485, P242, DOI 10.1038/nature11011
O'Roak BJ, 2012, NATURE, V485, P246, DOI 10.1038/nature10989
Rafnar T, 2011, NAT GENET, V43, P1104, DOI 10.1038/ng.955
Roach JC, 2010, SCIENCE, V328, P636, DOI 10.1126/science.1186802
Rujescu D, 2009, HUM MOL GENET, V18, P988, DOI 10.1093/hmg/ddn351
Sanders SJ, 2012, NATURE, V485, P237, DOI 10.1038/nature10945
Sulem P, 2011, NAT GENET, V43, P1127, DOI 10.1038/ng.972
Xue YL, 2009, CURR BIOL, V19, P1453, DOI 10.1016/j.cub.2009.07.032
NR 27
TC 355
Z9 365
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0028-0836
J9 NATURE
JI Nature
PD AUG 23
PY 2012
VL 488
IS 7412
BP 471
EP 475
DI 10.1038/nature11396
PG 5
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 992FS
UT WOS:000307761600028
PM 22914163
ER
PT J
AU Srivastava, DP
Jones, KA
Woolfrey, KM
Burgdorf, J
Russell, TA
Kalmbach, A
Lee, H
Yang, C
Bradberry, MM
Wokosin, D
Moskal, JR
Casanova, MF
Waters, J
Penzes, P
AF Srivastava, Deepak P.
Jones, Kelly A.
Woolfrey, Kevin M.
Burgdorf, Jeffrey
Russell, Theron A.
Kalmbach, Abigail
Lee, Hyerin
Yang, Connie
Bradberry, Mazdak M.
Wokosin, David
Moskal, Joseph R.
Casanova, Manuel F.
Waters, Jack
Penzes, Peter
TI Social, Communication, and Cortical Structural Impairments in
Epac2-Deficient Mice
SO JOURNAL OF NEUROSCIENCE
LA English
DT Article
ID ANTERIOR CINGULATE CORTEX; ULTRASONIC VOCALIZATIONS; MOUSE MODELS;
AUTISM; CAMP; DISORDER; MEMORY; RAP1; GENE; SCHIZOPHRENIA
AB Deficits in social and communication behaviors are common features of a number of neurodevelopmental disorders. However, the molecular and cellular substrates of these higher order brain functions are not well understood. Here we report that specific alterations in social and communication behaviors in mice occur as a result of loss of the EPAC2 gene, which encodes a protein kinase A-independent cAMP target. Epac2-deficient mice exhibited robust deficits in social interactions and ultrasonic vocalizations, but displayed normal olfaction, working and reference memory, motor abilities, anxiety, and repetitive behaviors. Epac2-deficient mice displayed abnormal columnar organization in the anterior cingulate cortex, a region implicated in social behavior in humans, but not in somatosensory cortex. In vivo two-photon imaging revealed reduced dendritic spine motility and density on cortical neurons in Epac2-deficient mice, indicating deficits at the synaptic level. Together, these findings provide novel insight into the molecular and cellular substrates of social and communication behavior.
C1 [Srivastava, Deepak P.; Jones, Kelly A.; Woolfrey, Kevin M.; Russell, Theron A.; Kalmbach, Abigail; Wokosin, David; Waters, Jack; Penzes, Peter] Northwestern Univ, Feinberg Sch Med, Dept Physiol, Chicago, IL 60611 USA.
[Penzes, Peter] Northwestern Univ, Feinberg Sch Med, Dept Psychiat & Behav Sci, Chicago, IL 60611 USA.
[Penzes, Peter] Northwestern Univ, Feinberg Sch Med, Lurie Canc Res Ctr, Chicago, IL 60611 USA.
[Burgdorf, Jeffrey; Moskal, Joseph R.] Northwestern Univ, Dept Biomed Engn, Evanston, IL 60208 USA.
[Lee, Hyerin; Yang, Connie; Bradberry, Mazdak M.] Northwestern Univ, Weinberg Coll Arts & Sci, Evanston, IL 60208 USA.
[Casanova, Manuel F.] Univ Louisville, Dept Psychiat, Louisville, KY 40292 USA.
[Srivastava, Deepak P.] Kings Coll London, Inst Psychiat, James Black Ctr, Ctr Cellular Basis Behav, London SE5 8AF, England.
[Srivastava, Deepak P.] Kings Coll London, Inst Psychiat, James Black Ctr, Dept Neurosci, London SE5 8AF, England.
RP Penzes, P (reprint author), Northwestern Univ, Feinberg Sch Med, Dept Physiol, Chicago, IL 60611 USA.
EM p-penzes@northwestern.edu
RI Moskal, Joseph/B-7628-2009
FU National Alliance for Autism Research; National Alliance for Research on
Schizophrenia and Depression (NARSAD); Alzheimer's Association; Brain
Research Foundation [BRF SG 2010-13]; National Institutes of Health
(NIH) [2R01MH071316, 1R01MH097216]; American Heart Association (AHA);
Royal Society; NIH [F31MH085362, 1R01MH094835, 1R01MH-086784,
1R01HD-065279, 5R21MH085117-02]; Ralph and Marian Falk Medical Research
Trust Chicago, IL; National Institute of Neurological Disorders and
Stroke [P30NS054850]; Northwestern University Behavioral Phenotyping
Core
FX This work was supported by the National Alliance for Autism Research,
the National Alliance for Research on Schizophrenia and Depression
(NARSAD), the Alzheimer's Association, Brain Research Foundation, and
National Institutes of Health (NIH) Grants 2R01MH071316 and 1R01MH097216
(P. P.); a pre-doctoral American Heart Association (AHA) fellowship (K.
M. W.); a post-doctoral AHA fellowship, a NARSAD Young Investigators
award, and a Royal Society International Exchange Grant (D. P. S.); NIH
Grant F31MH085362 (K.A.J.); NIH Grant 1R01MH094835 (J.B.); The Ralph and
Marian Falk Medical Research Trust Chicago, IL (J.R.M.); NIH Grants
1R01MH-086784 and 1R01HD-065279 (M. F. C.); NIH Grant 5R21MH085117-02
and a Brain Research Foundation Grant BRF SG 2010-13 (J.W.); and a
National Institute of Neurological Disorders and Stroke Grant to the
Northwestern University Multi-Photon Core (P30NS054850). EPAC2-null mice
were generated by Professor Susumu Seino (Kobe University Graduate
School of Medicine). This work was supported by the Northwestern
University Behavioral Phenotyping Core, and we thank John Linardakis for
assistance with behavioral testing. We thank Katharine R. Smith and
Natalie C. Tronson for critical reading of this manuscript.
CR Bacchelli E, 2003, MOL PSYCHIATR, V8, P916, DOI 10.1038/sj.mp.4001340
Bangash MA, 2011, CELL, V145, P758, DOI 10.1016/j.cell.2011.03.052
Benes FM, 2001, BIOL PSYCHIAT, V50, P395, DOI 10.1016/S0006-3223(01)01084-8
Burgdorf J, 2007, BEHAV BRAIN RES, V182, P274, DOI 10.1016/j.bbr.2007.03.010
Buxbaum JD, 2001, AM J HUM GENET, V68, P1514, DOI 10.1086/320588
Buxhoeveden DP, 2000, J NEUROSCI METH, V97, P7, DOI 10.1016/S0165-0270(99)00192-2
Cahill ME, 2009, P NATL ACAD SCI USA, V106, P13058, DOI 10.1073/pnas.0904636106
Casanova MF, 2009, J ANAT, V214, P226, DOI 10.1111/j.1469-7580.2008.01027.x
Casanova MF, 2002, ANN NEUROL, V52, P108, DOI 10.1002/ana.10226
Casanova MF, 2003, NEUROSCIENTIST, V9, P496, DOI 10.1177/1073858403253552
Chklovskii DB, 2004, NEURON, V43, P609, DOI 10.1016/S0896-6273(04)00498-2
Cook MN, 2002, BEHAV GENET, V32, P113, DOI 10.1023/A:1015249706579
Di Rosa E, 2008, J CLIN NEUROSCI, V15, P1389, DOI 10.1016/j.jocn.2008.01.018
Feng GP, 2000, NEURON, V28, P41, DOI 10.1016/S0896-6273(00)00084-2
Fischer J, 2011, GENES BRAIN BEHAV, V10, P17, DOI 10.1111/j.1601-183X.2010.00610.x
Gelinas JN, 2008, LEARN MEMORY, V15, P403, DOI 10.1101/lm.830008
GOLDMANRAKIC PS, 1995, NEURON, V14, P477, DOI 10.1016/0896-6273(95)90304-6
Hettinger JA, 2008, AM J MED GENET B, V147B, P628, DOI 10.1002/ajmg.b.30655
Hines RM, 2008, J NEUROSCI, V28, P6055, DOI 10.1523/JNEUROSCI.0032-08.2008
Holtmaat A, 2006, NATURE, V441, P979, DOI 10.1038/nature04783
Holy TE, 2005, PLOS BIOL, V3, P2177, DOI 10.1371/journal.pbio.0030386
Jamain S, 2003, NAT GENET, V34, P27, DOI 10.1038/ng1136
Jurgens U, 2009, J VOICE, V23, P1, DOI 10.1016/j.jvoice.2007.07.005
Kawasaki H, 1998, SCIENCE, V282, P2275, DOI 10.1126/science.282.5397.2275
Kelley DJ, 2008, NEUROSCI BIOBEHAV R, V32, P1533, DOI 10.1016/j.neubiorev.2008.06.005
Kelly MP, 2009, MOL PSYCHIATR, V14, P398, DOI 10.1038/mp.2008.124
Marshall CR, 2008, AM J HUM GENET, V82, P477, DOI 10.1016/j.ajhg.2007.12.009
Morozov A, 2003, NEURON, V39, P309, DOI 10.1016/S0896-6273(03)00404-5
Moy SS, 2007, BEHAV BRAIN RES, V176, P4, DOI 10.1016/j.bbr.2006.07.030
Muller JM, 2009, DEV PSYCHOBIOL, V51, P158, DOI 10.1002/dev.20355
Nestler EJ, 2002, NEURON, V34, P13, DOI 10.1016/S0896-6273(02)00653-0
Oblak AL, 2011, AUTISM RES, V4, P200, DOI 10.1002/aur.188
Peca J, 2011, NATURE, V472, P437, DOI 10.1038/nature09965
Radyushkin K, 2009, GENES BRAIN BEHAV, V8, P416, DOI 10.1111/j.1601-183X.2009.00487.x
Rakic P, 2009, NAT REV NEUROSCI, V10, P724, DOI 10.1038/nrn2719
Rushworth MFS, 2007, TRENDS COGN SCI, V11, P168, DOI 10.1016/j.tics.2007.01.004
Shao YJ, 2002, AM J HUM GENET, V70, P1058, DOI 10.1086/339765
Shibasaki T, 2007, P NATL ACAD SCI USA, V104, P19333, DOI 10.1073/pnas.0707054104
Silva AJ, 1999, BRAIN RES BULL, V50, P441, DOI 10.1016/S0361-9230(99)00124-0
Silverman JL, 2010, NAT REV NEUROSCI, V11, P490, DOI 10.1038/nrn2851
Srivastava D. P., 2011, JOVE-J VIS EXP, V53, pe2794, DOI 10.3791/2794
Srivastava DP, 2012, PLOS BIOL, V10, DOI 10.1371/journal.pbio.1001350
Tardito D, 2001, EUR NEUROPSYCHOPHARM, V11, P221, DOI 10.1016/S0924-977X(01)00088-8
Torii M, 2009, NATURE, V461, P524, DOI 10.1038/nature08362
Ulucan C, 2007, AM J PHYSIOL-HEART C, V293, pH1662, DOI 10.1152/ajpheart.00159.2007
Wang HF, 2008, BIORESOURCES, V3, P3
Wang XM, 2011, HUM MOL GENET, V20, P3093, DOI 10.1093/hmg/ddr212
Woolfrey KM, 2009, NAT NEUROSCI, V12, P1275, DOI 10.1038/nn.2386
Yang M, 2012, PSYSL BEHAV, DOI [10.1016/jphysbeh.2011.12.025, DOI 10.1016/JPHYSBEH.2011.12.025]
Yang Y, 2012, NEURON, V73, P774, DOI 10.1016/j.neuron.2012.02.003
NR 50
TC 10
Z9 10
PU SOC NEUROSCIENCE
PI WASHINGTON
PA 11 DUPONT CIRCLE, NW, STE 500, WASHINGTON, DC 20036 USA
SN 0270-6474
J9 J NEUROSCI
JI J. Neurosci.
PD AUG 22
PY 2012
VL 32
IS 34
BP 11864
EP 11878
DI 10.1523/JNEUROSCI.1349-12.2012
PG 15
WC Neurosciences
SC Neurosciences & Neurology
GA 997BZ
UT WOS:000308140500031
PM 22915127
ER
PT J
AU Xu, X
Xu, Q
Zhang, Y
Zhang, XD
Cheng, TL
Wu, BB
Ding, YH
Lu, P
Zheng, JJ
Zhang, M
Qiu, ZL
Yu, X
AF Xu, Xiu
Xu, Qiong
Zhang, Ying
Zhang, Xiaodi
Cheng, Tianlin
Wu, Bingbing
Ding, Yanhua
Lu, Ping
Zheng, Jingjing
Zhang, Min
Qiu, Zilong
Yu, Xiang
TI A case report of Chinese brothers with inherited MECP2-containing
duplication: autism and intellectual disability, but not seizures or
respiratory infections
SO BMC MEDICAL GENETICS
LA English
DT Article
DE MECP2; Autism; ASD; CNV; Chinese patients
ID SEVERE MENTAL-RETARDATION; CREATINE TRANSPORTER DEFICIENCY; CPG-BINDING
PROTEIN-2; GENE COPY NUMBER; RETT-SYNDROME; MECP2 GENE; NEUROLOGICAL
SYMPTOMS; RECURRENT INFECTIONS; XQ28; DISORDER
AB Background: Autistic spectrum disorders (ASDs) are a family of neurodevelopmental disorders with strong genetic components. Recent studies have shown that copy number variations in dosage sensitive genes can contribute significantly to these disorders. One such gene is the transcription factor MECP2, whose loss of function in females results in Rett syndrome, while its duplication in males results in developmental delay and autism.
Case presentation: Here, we identified a Chinese family with two brothers both inheriting a 2.2 Mb MECP2 containing duplication (151,369,305 - 153,589,577) from their mother. In addition, both brothers also had a 213.7 kb duplication on Chromosome 2, inherited from their father. The older brother also carried a 48.4 kb duplication on Chromosome 2 inherited from the mother, and a 8.2 kb deletion at 11q13.5 inherited from the father. Based on the published literature, MECP2 is the most autism-associated gene among the identified CNVs. Consistently, the boys displayed clinical features in common with other patients carrying MECP2 duplications, including intellectual disability, autism, lack of speech, slight hypotonia and unsteadiness of movement. They also had slight dysmorphic features including a depressed nose bridge, large ears and midface hypoplasia. Interestingly, they did not exhibit other clinical features commonly observed in American-European patients with MECP2 duplication, including recurrent respiratory infections and epilepsy.
Conclusions: To our knowledge, this is the first identification and characterization of Chinese Han patients with MECP2-containing duplications. Further cases are required to determine if the above described clinical differences are due to individual variations or related to the genetic background of the patients.
C1 [Xu, Xiu; Xu, Qiong; Zhang, Ying; Wu, Bingbing; Ding, Yanhua; Lu, Ping] Fudan Univ, Childrens Hosp, Dept Child Healthcare, Shanghai 200433, Peoples R China.
[Zhang, Xiaodi; Cheng, Tianlin; Zheng, Jingjing; Zhang, Min; Qiu, Zilong; Yu, Xiang] Chinese Acad Sci, Inst Neurosci, Shanghai, Peoples R China.
[Zhang, Xiaodi; Cheng, Tianlin; Zheng, Jingjing; Zhang, Min; Qiu, Zilong; Yu, Xiang] Chinese Acad Sci, Shanghai Inst Biol Sci, State Key Lab Neurosci, Shanghai, Peoples R China.
[Zhang, Xiaodi; Cheng, Tianlin; Zheng, Jingjing] Chinese Acad Sci, Grad Sch, Shanghai, Peoples R China.
RP Xu, X (reprint author), Fudan Univ, Childrens Hosp, Dept Child Healthcare, Shanghai 200433, Peoples R China.
EM xuxiu@shmu.edu.cn; yuxiang@ion.ac.cn
FU Ministry of Science and Technology [2011CBA00400]; National Science
Foundation of China [31021063, 31125015]; Chinese Academy of Sciences;
Shanghai Municipal Health Bureau [GWDTR201220, 12GWZX0301]
FX We thank all the children and their families for participating in this
study, and thank Ms. Congxiao Yu (Wenmiao Kindergarten, Shanghai) for
support in organizing the control subjects for the CGH analysis of this
study. We thank Dr. Feng Zhang from Fudan University for advice on CNV
analysis. This study was supported by 973 grant 2011CBA00400 from the
Ministry of Science and Technology (to XX, ZQ, and XY), grants 31021063
and 31125015 from the National Science Foundation of China (to XY), the
Hundred Talent Program from the Chinese Academy of Sciences (to ZQ), and
grants GWDTR201220 and 12GWZX0301 from the Shanghai Municipal Health
Bureau (to XX).
CR Abrahams BS, 2008, NAT REV GENET, V9, P341, DOI 10.1038/nrg2346
Amir RE, 1999, NAT GENET, V23, P185
Association AP, 1994, DIAGN STAT MAN MENT
BAILEY A, 1995, PSYCHOL MED, V25, P63
Belligni EF, 2010, AM J MED GENET A, V152A, P1591, DOI 10.1002/ajmg.a.33311
Breman AM, 2010, EUR J HUM GENET, V19, P409, DOI DOI 10.1038/EJHG.2010.195
Bucan M, 2009, PLOS GENET, V5, DOI 10.1371/journal.pgen.1000536
Budisteanu M, 2011, EUR CHILD ADOLES PSY, V20, P373, DOI 10.1007/s00787-011-0184-2
Campos M, 2010, J MOL NEUROSCI, V41, P105, DOI 10.1007/s12031-009-9296-2
Carvalho CMB, 2009, HUM MOL GENET, V18, P2188, DOI 10.1093/hmg/ddp151
Chen RZ, 2001, NAT GENET, V27, P327, DOI 10.1038/85906
Clayton-Smith J, 2009, EUR J HUM GENET, V17, P434, DOI 10.1038/ejhg.2008.192
Collins AL, 2004, HUM MOL GENET, V13, P2679, DOI 10.1093/hmg/ddh282
Cooper GM, 2011, NAT GENET, V43, P838, DOI 10.1038/ng.909
del Gaudio D, 2006, GENET MED, V8, P784, DOI 10.1097/01.gim.0000250502.28516.3c
DEROGATIS L R, 1973, Psychopharmacology Bulletin, V9, P13
Du RQ, 2012, J HUM GENET, V57, P545, DOI 10.1038/jhg.2012.66
Echenne B, 2009, PEDIATR NEUROL, V41, P187, DOI 10.1016/j.pediatrneurol.2009.03.012
Folstein SE, 2001, NAT REV GENET, V2, P943, DOI 10.1038/35103559
Freitag CM, 2007, MOL PSYCHIATR, V12, P2, DOI 10.1038/sj.mp.4001896
Friez MJ, 2006, PEDIATRICS, V118, pE1687, DOI 10.1524/peds.2006-0395
Gong YX, 1992, WECHSLER ADULT INTEL
Gottipati S, 2008, CELL SIGNAL, V20, P269, DOI 10.1016/j.cellsig.2007.08.009
Guy J, 2001, NAT GENET, V27, P322, DOI 10.1038/85899
Hurley RSE, 2007, J AUTISM DEV DISORD, V37, P1679, DOI 10.1007/s10803-006-0299-3
Kirk EP, 2009, CLIN GENET, V75, P301, DOI 10.1111/j.1399-0004.2008.01102.x
Lord C, 1999, AUSTISM DIAGNOSTIC O
Lugtenberg D, 2009, EUR J HUM GENET, V17, P444, DOI 10.1038/ejhg.2008.208
Lugtenberg D, 2006, J MED GENET, V43, P362, DOI 10.1136/jmg.2005.036178
Luikenhuis S, 2004, P NATL ACAD SCI USA, V101, P6033, DOI 10.1073/pnas.0401626101
Meins M, 2005, J MED GENET, V42, DOI 10.1136/jmg.2004.023804
Moretti P, 2006, CURR OPIN GENET DEV, V16, P276, DOI 10.1016/j.gde.2006.04.009
Newmeyer A, 2007, NEUROPEDIATRICS, V38, P310, DOI 10.1055/s-2008-1065353
Nomura Y, 2005, BRAIN DEV-JPN, V27, pS35, DOI 10.1016/j.braindev.2005.03.017
Pizzarelli R, 2011, NEURAL PLAST, DOI 10.1155/2011/297153
Poo-Arguelles P, 2006, J INHERIT METAB DIS, V29, P220, DOI 10.1007/s10545-006-0212-4
Prescott TE, 2009, CLIN DYSMORPHOL, V18, P78, DOI 10.1097/MCD.0b013e32831e19cd
Ramocki MB, 2010, AM J MED GENET A, V152A, P1079, DOI 10.1002/ajmg.a.33184
Ramocki MB, 2009, ANN NEUROL, V66, P771, DOI 10.1002/ana.21715
Reardon W, 2010, EUR J PEDIATR, V169, P941, DOI 10.1007/s00431-010-1144-4
Rett A, 1977, HDB CLIN NEUROLOGY, P305
Sanlaville D, 2005, EUR J HUM GENET, V13, P579, DOI 10.1038/sj.ejhg.5201384
Shahbazian MD, 2002, NEURON, V35, P243, DOI 10.1016/S0896-6273(02)00768-7
Smyk M, 2008, AM J MED GENET B, V147B, P799, DOI 10.1002/ajmg.b.30683
Toro R, 2010, TRENDS GENET, V26, P363, DOI 10.1016/j.tig.2010.05.007
Van Esch H, 2005, AM J HUM GENET, V77, P442, DOI 10.1086/444549
Velinov M, 2009, CLIN DYSMORPHOL, V18, P9, DOI 10.1097/MCD.0b013e3283157cad
Wang ZY, 1984, SHANGHAI ARCH PSYCHI, V2, P68
Wechsler D, 1981, WECHSLER ADULT INTEL
Xi CY, 2011, J CHILD NEUROL, V26, P570, DOI 10.1177/0883073810387138
Xu LM, 2012, NUCLEIC ACIDS RES, V40, pD1016, DOI 10.1093/nar/gkr1145
Zoghbi HY, 2012, CSH PERSPECT BIOL, V4, P3
NR 52
TC 4
Z9 5
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1471-2350
J9 BMC MED GENET
JI BMC Med. Genet.
PD AUG 21
PY 2012
VL 13
AR 75
DI 10.1186/1471-2350-13-75
PG 8
WC Genetics & Heredity
SC Genetics & Heredity
GA 045SY
UT WOS:000311718300001
PM 22909152
ER
PT J
AU Sutcliffe, AG
Barnes, J
Belsky, J
Gardiner, J
Melhuish, E
AF Sutcliffe, Alastair G.
Barnes, Jacqueline
Belsky, Jay
Gardiner, Julian
Melhuish, Edward
TI The health and development of children born to older mothers in the
United Kingdom: observational study using longitudinal cohort data
SO BRITISH MEDICAL JOURNAL
LA English
DT Article
ID YOUNG MATERNAL AGE; PATERNAL AGE; RISK; SCHIZOPHRENIA; OUTCOMES; AUTISM
AB Objective To assess relations between children's health and development and maternal age.
Design Observational study of longitudinal cohorts.
Setting Millennium Cohort Study (a random sample of UK children) and the National Evaluation of Sure Start study (a random sample of children in deprived areas in England), 2001 to 2007.
Participants 31 257 children at age 9 months, 24 781 children at age 3 years, and 22 504 at age 5 years.
Main outcome measures Childhood unintentional injuries and hospital admissions (aged 9 months, 3 years, and 5 years), immunisations (aged 9 months and 3 years), body mass index, language development, and difficulties with social development (aged 3 and 5 years).
Results Associations were independent of personal and family characteristics and parity. The risk of children having unintentional injuries requiring medical attention or being admitted to hospital both declined with increasing maternal age. For example, at three years the risk of unintentional injuries declined from 36.6% for mothers aged 20 to 28.6% for mothers aged 40 and hospital admissions declined, respectively, from 27.1% to 21.6%. Immunisation rates at nine months increased with maternal age from 94.6% for mothers aged 20 to 98.1% for mothers aged 40. At three years, immunisation rates reached a maximum, at 81.3% for mothers aged 27, being lower for younger and older mothers. This was linked to rates for the combined measles, mumps, and rubella immunisation because excluding these resulted in no significant relation with maternal age. An increase in overweight children at ages 3 and 5 years associated with increasing maternal age was eliminated once maternal body mass index was included as a covariate. Language development was associated with improvements with increasing maternal age, with scores for children of mothers aged 20 being lower than those of children of mothers aged 40 by 0.21 to 0.22 standard deviations at ages 3 and 4 years. There were fewer social and emotional difficulties associated with increasing maternal age. Children of teenage mothers had more difficulties than children of mothers aged 40 (difference 0.28 SD at age 3 and 0.16 SD at age 5).
Conclusion Increasing maternal age was associated with improved health and development for children up to 5 years of age.
C1 [Barnes, Jacqueline; Belsky, Jay; Gardiner, Julian; Melhuish, Edward] Univ London, Inst Study Children Families & Social Issues, London WC1E 7HX, England.
[Sutcliffe, Alastair G.] UCL, Inst Child Hlth, London WC1E 6BT, England.
[Belsky, Jay] Univ Calif Davis, Davis, CA 95616 USA.
RP Melhuish, E (reprint author), Univ London, Inst Study Children Families & Social Issues, London WC1E 7HX, England.
EM e.melhuish@bbk.ac.uk
FU Wellcome Trust
FX This research was funded by the Wellcome Trust through a grant entitled
"Health of children born to older mothers"; the funding body had no
involvement in the design and conduct of the study; collection,
management, analysis, and interpretation of the data; and preparation,
review, or approval of the manuscript. All authors are independent of
the funding agency.
CR Berryman J. C., 1995, OLDER MOTHERS CONCEP
Botting B., 1998, POPULATION TRENDS, V93, P19
Caplan AL, 2010, SEMIN REPROD MED, V28, P281, DOI 10.1055/s-0030-1255175
Centers for Disease Control and Prevention, 2007, MEASL MUMPS RUB MMR
Centers for Disease Control and Prevention, 2010, PERC DAT FIL LMS VAL
Croen LA, 2007, ARCH PEDIAT ADOL MED, V161, P334, DOI 10.1001/archpedi.161.4.334
Dex S., 2004, MILLENNIUM COHORT ST
Eisenberg DTA, 2012, P NATL ACAD SCI US
Elliott C. D., 1996, BRIT ABILITY SCALES
Fergusson DM, 1999, J CHILD PSYCHOL PSYC, V40, P479, DOI 10.1111/1469-7610.00464
FRASER AM, 1995, NEW ENGL J MED, V332, P1113, DOI 10.1056/NEJM199504273321701
Gilbert William, 2004, J Matern Fetal Neonatal Med, V16, P265, DOI 10.1080/14767050400018064
Goodman R, 1997, J CHILD PSYCHOL PSYC, V38, P581, DOI 10.1111/j.1469-7610.1997.tb01545.x
Hesterberg T., 1998, 75 MATHSOFT
Honaker J, 2010, AMELIA 2 R PACKAGE
Irwin LG, 2011, EARLY CHILD DEV POWE
Kiernan K. E., 2009, MATERNAL INDICATORS
Martin JA, 2004, NATL VITAL STAT REPO, V55
Melhuish E, 2008, LANCET, V372, P1641, DOI 10.1016/S0140-6736(08)61687-6
Moffitt TE, 2002, J CHILD PSYCHOL PSYC, V43, P727, DOI 10.1111/1469-7610.00082
Noble M., 2000, MEASURING MULTIPLE D
Office for National Statistics, 2007, SER FM1, V35
Phipps MG, 2002, OBSTET GYNECOL, V100, P481, DOI 10.1016/S0029-7844(02)02172-5
Plewis I., 2007, MILLENNIUM COHORT ST, V4th
Rubin D., 1987, MULTIPLE IMPUTATION
Statistics New Zealand, 2012, BIRTHS DEATHS YEAR E
Sutcliffe A, 2009, REPROD AGEING, P173
Venables WN, MASS R PACKAGE
Vohr BR, 2009, J PEDIATR-US, V154, P498, DOI 10.1016/j.jpeds.2008.10.044
Weiser M, 2008, SCHIZOPHRENIA BULL, V34, P1042, DOI 10.1093/schbul/sbn109
Zammit S, 2003, BRIT J PSYCHIAT, V183, P405, DOI 10.1192/bjp.183.5.405
NR 31
TC 7
Z9 7
PU B M J PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 1756-1833
J9 BRIT MED J
JI Br. Med. J.
PD AUG 21
PY 2012
VL 345
AR e5116
DI 10.1136/bmj.e5116
PG 10
WC Medicine, General & Internal
SC General & Internal Medicine
GA 996GP
UT WOS:000308073200001
PM 22915663
ER
PT J
AU Yamada, A
Kato, M
Suzuki, M
Suzuki, M
Watanabe, N
Akechi, T
Furukawa, TA
AF Yamada, Atsurou
Kato, Misuzu
Suzuki, Miyoshi
Suzuki, Masako
Watanabe, Norio
Akechi, Tatsuo
Furukawa, Toshi A.
TI Quality of life of parents raising children with pervasive developmental
disorders
SO BMC PSYCHIATRY
LA English
DT Article
ID AUTISM SPECTRUM DISORDER; HIGH-FUNCTIONING AUTISM; SF-36 HEALTH SURVEY;
DOUBLE ABCX MODEL; SOCIAL SUPPORT; FAMILY CAREGIVERS; ASPERGER-SYNDROME;
STRESS PROFILES; MENTAL-HEALTH; MOTHERS
AB Background: It has been reported that parents of children with pervasive developmental disorders (PDDs) face higher levels of stress. The aims of the present study were; (i) to evaluate the quality of life (QOL) of parents caring for their children with PDDs, and (ii) to explore the correlates of their QOL.
Methods: A consecutive sample of parents of children with PDDs aged 6 to 15 were approached. The MOS 36-item Short-Form Health Survey (SF-36) was used to measure the QOL of the parents by eight subscales and two summary measures. Parents' personality and marital relationships were assessed with the NEO Five Factor Inventory and the Intimate Bond Measure, respectively. We characterized the parents' SF-36 profiles in comparison with the national normative scores and explored variables which correlated with their summary measures.
Results: Participants were 147 mothers and 122 fathers of 158 children with PDDs. Mothers had significantly lower scores in the areas of Role Physical (RP) Social functioning (SF), General health perceptions (GH), Vitality (VT), Role emotional (RE) and Mental Health (MH) than those among the general female population. The maternal mental component summary (MCS) was also significantly lower, but maternal physical component summary (PCS) and paternal PCS and MCS scores were not lower. Maternal PCS and MCS scores were both significantly associated with the high Care and the low Control scores, but regarding fathers only the paternal PCS scores were significantly associated with the low Control scores. Maternal PCS and MCS and paternal MCS scores were significantly associated with the high Agreeableness scores and the low Neuroticism scores. Multiple regressions have shown that Neuroticism was significantly related to the low MCS scores of mothers and fathers. Next, Care was related to maternal high PCS, and Control was related to maternal low MCS and paternal low PCS.
Conclusions: The mothers of children with PDDs had lower QOL scores than those of the Japanese general population especially in mental domains. Impairment of the maternal QOL is significantly associated with the personality tendency of the parents and relationships with their partners.
C1 [Yamada, Atsurou; Suzuki, Masako; Watanabe, Norio; Akechi, Tatsuo] Nagoya City Univ, Grad Sch Med Sci, Dept Psychiat & Cognit Behav Med, Mizuho Ku, Nagoya, Aichi, Japan.
[Kato, Misuzu] Childrens Mental & Phys Dev Ctr, Toyohashi, Aichi, Japan.
[Suzuki, Miyoshi] Iwanishi Nursery Sch, Toyohashi, Aichi, Japan.
[Furukawa, Toshi A.] Kyoto Univ, Dept Hlth Promot & Human Behav Cognit Behav Med, Grad Sch Med, Sch Publ Hlth,Sakyo Ku, Konoe, Kyoto, Japan.
RP Yamada, A (reprint author), Nagoya City Univ, Grad Sch Med Sci, Dept Psychiat & Cognit Behav Med, Mizuho Ku, Mizuho Cho, Nagoya, Aichi, Japan.
EM atsurou.yamada@mbr.nifty.com
CR Allik H, 2006, HEALTH QUAL LIFE OUT, V4, DOI 10.1186/1477-7525-4-1
American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th
Benjak T, 2009, CROAT MED J, V50, P403, DOI 10.3325/cmj.2009.50.403
BRISTOL MM, 1987, J AUTISM DEV DISORD, V17, P469, DOI 10.1007/BF01486964
BRISTOL MM, 1988, DEV PSYCHOL, V24, P441, DOI 10.1037/0012-1649.24.3.441
Cappe E, 2011, QUAL LIFE RES, V20, P1279, DOI 10.1007/s11136-011-9861-3
Doo S, 2006, DEV MED CHILD NEUROL, V48, P650, DOI 10.1017/S001216220600137X
Dumas J. E., 1991, EXCEPTIONALITY, V2, P97, DOI [10.1080/09362839109524770, DOI 10.1080/09362839109524770]
Dunn ME, 2001, COMMUNITY MENT HLT J, V37, P39, DOI 10.1023/A:1026592305436
Ekas NV, 2010, J AUTISM DEV DISORD, V40, P1274, DOI 10.1007/s10803-010-0986-y
Ekas NV, 2009, J AUTISM DEV DISORD, V39, P706, DOI 10.1007/s10803-008-0673-4
FACTOR DC, 1990, J AUTISM DEV DISORD, V20, P139, DOI 10.1007/BF02206863
FREEMAN NL, 1991, J CHILD PSYCHOL PSYC, V32, P1025, DOI 10.1111/j.1469-7610.1991.tb01927.x
Fukuhara S., 2004, MANUAL SF 36V2 JAPAN
Fukuhara S, 1998, J CLIN EPIDEMIOL, V51, P1045, DOI 10.1016/S0895-4356(98)00096-1
Fukuhara S, 1998, J CLIN EPIDEMIOL, V51, P1037, DOI 10.1016/S0895-4356(98)00095-X
Furukawa TA, 2002, SOC PSYCH PSYCH EPID, V37, P164, DOI 10.1007/s001270200010
GILL MJ, 1991, J AUTISM DEV DISORD, V21, P407, DOI 10.1007/BF02206867
Gray David E., 1992, Australia and New Zealand Journal of Developmental Disabilities, V18, P83
Gray DE, 2003, SOC SCI MED, V56, P631, DOI 10.1016/S0277-9536(02)00059-X
Hastings RP, 2003, J INTELL DISABIL RES, V47, P231, DOI 10.1046/j.1365-2788.2003.00485.x
Hastings RP, 2005, J AUTISM DEV DISORD, V35, P635, DOI 10.1007/s10803-005-0007-8
Holroyd J., 1974, J COMMUNITY PSYCHOL, V2, P92, DOI 10.1002/1520-6629(197401)2:1<92::AID-JCOP2290020133>3.0.CO;2-A
Ikuzawa M, 2002, MANUAL KYOTO SCALE P
KOEGEL RL, 1992, J AUTISM DEV DISORD, V22, P205, DOI 10.1007/BF01058151
KONSTANTAREAS MM, 1989, J CHILD PSYCHOL PSYC, V30, P459, DOI 10.1111/j.1469-7610.1989.tb00259.x
KONSTANTAREAS MM, 1992, J MARRIAGE FAM, V54, P153, DOI 10.2307/353283
Lee LC, 2008, J AUTISM DEV DISORD, V38, P1147, DOI 10.1007/s10803-007-0491-0
Little Liza, 2002, Pediatr Nurs, V28, P565
MOES D, 1992, PSYCHOL REP, V71, P1272, DOI 10.2466/PR0.71.8.1272-1274
Montes G, 2007, PEDIATRICS, V119, pE1040, DOI 10.1542/peds.2006-2819
Mugno D, 2007, HEALTH QUAL LIFE OUT, V5, DOI 10.1186/1477-7525-5-22
Olsson MB, 2001, J INTELL DISABIL RES, V45, P535, DOI 10.1046/j.1365-2788.2001.00372.x
Pakenham KI, 2005, AUTISM, V9, P191, DOI 10.1177/1362361305049033
Shu BC, 2009, AUTISM, V13, P81, DOI 10.1177/1362361307098517
Shu BC, 2005, J INTELL DISABIL RES, V49, P47, DOI 10.1111/j.1365-2788.2005.00661.x
Siman-Tov A, 2011, J AUTISM DEV DISORD, V41, P879, DOI 10.1007/s10803-010-1112-x
SPSS Inc., 2008, SPSS WIND VERS 17 0
van Straten A, 2007, QUAL LIFE RES, V16, P1, DOI 10.1007/s11136-006-9124-x
Wechsler D., 1991, MANUAL WECHSLER INTE
Wechsler D, 1998, JAPANESE VERSION MAN
Weiss MJ, 2002, AUTISM, V6, P115, DOI 10.1177/1362361302006001009
WEISS SJ, 1991, CHILD PSYCHIAT HUM D, V21, P203, DOI 10.1007/BF00705906
WILHELM K, 1988, PSYCHOL MED, V18, P225
Wingate M., 2012, MMWR SURVEILL SUMM, V61, P1
WOLF LC, 1989, J AUTISM DEV DISORD, V19, P157, DOI 10.1007/BF02212727
Yamada A, 2007, PSYCHIAT CLIN NEUROS, V61, P651, DOI 10.1111/j.1440-1819.2007.01736.x
Yoshimura K, 2001, PSYCHOL REP, V88, P443, DOI 10.2466/PR0.88.2.443-449
NR 48
TC 6
Z9 6
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1471-244X
J9 BMC PSYCHIATRY
JI BMC Psychiatry
PD AUG 20
PY 2012
VL 12
AR 119
DI 10.1186/1471-244X-12-119
PG 8
WC Psychiatry
SC Psychiatry
GA 028RB
UT WOS:000310438900001
PM 22906177
ER
PT J
AU Mostafa, GA
Al-Ayadhi, LY
AF Mostafa, Gehan A.
Al-Ayadhi, Laila Y.
TI Reduced serum concentrations of 25-hydroxy vitamin D in children with
autism: Relation to autoimmunity
SO JOURNAL OF NEUROINFLAMMATION
LA English
DT Article
DE Anti-myelin-associated glycoprotein antibodies; Autism; Autoimmunity;
Childhood autism rating scale; Vitamin D
ID REGULATORY T-CELLS; D DEFICIENCY; SPECTRUM DISORDERS; EGYPTIAN CHILDREN;
DISEASE SEVERITY; AUTOANTIBODIES; ANTIBODIES; ASSOCIATION; PROTEIN;
FREQUENCY
AB Background: Aside from the skeletal health affection, vitamin D deficiency has been implicated as a potential environmental factor triggering for some autoimmune disorders. Vitamin D might play a role in the regulation of the production of auto-antibodies. Immunomodulatory effects of vitamin D may act not only through modulation of T-helper cell function, but also through induction of CD4(+)CD25(high) regulatory T-cells. We are the first to investigate the relationship between serum levels of 25-hydroxy vitamin D and anti-myelin-associated glycoprotein (anti-MAG) auto-antibodies in autistic children.
Methods: Serum levels of 25-hydroxy vitamin D and anti-MAG auto-antibodies were measured in 50 autistic children, aged between 5 and 12 years, and 30 healthy-matched children. Serum 25-hydroxy vitamin D levels 10-30 ng/mL and < 10 ng/mL were defined as vitamin D insufficiency and deficiency, respectively.
Results: Autistic children had significantly lower serum levels of 25-hydroxy vitamin D than healthy children (P < 0.001) with 40% and 48% being vitamin D deficient and insufficient, respectively. Serum 25-hydroxy vitamin D had significant negative correlations with Childhood Autism Rating Scale (P < 0.001). Increased levels of serum anti-MAG auto-antibodies were found in 70% of autistic patients. Serum 25-hydroxy vitamin D levels had significant negative correlations with serum levels of anti-MAG auto-antibodies (P < 0.001).
Conclusions: Vitamin D deficiency was found in some autistic children and this deficiency may contribute to the induction of the production of serum anti-MAG auto-antibodies in these children. However, future studies looking at a potential role of vitamin D in the pathophysiology and treatment of autism are warranted.
C1 [Mostafa, Gehan A.; Al-Ayadhi, Laila Y.] King Saud Univ, AL Amodi Autism Res Chair, Autism Res & Treatment Ctr, Dept Physiol,Fac Med, Riyadh, Saudi Arabia.
[Mostafa, Gehan A.] Ain Shams Univ, Fac Med, Dept Pediat, Cairo, Egypt.
RP Mostafa, GA (reprint author), King Saud Univ, AL Amodi Autism Res Chair, Autism Res & Treatment Ctr, Dept Physiol,Fac Med, Riyadh, Saudi Arabia.
EM hafezg@softhome.net
FU King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia;
NPST, Health Research and Studies program at Kind Saud University
FX This work was financially supported by the King Abdulaziz City for
Science and Technology, Riyadh, Saudi Arabia. It was also supported by
NPST, Health Research and Studies program at Kind Saud University.
CR Al-Ayadhi LY, 2012, J NEUROINFLAMM, V9, DOI 10.1186/1742-2094-9-54
Al-Ayadhi LY, 2011, J NEUROINFLAMM, V8, DOI 10.1186/1742-2094-8-111
AL-ayadhi LY, 2011, BRAIN BEHAV IMMUN, V25, P1393, DOI 10.1016/j.bbi.2011.04.006
American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th
Antico A, 2012, AUTOIMMUN REV
Bettelli E, 2008, NATURE, V453, P1051, DOI 10.1038/nature07036
Boonstra A, 2001, J IMMUNOL, V167, P4974
Cai D, 2001, J NEUROSCI, V21, P4731
Canadian Paediatric Society, 2007, PAEDIAT CHILD HLTH, V12, P583
Cannell JJ, 2010, ACTA PAEDIATR, V99, P1128, DOI 10.1111/j.1651-2227.2010.01883.x
Cannell JJ, 2008, MED HYPOTHESES, V70, P750, DOI 10.1016/j.mehy.2007.08.016
Cannell JJ, 2008, ALTERN MED REV, V13, P6
Cantorna MT, 2004, AM J CLIN NUTR, V80, p1717S
Chambers ES, 2011, CURR ALLERGY ASTHM R, V11, P29, DOI 10.1007/s11882-010-0161-8
Cohly HHP, 2005, INT REV NEUROBIOL, V71, P317, DOI 10.1016/S0074-7742(05)71013-8
Comi AM, 1999, J CHILD NEUROL, V14, P388, DOI 10.1177/088307389901400608
Croen LA, 2005, ARCH PEDIAT ADOL MED, V159, P151, DOI 10.1001/archpedi.159.2.151
Evatt ML, 2009, NEUROLOGY, V73, P997, DOI 10.1212/WNL.0b013e3181af0b95
Eyles D.W., 2012, FRONT NEUROENDOCRINO
Grant William B, 2009, Dermatoendocrinol, V1, P223
Hamza RT, 2011, MED SCI MONITOR, V17, pCR711
Holick MF, 2008, MOL ASPECTS MED, V29, P361, DOI 10.1016/j.mam.2008.08.008
Holick MF, 2007, NEW ENGL J MED, V357, P266, DOI 10.1056/NEJMra070553
Holmes VA, 2009, BR J NUTR, V31, P1
Humble MB, 2010, J PHOTOCH PHOTOBIO B, V101, P142, DOI 10.1016/j.jphotobiol.2010.08.003
Jones AP, 2012, NUTRIENTS, V4, P13, DOI 10.3390/nu4010013
Kinney DK, 2010, MED HYPOTHESES, V74, P102, DOI 10.1016/j.mehy.2009.07.052
Kocovska E, 2012, RES DEV DISABIL, V33, P1541, DOI 10.1016/j.ridd.2012.02.015
Levenson CW, 2008, NUTR REV, V66, P726, DOI 10.1111/j.1753-4887.2008.00122.x
Meguid NA, 2010, J ALTERN COMPLEM MED, V16, P641, DOI 10.1089/acm.2009.0349
Mostafa GA, 2009, PEDIATR NEUROL, V40, P107, DOI 10.1016/j.pediatrneurol.2008.10.017
Mostafa GA, 2011, J NEUROINFLAMM, V8, DOI 10.1186/1742-2094-8-39
Mostafa GA, 2012, EUR J PAEDIAT NEUROL
Mostafa GA, 2008, J CHILD NEUROL, V23, P1413, DOI 10.1177/0883073808319321
Mostafa GA, 2011, J NEUROINFLAMM, V8, DOI 10.1186/1742-2094-8-180
Mostafa GA, 2011, J NEUROINFLAMM, V8, DOI 10.1186/1742-2094-8-71
Mostafa GA, 2010, J NEUROIMMUNOL, V223, P115, DOI 10.1016/j.jneuroim.2010.03.025
Mostafa GA, 2010, J CHILD NEUROL, V25, P328, DOI 10.1177/0883073809339393
Mostafa GA, 2010, J NEUROIMMUNOL, V219, P114, DOI 10.1016/j.jneuroim.2009.12.003
Schopler E, 1986, REICHLER RJ RENNER B
Singh VK, 1997, PEDIATR NEUROL, V17, P88, DOI 10.1016/S0887-8994(97)00045-3
Singh VK, 1998, CLIN IMMUNOL IMMUNOP, V89, P105, DOI 10.1006/clin.1998.4588
Steck AJ, 2006, CURR OPIN NEUROL, V19, P458, DOI 10.1097/01.wco.0000245368.36576.0d
Sternberg Z, 2012, AUTOIMMUN REV
Sweeten T.L., 2003, PEDIATRICS, V112, P420
Vignali DAA, 2008, NAT REV IMMUNOL, V8, P523, DOI 10.1038/nri2343
Vojdani A, 2002, J NEUROIMMUNOL, V129, P168, DOI 10.1016/S0165-5728(02)00180-7
Yan J, 2005, NEUROSCI LETT, V380, P37, DOI 10.1016/j.neulet.2005.01.018
Zhang HL, 2010, NEUROSCI BULL, V26, P445, DOI 10.1007/s12264-010-0731-8
NR 49
TC 16
Z9 18
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1742-2094
J9 J NEUROINFLAMM
JI J. Neuroinflamm.
PD AUG 17
PY 2012
VL 9
AR 201
DI 10.1186/1742-2094-9-201
PG 7
WC Immunology; Neurosciences
SC Immunology; Neurosciences & Neurology
GA 013WT
UT WOS:000309337400001
PM 22898564
ER
PT J
AU Yamada, T
Ohta, H
Watanabe, H
Kanai, C
Tani, M
Ohno, T
Takayama, Y
Iwanami, A
Kato, N
Hashimoto, R
AF Yamada, Takashi
Ohta, Haruhisa
Watanabe, Hiromi
Kanai, Chieko
Tani, Masayuki
Ohno, Taisei
Takayama, Yuko
Iwanami, Akira
Kato, Nobumasa
Hashimoto, Ryuichiro
TI Functional Alterations in Neural Substrates of Geometric Reasoning in
Adults with High-Functioning Autism
SO PLOS ONE
LA English
DT Article
ID WORKING-MEMORY; NEUROCOGNITIVE DEVELOPMENT; FLUID INTELLIGENCE;
CORPUS-CALLOSUM; VISUAL-SEARCH; FMRI; PERFORMANCE; TASK; SCHIZOPHRENIA;
CONNECTIVITY
AB Individuals with autism spectrum condition (ASC) are known to excel in some perceptual cognitive tasks, but such developed functions have been often regarded as "islets of abilities" that do not significantly contribute to broader intellectual capacities. However, recent behavioral studies have reported that individuals with ASC have advantages for performing Raven's (Standard) Progressive Matrices (RPM/RSPM), a standard neuropsychological test for general fluid intelligence, raising the possibility that ASC's cognitive strength can be utilized for more general purposes like novel problem solving. Here, the brain activity of 25 adults with high-functioning ASC and 26 matched normal controls (NC) was measured using functional magnetic resonance imaging (fMRI) to examine neural substrates of geometric reasoning during the engagement of a modified version of the RSPM test. Among the frontal and parietal brain regions involved in fluid intelligence, ASC showed larger activation in the left lateral occipitotemporal cortex (LOTC) during an analytic condition with moderate difficulty than NC. Activation in the left LOTC and ventrolateral prefrontal cortex (VLPFC) increased with task difficulty in NC, whereas such modulation of activity was absent in ASC. Furthermore, functional connectivity analysis revealed a significant reduction of activation coupling between the left inferior parietal cortex and the right anterior prefrontal cortex during both figural and analytic conditions in ASC. These results indicate altered pattern of functional specialization and integration in the neural system for geometric reasoning in ASC, which may explain its atypical cognitive pattern, including performance on the Raven's Matrices test.
C1 [Yamada, Takashi; Ohta, Haruhisa; Watanabe, Hiromi; Kanai, Chieko; Tani, Masayuki; Ohno, Taisei; Takayama, Yuko; Iwanami, Akira; Kato, Nobumasa; Hashimoto, Ryuichiro] Showa Univ, Sch Med, Dept Psychiat, Tokyo 142, Japan.
[Kanai, Chieko; Kato, Nobumasa; Hashimoto, Ryuichiro] Japan Sci & Technol Agcy, CREST, Tokyo, Japan.
RP Yamada, T (reprint author), Showa Univ, Sch Med, Dept Psychiat, Tokyo 142, Japan.
EM dbridges50@gmail.com
FU CREST of Japanese Science and Technology (JST); Kakenhi
FX This work was supported by CREST of Japanese Science and Technology
(JST) to NK and Grant-in-Aid for Research Activity Start-up (Kakenhi) to
RH. The funders had no role in study design, data collection and
analysis, decision to publish, or preparation of the manuscript.
CR Alexander AL, 2007, NEUROIMAGE, V34, P61, DOI 10.1016/j.neuroimage.2006.08.032
Anderson JS, 2011, CEREB CORTEX, V21, P1134, DOI 10.1093/cercor/bhq190
Barttfeld P, 2011, NEUROPSYCHOLOGIA, V49, P254, DOI 10.1016/j.neuropsychologia.2010.11.024
Bolte S, 2009, J AUTISM DEV DISORD, V39, P678, DOI 10.1007/s10803-008-0667-2
Bracci S, 2012, J NEUROPHYSIOL, V107, P1443, DOI 10.1152/jn.00619.2011
Casanova MF, 2009, PHILOS T R SOC B, V364, P1433, DOI 10.1098/rstb.2008.0331
Crone EA, 2006, P NATL ACAD SCI USA, V103, P9315, DOI 10.1073/pnas.0510088103
Crone EA, 2009, DEVELOPMENTAL SCI, V12, P55, DOI 10.1111/j.1467-7687.2008.00743.x
Dawson M, 2007, PSYCHOL SCI, V18, P657, DOI 10.1111/j.1467-9280.2007.01954.x
Desco M, 2011, NEUROIMAGE, V57, P281, DOI 10.1016/j.neuroimage.2011.03.063
Dosenbach NUF, 2010, SCIENCE, V329, P1358, DOI 10.1126/science.1194144
Fox MD, 2005, NEUROIMAGE, V25, P771, DOI 10.1016/j.neuroimage.2004.12.025
Geake JG, 2010, NEUROIMAGE, V49, P3489, DOI 10.1016/j.neuroimage.2009.09.008
Geake JG, 2005, NEUROIMAGE, V26, P555, DOI 10.1016/j.neuroimage.2005.01.035
Geschwind DH, 2007, CURR OPIN NEUROBIOL, V17, P103, DOI 10.1016/j.conb.2007.01.009
Gray JR, 2003, NAT NEUROSCI, V6, P316, DOI 10.1038/nn1014
Grill-Spector K, 2003, CURR OPIN NEUROBIOL, V13, P159, DOI 10.1016/S0959-4388(03)00040-0
Hampshire A, 2011, CEREB CORTEX, V21, P1, DOI 10.1093/cercor/bhq085
Hayashi M, 2008, BRAIN COGNITION, V66, P306, DOI 10.1016/j.bandc.2007.09.008
Johnson MR, 2006, BIOL PSYCHIAT, V60, P11, DOI 10.1016/j.biopsych.2005.11.012
Jung RE, 2007, BEHAV BRAIN SCI, V30, P135, DOI 10.1017/S0140525X07001185
Kanai C, 2012, RES AUTISM SPECT DIS, V6, P7
Keary CJ, 2009, J AUTISM DEV DISORD, V39, P834, DOI 10.1007/s10803-009-0689-4
Koch K, 2012, NEUROPSYCHOLOGIA, V50, P958, DOI 10.1016/j.neuropsychologia.2012.02.002
Konishi S, 2001, NEUROIMAGE, V13, P364, DOI 10.1006/nimg.2000.0691
Koshino H, 2005, NEUROIMAGE, V24, P810, DOI 10.1016/j.neuroimage.2004.09.028
Lynn R, 2004, WESCHLER ADULT INTEL, V32
Manoach DS, 2003, SCHIZOPHR RES, V60, P285, DOI 10.1016/S0920-9964(02)00294-3
Matsuoka K, 2006, PSYCHIAT CLIN NEUROS, V60, P332, DOI 10.1111/j.1440-1819.2006.01510.x
Mottron L, 2006, J AUTISM DEV DISORD, V36, P27, DOI 10.1007/s10803-005-0040-7
OLDFIELD RC, 1971, NEUROPSYCHOLOGIA, V9, P97, DOI 10.1016/0028-3932(71)90067-4
O'Riordan MA, 2001, J EXP PSYCHOL HUMAN, V27, P719, DOI 10.1037//0096-1523.27.3.719
Plaisted K, 1998, J CHILD PSYCHOL PSYC, V39, P777, DOI 10.1017/S0021963098002613
Prabhakaran V, 1997, COGNITIVE PSYCHOL, V33, P43, DOI 10.1006/cogp.1997.0659
Prabhakaran V, 2000, NAT NEUROSCI, V3, P85, DOI 10.1038/71156
Preusse F, 2011, FRONT HUM NEUROSCI, V5, DOI 10.3389/fnhum.2011.00022
Price CJ, 1999, HUM BRAIN MAPP, V8, P102, DOI 10.1002/(SICI)1097-0193(1999)8:2/3<102::AID-HBM6>3.0.CO;2-J
Price CJ, 2006, J MAGN RESON IMAGING, V23, P816, DOI 10.1002/jmri.20580
Ring HA, 1999, BRAIN, V122, P1305, DOI 10.1093/brain/122.7.1305
Sahyoun CP, 2010, NEUROPSYCHOLOGIA, V48, P86, DOI 10.1016/j.neuropsychologia.2009.08.013
SHAH A, 1983, J CHILD PSYCHOL PSYC, V24, P613, DOI 10.1111/j.1469-7610.1983.tb00137.x
SHAH A, 1993, J CHILD PSYCHOL PSYC, V34, P1351, DOI 10.1111/j.1469-7610.1993.tb02095.x
Soulieres I, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0025372
Soulieres I, 2009, HUM BRAIN MAPP, V30, P4082, DOI 10.1002/hbm.20831
van der Ven AHGS, 2000, PERSONALITY INDIVIDU, V29
Vincent JL, 2006, J NEUROPHYSIOL, V96, P3517, DOI 10.1152/jn.00048.2006
Wakabayashi A, 2006, J AUTISM DEV DISORD, V36, P263, DOI 10.1007/s10803-005-0061-2
NR 47
TC 2
Z9 2
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD AUG 17
PY 2012
VL 7
IS 8
AR e43220
DI 10.1371/journal.pone.0043220
PG 11
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 996DG
UT WOS:000308063700063
PM 22912831
ER
PT J
AU Farook, MF
DeCuypere, M
Hyland, K
Takumi, T
LeDoux, MS
Reiter, LT
AF Farook, M. Febin
DeCuypere, Michael
Hyland, Keith
Takumi, Toru
LeDoux, Mark S.
Reiter, Lawrence T.
TI Altered Serotonin, Dopamine and Norepinepherine Levels in 15q
Duplication and Angelman Syndrome Mouse Models
SO PLOS ONE
LA English
DT Article
ID REUPTAKE INHIBITORS; CEREBROSPINAL-FLUID; AUTISTIC DISORDER; UBIQUITIN
LIGASE; MICE; TRANSPORTER; BEHAVIOR; UBE3A; GENE; MUTATIONS
AB Childhood neurodevelopmental disorders like Angelman syndrome and autism may be the result of underlying defects in neuronal plasticity and ongoing problems with synaptic signaling. Some of these defects may be due to abnormal monoamine levels in different regions of the brain. Ube3a, a gene that causes Angelman syndrome (AS) when maternally deleted and is associated with autism when maternally duplicated has recently been shown to regulate monoamine synthesis in the Drosophila brain. Therefore, we examined monoamine levels in striatum, ventral midbrain, frontal cerebral cortex, cerebellar cortex and hippocampus in Ube3a deficient and Ube3a duplication animals. We found that serotonin (5HT), a monoamine affected in autism, was elevated in the striatum and cortex of AS mice. Dopamine levels were almost uniformly elevated compared to control littermates in the striatum, midbrain and frontal cortex regardless of genotype in Ube3a deficient and Ube3a duplication animals. In the duplication 15q autism mouse model, paternal but not maternal duplication animals showed a decrease in 5HT levels when compared to their wild type littermates, in accordance with previously published data. However, maternal duplication animals show no significant changes in 5HT levels throughout the brain. These abnormal monoamine levels could be responsible for many of the behavioral abnormalities observed in both AS and autism, but further investigation is required to determine if any of these changes are purely dependent on Ube3a levels in the brain.
C1 [Farook, M. Febin; LeDoux, Mark S.; Reiter, Lawrence T.] UTHSC, Dept Neurol, Memphis, TN USA.
[DeCuypere, Michael] UTHSC, Dept Neurosurg, Memphis, TN USA.
[Hyland, Keith] Med Neurogenet LCC, Atlanta, GA USA.
[Takumi, Toru] Hiroshima Univ, Sch Med, Hiroshima, Japan.
[LeDoux, Mark S.; Reiter, Lawrence T.] UTHSC, Dept Anat & Neurobiol, Memphis, TN USA.
[Reiter, Lawrence T.] UTHSC, Dept Pediat, Memphis, TN USA.
RP Farook, MF (reprint author), UTHSC, Dept Neurol, Memphis, TN USA.
EM lreiter@uthsc.edu
FU NIH NINDS [R01NS059902]; Core Research for Evolutional Science; Japan
Society for the Promotion of Science
FX This work was funded by NIH (http://www.nih.gov/) NINDS R01NS059902 to
LTR. TT is supported by grants from Core Research for Evolutional
Science and Japan Society for the Promotion of Science. The funders had
no role in study design, data collection and analysis, decision to
publish, or preparation of the manuscript.
CR Allensworth M, 2011, BMC GENET, V12, DOI 10.1186/1471-2156-12-7
ANDERSON GM, 1984, PSYCHIAT RES, V11, P133, DOI 10.1016/0165-1781(84)90097-0
Anderson GM, 2002, J AM ACAD CHILD PSY, V41, P1513, DOI 10.1097/01.CHI.0000024874.60748.28
Ansorge MS, 2004, SCIENCE, V306, P879, DOI 10.1126/science.1101678
Ansorge MS, 2008, J NEUROSCI, V28, P199, DOI 10.1523/JNEUROSCI.3973-07.2008
Bryant JL, 2010, EUR J NEUROSCI, V32, P41, DOI 10.1111/j.1460-9568.2010.07244.x
Cheron G, 2005, NEUROSCIENCE, V130, P631, DOI 10.1016/j.neuroscience.2004.09.013
Chugani DC, 1999, ANN NEUROL, V45, P287, DOI 10.1002/1531-8249(199903)45:3<287::AID-ANA3>3.0.CO;2-9
Cook Edwin H. Jr., 1996, Current Opinion in Pediatrics, V8, P348, DOI 10.1097/00008480-199608000-00008
Cook EH, 1997, AM J HUM GENET, V60, P928
Croonenberghs J, 2000, NEUROPSYCHOPHARMACOL, V22, P275, DOI 10.1016/S0893-133X(99)00131-1
Deneris ES, 2012, NAT NEUROSCI, V15, P519, DOI 10.1038/nn.3039
Depienne C, 2009, BIOL PSYCHIAT, V66, P349, DOI 10.1016/j.biopsych.2009.01.025
Devlin B, 2005, MOL PSYCHIATR, V10, P1110, DOI 10.1038/sj.mp.4001724
Dindot SV, 2008, HUM MOL GENET, V17, P111, DOI 10.1093/hmg/ddm288
Fang P, 1999, HUM MOL GENET, V8, P129, DOI 10.1093/hmg/8.1.129
Ferdousy F, 2011, NEUROBIOL DIS, V41, P669, DOI 10.1016/j.nbd.2010.12.001
Heck DH, 2008, HUM MOL GENET, V17, P2181, DOI 10.1093/hmg/ddn117
Hedlund PB, 2009, PSYCHOPHARMACOLOGY, V206, P345, DOI 10.1007/s00213-009-1626-0
Hogart A, 2010, NEUROBIOL DIS, V38, P181, DOI 10.1016/j.nbd.2008.08.011
Holmes A, 2001, NEUROSCI BIOBEHAV R, V25, P261, DOI 10.1016/S0149-7634(01)00012-4
HOWELLS DW, 1987, CLIN CHIM ACTA, V167, P23, DOI 10.1016/0009-8981(87)90081-7
Hranilovic D, 2009, J NEURAL TRANSM, V116, P493, DOI 10.1007/s00702-009-0192-2
Janusonis S, 2006, J NEUROCHEM, V99, P1019, DOI 10.1111/j.1471-4159.2006.04150.x
Jiang YH, 2004, CURR OPIN PEDIATR, V16, P419, DOI 10.1097/01.mop.0000133634.79661.cd
Jiang YH, 1998, NEURON, V21, P799, DOI 10.1016/S0896-6273(00)80596-6
Kalueff AV, 2010, NEUROSCI BIOBEHAV R, V34, P373, DOI 10.1016/j.neubiorev.2009.08.003
Kishino T, 1997, NAT GENET, V15, P70, DOI 10.1038/ng0197-70
Kolevzon A, 2006, J CLIN PSYCHIAT, V67, P407
Lam KSL, 2006, RES DEV DISABIL, V27, P254, DOI 10.1016/j.ridd.2005.03.003
Levy SE, 2009, LANCET, V374, P1627, DOI 10.1016/S0140-6736(09)61376-3
Makkonen I, 2008, DEV MED CHILD NEUROL, V50, P593, DOI 10.1111/j.1469-8749.2008.03027.x
Marazziti D, 2000, PHARMACOPSYCHIATRY, V33, P165, DOI 10.1055/s-2000-7588
Matsuura T, 1997, NAT GENET, V15, P74, DOI 10.1038/ng0197-74
Mukand J, 1996, ARCH PHYS MED REHAB, V77, P1309, DOI 10.1016/S0003-9993(96)90198-7
Nahas Z, 1998, J NEUROPSYCH CLIN N, V10, P453
Nakatani J, 2009, CELL, V137, P1235, DOI 10.1016/j.cell.2009.04.024
Ohta T, 1999, AM J HUM GENET, V64, P385, DOI 10.1086/302232
Pelc Karine, 2008, Neuropsychiatr Dis Treat, V4, P577
Ramamoorthy Sivapriya, 2008, Nucl Recept Signal, V6, pe006, DOI 10.1621/nrs.06006
Reiter LA, 2006, BIOORG MED CHEM LETT, V16, P5822, DOI 10.1016/j.bmcl.2006.08.066
Robinson WP, 2000, CLIN GENET, V57, P349, DOI 10.1034/j.1399-0004.2000.570505.x
Scoles HA, 2011, MOL AUTISM, V2, DOI 10.1186/2040-2392-2-19
Scoppetta M, 2005, Eur Rev Med Pharmacol Sci, V9, P343
Smith SE, 2011, SCI TRANSL MED, V3
Stecker MM, 2003, CLIN NEUROL NEUROSUR, V105, P183, DOI 10.1016/S0303-8467(03)00005-2
Sutcliffe JS, 2005, AM J HUM GENET, V77, P265, DOI 10.1086/432648
Sutcliffe JS, 1997, GENOME RES, V7, P368
Tamada K, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0015126
TANI Y, 1994, NEUROSCI LETT, V181, P169, DOI 10.1016/0304-3940(94)90586-X
van Woerden GM, 2007, NAT NEUROSCI, V10, P280, DOI 10.1038/nn1845
Veenstra-VanderWeele J, 2012, P NATL ACAD SCI USA, V109, P5469, DOI 10.1073/pnas.1112345109
Williams C A, 1995, Curr Probl Pediatr, V25, P216, DOI 10.1016/S0045-9380(06)80036-8
Williams CA, 2005, BRAIN DEV-JPN, V27, P88, DOI 10.1016/j.braindev.2003.09.014
Yashiro K, 2009, NAT NEUROSCI, V12, P777, DOI 10.1038/nn.2327
NR 55
TC 5
Z9 5
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD AUG 16
PY 2012
VL 7
IS 8
AR e43030
DI 10.1371/journal.pone.0043030
PG 9
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 993AN
UT WOS:000307824300025
PM 22916201
ER
PT J
AU Miu, AC
Pana, SE
Avram, J
AF Miu, Andrei C.
Pana, Simona E.
Avram, Julia
TI Emotional face processing in neurotypicals with autistic traits:
Implications for the broad autism phenotype
SO PSYCHIATRY RESEARCH
LA English
DT Article
DE Autistic traits; Fear conditioning; Attentional biases; Face processing;
Broad autism phenotype; Amygdala theory of autism
ID SPECTRUM QUOTIENT AQ; ASPERGER-SYNDROME; GENERAL-POPULATION; FUNCTIONING
AUTISM; AMYGDALA THEORY; FAMILY-HISTORY; EYE GAZE; FEAR; DISORDERS;
CHILDREN
AB The present study investigated emotional face processing in neurotypicals selected for autistic traits (AT). Participants (N = 81), who obtained scores one standard deviation above or below average on the Autism Spectrum Quotient, were tested using observational fear conditioning (FC), a face version of the attention probe task, and the "Reading the Mind in the Eyes" test. The results indicated that high AT participants displayed enhanced observational FC, no attentional bias to fearful faces, and increased latency (but normal accuracy) to recognizing the mental state of another. To a certain extent, this pattern resembles the social-emotional phenotype that was previously described in autism spectrum disorders. Therefore, these results may contribute to the broad autism phenotype perspective. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
C1 [Miu, Andrei C.; Pana, Simona E.; Avram, Julia] Univ Babes Bolyai, Cognit Neurosci Lab, Dept Psychol, Cluj Napoca 400015, CJ, Romania.
RP Miu, AC (reprint author), 37 Republicii St, Cluj Napoca 400015, CJ, Romania.
EM andreimiu@psychology.ro
RI Miu, Andrei/C-5184-2011
FU National University Research Council of Romania (CNCSIS) [411/2010];
Undergraduate Research Fellowship from Babes-Bolyai University
FX This research was supported by grant 411/2010 from the National
University Research Council of Romania (CNCSIS) to Andrei C. Miu, and an
Undergraduate Research Fellowship from Babes-Bolyai University to Simona
E. Pana.
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
Ashwin C, 2007, NEUROPSYCHOLOGIA, V45, P2, DOI 10.1016/j.neuropsychologia.2006.04.014
Ashwin C, 2006, PSYCHOL MED, V36, P835, DOI 10.1017/S0033291706007203
Austin EJ, 2005, PERS INDIV DIFFER, V38, P451, DOI 10.1016/j.paid.2004.04.022
Bailey A, 1998, J AUTISM DEV DISORD, V28, P369, DOI 10.1023/A:1026048320785
Baron-Cohen S, 2001, J AUTISM DEV DISORD, V31, P5, DOI 10.1023/A:1005653411471
Baron-Cohen S, 2000, NEUROSCI BIOBEHAV R, V24, P355, DOI 10.1016/S0149-7634(00)00011-7
BaronCohen S, 1997, J COGNITIVE NEUROSCI, V9, P548, DOI 10.1162/jocn.1997.9.4.548
Baron-Cohen S, 2002, TRENDS COGN SCI, V6, P248, DOI 10.1016/S1364-6613(02)01904-6
Baron-Cohen S, 2001, J CHILD PSYCHOL PSYC, V42, P241, DOI 10.1017/S0021963001006643
Baron-Cohen S, 1999, EUR J NEUROSCI, V11, P1891, DOI 10.1046/j.1460-9568.1999.00621.x
Bernier R, 2005, J AUTISM DEV DISORD, V35, P575, DOI 10.1007/s10803-005-0002-0
BOLTON P, 1994, J CHILD PSYCHOL PSYC, V35, P877, DOI 10.1111/j.1469-7610.1994.tb02300.x
Chakrabarti B, 2009, AUTISM RES, V2, P157, DOI 10.1002/aur.80
Constantino JN, 2005, BIOL PSYCHIAT, V57, P655, DOI 10.1016/j.biopsych.2004.12.014
Constantino JN, 2004, J CHILD PSYCHOL PSYC, V45, P719, DOI 10.1111/j.1469-7610.2004.00266.x
Constantino JN, 2003, ARCH GEN PSYCHIAT, V60, P524, DOI 10.1001/archpsyc.60.5.524
Constantino JN, 2005, SOCIAL RESPONSIVENES
Crisan LG, 2009, SOC COGN AFFECT NEUR, V4, P399, DOI 10.1093/scan/nsp019
Deeley Q, 2007, BIOL PSYCHIAT, V62, P207, DOI 10.1016/j.biopsych.2006.09.037
EKMAN P, 1976, ENVIRON PSYCH NONVER, V1, P56, DOI 10.1007/BF01115465
Elsabbagh M, 2009, BIOL PSYCHIAT, V65, P31, DOI 10.1016/j.biopsych.2008.09.034
Fusar-Poli P, 2009, J PSYCHIATR NEUROSCI, V34, P418
Gaigg SB, 2007, NEUROPSYCHOLOGIA, V45, P2125, DOI 10.1016/j.neuropsychologia.2007.01.012
Gerull FC, 2002, BEHAV RES THER, V40, P279, DOI 10.1016/S0005-7967(01)00013-4
Geschwind DH, 2007, CURR OPIN NEUROBIOL, V17, P103, DOI 10.1016/j.conb.2007.01.009
Gliga T, 2009, INFANCY, V14, P550, DOI 10.1080/15250000903144199
Grinter EJ, 2009, J AUTISM DEV DISORD, V39, P670, DOI 10.1007/s10803-008-0658-3
Happe F, 2006, J AUTISM DEV DISORD, V36, P5, DOI 10.1007/s10803-005-0039-0
Hermans EJ, 2009, BIOL PSYCHOL, V80, P348, DOI 10.1016/j.biopsycho.2008.12.002
Ho A, 2005, J AUTISM DEV DISORD, V35, P129, DOI 10.1007/s10803-004-1040-8
Hoekstra RA, 2007, ARCH PEDIAT ADOL MED, V161, P372, DOI 10.1001/archpedi.161.4.372
Hughes C, 1997, PSYCHOL MED, V27, P209, DOI 10.1017/S0033291796004308
Maestro S, 2002, J AM ACAD CHILD PSY, V41, P1239, DOI 10.1097/01.CHI.0000020277.43550.02
Manning JT, 2001, DEV MED CHILD NEUROL, V43, P160, DOI 10.1017/S0012162201000317
Manning JT, 1998, HUM REPROD, V13, P3000, DOI 10.1093/humrep/13.11.3000
Markram K, 2008, NEUROPSYCHOPHARMACOL, V33, P901, DOI 10.1038/sj.npp.1301453
Mathews A, 2005, ANNU REV CLIN PSYCHO, V1, P167, DOI 10.1146/annurev.clinpsy.1.102803.143916
Mathews A, 2003, VIS COGN, V10, P823, DOI 10.1080/13506280344000095
Olsson A, 2007, SOC COGN AFFECT NEUR, V2, P3, DOI 10.1093/scan/nsm005
Olsson A, 2004, PSYCHOL SCI, V15, P822, DOI 10.1111/j.0956-7976.2004.00762.x
Olsson A, 2007, NAT NEUROSCI, V10, P1095, DOI 10.1038/nn1968
Piven J, 1999, AM J PSYCHIAT, V156, P557
Piven J, 1997, AM J PSYCHIAT, V154, P185
Ronald A, 2006, J AM ACAD CHILD PSY, V45, P1206, DOI 10.1097/01.chi.0000230165.54117.41
Scheeren AM, 2008, J AUTISM DEV DISORD, V38, P276, DOI 10.1007/s10803-007-0389-x
Schultz RT, 2005, INT J DEV NEUROSCI, V23, P125, DOI 10.1016/j.ijdevneu.2004.12.012
Skuse DH, 2005, BRIT J PSYCHIAT, V187, P568, DOI 10.1192/bjp.187.6.568
Spiker D, 2002, AM J MED GENET, V114, P129, DOI 10.1002/ajmg.10188
Stewart ME, 2008, COGNITION, V109, P157, DOI 10.1016/j.cognition.2008.07.010
Stewart ME, 2009, AUTISM, V13, P133, DOI 10.1177/1362361308098515
Szatmari P, 2008, J AUTISM DEV DISORD, V38, P1859, DOI 10.1007/s10803-008-0576-4
Uono S, 2009, BRAIN COGNITION, V71, P229, DOI 10.1016/j.bandc.2009.08.015
Walter E, 2009, J AUTISM DEV DISORD, V39, P339, DOI 10.1007/s10803-008-0630-2
Wheelwright S, 2006, BRAIN RES, V1079, P47, DOI 10.1016/j.brainres.2006.01.012
NR 55
TC 0
Z9 0
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
IRELAND
SN 0165-1781
J9 PSYCHIAT RES
JI Psychiatry Res.
PD AUG 15
PY 2012
VL 198
IS 3
BP 489
EP 494
DI 10.1016/j.psychres.2012.01.024
PG 6
WC Psychiatry
SC Psychiatry
GA 050HQ
UT WOS:000312044800025
PM 22425467
ER
PT J
AU Villanueva, R
AF Villanueva, Rosa
TI The cerebellum and neuropsychiatric disorders
SO PSYCHIATRY RESEARCH
LA English
DT Review
DE Cognitive affective syndrome; Schizophrenia; Premenstrual dysphoric
disorder; Attention deficit/hyperactivity disorder; Major depression
ID ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; AMINO-ACID OXIDASE;
PURKINJE-CELL LOSS; PROTEIN EXPRESSION; BIPOLAR DISORDER; ESSENTIAL
TREMOR; WHITE-MATTER; SCHIZOPHRENIA; BRAIN; AUTISM
AB Relative to non-human primates, in humans the cerebellum, and prefrontal cortex are brain regions which have undergone major evolutionary changes. In recent decades, progress in molecular biology and advances in the development of functional neuroimaging analysis have shown that the evolution of the human cerebellum was accompanied by the acquisition of more functions than were previously deduced from human postmortem studies and animal experimentation. These new cerebellar functions included the control of attention and other cognitive functions, emotions and mood, and social behavior, which were all thought to represent cortical functions. The importance of this new view of cerebellar physiology has been confirmed by the frequency of neuropsychiatric disorders in individuals with cerebellar abnormalities. The information collected in this review emphasizes the importance of cerebellar studies in establishing the physiological substrate of mental diseases. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
C1 Hosp Univ La Paz, Serv Psiquiatria, Madrid 28046, Spain.
RP Villanueva, R (reprint author), Hosp Univ La Paz, Serv Psiquiatria, Paseo de la Castellana 261, Madrid 28046, Spain.
EM rosvp@telefonica.net
CR Alalade E, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0020035
Andreasen NC, 2008, BIOL PSYCHIAT, V64, P81, DOI 10.1016/j.biopsych.2008.01.003
Andreasen NC, 1998, SCHIZOPHRENIA BULL, V24, P203
Bailey A, 1998, BRAIN, V121, P889, DOI 10.1093/brain/121.5.889
Baillieux H, 2008, CLIN NEUROL NEUROSUR, V110, P763, DOI 10.1016/j.clineuro.2008.05.013
Baldacara L, 2011, J AFFECT DISORDERS, V135, P305, DOI 10.1016/j.jad.2011.06.059
Bauman ML, 2003, NOVART FDN SYMP, V251, P112
Bledsoe JC, 2011, J AM ACAD CHILD PSY, V50, P593, DOI 10.1016/j.jaac.2011.02.014
Boghi A, 2011, PSYCHIAT RES-NEUROIM, V192, P154, DOI 10.1016/j.pscychresns.2010.12.008
Brown P, 2011, CONSCIOUS COGN, V20, P1055, DOI 10.1016/j.concog.2010.12.003
Buchsbaum MS, 2007, AM J PSYCHIAT, V164, P1072, DOI 10.1176/appi.ajp.164.7.1072
Burnet PWJ, 2008, MOL PSYCHIATR, V13, P658, DOI 10.1038/mp.2008.47
Chaki S, 2011, CURR PHARM DESIGN, V17, P94
Chen J., 2010, MOL NEURODEGENER, V20, P60
Cohen M, 2011, INT J NEUROPSYCHOPH, V4, P1
Corti C, 2011, SCHIZOPHR RES, V128, P7, DOI 10.1016/j.schres.2011.01.021
Cousijn J, 2012, NEUROIMAGE, V59, P3845, DOI 10.1016/j.neuroimage.2011.09.046
CRUTCHFIELD JS, 1994, J NEUROSURG, V81, P115, DOI 10.3171/jns.1994.81.1.0115
Curatolo P, 2010, ITAL J PEDIATR, V36, DOI 10.1186/1824-7288-36-79
de la Fuente-Sandoval C, 2011, NEUROPSYCHOPHARMACOL, V36, P1781, DOI 10.1038/npp.2011.65
Demirtas-Tatlidede A, 2010, SCHIZOPHR RES, V124, P91, DOI 10.1016/j.schres.2010.08.015
Dempster EL, 2006, BMC MED GENET, V7, DOI 10.1186/1471-2350-7-10
Dervaux A., ADDICTION B IN PRESS, DOI 10.1111-j
Dickson PE, 2010, NEUROBIOL LEARN MEM, V94, P220, DOI 10.1016/j.nlm.2010.05.010
Eastwood SL, 2003, MOL PSYCHIATR, V8, P148, DOI 10.1038/sj.mp.4001233
Eastwood SL, 2001, NEUROSCIENCE, V105, P219, DOI 10.1016/S0306-4522(01)00141-5
Exner C, 2004, NEUROLOGY, V63, P2132
Fatemi SH, 2008, SCHIZOPHR RES, V99, P56, DOI 10.1016/j.schres.2007.11.018
Fitzgerald PB, 2008, HUM BRAIN MAPP, V29, P683, DOI 10.1002/hbm.20426
Forsyth JK, 2012, SCHIZOPHRENIA BULL, V38, P751, DOI 10.1093/schbul/sbq148
Fuentes CT, 2007, CEREBELLUM, V6, P232, DOI 10.1080/14734220701329268
Gillig Paulette Marie, 2010, Psychiatry (Edgmont), V7, P38
Gooch CM, 2010, NEUROPSYCHOLOGIA, V48, P1022, DOI 10.1016/j.neuropsychologia.2009.11.028
Greenstein D, 2011, PSYCHIAT RES-NEUROIM, V193, P131, DOI 10.1016/j.pscychresns.2011.02.010
GUZZETTA F, 1993, BRAIN DEV-JPN, V15, P439, DOI 10.1016/0387-7604(93)90084-L
Habas C, 2009, J NEUROSCI, V29, P8586, DOI 10.1523/JNEUROSCI.1868-09.2009
Habel U, 2005, NEUROIMAGE, V26, P206, DOI 10.1016/j.neuroimage.2005.01.014
Aso K, 2010, J COGNITIVE NEUROSCI, V22, P2913, DOI 10.1162/jocn.2010.21429
Harrison PJ, 2005, MOL PSYCHIATR, V10, P40, DOI 10.1038/sj.mp.4001558
HEH CWC, 1989, AM J PSYCHIAT, V146, P242
Heuser M, 2011, PSYCHIAT RES-NEUROIM, V192, P69, DOI 10.1016/j.pscychresns.2010.11.009
Hill SY, 2011, PSYCHIAT RES-NEUROIM, V194, P304, DOI 10.1016/j.pscychresns.2011.05.006
Ichimiya T, 2001, BIOL PSYCHIAT, V49, P20, DOI 10.1016/S0006-3223(00)01081-7
Ito M, 2008, NAT REV NEUROSCI, V9, P304, DOI 10.1038/nrn2332
Ito M, 2009, NEUROSCIENCE, V162, P666, DOI 10.1016/j.neuroscience.2009.01.019
Ivry R B, 1989, J Cogn Neurosci, V1, P136, DOI 10.1162/jocn.1989.1.2.136
Kalmbach BE, 2011, J NEUROSCI, V31, P2025, DOI 10.1523/JNEUROSCI.4212-10.2011
Kanaan RAA, 2009, BIOL PSYCHIAT, V66, P1067, DOI 10.1016/j.biopsych.2009.07.028
Katsetos CD, 1997, BIOL PSYCHIAT, V42, P213, DOI 10.1016/S0006-3223(96)00313-7
Kibby MY, 2008, J CHILD NEUROL, V23, P368, DOI 10.1177/08883073807309235
Koch G, 2010, FUNCT NEUROL, V25, P159
Konarski JZ, 2005, J PSYCHIATR NEUROSCI, V30, P178
Kyriakopoulos M, 2009, CURR OPIN PSYCHIATR, V22, P168, DOI 10.1097/YCO.0b013e328325aa23
Lee KH, 2009, PSYCHIAT RES, V166, P174, DOI 10.1016/j.psychres.2008.03.004
Liu H, 2011, J MAGN RESON IMAGING, V34, P1430, DOI 10.1002/jmri.22784
Louis ED, 2011, CEREBELLUM, V10, P812, DOI 10.1007/s12311-011-0291-0
Marien P, 2010, CEREBELLUM, V9, P405, DOI 10.1007/s12311-010-0177-6
Martin LA, 2010, EUR J NEUROSCI, V31, P544, DOI 10.1111/j.1460-9568.2009.07073.x
MARTIN P, 1995, SCHIZOPHRENIA BULL, V21, P241
MATHEW RJ, 1985, AM J PSYCHIAT, V142, P970
Mittleman G, 2008, SYNAPSE, V62, P544, DOI 10.1002/syn.20525
Mukaetova-Ladinska EB, 2002, NEUROSCI LETT, V317, P161, DOI 10.1016/S0304-3940(01)02458-2
O'Halloran CJ, 2012, J CLIN EXP NEUROPSYC, V34, P35, DOI 10.1080/13803395.2011.614599
Okugawa G, 2002, SCHIZOPHR RES, V55, P61, DOI 10.1016/S0920-9964(01)00248-1
OLNEY JW, 1995, ARCH GEN PSYCHIAT, V52, P998
Olney JW, 1999, J PSYCHIAT RES, V33, P523, DOI 10.1016/S0022-3956(99)00029-1
Palmen SJMC, 2004, BRAIN, V127, P2572, DOI 10.1093/brain/awh287
Passamonti L, 2011, BRAIN, V134, P2274, DOI 10.1093/brain/awr164
Pastura G, 2011, ARQ NEURO-PSIQUIAT, V69, P242, DOI 10.1590/S0004-282X2011000200020
Perlov E, 2010, J PSYCHIATR RES, V44, P938, DOI 10.1016/j.jpsychires.2010.02.016
Rapkin AJ, 2011, BIOL PSYCHIAT, V69, P374, DOI 10.1016/j.biopsych.2010.09.029
Riva D, 2000, BRAIN, V123, P1051, DOI 10.1093/brain/123.5.1051
Rogers TD, 2011, SYNAPSE, V65, P1204, DOI 10.1002/syn.20960
Schmahmann JD, 1998, BRAIN, V121, P561, DOI 10.1093/brain/121.4.561
SCHMAHMANN JD, 1991, ARCH NEUROL-CHICAGO, V48, P1178
Schmahmann JD, 2000, J NEUROLINGUIST, V13, P189, DOI 10.1016/S0911-6044(00)00011-7
Schmitt A, 2010, EUR ARCH PSY CLIN N, V260, P101, DOI 10.1007/s00406-009-0017-1
Schmitt A, 2011, EUR ARCH PSY CLIN N, V261, P150, DOI 10.1007/s00406-011-0242-2
Schmitt A, 2011, WORLD J BIOL PSYCHIA, V12, P99, DOI 10.3109/15622975.2011.598379
Siffert J, 2000, J NEURO-ONCOL, V48, P75, DOI 10.1023/A:1006483531811
Silk TJ, 2009, HUM BRAIN MAPP, V30, P2757, DOI 10.1002/hbm.20703
Smith SS, 1998, NATURE, V392, P926, DOI 10.1038/31948
SNIDER SR, 1982, NEUROSCI BIOBEHAV R, V6, P47, DOI 10.1016/0149-7634(82)90006-9
Solowij N., 2011, PSYCHOL MED, V5, P1
Soontornniyomkij B, 2011, J AFFECT DISORDERS, V133, P646, DOI 10.1016/j.jad.2011.04.044
Spottiswoode BS, 2011, ALCOHOL CLIN EXP RES, V35, P2174, DOI 10.1111/j.1530-0277.2011.01566.x
Steil B.M., 2003, P NATL ACAD SCI USA, V100, P14439
Stevens J.R., 1982, SCHIZOPHRENIA BRAIN, P112
Stoodley CJ, 2010, CORTEX, V46, P831, DOI 10.1016/j.cortex.2009.11.008
Strick PL, 2009, ANNU REV NEUROSCI, V32, P413, DOI 10.1146/annurev.neuro.31.060407.125606
Vaidya Chandan J, 2012, Curr Top Behav Neurosci, V9, P49, DOI 10.1007/7854_2011_138
VANDONGEN HR, 1994, NEUROLOGY, V44, P2040
Verrall L, 2007, EUR J NEUROSCI, V26, P1657, DOI 10.1111/j.1460-9568.2007.05769.x
Wei HG, 2011, J NEUROINFLAMM, V8, DOI 10.1186/1742-2094-8-52
WEINBERGER DR, 1980, AM J PSYCHIAT, V137, P359
Whitney ER, 2008, CEREBELLUM, V7, P406, DOI 10.1007/s12311-008-0043-y
Wisoff J H, 1984, Neurosurgery, V15, P707
Yeganeh-Doost P, 2011, CLINICS, V66, P71, DOI 10.1590/S1807-59322011001300009
Yin Y, 2011, NEUROSCI LETT, V498, P185, DOI 10.1016/j.neulet.2011.02.069
Yuan K, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0020708
Zwicker JG, 2009, J CHILD NEUROL, V24, P1273, DOI 10.1177/0883073809333537
NR 101
TC 17
Z9 17
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
IRELAND
SN 0165-1781
J9 PSYCHIAT RES
JI Psychiatry Res.
PD AUG 15
PY 2012
VL 198
IS 3
BP 527
EP 532
DI 10.1016/j.psychres.2012.02.023
PG 6
WC Psychiatry
SC Psychiatry
GA 050HQ
UT WOS:000312044800031
PM 22436353
ER
PT J
AU Weston, MC
Chen, HM
Swann, JW
AF Weston, Matthew C.
Chen, Hongmei
Swann, John W.
TI Multiple Roles for Mammalian Target of Rapamycin Signaling in Both
Glutamatergic and GABAergic Synaptic Transmission
SO JOURNAL OF NEUROSCIENCE
LA English
DT Article
ID LHERMITTE-DUCLOS-DISEASE; TEMPORAL-LOBE EPILEPSY; LIS1 MUTANT MICE;
NEUROTRANSMITTER RELEASE; MOUSE MODEL; HIPPOCAMPAL-NEURONS; TUBEROUS
SCLEROSIS; GRANULE CELLS; SOMA SIZE; PTEN
AB The mammalian target of rapamycin (mTOR) signaling pathway in neurons integrates a variety of extracellular signals to produce appropriate translational responses. mTOR signaling is hyperactive in neurological syndromes in both humans and mouse models that are characterized by epilepsy, autism, and cognitive disturbances. In addition, rapamycin, a clinically important immunosuppressant, is a specific and potent inhibitor of mTOR signaling. While mTOR is known to regulate growth and synaptic plasticity of glutamatergic neurons, its effects on basic parameters of synaptic transmission are less well studied, and its role in regulating GABAergic transmission is unexplored. We therefore performed an electrophysiological and morphological comparison of glutamatergic and GABAergic neurons in which mTOR signaling was either increased by loss of the repressor Pten or decreased by treatment with rapamycin. We found that hyperactive mTOR signaling increased evoked synaptic responses in both glutamatergic and GABAergic neurons by similar to 50%, due to an increase in the number of synaptic vesicles available for release, the number of synapses formed, and the miniature event size. Prolonged (72 h) rapamycin treatment prevented these abnormalities and also decreased synaptic transmission in wild-type glutamatergic, but not GABAergic, neurons. Further analyses suggested that hyperactivation of the mTOR pathway also impairs presynaptic function, possibly by interfering with vesicle fusion. Despite this presynaptic impairment, the net effect of Pten loss is enhanced synaptic transmission in both GABAergic and glutamatergic neurons, which has numerous implications, depending on where in the brain mutations of an mTOR suppressor gene occur.
C1 [Weston, Matthew C.; Chen, Hongmei; Swann, John W.] Jan & Dan Duncan Neurol Res Inst, Cain Fdn Labs, Houston, TX 77030 USA.
[Weston, Matthew C.; Chen, Hongmei; Swann, John W.] Baylor Coll Med, Dept Neurosci, Houston, TX 77030 USA.
[Weston, Matthew C.; Chen, Hongmei; Swann, John W.] Baylor Coll Med, Dept Pediat, Houston, TX 77030 USA.
RP Swann, JW (reprint author), Jan & Dan Duncan Neurol Res Inst, Cain Fdn Labs, 1250 Moursund St,Suite 1225, Houston, TX 77030 USA.
EM jswann@bcm.edu
FU NIH-NINDS Training Grant [T32 NS043124]; [NS018309]; [NS062992];
[P30HD024064]
FX This work was supported by an NIH-NINDS Training Grant T32 NS043124
(M.C.W.) and Grants NS018309, NS062992, and P30HD024064. We thank Dr.
Ralf Nehring for the cre-RFP lentivirus, and Drs. Mingshan Xue and
Christian Rosenmund for critical reading of this manuscript.
CR Akerman CJ, 2007, TRENDS NEUROSCI, V30, P382, DOI 10.1016/j.tins.2007.06.002
Backman SA, 2001, NAT GENET, V29, P396, DOI 10.1038/ng782
Bateup HS, 2011, J NEUROSCI, V31, P8862, DOI 10.1523/JNEUROSCI.1617-11.2011
BEKKERS JM, 1991, P NATL ACAD SCI USA, V88, P7834, DOI 10.1073/pnas.88.17.7834
BENARI Y, 1989, J PHYSIOL-LONDON, V416, P303
Buckmaster PS, 2011, EPILEPSIA, V52, P2057, DOI 10.1111/j.1528-1167.2011.03253.x
Cohen I, 2002, SCIENCE, V298, P1418, DOI 10.1126/science.1076510
Costa-Mattioli M, 2009, NEURON, V61, P10, DOI 10.1016/j.neuron.2008.10.055
DELCASTILLO J, 1954, J PHYSIOL-LONDON, V124, P560
Fraser MM, 2008, NEUROSCIENCE, V151, P476, DOI 10.1016/j.neuroscience.2007.10.048
Fu C, 2012, CEREB CORTEX, V22, P2111, DOI 10.1093/cercor/bhr300
Greenwood JSF, 2009, ANN NEUROL, V66, P644, DOI 10.1002/ana.21775
Habets RLP, 2005, J PHYSIOL-LONDON, V564, P173, DOI 10.1113/jphysiol.2004.079160
HEITMAN J, 1991, SCIENCE, V253, P905, DOI 10.1126/science.1715094
Hoeffer CA, 2010, TRENDS NEUROSCI, V33, P67, DOI 10.1016/j.tins.2009.11.003
Jaworski J, 2005, J NEUROSCI, V25, P11300, DOI 10.1523/JNEUROSCI.2270-05.2005
Jones DL, 2007, J NEUROPHYSIOL, V98, P2737, DOI 10.1152/jn.00938.2007
Jurado S, 2010, EMBO J, V29, P2827, DOI 10.1038/emboj.2010.160
Khalilov I, 2005, NEURON, V48, P787, DOI 10.1016/j.neuron.2005.09.026
Kwon CH, 2006, NEURON, V50, P377, DOI 10.1016/j.neuron.2006.03.023
Kwon CH, 2001, NAT GENET, V29, P404, DOI 10.1038/ng781
Ljungberg MC, 2009, DIS MODEL MECH, V2, P389, DOI 10.1242/dmm.002386
Lois C, 2002, SCIENCE, V295, P868, DOI 10.1126/science.1067081
Luikart BW, 2011, J NEUROSCI, V31, P4345, DOI 10.1523/JNEUROSCI.0061-11.2011
Meikle L, 2007, J NEUROSCI, V27, P5546, DOI 10.1523/JNEUROSCI.5540-06.2007
Moult PR, 2010, J NEUROSCI, V30, P4088, DOI 10.1523/JNEUROSCI.3614-09.2010
MUELLER AL, 1984, J NEUROSCI, V4, P860
Murthy VN, 2001, NEURON, V32, P673, DOI 10.1016/S0896-6273(01)00500-1
Orlova KA, 2010, J CLIN INVEST, V120, P1591, DOI 10.1172/JCI41592
Reim K, 2001, CELL, V104, P71, DOI 10.1016/S0092-8674(01)00192-1
Rosenmund C, 1996, NEURON, V16, P1197, DOI 10.1016/S0896-6273(00)80146-4
Rost BR, 2010, EUR J NEUROSCI, V32, P939, DOI 10.1111/j.1460-9568.2010.07387.x
Sarbassov DD, 2006, MOL CELL, V22, P159, DOI 10.1016/j.molcel.2006.03.029
Stevens CF, 2003, NEURON, V40, P381, DOI 10.1016/S0896-6273(03)00643-3
Tabuchi K, 2007, SCIENCE, V318, P71, DOI 10.1126/science.1146221
Tavazoie SF, 2005, NAT NEUROSCI, V8, P1727, DOI 10.1038/nn1566
Tyler WJ, 2001, J NEUROSCI, V21, P4249
van Spronsen M, 2010, CURR NEUROL NEUROSCI, V10, P207, DOI 10.1007/s11910-010-0104-8
Waites CL, 2011, TRENDS NEUROSCI, V34, P326, DOI 10.1016/j.tins.2011.03.004
Wang YL, 2007, ANN NEUROL, V61, P139, DOI 10.1002/ana.21058
Wang YL, 2006, NEUROSCI LETT, V401, P35, DOI 10.1016/j.neulet.2006.03.011
Xiong QJ, 2012, J NEUROSCI, V32, P1643, DOI 10.1523/JNEUROSCI.4480-11.2012
Xue MS, 2008, P NATL ACAD SCI USA, V105, P7875, DOI [10.1073/pnas.0803012105, 10.1072/pnas.0803012105]
Zhou J, 2009, J NEUROSCI, V29, P1773, DOI 10.1523/JNEUROSCI.5685-08.2009
Zoghbi HY, 2003, SCIENCE, V302, P826, DOI 10.1126/science.1089071
NR 45
TC 19
Z9 19
PU SOC NEUROSCIENCE
PI WASHINGTON
PA 11 DUPONT CIRCLE, NW, STE 500, WASHINGTON, DC 20036 USA
SN 0270-6474
J9 J NEUROSCI
JI J. Neurosci.
PD AUG 15
PY 2012
VL 32
IS 33
BP 11441
EP 11452
DI 10.1523/JNEUROSCI.1283-12.2012
PG 12
WC Neurosciences
SC Neurosciences & Neurology
GA 994OJ
UT WOS:000307940000026
PM 22895726
ER
PT J
AU Kosaka, H
Munesue, T
Ishitobi, M
Asano, M
Omori, M
Sato, M
Tomoda, A
Wada, Y
AF Kosaka, Hirotaka
Munesue, Toshio
Ishitobi, Makoto
Asano, Mizuki
Omori, Masao
Sato, Makoto
Tomoda, Akemi
Wada, Yuji
TI Long-term oxytocin administration improves social behaviors in a girl
with autistic disorder
SO BMC PSYCHIATRY
LA English
DT Article
DE Autism spectrum disorders (ASDs); Oxytocin; Social impairments
ID RECEPTOR; DEFICITS; HUMANS
AB Background: Patients with autism spectrum disorders (ASDs) exhibit core autistic symptoms including social impairments from early childhood and mostly show secondary disabilities such as irritability and aggressive behavior based on core symptoms. However, there are still no radical treatments of social impairments in these patients. Oxytocin has been reported to play important roles in multiple social behaviors dependent on social recognition, and has been expected as one of the effective treatments of social impairments of patients with ASDs.
Case presentation: We present a case of a 16-year-old girl with autistic disorder who treated by long-term administration of oxytocin nasal spray. Her autistic symptoms were successfully treated by two month administration; the girl's social interactions and social communication began to improve without adverse effects. Her irritability and aggressive behavior also improved dramatically with marked decreases in aberrant behavior checklist scores from 69 to 7.
Conclusion: This case is the first to illustrate long-term administration of oxytocin nasal spray in the targeted treatment of social impairments in a female with autistic disorder. This case suggests that long-term nasal oxytocin spray is promising and well-tolerated for treatment of social impairments of patients with ASDs.
C1 [Kosaka, Hirotaka; Sato, Makoto; Tomoda, Akemi; Wada, Yuji] Univ Fukui, Res Ctr Child Mental Dev, Fukui 9101193, Japan.
[Kosaka, Hirotaka; Ishitobi, Makoto; Asano, Mizuki; Wada, Yuji] Univ Fukui, Dept Neuropsychiat, Fac Med Sci, Fukui 9101193, Japan.
[Munesue, Toshio] Kanazawa Univ, Res Ctr Child Mental Dev, Kanazawa, Ishikawa 9208641, Japan.
[Omori, Masao] Fukui Prefectural Univ, Fac Nursing & Social Welf Sci, Fukui 9101195, Japan.
[Sato, Makoto] Univ Fukui, Fac Med Sci, Div Cell Biol & Neurosci, Dept Morphol & Physiol Sci, Fukui 9101193, Japan.
RP Kosaka, H (reprint author), Univ Fukui, Res Ctr Child Mental Dev, Fukui 9101193, Japan.
EM hirotaka@u-fukui.ac.jp
FU Japan Society for the Promotion of Science [21791120]; Japan Research
Foundation For Clinical Pharmacology; SENSHIN Medical Research
Foundation
FX This case report was funded in part by Grants-in-Aid for Scientific
Research from the Japan Society for the Promotion of Science (21791120)
and by the Kobayashi-Magobei Kinen Fund, Japan Research Foundation For
Clinical Pharmacology and SENSHIN Medical Research Foundation. Part of
this case report is the result of "Integrated research on
neuropsychiatric disorders" carried out under the Strategic Research
Program for Brain Sciences by the MEXT of Japan.
CR AMAN MG, 1985, AM J MENT DEF, V89, P485
Andari E, 2010, P NATL ACAD SCI USA, V107, P4389, DOI 10.1073/pnas.0910249107
Baron-Cohen S, 2000, NEUROSCI BIOBEHAV R, V24, P355, DOI 10.1016/S0149-7634(00)00011-7
Domes G, 2007, BIOL PSYCHIAT, V61, P731, DOI 10.1016/j.biopsych.2006.07.015
Domes G, 2007, BIOL PSYCHIAT, V62, P1187, DOI 10.1016/j.biopsych.2007.03.025
Guastella AJ, 2010, BIOL PSYCHIAT, V67, P692, DOI 10.1016/j.biopsych.2009.09.020
Inoue H, 2010, BIOL PSYCHIAT, V68, P1066, DOI 10.1016/j.biopsych.2010.07.019
Kimura T, 1996, ENDOCRINOLOGY, V137, P780, DOI 10.1210/en.137.2.780
Kosfeld M, 2005, NATURE, V435, P673, DOI 10.1038/nature03701
Kuehn BM, 2011, JAMA-J AM MED ASSOC, V305, P659, DOI 10.1001/jama.2011.117
Modahl C, 1998, BIOL PSYCHIAT, V43, P270, DOI 10.1016/S0006-3223(97)00439-3
Munesue T, 2010, NEUROSCI RES, V67, P181, DOI 10.1016/j.neures.2010.03.004
Rosenfeld AJ, 2011, SCHIZOPHRENIA BULL, V37, P1077, DOI 10.1093/schbul/sbq015
Takayanagi Y, 2005, P NATL ACAD SCI USA, V102, P16096, DOI 10.1073/pnas.0505312102
Wing L, 2002, J CHILD PSYCHOL PSYC, V43, P307, DOI 10.1111/1469-7610.00023
NR 15
TC 16
Z9 16
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1471-244X
J9 BMC PSYCHIATRY
JI BMC Psychiatry
PD AUG 13
PY 2012
VL 12
AR 110
DI 10.1186/1471-244X-12-110
PG 4
WC Psychiatry
SC Psychiatry
GA 019BI
UT WOS:000309711500001
PM 22888794
ER
PT J
AU Sato, W
Toichi, M
Uono, S
Kochiyama, T
AF Sato, Wataru
Toichi, Motomi
Uono, Shota
Kochiyama, Takanori
TI Impaired social brain network for processing dynamic facial expressions
in autism spectrum disorders
SO BMC NEUROSCIENCE
LA English
DT Article
DE Amygdala; Autism spectrum disorders (ASD); Dynamic facial expression;
Fusiform gyrus; Inferior frontal gyrus; Medial prefrontal cortex; Middle
temporal gyrus/superior temporal sulcus; Mirror neuron system
ID HIGH-FUNCTIONING AUTISM; VOXEL-BASED MORPHOMETRY; MIRROR NEURON SYSTEM;
MEDIAL TEMPORAL-LOBE; ASPERGER-SYNDROME; BIOLOGICAL MOTION; ATYPICAL
DEVELOPMENT; FACE PERCEPTION; CORTICAL ACTIVATION; PREFRONTAL CORTEX
AB Background: Impairment of social interaction via facial expressions represents a core clinical feature of autism spectrum disorders (ASD). However, the neural correlates of this dysfunction remain unidentified. Because this dysfunction is manifested in real-life situations, we hypothesized that the observation of dynamic, compared with static, facial expressions would reveal abnormal brain functioning in individuals with ASD. We presented dynamic and static facial expressions of fear and happiness to individuals with high-functioning ASD and to age- and sex-matched typically developing controls and recorded their brain activities using functional magnetic resonance imaging (fMRI).
Result: Regional analysis revealed reduced activation of several brain regions in the ASD group compared with controls in response to dynamic versus static facial expressions, including the middle temporal gyrus (MTG), fusiform gyrus, amygdala, medial prefrontal cortex, and inferior frontal gyrus (IFG). Dynamic causal modeling analyses revealed that bi-directional effective connectivity involving the primary visual cortex-MTG-IFG circuit was enhanced in response to dynamic as compared with static facial expressions in the control group. Group comparisons revealed that all these modulatory effects were weaker in the ASD group than in the control group.
Conclusions: These results suggest that weak activity and connectivity of the social brain network underlie the impairment in social interaction involving dynamic facial expressions in individuals with ASD.
C1 [Sato, Wataru; Kochiyama, Takanori] Kyoto Univ, Primate Res Inst, Hakubi Project, Inuyama, Aichi 4848506, Japan.
[Sato, Wataru; Toichi, Motomi] Org Promoting Dev Disorder Res, Sakyo Ku, Kyoto 6068392, Japan.
[Toichi, Motomi; Uono, Shota] Kyoto Univ, Grad Sch Med, Fac Human Hlth Sci, Sakyo Ku, Kyoto 6068507, Japan.
RP Sato, W (reprint author), Kyoto Univ, Primate Res Inst, Hakubi Project, Inuyama, Aichi 4848506, Japan.
EM sato@pri.kyoto-u.ac.jp
FU Benesse Corporation; JSPS; JSPS Funding Program for Next Generation
World-Leading Researchers; Organization for Promoting Developmental
Disorder Research
FX We thank Professor S. Yoshikawa for her helpful advice and ATR Brain
Activity Imaging Center for their supports of acquiring fMRI data. This
study was supported by funds from the Benesse Corporation, JSPS
Grants-in-Aid for Scientific Research, JSPS Funding Program for Next
Generation World-Leading Researchers, and the Organization for Promoting
Developmental Disorder Research.
