FN Thomson Reuters Web of Science™ VR 1.0 PT J AU Heinecke, K Weise, C Rief, W AF Heinecke, Kristin Weise, Cornelia Rief, Winfried TI Biofeedback Therapy in Chronic Tinnitus: Effectiveness of a Psychophysiological Treatment SO APPLIED PSYCHOPHYSIOLOGY AND BIOFEEDBACK LA English DT Meeting Abstract DE Psychophysiology; Tinnitus C1 [Heinecke, Kristin; Weise, Cornelia; Rief, Winfried] Univ Marburg, Sect Clin Psychol & Psychotherapy, D-35032 Marburg, Germany. EM heineckk@staff.uni-marburg.de RI Weise, Cornelia/G-6825-2013 NR 0 TC 0 Z9 0 PU SPRINGER/PLENUM PUBLISHERS PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1090-0586 J9 APPL PSYCHOPHYS BIOF JI Appl. Psychophysiol. Biofeedback PD DEC PY 2008 VL 33 IS 4 BP 245 EP 246 PG 2 WC Psychology, Clinical SC Psychology GA 369GL UT WOS:000260682400028 ER PT J AU Takeda, T Kakigi, A Nishioka, R Taguchi, D Nishimura, M AF Takeda, Taizo Kakigi, Akinobu Nishioka, Rie Taguchi, Daizo Nishimura, Masahiko TI Plasma antidiuretic hormone in cases with the early onset of profound unilateral deafness SO AURIS NASUS LARYNX LA English DT Article DE Juvenile unilateral profound deafness; Antidiuretic hormone; Endolymphatic hydrops; Delayed endolymphatic hydrops ID DELAYED ENDOLYMPHATIC HYDROPS; VASOPRESSIN LEVELS; MENIERES-DISEASE; CHILDREN; OSMOREGULATION; SECRETION; ADH AB Objective: The p-ADH level in cases of juvenile unilateral profound deafness (JUPD) and the timecourse of the level were examined to investigte whether or not an increase of p-ADH is involved in the development of delayed endolymphatic hydrops (DEH) in JUPD. Materials and methods: In 90 consecutive patients with unilateral profound or total sensorineural deafness with the onset in early childhood, pure-tone audiometric examination and the measurement of p-ADH and plasma osmolality (p-OSM) were followed up once or twice a year as far as possible. At every testing. we performed careful history-taking about episodic vertigo/dizziness, fluctuant hearing loss, and tinnitus in order to find out whether patients had experienced these clinical signs of the development of DEH. Results: Means and standard deviation (S.D.) of p-ADH level and osmolality in all samples tested (n = 368) were 7.3 +/- 7.0 pg/mL (0.7-52.0 pg/mL). and 288.6 +/- 4.4 mOsm/L (273-306 mOsm/L). respectively. The mean of p-ADH level was much higher than those previously reported in children and adolescents. High levels of p-ADH (over 5.0 pg/mL) were often observed in subjects between 6 and 19 years of age. bill not so frequently in subjects of 20 years of we or older. Long-term follow-up of p-ADH levels revealed that DEH frequently developed in cases with persistent elevation of p-ADH. Conclusions: The elevation of p-ADH is likely to promote the development of DEH in cases of JUPD, although the underlying mechanism remains to he elucidated. (C) 2008 Elsevier Ireland Ltd. All rights reserved. C1 [Takeda, Taizo; Kakigi, Akinobu; Nishioka, Rie; Taguchi, Daizo; Nishimura, Masahiko] Kochi Med Sch, Dept Otolaryngol, Nanko Ku, Kochi 7838505, Japan. RP Takeda, T (reprint author), Kochi Med Sch, Dept Otolaryngol, Nanko Ku, Oko Cho, Kochi 7838505, Japan. EM takedat@kochi-u.ac.jp CR ANDERSSON B, 1973, Conditional Reflex, V8, P147 Aoki M, 2005, CLIN OTOLARYNGOL, V30, P521, DOI 10.1111/j.1749-4486.2005.01107.x AZZENA GB, 1993, ARCH ITAL BIOL, V131, P127 BARTOLI E, 1989, AM J PHYSIOL, V257, pF341 BAYLIS PH, 1988, CLIN ENDOCRINOL, V29, P549, DOI 10.1111/j.1365-2265.1988.tb03704.x de Torrente A, 1975, Kidney Int, V8, P355, DOI 10.1038/ki.1975.127 Engelmann M, 2004, FRONT NEUROENDOCRIN, V25, P132, DOI 10.1016/j.yfrne.2004.09.001 FEIGIN RD, 1977, AM J CLIN NUTR, V30, P1482 Horii A, 2001, BRAIN RES, V914, P179, DOI 10.1016/S0006-8993(01)02799-8 KAKIGI A, 2006, INT J PEDIATR OTORHI, V1, P192, DOI 10.1016/j.pedex.2006.04.008 Kamei Tamio, 2004, Int Tinnitus J, V10, P137 KAMEI T, 1971, OTOLARYNGOL TOKYO, V43, P349 Kluge M, 1999, CLIN CHEM, V45, P98 NADOL JB, 1975, ANN OTO RHINOL LARYN, V84, P841 Rittig S, 1989, AM J PHYSIOL, V256, P664 ROBERTSON GL, 1976, KIDNEY INT, V10, P25, DOI 10.1038/ki.1976.76 SCHUKNECHT HF, 1995, HEARING LOSS DIZZINE, P1 SCHUKNECHT HF, 1978, ANN OTO RHINOL LARYN, V87, P743 SCHUKNECHT HF, 1990, ANN OTO RHINOL LARYN, V99, P843 TAKEDA T, 2005, MENIERES DIS INNER E, P45 Takeda T, 2000, HEARING RES, V140, P1, DOI 10.1016/S0378-5955(99)00180-X TAKEDA T, 1995, ACTA OTO-LARYNGOL, P219 WATERS CB, 1982, PEDIATR RES, V16, P569, DOI 10.1203/00006450-198207000-00016 WILLE S, 1994, SCAND J UROL NEPHROL, V28, P119 WORFSON RJ, 1975, LARYNGOSCOPE, V85, P1762 NR 25 TC 3 Z9 3 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0385-8146 J9 AURIS NASUS LARYNX JI Auris Nasus Larynx PD DEC PY 2008 VL 35 IS 4 BP 493 EP 499 DI 10.1016/j.anl.2007.12.005 PG 7 WC Otorhinolaryngology SC Otorhinolaryngology GA 372MC UT WOS:000260904700006 PM 18329206 ER PT J AU Woo, HJ Song, SY Kim, YD Bai, CH AF Woo, Hyun-Jae Song, Si-Youn Kim, Yong-Dae Bai, Chang Hoon TI Arteriovenous malformation of the external ear: A case report SO AURIS NASUS LARYNX LA English DT Article DE Arteriovenous malformation ID MANAGEMENT AB Arteriovenous malformation (AVM) is a direct communication between an artery and vein without capillary connections and it is mainly found in the intracranial region. However, in an extracranial region, an AVM of the external ear is relatively uncommon. Recently, we experienced a case of an AVM in the external ear. A 20-year-old male patient presented with pulsatile tinnitus over the past 7 months and a reddish and pulsatile mass of the left external ear. We successfully treated the patient for the AVM in the external ear by complete excision after preoperative selective embolization. (C) 2007 Elsevier Ireland Ltd. All rights reserved. C1 [Woo, Hyun-Jae; Song, Si-Youn; Kim, Yong-Dae; Bai, Chang Hoon] Yeungnam Univ, Dept Otorhinolaryngol Head & Neck Surg, Coll Med, Taegu 705717, South Korea. RP Bai, CH (reprint author), Yeungnam Univ, Dept Otorhinolaryngol Head & Neck Surg, Coll Med, 317-1,Daemyang 5 Dong, Taegu 705717, South Korea. EM baich@med.yu.ac.kr CR ASHINOFF R, 1991, ARCH DERMATOL, V127, P1642, DOI 10.1001/archderm.127.11.1642 JACKSON IT, 1993, PLAST RECONSTR SURG, V91, P1216, DOI 10.1097/00006534-199306000-00006 Kohout MP, 1998, PLAST RECONSTR SURG, V102, P643, DOI 10.1097/00006534-199809030-00006 Lam Samuel M, 2003, Arch Facial Plast Surg, V5, P334, DOI 10.1001/archfaci.5.4.334 Pham TH, 2001, LARYNGOSCOPE, V111, P1390, DOI 10.1097/00005537-200108000-00014 Wu JK, 2005, PLAST RECONSTR SURG, V115, P985, DOI 10.1097/01.PRS.0000154207.87313.DE YAMAMOTO Y, 1994, PLAST RECONSTR SURG, V94, P476, DOI 10.1097/00006534-199409000-00009 NR 7 TC 6 Z9 6 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0385-8146 J9 AURIS NASUS LARYNX JI Auris Nasus Larynx PD DEC PY 2008 VL 35 IS 4 BP 556 EP 558 DI 10.1016/j.anl.2007.11.005 PG 3 WC Otorhinolaryngology SC Otorhinolaryngology GA 372MC UT WOS:000260904700016 PM 18207342 ER PT J AU Kaldo, V Levin, S Widarsson, J Buhrman, M Larsen, HC Andersson, G AF Kaldo, Viktor Levin, Susanna Widarsson, Jenny Buhrman, Monica Larsen, Hans-Christian Andersson, Gerhard TI Internet Versus Group Cognitive-Behavioral Treatment of Distress Associated With Tinnitus: A Randomized Controlled Trial SO BEHAVIOR THERAPY LA English DT Article ID HOSPITAL ANXIETY; DEPRESSION SCALE; SELF-HELP; THERAPY; MANAGEMENT AB Tinnitus distress can be reduced by means of cognitive-behavior therapy (CBT), and the treatment can be delivered in different ways. The most recent format is Internet-based self-help. The aim of this study was to compare this treatment (n= 26) with standard group-based CBT (n=25) in a randomized controlled trial. Outcomes on self-report inventories measuring tinnitus distress were evaluated immediately after and 1 year after treatment. Results showed that both groups had improved, and there were few differences between them. The effect size for the Internet treatment was d=0.73 (95% CI=0.16-1.30) and for the group treatment was d=0.64 (95% CI=0.07-1.21). The Internet treatment consumed less therapist time and was 1.7 times as cost-effective as the group treatment. At pretreatment patients rated the Internet treatment as less credible than the group treatment. In conclusion, Internet treatment for tinnitus distress merits further investigation, as the outcomes achieved are promising. C1 [Kaldo, Viktor] Uppsala Univ, Dept Psychol, SE-75142 Uppsala, Sweden. [Larsen, Hans-Christian] Univ Uppsala Hosp, Uppsala, Sweden. [Andersson, Gerhard] Linkoping Univ, Linkoping Univ Hosp, S-58183 Linkoping, Sweden. RP Kaldo, V (reprint author), Uppsala Univ, Dept Psychol, Box 12 25, SE-75142 Uppsala, Sweden. EM viktor.kaldo@psyk.uu.se RI Kaldo, Viktor/J-2915-2012; Andersson, Gerhard/J-8529-2012 OI Andersson, Gerhard/0000-0003-4753-6745 CR Andersson Gerhard, 2001, Seminars in Hearing, V22, P65, DOI 10.1055/s-2001-13021 Andersson G, 1999, BRIT J AUDIOL, V33, P201 ANDERSSON G, 2002, P 7 INT TINN SEM FRE, P197 Andersson G, 2002, CLIN PSYCHOL REV, V22, P977, DOI 10.1016/S0272-7358(01)00124-6 Andersson G, 2002, PSYCHOSOM MED, V64, P810, DOI 10.1097/01.PSY.0000031577.42041.F8 Andersson G, 2005, INT J AUDIOL, V44, P671, DOI 10.1080/14992020500266720 Andersson G, 2003, J PSYCHOSOM RES, V55, P259, DOI 10.1016/S0022-3999(02)00575-5 Andersson G., 2006, TINNITUS TREATMENT C, P96 Andersson G., 2005, TINNITUS MULTIDISCIP Andersson G., 2006, TINNITUS TREATMENT C, P29 Bastien CH, 2001, SLEEP MED, V2, P297, DOI 10.1016/S1389-9457(00)00065-4 Berry JA, 2002, ARCH OTOLARYNGOL, V128, P1153 BORKOVEC TD, 1972, J BEHAV THER EXP PSY, V3, P257, DOI 10.1016/0005-7916(72)90045-6 Carlbring P, 2005, BEHAV RES THER, V43, P1321, DOI 10.1016/j.brat.2004.10.002 COLES RRA, 1992, CLIN OTOLARYNGOL, V17, P313, DOI 10.1111/j.1365-2273.1992.tb01003.x DAVIES S, 1995, PSYCHOL HEALTH, V10, P129, DOI 10.1080/08870449508401943 Dobie RA, 1999, LARYNGOSCOPE, V109, P1202, DOI 10.1097/00005537-199908000-00004 Everitt BS, 2003, MODERN MED STAT HARGREAVES WA, 1999, COST EFFECTIVENESS P, P85 Henry J. 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Therapy PD DEC PY 2008 VL 39 IS 4 BP 348 EP 359 DI 10.1016/j.beth.2007.10.003 PG 12 WC Psychology, Clinical SC Psychology GA 386TV UT WOS:000261906400004 PM 19027431 ER PT J AU Westin, V Hayes, SC Andersson, G AF Westin, Vendela Hayes, Steven C. Andersson, Gerhard TI Is it the sound or your relationship to it? The role of acceptance in predicting tinnitus impact SO BEHAVIOUR RESEARCH AND THERAPY LA English DT Article DE Tinnitus; Acceptance; Mediation analysis; Tinnitus distress; Defusion; Longitudinal ID COGNITIVE-BEHAVIORAL THERAPY; CHRONIC PAIN; COMMITMENT THERAPY; DEPRESSION SCALE; HOSPITAL ANXIETY; EXPERIENTIAL AVOIDANCE; HANDICAP INVENTORY; COMPONENT ANALYSIS; DISORDERS; VALIDATION AB Tinnitus is an experience of sound in the absence of an appropriate external source. A symptom that can accompany most central or peripheral dysfunctions of the auditory system, tinnitus can lead to significant distress, depression, anxiety, and decreases in life quality. This paper investigated the construct of psychological acceptance in a population of tinnitus patients. First, a cross-sectional Study (N = 77) was conducted in which a tinnitus specific acceptance questionnaire was developed. Results showed that a Tinnitus Acceptance Questionnaire (TAQ) generated good internal consistency. A factor Solution was derived with two factors: activity engagement and tinnitus supression, Second, a longitudinal study (N = 47) investigated the mediating role of acceptance on the relationship between tinnitus distress at baseline and tinnitus distress, anxiety, life quality, and depression at a 7-month follow-up The results. showed full mediation of activity engagement for depression and life quality at follow-up, partial mediation for tinnitus distress, and no mediation for anxiety. The role of acceptance in the negative impact of tinnitus distress merits further investigation. (C) 2008 Elsevier Ltd. All rights reserved. C1 [Westin, Vendela; Andersson, Gerhard] Linkoping Univ, Swedish Inst Disabil Res, Dept Behav Sci & Learning, SE-58183 Linkoping, Sweden. [Hayes, Steven C.] Univ Nevada, Dept Psychol, Reno, NV 89557 USA. [Andersson, Gerhard] Karolinska Inst, Psychiat Sect, Dept Clin Neurosci, Stockholm, Sweden. RP Andersson, G (reprint author), Linkoping Univ, Swedish Inst Disabil Res, Dept Behav Sci & Learning, Campus Valla, SE-58183 Linkoping, Sweden. 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Res. Ther. PD DEC PY 2008 VL 46 IS 12 BP 1259 EP 1265 DI 10.1016/j.brat.2008.08.008 PG 7 WC Psychology, Clinical SC Psychology GA 384OQ UT WOS:000261754500002 PM 18926522 ER PT J AU Bosnyak, D Gander, P Roberts, L AF Bosnyak, Daniel Gander, Phillip Roberts, Larry TI Does the amplitude of the 40-Hz auditory steady-state response track the tinnitus percept? SO CANADIAN JOURNAL OF EXPERIMENTAL PSYCHOLOGY-REVUE CANADIENNE DE PSYCHOLOGIE EXPERIMENTALE LA English DT Meeting Abstract C1 [Bosnyak, Daniel; Gander, Phillip; Roberts, Larry] McMaster Univ, Hamilton, ON L8S 4L8, Canada. NR 0 TC 0 Z9 0 PU CANADIAN PSYCHOLOGICAL ASSOC PI OTTAWA PA 141 LAURIER AVE WEST, STE 702, OTTAWA, ONTARIO K1P 5J3, CANADA SN 1196-1961 J9 CAN J EXP PSYCHOL JI Can. J. Exp. Psychol.-Rev. Can. Psychol. Exp. PD DEC PY 2008 VL 62 IS 4 BP 263 EP 263 PG 1 WC Psychology, Experimental SC Psychology GA 531LK UT WOS:000272667400023 ER PT J AU Eggermont, JJ AF Eggermont, Jos J. TI The Role of Sound in Adult and Developmental Auditory Cortical Plasticity SO EAR AND HEARING LA English DT Review ID INDUCED HEARING-LOSS; ENRICHED ACOUSTIC ENVIRONMENT; CORRELATED NEURAL ACTIVITY; LOCAL-FIELD POTENTIALS; COCHLEAR IMPLANT USE; NOISE-TRAUMA; EVOKED-POTENTIALS; CORTEX; CAT; MATURATION AB The purpose of the current review is to highlight the role of the acoustic environment in auditory cortical plasticity. In order do this we have reviewed our past studies on auditory cortical plasticity based on long-latency evoked potential recordings in humans following cochlear implantation, and multiple single-unit recordings from cat auditory cortex following noise trauma and exposure to a non-deafening acoustic environment. The results of these studies, and those of other investigators highlighted here, show that the auditory cortex shows plastic changes throughout life. Those that occur during maturation are typically considered the most profound and long lasting. In that case plasticity is beneficial as it allows adaptation to behaviorally important sound and adapts easily to changes induced by deafness and subsequent application of hearing aids or cochlear implants. In children as well as adults, changes in cortical representation of frequency can occur following hearing loss, but may be accompanied by unpleasant side effects such as tinnitus. Long exposure to a spectrally enhanced acoustic environment of moderate sound level that does not cause hearing loss paradoxically also results in pronounced changes in the cortical tonotopic maps. These changes are very similar to those following noise trauma. This review provides evidence that in adults, long-lasting plastic changes in auditory cortex occur even in the absence of behaviorally relevant acoustic stimulation. However, in children, the long lasting absence of auditory stimulation arrests cortical development. C1 [Eggermont, Jos J.] Univ Calgary, Dept Psychol, Calgary, AB T2N 1N4, Canada. [Eggermont, Jos J.] Univ Calgary, Dept Physiol & Biophys, Calgary, AB T2N 1N4, Canada. RP Eggermont, JJ (reprint author), Univ Calgary, Dept Psychol, 2500 Univ Dr NW, Calgary, AB T2N 1N4, Canada. EM eggermon@ucalgary.ca FU Alberta Heritage Foundation for Medical Research; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Campbell McLaurin Chair for Hearing Deficiencies FX Greg Shaw provided programming assistance. Arnaud Norena, Boris Gourevitch, Pamela Valentine, Naotaka Aizawa, and Martin Pienkowski contributed to the animal data collection. The human data were collected at the House Ear Institute by Curtis Ponton and Manny Don.This work was supported by the Alberta Heritage Foundation for Medical Research, by the Natural Sciences and Engineering Research Council of Canada, by the Canadian Institutes of Health Research, and by the Campbell McLaurin Chair for Hearing Deficiencies.Based on the Carhart Memorial Lecture 2008. 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PD DEC PY 2008 VL 29 IS 6 BP 819 EP 829 DI 10.1097/AUD.0b013e3181853030 PG 11 WC Audiology & Speech-Language Pathology; Otorhinolaryngology SC Audiology & Speech-Language Pathology; Otorhinolaryngology GA 371DY UT WOS:000260813200001 PM 18941413 ER PT J AU Bartels, H Middel, BL van der Laan, BFAM Staal, MJ Albers, FWJ AF Bartels, H. Middel, B. L. van der Laan, B. F. A. M. Staal, M. J. Albers, F. W. J. TI The Additive Effect of Co-Occurring Anxiety and Depression on Health Status, Quality of Life and Coping Strategies in Help-Seeking Tinnitus Sufferers SO EAR AND HEARING LA English DT Article ID PERCUTANEOUS CORONARY INTERVENTION; PSYCHOLOGICAL DISTRESS; HOSPITAL ANXIETY; PSYCHIATRIC-DISORDERS; PSYCHOMETRIC PROPERTIES; REACTION QUESTIONNAIRE; EMOTIONAL DISTRESS; HANDICAP INVENTORY; SURVEY SF-36; SEVERITY AB Objective: Evaluating the effect of anxiety and depression on clinical measures of general health, tinnitus-specific quality of life, and coping abilities. Design: Two hundred sixty-five chronic, subjective tinnitus sufferers were divided into four psychological symptom groups according to cut-off scores on anxiety and depression subscales of the Hospital Anxiety and Depression Scale: (1) no-symptoms, (2) anxiety-only, (3) depression-only, and (4) anxiety-plus-depression. General health-related quality of life (SF-36), tinnitus-specific quality of life (tinnitus reaction questionnaire and tinnitus handicap inventory), and coping abilities (tinnitus coping style questionnaire) were assessed and analyzed across these four psychological symptom groups, which did not differ on age, gender, marital, and working status. Results: Statistically significant and clinically relevant differences on general health-related and tinnitus-specific quality of life and coping abilities were identified when comparing anxiety-plus-depression subgroup with the subgroups anxiety-only, depression-only, or no-symptoms. Highest associations were seen between the anxiety-plus-depression subgroup and impaired quality of life and maladaptive coping. Conclusions: Our results demonstrate the additive effect of both anxiety and depression in impairing general health-related and tinnitus-specific quality of life and application of coping strategies, and reiterate the need for investigating both symptoms in the clinical evaluation of tinnitus patients. C1 [Bartels, H.; van der Laan, B. F. A. M.] Univ Groningen, Univ Med Ctr Groningen, Dept Otorhinolaryngol, NL-9700 RB Groningen, Netherlands. [Middel, B. L.] Univ Groningen, Univ Med Ctr Groningen, Dept Hlth Sci, NL-9700 RB Groningen, Netherlands. [Middel, B. L.] Univ Groningen, Univ Med Ctr Groningen, Dept Oral Hlth & Clin Epidemiol, NL-9700 RB Groningen, Netherlands. [Staal, M. J.] Univ Groningen, Univ Med Ctr Groningen, Dept Neurosurg, NL-9700 RB Groningen, Netherlands. [Albers, F. W. 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PD DEC PY 2008 VL 29 IS 6 BP 947 EP 956 DI 10.1097/AUD.0b013e3181888f83 PG 10 WC Audiology & Speech-Language Pathology; Otorhinolaryngology SC Audiology & Speech-Language Pathology; Otorhinolaryngology GA 371DY UT WOS:000260813200012 PM 18941410 ER PT J AU Wenzel, GI Gotz, F Lenarz, T Stover, T AF Wenzel, Gentiana I. Goetz, Friedrich Lenarz, Thomas Stoever, Timo TI HIV-associated cerebral lymphocyte infiltration mimicking vestibular schwannoma SO EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY LA English DT Article DE Acoustic neuroma; Vestibular schwannoma; HIV; Cerebral lymphocyte infiltration; Lymphoma ID CENTRAL-NERVOUS-SYSTEM; PRIMARY CNS LYMPHOMA; NON-HODGKIN-LYMPHOMA; CEREBELLOPONTINE ANGLE; TUMORS; LESIONS; AIDS; DISORDERS; FOSSA AB The association of unilateral, rapidly progressive hearing loss, tinnitus and vestibular dysfunction in combination with a contrast-enhancing mass within the internal auditory canal on MRI is suggestive of a vestibular schwannoma (VS). We report the rare finding of a HIV-associated cerebral lymphocyte infiltration, most probably malignant lymphoma, which was presumed initially to be a VS. A 36-year-old male presented with progressive unilateral hearing loss accompanied by acute, ipsilateral tinnitus. Interpreted first as sudden sensorineural hearing loss, his symptoms were treated with rheologic therapy. Ipsilateral facial palsy appeared. MRI with gadolininium disclosed a contrast-enhancing mass within the internal auditory meatus of the left side. Within five weeks an extended leptomeningeal lymphocyte infiltration evolved and the diagnosis of an underlying HIV infection was made. Unilateral, rapidly progressive hearing loss and a fast growing cerebello-pontine mass is atypical for VS and highly suspicious of malignant disease. To our knowledge we report the first case of an HIV-associated cerebral lymphocyte infiltration, mimicking a VS. In such cases the diagnostic work-up should include a HIV test. 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Arch. Oto-Rhino-Laryn. PD DEC PY 2008 VL 265 IS 12 BP 1567 EP 1571 DI 10.1007/s00405-008-0617-9 PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA 364AE UT WOS:000260307800022 PM 18317791 ER PT J AU Roberts, LE Moffat, G Baumann, M Ward, LM Bosnyak, DJ AF Roberts, Larry E. Moffat, Graeme Baumann, Michael Ward, Lawrence M. Bosnyak, Daniel J. TI Residual Inhibition Functions Overlap Tinnitus Spectra and the Region of Auditory Threshold Shift SO JARO-JOURNAL OF THE ASSOCIATION FOR RESEARCH IN OTOLARYNGOLOGY LA English DT Article DE residual inhibition; tinnitus spectra; neural synchrony; cortical reorganization ID HEARING-LOSS; PURE-TONES; DEAD REGIONS; LATERALIZED TINNITUS; NEURAL ACTIVITY; FREQUENCY; CORTEX; ACTIVATION; MASKING; PERCEPTION AB Animals exposed to noise trauma show augmented synchronous neural activity in tonotopically reorganized primary auditory cortex consequent on hearing loss. Diminished intracortical inhibition in the reorganized region appears to enable synchronous network activity that develops when deafferented neurons begin to respond to input via their lateral connections. In humans with tinnitus accompanied by hearing loss, this process may generate a phantom sound that is perceived in accordance with the location of the affected neurons in the cortical place map. The neural synchrony hypothesis predicts that tinnitus spectra, and heretofore unmeasured "residual inhibition functions" that relate residual tinnitus suppression to the center frequency of masking sounds, should cover the region of hearing loss in the audiogram. We confirmed these predictions in two independent cohorts totaling 90 tinnitus subjects, using computer-based tools designed to assess the psychoacoustic properties of tinnitus. Tinnitus spectra and residual inhibition functions for depth and duration increased with the amount of threshold shift over the region of hearing impairment. Residual inhibition depth was shallower when the masking sounds that were used to induce residual inhibition showed decreased correspondence with the frequency spectrum and bandwidth of the tinnitus. These findings suggest that tinnitus and its suppression in residual inhibition depend on processes that span the region of hearing impairment and not on mechanisms that enhance cortical representations for sound frequencies at the audiometric edge. Hearing thresholds measured in age-matched control subjects without tinnitus implicated hearing loss as a factor in tinnitus, although elevated thresholds alone were not sufficient to cause tinnitus. C1 [Roberts, Larry E.; Moffat, Graeme; Bosnyak, Daniel J.] McMaster Univ, Dept Psychol Neurosci & Behav, Hamilton, ON L8S 4K1, Canada. [Baumann, Michael; Ward, Lawrence M.] Univ British Columbia, Dept Psychol, Vancouver, BC V6T 1Z4, Canada. [Ward, Lawrence M.] Univ British Columbia, Brain Res Ctr, Vancouver, BC V6T 1Z4, Canada. RP Roberts, LE (reprint author), McMaster Univ, Dept Psychol Neurosci & Behav, 1280 Main St W, Hamilton, ON L8S 4K1, Canada. EM roberts@mcmaster.ca; bosnyak@mcmaster.ca FU Canadian Institutes of Health Research (CIHR NET Programme); NSERC of Canada; American Tinnitus Association FX This research was funded by the Canadian Institutes of Health Research (CIHR NET Programme), NSERC of Canada, and the American Tinnitus Association. Dave Thompson, Oksana Smyczyk, Phillip Gander, and Stephanie Thai assisted in conducting the study. We thank two anonymous reviewers and Richard Tyler for their insightful comments on an earlier version of the manuscript. 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Klein, Britt Austin, David W. Gilson, Kathryn Pier, Ciaran Mitchell, Joanna Ciechomski, Lisa TI Is internet-based CBT for panic disorder and agoraphobia as effective as face-to-face CBT? SO JOURNAL OF ANXIETY DISORDERS LA English DT Article DE Internet-based therapy; Cognitive behavioral therapy; Panic disorder; Agoraphobia ID RANDOMIZED CONTROLLED-TRIAL; COGNITIVE-BEHAVIORAL THERAPY; SELF-HELP; APPLIED RELAXATION; FOLLOW-UP; QUESTIONNAIRE; PROGRAM; DEPRESSION; TINNITUS AB This study compared Panic Online (PO), an internet-based CBT intervention, to best-practice face-to-face CBT for people with panic disorder with or without agoraphobia. Eighty-six people with a primary diagnosis of panic disorder were recruited from Victoria, Australia. Participants were randomly assigned to either PO (n = 46) or best practice face-to-face CBT (11 = 40). Effects of the internet-based CBT prograrn were found to be comparable to those of face-to-face CBT. Both interventions produced significant reductions in panic disorder and agoraphobia clinician severity ratings, self reported panic disorder sevefity and panic attack frequency, measures of depression, anxiety, stress and panic related cognitions, and displayed improvements in quality of life. Participants rated both treatment conditions as equally credible and satisfying. Participants in the face-to-face CBT treatment group cited higher enjoyment with communicating with their therapist. Consistent with this, therapists' ratings for compliance to treatment and understanding of the CBT material was higher in the face-to-face CBT treatment group. PO required significantly less therapist time than the face-to-face CBT condition. (c) 2008 Elsevier Ltd. All rights reserved. C1 [Kiropoulos, Litza A.; Klein, Britt; Austin, David W.; Gilson, Kathryn; Pier, Ciaran; Mitchell, Joanna; Ciechomski, Lisa] Monash Univ, Sch Primary Hlth Care, Dept Gen Practice, Notting Hill, Vic 3168, Australia. RP Kiropoulos, LA (reprint author), Monash Univ, Sch Primary Hlth Care, Dept Gen Practice, Bldg 1,270 Ferntree Gully Rd, Notting Hill, Vic 3168, Australia. 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Anxiety Disord. PD DEC PY 2008 VL 22 IS 8 BP 1273 EP 1284 DI 10.1016/j.janxdis.2008.01.008 PG 12 WC Psychology, Clinical; Psychiatry SC Psychology; Psychiatry GA 361TV UT WOS:000260150900001 PM 18289829 ER PT J AU Weise, C Heinecke, K Rief, W AF Weise, Cornelia Heinecke, Kristin Rief, Winfried TI Biofeedback-Based Behavioral Treatment for Chronic Tinnitus: Results of a Randomized Controlled Trial SO JOURNAL OF CONSULTING AND CLINICAL PSYCHOLOGY LA English DT Article DE tinnitus; CBT; psychophysiological treatment; randomized controlled trial ID EMOTIONAL DISTRESS; TEMPOROMANDIBULAR DISORDERS; PSYCHOLOGICAL TREATMENT; PSYCHIATRIC-DISORDERS; COGNITIVE THERAPY; COPING STYLE; MANAGEMENT; SUFFERERS; SEVERITY; ASSOCIATION AB Many tinnitus sufferers believe that their tinnitus has an organic basis and thus seek medical rather than psychological treatments. Tinnitus has been found to be associated with negative appraisal. dysfunctional attention shift, and heightened psychophysiological arousal, so cognitive-behavioral interventions and biofeedback are commonly suggested as treatments. This study developed and investigated the efficacy of a biofeedback-based cognitive-behavioral treatment for tinnitus. In total, 130 tinnitus patients were randomly assigned to an intervention or a wait-list control group. Treatment consisted of 12 sessions of a biofeedback-based behavioral intervention over a 3-month period. Patients in the wait-list group participated in the treatment after the intervention group had completed the treatment. Results showed clear improvements regarding tinnitus annoyance, diary ratings of loudness, and feelings of controllability. Furthermore. changes in coping cognitions as well as changes in depressive symptoms were found. Improvements were maintained over a 6-month follow-up period in which medium-to-large effect sizes were observed. The treatment developed and investigated in this study is well accepted and leads to clear and stable improvements. Through demonstration of psychophysiological interrelationships, the treatment enables patients to change their somatic illness perceptions to a more psychosomatic point of view. C1 [Weise, Cornelia; Heinecke, Kristin; Rief, Winfried] Univ Marburg, Fac Psychol, Sect Clin Psychol & Psychotherapy, D-35032 Marburg, Germany. RP Weise, C (reprint author), Univ Marburg, Fac Psychol, Sect Clin Psychol & Psychotherapy, Gutenbergstr 18, D-35032 Marburg, Germany. 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Consult. Clin. Psychol. PD DEC PY 2008 VL 76 IS 6 BP 1046 EP 1057 DI 10.1037/a0013811 PG 12 WC Psychology, Clinical SC Psychology GA 375KP UT WOS:000261113000013 PM 19045972 ER PT J AU Marhold, F Preusser, M Dietrich, W Prayer, D Czech, T AF Marhold, Franz Preusser, Matthias Dietrich, Wolfgang Prayer, Daniela Czech, Thomas TI Clinicoradiological features of rosette-forming glioneuronal tumor (RGNT) of the fourth ventricle: report of four cases and literature review SO JOURNAL OF NEURO-ONCOLOGY LA English DT Review DE Rosette-forming glioneuronal tumor; RGNT; Posterior fossa tumor; Cerebral tumor hemorrhage ID DYSEMBRYOPLASTIC NEUROEPITHELIAL TUMOR AB Background Rosette-forming glioneuronal tumor (RGNT) of the fourth ventricle is a recently characterized rare tumor entity. Despite benign histological features and a reported favorable postoperative course, there is still limited clinical experience with this tumor. Methods Retrospective analysis of the clinical, radiological, and surgical data in four patients with RGNT was performed. Mean age at diagnosis was 35 years, and the median follow-up was 19 (range 2-30) months. The results were compared with the literature. Results Patient 1 presented on an emergency basis due to intratumoral hemorrhage and tumor enlargement followed by life-threatening obstructive hydrocephalus. Patient 2 suffered from headaches and left-sided hemiparesthesia 6 months prior to surgery. Patient 3 developed headaches with nausea and vomiting, followed by left-sided tinnitus 1 year prior to surgery. In patient 4, RGNT was detected incidentally. No differentiating radiological characteristics were seen except for the presence of minute satellite lesions in two patients. Histopathological findings were distinct and showed their typical biphasic neurocytic and glial architecture. No progression/recurrence was seen in the postoperative course. Conclusions The spectrum of presenting symptoms of RGNT is wide, nonspecific, and typically depends on tumor size and extent. This tumor entity should be considered in the differential diagnosis of posterior fossa masses in order to avoid undue surgical aggressiveness. C1 [Marhold, Franz; Dietrich, Wolfgang; Czech, Thomas] Med Univ Vienna, Dept Neurosurg, A-1090 Vienna, Austria. [Preusser, Matthias] Med Univ Vienna, Inst Neurol, A-1090 Vienna, Austria. [Prayer, Daniela] Med Univ Vienna, Dept Radiol, Div Neuroradiol, A-1090 Vienna, Austria. RP Czech, T (reprint author), Med Univ Vienna, Dept Neurosurg, Wahringer Gurtel 18-20, A-1090 Vienna, Austria. 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Neuro-Oncol. PD DEC PY 2008 VL 90 IS 3 BP 301 EP 308 DI 10.1007/s11060-008-9661-y PG 8 WC Oncology; Clinical Neurology SC Oncology; Neurosciences & Neurology GA 370NG UT WOS:000260768300009 PM 18777116 ER PT J AU Kitahara, T Doi, K Maekawa, C Kizawa, K Horii, A Kubo, T Kiyama, H AF Kitahara, T. Doi, K. Maekawa, C. Kizawa, K. Horii, A. Kubo, T. Kiyama, H. TI Meniere's Attacks Occur in the Inner Ear with Excessive Vasopressin Type-2 Receptors SO JOURNAL OF NEUROENDOCRINOLOGY LA English DT Article DE Meniere's disease; inner ear; stress hormone; vasopressin; V2 receptor; cAMP ID ENDOLYMPHATIC HYDROPS; DISEASE; SAC; HORMONE; STEROIDS AB Meniere's disease is peculiar to humans and is characterised by episodic vertigo, fluctuating hearing loss and tinnitus, and attacks of the affliction occurring under conditions of stress. Its pathology was first revealed to be inner ear hydrops through temporal bone studies in 1938. Although subsequently proposed as a disorder of water metabolism in the inner ear, its pathogenesis remains unsolved. The present study aimed to assess the link between the inner ear pathology in Meniere's disease and vasopressin, an anti-diuretic stress hormone with a potential role in inner ear fluid homeostasis. Blood samples were obtained from Meniere's disease patients in the morning, before any surgical treatment, to examine plasma vasopressin (pAVP) levels, and then from inner ear tissue during surgical treatment, to examine vasopressin type-2 receptor (V2R) in the endolymphatic sac. pAVP and the relative V2R mRNA expression in the endolymphatic sac were examined using a real-time polymerase chain reaction. Relative cAMP activity in the endolymphatic sac was also examined using tissue culture and cAMP assay. Both pAVP (1.6-fold versus controls; P = 0.048) and inner ear V2R mRNA expression (41.5-fold versus controls; P = 0.022) were significantly higher in Meniere's patients. cAMP activity was basally up-regulated (2.1-fold versus controls) and cAMP sensitivity to vasopressin application was largely elevated (4.9-fold versus controls) in Meniere's patients. We conclude that, in the pathogenesis of inner ear hydrops, resulting in Meniere's attacks, elevation of pAVP levels (probably as a result of stress) may present as a matter of consequence, but susceptibility of the V2R-overexpressed and cAMP-hypersensitised inner ear to pAVP elevation might be essential as the basis of this disease. Further experimental and clinical studies are needed to better clarify the relationship between Meniere's disease and stress. C1 [Kitahara, T.; Doi, K.; Maekawa, C.; Kizawa, K.; Horii, A.; Kubo, T.] Osaka Univ, Sch Med, Dept Otolaryngol, Suita, Osaka 5650871, Japan. [Kiyama, H.] Osaka City Univ, Sch Med, Dept Neuroanat, Osaka 545, Japan. RP Kitahara, T (reprint author), Osaka Univ, Sch Med, Dept Otolaryngol, 2-2 Yamada Oka, Suita, Osaka 5650871, Japan. EM tkitahara@ent.med.osaka-u.ac.jp RI Kiyama, Hiroshi/M-8867-2014 FU Ministry of Health, Labour and Welfare, Japan FX This study was supported in part by a Health Science Research Grant for Specific Disease from the Ministry of Health, Labour and Welfare, Japan (2005 - 2007). CR Aoki M, 2007, J NEUROENDOCRINOL, V19, P901, DOI 10.1111/j.1365-2826.2007.01601.x Claes J, 2000, ACTA OTO-LARYNGOL, P34 Committee on Hearing and Equilibirum, 1995, OTOLARYNGOL HEAD NEC, V113, P181 GUTIERREZ F, 1994, LARYNGOSCOPE, V104, P1495 Hallpike C. 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Neuroendocrinol. PD DEC PY 2008 VL 20 IS 12 BP 1295 EP 1300 DI 10.1111/j.1365-2826.2008.01792.x PG 6 WC Endocrinology & Metabolism; Neurosciences SC Endocrinology & Metabolism; Neurosciences & Neurology GA 375LP UT WOS:000261115700001 PM 19094077 ER PT J AU Langguth, B Landgrebe, M Hajak, G Kleinjung, T AF Langguth, Berthold Landgrebe, Michael Hajak, Goeran Kleinjung, Tobias TI In Reference to Maintenance Repetitive Transcranial Magnetic Stimulation can Inhibit the Return of Tinnitus SO LARYNGOSCOPE LA English DT Letter ID TINNITUS; RTMS C1 [Langguth, Berthold; Landgrebe, Michael; Hajak, Goeran; Kleinjung, Tobias] Univ Regensburg, Multidisciplinary Tinnitus Clin, Regensburg, Germany. RP Langguth, B (reprint author), Univ Regensburg, Multidisciplinary Tinnitus Clin, Regensburg, Germany. CR Klein A, 2007, EUR J PEDIATR, V166, P359, DOI 10.1007/s00431-006-0247-4 Kleinjung T, 2008, OTOLARYNG HEAD NECK, V138, P497, DOI 10.1016/j.otohns.2007.12.022 Langguth B, 2003, NEUROREPORT, V14, P977, DOI 10.1097/01.wnr.0000068897.39523.41 Langguth B, 2006, J CLIN PSYCHIAT, V67, P835 Mennemeier M, 2008, LARYNGOSCOPE, V118, P1228, DOI 10.1097/MLG.0b013e318170f8ac O'Reardon JP, 2005, J CLIN PSYCHIAT, V66, P1524 NR 6 TC 6 Z9 6 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0023-852X J9 LARYNGOSCOPE JI Laryngoscope PD DEC PY 2008 VL 118 IS 12 BP 2264 EP 2264 DI 10.1097/MLG.0b013e318182c325 PG 1 WC Medicine, Research & Experimental; Otorhinolaryngology SC Research & Experimental Medicine; Otorhinolaryngology GA 405CV UT WOS:000263200900033 PM 19057280 ER PT J AU Mennemeier, MS Dornhoffer, J AF Mennemeier, Mark Stephen Dornhoffer, John TI In Reference to Maintenance Repetitive Transcranial Magnetic Stimulation can Inhibit the Return of Tinnitus Reply SO LARYNGOSCOPE LA English DT Letter ID CHRONIC TINNITUS C1 [Mennemeier, Mark Stephen] Univ Arkansas Med Sci, Dept Neurobiol & Dev Sci, Little Rock, AR 72205 USA. [Dornhoffer, John] Univ Arkansas Med Sci, Dept Otolaryngol Head & Neck Surg, Little Rock, AR 72205 USA. RP Mennemeier, MS (reprint author), Univ Arkansas Med Sci, Dept Neurobiol & Dev Sci, Little Rock, AR 72205 USA. CR De Ridder Dirk, 2007, Int J Med Sci, V4, P237 Kleinjung T, 2008, OTOLARYNG HEAD NECK, V138, P497, DOI 10.1016/j.otohns.2007.12.022 Langguth B, 2003, NEUROREPORT, V14, P977, DOI 10.1097/01.wnr.0000068897.39523.41 Plewnia C, 2007, J NEUROL NEUROSUR PS, V78, P152, DOI 10.1136/jnnp.2006.095612 Rossi S, 2007, J NEUROL NEUROSUR PS, V78, P857, DOI 10.1136/jnnp.2006.105007 Smith JA, 2007, LARYNGOSCOPE, V117, P529, DOI 10.1097/MLG.0b013e31802f4154 NR 6 TC 1 Z9 1 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0023-852X J9 LARYNGOSCOPE JI Laryngoscope PD DEC PY 2008 VL 118 IS 12 BP 2264 EP 2265 DI 10.1097/MLG.0b013e318182c337 PG 3 WC Medicine, Research & Experimental; Otorhinolaryngology SC Research & Experimental Medicine; Otorhinolaryngology GA 405CV UT WOS:000263200900034 ER PT J AU Saito, A Furuno, Y Nishimura, S Kamiyama, H Nishijima, M AF Saito, Atsushi Furuno, Yuuichi Nishimura, Shinjitsu Kamiyama, Hironaga Nishijima, Michiharu TI Spontaneous Closure of Transverse Sinus Dural Arteriovenous Fistula SO NEUROLOGIA MEDICO-CHIRURGICA LA English DT Article DE dural arteriovenous fistula; transverse sinus dural arteriovenous fistula; spontaneous closure; spontaneous occlusion ID SPONTANEOUS REGRESSION; SIGMOID SINUSES; MALFORMATION AB A 60-year-old man presented with transverse sinus dural arteriovenous fistula (AVF) manifesting as sudden onset of headache and nausea, which underwent spontaneous closure 5 years after the onset. Computed tomography on admission revealed small intraventricular hemorrhage in the right lateral ventricle. No intracranial vascular lesion was detected and magnetic resonance angiography was used at yearly follow up. Two years after the first admission, he suffered diplopia and cerebral angiography revealed transverse sinus dural AVF. Right pulsatile tinnitus occurred 4 years after the first admission. The symptoms suddenly disappeared 5 years after the first admission, and follow-up angiography showed disappearance of the dural AVE The exact mechanism of the spontaneous occlusion of dural AVF remains unknown. This case of spontaneous transverse sinus dural AVF closure occurred without disruption of sinus patency, suggesting that thrombosis of the draining veins into sinuses was not involved. C1 [Saito, Atsushi; Furuno, Yuuichi; Nishimura, Shinjitsu; Kamiyama, Hironaga; Nishijima, Michiharu] Aomori Prefectural Cent Hosp, Dept Neurosurg, Aomori, Japan. RP Saito, A (reprint author), Tohoku Univ, Grad Sch Med, Dept Neurosurg, Aoba Ku, 1-1 Seiryo Cho, Sendai, Miyagi 9808574, Japan. EM satsushi2002@yahoo.co.jp CR Abdulrauf SI, 1999, NEUROSURGERY, V44, P280, DOI 10.1097/00006123-199902000-00021 CHAUDHARY MY, 1982, AM J NEURORADIOL, V3, P13 COGNARD C, 1995, RADIOLOGY, V194, P671 ENDO S, 1979, J NEUROSURG, V51, P715, DOI 10.3171/jns.1979.51.5.0715 GRAEB DA, 1986, J NEUROSURG, V64, P962, DOI 10.3171/jns.1986.64.6.0962 HALBACH VV, 1987, RADIOLOGY, V163, P443 HANSEN JH, 1976, J NEUROSURG, V45, P338, DOI 10.3171/jns.1976.45.3.0338 KATAOKA K, 1984, J NEUROSURG, V60, P1275, DOI 10.3171/jns.1984.60.6.1275 LANDMAN JA, 1985, AM J NEURORADIOL, V6, P448 Luciani A, 2001, AM J NEURORADIOL, V22, P992 Magidson M A, 1976, Surg Neurol, V6, P107 Moriya M, 2007, NEUROL SURG TOKYO, V35, P65 NISHIJIMA M, 1992, J NEUROSURG, V76, P600, DOI 10.3171/jns.1992.76.4.0600 OLUTOLA PS, 1983, NEUROSURGERY, V12, P687 ROHR J, 1985, REV NEUROL, V141, P240 Sugiura Y, 1996, NEUROL SURG TOKYO, V24, P379 NR 16 TC 7 Z9 7 PU JAPAN NEUROSURGICAL SOC PI TOKYO PA C/O AKAMON-MAE IWATA BLDG, 5-27-8 HONGO, BUNKYO-KU, TOKYO, 113-0033, JAPAN SN 0470-8105 J9 NEUROL MED-CHIR JI Neurol. Med.-Chir. PD DEC PY 2008 VL 48 IS 12 BP 564 EP 568 PG 5 WC Clinical Neurology; Surgery SC Neurosciences & Neurology; Surgery GA 382ZM UT WOS:000261643900012 PM 19106495 ER PT J AU Vera-Cruz, P Ferreira, M Zagalo, C dos Santos, JM Aguas, AP AF Vera-Cruz, Paulo Ferreira, Marco Zagalo, Carlos dos Santos, Jose Martins Aguas, Artur P. TI Chronic hyperbaric oxygen therapy and the human nasal mucosa: increased thickness of epithelium basement membrane and moderate neutrophilic infiltration SO RHINOLOGY LA English DT Article DE hyperbaric therapy; oxygen; nasal mucosa; basement membrane; neutrophils ID SENSORINEURAL HEARING-LOSS; MUCOCILIARY TRANSPORT; HYPEROXIA; CELLS; INFLAMMATION; FREQUENCY; APOPTOSIS; RESPONSES; EXPOSURE; DAMAGE AB Objective: We aimed to identify potential morphologic changes induced in the nasal mucosa by hyperbaric oxygen (HBO) treatment. Study Design: Biopsies were obtained from two groups of 9 individuals: the first group had a diagnosis of tinnitus and was submitted to 15 sessions of 100 min-long HBO treatments, and the latter group consisted of healthy volunteers nor submitted to HBO therapy. Methods: Small biopsies of the anterior portion of the lower nasal turbinate were collected with the help of a Hartmann forceps under direct visual inspection. The samples were processed for light microscopy and morphometric analysis. Inflammatory infiltration (neutrophils and lymphocytes) was evaluated by a semiquantitative method. Unpaired t test and Bernoulli distribution were applied to evaluate statistical differences between data from the two groups of samples. Results: Samples of the turbinate mucosa of the HBO-treated group showed a significant increase in the thickness of the epithelial basement membrane and a moderate enhancement in infiltrating neutrophils when compared with the samples from the control group. Conclusions: Chronic HBO treatment causes only minor changes in the architecture of the nasal mucosa that may represent the response of the respiratory tract to the increase in pressure and in oxygen content induced by this type of therapy. C1 [Vera-Cruz, Paulo] Hosp Marinha, Serv Otorrinolaringol, Lisbon, Portugal. [Ferreira, Marco] Inst Portugues Oncol Francisco Gentil, Serv Anat Patol, Lisbon, Portugal. [Zagalo, Carlos; dos Santos, Jose Martins] Inst Super Ciencias Saude Egas Moniz, Monte De Caparica, Portugal. [Aguas, Artur P.] ICBAS, Inst Super Ciencias Biomed Abel Salazar, Oporto, Portugal. [Aguas, Artur P.] UMIB, Oporto, Portugal. RP Vera-Cruz, P (reprint author), Rua Poeta Bocage 18,3 Dto, P-1600581 Lisbon, Portugal. EM p_vera_cruz@netcabo.pt CR Bancroft J, 2002, THEORY PRACTICE HIST, VFifth BARTLETT R, 1997, CLIN MANAGEMENT POIS Bossi R, 2004, LARYNGOSCOPE, V114, P1431, DOI 10.1097/00005537-200408000-00022 Bouachour G, 1996, J TRAUMA, V41, P333, DOI 10.1097/00005373-199608000-00023 Capellier G, 1997, ACTA ANAESTH SCAND, V41, P1011 Cho HY, 1999, TOXICOL SCI, V51, P135, DOI 10.1093/toxsci/51.1.135 COLLAN Y, 1984, STEREOLOGY MORPHOLOG, P5 DEITMER T, 1992, ACTA OTO-LARYNGOL, V112, P102, DOI 10.3109/00016489209100790 De Paepe ME, 2005, AM J PHYSIOL-LUNG C, V289, pL647, DOI 10.1152/ajplung.00445.2004 Desloovere C, 2006, B-ENT, V2, P69 DiSabato F, 1996, HEADACHE, V36, P221 Dixon MF, 1996, AM J SURG PATHOL, V20, P1161, DOI 10.1097/00000478-199610000-00001 Dundar K, 2007, J OTOLARYNGOL, V36, P32, DOI 10.2310/7070.2006.0061 HOTCHKISS JA, 1992, TOXICOL APPL PHARM, V114, P182, DOI 10.1016/0041-008X(92)90067-3 Jam KK, 1999, TXB HYPERBARIC MED KIRBY SD, 1999, CURR OPIN OTOLARYNGO, V7, P137, DOI 10.1097/00020840-199906000-00008 Mantell LL, 1999, ANN NY ACAD SCI, V887, P171 MCDERMOTT JJ, 1992, UNDERSEA BIOMED RES, V19, P403 Moon RE, 1997, AVIAT SPACE ENVIR MD, V68, P234 Narozny W, 2002, CLIN OTOLARYNGOL, V27, P140, DOI 10.1046/j.1365-2273.2002.00548.x Neovius EB, 1997, HEAD NECK-J SCI SPEC, V19, P315, DOI 10.1002/(SICI)1097-0347(199707)19:4<315::AID-HED10>3.0.CO;2-8 Neumeister M, 2004, HYPERBARIC OXYGEN TH Nikasinovic L, 2003, J TOXICOL ENV HEAL B, V6, P521, DOI 10.1080/10937400306477 NIKULA KJ, 1991, FUND APPL TOXICOL, V17, P675, DOI 10.1016/0272-0590(91)90177-6 Pacini S, 2003, ENVIRON MOL MUTAGEN, V42, P127, DOI 10.1002/em.10188 Racic G, 2003, ORL J OTO-RHINO-LARY, V65, P317, DOI 10.1159/000076048 Roper JM, 2004, AM J PHYSIOL-LUNG C, V286, pL1045, DOI 10.1152/ajplung.00376.2003 Sahni T, 2004, MED UPDATE, V14, P632 Schierhorn K, 2002, INT ARCH ALLERGY IMM, V129, P145, DOI 10.1159/000065879 Schrodter S, 2004, RHINOLOGY, V42, P153 Stanek A, 1998, BRIT J ANAESTH, V80, P660 Topuz E, 2004, EUR ARCH OTO-RHINO-L, V261, P393, DOI 10.1007/s00405-003-0688-6 NR 32 TC 5 Z9 5 PU INT RHINOLOGIC SOC PI UTRECHT PA UNIV MEDICAL CENTER UTRECHT, RM G05 127, DEPT OTORHINOL, HEIDELBERGLAAN 100, 3584 CX UTRECHT, NETHERLANDS SN 0300-0729 J9 RHINOLOGY JI Rhinology PD DEC PY 2008 VL 46 IS 4 BP 297 EP 301 PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA 383VE UT WOS:000261701500010 PM 19146000 ER PT J AU Offergeld, C Schellong, S Schmidt, A Pfaar, O Steigerwald, C Zahnert, T AF Offergeld, C. Schellong, S. Schmidt, A. Pfaar, O. Steigerwald, C. Zahnert, T. TI Diagnostic Value of Color-Coded, Doppler Sonography in Neuro-Otologic Disorders SO ULTRASCHALL IN DER MEDIZIN LA German DT Article DE ultrasound color doppler; hearing loss; inner ear functional disorder; extracranial brain-supplying vessels; atherosclerosis ID SENSORINEURAL HEARING-LOSS; SUDDEN DEAFNESS; BLOOD-FLOW; THERAPY; ULTRASONOGRAPHY; ARTERIES AB Purpose: The successful introduction of Doppler and Color-Coded Doppler Sonography (CCDS) in the field of Otorhinolaryngology has improved the diagnostic sonographic value for several diseases of the head and neck region, e.g. in hemangiomas and vascular malformations. The diagnostic value of CCDS for examination of the extracranial brain supplying vessels in combination with neuro-otologic disorders is still under controversial discussion. Materials and Methods: We investigated the diagnostic CCDS findings for 215 patients Suffering from different neuro-otologic disorders. All patients were classified into 4 groups according to the different disorder entity (sudden deafness, tinnitus, vestibular neuropathy, combined diagnosis). The frequency of pathologic CCDS findings was correlated with the different groups using sonographic parameters such as atherosclerosis, stenosis and intima-media thickness. Results: Classification of the disorder entities led to the following distribution: Sudden deafness group (85 patients; 40%), Tinnitus group (44 patients 20%), Vestibular neuropathy group (41 patients; 19%), Combined diagnosis group (45 patients; 21%). Sonographic evaluation of atherosclerosis was possible in 76 cases (35%), changes of the intima-media thickness were observed in 43 cases (20%) while proof of stenoses was identified in 15 cases (7%). The evaluation of plaque formation (atherosclerosis) in the Sudden deafness group was significantly higher (p < 0.01) than in all other groups although the combined diagnosis group demonstrated certain tendencies (p < 0.08) without significant correlation. Conclusion: Our results reinforce the hypothesis of a vascular genesis of sudden deafness and seem to offer the possibility of sonographic differentiation between neuro-otologic disorder entities by use of CCDS. In contrast, it seems that the role of CCDS is negligible for individual diagnostic purposes. C1 [Offergeld, C.; Steigerwald, C.] Univ Klin Freiburg, Univ HNO Klin, D-79106 Freiburg, Germany. [Schellong, S.] Med Univ Klin III Dresden, Arbeitsbereich Angiol, Dresden, Germany. [Schmidt, A.] Herzzentrum Univ Leipzig, Leipzig, Germany. [Pfaar, O.] Zentrum Rhinol & Allergol, HNO Abt, Wiesbaden, Germany. [Zahnert, T.] Univ Klinikum Dresden, Univ HNO Klin, Dresden, Germany. RP Offergeld, C (reprint author), Univ Klin Freiburg, Univ HNO Klin, Killianstr 5, D-79106 Freiburg, Germany. 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PD DEC PY 2008 VL 29 IS 6 BP 627 EP 632 DI 10.1055/s-2007-963415 PG 6 WC Acoustics; Radiology, Nuclear Medicine & Medical Imaging SC Acoustics; Radiology, Nuclear Medicine & Medical Imaging GA 403GY UT WOS:000263072300007 PM 18213546 ER PT J AU Hasegawa, K Murakami, S Kurosaki, M Kunimoto, Y Ogawa, T Kitano, H AF Hasegawa, Kensaku Murakami, Shingo Kurosaki, Masamichi Kunimoto, Yasuomi Ogawa, Toshihide Kitano, Hiroya TI Endolymphatic Sac Tumor, A Patient Report SO YONAGO ACTA MEDICA LA English DT Article DE endolymphatic sac tumor; pathologic diagnosis; temporal bone surgery; 3-tesla magnetic resonance imaging ID HIPPEL-LINDAU DISEASE; MIDDLE-EAR; PAPILLARY ADENOCARCINOMA; TEMPORAL BONE; ADENOMA AB Endolymphatic sac tumors are rare low malignant neoplasms of the petrous temporal bone, with symptoms referable to auditory, vestibular or facial nerves, which should be strictly discriminated from benign tumors of the temporal bone. Differential diagnosis between both at the early stages of checkup controls the treatment and prognosis. Complete surgical resection is the treatment of choice, which commonly provides long-term control. We have experienced a 48-year-old man with progressive hearing loss, unsteadiness and constant tinnitus. Computed tomography and magnetic resonance imaging (MRI) demonstrated a tumor invading the posterior petrous bone, extending to the posterior fossa. In the course of image diagnosis of his disease, we observed diagnostic efficacy of 3-tesla MRI, which showed excellent lesion visualization even in a small-size endolymphatic sac tumor. The intraoperative pathologic diagnosis was not available. C1 [Hasegawa, Kensaku; Kunimoto, Yasuomi; Kitano, Hiroya] Tottori Univ, Fac Med, Div Otolaryngol Head & Neck Surg, Dept Med Sensory & Motor Organs,Sch Med, Yonago, Tottori 6838504, Japan. [Murakami, Shingo] Nagoya City Univ, Grad Sch Med Sci, Dept Neurootolaryngol Sensory & Plast Med, Nagoya, Aichi 4670601, Japan. [Kurosaki, Masamichi] Tottori Univ, Fac Med, Dept Neurosurg, Inst Neurol Sci, Yonago, Tottori 6838504, Japan. [Ogawa, Toshihide] Tottori Univ, Fac Med, Dept Pathophysiol & Therapeut Sci, Div Radiol,Sch Med, Yonago, Tottori 6838504, Japan. RP Hasegawa, K (reprint author), Tottori Univ, Fac Med, Div Otolaryngol Head & Neck Surg, Dept Med Sensory & Motor Organs,Sch Med, Yonago, Tottori 6838504, Japan. 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PD DEC PY 2008 VL 51 IS 4 BP 101 EP 106 PG 6 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA 400DM UT WOS:000262848200002 ER PT J AU Wyatt, C AF Wyatt, Charles TI 'Tinnitus' SO LITERARY REVIEW LA English DT Poetry NR 0 TC 0 Z9 0 PU FAIRLEIGH DICKINSON UNIV LITERARY REV PI MADISON PA 285 MADISON AVE, MADISON, NJ 07940 USA SN 0024-4589 J9 LITERARY REV JI Lit. Rev. PD WIN PY 2008 VL 51 IS 2 BP 104 EP 105 PG 2 WC Literary Reviews SC Literature GA 272VI UT WOS:000253888400023 ER PT J AU Schlee, W Weisz, N Bertrand, O Hartmann, T Elbert, T AF Schlee, Winfried Weisz, Nathan Bertrand, Olivier Hartmann, Thomas Elbert, Thomas TI Using Auditory Steady State Responses to Outline the Functional Connectivity in the Tinnitus Brain SO PLOS ONE LA English DT Article AB Background: Tinnitus is an auditory phantom perception that is most likely generated in the central nervous system. Most of the tinnitus research has concentrated on the auditory system. However, it was suggested recently that also non-auditory structures are involved in a global network that encodes subjective tinnitus. We tested this assumption using auditory steady state responses to entrain the tinnitus network and investigated long-range functional connectivity across various non-auditory brain regions. Methods and Findings: Using whole-head magnetoencephalography we investigated cortical connectivity by means of phase synchronization in tinnitus subjects and healthy controls. We found evidence for a deviating pattern of long-range functional connectivity in tinnitus that was strongly correlated with individual ratings of the tinnitus percept. Phase couplings between the anterior cingulum and the right frontal lobe and phase couplings between the anterior cingulum and the right parietal lobe showed significant condition x group interactions and were correlated with the individual tinnitus distress ratings only in the tinnitus condition and not in the control conditions. Conclusions: To the best of our knowledge this is the first study that demonstrates existence of a global tinnitus network of long-range cortical connections outside the central auditory system. This result extends the current knowledge of how tinnitus is generated in the brain. We propose that this global extend of the tinnitus network is crucial for the continuos perception of the tinnitus tone and a therapeutical intervention that is able to change this network should result in relief of tinnitus. C1 [Schlee, Winfried; Weisz, Nathan; Hartmann, Thomas; Elbert, Thomas] Univ Konstanz, Dept Psychol, Constance, Germany. [Weisz, Nathan; Bertrand, Olivier] INSERM, U821, Lyon, France. RP Schlee, W (reprint author), Univ Konstanz, Dept Psychol, Constance, Germany. 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They are listed as a novel clinico-pathological entity in the 2007 World Health Organisation (WHO) classification of tumours of the central nervous system. This tumour corresponds to a WHO grade II neoplasm whereas pilocytic astrocytoma corresponds to WHO grade I. We have encountered an infratentorial tumour with pilomyxoid features in an adult. A 25 year old man presented with tinnitus and hyperacusis. Brain MRI revealed a mass occupying the fourth ventricle. We performed partial resection, but no adjuvant therapy was given. The staining index for the anti-Ki-67 monoclonal antibody MIB-1 was less than 1% in this patient. Pilomyxoid astrocytomas are not limited to the hypothalamic/chiasmatic region in children. Additional knowledge and recognition of this entity is necessary to improve treatment of pilomyxoid astrocytoma. C1 [Omura, Tomoko; Nawashiro, Hiroshi; Osada, Hideo; Shima, Katsuji] Natl Def Med Coll, Dept Neurosurg, Tokorozawa, Saitama 3598513, Japan. [Tsuda, Hitoshi] Natl Def Med Coll, Dept Basic Pathol, Tokorozawa, Saitama 3598513, Japan. [Shinsuke, Aida] Natl Def Med Coll, Dept Lab Med, Tokorozawa, Saitama 3598513, Japan. RP Nawashiro, H (reprint author), Natl Def Med Coll, Dept Neurosurg, 3-2 Namiki, Tokorozawa, Saitama 3598513, Japan. 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PD NOV PY 2008 VL 150 IS 11 BP 1203 EP 1206 DI 10.1007/s00701-008-0032-4 PG 4 WC Clinical Neurology; Surgery SC Neurosciences & Neurology; Surgery GA 371MG UT WOS:000260834800013 PM 18958385 ER PT J AU Hanley, PJ Davis, PB Paki, B Quinn, SA Bellekorn, SR AF Hanley, Peter J. Davis, Paul B. Paki, Bardia Quinn, Shaunine A. Bellekorn, Sandra R. TI Treatment of Tinnitus With a Customized, Dynamic Acoustic Neural Stimulus: Clinical Outcomes in General Private Practice SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE acoustic stimulation; cohort study; rehabilitation; tinnitus ID MANAGEMENT; THERAPY; TRIAL AB Objectives: We evaluate the relative effectiveness of a newly available tinnitus treatment approach for different categories of patients in general private, practice. Methods: This was a cohort study, sponsored by Neuromonics, involving the first 470 patients to undertake the Neuromonics Tinnitus Treatment in 1 Neuromonics tinnitus clinics. All patients were provided with a dynamic acoustic neural stimulus, customized to each patient's audiometric profile, for daily use as part of a structured rehabilitation program. Tinnitus disturbance was assessed before, during, and after treatment with the Tinnitus Reaction Questionnaire. Results: The outcomes displayed a relation with patients' suitability according to predefined criteria: among the most suitable patients (tier 1 cohort), 92% exceeded the threshold for success (defined as a reduction in tinnitus-related disturbance of at least 40%), and the mean improvement in tinnitus disturbance was 72%; the discontinuance rate was 4%. For other suitability categories, the success rates and mean improvements were somewhat lower, and the discontinuance rates higher (tier 2: 60%, 49%, and 16%, respectively; tier 3: 39%, 32%, and 17%, respectively). Conclusions: The results showed that the treatment is effective for suitable patients in the private practice setting, and they provide health-care professionals with guidance as to what patients might expect from treatment, depending on their degree of suitability. C1 [Hanley, Peter J.; Davis, Paul B.; Paki, Bardia; Quinn, Shaunine A.; Bellekorn, Sandra R.] Neuromon Pty Ltd, Chatswood, NSW 2067, Australia. RP Hanley, PJ (reprint author), Neuromon Pty Ltd, Level 2,12 Thomas St, Chatswood, NSW 2067, Australia. 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Otol. Rhinol. Laryngol. PD NOV PY 2008 VL 117 IS 11 BP 791 EP 799 PG 9 WC Otorhinolaryngology SC Otorhinolaryngology GA 374TO UT WOS:000261066800001 PM 19102123 ER PT J AU Lopez-Ibor, JJ Lopez-Ibor, MI Pastrana, JI AF Lopez-Ibor, Juan J. Lopez-Ibor, Maria-Ines Pastrana, Jose I. TI Transcranial magnetic stimulation SO CURRENT OPINION IN PSYCHIATRY LA English DT Article DE attention-deficit disorder with hyperactivity; auditory hallucinations; dorsolateral prefrontal cortex; posttraumatic stress disorder; repeated transcranial magnetic stimulation; transcranial magnetic stimulation; treatment-resistant depression ID DORSOLATERAL PREFRONTAL CORTEX; RESISTANT MAJOR DEPRESSION; OBSESSIVE-COMPULSIVE DISORDER; DOUBLE-BLIND; AUDITORY HALLUCINATIONS; CORTICAL EXCITABILITY; CONTROLLED-TRIAL; HEALTHY-VOLUNTEERS; SCHIZOPHRENIA; RTMS AB Purpose of review To present state-of-the-art transcranial magnetic stimulation (TMS) therapy, especially when it is used in psychiatric disorders, on the basis of an exhaustive literature search from 2006 to date (June 2008) on TMS papers published in Medline and Embase. Other references and comments from our own experience started 8 years ago have also been taken into account. Recent findings The mechanism of action of TMS is now better understood. There is strong evidence of the safety and tolerability of TMS when standard protocols are used. The efficacy of the stimulation of the dorsolateral prefrontal cortex in depression is well documented, and there is evidence of the utility of TMS in posttraumatic stress disorder, in persistent auditory hallucinations in schizophrenia and in attention-deficit disorder with hyperactivity. Summary There is enough evidence of the efficacy and safety of TMS in depression to include this technique in the therapeutic protocols of major depression. However, more research is needed on the use of this technique in other psychiatric and nonpsychiatric disorders such as posttraumatic stress disorder, persistent auditory hallucinations, attention-deficit disorder with hyperactivity and tinnitus. C1 [Lopez-Ibor, Juan J.; Lopez-Ibor, Maria-Ines] Univ Complutense, Dept Psychiat, E-28040 Madrid, Spain. [Lopez-Ibor, Juan J.] San Carlos Univ Hosp, Psychiat & Mental Hlth Inst, Madrid, Spain. [Pastrana, Jose I.] Clin Lopez Ibor, Madrid, Spain. RP Lopez-Ibor, JJ (reprint author), Doctor Juan Jose Lopez Ibor 2, Madrid 28035, Spain. 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Opin. Psychiatr. PD NOV PY 2008 VL 21 IS 6 BP 640 EP 644 DI 10.1097/YCO.0b013e3283136a0c PG 5 WC Psychiatry SC Psychiatry GA 371GL UT WOS:000260819700019 PM 18852574 ER PT J AU Brookler, KH Hamid, MA AF Brookler, Kenneth H. Hamid, Mohamed A. TI An approach to tinnitus management SO ENT-EAR NOSE & THROAT JOURNAL LA English DT Editorial Material C1 [Brookler, Kenneth H.] Neurotol Associates, PC, New York, NY USA. [Hamid, Mohamed A.] Cleveland Hearing & Balance Ctr, Beachwood, OH USA. RP Brookler, KH (reprint author), Neurotol Associates, PC, New York, NY USA. CR Kraft JR, 1998, INT TINNITUS J, V4, P127 NR 1 TC 1 Z9 1 PU VENDOME GROUP LLC PI NEW YORK PA 149 FIFTH AVE, 10TH FLOOR, NEW YORK, NY 10010 USA SN 0145-5613 J9 ENT-EAR NOSE THROAT JI ENT-Ear Nose Throat J. PD NOV PY 2008 VL 87 IS 11 BP 616 EP + PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA V10PE UT WOS:000207475100004 PM 19006060 ER PT J AU Savastano, M AF Savastano, Marina TI Tinnitus with or without hearing loss: are its characteristics different? SO EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY LA English DT Article DE tinnitus; normal hearing; hearing loss ID MECHANISMS AB The present study was carried out in order to analyze the clinical characteristics of tinnitus both in normal hearing subjects and in patients with hearing loss. The study considered 520 consecutive tinnitus sufferers. The following parameters were considered: age, sex, subjective disturbance caused by tinnitus, subjective judgment of tinnitus intensity, tinnitus laterality, tinnitus duration, tinnitus measurements, normal hearing or associated hearing loss. Among the patients considered, 223 have normal hearing while 297 have a hearing deficit. The hearing impairment was found to be in most cases of sensorineural type. The subjective discomfort is higher in presence of hearing loss. Subjects with hearing loss needed significantly higher masking levels. No evident differences in the residual inhibition (RI) result between the two groups were found. The present study confirms that tinnitus is most frequently associated with hearing loss. The characteristics of tinnitus in normal hearing subjects, except for the subjective judgment of tinnitus intensity, the pitch and the RI, are significantly different for those observed in subjects with hearing loss. The association of tinnitus and hearing deficit seems to increase the perceived severity of the symptom. C1 Univ Padua, Dept Med Surg Special, ENT Sect, I-35128 Padua, Italy. RP Savastano, M (reprint author), Univ Padua, Dept Med Surg Special, ENT Sect, Via Giustiniani 2, I-35128 Padua, Italy. 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TI Interferon-alpha-2b/ribavirin-induced vestibulocochlear toxicity with dysautonomia in a chronic hepatitis C patient SO EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY LA English DT Article DE autonomic neuropathy; hearing loss; hepatitis C virus; interferon-alpha; ribavirin; tinnitus; vertigo; vestibulocochlear toxicity ID SUDDEN HEARING-LOSS; INTERFERON-ALPHA; VIRUS-INFECTION; RIBAVIRIN; THERAPY; EXACERBATION; NEUROPATHY; CRYOGLOBULINEMIA; COMBINATION; HEMOLYSIS AB A 57-year-old man developed vertigo, tinnitus, bilateral hearing loss and postural intolerance temporally related to the administration of pegylated interferon-alpha-2b/ribavirin for chronic hepatitis C viral infection. Clinical examination showed bilateral sensorineural hearing loss, subjective vertigo with saccadic intrusions during fixation and smooth visual pursuit, and supine hypertension followed by orthostatic hypotension with inadequate reflexive compensatory cardiovascular responses. Laboratory assessment showed marked hemolytic anemia. Formal audiometry revealed high-frequency sensorineural hearing loss with abnormal high-frequency distortion product otoacoustic emissions, indicative of damage to the cochlear outer hair cells. Cessation of therapy resulted in rapid clinical resolution with mild residual hearing loss and tinnitus. This case report illustrates vestibulocochlear and autonomic nervous system adverse effects of pegylated interferon-alpha-2b/ribavirin, emphasizing the importance of early recognition and cessation of therapy to prevent permanent neurootologic injury. Eur J Gastroenterol Hepatol 20:1110-1114 (C) 2008 Wolters Kluwer Health | Lippincott Williams & Wilkins. C1 [Sargent, Lisa A.; Galizio, Christopher] Case Western Reserve Univ, Sch Med, Vet Affairs Med Ctr, Audiol Serv,Louis Stokes Cleveland Dept, Cleveland, OH USA. [Johnson, Kristin; Ubogu, Eroboghene E.] Case Western Reserve Univ, Sch Med, Vet Affairs Med Ctr, Neurol Serv,Louis Stokes Cleveland Dept, Cleveland, OH USA. RP Ubogu, EE (reprint author), Baylor Coll Med, Dept Neurol, 1 Baylor Plaza,MS NB302, Houston, TX 77030 USA. EM Ubogu@bcm.tmc.edu CR Arase Y, 2004, J GASTROENTEROL, V39, P1090, DOI 10.1007/s00535-004-1483-x Batisse D, 2004, EUR J GASTROEN HEPAT, V16, P701, DOI 10.1097/01.meg.0000108342.41221.0c Beuthien W, 2005, CLIN RHEUMATOL, V24, P507, DOI 10.1007/s10067-005-1093-x Biaggioni Italo, 2002, Cardiology Clinics, V20, P291, DOI 10.1016/S0733-8651(01)00005-4 Boonyapisit K, 2002, MUSCLE NERVE, V25, P909, DOI 10.1002/mus.10118 Briani C, 2006, NEUROLOGY, V67, P781, DOI 10.1212/01.wnl.0000233889.07772.76 Feld JJ, 2005, NATURE, V436, P967, DOI 10.1038/nature04082 Formann E, 2004, AM J GASTROENTEROL, V99, P873, DOI 10.1111/j.1572-0241.2004.30372.x Goldstein DS, 2003, HYPERTENSION, V42, P136, DOI 10.1161/01.HYP.0000081216.11623.C3 Irioka T, 2001, J NEUROL NEUROSUR PS, V70, P408, DOI 10.1136/jnnp.70.3.408 Jarvis SM, 1998, BRIT J PHARMACOL, V123, P1587, DOI 10.1038/sj.bjp.0701775 KANDA Y, 1995, AUDIOLOGY, V34, P98 LaCivita L, 1996, J RHEUMATOL, V23, P1641 Van Vlierberghe H, 2001, J HEPATOL, V34, P911, DOI 10.1016/S0168-8278(01)00029-0 LONSBURYMARTIN BL, 1995, OTOLARYNG HEAD NECK, V112, P50, DOI 10.1016/S0194-5998(95)70303-9 McHutchison JG, 1998, NEW ENGL J MED, V339, P1485, DOI 10.1056/NEJM199811193392101 Murofushi T, 1998, EUR ARCH OTO-RHINO-L, V255, P77, DOI 10.1007/s004050050023 Poynard T, 1998, LANCET, V352, P1426, DOI 10.1016/S0140-6736(98)07124-4 Tunca Ayşe, 2004, Turk J Gastroenterol, V15, P97 NR 19 TC 9 Z9 9 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0954-691X J9 EUR J GASTROEN HEPAT JI Eur. J. Gastroenterol. Hepatol. PD NOV PY 2008 VL 20 IS 11 BP 1110 EP 1114 DI 10.1097/MEG.0b013e3282f8e583 PG 5 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 369VC UT WOS:000260721000010 PM 19047844 ER PT J AU Vermeire, K Nobbe, A Schleich, P Nopp, P Voormolen, MH Van de Heyning, PH AF Vermeire, Katrien Nobbe, Andrea Schleich, Peter Nopp, Peter Voormolen, Maurits H. Van de Heyning, Paul H. TI Neural tonotopy in cochlear implants: An evaluation in unilateral cochlear implant patients with unilateral deafness and tinnitus SO HEARING RESEARCH LA English DT Article DE Single-sided deafness; Cochlear implants; Tonotopy; Greenwood ID PITCH PERCEPTION; RESIDUAL HEARING; EAR; MAP AB In cochlear implants, the signal is filtered into different frequency bands and transmitted to electrodes along the cochlea. In this study the frequency-place function for electric hearing was investigated as a means to possibly improve speech coding by delivering information to the appropriate cochlear place. Fourteen subjects with functional hearing in the contralateral ear have been provided with a MED-EL cochlear implant in the deaf ear in order to reduce intractable tinnitus. Pitch scaling experiments were performed using single-electrode, constant-amplitude, constant-rate stimuli in the implanted ear, and acoustic sinusoids in the contralateral ear. The frequency-place function was calculated using the electrode position in the cochlea as obtained from postoperative skull radiographs. Individual frequency-place functions were compared to Greenwood's function in normal hearing. Electric stimulation elicited a low pitch in the apical region of the cochlea, and shifting the stimulating electrode towards the basal region elicited increasingly higher pitch. The frequency-place function did not show a significant shift relative to Greenwood's function. In cochlear implant patients with functional hearing in the non-implanted ear, electrical stimulation produced a frequency-place function that on average resembles Greenwood's function. These results differ from previously derived data. (C) 2008 Elsevier B.V. All rights reserved. C1 [Vermeire, Katrien] Univ Innsbruck, Inst Ion Phys & Appl Phys, C Doppler Lab Act Implantable Syst, A-6020 Innsbruck, Austria. [Nobbe, Andrea; Schleich, Peter; Nopp, Peter] MED EL GmbH, A-6020 Innsbruck, Austria. [Voormolen, Maurits H.] Univ Antwerp, Univ Antwerp Hosp, Dept Radiol, B-2650 Edegem, Belgium. [Vermeire, Katrien; Van de Heyning, Paul H.] Univ Antwerp, Univ Antwerp Hosp, Dept Otorhinolaryngol & Head & Neck Surg, B-2650 Edegem, Belgium. RP Vermeire, K (reprint author), Univ Innsbruck, Inst Ion Phys & Appl Phys, C Doppler Lab Act Implantable Syst, Technikerstr 25, A-6020 Innsbruck, Austria. EM katrien.vermeire@uibk.ac.at; Andrea.nobbe@web.de; Peter.schleich@medel.com; Peter.nopp@medel.com; Maurits.voormolen@uza.be; Paul.van.de.heyning@uza.be CR Baumann U, 2006, HEARING RES, V213, P34, DOI 10.1016/j.heares.2005.12.010 Blamey PJ, 1996, HEARING RES, V99, P139, DOI 10.1016/S0378-5955(96)00095-0 Boex C, 2006, JARO-J ASSOC RES OTO, V7, P110, DOI 10.1007/s10162-005-0027-2 BUSBY PA, 1994, J ACOUST SOC AM, V95, P2658, DOI 10.1121/1.409835 Dorman MF, 2007, JARO-J ASSOC RES OTO, V8, P234, DOI 10.1007/s10162-007-0071-1 DORMAN MF, 1990, EAR HEARING, V11, P310, DOI 10.1097/00003446-199008000-00010 DORMAN MF, 1994, J ACOUST SOC AM, V95, P1677, DOI 10.1121/1.408558 Eddington D K, 1978, Ann Otol Rhinol Laryngol, V87, P1 GREENWOOD D, 1961, J ACOUST SOC AM, V33, P1344, DOI 10.1121/1.1908437 GREENWOOD DD, 1990, J ACOUST SOC AM, V87, P2592, DOI 10.1121/1.399052 James C, 2001, AUDIOL NEURO-OTOL, V6, P87, DOI 10.1159/000046814 Kawano A, 1996, ANN OTO RHINOL LARYN, V105, P701 MCDERMOTT H, AUDIO NEURO IN PRESS Oxenham AJ, 2004, P NATL ACAD SCI USA, V101, P1421, DOI 10.1073/pnas.0306958101 Sridhar Divya, 2006, Audiol Neurootol, V11 Suppl 1, P16, DOI 10.1159/000095609 Stakhovskaya O, 2007, JARO-J ASSOC RES OTO, V8, P220, DOI 10.1007/s10162-007-0076-9 TOWNSHEND B, 1987, J ACOUST SOC AM, V82, P106, DOI 10.1121/1.395554 Van de Heyning Paul, 2008, Ann Otol Rhinol Laryngol, V117, P645 VERMEIRE K, AUDIO NEURO IN PRESS Vinay, 2007, EAR HEARING, V28, P231 Xu J, 2000, AM J OTOL, V21, P49, DOI 10.1016/S0196-0709(00)80112-X NR 21 TC 23 Z9 25 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-5955 J9 HEARING RES JI Hear. Res. PD NOV PY 2008 VL 245 IS 1-2 BP 98 EP 106 DI 10.1016/j.heares.2008.09.003 PG 9 WC Audiology & Speech-Language Pathology; Neurosciences; Otorhinolaryngology SC Audiology & Speech-Language Pathology; Neurosciences & Neurology; Otorhinolaryngology GA 381WD UT WOS:000261565700013 PM 18817861 ER PT J AU Bakar, B AF Bakar, Bulent TI The Jugular Foramen Schwannomas: Review of the Large Surgical Series SO JOURNAL OF KOREAN NEUROSURGICAL SOCIETY LA English DT Review DE Cranial nerve; Schwannoma; Skull base tumors; Surgery; Jugular foramen ID NERVE SHEATH TUMORS; MANAGEMENT; DIAGNOSIS AB Objective : Jugular foramen schwannomas are uncommon pathological conditions. This article is constituted for screening these tumors in a wide perspective. Materials : One-hundred-and-ninty-nine patients published in 19 articles between 1984 to 2007 years was collected from Medline/Index Medicus. Results : The series consist of 83 male and 98 female. The mean age of 199 operated patients was 40.4 years. The lesion located on the right side in 32 patients and on the left side in 60 patients. The most common presenting clinical symptoms were hearing loss, tinnitus, disphagia, ataxia, and hoarseness. Complete tumor removal was achieved in 159 patients. In fourteen patients tumor reappeared unexpectedly. The tumor was thought to originate from the glossopharyngeal nerve in forty seven cases; vagal nerve in twenty six cases; and cranial accessory nerve in eleven cases. The most common postoperative complications were lower cranial nerve palsy and facial nerve palsy. Cerebrospinal fluid leakage, meningitis, aspiration pneumonia and mastoiditis were seen as other complications. Conclusion : This review shows that jugular foramen schwannomas still have prominently high morbidity and those complications caused by postoperative lower cranial nerve injury are life threat. C1 MESA Hosp, Dept Neurosurg, TR-06510 Ankara, Turkey. 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Korean. Neurosurg. Soc. PD NOV PY 2008 VL 44 IS 5 BP 285 EP 294 DI 10.3340/jkns.2008.44.5.285 PG 10 WC Clinical Neurology; Surgery SC Neurosciences & Neurology; Surgery GA 380ND UT WOS:000261471500001 PM 19119464 ER PT J AU Lee, WS Koo, JW AF Lee, Won Sang Koo, Ja-Won TI Meniere's Disease SO JOURNAL OF THE KOREAN MEDICAL ASSOCIATION LA Korean DT Article DE Meniere's disease; Endolymphatic hydrops; Dizziness; Hearing loss ID II COLLAGEN AUTOIMMUNITY; ENDOLYMPHATIC HYDROPS; VESTIBULAR AQUEDUCT; INNER-EAR; SAC; PATHOGENESIS; MEMBRANE; SYMPTOMS AB Hydrops of the endolymphatic space in the inner ear deteriorates hearing and balance function. This idiopathic syndrome of endolymphatic hydrops is Meniere's disease and is characterized by episodic vertigo, fluctuating hearing loss, tinnitus and ear fullness. For the pathophysiologic mechanisms of the episode, the progression of the hydrops leads to ruptures in the membranes separating endolymph from perilymph, producing a sudden increase in potassium concentration in the perilymph. Recurrent episodes may interfere with routine daily activities and sometimes accompany sudden drop attacks, so called Tumarkin's otolithic crisis, which may lead to serious injuries. Life style modification, low salt diet and prescription of diuretics have been traditionally tried in order to relieve endolymphatic hydrops. Surgical and destructive treatment options are necessary in selected intractable patients depending on the frequency of vertigo, severity of hearing loss and the possibility of bilateral involvement. However, a large proportion of these patients shows a spontaneous cure of vertigo with the aggravation of hearing loss (burnt out stage) over time. The goal of treatment is trying not to make the patient worse than this natural course of disease. 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PD NOV PY 2008 VL 87 IS 11 BP 805 EP 808 DI 10.1055/s-2008-1077674 PG 4 WC Otorhinolaryngology SC Otorhinolaryngology GA 375MG UT WOS:000261117400011 PM 18975247 ER PT J AU Coelho, DH Roland, JT Rush, SA Narayana, A Clair, ES Chung, W Golfinos, JG AF Coelho, Daniel H. Roland, J. Thomas, Jr. Rush, Stephen A. Narayana, Ashwatha Clair, Eric St. Chung, Wayne Golfinos, John G. TI Small Vestibular Schwannomas With No Hearing: Comparison of Functional Outcomes in Stereotactic Radiosurgery and Microsurgery SO LARYNGOSCOPE LA English DT Article DE Vestibular schwannoma; acoustic neuroma; stereotactic radiosurgery; microsurgery; disequilibrium; imbalance; vertigo; gamma knife ID GAMMA-KNIFE RADIOSURGERY; ACOUSTIC NEUROMA SURGERY; QUALITY-OF-LIFE; FOLLOW-UP; MANAGEMENT; RADIOTHERAPY; RADIATION; RESECTION; REMOVAL; VERTIGO AB Objectives: To date, numerous studies have compared functional outcomes between stereotactic-radiosurgery (SRS) and microsurgery (MS) in the treatment of vestibular schwannomas (VS). However, most of them involve tumors of difference size, radiation dosages and surgical approaches. Few have systematically compared issues of dysequilibrium. By studying only patients with small tumors and no hearing, we sought to minimize confounding variables. Study Design: A retrospective chart review and telephone questionnaire. Methods: From 1998-2006, 31 patients with small (<1.5 cm) Vs and nonserviceable hearing (American Academy of Otolaryngology-Head and Neck surgery [AAO HNS] Class C or D were treated at our institution. Twenty-two were available for followup and telephone questionnaire including the University of California, Los Angeles Dizziness Questionnaire (UCLA DQ). Twelve underwent SRS and 10 underwent MS. All MS patients underwent the translabyrinthine approach to their tumors. Outcomes measurements included tumor control, facial nerve function, tinnitus, trigeminal function, and imbalance. Results: Patients undergoing SRS had comparable rates of tumor control, facial nerve function, tinnitus, and trigeminal function to MS patients. However, SRS did result in statistically significantly worse long-term imbalance when compared with MS patients. Detailed comparisons of the two modalities are made. Conclusions: In our study population patients with small tumors and no serviceable hearing these data suggest that MS results in comparable minimal morbidity with SRS, though post treatment dysequilibrium is significantly decreased. While the authors recommend translabyrinthine resection of small Vs with no hearing in patients able to tolerate surgery the need for further prospective investigation is clear. C1 [Roland, J. Thomas, Jr.] NYU, Dept Otolaryngol, Div Otol Neurotol, Sch Med, New York, NY 10016 USA. [Roland, J. Thomas, Jr.; Clair, Eric St.; Golfinos, John G.] NYU, Dept Neurosurg, Sch Med, New York, NY 10016 USA. [Rush, Stephen A.; Narayana, Ashwatha; Golfinos, John G.] NYU, Dept Radiat Oncol, Sch Med, New York, NY 10016 USA. [Coelho, Daniel H.] Virginia Commonwealth Univ, Dept Otolaryngol Head & Neck Surg, Richmond, VA USA. RP Roland, JT (reprint author), NYU, Dept Otolaryngol, Div Otol Neurotol, Sch Med, 550 1St Ave,Suite 8S, New York, NY 10016 USA. 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[Lee, Tae-Hong] Pusan Natl Univ, Dept Diagnost Radiol, Sch Med, Pusan 602739, South Korea. RP Goh, EK (reprint author), Pusan Natl Univ, Dept Otorhinolaryngol, Sch Med, 1-10 Ami Dong, Pusan 602739, South Korea. EM gohek@pusan.ac.kr FU Pusan National University Research FX This work was supported for two years by a Pusan National University Research Grant. CR Kondoh K, 2004, ANN OTO RHINOL LARYN, V113, P975 Lavine Sean D, 2007, Clin Neurosurg, V54, P64 Page JR, 1914, ANN OTO RHINOL LARYN, V23, P161 Phatouros CC, 2000, NEUROSURGERY, V47, P107, DOI 10.1097/00006123-200007000-00023 Zenteno M, 2004, J NEUROSURG, V100, P120, DOI 10.3171/jns.2004.100.1.0120 NR 5 TC 8 Z9 10 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0194-5998 J9 OTOLARYNG HEAD NECK JI Otolaryngol. Head Neck Surg. PD NOV PY 2008 VL 139 IS 5 BP 740 EP 741 DI 10.1016/j.otohns.2008.04.019 PG 2 WC Otorhinolaryngology; Surgery SC Otorhinolaryngology; Surgery GA 369UR UT WOS:000260719900028 PM 18984278 ER PT J AU Sun, W Zhang, L Lu, J Yang, G Laundrie, E Salvi, R AF Sun, W. Zhang, L. Lu, J. Yang, G. Laundrie, E. Salvi, R. TI Noise exposure-induced enhancement of auditory cortex response and changes in gene expression SO NEUROSCIENCE LA English DT Article DE auditory cortex; gene expression; heat shock protein; noise exposure; gene microarray; tinnitus ID INFERIOR COLLICULUS; RAT-BRAIN; EVOKED-RESPONSES; ACOUSTIC TRAUMA; COCHLEAR DAMAGE; ALBINO-RAT; TINNITUS; NEURONS; STRESS; APOPTOSIS AB Noise exposure is one of the most common causes of hearing loss. There is growing evidence suggesting that noise-induced peripheral hearing loss can also induce functional changes in the central auditory system. However, the physiological and biological changes in the central auditory system induced by noise exposure are poorly understood. To address these issues, neurophysiological recordings were made from the auditory cortex (AC) of awake rats using chronically implanted electrodes before and after acoustic overstimulation. In addition, focused gene microarrays and quantitative real-time polymerase chain reaction were used to identify changes in gene expression in the AC. Monaural noise exposure (120 dB sound pressure level, 1 h) significantly elevated hearing threshold on the exposed ear and induced a transient enhancement on the AC response amplitude 4 h after the noise exposure recorded from the unexposed ear. This increase of the cortical neural response amplitude was associated with an upregulation of genes encoding heat shock protein (HSP) 27 kDa and 70 kDa after several hours of the noise exposure. These results suggest that noise exposure can induce a fast physiological change in the AC which may be related to the changes of HSP expressions. Published by Elsevier Ltd on behalf of IBRO. C1 [Sun, W.; Zhang, L.; Lu, J.; Yang, G.; Laundrie, E.; Salvi, R.] SUNY Buffalo, Ctr Hearing & Deafness, Buffalo, NY 14214 USA. [Sun, W.; Salvi, R.] SUNY Buffalo, Dept Communicat Disorders & Sci, Buffalo, NY 14214 USA. RP Sun, W (reprint author), SUNY Buffalo, Ctr Hearing & Deafness, 137 Cary Hall,3435 Main St, Buffalo, NY 14214 USA. EM weisun@buffalo.edu FU National Institutes of Health [DC008685-01, DC009091, DC009219] FX We want to thank Dr. James Samson and Dr. Kari Suzanne Kraus for reading the manuscript and providing very helpful comments. We also want to thank Dr. Brazeau and Diane Letina in Department of Pharmaceutical Sciences of the University at Buffalo for providing technical support on this study. This project is supported by grants from National Institutes of Health (DC008685-01 to W.S., DC009091 and DC009219 to R.S.). 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Celik, H. Akpek, S. Oner, Y. Gumus, T. Tokgoz, N. TI Vascular Loops at the Cerebellopontine Angle: Is There a Correlation with Tinnitus? SO AMERICAN JOURNAL OF NEURORADIOLOGY LA English DT Article; Proceedings Paper CT 44th Annual Meeting of the American-Society-of-Neuroradiology CY APR 29-MAY 05, 2006 CL San Diego, CA SP Amer Soc Neuroradiol ID INFERIOR CEREBELLAR ARTERY; NEUROVASCULAR COMPRESSION SYNDROME; 8TH CRANIAL NERVE; PULSATILE TINNITUS; HEMIFACIAL SPASM; SYMPTOMS; EXPLAIN AB BACKGROUND AND PURPOSE: Tinnitus is a common disorder, and the etiology remains mostly unclear. The purpose of this study was to investigate the causative effect of the vascular loop and compression of the vestibulocochlear nerve at the cerebellopontine angle in patients with unexplained tinnitus. MATERIALS AND METHODS: This study was approved by our institutional review board. Written informed consent was obtained from all participants. Fifty-eight patients with unexplained tinnitus and 44 age- and sex-matched asymptomatic controls were examined with temporal MR imaging. Besides the tinnitus and control groups, a third group was formed by asymptomatic sides of patients with unilateral tinnitus. A 3D fast imaging employing steady-state acquisition (3D-FIESTA) sequence was performed in addition to the regular pre- and postcontrast axial and coronal sequences. The anatomic type of vascular loop, the vascular contact, and the angulation of the vestibulocochlear nerve at the cerebellopontine angle (CPA) were evaluated by 2 experienced neuroradiologists. The chi(2) test was used for statistical analysis. RESULTS: No statistically significant differences were found between the patient and control groups for the anatomic type of vascular loop, the vascular contact, and the angulation of the vestibulocochlear nerve at the CPA (P > .05). CONCLUSION: Although 3D-FIESTA MR imaging correctly shows the anatomic relationships of the vestibulocochlear nerve, its vascular compression cannot be attributed as an etiological factor for tinnitus. C1 [Gultelkin, S.; Celik, H.; Akpek, S.; Oner, Y.; Gumus, T.; Tokgoz, N.] Gazi Univ, Sch Med, Dept Radiol, TR-06510 Besevler, Turkey. RP Gultelkin, S (reprint author), Gazi Univ, Sch Med, Dept Radiol, TR-06510 Besevler, Turkey. 