CR Adolphs R, 2003, NAT REV NEUROSCI, V4, P165, DOI 10.1038/nrn1056
Allison T, 2000, TRENDS COGN SCI, V4, P267, DOI 10.1016/S1364-6613(00)01501-1
American Psychiatric Association, 2000, DIAGN STAT MAN MENT
Ashburner J, 1999, HUM BRAIN MAPP, V7, P254, DOI 10.1002/(SICI)1097-0193(1999)7:4<254::AID-HBM4>3.0.CO;2-G
Ashwin C, 2007, NEUROPSYCHOLOGIA, V45, P2, DOI 10.1016/j.neuropsychologia.2006.04.014
Atkinson AP, 2009, NEUROPSYCHOLOGIA, V47, P3023, DOI 10.1016/j.neuropsychologia.2009.05.019
Bachevalier J, 1996, J AUTISM DEV DISORD, V26, P217, DOI 10.1007/BF02172015
BARONCOHEN S, 1985, COGNITION, V21, P37, DOI 10.1016/0010-0277(85)90022-8
Baron-Cohen S, 1999, EUR J NEUROSCI, V11, P1891, DOI 10.1046/j.1460-9568.1999.00621.x
Barton RA, 2000, AMYGDALA FUNCTIONAL, P479
Behrmann M, 2006, TRENDS COGN SCI, V10, P258, DOI 10.1016/j.tics.2006.05.001
Belmonte MK, 2004, J NEUROSCI, V24, P9228, DOI 10.1523/JNEUROSCI.3340-04.2004
Bird G, 2006, NEUROIMAGE, V31, P1614, DOI 10.1016/j.neuroimage.2006.02.037
Blake R, 2003, PSYCHOL SCI, V14, P151, DOI 10.1111/1467-9280.01434
Blakemore SJ, 2008, NAT REV NEUROSCI, V9, P267, DOI 10.1038/nrn2353
Boddaert N, 2004, NEUROIMAGE, V23, P364, DOI 10.1016/j.neuroimage.2004.06.016
Brock J, 2002, DEV PSYCHOPATHOL, V14, P209
Brothers L., 1990, CONCEPTS NEUROSCIENC, V1, P27
Buccino G, 2001, EUR J NEUROSCI, V13, P400, DOI 10.1046/j.1460-9568.2001.01385.x
Buccino G, 2004, J COGNITIVE NEUROSCI, V16, P114, DOI 10.1162/089892904322755601
Calder AJ, 2001, NAT REV NEUROSCI, V2, P352, DOI 10.1038/35072584
Castelli F, 2002, BRAIN, V125, P1839, DOI 10.1093/brain/awf189
Catani M, 2002, NEUROIMAGE, V17, P77, DOI 10.1006/nimg.2002.1136
Corona R, 1998, CHILD DEV, V69, P1494
Critchley HD, 2000, BRAIN, V123, P2203, DOI 10.1093/brain/123.11.2203
Dakin S, 2005, NEURON, V48, P497, DOI 10.1016/j.neuron.2005.10.018
Dalton KM, 2005, NAT NEUROSCI, V8, P519, DOI 10.1038/nn1421
Dapretto M, 2006, NAT NEUROSCI, V9, P28, DOI 10.1038/nn1611
Darwin C, 1872, EXPRESSION EMOTIONS
DEACON TW, 1992, BRAIN RES, V573, P8, DOI 10.1016/0006-8993(92)90109-M
Deeley Q, 2007, BIOL PSYCHIAT, V62, P207, DOI 10.1016/j.biopsych.2006.09.037
Dejerine JJ, 1895, ANATOMIE CTR NERVEUX
Thiebaut de Schotten M, 2011, NEUROIMAGE, V54, P49, DOI 10.1016/j.neuroimage.2010.07.055
Eickhoff SB, 2005, NEUROIMAGE, V25, P1325, DOI 10.1016/j.neuroimage.2004.12.034
Ekman P., 1976, PICTURES FACIAL AFFE
Ekman P, 1975, UNMASKING FACE GUIDE
Emery NJ, 2000, UNDERSTANDING OTHER, P274
Emery NJ, 2001, BEHAV NEUROSCI, V115, P515, DOI 10.1037//0735-7044.115.3.515
Freitag CM, 2008, NEUROPSYCHOLOGIA, V46, P1480, DOI 10.1016/j.neuropsychologia.2007.12.025
FRISTON KJ, 1991, J CEREBR BLOOD F MET, V11, P690
Friston KJ, 1995, HUM BRAIN MAPP, V3, P165, DOI 10.1002/hbm.460030303
Friston KJ, 2002, NEUROIMAGE, V16, P484, DOI 10.1006/nimg.2002.1091
Friston KJ, 2003, NEUROIMAGE, V19, P1273, DOI 10.1016/S1053-8119(03)00202-7
FRISTON KJ, 1995, NEUROIMAGE, V2, P45, DOI 10.1006/nimg.1995.1007
Frith U, 2003, PHILOS T R SOC B, V358, P459, DOI 10.1098/rstb.2002.1218
Frith CD, 2007, PHILOS T R SOC B, V362, P671, DOI 10.1098/rstb.2006.2003
Gallagher HL, 2000, NEUROPSYCHOLOGIA, V38, P11, DOI 10.1016/S0028-3932(99)00053-6
Gallese V, 2004, TRENDS COGN SCI, V8, P396, DOI 10.1016/j.tics.2004.07.002
Hadjikhani N, 2007, HUM BRAIN MAPP, V28, P441, DOI 10.1002/hbm.20283
Hadjikhani N, 2004, NEUROIMAGE, V22, P1141, DOI 10.1016/j.neuroimage.2004.03.025
Hadjikhani N, 2006, CEREB CORTEX, V16, P1276, DOI 10.1093/cercor/bh069
Hall GBC, 2003, AM J PSYCHIAT, V160, P1439, DOI 10.1176/appi.ajp.160.8.1439
Hamilton AFDC, 2008, Q J EXP PSYCHOL, V61, P101, DOI 10.1080/17470210701508798
Happe F, 1996, NEUROREPORT, V8, P197, DOI 10.1097/00001756-199612200-00040
Haxby JV, 2000, TRENDS COGN SCI, V4, P223, DOI 10.1016/S1364-6613(00)01482-0
Hazlett EA, 2004, NEUROPSYCHOBIOLOGY, V49, P115, DOI 10.1159/000076719
Herrington JD, 2007, RES AUTISM SPECT DIS, V1, P14, DOI 10.1016/j.rasd.2006.07.002
Hietanen JK, 2003, J EXP PSYCHOL HUMAN, V29, P1228, DOI 10.1037/0096-1523.29.6.1228
Hobson R. Peter, 1993, AUTISM DEV MIND
Hobson RP, 1999, J CHILD PSYCHOL PSYC, V40, P649, DOI 10.1111/1469-7610.00481
Hoffman EA, 2000, NAT NEUROSCI, V3, P80, DOI 10.1038/71152
Holmes A.P., 1998, NEUROIMAGE 2, V7, P754
Hubert B, 2007, J AUTISM DEV DISORD, V37, P1386, DOI 10.1007/s10803-006-0275-y
Hubl D, 2003, NEUROLOGY, V61, P1232
Hyde KL, 2010, HUM BRAIN MAPP, V31, P556, DOI 10.1002/hbm.20887
Iacoboni M, 2006, NAT REV NEUROSCI, V7, P942, DOI 10.1038/nrn2024
Iacoboni M, 2005, CURR OPIN NEUROBIOL, V15, P632, DOI 10.1016/j.conb.2005.10.010
Johnson MH, 2005, DEV PSYCHOPATHOL, V17, P599, DOI 10.1017/S0954579405050297
Just MA, 2007, CEREB CORTEX, V17, P951, DOI 10.1093/cercor/bhl006
Just MA, 2004, BRAIN, V127, P1811, DOI 10.1093/brain/awh199
Kaiser MD, 2010, AUTISM RES, V3, P191, DOI 10.1002/aur.137
Kana RK, 2011, NEUROSCI BIOBEHAV R, V35, P894, DOI 10.1016/j.neubiorev.2010.10.007
Kilts CD, 2003, NEUROIMAGE, V18, P156, DOI 10.1006/nimg.2002.1323
Kleinhans NM, 2008, BRAIN, V131, P1000, DOI 10.1093/brain/awm334
Kosaka H, 2010, NEUROIMAGE, V50, P1357, DOI 10.1016/j.neuroimage.2010.01.085
Koshino H, 2008, CEREB CORTEX, V18, P289, DOI 10.1093/cercor/bhm054
Koshino H, 2005, NEUROIMAGE, V24, P810, DOI 10.1016/j.neuroimage.2004.09.028
Koyama T, 2007, PSYCHIAT CLIN NEUROS, V61, P99, DOI 10.1111/j.1440-1819.2007.01617.x
Kwon H, 2004, DEV MED CHILD NEUROL, V46, P760, DOI 10.1017/S0012162204001306
LaBar KS, 2003, CEREB CORTEX, V13, P1023, DOI 10.1093/cercor/13.10.1023
Lancaster JL, 2000, HUM BRAIN MAPP, V10, P120, DOI 10.1002/1097-0193(200007)10:3<120::AID-HBM30>3.0.CO;2-8
Lee Thomas E. Jr., 2006, Mammalian Species, P1
Leslie KR, 2004, NEUROIMAGE, V21, P601, DOI 10.1016/j.neuroimage.2003.09.038
Levitt JG, 2003, CEREB CORTEX, V13, P728, DOI 10.1093/cercor/13.7.728
Liu L, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0013492
Ludwig E, 1956, ATLAS CEREBRI HUMANI
McIntosh DN, 2006, DEVELOPMENTAL SCI, V9, P295, DOI 10.1111/j.1467-7687.2006.00492.x
Moore DG, 1997, BRIT J DEV PSYCHOL, V15, P401
Mukaida S, 2000, FOOLPROOF UTIL UNPUB
Nacewicz BM, 2006, ARCH GEN PSYCHIAT, V63, P1417, DOI 10.1001/archpsyc.63.12.1417
Niedenthal PM, 2001, COGNITION EMOTION, V15, P853
Nishitani N, 2004, ANN NEUROL, V55, P558, DOI 10.1002/ana.20031
Oberman LM, 2009, DEVELOPMENTAL SCI, V12, P510, DOI 10.1111/j.1467-7687.2008.00796.x
Ogai Masahiro, 2003, Neuroreport, V14, P559, DOI 10.1097/00001756-200303240-00006
OLDFIELD RC, 1971, NEUROPSYCHOLOGIA, V9, P97, DOI 10.1016/0028-3932(71)90067-4
Pelphrey KA, 2008, DEV PSYCHOPATHOL, V20, P1081, DOI 10.1017/S0954579408000515
Pelphrey KA, 2007, SOC COGN AFFECT NEUR, V2, P140, DOI 10.1093/scan/nsm010
Penny WD, 2010, PLOS COMPUT BIOL, V6, DOI 10.1371/journal.pcbi.1000709
Petrides M, 2002, EUR J NEUROSCI, V16, P291, DOI 10.1046/j.1460-9568.2001.02090.x
Phillips ML, 1997, NATURE, V389, P495, DOI 10.1038/39051
Pierce K, 2001, BRAIN, V124, P2059, DOI 10.1093/brain/124.10.2059
Pierce K, 2004, BRAIN, V127, P2703, DOI 10.1093/brain/awh289
Piggot J, 2004, J AM ACAD CHILD PSY, V43, P473, DOI 10.1097/01.chi.0000111363.94169.37
Puce A, 1998, J NEUROSCI, V18, P2188
Ramachandran VS, 2006, SCI AM, V295, P62
Rilling JK, 2008, NAT NEUROSCI, V11, P426, DOI 10.1038/nn2072
Rizzolatti G, 2001, NAT REV NEUROSCI, V2, P661, DOI 10.1038/35090060
Sato W, 2010, BRAIN RES, V1315, P92, DOI 10.1016/j.brainres.2009.12.003
Sato W, 2004, COGNITIVE BRAIN RES, V20, P81, DOI 10.1016/j.cogbrainres.2004.01.008
Sato W, 2007, COGNITION, V104, P1, DOI 10.1016/j.cognition.2006.05.001
Sato W, 2007, J NONVERBAL BEHAV, V31, P119, DOI 10.1007/s10919-007-0025-7
Sato W, 2004, COGNITION EMOTION, V18, P701, DOI 10.1080/02699930341000176
Schopler E., 1986, CHILDHOOD AUTISM RAT
Schultz J, 2009, EXP BRAIN RES, V194, P465, DOI 10.1007/s00221-009-1721-9
Schultz RT, 2000, ARCH GEN PSYCHIAT, V57, P331, DOI 10.1001/archpsyc.57.4.331
Schumann CM, 2006, J NEUROSCI, V26, P7674, DOI 10.1523/JNEUROSCI.1285-06.2006
Seghier ML, 2011, CEREB CORTEX, V21, P1519, DOI 10.1093/cercor/bhq203
SIGMAN MD, 1992, CHILD DEV, V63, P796, DOI 10.1111/j.1467-8624.1992.tb01662.x
Sokal R. R., 1995, BIOMETRY PRINCIPLES, V3rd
Stephan KE, 2010, NEUROIMAGE, V49, P3099, DOI 10.1016/j.neuroimage.2009.11.015
Stephan KE, 2009, NEUROIMAGE, V46, P1004, DOI 10.1016/j.neuroimage.2009.03.025
Tardif C, 2007, J AUTISM DEV DISORD, V37, P1469, DOI 10.1007/s10803-006-0223-x
Tomasello M, 2005, BEHAV BRAIN SCI, V28, P675, DOI 10.1017/S0140525X05000129
Tong F, 1998, NEURON, V21, P753, DOI 10.1016/S0896-6273(00)80592-9
TOOBY J, 1990, ETHOL SOCIOBIOL, V11, P375, DOI 10.1016/0162-3095(90)90017-Z
Trautmann SA, 2009, BRAIN RES, V1284, P100, DOI 10.1016/j.brainres.2009.05.075
Uono S, 2009, BRAIN COGNITION, V71, P229, DOI 10.1016/j.bandc.2009.08.015
Uono S, 2011, SOC NEUROSCI-UK, V6, P452, DOI 10.1080/17470919.2011.605593
van der Gaag C, 2007, SOC NEUROSCI, V2, P179, DOI 10.1080/17470910701376878
van der Gaag C, 2007, SOC COGN AFFECT NEUR, V2, P93, DOI 10.1093/scan/nsm002
van Kooten IAJ, 2008, BRAIN, V131, P987, DOI 10.1093/brain/awn033
Villalobos ME, 2005, NEUROIMAGE, V25, P916, DOI 10.1016/j.neuroimage.2004.12.022
VINTER A, 1986, CHILD DEV, V57, P66, DOI 10.2307/1130638
Wang AT, 2004, J AM ACAD CHILD PSY, V43, P481, DOI 10.1097/01.chi.0000111481.76722.66
Wang AT, 2007, ARCH GEN PSYCHIAT, V64, P698, DOI 10.1001/archpsyc.64.6.698
Welchew DE, 2005, BIOL PSYCHIAT, V57, P991, DOI 10.1016/j.biopsych.2005.01.028
Wheaton KJ, 2004, NEUROIMAGE, V22, P277, DOI 10.1016/j.neuroimage.2003.12.043
Wicker B, 2008, SOC COGN AFFECT NEUR, V3, P135, DOI 10.1093/scan/nsn007
Wicker B, 2003, NEURON, V40, P655, DOI 10.1016/S0896-6273(03)00679-2
Williams JHG, 2001, NEUROSCI BIOBEHAV R, V25, P287, DOI 10.1016/S0149-7634(01)00014-8
WORSLEY KJ, 1995, NEUROIMAGE, V2, P173, DOI 10.1006/nimg.1995.1023
Worsley KJ, 1996, HUM BRAIN MAPP, V4, P58, DOI 10.1002/(SICI)1097-0193(1996)4:1<58::AID-HBM4>3.0.CO;2-O
YIRMIYA N, 1989, J CHILD PSYCHOL PSYC, V30, P725, DOI 10.1111/j.1469-7610.1989.tb00785.x
Yoshikawa S, 2008, COGN AFFECT BEHAV NE, V8, P25, DOI 10.3758/CABN.8.1.25
NR 144
TC 15
Z9 15
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1471-2202
J9 BMC NEUROSCI
JI BMC Neurosci.
PD AUG 13
PY 2012
VL 13
AR 99
DI 10.1186/1471-2202-13-99
PG 17
WC Neurosciences
SC Neurosciences & Neurology
GA 014TA
UT WOS:000309397400001
PM 22889284
ER
PT J
AU Heinzen, EL
Depondt, C
Cavalleri, GL
Ruzzo, EK
Walley, NM
Need, AC
Ge, DL
He, M
Cirulli, ET
Zhao, Q
Cronin, KD
Gumbs, CE
Campbell, CR
Hong, LK
Maia, JM
Shianna, KV
McCormack, M
Radtke, RA
O'Conner, GD
Mikati, MA
Gallentine, WB
Husain, AM
Sinha, SR
Chinthapalli, K
Puranam, RS
McNamara, JO
Ottman, R
Sisodiya, SM
Delanty, N
Goldstein, DB
AF Heinzen, Erin L.
Depondt, Chantal
Cavalleri, Gianpiero L.
Ruzzo, Elizabeth K.
Walley, Nicole M.
Need, Anna C.
Ge, Dongliang
He, Min
Cirulli, Elizabeth T.
Zhao, Qian
Cronin, Kenneth D.
Gumbs, Curtis E.
Campbell, C. Ryan
Hong, Linda K.
Maia, Jessica M.
Shianna, Kevin V.
McCormack, Mark
Radtke, Rodney A.
O'Conner, Gerard D.
Mikati, Mohamad A.
Gallentine, William B.
Husain, Aatif M.
Sinha, Saurabh R.
Chinthapalli, Krishna
Puranam, Ram S.
McNamara, James O.
Ottman, Ruth
Sisodiya, Sanjay M.
Delanty, Norman
Goldstein, David B.
TI Exome Sequencing Followed by Large-Scale Genotyping Fails to Identify
Single Rare Variants of Large Effect in Idiopathic Generalized Epilepsy
SO AMERICAN JOURNAL OF HUMAN GENETICS
LA English
DT Article
ID GENOME-WIDE ASSOCIATION; RECURRENT MICRODELETIONS; 16P13.11 PREDISPOSE;
SPECTRUM; AUTISM; GENES; RISK
AB Idiopathic generalized epilepsy (ICE) is a complex disease with high heritability, but little is known about its genetic architecture. Rare copy-number variants have been found to explain nearly 3% of individuals with IGE; however, it remains unclear whether variants with moderate effect size and frequencies below what are reliably detected with genome-wide association studies contribute significantly to disease risk. In this study, we compare the exome sequences of 118 individuals with IGE and 242 controls of European ancestry by using next-generation sequencing. The exome-sequenced epilepsy cases include study subjects with two forms of IGE, including juvenile myoclonic epilepsy (n = 93) and absence epilepsy (n = 25). However, our discovery strategy did not assume common genetic control between the subtypes of IGE considered. In the sequence data, as expected, no variants were significantly associated with the IGE phenotype or more specific IGE diagnoses. We then selected 3,897 candidate epilepsy-susceptibility variants from the sequence data and genotyped them in a larger set of 878 individuals with IGE and 1,830 controls. Again, no variant achieved statistical significance. However, 1,935 variants were observed exclusively in cases either as heterozygous or homozygous genotypes. It is likely that this set of variants includes real risk factors. The lack of significant association evidence of single variants with disease in this two-stage approach emphasizes the high genetic heterogeneity of epilepsy disorders, suggests that the impact of any individual single-nucleotide variant in this disease is small, and indicates that gene-based approaches might be more successful for future sequencing studies of epilepsy predisposition.
C1 [Heinzen, Erin L.; Ruzzo, Elizabeth K.; Walley, Nicole M.; Need, Anna C.; Ge, Dongliang; He, Min; Cirulli, Elizabeth T.; Zhao, Qian; Cronin, Kenneth D.; Gumbs, Curtis E.; Campbell, C. Ryan; Hong, Linda K.; Maia, Jessica M.; Shianna, Kevin V.; Goldstein, David B.] Duke Univ, Sch Med, Ctr Human Genome Variat, Durham, NC 27708 USA.
[Heinzen, Erin L.; Need, Anna C.; Ge, Dongliang; Shianna, Kevin V.] Duke Univ, Sch Med, Dept Med, Med Genet Sect, Durham, NC 27708 USA.
[Depondt, Chantal] Univ Libre Brussels, Hop Erasme, Dept Neurol, B-1070 Brussels, Belgium.
[Cavalleri, Gianpiero L.; McCormack, Mark; Delanty, Norman] Royal Coll Surgeons Ireland, Dublin 2, Ireland.
[Radtke, Rodney A.; Husain, Aatif M.; Sinha, Saurabh R.] Duke Univ, Sch Med, Div Neurol, Dept Med, Durham, NC 27710 USA.
[O'Conner, Gerard D.; Delanty, Norman] Beaumont Hosp, Div Neurol, Dublin 9, Ireland.
[Mikati, Mohamad A.; Gallentine, William B.] Duke Univ, Sch Med, Dept Pediat, Div Pediat Neurol, Durham, NC 27710 USA.
[Chinthapalli, Krishna; Sisodiya, Sanjay M.] UCL, Inst Neurol, Dept Clin & Expt Epilepsy, London WC1N 3BG, England.
[Puranam, Ram S.; McNamara, James O.] Duke Univ, Dept Neurobiol, Durham, NC 27710 USA.
[Ottman, Ruth] Columbia Univ, Sergievsky Ctr, New York, NY 10032 USA.
[Ottman, Ruth] Columbia Univ, Dept Neurol, New York, NY 10032 USA.
[Ottman, Ruth] Columbia Univ, Dept Epidemiol, New York, NY 10032 USA.
[Ottman, Ruth] New York State Psychiat Inst & Hosp, Div Epidemiol, New York, NY 10032 USA.
[Goldstein, David B.] Duke Univ, Dept Mol Genet & Microbiol, Durham, NC 27708 USA.
RP Heinzen, EL (reprint author), Duke Univ, Sch Med, Ctr Human Genome Variat, Durham, NC 27708 USA.
EM e.heinzen@duke.edu; d.goldstein@duke.edu
RI Cavalleri, Gianpiero/A-6632-2010; Ottman, Ruth/O-2371-2013
FU National Institute of Neurological Disorders and Stroke [RC2NS070344];
National Institute of Mental Health [RC2MH089915]; National Institute of
Allergy and Infectious Diseases [UO1AIO67854, 1RC2NS070342]; Ellison
Medical Foundation; National Institute on Aging [P30 AG028377]; Wellcome
Trust [084730]; National Institute for Health Research [08-08-SCC];
Fonds National de la Recherche Scientifique; Fondation Erasme;
Universite Libre de Bruxelles; Fondation Erasme, Universite Libre de
Bruxelles, Brainwave-The Irish Epilepsy Association/the Medical Research
Charities Group of Ireland/Health Research Board [2009/001]; Programme
for Human Genomics; Programme for Research in Third Level Institutions
(PRTLI3); Irish Higher Education Authority; Health Research Board of
Ireland's Translational Research Scholars award
FX We thank all the individuals who kindly participated, as well as the
physicians who recruited them. We also acknowledge all of the
collaborators and groups who contributed controls for ascertaining the
frequency of candidate variants in the population; these collaborators
include the Murdock Study Community Registry and Biorepository (R.
Murdock), D. Daskalakis, D. Attix, V. Dixon, O. Chiba-Falek, J. McEvoy,
V. Shashi, R. Brown, A. Holden, E. Behr, W. Lowe, P. Lugar, J. Milner,
K. Welsh-Bohmer, C. Hulette, J. Burke, D. Valle, J. Hoover-Fong, N.
Sobriera, D. Marchuk, S. Palmer, E. Pras, D. Lancet, and Z. Farfel. This
project was funded by the National Institute of Neurological Disorders
and Stroke (RC2NS070344), the National Institute of Mental Health
(RC2MH089915), the National Institute of Allergy and Infectious Diseases
(UO1AIO67854, 1RC2NS070342), the Ellison Medical Foundation (O.
Chiba-Falek), the National Institute on Aging (P30 AG028377), the
Wellcome Trust (084730), the National Institute for Health Research
(grant 08-08-SCC), the Fonds National de la Recherche Scientifique, the
Fondation Erasme, Universite Libre de Bruxelles, Brainwave-The Irish
Epilepsy Association/the Medical Research Charities Group of
Ireland/Health Research Board award 2009/001, and the Programme for
Human Genomics and the Programme for Research in Third Level
Institutions (PRTLI3) funded by the Irish Higher Education Authority.
M.M.C. was supported by a Health Research Board of Ireland's
Translational Research Scholars award.
CR Adzhubei IA, 2010, NAT METHODS, V7, P248, DOI 10.1038/nmeth0410-248
Aldinger KA, 2009, CLIN GENET, V75, P425, DOI 10.1111/j.1399-0004.2009.01186_2.x
Berkovic SF, 1998, ANN NEUROL, V43, P435, DOI 10.1002/ana.410430405
Commission on Classification and Terminology of the International League Against Epilepsy, 1989, EPILEPSIA, V30, P389
de Kovel CGF, 2010, BRAIN, V133, P23, DOI 10.1093/brain/awp262
Ge DL, 2011, BIOINFORMATICS, V27, P1998, DOI 10.1093/bioinformatics/btr317
Heinzen EL, 2010, AM J HUM GENET, V86, P707, DOI 10.1016/j.ajhg.2010.03.018
Helbig I, 2009, NAT GENET, V41, P160, DOI 10.1038/ng.292
Hemminki K, 2006, NEUROEPIDEMIOLOGY, V27, P67, DOI 10.1159/000094976
Klassen T, 2011, CELL, V145, P1036, DOI 10.1016/j.cell.2011.05.025
Li H, 2009, BIOINFORMATICS, V25, P2078, DOI 10.1093/bioinformatics/btp352
Li H, 2009, BIOINFORMATICS, V25, P1754, DOI 10.1093/bioinformatics/btp324
MacArthur DG, 2012, SCIENCE, V335, P823, DOI 10.1126/science.1215040
Mefford HC, 2010, GENOME MED, V2, DOI 10.1186/gm192
Mefford HC, 2010, PLOS GENET, V6, DOI 10.1371/journal.pgen.1000962
Michos O, 2004, DEVELOPMENT, V131, P3401, DOI 10.1242/dev.01251
Mishto M, 2011, BIOCHEM BIOPH RES CO, V408, P65, DOI 10.1016/j.bbrc.2011.03.117
Murata S, 2001, EMBO J, V20, P5898, DOI 10.1093/emboj/20.21.5898
Need A. G., 2012, AM J HUM GENET
Need Anna C, 2010, Dialogues Clin Neurosci, V12, P37
Need AC, 2009, PLOS GENET, V5, DOI 10.1371/journal.pgen.1000373
Pagnamenta AT, 2009, EUR J HUM GENET, V17, P687, DOI 10.1038/ejhg.2008.228
Price AL, 2010, AM J HUM GENET, V86, P832, DOI 10.1016/j.ajhg.2010.04.005
Price AL, 2006, NAT GENET, V38, P904, DOI 10.1038/ng1847
Purcell S, 2007, AM J HUM GENET, V81, P559, DOI 10.1086/519795
Sharp AJ, 2008, NAT GENET, V40, P322, DOI 10.1038/ng.93
Shindou H, 2009, J BIOL CHEM, V284, P1, DOI 10.1074/jbc.R800046200
Skol AD, 2006, NAT GENET, V38, P209, DOI 10.1038/ng1706
Stefansson H, 2008, NATURE, V455, P232, DOI 10.1038/nature07229
The Epi4K Consortium, 2012, EPILEPSIA, DOI doi.org/10.1111/j.1528-1167.2012.03511.x
Vacic V, 2011, NATURE, V471, P499, DOI 10.1038/nature09884
Vastrik I, 2007, GENOME BIOL, V8, DOI 10.1186/gb-2007-8-3-r39
Weiss LA, 2008, NEW ENGL J MED, V358, P667, DOI 10.1056/NEJMoa075974
NR 33
TC 30
Z9 32
PU CELL PRESS
PI CAMBRIDGE
PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA
SN 0002-9297
J9 AM J HUM GENET
JI Am. J. Hum. Genet.
PD AUG 10
PY 2012
VL 91
IS 2
BP 293
EP 302
DI 10.1016/j.ajhg.2012.06.016
PG 10
WC Genetics & Heredity
SC Genetics & Heredity
GA 990CN
UT WOS:000307608700007
PM 22863189
ER
PT J
AU Bozdagi, O
Sakurai, T
Dorr, N
Pilorge, M
Takahashi, N
Buxbaum, JD
AF Bozdagi, Ozlem
Sakurai, Takeshi
Dorr, Nathan
Pilorge, Marion
Takahashi, Nagahide
Buxbaum, Joseph D.
TI Haploinsufficiency of Cyfip1 Produces Fragile X-Like Phenotypes in Mice
SO PLOS ONE
LA English
DT Article
ID MENTAL-RETARDATION PROTEIN; LONG-TERM POTENTIATION;
PRADER-WILLI-SYNDROME; COPY NUMBER VARIATION; SYNAPTIC PLASTICITY; MOUSE
MODEL; SOCIAL APPROACH; CRITICAL REGION; 4 GENES; SCHIZOPHRENIA
AB Background: Copy number variation (CNV) at the 15q11.2 region, which includes a gene that codes for CYFIP1 (cytoplasmic FMR1 interacting protein 1), has been implicated in autism, intellectual disability and additional neuropsychiatric phenotypes. In the current study we studied the function of Cyfip1 in synaptic physiology and behavior, using mice with a disruption of the Cyfip1 gene.
Methodology/Principal Findings: We observed that in Cyfip1 heterozygous mice metabotropic glutamate receptor (mGluR)-dependent long-term depression (LTD) induced by paired-pulse low frequency stimulation (PP-LFS) was significantly increased in comparison to wildtype mice. In addition, mGluR-LTD was not affected in the presence of protein synthesis inhibitor in the Cyfip1 heterozygous mice, while the same treatment inhibited LTD in wildtype littermate controls. mGluR-agonist (RS)-3,5-dihydroxyphenylglycine (DHPG)-induced LTD was also significantly increased in hippocampal slices from Cyfip1 heterozygous mice and again showed independence from protein synthesis only in the heterozygous animals. Furthermore, we observed that the mammalian Target of Rapamycin (mTOR) inhibitor rapamycin was only effective at reducing mGluR-LTD in wildtype animals. Behaviorally, Cyfip1 heterozygous mice showed enhanced extinction of inhibitory avoidance. Application of both mGluR5 and mGluR1 antagonist to slices from Cyfip1 heterozygous mice reversed the increase in DHPG-induced LTD in these mice.
Conclusions/Significance: These results demonstrate that haploinsufficiency of Cyfip1 mimics key aspects of the phenotype of Fmr1 knockout mice and are consistent with the hypothesis that these effects are mediated by interaction of Cyfip1 and Fmrp in regulating activity-dependent translation. The data provide support for a model where CYFIP1 haploinsufficiency in patients results in intermediate phenotypes increasing risk for neuropsychiatric disorders.
C1 [Bozdagi, Ozlem; Sakurai, Takeshi; Dorr, Nathan; Pilorge, Marion; Takahashi, Nagahide; Buxbaum, Joseph D.] Mt Sinai Sch Med, Seaver Autism Ctr Res & Treatment, New York, NY 10029 USA.
[Bozdagi, Ozlem; Sakurai, Takeshi; Dorr, Nathan; Pilorge, Marion; Takahashi, Nagahide; Buxbaum, Joseph D.] Mt Sinai Sch Med, Dept Psychiat, New York, NY USA.
[Buxbaum, Joseph D.] Mt Sinai Sch Med, Dept Neurosci, New York, NY USA.
[Buxbaum, Joseph D.] Mt Sinai Sch Med, Dept Genet & Genom Sci, New York, NY USA.
RP Bozdagi, O (reprint author), Mt Sinai Sch Med, Seaver Autism Ctr Res & Treatment, New York, NY 10029 USA.
EM joseph.buxbaum@mssm.edu
FU Seaver Foundation
FX This work was supported by the Seaver Foundation. OB and TS are Seaver
Fellows. The funders had no role in study design, data collection and
analysis, decision to publish, or preparation of the manuscript.
CR Antar LN, 2004, J NEUROSCI, V24, P2648, DOI 10.1523/JNEUROSCI.0099-04.2004
Bittel DC, 2006, PEDIATRICS, V118, pE1276, DOI 10.1542/peds.2006.0424
Botzolakis EJ, 2011, MOL CELL NEUROSCI, V46, P122, DOI 10.1016/j.mcn.2010.08.012
Bozdagi O, 2010, J NEUROSCI, V30, P9984, DOI 10.1523/JNEUROSCI.1223-10.2010
Burnside R, 2011, HUM GENET, V130, P517, DOI 10.1007/s00439-011-0970-4
Butler MG, 2004, PEDIATRICS, V113, P565, DOI 10.1542/peds.113.3.565
Chai JH, 2003, AM J HUM GENET, V73, P898, DOI 10.1086/378816
Cooper GM, 2011, NAT GENET, V43, P838, DOI 10.1038/ng.909
Costa-Mattioli M, 2009, NEURON, V61, P10, DOI 10.1016/j.neuron.2008.10.055
Dolen G, 2007, NEURON, V56, P955, DOI 10.1016/j.neuron.2007.12.001
Doornbos M, 2009, EUR J MED GENET, V52, P108, DOI 10.1016/j.ejmg.2009.03.010
Elder GA, 2008, BEHAV BRAIN RES, V191, P256, DOI 10.1016/j.bbr.2008.03.036
Ferrari F, 2007, MOL CELL NEUROSCI, V34, P343, DOI 10.1016/j.mcn.2006.11.015
Garber KB, 2008, EUR J HUM GENET, V16, P666, DOI 10.1038/ejhg.2008.61
Godfraind JM, 1996, AM J MED GENET, V64, P246
Goosens KA, 2001, LEARN MEMORY, V8, P148, DOI 10.1101/lm.37601
Gross C, 2010, J NEUROSCI, V30, P10624, DOI 10.1523/JNEUROSCI.0402-10.2010
Heyser CJ, 2004, CURR PROTOC NEUROSCI, pChapter 8, DOI [10.1002/0471142301.ns0818s25, DOI 10.1002/0471142301.NS0818S25]
Horsthemke B, 2008, AM J MED GENET A, V146A, P2041, DOI 10.1002/ajmg.a.32364
Hou LF, 2006, NEURON, V51, P441, DOI 10.1016/j.neuron.2006.07.005
Huber KM, 2002, P NATL ACAD SCI USA, V99, P7746, DOI 10.1073/pnas.122205699
Izumi N, 2008, J BIOL CHEM, V283, P12981, DOI 10.1074/jbc.M710282200
James AP, 2006, BIOCHIM BIOPHYS ACTA, V1762, p[11, 986]
Kirov G, 2009, HUM MOL GENET, V18, P1497, DOI 10.1093/hmg/ddp043
Kirov G, 2010, EXPERT REV NEUROTHER, V10, P25, DOI [10.1586/ern.09.133, 10.1586/ERN.09.133]
Lauterborn JC, 2007, J NEUROSCI, V27, P10685, DOI 10.1523/JNEUROSCI.2624-07.2007
Leblond CS, 2012, PLOS GENET, V8, DOI 10.1371/journal.pgen.1002521
Moy SS, 2009, GENES BRAIN BEHAV, V8, P129, DOI 10.1111/j.1601-183X.2008.00452.x
Murphy SM, 2001, MOL BIOL CELL, V12, P3340
Murthy SK, 2007, CYTOGENET GENOME RES, V116, P135, DOI 10.1159/000097433
Nadler JJ, 2004, GENES BRAIN BEHAV, V3, P303, DOI 10.1111/j.1601-183X.2004.00071.x
Napoli I, 2008, CELL, V134, P1042, DOI 10.1016/j.cell.2008.07.031
Nosyreva ED, 2006, J NEUROPHYSIOL, V95, P3291, DOI 10.1152/jn.01316.2005
Paradee W, 1999, NEUROSCIENCE, V94, P185, DOI 10.1016/S0306-4522(99)00285-7
Peters SU, 2011, J CHILD PSYCHOL PSYC
PHILLIPS RG, 1992, BEHAV NEUROSCI, V106, P274, DOI 10.1037//0735-7044.106.2.274
Rogers DC, 1997, MAMM GENOME, V8, P711, DOI 10.1007/s003359900551
Sahoo T, 2006, J MED GENET, V43, P512, DOI 10.1136/jmg.2005.036913
Sakurai T, 2011, AUTISM RES, V4, P28, DOI 10.1002/aur.169
Schenck A, 2001, P NATL ACAD SCI USA, V98, P8844, DOI 10.1073/pnas.151231598
Schenck A, 2003, NEURON, V38, P887, DOI 10.1016/S0896-6273(03)00354-4
Shu WG, 2005, P NATL ACAD SCI USA, V102, P9643, DOI 10.1073/pnas.0503739102
Spencer CM, 2011, AUTISM RES, V4, P40, DOI 10.1002/aur.168
Stefansson H, 2008, NATURE, V455, P232, DOI 10.1038/nature07229
Tam GWC, 2010, BIOCHEM SOC T, V38, P445, DOI 10.1042/BST0380445
van der Zwaag B, 2010, AM J MED GENET B, V153B, P960, DOI 10.1002/ajmg.b.31055
von der Lippe C, 2011, EUR J MED GENET, V54, P357, DOI 10.1016/j.ejmg.2010.12.008
Weiler IJ, 2004, P NATL ACAD SCI USA, V101, P17504, DOI 10.1073/pnas.0407533101
NR 48
TC 16
Z9 16
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD AUG 10
PY 2012
VL 7
IS 8
AR e42422
DI 10.1371/journal.pone.0042422
PG 11
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 986XO
UT WOS:000307380900037
PM 22900020
ER
PT J
AU Napoli, E
Ross-Inta, C
Wong, S
Hung, C
Fujisawa, Y
Sakaguchi, D
Angelastro, J
Omanska-Klusek, A
Schoenfeld, R
Giulivi, C
AF Napoli, Eleonora
Ross-Inta, Catherine
Wong, Sarah
Hung, Connie
Fujisawa, Yasuko
Sakaguchi, Danielle
Angelastro, James
Omanska-Klusek, Alicja
Schoenfeld, Robert
Giulivi, Cecilia
TI Mitochondrial Dysfunction in Pten Haplo-Insufficient Mice with Social
Deficits and Repetitive Behavior: Interplay between Pten and p53
SO PLOS ONE
LA English
DT Article
ID C-OXIDASE DEFICIENCY; AUTISM SPECTRUM DISORDERS;
LHERMITTE-DUCLOS-DISEASE; RILEY-RUVALCABA-SYNDROME; TUMOR-SUPPRESSOR
GENE; FRAGILE-X-SYNDROME; COPY NUMBER; TRANSCRIPTION FACTOR; DNA-DAMAGE;
ALZHEIMERS-DISEASE
AB Etiology of aberrant social behavior consistently points to a strong polygenetic component involved in fundamental developmental pathways, with the potential of being enhanced by defects in bioenergetics. To this end, the occurrence of social deficits and mitochondrial outcomes were evaluated in conditional Pten (Phosphatase and tensin homolog) haplo-insufficient mice, in which only one allele was selectively knocked-out in neural tissues. Pten mutations have been linked to Alzheimer's disease and syndromic autism spectrum disorders, among others. By 4-6 weeks of age, Pten insufficiency resulted in the increase of several mitochondrial Complex activities (II-III, IV and V) not accompanied by increases in mitochondrial mass, consistent with an activation of the PI3K/Akt pathway, of which Pten is a negative modulator. At 8-13 weeks of age, Pten haplo-insufficient mice did not show significant behavioral abnormalities or changes in mitochondrial outcomes, but by 20-29 weeks, they displayed aberrant social behavior (social avoidance, failure to recognize familiar mouse, and repetitive self-grooming), macrocephaly, increased oxidative stress, decreased cytochrome c oxidase (CCO) activity (50%) and increased mtDNA deletions in cerebellum and hippocampus. Mitochondrial dysfunction was the result of a downregulation of p53-signaling pathway evaluated by lower protein expression of p21 (65% of controls) and the CCO chaperone SCO2 (47% of controls), two p53-downstream targets. This mechanism was confirmed in Pten-deficient striatal neurons and, HCT 116 cells with different p53 gene dosage. These results suggest a unique pathogenic mechanism of the Pten-p53 axis in mice with aberrant social behavior: loss of Pten (via p53) impairs mitochondrial function elicited by an early defective assembly of CCO and later enhanced by the accumulation of mtDNA deletions. Consistent with our results, (i) SCO2 deficiency and/or CCO activity defects have been reported in patients with learning disabilities including autism and (ii) mutated proteins in ASD have been found associated with p53-signaling pathways.
C1 [Napoli, Eleonora; Ross-Inta, Catherine; Wong, Sarah; Hung, Connie; Fujisawa, Yasuko; Sakaguchi, Danielle; Angelastro, James; Omanska-Klusek, Alicja; Schoenfeld, Robert; Giulivi, Cecilia] Univ Calif Davis, Dept Mol Biosci, Sch Vet Med, Davis, CA 95616 USA.
[Giulivi, Cecilia] Univ Calif Davis, Med Invest Neurodev Disorders Inst, Sch Med, Davis, CA 95616 USA.
RP Napoli, E (reprint author), Univ Calif Davis, Dept Mol Biosci, Sch Vet Med, Davis, CA 95616 USA.
EM cgiulivi@ucdavis.edu
FU Autism Speaks Foundation [58739]; MIND Institute; Elsa U. Pardee
Foundation; National Institute of Environmental Health Sciences [NIEHS
R01-ES012691, NIEHS R01-ES020392]
FX This work was supported by funds provided by Autism Speaks Foundation
(#58739); and, partially, by the MIND Institute, Elsa U. Pardee
Foundation and National Institute of Environmental Health Sciences
(NIEHS R01-ES012691 & NIEHS R01-ES020392). The funding agencies had no
role in study design, data collection and analysis, decision to publish,
or preparation of the manuscript.
CR Acin-Perez R, 2008, MOL CELL, V32, P529, DOI 10.1016/j.molcel.2008.10.021
Ali IU, 1999, J NATL CANCER I, V91, P1922, DOI 10.1093/jnci/91.22.1922
Amaral DG, 2008, TRENDS NEUROSCI, V31, P137, DOI 10.1016/j.tins.2007.12.005
ARMSTRONG JF, 1995, CURR BIOL, V5, P931, DOI 10.1016/S0960-9822(95)00183-7
Backman SA, 2001, NAT GENET, V29, P396, DOI 10.1038/ng782
Barrientos A, 1997, MOL BRAIN RES, V52, P284, DOI 10.1016/S0169-328X(97)00278-7
Belmonte MK, 2006, NAT NEUROSCI, V9, P1221, DOI 10.1038/nn1765
Butler MG, 2005, J MED GENET, V42, P318, DOI 10.1136/jmg.2004.024646
Buxbaum JD, 2007, AM J MED GENET B, V144B, P484, DOI 10.1002/ajmg.b.30493
Cantley LC, 1999, P NATL ACAD SCI USA, V96, P4240, DOI 10.1073/pnas.96.8.4240
Carper RA, 2000, BRAIN, V123, P836, DOI 10.1093/brain/123.4.836
Chang CJ, 2004, J BIOL CHEM, V279, P29841, DOI 10.1074/jbc.M401488200
Chao HT, 2010, NATURE, V468, P263, DOI 10.1038/nature09582
Chauhan A, 2011, J NEUROCHEM, V117, P209, DOI 10.1111/j.1471-4159.2011.07189.x
Chen ZB, 2005, NATURE, V436, P725, DOI 10.1038/nature03918
Chiu S, 2007, J DEV BEHAV PEDIATR, V28, P31, DOI 10.1097/01.DBP.0000257518.60083.2d
CHOMYN A, 1992, P NATL ACAD SCI USA, V89, P4221, DOI 10.1073/pnas.89.10.4221
Chow LML, 2006, CANCER LETT, V241, P184, DOI 10.1016/j.canlet.2005.11.042
Cinato E, 2001, GENESIS, V31, P118, DOI 10.1002/gene.10014
Clay HB, 2011, INT J DEV NEUROSCI, V29, P311, DOI 10.1016/j.ijdevneu.2010.08.007
Crawley J.N, 2000, WHATS WRONG MY MOUSE
Crawley JN, 1999, BRAIN RES, V835, P18, DOI 10.1016/S0006-8993(98)01258-X
Cusco I, 2009, HUM MOL GENET, V18, P1795, DOI 10.1093/hmg/ddp092
Delatycki MB, 2003, J MED GENET, V40, DOI 10.1136/jmg.40.8.e92
Diaz F, 2002, NUCLEIC ACIDS RES, V30, P4626, DOI 10.1093/nar/gkf602
Drage MG, 2002, J NEUROCYTOL, V31, P681, DOI 10.1023/A:1025747813463
Ekstrand MI, 2004, HUM MOL GENET, V13, P935, DOI 10.1093/hmg/ddh109
Elder LM, 2008, J AUTISM DEV DISORD, V38, P1104, DOI 10.1007/s10803-007-0495-9
Elson JL, 2001, AM J HUM GENET, V68, P802, DOI 10.1086/318801
Emamian ES, 2004, NAT GENET, V36, P131, DOI 10.1038/ng1296
Eng C, 2003, HUM MUTAT, V22, P183, DOI 10.1002/humu.10257
Ezugha H, 2010, J CHILD NEUROL, V25, P1232, DOI 10.1177/0883073809361165
Azevedo FAC, 2009, J COMP NEUROL, V513, P532, DOI 10.1002/cne.21974
Fombonne E, 1999, J AUTISM DEV DISORD, V29, P113, DOI 10.1023/A:1023036509476
Fraser MM, 2008, NEUROSCIENCE, V151, P476, DOI 10.1016/j.neuroscience.2007.10.048
Fraser MM, 2004, CANCER RES, V64, P7773, DOI 10.1158/0008-5472.CAN-04-2487
Freeman DJ, 2003, CANCER CELL, V3, P117, DOI 10.1016/S1535-6108(03)00021-7
Garcia-Cao I, 2012, CELL, V149, P49, DOI 10.1016/j.cell.2012.02.030
Gaveriaux-Ruff C, 2007, PHARMACOL THERAPEUT, V113, P619, DOI 10.1016/j.pharmthera.2006.12.003
Giulivi C, 2010, JAMA-J AM MED ASSOC, V304, P2389, DOI 10.1001/jama.2010.1706
Goffin A, 2001, AM J MED GENET, V105, P521, DOI 10.1002/ajmg.1477
Goghari VM, 2007, CEREB CORTEX, V17, P415, DOI 10.1093/cercor/bhj158
Griffin RJ, 2005, J NEUROCHEM, V93, P105, DOI 10.1111/j.1471-4159.2004.02949.x
Grossman SR, 1998, MOL CELL, V2, P405, DOI 10.1016/S1097-2765(00)80140-9
HALTIA M, 1992, BRAIN PATHOL, V2, P133, DOI 10.1111/j.1750-3639.1992.tb00681.x
Hardan AY, 2006, AM J PSYCHIAT, V163, P1290, DOI 10.1176/appi.ajp.163.7.1290
Hassel B, 1998, J NEUROCHEM, V71, P1511
Haukvik UK, 2009, J PSYCHIATR RES, V43, P1287, DOI 10.1016/j.jpsychires.2009.05.001
HAYASHI JI, 1991, P NATL ACAD SCI USA, V88, P10614, DOI 10.1073/pnas.88.23.10614
Haynes V, 2010, AM J PHYSIOL-ENDOC M, V298, pE978, DOI 10.1152/ajpendo.00739.2009
He GG, 2005, ONCOGENE, V24, P2929, DOI 10.1038/sj.onc.1208474
Herman GE, 2007, AM J MED GENET A, V143A, P589, DOI 10.1002/ajmg.a.31619
Hertz-Picciotto I, 2006, ENVIRON HEALTH PERSP, V114, P1119, DOI 10.1289/ehp.8483
Hertz-Picciotto I, 2009, EPIDEMIOLOGY, V20, P84, DOI 10.1097/EDE.0b013e3181902d15
Hirasawa M, 2001, NEUROSCI RES, V40, P125, DOI 10.1016/S0168-0102(01)00216-4
Howard R, 2000, AM J PSYCHIAT, V157, P172, DOI 10.1176/appi.ajp.157.2.172
Isaacs JS, 1997, CANCER RES, V57, P2986
Jaksch M, 2000, HUM MOL GENET, V9, P795, DOI 10.1093/hmg/9.5.795
Joost K, 2010, PEDIATR NEUROL, V42, P227, DOI 10.1016/j.pediatrneurol.2009.10.004
Kakiuchi C, 2005, INT J NEUROPSYCHOPH, V8, P515, DOI 10.1017/S1461145705005213
Kalkman HO, 2006, PHARMACOL THERAPEUT, V110, P117, DOI 10.1016/j.pharmthera.2005.10.014
Kaufman BA, 2007, MOL BIOL CELL, V18, P3225, DOI 10.1091/mbc.E07-05-0404
KEMPER TL, 1993, NEUROL CLIN, V11, P175
Kerr F, 2006, FEBS LETT, V580, P3121, DOI 10.1016/j.febslet.2006.04.064
Khoury Marie P, 2011, Genes Cancer, V2, P453, DOI 10.1177/1947601911408893
Kwon CH, 2006, NEURON, V50, P377, DOI 10.1016/j.neuron.2006.03.023
Larsson NG, 1998, NAT GENET, V18, P231, DOI 10.1038/3033
Lawrence YA, 2010, ACTA NEUROL SCAND, V121, P99, DOI 10.1111/j.1600-0404.2009.01234.x
Leary SC, 2009, HUM MOL GENET, V18, P2230, DOI 10.1093/hmg/ddp158
Lebedeva MA, 2009, BBA-BIOENERGETICS, V1787, P328, DOI 10.1016/j.bbabio.2009.01.004
Lee HC, 2000, BIOCHEM J, V348, P425, DOI 10.1042/0264-6021:3480425
Lesche R, 2002, GENESIS, V32, P148, DOI 10.1002/gene.10036
Li YT, 2011, BLOOD, V117, P6702, DOI 10.1182/blood-2010-09-309864
Mao JH, 2003, ONCOGENE, V22, P8379, DOI 10.1038/sj.onc.1207083
Matoba S, 2006, SCIENCE, V312, P1650, DOI 10.1126/science.1126863
Mayo LD, 2001, P NATL ACAD SCI USA, V98, P11598, DOI 10.1073/pnas.181181198
Mayo LD, 2002, J BIOL CHEM, V277, P5484, DOI 10.1074/jbc.M108302200
McKenzie PP, 1999, CLIN CANCER RES, V5, P4199
Meesters PD, 2012, AM J GERIAT PSYCHIAT, V20, P18, DOI 10.1097/JGP.0b013e3182011b7f
Merks JHM, 2003, J MED GENET, V40, DOI 10.1136/jmg.40.10.e111
Moretti A, 2003, MOL PSYCHIATR, V8, P773, DOI 10.1038/sj.mp.4001353
Moy SS, 2004, GENES BRAIN BEHAV, V3, P287, DOI 10.1111/j.1601-183X.2004.00076.x
Nadler JJ, 2004, GENES BRAIN BEHAV, V3, P303, DOI 10.1111/j.1601-183X.2004.00071.x
Napoli E, 2011, HUM MOL GENET, V20, P3079, DOI 10.1093/hmg/ddr211
Noack H, 2006, BBA-GEN SUBJECTS, V1760, P141, DOI 10.1016/j.bbagen.2005.12.007
O'Roak BJ, 2012, NATURE, DOI nature10989
O'Roak BJ, 2012, NAT GENET, V44, P471
Ozonoff S, 2008, AUTISM RES, V1, P320, DOI 10.1002/aur.53
Payne BAI, 2011, NAT GENET, V43, P806, DOI 10.1038/ng.863
Pessah IN, 2008, NEUROTOXICOLOGY, V29, P532, DOI 10.1016/j.neuro.2008.02.006
Prabakaran S, 2004, MOL PSYCHIATR, V9, P684, DOI 10.1038/sj.mp.4001511
Rickle A, 2006, J NEUROSCI RES, V84, P596, DOI 10.1002/jnr.20970
SAH VP, 1995, NAT GENET, V10, P175, DOI 10.1038/ng0695-175
Santoro L, 2000, NEUROMUSCULAR DISORD, V10, P450, DOI 10.1016/S0960-8966(99)00122-4
Sayan BS, 2006, J BIOL CHEM, V281, P13566, DOI 10.1074/jbc.M512467200
Sims NR, 2008, NAT PROTOC, V3, P1228, DOI 10.1038/nprot.2008.105
Stambolic V, 2001, MOL CELL, V8, P317, DOI 10.1016/S1097-2765(01)00323-9
St-Pierre J, 2006, CELL, V127, P397, DOI 10.1016/j.cell.2006.09.024
Sung HJ, 2010, NAT COMMUN, V1, DOI 10.1038/ncomms1003
SUOMALAINEN A, 1992, J CLIN INVEST, V90, P61, DOI 10.1172/JCI115856
Swerdlow RH, 1997, NEUROLOGY, V49, P918
Tang YY, 2000, MOL BIOL CELL, V11, P2349
TAYLOR RW, 1993, BIOCHIM BIOPHYS ACTA, V1181, P261, DOI 10.1016/0925-4439(93)90030-5
Terauchi A, 2010, NATURE, V465, P783, DOI 10.1038/nature09041
Torres M, 2004, INT J RADIAT ONCOL, V58, P479, DOI 10.1016/j.ijrobp.2003.09.062
Trettel F, 2000, HUM MOL GENET, V9, P2799, DOI 10.1093/hmg/9.19.2799
Tulinius M, 2003, NEUROPEDIATRICS, V34, P87
Varga EA, 2009, GENET MED, V11, P111, DOI 10.1097/GIM.0b013e31818fd762
Wanka C, 2011, ONCOGENE
Watcharasit P, 2002, P NATL ACAD SCI USA, V99, P7951, DOI 10.1073/pnas.122062299
Wolfe A, 2008, J NEUROENDOCRINOL, V20, P909, DOI 10.1111/j.1365-2826.2008.01746.x
Yang H, 2010, HUM MOL GENET, V19, P170, DOI 10.1093/hmg/ddp477
Ylikallio E, 2010, HUM MOL GENET, V19, P2695, DOI 10.1093/hmg/ddq163
YONEDA M, 1992, P NATL ACAD SCI USA, V89, P11164, DOI 10.1073/pnas.89.23.11164
Zhang XD, 2010, ACTA PHARMACOL SIN, V31, P1208, DOI 10.1038/aps.2010.151
Zhou BHP, 2001, NAT CELL BIOL, V3, P973, DOI 10.1038/ncb1101-973
Zhou J, 2009, J NEUROSCI, V29, P1773, DOI 10.1523/JNEUROSCI.5685-08.2009
Zhou XP, 2003, AM J HUM GENET, V73, P404, DOI 10.1086/377109
Zori RT, 1998, AM J MED GENET, V80, P399, DOI 10.1002/(SICI)1096-8628(19981204)80:4<399::AID-AJMG18>3.0.CO;2-O
NR 119
TC 16
Z9 17
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD AUG 10
PY 2012
VL 7
IS 8
AR e42504
DI 10.1371/journal.pone.0042504
PG 13
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 986XO
UT WOS:000307380900040
PM 22900024
ER
PT J
AU Mayor, S
AF Mayor, Susan
TI Advertising watchdog orders website to remove claims linking MMR vaccine
with autism
SO BRITISH MEDICAL JOURNAL
LA English
DT News Item
CR BabyJabs, MMR VACC
NR 1
TC 1
Z9 1
PU B M J PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 1756-1833
J9 BRIT MED J
JI Br. Med. J.
PD AUG 9
PY 2012
VL 345
AR e5420
DI 10.1136/bmj.e5420
PG 1
WC Medicine, General & Internal
SC General & Internal Medicine
GA 988NF
UT WOS:000307497000004
PM 22879643
ER
PT J
AU Shamberger, R
AF Shamberger, Raymond
TI Attention-Deficit Disorder Associated with Breast-Feeding: A Brief
Report
SO JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION
LA English
DT Article
DE attention-deficit/hyperactivity disorder (ADHD); breast-feeding;
docosahexaenoic acid (DHA); premature birth; low birth weight babies;
very low birth weight babies
ID DEFICIT/HYPERACTIVITY DISORDER; CHILDREN
AB Background: Attention-deficit/hyperactivity disorder (ADHD) is one of the most common neurodevelopmental disorders that develop in children. In the United States and Canada, the prevalence is about 6%. The causes of ADHD are not known. ADHD, like autism, occurs mainly in boys aged 3-6, and there are some thoughts that both diseases may have a common mechanism.
Methods: This study uses nutritional epidemiology linked to exclusive 6-month breast-feeding. The Centers for Disease Control and Prevention (CDC) has reported in 2003 and 2007 extensive studies on ADHD involving several million children in 50 states. The prevalence of ADHD in each state in 2003 or 2007 was compared to the average of exclusive 6-month breast-feeding from 2001 to 2004 or 3-month exclusive breast-feeding in 2007 in each of the 50 states. Several parameters, such as premature births, low birth weight, and very low birth weight, that had previously associated with ADHD were compared to ADHD incidence. Other parameters such as obesity, infant death rate, neonatal death rate, poverty, per capita income, and the percentage of individuals enrolled in the U.S. WIC (Women, Infants, and Children) program were also compared to ADHD incidence.
Results: A highly significant inverse relationship of ADHD to exclusive 6-month and 3-month breast-feeding in 2007 was observed. Direct relationships were observed between premature births, low birth weight and very low birth weight, obesity, infant deaths, neonatal deaths, and ADHD.
Interpretation: Breast milk contains components that appear to prevent ADHD.
C1 King James Med Lab, Cleveland, OH 44145 USA.
RP Shamberger, R (reprint author), King James Med Lab, 24700 Ctr Ridge Rd, Cleveland, OH 44145 USA.
EM Bobray@ameritech.net
CR Centers for Disease Control and Prevention, 2006, CDC BREAST FEED STAT
Centers for Disease Control and Prevention, OB 2007
Visser S. N., 2010, Morbidity and Mortality Weekly Report, V59, P1439
Hjern A, 2011, PEDIATRICS, V127, P858
Kadziela-Olech H, 2005, Rocz Akad Med Bialymst, V50, P302
Kung Hsiang-Ching, 2008, Natl Vital Stat Rep, V56, P1
Linnet KM, 2006, ARCH DIS CHILD, V91, P655, DOI 10.1136/adc.2005.088872
National Kids Count Program, INF MORT NEON MORT 2
National Kids Count Program, LOW BIRTHW BAB 2007
National Kids Count Program, POV 2007
National Kids Count Program, VER LOW BIRTHW BAB 2
Pelham WE, 2007, J PEDIATR PSYCHOL, V32, P711, DOI 10.1093/jpepsy/jsm022
Shamberger RJ, 2011, J AM COLL NUTR, V30, P348
Sinn A, 2007, J DEV BEHAV PEDIATR, V28, P139
U. S. Department of Agriculture, WIC PROGR TOT PART A
United States Census, 2007, PER CAP INC 2007
Visser S. N., 2003, MMWR-MORBID MORTAL W, V54, P842
NR 17
TC 0
Z9 1
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND
SN 0731-5724
J9 J AM COLL NUTR
JI J. Am. Coll. Nutr.
PD AUG
PY 2012
VL 31
IS 4
BP 239
EP 242
PG 4
WC Nutrition & Dietetics
SC Nutrition & Dietetics
GA 120BM
UT WOS:000317144500002
PM 23378451
ER
PT J
AU Kover, ST
McDuffie, A
Abbeduto, L
Brown, WT
AF Kover, Sara T.
McDuffie, Andrea
Abbeduto, Leonard
Brown, W. Ted
TI Effects of Sampling Context on Spontaneous Expressive Language in Males
With Fragile X Syndrome or Down Syndrome
SO JOURNAL OF SPEECH LANGUAGE AND HEARING RESEARCH
LA English
DT Article
DE language sampling; conversation; narrative; fragile X syndrome; mean
length of utterance (MLU)
ID AUTISM SPECTRUM DISORDERS; WITHIN-SYNDROME DIFFERENCES;
BEHAVIORAL-PHENOTYPE; GENETIC SYNDROMES; YOUNG-CHILDREN; ADOLESCENTS;
SPEECH; BOYS; CONVERSATION; IMPAIRMENT
AB Purpose: In this study, the authors examined the impact of sampling context on multiple aspects of expressive language in male participants with fragile X syndrome in comparison to male participants with Down syndrome or typical development.
Method: Participants with fragile X syndrome (n = 27), ages 10-17 years, were matched groupwise on nonverbal mental age to adolescents with Down syndrome (n = 15) and typically developing 3- to 6-year-olds (n = 15). Language sampling contexts were an interview-style conversation and narration of a wordless book, with scripted examiner behavior. Language was assessed in terms of amount of talk, mean length of communication unit (MLCU), lexical diversity, fluency, and intelligibility.
Results: Participants with fragile X syndrome had lower MLCU and lexical diversity than did participants with typical development. Participants with Down syndrome produced yet lower MLCU. A differential effect of context among those with fragile X syndrome, Down syndrome, and typical development emerged for the number of attempts per minute, MLCU, and fluency. For participants with fragile X syndrome, autism symptom severity related to the number of utterances produced in conversation. Aspects of examiner behavior related to participant performance.
Conclusion: Sampling context characteristics should be considered when assessing expressive language in individuals with neurodevelopmental disabilities.
C1 [Kover, Sara T.] Univ Wisconsin, Waisman Ctr, Madison, WI 53705 USA.
[McDuffie, Andrea; Abbeduto, Leonard] Univ Calif Davis, MIND Inst, Davis, CA 95616 USA.
[Brown, W. Ted] New York State Inst Basic Res Dev Disabil, Staten Isl, NY USA.
RP Kover, ST (reprint author), Univ Wisconsin, Waisman Ctr, Madison, WI 53705 USA.
EM kover@wisc.edu
FU National Institutes of Health (NIH) [R01 HD024356, P30 HD003352];
Waisman Center; Michael Vincent and Harriet Frisbie Eastabrooks O'Shea
Fellowship; NIH [F31 DC010959]
FX This work was supported by National Institutes of Health (NIH) Grants
R01 HD024356 and P30 HD003352, as well as three fellowships awarded to
the first author: the Waisman Center's Anderson Hoffman Wisconsin
Distinguished Graduate Fellowship, the Michael Vincent and Harriet
Frisbie Eastabrooks O'Shea Fellowship, and NIH F31 DC010959 National
Research Service Award Individual Predoctoral Fellowship. Portions of
these data were presented at the 43rd Gatlinburg Conference on Research
and Theory in Intellectual and Developmental Disabilities in Annapolis,
Maryland. We offer our sincere appreciation to all of the families who
participated in this research. We thank Susen Schroeder for her
dedication in supervising the transcription of language samples and
Pamela Lewis for contributing to the autism evaluations.
CR Abbeduto L., 2012, GUIDE RES METHODS CH, P330
Abbeduto L, 2007, MENT RETARD DEV D R, V13, P36, DOI 10.1002/mrdd.20142
ABBEDUTO L, 1995, MENT RETARD, V33, P279
Bailey DB, 1998, J AUTISM DEV DISORD, V28, P499
Barnes E, 2009, J SPEECH LANG HEAR R, V52, P1048, DOI 10.1044/1092-4388(2009/08-0001)
Belser RC, 2001, AM J MENT RETARD, V106, P28, DOI 10.1352/0895-8017(2001)106<0028:CCOCWF>2.0.CO;2
Chapman R S, 2001, Downs Syndr Res Pract, V7, P1, DOI 10.3104/reviews.108
Chapman RS, 2000, MENT RETARD DEV D R, V6, P84, DOI 10.1002/1098-2779(2000)6:2<84::AID-MRDD2>3.0.CO;2-P
Condouris K, 2003, AM J SPEECH-LANG PAT, V12, P349, DOI 10.1044/1058-0360(2003/080)
Cowan P. A., 1967, CHILD DEV, V3, P191
DeThorne LS, 2007, AM J SPEECH-LANG PAT, V16, P119, DOI 10.1044/1058-0360(2007/016)
DOLLAGHAN CA, 1990, J SPEECH HEAR DISORD, V55, P582
Eigsti IM, 2007, J AUTISM DEV DISORD, V37, P1007, DOI 10.1007/s10803-006-0239-2
EVANS JL, 1992, J SPEECH HEAR RES, V35, P343
FERRIER LJ, 1991, DEV MED CHILD NEUROL, V33, P776
Finestack LH, 2010, J SPEECH LANG HEAR R, V53, P1334, DOI 10.1044/1092-4388(2010/09-0125)
Gotham K, 2009, J AUTISM DEV DISORD, V39, P693, DOI 10.1007/s10803-008-0674-3
Hagerman R., 2008, SPEECH LANGUAGE DEV, P27
HAGERMAN RJ, 1986, AM J MED GENET, V23, P359, DOI 10.1002/ajmg.1320230128
Hall SS, 2010, J AM ACAD CHILD PSY, V49, P921, DOI 10.1016/j.jaac.2010.07.001
HANSON DM, 1986, AM J MED GENET, V23, P195, DOI 10.1002/ajmg.1320230114
Hansson K, 2000, INT J LANG COMM DIS, V35, P31
Heilmann J, 2010, LANG SPEECH HEAR SER, V41, P393, DOI 10.1044/0161-1461(2009/09-0023)
Hepburn S, 2008, J APPL RES INTELLECT, V21, P48, DOI 10.1111/j.1468-3148.2007.00368.x
Johnston JR, 2001, J SPEECH LANG HEAR R, V44, P156, DOI 10.1044/1092-4388(2001/014)
JOHNSTON JR, 1993, J SPEECH HEAR RES, V36, P973
Keller-Bell YD, 2007, AM J MENT RETARD, V112, P289, DOI 10.1352/0895-8017(2007)112[289:NDIAAY]2.0.CO;2
Kent L, 1999, DEV MED CHILD NEUROL, V41, P153, DOI 10.1017/S001216229900033X
Kover S. T., 2008, 41 ANN GATL C RES TH
Kover ST, 2010, J INTELL DISABIL RES, V54, P246, DOI 10.1111/j.1365-2788.2010.01255.x
Laws G, 2003, J SPEECH LANG HEAR R, V46, P1324, DOI 10.1044/1092-4388(2003/103)
Leadholm B. J., 1992, LANUGAGE SAMPLE ANAL
Levy Y, 2006, J CHILD LANG, V33, P125, DOI 10.1017/S030500090500718X
Loban W., 1976, LANGUAGE DEV KINDERG
Lord C., 1999, AUTISM DIAGNOSTIC OB
Losh M, 2003, J AUTISM DEV DISORD, V33, P239, DOI 10.1023/A:1024446215446
MACLACHLAN BG, 1988, J SPEECH HEAR DISORD, V53, P2
Mayer M, 1973, FROG HIS OWN
Mayer M., 1974, FROG GOES DINNER
McDuffie A, 2012, AJIDD-AM J INTELLECT, V117, P18, DOI 10.1352/1944-7558-117.1.18
McDuffie A, 2010, AJIDD-AM J INTELLECT, V115, P307, DOI 10.1352/1944-7558-115.4.307
Mervis CB, 1999, MONOGR SOC RES CHILD, V64, P115, DOI 10.1111/1540-5834.00011
Mervis CB, 2005, APPL PSYCHOLINGUIST, V26, P41, DOI 10.1017/S0142716405050058
Miles S, 2006, J SPEECH LANG HEAR R, V49, P325, DOI 10.1044/1092-4388(2006/026)
Miller J. F., 1996, ASSESSMENT COMMUNICA, V6, P309
Miller JF, 2006, SYSTEMATIC ANAL LANG
Moss J, 2009, J INTELL DISABIL RES, V53, P852, DOI 10.1111/j.1365-2788.2009.01197.x
PAUL R, 1984, J SPEECH HEAR DISORD, V49, P328
Pierpont EI, 2011, J NEURODEV DISORD, V3, P335, DOI 10.1007/s11689-011-9095-2
Price JR, 2008, J SPEECH LANG HEAR R, V51, P3, DOI 10.1044/1092-4388(2008/001)
Rice ML, 2010, J SPEECH LANG HEAR R, V53, P333, DOI 10.1044/1092-4388(2009/08-0183)
Roberts J, 2007, AM J MENT RETARD, V112, P177, DOI 10.1352/0895-8017(2007)112[177:RVEVAS]2.0.CO;2
Roberts J, 2007, J SPEECH LANG HEAR R, V50, P475, DOI 10.1044/1092-4388(2007/033)
Roberts JE, 2007, AM J MENT RETARD, V112, P1, DOI 10.1352/0895-8017(2007)112[1:ELDCSI]2.0.CO;2
Rogers SJ, 2001, J DEV BEHAV PEDIATR, V22, P409
Roid G., 1997, LEITER INT PERFORMAN
SCARBOROUGH HS, 1990, APPL PSYCHOLINGUIST, V11, P1, DOI 10.1017/S0142716400008262
SCARBOROUGH HS, 1991, APPL PSYCHOLINGUIST, V12, P23, DOI 10.1017/S014271640000936X
SHAFFER JP, 1986, J AM STAT ASSOC, V81, P826, DOI 10.2307/2289016
Southwood F, 2004, J SPEECH LANG HEAR R, V47, P366, DOI 10.1044/1092-4388(2004/030)
TAGERFLUSBERG H, 1991, J CHILD PSYCHOL PSYC, V32, P1123, DOI 10.1111/j.1469-7610.1991.tb00353.x
Tager-Flusberg H, 2009, J SPEECH LANG HEAR R, V52, P643, DOI 10.1044/1092-4388(2009/08-0136)
Thordardottir E, 2008, J SPEECH LANG HEAR R, V51, P922, DOI 10.1044/1092-4388(2008/068)
Ukrainetz T. A., 2002, CHILD LANG TEACH THE, V18, P59, DOI DOI 10.1191/0265659002CT227OA
Van Borsel J, 2008, CLIN LINGUIST PHONET, V22, P1, DOI 10.1080/02699200701601997
VERKERK AJMH, 1991, CELL, V65, P905, DOI 10.1016/0092-8674(91)90397-H
Wagner CR, 2000, INT J LANG COMM DIS, V35, P83
Westerveld M. F., 2004, ADV SPEECH LANGUAGE, V6, P195, DOI 10.1080/14417040400010140
NR 68
TC 8
Z9 10
PU AMER SPEECH-LANGUAGE-HEARING ASSOC
PI ROCKVILLE
PA 10801 ROCKVILLE PIKE, ROCKVILLE, MD 20852-3279 USA
SN 1092-4388
J9 J SPEECH LANG HEAR R
JI J. Speech Lang. Hear. Res.
PD AUG 1
PY 2012
VL 55
IS 4
BP 1022
EP 1038
DI 10.1044/1092-4388(2011/11-0075)
PG 17
WC Audiology & Speech-Language Pathology; Linguistics; Rehabilitation
SC Audiology & Speech-Language Pathology; Linguistics; Rehabilitation
GA 084GK
UT WOS:000314526300003
PM 22232386
ER
PT J
AU van Rees, LJ
Ballard, KJ
McCabe, P
Macdonald-D'Silva, AG
Arciuli, J
AF van Rees, Lauren J.
Ballard, Kirrie J.
McCabe, Patricia
Macdonald-D'Silva, Anita G.
Arciuli, Joanne
TI Training Production of Lexical Stress in Typically Developing Children
Using Orthographically Biased Stimuli and Principles of Motor Learning
SO AMERICAN JOURNAL OF SPEECH-LANGUAGE PATHOLOGY
LA English
DT Article
DE prosody; lexical stress; stress assignment; speech production; learning
ID AUTISM SPECTRUM DISORDERS; CHILDHOOD APRAXIA; WORD RECOGNITION; SPEECH;
PROSODY; SPEAKERS; ENGLISH; ACCOUNT
AB Purpose: Impaired lexical stress production characterizes multiple pediatric speech disorders. Effective remediation strategies are not available, and little is known about the normal process of learning to assign and produce lexical stress. This study examined whether typically developing (TD) children can be trained to produce lexical stress on bisyllabic pseudowords that are orthographically biased to a strong-weak or weak-strong pattern (e. g., MAMbey or beDOON), in combination with the principles of motor learning (PML).
Method: Fourteen TD children ages 5; 0 (years; months) to 13; 0 were randomly assigned to a training or control group using concealed allocation within blocks. A pre- to post-training group design was used to examine the acquisition, retention, and generalization of lexical stress production.
Results: The training group learned to produce appropriate lexical stress for the pseudowords with strong maintenance and generalization to related untrained stimuli. Accuracy of stress production did not change in the control group.
Conclusion: TD children can learn to produce lexical stress patterns for orthographically biased pseudowords via explicit training methods. Findings have relevance for the study of languages other than English and for a range of prosodic disorders.
C1 [van Rees, Lauren J.; Ballard, Kirrie J.; McCabe, Patricia; Macdonald-D'Silva, Anita G.; Arciuli, Joanne] Univ Sydney, Sydney, NSW 2006, Australia.
RP Ballard, KJ (reprint author), Univ Sydney, Sydney, NSW 2006, Australia.
EM ballard@sydney.edu.au
CR Adams SG, 2000, J MED SPEECH-LANG PA, V8, P215
American Speech-Language-Hearing Association, 1997, GUID AUD SCREEN
Arciuli J, 2006, Q J EXP PSYCHOL, V59, P920, DOI 10.1080/02724980443000782
Arciuli J, 2003, LANG SPEECH, V46, P353
Arciuli J, 2007, NEUROPSYCHOLOGIA, V45, P2638, DOI 10.1016/j.neuropsychologia.2007.03.010
Arciuli J, 2010, J MEM LANG, V63, P180, DOI 10.1016/j.jml.2010.03.005
Arciuli J, 2004, MEM COGNITION, V32, P21, DOI 10.3758/BF03195817
Ballard KJ, 2010, J SPEECH LANG HEAR R, V53, P1227, DOI 10.1044/1092-4388(2010/09-0130)
Ballard KJ, 2000, APHASIOLOGY, V14, P969
Beasley TM, 2002, MULTIVAR BEHAV RES, V37, P197, DOI 10.1207/S15327906MBR3702_02
Cutler A., 1987, Computer Speech and Language, V2, DOI 10.1016/0885-2308(87)90004-0
Cooper N, 2002, LANG SPEECH, V45, P207
Crystal D., 2009, INT J SPEECH LANGUAG, V11, P257
Davis BL, 2000, CHILD DEV, V71, P1258, DOI 10.1111/1467-8624.00227
Duffy J.R, 2005, MOTOR SPEECH DISORDE
Dunn L. M., 1997, PEABODY PICTURE VOCA, V3rd
Fox Cynthia M., 2006, Seminars in Speech and Language, V27, P283, DOI 10.1055/s-2006-955118
GERKEN L, 1994, J CHILD LANG, V21, P565
Gozzard H., 2006, ACQUIRING KNOWLEDGE, V8, P113
Grigos MI, 2007, J SPEECH LANG HEAR R, V50, P119, DOI 10.1044/1092-4388(2007/010)
Gupta P, 2004, BEHAV RES METH INS C, V36, P599, DOI 10.3758/BF03206540
Hargrove P., 2009, INT J SPEECH LANGUAG, V11, P298, DOI DOI 10.1080/17549500902969477
JUSCZYK PW, 1993, CHILD DEV, V64, P675, DOI 10.1111/j.1467-8624.1993.tb02935.x
KELLY MH, 1988, J EXP PSYCHOL HUMAN, V14, P389, DOI 10.1037/0096-1523.14.3.389
Klopfenstein M., 2009, INT J SPEECH LANGUAG, V11, P326
Knock TR, 2000, APHASIOLOGY, V14, P653
Lenden JM, 2007, J COMMUN DISORD, V40, P66, DOI 10.1016/j.jcomdis.2006.04.004
Lewis BA, 2004, LANG SPEECH HEAR SER, V35, P122, DOI 10.1044/0161-1461(2004/014)
Long S. H., 2006, COMPUTERIZED PROFILI
Low E., 2000, LANG SPEECH, V43, P377
Maas E, 2008, AM J SPEECH-LANG PAT, V17, P277, DOI 10.1044/1058-0360(2008/025)
McCabe P., 2010, MOT SPEECH C SAV GA
McCann J, 2007, INT J LANG COMM DIS, V42, P682, DOI 10.1080/13682820601170102
McGregor KK, 1997, J SPEECH LANG HEAR R, V40, P1220
McNeil MR, 1997, CLIN MANAGEMENT SENS, P311
McNeill BC, 2009, INT J LANG COMM DIS, V44, P175, DOI 10.1080/13682820801997353
Paul R, 2005, J AUTISM DEV DISORD, V35, P861, DOI 10.1007/s10803-005-0031-8
Paul R, 2005, J AUTISM DEV DISORD, V35, P205, DOI 10.1007/s10803-005-1999-9
Peppe S. J. E., 2009, INT J SPEECH LANGUAG, V11, P258, DOI DOI 10.1080/17549500902906339
ROBBINS J, 1987, J SPEECH HEAR DISORD, V52, P271
Schiller NO, 2004, BRAIN LANG, V90, P231, DOI 10.1016/S0093-934X(03)00436-X
Schmidt R, 2005, MOTOR CONTROL LEARNI
Schmidt RA, 2008, MOTOR LEARNING PERFO
Semel E., 2006, CLIN EVALUATION LANG, V4th
Sereno J. A., 1986, J ACOUST SOC AM, V79, pS36, DOI 10.1121/1.2023191
Shea R. L., 2001, CHILD LANG TEACH THE, V17, P55, DOI 10.1191/026565901668193508
SHRIBERG LD, 1990, J SPEECH HEAR RES, V33, P627
Shriberg LD, 1997, J SPEECH LANG HEAR R, V40, P313
Shriberg LD, 2003, CLIN LINGUIST PHONET, V17, P549, DOI 10.1080/0269920031000138123
SLOWIACZEK LM, 1990, LANG SPEECH, V33, P47
Slowiaczek LM, 2006, J PSYCHOLINGUIST RES, V35, P491, DOI 10.1007/s10936-006-9026-7
Smith AB, 2005, CLIN LINGUIST PHONET, V19, P1, DOI 10.1080/0269920042000193580
Snow D, 2007, J CHILD LANG, V34, P765, DOI 10.1017/S030500090700815X
Snow D, 1998, J SPEECH LANG HEAR R, V41, P1171
Teverovsky EG, 2009, DISABIL REHABIL, V31, P94, DOI 10.1080/09638280701795030
Woodcock R., 1987, WOODCOCK READING MAS
Zaretsky E, 2010, INT J SPEECH-LANG PA, V12, P58, DOI 10.3109/17549500903216720
NR 57
TC 2
Z9 2
PU AMER SPEECH-LANGUAGE-HEARING ASSOC
PI ROCKVILLE
PA 10801 ROCKVILLE PIKE, ROCKVILLE, MD 20852-3279 USA
SN 1058-0360
J9 AM J SPEECH-LANG PAT
JI Am. J. Speech-Lang. Pathol.
PD AUG 1
PY 2012
VL 21
IS 3
BP 197
EP 206
DI 10.1044/1058-0360(2012/11-0008)
PG 10
WC Audiology & Speech-Language Pathology; Linguistics; Rehabilitation
SC Audiology & Speech-Language Pathology; Linguistics; Rehabilitation
GA 083JV
UT WOS:000314460400003
PM 22411774
ER
PT J
AU Latham, KE
Sapienza, C
Engel, N
AF Latham, Keith E.
Sapienza, Carmen
Engel, Nora
TI The epigenetic lorax: gene-environment interactions in human health
SO EPIGENOMICS
LA English
DT Review
DE aging; behavior; DNA methylation; endocrine disruptors; maternal diet;
windows of sensitivity
ID MAMMARY-GLAND DEVELOPMENT; IN-UTERO EXPOSURE; BISPHENOL-A BPA; BODY-MASS
INDEX; LONG-EVANS RATS; ENDOCRINE-DISRUPTING COMPOUNDS; STEM-CELL
DIFFERENTIATION; GENOME-WIDE ASSOCIATION; FEMALE WISTAR RATS;
LOW-PROTEIN DIET
AB Over the last decade, we have witnessed an explosion of information on genetic factors underlying common human diseases and disorders. This 'human genomics' information revolution has occurred as a backdrop to a rapid increase in the rates of many human disorders and diseases. For example, obesity, Type 2 diabetes, asthma, autism spectrum disorder and attention deficit hyperactivity disorder have increased at rates that cannot be due to changes in the genetic structure of the population, and are difficult to ascribe to changes in diagnostic criteria or ascertainment. A likely cause of the increased incidence of these disorders is increased exposure to environmental factors that modify gene function. Many environmental factors that have epidemiological association with common human disorders are likely to exert their effects through epigenetic alterations. This general mechanism of gene-environment interaction poses special challenges for individuals, educators, scientists and public policy makers in defining, monitoring and mitigating exposures.
C1 [Latham, Keith E.; Sapienza, Carmen; Engel, Nora] Temple Univ, Sch Med, Fels Inst Canc Res & Mol Biol, Philadelphia, PA 19140 USA.
[Latham, Keith E.; Engel, Nora] Temple Univ, Sch Med, Dept Biochem, Philadelphia, PA 19140 USA.
[Sapienza, Carmen] Temple Univ, Sch Med, Dept Pathol & Lab Med, Philadelphia, PA 19140 USA.
RP Latham, KE (reprint author), Temple Univ, Sch Med, Fels Inst Canc Res & Mol Biol, 3400 N Broad St, Philadelphia, PA 19140 USA.
EM klatham@temple.edu
FU NIH National Institute of Child Health and Development [HD43092]; NIH
Office of the Director, Comparative Medicine Branch, Office of Research
Infrastructure Program [R24OD012221-12, U54HD068157, RO1GM093066,
K22CA140361-3]
FX Research in the authors' laboratories is supported in part by grants
from the NIH National Institute of Child Health and Development
(HD43092; KE Latham), the NIH Office of the Director, Comparative
Medicine Branch, Office of Research Infrastructure Program,
R24OD012221-12 (KE Latham), U54HD068157 (C Sapienza), and RO1GM093066
and K22CA140361-3 (N Engel). The authors have no other relevant
affiliations or financial involvement with any organization or entity
with a financial interest in or financial conflict with the subject
matter or materials discussed in the manuscript apart from those
disclosed.
CR Abeyta MJ, 2004, HUM MOL GENET, V13, P601, DOI 10.1093/hmg/ddh068
AGARWAL DK, 1985, J TOXICOL ENV HEALTH, V16, P71
Alissa EM, 2011, J TOXICOL, V2011, DOI [10.1155/2011/87012, DOI 10.1155/2011/870125]
Aloisi AM, 2001, NEUROSCI LETT, V310, P49, DOI 10.1016/S0304-3940(01)02092-4
Alvarez-Buylla A, 2002, BRAIN RES BULL, V57, P751, DOI 10.1016/S0361-9230(01)00770-5
Anas MKI, 2003, REPROD TOXICOL, V17, P305, DOI 10.1016/S0890-6238(03)00014-5
Anckaert E, 2010, BIOL REPROD, V83, P377, DOI 10.1095/biolreprod.109.082164
Angiolini E, 2006, PLACENTA, V27, pS98, DOI 10.1016/j.placenta.2005.12.008
Anier K, 2010, NEUROPSYCHOPHARMACOL, V35, P2450, DOI 10.1038/npp.2010.128
Anway MD, 2005, SCIENCE, V308, P1466, DOI 10.1126/science.1108190
Anway MD, 2008, REPROD TOXICOL, V26, P100, DOI 10.1016/j.reprotox.2008.07.008
Anway MD, 2008, REPROD BIOMED ONLINE, V16, P23
Arase S, 2010, BIOL REPROD, V84, P734
Ashby J, 1998, ENVIRON HEALTH PERSP, V106, P719, DOI 10.1289/ehp.98106719
Ashworth A, 1998, EUR J CLIN NUTR, V52, pS34
Avissar-Whiting M, 2010, REPROD TOXICOL, V29, P401, DOI 10.1016/j.reprotox.2010.04.004
Balabanic D, 2011, REPROD FERT DEVELOP, V23, P403, DOI 10.1071/RD09300
Barker DJP, 2004, J AM COLL NUTR, V23, p588S
BARKER DJP, 1993, LANCET, V341, P938, DOI 10.1016/0140-6736(93)91224-A
BARKER DJP, 1993, DIABETOLOGIA, V36, P62, DOI 10.1007/BF00399095
Barker DJP, 2008, NESTLE NUTR WORKS SE, V61, P21, DOI 10.1159/0000113163
Barker DJP, 2009, ANN HUM BIOL, V36, P445, DOI 10.1080/03014460902980295
BARKER DJP, 1992, J HYPERTENS, V10, pS39
Barrera LO, 2008, GENOME RES, V18, P46, DOI 10.1101/gr.6654808
Barrero MJ, 2010, CELL STEM CELL, V7, P565, DOI 10.1016/j.stem.2010.10.009
BELL FP, 1982, ENVIRON HEALTH PERSP, V45, P41, DOI 10.2307/3429382
Beltrami AP, 2003, CELL, V114, P763, DOI 10.1016/S0092-8674(03)00687-1
Benachour N, 2009, CHEM RES TOXICOL, V22, P97, DOI 10.1021/tx800218n
Benachour N, 2009, TOXICOL APPL PHARM, V241, P322, DOI 10.1016/j.taap.2009.09.005
Bentov Y, 2011, J ASSIST REPROD GEN, V28, P773, DOI 10.1007/s10815-011-9588-7
Berger RG, 2010, REPROD TOXICOL, V30, P393, DOI 10.1016/j.reprotox.2010.06.006
Bernal AJ, 2010, BIRTH DEFECTS RES A, V88, P938, DOI 10.1002/bdra.20685
Birnbaum LS, 2003, ENVIRON HEALTH PERSP, V111, P389, DOI 10.1289/ehp.5686
Bjornsson HT, 2008, JAMA-J AM MED ASSOC, V299, P2877, DOI 10.1001/jama.299.24.2877
Bo E, 2011, NEUROTOXICOLOGY, V32, P277, DOI 10.1016/j.neuro.2010.12.011
Bogdanska J, 2011, TOXICOLOGY, V284, P54, DOI 10.1016/j.tox.2011.03.014
Bollati V, 2009, MECH AGEING DEV, V130, P234, DOI 10.1016/j.mad.2008.12.003
Boyle CA, 2011, PEDIATRICS, V127, P1034, DOI 10.1542/peds.2010-2989
Bryder D, 2006, AM J PATHOL, V169, P338, DOI 10.2353/jmoldx.2006.050079
Brykczynska U, 2010, NAT STRUCT MOL BIOL, V17, P679, DOI 10.1038/nsmb.1821
Carrell DT, 2011, FERTIL STERIL, V97, P267
Champagne FA, 2009, NEUROSCI BIOBEHAV R, V33, P593, DOI 10.1016/j.neubiorev.2007.10.009
Chang SC, 2011, REPROD TOXICOL, V33, P428
Chao HH, 2012, HISTOCHEM CELL BIOL, V137, P249, DOI 10.1007/s00418-011-0894-z
Chauvigne F, 2009, ENVIRON HEALTH PERSP, V117, P515, DOI 10.1289/ehp.11870
Chen GL, 2010, HORM BEHAV, V57, P184, DOI 10.1016/j.yhbeh.2009.10.012
Chen SE, 2006, POULTRY SCI, V85, P70
Chen SQ, 2010, J PERINAT MED, V38, P515, DOI 10.1515/JPM.2010.083
Chen Y, 2011, HUM GENET, V131, P1081
Chen YF, 2008, TOXICOLOGY, V251, P21, DOI 10.1016/j.tox.2008.06.015
Chung CC, 2011, HUM GENET, V130, P59, DOI 10.1007/s00439-011-1030-9
Cirulli F, 2011, PSYCHONEUROENDOCRINO, V36, P372, DOI 10.1016/j.psyneuen.2010.10.019
Constancia M, 2002, NATURE, V417, P945, DOI 10.1038/nature00819
Constancia M, 2005, P NATL ACAD SCI USA, V102, P19219, DOI 10.1073/pnas.0504468103
Cooke GM, 2008, J TOXICOL ENV HEAL A, V71, P384, DOI 10.1080/15287390701801653
Cooney CM, 2008, ENVIRON SCI TECHNOL, V42, P3486, DOI 10.1021/es0871098
Dalman A, 2008, BIOFACTORS, V33, P149, DOI 10.1002/biof.5520330207
DAVIS BJ, 1994, TOXICOL APPL PHARM, V128, P216, DOI 10.1006/taap.1994.1200
Davis TL, 2000, HUM MOL GENET, V9, P2885, DOI 10.1093/hmg/9.19.2885
Daxinger L, 2012, NAT REV GENET, V13, P153, DOI 10.1038/nrg3188
Decherf S, 2011, J TOXICOL ENV HEAL B, V14, P423, DOI 10.1080/10937404.2011.578561
Determination of perfluorooctanoic acid (PFOA) in aqueous samples, 2007, DET PERFL AC PFOA AC
Devlin B, 2011, BRAIN RES, V1380, P78, DOI 10.1016/j.brainres.2010.11.026
Dolinoy DC, 2007, P NATL ACAD SCI USA, V104, P13056, DOI 10.1073/pnas.0703739104
Durmaz E, 2010, PEDIATRICS, V125, pE122, DOI 10.1542/peds.2009-0724
Edwards TM, 2007, ENVIRON HEALTH PERSP, V115, P1264, DOI 10.1289/ehp.9951
Ema M, 1999, TOXICOL LETT, V108, P17, DOI 10.1016/S0378-4274(99)00074-0
Ema M, 2007, ENVIRON TOXICOL, V22, P44, DOI 10.1002/tox.20232
Enoch RR, 2007, ENVIRON HEALTH PERSP, V115, P541, DOI 10.1289/ehp.9612
Eriksson JG, 2007, HYPERTENSION, V49, P1415, DOI 10.1161/HYPERTENSIONAHA.106.085597
Falkenberg VR, 2011, NEUROMOL MED, V13, P66, DOI 10.1007/s12017-010-8138-2
Fenton SE, 2009, REPROD TOXICOL, V27, P365, DOI 10.1016/j.reprotox.2009.02.012
Flegal KM, 2005, JAMA-J AM MED ASSOC, V293, P1861, DOI 10.1001/jama.2009.2014
Fleming TP, 2004, BIOL REPROD, V71, P1046, DOI 10.1095/bioreprod.104.030957
Florentin A, 2011, INT J HYG ENVIR HEAL, V214, P493, DOI 10.1016/j.ijheh.2011.05.010
Foradori CD, 2009, BIOL REPROD, V81, P40, DOI 10.1095/biolreprod.108.075713
Foradori CD, 2011, BIOL REPROD, V85, P684, DOI 10.1095/biolreprod.111.092452
Foradori CD, 2009, BIOL REPROD, V81, P1099, DOI 10.1095/biolreprod.109.077453
Fouladi-Nashta AA, 2009, REPRODUCTION, V138, P771, DOI 10.1530/REP-08-0391
Fowden AL, 2006, HORM RES, V65, P50, DOI 10.1159/000091506
Fraga MF, 2005, P NATL ACAD SCI USA, V102, P10604, DOI 10.1073/pnas.0500398102
Franke B, 2009, HUM GENET, V126, P13, DOI 10.1007/s00439-009-0663-4
Fu HY, 2010, ONCOL REP, V24, P335, DOI 10.3892/or_00000864
Fujimoto VY, 2011, FERTIL STERIL, V95, P1816, DOI 10.1016/j.fertnstert.2010.11.008
Gao Lifang, 2003, Wei Sheng Yan Jiu, V32, P198
Gogvadze V, 2002, BIOCHEM BIOPH RES CO, V292, P904, DOI 10.1006/bbrc.2002.6679
Gojmerac T, 1996, TOXICOL LETT, V85, P9, DOI 10.1016/0378-4274(96)03631-4
Gore AC, 2011, MOL ENDOCRINOL, V25, P2157, DOI 10.1210/me.2011-1210
Graves JE, 2002, J ENVIRON SCI HEAL B, V37, P103, DOI 10.1081/PFC-120002982
Greenlee AR, 2004, ENVIRON HEALTH PERSP, V112, P703, DOI 10.1289/ehp.6774
Groebe K, 2010, J PROTEOME RES, V9, P5727, DOI 10.1021/pr100514e
Grote K, 2007, TOXICOLOGY, V238, P177, DOI 10.1016/j.tox.2007.05.033
Grun F, 2006, MOL ENDOCRINOL, V20, P2141, DOI 10.1210/me.2005-0367
Grun F, 2009, MOL ENDOCRINOL, V23, P1127, DOI 10.1210/me.2008-0485
Grun F, 2006, ENDOCRINOLOGY, V147, pS50, DOI 10.1210/en.2005-1129
Grun F, 2007, REV ENDOCR METAB DIS, V8, P161, DOI 10.1007/s11154-007-9049-x
Guerrero-Bosagna C, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0013100
Gunderson MP, 2011, AQUAT TOXICOL, V102, P31, DOI 10.1016/j.aquatox.2010.12.019
Guo Y, 2011, ENVIRON SCI TECHNOL, V45, P3788, DOI 10.1021/es2002106
Gupta RK, 2010, TOXICOL APPL PHARM, V242, P224, DOI 10.1016/j.taap.2009.10.011
Hammoud SS, 2009, NATURE, V460, P473, DOI 10.1038/nature08162
Harazono A, 2000, ARCH TOXICOL, V74, P632, DOI 10.1007/s002040000163
Hayes TB, 2011, J STEROID BIOCHEM, V127, P64, DOI 10.1016/j.jsbmb.2011.03.015
Heijmans BT, 2009, EPIGENETICS, V4, P526
Hengstler JG, 2011, CRIT REV TOXICOL, V41, P263, DOI 10.3109/10408444.2011.558487
Hochberg Z, 2011, ENDOCR REV, V32, P159, DOI 10.1210/er.2009-0039
Hoffman K, 2010, ENVIRON HEALTH PERSP, V118, P1762, DOI 10.1289/ehp.1001898
Hoffman K, 2011, ENVIRON HEALTH PERSP, V119, P92, DOI 10.1289/ehp.1002503
Hoyo C, 2011, EPIGENETICS-US, V6, P928, DOI 10.4161/epi.6.7.16263
Hsu LI, 2011, J BIOMED SCI, V18, DOI 10.1186/1423-0127-18-51
Hunt PA, 2003, CURR BIOL, V13, P546, DOI 10.1016/S0960-9822(03)00189-1
Hunt PA, 2008, TRENDS GENET, V24, P86, DOI 10.1016/j.tig.2007.11.010
Ichise M, 2006, J NEUROSCI, V26, P4638, DOI 10.1523/JNEUROSCI.5199-05.2006
Imanishi S, 2003, J REPROD DEVELOP, V49, P329
Inadera H, 2005, TOXICOL LETT, V159, P226, DOI 10.1016/j.toxlet.2005.05.015
Janer G, 2008, TOXICOL IN VITRO, V22, P1797, DOI 10.1016/j.tiv.2008.07.007
Janesick A, 2012, INT J ANDROL, V35, P437, DOI 10.1111/j.1365-2605.2012.01247.x
Jensen TJ, 2009, TOXICOL APPL PHARM, V241, P221, DOI 10.1016/j.taap.2009.08.019
Jin H, 2005, PLACENTA, V26, pS96, DOI 10.1016/j.placenta.2005.01.016
Jomova K, 2011, J APPL TOXICOL, V31, P95, DOI 10.1002/jat.1649
JONES HB, 1993, EXP MOL PATHOL, V58, P179, DOI 10.1006/exmp.1993.1016
Jongbloet Piet Hein, 2008, J Exp Clin Assist Reprod, V5, P5, DOI 10.1186/1743-1050-5-5
Juliani CC, 2008, MICRON, V39, P607, DOI 10.1016/j.micron.2007.04.006
Jungheim ES, 2011, FERTIL STERIL, V95, P1970, DOI 10.1016/j.fertnstert.2011.01.154
Jungheim ES, 2008, SEMIN REPROD MED, V26, P186, DOI 10.1055/s-2008-1042957
Jungheim ES, 2009, FERTIL STERIL, V92, P256, DOI 10.1016/j.fertnstert.2008.04.063
Jungheim ES, 2010, ENDOCRINOLOGY, V151, P4039, DOI 10.1210/en.2010-0098
Jungheim ES, 2011, FERTIL STERIL, V96, P880, DOI 10.1016/j.fertnstert.2011.07.1115
Jungheim ES, 2010, AM J OBSTET GYNECOL, V203, P525, DOI 10.1016/j.ajog.2010.06.043
Jurewicz J, 2011, INT J OCCUP MED ENV, V24, P115, DOI 10.2478/s13382-011-0022-2
Kandaraki E, 2011, J CLIN ENDOCR METAB, V96, pE480, DOI 10.1210/jc.2010-1658
Kang ER, 2011, EPIGENETICS-US, V6, P937, DOI 10.4161/epi.6.7.16067
KANNAN K, 1995, B ENVIRON CONTAM TOX, V55, P510
Kannan K, 2010, ARCH ENVIRON CON TOX, V58, P901, DOI 10.1007/s00244-010-9513-6
Kim BN, 2009, BIOL PSYCHIAT, V66, P958, DOI 10.1016/j.biopsych.2009.07.034
Kinnally EL, 2010, GENES BRAIN BEHAV, V9, P575, DOI 10.1111/j.1601-183X.2010.00588.x
Kirchner S, 2010, MOL ENDOCRINOL, V24, P526, DOI 10.1210/me.2009-0261
Kishta O, 2007, REPROD TOXICOL, V23, P1, DOI 10.1016/j.reprotox.2006.08.014
Kmetic I, 2008, B ENVIRON CONTAM TOX, V81, P205, DOI 10.1007/s00128-008-9425-6
Kuegler PB, 2010, ALTEX-ALTERN ANIM EX, V27, P17
Kwong WY, 2007, MOL REPROD DEV, V74, P48, DOI 10.1002/mrd.20606
Kwong WY, 2006, REPRODUCTION, V132, P265, DOI 10.1530/rep.1.01038
Laanpere M, 2010, NUTR REV, V68, P99, DOI 10.1111/j.1753-4887.2009.00266.x
Labonte B, 2010, ARCH SUICIDE RES, V14, P291, DOI 10.1080/13811118.2010.524025
LaPlant Q, 2010, NAT NEUROSCI, V13, P1137, DOI 10.1038/nn.2619
Latini G, 2003, ENVIRON HEALTH PERSP, V111, P1783, DOI 10.1289/ehp.6202
Latini G, 2006, CURR MED CHEM, V13, P2527, DOI 10.2174/092986706778201666
Launay JM, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0007959
Lawson C, 2011, BIOL REPROD, V84, P79, DOI 10.1095/biolreprod.110.084814
Lee J, 2004, TOXICOL LETT, V152, P1, DOI 10.1016/j.toxlet.2004.03.011
Lee RS, 2011, PSYCHOPHARMACOLOGY, V218, P303, DOI 10.1007/s00213-011-2307-3
Lees-Murdock DJ, 2008, ADV EXP MED BIOL, V626, P1
Lenie S, 2008, MUTAT RES-GEN TOX EN, V651, P71, DOI 10.1016/j.mrgentox.2007.10.017
Li X, 2011, J STEROID BIOCHEM, V127, P9, DOI 10.1016/j.jsbmb.2011.03.012
Liao CY, 2011, ENVIRON SCI TECHNOL, V45, P6761, DOI 10.1021/es200977t
Lin LC, 2011, CHEMOSPHERE, V83, P1192, DOI 10.1016/j.chemosphere.2010.12.079
Lin ZM, 2011, TOXICOL APPL PHARM, V251, P16, DOI 10.1016/j.taap.2010.11.009
Lind PM, 2011, ATHEROSCLEROSIS, V218, P207, DOI 10.1016/j.atherosclerosis.2011.05.001
Lindell SG, 2010, ARCH GEN PSYCHIAT, V67, P423, DOI 10.1001/archgenpsychiatry.2010.23
Lindstrom AB, 2011, ENVIRON SCI TECHNOL, V45, P7954, DOI 10.1021/es2011622
Liu Gilbert C, 2002, Proc AMIA Symp, P459
Liu YL, 2009, EPIGENETICS, V4, P500
Loganathan BG, 1999, CHEMOSPHERE, V39, P2401, DOI 10.1016/S0045-6535(99)00167-8
Loganathan SN, 2011, ARCH ENVIRON CON TOX, V61, P68, DOI 10.1007/s00244-010-9634-y
Lovekamp-Swan T, 2003, ENVIRON HEALTH PERSP, V111, P139
Lu Y, 2010, ENVIRON SCI TECHNOL, V44, P6081, DOI 10.1021/es101368n
Ma J., 2009, CHINA ENV SCI, V43, P7350, DOI DOI 10.1021/ES901713U
Madrigano J, 2012, EPIGENETICS-US, V7, P63, DOI 10.4161/epi.7.1.18749
Maegawa S, 2010, GENOME RES, V20, P332, DOI 10.1101/gr.096826.109
Maranghi F, 2010, REPROD TOXICOL, V29, P427, DOI 10.1016/j.reprotox.2010.03.002
Marquard KL, 2011, FERTIL STERIL, V95, P2146, DOI 10.1016/j.fertnstert.2010.10.026
Martin SA, 2011, OXID MED CELL LONGEV, DOI 10.1155/2011/935160
Martinez VD, 2011, MOL BIOL INT, V2011, DOI DOI 10.4061/2011/718974
Martinez-Finley EJ, 2011, NEUROTOXICOL TERATOL, V33, P530, DOI 10.1016/j.ntt.2011.07.003
Maze I, 2011, P NATL ACAD SCI USA, V108, P3035, DOI 10.1073/pnas.1015483108
McKee RH, 2004, ENVIRON HEALTH PERSP, V112, pA541
Meeker JD, 2011, ENVIRON HEALTH PERSP, V119, P1396, DOI 10.1289/ehp.1103582
Metges CC, 2009, ADV EXP MED BIOL, V646, P105, DOI 10.1007/978-1-4020-9173-5_11
Mikkelsen TS, 2007, NATURE, V448, P553, DOI 10.1038/nature06008
Moon HJ, 2007, J REPROD DEVELOP, V53, P333, DOI 10.1262/jrd.18055
Morice L, 2011, REPROD TOXICOL, V32, P69, DOI 10.1016/j.reprotox.2011.05.003
Muhlhauser A, 2009, BIOL REPROD, V80, P1066, DOI 10.1095/biolreprod.108.074815
Munger R, 1997, ENVIRON HEALTH PERSP, V105, P308, DOI 10.1289/ehp.97105308
Murata S, 2008, MAR POLLUT BULL, V56, P641, DOI 10.1016/j.marpolbul.2008.01.019
NAVOT D, 1994, FERTIL STERIL, V61, P97
Newman TK, 2005, BIOL PSYCHIAT, V57, P167, DOI 10.1016/j.biopsych.2004.10.012
Nishizawa H, 2005, J REPROD DEVELOP, V51, P315, DOI 10.1262/jrd.16008
Nohara K, 2011, ARCH TOXICOL, V85, P653, DOI 10.1007/s00204-010-0611-z
Oberlander TF, 2008, EPIGENETICS, V3, P97
Ochoa-Acuna H, 2009, ENVIRON HEALTH PERSP, V117, P1619, DOI 10.1289/ehp.0900784
Office of Environmental Health Hazard Assessment California Environmental Protection Agency, 1999, PUBL HLTH GOAL ATR D
Ogden C., 2010, PREVALENCE OBESITY C
Ogden CL, 2002, JAMA-J AM MED ASSOC, V288, P1728, DOI 10.1001/jama.2012.40
Ogden CL, 2012, PREVALENCE OBESITY U
Ogden CL, 2010, JAMA-J AM MED ASSOC, V303, P242, DOI 10.1001/jama.2009.2012
Ohno S, 2005, STEROIDS, V70, P645, DOI 10.1016/j.steroids.2005.03.005
Okasha M, 2001, ANN HUM BIOL, V28, P68
Olsen GW, 2009, REPROD TOXICOL, V27, P212, DOI 10.1016/j.reprotox.2009.02.001
Ortiz-Mantilia S, 2008, DEV PSYCHOBIOL, V50, P107, DOI 10.1002/dev.20278
Orton F, 2009, ENVIRON SCI TECHNOL, V43, P2144, DOI 10.1021/es8028928
Osafune K, 2008, NAT BIOTECHNOL, V26, P313, DOI 10.1038/nbt1383
Ourednik J, 2002, NAT BIOTECHNOL, V20, P1103, DOI 10.1038/nbt750
Padros J, 2003, TOXICOL APPL PHARM, V192, P45, DOI 10.1016/S0041-008X(02)00042-X
Pavlikova N, 2010, AQUAT TOXICOL, V99, P176, DOI 10.1016/j.aquatox.2010.04.014
Peden-Adams MM, 2008, TOXICOL SCI, V104, P144, DOI 10.1093/toxsci/kfn059
Philibert RA, 2008, AM J MED GENET B, V147B, P565, DOI 10.1002/ajmg.b.30778
Philibert RA, 2011, BIOL PSYCHOL, V87, P366, DOI 10.1016/j.biopsycho.2011.04.007
Philibert RA, 2010, AM J MED GENET B, V153B, P619, DOI 10.1002/ajmg.b.31031
Pinchuk LM, 2007, TOXICOL APPL PHARM, V223, P206, DOI 10.1016/j.taap.2007.06.004
Poulsen P, 2007, PEDIATR RES, V61, p38R, DOI 10.1203/pdr.0b013e31803c7b98
Purcell SH, 2011, J ASSIST REPROD GEN, V28, P517, DOI 10.1007/s10815-011-9592-y
Rappolee DA, 2012, SYST BIOL REPROD MED, V58, P33, DOI 10.3109/19396368.2011.647381
Rayner JL, 2005, TOXICOL SCI, V87, P255, DOI 10.1093/toxsci/kfi213
Rayner JL, 2004, TOXICOL APPL PHARM, V195, P23, DOI 10.1016/j.taap.2003.11.005
Rayner JL, 2007, TOXICOL APPL PHARM, V218, P238, DOI 10.1016/j.taap.2006.11.020
Reik W, 2001, NOVART FDN SYMP, V237, P19, DOI 10.1002/0470846666.ch3
Reik W, 2003, J PHYSIOL-LONDON, V547, P35, DOI 10.1113/jphysiol.2002.033274
Rice Catherine, 2009, Morbidity and Mortality Weekly Report, V58, P1
Rice CE, 2011, AM FAM PHYSICIAN, V83, P515
Richter CA, 2007, REPROD TOXICOL, V24, P199, DOI 10.1016/j.reprotox.2007.06.004
Rodriguez HA, 2010, REPROD TOXICOL, V30, P550, DOI 10.1016/j.reprotox.2010.07.008
Roepke TA, 2005, AQUAT TOXICOL, V71, P155, DOI 10.1016/j.aquatox.2004.11.003
Roth TL, 2011, J PSYCHIATR RES, V45, P919, DOI 10.1016/j.jpsychires.2011.01.013
Rowe AM, 2006, TOXICOL APPL PHARM, V214, P69, DOI 10.1016/j.taap.2005.12.006
Rowe AM, 2008, BASIC CLIN PHARMACOL, V102, P139, DOI 10.1111/j.1742-7843.2007.00175.x
Rowe AM, 2007, TOXICOL APPL PHARM, V221, P179, DOI 10.1016/j.taap.2007.01.012
Rubin BS, 2006, ENDOCRINOLOGY, V147, P3681, DOI 10.1210/en.2006-0189
Rubin BS, 2011, J STEROID BIOCHEM, V127, P27, DOI 10.1016/j.jsbmb.2011.05.002
Rudel RA, 2003, ENVIRON SCI TECHNOL, V37, P4543, DOI 10.1021/es0264596
Sachdev HPS, 2009, ARCH DIS CHILD, V94, P768, DOI 10.1136/adc.2008.140905
Sandovici I, 2004, HUM GENET, V115, P387, DOI 10.1007/s00439-004-1177-8
Sandovici I, 2004, HUM MOL GENET, V13, P781, DOI 10.1093/hmg/ddh097
Sapienza C, 2011, EPIGENETICS-US, V6, P20, DOI 10.4161/epi.6.1.13362
Sauer MV, 1998, MATURITAS, V30, P221, DOI 10.1016/S0378-5122(98)00077-2
Schug TT, 2011, J STEROID BIOCHEM, V127, P204, DOI 10.1016/j.jsbmb.2011.08.007
Schwandt ML, 2011, PSYCHONEUROENDOCRINO, V36, P1303, DOI 10.1016/j.psyneuen.2011.03.002
Scott LJ, 2007, SCIENCE, V316, P1341, DOI 10.1126/science.1142382
Seidlova-Wuttke D, 2004, TOXICOLOGY, V205, P103, DOI 10.1016/j.tox.2004.06.042
Seiler A, 2004, REPROD TOXICOL, V18, P231, DOI 10.1016/j.reprotox.2003.10.015
Selesniemi K, 2011, P NATL ACAD SCI USA, V108, P12319, DOI 10.1073/pnas.1018793108
Shapira Niva, 2008, Womens Health (Lond Engl), V4, P639, DOI 10.2217/17455057.4.6.639
SHERINS RJ, 1995, FERTIL STERIL, V64, P369
Shumay E, 2010, EPIGENETICS-US, V5, P325
Silviera ML, 2012, CANCER PREV RES, V5, P374, DOI 10.1158/1940-6207.CAPR-11-0336
Skinner MK, 2011, REPROD TOXICOL, V31, P337, DOI 10.1016/j.reprotox.2010.10.012
Smeester L, 2011, CHEM RES TOXICOL, V24, P165, DOI 10.1021/tx1004419
Solari M, 2010, TOXICOL SCI, V113, P116, DOI 10.1093/toxsci/kfp243
Speliotes EK, 2010, NAT GENET, V42, P937, DOI 10.1038/ng.686
SPEROFF L, 1994, CURR OPIN OBSTET GYN, V6, P115
Spiegelman BM, 2001, CELL, V104, P531, DOI 10.1016/S0092-8674(01)00240-9
Spinelli S, 2010, BIOL PSYCHIAT, V67, P1146, DOI 10.1016/j.biopsych.2009.12.030
Stanko JP, 2010, REPROD TOXICOL, V30, P540, DOI 10.1016/j.reprotox.2010.07.006
Stein CR, 2009, AM J EPIDEMIOL, V170, P837, DOI 10.1093/aje/kwp212
Struve MF, 2009, BIRTH DEFECTS RES B, V86, P345, DOI 10.1002/bdrb.20199
Su YQ, 2008, DEVELOPMENT, V135, P111, DOI 10.1242/dev.009068
Suzawa M, 2008, PLOS ONE, V3, DOI 10.1371/journal.pone.0002117
Suzuki N, 2011, J TOXICOL SCI, V36, P569
Swan SH, 2010, INT J ANDROL, V33, P259, DOI 10.1111/j.1365-2605.2009.01019.x
Szyf M, 2008, ENVIRON MOL MUTAGEN, V49, P46, DOI 10.1002/em.20357
Szyf M, 2011, EPIGENETICS-US, V6, P971, DOI 10.4161/epi.6.8.16793
Szyf M, 2009, BBA-GEN SUBJECTS, V1790, P878, DOI 10.1016/j.bbagen.2009.01.009
Tachibana T, 2007, J REPROD DEVELOP, V53, P509, DOI 10.1262/jrd.18171
Takai Y, 2001, REPROD TOXICOL, V15, P71
Takeda Y, 2009, J BIOCHEM, V146, P113, DOI 10.1093/jb/mvp049
Tesarik J, 2005, REPROD BIOMED ONLINE, V10, P370
Thomas P, 2008, MAR ENVIRON RES, V66, P1, DOI 10.1016/j.marenvres.2008.02.005
Todd JL, 2011, AM J RESP CRIT CARE, V184, P873, DOI 10.1164/rccm.201106-0971PP
Trounson A, 2006, ENDOCR REV, V27, P208, DOI 10.1210/er.2005-0016
Ueda T, 2000, GENES CELLS, V5, P649, DOI 10.1046/j.1365-2443.2000.00351.x
U.S. Environmental Protection Agency Office of Pesticide Programs Health Effects Division and Environmental Fate and Effects Division in collaboration with the Office of Research and Development Re-Evaluation of Human Health Effects of Atrazine, 2010, FED INS FUNG NROD AC
Van Hoeck V, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0023183
van Dartel DAM, 2011, TOXICOL LETT, V201, P143, DOI 10.1016/j.toxlet.2010.12.019
van Dartel DAM, 2011, TOXICOL SCI, V119, P126, DOI 10.1093/toxsci/kfq291
Vandenberg LN, 2010, ENVIRON HEALTH PERSP, V118, P1055, DOI 10.1289/ehp.0901716
Vandenberg LN, 2008, REPROD TOXICOL, V26, P210, DOI 10.1016/j.reprotox.2008.09.015
Vandenberg LN, 2007, REPROD TOXICOL, V24, P139, DOI 10.1016/j.reprotox.2007.07.010
Vandenberg LN, 2007, ENDOCRINOLOGY, V148, P116, DOI 10.1210/en.2006-0561
Vandenberg LN, 2010, ENVIRON HEALTH PERSP, V118, P1051, DOI 10.1289/ehp.0901717
Varayoud J, 2011, ENDOCRINOLOGY, V152, P1101, DOI 10.1210/en.2009-1037
Villanueva CM, 2005, OCCUP ENVIRON MED, V62, P400, DOI 10.1136/oem.2004.016469
Volarcik K, 1998, HUM REPROD, V13, P154, DOI 10.1093/humrep/13.1.154
Wadia PR, 2007, ENVIRON HEALTH PERSP, V115, P592, DOI 10.1289/ehp.9640
Wang Q, 2009, MOL ENDOCRINOL, V23, P1603, DOI 10.1210/me.2009-0033
Wang QA, 2010, MITOCHONDRION, V10, P403, DOI 10.1016/j.mito.2010.03.002
Wang XL, 2011, CURR HYPERTENS REP, V13, P442, DOI 10.1007/s11906-011-0230-y
Waterland RA, 2010, PLOS GENET, V6, DOI 10.1371/journal.pgen.1001252
Waterland RA, 2006, GENESIS, V44, P401, DOI 10.1002/dvg.20230
Waterland RA, 2006, HUM MOL GENET, V15, P705, DOI 10.1093/hmg/ddi484
Watkins AJ, 2007, P NATL ACAD SCI USA, V104, P5449, DOI 10.1073/pnas.0610317104
Watkins AJ, 2008, BIOL REPROD, V78, P299, DOI 10.1095/biolreprod.107.064220
Watkins AJ, 2008, J PHYSIOL-LONDON, V586, P2231, DOI 10.1113/jphysiol.2007.149229
Weng YI, 2010, TOXICOL APPL PHARM, V248, P111, DOI 10.1016/j.taap.2010.07.014
White SS, 2011, J STEROID BIOCHEM, V127, P16, DOI 10.1016/j.jsbmb.2011.03.011
White SS, 2009, REPROD TOXICOL, V27, P289, DOI 10.1016/j.reprotox.2008.11.054
White SS, 2011, ENVIRON HEALTH PERSP, V119, P1070, DOI 10.1289/ehp.1002741
White SS, 2007, TOXICOL SCI, V96, P133, DOI 10.1093/toxsci/kfl177
Wilson S, 2004, ENVIRON TOXICOL, V19, P554, DOI 10.1002/tox.20061
Wise DD, 2006, J CHROMATOGR A, V1111, P153, DOI 10.1016/j.chroma.2005.07.067
Wolf AM, 2009, AM J MED, V122, pS19, DOI 10.1016/j.amjmed.2009.01.004
Wolf CJ, 2007, TOXICOL SCI, V95, P462, DOI 10.1093/toxsci/kfl159
World Health Organization, WHO OB OV
Wu JL, 2011, J ENVIRON HEALTH, V74, P20
Wu LLY, 2010, ENDOCRINOLOGY, V151, P5438, DOI 10.1210/en.2010-0551
Xiao S, 2011, REPROD TOXICOL, V32, P434, DOI 10.1016/j.reprotox.2011.08.010
Xu Y, 2008, PLACENTA, V29, P962, DOI 10.1016/j.placenta.2008.08.011
Xu Y, 2006, ARCH TOXICOL, V80, P293, DOI 10.1007/s00204-005-0047-z
Xu Y, 2005, TOXICOL SCI, V84, P287, DOI 10.1093/toxsci/kfi083
Yamada J, 2010, TOXICOL LETT, V198, P282, DOI 10.1016/j.toxlet.2010.07.011
Yaoi T, 2008, BIOCHEM BIOPH RES CO, V376, P563, DOI 10.1016/j.bbrc.2008.09.028
Ye LP, 2011, TOXICOL LETT, V207, P137, DOI 10.1016/j.toxlet.2011.09.001
Yolton K, 2011, NEUROTOXICOL TERATOL, V33, P558, DOI 10.1016/j.ntt.2011.08.003
Yoshida M, 2004, J REPROD DEVELOP, V50, P349, DOI 10.1262/jrd.50.349
Yoshino S, 2004, IMMUNOLOGY, V112, P489, DOI 10.1046/j.1365-2567.2004.01900.x
Yu CJ, 2011, ENVIRON TOXICOL PHAR, V31, P88, DOI 10.1016/j.etap.2010.09.009
Zachut M, 2010, J DAIRY SCI, V93, P529, DOI 10.3168/jds.2009-2167
Zhang T, 2010, ENVIRON SCI TECHNOL, V44, P3572, DOI 10.1021/es1000159
Zhang WJ, 2011, ONCOL REP, V26, P621, DOI 10.3892/or.2011.1352
Zhang YH, 2009, J PEDIATR-US, V155, P500, DOI 10.1016/j.jpeds.2009.04.007
Zhang ZF, 2011, ENVIRON SCI TECHNOL, V45, P7044, DOI 10.1021/es200976k
Zheng L, 2011, J IMMUNOTOXICOL, V8, P30, DOI 10.3109/1547691X.2010.537287
Zhou R, 2009, NEUROSCIENCE, V159, P161, DOI 10.1016/j.neuroscience.2008.12.028
Zhou W, 2008, MOL CELL ENDOCRINOL, V283, P12, DOI 10.1016/j.mce.2007.10.010
Zuo ZH, 2011, ENVIRON TOXICOL, V26, P79, DOI 10.1002/tox.20531
NR 323
TC 15
Z9 15
PU FUTURE MEDICINE LTD
PI LONDON
PA UNITEC HOUSE, 3RD FLOOR, 2 ALBERT PLACE, FINCHLEY CENTRAL, LONDON, N3
1QB, ENGLAND
SN 1750-1911
J9 EPIGENOMICS-UK
JI Epigenomics
PD AUG
PY 2012
VL 4
IS 4
BP 383
EP 402
DI 10.2217/EPI.12.31
PG 20
WC Genetics & Heredity
SC Genetics & Heredity
GA 082NN
UT WOS:000314398800009
PM 22920179
ER
PT J
AU Cinque, C
Pondiki, S
Oddi, D
Di Certo, MG
Marinelli, S
Troisi, A
Moles, A
D'Amato, FR
AF Cinque, C.