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J. Neuroradiol. PD OCT PY 2008 VL 29 IS 9 BP 1746 EP 1749 DI 10.3174/ajnr.A1212 PG 4 WC Clinical Neurology; Neuroimaging; Radiology, Nuclear Medicine & Medical Imaging SC Neurosciences & Neurology; Radiology, Nuclear Medicine & Medical Imaging GA 359YI UT WOS:000260023800027 PM 18653684 ER PT J AU Lee, CY Shih, YY Jaw, FS AF Lee, Chung-Yi Shih, Yen-Yu Jaw, Fu-Shan TI HOW TO EXTRACT THE SPATIAL CORRELATION OF AUDITORY CORTICAL EVOKED POTENTIALS ON MULTIPLE SCALP ELECTRODES IN TINNITUS PATIENTS SO BIOMEDICAL ENGINEERING-APPLICATIONS BASIS COMMUNICATIONS LA English DT Article DE Auditory cortical evoked potentials; Intensity dependence; Isoelectric topography; Current source density; Brain imaging ID FUNCTIONAL NEUROANATOMY; TARGET DETECTION; ACTIVATION; CORTEX; FMRI AB Tinnitus affects 10 - 15% of the population and tends to increase in frequency among older ages. The published reports have converged on that tinnitus is the sustained neuroplastic changes with aberrant activity residing in the auditory and nonauditory nervous systems that cause the sensation and problem of tinnitus. Clinically tinnitus remains as a subjective symptom and cannot be evaluated objectively. Our previous study has demonstrated the significantly different intensity dependence of auditory cortical evoked potential ( ACEP) amplitudes to pure-tone stimuli recorded at some midline scalp electrodes between normal controls and tinnitus patients. Although ACEP test has been well known for its excellent temporal resolution of milliseconds and the latency and amplitude of ACEPs give ample information about the auditory processing of tinnitus, these measurements at each electrode deliver insufficient information about the spatial correlation among different cortical locations. According to the neurophysiological model of tinnitus, temporal and spatial information are both necessary and complementary to study the underlying mechanisms of problem tinnitus. Thus the purpose of this study was to demonstrate the spatial presentations of ACEP N1-P2 of normal controls and tinnitus patients. In this work, a program has been developed to translate the ACEPs recorded at 30 scalp electrodes to a two-dimensional presentation of isoelectric topography and current source density. The differences of intensity dependence about N1-P2 noted with previous study are reviewed on the two spatial presentations and compared between control subjects and tinnitus patients, while the patterns of correlation are demonstrated and compared with those recorded by functional brain imaging techniques like PET and fMRI. C1 [Lee, Chung-Yi; Shih, Yen-Yu; Jaw, Fu-Shan] Natl Taiwan Univ, Coll Med, Inst Biomed Engn, Taipei 10764, Taiwan. [Lee, Chung-Yi; Shih, Yen-Yu; Jaw, Fu-Shan] Natl Taiwan Univ, Coll Engn, Taipei 10764, Taiwan. [Lee, Chung-Yi] Natl Taiwan Univ, Coll Med, Dept Otolaryngol, Taipei 10764, Taiwan. [Lee, Chung-Yi] Natl Taiwan Univ Hosp, Taipei, Taiwan. RP Jaw, FS (reprint author), Natl Taiwan Univ, Coll Med, Inst Biomed Engn, Taipei 10764, Taiwan. EM jaw@ntu.edu.tw RI Shih, Yen-Yu/A-2590-2010 FU National Science Council of Taiwan [NSC92-2218E002-015] FX This study was supported by a grant (NSC92-2218E002-015) from the National Science Council of Taiwan. 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Eng.-Appl. Basis Commun. PD OCT PY 2008 VL 20 IS 5 BP 297 EP 302 DI 10.4015/S101623720800091X PG 6 WC Computer Science, Interdisciplinary Applications; Engineering, Biomedical SC Computer Science; Engineering GA 376FB UT WOS:000261168300004 ER PT J AU Welch, D Dawes, PJD AF Welch, David Dawes, Patrick J. D. TI Personality and perception of tinnitus SO EAR AND HEARING LA English DT Article ID LIFE-COURSE; GENDER-DIFFERENCES; CHILDHOOD; SUFFERERS; QUESTIONNAIRE; DEPRESSION; DISORDERS; INVENTORY; ADULTHOOD; SEVERITY AB Objectives: Tinnitus has high prevalence and a wide range of etiologies and of impacts on sufferers. Our objective was to develop understanding of the role of personality in the perception of tinnitus in the general population. As a theoretical basis for this, we combined elements of a general model of signal detection with the ideas of ignition (development) and promotion (neural transmission) of tinnitus, and considered plausible roles for personality factors within this conceptual framework. Design: We interviewed a birth cohort of 970 people aged 32 yr sampled from the general population. On the basis of questioning, we divided them into three groups, those without tinnitus, those with occasional tinnitus (including those with transient tinnitus of very brief duration), and those who experienced tinnitus most of the time. We also established how annoying or distressing the tinnitus was, and assessed personality using the Multidimensional Personality Questionnaire. Results: Tinnitus was experienced rarely by 38.2% and half the time or more by 6.8% of those studied. Men and women did not differ in the amount of tinnitus reported, but women were more likely to find it annoying. People from lower socioeconomic backgrounds were more likely to report tinnitus. People with tinnitus were more socially withdrawn, reactive to stress, alienated, and less Self-Controlled. People who were more annoyed by tinnitus were more socially withdrawn, and men were more stress reactive and alienated. Conclusions: Our interpretation of the findings is that personality influences the persistence of tinnitus by influencing the tendency to be aware of it. Consideration of personality factors may improve the ability to tailor tinnitus therapies, and the concept of awareness may benefit treatment outcomes by showing tinnitus sufferers a means of internalizing the locus of control over their symptoms. C1 [Welch, David] Univ Otago, Dunedin Sch Med, Dept Prevent & Social Med, Dunedin Multidisciplinary Hlth & Dev Res Unit, Dunedin, New Zealand. [Dawes, Patrick J. D.] Univ Otago, ORL HNS Dunedin Sch Med, Dunedin, New Zealand. RP Welch, D (reprint author), Univ Otago, Dunedin Sch Med, Dept Prevent & Social Med, Dunedin Multidisciplinary Hlth & Dev Res Unit, POB 913, Dunedin, New Zealand. EM david.welch@dmhdru.otago.ac.nz FU Health Research Council of New Zealand; US NIMH [MH49414] FX The Dunedin Multidisciplinary Health and Development Research Unit was supported by the Health Research Council of New Zealand. Data collection was partially supported by US NIMH grant number MH49414. 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PD OCT PY 2008 VL 29 IS 5 BP 684 EP 692 DI 10.1097/AUD.0b013e318177d9ac PG 9 WC Audiology & Speech-Language Pathology; Otorhinolaryngology SC Audiology & Speech-Language Pathology; Otorhinolaryngology GA 350FS UT WOS:000259338700003 PM 18596645 ER PT J AU Argence, M Vassias, I Kerhuel, L Vidal, PP de Waele, C AF Argence, Meritxell Vassias, Isabelle Kerhuel, Lubin Vidal, Pierre-Paul de Waele, Catherine TI Stimulation by cochlear implant in unilaterally deaf rats reverses the decrease of inhibitory transmission in the inferior colliculus SO EUROPEAN JOURNAL OF NEUROSCIENCE LA English DT Article DE auditory implant; auditory nerve stimulation; deafness; GAD67; glycine receptors; postinjury plasticity ID AUDITORY BRAIN-STEM; GLUTAMIC-ACID DECARBOXYLASE; ELECTRICAL INTRACOCHLEAR STIMULATION; ADULT GUINEA-PIG; SUBUNIT MESSENGER-RNAS; IN-SITU HYBRIDIZATION; SPIRAL GANGLION; SYNAPTIC-TRANSMISSION; C-FOS; CONTAINING NEURONS AB In the last decade, numerous studies have investigated synaptic transmission changes in various auditory nuclei after unilateral cochlear injury. However, few data are available concerning the potential effect of electrical stimulation of the deafferented auditory nerve on the inhibitory neurotransmission in these nuclei. We report here for the first time the effect of chronic electrical stimulation of the deafferented auditory nerve on alpha 1 subunit of the glycinergic receptor (GlyR alpha 1) and glutamic acid decarboxylase (GAD)67 expression in the central nucleus of inferior colliculus (CIC). Adult rats were unilaterally cochleectomized by intracochlear neomycin sulphate injection. Fifteen days later, the ipsilateral auditory nerve was chronically stimulated either 4, 8 or 22 h daily, for 5 days using intracochlear bipolar electrodes. GlyR alpha 1 and GAD67 mRNA and protein were quantified in the CIC using in situ hybridization and immunohistofluorescence methods. Our data showed that as after surgical ablation, GlyR alpha 1 and GAD67 expression were strongly decreased in the contralateral CIC after unilateral chemical cochleectomy. Most importantly, these postlesional down-modulations were significantly reversed by chronic electrical stimulation of the deafferented auditory nerve. This recovery, however, did not persist for more than 5 days after the cessation of the deafferented auditory nerve electrical stimulation. Thus, downregulations of GlyR alpha 1 and GAD67 may be involved both in the increased excitability observed in the CIC after unilateral deafness and consequently in the tinnitus frequently observed in unilateral adult deaf patients. Electrical stimulation of the deafferented auditory nerve in patients may be a potential new approach for treating tinnitus with unilateral hearing loss. 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J. Neurosci. PD OCT PY 2008 VL 28 IS 8 BP 1589 EP 1602 DI 10.1111/j.1460-9568.2008.06454.x PG 14 WC Neurosciences SC Neurosciences & Neurology GA 360IF UT WOS:000260050500013 PM 18973578 ER PT J AU Linder, S Nowak, DA Rodiek, SO Lumenta, C Topka, H AF Linder, Stefan Nowak, Dennis A. Rodiek, Sven-Olaf Lumenta, Christianto Topka, Helge TI Secondary intracranial hypertension with acute intracranial pressure crisis in superficial siderosis SO JOURNAL OF CLINICAL NEUROSCIENCE LA English DT Article DE superficial siderosis; central nervous system; intracranial hypertension; intracranial pressure; chronic subarachnoid hemorrhage ID CENTRAL-NERVOUS-SYSTEM AB Superficial siderosis of the central nervous system is a very rare disease related to hemosiderin deposits in the brain, brainstem, cerebellum and spinal cord due to chronic subarachnoid hemorrhage. Chronic increased intracranial pressure develops in about one-third of affected cases. We report a patient with superficial siderosis and sudden intracranial pressure crisis. A 29-year-old man experienced a subacute episode of headache, tinnitus and blurred vision. Magnetic resonance imaging of the brain revealed hemosiderin deposits characteristic of superficial siderosis. Extensive diagnostic work-up excluded causative pathologies of bleeding. Lumbar puncture and continuous intra-ventricular cerebrospinal fluid (CSF) pressure monitoring revealed continuous CSF pressure increase. Implantation of a ventriculo-peritoneal shunt led to complete clinical recovery. Our case emphasizes that patients with superficial siderosis may present with sudden elevation of intracranial pressure due to chronic intracranial hypertension. In this situation permanent CSF drainage provides a useful therapeutic option. (C) 2007 Elsevier Ltd. All rights reserved. C1 [Linder, Stefan; Topka, Helge] Tech Univ Munich, Acad Hosp Bogenhausen, Dept Neurol & Clin Neurophysiol, D-81925 Munich, Germany. [Nowak, Dennis A.] Univ Cologne, Dept Neurol, Cologne, Germany. [Rodiek, Sven-Olaf] Tech Univ Munich, Acad Hosp Bogenhausen, Dept Radiol, D-81925 Munich, Germany. [Lumenta, Christianto] Tech Univ Munich, Acad Hosp Bogenhausen, Dept Neurosurg, D-81925 Munich, Germany. RP Linder, S (reprint author), Tech Univ Munich, Acad Hosp Bogenhausen, Dept Neurol & Clin Neurophysiol, Englschalkingerstr 77, D-81925 Munich, Germany. EM steve_linder@gmx.de CR FEARNLEY JM, 1995, BRAIN, V118, P1051, DOI 10.1093/brain/118.4.1051 Hamill RC, 1908, J NERV MENT DIS, V35, P594, DOI [10.1097/00005053-190809000-00027, DOI 10.1097/00005053-190809000-00027] KOEPPEN AH, 1993, ANN NEUROL, V34, P646, DOI 10.1002/ana.410340505 Kumar N, 2006, NEUROLOGY, V66, P1144, DOI 10.1212/01.wnl.0000208510.76323.5b Longridge NS, 1996, J OTOLARYNGOL, V25, P41 TOMLINSON BE, 1964, J NEUROL NEUROSUR PS, V27, P332, DOI 10.1136/jnnp.27.4.332 NR 6 TC 2 Z9 3 PU CHURCHILL LIVINGSTONE PI EDINBURGH PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE, LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND SN 0967-5868 J9 J CLIN NEUROSCI JI J. Clin. Neurosci. PD OCT PY 2008 VL 15 IS 10 BP 1168 EP 1170 DI 10.1016/j.jocn.2007.06.011 PG 3 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA 350AM UT WOS:000259324800026 PM 18653343 ER PT J AU Trotrer, MI Donaldson, I AF Trotrer, M. I. Donaldson, I. TI Hearing aids and tinnitus therapy: a 25-year experience SO JOURNAL OF LARYNGOLOGY AND OTOLOGY LA English DT Article DE Tinnitus; Hearing Loss; Hearing Aids; Patient; Digital ID PREVALENCE; ADULTS AB Objectives: (1) To assess the subjective tinnitus perception of patients with audiologically proven heating loss presenting to a tinnitus clinic, both before and after hearing aid provision; (2) to investigate subjective tinnitus perception in patients with unilateral and bilateral hearing loss; and (3) to assess the impact on tinnitus perception, if any, of a digital hearing aid programme in patients provided with hearing aids. Design: Prospective data collection for patients attending a tinnitus clinic over a 25-year period (1980-2004). Setting: University teaching hospital otolaryngology department. Participants: A total of 2153 consecutive patients attending a consultant-delivered specialist tinnitus clinic. Main outcomes measures: A visual analogue scale was used to assess the degree of tinnitus perception improvement, if any, comparing before versus after unilateral or bilateral aiding (in those with audiometrically proven hearing loss). A further assessment compared the effect of digital hearing aid programme introduction on symptomatic tinnitus perception in patients provided with unilateral or bilateral aids. Results: A total of 1440 patients were given hearing aids (826 unilateral and 614 bilateral). There was little difference in tinnitus perception, comparing overall aiding results in unilaterally or bilaterally aided patients. Overall, 554 (67 per cent) of unilaterally aided patients and 424 (69 per cent) of bilaterally aided patients reported some improvement in their tinnitus perception following aiding. There was a statistically significant improvement in tinnitus perception, comparing analogue aids with digital hearing aids, following introduction of a digital hearing aid programme in 2000, in both unilaterally (p < 0.001) and bilaterally (p < 0.001) aided patients. Conclusions: Provision of hearing aids in patients with audiometrically demonstrable hearing loss can play a very important part in tinnitus control. The additional improvement in tinnitus control observed following introduction of programmable digital aids had a summative effect in the management of these patients. C1 [Trotrer, M. I.; Donaldson, I.] Univ Hosp Birmingham, ENT Dept, Birmingham, W Midlands, England. RP Trotrer, MI (reprint author), Univ Hosp Birmingham, ENT Dept, Birmingham, W Midlands, England. EM Matthew.Trotter@eyeandear.org.au CR AXELSSON A, 1989, British Journal of Audiology, V23, P53, DOI 10.3109/03005368909077819 Coles R R, 1984, J Laryngol Otol Suppl, V9, P7 DAVIS AC, 1989, INT J EPIDEMIOL, V18, P911, DOI 10.1093/ije/18.4.911 Dobie R, 2004, TINNITUS THEORY MANA, P1 Folmer RL, 2006, OTOLARYNG HEAD NECK, V134, P132, DOI 10.1016/j.otohns.2005.09.030 HAZELL JWP, 1985, J ROY SOC MED, V78, P56 HELLER MF, 1953, ANN OTO RHINOL LARYN, V62, P73 Jastreboff PJ, 1996, AM J OTOL, V17, P236 Klockhoff I, 1967, Acta Otolaryngol, V63, P347, DOI 10.3109/00016486709128769 McCombe A, 2001, CLIN OTOLARYNGOL, V26, P388, DOI 10.1046/j.1365-2273.2001.00490.x Newman CW, 1996, ARCH OTOLARYNGOL, V122, P143 Newman C W, 1998, J Am Acad Audiol, V9, P153 Nondahl David M, 2002, J Am Acad Audiol, V13, P323 Sahley TL, 2001, HEARING RES, V152, P43, DOI 10.1016/S0378-5955(00)00235-5 Sindhusake D, 2003, INT J AUDIOL, V42, P289, DOI 10.3109/14992020309078348 NR 15 TC 26 Z9 27 PU CAMBRIDGE UNIV PRESS PI CAMBRIDGE PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND SN 0022-2151 J9 J LARYNGOL OTOL JI J. Laryngol. Otol. PD OCT PY 2008 VL 122 IS 10 BP 1052 EP 1056 DI 10.1017/S002221510800203X PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA 364SD UT WOS:000260354700007 PM 18353195 ER PT J AU Choudhury, N Kumar, G Krishnan, M Gatland, DJ AF Choudhury, N. Kumar, G. Krishnan, M. Gatland, D. J. TI Atypical incus necrosis: a case report and literature review SO JOURNAL OF LARYNGOLOGY AND OTOLOGY LA English DT Article DE Incus; Conductive Deafness; Abnormalities AB Objective: We report an atypical case of ossicular necrosis affecting the incus, in the absence of any history of chronic serous otitis media. We also discuss the current theories of incus necrosis. Case report: A male patient presented with a history of right unilateral hearing loss and tinnitus. Audiometry confirmed right conductive deafness; tympanometry was normal bilaterally. He underwent a right exploratory tympanotomy, which revealed atypical erosion of the proximal long process of the incus. Middle-ear examination was otherwise normal, with a mobile stapes footplate. The redundant long process of the incus was excised and a partial ossicular replacement prosthesis was inserted, resulting in improved hearing. Conclusion: Ossicular pathologies most commonly affect the incus. The commonest defect is an absent lenticular and distal long process of the incus, which is most commonly associated with chronic otitis media. This is the first reported case of ossicular necrosis, particularly of the proximal long process of the incus, in the absence of chronic middle-ear pathology. C1 [Choudhury, N.; Kumar, G.; Krishnan, M.; Gatland, D. J.] Southend Univ Hosp Fdn Trust, Dept Otolaryngol, Southend On Sea, England. RP Choudhury, N (reprint author), 47 Priory Mews,Stn Ave, Prittlewell SS2 5EP, Southend, England. EM Natashamasood1@aol.com CR Alberti PW, 1965, J LARYNGOL OTOL, V79, P966 Banerjee AS, 2005, J LARYNGOL OTOL, V119, P733 LANNIGAN FJ, 1993, CLIN OTOLARYNGOL, V18, P387, DOI 10.1111/j.1365-2273.1993.tb00597.x LANNIGAN FJ, 1993, CLIN OTOLARYNGOL, V18, P155 MASHARANI U, 2004, BASIC CLIN ENDOCRINO, P658 NASRALLAH R, 2003, AM J PHYSIOL-RENAL, V285, P1068 NOMURA Y, 1988, LARYNGOSCOPE, V98, P390 TUZ M, 2006, J LARYNGOL OTOL, V120, P1 WATSON C, 1992, J LARYNGOL OTOL, V106, P252, DOI 10.1017/S002221510011919X NR 9 TC 2 Z9 2 PU CAMBRIDGE UNIV PRESS PI CAMBRIDGE PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND SN 0022-2151 J9 J LARYNGOL OTOL JI J. Laryngol. Otol. PD OCT PY 2008 VL 122 IS 10 BP 1124 EP 1126 DI 10.1017/S0022215107000953 PG 3 WC Otorhinolaryngology SC Otorhinolaryngology GA 364SD UT WOS:000260354700023 PM 17967207 ER PT J AU Crane, BT Minor, LB Carey, JP AF Crane, Benjamin T. Minor, Lloyd B. Carey, John P. TI Superior Canal Dehiscence Plugging Reduces Dizziness Handicap SO LARYNGOSCOPE LA English DT Article DE Superior canal dehiscence; dizziness handicap inventory; human quality of life; VEMP; CT; DHI; SCDS ID PAROXYSMAL POSITIONAL VERTIGO; VESTIBULAR REHABILITATION; MENIERES-DISEASE; OUTCOMES; MANAGEMENT; INVENTORY; SURGERY AB Objectives/Hypothesis,: To compare dizziness handicap inventory (DHI) scores before and after surgery for plugging of superior canal dehiscence (SCD). The size of the dehiscence as measured during surgery, subject age, vestibular-evoked myogenic potentials threshold, and degree of conductive hearing loss (CBL) were also considered. Study Design: Retrospective. Methods: Nineteen adults with SCD who underwent surgery to plug the SCD via middle fossa approach were studied. Pre- and postoperative DHI scores were compared, and correlations between DHI scores and other clinical measures were assessed. Results: Average preoperative DHI score was 44 +/- 24 (mean +/- SD). Postoperative DHI score was significantly lower at 18 +/- 15 (P <.01). Only two subjects had a higher DHI score after surgery. Subjects who had a preoperative DHI score below 30 did not have any significant change in their DHI score after surgery, whereas those with a preoperative DHI score >= 30 had an improvement by an average of 39 +/- 16 after surgery. There were no correlations between either preoperative DHI score or the change in DHI score after surgery and HL, age, vestibular-evoked myogenic potentials threshold, or dehiscence size. Conclusions: DHI scores significantly decreased after SCD plugging. Subjects who had the largest decrease in DHI scores were those with high preoperative DHI scores. Subjects who chose to undergo SCD plugging because of nonvestibular symptoms such as conductive HL, tinnitus, or autophony generally had lower preoperative DHI scores and did not experience large improvements in DHI scores. The SCD plugging procedure offers an improvement in DHI score that is comparable with that of other procedures for peripheral vestibular dysfunction. C1 [Crane, Benjamin T.; Minor, Lloyd B.; Carey, John P.] Johns Hopkins Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, Johns Hopkins Outpatient Ctr, Baltimore, MD 21287 USA. RP Carey, JP (reprint author), Johns Hopkins Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, Johns Hopkins Outpatient Ctr, 6th Floor,601 N Caroline St, Baltimore, MD 21287 USA. EM jcarey@jhmi.edu CR Badke MB, 2002, OTOL NEUROTOL, V23, P504, DOI 10.1097/00129492-200207000-00019 Brantberg K, 1999, ACTA OTO-LARYNGOL, V119, P633 Brantberg K, 2001, ACTA OTO-LARYNGOL, V121, P68 Brown KE, 2001, LARYNGOSCOPE, V111, P1812, DOI 10.1097/00005537-200110000-00027 Carey JP, 2007, OTOL NEUROTOL, V28, P356, DOI 10.1097/01.mao.0000253284.40995.d8 Cowand JL, 1998, OTOLARYNG HEAD NECK, V118, P49, DOI 10.1016/S0194-5998(98)70374-2 Cremer PD, 2000, NEUROLOGY, V55, P1833 Gill-Body KM, 2000, PHYS THER, V80, P748 Gottshall KR, 2005, OTOLARYNG HEAD NECK, V133, P326, DOI 10.1016/j.otohns.2005.06.001 Hillman TA, 2006, OTOLARYNG HEAD NECK, V134, P431, DOI 10.1016/j.otohns.2005.10.033 Humphriss RL, 2003, OTOL NEUROTOL, V24, P661, DOI 10.1097/00129492-200307000-00021 Limb CJ, 2006, OTOL NEUROTOL, V27, P969, DOI 10.1097/01.mao.0000235376.70492.8e Lopez-Escamez JA, 2003, OTOL NEUROTOL, V24, P637, DOI 10.1097/00129492-200307000-00018 Mikulec AA, 2005, LARYNGOSCOPE, V115, P501, DOI 10.1097/01.mlg.0000157844.48036.e7 Minor LB, 2000, AM J OTOL, V21, P9 Minor LB, 1998, ARCH OTOLARYNGOL, V124, P249 Minor LB, 2005, LARYNGOSCOPE, V115, P1717, DOI 10.1097/01.mlg.000178324.55729.b7 JACOBSON GP, 1990, ARCH OTOLARYNGOL, V116, P424 O'Reilly RC, 2000, LARYNGOSCOPE, V110, P1385, DOI 10.1097/00005537-200008000-00031 Perez N, 2003, LARYNGOSCOPE, V113, P456, DOI 10.1097/00005537-200303000-00013 Pletcher SD, 2005, ORL J OTO-RHINO-LARY, V67, P192, DOI 10.1159/000086663 Shaia WT, 2006, OTOLARYNG HEAD NECK, V134, P424, DOI 10.1016/j.otohns.2005.10.035 Tufarelli D, 2007, OTOL NEUROTOL, V28, P814, DOI 10.1097/MAO.0b013e31811f40ad Welgampola MS, 2008, NEUROLOGY, V70, P464, DOI 10.1212/01.wnl.0000299084.76250.4a Wrisley DM, 2002, OTOL NEUROTOL, V23, P483, DOI 10.1097/00129492-200207000-00016 Zhou GW, 2007, OTOL NEUROTOL, V28, P920 NR 26 TC 24 Z9 24 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0023-852X J9 LARYNGOSCOPE JI Laryngoscope PD OCT PY 2008 VL 118 IS 10 BP 1809 EP 1813 DI 10.1097/MLG.0b013e31817f18fa PG 5 WC Medicine, Research & Experimental; Otorhinolaryngology SC Research & Experimental Medicine; Otorhinolaryngology GA 368ZR UT WOS:000260662800020 PM 18622314 ER PT J AU Park, JH Kim, H Han, HJ AF Park, Jong-Ho Kim, Hyeyun Han, Hyun-Jeong TI Recurrent audiovestibular disturbance initially mimicking Meniere's disease in a patient with anterior inferior cerebellar infarction SO NEUROLOGICAL SCIENCES LA English DT Article DE Recurrent deafness; Vertigo; Anterior inferior cerebellar artery infarction; Elderly; Risk factor ID ARTERY INFARCTION; VERTIGO AB An anterior inferior cerebellar artery (AICA) stroke is characterized by vertigo, tinnitus, and deafness in addition to facial weakness, hemiataxia, and hypalgesia. Sometimes, it can present as sudden deafness with vertigo, without brainstem or cerebellar signs. We report a 55-year-old woman with hypertension and diabetes, showing recurrent audiovestibular disturbance before a typical pattern of AICA infarction, which was initially diagnosed as Meniere's disease. In elderly patients with recurrent hearing loss and vertigo lasting several minutes, lack classic brainstem or cerebellar signs, if they have vascular risk factors, physicians may also consider the potential symptom of AICA infarction. C1 [Park, Jong-Ho; Kim, Hyeyun; Han, Hyun-Jeong] Kwandong Univ, Coll Med, Myongji Hosp, Dept Neurol, Goyang Si 412270, Kyunggi Do, South Korea. RP Park, JH (reprint author), Kwandong Univ, Coll Med, Myongji Hosp, Dept Neurol, 697-24 Hwajeong Dong, Goyang Si 412270, Kyunggi Do, South Korea. EM neurocraft@kd.ac.kr CR Ballester M, 2002, OTOL NEUROTOL, V23, P73, DOI 10.1097/00129492-200201000-00017 Baloh RW, 1998, DIZZINESS HEARING LO BOGOUSSLAVSKY J, 2001, STROKE SYNDROMES, P546 GRAD A, 1989, ARCH NEUROL-CHICAGO, V46, P281 LEE H, 2004, J NEUROL SCI, V106, P105 Lee H, 2002, STROKE, V33, P2807, DOI 10.1161/01.STR.0000038692.17290.24 Lee H, 2003, J NEUROL NEUROSUR PS, V74, P1644, DOI 10.1136/jnnp.74.12.1644 LEVINE RA, 1993, ANN OTO RHINOL LARYN, V102, P127 OAS JG, 1992, NEUROLOGY, V42, P2274 PAPARELLA MM, 1985, ACTA OTO-LARYNGOL, V99, P445, DOI 10.3109/00016488509108936 PERLMAN H B, 1959, Laryngoscope, V69, P591 Son EJ, 2007, LARYNGOSCOPE, V117, P556, DOI 10.1097/MLG.0b013e3180303ed0 WATANABE Y, 1995, ACTA OTO-LARYNGOL, P206 WLADISLAVOSKYWASERMAN P, 1984, LARYNGOSCOPE, V94, P1098 NR 14 TC 0 Z9 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1590-1874 J9 NEUROL SCI JI Neurol. Sci. PD OCT PY 2008 VL 29 IS 5 BP 359 EP 362 DI 10.1007/s10072-008-0996-0 PG 4 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA 363UW UT WOS:000260293400011 PM 18941941 ER PT J AU Sismanis, A Girevendoulis, A AF Sismanis, Aristides Girevendoulis, Alexander TI Pulsatile Tinnitus Associated With Internal Carotid Artery Morphologic Abnormalities SO OTOLOGY & NEUROTOLOGY LA English DT Article DE Coiling; Computed tomography angiography; Pulsatile tinnitus; Tortuosity ID OBJECTIVE TINNITUS; KINKING; COILING; HYPERTENSION; TORTUOSITY; DIAGNOSIS; DEVICE AB Objectives: Internal carotid artery morphologic abnormalities mainly consist of tortuosities and coilings and can present with pulsatile tinnitus (PT). The purpose of this presentation is to report 3 representative cases and propose clinical and radiologic diagnostic criteria. Patients: Three patients presenting with PT. Intervention: Clinical evaluation including auscultation of the ear canal and head and neck. All patients underwent computed tomography angiography of the head and neck. Main Outcome Measures: Clinical evaluation, computed tomography angiography of the head and neck. Results: Head bruit or objective tinnitus were detected in 2 patients. Symptoms of cerebral ischemia were absent. All patients were found to have tortuosities of the internal carotid arteries below the cranium base. One patient, in addition to tortuosity, had coiling as well. Conclusion: Morphologic abnormalities of the internal carotid artery may be associated with PT. Proper clinical evaluation coupled with computed tomography angiography of the head and neck can differentiate these abnormalities, from other more serious vascular etiologies. Symptoms of cerebral ischemia warrant consultation with a vascular surgeon. C1 [Sismanis, Aristides] Virginia Commonwealth Univ, Med Ctr, Dept Otolaryngol Head & Neck Surg, Richmond, VA USA. [Girevendoulis, Alexander] Virginia Commonwealth Univ, Med Ctr, Dept Radiol, Richmond, VA USA. RP Sismanis, A (reprint author), AD Williams Bldg,Suite 402,1201 E Marshall St,POB, Richmond, VA 23298 USA. EM asismanis@aol.com CR Aleksic M, 2004, J CARDIOVASC SURG, V45, P43 Buskens E, 2004, RADIOLOGY, V233, P101, DOI 10.1148/radiol.2331030863 CARY FH, 1961, NEW ENGL J MED, V264, P869, DOI 10.1056/NEJM196104272641709 COCHRAN JH, 1979, ANN OTO RHINOL LARYN, V88, P297 De Monti M, 2003, Minerva Cardioangiol, V51, P373 Illuminati G, 2008, SURGERY, V143, P134, DOI 10.1016/j.surg.2007.07.029 Karamessini MT, 2004, EUR J RADIOL, V49, P212, DOI 10.1016/S0720-048X(03)00173-6 Krishnan A, 2006, AM J NEURORADIOL, V27, P1635 La Barbera G, 2006, SURG RADIOL ANAT, V28, P573, DOI 10.1007/s00276-006-0149-1 Macchi C, 1997, J CARDIOVASC SURG, V38, P629 Pancera P, 2000, J INTERN MED, V248, P7, DOI 10.1046/j.1365-2796.2000.00611.x SISMANIS A, 1989, OTOLARYNG HEAD NECK, V100, P644 SISMANIS A, 1987, LARYNGOSCOPE, V97, P1, DOI 10.1288/00005537-198708001-00001 SISMANIS A, 1994, OTOLARYNG HEAD NECK, V110, P459 Togay-Isikay C, 2005, ACTA NEUROL BELG, V105, P68 NR 15 TC 6 Z9 6 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1531-7129 J9 OTOL NEUROTOL JI Otol. Neurotol. PD OCT PY 2008 VL 29 IS 7 BP 1032 EP 1036 DI 10.1097/MAO.0b013e3181865913 PG 5 WC Clinical Neurology; Otorhinolaryngology SC Neurosciences & Neurology; Otorhinolaryngology GA 365ZQ UT WOS:000260449100025 PM 18818546 ER PT J AU Rasheed, A Saeed, S AF Rasheed, Abdul Saeed, Shahzad TI IN VIVO EFFICACY AND SAFETY OF QUININE-DOXYCYCLINE COMBINATION IN ACUTE PLASMODIUM FALCIPARUM MALARIA SO PAKISTAN JOURNAL OF MEDICAL SCIENCES LA English DT Article DE Quinine doxycyline combination; Malaria; Plasmodium falciparum; Mixed infection AB Objective: To find out the in vivo efficacy and adverse effects of quinine doxycycline combination in malaria caused by Plasmodium (R) falciparum. Methodology: It is a prospective, observational study conducted at Department of Medicine, Combined Military Hospital, Quetta, Balochistan, Pakistan, from September 2006 to December 2006. Three hundred thirty seven subjects with positive P.falciparum rings on malaria slide fulfilled the selection criteria and were included in the study. Mean, minimum and maximum values along with standard deviation of age, malarial parasite index fever clearance time and parasite clearance time were calculated. Frequencies of various adverse events and deaths observed during this study were also calculated. Results: Of 337 subjects, 256 had P.falciparum while 81 had mixed infection involving both P.falciparum and P.vivax. Mean fever clearance times in P.falciparum infected subjects and mixed infection were 46.3 hours and 44.16 hours respectively. The mean parasite clearance times in P.falciparum infected subjects and mixed infection were 70.32 hours and 68 hours respectively. About 3.3% of the subjects developed mild to moderate side effects including tinnitus, prolongation of QT interval and vomiting. Mortality rate observed in this study was about 0.6%. Conclusion: Quinine doxycycline combination therapy may be used safety and effectively in the management of P.falciparum malaria. C1 [Rasheed, Abdul; Saeed, Shahzad] Combined Mil Hosp, Dept Med, Quetta, Pakistan. RP Rasheed, A (reprint author), Flat 8,Rukayya Manzil,339 Bohri Bazar Saddar, Hyderabad, Andhra Pradesh, India. 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Biplab, 2001, Journal of Communicable Diseases, V33, P83 *WHO, 1998, US ART ITS DER ANT *WHO UNICEF, 2005, HTMMAL20051102 WHO U World Health Organization (WHO), 2001, ANT DRUG COMB THER NR 18 TC 1 Z9 1 PU PROFESSIONAL MEDICAL PUBLICATIONS PI SADDAR PA PANORAMA CENTRE, RM 522, 5TH FLOOR, BLDG 2, RAJA GHAZANFAR ALI RD, PO BOX 8766, SADDAR, KARACHI 00000, PAKISTAN SN 1682-024X J9 PAK J MED SCI JI Pak. J. Med. Sci. PD OCT-DEC PY 2008 VL 24 IS 5 BP 684 EP 688 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA 382UG UT WOS:000261630300009 ER PT J AU Oldenburg, J Fossa, SD Ikdahl, T AF Oldenburg, Jan Fossa, Sophie D. Ikdahl, Tone TI Genetic variants associated with cisplatin-induced ototoxicity SO PHARMACOGENOMICS LA English DT Review DE audiometric; chemotherapy; cisplatin; glutathione; GST; GSTM1; GSTP1; hearing impairment; hearing loss; ototoxicity; pharmacogenetics; polymorphism; tinnitus ID TESTICULAR CANCER SURVIVORS; S-TRANSFERASE P1; GERM-CELL TUMORS; HIGH-FREQUENCY AUDIOMETRY; HEARING-LOSS; INDUCED CYTOTOXICITY; INDIVIDUAL SENSITIVITY; OTOACOUSTIC EMISSIONS; TEMPORAL BONE; RISK-FACTORS AB Cisplatin induces ototoxicity with a huge interindividual variation, which is at least partly based on genetic differences between the affected individuals. Identification of genetic variants that could predict the severity of ototoxicity is an important step towards a more individualized cisplatin treatment. Nevertheless, so far, only a few studies have assessed this issue. This review will address the prevalence of cisplatin-induced ototoxicity, its pathophysiology, quantification and associations with genetic variants. The recent progress in both phenotyping and genotyping is discussed. C1 [Oldenburg, Jan; Fossa, Sophie D.] Univ Oslo, Rikshosp, Norwegian Radium Hosp, Dept Clin Canc Res, N-0310 Oslo, Norway. [Oldenburg, Jan; Fossa, Sophie D.] Univ Oslo, Norwegian Radium Hosp, Fac Div, N-0316 Oslo, Norway. [Ikdahl, Tone] Ullevaal Univ Hosp, Ulleval Canc Ctr, Oslo, Norway. RP Oldenburg, J (reprint author), Univ Oslo, Rikshosp, Norwegian Radium Hosp, Dept Clin Canc Res, N-0310 Oslo, Norway. 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Panda, Naresh Khandelwal, Gaurav Lal, Vivek Mann, Sherbaj S. TI Migraine and audiovestibular dysfunction: is there a correlation? SO AMERICAN JOURNAL OF OTOLARYNGOLOGY LA English DT Article ID HEARING-LOSS; EPISODIC VERTIGO; RESPONSES AB Purpose: To study the audiovestibular functions in cases of migraine with or without vertigo. Materials and methods: This was a prospective study involving 50 cases of migraine who were divided into 2 groups: patients with vertigo and those without. All patients underwent a detailed otological and neurootological examination followed by full audiological and vestibular investigation including pure tone audiometry, speech reception threshold, speech discrimination score, tone decay, short increment sensitivity index, auditory brainstem-evoked responses, and electronystagmography (ENG). Results: Thirty-eight (76%) of 50 patients had vertigo on presentation, of which rotatory nonpositional vertigo (22/38) was the most common. Phonophobia was the most common auditory symptom (35/50, 70%) followed by tinnitus (25/50, 50%). Only 17 patients (34%) reported hearing loss, of whom only 7 had documented hearing loss on pure tone audiometry. However, the auditory brainstem-evoked responses of all these patients showed some abnonrmalities in the form of prolonged absolute latency or prolonged interwave peak latencies or both. Electronystagmography revealed canal paresis in 13 patients (26%), although there was no statistical difference between patients with or without vertigo on various electronystagmographic parameters. Conclusion: Auditory brainstem-evoked response abnormalities may be the earliest indicator of impending auditory involvement in migraine. (C) 2008 Published by Elsevier Inc. C1 [Dash, Anil K.; Panda, Naresh; Khandelwal, Gaurav; Lal, Vivek; Mann, Sherbaj S.] Postgrad Inst Med Educ & Res, Dept Otolaryngol, Chandigarh 160012, India. RP Panda, N (reprint author), Postgrad Inst Med Educ & Res, Dept Otolaryngol, Chandigarh 160012, India. 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J. Otolaryngol. PD SEP-OCT PY 2008 VL 29 IS 5 BP 295 EP 299 DI 10.1016/j.amjoto.2007.09.004 PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA 347AW UT WOS:000259112100001 PM 18722884 ER PT J AU de Heyning, PV Vermeire, K Diebl, M Nopp, P Anderson, I De Ridder, D AF de Heyning, Paul Van Vermeire, Katrien Diebl, Martina Nopp, Peter Anderson, Ilona De Ridder, Dirk TI Incapacitating unilateral tinnitus in single-sided deafness treated by cochlear implantation SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE cochlear implantation; single-sided deafness; tinnitus ID TRANSCRANIAL MAGNETIC STIMULATION; ENRICHED ACOUSTIC ENVIRONMENT; NOISE TRAUMA; AUDITORY-CORTEX; SUPPRESSION; REORGANIZATION; NEUROSTIMULATION AB Objectives: Tinnitus is a well-known, difficult-to-treat symptom of hearing loss. Users of cochlear implants (CIs) have reported a reduction in tinnitus following implantation for bilateral severe-to-profound deafness. This study assessed the effect of electrical stimulation via a CI on tinnitus in subjects with unilateral deafness and ipsilateral tinnitus who underwent implantation in an attempt to treat tinnitus with the CI. Methods: Twenty-one subjects who complained of severe intractable tinnitus that was unresponsive to treatment received a CI. Tinnitus loudness was measured with a Visual Analog Scale; loudness percepts were recorded with the device activated and deactivated. Tinnitus distress was measured with the Tinnitus Questionnaire before and after implantation. Results: Electrical stimulation via a CI resulted in a significant reduction in tinnitus loudness (mean +/- SD; 1 year after implantation, 2.4 +/- 1.8; 2 years after implantation, 2.5 +/- 1.9; before implantation, 8.5 +/- 1.3). With the device deactivated, tinnitus loudness was still reduced to between 6.1 and 7.0 over 24 months. The Tinnitus Questionnaire revealed a significant positive effect of CI stimulation. Conclusions: Unilateral tinnitus resulting from single-sided deafness can be treated with electrical stimulation via a CI. The outcomes of this pilot study demonstrate a new method for treatment of tinnitus in select subjects, perhaps an important new indication for cochlear implantation. C1 [de Heyning, Paul Van; Vermeire, Katrien] Univ Antwerp, Dept Otorhinolaryngol Head & Neck Surg, Univ Antwerp Hosp, B-2650 Edegem, Belgium. [De Ridder, Dirk] Univ Antwerp, Dept Neurosurg, Univ Antwerp Hosp, B-2650 Edegem, Belgium. [Diebl, Martina; Nopp, Peter; Anderson, Ilona] MED EL GmbH, Innsbruck, Austria. RP de Heyning, PV (reprint author), Univ Antwerp, Dept Otorhinolaryngol Head & Neck Surg, Univ Antwerp Hosp, Wilrijkstr 10, B-2650 Edegem, Belgium. 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Otol. Rhinol. Laryngol. PD SEP PY 2008 VL 117 IS 9 BP 645 EP 652 PN 1 PG 8 WC Otorhinolaryngology SC Otorhinolaryngology GA 352MR UT WOS:000259501800003 ER PT J AU Weise, C Heinecke, K Rief, W AF Weise, Cornelia Heinecke, Kristin Rief, Winfried TI Stability of physiological variables in chronic tinnitus sufferers SO APPLIED PSYCHOPHYSIOLOGY AND BIOFEEDBACK LA English DT Article DE stability; psychophysiological parameters; surface-EMG; tinnitus ID TEMPORAL STABILITY; PSYCHOPHYSIOLOGICAL ASSESSMENT; TEST-RETEST; RELIABILITY; BIOFEEDBACK; STRESS; REACTIVITY; ONSET AB The etiological tinnitus models propose that suffering can be caused and aggravated by heightened physiological arousal. Therefore psychophysiological treatments are applied. Stability of the measured parameters is essential for the use of biofeedback as well as to permit the attribution of changes to the administered treatment. The aim of our study was to investigate the 3-month reproducibility of psychophysiological parameters in 60 tinnitus patients. Using a repeated-measures design, the activity of these parameters was assessed twice during various stress and relaxation trials. The results showed that the measurements of frontalis, masseter and trapezius muscles were stable, while for the sternocleidomastoid, the skin conductance level (SCL) and the skin temperature retest-stability could not be evidenced. For all parameters, test-retest stability was weak for the relative scores. In conclusion, our study has important implications for applied psychophysiology research: (1) the measurement of EMG assessed in a clinical sample is stable over a 3-month interval; (2) in contrast, the measurements of SCL and skin temperature as well as all relative scores are less stable; and (3) the stability of EMG-parameters in our sample gives first hints that physiological changes can be attributed to an administered biofeedback treatment but further research is required. C1 [Weise, Cornelia; Heinecke, Kristin; Rief, Winfried] Univ Marburg, Dept Clin Psychol & Psychotherapy, Fac Psychol, D-35032 Marburg, Germany. RP Weise, C (reprint author), Univ Marburg, Dept Clin Psychol & Psychotherapy, Fac Psychol, Gutenbergstr 18, D-35032 Marburg, Germany. 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Psychophysiol. Biofeedback PD SEP PY 2008 VL 33 IS 3 BP 149 EP 159 DI 10.1007/s10484-008-9058-x PG 11 WC Psychology, Clinical SC Psychology GA 351GC UT WOS:000259411600003 PM 18600443 ER PT J AU Abiko, M Ikawa, F Ohbayashi, N Mitsuhara, T Ichinose, N Inagawa, T AF Abiko, M. Ikawa, F. Ohbayashi, N. Mitsuhara, T. Ichinose, N. Inagawa, T. TI Endovascular Treatment for Dural Arteriovenous Fistula of the Anterior Condylar Confluence Involving the Anterior Condylar Vein A Report of Two Cases SO INTERVENTIONAL NEURORADIOLOGY LA English DT Article DE dural arteriovenons fistula; anterior condylar confluence; anterior condylar vein; hypoglossal canal ID VENOUS DRAINAGE; FORAMEN; SINUS AB Anterior condylar confluence (ACC) dural arteriovenous fistula (AVF) is a rare anomaly We describe two cases of ACC dural AVF involving the anterior condylar vein that were successfully treated with selective transvenous coil embolization. The first patient presented with headache and right pulse-synchronous tinnitus, and demonstrated abnormal flow medial to the jugular bulb within the right hypoglossal canal on source image of magnetic resonance angiography (MRA). Arterioangiography disclosed a dural AVF in this area, supplied mainly by the meningeal branches of the bilateral ascending pharyngeal artery. We diagnosed ACC dural AVF involving the anterior condylar vein and transvenous embolization was successfully performed. The second patient presented with right pulse-synchronous tinnitus. Views of source image of MRA and arterioangiography were similar to the first case and, again, transvenous embolization was successfully performed. ACC dural AVF is a rare condition and knowledge of the anatomy of the venous system around the craniocervical junction is required for successful treatment. C1 [Abiko, M.; Ikawa, F.; Ohbayashi, N.; Mitsuhara, T.; Ichinose, N.; Inagawa, T.] Shimane Prefectural Cent Hosp, Dept Neurosurg, Izumo, Shimane 6938555, Japan. RP Abiko, M (reprint author), Shimane Prefectural Cent Hosp, Dept Neurosurg, Himebara 4-1-1, Izumo, Shimane 6938555, Japan. 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PD SEP PY 2008 VL 14 IS 3 BP 313 EP 317 PG 5 WC Clinical Neurology; Radiology, Nuclear Medicine & Medical Imaging SC Neurosciences & Neurology; Radiology, Nuclear Medicine & Medical Imaging GA 407NI UT WOS:000263371200011 PM 20557729 ER PT J AU Tan, TY Lin, YY Schminke, U Chen, TY AF Tan, Teng-Yeow Lin, Yun-Yu Schminke, Ulf Chen, Ting-Yao TI Pulsatile tinnitus in a case of traumatic temporal extradural arteriovenous fistula: Carotid duplex sonography findings before and after embolization SO JOURNAL OF CLINICAL ULTRASOUND LA English DT Article DE carotid arteries; duplex Doppler sonography; arteriovenous fistula; resistance index ID VENOUS DRAINAGE AB Carotid duplex sonography (CDS) is regarded as a screening tool for lateral dural arteriovenous fistulae (AVF). However, data on evaluating long-term effects of endovascular treatment are limited. We report the CDS findings in the feeding arteries of a traumatic temporal extradural AVF before and after transarterial embolization. Volume flow of the left common carotid artery was greater than the right (433 ml/minute versus 294 ml/minute right) and the resistance index of the left external carotid artery was lower than the right (0.69 left versus 0.84 right). Both parameters returned to normal 4 months after embolization, thus confirming successful endovascular treatment. (C) 2008 Wiley Periodicals, Inc. C1 [Tan, Teng-Yeow; Lin, Yun-Yu; Chen, Ting-Yao] Chang Gung Univ, Chang Gung Mem Hosp, Kaohsiung Med Ctr, Dept Neurol,Coll Med, Kaohsiung 833, Taiwan. [Schminke, Ulf] Ernst Moritz Arndt Univ Greifswald, Dept Neurol, D-17487 Greifswald, Germany. RP Tan, TY (reprint author), Chang Gung Univ, Chang Gung Mem Hosp, Kaohsiung Med Ctr, Dept Neurol,Coll Med, 123 Ta Pei Rd, Kaohsiung 833, Taiwan. 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Ultrasound PD SEP PY 2008 VL 36 IS 7 BP 432 EP 436 DI 10.1002/jcu.20505 PG 5 WC Acoustics; Radiology, Nuclear Medicine & Medical Imaging SC Acoustics; Radiology, Nuclear Medicine & Medical Imaging GA 341FB UT WOS:000258698500010 PM 18561342 ER PT J AU Walsh, SB Ekbal, N Brookes, J Cunningham, J AF Walsh, Stephen B. Ekbal, Nasirul Brookes, Jocelyn Cunningham, John TI Tinnitus after hemodialysis catheter placement SO KIDNEY INTERNATIONAL LA English DT Editorial Material C1 [Walsh, Stephen B.; Ekbal, Nasirul; Cunningham, John] Royal Free Hosp, Dept Nephrol, London NW3 2QG, England. [Brookes, Jocelyn] UCL Hosp, Dept Radiol, London, England. RP Walsh, SB (reprint author), Royal Free & Univ Coll Med Sch, Dept Physiol, Gower St, London WC1E 6BT, England. EM swalsh@medsch.ucl.ac.uk NR 0 TC 0 Z9 0 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0085-2538 J9 KIDNEY INT JI Kidney Int. PD SEP PY 2008 VL 74 IS 5 BP 688 EP 688 DI 10.1038/ki.2008.131 PG 1 WC Urology & Nephrology SC Urology & Nephrology GA 338TM UT WOS:000258531800023 PM 18709028 ER PT J AU Brawner, JT Thompson, A AF Brawner, James Travis Thompson, Ann TI Urocortin Expression in Mouse Cochlear Nucleus and Scarpa's Ganglion SO LARYNGOSCOPE LA English DT Article DE Urocortin; cochlear nucleus; stress-related peptides ID CORTICOTROPIN-RELEASING FACTOR; CENTRAL-NERVOUS-SYSTEM; BRAIN-STEM; SALICYLATE MODEL; RAT-BRAIN; TINNITUS; IMMUNOREACTIVITY; NEURONS; LOCALIZATION; RECEPTORS AB Objectives/Hypothesis: Clinical and basic studies have correlated tinnitus with stress. Although the etiology of tinnitus is unknown, the cochlear nucleus (CN) appears to play a role. To better understand the potential impact of stress on tinnitus and modulation of the central auditory system in general, the goal of the current study was to examine the presence and distribution of axon terminals containing urocortin in the CN of the mouse. Study Design: Prospective description of histological findings. Methods: Three different forms of urocortin were labeled in brainstem sections collected from 10 wild-type mice by immunohistochemistry. Immunoreactive terminal fibers in the CN were digitally photographed, as well as reconstructed in the CN under a drawing tube attached to a light microscope. Results: Specific staining was found in en passant type fibers scattered throughout the CN but situated mostly within the granule cell domains. Clusters of labeled fibers were observed in the nerve root. Labeled axons were observed in the three tracts known to carry olivocochlear fibers to the CN, as well as in the olivocochlear bundle itself. As the axons within the olivocochlear bundle departed the brainstem in the vestibular nerve, numerous labeled en passant fibers were observed among somata of the vestibular ganglion (Scarpa's). Centrally, labeled axons were followed from the CN to the lateral superior olive, an established source of urocortin-positive efferents to the cochlea. These findings indicate that lateral olivocochlear efferents innervate the CN and Scarpa's ganglion, and also that urocortin is likely a neuromodulator in particular CN circuits. Conclusions: The current study supports innervation of specific regions of the mouse CN and Scarpa's ganglion by neurons expressing urocortin. The innervation may be. one substrate by which stress modulates particular CN processes. Further studies are necessary to establish the role of urocortin in CN models of tinnitus. C1 [Brawner, James Travis; Thompson, Ann] Univ Oklahoma, Hlth Sci Ctr, Dept Otorhinolaryngol, Oklahoma City, OK 73190 USA. RP Thompson, A (reprint author), Univ Oklahoma, Hlth Sci Ctr, Dept Otorhinolaryngol, Oklahoma City, OK 73190 USA. 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The molecular features of this excitability, however, has been poorly characterized to date. Brain-derived neurotrophic factor (BDNF), the activity-dependent cytoskeletal protein (Arg3.1, also known as Arc), and c-Fos are known to be affected by changes in excitability and plasticity. Using reverse transcription-polymerase chain reaction, in situ hybridization, and immunohistochemistry, the expression of these genes was monitored in the rat auditory system after local (cochlear) and systemic application of salicylate. Induction of tinnitus and hearing loss was verified in a behavioral model. Regardless of the mode of salicylate application, a common pattern became evident: 1) BDNF mRNA expression was increased in the spiral ganglion neurons of the cochlea; and 2) Arg3.1 expression was significantly reduced in the auditory cortex. Local application of the GABA A receptor modulator midazolam resulted in the reversal not only of salicylate-induced changes in cochlear BDNF expression, but also in cortical Arg3.1 expression, indicating that the tinnitus-associated changes in cochlear BDNF expression trigger the decline of cortical Arg3.1 expression. Furthermore, local midazolam application reduced tinnitus perception in the animal model. These findings support Arg3.1 and BDNF as markers for activity changes in the auditory system and suggest a role of GABAergic inhibition of cochlear neurons in the modulation of Arg3.1 plasticity changes in the auditory cortex and tinnitus perception. C1 [Knipper, Marlies] Univ Tubingen, HNO Klin, Dept Otorhinolaryngol, Hearing Res Ctr Tubingen, D-72076 Tubingen, Germany. [Oestreicher, Elmar] Private ENT Clin, Meppen, Germany. RP Knipper, M (reprint author), Univ Tubingen, HNO Klin, Dept Otorhinolaryngol, Hearing Res Ctr Tubingen, Elfriede Aulhorn Str 5, D-72076 Tubingen, Germany. 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Pharmacol. PD SEP PY 2008 VL 74 IS 3 BP 595 EP 604 DI 10.1124/mol.108.046375 PG 10 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA 340HU UT WOS:000258637500007 PM 18524887 ER PT J AU Chou, CH Lin, JC Hsueh, CJ Peng, GS AF Chou, Chung-Hsing Lin, Jiann-Chyun Hsueh, Chun-Jen Peng, Giia-Sheun TI A thrombophilic patient with a dural arteriovenous fistula presenting sensory aphasia and complicated with an acute pulmonary embolism SO NEUROLOGIST LA English DT Article DE dural arteriovenous fistula; pulmonary embolism; thrombophilia AB Background: Neuropsychiatric symptoms as the initial presentation of dural arteriovenous fistula (DAVF) are unusual. Anticoagulation therapy may be warranted for prevention of further thromboembolism if an underlying thrombophilia condition is diagnosed. Case Report: We present a 70-year-old woman with sensory aphasia, who was diagnosed with a DAVF, Cognard type II a + b, by cerebral angiography. Her stroke-like syndrome resolved after transarterial embolization of the left occipital and middle meningeal arteries. Meanwhile, hypercoagulability was found because of hyperhomocysteinemia and the presence of a lupus anticoagulant. One month later, she suffered an acute pulmonary embolism and was started on anticoagulation therapy before stereotactic radiosurgery. Conclusion: Sensory aphasia may be the initial manifestation of a transverse-sigmoid sinus DAVF even if there are no symptoms such as headache or tinnitus. We postulate that early anticoagulation therapy is indicated for preventing thromboembolism in DAVF patients with thrombophilia because the possibility of intracranial bleeding has been reduced by embolization. C1 [Chou, Chung-Hsing; Lin, Jiann-Chyun; Peng, Giia-Sheun] Tri Serv Gen Hosp, Natl Def Med Ctr, Dept Neurol, Taipei 114, Taiwan. [Hsueh, Chun-Jen] Tri Serv Gen Hosp, Natl Def Med Ctr, Dept Radiol, Taipei 114, Taiwan. 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TI NEUROLOGICAL COMPLICATIONS OF CHRONIC MYELOID LEUKAEMIA: ANY CURE? SO NIGERIAN JOURNAL OF CLINICAL PRACTICE LA English DT Article DE Neurological complications; chronic myeloid leukaemia; cure AB Objective: To attempt to explain the non-reversal, contrary to the widely held view, of the neurological deficits complicating chronic myeloid leukaemia. Method: Using patients' case folders and haematological malignancy register all cases of chronic myeloid leukaemia seen in Jos University Teaching Hospital between July 1995 and June 2005 were retrospectively studied. All the available literature on the subject was also reviewed. Results: Thirty-three cases of chronic myeloid leukaemia were seen within the study period. Five (15.15%) of them had one or more sensori-neural defects. Of the five, two (40%) patients presented with bilateral hearing impairment, each beginning with the left ear; one (20%) presented with left ear hearing loss; one (20%) came with severe left ear tinnitus; one (20%) presented with complete bilateral hearing and bilateral visual losses. Fundoscopy showed leukaemic deposits on the retina. Other causes of blindness and deafness, e.g. trauma and foreign body in the ear respectively, were excluded. Conclusion: While the complications due to hyperleucocytosis-induced stasis recover following the conventional treatment, those due to other pathogenetic mechanisms such as leukaemic deposits do not return to their pre-morbid states following disease control despite the use of the currently available treatment protocols. For future research, more still needs to be done to elicit other uncommon pathogenetic mechanisms underlying these complications with a view to finding specific treatment measures for worrisome chronic myeloid leukaemia-related sensori-neural deficits. C1 [Emmanuel, J. D.] Univ Jos, Teaching Hosp, Dept Haematol, Jos, Nigeria. [Emmanuel, J. D.] Univ Jos, Teaching Hosp, Dept Blood Transfus, Jos, Nigeria. [Dorusinmi, M. A.] Obafemi Awolowo Univ, Ife, Nigeria. RP Emmanuel, JD (reprint author), Univ Jos, Teaching Hosp, Dept Haematol, Jos, Nigeria. 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PD SEP PY 2008 VL 11 IS 3 BP 246 EP 249 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA 386YK UT WOS:000261918300014 ER PT J AU Del Bo, L Forti, S Ambrosetti, U Costanzo, S Mauro, D Ugazio, G Langguth, B Mancuso, A AF Del Bo, Luca Forti, Stella Ambrosetti, Umberto Costanzo, Serena Mauro, Davide Ugazio, Gregorio Langguth, Berthold Mancuso, Antonio TI Tinnitus aurium in persons with normal hearing: 55 years later SO OTOLARYNGOLOGY-HEAD AND NECK SURGERY LA English DT Article AB OBJECTIVE: The aim of this study was to investigate the effect of silence on the appearance of auditory phantom perceptions in normal-hearing adults, with specific emphasis on the influence of suggestion. STUDY DESIGN: Cross-sectional survey. SUBJECTS AND METHODS: Fifty-three normal-hearing young Caucasian adults were subjected to two 4-minute sessions in an anechoic sound chamber. In the first session the chamber was empty; in the second session the chamber contained a nonfunctioning loud-speaker. At the end of each session, subjects had to indicate which sounds they perceived from a list of 23 different sounds. RESULTS: When the loudspeaker was not present, 83 percent of the participants reported that they experienced at least one sound, and the percentage increased to 92 percent when the loudspeaker was present. CONCLUSION: These results confirm the emergence of tinnituslike perceptions in a nonclinical population in a silent environment and indicate that suggestive mechanisms play only a minor role in their generation. (c) 2008 American Academy of Otolaryngology-Head and Neck Surgery Foundation. All rights reserved. C1 [Del Bo, Luca; Costanzo, Serena; Ugazio, Gregorio] Univ Milan, Fdn Ascolta & Vivi, Fdn IRCCS Osped Maggiore Policlin Mangiagalli & R, I-20144 Milan, Italy. 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PD SEP PY 2008 VL 139 IS 3 BP 391 EP 394 DI 10.1016/j.otohns.2008.06.019 PG 4 WC Otorhinolaryngology; Surgery SC Otorhinolaryngology; Surgery GA 343MP UT WOS:000258858400011 PM 18722219 ER PT J AU Przewozny, T Gasecki, D Narozny, W Nyka, W AF Przewozny, Tomasz Gasecki, Dariusz Narozny, Waldemar Nyka, Walenty TI Risk factors of sensorineural hearing loss in patients with ischemic stroke SO OTOLOGY & NEUROTOLOGY LA English DT Article DE ischemic stroke; lacunar stroke; risk factor; sensorineural hearing loss; tinnitus ID HEMATOLOGIC DISORDERS; BILATERAL DEAFNESS; INFARCTION; DISEASE AB Objectives: We investigated risk factors of sensorineural hearing loss (SHL) in patients with early stage of ischemic stroke (IS). Methods: Our Study consisted of 60 patients with IS who were treated at Department of Neurology, Medical University of Gdansk between 2006 and 2007. A multivariate stepwise linear regression was used to identify the risk factors that were related to SIAL as measured by pure-tone average (0.5, 1, and 2 kHz), the high-tone average (4, 6, and 8 kHz), the pure-tone middle-tone average (0.5, 1 2, and 4 kHz), and the overall average (0.5, 1, 2, 4 6, and 8 kHz). The following factors were included in the analysis: age, sex, smoking habit, addiction to alcohol, presence of tinnitus and vestibular symptoms, arterial hypertension, cardiac ischemic disease, hyperlipidemia, diabetes. number of risk factors, neurologic state at the admission. localization of stroke, cause of stroke, number of ischemic focuses, the side and diameter of ischemic focuses, the result of directional hearing acuity angle test, results of certain laboratory tests, blood morphology parameters, and coagulogram. Values for p less than 0.05 were considered significant. Results: Our analysis suggests the presence of the following risk factors of SHL in patients with IS: 1) older age (>60 yr); 2) male sex; 3) presence of tinnitus; 4) arterial hypertension; 5) lacunar type of stroke; 6) presence of multiple ischemic focuses; 7) presence of bilateral ischemic focuses; 8) changes in blood cell count; and 9) disturbances of agglutination. Conclusion: The highest risk of hearing loss in the group of IS patients occurred at older people, particularly men with tinnitus, lacunar stroke, multiple, bilateral ischemic focuses, and arterial hypertension. A negative statistically significant influence of decreased level of red cells, platelets, and hematocrit value on hearing loss was found. Abnormally lowered levels of activated partial thromboplastin time, activated partial thromboplastin time ratio, prothrombin index, and abnormal lowered level of international normalized ratio statistically impaired hearing. C1 [Przewozny, Tomasz; Narozny, Waldemar] Med Univ Gdansk, Dept ENT, PL-80211 Gdansk, Poland. [Gasecki, Dariusz; Nyka, Walenty] Med Univ Gdansk, Dept Neurol, PL-80211 Gdansk, Poland. RP Przewozny, T (reprint author), Med Univ Gdansk, Dept ENT, 7 Debinki Str, PL-80211 Gdansk, Poland. EM tprzew@amg.gda.pl CR Bauer Carol A, 2004, Curr Opin Otolaryngol Head Neck Surg, V12, P413, DOI 10.1097/01.moo.0000134443.29853.09 Ben-David J, 2001, Int Tinnitus J, V7, P62 Cadoni G, 2006, ANN OTO RHINOL LARYN, V115, P195 Cerrato P, 2005, NEUROLOGY, V65, P1840, DOI 10.1212/01.wnl.0000187083.90889.72 Deplanque D, 1998, J NEUROL NEUROSUR PS, V64, P817 EINER H, 1994, ARCH OTOLARYNGOL, V120, P536 Gates GA, 1996, ARCH OTOLARYNGOL, V122, P161 GAZZANIGA M S, 1973, Cortex, V9, P136 GOLDSTEIN MN, 1975, BRAIN LANG, V2, P324, DOI 10.1016/S0093-934X(75)80073-3 Griest S E, 1998, AAOHN J, V46, P325 HARIRI MA, 1994, AGE AGEING, V23, P312, DOI 10.1093/ageing/23.4.312 HART RG, 1990, STROKE, V21, P1111 Hong O S, 2001, ORL Head Neck Nurs, V19, P7 HUANG MH, 1993, STROKE, V24, P132 JERGER J F, 1960, AMA Arch Otolaryngol, V71, P797 Kalisa P, 2001, B SOC BELGE OPHTALMO, V282, P5 Kannel W B, 1995, Hypertens Res, V18, P181, DOI 10.1291/hypres.18.181 Lee H, 2001, ARCH NEUROL-CHICAGO, V58, P1287, DOI 10.1001/archneur.58.8.1287 Marcucci R, 2005, J THROMB HAEMOST, V3, P929, DOI 10.1111/j.1538-7836.2005.01310.x Mercier E, 1999, BLOOD, V93, P3150 Narozny W, 2006, ANN OTO RHINOL LARYN, V115, P553 NEUBERGER M, 1992, AUDIOLOGY, V31, P45 OGAWA K, 1994, ACTA OTO-LARYNGOL, P85 Rey JF, 2002, ACTA OTORRINOLARINGO, V53, P572 Rudack C, 2006, THROMB HAEMOSTASIS, V95, P454, DOI 10.1160/TH05-08-0554 Schick B, 2001, OTOL NEUROTOL, V22, P808, DOI 10.1097/00129492-200111000-00016 Suckfull M, 2002, OTOL NEUROTOL, V23, P309, DOI 10.1097/00129492-200205000-00013 Toyoda K, 2002, J NEUROL SCI, V193, P147, DOI 10.1016/S0022-510X(01)00663-3 WEKSLER BB, 1995, CURR OPIN NEUROL, V8, P38, DOI 10.1097/00019052-199502000-00007 WOLF PA, 1991, STROKE, V22, P312 Yamasoba T, 2001, J NEUROL SCI, V187, P69, DOI 10.1016/S0022-510X(01)00525-1 NR 31 TC 3 Z9 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1531-7129 J9 OTOL NEUROTOL JI Otol. Neurotol. PD SEP PY 2008 VL 29 IS 6 BP 745 EP 750 DI 10.1097/MAO.0b013e318181336c PG 6 WC Clinical Neurology; Otorhinolaryngology SC Neurosciences & Neurology; Otorhinolaryngology GA 346MF UT WOS:000259071900002 PM 18636032 ER PT J AU Teggi, R Lanzani, C Zagato, L Carpini, SD Manunta, P Bianchi, G Bussi, M AF Teggi, Roberto Lanzani, Chiara Zagato, Laura Carpini, Simona Delli Manunta, Paolo Bianchi, Giuseppe Bussi, Mario TI Gly460Trp alpha-adducin mutation as a possible mechanism leading to endolymphatic hydrops in Meniere's syndrome SO OTOLOGY & NEUROTOLOGY LA English DT Article DE adducin; endolymph; inner ear; Meniere's disease; Na+, K+-ATPase ID K-CL COTRANSPORTER; GUINEA-PIG; INNER-EAR; DISEASE; GENE; LOCALIZATION; DEAFNESS; ATPASE; WALL; MICE AB Objective: Meniere's disease (MD) is an inner ear disorder characterized by recurrent episodic vertigo.. hearing loss that is fluctuating in the first stages, aural fullness, and tinnitus. Raised endolymphatic pressure (hydrops) is commonly accepted as a causal condition. Approximately 90% of cases of MD are sporadic, whereas the remaining 10% of cases are linked to genetic factors. The ionic composition of endolymph may also depend on the activity of Na+, K+-ATPase. Adducin is a heterodimeric cytoskeleton protein consisting of 3 Subunits (alpha, beta, and gamma) coded by 3 different genes (ADD1, ADD2, and ADD3). ADD 1 Gly460Trp polymorphism, is associated with salt-sensitive hypertension and increased Na+-K+ pump activity in transfected cells. This study aims to verify the role of adducin in the development of MD. Methods: We genotyped 28 patients affected by definite MD according to American Academy of Otolaryngology-Head and Neck Surgery Foundation criteria. Results were compared with those from 2 different control populations (nonnotensive control group from San Raffaele Hospital and general population group). Results: We have not found any significant difference in the distribution of ADD2 C1797T and ADD3 IVS11+386A/G polymorphism genotypes. On the other hand, the frequency of ADD1 Trp allele is significantly increased in patients with MD compared with controls. Conclusion: We present data supporting the possibility that increased Na+. K+-ATPase activity may be one of the pathologic mechanisms inducing hyperosmolarity in endolymph which, in turn, may lead to hydrops. C1 [Teggi, Roberto; Bussi, Mario] Univ Vita Salute San Raffaele, ENT Dept, Milan, Italy. [Lanzani, Chiara; Zagato, Laura; Carpini, Simona Delli; Manunta, Paolo; Bianchi, Giuseppe] Univ Vita Salute San Raffaele, San Raffaele Sci Inst, Div Nephrol Dialysis & Hypertens, Milan, Italy. RP Teggi, R (reprint author), Hosp San Raffaele, Via Olgettina 60, I-20132 Milan, Italy. 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Neurotol. PD SEP PY 2008 VL 29 IS 6 BP 824 EP 828 DI 10.1097/MAO.0b013e318180a4b1 PG 5 WC Clinical Neurology; Otorhinolaryngology SC Neurosciences & Neurology; Otorhinolaryngology GA 346MF UT WOS:000259071900015 PM 18667944 ER PT J AU El Refaie, A Davis, A Kayan, A Baskill, J Owen, V AF El Refaie, A. Davis, A. Kayan, A. Baskill, J. Owen, V TI Quality of life issues in tinnitus sufferers: Prospective study on illness perception SO PSYCHOLOGY & HEALTH LA English DT Meeting Abstract C1 [El Refaie, A.; Davis, A.; Kayan, A.; Baskill, J.; Owen, V] Univ Bristol, Bristol BS8 1TH, Avon, England. NR 0 TC 0 Z9 0 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 0887-0446 J9 PSYCHOL HEALTH JI Psychol. Health PD SEP PY 2008 VL 23 BP 110 EP 111 PG 2 WC Public, Environmental & Occupational Health; Psychology, Multidisciplinary SC Public, Environmental & Occupational Health; Psychology GA 360GZ UT WOS:000260047300235 ER PT J AU De Ridder, D Menovsky, T Van Laer, C de Heyning, PV AF De Ridder, Dirk Menovsky, Tomas Van Laer, Carl de Heyning, Paul Van TI Remote tentorium meningioma causing sudden sensorineural deafness SO SURGICAL NEUROLOGY LA English DT Article DE microvascular compression; meningioma; neurovascular compression; overcrowding; sudden sensorineural deafness ID POSTERIOR CRANIAL FOSSA; TRIGEMINAL NEURALGIA; MICROVASCULAR DECOMPRESSION; HEARING-LOSS; CEREBELLOPONTINE ANGLE; COCHLEAR NERVE; TUMORS; COMPRESSION; TINNITUS; FREQUENCY AB Background: Sudden sensorineural deafness is a well-known symptom mostly of unknown etiology. Case Description: A case of sudden sensorineural deafness is reported to be caused by a small, remote, ipsilateral tentorial meningioma not compressing the vestibulocochlear nerve or auditory tract. Surgical resection of the meningioma immediately restored the patient's hearing. Conclusion: The authors hypothesize that the sudden sensorineural deafness resulted front a growing meningioma inducing a neurovascular compression of the vestibulocochlear nerve, the vertebral artery already being in close relationship with the vestibulocochlear nerve in the premorbid phase. Resection of the meningioma allows for an autodecompression of this vascular conflict resulting in hearing restoration. (c) 2008 Elsevier Inc. All rights reserved. C1 [De Ridder, Dirk; Menovsky, Tomas] Univ Antwerp Hosp, Dept Neurosurg, B-2650 Edegem, Belgium. [Van Laer, Carl; de Heyning, Paul Van] Univ Antwerp Hosp, Dept ENT, B-2650 Edegem, Belgium. 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Neurol. PD SEP PY 2008 VL 70 IS 3 BP 312 EP 318 DI 10.1016/j.surneu.2007.04.014 PG 7 WC Clinical Neurology; Surgery SC Neurosciences & Neurology; Surgery GA 342GH UT WOS:000258772100013 PM 18261778 ER PT J AU Bauer, CA Turner, JG Caspary, DM Myers, KS Brozoski, TJ AF Bauer, Carol A. Turner, Jeremy G. Caspary, Donald M. Myers, Kristin S. Brozoski, Thomas J. TI Tinnitus and inferior colliculus activity in chinchillas related to three distinct patterns of cochlear trauma SO JOURNAL OF NEUROSCIENCE RESEARCH LA English DT Article DE acoustic trauma; carboplatin; cisplatin; spontaneous unit activity; silicon-substrate electrodes; chinchillas; tinnitus ID HAIR CELL LOSS; SPONTANEOUS NEURAL ACTIVITY; STEM AUDITORY NUCLEI; PURE-TONE TRAUMA; HEARING-LOSS; GUINEA-PIG; ACOUSTIC TRAUMA; ADULT CATS; MODEL; LESIONS AB A longstanding hypothesis is that tinnitus, the perception of sound without an external acoustic source, is triggered by a distinctive pattern of cochlear hair cell (HC) damage and that this subsequently leads to altered neural activity in the central auditory pathway. This hypothesis was tested by assessing behavioral evidence of tinnitus and spontaneous neural activity in the inferior colliculus (IC) after unilateral cochlear trauma. Chinchillas were assigned to four cochlear treatment groups. Each treatment produced a distinctive pattern of HC damage, as follows: acoustic exposure (AEx): sparse low-frequency inner hair cell (IHC) and outer hair cell (OHC) loss; round window cisplatin (CisEx): pronounced OHC loss mixed with some IHC loss; round window carboplatin (CarbEx): pronounced IHC loss without OHC loss; control: no loss. Compared with controls, all experimental groups displayed significant and similar psychophysical evidence of tinnitus with features resembling a 1-kHz tone. Contralateral IC spontaneous activity was elevated in the AEx and CisEx groups, which showed increased spiking and increased cross-fiber synchrony. A multidimensional analysis identified a subpopulation of neurons more prevalent in animals with tinnitus. These units were characterized by high bursting, low ISI variance, and within-burst peak spiking of approximately 1,000/sec. It was concluded that cochlear trauma in general, rather than its specific features, leads to multiple changes in central activity that underpin tinnitus. Particularly affected was a subpopulation ensemble of IC neurons with the described unique triad of features. (c) 2008 Wiley-Liss, Inc. C1 [Bauer, Carol A.; Turner, Jeremy G.; Myers, Kristin S.; Brozoski, Thomas J.] So Illinois Univ, Sch Med, Div Otolaryngol Head & Neck Surg, Springfield, IL USA. [Caspary, Donald M.] So Illinois Univ, Sch Med, Dept Pharmacol, Springfield, IL 62794 USA. [Turner, Jeremy G.] Illinois Benedictine Coll, Dept Psychol, Jacksonville, IL USA. RP Brozoski, TJ (reprint author), POB 19629,801 N Rutledge St,Rm 3205, Springfield, IL 62794 USA. 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Neurosci. Res. PD AUG 15 PY 2008 VL 86 IS 11 BP 2564 EP 2578 DI 10.1002/jnr.21699 PG 15 WC Neurosciences SC Neurosciences & Neurology GA 338AU UT WOS:000258478100021 PM 18438941 ER PT J AU Sajjadi, H Paparella, MM AF Sajjadi, Hamed Paparella, Michael M. TI Meniere's disease SO LANCET LA English DT Article ID SENSORINEURAL HEARING-LOSS; ENDOLYMPHATIC SAC SURGERY; INTRATYMPANIC GENTAMICIN TREATMENT; VESTIBULAR NERVE-SECTION; MEDICAL-MANAGEMENT; PRESSURE CHAMBER; VERTIGO; PATHOGENESIS; SYMPTOMS; THERAPY AB Meniere's disease is a chronic illness that affects a substantial number of patients every year worldwide. The disease is characterised by intermittent episodes of vertigo lasting from minutes to hours, with fluctuating sensorineural hearing loss, tinnitus, and aural pressure. Although there is currently no cure, more than 85% of patients with Meniere's disease are helped by either changes in lifestyle and medical treatment, or minimally invasive surgical procedures such as intratympanic steroid therapy, intratympanic gentamicin therapy, and endolymphatic sac surgery. Vestibular neurectomy has a very high rate of vertigo control and is available for patients with good hearing who have failed all other treatments. Labyrinthectomy is undertaken as a last resort and is best reserved for patients with unilateral disease and deafness. C1 [Sajjadi, Hamed] Stanford Univ, Med Ctr, Dept Otolaryngol Head & Neck Surg, San Jose, CA 95124 USA. [Paparella, Michael M.] Univ Minnesota, Dept Otolaryngol Head & Neck Surg, Minneapolis, MN USA. RP Sajjadi, H (reprint author), Stanford Univ, Med Ctr, Dept Otolaryngol Head & Neck Surg, 2577 Samaritan Dr,Ste 845, San Jose, CA 95124 USA. 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P65 NR 99 TC 88 Z9 102 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0140-6736 J9 LANCET JI Lancet PD AUG 2 PY 2008 VL 372 IS 9636 BP 406 EP 414 DI 10.1016/S0140-6736(08)61161-7 PG 9 WC Medicine, General & Internal SC General & Internal Medicine GA 334AZ UT WOS:000258196000032 PM 18675691 ER PT J AU Kallio, H Niskanen, ML Havia, M Neuvonen, PJ Rosenberg, PH Kentala, E AF Kallio, H. Niskanen, M. L. Havia, M. Neuvonen, P. J. Rosenberg, P. H. Kentala, E. TI IV ropivacaine compared with lidocaine for the treatment of tinnitus SO BRITISH JOURNAL OF ANAESTHESIA LA English DT Article DE anaesthetic techniques, i.v. infusion; anaesthetics local, lidocaine; anaesthetics local, ropivacaine; toxicity, local anaesthetics ID INTRAVENOUS LIDOCAINE; LOCAL-ANESTHETICS; CHRONIC PAIN; BUPIVACAINE; INFUSIONS; VOLUNTEERS; PLACEBO; SYSTEM AB Background. I.V. lidocaine has been used to ameliorate tinnitus, but in general its effect has been limited. The longer acting local anaesthetic ropivacaine may be more effective. Methods. A total of 19 randomized, double-blind, cross-over study patients suffering from chronic tinnitus were given a 30 min i.v. infusion of ropivacaine or lidocaine 1.5 mg kg(-1) at an interval of 2-3 months. The intensity of tinnitus was evaluated on tinnitus handicap inventory (THI) scale and on the visual analogue scale (VAS). Plasma ropivacaine and lidocaine concentrations were determined. Results. In both treatments, the infusion decreased the VAS score significantly. At the end of infusion, a >= 50% reduction in VAS score was observed in five patients by ropivacaine and in one patient by lidocaine, but this effect was sustained for 1 h only in three patients. However, the THI scores did not differ significantly within or between treatments. On the post-infusion day, three patients after ropivacaine and five after lidocaine treatment had >= 30% improvement in the THI score. Four weeks later, one patient after ropivacaine and two after lidocaine had a >= 30% reduction in the THI score. One patient developed seizures soon after ropivacaine infusion from which he recovered uneventfully. His plasma concentration of ropivacaine was 1817 ng ml(-1). The highest individual ropivacaine and lidocaine concentrations were 3483 and 1680 ng ml(-1), respectively. Conclusions. Temporary clinically significant alleviation of tinnitus was observed only in a few individuals after both i.v. ropivacaine and lidocaine. The toxicity of ropivacaine limits its usefulness. C1 [Kallio, H.; Niskanen, M. L.; Rosenberg, P. H.] Helsinki Univ Cent Hosp Anaesthesia, Hosp Eye, Dept Anaesthesiol & Intens Care Med, Helsinki 00029, HUS, Finland. [Havia, M.; Kentala, E.] Helsinki Univ Cent Hosp Anaesthesia, Hosp Eye, Audiol Unit, Dept Otorhinolaryngol, Helsinki 00029, HUS, Finland. [Neuvonen, P. J.] Helsinki Univ Cent Hosp Anaesthesia, Hosp Eye, Dept Clin Pharmacol, Helsinki 00029, HUS, Finland. RP Kallio, H (reprint author), Helsinki Univ Cent Hosp Anaesthesia, Hosp Eye, Dept Anaesthesiol & Intens Care Med, Haartmanstr 4,POB 220, Helsinki 00029, HUS, Finland. 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J. Anaesth. PD AUG PY 2008 VL 101 IS 2 BP 261 EP 265 DI 10.1093/bja/aen137 PG 5 WC Anesthesiology SC Anesthesiology GA 325GE UT WOS:000257576200022 PM 18522937 ER PT J AU Yu, N Zhu, ML Johnson, B Liu, YP Jones, RO Zhao, HB AF Yu, N. Zhu, M. -L. Johnson, B. Liu, Y. -P. Jones, R. O. Zhao, H. -B. TI Prestin up-regulation in chronic salicylate (aspirin) administration: An implication of functional dependence of prestin expression SO CELLULAR AND MOLECULAR LIFE SCIENCES LA English DT Article DE prestin; outer hair cell electromotility; salicylate; aspirin; functional dependence; hearing; tinnitus ID OUTER HAIR CELL; AUDITORY-PERCEPTION TINNITUS; MOTILITY VOLTAGE SENSOR; MOTOR PROTEIN PRESTIN; GUINEA-PIG; MECHANICAL RESPONSES; ANIMAL-MODEL; MEMBRANE; ELECTROMOTILITY; GENERATION AB Salicylate (aspirin) can reversibly eliminate outer hair cell (OHC) electromotility to induce hearing loss. Prestin is the OHC electromotility motor protein. Here we report that, consistence with increase in distortion product otoacoustic emission, long-term administration of salicylate can increase prestin expression and OHC electromotility. The prestin expression at the mRNA and protein levels was increased by three- to four-fold. In contrast to the acute inhibition, the OHC electromotility associated charge density was also increased by 18%. This incremental increase was reversible. After cessation of salicylate administration, the prestin expression returned to normal. We also found that long-term administration of salicylate did not alter cyclooxygenase (Cox) II expression but down-regulated NF-kappa B and increased nuclear transcription factors c-fos and egr-1. The data suggest that prestin expression in vivo is dynamically up-regulated to increase OHC electromotility in long-term administration of salicylate via the Cox-II-independent pathways. C1 [Yu, N.; Zhu, M. -L.; Johnson, B.; Liu, Y. -P.; Jones, R. 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Mol. Life Sci. PD AUG PY 2008 VL 65 IS 15 BP 2407 EP 2418 DI 10.1007/s00018-008-8195-y PG 12 WC Biochemistry & Molecular Biology; Cell Biology SC Biochemistry & Molecular Biology; Cell Biology GA 335FJ UT WOS:000258275900012 PM 18560754 ER PT J AU Yap, L Pothula, VB Lesser, T AF Yap, L. Pothula, V. B. Lesser, T. TI Microvascular decompression of cochleovestibular nerve SO EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY LA English DT Review DE eighth cranial nerve; cochleovestibular neurovascular compression; microvascular decompression; vertigo; tinnitus ID DISABLING POSITIONAL VERTIGO; 8TH CRANIAL NERVE; VASCULAR COMPRESSION SYNDROME; RESONANCE TOMOGRAPHIC ANGIOGRAPHY; AUDITORY EVOKED-POTENTIALS; TRIGEMINAL NEURALGIA; NEUROVASCULAR COMPRESSION; COCHLEAR NERVE; HEMIFACIAL SPASM; SELECTION CRITERIA AB The role of microvascular decompression (MVD) in the management of trigeminal neuralgia, hemifacial spasms and glossopharyngeal neuralgia is well-established. However, controversy persisted as to the use of MVD in cochleovestibular neurovascular compression syndrome. This report provides a review of all the published studies on MVD of the eighth (8th) nerve in alleviating cochleovestibular symptoms and presents three additional patients who underwent MVD of the eighth nerve for tinnitus or vertigo. Nineteen studies were identified. Five were case reports. The remaining have sample sizes ranging from 4 to 207 patients. Quantitative and qualitative reviews of all studies were performed, focusing on the selection criteria for surgery, efficacy and safety of the procedure. Selection criteria for surgery were variable. No standardised outcome measures were used and all studies rely on patient subjective assessment of surgical outcome. Nonetheless, the results suggest that MVD of the eighth nerve produces good outcome with low morbidity in selected cases. C1 [Yap, L.] Walton Ctr Neurol & Neurosurg, Liverpool, Merseyside, England. [Pothula, V. 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Arch. Oto-Rhino-Laryn. PD AUG PY 2008 VL 265 IS 8 BP 861 EP 869 DI 10.1007/s00405-008-0647-3 PG 9 WC Otorhinolaryngology SC Otorhinolaryngology GA 314PZ UT WOS:000256822600003 PM 18389269 ER PT J AU Ozturkcan, S Katilmis, H Ozkul, Y Erdogan, N Basoglu, S Tayfun, MA AF Ozturkcan, Sedat Katilmis, Hueseyin Ozkul, Yilmaz Erdogan, Nezahat Basoglu, Sinan Tayfun, Mehmet Ali TI Surgical treatment of the high jugular bulb by compressing sinus sigmoideus: two cases SO EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY LA English DT Article DE high jugular bulb; sigmoid sinus; compression; embolization ID MIDDLE-EAR; TINNITUS; SURGERY AB If the jugular bulb normally surrounded by a bony layer in jugular fossa is anatomically over the inferior surface of the bony annulus, in the middle ear or over the basal turn of cochlea, it is then named as high jugular bulb (HJB). It may be dehiscent or aberrant. It is reported to occur in 5% of the temporal bone specimens. In accordance with the literature jugular bulb compression, jugular vein ligation and embolization are suggested in such cases. In both of the presented cases, there was bleeding from jugular bulb during surgery and jugular bulb was compressed with bone wax and Surgicel, but sigmoid sinus has been compressed after failure to stop bleeding through jugular bulb compression. Venous MR angiographies showed no flow in postoperative controls. Although it is very rarely seen clinically, we present two HJB cases and different treatment perspectives accompanied by literature. C1 [Ozturkcan, Sedat; Katilmis, Hueseyin; Ozkul, Yilmaz; Basoglu, Sinan; Tayfun, Mehmet Ali] Ataturk Training & Res Hosp, Minist Hlth, Dept Otorhinolaryngol Head & Neck Surg, Izmir, Turkey. [Erdogan, Nezahat] Ataturk Training & Res Hosp, Minist Hlth, Dept Radiol, Izmir, Turkey. RP Ozturkcan, S (reprint author), Izmir Ataturk Egitim Arastirma Hastanesi 2, KBB Klin, Izmir, Turkey. 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Arch. Oto-Rhino-Laryn. PD AUG PY 2008 VL 265 IS 8 BP 987 EP 991 DI 10.1007/s00405-007-0545-0 PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA 314PZ UT WOS:000256822600023 PM 18046566 ER PT J AU Balbastre, A Lainez, MJ Paula, C Marco, J Lopez, B AF Piera Balbastre, A. Lainez, M. J. Paula, C. Marco, J. Lopez, B. TI Pregabalin: a potential drug for chronic tinnitus treatment SO EUROPEAN JOURNAL OF NEUROLOGY LA English DT Meeting Abstract CT 12th Congress of the European-Federation-of-Neurological-Societies CY AUG 23-26, 2008 CL Madrid, SPAIN SP European Federat Neurol Soc C1 [Piera Balbastre, A.; Lainez, M. J.; Lopez, B.] Hosp Clin Univ Valencia, Dept Neurol, Valencia, Spain. [Paula, C.; Marco, J.] Hosp Clin Univ Valencia, Dept Otol, Valencia, Spain. NR 0 TC 0 Z9 0 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1351-5101 J9 EUR J NEUROL JI Eur. J. Neurol. PD AUG PY 2008 VL 15 SU 3 BP 383 EP 383 PG 1 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA 336QF UT WOS:000258379001268 ER PT J AU Zhai, GD Pang, Q Guo, H Xu, SC Wang, HB AF Zhai Guode Pang Qi Guo Hua Xu Shangchen Wang Hanbin TI Primary cerebellopontine angle angiosarcoma SO JOURNAL OF CLINICAL NEUROSCIENCE LA English DT Article DE angiosarcoma; cerebellopontine angle; histopathology; immunohistochemistry ID PRIMARY CEREBRAL ANGIOSARCOMA; OF-THE-LITERATURE; TUMORS; BRAIN; METASTASIS; SCALP; HEART; NECK; FACE AB Primary intracranial angiosarcomas are rare. Only a few cases have been reported in the literature. All cases reported were located in the supratentorial areas. To our knowledge, no cerebellopontine (CP) angle angiosarcoma has been reported. We report a 16-year-old girl who had mild headache, right-sided tinnitus and amblyacousia of 1-year's duration. She later developed abruptly severe headache and vomiting, accompanied by left hemiparesis, numbness, ataxia and bucking, and computerized tomography scan and magnetic resonance imaging were performed. There was a lesion in the right CP angle with haemorrhage and edema. The preoperative diagnosis was neurogenic tumor with haemorrhage. The patient underwent an emergency suboccipital craniectomy, and the lesion was excised completely. Histopathology and immunohistochemistry revealed an angiosarcoma. Postoperative radiotherapy was given. At the time of hospital discharge, she was in better clinical and neurological condition than her preoperative state. She has been followed up for 6 months and is is still in excellent condition without any sign of recurrence. This case report highlights that clinicians should be aware of the characteristics of angiosarcoma, and also stresses the need to include angiosarcoma in the differential diagnosis of rare lesions located in the CP angle. (c) 2007 Elsevier Ltd. All rights reserved. C1 [Zhai Guode; Pang Qi; Guo Hua; Xu Shangchen; Wang Hanbin] Shandong Univ, Shandong Prov Hosp, Dept Neurosurg, Jinan 250021, Peoples R China. RP Pang, Q (reprint author), Shandong Univ, Shandong Prov Hosp, Dept Neurosurg, Jinan 250021, Peoples R China. 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Clin. Neurosci. PD AUG PY 2008 VL 15 IS 8 BP 942 EP 946 DI 10.1016/j.jocn.2006.11.018 PG 5 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA 329LH UT WOS:000257868600022 ER PT J AU Stapleton, E Mills, R AF Stapleton, E. Mills, R. TI Clinical diagnosis of Meniere's disease: how useful are the American Academy of Otolaryngology Head and Neck Surgery Committee on Hearing and Equilibrium guidelines? SO JOURNAL OF LARYNGOLOGY AND OTOLOGY LA English DT Article DE Meniere's disease; otological diagnostic techniques; vertigo; tinnitus ID ELECTROCOCHLEOGRAPHY; RATIO AB Introduction: Meniere's disease is a diagnosis requiring expert clinical judgment. There are several differences between the American Academy of Otolaryngology Head and Neck Surgery diagnostic guidelines and Prosper Meniere's original description of the disease. Methods: Six hundred and fifty patients attending a specialist balance clinic had their clinical profiles fully analysed according to each set of diagnostic criteria. Results. Application of the American Academy of Otolaryngology Head and Neck Surgery guidelines resulted in the diagnosis of three times more patients than did use of Meniere's diagnostic criteria. Treatment options for patients in both groups were similar. It is unlikely that the application of different diagnostic criteria would have an effect on the treatment of individual patients. Discussion: The American Academy of Otolaryngology Head and Neck Surgery guidelines are more sensitive and less specific in diagnosing Meniere's disease than Prosper Meniere's original description. Standardised criteria should be applied across published series, in order to make results accurate, comparable and useful in the long term. We would recommend the introduction of a stricter diagnostic category for definite Meniere's disease. C1 [Stapleton, E.] Univ Edinburgh, Dept Otolaryngol, Otolaryngol Unit, Edinburgh EH3 9HA, Midlothian, Scotland. RP Stapleton, E (reprint author), Univ Edinburgh, Dept Otolaryngol, Otolaryngol Unit, Lauriston Bldg, Edinburgh EH3 9HA, Midlothian, Scotland. EM Emmastapleton@doctors.org.uk CR ARENBERG IK, 1980, OTOLARYNG CLIN N AM, V13, P643 ATKINSON M, 1961, ACTA OTO-LARYNGOL, V162, P1 BALKANY TJ, 1980, OTOLARYNG CLIN N AM, V13, P589 Committee on Hearing and Equilibirum, 1995, OTOLARYNGOL HEAD NEC, V113, P181 Committee on Hearing and Equilibrium, 1972, T AM ACAD OPHTHALMOL, V76, P1462 Committee on Hearing and Equilibrium, 1985, AAO HNS B, V5, P6 Conlon BJ, 2000, ACTA OTO-LARYNGOL, V120, P480, DOI 10.1080/000164800750045965 DOBIE RA, 1982, ACTA OTO-LARYNGOL, V94, P19, DOI 10.3109/00016488209128885 HAID CT, 1995, ACTA OTO-LARYNGOL, P251 Kim HH, 2005, OTOLARYNG HEAD NECK, V132, P722, DOI 10.1016/j.otohns.2005.01.007 Levine S, 1998, LARYNGOSCOPE, V108, P993, DOI 10.1097/00005537-199807000-00008 Meniere P., 1861, GAZ MED PARIS, V16, P29 OHASHI T, 1989, ORL J OTO-RHINO-LARY, V51, P235 Olesen J, 2005, FUNCT NEUROL, V20, P61 Pearsall Judy, 2001, NEW OXFORD DICT ENGL PEARSON BW, 1985, OTOLARYNG HEAD NECK, V93, P579 RIDENOUR BD, 1993, AM J OTOLARYNG, V14, P24, DOI 10.1016/0196-0709(93)90006-S ROSE AS, 1976, NEUROLOGY, V26, P20 RUTKA JA, 1986, J OTOLARYNGOL, V15, P105 Schuknecht H F, 1983, Ann Otol Rhinol Laryngol Suppl, V106, P1 Stahle J, 1981, Am J Otol, V2, P357 STAPLETON E, 2007, BRIT MED J, V334, P361, DOI 10.1136/bmj.39087.611192.BE Thorp MA, 2003, CLIN OTOLARYNGOL, V28, P173, DOI 10.1046/j.1365-2273.2003.00687.x WEXLER DB, 1991, LARYNGOSCOPE, V101, P50 NR 24 TC 2 Z9 3 PU CAMBRIDGE UNIV PRESS PI CAMBRIDGE PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND SN 0022-2151 J9 J LARYNGOL OTOL JI J. Laryngol. Otol. PD AUG PY 2008 VL 122 IS 8 BP 773 EP 779 DI 10.1017/S0022215107000771 PG 7 WC Otorhinolaryngology SC Otorhinolaryngology GA 336QP UT WOS:000258380000002 PM 17931446 ER PT J AU Ologe, FE Olajide, TG Nwawolo, CC Oyejola, BA AF Ologe, F. E. Olajide, T. G. Nwawolo, C. C. Oyejola, B. A. TI Deterioration of noise-induced hearing loss among bottling factory workers SO JOURNAL OF LARYNGOLOGY AND OTOLOGY LA English DT Article DE Nigeria; deafness; noise; disease prevention; screening; audiornetry ID STEEL ROLLING-MILL; EXPOSURE; TINNITUS AB Background: Repeated exposure to excessive noise will eventually lead to an irreversible increase in hearing thresholds. In theory, the damage reflects both the intensity of the noise and the duration of exposure. This is not linear with respect to duration of exposure; rather, the worker may experience a disproportionate loss in the early years of exposure. Methods: A prospective study surveying workers of the production section (i.e. most noise-exposed area) of a bottling factory was carried out in December 2003 and in December 2005. A self-administered questionnaire was used to extract information about worker's demographic characteristics, drug intake, and medical and occupational history, as well as information on the use of hearing protection devices. Noise mapping of the various departments of the factory was carried out. Otological examination, tympanometry and audiometry were also carried out on selected subjects. Results: Eighty-four workers, 76 (90.5 per cent) men and eight (9.5 per cent) women, were studied. Their mean age was 33.0 +/- 7.6 years in 2003 and 35.0 +/- 7.6 years in 2005. The recorded noise levels in the factory production section ranged between 91.5 and 98.7 dBA. The prevalence of sensorineural hearing loss among workers was noted to be 64.9 and 86.9 per cent for test one (2003) and test two (2005), respectively. The degree of hearing deterioration within the two years of this study was 1.0-3.2 dB for the right ear and 1.6-3.4 dB for the left ear. This deterioration was at discrete frequencies. More than half (53.6 per cent) of the workers did not have a hearing protection device. Of the 46.4 per cent who did, only 38.5 per cent claimed to have used it regularly. Interpretation: These findings showed that there was a high prevalence of mild sensorineural hearing loss and significant hearing deterioration among workers, due to exposure to excessive noise over a two-year period. The study demonstrates the practical importance of serial audiometry for noise-exposed workers as a means of monitoring hearing deterioration. It is necessary to enforce existing occupational health laws in our industries in order to prevent noise-induced hearing loss, since it is eminently preventable. C1 [Ologe, F. E.] Univ Ilorin, Dept Otorhinolaryngol, Ilorin, Nigeria. [Oyejola, B. A.] Univ Ilorin, Dept Stat, Ilorin, Nigeria. [Olajide, T. G.] Fed Med Ctr, Dept Otorhinolaryngol, Iddo, Nigeria. [Nwawolo, C. C.] Univ Lagos, Otorhinolaryngol Unit, Dept Surg, Lagos, Nigeria. RP Ologe, FE (reprint author), POB 6641, Ilorin 240001, Nigeria. EM foluologe@yahoo.com RI Legarth, Jonas/A-9156-2012 CR Ahmed HO, 2001, ANN OCCUP HYG, V45, P371, DOI 10.1016/S0003-4878(00)00051-X AKANDE TM, 2001, TROPIC J HLTH SCI, V8, P28 ALBERTI PW, 1997, SCOTT BROWNS OTOLARY Avwiri G. O., 2003, Journal of Applied Sciences & Environmental Management, V7, P75 CELIK O, 1998, AURIS NASUS LARYNX, V25, P364 Chen JD, 2003, ARCH ENVIRON HEALTH, V58, P55, DOI 10.3200/AEOH.58.1.55-58 CHUNG DY, 1983, AUDIOLOGY, V22, P199 Clark WW, 1999, JAMA-J AM MED ASSOC, V281, P1658, DOI 10.1001/jama.281.17.1658 Cruickshanks KJ, 2003, ARCH OTOLARYNGOL, V129, P1041, DOI 10.1001/archotol.129.10.1041 Daniell WE, 2006, OCCUP ENVIRON MED, V63, P343, DOI 10.1136/oem.2005.024588 DOBIE RA, 1998, HEAD NECK SURG OTOLA, V2, P2153 FITZGERALD O, 1997, SCOTT BROWNS OTOLARY García A M, 1992, Acta Otorrinolaringol Esp, V43, P199 GOODHILL V, 1979, EAR DIS DEAFNESS DIZ, P521 GOSZTONYI RE, 1975, J OCCUP ENVIRON MED, V17, P569 HETU R, 1995, OCCUP MED, V10, P495 Jerger J, 1993, J Am Acad Audiol, V4, P42 KOWALSKA S, 1997, INT OCCUP MED ENV HL, V10, P41 Lusk S L, 1997, AAOHN J, V45, P397 Lusk SL, 2002, NURS CLIN N AM, V37, P257, DOI 10.1016/S0029-6465(01)00005-6 MANTYSALO S, 1984, BRIT J IND MED, V41, P122 May JJ, 2000, AM J IND MED, V37, P112, DOI 10.1002/(SICI)1097-0274(200001)37:1<112::AID-AJIM9>3.0.CO;2-# McBride DI, 2001, OCCUP ENVIRON MED, V58, P46, DOI 10.1136/oem.58.1.46 MCSHANE DP, 1988, CLIN OTOLARYNGOL, V13, P323, DOI 10.1111/j.1365-2273.1988.tb00760.x MORATA TC, 1993, SCAND J WORK ENV HEA, V19, P245 ODUSANYA OO, 2004, NIGER J CLIN PRACT, V7, P4 Ologe FE, 2006, EUR ARCH OTO-RHINO-L, V263, P618, DOI 10.1007/s00405-006-0043-9 Ologe FE, 2005, INT J PEDIATR OTORHI, V69, P387, DOI 10.1016/j.ijporl.2004.11.009 Ologe FE, 2005, OCCUP MED-OXFORD, V55, P487, DOI 10.1093/occmed/kqi089 Ologe F. E., 2005, Noise & Vibration Worldwide, V36, DOI 10.1260/0957456053499077 Osibogun A, 2000, Niger Postgrad Med J, V7, P104 PEARSON JD, 1995, J ACOUST SOC AM, V97, P1196, DOI 10.1121/1.412231 PHOON WH, 1993, OCCUP MED-OXFORD, V43, P35, DOI 10.1093/occmed/43.1.35 RAMAZZINI B, 1831, DIS WORKERS, P438 Shakhatreh FM, 2000, SAUDI MED J, V21, P58 Sliwinska-Kowalska M., 1997, Medycyna Pracy, V48, P613 STEVENS JC, 1997, SCOTT BROWNS OTOLARY SULKOWSKI W, 1986, Medycyna Pracy, V37, P175 THIERY L, 1982, SOZ PRAVENTIV MED, V27, P85, DOI 10.1007/BF02075569 Wong TW, 2003, OCCUP ENVIRON MED, V60, P667, DOI 10.1136/oem.60.9.667 2006, NOISE INDUCED HEARIN NR 41 TC 4 Z9 4 PU CAMBRIDGE UNIV PRESS PI CAMBRIDGE PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND SN 0022-2151 J9 J LARYNGOL OTOL JI J. Laryngol. Otol. PD AUG PY 2008 VL 122 IS 8 BP 786 EP 794 DI 10.1017/S0022215107000242 PG 9 WC Otorhinolaryngology SC Otorhinolaryngology GA 336QP UT WOS:000258380000004 PM 17666128 ER PT J AU Liu, JK Mahaney, K Barnwell, SL McMenomey, SO Delashaw, JB AF Liu, James K. Mahaney, Kelly Barnwell, Stanley L. McMenomey, Sean O. Delashaw, Johnny B., Jr. TI Dural arteriovenous fistula of the anterior condylar confluence and hypoglossal canal mimicking a jugular foramen tumor - Case report SO JOURNAL OF NEUROSURGERY LA English DT Article DE anterior condylar confluence; dural arteriovenous fistula; hypoglossal canal; jugular foramen tumor ID VENOUS DRAINAGE; SINUS; VEIN AB The anterior condylar confluence (ACC) is located on the external orifice of the canal of the hypoglossal nerve and provides multiple connections with the dural venous sinuses of the posterior fossa, internal jugular vein, and the vertebral venous plexus. Dural arteriovenous fistulas (DAVFs) of the ACC and hypoglossal canal (anterior condylar vein) are extremely rare. The authors present a case involving an ACC DAVF and hypoglossal canal that mimicked a hypervascular jugular bulb tumor. This 53-year-old man presented with right hypoglossal nerve palsy. A right pulsatile tinnitus had resolved several months previously. Magnetic resonance imaging demonstrated an enhancing right-sided jugular foramen lesion involving the hypoglossal canal. Cerebral angiography revealed a hypervascular lesion at the jugular bulb, with early venous drainage into the extracranial vertebral venous plexus. This was thought to represent either a glomus jugulare tumor or a DAVF. The patient underwent preoperative transarterial embolization followed by surgical exploration via a far-lateral transcondylar approach. At surgery, a DAVF was identified draining into the ACC and hypoglossal canal. The fistula was surgically obliterated, and this was confirmed on postoperative angiography. The patient's hypoglossal nerve palsy resolved. Dural arteriovenous fistulas of the ACC and hypoglossal canal are rare lesions that can present with isolated hypoglossal nerve palsies. They should be included in the differential diagnosis of hypervascular jugular bulb lesions. The authors review the anatomy of the ACC and discuss the literature on DAVFs involving the hypoglossal canal. C1 [Liu, James K.; Barnwell, Stanley L.; McMenomey, Sean O.; Delashaw, Johnny B., Jr.] Oregon Hlth & Sci Univ, Dept Neurol Surg, Portland, OR 97239 USA. [McMenomey, Sean O.; Delashaw, Johnny B., Jr.] Oregon Hlth & Sci Univ, Dept Otolaryngol Head & Neck Surg, Portland, OR 97239 USA. [Mahaney, Kelly] Oregon Hlth & Sci Univ, Sch Med, Portland, OR 97239 USA. [Barnwell, Stanley L.] Oregon Hlth & Sci Univ, Dotter Intervent Inst, Portland, OR 97239 USA. [Liu, James K.] Northwestern Univ, Dept Neurol Surg, Feinberg Sch Med, Evanston, IL USA. RP Delashaw, JB (reprint author), Oregon Hlth & Sci Univ, Dept Neurol Surg, Mail Code CH8N,3303 SW Bond Ave, Portland, OR 97239 USA. EM delashaw@ohsu.edu CR Arnautovic KI, 1997, J NEUROSURG, V86, P252, DOI 10.3171/jns.1997.86.2.0252 Blomquist MH, 1998, AM J NEURORADIOL, V19, P951 Ernst R, 1999, AM J NEURORADIOL, V20, P2016 Katsuta T, 1997, NEUROSURGERY, V41, P149, DOI 10.1097/00006123-199707000-00030 Kiyosue H, 2001, J NEUROSURG, V94, P630, DOI 10.3171/jns.2001.94.4.0630 MALIK GM, 1994, J NEUROSURG, V81, P620, DOI 10.3171/jns.1994.81.4.0620 McDougall CG, 1997, AM J NEURORADIOL, V18, P1565 PIEROT L, 1992, AM J NEURORADIOL, V13, P315 PISKE RL, 1988, NEURORADIOLOGY, V30, P426 Ruiz DS, 2002, AM J NEURORADIOL, V23, P1500 Tanoue S, 2005, AM J NEURORADIOL, V26, P1955 NR 11 TC 7 Z9 8 PU AMER ASSOC NEUROLOGICAL SURGEONS PI ROLLING MEADOWS PA 5550 MEADOWBROOK DRIVE, ROLLING MEADOWS, IL 60008 USA SN 0022-3085 J9 J NEUROSURG JI J. Neurosurg. PD AUG PY 2008 VL 109 IS 2 BP 335 EP 340 DI 10.3171/JNS/2008/109/8/0335 PG 6 WC Clinical Neurology; Surgery SC Neurosciences & Neurology; Surgery GA 330QR UT WOS:000257958400027 PM 18671650 ER PT J AU Celli, A Ribas, A Zannin, PHT AF Celli, Ariani Ribas, Angela Trombetta Zannin, Paulo Henrique TI Effect of impulsive noise on military personnel - A case study SO JOURNAL OF SCIENTIFIC & INDUSTRIAL RESEARCH LA English DT Article DE acoustic measurements; gunshot; impulsive noise; noise-induced hearing loss; temporary threshold shift ID EXPOSURE AB Present study measures effects of impulsive noise level and assesses audiologically occurrence of noise-induced hearing loss or temporary threshold shift (TTS) during gunshot practice by military men. No significant variation in hearing threshold in any frequency before and after gunshot practice was observed, thus no TTS was detected. Alterations in hearing thresholds at 6 kHz and 8 kHz were observed in individuals who already presented cochlear hearing loss. Individuals reported following effects: tinnitus, 21; dizziness, 13; discomfort under loud sounds, 26; and difficulties in speech comprehension, 26%. C1 Univ Fed Parana, LAAICA Lab Acust Ambiental Ind & Conforto Acust, BR-80060000 Curitiba, Parana, Brazil. RP Celli, A (reprint author), Univ Fed Parana, LAAICA Lab Acust Ambiental Ind & Conforto Acust, BR-80060000 Curitiba, Parana, Brazil. EM paulo.zannin@pesquisador.cnpq.br CR COX HJ, 1995, J LARYNGOL OTOL, V109, P291 Kerry G, 1996, APPL ACOUST, V47, P331, DOI 10.1016/0003-682X(95)00039-C Kruger EL, 2004, BUILD ENVIRON, V39, P1055, DOI 10.1016/j.buildenv.2004.01.030 Mrena R, 2002, AUDIOL NEURO-OTOL, V7, P122, DOI 10.1159/000057660 SATALOFF RT, 1993, OCCUPATIONAL HEARING, P797 Sharma O, 1999, APPL ACOUST, V58, P443, DOI 10.1016/S0003-682X(99)00010-9 Silva Ana P., 2004, Rev. Bras. Otorrinolaringol., V70, P344, DOI 10.1590/S0034-72992004000300010 Smeatham D, 1998, APPL ACOUST, V54, P165, DOI 10.1016/S0003-682X(96)00026-6 Stewart Michael, 2002, J Am Acad Audiol, V13, P160 YAMAMURA K, 1980, EUR J APPL PHYSIOL O, V43, P135, DOI 10.1007/BF00422444 Zannin PHT, 2006, ENVIRON MONIT ASSESS, V118, P423, DOI 10.1007/s10661-006-1506-6 Zannin PHT, 2008, INT J IND ERGONOM, V38, P232, DOI 10.1016/j.ergon.2006.06.014 NR 12 TC 1 Z9 1 PU NATL INST SCIENCE COMMUNICATION-NISCAIR PI NEW DELHI PA DR K S KRISHNAN MARG, PUSA CAMPUS, NEW DELHI 110 012, INDIA SN 0022-4456 J9 J SCI IND RES INDIA JI J. Sci. Ind. Res. PD AUG PY 2008 VL 67 IS 8 BP 605 EP 608 PG 4 WC Engineering, Multidisciplinary SC Engineering GA 337UE UT WOS:000258460200006 ER PT J AU Heffner, HE Koay, G Heffner, RS AF Heffner, Henry E. Koay, Gimseong Heffner, Rickye S. TI Comparison of behavioral and auditory brainstem response measures of threshold shift in rats exposed to loud sound SO JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA LA English DT Article ID HEARING THRESHOLDS; TINNITUS AB The purpose of this study was to determine how closely the auditory brainstem response (ABR) can estimate sensorineural threshold shifts in rats exposed to loud sound. Behavioral and ABR thresholds were obtained for tones or noise before and after exposure to loud sound. The results showed that the ABR threshold shift obtained with tone pips estimated the initial pure-tone threshold shifts to within +/- 5 dB 11% of the time and the permanent pure-tone threshold shifts 55% of the time, both with large errors. Determining behavioral thresholds for the same tone pips used for the ABR did not improve the agreement between the measures. In contrast, the ABR obtained with octave noise estimated the initial threshold shifts for that noise to within +/- 5 dB 25% of the time and the permanent threshold shifts 89% of the time, with much smaller errors. Thus, it appears that the noise-evoked ABR is more accurate in estimating threshold shift than the tone-evoked ABR. (c) 2008 Acoustical Society of America. C1 [Heffner, Henry E.; Koay, Gimseong; Heffner, Rickye S.] Univ Toledo, Dept Psychol, Toledo, OH 43606 USA. RP Heffner, HE (reprint author), Univ Toledo, Dept Psychol, Toledo, OH 43606 USA. EM hheffne@pop3.utoledo.edu CR BORG E, 1983, ACTA OTO-LARYNGOL, V95, P19, DOI 10.3109/00016488309130911 DALLOS P, 1978, J ACOUST SOC AM, V64, P151, DOI 10.1121/1.381980 DAVIS H, 1950, Acta Otolaryngol Suppl, V88, P1 DAVIS RI, 1984, EAR HEARING, V5, P153, DOI 10.1097/00003446-198405000-00006 Finneran JJ, 2006, J ACOUST SOC AM, V119, P3181, DOI 10.1121/1.2180208 Gorga M.P., 2002, SOUND FDN EARLY AMPL, P49 Gorga Michael P., 1999, Seminars in Hearing, V20, P29, DOI 10.1055/s-0028-1089910 Heffner H. E., 2006, CURRENT PROTOCOLS NE Heffner HE, 2005, BEHAV NEUROSCI, V119, P734, DOI 10.1037/0735-7044.119.3.734 Heffner H.E., 2003, HDB RES METHODS EXPT, P413, DOI 10.1002/9780470756973.ch19 HEFFNER HE, 1994, HEARING RES, V73, P244, DOI 10.1016/0378-5955(94)90240-2 Heffner HE, 2002, HEARING RES, V170, P83, DOI 10.1016/S0378-5955(02)00343-X HENDERSON D, 1983, AUDIOLOGY, V22, P172 IMIG T, 2007, ASS RES OT ABSTR, V30, P136 KELLY JB, 1977, J COMP PHYSIOL PSYCH, V91, P930, DOI 10.1037/h0077356 MASTERTO.B, 1969, J ACOUST SOC AM, V45, P966, DOI 10.1121/1.1911574 Stapells D. R., 2000, SOUND FDN EARLY AMPL, P13 Stapells DR, 2000, J SPEECH LANGUAGE PA, V42, P74 Szymanski MD, 1999, J ACOUST SOC AM, V106, P1134, DOI 10.1121/1.427121 ZHANG J, 2004, ASS RES OT ABSTR, V27, P302 NR 20 TC 4 Z9 5 PU ACOUSTICAL SOC AMER AMER INST PHYSICS PI MELVILLE PA STE 1 NO 1, 2 HUNTINGTON QUADRANGLE, MELVILLE, NY 11747-4502 USA SN 0001-4966 J9 J ACOUST SOC AM JI J. Acoust. Soc. Am. PD AUG PY 2008 VL 124 IS 2 BP 1093 EP 1104 DI 10.1121/1.2949518 PG 12 WC Acoustics; Audiology & Speech-Language Pathology SC Acoustics; Audiology & Speech-Language Pathology GA 334OG UT WOS:000258230500048 PM 18681599 ER PT J AU Lasisi, AO Abdullahi, M AF Lasisi, Akeem O. Abdullahi, Mohammed TI The inner ear in patients with nasal allergy SO JOURNAL OF THE NATIONAL MEDICAL ASSOCIATION LA English DT Article DE ears; nose; allergy; prevalence ID HUMAN ENDOLYMPHATIC SAC; MENIERES-DISEASE AB Background: The endolymphatic sac has been proposed as a target organ responsible for inner-ear symptom in allergic subjects. This is a report of inner-ear symptoms in patients with nasal allergy. Method: Retrospective review of record charts of patients with known nasal allergy presenting to the otorhinolaryngology out-patient department of the University College Hospital, Ibadan in 5 years. Result: Ear symptoms were found in 95/144 (66%) subjects with nasal allergy. This comprises of 41 males and 44 females (M: F=1:1). Of these, itching of the external ear canal, hearing loss and tinnitus accounted for 63 (66%), 55 (58%) and 39 (41%), respectively, while vertigo was found in 12 (13%). Peripheral vestibular signs of imbalance were seen in 11/95. The audiological assessment of 73 subjects revealed normal pure-tone average in 43 (59%), and sensorineural hearing loss (SHL) in 17 (23.3%). The severity of SHL was mild in 6/17, moderate in 7 and moderate-to-severe in 4. The erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) were elevated in 10/15 (67%) and 6/15 (40%), while the skin sensitivity test showed reactions to dust in 32, cold in 25, cockroach in 7, perfume in 11, vegetable oil in 1 and insecticide in 2. The clinical diagnoses were idiopathic tinnitus in 25 (26.3%), Idiopathic SHL in 17 (18%), cochlear hydrop in 6 (6%) and autoimmune inner-ear disease in 6 (6%). Conclusion: This report suggests some peculiar predisposition to inner-ear pathology in patients with nasal allergy. However a longitudinal assessment of cochleovestibular features of nasal allergy subjects will help in its validation. C1 [Lasisi, Akeem O.] Univ Ibadan, Dept Otorhinolaryngol, Coll Med, Ibadan 234, Nigeria. [Abdullahi, Mohammed] Univ Coll Ibadan Hosp, Dept Otorhinolaryngol, Ibadan, Oyo State, Nigeria. RP Lasisi, AO (reprint author), Univ Ibadan, Dept Otorhinolaryngol, Coll Med, POB 22040, Ibadan 234, Nigeria. EM akeemlasisi@gmail.com CR ALTERMATT HJ, 1990, ORL J OTO-RHINO-LARY, V52, P143 Boulassel MR, 2001, ACTA OTO-LARYNGOL, V121, P28 DEREBERY MJ, 1995, P 5 INT TINN SEM POR, P477 Derebery MJ, 2000, OTOLARYNG HEAD NECK, V122, P174, DOI 10.1016/S0194-5998(00)70235-X Derebery MJ, 2000, OTOLARYNG HEAD NECK, V123, P69, DOI 10.1067/mhn.2000.105715 Derebery MJ, 2003, OTOLARYNG CLIN N AM, V36, P989, DOI 10.1016/S0030-6665(03)00055-0 DEREBERY MJ, 1992, OTOLARYNG CLIN N AM, V25, P213 Duke WW, 1923, J AMER MED ASSOC, V81, P2179 GADRE AK, 1993, OTOLARYNG HEAD NECK, V108, P141 GIBBS SR, 1999, OTOLARYNGOL HEAD NEC, V12, P283 HARRIS JP, 1987, LARYNGOSCOPE, V97, P63 Ruckenstein MJ, 1999, AM J OTOLARYNG, V20, P161, DOI 10.1016/S0196-0709(99)90064-9 Sen P, 2005, J LARYNGOL OTOL, V119, P455 UNO K, 1992, ANN OTO RHINOL LARYN, V101, pS78 WACKYM PA, 1987, ANN OTO RHINOL LARYN, V96, P276 NR 15 TC 6 Z9 7 PU NATL MED ASSOC PI WASHINGON PA 1012 10TH ST, N W, WASHINGON, DC 20001 USA SN 0027-9684 J9 J NATL MED ASSOC JI J. Natl. Med. Assoc. PD AUG PY 2008 VL 100 IS 8 BP 903 EP 905 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA 338CM UT WOS:000258482600004 PM 18717140 ER PT J AU Brocks, C Bela, C Gaebel, C Wollenberg, B Sommer, K AF Brocks, C. Bela, C. Gaebel, C. Wollenberg, B. Sommer, K. TI A dural fistula as a rare cause for a pulse-synchronized tinnitus aurium - A casereport with overview of the literature SO LARYNGO-RHINO-OTOLOGIE LA German DT Article DE arteriovenous fistulas; pulse-synchronized tinnitus aurium; MRI-angiography; Cognard's classification ID CEREBRAL ARTERIOVENOUS-MALFORMATIONS; INTRACRANIAL HEMORRHAGE; CLASSIFICATION; EXPERIENCE; MANAGEMENT; DIAGNOSIS; ANOMALIES; DRAINAGE; NECK; HEAD AB Pulse-synchronized tinnitus aurium is commonly caused by vascular processes within the area of the temporal bone. With a microphone or a stethoscope in the external ear or on the mastoid perceptible noises can be heard by the physican. The most important differential diagnoses of an objective tinnitus are paraganglioma of the glomus jugulare or the glomus tympanicum, vascular stenosis, arteriovenouse malformations, aneurysms and atypic findings of the bulbus venae jugularis interna of the temporal bone. In case of a pulse-synchronized tinnitus purposeful use of neuroradiological diagnostic can lead to a correct diagnosis. The indication for invasive intervention of dural fistulas depends on the number and the hemodynamic relevance of these fistulas and on individual suffering of the patient. Even if it does not succeed, all to embolize AV-short-circuits, it is possible to reduce the intensity of the tinnitus in order to continue with conservative therapy. C1 [Brocks, C.; Wollenberg, B.] Univ Klinikum Schleswig Holstein, Klin Hals Nasen & Ohrenheilkunde, D-23538 Lubeck, Germany. [Bela, C.] Asklepios Klin St Georg, HNO Abt, Hamburg, Germany. [Gaebel, C.] Univ Klinikum Schleswig Holstein, Klin Neuroradiol, D-23538 Lubeck, Germany. [Sommer, K.] Asklepios Klin Hamburg Nord, HNO Abt Plast Kopf & Halschirurg, Hamburg, Germany. RP Brocks, C (reprint author), Univ Klinikum Schleswig Holstein, Klin Hals Nasen & Ohrenheilkunde, Campus Lubeck,Ratzeburger Allee 160, D-23538 Lubeck, Germany. 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PD AUG PY 2008 VL 87 IS 8 BP 573 EP 578 DI 10.1055/s-2007-995600 PG 6 WC Otorhinolaryngology SC Otorhinolaryngology GA 337TL UT WOS:000258458300013 PM 18535939 ER PT J AU Bektas, D Caylan, R AF Bektas, Devrim Caylan, Refik TI Non-pulsatile subjective tinnitus without hearing loss may be caused by undetectable sounds originating from venous system of the brain SO MEDICAL HYPOTHESES LA English DT Article ID DYNAMICS; MRI AB Tinnitus is a common otologic symptom, which can interfere with the daily activities of life. Subjective tinnitus is perception of sound only heard by the patient. The most common type of tinnitus is non-pulsatile subjective tinnitus (NST), which is believed to originate from auditory pathway, mostly from central nervous system. This hypothesis proposes that an important percentage of NST cases are actually misdiagnosed venous type tinnitus cases. Recent studies have demonstrated that dural-jugular system is dominant only in the horizontal body position. Jugular flow is at maximum during this position possibly making any noise generated within the dural-jugular system louder. As body assumes more vertical positions it gradually leaves its function to the extrajugular venous system of the brain. When there is an objective and/or a pulsating sound it is easier to suspect a vascular etiology and diagnose it clinically or radiologically. However, if a vascular pathology causes a non-pulsatite complaint that can not be heard by the examiner or can not be detected clinically or radiologically, it is bound to be misdiagnosed as central tinnitus. Most NST cases experience their symptoms especially at night. Night time usually allows the combination of silent ambience and horizontal body position to take place. We believe that in some NST cases, especially those without hearing loss (HL), the main cause of tinnitus is venous in origin. (C) 2008 Elsevier Ltd. All rights reserved. C1 [Bektas, Devrim; Caylan, Refik] KBB Anabilim Dali, KTU Med Fac, Dept Otolaryngol, Trabzon, Turkey. RP Bektas, D (reprint author), KBB Anabilim Dali, KTU Med Fac, Dept Otolaryngol, Trabzon, Turkey. 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Hypotheses PD AUG PY 2008 VL 71 IS 2 BP 245 EP 248 DI 10.1016/j.mehy.2008.03.024 PG 4 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA 331LN UT WOS:000258013800014 PM 18472353 ER PT J AU Kapoor, KG AF Kapoor, Kapil. G. TI Etiology of dizziness, tinnitus, and nausea in idiopathic intracranial hypertension SO MEDICAL HYPOTHESES LA English DT Letter RP Kapoor, KG (reprint author), 9420 Seawall Blvd,Unit 304, Galveston, TX 77554 USA. EM kaps2003@gmail.com CR DeJonckere P H, 2001, Int Tinnitus J, V7, P59 Friedman DI, 2004, NEUROL CLIN, V22, P99, DOI 10.1016/S0733-8619(03)00096-3 KAPOOR KG, MED HYPOTHE IN PRESS Moller AR, 2007, PROG BRAIN RES, V166, P37, DOI 10.1016/S0079-6123(07)66003-8 MOLLER M B, 1991, Keio Journal of Medicine, V40, P146 NR 5 TC 2 Z9 2 PU CHURCHILL LIVINGSTONE PI EDINBURGH PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE, LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND SN 0306-9877 J9 MED HYPOTHESES JI Med. Hypotheses PD AUG PY 2008 VL 71 IS 2 BP 310 EP 311 DI 10.1016/j.mehy.2008.03.018 PG 2 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA 331LN UT WOS:000258013800033 PM 18448266 ER PT J AU Plotkin, SR Singh, MA O'Donnell, CC Harris, GJ McClatchey, AI Halpin, C AF Plotkin, Scott R. Singh, Marybeth A. O'Donnell, Caroline C. Harris, Gordon J. McClatchey, Andrea I. Halpin, Chris TI Audiologic and radiographic response of NF2-related vestibular schwannoma to erlotinib therapy SO NATURE CLINICAL PRACTICE ONCOLOGY LA English DT Article DE erlotinib; neurofibromatosis; schwannoma; vestibular ID STEREOTACTIC RADIOSURGERY; NEUROFIBROMATOSIS-2; MANAGEMENT; DISEASE; UPDATE; TUMORS; TYPE-2 AB Background A 48-year-old man presented to a neurologist with complaints of bilateral hearing loss and tinnitus. The patient was a member of a large family affected by neurofibromatosis type 2 and first noted hearing loss 10 years before presentation. Investigations Medical and neurological examination, MRI scan of the brain and spinal cord, pure-tone audiometry, NU-6 monosyllabic word test with phoneme scoring, City University of New York topic-related sentences test, noise/voice test of minimal auditory capability battery. Diagnosis Progressive neurofibromatosis-type-2-related vestibular schwannomas. Management Annual cranial MRI and audiology, surgical resection of right vestibular schwannoma, high-power behind-the-ear hearing aid, erlotinib therapy for progressive left vestibular schwannoma. C1 [Plotkin, Scott R.] Massachusetts Gen Hosp, Dept Neurol, Neurofibromatosis Clin, Boston, MA 02114 USA. [Harris, Gordon J.] Harvard Univ, Sch Med, Cambridge, MA 02138 USA. [Harris, Gordon J.] Massachusetts Gen Hosp, Imaging Serv 3D, Boston, MA 02114 USA. [McClatchey, Andrea I.] Massachusetts Eye & Ear Infirm, Dept Audiol, Boston, MA 02114 USA. RP Plotkin, SR (reprint author), Massachusetts Gen Hosp, Dept Neurol, Neurofibromatosis Clin, 55 Fruit St,yawkey 9E, Boston, MA 02114 USA. EM splotkin@partners.org CR *AM NAT STAND I, 2004, S321 ANSI Baser ME, 2002, NEUROLOGY, V59, P1759 BOOTHROYD A, 1981, HEARING MEASUREMENT, P134 BOOTHROYD A, 1988, EAR HEARING, V9, P306 Curto M, 2007, J CELL BIOL, V177, P893, DOI 10.1083/jcb.200703010 Evans DGR, 2006, J MED GENET, V43, P289, DOI 10.1136/jmg.2005.036319 Evans DGR, 2005, BRIT J NEUROSURG, V19, P5, DOI 10.1080/02688690500081206 Evans DGR, 2005, OTOL NEUROTOL, V26, P93, DOI 10.1097/00129492-200501000-00016 Farrell CJ, 2007, NEUROL CLIN, V25, P925, DOI 10.1016/j.ncl.2007.07.008 HALPIN C, EVIDENCE BA IN PRESS, P227 Mathieu D, 2007, NEUROSURGERY, V60, P460, DOI 10.1227/01.NEU.0000255340.26027.53 MULVIHILL JJ, 1990, ANN INTERN MED, V113, P39 NIH Consensus Development Conference Statement, 1988, ARCH NEUROL-CHICAGO, V45, P575 Otto SR, 2002, J NEUROSURG, V96, P1063, DOI 10.3171/jns.2002.96.6.1063 OWENS E, 1982, ARCH OTOLARYNGOL, V108, P478 Rowe JG, 2003, J NEUROL NEUROSUR PS, V74, P1288, DOI 10.1136/jnnp.74.9.1288 Shepherd FA, 2005, NEW ENGL J MED, V353, P123, DOI 10.1056/NEJMoa050753 Sorensen AG, 2001, J CLIN ONCOL, V19, P551 NR 18 TC 28 Z9 28 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK STREET, 9TH FLOOR, NEW YORK, NY 10013-1917 USA SN 1743-4254 J9 NAT CLIN PRACT ONCOL JI Nat. Clin. Pract. Oncol. PD AUG PY 2008 VL 5 IS 8 BP 487 EP 491 DI 10.1038/ncponc1157 PG 5 WC Oncology SC Oncology GA 332IQ UT WOS:000258077100011 PM 18560388 ER PT J AU Landgrebe, M Nyuyki, K Frank, E Steffens, T Hauser, S Eichhammer, P Hajak, G Langguth, B AF Landgrebe, Michael Nyuyki, Kewir Frank, Elmar Steffens, Thomas Hauser, Simone Eichhammer, Peter Hajak, Goeran Langguth, Berthold TI Effects of colour exposure on auditory and somatosensory perception - hints for cross-modal plasticity SO NEUROENDOCRINOLOGY LETTERS LA English DT Article DE colour stimulation; auditory perception; somatosensory perception; cross-modal plasticity; pain thresholds ID STIMULATION; PERFORMANCE; EMOTIONS AB OBJECTIVES: It is well known that colour exposure can influence emotions, behaviour and perception. To get further insight into these complex synesthetic phenomena, the effect of colour stimulation on auditory and somatosensory perception was systematically investigated. METHODS: 14 healthy male volunteers with normal colour vision rated the loudness of auditory stimuli with a standardized scale during exposure to white, red and green light. Furthermore temperature perception was assessed during exposure of the different colours using a thermal sensory analyser. RESULTS: Colour exposure significantly altered auditory and somatosensory perception. Red light enhanced loudness perception and decreased cold pain thresholds, while green light stimulation reduced loudness perception and increased detection and pain thresholds for warm stimuli. CONCLUSIONS: This data give further evidence for cross-modal plasticity in human perception. Colour stimulation influences auditory and somatosensory perception and may therefore have potential as a new treatment strategy of phantom perceptions such as tinnitus or chronic pain. C1 [Landgrebe, Michael; Nyuyki, Kewir; Frank, Elmar; Hauser, Simone; Eichhammer, Peter; Hajak, Goeran; Langguth, Berthold] Univ Regensburg, Dept Psychiat Psychosomat & Psychotherapy, D-93053 Regensburg, Germany. [Steffens, Thomas] Univ Regensburg, Univ Hosp Regensburg, Dept Otorhinolaryngol, D-93053 Regensburg, Germany. RP Landgrebe, M (reprint author), Univ Regensburg, Dept Psychiat Psychosomat & Psychotherapy, Univ Str 84, D-93053 Regensburg, Germany. EM michael.landgrebe@medbo.de CR Abe K., 1999, INTERNOISE, V99, P1177 Gilbert AN, 1996, AM J PSYCHOL, V109, P335, DOI 10.2307/1423010 Hatta T, 2002, PERCEPT MOTOR SKILL, V94, P39, DOI 10.2466/PMS.94.1.39-46 Imhof M, 2004, EUR CHILD ADOLES PSY, V13, P191, DOI 10.1007/s00787-004-0371-5 Lockwood AH, 1999, CEREB CORTEX, V9, P65, DOI 10.1093/cercor/9.1.65 Mendlewicz J, 1976, Acta Psychiatr Belg, V76, P301 Pause BM, 2003, PSYCHOPHYSIOLOGY, V40, P209, DOI 10.1111/1469-8986.00023 Shams L, 2002, COGNITIVE BRAIN RES, V14, P147, DOI 10.1016/S0926-6410(02)00069-1 Summers J, 2004, NEUROSCI LETT, V368, P197, DOI 10.1016/j.neulet.2004.07.008 VALDEZ P, 1994, J EXP PSYCHOL GEN, V123, P394, DOI 10.1037/0096-3445.123.4.394 Wilkins AJ, 1999, SEIZURE-EUR J EPILEP, V8, P444, DOI 10.1053/seiz.1999.0337 NR 11 TC 3 Z9 3 PU MAGHIRA & MAAS PUBLICATIONS PI STOCKHOLM PA PO BOX 26132, S-100 41 STOCKHOLM, SWEDEN SN 0172-780X J9 NEUROENDOCRINOL LETT JI Neuroendocrinol. Lett. PD AUG PY 2008 VL 29 IS 4 BP 518 EP 521 PG 4 WC Endocrinology & Metabolism; Neurosciences SC Endocrinology & Metabolism; Neurosciences & Neurology GA 356JJ UT WOS:000259774200023 PM 18766155 ER PT J AU Khedr, EM Rothwell, JC Ahmed, MA Awad, EM Galal, O AF Khedr, E. M. Rothwell, J. C. Ahmed, M. A. Awad, E. M. Galal, O. TI Cortical excitability and transcallosal inhibition in chronic tinnitus: Transcranial magnetic study SO NEUROPHYSIOLOGIE CLINIQUE-CLINICAL NEUROPHYSIOLOGY LA English DT Article DE cortical excitability; transcranial magnetic stimulation; chronic tinnitus; transcallosal inhibition ID MOTOR CORTEX; STIMULATION; PLASTICITY; BRAIN AB Introduction. - It has been proposed that tinnitus may be caused by maladaptive plasticity of processing in the central auditory pathways, and that this may be due in part to a generalised deficit in NMDA-dependent glutamatergic synapses. Study aim. - To test this hypothesis, we used transcranial. magnetic stimulation to assess the excitability of a number of well-defined synaptic connections in the motor cortex of patients with tinnitus. Patients and methods. - Thirty-seven patients with chronic tinnitus and 12 normal age- and sex-matched volunteers were used as a control group. We measured resting and active motor thresholds (rMT/aMT) and the duration of the contralateral and ipsilateral cortical silent periods (CSP and ISP). Short interval. intracortical inhibition (SICI) and intracortical facilitation (ICF) were evaluated using a paired pulse stimulation paradigm in the left (dominant) hemisphere. Results. - There was no difference between patients and healthy subjects in rMT or aMT or the onset latency of the ISP. The CSP was shorter in patients (P = 0.046) whereas the ISP was longer than in healthy subjects (P = 0.048) but there was no difference between the hemispheres nor any relation to tinnitus side in patients with predominantly unilateral symptoms. There was no difference in the time course of SICI/ICF between patients and control groups and no significant correlation between tinnitus handicap inventory (THI) score and any of the measures of cortical excitability. Conclusions. - There are small changes incortical excitability in patients with chronic tinnitus. However, given the number of factors we examined in each individual, such minor changes seem unlikely to be an important factor in development of clinical symptoms. (C) 2008 Elsevier Masson SAS. All rights reserved. C1 [Khedr, E. M.] Assiut Univ Hosp, Dept Neurol, Assiut, Egypt. [Awad, E. M.; Galal, O.] Assiut Univ Hosp, Dept Med Physiol, Assiut, Egypt. [Rothwell, J. C.; Ahmed, M. A.] UCL Natl Hosp Neurol & Neurosurg, Sobell Res Dept Motor Neurosci & Movement Disorde, London WC1N 3BG, England. RP Khedr, EM (reprint author), Assiut Univ Hosp, Dept Neurol, Assiut, Egypt. 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Clin.-Clin. Neurophysiol. PD AUG PY 2008 VL 38 IS 4 BP 243 EP 248 DI 10.1016/j.neucli.2008.03.004 PG 6 WC Clinical Neurology; Neurosciences; Physiology SC Neurosciences & Neurology; Physiology GA 340VX UT WOS:000258674200006 PM 18662621 ER PT J AU Manabe, S Satoh, K Matsubara, S Satomi, J Hanaoka, M Nagahiro, S AF Manabe, Shinji Satoh, Koichi Matsubara, Shunji Satomi, Junichiro Hanaoka, Mami Nagahiro, Shinji TI Characteristics, diagnosis and treatment of hypoglossal canal dural arteriovenous fistula: report of nine cases SO NEURORADIOLOGY LA English DT Article DE dural arteriovenous fistula; hypoglossal canal; anterior condylar vein; magic wand appearance ID INFERIOR PETROSAL SINUS; ANTERIOR CONDYLAR VEIN; OF-THE-LITERATURE; VENOUS DRAINAGE; TRANSARTERIAL EMBOLIZATION; TRANSVENOUS EMBOLIZATION; SIGMOID SINUSES; POSTERIOR-FOSSA; RADIOSURGERY; MANAGEMENT AB Introduction We report the characteristics, diagnosis and treatment of dural arteriovenous fistula (DAVF) of the hypoglossal canal in nine patients with this relatively rare vascular disorder. Methods Of 248 patients with intracranial DAVFs managed at our institution, nine patients (3.6%; four men, five women; mean age 62 years) were diagnosed with hypoglossal canal DAVF. We investigated patient characteristics with respect to clinical symptoms, neuroradiological findings, efficacy and complications related to endovascular treatment. Results Seven patients had experienced head injury. All patients presented with pulsatile tinnitus. One patient displayed ipsilateral hypoglossal nerve palsy before treatment. MR angiography showed a "magic wand" appearance between the affected hypoglossal canal and the internal jugular vein in four patients. Angiography demonstrated an AV fistula on the medial aspect of the superior jugular bulb, mostly arising from the bilateral occipital, ascending pharyngeal and vertebral arteries with drainage to the internal jugular vein via the anterior condylar vein. Contralateral carotid injection accurately clarified the shunting point. Five patients underwent endovascular treatment: transarterial embolization (TAE; n= 2), transvenous embolization (TVE; n= 2), and TAE/TVE (n= 1). Complete shunt obliteration was achieved in four patients and shunt reduction in one. The remaining four patients were treated conservatively and the shunt had disappeared at follow-up. Postoperative hypoglossal nerve palsy occurred in one patient after TVE, possibly due to coil overpacking. Conclusion The incidence of hypoglossal canal DAVF was not very low in our series. Contralateral carotid injection is an essential examination to provide an accurate diagnosis. TVE should be considered when access is available, although TAE is also appropriate for shunt reduction. C1 [Manabe, Shinji; Satoh, Koichi; Matsubara, Shunji; Satomi, Junichiro; Hanaoka, Mami; Nagahiro, Shinji] Univ Tokushima, Dept Neurosurg, Tokushima 770, Japan. RP Manabe, S (reprint author), Univ Tokushima, Dept Neurosurg, Tokushima 770, Japan. 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Chinnici, Jill E. Niparko, John K. Francis, Howard W. TI Revision cochlear implantation surgery in adults: Indications and results SO OTOLOGY & NEUROTOLOGY LA English DT Article DE cochlear implant; device defect; electrode extrusion; facial stimulation; hard failure; infection; revision surgery; speech perception; soft failure ID SCALA TYMPANI ELECTRODE; INSERTION DEPTH; REIMPLANTATION; PERFORMANCE; FAILURES; MULTICENTER AB Objective: To assess the efficacy, risks, and indications of revision cochlear implantation (RCI) and to identify the clinical, audiologic, and device-related characteristics that predict outcome. Study Design: Retrospective case series. Setting: Academic tertiary referral center. Patients: Adults (>= 18 yr) who underwent RCI at Johns Hopkins University. Intervention: Revision cochlear implant surgery. Main Outcome Measures: Speech perception by open-set testing and patient report and patient report of symptom resolution. Results: During the 16-year period of this study, 4.8% of all adults implanted at our center have required 1 or more RCI surgeries. A total of 48 RCIs have been performed. The indications for RCI included infection (12%), electrode extrusion (15%), hard failure (23%), suspected device failure (42%), and isolated facial nerve stimulation (8%). Overall, successful resolution of the implant-related or medical condition was achieved with RCI in 83% of cases. Speech perception was lower in only 1 (2.1%) of 48 cases. Satisfactory preoperative speech recognition was preserved or surpassed in 5 of 6 infection cases and 8 cases with progressive symptoms of tinnitus and facial nerve stimulation. All cases of hard failure regained or surpassed previous peak performance. Improved speech recognition was experienced by 75% of cases with suspected device failure. Of cases in which RCI failed to restore previous functional benefit, there was a significant association with advanced age (>70 yr). Whereas an abnormal integrity test was predictive of favorable outcome after RCI, a negative test was not predictive of outcome. A similar pattern of results was observed with respect to ex vivo device analysis. Conclusion: Revision cochlear implantation can be safely performed to restore lost benefit in appropriately selected cases. When properly performed after medical and audiologic options have been exhausted, RCI rarely compromises previous function and, in most cases, can resolve functional complaints and distracting symptoms. When positive, integrity testing is a useful screen for the presence of a device defect. In cases in which device integrity is uncertain, clinical judgment guided by longitudinal assessment can help determine whether RCI is likely to be beneficial. C1 [Rivas, Alejandro; Marlowe, Andrea L.; Chinnici, Jill E.; Niparko, John K.; Francis, Howard W.] Johns Hopkins Univ, Dept Otolaryngol Head & Neck Surg, Listening Ctr, Baltimore, MD USA. RP Francis, HW (reprint author), 601 N Caroline St,JHOC 6251, Baltimore, MD 21287 USA. 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Neurotol. PD AUG PY 2008 VL 29 IS 5 BP 639 EP 648 PG 10 WC Clinical Neurology; Otorhinolaryngology SC Neurosciences & Neurology; Otorhinolaryngology GA 333ZZ UT WOS:000258193400011 PM 18665030 ER PT J AU Teggi, R Bellini, C Fabiano, B Bussi, M AF Teggi, R. Bellini, C. Fabiano, B. Bussi, M. TI Efficacy of low-level laser therapy in Meniere's disease: A pilot study of 10 patients SO PHOTOMEDICINE AND LASER SURGERY LA English DT Article ID HELIUM-NEON LASER; LOW-POWER LASER; IN-VITRO; TINNITUS; BETAHISTINE; IRRADIATION AB Objective: To assess the efficacy of low-level laser therapy (LLLT) for Meniere's disease (MD). Materials and Methods: Twenty patients with unilateral MD were included in the study; all presented with uncontrolled vertigo. The patients were randomly divided into two groups: group 1 patients received LLLT 20 min a day with a 5-mW soft laser for 6 mo, while group 2 received betahistine 16 mg twice a day for 6 mo. According to American Academy of Otolaryngology-Head and Neck Surgery (AAO-HNS) guidelines, the main outcome for vertigo control was considered to be the number of spells per month in the 6 mo before treatment compared with the same parameter in the 6 mo of therapy. The duration of spells expressed in minutes was also considered. Moreover, a hearing test was performed before and after therapy and results were reported as the pure tone average of 500-, 1000-, 2000-, and 3000-Hz frequencies. All results were valued at baseline, and after 3 and 6 mo of therapy. Results: Compared to baseline, the number and duration of spells were significantly reduced in both groups; statistical significance was detected for the 3-mo control in both groups (p < 0.05 with the multiple pair comparison test). Betahistine seems to have a faster action in spell reduction (p < 0.05 comparing the 3-mo results between the two groups). Audiometric examination did not show a statistically significant difference between the two groups. Conclusions: In our experience, LLLT seems to prevent vertigo spells in MD, although results indicate that it has a slower action than betahistine. Dose-dependent therapeutic effects could explain the last result. In our opinion, increased blood flow in the inner ear is the main mechanism leading to the therapeutic results. C1 [Teggi, R.; Bellini, C.; Fabiano, B.; Bussi, M.] Univ Vita Salute San Raffaele, Hosp San Raffaele, Dept Ear Nose & Throat, IRRCS, I-20132 Milan, Italy. RP Teggi, R (reprint author), Univ Vita Salute San Raffaele, Hosp San Raffaele, Dept Ear Nose & Throat, IRRCS, Via Olgettina 60, I-20132 Milan, Italy. 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Consequently, understanding the mechanisms by which salicylate induces tinnitus is an important issue for the research community. Behavioral testing in rats have shown that tinnitus induced by salicylate or mefenamate (both cyclooxygenase blockers) are mediated by cochlear NMDA receptors. Here we report that the synapses between the sensory inner hair cells and the dendrites of the cochlear spiral ganglion neurons express NMDA receptors. Patch-clamp recordings and two-photon calcium imaging demonstrated that salicylate and arachidonate (a substrate of cyclooxygenase) enabled the calcium flux and the neural excitatory effects of NMDA on cochlear spiral ganglion neurons. Salicylate also increased the arachidonate content of the whole cochlea in vivo. Single-unit recordings of auditory nerve fibers in adult guinea pig confirmed the neural excitatory effect of salicylate and the blockade of this effect by NMDA antagonist. These results suggest that salicylate inhibits cochlear cyclooxygenase, which increased levels of arachidonate. The increased levels of arachidonate then act on NMDA receptors to enable NMDA responses to glutamate that inner hair cells spontaneously release. This new pharmacological profile of salicylate provides a molecular mechanism for the generation of tinnitus at the periphery of the auditory system. C1 [Puel, Jean-Luc] INSERM, Unite Mixte Rech 583, Inst Neurosci, F-34091 Montpellier, France. [Leger, Claude Louis] Lab Nutr Humaine & Atherogenese, F-34967 Montpellier, France. [Ruel, Jerome; Chabbert, Christian; Nouvian, Regis; Bendris, Rim; Eybalin, Michel; Bourien, Jerome; Mersel, Marcel; Puel, Jean-Luc] Univ Montpellier 1, F-34967 Montpellier, France. RP Puel, JL (reprint author), INSERM, Unite Mixte Rech 583, Inst Neurosci, 80 Ave Augustin Fl, F-34091 Montpellier, France. 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Neurosci. PD JUL 16 PY 2008 VL 28 IS 29 BP 7313 EP 7323 DI 10.1523/JNEUROSCI.5335-07.2008 PG 11 WC Neurosciences SC Neurosciences & Neurology GA 326VT UT WOS:000257687900009 PM 18632935 ER PT J AU Langguth, B de Ridder, D Dornhoffer, JL Eichhammer, P Folmer, RL Frank, E Fregni, F Gerloff, C Khedr, E Kleinjung, T Landgrebe, M Lee, S Lefaucheur, JP Londero, A Marcondes, R Moller, AR Pascual-Leone, A Plewnia, C Rossi, S Sanchez, T Sand, P Schlee, W Pysch, D Steffens, T van De Heyning, P Hajak, G AF Langguth, Berthold de Ridder, Dirk Dornhoffer, John L. Eichhammer, Peter Folmer, Robert L. Frank, Elmar Fregni, Felipe Gerloff, Christian Khedr, Eman Kleinjung, Tobias Landgrebe, Michael Lee, Scott Lefaucheur, Jean-Pascal Londero, Alain Marcondes, Renata Moller, Aage R. Pascual-Leone, Alvaro Plewnia, Christian Rossi, Simone Sanchez, Tanit Sand, Philipp Schlee, Winfried Pysch, Dipl Steffens, Thomas van de Heyning, Paul Hajak, Goeran TI Controversy: Does repetitive transcranial magnetic stimulation/transcranial direct current stimulation show efficacy in treating tinnitus patients? SO BRAIN STIMULATION LA English DT Review DE tinnitus; transcranial magnetic stimulation; transcranial direct current stimulation; functional imaging; neuronavigation; neuroplasticity; auditory cortex; neuromodulation ID LEFT TEMPOROPARIETAL CORTEX; SECONDARY AUDITORY-CORTEX; HUMAN MOTOR CORTEX; NEURAL PLASTICITY; DOUBLE-BLIND; INTRACTABLE TINNITUS; PRIMING STIMULATION; BRAIN-STIMULATION; SAFETY; RTMS AB Background Tinnitus affects 10% of the population. its pathophysiology remains incompletely understood, and treatment is elusive. Functional imaging has demonstrated a relationship between the intensity of tinnitus and the degree of reorganization in the auditory cortex. Experimental studies have further shown that tinnitus is associated with synchronized hyperactivity in the auditory cortex. Therefore, targeted modulation of auditory cortex has been proposed as a new therapeutic approach for chronic tinnitus. Methods Repetitive transcranial magnetic stimulation (rTMS) and transcranial direct Current stimulation (tDCS) are noninvasive methods that can modulate cortical activity. These techniques have been applied ill different ways in patients with chronic tinnitus. Single sessions of high-frequency rTMS over the temporal cortex have been successful in reducing the intensity of tinnitus during the time Of Stimulation and could be predictive for treatment outcome of chronic epidural stimulation using implanted electrodes. Results Another approach that uses rTMS as a treatment for tinnitus is application of low-frequency rTMS in repeated sessions, to induce a lasting change of neuronal activity in the auditory cortex beyond the duration of stimulation. Beneficial effects of this treatment have been consistently demonstrated ill several small controlled studies. However, results are characterized by high interindividual variability and only a moderate decrease of the tinnitus. The role of patient-related (for example, hearing loss, tinnitus duration, age) and stimulation-related (for example, stimulation site, stimulation protocols) factors still remains to be elucidated. Conclusions Even in this early stage of investigation, there is a convincing body of evidence that rTMS represents a promising tool for pathophysiological assessment and therapeutic management of tinnitus. Further development of this technique will depend on a more detailed understanding of the neurobiological effects mediating the benefit of TMS on tinnitus perception. Moreover clinical studies with larger sample sizes and longer follow-up periods are needed. (c) 2008 Elsevier Inc. All rights reserved. C1 [Langguth, Berthold; Eichhammer, Peter; Frank, Elmar; Landgrebe, Michael; Sand, Philipp; van de Heyning, Paul] Univ Regensburg, Dept Psychiat, D-93053 Regensburg, Germany. [Langguth, Berthold; Eichhammer, Peter; Frank, Elmar; Landgrebe, Michael; Sand, Philipp; Hajak, Goeran] Univ Regensburg, Dept Psychotherapy, D-93053 Regensburg, Germany. [de Ridder, Dirk; van de Heyning, Paul] Univ Antwerp, BRAI2N, B-2020 Antwerp, Belgium. [de Ridder, Dirk] Univ Antwerp, Dept Neurosurg, B-2020 Antwerp, Belgium. [Dornhoffer, John L.] Univ Arkansas Med Sci, Dept Otolaryngol, Little Rock, AR 72205 USA. [Folmer, Robert L.] VA Med Ctr, Natl Ctr Rehabil Auditory Res, Portland, OR USA. [Fregni, Felipe; Pascual-Leone, Alvaro] Harvard Univ, Beth Israel Deaconess Med Ctr, Dept Neurol, Sch Med,Berenson Allen Ctr Noninvas Brain Stimula, Boston, MA 02215 USA. [Gerloff, Christian] Univ Med Ctr Hamburg Eppendorf, Dept Neurol, Hamburg, Germany. [Khedr, Eman; Steffens, Thomas] Assiut Univ, Fac Med, Dept Neurol, Assiut, Egypt. [Kleinjung, Tobias] Univ Regensburg, Dept Otorhinolaryngol, Regensburg, Germany. [Lee, Scott] Albany Med Coll, Div Otolaryngol Head & Neck Surg, Albany, NY 12208 USA. [Lefaucheur, Jean-Pascal] Hop Henri Mondor, Dept Physiol, F-94010 Creteil, France. [Londero, Alain] European Hosp G Pompidou, Dept ORL, Paris, France. [Marcondes, Renata; Sanchez, Tanit] Univ Sao Paulo, Clin Hosp, Dept Otolaryngol & Psychiat, Sao Paulo, Brazil. [Moller, Aage R.] Univ Texas Dallas, Sch Behav & Brain Sci, Dallas, TX 75230 USA. [Plewnia, Christian] Univ Tubingen Hosp, Dept Psychiat & Psychotherapy, Tubingen, Germany. [Rossi, Simone] Univ Siena, Neurol Sect, Dept Neurosci, I-53100 Siena, Italy. [Pysch, Dipl] Univ Konstanz, Dept Psychol, Constance, Germany. Univ Antwerp, Antwerp, Belgium. [van de Heyning, Paul] Univ Antwerp, Dept ENT & Head & Neck Surg, Antwerp, Belgium. RP Langguth, B (reprint author), Univ Regensburg, Dept Psychiat, Univ Str 84, D-93053 Regensburg, Germany. 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PD JUL PY 2008 VL 1 IS 3 SI SI BP 192 EP 205 DI 10.1016/j.brs.2008.06.003 PG 14 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA 398FA UT WOS:000262716800007 PM 20633385 ER PT J AU Buth, B AF Buth, Britta TI The application of introvision for reduction of stress through tinnitus and improvement of the hearing ability SO GRUPPENDYNAMIK UND ORGANISATIONSBERATUNG LA German DT Article DE tinnitus; empirical study; introvision; selfregulation AB The following article describes the first empirical study of the effectiveness of Introvision as a pedagogical - psychological intervention for tinnitus. Introvision is based on the theory of subjective imperatives and the theory of mental introference. The intention was to ceace dysfunctional automatical selfregulation- strategies. Studies of the past have shown that dysfunctional selfregulation- strategies are a cause of increased subjective strain of tinnitus. The following pilot study, accomplished within a bigger project was conducted with 13 elder persons suffering from light to moderate tinnitus in a six-week-intervention with Introvision. Comparison to a control group without intervention showed a significant reduction of the tinnitus in the introvision group (STI, p <= 0.022). At the same time the audiometrically measured hearing ability of the Introvisiongroup increased significantly compared to the controlgroup (p <= 0.001) while a decrease of the subjective loudness of the tinnitus could be only partially ascertained. C1 Univ Hamburg, Fachbereich Erziehungswissensch, D-20144 Hamburg, Germany. RP Buth, B (reprint author), Univ Hamburg, Fachbereich Erziehungswissensch, Bogenallee 11, D-20144 Hamburg, Germany. 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PD JUL PY 2008 VL 39 IS 2 BP 212 EP 224 DI 10.1007/s11612-008-0020-4 PG 13 WC Psychology, Social SC Psychology GA 339XE UT WOS:000258609800007 ER PT J AU Choi, JC Lee, JS Kang, SY Kang, JH Bae, JM AF Choi, Jay Chol Lee, Jung Seok Kang, Sa-Yoon Kang, Ji-Hoon Bae, Jong-Myon TI Chronic daily headache with analgesics overuse in professional women breath-hold divers SO HEADACHE LA English DT Article DE diver; chronic daily headache; prevalence; medication overuse ID GENERAL-POPULATION; FREQUENT HEADACHE; RISK-FACTORS; FOLLOW-UP; PREVALENCE; MEDICATION AB Objective.-The object of this study is to investigate the prevalence and characteristics of headache in Korean professional women breath-hold divers, including their overuse of analgesics. Background.-Headache is a common problem encountered in clinical practice, and undersea divers exhibit unique causes of headache in addition to other common primary headaches. Many scuba divers are known to use various types of drugs to overcome dive-related symptoms or to enhance their underwater performance. Methods.-The target population of this study was women divers in the northern district of Jeju Island who were registered in the divers' union. Data were collected using telephone interviews with a structured questionnaire. Headache was diagnosed and classified according to criteria of the International Headache Society. Results.-Nine hundred and eleven (80.3%) divers responded to the telephone interview. The prevalence rates of headache were 21.4% for tension-type headache and 9.1% for migraine. One hundred and four divers (11.4%) fulfilled the criteria for chronic daily headache (CDH). Overuse of combination analgesics was reported by 70.7% of divers. Women divers with CDH were significantly older and they complained more of tinnitus and dizziness, and had a greater history of hypertension than divers without headache. Conclusion.-The prevalence of CDH is high in Korean professional women breath-hold divers, with many of them being combination-analgesics overusers. C1 [Choi, Jay Chol; Lee, Jung Seok; Kang, Sa-Yoon; Kang, Ji-Hoon] Cheju Natl Univ Hosp, Dept Neurol, Jeju Si 690716, Jeju Do, South Korea. [Bae, Jong-Myon] Cheju Natl Univ, Dept Prevent Med, Cheju, South Korea. RP Choi, JC (reprint author), Cheju Natl Univ Hosp, Dept Neurol, 154 Samdo 2 Dong, Jeju Si 690716, Jeju Do, South Korea. 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TI Tinnitus - An interdisciplinary therapeutic approach is useful SO HNO LA German DT Editorial Material C1 Charite Univ Med Berlin, HNO Klin & Poliklin, Tinnituszentrum, D-10117 Berlin, Germany. RP Mazurek, B (reprint author), Charite Univ Med Berlin, HNO Klin & Poliklin, Tinnituszentrum, Campus Charite Mitte,Charitepl 1, D-10117 Berlin, Germany. EM birgit.mazurek@charite.de CR Eggermont JJ, 2005, DRUG DISCOV TODAY, V10, P1283, DOI 10.1016/S1359-6446(05)03542-7 JASTREBOFF PJ, 1993, BRIT J AUDIOL, V27, P7, DOI 10.3109/03005369309077884 Moller A. R., 2006, HEARING ANATOMY PHYS, V2 Reisshauer A, 2006, HNO, V54, P125, DOI 10.1007/s00106-005-1349-4 NR 4 TC 1 Z9 1 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0017-6192 J9 HNO JI HNO PD JUL PY 2008 VL 56 IS 7 BP 668 EP 668 DI 10.1007/s00106-008-1773-3 PG 1 WC Otorhinolaryngology SC Otorhinolaryngology GA 321PI UT WOS:000257318600001 PM 18560739 ER PT J AU D'Amelio, R Delb, W AF D'Amelio, R. Delb, W. TI Comorbidity of schizophrenic psychosis and tinnitus - A hitherto neglected theme in research and therapy SO HNO LA German DT Article ID RETRAINING THERAPY; DECOMPENSATION; PREDICTORS; AURIUM C1 [D'Amelio, R.] Univ Saarlandes Kliniken, Neurozentrum, D-66421 Homburg, Germany. [Delb, W.] Univ Saarlandes Kliniken, Klin Hals Nasen & Ohrenheilkunde, D-66421 Homburg, Germany. RP D'Amelio, R (reprint author), Univ Saarlandes Kliniken, Neurozentrum, Geb 90-3, D-66421 Homburg, Germany. EM roberto.d.amelio@uks.eu CR Bauml J, 2008, PSYCHOEDUKATION BEI Biesinger E, 1998, HNO, V46, P157, DOI 10.1007/s001060050215 DAMELIO, 2002, MANUAL TINNITUS RETR, P79 DAMELIO R, 2003, PSYCHOSOZIALE VERSOR, P165 DAMELIO R, 2007, NERVENARZY, V78, P327 D'Amelio R, 2004, HNO, V52, P599, DOI 10.1007/s00106-003-0944-5 Delb W, 2002, HNO, V50, P997, DOI 10.1007/s00106-002-0645-5 DELB W, 1999, P 6 INT TINN SEM, P451 Goebel G, 2005, HNO PRAXIS HEUTE, P137 GOEBEL G, 2006, ACTA OTO-LARYNGOL, V556, P70 Walpurger V, 2003, HEARING RES, V181, P57, DOI 10.1016/S0378-5955(03)00172-2 Hesse G, 2001, HNO, V49, P764, DOI 10.1007/s001060170052 Hiller W, 2006, ARCH OTOLARYNGOL, V132, P1323, DOI 10.1001/archotol.132.12.1323 Hoke ES, 1998, AUDIOL NEURO-OTOL, V3, P300, DOI 10.1159/000013802 Jacobson Gary P, 2003, J Am Acad Audiol, V14, P393 Johns LC, 2002, BRIT J CLIN PSYCHOL, V41, P81, DOI 10.1348/014466502163813 Kroner-Herwig B., 1997, PSYCHOL BEHANDLUNG C Kroner-Herwig B, 2003, J PSYCHOSOM RES, V54, P381, DOI 10.1016/S0022-3999(02)00400-2 Langenbach M, 2002, J PSYCHOSOM RES, V52, P401 Linke R, 2003, LARYNGO RHINO OTOL, V82, P620 Marciano E, 2003, INT J AUDIOL, V42, P4, DOI 10.3109/14992020309056079 Mazurek B, 2006, AUDIOL NEURO-OTOL, V11, P276, DOI 10.1159/000093526 NAM EC, 2005, IT IS NECESSARY DIFF Reeves RR, 2000, SOUTHERN MED J, V93, P1030 Schaaf H, 2003, NERVENARZT, V74, P72, DOI 10.1007/s00115-001-1222-y Schildt A, 2006, HNO, V54, P781, DOI 10.1007/s00106-006-1447-y Schilter B, 2000, HNO, V48, P589, DOI 10.1007/s001060050621 STRAUSS DJ, 2005, P 2 INT IEEE EMBS C, P189 Strauss DJ, 2008, IEEE T NEUR SYS REH, V16, P74, DOI 10.1109/TNSRE.2007.911086 von Osterhausen K, 2001, VERHALTENSTHER VERHA, V22, P39 NR 30 TC 5 Z9 5 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0017-6192 J9 HNO JI HNO PD JUL PY 2008 VL 56 IS 7 BP 670 EP 672 DI 10.1007/s00106-008-1790-2 PG 3 WC Otorhinolaryngology SC Otorhinolaryngology GA 321PI UT WOS:000257318600002 PM 18566784 ER PT J AU Biesinger, E Reisshauer, A Mazurek, B AF Biesinger, E. Reisshauer, A. Mazurek, B. TI The role of the cervical spine and the craniomandibular system in the pathogenesis of tinnitus - Somatosensory tinnitus SO HNO LA German DT Article DE somatosensory tinnitus; interdisciplinary tinnitus treatment; tinnitus treatment concept; cochlear nucleus; cervical spine ID TRIGEMINAL GANGLION STIMULATION; DORSAL COCHLEAR NUCLEUS; GUINEA-PIG; PROJECTIONS AB The causes of tinnitus, vertigo, and hearing disturbances may be pathological processes in the cervical spine and temporomaxillary joint. In these cases, tinnitus is called somatosensory tinnitus (SST). For afferences of the cervical spine, projections of neuronal connections in the cochlear nucleus were found. A reflex-like impact of the cervical spine on the cochlear nucleus can be assumed. The tinnitus treatment concept of the Charite University Hospital in Berlin involves the cooperation of ENT specialists with many other disciplines in an outpatient clinic. A standardized examination protocol has been established, and physical therapy has been integrated into the interdisciplinary tinnitus treatment. For tinnitus-modulating therapy of muscular trigger points, local anesthetics as well as self-massage or treatment by a physiotherapist or osteopath are useful. C1 [Biesinger, E.] HNO Praxis Traunstein, D-83278 Traunstein, Germany. [Reisshauer, A.] Charite Univ Med Berlin, Klin Phys Med & Rehabil, Berlin, Germany. [Mazurek, B.] Charite Univ Med Berlin, HNO Klin & Poliklin, Tinnituszentrum, D-10117 Berlin, Germany. RP Biesinger, E (reprint author), HNO Praxis Traunstein, Maxplatz 5, D-83278 Traunstein, Germany. EM Team@HNO-Traunstein.de; birgit.mazurek@charite.de CR BIESINGER E, 1989, HNO PRAXIS HEUTE, V9, P130 Biesinger E, 1997, MANUELLE MED, V35, P12 Bjorney A, 2007, PROG BRAIN RES, V166, P215, DOI 10.1016/S0079-6123(07)66019-1 Decher H, 1969, ZERVIKALEN SYNDROME Ernst E, 2005, LARYNGO RHINO OTOL, V84, P261 HULSE M, 1998, KRANIO ZERVIKALE UBE ITOH K, 1987, BRAIN RES, V400, P145, DOI 10.1016/0006-8993(87)90662-7 KALTENBACH JA, 2006, ACTA OTO-LARYNGOL, V556, P20 Kraft CN, 2001, Z ORTHOP GRENZGEB, V139, P8, DOI 10.1055/s-2001-11864 Kuttila S, 2005, INT J AUDIOL, V44, P164, DOI 10.1080/14992020500057608 Levine RA, 1999, AM J OTOLARYNG, V20, P351, DOI 10.1016/S0196-0709(99)90074-1 NEUHUBER WL, 1990, CENTRAL PROJECTIONS NEUHUBER WL, 2004, HNO PRAXIS HEUTE, V23 PFALLER K, 1988, J COMP NEUROL, V268, P91, DOI 10.1002/cne.902680110 Reisshauer A, 2006, HNO, V54, P125, DOI 10.1007/s00106-005-1349-4 Rubinstein B, 1993, Swed Dent J Suppl, V95, P1 Shore SE, 2003, NEUROSCIENCE, V119, P1085, DOI 10.1016/S0306-4522(03)00207-0 SHORE SE, 1992, HEARING RES, V62, P16, DOI 10.1016/0378-5955(92)90199-W Shore SE, 2005, EUR J NEUROSCI, V21, P3334, DOI 10.1111/j.1460-9568.2005.04142.x Spoendlin H, 1967, Arch Klin Exp Ohren Nasen Kehlkopfheilkd, V189, P346, DOI 10.1007/BF00440938 Spoendlin H, 1966, Acta Otolaryngol, V61, P423 TERRAHE K, 1985, LARYNG RHINOL OTOL V, V64, P292, DOI 10.1055/s-2007-1008141 Travell JG, 1983, MYOFASCIAL PAIN DYSF WOLFF HD, 1988, SONDERSTELLUNG KOPFG Zhou JX, 2004, J NEUROSCI RES, V78, P901, DOI 10.1002/jnr.20343 NR 25 TC 7 Z9 7 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0017-6192 J9 HNO JI HNO PD JUL PY 2008 VL 56 IS 7 BP 673 EP 677 DI 10.1007/s00106-008-1721-2 PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA 321PI UT WOS:000257318600003 PM 18560742 ER PT J AU Argstatter, H Krick, C Bolay, HV AF Argstatter, H. Krick, C. Bolay, H. V. TI Music therapy in chronic tonal tinnitus - Heidelberg model of evidence-based music therapy SO HNO LA German DT Article DE music therapy; chronic tonal tinnitus; functional magnetic resonance imaging; acoustic techniques; psychotherapeutic techniques ID RETRAINING THERAPY; NEURAL PLASTICITY AB Tinnitus has a very high prevalence, with more than one million patients in the German population needing treatment for it. About 50% of them suffer from so-called tonal tinnitus, i.e., tinnitus with a well-defined frequency. Although tinnitus is one of the most common symptoms in ENT medicine, the existing treatments are polypragmatic and often lack a scientific foundation. Based on this fact, a novel music therapy concept was developed, evaluated, and scientifically substantiated (with psychological, audiological, and functional imaging procedures in the diagnosis and treatment). The advantages of the described therapy are the integration of known and well-proven acoustic and psychotherapeutic techniques. They were converted to specific music therapy interventions (resonance training, neuroauditive cortex reprogramming, and tinnitus desensitization). More than 190 patients suffering from chronic tonal tinnitus were effectively treated. The results indicate that the therapy is highly advantageous in terms of treatment duration, effectiveness, and follow-up stability compared with customary interventions. Furthermore, the results of brain imaging strongly suggest the usefulness of further investigation and discussion in the realm of neuronal tinnitus modeling. C1 [Bolay, H. V.] SRH Hsch Heidelberg, Fak Musiktherapie, D-69123 Heidelberg, Germany. [Argstatter, H.] Deutsch Zentrum Musiktherapieforsch, Heidelberg, Germany. [Bolay, H. V.] Univ Saarland, Klin Diagnost & Intervent Neuroradiol, Homburg, Germany. RP Bolay, HV (reprint author), SRH Hsch Heidelberg, Fak Musiktherapie, Maassstr 26, D-69123 Heidelberg, Germany. EM bolay@fh-heidelberg.de CR Argstatter H, 2007, VERHALTENSTHER VERHA, V28, P115 ARGSTATTER H, 2007, INTERDISZIPLINARE PI, V55, P375 ARGSTATTER H, 2008, HEIDELBERGER MUSIKTH ARGSTATTER H, 2005, MUSIK TANZ KUNSTTHER, V16, P1, DOI 10.1026/0933-6885.16.1.1 Bartels H, 2007, OTOL NEUROTOL, V28, P178, DOI 10.1097/MAO.0b013e31802b3248 Cohen J, 1988, STAT POWER ANAL BEHA, V2nd Delb W, 2002, HNO, V50, P997, DOI 10.1007/s00106-002-0645-5 Goebel G, 1998, TINNITUS FRAGEBOGEN Hallam R. S., 1984, CONTRIBUTIONS MED PS, P31 HANDSCOMB L, 2006, ACTA OTO-LARYNGOL, V556, P59 Henry James A, 2004, J Am Acad Audiol, V15, P585, DOI 10.3766/jaaa.15.8.6 Henry JA, 2006, ACTA OTO-LARYNGOL, V126, P64, DOI 10.1080/03655230600895556 HERRAIZ C, 2006, ACTA OTO-LARYNGOL, V556, P80 Hesse G, 2002, HNO, V50, P973, DOI 10.1007/s00106-002-0739-0 Hillecke T., 2007, VERHALTENSTHERAPIE V, V28, P62 Hiller W, 2005, BEHAV RES THER, V43, P595, DOI 10.1016/j.brat.2004.03.012 Jourdain Robert, 1998, WOHLTEMPERIERTE GEHI Kaldo-Sandström Viktor, 2004, Am J Audiol, V13, P185, DOI 10.1044/1059-0889(2004/023) Konzag TA, 2006, HNO, V54, P599, DOI 10.1007/s00106-005-1350-y KRICK C, 2008, HUMAN BRAIN MA UNPUB Lambert M. J., 1992, HDB PSYCHOTHERAPY IN, P94 MOLLER AR, 1992, LARYNGOSCOPE, V102, P1165 Moller AR, 2006, PROG BRAIN RES, V157, P365, DOI 10.1016/S0079-6123(06)57022-0 Pilgramm M, 1999, HNO AKTUELL, V7, P261 Schmidt A, 2004, HNO, V52, P242, DOI 10.1007/s00106-003-0960-y Shulman A, 1999, Int Tinnitus J, V5, P92 Suga N, 2002, NEURON, V36, P9, DOI 10.1016/S0896-6273(02)00933-9 Weisz N, 2005, BRAIN, V128, P2722, DOI 10.1093/brain/awh588 *WORLD FED MUS THE, 1996, DEF MUS THER Zachriat Claudia, 2004, Cognitive Behaviour Therapy, V33, P187, DOI 10.1080/16506070410029568 NR 30 TC 16 Z9 16 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0017-6192 J9 HNO JI HNO PD JUL PY 2008 VL 56 IS 7 BP 678 EP 685 DI 10.1007/s00106-008-1722-1 PG 8 WC Otorhinolaryngology SC Otorhinolaryngology GA 321PI UT WOS:000257318600004 PM 18566786 ER PT J AU Hesse, G AF Hesse, G. TI Neurootologic and psychosomatic habituation therapy - Treatment approaches in chronic tinnitus SO HNO LA German DT Article DE chronic tinnitus; auditory perception; habituation; hearing therapy; pathologic evaluation ID TRANSCRANIAL MAGNETIC STIMULATION; RETRAINING THERAPY; MUSIC-THERAPY; SOUND AB Modern tinnitus therapy, especially for chronic tinnitus accompanied by psychosomatic disturbances, is based on an understanding of the controlled network of auditory perception. The symptom of tinnitus derives from damage or defective coding in this system, mainly the inner ear. It becomes an independent disease as a result of disturbed auditory perception with pathologic evaluation and emotional association in the cortex. We present different therapeutic approaches based on these models. The therapy aims to eliminate or diminish the symptom of tinnitus through retraining, cognitive restructuring, or enhancement of efferent filter mechanisms in the auditory pathway. Psychosomatic stabilization of patients is an important preliminary condition for effective habituation; therefore, an integrative neurootologic and psychosomatic therapy is proposed that requires an interdisciplinary therapeutic team and can be mostly carried out in an outpatient setting. C1 Univ Witten Herdecke, HNO Lehrstuhl, Ohr & Hor Inst Hessen, D-34454 Bad Arolsen, Germany. RP Hesse, G (reprint author), Univ Witten Herdecke, HNO Lehrstuhl, Ohr & Hor Inst Hessen, Grose Allee 50, D-34454 Bad Arolsen, Germany. EM drgerhardhesse@googlemail.com CR *ADANO, 2000, ADANO SITZ Andersson G, 1999, BRIT J AUDIOL, V33, P201 Argstatter H, 2007, HNO, V55, P375, DOI 10.1007/s00106-006-1478-4 Burian K, 1986, HORTRAINING TRAINING CRAMER A, 2002, GRUNDLAGEN MOGLICHKE DAMELIO R, 2003, NERVENARZT, V74, P104 DAMELIO R, 2005, HNO PRAXIS HEUTE, P61 Delb W, 2002, HNO, V50, P997, DOI 10.1007/s00106-002-0645-5 DELB W, 2002, TINNITUS MANUAL TINN Goebel G, 1998, TINNITUS FRAGEBOGEN GOEBEL G, 2004, PSYCHONEUROENDOCRINO, V30, P330, DOI 10.1055/s-2004-829995 GOEBEL G, 1997, HNO, V9, P664 GREEN S, 1987, PHYSL PSYCHOL INTRO, P199 HESSE G, 2006, TRENDS PSYCHOTHERAPY, P53 HESSE G, 2001, HNO PRAXIS HEUTE, P197 Hesse G, 2002, HNO, V50, P973, DOI 10.1007/s00106-002-0739-0 HESSE G, 2007, MED WELT, V58, P156 HESSE G, 2000, PRAXIS AUDIOMETRIE Hesse G, 2007, HNO, V55, P328, DOI 10.1007/s00106-007-1570-4 JASTREBOFF PJ, 1993, BRIT J AUDIOL, V27, P7, DOI 10.3109/03005369309077884 Jastreboff PJ, 2004, TINNITUS RETRAINING JASTREBOFF PJ, 1988, LARYNGOSCOPE, V98, P280 Jastreboff PJ, 2007, PROG BRAIN RES, V166, P415, DOI 10.1016/S0079-6123(07)66040-3 Kiessling J, 2006, HNO, V54, P573, DOI 10.1007/s00106-006-1423-6 Konzag TA, 2006, HNO, V54, P599, DOI 10.1007/s00106-005-1350-y Kraus N, 1998, AUDIOL NEURO-OTOL, V3, P168, DOI 10.1159/000013788 Kroner-Herwig B., 1997, PSYCHOL BEHANDLUNG C Lamm K, 1999, HNO, V47, P155, DOI 10.1007/s001060050374 Langguth B, 2006, ACTA OTO-LARYNGOL, V126, P102, DOI 10.1080/03655230600895457 LENARZ T, 1998, 017064 AWMFLEITLINIE LENARZ T, 1998, TINNITUS, P111 Mazurek B, 2006, HNO, V54, P9, DOI 10.1007/s00106-005-1292-4 MAZUREK K, 2006, AUDIOL NEURO-OTOL, V11, P276 McKenna L., 2004, AUDIOL MED, V2, P41, DOI 10.1080/16513860410028735 Pilgramm M, 1999, HNO AKTUELL, V7, P261 Plewnia C, 2003, ANN NEUROL, V53, P263, DOI 10.1002/ana.10468 REPIK I, 2008, THESIS U WITTEN HERD RIENHOFF NK, 2001, Z KLIN PSYCHOL PSYCH, V31, P47 SCHAAF H, 2003, Z ALLG MED, V79, P389 Schaaf H, 2002, HNO, V50, P572, DOI 10.1007/s00106-002-0655-3 Schaaf H, 2003, HNO, V51, P1005, DOI 10.1007/s00106-003-0967-y Sheldrake JB, 1999, P 6 INT TINN SEM 199, P292 VANWEDEL H, 1997, HNO, V45, P690 VERNON J, 1990, AM J OTOLARYNG, V11, P44, DOI 10.1016/0196-0709(90)90169-V Wilson PH, 1998, BRIT J AUDIOL, V32, P273, DOI 10.3109/03005364000000078 Zachriat Claudia, 2004, Cognitive Behaviour Therapy, V33, P187, DOI 10.1080/16506070410029568 Zenner HP, 2003, HNO, V51, P687, DOI 10.1007/s00106-003-0939-2 ZENNER HP, 2005, HNO PRAX HEUTE, P85 NR 48 TC 10 Z9 10 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0017-6192 J9 HNO JI HNO PD JUL PY 2008 VL 56 IS 7 BP 686 EP 693 DI 10.1007/s00106-008-1723-0 PG 8 WC Otorhinolaryngology SC Otorhinolaryngology GA 321PI UT WOS:000257318600005 PM 18560741 ER PT J AU Hesse, G Andres, R Schaaf, H Laubert, A AF Hesse, G. Andres, R. Schaaf, H. Laubert, A. TI DPOAE and lateral inhibition in chronic tinnitus SO HNO LA German DT Article DE DPOAE; tinnitus; outer hair cell activity; auditory pathway; efferent control ID PRODUCT OTOACOUSTIC EMISSION; DIFFERING SPONTANEOUS RATE; AUDITORY-NERVE FIBERS; NORMAL-HEARING; CENTRAL PROJECTIONS; GROWTH FUNCTIONS; MECHANISMS; EFFERENT; SYSTEM; CORTEX AB Introduction. According to our audiological data, 90% of tinnitus patients have deficits in inner ear function as a generator of tinnitus, mainly in the outer hair cells (OHC). This can be verified by registration of distortion products of otoacoustic emissions (DPOAE). Thus, the main origin of tinnitus is peripheral, and most patients suffer from accompanying hearing loss, even though it is sometimes mild or subjectively not even felt. Whether or not the tinnitus is disturbing, however, is determined through further auditory processing of the "signal" tinnitus and its psychological validation. With almost 50% of our tinnitus and hyperacusis patients, we find hyperfunctioning of the OHC, possibly originating from reduced or ineffective efferent control in the auditory pathway. Efferent activity can be measured by acoustic stimulation of the contralateral ear, which normally reduces the DPOAE amplitudes via efferent inhibition. Method and patients. DPOAE were recorded with 67 tinnitus patients (127 ears) with and without contralateral acoustic stimulation. Twenty-one persons (41 ears) served as controls. Results. With 64% of the tinnitus patients, DPOAE amplitudes were not reduced significantly, compared with 34% of the controls. The medium amplitude reduction for controls was 1.76 dB, whereas for the tinnitus patients it was significantly less (0.91 dB). Conclusion. For a considerable number of tinnitus patients, efferent control of OHC activity is restricted, but this seems to be confined to a certain type of tinnitus only. C1 [Hesse, G.; Schaaf, H.] Ohr & Hor Inst Hessen, D-34454 Bad Arolsen, Germany. [Andres, R.] HNO Praxis, Cuxhaven, Germany. [Laubert, A.] Univ Witten Herdecke, Herdecke, Germany. RP Hesse, G (reprint author), Ohr & Hor Inst Hessen, Grosse Allee 3, D-34454 Bad Arolsen, Germany. EM drgerhardhesse@googlemail.com CR Arnold W, 1996, ORL J OTO-RHINO-LARY, V58, P195 Bartnik Grazyna, 2007, Seminars in Hearing, V28, P303, DOI 10.1055/s-2007-990717 BREHMER D, 2000, LARYNGO RHINO OTOL, V79, P533 CHERYCROZE S, 1994, BRIT J AUDIOL, V28, P255, DOI 10.3109/03005369409086575 CHERYCROZE S, 1993, ACTA OTO-LARYNGOL, V113, P285, DOI 10.3109/00016489309135810 Eggermont J. 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Viertler, P. Knopp, M. Pfaffenberger, N. Guenther, V. TI Quality of partnerships in patients with tinnitus SO HNO LA German DT Article DE tinnitus; subjective tinnitus stress; partnership; depression ID PSYCHIATRIC DIAGNOSES; OF-LIFE; DISTRESS AB Background. Chronic tinnitus can massively impair the quality of life of patients affected with this disorder. Whether the constant ringing sounds and head noises heard by the sufferer have a stressful effect on the individual's partner has not been investigated so far. Patients and methods. A total of 32 members of the Tyrolean tinnitus self-help group suffering from chronic tinnitus and their partners with whom they shared a common household for a minimum period of 2 years underwent psychological investigation with regard to their subjectively experienced tinnitus-related stress, the quality of their partnership, emotional support they received, style of communication with their partners, and depression. Results. Our results show that it is not the extent of subjective tinnitus that is associated with impaired partnership quality, but rather the extent of tinnitus-associated depression. Conclusions. The results suggest that in clinical practice, less emphasis should be placed on the dynamics of family and partnership aspects and more attention should be paid to the possible presence of symptoms of depression and their treatment. C1 [Stuerz, K.; Viertler, P.; Knopp, M.; Pfaffenberger, N.; Guenther, V.] Univ Klin Psychiat, Abt Klin Psychol Psychotherapeut Ambulanz, A-6020 Innsbruck, Austria. RP Gunther, V (reprint author), Univ Klin Psychiat, Abt Klin Psychol Psychotherapeut Ambulanz, Anichstr 35, A-6020 Innsbruck, Austria. EM verena.guenther@uki.at CR Arnold W, 2000, LARYNGO RHINO OTOL, V79, P622, DOI 10.1055/s-2000-8299 BECK AT, 1961, ARCH GEN PSYCHIAT, V4, P561 BODENMANN G, 1991, Z FAMILIENFORSCHUNG, V3, P4 Bodenmann G., 2001, STRESS PARTNERSCHAFT BODENMANN G, 1995, Z FAMILIENFORSCHUNG, V7, P119 Budd RJ, 1995, J PSYCHOSOM RES, V39, P1015, DOI 10.1016/0022-3999(95)00512-9 BURK RJ, 1977, J PSYCHOL, V95, P1212 COYNE JC, 1986, J CONSULT CLIN PSYCH, V54, P454, DOI 10.1037/0022-006X.54.4.454 D'Amelio R, 2004, HNO, V52, P599, DOI 10.1007/s00106-003-0944-5 DOBIE RA, 1992, ACTA OTO-LARYNGOL, V112, P242 *DTSCH TINN LIG SO, 2004, TINN IST NICHT GLEIC Erlandsson SI, 2000, BRIT J AUDIOL, V34, P11, DOI 10.3109/03005364000000114 Fitzpatrick M.A, 1988, PERSPECTIVES MARITAL, V1-28 GEFKEN R, 1992, OHRGERAUSCHE PSYCHOS, P53 GOEBEL G, 1993, PSYCHO, V19, P447 Goebel G, 1998, INSTRUMENT ERFASSUNG Greimel KV, 1999, HNO, V47, P130, DOI 10.1007/s001060050372 GUENTHER V, 2005, DEPRESSIONSTHERAPIEN, P108 HAHLWEG K, 1986, PARTNERSCHAFTLICHE I HALLAM RS, 1988, BRIT J CLIN PSYCHOL, V27, P213 Hank G, 1990, DIAGNOSTISCHE VERFAH HARROPGRIFFITHS J, 1987, J PSYCHOSOM RES, V31, P613, DOI 10.1016/0022-3999(87)90040-7 Harter M, 2004, HNO, V52, P125, DOI 10.1007/s00160-003-0889-8 HEIL FE, 1991, PARTNERWAHL PARTNERS, P1 Hiller W, 2001, OHRGERAUSCHE PSYCHOS, P47 HILLER W, 1992, OHRGERAUSCHE PSYCHOS, P65 KALLERT J, 1997, MEIN PARTNER HAT TIN KONIGKUSKE J, 1977, PARTNERBERATUNG, V14, P47 KRAUS MR, 1995, UNIVERSITAS, V8, P768 Kroner-Herwig B., 1997, PSYCHOL BEHANDLUNG C NEWMAN CW, 1996, ARCH OTOLARYNGOL, V122, P43 Pilgramm M, 1999, HNO AKTUELL, V7, P261 Schildt A, 2006, HNO, V54, P781, DOI 10.1007/s00106-006-1447-y SCOTT B, 2001, OHRGERAUSCHE PSYCHOS SIMPSON RB, 1988, J OTOLARYNGOL, V17, P325 *TINN FOR, 1999, ERG EP TINN STUD DTL, V3, P58 World Health Organization, 1997, ICIDH 2 INT CLASS IM NR 37 TC 1 Z9 1 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0017-6192 J9 HNO JI HNO PD JUL PY 2008 VL 56 IS 7 BP 701 EP 706 DI 10.1007/s00106-007-1603-z PG 6 WC Otorhinolaryngology SC Otorhinolaryngology GA 321PI UT WOS:000257318600007 PM 17874056 ER PT J AU Bosel, C Mazurek, B Haupt, H Peroz, I AF Boesel, C. Mazurek, B. Haupt, H. Peroz, I. TI Chronic tinnitus and craniomandibular disorders. Effectiveness of dental functional therapy on perceived tinnitus distress SO HNO LA German DT Article DE tinnitus; ear symptoms; CMD; temporomandibular joint ID TEMPOROMANDIBULAR DISORDERS; JOINT AB Background. Whether the co-occurrence of signs and symptoms of a craniomandibular disorder (CMD) and chronic tinnitus are coincidental or causal is controversial. Therefore, the effects of splint therapy and self-therapy on perceived tinnitus were evaluated. Patients and methods. Fifty-nine patients with chronic tinnitus were divided into three groups. In a cross-over design, two groups received the two different treatments and were compared with a control group. All patients received the initial basic tinnitus therapy. Results. No significant correlation was established between the groups receiving treatment and the control group that would validate a link between tinnitus and CMD. Conclusion. The results of this study suggest a coincidental relationship between the two complexes of symptoms. C1 [Peroz, I.] Charite Univ Med Berlin, Inst Zahnarztliche Protheik Alterzahnmed & Funkti, ChariteCentrum Zahn Mund & Kieferheilkunde, D-13353 Berlin, Germany. [Boesel, C.] DENTSPLY DeTrey GmbH, Constance, Germany. [Mazurek, B.; Haupt, H.] Charite Univ Med Berlin, Tinnituszentrum, Klin Hals Nasen & Ohrenheilkunde, Berlin, Germany. RP Peroz, I (reprint author), Charite Univ Med Berlin, Inst Zahnarztliche Protheik Alterzahnmed & Funkti, ChariteCentrum Zahn Mund & Kieferheilkunde, Augustenburger Pl 1, D-13353 Berlin, Germany. EM ingrid.peroz@charite.de CR AHLERS M, 2005, DTSCH ZAHNARZTL Z, V60 ARLEN H, 1984, CLIN MANAGEMENT HEAD, P171 BUSH FM, 1987, J PROSTHET DENT, V58, P495, DOI 10.1016/0022-3913(87)90282-4 CHAN SWY, 1994, CLIN OTOLARYNGOL, V19, P370, DOI 10.1111/j.1365-2273.1994.tb01251.x CHOLE RA, 1992, ARCH OTOLARYNGOL, V118, P817 Costen JB, 1934, ANN OTO RHINOL LARYN, V43, P1 Dworkin Samuel F., 1992, Journal of Craniomandibular Disorders, V6, P301 GOEBEL G, 2000, TINNITUS FRAGEBOGEN HAZELL JWP, 1987, TINNITUS, P46 Helkimo M, 1974, Sven Tandlak Tidskr, V67, P101 KLOCKHOFF I, 1993, SWED DENT J, V95, P1 LENARZ T, 1992, TINNITUS, P71 Lenarz T, 1999, HNO, V47, P14 Mazurek B, 2005, GESUNDHEITSWESEN, V67, P485, DOI 10.1055/s-2005-858379 Meikle M, 1984, J Laryngol Otol Suppl, V9, P17 Myrhaug H, 1964, Br J Oral Surg, V2, P28, DOI 10.1016/S0007-117X(64)80004-4 Peroz I, 2003, HNO, V51, P544, DOI 10.1007/s00106-002-0750-5 Pilgramm M, 1999, P 6 INT TINN SEM CAM, P64 PINTO OF, 1962, J PROSTHET DENT, V12, P95, DOI 10.1016/0022-3913(62)90014-8 RUBINSTEIN B, 1990, Journal of Craniomandibular Disorders, V4, P186 Rubinstein B, 1993, Swed Dent J Suppl, V95, P1 SCHNEIDER WR, 1994, HNO, V42, P22 VERNON J, 1992, EUR ARCH OTO-RHINO-L, V249, P93 Wahlund K, 1998, J OROFAC PAIN, V12, P42 NR 24 TC 3 Z9 4 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0017-6192 J9 HNO JI HNO PD JUL PY 2008 VL 56 IS 7 BP 707 EP 713 DI 10.1007/s00106-007-1602-0 PG 7 WC Otorhinolaryngology SC Otorhinolaryngology GA 321PI UT WOS:000257318600008 PM 17764004 ER PT J AU Schrock, A Strach, K Kuhnemund, M Bootz, F Eichhorn, KW AF Schroeck, A. Strach, K. Kuehnemund, M. Bootz, F. Eichhorn, K. W. TI Rare cause of pulse-synchronous tinnitus SO HNO LA German DT Article ID INTERNAL CAROTID-ARTERY C1 [Schroeck, A.; Strach, K.; Kuehnemund, M.; Bootz, F.; Eichhorn, K. W.] Univ Bonn, Klin & Poliklin Hals Nasen & Ohrenkrankheiten, D-53105 Bonn, Germany. RP Schrock, A (reprint author), Univ Bonn, Klin & Poliklin Hals Nasen & Ohrenkrankheiten, Sigmund Freud Str 25, D-53105 Bonn, Germany. EM andreasschroeck@web.de CR Heimlich F, 1999, HNO, V47, P986, DOI 10.1007/s001060050480 LASJAUNIAS P, 1984, ANAT CLIN, V6, P133, DOI 10.1007/BF01773165 Sauvaget E, 2006, ARCH OTOLARYNGOL, V132, P86, DOI 10.1001/archotol.132.1.86 VERA P, 1977, THESIS TOULOUSE Windfuhr Jochen P, 2004, Ann Otol Rhinol Laryngol Suppl, V192, P1 NR 5 TC 1 Z9 1 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0017-6192 J9 HNO JI HNO PD JUL PY 2008 VL 56 IS 7 BP 714 EP 716 DI 10.1007/s00106-008-1713-2 PG 3 WC Otorhinolaryngology SC Otorhinolaryngology GA 321PI UT WOS:000257318600009 PM 18488184 ER PT J AU Dolberg, D Schaaf, H Hesse, G AF Dolberg, D. Schaaf, H. Hesse, G. TI Tinnitus in primarily schizophrenic patients SO HNO LA German DT Article DE tinnitus; schizophrenia; psychiatric treatment; acoustic hallucinations; differentiation ID THERAPY; COMORBIDITY; SYMPTOMS AB Background. Tinnitus, a ringing in the ear perceived only by the person concerned, occurs not only in the general population but also among patients suffering from schizophrenia. They may be afflicted by tinnitus and acoustic hallucinations at the same time. Misinterpreting their schizophrenic illness, patients prefer to consult a family doctor or an ear, nose and throat (ENT) specialist rather than a psychiatrist if they mistake their acoustic hallucinations for tinnitus. Conversely, in schizophrenia patients, tinnitus of recent onset can be mistaken for acoustic hallucination and may be treated with neuroleptics rather than by a symptom-oriented management approach. This paper aims to present treatment approaches and criteria for distinguishing between acoustic hallucinations, which occur often in schizophrenia, and tinnitus, and to highlight treatment options. Patients and methods. From October 1999 to October 2004, we investigated 31 schizophrenic inpatients (17 men [55%], 14 women [45%] aged between 29 and 60 years, mean: 44 years) suffering from tinnitus. A total of 11 patients were treated mainly for tinnitus in a specialized neurootological clinic, 11 were treated in a psychiatric clinic, and 9 patients were treated in a psychiatric day center. All patients were examined using psychiatric and neurootological standards. Results. Differences were found between tinnitus and acoustic hallucinations in the patients' descriptions and the audiometric outcomes. Tinnitus was mainly found in higher frequencies ranging from 4000 to 8000 Hz. Tinnitus was masked at an average of 9.3 dB and a maximum of 15 dB above the auditory threshold. Six patients (19%) had normal hearing, while ten patients (32%) had unilateral hearing loss and 15 patients had bilateral hearing loss. Hearing aids were indicated in 14 patients, but only five patients accepted them. Conclusion. Schizophrenic patients suffering from tinnitus benefit from basic standards of tinnitus treatment. However, psychiatric specialists should also provide the drug treatment that is often necessary as well as psychoeducation for schizophrenia. C1 [Dolberg, D.] Klin Psychiat & Psychotherapie Eichberg, Zentrum Soziale Psychiat Rheinblick, D-65346 Eltville, Germany. [Schaaf, H.; Hesse, G.] Tinnitus Klin, Psychosomat Klin Bad Arolsen, Bad Arolsen, Germany. RP Dolberg, D (reprint author), Klin Psychiat & Psychotherapie Eichberg, Zentrum Soziale Psychiat Rheinblick, Kloster Eberbach Str 4, D-65346 Eltville, Germany. EM info@zsp-rheinblick.de CR *ADANO, 2004, LEITL TINN BAUML J, 2003, PSYCHOEDUKATION BEI, P376 Bauml J, 1996, NERVENHEILKUNDE, V15, P145 BIESINGER E, 1999, DTSCH ARZTEBL A, V96, P2817 BLEULER E, 1911, DERMENTIA PRAECOX OD Bleuler E, 1930, Z GESAMTE NEUROL PSY, V124, P607, DOI 10.1007/BF02865117 GOEBEL G, 2005, HNO PRAXIS HEUTE, V25 Goebel G, 2001, OHRGERAUSCHE PSYCHOS GOEBEL G, 2003, MANUAL PRAXIS, V20, P117 GOEBEL G, 2004, PSYCHONEUROENDOCRINO, V30, P330, DOI 10.1055/s-2004-829995 GOEBEL G, 1998, TINNITUS FRAGBOGEN H Hesse G, 2001, LARYNGO RHINO OTOL, V80, P503, DOI 10.1055/s-2001-17131 HESSE G, 2007, MED WELT, V4, P156 Hesse G, 2001, HNO, V49, P764, DOI 10.1007/s001060170052 HESSE G, 1999, RETRAINING TINNITUST, P109 JASTREBOFF PJ, 1993, BRIT J AUDIOL, V27, P7, DOI 10.3109/03005369309077884 Johns LC, 2002, BRIT J CLIN PSYCHOL, V41, P81, DOI 10.1348/014466502163813 Kiessling JJK, 1997, VERSORGUNG REHABILIT Konzag VTA, 2005, Z PSYCHOSOM MED PSYC, V51, P247 Lenarz T, 1998, LARYNGO RHINO OTOL, V77, P54, DOI 10.1055/s-2007-996932 Meister SD, 2004, NERVENARZT, V75, P467, DOI 10.1007/s00115-003-1597-z Nam EC, 2005, J LARYNGOL OTOL, V119, P352 Pilgramm M, 1999, HNO AKTUELL, V7, P261 Roder V, 2001, NERVENARZT, V72, P709, DOI 10.1007/s001150170050 Schaaf H, 2003, NERVENARZT, V74, P72, DOI 10.1007/s00115-001-1222-y SCHAAF H, 2001, PSYCHOTHERAPIE TINNI, P142 Schmidt A, 2004, HNO, V52, P242, DOI 10.1007/s00106-003-0960-y Schneider K, 1967, KLIN PSYCHOPATHOLOGI SELING B, 2005, HNO PRAXIS HEUTE, V25 TOLLE R, 1996, PSYCHIATRIE Wiedemann G, 2003, NERVENARZT, V74, P76, DOI 10.1007/s00115-002-1330-3 Zenner HP, 1998, HNO, V46, P699, DOI 10.1007/s001060050299 NR 32 TC 4 Z9 4 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0017-6192 J9 HNO JI HNO PD JUL PY 2008 VL 56 IS 7 BP 719 EP + DI 10.1007/s00106-008-1765-3 PG 7 WC Otorhinolaryngology SC Otorhinolaryngology GA 321PI UT WOS:000257318600011 PM 18551261 ER PT J AU Goto, F Nakai, K Ogawa, K AF Goto, F. Nakai, K. Ogawa, K. TI Autogenic training for patients with intractable dizziness or tinnitus: a method to control the amount of prescribed medications such as anxiolytics and narcoleptics SO INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY LA English DT Meeting Abstract CT 26th Collegium Internationale Neuro-Psychopharmacologicum Congress (CINP) CY JUL 13-17, 2008 CL Munich, GERMANY C1 [Goto, F.; Nakai, K.] Hino Municipal Hosp, Hino, Tokyo, Japan. [Ogawa, K.] Keio Univ, Shinjuku Ku, Tokyo 108, Japan. RI Goto, Fumiyuki/C-6337-2011 NR 0 TC 0 Z9 0 PU CAMBRIDGE UNIV PRESS PI NEW YORK PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA SN 1461-1457 J9 INT J NEUROPSYCHOPH JI Int. J. Neuropsychopharmacol. PD JUL PY 2008 VL 11 SU 1 BP 276 EP 277 PG 2 WC Clinical Neurology; Neurosciences; Pharmacology & Pharmacy; Psychiatry SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry GA 343LO UT WOS:000258855501425 ER PT J AU Aslan, S Yavuz, H Cagici, AC Kizilkilic, O AF Aslan, S. Yavuz, H. Cagici, A. C. Kizilkilic, O. TI Embolisation of an extensive arteriovenous malformation of the temporal region as an alternate treatment: case report SO JOURNAL OF LARYNGOLOGY AND OTOLOGY LA English DT Article DE temporal bone; arteriovenous malformation; embolisation ID ETHANOL SCLEROTHERAPY; VENOUS MALFORMATION; MANAGEMENT AB Objectives: To report the case of a spontaneous arteriovenous malformation involving the auricula, external auditory meatus, middle ear and part of the petrous apex, and also to provide updated information about its management. Case report: A 33-year-old woman presented complaining of accelerated growth of a retro-auricular swelling during her latest pregnancy, together with pain, pulsatile tinnitus and ear discharge. An arteriovenous malformation occupying the right auricula, external auditory canal, mastoid proccess of the temporal bone and the lateral half of the petrous segment was diagnosed, using temporal computerised tomography and magnetic resonance imaging. The lesion was embolised with polyvinyl alcohol particles at angiography. Excision of the a rteriovenous malformation nidus was performed. Three years post-operatively, magnetic resonance imaging showed no residual lesion or recurrence at the temporal bone and petrous apex, although a few scanty, serpiginous, vascular remnants had persisted. Conclusions: In the head and neck, arteriovenous malformations usually occur intracranially; they are rare outside the cranium. To our knowledge, there have been no previously published cases of such an extensive arteriovenous malformation involving the temporal region. Apropos of our case, the definition, clinical findings, diagnostic approaches and therapeutic management of arteriovenous malformations are discussed. C1 Baskent Univ, Fac Med, Dept Otorhinolaryngol, TR-06490 Ankara, Turkey. RP Aslan, S (reprint author), Cemalpasa Mh 10 Sk,Elite Hn Apt 8-10, TR-01140 Seyhan Adana, Turkey. EM drsundus@hotmail.com RI Yavuz, Haluk/F-6315-2015 OI Yavuz, Haluk/0000-0003-3320-204X CR Bapuraj JR, 2002, J LARYNGOL OTOL, V116, P42 Kohout MP, 1998, PLAST RECONSTR SURG, V102, P643, DOI 10.1097/00006534-199809030-00006 Lee BB, 2001, J VASC SURG, V33, P764, DOI 10.1067/mva.2001.112209 Lee BB, 2003, J VASC SURG, V37, P533, DOI 10.1067/mva.2003.91 Lee BB, 2004, J VASC SURG, V39, P590, DOI 10.1016/j.jvs.2003.10.048 MCGILL T, 1993, OTOLARYNGOLOGY HEAD, P333 Pham TH, 2001, LARYNGOSCOPE, V111, P1390, DOI 10.1097/00005537-200108000-00014 Raghu M, 2004, J LARYNGOL OTOL, V118, P912 Shinohara K, 2005, OTOLARYNG HEAD NECK, V132, P345, DOI 10.1016/j.otohns.2004.09.043 VINSON AM, 1988, SOUTHERN MED J, V81, P1052, DOI 10.1097/00007611-198808000-00028 Wu JK, 2005, PLAST RECONSTR SURG, V115, P985, DOI 10.1097/01.PRS.0000154207.87313.DE Yakes WF, 1996, CARDIOVASC INTER RAD, V19, P65 YOSHIDA Y, 2005, CLIN EXP DERMATOL, V31, P151 NR 13 TC 5 Z9 5 PU CAMBRIDGE UNIV PRESS PI CAMBRIDGE PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND SN 0022-2151 J9 J LARYNGOL OTOL JI J. Laryngol. Otol. PD JUL PY 2008 VL 122 IS 7 BP 737 EP 740 DI 10.1017/S0022215108001977 PG 4 WC Otorhinolaryngology SC Otorhinolaryngology GA 329CS UT WOS:000257845100017 PM 18331657 ER PT J AU Mendis, D Johnston, M AF Mendis, D. Johnston, M. TI An unusual case of prolonged tinnitus following low-dose amitriptyline SO JOURNAL OF PSYCHOPHARMACOLOGY LA English DT Article DE amitriptyline; ototoxicity; tinnitus ID GLUTAMATE; RATS AB We report on a case of unilateral tinnitus after a short course of low-dose amitriptyline for neuralgic foot pain. This has been described in the literature previously at much higher doses and is associated with prolonged administration; we present our case with a review of the current literature in-order to raise awareness of this possible complication of anti-depressant therapy. We also propose a novel hypothesis for the pharmacological basis of amitriptyline-induced tinnitus. C1 [Mendis, D.] Queens Hosp, Dept ENT Surg, Burton Upon Trent DEL3 0RB, England. [Johnston, M.] Derby Royal Infirm NHS Fdn Trust, Dept ENT Surg, Derby, England. RP Mendis, D (reprint author), Queens Hosp, Dept ENT Surg, Belvedere Rd, Burton Upon Trent DEL3 0RB, England. EM dulanimendis@yahoo.com CR BAVAR N, 2001, J OTOLARYNGOL, V30, P300 FEDER R, 1990, J CLIN PSYCHIAT, V51, P85 KIM JS, 1982, ARCH PSYCHIAT NERVEN, V232, P391, DOI 10.1007/BF00345595 MILES SW, 1980, NEW ZEAL MED J, V92, P66 Nordang L, 2000, ACTA OTO-LARYNGOL, V120, P359, DOI 10.1080/000164800750000568 ROLAND NJ, 2001, KEY TOPICS OTOLARYNG, P228 Tai YH, 2006, PAIN, V124, P77, DOI 10.1016/j.pain.2006.03.018 TANDON R, 1987, J CLIN PSYCHIAT, V48, P109 VANDEWATER TR, 2006, OTOLARYNGOLOGY BASIC, P347 1996, AMITRIPTYLINE TABLES NR 10 TC 7 Z9 7 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 0269-8811 J9 J PSYCHOPHARMACOL JI J. Psychopharmacol. PD JUL PY 2008 VL 22 IS 5 BP 574 EP 575 DI 10.1177/0269881107082126 PG 2 WC Clinical Neurology; Neurosciences; Pharmacology & Pharmacy; Psychiatry SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry GA 341KU UT WOS:000258714200015 PM 18308819 ER PT J AU Trenkwalder, C Benes, H Poewe, W Oertel, WH Garcia-Borreguero, D de Weerd, AW Ferini-Strambi, L Montagna, P Odin, P Stiasny-Kolster, K Hogl, B Chaudhuri, KR Partinen, M Schollmayer, E Kohnen, R AF Trenkwalder, Claudia Benes, Heike Poewe, Werner Oertel, Wolfgang H. Garcia-Borreguero, Diego de Weerd, Al W. Ferini-Strambi, Luigi Montagna, Pasquale Odin, Per Stiasny-Kolster, Karin Hoegl, Birgit Chaudhuri, K. Ray Partinen, Markku Schollmayer, Erwin Kohnen, Ralf CA SP790 Study Grp TI Efficacy of rotigotine for treatment of moderate-to-severe restless legs syndrome: a randomised, double-blind, placebo-controlled trial SO LANCET NEUROLOGY LA English DT Article ID LIMB MOVEMENT-DISORDER; TRANSDERMAL ROTIGOTINE; RATING-SCALE; AUGMENTATION; ROPINIROLE; MANAGEMENT; SLEEP; ASSOCIATION; PRAMIPEXOLE; VALIDATION AB Background Continuous administration of a dopamine agonist could be used to treat patients with restless legs syndrome. Our aim was to investigate the efficacy of transdermal rotigotine in the treatment of idiopathic restless legs syndrome. Methods in this randomised, double-blind, placebo-controlled trial, 458 patients with moderate-to-severe idiopathic restless legs syndrome (average baseline International Restless Legs Syndrome Study Group severity rating scale [IRLS] sum score of 28.1) were randomly assigned to receive transdermal rotigotine 1 mg over 24 h (n=115), 2 mg over 24 h (n=112), or 3 mg over 24 h (n=114), or to receive placebo (n=117). Study medication was delivered via patches, applied once a day for 6 months. Randomisation was done with a computer-generated randomisation list, stratified by Centre. Primary efficacy outcomes were absolute change from baseline to end of maintenance in IRLS sum score and in the clinical global impressions (CGI) item 1 score, assessed by analysis of covariance in the intention-to-treat population. This trial is registered with ClinicalTrials.gov, number NCT00136045. Findings Efficacy analyses were done on 112 patients in the I mg group, 109 in the 2 mg group, 112 in the 3 mg group, and 114 in the placebo group. Mean change in IRLS sum score from baseline at the end of the maintenance phase was -13.7 (SE 0.9) in the 1 mg group, -16.2(0.9) in the 2 mg group, -16.8(0.9) in the 3 mg group, and -8.6(0.9) in the placebo group (p<0.0001 for treatment difference vs placebo with each dose). Mean change in CGI item 1 score from baseline at the end of the maintenance phase was -2.09(0.14) in the 1 mg group, -2.41(0.14) in the 2 mg group, -2.55(0.14) in the 3 mg group, and -1.34(0.14) in the placebo group (p<0.0001 for treatment difference vs placebo with each dose). Skin reactions, mostly mild or moderate, were seen in 145 (43%) of 341 patients who received rotigotine and in two (2%) of 117 who received placebo. Ten patients had serious adverse event that were deemed to be related to rotigotine: elevation of liver enzymes (one patient), worsening of tinnitus (one patient), non-response to anticoagulation (one patient), electrocardiogram changes (one patient), and application-site reactions (six patients). No admissions to hospital were needed for the application-site reactions, and they all resolved within a short time of patch removal without any other therapeutic intervention. The rate of typical dopaminergic side-effects in patients who received rotigotine was low; no signs of augmentation were noted. Interpretation 24 h transdermal delivery of low-dose rotigotine could be used to relieve the night-time and daytime symptoms of restless legs syndrome. C1 [Trenkwalder, Claudia] Univ Gottingen, Dept Clin Neurophysiol, Gottingen, Germany. [Benes, Heike] Univ Rostock, Somni Bene Inst Clin Res & Sleep Med, Rostock, Germany. [Benes, Heike] Univ Rostock, Dept Neurol, Rostock, Germany. [Poewe, Werner; Hoegl, Birgit] Innsbruck Med Univ, Dept Neurol, Innsbruck, Austria. [Oertel, Wolfgang H.; Stiasny-Kolster, Karin] Univ Marburg, Dept Neurol, Marburg, Germany. [Garcia-Borreguero, Diego] Sleep Res Inst, Madrid, Spain. [de Weerd, Al W.] Sleep Ctr SEIN Zwolle, Zwolle, Netherlands. [Ferini-Strambi, Luigi] Univ Vita Salute San Raffaele, Sleep Disorders Ctr, Milan, Italy. [Montagna, Pasquale] Univ Bologna, Dept Neurol Sci, Bologna, Italy. [Odin, Per] Cent Hosp, Dept Neurol, Bremerhaven, Germany. [Chaudhuri, K. Ray] Kings Coll Hosp London, Ctr Excellence, Natl Parkinson Fdn, London, England. [Partinen, Markku] Rinnekoti Res Ctr, Skogby Sleep Clin, Espoo, Finland. [Schollmayer, Erwin] Schwarz Biosci GmbH, UCB Grp, Monheim, Germany. [Kohnen, Ralf] Univ Erlangen Nurnberg, IMEREM, Inst Med Res Management & Biometr, Nurnberg, Germany. [Kohnen, Ralf] Univ Erlangen Nurnberg, Dept Psychol, Nurnberg, Germany. RP Trenkwalder, C (reprint author), Paracelsus Elena Hosp, Ctr Parkinsonism & Movement Disorders, Klinikstr 16, D-34128 Kassel, Germany. 