Pondiki, S.
Oddi, D.
Di Certo, M. G.
Marinelli, S.
Troisi, A.
Moles, A.
D'Amato, F. R.
TI Modeling socially anhedonic syndromes: genetic and pharmacological
manipulation of opioid neurotransmission in mice
SO TRANSLATIONAL PSYCHIATRY
LA English
DT Article
DE affiliation; animal model; attachment behavior; naltrexone; ultrasonic
vocalizations; mu-KO mice
ID INBRED MOUSE STRAINS; RECEPTOR GENE; SEPARATION DISTRESS; ATTACHMENT
BEHAVIOR; SPECTRUM DISORDERS; ENDOGENOUS OPIOIDS; HEALTHY-VOLUNTEERS;
ODOR PREFERENCE; INFANT RATS; OPRM1
AB Social anhedonia, or the diminished capacity to experience pleasure and reward from social affiliation, is a major symptom of different psychiatric disorders, including some forms of infantile autism and schizophrenia spectrum disorders. The brain opioid hypothesis of social attachment is a promising model for achieving insights into how neurobiological and developmental factors contribute to the regulation of social reward. In this study, genetic knocking-out and naltrexone (NTRX) treatment during the first 4 days of life were used to disrupt opioid neurotransmission in mouse pups and their attachment relationships with the mother. Both permanent (genetic) and transient (pharmacological) manipulations of opioid neurotransmission exerted long-term effects on social affiliation. When juveniles, both mu-opioid receptor knockout mice and NTRX-treated pups showed reduced interest in peers and no preference for socially rewarding environment. These results demonstrate that sociability in juvenile mice is highly dependent on the establishment during infancy of a positive affective relationship with their mothers and that opioid neurotransmission has a major role in the regulation of social hedonic capacity. If the validity of this animal model will be confirmed by future research, translational studies focusing on the interaction between early experience and opioid neurotransmission could provide useful insights for identifying endophenotypes of human psychiatric disorders associated with social anhedonia. Translational Psychiatry (2012) 2, e155; doi:10.1038/tp.2012.83; published online 28 August 2012
C1 [Cinque, C.; Pondiki, S.; Oddi, D.; Di Certo, M. G.; Marinelli, S.; Moles, A.; D'Amato, F. R.] CNR, Cell Biol & Neurobiol Inst, I-00143 Rome, Italy.
[Cinque, C.; Pondiki, S.; Oddi, D.; Di Certo, M. G.; Marinelli, S.; Moles, A.; D'Amato, F. R.] IRCCS Santa Lucia Fdn, Rome, Italy.
[Troisi, A.] Univ Roma Tor Vergata, Dept Syst Med, Rome, Italy.
[Moles, A.] Genomnia, Linate, Italy.
RP D'Amato, FR (reprint author), CNR, Cell Biol & Neurobiol Inst, Via Fosso Fiorano 64-65, I-00143 Rome, Italy.
EM francesca.damato@cnr.it
FU Telethon, Italy [GGP05220]; Regione Lazio for 'Sviluppo della Ricerca
sul Cervello'
FX Thanks to Brigitte L Kieffer for comments on the manuscript, scientific
support and providing animals. This study has been granted by Telethon,
Italy (Grant no. GGP05220) and also partially supported by funds from
Regione Lazio for 'Sviluppo della Ricerca sul Cervello'.
CR Alvarez-Fuentes J, 2000, J PHARM PHARMACOL, V52, P659, DOI 10.1211/0022357001774499
Barr CS, 2008, P NATL ACAD SCI USA, V105, P5277, DOI 10.1073/pnas.0710225105
BOWLBY J, 1958, INT J PSYCHOANAL, V39, P350
Brodkin ES, 2004, BRAIN RES, V1002, P151, DOI 10.1016/j.brainres.2003.12.013
BRONSON FH, 1979, Q REV BIOL, V54, P265, DOI 10.1086/411295
Brown LH, 2007, PSYCHOL SCI, V18, P778, DOI 10.1111/j.1467-9280.2007.01978.x
Ebstein RP, 2009, ANN NY ACAD SCI, V1167, P87, DOI 10.1111/j.1749-6632.2009.04541.x
Harrop C, 2001, CLIN PSYCHOL REV, V21, P241, DOI 10.1016/S0272-7358(99)00047-1
Harvey PO, 2007, MOL PSYCHIATR, V12, P767, DOI 10.1038/sj.mp.4002021
Heinrichs M, 2008, PROG BRAIN RES, V170, P337, DOI 10.1016/S0079-6123(08)00428-7
HERMAN BH, 1978, PHARMACOL BIOCHEM BE, V9, P213, DOI 10.1016/0091-3057(78)90167-3
Higham JP, 2011, BEHAV NEUROSCI, V125, P131, DOI 10.1037/a0022695
Insel TR, 2001, NAT REV NEUROSCI, V2, P129, DOI 10.1038/35053579
Kwapil TR, 1998, J ABNORM PSYCHOL, V107, P558, DOI 10.1037//0021-843X.107.4.558
Mague SD, 2010, DRUG ALCOHOL DEPEN, V108, P172, DOI 10.1016/j.drugalcdep.2009.12.016
Matthes HWD, 1996, NATURE, V383, P819, DOI 10.1038/383819a0
Moles A, 2004, SCIENCE, V304, P1983, DOI 10.1126/science.1095943
Moy SS, 2004, GENES BRAIN BEHAV, V3, P287, DOI 10.1111/j.1601-183X.2004.00076.x
Nandhu MS, 2010, J NEUROSCI RES, V88, P3215, DOI 10.1002/jnr.22463
Nelson EE, 1998, NEUROSCI BIOBEHAV R, V22, P437, DOI 10.1016/S0149-7634(97)00052-3
OSTERMEYER MC, 1983, DEV PSYCHOBIOL, V16, P75, DOI 10.1002/dev.420160202
Panksepp J., 1985, PSYCHOBIOLOGY ATTACH, P3
PANKSEPP J, 1978, BIOL PSYCHIAT, V13, P607
Panksepp J, 1994, Acta Paediatr Suppl, V397, P40
Panksepp JB, 2007, GENES BRAIN BEHAV, V6, P661, DOI 10.1111/j.1601-183X.2006.00295.x
Pietropaolo Susanna, 2011, PLoS One, V6, pe17073, DOI 10.1371/journal.pone.0017073
Roth TL, 2006, DEV PSYCHOBIOL, V48, P71, DOI 10.1002/dev.20107
Roth TL, 2001, DEV PSYCHOBIOL, V39, P188, DOI 10.1002/dev.1044
Roth TL, 2003, PHYSIOL BEHAV, V78, P135, DOI 10.1016/S0031-9384(02)00961-7
Sankoorikal GMV, 2006, BIOL PSYCHIAT, V59, P415, DOI 10.1016/j.biopsych.2005.07.026
Scattoni ML, 2011, GENES BRAIN BEHAV, V10, P44, DOI 10.1111/j.1601-183X.2010.00623.x
Schiffman J, 2004, AM J PSYCHIAT, V161, P2021, DOI 10.1176/appi.ajp.161.11.2021
SCHINO G, 1992, BRAIN RES, V576, P125, DOI 10.1016/0006-8993(92)90617-I
Seltzer MM, 2003, J AUTISM DEV DISORD, V33, P565, DOI 10.1023/B:JADD.0000005995.02453.0b
Skuse DH, 2009, TRENDS COGN SCI, V13, P27, DOI 10.1016/j.tics.2008.09.007
Stein Dan J, 2007, CNS Spectr, V12, P669
Troisi A, 2005, BEHAV BRAIN SCI, V28, P365
Troisi A, 2010, PERS INDIV DIFFER, V48, P640, DOI 10.1016/j.paid.2010.01.002
Troisi A, 2011, SOC NEUROSCI-UK, V6, P88, DOI 10.1080/17470919.2010.482786
Troisi A, 2012, SOC COGN AFFECT NEUR, V7, P542, DOI 10.1093/scan/nsr037
Vukojevic V, 2008, FASEB J, V22, P3537, DOI 10.1096/fj.08-108894
NR 41
TC 8
Z9 8
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 2158-3188
J9 TRANSL PSYCHIAT
JI Transl. Psychiatr.
PD AUG
PY 2012
VL 2
AR e155
DI 10.1038/tp.2012.83
PG 7
WC Psychiatry
SC Psychiatry
GA 062DL
UT WOS:000312899200010
PM 22929597
ER
PT J
AU Pankhurst, MW
McLennan, IS
AF Pankhurst, M. W.
McLennan, I. S.
TI Inhibin B and anti-Mullerian hormone/Mullerian-inhibiting substance may
contribute to the male bias in autism
SO TRANSLATIONAL PSYCHIATRY
LA English
DT Article
DE boys; congential disorders; Sertoli cell hormones; sex bias; testes; TGF
beta superfamily
ID PERVASIVE DEVELOPMENTAL DISORDERS; CHROMATOGRAPHY-MASS-SPECTROMETRY;
SPECTRUM DISORDERS; RAT-BRAIN; IN-VITRO; HORMONE; ACTIVIN; SERUM;
TESTOSTERONE; RECEPTOR
AB The autistic spectrum disorders have a significant male bias in incidence, which is unexplained. The Sertoli cells of the immature testes secrete supra-adult levels of Mullerian-inhibiting/substance/antin-Mullerian hormone (AMH) and inhibin B (InhB), with both hormones being putative regulators of brain development. We report here, that 82 boys with an autism spectrum disorder have normal levels of InhB and AMH. However, the boys' level of InhB correlated with their autism diagnostic interview-revised (ADI-R) scores for the social interaction (R = 0.29, P = 0.009, N 82) and communication domains (R = 0.29, P = 0.022, N = 63), and with the number of autistic traits the boys exhibited (R = 0.34 and 0.27, respectively). The strengths of the abovementioned correlates were stronger in the boys with milder autism (R = 0.42 and 0.50, respectively), with AMH exhibiting a significant negative correlation to the ADI-R score in these boys (R = -0.44 and R = -0.39, respectively). Neither hormone correlated to the incidence of stereotyped and repetitive behaviours. This suggests that the male bias in the autistic spectrum has multiple determinants, which modulate the effects of an otherwise non-dimorphic pathology. Furthermore, AMH and InhB have opposing effects on the SMAD1/5/8 pathway, and opposing correlates to autistic traits, implicating the SMAD pathways as a putative point of molecular convergence for the autistic spectrum. Translational Psychiatry (2012) 2, e148; doi:10.1038/tp.2012.72; published online 14 August 2012
C1 [Pankhurst, M. W.; McLennan, I. S.] Univ Otago, Dept Anat, Otago Sch Med Sci, Dunedin 9054, New Zealand.
RP McLennan, IS (reprint author), Univ Otago, Dept Anat, Otago Sch Med Sci, Lindo Ferguson Bldg,Great King St,POB 913, Dunedin 9054, New Zealand.
EM ian.mclennan@otago.ac.nz
FU New Economic Research Fund grant from the Ministry of Science and
Innovation, New Zealand; National Institute of Mental Health
[1U24MH081810]
FX This study was funded by a New Economic Research Fund grant from the
Ministry of Science and Innovation, New Zealand. We thank Ms N Batchelor
and B-L Leathart for their technical assistance, and Prof. P Herbison
for his statistical advice. We gratefully acknowledge the resources
provided by the AGRE consortium and the participating AGRE families. The
AGRE is a programme of Autism Speaks and is supported, in part, by grant
1U24MH081810 from the National Institute of Mental Health to CM
Lajonchere (PI).
CR Abrahams BS, 2008, NAT REV GENET, V9, P341, DOI 10.1038/nrg2346
Aksglaede L, 2010, J CLIN ENDOCR METAB, V95, P5357, DOI 10.1210/jc.2010-1207
Allen HL, 2010, NATURE, V467, P832, DOI 10.1038/nature09410
Andersson AM, 1997, J CLIN ENDOCR METAB, V82, P3976, DOI 10.1210/jc.82.12.3976
Arnold AP, 2004, NAT REV NEUROSCI, V5, P701, DOI 10.1038/nrn1494
Baron-Cohen S, 2002, TRENDS COGN SCI, V6, P248, DOI 10.1016/S1364-6613(02)01904-6
Bergada I, 2006, J CLIN ENDOCR METAB, V91, P4092, DOI 10.1210/jc.2006-1079
Bilican B, 2008, PLOS ONE, V3, DOI 10.1371/journal.pone.0002863
CAMERON VA, 1994, ENDOCRINOLOGY, V134, P799, DOI 10.1210/en.134.2.799
Courchesne E, 2010, BRAIN RES, V1380, P138
Crofton PM, 2004, J CLIN ENDOCR METAB, V89, P867, DOI 10.1210/jc.2003-030884
David L, 2009, CYTOKINE GROWTH F R, V20, P203, DOI 10.1016/j.cytogfr.2009.05.001
de Kretser DM, 2004, MOL CELL ENDOCRINOL, V225, P57, DOI 10.1016/j.mce.2004.07.008
Dennis NA, 2012, J CLIN ENDOCR METAB, V97, P2450, DOI 10.1210/jc.2012-1213
Ebendal T, 1998, J NEUROSCI RES, V51, P139, DOI 10.1002/(SICI)1097-4547(19980115)51:2<139::AID-JNR2>3.0.CO;2-E
Fombonne E, 2003, J AUTISM DEV DISORD, V33, P365, DOI 10.1023/A:1025054610557
Geschwind DH, 2011, TRENDS COGN SCI, V15, P409, DOI 10.1016/j.tics.2011.07.003
Giedd JN, 2010, NEURON, V67, P728, DOI 10.1016/j.neuron.2010.08.040
Guibourdenche J, 2003, MOL CELL ENDOCRINOL, V211, P55, DOI 10.1016/j.mce.2003.09.011
Lee MM, 1996, J CLIN ENDOCR METAB, V81, P571, DOI 10.1210/jc.81.2.571
Levy SE, 2009, LANCET, V374, P1627, DOI 10.1016/S0140-6736(09)61376-3
Liu AM, 2005, NAT REV NEUROSCI, V6, P945, DOI 10.1038/nrn1805
LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
Lowery JW, 2010, CYTOKINE GROWTH F R, V21, P287, DOI 10.1016/j.cytogfr.2010.06.001
MacLaughlin DT, 2004, NEW ENGL J MED, V350, P367, DOI 10.1056/NEJMra022784
Morgan K, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0020533
Morgan K, 2011, BEHAV BRAIN RES, V221, P304, DOI 10.1016/j.bbr.2011.02.048
Morpurgo PS, 2004, EUR J OBSTET GYN R B, V117, P38, DOI 10.1016/j.ejogrb.2004.02.030
Newschaffer CJ, 2007, ANNU REV PUBL HEALTH, V28, P235, DOI 10.1146/annurev.publhealth.28.021406.144007
Pinto D, 2010, NATURE, V466, P368, DOI 10.1038/nature09146
Sanchez-Camacho C, 2009, BIOESSAYS, V31, P1013, DOI 10.1002/bies.200900063
Santibanez JF, 2011, CLIN SCI, V121, P233, DOI 10.1042/CS20110086
Sebat J, 2007, SCIENCE, V316, P445, DOI 10.1126/science.1138659
Shoji-Kasai Y, 2007, J CELL SCI, V120, P3830, DOI 10.1242/jcs.012450
Soderstrom S, 1996, CELL TISSUE RES, V286, P269, DOI 10.1007/s004410050697
Stipursky J, 2007, GLIA, V55, P1023, DOI 10.1002/glia.20522
TAKAGI S, 1977, J STEROID BIOCHEM, V8, P609
Wang PY, 2005, P NATL ACAD SCI USA, V102, P16421, DOI 10.1073/pnas.0508304102
Wang PY, 2009, P NATL ACAD SCI USA, V106, P7203, DOI 10.1073/pnas.0902253106
Wudy SA, 1999, J CLIN ENDOCR METAB, V84, P2724, DOI 10.1210/jc.84.8.2724
WUDY SA, 1995, PEDIATR RES, V38, P76, DOI 10.1203/00006450-199507000-00013
NR 41
TC 3
Z9 3
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 2158-3188
J9 TRANSL PSYCHIAT
JI Transl. Psychiatr.
PD AUG
PY 2012
VL 2
AR e148
DI 10.1038/tp.2012.72
PG 6
WC Psychiatry
SC Psychiatry
GA 062DL
UT WOS:000312899200003
PM 22872163
ER
PT J
AU Payakachat, N
Tilford, JM
Kovacs, E
Kuhlthau, K
AF Payakachat, Nalin
Tilford, J. Mick
Kovacs, Erica
Kuhlthau, Karen
TI Autism spectrum disorders: a review of measures for clinical, health
services and cost effectiveness applications
SO EXPERT REVIEW OF PHARMACOECONOMICS & OUTCOMES RESEARCH
LA English
DT Review
DE autism spectrum disorders; behavioral outcomes; children; clinical
outcomes; economic evaluation; HRQL; preference-weighted scores
ID QUALITY-OF-LIFE; PERVASIVE DEVELOPMENTAL DISORDERS; DIAGNOSTIC
OBSERVATION SCHEDULE; REPORTED OUTCOMES MEASUREMENT; GENERIC CORE
SCALES; CHILD HEALTH; PSYCHIATRIC-DISORDERS; REPETITIVE BEHAVIORS;
ECONOMIC EVALUATIONS; ASPERGER-SYNDROME
AB Autism spectrum disorders (ASDs) are characterized by impairments in social interaction, communication and behavioral functioning that can affect the health-related quality-of-life outcomes of the affected child and the family. ASDs have increased in prevalence, leading to a demand for improved understanding of the comparative effectiveness of different pharmacologic, behavioral, medical and alternative treatments for children as well as systems for providing services. This review describes outcome instruments that can be used for clinical, health services and cost effectiveness applications. There is a pressing need to identify the most appropriate instruments for measuring health-related quality-of-life outcomes in this population. Studies evaluating the cost effectiveness of interventions or treatments for children with ASDs using the cost per quality-adjusted life year metric are lacking. Researchers have the potential to contribute greatly to the field of autism by quantifying outcomes that can inform optimal treatment strategies.
C1 [Payakachat, Nalin; Tilford, J. Mick] Univ Arkansas Med Sci, Div Pharmaceut Evaluat & Policy, Little Rock, AR 72205 USA.
[Tilford, J. Mick] Univ Arkansas Med Sci, Dept Hlth Policy & Management, Little Rock, AR 72205 USA.
[Kovacs, Erica] Columbia Univ, Dept Psychiat, New York, NY USA.
[Kuhlthau, Karen] Harvard Univ, Sch Med, Dept Pediat, Boston, MA 02115 USA.
[Kuhlthau, Karen] Massachusetts Gen Hosp, Ctr Adolescent Hlth Policy, Boston, MA 02114 USA.
RP Payakachat, N (reprint author), Univ Arkansas Med Sci, Div Pharmaceut Evaluat & Policy, Little Rock, AR 72205 USA.
EM npayakachat@uams.edu
FU National Institute of Mental Health [R01MH089466]; NIH through the
Translational Research Institute at the University of Arkansas for
Medical Sciences [1UL1RR029884]
FX This project was supported by award number R01MH089466 from the National
Institute of Mental Health with K Kuhlthau and JM Tilford serving as
Principal Investigators. JM Tilford also received support from the NIH
(Grant # 1UL1RR029884) through the Translational Research Institute at
the University of Arkansas for Medical Sciences. The content of this
article is solely the responsibility of the authors and does not
necessarily represent the official views of the National Institute of
Mental Health or the NIH. The authors have no other relevant
affiliations or financial involvement with any organization or entity
with a financial interest in or financial conflict with the subject
matter or materials discussed in the manuscript apart from those
disclosed.
CR Achenbach T, 2000, MANUAL ASEBA PRESCHO
Achenbach T M, 2000, Pediatr Rev, V21, P265, DOI 10.1542/pir.21-8-265
Allik H, 2006, HEALTH QUAL LIFE OUT, V4, DOI 10.1186/1477-7525-4-1
Aman Michael G, 2004, Semin Pediatr Neurol, V11, P225, DOI 10.1016/j.spen.2004.07.006
AMAN MG, 1985, AM J MENT DEF, V89, P485
American Psychiatric Association, 2000, DIAGN STAT MAN MENT
American Psychiatric Association, DSM 5 FUT PSYCH DIAG
Arnold LE, 2003, J AM ACAD CHILD PSY, V42, P1443, DOI 10.1097/01.chi.0000091946.28938.54
Arnold LE, 2006, J AM ACAD CHILD PSY, V45, P1196, DOI 10.1097/01.chi.0000231976.28719.2a
Autism and Developmental Disabilities Monitoring Network Surveillance Year 2002 Principal Investigators, 2009, MMWR SURVEILL SUMM, V56, P12
Barbaresi WJ, 2006, ARCH PEDIAT ADOL MED, V160, P1167, DOI 10.1001/archpedi.160.11.1167
Barbaresi WJ, 2005, ARCH PEDIAT ADOL MED, V159, P37, DOI 10.1001/archpedi.159.1.37
Baron-Cohen S., 2001, PRISME, V34, P174
Basu A, 2005, J HEALTH ECON, V24, P751, DOI 10.1016/j.jhealco.2004.12.002
Basu A, 2007, HEALTH ECON, V16, P1133, DOI 10.1002/hec.1291
Basu A, 2010, MED DECIS MAKING, V30, P355, DOI 10.1177/0272989X09349959
Basu A, 2011, J HEALTH ECON, V30, P549, DOI 10.1016/j.jhealeco.2011.03.004
Bayley N., 2005, BAYLEY SCALES INFANT, Vthird
Belsito KM, 2001, J AUTISM DEV DISORD, V31, P175, DOI 10.1023/A:1010799115457
Bertrand J, 2001, PEDIATRICS, V108, P1155, DOI 10.1542/peds.108.5.1155
Bevans KB, 2010, EXPERT REV PHARM OUT, V10, P385, DOI [10.1586/erp.10.52, 10.1586/ERP.10.52]
Bobinac A, 2010, J HEALTH ECON, V29, P549, DOI 10.1016/j.jhealeco.2010.05.003
Bobinac A, 2011, MED DECIS MAKING, V31, P292, DOI 10.1177/0272989X10374212
Bodfish JW, 2000, J AUTISM DEV DISORD, V30, P237, DOI 10.1023/A:1005596502855
Brouwer W., 2009, EC EVALUATION CHILD, P55
Brouwer WBF, 2006, QUAL LIFE RES, V15, P1005, DOI 10.1007/s11136-005-5994-6
Brouwer WBF, 1999, INT J TECHNOL ASSESS, V15, P147, DOI 10.1017/S0266462399152346
Canitano R, 2011, PROG NEURO-PSYCHOPH, V35, P18, DOI 10.1016/j.pnpbp.2010.10.015
Carter AS, 1998, J AUTISM DEV DISORD, V28, P287, DOI 10.1023/A:1026056518470
Chasson G. S., 2007, J CHILD FAM STUD, V16, P401, DOI DOI 10.1007/S10826-006-9094-1
Constantino JN, 2003, J AUTISM DEV DISORD, V33, P427, DOI 10.1023/A:1025014929212
Constantino JN, 2002, SOCIAL RESPONSIVENES
Constantino JN, 2000, AM J PSYCHIAT, V157, P2043, DOI 10.1176/appi.ajp.157.12.2043
Coplan J, 2005, PEDIATRICS, V116, P117, DOI 10.1542/peds.2004-1118
Coplan J, 2003, DEV MED CHILD NEUROL, V45, P712, DOI 10.1017/S0012162203001324
Couturier JL, 2005, J AM ACAD CHILD PSY, V44, P815, DOI 10.1097/01.chi.0000166377.22651.87
Dawson G, 2010, PEDIATRICS, V125, pE17, DOI 10.1542/peds.2009-0958
Dawson G, 2008, DEV PSYCHOPATHOL, V20, P775, DOI 10.1017/S0954579408000370
Fombonne E, 2003, INT REV PSYCHIATR, V15, P158, DOI 10.1080/0954026021000046119
Gabriels RL, 2005, RES DEV DISABIL, V26, P169, DOI 10.1016/j.ridd.2004.05.003
Gold MR, 1996, COST EFFECTIVENESS H, P82
Gotham K, 2009, J AUTISM DEV DISORD, V39, P693, DOI 10.1007/s10803-008-0674-3
Gotham K, 2007, J AUTISM DEV DISORD, V37, P613, DOI 10.1007/s10803-006-0280-1
Green J, 2010, LANCET, V375, P2152, DOI 10.1016/S0140-6736(10)60587-9
Griebsch I, 2005, PEDIATRICS, V115, pE600, DOI 10.1542/peds.2004-2127
Grosse SD, 2010, EXPERT REV PHARM OUT, V10, P293, DOI [10.1586/erp.10.24, 10.1586/ERP.10.24]
Hawthorne G, 2009, VALUE HEALTH, V12, P948, DOI 10.1111/j.1524-4733.2009.00526.x
Horsman John, 2003, Health Qual Life Outcomes, V1, P54, DOI 10.1186/1477-7525-1-54
Howlin P, 2004, J CHILD PSYCHOL PSYC, V45, P212, DOI 10.1111/j.1469-7610.2004.00215.x
Interagency Autism Coordinating Committee, 2011 IACC STRAT PLAN
Johns Hopkins University, CHILD HLTH ILLN PROF
Jones HP, 2002, ARCH DIS CHILD, V86, P15, DOI 10.1136/adc.86.1.15
Kamp-Becker I, 2011, Z KINDER JUG-PSYCH, V39, P123, DOI 10.1024/1422-4917/a000098
Kim YS, 2011, AM J PSYCHIAT, V168, P904, DOI 10.1176/appi.ajp.2011.10101532
Knapp M, 2009, AUTISM, V13, P317, DOI 10.1177/1362361309104246
Kuhlthau K, 2010, J AUTISM DEV DISORD, V40, P721, DOI 10.1007/s10803-009-0921-2
Kuhlthau KA, 2011, INT SOC QUAL LIF RES
Landgraf J. M., 1996, CHQ USERS MANUAL
Limbers CA, 2009, J AUTISM DEV DISORD, V39, P1529, DOI 10.1007/s10803-009-0777-5
Limbers CA, 2011, VALUE HEALTH, V14, P521, DOI 10.1016/j.jval.2010.10.031
Limoges E, 2005, BRAIN, V128, P1049, DOI 10.1093/brain/awh425
Lord C, 2010, SOCIAL POLICY REPORT, V24, P1
LORD C, 1989, J AUTISM DEV DISORD, V19, P185, DOI 10.1007/BF02211841
LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
Lord C, 2012, ARCH GEN PSYCHIAT, V69, P306, DOI 10.1001/archgenpsychiatry.2011.148
LOVAAS OI, 1987, J CONSULT CLIN PSYCH, V55, P3, DOI 10.1037/0022-006X.55.1.3
Luby J, 2006, J CHILD ADOL PSYCHOP, V16, P575, DOI 10.1089/cap.2006.16.575
Mayes SD, 2003, AUTISM, V7, P65, DOI 10.1177/1362361303007001006
McDougle CJ, 2005, AM J PSYCHIAT, V162, P1142, DOI 10.1176/appi.ajp.162.6.1142
Militerni R, 2002, EUR CHILD ADOLES PSY, V11, P210, DOI 10.1007/s00787-002-0279-x
Moodie M, 2010, VALUE HEALTH, V13, P1014, DOI 10.1111/j.1524-4733.2010.00780.x
Mugno D, 2007, HEALTH QUAL LIFE OUT, V5, DOI 10.1186/1477-7525-5-22
Mullen E, 1995, MULLEN SCALES EARLY
Nagaraj R, 2006, J CHILD NEUROL, V21, P450, DOI 10.2310/7010.2006.00099
National Institutes of Health (NIH), PAT REP OUTC MEAS IN
Neumann PJ, 2000, ANNU REV PUBL HEALTH, V21, P587, DOI 10.1146/annurev.publhealth.21.1.587
Newschaffer CJ, 2005, PEDIATRICS, V115, pE277, DOI 10.1542/peds.2004-1958
Nixon Speechley K., 1999, INT J CANCER S, V12, P95
Oyane NMF, 2005, AUTISM, V9, P83, DOI 10.1177/1362361305049031
Payakachat N, 2011, QUAL LIFE RES, V20, P1487, DOI 10.1007/s11136-011-9870-2
Petrou S, 2010, BRIT J PSYCHIAT, V197, P395, DOI 10.1192/bjp.bp.110.081307
Petrou S, 2009, MED DECIS MAKING, V29, P291, DOI 10.1177/0272989X08327398
Petrou S, 2003, HEALTH ECON, V12, P697, DOI 10.1002/hec.775
Polimeni MA, 2005, J INTELL DISABIL RES, V49, P260, DOI 10.1111/j.1365-2788.2005.00642.x
Prosser LA, 2004, PEDIATRICS, V113, P283, DOI 10.1542/peds.113.2.283
Prosser Lisa A, 2005, Health Qual Life Outcomes, V3, P18, DOI 10.1186/1477-7525-3-18
Prosser LA, 2007, PHARMACOECONOMICS, V25, P713, DOI 10.2165/00019053-200725090-00001
Raat H, 2005, J EPIDEMIOL COMMUN H, V59, P75, DOI 10.1136/jech.2003.012614
Raat H, 2002, QUAL LIFE RES, V11, P575, DOI 10.1023/A:1016393311799
Ravens-Sieberer U, 2010, QUAL LIFE RES, V19, P887, DOI 10.1007/s11136-010-9649-x
Ravens-Sieberer U, 2007, QUAL LIFE RES, V16, P1347, DOI 10.1007/s11136-007-9240-2
Reeve BB, 2007, MED CARE, V45, pS22, DOI 10.1097/01.mlr.0000250483.85507.04
McCracken JT, 2002, NEW ENGL J MED, V347, P314, DOI 10.1056/NEJMoa013171
Riley AW, 1998, MED CARE, V36, P1237, DOI 10.1097/00005650-199808000-00011
Riley AW, 2004, MED CARE, V42, P221, DOI 10.1097/01.mlr.0000114910.46921.73
Roid GH, 2003, STANDFORD BINET INTE, VFifth
ROSENBAUM PR, 1983, BIOMETRIKA, V70, P41, DOI 10.1093/biomet/70.1.41
Rutter M., 2003, ADI R AUTISM DIAGNOS
Rutter ML, 2011, J AUTISM DEV DISORD, V41, P395, DOI 10.1007/s10803-011-1184-2
Saulnier C., 2011, TXB AUTISM SPECTRUM, P25
Schopler E., 2010, CHILDHOOD AUTISM RAT, VSecond
Schulz R, 2004, JAMA-J AM MED ASSOC, V292, P961, DOI 10.1001/jama.292.8.961
Schulz R, 2001, JAMA-J AM MED ASSOC, V285, P3123, DOI 10.1001/jama.285.24.3123
Seiber W. J., 2008, QUALITY WELL BEING S
Sheldrick RC, 2012, QUAL LIFE RES, V21, P53, DOI 10.1007/s11136-011-9916-5
Shipman DL, 2011, J DEV BEHAV PEDIATR, V32, P85, DOI 10.1097/DBP.0b013e318203e558
Smith-Olinde L, 2008, QUAL LIFE RES, V17, P943, DOI 10.1007/s11136-008-9358-x
Sparrow SS, 2005, VINELAND 2 ADAPTIVE
STEIN REK, 1990, MED CARE, V28, P1041, DOI 10.1097/00005650-199011000-00006
Stevens K., 2010, VALUATION CHILD HLTH
Stevens K, 2009, QUAL LIFE RES, V18, P1105, DOI 10.1007/s11136-009-9524-9
Strock M, 2004, NIH045511 NIHMD US D
Tadevosyan-Leyfer O, 2003, J AM ACAD CHILD PSY, V42, P864, DOI 10.1097/01.CHI.0000046870.56865.90
Tilford JM, 2002, AMBUL PEDIATR, V2, P330, DOI 10.1367/1539-4409(2002)002<0330:CEAAEM>2.0.CO;2
Tilford JM, 2012, PHARMACOECO IN PRESS
Toth K, 2008, AM J PSYCHIAT, V165, P958, DOI 10.1176/appi.ajp.2008.08020272
Ungar W.J., 2009, EC EVALUATION CHILD
Varni JW, 2001, MED CARE, V39, P800, DOI 10.1097/00005650-200108000-00006
Varni JW, 2003, AMBUL PEDIATR, V3, P329, DOI 10.1367/1539-4409(2003)003<0329:TPAAPP>2.0.CO;2
Volkmar F. R., 2005, HDB AUTISM PERVASIVE
Wang L, 2010, J AM ACAD CHILD PSY, V49, P1165, DOI 10.1016/j.jaac.2010.08.003
Warren Z., 2011, COMP EFFECTIVENESS R, V26
Wechsler D., 2003, WECHSLER INTELLIGENC
Weinstein MC, 1996, JAMA-J AM MED ASSOC, V276, P1253, DOI 10.1001/jama.276.15.1253
West L, 2009, J PEDIATR HEALTH CAR, V23, P75, DOI 10.1016/j.pedhc.2008.12.001
Wille N, 2010, QUAL LIFE RES, V19, P875, DOI 10.1007/s11136-010-9648-y
Willems DCM, 2009, INT J TECHNOL ASSESS, V25, P391, DOI 10.1017/S0266462309990171
Wing L, 2002, MENT RETARD DEV D R, V8, P151, DOI 10.1002/mrdd.10029
Yeargin-Allsopp M, 2003, JAMA-J AM MED ASSOC, V289, P49, DOI 10.1001/jama.289.1.49
NR 130
TC 3
Z9 3
PU EXPERT REVIEWS
PI LONDON
PA UNITEC HOUSE, 3RD FL, 2 ALBERT PLACE, FINCHLEY CENTRAL, LONDON N3 1QB,
ENGLAND
SN 1473-7167
J9 EXPERT REV PHARM OUT
JI Expert Rev. Pharmacoecon. Outcomes Res.
PD AUG
PY 2012
VL 12
IS 4
BP 485
EP 503
DI 10.1586/ERP.12.29
PG 19
WC Health Care Sciences & Services; Health Policy & Services; Pharmacology
& Pharmacy
SC Health Care Sciences & Services; Pharmacology & Pharmacy
GA 030GO
UT WOS:000310559200018
PM 22971035
ER
PT J
AU Rana, SA
Aavani, T
Pittman, QJ
AF Rana, Shadna A.
Aavani, Tooka
Pittman, Quentin J.
TI Sex effects on neurodevelopmental outcomes of innate immune activation
during prenatal and neonatal life
SO HORMONES AND BEHAVIOR
LA English
DT Review
DE Innate immune activation; Sex steroids; LPS; Poly(I:C); Development
ID CORTICOTROPIN-RELEASING HORMONE; PITUITARY-ADRENAL AXIS;
CENTRAL-NERVOUS-SYSTEM; LONG-TERM ALTERATIONS; TOLL-LIKE RECEPTORS;
ADULT-RAT BRAIN; ENDOTOXIN EXPOSURE; NEUROIMMUNE RESPONSES; PREPULSE
INHIBITION; FETAL-BRAIN
AB This article is part of a Special Issue "Neuroendocrine-Immune Axis in Health and Disease."
Humans are exposed to potentially harmful agents (bacteria, viruses, toxins) throughout our lifespan; the consequences of such exposure can alter central nervous system development. Exposure to immunogens during pregnancy increases the risk of developing neurological disorders such as schizophrenia and autism. Further, sex hormones, such as estrogen, have strong modulatory effects on immune function and have also been implicated in the development of neuropathologies (e.g.. schizophrenia and depression). Similarly, animal studies have demonstrated that immunogen exposure in utero or during the neonatal period, at a time when the brain is undergoing maturation, can induce changes in learning and memory, as well as dopamine-mediated behaviors in a sex-specific manner. Literature that covers the effects of immunogens on innate immune activation and ultimately the development of the adult brain and behavior is riddled with contradictory findings, and the addition of sex as a factor only adds to the complexity. This review provides evidence that innate immune activation during critical periods of development may have effects on the adult brain in a sex-specific manner. Issues regarding sex bias in research as well as variability in animal models of immune function are discussed. (C) 2012 Elsevier Inc. All rights reserved.
C1 [Rana, Shadna A.; Aavani, Tooka; Pittman, Quentin J.] Univ Calgary, Fac Med, Dept Physiol & Pharmacol, Hotchkiss Brain Inst,Hlth Sci Ctr, Calgary, AB T2N 4N1, Canada.
RP Pittman, QJ (reprint author), Univ Calgary, Fac Med, Dept Physiol & Pharmacol, Hotchkiss Brain Inst,Hlth Sci Ctr, 3330 Hosp Dr NW, Calgary, AB T2N 4N1, Canada.
EM pittman@ucalgary.ca
FU Canadian Institutes of Health Research; Alberta Heritage Foundation for
Medical Research (AHFMR); Hotchkiss Brain Institute-AHFMR Provincial
Program on Perinatal Determinants of Brain and Mental Health
FX This work was supported by the Canadian Institutes of Health Research
and by personnel support grants to SAR and QJP from Alberta Heritage
Foundation for Medical Research (AHFMR) and to TA from the Hotchkiss
Brain Institute-AHFMR Provincial Program on Perinatal Determinants of
Brain and Mental Health.
CR Aleman A, 2003, ARCH GEN PSYCHIAT, V60, P565, DOI 10.1001/archpsyc.60.6.565
Angermeyer MC, 1998, INT J SOC PSYCHIATR, V44, P107, DOI 10.1177/002076409804400203
Ashdown H, 2006, MOL PSYCHIATR, V11, P47, DOI 10.1038/sj.mp.4001748
BAYER SA, 1995, EXP BRAIN RES, V105, P191
Beery AK, 2011, NEUROSCI BIOBEHAV R, V35, P565, DOI 10.1016/j.neubiorev.2010.07.002
Bell MJ, 2004, PEDIATR RES, V56, P541, DOI 10.1203/01.PDR.0000139407.89883.6B
Bilbo SD, 2006, BEHAV BRAIN RES, V169, P39, DOI 10.1016/j.bbr.2005.12.002
Bilbo SD, 2010, PSYCHONEUROENDOCRINO, V35, P369, DOI 10.1016/j.psyneuen.2009.07.014
Bilbo SD, 2005, BEHAV NEUROSCI, V119, P293, DOI 10.1037/0735-7044.119.1.293
BINGAMAN EW, 1994, NEUROENDOCRINOLOGY, V59, P228, DOI 10.1159/000126663
Bitanihirwe BKY, 2010, NEUROPSYCHOPHARMACOL, V35, P2462, DOI 10.1038/npp.2010.129
Boisse L, 2004, J NEUROSCI, V24, P4928, DOI 10.1523/JNEUROSCI.1077-04.2004
Boksa P, 2010, BRAIN BEHAV IMMUN, V24, P881, DOI 10.1016/j.bbi.2010.03.005
Borrell J, 2002, NEUROPSYCHOPHARMACOL, V26, P204, DOI 10.1016/S0893-133X(01)00360-8
BORTOLUSSI R, 1992, PEDIATR RES, V32, P460, DOI 10.1203/00006450-199210000-00017
Boulanger LM, 2009, NEURON, V64, P93, DOI 10.1016/j.neuron.2009.09.001
Broersen LM, 2000, PROG BRAIN RES, V126, P79
Brown AS, 2004, ARCH GEN PSYCHIAT, V61, P774, DOI 10.1001/archpsyc.61.8.774
Bsibsi M, 2002, J NEUROPATH EXP NEUR, V61, P1013
Cai ZW, 2000, PEDIATR RES, V47, P64, DOI 10.1203/00006450-200001000-00013
Carpentier P. A, 2009, AM J PATHOL, V178, P2802
Chrousos GP, 2010, SCI SIGNAL, V3, DOI 10.1126/scisignal.3143pe36
Deutsch SI, 2010, EUR NEUROPSYCHOPHARM, V20, P281, DOI 10.1016/j.euroneuro.2010.02.005
Dobrovolskaia MA, 2003, J IMMUNOL, V170, P508
DOUKAS J, 1994, AM J PATHOL, V145, P137
Doyle SL, 2006, BIOCHEM PHARMACOL, V72, P1102, DOI 10.1016/j.bcp.2006.07.010
DUNN AJ, 1988, LIFE SCI, V43, P429, DOI 10.1016/0024-3205(88)90522-X
Ellis S, 2005, FASEB J, V19, P1519, DOI 10.1096/fj.04-3569fje
Ellis S, 2006, J PHYSIOL-LONDON, V571, P695, DOI 10.1113/jphysiol.2005.102939
Escobar M, 2011, BIOL PSYCHIAT, V70, P992, DOI 10.1016/j.biopsych.2011.01.009
Fan LW, 2011, BRAIN BEHAV IMMUN, V25, P286, DOI 10.1016/j.bbi.2010.09.020
Fatemi SH, 2009, SCHIZOPHRENIA BULL, V35, P528, DOI 10.1093/schbul/sbn187
Fatemi SH, 2002, CELL MOL NEUROBIOL, V22, P25, DOI 10.1023/A:1015337611258
FLORHENRY P, 1990, SCHIZOPHRENIA BULL, V16, P211
Foster JA, 2008, INTERDISCIP PERSPECT, V2008, DOI DOI 10.1155/2008/839501
Fourgeaud L, 2010, EUR J NEUROSCI, V32, P207, DOI 10.1111/j.1460-9568.2010.07342.x
Gaillard RC, 1998, DOMEST ANIM ENDOCRIN, V15, P345, DOI 10.1016/S0739-7240(98)00028-9
Galic MA, 2012, FRONT NEUROENDOCRIN, V33, P116, DOI 10.1016/j.yfrne.2011.12.002
Galic MA, 2009, INTEGR COMP BIOL, V49, P237, DOI 10.1093/icb/icp025
Garnier Y, 2003, J SOC GYNECOL INVEST, V10, P450, DOI 10.1016/S1071-5576(03)00150-3
Gayle DA, 2004, AM J PHYSIOL-REG I, V286, pR1024, DOI 10.1152/ajpregu.00664.2003
Gilmore JH, 2005, J NEUROIMMUNOL, V159, P106, DOI 10.1016/j.jneuroim.2004.10.008
Golan H, 2006, NEUROSCIENCE, V141, P1909, DOI 10.1016/j.neuroscience.2006.05.045
Golan HM, 2005, NEUROPHARMACOLOGY, V48, P903, DOI 10.1016/j.neuropharm.2004.12.023
GROSSMAN CJ, 1984, ENDOCR REV, V5, P435
Gue M, 2004, BEHAV BRAIN RES, V150, P149, DOI 10.1016/S0166-4328(03)00250-X
HAFNER H, 1993, PSYCHOL MED, V23, P925
Harre EM, 2008, EUR J NEUROSCI, V27, P644, DOI 10.1111/j.1460-9568.2008.06031.x
Heinrich PC, 1998, BIOCHEM J, V334, P297
Hodyl NA, 2007, J NEUROIMMUNOL, V190, P61, DOI 10.1016/j.jneuroim.2007.07.021
Hodyl NA, 2008, J NEUROIMMUNOL, V204, P126, DOI 10.1016/j.jneuroim.2008.06.041
Hornig M, 1999, P NATL ACAD SCI USA, V96, P12102, DOI 10.1073/pnas.96.21.12102
Howland JG, 2012, NEUROSCIENCE, V201, P184, DOI 10.1016/j.neuroscience.2011.11.011
Hsiao EY, 2011, BRAIN BEHAV IMMUN, V25, P604, DOI 10.1016/j.bbi.2010.12.017
Huleihel Mahmoud, 2004, Reprod Biol Endocrinol, V2, P17, DOI 10.1186/1477-7827-2-17
Ibi D, 2009, NEUROSCI RES, V64, P297, DOI 10.1016/j.neures.2009.03.015
IMHOF JT, 1993, BEHAV BRAIN RES, V56, P177, DOI 10.1016/0166-4328(93)90036-P
Iwasaki A, 2004, NAT IMMUNOL, V5, P987, DOI 10.1038/ni1112
Katafuchi T, 2003, NEUROSCIENCE, V120, P837, DOI 10.1016/S0306-4522(03)00365-8
Kentner AC, 2010, ENDOCRINOLOGY, V151, P2689, DOI 10.1210/en.2009-1101
Kline L, 1998, PSYCHOPHARMACOLOGY, V139, P322, DOI 10.1007/s002130050723
Koch M, 1998, PHYSIOL BEHAV, V64, P625, DOI 10.1016/S0031-9384(98)00098-5
Kohman RA, 2008, BEHAV BRAIN RES, V193, P257, DOI 10.1016/j.bbr.2008.06.004
Kohman RA, 2007, BRAIN BEHAV IMMUN, V21, P824, DOI 10.1016/j.bbi.2007.01.009
Kohman RA, 2008, BEHAV BRAIN RES, V194, P25, DOI 10.1016/j.bbr.2008.06.018
Lante F, 2007, FREE RADICAL BIO MED, V42, P1231, DOI 10.1016/j.freeradbiomed.2007.01.027
Laviola G, 2004, EUR J NEUROSCI, V20, P1655, DOI 10.1111/j.1460-9568.2004.03597.x
Levine S, 2001, PHYSIOL BEHAV, V73, P255, DOI 10.1016/S0031-9384(01)00496-6
Ling ZD, 2004, EXP NEUROL, V190, P373, DOI 10.1016/j.expneurol.2004.08.006
MACHON RA, 1995, NATO ADV SCI INST SE, V275, P191
MASUR J, 1980, DEV PSYCHOBIOL, V13, P107, DOI 10.1002/dev.420130202
MEDNICK SA, 1988, ARCH GEN PSYCHIAT, V45, P189
Meyer U, 2005, NEUROSCI BIOBEHAV R, V29, P913, DOI 10.1016/j.neubiorev.2004.10.012
Meyer U, 2008, NEUROPSYCHOPHARMACOL, V33, P441, DOI 10.1038/sj.npp.1301413
Meyer U, 2007, NEUROSCIENTIST, V13, P241, DOI 10.1177/1073858406296401
Meyer U, 2008, BRAIN BEHAV IMMUN, V22, P469, DOI 10.1016/j.bbi.2007.09.012
Meyer U, 2006, BRAIN BEHAV IMMUN, V20, P378, DOI 10.1016/j.bbi.2005.11.003
Meyer U, 2006, J NEUROSCI, V26, P4752, DOI 10.1523/JNEUROSCI.0099-06.2006
Meyer U, 2009, NEUROSCI BIOBEHAV R, V33, P1061, DOI 10.1016/j.neubiorev.2009.05.001
Miller MT, 2005, INT J DEV NEUROSCI, V23, P201, DOI 10.1016/j.ijdevneu.2004.06.007
MOSER E, 1993, J NEUROSCI, V13, P3916
Mouihate A, 2008, J NEUROENDOCRINOL, V20, P508, DOI 10.1111/j.1365-2826.2008.01666.x
Mouihate A, 2010, J NEUROSCI, V30, P7975, DOI 10.1523/JNEUROSCI.6078-09.2010
Mueller BR, 2007, PHYSIOL BEHAV, V91, P55, DOI 10.1016/j.physbeh.2007.01.017
Mueller BR, 2008, J NEUROSCI, V28, P9055, DOI 10.1523/JNEUROSCI.1424-08.2008
Munoz-Cruz S, 2011, CURR TOP MED CHEM, V11, P1714
Nelson Karin B., 2000, Current Opinion in Neurology, V13, P133, DOI 10.1097/00019052-200004000-00004
Nelson RJ, 1997, FRONT NEUROENDOCRIN, V18, P463, DOI 10.1006/frne.1997.0156
OCALLAGHAN E, 1994, BRIT J PSYCHIAT, V165, P353, DOI 10.1192/bjp.165.3.353
Oh-Nishi A, 2010, BRAIN RES, V1363, P170, DOI 10.1016/j.brainres.2010.09.054
Piontkewitz Y, 2011, BIOL PSYCHIAT, V70, P842, DOI 10.1016/j.biopsych.2011.06.007
Pittman D. Q. J., 2011, J NEUROENDOCRINOL, V23, P1296, DOI 10.1111/j.1365-2826.2011.02176.x
Pugh CR, 1998, BRAIN BEHAV IMMUN, V12, P212, DOI 10.1006/brbi.1998.0524
Rantakallio P, 1997, INT J EPIDEMIOL, V26, P837, DOI 10.1093/ije/26.4.837
Rodier PM, 1998, MENT RETARD DEV D R, V4, P121, DOI 10.1002/(SICI)1098-2779(1998)4:2<121::AID-MRDD9>3.0.CO;2-S
Romero E, 2010, MOL PSYCHIATR, V15, P372, DOI 10.1038/mp.2008.44
Safieh-Garabedian B, 2002, NEUROPHARMACOLOGY, V42, P864, DOI 10.1016/S0028-3908(02)00028-X
Saia RS, 2011, ACTA PHYSIOL, V203, P429, DOI 10.1111/j.1748-1716.2011.02334.x
Samuelsson AM, 2006, AM J PHYSIOL-REG I, V290, pR1345, DOI 10.1152/ajpregu.00268.2005
Schwarz JM, 2011, NEUROSCI LETT, V497, P110, DOI 10.1016/j.neulet.2011.04.042
Schwarz JM, 2012, J NEUROCHEM, V120, P948, DOI 10.1111/j.1471-4159.2011.07630.x
Schwendener S, 2009, J NEURODEV DISORD, V1, P15, DOI 10.1007/s11689-008-9000-9
SHANKS N, 1995, J NEUROSCI, V15, P376
Shanks N, 2000, P NATL ACAD SCI USA, V97, P5645, DOI 10.1073/pnas.090571897
Sharma A, 2002, NEUROBIOL DIS, V11, P246, DOI 10.1006/nbdi.2002.0531
Shaw KN, 2001, BEHAV BRAIN RES, V124, P47, DOI 10.1016/S0166-4328(01)00232-7
Shi LM, 2003, J NEUROSCI, V23, P297
Smith SEP, 2007, J NEUROSCI, V27, P10695, DOI 10.1523/JNEUROSCI.2178-07.2007
Sparkman NL, 2005, PHYSIOL BEHAV, V86, P244, DOI 10.1016/j.physbeh.2005.07.016
Spencer SJ, 2006, BRAIN BEHAV IMMUN, V20, P325, DOI 10.1016/j.bbi.2005.08.004
Spencer SJ, 2008, J PHYSIOL-LONDON, V586, P399, DOI 10.1113/jphysiol.2007.144006
Spencer SJ, 2005, BEHAV BRAIN RES, V164, P231, DOI 10.1016/j.bbr.2005.06.032
Spencer SJ, 2010, J NEUROENDOCRINOL, V22, P272, DOI 10.1111/j.1365-2826.2010.01967.x
SPINEDI E, 1992, ENDOCRINOLOGY, V131, P2430, DOI 10.1210/en.131.5.2430
Spinedi E., 2004, NEUROENDOCRINE IMMUN, P303
Susser ES, 2000, SCHIZOPHRENIA BULL, V26, P257
Swerdlow NR, 1998, SCHIZOPHRENIA BULL, V24, P285
TOTH FD, 1990, J REPROD IMMUNOL, V17, P217, DOI 10.1016/0165-0378(90)90004-P
Urakubo A, 2001, SCHIZOPHR RES, V47, P27, DOI 10.1016/S0920-9964(00)00032-3
VAMVAKOPOULOS NC, 1993, J CLIN INVEST, V92, P1896, DOI 10.1172/JCI116782
Van den Buuse M, 2001, EUR J PHARMACOL, V425, P33, DOI 10.1016/S0014-2999(01)01139-6
Voss T, 2007, CELL TISSUE RES, V328, P549, DOI 10.1007/s00441-007-0386-6
Voss T, 2006, ACTA PHYSIOL, V187, P379, DOI 10.1111/j.1748-1716.2006.01587.x
Vuillermot S, 2012, J NEUROSCI, V32, P436, DOI 10.1523/JNEUROSCI.4831-11.2012
Wagner RD, 2008, ADV EXP MED BIOL, V635, P41, DOI 10.1007/978-0-387-09550-9_4
Wald C, 2010, SCIENCE, V327, P1571, DOI 10.1126/science.327.5973.1571
Walker AK, 2009, PSYCHONEUROENDOCRINO, V34, P1515, DOI 10.1016/j.psyneuen.2009.05.010
Walker FR, 2004, BEHAV BRAIN RES, V154, P63, DOI 10.1016/j.bbr.2004.01.019
Walker FR, 2006, PHYSIOL BEHAV, V87, P126, DOI 10.1016/j.physbeh.2005.09.008
Wang H, 2010, TOXICOL LETT, V192, P245, DOI 10.1016/j.toxlet.2009.10.030
Weinstock M, 2007, NEUROCHEM RES, V32, P1730, DOI 10.1007/s11064-007-9339-4
Winter C, 2009, INT J NEUROPSYCHOPH, V12, P513, DOI 10.1017/S1461145708009206
Zhang Y., 2011, NEUROPHARMACOLOGY, V62, P1299
Zhu ZL, 2004, J NEUROSCI RES, V78, P837, DOI 10.1002/jnr.20338
Zuckerman L, 2003, NEUROPSYCHOPHARMACOL, V28, P1778, DOI 10.1038/sj.npp.1300248
NR 135
TC 9
Z9 9
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0018-506X
J9 HORM BEHAV
JI Horm. Behav.
PD AUG
PY 2012
VL 62
IS 3
BP 228
EP 236
DI 10.1016/j.yhbeh.2012.03.015
PG 9
WC Behavioral Sciences; Endocrinology & Metabolism
SC Behavioral Sciences; Endocrinology & Metabolism
GA 022GR
UT WOS:000309946300006
PM 22516179
ER
PT J
AU Schwarz, JM
Bilbo, SD
AF Schwarz, Jaclyn M.
Bilbo, Staci D.
TI Sex, glia, and development: Interactions in health and disease
SO HORMONES AND BEHAVIOR
LA English
DT Review
DE Microglia; Astrocytes; Hippocampus; Amygdala; Hypothalamus; Mental
health; Sex
ID EARLY-LIFE INFECTION; CORTICOTROPIN-RELEASING HORMONE; MICROGLIAL CELL
ACTIVATION; ESTROGEN-RECEPTOR-BETA; NECROSIS-FACTOR-ALPHA; NEURAL
STEM-CELLS; IMMUNE-RESPONSES; ASTROCYTE DIFFERENTIATION;
AUTOIMMUNE-DISEASES; SICKNESS BEHAVIOR
AB This article is part of a Special Issue "Neuroendocrine-Immune Axis in Health and Disease."
Microglia and astrocytes are the primary immune cells within the central nervous system. Microglia influence processes including neural development, synaptic plasticity and cognition; while their activation and production of immune molecules can induce stereotyped sickness behaviors or pathologies including cognitive dysfunction. Given their role in health and disease, we propose that glia may also be a critical link in understanding the etiology of many neuropsychiatric disorders that present with a strong sex-bias in their symptoms or prevalence. Specifically, males are more likely to be diagnosed with disorders that have distinct developmental origins such as autism or schizophrenia. In contrast, females are more likely to be diagnosed with disorders that present later in life, after the onset of adolescence, such as depression and anxiety disorders. In this review we will summarize the evidence suggesting that sex differences in the colonization and function of glia within the normal developing brain may contribute to distinct windows of vulnerability between males and females. We will also highlight the current gaps in our knowledge as well as the future directions and considerations of research aimed at understanding the link between neuroimmune function and sex differences in mental health disorders. (C) 2012 Elsevier Inc. All rights reserved.
C1 [Schwarz, Jaclyn M.; Bilbo, Staci D.] Duke Univ, Dept Psychol & Neurosci, Durham, NC 27705 USA.
RP Schwarz, JM (reprint author), Duke Univ, Dept Psychol & Neurosci, 572 Res Dr Rm 3017, Durham, NC 27705 USA.
EM jaclyn.schwarz@duke.edu
CR Abazyan B, 2010, BIOL PSYCHIAT, V68, P1172, DOI 10.1016/j.biopsych.2010.09.022
Amateau SK, 2002, J NEUROSCI, V22, P8586
Amateau SK, 2004, NAT NEUROSCI, V7, P643, DOI 10.1038/nn1254
Amstadter AB, 2011, DIS MARKERS, V30, P89, DOI 10.3233/DMA-2011-0761
Araque A, 2010, PHILOS T R SOC B, V365, P2375, DOI 10.1098/rstb.2009.0313
Ashwell K, 1990, Brain Res Dev Brain Res, V55, P219
Ashwell K, 1991, Brain Res Dev Brain Res, V58, P1
Ashwood P, 2010, BRAIN BEHAV IMMUN, V25, P840
Ashwood P, 2011, J NEUROIMMUNOL, V232, P196, DOI 10.1016/j.jneuroim.2010.10.025
Baker AE, 2004, ENDOCRINOLOGY, V145, P5021, DOI 10.1210/en.2004-0619
Bao AM, 2010, NEUROSCIENTIST, V16, P550, DOI 10.1177/1073858410377005
BERKENBOSCH F, 1987, SCIENCE, V238, P524, DOI 10.1126/science.2443979
Berletch JB, 2011, HUM GENET, V130, P237, DOI 10.1007/s00439-011-1011-z
BERNARDINI R, 1990, ENDOCRINOLOGY, V126, P2876
Bilbo S. D., 2011, J NEUROIMMUNE PHARM, V7, P24
Bilbo SD, 2009, FRONT BEHAV NEUROSCI, V3, DOI 10.3389/neuro.08.014.2009
Bilbo SD, 2008, BRAIN BEHAV IMMUN, V22, P451, DOI 10.1016/j.bbi.2007.10.003
Bilbo SD, 2006, BEHAV BRAIN RES, V169, P39, DOI 10.1016/j.bbr.2005.12.002
Bilbo SD, 2010, NEUROBIOL LEARN MEM, V94, P57, DOI 10.1016/j.nlm.2010.04.001
Bilbo SD, 2005, BEHAV NEUROSCI, V119, P293, DOI 10.1037/0735-7044.119.1.293
Bilbo SD, 2010, FASEB J, V24, P2104, DOI 10.1096/fj.09-144014
Blatteis CM, 2007, PROG BRAIN RES, V162, P3, DOI 10.1016/S0079-6123(06)62001-3
Boulanger LM, 2009, NEURON, V64, P93, DOI 10.1016/j.neuron.2009.09.001
Bouman A, 2005, HUM REPROD UPDATE, V11, P411, DOI 10.1093/humupd/dmi008
Bushong EA, 2002, J NEUROSCI, V22, P183
Bushong EA, 2004, INT J DEV NEUROSCI, V22, P73, DOI 10.1016/j.ijdeveneu.2003.12.008
Capuron L, 2011, PHARMACOL THERAPEUT, V130, P226, DOI 10.1016/j.pharmthera.2011.01.014
Careaga M, 2010, NEUROTHERAPEUTICS, V7, P283, DOI 10.1016/j.nurt.2010.05.003
Caserta MT, 2009, INT REV NEUROBIOL, V84, P1, DOI 10.1016/S0074-7742(09)00401-2
Caspi A, 2006, NAT REV NEUROSCI, V7, P583, DOI 10.1038/nrn1925
Chan WY, 2007, BRAIN RES REV, V53, P344, DOI 10.1016/j.brainresrev.2006.11.002
Cooper GS, 2003, AUTOIMMUN REV, V2, P119, DOI 10.1016/S1568-9972(03)00006-5
Cuadros MA, 1998, PROG NEUROBIOL, V56, P173, DOI 10.1016/S0301-0082(98)00035-5
Cutolo M, 2004, LUPUS, V13, P635, DOI 10.1191/0961203304lu1094oa
Czlonkowska A, 2011, J NEUROIMMUNOL, V231, P78, DOI 10.1016/j.jneuroim.2010.09.020
Dantzer R, 2007, BRAIN BEHAV IMMUN, V21, P153, DOI 10.1016/j.bbi.2006.09.006
Dantzer R, 2006, NEUROL CLIN, V24, P441, DOI 10.1016/j.ncl.2006.03.003
d'Elia HF, 2008, SCAND J IMMUNOL, V68, P661, DOI 10.1111/j.1365-3083.2008.02186.x
Deverman BE, 2009, NEURON, V64, P61, DOI 10.1016/j.neuron.2009.09.002
Drew PD, 2000, J NEUROIMMUNOL, V111, P77, DOI 10.1016/S0165-5728(00)00386-6
Drew PD, 2003, ANN NY ACAD SCI, V1007, P329, DOI 10.1196/annals.1286.031
Eens M, 2000, HORM BEHAV, V37, P126, DOI 10.1006/hbeh.1999.1569
Eroglu C, 2010, NATURE, V468, P223, DOI 10.1038/nature09612
Freeman MR, 2010, SCIENCE, V330, P774, DOI 10.1126/science.1190928
Gaillard RC, 1998, DOMEST ANIM ENDOCRIN, V15, P345, DOI 10.1016/S0739-7240(98)00028-9
Garay Paula A, 2010, Front Synaptic Neurosci, V2, P136, DOI 10.3389/fnsyn.2010.00136
Gate D, 2010, J NEURAL TRANSM, V117, P961, DOI 10.1007/s00702-010-0422-7
Ginhoux F, 2010, SCIENCE, V330, P841, DOI 10.1126/science.1194637
GIULIAN D, 1988, J NEUROSCI, V8, P709
Gorina R, 2011, GLIA, V59, P242, DOI 10.1002/glia.21094
Gottfried-Blackmore A, 2008, J STEROID BIOCHEM, V109, P96, DOI 10.1016/j.jsbmb.2007.12.013
Gottfried-Blackmore A, 2010, GLIA, V58, P1257, DOI 10.1002/glia.21007
GROSSMAN C, 1989, J STEROID BIOCHEM, V34, P241, DOI 10.1016/0022-4731(89)90088-5
Gu F, 2011, CHINESE MED J-PEKING, V124, P3394, DOI 10.3760/cma.j.issn.0366-6999.2011.20.033
Halassa MM, 2009, NEUROPHARMACOLOGY, V57, P343, DOI 10.1016/j.neuropharm.2009.06.031
Hilton GD, 2003, NEUROSCIENCE, V116, P383, DOI 10.1016/S0306-4522(02)00716-9
Hodgson DM, 2002, PSYCHONEUROENDOCRINO, V27, P791, DOI 10.1016/S0306-4530(01)00080-4
Holman S, 2001, J NEUROBIOL, V47, P150, DOI 10.1002/neu.1022
Holman SD, 1998, NEUROSCI BIOBEHAV R, V22, P725, DOI 10.1016/S0149-7634(98)00001-3
Holman SD, 1996, HORM BEHAV, V30, P662, DOI 10.1006/hbeh.1996.0067
Kentner AC, 2010, ENDOCRINOLOGY, V151, P4602, DOI 10.1210/en.2010-0583
Kettenmann H, 2011, PHYSIOL REV, V91, P461, DOI 10.1152/physrev.00011.2010
Kipp M, 2007, J NEUROENDOCRINOL, V19, P819, DOI 10.1111/j.1365-2826.2007.01588.x
Kivity S, 2010, EXPERT REV CLIN IMMU, V6, P691, DOI [10.1586/eci.10.60, 10.1586/ECI.10.60]
Klein SL, 2000, NEUROSCI BIOBEHAV R, V24, P627, DOI 10.1016/S0149-7634(00)00027-0
Klein SL, 2004, PARASITE IMMUNOL, V26, P247, DOI 10.1111/j.0141-9838.2004.00710.x
Kovacs EJ, 2002, MOL CELL ENDOCRINOL, V193, P129, DOI 10.1016/S0303-7207(02)00106-5
Kriegstein A, 2009, ANNU REV NEUROSCI, V32, P149, DOI 10.1146/annurev.neuro.051508.135600
KRZYCH U, 1981, AM J REPROD IMMUNOL, V1, P73
LAPING NJ, 1994, BRAIN PATHOL, V4, P259, DOI 10.1111/j.1750-3639.1994.tb00841.x
Lee CYD, 2010, J NEURAL TRANSM, V117, P949, DOI 10.1007/s00702-010-0433-4
Libert C, 2010, NAT REV IMMUNOL, V10, P594, DOI 10.1038/nri2815
Lleo A, 2008, AUTOIMMUN REV, V7, P626, DOI 10.1016/j.autrev.2008.06.009
Llorente R, 2009, INT J DEV NEUROSCI, V27, P233, DOI 10.1016/j.ijdevneu.2009.01.002
Lynch MA, 2009, MOL NEUROBIOL, V40, P139, DOI 10.1007/s12035-009-8077-9
Male D, 2001, Prog Brain Res, V132, P81
McCarthy MM, 2003, ANN NY ACAD SCI, V1007, P283, DOI 10.1196/annals.1286.027
McCarthy MM, 2011, NAT NEUROSCI, V14, P677, DOI 10.1038/nn.2834
McClelland EE, 2011, ARCH IMMUNOL THER EX, V59, P203, DOI 10.1007/s00005-011-0124-3
McCombe PA, 2009, CURR MOL MED, V9, P1058
MCMILLEN MM, 1979, SCIENCE, V204, P89, DOI 10.1126/science.571144
Milner TA, 2005, J COMP NEUROL, V491, P81, DOI 10.1002/cne.20724
Mong JA, 1996, HORM BEHAV, V30, P553, DOI 10.1006/hbeh.1996.0058
Mong JA, 1999, J NEUROSCI, V19, P1464
Mouton PR, 2002, PRINCIPLES PRACTICES
Muller N, 1998, PROG NEURO-PSYCHOPH, V22, P1, DOI 10.1016/S0278-5846(97)00179-6
Muller W, 2005, P ROY SOC B-BIOL SCI, V272, P1971, DOI 10.1098/rspb.2005.3178
NAVARRA P, 1991, ENDOCRINOLOGY, V128, P37
Nunez JL, 2003, EXP NEUROL, V181, P258, DOI 10.1016/S0014-4886(03)00053-0
Olsen NJ, 1996, ENDOCR REV, V17, P369, DOI 10.1210/er.17.4.369
Pace TWW, 2011, BRAIN BEHAV IMMUN, V25, P6, DOI 10.1016/j.bbi.2010.10.003
Perea G, 2009, TRENDS NEUROSCI, V32, P421, DOI 10.1016/j.tins.2009.05.001
PERRY VH, 1985, NEUROSCIENCE, V15, P313, DOI 10.1016/0306-4522(85)90215-5
Pessach IM, 2010, CURR ALLERGY ASTHM R, V10, P311, DOI 10.1007/s11882-010-0127-x
Pfrieger FW, 2010, BRAIN RES REV, V63, P39, DOI 10.1016/j.brainresrev.2009.11.002
Poulin R, 1996, INT J PARASITOL, V26, P1311, DOI 10.1016/S0020-7519(96)00108-7
Ransohoff RM, 2009, ANNU REV IMMUNOL, V27, P119, DOI 10.1146/annurev.immunol.021908.132528
Rezaie P, 1999, DEV BRAIN RES, V115, P71, DOI 10.1016/S0165-3806(99)00043-7
Robel S, 2011, NAT REV NEUROSCI, V12, P88, DOI 10.1038/nrn2978
Roberts M, 2009, J EXP BIOL, V212, P1811, DOI 10.1242/jeb.031047
Roberts ML, 2007, HORM BEHAV, V51, P126, DOI 10.1016/j.yhbeh.2006.09.004
Robinson E. B., 2011, BEHAV GENET, V42, P245
Rutter M, 2006, J CHILD PSYCHOL PSYC, V47, P226, DOI 10.1111/j.1469-7610.2005.01557.x
Santos-Galindo María, 2011, Biol Sex Differ, V2, P7, DOI 10.1186/2042-6410-2-7
SAPOLSKY R, 1987, SCIENCE, V238, P522, DOI 10.1126/science.2821621
Schneider CP, 2006, J APPL PHYSIOL, V100, P826, DOI 10.1152/japplphysiol.00898.2005
SCHUURS AHWM, 1990, J STEROID BIOCHEM, V35, P157, DOI 10.1016/0022-4731(90)90270-3
Schwarz JM, 2011, NEUROSCI LETT, V497, P110, DOI 10.1016/j.neulet.2011.04.042
Schwarz JM, 2012, J NEUROCHEM, V120, P948, DOI 10.1111/j.1471-4159.2011.07630.x
SEAMAN WE, 1979, ARTHRITIS RHEUM, V22, P1234, DOI 10.1002/art.1780221110
Selmi C, 2008, BEST PRACT RES CL RH, V22, P913, DOI 10.1016/j.berh.2008.09.002
Sharif A, 2010, NEUROCHEM INT, V57, P344, DOI 10.1016/j.neuint.2010.05.012
Sisk CL, 2005, FRONT NEUROENDOCRIN, V26, P163, DOI 10.1016/j.yfrne.2005.10.003
Song WX, 2008, VACCINE, V26, P5741, DOI 10.1016/j.vaccine.2008.08.020
Stipursky J, 2011, LIFE SCI, V89, P524, DOI 10.1016/j.lfs.2011.04.005
Swaab DF, 2004, GYNECOL ENDOCRINOL, V19, P301, DOI 10.1080/09513590400018231
Takizawa T, 2001, DEV CELL, V1, P749, DOI 10.1016/S1534-5807(01)00101-0
Toyokawa S., 2011, SOC SCI MED, V74, P67
Tremblay Marie-Ève, 2011, Commun Integr Biol, V4, P220, DOI 10.4161/cib.4.2.14506
Tremblay ME, 2011, J NEUROSCI, V31, P16064, DOI 10.1523/JNEUROSCI.4158-11.2011
Tremblay ME, 2010, PLOS BIOL, V8, DOI 10.1371/journal.pbio.1000527
Veiga S, 2004, REV NEUROLOGIA, V39, P1043
VISELLI SM, 1995, IMMUNOLOGY, V84, P337
Walker AK, 2011, BRAIN BEHAV IMMUN, V25, P674, DOI 10.1016/j.bbi.2011.01.004
Wang CC, 2002, DEV BRAIN RES, V139, P337, DOI 10.1016/S0165-3806(02)00584-9
WASHBURN TC, 1965, PEDIATRICS, V35, P57
Watanabe Y, 2010, PSYCHIAT CLIN NEUROS, V64, P217, DOI 10.1111/j.1440-1819.2010.02094.x
Williamson LL, 2011, J NEUROSCI, V31, P15511, DOI 10.1523/JNEUROSCI.3688-11.2011
Wright CL, 2009, J NEUROSCI, V29, P13274, DOI 10.1523/JNEUROSCI.3603-09.2009
Wright CL, 2008, DEV NEUROBIOL, V68, P1406, DOI 10.1002/dneu.20665
XU J, 1993, J ANAT, V182, P55
Zhang Y, 2010, CURR OPIN NEUROBIOL, V20, P588, DOI 10.1016/j.conb.2010.06.005
Zuk M, 1996, INT J PARASITOL, V26, P1009, DOI 10.1016/S0020-7519(96)80001-4
NR 133
TC 27
Z9 27
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0018-506X
J9 HORM BEHAV
JI Horm. Behav.
PD AUG
PY 2012
VL 62
IS 3
BP 243
EP 253
DI 10.1016/j.yhbeh.2012.02.018
PG 11
WC Behavioral Sciences; Endocrinology & Metabolism
SC Behavioral Sciences; Endocrinology & Metabolism
GA 022GR
UT WOS:000309946300008
PM 22387107
ER
PT J
AU Deschamps, PKH
Schutte, I
Kenemans, JL
Matthys, W
Schutter, DJLG
AF Deschamps, P. K. H.
Schutte, I.
Kenemans, J. L.
Matthys, W.
Schutter, D. J. L. G.
TI Electromyographic responses to emotional facial expressions in 6-7 year
olds: A feasibility study
SO INTERNATIONAL JOURNAL OF PSYCHOPHYSIOLOGY
LA English
DT Article
DE Children; Electromyography; Emotional responsiveness; Facial mimicry
ID DISRUPTIVE BEHAVIOR DISORDERS; AUTISM SPECTRUM DISORDERS; CHILDREN;
MIMICRY; FACES; EMG; SADNESS; BOYS
AB Preliminary studies have demonstrated that school-aged children (average age 9-10 years) show mimicry responses to happy and angry facial expressions. The aim of the present study was to assess the feasibility of using facial electromyography (EMG) as a method to study facial mimicry responses in younger children aged 6-7 years to emotional facial expressions of other children. Facial EMG activity to the presentation of dynamic emotional faces was recorded from the corrugator, zygomaticus, frontalis and depressor muscle in sixty-one healthy participants aged 6-7 years. Results showed that the presentation of angry faces was associated with corrugator activation and zygomaticus relaxation, happy faces with an increase in zygomaticus and a decrease in corrugator activation, fearful faces with frontalis activation, and sad faces with a combination of corrugator and frontalis activation. This study demonstrates the feasibility of measuring facial EMG response to emotional facial expressions in 6-7 year old children. (C) 2012 Elsevier B.V. All rights reserved.
C1 [Deschamps, P. K. H.; Matthys, W.] Univ Med Ctr Utrecht, Dept Child & Adolescent Psychiat, Utrecht, Netherlands.
[Schutte, I.; Kenemans, J. L.; Schutter, D. J. L. G.] Univ Utrecht, Helmholtz Res Inst, Dept Expt Psychol, NL-3508 TC Utrecht, Netherlands.
[Deschamps, P. K. H.; Matthys, W.] Univ Med Ctr Utrecht, Rudolf Magnus Inst Neurosci, Utrecht, Netherlands.
RP Deschamps, PKH (reprint author), UMC Utrecht, Dept Child & Adolescent Psychiat, Postbus 85500,HP A01-468, NL-3508 GA Utrecht, Netherlands.
EM p.k.h.deschamps@umcutrecht.nl
FU Netherlands Organization for Scientific Research (NWO) [VIDI 452-07-012]
FX Dennis J.L.G Schutter was supported by an Innovational Research Grant
(VIDI 452-07-012) from the Netherlands Organization for Scientific
Research (NWO).
CR Barbaro J, 2009, J DEV BEHAV PEDIATR, V30, P447, DOI 10.1097/DBP.0b013e3181ba0f9f
Beall PM, 2008, J EXP CHILD PSYCHOL, V101, P206, DOI 10.1016/j.jecp.2008.04.004
BERNIERI FJ, 1988, J PERS SOC PSYCHOL, V54, P243, DOI 10.1037//0022-3514.54.2.243
Bourgeois P, 2008, BIOL PSYCHOL, V77, P343, DOI 10.1016/j.biopsycho.2007.11.008
BUCK R, 1994, BIOL PSYCHOL, V38, P95, DOI 10.1016/0301-0511(94)90032-9
CACIOPPO JT, 1986, J PERS SOC PSYCHOL, V50, P260, DOI 10.1037//0022-3514.50.2.260
CAMRAS LA, 1988, DEV PSYCHOL, V24, P776, DOI 10.1037//0012-1649.24.6.776
CAMRAS LA, 1993, CHILD ABUSE NEGLECT, V17, P455, DOI 10.1016/0145-2134(93)90020-6
CAPPELLA JN, 1981, HUM COMMUN RES, V7, P117, DOI 10.1111/j.1468-2958.1981.tb00564.x
Chartrand TL, 1999, J PERS SOC PSYCHOL, V76, P893, DOI 10.1037//0022-3514.76.6.893
CHISHOLM K, 1995, J EXP CHILD PSYCHOL, V59, P299, DOI 10.1006/jecp.1995.1013
Dadds MR, 2007, CHILD PSYCHIAT HUMAN, V39, P111
Decety J, 2007, BIOPYSCHOSOCIAL MED, V1, P1
de Wied M, 2006, J PSYCHIAT RES, V40, P112, DOI 10.1016/j.jpsychires.2005.08.003
De Wied M, 2009, PSYCHOPHYSIOLOGY, V46, P996, DOI 10.1111/j.1469-8986.2009.00851.x
Eisenberg N, 2010, SOC ISS POLICY REV, V4, P143, DOI 10.1111/j.17512409.2010.01020.x
DIMBERG U, 1990, PSYCHOPHYSIOLOGY, V27, P481, DOI 10.1111/j.1469-8986.1990.tb01962.x
Dimberg U, 2000, PSYCHOPHYSIOLOGY, V37, P693, DOI 10.1017/S0048577200990759
Dimberg U, 1998, SCAND J PSYCHOL, V39, P39, DOI 10.1111/1467-9450.00054
Ekman P., 1978, FACIAL ACTION CODING
FRIDLUND AJ, 1986, PSYCHOPHYSIOLOGY, V23, P567, DOI 10.1111/j.1469-8986.1986.tb00676.x
HAVILAND JM, 1987, DEV PSYCHOL, V23, P97, DOI 10.1037/0012-1649.23.1.97
Hermans EJ, 2006, PSYCHONEUROENDOCRINO, V31, P859, DOI 10.1016/j.psyneuen.2006.04.002
Kohler CG, 2004, PSYCHIAT RES, V128, P235, DOI 10.1016/j.psychres.2004.07.003
Kort W., 2005, HANDLEIDING VERANTWO
Kreibig SD, 2007, PSYCHOPHYSIOLOGY, V44, P787, DOI 10.1111/j.1469-8986.2007.00550.x
Larsen JT, 2009, PSYCHOPHYSIOLOGY, V46, P831, DOI 10.1111/j.1469-8986.2009.00820.x
Magnee MJCM, 2007, J CHILD PSYCHOL PSYC, V48, P1122, DOI 10.1111/j.1469-7610.2007.01779.x
Mass R, 2008, SCAND J PSYCHOL, V49, P293, DOI 10.1111/j.1467-9450.2008.00645.x
Moffitt TE, 2008, J CHILD PSYCHOL PSYC, V49, P3, DOI 10.1111/j.1469-7610.2007.01823.x
Moody EJ, 2007, EMOTION, V7, P447, DOI 10.1037/1528-3542.7.2.447
Oberman LM, 2009, DEVELOPMENTAL SCI, V12, P510, DOI 10.1111/j.1467-7687.2008.00796.x
Rymarczyk K, 2011, INT J PSYCHOPHYSIOL, V79, P330, DOI 10.1016/j.ijpsycho.2010.11.001
Sattler J.M., 1992, ASSESSMENT CHILDREN
SCHWARTZ GE, 1976, PSYCHOSOM MED, V38, P337
Sonnby-Borgstrom M, 2008, SCAND J PSYCHOL, V49, P111, DOI 10.1111/j.1467-9450.2008.00626.x
Steiner Hans, 2007, J Am Acad Child Adolesc Psychiatry, V46, P126
Weyers P, 2006, PSYCHOPHYSIOLOGY, V43, P450, DOI 10.1111/j.1469-8986.2006.00451.x
Weyers P, 2009, PSYCHOPHYSIOLOGY, V46, P328, DOI 10.1111/j.1469-8986.2008.00771.x
NR 39
TC 4
Z9 5
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0167-8760
J9 INT J PSYCHOPHYSIOL
JI Int. J. Psychophysiol.
PD AUG
PY 2012
VL 85
IS 2
BP 195
EP 199
DI 10.1016/j.ijpsycho.2012.05.004
PG 5
WC Psychology, Biological; Neurosciences; Physiology; Psychology;
Psychology, Experimental
SC Psychology; Neurosciences & Neurology; Physiology
GA 020DZ
UT WOS:000309790400008
PM 22634269
ER
PT J
AU Cuellar, M
Bowers, A
Harkrider, AW
Wilson, M
Saltuklaroglu, T
AF Cuellar, Megan
Bowers, Andrew
Harkrider, Ashley W.
Wilson, Matthew
Saltuklaroglu, Tim
TI Mu suppression as an index of sensorimotor contributions to speech
processing: Evidence from continuous EEG signals
SO INTERNATIONAL JOURNAL OF PSYCHOPHYSIOLOGY
LA English
DT Article
DE Phonological discrimination; Sub lexical; Electroencephalography
ID INDEPENDENT COMPONENT ANALYSIS; AUTISM SPECTRUM DISORDERS; FUNCTIONAL
NEUROANATOMY; PREFRONTAL CORTEX; ALPHA BAND; PERCEPTION; BRAIN;
SYNCHRONIZATION; SEGMENTATION; ORGANIZATION
AB Mu rhythm suppression is an index of sensorimotor activity during the processing of sensory stimuli. Two present studies investigate the extent to which this measure is sensitive to differences in acoustic processing. In both studies, participants were required to listen to 90 second acoustic stimuli clips with their eyes closed and identify predetermined targets. Experimental conditions were designed to vary the acoustic processing demands. Mu suppression was measured continuously across central electrodes (C3, Cz, and C4). Ten adult females participated in the first study in which the target was a pseudoword presented in three conditions (identification, discrimination, discrimination in noise). Mu suppression was strongest and reached significance relative to baseline only in the discrimination in noise task at C3 (indicative of left hemisphere sensorimotor activity) when measured in a 10-12 Hz bandwidth. Thirteen adult females participated in the second study, which measured mu suppression to acoustic stimuli with 'segmentation' (i.e., separating a parsed stimulus into individual components) versus non-segmentation requirements in both speech and tone discrimination conditions. Significantly greater overall suppression to speech relative to tone tasks was found in the 10-12 Hz bandwidth. Further, suppression relative to baseline was significant only at C3 during the speech discrimination with segmentation task. Taken together, findings indicate that mu rhythm suppression in acoustic processing is sensitive to dorsal stream processing. More specifically, it is sensitive to (1) increases in overall processing demands and (2) processing linguistic versus non-linguistic information. (C) 2012 Elsevier B.V. All rights reserved.
C1 [Cuellar, Megan; Bowers, Andrew; Harkrider, Ashley W.; Wilson, Matthew; Saltuklaroglu, Tim] Univ Tennessee, Coll Allied Hlth Sci, Dept Audiol & Speech Pathol, Knoxville, TN 37996 USA.
RP Cuellar, M (reprint author), Univ Tennessee, Coll Allied Hlth Sci, Dept Audiol & Speech Pathol, Knoxville, TN 37996 USA.
EM mmorris5@uthsc.edu
CR Aziz-Zadeh L, 2009, ADV EXP MED BIOL, V629, P355, DOI 10.1007/978-0-387-77064-2_18
Barry RJ, 2007, CLIN NEUROPHYSIOL, V118, P2765, DOI 10.1016/j.clinph.2007.07.028
Binder JR, 2004, NAT NEUROSCI, V7, P295, DOI 10.1038/nn1198
Buccino G., 2010, DEV PSYCHOBIOL, V54, P295
Burton MW, 2006, CORTEX, V42, P644, DOI 10.1016/S0010-9452(08)70400-3
Burton MW, 2009, CLIN LINGUIST PHONET, V23, P180, DOI 10.1080/02699200802394963
Burton MW, 2000, J COGNITIVE NEUROSCI, V12, P679, DOI 10.1162/089892900562309
Burton MW, 2005, NEUROIMAGE, V26, P647, DOI 10.1016/j.neuroimage.2005.02.024
Callan D, 2010, NEUROIMAGE, V51, P844, DOI 10.1016/j.neuroimage.2010.02.027
Callan DE, 2001, COGNITIVE BRAIN RES, V10, P349, DOI 10.1016/S0926-6410(00)00054-9
Cheng Y., 2008, PLOS ONE, V3
Crawcour S, 2009, NEUROPSYCHOLOGIA, V47, P2558, DOI 10.1016/j.neuropsychologia.2009.05.001
Eisner F, 2010, J NEUROSCI, V30, P7179, DOI 10.1523/JNEUROSCI.4040-09.2010
Galantucci B, 2006, PSYCHON B REV, V13, P361, DOI 10.3758/BF03193857
Hari R, 2006, PROG BRAIN RES, V159, P253, DOI 10.1016/S0079-6123(06)59017-X
Hickok G, 2004, COGNITION, V92, P67, DOI 10.1016/j.cognition.2003.10.011
Hickok G, 2007, NAT REV NEUROSCI, V8, P393, DOI 10.1038/nrn2113
Hickok G, 2011, NEURON, V69, P407, DOI 10.1016/j.neuron.2011.01.019
Hickok G, 2009, PHYS LIFE REV, V6, P121, DOI 10.1016/j.plrev.2009.06.001
Jasper H. H., 1958, ELECTROENCEPHALOGRAP, V10, P371, DOI DOI 10.1016/0013-4694(58)90053-1
Jung TP, 2000, PSYCHOPHYSIOLOGY, V37, P163, DOI 10.1017/S0048577200980259
Kalinowski J, 2003, NEUROSCI BIOBEHAV R, V27, P339, DOI 10.1016/S0149-7634(03)00063-0
Klimesch W, 1998, NEUROSCI LETT, V244, P73, DOI 10.1016/S0304-3940(98)00122-0
Kotz SA, 2010, BRAIN LANG, V112, P3, DOI 10.1016/j.bandl.2009.07.008
Krause CM, 1997, COGNITIVE BRAIN RES, V5, P295, DOI 10.1016/S0926-6410(97)00009-8
Laufs H., 2003, NEUROIMAGE, V19, P1453
Le Bel RM, 2009, J COMMUN DISORD, V42, P299, DOI 10.1016/j.jcomdis.2009.03.011
Lepage JF, 2010, NEUROREPORT, V21, P250, DOI 10.1097/WNR.0b013e328334ddcc
LoCasto PC, 2004, J COGNITIVE NEUROSCI, V16, P1612, DOI 10.1162/0898929042568433
Lotto AJ, 2009, TRENDS COGN SCI, V13, P110, DOI 10.1016/j.tics.2008.11.008
Muthukumaraswamy SD, 2006, BRAIN RES, V1071, P105, DOI 10.1016/j.brainres.2005.11.053
Muthukumaraswamy S.D., 2004, COGNITIVE BRAIN RES, V19, P95
Oberman LM, 2008, NEUROPSYCHOLOGIA, V46, P1558, DOI 10.1016/j.neuropsychologia.2008.01.010
Oberman LM, 2005, COGNITIVE BRAIN RES, V24, P190, DOI 10.1016/j.cogbrainres.2005.01.014
Onton J, 2006, NEUROSCI BIOBEHAV R, V30, P808, DOI 10.1016/j.neubiorev.2006.06.007
Onton J, 2006, PROG BRAIN RES, V159, P99, DOI 10.1016/S0079-6123(06)59007-7
Pascual-Marqui RD, 2002, METHOD FIND EXP CLIN, V24, P5
Perry A, 2009, BRAIN RES, V1282, P126, DOI 10.1016/j.brainres.2009.05.059
Petsche H, 1997, INT J PSYCHOPHYSIOL, V26, P77, DOI 10.1016/S0167-8760(97)00757-5
PFURTSCHELLER G, 1990, Brain Topography, V3, P85, DOI 10.1007/BF01128865
Pfurtscheller G, 1996, INT J PSYCHOPHYSIOL, V24, P39, DOI 10.1016/S0167-8760(96)00066-9
Pineda JA, 2009, BIOL PSYCHOL, V80, P306, DOI 10.1016/j.biopsycho.2008.11.003
Pineda JA, 2005, BRAIN RES REV, V50, P57, DOI 10.1016/j.brainresrev.2005.04.005
Poldrack RA, 1999, NEUROIMAGE, V10, P15, DOI 10.1006/nimg.1999.0441
REMEZ RE, 1981, SCIENCE, V212, P947, DOI 10.1126/science.7233191
Sato M, 2009, BRAIN LANG, V111, P1, DOI 10.1016/j.bandl.2009.03.002
Skipper JI, 2005, NEUROIMAGE, V25, P76, DOI 10.1016/j.neuroimage.2004.11.006
Ulloa ER, 2007, BEHAV BRAIN RES, V183, P188, DOI 10.1016/j.bbr.2007.06.007
Wilson SM, 2009, TRENDS COGN SCI, V13, P329, DOI 10.1016/j.tics.2009.06.001
Zatorre RJ, 1999, NEUROIMAGE, V10, P544, DOI 10.1006/nimg.1999.0491
Zekveld AA, 2006, NEUROIMAGE, V32, P1826, DOI 10.1016/j.neuroimage.2006.04.199
NR 51
TC 5
Z9 5
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0167-8760
J9 INT J PSYCHOPHYSIOL
JI Int. J. Psychophysiol.
PD AUG
PY 2012
VL 85
IS 2
BP 242
EP 248
DI 10.1016/j.ijpsycho.2012.04.003
PG 7
WC Psychology, Biological; Neurosciences; Physiology; Psychology;
Psychology, Experimental
SC Psychology; Neurosciences & Neurology; Physiology
GA 020DZ
UT WOS:000309790400015
PM 22522370
ER
PT J
AU Sullivan, PF
Daly, MJ
O'Donovan, M
AF Sullivan, Patrick F.
Daly, Mark J.
O'Donovan, Michael
TI DISEASE MECHANISMS Genetic architectures of psychiatric disorders: the
emerging picture and its implications
SO NATURE REVIEWS GENETICS
LA English
DT Review
ID GENOME-WIDE ASSOCIATION; AUTISM-SPECTRUM DISORDERS; DEFICIT
HYPERACTIVITY DISORDER; CANCER SUSCEPTIBILITY LOCI; COPY NUMBER
VARIATION; DE-NOVO MUTATIONS; SEROTONIN TRANSPORTER GENE; RARE
CHROMOSOMAL DELETIONS; INSTITUTES-OF-HEALTH; BIPOLAR-DISORDER
AB Psychiatric disorders are among the most intractable enigmas in medicine. In the past 5 years, there has been unprecedented progress on the genetics of many of these conditions. In this Review, we discuss the genetics of nine cardinal psychiatric disorders (namely, Alzheimer's disease, attention-deficit hyperactivity disorder, alcohol dependence, anorexia nervosa, autism spectrum disorder, bipolar disorder, major depressive disorder, nicotine dependence and schizophrenia). Empirical approaches have yielded new hypotheses about aetiology and now provide data on the often debated genetic architectures of these conditions, which have implications for future research strategies. Further study using a balanced portfolio of methods to assess multiple forms of genetic variation is likely to yield many additional new findings.
C1 [Sullivan, Patrick F.] Univ N Carolina, Dept Genet, Chapel Hill, NC 27599 USA.
[Sullivan, Patrick F.] Univ N Carolina, Dept Psychiat, Chapel Hill, NC 27599 USA.
[Daly, Mark J.] Harvard Univ, Dept Genet, Cambridge, MA 02138 USA.
[O'Donovan, Michael] Cardiff Univ, MRC Ctr Neuropsychiat Genet, Cardiff CF14 4XN, S Glam, Wales.
RP Sullivan, PF (reprint author), Univ N Carolina, Dept Genet, CB 7264, Chapel Hill, NC 27599 USA.
EM pfsulliv@med.unc.edu
FU US National Institutes of Health (NIH) [MH077139, MH085520]; UK Medical
Research Council (MRC) [G0800509, G0801418]; European Community
[HEALTH-F2-2010-241909]; NIMH [5P50MH066392-09]; Wellcome Trust
FX We remain indebted to the tens of thousand of individuals with
psychiatric disorders for their participation in genetic studies of
these disorders. We thank many colleagues for helpful critiques, plus a
wealth of conversations with colleagues in the Psychiatric Genomics
Consortium. We thank the US National Institutes of Health (NIH) for
funding (MH077139 and MH085520), T. Lehner of the US National Institute
of Mental Health (NIMH) for his continued support, B. Voight and J.
Hirschhorn for data relevant to power estimation, S. Ripke for help with
figures, J. Szatkiewicz for assistance in reviewing the structural
variation literature, and C. Bulik and J. Crowley for helpful comments.
M.O. is supported for schizophrenia research by grants from the UK
Medical Research Council (MRC) (G0800509, G0801418), the European
Community's Seventh Framework Programme (HEALTH-F2-2010-241909 (Project
EU-GEI)) and by NIMH (5P50MH066392-09). This study makes use of data
generated by DECIPHER. A full list of centres that contributed to the
generation of the data is available from http://decipher.sanger.ac.uk.
Funding for DECIPHER was provided by the Wellcome Trust. The authors
jointly conceived and wrote this paper and take responsibility for its
content.
CR Addington J, 2012, ANNU REV CLIN PSYCHO, V8, P269, DOI 10.1146/annurev-clinpsy-032511-143146
Alkan C, 2011, NAT REV GENET, V12, P363, DOI 10.1038/nrg2958
Allen HL, 2010, NATURE, V467, P832, DOI 10.1038/nature09410
Altshuler D, 2007, NAT GENET, V39, P813, DOI 10.1038/ng0707-813
American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th
Anderson CA, 2011, PLOS BIOL, V9, DOI 10.1371/journal.pbio.1000580
Anney R, 2010, HUM MOL GENET, V19, P4072, DOI 10.1093/hmg/ddq307
Aoun S, 2004, AUST NZ J PUBL HEAL, V28, P80, DOI 10.1111/j.1467-842X.2004.tb00637.x
Arcelus J, 2011, ARCH GEN PSYCHIAT, V68, P724, DOI 10.1001/archgenpsychiatry.2011.74
Attia J, 2009, JAMA-J AM MED ASSOC, V301, P74, DOI 10.1001/jama.2008.901
Baik I, 2011, AM J CLIN NUTR, V93, P809, DOI 10.3945/ajcn.110.001776
Barabasi AL, 2011, NAT REV GENET, V12, P56, DOI 10.1038/nrg2918
Bassett AS, 2000, AM J MED GENET, V97, P45, DOI 10.1002/(SICI)1096-8628(200021)97:1<45::AID-AJMG6>3.0.CO;2-9
Bemis LT, 2008, CANCER RES, V68, P1362, DOI 10.1158/0008-5472.CAN-07-2912
Bertram L, 2008, NAT REV NEUROSCI, V9, P768, DOI 10.1038/nrn2494
Betancur C, 2011, BRAIN RES, V1380, P42, DOI 10.1016/j.brainres.2010.11.078
Biederman Joseph, 2006, MedGenMed, V8, P12
Bierut L. J., 2011, MOL PSYCHIATR, V7, P445
Bierut LJ, 2010, P NATL ACAD SCI USA, V107, P5082, DOI 10.1073/pnas.0911109107
Breen G, 2011, NAT GENET, V43, P3, DOI 10.1038/ng0111-3
Brouwers N, 2012, MOL PSYCHIATR, V17, P223, DOI 10.1038/mp.2011.24
Brunetti-Pierri N, 2008, NAT GENET, V40, P1466, DOI 10.1038/ng.279
Burton PR, 2007, NATURE, V447, P661, DOI 10.1038/nature05911
Cantor RM, 2010, AM J HUM GENET, V86, P6, DOI 10.1016/j.ajhg.2009.11.017
Caspi A, 2003, SCIENCE, V301, P386, DOI 10.1126/science.1083968
Centers for Disease Control and Prevention, 2010, SEX TRANSM DIS SURV
Blake JA, 2012, NUCLEIC ACIDS RES, V40, pD559, DOI 10.1093/nar/gkr1028
Chanock SJ, 2007, NATURE, V447, P655, DOI 10.1038/447655a
Chiurazzi P, 2008, EUR J HUM GENET, V16, P422, DOI 10.1038/sj.ejhg.5201994
Cichon S, 2011, AM J HUM GENET, V88, P372, DOI 10.1016/j.ajhg.2011.01.017
Cichon S, 2009, AM J PSYCHIAT, V166, P540, DOI 10.1176/appi.ajp.2008.08091354
Cirulli ET, 2010, NAT REV GENET, V11, P415, DOI 10.1038/nrg2779
Collins AL, 2012, PSYCHOL MED, V42, P607, DOI 10.1017/S0033291711001607
Collins PY, 2011, NATURE, V475, P27, DOI 10.1038/475027a
Consortium TIS, 2009, NATURE, V460, P748, DOI 10.1038/nature08185
Cooper GM, 2011, NAT GENET, V43, P838, DOI 10.1038/ng.909
Corvin A, 2010, PSYCHOL MED, V40, P1063, DOI 10.1017/S0033291709991723
Croning MDR, 2009, NUCLEIC ACIDS RES, V37, pD846, DOI 10.1093/nar/gkn700
Davies G, 2011, MOL PSYCHIATR, V16, P996, DOI 10.1038/mp.2011.85
de Bakker P. I., 2010, COLD SPRING HARB PRO
de Bakker PIW, 2008, HUM MOL GENET, V17, pR122, DOI 10.1093/hmg/ddn288
Dickson SP, 2010, PLOS BIOL, V8, DOI 10.1371/journal.pbio.1000294
Easton DF, 2007, NATURE, V447, P1087, DOI 10.1038/nature05887
Eaton WW, 2008, EPIDEMIOL REV, V30, P1, DOI 10.1093/epirev/mxn011
Edenberg HJ, 2010, ALCOHOL CLIN EXP RES, V34, P840, DOI 10.1111/j.1530-0277.2010.01156.x
Eichler EE, 2010, NAT REV GENET, V11, P446, DOI 10.1038/nrg2809
Fergusson DM, 2011, BRIT J PSYCHIAT, V198, P129, DOI 10.1192/bjp.bp.110.085993
Ferreira MAR, 2008, NAT GENET, V40, P1056, DOI 10.1038/ng.209
Folstein SE, 2001, NAT REV GENET, V2, P943, DOI 10.1038/35103559
Fowler CD, 2011, NATURE, V471, P597, DOI 10.1038/nature09797
Frank J, 2012, ADDICT BIOL, V17, P171, DOI 10.1111/j.1369-1600.2011.00395.x
Franke A, 2010, NAT GENET, V42, P1118, DOI 10.1038/ng.717
Gillum LA, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0016837
Girard SL, 2011, NAT GENET, V43, P860, DOI 10.1038/ng.886
Green EK, 2010, MOL PSYCHIATR, V15, P1016, DOI 10.1038/mp.2009.49
Gross CP, 1999, NEW ENGL J MED, V340, P1881, DOI 10.1056/NEJM199906173402406
Grozeva D, 2010, ARCH GEN PSYCHIAT, V67, P318, DOI 10.1001/archgenpsychiatry.2010.25
Guerreiro R, 2012, NEUROBIOL AGING, V33, DOI [10.1016/j.neurobiolaging.2011.10.009, DOI 10.1016/J.NEUROBIOLAGING.2011.10.009]
Guerreiro RJ, 2011, BIOCHEM SOC T, V39, P910, DOI 10.1042/BST0390910
Harold D, 2009, NAT GENET, V41, P1088, DOI 10.1038/ng.440
Heath AC, 2011, BIOL PSYCHIAT, V70, P513, DOI 10.1016/j.biopsych.2011.02.028
Hindorff LA, 2009, P NATL ACAD SCI USA, V106, P9362, DOI 10.1073/pnas.0903103106
Hirschhorn JN, 2009, NEW ENGL J MED, V360, P1699, DOI 10.1056/NEJMp0808934
Hollingworth P, 2011, NAT GENET, V43, P429, DOI 10.1038/ng.803
Holmans P, 2009, AM J HUM GENET, V85, P13, DOI 10.1016/j.ajhg.2009.05.011
Houlston RS, 2010, NAT GENET, V42, P973, DOI 10.1038/ng.670
Inlow JK, 2004, GENETICS, V166, P835, DOI 10.1534/genetics.166.2.835
Stone JL, 2008, NATURE, V455, P237, DOI 10.1038/nature07239
Itsara A, 2009, AM J HUM GENET, V84, P148, DOI 10.1016/j.ajhg.2008.12.014
Jacquemont S, 2011, NATURE, V478, P97, DOI 10.1038/nature10406
Jones L, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0013950
Kanehisa M, 2012, NUCLEIC ACIDS RES, V40, pD109, DOI 10.1093/nar/gkr988
Karg K, 2011, ARCH GEN PSYCHIAT, V68, P444, DOI 10.1001/archgenpsychiatry.2010.189
Kendler KS, 2011, ALCOHOL CLIN EXP RES, V35, P963, DOI 10.1111/j.1530-0277.2010.01427.x
Khatri P, 2012, PLOS COMPUT BIOL, V8, DOI 10.1371/journal.pcbi.1002375
Kiezun A, 2012, NAT GENET, V44, P623, DOI 10.1038/ng.2303
Kim YJ, 2011, SCHIZOPHRENIA BULL, V37, P456, DOI 10.1093/schbul/sbr031
Kirov G, 2011, MOL PSYCHIATR, V17, P142
Kumar RA, 2008, HUM MOL GENET, V17, P628, DOI 10.1093/hmg/ddm376
Kwon E, 2013, MOL PSYCHIATR, V18, P11, DOI 10.1038/mp.2011.170
Lamarre-Cliche M, 2001, CLIN INVEST MED, V24, P83
Lambert JC, 2009, NAT GENET, V41, P1094, DOI 10.1038/ng.439
Lander ES, 2011, NATURE, V470, P187, DOI 10.1038/nature09792
Lee P., 2012, BIOINFORMATICS, DOI [10.1093/bioinformatics/bts191, DOI 10.1093/BI0INF0RMATICS/BTS191]
Lee SH, 2012, NAT GENET, V44, P247, DOI 10.1038/ng.1108
Levinson DF, 2011, AM J PSYCHIAT, V168, P302, DOI 10.1176/appi.ajp.2010.10060876
Lichtenstein P, 2009, LANCET, V373, P234, DOI 10.1016/S0140-6736(09)60072-6
Lindblad-Toh K, 2011, NATURE, V478, P476, DOI 10.1038/nature10530
Liu JZ, 2010, NAT GENET, V42, P436, DOI 10.1038/ng.572
Ma DQ, 2009, ANN HUM GENET, V73, P263, DOI 10.1111/j.1469-1809.2009.00523.x
MacArthur DG, 2012, SCIENCE, V335, P823, DOI 10.1126/science.1215040
Major Depressive Disorder Working Group of the Psychiatric GWAS Consortium, 2012, MOL PSYCHIATR, DOI [10.1038/mp.2012.21, DOI 10.1038/MP.2012.21]
Malhotra D, 2011, NEURON, V72, P951, DOI 10.1016/j.neuron.2011.11.007
Malhotra D, 2012, CELL, V148, P1223, DOI 10.1016/j.cell.2012.02.039
Marshall CR, 2008, AM J HUM GENET, V82, P477, DOI 10.1016/j.ajhg.2007.12.009
Mattheisen M, 2011, MOL PSYCHIATR, V17, P421
McCarthy MI, 2008, NAT REV GENET, V9, P356, DOI 10.1038/nrg2344
McClellan J, 2010, JAMA-J AM MED ASSOC, V303, P2523, DOI 10.1001/jama.2010.869
McKusick VA, 2007, AM J HUM GENET, V80, P588, DOI 10.1086/514346
McMahon FJ, 2010, NAT GENET, V42, P128, DOI 10.1038/ng.523
McNaughton D, 2012, NEUROBIOL AGING, V33
McQueen MB, 2005, AM J HUM GENET, V77, P582, DOI 10.1086/491603
McQuillin A, 2011, EUR J HUM GENET, V19, P588, DOI 10.1038/ejhg.2010.221
Mefford HC, 2008, NEW ENGL J MED, V359, P1685, DOI 10.1056/NEJMoa0805384
Mefford HC, 2010, PLOS GENET, V6, DOI 10.1371/journal.pgen.1000962
Mi HY, 2010, NUCLEIC ACIDS RES, V38, pD204, DOI 10.1093/nar/gkp1019
Miller G, 2010, SCIENCE, V329, P502, DOI 10.1126/science.329.5991.502
Moreno-De-Luca D, 2010, AM J HUM GENET, V87, P618, DOI 10.1016/j.ajhg.2010.10.004
Munafo MR, 2009, BIOL PSYCHIAT, V65, P211, DOI 10.1016/j.biopsych.2008.06.009
Naj AC, 2011, NAT GENET, V43, P436, DOI 10.1038/ng.801
Neale BM, 2012, NATURE, V485, P242, DOI 10.1038/nature11011
Neale BM, 2010, J AM ACAD CHILD PSY, V49, P884, DOI 10.1016/j.jaac.2010.06.008
Need A. C., AM J HUM GE IN PRESS
Ng MYM, 2009, MOL PSYCHIATR, V14, P774, DOI 10.1038/mp.2008.135
Ng SB, 2010, HUM MOL GENET, V19, pR119, DOI 10.1093/hmg/ddq390
Nicolae DL, 2010, PLOS GENET, V6, DOI 10.1371/journal.pgen.1000888
O'Donovan MC, 2008, NAT GENET, V40, P1053, DOI 10.1038/ng.201
O'Roak BJ, 2012, NATURE, V485, P246, DOI 10.1038/nature10989
Orozco G, 2010, HUM MOL GENET, V19, pR137, DOI 10.1093/hmg/ddq368
Ott J., 1999, ANAL HUMAN GENETIC L
Owen MJ, 2010, ARCH GEN PSYCHIAT, V67, P667, DOI 10.1001/archgenpsychiatry.2010.69
Park YK, 2000, AM J PUBLIC HEALTH, V90, P727, DOI 10.2105/AJPH.90.5.727
Pasaniuc B, 2012, NAT GENET, V44, P631, DOI 10.1038/ng.2283
Pe'er I, 2008, GENET EPIDEMIOL, V32, P381, DOI 10.1002/gepi.20303
PGCBDW Group, 2011, NAT GENET, V43, P977
Pinto D, 2010, NATURE, V466, P368, DOI 10.1038/nature09146
Pottier C, 2012, MOL PSYCHIATR, V17, P875, DOI 10.1038/mp.2012.15
Cichon S, 2009, MOL PSYCHIATR, V14, P10, DOI 10.1038/mp.2008.126
Raychaudhuri S, 2010, PLOS GENET, V6, DOI 10.1371/journal.pgen.1001097
Raychaudhuri S, 2009, PLOS GENET, V5, DOI 10.1371/journal.pgen.1000534
Rietschel M, 2012, MOL PSYCHIATR, V17, P906, DOI 10.1038/mp.2011.80
Risch N, 2009, JAMA-J AM MED ASSOC, V301, P2462, DOI 10.1001/jama.2009.878
Ropers HH, 2010, ANNU REV GENOM HUM G, V11, P161, DOI 10.1146/annurev-genom-082509-141640
Rossin EJ, 2011, PLOS GENET, V7, DOI 10.1371/journal.pgen.1001273
Rovelet-Lecrux A, 2006, NAT GENET, V38, P24, DOI 10.1038/ng1718
Ruano D, 2010, AM J HUM GENET, V86, P113, DOI 10.1016/j.ajhg.2009.12.006
Rucker JJH, 2013, MOL PSYCHIATR, V18, P183, DOI 10.1038/mp.2011.144
Ruderfer DM, 2011, MOL PSYCHIATR, V16, P887, DOI 10.1038/mp.2011.34
Rujescu D, 2009, HUM MOL GENET, V18, P988, DOI 10.1093/hmg/ddn351
Saccone NL, 2010, PLOS GENET, V6, DOI 10.1371/journal.pgen.1001053
Sanders SJ, 2011, NEURON, V70, P863, DOI 10.1016/j.neuron.2011.05.002
Sanders SJ, 2012, NATURE, V485, P237, DOI 10.1038/nature10945
Schumann G, 2011, P NATL ACAD SCI USA, V108, P7119, DOI 10.1073/pnas.1017288108
Sebat J, 2007, SCIENCE, V316, P445, DOI 10.1126/science.1138659
Seshadri S, 2010, JAMA-J AM MED ASSOC, V303, P1832, DOI 10.1001/jama.2010.574
Shi JX, 2009, NATURE, V460, P753, DOI 10.1038/nature08192
Shi YY, 2011, NAT GENET, V43, P1224, DOI 10.1038/ng.980
Shinawi M, 2010, J MED GENET, V47, P332, DOI 10.1136/jmg.2009.073015
Sklar P, 2008, MOL PSYCHIATR, V13, P558, DOI 10.1038/sj.mp.4002151
Smrt RD, 2010, STEM CELLS, V28, P1060, DOI 10.1002/stem.431
Speliotes EK, 2010, NAT GENET, V42, P937, DOI 10.1038/ng.686
Stahl EA, 2012, NAT GENET, V44, P483, DOI 10.1038/ng.2232
Stefansson H, 2009, NATURE, V460, P744, DOI 10.1038/nature08186
Stefansson H, 2008, NATURE, V455, P232, DOI 10.1038/nature07229
Steinberg S, 2011, HUM MOL GENET, V20, P4076, DOI 10.1093/hmg/ddr325
Stergiakouli E, 2012, AM J PSYCHIAT, V169, P186, DOI 10.1176/appi.ajp.2011.11040551
STRITTMATTER WJ, 1993, P NATL ACAD SCI USA, V90, P1977, DOI 10.1073/pnas.90.5.1977
Sullivan P, 2012, MOL PSYCHIATR, V17, P2, DOI 10.1038/mp.2011.94
Sullivan PF, 2010, NEURON, V68, P182, DOI 10.1016/j.neuron.2010.10.003
Sullivan PF, 2012, NAT MED, V18, P210, DOI 10.1038/nm.2670
Sullivan PF, 2003, ARCH GEN PSYCHIAT, V60, P1187, DOI 10.1001/archpsyc.60.12.1187
Szatmari P, 2007, NAT GENET, V39, P319, DOI 10.1038/ng1985
Szulwach KE, 2010, J CELL BIOL, V189, P127, DOI 10.1083/jcb.200908151
Furberg H, 2010, NAT GENET, V42, P441, DOI 10.1038/ng.571
Takeuchi F, 2011, CIRC J, V75, P911, DOI 10.1253/circj.CJ-10-0774
Altshuler D, 2010, NATURE, V467, P1061, DOI 10.1038/nature09534
The Schizophrenia Psychiatric Genome-Wide Association Study C, 2011, NAT GENET, V43, P969
Thorgeirsson TE, 2010, NAT GENET, V42, P448, DOI 10.1038/ng.573
Thorgeirsson TE, 2008, NATURE, V452, P638, DOI 10.1038/nature06846
Treusch S, 2011, SCIENCE, V334, P1241, DOI 10.1126/science.1213210
Trikalinos TA, 2006, MOL PSYCHIATR, V11, P29, DOI 10.1038/sj.mp.4001750
Truong T, 2010, J NATL CANCER I, V102, P959, DOI 10.1093/jnci/djq178
Turnbull C, 2010, NAT GENET, V42, P504, DOI 10.1038/ng.586
Uher R, 2010, MOL PSYCHIATR, V15, P18, DOI 10.1038/mp.2009.123
Vacic V, 2011, NATURE, V471, P499, DOI 10.1038/nature09884
Visscher PM, 2012, AM J HUM GENET, V90, P7, DOI 10.1016/j.ajhg.2011.11.029
Voight BF, 2010, NAT GENET, V42, P579, DOI 10.1038/ng.609
Voineagu I, 2011, NATURE, V474, P380, DOI 10.1038/nature10110
Vorstman JAS, 2006, MOL PSYCHIATR, V11, P18, DOI 10.1038/sj.mp.4001757
Walsh T, 2008, SCIENCE, V320, P539, DOI 10.1126/science.1155174
Wang K, 2009, NATURE, V459, P528, DOI 10.1038/nature07999
Wang K, 2011, MOL PSYCHIATR, V16, P949, DOI 10.1038/mp.2010.107
Waters KM, 2010, PLOS GENET, V6, DOI 10.1371/journal.pgen.1001078
Weiss LA, 2008, NEW ENGL J MED, V358, P667, DOI 10.1056/NEJMoa075974
Weiss LA, 2009, NATURE, V461, P802, DOI 10.1038/nature08490
WHO, 2008, GLOB BURD DIS 2004 U
Willemsen MH, 2011, J MED GENET, V48, P810, DOI 10.1136/jmedgenet-2011-100294
WILLIAMS H, 2010, MOL PSYCHIATR, P16
Williams NM, 2012, AM J PSYCHIAT, V169, P195, DOI 10.1176/appi.ajp.2011.11060822
Williams NM, 2010, LANCET, V376, P1401, DOI 10.1016/S0140-6736(10)61109-9
Wray NR, 2010, SCHIZOPHRENIA BULL, V36, P14, DOI 10.1093/schbul/sbp137
Wray NR, 2011, PLOS BIOL, V9, DOI 10.1371/journal.pbio.1000579
Wu EQ, 2005, J CLIN PSYCHIAT, V66, P1122
Xu B, 2011, NAT GENET, V43, P864, DOI 10.1038/ng.902
Xu B, 2008, NAT GENET, V40, P880, DOI 10.1038/ng.162
Yang J, 2010, GENET EPIDEMIOL, V34, P254, DOI 10.1002/gepi.20456
Yang JA, 2010, NAT GENET, V42, P565, DOI 10.1038/ng.608
Yaspan B. L., 2011, CURR PROTOC HUM GENE, V71, P1201
Yue WH, 2011, NAT GENET, V43, P1228, DOI 10.1038/ng.979
Zhang D, 2009, MOL PSYCHIATR, V14, P376, DOI 10.1038/mp.2008.144
Zhong L, 2009, EMBO J, V28, P3027, DOI 10.1038/emboj.2009.236
Zhou KX, 2008, AM J MED GENET B, V147B, P1392, DOI 10.1002/ajmg.b.30878
NR 202
TC 211
Z9 215
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1471-0056
J9 NAT REV GENET
JI Nat. Rev. Genet.