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PD JUL PY 2008 VL 7 IS 7 BP 595 EP 604 DI 10.1016/S1474-4422(08)70112-1 PG 10 WC Clinical Neurology SC Neurosciences & Neurology GA 320DJ UT WOS:000257213600016 PM 18515185 ER PT J AU Rettinger, G AF Rettinger, G. TI Untitled SO LARYNGO-RHINO-OTOLOGIE LA German DT Editorial Material ID PRIVATE ACCIDENT INSURANCE; TINNITUS C1 Univ Klin Hals Nasen Ohhren Heilkunde, D-89075 Ulm, Germany. RP Rettinger, G (reprint author), Univ Klin Hals Nasen Ohhren Heilkunde, Frauensteige 12, D-89075 Ulm, Germany. CR Michel O, 2006, LARYNGO RHINO OTOL, V85, P204, DOI 10.1055/s-2005-870349 Michel O, 2007, LARYNGO RHINO OTOL, V86, P27, DOI 10.1055/s-2006-944943 NR 2 TC 0 Z9 0 PU GEORG THIEME VERLAG KG PI STUTTGART PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY SN 0935-8943 J9 LARYNGO RHINO OTOL JI Laryngo-Rhino-Otol. PD JUL PY 2008 VL 87 IS 7 BP 476 EP 476 DI 10.1055/s-2008-1077332 PG 1 WC Otorhinolaryngology SC Otorhinolaryngology GA 323HN UT WOS:000257437300005 ER PT J AU Michel, O Brusis, T AF Michel, O. Brusis, T. TI Compensation for somatoform (psychogenic) tinnitus in private accident insurance SO LARYNGO-RHINO-OTOLOGIE LA German DT Article DE private accident insurance; psychogenic tinnitus; somatoform tinnitus; compensation; tinnitogenic psycho-syndrome AB Background: According to special arrangements in private accident insurance, it is now possible that tinnitus as exclusive sequel (psychogenic tinnitus) can be compensated. This new situation leads to the unanswered question of how such a psychogenic (somatoform) tinnitus should be compensated in regard to the valid compensation tables. Methodology and results: The differentiation between an otogenic and somatoform tinnitus allows a judgement as defined by the general terms and conditions of the private accident insurance. An individual compensation of 5% or of a complex, decompensated tinnitogenic psycho-syndrome 10% of the sum insured is proposed. Conclusions: All impairment of the psychic function as exhaustion, nervous excitability, sleeplessness, depression and concentration disturbances are included in this invalidity of 10%. In case of a tinnitogenic psycho-syndrome, the medical assessment should be done by a neurologist/psychiatrist. C1 [Michel, O.] Vrije Univ Brussels, Univ Ziekenhuis, Dienst KNO, B-1090 Brussels, Belgium. [Brusis, T.] Inst Begutachtung, Cologne, Germany. RP Michel, O (reprint author), Vrije Univ Brussels, Univ Ziekenhuis, Dienst KNO, Laarbeeklaan 101, B-1090 Brussels, Belgium. EM omichel@uzbrussel.be RI Michel, Olaf/B-3673-2012 OI Michel, Olaf/0000-0003-4289-5693 CR BRUSIS T, 1973, HNO, V21, P55 Feldmann H, 1969, Z Laryngol Rhinol Otol, V48, P528 Feldmann H, 2006, GUTACHTEN HALS NASEN GOEBEL G, 1994, HNO, V42, P166 Lenarz T, 1998, LARYNGO RHINO OTOL, V77, P531, DOI 10.1055/s-2007-997020 Michel O, 2006, LARYNGO RHINO OTOL, V85, P204, DOI 10.1055/s-2005-870349 Michel O, 2007, Versicherungsmedizin, V59, P73 Michel O, 2006, LARYNGO RHINO OTOL, V85, P354, DOI 10.1055/s-2005-921201 Michel O, 2007, LARYNGO RHINO OTOL, V86, P27, DOI 10.1055/s-2006-944943 NR 9 TC 1 Z9 1 PU GEORG THIEME VERLAG KG PI STUTTGART PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY SN 0935-8943 J9 LARYNGO RHINO OTOL JI Laryngo-Rhino-Otol. PD JUL PY 2008 VL 87 IS 7 BP 477 EP 481 DI 10.1055/s-2007-995510 PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA 323HN UT WOS:000257437300006 PM 18288623 ER PT J AU Mennemeier, M Chelette, KC Myhill, J Taylor-Cooke, P Bartel, T Triggs, W Kimbrell, T Dornhoffer, J AF Mennemeier, Mark Chelette, Kenneth C. Myhill, Jeffery Taylor-Cooke, Patricia Bartel, Twyla Triggs, William Kimbrell, Timothy Dornhoffer, John TI Maintenance Repetitive Transcranial Magnetic Stimulation Can Inhibit the Return of Tinnitus SO LARYNGOSCOPE LA English DT Article DE Transcranial magnetic stimulation; maintenance TMS; tinnitus; reaction time; positron emission tomography imaging ID RTMS; EXCITABILITY; CORTEX; MOTOR AB Objectives/Hypothesis: A single patient was tested to examine the safety and feasibility of using maintenance sessions of low-frequency repetitive transcranial magnetic stimulation (1 Hz rTMS) to reduce tinnitus loudness and prevent its return over time. Study Design: Interrupted time series with multiple replications. Methods: Tinnitus loudness was assessed using a visual analogue rating (VAR) with 0 = no tinnitus, and 100 = loudest tinnitus experienced; 1,800 TMS pulses delivered at 1 Hz and 110% of motor threshold were administered over the posterior, superior lateral temporal gyrus of the subject's right hemisphere until subjective tinnitus fell to a VAR of 25. TMS was reapplied as tinnitus returned to a VAR of 25 or higher. Cerebral metabolism was measured using positron emission tomography before and after treatment. Results: In this patient, tinnitus could be reduced to a VAR of 6 or lower each time it reoccurred using one to three maintenance sessions of rTMS. Tinnitus loudness remained at or below a VAR of 25 and was reported to be unobtrusive in daily life when last assessed 4 months after the third and final round of maintenance treatment. Asymmetric increased cerebral metabolism in the right hemisphere reduced following treatment and as tinnitus improved. Maintenance treatment, was well tolerated with no side effects. Conclusions: Although a case study cannot establish treatment efficacy, this study demonstrates for the first time that it is feasible to use maintenance rTMS to manage chronic tinnitus. Maintenance rTMS might impede cortical expansion of the tinnitus frequency into adjacent cortical areas, but group studies are necessary to confirm this speculation. C1 [Mennemeier, Mark; Chelette, Kenneth C.; Taylor-Cooke, Patricia; Dornhoffer, John] Univ Arkansas Med Sci, Dept Neurobiol & Dev Sci, Little Rock, AR 72205 USA. [Myhill, Jeffery; Dornhoffer, John] Univ Arkansas Med Sci, Dept Otolaryngol Head & Neck Surg, Little Rock, AR 72205 USA. [Bartel, Twyla] Univ Arkansas Med Sci, Dept Radiol, Div Nucl Med, Little Rock, AR 72205 USA. [Triggs, William] Univ Florida, Dept Neurol, Gainesville, FL USA. [Kimbrell, Timothy] Univ Arkansas Med Sci, Dept Psychiat, N Little Rock, AR USA. Cent Arkansas Vet Healthcare Syst, Mental Hlth Serv, N Little Rock, AR USA. RP Mennemeier, M (reprint author), Univ Arkansas Med Sci, Dept Neurobiol & Dev Sci, 4301 W Markham Slot 826, Little Rock, AR 72205 USA. EM msmennemeie@uams.edu FU National Institutes of Health; National Center for Research Resources Centers of Biomedical Research Excellence (COBRE) [RR20146]; National Institute of Neurological Disorders and Stroke [NS39348]; National Institute of Child Health and Human Development [HD040631, HD055269]; Tinnitus Research Consortium FX This study was supported by the National Institutes of Health, National Center for Research Resources Centers of Biomedical Research Excellence (COBRE) grant number RR20146; National Institute of Neurological Disorders and Stroke NS39348; National Institute of Child Health and Human Development HD040631 and HD055269; and by a Tinnitus Research Consortium grant-in-aid. 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[Baer, Susan] British Columbia Childrens Hosp, Dept Psychiat, Vancouver, BC V6H 3V4, Canada. [Lau, Amanda] Univ British Columbia, Dept Med, Vancouver, BC V5Z 1M9, Canada. [Howard, Andrew] British Columbia Neuropsychiat Program, Vancouver, BC, Canada. RP Hadjipavlou, G (reprint author), Univ British Columbia, Dept Psychiat, Vancouver, BC V5Z 1M9, Canada. CR Jastreboff PJ, 2003, OTOLARYNG CLIN N AM, V36, P321, DOI 10.1016/S0030-6665(02)00172-X Jastreboff PJ, 2006, ORL-J OTO-RHIN-LARYN, V68, P23, DOI 10.1159/000090487 NR 2 TC 8 Z9 10 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0033-3174 J9 PSYCHOSOM MED JI Psychosom. Med. 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Res. PD JUL PY 2008 VL 102 IS 1-3 BP 348 EP 351 DI 10.1016/j.schres.2008.04.012 PG 4 WC Psychiatry SC Psychiatry GA 328ZW UT WOS:000257837700043 PM 18501564 ER PT J AU Al-Mana, D Ceranic, B Djahanbakhch, O Luxon, LM AF Al-Mana, D. Ceranic, B. Djahanbakhch, O. Luxon, L. M. TI Hormones and the auditory system: a review of physiology and pathophysiology SO NEUROSCIENCE LA English DT Review DE auditory; hearing; hormones ID BRAIN-STEM RESPONSE; SPONTANEOUS OTOACOUSTIC EMISSIONS; PREMENSTRUAL DYSPHORIC DISORDER; CORTICOTROPIN-RELEASING-FACTOR; SUPERIOR OLIVARY COMPLEX; PITUITARY-ADRENAL AXIS; CENTRAL-NERVOUS-SYSTEM; HUMAN INNER-EAR; IMMUNOREACTIVE BETA-ENDORPHIN; HEARING THRESHOLD LEVELS AB This review explores the potential role of hormones in modulating the auditory function. 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Genovese, E. Marrara, A. Gherpelli, C. Pingani, L. Forghieri, M. Rigatelli, M. Guadagnin, T. Arslan, E. TI Validity of the Italian adaptation of the Tinnitus Handicap Inventory; focus on quality of life and psychological distress in tinnitus-sufferers SO ACTA OTORHINOLARYNGOLOGICA ITALICA LA English DT Article DE Tinnitus; Anxiety; Depression; Quality of life ID DEPRESSION SCALE; HOSPITAL ANXIETY; CONTROLLED TRIAL; HEALTH SURVEY; STIMULATION; RELIABILITY; ABILITY; PROFILE; TESTS; SF-36 AB The aim of this study was to determine the validity of the Italian translation of the Tinnitus Handicap Inventory (THI) by Newman et al. in order to make this self-report measure of perceived tinnitus handicap available both for clinical and research purposes in our country and to contribute to its cross-cultural validation as a self-report measure of perceived severity of tinnitus. The Italian translation of the Tinnitus Handicap Inventory (THI) was administered to 100 outpatients suffering from chronic tinnitus, aged between 20 and 82 years, who attended the audiological tertiary centres of the University Hospital of Modena and the Regional Hospital of Treviso. No segregation of cases was made on audiometric results; patients suffering from vertigo and neurological diseases were excluded. Pyschoacoustic characteristics of tinnitus (loudness and pitch) were determined and all patients also completed the MOS 36-Item Short Form Health Survey to assess self-perceived quality of life and the Hospital Anxiety and Depression Scale as a measure of self-perceived levels of anxiety and depression. The THI-I showed a robust internal consistency reliability (Cronbach's alpha = 0.91) that was only slightly lower than the original version (Tinnitus Handicap Inventory-US; Cronbach's alpha = 0.93) and its Danish (Cronbach's alpha = 0.93) and Portuguese (Cronbach's alpha = 0.94) translations. Also its two subscales (Functional and Emotional) showed a good internal consistency reliability (Cronbach's alpha = 0.85 and 0.86, respectively). On the other hand, the Catastrophic subscale showed an unacceptable internal consistency reliability as it is too short in length (5 items). A confirmatory factor analysis failed to demonstrate that the 3 subscales of the THI-I correspond to 3 different factors. Close correlations were found between the total score of the Italian translation of the Tinnitus Handicap Inventory and all the subscales of the MOS 36-Item Short Form Health Survey (SF-36) and the Hospital Anxiety and Depression Scale scores indicating a good construct validity. Moreover, these statistically significant correlations (p < 0.005) confirmed that the self-report tinnitus handicap is largely related to psychological distress and a deterioration in the quality of life. On the other hand, it was confirmed that the tinnitus perceived handicap is totally independent (p > 0.05) from its audiometrically-derived measures of loudness and pitch thus supporting previous studies that focused on the importance of non-auditory factors, namely somatic attention, psychological distress and coping strategies, in the generation of tinnitus annoyance. Finally the results of the present study suggest that the THI-I maintains its original validity and should be incorporated, together with other adequate psychometric questionnaires, in the audiological examination of patients suffering from tinnitus and that psychiatric counselling should be recommended for the suspected co-morbidity between tinnitus annoyance and psychological distress. C1 [Monzani, D.] Univ Modena & Reggio Emilia, Dept Neurosci Head & Neck Rehabil, Azienda Policlin Univ, I-41100 Modena, Italy. [Monzani, D.; Genovese, E.; Marrara, A.; Gherpelli, C.] Univ Modena & Reggio Emilia, Div Otorhinolaryngol, I-41100 Modena, Italy. [Monzani, D.; Genovese, E.; Marrara, A.; Gherpelli, C.] Univ Modena & Reggio Emilia, Div Psychiat, I-41100 Modena, Italy. [Guadagnin, T.; Arslan, E.] Univ Padua, Ca Foncello Hosp, Div Audiol & Speech Pathol, Treviso, Italy. RP Monzani, D (reprint author), Univ Modena & Reggio Emilia, Dept Neurosci Head & Neck Rehabil, Azienda Policlin Univ, Via Largo Pozzo 71, I-41100 Modena, Italy. 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PD JUN PY 2008 VL 28 IS 3 BP 126 EP 134 PG 9 WC Otorhinolaryngology SC Otorhinolaryngology GA 439PG UT WOS:000265638900004 PM 18646574 ER PT J AU Tyler, RS Haskell, GB Gogel, SA Gehringer, AK AF Tyler, Richard S. Haskell, George B. Gogel, Stephanie A. Gehringer, Anne K. TI Establishing a Tinnitus Clinic in Your Practice SO AMERICAN JOURNAL OF AUDIOLOGY LA English DT Article DE tinnitus; tinnitus clinic; Tinnitus Activities Treatment AB Purpose: While tinnitus is very common among the hearing impaired population, specific treatment for tinnitus is not provided in most clinics. This article provides a plan for establishing a tinnitus treatment program that can be implemented in stages at most audiology clinics. Method: Preparation for establishing a tinnitus clinic includes having an overall plan regarding the type and degree of tinnitus management. Assessment involves a measurement of tinnitus and of the reaction a patient has to the tinnitus, including the use of handicap questionnaires. Management typically involves some form of counseling and sound therapy. Four problematic areas in tinnitus management are thoughts and emotions, hearing and communication, sleep, and concentration. Conclusions: Licensed audiologists generally have the essential training necessary to provide counseling and sound therapy to treat tinnitus patients. We introduce 3 levels of treatment implementation, depending onwhether the patient is curious, concerned, or distressed. Follow-up and referrals might be necessary in more severe cases. Finally, the development of a tinnitus clinic centers around establishing a need for individual treatment, creating a treatment plan, estimating the need for additional staff and resources, reimbursement options, and assessing the effectiveness of the program. C1 [Tyler, Richard S.] Univ Iowa, Dept Otolaryngol, Iowa City, IA 52242 USA. RP Tyler, RS (reprint author), Univ Iowa, Dept Otolaryngol, 200 Hawkins Dr,21167 PFP, Iowa City, IA 52242 USA. EM rich-tyler@uiowa.edu CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT American Speech-Language-Hearing Association, 2004, SCOP PRACT AUD [Anonymous], 2006, PREF PRACT PATT PROF Bartnik G. M., 2006, TINNITUS TREATMENT C, P133 Beck A. T., 1996, MANUAL BECK DEPRESSI BECK AT, 1972, POSTGRAD MED, V52, P81 Bentler R A, 1987, ASHA, V29, P27 BUYSSE DJ, 1989, PSYCHIAT RES, V28, P193, DOI 10.1016/0165-1781(89)90047-4 COLES RRA, 1987, BRIT MED BULL, V43, P983 COX RM, 2005, J AM ACAD AUDIOL, V16, P409 Davis A, 2000, TINNITUS HDB, P1 Davis P. B., 1995, LIVING TINNITUS Davis PB, 2006, TINNITUS TREATMENT C, P146 FLASHER L, 2004, COUNSELING SKILLS SP Folmer R. 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S., 2008, CONSUMER HDB TINNITU Tyler Richard S., 1993, Seminars in Hearing, V14, P377, DOI 10.1055/s-0028-1085135 TYLER R S, 1987, Seminars in Hearing, V8, P49, DOI 10.1055/s-0028-1089904 TYLER RS, 2008, AUDIOLOGICAL MED, V6, P85, DOI 10.1080/16513860801912281 TYLER RS, 1983, J SPEECH HEAR DISORD, V48, P150 Tyler RS, 2006, ORL J OTO-RHINO-LARY, V68, P14, DOI 10.1159/000090486 Vernon J-A, 2000, TINNITUS HDB, P313 Wilson PH, 2000, TINNITUS HDB, P263 Wilson PH, 1998, BRIT J AUDIOL, V32, P273, DOI 10.3109/03005364000000078 WILSON PH, 1991, J SPEECH HEAR RES, V34, P197 WILSON PH, 1993, AUST PSYCHOL, V28, P172, DOI 10.1080/00050069308258898 Zoger S, 2001, AUDIOLOGY, V40, P133 NR 64 TC 6 Z9 6 PU AMER SPEECH-LANGUAGE-HEARING ASSOC PI ROCKVILLE PA 10801 ROCKVILLE PIKE, ROCKVILLE, MD 20852-3279 USA SN 1059-0889 J9 AM J AUDIOL JI Am. J. Audiol. PD JUN PY 2008 VL 17 IS 1 BP 25 EP 37 DI 10.1044/1059-0889(2008/004) PG 13 WC Audiology & Speech-Language Pathology; Otorhinolaryngology SC Audiology & Speech-Language Pathology; Otorhinolaryngology GA V16VI UT WOS:000207896700004 PM 18519577 ER PT J AU Kehrle, HM Granjeiro, RC Sampaio, ALL Bezerra, R Almeida, VF Oliveira, CA AF Kehrle, Helga M. Granjeiro, Ronaldo C. Sampaio, Andre L. L. Bezerra, Roberta Almeida, Vanessa F. Oliveira, Carlos A. TI Comparison of auditory brainstem response results in normal-hearing patients with and without tinnitus SO ARCHIVES OF OTOLARYNGOLOGY-HEAD & NECK SURGERY LA English DT Article ID HIGH-FREQUENCY AUDIOMETRY; EVOKED-RESPONSES; POTENTIALS; LATENCIES; ABR AB Objective: To evaluate electrophysiologically the auditory nerve and the auditory brainstem function of patients with tinnitus and normal-hearing thresholds using the auditory brainstem response (ABR). Design: Case-control study. Setting: Ambulatory section of the Department of Otolaryngology, Hospital de Base de Brasilia. Patients: Thirty-seven individuals with tinnitus and 38 without tinnitus, with ages ranging from 20 to 45 years and pure-tone thresholds of 25 dB or better at frequencies between 500 and 8000 Hz. Main Outcome Measures: We compared the latencies of waves I, II, and V; the interpeak intervals I-III, III-V, and I-V; the interaural latency difference (wave V); and the V/I amplitude ratio between the 2 groups. Results: Among the 37 patients in the study group, abnormal results were found in 16 (43%) in at least 1 of the 8 parameters evaluated. When we analyzed the latencies, although the values were on average in the normal range used in the present study, the tinnitus group presented a significant prolongation of the latencies of waves I, III, and V when compared with the control group. Furthermore, we found the interpeak I-III, III-V, and I-V values to be within the normal limits, but the interpeak III-V value was significantly (P=.003) enlarged in the study group compared with the control group. The V/I amplitude ratio found in the tinnitus group was within normal limits; however, a significant (P=.004) difference was found when the 2 groups were compared. The averages of the interaural latency difference (wave V) did not show significant differences in relation to the control group. Conclusions: We conclude that, although the averages obtained in several analyzed parameters were within normal limits, the ABR results from the patients with and without tinnitus and normal hearing are different, suggesting that ABR might contribute to the workup of these patients. Our data show that there are changes in the central pathways in the study group. The meaning of these changes must be further investigated. C1 [Kehrle, Helga M.; Granjeiro, Ronaldo C.] Hosp Base Brasilia, Dept Otolaryngol, BR-70673431 Brasilia, DF, Brazil. [Sampaio, Andre L. L.; Bezerra, Roberta; Oliveira, Carlos A.] Univ Brasilia, Sch Med, Brasilia, DF, Brazil. [Almeida, Vanessa F.] Hosp Santa Luzia, Clin Otolaryngol, Brasilia, DF, Brazil. RP Kehrle, HM (reprint author), Hosp Base Brasilia, Dept Otolaryngol, SQSW 306,Bloco A,Ap 208, BR-70673431 Brasilia, DF, Brazil. EM helgak1@terra.com.br CR BARNEA G, 1990, AUDIOLOGY, V29, P36 CAHANI M, 1984, AUDIOLOGY, V23, P127 CASSVAN A, 1990, ARCH PHYS MED REHAB, V71, P583 COATS AC, 1977, ARCH OTOLARYNGOL, V103, P605 DOBBIE RA, 1980, AUDITORY PHYS, P14 Hall J. W., 1992, HDB AUDITORY EVOKED, P41 Henry James A, 2002, J Am Acad Audiol, V13, P523 HOOD LJ, 1998, CLIN APPL AUDITORY B, P3 IKNER CL, 1990, EAR HEARING, V11, P16, DOI 10.1097/00003446-199002000-00005 JASTREBOFF PJ, 1990, NEUROSCI RES, V8, P221, DOI 10.1016/0168-0102(90)90031-9 JERGER J, 1970, ARCHIV OTOLARYNGOL, V92, P311 LAUKLI E, 1985, SCAND AUDIOL, V14, P151, DOI 10.3109/01050398509045936 Lemaire MC, 1995, AUDIOLOGY, V34, P287 MAURIZI M, 1985, AUDIOLOGY, V24, P207 MCKEE GJ, 1992, AUDIOLOGY, V31, P313 MOLLER AR, 1982, ELECTROEN CLIN NEURO, V53, P612, DOI 10.1016/0013-4694(82)90137-7 MUSIEK FE, 1982, AM J OTOL, V3, P243 OLIVEIRA CA, 1995, INTER TIN J, V1, P1 ROSENHALL U, 1995, SCAND AUDIOL, V24, P97, DOI 10.3109/01050399509047521 SHULMAN A, 1981, LARYNGOSCOPE, V92, P2025 Silman S, 1997, AUDITORY DIAGNOSIS P, P10 NR 21 TC 12 Z9 13 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610-0946 USA SN 0886-4470 J9 ARCH OTOLARYNGOL JI Arch. Otolaryngol. Head Neck Surg. PD JUN PY 2008 VL 134 IS 6 BP 647 EP 651 DI 10.1001/archotol.134.6.647 PG 5 WC Otorhinolaryngology; Surgery SC Otorhinolaryngology; Surgery GA 312KZ UT WOS:000256671600014 PM 18559734 ER PT J AU Aoki, K Tajima, T Yabushita, Y Nakamura, A Nezu, U Takahashi, M Kimura, M Terauchi, Y AF Aoki, Kazutaka Tajima, Toshihiro Yabushita, Yasuhiro Nakamura, Akinobu Nezu, Uru Takahashi, Mayumi Kimura, Mart Terauchi, Yasuo TI A novel initial codon mutation of the thiazide-sensitive Na-Cl cotransporter gene in a Japanese patient with Gitelman's syndrome SO ENDOCRINE JOURNAL LA English DT Article DE Gitelman's syndrome; TSC gene ID NEUROHYPOPHYSEAL DIABETES-INSIPIDUS; BARTTERS-SYNDROME; HYPOKALEMIC ALKALOSIS; MOLECULAR-CLONING; EXPRESSION; HETEROGENEITY; CHANNEL; FAMILY AB We here report a novel mutation of the thiazide-sensitive Na-Cl cotransporter (TSC) (SLC12A3) gene in a Japanese patient with Gitelman's syndrome (GS). GS is characterized by a renal disorder and is associated with hypokalemia, hypomagnesemia, metabolic alkalosis and hypocalciuria arising from the defective tubular reabsorption of magnesium and potassium. This disease is reportedly caused by mutations in the TSC gene. A 52-year-old man was referred to our hospital because of sleeplessness and tinnitus. He exhibited hypokalemia, hypomagnesemia, hypocalciuria, metabolic alkalosis and hyperreninemic hyperaldosteronism. A renal clearance study revealed that the administration of furosemide decreased chloride reabsorption; however, the ingestion of thiazide failed to decrease chloride reabsorption. A diagnosis of GS was made based on the clinical features, laboratory data and renal function test results. Sequencing of the patient's genomic DNA revealed an A to T transition at the initial codon of exon 1 of the TSC gene (c1A > T). Knowledge of this novel mutation may be helpful for understanding the pathophysiology of GS and the function of TSC as well as for providing genetic counseling. C1 [Aoki, Kazutaka; Yabushita, Yasuhiro; Nakamura, Akinobu; Nezu, Uru; Takahashi, Mayumi; Kimura, Mart; Terauchi, Yasuo] Yokohama City Univ, Dept Endocrinol & Metab, Grad Sch Med, Kanazawa Ku, Yokohama, Kanagawa 2360004, Japan. [Tajima, Toshihiro] Hokkaido Univ, Sch Med, Dept Pediat, Sapporo, Hokkaido 060, Japan. RP Terauchi, Y (reprint author), Yokohama City Univ, Dept Endocrinol & Metab, Grad Sch Med, Kanazawa Ku, 3-9 Fuku Ura, Yokohama, Kanagawa 2360004, Japan. RI Toshihiro, Tajima/A-5720-2012 CR BETTINELLI A, 1992, J PEDIATR-US, V120, P38, DOI 10.1016/S0022-3476(05)80594-3 BETTINELLI A, 1995, KIDNEY INT, V47, P547, DOI 10.1038/ki.1995.68 Christensen JH, 2004, EUR J HUM GENET, V12, P44, DOI 10.1038/sj.ejhg.5201086 De Jong JC, 2002, J AM SOC NEPHROL, V13, DOI 10.1097/01.ASN.0000017904.77985.03 GAMBA G, 1994, J BIOL CHEM, V269, P17713 Graham J, 1966, T ASSOC AM PHYSICIAN, V79, P92 Hashida T, 2006, ENDOCR J, V53, P859, DOI 10.1507/endocrj.K06-076 Knoers NVAM, 2006, ADV CHRONIC KIDNEY D, V13, P148, DOI 10.1053/j.ackd.2006.01.014 Kunchaparty S, 1999, AM J PHYSIOL-RENAL, V277, pF643 LIDA K, 2004, CLIN NEPHROL, V62, P180 Mastroianni N, 1996, AM J HUM GENET, V59, P1019 Mastroianni N, 1996, GENOMICS, V35, P486, DOI 10.1006/geno.1996.0388 Obermuller N, 1995, AM J PHYSIOL-RENAL, V269, pF900 Rutishauser J, 1996, J CLIN ENDOCR METAB, V81, P192, DOI 10.1210/jc.81.1.192 Simon DB, 1996, NAT GENET, V13, P183, DOI 10.1038/ng0696-183 Simon DB, 1996, NAT GENET, V14, P152, DOI 10.1038/ng1096-152 Simon DB, 1997, NAT GENET, V17, P171, DOI 10.1038/ng1097-171 Simon DB, 1996, NAT GENET, V12, P24, DOI 10.1038/ng0196-24 Tajima T, 2002, ENDOCR J, V49, P91, DOI 10.1507/endocrj.49.91 Terui K, 2006, CLIN NEPHROL, V65, P57 TSUKAMOTO T, 1995, AM J KIDNEY DIS, V25, P637, DOI 10.1016/0272-6386(95)90137-X NR 21 TC 7 Z9 8 PU JAPAN ENDOCRINE SOC PI KYOTO PA 75 YANAGINOBANBA NISHIIRU-MASUYA-CHO, SANJOU-DORI, NAKAGYOU-KU, KYOTO, 604-8111, JAPAN SN 0918-8959 EI 1348-4540 J9 ENDOCR J JI Endocr. J. PD JUN PY 2008 VL 55 IS 3 BP 557 EP 560 DI 10.1507/endocrj.K07E-113 PG 4 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA 321YU UT WOS:000257343200017 PM 18520105 ER PT J AU Davis, PB Wilde, RA Steed, LG Hanley, PJ AF Davis, Paul B. Wilde, Ron A. Steed, Lyndall G. Hanley, Peter J. TI Treatment of tinnitus with a customized acoustic neural stimulus: A controlled clinical study SO ENT-EAR NOSE & THROAT JOURNAL LA English DT Article ID MANAGEMENT AB In patients with tinnitus, achieving consistently positive treatment results is a challenge. We conducted a controlled clinical study of a new treatment approach (Neuromonics Tinnitus Treatment) that involves the use of a customized neural stimulus. This stimulus is delivered to the patient in the form of a pleasant acoustic sensation that is spectrally modified according to each patient's individual audiometric profile. This treatment approach is provided as part of a structured rehabilitation program. In our study, patients who received the customized stimulus (Neuromonics group) reported significantly greater and more consistent alleviation of tinnitus symptoms than did patients who participated in a counseling and support program with and without delivery of a broadband noise stimulus (Noise + Counseling group and Counseling-Only group, respectively). After 6 months of treatment, 86% of the Neuromonics patients met the minimum criterion for clinical success, defined as an alleviation of tinnitus disturbance of at least 40% (as determined by the Tinnitus Reaction Questionnaire score). By contrast, only 47 and 23% of the Noise + Counseling and Counseling-Only groups, respectively, reported a successful result according to this criterion. Mean improvements in tinnitus disturbance scores in the Neuromonics, Noise + Counseling, and Counseling-Only groups were 66,22, and 15%, respectively. The differences between the Neuromonics group and the control groups were statistically significant. Significant differences were observed in other clinical outcomes. Patient reports Of user acceptability were more consistently positive in the Neuromonics group. C1 [Davis, Paul B.; Wilde, Ron A.] Curtin Univ Technol, Div Hlth Sci, Perth, WA, Australia. [Steed, Lyndall G.] Curtin Univ Technol, Sch Psychol, Perth, WA, Australia. [Hanley, Peter J.] Neuromon Pty Ltd, Sydney, NSW, Australia. RP Davis, PB (reprint author), Nova SE Univ, Dept Audiol, 3200 S Univ Dr, Ft Lauderdale, FL 33328 USA. EM pauldavi@nova.edu CR BAGULEY DM, 2003, HYPERACUSIS MECH DIA COLES RRA, 1995, TINNITUS RETRAINING COLES RRA, 1991, P 4 INT TINN SEM AMS, P563 Davis P, 1999, P 6 INT TINN SEM LON, P384 Davis P. 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PD JUN PY 2008 VL 87 IS 6 BP 330 EP + PG 9 WC Otorhinolaryngology SC Otorhinolaryngology GA 318LK UT WOS:000257093000010 PM 18561116 ER PT J AU Basta, D Goetze, R Ernst, A AF Basta, Dietmar Goetze, Romy Ernst, Arne TI Effects of salicylate application on the spontaneous activity in brain slices of the mouse cochlear nucleus, medial geniculate body and primary auditory cortex SO HEARING RESEARCH LA English DT Article DE tinnitus; sodium salicylate; cochlear nucleus; medial geniculate body; auditory cortex; spontaneous activity; brain slice ID INFERIOR COLLICULUS NEURONS; SODIUM-SALICYLATE; GUINEA-PIG; ANIMAL-MODEL; SPINAL-CORD; RATS; TINNITUS; OTOTOXICITY; CAT; EXPRESSION AB Salicylate is a well-known substance to produce reversible tinnitus in animals and humans as well. It has been shown that systemic application of salicylate changes the neuronal spontaneous activity in several parts of the auditory pathway. The effects observed in central auditory structures in vivo could be based upon the changed afferent cochlear input to the central auditory system or in addition by a direct action of salicylate onto neurons within the auditory pathway. A direct influence of local salicylate application on spontaneous activity of central auditory neurons has already been described for the inferior colliculus (IC) in brain slice preparations. As spontaneous activity within all key structures of the central auditory pathway could play an important role in tinnitus generation, the present study investigated direct effects of salicylate superfusion on the spontaneous activity of the deafferented cochlear nucleus (CN), medial geniculate body (MGB), and auditory cortex (AC) in brain slices. Out of 72 neurons, 73.4% responded statistically significantly to the superfusate by changing their firing rates. 48.4% of them increased and 51.6% decreased their firing rates, respectively. The mean change of firing rate upon salicylate superfusion was 24.4%. All responses were not significantly different between the brain areas. The amount of neurons which responded to salicylate and the mean change of firing rate was much higher in the IC than in the CN, MGB and AC. This contributes to the hypothesis that salicylate-induced tinnitus is a phantom auditory perception mainly related to hyperexcitability of IC neurons. However, the present results suggest that the individual, specific salicylate sensitivity of CN, MGB and AC neurons can modulate the salicylate-induced generation of tinnitus. (C) 2008 Elsevier B.V. All rights reserved. C1 [Basta, Dietmar; Ernst, Arne] Univ Berlin, Charite Med Sch, Dept Otolaryngol, UKB, D-12683 Berlin, Germany. [Basta, Dietmar; Goetze, Romy] Humboldt Univ, Inst Biol, D-10115 Berlin, Germany. RP Basta, D (reprint author), Univ Berlin, Charite Med Sch, Dept Otolaryngol, UKB, Warener Str 7, D-12683 Berlin, Germany. 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Res. PD JUN PY 2008 VL 240 IS 1-2 BP 42 EP 51 DI 10.1016/j.heares.2008.02.005 PG 10 WC Audiology & Speech-Language Pathology; Neurosciences; Otorhinolaryngology SC Audiology & Speech-Language Pathology; Neurosciences & Neurology; Otorhinolaryngology GA 324PW UT WOS:000257531500004 PM 18372130 ER PT J AU Schaette, R Kempter, R AF Schaette, Roland Kempter, Richard TI Development of hyperactivity after hearing loss in a computational model of the dorsal cochlear nucleus depends on neuron response type SO HEARING RESEARCH LA English DT Article DE dorsal cochlear nucleus; computational model; hearing loss; hyperactivity; auditory nerve; homeostatic plasticity ID HAIR CELL LOSS; ENRICHED ACOUSTIC ENVIRONMENT; DEAFNESS ASSOCIATED CHANGES; DOMAIN POTASSIUM CHANNELS; STEM AUDITORY NUCLEI; INFERIOR COLLICULUS; INTENSE SOUND; BRAIN-STEM; GUINEA-PIG; HOMEOSTATIC PLASTICITY AB Cochlear damage can change the spontaneous firing rates of neurons in the dorsal cochlear nucleus (DCN). Increased spontaneous firing rates (hyperactivity) after acoustic trauma have been observed in the DCN of rodents such as hamsters, chinchillas and rats. This hyperactivity has been interpreted as a neural correlate of tinnitus. In cats, however, the spontaneous firing rates of DCN neurons were not significantly elevated after acoustic trauma. Species-specific spontaneous firing rates after cochlear damage might be attributable to differences in the response types of DCN neurons: In gerbils, type III response characteristics are predominant, whereas in cats type IV responses are more frequent. To address the question of how the development of hyperactivity after cochlear damage depends on the response type of DCN neurons, we use a computational model of the basic circuit of the DCN. By changing the strength of two types of inhibition, we can reproduce salient features of the responses of DCN neurons. Simulated cochlear damage, which decreases the activity of auditory nerve fibers, is assumed to activate homeostatic plasticity in projection neurons (PNs) of the DCN. We find that the resulting spontaneous firing rates depend on the response type of DCN PNs: PNs with type III and type IV-T response characteristics may become hyperactive, whereas type IV PNs do not develop increased spontaneous firing rates after acoustic trauma. This theoretical framework for the mechanisms and circumstances of the development of hyperactivity in central auditory neurons might also provide new insights into the development of tinnitus. (C) 2008 Elsevier B.V. All rights reserved. C1 [Schaette, Roland; Kempter, Richard] Humboldt Univ, Dept Biol, Inst Theoret Biol, D-10115 Berlin, Germany. [Schaette, Roland; Kempter, Richard] Bernstein Ctr Computat Neurosci Berlin, D-10115 Berlin, Germany. [Schaette, Roland; Kempter, Richard] Charite Univ Med Berlin, Neurosci Res Ctr, D-10117 Berlin, Germany. RP Schaette, R (reprint author), Humboldt Univ, Dept Biol, Inst Theoret Biol, Invalidenstr 43, D-10115 Berlin, Germany. 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Res. PD JUN PY 2008 VL 240 IS 1-2 BP 57 EP 72 DI 10.1016/j.heares.2008.02.006 PG 16 WC Audiology & Speech-Language Pathology; Neurosciences; Otorhinolaryngology SC Audiology & Speech-Language Pathology; Neurosciences & Neurology; Otorhinolaryngology GA 324PW UT WOS:000257531500006 PM 18396381 ER PT J AU Georgiewa, P Rothemund, Y Bohner, G Bauknecht, C Mazurek, B Klingebiel, R Klapp, BF AF Georgiewa, Petra Rothemund, Yvonne Bohner, Georg Bauknecht, Christian Mazurek, Birgit Klingebiel, Randolf Klapp, Burghard F. TI fMRI during affective processing in tinnitus patients and normal controls SO INTERNATIONAL JOURNAL OF PSYCHOLOGY LA English DT Meeting Abstract C1 [Georgiewa, Petra; Rothemund, Yvonne; Klapp, Burghard F.] Charite Univ Med Berlin, Klin Psychosomat, D-13353 Berlin, Germany. [Bohner, Georg; Bauknecht, Christian; Klingebiel, Randolf] Charite Univ Med Berlin, Klin Neuroradiol, D-13353 Berlin, Germany. [Mazurek, Birgit] Charite Univ Med Berlin, Tinnituszentrum, D-13353 Berlin, Germany. NR 0 TC 0 Z9 0 PU PSYCHOLOGY PRESS PI HOVE PA 27 CHURCH RD, HOVE BN3 2FA, EAST SUSSEX, ENGLAND SN 0020-7594 J9 INT J PSYCHOL JI Int. J. Psychol. PD JUN-AUG PY 2008 VL 43 IS 3-4 BP 311 EP 312 PG 2 WC Psychology, Multidisciplinary SC Psychology GA 349EO UT WOS:000259264303612 ER PT J AU Stege, U Joachim, R Stege, K Kischkel, E Mazurek, B Reisshauer, A AF Stege, Uta Joachim, Ricarda Stege, Kathrin Kischkel, Eva Mazurek, Birgit Reisshauer, Anett TI Psychological comorbidity and coping strategies in patients with chronic tinnitus SO INTERNATIONAL JOURNAL OF PSYCHOLOGY LA English DT Meeting Abstract C1 [Stege, Uta] Charite Berlin Phys, Med & Rehabil, Berlin, Germany. [Joachim, Ricarda; Stege, Kathrin; Reisshauer, Anett] Univ Berlin, CC Internal Med 12, Berlin, Germany. [Kischkel, Eva] Humboldt Univ, CC Internal Med 12, Berlin, Germany. [Mazurek, Birgit] Univ Med Berlin, CC Otorhinolaryngol 16, Berlin, Germany. NR 0 TC 0 Z9 0 PU PSYCHOLOGY PRESS PI HOVE PA 27 CHURCH RD, HOVE BN3 2FA, EAST SUSSEX, ENGLAND SN 0020-7594 J9 INT J PSYCHOL JI Int. J. Psychol. PD JUN-AUG PY 2008 VL 43 IS 3-4 BP 476 EP 476 PG 1 WC Psychology, Multidisciplinary SC Psychology GA 349EO UT WOS:000259264305558 ER PT J AU Heinecke, K Weise, C Schwarz, K Rief, W AF Heinecke, Kristin Weise, Cornelia Schwarz, Kristin Rief, Winfried TI Physiological and psychological stress reactivity in chronic tinnitus SO JOURNAL OF BEHAVIORAL MEDICINE LA English DT Article DE chronic tinnitus; stress reactivity; EMG; biofeedback; psychophysiology ID CHRONIC PAIN PATIENTS; EMOTIONAL DISTRESS; COMPLEX TINNITUS; SEVERITY; SUFFERERS; MUSCLE; MODEL; LIFE AB Several models of tinnitus maintenance emphasize the importance of cognitive, emotional and psychophysiological processes. These factors contribute to distress in patients with decompensated tinnitus symptoms. We investigated whether tinnitus patients show increased physiological levels of arousal, more intense stress reactivity patterns and exaggerated psychological strain compared to healthy controls. Seventy tinnitus patients and 55 healthy controls underwent various stress tests. Muscular reactivity and peripheral arousal as well as strain ratings were assessed. Tinnitus patients reported significantly more strain during stress tests compared to healthy controls. Few physiological reactivity patterns differed significantly between the two groups. The physiological data thus only partly supported a hyperreactivity hypothesis. Strain reports and physiological data were only marginally correlated. Tinnitus patients show maladaptive appraisal processes during stress exposure, yet physiological reactivity is only slightly affected. Treatment programs for patients with decompensated tinnitus symptoms should account for appraisal processes and coping mechanisms in stressful situations. 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Behav. Med. PD JUN PY 2008 VL 31 IS 3 BP 179 EP 188 DI 10.1007/s10865-007-9145-0 PG 10 WC Psychology, Clinical SC Psychology GA 304DK UT WOS:000256090000001 PM 18193350 ER PT J AU Wienke, A Janke, K AF Wienke, A. Janke, K. TI Necessity of inpatient treatment in case of chronic tinnitus and mental damage due to the course of disease SO LARYNGO-RHINO-OTOLOGIE LA German DT Editorial Material C1 [Wienke, A.; Janke, K.] Wienke & Becker Koln, D-50968 Cologne, Germany. RP Wienke, A (reprint author), Wienke & Becker Koln, Bonner Str 323, D-50968 Cologne, Germany. EM AWienke@Kanzlei-WBK.de NR 0 TC 0 Z9 0 PU GEORG THIEME VERLAG KG PI STUTTGART PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY SN 0935-8943 J9 LARYNGO RHINO OTOL JI Laryngo-Rhino-Otol. PD JUN PY 2008 VL 87 IS 6 BP 423 EP 424 DI 10.1055/s-2007-995447 PG 2 WC Otorhinolaryngology SC Otorhinolaryngology GA 311EJ UT WOS:000256583200013 PM 18506654 ER PT J AU Kopell, BH Raghavan, M Gaggl, W Runge-Samuelson, C Hulvershorn, J Soltysik, D Friedland, D AF Kopell, Brian H. Raghavan, Manoj Gaggl, Wolfgang Runge-Samuelson, Christina Hulvershorn, Justin Soltysik, David Friedland, David TI Cortical stimulation for tinnitus: Long-term follow-up with PET/rTMS SO NEUROSURGERY LA English DT Meeting Abstract CT Annual Scientific Meeting of Neurological Surgeons CY SEP 20-25, 2008 CL Orlando, FL SP Orange County Convent Ctr NR 0 TC 0 Z9 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0148-396X J9 NEUROSURGERY JI Neurosurgery PD JUN PY 2008 VL 62 IS 6 MA 858 BP 1419 EP 1419 PG 1 WC Clinical Neurology; Surgery SC Neurosciences & Neurology; Surgery GA 334MS UT WOS:000258226500104 ER PT J AU Cvorovic, L Deric, D Probst, R Hegemann, S AF Cvorovic, Ljiljana Deric, Dragoslava Probst, Rudolf Hegemann, Stefan TI Prognostic model for predicting hearing recovery in idiopathic sudden sensorineural hearing loss SO OTOLOGY & NEUROTOLOGY LA English DT Article DE idiopathic sudden sensorineural hearing loss; prognostic model; recovery ID DOUBLE-BLIND; DEAFNESS; EXPERIENCE AB Hypothesis: To aid in realistic counseling of patients at the time of their first visit concerning their chances for recovery, we created a simple prognostic model for predicting hearing recovery in idiopathic sudden sensorineural hearing loss (ISSHL). Background: An important element of research on ISSHL is to identify prognostic factors for this disease. Many studies have described predictive indicators to identify patients with a good prognosis needing no or minimal treatment. Only a few of these studies have included a model for calculating the probability for patient recovery, which may be important for clinical work, but these prognostic tables have not achieved widespread use clinically. Methods: Evaluation of an electronic patient data base of 541 patients with ISSHL. The standard treatment was carbogen inhalation (95% O-2 and 5% CO2 8 times per day in duration of 30 min) and prednisone orally (100 mg in 1 morning dose) for 7 days. Factors that were analyzed included the patient's age, the interval between the onset of symptoms and beginning of treatment, the presence or absence of vertigo and tinnitus, audiometric patterns, the severity of hearing loss, and hearing in the opposite ear. Hearing gain was expressed either as absolute hearing gain or as relative hearing gain. Significant recovery of hearing was defined as the final pure-tone audiometry of 30 dB or less (or the same as the pure-tone audiometry of the opposite car). Results: The absolute hearing gain was 15.1 dB. The mean relative hearing gain was 47%. Three hundred one (57%) patients had significant recovery of hearing, and 228 (43%) did not have significant recovery of hearing. Using step-wise multiple linear regression analysis, the most important factors for prognosis included severity of hearing loss, presence of vertigo, time between onset and treatment, the hearing of the other ear, and the audiogram shape (beta coefficient was -0.216, -0.231, 0.211, 0.113, and -0.064, respectively; constant, 0.968). A recovery expectancy table was developed using the data from this study. Conclusion: Based on a retrospective analysis, prognostic indicators for hearing recovery in ISSHL were found to be severity of hearing loss, presence of vertigo, time between onset and treatment, the hearing of the other ear, and the audiogram shape. We created a model for calculating the probability for hearing recovery based on the analysis of 529 patients with unilateral ISSHL. C1 [Cvorovic, Ljiljana] Univ Hosp Zemun, Dept Otorhinolaryngol, Belgrade 11080, Serbia. [Deric, Dragoslava] Clin Ctr Serbia, Inst Otorhinolaryngol, Belgrade, Serbia. [Probst, Rudolf; Hegemann, Stefan] Univ Zurich Hosp, Dept Otorhinolaryngol, CH-8091 Zurich, Switzerland. RP Cvorovic, L (reprint author), Univ Hosp Zemun, Dept Otorhinolaryngol, Vukova 9, Belgrade 11080, Serbia. EM ljiljanamil@sezampro.yu RI Hegemann, Stefan/B-4640-2013 OI Hegemann, Stefan/0000-0002-9464-352X CR Ben-David J, 2001, Int Tinnitus J, V7, P62 BYL FM, 1984, LARYNGOSCOPE, V94, P647 Chang NC, 2005, OTOLARYNG HEAD NECK, V133, P916, DOI 10.1016/j.otohns.2005.09.018 Fetterman BL, 1996, AM J OTOL, V17, P529 Huy PTB, 2005, OTOL NEUROTOL, V26, P896, DOI 10.1097/01.mao.0000185071.35328.6d Huy PTB, 1999, OTO RHINO LARYN NOVA, V9, P171 LAIRD N, 1983, AM J OTOLARYNG, V4, P161, DOI 10.1016/S0196-0709(83)80038-6 Linssen O, 1997, HNO, V45, P22, DOI 10.1007/s001060050083 MATTOX DE, 1989, AM J OTOL, V10, P242 MATTOX DE, 1977, ANN OTO RHINOL LARYN, V86, P463 Mazzoli M., 2003, AUDIOL MED, V1, P148, DOI 10.1080/16513860301713 NAKASHIMA T, 1993, LARYNGOSCOPE, V103, P1145 Narozny W, 2006, ANN OTO RHINOL LARYN, V115, P553 PROBST R, 1992, ACTA OTO-LARYNGOL, V112, P435, DOI 10.3109/00016489209137424 Sano H, 1998, AM J OTOL, V19, P579 SHAIA FT, 1976, LARYNGOSCOPE, V86, P389, DOI 10.1288/00005537-197603000-00008 Stokroos RJ, 1998, ACTA OTO-LARYNGOL, V118, P488, DOI 10.1080/00016489850154603 Tabuchi K, 1999, ACTA OTO-LARYNGOL, V119, P179 Tran Ba Huy P., 2007, ANN OTOLARYNGOL CHIR, V124, P66 Weinaug P, 2001, HNO, V49, P431, DOI 10.1007/s001060170090 WILSON WR, 1993, OTOLARYNGOLOGY HEAD, V3, P103 WILSON WR, 1980, ARCH OTOLARYNGOL, V106, P772 NR 22 TC 36 Z9 38 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1531-7129 J9 OTOL NEUROTOL JI Otol. Neurotol. PD JUN PY 2008 VL 29 IS 4 BP 464 EP 469 PG 6 WC Clinical Neurology; Otorhinolaryngology SC Neurosciences & Neurology; Otorhinolaryngology GA 307PT UT WOS:000256331500007 PM 18434930 ER PT J AU De Ridder, D Menovsky, T van de Heyning, P AF De Ridder, Dirk Menovsky, Tomas van de Heyning, Paul TI Auditory cortex stimulation for tinnitus suppression SO OTOLOGY & NEUROTOLOGY LA English DT Letter ID TRANSCRANIAL MAGNETIC STIMULATION; INTRACTABLE TINNITUS C1 [De Ridder, Dirk; Menovsky, Tomas; van de Heyning, Paul] Univ Antwerp Hosp, Tinnitus Clin Antwerp, Multidiscplinary TRI, Edegem, Belgium. RP De Ridder, D (reprint author), Univ Antwerp Hosp, Tinnitus Clin Antwerp, Multidiscplinary TRI, Edegem, Belgium. CR De Ridder D, 2005, OTOL NEUROTOL, V26, P616, DOI 10.1097/01.mao.0000178146.91139.3c De Ridder D, 2006, ORL J OTO-RHINO-LARY, V68, P54 De Ridder D, 2006, ORL J OTO-RHINO-LARY, V68, P48, DOI 10.1159/000090491 De Ridder D, 2004, J NEUROSURG, V100, P560, DOI 10.3171/jns.2004.100.3.0560 Kleinjung T, 2007, PROG BRAIN RES, V166, P359, DOI 10.1016/S0079-6123(07)66034-8 Londero A, 2006, NEUROPHYSIOL CLIN, V36, P145, DOI 10.1016/j.neucli.2006.08.001 NR 6 TC 5 Z9 5 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1531-7129 J9 OTOL NEUROTOL JI Otol. Neurotol. PD JUN PY 2008 VL 29 IS 4 BP 574 EP 575 DI 10.1097/MAO.0b013e3181719773 PG 2 WC Clinical Neurology; Otorhinolaryngology SC Neurosciences & Neurology; Otorhinolaryngology GA 307PT UT WOS:000256331500034 PM 18418286 ER PT J AU Friedland, DR Kopell, BH AF Friedland, David R. Kopell, Brian Harris TI Feasibility of auditory cortical stimulation for the treatment of tinnitus: In reply SO OTOLOGY & NEUROTOLOGY LA English DT Letter C1 [Friedland, David R.] Med Coll Wisconsin, Dept Otolaryngol & Commun Sci, Milwaukee, WI 53226 USA. [Kopell, Brian Harris] Med Coll Wisconsin, Dept Neurosurg, Milwaukee, WI 53226 USA. Clement J Zablocki VA Med Ctr, Milwaukee, WI USA. RP Friedland, DR (reprint author), Med Coll Wisconsin, Dept Otolaryngol & Commun Sci, Milwaukee, WI 53226 USA. CR De Ridder D, 2007, NEW ENGL J MED, V357, P1829, DOI 10.1056/NEJMoa070010 De Ridder D, 2006, ORL J OTO-RHINO-LARY, V68, P48, DOI 10.1159/000090491 KOPELL BH, 2007, INT NEUR SOC M AC ME Plewnia C, 2007, PROG NEURO-PSYCHOPH, V31, P301, DOI 10.1016/j.pnpbp.2006.08.014 SEIDMAN MD, 2007, LARYNGOSCOPE, V118, P491 NR 5 TC 0 Z9 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1531-7129 J9 OTOL NEUROTOL JI Otol. Neurotol. PD JUN PY 2008 VL 29 IS 4 BP 575 EP 575 DI 10.1097/MAO.0b013e3181719786 PG 1 WC Clinical Neurology; Otorhinolaryngology SC Neurosciences & Neurology; Otorhinolaryngology GA 307PT UT WOS:000256331500035 ER PT J AU Hinton, DE Hinton, SD Loeum, RJR Pich, V Pollack, MH AF Hinton, Devon E. Hinton, Susan D. Loeum, Reattidara J. -R. Pich, Vuth Pollack, Mark H. TI The 'Multiplex Model' of Somatic Symptoms: Application to Tinnitus among Traumatized Cambodian Refugees SO TRANSCULTURAL PSYCHIATRY LA English DT Article DE anxiety; Cambodian refugees; catastrophic cognitions; posttraumatic stress disorder; somatization; tinnitus ID PANIC DISORDER; DISTRESS; THERAPY; PTSD; SEVERITY; ANXIETY; ATTACKS; STRESS AB Somatic symptoms are a common clinical presentation of distress among ethnic populations in the USA, particularly traumatized refugees. In this article, we apply a 'multiplex model' of bodily experience to explain how a somatic symptom is evoked, amplified, and generates distress, particularly distress related to post-traumatic stress disorder. We illustrate the multiplex model's applicability to acute episodes of tinnitus (i.e., a buzzing-like sound in the ear) among Cambodian refugees, a common symptom in that group. The article demonstrates the importance of carefully examining somatic symptoms and associated meanings in distressed ethnic populations, especially traumatized refugees, and aims to contribute to a medical anthropology of somatic symptoms. C1 [Loeum, Reattidara J. -R.; Pich, Vuth] Arbour Counseling Serv, SE Asian Clin, Lowell, MA 01852 USA. [Pich, Vuth] Massachusetts Dept Mental Hlth, Medfield, MA 02052 USA. [Pollack, Mark H.] Massachusetts Gen Hosp, Anxiety Disorders Program, Boston, MA 02114 USA. [Hinton, Devon E.; Hinton, Susan D.; Pollack, Mark H.] Harvard Univ, Sch Med, Cambridge, MA 02138 USA. RP Hinton, DE (reprint author), Arbour Counseling Serv, SE Asian Clin, Lowell, MA 01852 USA. EM devon_hinton@hms.harvard.edu CR ALPINI D, 2006, ORL, V22, P31 Andersson G, 2002, CLIN PSYCHOL REV, V22, P977, DOI 10.1016/S0272-7358(01)00124-6 ANDERSSON G, 2006, ACTA OTO-LARYNGOL, V556, P39 Cacace AT, 2003, HEARING RES, V175, P112, DOI 10.1016/S0378-5955(02)00717-7 CASPI Y, 1998, J NERV MENT DIS, V186, P485 CHUNG RCY, 1995, J NERV MENT DIS, V183, P639, DOI 10.1097/00005053-199510000-00005 CLARK DM, 1986, BEHAV RES THER, V24, P461, DOI 10.1016/0005-7967(86)90011-2 Damasio A., 2003, LOOKING SPINOZA JOY Damasio Antonio, 1994, DESCARTES ERROR EMOT FOA EB, 1986, PSYCHOL BULL, V99, P20, DOI 10.1037//0033-2909.99.1.20 Foa EB, 1998, BEHAV THER, V29, P675, DOI 10.1016/S0005-7894(98)80025-7 Henry J. 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J., 1996, ETHNOCULTURAL ASPECT, P131, DOI DOI 10.1037/10555-005 Kirmayer LJ, 1984, TRANSCULT PSYCHIATRY, V21, P159, DOI 10.1177/136346158402100301 LEWIS IM, 2002, ECSTATIC RELIG Lin KM, 1999, PSYCHIATR SERV, V50, P774 NICHTER M, 1981, CULT MED PSYCHIAT, V5, P379, DOI 10.1007/BF00054782 Nuckolls Janis, 2004, HEARING CULTURES ESS, P65 ROSEMAN M, 1990, ETHOS, V18, P227, DOI 10.1525/eth.1990.18.3.02a00010 Roseman Marina, 1991, HEALING SOUNDS MALAY ROSEN J, 1998, PSYCHOL REV, V2, P325 Van der Does AJW, 2000, BEHAV RES THER, V38, P47, DOI 10.1016/S0005-7967(98)00184-3 Voeltz FKE, 2001, IDEOPHONES WHITE GM, 1982, SOC SCI MED, V16, P1519, DOI 10.1016/0277-9536(82)90067-3 Wilson PH, 2006, ORL J OTO-RHINO-LARY, V68, P6, DOI 10.1159/000090485 Zenner HP, 2004, ACTA OTO-LARYNGOL, V124, P436, DOI 10.1080/00016480410016333 NR 42 TC 9 Z9 9 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 1363-4615 J9 TRANSCULT PSYCHIATRY JI Transcult. Psychiatry PD JUN PY 2008 VL 45 IS 2 BP 287 EP 317 DI 10.1177/1363461508089768 PG 31 WC Anthropology; Psychiatry SC Anthropology; Psychiatry GA 369QT UT WOS:000260709700007 PM 18562496 ER PT J AU El Dib, RP Silva, EMK Morais, JF Trevisani, VFM AF El Dib, Regina P. Silva, Edina M. K. Morais, Jose F. Trevisani, Virginia F. M. TI Prevalence of high frequency hearing loss consistent with noise exposure among people working with sound systems and general population in Brazil: A cross-sectional study SO BMC PUBLIC HEALTH LA English DT Article ID MUSICIANS; PROTECTION; WORKERS; ENVIRONMENTS AB Background: Music is ever present in our daily lives, establishing a link between humans and the arts through the senses and pleasure. Sound technicians are the link between musicians and audiences or consumers. Recently, general concern has arisen regarding occurrences of hearing loss induced by noise from excessively amplified sound-producing activities within leisure and professional environments. Sound technicians' activities expose them to the risk of hearing loss, and consequently put at risk their quality of life, the quality of the musical product and consumers' hearing. The aim of this study was to measure the prevalence of high frequency hearing loss consistent with noise exposure among sound technicians in Brazil and compare this with a control group without occupational noise exposure. Methods: This was a cross-sectional study comparing 177 participants in two groups: 82 sound technicians and 95 controls (non-sound technicians). A questionnaire on music listening habits and associated complaints was applied, and data were gathered regarding the professionals' numbers of working hours per day and both groups' hearing complaint and presence of tinnitus. The participants' ear canals were visually inspected using an otoscope. Hearing assessments were performed (tonal and speech audiometry) using a portable digital AD 229 E audiometer funded by FAPESP. Results: There was no statistically significant difference between the sound technicians and controls regarding age and gender. Thus, the study sample was homogenous and would be unlikely to lead to bias in the results. A statistically significant difference in hearing loss was observed between the groups: 50% among the sound technicians and 10.5% among the controls. The difference could be addressed to high sound levels. Conclusion: The sound technicians presented a higher prevalence of high frequency hearing loss consistent with noise exposure than did the general population, although the possibility of residual confounding due to unmeasured factors such as socioeconomic status cannot be ruled out. C1 [El Dib, Regina P.; Silva, Edina M. K.; Trevisani, Virginia F. M.] Univ Fed Sao Paulo, Brazilian Cochrane Ctr, Urgency Med & Evidence Based Med Dept, Sao Paulo, Brazil. [Morais, Jose F.] Pontificial Catholic Univ Sao Paulo, Actuary & Quantitat Methods Dept, Sao Paulo, Brazil. RP El Dib, RP (reprint author), Univ Fed Sao Paulo, Brazilian Cochrane Ctr, Urgency Med & Evidence Based Med Dept, Sao Paulo, Brazil. EM re.lucci@terra.com.br; edinaksilva@terra.com.br; jfmorais@pucsp.br; vmoca@uol.com.br RI de Morais, Jose Fausto/E-9651-2010; Legarth, Jonas/A-9156-2012; trevisani, Virginia/I-1137-2013; Trevisani, Virginia/B-4423-2015 OI trevisani, Virginia/0000-0002-7180-6285; CR *ACGIH, 2007, GUID OCC EXP VAL ALMEIDA ER, 2004, CADERNO DEBATES RBOR, V70, P56 ANDRADE AIA, 2000, REV BRAS OTORRINOLAR, V68 Arezes PM, 2002, ANN OCCUP HYG, V46, P531, DOI 10.1093/annhyg/mef067 AXELSSON A, 1981, EAR HEARING, V2, P64, DOI 10.1097/00003446-198103000-00002 AXELSSON A, 1977, Scandinavian Audiology, V6, P127, DOI 10.3109/01050397709043112 Bray A, 2004, J LARYNGOL OTOL, V118, P123 COCHRAN WG, 1954, BIOMETRICS, V10, P417, DOI 10.2307/3001616 CUNNINGHAM D, 2006, HEAR J, V59, P58 Davis RR, 1998, AM IND HYG ASSOC J, V59, P715, DOI 10.1202/0002-8894(1998)059<0715:TIHPUI>2.0.CO;2 DEBIASE NG, 2003, CONHECIMENTOS ESSENC, P29 DRAKELEE AB, 1992, J ROY SOC MED, V85, P617 ELDIB RP, 2005, COCHRANE LIB El Dib RP, 2007, SAO PAULO MED J, V125, P362 FERNANDES M, 2002, REV BRAS OTORRINOLAR, V68 FERREIRA M, 1998, PERDA AUDITIVA INDUZ *HLTH SAF GUID, 2007, AM NOIS REQ REG IND HUMES LE, 1999, TRATADO AUDIOLOGIA C, P56 *IM SAUD, 2006, SECR AT SAUD DEP AC Jastreboff PJ, 2004, TINNITUS RETRAINING Kahari K, 2003, INT J AUDIOL, V42, P279, DOI 10.3109/14992020309078347 Kerr MJ, 2002, NURS RES, V51, P100, DOI 10.1097/00006199-200203000-00006 Laitinen H, 2005, Noise Health, V7, P21 LEINSTER P, 1994, ANN OCCUP HYG, V38, P644 Lusk SL, 2003, NURS RES, V52, P289, DOI 10.1097/00006199-200309000-00003 MAY JJ, 1990, AM J IND MED, V18, P333, DOI 10.1002/ajim.4700180315 MCBRIDE D, 1992, BRIT MED J, V305, P1561 Melamed S, 1996, HEALTH PSYCHOL, V15, P209, DOI 10.1037/0278-6133.15.3.209 MIRANDA CR, 1998, REV BRAS SAUDE OCUP, V25, P99 Nelson DI, 2005, AM J IND MED, V48, P446, DOI 10.1002/aijm.20223 OSTRI B, 1989, SCAND AUDIOL, V18, P243, DOI 10.3109/01050398909042202 Patel DS, 2001, J HEALTH COMMUN, V6, P155, DOI 10.1080/108107301750254484 Pocock SJ, 1983, CLIN TRIALS PRACTICA REDONDO MC, 1997, TRATADO FONOAUDIOLOG, P83 ROESER RJ, 2001, MANUAL CONSULTA RAPI, P1 ROYSTER JD, 1991, J ACOUST SOC AM, V89, P2793, DOI 10.1121/1.400719 Russo I. C. P., 1995, REV BRAS OTORRINOLAR, V61, P477 Samelli AG, 2000, ACTA AWHO, V19, P136 SANTOS UP, 1999, RUIDO RISCOS PREVENC, P43 SILVA RCM, 1998, TOPICOS FONOAUDIOLOG, V4, P81 Ventura D. P., 2003, CONHECIMENTOS ESSENC, P15 ZOBER A, 1984, ZBL BAKT MIK HYG B, V179, P1 NR 42 TC 3 Z9 4 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2458 J9 BMC PUBLIC HEALTH JI BMC Public Health PD MAY 7 PY 2008 VL 8 AR 151 DI 10.1186/1471-2458-8-151 PG 8 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 309TF UT WOS:000256482400001 PM 18462490 ER PT J AU Ramina, R Neto, MC Fernandes, YB Silva, EB Mattei, TA Aguiar, PHP AF Ramina, R. Neto, M. C. Fernandes, Y. B. Silva, E. B. Mattei, T. A. Aguiar, P. H. P. TI Surgical removal of small petroclival meningiomas SO ACTA NEUROCHIRURGICA LA English DT Article DE petroclival meningiomas; small petroclival meningiomas; surgery; radiosurgery; natural history; outcome ID SKULL BASE MENINGIOMAS; GAMMA-KNIFE SURGERY; NATURAL-HISTORY; ASYMPTOMATIC MENINGIOMAS; STEREOTACTIC RADIOSURGERY; INCIDENTAL MENINGIOMAS; POSTERIOR-FOSSA; GROWTH-RATE; GLIOBLASTOMA-MULTIFORME; EXPERIENCE AB Treatment of large petroclival meningiomas causing brain stem compression is surgical removal followed by radiotherapy or radiosurgery if the lesion was partially resected. The management of small petroclival meningiomas is, however, controversial. Clinical observation, radiosurgery and surgical removal are the options of treatment. The natural history of these tumours is not well known. Published series of patients treated with radiosurgery are not comparable with surgical series because the latter also includes large size tumours. In this paper we present a series of 18 patients with small petroclival meningiomas (diameter <= 2.8cm) treated with radical surgical removal. Total resection (Simpson's Grade 1) [43] was possible with minimal morbidity and no mortality. Background. We present a series of small petroclival meningiomas (SPM) treated by radical surgical removal and compare the outcome with other management modalities proposed for these lesions. Methods. Eighteen patients with SPM were surgically treated at our department of neurological surgery. The tumours were classified as small when they had a diameter < 3.0cm. Headaches (n = 12), diplopia (n = 8), facial hypoaesthesia (n = 3) and tinnitus (n = 6) were the most frequent symptoms at presentation. The approaches used were retrosigmoid (n = 14), fronto-orbito-zygomatic (n = 3) and presigmoid (n = 1). The post-operative follow-up ranged from 1 to 110 months (mean 41.8 months). Findings. Radical tumour resection (Simpson's Grades 1 and 2) was achieved in all patients. There was no major morbidity or mortality related to the surgical procedure. Transient abducent nerve palsy was the only post-operative complication. The pre-operative cranial nerves deficits improved after surgery. Only one patient had persistent diplopia postoperatively. Conclusion. Radical surgical removal of SPM is possible with minimal morbidity and may cure the patient. The effectiveness and outcome of surgery for small petroclival meningiomas should be compared with series treated by radiosurgery. C1 [Ramina, R.; Neto, M. C.; Silva, E. B.; Mattei, T. A.] Neurol Inst Curitiba, Dept Neurosurg, Curitiba, Parana, Brazil. [Ramina, R.; Silva, E. B.] Pontificial Catholic Univ Parana, Postgrad Course Surg, Curitiba, Parana, Brazil. [Fernandes, Y. B.] Univ Estadual Campinas, Dept Neurosurg, Campinas, SP, Brazil. [Aguiar, P. H. P.] Univ Sao Paulo, Dept Neurosurg, Sao Paulo, Brazil. RP Ramina, R (reprint author), R Goncalves Dias 713, BR-80240340 Curitiba, Parana, Brazil. 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PD MAY PY 2008 VL 150 IS 5 BP 431 EP 439 DI 10.1007/s00701-007-1403-y PG 9 WC Clinical Neurology; Surgery SC Neurosciences & Neurology; Surgery GA 299GS UT WOS:000255744700002 PM 18309454 ER PT J AU Balboni, AL Bergemann, AD Reidenberg, JS Laitman, JT AF Balboni, Armand L. Bergemann, Andrew D. Reidenberg, Joy S. Laitman, Jeffrey T. TI Tuberculosis induced changes to the osseous cranial base and its potential effect on hearing SO ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY LA English DT Article DE petro-occipital fissure; cochlear aqueduct; disseminated tuberculosis; hearing loss; tinnitus; vestibular dysfunction AB Our prior work suggested that petro-occipital fissure (POF) ossification may be altered in clinicopathologies of the cranial base such as hearing loss (Balboni et al., 2005). Here we demonstrate an accelerated and statistically significant ossification of the POF and cochlear aqueduct (CA) in a historical population of patients diagnosed with tuberculosis (TB). While a number of studies have sought to reduce the importance of the POF/CA to hearing, given its anatomical location, evolutionary conservation across mammals and the mounting data linking morphological changes of the POF/CA to the temporal onset of hearing loss and tinnitus, it is becoming difficult to maintain that its function is not related to inner ear homeostasis. C1 [Balboni, Armand L.; Reidenberg, Joy S.; Laitman, Jeffrey T.] Mt Sinai Sch Med, Ctr Anat & Funct Morphol, New York, NY 10029 USA. [Bergemann, Andrew D.] Mt Sinai Sch Med, Hans & Lillian Popper Dept Patho, New York, NY USA. [Laitman, Jeffrey T.] Mt Sinai Sch Med, Dept Otolaryngol, New York, NY USA. RP Balboni, AL (reprint author), Mt Sinai Sch Med, Ctr Anat & Funct Morphol, 1 Gustave L Levy Pl, New York, NY 10029 USA. EM armand.balboni@mssm.edu CR Balboni AL, 2005, ANAT REC PART A, V282A, P38, DOI 10.1002/ar.a.20149 Dye C, 2005, JAMA-J AM MED ASSOC, V293, P2767, DOI 10.1001/jama.293.22.2767 Kapp C, 2007, LANCET, V369, P729, DOI 10.1016/S0140-6736(07)60341-9 LUCENTE FE, 1978, LARYNGOSCOPE, V88, P1107 Thwaites GE, 2005, LANCET NEUROL, V4, P160, DOI 10.1016/S1474-4422(05)01013-6 NR 5 TC 1 Z9 1 PU WILEY-LISS PI HOBOKEN PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 1932-8486 J9 ANAT REC JI Anat. Rec. PD MAY PY 2008 VL 291 IS 5 BP 488 EP 490 DI 10.1002/ar.20675 PG 3 WC Anatomy & Morphology SC Anatomy & Morphology GA 293RB UT WOS:000255351300002 PM 18383278 ER PT J AU Pessin, AB Martins, RHG Pimenta, WD Simoes, ACP Marsiglia, A Amaral, AV AF Benito Pessin, Adriana Bueno Garcia Martins, Regina Helena Pimenta, Walkyiria de Paula Pereira Simoes, Antonio Caetano Marsiglia, Alessandra Amaral, Amanda Vieira TI Auditory evaluation in patients with type 1 diabetes SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article ID HEARING-LOSS; INNER-EAR; PERIPHERAL NEUROPATHY; MELLITUS; PATHWAY AB Objectives: We performed a prospective clinical study of the cochleovestibular symptoms and the risk cofactors and characteristics of hearing loss in patients with type 1 diabetes. Methods: Group I consisted of 40 patients with type I diabetes, and group 2 consisted of 20 control subjects without diabetes. All participants answered a questionnaire, and their medical records were reviewed. They also were submitted to otorhinolaryngological examinations and to auditory tests (pure tone audiometry and acoustic immitance and auditory brain stem response [ABR] tests). Results: Dyslipidemia, hypertension, retinopathy, and diabetic neuropathy were not frequent in the patients of group 1, but incipient nephropathy was present in 47.5% of them. The most frequent cochleovestibular symptoms were tinnitus and hearing loss. Sensorineural hearing loss was found in 4 patients of group I and was predominantly bilateral, symmetric, and affecting the high frequencies, coexisting with normal vocal discrimination. These patients had a longer time from diabetes diagnosis and had poor glycemia control. A delay of ABR interpeak latency I-III was observed in 11.25% of the group I ears. All patients of group 2 presented normal audiograms and ABR tests. Conclusions: In group 1, the most frequent cochleovestibular symptoms were tinnitus and hearing loss. The sensorineural hearing loss was mild, symmetric, and predominantly high-frequency. A delay of ABR interpeak latencies was detected in the patients of group I who had normal audiometric thresholds. C1 [Benito Pessin, Adriana Bueno; Garcia Martins, Regina Helena; Marsiglia, Alessandra; Amaral, Amanda Vieira] Sao Paulo State Univ, Sch Med, Fac Med Botucatu, Disciplina Otorrinolaringol,Dept Oftalmol Otorino, BR-18618970 Botucatu, SP, Brazil. [Pimenta, Walkyiria de Paula] Sao Paulo State Univ, Sch Med, Dept Internal Med, BR-18618970 Botucatu, SP, Brazil. [Pereira Simoes, Antonio Caetano] Sao Paulo State Univ, Sch Med, Dept Pediat, BR-18618970 Botucatu, SP, Brazil. RP Martins, RHG (reprint author), Sao Paulo State Univ, Sch Med, Fac Med Botucatu, Disciplina Otorrinolaringol,Dept Oftalmol Otorino, Distrito Rubiao Jr S-N, BR-18618970 Botucatu, SP, Brazil. 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Otol. Rhinol. Laryngol. PD MAY PY 2008 VL 117 IS 5 BP 366 EP 370 PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA 302KD UT WOS:000255966300008 PM 18564534 ER PT J AU Goldfine, AB Silver, R Aldhahi, W Cai, DS Tatro, E Lee, J Shoelson, SE AF Goldfine, Allison B. Silver, Robert Aldhahi, Waleed Cai, Dongsheng Tatro, Elizabeth Lee, Jongsoon Shoelson, Steven E. TI Use of Salsalate to Target Inflammation in the Treatment of Insulin Resistance and Type 2 Diabetes SO CTS-CLINICAL AND TRANSLATIONAL SCIENCE LA English DT Article DE salicylate; salsalate; inflammation; type 2 diabetes; insulin resistance; glucose; adiponectin ID NF-KAPPA-B; NITRIC-OXIDE SYNTHASE; SODIUM-SALICYLATE; ANTIINFLAMMATORY EFFICACY; RHEUMATOID-ARTHRITIS; ASPIRIN CONTRIBUTE; MONONUCLEAR-CELLS; ENDOTHELIAL-CELLS; ACETYL GROUP; IKK-BETA AB Objectives: Chronic subacute inflammation is implicated in the pathogenesis of insulin resistance and type 2 diabetes. Salicylates were shown years ago to lower glucose and more recently to inhibit NF-kappa B activity. Salsalate, a prodrug form of salicylate, has seen extensive clinical use and has a favorable safety profile. We studied the efficacy of salsalate in reducing glycemia and insulin resistance and potential mechanisms of action to validate NF-kappa B as a potential pharmacologic target in diabetes. Methods and Results: In open label studies, both high (4.5 g/d) and standard (3.0 g/d) doses of salsalate reduced fasting and postchallenge glucose levels after 2 weeks of treatment. Salsalate increased glucose utilization during euglycemic hyperinsulinemic clamps, by approximately 50% and 15% at the high and standard doses, respectively, and insulin clearance was decreased. Dose-limiting tinnitus occurred only at the higher dose. In a third, double-masked, placebo-controlled trial, 1 month of salsalate at maximum tolerable dose (no tinnitus) improved fasting and postchallenge glucose levels. Circulating free fatty acids were reduced and adiponectin increased in all treated subjects. Conclusions: These data demonstrate that salsalate improves in vivo glucose and lipid homeostasis, and support targeting of inflammation and NF-kappa B as a therapeutic approach in type 2 diabetes. C1 [Goldfine, Allison B.] Harvard Univ, Sch Med, Joslin Diabet Ctr, Boston, MA 02115 USA. Harvard Univ, Sch Med, Dept Med, Boston, MA USA. RP Goldfine, AB (reprint author), Harvard Univ, Sch Med, Joslin Diabet Ctr, Boston, MA 02115 USA. EM Allison.Goldfine@Joslin.Harvard.Edu FU NIH [R01 DK51729, R01 DK45943, K23 DK02795, P30 DK36836, M01 RR02635, M01 RR01032]; William Randolph Hearst Foundation [7-04-MN-47]; Helen and Morton Adler Chair FX We thank the staff of the Brigham and Women's Hospital General Clinical Research Center for their assistance, M. Freeman and J. Manning for analyses of fatty acid composition, Drs. Ernie Schaefer and Bela Asztalos for special assays, and G. I. Shulman and G. Cline for isotope analyses. These studies were supported by NIH grants R01 DK51729 and R01 DK45943 (SES), K23 DK02795 (ABG), P30 DK36836 and M01 RR02635 (Joslin Diabetes Center), and M01 RR01032 (Brigham and Women's Hospital), fellowships from the William Randolph Hearst Foundation (RJS) and American Diabetes Association 7-04-MN-47 (SES), and the Helen and Morton Adler Chair (SES). 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Transl. Sci. PD MAY PY 2008 VL 1 IS 1 BP 36 EP 43 DI 10.1111/j.1752-8062.2008.00026.x PG 8 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA 532RR UT WOS:000272767700011 PM 19337387 ER PT J AU Bakhshaee, M Ghasemi, M Azarpazhooh, M Khadivi, E Rezaei, S Shakeri, M Tale, M AF Bakhshaee, Mehdi Ghasemi, Mohammadmehdi Azarpazhooh, Mahmoodreza Khadivi, Ehsan Rezaei, Saman Shakeri, Mohammadtaghi Tale, Mohammadreza TI Gabapentin effectiveness on the sensation of subjective idiopathic tinnitus: a pilot study SO EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY LA English DT Article DE tinnitus; gabapentin; treatment ID MANAGEMENT AB This prospective, placebo-controlled, double-blind clinical trial evaluated the effectiveness of gabapentin in decreasing subjective features of idiopathic subjective tinnitus in the patients. Pure-tone audiograms, laboratory test and personal histories were used to exclude any particular etiology of tinnitus. Participants were restricted to those with moderate to severe idiopathic subjective tinnitus for at least 6 months. A total of 30 participants received gabapentin in a graduated ascending dose series extending over 4 weeks (peak dose of 900 mg/day). There was not a significant subjective improvement in tinnitus annoyance for the patients (37%) versus controls (42%). Comparison between the results before and after intervention for patients and controls according to subjective response, tinnitus questionnaire, tinnitus severity index and the loudness perception by the patient showed no significant differences (P > 0.05). There is insufficient evidence to support the effectiveness of gabapentin in the treatment of tinnitus up to now. C1 [Bakhshaee, Mehdi; Khadivi, Ehsan; Rezaei, Saman] Mashhad Univ Med Sci, Imam Reza Educ Hosp, Dept Otolaryngol Head & Neck Surg, Mashhad, Iran. [Ghasemi, Mohammadmehdi] Mashhad Univ Med Sci, Qaem Educ Hosp, Dept Otolaryngol Head & Neck Surg, Mashhad, Iran. [Azarpazhooh, Mahmoodreza] Mashhad Univ Med Sci, Qaem Educ Hosp, Dept Neurol, Mashhad, Iran. [Shakeri, Mohammadtaghi] Mashhad Univ Med Sci, Qaem Educ Hosp, Div Biostat, Dept Community Med, Mashhad, Iran. [Tale, Mohammadreza] Cohlear Implant Ctr, Mashhad, Iran. RP Bakhshaee, M (reprint author), Mashhad Univ Med Sci, Imam Reza Educ Hosp, Dept Otolaryngol Head & Neck Surg, Mashhad, Iran. 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Arch. Oto-Rhino-Laryn. PD MAY PY 2008 VL 265 IS 5 BP 525 EP 530 DI 10.1007/s00405-007-0504-9 PG 6 WC Otorhinolaryngology SC Otorhinolaryngology GA 284YD UT WOS:000254743400005 PM 17960408 ER PT J AU Praetorius, M Pfannenstiel, S Klingmann, C Baumann, I Plinkert, PK Staecker, H AF Praetorius, M. Pfannenstiel, S. Klingmann, C. Baumann, I. Plinkert, P. K. Staecker, H. TI Expression patterns of non-viral transfection with GFP in the organ of Corti in vitro and in vivo SO HNO LA English DT Article DE non-viral transfection; cochlea; gene therapy; inner ear ID MEDIATED GENE-TRANSFER; POLYAMIDOAMINE DENDRIMERS; TRANSGENE EXPRESSION; DRUG-DELIVERY; VECTOR; CELLS; EAR; POLYPLEXES; THERAPY; COCHLEA AB Background Diseases of the inner ear such as presbycusis, tinnitus, sudden hearing loss, and vertigo affect many patients, but so far there are no specific therapy options. Gene therapy might become a potential modality of treatment. Viral vectors are standard in animal models to date. Future considerations, however, call for a further evaluation of non-viral transfection methods. Materia and methods. The non-viral transfection agents Metafectene (TM), Superfect (TM), Effectene (TM), and Mirus TransIT (TM) were incubated with a plasmid coding for GFP. In vivo, the plasmid-agent mix was injected via the membrane of the round window, and 48 h later the inner ear was perfused, harvested, decalcified, and histologically evaluated for GFP expression. Results. Cationic lipids (Metafectene (TM)) and dendrimers (Superfect (TM)) were able to transfect cells in the area of the organ of Corti and lead to GFP expression. The polyamine (Mirus TransIT (TM)) did show expression of GFP in the area of Rosenthal's canal and in the area of the inner hair cell. The combination of a non-liposomal lipid with a DNA condensing component (Effectene (TM)) did not show transfection of the organ of Corti. In the area of the spiral ganglia cells, GFP expression was seen with all the transfection agents. Conclusions.Non-viral transfection agents are able to introduce a reporter gene in cells of the inner ear in vitro and in vivo. There are, however, differences in the efficiency of the transfection. They might be an alternative in gene therapy of the inner ear. Further investigations to elucidate their potential are needed. C1 [Praetorius, M.; Pfannenstiel, S.; Klingmann, C.; Baumann, I.; Plinkert, P. K.] Univ Klinikum Heidelberg, Sekt Otol Neuro Otol, Hals Nasen Ohrenklin Poliklin, D-69120 Heidelberg, Germany. [Pfannenstiel, S.; Staecker, H.] Univ Kansas, Dept Otolaryngol, Kansas City, KS USA. RP Praetorius, M (reprint author), Univ Klinikum Heidelberg, Sekt Otol Neuro Otol, Hals Nasen Ohrenklin Poliklin, Im Neuenheimer Feld 400, D-69120 Heidelberg, Germany. EM mark.praetorius@med.uni-heidelberg.de CR AKHTAR S, 2005, GENE THER, V13, P739 Bates MK, 2006, BIOTECHNIQUES, V40, P199, DOI 10.2144/000112088 Behr JP, 1997, CHIMIA, V51, P34 De Jesus OLP, 2002, BIOCONJUGATE CHEM, V13, P453, DOI 10.1021/bc010103m DWORETZKY SI, 1988, J CELL BIOL, V107, P1279, DOI 10.1083/jcb.107.4.1279 Gebhart CL, 2001, J CONTROL RELEASE, V73, P401, DOI 10.1016/S0168-3659(01)00357-1 Han JJ, 1999, HUM GENE THER, V10, P1867, DOI 10.1089/10430349950017545 Hudde T, 1999, GENE THER, V6, P939, DOI 10.1038/sj.gt.3300886 KukowskaLatallo JF, 1996, P NATL ACAD SCI USA, V93, P4897, DOI 10.1073/pnas.93.10.4897 Lalwani AK, 1998, GENE THER, V5, P277, DOI 10.1038/sj.gt.3300573 MELCHIOR F, 1995, CURR OPIN CELL BIOL, V7, P310, DOI 10.1016/0955-0674(95)80084-0 MICHEL O, 1991, Laryngo- Rhino- Otologie, V70, P255 Parker Alan L., 2003, Expert Reviews in Molecular Medicine, V5, P1 Praetorius M, 2003, ORL J OTO-RHINO-LARY, V65, P211, DOI 10.1159/000073117 Raphael Y, 1996, NEUROSCI LETT, V207, P137, DOI 10.1016/0304-3940(96)12499-X Salt AN, 2005, DRUG DISCOV TODAY, V10, P1299, DOI 10.1016/S1359-6446(05)03574-9 Sonawane ND, 2003, J BIOL CHEM, V278, P44826, DOI 10.1074/jbc.M308643200 Staecker H, 2001, ACTA OTO-LARYNGOL, V121, P157 Staecker H, 1998, OTOLARYNG HEAD NECK, V119, P7, DOI 10.1016/S0194-5998(98)70194-9 Stover T, 2000, GENE THER, V7, P377, DOI 10.1038/sj.gt.3301108 Uchida E, 2002, BIOL PHARM BULL, V25, P891, DOI 10.1248/bpb.25.891 Vio MM, 2005, DRUG DISCOV TODAY, V10, P1263, DOI 10.1016/S1359-6446(05)03594-4 Zuhorn IS, 2002, J BIOL CHEM, V277, P18021, DOI 10.1074/jbc.M111257200 NR 23 TC 7 Z9 7 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0017-6192 J9 HNO JI HNO PD MAY PY 2008 VL 56 IS 5 BP 524 EP 529 DI 10.1007/s00106-008-1738-6 PG 6 WC Otorhinolaryngology SC Otorhinolaryngology GA 298IJ UT WOS:000255681100007 PM 18409074 ER PT J AU Thapa, R Mukherjee, S AF Thapa, Rajoo Mukherjee, Swapan TI Transient bilateral oculomotor palsy in pseudotumor cerebri SO JOURNAL OF CHILD NEUROLOGY LA English DT Article DE pseudotumor cerebri; oculomotor nerve; intracranial pressure ID IDIOPATHIC INTRACRANIAL HYPERTENSION AB Pseudotumor cerebri is a clinical condition marked by papilledema, normal cerebrospinal fluid composition, normal or small ventricles on radiography, and absence of an intracranial mass. In this condition, headache, tinnitus, dizziness, blurred vision, and diplopia are frequently observed. The cause is often unknown but can occur with certain drug ingestions or systemic inflammatory and metabolic diseases. The treatment is primarily focused on the correction of the underlying cause with measures to reduce the raised intracranial pressure. The most important complication is optic atrophy, which results in visual loss. The sixth cranial nerve is most commonly affected. The involvement of the third cranial nerve is distinctly unusual. The present report describes a unique case of bilateral oculomotor palsy with sparing of the papillary fibers. It resolved promptly on administration of acetazolamide. C1 Inst Child Hlth, Dept Pediat, Kolkata 700017, W Bengal, India. Inst Child Hlth, Pediat Neurol Unit, Kolkata 700017, W Bengal, India. RP Thapa, R (reprint author), Inst Child Hlth, Dept Pediat, 11 Dr Biresh Guha St, Kolkata 700017, W Bengal, India. EM rajoothapa@yahoo.co.in CR Agarwal M P, 1989, J Assoc Physicians India, V37, P533 Bakshi S K, 1992, J Postgrad Med, V38, P144 Capobianco DJ, 1997, HEADACHE, V37, P286, DOI 10.1046/j.1526-4610.1997.3705286.x DURCAN FJ, 1988, ARCH NEUROL-CHICAGO, V45, P875 Friedman DI, 2002, NEUROLOGY, V59, P1492 Kotagal S, 2006, PEDIAT NEUROLOGY PRI, P1522 MCCAMMON A, 1981, NEUROLOGY, V31, P182 Phillips P H, 1998, J AAPOS, V2, P33, DOI 10.1016/S1091-8531(98)90107-0 SMITH JL, 1985, J CLIN NEURO-OPHTHAL, V5, P55 SNYDER DA, 1979, ANN OPHTHALMOL, V11, P1823 NR 10 TC 9 Z9 9 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0883-0738 EI 1708-8283 J9 J CHILD NEUROL JI J. Child Neurol. PD MAY PY 2008 VL 23 IS 5 BP 580 EP 581 DI 10.1177/0883073807309774 PG 2 WC Clinical Neurology; Pediatrics SC Neurosciences & Neurology; Pediatrics GA 292XO UT WOS:000255299600017 PM 18448574 ER PT J AU Gungor, A Dogru, S Cincik, H Erkul, E Poyrazoglu, E AF Gungor, A. Dogru, S. Cincik, H. Erkul, E. Poyrazoglu, E. TI Effectiveness of transmeatal low power laser irradiation for chronic tinnitus SO JOURNAL OF LARYNGOLOGY AND OTOLOGY LA English DT Article DE tinnitus; lasers ID THERAPY AB Objective: To evaluate effectiveness of 5 mW laser irradiation in the treatment of chronic tinnitus. Study design: Prospective, randomised, double-blind study. Methods: This investigation included 66 ears in 45 patients with chronic unilateral or bilateral tinnitus. A 5 mW laser with a wavelength of 650 nm, or placebo laser, was applied transmeatally for 15 minutes, once daily for a week. A questionnaire was administered which asked patients to score their symptoms on a five-point scale, before and two weeks after laser irradiation. A decrease of one scale point, regarding the loudness, duration and degree of annoyance of tinnitus, was accepted to represent an improvement. Results: The loudness, duration and degree of annoyance of tinnitus were improved, respectively, in up to 48.8, 57.7 and 55.5 per cent of the patients in the active laser group. No significant improvement was observed in the placebo laser group. Conclusion: Transmeatal, low power (5 mW) laser irradiation was found to be useful for the treatment of chronic tinnitus. C1 [Gungor, A.; Dogru, S.; Cincik, H.; Erkul, E.; Poyrazoglu, E.] Haydarpasa Training Hosp, Dept Otolaryngol, Istanbul, Turkey. RP Dogru, S (reprint author), Haydarpasa Training Hosp, Dept Otolaryngol Head & Neck Surg, TR-34668 Kadikoy, Turkey. EM salimdogru@yahoo.com CR ABERGEL RP, 1987, J DERMATOL SURG ONC, V13, P127 BASFORD JR, 1995, LASER SURG MED, V16, P331, DOI 10.1002/lsm.1900160404 CHOMETTE G, 1987, J BIOL BUCCALE, V15, P45 Hahn A, 2001, ACTA OTO-LARYNGOL, P92 Hans HFI, 1992, LASER SURG MED, V12, P528, DOI 10.1002/lsm.1900120512 HARRIS DM, 1988, LASER TOPICS, V1, P9 Lam T. S., 1986, Lasers in the Life Sciences, V1 MESTER E, 1985, LASER SURG MED, V5, P31, DOI 10.1002/lsm.1900050105 Mirz F, 1999, CLIN OTOLARYNGOL, V24, P346, DOI 10.1046/j.1365-2273.1999.00277.x Nakashima T, 2002, OTOL NEUROTOL, V23, P296, DOI 10.1097/00129492-200205000-00011 PASSARELLA S, 1984, FEBS LETT, V175, P95, DOI 10.1016/0014-5793(84)80577-3 Schaffer M, 2000, J PHOTOCH PHOTOBIO B, V54, P55, DOI 10.1016/S1011-1344(99)00155-4 Shiomi Y., 1997, Auris Nasus Larynx, V24, P39, DOI 10.1016/S0385-8146(96)00003-X Simunovic Z, 1996, J Clin Laser Med Surg, V14, P163 Tauber S, 2001, LASER SURG MED, V28, P18, DOI 10.1002/1096-9101(2001)28:1<18::AID-LSM1011>3.0.CO;2-C Walker JB, 1987, CLIN J PAIN, V3, P54, DOI 10.1097/00002508-198703010-00009 Wilden L., 1996, Laser Therapy, V8, P209 Yu W., 1994, LASERS SURG MED S, V6, P8 Zhu QY, 1997, LASER SURG MED, V20, P332, DOI 10.1002/(SICI)1096-9101(1997)20:3<332::AID-LSM12>3.0.CO;2-F NR 19 TC 8 Z9 8 PU CAMBRIDGE UNIV PRESS PI CAMBRIDGE PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND SN 0022-2151 J9 J LARYNGOL OTOL JI J. Laryngol. Otol. PD MAY PY 2008 VL 122 IS 5 BP 447 EP 451 DI 10.1017/S0022215107009619 PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA 299QV UT WOS:000255771000003 PM 17625032 ER PT J AU Marti, S Hegemann, S von Budingen, HC Baumgartner, RW Straumann, D AF Marti, Sarah Hegemann, Stefan von Buedingen, Hans-Christian Baumgartner, Ralf W. Straumann, Dominik TI Rotational vertebral artery syndrome - 3D kinematics of nystagmus suggest bilateral labyrinthine dysfunction SO JOURNAL OF NEUROLOGY LA English DT Article DE vertebral artery; compression; vertigo; labyrinthine ischemia; downbeat nystagmus ID EYE-MOVEMENTS; OCCLUSION; ISCHEMIA AB Whether the rotational vertebral artery syndrome (RVAS), consisting of attacks of vertigo, nystagmus and tinnitus elicited by head-rotation induced compression of the dominant vertebral artery (VA), reflects ischemic dysfunction of uni- or bilateral peripheral or central vestibular structures, is still debated. We report on a patient with bilateral high-grade carotid stenoses, in whom rightward head-rotation led to RVAS symptoms including a prominent nystagmus. Three-dimensional kinematic analysis of the nystagmus pattern, recorded with search coils, revealed major downbeat nystagmus with minor horizontal and torsional components. Magnetic resonance angiography demonstrated a hypoplastic right VA terminating in the posterior inferior cerebellar artery, a dominant left VA, and a hypoplastic P1-segment of the left posterior cerebral artery (PCA) that was supplied by the left posterior communicating artery (PCoA). The right PCA and both anterior inferior cerebellar arteries were supplied by the basilar artery. The right PCoA originated from the right internal carotid artery. Color duplex sonography showed severe reduction of diastolic blood flow velocities in the left VA during RVAS attacks. The nystagmus pattern can be best explained by vectorial addition of 3D sensitivity vectors of stimulated right and left anterior and horizontal semicircular canals with slightly stronger stimulation on the left side. We hypothesize that in RVAS, compression of dominant VA leads to acute vertebrobasilar insufficiency with bilateral, but asymmetric ischemia of the superior labyrinth. With regard to RVAS etiology, our case illustrates a type of pure vascular RVAS. Severity of attacks markedly decreased after successful bilateral carotid endarterectomy. C1 [Marti, Sarah; von Buedingen, Hans-Christian; Baumgartner, Ralf W.; Straumann, Dominik] Univ Zurich Hosp, Dept Neurol, CH-8091 Zurich, Switzerland. [Hegemann, Stefan] Univ Zurich Hosp, Dept Otorhinolaryngol, CH-8091 Zurich, Switzerland. RP Marti, S (reprint author), Univ Zurich Hosp, Dept Neurol, Frauenklin Str 26, CH-8091 Zurich, Switzerland. EM sarah.marti@usz.ch RI Hegemann, Stefan/B-4640-2013 OI Hegemann, Stefan/0000-0002-9464-352X CR BALOH RW, 1996, DISORDERS VESTIBULAR, P418 Brandt T, 2005, NEUROLOGY, V65, P1156, DOI 10.1212/01.wnl.0000183154.93624.ac Choi KD, 2005, NEUROLOGY, V65, P1287, DOI 10.1212/01.wnl.0000180405.00560.51 COHEN B, 1964, ANN OTO RHINOL LARYN, V73, P153 Kim JS, 1999, NEUROLOGY, V52, P40 Kuether TA, 1997, NEUROSURGERY, V41, P427, DOI 10.1097/00006123-199708000-00019 Leigh RJ, 2006, NEUROLOGY EYE MOVEME Mazzoni A, 1990, Acta Otolaryngol Suppl, V472, P1 SITKO S, 1986, ACTA OTO-LARYNGOL, V102, P179, DOI 10.3109/00016488609108664 Strupp M, 2000, NEUROLOGY, V54, P1376 STURZENEGGER M, 1994, STROKE, V25, P1776 TATLOW W, 2006, NEUROLOGY, V7, P331 ZEE DS, 1981, J NEUROPHYSIOL, V46, P878 NR 13 TC 10 Z9 10 PU DR DIETRICH STEINKOPFF VERLAG PI DARMSTADT PA PO BOX 10 04 62, D-64204 DARMSTADT, GERMANY SN 0340-5354 J9 J NEUROL JI J. Neurol. PD MAY PY 2008 VL 255 IS 5 BP 663 EP 667 DI 10.1007/s00415-008-0773-2 PG 5 WC Clinical Neurology SC Neurosciences & Neurology GA 311EH UT WOS:000256583000008 PM 18274804 ER PT J AU Harrison, RV AF Harrison, Robert V. TI Noise-induced hearing loss in children: A 'less than silent' environmental danger SO PAEDIATRICS & CHILD HEALTH LA English DT Article DE acoustic trauma; hair cell damage; noise-induced hearing loss; recreational music ID PERSONAL LISTENING DEVICES; STRONGLY AMPLIFIED MUSIC; YOUNG-ADULTS; DAMAGE; REGENERATION; PLASTICITY; TINNITUS; RISKS; MODEL AB A review of the problems of noise-induced hearing loss in children, especially related to recreational music and the use of personal entertainment devices. The pathophysiology of noise-induced hearing loss and its associated problems (eg, tinnitus) are discussed. The evidence for an increase in noise-induced hearing loss in children and Young people is reviewed. Some practical advice (for clinicians, caregivers and children) on hearing loss prevention is provided. C1 [Harrison, Robert V.] Hosp Sick Children, Div Neurosci & Mental Hlth, Toronto, ON M5G 1X8, Canada. [Harrison, Robert V.] Univ Toronto, Dept Otolaryngol Head & Neck Surg, Toronto, ON, Canada. [Harrison, Robert V.] Univ Toronto, Dept Physiol, Toronto, ON, Canada. RP Harrison, RV (reprint author), Hosp Sick Children, Div Neurosci & Mental Hlth, 555 Univ Ave, Toronto, ON M5G 1X8, Canada. 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Child Health PD MAY-JUN PY 2008 VL 13 IS 5 BP 377 EP 382 PG 6 WC Pediatrics SC Pediatrics GA 314AS UT WOS:000256781700005 PM 19412364 ER PT J AU Davis, CG Morgan, MS AF Davis, Christopher G. Morgan, Melinda S. TI Finding meaning, perceiving growth, and acceptance of tinnitus SO REHABILITATION PSYCHOLOGY LA English DT Article DE meaning; growth; acceptance; tinnitus ID POSTTRAUMATIC GROWTH; THREATENING EVENTS; ASSUMPTIVE WORLDS; COLLEGE-STUDENTS; SENSE-MAKING; SINGLE-ITEM; ADJUSTMENT; BEREAVEMENT; SEARCH; CANCER AB Objectives: The authors test hypotheses derived from current models of growth following adversity in a sample of people with tinnitus. These models assume a process whereby adversity or trauma threatens major assumptions, which, in turn, promotes a search for meaning in the adversity and subsequently growth. Method. Data from a sample of 315 people with tinnitus who completed an online survey were used to assess the relations of reports of negative changes to asking "Why me?" and answering the Why me? question with reports of growth, acceptance, and well-being. Results: indicate that reports of negative changes in goals and philosophy of life predict a search for meaning and that finding meaning is associated with perceived growth. Those who report never searching for meaning are less likely to report growth but report better adjustment and acceptance of their tinnitus than those who have searched for meaning. Discussion: The data are consistent with models of growth that give a central role to meaning-making processes, but they also suggest that a significant minority of people with tinnitus do not report searching for meaning or perceiving growth-yet appear to be coping well. Acceptance of tinnitus is identified as a key construct for future research. 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A., 1983, PHYS DISABILITY PSYC Zoellner T, 2006, CLIN PSYCHOL REV, V26, P626, DOI 10.1016/j.cpr.2006.01.008 NR 72 TC 22 Z9 23 PU EDUCATIONAL PUBLISHING FOUNDATION PI WASHINGTON PA 750 FIRST ST, NE, WASHINGTON, DC 20002-4242 USA SN 0090-5550 J9 REHABIL PSYCHOL JI Rehabil. Psychol. PD MAY PY 2008 VL 53 IS 2 BP 128 EP 138 DI 10.1037/0090-5550.53.2.128 PG 11 WC Psychology, Clinical; Rehabilitation SC Psychology; Rehabilitation GA 313AF UT WOS:000256712800003 ER PT J AU Lekovic, GP Gonzalez, LF Weisskopf, P Smith, KA AF Lekovic, Gregory P. Gonzalez, L. Fernando Weisskopf, Peter Smith, Kris A. TI Hearing improvement after resection of a large jugular foramen schwannoma: Case report SO SKULL BASE-AN INTERDISCIPLINARY APPROACH LA English DT Article DE jugular foramen schwannoma; hearing; retrosigmoid craniotomy; cerebellopontine angle ID WORD DEAFNESS; TUMOR; PRESERVATION; REMOVAL AB Although hearing improvement after surgery for small tumors of the cerebellopontine angle has been reported, the mechanism by which surgery leads to the improvement in hearing remains controversial. We report a patient who sought treatment for progressive tinnitus and hearing loss. Magnetic resonance imaging showed a large (5-cm) schwannoma in the cerebellopontine angle. At surgery the lesion was found to originate from rootlets of cranial nerve X at the jugular foramen. The patient underwent gross total resection of the tumor. Immediately after surgery, his hearing improved dramatically. We believe that our patient represents an example of hearing impairment at least in part referable to direct compression of the brainstem. Importantly, the patient's hearing deficit was completely reversible. Some authors claim that surgery to preserve hearing may be contraindicated in patients with speech discrimination scores below 50%. However, when extrinsic brainstem compression may contribute to the cause of such a hearing decrement, postoperative improvement in hearing may be a reasonable expectation. C1 [Weisskopf, Peter] St Joseph Hosp & Med Ctr, Barrow Neurol Inst, Dept Neuro Otol, Phoenix, AZ 85013 USA. [Lekovic, Gregory P.; Gonzalez, L. Fernando; Smith, Kris A.] St Joseph Hosp & Med Ctr, Barrow Neurol Inst, Div Neurol Surg, Phoenix, AZ 85013 USA. RP Smith, KA (reprint author), Care of Neurosci Publ, Barrow Neurol Inst, 350 W Thomas Rd, Phoenix, AZ 85013 USA. 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PD MAY PY 2008 VL 18 IS 3 BP 195 EP 199 DI 10.1055/s-2007-1016960 PG 5 WC Clinical Neurology; Otorhinolaryngology; Surgery SC Neurosciences & Neurology; Otorhinolaryngology; Surgery GA 297VR UT WOS:000255646000006 PM 18978966 ER PT J AU Landgrebe, M Binder, H Koller, M Eberl, Y Kleinjung, T Eichhammer, P Graf, E Hajak, G Langguth, B AF Landgrebe, Michael Binder, Harald Koller, Michael Eberl, Yvonne Kleinjung, Tobias Eichhammer, Peter Graf, Erika Hajak, Goeran Langguth, Berthold TI Design of a placebo-controlled, randomized study of the efficacy of repetitive transcranial magnetic stimulation for the treatment of chronic tinntius SO BMC PSYCHIATRY LA English DT Article ID POSITRON-EMISSION-TOMOGRAPHY; CHRONIC TINNITUS; AUDITORY HALLUCINATIONS; BRAIN; DEPRESSION; CORTEX; EXCITABILITY; SUPPRESSION; ACTIVATION; INVENTORY AB Background: Chronic tinnitus is a frequent condition, which can have enormous impact on patient's life and which is very difficult to treat. Accumulating data indicate that chronic tinnitus is related to dysfunctional neuronal activity in the central nervous system. Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive method which allows to focally modulate neuronal activity. An increasing amount of studies demonstrate reduction of tinnitus after repeated sessions of low-frequency rTMS and indicate that rTMS might represent a new promising approach for the treatment of tinnitus. However available studies have been mono-centric and are characterized by small sample sizes. Therefore, this multi-center trial will test the efficacy of rTMS treatment in a large sample of chronic tinnitus patients. Methods/Design: This is a randomized, placebo-controlled, double-blind multi-center trial of two weeks 1 Hz rTMS-treatment in chronic tinnitus patients. Eligible patients will be randomized to either 2 weeks real or sham rTMS treatment. Main eligibility criteria: male or female individuals aged 18-70 years with chronic tinnitus (duration > 6 months), tinnitus-handicap-inventory-score >= 38, age-adjusted normal sensorineural hearing (i.e. not more than 5 dB below the 10% percentile of the appropriate age and gender group (DIN EN ISO 7029), conductive hearing loss <= 15dB. The primary endpoint is a change of tinnitus severity according to the tinnitus questionnaire of Goebel and Hiller (baseline vs. end of treatment period). A total of 138 patients are needed to detect a clinical relevant change of tinnitus severity (i.e. 5 points on the questionnaire of Goebel and Hiller; alpha = 0.05; 1-beta = 0.80). Assuming a drop-out rate of less than 5% until the primary endpoint, 150 patients have to be randomized to guarantee the target number of 138 evaluable patients. The study will be conducted by otorhinolaryngologists and psychiatrists of 7 university hospitals and 1 municipal hospital in Germany. Discussion: This study will provide important information about the efficacy of rTMS in the treatment of chronic tinnitus. Trial registration: Current Controlled Trials ISRCTN89848288. C1 [Landgrebe, Michael; Eichhammer, Peter; Hajak, Goeran; Langguth, Berthold] Univ Regensburg, Dept Psychiat Psychosomat & Psychotherapy, D-8400 Regensburg, Germany. [Koller, Michael; Eberl, Yvonne] Univ Hosp Regensburg, Ctr Clin Studies, Regensburg, Germany. [Kleinjung, Tobias] Univ Hosp Regensburg, Dept Otorhinolaryngol, Regensburg, Germany. [Binder, Harald; Graf, Erika] Univ Med Ctr Freiburg, Inst Med Biometry & Med Informat, Freiburg, Germany. RP Landgrebe, M (reprint author), Univ Regensburg, Dept Psychiat Psychosomat & Psychotherapy, D-8400 Regensburg, Germany. EM michael.landgrebe@medbo.de; binderh@fdm.uni-freiburg.de; michael.koller@klinik.uni-regensburg.de; Yvonne1.Eberl@klinik.uni-regensburg.de; tobias.kleinjung@klinik.uni-regensburg.de; peter.eichhammer@medbo.de; erika.graf@uniklinik-freiburg.de; goeran.hajak@medbo.de; berthold.langguth@medbo.de RI Binder, Harald/C-7413-2009 OI Binder, Harald/0000-0002-5666-8662 CR Arnold W, 1996, ORL J OTO-RHINO-LARY, V58, P195 BECK AT, 1984, J CLIN PSYCHOL, V40, P1365, DOI 10.1002/1097-4679(198411)40:6<1365::AID-JCLP2270400615>3.0.CO;2-D BULLINGER M, 1998, SF 12 Chen R, 1997, NEUROLOGY, V48, P1398 COSTA PT, 1993, NEO FUNFFAKTOREN INV De Ridder D, 2005, OTOL NEUROTOL, V26, P616, DOI 10.1097/01.mao.0000178146.91139.3c Dobie RA, 1999, LARYNGOSCOPE, V109, P1202, DOI 10.1097/00005537-199908000-00004 Eichhammer P, 2003, BIOL PSYCHIAT, V54, P862, DOI 10.1016/S0006-3223(03)01896-6 Friedman LM, 1998, FUNDAMENTALS CLIN TR, P82 Gershon AA, 2003, AM J PSYCHIAT, V160, P835, DOI 10.1176/appi.ajp.160.5.835 Grisaru N, 1998, BIOL PSYCHIAT, V44, P52, DOI 10.1016/S0006-3223(98)00016-X HILLER W, 1992, J PSYCHOSOM RES, V36, P337, DOI 10.1016/0022-3999(92)90070-I Hoffman RE, 2002, AM J PSYCHIAT, V159, P1093, DOI 10.1176/appi.ajp.159.7.1093 Hoffman RE, 2005, BIOL PSYCHIAT, V58, P97, DOI 10.1016/j.biopsych.2005.03.041 Hoffman RE, 2000, LANCET, V355, P1073, DOI 10.1016/S0140-6736(00)02043-2 Jennison C, 2000, GROUP SEQUENTIAL MET Kleinjung T, 2007, OTOLARYNG HEAD NECK, V137, P589, DOI 10.1016/j.otohns.2006.12.007 Kleinjung T, 2005, OTOLARYNG HEAD NECK, V132, P566, DOI 10.1016/j.otohns.2004.09.134 Langguth B, 2006, BRAIN TOPOGR, V18, P241, DOI 10.1007/s10548-006-0002-1 Langguth B, 2007, BMC NEUROSCI, V8, DOI 10.1186/1471-2202-8-45 Langguth B, 2007, PROG BRAIN RES, V166, P525, DOI 10.1016/S0079-6123(07)66050-6 Lisanby SH, 2001, BIOL PSYCHIAT, V49, P460, DOI 10.1016/S0006-3223(00)01110-0 Lockwood A H, 1999, Scand Audiol Suppl, V51, P47 May A, 2007, CEREB CORTEX, V17, P205, DOI 10.1093/cercor/bhj138 Melcher JR, 2000, J NEUROPHYSIOL, V83, P1058 Mirz F, 1999, HEARING RES, V134, P133, DOI 10.1016/S0378-5955(99)00075-1 Moller AR, 2003, OTOLARYNG CLIN N AM, V36, P249, DOI 10.1016/S003-6665(02)00170-6 Muhlau M, 2006, CEREB CORTEX, V16, P1283, DOI 10.1093/cercor/bhj070 Newman CW, 1996, ARCH OTOLARYNGOL, V122, P143 Plewnia C, 2003, ANN NEUROL, V53, P263, DOI 10.1002/ana.10468 Plewnia C, 2007, J NEUROL NEUROSUR PS, V78, P152, DOI 10.1136/jnnp.2006.095612 Reyes SA, 2002, HEARING RES, V171, P43, DOI 10.1016/S0378-5955(02)00346-5 ROSSI S, 2007, J NEUROL NEUROSURG P ROSSINI PM, 1994, ELECTROEN CLIN NEURO, V91, P79, DOI 10.1016/0013-4694(94)90029-9 Schumacher J, 2005, Z KLIN PSYCH PSYCHIA, V53, P16 Siebner HR, 2003, BRAIN, V126, P2710, DOI 10.1093/brain/awg282 Smith JA, 2007, LARYNGOSCOPE, V117, P529, DOI 10.1097/MLG.0b013e31802f4154 Tergau F, 1999, LANCET, V353, P2209, DOI 10.1016/S0140-6736(99)01301-X Wassermann EM, 1998, EVOKED POTENTIAL, V108, P1, DOI 10.1016/S0168-5597(97)00096-8 NR 39 TC 20 Z9 20 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-244X J9 BMC PSYCHIATRY JI BMC Psychiatry PD APR 15 PY 2008 VL 8 AR 23 DI 10.1186/1471-244X-8-23 PG 9 WC Psychiatry SC Psychiatry GA 296RD UT WOS:000255562600001 PM 18412944 ER PT J AU Chatrath, P Frosh, A Gore, A Nouraei, R Harcourt, J AF Chatrath, P. Frosh, A. Gore, A. Nouraei, R. Harcourt, J. TI Identification of predictors and development of a screening protocol for cerebello-pontine lesions in patients presenting with audio-vestibular dysfunction SO CLINICAL OTOLARYNGOLOGY LA English DT Article ID ACOUSTIC NEUROMA; VESTIBULAR SCHWANNOMA; DIAGNOSIS; HEARING; SYMPTOMS; EARS; MRI AB Objectives: Magnetic resonance imaging (MRI) scanning in the investigation of cerebellopontine angle lesions represents a finite resource, the use of which needs to be carefully rationalised. Our aim was to identify predictive factors that can distinguish between patients with and without cerebellopontine angle lesions, and develop a screening protocol which could be useful in the clinical setting as an aid to clinical judgment. Design: Case-control study. Setting: Secondary care. Participants: Audio-vestibular features were collated on 136 patients (M : F 1.39 : 1) and 288 controls (M : F 1 : 1.1). Intervention: Diagnostic by analysis of symptoms and audiometric data using logistic regression, receiver-operator characteristic curves and backwards elimination. Main outcome measures: Development of a predictive algorithm comprising those factors which are most strongly predictive of the presence of a cerebellopontine angle lesion. Results: Positive predictors of a cerebellopontine angle lesion include the interaural threshold difference at 1 (P = 0.044) and 4 kHz (P = 0.034). The threshold in the better hearing ear at 0.25 kHz exerts a negative predictive (i.e. protective) effect (P = 0.005). The presence of tinnitus does not appear to influence the outcome on logistic regression. Although vertigo does exert an influence on the overall model, its impact is highly equivocal. Conclusions: We have identified audiometric factors which exert a positive and negative predictive influence on the presence of a cerebellopontine angle lesion, and audiovestibular symptoms which appear to exert little effect on the model. Our predictive equation represents a user-friendly standardised method of risk-stratification of patients within a general otolaryngology clinic. C1 [Chatrath, P.; Frosh, A.; Nouraei, R.; Harcourt, J.] Charing Cross Hosp, Dept Otolaryngol, London, England. [Gore, A.] Inst Publ Hlth, GPPCRU, CAMS, Cambridge, England. RP Chatrath, P (reprint author), Charing Cross Hosp, Dept Otolaryngol, London, England. 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Otolaryngol. PD APR PY 2008 VL 33 IS 2 BP 102 EP 107 DI 10.1111/j.1749-4486.2008.01667.x PG 6 WC Otorhinolaryngology SC Otorhinolaryngology GA 290QD UT WOS:000255136400004 PM 18429858 ER PT J AU Anagnostopoulou, S Venieratos, D Antonopoulou, M AF Anagnostopoulou, Sophia Venieratos, Dionyssios Antonopoulou, Maria TI Temporomandibular joint and correlated fissures: Anatomical and clinical consideration SO CRANIO-THE JOURNAL OF CRANIOMANDIBULAR PRACTICE LA English DT Article ID PETROTYMPANIC FISSURE; MANDIBULAR CONDYLE; MIDDLE-EAR; TINNITUS; LIGAMENT; RECONSTRUCTION; PROSTHESIS; DISORDERS; VERTIGO; DAMAGE AB An anatomical study of the fissures related to the temporomandibular joint (TMJ) was performed in 40 dry human skulls. The length of the squamotympanic fissure (X), as well as those of the petrotympanic fissure (Y) and the (descending part of) the petrosquamous fissure (Z), into which the first of them (as a rule) branches, was measured. The distances between the point of this bifurcation and the deepest point of the glenoid fossa (A), the articular tubercle (B), and the styloid process (C) of the TMJ were also measured. The distances measured presented a significant variability among different specimens. In particular, the lengths (X, Y, and Z) of some fissures measured twice as great compared to other ones. All distance measurements were expressed in mm. Dysfunction of the TMJ may lead to a variety of ear symptoms, i.e., otalgia, tinnitus, hearing loss, possibly vertigo and, less often, to tongue symptoms (collectively characterized as temporomandibular syndrome). These symptoms often relate to the important anatomic structures (anterior malleolar ligament, anterior tympanic artery and chorda tympani nerve) coursing (mainly) through the petrotympanic fissure, whose length and position may exert considerable impact. The measured distances (hardly assessable through a plain radiogram) may also be considered as parameters that need to be taken into account in view of an eventual replacement of a poorly functioning TMJ by a suitable prosthesis. C1 [Anagnostopoulou, Sophia; Venieratos, Dionyssios; Antonopoulou, Maria] Univ Athens, Dept Anat, Sch Med, GR-11527 Athens, Greece. RP Venieratos, D (reprint author), Univ Athens, Dept Anat, Sch Med, 75 Mikras Asias Str, GR-11527 Athens, Greece. EM dvenieratos@med.uoa.gr CR ANAGNOSTOPOULOU S, 1986, ACTA ANAT, V127, P201 ANDERSEN HT, 1971, ACTA PHYSIOL SCAND, V83, P150, DOI 10.1111/j.1748-1716.1971.tb05063.x Bartoshuk LM, 2005, CHEM SENSES, V30, pI218, DOI 10.1093/chemse/bjh192 Berkovitz BK, 2005, GRAYS ANATOMY ANATOM, P526 Bernstein J M, 1969, Trans Am Acad Ophthalmol Otolaryngol, V73, P1208 BJORNE A, 2003, J CRANIOMANDIB PRACT, V21, P50 Bland M, 2000, INTRO MED STAT BURCH JG, 1966, ANAT REC, V156, P433, DOI 10.1002/ar.1091560407 CHASE DC, 1995, ORAL SURG ORAL MED O, V80, P273, DOI 10.1016/S1079-2104(05)80382-8 COLEMAN RD, 1970, J DENT RES, V49, P626, DOI 10.1177/00220345700490032701 COPE MR, 1993, BRIT J ORAL MAX SURG, V31, P376, DOI 10.1016/0266-4356(93)90194-2 COSTEN JB, 1951, ANN OTO RHINOL LARYN, V60, P591 Costen JB, 1934, ANN OTO RHINOL LARYN, V43, P1 CROSSMAN AR, 2005, GRAYS ANATOMY ANTOMI, P436 ECKERDAL O, 1991, CRANIO, V9, P15 EMMERING TE, 1967, ORAL SURG ORAL MED O, V23, P603, DOI 10.1016/0030-4220(67)90341-6 Fernandes PRB, 2003, CRANIO, V21, P165 Gelb H, 1997, CRANIO, V15, P136 HENRY CH, 1993, J ORAL MAXIL SURG, V51, P352 HOVERSLAND R, 1996, GROSS MICROSCOPIC AN JOHANSSON AS, 1990, J ORAL MAXIL SURG, V48, P953, DOI 10.1016/0278-2391(90)90008-P KANE JW, 1978, LIFE SCI PHYS, P250 KARCHIN A, MECH PROPERTIES BIOM Koesling S, 2005, EUR J RADIOL, V54, P335, DOI 10.1016/j.ejrad.2004.09.003 KOMORI E, 1986, J CRANIOMANDIB PRACT, V4, P300 LOUGHNER BA, 1989, ORAL SURG ORAL MED O, V68, P14, DOI 10.1016/0030-4220(89)90108-4 Mahan PE, 1991, FACIAL PAIN Mercuri LG, 2003, INT J ORAL MAX SURG, V32, P353, DOI 10.1054/ijom.2002.0447 Mercuri LG, 1998, ORAL SURG ORAL MED O, V85, P631, DOI 10.1016/S1079-2104(98)90028-2 Mercuri LG, 2000, J ORAL MAXIL SURG, V58, P70, DOI 10.1016/S0278-2391(00)80020-8 Mercuri LG, 1999, CRANIO, V17, P44 Merida Velasco J. 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PD APR PY 2008 VL 26 IS 2 BP 88 EP 95 PG 8 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA 293RO UT WOS:000255352600003 PM 18468268 ER PT J AU de Felicio, CM Melchior, MDO Ferreira, CLP Da Silva, MAMR AF de Felicio, Claudia Maria Melchior, Melissa de Oliveira Pimenta Ferreira, Claudia Lucia Rodrigues Da Silva, Marco Antonio M. TI Otologic symptoms of temporomandibular disorder and effect of orofacial myofunctional therapy SO CRANIO-THE JOURNAL OF CRANIOMANDIBULAR PRACTICE LA English DT Article ID MASTICATORY MUSCLE-ACTIVITY; CRANIOMANDIBULAR DISORDERS; JOINT DISORDERS; TINNITUS; DYSFUNCTION; PREVALENCE; COMPLAINTS; OTALGIA AB The aim of this study was to investigate the frequency of otologic symptoms and their relationship to orofacial signs and symptoms of temporomandibular disorder (TMD), and the effect of orofacial myofunctional therapy. The study was conducted on eight asymptomatic subjects (Group C) and 20 subjects with articular TMD, randomly distributed over two groups: one treated using orofacial myofunctional therapy (OMT Group) and a control group with TMD (Group CTMD). Patient selection was based upon the Research Diagnostic Criteria for TMD (RDC/TMD). All subjects submitted to a clinical examination with self-reporting of symptom severity, and to orofacial myofunctional and electromyographic evaluation at diagnosis and again, at the end of the study. Correlations were calculated using the Pearson test and inter- and intragroup comparisons were made (p<0.05). In the diagnosis phase, subjects with TMD reported earache (65%), tinnitus (60%), ear fullness (90%), and 25% of the asymptomatic subjects reported tinnitus. The otologic symptoms were correlated with tenderness to palpation of the temporomandibular muscles and joints and with orofacial symptoms. Only the OMT group showed a reduction of otologic and orofacial symptoms, of tenderness to palpation and of the asymmetric index between muscles. OMT may help with muscle coordination and a remission of TMD symptoms. C1 [de Felicio, Claudia Maria; Melchior, Melissa de Oliveira; Pimenta Ferreira, Claudia Lucia; Rodrigues Da Silva, Marco Antonio M.] Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Otorrinolaringol Oftalmol & Cirurgia Cabeca, BR-14049900 Ribeirao Preto, Brazil. [Melchior, Melissa de Oliveira] Univ Sao Paulo, Dent Sch Ribeirao Preto, BR-14049900 Ribeirao Preto, Brazil. RP de Felicio, CM (reprint author), Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Otorrinolaringol Oftalmol & Cirurgia Cabeca, Av Bandeirantes 3900, BR-14049900 Ribeirao Preto, Brazil. EM cfelicio@fmrp.usp.br CR ABEKURA H, 1995, J ORAL REHABIL, V22, P747, DOI 10.1111/j.1365-2842.1995.tb00218.x Alajbeg IZ, 2003, COLLEGIUM ANTROPOL, V27, P361 ARLEN H, 1985, CLIN MANAGEMENT HEAD, P181 BALDURSSON G, 1987, EAR HEARING, V8, P63, DOI 10.1097/00003446-198704000-00001 Camparis CM, 2005, J ORAL REHABIL, V32, P808, DOI 10.1111/j.1365-2842.2005.01519.x COOPER BC, 1991, LARYNGOSCOPE, V101, P150 Dworkin Samuel F., 1992, Journal of Craniomandibular Disorders, V6, P301 FELICIO CM, 2002, CURRENT ASPECTS SPEE, P33 Felicio C M, 1991, Braz Dent J, V2, P27 Fetid CM, 2006, J CRANIOMANDIB PRACT, V24, P258 Funt LA, 1985, CLIN MANAGEMENT HEAD, P443 Greene B, 1979, DIS TEMPOROMANDIBULA, P458 HENDERSON DH, 1992, ARCH OTOLARYNGOL, V118, P1208 Keersmaekers K, 1996, J PROSTHET DENT, V75, P72, DOI 10.1016/S0022-3913(96)90421-7 Kibana Y, 2002, J ORAL REHABIL, V29, P58, DOI 10.1046/j.1365-2842.2002.00794.x KOSKINEN J, 1980, J ORAL REHABIL, V7, P249, DOI 10.1111/j.1365-2842.1980.tb00442.x Kurita H, 2001, J ORAL REHABIL, V28, P463, DOI 10.1046/j.1365-2842.2001.00688.x Lam DK, 2001, J OROFAC PAIN, V15, P146 MALKIN D P, 1987, International Journal of Orthodontics, V25, P20 MORGAN DH, 1995, CRANIO, V13, P42 NIELSEN IL, 1990, AM J ORTHOD DENTOFAC, V97, P20 Pascoal MIN, 2001, REV BRAS OTORRINOLAR, V67, P627 PENKNER K, 2000, J ORAL REHABIL, V2, P344 Peroz I, 2003, HNO, V51, P544, DOI 10.1007/s00106-002-0750-5 REN YF, 1995, CRANIO, V13, P75 Saifuddin M, 2003, J ORAL REHABIL, V30, P578, DOI 10.1046/j.1365-2842.2003.00991.x Seedorf H, 2006, LARYNGO RHINO OTOL, V85, P327, DOI 10.1055/s-2005-921052 Tuz HH, 2003, AM J ORTHOD DENTOFAC, V123, P620, DOI 10.1016/S0889-5406(03)00153-7 NR 28 TC 7 Z9 8 PU CHROMA INC PI CHATTANOOGA PA PO BOX 8887, CHATTANOOGA, TN 37414 USA SN 0886-9634 J9 CRANIO JI Cranio-J. Craniomandib. Pract. PD APR PY 2008 VL 26 IS 2 BP 118 EP 125 PG 8 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA 293RO UT WOS:000255352600006 PM 18468271 ER PT J AU Raiter, Y Farfel, A Lehavi, O Goren, OB Shamiss, A Priel, Z Koren, I Davidson, B Schwartz, D Goldberg, A Bar-Dayan, Y AF Raiter, Y. Farfel, A. Lehavi, O. Goren, O. B. Shamiss, A. Priel, Z. Koren, I. Davidson, B. Schwartz, D. Goldberg, A. Bar-Dayan, Y. TI Mass casualty incident management, triage, injury distribution of casualties and rate of arrival of casualties at the hospitals: lessons from a suicide bomber attack in downtown Tel Aviv SO EMERGENCY MEDICINE JOURNAL LA English DT Article AB Background: Terrorist attacks in Israel cause mass events with varying numbers of casualties. A study was undertaken to analyse the medical response to an event which occurred on 17 April 2006 near the central bus station, Tel Aviv, Israel. Lessons are drawn concerning the management of the event, primary triage, evacuation priorities and the rate and characteristics of casualty arrival at the nearby hospitals. Methods: Data were collected both during and after the event in formal debriefings. Their analysis refers to medical response components, interactions and main outcomes. The event is described according to the DISAST-CIR methodology ( Disastrous Incidents Systematic AnalysiS Through - Components, Interactions and Results). Results: 91 casualties were reported in this event; 85 were evacuated from the scene including 3 already dead on arrival, 9 severely injured, 14 moderately injured and 59 mildly injured. Six were declared dead at the scene. Emergency medical service ( EMS) vehicle accumulation was rapid. The casualties were distributed between five hospitals ( three level 1 and two level 2 trauma centres). The first evacuated casualty arrived at the hospital within 20 min of the explosion and the last urgent victim was evacuated from the scene after 1 h 14 min. Evacuation occurred in two phases: the first, lasting 1 h 20 min, in which most of the patients with evident trauma were evacuated and the second, lasting 8 h 15 min, in which most patients presented with tinnitus and symptoms of somatisation. The most common injuries were upper and lower limb injuries, diagnosed in 37% of the total injuries, and stress-related disturbances ( anxiety, tinnitus, somatisation) diagnosed in 41%. Conclusion: Rapid accumulation of EMS vehicles, effective primary triage between urgent and non-urgent casualties and primary distribution between five hospitals enabled rapid conclusion of the event, both at the scene and at the receiving hospitals. C1 [Lehavi, O.; Goren, O. B.] Sorasky Med Ctr, Tel Aviv, Israel. [Priel, Z.] Edith Wolfson Med Ctr, Holon, Israel. [Koren, I.] Rabin Med Ctr, Petah Tiqwa, Israel. [Davidson, B.] Asaf Harofe Hosp, Ramla, Israel. [Schwartz, D.; Goldberg, A.; Bar-Dayan, Y.] Ben Gurion Univ Negev, Fac Hlth Sci, Beer Sheva, Israel. RP Bar-Dayan, Y (reprint author), Ben Gurion Univ Negev, Fac Hlth Sci, Dept Diaster & Emergency Med, 16 Dolev St Neve Savion, Or Yehuda, Israel. EM bardayan@netvision.net.il RI schwartz, dagan/F-1938-2012 CR Almogy G, 2004, ANN SURG, V239, P295, DOI 10.1097/01.sla.0000114014.63423.55 Aylwin CJ, 2006, LANCET, V368, P2219, DOI 10.1016/S0140-6736(06)69896-6 BLOCH Y, 2007, PREHOSP DISASTER MED, V22, P176 BLOCH Y, 2007, PREHOSP DISASTER MED, V22, P171 LEIBA A, 2004, PREHOSP DISASTER MED, V20, P253 LEIBA A, 2007, J EMERG MED LEIBA A, 2004, INT J DISASTER MED, V2, P157, DOI 10.1080/15031430510034686 Leiba A, 2006, J EMERG NURS, V32, P294, DOI 10.1016/j.jen.2006.03.018 Peleg K, 2003, ADV RENAL REPLACE TH, V10, P117, DOI 10.1053/jarr.2003.50019 Pinkert M, 2007, DISASTERS, V31, P227, DOI 10.1111/j.0361-3666.2007.01006.x Schwartz Dagan, 2007, Prehosp Disaster Med, V22, P59 NR 11 TC 18 Z9 18 PU B M J PUBLISHING GROUP PI LONDON PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND SN 1472-0205 J9 EMERG MED J JI Emerg. Med. J. PD APR PY 2008 VL 25 IS 4 BP 225 EP 229 DI 10.1136/emj.2007.052399 PG 5 WC Emergency Medicine SC Emergency Medicine GA 278IT UT WOS:000254279400017 PM 18356360 ER PT J AU Safdar, A Hughes, JP Walsh, RM AF Safdar, Adnan Hughes, Joseph P. Walsh, Rory McConn TI Aberrant ectatic internal carotid artery in the middle ear SO ENT-EAR NOSE & THROAT JOURNAL LA English DT Article ID VASCULAR ANOMALIES AB We report the case of a 34-year-old man with pulsatile tinnitus and a reddish mass in the anteroinferior quadrant of the middle ear. Physical examination and imaging were unable to establish a diagnosis, so an exploratory tympanotomy was performed. Exploration revealed the presence of an ectatic aberrant internal carotid artery in the middle ear. Aberrations of the internal carotid artery in the middle ear are rare. Even so, our case is unusual in that all initial investigations had failed to establish the diagnosis. This case highlights the limitations of modern imaging techniques in certain situations. C1 [Safdar, Adnan; Hughes, Joseph P.; Walsh, Rory McConn] Beaumont Hosp, Dept Otolaryngol Head & Neck Surg, Dublin 9, Ireland. RP Safdar, A (reprint author), 4 Sir Kenneth Luke Blvd, Mulgrave, Vic 3170, Australia. EM adnan_Safdar@hotmail.com CR ANAND VK, 1991, OTOLARYNG HEAD NECK, V105, P743 BOLD EL, 1994, LARYNGOSCOPE, V104, P1404 GLASSCOCK ME, 1980, LARYNGOSCOPE, V90, P77, DOI 10.1288/00005537-198001000-00009 Hunt JT, 2000, AM J OTOLARYNG, V21, P50, DOI 10.1016/S0196-0709(00)80125-8 LAPAYOWK.MS, 1971, RADIOLOGY, V98, P293 MAKOW LS, 1989, RADIOL CLIN N AM, V27, P195 MCELVEEN JT, 1986, OTOLARYNG HEAD NECK, V94, P616 Miller S, 1997, CAN ASSOC RADIOL J, V48, P33 Myerson MC, 1934, ARCHIV OTOLARYNGOL, V20, P195 PIRODDA A, 1994, J LARYNGOL OTOL, V108, P237 REMLEY KB, 1990, RADIOLOGY, V174, P383 RUGGLES RL, 1972, LARYNGOSCOPE, V82, P1199, DOI 10.1288/00005537-197207000-00008 SINNREICH AI, 1984, OTOLARYNG HEAD NECK, V92, P194 STEFFEN TN, 1968, LARYNGOSCOPE, V78, P171, DOI 10.1288/00005537-196802000-00001 NR 14 TC 3 Z9 3 PU VENDOME GROUP LLC PI NEW YORK PA 149 FIFTH AVE, 10TH FLOOR, NEW YORK, NY 10010 USA SN 0145-5613 J9 ENT-EAR NOSE THROAT JI ENT-Ear Nose Throat J. PD APR PY 2008 VL 87 IS 4 BP 214 EP 216 PG 3 WC Otorhinolaryngology SC Otorhinolaryngology GA 286ZW UT WOS:000254886800012 PM 18478795 ER PT J AU Guevara, N Deveze, A Buza, V Laffont, B Magnan, J AF Guevara, Nicolas Deveze, Arnaud Buza, Valeriu Laffont, Benoit Magnan, Jacques TI Microvascular decompression of cochlear nerve for tinnitus incapacity: pre-surgical data, surgical analyses and long-term follow-up of 15 patients SO EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY LA English DT Article DE tinnitus; surgery; microvascular decompression; cochleovestibular compression syndrome ID SURGERY; ENDOSCOPY; SYMPTOMS AB The level of success of neurovascular decompression in ponto-cerebellar angle for hemifacial spasm and trigeminal neuralgia has already established the reality of the pathology to explain such symptoms. However, cochlear nerve compression syndrome by vascular loop is still a controversial topic. We have performed a retrospective cases review with long-term follow-up (5-7 years) concerning the results of microvascular decompression surgery of the cochlear nerve via an endoscopy assisted retrosigmoid approach on 15 patients suffering from unilateral incapacitating tinnitus with abnormal auditory brainstem response and an offending vessel on magnetic resonance imaging. During the surgery, a vascular compression was found on every patient. In a long-term follow-up, 53.3% (8 cases) of our tinnitus cases improved and 20% (3 cases) of them were completely cured. The ABR returned to normal in all patients who had good clinical results (diminished or disappeared tinnitus). When a vertebral artery loop (5 cases) was concerned we obtained 80% of good clinical results. No one showed amelioration or sudden aggravation of their hearing. Three cases required surgical correction of cerebrospinal fluid leak and one case developed spontaneously regressive swallowing problems. Such microvascular decompression surgery of the cochlear nerve appears to be successful in treating incapaciting tinnitus in particular when a vertebral artery loop is observed. Therefore, in such a case, one might recommend neurovascular decompression surgery, keeping in mind that the complications of this surgery should be minimized by a careful closure of the retrosigmoid approach. In order to ensure a better selection of patient more accurate cochlear nerve monitoring and functional MRI should be a promising assessment. C1 [Guevara, Nicolas] Hop Louis Pasteur, CHU Nice, Dept Otorhinolaryngol, F-06002 Nice, France. [Deveze, Arnaud; Buza, Valeriu; Laffont, Benoit; Magnan, Jacques] CHU Nord, Dept Otorhinolaryngol, Marseille, France. RP Guevara, N (reprint author), Hop Louis Pasteur, CHU Nice, Dept Otorhinolaryngol, 30 Ave de la Voie Romaine,BP 69, F-06002 Nice, France. EM guevara.n@chu-nice.fr RI DEVEZE, Arnaud/J-7903-2012 CR Adams CBT, 1989, J NEUROSURG, V57, P1 Badr-El-Dine M, 2002, OTOL NEUROTOL, V23, P122, DOI 10.1097/00129492-200203000-00002 Brookes GB, 1996, AM J OTOL, V17, P569 El-Garem HF, 2002, OTOL NEUROTOL, V23, P132, DOI 10.1097/00129492-200203000-00004 LANG J, 1981, CRANIAL NERVES, P363 Legatt AD, 2002, J CLIN NEUROPHYSIOL, V19, P396, DOI 10.1097/00004691-200210000-00003 Makins AE, 1998, LARYNGOSCOPE, V108, P1739, DOI 10.1097/00005537-199811000-00027 Melcher JR, 2000, J NEUROPHYSIOL, V83, P1058 MOLLER AR, 1992, LARYNGOSCOPE, V102, P187 MOLLER MB, 1993, LARYNGOSCOPE, V103, P421 Okamura T, 2000, J NEUROSURG, V93, P421, DOI 10.3171/jns.2000.93.3.0421 Ryu H, 1998, ACTA NEUROCHIR, V140, P1279, DOI 10.1007/s007010050250 Vasama JPI, 1998, NEUROL RES, V20, P242 Wackym PA, 2002, OTOLARYNG CLIN N AM, V35, P297, DOI 10.1016/S0030-6665(02)00015-4 Weissman JL, 2000, RADIOLOGY, V216, P342 NR 15 TC 18 Z9 22 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013 USA SN 0937-4477 J9 EUR ARCH OTO-RHINO-L JI Eur. Arch. Oto-Rhino-Laryn. PD APR PY 2008 VL 265 IS 4 BP 397 EP 401 DI 10.1007/s00405-007-0471-1 PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA 268HM UT WOS:000253570900004 PM 17909826 ER PT J AU Pajor, A Jozefowicz-Korczynska, M AF Pajor, Anna Jozefowicz-Korczynska, Magdalena TI Prognostic factors for vestibular impairment in sensorineural hearing loss SO EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY LA English DT Article DE sensorineural hearing loss; vestibular impairment; electronystagmography; prognostic factors ID VERTIGO; DEAF AB The clinical course and prognosis in sensorineural hearing loss (SNHL) may be even worse if vestibular system is also involved, especially due to near location of anatomical structures in the inner ear. The aim of the study was to determine prognostic value of some clinical, audiological and demographic factors associated with SNHL in predicting a possibility of vestibular impairment. The study was conducted on 124 consecutive patients (183 ears) diagnosed for sensorineural hearing loss during 1 year in our department. In all of them, audiological (pure-tone, speech and impedance audiometry, ABR) and ENG examinations (visual ocular-motor, positional, kinetic and caloric tests) were performed. The correlations between ENG outcome and the following variables associated with sensorineural hearing loss were investigated: audiological (degree and location of hearing loss, audiogram configuration), clinical (tinnitus, vertigo, dizziness) and demographic (age, sex) factors. Normal ENG was recorded in 26.6%, vestibular impairment of peripheral type in 38.7%, and central type in 34.7% of the patients. In a multivariate stepwise linear regression analysis, the degree of hearing loss was the main variable correlating with abnormal ENG result. Tinnitus and location of hearing loss were also found to be the two other variables which, to some minor extent, can influence the ENG outcome. Peripheral vestibular impairment was observed more frequently in patients with residual hearing/deafness. The degree of hearing loss, presence of tinnitus and location of hearing loss are factors predicting the possibility of abnormal ENG outcome in sensorineural hearing loss. C1 [Pajor, Anna; Jozefowicz-Korczynska, Magdalena] Barlicki Univ Hosp, Med Univ Lodz, Dept Otolaryngol, PL-90153 Lodz, Poland. RP Pajor, A (reprint author), Barlicki Univ Hosp, Med Univ Lodz, Dept Otolaryngol, PL-90153 Lodz, Poland. 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Arch. Oto-Rhino-Laryn. PD APR PY 2008 VL 265 IS 4 BP 403 EP 407 DI 10.1007/s00405-007-0473-z PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA 268HM UT WOS:000253570900005 PM 17926054 ER PT J AU Mlynski, R Radeloff, A Brunner, K Hagen, R AF Mlynski, R. Radeloff, A. Brunner, K. Hagen, R. TI Exostoses of the external auditory canal SO HNO LA German DT Article DE exostoses; external auditory meatus; complication; water sport; surgical procedure ID COLD-WATER; SURFERS EAR; PREVALENCE; DIVERS AB Introduction. Exostoses of the external auditory meatus are benign masses of tympanal bone that can lead to infections of the external auditory meatus in advanced cases and then need surgical treatment. Regular irritation of the auditory meatus by exposure to cold water was implicated in the causation of exostoses long ago. The present study investigates the cold water hypothesis in a patient group of continental origin. The surgical procedures and results are discussed. Study design. Retrospective study. Materials and methods. We present the epidemiological and aetiological data and postoperative findings recorded for 144 patients (167 procedures) who underwent surgical removal of exostoses from the external auditory meatus in the hospital in Wurzburg within 11 years. In attempt to glean further information about the aetiology, patients were also asked to complete a questionnaire on participation in water sports and their symptoms before and since the operation. Results. Most of the patients (94%) had taken part in water sports for some years, more than 80% of them several times weekly. The most common indication for surgical removal was recurrent infection of the external ear. Although 50% of the patients reported improved hearing, no higher sound threshold was observed. Reversible complications (ear drum performation, tinnitus, opening of mastoid cells) were observed in 18% of the patients. One patient had a stenosis of the auditory canal caused by scar tissue. Conclusions. Surgical removal of exostoses in the external auditory canal is frequently fraught with controllable complications. The indications for their surgical removal should be strictly applied; the presence of exostoses in isolation is not an acceptable indication for surgery. Removal of exostoses is an adequate way of avoiding recurrent external ear infections. Improved hearing can be expected only if the self-cleaning function of the external auditory meatus is improved. C1 [Mlynski, R.; Radeloff, A.; Brunner, K.; Hagen, R.] Univ Wurzburg, Klin & Poliklin Hals Nasen & Ohrenkrankheiten Pla, Klinikum Bayer, D-97080 Wurzburg, Germany. RP Mlynski, R (reprint author), Univ Wurzburg, Klin & Poliklin Hals Nasen & Ohrenkrankheiten Pla, Klinikum Bayer, Josef Schneider Str 11, D-97080 Wurzburg, Germany. 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Fetter, M. Albert, F. K. TI Vestibular paroxysmia SO HNO LA German DT Article DE vertigo; tinnitus; paroxysmia; trigeminal neuralgia; microvascular decompression ID DISABLING POSITIONAL VERTIGO; MICROVASCULAR DECOMPRESSION; NEUROVASCULAR COMPRESSION; TRIGEMINAL NEURALGIA; 8TH NERVE; BLIND AB The diagnosis and treatment of vertigo are very common in ear nose and throat medicine and neurology. As our case report demonstrates, an interdisciplinary approach is often useful for finding the correct diagnosis. Diagnosing disabling positional vertigo now seems uncomplicated using special MRI. More important is the history of frequent, short-term vertigo, sometimes accompanied by tinnitus. In analogy to trigeminal neuralgia, treatment should be started with carbamazepine or similar drugs. If unsuccessful, microvascular decompression as a neurosurgical intervention is recommended. C1 [Reuter, W.] Praxis HNO & Phoniatr Padaudiol, D-59555 Lippstadt, Germany. [Fetter, M.] Zentrum Neurol & Fruhrehabil, Karlsbad, Germany. [Albert, F. K.] Paracelsus Klin, Med Zentrum Neurochirurg & Neurol, Osnabruck, Germany. RP Reuter, W (reprint author), Praxis HNO & Phoniatr Padaudiol, Woldemei 16, D-59555 Lippstadt, Germany. EM info@hno-lippstadt.de CR Anderson VC, 2006, NEUROSURGERY, V58, P666, DOI 10.1227/01.NEU.0000197117.34888.DE Benes L, 2005, NEUROSURG REV, V28, P131, DOI 10.1007/s10143-004-0372-3 Brackmann DE, 2001, OTOL NEUROTOL, V22, P882, DOI 10.1097/00129492-200111000-00029 De Ridder D, 2004, NEUROSURGERY, V54, P381, DOI 10.1227/01.NEU.0000103420.53487.79 Ernst A, 2006, OTOLARYNG HEAD NECK, V135, P286, DOI 10.1016/j.otohns.2006.03.006 JANETTA JJ, 1993, BRAIN SURG COMPLICAT, P2085 MOLLER MB, 1990, ANN OTO RHINOL LARYN, V99, P724 MOLLER MB, 1993, ACTA NEUROCHIR, V125, P75, DOI 10.1007/BF01401831 Okamura T, 2000, J NEUROSURG, V93, P421, DOI 10.3171/jns.2000.93.3.0421 NR 9 TC 1 Z9 2 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013 USA SN 0017-6192 J9 HNO JI HNO PD APR PY 2008 VL 56 IS 4 BP 421 EP 424 DI 10.1007/s00106-006-1535-z PG 4 WC Otorhinolaryngology SC Otorhinolaryngology GA 285DF UT WOS:000254756800010 PM 17333041 ER PT J AU Mazurek, B Stover, T Haupt, H Gross, J Szczepek, A AF Mazurek, B. Stoever, T. Haupt, H. Gross, J. Szczepek, A. TI Pathogenesis and treatment of presbyacusis SO HNO LA German DT Article DE presbyacusis; hypoxia; ischemia; free radicals; mitochondria; therapy ID MITOCHONDRIAL-DNA MUTATIONS; HEARING-LOSS; AUDITORY-SYSTEM; NEWBORN RAT; HAIR-CELLS; INNER-EAR; PRESBYCUSIS; COCHLEA; RESTRICTION; MECHANISMS AB Factors responsible for presbyacusis include physiological ageing processes as well as endogenous or exogenous causes. In the industrial countries, two main exogenous causes are exposure to loud noise and obesity. Pathomechanisms contributing to presbyacusis are hypoxia/ischemia, reactive species formation and oxidative stress, apoptotic and necrotic death of hair cells and spiral ganglion cells as well as inherited and acquired mutations in the mitochondrial DNA. Important for the successful treatment of presbyacusis is a timely fitting of hearing aids on both ears to improve communication and provide the auditory system with acoustic information. Using the hearing aids will also elevate the detection threshold of an existing tinnitus signal. At present, several therapeutic strategies based on pharmacological intervention are under discussion. The application of antioxidants or caloric restriction are considered to prevent or reduce oxidative stress-induced damage. Animal experiments evidenced that superoxide dismutase 2 (SOD2) strongly decreases in age; thus, a further approach may be the overexpression or modulation of the SOD2 within the cochlea. Adenoviral-mediated gene transfer technology would be a tempting approach to address this type of therapy. Finally, hair cell regeneration could be a possible treatment of presbyacusis in the future. C1 [Mazurek, B.; Gross, J.; Szczepek, A.] Charite Univ Med Berlin, HNO Klin & Poliklin, Tinnituszentrum & Mol Biol Forsch Labor, D-10117 Berlin, Germany. [Stoever, T.] Hannover Med Sch, HNO Klin & Poliklin, Hannover, Germany. RP Mazurek, B (reprint author), Charite Univ Med Berlin, HNO Klin & Poliklin, Tinnituszentrum & Mol Biol Forsch Labor, Campus Charite Mitte,Charitepl 1, D-10117 Berlin, Germany. 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Although research shows that industrial workers have a higher propensity to noise-induced hearing loss, musicians can also develop a hearing loss from noise exposure. Furthermore, musicians can suffer from tinnitus, hyperacusis, and distortion, among other hearing disorders, which can affect their work more severely than a hearing loss. This study investigated the use of hearing protectors, the prevalence of self-reported hearing disorders among musicians, and the importance of these hearing disorders to the musicians. The musicians at three Danish symphony orchestras were asked to complete a questionnaire on the topic. Results showed that Danish musicians are aware of the dangers of loud music, yet they rarely use hearing protectors and not always correctly; however, musicians with hearing disorders use hearing protectors more frequently. In addition, the musicians questioned suffered from different hearing disorders. Education is needed to change musicians' opinion of hearing conservation and hearing protectors. The education must be directed to both the musicians and the administration of the symphony orchestras. C1 [Laitinen, Heli] Heikki Helimaki Ltd, Engn Off, Helsinki 00100, Finland. [Poulsen, Torben] Tech Univ Denmark, DTU Elect Engn, Lyngby, Denmark. RP Laitinen, H (reprint author), Heikki Helimaki Ltd, Engn Off, Temppelikatu 6 B, Helsinki 00100, Finland. 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TI Topical review: Temporomandibular disorders in an integral otic symptom model SO INTERNATIONAL JOURNAL OF AUDIOLOGY LA English DT Review DE temporomandibular disorders; tinnitus; otic fullness; vertigo; otalgia; subjective hearing loss; tensor tympani; tensor veli palatini ID TENSOR VELI-PALATINI; DORSAL COCHLEAR NUCLEUS; PAIN-DYSFUNCTION SYNDROME; CERVICAL-SPINE DISORDERS; EUSTACHIAN-TUBE DYSFUNCTION; LATERAL PTERYGOID MUSCLE; 3-YEAR FOLLOW-UP; JOINT DYSFUNCTION; MIDDLE-EAR; AURAL SYMPTOMS AB The literature has closely observed otic symptoms (and other craniofacial complaints) in temporomandibular disorders; however, there is little evidence for an association between the two. This review tries to provide an integrated biological basis for otic symptoms in temporomandibular disorders from both anatomical and physiological points of view; it also attempts to enlarge the view of one of the ranges of central and peripheral mechanisms involved. The pathophysiology of common symptoms is integrated within different health specialties through basic science. This review is not based on a structured selection of randomized controlled trials; rather, it deals with perspectives of otic symptoms triggered or exacerbated by stomatognathic dynamics. C1 [Ramirez, L. M.; Ballesteros, L. E.] Univ Ind Santander, Dept Basic Sci, Fac Med, Bucaramanga, Colombia. [Sandoval, G. P.] Univ Ind Santander, Dept Surg, Fac Med, Bucaramanga, Colombia. RP Ramirez, LM (reprint author), Calle 45 N 33-17,Edificio La Nacl Apto 702B, Bucaramanga, Colombia. 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J. Audiol. PD APR PY 2008 VL 47 IS 4 BP 215 EP 227 DI 10.1080/14992020701843137 PG 13 WC Audiology & Speech-Language Pathology; Otorhinolaryngology SC Audiology & Speech-Language Pathology; Otorhinolaryngology GA 293NA UT WOS:000255340800009 PM 18389418 ER PT J AU Mallur, PS Wisoff, JH Lalwani, AK AF Mallur, Pavan S. Wisoff, Jeffrey H. Lalwani, Anil K. TI Steroid responsive fluctuating sensorineural hearing loss due to juvenile pilocytic astrocytoma involving the cerebellopontine angle SO INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY LA English DT Article DE steroid responsive hearing toss; juvenile pilocytic astrocytoma; cerebellopontine angle; otoacoustic emission test ID LESIONS; TUMORS AB Tumors of the cerebellopontine angle (CPA) are common and represent up to 10% of all intracranial tumors. Rarely, intrinsic brainstem tumors can involve the CPA and present with auditory symptoms typical of CPA tumors such as hearing loss, vertigo and tinnitus. We report on a rare case of an intrinsic brainstem neoplasm presenting with steroid responsive fluctuating sensorineural hearing loss in a child. The patient initially presented with an acute worsening of an unilateral sensorineural hearing toss, without additional symptoms, that responded to oral steroids. Otoacoustic emission testing demonstrated normal outer hair cell function suggesting retrocochlear pathology. Magnetic resonance imaging with contrast enhancement revealed an intrinsic neoplasm of the middle cerebellar peduncle impinging on the 7th/8th neurovascular bundle within the CPA. The patient underwent gross total resection of the juvenile pilocytic astrocytoma via retrosigmoid craniotomy and remains disease free at 2 years postoperatively. This case highlights that suspicion of central nervous system pathology should be heightened in the presence of steroid responsive, fluctuating sensorineural hearing loss with normal outer hair cell function. (c) 2008 Elsevier Ireland Ltd. All rights reserved. C1 [Mallur, Pavan S.; Lalwani, Anil K.] NYU, Sch Med, Dept Otolaryngol, New York, NY 10016 USA. [Wisoff, Jeffrey H.] NYU, Sch Med, Dept Neurosurg, New York, NY 10016 USA. RP Lalwani, AK (reprint author), NYU, Sch Med, Dept Otolaryngol, 550 1st Ave,NBV 5E5, New York, NY 10016 USA. EM anil.lalwani@nyumc.org CR Ahn MS, 1997, LARYNGOSCOPE, V107, P466, DOI 10.1097/00005537-199704000-00008 ARNAUTOVIC KI, 2000, J NEUROONCOL, V29, P205 BEUTLER AS, 1995, NEUROSURGERY, V37, P125 Bonneville F, 2001, RADIOGRAPHICS, V21, P419 Jackler RK, 2005, NEUROTOLOGY MOFFAT DA, 1993, J LARYNGOL OTOL, V107, P1087 Rapin I, 2003, INT J PEDIATR OTORHI, V67, P707, DOI 10.1016/S0165-5876(03)00103-4 NR 7 TC 2 Z9 2 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0165-5876 J9 INT J PEDIATR OTORHI JI Int. J. Pediatr. Otorhinolaryngol. PD APR PY 2008 VL 72 IS 4 BP 529 EP 534 DI 10.1016/j.ijport.2007.12.010 PG 6 WC Otorhinolaryngology; Pediatrics SC Otorhinolaryngology; Pediatrics GA 284SB UT WOS:000254725000012 PM 18255162 ER PT J AU Choi, JH Cho, YM Suh, KS Yoon, HR Kim, GH Kim, SS Ko, JM Lee, JH Park, YS Yoo, HW AF Choi, Jin-Ho Cho, Young Mi Suh, Kwang-Sun Yoon, Hye-Ran Kim, Gu-Hwan Kim, Sung-Su Ko, Jung Min Lee, Joo Hoon Park, Young Seo Yoo, Han-Wook TI Short-term efficacy of enzyme replacement therapy in Korean patients with Fabry disease SO JOURNAL OF KOREAN MEDICAL SCIENCE LA English DT Article DE alpha-galactosidase A; enzyme replacement therapy; Fabry disease; globotriaosylceramide; lysosomal storage diseases ID LYSOSOMAL STORAGE DISORDERS; ALPHA-GALACTOSIDASE; CLINICAL-MANIFESTATIONS; AGALSIDASE-ALPHA; MUTATIONS; SAFETY; GLOBOTRIAOSYLCERAMIDE; IDENTIFICATION; FAMILIES; CHILDREN AB Fabrazyme has been widely used for treatment of Fabry disease since its approval by the U.S. Food and Drug Administration in 2003. This study was undertaken to assess the short-term efficacy and safety of enzyme replacement therapy (ERT) for Fabry disease in Korea. Eight male patients and three female symptomatic carriers aged 13 to 48 yr were included. Fabrazyme was administered by intravenous infusion at a dose of 1 mg/kg every 2 weeks. Plasma and urine globotriaosylceramide (GL-3) levels, serum creatinine, creatinine clearance, and 24-hr urine protein levels were measured every 3 months. Kidney biopsies, ophthalmologic exams, and pure tone audiometry were performed before and 1 yr after ERT. Kidney function, including serum creatinine, creatinine clearance, and the 24-hr urine protein level, remained stable during ERT. Plasma and urine GL-3 levels were reduced within 3 to 6 months of ERT initiation. Microvascular endothelial deposits of GL-3 were decreased from renal biopsy specimens after 1 yr of treatment. The severity of sensorineural hearing loss and tinnitus did not improve after ERT. ERT is safe and effective in stabilizing renal function and clearing microvascular endothelial GL-3 from kidney biopsy specimen in Korean patients with Fabry disease. C1 [Choi, Jin-Ho] Chungnam Natl Univ, Chungnam Natl Univ Hosp, Res Inst Med Sci, Dept Pediat,Coll Med, Taejon, South Korea. [Cho, Young Mi] Chungnam Natl Univ, Chungnam Natl Univ Hosp, Res Inst Med Sci, Dept Pathol,Coll Med, Taejon, South Korea. [Kim, Gu-Hwan; Kim, Sung-Su; Yoo, Han-Wook] Univ Ulsan, Coll Med, Asan Med Ctr, Dept Pediat, Seoul 138736, South Korea. [Suh, Kwang-Sun] Univ Ulsan, Coll Med, Asan Med Ctr, Dept Pathol, Seoul 138736, South Korea. [Yoon, Hye-Ran] Univ Ulsan, Coll Med, Asan Med Ctr, Med Genet Clin & Lab, Seoul 138736, South Korea. [Ko, Jung Min; Lee, Joo Hoon; Park, Young Seo; Yoo, Han-Wook] Duksung Womens Univ, Sch Pharm, Dept Analyt Chem, Biomed & Pharmaceut Anal Lab, Seoul, South Korea. RP Yoo, HW (reprint author), Univ Ulsan, Coll Med, Asan Med Ctr, Dept Pediat, 388-1 Pungnap Dong, Seoul 138736, South Korea. 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Korean Med. Sci. PD APR PY 2008 VL 23 IS 2 BP 243 EP 250 DI 10.3346/jkms.2008.23.2.243 PG 8 WC Medicine, General & Internal SC General & Internal Medicine GA 302KP UT WOS:000255967500012 PM 18437007 ER PT J AU Zhang, J Guan, Z AF Zhang, Jinsheng Guan, Zhenlong TI Modulatory effects of somatosensory electrical stimulation on neural activity of the dorsal cochlear nucleus of hamsters SO JOURNAL OF NEUROSCIENCE RESEARCH LA English DT Article DE tinnitus suppression; somatosensory; electrical stimulation; spontaneous activity; dorsal cochlear nucleus ID METABOTROPIC GLUTAMATE RECEPTORS; PARALLEL FIBER STIMULATION; HIGH-INTENSITY SOUND; TINNITUS SUPPRESSION; BRAIN-STEM; INFERIOR COLLICULUS; AUDITORY-CORTEX; HEARING-LOSS; RAT; NEURONS AB The effects of somatosensory electrical stimulation on the dorsal cochlear nucleus (DCN) activity of control and tone-exposed hamsters were investigated. One to three weeks after sound exposure and control treatment, multiunit activity was recorded at the surface of the left DCN before, during, and after electrical stimulation of the basal part of the left pinna. The results demonstrated that sound exposure induced hyperactivity in the DCN. In response to electrical stimulation, neural activity in the DCN of both control and exposed animals manifested four response types: S-S, suppression occurring during and after stimulation; E-S, excitation occurring during stimulation and suppression after; S-E, suppression occurring during stimulation and excitation after; and E-E, excitation occurring during and after stimulation. The results showed that there was a higher incidence of suppressive (up to 70%) than of excitatory responses during and after stimulation in both groups. In addition, there was a significantly higher degree of suppression after, rather than during stimulation. At high levels of electrical current, the degree of the induced suppression was generally higher during and after stimulation in exposed animals than in controls. The similarity of our results to those of previous clinical studies further supports the view that DCN hyperactivity is a direct neural correlate of tinnitus and that somatosensory electrical stimulation can be used to modulate DCN hyperactivity. Optimization of stimulation strategy through activating only certain neural pathways and applying appropriate stimulation parameters may allow somatosensory electrical stimulation to be used as an effective tool for tinnitus suppression. (C) 2007 Wiley-Liss, Inc. C1 [Zhang, Jinsheng; Guan, Zhenlong] Wayne State Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, Lab Aud Prostheses Res, Detroit, MI 48201 USA. [Zhang, Jinsheng] Wayne State Univ, Coll Liberal Arts & Sci, Dept Commun Sci & Disorders, Detroit, MI USA. [Guan, Zhenlong] Hebei Normal Univ Coll Life Sci, Dept Zool, Shijiazhuang, Hebei, Peoples R China. RP Zhang, J (reprint author), Wayne State Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, Lab Aud Prostheses Res, 5E-UHC,4201 St Antoine, Detroit, MI 48201 USA. 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Neurosci. Res. PD APR PY 2008 VL 86 IS 5 BP 1178 EP 1187 DI 10.1002/jnr.21560 PG 10 WC Neurosciences SC Neurosciences & Neurology GA 284QD UT WOS:000254720000022 PM 17975829 ER PT J AU Ami, M Abdullah, A Awang, MA Liyab, B Saim, L AF Ami, Mazita Abdullah, Asma Awang, Mahamad A. Liyab, Borhan Saim, Lokman TI Relation of Distortion Product Otoacoustic Emission With Tinnitus SO LARYNGOSCOPE LA English DT Article; Proceedings Paper CT 26th Annual Meeting of the Malaysian-Society-of-Otorhinolaryngologist-Head-Neck-Surgeons CY MAY 26-28, 2006 CL Langkawi, MALAYSIA SP Malaysian Soc Othorhinolaryngol Head & Neck Surg DE Tinnitus; distortion product otoacoustic emission; outer hair cell ID HEARING SUBJECTS; NOISE EXPOSURE; DPOAE; MECHANISMS; TRAUMA AB Objective: To investigate cochlear outer hair cell function based on distortion product otoacoustic emission (DPOAE) in patients with tinnitus. Study Design: This is a case control study. Subjects and Methods: The subjects are patients who attended the Otorhinolaryngology Clinic in Hospital Universiti Kebangsaan Malaysia over a period of 19 months from April 2005 until. October 2006. All patients underwent a full ENT assessment and had tympanometry, pure tone audiometry, and DPOAE tests. The UKM Research and Ethics Committee reviewed and approved the study proposal prior to commencement of this study. Results: The study population included 49 patients. They consisted of 16 patients (32 ears) with tinnitus and reduced hearing, 13 patients (26 ears) with tinnitus and normal hearing, 7 patients (13 ears) without tinnitus with reduced hearing, and 13 patients (26 ears) without tinnitus with normal hearing. Statistical analysis showed significant differences (P =.00) of mean DPOAE levels between the four groups of patients. Conclusion: Our results suggest that reduced outer hair cell activity, as detected by reduced DPOAE levels, may manifest as tinnitus even before there is a shift on hearing threshold. We also postulate that further reduction of cochlear outer hair cell activity, as shown by further reduced DPOAE levels, may actually terminate the source of tinnitus. C1 [Ami, Mazita; Abdullah, Asma; Liyab, Borhan; Saim, Lokman] Univ Kebangsaan Malaysia, Fac Med, Dept ORL HNS, Kuala Lumpur 56000, Malaysia. [Awang, Mahamad A.] Univ Kebangsaan Malaysia, Fac Med, Dept Med Rehabil Serv, Kuala Lumpur 56000, Malaysia. RP Ami, M (reprint author), Univ Kebangsaan Malaysia, Fac Med, Dept ORL HNS, Kuala Lumpur 56000, Malaysia. 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Pharmacol. PD APR PY 2008 VL 73 IS 4 BP 1085 EP 1091 DI 10.1124/mol.107.041814 PG 7 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA 275IK UT WOS:000254064900006 PM 18198284 ER PT J AU Tsutsumi, S Yasumoto, Y Ito, M Oishi, H Arai, H AF Tsutsumi, Satoshi Yasumoto, Yukimasa Ito, Masanori Oishi, Hidenori Arai, Hajime TI Posterior fossa dural arteriovenous fistula as a probable cause of congestive myelopathy - Case report SO NEUROLOGIA MEDICO-CHIRURGICA LA English DT Article DE arteriovenous fistula; venous congestive myelopathy; spinal infarction ID PERIMEDULLARY VENOUS DRAINAGE; FOIX-ALAJOUANINE-SYNDROME; ANTERIOR CONDYLAR VEIN; DIFFUSE MR ENHANCEMENT; BRAIN-STEM INFARCTION; SPINAL-CORD; CERVICAL MYELOPATHY AB A 62-year-old female suffered severe occipitalgia followed by progressive tetraparesis and bulbar symptoms, although tinnitus in the left ear persisting for more than 1 year resolved spontaneously after the onset. Cerebral magnetic resonance (MR) imaging revealed swelling in the lower brainstem, and cervical T-2-weighted MR imaging showed diffuse intramedullary hyperintensity in the medulla oblongata extending downward to the upper thoracic cord. Rim-like enhancement was localized at the C2 level after gadolinium administration. Extensive blood and cerebrospinal fluid examinations and whole body scintigraphy showed no indications of the underlying pathology. She underwent open biopsy for histological verification and decompressive maneuver to the cord. Sparse arterial distribution, and collapsed and partially thrombosed veins were recognized on the dorsal surface of the cord. Midline myelotomy yielded creamy fluid that proved to be necrotic tissue. Histological examination found the venous wall was thickened with lymphocytic infiltration. Her tetraparesis showed mild improvement postoperatively with marked resolution of the intramedullary hyperintensity on MR imaging. Postoperative cerebral angiography revealed a posterior fossa dural arteriovenous fistula (dAVF) fed by the left ascending pharyngeal and occipital arteries, with venous reflux to the ipsilateral inferior petrosal sinus. No venous drainage was found via the perimedullary vein. The dAVF was completely obliterated by transvenous coil embolization. We considered that the dAVF might have caused the congestive myelopathy. Decompressive maneuver may provide effective management for necrotizing myelopathy in selected cases. C1 [Tsutsumi, Satoshi; Yasumoto, Yukimasa; Ito, Masanori] Juntendo Univ, Urayasu Hosp, Dept Neurol Surg, Chiba 2790021, Japan. [Oishi, Hidenori; Arai, Hajime] Juntendo Univ Hosp, Dept Neurol Surg, Tokyo, Japan. RP Tsutsumi, S (reprint author), Juntendo Univ, Urayasu Hosp, Dept Neurosurg, 2-1-1 Tomioka, Chiba 2790021, Japan. 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Med.-Chir. PD APR PY 2008 VL 48 IS 4 BP 171 EP 175 DI 10.2176/nmc.48.171 PG 5 WC Clinical Neurology; Surgery SC Neurosciences & Neurology; Surgery GA 290GM UT WOS:000255111300005 PM 18434696 ER PT J AU Figueiredo, RR Langguth, B de Oliveira, PM de Azevedo, AA AF Figueiredo, Ricardo Rodrigues Langguth, Berthold de Oliveira, Patricia Mello de Azevedo, Andreia Aparecida TI Tinnitus treatment with memantine SO OTOLARYNGOLOGY-HEAD AND NECK SURGERY LA English DT Article ID PHANTOM LIMB PAIN; RECEPTOR ANTAGONIST; COCHLEA; TRIAL AB OBJECTIVE: To evaluate efficacy and safety of memantine in the treatment of tinnitus. STUDY DESIGN: Prospective, randomized, double-blind crossover study. SUBJECTS AND METHODS: A total of 60 patients with tinnitus were randomized into a double-blind, placebo-controlled, prospective crossover study. Patients each received up to 20 mg memantine and placebo for 90 days, separated by a 30-day wash- out period. Treatment effects were assessed by using the Tinnitus Handicap Inventory (THI). A total of 43 patients completed the trial. RESULTS: There was no sianificant improvement of THI score after memantine treatment compared with placebo. A possible tendency for delayed effects of memantine was observed. The incidence of side effects during memantine treatment was 9.4 percent, leading to interruption of treatment in all cases. CONCLUSION: This study does not provide evidence to recommend memantine for the treatment of tinnitus. A possible late effect of the drug should be evaluated in further studies with longer observation periods. (C) 2008 American Academy of Otolaryngology-Head and Neck Surgery Foundation. All rights reserved. C1 [Langguth, Berthold] Univ Regensburg, Dept Psychiat, D-8400 Regensburg, Germany. RP Figueiredo, RR (reprint author), Rue 60,N 1680,AP 202, BR-27261130 Volta Redonda, RJ, Brazil. 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Otorrinolaringol., V71, P618, DOI 10.1590/S0034-72992005000500012 CIESTREICHER E, 1998, ORL J OTORHINOLARYNG, V60, P18 DENK DM, 1997, ACTA OTO-LARYNGOL, V117, P827 Guitton MJ, 2003, J NEUROSCI, V23, P3944 Lobarinas E, 2006, Acta Otolaryngol Suppl, P13 Maier C, 2003, PAIN, V103, P277, DOI 10.1016/S0304-3959(02)00456-6 Merello M, 1999, CLIN NEUROPHARMACOL, V22, P273 Moller AR, 1997, AM J OTOL, V18, P577 Muhlnickel W, 1998, P NATL ACAD SCI USA, V95, P10340, DOI 10.1073/pnas.95.17.10340 Oestreicher E, 2002, ADV OTO-RHINO-LARYNG, V59, P18 PUJOL R, 1993, ACTA OTO-LARYNGOL, V113, P330, DOI 10.3109/00016489309135819 Salembier L, 2006, Acta Otolaryngol Suppl, P93 Weisz N, 2007, J NEUROSCI, V27, P1479, DOI 10.1523/JNEUROSCI.3711-06.2007 WENZEL G, 2006, PROGR ABSTR ARO M DE, P28 Wiech K, 2004, ANESTH ANALG, V98, P408, DOI 10.1213/01.ANE.0000096002.53818.BD Zheng YW, 2006, BRAIN RES, V1123, P201, DOI 10.1016/j.brainres.2006.09.045 NR 18 TC 15 Z9 17 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0194-5998 J9 OTOLARYNG HEAD NECK JI Otolaryngol. Head Neck Surg. PD APR PY 2008 VL 138 IS 4 BP 492 EP 496 DI 10.1016/j.otohns.2007.11.027 PG 5 WC Otorhinolaryngology; Surgery SC Otorhinolaryngology; Surgery GA 283MY UT WOS:000254641500016 PM 18359360 ER PT J AU Kleinjung, T Eichhammer, P Landgrebe, M Sand, P Hajak, G Steffens, T Strutz, J Langguth, B AF Kleinjung, Tobias Eichhammer, Peter Landgrebe, Michael Sand, Philipp Hajak, Goeran Steffens, Thomas Strutz, Juergen Langguth, Berthold TI Combined temporal and prefrontal transcranial magnetic stimulation for tinnitus treatment: A pilot study SO OTOLARYNGOLOGY-HEAD AND NECK SURGERY LA English DT Article ID AUDITORY-CORTEX; HUMAN BRAIN; RTMS AB OBJECTIVES: Low-frequency repetitive transcranial magnetic Stimulation (rTMS) of the temporal cortex has been proposed as a new treatment strategy for patients with chronic tinnitus. However, functional abnormalities in tinnitus patients also involve brain Structures used for attentional and emotional processing, Such as the dorsolateral prefrontal cortex. Therefore, we have developed a new rTMS treatment strategy for tinnitus patients that consists of a combination of high-frequency prefrontal and low-frequency temporal rTMS. STUDY DESIGN: A total of 32 patients received either low-frequency temporal rTMS or a combination of high-frequency prefrontal and low-frequency temporal rTMS. Treatment effects were assessed with a standardized tinnitus questionnaire (TQ). RESULTS: Directly after therapy there was an improvement of: the TQ-score for both groups, but no differences between groups. An evaluation after 3 months revealed a remarkable benefit from the use of combined prefrontal and temporal rTMS treatment. CONCLUSION: These results support recent data that suggest that auditory and nonauditory brain areas are involved in tinnitus pathophysiology. (C) 2008 American Academy of Otolaryngology-Head and Neck Surgery Foundation. All rights reserved. C1 [Kleinjung, Tobias; Steffens, Thomas; Strutz, Juergen] Univ Regensburg, Dept Otorhinolaryngol, D-93053 Regensburg, Germany. [Eichhammer, Peter; Landgrebe, Michael; Sand, Philipp; Hajak, Goeran; Langguth, Berthold] Univ Regensburg, Dept Psychiat & Psychotherapy, D-93053 Regensburg, Germany. RP Kleinjung, T (reprint author), Univ Regensburg, Dept Otorhinolaryngol, Franz Josef Str Allee 11, D-93053 Regensburg, Germany. EM tobias.kleinjung@klinik.uni-regensburg.de RI Sand, Philipp/C-1924-2009 OI Sand, Philipp/0000-0001-5806-5841 CR Alain C, 1998, BRAIN RES, V812, P23, DOI 10.1016/S0006-8993(98)00851-8 Arnold W, 1996, ORL J OTO-RHINO-LARY, V58, P195 Bao SW, 2001, NATURE, V412, P79, DOI 10.1038/35083586 Eichhammer P, 2003, BIOL PSYCHIAT, V54, P862, DOI 10.1016/S0006-3223(03)01896-6 GEORGE MS, 1995, NEUROREPORT, V6, P1853, DOI 10.1097/00001756-199510020-00008 GOEBEL G, 1994, HNO, V42, P166 Grunwald T, 2003, BIOL PSYCHIAT, V53, P511, DOI 10.1016/S0002-3223(03)01673-2 Hallett M, 2000, NATURE, V406, P147, DOI 10.1038/35018000 JASTREBOFF PJ, 1990, NEUROSCI RES, V8, P221, DOI 10.1016/0168-0102(90)90031-9 Kleinjung T, 2007, OTOLARYNG HEAD NECK, V137, P589, DOI 10.1016/j.otohns.2006.12.007 Kleinjung T, 2005, OTOLARYNG HEAD NECK, V132, P566, DOI 10.1016/j.otohns.2004.09.134 Marcondes Renata, 2006, Ear Nose Throat J, V85, P233 Moller AR, 2003, OTOLARYNG CLIN N AM, V36, P249, DOI 10.1016/S003-6665(02)00170-6 Muhlau M, 2006, CEREB CORTEX, V16, P1283, DOI 10.1093/cercor/bhj070 Muhlnickel W, 1998, P NATL ACAD SCI USA, V95, P10340, DOI 10.1073/pnas.95.17.10340 Norena A, 1999, CLIN NEUROPHYSIOL, V110, P666, DOI 10.1016/S1388-2457(98)00034-0 Paus T, 2001, EUR J NEUROSCI, V14, P1405, DOI 10.1046/j.0953-816x.2001.01757.x Plewnia C, 2007, J NEUROL NEUROSUR PS, V78, P152, DOI 10.1136/jnnp.2006.095612 Rossi S, 2007, J NEUROL NEUROSUR PS, V78, P857, DOI 10.1136/jnnp.2006.105007 Smith JA, 2007, LARYNGOSCOPE, V117, P529, DOI 10.1097/MLG.0b013e31802f4154 Strafella AP, 2001, J NEUROSCI, V21 NR 21 TC 63 Z9 65 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0194-5998 J9 OTOLARYNG HEAD NECK JI Otolaryngol. Head Neck Surg. PD APR PY 2008 VL 138 IS 4 BP 497 EP 501 DI 10.1016/j.otohns.2007.12.022 PG 5 WC Otorhinolaryngology; Surgery SC Otorhinolaryngology; Surgery GA 283MY UT WOS:000254641500017 PM 18359361 ER PT J AU Granjeiro, RC Kehrle, HM Bezerra, RL Almeida, VF Sampaio, ALL Oliveira, CA AF Granjeiro, Ronaldo C. Kehrle, Helga M. Bezerra, Roberta L. Almeida, Vanessa F. Sampaio, Andre L. L. Oliveira, Carlos A. TI Transient and distortion product evoked oto-acoustic emission in normal hearing patients with and without tinnitus SO OTOLARYNGOLOGY-HEAD AND NECK SURGERY LA English DT Article ID IMPAIRED SUBJECTS; PERCEPTION; MECHANISMS; EARS AB OBJECTIVE: To test the hypothesis that tinnitus begins with outer hair cell dysfunction by recording transient (TEOAE) and distortion product evoked (DPOAE) oto-acoustic emissions in patients with normal hearing with (study group, SG) and without tinnitus (control group, CG). STUDY DESIGN: Case control study. SUBJECTS AND METHODS: SG had 32 patients with pure tone thresholds below 25 dB in the 500 to 8000 Hz interval. CG had 37 age- and gender-matched patients with similar thresholds. All patients had normal tympanograms and stapedial reflexes. TEOAE were recorded with wide band click in continuous mode at 80-dB peak SPL. DPOAE were recorded with f1/f2 = 1.22 and intensities of 65 dB (f1) and 55 dB (f2) SPL. RESULTS: DPOAE were abnormal in 68.4% of SG and in 50% of CG (P = 0.036). TEOAE were abnormal in 70.2% of SG and in 16.10% of CG (P = 0.0001). CONCLUSION: SG had significantly higher prevalence of abnormal TEOAE and DPOAE than CG. (C) 2008 American Academy of Otolaryngology-Head and Neck Surgery Foundation. All rights reserved. C1 [Bezerra, Roberta L.; Sampaio, Andre L. L.; Oliveira, Carlos A.] Univ Brasilia, Sch Med, Dept Otolaryngol Head & Neck Surg, BR-70910900 Brasilia, DF, Brazil. RP Granjeiro, RC (reprint author), SQSW, 305 Bloco C,Apartment 302, BR-70673423 Brasilia, DF, Brazil. EM ronaldogranjeiro@terra.com.br CR AXELSSON A, 1989, British Journal of Audiology, V23, P53, DOI 10.3109/03005368909077819 BONFILS P, 1992, ARCH OTOLARYNGOL, V118, P1069 GORGA MP, 1993, J ACOUST SOC AM, V94, P2639, DOI 10.1121/1.407348 GORGA MP, 1993, J ACOUST SOC AM, V93, P2050, DOI 10.1121/1.406691 Gorga MP, 1997, EAR HEARING, V18, P440, DOI 10.1097/00003446-199712000-00003 Harrison WA, 1999, EAR HEARING, V20, P75, DOI 10.1097/00003446-199902000-00007 JASTREBOFF PJ, 1990, NEUROSCI RES, V8, P221, DOI 10.1016/0168-0102(90)90031-9 Kaltenbach J A, 2000, J Am Acad Audiol, V11, P125 Kaltenbach JA, 2000, HEARING RES, V140, P165, DOI 10.1016/S0378-5955(99)00197-5 LONSBURYMARTIN BL, 1991, J SPEECH HEAR RES, V34, P964 Mirz F, 1999, HEARING RES, V134, P133, DOI 10.1016/S0378-5955(99)00075-1 MOLLER AR, 1984, ANN OTO RHINOL LARYN, V93, P39 Nicolas-Puel Cécile, 2002, Int Tinnitus J, V8, P37 Norena A, 2002, AUDIOL NEURO-OTOL, V7, P358, DOI 10.1159/000066156 Ochi K, 2003, LARYNGOSCOPE, V113, P427, DOI 10.1097/00005537-200303000-00007 OLIVEIRA CA, 1995, INTER TIN J, V1, P1 PROBST R, 1990, AM J OTOLARYNG, V11, P236, DOI 10.1016/0196-0709(90)90083-8 PROBST R, 1991, J ACOUST SOC AM, V11, P236 ROBINETTE MS, 1997, OTOACOUSTIC EMISSION, P63 Simpson JJ, 2000, HEARING RES, V145, P1, DOI 10.1016/S0378-5955(00)00093-9 NR 20 TC 14 Z9 14 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0194-5998 J9 OTOLARYNG HEAD NECK JI Otolaryngol. Head Neck Surg. PD APR PY 2008 VL 138 IS 4 BP 502 EP 506 DI 10.1016/j.otohns.2007.11.012 PG 5 WC Otorhinolaryngology; Surgery SC Otorhinolaryngology; Surgery GA 283MY UT WOS:000254641500018 PM 18359362 ER PT J AU Parrilla, C Galli, J Fetoni, AR Rigante, M Paludetti, G AF Parrilla, Claudio Galli, Jacopo Fetoni, Anna Rita Rigante, Mario Paludetti, Gaetano TI Erbium: Yttrium-aluminum-garnet laser stapedotomy - A safe technique SO OTOLARYNGOLOGY-HEAD AND NECK SURGERY LA English DT Article ID CO2-LASER STAPEDOTOMY; OTOSCLEROSIS SURGERY; BONE ABLATION; ARGON-LASER; ER-YAG AB OBJECTIVE: To standardize the technical parameters of the erbium: yttrium-aluminum-garnet (Er:YAG) laser stapedotomy. STUDY DESIGN: Retrospective study of all patients with otosclerosis who underwent stapedotomy from January 2002 to January 2006. SUBJECTS AND METHODS: The charts of 152 consecutive patients who underwent stapedotomy were reviewed. The patients were stratified into two groups, according to the instrument used. Stapedotomies were performed in group A, with the OPMI((R))TwinEr: YAG laser; and in group B with manual microperforators. RESULTS: No statistically significant differences were found over all measured frequencies, between pre- and postoperative bone conduction thresholds, in each group. At the last postoperative follow-up, vertigo and nystagmus were not detected; two patients in group A and one patient in group B showed persistent tinnitus. CONCLUSION: Er:YAG laser stapedotomy is a safe and effective procedure, with no damage of the inner ear when strict adherence to the safety parameters is observed. The Er:YAG laser is definitively suitable for stapes surgery, and represents a useful and safe tool in the armamentarium of otological inicrosurgery. (C) 2008 American Academy of Otolaryngology-Head and Neck Surgery Foundation. All rights reserved. C1 [Parrilla, Claudio; Galli, Jacopo; Fetoni, Anna Rita; Rigante, Mario; Paludetti, Gaetano] Univ Cattolica Sacro Cuore, Inst Otolaryngol, I-00168 Rome, Italy. RP Parrilla, C (reprint author), Univ Cattolica Sacro Cuore, Inst Otolaryngol, Largo Gemelli 8, I-00168 Rome, Italy. EM claudioparrilla@yahoo.com CR American Academy of Otolaryngology-Head and Neck Surgery Foundation Inc, 1995, OTOLARYNGOL HEAD NEC, V113, P186, DOI DOI 10.1016/S0194-5998(95)70103-6 Arnoldner C, 2006, OTOL NEUROTOL, V27, P458, DOI 10.1097/00129492-200606000-00005 Buchman CA, 2000, AM J OTOLARYNG, V21, P227, DOI 10.1053/ajot.2000.8380 DIBARTOLOMEO JR, 1980, LARYNGOSCOPE, V90, P1786, DOI 10.1288/00005537-198011000-00005 Galli J, 2005, OTOLARYNG HEAD NECK, V133, P923, DOI 10.1016/j.otohns.2005.04.007 HALLSLER R, 1999, ACTA OTO-LARYNGOL, V119, P207 HIBST R, 1992, LASER SURG MED, V12, P125, DOI 10.1002/lsm.1900120203 Huber A, 2001, OTOL NEUROTOL, V22, P311, DOI 10.1097/00129492-200105000-00007 JOVANOVIC S, 1995, EUR ARCH OTO-RHINO-L, V252, P422 Jovanovic S, 2004, OTOLARYNG HEAD NECK, V131, P750, DOI 10.1016/j.otohns.2004.05.008 Keck T, 2005, LARYNGOSCOPE, V115, P1627, DOI 10.1097/01.mlg.0000173164.64044.74 Keck T, 2002, OTOL NEUROTOL, V23, P21, DOI 10.1097/00129492-200201000-00006 Lesinski S G, 1989, Laryngoscope, V99, P9 Lesinski SG, 2003, OTOL NEUROTOL, V11, P347 LI ZZ, 1992, LASER SURG MED, V12, P79, DOI 10.1002/lsm.1900120112 PALVA T, 1987, ACTA OTO-LARYNGOL, V104, P153, DOI 10.3109/00016488709109061 PERKINS RC, 1980, LARYNGOSCOPE, V90, P228 Pratistio H, 1996, LASER SURG MED, V18, P100, DOI 10.1002/(SICI)1096-9101(1996)18:1<100::AID-LSM14>3.0.CO;2-D Vernick DM, 1996, AM J OTOL, V17, P221 NR 19 TC 12 Z9 13 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0194-5998 J9 OTOLARYNG HEAD NECK JI Otolaryngol. Head Neck Surg. PD APR PY 2008 VL 138 IS 4 BP 507 EP 512 DI 10.1016/j.otohns.2007.12.033 PG 6 WC Otorhinolaryngology; Surgery SC Otorhinolaryngology; Surgery GA 283MY UT WOS:000254641500019 PM 18359363 ER PT J AU Castillo, MP Samy, RN Isaacson, B Roland, PS AF Castillo, Michael P. Samy, Ravi N. Isaacson, Brandon Roland, Peter S. TI Petrous apex cholesterol granuloma aeration: Does it matter SO OTOLARYNGOLOGY-HEAD AND NECK SURGERY LA English DT Article ID TERM FOLLOW-UP; MANAGEMENT; DIAGNOSIS; LESIONS; CYSTS AB OBJECTIVE: To determine whether aeration of surgically treated petrous apex cholesterol granulomas (PA CG) has any correlation with resolution of symptoms. STUDY DESIGN: Retrospective chart review. SUBJECTS: Twenty-six patients with a petrous apex cholesterol granuloma during a 16-year period were reviewed. RESULTS: Seventeen of 26 (65%) patients underwent surgical intervention. Preoperative symptoms included headache, facial weakness/twitching or numbness, vertigo, hearing loss, vision changes. and tinnitus. Postoperative symptoms resolved in 9 of the 16 patients (56%). Three patients had a postoperative headache. Facial nerve dysfunction persisted or recurred in four patients. One patient was lost to follow-up. Thirteen patients had postoperative imaging. All 13 (100%) patients demonstrated stable or increased size of PA CG with no evidence of aeration. Revision surgery was per-formed in four patients (25%) for facial nerve symptoms or persistent headaches. CONCLUSION: The extent of PA CG aeration on postoperative imaging had no correlation to symptom resolution or cyst enlargement. Revision