PD AUG
PY 2012
VL 13
IS 8
BP 537
EP 551
DI 10.1038/nrg3240
PG 15
WC Genetics & Heredity
SC Genetics & Heredity
GA 975PX
UT WOS:000306524400009
PM 22777127
ER
PT J
AU Veltman, JA
Brunner, HG
AF Veltman, Joris A.
Brunner, Han G.
TI APPLICATIONS OF NEXT-GENERATION SEQUENCING De novo mutations in human
genetic disease
SO NATURE REVIEWS GENETICS
LA English
DT Review
ID COPY NUMBER VARIATION; 17Q21.31 MICRODELETION SYNDROME; AUTISM SPECTRUM
DISORDERS; MEIOTIC RECOMBINATION HOTSPOTS; COFFIN-SIRIS SYNDROME; AGE
EFFECT MUTATIONS; PATERNAL AGE; MENTAL-RETARDATION; INTELLECTUAL
DISABILITY; DEVELOPMENTAL DELAY
AB New mutations have long been known to cause genetic disease, but their true contribution to the disease burden can only now be determined using family-based whole-genome or whole-exome sequencing approaches. In this Review we discuss recent findings suggesting that de novo mutations play a prominent part in rare and common forms of neurodevelopmental diseases, including intellectual disability, autism and schizophrenia. De novo mutations provide a mechanism by which early-onset reproductively lethal diseases remain frequent in the population. These mutations, although individually rare, may capture a significant part of the heritability for complex genetic diseases that is not detectable by genome-wide association studies.
C1 [Veltman, Joris A.; Brunner, Han G.] Radboud Univ Nijmegen, Med Ctr, Dept Human Genet, Nijmegen Ctr Mol Life Sci,Inst Genet & Metab Dis, Nijmegen, Netherlands.
RP Veltman, JA (reprint author), Radboud Univ Nijmegen, Med Ctr, Dept Human Genet, Nijmegen Ctr Mol Life Sci,Inst Genet & Metab Dis, POB 9101, Nijmegen, Netherlands.
EM j.veltman@gen.umcn.nl
RI Brunner, Han/C-9928-2013; Veltman, Joris/F-5128-2010
FU Netherlands Organization for Health Research and Development
[917-66-363]; European Research Council [281964]
FX Joris A. Veltman is supported by personal grants from the Netherlands
Organization for Health Research and Development (917-66-363) and the
European Research Council (281964).
CR ALLEN G, 1974, NATURE, V250, P436, DOI 10.1038/250436a0
Aretz S, 2007, HUM MUTAT, V28, P985, DOI 10.1002/humu.20549
Arnheim N, 2009, NAT REV GENET, V10, P478, DOI 10.1038/nrg2529
Awadalla P, 2010, AM J HUM GENET, V87, P316, DOI 10.1016/j.ajhg.2010.07.019
Bamshad MJ, 2011, NAT REV GENET, V12, P745, DOI 10.1038/nrg3031
Baudat F, 2010, SCIENCE, V327, P836, DOI 10.1126/science.1183439
Berg IL, 2011, P NATL ACAD SCI USA, V108, P12378, DOI 10.1073/pnas.1109531108
Berg IL, 2010, NAT GENET, V42, P859, DOI 10.1038/ng.658
Bunyan DJ, 2008, GENET TEST, V12, P373, DOI 10.1089/gte.2008.0012
Carlson CA, 2012, NAT METHODS, V9, P78, DOI [10.1038/nmeth.1781, 10.1038/NMETH.1781]
Chen YX, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0021137
Conrad DF, 2011, NAT GENET, V43, P712, DOI 10.1038/ng.862
Cook EH, 2008, NATURE, V455, P919, DOI 10.1038/nature07458
Cooper GM, 2005, GENOME RES, V15, P901, DOI 10.1101/gr.3577405
Crow JF, 2000, NAT REV GENET, V1, P40, DOI 10.1038/35049558
Ding L, 2010, HUM MOL GENET, V19, pR188, DOI [10.1093/hmg/ddq391, 10.1093/hmg/ddy391]
Erickson RP, 2010, MUTAT RES-REV MUTAT, V705, P96, DOI 10.1016/j.mrrev.2010.04.002
Erten S, 2011, BIODATA MIN, V4, DOI 10.1186/1756-0381-4-19
Eyre-Walker A, 2007, NAT REV GENET, V8, P610, DOI 10.1038/nrg2146
Firth HV, 2009, AM J HUM GENET, V84, P524, DOI 10.1016/j.ajhg.2009.03.010
Fragouli E, 2011, CYTOGENET GENOME RES, V133, P107, DOI 10.1159/000323801
Frank SA, 2010, P NATL ACAD SCI USA, V107, P1725, DOI 10.1073/pnas.0909343106
Gauthier J, 2010, P NATL ACAD SCI USA, V107, P7863, DOI 10.1073/pnas.0906232107
Gilissen C, 2011, GENOME BIOL, V12, DOI 10.1186/gb-2011-12-9-228
Girard SL, 2011, NAT GENET, V43, P860, DOI 10.1038/ng.886
Girirajan S, 2010, NAT GENET, V42, P203, DOI 10.1038/ng.534
Girirajan S, 2011, ANNU REV GENET, V45, P203, DOI 10.1146/annurev-genet-102209-163544
Goriely A, 2010, NAT REV GENET, V11, P589, DOI 10.1038/nrg2809-c1
Goriely A, 2010, AM J MED GENET A, V152A, P2067, DOI 10.1002/ajmg.a.33513
Goriely A, 2012, AM J HUM GENET, V90, P175, DOI 10.1016/j.ajhg.2011.12.017
GRANTHAM R, 1974, SCIENCE, V185, P862, DOI 10.1126/science.185.4154.862
Haldane JBS, 1935, J GENET, V31, P317, DOI 10.1007/BF02982403
Hamdan FF, 2009, NEW ENGL J MED, V360, P599, DOI 10.1056/NEJMoa0805392
Hamdan FF, 2011, AM J HUM GENET, V88, P306, DOI 10.1016/j.ajhg.2011.02.001
He Y, 2008, J NEUROCHEM, V106, P1493, DOI 10.1111/j.1471-4159.2008.05486.x
Hehir-Kwa JY, 2011, J MED GENET, V48, P776, DOI 10.1136/jmedgenet-2011-100147
Helderman-van den Enden ATJM, 2009, CLIN GENET, V75, P465, DOI 10.1111/j.1399-0004.2009.01173.x
Hodgkinson A, 2011, NAT REV GENET, V12, P756, DOI 10.1038/nrg3098
Hoischen A, 2011, NAT GENET, V43, P729, DOI 10.1038/ng.868
Hoischen A, 2010, NAT GENET, V42, P483, DOI 10.1038/ng.581
Huang N, 2010, PLOS GENET, V6, DOI 10.1371/journal.pgen.1001154
Hultman CM, 2011, MOL PSYCHIATR, V16, P1203, DOI 10.1038/mp.2010.121
Hussein SM, 2011, NATURE, V471, P58, DOI 10.1038/nature09871
Iossifov I, 2012, NEURON, V74, P285, DOI 10.1016/j.neuron.2012.04.009
Itsara A, 2012, AM J HUM GENET, V90, P599, DOI 10.1016/j.ajhg.2012.02.013
Itsara A, 2010, GENOME RES, V20, P1469, DOI 10.1101/gr.107680.110
KONDRASHOV AS, 1993, HUM MUTAT, V2, P229, DOI 10.1002/humu.1380020312
Kondrashov AS, 2003, HUM MUTAT, V21, P12, DOI 10.1002/humu.10147
Koolen DA, 2008, J MED GENET, V45, P710, DOI 10.1136/jmg.2008.058701
Koolen DA, 2006, NAT GENET, V38, P999, DOI 10.1038/ng1853
Koolen DA, 2009, HUM MUTAT, V30, P283, DOI 10.1002/humu.20883
Kryukov GV, 2007, AM J HUM GENET, V80, P727, DOI 10.1086/513473
Lam HYK, 2012, NAT BIOTECHNOL, V30, P78, DOI 10.1038/nbt.2065
Liang Q, 2008, P NATL ACAD SCI USA, V105, P17453, DOI 10.1073/pnas.0805638105
Limaye N, 2009, HUM MOL GENET, V18, pR65, DOI 10.1093/hmg/ddp002
Lindhurst MJ, 2011, NEW ENGL J MED, V365, P611, DOI 10.1056/NEJMoa1104017
Liu PF, 2011, CELL, V146, P888, DOI 10.1016/j.cell.2011.07.042
Lo YMD, 2010, SCI TRANSL MED, V2, DOI 10.1126/scitranslmed.3001720
Lo YMD, 2008, ANN NY ACAD SCI, V1137, P140, DOI 10.1196/annals.1448.004
Loewe L, 2010, PHILOS T R SOC B, V365, P1153, DOI 10.1098/rstb.2009.0317
Londin ER, 2011, BMC GENOMICS, V12, DOI 10.1186/1471-2164-12-464
Lynch M, 2010, P NATL ACAD SCI USA, V107, P961, DOI 10.1073/pnas.0912629107
Marshall CR, 2008, AM J HUM GENET, V82, P477, DOI 10.1016/j.ajhg.2007.12.009
McClellan J, 2010, JAMA-J AM MED ASSOC, V303, P2523, DOI 10.1001/jama.2010.869
McClellan J, 2010, CELL, V141, P210, DOI 10.1016/j.cell.2010.03.032
Meyerson M, 2010, NAT REV GENET, V11, P685, DOI 10.1038/nrg2841
Najmabadi H, 2011, NATURE, V478, P57, DOI 10.1038/nature10423
Neale BM, 2012, NATURE, V485, P242, DOI 10.1038/nature11011
Ng SB, 2010, NAT GENET, V42, P790, DOI 10.1038/ng.646
O'Dushlaine C, 2011, MOL PSYCHIATR, V16, P286, DOI 10.1038/mp.2010.7
O'Roak BJ, 2012, NATURE, V485, P246, DOI 10.1038/nature10989
O'Roak BJ, 2011, NAT GENET, V43, P585, DOI 10.1038/ng.835
Pamphlett R, 2011, J NEUROSCI METH, V197, P297, DOI 10.1016/j.jneumeth.2011.02.028
Pansuriya TC, 2011, NAT GENET, V43, P1256, DOI 10.1038/ng.1004
Pasmooij AMG, 2007, J CLIN INVEST, V117, P1240, DOI 10.1172/JCI30465
Pinto D, 2010, NATURE, V466, P368, DOI 10.1038/nature09146
Pollard KS, 2010, GENOME RES, V20, P110, DOI 10.1101/gr.097857.109
Ramensky V, 2002, NUCLEIC ACIDS RES, V30, P3894, DOI 10.1093/nar/gkf493
Raychaudhuri S, 2011, CELL, V147, P57, DOI 10.1016/j.cell.2011.09.011
Riviere JB, 2012, NAT GENET, V44, P440, DOI 10.1038/ng.1091
Roach JC, 2010, SCIENCE, V328, P636, DOI 10.1126/science.1186802
Sanders SJ, 2012, NATURE, V485, P237, DOI 10.1038/nature10945
Santen GWE, 2012, NAT GENET, V44, P379, DOI 10.1038/ng.2217
Sebat J, 2007, SCIENCE, V316, P445, DOI 10.1126/science.1138659
Sharp AJ, 2006, NAT GENET, V38, P1038, DOI 10.1038/ng1862
Shaw-Smith C, 2006, NAT GENET, V38, P1032, DOI 10.1038/ng1864
Sirmaci A, 2011, AM J HUM GENET, V89, P289, DOI 10.1016/j.ajhg.2011.06.007
Stefansson H, 2005, NAT GENET, V37, P129, DOI 10.1038/ng1508
Tome S, 2011, HUM MOL GENET, V20, P2131, DOI 10.1093/hmg/ddr099
Toriello HV, 2008, GENET MED, V10, P457, DOI 10.1097/GIM.0b013e318176fabb
Tsurusaki Y, 2012, NAT GENET, V44, P376, DOI 10.1038/ng.2219
Twigg SRF, 2006, AM J HUM GENET, V78, P999, DOI 10.1086/504440
Vadlamudi L, 2010, NEW ENGL J MED, V363, P1335, DOI 10.1056/NEJMoa0910752
van Echten-Arends J, 2011, HUM REPROD UPDATE, V17, P620, DOI 10.1093/humupd/dmr014
Vanneste E, 2009, NAT MED, V15, P577, DOI 10.1038/nm.1924
Vermeesch JR, 2011, EUR J HUM GENET, V19, P1112, DOI 10.1038/ejhg.2011.83
Vissers LELM, 2010, J MED GENET, V47, P289, DOI 10.1136/jmg.2009.072942
Vissers LELM, 2011, AM J MED GENET A, V155A, P2609, DOI 10.1002/ajmg.a.34325
Vissers LELM, 2010, NAT GENET, V42, P1109, DOI 10.1038/ng.712
Vissers LELM, 2004, NAT GENET, V36, P955, DOI 10.1038/ng1407
VOGEL F, 1975, ADV HUM GENET, V5, P223
Wang Y, 2011, MOL GENET METAB, V104, P160, DOI 10.1016/j.ymgme.2011.05.016
Webber C, 2009, PLOS GENET, V5, DOI 10.1371/journal.pgen.1000531
Xu B, 2011, NAT GENET, V43, P864, DOI 10.1038/ng.902
Xu B, 2008, NAT GENET, V40, P880, DOI 10.1038/ng.162
Zhang F, 2009, ANNU REV GENOM HUM G, V10, P451, DOI 10.1146/annurev.genom.9.081307.164217
Zhang J, 2006, CYTOGENET GENOME RES, V115, P205, DOI 10.1159/000095916
NR 107
TC 141
Z9 146
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1471-0056
J9 NAT REV GENET
JI Nat. Rev. Genet.
PD AUG
PY 2012
VL 13
IS 8
BP 565
EP 575
DI 10.1038/nrg3241
PG 11
WC Genetics & Heredity
SC Genetics & Heredity
GA 975PX
UT WOS:000306524400011
PM 22805709
ER
PT J
AU Fakira, AK
Gaspers, LD
Thomas, AP
Li, H
Jain, MR
Elkabes, S
AF Fakira, Amanda K.
Gaspers, Lawrence D.
Thomas, Andrew P.
Li, Hong
Jain, Mohit R.
Elkabes, Stella
TI Purkinje cell dysfunction and delayed death in plasma membrane calcium
ATPase 2-heterozygous mice
SO MOLECULAR AND CELLULAR NEUROSCIENCE
LA English
DT Article
DE Ataxia; Autism; Neurodegeneration; Glutamate; AMPA; Calcium channel; Ion
pump; Nitric oxide
ID LONG-TERM DEPRESSION; ACTIVATED POTASSIUM CHANNELS; NITRIC-OXIDE; RAT
CEREBELLUM; REDUCED EXPRESSION; CA2+ ATPASE; MOUSE-BRAIN; SPINAL-CORD;
NEURONS; PROTEIN
AB Purkinje cell (PC) dysfunction or death has been implicated in a number of disorders including ataxia, autism and multiple sclerosis. Plasma membrane calcium ATPase 2 (PMCA2), an important calcium (Ca2+) extrusion pump that interacts with synaptic signaling complexes, is most abundantly expressed in PCs compared to other neurons. Using the PMCA2 heterozygous mouse as a model, we investigated whether a reduction in PMCA2 levels affects PC function. We focused on Ca2+ signaling and the expression of glutamate receptors which play a key role in PC function including synaptic plasticity. We found that the amplitude of depolarization and 2-amino-3-(5-methyl-3-oxo-1,2-oxazol-4-yl)ProPanoic acid receptor (AMPAR)-mediated Ca2+ transients are significantly higher in cultured PMCA2(+/-) PCs than in PMCA2(+/+) PCs. This is due to increased Ca2+ influx, since P/Q type voltage-gated Ca2+ channel (VGCC) expression was more pronounced in PCs and cerebella of PMCA2(+/-) mice and VGCC blockade prevented the elevation in amplitude. Neuronal nitric oxide synthase (nNOS) activity was higher in PMCA2(+/-) cerebella and inhibition of nNOS or the soluble guanylate cyclase (sGC)-cyclic guanosine monophosphate (cGMP) pathway, which mediates nitric oxide (NO) signaling, reduced the amplitude of Ca2+ transients in PMCA2(+/-) PCs, in vitro. In addition, there was an age-dependent decrease in metabotropic glutamate receptor 1 (mGluR1) and AMPA receptor subunit GluR2/3 transcript and protein levels at 8 weeks of age. These changes were followed by PC loss in the 20-week-old PMCA2(+/-) mice. Our studies highlight the importance of PMCA2 in Ca2+ signaling, glutamate receptor expression and survival of Purkinje cells. (C) 2012 Elsevier Inc. All rights reserved.
C1 [Fakira, Amanda K.; Elkabes, Stella] Univ Med & Dent New Jersey, New Jersey Med Sch, Dept Neurol Surg, Newark, NJ 07103 USA.
[Fakira, Amanda K.] Univ Med & Dent New Jersey, New Jersey Med Sch, Grad Sch Biomed Sci, Newark, NJ 07103 USA.
[Gaspers, Lawrence D.; Thomas, Andrew P.] Univ Med & Dent New Jersey, New Jersey Med Sch, Dept Physiol & Pharmacol, Newark, NJ 07103 USA.
[Li, Hong; Jain, Mohit R.] Univ Med & Dent New Jersey, New Jersey Med Sch, Dept Biochem & Mol Biol, Newark, NJ 07103 USA.
[Li, Hong; Jain, Mohit R.] Univ Med & Dent New Jersey, New Jersey Med Sch, Ctr Adv Prote Res, Newark, NJ 07103 USA.
[Elkabes, Stella] Univ Med & Dent New Jersey, New Jersey Med Sch, Spine Ctr New Jersey, Reynolds Family Spine Lab, Newark, NJ 07103 USA.
RP Elkabes, S (reprint author), UMDNJ NJMS, Dept Neurol Surg, 205 S Orange Ave,F-1204, Newark, NJ 07103 USA.
EM elkabest@umdnj.edu
RI Thomas, Andrew/C-6755-2013
FU NIH-NINDS [NS046363]; UMDNJ Foundation; NIH [NS046593, T32 5T32NS051157]
FX We thank Drs. Vanessa Routh, Joseph McArdle, Michael P. Kurnellas,
Amanda Craig and Kevin Pang for valuable help and advice with some of
the experiments. We are grateful to Dr. Arnaud Nicot for carefully
reading the manuscript. The authors wish to acknowledge their
appreciation to Dr. Robert F. Heary and The Reynolds Family Spine
Laboratory members. This work was generously supported by grants
NS046363 from NIH-NINDS and UMDNJ Foundation to SE and NIH grant
NS046593 to HL. AKF was partly supported by T32 5T32NS051157 from NIH.
The authors declare no conflict of interest.
CR AIBA A, 1994, CELL, V79, P377
Bauman ML, 2005, INT J DEV NEUROSCI, V23, P183, DOI 10.1016/j.ijdevneu.2004.09.006
Bortolozzi M, 2010, J BIOL CHEM, V285, P37693, DOI 10.1074/jbc.M110.170092
BRORSON JR, 1991, J NEUROSCI, V11, P4024
Burette A, 2003, J COMP NEUROL, V467, P464, DOI 10.1002/cne.10933
Burette AC, 2010, NEUROSCIENCE, V169, P987, DOI 10.1016/j.neuroscience.2010.05.062
Carayol J, 2011, BIOL PSYCHIAT, V70, P880, DOI 10.1016/j.biopsych.2011.05.020
Chen JG, 2002, FREE RADICAL BIO MED, V32, P638, DOI 10.1016/S0891-5849(02)00748-7
DeMarco SJ, 2001, J BIOL CHEM, V276, P21594, DOI 10.1074/jbc.M101448200
Empson RM, 2010, J PHYSIOL-LONDON, V588, P907, DOI 10.1113/jphysiol.2009.182196
Fernandes D, 2007, J NEUROCHEM, V102, P454, DOI 10.1111/j.1471-4159.2007.04592.x
FROEHNER SC, 1993, ANNU REV NEUROSCI, V16, P347, DOI 10.1146/annurev.ne.16.030193.002023
Gallo EF, 2011, J NEUROSCI, V31, P6947, DOI 10.1523/JNEUROSCI.0374-11.2011
Garcia ML, 1997, MOL BRAIN RES, V45, P230, DOI 10.1016/S0169-328X(96)00253-7
Garside ML, 2009, NEUROSCIENCE, V162, P383, DOI 10.1016/j.neuroscience.2009.04.059
Gotti S, 2005, MICROSC RES TECHNIQ, V68, P13, DOI 10.1002/jemt.20219
GRUOL DL, 1987, J NEUROSCI, V7, P1271
HOCKBERGER PE, 1989, J NEUROSCI, V9, P2258
Jeromin A, 1996, J NEUROPHYSIOL, V76, P3578
Kitano J, 2003, J BIOL CHEM, V278, P25101, DOI 10.1074/jbc.M303266200
Klemmer P, 2009, J PROTEOMICS, V72, P82, DOI 10.1016/j.jprot.2008.10.005
Kovacs AD, 2002, EXP NEUROL, V174, P58, DOI 10.1006/exnr.2001.7839
Kozel PJ, 2002, HEARING RES, V164, P231, DOI 10.1016/S0378-5955(01)00420-8
Kozel PJ, 1998, J BIOL CHEM, V273, P18693, DOI 10.1074/jbc.273.30.18693
Kurnellas MP, 2010, CELL DEATH DIFFER, V17, P1501, DOI 10.1038/cdd.2010.54
Kurnellas MP, 2007, MOL CELL NEUROSCI, V34, P178, DOI 10.1016/j.mcn.2006.10.010
Lee JI, 2010, P NATL ACAD SCI USA, V107, P6016, DOI 10.1073/pnas.1000866107
Lev-Ram V, 2002, P NATL ACAD SCI USA, V99, P8389, DOI 10.1073/pnas.122206399
Marcoli M, 2006, NEUROCHEM INT, V49, P683, DOI 10.1016/j.neuint.2006.06.009
Marcos D, 2009, BMC NEUROSCI, V10, DOI 10.1186/1471-2202-10-112
Namiki S, 2005, J PHYSIOL-LONDON, V566, P849, DOI 10.1113/jphysiol.2005.088799
Nicot A, 2003, BRAIN, V126, P398, DOI 10.1093/brain/awg041
Pottorf WJ, 2006, J NEUROCHEM, V98, P1646, DOI 10.1111/j.1471-4159.2006.04063.x
Prasad V, 2007, ANN NY ACAD SCI, V1099, P276, DOI 10.1196/annals.1387.029
Ota KT, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0011236
Sgambato-Faure V, 2006, BIOCHEM BIOPH RES CO, V343, P630, DOI 10.1016/j.bbrc.2006.03.020
Shibuki K, 1997, J PHYSIOL-LONDON, V498, P443
SHIGEMOTO R, 1994, NEURON, V12, P1245, DOI 10.1016/0896-6273(94)90441-3
Shin JH, 2005, J NEUROPHYSIOL, V94, P4281, DOI 10.1152/jn.00661.2005
Souayah N, 2008, EXP NEUROL, V214, P341, DOI 10.1016/j.expneurol.2008.09.002
Spiden S.L., 2008, PLOS GENET, V10
STAUFFER TP, 1995, J BIOL CHEM, V270, P12184
Steinberg JP, 2006, NEURON, V49, P845, DOI 10.1016/j.neuron.2006.02.025
Suarez I, 2005, BRAIN RES, V1047, P205, DOI 10.1016/j.brainres.2005.04.035
Womack MD, 2000, J GEN PHYSIOL, V115, P339, DOI 10.1085/jgp.115.3.339
Womack MD, 2004, J NEUROSCI, V24, P8818, DOI 10.1523/JNEUROSCI.2915-04.2004
Womack MD, 2003, J NEUROSCI, V23, P2600
Xu L, 2007, NITRIC OXIDE-BIOL CH, V17, P18, DOI 10.1016/j.niox.2007.04.004
NR 48
TC 1
Z9 1
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 1044-7431
J9 MOL CELL NEUROSCI
JI Mol. Cell. Neurosci.
PD AUG
PY 2012
VL 51
IS 1-2
BP 22
EP 31
DI 10.1016/j.mcn.2012.07.001
PG 10
WC Neurosciences
SC Neurosciences & Neurology
GA 014KH
UT WOS:000309374100003
PM 22789621
ER
PT J
AU Antar, LN
Hollander, E
AF Antar, Laura N.
Hollander, Eric
TI This issue: Case Challenges in Autism Spectrum Disorder
SO PSYCHIATRIC ANNALS
LA English
DT Editorial Material
C1 [Hollander, Eric] Albert Einstein Coll Med, New York, NY USA.
RP Antar, LN (reprint author), Montefiore Med Ctr, Albert Einstein Coll Med, Dept Psychiat & Behav Sci, New York, NY USA.
CR Boyd K, 2011, J PSYCHIATR NEUROSCI, V36, P35
Davis NO, 2012, NEUROTHERAPEUTICS
Rossignol DA, 2012, MOL PSYCHIATR, V17, P389, DOI 10.1038/mp.2011.165
Siminoff E, 2008, J AM ACAD CHILD ADOL, V47, p921Y
NR 4
TC 0
Z9 0
PU SLACK INC
PI THOROFARE
PA 6900 GROVE RD, THOROFARE, NJ 08086 USA
SN 0048-5713
J9 PSYCHIAT ANN
JI Psychiatr. Ann.
PD AUG
PY 2012
VL 42
IS 8
BP 284
EP 285
DI 10.3928/00485713-20120806-03
PG 2
WC Psychiatry
SC Psychiatry
GA 014YW
UT WOS:000309412900003
ER
PT J
AU Mehta, A
AF Mehta, Amar
TI Family Complications in Autism Diagnosis
SO PSYCHIATRIC ANNALS
LA English
DT Article
ID SPECTRUM DISORDERS; PATTERNS; CHILDREN
C1 Montefiore Med Ctr, Albert Einstein Coll Med, Dept Psychiat & Behav Sci, Bronx, NY 10467 USA.
RP Mehta, A (reprint author), Montefiore Med Ctr, Albert Einstein Coll Med, Dept Psychiat & Behav Sci, 3307 Bainbridge Ave, Bronx, NY 10467 USA.
EM amehta@montefiore.org
CR Aman MG, 2005, J CHILD ADOL PSYCHOP, V15, P116, DOI 10.1089/cap.2005.15.116
American Psychiatric Association, 2000, DIAGN STAT MAN MENT
Ganz ML, 2007, ARCH PEDIAT ADOL MED, V161, P343, DOI 10.1001/archpedi.161.4.343
McGee J. P., 2001, ED CHILDREN AUTISM
Myers SM, 2007, PEDIATRICS, V120, P1162, DOI 10.1542/peds.2007-2362
Posey DJ, 2008, J CLIN INVEST, V118, P6, DOI 10.1172/JCI32483
Rogers SJ, 2008, J CLIN CHILD ADOLESC, V37, P8, DOI 10.1080/15374410701817808
Witwer A, 2005, J CHILD ADOL PSYCHOP, V15, P671, DOI 10.1089/cap.2005.15.671
NR 8
TC 0
Z9 0
PU SLACK INC
PI THOROFARE
PA 6900 GROVE RD, THOROFARE, NJ 08086 USA
SN 0048-5713
J9 PSYCHIAT ANN
JI Psychiatr. Ann.
PD AUG
PY 2012
VL 42
IS 8
BP 287
EP 289
DI 10.3928/00485713-20120806-04
PG 3
WC Psychiatry
SC Psychiatry
GA 014YW
UT WOS:000309412900004
ER
PT J
AU Budoff, H
AF Budoff, Hillarie
TI Symptoms of Anxiety in Patients with Autism Spectrum Disorder
SO PSYCHIATRIC ANNALS
LA English
DT Article
ID PERVASIVE DEVELOPMENTAL DISORDERS; CHILDREN; PDD
C1 [Budoff, Hillarie] Montefiore Med Ctr, New York, NY USA.
RP Budoff, H (reprint author), 1641 3rd Ave,Apt 30 A, New York, NY 10128 USA.
EM Htishler@yahoo.com
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
Attwood T., 2000, AUTISM, V4, P85, DOI DOI 10.1177/1362361300004001006
Autism and Developmental Disabilities Monitoring Network Surveillance Principal Investigators, 2012, MMWR SURVEILL SUMM, V61, P1
Bhardwaj A, 2005, J AUTISM DEV DISORD, V35, P135, DOI 10.1007/s10803-004-1041-7
Buitelaar JK, 1998, J CLIN PSYCHIAT, V59, P56, DOI 10.4088/JCP.v59n0203
Couturier JL, 2002, J CHILD ADOL PSYCHOP, V12, P243, DOI 10.1089/104454602760386932
Kauffmann C, 2001, PSYCHIATRY, V64, P268, DOI 10.1521/psyc.64.3.268.18456
Lang R, 2011, NEUROPSYCH DIS TREAT, V7, P27, DOI 10.2147/NDT.S10327
Ozbayrak KR, 1997, J AM ACAD CHILD PSY, V36, P7, DOI 10.1097/00004583-199701000-00011
Silveira R, 2004, INT J PSYCHIAT CLIN, V8, P179, DOI 10.1080/13651500410006143
White SW, 2009, CLIN PSYCHOL REV, V29, P216, DOI 10.1016/j.cpr.2009.01.003
NR 11
TC 0
Z9 0
PU SLACK INC
PI THOROFARE
PA 6900 GROVE RD, THOROFARE, NJ 08086 USA
SN 0048-5713
J9 PSYCHIAT ANN
JI Psychiatr. Ann.
PD AUG
PY 2012
VL 42
IS 8
BP 290
EP 292
DI 10.3928/00485713-20120806-05
PG 3
WC Psychiatry
SC Psychiatry
GA 014YW
UT WOS:000309412900005
ER
PT J
AU Ozinci, Z
Kahn, T
Antar, LN
AF Ozinci, Zeynep
Kahn, Tara
Antar, Laura N.
TI Depression in Patients with Autism Spectrum Disorder
SO PSYCHIATRIC ANNALS
LA English
DT Article
ID ANXIETY; SYMPTOMS; CHILDREN
C1 [Antar, Laura N.] Montefiore Med Ctr, Albert Einstein Coll Med, Dept Psychiat & Behav Sci, Autism & Obsess Compuls Spectrum Program, Bronx, NY 10467 USA.
RP Antar, LN (reprint author), Montefiore Med Ctr, Albert Einstein Coll Med, Dept Psychiat & Behav Sci, Autism & Obsess Compuls Spectrum Program, 3307 Bainbridge Ave,Off 5, Bronx, NY 10467 USA.
EM laura.antar@gmail.com
CR Boyd K, 2011, J PSYCHIATR NEUROSCI, V36, pE35, DOI 10.1503/jpn.110040
Hurwitz R, 2012, COCHRANE DB SYST REV, V3
Magnuson KM, 2011, J DEV BEHAV PEDIAT
Mazefsky CA, 2010, AUTISM RES, V3, P120, DOI 10.1002/aur.133
McPheeters ML, 2011, J AUTISM DEV DISORD, V41, P646, DOI 10.1007/s10803-010-1085-9
Stewart ME, 2006, AUTISM, V10, P103, DOI 10.1177/1362361306062013
Williams K, 2010, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD004677.pub2
NR 7
TC 0
Z9 0
PU SLACK INC
PI THOROFARE
PA 6900 GROVE RD, THOROFARE, NJ 08086 USA
SN 0048-5713
J9 PSYCHIAT ANN
JI Psychiatr. Ann.
PD AUG
PY 2012
VL 42
IS 8
BP 293
EP 295
DI 10.3928/00485713-20120806-06
PG 3
WC Psychiatry
SC Psychiatry
GA 014YW
UT WOS:000309412900006
ER
PT J
AU Taylor, BP
AF Taylor, Bonnie P.
TI Differentiation of Social Phobia from High-Functioning Autism Spectrum
Disorder
SO PSYCHIATRIC ANNALS
LA English
DT Article
ID PSYCHIATRIC-DISORDERS; CHILDREN
C1 [Taylor, Bonnie P.] Montefiore Med Ctr, Autism & Obsess Compuls Spectrum Program, Bronx, NY 10467 USA.
[Taylor, Bonnie P.] Albert Einstein Coll Med, Dept Psychiat & Behav Sci, Bronx, NY 10467 USA.
RP Taylor, BP (reprint author), Montefiore Med Ctr, Autism & Obsess Compuls Spectrum Program, 3307 Bainbridge Ave, Bronx, NY 10467 USA.
EM Botaylor@montefiore.org
CR Alfano CA, 2006, J ABNORM CHILD PSYCH, V34, P189, DOI 10.1007/s10802-005-9012-9
American Psychiatric Association, 2000, DIAGN STAT MAN MENT
Attwood T., 2007, COMPLETE GUIDE ASPER
Leyfer OT, 2006, J AUTISM DEV DISORD, V36, P849, DOI 10.1007/s10803-006-0123-0
Meyer JA, 2006, AUTISM, V10, P383, DOI 10.1177/1362361306064435
Simonoff E, 2008, J AM ACAD CHILD PSY, V47, P921, DOI 10.1097/CHI.0b013e318179964f
WING L, 1981, PSYCHOL MED, V11, P115
NR 7
TC 0
Z9 0
PU SLACK INC
PI THOROFARE
PA 6900 GROVE RD, THOROFARE, NJ 08086 USA
SN 0048-5713
J9 PSYCHIAT ANN
JI Psychiatr. Ann.
PD AUG
PY 2012
VL 42
IS 8
BP 296
EP 298
DI 10.3928/00485713-20120806-07
PG 3
WC Psychiatry
SC Psychiatry
GA 014YW
UT WOS:000309412900007
ER
PT J
AU Antar, LN
AF Antar, Laura N.
TI Determination of ADHD vs. Autism Spectrum Disorder
SO PSYCHIATRIC ANNALS
LA English
DT Article
ID ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; ATOMOXETINE; SYMPTOMS; PLACEBO
C1 Montefiore Med Ctr, Albert Einstein Coll Med, Dept Psychiat & Behav Sci, Autism & Obsess Compuls Spectrum Program, Bronx, NY 10467 USA.
RP Antar, LN (reprint author), Montefiore Med Ctr, Albert Einstein Coll Med, Dept Psychiat & Behav Sci, Autism & Obsess Compuls Spectrum Program, 3307 Bainbridge Ave,Off 5, Bronx, NY 10467 USA.
EM laura.antar@gmail.com
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
American Psychiatric Association, PROP REV AUT SPECTR
Arnold LE, 2006, J AM ACAD CHILD PSY, V45, P1196, DOI 10.1097/01.chi.0000231976.28719.2a
Cortese S, 2012, EXPERT REV NEUROTHER, V12, P461, DOI [10.1586/ern.12.23, 10.1586/ERN.12.23]
Davis NO, 2012, NEUROTHERAPEUTICS
Grzadzinski R, 2011, J AUTISM DEV DISORD, V41, P1178, DOI 10.1007/s10803-010-1135-3
Harfterkamp M, 2012, J AM ACAD CHILD PSY, V51, P733, DOI 10.1016/j.jaac.2012.04.011
Murray MJ, 2010, CURR PSYCHIAT REP, V12, P382, DOI 10.1007/s11920-010-0145-3
Polanczyk G, 2007, AM J PSYCHIAT, V164, P942, DOI 10.1176/appi.ajp.164.6.942
US Centers for Disease Control, 2006, PREV AUT SPECTR DIS
World Health Organisation, 1994, ICD 10 CLASS MENT BE
NR 11
TC 0
Z9 0
PU SLACK INC
PI THOROFARE
PA 6900 GROVE RD, THOROFARE, NJ 08086 USA
SN 0048-5713
J9 PSYCHIAT ANN
JI Psychiatr. Ann.
PD AUG
PY 2012
VL 42
IS 8
BP 299
EP 301
DI 10.3928/00485713-20120806-08
PG 3
WC Psychiatry
SC Psychiatry
GA 014YW
UT WOS:000309412900008
ER
PT J
AU Louw, KA
Bentley, J
Sorsdahl, K
Adnams, C
AF Louw, Kerry-Ann
Bentley, Judith
Sorsdahl, Katherine
Adnams, Colleen
TI Prevalence and patterns of medication use in children and adolescents
with autism spectrum disorders in the Western Cape
SO SOUTH AFRICAN JOURNAL OF PSYCHIATRY
LA English
DT Meeting Abstract
C1 [Louw, Kerry-Ann; Bentley, Judith; Sorsdahl, Katherine; Adnams, Colleen] Univ Cape Town, Dept Psychiat & Mental Hlth, ZA-7700 Rondebosch, South Africa.
EM kerrylouw@gmail.com
NR 0
TC 0
Z9 0
PU SA MEDICAL ASSOC HEALTH & MEDICAL PUBL GROUP
PI CLAREMONT
PA 21 DREYER ST, 4TH FLOOR, SANCLARE BLDG, CLAREMONT, 7700, SOUTH AFRICA
SN 1608-9685
J9 SAJP-S AFR J PSYCHI
JI SAJP
PD AUG
PY 2012
VL 18
IS 3
BP 109
EP 110
PG 2
WC Psychiatry
SC Psychiatry
GA 015KP
UT WOS:000309445100024
ER
PT J
AU Kino, T
Pavlatou, MG
Moraitis, AG
Nemery, RL
Raygada, M
Stratakis, CA
AF Kino, Tomoshige
Pavlatou, Maria G.
Moraitis, Andreas G.
Nemery, Robin L.
Raygada, Margarita
Stratakis, Constantine A.
TI ZNF764 Haploinsufficiency May Explain Partial Glucocorticoid, Androgen,
and Thyroid Hormone Resistance Associated with 16p11.2 Microdeletion
SO JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
LA English
DT Article
ID NUCLEAR RECEPTORS; TIF1 ALPHA; GENE; INDIVIDUALS; DELETIONS; DOMAINS;
FAMILY; AUTISM; BETA
AB Context: Nuclear hormone receptors exert their transcriptional effects through shared cofactor molecules; thus, defects in such intermediate proteins may be associated with multiple hormone resistance. Microdeletion of small chromosomal segments results in hereditary or sporadic diseases by affecting expression of residing genes.
Objectives: We describe a 7-yr-old boy with partial resistance to glucocorticoids, thyroid hormones, and possibly androgens. He was diagnosed as being in the autism spectrum disorder and had developmental delay and several facial morphological manifestations. We explored genes responsible for multiple hormone resistance of this case.
Results: We found in this patient an approximately 1.1-Mb heterozygous 16p11.2 microdeletion, which included an approximately 500-kb unique deletion along with the common, previously reported approximately 600-kb 16p11.2 microdeletion. The small interfering RNA-based screening revealed that knockdown of ZNF764, which is located in the deleted segment unique to our case, significantly reduced glucocorticoid-, androgen-, and thyroid hormone-induced transcriptional activity of their responsive genes in HeLa cells, whereas its overexpression enhanced their transcriptional activity. The activities of the estrogen and progesterone receptors, cAMP response element-binding protein, and p53 were not affected in these cells. ZNF764 (zinc finger protein 764) expression was reduced in the patient's peripheral blood mononuclear cells, whereas exogenously supplemented ZNF764 recovered responsiveness to glucocorticoids in the patient's Epstein-Barr virus-transformed lymphocytes. The effect of ZNF764 on the glucocorticoid receptor transcriptional activity was mediated through cooperation with a general nuclear hormone receptor coactivator, transcriptional intermediary factor 1.
Conclusions: ZNF764 haploinsufficiency caused by microdeletion may be responsible for the partial multiple hormone resistance observed in our patient. ZNF764 appears to be involved in glucocorticoid, androgen, and thyroid hormone action. (J Clin Endocrinol Metab 97: E1557-E1566, 2012)
C1 [Kino, Tomoshige] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Unit Mol Hormone Act, Program Reprod & Adult Endocrinol, Clin Res Ctr,NIH, Bethesda, MD 20892 USA.
[Moraitis, Andreas G.] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Sect Reprod Endocrinol, Program Reprod & Adult Endocrinol, NIH, Bethesda, MD 20892 USA.
[Moraitis, Andreas G.; Raygada, Margarita; Stratakis, Constantine A.] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Sect Endocrinol & Genet, Program Dev Endocrinol & Genet, NIH, Bethesda, MD 20892 USA.
[Nemery, Robin L.] Joe DiMaggio Childrens Hosp, Dept Pediat Endocrinol, Hollywood, FL 33021 USA.
RP Kino, T (reprint author), Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Unit Mol Hormone Act, Program Reprod & Adult Endocrinol, Clin Res Ctr,NIH, Bldg 10,Room 1E-3140,10 Ctr Dr MSC 1109, Bethesda, MD 20892 USA.
EM kinot@mail.nih.gov
FU Eunice Kennedy Shriver National Institute of Child Health and Human
Development, National Institutes of Health
FX This study was funded by the Intramural Research Program of the Eunice
Kennedy Shriver National Institute of Child Health and Human
Development, National Institutes of Health.
CR Abrink M, 2001, P NATL ACAD SCI USA, V98, P1422, DOI 10.1073/pnas.041616998
Almeida MQ, 2011, J CLIN ENDOCR METAB, V96, pE728, DOI 10.1210/jc.2010-2420
Bachmann-Gagescu R, 2010, GENET MED, V12, P641, DOI 10.1097/GIM.0b013e3181ef4286
Bijlsma EK, 2009, EUR J MED GENET, V52, P77, DOI 10.1016/j.ejmg.2009.03.006
Bolton EC, 2007, GENE DEV, V21, P2005, DOI 10.1101/gad.1564207
Chrousos GP, 1999, J CLIN ENDOCR METAB, V84, P4450, DOI 10.1210/jc.84.12.4450
Collins T, 2001, MOL CELL BIOL, V21, P3609, DOI 10.1128/MCB.21.11.3609-3615.2001
De Bosscher K, 2009, MOL ENDOCRINOL, V23, P281, DOI 10.1210/me.2008-0283
Emerson RO, 2009, PLOS GENET, V5, DOI 10.1371/journal.pgen.1000325
Griffin JE, 1998, WILLIAMS TXB ENDOCRI, P799
Horvath A, 2006, NAT GENET, V38, P794, DOI 10.1038/ng1809
Jacquemont S, 2011, NATURE, V478, P97, DOI 10.1038/nature10406
Kikuchi M, 2009, BBA-MOL CELL RES, V1793, P1828, DOI 10.1016/j.bbamcr.2009.11.001
Kino T, 2010, SCI SIGNAL, V3, DOI 10.1126/scisignal.2000568
Kino T, 1999, J EXP MED, V189, P51, DOI 10.1084/jem.189.1.51
Kino T, 2005, J CELL BIOL, V169, P885, DOI 10.1083/jcb.200409150
Kovacs WJ, 1998, WILLIAMS TXB ENDOCRI, P517
Larsen PR, 1998, WILLIAMS TXB ENDOCRI, P357
LeDouarin B, 1996, EMBO J, V15, P6701
LeDouarin B, 1997, BIOCHEM SOC T, V25, P605
Lupski JR, 2005, PLOS GENET, V1, P627, DOI 10.1371/journal.pgen.0010049
McCarthy SE, 2009, NAT GENET, V41, P1223, DOI 10.1038/ng.474
McKenna NJ, 1999, ENDOCR REV, V20, P321, DOI 10.1210/er.20.3.321
New MI, 1999, J CLIN ENDOCR METAB, V84, P4454, DOI 10.1210/jc.84.12.4454
Nielsen AL, 1999, EMBO J, V18, P6385, DOI 10.1093/emboj/18.22.6385
Shinawi M, 2010, J MED GENET, V47, P332, DOI 10.1136/jmg.2009.073015
Slavotinek AM, 2008, HUM GENET, V124, P1, DOI 10.1007/s00439-008-0513-9
Weiss LA, 2008, NEW ENGL J MED, V358, P667, DOI 10.1056/NEJMoa075974
Yen PM, 2001, PHYSIOL REV, V81, P1097
NR 29
TC 4
Z9 4
PU ENDOCRINE SOC
PI CHEVY CHASE
PA 8401 CONNECTICUT AVE, SUITE 900, CHEVY CHASE, MD 20815-5817 USA
SN 0021-972X
EI 1945-7197
J9 J CLIN ENDOCR METAB
JI J. Clin. Endocrinol. Metab.
PD AUG
PY 2012
VL 97
IS 8
BP E1557
EP E1566
DI 10.1210/jc.2011-3493
PG 10
WC Endocrinology & Metabolism
SC Endocrinology & Metabolism
GA 987ZI
UT WOS:000307457400026
PM 22577170
ER
PT J
AU Cassileth, BR
Yarett, IR
AF Cassileth, Barrie R.
Yarett, Ian R.
TI Cancer Quackery: The Persistent Popularity of Useless, Irrational
'Alternative' Treatments
SO ONCOLOGY-NEW YORK
LA English
DT Article
ID SHARK CARTILAGE; CARCINOGENESIS; MEDICINE; AE-941; TRIAL; MODEL
AB At a time when many readily believe that vaccines cause autism, or that government scientists created AIDS as a weapon of black genocide, it is not surprising that medical quackery, especially cancer quackery, remains a flourishing and lucrative business throughout the developed world. This review provides a brief recap of its history and an overview of the various types of unproven or disproved cancer therapies popular now in the United States and elsewhere.
C1 [Cassileth, Barrie R.; Yarett, Ian R.] Mem Sloan Kettering Canc Ctr, Integrat Med Serv, New York, NY 10021 USA.
RP Cassileth, BR (reprint author), Mem Sloan Kettering Canc Ctr, Integrat Med Serv, 1429 1st Ave, New York, NY 10021 USA.
EM cassileth@MSKCC.org
CR American Cancer Society, 2008, OX THER
American Cancer Society, 1994, CA-CANCER J CLIN, V44, P115
American Cancer Society, 2008, SHARK CART
American Cancer Society, 1993, CA-CANCER J CLIN, V43, P57
Barber R, 2001, ANTICANCER RES, V21, P1065
Barrett S, 2010, QUESTIONABLE CANC TH
Barrett S, 2009, SOME NOTES QUANTUM X
Barrett S, 2004, BIORESONANCE TUMOR T
Cassileth B, 2011, ONCOLOGY-NY, V25, P1098
Cassileth BR, 2004, ONCOLOGIST, V9, P80, DOI 10.1634/theoncologist.9-1-80
CASSILETH BR, 1986, CANCER INVEST, V4, P591, DOI 10.3109/07357908609039837
Cassileth B R, 1982, N Engl J Med, V306, P1482, DOI 10.1056/NEJM198206173062410
CASSILETH BR, 1984, ANN INTERN MED, V101, P105
Federal Trade Commission, 2000, OP CUR ALL NETS SHAR
Gorski D, 2009, IRON ROLE CANC DANGE
Grossgebauer K, 1995, MED HYPOTHESES, V45, P545, DOI 10.1016/0306-9877(95)90238-4
LERNER IJ, 1992, CA-CANCER J CLIN, V42, P181, DOI 10.3322/canjclin.42.3.181
LERNER IJ, 1981, CA-CANCER J CLIN, V31, P91, DOI 10.3322/canjclin.31.2.91
Loprinzi CL, 2005, CANCER, V104, P176, DOI 10.1002/cncr.21107
Lu C, 2010, J NATL CANCER I, V102, P859, DOI 10.1093/jnci/djq179
Markolin C, 2009, GERMAN NEW MED
Ramsden D, 4 LEV EN HEAL TRAIN
Regumed, BICOM 2000 EAS CONV
Roberts L, 2009, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD000368.pub3
Sheu JR, 1998, ANTICANCER RES, V18, P4435
Tamayo C, 2000, PHYTOTHER RES, V14, P1, DOI 10.1002/(SICI)1099-1573(200002)14:1<1::AID-PTR580>3.3.CO;2-F
Ulbricht Catherine, 2009, J Soc Integr Oncol, V7, P73
Vickers AJ, 2006, J CLIN ONCOL, V24, P136, DOI 10.1200/JCO.2005.03.8406
Watt Barbara E, 2004, Toxicol Rev, V23, P51, DOI 10.2165/00139709-200423010-00006
Weber MH, 2002, INT J ONCOL, V20, P299
NR 30
TC 3
Z9 3
PU UBM MEDICA
PI NORWALK
PA 535 CONNECTICUT AVE, STE 300, NORWALK, CT 06854 USA
SN 0890-9091
J9 ONCOLOGY-NY
JI Oncology-NY
PD AUG
PY 2012
VL 26
IS 8
BP 754
EP 758
PG 5
WC Oncology
SC Oncology
GA 994EO
UT WOS:000307913900010
PM 22957409
ER
PT J
AU Frassinetti, F
Gessaroli, E
Santelli, E
di Pellegrino, G
AF Frassinetti, Francesca
Gessaroli, Erica
Santelli, Erica
di Pellegrino, Giuseppe
TI Interpersonal space in autism spectrum disorders
SO COGNITIVE PROCESSING
LA English
DT Meeting Abstract
C1 [Frassinetti, Francesca; Gessaroli, Erica] Ist Sci Castel Goffredo, IRCCS, Clin Lavoro & Riabilitaz, Fdn Salvatore Maugeri, Mantua, Italy.
[Frassinetti, Francesca; Gessaroli, Erica; di Pellegrino, Giuseppe] Univ Bologna, Dept Psychol, I-40126 Bologna, Italy.
[Santelli, Erica] Ctr Autismo, Reggio Emilia, Italy.
NR 0
TC 0
Z9 0
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1612-4782
J9 COGN PROCESS
JI Cogn. Process.
PD AUG
PY 2012
VL 13
SU 1
SI SI
BP S18
EP S19
PG 2
WC Psychology, Experimental
SC Psychology
GA 006NA
UT WOS:000308824700065
ER
PT J
AU Louis, P
AF Louis, Petra
TI Does the Human Gut Microbiota Contribute to the Etiology of Autism
Spectrum Disorders?
SO DIGESTIVE DISEASES AND SCIENCES
LA English
DT Editorial Material
ID CHILDREN; MICROFLORA; METABOLISM; FECES
C1 Univ Aberdeen, Rowett Inst Nutr & Hlth, Aberdeen AB21 9SB, Scotland.
RP Louis, P (reprint author), Univ Aberdeen, Rowett Inst Nutr & Hlth, Greenburn Rd, Aberdeen AB21 9SB, Scotland.
EM p.louis@abdn.ac.uk
CR Adams JB, 2011, BMC GASTROENTEROL, V11, DOI 10.1186/1471-230X-11-22
Amaral DG, 2011, BRAIN RES, V1380, P3, DOI 10.1016/j.brainres.2010.11.077
Benach JL, 2012, MBIO, V3, P1, DOI 10.3391/mbi.2012.3.1.01
Bienenstock J, 2010, CLIN EXP IMMUNOL, V160, P85, DOI 10.1111/j.1365-2249.2010.04124.x
Clayton TA, 2012, FEBS LETT, V586, P956, DOI 10.1016/j.febslet.2012.01.049
Critchfield JW, 2011, GASTROENT RES PRACT, DOI 10.1155/2011/161358
Dietert Rodney R, 2011, Emerg Health Threats J, V4, P7111, DOI 10.3402/ehtj.v4i0.7111
Finegold SM, 2002, CLIN INFECT DIS, V35, pS6, DOI 10.1086/341914
Finegold SM, 2010, ANAEROBE, V16, P444, DOI 10.1016/j.anaerobe.2010.06.008
Louis P, 2007, J APPL MICROBIOL, V102, P1197, DOI 10.1111/j.1365-2672.2007.03322.x
Onore C, 2012, BRAIN BEHAV IMMUN, V26, P383, DOI 10.1016/j.bbi.2011.08.007
Parracho HMRT, 2005, J MED MICROBIOL, V54, P987, DOI 10.1099/jmm.0.46101-0
Sekirov I, 2010, PHYSIOL REV, V90, P859, DOI 10.1152/physrev.00045.2009
Song YL, 2004, APPL ENVIRON MICROB, V70, P6459, DOI 10.1128/AEM.70.11.6459-6465.2004
Wang L, 2012, DIGEST DIS SCI, V57, P2096, DOI 10.1007/s10620-012-2167-7
Wang L, 2011, APPL ENVIRON MICROB, V77, P6718, DOI 10.1128/AEM.05212-11
Williams BL, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0024585
Williams BL, 2012, MBIO, V3, P1
NR 18
TC 22
Z9 22
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0163-2116
J9 DIGEST DIS SCI
JI Dig. Dis. Sci.
PD AUG
PY 2012
VL 57
IS 8
BP 1987
EP 1989
DI 10.1007/s10620-012-2286-1
PG 3
WC Gastroenterology & Hepatology
SC Gastroenterology & Hepatology
GA 980YM
UT WOS:000306930100004
PM 22736019
ER
PT J
AU Wang, L
Christophersen, CT
Sorich, MJ
Gerber, JP
Angley, MT
Conlon, MA
AF Wang, Lv
Christophersen, Claus Thagaard
Sorich, Michael Joseph
Gerber, Jacobus Petrus
Angley, Manya Therese
Conlon, Michael Allan
TI Elevated Fecal Short Chain Fatty Acid and Ammonia Concentrations in
Children with Autism Spectrum Disorder
SO DIGESTIVE DISEASES AND SCIENCES
LA English
DT Article
DE Autism spectrum disorder; Short chain fatty acids; Phenols; Ammonia
ID RESISTANT STARCH; P-CRESOL; INDIVIDUALS; MICROBIOTA; FERMENTATION;
METABOLISM; SYMPTOMS; DISEASE; PHENOL; HEALTH
AB Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder where a high frequency of gastrointestinal disturbance (e.g., constipation and diarrhea) is reported. As large bowel fermentation products can have beneficial or detrimental effects on health, these were measured in feces of children with and without ASD to examine whether there is an underlying disturbance in fermentation processes in the disorder.
Fecal samples (48 h) were collected from children with ASD (n = 23), and without ASD (n = 31) of similar age. Concentrations of short chain fatty acids, phenols and ammonia were measured.
Fecal total short chain fatty acid concentrations were significantly higher in children with ASD compared to controls (136.6 +/- A 8.7 vs. 111.1 +/- A 6.6 mmol/kg). Moreover, when concentrations of fecal acetic, butyric, isobutyric, valeric, isovaleric and caproic acids were measured, all were significantly higher in children with ASD compared with controls except for caproic acid. The concentration of fecal ammonia was also significantly greater in ASD participants than controls (42.7 +/- A 3.3 vs. 32.3 +/- A 1.9 mmol/kg). Fecal phenol levels and pH did not differ between groups. Macronutrient intake, as determined from dietary records kept by caregivers, also did not differ significantly between study groups.
Our results suggest fermentation processes or utilization of fermentation products may be altered in children with ASD compared to children without ASD.
C1 [Wang, Lv; Sorich, Michael Joseph; Gerber, Jacobus Petrus; Angley, Manya Therese] Univ S Australia, Sansom Inst Hlth Res, Adelaide, SA 5001, Australia.
[Christophersen, Claus Thagaard; Conlon, Michael Allan] CSIRO Food & Nutr Sci, Preventat Hlth Natl Res Flagship, Adelaide, SA 5001, Australia.
RP Angley, MT (reprint author), Univ S Australia, Sansom Inst Hlth Res, GPO Box 2471, Adelaide, SA 5001, Australia.
EM wanly049@mymail.unisa.edu.au; C.Christophersen@csiro.au;
michael.sorich@unisa.edu.au; cobus.gerber@unisa.edu.au;
manya.angley@unisa.edu.au; michael.conlon@csiro.au
RI Sorich, Michael/A-1210-2011; Christophersen, Claus/C-5512-2008; Conlon,
Michael/H-6769-2013; Gerber, Jacobus/F-4423-2013
OI Sorich, Michael/0000-0003-1999-866X; Christophersen,
Claus/0000-0003-1591-5871;
FU Australian Rotary Health Research Fund
FX This research was funded by The Australian Rotary Health Research Fund.
We wish to express our gratitude to the participating children and their
parents. We would also like to acknowledge Dr Richard Couper, pediatric
gastroenterologist, for medical advice; Mrs. Rosalind Miller for
statistical assistance; and Emma Watson, Ben Scherer, Bruce May and Rhys
Bushell for technical assistance.
CR Adams JB, 2011, BMC GASTROENTEROL, V11, DOI 10.1186/1471-230X-11-22
Altieri L, 2011, BIOMARKERS, V16, P9
Bird AR, 2010, BENEF MICROBES, V1, P423, DOI 10.3920/BM2010.0041
Birkett AM, 1997, EUR J CLIN NUTR, V51, P625, DOI 10.1038/sj.ejcn.1600456
Buie T, 2010, PEDIATRICS, V125, pS1, DOI 10.1542/peds.2009-1878C
Campbell DB, 2009, PEDIATRICS, V123, P1018, DOI 10.1542/peds.2008-0819
CHANEY AL, 1962, CLIN CHEM, V8, P130
Clark-Taylor T, 2004, MED HYPOTHESES, V62, P970, DOI 10.1016/j.mehy.2004.01.011
Clayton TA, 2009, P NATL ACAD SCI USA, V106, P14728, DOI 10.1073/pnas.0904489106
de Magistris L, 2010, J PEDIATR GASTR NUTR, V51, P418, DOI 10.1097/MPG.0b013e3181dcc4a5
DEufemia P, 1996, ACTA PAEDIATR, V85, P1076, DOI 10.1111/j.1651-2227.1996.tb14220.x
Eapen V, 2011, CURR OPIN PSYCHIATR, V24, P226, DOI 10.1097/YCO.0b013e328345927e
Felipo V, 2002, PROG NEUROBIOL, V67, P259, DOI 10.1016/S0301-0082(02)00019-9
Filipek PA, 2004, J AUTISM DEV DISORD, V34, P615, DOI 10.1007/s10803-004-5283-1
Finegold SM, 2010, ANAEROBE, V16, P444, DOI 10.1016/j.anaerobe.2010.06.008
Franklin A.E., 2008, AM J BIOCH BIOTECHNO, V4, P146
Fukuda S, 2011, NATURE, V469, P543, DOI 10.1038/nature09646
Hopkins MJ, 2002, DIGEST LIVER DIS, V34, pS12, DOI 10.1016/S1590-8658(02)80157-8
Kau AL, 2011, NATURE, V474, P327, DOI 10.1038/nature10213
King RA, 2009, ANAL BIOCHEM, V384, P27, DOI 10.1016/j.ab.2008.09.034
MacFabe DF, 2007, BEHAV BRAIN RES, V176, P149, DOI 10.1016/j.bbr.2006.07.025
Maslowski KM, 2009, NATURE, V461, P1282, DOI 10.1038/nature08530
McOrist AL, 2011, J NUTR, V141, P883, DOI 10.3945/jn.110.128504
McOrist AL, 2008, BRIT J NUTR, V100, P138, DOI 10.1017/S0007114507886351
Meletis C. D., 2008, Alternative and Complementary Therapies, V14, P132, DOI 10.1089/act.2008.14305
Messahel S, 1998, NEUROSCI LETT, V241, P17, DOI 10.1016/S0304-3940(97)00976-2
Nowak A, 2006, ANAEROBE, V12, P80, DOI 10.1016/j.anaerobe.2005.10.003
Smith RA, 2009, AUTISM, V13, P343, DOI 10.1177/1362361309106418
Tjellstrom B, 2005, AM J GASTROENTEROL, V100, P2784, DOI 10.1111/j.1572-0241.2005.00313.x
Topping DL, 2001, PHYSIOL REV, V81, P1031
Van Nuenen MHMC, 2004, DIGEST DIS SCI, V49, P485, DOI 10.1023/B:DDAS.0000020508.64440.73
Wang L, 2011, APPL ENVIRON MICROB, V77, P6718, DOI 10.1128/AEM.05212-11
Wang L, 2009, BIOMARKERS, V14, P596, DOI 10.3109/13547500903183962
Whiteley P, 2010, AUTISM INSIGHTS, V2, P17
Williams BL, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0024585
Wong JMW, 2006, J CLIN GASTROENTEROL, V40, P235, DOI 10.1097/00004836-200603000-00015
Yap IKS, 2010, J PROTEOME RES, V9, P2996, DOI 10.1021/pr901188e
NR 37
TC 24
Z9 25
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0163-2116
J9 DIGEST DIS SCI
JI Dig. Dis. Sci.
PD AUG
PY 2012
VL 57
IS 8
BP 2096
EP 2102
DI 10.1007/s10620-012-2167-7
PG 7
WC Gastroenterology & Hepatology
SC Gastroenterology & Hepatology
GA 980YM
UT WOS:000306930100018
PM 22535281
ER
PT J
AU Gordon, AG
AF Gordon, A. G.
TI Audiovestibular deficits in Duchenne muscular dystrophy
SO BRITISH JOURNAL OF OCCUPATIONAL THERAPY
LA English
DT Letter
ID AUTISM; CHILDREN
EM aggordon2003@yahoo.co.uk
CR Adamson A, 2006, BRIT J OCCUPATIONAL, V69, P357
American Psychiatric Association, 2000, DIAGN STAT MAN MENT
Backhouse M, 2012, BRIT J OCCUP THER, V75, P271, DOI 10.4276/030802212X1338370345148
Bolton PF, 2012, J AM ACAD CHILD PSY, V51, P249, DOI 10.1016/j.jaac.2011.12.009
Ciafaloni E, 2009, J PEDIATR-US, V155, P380, DOI 10.1016/j.jpeds.2009.02.007
GORDON A G, 1986, British Journal of Audiology, V20, P95, DOI 10.3109/03005368609079002
Gordon AG, 2009, BRAIN, V132, DOI 10.1093/brain/awp188
Gordon AG, 2008, BRIT J DEV DISABIL, V54, P55
Roth DAE, 2012, DEV MED CHILD NEUROL, V54, P23, DOI 10.1111/j.1469-8749.2011.04149.x
Sarig R, 1999, HUM MOL GENET, V8, P1, DOI 10.1093/hmg/8.1.1
NR 10
TC 0
Z9 0
PU COLL OCCUPATIONAL THERAPISTS LTD
PI SOUTHWARK
PA 106-114 BOROUGH HIGH ST, SOUTHWARK, LONDON SE1 1LB, ENGLAND
SN 0308-0226
J9 BRIT J OCCUP THER
JI Br. J. Occup. Ther.
PD AUG
PY 2012
VL 75
IS 8
BP 393
EP 393
PG 1
WC Rehabilitation
SC Rehabilitation
GA 994CU
UT WOS:000307909300008
ER
PT J
AU Southard, AE
Edelmann, LJ
Gelb, BD
AF Southard, Abigail E.
Edelmann, Lisa J.
Gelb, Bruce D.
TI Role of Copy Number Variants in Structural Birth Defects
SO OBSTETRICAL & GYNECOLOGICAL SURVEY
LA English
DT Editorial Material
AB The Human Genome Project led to the discovery that the genome contains multiple regions of DNA gains and losses called copy number variants (CNVs). Benign CNVs not associated with phenotypic anomalies account for a significant proportion of the healthy human genome. However, larger CNVs, often de novo, are pathogenic and have been increasingly recognized as being associated with human disease. Advances in genetic testing have made it possible to identify previously unknown genotypic aberrations among specific CNVs that can be correlated with birth defects, developmental problems, and other phenotypic anomalies. New genetic tests such as array comparative genomic hybridization (CGH) and single nucleotide polymorphism arrays show a clear diagnostic benefit over conventional G-banding karyotypes for patients with autism spectrum disorder, nonsyndromic developmental delay, and multiple congenital anomalies. However, the value of these tests to identify pathogenic CNVs in isolated structural birth defects is unknown.
The aim of this study was to document the relationship between specific CNVs and isolated structural abnormalities of the craniofacial, renal, respiratory, and cardiac systems. A nonsystematic review of the literature was conducted using the PubMed database through May 2011 to identify full-length articles published in English. Search terms included CNVs, array CGH, birth defects, and isolated structural defects of the craniofacial, respiratory, renal, and cardiac systems.
The review found evidence that putatively pathogenic CNVs occur more frequently in patients with isolated structural birth defects than in the general population. Specific regions of the genome were often implicated.
These findings show significant progress in identifying genes and specific loci contributing to isolated structural birth defects through advances in CNV detection. Increasing knowledge of the role of CNVs in disease phenotypes may lead to improved patient care and genetic counseling and, eventually, may result in prenatal screening on a large scale for these and other birth defects.
C1 [Southard, Abigail E.] Mt Sinai Sch Med, Child Hlth & Dev Inst, Dept Genet, New York, NY USA.
Mt Sinai Sch Med, Child Hlth & Dev Inst, Dept Genom Sci, New York, NY USA.
RP Southard, AE (reprint author), Mt Sinai Sch Med, Child Hlth & Dev Inst, Dept Genet, New York, NY USA.
NR 0
TC 0
Z9 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0029-7828
J9 OBSTET GYNECOL SURV
JI Obstet. Gynecol. Surv.
PD AUG
PY 2012
VL 67
IS 8
BP 472
EP 473
DI 10.1097/01.ogx.0000419564.79750.3e
PG 2
WC Obstetrics & Gynecology
SC Obstetrics & Gynecology
GA 005LG
UT WOS:000308751300010
ER
PT J
AU Liemburg, EJ
Swart, M
Bruggeman, R
Kortekaas, R
Knegtering, H
Curcic-Blake, B
Aleman, A
AF Liemburg, Edith J.
Swart, Marte
Bruggeman, Richard
Kortekaas, Rudie
Knegtering, Henderikus
Curcic-Blake, Branislava
Aleman, Andre
TI Altered resting state connectivity of the default mode network in
alexithymia
SO SOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCE
LA English
DT Article
DE alexithymia; connectivity; default mode network; fMRI; resting state
ID AUTISM SPECTRUM DISORDER; FUNCTIONAL CONNECTIVITY; EMOTION REGULATION;
AMYGDALA ACTIVITY; CINGULATE CORTEX; NEGATIVE EMOTION; BRAIN-FUNCTION;
FMRI; FEELINGS; SELF
AB Alexithymia is a trait characterized by a diminished capacity to describe and distinguish emotions and to fantasize; it is associated with reduced introspection and problems in emotion processing. The default mode network (DMN) is a network of brain areas that is normally active during rest and involved in emotion processing and self-referential mental activity, including introspection. We hypothesized that connectivity of the DMN might be altered in alexithymia. Twenty alexithymic and 18 non-alexithymic healthy volunteers underwent a resting state fMRI scan. Independent component analysis was used to identify the DMN. Differences in connectivity strength were compared between groups. Within the DMN, alexithymic participants showed lower connectivity within areas of the DMN (medial frontal and temporal areas) as compared to non-alexithymic participants. In contrast, connectivity in the high-alexithymic participants was higher for the sensorimotor cortex, occipital areas and right lateral frontal cortex than in the low-alexithymic participants. These results suggest a diminished connectivity within the DMN of alexithymic participants, in brain areas that may also be involved in emotional awareness and self-referential processing. On the other hand, alexithymia was associated with stronger functional connections of the DMN with brain areas involved in sensory input and control of emotion.
C1 [Liemburg, Edith J.; Swart, Marte; Kortekaas, Rudie; Curcic-Blake, Branislava; Aleman, Andre] Univ Groningen, Univ Med Ctr Groningen, Dept Neurosci, NL-9713 AW Groningen, Netherlands.
[Liemburg, Edith J.; Swart, Marte; Kortekaas, Rudie; Curcic-Blake, Branislava; Aleman, Andre] Univ Groningen, BCN NeuroImaging Ctr, NL-9713 AW Groningen, Netherlands.
[Swart, Marte; Knegtering, Henderikus; Aleman, Andre] Lentis, Ctr Mental Healthcare, NL-9725 AG Groningen, Netherlands.
[Bruggeman, Richard; Knegtering, Henderikus] Univ Med Ctr Groningen, Univ Ctr Psychiat, NL-9713 GZ Groningen, Netherlands.
Univ Groningen, Dept Psychol, NL-9712 TS Groningen, Netherlands.
RP Liemburg, EJ (reprint author), NeuroImaging Ctr, Antonius Deusinglaan 2, NL-9713 AW Groningen, Netherlands.
EM E.J.Liemburg@med.umcg.nl
FU EURopean Young Investigator award (N.W.O.) [044035001]
FX This work was supported by a EURopean Young Investigator award (N.W.O.
number 044035001) awarded to A.A.
CR Abler B, 2010, PSYCHIAT RES-NEUROIM, V183, P105, DOI 10.1016/j.pscychresns.2010.05.010
Aleman A, 2005, TRENDS COGN SCI, V9, P553, DOI 10.1016/j.tics.2005.10.002
Aleman A, 2005, CEREB CORTEX, V15, P221, DOI 10.1093/cercor/bhh124
Anderson JS, 2010, AM J NEURORADIOL, V31, P131, DOI 10.3174/ajnr.A1789
Assaf M, 2010, NEUROIMAGE, V53, P247, DOI 10.1016/j.neuroimage.2010.05.067
Auer DP, 2008, MAGN RESON IMAGING, V26, P1055, DOI 10.1016/j.mri.2008.05.008
Bermond B., 1993, BERMOND VORST ALEXIT
Berthoz S, 2007, J PSYCHOSOM RES, V62, P341, DOI 10.1016/j.jpsychores.2006.10.008
Berthoz S, 2005, EUR PSYCHIAT, V20, P291, DOI 10.1016/j.eurpsy.2004.06.013
Berthoz S, 2002, AM J PSYCHIAT, V159, P961, DOI 10.1176/appi.ajp.159.6.961
Berthoz S., 2000, EUR REV APPL PSYCHOL, V50, P359
Bluhm RL, 2008, NEUROREPORT, V19, P887, DOI 10.1097/WNR.0b013e328300ebbf
Borsci G., 2008, J AFFECT DISORDERS, V114, P208
Buckner RL, 2008, ANN NY ACAD SCI, V1124, P1, DOI 10.1196/annals.1440.011
Calhoun VD, 2001, HUM BRAIN MAPP, V14, P140, DOI 10.1002/hbm.1048
Damasio, 2003, ANN NY ACAD SCI, V1001, P253
Damoiseaux JS, 2006, P NATL ACAD SCI USA, V103, P13848, DOI 10.1073/pnas.0601417103
D'Argembeau A, 2005, NEUROIMAGE, V25, P616, DOI 10.1016/j.neuroimage.2004.11.048
Deborde AS, 2008, PSYCHOPATHOLOGY, V41, P43, DOI 10.1159/000109955
Fox MD, 2007, NAT REV NEUROSCI, V8, P700, DOI 10.1038/nrn2201
FOX PT, 1994, SCIENCE, V266, P994, DOI 10.1126/science.7973682
Fransson P, 2006, NEUROPSYCHOLOGIA, V44, P2836, DOI 10.1016/j.neuropsychologia.2006.06.017
Garrity AG, 2007, AM J PSYCHIAT, V164, P450, DOI 10.1176/appi.ajp.164.3.450
Goldin PR, 2008, BIOL PSYCHIAT, V63, P577, DOI 10.1016/j.biopsych.2007.05.031
Gusnard DA, 2001, NAT REV NEUROSCI, V2, P685, DOI 10.1038/35094500
Hasenkamp W, 2012, FRONT HUM NEUROSCI, V6, DOI 10.3389/fnhum.2012.00038
He Y., 2004, I ELECT ELECT ENG, V1, P980
Hesling I, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0011571
Himberg J, 2004, NEUROIMAGE, V22, P1214, DOI 10.1016/j.neuroimage.2004.03.027
Himberg J, 2003, 2003 IEEE XIII WORKSHOP ON NEURAL NETWORKS FOR SIGNAL PROCESSING - NNSP'03, P259, DOI 10.1109/NNSP.2003.1318025
Jafri MJ, 2008, NEUROIMAGE, V39, P1666, DOI 10.1016/j.neuroimage.2007.11.001
Kano M, 2003, BRAIN, V126, P1474, DOI 10.1093/brain/awg131
Karlsson H, 2008, BRIT J PSYCHIAT, V192, P32, DOI 10.1192/bjp.bp.106.034728
Kim H, 2010, NEUROIMAGE, V50, P1648, DOI 10.1016/j.neuroimage.2010.01.051
Kim SH, 2007, J COGNITIVE NEUROSCI, V19, P776, DOI 10.1162/jocn.2007.19.5.776
Kober H, 2008, NEUROIMAGE, V42, P998, DOI 10.1016/j.neuroimage.2008.03.059
Laird AR, 2009, J NEUROSCI, V29, P14496, DOI 10.1523/JNEUROSCI.4004-09.2009
Lane RD, 1997, BIOL PSYCHIAT, V42, P834, DOI 10.1016/S0006-3223(97)00050-4
Lane RD, 1998, J COGNITIVE NEUROSCI, V10, P525, DOI 10.1162/089892998562924
Li Y., 2006, P ISBI WASH DC
Lieberman MD, 2005, NAT NEUROSCI, V8, P720, DOI 10.1038/nn1465
Lieberman MD, 2007, PSYCHOL SCI, V18, P421, DOI 10.1111/j.1467-9280.2007.01916.x
Maldjian JA, 2003, NEUROIMAGE, V19, P1233, DOI 10.1016/S1053-8119(03)00169-1
Mantani T, 2005, BIOL PSYCHIAT, V57, P982, DOI 10.1016/j.biopsych.2005.01.047
Meltzer MA, 2010, CONSCIOUS COGN, V19, P1062, DOI 10.1016/j.concog.2010.05.008
Moriguchi Y, 2006, NEUROIMAGE, V32, P1472, DOI 10.1016/j.neuroimage.2006.04.186
Northoff G, 2006, NEUROIMAGE, V31, P440, DOI 10.1016/j.neuroimage.2005.12.002
Ochsner KN, 2002, J COGNITIVE NEUROSCI, V14, P1215, DOI 10.1162/089892902760807212
Phan KL, 2005, BIOL PSYCHIAT, V57, P210, DOI 10.1016/j.biopsych.2004.10.030
Raichle ME, 2001, P NATL ACAD SCI USA, V98, P676, DOI 10.1073/pnas.98.2.676
Raichle ME, 2005, J COMP NEUROL, V493, P167, DOI 10.1002/cne.20752
Reker M., 2009, CORTEX, V46, P658
Salminen JK, 1999, J PSYCHOSOM RES, V46, P75, DOI 10.1016/S0022-3999(98)00053-1
Sauvage L, 2006, PSYCHOL REP, V98, P234, DOI 10.2466/PRO.98.1.234-236
Schilbach L, 2008, CONSCIOUS COGN, V17, P457, DOI 10.1016/j.concog.2008.03.013
Shalom DB, 2009, NEUROSCIENTIST, V15, P589, DOI 10.1177/1073858409336371
SIFNEOS PE, 1973, PSYCHOTHER PSYCHOSOM, V21, P133
Silani G, 2008, SOC NEUROSCI, V3, P97, DOI 10.1080/17470910701577020
Singh KD, 2008, NEUROIMAGE, V41, P100, DOI 10.1016/j.neuroimage.2008.01.051
Smith SM, 2009, P NATL ACAD SCI USA, V106, P13040, DOI 10.1073/pnas.0905267106
Swart M, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0005751
Tavares P., 2010, SOCIAL COGNITIVE AFF, V6, P98
Taylor GJ, 1997, DISORDERS AFFECT REG
TAYLOR GJ, 1991, PSYCHOSOMATICS, V32, P153
Taylor GJ, 2000, CAN J PSYCHIAT, V45, P134
Urry HL, 2009, NEUROIMAGE, V47, P852, DOI 10.1016/j.neuroimage.2009.05.069
van de Ven VG, 2004, HUM BRAIN MAPP, V22, P165, DOI 10.1002/hbm.20022
van de Ven VG, 2005, NEUROIMAGE, V27, P644, DOI 10.1016/j.neuroimage.2005.04.041
van Rijn S, 2011, PSYCHIAT RES, V187, P100, DOI 10.1016/j.psychres.2010.10.007
van 't Wout M, 2007, COMPR PSYCHIAT, V48, P27, DOI 10.1016/j.comppsych.2006.07.003
Wager TD, 2008, NEURON, V59, P1037, DOI 10.1016/j.neuron.2008.09.006
Waller E, 2006, INT REV PSYCHIATR, V18, P13, DOI 10.1080/09540260500466774
WATSON D, 1988, J PERS SOC PSYCHOL, V54, P1063, DOI 10.1037/0022-3514.54.6.1063
Zech E, 1999, EUR J PERSONALITY, V13, P511
NR 74
TC 4
Z9 4
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1749-5016
J9 SOC COGN AFFECT NEUR
JI Soc. Cogn. Affect. Neurosci.
PD AUG
PY 2012
VL 7
IS 6
BP 660
EP 666
DI 10.1093/scan/nss048
PG 7
WC Neurosciences; Psychology; Psychology, Experimental
SC Neurosciences & Neurology; Psychology
GA 998JH
UT WOS:000308233400005
PM 22563009
ER
PT J
AU van Rijn, S
Swaab, H
Baas, D
de Haan, E
Kahn, RS
Aleman, A
AF van Rijn, Sophie
Swaab, Hanna
Baas, Daan
de Haan, Edward
Kahn, Rene S.
Aleman, Andre
TI Neural systems for social cognition in Klinefelter syndrome (47,XXY):
evidence from fMRI
SO SOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCE
LA English
DT Article
DE X chromosome; social cognition; autism; schizophrenia; amygdala;
Klinefelter
ID OF-THE-LITERATURE; SEX-DIFFERENCES; HUMAN AMYGDALA; TESTOSTERONE LEVELS;
FACE PERCEPTION; AUTISM; BRAIN; XXY; SCHIZOPHRENIA; CHROMOSOME
AB Klinefelter syndrome (KS) is a chromosomal condition (47, XXY) that may help us to unravel gene-brain behavior pathways to psychopathology. The phenotype includes social cognitive impairments and increased risk for autism traits. We used functional MRI to study neural mechanisms underlying social information processing. Eighteen nonclinical controls and thirteen men with XXY were scanned during judgments of faces with regard to trustworthiness and age. While judging faces as untrustworthy in comparison to trustworthy, men with XXY displayed less activation than controls in (i) the amygdala, which plays a key role in screening information for socio-emotional significance, (ii) the insula, which plays a role in subjective emotional experience, as well as (iii) the fusiform gyrus and (iv) the superior temporal sulcus, which are both involved in the perceptual processing of faces and which were also less involved during age judgments in men with XXY. This is the first study showing that KS can be associated with reduced involvement of the neural network subserving social cognition. Studying KS may increase our understanding of the genetic and hormonal basis of neural dysfunctions contributing to abnormalities in social cognition and behavior, which are considered core abnormalities in psychiatric disorders such as autism and schizophrenia.
C1 [van Rijn, Sophie] Leiden Univ, Fac Social Sci Clin Child & Adolescent Studies, NL-2333 AK Leiden, Netherlands.
[van Rijn, Sophie; Swaab, Hanna] Leiden Inst Brain & Cognit, NL-2333 ZA Leiden, Netherlands.
[Baas, Daan] Univ Utrecht, Helmholtz Inst, Dept Expt Psychol, NL-3584 CS Utrecht, Netherlands.
[Baas, Daan; Kahn, Rene S.] Univ Med Ctr Utrecht, Rudolf Magnus Inst Neurosci, Dept Psychiat, NL-3584 CX Utrecht, Netherlands.
[de Haan, Edward] Univ Amsterdam, Dept Psychol, NL-1018 WB Amsterdam, Netherlands.
[Aleman, Andre] Univ Groningen, Univ Med Ctr Groningen, BCN NeuroImaging Ctr, NL-9713 AW Groningen, Netherlands.
RP van Rijn, S (reprint author), Leiden Univ, Fac Social Sci Clin Child & Adolescent Studies, Wassenaarseweg 52, NL-2333 AK Leiden, Netherlands.
EM srijn@fsw.leidenuniv.nl
FU Netherlands Organization for Scientific Research (NWO) [016.026.027,
016.095.060]
FX This work was supported by a VernieuwingsImpuls grant [016.026.027 to
A.A.] and a Veni grant [016.095.060 to S.v.R.] from the Netherlands
Organization for Scientific Research (NWO).
CR Abdi Z, 2004, CNS SPECTRUMS, V9, P335
Adolphs R, 2001, CURR OPIN NEUROBIOL, V11, P231, DOI 10.1016/S0959-4388(00)00202-6
Adolphs R, 1998, NATURE, V393, P470, DOI 10.1038/30982
Aksglaede L, 2007, EUR J ENDOCRINOL, V157, P345, DOI 10.1530/EJE-07-0310
Aksglaede L, 2008, J CLIN ENDOCR METAB, V93, P169, DOI 10.1210/jc.2007-1426
Amaral DG, 2003, ANN NY ACAD SCI, V1000, P337, DOI 10.1196/annanls.1280.015
Baas D, 2008, NEUROIMAGE, V40, P719, DOI 10.1016/j.neuroimage.2007.12.039
Baron-Cohen S, 2005, SCIENCE, V310, P819, DOI 10.1126/science.1115455
Baron-Cohen S, 2001, J AUTISM DEV DISORD, V31, P5, DOI 10.1023/A:1005653411471
Beauchamp MH, 2010, PSYCHOL BULL, V136, P39, DOI 10.1037/a0017768
Bishop D.V., ARCH DIS CH IN PRESS
Boada R, 2009, DEV DISABIL RES REV, V15, P284, DOI 10.1002/ddrr.83
Bojesen A, 2006, J CLIN ENDOCR METAB, V91, P1254, DOI 10.1210/jc.2005-0697
Boks MPM, 2007, SCHIZOPHR RES, V93, P399, DOI 10.1016/j.schres.2007.03.015
Boone KB, 2001, J INT NEUROPSYCH SOC, V7, P446, DOI 10.1017/S1355617701744013
Brody N, 1992, WESCHLER ADULT INTEL
Bruining H, 2009, PEDIATRICS, V123, pE865, DOI 10.1542/peds.2008-1954
Corrigan P., 2001, SOCIAL COGNITION SCH
Craig IW, 2004, ANN HUM GENET, V68, P269, DOI 10.1046/j.1529-8817.2004.00098.x
DeLisi LE, 2005, AM J MED GENET B, V135B, P15, DOI 10.1002/ajmg.b.30163
FEIN D, 1986, J AM ACAD CHILD PSY, V25, P198, DOI 10.1016/S0002-7138(09)60227-2
Geschwind D.H., 2004, LEARNING DISABILITIE, V19, P166, DOI 10.1111/j.1540-5826.2004.00100.x
Geschwind DH, 2000, MENT RETARD DEV D R, V6, P107, DOI 10.1002/1098-2779(2000)6:2<107::AID-MRDD4>3.0.CO;2-2
Giedd JN, 2007, PEDIATRICS, V119, pE232, DOI 10.1542/peds.2005-2969
Grill-Spector K, 2004, NAT NEUROSCI, V7, P555, DOI 10.1038/nn1224
Haxby JV, 2000, TRENDS COGN SCI, V4, P223, DOI 10.1016/S1364-6613(00)01482-0
Haxby JV, 2002, BIOL PSYCHIAT, V51, P59, DOI 10.1016/S0006-3223(01)01330-0
Iarocci G, 2007, BRAIN COGNITION, V65, P112, DOI 10.1016/j.bandc.2007.01.008
Maldjian JA, 2003, NEUROIMAGE, V19, P1233, DOI 10.1016/S1053-8119(03)00169-1
Morris JS, 1998, BRAIN, V121, P47, DOI 10.1093/brain/121.1.47
Patwardhan AJ, 2002, AM J MED GENET, V114, P93, DOI 10.1002/ajmg.10154
Phan KL, 2002, NEUROIMAGE, V16, P331, DOI 10.1006/nimg.2002.1087
Phelps EA, 2006, ANNU REV PSYCHOL, V57, P27, DOI 10.1146/annurev.psych.56.091103.070234
PICS, PSYCH IM COLL STIRL
Pinkham AE, 2008, SCHIZOPHR RES, V99, P164, DOI 10.1016/j.schres.2007.10.024
Puce A, 1996, J NEUROSCI, V16, P5205
Ratcliffe S, 1999, ARCH DIS CHILD, V80, P192
RATCLIFFE SG, 1994, HORM RES, V42, P106, DOI 10.1159/000184157
Ross JL, 2005, HORM RES, V64, P39, DOI 10.1159/000087313
SALBENBLATT JA, 1985, PEDIATR RES, V19, P82, DOI 10.1203/00006450-198501000-00022
Samango-Sprouse C, 2001, SEMIN REPROD MED, V19, P193, DOI 10.1055/s-2001-15400
Sheehan DV, 1998, J CLIN PSYCHIAT, V59, P22, DOI 10.4088/JCP.09m05305whi
Shen DG, 2004, NEUROIMAGE, V23, P648, DOI 10.1016/j.neuroimage.2004.08.018
SIMERLY RB, 1990, J COMP NEUROL, V294, P76, DOI 10.1002/cne.902940107
Simm PJ, 2006, J PEDIATR ENDOCR MET, V19, P499
Skuse DH, 2000, PEDIATR RES, V47, P9, DOI 10.1203/00006450-200001000-00006
Steinman K, 2009, DEV DISABIL RES REV, V15, P295, DOI 10.1002/ddrr.84
van Rijn S, 2007, J INT NEUROPSYCH SOC, V13, P1065, DOI 10.1017/S1355617707071044
Van Rijn S, 2006, BRIT J PSYCHIAT, V189, P459, DOI 10.1192/bjp.bp.105.008961
van Rijn S, 2006, SCHIZOPHR RES, V84, P194, DOI 10.1016/j.schres.2006.02.020
van Rijn S, 2008, J AUTISM DEV DISORD, V38, P1634, DOI 10.1007/s10803-008-0542-1
Visootsak J, 2009, DEV DISABIL RES REV, V15, P328, DOI 10.1002/ddrr.76
VOLKMAR FR, 1993, J AUTISM DEV DISORD, V23, P579, DOI 10.1007/BF01046103
Winston JS, 2002, NAT NEUROSCI, V5, P277, DOI 10.1038/nn816
Woodbury-Smith MR, 2005, J AUTISM DEV DISORD, V35, P331, DOI 10.1007/s10803-005-3300-7
NR 55
TC 6
Z9 6
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1749-5016
J9 SOC COGN AFFECT NEUR
JI Soc. Cogn. Affect. Neurosci.
PD AUG
PY 2012
VL 7
IS 6
BP 689
EP 697
DI 10.1093/scan/nsr041
PG 9
WC Neurosciences; Psychology; Psychology, Experimental
SC Neurosciences & Neurology; Psychology
GA 998JH
UT WOS:000308233400008
PM 21737434
ER
PT J
AU Cox, CL
Uddin, LQ
Di Martino, A
Castellanos, FX
Milham, MP
Kelly, C
AF Cox, Christine L.
Uddin, Lucina Q.
Di Martino, Adriana
Castellanos, F. Xavier
Milham, Michael P.
Kelly, Clare
TI The balance between feeling and knowing: affective and cognitive empathy
are reflected in the brain's intrinsic functional dynamics
SO SOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCE
LA English
DT Article
DE affective empathy; cognitive empathy; fMRI; resting-state functional
connectivity; social cognition
ID RESTING-STATE FMRI; PSYCHOPATHIC TENDENCIES; FRONTOTEMPORAL DEMENTIA;
DOUBLE DISSOCIATION; PERSPECTIVE-TAKING; EMOTIONAL EMPATHY; NEURAL
MECHANISMS; ASPERGER-SYNDROME; SOCIAL COGNITION; CONNECTIVITY
AB Affective empathy (AE) is distinguished clinically and neurally from cognitive empathy (CE). While AE is selectively disrupted in psychopathy, autism is associated with deficits in CE. Despite such dissociations, AE and CE together contribute to normal human empathic experience. A dimensional measure of individual differences in AE 'relative to' CE captures this interaction and may reveal brain-behavior relationships beyond those detectable with AE and CE separately. Using resting-state fMRI and measures of empathy in healthy adults, we show that relative empathic ability (REA) is reflected in the brain's intrinsic functional dynamics. Dominance of AE was associated with stronger functional connectivity among social-emotional regions (ventral anterior insula, orbitofrontal cortex, amygdala, perigenual anterior cingulate). Dominance of CE was related to stronger connectivity among areas implicated in interoception, autonomic monitoring and social-cognitive processing (brainstem, superior temporal sulcus, ventral anterior insula). These patterns were distinct from those observed with AE and CE separately. Finally, REA and the strength of several functional connections were associated with symptoms of psychopathology. These findings suggest that REA provides a dimensional index of empathic function and pathological tendencies in healthy adults, which are reflected in the intrinsic functional dynamics of neural systems associated with social and emotional cognition.
C1 [Cox, Christine L.; Di Martino, Adriana; Castellanos, F. Xavier; Milham, Michael P.; Kelly, Clare] NYU, Ctr Child Study, Phyllis Green & Randolph Cowen Inst Pediat Neuros, Langone Med Ctr, New York, NY 10016 USA.
[Uddin, Lucina Q.] Stanford Univ, Sch Med, Dept Psychiat & Behav Sci, Stanford, CA 94305 USA.
[Castellanos, F. Xavier; Milham, Michael P.] Nathan S Kline Inst Psychiat Res, Orangeburg, NY 10962 USA.
RP Kelly, C (reprint author), NYU, Ctr Child Study, Phyllis Green & Randolph Cowen Inst Pediat Neuros, Langone Med Ctr, 215 Lexington Ave,14th Floor, New York, NY 10016 USA.
EM Clare.Kelly@nyumc.org
RI Milham, Michael/K-9501-2014; Di Martino, Adriana/L-2497-2014
FU National Institute on Drug Abuse [2T32DA007254-16A2, R03DA024775,
R01DA016979]; National Institute of Mental Health [K01MH092288,
K23MH087770, R01MH083246, R01MH081218]; Leon Levy Foundation; Stavros
Niarchos Foundation
FX The authors thank Dr Xi-Nian Zuo for assistance with fALFF analyses, and
all participants for their time and cooperation. This work was supported
by the National Institute on Drug Abuse (2T32DA007254-16A2 for C.L.C.,
R03DA024775 to C.K., and R01DA016979 to F.X.C.); the National Institute
of Mental Health (K01MH092288 to L.Q.U., K23MH087770 to A.D.M., and
R01MH083246 and R01MH081218 to F.X.C. and M.P.M.); the Leon Levy
Foundation (A.D.M. and M.P.M.); the Stavros Niarchos Foundation; and an
endowment from Phyllis Green and Randolph Cowen.
CR Andersson J, 2007, FMRIB ANAL GROUP TEC
Andrews-Hanna JR, 2007, NEURON, V56, P924, DOI 10.1016/j.neuron.2007.10.038
ARNDT S, 1991, PSYCHIAT RES-NEUROIM, V40, P79
Bailey PE, 2008, AGING MENT HEALTH, V12, P499, DOI 10.1080/13607860802224243
Baron-Cohen S, 2004, J AUTISM DEV DISORD, V34, P163, DOI 10.1023/B:JADD.0000022607.19833.00
BISWAL B, 1995, MAGNET RESON MED, V34, P537, DOI 10.1002/mrm.1910340409
Biswal BB, 2010, P NATL ACAD SCI USA, V107, P4734, DOI 10.1073/pnas.0911855107
Blair RJR, 2005, CONSCIOUS COGN, V14, P698, DOI 10.1016/j.concog.2005.06.004
Blair RJR, 2006, J CHILD PSYCHOL PSYC, V47, P262, DOI 10.1111/j.1469-7610.2006.01596.x
BUSS AH, 1992, J PERS SOC PSYCHOL, V63, P452, DOI 10.1037//0022-3514.63.3.452
Carr L, 2003, P NATL ACAD SCI USA, V100, P5497, DOI 10.1073/pnas.0935845100
Carrington SJ, 2009, HUM BRAIN MAPP, V30, P2313, DOI 10.1002/hbm.20671
Cole David M, 2010, Front Syst Neurosci, V4, P8, DOI 10.3389/fnsys.2010.00008
Constantino JN, 2002, SOCIAL RESPONSIVENES
Cox CL, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0012296
Craig AD, 2002, NAT REV NEUROSCI, V3, P655, DOI 10.1038/nrn894
Critchley HD, 2005, J COMP NEUROL, V493, P154, DOI 10.1002/cne.20749
Davis M. H., 1980, JSAS CATALOG SELECTE, V10, P85
DAVIS MH, 1994, J PERS, V62, P369, DOI 10.1111/j.1467-6494.1994.tb00302.x
DAVIS MH, 1983, J PERS SOC PSYCHOL, V44, P113, DOI 10.1037//0022-3514.44.1.113
Decety J, 2010, DEV NEUROSCI-BASEL, V32, P257, DOI 10.1159/000317771
De Corte K, 2007, PSYCHOL BELG, V47, P235
Derogatis L. R., 1994, SYMPTOM CHECKLIST 90
DEUTSCH F, 1975, HUM DEV, V18, P267
Di Martino A, 2009, AM J PSYCHIAT, V166, P891, DOI 10.1176/appi.ajp.2009.08121894
Dziobek I, 2008, J AUTISM DEV DISORD, V38, P464, DOI 10.1007/s10803-007-0486-x
Ebisch SJH, 2011, HUM BRAIN MAPP, V32, P1013, DOI 10.1002/hbm.21085
Fan Y, 2011, NEUROSCI BIOBEHAV R, V35, P903, DOI 10.1016/j.neubiorev.2010.10.009
Fox MD, 2007, NAT REV NEUROSCI, V8, P700, DOI 10.1038/nrn2201
Garrett DD, 2010, J NEUROSCI, V30, P4914, DOI 10.1523/JNEUROSCI.5166-09.2010
Gerschcovich E.R., 2010, NEUROCASE, V17, P270
Greicius MD, 2003, P NATL ACAD SCI USA, V100, P253, DOI 10.1073/pnas.0135058100
Han Y, 2011, NEUROIMAGE, V55, P287, DOI 10.1016/j.neuroimage.2010.11.059
Harari H, 2010, PSYCHIAT RES, V175, P277, DOI 10.1016/j.psychres.2009.03.002
Hooker CI, 2010, BRAIN RES, V1308, P100, DOI 10.1016/j.brainres.2009.10.006
Hoptman MJ, 2010, SCHIZOPHR RES, V117, P13, DOI 10.1016/j.schres.2009.09.030
Hoptman MJ, 2010, SCHIZOPHRENIA BULL, V36, P1020, DOI 10.1093/schbul/sbp012
Hurlemann R, 2010, J NEUROSCI, V30, P4999, DOI 10.1523/JNEUROSCI.5538-09.2010
Hynes CA, 2006, NEUROPSYCHOLOGIA, V44, P374, DOI 10.1016/j.neuropsychologia.2005.06.011
Jenkinson M, 2002, NEUROIMAGE, V17, P825, DOI 10.1006/nimg.2002.1132
Jones AP, 2010, J CHILD PSYCHOL PSYC, V51, P1188, DOI 10.1111/j.1469-7610.2010.02280.x
Kannurpatti SS, 2008, NEUROIMAGE, V40, P1567, DOI 10.1016/j.neuroimage.2007.09.040
Kelly C, 2011, BIOL PSYCHIAT, V69, P684, DOI 10.1016/j.biopsych.2010.11.022
Kerem E, 2001, J SOC PERS RELAT, V18, P709, DOI 10.1177/0265407501185008
Keysers C, 2007, TRENDS COGN SCI, V11, P194, DOI 10.1016/j.tics.2007.02.002
Kunisato Y, 2011, NEUROSCI RES, V69, P129, DOI 10.1016/j.neures.2010.11.005
Kunisato Y, 2011, NEUROSCI LETT, V492, P109, DOI 10.1016/j.neulet.2011.01.067
Kurth F, 2010, BRAIN STRUCT FUNCT, V214, P519, DOI 10.1007/s00429-010-0255-z
Lawrence EJ, 2007, SOC NEUROSCI, V2, P292, DOI 10.1080/17470910701391794
Lough S, 2006, NEUROPSYCHOLOGIA, V44, P950, DOI 10.1016/j.neuropsychologia.2005.08.009
Lui S, 2010, ARCH GEN PSYCHIAT, V67, P783, DOI 10.1001/archgenpsychiatry.2010.84
Mennes M, 2011, NEUROIMAGE, V54, P2950, DOI 10.1016/j.neuroimage.2010.10.046
MILLER PA, 1988, PSYCHOL BULL, V103, P324, DOI 10.1037/0033-2909.103.3.324
Moriguchi Y, 2007, CEREB CORTEX, V17, P2223, DOI 10.1093/cercor/bhl130
Nummenmaa L, 2008, NEUROIMAGE, V43, P571, DOI 10.1016/j.neuroimage.2008.08.014
Patton JH, 1995, J CLIN PSYCHOL, V51, P768, DOI 10.1002/1097-4679(199511)51:6<768::AID-JCLP2270510607>3.0.CO;2-1
Rankin KP, 2006, BRAIN, V129, P2945, DOI 10.1093/brain/awl254
Reniers RLEP, 2011, J PERS ASSESS, V93, P84, DOI 10.1080/00223891.2010.528484
Ritter K, 2011, PSYCHIAT RES, V187, P241, DOI 10.1016/j.psychres.2010.09.013
Saxe R, 2006, CURR OPIN NEUROBIOL, V16, P235, DOI 10.1016/j.conb.2006.03.001
Shamay-Tsoory S, 2009, J NEUROPSYCH CLIN N, V21, P59, DOI 10.1176/appi.neuropsych.21.1.59
Shamay-Tsoory SG, 2009, BRAIN, V132, P617, DOI 10.1093/brain/awn279
Shamay-Tsoory Simone G, 2011, Neuroscientist, V17, P18, DOI 10.1177/1073858410379268
Shamay-Tsoory SG, 2007, PSYCHIAT RES, V149, P11, DOI 10.1016/j.psychres.2005.10.018
Shamay-Tsoory SG, 2010, CORTEX, V46, P668, DOI 10.1016/j.cortex.2009.04.008
Shane MS, 2009, SOC COGN AFFECT NEUR, V4, P111, DOI 10.1093/scan/nsn043
Shehzad Z, 2009, CEREB CORTEX, V19, P2209, DOI 10.1093/cercor/bhn256
Shur Syvan, 2008, Cogn Neuropsychiatry, V13, P472, DOI 10.1080/13546800802490034
Singer T, 2004, SCIENCE, V303, P1157, DOI 10.1126/science.1093535
Skuse DH, 2011, PEDIATR RES, V69, p85R, DOI 10.1203/PDR.0b013e318212f562
Smith SM, 2009, P NATL ACAD SCI USA, V106, P13040, DOI 10.1073/pnas.0905267106
Toro R, 2008, CEREB CORTEX, V18, P2553, DOI 10.1093/cercor/bhn014
Zaki J, 2009, P NATL ACAD SCI USA, V106, P11382, DOI 10.1073/pnas.0902666106
Zhang S, 2010, NEUROIMAGE, V49, P1911, DOI 10.1016/j.neuroimage.2009.09.004
Zhou J, 2010, BRAIN, V133, P1352, DOI 10.1093/brain/awq075
Zou QH, 2008, J NEUROSCI METH, V172, P137, DOI 10.1016/j.jneumeth.2008.04.012
Zuo XN, 2010, NEUROIMAGE, V49, P1432, DOI 10.1016/j.neuroimage.2009.09.037
NR 77
TC 29
Z9 31
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1749-5016
J9 SOC COGN AFFECT NEUR
JI Soc. Cogn. Affect. Neurosci.
PD AUG
PY 2012
VL 7
IS 6
BP 727
EP 737
DI 10.1093/scan/nsr051
PG 11
WC Neurosciences; Psychology; Psychology, Experimental
SC Neurosciences & Neurology; Psychology
GA 998JH
UT WOS:000308233400012
PM 21896497
ER
PT J
AU Kadar, M
McDonald, R
Lentin, P
AF Kadar, Masne
McDonald, Rachael
Lentin, Primrose
TI Evidence-based practice in occupational therapy services for children
with autism spectrum disorders in Victoria, Australia
SO AUSTRALIAN OCCUPATIONAL THERAPY JOURNAL
LA English
DT Article
DE interventions; professional development; theory
ID PRESCHOOL-CHILDREN; INTERVENTIONS; FRAMEWORK; EFFICACY; FAMILIES;
BEHAVIOR; CONTEXT
AB Background The current practice of occupational therapy services provided for children with autism spectrum disorders in Victoria, Australia was investigated specifically, practice in terms of the theories, assessments and intervention strategies utilised. Identification of professional development needs was also explored. The purpose was to identify how occupational therapy practice may have changed over the last decade and to explore what additional developments are required in the field. Method A self-administered survey was mailed to 322 registered members of Occupational Therapy Australia Limited, Victoria Branch. Results A valid response rate of 20.5% was obtained. The majority of the participants worked in private practice, and had between one and five years of work experience. Theories, assessments and interventions that are associated with or based on, sensory integration and/or processing approaches are highly utilised by the participants in their service delivery with children with autism spectrum disorders. Participants indicated that they felt they needed training and courses around sensory integration. Conclusions We concluded that there were few changes in occupational therapy practice related to the selection of theoretical models, assessments and interventions by the participants in this study over the last decade. It is essential for occupational therapists not to neglect the goals of providing occupation-based interventions to children with autism spectrum disorders by focusing only on sensory-based approaches. An urgent need for occupation-based approaches to working with children with autism spectrum disorders and their families is required.
C1 [Kadar, Masne; McDonald, Rachael; Lentin, Primrose] Monash Univ, Dept Occupat Therapy, Fac Med, Sch Primary Hlth Care Nursing & Hlth Sci, Frankston, Vic 3199, Australia.
[McDonald, Rachael] Business Ctr Monash, OMNICO, Ctr Dev Disabil Hlth Victoria, Notting Hill, Vic, Australia.
RP Kadar, M (reprint author), Monash Univ, Dept Occupat Therapy, Fac Med, Sch Primary Hlth Care Nursing & Hlth Sci, Bldg G Level 4,Peninsula Campus, Frankston, Vic 3199, Australia.
EM mkad7@student.monash.edu
CR Adamson A, 2006, BRIT J OCCUPATIONAL, V69, P357
Ashburner J., 2010, CURRENT PRACTI UNPUB
Ayres A. J., 1989, SENSORY INTEGRATION
Bailey DB, 2000, J AUTISM DEV DISORD, V30, P49
Baranek GT, 2002, J AUTISM DEV DISORD, V32, P397, DOI 10.1023/A:1020541906063
Baron-Cohen S, 2009, BRIT J PSYCHIAT, V194, P500, DOI 10.1192/bjp.bp.108.059345
Beery K., 1997, BEERY BUKTENICA DEV
Brown G. T., 2001, PAEDIAT OCCUPA UNPUB
Bruininks R. H., 1978, BRUININKS OSERETSKY
Bruininks R. H., 2005, BRUININKS OSERETSKY
Cale SI, 2009, BEHAV MODIF, V33, P707, DOI 10.1177/0145445509340775
Case-Smith J, 2005, OCCUPATIONAL THERAPY
Case-Smith J, 2008, AM J OCCUP THER, V62, P416
Coster W., 1998, SCH FUNCTION ASSESSM
Dawson G, 2000, J AUTISM DEV DISORD, V30, P415, DOI 10.1023/A:1005547422749
DUNN W, 1994, AM J OCCUP THER, V48, P595
Dunn W., 2006, SENSORY PROFILE SCH
Dunn W., 1999, SENSORY PROFILE
Fisher A., 2003, ASSESSMENT MOTOR PRO
Fisher A. G., 2005, SCH AMPS SCH VERSION
Folio M. R., 1983, PEABODY DEV MOTOR SC
Folio R., 2000, PEABODY DEV MOTOR SC
Gray DE, 2002, J INTELLECT DEV DIS, V27, P215, DOI 10.1080/1366825021000008639
Greenspan S. L., 1992, INFANCY ANS EARLY CH
Haley SM, 1992, PEDIAT EVALUATION DI
Harrison P., 2003, ADAPTIVE BEHAV ASSES, V2nd
Heflin L.J., 1998, FOCUS AUTISM OTHER D, V13, P194, DOI DOI 10.1177/108835769801300401
Henry D. A., 2007, SENSORY PROCESSING M
Huebner RA, 2001, AUTISM SENSORIMOTOR, P61
Hyatt K. J., 2009, ED TREATEMENT CHILDR, V32, P313, DOI DOI 10.1353/ETC.0.0054
Jasmin E, 2009, J AUTISM DEV DISORD, V39, P231, DOI 10.1007/s10803-008-0617-z
Johnston E. B., 1991, SOURCEBOOK PRAGMATIC
Kielhofner G., 2008, MODEL HUMAN OCCUPATI
KIELHOFNER G, 1980, AM J OCCUP THER, V34, P572
Kimball J., 1999, FRAMES REFERENCE PED, P169
Kramer P, 2010, FRAMES REFERENCE PED
Law M., 1994, CANADIAN OCCUPATIONA
Law M., 1996, CANADIAN J OCCUPATIO, V63, P9, DOI 10.1177/000841749906600304
Liamputtong P., 2009, QUALITATIVE RES METH, V3rd
McLennan JD, 2008, J AUTISM DEV DISORD, V38, P1192, DOI 10.1007/s10803-007-0535-5
Mesibov G., 2004, TEACCH APPROACH AUTI
Miller LJ, 2006, MILLER FUNCTION PART
Miller-Kuhaneck H, 2004, AUTISM COMPREHENSIVE
Mulligan S, 2003, OCCUPATIONAL THERAPY
Olson L, 1999, FRAMES REFERENCE PED, P323
Polatajko H., 2004, ENABLING OCCUPATION
Primeau L. A., 1999, FRAMES REFERENCE PED, P469
Prizant BM, 2006, SCERTS MODEL COMPREH
Rodger S., 2005, AUSTR OCCUPATIONAL T, V52, P311, DOI DOI 10.1111/J.1440-1630.2005.00487.X
Rodger S, 2010, AUST OCCUP THER J, V57, P276, DOI 10.1111/j.1440-1630.2010.00877.x
Royeen C. B., 1999, FRAMES REFERENCE PED, P377
Salant P., 1994, CONDUCT YOUR OWN SUR
Schopler E., 2005, PSYCHOEDUCATIONAL PR
Schopler E., 1988, CHILDHOOD AUTISM RAT
Spreckley M, 2009, J PEDIATR-US, V154, P338, DOI 10.1016/j.jpeds.2008.09.012
Stagnitti K, 2007, CHILD INITIATED PRET
Townsend EA, 2007, ENABLING OCCUPATION
Vismara LA, 2009, J AUTISM DEV DISORD, V39, P1636, DOI 10.1007/s10803-009-0796-2
Vort Corporation, 2004, HAW EARL LEARN PROF
Watling R, 1999, CURRENT PRACTICE OCC
Watling R, 1999, AM J OCCUP THER, V53, P498
Weisberg Herbert F., 1996, INTRO SURVEY RES POL
Williamson G., 1999, FRAMES REFERENCE PED, P431
WOLF LC, 1989, J AUTISM DEV DISORD, V19, P157, DOI 10.1007/BF02212727
NR 64
TC 4
Z9 4
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0045-0766
J9 AUST OCCUP THER J
JI Aust. Occup. Ther. J.