surgery should not depend on imaging alone but primarily on patient symptoms and physical exam. (C) 2008 American Academy of Otolaryngology-Head and Neck Surgery Foundation. All rigdhts reserved. RP Isaacson, B (reprint author), 5323 Harry Hines Blvd, Dallas, TX 75390 USA. EM brandon.isaacson@utsouthwestern.edu RI Isaacson, Brandon/A-6358-2013 CR ALTSCHULER EM, 1990, NEUROSURGERY, V26, P606 Brackmann DE, 2002, OTOL NEUROTOL, V23, P529, DOI 10.1097/00129492-200207000-00023 BRACKMANN DE, 1979, ACOUSTIC TUMORS MANA, P15 Cristante L, 2000, SURG NEUROL, V53, P64, DOI 10.1016/S0090-3019(99)00163-9 Eisenberg MB, 1997, J NEUROSURG, V86, P822, DOI 10.3171/jns.1997.86.5.0822 FONG BP, 1995, ARCH OTOLARYNGOL, V121, P426 FRIEDMANN I, 1959, Ann Otol Rhinol Laryngol, V68, P57 GHERINI SG, 1985, LARYNGOSCOPE, V95, P659 GIDDINGS NA, 1991, OTOLARYNG HEAD NECK, V104, P29 GOLDOFSKY E, 1991, ANN OTO RHINOL LARYN, V100, P181 Griffith AJ, 1996, OTOLARYNG HEAD NECK, V114, P91 HIRAIDE F, 1982, J LARYNGOL OTOL, V96, P491, DOI 10.1017/S0022215100092768 HOUSE WF, 1992, NEUROLOGICAL SURG EA, P66 Isaacson B, 2007, OTOLARYNG CLIN N AM, V40, P479, DOI 10.1016/j.otc.2007.03.003 Jackler RK, 2003, OTOL NEUROTOL, V24, P96, DOI 10.1097/00129492-200301000-00020 Miura M, 2002, ANN OTO RHINOL LARYN, V111, P609 Mosnier I, 2002, OTOL NEUROTOL, V23, P522, DOI 10.1097/00129492-200207000-00022 Muckle RP, 1998, AM J OTOL, V19, P219 THEDINGER BA, 1989, LARYNGOSCOPE, V99, P896 TOS M, 1991, TRANSLABYRINTH ME AC, P6 NR 20 TC 9 Z9 9 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0194-5998 J9 OTOLARYNG HEAD NECK JI Otolaryngol. Head Neck Surg. PD APR PY 2008 VL 138 IS 4 BP 518 EP 522 DI 10.1016/j.otohns.2007.12.012 PG 5 WC Otorhinolaryngology; Surgery SC Otorhinolaryngology; Surgery GA 283MY UT WOS:000254641500021 PM 18359365 ER PT J AU Newman, CW Sandridge, SA Bolek, L AF Newman, Craig W. Sandridge, Sharon A. Bolek, Lauren TI Development and psychometric adequacy of the screening version of the Tinnitus Handicap Inventory SO OTOLOGY & NEUROTOLOGY LA English DT Article DE handicap measure; screening; THI; tinnitus ID RETRAINING THERAPY; QUESTIONNAIRE; POPULATION; SEVERITY; OUTCOMES; HEARING AB Objective: To develop a screening version of the Tinnitus Handicap Inventory (THI-S) and establish its psychometric characteristics. Design: Prospective clinical study to analyze 1) the level of predictability between THI and THI-S; 2) test-retest reliability of the THI-S; 3) 95% confidence intervals (critical difference scores) for the THI-S; and 4) a THI-S cutoff score used for referral purposes. Setting: Head and Neck Institute at the Cleveland Clinic, a tertiary care medical center. Patients: Thirty-three patients reporting tinnitus as their primary complaint. Interventions: There was, on average, a 16-day interval between test-retest administrations of the THI-S. Main Outcome Measure: Comparability of scores between the THI and the THI-S and test-retest reliability of the THI-S was assessed using Pearson product-moment correlations. The level of agreement between the 2 administrations of the THI-S was evaluated using Bland-Altman repeatability plots. Results: Comparability between the THI and THI-S was high (r = 0.90). Test-retest reliability of the THI-S was adequate (r = 0.81), as well as the level of agreement between administrations as demonstrated by the Bland-Altman plot. Based on 95% confidence intervals, pretreatment and posttreatment scores would have to differ by more than 10 points for intervention efforts to be considered significant. A 6-point cutoff score was analyzed as an appropriate fence for referral. Conclusion: The THI-S is a psychometrically robust screening measure of activity limitation and participation restriction. C1 [Newman, Craig W.; Sandridge, Sharon A.] Cleveland Clin, Head & Neck Inst, Sect Audiol, Cleveland, OH USA. [Bolek, Lauren] Vanderbilt Univ, Dept Hearing & Speech Sci, Vanderbilt Bill Wilkerson Ctr, Nashville, TN USA. RP Newman, CW (reprint author), Cleveland Clin, Head & Neck Inst A71, 9500 Euclid Ave, Cleveland, OH 44106 USA. EM newmanc@ccf.org CR Altman DG, 1983, STATISTICIAN, V32, P301 Baguley DM, 2000, J LARYNGOL OTOL, V114, P840 Berry JA, 2002, ARCH OTOLARYNGOL, V128, P1153 BLAND JM, 1985, LANCET, P307 *BRIT STAND I, 1981, 5497 BS BRIT STAND I DEMOREST ME, 1984, J SPEECH HEAR DISORD, V49, P226 Dobie R, 2004, TINNITUS THEORY MANA, P1 Hebert S, 2007, EAR HEARING, V28, P649 Henry JA, 2006, J AM ACAD AUDIOL, V17, P104, DOI 10.3766/jaaa.17.2.4 Jacobson GP, 1998, AM J OTOL, V19, P804 JAKES SC, 1985, AUDIOLOGY, V24, P195 Kinney SE, 1997, AM J OTOL, V18, P67 McCombe A, 2001, CLIN OTOLARYNGOL, V26, P388, DOI 10.1046/j.1365-2273.2001.00490.x MEIKLE MB, 1984, OTOLARYNG HEAD NECK, V92, P689 Newman C. W., 2004, TINNITUS THEORY MANA, P237 Newman CW, 1996, ARCH OTOLARYNGOL, V122, P143 Newman C W, 1998, J Am Acad Audiol, V9, P153 NEWMAN CW, 1991, EAR HEARING, V12, P355, DOI 10.1097/00003446-199110000-00009 NEWMAN CW, 2006, TINITUS TREATMENT CL, P187 Nunnally JC, 1978, PSYCHOMETRIC THEORY Sanchez L, 1997, EAR HEARING, V18, P210, DOI 10.1097/00003446-199706000-00004 Surr R K, 1999, J Am Acad Audiol, V10, P489 TYLER RS, 1983, J SPEECH HEAR DISORD, V48, P150 Ventry I M, 1983, ASHA, V25, P37 World Health Organization, 2004, INT STAT CLASS DIS H NR 25 TC 10 Z9 12 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1531-7129 J9 OTOL NEUROTOL JI Otol. Neurotol. PD APR PY 2008 VL 29 IS 3 BP 276 EP 281 PG 6 WC Clinical Neurology; Otorhinolaryngology SC Neurosciences & Neurology; Otorhinolaryngology GA 288IW UT WOS:000254980800002 PM 18277308 ER PT J AU Arganbright, J Friedland, DR AF Arganbright, Jill Friedland, David R. TI Pulsatile tinnitus SO OTOLOGY & NEUROTOLOGY LA English DT Editorial Material C1 [Arganbright, Jill; Friedland, David R.] Med Coll Wisconsin, Dept Otolaryngol & Commun Sci, Milwaukee, WI 53226 USA. RP Friedland, DR (reprint author), Med Coll Wisconsin, Dept Otolaryngol & Commun Sci, 9200 W Wisconsin Ave, Milwaukee, WI 53226 USA. EM dfriedla@mcw.edu CR Branstetter BF, 2006, EUR RADIOL, V16, P2792, DOI 10.1007/s00330-006-0306-2 JUN BC, 2005, J LARYNGOL OTOL, V199, P693 Liyanage SH, 2006, J LARYNGOL OTOL, V120, P93, DOI 10.1017/S0022215105001714 NR 3 TC 0 Z9 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1531-7129 J9 OTOL NEUROTOL JI Otol. Neurotol. PD APR PY 2008 VL 29 IS 3 BP 416 EP 416 PG 1 WC Clinical Neurology; Otorhinolaryngology SC Neurosciences & Neurology; Otorhinolaryngology GA 288IW UT WOS:000254980800027 PM 17728689 ER PT J AU Buchmann, J Arens, U Harke, G Smolenski, U AF Buchmann, J. Arens, U. Harke, G. Smolenski, U. TI Manual Medicine in the differential diagnosis of dizziness and tinnitus SO PHYSIKALISCHE MEDIZIN REHABILITATIONSMEDIZIN KURORTMEDIZIN LA German DT Article DE dizziness; tinnitus; functional disturbances of the locomotor system; Manual Medicine; osteopathy ID PHOBIC POSTURAL VERTIGO; COGNITIVE-BEHAVIORAL THERAPY; MAGNETIC STIMULATION RTMS; BALANCE PERFORMANCE; POSITIONAL VERTIGO; INJURY AB Dizziness and tinnitus are extraordinary frequent symptoms lamented by many patients. No correlates are found at a large portion of these complaints in machine-aided examinations. The Manual Medicine can make a contribution to the differential diagnosis process of dizziness and tinnitus. In the following contribution differential diagnosis and therapy of this complex are represented as well as manual medically based syndromes "dizziness" and "tinnitus" are introduced and discussed. RP Buchmann, J (reprint author), Univ Rostock, Zentrum Nervenheilkunde, Arztegesellschaft Manuelle Med Berliner Seminar, Klin Neurol Psychiat Psychotherapie Kindes & Juge, Gehlsheimer Str 20, D-18147 Rostock, Germany. EM johannes.buchmann@med.uni-rostock.de CR BOENNINGHAUS HC, 2007, HALS NASEN OHRENHEIL Brandt T, 1997, NERVENARZT, V68, P848, DOI 10.1007/s001150050205 Brandt T, 1996, NEUROLOGY, V46, P1515 BUCKUP K, 2005, KLINISCHE TESTS KNOC Dieterich M, 2001, ADV NEUROL, V87, P225 Dieterich M, 2004, NERVENARZT, V75, P281, DOI 10.1007/s00115-003-1678-z Guitton MJ, 2004, ACTA OTO-LARYNGOL, V124, P411, DOI 10.1080/00016480310000665 GUTMANN G, 1984, HALSWIRBELSAULE ALLG Hansson EE, 2005, SCAND J PRIM HEALTH, V23, P215, DOI 10.1080/02813430500287299 Henry JA, 2005, J SPEECH LANG HEAR R, V48, P1204, DOI 10.1044/1092-4388(2005/084) HINKELTHEIN E, 2006, DIAGNOSE THERAPIEKON Holmberg J, 2006, J NEUROL, V253, P500, DOI 10.1007/s00415-005-0050-6 Johansson M, 2001, OTOLARYNG HEAD NECK, V125, P151, DOI 10.1067/mhn.2001.118127 KEIDEL M, 1998, THERAPIE VERLAUF NEU, P69 KEIDEL M, 1995, NEUROORTHOPADIE, V6 Kleinjung T, 2006, HNO, V54, P439, DOI 10.1007/500106-005-1329-8 Londero A, 2006, NEUROPHYSIOL CLIN, V36, P145, DOI 10.1016/j.neucli.2006.08.001 LOSERTBRUCKNER B, 1999, GLEICHGEWICHTSSTORUN, V37, P101 Marcondes Renata, 2006, Ear Nose Throat J, V85, P233 Marcondes R, 2006, ENT-EAR NOSE THROAT, V85, P236 Moller AR, 2003, OTOLARYNG CLIN N AM, V36, P249, DOI 10.1016/S003-6665(02)00170-6 Motin M, 2005, BRAIN INJURY, V19, P693, DOI 10.1080/02699050400013600 MUMENTHALER M, 2005, NEUROLOGISCHE DIFFER Neuhuber W, 2007, MANMED, V45, P227, DOI 10.1007/s00337-007-0532-y NEUHUBER WL, 2005, OBERE HALSWIRBELSAUK, P55 PAULUS W, 1998, SCHMERZSYNDROME KOPF Querner V, 2000, NEUROSCI LETT, V285, P21, DOI 10.1016/S0304-3940(00)01008-9 Ramos RT, 2006, J PSYCHOPHARMACOL, V20, P708, DOI 10.1177/0269881106060660 Reid SA, 2005, MANUAL THER, V10, P4, DOI 10.1016/j.math.2004.03.006 Sachse J, 2000, WIRBELSAULE MANUELLE Schilter B, 2000, HNO, V48, P589, DOI 10.1007/s001060050621 SHUTTY MS, 1991, ARCH PHYS MED REHAB, V72, P473 Staab JP, 2006, CURR OPIN NEUROL, V19, P41, DOI 10.1097/01.wco.0000198102.95294.1f Strupp M, 2003, NERVENARZT, V74, P911, DOI 10.1007/s00115-003-1567-5 Strupp M, 2000, NERVENARZT, V71, P138, DOI 10.1007/s001150050021 Sturm A, 2003, DIFFERENZIALDIAGNOSE Treleaven J, 2003, J REHABIL MED, V35, P36, DOI 10.1080/16501970306109 Xenellis J, 2005, OTOL NEUROTOL, V26, P1149, DOI 10.1097/01.mao.0000194888.36400.d5 NR 38 TC 1 Z9 1 PU GEORG THIEME VERLAG KG PI STUTTGART PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY SN 0940-6689 J9 PHYS MED REHAB KUROR JI Physik. Med. Rehabilitationsmed. Kurort. PD APR PY 2008 VL 18 IS 2 BP 87 EP 95 DI 10.1055/s-2008-1042432 PG 9 WC Rehabilitation; Sport Sciences SC Rehabilitation; Sport Sciences GA 300PU UT WOS:000255838500005 ER PT J AU Cherian, N Baron, E AF Cherian, Neil Baron, Eric TI Novel role of greater occipital nerve trigger point injections in a sub-set of tinnitus patients SO NEUROLOGY LA English DT Meeting Abstract CT 6th Annual Meeting of the American-Academy-of-Neurology CY APR 12-19, 2008 CL Chicago, IL SP Amer Acad Neurol NR 0 TC 0 Z9 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0028-3878 J9 NEUROLOGY JI Neurology PD MAR 11 PY 2008 VL 70 IS 11 SU 1 BP A262 EP A262 PG 1 WC Clinical Neurology SC Neurosciences & Neurology GA 319XB UT WOS:000257197201397 ER PT J AU Piera, A Lainez, MJA De Paula, C Avila, C Campos, S AF Piera, Anna Lainez, Miguel J. A. De Paula, Carlos Avila, Cesar Campos, Salvador TI Chronic tinnitus: A neurological problem SO NEUROLOGY LA English DT Meeting Abstract CT 6th Annual Meeting of the American-Academy-of-Neurology CY APR 12-19, 2008 CL Chicago, IL SP Amer Acad Neurol NR 0 TC 0 Z9 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0028-3878 J9 NEUROLOGY JI Neurology PD MAR 11 PY 2008 VL 70 IS 11 SU 1 BP A263 EP A263 PG 1 WC Clinical Neurology SC Neurosciences & Neurology GA 319XB UT WOS:000257197201399 ER PT J AU Mishra, S Walmsley, SL Loutfy, MR Kaul, R Logue, KJ Gold, WL AF Mishra, Sharmistha Walmsley, Sharon Lynn Loutfy, Mona Rafik Kaul, Rupert Logue, Kenneth John Gold, Wayne Lawrence TI Otosyphilis in HIV-coinfected individuals: A case series from Toronto, Canada SO AIDS PATIENT CARE AND STDS LA English DT Article; Proceedings Paper CT 44th Annual Meeting of the Infectious-Diseases-Society-of-America CY OCT 12-15, 2006 CL Toronto, CANADA SP Infect Dis Soc Amer ID HUMAN-IMMUNODEFICIENCY-VIRUS; HEARING-LOSS; SECONDARY SYPHILIS; SAN-FRANCISCO; NEUROSYPHILIS; THERAPY; INFECTION; DEAFNESS; PATIENT; UPDATE AB We sought to identify and review the clinical features and treatment outcomes of eight recent cases of otosyphilis in HIV-positive patients seen in Toronto. All patients reported tinnitus, and seven (87.5%) reported subjective hearing loss. Not taking auditory findings into consideration, four patients would be classified as having secondary syphilis, three patients as having early latent syphilis, and one patient as having latent syphilis of unknown duration. The median CD4 cell count was 370 x 10(6)/L. All patients were treated with intravenous aqueous penicillin G with regimens recommended for the treatment of neurosyphilis; four patients received adjunctive steroids. All eight patients experienced improvement in tinnitus and four of the seven (57.1%) patients with symptomatic hearing loss also experienced improvement. Otosyphilis can occur in HIV-positive individuals despite high CD4 cell counts, and is potentially reversible. Increased awareness of uncommon manifestations of syphilis in high-risk individuals is warranted to prompt appropriate investigation and treatment. C1 [Mishra, Sharmistha; Walmsley, Sharon Lynn; Kaul, Rupert; Logue, Kenneth John; Gold, Wayne Lawrence] Univ Hlth Network, Div Infect Dis, Toronto, ON, Canada. [Mishra, Sharmistha; Walmsley, Sharon Lynn; Loutfy, Mona Rafik; Kaul, Rupert; Logue, Kenneth John; Gold, Wayne Lawrence] Univ Toronto, Dept Med, Toronto, ON, Canada. [Loutfy, Mona Rafik] Maple Leaf Clin, Toronto, ON, Canada. RP Mishra, S (reprint author), 200 Elzabeth St 13EN-1319, Toronto, ON M5G 2C4, Canada. 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Sugiura, Makoto Teranishi, Masaaki Katayama, Naomi Nakashima, Tsutomu TI Otoacoustic emissions, ear fullness and tinnitus in the recovery course of sudden deafness SO AURIS NASUS LARYNX LA English DT Article; Proceedings Paper CT 20th Biennial Symposium of the International-Evoked-Response-Audiometry-Study-Group CY JUN 10-14, 2007 CL Bled, SLOVENIA SP Int Evoked Response Audiometry Study Grp DE sudden sensorineural hearing loss; follow-up; tinnitus; ear fullness; otoacoustic emissions; recovery course ID SENSORINEURAL HEARING-LOSS AB Objective: This study aimed to investigate how the symptoms of ear fullness, tinnitus and otoacoustic emissions (OAE) change in relation to the recovery course of pure tone audiometry thresholds (PTA) in sudden deafness (SD). Methods: This study analyzed follow-up data on ear fullness, tinnitus and otoacoustic emissions of eight SD patients with good hearing improvement (Group A) and eight SD patients with poor hearing improvement (Group B) in an attempt to elucidate the behavior of these symptoms in their recovery course. This study was done until there was no change in the PTA for more than I week and hearing recovery was no longer expected. Results: All patients from both groups had ear fullness and tinnitus in association with the onset of SD. However, these symptoms improved only in Group A. showing a significant relationship between PTA recovery and the improvement of ear fullness annoyance (P < 0.05), presence of tinnitus (P < 0.01), improvement in tinnitus loudness (P < 0.01) and in tinnitus annoyance (P < 0.01). No patients (Group A or B) had OAE responses at their first examination. In Group A, OAE responses appeared simultaneously with improvement of hearing levels in five patients (63%) and it appeared later than hearing levels improvement in the other three patients (37%) from Group A. No patient from Group B showed OAE response on follow-up. Conclusion: SD patients with good hearing improvement (Group A) tended to have OAE responses and the sensations of the ear fullness and tinnitus improved almost simultaneously with hearing level improvement. Their PTA improvement occurred primarily in the low to mid frequencies, with high frequencies showing less recovery. When hearing recovery was not full, OAEs did not reappear for these frequencies. Patients with poor hearing improvement tended to have absent OAEs and persistent ear fullness and tinnitus. (c) 2007 Elsevier Ireland Ltd. All rights reserved. C1 [Ishida, Ieda M.; Sugiura, Makoto; Teranishi, Masaaki; Katayama, Naomi; Nakashima, Tsutomu] Nagoya Univ, Grad Sch Med, Dept Otorhinolaryngol, Showa Ku, Nagoya, Aichi 4668550, Japan. [Katayama, Naomi] Nagoya Womens Univ, Mizuho Ku, Nagoya, Aichi, Japan. RP Ishida, IM (reprint author), Nagoya Univ, Grad Sch Med, Dept Otorhinolaryngol, Showa Ku, 65 Tsurumai Cho, Nagoya, Aichi 4668550, Japan. EM iishida@med.nagoya-u.acjp RI Nakashima, Tsutomu/B-8259-2012; Teranishi, Masaaki/I-1956-2012 OI Nakashima, Tsutomu/0000-0003-3930-9120; CR Ben-David J, 2001, Int Tinnitus J, V7, P62 Gorga MP, 1997, EAR HEARING, V18, P440, DOI 10.1097/00003446-199712000-00003 Kemp DT, 2002, BRIT MED BULL, V63, P223, DOI 10.1093/bmb/63.1.223 Lalaki P, 2001, SCAND AUDIOL, V30, P141, DOI 10.1080/010503901300007344 Mamak Aydin, 2005, Ear Nose Throat J, V84, P641 NAKASHIMA T, 1993, LARYNGOSCOPE, V103, P1145 Sakata T, 2006, ACTA OTO-LARYNGOL, V126, P828, DOI 10.1080/00016480500527268 Seixas NS, 2004, OCCUP ENVIRON MED, V61, P899, DOI 10.1136/oem.2003.009209 Stavroulaki P, 2002, ARCH OTOLARYNGOL, V128, P150 Sugiura M, 2006, LARYNGOSCOPE, V116, P1451, DOI 10.1097/01.mlg.0000228005.78187.23 Zhang Q, 1999, Lin Chuang Er Bi Yan Hou Ke Za Zhi, V13, P443 NR 11 TC 2 Z9 2 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0385-8146 J9 AURIS NASUS LARYNX JI Auris Nasus Larynx PD MAR PY 2008 VL 35 IS 1 BP 41 EP 46 DI 10.1016/j.anl.2007.04.003 PG 6 WC Otorhinolaryngology SC Otorhinolaryngology GA 263VM UT WOS:000253244600006 PM 17904320 ER PT J AU LlaneS, EGDV Stibal, A Muhlethaler, K Vajtai, I Hausler, R Caversaccio, M AF LlaneS, Erasmo Gonzalo D. V. Stibal, Alexander Muehlethaler, Konrad Vajtai, Istvan Haeusler, Rudolf Caversaccio, Marco TI Echinococcosis presenting as an otogenic brain abscess: An unusual lesion of the middle ear cleft and temporal lobe SO AURIS NASUS LARYNX LA English DT Article DE echinococcosis; otogenic brain abscess; middle ear cleft ID BONE AB This paper presents a case of a 28-year-old male with a seizure episode and a 4-year history of intermittent tinnitus on the left ear. On computed tomography and magnetic resonance imaging, a density with rim enhancement was found at the temporal lobe, associated with mastoid tegmen destruction and middle ear mass, indicating cholesteatoma with complicating brain abscess. Evacuation of the brain abscess was performed with a combined otolaryngologic and neurosurgical procedures (canal wall-down mastoidectomy and temporal craniotomy). The pathology turned out to be infestation with Echinococcus granulosus. (c) 2007 Elsevier Ireland Ltd. All rights reserved. C1 [LlaneS, Erasmo Gonzalo D. V.; Haeusler, Rudolf; Caversaccio, Marco] Univ Bern, Inselspital, Dept Otorhinolaryngol Head & Neck Surg, CH-3010 Bern, Switzerland. [Stibal, Alexander] Univ Bern, Inselspital, Dept Neurosurg, CH-3010 Bern, Switzerland. [Muehlethaler, Konrad] Univ Bern, Inselspital, Dept Infect Dis, CH-3010 Bern, Switzerland. [Muehlethaler, Konrad] Univ Bern, Inst Infect Dis, CH-3010 Bern, Switzerland. Univ Bern, Inst Pathol, Bern, Switzerland. RP Caversaccio, M (reprint author), Univ Bern, Inselspital, Dept Otorhinolaryngol Head & Neck Surg, CH-3010 Bern, Switzerland. EM marco.caversaccio@insel.ch RI Kummer, Juerg/B-3322-2011 CR Altinors N, 2000, J NEUROSURG, V93, P1, DOI 10.3171/jns.2000.93.1.0001 Bükte Yaşar, 2004, Swiss Med Wkly, V134, P459 Eckert J, 2004, CLIN MICROBIOL REV, V17, P107, DOI 10.1128/CMR.17.1.107-135.2004 Ennouri S, 2000, AM J ROENTGENOL, V175, P923 McManus DP, 2003, LANCET, V362, P1295, DOI 10.1016/S0140-6736(03)14573-4 MULLER J, 1992, HNO, V40, P356 Penido ND, 2005, OTOLARYNG HEAD NECK, V132, P37, DOI 10.1016/j.otohns.2004.08.007 Sennaroglu L, 2000, OTOLARYNG HEAD NECK, V123, P751, DOI 10.1067/mhn.2000.107887 NR 8 TC 2 Z9 2 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0385-8146 J9 AURIS NASUS LARYNX JI Auris Nasus Larynx PD MAR PY 2008 VL 35 IS 1 BP 115 EP 120 DI 10.1016/j.anl.2007.07.007 PG 6 WC Otorhinolaryngology SC Otorhinolaryngology GA 263VM UT WOS:000253244600017 PM 17826931 ER PT J AU Jia, H Marzin, A DubreUil, C Tringali, S AF Jia, Huan Marzin, Alexandre DubreUil, Christian Tringali, Stephane TI Intralabyrinthine schwannomas: Symptoms and managements SO AURIS NASUS LARYNX LA English DT Article DE intralabyrinthine; schwannomas; management ID INTRACOCHLEAR SCHWANNOMA; COCHLEAR IMPLANTATION; ACOUSTIC NEURINOMAS; VESTIBULAR NERVE; DIAGNOSIS; NEUROMAS; TUMORS; MRI AB Objective: To describe the characteristic presentations, radiologic findings and managements of the intralabyrinthine schwannomas. Method: Retrospective review of patient records, their managements, and review of the literature. Result: Four patients with a variety of otologic symptoms including hearing loss, vertigo, and tinnitus were found to have a schwannomas involving the labyrinth. In all cases, the inner ear lesions were preoperatively identified on magnetic resonance imaging, and the surgical removals were performed in all patients without serviceable hearing. The patients experienced improvement in their vertigo and tinnitus after surgery. Two patients were implanted the Bone-Anchored Hearing Aid (BAHA) to reconstruct the pseudo-stereophonic hearing. Conclusion: Intralabyrinthine schwannomas are the rare tumours in the otology. The tumour can be removed by surgical approach, but we do not propose surgical excision for the patients with serviceable hearing. BAHA can give patients a post-operative monaural pseudostereophonic hearing. (c) 2007 Elsevier Ireland Ltd. All rights reserved. C1 [Jia, Huan] Xinhua Hosp, Dept Otorhinolaryngol Head & Neck Surg, Shanghai, Peoples R China. [Jia, Huan; Marzin, Alexandre; DubreUil, Christian; Tringali, Stephane] Ctr Hosp Lyon Sud, Dept Otolaryngol Head & Neck Surg, Pierre Benite, France. RP Jia, H (reprint author), Xinhua Hosp, Dept Otorhinolaryngol Head & Neck Surg, Shanghai, Peoples R China. 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The amount of total saponins in the flower buds is higher than in any other parts of P. notoginseng. However, the compositions of flower buds have not been quantified clearly until now. A sensitive and efficient high-performance liquid chromatography-ultraviolet (HPLC-UV) method was developed for the first time to simultaneously quantify eight active saponins in the flower buds of P. notoginseng, including notoginsenoside R, and ginsenosides Rg(1), Re, Rb-1, Rb-2, Rb-3, Rd and F-2. The analysis was performed on a reversed-phase C-18 column with gradient elution of acetonitrile and 0.01% aqueous formic acid. The proposed method provided good linearity, reproducibility and sensitivity for the simultaneous quantification of the investigated saponins, with overall intra- and inter-day precision and accuracy of better than 4.1% (RSD) and higher than 95% (accuracy), respectively. The recoveries for all the saponins determined were in the range 94.7-104.8% with RSD better than 3.1%. Using the optimized method, we were able to analyze samples from different villages of Wenshan Prefecture, China, which is helpful for quality control of flower buds of P. notoginseng. Copyright (c) 2007 John Wiley & Sons, Ltd. C1 [Gao, Xianfu; Dan, Mo; Zhao, Aihua; Xie, Guoxiang; Jia, Wei] Shanghai Jiao Tong Univ, Sch Pharm, Shanghai 200240, Peoples R China. RP Jia, W (reprint author), Shanghai Jiao Tong Univ, Sch Pharm, 800 Dongchun Rd, Shanghai 200240, Peoples R China. EM weijia@sjtu.edu.cn RI Gao, Xianfu/C-7802-2009 CR Chen JC, 2001, AM J CHINESE MED, V29, P155, DOI 10.1142/S0192415X01000174 Fuzzati N, 1999, J CHROMATOGR A, V854, P69, DOI 10.1016/S0021-9673(99)00463-X Kwon SW, 2001, J CHROMATOGR A, V921, P335, DOI 10.1016/S0021-9673(01)00869-X Li L, 2005, J PHARMACEUT BIOMED, V38, P45, DOI 10.1016/j.jpba.2004.12.002 Liu J. 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PD MAR PY 2008 VL 22 IS 3 BP 244 EP 249 DI 10.1002/bmc.915 PG 6 WC Biochemical Research Methods; Biochemistry & Molecular Biology; Chemistry, Analytical; Pharmacology & Pharmacy SC Biochemistry & Molecular Biology; Chemistry; Pharmacology & Pharmacy GA 277WF UT WOS:000254244700004 PM 18004738 ER PT J AU Yaman, M Albayram, S Altintas, A Yeni, SN Karaagac, N Islak, C AF Yaman, M. Albayram, S. Altintas, A. Yeni, S. N. Karaagac, N. Islak, C. TI A cerebellar demyelinating lesion following treatment of acne with isotretinoin SO CLINICAL AND EXPERIMENTAL DERMATOLOGY LA English DT Article ID RETINOIC ACID; DIFFERENTIATION AB We report the case of a demyelinating lesion located in the left cerebellar region that developed 3 months after the onset of oral isotretionin treatment. In April 2001, 1 year before admission, the patient underwent cranial magnetic resonance imaging (MRI) because of endocrinological problems. This was found to be completely normal. In January 2002, oral isotretinoin treatment was started to treat severe acne. Three months after the onset of therapy, the patient reported lack of appetite, faintness and tinnitus. Her second cranial MRI scan showed a cerebellar lesion, and oral isotretinoin treatment was stopped (April 2002). One month after the cessation of oral isotretinoin treatment, the lesion became less prominent on the MRI scan, and after 3 months, it had disappeared. Although it is difficult to determine the causal association between the demyelinating cerebellar lesion and isotretinoin treatment, we would like to alert physicians to this possibility, because of the common usage of this drug in daily practice. C1 [Yaman, M.; Albayram, S.; Altintas, A.; Yeni, S. N.; Karaagac, N.; Islak, C.] Afyon Kocatepe Univ, Fac Med, Dept Neurol, TR-03200 Pembe Hastane, Ayon, Turkey. [Albayram, S.; Islak, C.] Istanbul Univ, Dept Radiol, Cerrahpasa Fac Med, Istanbul, Turkey. [Altintas, A.; Yeni, S. N.; Karaagac, N.] Istanbul Univ, Dept Neurol, Cerrahpasa Fac Med, Istanbul, Turkey. RP Yaman, M (reprint author), Afyon Kocatepe Univ, Fac Med, Dept Neurol, TR-03200 Pembe Hastane, Ayon, Turkey. EM yaman@aku.edu.tr CR Goodman AB, 1998, P NATL ACAD SCI USA, V95, P7240, DOI 10.1073/pnas.95.13.7240 LAMMER EJ, 1985, NEW ENGL J MED, V313, P837, DOI 10.1056/NEJM198510033131401 MALIK MA, 2003, J NUTR BIOCH, V11, P2 McCaffery P, 2000, CYTOKINE GROWTH F R, V11, P233, DOI 10.1016/S1359-6101(00)00002-2 NOLL E, 1994, DEVELOPMENT, V120, P649 PRITCHARD J, 2004, BRIT MED J, V26, P1537 RACKE MK, 1995, J IMMUNOL, V154, P450 SADICK N, 1986, CUTIS, V38, P29 Slack JL, 1999, CANC TREAT, V99, P75 Vergelli M, 1997, IMMUNOPHARMACOLOGY, V37, P191, DOI 10.1016/S0162-3109(97)00048-9 NR 10 TC 4 Z9 4 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 0307-6938 J9 CLIN EXP DERMATOL JI Clin. Exp. Dermatol. PD MAR PY 2008 VL 33 IS 2 BP 118 EP 121 DI 10.1111/j.1365-2230.2007.02429.x PG 4 WC Dermatology SC Dermatology GA 258VD UT WOS:000252896700002 PM 17501969 ER PT J AU Williams, VG Tremont, G Blum, AS AF Williams, Vanessa G. Tremont, Geoffrey Blum, Andrew S. TI Musical hallucinations after left temporal lobectomy SO COGNITIVE AND BEHAVIORAL NEUROLOGY LA English DT Article DE musical hallucinations; temporal lobectomy; epilepsy ID AUDITORY HALLUCINATIONS; PREVALENCE; PHENOMENOLOGY; BRAIN; SPECTRUM; DEAFNESS; IMAGERY AB Background: Musical hallucinations (MHs) are rare and most often described in patients with hearing loss, female sex, older age, and various brain pathologies, including epilepsy. Case History: We describe a unique case in which, after successful left temporal lobectomy for refractory epilepsy and subsequent ototoxic therapies, a 49-year-old man experienced the onset of songs replaying constantly in his mind for days to weeks. He had intractable partial epilepsy since age 26. Presurgical neurodiagnostic evaluations revealed a left temporal focus, left hippocampal magnetic resonance imaging abnormalities, bilateral language representation, and cognitive deficits lateralized to the left hemisphere. He underwent a partial left temporal lobectomy but required repeated antibiotic courses for postoperation bone flap infections, resulting in tinnitus. Surgery led to near seizure-freedom, plus improved cognitive and emotional function. Pathology revealed focal cortical dysplasia. Six months postsurgery, during antibiotic treatment, he began to hear songs replaying in his head, which increased in frequency over ensuing years. Conclusions: We report, to our knowledge, the first case of MHs associated with temporal lobectomy for epilepsy. This patient had multiple risk factors for these unwanted musical experiences, including epilepsy, mild neuropsychiatric dysfunction, and tinnitus plus hearing loss. Possible mechanisms for MHs are discussed. C1 [Williams, Vanessa G.; Tremont, Geoffrey] Brown Univ, Warren Alpert Med Sch, Dept Psychiat & Human Behav, Providence, RI 02912 USA. [Blum, Andrew S.] Brown Univ, Warren Alpert Med Sch, Dept Clin Neurosci, Providence, RI 02912 USA. [Williams, Vanessa G.; Tremont, Geoffrey; Blum, Andrew S.] Rhode Isl Hosp, Comprehens Epilepsy Program, Providence, RI 02903 USA. RP Tremont, G (reprint author), Rhode Isl Hosp, Neuropsychol Program, 593 Eddy St, Providence, RI 02903 USA. 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Behav. Neurol. PD MAR PY 2008 VL 21 IS 1 BP 38 EP 40 PG 3 WC Behavioral Sciences; Clinical Neurology SC Behavioral Sciences; Neurosciences & Neurology GA 281NB UT WOS:000254503200008 PM 18327022 ER PT J AU Wall, M AF Wall, Michael TI Idiopathic intracranial hypertension (pseudotumor cerebri) SO CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS LA English DT Review ID NERVE SHEATH DECOMPRESSION; CSF OPENING PRESSURE; BODY-MASS INDEX; REFERENCE INTERVAL; TUMOR CEREBRI; WEIGHT-LOSS; ACETAZOLAMIDE; OBESITY; FENESTRATION; HEADACHE AB Idiopathic intracranial hypertension (IIH), also known as pseudotumor cerebri, is a disorder of elevated intracranial pressure of unknown cause. Patients present with daily headache, pulse-synchronous tinnitus, transient visual obscurations, papilledema with its associated visual loss, and diplopia from sixth nerve paresis. Many disease associations have been alleged, but few besides obesity, hypervitaminosis A and related compounds, steroid withdrawal, and female gender have been proven. Although absorption of cerebrospinal fluid (CSF) occurs through arachnoid granulations and extracranial lymphatics, out flow resistance is increased in IIH; therefore, intracranial pressure must increase for CSF to be absorbed. The mainstays of medical treatment are a reduced-sodium weight-reduction program and acetazolamide. If patients fail medical therapy, surgical procedures, most commonly optic nerve sheath fenestration and CSF shunting, are employed. The main morbidity of IIH is visual loss. This is present in most patients and can usually be reversed if recognized early in the course of the disease and treated. C1 Univ Iowa, Carver Coll Med, Vet Adm Hosp, Iowa City, IA 52242 USA. RP Wall, M (reprint author), Univ Iowa, Carver Coll Med, Vet Adm Hosp, 200 CMAB, Iowa City, IA 52242 USA. 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Neurol. Neurosci. Rep. PD MAR PY 2008 VL 8 IS 2 BP 87 EP 93 DI 10.1007/s11910-008-0015-0 PG 7 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA 307LB UT WOS:000256319300001 PM 18460275 ER PT J AU Belli, S Belli, H Bahcebasi, T Ozcetin, A Alpay, E Ertem, U AF Belli, Seyda Belli, Hasan Bahcebasi, Talat Ozcetin, Adnan Alpay, Emrehan Ertem, Umit TI Assessment of psychopathological aspects and psychiatric comorbidities in patients affected by tinnitus SO EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY LA English DT Article DE tinnitus; psychiatric comorbidity; anxiety; depression; somatization ID DEPRESSION; INVENTORY AB The aim of present study was to determine the psychiatric symptoms and comorbidities in patients affected by tinnitus. The study sample, between June 2004 and September 2005, consisted of 180 Turkish adults living in Elazig. Ninety consecutive tinnitus patients were enrolled on their first visit to the outpatients clinic. Control subjects were recruited partly from the social surroundings of the authors. All subjects with significant medical and/or psychiatric pathologies, such as schizophrenia, manic-depressive psychosis, dementia, and behavioural disorders with social withdrawal or suicidal risk, were excluded, as were those unwilling to take part in the study. For the psychopathological examination, patients underwent the Structured Clinical Interview for DSM-III-R (SCID-I, SCID-II). Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI), Symptom Check list-90 (Revised) (SCL-90-R) were also administered to patients with tinnitus and control subjects. SCL-90-R subscales scores, Beck Anxiety Inventory and Beck Depression Inventory scores were significantly higher in tinnitus patients than in normal control subjects. Twenty-four patients (26.70%) with tinnitus had at least one psychiatric diagnosis. Five control subjects (5.60%) had at least one psychiatric diagnosis. There were significant differences between the two groups (P < 0.001). Anxiety disorders and somatoform disorders were significantly higher in tinnitus patients than in normal control subjects. We conclude that psychiatric symptoms (such as symptoms of anxiety, depression or somatization) among patients with tinnitus should alert clinicians for the presence of a chronic and complex psychiatric condition (Axis-I and Axis-II disorders). C1 [Belli, Seyda] Elazig Kovancilar State Hosp, Dept Otolaryngol, Elazig, Turkey. [Belli, Hasan; Ertem, Umit] Elazig Mental Hlth Hosp, Dept Psychiat, Elazig, Turkey. [Ozcetin, Adnan] Abant Izzet Baysal Univ Duzce, Fac Med, Dept Psychiat, Duzce, Turkey. [Alpay, Emrehan] Elazig State Hosp, Elazig, Turkey. RP Belli, S (reprint author), Elazig Kovancilar Devlet Hastanesi, TR-23100 Kovancilar, Turkey. 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Arch. Oto-Rhino-Laryn. PD MAR PY 2008 VL 265 IS 3 BP 279 EP 285 DI 10.1007/s00405-007-0440-8 PG 7 WC Otorhinolaryngology SC Otorhinolaryngology GA 257KU UT WOS:000252798800003 PM 17999075 ER PT J AU Marcon, S Patuzzi, R AF Marcon, Simon Patuzzi, Robert TI Changes in cochlear responses in guinea pig with changes in perilymphatic K+. Part 1: Summating potentials, compound action potentials and DPOAEs SO HEARING RESEARCH LA English DT Article DE potassium; compound action potential; summating potential; distortion product; tinnitus; deafness ID OUTER HAIR-CELLS; AUDITORY-NERVE FIBERS; POTASSIUM CONCENTRATION; VOLUME REGULATION; CAT; ACETYLCHOLINE; MECHANISM; PERFUSION; RUBIDIUM AB We have measured the effects of changing perilymphatic K+ by perfusing Scala tympani in guinea pigs with salt solutions high or low in K+, while monitoring the distortion product otoacoustic emissions (DPOAEs) in the ear canal (a measure of mechanical vibration of the organ of Corti), the summating potential (SP) evoked by high-frequency tone-bursts (taken to be a measure of pre-synaptic electrical activity of the inner hair cells) and the compound action potential (CAP) of the auditory nerve (taken to be a measure of post-synaptic neural activity). We have attempted to investigate the osmotic effects of our perfusates by comparison with simple hyperosmotic sucrose perfusates and iso-osmotic versions of perfusates, and for the effects of changes in other ions (e.g. Na+ and Cl-) by keeping these constant in some perfusates while elevating K+. We have found that changing the K+ concentration over the range 0-30 mM elevated the SP and CAP thresholds almost equally in normal animals, and not at all in animals devoid of outer hair cells (OHCs), showing that OHCs are sensitive to the perfusates we have used, but the inner hair cells (IHCs) and the type I afferent dendrites are not, presumably because IHCs are shielded from perilymph by supporting cells, and the membranes of the afferent dendrite membranes exposed directly to our perfusates are dominated by Cl- permeability, rather than by K+ permeability. This view is supported by experiments in which the perilymphatic Cl- concentration was reduced, producing a large elevation in CAP threshold, but a much smaller elevation of SP threshold, suggesting disruption of action potential initiation. The view that threshold elevations with changes in perilymphatic K+ are due almost solely to a disruption of OHC function and a consequent change in the mechanical sensitivity of the organ of Corti was supported by measurements of amplitude of the 2f(1)-f(2) distortion product otoacoustic emission. During elevations in K+, DPOAEs followed a similar time-course to that for SP and CAP, although the changes were less for DPOAEs. The lack of a 1:1 relationship between DPOAEs and SP and CAP is probably because the iso-input DPOAE measure used is a more complex indicator of mechanical sensitivity than the iso-output measure used by others. Taken together, these results suggest that changes in K+ in pathological conditions probably produce a hearing loss by disrupting IHCs rather than OHC or neurotics, and that OHC disruption in our experiments was due to a mixture of osmotic, K+ and possibly Cl- effects. (C) 2008 Elsevier B.V. All rights reserved. C1 Univ Western Australia, Sch Biomed Biomol & Chem Sci, Nedlands, WA 6009, Australia. RP Patuzzi, R (reprint author), Univ Western Australia, Sch Biomed Biomol & Chem Sci, 35 Stirling Highway, Nedlands, WA 6009, Australia. 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Res. PD MAR PY 2008 VL 237 IS 1-2 BP 76 EP 89 DI 10.1016/j.heares.2007.12.011 PG 14 WC Audiology & Speech-Language Pathology; Neurosciences; Otorhinolaryngology SC Audiology & Speech-Language Pathology; Neurosciences & Neurology; Otorhinolaryngology GA 289IU UT WOS:000255049000007 PM 18262371 ER PT J AU Seydel, C Georgiewa, P Reisshauer, A Klapp, BF Mazurek, B AF Seydel, C. Georgiewa, P. Reisshauer, A. Klapp, B. F. Mazurek, B. TI Group therapeutic concept for chronic tinnitus SO HNO LA German DT Article DE chronic tinnitus; psychological therapy; group therapy; neurophysiological model ID RETRAINING THERAPY; VARIABLES AB The aim of this article is to show an established group therapeutic concept for chronic tinnitus. The treatment of chronic tinnitus is intended to improve the way patients cope with tinnitus but it does not eliminate it. It means that patients learn how to reduce the impairment they are experiencing. Patients with tinnitus are supported in the process of habituation through the treatment. Multimodal cognitive behavioral therapeutic interventions in a group setting are particularly helpful because they may demonstrate differences in the influence of cognitive processes on the emotional perception of the tinnitus between the patients. Psychological factors like emotional support through other patients and learning from other examples can ease the process of internalizing coping strategies. Psychological processes seem to be of particular importance. Those processes can have an effect on concentration, appraisal, and coping with the tinnitus. Progressive muscle relaxation using Jacobson's technique, physical therapy, education via lectures, training of selective attention and change of appraisal, mental attitude and behavior concerning the tinnitus are the main factors in tinnitus therapy and can enable tinnitus patients to decrease their psychological strain. C1 [Mazurek, B.] Univ Med Berlin, Charite, HNO Klin & Poliklin, Tinnituszentrum, D-10117 Berlin, Germany. [Seydel, C.; Georgiewa, P.; Klapp, B. F.] Univ Med Berlin, Charite, Med Klin Schwerpunkt Psychosomat, D-10117 Berlin, Germany. RP Mazurek, B (reprint author), Univ Med Berlin, Charite, HNO Klin & Poliklin, Tinnituszentrum, Charitepl 1, D-10117 Berlin, Germany. EM birgit.mazurek@charite.de CR BIESINGER E, 1999, BEHANDLUNG OHRGERAUS Biesinger E, 1998, HNO, V46, P157, DOI 10.1007/s001060050215 Budd RJ, 1996, J PSYCHOSOM RES, V41, P327, DOI 10.1016/S0022-3999(96)00171-7 DECAMPSCHMIDT E, 1992, OHRGERAUSCHE PSYCHOS, P179 Delb W, 2002, HNO, V50, P997, DOI 10.1007/s00106-002-0645-5 Frenzel A., 1998, CHRONISCHER TINNITUS GOEBEL G, 1992, OHRGERAUSCHE PSYCHOS GOEBEL G, 1995, VERHALTENSMEDIZINI 3, V3, P239 Goebel G, 1999, VERHALTENSTHERAPIE, V9, P20 GOEBEL G, 1999, INTERN PRAX, V39, P549 GOEBEL G, 1998, TINNITUSFRAGEBOGEN T GOEBEL G, 1989, VERHALTENSTHERAPIE M, P207 Greimel KV, 1999, HNO, V47, P130, DOI 10.1007/s001060050372 GREIMEL KV, 2000, RETRAINING TINNITUST, P36 Hallam R. S, 1987, TINNITUS, P156 HALLAM RS, 1988, BRIT J CLIN PSYCHOL, V27, P213 Hesse G, 2002, HNO, V50, P973, DOI 10.1007/s00106-002-0739-0 Hesse G, 2001, HNO, V49, P764, DOI 10.1007/s001060170052 HESSE G, 2000, RETRAINING TINNITUST Jastreb off P. J., 1999, P 6 INT TINN SEM CAM, P32 KROENERHERWIG B, 1997, PSYCHOL BEHANDLUNG C SCHAAF H, 2002, PSYCHOTHERAPIE BEI T SCHNEIDER WR, 1994, HNO, V42, P22 von Wedel H, 2000, HNO, V48, P887, DOI 10.1007/s001060050685 WALSH WM, 1985, LARYNGOSCOPE, V95, P987 Weber C, 2002, J PSYCHOSOM RES, V52, P29, DOI 10.1016/S0022-3999(01)00281-1 WHITE TP, 1986, EAR HEARING, V7, P397, DOI 10.1097/00003446-198612000-00009 Zenner HP, 2003, HNO, V51, P687, DOI 10.1007/s00106-003-0939-2 NR 28 TC 0 Z9 0 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013 USA SN 0017-6192 J9 HNO JI HNO PD MAR PY 2008 VL 56 IS 3 BP 332 EP + DI 10.1007/s00106-007-1639-0 PG 7 WC Otorhinolaryngology SC Otorhinolaryngology GA 270YR UT WOS:000253756600013 PM 18066513 ER PT J AU Subashini, P Mohanty, S AF Subashini, P. Mohanty, Sanjeev TI Altered clinical course of glomus tympanicum - a case report SO INDIAN JOURNAL OF OTOLARYNGOLOGY AND HEAD & NECK SURGERY LA English DT Article DE Glomus tympanicum; Hearing loss; Magnetic Resonance Imaging (MRI) ID TUMOR AB Glomus tumours of temporal bone are rare and usually present with symptoms of hearing loss and tinnitus. Diagnosis is often delayed due to the slow growth of the tumour. Here we present a case report of a patient diagnosed as glomus tympanicum who presented only with unilateral progressive hearing loss for the past one year and rapidly detoriating hearing loss since two months who was managed successfully. C1 [Mohanty, Sanjeev] Sri Ramachandra Med Coll & Res Inst, Dept ENT & Head & Neck Surg, Madras 600116, Tamil Nadu, India. [Subashini, P.; Mohanty, Sanjeev] Sri Ramachandra Med Coll & Res Inst, Dept Otolaryngol Head & Neck Surg, Madras 600116, Tamil Nadu, India. RP Subashini, P (reprint author), Sri Ramachandra Med Coll & Res Inst, Dept ENT & Head & Neck Surg, Madras 600116, Tamil Nadu, India. CR BATSAKIS JG, 1979, PARAGANGLIOMAS HEAD, P369 CHEESMAN AD, 2003, S BROWNS OTOLARYNGOL GULYA AJ, 1979, LARYNGOSCOPE, V103, P7 HEUTINK P, 1992, HUM MOL GENET, V1, P7, DOI 10.1093/hmg/1.1.7 Seymour FK, 2004, J LARYNGOL OTOL, V118, P234 TSUNEYOSHI M, 1982, CANCER, V50, P1601, DOI 10.1002/1097-0142(19821015)50:8<1601::AID-CNCR2820500823>3.0.CO;2-5 NR 6 TC 0 Z9 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0019-5421 J9 INDIAN J OTOLARYNGOL JI Indian J. Otolaryngol. Head Neck Surg. PD MAR PY 2008 VL 60 IS 1 BP 35 EP 36 DI 10.1007/s12070-008-0011-3 PG 2 WC Otorhinolaryngology SC Otorhinolaryngology GA 419JK UT WOS:000264215400008 PM 23120495 ER PT J AU Premaratna, R Loftis, AD Chandrasena, TGAN Dasch, GA de Silva, HJ AF Premaratna, R. Loftis, A. D. Chandrasena, T. G. A. N. Dasch, G. A. de Silva, H. J. TI Rickettsial infections and their clinical presentations in the Western Province of Sri Lanka: a hospital-based study SO INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES LA English DT Article DE scrub typhus; spotted fever group rickettsioses; Sri Lanka ID SCRUB TYPHUS; SOUTHERN INDIA AB Background: Rickettsial. infections are re-emerging. A study of the geographical distribution of rickettsial. infections, their clinical manifestations, and their complications would facilitate early diagnosis. Methods: Thirty-one selected patients from the Western Province of Sri Lanka were studied for rickettsial species, clinical manifestations, and complications. Results: Of 31 patients with possible rickettsioses, 29 (94%) felt into the categories of confirmed, presumptive, or exposed cases of acute rickettsia[ infections (scrub typhus was diagnosed in 19 (66%), spotted fever group in eight (28%)). Early acute infection or past exposure was suggested in two (7%) cases; cross-reactivity of antigens or past exposure to one or more species was suggested in nine (31%). Seventeen out of 19 (89%) patients with scrub typhus had eschars. Nine out of 29 (32%) patients had a discrete erythematous papular rash: seven caused by spotted fever group, two by scrub typhus. Severe complications were pneumonitis in eight (28%), myocarditis in five (17%), deafness in four (14%), and tinnitus in two (7%). The mean duration of illness before onset of complications was 12.0 (SD 1.4) days. All patients except one made a good clinical recovery with doxycycline or a combination of doxycycline and chloramphenicol. Conclusions: In a region representing the low country wet zone of Sri Lanka, the main rickettsial. agent seems to be Orientia tsutsugamushi. Delay in diagnosis may result in complications. All species responded well to current treatment. (c) 2007 Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. C1 [Premaratna, R.; de Silva, H. J.] Univ Kelaniya, Fac Med, Dept Med, Ragama, Sri Lanka. [Loftis, A. D.; Dasch, G. A.] Ctr Dis Control & Prevent, Viral & Rickettsial Zoonoses Branch, Atlanta, GA 30333 USA. [Chandrasena, T. G. A. N.] Univ Kelaniya, Fac Med, Dept Parasitol, Ragama, Sri Lanka. RP Premaratna, R (reprint author), Univ Kelaniya, Fac Med, Dept Med, POB 6,Thalagolia Rd, Ragama, Sri Lanka. EM ranjan_premaratna@lycos.com CR CHENCHITTIKUL M, 1995, J MED TECH ASS THAI, V23, P55 Cowan G, 2000, POSTGRAD MED J, V76, P269, DOI 10.1136/pmj.76.895.269 COWAN GO, 1996, MANSONS TROPICAL DIS, P797 DASSANAYAKE AS, 2001, P SRI LANK MED ASS S, V33 Isaac R, 2004, CLIN INFECT DIS, V39, P1395, DOI 10.1086/424748 Kularatne SAM, 2003, TROP MED INT HEALTH, V8, P803, DOI 10.1046/j.1365-3156.2003.01108.x Mathai E, 2003, ANN NY ACAD SCI, V990, P359 Premaratna R, 2006, Clin Infect Dis, V42, pe6, DOI 10.1086/498747 Silpapojakul Khachornsakdi, 1997, Annals Academy of Medicine Singapore, V26, P794 SUPANARANOND WAT, 2004, J TROP MED PUBLIC HL, V35, P845 Tay S. T., 2002, Southeast Asian Journal of Tropical Medicine and Public Health, V33, P557 Van Peenen PFD, 1976, SE ASIAN J TROPICAL, V7, P16 Watt G, 1996, LANCET, V348, P86, DOI 10.1016/S0140-6736(96)02501-9 Wong S. Y., 2001, SMJ Singapore Medical Journal, V42, P546 Yang Ching-Huei, 1995, Journal of the Formosan Medical Association, V94, P101 NR 15 TC 20 Z9 20 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1201-9712 J9 INT J INFECT DIS JI Int. J. Infect. Dis. PD MAR PY 2008 VL 12 IS 2 BP 198 EP 202 DI 10.1016/j.ijid.2007.06.009 PG 5 WC Infectious Diseases SC Infectious Diseases GA 272IW UT WOS:000253854100018 PM 17900956 ER PT J AU Seidman, MD De Ridder, D Elisevich, K Bowyer, SM Darrat, I Dria, J Stach, B Jiang, Q Tepley, N Ewing, J Seidman, M Zhang, J AF Seidman, Michael D. De Ridder, Dirk Elisevich, Kost Bowyer, Susan M. Darrat, Ilaaf Dria, Jason Stach, Brad Jiang, Quan Tepley, Norman Ewing, James Seidman, Marlee Zhang, Jinsheng TI Direct Electrical Stimulation of Heschl's Gyrus for Tinnitus Treatment SO LARYNGOSCOPE LA English DT Article; Proceedings Paper CT COSM 2005 Conference CY MAY 15, 2005 CL Boca Raton, FL SP COSM DE Tinnitus; fMRI; MEG; direct electrical stimulation ID VASCULAR-DECOMPRESSION SURGERY; DORSAL COCHLEAR NUCLEUS; HUMAN AUDITORY-CORTEX; INTRACTABLE TINNITUS; INTENSE SOUND; GUINEA-PIGS; SUPPRESSION; PLASTICITY; PROJECTIONS; EPILEPSY AB Objectives/Hypothesis: The purpose of the study was to determine the effect of electrical stimulation of the auditory cortex in patients with tinnitus. Study Design: Nonrandomized clinical trial. Methods: Two patients with debilitating tinnitus refractory to conventional therapies were treated. Patients were evaluated with validated questionnaires and psychoacoustic measures to determine the frequency and pitch of their tinnitus. Tones at these frequencies were then presented to the first patient (RP) under magnetoen-cephalography (MEG) and functional magnetic resonance imaging (fMRI) to determine the tonotopic map for these frequencies in Heschl's gyrus. These tonotopic sites were targeted for implant with a quadripolar electrode. In the second patient (MV), only the fMRI tonotopic map was performed. These fMRI results detected an area of increased activity, which was selected as the site for the implanted bipolar electrode. Results: Patient RP (bilateral tinnitus for 2 years) has experienced a sustained reduction to near elimination of tinnitus with intracerebral. implanted electrodes, whereas patient MV (unilateral tinnitus for 7 years) had an unsustained reduction in her tinnitus. Conclusion: These findings suggest that the perception and annoyance of tinnitus may be modulated or reduced through electrical stimulation of the auditory cortex. These unsustained effects for patient MV may have been influenced by the longstanding nature of her tinnitus or by another reason as yet undetermined. C1 [Seidman, Michael D.; Elisevich, Kost; Bowyer, Susan M.; Darrat, Ilaaf; Dria, Jason; Stach, Brad; Jiang, Quan; Tepley, Norman; Ewing, James] Henry Ford Hlth Syst, Dept Otolaryngol Head & Neck Surg, Detroit, MI USA. [Seidman, Michael D.; Elisevich, Kost; Bowyer, Susan M.; Darrat, Ilaaf; Dria, Jason; Stach, Brad; Jiang, Quan; Tepley, Norman; Ewing, James] Henry Ford Hlth Syst, Dept Neurol, W Bloomfield, MI 48323 USA. [Seidman, Marlee] Towson Univ, Towson, MD USA. [Zhang, Jinsheng] Wayne State Univ, Dept Otolaryngol Head & Neck Surg, Detroit, MI USA. [Bowyer, Susan M.] Wayne State Univ, Dept Neurol, Detroit, MI USA. [De Ridder, Dirk] Univ Antwerp Hosp, Dept Neurosurg, Antwerp, Belgium. RP Seidman, MD (reprint author), Henry Ford Hlth Syst, Div Otolog Neurotol Surg, 6777 W Maple Rd, W Bloomfield, MI 48323 USA. 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Shaibini, Ali Russell, Eric J. Walker, Matthew T. TI Persistent trigeminal artery terminating in the posterior inferior cerebellar artery: Case report SO NEUROSURGERY LA English DT Article DE persistent trigeminal artery; Saltzman classification; vascular anomalies AB OBJECTIVE: Persistent trigeminal arteries are rare and represent a remnant of the fetal carotid-basilar circulation. They typically extend from the internal carotid artery to the basilar artery. An unusual case of a patient with a trigeminal artery originating from the internal carotid artery and terminating as the dominant hemispheric branch of the posterior inferior cerebellar artery is presented. CLINICAL PRESENTATION: A 66-year-old woman presented to the emergency department with pulsatile tinnitus, increasing left eye pain, proptosis, conjunctival injection, diplopia, and decreased visual acuity. Conventional contrast-enhanced computed tomographic and magnetic resonance imaging demonstrated findings consistent with a left carotid-cavernous fistula. The patient underwent an emergency diagnostic cerebral angiogram. Besides an indirect carotid-cavernous fistula on the left side, a right-sided persistent trigeminal artery terminating as the dominant hemispheric trunk of the posteroinferior cerebellar artery was incidentally noted. The vermian branch of the right posteroinferior cerebellar artery arose from the ipsilateral vertebral artery, whereas duplicate superior cerebellar arteries supplied the left posteroinferior cerebellar artery region. INTERVENTION: The patient was treated for the indirect carotid-cavernous fistula with detachable platinum coils and N-butyl cyanoacrylate, resulting in the resolution of her symptoms. CONCLUSION: We report a case of a persistent trigeminal artery supplying only the cerebellar hemisphere. The clinical significance of this anomaly relates to its role in endovascular therapeutic and surgical complications and the paradoxical lesions in the cerebellum that occur as a result of carotid disease. We also discuss the Saltzman classification of persistent trigeminal arteries and their variants. C1 [Ali, Saad; Radaideh, Majdi M.; Shaibini, Ali; Russell, Eric J.; Walker, Matthew T.] Northwestern Univ, Dept Radiol, Neuroradiol Sect, Feinberg Sch Med, Chicago, IL 60611 USA. RP Ali, S (reprint author), Northwestern Univ, Dept Radiol, Neuroradiol Sect, Feinberg Sch Med, Chicago, IL 60611 USA. NR 0 TC 12 Z9 13 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0148-396X J9 NEUROSURGERY JI Neurosurgery PD MAR PY 2008 VL 62 IS 3 BP 746 EP 748 DI 10.1227/01.NEU.0000297127.23313.C6 PG 3 WC Clinical Neurology; Surgery SC Neurosciences & Neurology; Surgery GA 292LV UT WOS:000255268500049 ER PT J AU Yerdelen, D Koc, F AF Yerdelen, Deniz Koc, Filiz TI Vascular compression of multiple cranial nerves - The clinical syndromes SO NEUROSURGERY QUARTERLY LA English DT Article DE vascular compression of 5, 7, and 8 cranial nerves; facial pain; vertigo and tinnitus ID HEMIFACIAL SPASM; TRIGEMINAL NEURALGIA; NEUROVASCULAR COMPRESSION; ESSENTIAL-HYPERTENSION; VERTEBRAL ARTERY; FACIAL-PAIN; DECOMPRESSION AB Abnormal changes such as loops, tortuosity, and ectasia in vascular structures that form vertebrobasilar system can cause mechanical vascular-compression syndromes. Neurologic symptoms might be encountered by compression of one or more of these cranial nerves. The compression of 3 nerves together has not been reported in the literature. Here, we present a patient with facial pain, vertigo, and tinnitus associated with the vascular compression of 5, 7, and 8 cranial nerves. A 52-year-old man was admitted to the clinic with complaints of pain located in the left upper part of face, with tinnitus being prominent on the left, and positional vertigo developing occasionally. The physical and neurologic examinations were normal. Cerebral magnetic resonance imaging and magnetic resonance angiography showed tortuosity in both the vertebral arteries and in the basilar artery, as well as the external compression of trigeminal 5, 7, and 8 nerve complexes by the intradural segment of the left vertebral artery. Internal acoustic channel magnetic resonance imaging revealed the compression of the 7 and 8 nerve complexes by the left basilar artery. C1 [Yerdelen, Deniz] Baskent Univ, Dept Neurol, Fac Med, Adana Teaching & Res Ctr, TR-01250 Adana, Turkey. [Koc, Filiz] Cukurova Univ, Fac Med, Dept Neurol, Adana, Turkey. RP Yerdelen, D (reprint author), Baskent Univ, Dept Neurol, Fac Med, Adana Teaching & Res Ctr, Dadaloglu Mah,39 Sok, TR-01250 Adana, Turkey. 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Q. PD MAR PY 2008 VL 18 IS 1 BP 69 EP 71 PG 3 WC Neurosciences; Surgery SC Neurosciences & Neurology; Surgery GA 273MW UT WOS:000253936000014 ER PT J AU Lee, SL Abraham, M Cacace, AT Silver, SM AF Lee, Scott L. Abraham, Megan Cacace, Anthony T. Silver, Steven M. TI Repetitive transcranial magnetic stimulation in veterans with debilitating tinnitus: A pilot study SO OTOLARYNGOLOGY-HEAD AND NECK SURGERY LA English DT Article; Proceedings Paper CT 111th Annual Meeting of the American-Academy-of-Otolaryngology-Head-and-Neck-Surgery-Foundation CY SEP 16-19, 2007 CL Washington, DC SP Amer Acad Otolaryngol Head & Neck Surg Fdn AB OBJECTIVE: Available evidence suggests tinnitus arises from excessive spontaneous activity in the left superior temporal gyrus, and repetitive transcranial magnetic stimulation (rTMS) may suppress this activity. Our hypothesis is that rTMS applied to this region would decrease tinnitus complaints in veterans. STUDY DESIGN: Prospective, nonrandomized trial. SUBJECTS AND METHODS: Eight patients with tinnitus received 5 consecutive days of rTMS (0.5 Hz, 20 minutes) to the left temporoparietal area. Tinnitus Handicap Inventory (THI) measures before sessions I and 3 and after session 5 were used to evaluate efficacy. RESULTS: Patient 1's THI decreased 40 to 34 to 26, patient 4 reported a subjective improvement, patient 8 withdrew, and the remaining patients reported no improvement. Adverse effects included temporary soreness, restlessness, and photophobia. CONCLUSION: The parameters for this rTMS study are different from those that reported success with its use. With these current parameters. rTMS did not improve tinnitus in veterans. There were no permanent adverse outcomes. (c) 2008 American Academy of Otolaryngology-Head and Neck Surgery Foundation. All rights reserved. C1 [Lee, Scott L.; Silver, Steven M.] Albany Med Coll, Div Otolaryngol Head & Neck Surg, Albany, NY 12208 USA. [Abraham, Megan] Union Coll, Schenectady, NY 12308 USA. [Silver, Steven M.] Stratton VA Med Ctr, Div Otolaryngol Head & Neck Surg, Albany, NY USA. [Cacace, Anthony T.] Wayne State Univ, Dept Commun Sci & Disorders, Detroit, MI USA. RP Lee, SL (reprint author), Albany Med Coll, Div Otolaryngol Head & Neck Surg, MC-41,47 New Scotland Ave, Albany, NY 12208 USA. EM leesl@mail.amc.edu CR Arnold W, 1996, ORL J OTO-RHINO-LARY, V58, P195 Eichhammer P, 2003, BIOL PSYCHIAT, V54, P862, DOI 10.1016/S0006-3223(03)01896-6 HENRY JA, 2005, SNOW JBTINNITUS THEO, P337 Kleinjung T, 2005, OTOLARYNG HEAD NECK, V132, P566, DOI 10.1016/j.otohns.2004.09.134 Newman CW, 1996, ARCH OTOLARYNGOL, V122, P143 NR 5 TC 16 Z9 17 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0194-5998 J9 OTOLARYNG HEAD NECK JI Otolaryngol. Head Neck Surg. PD MAR PY 2008 VL 138 IS 3 BP 398 EP 399 DI 10.1016/j.otohns.2007.11.035 PG 2 WC Otorhinolaryngology; Surgery SC Otorhinolaryngology; Surgery GA 270CA UT WOS:000253696300026 PM 18312892 ER PT J AU Liu, XP Goldring, CEP Wang, HY Copple, IM Kitteringharn, NR Park, BK Wei, W AF Liu, Xiao-Ping Goldring, Christopher E. P. Wang, Hai-Yi Copple, Ian M. Kitteringharn, Neil R. Park, B. Kevin Wei, Wei TI Extract of Ginkgo biloba induces glutamate cysteine ligase catalytic subunit (GCLC) SO PHYTOTHERAPY RESEARCH LA English DT Article DE extract of Ginkgo biloba; GCLC; herb ID GAMMA-GLUTAMYLCYSTEINE SYNTHETASE; ALVEOLAR EPITHELIAL-CELLS; HEAVY SUBUNIT; ANTIOXIDANT RESPONSE; GLUTATHIONE SYNTHESIS; INDUCTION; GENE; EXPRESSION; ASSIGNMENT; SEQUENCE AB The extract of Ginkgo biloba (EGb), containing 24% flavone glycosides and 6% terpenoids, is widely used to treat early-stage Alzheimer's disease, vascular dementia, peripheral claudication and vascular tinnitus. Its marked antioxidant activity has recently been demonstrated in both cell lines and animals. Glutathione (GSH) plays an important role in the antioxidant system by conjugating to xenobiotics to facilitate their export from cells. Glutamate cysteine ligase (GCL) is the rate-limiting enzyme for GSH synthesis and its catalytic subunit (GCLC) determines this de novo synthesis. Thus, induction of GCLC is a strategy to enhance the antioxidant capability in cells. The present study aimed to investigate the induction effect of EGb on GCLC in HepG2 and Hep1c1c7 cell lines. Real-time PCR, Western blot and enzyme activity assay were used to detect induction and it was found that GCLC was induced by EGb in these two cell lines. It is suggested that the antioxidant activity of EGb is (or is partly) through the induction of GCLC. Copyright (C) 2007 John Wiley & Sons, Ltd. C1 [Liu, Xiao-Ping; Wei, Wei] Anhui Med Univ, Inst Clin Pharmacol, Hefei 230032, Anhui, Peoples R China. [Liu, Xiao-Ping] Wannan Med Coll, Dept Pharmacol, Wuhan, Anhui, Peoples R China. [Goldring, Christopher E. P.; Wang, Hai-Yi; Copple, Ian M.; Park, B. Kevin] Univ Liverpool, Dept Pharmacol & Therapeut, Liverpool L69 3BX, Merseyside, England. RP Wei, W (reprint author), Anhui Med Univ, Inst Clin Pharmacol, Hefei 230032, Anhui, Peoples R China. 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Res. PD MAR PY 2008 VL 22 IS 3 BP 367 EP 371 DI 10.1002/ptr.2328 PG 5 WC Chemistry, Medicinal; Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA 281EZ UT WOS:000254481000016 PM 18167050 ER PT J AU Adam, M Erkan, AN Arslan, D Leblebici, B Ozluoglu, L Akman, MN AF Adam, Mehmet Erkan, Alper Nabi Arslan, Didem Leblebici, Berrin Ozluoglu, Levent Akman, M. Nafiz TI High-frequency sensorineural hearing loss in patients with ankylosing spondylitis: is it an extrarticuler feature of disease? SO RHEUMATOLOGY INTERNATIONAL LA English DT Article DE ankylosing spondylitis; sensorineural hearing loss; high frequency ID MIDDLE-EAR; DISORDERS; TINNITUS AB Objective The aim of this study was to investigate the ear involvement, especially at extended higher frequencies than those previously studied, in patients with ankylosing spondylitis (AS). Patients and methods We prospectively evaluated 45 consecutive patients with AS. All patients underwent a complete physical examination of the ear, nose, and throat and an audiologic evaluation that included pure-tone audiometry at conventional and extended high frequencies, the determination of a speech discrimination score and the uncomfortable loudness level, and impedance audiometry. Thirty healthy volunteers were included as controls. Results The mean age of the patients was 39.6 +/- 9.1 years (range 19-63 years) and that of the controls was 10.6 +/- 8.1 years (range 1-30 years). There was no statistically significant difference between the two groups with respect to conventional frequency air conduction threshold and bone conduction threshold. There was a statistically significant difference at 14,000-16,000 Hz at extended high frequencies in 32 patients with AS (71.1%) versus 12 controls (40%). At 14,000-16,000 Hz, eight patients demonstrated a sensorineural hearing loss caused by extraspinal involvement. There was a significant difference between the patients with or without extraspinal involvement, and a positive correlation was noted between the duration of disease and the hearing level at 10,000-16,000 Hz. Conclusion Sensorineural hearing loss, especially at extended high frequencies, is common in patients with AS and may be an extra-articular feature of that disease. A long duration of disease and extraspinal involvement are important parameters for ear involvement in patients with AS. C1 [Adam, Mehmet; Leblebici, Berrin; Akman, M. Nafiz] Baskent Univ, Fac Med, Dept Phys Med & Rehabil, TR-01250 Adana, Turkey. [Erkan, Alper Nabi; Ozluoglu, Levent] Baskent Univ, Fac Med, Dept Otorhinolaryngol, TR-06490 Ankara, Turkey. [Arslan, Didem] Baskent Univ, Fac Med, Dept Rheumatol, TR-06490 Ankara, Turkey. RP Adam, M (reprint author), Baskent Univ, Fac Med, Dept Phys Med & Rehabil, Dadaloglu Mah,39 Sok,6, TR-01250 Adana, Turkey. 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Int. PD MAR PY 2008 VL 28 IS 5 BP 413 EP 417 DI 10.1007/s00296-007-0458-7 PG 5 WC Rheumatology SC Rheumatology GA 263FX UT WOS:000253204100003 PM 17899090 ER PT J AU Schaller, BJ Rasper, J Filis, A Buchfelder, M AF Schaller, B. J. Rasper, J. Filis, A. Buchfelder, M. TI Difference in functional outcome of ipsilateral tinnitus after intraoperative occurence of the trigemino-cardiac reflex in surgery for vestibular schwannomas SO ACTA NEUROCHIRURGICA LA English DT Article DE trigemino-cardiac reflex; tinnitus; hearing preserveration; vestibular schwannoma ID CEREBELLOPONTINE ANGLE; ACOUSTIC NEUROMA AB Object. Surgical manipulation of the fifth cranial nerve in its intra- or extracranial course may lead to bradycardia or even asystole as well as arterial hypotension, a phenomenon described as the trigemino-cardiac reflex (TCR), first described by the authors previonsly [11]. The authors report here the impact of this reflex on post-operative ipsilateral tinnitus in patients undergoing vestibular schwannoma surgery. Methods. Thirty six patients scheduled for vestibular schwannoma surgery were studied retrospectively for parameters influencing the post-operative ipsilateral tinnitus function. According to the occurrence of intra- operative TCR the patients were divided into a TCR-subgroup and a non-TCR subgroup. There was no difference in tumour size between these subgroups. Results. The TCR occured in 17% of the patients during vestibular schwannoma surgery and influenced the occurrence of post-operative ipsilateral tinnitus: the overall incidence of post-operative ipsilateral tinnitus was 22%. Sixty (60) percent of the patients in the TCR subgroup and 17% of those in the non-TCR subgroup expierenced ipsilateral tinnitus postoperatively. There was no correlation between tinnitus and pre- or post-operative hearing function. Conclusion. Hypotension after intra-operative TCR is not only a negative prognostic factor for hearing preservation but also for ipsilateral tinnitus in patients undergoing vestibular schwannoma surgery. In combination with worse hearing function after intra-operative TCR, the present finding underlines the importance of the TCR during skull base surgery in relation to improved functional outcome. C1 Univ Paris, Dept Neurosurg, F-75252 Paris, France. [Rasper, J.; Filis, A.; Buchfelder, M.] Univ Hosp, Dept Neurosurg, Erlangen, Germany. RP Schaller, BJ (reprint author), Univ Paris, Dept Neurosurg, F-75252 Paris, France. EM skull_base_surgery@yahoo.de CR Ferguson MA, 2001, EAR HEARING, V22, P173, DOI 10.1097/00003446-200106000-00001 GARDNER G, 1988, ANN OTO RHINOL LARYN, V97, P55 Gharabaghi A, 2006, J NEUROSURG, V104, P369, DOI 10.3171/jns.2006.104.3.369 PFALTZ CR, 1992, ACOUSTIC NEUROMA, P423 PRASHER DK, 1995, ACTA OTO-LARYNGOL, V115, P375, DOI 10.3109/00016489509139332 QUARANTA A, 1999, ACOUSTIC NEURINOMA O, P43 Sahley TL, 1997, EFFERENT AUDITORY SY Schaller B, 1999, J NEUROSURG, V90, P215, DOI 10.3171/jns.1999.90.2.0215 Schaller B, 2004, J NEUROL, V251, P658, DOI 10.1007/s00415-004-0458-4 Schaller BJ, 2007, BRAIN RES, V1149, P69, DOI 10.1016/j.brainres.2005.08.060 Schaller BJ, 2007, J NEUROSURG, V107, P243, DOI 10.3171/JNS-07/07/0243 Schuknecht HF, 1993, PATHOLOGY EAR NR 12 TC 12 Z9 12 PU SPRINGER WIEN PI WIEN PA SACHSENPLATZ 4-6, PO BOX 89, A-1201 WIEN, AUSTRIA SN 0001-6268 J9 ACTA NEUROCHIR JI Acta Neurochir. PD FEB PY 2008 VL 150 IS 2 BP 157 EP 160 DI 10.1007/s00701-007-1476-7 PG 4 WC Clinical Neurology; Surgery SC Neurosciences & Neurology; Surgery GA 259WY UT WOS:000252972800012 PM 18080085 ER PT J AU Poreisz, C Lang, N Paulus, W AF Poreisz, C. Lang, N. Paulus, W. TI Experimental treatment of chronic tinnitus: New therapeutic indications for repetitive magnetic stimulation? SO AKTUELLE NEUROLOGIE LA German DT Review DE rTMS; tinnitus; neuronavigation ID HUMAN MOTOR CORTEX; PARKINSONS-DISEASE; AUDITORY-CORTEX; CORTICOSPINAL EXCITABILITY; CORTICAL PLASTICITY; DOUBLE-BLIND; DEPRESSION; RTMS; TMS; EFFICACY AB Modulation of cortical excitability by means of transcranial stimulation has developed as a focus in neurophysiological research. Transcranial magnetic stimulation (TMS) is a useful tool to examine and influence neuronal processes in the intact human brain. Cortical excitability changes as well as imbalances of excitatory and inhibitory influences play a distinct role in the pathophysiology of some neuropsychiatric diseases such as chronic tinnitus. This work reviews studies that have attempted to influence the sensation of tinnitus using repetitive magnetic stimulation (rTMS). C1 [Poreisz, C.; Lang, N.; Paulus, W.] Univ Gottingen, Abt Klin Neurophysiol, D-37077 Gottingen, Germany. [Lang, N.] Univ Kiel, Neurol Klin, D-2300 Kiel, Germany. RP Poreisz, C (reprint author), Univ Gottingen, Abt Klin Neurophysiol, Robert Koch Str 40, D-37077 Gottingen, Germany. 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PD FEB PY 2008 VL 35 IS 1 BP 28 EP 33 DI 10.1055/s-2007-986222 PG 6 GA 277CM UT WOS:000254190300005 ER PT J AU Chadha, NK Weiner, GM AF Chadha, N. K. Weiner, G. M. TI Vascular loops causing otological symptoms: a systematic review and meta-analysis SO CLINICAL OTOLARYNGOLOGY LA English DT Review ID INFERIOR CEREBELLAR ARTERY; MICROVASCULAR COMPRESSION; CEREBELLOPONTINE ANGLE; DECOMPRESSION SURGERY; PULSATILE TINNITUS; HEARING-LOSS; NERVE AB Objective of review: To determine evidence for a relationship between vascular loops in contact with the vestibulocochlear nerve (CN VIII) and otological symptoms. Type of review: Systematic review and meta-analysis of observational studies. Search strategy: Comprehensive search of MEDLINE, EMBASE, CINAHL, Cochrane Library, Clinical Evidence and Cochrane Central Register of Trials. Reference lists cross-referenced and authors contacted for missing data. No language restrictions. Evaluation methods: Included studies: (1) compared symptoms in subjects with a vascular loop contacting CN VIII to subjects without (inter-subject control); (2) compared the prevalence of vascular loop in contact with CN VIII in symptomatic ears to contra-lateral asymptomatic ears (intra-subject control). Study quality systematically appraised. Results: Five case-control studies included. A statistically significant association was demonstrated for the prevalence of vascular loops in contact with CN VIII, with unilateral sensorineural hearing loss: pooled odds ratio (OR) 2.0 [95% confidence interval (CI): 1.5-2.6]. No association was demonstrated for non-pulsatile tinnitus. A highly significant association with vascular loops was shown in subjects having pulsatile tinnitus, with pooled OR: 78.8 (95% CI: 10.9-821.8). Conclusions: Vascular loops in contact with CN VIII are a normal variant. Subjects with unilateral hearing loss were twice as likely to have these vascular loops in the symptomatic ear, than in the asymptomatic ear. Subjects with pulsatile tinnitus were 80 times more likely to have a contacting vascular loop than patients with non-pulsatile tinnitus, suggesting in some cases a causal relationship exists for pulsatile tinnitus, where surgical intervention may be occasionally indicated. C1 [Chadha, N. K.; Weiner, G. M.] Royal Devon & Exeter Hosp, Dept ENT, Exeter EX2 5DW, Devon, England. RP Chadha, NK (reprint author), Royal Devon & Exeter Hosp, Dept ENT, Barrack Rd, Exeter EX2 5DW, Devon, England. 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PD FEB PY 2008 VL 33 IS 1 BP 5 EP 11 DI 10.1111/j.1749-4486.2007.01597.x PG 7 WC Otorhinolaryngology SC Otorhinolaryngology GA 267KD UT WOS:000253507000002 PM 18302544 ER PT J AU Lloyd, SKW Baguley, DM AF Lloyd, S. K. W. Baguley, D. M. TI A patient with tinnitus SO CLINICAL OTOLARYNGOLOGY LA English DT Article C1 [Lloyd, S. K. W.; Baguley, D. M.] Addenbrookes Hosp, Dept Otolaryngol, Cambridge CB2 2QQ, England. RP Lloyd, SKW (reprint author), Addenbrookes Hosp, Dept Otolaryngol, Cambridge CB2 2QQ, England. 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Otolaryngol. PD FEB PY 2008 VL 33 IS 1 BP 25 EP 28 DI 10.1111/j.1749-4486.2007.01599.x PG 4 WC Otorhinolaryngology SC Otorhinolaryngology GA 267KD UT WOS:000253507000005 PM 18302547 ER PT J AU Leonetti, JP Shirazi, MA Marzo, S Anderson, D AF Leonetti, John P. Shirazi, Mobeen A. Marzo, Sam Anderson, Douglas TI Neuroendocrine carcinoma of the jugular foramen SO ENT-EAR NOSE & THROAT JOURNAL LA English DT Article ID CANCER; MANAGEMENT; LARYNX; TUMORS; CELLS; KI-67; HEAD; NECK; BONE AB We describe what might have been the first reported case Of a neuroendocrine carcinoma of the jugular foramen. A 50-year-old woman presented with progressive left-sided sensorineural hearing loss, vertigo, pulsatile tinnitus, headaches, and ataxia. Magnetic resonance imaging revealed a 4-cm left-sided jugular foramen tumor. The patient underwent near-total resection of the tumor. Despite lower cranial nerve preservation, postoperative paralysis of cranial nerves IX and X occurred, and vocal fold medialization was performed 5 days later. The final pathologic diagnosis was neuroendocrine carcinoma. The patient was treated with concurrent chemotherapy and intensity-modulated radiation therapy. This article will discuss the pathologic features and the management of jugular foramen tumors, along with the differential diagnosis of these rare tumors. C1 [Leonetti, John P.; Shirazi, Mobeen A.; Marzo, Sam] Skull Base Surg Ctr, Dept Otolaryngol Head & Neck Surg, Maywood, IL 60153 USA. [Anderson, Douglas] Loyola Univ, Med Ctr, Dept Neurosurg, Maywood, IL USA. RP Leonetti, JP (reprint author), Skull Base Surg Ctr, Dept Otolaryngol Head & Neck Surg, 2160 S First Ave, Bldg 105, Rm 1870, Maywood, IL 60153 USA. 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PD FEB PY 2008 VL 87 IS 2 BP 86 EP + PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA 266NO UT WOS:000253443200009 PM 18437928 ER PT J AU Zehlicke, T Punke, C Dressler, D Pau, HW AF Zehlicke, Thorsten Punke, Christoph Dressler, Dirk Pau, Hans Wilhelm TI Intratympanic application of botulinum toxin: experiments in guinea pigs for excluding ototoxic effects SO EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY LA English DT Article DE m. tensor tympani; tenotomy; botulinum toxin; ototoxicity; ABR measurements ID MIDDLE-EAR MYOCLONUS; SYMPTOMS; TINNITUS; RHINITIS AB The aim of the study was to exclude ototoxic side effects of intratympanally applied botulinum toxin. The background is that a transection of the tensor tympani tendon (tenotomy) may relieve symptoms of tinnitus due to myoclonic tensor contractions. Moreover, there are certain indications that in some cases tenotomy may influence the course of Meniere's disease positively. In such cases, a temporary (probatory) inactivation of the muscle with botulinum toxin might be better than a definitive surgical solution. Although in theory botulinum toxin should not have ototoxic side effects, a study on animals (guinea pigs) should prove this assumption. On eight guinea pigs (16 ears), the middle ear spaces (bullae) were opened and botulinum toxin was introduced. Hearing thresholds were measured via ABR recordings, prior to 1 and 3 weeks, respectively, after botulinum toxin application. Histological examinations of the middle ear mucosa were performed on each animal. In our series, the hearing thresholds remained essentially unchanged. Furthermore, no middle ear pathologies could be found in histology. No negative effects of botulinum toxin on hearing could be observed in our series. This is a precondition for the further development of the concept of intratympanical applications of the drug, to inactivate the tensor tympani muscle or for other options. C1 [Zehlicke, Thorsten; Punke, Christoph; Pau, Hans Wilhelm] Univ Rostock, Dept Otorhinolaryngol Head & Neck Surg Otto Koern, D-18057 Rostock, Germany. [Dressler, Dirk] Univ Rostock, Dept Neurol, D-18057 Rostock, Germany. RP Zehlicke, T (reprint author), Univ Rostock, Dept Otorhinolaryngol Head & Neck Surg Otto Koern, Doberaner Str 137-139, D-18057 Rostock, Germany. 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Arch. Oto-Rhino-Laryn. PD FEB PY 2008 VL 265 IS 2 BP 167 EP 170 DI 10.1007/s00405-007-0432-8 PG 4 WC Otorhinolaryngology SC Otorhinolaryngology GA 257KT UT WOS:000252798700005 PM 17763835 ER PT J AU Langguth, B Kleinjung, T Frank, E Landgrebe, M Sand, P Dvorakova, J Frick, U Eichhammer, P Hajak, G AF Langguth, Berthold Kleinjung, Tobias Frank, Elmar Landgrebe, Michael Sand, Philipp Dvorakova, Jana Frick, Ulrich Eichhammer, Peter Hajak, Goeran TI High-frequency priming stimulation does not enhance the effect of low-frequency rTMS in the treatment of tinnitus SO EXPERIMENTAL BRAIN RESEARCH LA English DT Article DE long term depression; neuroplasticity; repetitive transcranial magnetic stimulation; tinnitus; hyperexcitability disorder ID TRANSCRANIAL MAGNETIC STIMULATION; POSITRON-EMISSION-TOMOGRAPHY; RESISTANT AUDITORY HALLUCINATIONS; CEREBRAL-BLOOD-FLOW; MOTOR CORTEX; SYNAPTIC PLASTICITY; DEPRESSED-PATIENTS; EFFICACY; BRAIN AB Based on its ability to reduce the excitability of the cortex locally, low-frequency repetitive transcranial magnetic stimulation (rTMS) has been investigated for the treatment of hyperexcitability disorders such as auditory hallucinations and tinnitus. Results are promising, but characterized by only moderate improvement and a high inter-individual variability. Experimental data from motor cortex stimulation in healthy subjects indicates that the depressant effect of low-frequency rTMS can be enhanced by high-frequency priming stimulation. Here we will investigate whether high-frequency priming also improves the therapeutic efficacy of low-frequency rTMS in a clinical application. 32 patients with chronic tinnitus were randomly assigned to either a standard protocol of low-frequency rTMS (110% motor threshold, 1 Hz, 2000 stimuli/day) or a stimulation protocol in which priming stimulation with 6 Hz (90% motor threshold, 960 stimuli) preceded low-frequency rTMS (110% motor threshold, 1 Hz, 1040 stimuli/day). Stimulation was applied over the left auditory cortex by using MRI-guided coil positioning. The treatment outcome was assessed with a standardized tinnitus questionnaire. There was no significant difference between the standard protocol and the protocol involving priming stimulation. Both stimulation protocols resulted in significant clinical improvement after 10 days of stimulation, as compared to baseline. Our data does not support an enhancing effect of higher frequency priming on low-frequency rTMS in the treatment of tinnitus. C1 [Langguth, Berthold; Frank, Elmar; Landgrebe, Michael; Sand, Philipp; Dvorakova, Jana; Eichhammer, Peter; Hajak, Goeran] Univ Regensburg, Dept Psychiat Psychotherapy & Psychosomat, D-93053 Regensburg, Germany. [Kleinjung, Tobias] Univ Regensburg, Dept Otorhinolaryngol & Audiol, D-93053 Regensburg, Germany. [Dvorakova, Jana] Charles Univ Prague, Dept Psychiat, Prague, Czech Republic. [Frick, Ulrich] Carinthia Univ Appl Sci, Dept Healthcare Management, Spittal, Austria. RP Langguth, B (reprint author), Univ Regensburg, Dept Psychiat Psychotherapy & Psychosomat, Univ Str 84, D-93053 Regensburg, Germany. 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Brain Res. PD FEB PY 2008 VL 184 IS 4 BP 587 EP 591 DI 10.1007/s00221-007-1228-1 PG 5 WC Neurosciences SC Neurosciences & Neurology GA 253TL UT WOS:000252540400013 PM 18066684 ER PT J AU Atmane, M El Kharras, A Boumedin, H Mahi, M Chaouir, S Jidal, M Benameur, M Bassou, D AF Atmane, M. El Kharras, A. Boumedin, H. Mahi, M. Chaouir, S. Jidal, M. Benameur, M. Bassou, D. TI Tympanic paraganglioma: imaging findings in a case report SO FEUILLETS DE RADIOLOGIE LA French DT Article DE ear; tumor ID CAROTID-BODY TUMORS; GLOMUS TUMORS AB Glomus tumors are rare and a tympanic localization is exceptional. We report the case of a patient followed for conductive hearing loss and pulsatile tinnitus. The imaging study and histopathology were in favor of a tympanic paraganglioma. C1 [Atmane, M.; El Kharras, A.; Boumedin, H.; Mahi, M.; Chaouir, S.; Jidal, M.; Benameur, M.; Bassou, D.] Hop Mil Instruct Mohamed V, Serv Imagerie Med, Rabat, Morocco. 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PD FEB PY 2008 VL 48 IS 1 BP 15 EP 18 DI 10.1016/S0181-9801(08)70314-2 PG 4 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA 314FK UT WOS:000256794700003 ER PT J AU Wang, HT Luo, B Huang, YN Zhou, KQ Chen, L AF Wang, Hai-Tao Luo, Bin Huang, Yi-Na Zhou, Ke-Qing Chen, Lin TI Sodium salicylate suppresses serotonin-induced enhancement of GABAergic spontaneous inhibitory postsynaptic currents in rat inferior colliculus in vitro SO HEARING RESEARCH LA English DT Article DE serotonin; GABAergic spontaneous inhibitory postsynaptic current; tinnitus; sodium salicylate; brain slice; inferior colliculus ID PREFRONTAL CORTEX; AUDITORY-CORTEX; CEREBRAL-CORTEX; INDUCED TINNITUS; 5-HT3 RECEPTORS; NEURAL ACTIVITY; ANIMAL-MODEL; NEURONS; INTERNEURONS; GABA AB Available evidence suggests that sodium salicylate (SS) may produce tinnitus through altering the balance between inhibition and excitation in the central auditory system. Since serotonin (5-hydroxytryptamine, 5-HT) containing fibers preferentially innervate inhibitory GABA neurons, there exists a possibility that SS causes the imbalance between inhibition and excitation through influencing serotonergic modulation of the GABAergic synaptic transmission. In the present study, we examined the effects of SS on 5-HT-mediated GABAergic spontaneous inhibitory postsynaptic currents (sIPSCs) from neurons of the central nucleus of rat inferior colliculus with whole-cell patch-clamp technique and brain slice preparation. Perfusion of 40 mu M 5-HT robustly enhanced both frequency and amplitude of GABAergic sIPSCs and this 5-HT-induced enhancement of GABAergic sIPSCs could be suppressed by 1.4 mM SS. Tetrodotoxin at 0.5 mu M produced a similar effect as SS did, suggesting that SS suppresses the 5-HT-induced enhancement of GABAergic sIPSCs through depressing spontaneous action potentials of GABA neurons. Our findings suggest that SS may preferentially target GABA neurons and consequently interrupt a normal level of GABAergic synaptic transmissions maintained by the serotonergic system in SS-induced tinnitus. (c) 2007 Elsevier B.V. All rights reserved. C1 [Wang, Hai-Tao; Luo, Bin; Huang, Yi-Na; Chen, Lin] Univ Sci & Technol China, Sch Life Sci, Auditory Res Lab, Hefei 230027, Peoples R China. [Wang, Hai-Tao; Luo, Bin; Huang, Yi-Na; Chen, Lin] Univ Sci & Technol China, Hefei Nat Lab Phys Sci Microscale, Hefei 230027, Peoples R China. [Zhou, Ke-Qing] Univ Sci & Technol China, Lab Receptor Pharmacol, Hefei 230027, Peoples R China. RP Chen, L (reprint author), Univ Sci & Technol China, Sch Life Sci, Auditory Res Lab, Hefei 230027, Peoples R China. 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Res. PD FEB PY 2008 VL 236 IS 1-2 BP 42 EP 51 DI 10.1016/j.heares.2007.11.015 PG 10 WC Audiology & Speech-Language Pathology; Neurosciences; Otorhinolaryngology SC Audiology & Speech-Language Pathology; Neurosciences & Neurology; Otorhinolaryngology GA 277WL UT WOS:000254245300005 PM 18222054 ER PT J AU Strauss, DJ Delb, W D'Amelio, R Low, YF Falkai, P AF Strauss, Daniel J. Delb, Wolfgang D'Amelio, Roberto Low, Yin Fen Falkai, Peter TI Objective quantification of the tinnitus decompensation by synchronization measures of auditory evoked single sweeps SO IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING LA English DT Article DE adaptive resonance theory; attention; auditory evoked responses; synchronization stability; tinnitus; top-down processes; wavelets ID SELECTIVE-ATTENTION; MODEL; CORTEX; REORGANIZATION; PERCEPTION; DISTRESS AB Large-scale neural correlates of the tinnitus decompensation might be used for an objective evaluation of therapies and neurofeedback based therapeutic approaches. In this study, we try to identify large-scale neural correlates of the tinnitus decompensation using wavelet phase stability criteria of single sweep sequences of late auditory evoked potentials as synchronization stability measure. The extracted measure provided an objective quantification of the tinnitus decompensation and allowed for a reliable discrimination between a group of compensated and decompensated tinnitus patients. We provide an interpretation for our results by a neural model of top-down projections based on the Jastreboff tinnitus model combined with the adaptive resonance theory which has not been applied to model tinnitus so far. Using this model, our stability measure of evoked potentials can be linked to the focus of attention on the tinnitus signal. It is concluded that the wavelet phase stability of late auditory evoked potential single sweeps might be used as objective tinnitus decompensation measure and can be interpreted in the framework of the Jastreboff tinnitus model and adaptive resonance theory. C1 [Strauss, Daniel J.; Delb, Wolfgang; Low, Yin Fen] Univ Saarland, Computat Diagnost & Biocybernet Unit, D-66421 Homburg, Germany. 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PD FEB PY 2008 VL 16 IS 1 BP 74 EP 81 DI 10.1109/TNSRE.2007.911086 PG 8 WC Engineering, Biomedical; Rehabilitation SC Engineering; Rehabilitation GA 266NH UT WOS:000253442400010 PM 18303808 ER PT J AU Kang, KT Young, YH AF Kang, K-T Young, Y-H TI Sudden sensorineural hearing loss in a patient wit primary antiphospholipid syndrome SO JOURNAL OF LARYNGOLOGY AND OTOLOGY LA English DT Article DE Antiphospholipid syndrome; sensorineurall deafness; warfarin ID LUPUS-ERYTHEMATOSUS; ASSOCIATION; ANTIBODIES; DISORDERS AB Objective: Despite multiple systemic manifestations, sudden sensorineural hearing loss in a patient with antiphospholipid syndrome is rarely reported. Patient: A 46-year-old man with primary antiphospholipid syndrome had a sudden onset of hearing loss and tinnitus in the right ear in December 2005, because he discontinued use of warfarin and acetylsalicylic acid for a few days. Results: Audiometry revealed saucer-type sensorineural hearing loss with a pure tone average of 73 dB in the right ear, and flat-type hearing loss with a pure tone average of 25 dB in the left ear. Electronystagmography displayed multiple central signs and bilateral canal paresis, while a vestibular evoked myogenic potential test revealed bilateral delayed responses. After admission, the patient was re-treated with warfarin and acetylsalicylic acid. Follow-up audiometry showed recovery of right-sided hearing, with a pure tone average of 12 dB, three days after presentation. Conclusion: Consensus exists on the effectiveness of anticoagulant agents in adding a favourable outcome of sudden sensorineural hearing loss in patients with antiphospholipid syndrome. C1 [Kang, K-T; Young, Y-H] Natl Taiwan Univ, Natl Taiwan Univ Hosp, Coll Med, Dept Otolaryngol, Taipei 10764, Taiwan. RP Kang, KT (reprint author), Natl Taiwan Univ, Natl Taiwan Univ Hosp, Coll Med, Dept Otolaryngol, Taipei 10764, Taiwan. CR Bachor E, 2005, EUR ARCH OTO-RHINO-L, V262, P622, DOI 10.1007/s00405-004-0877-y Behbehani Raed, 2004, Curr Opin Ophthalmol, V15, P483, DOI 10.1097/01.icu.0000144389.97491.52 Bir LS, 2006, J THROMB THROMBOLYS, V21, P277, DOI 10.1007/s11239-006-6156-6 Chen CH, 2003, LARYNGOSCOPE, V113, P990, DOI 10.1097/00005537-200306000-00014 Compadretti GC, 2005, ANN OTO RHINOL LARYN, V114, P214 de Groot PG, 2005, CURR OPIN INFECT DIS, V18, P205, DOI 10.1097/01.qco.0000168379.01272.53 DiGiovanni JJ, 2006, J AM ACAD AUDIOL, V17, P498, DOI 10.3766/jaaa.17.7.5 Galli M, 2003, SEMIN THROMB HEMOST, V29, P195, DOI 10.1055/s-2003-38835 Green L, 2001, CLIN RHEUMATOL, V20, P220, DOI 10.1007/s100670170069 Khamashta MA, 2004, AUTOIMMUNITY, V37, P309, DOI 10.1080/08916930410001708706 Marai I, 2004, SCAND J RHEUMATOL, V33, P365, DOI 10.1080/03009740410010290 Mouadeb DA, 2005, LARYNGOSCOPE, V115, P879, DOI 10.1097/01.MLG.0000158666.15447.37 Noguchi Y, 2000, AUDIOLOGY, V39, P19 Sammaritano LR, 2005, SOUTH MED J, V98, P617, DOI 10.1097/01.smj.0000166748.90089.65 Toubi E, 2004, ANN OTO RHINOL LARYN, V113, P445 Wilson WA, 1999, ARTHRITIS RHEUM, V42, P1309, DOI 10.1002/1529-0131(199907)42:7<1309::AID-ANR1>3.0.CO;2-F Wong M, 2005, RHEUMATOLOGY, V44, P948, DOI 10.1093/rheumatology/keh645 NR 17 TC 2 Z9 2 PU CAMBRIDGE UNIV PRESS PI CAMBRIDGE PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND SN 0022-2151 J9 J LARYNGOL OTOL JI J. Laryngol. Otol. PD FEB PY 2008 VL 122 IS 2 BP 204 EP 206 DI 10.1017/S0022215107007736 PG 3 WC Otorhinolaryngology SC Otorhinolaryngology GA 266KV UT WOS:000253435000019 PM 17419896 ER PT J AU Pothier, DD Bredenkamp, CL AF Pothier, D. D. Bredenkamp, C-L TI The placebo effect of transcutaneous electrical nerve stimulation SO JOURNAL OF LARYNGOLOGY AND OTOLOGY LA English DT Letter ID TINNITUS C1 [Pothier, D. D.; Bredenkamp, C-L] Royal United Hosp, Bath BA1 3NG, Avon, England. RP Pothier, DD (reprint author), Royal United Hosp, Bath BA1 3NG, Avon, England. CR Aydemir G, 2006, J LARYNGOL OTOL, V120, P442, DOI 10.1017/S0022215106000910 Brosseau L, 2002, SPINE, V27, P596, DOI 10.1097/00007632-200203150-00007 CONN IG, 1986, ANN ROY COLL SURG, V68, P191 DOBIE RA, 1986, OTOLARYNG HEAD NECK, V95, P319 THEDINGER BS, 1987, LARYNGOSCOPE, V97, P33 NR 5 TC 0 Z9 0 PU CAMBRIDGE UNIV PRESS PI CAMBRIDGE PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND SN 0022-2151 J9 J LARYNGOL OTOL JI J. Laryngol. Otol. PD FEB PY 2008 VL 122 IS 2 BP 217 EP 217 PG 1 WC Otorhinolaryngology SC Otorhinolaryngology GA 266KV UT WOS:000253435000023 PM 18252020 ER PT J AU Tezer, MS AF Tezer, M. S. TI The placebo effect of transcutaneous electrical nerve stimulation - Reply SO JOURNAL OF LARYNGOLOGY AND OTOLOGY LA English DT Letter ID TINNITUS C1 [Tezer, M. S.] Ankara Numune Training & Res Hosp, Dept Otorhinolaryngol, Ankara, Turkey. RP Tezer, MS (reprint author), Ankara Numune Training & Res Hosp, Dept Otorhinolaryngol, Ankara, Turkey. CR CAZALS Y, 1978, J AM AUDITORY SOC, V3, P209 CHOUARD CH, 1981, ACTA OTO-LARYNGOL, V91, P415, DOI 10.3109/00016488109138522 ENGELBERG M, 1985, LARYNGOSCOPE, V95, P1167 Steenerson RL, 1999, OTOLARYNG HEAD NECK, V121, P511, DOI 10.1016/S0194-5998(99)70048-3 NR 4 TC 0 Z9 0 PU CAMBRIDGE UNIV PRESS PI CAMBRIDGE PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND SN 0022-2151 J9 J LARYNGOL OTOL JI J. Laryngol. Otol. PD FEB PY 2008 VL 122 IS 2 BP 217 EP 217 PG 1 WC Otorhinolaryngology SC Otorhinolaryngology GA 266KV UT WOS:000253435000024 ER PT J AU Khedr, EM Rothwell, JC Ahmed, MA El-Atar, A AF Khedr, E. M. Rothwell, J. C. Ahmed, M. A. El-Atar, A. TI Effect of daily repetitive transcranial magnetic stimulation for treatment of tinnitus: comparison of different stimulus frequencies SO JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY LA English DT Article ID DOUBLE-BLIND; RTMS; SUPPRESSION; EFFICACY AB We compared the effect of different frequencies of repetitive transcranial magnetic stimulation (rTMS) (1 Hz, 10 Hz, 25 Hz and sham (occipital, 1 Hz)), given daily over the left temporoparietal cortex for 2 weeks, on 66 patients with chronic tinnitus randomly divided into four treatment groups. Patients were assessed using the Tinnitus Handicap Inventory, self- ratings of symptoms and audiometric measures of residual inhibition before, immediately after 2 weeks' treatment and monthly thereafter for 4 consecutive months. Results: There were no significant differences in basal measures between the four groups of patients. A two-factor ANOVA revealed a significant "rTMS'' x "time'' interaction for all measures. This was because real rTMS produced greater improvement than sham. However, there was no significant difference between the responses to different frequencies of rTMS. The response to rTMS depended on the duration of tinnitus: patients who had tinnitus for the longest period of time were the least likely to respond to treatment. Conclusion: Daily sessions of rTMS over the temporoparietal cortex may be a useful potential treatment for tinnitus. C1 [Khedr, E. M.; Ahmed, M. A.] Assiut Univ Hosp, Dept Neurol, Assiut 71511, Egypt. [Rothwell, J. C.] UCL Natl Hosp Neurol & Neurosurg, Sobell Res Dept Motor Neurosci & Movement Disorde, London WC1N 3BG, England. [El-Atar, A.] Assiut Univ Hosp, Dept Audiol, Assiut, Egypt. RP Khedr, EM (reprint author), Assiut Univ Hosp, Dept Neurol, Assiut 71511, Egypt. EM emankhedr99@yahoo.com CR Bahmad Fayez M Jr, 2006, Int Tinnitus J, V12, P140 De Ridder D, 2005, OTOL NEUROTOL, V26, P616, DOI 10.1097/01.mao.0000178146.91139.3c De Ridder D, 2006, ORL J OTO-RHINO-LARY, V68, P48, DOI 10.1159/000090491 Eichhammer P, 2003, BIOL PSYCHIAT, V54, P862, DOI 10.1016/S0006-3223(03)01896-6 FREGNI F, 2000, J AM ACAD AUDIOL, V11, P125 Khedr EM, 2005, J NEUROL NEUROSUR PS, V76, P833, DOI 10.1136/jnnp.2004.055806 Khedr EM, 2006, MOVEMENT DISORD, V21, P2201, DOI 10.1002/mds.21089 Kleinjung T, 2005, OTOLARYNG HEAD NECK, V132, P566, DOI 10.1016/j.otohns.2004.09.134 Kroner-Herwig B, 2003, J PSYCHOSOM RES, V54, P381, DOI 10.1016/S0022-3999(02)00400-2 Langguth B, 2006, BRAIN TOPOGR, V18, P241, DOI 10.1007/s10548-006-0002-1 Langguth B, 2003, NEUROREPORT, V14, P977, DOI 10.1097/01.wnr.0000068897.39523.41 Moller A R, 2000, J Am Acad Audiol, V11, P115 Newman CW, 1996, ARCH OTOLARYNGOL, V122, P143 Plewnia C, 2003, ANN NEUROL, V53, P263, DOI 10.1002/ana.10468 Plewnia C, 2007, J NEUROL NEUROSUR PS, V78, P152, DOI 10.1136/jnnp.2006.095612 Plewnia C, 2007, HUM BRAIN MAPP, V28, P238, DOI 10.1002/hbm.20270 ROBERTS LE, 2006, ACTA OTO-LARYNGOL, V556, P27, DOI DOI 10.1080/03655230600895358 Rossi S, 2007, J NEUROL NEUROSUR PS, V78, P857, DOI 10.1136/jnnp.2006.105007 Touge T, 2001, CLIN NEUROPHYSIOL, V112, P2138, DOI 10.1016/S1388-2457(01)00651-4 Zoger S, 2006, J CLIN PSYCHOPHARM, V26, P32, DOI 10.1097/01.jcp.0000195111.86650.19 NR 20 TC 71 Z9 73 PU B M J PUBLISHING GROUP PI LONDON PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND SN 0022-3050 J9 J NEUROL NEUROSUR PS JI J. Neurol. Neurosurg. Psychiatry PD FEB PY 2008 VL 79 IS 2 AR 212 DI 10.1136/jnnp.2007.127712 PG 4 WC Clinical Neurology; Psychiatry; Surgery SC Neurosciences & Neurology; Psychiatry; Surgery GA 261PG UT WOS:000253091900029 PM 18202212 ER PT J AU Muluk, NB Oguzturk, O AF Muluk, Nuray Bayar Oguzturk, Omer TI Occupational Noise-Induced Tinnitus: Does It Affect Workers' Quality of Life? SO JOURNAL OF OTOLARYNGOLOGY-HEAD & NECK SURGERY LA English DT Article DE maximum exposed noise; mean noise per hour; occupational noise-induced tinnitus; quality of life; SF-36 Health Survey; tinnitus loudness levels; total noise exposure time AB Objectives: This prospective study aimed to investigate the quality of life of workers in a steel factory. Methods: The study group was composed of 16 male workers with tinnitus and 30 ears. Fifteen male workers without tinnitus and 30 ears were included into the control group. Workers were evaluated by questionnaire, pure-tone audiometry, and the SF-36 Health Survey. In the study group, tinnitus loudness levels (TLLs) were found. Results: In the study group, the domains general mental health and role limitations owing to emotional problems were significantly lower than in the control group. Older age, industrial noise exposure over a long period, higher noise exposure during work, and hearing loss secondary to occupational noise caused workers to experience higher TLLs. Earheadings protected workers more than earplugs, and TLLs were lower. Important factors that affect workers' quality of life are maximum exposed noise levels, daily and total noise exposure time, and exposure to continuous noise. Occupational noise-induced tinnitus mainly causes emotional disability rather than physical disability. Emotionally impaired QOL results may be due to tinnitus-related psychological problems. Conclusion: Workers should have knowledge about the hazardous effects of noise. Periodic health checkups and regular seminars have great importance. Workers must be aware of other ototoxic factors, such as medications and noisy music. In the future, researchers should develop a screening method to detect those with a more hereditary affinity to hearing loss. C1 [Muluk, Nuray Bayar] Kirikkale Univ, Fac Med, ENT Dept, Kirikkale, Turkey. [Oguzturk, Omer] Kirikkale Univ, Fac Med, Dept Psychiat, Kirikkale, Turkey. RP Muluk, NB (reprint author), Zirvekent 2,Etap Sitesi,C-3 Blok,62-43, TR-06610 Ankara, Turkey. EM nbayarmuluk@yahoo.com CR *AM TINN ASS, 1986, TINN PAT SURV Axelsson A, 2000, NOISE HEALTH, V2, P47 CUMMINGS CW, 1998, OTOLARYNGOLOGY HEAD, V4 Dias Adriano, 2006, Cad Saude Publica, V22, P63, DOI 10.1590/S0102-311X2006000100007 Eggermont JJ, 2004, TRENDS NEUROSCI, V27, P676, DOI 10.1016/j.tins.2004.08.010 Green DS, 1983, HDB CLIN AUDIOLOGY, P98 Kowalska Sylwia, 2001, Medycyna Pracy, V52, P305 MULUK N, 2007, J OTOLARYNG IN PRESS Muluk NB, 2006, J OTOLARYNGOL, V35, P320, DOI 10.2310/7070.2005.0117 Muly SM, 2004, J NEUROSCI RES, V75, P585, DOI 10.1002/jnr.20011 PAPARELLA MM, 1991, OTOLARYNGOLOGY, V2 ROLAND PS, INNER EAR NOISE INDU Sliwinska-Kowalska M, 2001, NOISE HEALTH, V3, P75 WARE JE, 1992, MED CARE, V30, P473, DOI 10.1097/00005650-199206000-00002 World Medical Association Declaration of Helsinki, 2000, JAMA-J AM MED ASSOC, V284, P3043, DOI DOI 10.1001/JAMA.284.23.3043 NR 15 TC 3 Z9 3 PU B C DECKER INC PI HAMILTON PA 50 KING STREET EAST, 2ND FLOOR, PO BOX 620, L C D 1, HAMILTON, ONTARIO L8N 3K7, CANADA SN 1916-0216 J9 J OTOLARYNGOL-HEAD N JI J. Otolaryngol-Head Neck Surg. PD FEB PY 2008 VL 37 IS 1 BP 65 EP 71 DI 10.2310/7070.2008.0008 PG 7 WC Otorhinolaryngology SC Otorhinolaryngology GA 410SQ UT WOS:000263599000016 PM 18479630 ER PT J AU Ritenour, AE Wickley, A Ritenour, JS Kriete, BR Blackbourne, LH Holcomb, JB Wade, CE AF Ritenour, Amber E. Wickley, Aaron Ritenour, Joshua S. Kriete, Brian R. Blackbourne, Lome H. Holcomb, John B. Wade, Charles E. TI Tympanic membrane perforation and hearing loss from blast overpressure in operation enduring freedom and operation Iraqi freedom wounded SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article DE blast; improvised explosive device; explosion; ears; hearing; tympanic membrane; OEF; OIF ID INJURY; EAR; MANAGEMENT; EXPLOSION; SYSTEM; SURVIVORS; BOMBINGS; GUIDE AB Background: Tympanic membrane perforation is the most common primary blast injury in the current conflicts and occurs in approximately one tenth of service members wounded by combat explosions. We wanted to determine the severity of perforation and its effect on hearing and combat readiness. Methods: This analysis is a retrospective study of US service members injured in combat explosions in Afghanistan or Iraq and treated at our institution between March 2003 and July 2006. Data captured included location and grade of perforation, symptoms, healing rates, andiogram results, need for hearing aids, and loss of eligibility for military service. Results: Of 436 explosion-wounded patients admitted to our facility, 65 (15%) patients had tympanic membrane perforation diagnosed by the otolaryngology service. A total of 97 tympanic membrane perforations occurred among 65 patients. The average surface area involved was 41% +/- 32% (right) and 35% +/- 34% (left). More than one third of perforations were grade 4. The most common locations were central and anterior-inferior. Most (83%) patients reported symptoms, most commonly diminished hearing (77%) and tinnitus (50%). Outcome data were available for 77% of perforations. Spontaneous healing occurred in 48%. The remainder (52%) had surgical intervention. The most common audiogram abnormality was mild high frequency hearing loss. Ultimately, three patients (5%) required hearing aids and one discharge from military service. Conclusions: Tympanic membrane perforation occurs in 16% of explosion-injured patients. Most patients are symptomatic and many have large perforations requiring operative intervention. Longterm hearing loss is uncommon but does impact ability to continue military service. C1 [Ritenour, Amber E.; Wickley, Aaron; Ritenour, Joshua S.; Kriete, Brian R.; Blackbourne, Lome H.; Holcomb, John B.; Wade, Charles E.] USA, Inst Surg Res, San Antonio, TX USA. RP Wade, CE (reprint author), USA, Inst Surg Res, San Antonio, TX USA. EM charles.wade@amedd.army.mil CR Almogy G, 2005, ARCH SURG-CHICAGO, V140, P390, DOI 10.1001/archsurg.140.4.390 Argyros GJ, 1997, TOXICOLOGY, V121, P105, DOI 10.1016/S0300-483X(97)03659-7 Bilski TR, 2003, J TRAUMA, V54, P814, DOI 10.1097/01.TA.0000046627.87250.1D Casler J D, 1989, Ann Otol Rhinol Laryngol Suppl, V140, P13 Chait R H, 1989, Ann Otol Rhinol Laryngol Suppl, V140, P9 Chambers LW, 2005, ARCH SURG-CHICAGO, V140, P26, DOI 10.1001/archsurg.140.1.26 GARTH RJN, 1995, INJURY, V26, P363, DOI 10.1016/0020-1383(95)00042-8 Gondusky JS, 2005, MIL MED, V170, P546 Helling ER, 2004, MIL MED, V169, P872 HIRSCH FG, 1968, ANN NY ACAD SCI, V152, P147, DOI 10.1111/j.1749-6632.1968.tb11972.x JAMES DJ, 1982, 0482 AWRECDE JONSSON A, 1990, C2080223 FAO KALB JT, 1989, ANN OTO RHINOL LARYN, V140, P42 KORKIS F B, 1952, J Laryngol Otol, V66, P95, DOI 10.1017/S0022215100047332 Kozuka M, 1997, CLIN OTOLARYNGOL, V22, P106, DOI 10.1046/j.1365-2273.1997.00863.x KRONENBERG J, 1988, AM J OTOL, V9, P127 KRONENBERG J, 1993, AM J OTOL, V14, P92 Leibovici D, 1996, J TRAUMA, V41, P1030, DOI 10.1097/00005373-199612000-00015 MELLOR SG, 1989, BRIT J SURG, V76, P1006, DOI 10.1002/bjs.1800761006 Mrena R, 2004, ACTA OTO-LARYNGOL, V124, P946, DOI 10.1080/00016480310017045 PAHOR AL, 1981, J LARYNGOL OTOL, V95, P399, DOI 10.1017/S0022215100090873 PATOW CA, 1994, OTOLARYNG HEAD NECK, V110, P211 Patterson JH, 1997, TOXICOLOGY, V121, P29, DOI 10.1016/S0300-483X(97)03653-6 Phillips Y Y, 1989, Ann Otol Rhinol Laryngol Suppl, V140, P3 Singh D, 1968, J Laryngol Otol, V82, P1017, DOI 10.1017/S0022215100069802 Strohm M, 1986, Adv Otorhinolaryngol, V35, P1 ZALEWSKI T, 1906, Z OHRENHEILKD, V52, P109 ZIV M, 1973, MIL MED, V138, P811 2004, EMERGENCY WAR SURG NR 29 TC 31 Z9 32 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD FEB PY 2008 VL 64 IS 2 SU S BP S174 EP S178 DI 10.1097/TA.0b013e318160773e PG 5 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 265UJ UT WOS:000253386200047 PM 18376162 ER PT J AU Cosetti, M Linstrom, C Alexiades, G Tessema, B Parisier, S AF Cosetti, Maura Linstrom, Christopher Alexiades, George Tessema, Belachew Parisier, Simon TI Glomus Tumors in Patients of Advanced Age: A Conservative Approach SO LARYNGOSCOPE LA English DT Article; Proceedings Paper CT 110th Annual Meeting of the Triological-Society CY APR 26-29, 2007 CL San Diego, CA SP Triol Soc DE Glomus tympanicum; glomus jugulare; paraganglioma; elderly ID SKULL BASE SURGERY; LONG-TERM CONTROL; JUGULARE TUMORS; TYMPANICUM TUMORS; PARAGANGLIOMAS; RADIOSURGERY; MANAGEMENT; LESIONS; NECK; HEAD AB Objectives: Identify and discuss controversies in the management of paragangliomas in elderly patients. Assess and evaluate a conservative treatment strategy involving limited surgical resection and vigilant monitoring of the outcome measures of tumor control, peritreatment morbidity, symptom resolution, and hearing preservation. Study Design: Retrospective case review. Methods: All of the patients in this study were over age 60 with temporal bone glomus tumors. Primary outcome assessment included length of hospitalization, perioperative morbidity, symptom resolution, hearing preservation, and long-term tumor control. Results: Twelve female patients with mean age of 74.5 years (range 61-85 years) with follow-up from 24 months to 33 years (mean/median: 5/7.8 years) were identified. Nine (75%) of the patients presented with pulsatile tinnitus. Seven patients (58%) underwent surgical excision of the middle ear component of the paraganglioma. Tumors extending to the jugular foramen were purposely not resected. Five patients (45%) had relative or absolute contraindications to surgical resection and were treated with observation or primary radiation therapy. Post-treatment audiometric evaluation confirmed stable or improved hearing. Pulsatile tinnitus resolved in all patients. No patient experienced cranial nerve deficits, extended hospitalization, or blood transfusions. All patients were followed closely with radiological imaging. The majority of patients demonstrated no disease or stable disease, while two patients demonstrated tumor growth 6 years after diagnosis. Conclusion: A prolonged natural history and the morbidity associated with surgical intervention have led to controversies in the treatment of glomus tumors in an elderly population. Our experience supports recent limited reports advocating conservative surgical excision and vigilant long-term monitoring in this population. C1 [Cosetti, Maura; Linstrom, Christopher; Alexiades, George; Tessema, Belachew; Parisier, Simon] New York Eye & Ear Infirm, Dept Otolaryngol, New York, NY 10003 USA. RP Linstrom, C (reprint author), New York Eye & Ear Infirm, Dept Otolaryngol, 310 E 14th St,6th Floor, New York, NY 10003 USA. EM clinstrom@nyee.edu CR FISCH U, 1982, ANN OTO RHINOL LARYN, V91, P474 Foote RL, 2002, HEAD NECK-J SCI SPEC, V24, P332, DOI 10.1002/hed.10005 Forest JA, 2001, OTOL NEUROTOL, V22, P232, DOI 10.1097/00129492-200103000-00020 GLASSCOCK ME, 1993, LARYNGOSCOPE, V103, P3 GREEN JD, 1994, LARYNGOSCOPE, V104, P917 Guild SR, 1941, ANAT REC S2, V79, P28 Hu Kenneth, 2003, Oncology (Williston Park), V17, P983 Hu Kenneth, 2003, Oncology (Williston Park), V17, P1143 JACKSON CG, 1989, LARYNGOSCOPE, V99, P875 Jackson CG, 2000, EAR: COMPREHENSIVE OTOLOGY, P813 JACKSON CG, 1982, ARCH OTOLARYNGOL, V108, P401 Jackson CG, 2001, OTOL NEUROTOL, V22, P377, DOI 10.1097/00129492-200105000-00018 JACOBS IN, 1994, ARCH OTOLARYNGOL, V120, P203 Jansen JC, 2000, CANCER, V88, P2811, DOI 10.1002/1097-0142(20000615)88:12<2811::AID-CNCR21>3.0.CO;2-7 KAPADIA SB, 2001, SURG PATHOLOGY HEAD, P830 Krych AJ, 2006, INT J RADIAT ONCOL, V65, P1063, DOI 10.1016/j.ijrobp.2006.02.020 Manolidis S, 1999, LARYNGOSCOPE, V109, P30, DOI 10.1097/00005537-199901000-00007 MEGERIAN CA, 1995, AM J OTOL, V16, P94 NETTERVILLE JL, 1993, LARYNGOSCOPE, V103, P45 Oldring D, 1979, Am J Otol, V1, P7 Pellitteri PK, 2004, ORAL ONCOL, V40, P563, DOI 10.1016/j.oraloncology.2003.09.004 ROSENWASSER H, 1945, ARCH OTOLARYNGOL, V41, P64 Tasar M, 2004, J CRANIOFAC SURG, V15, P497, DOI 10.1097/00001665-200405000-00031 VANDERMEY AGL, 1992, ANN OTO RHINOL LARYN, V101, P635 Willen SN, 2005, OTOL NEUROTOL, V26, P1229, DOI 10.1097/01.mao.0000176170.41399.fd WOODS CI, 1993, LARYNGOSCOPE, V103, P65 NR 26 TC 16 Z9 16 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0023-852X J9 LARYNGOSCOPE JI Laryngoscope PD FEB PY 2008 VL 118 IS 2 BP 270 EP 274 DI 10.1097/MLG.0b013e318158194b PG 5 WC Medicine, Research & Experimental; Otorhinolaryngology SC Research & Experimental Medicine; Otorhinolaryngology GA 368ZE UT WOS:000260661500015 PM 18030172 ER PT J AU Ruf, O AF Ruf, Oliver TI My tinnitus (Robert De Niro) SO MERKUR-DEUTSCHE ZEITSCHRIFT FUR EUROPAISCHES DENKEN LA German DT Article C1 Doktrand Univ Trier & Luxembrug, Literaturwissensch & Kritiker, Luxembourg, Luxembourg. RP Ruf, O (reprint author), Doktrand Univ Trier & Luxembrug, Literaturwissensch & Kritiker, Luxembourg, Luxembourg. EM otiver.ruf@tenderenda.de NR 0 TC 0 Z9 0 PU KLETT-COTTA VERLAG PI STUTTGART 1 PA ROTEBUHLSTRASSE 77, D-7004 9 STUTTGART 1, GERMANY SN 0026-0096 J9 MERKUR-DEUT Z EUR D JI Merkur-Deut. Z. Eur. Denk. PD FEB PY 2008 VL 62 IS 2 BP 176 EP 178 PG 3 WC Humanities, Multidisciplinary SC Arts & Humanities - Other Topics GA 275EX UT WOS:000254055800013 ER PT J AU Shi, ZS Ziegler, J Gonzalez, NR Feng, L Tateshima, S Jahan, R Duckwiler, G Vinuela, F AF Shi, Zhong-Song Ziegler, Jordan Gonzalez, Nestor R. Feng, Lei Tateshima, Satoshi Jahan, Reza Duckwiler, Gary Vinuela, Fernando TI Transarterial embolization of clival dural arteriovenous fistulae using liquid embolic agents SO NEUROSURGERY LA English DT Article DE clivus; dural arteriovenous fistula; embolization; liquid embolic agent ID CAROTID-CAVERNOUS FISTULAS; TRANSVENOUS EMBOLIZATION; TECHNICAL NOTE; MALFORMATIONS; INJECTION; SINUS; MANIFESTATIONS; CLASSIFICATION; CYANOACRYLATE; EXPERIENCE AB OBJECTIVE: Dural arteriovenous fistulae (DAVFs) rarely involve the clivus. This report examines the clinical presentation, angiographic findings, endovascular management, and outcome of clival DAVFs. Particular attention was given to safety and efficacy of transarterial embolization using liquid embolic agents. METHODS: We reviewed the clinical and radiological data of 10 patients with spontaneous clival DAVFs who were treated endovascularly at the University of California at Los Angeles Medical Center between 1992 and 2006. RESULTS: Nine patients presented with ocular symptoms and one patient experienced pulsatile tinnitus. Cerebral angiograms showed that these clival DAVFs were supplied by multiple branches of the internal and external carotid arteries. The patterns of venous drainage were from the clival veins to the cavernous sinus and superior ophthalmic vein in nine patients and to the inferior petrosal sinus in two patients. Six clival DAVFs were embolized transarterially through the clival branches of the ascending pharyngeal artery. Onyx 18 (Micro Therapeutics Inc., Irvine, CA) was used in three patients and n-butyl cyanoacrylate was used in three patients. Immediate complete angiographic obliteration was achieved in three patients. All six patients experienced an angiographic and clinical cure without any complications at 3 months. Two patients were incompletely treated using particles and coils for the relief of the symptoms. Two other patients were completely treated after the recipient clival venous structures were occluded transvenously with coils. CONCLUSION: Clival DAVFs can be misdiagnosed as dural cavernous sinus fistulae. The best treatment is transarterial embolization of the dural feeders using liquid embolic agents. Transvenous occlusion of the cavernous sinus is unnecessary in most cases. C1 [Shi, Zhong-Song; Ziegler, Jordan; Gonzalez, Nestor R.; Feng, Lei; Tateshima, Satoshi; Jahan, Reza; Duckwiler, Gary; Vinuela, Fernando] Univ Calif Los Angeles, Div Intervent Neuroradiol, Los Angeles Med Ctr, Los Angeles, CA 90095 USA. [Shi, Zhong-Song] Sun Yat Sen Univ, First Affiliated Hosp, Dept Neurosurg, Guangzhou, Peoples R China. [Gonzalez, Nestor R.] Univ Calif Los Angeles, Div Neurosurg, Los Angeles Med Ctr, Los Angeles, CA 90095 USA. [Feng, Lei] Kaiser Permanente Med Ctr, Dept Diagnost Imaging, Los Angeles, CA 90034 USA. RP Shi, ZS (reprint author), Univ Calif Los Angeles, Div Intervent Neuroradiol, Los Angeles Med Ctr, 10833 Le Conte Ave, Los Angeles, CA 90095 USA. 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There is considerable discrepancy within the literature regarding the percentage of positive findings in patients with pulsatile tinnitus. The authors discuss the overlap in the radiographic findings detected in association with tinnitus in both asymptomatic patients and Symptomatic patients and the importance for imaging to detect treatable causes. They discuss imaging related to diagnosis and treatment and provide an imaging workup algorithm. C1 [Kang, Melissa; Escott, Edward] Univ Pittsburgh, Med Ctr, Pittsburgh, PA 15213 USA. RP Kang, M (reprint author), 144 Hidden Hollow Terrace,Palm Beach Gardens, Miami, FL 33418 USA. 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Clin. N. Am. PD FEB PY 2008 VL 41 IS 1 BP 179 EP + DI 10.1016/j.otc.2007.10.008 PG 16 WC Otorhinolaryngology SC Otorhinolaryngology GA 270BX UT WOS:000253696000009 PM 18261531 ER PT J AU Stankewitz, A May, A AF Stankewitz, A. May, A. TI Cortical dysbalance in the brain in migraineurs - hyperexcitability as the result of sensitisation? SO SCHMERZ LA German DT Review DE migraine; cortical excitability; habituation; sensitisation; chronicity ID TRANSCRANIAL MAGNETIC STIMULATION; VISUAL-CORTEX EXCITABILITY; INTENSITY DEPENDENCE; EVOKED-POTENTIALS; EPISODIC MIGRAINE; HEADACHE PATIENTS; INHIBITION; MOTOR; AURA; THRESHOLDS AB A cortical dysbalance has a pivotal role in the pathophysiology of migraine. Numerous electrophysiological and transcranial magnetic stimulation (TMS) studies have investigated the interictal excitability level in migraineurs and have shown a consistent lack of habituation during repetitive stimulation. There is some controversy in the current literature over whether this deficit is based on a lowered or an elevated preactivation level. However, the current discussion may be misguided. It seems that multiple external and intrinsic factors influence the level of cortical excitability and the frequency and intensity of attacks: Habituation is specific neither to migraine nor even to pain; the same phenomenon is found in tinnitus patients, for example. Cortical hyperexcitability is presumably the result of chronicity and the concomitant central sensitisation process. C1 [Stankewitz, A.; May, A.] Univ Hamburg, Hosp Eppendorf, Inst Syst Neurowissensch, D-20246 Hamburg, Germany. RP May, A (reprint author), Univ Hamburg, Hosp Eppendorf, Inst Syst Neurowissensch, Martinistr 52, D-20246 Hamburg, Germany. EM a.may@uke.uni-hamburg.de CR Afra J, 1998, ANN NEUROL, V44, P209, DOI 10.1002/ana.410440211 Afra J, 2005, FUNCT NEUROL, V20, P199 Afra J, 2000, CLIN NEUROPHYSIOL, V111, P1124, DOI 10.1016/S1388-2457(00)00271-6 Ambrosini A, 2003, BRAIN, V126, P2009, DOI 10.1093/brain/awg206 Ambrosini A, 2003, CEPHALALGIA, V23, P13, DOI 10.1046/j.1468-2982.2003.00571.x Antal A, 2006, CEPHALALGIA, V26, P865, DOI 10.1111/j.1468-2982.2006.01132.x Aurora SK, 2003, CEPHALALGIA, V23, P258, DOI 10.1046/j.1468-2982.2003.00471.x Aurora SK, 2005, HEADACHE, V45, P546, DOI 10.1111/j.1526-4610.2005.05108.x Battelli L, 2002, NEUROLOGY, V58, P1066 Bohotin V, 2002, BRAIN, V125, P912, DOI 10.1093/brain/awf081 Bohotin V, 2003, CEPHALALGIA, V23, P264, DOI 10.1046/j.1468-2982.2003.00475.x BRIGHINA F, 2007, CEPHALALGIA, V27, P188 Brighina F, 2004, J NEUROL SCI, V227, P67, DOI 10.1016/j.jns.2004.08.008 Brighina F, 2007, CEPHALALGIA, V27, P187, DOI 10.1111/j.1468-2982.2007.01276_1.x Brighina F, 2002, EXP BRAIN RES, V145, P177, DOI 10.1007/s00221-002-1096-7 Buchgreitz L, 2006, PAIN, V123, P19, DOI 10.1016/j.pain.2006.01.040 Chadaide Z, 2007, CEPHALALGIA, V27, P833, DOI 10.1111/j.1468-2982.2007.01337.x del Rio MS, 2004, LANCET NEUROL, V3, P645 Edvinsson L, 2005, BRAIN RES REV, V48, P438, DOI 10.1016/j.brainresrev.2004.09.007 Fann AV, 2005, CLIN NEUROPHYSIOL, V116, P681, DOI 10.1016/j.clinph.2004.09.026 Flor H, 2004, NEUROSCI LETT, V361, P147, DOI 10.1016/j.neulet.2003.12.064 Fumal A, 2006, CEPHALALGIA, V26, P143, DOI 10.1111/j.1468-2982.2005.01013.x Gerber WD, 2002, J PSYCHOSOM RES, V52, P215, DOI 10.1016/S0022-3999(02)00299-4 Walpurger V, 2003, HEARING RES, V181, P57, DOI 10.1016/S0378-5955(03)00172-2 Kitaj MB, 2005, HEADACHE, V45, P992, DOI 10.1111/j.1526-4610.2005.05179.x KROPP P, 2007, CEPHALALGIA, V27, P666 Lang E, 2004, BRAIN, V127, P2459, DOI 10.1093/brain/awh295 Loo CK, 2005, J AFFECT DISORDERS, V88, P255, DOI 10.1016/j.jad.2005.08.001 May A, 2003, NERVENARZT, V74, P1067, DOI 10.1007/s00115-003-1578-2 McColl SL, 2000, CEPHALALGIA, V20, P74, DOI 10.1046/j.1468-2982.2000.00033.x Mulder EJCM, 2001, HEADACHE, V41, P72, DOI 10.1046/j.1526-4610.2001.111006072.x Mulleners WM, 2001, HEADACHE, V41, P565, DOI 10.1046/j.1526-4610.2001.041006565.x Nitsche MA, 2006, EUR J NEUROSCI, V23, P1651, DOI 10.1111/j.1460-9568.2006.04676.x Palmer JE, 2000, CEPHALALGIA, V20, P525, DOI 10.1046/j.1468-2982.2000.00075.x Sandor PS, 2000, FUNCT NEUROL, V15, P68 Schoenen J, 2003, CLIN NEUROPHYSIOL, V114, P955, DOI 10.1016/S1388-2457(03)00024-5 Siniatchkin M, 2006, NEUROSCI LETT, V400, P121, DOI 10.1016/j.neulet.2006.02.019 Wessman M, 2007, LANCET NEUROL, V6, P521, DOI 10.1016/S1474-4422(07)70126-6 NR 38 TC 5 Z9 5 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013 USA SN 0932-433X J9 SCHMERZ JI Schmerz PD FEB PY 2008 VL 22 SU 1 BP 17 EP 21 DI 10.1007/s00482-007-0612-x PG 5 WC Anesthesiology; Clinical Neurology SC Anesthesiology; Neurosciences & Neurology GA 269VU UT WOS:000253679400004 PM 18228046 ER PT J AU Kahlbrock, N Weisz, N AF Kahlbrock, Nina Weisz, Nathan TI Transient reduction of tinnitus intensity is marked by concomitant reductions of delta band power SO BMC BIOLOGY LA English DT Article ID PRIMARY AUDITORY-CORTEX; INDUCED HEARING-LOSS; BRAIN ACTIVITY; MECHANISMS; INHIBITION; PERCEPTION; SALICYLATE; DORSAL; MEG AB Background: Tinnitus is an auditory phantom phenomenon characterized by the sensation of sounds without objectively identifiable sound sources. To date, its causes are not well understood. Previous research found altered patterns of spontaneous brain activity in chronic tinnitus sufferers compared to healthy controls, yet it is unknown whether these abnormal oscillatory patterns are causally related to the tinnitus sensation. Partial support for this notion comes from a neurofeedback approach developed by our group, in which significant reductions in tinnitus loudness could be achieved in patients who successfully normalized their patterns of spontaneous brain activity. The current work attempts to complement these studies by scrutinizing how modulations of tinnitus intensity alter ongoing oscillatory activity. Results: In the present study the relation between tinnitus sensation and spontaneous brain activity was investigated using residual inhibition (RI) to reduce tinnitus intensity and source-space projected magnetencephalographic (MEG) data to index brain activity. RI is the sustained reduction (criteria: 50% for at least 30 s) in tinnitus loudness after cessation of a tonal tinnitus masker. A pilot study (n = 38) identified 10 patients who showed RI. A significant reduction of power in the delta (1.3-4.0 Hz) frequency band was observed in temporal regions during RI (p <= 0.001). Conclusion: The current results suggest that changes of tinnitus intensity induced by RI are mediated by alterations in the pathological patterns of spontaneous brain activity, specifically a reduction of delta activity. Delta activity is a characteristic oscillatory activity generated by deafferented/deprived neuronal networks. This implies that RI effects might reflect the transient reestablishment of balance between excitatory and inhibitory neuronal assemblies, via reafferentation, that have been perturbed (in most tinnitus individuals) by hearing damage. As enhancements have been reported in the delta frequency band for tinnitus at rest, this result conforms to our assumption that a normalization of oscillatory properties of cortical networks is a prerequisite for attenuating the tinnitus sensation. For RI to have therapeutic significance however, this normalization would have to be stabilized. C1 [Kahlbrock, Nina] Univ Konstanz, Dept Psychol, Constance, Germany. [Weisz, Nathan] INSERM, U821, Brain Dynam & Cognit Lab, F-69008 Lyon, France. RP Kahlbrock, N (reprint author), Univ Konstanz, Dept Psychol, Constance, Germany. 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PD JAN 16 PY 2008 VL 6 AR 4 DI 10.1186/1741-7007-6-4 PG 9 WC Biology SC Life Sciences & Biomedicine - Other Topics GA 269XX UT WOS:000253685200001 PM 18199318 ER PT J AU Zheng, Y Hooton, K Smith, PF Darlington, CL AF Zheng, Yiwen Hooton, Katie Smith, Paul F. Darlington, Cynthia L. TI Carbamazepine reduces the behavioural manifestations of tinnitus following salicylate treatment in rats SO ACTA OTO-LARYNGOLOGICA LA English DT Article DE tinnitus; salicylate; carbamazepine ID PHANTOM AUDITORY-PERCEPTION; PSYCHOMOTOR FUNCTION; INTENSE SOUND; ANIMAL-MODEL; CA1 NEURONS; CURRENTS; PHARMACOKINETICS; EXPOSURE AB Conclusion. The results are consistent with the hypothesis that carbarmazepine (CBZ) has efficacy against tinnitus in humans. Objective. CBZ is an anti-epileptic drug that is widely used for the treatment of tinnitus. Despite this, there are relatively few clinical trials or preclinical studies supporting its efficacy. In an effort to increase the amount of information available on CBZ, the aim of this study was to investigate the efficacy of CBZ in salicylate-induced tinnitus in rats Materials and methods. We investigated the effects of CBZ in an animal model of tinnitus induced by the injection of salicylate using a conditioned lick suppression paradigm. Results. We found that CBZ, at a dose of 15 mg/kg i.p., but not at 5 mg/kg or 30 mg/kg, significantly suppressed the behavioural manifestations of tinnitus. C1 [Zheng, Yiwen; Hooton, Katie; Smith, Paul F.; Darlington, Cynthia L.] Univ Otago, Sch Med Sci, Dept Pharmacol & Toxicol, Dunedin, New Zealand. RP Smith, PF (reprint author), Univ Otago, Sch Med Sci, Dept Pharmacol & Toxicol, Dunedin, New Zealand. 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PY 2008 VL 128 IS 1 BP 48 EP 52 DI 10.1080/00016480701361939 PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA 244CC UT WOS:000251842600009 PM 17851905 ER PT J AU Quaranta, N Fernandez-Vega, S D'Elia, C Filipo, R Quaranta, A AF Quaranta, Nicola Fernandez-Vega, Susana D'Elia, Chiara Filipo, Roberto Quaranta, Antonio TI The effect of unilateral multichannel cochlear implant on bilaterally perceived tinnitus SO ACTA OTO-LARYNGOLOGICA LA English DT Article DE cochlear implant; tinnitus; plasticity ID ELECTRICAL-STIMULATION; SUPPRESSION; PLASTICITY AB Conclusions. Available multichannel cochlear implants (CIs) provide effective tinnitus suppression. More sophisticated speech strategies are more effective than analogue or slow strategies. The mechanisms by which tinnitus is suppressed by CIs are unclear; however, both acoustic masking and reorganization of the right auditory association cortex induced by the CI are possible mechanisms. CI significantly reduced the tinnitus-related handicap as assessed by the Tinnitus handicap Inventory (THI). Objective. The objective of the study was to evaluate the effects of a unilateral CI on bilaterally perceived tinnitus. Patients and methods. Forty-one profoundly deaf patients implanted with a multichannel CI reporting bilateral tinnitus were evaluated. All patients were asked to complete a questionnaire that evaluated the presence, location and intensity of tinnitus before and after cochlear implantation. Results. Seven patients (17%) reported the perception of a 'new tinnitus' after surgery. With the CI off tinnitus was abolished in 23 patients (56.1%) in the implanted ear and in 22 patients (53.6%) in the contralateral ear. With the CI on tinnitus was abolished in the ipsilateral ear in 27 patients (65.8%) and in the contralateral ear in 27 patients (65.8%). Statistical analysis showed a significant reduction of the total THI score and of each subscale score (p <0.001). C1 [Quaranta, Nicola; Fernandez-Vega, Susana; Quaranta, Antonio] Univ Bari, Dept Ophthalmol & Otorhinolaryngol, Otorhinolaryngol Clin, I-70124 Bari, Italy. [D'Elia, Chiara; Filipo, Roberto] Univ Roma La Sapienza, Dept Neurol & Otolaryngol, Rome, Italy. RP Quaranta, N (reprint author), Univ Bari, Dept Ophthalmol & Otorhinolaryngol, Otorhinolaryngol Clin, Pzza G Cesare, I-70124 Bari, Italy. EM nicola.quaranta@orl.uniba.it CR Baguley DM, 2002, BRIT MED BULL, V63, P195, DOI 10.1093/bmb/63.1.195 Baguley D M, 2003, Am J Audiol, V12, P31, DOI 10.1044/1059-0889(2003/007) BATTMER RD, 1989, HNO, V37, P148 Demajumdar R, 1999, J Laryngol Otol Suppl, V24, P24 Gabriel D, 2006, HEARING RES, V213, P49, DOI 10.1016/j.heares.2005.12.007 ITO J, 1994, LARYNGOSCOPE, V104, P752 KIM HN, 1995, P 5 INT TINN SEM POR Lockwood AH, 2001, NEUROLOGY, V56, P472 MCKERROW WS, 1991, ANN OTO RHINOL LARYN, V100, P552 McKinney CJ, 2002, P 7 INT TINN SEM, P176 Miyamoto R, 1997, INT TINNITUS J, V3, P35 Mo B, 2002, INT J AUDIOL, V41, P527, DOI 10.3109/14992020209056073 Newman CW, 1996, ARCH OTOLARYNGOL, V122, P143 Osaki Y, 2005, NEUROREPORT, V16, P1625, DOI 10.1097/01.wnr.0000183899.85277.08 Philibert B, 2005, HEARING RES, V205, P131, DOI 10.1016/j.heares.2005.03.013 Pinchoff RJ, 1998, AM J OTOL, V19, P785 Quaranta N, 2004, INT J AUDIOL, V43, P245, DOI 10.1080/14992020400050033 Reyes SA, 2002, HEARING RES, V171, P43, DOI 10.1016/S0378-5955(02)00346-5 Salvi R. J., 2000, TINNITUS HDB, P123 SNACHEZ L, 2004, AUDIOLOGICAL MED, V2, P8 SOULIERE CR, 1992, ARCH OTOLARYNGOL, V118, P1291 TYLER RS, 1994, AM J OTOL, V15, P523 NR 22 TC 18 Z9 21 PU TAYLOR & FRANCIS AS PI OSLO PA PO BOX 12 POSTHUSET, NO-0051 OSLO, NORWAY SN 0001-6489 J9 ACTA OTO-LARYNGOL JI Acta Oto-Laryngol. PY 2008 VL 128 IS 2 BP 159 EP 163 DI 10.1080/00016480701387173 PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA 252OD UT WOS:000252454900008 PM 17851950 ER PT J AU Hatanaka, A Ariizumi, Y Kitamura, K AF Hatanaka, Akio Ariizumi, Yousuke Kitamura, Ken TI Pros and cons of tinnitus retraining therapy SO ACTA OTO-LARYNGOLOGICA LA English DT Article DE Tinnitus Handicap Inventory (THI); tinnitus control instrument (TCI); visual analogue scale of annoyance caused by tinnitus (VAS) AB Conclusions. A significant reduction in the Tinnitus Handicap Inventory (THI) was obtained as early as 1 month after implementation of tinnitus retraining therapy (TRT). Over half of our patients either could not tolerate the tinnitus control instrument (TCI) or obtained a poor result in the TRT trial. Candidates for TRT should thus be restricted to patients who can use the TCI. Objectives. TRT has been regarded as a promising therapy for tinnitus, although there have been very few studies to determine which patients are most likely to benefit from TRT. The aim of the present study was to demonstrate TRT's pros and cons based on our experience. Subjects and methods. The subjects were 217 patients with intractable tinnitus. Of those, 84 tolerated TRT and 79 were followed for 6 months. The remaining subjects did not undergo TRT. Japanese translations of the THI and visual analogue scale of annoyance caused by tinnitus (VAS) were administered to evaluate the effect of TRT. Results. The average THI score at the beginning of the treatment was 48.8, but it was 36.3 (p < 0.01) 1 month after starting the treatment and 28.3 (p < 0.005) after 6 months. C1 [Hatanaka, Akio; Ariizumi, Yousuke; Kitamura, Ken] Tokyo Med & Dent Univ, Dept Otolaryngol, Grad Sch, Bunkyo Ku, Tokyo 1138519, Japan. RP Kitamura, K (reprint author), Tokyo Med & Dent Univ, Dept Otolaryngol, Grad Sch, Bunkyo Ku, 1-5-45 Yushima, Tokyo 1138519, Japan. EM kitamura.oto@tmd.ac.jp CR Berry JA, 2002, ARCH OTOLARYNGOL, V128, P1153 Coles R R, 1984, J Laryngol Otol Suppl, V9, P7 Dobie RA, 1999, LARYNGOSCOPE, V109, P1202, DOI 10.1097/00005537-199908000-00004 HARRAIZ C, 1999, P 4 INT TINN SEM, P483 HEIZMANN T, 1999, P 4 INT TINN SEM, V509, P11 Jastreboff PJ, 1996, AM J OTOL, V17, P236 Jastreboff PJ, 2003, OTOLARYNG CLIN N AM, V36, P321, DOI 10.1016/S0030-6665(02)00172-X LUXON LM, 1993, BRIT MED J, V306, P1490 Mazurek B, 2006, AUDIOL NEURO-OTOL, V11, P276, DOI 10.1159/000093526 MCKINNEY CJ, 1999, P 4 INT TINN SEM, V99, P105 Newman CW, 1996, ARCH OTOLARYNGOL, V122, P143 Shinden S, 2002, AUDIOL JPN, V45, P685, DOI 10.1002/14651858 Zenner HP, 2006, OTOL NEUROTOL, V27, P1054, DOI 10.1097/01.mao.0000231604.64079.77 NR 13 TC 10 Z9 11 PU TAYLOR & FRANCIS AS PI OSLO PA PO BOX 12 POSTHUSET, NO-0051 OSLO, NORWAY SN 0001-6489 J9 ACTA OTO-LARYNGOL JI Acta Oto-Laryngol. PY 2008 VL 128 IS 4 BP 365 EP 368 DI 10.1080/00016480701730760 PG 4 WC Otorhinolaryngology SC Otorhinolaryngology GA 279ZL UT WOS:000254394600005 PM 18368566 ER PT J AU Lanting, CP De Kleine, E Bartels, H Van Dijk, P AF Lanting, C. P. De Kleine, E. Bartels, H. Van Dijk, P. TI Functional imaging of unilateral tinnitus using fMRI SO ACTA OTO-LARYNGOLOGICA LA English DT Article DE fMRI; tinnitus; central auditory system; auditory cortex; inferior colliculus ID DORSAL COCHLEAR NUCLEUS; PRIMARY AUDITORY-CORTEX; LATERALIZED TINNITUS; PULSATILE TINNITUS; ACTIVATION AB Conclusions. This article shows that the inferior colliculus plays a key role in unilateral subjective tinnitus. Objectives. The major aim of this study was to determine tinnitus-related neural activity in the central auditory system of unilateral tinnitus subjects and compare this to control subjects without tinnitus. Subjects and methods. Functional MRI (fMRI) was performed in 10 patients (5 males) with unilateral tinnitus (5 left-sided, 5 right-sided) and 12 healthy subjects (6 males); both groups had normal hearing or mild hearing loss. fMRI experiments were performed using a 3T Philips Intera Scanner. Auditory stimuli were presented left or right and consisted of dynamically rippled broadband noise with a sound pressure level of 40 or 70 dB SPL. The responses of the inferior colliculus and the auditory cortex to the stimuli were measured. Results. The response to sound in the inferior colliculus was elevated in tinnitus patients compared with controls without tinnitus. C1 [Lanting, C. P.; De Kleine, E.; Bartels, H.; Van Dijk, P.] Univ Med Ctr Groningen, Dept Otorhinolaryngol Head & Neck Surg, NL-9700 RB Groningen, Netherlands. [Lanting, C. P.; De Kleine, E.; Bartels, H.; Van Dijk, P.] Univ Groningen, Fac Med Sci, Sch Behav & Cognit Neurosci, Groningen, Netherlands. RP Lanting, CP (reprint author), Univ Med Ctr Groningen, Dept Otorhinolaryngol Head & Neck Surg, POB 30-001, NL-9700 RB Groningen, Netherlands. EM c.p.lanting@med.umcg.nl RI Van Dijk, Pim/E-8019-2010; de Kleine, Emile/P-2350-2014 OI Van Dijk, Pim/0000-0002-8023-7571; CR Abdul-Baqi KJ, 2004, J LARYNGOL OTOL, V118, P231 AXELSSON A, 1989, British Journal of Audiology, V23, P53, DOI 10.3109/03005368909077819 Baumgart F, 1998, MED PHYS, V25, P2068, DOI 10.1118/1.598368 BERLINER KI, 1992, AM J OTOL, V13, P13 Devlin JT, 2003, J NEUROSCI, V23, P11516 Eggermont JJ, 2004, TRENDS NEUROSCI, V27, P676, DOI 10.1016/j.tins.2004.08.010 Hall DA, 1999, HUM BRAIN MAPP, V7, P213, DOI 10.1002/(SICI)1097-0193(1999)7:3<213::AID-HBM5>3.0.CO;2-N House J W, 1981, Ciba Found Symp, V85, P204 Kaltenbach JA, 2006, HEARING RES, V216, P224, DOI 10.1016/j.heares.2006.01.002 Kaltenbach JA, 2006, ACTA OTO-LARYNGOL, V126, P20, DOI 10.1080/03655230600895309 Langers DRM, 2003, NEUROIMAGE, V20, P265, DOI 10.1016/S1053-8119(03)00258-1 Liyanage SH, 2006, J LARYNGOL OTOL, V120, P93, DOI 10.1017/S0022215105001714 Lockwood AH, 2002, NEW ENGL J MED, V347, P904, DOI 10.1056/NEJMra013395 Melcher JR, 2000, J NEUROPHYSIOL, V83, P1058 Norena AJ, 2003, HEARING RES, V183, P137, DOI 10.1016/S0378-5955(03)00225-9 OLDFIELD RC, 1971, NEUROPSYCHOLOGIA, V9, P97, DOI 10.1016/0028-3932(71)90067-4 Salvi RJ, 2000, HEARING RES, V147, P261, DOI 10.1016/S0378-5955(00)00136-2 Seki S, 2003, HEARING RES, V180, P28, DOI 10.1016/S0378-5955(03)00074-1 Smits M, 2007, NEURORADIOLOGY, V49, P669, DOI 10.1007/s00234-007-0231-3 Sonmez G, 2007, CLIN IMAG, V31, P102, DOI 10.1016/j.clinimag.2006.12.024 NR 20 TC 40 Z9 46 PU TAYLOR & FRANCIS AS PI OSLO PA PO BOX 12 POSTHUSET, NO-0051 OSLO, NORWAY SN 0001-6489 J9 ACTA OTO-LARYNGOL JI Acta Oto-Laryngol. PY 2008 VL 128 IS 4 BP 415 EP 421 DI 10.1080/00016480701793743 PG 7 WC Otorhinolaryngology SC Otorhinolaryngology GA 279ZL UT WOS:000254394600015 PM 18368576 ER PT J AU Mattox, DE Hudgins, P AF Mattox, Douglas E. Hudgins, Patricia TI Algorithm for evaluation of pulsatile tinnitus SO ACTA OTO-LARYNGOLOGICA LA English DT Article DE tinnitus; objective tinnitus; vascular abnormality; diverticulum AB Conclusions. Pulsatile tinnitus requires a careful physical examination and evaluation with selected imaging techniques to identify the origin of the symptoms. Objective. To evaluate the incidence of identifiable anomalies in patients with pulsatile tinnitus. Subjects and methods. This was a retrospective chart review undertaken in a tertiary care center. Patients seen in the outpatient otolaryngology clinic with the chief complaint of pulsatile tinnitus were evaluated by physical examination and imaging including CT angiography. The outcome measure was the incidence of identifiable abnormalities on imaging studies. Results. Fifty-four patients were seen between January 2002 and June 2007 with the chief complaint of constant pulsatile tinnitus, excluding those with chemodectomas. On the basis of physical examination and imaging, 14 were considered arterial, 23 venous, and 15 were indeterminate in origin. Among patients with venous tinnitus, sigmoid sinus diverticulum was the most common finding. Among patients with arterial tinnitus, carotid atherosclerotic disease was the most common. One patient had erosion of the cochlea by the carotid artery. Non-vascular entities identified include superior semicircular canal dehiscence and benign intracranial hypertension. C1 [Mattox, Douglas E.] Emory Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, Atlanta, GA 30322 USA. [Hudgins, Patricia] Emory Univ, Sch Med, Dept Radiol, Div Neuroradiol, Atlanta, GA 30322 USA. RP Mattox, DE (reprint author), Emory Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, 1365 Clifton Rd NE,Room A2328, Atlanta, GA 30322 USA. EM douglas.mattox@emory.edu CR Krishnan A, 2006, AM J NEURORADIOL, V27, P1635 Otto KJ, 2007, OTOL NEUROTOL, V28, P48, DOI 10.1097/01.mao.0000247814.85829.f6 Pirodda A, 2005, ARCH OTOLARYNGOL, V131, P728, DOI 10.1001/archotol.131.8.728 Sismanis A, 2003, OTOLARYNG CLIN N AM, V36, P389, DOI 10.1016/S0030-6665(02)00169-X Sonmez G, 2007, CLIN IMAG, V31, P102, DOI 10.1016/j.clinimag.2006.12.024 NR 5 TC 21 Z9 22 PU TAYLOR & FRANCIS AS PI OSLO PA PO BOX 12 POSTHUSET, NO-0051 OSLO, NORWAY SN 0001-6489 J9 ACTA OTO-LARYNGOL JI Acta Oto-Laryngol. PY 2008 VL 128 IS 4 BP 427 EP 431 DI 10.1080/00016480701840106 PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA 279ZL UT WOS:000254394600017 PM 18368578 ER PT J AU Sugiura, S Uchida, Y Nakashima, T Yoshioka, M Ando, F Shimokata, H AF Sugiura, Saiko Uchida, Yasue Nakashima, Tsutomu Yoshioka, Mayumi Ando, Fujiko Shimokata, Hiroshi TI Tinnitus and brain MRI findings in Japanese elderly SO ACTA OTO-LARYNGOLOGICA LA English DT Article DE tinnitus; cerebral infarction; population-based study; magnetic resonance imaging ID OLDER-ADULTS; HEARING-LOSS; POPULATION AB Conclusion. There is evidence of an inverse association between cerebral infarction and tinnitus in this study. The effects of cerebral infarction on tinnitus could be explained by a neurophysiological model of tinnitus. Objectives. We examined the relationship between tinnitus and brain MRI findings including cerebral infarction, brain atrophy, ventricular dilatation, and white matter lesions. Subjects and methods. This was a cross-sectional population-based study of 2193 subjects aged 41-82 years living in Aichi prefecture, Japan. Detailed questionnaires, pure tone audiometry, and brain MRI were performed. Results. After adjusting for potential confounders in a multiple logistic analysis, cerebral infarction was inversely associated with tinnitus (odds ratio (OR)=0.649, 95% confidence interval (CI)=0.477-0.884). Cerebral infarctions of the basal ganglia (OR=0.542), thalamus (OR=0.441), and pons (OR=0.319) were especially associated with tinnitus. Brain atrophy, ventricular dilatation, and white matter lesions had no significant effects on the prevalence of tinnitus. C1 [Sugiura, Saiko; Uchida, Yasue] Natl Ctr Geriatr & Gerontol, Dept Otorhinolaryngol, Aichi 4748511, Japan. [Nakashima, Tsutomu; Yoshioka, Mayumi] Nagoya Univ, Grad Sch Med, Dept Otorhinolaryngol, Nagoya, Aichi 4648601, Japan. [Ando, Fujiko; Shimokata, Hiroshi] Natl Ctr Geriatr & Gerontol, Dept Epidemiol, Aichi 4748511, Japan. RP Sugiura, S (reprint author), Natl Ctr Geriatr & Gerontol, Dept Otorhinolaryngol, 36-3 Gengo, Aichi 4748511, Japan. EM saiko@ncgg.go.jp RI Nakashima, Tsutomu/B-8259-2012 OI Nakashima, Tsutomu/0000-0003-3930-9120 CR Brozoski TJ, 2005, HEARING RES, V206, P227, DOI 10.1016/j.heares.2004.12.013 CHUNG DY, 1984, AUDIOLOGY, V23, P441 Coles R. R. A., 1995, MECH TINNITUS, P11 Dobie R, 2004, TINNITUS THEORY MANA, P1 Eggermont JJ, 2005, DRUG DISCOV TODAY, V10, P1283, DOI 10.1016/S1359-6446(05)03542-7 Hausler R, 2000, ACTA OTO-LARYNGOL, V120, P689 JASTREBOFF PJ, 1990, NEUROSCI RES, V8, P221, DOI 10.1016/0168-0102(90)90031-9 Kubo T, 2000, ACTA OTO-LARYNGOL, P34 Lowry LD, 2004, OTOL NEUROTOL, V25, P474, DOI 10.1097/00129492-200407000-00013 MANOLIO TA, 1994, STROKE, V25, P318 Marcondes Renata, 2006, Ear Nose Throat J, V85, P233 Marcondes R, 2006, ENT-EAR NOSE THROAT, V85, P236 Matsubayashi K, 1997, STROKE, V28, P2169 MEGURO K, 1993, NEURORADIOLOGY, V35, P125 Muhlau M, 2006, CEREB CORTEX, V16, P1283, DOI 10.1093/cercor/bhj070 Nondahl David M, 2002, J Am Acad Audiol, V13, P323 Schick B, 2001, OTOL NEUROTOL, V22, P808, DOI 10.1097/00129492-200111000-00016 Shimokata H, 2000, J Epidemiol, V10, pS1 SIMON MC, 1995, NAT GENET, V11, P9, DOI 10.1038/ng0995-9 Sindhusake Doungkamol, 2004, J Am Acad Audiol, V15, P269 Sindhusake D, 2003, EAR HEARING, V24, P501, DOI 10.1097/01.AUD.0000100204.08771.3D Uchida Y, 2006, AURIS NASUS LARYNX, V33, P397, DOI 10.1016/j.anl.2006.03.002 Yamashita K, 1996, INTERNAL MED, V35, P704, DOI 10.2169/internalmedicine.35.704 NR 23 TC 1 Z9 1 PU TAYLOR & FRANCIS AS PI OSLO PA PO BOX 12 POSTHUSET, NO-0051 OSLO, NORWAY SN 0001-6489 J9 ACTA OTO-LARYNGOL JI Acta Oto-Laryngol. PY 2008 VL 128 IS 5 BP 525 EP 529 DI 10.1080/00016480701558930 PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA 289GE UT WOS:000255042200006 PM 18421606 ER PT J AU Postema, RJ Kingma, CM Wit, HP Albers, FWJ Van der Laan, BFAM AF Postema, Rolf J. Kingma, Charlotte M. Wit, Hero P. Albers, Frans W. J. Van Der Laan, Bernard F. A. M. TI Intratympanic gentamicin therapy for control of vertigo in unilateral Meniere's disease: a prospective, double-blind, randomized, placebo-controlled trial SO ACTA OTO-LARYNGOLOGICA LA English DT Article DE aminoglycosides; gentamicin; intratympanic; Meniere's disease; aural fullness ID METAANALYSIS AB Conclusions. Intratympanic application of gentamicin is a relatively safe and efficient treatment for the reduction of complaints of vertigo attacks associated with Meniere's disease. The treatment also reduces the severity of the perceived aural fullness. Objective. To investigate the effectiveness of intratympanic gentamicin treatment in patients with unilateral Meniere's disease. Subjects and methods. In a prospective, double-blind, randomized, placebo-controlled clinical trial subjects scored vertigo complaints, aural fullness and tinnitus, before, during and up to 1 year after treatment. Hearing loss was monitored with pure tone audiometry. Results. Gentamicin treatment resulted in a significant reduction of the score for vertigo complaints and the score for perceived aural fullness. A small increase in hearing loss (average 8 dB) was measured in the gentamicin group. C1 [Postema, Rolf J.; Kingma, Charlotte M.; Wit, Hero P.; Van Der Laan, Bernard F. A. M.] Univ Groningen, Univ Med Ctr Groningen, Dept Otorhinolaryngol, NL-9700 RB Groningen, Netherlands. [Albers, Frans W. J.] Univ Med Ctr Utrecht, Dept Otorhinolaryngol, Utrecht, Netherlands. RP Wit, HP (reprint author), Univ Groningen, Univ Med Ctr Groningen, Dept Otorhinolaryngol, POB 30001, NL-9700 RB Groningen, Netherlands. EM h.p.wit@med.umcg.nl RI van der Laan, Bernard/H-2420-2011 OI van der Laan, Bernard/0000-0002-5016-2871 CR AAO-HNS, 1995, OTOLARYNGOL HEAD NEC, V113, P181 Abou-Halawa AS, 2002, OTOL NEUROTOL, V23, P494, DOI 10.1097/00129492-200207000-00018 Chia SH, 2004, OTOL NEUROTOL, V25, P544, DOI 10.1097/00129492-200407000-00023 Cohen-Kerem R, 2004, LARYNGOSCOPE, V114, P2085, DOI 10.1097/01.mlg.0000149439.43478.24 MATEIJSEN DJM, 2001, THESIS RIJKSUNIVERSI SCHUKNECHT H F, 1957, Acta Otolaryngol Suppl, V132, P1 Stokroos R, 2004, ACTA OTO-LARYNGOL, V124, P172, DOI 10.1080/00016480410016621 ZUCCA G, 1991, ACTA OTO-LARYNGOL, V111, P820, DOI 10.3109/00016489109138417 NR 8 TC 20 Z9 21 PU INFORMA HEALTHCARE PI LONDON PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND SN 0001-6489 J9 ACTA OTO-LARYNGOL JI Acta Oto-Laryngol. PY 2008 VL 128 IS 8 BP 876 EP 880 DI 10.1080/00016480701762458 PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA 323SJ UT WOS:000257468400008 PM 18607963 ER PT J AU Ylikoski, J Mrena, R Makitie, A Kuokkanen, J Pirvola, U Savolainen, S AF Ylikoski, J. Mrena, R. Makitie, A. Kuokkanen, J. Pirvola, U. Savolainen, S. TI Hyperbaric oxygen therapy seems to enhance recovery from acute acoustic trauma SO ACTA OTO-LARYNGOLOGICA LA English DT Article DE hearing loss; tinnitus; audiometry; recovery ID INDUCED HEARING-LOSS; KINASE ACTIVATION; INNER-EAR; TINNITUS; COCHLEAR; RESCUE; DAMAGE AB Conclusion. The average recovery of hearing and cessation of tinnitus was significantly better after hyperbaric oxygen therapy (HBOT) than after normobaric oxygen therapy (NBOT). HBOT can be valuable adjuvant therapy for patients with acute acoustic trauma (AAT). Objectives. AAT was one of the early indications for the use of HBOT. The rationale of administering oxygen to patients with AAT is based on experimental studies showing that noise exposure results in cochlear hypoxia, which could be compensated by HBOT. The aim of this study was to investigate the efficacy of HBOT in patients with AAT. Patients and methods. We compared the recovery from hearing impairment and tinnitus in 60 ears treated with HBOT with 60 ears treated with NBOT. The HBOT was given daily for 1-8 days. There were no significant differences in clinical or audiological data between HBOT and NBOT groups. Results. The average recovery of hearing both at high and speech frequencies was significantly better and tinnitus persisted less commonly after the HBOT than after the NBOT. Normal hearing at the end of the follow-up period was regained in 42 ears in the HBOT group and in 24 ears in the NBOT group (p < 0.01). C1 [Ylikoski, J.] Univ Helsinki, Helsinki Ear Inst, FIN-00420 Helsinki, Finland. Univ Helsinki, Dept Otolaryngol, FIN-00420 Helsinki, Finland. Univ Helsinki, Inst Biotechnol, FIN-00420 Helsinki, Finland. Ctr Mil Med, Helsinki, Finland. RP Ylikoski, J (reprint author), Univ Helsinki, Helsinki Ear Inst, Halsuantie 1, FIN-00420 Helsinki, Finland. EM jukka.ylikoski@fimnet.fi CR Bennett MH, 2005, COCHRANE DB SYST REV, V25, DOI DOI 10.1002/14651858.CD004739.PUB2 Cheng Alan G, 2005, Curr Opin Otolaryngol Head Neck Surg, V13, P343, DOI 10.1097/01.moo.0000186799.45377.63 Chung JW, 2004, NEUROREPORT, V15, P2353, DOI 10.1097/00001756-200410250-00010 Coleman JKM, 2007, HEARING RES, V226, P104, DOI 10.1016/j.heares.2006.08.008 Comerford KM, 2004, CANCER RES, V64, P9057, DOI 10.1158/0008-5472.CAN-04-1919 Davis PB, 2007, EAR HEARING, V28, P242, DOI 10.1097/AUD.0b013e3180312619 Jastreboff PJ, 1999, BRIT J AUDIOL, V33, P68 Kopke RD, 2002, LARYNGOSCOPE, V112, P1515, DOI 10.1097/00005537-200209000-00001 LAMM C, 1988, HNO, V36, P363 LAMM H, 1995, OTO RHINO LARYN NOVA, V5, P161 Lamm K, 1996, Audiol Neurootol, V1, P148 Lamm K, 1998, ADV OTO-RHINO-LARYNG, V54, P86 Mrena R, 2002, AUDIOL NEURO-OTOL, V7, P122, DOI 10.1159/000057660 Norena AJ, 2005, J NEUROSCI, V25, P699, DOI 10.1523/JNEUROSCI.2226-04.2005 PEKKARINEN JO, 1992, J ACOUST SOC AM, V91, P196, DOI 10.1121/1.402754 PILGRAMM M, 1985, ARCH OTO-RHINO-LARYN, V241, P247, DOI 10.1007/BF00453696 Pirvola U, 2000, J NEUROSCI, V20, P43 PROBST R, 1992, ACTA OTO-LARYNGOL, V112, P435, DOI 10.3109/00016489209137424 SPOENDLI.H, 1971, ACTA OTO-LARYNGOL, V71, P166, DOI 10.3109/00016487109125346 Thom SR, 1992, HYPERBARIC OXYGEN TH Vavrina J, 1995, Rev Laryngol Otol Rhinol (Bord), V116, P377 Ylikoski J, 2002, HEARING RES, V166, P33, DOI 10.1016/S0378-5955(01)00388-4 NR 22 TC 6 Z9 6 PU INFORMA HEALTHCARE PI LONDON PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND SN 0001-6489 J9 ACTA OTO-LARYNGOL JI Acta Oto-Laryngol. PY 2008 VL 128 IS 10 BP 1110 EP 1115 DI 10.1080/00016480801901634 PG 6 WC Otorhinolaryngology SC Otorhinolaryngology GA 346WF UT WOS:000259099600009 PM 18607951 ER PT J AU Marchese-Ragona, R Marioni, G Marson, P Martini, A Staffieri, A AF Marchese-Ragona, Rosario Marioni, Gino Marson, Piero Martini, Alessandro Staffieri, Alberto TI The discovery of salicylate ototoxicity SO AUDIOLOGY AND NEURO-OTOLOGY LA English DT Article DE salicylate ototoxicity; tinnitus; hearing loss; Cesare Bertagnini AB Although the name of the discoverer of salicylate ototoxicity is still debated, most authors have quoted Muller and his 1877 report. To the best of our knowledge, the true discoverer of the transient ototoxicity of salicylate was the Italian chemist Cesare Bertagnini who reported this evidence in 1855 in the journal II Nuovo Cimento. Copyright (C) 2008 S. Karger AG, Basel. C1 [Marchese-Ragona, Rosario; Marioni, Gino; Staffieri, Alberto] Univ Padua, Dept Med & Surg Specialties, Otolaryngol Sect, I-35100 Padua, Italy. [Marson, Piero] Univ Hosp Padova, Blood Bank, Apheresis Unit, Padua, Italy. [Martini, Alessandro] Univ Ferrara, Audiol & ENT Clin Inst, Ferrara, Italy. RP Marchese-Ragona, R (reprint author), Univ Padua, Dept Med & Surg Specialties, Otolaryngol Sect, Via Giustiniani 2, I-35100 Padua, Italy. 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PY 2008 VL 13 IS 1 BP 34 EP 36 DI 10.1159/000107469 PG 3 WC Audiology & Speech-Language Pathology; Neurosciences; Otorhinolaryngology SC Audiology & Speech-Language Pathology; Neurosciences & Neurology; Otorhinolaryngology GA 243ZJ UT WOS:000251835500006 PM 17715468 ER PT J AU Rocha, CACB Sanchez, TG de Siqueira, JTT AF Rocha, Carina A. C. Bezerra Sanchez, Tanit Ganz de Siqueira, Jose T. Tesseroli TI Myofascial trigger point: A possible way of modulating tinnitus SO AUDIOLOGY AND NEURO-OTOLOGY LA English DT Article DE tinnitus; myofascial pain syndromes; diagnostic; skeletal muscle; upper extremity; laterality; case-control studies ID CHRONIC PAIN; MENIERES-DISEASE; MECHANISMS; MUSCLE; NEUROPLASTICITY; SYMPATHECTOMY; NECK AB In order to investigate whether myofascial trigger points can modulate tinnitus, as well as the association between tinnitus and myofascial trigger points, 94 individuals with and 94 without tinnitus, matched by age and gender, were analyzed by means of bilateral digital pressure of 9 muscles. Temporary modulation of tinnitus was frequently observed (55.9%) during digital pressure, mainly in the masseter. The rate of tinnitus modulation was significantly higher on the same side of the myofascial trigger point subject to examination in 6 out of 9 muscles. An association between tinnitus and the presence of myofascial trigger points was observed (p < 0.001), as well as a laterality association between the ear with the worst tinnitus and the side of the body with more myofascial trigger points (p < 0.001). Thus, this relationship could be explained not only by somatosensory-auditory system interactions but also by the influence of the sympathetic system. Copyright (c) 2007 S. Karger AG, Basel. C1 [Rocha, Carina A. C. Bezerra; Sanchez, Tanit Ganz] Univ Sao Paulo, Sch Med, Dept Otorhinolaryngol, BR-04530030 Sao Paulo, Brazil. [Rocha, Carina A. C. Bezerra; de Siqueira, Jose T. Tesseroli] Univ Sao Paulo, Dept Dent, BR-04530030 Sao Paulo, Brazil. RP Sanchez, TG (reprint author), Univ Sao Paulo, Sch Med, Dept Otorhinolaryngol, R Tenente Negrao 140-cj91, BR-04530030 Sao Paulo, Brazil. 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Neuro-Otol. PY 2008 VL 13 IS 3 BP 153 EP 160 DI 10.1159/000112423 PG 8 WC Audiology & Speech-Language Pathology; Neurosciences; Otorhinolaryngology SC Audiology & Speech-Language Pathology; Neurosciences & Neurology; Otorhinolaryngology GA 273ED UT WOS:000253912300002 ER PT J AU Titlic, M Tonkic, A Jukic, I Kolic, K Dolic, K AF Titlic, M. Tonkic, A. Jukic, I Kolic, K. Dolic, K. TI Clinical manifestations of vertebrobasilar dolichoectasia SO BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY LA English DT Review DE vertebrobasilar dolichoectasia; compression ID BASILAR ARTERY DOLICHOECTASIA; INTERNAL CAROTID-ARTERY; VERTEBRAL ARTERY; HEMIFACIAL SPASM; NERVE PALSY; STROKE; COMPRESSION; PATIENT; VERTIGO AB Vertebrobasilar dolichoectasia is defined as an increase in the length and diameter of the intracranial arteries. Clinical manifestations of dolichoectasiae result from compression of the cranial nerves and structures of the brain stem, turbulent flow causing tinnitus and vertigo, often with damages of small blood vessels of the brain. Dolichoectasia is an ishemic stroke risk factor. The role of dolichoectasia in occurrence of haemorrhagic stroke, aneurysm and arterial dissection and thrombosis is still not fully understood (Ref. 34). Full Text (Free, PDF) www.bmj.sk. C1 [Titlic, M.] Univ Hosp Split, Dept Neurol, Split 21000, Croatia. [Tonkic, A.; Jukic, I] Univ Hosp Split, Dept Internal Med, Split 21000, Croatia. [Kolic, K.; Dolic, K.] Univ Hosp Split, Dept Radiol, Split 21000, Croatia. RP Titlic, M (reprint author), Univ Hosp Split, Dept Neurol, Spinciceva 1, Split 21000, Croatia. 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Med. J. PY 2008 VL 109 IS 11 BP 528 EP 530 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA 401XL UT WOS:000262976200014 PM 19205567 ER PT J AU Couch, JR AF Couch, James R. TI Spontaneous intracranial hypotension: The syndrome and its complications SO CURRENT TREATMENT OPTIONS IN NEUROLOGY LA English DT Review ID CEREBROSPINAL-FLUID LEAKS; EPIDURAL BLOOD PATCH; CONNECTIVE-TISSUE; CSF LEAKS; HEADACHE; HYPOVOLEMIA; SPECTRUM; COMA; MRI AB Spontaneous intracranial hypotension (SIH) is a syndrome that was largely unknown until the advent of MRI. The incidence of SIH is estimated at 5 per 100,000, which is half the incidence of subarachnoid hemorrhage. The major feature is a postural headache of acute or subacute onset. This headache is absent or minimal when the patient is lying down and rapidly worsens to great intensity when the patient sits or stands. Other features may include nausea, vomiting, vertigo, tinnitus, and marked exacerbation by Valsalva maneuver. SIH is due to a leak of cerebrospinal fluid from a tear in the dural membrane, which occurs most often at the exit zones where the cervical spinal roots leave the subarachnoid space. Other leak sites may be the vestibular system, the cribriform plate, or the pituitary fossa. If the leak continues, the brain loses buoyancy within the cranial space and sags toward the foramen magnum. This, in turn, may produce subdural hygroma or hematoma, brainstem compression, focal cranial nerve palsies, or cerebellar tonsillar herniation. The initial therapy is generally strict bed rest. If this fails, an epidural blood patch is usually successful in sealing the leak and restoring brain buoyancy. A significant minority of patients require a repeat epidural blood patch. If the blood patch fails, a surgical approach may be needed. Repair of the leak and restoration of brain buoyancy will stop the postural headache and, in most cases, will reverse the complications. C1 Univ Oklahoma, Hlth Sci Ctr, Oklahoma City, OK 73104 USA. RP Couch, JR (reprint author), Univ Oklahoma, Hlth Sci Ctr, 711 Stanton L Young Blvd,Suite 215, Oklahoma City, OK 73104 USA. 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Treat. Options Neurol. PD JAN PY 2008 VL 10 IS 1 BP 3 EP 11 DI 10.1007/s11940-008-0001-5 PG 9 WC Clinical Neurology SC Neurosciences & Neurology GA 344CJ UT WOS:000258902900001 PM 18325294 ER PT J AU Verdel, BM van Puijenbroek, EP Souverein, PC Leufkens, HGM Egberts, ACG AF Verdel, Bertha Maria van Puijenbroek, Eugene P. Souverein, Patrick C. Leufkens, Hubert G. M. Egberts, Antoine C. G. TI Drug-Related Nephrotoxic and Ototoxic Reactions A Link through a Predictive Mechanistic Commonality SO DRUG SAFETY LA English DT Article ID STRIA VASCULARIS; ION-TRANSPORT; HAIR-CELLS; INNER-EAR; KIDNEY; CHANNELS; HEARING; K+; ABSORPTION; EPITHELIUM AB Background: Drug-induced ototoxicity is a subject of interest because many diseases are treated with drugs that have potential toxic effects oil the ear. There is evidence that both inner ear and kidney tissue are immunologically, biochemically and functionally related. It has been Suggested that drugs that influence the transport of sodium and/or potassium change ionic homeostasis in the inner ear and. hence. induce functional disturbances such as hearing loss, tinnitus and vertigo. Objectives: To assess whether renal Suspected adverse drug reactions (sADRs) have Predictive value for ear and labyrinth adverse drug reactions (ADRs) and whether drug classes involved have influence ion transport systems. Study design: Data were obtained front the Netherlands Pharmacovigilance Centre Lareb. The study base comprised all reports of sADRS up until 1 January 2007. Cases were all sADRs for relevant renal disorders and all sADRs for relevant ear disorders. All other reported sADRs were selected as 'non-cases'. The relationship between drug classes and renal, ear and labyrinth sADRs was evaluated by calculating reporting odds ratios (RORs). An ROR >= 1.50 was regarded as a cut-off value for an association. Drug classes were classified into four groups: (A) ROR kidney <1.50 and ROR ear <1.50 or no reports oil ear sADRs (reference group); (B) ROR kidney < 1.50 and ROR ear >= 1.50 (C) ROR kidney >= 1.50 and ROR ear <1.50 or no reports on ear sADRs and (D) ROR kidney ! 1.50 and ROR car ! 1.50. For each group, we calculated odds ratios (ORs) for the association between the group classification and the effect oil ion channels/ion transport systems in kidney and car tissues. Results: Of 193 drug classes with relevant ADRs for renal disorders, 120 drug classes also had reports oil ototoxic reactions. Fourteen out of 120 drug classes had an ROR >= 1.50 for the association between the drug class and both renal and ear sADRs. Among these drug classes were several with a well known abitity to induce renal (adverse) effects and ear and labyrinth disorders, Such as loop diuretics. aminoolycosides and quinine. We found that one mechanistic commonality of the drug classes mentioned in the reports was the ability to affect ion transport systems. The percentage of drugs having this property differed between the four groups. The ORs for groups D and B were significantly higher compared with the reference group (OR 12.2, 95% CI 3.0. 30.5 and OR 9.7, 95% CI 2.4, 18.7, respectively), whereas there was no association for group C. Conclusion: Our data suggest that renal sADRs as such are not a market for drug-induced car and labyrinth disorders. However, the ability of drugs to act on ion channels or ion transport systems and, therefore, have ail influence on ionic homeostasis in the kidney and car might be a predictor for the possible Occurrence of drug-related ototoxicity. C1 [Verdel, Bertha Maria; Souverein, Patrick C.; Leufkens, Hubert G. M.; Egberts, Antoine C. G.] Univ Utrecht, UIPS, Fac Sci, Utrecht, Netherlands. [van Puijenbroek, Eugene P.] Netherlands Pharmacovigilance Ctr Lareb, Shertogenbosch, Netherlands. [Egberts, Antoine C. G.] Univ Med Ctr Utrecht, Dept Clin Pharm, Utrecht, Netherlands. EM b.m.verdel@uu.nl CR ARNOLD W, 1984, ANN OTOL LARYNGOL, V112, pS119 Arslan E, 1999, ANN NY ACAD SCI, V884, P1 BLACK FO, 1993, OTOLARYNG CLIN N AM, V26, P713 *CDER, 2001, GUID IND S7A SAF PHA *CPMP, 2000, CPMPICH53900 CPMP (Committee for Proprietary Medicinal Products), 2000, CPMPSWP104299 CURTIS LM, 1993, EUR ARCH OTO-RHINO-L, V250, P265 De Bruin ML, 2005, EUR HEART J, V26, P590, DOI 10.1093/eurheartj/ehi092 Garcia VP, 2001, ACTA OTO-LARYNGOL, V121, P569, DOI 10.1080/000164801316878836 Hazell L, 2006, DRUG SAFETY, V29, P385, DOI 10.2165/00002018-200629050-00003 Herman P, 1997, AM J PHYSIOL-CELL PH, V272, pC184 Humes HD, 1999, ANN NY ACAD SCI, V884, P15 Hunter M, 2001, NATURE, V414, P502, DOI 10.1038/35107186 Ikeda K, 1997, HEARING RES, V107, P1, DOI 10.1016/S0378-5955(97)00009-9 Izzedine H, 2004, KIDNEY INT, V65, P369, DOI 10.1111/j.1523-1755.2004.00390.x Juhn S K, 2001, Int Tinnitus J, V7, P72 Lang F, 2007, AM J PHYSIOL-CELL PH, V293, pC1187, DOI 10.1152/ajpcell.00024.2007 Lee CA, 2005, J LARYNGOL OTOL, V119, P267 Lee JH, 2001, HEARING RES, V158, P123, DOI 10.1016/S0378-5955(01)00316-1 Liu JZ, 1996, ACTA OTO-LARYNGOL, V116, P572, DOI 10.3109/00016489609137891 LUMLEY C E, 1986, Pharmaceutical Medicine (London), V1, P205 Marcotti W, 2005, J PHYSIOL-LONDON, V567, P505, DOI 10.1113/jphysiol.2005.085951 Marcus DC, 1999, HEARING RES, V134, P48, DOI 10.1016/S0378-5955(99)00074-X Martin RM, 1998, BRIT MED J, V317, P119 Martini M, 2004, HEARING RES, V195, P67, DOI 10.1016/j.heares.2004.05.009 MILSTIEN JB, 1986, DRUG INF J, V20, P157 Peters TA, 2004, PEDIATR NEPHROL, V19, P1194, DOI 10.1007/s00467-004-1626-6 Pondugula SR, 2004, AM J PHYSIOL-RENAL, V286, pF1127, DOI 10.1152/ajprenal.00387.2003 PREPAGERAN N, 2004, OTOTOXICITY, P29 Seligmann H, 1996, DRUG SAFETY, V14, P198 STYPULKOWSKI PH, 1990, HEARING RES, V46, P113, DOI 10.1016/0378-5955(90)90144-E Takeuchi S, 1998, NEUROSCI LETT, V247, P175, DOI 10.1016/S0304-3940(98)00318-8 Thodi C, 2006, NEPHROL DIAL TRANSPL, V21, P3023, DOI 10.1093/ndt/gfl472 Tran Ba Huy Patrice, 2002, ORL J Otorhinolaryngol Relat Spec, V64, P120 van Puijenbroek EP, 2002, PHARMACOEPIDEM DR S, V11, P3, DOI 10.1002/pds.668 Vasquez Rachel, 2003, Ear Nose Throat J, V82, P181 WALKER EM, 1990, CLIN LAB MED, V10, P323 Wangemann P, 2006, J PHYSIOL-LONDON, V576, P11, DOI 10.1113/jphysiol.2006.112888 Wangemann P, 2002, AUDIOL NEURO-OTOL, V7, P199, DOI 10.1159/000063736 *WHO, 1994, AN THER CHEM ATC CLA NR 40 TC 2 Z9 2 PU ADIS INT LTD PI AUCKLAND PA 41 CENTORIAN DR, PRIVATE BAG 65901, MAIRANGI BAY, AUCKLAND 1311, NEW ZEALAND SN 0114-5916 J9 DRUG SAFETY JI Drug Saf. PY 2008 VL 31 IS 10 BP 877 EP 884 DI 10.2165/00002018-200831100-00006 PG 8 WC Public, Environmental & Occupational Health; Pharmacology & Pharmacy; Toxicology SC Public, Environmental & Occupational Health; Pharmacology & Pharmacy; Toxicology GA 354HN UT WOS:000259629700006 PM 18759511 ER PT J AU Lee, RE Balkany, TJ AF Lee, Raymond E. Balkany, Thomas J. TI Giant mastoid osteoma with postoperative, high-frequency sensorineural hearing loss SO ENT-EAR NOSE & THROAT JOURNAL LA English DT Article ID NOISE AB Osteomas occur throughout the temporal bone and, depending on their location, may cause tinnitus, hearing loss, vertigo, and facial nerve paresis. We present a rare case of a 25-year-old woman with a mastoid osteoma enlarging over a 6-month period. Other than a cosmetic deformity of her upper neck, the patient was asymptomatic. After surgical removal of the bony neoplasm, the patient was noted to have a high-frequency sensorineural hearing loss. This case study presents clinical, radiologic, intraoperative, pathologic, and audiometric findings of a mastoid osteoma and a review of the literature. C1 [Lee, Raymond E.; Balkany, Thomas J.] Univ Miami, Dept Otolaryngol Head & Neck Surg, Miami, FL 33136 USA. RP Balkany, TJ (reprint author), Univ Miami, Dept Otolaryngol Head & Neck Surg, 1666 NW 10th Ave,306, Miami, FL 33136 USA. EM tbalkany@miami.edu CR DENIA A, 1979, ARCH OTOLARYNGOL, V105, P706 GUPTA OP, 1972, LARYNGOSCOPE, V82, P172, DOI 10.1288/00005537-197202000-00003 KYLEN P, 1977, ACTA OTO-LARYNGOL, V84, P252, DOI 10.3109/00016487709123964 Marlowe F I, 1980, Am J Otolaryngol, V1, P191, DOI 10.1016/S0196-0709(80)80015-9 SUITS GW, 1993, OTOLARYNG HEAD NECK, V109, P660 NR 5 TC 1 Z9 1 PU VENDOME GROUP LLC PI NEW YORK PA 149 FIFTH AVE, 10TH FLOOR, NEW YORK, NY 10010 USA SN 0145-5613 J9 ENT-EAR NOSE THROAT JI ENT-Ear Nose Throat J. PD JAN PY 2008 VL 87 IS 1 BP 23 EP 25 PG 3 WC Otorhinolaryngology SC Otorhinolaryngology GA 257GR UT WOS:000252787700006 PM 18357940 ER PT J AU Topal, O Erbek, SS Erbek, S Ozluoglu, LN AF Topal, Ozgul Erbek, Selim S. Erbek, Seyra Ozluoglu, Levent N. TI Subjective pulsatile tinnitus associated with extensive pneumatization of temporal bone SO EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY LA English DT Article DE subjective pulsatile tinnitus; internal carotid artery; temporal bone AB Pulsatile tinnitus (PT), a rare otologic symptom, is frequently associated with identifiable and treatable causes. We report two cases of subjective PT due to extensive pneumatization of temporal bone around the internal carotid artery. C1 Baskent Univ, Konya Res & Teaching Ctr, Dept Otolaryngol, TR-42080 Konya, Turkey. Baskent Univ, Fac Med, Dept Otolaryngol, TR-06640 Ankara, Turkey. RP Topal, O (reprint author), Baskent Univ, Konya Res & Teaching Ctr, Dept Otolaryngol, Saray Caddesi No 1 Selcuklu, TR-42080 Konya, Turkey. EM ozgultopal75@yahoo.com CR HELLER A, 2003, OTOLARYNGOL CLIN N A, V6, P239 Koizuka Izumi, 1998, Auris Nasus Larynx, V25, P323, DOI 10.1016/S0385-8146(98)00016-9 SISMANIS A, 1994, AM J OTOL, V15, P404 Sismanis A, 1998, AM J OTOL, V19, P472 SISMANIS A, 1994, LARYNGOSCOPE, V104, P681 Tuz M, 2003, AURIS NASUS LARYNX, V30, P183, DOI 10.1016/S0385-8146(03)00002-6 Waldvogel D, 1998, J NEUROL, V245, P137, DOI 10.1007/s004150050193 Xenellis J, 2005, OTOL NEUROTOL, V26, P1149, DOI 10.1097/01.mao.0000194888.36400.d5 Yao WP, 1998, OTOLARYNG HEAD NECK, V118, P678, DOI 10.1177/019459989811800519 NR 9 TC 6 Z9 9 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013 USA SN 0937-4477 J9 EUR ARCH OTO-RHINO-L JI Eur. Arch. Oto-Rhino-Laryn. PD JAN PY 2008 VL 265 IS 1 BP 123 EP 125 DI 10.1007/s00405-007-0400-3 PG 3 WC Otorhinolaryngology SC Otorhinolaryngology GA 232HU UT WOS:000251010200018 PM 17647005 ER PT J AU Shore, SE Koehler, S Oldakowski, M Hughes, LF Syed, S AF Shore, S. E. Koehler, S. Oldakowski, M. Hughes, L. F. Syed, S. TI Dorsal cochlear nucleus responses to somatosensory stimulation are enhanced after noise-induced hearing loss SO EUROPEAN JOURNAL OF NEUROSCIENCE LA English DT Article DE auditory; multisensory neurons; neural pathways; neural plasticity; somatosensory tinnitus; trigeminal ID TRIGEMINAL GANGLION STIMULATION; AUDITORY ASSOCIATION CORTEX; SPONTANEOUS NEURAL ACTIVITY; SINGLE UNIT-ACTIVITY; GUINEA-PIG; ACOUSTIC TRAUMA; INDUCED HYPERACTIVITY; INFERIOR COLLICULUS; SUPERIOR COLLICULUS; DISCHARGE PATTERNS AB Multisensory neurons in the dorsal cochlear nucleus (DCN) achieve their bimodal response properties [Shore (2005) Eur. J. Neurosci., 21, 3334-3348] by integrating auditory input via VIIIth nerve fibers with somatosensory input via the axons of cochlear nucleus granule cells [Shore et al. (2000) J. Comp. Neurol., 419, 271-285; Zhou & Shore (2004) J. Neurosci. Res., 78, 901-907]. A unique feature of multisensory neurons is their propensity for receiving cross-modal compensation following sensory deprivation. Thus, we investigated the possibility that reduction of VIIIth nerve input to the cochlear nucleus results in trigeminal system compensation for the loss of auditory inputs. Responses of DCN neurons to trigeminal and bimodal (trigeminal plus acoustic) stimulation were compared in normal and noise-damaged guinea pigs. The guinea pigs with noise-induced hearing loss had significantly lower thresholds, shorter latencies and durations, and increased amplitudes of response to trigeminal stimulation than normal animals. Noise-damaged animals also showed a greater proportion of inhibitory and a smaller proportion of excitatory responses compared with normal. The number of cells exhibiting bimodal integration, as well as the degree of integration, was enhanced after noise damage. In accordance with the greater proportion of inhibitory responses, bimodal integration was entirely suppressive in the noise-damaged animals with no indication of the bimodal enhancement observed in a sub-set of normal DCN neurons. These results suggest that projections from the trigeminal system to the cochlear nucleus are increased and/or redistributed after hearing loss. Furthermore, the finding that only neurons activated by trigeminal stimulation showed increased spontaneous rates after cochlear damage suggests that somatosensory neurons may play a role in the pathogenesis of tinnitus. C1 [Shore, S. E.] Univ Michigan, Sch Med, Dept Mol & Integrat Physiol, Ann Arbor, MI 48109 USA. [Shore, S. E.; Koehler, S.] Univ Michigan, Sch Med, Dept Biomed Engn, Ann Arbor, MI 48109 USA. [Hughes, L. F.] So Illinois Univ, Sch Med, Dept Surg Otolaryngol, Springfield, IL USA. 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Evidence for the role of self-categorisation in symptom perceptions SO EUROPEAN JOURNAL OF SOCIAL PSYCHOLOGY LA English DT Article ID SOCIAL IDENTITY; ILLNESS REPRESENTATIONS; EXTERNAL INFORMATION; STRESS; PROTOTYPES; SEVERITY; SUPPORT; INJURY; FRAME; TASKS AB This paper extends the self-categorisation model of symptom appraisals to predict that individuals who believe they have a given illness will perceive concurrent symptoms relevant to that illness to be more severe when they categorise themselves as members of a group of people with that illness. These predictions are supported with opportunity samples of individuals reporting, or not reporting a common cold (Study 1, N = 60) and reporting colds or tinnitus (Study 2, N = 64). In both studies, relevant symptoms were rated as more severe when illness group memberships were salient. The methodological, theoretical and clinical implications of these findings and possible therapeutic applications of self-categorisation theory (SCT) to symptom perceptions are discussed. Copyright (c) 2007 John Wiley & Sons, Ltd. C1 [Claire, Lindsay St.; Clift, Alex; Dumbelton, Laura] Univ Bristol, Dept Expt Psychol, Bristol BS8 1TH, Avon, England. RP Claire, LS (reprint author), Sch Appl Community & Hlth, Ctr Hearing & Balance Studies, 5th Floor,F Block,8 Woodland Rd, Bristol BS8 1TN, Avon, England. 