PD AUG
PY 2012
VL 59
IS 4
BP 284
EP 293
DI 10.1111/j.1440-1630.2012.01015.x
PG 10
WC Rehabilitation
SC Rehabilitation
GA 997ZA
UT WOS:000308205800005
PM 22934901
ER
PT J
AU Stagnitti, K
O'Connor, C
Sheppard, L
AF Stagnitti, Karen
O'Connor, Chloe
Sheppard, Loretta
TI Impact of the Learn to Play program on play, social competence and
language for children aged 5-8 years who attend a specialist school
SO AUSTRALIAN OCCUPATIONAL THERAPY JOURNAL
LA English
DT Article
DE autism; developmental disability; intervention; pretend play
ID YOUNG-CHILDREN; SYMBOLIC PLAY; PEER PLAY; AUTISM; SCALE; MODEL
AB Introduction The aim of this study was to investigate the change in the relationship between play, language and social skills of children aged 58 years pre and post participation in the Learn to Play program. The Learn to Play program is a child led play based intervention aimed at developing self-initiated pretend play skills in children. Methods All 19 participants attended a specialist school, with 10 of the 19 children having a diagnosis of autism. The play, language and social skills of the children were assessed at baseline and at follow up. Children were assessed using the Child-Initiated Pretend Play Assessment, the Preschool Language Scale and the Penn Interactive Peer Play Scale. Follow up data collection occurred after the children had been participating in the Learn to Play program for 1 hour twice a week for 6 months. Results After 6 months in the program, typical indicators of play accounted for an increase of 47.3% in shared variance with social interaction and an increase of 36% in shared variance for social connection. For language, object substitution ability accounted for 50% of the shared variance, which was an increase of 27% from baseline. Conclusion The Learn to Play program was associated with increases in children's language and social skills over a 6-month period within a special school setting, indicating the Learn to Play program is an effective intervention for children with developmental disabilities. This paper presents an example of how the Learn to Play program can be adapted into a classroom setting.
C1 [Stagnitti, Karen; O'Connor, Chloe] Deakin Univ, Sch Hlth & Social Dev, Deakin, Vic, Australia.
[Sheppard, Loretta] Australian Catholic Univ, Melbourne, Vic, Australia.
RP Stagnitti, K (reprint author), Deakin Univ, Sch Hlth & Social Dev, Waterfront Campus,Gheringhap St, Geelong, Vic 3217, Australia.
EM karen.Stagnitti@deakin.edu.au
CR Bergen D., 2001, 458045 ERIC CLEAR EL
Cunillera T, 2010, Q J EXP PSYCHOL, V63, P260, DOI 10.1080/17470210902888809
Doidge Norman, 2010, BRAIN CHANGES ITSELF
FANTUZZO J, 1995, EARLY CHILD RES Q, V10, P105, DOI 10.1016/0885-2006(95)90028-4
Guralnick MJ, 2006, AM J MENT RETARD, V111, P336, DOI 10.1352/0895-8017(2006)111[336:PTPSDO]2.0.CO;2
Hampton V., 1999, NHSA DIALOG, V3, P70, DOI 10.1207/s19309325nhsa0301_8
HOWES C, 1992, DEV PSYCHOL, V28, P961, DOI 10.1037//0012-1649.28.5.961
Lantz J. F., 2004, TEACHING EXCEPTIONAL, V37, P8
Lewis V, 2000, INT J LANG COMM DIS, V35, P117
LEWIS V, 1992, EUR J DISORDER COMM, V27, P231
Mandich A, 2006, OCCUPATIONAL THERAPY, P115
McAloney K., 2009, INT J PLAY THERAPY, V18, P99
MCCUNE L, 1995, DEV PSYCHOL, V31, P198, DOI 10.1037//0012-1649.31.2.198
O'Connor C, 2011, RES DEV DISABIL, V32, P1205, DOI 10.1016/j.ridd.2010.12.037
Peter M., 2003, BRIT J SPECIAL ED, V30, P21, DOI 10.1111/1467-8527.00277
Portney LG., 2000, FDN CLIN RES APPL PR
Rodger S., 2006, OCCUPATIONAL THERAPY, P177
Russ SW, 1998, J CLIN CHILD PSYCHOL, V27, P469, DOI 10.1207/s15374424jccp2704_11
Seja AL, 1999, J CLIN CHILD PSYCHOL, V28, P269, DOI 10.1207/s15374424jccp2802_13
Sigafoos J, 1999, RES DEV DISABIL, V20, P147, DOI 10.1016/S0891-4222(98)00038-9
Stagnitti K., 2010, OCCUPATIONAL THERAPY, P371
Stagnitti K, 2007, CHILD INITIATED PRET
Stagnitti K., 2009, PLAY THERAPY ASSESSM, P176
Stagnitti K, 1998, LEARN PLAY PRACTICAL
Stagnitti K., 2011, AUTISMO OGGI, V20, P8
Stagnitti K., 2004, OCCUPATION OCCUPATIO, P103
Whitington V., 2009, EARLY CHILD DEV CARE, V179, P143, DOI [10.1080/03004430802667054, DOI 10.1080/03004430802667054]
WOLFBERG PJ, 1993, J AUTISM DEV DISORD, V23, P467, DOI 10.1007/BF01046051
Yang TR, 2003, AUTISM, V7, P437, DOI 10.1177/1362361303007004009
Zimmerman I., 2002, PRESCHOOL LANGUAGE S, V4th
Zimmerman IL, 2005, MENT RETARD DEV D R, V11, P238, DOI 10.1002/mrdd.20078
NR 31
TC 2
Z9 2
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0045-0766
J9 AUST OCCUP THER J
JI Aust. Occup. Ther. J.
PD AUG
PY 2012
VL 59
IS 4
BP 302
EP 311
DI 10.1111/j.1440-1630.2012.01018.x
PG 10
WC Rehabilitation
SC Rehabilitation
GA 997ZA
UT WOS:000308205800007
PM 22934903
ER
PT J
AU Rovelet-Lecrux, A
Campion, D
AF Rovelet-Lecrux, Anne
Campion, Dominique
TI Copy number variations involving the microtubule-associated protein tau
in human diseases
SO BIOCHEMICAL SOCIETY TRANSACTIONS
LA English
DT Article
DE copy number variation; microtubule; neurodegenerative disorder;
schizophrenia; tau
ID HUMAN GENOME; 17Q21.31 MICRODUPLICATION; DEVELOPMENTAL DELAY; COMMON
INVERSION; MAPT GENE; MICE; MICRODELETION; SAITOHIN; PHOSPHORYLATION;
REARRANGEMENTS
AB Mutations of the MAPT (microtubule-associated protein tau) gene are associated with FTLD (frontotemporal lobar degeneration) with tau pathology. These mutations result in a decreased ability of tau to bind MTs (microtubules), an increased production of tau with four MT-binding repeats or enhanced tau aggregation. In two FTLD patients, we recently described CNVs (copy number variations) affecting the MAPT gene, consisting of a partial deletion and a complete duplication of the gene. The partial deletion resulted in a truncated protein lacking the first MT-binding domain, which had a dramatic decrease in the binding to MTs but acquired the ability to bind MAP (microtubule-associated protein) 1-B. In this case, tauopathy probably resulted from both a loss of normal function and a gain of function by which truncated tau would sequester another MAP. In the other FTLD patient, the complete duplication might result in the overexpression of tau, which in the mouse model induces axonopathy and tau aggregates reminiscent of FTLD-tau pathology. Interestingly, the same rearrangement was also described in several children with mental retardation, autism spectrum disorders and dysmorphic features, as well as in a schizophrenic patient. Finally, complete deletions of the MAPT gene have been associated with mental retardation, hypotonia and facial dysmorphism.
C1 [Rovelet-Lecrux, Anne; Campion, Dominique] INSERM, U1079, Rouen, France.
[Rovelet-Lecrux, Anne; Campion, Dominique] Univ Rouen, Inst Res & Innovat Biomed, Rouen, France.
RP Rovelet-Lecrux, A (reprint author), INSERM, U1079, Rouen, France.
EM anne.roveletlecrux@univ-rouen.fr
FU Inserm grants; G4 grants [2004/147/HP-UF R 809]
FX Studies in our laboratory were supported by Inserm grants and by G4
grants [contract grant number 2004/147/HP-UF R 809].
CR Alonso AD, 1997, P NATL ACAD SCI USA, V94, P298, DOI 10.1073/pnas.94.1.298
Bosia M, 2012, NEUROL SCI, V33, P1051, DOI 10.1007/s10072-011-0893-9
Conrad C, 2002, P NATL ACAD SCI USA, V99, P7751, DOI 10.1073/pnas.112194599
Cruts M, 2005, HUM MOL GENET, V14, P1753, DOI 10.1093/hmg/ddi182
Dawson HN, 2001, J CELL SCI, V114, P1179
Dubourg C, 2011, EUR J MED GENET, V54, P144, DOI 10.1016/j.ejmg.2010.11.003
El Chehadeh-Djebbar S, 2011, EUR J MED GENET, V54, P369, DOI 10.1016/j.ejmg.2011.03.001
Feuk L, 2006, NAT REV GENET, V7, P85, DOI 10.1038/nrg1767
Frank S, 2008, ACTA NEUROPATHOL, V115, P39, DOI 10.1007/s00401-007-0291-9
Gao L, 2005, J BIOL CHEM, V280, P39268, DOI 10.1074/jbc.M506116200
Goode BL, 2000, J BIOL CHEM, V275, P38182, DOI 10.1074/jbc.M007489200
Grisart B, 2009, J MED GENET, V46, P524, DOI 10.1136/jmg.2008.065367
Guilmatre A, 2009, ARCH GEN PSYCHIAT, V66, P947, DOI 10.1001/archgenpsychiatry.2009.80
HARADA A, 1994, NATURE, V369, P488, DOI 10.1038/369488a0
Iafrate AJ, 2004, NAT GENET, V36, P949, DOI 10.1038/ng1416
Jakel S, 2002, EMBO J, V21, P377, DOI 10.1093/emboj/21.3.377
Kirchhoff M, 2007, EUR J MED GENET, V50, P256, DOI 10.1016/j.ejmg.2007.05.001
Kitsiou-Tzeli S., 2011, GENE, V492, P319
Koolen DA, 2006, NAT GENET, V38, P999, DOI 10.1038/ng1853
Lee JA, 2006, NEURON, V52, P103, DOI 10.1016/j.neuron.2006.09.027
Levecque C, 2004, J NEUROL NEUROSUR PS, V75, P478, DOI 10.1136/jnnp.2003.015750
Li BJ, 2000, NAT GENET, V24, P304, DOI 10.1038/73542
LUPSKI JR, 1993, JAMA-J AM MED ASSOC, V270, P2326, DOI 10.1001/jama.270.19.2326
Papaleo F, 2007, NEURON, V53, P577, DOI 10.1016/j.neuron.2007.01.022
Perry GH, 2008, GENOME RES, V18, P1698, DOI 10.1101/gr.082016.108
Redon R, 2006, NATURE, V444, P444, DOI 10.1038/nature05329
Rovelet-Lecrux A, 2009, HUM MUTAT, V30, pE591, DOI 10.1002/humu.20979
Rovelet-Lecrux A, 2010, J ALZHEIMERS DIS, V21, P897, DOI 10.3233/JAD-2010-100441
Sapir T, 2012, HUM MOL GENET, V21, P1681, DOI 10.1093/hmg/ddr603
Sebat J, 2004, SCIENCE, V305, P525, DOI 10.1126/science.1098918
Shaw-Smith C, 2006, NAT GENET, V38, P1032, DOI 10.1038/ng1864
Shchelochkov OA, 2010, AM J MED GENET A, V152A, P1101, DOI 10.1002/ajmg.a.33248
Smith GW, 1998, NEURON, V20, P1093, DOI 10.1016/S0896-6273(00)80491-2
Stefansson H, 2005, NAT GENET, V37, P129, DOI 10.1038/ng1508
Wang Y, 2011, J CELL BIOCHEM, V112, P3482, DOI 10.1002/jcb.23279
NR 35
TC 5
Z9 7
PU PORTLAND PRESS LTD
PI LONDON
PA THIRD FLOOR, EAGLE HOUSE, 16 PROCTER STREET, LONDON WC1V 6 NX, ENGLAND
SN 0300-5127
J9 BIOCHEM SOC T
JI Biochem. Soc. Trans.
PD AUG
PY 2012
VL 40
BP 672
EP 676
DI 10.1042/BST20120045
PN 4
PG 5
WC Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA 987QH
UT WOS:000307431700014
PM 22817714
ER
PT J
AU Mizejewski, GJ
AF Mizejewski, Gerald J.
TI Biomarker testing for suspected autism spectrum disorder in early
childhood: is such testing now feasible?
SO BIOMARKERS IN MEDICINE
LA English
DT Editorial Material
DE autism; biomarkers; brain disorders; mental retardation; neonate
testing; neuropeptide; social deficit; speech impairment
ID NEONATAL BLOOD; DOWN-SYNDROME; CHILDREN; NEUROTROPHINS; NEUROPEPTIDES;
MULTIPLEX
C1 New York State Dept Hlth, Wadsworth Ctr, Div Translat Med, Albany, NY 12201 USA.
RP Mizejewski, GJ (reprint author), New York State Dept Hlth, Wadsworth Ctr, Div Translat Med, Empire State Plaza, Albany, NY 12201 USA.
EM mizejew@wadsworth.org
CR Amaral DG, 2008, TRENDS NEUROSCI, V31, P137, DOI 10.1016/j.tins.2007.12.005
Bohlander AJ, 2012, PEDIATR CLIN N AM, V59, P165, DOI 10.1016/j.pcl.2011.10.001
Bolte S, 2011, AUTISM, V15, P497, DOI 10.1177/1362361310391116
Bolton PF, 1997, J AM ACAD CHILD PSY, V36, P272, DOI 10.1097/00004583-199702000-00018
Cheung C, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0020246
Correia CT, 2010, GENES BRAIN BEHAV, V9, P841, DOI 10.1111/j.1601-183X.2010.00627.x
de Cock M, 2012, ACTA PAEDIATR, V101, P811, DOI 10.1111/j.1651-2227.2012.02693.x
Downey R, 2012, PEDIATR PHYS THER, V24, P2, DOI 10.1097/PEP.0b013e31823db95f
Fisch GS, 2012, AM J MED GENET A, V158A, P969, DOI 10.1002/ajmg.a.35269
Fombonne E, 2005, J CLIN PSYCHIAT, V66, P3
Fountain C, 2011, J EPIDEMIOL COMMUN H, V65, P503, DOI 10.1136/jech.2009.104588
Ganz ML, 2007, ARCH PEDIAT ADOL MED, V161, P343, DOI 10.1001/archpedi.161.4.343
Joosten AV, 2012, J APPL RES INTELLECT, V25, P262, DOI 10.1111/j.1468-3148.2011.00663.x
Kent L, 1999, DEV MED CHILD NEUROL, V41, P153, DOI 10.1017/S001216229900033X
Lainhart JE, 2011, JAMA-J AM MED ASSOC, V306, P2031, DOI 10.1001/jama.2011.1633
LeBlanc LA, 2012, PEDIATR CLIN N AM, V59, P147, DOI 10.1016/j.pcl.2011.10.006
Lindau-Shepard BA, 2010, CLIN CHEM, V56, P445, DOI 10.1373/clinchem.2009.132480
McPartland JC, 2012, J AM ACAD CHILD PSY, V51, P368, DOI 10.1016/j.jaac.2012.01.007
Mines MA, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009706
Nelson KB, 2001, ANN NEUROL, V49, P597, DOI 10.1002/ana.1024
Nelson PG, 2006, INT J DEV NEUROSCI, V24, P73, DOI 10.1016/j.ijdevneu.2005.10.003
Rajapakse T, 2010, SEMIN PEDIATR NEUROL, V17, P254, DOI 10.1016/j.spen.2010.10.008
Angelidou A, 2010, J NEUROINFLAMM, V7, DOI 10.1186/1742-2094-7-48
Virkud YV, 2009, AM J MED GENET B, V150B, P328, DOI 10.1002/ajmg.b.30810
Woolfenden S, 2012, DEV MED CHILD NEUROL, V54, P306
Yazbak FE, 2004, BRIT MED J, V328, P226, DOI 10.1136/bmj.328.7433.226-c
Zaroff CM, 2012, SOC PSYCH PSYCH EPID, V47, P395, DOI 10.1007/s00127-011-0350-3
NR 27
TC 3
Z9 3
PU FUTURE MEDICINE LTD
PI LONDON
PA UNITEC HOUSE, 3RD FLOOR, 2 ALBERT PLACE, FINCHLEY CENTRAL, LONDON, N3
1QB, ENGLAND
SN 1752-0363
J9 BIOMARK MED
JI Biomark. Med.
PD AUG
PY 2012
VL 6
IS 4
BP 503
EP 506
DI 10.2217/BMM.12.34
PG 4
WC Medicine, Research & Experimental
SC Research & Experimental Medicine
GA 986ES
UT WOS:000307324600015
PM 22917150
ER
PT J
AU Lawton, K
Kasari, C
AF Lawton, Kathy
Kasari, Connie
TI Teacher-Implemented Joint Attention Intervention: Pilot Randomized
Controlled Study for Preschoolers With Autism
SO JOURNAL OF CONSULTING AND CLINICAL PSYCHOLOGY
LA English
DT Article
DE autism; teacher; intervention; preschool; joint attention
ID YOUNG-CHILDREN; LANGUAGE; PLAY
AB Objective: The vast majority of children with an autism spectrum disorder (ASD) attend public preschools at some point in their childhood. Community preschool practices often are not evidence based, and almost none target the prelinguistic core deficits of ASD. This study investigated the effectiveness of public preschool teachers implementing a validated intervention (the Joint Attention and Symbolic Play/Engagement and Regulation intervention; JASP/ER) on a core deficit of autism, initiating joint attention. Method: Sixteen dyads (preschoolers with ASD and the public school teachers who worked in the child's classroom) were randomly assigned to the 6-week JASP/ER intervention or a control group. Results: At the end of the intervention, JASP/ER teachers used more JASP/ER strategies than the control teachers, and JASP/ER preschoolers used more joint attention in their classroom than control children. Additionally, JASP/ER children spent more time in supported engagement and less time in object engagement than control preschoolers on a taped play interaction. Conclusions: Findings suggest that teachers were able to improve a core deficit of children with ASD in a public preschool context.
C1 [Lawton, Kathy] Ohio State Univ, Nisonger Ctr, Columbus, OH 43210 USA.
[Kasari, Connie] Univ Calif Los Angeles, Ctr Autism Res & Treatment, Los Angeles, CA 90024 USA.
RP Lawton, K (reprint author), Ohio State Univ, Nisonger Ctr, 371 McCampbell Hall,1851 Dodd Dr, Columbus, OH 43210 USA.
EM Kathy.lawton@osumc.edu
CR Adamson LB, 2004, CHILD DEV, V75, P1171, DOI 10.1111/j.1467-8624.2004.00732.x
TOMASELLO M, 1986, CHILD DEV, V57, P1454, DOI 10.1111/j.1467-8624.1986.tb00470.x
Han SS, 2005, J ABNORM CHILD PSYCH, V33, P665, DOI 10.1007/s10802-005-7646-2
Harms T., 1980, EARLY CHILDHOOD ENV
Hess KL, 2008, J AUTISM DEV DISORD, V38, P961, DOI 10.1007/s10803-007-0470-5
JACOBSON NS, 1991, J CONSULT CLIN PSYCH, V59, P12, DOI 10.1037//0022-006X.59.1.12
Kasari C, 2006, J CHILD PSYCHOL PSYC, V47, P611, DOI 10.1111/j.1469-7610.2005.01567.x
Kasari C, 2008, J CONSULT CLIN PSYCH, V76, P125, DOI 10.1037/0022-006X.76.1.125
Kasari C, 2010, J AUTISM DEV DISORD, V40, P1045, DOI 10.1007/s10803-010-0955-5
Keen D, 2005, J DEV PHYS DISABIL, V17, P19, DOI 10.1007/s10882-005-2198-5
Lawton K., 2010, YOUNG EXCEPTIONAL CH, V12, P66
Lord C., 2002, AUTISM DIAGNOSTIC OB
Mullen E, 1995, MULLEN SCALES EARLY
Mundy P., 2003, MANUAL ABRIDGE UNPUB
MUNDY P, 1986, J CHILD PSYCHOL PSYC, V27, P657, DOI 10.1111/j.1469-7610.1986.tb00190.x
MUNDY P, 1990, J AUTISM DEV DISORD, V20, P115, DOI 10.1007/BF02206861
Stahmer AC, 2007, ADM POLICY MENT HLTH, V34, P29, DOI 10.1007/s10488-006-0060-4
NR 17
TC 13
Z9 13
PU AMER PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA
SN 0022-006X
J9 J CONSULT CLIN PSYCH
JI J. Consult. Clin. Psychol.
PD AUG
PY 2012
VL 80
IS 4
BP 687
EP 693
DI 10.1037/a0028506
PG 7
WC Psychology, Clinical
SC Psychology
GA 979YW
UT WOS:000306861800015
PM 22582764
ER
PT J
AU Kloiber, S
Czamara, D
Karbalai, N
Muller-Myhsok, B
Hennings, J
Holsboer, F
Lucae, S
AF Kloiber, Stefan
Czamara, Darina
Karbalai, Nazanin
Mueller-Myhsok, Bertram
Hennings, Johannes
Holsboer, Florian
Lucae, Susanne
TI ANK3 and CACNA1C-Missing genetic link for bipolar disorder and major
depressive disorder in two German case-control samples
SO JOURNAL OF PSYCHIATRIC RESEARCH
LA English
DT Article
DE Depression; Genetics; Bipolar disorder; CACNA1C; ANK3
ID GENOME-WIDE ASSOCIATION; UNIPOLAR DEPRESSION; SCHIZOPHRENIA; SPECTRUM;
CHANNEL; FAMILY; AUTISM; RISK; LOCI
AB Recent genome-wide association studies (GWAS) and metaanalyses revealed genetic associations for ANK3 (ankyrin 3) and CACNA1C (alpha 1C subunit of the L-type voltage gated calcium channel) with bipolar disorder (BPD). Several findings from clinical, epidemiological, and genetic studies point towards a common biological background of BPD and major depressive disorder (MDD). We were interested whether this also applies for ANK3 and CACNA1C and tested associations of single nucleotide polymorphisms (SNPs) in these genes with MOD in two Caucasian case-control samples. Sample 1 (Munich Antidepressant Response Signature Project/MARS - MOD) consisted of 720 depressed inpatients and 542 psychiatric healthy controls. Sample 2 (unipolar recurrent depression (URD)) consisted of 827 patients with URD and 860 psychiatric healthy controls. After stringent quality control we analyzed 262 SNPs (sample 1) and 504 SNPs (sample 2) and imputed further 5771 SNPs (sample 1) and 5534 SNPs (sample 2) from Hapmap Phase 2 data in the ANK3 and CACNA1C gene regions. Additionally, a meta-analysis of both samples was performed. Several SNPs in both genes were nominally associated with MDD with the highest association in the 3'-region of ANK3 (rs10994143, nominal p = 3.3*10(-4)) in the metaanalysis of both samples. None of these results remained significant after correction for multiple testing. No association of MDD with SNPs previously reported in BPD studies could be detected. By analyzing the LD-structure, our highest associated SNPs could not be linked to the SNPs previously reported in BPD. Regarding ANK3 and CACNA1C, our findings do not support a strong genetic link between BPD and MOD for these two genes. (C) 2012 Elsevier Ltd. All rights reserved.
C1 [Kloiber, Stefan; Czamara, Darina; Karbalai, Nazanin; Mueller-Myhsok, Bertram; Hennings, Johannes; Holsboer, Florian; Lucae, Susanne] Max Planck Inst Psychiat, Munich, Germany.
RP Kloiber, S (reprint author), Max Planck Inst Psychiat, Kraepelinstr 2-10, Munich, Germany.
EM stkloiber@mpipsykl.mpg.de
RI Muller-Myhsok, Bertram/A-3289-2013
FU Max Planck Society; German Federal Ministry for Education and Research
(BMBF) [FKZ 01GS0481]; BMBF [01ES0811]; Max Planck Excellence Foundation
FX This work was funded by the Max Planck Society and in part by a research
grant from the German Federal Ministry for Education and Research (BMBF)
in the framework of the National Genome Research Network (NGFN2 and
NGFN-Plus, FKZ 01GS0481) and by the BMBF Program "Molecular Diagnostics:
Validation of Biomarkers for Diagnosis and Outcome in Major Depression"
(01ES0811). The authors' research on personalized medicine is supported
by the Max Planck Excellence Foundation.
CR AKISKAL HS, 1995, ARCH GEN PSYCHIAT, V52, P114
American Psychiatric Association (APA), 1994, DIAGN STAT MAN MENT, V4th
ANDREASEN NC, 1987, ARCH GEN PSYCHIAT, V44, P461
Angst J, 2005, J AFFECT DISORDERS, V84, P149, DOI 10.1016/S0165-0327(03)00195-2
Athanasiu L, 2010, J PSYCHIATR RES, V44, P748, DOI 10.1016/j.jpsychires.2010.02.002
Barden N, 2006, AM J MED GENET B, V141B, P374, DOI 10.1002/ajmg.b.30303
Breen G, 2010, NAT GENET, V43, P3
Cassano GB, 2004, AM J PSYCHIAT, V161, P1264, DOI 10.1176/appi.ajp.161.7.1264
Cichon S, 2007, HUM MOL GENET
Ferreira MAR, 2008, NAT GENET, V40, P1056, DOI 10.1038/ng.209
GERSHON ES, 1982, ARCH GEN PSYCHIAT, V39, P1157
Green EK, 2009, MOL PSYCHIAT
Hennings JM, 2008, J PSYCHIATR RES, V43, P215, DOI 10.1016/j.jpsychires.2008.05.002
HILL W G, 1968, Theoretical and Applied Genetics, V38, P226, DOI 10.1007/BF01245622
Huang ZJ, 2006, NAT NEUROSCI, V9, P163, DOI 10.1038/nn1638
Ising M, 2009, ARCH GEN PSYCHIAT, V66, P966, DOI 10.1001/archgenpsychiatry.2009.95
Jiang X, 2011, MOL PSYCHIAT
Kohli MA, 2011, NEURON, V70, P252, DOI 10.1016/j.neuron.2011.04.005
Lee MTM, 2011, MOL PSYCHIATR, V16, P548, DOI 10.1038/mp.2010.43
Linke J, 2012, NEUROIMAGE, V59, P3288, DOI 10.1016/j.neuroimage.2011.10.083
Liu Y, 2011, MOL PSYCHIATR, V16, P2, DOI 10.1038/mp.2009.107
Lucae S, 2006, HUM MOL GENET, V15, P2438, DOI 10.1093/hmg/ddl166
McGuffin P, 2003, ARCH GEN PSYCHIAT, V60, P497, DOI 10.1001/archpsyc.60.5.497
MCGUFFIN P, 1989, BRIT J PSYCHIAT, V155, P294
McMahon FJ, 2010, NAT GENET, V42, P128, DOI 10.1038/ng.523
McMahon FJ, 2010, NAT GENET, V43, P5
MELTZER HL, 1991, BIOL PSYCHIAT, V30, P1071, DOI 10.1016/0006-3223(91)90178-O
Mondimore FM, 2005, INT REV PSYCHIATR, V17, P39, DOI 10.1080/09540260500068216
Muglia P, 2008, MOL PSYCHIAT
Paez-Gonzalez P, 2011, NEURON, V71, P61, DOI 10.1016/j.neuron.2011.05.029
Ripke S, 2011, NAT GENET, V43, P969, DOI 10.1038/ng.940
Schulze TG, 2008, MOL PSYCHIATR, V14, P487
Scott LJ, 2009, P NATL ACAD SCI USA, V106, P7501, DOI 10.1073/pnas.0813386106
Sklar P, 2011, NAT GENET, V43, P977, DOI 10.1038/ng.943
Sklar P, 2008, MOL PSYCHIATR, V13, P558, DOI 10.1038/sj.mp.4002151
Splawski I, 2004, CELL, V119, P19, DOI 10.1016/j.cell.2004.09.011
Splawski I, 2006, J BIOL CHEM, V281, P22085, DOI 10.1074/jbc.M603316200
Tabangin Meredith E, 2009, BMC Proc, V3 Suppl 7, pS41, DOI 10.1186/1753-6561-3-S7-S41
Takata A, 2011, AM J MED GENET B, V156B, P312, DOI 10.1002/ajmg.b.31164
Tesli M, 2011, AM J MED GENET B, V156B, P969, DOI 10.1002/ajmg.b.31244
Van den Bogaert A, 2006, ARCH GEN PSYCHIAT, V63, P1103, DOI 10.1001/archpsyc.63.10.1103
Weber H, 2011, NEUROPSYCHOPHARMACOL, V36, P2076, DOI 10.1038/npp.2011.98
Westfall P. H., 1993, RESAMPLING BASED MUL
Wigginton JE, 2005, AM J HUM GENET, V76, P887, DOI 10.1086/429864
Williams HJ, 2011, HUM MOL GENET, V20, P387, DOI 10.1093/hmg/ddq471
WINOKUR G, 1995, ARCH GEN PSYCHIAT, V52, P367
WINOKUR G, 1993, AM J PSYCHIAT, V150, P1176
Wittchen HU, 1999, METHODS PSYCHIAT RES, P59
World Health Organization, 2007, INT STAT CLASS DIS R, V10th
Wray NR, 2012, MOL PSYCHIATR, V17, P36, DOI 10.1038/mp.2010.109
Xia ZG, 2005, NAT REV NEUROSCI, V6, P267, DOI 10.1038/nrn1647
Zhang XD, 2005, NEURON, V45, P11, DOI 10.1016/j.neuron.2004.12.014
ZHANG Y, 1989, PSYCHIAT RES, V27, P267, DOI 10.1016/0165-1781(89)90142-X
NR 53
TC 4
Z9 4
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0022-3956
J9 J PSYCHIATR RES
JI J. Psychiatr. Res.
PD AUG
PY 2012
VL 46
IS 8
BP 973
EP 979
DI 10.1016/j.jpsychires.2012.04.017
PG 7
WC Psychiatry
SC Psychiatry
GA 980AF
UT WOS:000306865300001
PM 22647524
ER
PT J
AU Camarena, B
Gonzalez, L
Hernandez, S
Caballero, A
AF Camarena, Beatriz
Gonzalez, Laura
Hernandez, Sandra
Caballero, Alejandro
TI SLC6A4 rare variant associated with eating disorders in Mexican patients
SO JOURNAL OF PSYCHIATRIC RESEARCH
LA English
DT Letter
ID AUTISM
C1 [Camarena, Beatriz; Hernandez, Sandra] Inst Nacl Psiquiatria Ramon de la Fuente Muniz, Dept Genet Psiquiatr, Mexico City, DF, Mexico.
[Gonzalez, Laura; Caballero, Alejandro] Inst Nacl Psiquiatria Ramon de la Fuente Muniz, Clin Trastornos Alimentarios, Mexico City, DF, Mexico.
RP Camarena, B (reprint author), Inst Nacl Psiquiatria Ramon de la Fuente, Calz Mexico Xochimilco 101, Mexico City 14370, DF, Mexico.
EM camare@imp.edu.mx
CR Barrett JC, 2005, BIOINFORMATICS, V21, P263, DOI 10.1093/bioinformatics/bth457
Bulik CM, 2009, INT J EAT DISORDER, V40, P552
Caballero AR, 2003, INT J EAT DISORDER, V34, P136, DOI 10.1002/eat.10150
Glatt CE, 2001, NAT GENET, V27, P435, DOI 10.1038/86948
Ozaki N, 2003, MOL PSYCHIATR, V8, P933, DOI 10.1038/sj.mp.4001365
Prasad HC, 2009, PHILOS T R SOC B, V364, P163, DOI 10.1098/rstb.2008.0143
Prasad HC, 2005, P NATL ACAD SCI USA, V102, P11545, DOI 10.1073/pnas.0501432102
Sutcliffe JS, 2005, AM J HUM GENET, V77, P265, DOI 10.1086/432648
NR 8
TC 0
Z9 0
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0022-3956
J9 J PSYCHIATR RES
JI J. Psychiatr. Res.
PD AUG
PY 2012
VL 46
IS 8
BP 1106
EP 1107
DI 10.1016/j.jpsychires.2012.04.011
PG 2
WC Psychiatry
SC Psychiatry
GA 980AF
UT WOS:000306865300020
PM 22622072
ER
PT J
AU Lee, C
Walter, G
Cleary, M
AF Lee, Cindy
Walter, Garry
Cleary, Michelle
TI Communicating with Children with Autism Spectrum Disorder and Their
Families A Practical Introduction
SO JOURNAL OF PSYCHOSOCIAL NURSING AND MENTAL HEALTH SERVICES
LA English
DT Article
ID SOCIAL-SKILLS; ADOLESCENTS; LIFE
AB Impaired communication and social interaction are symptoms central to autism spectrum disorder (ASD). Children or young people with ASD have varied intellectual ability, learning difficulty, and needs. For caregivers and health care professionals providing care to children with ASD, many challenges are encountered in everyday conversations. Enhanced knowledge of the spectrum and understanding the child or young person with ASD may improve conversation and social experiences. This article provides a practical introduction for health professionals seeking to improve their interaction with young people with ASD. Fictional vignettes, in which children with ASD are seeking care and support are presented, followed by discussion on communicating with children with ASD. Copyright (C) SLACK Incorporated
C1 [Cleary, Michelle] Natl Univ Singapore, Yong Loo Lin Sch Med, Alice Lee Ctr Nursing Studies, Clin Res Ctr, Singapore 117597, Singapore.
[Walter, Garry] Univ Sydney, N Ryde, NSW, Australia.
[Walter, Garry] No Sydney Local Hlth Dist, Child Serv, N Ryde, NSW, Australia.
[Walter, Garry] No Sydney Local Hlth Dist, Adolescent Mental Hlth Serv, N Ryde, NSW, Australia.
RP Cleary, M (reprint author), Natl Univ Singapore, Yong Loo Lin Sch Med, Alice Lee Ctr Nursing Studies, Clin Res Ctr, Level 2,Block MD11,10 Med Dr, Singapore 117597, Singapore.
EM michelle_cleary@nuhs.edu.sg
CR Brooks R., 2004, CURRENT PAEDIAT, V14, P208, DOI 10.1016/j.cupe.2004.02.002
Burgess S, 2010, LANG SPEECH HEAR SER, V41, P474, DOI 10.1044/0161-1461(2010/09-0007)
Charman T., 2008, PSYCHIATRY, V7, P331, DOI 10.1016/j.mppsy.2008.05.015
Chiang HM, 2009, RES AUTISM SPECT DIS, V3, P214, DOI 10.1016/j.rasd.2008.06.002
Dawson G, 2011, CURR OPIN PEDIATR, V23, P616, DOI 10.1097/MOP.0b013e32834cf082
Dawson G, 2004, DEV PSYCHOL, V40, P271, DOI 10.1037/0012-1649.40.2.271
Delmolino L, 2012, J AUTISM DEV DISORD, V42, P1197, DOI 10.1007/s10803-011-1298-6
Duffy C, 2011, RES AUTISM SPECT DIS, V5, P977, DOI 10.1016/j.rasd.2010.12.005
Flynn L, 2012, RES AUTISM SPECT DIS, V6, P431, DOI 10.1016/j.rasd.2011.06.016
Iverson JM, 2007, J AUTISM DEV DISORD, V37, P158, DOI 10.1007/s10803-006-0339-z
Krauss MW, 2003, MENT RETARD, V41, P329, DOI 10.1352/0047-6765(2003)41<329:ATSMCF>2.0.CO;2
Laushey KM, 2000, J AUTISM DEV DISORD, V30, P183, DOI 10.1023/A:1005558101038
Levetown M, 2008, PEDIATRICS, V121, pE1441, DOI 10.1542/peds.2008-0565
Maljaars J, 2011, J COMMUN DISORD, V44, P601, DOI 10.1016/j.jcomdis.2011.07.004
Nilsen ES, 2011, DEV REV, V31, P55, DOI 10.1016/j.dr.2011.07.001
O'Hearn K, 2008, DEV PSYCHOPATHOL, V20, P1103, DOI 10.1017/S0954579408000527
Stuart M, 2009, RES AUTISM SPECT DIS, V3, P86, DOI 10.1016/j.rasd.2008.04.006
Theoharides TC, 2009, EXPERT OPIN PHARMACO, V10, P2127, DOI 10.1517/14656560903107789
Wetherby AM, 2007, J AUTISM DEV DISORD, V37, P960, DOI 10.1007/s10803-006-0237-4
Yates K, 2009, PAEDIAT CHILD HLTH, V19, P55, DOI DOI 10.1016/J.PAED.2008.10.010
NR 20
TC 1
Z9 1
PU SLACK INC
PI THOROFARE
PA 6900 GROVE RD, THOROFARE, NJ 08086 USA
SN 0279-3695
J9 J PSYCHOSOC NURS MEN
JI J. Psychosoc. Nurs. Ment. Health Serv.
PD AUG
PY 2012
VL 50
IS 8
BP 40
EP 44
DI 10.3928/02793695-20120703-06
PG 5
WC Nursing
SC Nursing
GA 002QA
UT WOS:000308546000011
PM 22801823
ER
PT J
AU Plastow, M
AF Plastow, Michael
TI 'Theory of mind' II: difficulties and critiques
SO AUSTRALASIAN PSYCHIATRY
LA English
DT Article
DE autism; cognitive; false-belief tasks; second-person; 'theory of mind'
AB Objective: 'Theory of mind' will be further examined firstly by looking at the experimental situation that was used to put forward this notion. A fundamental difficulty regarding the failure of 'theory of mind' to account for the misunderstandings of everyday life will be discussed. Other difficulties in the experimental conceptualisation of this notion will then be studied. Critiques that have previously been made of 'theory of mind' will also be examined.
Conclusions: 'Theory of mind' proposes an ideal of limpid understanding of the other. It is argued here that this notion of mind-reading is belied by its failure in our everyday lives. The experimental results by which this notion was proposed are neither sensitive nor specific. It is argued that there is also a fundamental error in this conception and its experimental design due to assessing a second-person phenomenon by a third-person method. Critiques of 'theory of mind' emphasise the epistemological difficulties and the fact that it is a poor explanation for the interactions of non-autistic subjects.
RP Plastow, M (reprint author), Alfred CAMHS, 999 Nepean Hwy, Moorabbin, Vic 3189, Australia.
EM m.plastow@alfred.org.au
CR BARONCOHEN S, 1985, COGNITION, V21, P37, DOI 10.1016/0010-0277(85)90022-8
Baron-Cohen Simon, 1995, MINDBLINDNESS ESSAY
Freud S, 1960, STANDARD EDITION COM, VVI
Gallagher S., 2004, PHILOS PSYCHIAT PSYC, V11, P199, DOI [10.1353/ppp.2004.0063, DOI 10.1353/PPP.2004.0063]
Happe Francesca, 1995, AUTISM INTRO PSYCHOL
Lacan Jacques, 2006, ECRITS 1 COMPLETE ED, P82
Plastow M, 2012, AUSTRALAS PSYCHIATRY, V20, P199, DOI 10.1177/1039856212447882
Richard Gipps, 2004, PHILOS PSYCHIAT PSYC, V11, P195, DOI 10.1353/ppp.2004.0065
Shankar S. G., 2004, PHILOS PSYCHIAT PSYC, V11, P219, DOI 10.1353/ppp.2004.0068
NR 9
TC 3
Z9 3
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1039-8562
J9 AUSTRALAS PSYCHIATRY
JI Australas. Psychiatry
PD AUG
PY 2012
VL 20
IS 4
BP 291
EP 294
DI 10.1177/1039856212449670
PG 4
WC Psychiatry
SC Psychiatry
GA 996KG
UT WOS:000308084700006
PM 22767933
ER
PT J
AU Simonoff, E
AF Simonoff, Emily
TI Autism spectrum disorder: prevalence and cause may be bound together
SO BRITISH JOURNAL OF PSYCHIATRY
LA English
DT Editorial Material
ID POPULATION; COHORT
AB Autism has been in the forefront of science and public concern because of reported increases in its prevalence. Changing diagnostic practice and improved identification explain some of this rise, but there may also be a true increase. Aetiological research needs to include environmental factors to understand the causes of autism.
C1 Inst Psychiat, Dept Child & Adolescent Psychiat, London SE5 8AF, England.
RP Simonoff, E (reprint author), Inst Psychiat, Dept Child & Adolescent Psychiat, De Crespigny Pk, London SE5 8AF, England.
EM emily.simonoff@kcl.ac.uk
RI Simonoff, Emily/B-7593-2011
CR BAILEY A, 1995, PSYCHOL MED, V25, P63
Baird G, 2006, LANCET, V368, P210, DOI 10.1016/S0140-6736(06)69041-7
Baron-Cohen S, 2010, PROG BRAIN RES, V186, P167, DOI 10.1016/B978-0-444-53630-3.00011-7
Bejerot S, 2012, BRIT J PSYCHIAT, V201, P116, DOI 10.1192/bjp.bp.111.097899
Kim YS, 2011, AM J PSYCHIAT, V168, P904, DOI 10.1176/appi.ajp.2011.10101532
Magnusson C, 2012, BRIT J PSYCHIAT, V201, P109, DOI 10.1192/bjp.bp.111.095125
Mandy W, 2011, AUTISM RES, V4, P121, DOI 10.1002/aur.178
Mattila ML, 2011, J AM ACAD CHILD ADOL, V50, P583
Robinson EB, 2011, ARCH GEN PSYCHIAT, V68, P1113, DOI 10.1001/archgenpsychiatry.2011.119
Rutter M, 1999, J CHILD PSYCHOL PSYC, V40, P537, DOI 10.1017/S0021963099003935
Stoltenberg C, 2010, MOL PSYCHIATR, V15, P676, DOI 10.1038/mp.2009.143
NR 11
TC 2
Z9 2
PU ROYAL COLLEGE OF PSYCHIATRISTS
PI LONDON
PA BRITISH JOURNAL OF PSYCHIATRY 17 BELGRAVE SQUARE, LONDON SW1X 8PG,
ENGLAND
SN 0007-1250
J9 BRIT J PSYCHIAT
JI Br. J. Psychiatry
PD AUG
PY 2012
VL 201
IS 2
BP 88
EP 89
DI 10.1192/bjp.bp.111.104703
PG 2
WC Psychiatry
SC Psychiatry
GA 987NI
UT WOS:000307423800002
PM 22859574
ER
PT J
AU Magnusson, C
Rai, D
Goodman, A
Lundberg, M
Idring, S
Svensson, A
Koupil, I
Serlachius, E
Dalman, C
AF Magnusson, Cecilia
Rai, Dheeraj
Goodman, Anna
Lundberg, Michael
Idring, Selma
Svensson, Anna
Koupil, Ilona
Serlachius, Eva
Dalman, Christina
TI Migration and autism spectrum disorder: population-based study
SO BRITISH JOURNAL OF PSYCHIATRY
LA English
DT Article
ID PERVASIVE DEVELOPMENTAL DISORDERS; PERINATAL RISK-FACTORS;
INFANTILE-AUTISM; EPIDEMIOLOGY; PREVALENCE; IMMIGRANTS; CHILDHOOD;
ETHNICITY; CHILDREN; STRESS
AB Background
Migration has been implicated as a risk factor for autism, but evidence is limited and inconsistent.
Aims
To investigate the relationship between parental migration status and risk of autism spectrum disorder, taking into consideration the importance of region of origin, timing of migration and possible discrepancies in associations between autism subtypes.
Method
Record-linkage study within the total child population of Stockholm County between 2001 and 2007. Individuals with high- and low-functioning autism were defined as having autism spectrum disorder with and without comorbid intellectual disability, and ascertained via health and habilitation service registers.
Results
In total, 4952 individuals with autism spectrum disorder were identified, comprising 2855 children with high-functioning autism and 2097 children with low-functioning autism. Children of migrant parents were at increased risk of low-functioning autism (odds ratio (OR) = 1.5, 95% CI 1.3-1.7); this risk was highest when parents migrated from regions with a low human development index, and peaked when migration occurred around pregnancy (OR=2.3, 95% CI 1.7-3.0). A decreased risk of high-functioning autism was observed in children of migrant parents, regardless of area of origin or timing of migration. Parental age, income or obstetric complications did not fully explain any of these associations.
Conclusions
Environmental factors associated with migration may contribute to the development of autism presenting with comorbid intellectual disability, especially when acting in utero. High- and low-functioning autism may have partly different aetiologies, and should be studied separately.
C1 [Magnusson, Cecilia; Rai, Dheeraj; Lundberg, Michael; Idring, Selma; Svensson, Anna; Dalman, Christina] Karolinska Inst, Dept Publ Hlth Sci, Div Publ Hlth Epidemiol, S-17176 Stockholm, Sweden.
[Rai, Dheeraj] Univ Bristol, Sch Social & Community Med, Acad Unit Psychiat, Bristol BS8 1TH, Avon, England.
[Goodman, Anna] London Sch Hyg & Trop Med, Fac Epidemiol & Populat Hlth, London WC1, England.
[Goodman, Anna; Koupil, Ilona] Stockholm Univ, Karolinska Inst, Ctr Hlth Equ Studies CHESS, S-10691 Stockholm, Sweden.
[Lundberg, Michael] Stockholm Cty Council, Neuropsychiat Resource Team SE Stockholm, Stockholm, Sweden.
[Idring, Selma; Serlachius, Eva] Karolinska Inst, Div Psychiat, Dept Clin Neurosci, S-17176 Stockholm, Sweden.
RP Magnusson, C (reprint author), Karolinska Inst, Dept Publ Hlth Sci, Div Publ Hlth Epidemiol, S-17176 Stockholm, Sweden.
EM cecilia.magnusson@ki.se
RI Serlachius, Eva/E-8956-2013
OI Serlachius, Eva/0000-0001-7115-6422
FU Stockholm County Council; Swedish Council for Working Life and Social
Research [2007-2064]; Severn Deanery, Bristol, UK
FX The Stockholm County Council, the Swedish Council for Working Life and
Social Research (grant no. 2007-2064). D.R. is supported by a clinical
lecturer award funded by the Severn Deanery, Bristol, UK.
CR American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th
Axen M., 2010, ADHD LINDRIG UTVECKL
BARAK Y, 1995, AM J PSYCHIAT, V152, P798
Barnevik-Olsson M, 2010, DEV MED CHILD NEUROL, V52, P1167, DOI 10.1111/j.1469-8749.2010.03812.x
Begeer S, 2009, J AUTISM DEV DISORD, V39, P142, DOI 10.1007/s10803-008-0611-5
Beydoun H, 2008, PAEDIATR PERINAT EP, V22, P438, DOI 10.1111/j.1365-3016.2008.00951.x
Bhasin TK, 2007, J AUTISM DEV DISORD, V37, P667, DOI 10.1007/s10803-006-0194-y
Bourque F, 2011, PSYCHOL MED, V41, P897, DOI 10.1017/S0033291710001406
Bradby H, 2007, SOC SCI MED, V65, P2413, DOI 10.1016/j.socscimed.2007.07.025
Centers for Disease Control and Prevention, 2009, MMWR-MORBID MORTAL W, V58, P1
Croen LA, 2002, J AUTISM DEV DISORD, V32, P217, DOI 10.1023/A:1015405914950
Dealberto MJ, 2011, ACTA PSYCHIAT SCAND, V123, P339, DOI 10.1111/j.1600-0447.2010.01662.x
Fassaert T, 2009, SOC PSYCH PSYCH EPID, V44, P208, DOI 10.1007/s00127-008-0418-x
Fombonne E, 2009, PEDIATR RES, V65, P591, DOI 10.1203/PDR.0b013e31819e7203
Fombonne E, 2003, J AUTISM DEV DISORD, V33, P365, DOI 10.1023/A:1025054610557
GILLBERG C, 1987, BRIT J PSYCHIAT, V150, P856, DOI 10.1192/bjp.150.6.856
Gillberg IC, 1996, J INTELL DISABIL RES, V40, P24, DOI 10.1111/j.1365-2788.1996.tb00599.x
Haglund NGS, 2011, AUTISM, V15, P163, DOI 10.1177/1362361309353614
Haper J, 1976, Med J Aust, V1, P299
Hultman CM, 2011, MOL PSYCHIATR, V16, P1203, DOI 10.1038/mp.2010.121
Hultman CM, 2002, EPIDEMIOLOGY, V13, P417, DOI 10.1097/01.EDE.0000016968.14007.E6
Kamer A, 2004, SOC PSYCH PSYCH EPID, V39, P141, DOI 10.1007/s00127-004-0696-x
Keen DV, 2010, BRIT J PSYCHIAT, V196, P274, DOI 10.1192/bjp.bp.109.065490
Khashan AS, 2008, ARCH GEN PSYCHIAT, V65, P146, DOI 10.1001/archgenpsychiatry.2007.20
Kinney DK, 2008, NEUROSCI BIOBEHAV R, V32, P1519, DOI 10.1016/j.neubiorev.2008.06.004
Larson T, 2010, BMC PSYCHIATRY, V10, DOI 10.1186/1471-244X-10-1
Lauritsen MB, 2005, J CHILD PSYCHOL PSYC, V46, P963, DOI 10.1111/j.1469-7610.2004.00391.x
Lauritsen MB, 2010, J AUTISM DEV DISORD, V40, P139, DOI 10.1007/s10803-009-0818-0
Levy SE, 2009, LANCET, V374, P1627, DOI 10.1016/S0140-6736(09)61376-3
Lichtenstein P, 2010, AM J PSYCHIAT, V167, P1357, DOI 10.1176/appi.ajp.2010.10020223
Maimburg RD, 2006, ACTA PSYCHIAT SCAND, V114, P257, DOI 10.1111/j.1600-0447.2006.00805.x
Morgan C, 2010, SCHIZOPHRENIA BULL, V36, P655, DOI 10.1093/schbul/sbq051
Rutter M, 2005, ACTA PAEDIATR, V94, P2, DOI 10.1080/08035250410023124
Szatmari P, 2007, INT REV PSYCHIATR, V19, P483, DOI 10.1080/09540260701563619
Williams K, 2008, CHILD CARE HLTH DEV, V34, P249, DOI 10.1111/j.1365-2214.2007.00796.x
WING L, 1980, BRIT J PSYCHIAT, V137, P410, DOI 10.1192/bjp.137.5.410
Witwer AN, 2008, J AUTISM DEV DISORD, V38, P1611, DOI 10.1007/s10803-008-0541-2
NR 37
TC 21
Z9 21
PU ROYAL COLLEGE OF PSYCHIATRISTS
PI LONDON
PA BRITISH JOURNAL OF PSYCHIATRY 17 BELGRAVE SQUARE, LONDON SW1X 8PG,
ENGLAND
SN 0007-1250
J9 BRIT J PSYCHIAT
JI Br. J. Psychiatry
PD AUG
PY 2012
VL 201
IS 2
BP 109
EP 115
DI 10.1192/bjp.bp.111.095125
PG 7
WC Psychiatry
SC Psychiatry
GA 987NI
UT WOS:000307423800009
PM 22361019
ER
PT J
AU Bejerot, S
Eriksson, JM
Bonde, S
Canstrom, K
Humble, MB
Eriksson, E
AF Bejerot, Susanne
Eriksson, Jonna M.
Bonde, Sabina
Canstrom, Kjell
Humble, Mats B.
Eriksson, Elias
TI The extreme male brain revisited: gender coherence in adults with autism
spectrum disorder
SO BRITISH JOURNAL OF PSYCHIATRY
LA English
DT Article
ID FETAL TESTOSTERONE; FUNCTIONING AUTISM; SEX-DIFFERENCES; LENGTH RATIOS;
VOICE PITCH; OXYTOCIN; VASOPRESSIN; CHALLENGE; CHILDREN; BEHAVIOR
AB Background
The 'extreme male brain' theory suggests that autism spectrum disorder (ASD) is an extreme variant of male intelligence. However, somewhat paradoxically, many individuals with ASD display androgynous physical features regardless of gender.
Aims
To assess physical measures, supposedly related to androgen influence, in adults with and without ASD.
Method
Serum hormone levels, anthropometry, the ratio of 2nd to 4th digit length (2D:4D) and psychiatric symptomatology were measured in 50 adults with high-functioning ASD and age- and gender-matched neurotypical controls. Photographs of face and body, as well as voice recordings, were obtained and assessed with respect to gender coherence, blindly and independently, by eight assessors.
Results
Women with ASD had higher total and bioactive testosterone levels, less feminine facial features and a larger head circumference than female controls. Men in the ASD group were assessed as having less masculine body characteristics and voice quality, and displayed higher (i.e. less masculine) 2D:4D ratios, but similar testosterone levels to controls. Androgynous facial features correlated strongly and positively with autistic traits measured with the Autism-Spectrum Quotient in the total sample. In males and females with ASD dehydroepiandrosterone sulfate did not decrease with age, in contrast to the control group.
Conclusions
Women with ASD had elevated testosterone levels and several masculinised characteristics compared with controls, whereas men with ASD displayed several feminised characteristics. Our findings suggest that ASD, rather than being characterised by masculinisation in both genders, may constitute a gender defiant disorder.
C1 [Bejerot, Susanne] St Goran Hosp, VUB KogNUS, No Stockholm Psychiat, SE-11281 Stockholm, Sweden.
[Bejerot, Susanne; Eriksson, Jonna M.; Canstrom, Kjell] Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden.
[Canstrom, Kjell] Karolinska Inst, Div Obstet & Gynaecol, Dept Woman & Child Hlth, Stockholm, Sweden.
[Humble, Mats B.] Univ Uppsala Hosp, Dept Clin Neurosci, Uppsala, Sweden.
[Eriksson, Elias] Univ Gothenburg, Inst Neurosci & Physiol, Dept Pharmacol, Gothenburg, Sweden.
RP Bejerot, S (reprint author), St Goran Hosp, VUB KogNUS, No Stockholm Psychiat, SE-11281 Stockholm, Sweden.
EM susanne.bejerot@ki.se
RI Humble, Mats/B-3119-2013
FU St Goran Foundation; Swedish Society of Medicine; Thuring Foundation
FX This study was supported by the St Goran Foundation, The Swedish Society
of Medicine and the Thuring Foundation.
CR American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th
Apicella CL, 2007, BIOLOGY LETT, V3, P682, DOI 10.1098/rsbl.2007.0410
Asperger H., 1991, AUTISM ASPERGER SYND, P37, DOI 10.1017/CBO9780511526770.002
Auyeung B, 2009, BRIT J PSYCHOL, V100, P1, DOI 10.1348/000712608X311731
Baron-Cohen S, 2001, J AUTISM DEV DISORD, V31, P5, DOI 10.1023/A:1005653411471
Baron-Cohen Simon, 2005, Cogn Neuropsychiatry, V10, P77, DOI 10.1080/13546800344000336
Baron-Cohen S, 2002, TRENDS COGN SCI, V6, P248, DOI 10.1016/S1364-6613(02)01904-6
Baron-Cohen S, 2001, J CHILD PSYCHOL PSYC, V42, P241, DOI 10.1017/S0021963001006643
Bejerot S, 2011, INT J ANDROL, V34, pE350, DOI 10.1111/j.1365-2605.2011.01149.x
Brown WM, 2002, ARCH SEX BEHAV, V31, P123, DOI 10.1023/A:1014091420590
Carter CS, 2007, BEHAV BRAIN RES, V176, P170, DOI 10.1016/j.bbr.2006.08.025
Dabbs JM, 1999, PERS INDIV DIFFER, V27, P801, DOI 10.1016/S0191-8869(98)00272-4
De Bruin EI, 2009, AUTISM, V13, P511, DOI 10.1177/1362361309335720
de Vries ALC, 2010, J AUTISM DEV DISORD, V40, P930, DOI 10.1007/s10803-010-0935-9
Evans S, 2006, BIOL PSYCHOL, V72, P160, DOI 10.1016/j.biopsycho.2005.09.003
Evans S, 2008, PHYSIOL BEHAV, V93, P783, DOI 10.1016/j.physbeh.2007.11.033
Geier DA, 2007, NEUROENDOCRINOL LETT, V28, P565
Herbert MR, 2005, NEUROSCIENTIST, V11, P417, DOI 10.1177/0091270005278866
Hines M, 2010, TRENDS COGN SCI, V14, P448, DOI 10.1016/j.tics.2010.07.005
Ingudomnuku E, 2007, HORM BEHAV, V51, P597, DOI 10.1016/j.yhbeh.2007.02.001
Insel TR, 1995, ADV EXP MED BIOL, V395, P227
Insel TR, 2010, NEURON, V65, P768, DOI 10.1016/j.neuron.2010.03.005
Okten A, 2002, EARLY HUM DEV, V70, P47, DOI 10.1016/S0378-3782(02)00073-7
Knickmeyer R, 2005, J CHILD PSYCHOL PSYC, V46, P198, DOI 10.1111/j.1469-7610.2004.00349.x
Knickmeyer RC, 2006, J CHILD NEUROL, V21, P825, DOI 10.2310/7010.2006.00213
LORD C, 1989, J AUTISM DEV DISORD, V19, P185, DOI 10.1007/BF02211841
Maninger N, 2009, FRONT NEUROENDOCRIN, V30, P65, DOI 10.1016/j.yfrne.2008.11.002
Manning JT, 2001, DEV MED CHILD NEUROL, V43, P160, DOI 10.1017/S0012162201000317
Mills JL, 2007, CLIN ENDOCRINOL, V67, P230, DOI 10.1111/j.1365-2265.2007.02868.x
Rahman Q, 2005, PSYCHONEUROENDOCRINO, V30, P382, DOI 10.1016/j.psyneuen.2004.10.006
Ruta L, 2011, PSYCHONEUROENDOCRINO, V36, P1154, DOI 10.1016/j.psyneuen.2011.02.007
Ryden E, 2008, CLIN NEUROPSYCHIATRY, V5, P13
Sala M, 2011, BIOL PSYCHIAT, V69, P875, DOI 10.1016/j.biopsych.2010.12.022
Sheehan DV, 1998, J CLIN PSYCHIAT, V59, P22, DOI 10.4088/JCP.09m05305whi
Strous RD, 2005, EUR NEUROPSYCHOPHARM, V15, P305, DOI 10.1016/j.euroneuro.2004.12.004
Sutton-Tyrrell K, 2010, AM J EPIDEMIOL, V171, P1203, DOI 10.1093/aje/kwq049
TORDJMAN S, 1995, J AUTISM DEV DISORD, V25, P295, DOI 10.1007/BF02179290
Zitzmann M, 2001, EUR J ENDOCRINOL, V144, P183, DOI 10.1530/eje.0.1440183
NR 38
TC 26
Z9 26
PU ROYAL COLLEGE OF PSYCHIATRISTS
PI LONDON
PA BRITISH JOURNAL OF PSYCHIATRY 17 BELGRAVE SQUARE, LONDON SW1X 8PG,
ENGLAND
SN 0007-1250
J9 BRIT J PSYCHIAT
JI Br. J. Psychiatry
PD AUG
PY 2012
VL 201
IS 2
BP 116
EP 123
DI 10.1192/bjp.bp.111.097899
PG 8
WC Psychiatry
SC Psychiatry
GA 987NI
UT WOS:000307423800010
PM 22500012
ER
PT J
AU Thambirajah, MS
AF Thambirajah, M. S.
TI Autism Spectrum Disorders through the Lifespan
SO BRITISH JOURNAL OF PSYCHIATRY
LA English
DT Book Review
C1 [Thambirajah, M. S.] British Journal Psychiat, London SW1X 8PG, England.
RP Thambirajah, MS (reprint author), British Journal Psychiat, 17 Belgrave Sq, London SW1X 8PG, England.
EM bjp@rcpsych.ac.uk
CR TANTAM D, 2011, AUTISM SPECTRUM DISO
NR 1
TC 0
Z9 0
PU ROYAL COLLEGE OF PSYCHIATRISTS
PI LONDON
PA BRITISH JOURNAL OF PSYCHIATRY 17 BELGRAVE SQUARE, LONDON SW1X 8PG,
ENGLAND
SN 0007-1250
J9 BRIT J PSYCHIAT
JI Br. J. Psychiatry
PD AUG
PY 2012
VL 201
IS 2
BP 163
EP 164
PG 2
WC Psychiatry
SC Psychiatry
GA 987NI
UT WOS:000307423800024
ER
PT J
AU Thambirajah, MS
AF Thambirajah, M. S.
TI Autism Spectrum Disorders
SO BRITISH JOURNAL OF PSYCHIATRY
LA English
DT Book Review
C1 [Thambirajah, M. S.] British Journal Psychiat, London SW1X 8PG, England.
RP Thambirajah, MS (reprint author), British Journal Psychiat, 17 Belgrave Sq, London SW1X 8PG, England.
EM bjp@rcpsych.ac.uk
CR Amaral D., 2011, AUTISM SPECTRUM DISO
NR 1
TC 0
Z9 0
PU ROYAL COLLEGE OF PSYCHIATRISTS
PI LONDON
PA BRITISH JOURNAL OF PSYCHIATRY 17 BELGRAVE SQUARE, LONDON SW1X 8PG,
ENGLAND
SN 0007-1250
J9 BRIT J PSYCHIAT
JI Br. J. Psychiatry
PD AUG
PY 2012
VL 201
IS 2
BP 163
EP 164
PG 2
WC Psychiatry
SC Psychiatry
GA 987NI
UT WOS:000307423800023
ER
PT J
AU Johansson, CF
AF Johansson, C. F.
TI Infectious Behavior: Brain-immune Connections in Autism, Schizophrenia,
and Depression
SO BRITISH JOURNAL OF PSYCHIATRY
LA English
DT Book Review
EM doctorfreddie@gmail.com
CR Patterson PH, 2011, INFECTIOUS BEHAVIOR: BRAIN-IMMUNE CONNECTIONS IN AUTISM, SCHIZOPHRENIA, AND DEPRESSION, P1
NR 1
TC 0
Z9 0
PU ROYAL COLLEGE OF PSYCHIATRISTS
PI LONDON
PA BRITISH JOURNAL OF PSYCHIATRY 17 BELGRAVE SQUARE, LONDON SW1X 8PG,
ENGLAND
SN 0007-1250
J9 BRIT J PSYCHIAT
JI Br. J. Psychiatry
PD AUG
PY 2012
VL 201
IS 2
BP 164
EP 165
DI 10.1192/bjp.bp.112.113829
PG 2
WC Psychiatry
SC Psychiatry
GA 987NI
UT WOS:000307423800026
ER
PT J
AU Maras, KL
Bowler, DM
AF Maras, Katie L.
Bowler, Dermot M.
TI Context reinstatement effects on eyewitness memory in autism spectrum
disorder
SO BRITISH JOURNAL OF PSYCHOLOGY
LA English
DT Article
ID SCHOOL-AGE-CHILDREN; COGNITIVE INTERVIEW; FREE-RECALL;
ASPERGERS-SYNDROME; EPISODIC MEMORY; OLDER-ADULTS
AB The Cognitive Interview is among the most widely accepted forms of police interviewing techniques; however, it is ineffective for witnesses with autism spectrum disorder (ASD). One of its main components involves mentally reinstating the internal and external context that was experienced at encoding. We report evidence showing that it is the mental reinstatement instructions in the absence of any physical cues that individuals with ASD find difficult. In more supported conditions where they physically return to the same environment in which they learnt the material, they recall as much as their typical counterparts. Our findings indicate that recall in ASD is aided by context, but only when supported by the physical environment. These findings have important implications for investigative interviewing procedures for witnesses with ASD.
C1 [Maras, Katie L.] City Univ London, Dept Psychol, Autism Res Grp, London EC1V 0HB, England.
RP Maras, KL (reprint author), City Univ London, Dept Psychol, Autism Res Grp, London EC1V 0HB, England.
RI Maras, Katie/F-9283-2013
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
ANDERSON RC, 1978, J VERB LEARN VERB BE, V17, P1, DOI 10.1016/S0022-5371(78)90485-1
Baron-Cohen S, 2001, J AUTISM DEV DISORD, V31, P5, DOI 10.1023/A:1005653411471
BOON J, 1994, PSYCHOL CRIME LAW, V1, P59, DOI 10.1080/10683169408411936
Bowler DM, 2004, J AUTISM DEV DISORD, V34, P533, DOI 10.1007/s10803-004-2548-7
Bowler DM, 2008, J AUTISM DEV DISORD, V38, P104, DOI 10.1007/s10803-007-0366-4
Chalfonte BL, 1996, MEM COGNITION, V24, P403, DOI 10.3758/BF03200930
CHRISTIANSON SA, 1992, PSYCHOL BULL, V112, P284, DOI 10.1037//0033-2909.112.2.284
Constantino JN, 2003, ARCH GEN PSYCHIAT, V60, P524, DOI 10.1001/archpsyc.60.5.524
Crane L, 2008, J AUTISM DEV DISORD, V38, P498, DOI 10.1007/s10803-007-0420-2
Darmala SR, 2010, AUTISM RES, V3, P273
DAVIES G, 1985, CRIM JUSTICE BEHAV, V12, P209, DOI 10.1177/0093854885012002004
Fernandez A., 2001, PSICOLOGICA, V22, P253
Fisher R. P., 1992, MEMORY ENHANCING TEC
Gabig CS, 2008, LANG SPEECH HEAR SER, V39, P498, DOI 10.1044/0161-1461(2008/07-0023)
Gaigg SB, 2008, NEUROPSYCHOLOGIA, V46, P983, DOI 10.1016/j.neuropsychologia.2007.11.011
GEISELMAN RE, 1984, J POLICE SCI ADMIN, V12, P74
GEISELMAN RE, 1988, J POLICE SCI ADMIN, V16, P236
Henkel LA, 1998, J EXP PSYCHOL GEN, V127, P251, DOI 10.1037//0096-3445.127.3.251
HERMELIN B, 1967, BRIT J PSYCHOL, V58, P213
Home-Office, 2007, ACHIEV BEST EVID CRI
Joseph RM, 2005, DEV NEUROPSYCHOL, V27, P361, DOI 10.1207/s15326942dn2703_4
Kanner L, 1943, NERV CHILD, V2, P217
Klein SB, 1999, SOC COGNITION, V17, P413, DOI 10.1521/soco.1999.17.4.413
Lind SE, 2010, J ABNORM PSYCHOL, V119, P896, DOI 10.1037/a0020631
Lord C., 1999, AUTISM DIAGNOSTIC OB
Maras KL, 2010, J AUTISM DEV DISORD, V40, P1350, DOI 10.1007/s10803-010-0997-8
Memon A, 2010, PSYCHOL PUBLIC POL L, V16, P340, DOI 10.1037/a0020518
Memon A, 1997, BRIT J PSYCHOL, V88, P179
Milne R, 1999, PSYCHOL CRIME LAW, V5, P81, DOI 10.1080/10683169908414995
MINSHEW NJ, 1992, J CLIN EXP NEUROPSYC, V14, P749, DOI 10.1080/01688639208402860
Mottron L, 1998, MEMORY, V6, P593
Mundy P., 1994, UNDERSTANDING OTHER, P181
SMITH SM, 1979, J EXP PSYCHOL-HUM L, V5, P460, DOI 10.1037/0278-7393.5.5.460
TAGERFLUSBERG H, 1991, BRIT J DEV PSYCHOL, V9, P417
TULVING E, 1985, CAN PSYCHOL, V26, P1, DOI 10.1037/h0080017
TULVING E, 1973, PSYCHOL REV, V80, P352, DOI 10.1037/h0020071
Wechsler D, 1997, WECHSLER ADULT INTEL, V3rd
Williams DL, 2006, NEUROPSYCHOLOGY, V20, P21, DOI 10.1037/0894-4105.20.1.21
Wright AM, 2007, MEMORY, V15, P17, DOI 10.1080/09658210601047351
NR 40
TC 4
Z9 4
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0007-1269
J9 BRIT J PSYCHOL
JI Br. J. Psychol.
PD AUG
PY 2012
VL 103
BP 330
EP 342
DI 10.1111/j.2044-8295.2011.02077.x
PN 3
PG 13
WC Psychology, Multidisciplinary
SC Psychology
GA 974BQ
UT WOS:000306405200004
PM 22804700
ER
PT J
AU Guo, TY
Chen, H
Liu, B
Ji, WD
Yang, C
AF Guo, Tianyou
Chen, Hong
Liu, Bing
Ji, Weidong
Yang, Chuang
TI Methylenetetrahydrofolate Reductase Polymorphisms C677T and Risk of
Autism in the Chinese Han Population
SO GENETIC TESTING AND MOLECULAR BIOMARKERS
LA English
DT Article
ID SINGLE NUCLEOTIDE POLYMORPHISMS; PERVASIVE DEVELOPMENTAL DISORDERS;
SPECTRUM DISORDERS; GENE POLYMORPHISMS; OXIDATIVE STRESS; ASSOCIATION;
CHILDREN; MTHFR; PREVALENCE; INDIVIDUALS
AB Causes of autism are still unknown. Some studies have shown that autism might be associated with metabolic abnormalities in the folate/homocysteine pathway, which is involved in DNA methylation, thus altering gene expression. The association between the methylenetetrahydrofolate reductase (MTHFR) gene C677T polymorphisms and the risk of autism is still controversial and ambiguous. The purpose of this study was to examine the effect of the MTHFR C677T polymorphism on the autism risk in the Chinese Han population. A population-based case-control study was conducted in 186 children with autism and 186 controls. The MTHFR C677T polymorphisms were determined by using a polymerase chain reaction-restriction fragment length polymorphism assay. The frequency of genotype MTHFR 677TT in children with autism (16.1%) was significantly higher (odds ratio [OR] = 2.04; 95% confidence interval [CI] = 1.07, 3.89; p = 0.03] than those in controls (8.6%). When stratifying by select-item scores on the Autism Diagnostic Interview-Revised, it was found that children with current overactivity had a significantly higher frequency of the MTHFR 677TT genotype (OR = 2.77, 95% CI = 1.17, 6.60; p = 0.02) than those without. This study suggested that MTHFR C677T is a risk factor of autism in Chinese Han children.
C1 [Chen, Hong; Yang, Chuang] WenZhou Med Coll, Dept Psychiat, Affiliated Hosp 1, Wenzhou 325000, Zhejiang, Peoples R China.
[Guo, Tianyou] Shenzhen Univ, Dept Psychol, Normal Coll, Shenzhen, Guangdong, Peoples R China.
[Liu, Bing] WenZhou Med Coll, Dept Psychol, Wenzhou 325000, Zhejiang, Peoples R China.
[Ji, Weidong] Changning Mental Hlth Ctr, Dept Psychiat, Shanghai, Peoples R China.
RP Yang, C (reprint author), WenZhou Med Coll, Dept Psychiat, Affiliated Hosp 1, 2 FuXue Lane, Wenzhou 325000, Zhejiang, Peoples R China.
EM cyang186@hotmail.com
CR Algasham A, 2009, GENET TEST MOL BIOMA, V13, P817, DOI 10.1089/gtmb.2009.0019
Ali A, 2009, GENET TEST MOL BIOMA, V13, P355, DOI 10.1089/gtmb.2008.0115
Chakrabarti S, 2001, JAMA-J AM MED ASSOC, V285, P3093, DOI 10.1001/jama.285.24.3093
Charman T, 2002, EUR CHILD ADOLES PSY, V11, P249, DOI 10.1007/s00787-002-0297-8
Demirel Y, 2011, GENET TEST MOL BIOMA, V15, P785, DOI 10.1089/gtmb.2011.0044
dos Santos PAC, 2010, PSYCHIAT GENET, V20, P187, DOI 10.1097/YPG.0b013e32833a2220
Freitag CM, 2007, MOL PSYCHIATR, V12, P2, DOI 10.1038/sj.mp.4001896
Gadow KD, 2010, J AUTISM DEV DISORD, V40, P1139, DOI [10.1007/s10803-010-0961-7, 10.1007/s10803-010-0959-1]
Gadow KD, 2010, EUR J NEUROSCI, V32, P1058, DOI 10.1111/j.1460-9568.2010.07382.x
Gava MM, 2011, GENET TEST MOL BIOMA, V15, P153, DOI 10.1089/gtmb.2010.0128
Gebril OH, 2011, DIS MARKERS, V31, P289, DOI 10.3233/DMA-2011-0830
Goin-Kochel RP, 2009, AUTISM RES, V2, P98, DOI 10.1002/aur.70
Guerini FR, 2011, J NEUROIMMUNOL, V230, P135, DOI 10.1016/j.jneuroim.2010.10.019
Guerini FR, 2011, PHARMACOL RES, V64, P283, DOI 10.1016/j.phrs.2011.03.015
James SJ, 2006, AM J MED GENET B, V141B, P947, DOI 10.1002/ajmg.b.30366
Karathanasis NV, 2011, GENET TEST MOL BIOMA, V15, P5, DOI 10.1089/gtmb.2010.0083
Kim HW, 2009, AM J MED GENET B, V150B, P300, DOI 10.1002/ajmg.b.30798
Lauritsen MB, 2001, ACTA PSYCHIAT SCAND, V103, P411, DOI 10.1034/j.1600-0447.2001.00086.x
Li XP, 2010, PSYCHIAT GENET, V20, P113, DOI 10.1097/YPG.0b013e32833a216f
Liu XD, 2011, J AUTISM DEV DISORD, V41, P938, DOI 10.1007/s10803-010-1120-x
Liu XX, 2010, J HUM GENET, V55, P137, DOI 10.1038/jhg.2009.140
LORD C, 1989, J AUTISM DEV DISORD, V19, P185, DOI 10.1007/BF02211841
LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
Mansoor A, 2009, GENET TEST MOL BIOMA, V13, P521, DOI 10.1089/gtmb.2009.0012
Mohammad NS, 2009, PSYCHIAT GENET, V19, P171, DOI 10.1097/YPG.0b013e32832cebd2
Mukhopadhyay R, 2009, GENET TEST MOL BIOMA, V13, P861, DOI 10.1089/gtmb.2009.0063
Pasca SP, 2009, J CELL MOL MED, V13, P4229, DOI 10.1111/j.1582-4934.2008.00463.x
Rogers EJ, 2008, MED HYPOTHESES, V71, P406, DOI 10.1016/j.mehy.2008.04.013
Sadiq MF, 2011, GENET TEST MOL BIOMA, V15, P51, DOI 10.1089/gtmb.2010.0057
Schmidt RJ, 2011, EPIDEMIOLOGY, V22, P476, DOI 10.1097/EDE.0b013e31821d0e30
Sousa I, 2010, MOL AUTISM, V1, DOI 10.1186/2040-2392-1-7
Vasilopoulos Y, 2011, GENET TEST MOL BIOMA, V15, P613, DOI 10.1089/gtmb.2010.0256
Weiss LA, 2009, EXPERT REV MOL DIAGN, V9, P795, DOI [10.1586/erm.09.59, 10.1586/ERM.09.59]
Wilcken B, 2003, J MED GENET, V40, P619, DOI 10.1136/jmg.40.8.619
Yang PC, 2010, NEUROPSYCHOBIOLOGY, V62, P104, DOI 10.1159/000315441
Yang SY, 2010, NEUROSCI LETT, V479, P197, DOI 10.1016/j.neulet.2010.05.050
NR 36
TC 7
Z9 8
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1945-0265
J9 GENET TEST MOL BIOMA
JI Genet. Test. Mol. Biomark.
PD AUG
PY 2012
VL 16
IS 8
BP 968
EP 973
DI 10.1089/gtmb.2012.0091
PG 6
WC Biochemistry & Molecular Biology; Genetics & Heredity
SC Biochemistry & Molecular Biology; Genetics & Heredity
GA 999IN
UT WOS:000308303200026
PM 22775456
ER
PT J
AU Pearson, DA
Aman, MG
Arnold, LE
Lane, DM
Loveland, KA
Santos, CW
Casat, CD
Mansour, R
Jerger, SW
Ezzell, S
Factor, P
Vanwoerden, S
Ye, E
Narain, P
Cleveland, LA
AF Pearson, Deborah A.
Aman, Michael G.
Arnold, L. Eugene
Lane, David M.
Loveland, Katherine A.
Santos, Cynthia W.
Casat, Charles D.
Mansour, Rosleen
Jerger, Susan W.
Ezzell, Sarah
Factor, Perry
Vanwoerden, Salome
Ye, Enstin
Narain, Punya
Cleveland, Lynne A.
TI High Concordance of Parent and Teacher Attention-Deficit/Hyperactivity
Disorder Ratings in Medicated and Unmedicated Children with Autism
Spectrum Disorders
SO JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY
LA English
DT Article
ID PERVASIVE DEVELOPMENTAL DISORDERS; EMOTIONAL-PROBLEMS; BEHAVIOR
PROBLEMS; YOUNG-PEOPLE; ADHD; HYPERACTIVITY; AGREEMENT; SYMPTOMS;
SAMPLE; CLASSIFICATION
AB Objective: Parent and teacher ratings of core attention-deficit/hyperactivity disorder (ADHD) symptoms, as well as behavioral and emotional problems commonly comorbid with ADHD, were compared in children with autism spectrum disorders (ASD).
Method: Participants were 86 children (66 boys; mean: age = 9.3 years, intelligence quotient [IQ] = 84) who met American Psychiatric Association Diagnostic and Statistical Manual of Mental Disorders, 4th ed. (DSM-IV) criteria for an ASD on the Autism Diagnostic Interview-Revised (ADI-R) and the Autism Diagnostic Observation Schedule (ADOS). Parent and teacher behavioral ratings were compared on the Conners' Parent and Teacher Rating Scales (CPRS-R; CTRS-R). The degree to which age, ASD subtype, severity of autistic symptomatology, and medication status mediated this relationship was also examined.
Results: Significant positive correlations between parent and teacher ratings suggest that a child's core ADHD symptoms-as well as closely related externalizing symptoms-are perceived similarly by parents and teachers. With the exception of oppositional behavior, there was no significant effect of age, gender, ASD subtype, or autism severity on the relationship between parent and teacher ratings. In general, parents rated children as having more severe symptomatology than did teachers. Patterns of parent and teacher ratings were highly correlated, both for children who were receiving medication, and for children who were not.
Conclusions: Parents and teachers perceived core symptoms of ADHD and closely-related externalizing problems in a similar manner, but there is less agreement on ratings of internalizing problems (e.g., anxiety). The clinical implication of these findings is that both parents and teachers provide important behavioral information about children with ASD. However, when a clinician is unable to access teacher ratings (e.g., during school vacations), parent ratings can provide a reasonable estimate of the child's functioning in these domains in school. As such, parent ratings can be reliably used to make initial diagnostic and treatment decisions (e.g., medication treatment) regarding ADHD symptoms in children with ASDs.
C1 [Pearson, Deborah A.; Loveland, Katherine A.; Santos, Cynthia W.; Mansour, Rosleen; Ezzell, Sarah; Vanwoerden, Salome; Ye, Enstin; Cleveland, Lynne A.] Univ Texas Houston, Sch Med, Dept Psychiat & Behav Sci, Houston, TX 77054 USA.
[Aman, Michael G.; Arnold, L. Eugene] Ohio State Univ, Nisonger Ctr, Columbus, OH 43210 USA.
[Lane, David M.; Factor, Perry; Narain, Punya] Rice Univ, Houston, TX USA.
[Casat, Charles D.] Carolina NeuroSolut LC, Dept Psychol, Charleston, NC USA.
[Jerger, Susan W.] Univ Texas Dallas, Sch Behav & Brain Sci, Dallas, TX 75230 USA.
RP Pearson, DA (reprint author), Univ Texas Houston, Sch Med, Dept Psychiat & Behav Sci, 1941 E Rd, Houston, TX 77054 USA.
EM Deborah.A.Pearson@uth.tmc.edu
FU Curemark LLC; Biomarin Pharmaceuticals; Bristol-Myers Squibb; Confluence
Pharmaceutica; Forest Research; Hoffman LaRoche; Johnson Johnson;
Supernus Pharmaceutica; CureMark; Lilly; NIMH; Shire; Eli Lilly;
Novartis; Abbott Laboratories; National Institute of Mental Health
(NIMH) [MH072263]
FX Dr. Pearson and Ms. Mansour have received travel reimbursement from the
Forest Research Institute, and research support from Curemark LLC. Dr.
Pearson has also served as a consultant to Curemark LLC and to United
BioSource Corporation. Michael Aman, Ph.D. has received research
contracts, consulted with, or served on advisory boards of Biomarin
Pharmaceuticals, Bristol-Myers Squibb, Confluence Pharmaceutica, Forest
Research, Hoffman LaRoche, Johnson & Johnson, and Supernus
Pharmaceutica. Dr. Arnold has received research funding from CureMark,
Lilly, NIMH, and Shire, has consulted to Organon, NIDA, Sigma Tau, and
Targacept, and has served on advisory boards for AstraZeneca, Biomarin,
Novartis, Noven, and Seaside Therapeutics. Dr. Santos and Ms. Ezzell
have received research support from Curemark LLC. Dr. Casat has received
research funding from Eli Lilly, Novartis, and Abbott Laboratories. Dr.
Jerger has served as a consultant to Pearson Assessments/Psychological
Corporation. The other authors report no biomedical financial interests
or potential conflicts of interest.This study was funded by grant number
MH072263 from the National Institute of Mental Health (NIMH).
CR ACHENBACH TM, 1987, PSYCHOL BULL, V101, P213, DOI 10.1037/0033-2909.101.2.213
Amador-Campos JA, 2006, J PSYCHOPATHOL BEHAV, V28, P23, DOI 10.1007/s10862-006-4538-x
Aman MG, 2005, J CHILD ADOL PSYCHOP, V15, P116, DOI 10.1089/cap.2005.15.116
Conners C. K., 1997, CONNERS RATING SCALE
Constantino JN, 2007, J AM ACAD CHILD PSY, V46, P1668, DOI 10.1097/chi.0b013e318157cb23
De Los Reyes A, 2005, PSYCHOL BULL, V131, P483, DOI 10.1037/0033-2909.131.4.483
DINNEBEIL LA, 1994, TOP EARLY CHILD SPEC, V14, P1
Drabick DAG, 2007, J AM ACAD CHILD PSY, V46, P92, DOI 10.1097/01.chi.0000242245.00174.90
Faraone SV, 2005, EUR CHILD ADOLES PSY, V14, P20, DOI 10.1007/s00787-005-0415-5
Gadow KD, 2004, J AUTISM DEV DISORD, V34, P379, DOI 10.1023/B:JADD.0000037415.21458.93
Gadow KD, 2006, J AUTISM DEV DISORD, V36, P271, DOI 10.1007/s10803-005-0060-3
Guerts HM, 2008, NEUROPSYCHOLOGIA, V46, P3030
Guttmann-Steinmetz S, 2009, J AUTISM DEV DISORD, V9, P976
Hartman CA, 2007, J ABNORM CHILD PSYCH, V35, P536, DOI 10.1007/s10802-007-9110-y
Kanne SM, 2009, J AUTISM DEV DISORD, V39, P856, DOI 10.1007/s10803-009-0694-7
Lecavalier L, 2006, J AUTISM DEV DISORD, V36, P1101, DOI 10.1007/s10803-006-0147-5
Lecavalier L, 2009, J AUTISM DEV DISORD, V39, P278, DOI 10.1007/s10803-008-0622-2
Lecavalier L, 2006, J INTELL DISABIL RES, V50, P172, DOI 10.1111/j.1365-2788.2005.00732.x
Lee DO, 2006, J CHILD ADOL PSYCHOP, V16, P737, DOI 10.1089/cap.2006.16.737
Leyfer OT, 2006, J AUTISM DEV DISORD, V36, P849, DOI 10.1007/s10803-006-0123-0
Lord C., 2001, AUTISM DIAGNOSTIC OB
Loveland K. A., 2005, HDB AUTISM PERVASIVE, P247
Mitsis EM, 2000, J AM ACAD CHILD PSY, V39, P308, DOI 10.1097/00004583-200003000-00012
Pearson DA, 2006, CHILD NEUROPSYCHOL, V12, P321, DOI 10.1080/092970406006464847
Pearson DA, 1997, ATTENTION DEV PSYCHO, P205
Reiersen AM, 2007, J CHILD PSYCHOL PSYC, V48, P464, DOI 10.1111/j.1469-7610.2006.01720.x
Reiersen AM, 2008, DEVELOPMENTAL PSYCHOPATHOLOGY AND WELLNESS: GENETIC AND ENVIRONMENTAL INFLUENCES, P191
Roid G. H., 2003, STANFORD BINET INTEL
Rowland AS, 2008, J ABNORM CHILD PSYCH, V36, P731, DOI 10.1007/s10802-007-9203-7
Rutter M., 2003, AUTISM DIAGNOSTIC IN
Simonoff E, 2009, J AM ACAD CHILD ADOL, V47, P921
Sinzig J, 2008, ACTA NEUROPSYCHIATR, V20, P207, DOI 10.1111/j.1601-5215.2008.00292.x
STANGER C, 1993, J CLIN CHILD PSYCHOL, V22, P107, DOI 10.1207/s15374424jccp2201_11
Sullivan Jeremy R, 2007, J Atten Disord, V11, P398, DOI 10.1177/1087054707299399
SZATMARI P, 1994, J AUTISM DEV DISORD, V24, P703, DOI 10.1007/BF02172281
Tasse MJ, 2000, AM J MENT RETARD, V105, P252, DOI 10.1352/0895-8017(2000)105<0252:CPATRO>2.0.CO;2
NR 36
TC 6
Z9 6
PU MARY ANN LIEBERT INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1044-5463
J9 J CHILD ADOL PSYCHOP
JI J. Child Adolesc. Psychopharmacol.
PD AUG
PY 2012
VL 22
IS 4
BP 284
EP 291
DI 10.1089/cap.2011.0067
PG 8
WC Pediatrics; Pharmacology & Pharmacy; Psychiatry
SC Pediatrics; Pharmacology & Pharmacy; Psychiatry
GA 994MB
UT WOS:000307933800005
PM 22849541
ER
PT J
AU Storch, EA
May, JE
Wood, JJ
Jones, AM
De Nadai, AS
Lewin, AB
Arnold, EB
Murphy, TK
AF Storch, Eric A.
May, Jill Ehrenreich
Wood, Jeffrey J.
Jones, Anna M.
De Nadai, Alessandro S.
Lewin, Adam B.
Arnold, Elysse B.
Murphy, Tanya K.
TI Multiple Informant Agreement on the Anxiety Disorders Interview Schedule
in Youth with Autism Spectrum Disorders
SO JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY
LA English
DT Article
ID PERVASIVE DEVELOPMENTAL DISORDERS; PSYCHOPATHOLOGY RATING-SCALES;
STRUCTURED INTERVIEW; INTERRATER AGREEMENT; DIAGNOSTIC INTERVIEW;
CHILDREN; PARENT; SYMPTOMS; RELIABILITY; SYMPTOMATOLOGY
AB Objective: The purpose of this study was to examine child, parent, and clinician's consensus agreement on the Anxiety Disorders Interview Schedule, Child and Parent versions (ADIS-C/P) in a sample of children and adolescents with autism spectrum disorders (ASD).
Method: Youth with ASD (n = 85; age range = 7-17 years) and their parents were each administered the ADIS-C/P by a trained clinician. Consensus diagnoses were determined in a clinical conference using best estimate procedures that incorporated all available information.
Results: Children and youth with ASD diagnoses generally showed poor diagnostic agreement with parents and clinical consensus, whereas parents showed good-to-excellent diagnostic agreement with clinical consensus diagnoses. Diagnostic agreement between parents and consensus was moderated by the specific ASD diagnosis. Otherwise, the pattern of relationships did not systematically differ as a function of age or externalizing comorbidity.
Conclusions: These data suggest that parent and youth agreement regarding the presence of clinical levels of anxiety is markedly poor among youth with ASD. Additionally, clinicians are likely to base their diagnostic impressions on parent report, placing minimal emphasis on child report.
C1 [Storch, Eric A.; Jones, Anna M.; Lewin, Adam B.; Arnold, Elysse B.; Murphy, Tanya K.] Univ S Florida, Dept Pediat, St Petersburg, FL 33701 USA.
[Storch, Eric A.; Lewin, Adam B.; Murphy, Tanya K.] Univ S Florida, Dept Psychiat, St Petersburg, FL 33701 USA.
[Storch, Eric A.; De Nadai, Alessandro S.] Univ S Florida, Dept Psychol, St Petersburg, FL 33701 USA.
[May, Jill Ehrenreich] Univ Miami, Dept Psychol, Miami, FL USA.
[Wood, Jeffrey J.] Univ Calif Los Angeles, Dept Educ, Los Angeles, CA USA.
[Wood, Jeffrey J.] Univ Calif Los Angeles, Dept Psychiat & Behav Sci, Los Angeles, CA 90024 USA.
RP Storch, EA (reprint author), Univ S Florida, Dept Pediat, 800 6th St S,Box 7523, St Petersburg, FL 33701 USA.
EM estorch@health.usf.edu
RI Storch, Eric/I-4935-2012; Lewin, Adam/A-9832-2013
FU National Institute of Child Health and Human Development
[5R34HD065274-02, HD65270-01, HD65284-01]; All Children's Hospital
Research Foundation; University of South Florida Office of Research and
Innovation Established Researcher Grant Program
FX This article was supported by grants from the National Institute of
Child Health and Human Development to Drs. Storch, Ehrenreich May, and
Wood (5R34HD065274-02, HD65270-01, and HD65284-01 and grants to Dr.
Storch from the All Children's Hospital Research Foundation and the
University of South Florida Office of Research and Innovation
Established Researcher Grant Program.
CR Ben-Sasson A, 2008, J CHILD PSYCHOL PSYC, V49, P817, DOI 10.1111/j.1469-7610.2008.01899.x
CDC (Cent. Dis. Control Prev.), 2009, MMWR-MORBID MORTAL W, V58, P1
Choudhury MS, 2003, J AM ACAD CHILD PSY, V42, P957, DOI 10.1097/01.CHI.0000046898.27264.A2
COHEN J, 1960, EDUC PSYCHOL MEAS, V20, P37, DOI 10.1177/001316446002000104
Crozier M, 2011, HANDBOOK OF CHILD AND ADOLESCENT ANXIETY DISORDERS, P7, DOI 10.1007/978-1-4419-7784-7_2
Dadds MR, 1998, J ABNORM CHILD PSYCH, V26, P311, DOI 10.1023/A:1022610702439
Derr RE, 2009, PERFORMING EXACT LOG
Flanery R. C., 1990, EYES CHILD OBTAINING, P57
Fombonne E, 2005, J CLIN PSYCHIAT, V66, P3
Grills AE, 2003, J AM ACAD CHILD PSY, V42, P30, DOI 10.1097/01.CHI.0000024899.60748.EE
Hope TL, 1999, J PSYCHOPATHOL BEHAV, V21, P349, DOI 10.1023/A:1022124900328
JENSEN PS, 1988, J AM ACAD CHILD PSY, V27, P451, DOI 10.1097/00004583-198807000-00013
Jensen PS, 1999, J AM ACAD CHILD PSY, V38, P1569, DOI 10.1097/00004583-199912000-00019
JENSEN PS, 1988, J AM ACAD CHILD PSY, V27, P442, DOI 10.1097/00004583-198807000-00012
Kanne SM, 2009, J AUTISM DEV DISORD, V39, P856, DOI 10.1007/s10803-009-0694-7
Kelly AB, 2008, J ABNORM CHILD PSYCH, V36, P1069, DOI 10.1007/s10802-008-9234-8
Kendall PC, 2000, CHILD AND ADOLESCENT THERAPY: COGNITIVE-BEHAVIORAL PROCEDURES, SECOND EDITION, P235
Kendall PC, 1998, J ABNORM CHILD PSYCH, V26, P27, DOI 10.1023/A:1022630706189
Kim YS, 2011, AM J PSYCHIAT, V168, P904, DOI 10.1176/appi.ajp.2011.10101532
Kogan MD, 2009, PEDIATRICS, V124, P1395, DOI 10.1542/peds.2009-1522
KURDEK LA, 1987, J CONSULT CLIN PSYCH, V55, P712
LECKMAN JF, 1982, ARCH GEN PSYCHIAT, V39, P879
Leyfer OT, 2006, J AUTISM DEV DISORD, V36, P849, DOI 10.1007/s10803-006-0123-0
Lord C, 1997, J AUTISM DEV DISORD, V27, P501, DOI 10.1023/A:1025873925661
Lord C., 1999, AUTISM DIAGNOSTIC OB
LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
MANNUZZA S, 1989, ARCH GEN PSYCHIAT, V46, P1093
Mildenberger K, 2001, EUR CHILD ADOLES PSY, V10, P248
Muris P, 1998, J ANXIETY DISORD, V12, P387, DOI 10.1016/S0887-6185(98)00022-X
ORVASCHEL H, 1981, J AM ACAD CHILD PSY, V20, P112, DOI 10.1016/S0002-7138(09)60721-4
RAPEE RM, 1994, J AM ACAD CHILD PSY, V33, P984, DOI 10.1097/00004583-199409000-00008
RUPP, 2002, J AM ACAD CHILD ADOL, V41, P1061
Silverman W. K., 1996, ANXIETY DISORDERS IN
SILVERMAN WK, 1992, J AM ACAD CHILD PSY, V31, P117, DOI 10.1097/00004583-199201000-00018
Storch EA, 2008, J AM ACAD CHILD PSY, V47, P583, DOI 10.1097/CHI.0b013e31816774b1
Sukhodolsky DG, 2008, J ABNORM CHILD PSYCH, V36, P117, DOI 10.1007/s10802-007-9165-9
Wood JJ, 2010, CLIN PSYCHOL-SCI PR, V17, P281, DOI 10.1111/j.1468-2850.2010.01220.x
Wood JW, 2002, TLS-TIMES LIT SUPPL, P31
NR 38
TC 18
Z9 18
PU MARY ANN LIEBERT INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1044-5463
J9 J CHILD ADOL PSYCHOP
JI J. Child Adolesc. Psychopharmacol.
PD AUG
PY 2012
VL 22
IS 4
BP 292
EP 299
DI 10.1089/cap.2011.0114
PG 8
WC Pediatrics; Pharmacology & Pharmacy; Psychiatry
SC Pediatrics; Pharmacology & Pharmacy; Psychiatry
GA 994MB
UT WOS:000307933800006
PM 22856332
ER
PT J
AU Niwa, T
Aida, N
Tanaka, Y
Tanaka, M
Shiomi, M
Machida, J
AF Niwa, Tetsu
Aida, Noriko
Tanaka, Yukichi
Tanaka, Mio
Shiomi, Masae
Machida, Jiro
TI Scurvy in a Child With Autism: Magnetic Resonance Imaging and
Pathological Findings
SO JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY
LA English
DT Article
DE scurvy; magnetic resonance imaging; autistic disorder; child; pathology
AB We present a case of scurvy in a 6-year-old boy with autism and an unbalanced diet. The patient was admitted with difficulties in walking. Magnetic resonance imaging findings of the thigh showed diffuse signal abnormality in the bone marrow, periosteum, and the femoral muscle. A biopsy specimen of the femur showed hematoma, proliferative fibroblasts, and few collagen fibers, which suggested a deficiency of vitamin C. Although recurrent periosteal hematoma may be suggestive of scurvy, this finding was subtle in the current case. It is important to be aware of this rare disease because it is easily cured with vitamin C supplementation.
C1 [Niwa, Tetsu; Aida, Noriko] Kanagawa Childrens Med Ctr, Dept Radiol, Minami Ku, Yokohama, Kanagawa 2328555, Japan.
[Tanaka, Yukichi; Tanaka, Mio] Kanagawa Childrens Med Ctr, Dept Pathol, Minami Ku, Yokohama, Kanagawa 2328555, Japan.
[Shiomi, Masae] Kanagawa Childrens Med Ctr, Dept Hematooncol Regenerat Med, Minami Ku, Yokohama, Kanagawa 2328555, Japan.
[Machida, Jiro] Kanagawa Childrens Med Ctr, Dept Orthoped Surg, Minami Ku, Yokohama, Kanagawa 2328555, Japan.
RP Niwa, T (reprint author), Kanagawa Childrens Med Ctr, Dept Radiol, Minami Ku, 2-138-4 Mutsukawa, Yokohama, Kanagawa 2328555, Japan.
EM tniwa@kcmc.jp
CR Choi SW, 2007, KOREAN J RADIOL, V8, P443, DOI 10.3348/kjr.2007.8.5.443
Duggan CP, 2007, NEW ENGL J MED, V357, P392
Fain O, 2005, JOINT BONE SPINE, V72, P124, DOI 10.1016/j.jbspin.2004.01.007
Heymann WR, 2007, J AM ACAD DERMATOL, V57, P358, DOI 10.1016/j.jaad.2007.03.008
Karthiga S, 2008, RHEUMATOLOGY, V47, P1109, DOI 10.1093/rheumatology/ken160
Olmedo JM, 2006, INT J DERMATOL, V45, P909, DOI 10.1111/j.1365-4632.2006.02844.x
Ratanachu-Ek Suntaree, 2003, J Med Assoc Thai, V86 Suppl 3, pS734
Shore R, 2007, CAFFEYS PEDIAT DIAGN, P2739
Weinstein M, 2001, PEDIATRICS, V108, DOI 10.1542/peds.108.3.e55
NR 9
TC 4
Z9 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1077-4114
J9 J PEDIAT HEMATOL ONC
JI J. Pediatr. Hematol. Oncol.
PD AUG
PY 2012
VL 34
IS 6
BP 484
EP 487
DI 10.1097/MPH.0b013e318236c519
PG 4
WC Oncology; Hematology; Pediatrics
SC Oncology; Hematology; Pediatrics
GA 999YW
UT WOS:000308353000028
PM 22258350
ER
PT J
AU Gordijn, B
ten Have, H
AF Gordijn, Bert
ten Have, Henk
TI Ethics of autism
SO MEDICINE HEALTH CARE AND PHILOSOPHY
LA English
DT Editorial Material
C1 [Gordijn, Bert; ten Have, Henk] Dublin City Univ, Inst Eth, Dublin 9, Ireland.
RP Gordijn, B (reprint author), Dublin City Univ, Inst Eth, Dublin 9, Ireland.
EM bert.gordijn@dcu.ie
CR Asperger H, 1944, ARCH PSYCHIAT NERVEN, V117, P76, DOI 10.1007/BF01837709
Barnbaum D.R., 2008, ETHICS AUTISM THEM B
Barnes RE., MED HLTH CARE PHILOS
Jaarsma P, MED HLTH CARE PHILOS
Kanner L, 1943, NERV CHILD, V2, P217
Sanders S.J., 2011, NEURON, V70, P863
NR 6
TC 0
Z9 0
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 1386-7423
J9 MED HEALTH CARE PHIL
JI Med. Health Care Philos.
PD AUG
PY 2012
VL 15
IS 3
BP 253
EP 254
DI 10.1007/s11019-012-9422-8
PG 2
WC Ethics; History & Philosophy Of Science
SC Social Sciences - Other Topics; History & Philosophy of Science
GA 986ZL
UT WOS:000307386100001
PM 22688721
ER
PT J
AU Barnes, RE
McCabe, H
AF Barnes, R. Eric
McCabe, Helen
TI Should we welcome a cure for autism? A survey of the arguments
SO MEDICINE HEALTH CARE AND PHILOSOPHY
LA English
DT Article
DE Autism; Ethics; Cure; Disability; Bioethics; Medical ethics
ID MORAL AGENCY; EMPATHY; CHILDREN
AB Substantial research efforts have been devoted to developing a cure for autism, but some advocates of people with autism claim that these efforts are misguided and even harmful. They claim that there is nothing wrong with people with autism, so there is nothing to cure. Others argue that autism is a serious and debilitating disorder and that a cure for autism would be a wonderful medical breakthrough. Our goal in this essay is to evaluate what assumptions underlie each of these positions. We evaluate the arguments made on each side, reject those that are implausible and then highlight the key assumptions of those that remain.
C1 [Barnes, R. Eric] Hobart & William Smith Coll, Dept Philosophy, Geneva, NY 14456 USA.
[McCabe, Helen] Hobart & William Smith Coll, Dept Educ, Geneva, NY 14456 USA.
RP Barnes, RE (reprint author), Hobart & William Smith Coll, Dept Philosophy, Geneva, NY 14456 USA.
EM barnes@hws.edu; mccabe@hws.edu
CR Baggs A., 2008, WORLD I WANT LIVE
Barnbaum D.R., 2008, ETHICS AUTISM THEM B
Benn P., 1999, PHILOS PSYCHIAT PSYC, V6, P29
Beveridge C.J., 2001, YOU WILL DREAM NEW D, P81
Biklen D., 2005, AUTISM MYTH PERSON A
Bondy A, 2001, BEHAV MODIF, V25, P725, DOI 10.1177/0145445501255004
Cohen D., 2001, OUR JOURNEY YOU WILL, P85
Cohen N., 2008, COMMUNICATION 0415
Cohen S., 2002, TARGETING AUTISM
Dancy J., 1997, READING PARFIT
Dawson M., 2004, MISBEHAVIOUR BEHAVIO
Donnelly J.A., 2000, FOCUS AUTISM OTHER D, V15, P196, DOI 10.1177/108835760001500402
Durand V.M., 1993, BEHAVIOUR CHANGE, V10, P197
Feinberg J., 1984, MORAL LIMITS CRIMINA, V1- 4
Filipek PA, 1999, J AUTISM DEV DISORD, V29, P439, DOI 10.1023/A:1021943802493
Grandin T., 1996, EMERGENCE LABELED AU
Grandin Temple, 2006, THINKING PICTURES MY, Vrev
Harmon A., 2004, NAMIBIAN 0112
HOBSON RP, 1993, PHILOS PSYCHOL, V6, P227, DOI 10.1080/09515089308573090
Jary DJJ, 1991, HARPER COLLINS DICT
Kennett J, 2002, PHILOS QUART, V52, P340, DOI 10.1111/1467-9213.00272
Klein S.D., 2001, YOU WILL DREAM NEW D
Krahn T, 2007, J ETHICS MENTAL HLTH, V2, P1
Krahn T, 2009, J THEOR SOC BEHAV, V39, P145, DOI 10.1111/j.1468-5914.2009.00402.x
LOVAAS OI, 1987, J CONSULT CLIN PSYCH, V55, P3, DOI 10.1037/0022-006X.55.1.3
Naseef R. A., 2001, SPECIAL CHILDREN CHA
Nussbaum M., 1993, THE QUALITY OF LIFE
Nussbaum M. C., 2007, FRONTIERS JUSTICE DI
Rachels J., 2004, ELEMENTS MORAL PHILO
Rawls J, 1971, THEORY JUSTICE
Roberts D., 2008, ABC NEWS 0519
Saner E., 2007, GUARDIAN 0529
Schrandt JA, 2009, J APPL BEHAV ANAL, V42, P17, DOI 10.1901/jaba.2009.42-17
Senator S., 2005, MAKING PEACE AUTISM
Shapiro J., 2006, AUTISM MOVEMENT SEEK
Shoemaker D, 2007, ETHICS, V118, P70, DOI 10.1086/521280
Shoemaker Sydney, 1984, PERSONAL IDENTITY
Sigafoos J, 1996, BEHAV MODIF, V20, P60, DOI 10.1177/01454455960201003
Sinclair J., 1993, OUR VOICE AUTISM NET
Sinclair J., 2005, AUTISM NETWORK INT D
Treffert DA, 2009, PHILOS T R SOC B, V364, P1351, DOI 10.1098/rstb.2008.0326
Trivedi B, 2005, NEW SCI, V186, P36
WERTHEIMER ALAN, 1987, COERCION
NR 43
TC 0
Z9 0
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 1386-7423
J9 MED HEALTH CARE PHIL
JI Med. Health Care Philos.
PD AUG
PY 2012
VL 15
IS 3
BP 255
EP 269
DI 10.1007/s11019-011-9339-7
PG 15
WC Ethics; History & Philosophy Of Science
SC Social Sciences - Other Topics; History & Philosophy of Science
GA 986ZL
UT WOS:000307386100002
PM 21837546
ER
PT J
AU Jaarsma, P
Gelhaus, P
Welin, S
AF Jaarsma, Pier
Gelhaus, Petra
Welin, Stellan
TI Living the categorical imperative: autistic perspectives on lying and
truth telling-between Kant and care ethics
SO MEDICINE HEALTH CARE AND PHILOSOPHY
LA English
DT Article
DE High-functioning autism; Autobiographies; Truthfulness; Moral
responsibilities; Moral education; Kant; Ethics of care
ID EMOTIONAL EMPATHY
AB Lying is a common phenomenon amongst human beings. It seems to play a role in making social interactions run more smoothly. Too much honesty can be regarded as impolite or downright rude. Remarkably, lying is not a common phenomenon amongst normally intelligent human beings who are on the autism spectrum. They appear to be 'attractively morally innocent' and seem to have an above average moral conscientious objection against deception. In this paper, the behavior of persons with autism with regard to deception and truthfulness will be discussed in the light of two different ethical theories, illustrated by fragments from autobiographies of persons with autism. A systemizing 'Kantian' and an empathizing 'ethics of care' perspective reveal insights on high-functioning autism, truthfulness and moral behavior. Both perspectives are problematic from the point of view of a moral agent with autism. High-functioning persons with autism are, generally speaking, strong systemizes and weak empathizers. Particularly, they lack 'cognitive empathy' which would allow them to understand the position of the other person. Instead, some tend to invent a set of rules that makes their behavior compatible with the expectations of others. From a Kantian point of view, the autistic tendency to always tell the truth appears praiseworthy and should not be changed, though it creates problems in the social life of persons with autism. From a care ethics perspective, on the other hand, a way should be found to allow the high-functioning persons with autism to respect the feelings and needs of other persons as sometimes overruling the duty of truthfulness. We suggest this may even entail 'morally educating' children and adolescents with autism to become socially skilled empathic 'liars'.
C1 [Jaarsma, Pier; Welin, Stellan] Linkoping Univ, IMH, Div Hlth & Soc, Linkoping, Sweden.
[Gelhaus, Petra] Univ Munster, Inst Eth Hist & Philosophy Med, Munster, Germany.
RP Jaarsma, P (reprint author), Linkoping Univ, IMH, Div Hlth & Soc, Linkoping, Sweden.
EM pier.jaarsma@liu.se; gelhaus@uni-muenster.de; stellan.welin@liu.se
CR Barnbaum D.R., 2008, ETHICS AUTISM THEM B
Baron-Cohen S, 2008, Q J EXP PSYCHOL, V61, P64, DOI 10.1080/17470210701508749
Baron-Cohen S., 1999, PHILOS EXPLORATIONS, V2, P175, DOI 10.1080/10001999098538705
Birch J., 2003, CONGRATULATIONS ITS
DePaulo BM, 1996, J PERS SOC PSYCHOL, V70, P979, DOI 10.1037/0022-3514.70.5.979
Fallis Don, 2010, PHILOS IMPRINT, V10, P1
Fitzgerald M., 2005, GENESIS ARTISTIC CRE
Fitzgerald M., 2010, PSYCHIAT THEOR APPL
Fleisher Marc, 2003, MAKING SENSE UNFEASI
Gavrilets S, 2006, P NATL ACAD SCI USA, V103, P16823, DOI 10.1073/pnas.0601428103
Grandin Temple, 2006, THINKING PICTURES MY, Vrev
Greenspan P., 2004, THINKING FEELING CON
Guseinov A.A., 2010, RUSSIAN STUDIES PHIL, V48, P26
Kant I., 2002, GROUNDWORK METAPHYSI
Kennett J, 2002, PHILOS QUART, V52, P340, DOI 10.1111/1467-9213.00272
Kleinman J, 2001, J AUTISM DEV DISORD, V31, P29, DOI 10.1023/A:1005657512379
Korsgaard Christine, 1996, CREATING KINGDOM END
Kuhn T.S, 1977, ESSENTIAL TENSION SE
Lawson W., 2009, THESIS DEAKIN U
Mor C., 2007, BLESSING CURSE AUTIS
Nordenfelt L., 1987, NATURE HLTH
Nussbaum M., 2004, THINKING FEELING CON
Nyberg D., 1993, VARNISHED TRUTH TRUT
Purkis J., 2006, FINDING DIFFERENT KI
Schneider E, 1999, DISCOVERING MY AUTIS
Shapiro T., 2006, ETHICS, V117, P32
Shoemaker D, 2007, ETHICS, V118, P70, DOI 10.1086/521280
Slote M., 2007, ETHICS CARE EMPATHY
Smith A, 2006, PSYCHOL REC, V56, P3
Smith A, 2009, PSYCHOL REC, V59, P489
Verkerk M A, 2001, Med Health Care Philos, V4, P289, DOI 10.1023/A:1012048907443
Wing L, 1997, LANCET, V350, P1761, DOI 10.1016/S0140-6736(97)09218-0
NR 32
TC 1
Z9 1
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 1386-7423
J9 MED HEALTH CARE PHIL
JI Med. Health Care Philos.
PD AUG
PY 2012
VL 15
IS 3
BP 271
EP 277
DI 10.1007/s11019-011-9363-7
PG 7
WC Ethics; History & Philosophy Of Science
SC Social Sciences - Other Topics; History & Philosophy of Science
GA 986ZL
UT WOS:000307386100003
PM 22065242
ER
PT J
AU Kim, KY
Jung, YW
Sullivan, GJ
Chung, L
Park, IH
AF Kim, Kun-Yong
Jung, Yong Wook
Sullivan, Gareth J.
Chung, Leeyup
Park, In-Hyun
TI Cellular reprogramming: a novel tool for investigating autism spectrum
disorders
SO TRENDS IN MOLECULAR MEDICINE
LA English
DT Review
ID PLURIPOTENT STEM-CELLS; FRAGILE-X-SYNDROME; CHILDHOOD-ONSET
SCHIZOPHRENIA; COPY NUMBER VARIATION; HUMAN SOMATIC-CELLS;
RETT-SYNDROME; IPS CELLS; DIRECT CONVERSION; DEFINED FACTORS;
PARKINSONS-DISEASE
AB Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by impairment in reciprocal social interaction and communication, as well as the manifestation of stereotyped behaviors. Despite much effort, ASDs are not yet fully understood. Advanced genetics and genomics technologies have recently identified novel ASD genes, and approaches using genetically engineered murine models or postmortem human brain have facilitated understanding ASD. Reprogramming somatic cells into induced pluripotent stem cells (iPSCs) provides unprecedented opportunities in generating human disease models. Here, we present an overview of applying iPSCs in developing cellular models for understanding ASD. We also discuss future perspectives in the use of iPSCs as a source of cell therapy and as a screening platform for identifying small molecules with efficacy for alleviating ASD.
C1 [Kim, Kun-Yong; Jung, Yong Wook; Park, In-Hyun] Yale Univ, Sch Med, Dept Genet, Yale Stem Cell Ctr, New Haven, CT 06520 USA.
[Jung, Yong Wook] CHA Univ, CHA Gangnam Med Ctr, Dept Obstet & Gynecol, Seoul, South Korea.
[Sullivan, Gareth J.] Univ Oslo, Inst Basic Med Sci, Fac Med, Stem Cell Epigenet Lab, Oslo, Norway.
[Sullivan, Gareth J.] Norwegian Ctr Stem Cell Res, N-0317 Oslo, Norway.
[Chung, Leeyup] Duke Univ, Med Ctr, Dept Pediat, Durham, NC 27710 USA.
RP Park, IH (reprint author), Yale Univ, Sch Med, Dept Genet, Yale Stem Cell Ctr, 10 Amistad,201B, New Haven, CT 06520 USA.
EM inhyun.park@yale.edu
FU Yale School of Medicine; Charles Hood Foundation; NIGMS [GM099130-01];
CHA University
FX This work was partly supported by Yale School of Medicine, Child Health
research Awards from Charles Hood Foundation and NIGMS GM099130-01 (to
I-H.P.). Y.W.J. is supported by a faculty research grant of the CHA
University.
CR Aasen T, 2008, NAT BIOTECHNOL, V26, P1276, DOI 10.1038/nbt.1503
Abrahams BS, 2008, NAT REV GENET, V9, P341, DOI 10.1038/nrg2346
Addington AM, 2011, MOL PSYCHIATR, V16, P238, DOI 10.1038/mp.2010.59
Amenduni M, 2011, EUR J HUM GENET, V19, P1246, DOI 10.1038/ejhg.2011.131
Ananiev G, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0025255
Anokye-Danso F, 2011, CELL STEM CELL, V8, P376, DOI 10.1016/j.stem.2011.03.001
Armstrong DD, 2005, J CHILD NEUROL, V20, P747, DOI 10.1177/08830738050200082401
BAILEY A, 1995, PSYCHOL MED, V25, P63
Ballas N, 2009, NAT NEUROSCI, V12, P311, DOI 10.1038/nn.2275
Bangash MA, 2011, CELL, V145, P758, DOI 10.1016/j.cell.2011.03.052
Bibikova M, 2003, SCIENCE, V300, P764, DOI 10.1126/science.1079512
Blenner S, 2011, BRIT MED J, V343, pd6238
Bock C, 2011, CELL, V144, P439, DOI 10.1016/j.cell.2010.12.032
Brennand KJ, 2011, NATURE, V473, P221, DOI 10.1038/nature09915
Brunet E, 2009, P NATL ACAD SCI USA, V106, P10620, DOI 10.1073/pnas.0902076106
BURD L, 1987, J AM ACAD CHILD PSY, V26, P700, DOI 10.1097/00004583-198709000-00014
Chamberlain SJ, 2010, P NATL ACAD SCI USA, V107, P17668, DOI 10.1073/pnas.1004487107
Chambers SM, 2009, NAT BIOTECHNOL, V27, P275, DOI 10.1038/nbt.1529
Chen RZ, 2001, NAT GENET, V27, P327, DOI 10.1038/85906
Cheung A.Y., 2011, HUM MOL GENET, V3, P3
Chiang CH, 2011, MOL PSYCHIATR, V16, P358, DOI 10.1038/mp.2011.13
Christian M, 2010, GENETICS, V186, P757, DOI 10.1534/genetics.110.120717
Cooper GM, 2011, NAT GENET, V43, P838, DOI 10.1038/ng.909
Deng J, 2009, NAT BIOTECHNOL, V27, P353, DOI 10.1038/nbt.1530
Derecki NC, 2012, NATURE, V484, P105, DOI 10.1038/nature10907
Ebert AD, 2009, NATURE, V457, P277, DOI 10.1038/nature07677
Eiges R, 2007, CELL STEM CELL, V1, P568, DOI 10.1016/j.stem.2007.09.001
Eiraku M, 2008, CELL STEM CELL, V3, P519, DOI 10.1016/j.stem.2008.09.002
EVANS MJ, 1981, NATURE, V292, P154, DOI 10.1038/292154a0
Falk A, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0029597
Farra N, 2012, MOL PSYCHIAT
FENG Y, 1995, SCIENCE, V268, P731, DOI 10.1126/science.7732383
Folstein SE, 2001, NAT REV GENET, V2, P943, DOI 10.1038/35103559
Haase A, 2009, CELL STEM CELL, V5, P434, DOI 10.1016/j.stem.2009.08.021
Han DW, 2012, CELL STEM CELL, V10, P465, DOI 10.1016/j.stem.2012.02.021
Hansen DV, 2011, NEURON, V70, P645, DOI 10.1016/j.neuron.2011.05.006
Hockemeyer D, 2011, NAT BIOTECHNOL, V29, P731, DOI 10.1038/nbt.1927
Hotta A, 2009, NAT METHODS, V6, P370, DOI [10.1038/nmeth.1325, 10.1038/NMETH.1325]
Hu BY, 2010, P NATL ACAD SCI USA, V107, P4335, DOI 10.1073/pnas.0910012107
Idol JR, 2008, J AUTISM DEV DISORD, V38, P668, DOI 10.1007/s10803-007-0435-8
Jamain S, 2008, P NATL ACAD SCI USA, V105, P1710, DOI 10.1073/pnas.0711555105
Jamain S, 2003, NAT GENET, V34, P27, DOI 10.1038/ng1136
Just MA, 2007, CEREB CORTEX, V17, P951, DOI 10.1093/cercor/bhl006
Kaji K, 2009, NATURE, V458, P771, DOI 10.1038/nature07864
Keirstead HS, 2005, J NEUROSCI, V25, P4694, DOI 10.1523/JNEUROSCI.0311-05.2005
Kim D, 2009, CELL STEM CELL, V4, P472, DOI 10.1016/j.stem.2009.05.005
Kim K, 2010, NATURE, V467, P285, DOI 10.1038/nature09342
Kim KY, 2011, P NATL ACAD SCI USA, V108, P14169, DOI 10.1073/pnas.1018979108
Klauck SM, 2006, MOL PSYCHIATR, V11, P1073, DOI 10.1038/sj.mp.4001883
Kogan MD, 2009, PEDIATRICS, V124, P1395, DOI 10.1542/peds.2009-1522
Laflamme MA, 2007, NAT BIOTECHNOL, V25, P1015, DOI 10.1038/nbt1327
Lamba DA, 2009, CELL STEM CELL, V4, P73, DOI 10.1016/j.stem.2008.10.015
Lengner CJ, 2010, CELL, V141, P872, DOI 10.1016/j.cell.2010.04.010
Li XJ, 2009, DEVELOPMENT, V136, P4055, DOI 10.1242/dev.036624
Liu H, 2010, HEPATOLOGY, V51, P1810, DOI 10.1002/hep.23626
Loh YH, 2009, BLOOD, V113, P5476, DOI 10.1182/blood-2009-02-204800
Lujan E, 2012, P NATL ACAD SCI USA, V109, P2527, DOI 10.1073/pnas.1121003109
Magdaleno S, 2002, NEURON, V33, P573, DOI 10.1016/S0896-6273(02)00582-2
Marchetto MCN, 2010, CELL, V143, P527, DOI 10.1016/j.cell.2010.10.016
MARTIN GR, 1981, P NATL ACAD SCI-BIOL, V78, P7634, DOI 10.1073/pnas.78.12.7634
Martins-Taylor K, 2011, NAT BIOTECHNOL, V29, P488, DOI 10.1038/nbt.1890
Mekhoubad S, 2012, CELL STEM CELL, V10, P595, DOI 10.1016/j.stem.2012.02.014
Michalon A, 2012, NEURON, V74, P49, DOI 10.1016/j.neuron.2012.03.009
Miller JC, 2011, NAT BIOTECHNOL, V29, P143, DOI 10.1038/nbt.1755
Moy SS, 2008, MOL PSYCHIATR, V13, P4, DOI 10.1038/sj.mp.4002082
Mussolino C, 2011, NUCLEIC ACIDS RES, V39, P9283, DOI 10.1093/nar/gkr597
Pang ZPP, 2011, NATURE, V476, P220, DOI 10.1038/nature10202
Park IH, 2008, CELL, V134, P877, DOI 10.1016/j.cell.2008.07.041
Pasca SP, 2011, NAT MED, V17, P1657, DOI 10.1038/nm.2576
Pedrosa E, 2011, J NEUROGENET, V25, P88, DOI 10.3109/01677063.2011.597908
Penagarikano O, 2011, CELL, V147, P235, DOI 10.1016/j.cell.2011.08.040
Perez SVD, 2012, HUM MOL GENET, V21, P751, DOI 10.1093/hmg/ddr506
Polo JM, 2010, NAT BIOTECHNOL, V28, P848, DOI 10.1038/nbt.1667
Pomp O, 2011, CELL STEM CELL, V9, P156, DOI 10.1016/j.stem.2011.06.004
Rakic P, 2009, NAT REV NEUROSCI, V10, P724, DOI 10.1038/nrn2719
Rapoport J, 2009, J AM ACAD CHILD PSY, V48, P10, DOI 10.1097/CHI.0b013e31818b1c63
Raya A, 2009, NATURE, V460, P53, DOI 10.1038/nature08129
Rhee YH, 2011, J CLIN INVEST, V121, P2326, DOI 10.1172/JCI45794
Robertson HR, 2011, J CHILD PSYCHOL PSYC, V52, P442, DOI 10.1111/j.1469-7610.2011.02380.x
Sheridan SD, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0026203
Shi YC, 2012, NAT NEUROSCI, V15, P477, DOI 10.1038/nn.3041
Soldner F, 2009, CELL, V136, P964, DOI 10.1016/j.cell.2009.02.013
State MW, 2011, NAT NEUROSCI, V14, P1499, DOI 10.1038/nn.2924
STEFFENBURG S, 1989, J CHILD PSYCHOL PSYC, V30, P405, DOI 10.1111/j.1469-7610.1989.tb00254.x
Sullivan PF, 2003, ARCH GEN PSYCHIAT, V60, P1187, DOI 10.1001/archpsyc.60.12.1187
Sutcliffe James S., 1992, Human Molecular Genetics, V1, P397, DOI 10.1093/hmg/1.6.397
Swijnenburg RJ, 2008, P NATL ACAD SCI USA, V105, P12991, DOI 10.1073/pnas.0805802105
Sykes NH, 2009, EUR J HUM GENET, V17, P1347, DOI 10.1038/ejhg.2009.47
Szatmari P, 2007, NAT GENET, V39, P319, DOI 10.1038/ng1985
Taapken SM, 2011, NAT BIOTECHNOL, V29, P313, DOI 10.1038/nbt.1835
Takahashi K, 2007, CELL, V131, P861, DOI 10.1016/j.cell.2007.11.019
Takahashi K, 2006, CELL, V126, P663, DOI 10.1016/j.cell.2006.07.024
Tchieu J, 2010, CELL STEM CELL, V7, P329, DOI 10.1016/j.stem.2010.06.024
Thier M, 2012, CELL STEM CELL, V10, P473, DOI 10.1016/j.stem.2012.03.003
Toro R, 2010, TRENDS GENET, V26, P363, DOI 10.1016/j.tig.2010.05.007
Urbach A, 2010, CELL STEM CELL, V6, P407, DOI 10.1016/j.stem.2010.04.005
Vierbuchen T, 2010, NATURE, V463, P1035, DOI 10.1038/nature08797
Voineagu I, 2011, NATURE, V474, P380, DOI 10.1038/nature10110
Weiss LA, 2009, NATURE, V461, P802, DOI 10.1038/nature08490
Wernig M, 2008, P NATL ACAD SCI USA, V105, P5856, DOI 10.1073/pnas.0801677105
Yang DL, 2008, STEM CELLS, V26, P55, DOI 10.1634/stemcells.2007-0494
Yang JY, 2010, J BIOL CHEM, V285, P40303, DOI 10.1074/jbc.M110.183392
Yazawa M, 2011, NATURE, V471, P230, DOI 10.1038/nature09855
Ye L, 2009, P NATL ACAD SCI USA, V106, P9826, DOI 10.1073/pnas.0904689106
NR 104
TC 6
Z9 6
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1471-4914
J9 TRENDS MOL MED
JI Trends Mol. Med
PD AUG
PY 2012
VL 18
IS 8
BP 463
EP 471
DI 10.1016/j.molmed.2012.06.002
PG 9
WC Biochemistry & Molecular Biology; Cell Biology; Medicine, Research &
Experimental
SC Biochemistry & Molecular Biology; Cell Biology; Research & Experimental
Medicine
GA 994DY
UT WOS:000307912300005
PM 22771169
ER
PT J
AU Singh, RK
Cooper, TA
AF Singh, Ravi K.
Cooper, Thomas A.
TI Pre-mRNA splicing in disease and therapeutics
SO TRENDS IN MOLECULAR MEDICINE
LA English
DT Review
DE alternative splicing; cis mutations; trans splicing factors;
spliceosome; splicing related human diseases; antisense oligonucleotide
therapy
ID MYOTONIC-DYSTROPHY TYPE-1; DUCHENNE MUSCULAR-DYSTROPHY; TRIPLET REPEAT
RNA; DEVELOPMENTAL DISORDER; HEXANUCLEOTIDE REPEAT; CHLORIDE CHANNEL;
PYRUVATE-KINASE; TRANSGENIC MICE; SKELETAL-MUSCLE; CANDIDATE-GENE
AB In metazoans, alternative splicing of genes is essential for regulating gene expression and contributing to functional complexity. Computational predictions, comparative genomics, and transcriptome profiling of normal and diseased tissues indicate that an unexpectedly high fraction of diseases are caused by mutations that alter splicing. Mutations in cis elements cause missplicing of genes that alter gene function and contribute to disease pathology. Mutations of core spliceosomal factors are associated with hematolymphoid neoplasias, retinitis pigmentosa, and microcephalic osteodysplastic primordial dwarfism type 1 (MOPD1). Mutations in the trans regulatory factors that control alternative splicing are associated with autism spectrum disorder, amyotrophic lateral sclerosis (ALS), and various cancers. In addition to discussing the disorders caused by these mutations, this review summarizes therapeutic approaches that have emerged to correct splicing of individual genes or target the splicing machinery.
C1 [Singh, Ravi K.; Cooper, Thomas A.] Baylor Coll Med, Dept Pathol & Immunol, Houston, TX 77030 USA.
[Cooper, Thomas A.] Baylor Coll Med, Dept Mol & Cellular Biol, Houston, TX 77030 USA.
[Cooper, Thomas A.] Baylor Coll Med, Dept Mol Physiol & Biophys, Houston, TX 77030 USA.
RP Cooper, TA (reprint author), Baylor Coll Med, Dept Pathol & Immunol, Houston, TX 77030 USA.
EM tcooper@bcm.edu
CR Aartsma-Rus A, 2009, HUM MUTAT, V30, P293, DOI 10.1002/humu.20918
Ahn EY, 2008, P NATL ACAD SCI USA, V105, P17103, DOI 10.1073/pnas.0802696105
Albert BJ, 2009, MOL CANCER THER, V8, P2308, DOI 10.1158/1535-7163.MCT-09-0051
Arambula JF, 2009, P NATL ACAD SCI USA, V106, P16068, DOI 10.1073/pnas.0901824106
Auld D., 2010, PROBE REPROTS NIH MO
Baralle D, 2005, J MED GENET, V42, P737, DOI 10.1136/jmg.2004.029538
Barnby G, 2005, AM J HUM GENET, V76, P950, DOI 10.1086/430454
Baylin SB, 2011, NAT REV CANCER, V11, P726, DOI 10.1038/nrc3130
Bennett CF, 2010, ANNU REV PHARMACOL, V50, P259, DOI 10.1146/annurev.pharmtox.010909.105654
BERGET SM, 1995, J BIOL CHEM, V270, P2411
Buj-Bello A, 2002, HUM MOL GENET, V11, P2297, DOI 10.1093/hmg/11.19.2297
Buratti E, 2011, NUCLEIC ACIDS RES, V39, pD86, DOI 10.1093/nar/gkq887
Caldenhoven E, 1996, J BIOL CHEM, V271, P13221
Chandler DS, 2006, CANCER RES, V66, P9502, DOI 10.1158/0008-5472.CAN-05-4271
Chang JG, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0018643
Charlet-B N, 2002, MOL CELL, V10, P45, DOI 10.1016/S1097-2765(02)00572-5
Christofk HR, 2008, NATURE, V452, P230, DOI 10.1038/nature06734
Cirak S, 2011, LANCET, V378, P595, DOI 10.1016/S0140-6736(11)60756-3
Cooper TA, 2009, CELL, V136, P777, DOI 10.1016/j.cell.2009.02.011
Corrionero A, 2011, GENE DEV, V25, P445, DOI 10.1101/gad.2014311
Couthouis J, 2011, P NATL ACAD SCI USA, V108, P20881, DOI 10.1073/pnas.1109434108
Da Cruz S, 2011, CURR OPIN NEUROBIOL, V21, P904, DOI 10.1016/j.conb.2011.05.029
Dansithong W, 2005, J BIOL CHEM, V280, P5773, DOI 10.1074/jbc.M410781200
Daughters RS, 2009, PLOS GENET, V5, DOI 10.1371/journal.pgen.1000600
David CJ, 2010, GENE DEV, V24, P2343, DOI 10.1101/gad.1973010
David CJ, 2010, NATURE, V463, P364, DOI 10.1038/nature08697
DeJesus-Hernandez M, 2011, NEURON, V72, P245, DOI 10.1016/j.neuron.2011.09.011
Dhir A, 2010, FEBS J, V277, P841, DOI 10.1111/j.1742-4658.2009.07520.x
Dutertre M, 2010, RNA BIOL, V7, P403
Edery P, 2011, SCIENCE, V332, P240, DOI 10.1126/science.1202205
Ek CJ, 2003, J COMP NEUROL, V460, P451, DOI 10.1002/cne.10661
Ezponda T, 2010, CLIN CANCER RES, V16, P4113, DOI 10.1158/1078-0432.CCR-10-0076
Faustino NA, 2003, GENE DEV, V17, P419, DOI 10.1101/gad.1048803
Foff EP, 2011, MUSCLE NERVE, V44, P160, DOI 10.1002/mus.22090
Fugier C, 2011, NAT MED, V17, P720, DOI 10.1038/nm.2374
Gabut M, 2008, CELL, V133, P192, DOI 10.1016/j.cell.2008.03.010
Garcia-Blanco MA, 2006, PROG MOLEC, V44, P47
Garcia-Lopez A, 2011, P NATL ACAD SCI USA, V108, P11866, DOI 10.1073/pnas.1018213108
Gehman LT, 2011, NAT GENET, V43, P706, DOI 10.1038/ng.841
Ghigna C, 2005, MOL CELL, V20, P881, DOI 10.1016/j.molcel.2005.10.026
Gitler AD, 2011, PRION, V5, P179, DOI 10.4161/pri.5.3.17230
Goemans NM, 2011, NEW ENGL J MED, V364, P1513, DOI 10.1056/NEJMoa1011367
Graubert TA, 2011, NAT GENET, V44, P53
Green RE., 2003, BIOINFORMATICS S1, V19, P1118
Hammond SM, 2011, TRENDS GENET, V27, P196, DOI 10.1016/j.tig.2011.02.004
Hanahan D, 2011, CELL, V144, P646, DOI 10.1016/j.cell.2011.02.013
Hasegawa M, 2011, ACS CHEM BIOL, V6, P229, DOI 10.1021/cb100248e
He HL, 2011, SCIENCE, V332, P238, DOI 10.1126/science.1200587
Hirabayashi S, 2012, BLOOD, V119, pE96, DOI 10.1182/blood-2011-12-395087
Ho TH, 2005, HUM MOL GENET, V14, P1539, DOI 10.1093/hmg/ddi162
Holmes SE, 1999, NAT GENET, V23, P391
Hua YM, 2010, GENE DEV, V24, P1634, DOI 10.1101/gad.1941310
Hua YM, 2011, NATURE, V478, P123, DOI 10.1038/nature10485
Iwahashi CK, 2006, BRAIN, V129, P256, DOI 10.1093/brain/awh650
Jiang H, 2004, HUM MOL GENET, V13, P3079, DOI 10.1093/hmg/ddh327
Kaida D, 2007, NAT CHEM BIOL, V3, P576, DOI 10.1038/nchembio.2007.18
Kalsotra A, 2011, NAT REV GENET, V12, P715, DOI 10.1038/nrg3052
Karni R, 2007, NAT STRUCT MOL BIOL, V14, P185, DOI 10.1038/nmb1209
Kielkopf CL, 2004, GENE DEV, V18, P1513, DOI 10.1101/gad.1206204
KIM S, 2011, N KOREAN REV, V7, P3
Kimura T, 2005, HUM MOL GENET, V14, P2189, DOI 10.1093/hmg/ddi223
Kotake Y, 2007, NAT CHEM BIOL, V3, P570, DOI 10.1038/nchembio.2007.16
Krawczak M, 2007, HUM MUTAT, V28, P150, DOI 10.1002/humu.20400
Krzyzosiak WJ, 2012, NUCLEIC ACIDS RES, V40, P11, DOI 10.1093/nar/gkr729
Kuyumcu-Martinez M.N., 2007, MOL CELL, V28, P68
Lagier-Tourenne C, 2010, HUM MOL GENET, V19, pR46, DOI 10.1093/hmg/ddq137
Lee JE, 2012, P NATL ACAD SCI USA, V109, P4221, DOI 10.1073/pnas.1117019109
LeFave CV, 2011, EMBO J, V30, P4084, DOI 10.1038/emboj.2011.259
Lim KH, 2011, P NATL ACAD SCI USA, V108, P11093, DOI 10.1073/pnas.1101135108
Lopez-Bigas N, 2005, FEBS LETT, V579, P1900, DOI 10.1016/j.febslet.2005.02.047
Lopez-Mejia IC, 2011, HUM MOL GENET, V20, P4540, DOI 10.1093/hmg/ddr385
Luco RF, 2011, CURR OPIN GENET DEV, V21, P366, DOI 10.1016/j.gde.2011.03.004
Makishima H, 2012, BLOOD, V119, P3203, DOI 10.1182/blood-2011-12-399774
Mankodi A, 2002, MOL CELL, V10, P35, DOI 10.1016/S1097-2765(02)00563-4
Martin CL, 2007, AM J MED GENET B, V144B, P869, DOI 10.1002/ajmg.b.30530
Mizui Y, 2004, J ANTIBIOT, V57, P188
Moore MJ, 2010, CELL, V142, P625, DOI 10.1016/j.cell.2010.07.019
Mulders SAM, 2009, P NATL ACAD SCI USA, V106, P13915, DOI 10.1073/pnas.0905780106
Nakajima H, 1996, J ANTIBIOT, V49, P1204
Ngo JCK, 2005, MOL CELL, V20, P77, DOI 10.1016/j.molcel.2005.08.025
Nilsen TW, 2010, NATURE, V463, P457, DOI 10.1038/nature08909
Nottrott S, 2002, EMBO J, V21, P5527, DOI 10.1093/emboj/cdf544
O'Brien K, 2008, J BIOL CHEM, V283, P33147, DOI 10.1074/jbc.M805556200
Osorio FG, 2011, SCI TRANSL MED, V3, DOI 10.1126/scitranslmed.3002847
Papaemmanuil E, 2011, NEW ENGL J MED, V365, P1384, DOI 10.1056/NEJMoa1103283
Passini MA, 2011, SCI TRANSL MED, V3, DOI 10.1126/scitranslmed.3001777
Patel AA, 2003, NAT REV MOL CELL BIO, V4, P960, DOI 10.1038/nrm1259
Perez B, 2010, J INHERIT METAB DIS, V33, P397, DOI 10.1007/s10545-010-9135-1
Philips AV, 1998, SCIENCE, V280, P737, DOI 10.1126/science.280.5364.737
Polymenidou M, 2011, NAT NEUROSCI, V14, P459, DOI 10.1038/nn.2779
Poulos MG, 2011, CSH PERSPECT BIOL, V3, DOI 10.1101/cshperspect.a000778
Prasad J, 2003, MOL CELL BIOL, V23, P4139, DOI 10.1128/MCB.23.12.4139-4149.2003
Pushechnikov A, 2009, J AM CHEM SOC, V131, P9767, DOI 10.1021/ja9020149
Quesada V, 2012, NAT GENET, V44, P47, DOI 10.1038/ng.1032
Ranum LPW, 2006, ANNU REV NEUROSCI, V29, P259, DOI 10.1146/annurev.neuro.29.051605.113014
Renton AE, 2011, NEURON, V72, P257, DOI 10.1016/j.neuron.2011.09.010
Savkur RS, 2004, AM J HUM GENET, V74, P1309, DOI 10.1086/421528
Shen HH, 2010, GENE DEV, V24, P2389, DOI 10.1101/gad.1974810
Shukla S, 2011, NATURE, V479, P74, DOI 10.1038/nature10442
Stamm S, 2008, J BIOL CHEM, V283, P1223, DOI 10.1074/jbc.R700034200
Sterne-Weiler T, 2011, GENOME RES, V21, P1563, DOI 10.1101/gr.118638.110
Taniguchi-Ikeda M, 2011, NATURE, V478, P127, DOI 10.1038/nature10456
Timchenko NA, 2001, J BIOL CHEM, V276, P7820, DOI 10.1074/jbc.M005960200
Tollervey JR, 2011, NAT NEUROSCI, V14, P452, DOI 10.1038/nn.2778
Vander Heiden Matthew G, 2009, Science, V324, P1029, DOI 10.1126/science.1160809
Venables JP, 2006, BIOESSAYS, V28, P378, DOI 10.1002/bies.20390
Voineagu I, 2011, NATURE, V474, P380, DOI 10.1038/nature10110
Vorechovsky I, 2010, HUM GENET, V127, P135, DOI 10.1007/s00439-009-0752-4
Wahl MC, 2009, CELL, V136, P701, DOI 10.1016/j.cell.2009.02.009
Wang GS, 2007, NAT REV GENET, V8, P749, DOI 10.1038/nrg2164
Wang LL, 2011, NEW ENGL J MED, V365, P2497, DOI 10.1056/NEJMoa1109016
Warf MB, 2009, P NATL ACAD SCI USA, V106, P18551, DOI 10.1073/pnas.0903234106
Wheeler TM, 2009, SCIENCE, V325, P336, DOI 10.1126/science.1173110
White M, 2012, J NEUROSCI RES, V90, P706, DOI 10.1002/jnr.22786
Will CL, 2005, BIOL CHEM, V386, P713, DOI 10.1515/BC.2005.084
Wood MJA, 2010, BRAIN, V133, P957, DOI 10.1093/brain/awq002
Xu GT, 2009, MOL MED REP, V2, P819, DOI 10.3892/mmr_00000178
Yoon SO, 2006, MOL CANCER THER, V5, P2666, DOI 10.1158/1535-7163.MCT-06-0321
Yoshida K, 2011, NATURE, V478, P64, DOI 10.1038/nature10496
Zammarchi F, 2011, P NATL ACAD SCI USA, V108, P17779, DOI 10.1073/pnas.1108482108
Zhang Y, 2011, GENE THER, V18, P1139, DOI 10.1038/gt.2011.170
NR 121
TC 82
Z9 85
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1471-4914
J9 TRENDS MOL MED
JI Trends Mol. Med
PD AUG
PY 2012
VL 18
IS 8
BP 472
EP 482
DI 10.1016/j.molmed.2012.06.006
PG 11
WC Biochemistry & Molecular Biology; Cell Biology; Medicine, Research &
Experimental
SC Biochemistry & Molecular Biology; Cell Biology; Research & Experimental
Medicine
GA 994DY
UT WOS:000307912300006
PM 22819011
ER
PT J
AU Penagarikano, O
Geschwind, DH
AF Penagarikano, Olga
Geschwind, Daniel H.
TI What does CNTNAP2 reveal about autism spectrum disorder? (vol 18, pg
156, 2012)
SO TRENDS IN MOLECULAR MEDICINE
LA English
DT Correction
C1 [Penagarikano, Olga; Geschwind, Daniel H.] Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurol, Program Neurogenet, Los Angeles, CA 90095 USA.
[Penagarikano, Olga; Geschwind, Daniel H.] Univ Calif Los Angeles, Semel Inst Neurosci & Human Behav, Ctr Autism Res & Treatment, Los Angeles, CA 90095 USA.
[Geschwind, Daniel H.] Univ Calif Los Angeles, Semel Inst Neurosci & Human Behav, Ctr Neurobehav Genet, Los Angeles, CA 90095 USA.
RP Penagarikano, O (reprint author), Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurol, Program Neurogenet, Los Angeles, CA 90095 USA.
CR O'Roak BJ, 2012, NAT GENET, V44, P471
O'Roak BJ, 2011, NAT GENET, V43, P585, DOI 10.1038/ng.835
Penagarikano O, 2012, TRENDS MOL MED, V18, P156, DOI 10.1016/j.molmed.2012.01.003
NR 3
TC 0
Z9 0
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1471-4914
J9 TRENDS MOL MED
JI Trends Mol. Med
PD AUG
PY 2012
VL 18
IS 8
BP 502
EP 502
PG 1
WC Biochemistry & Molecular Biology; Cell Biology; Medicine, Research &
Experimental
SC Biochemistry & Molecular Biology; Cell Biology; Research & Experimental
Medicine
GA 994DY
UT WOS:000307912300009
ER
PT J
AU Marx, G
Gilon, C
AF Marx, Gerard
Gilon, Chaim
TI The Molecular Basis of Memory
SO ACS CHEMICAL NEUROSCIENCE
LA English
DT Editorial Material
DE Memory; information; ionic chip; neuron; extracellular matrix; trace
metal
ID BRAIN EXTRACELLULAR-MATRIX; CHONDROITIN SULFATE PROTEOGLYCAN;
MAGNETIC-RESONANCE SPECTROSCOPY; NEUTRON-ACTIVATION ANALYSIS;
CENTRAL-NERVOUS-SYSTEM; TENASCIN-R; SYNAPTIC PLASTICITY;
HYALURONIC-ACID; DEFICIENT MICE; ION CHANNELS
AB We propose a tripartite biochemical mechanism for memory. Three physiologic components are involved, namely, the neuron (individual and circuit), the surrounding neural extracellular matrix, and the various trace metals distributed within the matrix. The binding of a metal cation affects a corresponding nanostructure (shrinking twisting, expansion) and dielectric sensibility of the chelating node (address) within the matrix lattice, sensed by the neuron. The neural extracellular matrix serves as an electro-elastic lattice, wherein neurons manipulate multiple trace metals (n > 10) to encode, store, and decode coginive information. The proposed mechanism explains brains low energy requirements and high rates of storage capacity described in multiples of Avogadro number (N-A = 6 x 10(23)). Supportive evidence correlates memory loss to trace metal toxicity or deficiency, or breakdown in the delivery/transport of metals to the matrix, or its degradation. Inherited diseases revolving around dysfunctional trace metal metabolism and memory dysfunction, include Alzheimer's disease (Al, Zn, Fe), Wilson's disease (Cu), thalassemia (Fe), and autism (metallothionein). The tripartite mechanism points to the electro-elastic interactions of neurons with trace metals distributed within the neural extracellular matrix, as the molecular underpinning of "synaptic plasticity" affecting short-term memory, long-term memory, and forgetting.
C1 [Marx, Gerard] MX Biotech Ltd, Jerusalem, Israel.
[Gilon, Chaim] Hebrew Univ Jerusalem, Inst Chem, IL-91904 Jerusalem, Israel.
RP Marx, G (reprint author), MX Biotech Ltd, Jerusalem, Israel.
EM gerardmarx@gmail.com; chaimgilon@gmail.com
CR Aho A. V., 2011, UB S ASS COMP MACH N
Alexe-Ionescu AL, 2012, J APPL PHYS, V111, DOI 10.1063/1.3675522
Al-Saleh I, 2001, BIOL TRACE ELEM RES, V79, P197, DOI 10.1385/BTER:79:3:197
Anastassiou C. A., 2011, NAT NEUROSCI, VXX, P1
Anastassiou CA, 2010, J NEUROSCI, V30, P1925, DOI 10.1523/JNEUROSCI.3635-09.2010
Arenz A, 2008, SCIENCE, V321, P977, DOI 10.1126/science.1158391
Aschner M, 1996, FASEB J, V10, P1129
BALT S, 1983, J INORG BIOCHEM, V19, P213, DOI 10.1016/0162-0134(83)85026-0
Balter M, 2007, SCIENCE, V315, P1208, DOI 10.1126/science.315.5816.1208
Barbucci R, 2000, J INORG BIOCHEM, V81, P229, DOI 10.1016/S0162-0134(00)00127-6
Barbucci R, 2005, BIOMACROMOLECULES, V6, P212, DOI 10.1021/bm049568g
Bear M. F., 2001, NEUROSCIENCE EXPLORI, P97
Becker JS, 2010, INT J MASS SPECTROM, V289, P65, DOI 10.1016/j.ijms.2009.10.011
Becker JS, 2005, ANAL CHEM, V77, P3208, DOI 10.1021/ac040184q
Benenson Y, 2009, MOL BIOSYST, V5, P675, DOI 10.1039/b902484k
Bibb JA, 2010, J NEUROSCI, V30, P14987, DOI 10.1523/JNEUROSCI.4419-10.2010
Binczak S, 2001, PHYSICA D, V148, P159, DOI 10.1016/S0167-2789(00)00173-1
Bogdanov K Iu, 1974, Biull Eksp Biol Med, V78, P48
Bokil H, 2001, J NEUROSCI, V21
Bonneh-Barkay D, 2009, BRAIN PATHOL, V19, P573, DOI 10.1111/j.1750-3639.2008.00195.x
Bukalo O, 2008, NEURON GLIA BIOL, V4, P165, DOI 10.1017/S1740925X09990366
Bukalo O, 2001, NEUROSCIENCE, V104, P359, DOI 10.1016/S0306-4522(01)00082-3
Burger K, 2001, CARBOHYD RES, V332, P197, DOI 10.1016/S0008-6215(01)00065-9
Casdorph R. H., 1994, M WALKER HLTH BOOK
Castillo GM, 1997, J NEUROCHEM, V69, P2452
Chang L.W, 1996, TOXICOLOGY METALS
Charoo Naseem A., 2010, Current Drug Delivery, V7, P125
Chen A., 2008, INT C COMP NETW TECH, P1
Chung RS, 2008, J NEUROCHEM, V104, P14, DOI 10.1111/j.1171-4159.2007.05026.x
Clark RW, 1998, J CHEM EDUC, V75, P1182
Cofer C. N ., 1976, S STRUCT HUM MEM
Cole TB, 2001, BRAIN RES, V891, P253, DOI 10.1016/S0006-8993(00)03220-0
Cole TB, 1999, P NATL ACAD SCI USA, V96, P1716, DOI 10.1073/pnas.96.4.1716
Cook ND, 2008, NEUROSCIENCE, V153, P556, DOI 10.1016/j.neuroscience.2008.02.042
Curtis JT, 2010, BEHAV BRAIN RES, V213, P42, DOI 10.1016/j.bbr.2010.04.028
D'Auria G, 2003, BIOPOLYMERS, V70, P260, DOI 10.1002/bip.10433
Day JM, 2004, J BIOL CHEM, V279, P12511, DOI 10.1074/jbc.M400242200
Debanne D, 2008, NAT PROTOC, V3, P1559, DOI 10.1038/nprot.2008.147
DeFelipe J, 2010, SCIENCE, V330, P1198, DOI 10.1126/science.1193378
Deitmer JW, 2010, BRAIN RES REV, V63, P113, DOI 10.1016/j.brainresrev.2009.10.006
DE STASIO G, 1992, NEUROREPORT, V3, P965
Dityatev A, 2010, TRENDS NEUROSCI, V33, P503, DOI 10.1016/j.tins.2010.08.003
Dityatev A, 2006, CELL TISSUE RES, V326, P647, DOI 10.1007/s00441-006-0217-1
Dityatev A, 2010, NAT REV NEUROSCI, V11, P735, DOI 10.1038/nrn2898
Dityatev A, 2003, NAT REV NEUROSCI, V4, P456, DOI 10.1038/nrn1115
Donati A, 2001, BIOPOLYMERS, V59, P434, DOI 10.1002/1097-0282(200111)59:6<434::AID-BIP1048>3.0.CO;2-4
Dudai Y., 2004, SEDIMENATRY ENV PROC, V333, P108
Dwyer F. P., 1964, CHELATING AGENTS MET
Elinder F, 2003, Q REV BIOPHYS, V36, P373, DOI 10.1017/S0033583504003932
Erickson JC, 1997, J NEUROSCI, V17, P1271
EVANS GW, 1973, SCIENCE, V181, P1175, DOI 10.1126/science.181.4105.1175
Fairhall L. T., 1963, IND TOXICOLOGY
Fernandes M, 2011, ACS APPL MATER INTER, V3, P2953, DOI 10.1021/am200391b
Fink E. B., 1976, TRACE ELEMENTS HUMAN, VII, P1
Fischer EH, 1998, P NATL ACAD SCI USA, V95, P3333, DOI 10.1073/pnas.95.7.3333
Fischknecht R., 2008, NEURON GLIA BIOL, V4, P249
Fitsanakis VA, 2008, TOXICOL SCI, V103, P116, DOI 10.1093/toxsci/kfn019
FOX JM, 1974, PFLUG ARCH EUR J PHY, V351, P271, DOI 10.1007/BF00586923
Freitag S, 2003, BEHAV BRAIN RES, V145, P189, DOI 10.1016/S0166-4328(03)00109-8
Frey S, 2008, PROG BRAIN RES, V169, P117, DOI 10.1016/S0079-6123(07)00007-6
Friberg L., 2007, HDB TOXICOLOGY METAL
Fries P, 2009, ANNU REV NEUROSCI, V32, P209, DOI 10.1146/annurev.neuro.051508.135603
FRITZ LC, 1981, NATURE, V291, P190, DOI 10.1038/291190a0
Gallistel C. R., 2009, MEMORY COMPUTATIONAL
Gelbard-Sagiv H, 2008, SCIENCE, V322, P96, DOI 10.1126/science.1164685
GEVINS AS, 1985, PSYCHOPHYSIOLOGY, V22, P32, DOI 10.1111/j.1469-8986.1985.tb01557.x
GEVINS AS, 1987, SCIENCE, V235, P580, DOI 10.1126/science.3810158
GEVINS AS, 1983, SCIENCE, V220, P97, DOI 10.1126/science.6828886
Gilbert NE, 2007, IEEE J SOLID-ST CIRC, V42, P1383, DOI 10.1109/JSSC.2007.897172
Gogolla N, 2009, SCIENCE, V325, P1258, DOI 10.1126/science.1174146
Gonzalez E, 2011, SCIENCE, V334, P1377, DOI 10.1126/science.1212822
GONZALEZ RG, 1993, AM J NEURORADIOL, V14, P1027
Gratieri T, 2011, EXPERT OPIN DRUG DEL, V8, P645, DOI 10.1517/17425247.2011.566265
Green JE, 2007, NATURE, V445, P414, DOI 10.1038/nature05462
Grimnes S, 2008, BIOIMPEDANCE AND BIOELECTRICITY BASICS, 2ND EDITION, P1
GUHR G, 2009, C P IEEE ENG MED BIO, P729
Guiseppi-Elie A, 2010, BIOMATERIALS, V31, P2701, DOI 10.1016/j.biomaterials.2009.12.052
Guisun Z, 1991, J RADIOANAL NUCL CHE, V151, P327, DOI 10.1007/BF02035492
Gurevicius K, 2009, HIPPOCAMPUS, V19, P1232, DOI 10.1002/hipo.20585
HAMER DH, 1986, ANNU REV BIOCHEM, V55, P913, DOI 10.1146/annurev.biochem.55.1.913
HENKE G, 1971, Z NEUROL, V199, P283, DOI 10.1007/BF00316767
Hernandez PJ, 2008, NEUROBIOL LEARN MEM, V89, P293, DOI 10.1016/j.nlm.2007.09.010
Hlushkou D, 2008, LAB CHIP, V8, P1153, DOI 10.1039/b800549d
HOCK A, 1975, BRAIN, V98, P49, DOI 10.1093/brain/98.1.49
HOFFMAN S, 1987, P NATL ACAD SCI USA, V84, P2523, DOI 10.1073/pnas.84.8.2523
Hrabetova S, 2009, J PHYSIOL-LONDON, V587, P4029, DOI 10.1113/jphysiol.2009.170092
Hutchby JA, 2008, COMPUTER, V41, P28, DOI 10.1109/MC.2008.154
Hyden H., 1970, BIOL MEMORY
IWATA M, 1993, J NEUROSCI, V13, P195
IWATA M, 1993, J BIOL CHEM, V268, P15061
JEFFERYS JGR, 1995, PHYSIOL REV, V75, P689
JOHNSON FN, 1981, INT J NEUROSCI, V13, P199
Joynt R. J., 1975, CLIN NEUROSCIENCES, V2, P441
KAGI JHR, 1988, BIOCHEMISTRY-US, V27, P8509
Kampa BM, 2007, TRENDS NEUROSCI, V30, P456, DOI 10.1016/j.tins.2007.06.010
Kandel E., 2006, SEARCH MEMORY
KANDEL ER, 1982, SCIENCE, V218, P433, DOI 10.1126/science.6289442
Kappler J, 2002, BIOCHEM BIOPH RES CO, V294, P742, DOI 10.1016/S0006-291X(02)00520-X
Kasha P. C., 2008, DRUG DELIVERY FORMUL, V2, P41
Kawakami K, 2011, BIOL PHARM BULL, V34, P590
Keogh R, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0029221
Kern JK, 2007, J TOXICOL ENV HEAL A, V70, P715, DOI 10.1080/15287390601188060
KHULUSI SS, 1986, BRAIN RES, V363, P152, DOI 10.1016/0006-8993(86)90669-4
Kim SJ, 2005, SMART MATER STRUCT, V14, P511, DOI 10.1088/0964-1726/14/4/008
Kishida KT, 2009, CONTEMP CLIN NEUROSC, P1, DOI 10.1007/978-1-60327-342-8_1
Kjaer M, 2004, PHYSIOL REV, V84, P649, DOI 10.1152/physrev.00031.2003
Kleene R, 2004, NAT REV NEUROSCI, V5, P195, DOI 10.1038/nrn1349
Kmjevik K., 1986, NEWS PHYSIOL SCI, V1, P28
Kochlamazashvili G, 2010, NEURON, V67, P116, DOI 10.1016/j.neuron.2010.05.030
Koumura A, 2009, NEUROSCI LETT, V467, P11, DOI 10.1016/j.neulet.2009.09.051
Kreger ST, 2009, MATRIX BIOL, V28, P336, DOI 10.1016/j.matbio.2009.05.001
Lander C, 1998, J NEUROSCI, V18, P174
LANDON DN, 1971, J ANAT, V108, P419
Lee DH, 2010, SCIENCE, V330, P1807, DOI 10.1126/science.1197434
Lee MJ, 2011, NAT MATER, V10, P625, DOI [10.1038/nmat3070, 10.1038/NMAT3070]
Lee PF, 2010, NANOTECHNOLOGY, V21, DOI 10.1088/0957-4484/21/29/295706
Lesburgueres E, 2011, SCIENCE, V331, P924, DOI 10.1126/science.1196164
LEVIN E, 1971, AM J PHYSIOL, V221, P1319
Levin ED, 2006, PHYSIOL BEHAV, V87, P513, DOI 10.1016/j.physbeh.2005.11.014
Lieleg O, 2009, BIOPHYS J, V97, P1569, DOI 10.1016/j.bpj.2009.07.009
Lindner B, 2005, PHYS REV E, V72, DOI 10.1103/PhysRevE.72.021911
LLINAS RR, 1988, SCIENCE, V242, P1654, DOI 10.1126/science.3059497
Lundell A, 2004, STRUCTURE, V12, P1495, DOI 10.1016/j.str.2004.05.021
LYNCH G, 1984, SCIENCE, V224, P1057, DOI 10.1126/science.6144182
MARKESBERY WR, 1981, ANN NEUROL, V10, P511
Martel G, 2010, LEARN MEMORY, V17, P582, DOI 10.1101/lm.1962010
MATZEL LD, 1992, BEHAV NEUROSCI, V106, P954, DOI 10.1037/0735-7044.106.6.954
Mazzarello P, 2010, GOLGI BIOGRAPHY FOUN
McAuliffe JJ, 2008, BRAIN RES, V1190, P175, DOI 10.1016/j.brainres.2007.11.038
MCBAIN CJ, 1990, SCIENCE, V249, P674, DOI 10.1126/science.2382142
McGaugh JL, 2000, SCIENCE, V287, P248, DOI 10.1126/science.287.5451.248
Milev P, 1997, J BIOL CHEM, V272, P15501, DOI 10.1074/jbc.272.24.15501
Miller F. J., 2009, P NATL ACAD SCI USA, V106, P12174
Miller P, 2006, CHAOS, V16, DOI 10.1063/1.2208923
MISHKIN M, 1987, SCI AM, V256, P80
Mocatta D, 2011, SCIENCE, V332, P77, DOI 10.1126/science.1196321
Montag-Sallaz M, 2003, GENES BRAIN BEHAV, V2, P20, DOI 10.1034/j.1601-183X.2003.00003.x
Morellini F, 2010, CEREB CORTEX, V20, P2712, DOI 10.1093/cercor/bhq017
MOZHAEVA GN, 1973, TSITOLOGIYA+, V15, P1431
Muralidharan G, 2011, NANOSCALE, V3, P4575, DOI 10.1039/c1nr10884k
Murray L, 2011, TOXICOLOGY HDB
Nagy L, 1998, J INORG BIOCHEM, V72, P49, DOI 10.1016/S0162-0134(98)10061-2
NICHOLSON C, 1981, J PHYSIOL-LONDON, V321, P225
Nicholson C, 1998, TRENDS NEUROSCI, V21, P207, DOI 10.1016/S0166-2236(98)01261-2
NISHIMURA N, 1992, J HISTOCHEM CYTOCHEM, V40, P309
Norenberg U, 1996, INT J DEV NEUROSCI, V14, P217, DOI 10.1016/0736-5748(96)00009-3
Palmiter RD, 1996, P NATL ACAD SCI USA, V93, P14934, DOI 10.1073/pnas.93.25.14934
Palmiter RD, 1998, P NATL ACAD SCI USA, V95, P8428, DOI 10.1073/pnas.95.15.8428
Paradee N, 2012, J MATER SCI-MATER M, V23, P999, DOI 10.1007/s10856-012-4571-0
PASZTOR VM, 1982, SCIENCE, V215, P1635
Paz R, 2010, P NATL ACAD SCI USA, V107, P6046, DOI 10.1073/pnas.0910834107
Perea G, 2009, TRENDS NEUROSCI, V32, P421, DOI 10.1016/j.tins.2009.05.001
Piccinini G, 2004, SYNTHESE, V141, P175, DOI 10.1023/B:SYNT.0000043018.52445.3e
Piet R, 2004, P NATL ACAD SCI USA, V101, P2151, DOI 10.1073/pnas.0308408100
Pietrucha K, 2005, BIOPHYS CHEM, V118, P51, DOI 10.1016/j.bpc.2005.07.006
PLENGE P, 1994, BIOL PSYCHIAT, V36, P511, DOI 10.1016/0006-3223(94)90614-9
Popescu BFG, 2009, CEREBELLUM, V8, P74, DOI 10.1007/s12311-008-0091-3
Popescu BFG, 2011, CNS NEUROSCI THER, V17, P256, DOI 10.1111/j.1755-5949.2010.00149.x
Popke E.J., 2008, ACCESSSCIENCE
Pradel G, 2000, J NEUROBIOL, V43, P389, DOI 10.1002/1097-4695(20000615)43:4<389::AID-NEU7>3.0.CO;2-X
Priya L., 2011, BIOL TRACE ELEM RES, V142, P148
Probstmeier R, 2000, BRAIN RES, V863, P42, DOI 10.1016/S0006-8993(00)02075-8
Qin ZY, 2011, METALLOMICS, V3, P28, DOI 10.1039/c0mt00048e
Rasband MN, 2001, DEV BIOL, V236, P5, DOI 10.1006/dbio.2001.0326
Righetti Pier Giorgio, 2009, J Proteomics, V73, P181
Roberts R. B., 1969, Q REV BIOPHYS, P135
Roth W.T., 2000, PSYCHOPHARMACOLOGY 4
Routtenberg A, 2008, EUR J PHARMACOL, V585, P60, DOI 10.1016/j.ejphar.2008.02.047
Ruben M, 2004, ANGEW CHEM INT EDIT, V43, P3644, DOI 10.1002/anie.200300636
Russo AF, 2008, SWISS MED WKLY, V138, P70, DOI 10.1111/j.1399-3038.2005.00348.x
SACHS GS, 1995, BIOL PSYCHIAT, V38, P422, DOI 10.1016/0006-3223(94)00324-V
Sahu BS, 2011, NANOSCALE RES LETT, V6, DOI 10.1186/1556-276X-6-177
Santiago R. C., 1906, STUDIEN HIRNRINDE ME
Schmitt F. O., 1997, SEDIMENATRY ENV PROC, V193, P114
Schmitt R O, 1976, Science, V193, P114, DOI 10.1126/science.180598
Schumacher S, 2003, J NEUROCHEM, V87, P1213, DOI 10.1046/j.1471-4159.2003.02112.x
SHANNON CE, 1948, AT&T TECH J, V27, P623
Shelton JT, 2010, J EXP PSYCHOL LEARN, V36, P813, DOI 10.1037/a0019046
Sindreu C, 2011, P NATL ACAD SCI USA, V108, P3366, DOI 10.1073/pnas.1019166108
Singh VK, 2006, PEDIATR ALLERGY IMMU, V17, P291, DOI 10.1111/j.1399-3038.2005.00348.x
Smirnov AY, 2011, J PHYS-CONDENS MAT, V23, DOI 10.1088/0953-8984/23/23/234101
Spormns O., 2011, NETWORKS BRAIN
SQUIRE LR, 1986, SCIENCE, V232, P1612, DOI 10.1126/science.3086978
Srinivasan J, 1998, P NATL ACAD SCI USA, V95, P15753, DOI 10.1073/pnas.95.26.15753
Stolichnov I, 2011, NANOTECHNOLOGY, V22, DOI 10.1088/0957-4484/22/25/254004
SU MH, 1994, J PHARM SCI, V83, P12, DOI 10.1002/jps.2600830105
Sykova E, 2003, ISRAEL J CHEM, V43, P55, DOI 10.1560/11GA-DQD7-DC41-Q1U7
Sykova E, 2005, EUR J NEUROSCI, V22, P1873, DOI 10.1111/j.1460-9568.2005.04375.x
Sykova E, 2008, NEUROCHEM INT, V52, P5, DOI 10.1016/j.neuint.2007.04.007
Takeda A, 2001, J HEALTH SCI, V47, P520, DOI 10.1248/jhs.47.520
Talland G. A., 1969, PATHOLOGY MEMORY
Taub H. A., 1963, DESIGN COMPUTERS THE, VV
Taubenfeld SM, 1999, NAT NEUROSCI, V2, P309
Tesselaar E, 2011, MICROVASC RES, V81, P88, DOI 10.1016/j.mvr.2010.11.002
THOLEY G, 1988, NEUROCHEM RES, V13, P1163, DOI 10.1007/BF00971634
Tielrooij KJ, 2010, SCIENCE, V328, P1006, DOI 10.1126/science.1183512
Tinoco AD, 2007, J AM CHEM SOC, V129, P3444, DOI 10.1021/ja068149j
Tsien JZ, 2007, PROG BRAIN RES, V165, P105, DOI 10.1016/S0079-6123(06)65007-3
Turing A., 1950, MIND, V59, P433, DOI DOI 10.1093/MIND/LIX.236.433
Turing A., 1960, COMPUTATIONAL THEORY
TURNER RW, 1984, EXP BRAIN RES, V54, P567
Tzvetanov T, 2008, BIOL CYBERN, V98, P397, DOI 10.1007/s00422-008-0226-0
Valov I, 2011, NANOTECHNOLOGY, V22, DOI 10.1088/0957-4484/22/25/254003
Vargova L, 2008, PHYSIOL RES, V57, pS89
Vigetti D, 2008, CELL PHYSIOL BIOCHEM, V22, P137, DOI 10.1159/000149791
Vogels TP, 2011, SCIENCE, V334, P1569, DOI 10.1126/science.1211095
Vyvyan H. C., 1993, NEUROPROTOCOLS, V2, P113
Waldrop M. M., 1992, COMPLEXITY EMERGING
Waser R, 2007, NAT MATER, V6, P833, DOI 10.1038/nmat2023
Weber P, 1999, J NEUROSCI, V19, P4245
WEINER N., 1948, CYBERNETICS CONTROL
WEISS B, 1978, FED PROC, V37, P22
Weiss SA, 2010, FRONT NEURAL CIRCUIT, V4, DOI 10.3389/fncir.2010.00015
Weitz RT, 2006, NANO LETT, V6, P2810, DOI 10.1021/nl0619204
Wilson C J, 1992, Neuroimage, V1, P11, DOI 10.1016/1053-8119(92)90004-7
Wolfram S., 2002, NEW KIND SCI
Womelsdorf T, 2007, SCIENCE, V316, P1609, DOI [10.1126/science.1139597, 10.1126/science.1139178]
Woodworth A, 2004, J BIOL CHEM, V279, P10413, DOI 10.1074/jbc.M312466200
Xiao ZC, 1999, J BIOL CHEM, V274, P26511, DOI 10.1074/jbc.274.37.26511
Yamaguchi Y, 2000, CELL MOL LIFE SCI, V57, P276, DOI 10.1007/PL00000690
Yinsong W., 1991, J RADIOANAL NUCL CHE, V151, P301, DOI 10.1007/BF02035489
YOSHIDA D, 1993, J NEURO-ONCOL, V16, P109, DOI 10.1007/BF01324697
Zimmermann DR, 2008, HISTOCHEM CELL BIOL, V130, P635, DOI 10.1007/s00418-008-0485-9
NR 223
TC 5
Z9 5
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1948-7193
J9 ACS CHEM NEUROSCI
JI ACS Chem. Neurosci.
PD AUG
PY 2012
VL 3
IS 8
BP 633
EP 642
DI 10.1021/cn300097b
PG 10
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Neurosciences
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Neurosciences
& Neurology
GA 990BL
UT WOS:000307605900010
PM 23050060
ER
PT J
AU Rai, K
Hegde, AM
Jose, N
AF Rai, Kavita
Hegde, Amitha M.
Jose, Nijo
TI Salivary antioxidants and oral health in children with autism
SO ARCHIVES OF ORAL BIOLOGY
LA English
DT Article
DE Autism; Salivary antioxidants; Oral health
ID LIPID-PEROXIDATION; FREE-RADICALS; PERIODONTITIS; GINGIVAL; DISEASE
AB Individuals with autism vary widely in abilities, intelligence, and behaviours. Autistic children have preferences for soft and sweetened food making them susceptible to caries. A wide spectrum of medical and behavioural symptoms is exhibited by children with autism, which makes routine dental care very difficult in them. Mental retardation is evident in approximately 70% of individuals with autism and most psychiatric disorders including autism are associated with increased oxidative stress.
Objectives: To evaluate the oral health status of children with autism and to determine the salivary pH and total salivary antioxidant concentration (TAC).
Materials and methods: 101 subjects with autism between age group of 6 and 12 year were part of the study and 50 normal healthy siblings of same age group were taken as control group. Oral health status was analysed using oral hygiene index-simplified and dentition status index. The salivary total anti-oxidant level was estimated using phosphomolybdic acid using spectrophotometric method and the salivary pH using the pH indicating paper. The results were statistically analyzed using Mann-Whitney U test.
Results: A statistically very highly significant difference was seen in the mean oral hygiene index scores (autistic group-1.2 and control group-1, P < 0.001) and the mean salivary total antioxidant concentration (autistic group - 5.71 mu g/ml and control group - 38 mu g/ml, P < 0.001). No statistical significant difference was observed in the dental caries status and the salivary pH of autistic group and the control group.
Conclusions: Similar dental caries status was observed in children with autism and their healthy normal siblings. Oral hygiene was poor in children with autism whereas the Salivary TAC was significantly reduced in autistic children. (C) 2012 Elsevier Ltd. All rights reserved.
C1 [Rai, Kavita; Hegde, Amitha M.; Jose, Nijo] AB Shetty Mem Inst Dent Sci, Dept Pedodont & Prevent Children Dent, Mangalore, Karnataka, India.
RP Jose, N (reprint author), AB Shetty Mem Inst Dent Sci, Dept Pedodont & Prevent Children Dent, Mangalore, Karnataka, India.
EM drpedocare_rai@yahoo.co.in; amipedo@yahoo.co.in; drnijo4u@yahoo.in
CR Akalin FA, 2007, J CLIN PERIODONTOL, V34, P558, DOI 10.1111/j.1600-051X.2007.01091.x
Battino M, 2002, J CLIN PERIODONTOL, V29, P189, DOI 10.1034/j.1600-051X.2002.290301x.x
Borges I, 2007, MEDIAT INFLAMM, DOI 10.1155/2007/45794
Cenk FC, 2009, EUR J DENT, V3, P100
Chapple ILC, 1996, J CLIN PATHOL-CL MOL, V49, pM247
Cheen Y, 2008, JADA, V139, P1518
Daniela M, 2011, THER PHARM CLIN TOXI, V15, P139
DeMattei R, 2007, J Dent Hyg, V81, P65
Dorota T, 2008, PEDIAT DENT, V30, P54
Friedlander AH, 2006, J AM DENT ASSOC, V137, P1517
GUTTERIDGE JMC, 1995, CLIN CHEM, V41, P1819
Hara A, 2010, CURRENT CONCEPTS CAR, V54, P457
Klein U, 1998, AM ACAD PEDIAT DENT, V20, P312
Konopka T, 2007, ARCH IMMUNOL THER EX, V55, P417, DOI 10.1007/s00005-007-0047-1
Medina A, 2003, IJPD, V133, P130
Muthu M, 2008, J IND SOC PED PR JUN, P82
Namal Necmi, 2007, J Indian Soc Pedod Prev Dent, V25, P97
Preito B, 1999, ANAL BIOCHEM, V269, P337
Sculley DV, 2002, P NUTR SOC, V61, P137, DOI 10.1079/PNS2001141
Tsaluchidu S, 2008, BMC PSYCHIAT S1, V17, pS5
Uberos J, 2008, BRIT DENT J, V205, DOI 10.1038/sj.bdj.2008.520
Valko M, 2007, INT J BIOCHEM CELL B, V39, P44, DOI 10.1016/j.biocel.2006.07.001
Weddell J, 2004, DENT CHILD ADOLESCEN, P543
NR 23
TC 2
Z9 2
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0003-9969
J9 ARCH ORAL BIOL
JI Arch. Oral Biol.
PD AUG
PY 2012
VL 57
IS 8
BP 1116
EP 1120
DI 10.1016/j.archoralbio.2012.03.006
PG 5
WC Dentistry, Oral Surgery & Medicine
SC Dentistry, Oral Surgery & Medicine
GA 992RO
UT WOS:000307797600016
PM 22521893
ER
PT J
AU Honekopp, J
AF Hoenekopp, Johannes
TI Digit Ratio 2D:4D in Relation to Autism Spectrum Disorders, Empathizing,
and Systemizing: A Quantitative Review
SO AUTISM RESEARCH
LA English
DT Review
DE autism; digit ratio; prenatal testosterone; empathizing; systemizing;
sex differences
ID MALE BRAIN THEORY; DIRECT FINGER MEASUREMENTS; FETAL TESTOSTERONE; EYES
TEST; SEX-DIFFERENCES; 2D4D; METAANALYSIS; 2ND; 2D-4D; POPULATION
AB Prenatal testosterone (PT) effects have been proposed to increase systemizing (the drive to understand lawful inputoutput relationships), to decrease empathizing (the drive to understand others), and to cause autism via hypermasculinization of the brain. Digit ratio 2D:4D is a putative marker of PT effects in humans. An online study (n?=?1896) into the relationship between the Reading the Mind in the Eyes Test (a widely used measure of empathizing) and self-measured 2D:4D in a nonclinical sample is reported. No evidence for a link between empathizing and 2D:4D in either females or males emerged. Further, three meta-analyses are presented that look into the relationships of 2D:4D with autism spectrum disorder (ASD), systemizing, and empathizing. 2D:4D was substantially lower (more masculine) in ASD-affected individuals than in normal controls (d?=?-0.58, P?3.0.CO;2-2
Schmidt FL, 2009, BRIT J MATH STAT PSY, V62, P97, DOI 10.1348/000711007X255327
Sebat J, 2007, SCIENCE, V316, P445, DOI 10.1126/science.1138659
STEFFENBURG S, 1989, J CHILD PSYCHOL PSYC, V30, P405, DOI 10.1111/j.1469-7610.1989.tb00254.x
STROMLAND K, 1994, DEV MED CHILD NEUROL, V36, P351
Sugie Y, 2010, BRAIN DEV-JPN, V32, P356, DOI 10.1016/j.braindev.2009.05.005
Trivers R, 2006, HORM BEHAV, V49, P150, DOI 10.1016/j.yhbeh.2005.05.023
Valla JM, 2010, AUTISM RES, V3, P174, DOI 10.1002/aur.143
van Honka J, 2011, P NATL ACAD SCI USA, V108, P3448, DOI 10.1073/pnas.1011891108
Van den Bergh B, 2006, P R SOC B, V273, P2091, DOI 10.1098/rspb.2006.3550
von Horn A., 2009, SCAND J PSYCHOL, V51, P31
Voracek M, 2011, PERS INDIV DIFFER, V51, P417, DOI 10.1016/j.paid.2010.06.009
Voracek M, 2006, PERS INDIV DIFFER, V41, P1481, DOI 10.1016/j.paid.2006.06.009
Voracek M, 2010, PERS INDIV DIFFER, V48, P72, DOI 10.1016/j.paid.2009.08.019
Wakabayashi A, 2010, PERS INDIV DIFFER, V49, P928, DOI 10.1016/j.paid.2010.07.032
Zheng ZG, 2011, P NATL ACAD SCI USA, V108, P16289, DOI 10.1073/pnas.1108312108
NR 65
TC 8
Z9 8
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1939-3792
J9 AUTISM RES
JI Autism Res.
PD AUG
PY 2012
VL 5
IS 4
BP 221
EP 230
DI 10.1002/aur.1230
PG 10
WC Behavioral Sciences; Psychology, Developmental
SC Behavioral Sciences; Psychology
GA 991WF
UT WOS:000307733300001
PM 22674640
ER
PT J
AU Cascio, CJ
Moana, EJ
Guest, S
Nebel, MB
Weisner, J
Baranek, GT
Essick, GK
AF Cascio, Carissa J.
Moana-Filho, Estephan J.
Guest, Steve
Nebel, Mary Beth
Weisner, Jonathan
Baranek, Grace T.
Essick, Gregory K.
TI Perceptual and Neural Response to Affective Tactile Texture Stimulation
in Adults with Autism Spectrum Disorders
SO AUTISM RESEARCH
LA English
DT Article
DE touch; fMRI; sensory; adults; psychophysics; affective
ID HUMAN BRAIN; UNMYELINATED AFFERENTS; DEVELOPMENTAL DELAYS; SENSORY
FEATURES; SOCIAL COGNITION; FUNCTIONAL MRI; HAIRY SKIN; CHILDREN; TOUCH;
TODDLERS
AB Autism spectrum disorders (ASD) are associated with differences in sensory sensitivity and affective response to sensory stimuli, the neural basis of which is still largely unknown. We used psychophysics and functional magnetic resonance imaging (fMRI) to investigate responses to somatosensory stimulation with three textured surfaces that spanned a range of roughness and pleasantness in a sample of adults with ASD and a control group. While psychophysical ratings of roughness and pleasantness were largely similar across the two groups, the ASD group gave pleasant and unpleasant textures more extreme average ratings than did controls. In addition, their ratings for a neutral texture were more variable than controls, indicating they are less consistent in evaluating a stimulus that is affectively ambiguous. Changes in brain blood oxygenation level-dependent (BOLD) signal in response to stimulation with these textures differed substantially between the groups, with the ASD group exhibiting diminished responses compared to the control group, particularly for pleasant and neutral textures. For the most unpleasant texture, the ASD group exhibited greater BOLD response than controls in affective somatosensory processing areas such as the posterior cingulate cortex and the insula. The amplitude of response in the insula in response to the unpleasant texture was positively correlated with social impairment as measured by the Autism Diagnostic Interview-Revised (ADI-R). These results suggest that people with ASD tend to show diminished response to pleasant and neutral stimuli, and exaggerated limbic responses to unpleasant stimuli, which may contribute to diminished social reward associated with touch, perpetuating social withdrawal, and aberrant social development. Autism Res 2012,5:231244. (c) 2012 International Society for Autism Research, Wiley Periodicals, Inc.
C1 [Cascio, Carissa J.] Vanderbilt Univ, Dept Psychiat, Nashville, TN 37235 USA.
[Moana-Filho, Estephan J.; Guest, Steve; Weisner, Jonathan; Essick, Gregory K.] Univ N Carolina, Sch Dent, Ctr Neurosensory Disorders, Chapel Hill, NC USA.
[Baranek, Grace T.] Univ N Carolina, Dept Allied Hlth Sci, Div Occupat Sci & Occupat Therapy, Chapel Hill, NC USA.
[Cascio, Carissa J.] Vanderbilt Kennedy Ctr Res Human Dev, Nashville, TN USA.
[Nebel, Mary Beth] Johns Hopkins Univ, Kennedy Krieger Inst, Baltimore, MD USA.
RP Cascio, CJ (reprint author), Vanderbilt Univ, Dept Psychiat, 1601 23rd Ave S,Suite 3057, Nashville, TN 37235 USA.
EM carissa.cascio@vanderbilt.edu
RI Nebel, Mary Beth/D-3305-2015
OI Nebel, Mary Beth/0000-0003-0185-3382
FU Autism Speaks [2082]
FX This work was supported by Autism Speaks (#2082 awarded to G. K. E). The
authors wish to thank Rachael Wachter, Abigail Carroll-Sharpe, Ryan
Allred, Thomas Pardue, and John Bulluck for assistance with data
collection and management, as well as the participants who generously
shared their time and effort for this study. None of the authors have
conflicts of interest to declare.
CR American Psychiatric Association, 2000, DSM 4 TR DIAGN STAT, VFourth
Augustine JR, 1996, BRAIN RES REV, V22, P229, DOI 10.1016/S0165-0173(96)00011-2
Baranek GT, 1999, J AUTISM DEV DISORD, V29, P213, DOI 10.1023/A:1023080005650
Baranek GT, 2006, J CHILD PSYCHOL PSYC, V47, P591, DOI 10.1111/j.1469-7610.2005.01546.x
Bastiaansen J.A., BIOL PSYCHIAT, V69, P832
Ben-Sasson A, 2008, J CHILD PSYCHOL PSYC, V49, P817, DOI 10.1111/j.1469-7610.2008.01899.x
Blakemore SJ, 2006, BRAIN COGNITION, V61, P5, DOI 10.1016/j.bandc.2005.12.013
Boyd BA, 2010, AUTISM RES, V3, P78, DOI 10.1002/aur.124
Brett M., 2002, 8 INT C FUNCT MAPP H
Brownell CA, 2010, CHILD DEV, V81, P797, DOI 10.1111/j.1467-8624.2010.01434.x
Cascio C, 2008, J AUTISM DEV DISORD, V38, P127, DOI 10.1007/s10803-007-0370-8
Coskun MA, 2009, NEUROREPORT, V20, P175, DOI 10.1097/WNR.0b013e32831f47d1
Damiano C.D., 2011, 10 ANN INT M AUT RES
Dawson G, 2000, J AUTISM DEV DISORD, V30, P415, DOI 10.1023/A:1005547422749
Decety J, 2003, NEUROPSYCHOLOGIA, V41, P127, DOI 10.1016/S0028-3932(02)00143-4
Diedrichsen J, 2005, NEUROIMAGE, V27, P624, DOI 10.1016/j.neuroimage.2005.04.039
Downar J, 2002, J NEUROPHYSIOL, V87, P615
Essick GK, 2010, NEUROSCI BIOBEHAV R, V34, P192, DOI 10.1016/j.neubiorev.2009.02.003
Field T., 2001, TOUCH
Foss-Feig JH, 2012, RES AUTISM SPECT DIS, V6, P337, DOI 10.1016/j.rasd.2011.06.007
Gallese V, 2003, PSYCHOPATHOLOGY, V36, P171, DOI 10.1159/000072786
Gillott Alinda, 2007, J Intellect Disabil, V11, P359, DOI 10.1177/1744629507083585
Gordon I, 2013, HUM BRAIN MAPP, V34, P914, DOI 10.1002/hbm.21480
Guclu B, 2007, SOMATOSENS MOT RES, V24, P21, DOI 10.1080/08990220601179418
Guest S, 2009, ACTA PSYCHOL, V130, P115, DOI 10.1016/j.actpsy.2008.10.007
Guest S, 2011, ATTEN PERCEPT PSYCHO, V73, P531, DOI 10.3758/s13414-010-0037-y
Hagen MC, 2002, J NEUROPHYSIOL, V88, P1400, DOI 10.1152/jn.00940.2001
Happe F, 2006, NAT NEUROSCI, V9, P1218, DOI 10.1038/nn1770
HARLOW HF, 1962, B MENNINGER CLIN, V26, P213
Hertenstein MJ, 2006, GENET SOC GEN PSYCH, V132, P5, DOI 10.3200/MONO.132.1.5-94
Hetherington MM, 2002, APPETITE, V38, P19, DOI 10.1006/appe.2001.0442
Hilton CL, 2010, J AUTISM DEV DISORD, V40, P937, DOI 10.1007/s10803-010-0944-8
Jones RSP, 2003, J INTELLECT DEV DIS, V28, P112, DOI 10.1080/1366825031000147058
Kanner L, 1943, NERV CHILD, V2, P217
Kientz MA, 1997, AM J OCCUP THER, V51, P530
Kitada R, 2010, NEUROIMAGE, V49, P1677, DOI 10.1016/j.neuroimage.2009.09.014
Kulkarni B, 2005, EUR J NEUROSCI, V21, P3133, DOI 10.1111/j.1460-9568.2005.04098.x
Lancaster JL, 1997, HUM BRAIN MAPP, V5, P238, DOI 10.1002/(SICI)1097-0193(1997)5:4<238::AID-HBM6>3.0.CO;2-4
Lancaster JL, 2000, HUM BRAIN MAPP, V10, P120, DOI 10.1002/1097-0193(200007)10:3<120::AID-HBM30>3.0.CO;2-8
Lane AE, 2010, J AUTISM DEV DISORD, V40, P112, DOI 10.1007/s10803-009-0840-2
Le Couteur A., 2003, AUTISM DIAGNOSTIC IN
Lecanuet J.P., 2002, INTELLECTICA, V34, P29
Lieberman MD, 2009, SOC COGN AFFECT NEUR, V4, P423, DOI 10.1093/scan/nsp052
Lindgren L., 2012, NEUROIMAGE, V59, P3424
Loken LS, 2009, NAT NEUROSCI, V12, P547, DOI 10.1038/nn.2312
Loken LS, 2011, BRAIN RES, V1417, P9, DOI 10.1016/j.brainres.2011.08.011
Lord C., 1999, AUTISM DIAGNOSTIC OB
Macaluso E, 2004, NEUROIMAGE, V21, P725, DOI 10.1016/j.neuroimage.2003.09.049
MAIN M, 1981, J AM ACAD CHILD PSY, V20, P292, DOI 10.1016/S0002-7138(09)60990-0
McCabe C, 2008, SOC COGN AFFECT NEUR, V3, P97, DOI 10.1093/scan/nsn005
McGlone F., 2007, CAN J EXP PSYCHOL, V61, P171
Meltzoff AN, 2007, DEVELOPMENTAL SCI, V10, P126, DOI 10.1111/j.1467-7687.2007.00574.x
MESULAM MM, 1977, BRAIN RES, V136, P393, DOI 10.1016/0006-8993(77)90066-X
Montagu Ashley, 1986, TOUCHING HUMAN SIGNI
Morrison I, 2010, EXP BRAIN RES, V204, P305, DOI 10.1007/s00221-009-2007-y
Muller RA, 2003, AM J PSYCHIAT, V160, P1847, DOI 10.1176/appi.ajp.160.10.1847
MYERS BJ, 1984, DEV REV, V4, P240, DOI 10.1016/S0273-2297(84)80007-6
Nieuwenhuys R., 2012, INSULAR CORTEX REV
Olausson H, 2002, NAT NEUROSCI, V5, P900, DOI 10.1038/nn896
Olausson HW, 2008, NEUROSCI LETT, V436, P128, DOI 10.1016/j.neulet.2008.03.015
Pelphrey K, 2004, MENT RETARD DEV D R, V10, P259, DOI 10.1002/mrdd
Prohovnik I, 2004, PSYCHIAT RES-NEUROIM, V132, P239, DOI 10.1016/j.pscychresns.2004.03.005
Reed CL, 2005, NEUROIMAGE, V25, P718, DOI 10.1016/j.neuroimage.2004.11.044
Robins DL, 2009, BRAIN COGNITION, V69, P269, DOI 10.1016/j.bandc.2008.08.007
Rogers SJ, 2003, J AUTISM DEV DISORD, V33, P631, DOI 10.1023/B:JADD.0000006000.38991.a7
Rogers SJ, 2009, AUTISM RES, V2, P125, DOI 10.1002/aur.81
Ruby P, 2004, J COGNITIVE NEUROSCI, V16, P988, DOI 10.1162/0898929041502661
Sabatinelli D, 2011, NEUROIMAGE, V54, P2524, DOI 10.1016/j.neuroimage.2010.10.011
Sathian K, 2011, NEUROIMAGE, V57, P462, DOI 10.1016/j.neuroimage.2011.05.001
Schutz-Bosbach S, 2006, CURR BIOL, V16, P1830, DOI 10.1016/j.cub.2006.07.048
Soros P, 2007, BMC NEUROSCI, V8, DOI 10.1186/1471-2202-8-48
Spitoni GF, 2010, EXP BRAIN RES, V207, P185, DOI 10.1007/s00221-010-2446-5
Talairach J., 1988, COPLANAR STEREOTACTI
Toal F, 2010, PSYCHOL MED, V40, P1171, DOI 10.1017/S0033291709991541
Tomchek SD, 2007, AM J OCCUP THER, V61, P190
Tommerdahl M, 2007, BRAIN RES, V1154, P116, DOI 10.1016/j.brainres.2007.04.032
Towgood KJ, 2009, NEUROPSYCHOLOGIA, V47, P2981, DOI 10.1016/j.neuropsychologia.2009.06.028
Vallbo AB, 1999, J NEUROPHYSIOL, V81, P2753
Watson LR, 2011, J SPEECH LANG HEAR R, V54, P1562, DOI 10.1044/1092-4388(2011/10-0029)
Wechsler D., 2003, WECHSLER INTELLIGENC
Weiss SJ, 2000, INFANT BEHAV DEV, V23, P91, DOI 10.1016/S0163-6383(00)00030-8
Williams JHG, 2008, AUTISM RES, V1, P73, DOI 10.1002/aur.15
Wolpert DM, 1998, NAT NEUROSCI, V1, P529, DOI 10.1038/2245
NR 83
TC 16
Z9 16
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1939-3792
J9 AUTISM RES
JI Autism Res.
PD AUG
PY 2012
VL 5
IS 4
BP 231
EP 244
DI 10.1002/aur.1224
PG 14
WC Behavioral Sciences; Psychology, Developmental
SC Behavioral Sciences; Psychology
GA 991WF
UT WOS:000307733300002
PM 22447729
ER
PT J
AU Shokouhi, M
Williams, JHG
Waiter, GD
Condon, B
AF Shokouhi, Mahsa
Williams, Justin H. G.
Waiter, Gordon D.
Condon, Barrie
TI Changes in the Sulcal Size Associated With Autism Spectrum Disorder
Revealed by Sulcal Morphometry
SO AUTISM RESEARCH
LA English
DT Article
DE autism; sulcal morphometry; MRI; Brainvisa
ID CORTICAL FOLDING ABNORMALITIES; SOCIAL COGNITION; CEREBRAL-CORTEX;
BRAIN; INDIVIDUALS; VARIABILITY; DEFICITS; SYSTEM; SCALE; MRI
AB Autism spectrum disorder (ASD) is a complex, neurodevelopmental disorder with various structural abnormalities for different patient groups. Because of the heterogeneity of the disorder, several biomarkers have been suggested so far. Here, we explore the potential of sulcal surface and length as biomarkers. Three-dimensional T1-weighted images of 15 adolescents of normal intelligence with ASD and 15 age-, sex-, and intelligence quotient-matched control adolescents were analysed using Brainvisa 4.0 (http://www.brainvisa.info), which automatically extracts the cortical folds and labels them as 59 sulcal pieces. For each sulcus, the surface, length, and mean geodesic depth were computed using morphometry analysis within this software package. General linear model was conducted to compare the estimated values for the two groups, ASD and control. In the ASD group, the left insula and the right intraparietal sulcus (IPS) had significantly higher values for surface and length, respectively. Nonetheless for all sulcal pieces, the mean geodesic depth was not significantly different between the two groups. Our results suggest that sulcal surface and length can have correlation with morphological changes of cortex in ASD. Greater surface area and length in insula and IPS, respectively, may reflect greater folding. This could result in greater separation of functions with an impact upon the integrative functions of these regions. Autism Res 2012, 5: 245252. (c) 2012 International Society for Autism Research, Wiley Periodicals, Inc.
C1 [Shokouhi, Mahsa] Univ Glasgow, Dept Clin Phys & Psychol Med, Coll Med Vet & Life Sci, Glasgow, Lanark, Scotland.
[Williams, Justin H. G.] Univ Aberdeen, Sch Med, Aberdeen, Scotland.
[Waiter, Gordon D.] Univ Aberdeen, Aberdeen Biomed Imaging Ctr, Div Appl Med, Aberdeen, Scotland.
[Condon, Barrie] So Gen Hosp, Dept Clin Phys & Bioengn, Inst Neurol Sci, Glasgow G51 4TF, Lanark, Scotland.
RP Shokouhi, M (reprint author), So Gen Hosp, MRI Dept, Inst Neurol Sci, Govan Rd, Glasgow G51 4TF, Lanark, Scotland.
EM m.shokouhi.1@research.gla.ac.uk
FU SINAPSE
FX This study was supported by SINAPSE (http://www.sinapse.ac.uk).
CR Belmonte MK, 2004, J NEUROSCI, V24, P9228, DOI 10.1523/JNEUROSCI.3340-04.2004
Driemeyer J, 2008, PLOS ONE, V3, DOI 10.1371/journal.pone.0002669
Ecker C, 2010, J NEUROSCI, V30, P10612, DOI 10.1523/JNEUROSCI.5413-09.2010
Fischl B, 1999, NEUROIMAGE, V9, P195, DOI 10.1006/nimg.1998.0396
Gallese V, 2004, TRENDS COGN SCI, V8, P396, DOI 10.1016/j.tics.2004.07.002
Hadjikhani N, 2006, CEREB CORTEX, V16, P1276, DOI 10.1093/cercor/bh069
Hardan AY, 2006, AM J PSYCHIAT, V163, P1290, DOI 10.1176/appi.ajp.163.7.1290
Just MA, 2004, BRAIN, V127, P1811, DOI 10.1093/brain/awh199
Kates WR, 2009, AUTISM RES, V2, P267, DOI 10.1002/aur.98
Le Goualher G, 1999, IEEE T MED IMAGING, V18, P206, DOI 10.1109/42.764891
Levitt JG, 2003, CEREB CORTEX, V13, P728, DOI 10.1093/cercor/13.7.728
LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
Mangin JF, 1996, PROCEEDINGS OF THE IEEE WORKSHOP ON MATHEMATICAL METHODS IN BIOMEDICAL IMAGE ANALYSIS, P319, DOI 10.1109/MMBIA.1996.534084
Mangin J.-F., 2000, Proceedings IEEE Workshop on Mathematical Methods in Biomedical Image Analysis. MMBIA-2000 (Cat. No.PR00737), DOI 10.1109/MMBIA.2000.852374
Mangin J.-F., 1995, Journal of Mathematical Imaging and Vision, V5, DOI 10.1007/BF01250286
Mangin JF, 1998, LECT NOTES COMPUT SC, V1496, P1230
Mangin JF, 2004, IEEE T MED IMAGING, V23, P968, DOI 10.1109/TMI.2004.831204
McAlonan GM, 2002, BRAIN, V125, P1594, DOI 10.1093/brain/awf150
McAlonan GM, 2005, BRAIN, V128, P268, DOI 10.1093/brain/awh332
Muller KR, 2001, IEEE T NEURAL NETWOR, V12, P181, DOI 10.1109/72.914517
Nordahl CW, 2007, J NEUROSCI, V27, P11725, DOI 10.1523/JNEUROSCI.0777-07.2007
OLDFIELD RC, 1971, NEUROPSYCHOLOGIA, V9, P97, DOI 10.1016/0028-3932(71)90067-4
Ono M., 1990, ATLAS CEREBRAL SULCI
Perrot M, 2009, LECT NOTES COMPUT SC, V5636, P176, DOI 10.1007/978-3-642-02498-6_15
Perrot M., 2008, IEEE INT S BIOM IM N, p[1, 420]
Plaze M, 2011, SCHIZOPHRENIA BULL, V37, P212, DOI 10.1093/schbul/sbp081
Radua J, 2011, PSYCHOL MED, V41, P1539, DOI 10.1017/S0033291710002187
Regis J, 2005, NEUROL MED-CHIR, V45, P1, DOI 10.2176/nmc.45.1
Rojas DC, 2006, BMC PSYCHIATRY, V6, DOI 10.1186/1471-244X-6-56
Uddin LQ, 2009, NEUROSCI BIOBEHAV R, V33, P1198, DOI 10.1016/j.neubiorev.2009.06.002
Van Essen DC, 2005, NEUROIMAGE, V28, P635, DOI 10.1016/j.neuroimage.2005.06.058
Van Essen DC, 2006, J NEUROSCI, V26, P5470, DOI 10.1523/JNEUROSCI.4154-05.2006
Waiter GD, 2004, NEUROIMAGE, V22, P619, DOI 10.1016/j.neuroimage.2004.02.029
Waiter GD, 2005, NEUROIMAGE, V24, P455, DOI 10.1016/j.neuroimage.2004.08.049
WECHSLER D, 1982, REV PSYCHOL APPL, V32, P63
WECHSLER D, 1981, CONTEMP EDUC PSYCHOL, V6, P82, DOI 10.1016/0361-476X(81)90035-7
Williams JHG, 2008, AUTISM RES, V1, P73, DOI 10.1002/aur.15
Williams JHG, 2006, NEUROPSYCHOLOGIA, V44, P610, DOI 10.1016/j.neuropsychologia.2005.06.010
NR 39
TC 8
Z9 8
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1939-3792
J9 AUTISM RES
JI Autism Res.
PD AUG
PY 2012
VL 5
IS 4
BP 245
EP 252
DI 10.1002/aur.1232
PG 8
WC Behavioral Sciences; Psychology, Developmental
SC Behavioral Sciences; Psychology
GA 991WF
UT WOS:000307733300003
PM 22674695
ER
PT J
AU Key, APF
Stone, WL
AF Key, Alexandra P. F.
Stone, Wendy L.
TI Same but Different: 9-Month-Old Infants at Average and High Risk for
Autism Look at the Same Facial Features but Process Them Using Different
Brain Mechanisms
SO AUTISM RESEARCH
LA English
DT Article
DE face processing; ERP; eye tracking; infants; ASD; Vineland
ID EVENT-RELATED POTENTIALS; SPECTRUM DISORDER; GAZE BEHAVIOR;
ELECTROPHYSIOLOGICAL EVIDENCE; RECOGNITION MEMORY; YOUNGER SIBLINGS;
FACE RECOGNITION; HOME VIDEOTAPES; 1ST YEAR; CHILDREN
AB The study examined whether 9-month-old infants at average vs. high risk for autism spectrum disorder (ASD) process facial features (eyes, mouth) differently and whether such differences are related to infants' social and communicative skills. Eye tracking and visual event-related potentials (ERPs) were recorded in 35 infants (20 average-risk typical infants, 15 high-risk siblings of children with ASD) while they viewed photographs of a smiling unfamiliar female face. On 30% of the trials, the eyes or the mouth of that face was replaced with corresponding features from a different female. There were no group differences in the number, duration, or distribution of fixations, and all infants looked at the eyes and mouth regions equally. However, increased attention to the mouth was associated with weaker receptive communication skills and increased attention to the eyes correlated with better interpersonal skills. ERP results revealed that all infants detected eye and mouth changes but did so using different brain mechanisms. Changes in facial features were associated with changes in activity of the face perception mechanisms (N290) for the average-risk group but not for the high-risk infants. For all infants, correlations between ERP and eye-tracking measures indicated that larger and faster ERPs to feature changes were associated with fewer fixations on the irrelevant regions of stimuli. The size and latency of the ERP responses also correlated with parental reports of receptive and expressive communication skills, suggesting that differences in brain processing of human faces are associated with individual differences in social-communicative behaviors. Autism Res 2012, 5: 253266. (c) 2012 International Society for Autism Research, Wiley Periodicals, Inc.
C1 [Key, Alexandra P. F.] Vanderbilt Univ, Vanderbilt Kennedy Ctr Res Human Dev, Nashville, TN 37203 USA.
[Key, Alexandra P. F.] Vanderbilt Univ, Dept Hearing & Speech Sci, Nashville, TN 37203 USA.
[Stone, Wendy L.] Univ Washington, Dept Psychol, Seattle, WA 98195 USA.
[Stone, Wendy L.] Univ Washington, UW Autism Ctr, Seattle, WA 98195 USA.
RP Key, APF (reprint author), Vanderbilt Univ, Vanderbilt Kennedy Ctr, 230 Appleton Pl,Peabody Box 74, Nashville, TN 37203 USA.
EM sasha.key@vanderbilt.edu
FU Marino Autism Research Institute (MARI); NICHD [P30 HD15052]
FX The authors declare no conflict of interest. This work was supported in
part by a Marino Autism Research Institute (MARI) Discovery Award to Dr.
Alexandra Key and by NICHD Grant P30 HD15052 to Vanderbilt Kennedy
Center. We would like to thank Ms. Susan M. Williams, Ms. Stephanie
Bradshaw, and Ms. Katie Knoedelseder for their assistance in recruiting
and testing the participants.
CR Bahrick LE, 1998, CHILD DEV, V69, P1263, DOI 10.2307/1132264
Baranek GT, 1999, J AUTISM DEV DISORD, V29, P213, DOI 10.1023/A:1023080005650
Bar-Haim Y, 2006, J AUTISM DEV DISORD, V36, P131, DOI 10.1007/s10803-005-0046-1
BENJAMINI Y, 1995, J ROY STAT SOC B MET, V57, P289
Bentin S, 2006, J COGNITIVE NEUROSCI, V18, P1406, DOI 10.1162/jocn.2006.18.8.1406
Burden MJ, 2007, PEDIATRICS, V120, pE336, DOI 10.1542/peds.2006-2525
Cheour M, 1998, NAT NEUROSCI, V1, P351, DOI 10.1038/1561
COHEN J, 1992, PSYCHOL BULL, V112, P155, DOI 10.1037/0033-2909.112.1.155
COURCHESNE E, 1981, CHILD DEV, V52, P804, DOI 10.1111/j.1467-8624.1981.tb03117.x
Dalton KM, 2005, NAT NEUROSCI, V8, P519, DOI 10.1038/nn1421
Dawson G, 2005, DEV PSYCHOPATHOL, V17, P679, DOI 10.1017/S0954579405050327
deHaan M, 1997, CHILD DEV, V68, P187, DOI 10.2307/1131845
de Haan M, 2003, INT J PSYCHOPHYSIOL, V51, P45, DOI 10.1016/S0167-8760(03)00152-1
de Haan M, 2004, J CHILD PSYCHOL PSYC, V45, P1209, DOI 10.1111/j.1469-7610.2004.00320.x
Elder LM, 2008, J AUTISM DEV DISORD, V38, P1104, DOI 10.1007/s10803-007-0495-9
Elsabbagh M, 2010, TRENDS COGN SCI, V14, P81, DOI 10.1016/j.tics.2009.12.005
Elsabbagh M, 2009, BIOL PSYCHIAT, V65, P31, DOI 10.1016/j.biopsych.2008.09.034
Halit H, 2003, NEUROIMAGE, V19, P1180, DOI 10.1016/S1053-8119(03)00076-4
HOCHBERG Y, 1988, BIOMETRIKA, V75, P800, DOI 10.1093/biomet/75.4.800
Hunnius S, 2004, INFANT BEHAV DEV, V27, P397, DOI 10.1016/j.infbeh.2004.02.003
Jemel B, 2006, J AUTISM DEV DISORD, V36, P91, DOI 10.1007/s10803-005-0050-5
Joseph RM, 2003, J CHILD PSYCHOL PSYC, V44, P529, DOI 10.1111/1469-7610.00142
Key APF, 2009, INFANT CHILD DEV, V18, P149, DOI 10.1002/icd.600
Klin A, 1999, J AUTISM DEV DISORD, V29, P499, DOI 10.1023/A:1022299920240
Klin A, 2002, ARCH GEN PSYCHIAT, V59, P809, DOI 10.1001/archpsyc.59.9.809
Kuhl PK, 2006, DEVELOPMENTAL SCI, V9, pF13, DOI 10.1111/j.1467-7687.2006.00468.x
LANGDELL T, 1978, J CHILD PSYCHOL PSYC, V19, P255, DOI 10.1111/j.1469-7610.1978.tb00468.x
Lansing CR, 1999, J SPEECH LANG HEAR R, V42, P526
Luyster RJ, 2011, BRAIN TOPOGR, V24, P220, DOI 10.1007/s10548-011-0176-z
Maestro S, 2002, J AM ACAD CHILD PSY, V41, P1239, DOI 10.1097/01.CHI.0000020277.43550.02
McCleery JP, 2009, BIOL PSYCHIAT, V66, P950, DOI 10.1016/j.biopsych.2009.07.031
McPartland J, 2004, J CHILD PSYCHOL PSYC, V45, P1235, DOI 10.1111/j.1469-7610.2004.00318.x
Merin N, 2007, J AUTISM DEV DISORD, V37, P108, DOI 10.1007/s10803-006-0342-4
Nadig AS, 2007, ARCH PEDIAT ADOL MED, V161, P378, DOI 10.1001/archpedi.161.4.378
Nelson CA, 2001, INFANT CHILD DEV, V10, P3, DOI 10.1002/icd.239
OSTERLING J, 1994, J AUTISM DEV DISORD, V24, P247, DOI 10.1007/BF02172225
Osterling JA, 2002, DEV PSYCHOPATHOL, V14, P239
Ozonoff S, 2010, J AM ACAD CHILD PSY, V49, P256, DOI 10.1016/j.jaac.2009.11.009
Pascalis O, 2002, SCIENCE, V296, P1321, DOI 10.1126/science.1070223
Pelphrey KA, 2002, J AUTISM DEV DISORD, V32, P249, DOI 10.1023/A:1016374617369
Reynolds GD, 2005, DEV PSYCHOL, V41, P598, DOI 10.1037/0012-1649.41.4.598
Rogers SJ, 2009, AUTISM RES, V2, P125, DOI 10.1002/aur.81
Rozga A., 2010, J AUTISM DEV DISORD, V41, P287, DOI 10.1007/s10803-010-1051-6
Rubin D., 1987, MULTIPLE IMPUTATION
Rutherford MD, 2008, J AUTISM DEV DISORD, V38, P1371, DOI 10.1007/s10803-007-0525-7
Schwarzer G, 2005, MEM COGNITION, V33, P344, DOI 10.3758/BF03195322
Scott LS, 2006, PERCEPTION, V35, P1107, DOI 10.1068/p5493
Sparrow SS, 2005, VINELAND ADAPTIVE BE
Stone WL, 2007, ARCH PEDIAT ADOL MED, V161, P384, DOI 10.1001/archpedi.161.4.384
Taylor MJ, 2001, NEUROREPORT, V12, P1671, DOI 10.1097/00001756-200106130-00031
Thomas DG, 2004, DEV NEUROPSYCHOL, V26, P753, DOI 10.1207/s15326942dn2603_6
van der Geest JN, 2002, J CHILD PSYCHOL PSYC, V43, P669, DOI 10.1111/1469-7610.00055
Volkmar FR, 2004, J CHILD PSYCHOL PSYC, V45, P135, DOI 10.1046/j.0021-9630.2003.00317.x
VOLKMAR FR, 1989, J CHILD PSYCHOL PSYC, V30, P591, DOI 10.1111/j.1469-7610.1989.tb00270.x
Werner E, 2000, J AUTISM DEV DISORD, V30, P157, DOI 10.1023/A:1005463707029
Westfall P. H., 1993, RESAMPLING BASED MUL
Westfall P. H., 1999, MULTIPLE COMP MULTIP
Wetherby AM, 2004, J AUTISM DEV DISORD, V34, P473, DOI 10.1007/s10803-004-2544-y
Young GS, 2009, DEVELOPMENTAL SCI, V12, P798, DOI 10.1111/j.1467-7687.2009.00833.x
Zwaigenbaum L, 2005, INT J DEV NEUROSCI, V23, P143, DOI 10.1016/j.ijdevneu.2004.05.001
NR 60
TC 11
Z9 11
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1939-3792
J9 AUTISM RES
JI Autism Res.
PD AUG
PY 2012
VL 5
IS 4
BP 253
EP 266
DI 10.1002/aur.1231
PG 14
WC Behavioral Sciences; Psychology, Developmental
SC Behavioral Sciences; Psychology
GA 991WF
UT WOS:000307733300004
PM 22674669
ER
PT J
AU Shumway, S
Farmer, C
Thurm, A
Joseph, L
Black, D
Golden, C
AF Shumway, Stacy
Farmer, Cristan
Thurm, Audrey
Joseph, Lisa
Black, David
Golden, Christine
TI The ADOS Calibrated Severity Score: Relationship to Phenotypic Variables
and Stability over Time
SO AUTISM RESEARCH
LA English
DT Article
DE autism diagnostic observation schedule (ADOS); autism spectrum
disorders; severity; diagnosis
ID AUTISM SPECTRUM DISORDERS; DIAGNOSTIC OBSERVATION SCHEDULE; VALIDITY;
CHILDREN; AGE
AB Measurement of the severity of autism at a single time point, and over time, is a widespread challenge for researchers. Recently, Gotham, Pickles, and Lord published a severity metric (calibrated severity scores; CSS) that takes into account age and language level and is based on raw total scores of the Autism Diagnostic Observation Schedule (ADOS), a standardized measure commonly used in autism diagnosis. The present study examined psychometric characteristics of the CSS compared to raw scores in an independent sample of 368 children aged 2 to 12 years with autism, pervasive developmental disorder-not otherwise specified (PDD-NOS), non-spectrum delay, or typical development. Reflecting the intended calibration, the CSS were more uniformly distributed within clinical diagnostic category and across ADOS modules than were raw scores. Cross-sectional analyses examining raw and severity scores and their relationships to participant characteristics revealed that verbal developmental level was a significant predictor of raw score but accounted for significantly less variance in the CSS. Longitudinal analyses indicated overall stability of the CSS over 12 to 24 months in children with autism. Findings from this study support the use of the CSS as a more valid indicator of autism severity than the ADOS raw total score, and extend the literature by examining the stability over 12 to 24 months of the CSS in children with ASD. Autism Res 2012, 5: 267276. (c) 2012 International Society for Autism Research, Wiley Periodicals, Inc.
C1 [Shumway, Stacy; Farmer, Cristan; Thurm, Audrey; Joseph, Lisa; Black, David; Golden, Christine] NIMH, Pediat & Dev Neurosci Branch, Bethesda, MD 20892 USA.
RP Farmer, C (reprint author), NIMH, Pediat & Dev Neurosci Branch, 10 Ctr Dr,MSC 1C250, Bethesda, MD 20892 USA.
EM farmerca@mail.nih.gov
FU National Institute of Mental Health (NIMH)
FX This research was supported by the Intramural Program of the National
Institute of Mental Health (NIMH). The views expressed in this paper do
not necessarily represent the views of the NIMH, NIH, HHS, or the United
Stated Government. The authors extend their gratitude for the children
and their families who volunteered their time and efforts during the
research.
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
Bishop SL, 2011, AJIDD-AM J INTELLECT, V116, P331, DOI 10.1352/1944-7558-116.5.331
Brownell R, 2000, EXPRESSIVE ONE WORD, V3rd
Charman T, 2005, J CHILD PSYCHOL PSYC, V46, P500, DOI 10.1111/j.1469-7610.2004.00377.x
Cohen J., 2003, APPL MULTIPLE REGRES
Dawson G, 2010, PEDIATRICS, V125, pE17, DOI 10.1542/peds.2009-0958
de Bildt A, 2011, J AUTISM DEV DISORD, V41, P311, DOI 10.1007/s10803-010-1057-0
Dunn L. M., 1997, PEABODY PICTURE VOCA, V3rd
Elliott C., 2007, DIFFERENTIAL ABILITY
Fenson L, 1993, MACARTHUR COMMUNICAT
Gilliam J. E., 1995, GILLIAM AUTISM RATIN
Gotham K, 2009, J AUTISM DEV DISORD, V39, P693, DOI 10.1007/s10803-008-0674-3
Gotham K., 2008, J AM ACAD CHILD ADOL, V47, P641
Gotham K, 2007, J AUTISM DEV DISORD, V37, P613, DOI 10.1007/s10803-006-0280-1
Guy W, 1976, CLIN GLOBAL IMPRESSI
Hurt B., 2010, PEDIAT PSYCHOPHARMAC, P389
KRUG DA, 1980, J CHILD PSYCHOL PSYC, V21, P221, DOI 10.1111/j.1469-7610.1980.tb01797.x
Lord C, 2006, ARCH GEN PSYCHIAT, V63, P694, DOI 10.1001/archpsyc.63.6.694
Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
MENG XL, 1992, PSYCHOL BULL, V111, P172, DOI 10.1037/0033-2909.111.1.172
Mullen E, 1995, MULLEN SCALES EARLY
Oosterling I, 2010, J AUTISM DEV DISORD, V40, P689, DOI 10.1007/s10803-009-0915-0
Risi S, 2006, J AM ACAD CHILD PSY, V45, P1094, DOI 10.1097/01.chi.0000227880.42780.0e
Rutter M., 2003, AUTISM DIAGNOSTIC IN
Schaffer D., 1983, ARCH GEN PSYCHIAT, V40, P1228
Schopler E., 1986, CHILD AUTISM RATING
Sparrow SS, 2005, VINELAND ADAPTIVE BE
Stone WL, 1999, J CHILD PSYCHOL PSYC, V40, P219, DOI 10.1017/S0021963098003370
NR 28
TC 10
Z9 10
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1939-3792
J9 AUTISM RES
JI Autism Res.
PD AUG
PY 2012
VL 5
IS 4
BP 267
EP 276
DI 10.1002/aur.1238
PG 10
WC Behavioral Sciences; Psychology, Developmental
SC Behavioral Sciences; Psychology
GA 991WF
UT WOS:000307733300005
PM 22628087
ER
PT J
AU Van der Aa, N
Vandeweyer, G
Reyniers, E
Kenis, S
Dom, L
Mortier, G
Rooms, L
Kooy, RF
AF Van der Aa, Nathalie
Vandeweyer, Geert
Reyniers, Edwin
Kenis, Sandra
Dom, Lina
Mortier, Geert
Rooms, Liesbeth
Kooy, R. Frank
TI Haploinsufficiency of CMIP in a Girl With Autism Spectrum Disorder and
Developmental Delay due to a De Novo Deletion on Chromosome 16q23.2
SO AUTISM RESEARCH
LA English
DT Article
DE language delay; autism; ASD; CMIP; intellectual disability
ID GIANT AXONAL NEUROPATHY; C-MIP INTERACTS; LANGUAGE IMPAIRMENT;
MENTAL-RETARDATION; SPEECH; GENE; MUTATIONS; LINKAGE; FOXP1
AB In a developmentally delayed girl with an autism spectrum disorder, Single nucleotide polymorphism (SNP) array analysis showed a de novo 280?kb deletion on chromosome 16q23.2 involving two genes, GAN and CMIP. Inactivating mutations in GAN cause the autosomal recessive disorder giant axonal neuropathy, not present in our patient. CMIP was recently implicated in the etiology of specific language impairment by genome-wide association analysis. It modulates phonological short-term memory and hence plays an important role in language acquisition. Overlaps of specific language impairment and autism have been debated in the literature regarding the phenotypical language profile as well as etiology. Our patient illustrates that haploinsufficiency of CMIP may contribute to autism spectrum disorders. Our finding further supports the existence of a genetic overlap in the etiology of specific language impairment and autism. Autism Res 2012, 5: 277281. (c) 2012 International Society for Autism Research, Wiley Periodicals, Inc.
C1 [Van der Aa, Nathalie; Vandeweyer, Geert; Reyniers, Edwin; Mortier, Geert; Rooms, Liesbeth; Kooy, R. Frank] Univ Antwerp, Dept Med Genet, B-2020 Antwerp, Belgium.
[Van der Aa, Nathalie; Vandeweyer, Geert; Reyniers, Edwin; Kenis, Sandra; Mortier, Geert; Rooms, Liesbeth; Kooy, R. Frank] Univ Antwerp Hosp, Antwerp, Belgium.
[Kenis, Sandra] Univ Antwerp, Dept Neurol Childneurol, B-2020 Antwerp, Belgium.
[Dom, Lina] Paola Kinderziekenhuis, Dept Pediat Neurol, Berchem, Belgium.
RP Van der Aa, N (reprint author), Univ Edegem, Prins Boudewijnlaan 43, B-2650 Edegem, Belgium.
EM nathalie.van.der.aa@uza.be
RI Mortier, Geert/D-2542-2012
FU Belgian National Fund for Scientific Research-Flanders (FWO);
Marguerite-Marie Delacroix Foundation
FX We thank the patient and her family for their cooperation. Our work was
generously supported by grants from the Belgian National Fund for
Scientific Research-Flanders (FWO) and the Marguerite-Marie Delacroix
Foundation.
CR Abrahams BS, 2008, NAT REV GENET, V9, P341, DOI 10.1038/nrg2346
Alarcon M, 2008, AM J HUM GENET, V82, P150, DOI 10.1016/j.ajhg.2007.09.005
Anney R, 2010, HUM MOL GENET, V19, P4072, DOI 10.1093/hmg/ddq307
APA, 2000, AM PSYCH ASS DIAGN S
BISHOP DVM, 1994, PHILOS T ROY SOC B, V346, P105, DOI 10.1098/rstb.1994.0134
Buysse K, 2010, AM J MED GENET A, V152A, P2802, DOI 10.1002/ajmg.a.33508
Newbury DF, 2004, AM J HUM GENET, V74, P1225
Fisher SE, 2006, NAT REV GENET, V7, P9, DOI 10.1038/nrg1747
Geschwind DH, 2009, ANNU REV MED, V60, P367, DOI 10.1146/annurev.med.60.053107.121225
Gusev A, 2009, GENOME RES, V19, P318, DOI 10.1101/gr.081398.108
Hamdan FF, 2010, AM J HUM GENET, V87, P671, DOI 10.1016/j.ajhg.2010.09.017
Horn D, 2010, HUM MUTAT, V31, pE1851, DOI 10.1002/humu.21362
Houlden H, 2007, J NEUROL NEUROSUR PS, V78, P1267, DOI 10.1136/jnnp.2007.118968
Kamal M, 2009, MOL IMMUNOL, V46, P991, DOI 10.1016/j.molimm.2008.09.034
Kamal M, 2010, FEBS LETT, V584, P500, DOI 10.1016/j.febslet.2009.12.015
Kooy RF, 2010, MONOGR HUM GENET, V18, P126
Lai CSL, 2001, NATURE, V413, P519, DOI 10.1038/35097076
Leyfer OT, 2008, AUTISM RES, V1, P284, DOI 10.1002/aur.43
Lindgren KA, 2009, AUTISM RES, V2, P22, DOI 10.1002/aur.63
Matsuzaki H, 2009, GENOME BIOL, V10, DOI 10.1186/gb-2009-10-11-r125
Newbury DF, 2010, NEURON, V68, P309, DOI 10.1016/j.neuron.2010.10.001
Newbury DF, 2010, GENOME MED, V2, DOI 10.1186/gm127
Newbury DF, 2011, BEHAV GENET, V41, P90, DOI 10.1007/s10519-010-9424-3
Newbury DF, 2009, AM J HUM GENET, V85, P264, DOI 10.1016/j.ajhg.2009.07.004
Pennington BF, 2009, ANNU REV PSYCHOL, V60, P283, DOI 10.1146/annurev.psych.60.110707.163548
Pickles A, 2009, J CHILD PSYCHOL PSYC, V50, P843, DOI 10.1111/j.1469-7610.2008.02032.x
Pinto D, 2010, NATURE, V466, P368, DOI 10.1038/nature09146
Ramocki MB, 2008, NATURE, V455, P912, DOI 10.1038/nature07457
Robertson SP, 2005, CURR OPIN GENET DEV, V15, P301, DOI 10.1016/j.gde.2005.04.001
Rooms L, 2004, HUM MUTAT, V23, P17, DOI 10.1002/humu.10300
Scerri TS, 2011, BIOL PSYCHIAT, V70, P237, DOI 10.1016/j.biopsych.2011.02.005
Stephan DA, 2008, AM J HUM GENET, V82, P7, DOI 10.1016/j.ajhg.2007.12.003
Tager-Flusberg H, 2004, J AUTISM DEV DISORD, V34, P75, DOI 10.1023/B:JADD.0000018077.64617.5a
Vandeweyer G, 2011, BMC BIOINFORMATICS, V12, DOI 10.1186/1471-2105-12-4
Vernes SC, 2008, NEW ENGL J MED, V359, P2337, DOI 10.1056/NEJMoa0802828
Vernes SC, 2007, AM J HUM GENET, V81, P1232, DOI 10.1086/522238
Williams D, 2008, PSYCHOL BULL, V134, P944, DOI [10.1037/a0013743, 10.1037/0013743]
NR 37
TC 3
Z9 3
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1939-3792
J9 AUTISM RES
JI Autism Res.
PD AUG
PY 2012
VL 5
IS 4
BP 277
EP 281
DI 10.1002/aur.1240
PG 5
WC Behavioral Sciences; Psychology, Developmental
SC Behavioral Sciences; Psychology
GA 991WF
UT WOS:000307733300006
PM 22689534
ER
PT J
AU Song, YN
Hakoda, Y
AF Song, Yongning
Hakoda, Yuji
TI Selective Attention to Facial Emotion and Identity in Children With
Autism: Evidence for Global Identity and Local Emotion
SO AUTISM RESEARCH
LA English
DT Article
DE facial expression; facial identity; Garner paradigm; autism spectrum
disorder (ASD)
ID HIGH-FUNCTIONING AUTISM; SPECTRUM DISORDERS; ASPERGER-SYNDROME;
RECOGNITION; INFORMATION; PRECEDENCE; DEFICIT
AB The present study sought to test the global-identity and local-emotion processing hypothesis in face perception by examining emotional interference in face perception in children with high-functioning autism/Asperger's syndrome. Participants judged either the expression or the identity of faces while identity/expression was either held constant or varied (Garner paradigm). The results revealed that emotional expressions interfered with identity processing in face perception for autism spectrum disorder individuals. Taken together with previous findings, our results suggest that emotion judgment mainly depends on local processing, while identity judgment mainly depends on global processing. Autism Res 2012, 5: 282285. (c) 2012 International Society for Autism Research, Wiley Periodicals, Inc.
C1 [Song, Yongning; Hakoda, Yuji] Kyushu Univ, Fac Human Environm Studies, Fukuoka 8128581, Japan.
[Song, Yongning] E China Normal Univ, Sch Psychol & Cognit Sci, Shanghai 200062, Peoples R China.
RP Song, YN (reprint author), Kyushu Univ, Fac Human Environm Studies, 6-19-1 Hakozaki, Fukuoka 8128581, Japan.
EM yongning_song@kyudai.jp
FU Japan Society for the Promotion of Science; National Natural Foundation
of China
FX This work was supported by a Grant-in-Aid for JSPS Fellows from the
Japan Society for the Promotion of Science, and also by National Natural
Foundation of China. We declare that there is no conflict of interest in
this paper.
CR Baudouin JY, 2008, VIS COGN, V16, P933, DOI 10.1080/13506280701728990
Behrmann M, 2006, NEUROPSYCHOLOGIA, V44, P110, DOI 10.1016/j.neuropsychologia.2005.04.002
Boraston Z, 2007, NEUROPSYCHOLOGIA, V45, P1501, DOI 10.1016/j.neuropsychologia.2006.11.010
Corden B, 2008, NEUROPSYCHOLOGIA, V46, P137, DOI 10.1016/j.neuropsychologia.2007.08.005
Ehlers S, 1999, J AUTISM DEV DISORD, V29, P129, DOI 10.1023/A:1023040610384
Ellison JW, 1997, J EXP PSYCHOL HUMAN, V23, P213, DOI 10.1037/0096-1523.23.1.213
Freire A, 2000, PERCEPTION, V29, P159, DOI 10.1068/p3012
GARNER WR, 1976, COGNITIVE PSYCHOL, V8, P98, DOI 10.1016/0010-0285(76)90006-2
Gillberg C, 2001, AUTISM, V5, P57, DOI 10.1177/1362361301005001006
Happe F, 2006, J AUTISM DEV DISORD, V36, P5, DOI 10.1007/s10803-005-0039-0
Komatsu S., 2009, JAPANESE J COGNITIVE, V6, P143
Leder H, 2006, BRIT J PSYCHOL, V97, P19, DOI 10.1348/00712605X54794
Mondloch CJ, 2002, PERCEPTION, V31, P553, DOI 10.1068/p3339
NAVON D, 1977, COGNITIVE PSYCHOL, V9, P353, DOI 10.1016/0010-0285(77)90012-3
Ogawa T., 1998, TRH244 ATR
Plaisted K, 1999, J CHILD PSYCHOL PSYC, V40, P733, DOI 10.1111/1469-7610.00489
Rakover SS, 1997, PERCEPT PSYCHOPHYS, V59, P752, DOI 10.3758/BF03206021
Raven J. C., 1992, STANDARD PROGR MATRI
Schweinberger SR, 1998, J EXP PSYCHOL HUMAN, V24, P1748, DOI 10.1037/0096-1523.24.6.1748
Wallace S, 2008, COGNITION EMOTION, V22, P1353, DOI 10.1080/02699930701782153
Williams J., 2005, AUTISM, V11, P173
NR 21
TC 1
Z9 2
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1939-3792
J9 AUTISM RES
JI Autism Res.
PD AUG
PY 2012
VL 5
IS 4
BP 282
EP 285
DI 10.1002/aur.1242
PG 4
WC Behavioral Sciences; Psychology, Developmental
SC Behavioral Sciences; Psychology
GA 991WF
UT WOS:000307733300007
PM 22753237
ER
PT J
AU Ghanizadeh, A
Akhondzadeh, S
Hormozi, M
Makarem, A
Abotorabi-Zarchi, M
Firoozabadi, A
AF Ghanizadeh, A.
Akhondzadeh, S.
Hormozi, M.
Makarem, A.
Abotorabi-Zarchi, M.
Firoozabadi, A.
TI Glutathione-Related Factors and Oxidative Stress in Autism, A Review
SO CURRENT MEDICINAL CHEMISTRY
LA English
DT Review
DE Autism; oxidative stress; glutathione; treatment; inflammation;
methylation; sulfate
ID SPECTRUM DISORDERS; METABOLIC BIOMARKERS; MITOCHONDRIAL DYSFUNCTION;
ENERGY-METABOLISM; SERUM-LEVELS; CHILDREN; ANTIOXIDANT; BRAIN;
ASSOCIATION; ENZYMES
AB Autism spectrum disorders are complex neuro-developmental disorders whose neurobiology is proposed to be associated with oxidative stress which is induced by reactive oxygen species. The process of oxidative stress can be a target for therapeutic interventions. In this study, we aimed to review the role of oxidative stress, plasma glutathione (GSH), and related factors as the potential sources of damage to the brain as well as the possible related factors which reduce the oxidative stress. Methylation capacity, sulfates level, and the total glutathione level are decreased in autism. On the other hand, both oxidized glutathione and the ratio of oxidized to reduced glutathione are increased in autism. In addition, the activity of glutathione peroxidase, superoxide dismutase, and catalase, as a part of the antioxidative stress system are decreased. The current literature suggests an imbalance of oxidative and anti-oxidative stress systems in autism. Glutathione is involved in neuro-protection against oxidative stress and neuro-inflammation in autism by improving the anti-oxidative stress system. Decreasing the oxidative stress might be a potential treatment for autism.
C1 [Ghanizadeh, A.] Hafez Hosp, Dept Psychiat, Res Ctr Psychiat & Behav Sci, Shiraz, Iran.
[Ghanizadeh, A.; Firoozabadi, A.] Shiraz Univ Med Sci, Sch Med, Dept Psychiat, Shiraz, Iran.
[Akhondzadeh, S.] Univ Tehran Med Sci, Roozbeh Psychiat Hosp, Psychiat Res Ctr, Tehran 13337, Iran.
[Hormozi, M.] Fasa Univ Med Sci, Student Res Comm, Fasa, Iran.
[Makarem, A.] Jahrom Univ Med Sci, Student Res Comm, Jahrom, Iran.
[Abotorabi-Zarchi, M.] Kerman Univ Med Sci, Sch Med, Dept Neurol, Kerman, Iran.
RP Ghanizadeh, A (reprint author), Hafez Hosp, Dept Psychiat, Res Ctr Psychiat & Behav Sci, Shiraz, Iran.
EM ghanizad@sina.tums.ac.ir
CR Adams JB, 2011, NUTR METAB, V8, DOI 10.1186/1743-7075-8-34
Adams JB, 2009, J TOXICOL, DOI DOI 10.1155/2009/532640
Al-Ayadhi L. Y., 2011, NEUROCHEM RES
Alberti A, 1999, BIOL PSYCHIAT, V46, P420, DOI 10.1016/S0006-3223(98)00337-0
El-Ansary A, 2010, CLIN BIOCHEM, V43, P63, DOI 10.1016/j.clinbiochem.2009.09.008
Al-Gadani Y, 2009, CLIN BIOCHEM, V42, P1032, DOI 10.1016/j.clinbiochem.2009.03.011
Al-Mosalem OA, 2009, CLIN BIOCHEM, V42, P949, DOI 10.1016/j.clinbiochem.2009.04.006
Al-Yafee YA, 2011, BMC NEUROL, V11, DOI 10.1186/1471-2377-11-139
Asanuma M., 2011, ANN NEUROL, V67, P239
Belenky P, 2007, TRENDS BIOCHEM SCI, V32, P12, DOI 10.1016/j.tibs.2006.11.006
Blanchard K. Stephen, 2011, Reviews on Environmental Health, V26, P111, DOI 10.1515/REVEH.2011.015
Bottini N, 2001, NEUROGENETICS, V3, P111, DOI 10.1007/s100480000104
Buyske S, 2006, BMC GENET, V7, DOI 10.1186/1471-2156-7-8
Chauhan A, 2004, LIFE SCI, V75, P2539, DOI 10.1016/j.lfs.2004.04.038
Cummins I, 2011, DRUG METAB REV, V43, P266, DOI 10.3109/03602532.2011.552910
Dai RL, 2011, NEUROCHEM RES, V36, P67, DOI 10.1007/s11064-010-0264-6
Dufault R, 2009, BEHAV BRAIN FUNCT, V5, DOI 10.1186/1744-9081-5-44
Dufour-Rainfray D, 2011, NEUROSCI BIOBEHAV R, V35, P1254, DOI 10.1016/j.neubiorev.2010.12.013
Dukhande VV, 2009, BRAIN RES, V1286, P19, DOI 10.1016/j.brainres.2009.05.029
El-Fishawy P, 2010, PSYCHIAT CLIN N AM, V33, P83, DOI 10.1016/j.psc.2009.12.002
Essa MM, 2011, BIOL TRACE ELEM RES
Finkelstein JD, 1998, EUR J PEDIATR, V157, pS40, DOI 10.1007/PL00014300
FRIDOVICH I, 1983, ANNU REV PHARMACOL, V23, P239, DOI 10.1146/annurev.pa.23.040183.001323
Gawryluk JW, 2011, INT J NEUROPSYCHOPH, V14, P123, DOI 10.1017/S1461145710000805
Geier DA, 2009, J NEUROL SCI, V280, P101, DOI 10.1016/j.jns.2008.08.021
Geier DA, 2009, NEUROCHEM RES, V34, P386, DOI 10.1007/s11064-008-9782-x
Geier DA, 2007, J TOXICOL ENV HEAL A, V70, P837, DOI 10.1080/15287390701212141
Ghanizadeh A, 2011, BIOL TRACE ELEM RES, V142, P257, DOI 10.1007/s12011-010-8800-4
Ghanizadeh A, 2011, J AUTISM DEV DISORD, V41, P1591, DOI 10.1007/s10803-010-1174-9
Ghanizadeh A., 2011, ARCH MED RES, V41, P651
Ghanizadeh A, 2011, ANN NEUROL, V69, P426, DOI 10.1002/ana.22153
Ghanizadeh A, 2011, J NEUROIMMUNOL, V232, P194, DOI 10.1016/j.jneuroim.2010.10.005
Ghanizadeh A, 2011, EXPERT OPIN THER TAR, V15, P781, DOI 10.1517/14728222.2011.571212
Ghanizadeh A, 2011, NEUROSCIENCES, V16, P83
Ghanizadeh A, 2011, INT J HYPERTHER, V27, P737, DOI 10.3109/02656736.2011.604665
Ghanizadeh A, 2010, MOL GENET METAB, V101, P304, DOI 10.1016/j.ymgme.2010.07.019
Ghanizadeh A., 2011, J NEUROINFLAMM, V7, P58
Ghanizadeh A., 2011, MED HYPOTHESES
Ghanizadeh A., 2011, NEUROCHEM RES
Ghanizadeh A, 2011, TOXICOLOGY, V283, P63, DOI 10.1016/j.tox.2011.02.002
Ghanizadeh A, 2011, MOL SYNDROMOLOGY, V2, P50
Ghanizadeh A, 2011, NEUROCHEM RES, V36, P922, DOI 10.1007/s11064-010-0381-2
Ghanizadeh A., J MED HYPOT IN PRESS
Ghanizadeh A, 2011, EPILEPSY BEHAV, V20, P422, DOI 10.1016/j.yebeh.2010.12.027
Haas RH, 2010, DEV DISABIL RES REV, V16, P144, DOI 10.1002/ddrr.112
Heo JH, 2005, FREE RADICAL BIO MED, V39, P51, DOI 10.1016/j.freeadbiomed.2005.03.035
Herbert MR, 2010, CURR OPIN NEUROL, V23, P103, DOI 10.1097/WCO.0b013e328336a01f
James SJ, 2009, FASEB J, V23, P2374, DOI 10.1096/fj.08-128926
James SJ, 2009, AM J CLIN NUTR, V89, P425, DOI 10.3945/ajcn.2008.26615
James SJ, 2004, AM J CLIN NUTR, V80, P1611
James SJ, 2006, AM J MED GENET B, V141B, P947, DOI 10.1002/ajmg.b.30366
Kern JK, 2011, MED SCI MONITOR, V17, pCR677
Kern JK, 2006, J TOXICOL ENV HEAL B, V9, P485, DOI 10.1080/10937400600882079
King CR, 2011, MED HYPOTHESES, V76, P653, DOI 10.1016/j.mehy.2011.01.024
Kirsch M, 2001, FASEB J, V15, P1569, DOI 10.1096/fj.00-0823hyp
Nyska A, 2002, TOXICOL PATHOL, V30, P620, DOI 10.1080/01926230290166724
KRENITSKY TA, 1986, ARCH BIOCHEM BIOPHYS, V247, P108, DOI 10.1016/0003-9861(86)90539-4
Kurata M, 2000, COMP HAEMATOL INT, V10, P59, DOI 10.1007/s005800070009
Leoncini S, 2011, REDOX REP, V16, P145, DOI 10.1179/1351000211Y.0000000004
Lintas C, 2010, J NEUROVIROL, V16, P141, DOI 10.3109/13550281003685839
McGinnis WR, 2004, ALTERN THER HEALTH M, V10, P22
Meguid N. A., 2011, BIOL TRACE ELEM RES
Melnyk S, 2011, J AUTISM DEV DISORD
Nygren G., 2011, J AUTISM DEV DISORD
Obrenovich ME, 2011, BIOL TRACE ELEM RES, V144, P475, DOI 10.1007/s12011-011-9146-2
Oliveira G, 2005, DEV MED CHILD NEUROL, V47, P185, DOI 10.1017/S0012162205000332
Owen JB, 2010, METHODS MOL BIOL, V648, P269, DOI 10.1007/978-1-60761-756-3_18
Palmieri L, 2010, BBA-BIOENERGETICS, V1797, P1130, DOI 10.1016/j.bbabio.2010.04.018
Persico AM, 2000, AM J MED GENET, V96, P784, DOI 10.1002/1096-8628(20001204)96:6<784::AID-AJMG18>3.0.CO;2-7
Pocernich C.B., 2011, BIOCH BIOPHYS ACTA
Pons R, 2004, J PEDIATR-US, V144, P81, DOI 10.1016/j.jpeds.2003.10.023
Shinohe A, 2006, PROG NEURO-PSYCHOPH, V30, P1472, DOI 10.1016/j.pnpbp.2006.06.013
Sipkens J. A., ATHEROSCLER IN PRESS, V221, P48
State MW, 2011, NAT NEUROSCI, V14, P1499, DOI 10.1038/nn.2924
Theoharides TC, 2011, J NEUROINFLAMM, V8, DOI 10.1186/1742-2094-8-168
Vitvitsky V, 2006, J BIOL CHEM, V281, P35785, DOI 10.1074/jbc.M602799200
Vojdani A, 2008, J NEUROIMMUNOL, V205, P148, DOI 10.1016/j.jneuroim.2008.09.005
Weissman JR, 2008, PLOS ONE, V3, DOI 10.1371/journal.pone.0003815
Yorbik O, 2002, PROSTAG LEUKOTR ESS, V67, P341, DOI 10.1054/plef.439
Zhu YG, 2006, BRAIN RES, V1090, P35, DOI 10.1016/j.brainres.2006.03.063
Zoroglu SS, 2004, EUR ARCH PSY CLIN N, V254, P143, DOI 10.1007/s00406-004-0456-7
NR 81
TC 20
Z9 20
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
EMIRATES
SN 0929-8673
J9 CURR MED CHEM
JI Curr. Med. Chem.
PD AUG
PY 2012
VL 19
IS 23
BP 4000
EP 4005
PG 6
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Pharmacology &
Pharmacy
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy
GA 993HQ
UT WOS:000307848800014
PM 22708999
ER
PT J
AU Lynch, SA
Nguyen, LS
Ng, LY
Waldron, M
McDonald, D
Gecz, J
AF Lynch, Sally Ann
Lam Son Nguyen
Ng, Li Yen
Waldron, Mary
McDonald, Denise
Gecz, Jozef
TI Broadening the phenotype associated with mutations in UPF3B: Two further
cases with renal dysplasia and variable developmental delay
SO EUROPEAN JOURNAL OF MEDICAL GENETICS
LA English
DT Article
DE UPF3B; Renal dysplasia; Autistic spectrum disorder; Macrocephaly
ID COMPLEX
AB We present two brothers with mutations in UPF3B, an X-linked intellectual disability gene. Our family consists of two affected brothers and a carrier mother. Both affected brothers had renal dysplasia. A maternal uncle died from a congenital heart defect at 4 months. The two boys had variable degrees of developmental delay. One had macrocephaly, significant expressive speech delay and constipation. The other brother had normocephaly, obsessional tendencies and was diagnosed with high functioning autism. The phenotypically normal mother had 100% skewed X-inactivation. Our cases expand the phenotype seen with UPF3B mutations and highlight the variability within families. (c) 2012 Elsevier Masson SAS. All rights reserved.
C1 [Lynch, Sally Ann; Ng, Li Yen] Our Ladys Childrens Hosp, Natl Ctr Med Genet, Dublin 12, Ireland.
[Lam Son Nguyen; Gecz, Jozef] Univ Adelaide, Sch Paediat & Reprod Hlth, Adelaide, SA 5001, Australia.
[Gecz, Jozef] Womens & Childrens Hosp, SA Pathol, Adelaide, SA 5006, Australia.
[McDonald, Denise] AMNCH Hosp Tallaght, Dublin 24, Ireland.
RP Lynch, SA (reprint author), Our Ladys Childrens Hosp, Natl Ctr Med Genet, Dublin 12, Ireland.
EM Sallyann.lynch@olchc.ie
CR Addington AM, 2011, MOL PSYCHIATR, V16, P238, DOI 10.1038/mp.2010.59
Chan WK, 2009, NAT STRUCT MOL BIOL, V16, P747, DOI 10.1038/nsmb.1612
Dekel B, 2003, NEPHRON EXP NEPHROL, V95, pE1, DOI 10.1159/000073017
Gehring NH, 2003, MOL CELL, V11, P939, DOI 10.1016/S1097-2765(03)00142-4
Graham JM, 1998, AM J MED GENET, V80, P145
Laumonnier F, 2010, MOL PSYCHIATR, V15, P767, DOI 10.1038/mp.2009.14
Nguyen L. S., 2011, MOL PSYCHIAT
Sorocos K., 2011, J UROLOGY, V186, P1437
Szyszka P., 2011, PSYCHIAT GENET
Tarpey PS, 2007, NAT GENET, V39, P1127, DOI 10.1038/ng2100
NR 10
TC 4
Z9 4
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1769-7212
J9 EUR J MED GENET
JI Eur. J. Med. Genet.
PD AUG-SEP
PY 2012
VL 55
IS 8-9
BP 476
EP 479
DI 10.1016/j.ejmg.2012.03.010
PG 4
WC Genetics & Heredity
SC Genetics & Heredity
GA 989DN
UT WOS:000307540600007
PM 22609145
ER
PT J
AU Krumm, N
Sudmant, PH
Ko, A
O'Roak, BJ
Malig, M
Coe, BP
Quinlan, AR
Nickerson, DA
Eichler, EE
AF Krumm, Niklas
Sudmant, Peter H.
Ko, Arthur
O'Roak, Brian J.
Malig, Maika
Coe, Bradley P.
Quinlan, Aaron R.
Nickerson, Deborah A.
Eichler, Evan E.
CA NHLBI Exome Sequencing Project
TI Copy number variation detection and genotyping from exome sequence data
SO GENOME RESEARCH
LA English
DT Article
ID STRUCTURAL VARIATION; HUMAN GENOME; VARIANTS; AUTISM
AB While exome sequencing is readily amenable to single-nucleotide variant discovery, the sparse and nonuniform nature of the exome capture reaction has hindered exome-based detection and characterization of genic copy number variation. We developed a novel method using singular value decomposition (SVD) normalization to discover rare genic copy number variants (CNVs) as well as genotype copy number polymorphic (CNP) loci with high sensitivity and specificity from exome sequencing data. We estimate the precision of our algorithm using 122 trios (366 exomes) and show that this method can be used to reliably predict (94% overall precision) both de novo and inherited rare CNVs involving three or more consecutive exons. We demonstrate that exome-based genotyping of CNPs strongly correlates with whole-genome data (median r(2) = 0.91), especially for loci with fewer than eight copies, and can estimate the absolute copy number of multi-allelic genes with high accuracy (78% call level). The resulting user-friendly computational pipeline, CoNIFER (copy number inference from exome reads), can reliably be used to discover disruptive genic CNVs missed by standard approaches and should have broad application in human genetic studies of disease.
C1 [Krumm, Niklas; Sudmant, Peter H.; Ko, Arthur; O'Roak, Brian J.; Malig, Maika; Coe, Bradley P.; Nickerson, Deborah A.; Eichler, Evan E.] Univ Washington, Sch Med, Dept Genome Sci, Seattle, WA 98195 USA.
[NHLBI Exome Sequencing Project] NHLBI, NHLBI Exome Sequencing Project, NIH, Bethesda, MD 20892 USA.
[Quinlan, Aaron R.] Univ Virginia, Ctr Publ Hlth Gen, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA.
[Eichler, Evan E.] Univ Washington, Howard Hughes Med Inst, Seattle, WA 98195 USA.
RP Eichler, EE (reprint author), Univ Washington, Sch Med, Dept Genome Sci, Seattle, WA 98195 USA.
EM eee@gs.washington.edu
FU NIH [HD065285, HHSN273200800010C, HL102926]; Simons Foundation Autism
Research Initiative
FX We thank S. Ng, S. McGee, and T. Brown for helpful comments in the
preparation of this manuscript; M. State and the Simons Simplex
Collection Genetics Consortium for providing Illumina genotyping data;
K. Patterson for exome coverage statistics; and A. Schachtel for
suggesting the CoNIFER name. This work was supported by NIH grants
HD065285 (E.E.E.), HHSN273200800010C (D.A.N.), and HL102926 (D.A.N.) and
the Simons Foundation Autism Research Initiative (E.E.E.). E.E.E. is an
investigator of the Howard Hughes Medical Institute.
CR Alkan C, 2009, NAT GENET, V41, P1061, DOI 10.1038/ng.437
Bamshad MJ, 2011, NAT REV GENET, V12, P745, DOI 10.1038/nrg3031
Campbell CD, 2011, AM J HUM GENET, V88, P317, DOI 10.1016/j.ajhg.2011.02.004
Chiang D. Y., 2008, NAT METHODS, V6, P99
Conrad DF, 2011, NATURE, V464, P704
Girirajan S, 2010, ANNU REV GENET, V45, P203
Hach F, 2010, NAT METHODS, V7, P576, DOI 10.1038/nmeth0810-576
Hormozdiari F, 2009, GENOME RES, V19, P1270, DOI 10.1101/gr.088633.108
Karakoc E, 2012, NAT METHODS, V9, P176, DOI [10.1038/nmeth.1810, 10.1038/NMETH.1810]
Kidd JM, 2008, NATURE, V453, P56, DOI 10.1038/nature06862
Korbel JO, 2009, GENOME BIOL, V10, DOI 10.1186/gb-2009-10-2-r23
Korbel JO, 2007, P NATL ACAD SCI USA, V104, P10110, DOI 10.1073/pnas.0703834104
Mortazavi A, 2008, NAT METHODS, V5, P621, DOI 10.1038/nmeth.1226
Ng S. B., 2009, NAT GENET, V42, P30
O'Roak BJ, 2012, NATURE, V485, P246, DOI 10.1038/nature10989
Sanders SJ, 2011, NEURON, V70, P863, DOI 10.1016/j.neuron.2011.05.002
Santos Dos C, 2004, NAT GENET 0527, V36, P720
Sathirapongsasuti JF, 2011, BIOINFORMATICS, V27, P2648, DOI 10.1093/bioinformatics/btr462
Sudmant PH, 2010, SCIENCE, V330, P641, DOI 10.1126/science.1197005
Altshuler D, 2010, NATURE, V467, P1061, DOI 10.1038/nature09534
Ye K, 2009, BIOINFORMATICS, V25, P2865, DOI 10.1093/bioinformatics/btp394
Yoon ST, 2009, GENOME RES, V19, P1586, DOI 10.1101/gr.092981.109
NR 22
TC 84
Z9 86
PU COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
PI COLD SPRING HARBOR
PA 1 BUNGTOWN RD, COLD SPRING HARBOR, NY 11724 USA
SN 1088-9051
J9 GENOME RES
JI Genome Res.
PD AUG
PY 2012
VL 22
IS 8
BP 1525
EP 1532
DI 10.1101/gr.138115.112
PG 8
WC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology;
Genetics & Heredity
SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology;
Genetics & Heredity
GA 983BD
UT WOS:000307090300014
PM 22585873
ER
PT J
AU Leach, PT
Poplawski, SG
Kenney, JW
Hoffman, B
Liebermann, DA
Abel, T
Gould, TJ
AF Leach, Prescott T.
Poplawski, Shane G.
Kenney, Justin W.
Hoffman, Barbara
Liebermann, Dan A.
Abel, Ted
Gould, Thomas J.
TI Gadd45b knockout mice exhibit selective deficits in
hippocampus-dependent long-term memory
SO LEARNING & MEMORY
LA English
DT Article
ID IMMEDIATE-EARLY GENES; DNA DEMETHYLATION; SYNAPTIC CONSOLIDATION;
COGNITIVE NEUROSCIENCE; GLUTAMATE RECEPTORS; PROTEIN-SYNTHESIS;
NERVOUS-SYSTEM; DENTATE GYRUS; FEAR; PLASTICITY
AB Growth arrest and DNA damage-inducible beta (Gadd45b) has been shown to be involved in DNA demethylation and may be important for cognitive processes. Gadd45b is abnormally expressed in subjects with autism and psychosis, two disorders associated with cognitive deficits. Furthermore, several high-throughput screens have identified Gadd45b as a candidate plasticity-related gene. However, a direct demonstration of a link between Gadd45b and memory has not been established. The current studies first determined whether expression of the Gadd45 family of genes was affected by contextual fear conditioning. Gadd45b, and to a lesser extent Gadd45g, were up-regulated in the hippocampus following contextual fear conditioning, whereas Gadd45a was not. Next, Gadd45b knockout mice were tested for contextual and cued fear conditioning. Gadd45b knockout mice exhibited a significant deficit in long-term contextual fear conditioning; however, they displayed normal levels of short-term contextual fear conditioning. No differences between Gadd45b knockout and wild-type mice were observed in cued fear conditioning. Because cued fear conditioning is hippocampus independent, while contextual fear conditioning is hippocampus dependent, the current studies suggest that Gadd45b may be important for long-term hippocampus-dependent memory storage. Therefore, Gadd45b may be a novel therapeutic target for the cognitive deficits associated with many neurodevelopmental, neurological, and psychiatric disorders.
C1 [Leach, Prescott T.; Gould, Thomas J.] Temple Univ, Dept Psychol, Neurosci Program, Philadelphia, PA 19122 USA.
[Poplawski, Shane G.; Abel, Ted] Univ Penn, Dept Biol, Dept Pharmacol, Philadelphia, PA 19104 USA.
[Kenney, Justin W.] Univ Southampton, Sch Biol Sci, Southampton S017 1BJ, Hants, England.
[Hoffman, Barbara; Liebermann, Dan A.] Temple Univ, Fels Inst Canc Res & Mol Biol, Sch Med, Philadelphia, PA 19140 USA.
RP Gould, TJ (reprint author), Temple Univ, Dept Psychol, Neurosci Program, Philadelphia, PA 19122 USA.
EM tgould@temple.edu
FU National Institute on Drug Abuse [DA017949]; National Institute of
Mental Health [MH087463]; NIH-NIDA training grant [DA07237]; [GM008076]
FX This work was funded with grant support from the National Institute on
Drug Abuse (T.J.G., DA017949) and the National Institute of Mental
Health (T.A., MH087463). P.T.L. and J.W.K. were supported by NIH-NIDA
training grant DA07237 and S.G.P. was supported by training grant
GM008076. We thank Josh Hawk for his assistance in tissue collections,
and Kristy A. Cordero and Leonardo A. Ortega for their help with
breeding, colony maintenance, and genotyping. We also thank Tatiana M.
Kazdoba for reading and commenting on early drafts of this manuscript.
CR ABDOLLAHI A, 1991, ONCOGENE, V6, P165
Abel T, 1997, CELL, V88, P615, DOI 10.1016/S0092-8674(00)81904-2
Akshoomoff N, 2005, DEV NEUROPSYCHOL, V27, P307, DOI 10.1207/s15326942dn2703_1
Aman MG, 2008, J CHILD ADOL PSYCHOP, V18, P227, DOI 10.1089/cap.2007.0133
Anagnostaras SG, 1999, NEUROPSYCHOPHARMACOL, V21, P731, DOI 10.1016/S0893-133X(99)00083-4
Bailey A, 1998, BRAIN, V121, P889, DOI 10.1093/brain/121.5.889
Barch DM, 2005, ANNU REV CLIN PSYCHO, V1, P321, DOI 10.1146/annurev.clinpsy.1.102803.143959
Barnard L, 2002, J PSYCHOPHARMACOL, V16, P93
Baron-Cohen S, 2004, J NEUROL NEUROSUR PS, V75, P945, DOI 10.1136/jnnp.2003.018713
Barreto G, 2007, NATURE, V445, P671, DOI 10.1038/nature05515
BENARI Y, 1990, TRENDS NEUROSCI, V13, P312, DOI 10.1016/0166-2236(90)90135-W
BLANCHAR.RJ, 1969, J COMP PHYSIOL PSYCH, V67, P370, DOI 10.1037/h0026779
BLISS TVP, 1993, NATURE, V361, P31, DOI 10.1038/361031a0
Bourtchouladze R, 1998, LEARN MEMORY, V5, P365
BOURTCHULADZE R, 1994, CELL, V79, P59, DOI 10.1016/0092-8674(94)90400-6
Bramham CR, 2005, PROG NEUROBIOL, V76, P99, DOI 10.1016/j.pneurobio.2005.06.003
Bruel-Jungerman E, 2007, NEUROSCIENTIST, V13, P492, DOI 10.1177/1073858407302725
Conner DA, 2002, CURR PROTOC MOL BIOL, DOI [10.1002/0471142727.mb2308s57, DOI 10.1002/0471142727.MB2308S57]
Czerniawski J, 2011, J NEUROSCI, V31, P11200, DOI 10.1523/JNEUROSCI.2211-11.2011
Garbett K, 2008, NEUROBIOL DIS, V30, P303, DOI 10.1016/j.nbd.2008.01.012
Gavin D.P., 2011, NEUROPSYCHOPHARMACOL, V37, P531
Gavin DP, 2011, 68120 SOC NEUR
Goeldner C, 2009, NEUROBIOL LEARN MEM, V91, P393, DOI 10.1016/j.nlm.2008.12.001
Gould TJ, 2002, BEHAV PHARMACOL, V13, P287
Gould TJ, 2005, LEARN MEMORY, V12, P389, DOI 10.1101/lm.89105
Gupta M, 2005, ONCOGENE, V24, P7170, DOI 10.1038/sj.onc.1208847
Hall J, 2000, NAT NEUROSCI, V3, P533
Hevroni D, 1998, J MOL NEUROSCI, V10, P75, DOI 10.1007/BF02737120
Keeley MB, 2006, LEARN MEMORY, V13, P135, DOI 10.1101/lm.86906
Kenney JW, 2010, NEUROPSYCHOPHARMACOL, V35, P483, DOI 10.1038/npp.2009.153
Lemberger T, 2008, FASEB J, V22, P2872, DOI 10.1096/fj.08-107888
Liebermann DA, 1998, ONCOGENE, V17, P3319
Linnarsson S, 1997, EUR J NEUROSCI, V9, P2581, DOI 10.1111/j.1460-9568.1997.tb01687.x
Logue SE, 1997, BEHAV NEUROSCI, V111, P104, DOI 10.1037/0735-7044.111.1.104
Lu Y, 2008, NEUROBIOL LEARN MEM, V89, P312, DOI 10.1016/j.nlm.2007.08.018
Lubin FD, 2008, J NEUROSCI, V28, P10576, DOI 10.1523/JNEUROSCI.1786-08.2008
Ma DK, 2009, SCIENCE, V323, P1074, DOI 10.1126/science.1166859
Ma DKK, 2009, CELL CYCLE, V8, P1526
Matrisciano F, 2011, MOL PHARMACOL, V80, P174, DOI 10.1124/mol.110.070896
Mill J, 2008, AM J HUM GENET, V82, P696, DOI 10.1016/j.ajhg.2008.01.008
MOSER E, 1993, NEUROREPORT, V5, P317, DOI 10.1097/00001756-199312000-00035
NEDIVI E, 1993, NATURE, V363, P718, DOI 10.1038/363718a0
Nguyen A, 2010, FASEB J, V24, P3036, DOI [10.1096/fj.10-154484, 10.1096/fj.09-154484]
Nikolov R, 2006, REV BRAS PSIQUIATR, V28, pS39, DOI 10.1590/S1516-44462006000500006
Perez-Cadahia B, 2011, BIOCHEM CELL BIOL, V89, P61, DOI 10.1139/O10-138
PHILLIPS RG, 1992, BEHAV NEUROSCI, V106, P274, DOI 10.1037//0735-7044.106.2.274
Pidsley R, 2011, BIOL PSYCHIAT, V69, P146, DOI 10.1016/j.biopsych.2010.03.029
Ploski JE, 2006, J NEUROCHEM, V99, P1122, DOI 10.1111/j.1471-4159.2006.04156.x
Rai K, 2008, CELL, V135, P1201, DOI 10.1016/j.cell.2008.11.042
SHENG M, 1990, NEURON, V4, P477, DOI 10.1016/0896-6273(90)90106-P
Soule J, 2006, BIOCHEM SOC T, V34, P600
Stranahan AM, 2007, HIPPOCAMPUS, V17, P1017, DOI 10.1002/hipo.20348
Vecsey CG, 2007, J NEUROSCI, V27, P6128, DOI 10.1523/JNEUROSCI.0296-07.2007
Wu H, 2009, SCI SIGNAL, V2, DOI 10.1126/scisignal.264pe17
Yu NK, 2011, MOL BRAIN, V4, DOI 10.1186/1756-6606-4-5
NR 55
TC 16
Z9 16
PU COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
PI COLD SPRING HARBOR
PA 1 BUNGTOWN RD, COLD SPRING HARBOR, NY 11724 USA
SN 1072-0502
J9 LEARN MEMORY
JI Learn. Mem.
PD AUG
PY 2012
VL 19
IS 8
BP 319
EP 324
DI 10.1101/lm.024984.111
PG 6
WC Neurosciences; Psychology, Experimental
SC Neurosciences & Neurology; Psychology
GA 991LV
UT WOS:000307703600002
PM 22802593
ER
PT J
AU Grandgeorge, M
Tordjman, S
Lazartigues, A
Lemonnier, E
Deleau, M
Hausberger, M
AF Grandgeorge, Marine
Tordjman, Sylvie
Lazartigues, Alain
Lemonnier, Eric
Deleau, Michel
Hausberger, Martine
TI Does Pet Arrival Trigger Prosocial Behaviors in Individuals with Autism?
SO PLOS ONE
LA English
DT Article
ID PERVASIVE DEVELOPMENTAL DISORDERS; ANIMAL-ASSISTED THERAPY;
SOCIAL-INTERACTION; DIAGNOSTIC INTERVIEW; FACILITATED THERAPY; SPECTRUM
DISORDERS; EARLY RECOGNITION; JOINT ATTENTION; CHILDREN; OWNERSHIP
AB Alteration of social interactions especially prosocial behaviors - an important aspect of development - is one of the characteristics of autistic disorders. Numerous strategies or therapies are used to improve communication skills or at least to reduce social impairments. Animal-assisted therapies are used widely but their relevant benefits have never been scientifically evaluated. In the present study, we evaluated the association between the presence or the arrival of pets in families with an individual with autism and the changes in his or her prosocial behaviors. Of 260 individuals with autism - on the basis of presence or absence of pets - two groups of 12 individuals and two groups of 8 individuals were assigned to: study 1 (pet arrival after age of 5 versus no pet) and study 2 (pet versus no pet), respectively. Evaluation of social impairment was assessed at two time periods using the 36-items ADI-R algorithm and a parental questionnaire about their child-pet relationships. The results showed that 2 of the 36 items changed positively between the age of 4 to 5 (t(0)) and time of assessment (t(1)) in the pet arrival group (study 1): "offering to share" and "offering comfort". Interestingly, these two items reflect prosocial behaviors. There seemed to be no significant changes in any item for the three other groups. The interactions between individuals with autism and their pets were more - qualitatively and quantitatively - reported in the situation of pet arrival than pet presence since birth. These findings open further lines of research on the impact of pet's presence or arrival in families with an individual with autism. Given the potential ability of individuals with autism to develop prosocial behaviors, related studies are needed to better understand the mechanisms involved in the development of such child-pet relationship.
C1 [Grandgeorge, Marine; Lazartigues, Alain; Lemonnier, Eric] CHRU Brest, Hop Bohars, Ctr Ressources Autisme, Bohars, France.
[Grandgeorge, Marine; Hausberger, Martine] CNRS, UMR 6552, Lab Ethol Anim & Humaine, Rennes, France.
[Tordjman, Sylvie] CHRU Guillaume Regnier, Rennes, France.
[Deleau, Michel] Ctr Rech Psychol Cognit & Commun, Rennes, France.
RP Grandgeorge, M (reprint author), CHRU Brest, Hop Bohars, Ctr Ressources Autisme, Bohars, France.
EM marine.grandgeorge@chu-brest.fr
FU Adrienne and Pierre Sommer Foundation; Fondation Sommer
FX The Adrienne and Pierre Sommer Foundation gave the financial support for
this study. The funders had no role in study design, data collection and
analysis, decision to publish, or preparation of the manuscript. The
authors declare that they have no financial interests.We are thankful to
Dr. Ann Cloarec, researcher, Ethos laboratory and Zarrin Alavi, (for her
pertinent advice) medical writer and translator, Brest University
Hospital, Department of Internal Medicine and Chest Diseases; INSERM CIC
0502, to Pr Michel Botbol, CHRU Brest, to families for their
participation, to the Fondation Sommer for their support and the French
GIS CCS (Groupe d'Interet Scientifique - Comportement Cerveau et
Societe)
CR American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th
Anastasi A., 1988, PSYCHOL TESTING
ANDERSON WP, 1992, MED J AUSTRALIA, V157, P298
Bailey C, 1988, DISS ABSTR INT, V48
Baranek GT, 1999, J AUTISM DEV DISORD, V29, P213, DOI 10.1023/A:1023080005650
Barker SB, 2008, J VET MED EDUC, V35, P487, DOI 10.3138/jvme.35.4.487
BARONCOHEN S, 1985, COGNITION, V21, P37, DOI 10.1016/0010-0277(85)90022-8
Baron-Cohen Simon, 1995, MINDBLINDNESS ESSAY
Bass M, 2009, J AUTISM DEV DISORD, V39, P1261, DOI 10.1007/s10803-009-0734-3
Beck AM, 1996, ANNU REV PUBL HEALTH, V17, P247, DOI 10.1146/annurev.pu.17.050196.001335
BECK AM, 1984, J AM VET MED ASSOC, V184, P414
Beck AM, 2001, ANTHROZOOS, V14, P19
Blue GF, 1986, CHILDHOOD ED, V63, P84
BRICKEL CM, 1982, PSYCHOL REP, V50, P71
BRUNER JS, 1972, AM PSYCHOL, V27, P687, DOI 10.1037/h0033144
Bryant B, 1986, RELEVANCE FAMILY NEI
Bryant B. K., 1990, Anthrozoös, V3, P253
Burrows KE, 2008, QUAL HEALTH RES, V18, P1642, DOI 10.1177/1049732308327088
Cain A. O., 1985, MARRIAGE FAM REV, V8, P5, DOI 10.1300/J002v08n03_02
Celani G, 2002, AUTISM, V6, P93, DOI 10.1177/1362361302006001007
Endenburg N, 1996, WALTHAM BOOK HUMAN A, p[1996, 7]
epperberg IM, 1991, J COMP PSYCHOL, V105, P286
FILIATRE JC, 1986, BEHAV PROCESS, V12, P33, DOI 10.1016/0376-6357(86)90068-9
Filiatre J. C., 1988, Anthrozoös, V2, P22
FRIEDMANN E, 1983, J NERV MENT DIS, V171, P461, DOI 10.1097/00005053-198308000-00002
FRIEDMANN E, 1980, PUBLIC HEALTH REP, V95, P307
Furman W., 1989, CHILDRENS SOCIAL NET, P151
Gasalberti Denise, 2006, J Pediatr Health Care, V20, P133, DOI 10.1016/j.pedhc.2005.12.015
George H, 1988, INNOVATIVE INTERVENT, P400
Gervais H, 2004, NAT NEUROSCI, V7, P801, DOI 10.1038/nn1291
Glascoe FP, 2005, MENT RETARD DEV D R, V11, P173, DOI 10.1002/mrdd.20068
Glascoe FP, 1997, PEDIATRICS, V99, P830, DOI 10.1542/peds.99.6.830
Grandgeorge M, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0004683
Grandgeorge M, 2010, COULD BOND ANIMAL AL, V2
Haggerty Davis J, 1989, ANTHROZOOS, V2, P189
Hills AM, 1995, ANTHROZOOS, V8, P132
Hinde R. A., 1979, UNDERSTANDING RELATI
Kaminski M, 2002, CHILD HEALTH CARE, V31, P321, DOI 10.1207/S15326888CHC3104_5
KASARI C, 1990, J AUTISM DEV DISORD, V20, P87, DOI 10.1007/BF02206859
Katcher A., 2000, HDB ANIMAL ASSISTED, P461
Kenzer AL, 2011, RES AUTISM SPECT DIS, V5, P819, DOI 10.1016/j.rasd.2010.09.011
KIDD AH, 1985, PSYCHOL REP, V57, P15
Levinson BM, 1962, MENT HYG, V179, P46
Lord C, 1997, J AUTISM DEV DISORD, V27, P501, DOI 10.1023/A:1025873925661
LORD C, 1989, J AUTISM DEV DISORD, V19, P185, DOI 10.1007/BF02211841
LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
Macdonald A, 1981, INTERRELATIONS PEOPL
Martin F, 2002, WESTERN J NURS RES, V24, P657, DOI 10.1177/019394502236639
Maurer M, 2011, PSYCHIAT ENFANT, V54, P575
Maurer M, 2010, ANTHROZOOS, V23, P383, DOI 10.2752/175303710X12750451259453
McConnell SR, 2002, J AUTISM DEV DISORD, V32, P351, DOI 10.1023/A:1020537805154
Melson G., 2005, WHY WILD THINGS ARE
Melson Gail F., 1991, CHILDRENS ENV Q, V8, P55
MILLOT JL, 1986, APPL ANIM BEHAV SCI, V16, P383, DOI 10.1016/0168-1591(86)90010-9
MILLOT JL, 1988, BEHAV PROCESS, V17, P1, DOI 10.1016/0376-6357(88)90046-0
Montagner H, 1995, ENFANT ANIMAL ECOLE
MUNDY P, 1995, DEV PSYCHOPATHOL, V7, P63
NATHANSON DE, 1993, ANTHROZOOS, V6, P17
Odendaal JSJ, 2000, J PSYCHOSOM RES, V49, P275, DOI 10.1016/S0022-3999(00)00183-5
OSTERLING J, 1994, J AUTISM DEV DISORD, V24, P247, DOI 10.1007/BF02172225
Osterling JA, 2002, DEV PSYCHOPATHOL, V14, P239
Paul ES, 1996, APPL ANIM BEHAV SCI, V47, P17, DOI 10.1016/0168-1591(95)01007-6
Piaget J, 1962, PLAY DREAMS IMITATIO
Pierce K, 1997, J APPL BEHAV ANAL, V30, P157, DOI 10.1901/jaba.1997.30-157
Poresky RH, 1989, COMPANION ANIMAL BON
Poresky RH, 1996, ANTHROZOOS, V9, P159
Poulin-Dubois D, 2006, J COGN DEV, V7, P431, DOI 10.1207/s15327647jcd0704_1
RALLS K, 1985, CAN J ZOOL, V63, P1050
REDEFER LA, 1989, J AUTISM DEV DISORD, V19, P461, DOI 10.1007/BF02212943
Roge B, 2009, ADAPTATION FRANCAISE
SALOMON A, 1981, CAN MENT HEALTH, V29, P9
Savage-Rumbaugh Sue, 1994, KANZI APE BRINK HUMA
SERPELL J, 1991, J ROY SOC MED, V84, P717
SIEGEL B, 1986, J AUTISM DEV DISORD, V16, P275, DOI 10.1007/BF01531660
Spelke E. S., 1981, SOCIAL COGNITIVE DEV, P43
Tager-Flusberg H, 2007, PEDIATR CLIN N AM, V54, P469, DOI 10.1016/j.pcl.2007.02.011
Tager-Flusberg H, 2000, UNDERSTANDING LANGUA
Tordjman S, 2001, MOL PSYCHIATR, V6, P434, DOI 10.1038/sj.mp.4000873
Travis LL, 1998, MENT RETARD DEV D R, V4, P65, DOI 10.1002/(SICI)1098-2779(1998)4:2<65::AID-MRDD2>3.0.CO;2-W
Triebenbacher SL, 1998, PSYCHOL REP, V82, P191, DOI 10.2466/PR0.82.1.191-200
Turner DC, 2003, ANTHROZOOS, V16, P213
WING L, 1979, J AUTISM DEV DISORD, V9, P11, DOI 10.1007/BF01531288
Wong HHL, 2006, J AUTISM DEV DISORD, V36, P901, DOI 10.1007/s10803-006-0131-0
World Health Organization, 1994, COMP INT DIAGN INT V
NR 84
TC 9
Z9 9
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD AUG 1
PY 2012
VL 7
IS 8
AR e41739
DI 10.1371/journal.pone.0041739
PG 8
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 984SU
UT WOS:000307212800032
PM 22870246
ER
PT J
AU Sasson, NJ
Dichter, GS
Bodfish, JW
AF Sasson, Noah J.
Dichter, Gabriel S.
Bodfish, James W.
TI Affective Responses by Adults with Autism Are Reduced to Social Images
but Elevated to Images Related to Circumscribed Interests
SO PLOS ONE
LA English
DT Article
ID CONGENITAL ADRENAL-HYPERPLASIA; HIGH-FUNCTIONING AUTISM; SPECTRUM
DISORDERS; CIRCUMPLEX MODEL; YOUNG-CHILDREN; REPETITIVE BEHAVIOR; JOINT
ATTENTION; HIGH-IQ; GAZE; EMOTION
AB Individuals with autism spectrum disorders (ASD) demonstrate increased visual attention and elevated brain reward circuitry responses to images related to circumscribed interests (CI), suggesting that a heightened affective response to CI may underlie their disproportionate salience and reward value in ASD. To determine if individuals with ASD differ from typically developing (TD) adults in their subjective emotional experience of CI object images, non-CI object images and social images, 213 TD adults and 56 adults with ASD provided arousal ratings (sensation of being energized varying along a dimension from calm to excited) and valence ratings (emotionality varying along dimension of approach to withdrawal) for a series of 114 images derived from previous research on CI. The groups did not differ on arousal ratings for any image type, but ASD adults provided higher valence ratings than TD adults for CI-related images, and lower valence ratings for social images. Even after co-varying the effects of sex, the ASD group, but not the TD group, gave higher valence ratings to CI images than social images. These findings provide additional evidence that ASD is characterized by a preference for certain categories of non-social objects and a reduced preference for social stimuli, and support the dissemination of this image set for examining aspects of the circumscribed interest phenotype in ASD.
C1 [Sasson, Noah J.] Univ Texas Dallas, Sch Behav & Brain Sci, Richardson, TX 75083 USA.
[Dichter, Gabriel S.; Bodfish, James W.] Univ N Carolina, Sch Med, Carolina Inst Dev Disabil, Chapel Hill, NC USA.
RP Sasson, NJ (reprint author), Univ Texas Dallas, Sch Behav & Brain Sci, Richardson, TX 75083 USA.
EM nsasson@utdallas.edu
FU National Institute of Mental Health [2R01MH073402, K23 MH081285];
Participant Registry Core of the UNC Carolina Institute for
Developmental Disabilities [P30 HD03110]
FX This research was supported by National Institute of Mental Health
2R01MH073402 (Bodfish & Dichter), National Institute of Mental Health
K23 MH081285 (Dichter), and the Participant Registry Core of the UNC
Carolina Institute for Developmental Disabilities (P30 HD03110). The
funders had no role in study design, data collection and analysis,
decision to publish, or preparation of the manuscript.
CR Alexander GM, 2009, ARCH SEX BEHAV, V38, P427, DOI 10.1007/s10508-008-9430-1
American Psychiatric Association, 2000, DIAGN STAT MAN MENT
Anderson BA, 2011, P NATL ACAD SCI USA, V108, P10367, DOI 10.1073/pnas.1104047108
Attwood T, 2003, LEARNING AND BEHAVIOR PROBLEMS IN ASPERGER SYNDROME, P126
Attwood T., 1998, ASPERGERS SYNDROME G
Auyeung B, 2009, PSYCHOL SCI, V20, P144, DOI 10.1111/j.1467-9280.2009.02279.x
Bar-Haim Y, 2006, J AUTISM DEV DISORD, V36, P1
Baron-Cohen S, 2001, J AUTISM DEV DISORD, V31, P5, DOI 10.1023/A:1005653411471
Barrett LF, 2007, ANNU REV PSYCHOL, V58, P373, DOI 10.1146/annurev.psych.58.110405.085709
BARTAK L, 1976, J AUTISM CHILD SCHIZ, V6, P109, DOI 10.1007/BF01538054
Boyd BA, 2007, J AUTISM DEV DISORD, V37, P1550, DOI 10.1007/s10803-006-0286-8
BRADLEY MM, 1994, J BEHAV THER EXP PSY, V25, P49, DOI 10.1016/0005-7916(94)90063-9
Brooks R, 2005, DEVELOPMENTAL SCI, V8, P535, DOI 10.1111/j.1467-7687.2005.00445.x
Bryson SE, 2007, J AUTISM DEV DISORD, V37, P12, DOI 10.1007/s10803-006-0328-2
Centers for Disease Control and Prevention, 2012, MMWR WEEKL PREV AUT
Chawarska K, J CHILD PSY IN PRESS
Chawarska K, 2009, J AUTISM DEV DISORD, V39, P1663, DOI 10.1007/s10803-009-0803-7
Dalton KM, 2005, NAT NEUROSCI, V8, P519, DOI 10.1038/nn1421
Dawson G, 2005, DEV NEUROPSYCHOL, V27, P403, DOI 10.1207/s15326942dn2703_6
Dawson G, 2004, DEV PSYCHOL, V40, P271, DOI 10.1037/0012-1649.40.2.271
DeLoache JS, 2007, DEV PSYCHOL, V43, P1579, DOI 10.1037/0012-1649.43.6.1579
Dichter GS, 2012, J AUTISM DEV DISORD, V42, P147, DOI 10.1007/s10803-011-1221-1
Dichter GS, 2012, SOC COGN AFFECT NEUR, V7, P160, DOI 10.1093/scan/nsq095
Emery NJ, 2000, NEUROSCI BIOBEHAV R, V24, P581, DOI 10.1016/S0149-7634(00)00025-7
Farroni T, 2007, COGNITION, V102, P396, DOI 10.1016/j.cognition.2006.01.007
Fecteau S, 2003, AUTISM, V7, P255, DOI 10.1177/1362361303007003003
FREEMAN BJ, 1981, AM J PSYCHIAT, V138, P25
Gerber AJ, 2008, NEUROPSYCHOLOGIA, V46, P2129, DOI 10.1016/j.neuropsychologia.2008.02.032
Hines M., 2004, BRAIN GENDER
Ingudomnuku E, 2007, HORM BEHAV, V51, P597, DOI 10.1016/j.yhbeh.2007.02.001
Jadva V, 2010, ARCH SEX BEHAV, V39, P1261, DOI 10.1007/s10508-010-9618-z
JOHNSON MH, 1991, COGNITION, V40, P1, DOI 10.1016/0010-0277(91)90045-6
Johnson MH, 2000, BRAIN COGNITION, V42, P124, DOI 10.1006/brcg.1999.1180
Jones W, 2008, ARCH GEN PSYCHIAT, V65, P946, DOI 10.1001/archpsyc.65.8.946
Kanner L, 1943, NERV CHILD, V2, P217
Klin A, 2007, RES PRACT PERS SEV D, V32, P89
Klin A, 2002, AM J PSYCHIAT, V159, P895, DOI 10.1176/appi.ajp.159.6.895
Knickmeyer RC, 2008, J AUTISM DEV DISORD, V38, P1028, DOI 10.1007/s10803-007-0475-0
Knutson B, 2008, PHILOS T R SOC B, V363, P3771, DOI 10.1098/rstb.2008.0155
KOEGEL RL, 1974, J APPL BEHAV ANAL, V7, P521, DOI 10.1901/jaba.1974.7-521
Kringelbach ML, 2009, TRENDS COGN SCI, V13, P479, DOI 10.1016/j.tics.2009.08.006
Kylliainen A, 2006, J AUTISM DEV DISORD, V36, P517, DOI 10.1007/s10803-006-0091-4
Labar KS, 2007, CURR DIR PSYCHOL SCI, V16, P173, DOI 10.1111/j.1467-8721.2007.00498.x
Lam KSL, 2008, J CHILD PSYCHOL PSYC, V49, P1193, DOI 10.1111/j.1469-7610.2008.01944.x
LANG PJ, 1995, AM PSYCHOL, V50, P372, DOI 10.1037//0003-066X.50.5.372
LOVELAND KA, 1994, DEV PSYCHOPATHOL, V6, P433, DOI 10.1017/S0954579400006039
Mercier C., 2000, AUTISM, V4, P406, DOI 10.1177/1362361300004004006
Merin N, 2007, J AUTISM DEV DISORD, V37, P108, DOI 10.1007/s10803-006-0342-4
Meyer-Bahlburg HFL, 2004, ARCH SEX BEHAV, V33, P97, DOI 10.1023/B:ASEB.0000014324.25718.51
Nadig A, 2010, NEUROPSYCHOLOGIA, V48, P2730, DOI 10.1016/j.neuropsychologia.2010.05.020
Noland JS, 2010, DEVELOPMENTAL SCI, V13, P244, DOI 10.1111/j.1467-7687.2009.00882.x
Pasterski VL, 2005, CHILD DEV, V76, P264, DOI 10.1111/j.1467-8624.2005.00843.x
Peck CJ, 2009, J NEUROSCI, V29, P11182, DOI 10.1523/JNEUROSCI.1929-09.2009
Pierce K, 2011, ARCH GEN PSYCHIAT, V68, P101, DOI 10.1001/archgenpsychiatry.2010.113
Piven J, 1996, J AM ACAD CHILD PSY, V35, P523, DOI 10.1097/00004583-199604000-00019
Posner J, 2005, DEV PSYCHOPATHOL, V17, P715, DOI 10.1017/S0954579405050340
RUSSELL JA, 1980, J PERS SOC PSYCHOL, V39, P1161, DOI 10.1037/h0077714
Rutherford MD, 2008, J AUTISM DEV DISORD, V38, P1371, DOI 10.1007/s10803-007-0525-7
Sasson NJ, 2011, J AUTISM DEV DISORD, V41, P242, DOI 10.1007/s10803-010-1038-3
Sasson NJ, 2008, AUTISM RES, V1, P31, DOI 10.1002/aur.4
Sasson NJ, 2006, J AUTISM DEV DISORD, V36, P381, DOI 10.1007/s10803-006-0076-3
Schultz RT, 2005, INT J DEV NEUROSCI, V23, P125, DOI 10.1016/j.ijdevneu.2004.12.012
South M, 2005, J AUTISM DEV DISORD, V35, P145, DOI 10.1007/s10803-005-1992-3
Spezio M, 2006, NEUROPSYCHOLOGIA, V45, P144
Turner-Brown LM, 2011, AUTISM, V15, P437, DOI 10.1177/1362361310386507
VARNI JW, 1979, J ABNORM CHILD PSYCH, V7, P31, DOI 10.1007/BF00924508
Vismara LA, 2007, J POSIT BEHAV INTERV, V9, P214, DOI 10.1177/10983007070090040401
YIRMIYA N, 1989, J CHILD PSYCHOL PSYC, V30, P725, DOI 10.1111/j.1469-7610.1989.tb00785.x
NR 68
TC 3
Z9 3
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD AUG 1
PY 2012
VL 7
IS 8
AR e42457
DI 10.1371/journal.pone.0042457
PG 14
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 984SU
UT WOS:000307212800092
PM 22870328
ER
PT J
AU Barnes, JL
AF Barnes, Jennifer L.
TI Fiction, imagination, and social cognition: Insights from autism
SO POETICS
LA English
DT Article
DE Fiction; Theory of mind; Imagination; Autism
ID HIGH-FUNCTIONING AUTISM; NORMALLY DEVELOPING-CHILDREN;
ASPERGER-SYNDROME; SPECTRUM DISORDERS; WEAK COHERENCE; NORMAL ADULTS;
PRETEND PLAY; MIND; INDIVIDUALS; QUOTIENT
AB Some scholars have suggested that fiction builds upon our capacity for daydreaming and imagination, while others have proposed that it appeals to our capacity for getting inside the minds of others. However, very little research has investigated the way that individuals with deficits in imagination and social cognition view and develop preferences for fiction. Here, 1 review research on one such population: individuals with autism spectrum conditions (ASC) and present an experiment that investigates fiction preferences in ASC. As a whole, this work suggests that both fictionality and social content may play an important role in the appeal of fiction-and that the scientific study of fiction could benefit by taking into account the perspectives of individuals who view the world in different ways. (C) 2012 Elsevier B.V. All rights reserved.
C1 Univ Oklahoma, Dept Psychol, Norman, OK 73019 USA.
RP Barnes, JL (reprint author), Univ Oklahoma, Dept Psychol, 455 Lindsey St,Dale Hall Tower,Room 705, Norman, OK 73019 USA.
EM jennifer.barnes@aya.yale.edu
CR American Psychiatric Association [APA], 1994, DSM 4 DIAGN STAT MAN
Barnes J., 2011, J AUTISM DEV DISORDE
Barnes J., 2010, HDB PSYCHOLINGUISTIC, P731
Barnes JL, 2009, AUTISM RES, V2, P148, DOI 10.1002/aur.79
Baron-Cohen S., 1993, AUTISM
BARONCOHEN S, 1987, BRIT J DEV PSYCHOL, V5, P139
Baron-Cohen S, 2001, J AUTISM DEV DISORD, V31, P5, DOI 10.1023/A:1005653411471
BARONCOHEN S, 1992, BRIT J PSYCHIAT, V161, P839, DOI 10.1192/bjp.161.6.839
BARONCOHEN S, 1996, BRIT J PSYCHIAT, V168, P158, DOI DOI 10.1192/BJP.168.2.158
Baron-Cohen S, 1999, J AUTISM DEV DISORD, V29, P407, DOI 10.1023/A:1023035012436
Baron-Cohen S., 1998, AUTISM, V2, P296, DOI 10.1177/1362361398023008
Baron-Cohen S, 2004, J AUTISM DEV DISORD, V34, P163, DOI 10.1023/B:JADD.0000022607.19833.00
Baron-Cohen S., 1996, J COGNITIVE NEUROSCI, V8, P400
Baron-Cohen S, 2002, TRENDS COGN SCI, V6, P248, DOI 10.1016/S1364-6613(02)01904-6
Baron-Cohen S, 2001, J CHILD PSYCHOL PSYC, V42, P241, DOI 10.1017/S0021963001006643
Baron-Cohen S, 2006, PROG NEURO-PSYCHOPH, V30, P865, DOI 10.1016/j.pnpbp.2006.01.010
Baron-Cohen S., 1995, MINDBLINDESS
BaronCohen S, 1997, ISRAEL J PSYCHIAT, V34, P174
Bishop DVM, 2004, J CHILD PSYCHOL PSYC, V45, P1431, DOI 10.1111/j.1469-7610.2004.00325.x
Booth R, 2003, PHILOS T ROY SOC B, V358, P387, DOI 10.1098/rstb.2002.1204
Boraston ZL, 2008, J AUTISM DEV DISORD, V38, P574, DOI 10.1007/s10803-007-0421-1
Boyd B., 2009, ORIGIN STORIES EVOLU
Bruner J., 1993, UNDERSTANDING OTHER, P267
Carroll Joseph, 2004, LIT DARWINISM EVOLUT
Centers for Disease Control and Prevention, 2000, PREV AUT BRICK TOWNS
Charman T, 1997, DEV PSYCHOL, V33, P781, DOI 10.1037//0012-1649.33.5.781
Colle L, 2008, J AUTISM DEV DISORD, V38, P28, DOI 10.1007/s10803-007-0357-5
Craig J, 2000, ISRAEL J PSYCHIAT, V37, P64
Dutton D, 2004, PHILOS LITERATURE, V28, P453, DOI 10.1353/phl.2004.0024
Dziobek I, 2006, J AUTISM DEV DISORD, V36, P623, DOI 10.1007/s10803-006-0107-0
Fields S., 1979, SCREENPLAY FDN SCREE
Frith U., 1989, AUTISM EXPLAINING EN
Golan O, 2006, SOC NEUROSCI-UK, V1, P111, DOI 10.1080/17470910600980986
Goldman S, 2008, J AUTISM DEV DISORD, V38, P1982, DOI 10.1007/s10803-008-0588-0
Grandin T., 1995, THINKING PICTURES
Greco Albert N., 2005, BOOK PUBLISHING IND
Happe F, 2006, J AUTISM DEV DISORD, V36, P5, DOI 10.1007/s10803-005-0039-0
HAPPE FGE, 1994, J AUTISM DEV DISORD, V24, P129, DOI 10.1007/BF02172093
Hollander D., 2007, BIOL PSYCHIAT, V61, P498
Jarrold C, 2003, AUTISM, V7, P379, DOI 10.1177/1362361303007004004
Klin A, 2002, ARCH GEN PSYCHIAT, V59, P809, DOI 10.1001/archpsyc.59.9.809
Klin A, 2000, J CHILD PSYCHOL PSYC, V41, P831, DOI 10.1017/S0021963099006101
LESLIE AM, 1987, PSYCHOL REV, V94, P412, DOI 10.1037/0033-295X.94.4.412
Losh M, 2003, J AUTISM DEV DISORD, V33, P239, DOI 10.1023/A:1024446215446
Mar RA, 2006, J RES PERS, V40, P694, DOI 10.1016/j.jrp.2005.08.002
Mar RA, 2008, PERSPECT PSYCHOL SCI, V3, P173, DOI 10.1111/j.1745-6924.2008.00073.x
Nettle D., 2005, LIT ANIMAL EVOLUTION, P56
Norbury CF, 2003, INT J LANG COMM DIS, V38, P287, DOI 10.1080/136820310000108133
Norris M., 2010, BUSINESS CONSUMER BO
Oatley K, 2011, SUCH STUFF AS DREAMS: THE PSYCHOLOGY OF FICTION, P1, DOI 10.1002/9781119970910
OLIVER MB, 1993, HUM COMMUN RES, V19, P315, DOI 10.1111/j.1468-2958.1993.tb00304.x
OZONOFF S, 1991, J CHILD PSYCHOL PSYC, V32, P1107, DOI 10.1111/j.1469-7610.1991.tb00352.x
Ozonoff S, 1996, BRAIN LANG, V52, P411, DOI 10.1006/brln.1996.0022
Pinker Steven, 1997, MIND WORKS
Rutherford MD, 2002, J AUTISM DEV DISORD, V32, P189, DOI 10.1023/A:1015497629971
Scott FJ, 1999, BRIT J DEV PSYCHOL, V17, P349, DOI 10.1348/026151099165339
Sugiyama MS, 2001, EVOL HUM BEHAV, V22, P221
Surian L, 1996, Cogn Neuropsychiatry, V1, P55, DOI 10.1080/135468096396703
Tager-Flusberg H., 2000, UNDERSTANDING OTHER, P124
Tooby J, 2001, SUB-STANCE, P6
Walton K., 1993, PHILOS PHENOMENOLOGI, V51, P379
Young EC, 2005, LANG SPEECH HEAR SER, V36, P62, DOI 10.1044/0161-1461(2005/006)
Young S.M., 2009, HDB MANAGEMENT ACCOU, P1337
Zunshine L., 2006, WHY WE READ THEORY M
Zunshine L, 2011, SUB-STANCE, V40, P114
NR 65
TC 2
Z9 2
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0304-422X
EI 1872-7514
J9 POETICS
JI Poetics
PD AUG
PY 2012
VL 40
IS 4
BP 299
EP 316
DI 10.1016/j.poetic.2012.05.001
PG 18
WC Literature; Sociology
SC Literature; Sociology
GA 988ZI
UT WOS:000307529600001
ER
PT J
AU Belfquih, H
El Mostarchid, B
Akhaddar, A
Gazzaz, M
Boucetta, M
AF Belfquih, H.
El Mostarchid, B.
Akhaddar, A.
Gazzaz, M.
Boucetta, M.
TI Neuro-encephalic features of tuberous sclerosis complex
SO REVUE DE MEDECINE INTERNE
LA French
DT Article
DE Neuro-encephalic disorders; Cerebral magnetic resonance imaging;
Tuberous sclerosis
ID INFANTILE SPASMS; CONSENSUS CONFERENCE; DIAGNOSTIC-CRITERIA; CHILDREN;
EPILEPSY; SEIZURE; AUTISM
AB Tuberous sclerosis is a phacomatosis resulting from an autosomal dominant inheritance. It is characterized by the presence of multiple hamartomas in various organs, especially the brain, the skin, the kidneys and the heart. The diagnosis of tuberous sclerosis is based on imaging and clinical examination, where magnetic resonance imaging constitutes the key investigation showing characteristic brain lesions. Neuro-encephalic manifestations may be particularly severe, and may even be life threatening. The authors report personal cases series and review the literature highlighting epidemiology, clinical features and imaging of neuro-encephalic tuberous sclerosis. (C) 2012 Societe nationale francaise de medecine interne (SNFMI). Published by Elsevier Masson SAS. All rights reserved.
C1 [Belfquih, H.; El Mostarchid, B.; Akhaddar, A.; Gazzaz, M.; Boucetta, M.] Hop Mil Instruct Mohamed V, Serv Neurochirurg, Rabat, Morocco.
RP Belfquih, H (reprint author), Hop Mil Instruct Mohamed V, Serv Neurochirurg, Rabat, Morocco.
EM hothout_dr@hotmail.com
CR Adamsbaum C, 2005, J NEURORADIOLOGY, V32, P204, DOI 10.1016/S0150-9861(05)83138-4
Asano E, 2001, NEUROLOGY, V57, P1269
Au Kit-Sing, 2004, Journal of Child Neurology, V19, P699
BRAFFMAN BH, 1992, RADIOLOGY, V183, P227
Caron S, 2004, FEUILLETS RADIOLOGIE, V44, P241
Chateil JF, 2000, EMC PEDIAT, V22, P10
Chiron C, 1997, EPILEPSY RES, V26, P389, DOI 10.1016/S0920-1211(96)01006-6
Crino PB, 2006, NEW ENGL J MED, V355, P1345, DOI 10.1056/NEJMra055323
Curatolo Paolo, 2002, Eur J Paediatr Neurol, V6, P15, DOI 10.1053/ejpn.2001.0538
Curatolo P, 2008, LANCET, V372, P657, DOI 10.1016/S0140-6736(08)61279-9
El Kettani NEC, 2006, J RADIOL, V87, P109
Fleury P, 1980, Brain Dev, V2, P107
Goh S, 2004, NEUROLOGY, V63, P1457
Goh S, 2005, NEUROLOGY, V65, P235, DOI 10.1212/01.wnl.0000168908.78118.99
Gomez MR, 1995, BRAIN DEV-JPN, V17, P55, DOI 10.1016/0387-7604(94)00130-8
Goodman M, 1997, J CHILD NEUROL, V12, P85
Han JM, 2011, FEBS LETT, V585, P973, DOI 10.1016/j.febslet.2011.02.001
Hassan M, 1991, IMAGERIE RESONANCE M, P240
Husain AM, 2000, PEDIATR NEUROL, V23, P233, DOI 10.1016/S0887-8994(00)00186-7
Hyman MH, 2000, ARCH NEUROL-CHICAGO, V57, P662, DOI 10.1001/archneur.57.5.662
Jansen FE, 2004, J NEUROL NEUROSUR PS, V75, P770, DOI 10.1136/jnnp.2003.027524
Jeste SS, 2008, J CHILD NEUROL, V23, P520, DOI 10.1177/0883073807309788
Jozwiak S, 1998, INT J DERMATOL, V37, P911
Julien A, 2002, MED ET HYG DEVENIR, V22, P121
Julien A, 2001, NEUROPSYCHIAT ENFAN, V49, P124
Karenfort M, 2002, NEUROPEDIATRICS, V33, P255, DOI 10.1055/s-2002-36740
Nabbout R, 1999, J NEUROL NEUROSUR PS, V66, P370, DOI 10.1136/jnnp.66.3.370
O'Callaghan FJK, 2004, ARCH DIS CHILD, V89, P530, DOI 10.1136/adc.2003.026815
Prather P, 2004, J CHILD NEUROL, V19, P666
ROACH ES, 1992, J CHILD NEUROL, V7, P221
Roach ES, 1998, J CHILD NEUROL, V13, P624
Rosser Tena, 2006, Semin Pediatr Neurol, V13, P27, DOI 10.1016/j.spen.2006.01.008
Smirniotopoulos JG, 1999, RADIOGRAPHICS, V19, P205
Sparagana SP, 2003, ARCH NEUROL-CHICAGO, V60, P1286, DOI 10.1001/archneur.60.9.1286
Steven P, 2000, CURR OPIN NEUROL, V13, P115
Thiele EA, 2004, J CHILD NEUROL, V19, P680
Timotin L, 2005, REV MED INTERNE, V26, P511, DOI 10.1016/j.revmed.2005.01.007
Zaroff CM, 2006, SEIZURE-EUR J EPILEP, V15, P558, DOI 10.1016/j.seizure.2006.06.010
NR 38
TC 2
Z9 2
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI PARIS
PA 23 RUE LINOIS, 75724 PARIS, FRANCE
SN 0248-8663
J9 REV MED INTERNE
JI Rev. Med. Interne
PD AUG
PY 2012
VL 33
IS 8
BP 433
EP 438
DI 10.1016/j.revmed.2012.04.001
PG 6
WC Medicine, General & Internal
SC General & Internal Medicine
GA 983CC
UT WOS:000307092800004
PM 22658530
ER
PT J
AU Johnson, CR
Turner, KS
Foldes, EL
Malow, BA
Wiggs, L
AF Johnson, Cynthia R.
Turner, Kylan S.
Foldes, Emily L.
Malow, Beth A.
Wiggs, Luci
TI Comparison of sleep questionnaires in the assessment of sleep
disturbances in children with autism spectrum disorders
SO SLEEP MEDICINE
LA English
DT Article
DE Autism spectrum disorder; Sleep disturbance; Sleep disturbances; Sleep
questionnaires; Children's Sleep Habits Questionnaire; Modified Simonds
& Parraga Sleep; Questionnaire
ID PERVASIVE DEVELOPMENTAL DISORDERS; SEVERE LEARNING-DISABILITIES;
PSYCHOMETRIC PROPERTIES; HABITS QUESTIONNAIRE; BEHAVIORS; PATTERNS;
ADOLESCENTS; PREVALENCE
AB Background and purpose: The purpose of this study was to compare two parent completed questionnaires, the Modified Simonds & Parraga Sleep Questionnaire (MSPSQ) and the Children's Sleep Habits Questionnaire (CSHQ), used to characterize sleep disturbances in young children with autism spectrum disorders (ASD). Both questionnaires have been used in previous work in the assessment and treatment of children with ASD and sleep disturbance.
Participants and methods: Parents/caregivers of a sample of 124 children diagnosed with ASD with an average age of six years completed both sleep questionnaires regarding children's sleep behaviors. Internal consistency of the items for both measures was evaluated as well as the correlation between the two sleep measures. A Receiver Operating Characteristics (ROC) curve analysis was also conducted to examine the predictive power of the MSPSQ.
Results: More than three quarters of the sample (78%) were identified as poor sleepers on the CSHQ. Cronbach's alpha for the items on the CSHQ was 0.68 and Cronbach's alpha for items on the MSPSQ was 0.67. The total scores for MSPSQ and CSHQ were significantly correlated (r = .70, p < .01). After first identifying the poor sleepers based on the CSHQ, an area under the curve was 0.89 for the MSPSQ. Using a cut off score of 56 on the MSPSQ, sensitivity was .86 and specificity was .70.
Conclusions: In this sample of children with ASD, sleep disturbances were common across all cognitive levels. Preliminary findings suggest that, similar to the CSHQ, the MSPSQ has adequate internal consistency. The two measures were also highly correlated. A preliminary cut off of 56 on the MSPSQ offers high sensitivity and specificity commensurate with the widely used CSHQ. (C) 2012 Elsevier B.V. All rights reserved.
C1 [Johnson, Cynthia R.; Turner, Kylan S.; Foldes, Emily L.] Univ Pittsburgh, Sch Med, Pittsburgh, PA 15213 USA.
[Malow, Beth A.] Vanderbilt Univ, Dept Neurology, Sleep Disorders Div, Nashville, TN 37235 USA.
[Wiggs, Luci] Oxford Brookes Univ, Dept Psychol, Oxford OX3 0BP, England.
RP Johnson, CR (reprint author), Univ Pittsburgh, Childrens Hosp Pittsburgh, Sch Med, Autism Ctr, 3420 5th Ave, Pittsburgh, PA 15213 USA.
EM Cynthia.Johnson@chp.edu
FU National Institute of Mental Health [R34 MH082882-01A2]; Autism Speaks
(Autism Treatment Network); Autism Service, Education, a Research and
Training (ASERT) Grant from the Pennsylvania Bureau of Autism Services;
Department of Public Welfare; National Institute for Research Resources
[2ULRR024153-06]
FX This study was supported by funding from a National Institute of Mental
Health (R34 MH082882-01A2) award to the first author, Autism Speaks
(Autism Treatment Network), Autism Service, Education, a Research and
Training (ASERT) Grant from the Pennsylvania Bureau of Autism Services,
Department of Public Welfare, and the National Institute for Research
Resources (2ULRR024153-06).
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
Centers for Disease Control and Prevention, 2008, AUT INF CTR FREQ ASK
Couturier JL, 2005, J AM ACAD CHILD PSY, V44, P815, DOI 10.1097/01.chi.0000166377.22651.87
Goodlin-Jones BL, 2008, J DEV BEHAV PEDIATR, V29, P82, DOI 10.1097/DBP.0b013e318163c39a
Honomichl RD, 2002, J AUTISM DEV DISORD, V32, P553, DOI 10.1023/A:1021254914276
Johnson CR, 1996, CHILD ADOL PSYCH CL, V5, P673
Krakowiak P, 2008, J SLEEP RES, V17, P197, DOI 10.1111/j.1365-2869.2008.00650.x
Liu XC, 2006, CHILD PSYCHIAT HUM D, V37, P179, DOI 10.1007/s10578-006-0028-3
Lord C., 2002, AUTISM DIAGNOSTIC OB
Maas APHM, 2011, RES DEV DISABIL, V32, P2467, DOI 10.1016/j.ridd.2011.07.013
Malow BA, 2006, SLEEP, V29, P1563
Miano S, 2007, SLEEP MED, V9, P64, DOI 10.1016/j.sleep.2007.01.014
Mullen E, 1995, MULLEN SCALES EARLY
Owens JA, 2000, SLEEP, V23, P1043
Polimeni MA, 2005, J INTELL DISABIL RES, V49, P260, DOI 10.1111/j.1365-2788.2005.00642.x
RICHDALE AL, 1995, EUR CHILD ADOLES PSY, V4, P175
Robinson AM, 2004, CHILD CARE HLTH DEV, V30, P139, DOI 10.1111/j.1365-2214.2004.00395.x
Roid G. H., 2003, STANFORD BINET INTEL
Schreck KA, 2011, J SLEEP RES, V20, P589, DOI 10.1111/j.1365-2869.2011.00922.x
Schreck KA, 2000, J AUTISM DEV DISORD, V30, P127, DOI 10.1023/A:1005407622050
SIMONDS JF, 1984, J DEV BEHAV PEDIATR, V5, P6
SIMONDS JF, 1982, J AM ACAD CHILD PSY, V21, P383, DOI 10.1016/S0002-7138(09)60942-0
Souders MC, 2009, SLEEP, V32, P1566
Spruyt K, 2011, SLEEP MED REV, V15, P7, DOI 10.1016/j.smrv.2010.06.003
Spruyt K, 2011, SLEEP MED REV, V15, P19, DOI 10.1016/j.smrv.2010.07.005
SPSS Inc, 2010, STAT PACK SOC SCI PA
Stores R, 1998, J APPL RES INTELLECT, V11, P345
Wiggs L, 1998, J SLEEP RES, V7, P119, DOI 10.1046/j.1365-2869.1998.00107.x
Wiggs L, 2004, DEV MED CHILD NEUROL, V46, P372
Wiggs L, 1996, J INTELL DISABIL RES, V40, P518, DOI 10.1046/j.1365-2788.1996.799799.x
NR 30
TC 5
Z9 5
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1389-9457
J9 SLEEP MED
JI Sleep Med.
PD AUG
PY 2012
VL 13
IS 7
BP 795
EP 801
DI 10.1016/j.sleep.2012.03.005
PG 7
WC Clinical Neurology
SC Neurosciences & Neurology
GA 992AL
UT WOS:000307747000005
PM 22609024
ER
PT J
AU Waite, A
Brown, SC
Blake, DJ
AF Waite, Adrian
Brown, Susan C.
Blake, Derek J.
TI The dystrophin-glycoprotein complex in brain development and disease
SO TRENDS IN NEUROSCIENCES
LA English
DT Review
DE muscular dystrophy; dystrophin; dystroglycan; cognitive impairment;
neuronal migration; dystonia
ID DUCHENNE MUSCULAR-DYSTROPHY; FUKUTIN-RELATED PROTEIN; MYOCLONUS-DYSTONIA
SYNDROME; DEFICIENT MDX MICE; CEREBELLAR PURKINJE-CELLS; AUTISM SPECTRUM
DISORDER; CENTRAL-NERVOUS-SYSTEM; EPSILON-SARCOGLYCAN; INHIBITORY
SYNAPSES; MENTAL-RETARDATION
AB In addition to muscle disease, defects in processing and assembly of the dystrophin-glycoprotein complex (DGC) are associated with a spectrum of brain abnormalities ranging from mild cognitive impairment (MCI) to neuronal migration disorders. In brain, the DGC is involved in the organisation of GABA(A) receptors (GABA(A)Rs) and aquaporin-4 (AQP4)-containing protein complexes in neurons and glia, respectively. During development, defects in the glycosylation of alpha-dystroglycan that impair its ability to interact with the extracellular matrix (ECM) are frequently associated with cobblestone lissencephaly and mental retardation. Furthermore, mutations in the gene encoding epsilon-sarcoglycan (SGCE) cause the neurogenic movement disorder myoclonus dystonia syndrome. In this review, we describe recent progress in defining distinct roles for the DGC in neurons and glia.
C1 [Waite, Adrian; Blake, Derek J.] Cardiff Univ, Inst Psychol Med & Clin Neurosci, MRC Ctr Neuropsychiat Genet & Genom, Cardiff CF14 4XN, S Glam, Wales.
[Brown, Susan C.] Univ London Royal Vet Coll, London NW1 0TU, England.
RP Blake, DJ (reprint author), Cardiff Univ, Inst Psychol Med & Clin Neurosci, MRC Ctr Neuropsychiat Genet & Genom, Heath Pk, Cardiff CF14 4XN, S Glam, Wales.
EM blakedj@cardiff.ac.uk
FU Medical Research Council
FX Because of space constraints it has regrettably not been possible to
cite all of the primary literature in this review. The work was
generously supported by a studentship from the Medical Research Council
(to A.W.). We thank Dr Mark Ackroyd for providing the images used in
Figure 3b,c.
CR Ackroyd MR, 2009, BRAIN, V132, P439, DOI 10.1093/brain/awn335
Ackroyd MR, 2011, J NEUROSCI, V31, P12927, DOI 10.1523/JNEUROSCI.2301-11.2011
Akasaka-Manya K, 2006, J BIOL CHEM, V281, P19339, DOI 10.1074/jbc.M601091200
Allikian MJ, 2007, TRAFFIC, V8, P177, DOI 10.1111/j.1600-0854.2006.00519.x
Amiry-Moghaddam M, 2003, P NATL ACAD SCI USA, V100, P2106, DOI 10.1073/pnas.0437946100
Anderson JL, 2004, BRAIN RES, V1019, P289, DOI 10.1016/j.brainres.2004.06.011
Anderson JL, 2003, BRAIN RES, V982, P280, DOI 10.1016/S0006-8993(03)03018-X
Barresi R, 2004, NAT MED, V10, P696, DOI 10.1038/nm1059
Beukers RJ, 2009, EUR J NUCL MED MOL I, V36, P269, DOI 10.1007/s00259-008-0924-9
Billard C, 1998, DEV MED CHILD NEUROL, V40, P12
Blake DJ, 1999, J CELL BIOL, V147, P645, DOI 10.1083/jcb.147.3.645
Blake DJ, 1998, P NATL ACAD SCI USA, V95, P241, DOI 10.1073/pnas.95.1.241
Blake Derek J., 1992, Human Molecular Genetics, V1, P103, DOI 10.1093/hmg/1.2.103
Blake DJ, 2000, TRENDS NEUROSCI, V23, P92, DOI 10.1016/S0166-2236(99)01510-6
Blake DJ, 2002, PHYSIOL REV, V82, P291, DOI 10.1152/physrev.00028.2001
Bozzi M, 2009, MATRIX BIOL, V28, P179, DOI 10.1016/j.matbio.2009.03.003
Breakefield XO, 2008, NAT REV NEUROSCI, V9, P222, DOI 10.1038/nrn2337
BRESOLIN N, 1994, NEUROMUSCULAR DISORD, V4, P359, DOI 10.1016/0960-8966(94)90072-8
Brockington M, 2001, AM J HUM GENET, V69, P1198, DOI 10.1086/324412
Brunig I, 2002, J NEUROSCI, V22, P4805
BUSHBY KMD, 1995, DEV MED CHILD NEUROL, V37, P260
BYERS TJ, 1993, NAT GENET, V4, P77, DOI 10.1038/ng0593-77
Carretta D, 2004, BRAIN RES, V1016, P1, DOI 10.1016/j.brainres.2004.04.021
Carretta D, 2003, J COMP NEUROL, V456, P48, DOI 10.1002/cne.10506
Chan P, 2005, J COMP NEUROL, V482, P50, DOI 10.1002/cne.20377
Chan YM, 2010, HUM MOL GENET, V19, P3995, DOI 10.1093/hmg/ddq314
Cotton SM, 2005, DEV MED CHILD NEUROL, V47, P257, DOI 10.1017/S0012162205000496
Daoud F, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0006574
Daoud F, 2009, HUM MOL GENET, V18, P3779, DOI 10.1093/hmg/ddp320
Davies KE, 2006, NAT REV MOL CELL BIO, V7, P762, DOI 10.1038/nrm2024
Desguerre I, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0004347
DSOUZA VN, 1995, HUM MOL GENET, V4, P837, DOI 10.1093/hmg/4.5.837
Duchenne G.B.A, 1868, ARCH GEN MED, V11, P179
Duchenne G.B.A, 1868, ARCH GEN MED, V11, P305
Duchenne GBA, 1868, ARCH GEN MED, V11, P5
Duchenne G.B.A, 1868, ARCH GEN MED, V11, p[421, 421]
Duchenne G.B.A, 1868, ARCH GEN MED, V11, P552
ERVASTI JM, 1991, CELL, V66, P1121, DOI 10.1016/0092-8674(91)90035-W
Ervasti JM, 2007, BBA-MOL BASIS DIS, V1772, P108, DOI 10.1016/j.bbadis.2006.05.010
Esapa CT, 2007, HUM MOL GENET, V16, P327, DOI 10.1093/hmg/ddl472
FEENER CA, 1989, NATURE, V338, P509, DOI 10.1038/338509a0
Fritschy J.M., 2012, CELL MOL LIFE SCI
Fritschy JM, 2008, TRENDS NEUROSCI, V31, P257, DOI 10.1016/j.tins.2008.02.006
Fukaya M, 2011, J NEUROCHEM, V116, P1122, DOI 10.1111/j.1471-4159.2010.07167.x
Gai X, 2012, MOL PSYCHIATR, V17, P402, DOI 10.1038/mp.2011.10
Godfrey C, 2011, CURR OPIN GENET DEV, V21, P278, DOI 10.1016/j.gde.2011.02.001
Godfrey C, 2007, BRAIN, V130, P2725, DOI 10.1093/brain/awm212
Grady RM, 2006, J NEUROSCI, V26, P2841, DOI 10.1523/JNEUROSCI.4823-05.2006
Graf ER, 2004, CELL, V119, P1013, DOI 10.1016/j.cell.2004.11.035
Haenggi T, 2006, CELL MOL LIFE SCI, V63, P1614, DOI 10.1007/s00018-005-5461-0
Haenggi T, 2004, NEUROSCIENCE, V129, P403, DOI 10.1016/j.neuroscience.2004.06.079
Hara Y, 2011, NEW ENGL J MED, V364, P939, DOI 10.1056/NEJMoa1006939
Hendriksen JGM, 2008, J CHILD NEUROL, V23, P477, DOI 10.1177/0883073807309775
Hinton VJ, 2000, NEUROLOGY, V54, P2127
Hjermind LE, 2008, EUR J NEUROL, V15, P525, DOI 10.1111/j.1468-1331.2008.02116.x
Hu HY, 2011, J COMP NEUROL, V519, P1320, DOI 10.1002/cne.22572
Huang X, 2000, NAT STRUCT BIOL, V7, P634, DOI 10.1038/77923
Inamori K, 2012, SCIENCE, V335, P93, DOI 10.1126/science.1214115
JAGADHA V, 1988, PEDIATR NEUROL, V4, P87, DOI 10.1016/0887-8994(88)90047-1
Jarius S, 2010, NAT REV NEUROL, V6, P383, DOI 10.1038/nrneurol.2010.72
Kerjan G, 2007, TRENDS GENET, V23, P623, DOI 10.1016/j.tig.2007.09.003
Knuesel I, 1999, EUR J NEUROSCI, V11, P4457, DOI 10.1046/j.1460-9568.1999.00887.x
Kobayashi K, 1998, NATURE, V394, P388
Kueh SLL, 2008, CLIN EXP PHARMACOL P, V35, P207, DOI 10.1111/j.1440-1681.2007.04816.x
Kueh SLL, 2011, NEUROBIOL DIS, V43, P558, DOI 10.1016/j.nbd.2011.05.002
Kurahashi H, 2005, NEUROBIOL DIS, V19, P208, DOI 10.1016/j.nbd.2004.12.018
Lee JS, 2002, MUSCLE NERVE, V26, P506, DOI 10.1002/mus.10238
Levi S, 2002, J NEUROSCI, V22, P4274
LIDOV HGW, 1995, HUM MOL GENET, V4, P329, DOI 10.1093/hmg/4.3.329
LIDOV HGW, 1990, NATURE, V348, P725, DOI 10.1038/348725a0
Liu JM, 2006, MECH DEVELOP, V123, P228, DOI 10.1016/j.mod.2005.12.003
Luscher B, 2011, NEURON, V70, P385, DOI 10.1016/j.neuron.2011.03.024
Lv SY, 2011, AM J NEURORADIOL, V32, P2196, DOI 10.3174/ajnr.A2718
Masaki T, 2010, J BIOMED BIOTECHNOL, DOI 10.1155/2010/740403
McNally EM, 2007, ANNU REV PATHOL-MECH, V2, P87, DOI 10.1146/annurev.pathol.2.010506.091936
Mehler MF, 2000, BRAIN RES REV, V32, P277, DOI 10.1016/S0165-0173(99)00090-9
Minciacchi D, 2010, NEUROSCIENCE, V166, P1129, DOI 10.1016/j.neuroscience.2010.01.040
Miranda R, 2009, CEREB CORTEX, V19, P876, DOI 10.1093/cercor/bhn135
Moore CJ, 2010, CELL COMMUN SIGNAL, V8, DOI 10.1186/1478-811X-8-3
Muntoni F, 2007, Acta Myol, V26, P129
Nicchia GP, 2008, GLIA, V56, P869, DOI 10.1002/glia.20661
Nishiyama A, 2004, MOL BRAIN RES, V125, P1, DOI 10.1016/j.molbraines.2004.01.012
Noell S, 2011, EUR J NEUROSCI, V33, P2179, DOI 10.1111/j.1460-9568.2011.07688.x
Ozawa E, 2005, MUSCLE NERVE, V32, P563, DOI 10.1002/mus.20349
Panzanelli P, 2011, J PHYSIOL-LONDON, V589, P4959, DOI 10.1113/jphysiol.2011.216028
Pawlisz AS, 2011, PLOS BIOL, V9, DOI 10.1371/journal.pbio.1001172
Peall KJ, 2011, MOVEMENT DISORD, V26, P1939, DOI 10.1002/mds.23791
Perronnet C, 2010, J BIOMED BIOTECHNOL, DOI 10.1155/2010/849426
Phukan J, 2011, LANCET NEUROL, V10, P1074, DOI 10.1016/S1474-4422(11)70232-0
Piluso G, 2000, J BIOL CHEM, V275, P15851, DOI 10.1074/jbc.M000439200
Poulopoulos A, 2009, NEURON, V63, P628, DOI 10.1016/j.neuron.2009.08.023
Sandona D, 2009, EXPERT REV MOL MED, V11, DOI 10.1017/S1462399409001203
Satz JS, 2010, J NEUROSCI, V30, P14560, DOI 10.1523/JNEUROSCI.3247-10.2010
SBRICCOLI A, 1995, NEUROSCI LETT, V200, P53, DOI 10.1016/0304-3940(95)12079-J
Sesay AK, 1996, NEUROSCI LETT, V211, P207, DOI 10.1016/0304-3940(96)12747-6
Sugita S, 2001, J CELL BIOL, V154, P435, DOI 10.1083/jcb.200105003
Sumita K, 2007, J NEUROCHEM, V100, P154, DOI 10.1111/j.1471-4159.2006.04170.x
Tadayoni R, 2012, MOL NEUROBIOL, V45, P43, DOI 10.1007/s12035-011-8218-9
Taylor PJ, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0008803
Tian M, 1996, EUR J NEUROSCI, V8, P2739, DOI 10.1111/j.1460-9568.1996.tb01568.x
Topaloglu H, 2003, NEUROLOGY, V60, P988
Tozawa T, 2012, MOL NEUROBIOL, V45, P287, DOI 10.1007/s12035-012-8233-5
TRACEY I, 1995, LANCET, V345, P1260, DOI 10.1016/S0140-6736(95)90923-0
Vaillend C, 2008, BEHAV BRAIN RES, V192, P88, DOI 10.1016/j.bbr.2008.01.009
Vaillend C, 2010, MOL THER, V18, P1683, DOI 10.1038/mt.2010.134
Vaillend C, 2004, NEUROBIOL DIS, V17, P10, DOI 10.1016/j.nbd.2004.05.004
Vaillend C, 1999, NEUROMUSCULAR DISORD, V9, P296, DOI 10.1016/S0960-8966(99)00029-2
VAILLEND C, 1995, BEHAV GENET, V25, P569, DOI 10.1007/BF02327580
Vajda Z, 2002, P NATL ACAD SCI USA, V99, P13131, DOI 10.1073/pnas.192457099
Waite A, 2011, HUM MUTAT, V32, P1246, DOI 10.1002/humu.21561
Waite A, 2009, ANN MED, V41, P344, DOI 10.1080/07853890802668522
Wallace GQ, 2009, ANNU REV PHYSIOL, V71, P37, DOI 10.1146/annurev.physiol.010908.163216
Willer T, 2004, P NATL ACAD SCI USA, V101, P14126, DOI 10.1073/pnas.0405899101
Williamson RA, 1997, HUM MOL GENET, V6, P831, DOI 10.1093/hmg/6.6.831
Wu JY, 2005, J CHILD NEUROL, V20, P790, DOI 10.1177/08830738050200100201
Yokoi F, 2006, J BIOCHEM, V140, P141, DOI 10.1093/jb/mvj138
Yoshida A, 2001, DEV CELL, V1, P717, DOI 10.1016/S1534-5807(01)00070-3
Yoshida-Moriguchi T, 2010, SCIENCE, V327, P88, DOI 10.1126/science.1180512
Zimprich A, 2001, NAT GENET, V29, P66, DOI 10.1038/ng709
NR 119
TC 25
Z9 26
PU ELSEVIER SCIENCE LONDON
PI LONDON
PA 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND
SN 0166-2236
J9 TRENDS NEUROSCI
JI Trends Neurosci.
PD AUG
PY 2012
VL 35
IS 8
BP 487
EP 496
DI 10.1016/j.tins.2012.04.004
PG 10
WC Neurosciences
SC Neurosciences & Neurology
GA 990HW
UT WOS:000307622600004
PM 22626542
ER
PT J
AU Karvat, G
Kimchi, T
AF Karvat, Golan
Kimchi, Tali
TI Systematic autistic-like behavioral phenotyping of 4 mouse strains using
a novel wheel-running assay
SO BEHAVIOURAL BRAIN RESEARCH
LA English
DT Article
DE Autism; BTBR; Nlgn3; Sociability; Cognitive rigidity; Running wheel
ID T PLUS TF/J; DEFICIT HYPERACTIVITY DISORDER; BTBR-T+TF/J MICE; INBRED
STRAINS; C57BL/6J MICE; SOCIAL-BEHAVIOR; ACETYLCHOLINE OUTPUT; SPECTRUM
DISORDERS; FOOD-DEPRIVATION; TASKS RELEVANT
AB Three core symptoms of autistic spectrum disorders are stereotypic movements, resistance to change in routines and deficits in social interaction. In order to understand their neuronal mechanisms, there is a dire need for behavioral paradigms to assess those symptoms in rodents. Here we present a novel method which is based on positive reward in a customized wheel-running apparatus to assess these symptoms. As a proof of concept, 4 mouse strains were tested in the new behavioral paradigm; 2 control lines (C57BL/6 and ICR) and 2 mouse-models of autism (BTBR T+ tf/J and Nlgn3(tm1sud)) We found that the C57BL/6. ICR and Nlgn3(tm1sud) mice showed a significant reduction in stereotypical behavior in the presence of the running wheel, ability to forfeit the running habit when the running-wheel was jammed, and preference of interacting with a social stimulus over the jammed running-wheel. No difference was found between genotypes of the Nlgn3(tm1sud) mice. On the other hand, the BTBR mice exhibited persistent, elevated levels of stereotypical behavior. In addition, they presented a deficit in their ability to adjust to a changing environment, as manifested in persistence to interact with the wheel even when it was jammed. Lastly, the BTBR mice exhibited no significant preference to interact with the stranger mouse over the jammed running-wheel. These results were validated by a set of commonly used behavioral tests. Overall, our novel behavioral paradigm detects multiple components of autistic-like phenotypes, including cognitive rigidity, stereotypic behavior and social deficiency. (C) 2012 Elsevier B.V. All rights reserved.
C1 [Karvat, Golan; Kimchi, Tali] Weizmann Inst Sci, Dept Neurobiol, IL-76100 Rehovot, Israel.
RP Kimchi, T (reprint author), Weizmann Inst Sci, Dept Neurobiol, IL-76100 Rehovot, Israel.
EM Golan.karvat@weizmann.ac.il; tali.kimchi@weizmann.ac.il
CR Amodeo DA, 2012, BEHAV BRAIN RES, V227, P64, DOI 10.1016/j.bbr.2011.10.032
(APA) APA, 2000, DIAGN STAT MAN MENT
Arakawa H, 2008, BEHAV BRAIN RES, V190, P97, DOI 10.1016/j.bbr.2008.02.009
Bartal IBA, 2011, SCIENCE, V334, P1427, DOI 10.1126/science.1210789
BAUMAN RA, 1992, PHYSIOL BEHAV, V52, P1077, DOI 10.1016/0031-9384(92)90462-B
Blanchard DC, 2012, NEUROSCI BIOBEHAV R, V36, P285, DOI 10.1016/j.neubiorev.2011.06.008
Bolivar VJ, 2007, BEHAV BRAIN RES, V176, P21, DOI 10.1016/j.bbr.2006.09.007
BRANT DH, 1965, ECOLOGY, V46, P452, DOI 10.2307/1934876
Brown HD, 2010, J NEUROSCI, V30, P14390, DOI 10.1523/JNEUROSCI.2167-10.2010
Budreck EC, 2007, EUR J NEUROSCI, V26, P1738, DOI 10.1111/j.1460-9568.2007.05842.x
Cantallops I, 2000, CURR BIOL, V10, pR620, DOI 10.1016/S0960-9822(00)00663-1
Chadman KK, 2011, PHARMACOL BIOCHEM BE, V97, P586, DOI 10.1016/j.pbb.2010.09.012
Chadman KK, 2008, AUTISM RES, V1, P147, DOI 10.1002/aur.22
Chudasama Y, 2003, J NEUROSCI, V23, P8771
Crawley JN, 2007, BRAIN PATHOL, V17, P448, DOI 10.1111/j.1750-3639.2007.00096.x
Crawley JN, 2004, MENT RETARD DEV D R, V10, P248, DOI 10.1002/mrdd.20039
Deacon RMJ, 2009, NEUROMETHODS, V42, P37, DOI 10.1007/978-1-60761-303-9_3
EIKELBOOM R, 1988, PHYSIOL BEHAV, V43, P625, DOI 10.1016/0031-9384(88)90217-X
Etherton M, 2011, P NATL ACAD SCI USA, V108, P13764, DOI 10.1073/pnas.1111093108
Ey E, 2011, AUTISM RES, V4, P5, DOI 10.1002/aur.175
File SE, 2003, EUR J PHARMACOL, V463, P35, DOI 10.1016/S0014-2999(03)01273-1
Floresco SB, 2006, NEUROPSYCHOPHARMACOL, V31, P297, DOI 10.1038/sj.npp.1300825
GERALL AA, 1973, PHYSIOL BEHAV, V10, P225, DOI 10.1016/0031-9384(73)90302-8
Guariglia SR, 2011, NEUROTOXICOLOGY, V32, P545, DOI 10.1016/j.neuro.2011.06.008
Guidotti A, 2001, BRAIN RES REV, V37, P110, DOI 10.1016/S0165-0173(01)00129-1
Hallmayer J, 2011, ARCH GEN PSYCHIAT, V68, P1095, DOI 10.1001/archgenpsychiatry.2011.76
Harri M, 1999, LAB ANIM SCI, V49, P401
Herbert MR, 2006, NEUROTOXICOLOGY, V27, P671, DOI 10.1016/j.neuro.2006.03.017
Howerton CL, 2008, APPL ANIM BEHAV SCI, V115, P90, DOI 10.1016/j.applanim.2008.05.004
Hunsberger J, 2007, PROTOCOL EXCHANGE
Institute of Laboratory Animal R, 1996, GUID CAR US LAB AN
JAKUBCZA.LF, 1973, ANIM LEARN BEHAV, V1, P13, DOI 10.3758/BF03198990
Jamain S, 2003, NAT GENET, V34, P27, DOI 10.1038/ng1136
Kalueff AV, 2004, BRAIN RES, V1028, P75, DOI 10.1016/j.brainres.2004.09.001
Kalueff AV, 2004, BRAIN RES PROTOC, V13, P151, DOI 10.1016/j.brainresprot.2004.04.002
KANNER L, 1968, ACTA PAEDOPSYCHIATR, V35, P100
KAVANAU J. LEE, 1963, BEHAVIOUR, V20, P251
Kock LL, 1971, Z TIERPSYCHOL, V29, P180
LEANDER JD, 1973, J EXP ANAL BEHAV, V19, P17, DOI 10.1901/jeab.1973.19-17
Lewis MH, 2007, BEHAV BRAIN RES, V176, P66, DOI 10.1016/j.bbr.2006.08.023
Lister R. G., 1987, PSYCHOPHARMACOLOGY, V92
LOOY H, 1989, PHYSIOL BEHAV, V45, P403, DOI 10.1016/0031-9384(89)90147-9
Lucey JV, 1997, BRIT J MED PSYCHOL, V70, P403
MASON GJ, 1991, ANIM BEHAV, V41, P1015, DOI 10.1016/S0003-3472(05)80640-2
McCool MF, 2008, NEUROBIOL LEARN MEM, V89, P114, DOI 10.1016/j.nlm.2007.06.005
McFarlane HG, 2008, GENES BRAIN BEHAV, V7, P152, DOI 10.1111/j.1601-183X.2007.00330.x
MELCER T, 1986, BEHAV PROCESS, V13, P29, DOI 10.1016/0376-6357(86)90014-8
MORAN G, 1975, PSYCHOL BULL, V82, P543, DOI 10.1037/h0076799
MORRIS R, 1984, J NEUROSCI METH, V11, P47, DOI 10.1016/0165-0270(84)90007-4
MORRIS RGM, 1982, NATURE, V297, P681, DOI 10.1038/297681a0
Moy SS, 2007, BEHAV BRAIN RES, V176, P4, DOI 10.1016/j.bbr.2006.07.030
Moy SS, 2008, BEHAV BRAIN RES, V188, P178, DOI 10.1016/j.bbr.2007.10.029
Moy SS, 2004, GENES BRAIN BEHAV, V3, P287, DOI 10.1111/j.1601-183X.2004.00076.x
Moy SS, 2007, MOL PSYCHIATR, V13, P4, DOI 10.1038/sj.mp.4002082
Nestler EJ, 2010, NAT NEUROSCI, V13, P1161, DOI 10.1038/nn.2647
Pantelis C, 1999, SCHIZOPHR RES, V37, P251, DOI 10.1016/S0920-9964(98)00156-X
Pawlowicz A, 2010, BEHAV PROCESS, V83, P242, DOI 10.1016/j.beproc.2009.11.008
Pearson BL, 2011, GENES BRAIN BEHAV, V10, P228, DOI 10.1111/j.1601-183X.2010.00659.x
Pearson BL, 2010, BEHAV BRAIN RES, V213, P189, DOI 10.1016/j.bbr.2010.04.054
Pearson DA, 2006, CHILD NEUROPSYCHOL, V12, P321, DOI 10.1080/092970406006464847
Philibert RA, 2000, GENE, V246, P303, DOI 10.1016/S0378-1119(00)00049-4
Pinto D, 2010, NATURE, V466, P368, DOI 10.1038/nature09146
Pobbe RLH, 2010, BEHAV BRAIN RES, V214, P443, DOI 10.1016/j.bbr.2010.06.025
Pobbe RLH, 2011, BEHAV BRAIN RES, V216, P446, DOI 10.1016/j.bbr.2010.08.039
PORSOLT RD, 1977, ARCH INT PHARMACOD T, V229, P327
PREMACK D, 1963, J EXP ANAL BEHAV, V6, P473, DOI 10.1901/jeab.1963.6-473
Radyushkin K, 2009, GENES BRAIN BEHAV, V8, P416, DOI 10.1111/j.1601-183X.2009.00487.x
Ragozzino ME, 2004, LEARN MEMORY, V11, P70, DOI 10.1101/lm.65404
Reeve WV, 2001, ADOLESCENCE, V36, P749
Ricceri L, 2007, BEHAV BRAIN RES, V176, P40, DOI 10.1016/j.bbr.2006.08.024
Rosenberg RE, 2009, ARCH PEDIAT ADOL MED, V163, P907, DOI 10.1001/archpediatrics.2009.98
Roullet FI, 2010, BEHAV BRAIN RES, V216, P19, DOI [10.1016/j.bbr.2010.06.004, DOI 10.1016/J.BBR.2010.06.004]
Sanchez C, 1997, EUR NEUROPSYCHOPHARM, V7, P283, DOI 10.1016/S0924-977X(97)00035-7
Scattoni ML, 2008, PLOS ONE, V3, DOI 10.1371/journal.pone.0003067
Sherwin CM, 1998, ANIM BEHAV, V56, P11, DOI 10.1006/anbe.1998.0836
Silverman JL, 2010, NAT REV NEUROSCI, V11, P490, DOI 10.1038/nrn2851
Tabuchi K, 2007, SCIENCE, V318, P71, DOI 10.1126/science.1146221
TEPPER JS, 1986, J APPL PHYSIOL, V60, P868
TERRANOVA ML, 1993, DEV PSYCHOBIOL, V26, P467, DOI 10.1002/dev.420260805
Tsuchida A, 2010, J NEUROSCI, V30, P16868, DOI 10.1523/JNEUROSCI.1958-10.2010
UPCHURCH M, 1988, BEHAV GENET, V18, P55, DOI 10.1007/BF01067075
Verplanken B., 1999, EUROPEAN REV SOCIAL, V10, P101, DOI DOI 10.1080/14792779943000035
Volkmar F, 2005, ANNU REV PSYCHOL, V56, P315, DOI 10.1146/annurev.psych.56.091103.070159
VonDras DD, 2005, AGING MENT HEALTH, V9, P60, DOI 10.1080/13607860412331323782
WALKER CD, 1995, J NEUROENDOCRINOL, V7, P615, DOI 10.1111/j.1365-2826.1995.tb00799.x
LAWSON REED, 1963, OHIO JOUR SCI, V63, P87
Yang M, 2011, AUTISM RES, V4, P17, DOI 10.1002/aur.163
Yang M, 2007, INT J DEV NEUROSCI, V25, P515, DOI 10.1016/j.ijdevneu.2007.09.008
Yang PC, 2004, PSYCHIAT CLIN NEUROS, V58, P37, DOI 10.1111/j.1440-1819.2004.01190.x
Yintian Y, 2007, J CHENGDU SPORT U, V5
Zagreda L, 1999, J NEUROSCI, V19, P6175
NR 91
TC 6
Z9 6
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0166-4328
J9 BEHAV BRAIN RES
JI Behav. Brain Res.
PD AUG 1
PY 2012
VL 233
IS 2
BP 405
EP 414
DI 10.1016/j.bbr.2012.05.028
PG 10
WC Behavioral Sciences; Neurosciences
SC Behavioral Sciences; Neurosciences & Neurology
GA 986TL
UT WOS:000307368400022
PM 22633921
ER
PT J
AU Corrigan, NM
Richards, TL
Treffert, DA
Dager, SR
AF Corrigan, Neva M.
Richards, Todd L.
Treffert, Darold A.
Dager, Stephen R.
TI Toward a better understanding of the savant brain
SO COMPREHENSIVE PSYCHIATRY
LA English
DT Article
ID MILD COGNITIVE IMPAIRMENT; AUTISM SPECTRUM DISORDER; EARLY
ALZHEIMERS-DISEASE; WHITE-MATTER; YOUNG-CHILDREN; FRONTOTEMPORAL
DEMENTIA; MEMORY PERFORMANCE; ASPERGER-SYNDROME; CORPUS-CALLOSUM;
CAUDATE-NUCLEUS
AB Objective: The objectives of this study are to investigate the neuroanatomy, regional brain connectivity, and neurochemistry of a prodigious artistic savant; to place these findings within the context of existing neuroimaging literature of savant syndrome; and to discuss the utility of newer imaging modalities to extend our current understanding of mechanisms underlying savant skills.
Methods: High-resolution magnetic resonance (MR) imaging, J-resolved MR spectroscopy, and diffusion tensor imaging data were acquired during a single scanning session for a 63-year-old male autistic savant with prodigious artistic skills. Regional and compartmental brain volumes, N-acetyl aspartate, choline, creatine, glutamate and gamma-aminobutyric acid concentrations, fractional anisotropy values, and white matter bundle volumes as well as axial, radial, and mean diffusivities were calculated.
Results: No gross anatomical differences were observed. By morphological assessment, cerebral volume (1362 mL) was larger than normative literature values for adult males. The corpus callosum was intact and did not exhibit abnormal structural features. The right cerebral hemisphere was 1.9% larger than the left hemisphere; the right amygdala and right caudate nuclei were 24% and 9.9% larger, respectively, compared with the left side. In contrast, the putamen was 8.3% larger on the left side. Fractional anisotropy was increased on the right side as compared with the left for 4 of the 5 bilateral regions studied (the amygdala, caudate, frontal lobe, and hippocampus). Fiber tract bundle volumes were larger on the right side for the amygdala, hippocampus, frontal lobe, and occipital lobe. Both the left and the right hippocampi had substantially increased axial and mean diffusivities as compared with those of a comparison sample of nonsavant adult males. The corpus callosum and left amygdala also exhibited high axial, radial, and mean diffusivities. MR spectroscopy revealed markedly decreased gamma-aminobutyric acid and glutamate in the parietal lobe.
Conclusions: Although examination of brain gross morphometry demonstrated no clinically remarkable abnormalities, utilization of conventional as well as newer MR imaging technologies revealed several atypical structural and chemical features that may be involved in the special skills of this prodigious savant. The multimodal imaging approach presented in this study is suitable for the evaluation of larger samples of savants with a diverse range of talents to investigate common brain features that may underlie the exceptional cognitive capabilities characteristic of savant syndrome. Given the high co-occurrence of the two syndromes, elucidating the underlying neurophysiologic basis of savant syndrome may also lead to a better understanding of autism spectrum disorder. (C) 2012 Elsevier Inc. All rights reserved.
C1 [Corrigan, Neva M.; Richards, Todd L.; Dager, Stephen R.] Univ Washington, Dept Radiol, Seattle, WA 98195 USA.
[Treffert, Darold A.] Univ Wisconsin, Sch Med, Madison, WI 54935 USA.
[Dager, Stephen R.] Univ Washington, Autism Ctr, Seattle, WA 98195 USA.
[Dager, Stephen R.] Univ Washington, Dept Bioengn, Seattle, WA 98195 USA.
RP Corrigan, NM (reprint author), Univ Washington, Dept Radiol, Seattle, WA 98195 USA.
EM nevao@u.washington.edu
FU National Institutes of Health [1P50 HD055782]
FX This study was supported by National Institutes of Health grant 1P50
HD055782.
CR Alexander AL, 2007, NEUROIMAGE, V34, P61, DOI 10.1016/j.neuroimage.2006.08.032
Allen JS, 2002, AM J PHYS ANTHROPOL, V118, P341, DOI 10.1002/ajpa.10092
[Anonymous], MED IM PROC AN VIS M
Barnea-Goraly N, 2005, COGNITIVE BRAIN RES, V25, P735, DOI 10.1016/j.cogbrainres.2005.09.013
Beaulieu C, 2005, NEUROIMAGE, V25, P1266, DOI 10.1016/j.neuroimage.2004.12.053
Blackstock GL, 2006, BLACKSTOCKS COLLECTI
Boddaert N, 2005, BRIT J PSYCHIAT, V187, P83, DOI 10.1192/bjp.187.1.83
Bor D, 2007, NEUROCASE, V13, P311, DOI 10.1080/13554790701844945
Casanova MF, 2007, AUTISM, V11, P557, DOI 10.1177/1362361307083261
Casanova MF, 2006, ACTA NEUROPATHOL, V112, P287, DOI 10.1007/s00401-006-0085-5
Cherubini A, 2010, J ALZHEIMERS DIS, V19, P1273, DOI 10.3233/JAD-2010-091186
Cho H, 2008, J KOREAN MED SCI, V23, P477, DOI 10.3346/jkms.2008.23.3.477
Coffey CE, 1998, ARCH NEUROL-CHICAGO, V55, P169, DOI 10.1001/archneur.55.2.169
Cowan R, 2009, PHILOS T R SOC B, V364, P1417, DOI 10.1098/rstb.2008.0323
Dager Stephen R, 2008, Top Magn Reson Imaging, V19, P81, DOI 10.1097/RMR.0b013e318181e0be
Dager SR, 2011, AUTISM SPECTRUM DISO, P576
Erickson KI, 2011, P NATL ACAD SCI USA, V108, P3017, DOI 10.1073/pnas.1015950108
Fehr T, 2011, NEUROCASE, V17, P360, DOI 10.1080/13554794.2010.532135
FMRIB's Diffusion Toolbox, FMRIBS DIFF TOOLB
Friedman SD, 2003, NEUROLOGY, V60, P100
Friedman SD, 2006, ARCH GEN PSYCHIAT, V63, P786, DOI 10.1001/archpsyc.63.7.786
GALABURDA AM, 1990, NEUROPSYCHOLOGIA, V28, P529, DOI 10.1016/0028-3932(90)90032-J
Ge YL, 2002, AM J NEURORADIOL, V23, P1327
Gonzalez-Garrido AA, 2002, ARCH MED RES, V33, P586, DOI 10.1016/S0188-4409(02)00404-6
Grandin T, 2011, INT M AUT RES SAN DI
Grieve SM, 2007, AM J NEURORADIOL, V28, P226
Groen W, 2010, J AM ACAD CHILD PSY, V49, P552, DOI 10.1016/j.jaac.2009.12.023
GUR RC, 1991, P NATL ACAD SCI USA, V88, P2845, DOI 10.1073/pnas.88.7.2845
Hackert VH, 2002, NEUROIMAGE, V17, P1365, DOI 10.1006/nimg.2002.1248
Harada M, 2011, J AUTISM DEV DISORD, V41, P447, DOI 10.1007/s10803-010-1065-0
Haznedar MM, 2006, AM J PSYCHIAT, V163, P1252, DOI 10.1176/appi.ajp.163.7.1252
Hollander E, 2005, BIOL PSYCHIAT, V58, P226, DOI 10.1016/j.biopsych.2005.03.040
Huang J, 2007, AM J NEURORADIOL, V28, P1943, DOI 10.3174/ajnr.A0700
Irvine KA, 2006, J NEUROIMMUNOL, V175, P69, DOI 10.1016/j.jneuroim.2006.03.002
Jenkinson M, 2001, MED IMAGE ANAL, V5, P143, DOI 10.1016/S1361-8415(01)00036-6
Jensen JE, 2005, NMR BIOMED, V18, P570, DOI 10.1002/nbm.994
Jensen JE, 2005, MAGNET RESON MED, V54, P783, DOI 10.1002/mrm.20644
KIM JH, 2010, ARCH GEN PSYCHIAT, V67, P67, DOI DOI 10.1016/J.MATURITAS.2010.05.002
Klingberg T, 2006, NEUROPSYCHOLOGIA, V44, P2171, DOI 10.1016/j.neuropsychologia.2005.11.019
Laakso MP, 1995, NEUROREPORT, V6, P2414, DOI 10.1097/00001756-199511270-00032
Langen M, 2007, BIOL PSYCHIAT, V62, P262, DOI 10.1016/j.biopsych.2006.09.040
Le Bihan D, 2001, J MAGN RESON IMAGING, V13, P534, DOI 10.1002/jmri.1076
Luria A. R., 1968, MIND MNEMONIST LITTL
MacLullich AMJ, 2002, NEUROLOGY, V59, P169
Maller JJ, 2007, PSYCHIAT RES-NEUROIM, V156, P185, DOI 10.1016/j.pscychresns.2007.06.005
Menon V, 2000, NEUROIMAGE, V12, P357, DOI 10.1006/nimg.2000.0613
Miller BL, 1998, NEUROLOGY, V51, P978
Miller BL, 2000, BRIT J PSYCHIAT, V176, P458, DOI 10.1192/bjp.176.5.458
Mosconi MW, 2009, ARCH GEN PSYCHIAT, V66, P509, DOI 10.1001/archgenpsychiatry.2009.19
Naggara O, 2006, PSYCHIAT RES-NEUROIM, V146, P243, DOI 10.1016/j.pscychresns.2006.01.005
Niogi SN, 2006, NEUROPSYCHOLOGIA, V44, P2178, DOI 10.1016/j.neuropsychologia.2006.01.011
Oblak AL, 2011, BRAIN RES, V1380, P218, DOI 10.1016/j.brainres.2010.09.021
Packard MG, 2002, ANNU REV NEUROSCI, V25, P563, DOI 10.1146/annurev.neuro.25.112701.142937
Packard MG, 2009, BRAIN RES, V1293, P121, DOI 10.1016/j.brainres.2009.03.029
Page LA, 2006, AM J PSYCHIAT, V163, P2189, DOI 10.1176/appi.ajp.163.12.2189
Papademetris X., BIOIMAGE SUITE INTEG
Pedraza O, 2004, J INT NEUROPSYCH SOC, P10
PFEFFERBAUM A, 1994, ARCH NEUROL-CHICAGO, V51, P874
Pham DL, FANTASM FUZZY NOISE
Purves D, 2011, NEUROSCIENCE, V5th
Raz N, 2004, NEUROBIOL AGING, V25, P377, DOI 10.1016/S0197-4580(03)00118-0
Sasson E, 2010, NEUROIMAGE, V50, P1231, DOI 10.1016/j.neuroimage.2009.12.079
Schumann CM, 2004, J NEUROSCI, V24, P6392, DOI 10.1523/JNEUROSCI.1297-04.2004
Sears LL, 1999, PROG NEURO-PSYCHOPH, V23, P613, DOI 10.1016/S0278-5846(99)00020-2
Sevik AE, 2010, TURK PSIKIYATR DERG, V21, P249
Song SK, 2002, NEUROIMAGE, V17, P1429, DOI 10.1006/nimg.2002.1267
Song SK, 2005, NEUROIMAGE, V26, P132, DOI 10.1016/j.neuroimage.2005.01.028
Sparks BF, 2002, NEUROLOGY, V59, P184
Treffert D., 2006, EXTRAORDINARY PEOPLE
Treffert D. A., 2010, ISLANDS GENIUS
Treffert D. A., 2006, SCI AM MIND, V17, P50
Treffert DA, 2009, PHILOS T R SOC B, V364, P1351, DOI 10.1098/rstb.2008.0326
Voelbel GT, 2006, BIOL PSYCHIAT, V60, P942, DOI 10.1016/j.biopsych.2006.03.071
Wallace GL, 2009, PHILOS T R SOC B, V364, P1425, DOI 10.1098/rstb.2008.0330
NR 74
TC 4
Z9 5
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0010-440X
J9 COMPR PSYCHIAT
JI Compr. Psychiat.
PD AUG
PY 2012
VL 53
IS 6
BP 706
EP 717
DI 10.1016/j.comppsych.2011.11.006
PG 12
WC Psychiatry
SC Psychiatry
GA 982FJ
UT WOS:000307027900007
PM 22206802
ER
PT J
AU Golubchik, P
Sever, J
Katz, N
Shoval, G
Weizman, A
AF Golubchik, Pavel
Sever, Jonathan
Katz, Nachum
Shoval, Gal
Weizman, Abraham
TI Handshaking as a measure of social responsiveness in patients with
autistic spectrum disorder
SO COMPREHENSIVE PSYCHIATRY
LA English
DT Article
ID HIGH-FUNCTIONING AUTISM; ASPERGER-SYNDROME; DIAGNOSTIC INTERVIEW;
GESTURES; CHILDREN; IMITATION; ADULTS
AB Background: Children with autistic spectrum disorder (ASD) have difficulties understanding and using nonverbal communication. Handshaking is an expressive gesture that requires adequate skills for social interaction and, because of its highly emotional characteristic for patients with ASD, may reflect their ability for social responsiveness. Unlike eye contact or complex social behavior, this gesture has not been studied in the past. We developed a rating scale intended to evaluate social responsiveness through handshaking, in patients with ASD.
Method: A group of patients with ASD (n = 20), aged 9 to 18 years, was compared with 2 age-matched groups, one of patients with attention deficit/hyperactivity disorder (n = 20) and the other is of patients with mild (IQ, 55-70) mental retardation (n = 20). To rate the handshaking behavior, we designed a Handshaking Assessment Scale (HAS) that includes 8 Yes/No items. The predefined cutoff point was a minimum of 4 "Yes" answers.
Results: Significantly more patients with ASD (13/20) had abnormal HAS (Yes answers, >= 4) than either in the attention deficit/hyperactivity disorder group (1/20; P < .0001) or in the mental retardation group (5/20; P < .025).
Conclusion: There seems to be a strong association between poor handshaking skills and autistic psychopathology, as compared with the 2 control groups. As was demonstrated by the brief and easy-to-administer HAS assessment tool, it may be advisable to use handshaking more widely as a diagnostic procedure for ASD or include it in larger diagnostic batteries. Large-scale studies are needed to substantiate our observation. (C) 2012 Elsevier Inc. All rights reserved.
C1 [Golubchik, Pavel; Sever, Jonathan; Katz, Nachum; Shoval, Gal; Weizman, Abraham] Geha Mental Hlth Ctr, IL-49100 Petah Tiqwa, Israel.
[Golubchik, Pavel; Sever, Jonathan; Katz, Nachum; Shoval, Gal; Weizman, Abraham] Tel Aviv Univ, Sackler Fac Med, IL-69978 Tel Aviv, Israel.
[Weizman, Abraham] Tel Aviv Univ, Sackler Fac Med, Felsenstein Med Res Ctr, IL-49100 Petah Tiqwa, Israel.
RP Golubchik, P (reprint author), Geha Mental Hlth Ctr, Child & Adolescent Outpatient Clin, POB 102, IL-49100 Petah Tiqwa, Israel.
EM pgolubchik@clalit.org.il
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
ATTWOOD A, 1988, J AUTISM DEV DISORD, V18, P241, DOI 10.1007/BF02211950
Baron-Cohen S, 2001, J CHILD PSYCHOL PSYC, V42, P241, DOI 10.1017/S0021963001006643
Cederlund M, 2010, RES DEV DISABIL, V31, P287, DOI 10.1016/j.ridd.2009.09.006
Constantino JN, 2003, J AUTISM DEV DISORD, V33, P427, DOI 10.1023/A:1025014929212
de Marchena A, 2010, AUTISM RES, V3, P311, DOI 10.1002/aur.159
Gillberg C, 2001, AUTISM, V5, P57, DOI 10.1177/1362361301005001006
Ham HS, 2008, J AUTISM DEV DISORD, V38, P569, DOI 10.1007/s10803-007-0417-x
Hauck M, 1995, J AUTISM DEV DISORD, V25, P579, DOI 10.1007/BF02178189
Hobson RP, 1998, J AUTISM DEV DISORD, V28, P117, DOI 10.1023/A:1026088531558
Parron C, 2008, AUTISM, V12, P261, DOI 10.1177/1362361307089520
Rogers SJ, 1996, CHILD DEV, V67, P2060, DOI 10.2307/1131609
Wechsler D, 1991, WECHSLER INTELLIGENC, V3rd
NR 13
TC 0
Z9 0
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0010-440X
J9 COMPR PSYCHIAT
JI Compr. Psychiat.
PD AUG
PY 2012
VL 53
IS 6
BP 805
EP 808
DI 10.1016/j.comppsych.2012.01.004
PG 4
WC Psychiatry
SC Psychiatry
GA 982FJ
UT WOS:000307027900020
PM 22425526
ER
PT J
AU Samson, AC
Huber, O
Gross, JJ
AF Samson, Andrea C.
Huber, Oswald
Gross, James J.
TI Emotion Regulation in Asperger's Syndrome and High-Functioning Autism
SO EMOTION
LA English
DT Article
DE emotional reactivity; emotion regulation; autism; autism spectrum
disorder; Asperger's syndrome
ID TORONTO ALEXITHYMIA SCALE; SPECTRUM QUOTIENT AQ; NEGATIVE AFFECT; GERMAN
VERSION; INDIVIDUAL-DIFFERENCES; GENERAL-POPULATION; YOUNG-CHILDREN;
DISORDER; PREVALENCE; VALIDITY
AB It is generally thought that individuals with Asperger's syndrome and high-functioning autism (AS/HFA) have deficits in Theory of Mind. These deficits have been previously linked to problems with social cognition. However, we reasoned that AS/HFA individuals' Theory of Mind deficits also might lead to problems with emotion regulation. To assess emotional functioning in AS/HFA, 27 AS/HFA adults (16 women) and 27 age-, gender-, and education-matched typically developing (TD) participants completed a battery of measures of emotion experience, labeling, and regulation. With respect to emotion experience, individuals with AS/HFA reported higher levels of negative emotions, but similar levels of positive emotions, compared with TD individuals. With respect to emotion labeling, individuals with AS/HFA had greater difficulties identifying and describing their emotions, with approximately two-thirds exceeding the cutoff for alexithymia. With respect to emotion regulation, individuals with AS/HFA used reappraisal less frequently than TD individuals and reported lower levels of reappraisal self-efficacy. Although AS/HFA individuals used suppression more frequently than TD individuals, no difference in suppression self-efficacy was found. It is important to note that these differences in emotion regulation were evident even when controlling for emotion experience and labeling. Implications of these deficits are discussed, and future research directions are proposed.
C1 [Samson, Andrea C.; Gross, James J.] Stanford Univ, Dept Psychol, Stanford, CA 94305 USA.
[Huber, Oswald] Univ Fribourg, Dept Psychol, CH-1700 Fribourg, Switzerland.
RP Samson, AC (reprint author), Stanford Univ, Dept Psychol, 450 Serra Mall,Bldg 420, Stanford, CA 94305 USA.
EM andrea.samson@stanford.edu
CR Abler B, 2009, DIAGNOSTICA, V55, P144, DOI 10.1026/0012-1924.55.3.144
Bach M, 1996, PSYCHOTHER PSYCH MED, V46, P23
Bailey PE, 2007, PSYCHIAT RES, V150, P13, DOI 10.1016/j.psychres.2006.05.024
Baron-Cohen S, 2001, J AUTISM DEV DISORD, V31, P5, DOI 10.1023/A:1005653411471
Baron-Cohen S, 1995, MINDBLINDNESS
Barrett LF, 2001, COGNITION EMOTION, V15, P713
Ben Shalom D, 2006, J AUTISM DEV DISORD, V36, P395, DOI 10.1007/s10803-006-0077-2
Berthoz S, 2005, EUR PSYCHIAT, V20, P291, DOI 10.1016/j.eurpsy.2004.06.013
CAPPS L, 1993, J CONSULT CLIN PSYCH, V61, P475, DOI 10.1037/0022-006X.61.3.475
DAWSON G, 1990, J ABNORM CHILD PSYCH, V18, P335, DOI 10.1007/BF00916569
Fitzgerald M, 2004, AM J PSYCHIAT, V161, P2134, DOI 10.1176/appi.ajp.161.11.2134
Fitzgerald M, 2006, J AUTISM DEV DISORD, V36, P573, DOI 10.1007/s10803-006-0096-z
Fladung AK, 2010, PSYCHOL MED, V40, P1703, DOI 10.1017/S0033291709992170
Franz M, 2008, SOC PSYCH PSYCH EPID, V43, P54, DOI 10.1007/s00127-007-0265-1
Freitag CM, 2007, Z KL PSYCH PSYCHOTH, V36, P280, DOI 10.1026/1616-3443.36.4.280
Frith U, 2003, PHILOS T R SOC B, V358, P459, DOI 10.1098/rstb.2002.1218
Frith U., 1989, AUTISM EXPLAINING EN
FRITH U, 1994, COGNITION, V50, P115, DOI 10.1016/0010-0277(94)90024-8
Geller L., 2005, AUTISM SPECTRUM Q, P14, DOI [10.1037/a0027975, DOI 10.1037/A0027975]
Georgiades S, 2011, J AUTISM DEV DISORD, V41, P1321, DOI 10.1007/s10803-010-1158-9
Geraerts E, 2006, BEHAV RES THER, V44, P1451, DOI 10.1016/j.brat.2005.11.001
Goldin PR, 2009, BIOL PSYCHIAT, V66, P1091, DOI 10.1016/j.biopsych.2009.07.014
Gosling SD, 2004, AM PSYCHOL, V59, P93, DOI 10.1037/0003-066X.59.2.93
Gross JJ, 2003, J PERS SOC PSYCHOL, V85, P348, DOI 10.1037/0022-3514.85.2.348
Gross JJ, 1999, COGNITION EMOTION, V13, P551, DOI 10.1080/026999399379186
Gyurak A., 2010, GEN EXP INFL EX FUNC
Hill E, 2004, J AUTISM DEV DISORD, V34, P229, DOI 10.1023/B:JADD.0000022613.41399.14
JAEDICKE S, 1994, DEV PSYCHOPATHOL, V6, P273, DOI 10.1017/S0954579400004582
Joseph RM, 1997, J AUTISM DEV DISORD, V27, P385, DOI 10.1023/A:1025853321118
KASARI C, 1990, J AUTISM DEV DISORD, V20, P87, DOI 10.1007/BF02206859
Kasari C, 1997, J AUTISM DEV DISORD, V27, P39, DOI 10.1023/A:1025869105208
Kokkonen P, 2001, COMPR PSYCHIAT, V42, P471, DOI 10.1053/comp.2001.27892
Konstantareas MM, 2006, J AUTISM DEV DISORD, V36, P143, DOI 10.1007/s10803-005-0051-4
Krohne HW, 1996, DIAGNOSTICA, V42, P139
Laurent AC, 2004, TOP LANG DISORD, V24, P286
McRae K, 2012, J RES PERS, V46, P2, DOI 10.1016/j.jrp.2011.10.003
Moriguchi Y, 2006, NEUROIMAGE, V32, P1472, DOI 10.1016/j.neuroimage.2006.04.186
Myles BS, 2003, CHILD ADOL PSYCH CL, V12, P123, DOI 10.1016/S1056-4993(02)00048-2
PARKER JDA, 1993, EUR J PERSONALITY, V7, P221, DOI 10.1002/per.2410070403
Prizant BM, 2003, INFANT YOUNG CHILD, V16, P296
Richards JM, 1999, PERS SOC PSYCHOL B, V25, P1033, DOI 10.1177/01461672992511010
Rieffe C, 2011, AUTISM, V15, P655, DOI 10.1177/1362361310366571
Salminen JK, 1999, J PSYCHOSOM RES, V46, P75, DOI 10.1016/S0022-3999(98)00053-1
Samson A. C., 2011, 8 DECADES HANS UNPUB
Samson AC, 2011, J AUTISM DEV DISORD, V41, P475, DOI 10.1007/s10803-010-1071-2
Scarpa A, 2011, BEHAV COGN PSYCHOTH, V39, P495, DOI 10.1017/S1352465811000063
Shamay-Tsoory SG, 2005, COGN BEHAV NEUROL, V18, P55, DOI 10.1097/01.wnn.0000152228.90129.99
SIFNEOS PE, 1973, PSYCHOTHER PSYCHOSOM, V22, P255
Sofronoff K, 2007, J AUTISM DEV DISORD, V37, P1203, DOI 10.1007/s10803-006-0262-3
Swart M., 2009, PLOS ONE, V4, P1
Szatmari P, 2008, J AUTISM DEV DISORD, V38, P1859, DOI 10.1007/s10803-008-0576-4
Tani P, 2004, NEUROPSYCHOBIOLOGY, V49, P64, DOI 10.1159/000076412
Klin A, 2003, CHILD ADOL PSYCH CL, V12, P1, DOI 10.1016/S1056-4993(02)00052-4
WATSON D, 1988, J PERS SOC PSYCHOL, V54, P1063, DOI 10.1037/0022-3514.54.6.1063
YIRMIYA N, 1989, J CHILD PSYCHOL PSYC, V30, P725, DOI 10.1111/j.1469-7610.1989.tb00785.x
NR 55
TC 42
Z9 44
PU AMER PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA
SN 1528-3542
J9 EMOTION
JI Emotion
PD AUG
PY 2012
VL 12
IS 4
BP 659
EP 665
DI 10.1037/a0027975
PG 7
WC Psychology, Experimental
SC Psychology
GA 982ZN
UT WOS:000307085800001
PM 22642342
ER
PT J
AU Magana, S
Parish, SL
Rose, RA
Timberlake, M
Swaine, JG
AF Magana, Sandra
Parish, Susan L.
Rose, Roderick A.
Timberlake, Maria
Swaine, Jamie G.
TI Racial and Ethnic Disparities in Quality of Health Care Among Children
with Autism and Other Developmental Disabilities
SO INTELLECTUAL AND DEVELOPMENTAL DISABILITIES
LA English
DT Article
DE autism; disparities; Latino; Black
ID FAMILY-CENTERED CARE; NATIONAL-SURVEY; INTELLECTUAL DISABILITIES;
UNITED-STATES; MEDICAL HOME; US CHILDREN; ACCESS; NEEDS; KNOWLEDGE;
SERVICES
AB We examined racial and ethnic disparities in quality of care for children with autism and other developmental disabilities and whether disparities varied for children with autism compared to children with other developmental disabilities. Analyzing data from the National Survey of Children with Special Health Care Needs (N = 5 4,414), we compared Black and Latino children to White children. We found racial and ethnic disparities on 5 of 6 quality outcomes. The interaction between race and disability status indicated that disparities in quality indicators were exacerbated among families of children with autism. These analyses suggest that children with autism, particularly those who are Latino and Black, face greater challenges in receiving high-quality
C1 [Magana, Sandra] Univ Wisconsin Madison, Waisman Ctr, Madison, WI 53705 USA.
[Parish, Susan L.; Timberlake, Maria] Brandeis Univ, Waltham, MA USA.
[Rose, Roderick A.; Swaine, Jamie G.] Univ N Carolina, Chapel Hill, NC USA.
[Magana, Sandra] Univ Wisconsin Madison, Sch Social Work, Madison, WI 53705 USA.
RP Magana, S (reprint author), Univ Wisconsin Madison, Waisman Ctr, 1500 Highland Ave, Madison, WI 53705 USA.
EM magana@waisman.wisc.edu
RI Rose, Roderick/A-3558-2013
OI Rose, Roderick/0000-0001-5309-4547
CR Abbeduto L, 2004, AM J MENT RETARD, V109, P237, DOI 10.1352/0895-8017(2004)109<237:PWACIM>2.0.CO;2
Abraido-Lanza AF, 2011, J HEALTH CARE POOR U, V22, P491, DOI 10.1353/hpu.2011.0042
Aiken L, 1991, MULTIPLE REGRESSION
ANDERSEN RM, 1995, J HEALTH SOC BEHAV, V36, P1, DOI 10.2307/2137284
Bethell CD, 2011, ACAD PEDIATR, V11, pS22, DOI 10.1016/j.acap.2010.08.011
Blumberg S. J., 2003, VITAL HLTH STAT, V1
Brachlow AE, 2007, ARCH PEDIAT ADOL MED, V161, P399, DOI 10.1001/archpedi.161.4.399
Coker TR, 2010, PEDIATRICS, V125, P1159, DOI 10.1542/peds.2009-1994
Dawson D., 2010, PEDIATRICS, V125, pe17
Department of Health and Human Services (US) Health Resources and Services Administration, 2008, NAT SURV CHILDR SPEC
Dunderstadt K. G., 2006, PEDIATRICS, V118, P1676
Engebretson J, 2011, NURS CLIN N AM, V46, P145, DOI 10.1016/j.cnur.2011.02.002
Flores G., 2010, PEDIATRICS, V125, pe183
Flores G, 2005, PEDIATRICS, V115, pE183, DOI 10.1542/peds.2004-1474
Gourdine RM, 2011, SOC WORK PUBLIC HLTH, V26, P454, DOI 10.1080/19371918.2011.579499
Graham JW, 2007, PREV SCI, V8, P206, DOI 10.1007/s11121-007-0070-9
Heidgerken AD, 2005, J AUTISM DEV DISORD, V35, P323, DOI 10.1007/s10803-005-3298-x
Jarquin VG, 2011, J DEV BEHAV PEDIATR, V32, P179, DOI 10.1097/DBP.0b013e31820b4260
Kerins Gerard, 2004, Conn Med, V68, P485
Kogan MD, 2008, PEDIATRICS, V122, pE1149, DOI 10.1542/peds.2008-1057
Krahn GL, 2006, MENT RETARD DEV D R, V12, P70, DOI 10.1002/mrdd.20098
Krauss MW, 2003, MENT RETARD, V41, P329, DOI 10.1352/0047-6765(2003)41<329:ATSMCF>2.0.CO;2
LaVeist T., 2007, J URBAN HLTH B NEW Y, V85, P11
Liptak GS, 2006, J AUTISM DEV DISORD, V36, P871, DOI 10.1007/s10803-006-0119-9
Liptak GS, 2008, J DEV BEHAV PEDIATR, V29, P152, DOI 10.1097/DBP.0b013e318165c7a0
Mandell DS, 2009, AM J PUBLIC HEALTH, V99, P493, DOI 10.2105/AJPH.2007.131243
Montes G, 2011, ACAD PEDIATR, V11, P297, DOI 10.1016/j.acap.2011.02.002
Office of the Surgeon General National Institute of Child Health and Human Development Centers for Disease Control and Prevention, 2002, CLOS GAP NAT BLUEPR
Raphael JL, 2009, ACAD PEDIATR, V9, P221, DOI 10.1016/j.acap.2009.01.011
Reichard A, 2004, MENT RETARD, V42, P181, DOI 10.1352/0047-6765(2004)42<181:POPFAC>2.0.CO;2
Research Triangle Institute, 2001, SUDAAN 8 0 COMP SOFT
Rose R. A., 2008, SOCIAL WORK RES, V32, P172
Rubin D., 1987, MULTIPLE IMPUTATION
Rust G, 2007, J AM BOARD FAM MED, V20, P105, DOI 10.3122/jabfm.2007.02.060131
SAS Institute Inc., 2004, SAS STAT 9 1 COMP SO
Schafer JL, 2002, PSYCHOL METHODS, V7, P147, DOI 10.1037//1082-989X.7.2.147
Schafer JL, 1997, ANAL INCOMPLETE MULT
Seid M, 2003, HEALTH SERV RES, V38, P1009, DOI 10.1111/1475-6773.00160
Shone LP, 2005, PEDIATRICS, V115, pE697, DOI 10.1542/peds.2004-1726
Smedley BD, 2003, UNEQUAL TREATMENT CO
Stein GL, 2008, J PALLIAT MED, V11, P1241, DOI 10.1089/jpm.2008.0130
Strickland BB, 2009, PEDIATRICS, V123, pE996, DOI 10.1542/peds.2008-2504
Thom David H., 2006, BMC MED EDUC, V6, DOI [10.1186/1472-6920-6-38, DOI 10.1186/1472-6920-6-38]
Yu Stella M, 2009, Pediatrics, V124 Suppl 4, pS414, DOI 10.1542/peds.2009-1255M
NR 44
TC 17
Z9 17
PU AMER ASSOC INTELLECTUAL DEVELOPMENTAL DISABILITIES
PI WASHINGTON
PA 444 N CAPITOL ST, NW STE 846, WASHINGTON, DC 20001-1512 USA
SN 1934-9491
J9 INTELLECT DEV DISAB
JI Intellect. Dev. Disabil.
PD AUG
PY 2012
VL 50
IS 4
BP 287
EP 299
DI 10.1352/1934-9556-50.4.287
PG 13
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA 985YV
UT WOS:000307307300001
PM 22861130
ER
PT J
AU Golnik, A
Maccabee-Ryaboy, N
Scal, P
Wey, A
Gaillard, P
AF Golnik, Allison
Maccabee-Ryaboy, Nadia
Scal, Peter
Wey, Andrew
Gaillard, Philippe
TI Shared Decision Making: Improving Care for Children with Autism
SO INTELLECTUAL AND DEVELOPMENTAL DISABILITIES
LA English
DT Article
DE autism; shared decision making; primary care; medical home
ID SPECTRUM DISORDERS; MEDICAL HOME; PATIENT SATISFACTION; ALTERNATIVE
MEDICINE; NATIONAL-SURVEY; FAMILY STRESS; PATIENTS WANT; OUTCOMES;
PARENTS; HEALTH
AB We assessed the extent to which parents of children with autism spectrum disorder report that they are engaged in shared decision making. We measured the association between shared decision making and (a) satisfaction with care, (b) perceived guidance regarding controversial issues in autism spectrum disorder, and (c) perceived assistance navigating the multitude of treatment options. Surveys assessing primary medical care and decision-making processes were developed on the basis of the U. S. Department of Health and Human Service's Consumer Assessment of Healthcare Providers and Systems survey. In May 2009, after pilot testing, we sent surveys to 203 parents of children from ages 3 to 18 with International Classification of Diseases-9 and parent-confirmed autism spectrum disorder diagnoses. The response rate was 64%. Controlling for key demographic variables, parents of children with autism spectrum disorder reporting higher levels of shared decision making reported significantly greater satisfaction with the overall quality of their child's health care (p <= .0001). Parents reporting higher levels of shared decision making were also significantly more likely to report receiving guidance on the many treatment options (p = .0002) and controversial issues related to autism spectrum disorder (p = .0322). In this study, shared decision making was associated with higher parent satisfaction and improved guidance regarding treatments and controversial issues within primary care for children with autism spectrum disorder.
C1 [Golnik, Allison] Univ Minnesota, Dept Pediat, Div Gen Pediat, Minneapolis, MN 55414 USA.
RP Golnik, A (reprint author), Univ Minnesota, Dept Pediat, Div Gen Pediat, 717 Delaware St SE,3rd Floor,Room 370E, Minneapolis, MN 55414 USA.
EM Allison.golnik@gmail.com
CR Agency for Healthcare Research and Quality, 2010, SURV TOOLS ADV PAT C
American Academy of Pediatrics, 2002, PEDIATRICS 1, V110, P184
DICKENS MD, 1992, PEDIATRICS, V90, P774
American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th
[Anonymous], 2010, IAN RES REP FAM ST 1
Ashwood P, 2006, J LEUKOCYTE BIOL, V80, P1, DOI 10.1189/jlb.1205707
Baker-Ericzen MJ, 2005, RES PRACT PERS SEV D, V30, P194, DOI 10.2511/rpsd.30.4.194
BOUMA R, 1990, J CLIN PSYCHOL, V46, P722, DOI 10.1002/1097-4679(199011)46:6<722::AID-JCLP2270460605>3.0.CO;2-6
Brachlow AE, 2007, ARCH PEDIAT ADOL MED, V161, P399, DOI 10.1001/archpedi.161.4.399
Buie T, 2010, PEDIATRICS, V125, pS1, DOI 10.1542/peds.2009-1878C
Center for Disease Control and Prevention, 2009, INT CLASS DIS 9 REV
Charles C., 1997, SHARED DECISIONMAKIN
Child and Adolescent Health Measurement Initiative, 2008, NAT SURV CHILDR SPEC
Clark NM, 1998, PEDIATRICS, V101, P831, DOI 10.1542/peds.101.5.831
DAWES PJD, 1994, J ROY SOC MED, V87, P149
Dempsey I, 2008, TOP EARLY CHILD SPEC, V28, P42, DOI 10.1177/0271121408316699
Dunst CJ, 2007, MENT RETARD DEV D R, V13, P370, DOI 10.1002/mrdd.20176
Fiks AG, 2010, PEDIATRICS, V126, P306, DOI 10.1542/peds.2010-0526
Freed GL, 2010, PEDIATRICS, V125, P654, DOI 10.1542/peds.2009-1962
Frosch DL, 1999, AM J PREV MED, V17, P285, DOI 10.1016/S0749-3797(99)00097-5
Golnik A, 2009, PEDIATRICS, V123, P966, DOI 10.1542/peds.2008-1321
Gravel K, 2006, IMPLEMENT SCI, V1, DOI 10.1186/1748-5908-1-16
Gray E. G., 1992, AUSTR NZ J DEV DISAB, V18, P83
GREENFIELD S, 1988, J GEN INTERN MED, V3, P448, DOI 10.1007/BF02595921
Hanson E, 2007, J AUTISM DEV DISORD, V37, P628, DOI 10.1007/s10803-006-0192-0
Harrington JW, 2006, J DEV BEHAV PEDIATR, V27, pS156, DOI 10.1097/00004703-200604002-00014
KAPLAN SH, 1989, MED CARE, V27, pS110, DOI 10.1097/00005650-198903001-00010
Kogan M. D., 2008, PEDIATRICS, V122, P49
Liptak Gregory S, 2006, J Pediatr Health Care, V20, P245, DOI 10.1016/j.pedhc.2005.12.008
Lord C, 2010, SOCIAL POLICY REPORT, V24, P1
Lord C, 2005, J AUTISM DEV DISORD, V35, P695, DOI 10.1007/s10803-005-0017-6
Merenstein D, 2005, PEDIATRICS, V116, P1267, DOI 10.1542/peds.2005-0486
Myers SM, 2007, PEDIATRICS, V120, P1162, DOI 10.1542/peds.2007-2362
National Autism Center, 2009, NAT STAND REP
Olley G., 1999, AUSTIM HIST OVERVIEW
RODRIGUE JR, 1990, J CLIN CHILD PSYCHOL, V19, P371, DOI 10.1207/s15374424jccp1904_9
Roter Deborah, 1992, DOCTORS TALKING PATI
Rhoades Rachel A, 2007, BMC Pediatr, V7, P37, DOI 10.1186/1471-2431-7-37
Sanders JL, 1997, CHILD FAM BEHAV THER, V19, P15, DOI 10.1300/J019v19n04_02
Saultz JW, 2004, ANN FAM MED, V2, P445, DOI 10.1370/afm.91
Shelton T. L., 1994, FAMILYCENTERED CARE
Silverman C, 2007, ARCH PEDIAT ADOL MED, V161, P392, DOI 10.1001/archpedi.161.4.392
STEWART MA, 1995, CAN MED ASSOC J, V152, P1423
Strickland B, 2004, PEDIATRICS, V113, P1485
STRULL WM, 1984, JAMA-J AM MED ASSOC, V252, P2990, DOI 10.1001/jama.252.21.2990
Whitney SN, 2003, MED DECIS MAKING, V23, P275, DOI 10.1177/0272989X03256006
WILLIAMS B, 1994, SOC SCI MED, V38, P509, DOI 10.1016/0277-9536(94)90247-X
NR 47
TC 3
Z9 3
PU AMER ASSOC INTELLECTUAL DEVELOPMENTAL DISABILITIES
PI WASHINGTON
PA 444 N CAPITOL ST, NW STE 846, WASHINGTON, DC 20001-1512 USA
SN 1934-9491
J9 INTELLECT DEV DISAB
JI Intellect. Dev. Disabil.
PD AUG
PY 2012
VL 50
IS 4
BP 322
EP 331
DI 10.1352/1934-9556-50.4.322
PG 10
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA 985YV
UT WOS:000307307300004
PM 22861133
ER
PT J
AU Pinkham, AE
Sasson, NJ
Beaton, D
Abdi, H
Kohler, CG
Penn, DL
AF Pinkham, Amy E.
Sasson, Noah J.
Beaton, Derek
Abdi, Herve
Kohler, Christian G.
Penn, David L.
TI Qualitatively Distinct Factors Contribute to Elevated Rates of Paranoia
in Autism and Schizophrenia
SO JOURNAL OF ABNORMAL PSYCHOLOGY
LA English
DT Article
DE paranoia; discriminant correspondence analysis; cynicism; social
cognition
ID HIGH-FUNCTIONING AUTISM; SPECTRUM DISORDERS; SOCIAL-COGNITION;
NONCLINICAL POPULATION; PERSECUTORY DELUSIONS; DIAGNOSTIC INTERVIEW;
GENERAL-POPULATION; MIND; BELIEFS; SELF
AB A converging body of clinical and empirical reports indicates that autism features elevated rates of paranoia comparable to those of individuals with paranoid schizophrenia. However, the distinct developmental courses and symptom manifestations of these two disorders suggest that the nature of paranoid ideation may differ between them in important and meaningful ways. To evaluate this hypothesis, we compared patterns of responses on the Paranoia Scale between actively paranoid individuals with schizophrenia (SCZP), individuals with schizophrenia who were not actively paranoid (SCZNP), adults with an Autism Spectrum Disorder (ASD), and healthy controls. Despite an overall similar level of heightened paranoia in the ASD and SCZP groups, discriminant correspondence analysis (DiCA) revealed that these groups were characterized by unique underlying factors. Paranoia in the SCZP group was defined by a factor based upon victimization, suspicion, and threat of harm. Whereas paranoia in the ASD group was partially characterized by this factor, it was distinguished from SCZP by an additional pattern of responses reflective of increased social cynicism. These findings indicate that paranoia in ASD is supported by qualitative factors distinct from schizophrenia and highlight mechanistic differences in the formation of paranoid ideation that may inform the development of disorder-specific treatments.
C1 [Pinkham, Amy E.] So Methodist Univ, Dept Psychol, Dallas, TX 75275 USA.
[Sasson, Noah J.; Beaton, Derek; Abdi, Herve] Univ Texas Dallas, Sch Behav & Brain Sci, Dallas, TX 75230 USA.
[Kohler, Christian G.] Univ Penn, Sch Med, Dept Psychiat, Philadelphia, PA 19104 USA.
[Penn, David L.] Univ N Carolina, Dept Psychol, Chapel Hill, NC USA.
RP Pinkham, AE (reprint author), So Methodist Univ, Dept Psychol, POB 750442, Dallas, TX 75275 USA.
EM apinkham@mail.smu.edu
CR Abdi H, 2010, WILEY INTERDISCIP RE, V2, P433, DOI DOI 10.1002/WICS.101
Abdi H., 2010, ENCY RES DESIGN, P267
Abdi H, 2007, ENCY MEASUREMENT STA, P651
Abdi H., 2007, ENCY MEASUREMENT STA, P270
Abdi H, 2009, NEUROIMAGE, V45, P89, DOI 10.1016/j.neuroimage.2008.11.008
Abell F, 2005, AUTISM, V9, P515, DOI 10.1177/1362361305057857
Abu-Akel A, 2000, PSYCHOL MED, V30, P735, DOI 10.1017/S0033291799002123
Ballard C, 2000, J AFFECT DISORDERS, V59, P97, DOI 10.1016/S0165-0327(99)00057-9
Baron-Cohen S, 1995, MINDBLINDNESS
Bentall RP, 2009, ARCH GEN PSYCHIAT, V66, P236, DOI 10.1001/archgenpsychiatry.2009.1
Bentall RP, 2001, CLIN PSYCHOL REV, V21, P1143, DOI 10.1016/S0272-7358(01)00106-4
Blackshaw AJ, 2001, AUTISM, V5, P147, DOI 10.1177/1362361301005002005
Bond MH, 2004, EUR J PERSONALITY, V18, P177, DOI 10.1002/per.509
Bora E, 2009, SCHIZOPHR RES, V109, P1, DOI 10.1016/j.schres.2008.12.020
Chadwick PDJ, 2005, PSYCHOPATHOLOGY, V38, P327, DOI 10.1159/000089453
TROWER P, 1995, CLIN PSYCHOL-SCI PR, V2, P263
Chan G, 2011, ADDICTION, V106, P1146, DOI 10.1111/j.1360-0443.2011.03390.x
Chernick MR, 2008, WILEY SER PROBAB ST, P1
Chi Y., 2012, WILEY INTERDISCIPLIN, V4, P35, DOI [10.1002/wics.185, DOI 10.1002/WICS.185]
Churchill A, 2010, FOOD QUAL PREFER, V21, P1108, DOI 10.1016/j.foodqual.2010.07.006
Combs Dennis R, 2007, Cogn Neuropsychiatry, V12, P537, DOI 10.1080/13546800701707306
Costello AB, 2005, PRACTICAL ASSESSMENT, V10, P1, DOI DOI 10.1316/S0782-051X03024046-9
Craig JS, 2004, SCHIZOPHR RES, V69, P29, DOI 10.1016/S0920-9964(03)00154-3
Dumais A, 2011, SCHIZOPHR RES, V130, P234, DOI 10.1016/j.schres.2011.02.024
Efron B., 1993, INTRO BOOTSTRAP
Ellett L, 2003, J NERV MENT DIS, V191, P425
FENIGSTEIN A, 1992, J PERS SOC PSYCHOL, V62, P129, DOI 10.1037/0022-3514.62.1.129
First M, 2002, STRUCTURED CLIN INTE
Freeman D, 2007, CLIN PSYCHOL REV, V27, P425, DOI 10.1016/j.cpr.2006.10.004
Freeman D, 2005, BRIT J PSYCHIAT, V186, P427, DOI 10.1192/bjp.186.5.427
Freeman D, 2008, BRIT J PSYCHIAT, V192, P258, DOI 10.1192/bjp.bp.107.044677
Frith CD, 2004, PSYCHOL MED, V34, P385, DOI 10.1017/S0033291703001326
Green CEL, 2008, PSYCHOL MED, V38, P101, DOI 10.1017/S0033291707001638
Greenacre M., 2007, CORRES ANAL PRACTICE
HAPPE FGE, 1994, J AUTISM DEV DISORD, V24, P129, DOI 10.1007/BF02172093
Hare D. J., 1997, AUTISM, V1, P215, DOI [10.1177/1362361397012007, DOI 10.1177/1362361397012007]
Hwang DH, 2002, BIOINFORMATICS, V18, P1184, DOI 10.1093/bioinformatics/18.9.1184
Kay SR, 1992, POSITIVE NEGATIVE SY
Kraepelin E, 1907, TXB PSYCHIAT
Lebart L, 1984, MULTIVARIATE DESCRIP
Leung K, 2004, ADV EXP SOC PSYCHOL, V36, P119, DOI 10.1016/S0065-2601(04)36003-X
Lord C., 1999, AUTISM DIAGNOSTIC OB
LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
Manschreck TC, 2006, CAN J PSYCHIAT, V51, P114
Martin JA, 2001, BRIT J CLIN PSYCHOL, V40, P261, DOI 10.1348/014466501163670
Montag C, 2011, PSYCHIAT RES, V186, P203, DOI 10.1016/j.psychres.2010.09.006
North AS, 2008, J FORENSIC PSYCHI PS, V19, P323, DOI 10.1080/14789940701871621
NURNBERGER JI, 1994, ARCH GEN PSYCHIAT, V51, P849
Olfson M, 2002, AM J PSYCHIAT, V159, P1412, DOI 10.1176/appi.ajp.159.8.1412
Penn DL, 2008, SCHIZOPHRENIA BULL, V34, P408, DOI 10.1093/schbul/sbn014
Peters ER, 1999, SCHIZOPHRENIA BULL, V25, P553
Pinkham AE, 2008, SCHIZOPHR RES, V99, P164, DOI 10.1016/j.schres.2007.10.024
R Development Core Team, 2010, R LANG ENV STAT COMP
Roberts DL, 2004, SOCIAL COGNITI UNPUB
Rossler W, 2007, SCHIZOPHR RES, V92, P1, DOI 10.1016/j.schres.2007.01.002
Sasson NJ, 2011, J NEURODEV DISORD, V3, P87, DOI 10.1007/s11689-010-9068-x
Tellegen A., 2003, MMPI 2 RESTRUCTURED
Turner-Brown LM, 2008, J AUTISM DEV DISORD, V38, P1777, DOI 10.1007/s10803-008-0545-y
van Os J, 1999, SOC PSYCH PSYCH EPID, V34, P459, DOI 10.1007/s001270050220
Walter H, 2009, SOC COGN AFFECT NEUR, V4, P166, DOI 10.1093/scan/nsn047
Williams LJ, 2010, J SPEECH LANG HEAR R, V53, P1372, DOI 10.1044/1092-4388(2010/08-0141)
Wing J. K., 1974, MEASUREMENT CLASSIFI, V9
Wing L., 1996, AUTISTIC SPECTRUM GU
Woodbury-Smith MR, 2010, J PSYCHIATR NEUROSCI, V35, P360, DOI [10.1503/jpn.100130, 10.1503/jpm.100130]
Woods SW, 2003, J CLIN PSYCHIAT, V64, P663
Yirmiya N, 1998, PSYCHOL BULL, V124, P283, DOI 10.1037/0033-2909.124.3.283
NR 66
TC 3
Z9 3
PU AMER PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA
SN 0021-843X
EI 1939-1846
J9 J ABNORM PSYCHOL
JI J. Abnorm. Psychol.
PD AUG
PY 2012
VL 121
IS 3
BP 767
EP 777
DI 10.1037/a0028510
PG 11
WC Psychology, Clinical; Psychology, Multidisciplinary
SC Psychology
GA 988IA
UT WOS:000307482700022
PM 22686868
ER
PT J
AU Abramowicz, JS
AF Abramowicz, Jacques S.
TI Ultrasound and Autism Association, Link, or Coincidence?
SO JOURNAL OF ULTRASOUND IN MEDICINE
LA English
DT Review
DE autism; bioeffects; fetal ultrasound; obstetrics; safety
ID PERVASIVE DEVELOPMENTAL DISORDERS; PERINATAL RISK-FACTORS; SPECTRUM
DISORDERS; DIAGNOSTIC ULTRASOUND; PRENATAL ULTRASOUND; SUBSEQUENT
HANDEDNESS; NEURONAL MIGRATION; NEONATAL FACTORS; PARENTAL AGE; PATERNAL
AGE
AB Autism spectrum disorders (ASDs) affect an estimated 1% of children in the United States. The etiology is probably multifactorial, including genetic components and exposure to infections, toxins, and other environmental factors, particularly unfavorable perinatal and neonatal conditions. There has been an increase in the frequency of diagnosis of ASDs over the last 20 years with a parallel increase in the use of obstetric diagnostic ultrasound, with prenatal ultrasound exposure mentioned as the possible main etiology for autism "epidemics." Central nervous system alterations have been described in ASDs, and certain similar changes have been described in animals after exposure to ultrasound. However, analysis of in utero exposure in humans has failed to show harmful effects in neonates or children, particularly in school performance, attention disorders, and behavioral changes. There is no independently confirmed peer-reviewed published evidence that a cause-effect relationship exists between in utero exposure to clinical ultrasound and development of ASDs in childhood. Ultrasound is a form of energy with effects in the tissues it traverses, and its use should be restricted to medical indications, by trained professionals, for as short a period and as low an intensity as compatible with accurate diagnosis.
C1 [Abramowicz, Jacques S.] Rush Univ, Dept Obstet & Gynecol, Chicago, IL 60612 USA.
[Abramowicz, Jacques S.] Rush Univ, Rush Fetal & Neonatal Med Ctr, Chicago, IL 60612 USA.
RP Abramowicz, JS (reprint author), Rush Univ, Dept Obstet & Gynecol, 1653 W Congress Pkwy, Chicago, IL 60612 USA.
EM jacques_abramowicz@rush.edu
CR Abramowicz JS, 2008, J ULTRAS MED, V27, P541
Abramowicz JS, 2007, ULTRASOUND OBST GYN, V29, P363, DOI 10.1002/uog.3983
American Psychiatric Association, 2000, DIAGN STAT MAN MENT
Ang ESBC, 2006, P NATL ACAD SCI USA, V103, P12903, DOI 10.1073/pnas.0605294103
Autism Genome Project, AGP MEMB CURR PROJ P
Barbaresi WJ, 2009, J AUTISM DEV DISORD, V39, P464, DOI 10.1007/s10803-008-0645-8
Beard CM, 2011, MED HYPOTHESES, V77, P15, DOI 10.1016/j.mehy.2011.03.013
Bilder D, 2009, PEDIATRICS, V123, P1293, DOI 10.1542/peds.2008-0927
Blaxill MF, 2004, PUBLIC HEALTH REP, V119, P536, DOI 10.1016/j.phr.2004.09.003
Bower H, 1999, BRIT MED J, V318, P1643
Casanova MF, 2007, BRAIN PATHOL, V17, P422, DOI 10.1111/j.1750-3639.2007.00100.x
Centers for Disease Control and Prevention, 2007, MMWR SURVEILL SUMM, V56, P12
Centers for Disease Control and Prevention, STUD EXPL EARL DEV S
Centers for Disease Control and Prevention, 2009, MMWR-MORBID MORTAL W, V58, P1
Chen W, 2004, PSYCHOL MED, V34, P543, DOI 10.1017/S0033291703001259
Childhood Autism Risks From Genetics and the Environment (CHARGE), BE CHARG
Chung KinKee, 2009, J Am Osteopath Assoc, V109, P384
Coleman M., 2012, AUTISMS
Coleman M, 2005, NEUROLOGY AUTISM, P3
Courchesne E, 2011, JAMA-J AM MED ASSOC, V306, P2001, DOI 10.1001/jama.2011.1638
COYLE I, 1976, PHARMACOL BIOCHEM BE, V4, P191, DOI 10.1016/0091-3057(76)90014-9
Croen LA, 2005, PEDIATRICS, V115, pE135, DOI 10.1542/peds.2004-1870
Croen LA, 2007, ARCH PEDIAT ADOL MED, V161, P334, DOI 10.1001/archpedi.161.4.334
Croen LA, 2011, ARCH GEN PSYCHIAT, V68, P1104, DOI 10.1001/archgenpsychiatry.2011.73
DeStefano F, 1999, LANCET, V353, P1987, DOI 10.1016/S0140-6736(99)00160-9
DEVI PU, 1995, RADIAT RES, V141, P314, DOI 10.2307/3579009
Dhillon S, 2011, CURR GENOMICS, V12, P322, DOI 10.2174/138920211796429745
Dufour-Rainfray D, 2011, NEUROSCI BIOBEHAV R, V35, P1234
Durkin MS, 2008, AM J EPIDEMIOL, V168, P1268, DOI 10.1093/aje/kwn250
Early Autism Risk Longitudinal Investigation (EARLI), FIND CLUES AUT BEG P
FEIN D, 1985, J AUTISM DEV DISORD, V15, P323, DOI 10.1007/BF01531502
Fidler DJ, 2000, DEV MED CHILD NEUROL, V42, P737, DOI 10.1017/S0012162200001365
Fombonne E, 2001, PEDIATRICS, V107, P411, DOI 10.1542/peds.107.2.411
Fowlkes JB, 2008, J ULTRAS MED, V27, P503
Gabis L, 2010, PEDIATR NEUROL, V43, P300, DOI 10.1016/j.pediatrneurol.2010.05.022
Gardener H, 2011, PEDIATRICS, V128, P344, DOI 10.1542/peds.2010-1036
Girirajan S, 2011, ANNU REV GENET, V45, P203, DOI 10.1146/annurev-genet-102209-163544
Glasson EJ, 2004, ARCH GEN PSYCHIAT, V61, P618, DOI 10.1001/archpsyc.61.6.618
Godlee F, 2011, BRIT MED J, V342, DOI 10.1136/bmj.c7452
Goez H, 2008, J CHILD NEUROL, V23, P151, DOI 10.1177/0883073807307978
Grafodatskaya D, 2010, J AM ACAD CHILD PSY, V49, P794, DOI 10.1016/j.jaac.2010.05.005
Grether JK, 2010, J AUTISM DEV DISORD, V40, P238, DOI 10.1007/s10803-009-0859-4
Harding B, 2002, GREENFIELDS NEUROPAT, P357
Heikkila K, 2011, ULTRASOUND OBST GYN, V37, P638, DOI 10.1002/uog.8962
Hobbs K, 2007, BIOL PSYCHIAT, V62, P1048, DOI 10.1016/j.biopsych.2007.03.020
Houston LE, 2011, J ULTRAS MED, V30, P21
Hultman CM, 2004, LANCET, V364, P485, DOI 10.1016/S0140-6736(04)16825-6
Hultman CM, 2011, MOL PSYCHIATR, V16, P1203, DOI 10.1038/mp.2010.121
Hultman CM, 2002, EPIDEMIOLOGY, V13, P417, DOI 10.1097/01.EDE.0000016968.14007.E6
Jabr F., 2012, SCI AM
Jensh RP, 1999, TERATOLOGY, V59, P240, DOI 10.1002/(SICI)1096-9926(199904)59:4<240::AID-TERA10>3.0.CO;2-V
Johnson S, 2010, J PEDIAT, V156, P525
Juul-Dam N, 2001, PEDIATRICS, V107, part. no., DOI 10.1542/peds.107.4.e63
Keller F, 2003, MOL NEUROBIOL, V28, P1, DOI 10.1385/MN:28:1:1
Kieler H, 1998, EARLY HUM DEV, V50, P233, DOI 10.1016/S0378-3782(97)00097-2
Kieler H, 2001, EPIDEMIOLOGY, V12, P618, DOI 10.1097/00001648-200111000-00007
King M, 2009, INT J EPIDEMIOL, V38, P1224, DOI 10.1093/ije/dyp261
Kolevzon A, 2007, ARCH PEDIAT ADOL MED, V161, P326, DOI 10.1001/archpedi.161.4.326
Krakowiak P, 2012, PEDIATRICS, V129, P1121
Landrigan PJ, 2010, CURR OPIN PEDIATR, V22, P219, DOI 10.1097/MOP.0b013e328336eb9a
Latif AHA, 2007, AUTISM, V11, P479, DOI 10.1177/1362361307083256
Lender D, 2012, VACCINE NATION
Lenoir P, 2009, ENCEPHALE, V35, P36, DOI 10.1016/j.encep.2007.12.011
Li J, 2009, PEDIATRICS, V123, P1102, DOI 10.1542/peds.2008-1734
Liu KY, 2010, AM J SOCIOL, V115, P1387
Mancini J, 2001, DEV MED CHILD NEUROL, V43, P52, DOI 10.1017/S0012162201000081
Marsal K, 2005, ULTRASOUND OBST GYN, V25, P211, DOI 10.1002/uog.1864
Miles JH, 2011, GENET MED, V13, P278, DOI 10.1097/GIM.0b013e3181ff67ba
Muhle R, 2004, PEDIATRICS, V113, pE472, DOI 10.1542/peds.113.5.e472
Newschaffer CJ, 2006, PEDIATRICS, V117, P1436, DOI 10.1542/peds.2005-2834
Newschaffer CJ, 2007, ANNU REV PUBL HEALTH, V28, P235, DOI 10.1146/annurev.publhealth.28.021406.144007
NORTON S, 1991, J ULTRAS MED, V10, P69
Olson Christopher D, 2009, J Am Osteopath Assoc, V109, P71
Pardo CA, 2007, BRAIN PATHOL, V17, P434, DOI 10.1111/j.1750-3639.2007.00102.x
Parner ET, 2012, ANN EPIDEMIOL, V22, P143, DOI 10.1016/j.annepidem.2011.12.006
Piven J, 1997, CURR OPIN NEUROBIOL, V7, P708, DOI 10.1016/S0959-4388(97)80093-1
Polsek D, 2011, TRANSL NEUROSCI, V2, P256, DOI 10.2478/s13380-011-0024-3
Rice C, 2010, DISABIL HEALTH J, V3, P186, DOI 10.1016/j.dhjo.2009.10.008
Rodgers C., 2006, MIDWIFERY TODAY INT, V80, P16
Rodgers C, 2006, MIDWIFERY TODAY INT, P66
Rodier PM, 1996, J COMP NEUROL, V370, P247, DOI 10.1002/(SICI)1096-9861(19960624)370:2<247::AID-CNE8>3.0.CO;2-2
Rodier PM, 2002, DEV PSYCHOPATHOL, V14, P537, DOI 10.1017/S0954579402003085
Ronald A, 2011, AM J MED GENET B, V156B, P255, DOI 10.1002/ajmg.b.31159
Rutter M, 2005, J INTELL DISABIL RES, V49, P231, DOI 10.1111/j.1365-2788.2005.00676.x
Rutter M, 2005, ACTA PAEDIATR, V94, P2, DOI 10.1080/08035250410023124
Salvesen K, 1994, OBSTET EVENTS DEV SE, P107
Salvesen Kjell A, 2002, Eur J Ultrasound, V15, P165, DOI 10.1016/S0929-8266(02)00038-1
SALVESEN KA, 1992, ULTRASOUND OBST GYN, V2, P243, DOI 10.1046/j.1469-0705.1992.02040243.x
Salvesen KA, 2011, ULTRASOUND OBST GYN, V38, P267, DOI 10.1002/uog.9055
Salvesen KA, 1999, ULTRASOUND OBST GYN, V13, P241, DOI 10.1046/j.1469-0705.1999.13040241.x
SALVESEN KA, 1993, BRIT MED J, V307, P1064
SALVESEN KA, 1993, BRIT MED J, V307, P159
Salvesen KA, 2007, PROG BIOPHYS MOL BIO, V93, P295, DOI 10.1016/j.pbiomolbio.2006.07.013
SCHEIDT PC, 1978, AM J OBSTET GYNECOL, V131, P743
Schieve LA, 2007, PEDIATRICS, V119, pS114, DOI 10.1542/peds.2006-2089Q
Schneider-Kolsky ME, 2009, INT J DEV NEUROSCI, V27, P677, DOI 10.1016/j.ijdevneu.2009.07.007
Shattuck PT, 2006, PEDIATRICS, V117, P1028, DOI 10.1542/peds.2005-1516
Sheiner E, 2008, J ULTRAS MED, V27, P499
SIDMAN RL, 1973, BRAIN RES, V62, P1, DOI 10.1016/0006-8993(73)90617-3
Spence Sarah J., 2006, UNDERSTANDING AUTISM, P1
Stalberg K, 2007, EPIDEMIOLOGY, V18, P577, DOI 10.1097/EDE.0b013e318126c102
Stalberg K, 2008, THESIS UPPSALA U UPP
STARK CR, 1984, OBSTET GYNECOL, V63, P194
Szatmari P, 2011, BMJ-BRIT MED J, V342, DOI 10.1136/bmj.d2456
TARANTAL AF, 1989, TERATOLOGY, V39, P149, DOI 10.1002/tera.1420390207
Torloni MR, 2009, ULTRASOUND OBST GYN, V33, P599, DOI 10.1002/uog.6328
Wakefield AJ, 1998, LANCET, V351, P637, DOI 10.1016/S0140-6736(97)11096-0
Waldman Michael, 2006, DOES TELEVISION CAUS
Wang LS, 2010, BMC MED GENET, V11, DOI 10.1186/1471-2350-11-134
Weintraub K, 2011, NATURE, V479, P22, DOI 10.1038/479022a
Whitehouse AJO, 2011, J AUTISM DEV DISORD, V41, P122, DOI 10.1007/s10803-010-1019-6
Whitworth M, 2010, COCHRANE DB SYST REV, V4, DOI DOI 10.1002/14651858.CD007058.PUB2
Williams EL, 2010, MED HYPOTHESES, V75, P53, DOI 10.1016/j.mehy.2010.01.027
Williams G, 2001, DEV MED CHILD NEUROL, V43, P202, DOI 10.1017/S001216220100038X
Wing L, 2011, RES DEV DISABIL, V32, P768, DOI 10.1016/j.ridd.2010.11.003
NR 115
TC 5
Z9 5
PU AMER INST ULTRASOUND MEDICINE
PI LAUREL
PA SUBSCRIPTION DEPT, 14750 SWEITZER LANE, STE 100, LAUREL, MD 20707-5906
USA
SN 0278-4297
J9 J ULTRAS MED
JI J. Ultrasound Med.
PD AUG
PY 2012
VL 31
IS 8
BP 1261
EP 1269
PG 9
WC Acoustics; Radiology, Nuclear Medicine & Medical Imaging
SC Acoustics; Radiology, Nuclear Medicine & Medical Imaging
GA 981QS
UT WOS:000306985100015
PM 22837291
ER
PT J
AU Arnold, GL
Salazar, D
Neidich, JA
Suwannarat, P
Graham, BH
Lichter-Konecki, U
Bosch, AM
Cusmano-Ozog, K
Enns, G
Wright, EL
Lanpher, BC
Owen, NN
Lipson, MH
Cerone, R
Levy, P
Wong, LJC
Dezsofi, A
AF Arnold, Georgianne L.
Salazar, Denise
Neidich, Julie A.
Suwannarat, Pim
Graham, Brett H.
Lichter-Konecki, Uta
Bosch, Annet M.
Cusmano-Ozog, Kristina
Enns, Greg
Wright, Erica L.
Lanpher, Brendan C.
Owen, Natalie N.
Lipson, Mark H.
Cerone, Roberto
Levy, Paul
Wong, Lee-Jun C.
Dezsofi, Antal
TI Outcome of infants diagnosed with 3-methyl-crotonyl-CoA-carboxylase
deficiency by newborn screening
SO MOLECULAR GENETICS AND METABOLISM
LA English
DT Article
DE 3-Methylcrotonyl CoA carboxylase deficiency; Organic acidemia; Newborn
screening
ID 3-METHYLCROTONYL-COA CARBOXYLASE DEFICIENCY; SIBS
AB Introduction: 3-Methyl CoA carboxylase (3-MCC) deficiency is an inborn error of metabolism in the catabolism of the amino acid leucine. Original reports suggested this disorder was associated with significant neurological and biochemical effects. However newborn screening has identified a higher than expected incidence of this disorder with apparent normal outcome in most cases.
Method: A retrospective analysis of thirty-five cases of 3-MCC deficiency identified by newborn screening and diagnosed by enzyme or molecular analysis.
Results: There was a strong inverse correlation between initial C5OH level and residual enzyme activity. A few reports of hypoglycemia, ketosis, poor feeding/failure to thrive or fasting intolerance were reported, but there was no clear relationship between symptoms and residual enzyme activity. Developmental outcome included several children with mental retardation (including one with Down syndrome and one with schizencephaly) and two with Autism Spectrum disorders but there was no apparent relationship to residual enzyme activity. Free carnitine deficiency was relatively common.
Discussion: Although residual enzyme activity was clearly related to metabolite elevation, there was no apparent relationship with other measures of outcome. The number of reports of neurologic abnormalities or metabolic symptoms (poor feeding, hypoglycemia, fasting intolerance, etc.) is concerning, but the significance is unclear in this retrospective sample. (C) 2012 Elsevier Inc. All rights reserved.
C1 [Arnold, Georgianne L.] Univ Pittsburgh, Dept Pediat, Med Ctr, Pittsburgh, PA 15260 USA.
[Salazar, Denise] Quest Diagnost, San Juan Capistrano, CA USA.
[Neidich, Julie A.] Ambry Genet, Aliso Viejo, CA USA.
[Suwannarat, Pim] Kaiser Permanente San Francisco Med Ctr, San Francisco, CA USA.
[Graham, Brett H.; Wong, Lee-Jun C.] Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA.
[Lichter-Konecki, Uta; Cusmano-Ozog, Kristina; Lanpher, Brendan C.] George Washington Univ, Dept Pediat, Childrens Natl Med Ctr, Washington, DC 20052 USA.
[Bosch, Annet M.] Univ Amsterdam, Acad Med Ctr, Dept Pediat, NL-1105 AZ Amsterdam, Netherlands.
[Enns, Greg] Stanford Univ, Dept Pediat, Palo Alto, CA 94304 USA.
[Wright, Erica L.] Univ Colorado, Med Ctr, Dept Pediat, Denver, CO 80202 USA.
[Owen, Natalie N.] Monroe Carrell Jr Childrens Hosp Vanderbilt, Dept Pediat, Nashville, TN USA.
[Lipson, Mark H.] Kaiser Permanente, Med Genet, Sacramento, CA USA.
[Cerone, Roberto] G Gaslini Inst Children, Univ Dept Pediat, Genoa, Italy.
[Levy, Paul] Childrens Hosp Montefiore, Dept Pediat, Bronx, NY USA.
[Dezsofi, Antal] Semmelweis Univ, Dept Pediat 1, H-1085 Budapest, Hungary.
RP Arnold, GL (reprint author), UPMC, Childrens Hosp Pittsburgh, 4401 Penn Ave,Suite 1200, Pittsburgh, PA 15224 USA.
CR BEEMER FA, 1982, EUR J PEDIATR, V138, P351, DOI 10.1007/BF00442517
Cho SY, 2012, CLIN GENET, V81, P96, DOI 10.1111/j.1399-0004.2011.01704.x
Dantas Maria Fernanda, 2005, Hum Mutat, V26, P164, DOI 10.1002/humu.9352
ELPELEG ON, 1992, J PEDIATR-US, V121, P407, DOI 10.1016/S0022-3476(05)81796-2
Ficicioglu C, 2006, PEDIATRICS, V118, P2555, DOI 10.1542/peds.2006.1659
Gibson KM, 1998, J PEDIATR-US, V132, P519, DOI 10.1016/S0022-3476(98)70032-0
Ihara K, 1997, EUR J PEDIATR, V156, P713, DOI 10.1007/s004310050696
Koeberl DD, 2003, J INHERIT METAB DIS, V26, P25, DOI 10.1023/A:1024015227863
Matern D., MEDIUM CHAIN ACYL CO
MOURMANS J, 1995, J INHERIT METAB DIS, V18, P643, DOI 10.1007/BF02436014
Niu DM, 2010, J INHERIT METAB DIS, V33, pS295, DOI 10.1007/s10545-010-9129-z
PEARSON MA, 1995, J INHERIT METAB DIS, V18, P640, DOI 10.1007/BF02436012
ROSCHINGER W, 1995, CLIN CHIM ACTA, V240, P35, DOI 10.1016/0009-8981(95)06126-2
RUTLEDGE SL, 1995, J INHERIT METAB DIS, V18, P299, DOI 10.1007/BF00710419
Sweetman L, 2001, METABOLIC MOL BASES, V8th, P2125
NR 15
TC 3
Z9 3
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 1096-7192
J9 MOL GENET METAB
JI Mol. Genet. Metab.
PD AUG
PY 2012
VL 106
IS 4
BP 439
EP 441
DI 10.1016/j.ymgme.2012.04.006
PG 3
WC Biochemistry & Molecular Biology; Genetics & Heredity; Medicine,
Research & Experimental
SC Biochemistry & Molecular Biology; Genetics & Heredity; Research &
Experimental Medicine
GA 986DV
UT WOS:000307322100007
PM 22658692
ER
PT J
AU [Anonymous]
AF [Anonymous]
TI Adult autism
SO PSYCHOLOGIST
LA English
DT News Item
NR 0
TC 0
Z9 0
PU BRITISH PSYCHOLOGICAL SOC
PI LEICESTER
PA ST ANDREWS HOUSE, 48 PRINCESS RD EAST, LEICESTER LE1 7DR, LEICS, ENGLAND
SN 0952-8229
J9 PSYCHOLOGIST
JI Psychologist
PD AUG
PY 2012
VL 25
IS 8
BP 572
EP 572
PG 1
WC Psychology, Multidisciplinary
SC Psychology
GA 981PB
UT WOS:000306980200023
ER
PT J
AU Wollner, C
AF Woellner, Clemens
TI Is Empathy Related to the Perception of Emotional Expression in Music? A
Multimodal Time-Series Analysis
SO PSYCHOLOGY OF AESTHETICS CREATIVITY AND THE ARTS
LA English
DT Article
DE cognitive and affective empathy; expressiveness; time-series analysis;
music performance
ID HIGH-FUNCTIONING AUTISM; NORMAL SEX-DIFFERENCES; ASPERGER-SYNDROME;
PERFORMANCE; JUDGMENTS; RESONANCE; COMMUNICATION; PERSPECTIVE;
RESPONSES; QUOTIENT
AB Recent theories of empathy highlight perception-action components as a basis for automatic responses to perceived emotions. Since music is universally based on human actions and often elicits strong emotions, it was hypothesized that empathy influences audiovisual estimations of emotional expression. In this study, the performance and perception of a string quartet was investigated using time-series analyses. Quartet musicians rated video presentations of their own performance, resulting in relationships between visual-only and auditory-only judgments as well as acoustical intensity measures. Independent observers accurately perceived the string quartet's expressive intentions in multimodal presentations. Observers with higher affective and overall empathy were more accurate at estimating the musicians' intentions. It is argued that empathy-via the perception of bodily motion-has an impact on the appreciation of performing arts such as music.
C1 Univ Bremen, D-28359 Bremen, Germany.
RP Wollner, C (reprint author), Univ Bremen, FB 9,Enrique Schmidt Str 7, D-28359 Bremen, Germany.
EM woellner@uni-bremen.de
CR Aglioti SM, 2008, NAT NEUROSCI, V11, P1109, DOI 10.1038/nn.2182
Anderson C, 2002, BEHAV BRAIN SCI, V25, P21
Argyle M., 1988, BODILY COMMUNICATION
Bach P, 2007, COGNITION, V102, P151, DOI 10.1016/j.cognition.2005.11.003
Bachorik JP, 2009, MUSIC PERCEPT, V26, P355, DOI 10.1525/MP.2009.26.4.355
Baron-Cohen S, 2004, J AUTISM DEV DISORD, V34, P163, DOI 10.1023/B:JADD.0000022607.19833.00
Baron-Cohen S, 2003, PHILOS T ROY SOC B, V358, P361, DOI 10.1098/rstb.2002.1206
Batson CD, 2007, J PERS SOC PSYCHOL, V93, P65, DOI 10.1037/0022-3514.93.1.65
Behne KE, 2011, MUSIC SCI, V15, P324, DOI 10.1177/1029864911410955
Blair RJR, 2005, CONSCIOUS COGN, V14, P698, DOI 10.1016/j.concog.2005.06.004
Boersma P., 2010, PRAAT DOING PHONETIC
Brass M, 2001, ACTA PSYCHOL, V106, P3, DOI 10.1016/S0001-6918(00)00024-X
Calvo-Merino B, 2006, CURR BIOL, V16, P1905, DOI 10.1016/j.cub.2006.07.065
Camurri A., 2004, GESTURE BASED COMMUN, P357
Casile A, 2006, CURR BIOL, V16, P69, DOI 10.1016/j.cub.2005.10.071
Curtis ME, 2010, EMOTION, V10, P335, DOI 10.1037/a0017928
Dahl S., 2005, BEAT HUMAN MOVEMENT
Davidson J. W., 2004, MUSICAL EXCELLENCE S, P105
Davidson J. W., 1995, MUSIC MIND MACHINE P, P105, DOI DOI 10.1007/978-3-642-79327-1_11
DAVIS MH, 1983, J PERS SOC PSYCHOL, V44, P113, DOI 10.1037//0022-3514.44.1.113
Decety J, 2010, EMOT REV, V2, P204, DOI 10.1177/1754073910361981
Ekman P, 1997, WHAT FACE REVEALS BA
EYSENCK SBG, 1978, PSYCHOL REP, V43, P1247
Friberg A, 1999, J ACOUST SOC AM, V105, P1469, DOI 10.1121/1.426687
Gallese V., 2005, PHENOMENOLOGY COGNIT, V4, P23, DOI DOI 10.1007/S11097-005-4737-Z
Gallese V, 2001, J CONSCIOUSNESS STUD, V8, P33
Goodman E. C., 2002, MUSICAL PERFORMANCE, P153
Graziano WG, 2007, J PERS SOC PSYCHOL, V93, P583, DOI 10.1037/0022-3514.93.4.583
Greitemeyer T, 2009, PERS SOC PSYCHOL B, V35, P1500, DOI 10.1177/0146167209341648
Gutsell JN, 2010, J EXP SOC PSYCHOL, V46, P841, DOI 10.1016/j.jesp.2010.03.011
Hatfield Elaine, 1994, EMOTIONAL CONTAGION
Heberlein AS, 2004, J COGNITIVE NEUROSCI, V16, P1143, DOI 10.1162/0898929041920423
Hoeckner B, 2011, PSYCHOL AESTHET CREA, V5, P146, DOI 10.1037/a0021544
Hoffman M., 2000, EMPATHY MORAL DEV
HOGAN R, 1969, J CONSULT CLIN PSYCH, V33, P307, DOI 10.1037/h0027580
Jackendoff R, 2006, COGNITION, V100, P33, DOI 10.1016/j.cognition.2005.11.005
JEANNEROD M, 1994, BEHAV BRAIN SCI, V17, P187
Juslin P. N., 2010, HDB MUSIC EMOTION
Juslin PN, 2008, BEHAV BRAIN SCI, V31, P559, DOI 10.1017/S0140525X08005293
Juslin PN, 2003, PSYCHOL BULL, V129, P770, DOI 10.1037/0033-2909.129.5.770
Knoblich G, 2001, PSYCHOL SCI, V12, P467, DOI 10.1111/1467-9280.00387
Lamm C, 2007, J COGNITIVE NEUROSCI, V19, P42, DOI 10.1162/jocn.2007.19.1.42
Lamm C, 2010, J COGNITIVE NEUROSCI, V22, P362, DOI 10.1162/jocn.2009.21186
Lipps T., 1903, ASTHETIK PSYCHOL SCH
McAdams S, 2004, MUSIC PERCEPT, V22, P297, DOI 10.1525/mp.2004.22.2.297
MEHRABIA.A, 1972, J PERS, V40, P525, DOI 10.1111/j.1467-6494.1972.tb00078.x
Mitchell RW, 2001, MUSIC PERCEPT, V19, P65, DOI 10.1525/mp.2001.19.1.65
Newman-Norlund SE, 2009, COGNITION, V111, P46, DOI 10.1016/j.cognition.2008.12.004
North A. C., 2008, SOCIAL APPL PSYCHOL
OCONNELL SM, 1995, PRIMATES, V36, P397, DOI 10.1007/BF02382862
Panksepp J, 2011, SCIENCE, V334, P1358, DOI 10.1126/science.1216480
Preston SD, 2002, BEHAV BRAIN SCI, V25, P1
Prinz W, 1997, EUR J COGN PSYCHOL, V9, P129, DOI 10.1080/713752551
Reniers RLEP, 2011, J PERS ASSESS, V93, P84, DOI 10.1080/00223891.2010.528484
Rizzolatti G, 2004, ANNU REV NEUROSCI, V27, P169, DOI 10.1146/annurev.neuro.27.070203.144230
Scherer K. R., 2001, MUSIC EMOTION THEORY, P361
Schubert E, 2004, MUSIC PERCEPT, V21, P561, DOI 10.1525/mp.2004.21.4.561
Schutz-Bosbach S, 2007, TRENDS COGN SCI, V11, P349, DOI 10.1016/j.tics.2007.06.005
Sevdalis V, 2011, PSYCHOL RES-PSYCH FO, V75, P423, DOI 10.1007/s00426-010-0312-5
Singer T, 2006, NATURE, V439, P466, DOI 10.1038/nature04271
Tipper SP, 2008, J EXP SOC PSYCHOL, V44, P1082, DOI 10.1016/j.jesp.2007.11.005
Vines BW, 2006, COGNITION, V101, P80, DOI 10.1016/j.cognition.2005.09.003
Vischer Robert, 1994, EMPATHY FORM SPACE P
Wollner C, 2010, PSYCHOL RES-PSYCH FO, V74, P579, DOI 10.1007/s00426-010-0280-9
Wollner C, 2008, MUSIC SCI, V12, P249
NR 65
TC 2
Z9 2
PU EDUCATIONAL PUBLISHING FOUNDATION-AMERICAN PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST, NE, WASHINGTON, DC 20002-4242 USA
SN 1931-3896
J9 PSYCHOL AESTHET CREA
JI Psychol. Aesthet. Creat. Arts.
PD AUG
PY 2012
VL 6
IS 3
BP 214
EP 223
DI 10.1037/a0027392
PG 10
WC Humanities, Multidisciplinary; Psychology, Experimental
SC Arts & Humanities - Other Topics; Psychology
GA 987OW
UT WOS:000307428000004
ER
PT J
AU Bracher, M
AF Bracher, Mike
TI Autism and Representation
SO SOCIOLOGY-THE JOURNAL OF THE BRITISH SOCIOLOGICAL ASSOCIATION
LA English
DT Book Review
C1 [Bracher, Mike] Univ Southampton, Sch Social Sci, Southampton SO17 1BJ, Hants, England.
RP Bracher, M (reprint author), Univ Southampton, Sch Social Sci, Southampton SO17 1BJ, Hants, England.
EM mb5v07@soton.ac.uk
CR Osteen M, 2008, ROUTL RES CULT MEDIA, P1
NR 1
TC 0
Z9 0
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0038-0385
J9 SOCIOLOGY
JI Sociol.-J. Brit. Sociol. Assoc.
PD AUG
PY 2012
VL 46
IS 4
BP 759
EP 766
PG 8
WC Sociology
SC Sociology
GA 987WN
UT WOS:000307448700015
ER
PT J
AU Bracher, M
AF Bracher, Mike
TI Autism and the Edges of the Known World: Language, Sensitivities and
Constructed Reality
SO SOCIOLOGY-THE JOURNAL OF THE BRITISH SOCIOLOGICAL ASSOCIATION
LA English
DT Book Review
C1 [Bracher, Mike] Univ Southampton, Sch Social Sci, Southampton SO17 1BJ, Hants, England.
RP Bracher, M (reprint author), Univ Southampton, Sch Social Sci, Southampton SO17 1BJ, Hants, England.
EM mb5v07@soton.ac.uk
CR Bogdashina O., 2010, AUTISM EDGES KNOWN W
NR 1
TC 0
Z9 0
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0038-0385
J9 SOCIOLOGY
JI Sociol.-J. Brit. Sociol. Assoc.
PD AUG
PY 2012
VL 46
IS 4
BP 759
EP 766
PG 8
WC Sociology
SC Sociology
GA 987WN
UT WOS:000307448700014
ER
PT J
AU Bracher, M
AF Bracher, Mike
TI Unstrange Minds: A Father Remaps the World of Autism
SO SOCIOLOGY-THE JOURNAL OF THE BRITISH SOCIOLOGICAL ASSOCIATION
LA English
DT Book Review
C1 [Bracher, Mike] Univ Southampton, Sch Social Sci, Southampton SO17 1BJ, Hants, England.
RP Bracher, M (reprint author), Univ Southampton, Sch Social Sci, Southampton SO17 1BJ, Hants, England.
EM mb5v07@soton.ac.uk
CR Grinker R., 2008, UNSTRANGE MINDS FATH
NR 1
TC 0
Z9 0
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0038-0385
J9 SOCIOLOGY
JI Sociol.-J. Brit. Sociol. Assoc.
PD AUG
PY 2012
VL 46
IS 4
BP 759
EP 766
PG 8
WC Sociology
SC Sociology
GA 987WN
UT WOS:000307448700013
ER
PT J
AU Fisher, B
Dezort, C
Nordli, DR
Berg, AT
AF Fisher, Breanne
Dezort, Catherine
Nordli, Douglas R.
Berg, Anne T.
TI Routine developmental and autism screening in an epilepsy care setting
SO EPILEPSY & BEHAVIOR
LA English
DT Article
DE Epilepsy; Children; Developmental delay; Autism; Screening;
Co-morbidities; Comprehensive epilepsy care
ID EPILEPTIFORM EEG ABNORMALITIES; CHILDHOOD-ONSET EPILEPSY; SPECTRUM
DISORDERS; CRYPTOGENIC EPILEPSY; MODIFIED CHECKLIST; CHILDREN; SEIZURES;
TODDLERS; AGE
AB Developmental delay (delay) and co-morbidities like autism are common in children with epilepsy. We assessed the yield of routine screening for delay and autism in a hospital-based program.
Parents completed developmental and autism screeners for 65 children (average age = 2.5 y; 38(58%) boys). Forty-nine (75%) were established epilepsy patients, and 16 (25%) were new patients.
For development, 47 (72%) children screened positive and 8 (12%) had borderline results. Twenty-four (37%) scored positive for autism, all of whom also screened positive for developmental delay. Delays and neurologic deficits accounted for the positive autism results in 20 of the 24.
Developmental findings were confirmatory (already receiving services) in 32/55 (58%) children and actionable in 17 (31%) (requiring further evaluation).
Referrals for further evaluations were made for most with actionable findings. The yield of routine screening of children in a tertiary center is sufficiently high to support its use and to consider screening of all children seen with epilepsy. (C) 2012 Elsevier Inc. All rights reserved.
C1 [Fisher, Breanne; Dezort, Catherine; Nordli, Douglas R.; Berg, Anne T.] Ann & Robert H Lurie Childrens Hosp Chicago, Epilepsy Ctr, Chicago, IL 60611 USA.
[Nordli, Douglas R.; Berg, Anne T.] NW Univ Feinberg, Sch Med, Dept Pediat, Chicago, IL USA.
RP Berg, AT (reprint author), Ann & Robert H Lurie Childrens Hosp Chicago, Epilepsy Ctr, 225 E Chicago Ave,Box 29, Chicago, IL 60611 USA.
EM atberg@luriechildrens.org
FU Shaw Research Grants in Nursing and Allied Health Professions
FX This study was funded by the Shaw Research Grants in Nursing and Allied
Health Professions (B. Fisher and C. Dezort).
CR American Academy of Pediatrics, 2001, PEDIATRICS, V108, P192, DOI DOI 10.1542/PEDS.108.1.192
Amiet C, 2008, BIOL PSYCHIAT, V64, P577, DOI 10.1016/j.biopsych.2008.04.030
Austin JK, 2001, PEDIATRICS, V107, P115, DOI 10.1542/peds.107.1.115
Berg AT, 2008, EPILEPSY BEHAV, V13, P614, DOI 10.1016/j.yebeh.2008.07.007
Berg AT, 2008, EPILEPSIA, V49, P608, DOI 10.1111/j.1528-1167.2007.01461.x
Berg AT, 2012, EPILEPSY BEHAV, V23, P193, DOI 10.1016/j.yebeh.2012.01.015
Berg AT, 2011, EPILEPSY BEHAV, V22, P336, DOI 10.1016/j.yebeh.2011.07.014
Besag FMC, 2009, ACTA PAEDIATR, V98, P618, DOI 10.1111/j.1651-2227.2008.01190.x
Brooks-Kayal A, 2010, BRAIN DEV-JPN, V32, P731, DOI 10.1016/j.braindev.2010.04.010
Burton K, 2011, DEV MED CHILD NEUROL, V53, P1135, DOI 10.1111/j.1469-8749.2011.04109.x
Camfield C, 2007, PEDIATRICS, V120, pE52, DOI 10.1542/peds.2006.3290
Chandler S, 2007, J AM ACAD CHILD PSY, V46, P1324, DOI 10.1097/chi.0b013e31812f7d8d
Chez MG, 2006, EPILEPSY BEHAV, V8, P267, DOI 10.1016/j.yebeh.2005.11.001
ELLENBERG JH, 1984, ANN NEUROL, V15, P127, DOI 10.1002/ana.410150204
England MJ, 2012, EPILEPSY SPECTRUM PR
Filipek PA, 2000, NEUROLOGY, V55, P468
Geerts A, 2011, EPILEPSIA, V52, P2192, DOI 10.1111/j.1528-1167.2011.03294.x
Hermann B, 2006, BRAIN, V129, P2609, DOI 10.1093/brain/awl196
Hermann BP, 2008, EPILEPSIA, V49, P1847, DOI 10.1111/j.1528-1167.2008.01735.x
Kim HL, 2006, EPILEPSIA, V47, P394, DOI 10.1111/j.1528-1167.2006.00434.x
Levisohn PM, 2007, EPILEPSIA, V48, P33, DOI 10.1111/j.1528-1167.2007.01399.x
Luyster RJ, 2011, PAEDIATR PERINAT EP, V25, P366, DOI 10.1111/j.1365-3016.2010.01187.x
Nordli DR, 2007, EPILEPSIA, V48, P206
Oostrom KJ, 2003, EPILEPSIA, V44, P97, DOI 10.1046/j.1528-1157.2003.18202.x
PANAYIOTOPOULOS CP, 1993, J NEUROL NEUROSUR PS, V56, P2, DOI 10.1136/jnnp.56.1.2
Pierce K, 2011, J PEDIATR-US, V159, P458, DOI 10.1016/j.jpeds.2011.02.036
Robins DL, 2001, J AUTISM DEV DISORD, V31, P131, DOI 10.1023/A:1010738829569
Saemundsen E, 2007, EPILEPSIA, V48, P1724, DOI 10.1111/j.1528-1167.2007.01150.x
Spence SJ, 2009, PEDIATR RES, V65, P599, DOI 10.1203/PDR.0b013e31819e7168
Squires J, 1997, J PEDIATR PSYCHOL, V22, P313, DOI 10.1093/jpepsy/22.3.313
TUCHMAN RF, 1991, PEDIATRICS, V88, P1219
Yasuhara A, 2010, BRAIN DEV-JPN, V32, P791, DOI 10.1016/j.braindev.2010.08.010
NR 32
TC 5
Z9 5
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 1525-5050
J9 EPILEPSY BEHAV
JI Epilepsy Behav.
PD AUG
PY 2012
VL 24
IS 4
BP 488
EP 492
DI 10.1016/j.yebeh.2012.06.006
PG 5
WC Behavioral Sciences; Clinical Neurology; Psychiatry
SC Behavioral Sciences; Neurosciences & Neurology; Psychiatry
GA 980NO
UT WOS:000306900300018
PM 22789633
ER
PT J
AU Kully-Martens, K
Pei, J
Job, J
Rasmussen, C
AF Kully-Martens, Katrina
Pei, Jacqueline
Job, Jenelle
Rasmussen, Carmen
TI Source Monitoring in Children With and Without Fetal Alcohol Spectrum
Disorders
SO JOURNAL OF PEDIATRIC PSYCHOLOGY
LA English
DT Article
DE cognitive development; FASD; memory; prenatal alcohol exposure; source
monitoring
ID MEMORY; EXPOSURE; SCHIZOPHRENIA; FEATURES; AUTISM
AB Objectives Deficits in memory are well-documented in children with fetal alcohol spectrum disorders (FASD); however, one aspect of memory not yet studied in children with FASD is source monitoring. This study examined overall source monitoring ability and performance profiles of children with FASD compared to controls. Method Participants included 19 children with FASD and 38 typically developing children (aged 6-12 years). Children were presented with auditory word lists and were required to recall the source of words for reality, external, and internal source monitoring tasks. Results Children with FASD showed poorer performance than controls across all three conditions in both recognition memory and memory for source. However, both groups exhibited a comparable pattern of performance across conditions. Specifically, performance was lowest on the internal task and highest on the reality task. Conclusions Information about source monitoring deficits further delineates the intricacies of memory deficits in FASD, and has implications for both assessment and intervention.
C1 [Kully-Martens, Katrina; Rasmussen, Carmen] Univ Alberta, Dept Pediat, Edmonton, AB T6G 2M7, Canada.
[Pei, Jacqueline; Job, Jenelle] Univ Alberta, Dept Educ Psychol, Edmonton, AB T6G 2M7, Canada.
RP Rasmussen, C (reprint author), Glenrose Rehabil Hosp, E213C,10230-111 Ave, Edmonton, AB T5G 0B7, Canada.
EM carmen@ualberta.ca
CR Astley S. J., 2004, DIAGNOSTIC GUIDE FET
Bishop S, 2007, J CHILD PSYCHOL PSYC, V48, P1111, DOI 10.1111/j.1469-7610.2007.01782.x
Chudley AE, 2005, CAN MED ASSOC J, V172, pS1, DOI 10.1503/cmaj.1040302
Ditman T, 2005, HARVARD REV PSYCHIAT, V13, P280, DOI 10.1080/10673220500326391
Farrant A, 1998, J AUTISM DEV DISORD, V28, P359
Fenson L., 1994, VARIABILITY EARLY CO
FOLEY MA, 1983, CHILD DEV, V54, P51, DOI 10.1111/j.1467-8624.1983.tb00332.x
Glisky EL, 2008, J EXP PSYCHOL LEARN, V34, P809, DOI 10.1037/0278-7393.34.4.809
Hala S, 2005, J AUTISM DEV DISORD, V35, P75, DOI 10.1007/s10803-004-1036-4
JOHNSON MK, 1993, PSYCHOL BULL, V114, P3, DOI 10.1037//0033-2909.114.1.3
Kodituwakku PW, 1995, ALCOHOL CLIN EXP RES, V19, P1558, DOI 10.1111/j.1530-0277.1995.tb01024.x
Kodituwakku PW, 2009, DEV DISABIL RES REV, V15, P218, DOI 10.1002/ddrr.73
Laugeson EA, 2007, CHILD FAM BEHAV THER, V29, P57, DOI 10.1300/J019v29n03_04
LINDSAY DS, 1991, B PSYCHONOMIC SOC, V29, P203
Lorsbach T., 1995, INT J DISABILITY DEV, V42, P241, DOI 10.1080/0156655950420306
Lorsbach T., 1991, LEARNING INDIVIDUAL, V3, P135, DOI 10.1016/1041-6080(91)90013-Q
Lupton C, 2004, AM J MED GENET C, V127C, P42, DOI 10.1002/ajmg.c.30015
MANJI S, 2010, DEV NEUROREHABIL, V12, P239
Marrimarella N, 2008, EUR J COGN PSYCHOL, V20, P91, DOI 10.1080/09541440601112522
Mattson SN, 2002, ALCOHOL CLIN EXP RES, V26, P875, DOI 10.1111/j.1530-0277.2002.tb02617.x
Mattson SN, 1998, NEUROPSYCHOLOGY, V12, P146, DOI 10.1037//0894-4105.12.1.146
Pei J. R., 2008, CAN J CLIN PHARM, V15, P44
Rasmussen C, 2005, ALCOHOL CLIN EXP RES, V29, P1359, DOI 10.1097/01.alc.0000175040.91007.d0
Ryan R., 2010, N AM J PSYCHOL, V12, P410
RYBASH JM, 1994, DEV NEUROPSYCHOL, V10, P67
Stade B., 2006, J FAS INT, V4, P1
Startup M, 2008, BEHAV RES THER, V46, P1176, DOI 10.1016/j.brat.2008.07.003
Streissguth A, 2007, J CLIN PSYCHOL MED S, V14, P81, DOI 10.1007/s10880-007-9067-6
Streissguth AP, 1997, FETAL ALCOHOL SYNDRO
Thanh N., 2009, CANADIAN J CLIN PHAR, V16, P80
Willford JA, 2004, ALCOHOL CLIN EXP RES, V28, P497, DOI 10.1097/01.ALC.0000117868.97486.2D
NR 31
TC 1
Z9 1
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0146-8693
J9 J PEDIATR PSYCHOL
JI J. Pediatr. Psychol.
PD AUG
PY 2012
VL 37
IS 7
BP 725
EP 735
DI 10.1093/jpepsy/jsr123
PG 11
WC Psychology, Developmental
SC Psychology
GA 981KC
UT WOS:000306965500003
PM 22381645
ER
PT J
AU Constantino, JN
Charman, T
AF Constantino, John N.
Charman, Tony
TI Gender Bias, Female Resilience, and the Sex Ratio in Autism
SO JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
LA English
DT Editorial Material
C1 [Constantino, John N.] Washington Univ, St Louis, MO 63130 USA.
[Charman, Tony] Inst Educ, Ctr Res Autism & Educ, London, England.
RP Constantino, JN (reprint author), 660 S Euclid,Campus Box 8134, St Louis, MO 63110 USA.
EM constantino@wustl.edu
RI Charman, Tony/A-2085-2014
OI Charman, Tony/0000-0003-1993-6549
CR Charman T, 2013, CHILD ADOL MENT H-UK, V18, P52, DOI 10.1111/j.1475-3588.2012.00664.x
Constantino JN, 2011, PEDIATR RES, V69, p55R, DOI 10.1203/PDR.0b013e318212ec6e
Constantino JN, 2010, AM J PSYCHIAT, V167, P1349, DOI 10.1176/appi.ajp.2010.09101470
Constantino JN, 2013, MOL PSYCHIATR, V18, P137, DOI 10.1038/mp.2012.9
Dworzynski K, 2012, J AM ACAD CHILD PSY, V51, P788, DOI 10.1016/j.jaac.2012.05.018
Giarelli E, 2010, DISABIL HEALTH J, V3, P107, DOI 10.1016/j.dhjo.2009.07.001
Goin-Kochel RP, 2007, AUTISM, V11, P279, DOI 10.1177/1362361307076857
Hall SS, 2010, J AM ACAD CHILD PSY, V49, P921, DOI 10.1016/j.jaac.2010.07.001
Russell G, 2011, SOC PSYCH PSYCH EPID, V46, P1283, DOI 10.1007/s00127-010-0294-z
Sato D, 2012, AM J HUM GENET, V90, P879, DOI 10.1016/j.ajhg.2012.03.017
Virkud YV, 2009, AM J MED GENET B, V150B, P328, DOI 10.1002/ajmg.b.30810
NR 11
TC 12
Z9 12
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0890-8567
J9 J AM ACAD CHILD PSY
JI J. Am. Acad. Child Adolesc. Psychiatr.
PD AUG
PY 2012
VL 51
IS 8
BP 756
EP 758
DI 10.1016/j.jaac.2012.05.017
PG 3
WC Psychology, Developmental; Pediatrics; Psychiatry
SC Psychology; Pediatrics; Psychiatry
GA 983OJ
UT WOS:000307128300002
PM 22840545
ER
PT J
AU Kataoka, SH
AF Kataoka, Sheryl H.
TI Fixing a Broken System: The Story of Autism, One State at a Time
SO JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
LA English
DT Editorial Material
C1 Univ Calif Los Angeles, Ctr Hlth Serv & Soc, Semel Inst Neurosci & Human Behav, Los Angeles, CA 90024 USA.
RP Kataoka, SH (reprint author), Univ Calif Los Angeles, Ctr Hlth Serv & Soc, Semel Inst Neurosci & Human Behav, 10920 Wilshire Blvd,Suite 300, Los Angeles, CA 90024 USA.
EM skataoka@mednet.ucla.edu
CR Centers for Medicare and Medicaid Services (CMS) ASD Services Project, 2011, REP STAT SERV IND AU
Child and Adolescent Health Measurement Initiative, 2012, NAT PROF CHILDR SPEC
Dawson G, 2010, PEDIATRICS, V125, pE17, DOI 10.1542/peds.2009-0958
Fritz GK, 2012, J AM ACAD CHILD PSY, V51, P458, DOI 10.1016/j.jaac.2012.02.003
Kasari C, 2012, J AM ACAD CHILD PSY, V51, P487, DOI 10.1016/j.jaac.2012.02.019
National Conference of State Legislatures, INS COV AUT NAT C ST
Stein BD, 2012, J AM ACAD CHILD PSY, V51, P771, DOI 10.1016/j.jaac.2012.06.006
Young Margaret B., 2012, Morbidity and Mortality Weekly Report, V61, P1
United States Government Accountability Office, 2005, SPEC ED CHILDR AUT
NR 9
TC 2
Z9 2
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0890-8567
J9 J AM ACAD CHILD PSY
JI J. Am. Acad. Child Adolesc. Psychiatr.
PD AUG
PY 2012
VL 51
IS 8
BP 759
EP 761
DI 10.1016/j.jaac.2012.06.009
PG 3
WC Psychology, Developmental; Pediatrics; Psychiatry
SC Psychology; Pediatrics; Psychiatry
GA 983OJ
UT WOS:000307128300003
PM 22840546
ER
PT J
AU Stein, BD
Sorbero, MJ
Goswami, U
Schuster, J
Leslie, DL
AF Stein, Bradley D.
Sorbero, Mark J.
Goswami, Upasna
Schuster, James
Leslie, Douglas L.
TI Impact of a Private Health Insurance Mandate on Public Sector Autism
Service Use in Pennsylvania
SO JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
LA English
DT Article
DE autism; policy; services; medications; treatment costs
ID BEHAVIORAL TREATMENT; SPECTRUM DISORDERS; YOUNG-CHILDREN; INTERVENTION;
MEDICAID; COVERAGE
AB Objective: Many states have implemented regulations (commonly referred to as waivers) to increase access to publicly insured services for autism spectrum disorders (ASD). In recent years, several states have passed legislation requiring improved coverage for ASD services by private insurers. This study examines the impact of such legislation on use of Medicaid-funded ASD services. Method: We used Medicaid claims data from July 1, 2006, through June 30, 2010, to identify children with ASD and to assess their use of behavioral health services and psychotropic medications. Service and medication use were examined in four consecutive 12-month periods: the 2 years preceding passage of the legislation, the year after passage but before implementation, and the year after implementation. We examined differences in use of services and medications, and used growth rates from nonwaiver children to estimate the impact of the legislation on Medicaid spending for waiver-eligible children with ASD. Results: The number of children with ASD receiving Medicaid services increased 20% from 2006-2007 to 2009-2010. The growth rate among children affected by the legislation was comparable to that of other groups before passage of the legislation but decreased after the legislation's passage. We project that, without the legislation, growth in this population would have been 46% greater in 2009-2010 than observed, associated with spending of more than $8 million in 2009-2010. Conclusions: Passage of legislation increasing private insurance coverage of ASD services may decrease the number of families seeking eligibility to obtain Medicaid-funded services, with an associated substantial decrease in Medicaid expenditures. J. Am. Acad. Child Adolesc. Psychiatry, 2012;51(8):771-779.
C1 [Stein, Bradley D.; Goswami, Upasna] Univ Pittsburgh, Pittsburgh, PA 15260 USA.
[Leslie, Douglas L.] Penn State Univ, Coll Med, University Pk, PA 16802 USA.
RP Stein, BD (reprint author), RAND Corp, 4570 5th Ave,Suite 600, Pittsburgh, PA 15213 USA.
FU Community Core Behavioral Health Organization
FX This work was supported by the Community Core Behavioral Health
Organization.
CR Bouder JN, 2009, J AUTISM DEV DISORD, V39, P953, DOI 10.1007/s10803-009-0701-z
Centers for Disease Control and Prevention (CDC), 2012, AUT DEV DIS MON ADDM
Cohen H, 2006, J DEV BEHAV PEDIATR, V27, pS145, DOI 10.1097/00004703-200604002-00013
Commonwealth of Pennsylvania, 2003, PENNS STAT PLAN TITL, p1e
Dawson G, 2010, PEDIATRICS, V125, pE17, DOI 10.1542/peds.2009-0958
Halfon N, 2001, PED AC SOC M APR 28
Harris SL, 2000, J AUTISM DEV DISORD, V30, P137, DOI 10.1023/A:1005459606120
Ku L, 2010, HEALTH AFFAIR, V29, P1173, DOI 10.1377/hlthaff.2010.0417
LOVAAS OI, 1987, J CONSULT CLIN PSYCH, V55, P3, DOI 10.1037/0022-006X.55.1.3
Mandell DS, 2006, J AUTISM DEV DISORD, V36, P475, DOI 10.1007/s10803-006-0088-z
Peele PB, 2002, PSYCHIATR SERV, V53, P591, DOI 10.1176/appi.ps.53.5.591
Remington B, 2007, AM J MENT RETARD, V112, P418, DOI 10.1352/0895-8017(2007)112[418:EIBIOF]2.0.CO;2
Shattuck PT, 2007, MENT RETARD DEV D R, V13, P129, DOI 10.1002/mrdd.20143
Smith T, 2000, AM J MENT RETARD, V105, P269, DOI 10.1352/0895-8017(2000)105<0269:RTOIEI>2.0.CO;2
Spigel S., 2007, MED AUTISM WAIVERS S
Stahmer AC, 2007, ADM POLICY MENT HLTH, V34, P29, DOI 10.1007/s10488-006-0060-4
Thomas KC, 2012, MATERN CHILD HLTH J, V16, P1636, DOI 10.1007/s10995-011-0862-1
NR 17
TC 3
Z9 3
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0890-8567
J9 J AM ACAD CHILD PSY
JI J. Am. Acad. Child Adolesc. Psychiatr.
PD AUG
PY 2012
VL 51
IS 8
BP 771
EP 779
DI 10.1016/j.jaac.2012.06.006
PG 9
WC Psychology, Developmental; Pediatrics; Psychiatry
SC Psychology; Pediatrics; Psychiatry
GA 983OJ
UT WOS:000307128300005
PM 22840548
ER
PT J
AU Dworzynski, K
Ronald, A
Bolton, P
Happe, F
AF Dworzynski, Katharina
Ronald, Angelica
Bolton, Patrick
Happe, Francesca
TI How Different Are Girls and Boys Above and Below the Diagnostic
Threshold for Autism Spectrum Disorders?
SO JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
LA English
DT Article
DE autism spectrum disorder; gender differences; girls/females; diagnosis;
autistic traits
ID CAST CHILDHOOD ASPERGER; TWINS EARLY DEVELOPMENT; DIFFICULTIES
QUESTIONNAIRE; INDIVIDUAL-DIFFERENCES; GENERAL-POPULATION; BEHAVIOR
PROBLEMS; SEX-DIFFERENCES; LANGUAGE; TRAITS; EPIDEMIOLOGY
AB Objective: This study aimed to explore sex differences in autistic traits in relation to diagnosis, to elucidate factors that might differentially impact whether girls versus boys meet diagnostic criteria for autism or a related autism spectrum disorder (ASD). Method: Data from a large population-based sample of children were examined. Girls and boys (aged 10-12 years) meeting diagnostic criteria for an ASD were compared with those failing to meet diagnostic criteria despite very high scores on a trait measure of ASD, the Childhood Autism Spectrum Test (CAST). information about behavioral difficulties as reported by teachers, and early estimates of intellectual functioning, were compared. Results: Girls, but not boys, meeting diagnostic criteria for ASD showed significantly more additional problems (low intellectual level, behavioral difficulties) than peers with similarly high CAST scores who did not meet diagnostic criteria. Conclusions: These data suggest that, in the absence of additional intellectual or behavioral problems, girls are less likely than boys to meet diagnostic criteria for ASD at equivalently high levels of autistic-like traits. This might reflect gender bias in diagnosis or genuinely better adaptation/compensation in girls. J. Am. Acad. Child Adolesc. Psychiatry, 2012;51(8):788-797.
C1 [Dworzynski, Katharina] Royal Coll Physicians, Natl Clin Guideline Ctr, London, England.
[Ronald, Angelica] Univ London, Genes Environm Lifespan GEL Lab, Ctr Brain & Cognit Dev, London WC1E 7HU, England.
[Bolton, Patrick; Happe, Francesca] Kings Coll London, Inst Psychiat, Med Res Council Social Genet & Dev Psychiat MRC S, London, England.
RP Happe, F (reprint author), Inst Psychiat PO80, MRC SGDP Ctr, DeCrespigny Pk, Denmark Hill, London SE5 8AF, England.
EM francesca.happe@kcl.ac.uk
RI Ronald, Angelica/C-7812-2009; Bolton, Patrick/E-8501-2010
OI Ronald, Angelica/0000-0002-9576-2176; Bolton,
Patrick/0000-0002-5270-6262
FU MRC [G0500079, G0500870]; Autism Speaks fellowship; National Institutes
of Health (NIH)
FX The Twins Early Development Study (TEDS) is funded by an MRC program
grant G0500079. This work was also supported by MRC program grant
G0500870 (F.H., P.B.), an Autism Speaks fellowship (K.D., A.R.), and a
National Institutes of Health (NIH) Research Senior Investigator Award
(P.B.).
CR Baron-Cohen S, 2011, PLOS BIOL, V9, DOI 10.1371/journal.pbio.1001081
Cohen J., 1988, STAT POWER ANAL BEHA, V2nd
Constantino JN, 2010, AM J PSYCHIAT, V167, P1349, DOI 10.1176/appi.ajp.2010.09101470
Dale PS, 1998, NAT NEUROSCI, V1, P324
Dworzynski K, 2009, J AUTISM DEV DISORD, V39, P1197, DOI 10.1007/s10803-009-0736-1
Fombonne E, 2009, PEDIATR RES, V65, P591, DOI 10.1203/PDR.0b013e31819e7203
Goodman R, 2000, J CHILD PSYCHOL PSYC, V41, P645, DOI 10.1111/j.1469-7610.2000.tb02345.x
Goodman R, 1998, EUR CHILD ADOLES PSY, V7, P125
Goodman R, 1997, J CHILD PSYCHOL PSYC, V38, P581, DOI 10.1111/j.1469-7610.1997.tb01545.x
Gould J, 2009, OBSERVER
Lai MC, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0020835
LORD C, 1982, J AUTISM DEV DISORD, V12, P317, DOI 10.1007/BF01538320
Mandy W, 2012, J AUTISM DEV DISORD, V42, P1304, DOI 10.1007/s10803-011-1356-0
Oliver BR, 2007, TWIN RES HUM GENET, V10, P96, DOI 10.1375/twin.10.1.96
Rivet TT, 2011, RES AUTISM SPECT DIS, V5, P957, DOI 10.1016/j.rasd.2010.12.003
Rivet TT, 2011, J DEV PHYS DISABIL, V23, P399, DOI 10.1007/s10882-011-9235-3
Robinson EB, 2011, ARCH GEN PSYCHIAT, V68, P1113, DOI 10.1001/archgenpsychiatry.2011.119
Ronald A, 2005, DEVELOPMENTAL SCI, V8, P444, DOI 10.1111/j.1467-7687.2005.00433.x
Ronald A, 2006, J AM ACAD CHILD PSY, V45, P1206, DOI 10.1097/01.chi.0000230165.54117.41
Ronald A, 2006, J AM ACAD CHILD PSY, V45, P691, DOI 10.1097/01.chi.0000215325.13058.9d
Ronald A, 2006, SOC NEUROSCI-UK, V1, P412, DOI 10.1080/17470910601068088
Russell G, 2011, SOC PSYCH PSYCH EPID, V46, P1283, DOI 10.1007/s00127-010-0294-z
Scott FJ, 2002, AUTISM, V6, P9, DOI 10.1177/1362361302006001003
Szatmari P, 2012, AM J MED GENET B, V159B, P5, DOI 10.1002/ajmg.b.31238
Trouton A, 2002, TWIN RES, V5, P444, DOI 10.1375/136905202320906255
Williams J, 2005, AUTISM, V9, P45, DOI 10.1177/136261305049029
NR 26
TC 43
Z9 45
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0890-8567
J9 J AM ACAD CHILD PSY
JI J. Am. Acad. Child Adolesc. Psychiatr.
PD AUG
PY 2012
VL 51
IS 8
BP 788
EP 797
DI 10.1016/j.jaac.2012.05.018
PG 10
WC Psychology, Developmental; Pediatrics; Psychiatry
SC Psychology; Pediatrics; Psychiatry
GA 983OJ
UT WOS:000307128300007
PM 22840550
ER
PT J
AU Schulte-Ruther, M
Mainz, V
Fink, GR
Herpertz-Dahlmann, B
Konrad, K
AF Schulte-Ruether, Martin
Mainz, Verena
Fink, Gereon R.
Herpertz-Dahlmann, Beate
Konrad, Kerstin
TI Theory of Mind and the Brain in Anorexia Nervosa: Relation to Treatment
Outcome
SO JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
LA English
DT Article
DE anorexia nervosa; superior temporal cortex; social cognition; medial
prefrontal cortex; theory of mind
ID EATING-DISORDERS; SOCIAL ATTRIBUTION; ASPERGER-SYNDROME;
BULIMIA-NERVOSA; AUTISM; COGNITION; ADOLESCENTS; COMORBIDITY;
PREDICTORS; MECHANISMS
AB Converging evidence suggests deficits in theory-of-mind (ToM) processing in patients with anorexia nervosa (AN). The present study aimed at elucidating the neural mechanisms underlying ToM-deficits in AN. Method: A total of 19 adolescent patients with AN and 21 age-matched controls were investigated using functional magnetic resonance imaging during performance of a ToM-task at two time points (in-patients: admission to hospital and discharge after weight recovery). Clinical outcomes in patients were determined 1 year after admission. Results: Irrespective of the time point, AN patients showed reduced activation in middle and anterior temporal cortex and in the medial prefrontal cortex. Hypoactivation in the medial prefrontal cortex at admission to hospital (T1) was correlated with clinical outcome at follow-up. Conclusions: Hypoactivation in the brain network supporting theory of mind may be associated with a social-cognitive endophenotype reflecting impairments of social functioning in anorexia nervosa which is predictive for a poor outcome at 1-year follow-up. J. Am. Acad. Child Adolesc. Psychiatry, 2012;51(8): 832-841.
C1 [Schulte-Ruether, Martin] Res Ctr Julich, Inst Neurosci & Med INM 3, D-52425 Julich, Germany.
[Schulte-Ruether, Martin] Univ Hosp Aachen UKA, Aachen, Germany.
[Mainz, Verena; Fink, Gereon R.; Konrad, Kerstin] Res Ctr Julich, INM 3, D-52425 Julich, Germany.
[Fink, Gereon R.] Univ Hosp Cologne, Cologne, Germany.
[Herpertz-Dahlmann, Beate; Konrad, Kerstin] JARA Translat Brain Res, Julich, Germany.
RP Schulte-Ruther, M (reprint author), Res Ctr Julich, Inst Neurosci & Med INM 3, D-52425 Julich, Germany.
EM mschulte@ukaachen.de
RI Schulte-Ruther, Martin /F-4784-2013; Konrad, Kerstin/H-7747-2013; Fink,
Gereon/E-1616-2012
OI Schulte-Ruther, Martin /0000-0002-7198-9923; Konrad,
Kerstin/0000-0001-9039-2615; Fink, Gereon/0000-0002-8230-1856
FU Bundesministerium fur Bildung und Forschung [BMBF 01GV0602];
Bundesministerium fur Bildung und Forschung; Deutsche
Forschungsgemeinschaft; Vifor; Eli Lilly and Co.; Novartis; Medice
FX This study was supported by the Bundesministerium fur Bildung und
Forschung grant BMBF 01GV0602 (B.H.-D., K.K.).Dr. Fink has served as an
editorial board member of Cortex, Zeitschrift fur Neuropsychologie and
Fortschritte der Neurologie Psychiatrie. He has received royalties from
the publication of the book 'Funktionelle MRT in Psychiotrie und
Neurologie" and "Neurologische Differentialdiagnose," has received
honoraria for speaking engagements from Teva, GlaxoSmithKline, and
Boehringer Ingelheim, and has received research support from the
Bundesministerium fur Bildung und Forschung and the Deutsche
Forschungsgemeinschaft. Dr. Herpertz-Dohlmann has served as a consultant
to Eli Lilly and Co. and has received industry research funding from
Medice and Vifor. Dr. Konrad has served as an editorial board member of
the Journal of Neural Transmission, the Journal of Child Psychology, and
Zeitschrift fur Kinder-und Jugendpsychiatrie, has received speaking fees
from Eli Lilly and Co., Novartis, and Medice, has received industry
research funding from Vifor, and has received research support from the
Bundesministerium fur Bildung und Forschung and the Deutsche
Forschungsgemeinschaft. Drs. Schulte-Ruther and Mainz report no
biomedical financial interests or potential conflicts of interest.
CR Bydlowski S, 2005, INT J EAT DISORDER, V37, P321, DOI 10.1002/eat.20132
Casanova R, 2007, NEUROIMAGE, V34, P137, DOI 10.1016/j.neuroimage.2006.09.011
Castelli F, 2002, BRAIN, V125, P1839, DOI 10.1093/brain/awf189
Connan F, 2003, PHYSIOL BEHAV, V79, P13, DOI 10.1016/S0031-9384(03)00101-X
Davies H, 2012, EUR EAT DISORD REV, V20, P211, DOI 10.1002/erv.2170
Decety J, 2007, NEUROSCIENTIST, V13, P580, DOI 10.1177/1073858407304654
Dietrich T, 2001, NEUROIMAGE, V13, P425, DOI 10.1006/nimg.2001.0703
Fairburn CG, 1999, ARCH GEN PSYCHIAT, V56, P468, DOI 10.1001/archpsyc.56.5.468
Frith CD, 2006, NEURON, V50, P531, DOI 10.1016/j.neuron.2006.05.001
Gallagher HL, 2003, TRENDS COGN SCI, V7, P77, DOI 10.1016/S1364-6613(02)00025-6
Gillberg C, 1996, EUR CHILD ADOLES PSY, V5, P52
Gillberg IC, 2010, J CLIN EXP NEUROPSYC, V32, P358, DOI 10.1080/13803390903066857
GILLBERG IC, 1994, J AM ACAD CHILD PSY, V33, P729, DOI 10.1097/00004583-199406000-00014
Herpertz-Dahlmann B, 2009, CHILD ADOL PSYCH CL, V18, P31, DOI 10.1016/j.chc.2008.07.005
Herpertz-Dahlmann B, 2009, CHILD ADOL PSYCH CL, V18, P131, DOI 10.1016/j.chc.2008.07.010
Herpertz-Dahlmann B, 2011, PEDIAT PSYCHOPHARMAC, P570
Kaye WH, 2004, AM J PSYCHIAT, V161, P2215, DOI 10.1176/appi.ajp.161.12.2215
Kingston K, 1996, PSYCHOL MED, V26, P15
Klin A, 2000, J CHILD PSYCHOL PSYC, V41, P831, DOI 10.1017/S0021963099006101
Krug I, 2012, J HEALTH PSYCHOL, DOI [10.1177/1359105311435946, DOI 10.1177/1359105311435946]
Lock J, 2011, CURR OPIN PSYCHIATR, V24, P274, DOI 10.1097/YCO.0b013e328346f71e
Lopez C, 2008, PSYCHOL MED, V38, P1393, DOI 10.1017/S0033291708003486
Mainz V, 2012, PSYCHOSOM MED, V74, P574, DOI 10.1097/PSY.0b013e31824ef10e
McAdams CJ, 2011, PSYCHIAT RES-NEUROIM, V194, P54, DOI 10.1016/j.pscychresns.2011.06.016
Mitchell JP, 2006, NEURON, V50, P655, DOI 10.1016/j.neuron.2006.03.040
MORGAN HG, 1988, BRIT J PSYCHIAT, V152, P367, DOI 10.1192/bjp.152.3.367
Moriguchi Y, 2006, NEUROIMAGE, V32, P1472, DOI 10.1016/j.neuroimage.2006.04.186
Muhlau M, 2007, AM J PSYCHIAT, V164, P1850, DOI 10.1176/appi.ajp.2007.06111861
Oldershaw A, 2010, PSYCHOSOM MED, V72, P73, DOI 10.1097/PSY.0b013e3181c6c7ca
Olson IR, 2007, BRAIN, V130, P1718, DOI 10.1093/brain/awm052
Patterson K, 2007, NAT REV NEUROSCI, V8, P976, DOI 10.1038/nrn2277
Plichta MM, 2012, NEUROIMAGE, V60, P1746, DOI 10.1016/j.neuroimage.2012.01.129
Roberts ME, 2007, PSYCHOL MED, V37, P1075, DOI 10.1017/S0033291707009877
Rothschild-Yakar L, 2010, J NERV MENT DIS, V198, P501, DOI 10.1097/NMD.0b013e3181e526c8
Rubia K, 2011, HUM BRAIN MAPP, V32, P601, DOI 10.1002/hbm.21048
Russell TA, 2009, PSYCHIAT RES, V168, P181, DOI 10.1016/j.psychres.2008.10.028
Schulte-Ruther M, 2007, J COGNITIVE NEUROSCI, V19, P1354, DOI 10.1162/jocn.2007.19.8.1354
Schultz RT, 2003, PHILOS T ROY SOC B, V358, P415, DOI 10.1098/rstb.2002.1208
Simmons WK, 2009, J INT NEUROPSYCH SOC, V15, P645, DOI 10.1017/S1355617709990348
Skarderud F, 2007, EUR EAT DISORD REV, V15, P323, DOI 10.1002/erv.817
Sobanski E, 1999, EUR CHILD ADOLES PSY, V8, P312
Strober M, 1997, INT J EAT DISORDER, V22, P339
Troop NA, 2002, BRIT J CLIN PSYCHOL, V41, P205, DOI 10.1348/014466502163976
Wagner A, 2006, BIOL PSYCHIAT, V59, P291, DOI 10.1016/j.biopsych.2005.06.014
Wentz E, 2009, BRIT J PSYCHIAT, V194, P168, DOI 10.1192/bjp.bp.107.048686
Zucker NL, 2007, PSYCHOL BULL, V133, P976, DOI 10.1037/0033-2909.133.6.976
NR 46
TC 16
Z9 17
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0890-8567
J9 J AM ACAD CHILD PSY
JI J. Am. Acad. Child Adolesc. Psychiatr.
PD AUG
PY 2012
VL 51
IS 8
BP 832
EP 841
DI 10.1016/j.jaac.2012.06.007
PG 10
WC Psychology, Developmental; Pediatrics; Psychiatry
SC Psychology; Pediatrics; Psychiatry
GA 983OJ
UT WOS:000307128300011
PM 22840554
ER
EF