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TI Anatomic relationship between trigeminal nerve and temporomandibular joint SO EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES LA English DT Article DE trigeminal nerve; temporo-mandibular joint; relations; anatomic relations; pathologic relations; fresh cadavers dissection; temporo-mandibular disorders AB Temporomandibular joint disorders (TMD) is a collective term used to describe pathologic conditions involving temporomandibular joint (TMJ), masticatory muscles and associated structures. Common related complaints include local pain, limited mouth opening and TMJ noises whereas symptoms often associated to TMD with debated pathogenesis enclose earache, headaches, tinnitus and trigeminal-like symptoms such as atypical orofacial pain. In particular, TMD trigeminal associated symptoms are intricate, difficult to treat and exert a great impact on everyday life of the patients thus invoking a complex multidisciplinary treatment. In this paper, the authors analyze the anatomic and topographic relationships between the mandibular branch of the trigeminal nerve and the medial aspect of the TMJ capsule in 8 fresh adult cadavers thus resuming a pathologic relationship between atypical trigeminal symptoms and TMD. C1 [Paparo, F.; Fatone, F. M. G.; Ramieri, V.; Cascone, P.] Univ Roma La Sapienza, Cattedra Chirurg Maxillofacciale, Rome, Italy. RP Paparo, F (reprint author), Univ Roma La Sapienza, Cattedra Chirurg Maxillofacciale, Rome, Italy. EM Francesco.paparo@uniroma1.it RI ramieri, valerio/B-2543-2013 CR CASCONE P, 1990, DENT CADMOS, V58, P49 CASCONE P, 1944, DENT CADMOS, V58, P44 CASCONE P, 2004, PATOLOGIA ARTICOLAZI Costen JB, 1934, ANN OTO RHINOL LARYN, V43, P1 Davidson JA, 2003, J CRANIOFAC SURG, V14, P235, DOI 10.1097/00001665-200303000-00019 DIMOTROULIS G, 1998, BRIT MED J, V317, P190 Du Toit D F, 2003, SADJ, V58, P62 Farrar W B, 1971, N Y J Dent, V41, P348 Farrar WB, 1982, CLIN OUTLINE TEMPORO Kilpatrick SR, 2004, CRANIO, V22, P304 Lesch KP, 1996, SCIENCE, V274, P1527, DOI 10.1126/science.274.5292.1527 LOUGHNER BA, 1990, ORAL SURG ORAL MED O, V69, P299, DOI 10.1016/0030-4220(90)90290-9 Macfarlane TV, 2001, J DENT, V29, P451, DOI 10.1016/S0300-5712(01)00041-0 Salvinelli F, 2003, MED HYPOTHESES, V61, P446, DOI 10.1016/S0306-9877(03)00194-4 Schmidt BL, 1998, ORAL SURG ORAL MED O, V86, P165, DOI 10.1016/S1079-2104(98)90119-6 Shimokawa T, 2004, CLIN ANAT, V17, P2, DOI 10.1002/ca.10169 SICHER H, 1948, J AM DENT ASSOC, V36, P131 Speciali Jose Geraldo, 2005, Curr Pain Headache Rep, V9, P277, DOI 10.1007/s11916-005-0037-0 NR 18 TC 2 Z9 2 PU VERDUCI PUBLISHER PI ROME PA VIA GREGORIO VII, ROME, 186-00165, ITALY SN 1128-3602 J9 EUR REV MED PHARMACO JI Eur. Rev. Med. Pharmacol. Sci. PD JAN-FEB PY 2008 VL 12 IS 1 BP 15 EP 18 PG 4 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA 272DO UT WOS:000253839600003 PM 18401968 ER PT J AU Rubak, T Kock, S Koefoed-Nielsen, B Lund, SP Bonde, JP Kolstad, HA AF Rubak, Tine Kock, Samuel Koefoed-Nielsen, Birger Lund, Soren Peter Bonde, Jens Peter Kolstad, Henrik A. TI The risk of tinnitus following occupational noise exposure in workers with hearing loss or normal hearing SO INTERNATIONAL JOURNAL OF AUDIOLOGY LA English DT Article DE audiometry; epidemiology; hearing loss; noise induced; occupational exposure; occupational diseases; risk assessment ID ACUTE ACOUSTIC TRAUMA; PATHOPHYSIOLOGY; PREVALENCE; MECHANISMS AB The purpose was to investigate the relationship between noise exposure and tinnitus among workers with normal hearing and hearing loss, respectively. We conducted a cross-sectional survey of 752 workers employed at 91 workplaces, that were investigated by means of full work-shift noise levels, questionnaire data, and bilateral pure-tone audiometry. Tinnitus was not associated with the present noise level, the duration of noise exposure, or the cumulative noise exposure if participants had normal hearing. As expected, such trends were demonstrated if participants had a hearing handicap. Based on these data, we will be cautious in ascribing tinnitus to noise exposure in our patients' workplaces if they have a normal audiogram. Furthermore our data indicates no risk of noise-induced tinnitus at exposure levels where no hearing loss would be expected, e.g. as usually encountered in non-industrial workplaces. C1 [Rubak, Tine; Kock, Samuel; Bonde, Jens Peter; Kolstad, Henrik A.] Aarhus Univ Hosp, Dept Occupat Med, DK-8000 Aarhus, Denmark. [Koefoed-Nielsen, Birger] Aarhus Univ Hosp, Dept Audiol, DK-8000 Aarhus, Denmark. [Lund, Soren Peter] Natl Inst Occupat Hlth, Copenhagen, Denmark. RP Kolstad, HA (reprint author), Aarhus Univ Hosp, Dept Occupat Med, Norrebrogade 44, DK-8000 Aarhus, Denmark. EM hkols@as.aaa.dk RI Legarth, Jonas/A-9156-2012 CR ALBERTI PW, 1987, J OTOLARYNGOL, V16, P34 [Anonymous], 1990, 1999 ISO *ARB, 2003, ANM ARB ARS 2002 Armstrong BG, 1998, OCCUP ENVIRON MED, V55, P651 AXELSSON A, 1989, British Journal of Audiology, V23, P53, DOI 10.3109/03005368909077819 AXELSSON A, 1985, British Journal of Audiology, V19, P271, DOI 10.3109/03005368509078983 Axelsson A, 2000, NOISE HEALTH, V2, P47 Axelsson A., 1992, NOISE INDUCED HEARIN, P269 Baguley DM, 2002, BRIT MED BULL, V63, P195, DOI 10.1093/bmb/63.1.195 CAHANI M, 1983, AUDIOLOGY, V22, P357 CHUNG DY, 1984, AUDIOLOGY, V23, P441 Coles RRA, 1981, CIBA F S, V85, P16 EGGERMONT JJ, 1990, HEARING RES, V48, P111, DOI 10.1016/0378-5955(90)90202-Z Griest S E, 1998, AAOHN J, V46, P325 JASTREBOFF PJ, 1990, NEUROSCI RES, V8, P221, DOI 10.1016/0168-0102(90)90031-9 Kock S, 2004, OCCUP ENVIRON MED, V61, P838, DOI 10.1136/oem.2004.012757 LEPAGE EL, 1995, MECH TINNITUS, P115 Lockwood AH, 2002, NEW ENGL J MED, V347, P904, DOI 10.1056/NEJMra013395 Malchaire J, 1997, ANN OCCUP HYG, V41, P467, DOI 10.1016/S0003-4878(97)00007-0 MAN A, 1981, AUDIOLOGY, V20, P72 MCSHANE DP, 1988, CLIN OTOLARYNGOL, V13, P323, DOI 10.1111/j.1365-2273.1988.tb00760.x Meikle M, 1984, J Laryngol Otol Suppl, V9, P17 Moller AR, 2003, OTOLARYNG CLIN N AM, V36, P249, DOI 10.1016/S003-6665(02)00170-6 Mrena R, 2004, INT J AUDIOL, V43, P177, DOI 10.1080/14992020400050025 Mrena R, 2002, AUDIOL NEURO-OTOL, V7, P122, DOI 10.1159/000057660 Neitzel R, 1999, AM IND HYG ASSOC J, V60, P807 Nottet JB, 2006, LARYNGOSCOPE, V116, P970, DOI 10.1097/01.MLG.0000216823.77995.13 Palmer KT, 2002, OCCUP ENVIRON MED, V59, P634, DOI 10.1136/oem.59.9.634 PHOON WH, 1993, OCCUP MED-OXFORD, V43, P35, DOI 10.1093/occmed/43.1.35 Sallustio V, 1998, SCAND AUDIOL, V27, P95 Savastano M, 2004, J OTOLARYNGOL, V33, P248, DOI 10.2310/7070.2004.03057 Sindhusake Doungkamol, 2004, J Am Acad Audiol, V15, P269 Sindhusake D, 2003, EAR HEARING, V24, P501, DOI 10.1097/01.AUD.0000100204.08771.3D STOUFFER JL, 1990, J SPEECH HEAR DISORD, V55, P439 Sułkowski W, 1999, Int J Occup Med Environ Health, V12, P177 Temmel AFP, 1999, WIEN KLIN WOCHENSCHR, V111, P891 NR 36 TC 7 Z9 8 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 1499-2027 J9 INT J AUDIOL JI Int. J. Audiol. PY 2008 VL 47 IS 3 BP 109 EP 114 DI 10.1080/14992020701581430 PG 6 WC Audiology & Speech-Language Pathology; Otorhinolaryngology SC Audiology & Speech-Language Pathology; Otorhinolaryngology GA 269MV UT WOS:000253654000003 PM 18307090 ER PT J AU Sakata, T Esaki, Y Yamano, T Sueta, N Nakagawa, T AF Sakata, Toshifumi Esaki, Yoshito Yamano, Takafumi Sueta, Naoyuki Nakagawa, Takashi TI A comparison between the feeling of ear fullness and tinnitus in acute sensorineural hearing loss SO INTERNATIONAL JOURNAL OF AUDIOLOGY LA English DT Article; Proceedings Paper CT 28th International Congress of Audiology CY SEP 03-07, 2006 CL Innsbruck, AUSTRIA DE feeling of ear fullness; tinnitus; sudden deafness; sensorineural hearing loss AB The feeling of ear fullness (FEF) occurs frequently in patients with acute sensorineural hearing loss; the same is true for tinnitus (TIN). However, the cause of FEF in these patients is unclear. This study included 171 ears of patients admitted with unilateral sudden deafness to the ENT division of Fukuoka University Hospital between January 2001 and December 2004. The results showed TIN was mainly associated with worse high-frequency hearing thresholds, where hearing loss was relatively severe, and this association became stronger after the hearing threshold stabilized. FEF was associated with the low-frequency region, where hearing loss was relatively mild, and this association disappeared after the hearing threshold stabilized. In conclusion, TIN is thought to originate in the region where hair cells are impaired; in contrast, FEF may originate from some functional factor rather than an organic lesion of the cochlea. C1 [Sakata, Toshifumi; Esaki, Yoshito; Yamano, Takafumi; Sueta, Naoyuki; Nakagawa, Takashi] Fukuoka Univ, Sch Med, Dept Otorhinolaryngol, Jonan Ku, Fukuoka 8140180, Japan. RP Sakata, T (reprint author), Fukuoka Univ, Sch Med, Dept Otorhinolaryngol, Jonan Ku, Nanakuma 7-45-1, Fukuoka 8140180, Japan. EM sakata@fukuoka-u.ac.jp CR DANINO J, 1984, AM J OTOLARYNG, V5, P394, DOI 10.1016/S0196-0709(84)80054-X Eggermont JJ, 2003, AURIS NASUS LARYNX S, V30, P7, DOI 10.1016/S0385-8146(02)00122-0 GERALD EM, 1980, LARYNGOSCOPE, V90, P853 Gorga M P, 1991, J Am Acad Audiol, V2, P1 Henry JA, 1999, P 6 INT TINN SEM, P51 HORNER KC, 1991, HEARING RES, V52, P147, DOI 10.1016/0378-5955(91)90194-E JASTREBOFF PJ, 1990, NEUROSCI RES, V8, P221, DOI 10.1016/0168-0102(90)90031-9 Kiang NY, 1970, SENSORINEURAL HEARIN, P241 Konig O, 2006, HEARING RES, V221, P59, DOI 10.1016/j.heares.2006.07.007 Mamak Aydin, 2005, Ear Nose Throat J, V84, P641 Rask-Andersen H, 1999, Rev Laryngol Otol Rhinol (Bord), V120, P203 SHUNICHI I, 1997, ANN OTO RHINOL LARYN, V106, P746 Tokumasu K, 1996, ACTA OTO-LARYNGOL, P43 TONNDORF J, 1962, ANN OTO RHINOL LARYN, V71, P5 TONO T, 1995, AUDIOLOGY, V34, P47 Westerlaken BO, 2003, ANN OTO RHINOL LARYN, V112, P993 NR 16 TC 3 Z9 6 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 1499-2027 J9 INT J AUDIOL JI Int. J. Audiol. PY 2008 VL 47 IS 3 BP 134 EP 140 DI 10.1080/14992020701760547 PG 7 WC Audiology & Speech-Language Pathology; Otorhinolaryngology SC Audiology & Speech-Language Pathology; Otorhinolaryngology GA 269MV UT WOS:000253654000006 PM 18307093 ER PT J AU Brannstrom, KJ Grenner, J AF Brannstrom, K. Jonas Grenner, Jan TI Clinical application of long-term intensity and pitch matches in fluctuating low-frequency hearing loss SO INTERNATIONAL JOURNAL OF AUDIOLOGY LA English DT Article DE long-term measurement; binaural intensity matches; binaural pitch matches; home audiometry; fluctuating hearing loss; low-frequency hearing loss; 2AFC; disease activity ID TUNING CURVES; DEAD REGIONS; DIPLACUSIS; PERCEPTION; ANOMALIES; EARS AB The purpose of this study was to measure changes in intensity and pitch matches to better assess disease activity in fluctuating hearing loss. Long-term suprathreshold audiometry was carried out at home on a subject with a unilateral fluctuating low-frequency hearing loss during a period when the subject demonstrated no symptoms and a period when the subject reported hearing loss, aural pressure, and tinnitus. Daily measurements of binaural intensity and pitch matches were made. Day-to-day fluctuations were clearly accentuated during the period when the subject experienced symptoms. Specifically, deviations from the reference tone were only observed for binaural pitch matches at 1 kHz during the period without symptoms; however, highly fluctuating binaural intensity and pitch matches were observed at 0.25 kHz during the period with symptoms. These fluctuations were not observed in a normal-hearing group. The results suggest that long-term measurements of binaural intensity and pitch matches can be used to monitor disease activity in fluctuating low-frequency hearing loss. C1 [Brannstrom, K. Jonas] Malmo Univ Hosp, Dept Audiol, SE-20502 Malmo, Sweden. [Brannstrom, K. Jonas; Grenner, Jan] Lund Univ, Dept Clin Sci, S-22100 Lund, Sweden. [Grenner, Jan] Lund Univ, Dept Audiol, S-22100 Lund, Sweden. RP Brannstrom, KJ (reprint author), Malmo Univ Hosp, Dept Audiol, SE-20502 Malmo, Sweden. EM jonas.brannstrom@med.lu.se CR ALBERS GD, 1968, ARCH OTOLARYNGOL, V87, P601 ALBERS GD, 1968, ARCH OTOLARYNGOL, V87, P607 ALBERS GD, 1968, ARCH OTOLARYNGOL, V87, P604 ALLEN GW, 1983, OTOLARYNG CLIN N AM, V16, P3 [Anonymous], 2004, 3898 ISO 8, P389 [Anonymous], 1995, OTOLARYNGOL HEAD NEC, V113, P181 BRANNSTROM J, 2008, INT J AUDIOL, V47, P59 BROOKES GB, 1995, MENIERES DIS, P157 BURNS EM, 1986, J ACOUST SOC AM, V79, P1530, DOI 10.1121/1.393679 BURNS EM, 1982, J ACOUST SOC AM, V72, P1394, DOI 10.1121/1.388445 FLORENTINE M, 1983, J ACOUST SOC AM, V73, P961, DOI 10.1121/1.389021 HINCHCLIFFE R, 2003, TXB AUDIOLOGICAL MED, P579 Huss M, 2005, J ACOUST SOC AM, V117, P3841, DOI 10.1121/1.1920167 *IEC, 1998, 603181 IEC 1 *IEC, 1998, 603182 IEC 2 KIMURA RS, 1995, MENIERES DIS, P93 Knight RD, 2004, INT J AUDIOL, V43, P45, DOI 10.1080/14992020400050007 MARTINI A, 2003, TXB AUDIOLOGICAL MED, P451 Moore B., 1998, COCHLEAR HEARING LOS Moore BCJ, 2001, EAR HEARING, V22, P268, DOI 10.1097/00003446-200108000-00002 Ogura M, 2003, INT J AUDIOL, V42, P297, DOI 10.3109/14992020309101321 Paparella M M, 1990, J Vestib Res, V1, P3 Takeshima H, 2001, ACUSTICA, V87, P389 TONNDORF J, 1976, ARCH OTO-RHINO-LARYN, V212, P293, DOI 10.1007/BF00453677 TURNER C, 1983, J ACOUST SOC AM, V73, P966, DOI 10.1121/1.389022 VANDENABEELE D, 1992, SCAND AUDIOL, V21, P3 Xenellis JE, 2004, LARYNGOSCOPE, V114, P1953, DOI 10.1097/01.mlg.0000147927.98766.e1 NR 27 TC 0 Z9 0 PU INFORMA HEALTHCARE PI LONDON PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND SN 1499-2027 J9 INT J AUDIOL JI Int. J. Audiol. PY 2008 VL 47 IS 7 BP 412 EP 419 DI 10.1080/14992020801991729 PG 8 WC Audiology & Speech-Language Pathology; Otorhinolaryngology SC Audiology & Speech-Language Pathology; Otorhinolaryngology GA 317JS UT WOS:000257016700003 ER PT J AU Brunnberg, E Linden-Bostrom, M Berglund, M AF Brunnberg, Elinor Linden-Bostrom, Margareta Berglund, Mats TI Tinnitus and hearing loss in 15-16-year-old students: Mental health symptoms, substance use, and exposure in school SO INTERNATIONAL JOURNAL OF AUDIOLOGY LA English DT Article DE Adolescents; Bullied; Hearing disability; Gender; Mental health; Substance use; Tinnitus ID SOCIAL-RESEARCH; CHILDHOOD; CHILDREN; COHERENCE; SENSE AB The current study assessed the responses from a survey titled 'Life and Health - Young People 2005', completed by 2878 15-16-year-old adolescents in mainstream schools in the county of Orebro, Sweden. Thirty-nine percent of students with hearing loss (slight, mild, or moderate) and 6% of students with normal hearing reported tinnitus often or always during the past three months. Almost no gender difference was observed among students with normal-hearing reporting tinnitus (boys 6.3%, girls 5.6%); however, a gender difference was noticed among hard-of-hearing (HH) students (boys 50%, girls 28%). Adolescents with both hearing loss and tinnitus reported considerably higher scores for mental health symptoms, substance use, and school problems than other students. Anxiety in the past three months, male gender, and alcohol consumption in the past year were associated with tinnitus in HH students; irritation and anxiety in the past three months, disability, use of illicit drugs, and truancy predicted tinnitus in the normal-hearing group. Consequently, students with a hearing loss and tinnitus are at high risk and should be monitored for subsequent problems. C1 [Brunnberg, Elinor] Univ Orebro, Dept Behav Social & Legal Sci, S-70182 Orebro, Sweden. [Linden-Bostrom, Margareta] Orebro Cty Council, Dept Community Med & Publ Hlth, Orebro, Sweden. [Berglund, Mats] Lund Univ, S-22100 Lund, Sweden. RP Brunnberg, E (reprint author), Univ Orebro, Dept Behav Social & Legal Sci, S-70182 Orebro, Sweden. 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G., 2006, USING MULTIVARIATE S, V5th WILSON PH, 1998, INT TINNITUS J, V4, P25 NR 26 TC 7 Z9 7 PU INFORMA HEALTHCARE PI LONDON PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND SN 1499-2027 J9 INT J AUDIOL JI Int. J. Audiol. PY 2008 VL 47 IS 11 BP 688 EP 694 DI 10.1080/14992020802233915 PG 7 WC Audiology & Speech-Language Pathology; Otorhinolaryngology SC Audiology & Speech-Language Pathology; Otorhinolaryngology GA 376GO UT WOS:000261172300002 PM 19031227 ER PT J AU Andersson, G Westin, V AF Andersson, Gerhard Westin, Vendela TI Understanding tinnitus distress: Introducing the concepts of moderators and mediators SO INTERNATIONAL JOURNAL OF AUDIOLOGY LA English DT Article; Proceedings Paper CT International Conference on From Signal to Dialogue - Dynamic Aspects of Hearing, Language and Cognition CY SEP 07-08, 2007 CL Linkoping, SWEDEN HO Linkoping Univ DE Tinnitus; Behavioural measures; Psycho-social; emotional; Psychoacoustics; hearing science ID SAMPLE FEEDBACK TECHNIQUE; SELF-CONTROL; FOLLOW-UP; ATTENTION; CONSEQUENCES; COMPLAINTS; DISORDERS; ANNOYANCE; SUFFERERS; COGNITION AB We focus this theoretical paper on a neglected distinction in tinnitus research between moderators and mediators of tinnitus distress. A moderator variable is one that influences the strength of a relationship between two other variables. In the paper we propose that several variables might act as moderators of tinnitus distress. Degree of hearing loss, arousal, insomnia, characteristics of tinnitus, noise sensitivity, and a range of psychological factors such as personality and perceived control are discussed as potential moderators. We then move on to mediator variables. A mediator variable is one that explains the relationship between the two other variables, and must by definition be caused by a predictor, and then mediate between the predictor and the dependent variable. We propose that stress levels (caused by tinnitus), classical conditioning, selective attention towards tinnitus, and psychological acceptance of tinnitus (versus experiential avoidance) might be mediators of distress. We encourage more research on moderators and mediators of tinnitus distress, as these will help illuminate treatment protocols and how they might work. C1 [Andersson, Gerhard; Westin, Vendela] Linkoping Univ, Dept Behav Sci & Learning, SE-58183 Linkoping, Sweden. [Andersson, Gerhard; Westin, Vendela] Swedish Inst Disabil Res, Linkoping, Sweden. [Andersson, Gerhard; Westin, Vendela] Linkoping Univ Hosp, Dept Audiol, S-58185 Linkoping, Sweden. [Andersson, Gerhard] Karolinska Inst, Dept Clin Neurosci, Psychiat Sect, Stockholm, Sweden. RP Andersson, G (reprint author), Linkoping Univ, Dept Behav Sci & Learning, SE-58183 Linkoping, Sweden. 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PY 2008 VL 47 SU 2 BP S106 EP S111 DI 10.1080/14992020802301670 PG 6 WC Audiology & Speech-Language Pathology; Otorhinolaryngology SC Audiology & Speech-Language Pathology; Otorhinolaryngology GA 372NT UT WOS:000260909000014 PM 19012118 ER PT J AU Westin, V Ostergren, R Andersson, G AF Westin, Vendela Ostergren, Richard Andersson, Gerhard TI The effects of acceptance versus thought suppression for dealing with the intrusiveness of tinnitus SO INTERNATIONAL JOURNAL OF AUDIOLOGY LA English DT Article; Proceedings Paper CT International Conference on From Signal to Dialogue - Dynamic Aspects of Hearing, Language and Cognition CY SEP 07-08, 2007 CL Linkoping, SWEDEN HO Linkoping Univ DE Tinnitus; Acceptance; Thought suppression ID CHRONIC PAIN; HOSPITAL ANXIETY; DEPRESSION SCALE; THERAPY; SAMPLE AB The purpose of this study was to examine the effect of acceptance versus suppression of disruptions on a mental imagery task in a sample of tinnitus patients. Previous research has indicated that acceptance can be an effective strategy for dealing with unpleasant experiences such as pain and anxiety. The study used a between-group design, including 47 participants who completed a task involving mental imagery in a sound-proof booth. Participants were randomly assigned to three instruction conditions: acceptance, suppression, or a control condition. The results showed a significant difference between the acceptance group and the control group in that participants in the acceptance group were able to focus on the imagery task for a longer time without being interrupted. The study provides preliminary support for the notion that acceptance can be a helpful strategy for tinnitus patients. C1 [Westin, Vendela; Ostergren, Richard; Andersson, Gerhard] Linkoping Univ, Dept Behav Sci & Learning, SE-58183 Linkoping, Sweden. [Andersson, Gerhard] Swedish Inst Disabil Res, Linkoping, Sweden. [Andersson, Gerhard] Karolinska Inst, Dept Clin Neurosci, Psychiat Sect, Stockholm, Sweden. [Andersson, Gerhard] Linkoping Univ Hosp, Dept Audiol, S-58185 Linkoping, Sweden. RP Andersson, G (reprint author), Linkoping Univ, Dept Behav Sci & Learning, SE-58183 Linkoping, Sweden. EM Gerhard.Andersson@liu.se RI Andersson, Gerhard/J-8529-2012 OI Andersson, Gerhard/0000-0003-4753-6745 CR Abramowitz JS, 2001, CLIN PSYCHOL REV, V21, P683, DOI 10.1016/S0272-7358(00)00057-X ABROMOWITZ JS, 2001, CLIN PSYCHOL REV, V21, P685 Andersson G, 1999, BRIT J AUDIOL, V33, P201 Andersson G, 2006, ACTA OTO-LARYNGOL, V126, P39, DOI 10.1080/03655230600895226 ANDERSSON G, 2002, P 7 INT TINN SEM FRE, P197 Andersson G, 2002, CLIN PSYCHOL REV, V22, P977, DOI 10.1016/S0272-7358(01)00124-6 Andersson G, 2003, J PSYCHOSOM RES, V55, P259, DOI 10.1016/S0022-3999(02)00575-5 Andersson G, 2004, AUDIOL MED, V2, P54, DOI 10.1080/16513860410027358 Andersson G., 2006, TINNITUS TREATMENT C, P96 Andersson G., 2005, TINNITUS MULTIDISCIP Andersson G, 2006, AUDIOL NEURO-OTOL, V11, P301, DOI 10.1159/000094460 Baguley D M, 2003, Am J Audiol, V12, P31, DOI 10.1044/1059-0889(2003/007) Clark DM, 2004, BEHAV RES THER, V42, P1089, DOI 10.1016/j.brat.2004.05.002 Dobie RA, 1999, LARYNGOSCOPE, V109, P1202, DOI 10.1097/00005537-199908000-00004 Eifert GH, 2003, J BEHAV THER EXP PSY, V34, P293, DOI 10.1016/j.jbtep.2003.11.001 Erlandsson S, 2000, TINNITUS HDB, P25 Gutierrez O, 2004, BEHAV THER, V35, P767, DOI 10.1016/S0005-7894(04)80019-4 Harvey A. 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TI Multifaceted therapeutic benefits of Ginkgo biloba L.: Chemistry, efficacy, safety, and uses SO JOURNAL OF FOOD SCIENCE LA English DT Review DE flavonoids; Ginkgo biloba; Ginkgo leaf extract; neuroprotective terpenoids ID EXTRACT EGB 761; RANDOMIZED CLINICAL-TRIAL; PLACEBO-CONTROLLED TRIAL; ST-JOHNS-WORT; ALZHEIMERS-DISEASE; ALTERNATIVE MEDICINE; DOUBLE-BLIND; BENZODIAZEPINE-RECEPTOR; MOLECULAR-MECHANISMS; MEMORY IMPAIRMENT AB The new age of nutraceuticals is now embracing the centuries old herbal extract of Ginkgo biloba (Mantissa Plantarum Altera, 1771, Ginkgoceae). The standardized preparation of the Ginkgo leaf extract (EGb 761) contained 2 main bioactive constituents, flavonoid glycosides (24%) and terpene lactones (6%), along with less than 5 ppm of the allergenic component, ginkgolic acid. The Ginkgo leaf extract has been reported to have neuroprotective, anticancer, cardioprotective, stress alleviating, and memory enhancing effects and possible effects on tinnitus, geriatric complaints, and psychiatric disorders. The therapeutic mechanisms of action of the Ginkgo leaf extract are suggested to be through its antioxidant, antiplatelet, antihypoxic, antiedemic, hemorrheologic, and microcirculatory actions, where the flavonoid and the terpenoid constituents may act in a complementary manner. Toxicity studies show that the Ginkgo leaf extract is relatively safe for consumption, although a few side effects have been reported, that is, intracerbral hemorrhage, gastrointestinal disturbances, headaches, dizziness, and allergic skin reactions. The use of Ginkgo leaf extract may be promising for treatment of certain conditions, although its long-term use still needs to be evaluated. C1 [Mahadevan, S.; Park, Y.] Univ Massachusetts, Dept Food Sci, Amherst, MA 01003 USA. RP Park, Y (reprint author), Univ Massachusetts, Dept Food Sci, 100 Holdsworth Way, Amherst, MA 01003 USA. 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Food Sci. PD JAN-FEB PY 2008 VL 73 IS 1 BP R14 EP R19 DI 10.1111/j.1750-3841.2007.00597.x PG 6 WC Food Science & Technology SC Food Science & Technology GA 255OF UT WOS:000252666600003 PM 18211362 ER PT J AU Sadlier, M Stephens, SDG Kennedy, V AF Sadlier, M. Stephens, S. D. G. Kennedy, V. TI Tinnitus rehabilitation: a mindfulness meditation cognitive behavioural therapy approach SO JOURNAL OF LARYNGOLOGY AND OTOLOGY LA English DT Article DE tinnitus; cognitive therapy; meditation ID STRESS REDUCTION; PSYCHOLOGICAL TREATMENT; RELAXATION RESPONSE; CONTROLLED TRIAL; CHRONIC PAIN; MANAGEMENT; DEPRESSION; HEALTH; OUTPATIENTS; PREVENTION AB Background: Chronic tinnitus is a frequent symptom presentation in clinical practice. No drug treatment to date has shown itself to be effective. The aim of the present study was to investigate the effects of cognitive behavioural therapy and meditation in tinnitus sufferers. Methodology: Patients were selected from a dedicated tinnitus clinic in the Welsh Hearing Institute. A waiting list control design was used. Twenty-five chronic tinnitus sufferers were consecutively allocated to two groups, one receiving a cognitive behavioural therapy/meditation intervention of four one hour sessions with the other group waiting three months and subsequently treated in the same way, thereby acting as their own control. The main outcome was measured using the Hallam tinnitus questionnaire. A four to six month follow up was conducted. Results: These showed significant statistical reductions in tinnitus variables both in the active and also in the control group. Post-therapy, no significant change was found after the waiting list period. The improvement was maintained at the four to six month period. Conclusion: The positive findings give support for the use of cognitive behavioural therapy/meditation for chronic tinnitus sufferers. 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Laryngol. Otol. PD JAN PY 2008 VL 122 IS 1 BP 31 EP 37 DI 10.1017/S0022215107007438 PG 7 WC Otorhinolaryngology SC Otorhinolaryngology GA 258JQ UT WOS:000252864600007 PM 17451612 ER PT J AU Pedersen, CS Moller, H Waye, KP AF Pedersen, Christian Sejer Moller, Henrik Waye, Kerstin Persson TI A detailed study of low-frequency noise complaints SO JOURNAL OF LOW FREQUENCY NOISE VIBRATION AND ACTIVE CONTROL LA English DT Article ID FLUCTUATING HEARING-LOSS; LABYRINTHINE VERTIGO; MENIERES-DISEASE; PURE-TONES; TINNITUS; ANNOYANCE; PATHOPHYSIOLOGY; RECOMMENDATIONS; INFRASOUND; MANAGEMENT AB From 203 cases of low-frequency complaints a random selection of twenty-one cases were investigated. The main aim was to answer the question whether the annoyance is caused by an external physical sound or by a perceived but physically non-existing sound, i.e. low-frequency tinnitus. Noise recordings were made in the homes of the complainants, and the complainants were exposed to these in blind test listening experiments. Furthermore, the low-frequency hearing function of the complainants was investigated, and characteristics of the annoying sound were matched. The results showed that some of the complainants are annoyed by a physical sound (20-180 Hz), while others suffer from low-frequency tinnitus (perceived frequency 40-100 Hz). Physical sound at frequencies below 20 Hz (infrasound) is not responsible for the annoyance or at all audible - in any of the investigated cases, and none of the complainants has extraordinary hearing sensitivity at low frequencies. For comparable cases of low-frequency noise complaints in general, it is anticipated that physical sound is responsible in a substantial part of the cases, while low-frequency tinnitus is responsible in another substantial part of the cases. C1 [Pedersen, Christian Sejer; Moller, Henrik; Waye, Kerstin Persson] Univ Aalborg, Sect Acoust, Dept Elect Syst, Aalborg, Denmark. RP Pedersen, CS (reprint author), Univ Aalborg, Sect Acoust, Dept Elect Syst, Aalborg, Denmark. 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N., 1977, Applied Acoustics, V10, DOI 10.1016/0003-682X(77)90007-X VASUDEVAN RN, 1982, J LOW FREQ NOISE VIB, V1, P157 Vasudevan R. N., 1989, Journal of Low Frequency Noise & Vibration, V8 Vercammen M. L. S., 1992, Journal of Low Frequency Noise & Vibration, V11 Vesterager V, 1997, BRIT MED J, V314, P728 Waddington D, 2007, J LOW FREQ NOISE V A, V26, P155, DOI 10.1260/026309207783700411 Walford R. E., 1983, J LOW FREQ NOISE VIB, V2, P60 WATANABE T, 2004, 11 INT M LOW FREQ NO, P377 WAYE KP, 2006, INTER NOISE YAMADA S, 1980, C LOW FREQ NOIS HEAR, V55, P814 YAMADA S, 1982, J LOW FREQ NOISE VIB, V1, P19 2002, UNTERSUCHUNG BRUMMTO, P1 NR 84 TC 7 Z9 7 PU MULTI SCIENCE PUBL CO LTD PI BRENTWOOD PA 5 WATES WAY, BRENTWOOD CM15 9TB, ESSEX, ENGLAND SN 0263-0923 J9 J LOW FREQ NOISE V A JI J. Low Freq. Noise Vib. Act. Control PY 2008 VL 27 IS 1 BP 1 EP 33 DI 10.1260/026309208784425505 PG 33 WC Acoustics SC Acoustics GA 306UJ UT WOS:000256273000001 ER PT J AU Leventhall, G Benton, S Robertson, D AF Leventhall, Geoff Benton, Stephen Robertson, Donald TI Coping strategies for low frequency noise SO JOURNAL OF LOW FREQUENCY NOISE VIBRATION AND ACTIVE CONTROL LA English DT Article AB A small group (n=9), whose complaints of low frequency noise had not been resolved by Environmental Health Officers and related care professionals, were invited to attend a series of intervention sessions led by a psychotherapist. The aims of the sessions were to improve the participants' coping strategies and their quality of life, in order to relieve them from some of the distress caused by their belief that they were exposed to low frequency noise. Prior to the psychotherapy sessions the group was evaluated on a number of self report questionnaires, which measured individual responses for reaction to low frequency noise, quality of life, quality of coping and a personality questionnaire (Insights(tm) Discovery Preference Evaluator). A before and after, within group analysis of responses was based upon repeat measures of the three behavioural response questionnaires for noise reactivity, quality of life and coping. A general reduction in the subjects' stress levels was shown, suggesting positive effects of psychotherapy upon symptoms that had, in this group's case, proved resistant to improvement by conventional local authority and specialist interventions. This 'therapeutic' approach to LFN interventions could lead to improved health and effectiveness and fewer demands oil local services. Although the techniques of tinnitus management were informative, analogy between the problems of low frequency noise sufferers and those of tinnitus sufferers fails at the point where low frequency noise sufferers believe that an external agency is the cause of their problems. C1 [Benton, Stephen] Univ Westminster, Dept Psychol, London W1R 8AL, England. RP Leventhall, G (reprint author), 150 Craddocks Ave, Surrey KT21 1NL, England. EM geoff@activenoise.co.uk CR Beck A., 1976, COGNITIVE THERAPY EM BELOJEVIC G, 2003, NOISE HLTH, V6, P67 BENSON H, 1996, WELLNESS BOOK COMPRE Benson H., 1975, RELAXATION RESPONSE *BMA, 2002, ILL MED DICT Colman A., 2001, OXFORD DICT PSYCHOL Leventhall H. G., 2003, REV PUBLISHED RES LO Vickers A, 1999, BRIT MED J, V319, P1346 WILKINSON G, 2004, UNDERSTANDING STRESS WILSON PH, 1991, J SPEECH HEAR RES, V34, P197 NR 10 TC 6 Z9 6 PU MULTI SCIENCE PUBL CO LTD PI BRENTWOOD PA 5 WATES WAY, BRENTWOOD CM15 9TB, ESSEX, ENGLAND SN 0263-0923 J9 J LOW FREQ NOISE V A JI J. Low Freq. Noise Vib. Act. Control PY 2008 VL 27 IS 1 BP 35 EP 52 DI 10.1260/026309208784425460 PG 18 WC Acoustics SC Acoustics GA 306UJ UT WOS:000256273000002 ER PT J AU Kendall, CJ Rosenheck, R AF Kendall, Caroline J. Rosenheck, Robert TI Use of mental health services by veterans disabled by auditory disorders SO JOURNAL OF REHABILITATION RESEARCH AND DEVELOPMENT LA English DT Article DE auditory disorder; disability; health services use; hearing loss; mental health; psychiatric disorder; rehabilitation; tinnitus; VA; veterans ID HEARING-LOSS; ADULTS; DEAF; IMPACT; CARE AB This study examined whether veterans disabled by auditory disorders face barriers to receipt of Department of Veterans Affairs (VA) mental health services. We compared use of VA mental health services by veterans disabled by auditory disorders with use of such services by veterans disabled by four other chronic illnesses. We hypothesized that disabled veterans with auditory disorders, including tinnitus and/or hearing loss, would be less likely to use VA mental health services than other disabled veterans because of communication difficulties. The study sample was based oil national VA administrative data for veterans with a diagnosed mental health disorder who were not receiving VA compensation for that disorder but who were receiving VA compensation for another disorder, either physical or auditory, at the end of fiscal year 2005. After controlling for potentially confounding factors, We unexpectedly found that veterans disabled by auditory disorders were more likely than other disabled veterans to use VA mental health services at least once. Among users, however, those with auditory disorders accessed slightly fewer visits than those disabled by other conditions, although the reasons for the difference remain unclear. C1 [Kendall, Caroline J.] VA Connecticut Healthcare Syst, Psychol Serv 116B, Dept Vet Affairs, West Haven, CT 06516 USA. [Kendall, Caroline J.; Rosenheck, Robert] Yale Univ, Dept Psychiat, New Haven, CT 06520 USA. [Rosenheck, Robert] VA New England Mental Illness Res Educ & Clin Ctr, West Haven, CT USA. [Rosenheck, Robert] Yale Univ, Sch Publ Hlth & Epidemiol, New Haven, CT USA. RP Kendall, CJ (reprint author), VA Connecticut Healthcare Syst, Psychol Serv 116B, Dept Vet Affairs, 950 Campbell Ave,Bldg 8, West Haven, CT 06516 USA. EM caroline.kendall@va.gov CR Barnett S, 2002, HEALTH SERV RES, V37, P105 Collins JG, 1997, VITAL HLTH STAT, V10, P1 Dalton DS, 2003, GERONTOLOGIST, V43, P661 Fagelson Marc A, 2007, Am J Audiol, V16, P107, DOI 10.1044/1059-0889(2007/015) Green CA, 2001, J AGING HEALTH, V13, P315, DOI 10.1177/089826430101300301 Henry J. L., 2001, PSYCHOL MANAGEMENT C Henry JA, 2007, TINNITUS RETRAINING Hoff RA, 1998, MED CARE, V36, P1524, DOI 10.1097/00005650-199811000-00002 Hoffmann H. J., 2004, TINNITUS THEORY MANA, P16 Jastreboff PJ, 2004, TINNITUS THEORY MANA, P8 KNUTSON JF, 1990, J SPEECH HEAR DISORD, V55, P656 Lethbridge-Cejku M, 2004, VITAL HLTH STAT, V10, P1 Martinez Devesa P., 2007, COCHRANE DB SYST REV, DOI DOI 10.1002/14651858.CD005233.PUB2 Mitchell RE, 2006, J DEAF STUD DEAF EDU, V11, P112, DOI 10.1093/deafed/enj004 Mrena R, 2002, AUDIOL NEURO-OTOL, V7, P122, DOI 10.1159/000057660 POLLARD RQ, 1994, REHABIL PSYCHOL, V39, P147, DOI 10.1037//0090-5550.39.3.147 Ries P. W., 1994, VITAL HLTH STAT, V10, P1 Schaller S., 1991, MAN WORDS TYEMURRAY N, 2004, FDN AURAL REHABILITA, P41 Unutzer J, 2006, PSYCHIAT SERV, V57, P37, DOI 10.1176/appi.ps.57.1.37 VERBRUGGE LM, 1995, AM J PUBLIC HEALTH, V85, P173, DOI 10.2105/AJPH.85.2.173 *VET BEN ADM, 2006, ANN BEN REP FISC YEA NR 22 TC 1 Z9 1 PU JOURNAL REHAB RES & DEV PI BALTIMORE PA DEPT OF VETERANS AFFAIRS REHABIL RES & DEVELOP CTR 103 SOUTH GAY STREET, BALTIMORE, MD 21202-4051 USA SN 0748-7711 J9 J REHABIL RES DEV JI J. Rehabil. Res. Dev. PY 2008 VL 45 IS 9 BP 1349 EP 1360 DI 10.1682/JRRD.2007.11.0185 PG 12 WC Rehabilitation SC Rehabilitation GA 426RN UT WOS:000264725500013 PM 19319759 ER PT J AU Nakagawa, M Miyachi, N Fujiwara, K AF Nakagawa, Minoru Miyachi, Norimitsu Fujiwara, Kenjiro TI A convenient sonographic technique for diagnosis of pulsatile tinnitus induced by a high jugular bulb SO JOURNAL OF ULTRASOUND IN MEDICINE LA English DT Article DE brain; high jugular bulb; pulsatile; sonography; tinnitus AB Objective. The purpose of this report is to describe our experience with sonography in a case of pulsatile tinnitus (PT) due to a high jugular bulb (HJB). Methods. A 71-year-old woman came to our hospital with a 1-year history of right PT A right HJB was shown on cerebral angiography, and enlargement of the right jugular blub compared with the left side was found. First, the ultrasound probe was placed on the anterior right upper neck at the anterior edge of the sternocleidomastoid muscle to identify the ipsilateral internal jugular vein (IJV) and measure the flow velocity. After the measurement, the ultrasound probe gradually compressed the skin until the flow in the IN decreased. Results. The patient reported that her PT decreased after the flow in the IN decreased. We decided that the PT in this case was induced by the HJB. Conclusions. This technique is less invasive and convenient for the diagnosis of PT caused by an HJB. C1 [Nakagawa, Minoru; Fujiwara, Kenjiro] Kosei Gen Hosp, Dept Neurosurg, Hiroshima 7238686, Japan. [Miyachi, Norimitsu] Kosei Gen Hosp, Clin Lab, Hiroshima 7238686, Japan. RP Nakagawa, M (reprint author), Kosei Gen Hosp, Dept Neurosurg, 3-3-28 Minami, Hiroshima 7238686, Japan. EM ydhm18357@yahoo.co.jp CR Sonmez G, 2007, CLIN IMAG, V31, P102, DOI 10.1016/j.clinimag.2006.12.024 NR 1 TC 2 Z9 3 PU AMER INST ULTRASOUND MEDICINE PI LAUREL PA SUBSCRIPTION DEPT, 14750 SWEITZER LANE, STE 100, LAUREL, MD 20707-5906 USA SN 0278-4297 J9 J ULTRAS MED JI J. Ultrasound Med. PD JAN PY 2008 VL 27 IS 1 BP 139 EP 140 PG 2 WC Acoustics; Radiology, Nuclear Medicine & Medical Imaging SC Acoustics; Radiology, Nuclear Medicine & Medical Imaging GA 249AJ UT WOS:000252198600016 PM 18096739 ER PT J AU Westermann, DH Schefer, H Thalmann, GN Karamitopoulou-Diamantis, E Fey, MF Studer, UE AF Westermann, Dirk H. Schefer, Hubert Thalmann, George N. Karamitopoulou-Diamantis, Evanthia Fey, Martin F. Studer, Urs E. TI Long-term followup results of 1 cycle of adjuvant bleomycin, etoposide and cisplatin chemotherapy for high risk clinical stage I nonseminomatous germ cell tumors of the testis SO JOURNAL OF UROLOGY LA English DT Article DE testis; neoplasms; germ cell and embryonal; testicular neoplasms; chemotherapy ID LYMPH-NODE DISSECTION; EMBRYONAL CARCINOMA; TESTICULAR CANCER; VASCULAR INVASION; 2 CYCLES; SURVEILLANCE AB Purpose: We evaluated the long-term outcome after I cycle of adjuvant modified bleomycin, etoposide and cisplatin chemotherapy in patients who underwent orchiectomy for high risk clinical stage I nonseminomatous germ cell tumor of the testis. Materials and Methods: Between 1995 and 1999 a consecutive series of 44 patients underwent orchiectomy for clinical stage I nonseminomatous germ cell tumor of the testis, followed by a single postoperative cycle of adjuvant modified bleomycin, etoposide and cisplatin for vascular or lymphatic tumor invasion, and/or a predominance (50% or greater) of embryonal carcinoma. Results: Four of the 44 patients were excluded from analysis. Of the patients 35 had no evidence of disease at a median followup of 99 months (range 60 to 134). One patient with progression after 13 months showed complete remission after 3 cycles of salvage bleomycin, etoposide and cisplatin chemotherapy but he died of pneumonia 4 weeks after the third course. Two patients underwent orchiectomy for contralateral testis cancer at 18 and 42 months, respectively, followed by an additional 3 cycles of adjuvant chemotherapy. They remained relapse-free for 4 and 92 months, respectively. The former patient was lost to followup after 4 months. Two other patients were disease-free at 10 and 31 months, respectively, and were lost to followup thereafter. Late side effects were tinnitus in 3 patients and involuntary childlessness in 3, of whom 2 had cryptorchidism of the contralateral testis. Nine patients fathered children. Conclusions: One cycle of bleomycin, etoposide and cisplatin effectively decreases the risk of relapse in patients with high risk stage I nonseminomatous germ cell tumor of the testis. It has minimal side effects and can be a valuable alternative to retroperitoneal lymph node dissection. C1 [Westermann, Dirk H.; Thalmann, George N.; Studer, Urs E.] Univ Hosp Bern, Dept Urol, CH-3010 Bern, Switzerland. [Schefer, Hubert; Fey, Martin F.] Univ Hosp Bern, Dept Med Oncol, CH-3010 Bern, Switzerland. [Karamitopoulou-Diamantis, Evanthia] Univ Hosp Bern, Dept Pathol, CH-3010 Bern, Switzerland. RP Studer, UE (reprint author), Univ Hosp Bern, Dept Urol, CH-3010 Bern, Switzerland. EM urology_berne@insel.ch RI Schefer, Jurg/G-3960-2012 CR ALBERS P, 2006, J CLIN ONCOL, V24, P4512 Al-Tourah AJ, 2005, J UROLOGY, V174, P2209, DOI 10.1097/ju.0000181810.22617.f8 Bohlen D, 2001, J UROLOGY, V165, P441, DOI 10.1097/00005392-200102000-00022 Bohlen D, 1999, J UROLOGY, V161, P1148, DOI 10.1016/S0022-5347(01)61615-X Chevreau C, 2004, EUR UROL, V46, P209, DOI 10.1016/j.euruo.2004.03.022 DONOHUE JP, 1995, EUR J CANCER, V31A, P1599, DOI 10.1016/0959-8049(95)00330-L Ernst D Scott, 2005, Can J Urol, V12, P2575 Gilbert DC, 2006, BJU INT, V98, P67, DOI 10.1111/j.1464-410X.2006.06188.x Heidenreich A, 1998, CANCER, V83, P1002, DOI 10.1002/(SICI)1097-0142(19980901)83:5<1002::AID-CNCR27>3.0.CO;2-A Hermans BP, 2000, J UROLOGY, V163, P1721, DOI 10.1016/S0022-5347(05)67528-3 MOUL JW, 1994, CANCER RES, V54, P362 Oliver RTD, 2004, UROLOGY, V63, P556, DOI 10.1016/j.urology.2003.10.023 Pont J, 1996, J CLIN ONCOL, V14, P441 Roeleveld TA, 2001, J UROLOGY, V166, P2166, DOI 10.1016/S0022-5347(05)65527-9 Schmoll HJ, 2004, ANN ONCOL, V15, P1377, DOI 10.1093/annonc/mdh301 Sheinfeld J, 2003, J UROLOGY, V170, P1159, DOI 10.1097/01.ju.0000087822.71739.9a Stephenson AJ, 2005, J CLIN ONCOL, V23, P2781, DOI 10.1200/JCO.2005.07.132 Sweeney CJ, 2000, J CLIN ONCOL, V18, P358 NR 18 TC 28 Z9 28 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0022-5347 J9 J UROLOGY JI J. Urol. PD JAN PY 2008 VL 179 IS 1 BP 163 EP 166 DI 10.1016/j.juro.2007.08.172 PG 4 WC Urology & Nephrology SC Urology & Nephrology GA 241IN UT WOS:000251650200046 PM 18001800 ER PT J AU Pirodda, A Esposti, DD Brandolini, C Modugno, GC Cosentino, E Borghi, C AF Pirodda, Antonio Esposti, Daniela Degli Brandolini, Cristina Modugno, Giovanni Carlo Cosentino, Eugenio Borghi, Claudio TI Could echocardiography yield a cardiovascular profile of the tinnitus prone subject? SO MEDICAL HYPOTHESES LA English DT Article ID LEFT-VENTRICULAR MASS; SENSORINEURAL HEARING-LOSS; HYPOTENSION; HYPERTENSION AB The possible genesis of some damage of the inner ear from a hemodynamic imbalance of functional origin, possibly linked to hypotension followed by an abnormal vasomotor regulatory activity, has been pointed out by our group over the years. As tinnitus, which is often referable to an inner ear origin, can represent a signal of incoming sufferance of the organ of Corti and may not necessarily be linked to hearing impairment, it seemed of some utility to investigate on the prevalence of tinnitus under various well monitored hemodynamic conditions. This led to observe that the prevalence of this symptom, regardless of audiological features, was increased under "aggressive" anti hypertensive therapy as well as in particularly severe degree of heart decompensation. These data represent a first step and encourage in searching for a profile of subject who could be more prone to the development of tinnitus with respect to the normal population, even in absence of pathological conditions. With this aim, echocardiography is thought to be able to yield useful informations in addition to standard and ambulatory blood pressure monitoring, in order to obtain a better definition of the correlations between cardiovascular function (and related changes) and inner ear insufficient perfusion. (C) 2007 Elsevier Ltd. All rights reserved. C1 [Pirodda, Antonio; Brandolini, Cristina; Modugno, Giovanni Carlo] Univ Bologna, Dept Surg & Anaesthesiol Sci, I-40126 Bologna, Italy. [Esposti, Daniela Degli; Cosentino, Eugenio; Borghi, Claudio] Univ Bologna, Dept Internal Med, I-40126 Bologna, Italy. RP Modugno, GC (reprint author), Univ Bologna, Dept Surg & Anaesthesiol Sci, I-40126 Bologna, Italy. EM giovanni.modugno@unibo.it CR Borghi C, 2005, CURR THER RES CLIN E, V66, P420, DOI 10.1016/j.curtheres.2005.10.001 Borghi C, 2000, AM J OBSTET GYNECOL, V183, P140, DOI 10.1016/S0002-9378(00)24854-0 Borghi C, 2006, MED HYPOTHESES, V67, P437, DOI 10.1016/j.mehy.2006.01.061 Celentano A, 2001, AM J CARDIOL, V87, P361, DOI 10.1016/S0002-9149(00)01379-5 COSENTINO ER, 2006, IPERTENSIONE PREVENZ, V13, P173 de Simone G, 1998, HYPERTENSION, V31, P1077 de Simone G, 2001, J HYPERTENS, V19, P119, DOI 10.1097/00004872-200101000-00016 Muiesan ML, 2006, J HYPERTENS, V24, P2293, DOI 10.1097/01.hjh.0000249709.44016.15 Mureddu GF, 2001, J HYPERTENS, V19, P1113 Pirodda A, 1997, MED HYPOTHESES, V48, P195, DOI 10.1016/S0306-9877(97)90304-2 Pirodda A, 2001, ARCH OTOLARYNGOL, V127, P1049 Pirodda A, 1997, AUDIOLOGY, V36, P98 Pirodda A, 2004, J LARYNGOL OTOL, V118, P941 Pirodda A, 1999, ACTA OTO-LARYNGOL, V119, P758 Romano C, 2003, AM J CLIN NUTR, V77, P308 Sanchez L, 2004, AUDIOL MED, V2, P8, DOI 10.1080/16513860410027781 TUNGLAND OP, 2004, AUDIOLOGIC MED, V2, P18, DOI 10.1080/16513860410027402 2005, EUR HEART J NR 18 TC 5 Z9 6 PU CHURCHILL LIVINGSTONE PI EDINBURGH PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE, LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND SN 0306-9877 J9 MED HYPOTHESES JI Med. Hypotheses PY 2008 VL 70 IS 2 BP 252 EP 254 DI 10.1016/j.mehy.2006.12.068 PG 3 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA 258WT UT WOS:000252901500008 PM 17709211 ER PT J AU Kosma, KK Kararizou, E Markou, I Eforakopoulou, E Kararizos, G Mitsonis, C Gkiatas, K AF Kosma, Katerina K. Kararizou, Evangelia Markou, Ioannis Eforakopoulou, Evanthia Kararizos, Grigoris Mitsonis, Charalampos Gkiatas, Konstantinos TI Headache as a first manifestation of Vogt-Koyanagi-Harada disease SO MEDICAL PRINCIPLES AND PRACTICE LA English DT Article DE Vogt-Koyanagi-Harada disease; headache; veitis AB Objectives: To describe headache as an initial presentation of Vogt-Koyanagi-Harada (VKH) disease. Clinical Presentation and Intervention: A 56-year-old man initially presented with a 6-month duration of a continuous, diffuse headache of mild to moderate and sometimes of severe intensity. ACT of the brain was normal. Neurological examination was normal, including absence of symptoms and signs of meningismus. During the last 2 months, an intermittent eye pain, redness, and gradual loss of vision in both eyes was detected and subsequently he had tinnitus, malaise, nausea and mild meningismus. He was diagnosed as having VKH disease. Ophthalmologic examination revealed high intraocular pressure, requiring trabeculectomy with surgical iridectomy. The patient is now being treated with systemic steroids. Conclusion: VKH disease may initially present as sustained headache, without specific ophthalmologic symptoms and it should be considered in the differential diagnosis in patients with atypical but relentless headache. Copyright (C) 2008 S. Karger AG, Basel. C1 [Kosma, Katerina K.; Kararizou, Evangelia; Mitsonis, Charalampos] Univ Athens, Aeginit Hosp, Dept Neurol, Athens, Greece. [Markou, Ioannis; Eforakopoulou, Evanthia; Kararizos, Grigoris; Gkiatas, Konstantinos] 251 Hellen AF Gen Hosp, Athens, Greece. RP Kararizou, E (reprint author), Aeginit Hosp, Neurol Clin, 72-74 Vass Sofias Ave, GR-11528 Athens, Greece. EM ekarariz@med.uoa.gr CR Andreoli Christopher M., 2006, International Ophthalmology Clinics, V46, P111, DOI 10.1097/00004397-200604620-00011 BENIZ J, 1991, RETINA-J RET VIT DIS, V11, P275, DOI 10.1097/00006982-199111030-00001 MOORTHY RS, 1995, SURV OPHTHALMOL, V39, P265, DOI 10.1016/S0039-6257(05)80105-5 Nomura S, 1998, BLOOD, V91, P3616 Read RW, 2001, AM J OPHTHALMOL, V131, P647, DOI 10.1016/S0002-9394(01)00925-4 SVITRA PP, 1994, PRINCIPLES PRACTICE, V1, P481 Yamaki Kunihiko, 2002, International Ophthalmology Clinics, V42, P13 NR 7 TC 2 Z9 2 PU KARGER PI BASEL PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND SN 1011-7571 J9 MED PRIN PRACT JI Med. Princ. Pract. PY 2008 VL 17 IS 3 BP 253 EP 254 DI 10.1159/000117802 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA 287CN UT WOS:000254894400014 PM 18408397 ER PT J AU Senkal, HA Ozkan, S Oguz, KK Turan, E AF Senkal, Hilmi Alper Ozkan, Soner Oguz, Kader Karli Turan, Ergin TI Dolichoectatic and tortuous vertebrobasillary arterial system causing progressive left-sided hearing loss in a patient with previous right-sided deafness SO MEDITERRANEAN JOURNAL OF OTOLOGY LA English DT Article ID BASILAR ARTERY; ANEURYSM; FUSIFORM AB Giant dolichoectatic aneurysms in the vertebrobasilar system are rare. They usually manifest themselves when they compress the brainstem or cranial nerves, or when they are complicated by intraluminal thrombi or dissection. A 63-year-old man presented with a 6-month history of progressive left-sided hearing loss and tinnitus, in addition to having hearing loss in the right ear since childhood. In audiological assessment total hearing loss was present in the right ear, while a mild degree of sensorineural hearing loss was noted in the left ear, especially at high frequencies. Speech discrimination was lower than normal, which was inconsistent with the degree of measured hearing loss, suggesting retrocochlear pathology. The tone decay test was positive for the left ear. All these findings, including an auditory brainstem response test, suggested the existence of retrocochlear pathology on the left side. Temporal-cranial MRI and cerebral angiography revealed a dolichoectatic basillar artery aneurysm that was compressing brainstem and bilateral tortuous dolichoectatic vertebral arteries compressing the root entry zones of the 7-8(th) cranial nerves. No surgical or vascular interventional treatment was recommended because of the high risk of complication based on the location of the lesion. After 1 year of anti-aggregant and anti hypertensive treatment, audiological tests revealed total hearing loss in the left ear. Anti-aggregant and antihypertensive treatment was continued. C1 [Senkal, Hilmi Alper; Turan, Ergin] Hacettepe Univ, Fac Med, Dept Otorhinolaryngol Head & Neck Surg, TR-06100 Ankara, Turkey. [Oguz, Kader Karli] Hacettepe Univ, Fac Med, Dept Radiol, TR-06100 Ankara, Turkey. [Ozkan, Soner] Hacettepe Univ, Fac Med, Dept Sect Audiol & Speech Pathol, TR-06100 Ankara, Turkey. RP Senkal, HA (reprint author), Hacettepe Univ, Fac Med, Dept Otorhinolaryngol Head & Neck Surg, TR-06100 Ankara, Turkey. EM dralpersenkal@yahoo.com CR Boardman P, 1998, BRIT J RADIOL, V71, P332 Büttner U, 1995, J Vestib Res, V5, P47 Cosetti M, 2007, LARYNGOSCOPE, V117, P35, DOI 10.1097/01.mlg.0000246695.16366.c5 Dziewas R, 2003, EUR NEUROL, V49, P245, DOI 10.1159/000070196 Flemming KD, 2004, J NEUROSURG, V101, P82, DOI 10.3171/jns.2004.101.1.0082 Nakatomi H, 2000, STROKE, V31, P896 Passero SG, 2005, STROKE, V36, P1421, DOI 10.1161/01.STR.0000172311.64662.9c Sarkar A, 2004, SKULL BASE-INTERD AP, V14, P101, DOI 10.1055/s-2004-828703 SARKAR A, 2004, SKULL BASE, V14, P106 Vieco PT, 1997, AM J NEURORADIOL, V18, P1385 Welsh LW, 2000, ANN OTO RHINOL LARYN, V109, P615 NR 11 TC 0 Z9 0 PU MEDITERRANEAN SOC OTOLOGY & AUDIOLOGY PI ANKARA PA SELANIK CADDESI 48, 3 KIZILAY, ANKARA, 00000, TURKEY SN 1305-5267 J9 MEDITERR J OTOL JI Mediterr. J. Otol. PY 2008 VL 4 IS 2 BP 143 EP 147 PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA 349SH UT WOS:000259303100012 ER PT J AU Ferraz, S AF Ferraz, Silvio TI TWO PIECES BY RODOLFO CAESAR TINNITUS (2004) E BIO-ACUSTICA (2005) SO MUSICA HODIE LA Portuguese DT Article DE Musical analysis; Musique acousmatique; Rodolfo Caesar; "Ecoute"; Pierre Schaeffer AB This paper presents an analytical reading of Tinnitus and Bio-acustica, two acousmatic compositions of Rodolfo Cesar. It speculates also a musical analysis way for acousmatic music (music heard through loudspeakers). The main focus is the presence of daily sounds in both compositions, and the use of this aspect to construct an analytical typology of sound objects which explains those pieces ir his gradual sonic transformations. The main concepts for this analysis are found in Pierre Schaeffer's idea of sonic objects and "ecoute". Our main objective concerns to uses a more descriptive way of analysis in consonance with the compositional procedures used in both pieces. C1 [Ferraz, Silvio] IA UNICAMP, Dept Mus, Campinas, Brazil. [Ferraz, Silvio] Univ Estadual Campinas, Nucleo Integracao & Difusao Cultural, Campinas, Brazil. RP Ferraz, S (reprint author), IA UNICAMP, Dept Mus, Campinas, Brazil. EM silvio.ferraz@terra.com.br CR BANDEIRA M, ITINERARIO PASARGADA, P51 CAESAR C, 2004, CONFLUENCIA TINNITUS DEANTONIO MM, 2001, CORRES M DEANDROBE M DELEUZE C, 2001, EMPIRISMO SUBJETIVID, P12 MANUEL B, 1958, POESIA PROSA, P51 NIETZSCHE F, 2004, AURORA SAO PAULO COM, P171 NR 6 TC 0 Z9 0 PU UNIV FEDERAL GOIAS PI GOIANIA GO PA ESCOLA MUSICA ARTES CIENCIAS, PROG POT-GRAD MUSICA, CAIXA POSTAL 131, CAMPUS II-SAMAMBAIA, GOIANIA GO, CEP74001-970, BRAZIL SN 1676-3939 J9 MUSICA HODIE JI Musica Hodie PY 2008 VL 8 IS 1 BP 87 EP 98 PG 12 WC Music SC Music GA 473UW UT WOS:000268236100007 ER PT J AU Sun, YF Dai, GH Yuan, J Zhai, WD Zhong, JW Wang, T AF Sun, Yongfeng Dai, Guanghui Yuan, Jun Zhai, Weidong Zhong, Jianwei Wang, Tao TI Complications of microvascular decompression in hemifacial spasm treatment - Retrospective analysis of 156 cases SO NEURAL REGENERATION RESEARCH LA English DT Article DE microvascular decompression; hemifacial spasm; postoperative complication ID RATES AB BACKGROUND: Microvascular decompression has become a well-accepted, safe method in the treatment of hemifacial spasms. However, postoperative complications exist and influence the prognosis of the disease. OBJECTIVE: This study aimed to analyze, by case review, the characteristics and regularity of microvascular decompression complications in the treatment of hemifacial spasm. DESIGN: Retrospective analysis. SETTING: Beijing General Group Hospital of the Chinese People's Armed Police Forces. PARTICIPANTS: A total of 156 patients with hemifacial spasm were admitted to the Department of Neurosurgery. Beijing General Group Hospital of the Chinese People's Armed Police Forces from June 2004 to June 2006 and recruited for this study. The patients, 57 males and 99 females, averaged 46 years of age (range 17-68-years old). All Suffered from facial innervated muscular paroxysmal and recurrent contraction, which could not be controlled by consciousness. Electromyogram demonstrated waves of fibrillation and fasciculation. Prior to admission, all patients had received other treatments. Written informed consents for treatment were obtained from all patients. This protocol was approved by the Hospital's Ethics Committee. METHODS: After anesthesia. a cranial bone pore was drilled below the connection of the lateral sinus and sigmoid sinus. Dura mater was dissected at the "perpendicular to" shape and held in the air. Under microscopy, the flocculus cerebelli was lifted slightly up for convenient observation of the cerebellopontine angle. The mucous membrane was,as sharply separated. Corresponding vessels were identified at the root of the facial nerves and subsequently liberated and disassociated from the root exit zone. Suitably sized Teflon cotton was placed between the corresponding vessels and brain stem. MAIN OUTCOME MEASURES: Complications of microvascular decompression. RESULTS: All 156 patients participated in the final analysis. (1) Postoperatively, 66 (42%) patients presented with obvious headache or dizziness, 5 (3%) with severe headache, 43 (28%) with nausea or vomiting for 12 hours to 3 days. and 19 (12%) with aseptic meningitis and a body temperature of 37.5-40 degrees C. Patients. who suffered from headache and fever, were cured after 2-5 lumbar punctures. (2) Postoperatively, 19 (8%) patients suffered from, short-term dysaudia and tinnitus on the affected side, 9 (6%) from mild hemifacial spasms, and 2 (1%) from ambiopia. All patients were cured after treatment with a neurotrophic drug. (3) Postoperatively, 4 (2%) patients suffered from cerebrospinal fluid incision leakage and 2 (1%) from cerebrospinal rhinorrhea. The cerebrospinal fluid incision was tightly sutured. One case of cerebrospinal rhinorrhea was cured after mastoid process repair, and the other one recovered spontaneously. CONCLUSION: Experimental results have indicated that low intracranial pressure is the main complication of microvascular decompression in patients with hemifacial spasms, and no permanent neuro-functional impairment was found. C1 [Sun, Yongfeng; Dai, Guanghui; Yuan, Jun; Zhai, Weidong; Zhong, Jianwei; Wang, Tao] Chinese Peoples Armed Police Forces, Dept Neurosurg, Beijing Gen Grp Hosp, Beijing 100027, Peoples R China. RP Sun, YF (reprint author), Chinese Peoples Armed Police Forces, Dept Neurosurg, Beijing Gen Grp Hosp, Beijing 100027, Peoples R China. EM sunyongfeng666@126.com CR BALIAZIN VA, 2003, ZH VOPR NEIROKHIR N, V4, P6 Kalkanis SN, 2003, NEUROSURGERY, V52, P1251, DOI 10.1227/01.NEU.0000065129.25359 LIANG WB, 2005, LITI DINGXIANG HE GO, V18, P16 [梁维邦 Liang Weibang], 2002, [江苏医药, Jiangsu medical Journal], V28, P329 LIU DZ, 1999, LITI DINGXIANG HE GO, V12, P36 Malliti M, 2004, NEUROSURGERY, V54, P599, DOI 10.1227/01.NEU.0000108640.45371.1A McLaughlin MR, 1999, J NEUROSURG, V90, P1, DOI 10.3171/jns.1999.90.1.0001 Payner TD, 1996, NEUROSURGERY, V38, P686 Wang AC, 1998, MUSCLE NERVE, V21, P1740, DOI 10.1002/(SICI)1097-4598(199812)21:12<1740::AID-MUS17>3.0.CO;2-V WANG RZ, 2002, NEUROSURGERY, P358 Yamada K, 2002, J NEUROSURG, V96, P731, DOI 10.3171/jns.2002.96.4.0731 YU H, 2003, ZHONGGUO WEIQINGXI S, V8, P469 NR 12 TC 0 Z9 0 PU SHENYANG EDITORIAL DEPT NEURAL REGENERATION RES PI SHENYANG PA PO BOX 1234, SHENYANG, LIAONING 110004, PEOPLES R CHINA SN 1673-5374 J9 NEURAL REGEN RES JI Neural Regen. Res. PD JAN PY 2008 VL 3 IS 1 BP 101 EP 103 PG 3 WC Cell Biology; Neurosciences SC Cell Biology; Neurosciences & Neurology GA 344JH UT WOS:000258922300024 ER PT J AU White, JB Kaufmann, TJ Kallmes, DF AF White, James Bradley Kaufmann, Timothy J. Kallmes, David F. TI Venous sinus thrombosis: A misdiagnosis using MR angiography SO NEUROCRITICAL CARE LA English DT Article DE magnetic resonance angiography; digital subtraction angiography; venous sinus thrombosis ID VENOGRAPHY AB Introduction Magnetic resonance venography (MRV) is a non-invasive imaging modality that is used in many centers to supplant conventional cerebral digital subtraction angiography (DSA) for the diagnosis of dural venous sinus thrombosis. Discussion We present the case of a pregnant female diagnosed with dural venous sinus thrombosis by serial time-of-flight (TOF) MRV examinations, and treated with long-term anticoagulation based on these examinations. Results The appearance of the affected dural sinus did not change on MRV over the treatment period. The patient returned during follow-up with new-onset pulsatile tinnitus, which prompted us to perform DSA to exclude a dural arteriovenous fistula. DSA revealed that the segment of venous sinus diagnosed as thrombosed on MRV actually was patent but had a septation in its midsection. Conclusions We concluded that the patient did not have a venous sinus thrombosis at the time of MRV examinations but rather an anatomical variant mimicking a thrombosis, which would not have required any treatment. MRV, particularly TOF MRV, is limited by artifacts in correctly identifying vascular anatomy and pathology and should be interpreted carefully. DSA remains the reference standard for most vascular imaging. C1 [Kaufmann, Timothy J.; Kallmes, David F.] Mayo Clin, Dept Radiol, Rochester, MN 55905 USA. [White, James Bradley] Mayo Clin, Dept Clin Neurol, Rochester, MN USA. RP Kallmes, DF (reprint author), Mayo Clin, Dept Radiol, 200 1st St SW, Rochester, MN 55905 USA. EM kallmes.david@mayo.edu CR Elster A. D., 2001, QUESTIONS ANSWERS MA Kallmes DF, 1998, NEURORADIOLOGY, V40, P242 Leach JL, 2007, AM J NEURORADIOL, V28, P782 Shellock FG, 1996, MAGNETIC RESONANCE B NR 4 TC 7 Z9 7 PU HUMANA PRESS INC PI TOTOWA PA 999 RIVERVIEW DRIVE SUITE 208, TOTOWA, NJ 07512 USA SN 1541-6933 J9 NEUROCRIT CARE JI Neurocrit. Care PY 2008 VL 8 IS 2 BP 290 EP 292 DI 10.1007/s12028-007-9032-0 PG 3 WC Critical Care Medicine; Clinical Neurology SC General & Internal Medicine; Neurosciences & Neurology GA 270KE UT WOS:000253718900013 PM 18080099 ER PT J AU Rzeski, M Stepien, A Kaczorowski, Z AF Rzeski, Maciej Stepien, Adam Kaczorowski, Zbigniew TI Evaluation of the function of the vestibular system in patients with migraine SO NEUROLOGIA I NEUROCHIRURGIA POLSKA LA English DT Article DE migraine; vertigo/dizziness; ENG/VNG ID BASILAR ARTERY MIGRAINE; VERTIGO; DIZZINESS; HEADACHE; DISEASE AB Background and purpose: Migraine is a common disorder with 1-year prevalence of 17.2% in women and 6% in men. Otoneurological symptoms such as phonophobia, tinnitus, vertigo, and dizziness are quite common in migraine. It is estimated that vertigo and dizziness are associated with migraine in 10% of all dizzy patients. The aim of the study was to evaluate the function of the vestibular system using electronystagmography (ENG) and videonystagmography (VNG) in patients with migraine compared to healthy controls. Material and methods: Sixty-two patients (46 women and 16 men) aged 20-35 years (mean age: 28.4 years) with migraine were qualified to the study. All other illnesses that can cause dysfunction of the vestibular system were excluded. The control group consisted of 31 healthy Volunteers fulfilling the same demographic criteria as the migraine group (mean age: 29.2 years). Results: Vertigo or dizziness was reported by 41 patients with migraine (66.1%). In ENG/VNG examination changes suggesting impairment of the peripheral or central part of the vestibular system were found in 34 patients (54.8%). In the control group, any abnormalities in ENG/VNG examination were present in 22.6% of individuals (p=0.0031). No statistical significance was found in the frequency of any ENG/VNG abnormalities In Subgroups of patients with migraine with aura and migraine without aura. Factors predisposing to dysfunction of the vestibular system in our group of migraineurs were the frequency and duration of the migraine. Conclusions: Vertigo and dizziness are frequent co-existing symptoms in patients with migraine. ENG/VNG abnormalities are significantly more frequent in migraineurs than in healthy controls. C1 [Rzeski, Maciej] Inst Fizjol & Patol Sluchu, PL-01943 Warsaw, Poland. [Stepien, Adam] Wojskowy Inst Med, Neurol Klin, Warsaw, Poland. [Kaczorowski, Zbigniew] Wojskowy Inst Med Lotniczej, Pracownia Diagnost Narzadu Sluchu & Ukladu Rownow, Warsaw, Poland. RP Rzeski, M (reprint author), Inst Fizjol & Patol Sluchu, Ul Zgrupowania AK Kampinos 1, PL-01943 Warsaw, Poland. EM mrzeski@wp.pl CR Baloh RW, 1997, HEADACHE, V37, P615, DOI 10.1046/j.1526-4610.1997.3710615.x Bayazit Y, 2001, Rev Laryngol Otol Rhinol (Bord), V122, P85 BRANDT T, 2003, VERTIGO ITS MULTISEN, P325 Cass SP, 1997, ANN OTO RHINOL LARYN, V106, P182 Celebisoy N, 2008, CEPHALALGIA, V28, P72, DOI 10.1111/j.1468-2982.2007.01474.x Crevits L, 2005, CLIN NEUROL NEUROSUR, V107, P82, DOI 10.1016/j.clineuro.2004.07.003 CUTRER FM, 1992, HEADACHE, V32, P300, DOI 10.1111/j.1526-4610.1992.hed3206300.x Dieterich M, 1999, J NEUROL, V246, P883, DOI 10.1007/s004150050478 DOMZAL TM, 1996, BOLE GLOWY EVIATAR L, 1981, ANN NEUROL, V9, P126, DOI 10.1002/ana.410090205 Furman JM, 2003, CURR OPIN NEUROL, V16, P5, DOI 10.1097/01.wco.0000053582.70044.e2 Headache Classification Subcommittee of the International Headache Society, 2004, CEPHALALGIA S1, V24, P9, DOI DOI 10.1111/J.1468-2982.2003.00824.X Ishizaki K, 2002, PSYCHIAT CLIN NEUROS, V56, P85, DOI 10.1046/j.1440-1819.2002.00933.x Johnson GD, 1998, LARYNGOSCOPE, V108, P1, DOI 10.1097/00005537-199801001-00001 KACZOROWSKI Z, 2000, SPRAWOZDANIE PRACY S KACZOROWSKI Z, 2002, POLSKI PRZEGL MED LO, V8, P369 KAYAN A, 1984, BRAIN, V107, P1123, DOI 10.1093/brain/107.4.1123 KURITZKY A, 1981, HEADACHE, V21, P110, DOI 10.1111/j.1526-4610.1981.hed2103110.x LaSpina I, 1997, HEADACHE, V37, P43 Leao AAP, 1944, J NEUROPHYSIOL, V7, P359 Lee H, 2000, ARCH NEUROL-CHICAGO, V57, P1631, DOI 10.1001/archneur.57.11.1631 Lee H, 2008, HEADACHE, V48, P1460, DOI 10.1111/j.1526-4610.2007.01002.x Lempert T, 2005, NEUROL CLIN, V23, P715, DOI 10.1016/j.ncl.2005.01.003 Lipton RB, 2007, NEUROLOGY, V68, P343, DOI 10.1212/01.wnl.0000252808.97649.21 LIVEING E, 1873, MEGRIM SICK HEADACHE, P120 Neuhauser H, 2004, CEPHALALGIA, V24, P83, DOI 10.1111/j.1468-2982.2004.00662.x Oh AK, 2001, AM J MED GENET, V100, P287, DOI 10.1002/ajmg.1294 OLSSON JE, 1991, LARYNGOSCOPE, V101, P1 PRUSINSKI A, 2002, ZAWROTY GLOWY, P162 PRUSINSKI A, MIGRENA JEJ WSPOLCZE Radtke A, 2002, NEUROLOGY, V59, P1700 SCHLAKE HP, 1989, CEPHALALGIA, V9, P271, DOI 10.1046/j.1468-2982.1989.0904271.x Split W, 1988, Neurol Neurochir Pol, V22, P383 Thakar A, 2001, J LARYNGOL OTOL, V115, P782 Troost B Todd, 2004, Curr Pain Headache Rep, V8, P310, DOI 10.1007/s11916-004-0014-z NR 35 TC 2 Z9 2 PU TERMEDIA PUBLISHING HOUSE LTD PI POZNAN PA WENEDOW ST 9-1, POZNAN, 61-614, POLAND SN 0028-3843 J9 NEUROL NEUROCHIR POL JI Neurol. Neurochir. Pol. PY 2008 VL 42 IS 6 BP 518 EP 524 PG 7 WC Clinical Neurology SC Neurosciences & Neurology GA 422ZX UT WOS:000264467300005 PM 19235105 ER PT J AU Rawool, VW Colligon-Wayne, LA AF Rawool, Vishakha W. Colligon-Wayne, Lynda A. TI Auditory lifestyles and beliefs related to hearing loss among college students in the USA SO NOISE & HEALTH LA English DT Article DE Hearing loss; hearing protection device; music; noise; tinnitus AB The purpose of this study was to evaluate the auditory life styles and beliefs of college students with reference to exposure to loud sounds in the context of the health belief model. A survey was administered to 238 (40 men, 198 women) students in the USA. Results suggest that 44 of the students use noisy equipment without ear protection and 29 (69/238) of the students work in noisy environments. Of the 69 who worked in noisy surroundings, only ten reported wearing hearing protection devices although 50 (72.46) reported tinnitus. The use of hearing protection devices (HPDs) was associated with previous experience with hearing loss and tinnitus. Although 75 of the students were aware that exposure to loud sounds could cause hearing loss, 50 of the students appeared to be exposing themselves to potentially harmful loud music. Furthermore, 46 of the students reported not using HPDs during loud musical activities because they felt that the music was difficult to hear with HPDs. Most students in this study considered hearing loss to be serious but 76 of the students believed that they would not lose their hearing until a greater age. Although 66 of the students had experienced tinnitus, 58 of these students reported not being concerned about it. These results suggest a critical need for promoting healthy hearing behavior among college students. Possible strategies could include improved education, experience with simulated hearing loss for extended periods and availability of cosmetically appealing or invisible HPDs with uniform attenuation across the frequency range. C1 [Rawool, Vishakha W.] W Virginia Univ, Dept Speech Pathol & Audiol, Morgantown, WV 26505 USA. [Colligon-Wayne, Lynda A.] Princeton Otolaryngol Assoc, Princeton, NJ 08540 USA. RP Rawool, VW (reprint author), W Virginia Univ, Dept Speech Pathol & Audiol, POB 6122, Morgantown, WV 26505 USA. 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Method: There are 42 patients who were randomized into 2 groups according to their order of admission. Group A consists of 31 patients who were subjected to transcutaneous electrical stimulation 3 times a week for 1 month. Group B includes 11 patients who had electrical stimulus attachment but where no stimulus was given (placebo group). The stimulator is a custom-made device which generates direct and alternative current in 10-200 Hz frequency. An alternative low-frequency (not > 100 Hz) pulsed current was used for tinnitus therapy through a preauricular skin electrode. The amplitude of stimulus ranged between 50 and 2,000 mA. The pulse frequency was 30 Hz. Each session lasted for 25 min for both groups. Statistical analysis was performed. Result: The rate of improvement following the therapy was 42.8% (18/42) in the electrical therapy group and 28.5% (4/14) in the placebo group. Conclusion: Electrical suppression of the tinnitus does not offer a promising outcome for patients with tinnitus in the presented study. Copyright (c) 2008 S. Karger AG, Basel. C1 [Kapkin, Osman; Satar, Bulent; Yetiser, Sertac] Gulhane Mil Med Acad, Dept ORL & HNS, TR-06018 Ankara, Turkey. RP Yetiser, S (reprint author), Gulhane Mil Med Acad, Dept ORL & HNS, TR-06018 Ankara, Turkey. EM syetiser@yahoo.com CR ARAN JM, 1983, ANN OTO RHINOL LARYN, V92, P614 ARAN JM, 1981, J LARYNGOL OTOL S, V4, P153 AXELSSON A, 1989, British Journal of Audiology, V23, P53, DOI 10.3109/03005368909077819 Brackmann DE, 1981, J LARYNGOL OTOL S, P163 CAZALS Y, 1984, ARCH OTO-RHINO-LARYN, V239, P191, DOI 10.1007/BF00464243 CAZALS Y, 1978, J AM AUDITORY SOC, V3, P209 CHOUARD CH, 1981, ACTA OTO-LARYNGOL, V91, P415, DOI 10.3109/00016488109138522 Graham J M, 1977, Br J Audiol, V11, P59, DOI 10.3109/03005367709078834 Hazell J. W., 1981, J LAR OTOL S, V4, P39 Hazell J W, 1989, J Laryngol Otol Suppl, V18, P39 HAZELL JWP, 1993, AUDIOLOGY, V32, P68 ITO J, 1994, LARYNGOSCOPE, V104, P752 Konopka W, 2001, AURIS NASUS LARYNX, V28, P35, DOI 10.1016/S0385-8146(00)00086-9 KUK FK, 1989, J SPEECH HEAR RES, V32, P393 Matsushima Jun Ichi, 1994, Auris Nasus Larynx, V21, P17 MCKERROW WS, 1991, ANN OTO RHINOL LARYN, V100, P552 MOLLER AR, 1984, ANN OTO RHINOL LARYN, V93, P39 OKUSA M, 1993, ACTA OTO-LARYNGOL, P54 PORTMANN M, 1979, ACTA OTO-LARYNGOL, V87, P294, DOI 10.3109/00016487909126423 Ruckenstein MJ, 2001, OTOL NEUROTOL, V22, P200, DOI 10.1097/00129492-200103000-00014 Savastano M, 2004, ADV THER, V21, P13, DOI 10.1007/BF02850261 Schulman A., 1985, AM J OTOL, V6, P110 SOULIERE CR, 1992, ARCH OTOLARYNGOL, V118, P1291 Steenerson RL, 1999, OTOLARYNG HEAD NECK, V121, P511, DOI 10.1016/S0194-5998(99)70048-3 THEDINGER B, 1985, ANN OTO RHINOL LARYN, V94, P10 THEDINGER BS, 1987, AUDIOMAX THERABAND L, V97, P33 Vernon J, 1988, TINNITUS PATHOPHYSIO, P36 VERNON JA, 1985, OTOLARYNG HEAD NECK, V93, P385 Watanabe K, 1997, AUDIOLOGY, V36, P147 NR 29 TC 8 Z9 10 PU KARGER PI BASEL PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND SN 0301-1569 J9 ORL J OTO-RHINO-LARY JI ORL-J. Oto-Rhino-Laryngol. Relat. Spec. PY 2008 VL 70 IS 3 BP 156 EP 161 DI 10.1159/000124288 PG 6 WC Otorhinolaryngology SC Otorhinolaryngology GA 297HM UT WOS:000255607700004 PM 18401195 ER PT J AU Bayazit, YA Goksu, N AF Bayazit, Yildirim A. Goksu, Nebil TI Tinnitus and neurovascular compression SO ORL-JOURNAL FOR OTO-RHINO-LARYNGOLOGY AND ITS RELATED SPECIALTIES LA English DT Letter C1 [Bayazit, Yildirim A.; Goksu, Nebil] Gazi Univ, Fac Med, Dept Otolaryngol, TR-06500 Ankara, Turkey. RP Bayazit, YA (reprint author), Gazi Univ, Fac Med, Dept Otolaryngol, TR-06500 Ankara, Turkey. EM bayazity@yahoo.com CR Levine RA, 2006, ORL J OTO-RHINO-LARY, V68, P43, DOI 10.1159/000090490 NR 1 TC 1 Z9 3 PU KARGER PI BASEL PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND SN 0301-1569 J9 ORL J OTO-RHINO-LARY JI ORL-J. Oto-Rhino-Laryngol. Relat. Spec. PY 2008 VL 70 IS 3 BP 209 EP 209 DI 10.1159/000124296 PG 1 WC Otorhinolaryngology SC Otorhinolaryngology GA 297HM UT WOS:000255607700012 PM 18401197 ER PT J AU Alessandra, K Knobel, B Sanchez, TG AF Alessandra, Keila Knobel, Baraldi Sanchez, Tanit Ganz TI Influence of silence and attention on tinnitus perception SO OTOLARYNGOLOGY-HEAD AND NECK SURGERY LA English DT Article; Proceedings Paper CT 19th Annual Conference of the American-Academy-of-Audiology CY APR 18-21, 2007 CL Denver, CO SP Amer Acad Audiol AB OBJECTIVE: The purpose of this study was to study the effect of attention and sustained silence on the emergence of auditory phantom perception in normal-hearing adults. STUDY DESIGN: Cross-sectional survey. SUBJECTS AND METHODS: While sitting in a sound booth, 66 volunteers (age range. 18-65; mean age, 37.3) performed 3 experiments of 5 minutes each, consecutively and randomly presented. Two deviated attention from auditory system (Hanoi and visual attention experiments). and 1 drove attention to the auditory system (auditory attention). After each experiment, participants were asked about their auditory and visual perception. No sound or light change was given at any moment. RESULTS: Of the participants, 19.7% experienced tinnitus during Hanoi, 45.5% during visual attention, and 68.2% during auditory attention experiment. with no significant differences for studied variables. CONCLUSION: Tinnitus-like perceptions may occur in a non-clinical population in a silent environment. Concomitant auditory attention plays an important role on the emergence of tinnitus. (C) 2008 American Academy of Otolaryngology-Head and Neck Surgery Foundation. All rights reserved. C1 [Alessandra, Keila; Knobel, Baraldi; Sanchez, Tanit Ganz] Univ Sao Paulo, Sch Med, ENT Dept, BR-05508 Sao Paulo, Brazil. RP Alessandra, K (reprint author), R Joaquim Novaes, 60 Apt 132, BR-13015918 Campinas, SP, Brazil. EM keila@gabengenharia.com.br CR Andersson G, 2002, CLIN PSYCHOL REV, V22, P977, DOI 10.1016/S0272-7358(01)00124-6 ANZAI Y, 1979, PSYCHOL REV, V86, P124, DOI 10.1037//0033-295X.86.2.124 Chawla D, 1999, NAT NEUROSCI, V2, P671, DOI 10.1038/10230 Eggermont JJ, 2003, AURIS NASUS LARYNX S, V30, P7, DOI 10.1016/S0385-8146(02)00122-0 GAZZALEY A, 1925, J COGNITIVE NEUROSCI, V17, P505 Gilbert CD, 2007, NEURON, V54, P677, DOI 10.1016/j.neuron.2007.05.019 HELLER MF, 1953, ANN OTO RHINOL LARYN, V62, P73 KALTENBACH JA, 2004, EPIDEMIOLOGY, P141 KNOBEL KAB, 2005, ARQ OTORRINOLARINGOL, V9, P306 Lockwood AH, 2002, NEW ENGL J MED, V347, P904, DOI 10.1056/NEJMra013395 Lockwood AH, 1998, NEUROLOGY, V50, P114 Mirz F, 1999, HEARING RES, V134, P133, DOI 10.1016/S0378-5955(99)00075-1 Nuttall AL, 2004, TINNITUS THEORY MANA, P52 Tucker DA, 2005, OTOLARYNG HEAD NECK, V132, P20, DOI 10.1016/j.otohns.2005.08.016 NR 14 TC 0 Z9 0 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0194-5998 J9 OTOLARYNG HEAD NECK JI Otolaryngol. Head Neck Surg. PD JAN PY 2008 VL 138 IS 1 BP 18 EP 22 DI 10.1016/j.otohns.2007.09.023 PG 5 WC Otorhinolaryngology; Surgery SC Otorhinolaryngology; Surgery GA 250ES UT WOS:000252283400004 ER PT J AU Tringali, S Dubreuil, C Zaouche, S Ferber-Viart, C AF Tringali, Stephane Dubreuil, Christian Zaouche, Sandra Ferber-Viart, Chantal TI Are Stage IV vestibular schwannomas preoperatively different from other stages? SO OTOLOGY & NEUROTOLOGY LA English DT Article DE auditory brainstem response; large vestibular schwannomas; preoperative factors; videonystamography ID ACOUSTIC NEUROMAS; PRESERVATION; SURGERY AB Objective: The aim of this study was to focus on the clinical and paraclinical symptoms of patients suffering from Stage IV vestibular schwannomas (VSs). Patients: In this prospective study, we included 734 patients who have VS and candidates for operation. Main Outcome Measures: Patients were classified as having Stage I, II, III, or IV tumors according to Tos criteria as evaluated by magnetic resonance imaging. Preoperative Clinical Evaluation: We recorded the occurrence of complaints (%) and duration (yr) of hearing loss, tinnitus, and balance disorder. Preoperative paraclinical evaluation included pure-tone (PTA) and speech audiometry, auditory brainstem response (ABR) patterns, and vestibular deficit at videonystamography (VNG). Continuous variables were compared between Stage IV and other stages using analysis of variance. Qualitative variables expressed as a percentage of presence were compared between Stage IV and other stages using percentage comparison. Results: Quantitative Parameters. Patients with Stage IV VS were significantly younger as compared with patients with other stages. Stage IV hearing loss was greater compared with other stages at 250 and 500 Hz but smaller at 2,000 and 8,000 Hz. We found no difference in the loss of PTA between Stage IV and the other stages. Speech discriminancy score was smaller in Stage IV. The durations of hearing loss, tinnitus, and balance disorders were similar whatever the tumor stage. Auditory brainstem response patterns showed no difference in Wave III latency between Stage IV VS and other stages, whereas Wave V latency and V-I interval were higher in Stage IV. Both ABR threshold and VNG caloric deficit were higher in Stage IV VS compared with other stages. Qualitative Parameters. The percentage of patients with Stage IV was lower than that with Stages II and III. The percentage of men and women was similar in all stages. The occurrence of hearing loss was similar in all stages, whereas that of tinnitus was lower in Stage IV compared with Stages I and II. In contrast, the occurrence of balance disorder was higher in Stage IV compared with all other stages. Conclusion: In clinical and paraclinical manifestation, Stage IV VS is different from the other stages. The PTA differences may be attributed to the younger age. Occurrence of clinical symptoms, ABR, and VNG pattern can be explained by the fact that Stage IV develops rapidly in the vestibular, rather than the cochlear nerve and by the fact that larger tumors can be cerebellar compression. This has been confirmed by the higher occurrence of balance disorders in Stage IV and the lower occurrence of tinnitus with similar hearing loss in all stages. C1 [Tringali, Stephane; Dubreuil, Christian; Zaouche, Sandra] Hosp Civils Lyon, Ctr Hosp Lyon Sud, Serv Otoneurochirurg, F-69495 Pierre Benite, France. [Ferber-Viart, Chantal] Ctr Hosp Lyon Sud, F-69310 Pierre Benite, France. [Ferber-Viart, Chantal] UCB Lyon 1, Inst Fed Neurosci, UMR Neurosci & Syst Sensoriels, Lyon, France. RP Tringali, S (reprint author), Hosp Civils Lyon, Ctr Hosp Lyon Sud, Serv Otoneurochirurg, F-69495 Pierre Benite, France. EM stephane.tringali@chu-lyon.fr CR Anderson DE, 2005, J NEUROSURG, V102, P643, DOI 10.3171/jns.2005.102.4.0643 Charabi S, 1996, ACTA OTO-LARYNGOL, V116, P59, DOI 10.3109/00016489609137713 Ferber-Viart C, 2000, LARYNGOSCOPE, V110, P145, DOI 10.1097/00005537-200001000-00026 Lanman TH, 1999, J NEUROSURG, V90, P617, DOI 10.3171/jns.1999.90.4.0617 Matthies C, 1997, NEUROSURGERY, V40, P1 Nicoucar K, 2006, J NEUROSURG, V105, P205, DOI 10.3171/jns.2006.105.2.205 Rosenberg SI, 2000, LARYNGOSCOPE, V110, P497, DOI 10.1097/00005537-200004000-00002 TOS M, 1992, ACOUSTIC NEUROMA, P975 Yamakami I, 2004, J NEUROL NEUROSUR PS, V75, P453, DOI 10.1136/jnnp.2003.010827 NR 9 TC 5 Z9 5 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1531-7129 J9 OTOL NEUROTOL JI Otol. Neurotol. PD JAN PY 2008 VL 29 IS 1 BP 46 EP 49 PG 4 WC Clinical Neurology; Otorhinolaryngology SC Neurosciences & Neurology; Otorhinolaryngology GA 249IT UT WOS:000252222200010 PM 18046259 ER PT J AU Tawil, A Comair, Y Nasser, H Hourani, R Rebeiz, J Chamoun, R AF Tawil, Ayman Comair, Youssef Nasser, Haitham Hourani, Roula Rebeiz, Jean Chamoun, Roukoz TI Periosteal osteoblastoma of the calvaria mimicking a meningioma SO PATHOLOGY RESEARCH AND PRACTICE LA English DT Article DE osteoblastoma; calvarial; metaplastic meningioma; epithelial membrane antigen ID BENIGN OSTEOBLASTOMA; TEMPORAL BONE; PARIETAL BONE; AGGRESSIVE OSTEOBLASTOMA; SKULL; LESION; MRI AB While osteoblastoma of the cranial vault is rare, the periosteal form of the tumor is highly unusual, with only one case reported in the English literature. We report on a 24-year-old woman presenting with headache and tinnitus. Magnetic resonance imaging of the brain showed an extra-axial temporal mass with findings that were suggestive of a meningioma. The mass was excised completely, and histological examination revealed a periosteal osteoblastoma arising from the inner surface of the temporal bone and adhering to the dura. The tumor was strongly positive for epithelial membrane antigen, a feature not previously described in osteoblastoma, and one that could lead to a mistaken diagnosis of metaplastic meningioma in a limited sample. A detailed literature review of 40 other reported cases of calvarial osteoblastoma is presented. Apart from being slightly more common in females, calvarial osteoblastoma is similar in all other respects to that arising at conventional skeletal sites. Accurate histological diagnosis of a calvarial osteoblastoma requires adequate sampling of the tumor, including its interface with adjacent structures. Correlation with the radiological findings is crucial for the diagnosis in most cases; however, it is not helpful in differentiating the rare intracranial periosteal variant from a meningioma. (C) 2008 Elsevier GmbH. All rights reserved. C1 [Tawil, Ayman; Nasser, Haitham; Rebeiz, Jean] Amer Univ Beirut, Med Ctr, Dept Pathol & Lab Med, Beirut 11072020, Lebanon. [Comair, Youssef; Chamoun, Roukoz] Amer Univ Beirut, Med Ctr, Div Neurosurg, Dept Surg, Beirut 11072020, Lebanon. [Hourani, Roula] Amer Univ Beirut, Med Ctr, Dept Radiol, Beirut 11072020, Lebanon. RP Tawil, A (reprint author), Amer Univ Beirut, Med Ctr, Dept Pathol & Lab Med, POB 11-023, Beirut 11072020, Lebanon. 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If that is not executed in the normal way severe developmental disorders such as autism may results. Normal development of functions and anatomical organization of the brain and the spinal cord depend on appropriate sensory stimulation and motor activations. So-called enriched sensory environments have been shown to be beneficial for cognitive development and enriched acoustic environment may even slow the progression of age-related hearing loss. It is possible that the beneficial effect of physical exercise is achieved through activation of neural plasticity. The beneficial effect of training after trauma to the brain or spinal cord is mainly achieved through shifting functions from damaged brain area to other parts of the central nervous system and adapting these parts to take over the functions that are lost. This is accomplished through activation of neural plasticity. 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Evaluations were carried out on 779 medical records from HIV- infected patients who were being regularly followed up, of whom 162 were being treated with antiretroviral therapy and 122 were untreated ( controls). The patients undergoing treatment were older ( mean: 42 years), had had serological confirmation for longer times ( 80 months) and had smaller viral loads ( P = 0.00). CD4+ was similar between the groups ( P = 0.60). In the treated group, three cases ( 1.8%) of idiopathic hearing loss and two ( 1.3%) of otosclerosis- related hearing loss were observed, which both started after antiretroviral therapy. No statistical difference relating to idiopathic hearing loss was found between the groups. While descriptive studies consider possible ototoxicity associated with antiretroviral therapy, this possible adverse effect was not related to the antiretroviral therapy in this study. Conversely, otosclerosis might have been correlated with antiretroviral therapy. This issue deserves to be studied. C1 [Maciel Teofilo, Marcia Miliane; Goncalves, Denise Utsch] Univ Fed Minas Gerais, FM, Dept Oftalmol Otorrinolaringol & Fonoaudiol, BR-30130100 Belo Horizonte, MG, Brazil. [Cheloni Vieira, Andreza Batista; Goncalves, Denise Utsch] Univ Fed Minas Gerais, Fac Med, Programa Posgrad Ciencias Saude, Belo Horizonte, MG, Brazil. [Greco, Dirceu Bartolomeu] Univ Fed Minas Gerais, Fac Med, Dept Clin Med, Belo Horizonte, MG, Brazil. RP Goncalves, DU (reprint author), Univ Fed Minas Gerais, FM, Dept Oftalmol Otorrinolaringol & Fonoaudiol, Av Alfredo Balena 190 Sala 3005, BR-30130100 Belo Horizonte, MG, Brazil. 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Soc. Bras. Med. Trop. PD JAN-FEB PY 2008 VL 41 IS 1 BP 65 EP 69 PG 5 WC Tropical Medicine SC Tropical Medicine GA 279XC UT WOS:000254387500012 PM 18368273 ER PT J AU Gerhards, F AF Gerhards, Friedemann TI Effects of distraction and relaxation training in chronic tinnitus and impact of individual case complexity SO VERHALTENSTHERAPIE LA German DT Article DE tinnitus; case complexity; treatment success; psychological intervention; treatment setting; differential indication ID GROUP-THERAPY; PSYCHOLOGICAL TREATMENTS; MANAGEMENT; OUTPATIENTS AB Background: In the case of complex chronic tinnitus many experts recommend inpatient rather than outpatient psychological treatment. Severe tinnitus-related distress and psychopathology are supposed to make treatment success difficult and are to be compensated by increased treatment efforts. Yet, evidence for the impact of case complexity on treatment effects is weak or equivocal. Patients and Methods: In a prospective randomized controlled trial with 139 tinnitus patients we investigated if previous findings on the effectiveness of an outpatient computer-aided and machine-assisted distraction and relaxation training (DRT) can be corroborated and to what extent case complexity is relevant for the short-to long-term success of the training. Treatment success was assessed by use of reliable and valid instruments for tinnitus-related distress, tinnitus coping and emotional distress not related to tinnitus. Furthermore, we analyzed whether outpatient DRT is also effective in patients with similarly complex tinnitus as in most of the inpatient population. The effect of DRT in these outpatients was contrasted with that of inpatient treatment. Results: DRT yielded a long-lasting reduction of tinnitus-related distress and increased utilization of self-encouragement, relaxation, and attention diversion to cope with tinnitus. Intervention-specific changes in emotional distress not related to tinnitus were non-certifiable. There was no evidence that increased case complexity curtailed treatment success. The contrast of the effects of inpatient treatment and DRT indicated no advantage of the former. Conclusions: Recommending different therapeutic approaches according to tinnitus complexity seems rather eminence- than evidence-based. Further research on differential treatment indication and on dose-response relationship is required. C1 Univ Trier, Forschungszentrum Psychobiol & Psychomat, D-54290 Trier, Germany. RP Gerhards, F (reprint author), Univ Trier, Forschungszentrum Psychobiol & Psychomat, Johanniterufer 15, D-54290 Trier, Germany. 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Method: 121 patients suffering from tinnitus were examined by unique testing in a tinnitus-practice via three questionnaires over a period of 22 months. Results: A relationship between the severity of tinnitus-related distress and demographic profile as well as a relationship between depression symptoms and the severity of the tinnitus-related distress could be shown. Also, significant results were observed within the personality range in the areas of "impulsiveness," "aggressiveness," "demands," "physical discomfort," "health worries," und "emotionality." Discussion: Patients suffering severely from tinnitus represent a clinically relevant group for psychotherapeutic treatment. Especially persons with comorbid symptoms of depression should be screened regularly and offered additional psychotherapeutic or psychiatric treatment. C1 [Weber, Judith Hanna] Evangel Krankenhaus, A-1180 Vienna, Austria. [Jagsch, Reinhold] Univ Vienna, Inst Klin Biol & Differentielle Psychol, A-1010 Vienna, Austria. [Hallas, Barbara] Klin Psychol & Psychotherapeut Praxis, Vienna, Austria. RP Weber, JH (reprint author), Evangel Krankenhaus, Hans Sachs Gasse 10-12, A-1180 Vienna, Austria. EM jhweber@chello.at CR Andersson G, 2002, CLIN PSYCHOL REV, V22, P977, DOI 10.1016/S0272-7358(01)00124-6 Andersson G, 2003, J PSYCHOSOM RES, V55, P259, DOI 10.1016/S0022-3999(02)00575-5 Baldo P, 2006, COCHRANE DB SYST REV, V4 BIESINGER E, 2002, BEHANDLUNG OHRGERAUS Budd RJ, 1995, J PSYCHOSOM RES, V39, P1015, DOI 10.1016/0022-3999(95)00512-9 DELB W, 2002, TINNITUS MANUAL TINN DEVESA DPM, 2007, COCHRANE DB SYST REV, V1, DOI UNSP CD005233 Einsle F, 2006, Z PSYCHOSOM MED PSYC, V52, P373 FAHRENBERG J, 1994, FPI R FREIBURGER PER Folmer RL, 1999, OTOLARYNG HEAD NECK, V121, P48, DOI 10.1016/S0194-5998(99)70123-3 Goebel G, 2003, TINNITUS HYPERAKUSIS GOEBEL G, 1998, TF TINNITUSFRAGEBOGE HALFORD JBS, 1991, J PSYCHOSOM RES, V35, P383, DOI 10.1016/0022-3999(91)90033-K HARROPGRIFFITHS J, 1987, J PSYCHOSOM RES, V31, P613, DOI 10.1016/0022-3999(87)90040-7 Hautzinger M., 1994, BECK DEPRESSIONS INV HAWTHORNE M, 1987, BRIT MED J, V294, P1441 Holgers KM, 2000, AUDIOLOGY, V39, P284 Jager B, 2001, Z KL PSYCH PSYCHOTH, V30, P1, DOI 10.1026//1616-3443.30.1.1 KONZAG TA, 2003, Z PSYCHOSOM MED PSYC, V51, P247 Langenbach M, 2005, GEN HOSP PSYCHIAT, V27, P73, DOI 10.1016/j.genhosppsych.2004.08.008 Marciano E, 2003, INT J AUDIOL, V42, P4, DOI 10.3109/14992020309056079 MCKENNA L, 1991, CLIN OTOLARYNGOL, V16, P452, DOI 10.1111/j.1365-2273.1991.tb01038.x SCHILTER B, 2000, THERAPIE CHRONISCHEN SCHNEIDER WR, 1994, HNO, V4, P22 Scott B, 2000, PSYCHOSOMATICS, V41, P347, DOI 10.1176/appi.psy.41.4.347 SCOTT B, 2001, OHRGERAUSCHE PSYCHOS, P33 Tagay Sefik, 2007, Z Psychosom Med Psychother, V53, P62 Wise K, 1998, J PSYCHOSOM RES, V44, P681, DOI 10.1016/S0022-3999(97)00310-3 WOOD KA, 1983, PSYCHOSOMATICS, V24, P559 Zoger S, 2006, PSYCHOSOMATICS, V47, P282, DOI 10.1176/appi.psy.47.4.282 Zoger S, 2003, J PSYCHOSOM RES, V55, P142, DOI 10.1016/S0022-3999(03)00358-1 Zoger S, 2003, J PSYCHOSOM RES, V55, P134, DOI 10.1016/S0022-3999(03)00316-7 NR 32 TC 13 Z9 13 PU VANDENHOECK & RUPRECHT PI GOTTINGEN PA THEATERSTRASSE 13,, D-37073 GOTTINGEN, GERMANY SN 1438-3608 J9 Z PSYCHOSOM MED PSYC JI Z. Psychosom. Med. Psychother. PY 2008 VL 54 IS 3 BP 227 EP 240 PG 14 WC Psychology, Clinical; Psychiatry; Psychology; Psychology, Multidisciplinary; Psychology, Psychoanalysis SC Psychology; Psychiatry GA 353IE UT WOS:000259558900003 PM 18713536 ER PT J AU Kunelskaya, NL Umarova, KY Gulieva, AE Chugunov, AV Kamchatnov, PR AF Kunelskaya, N. L. Umarova, Kh. Ya. Gulieva, A. E. Chugunov, A. V. Kamchatnov, P. R. TI Correction of affective disorders in patients with cochlear-vestibular disturbances of vascular origin SO ZHURNAL NEVROLOGII I PSIKHIATRII IMENI S S KORSAKOVA LA Russian DT Article ID TINNITUS; INFARCTION; ISCHEMIA; TRIALS; STROKE; RISK C1 [Kunelskaya, N. L.; Umarova, Kh. Ya.; Gulieva, A. E.; Chugunov, A. V.; Kamchatnov, P. R.] Russian State Med Univ, Moscow Sci Ctr Otorhinolaryngol, Moscow 117437, Russia. RP Kunelskaya, NL (reprint author), Russian State Med Univ, Moscow Sci Ctr Otorhinolaryngol, Moscow 117437, Russia. CR ALEKSEYEVA NS, 2004, ZH NEVROPATOL PSIKH, V10, P16 Blacker DJ, 2003, STROKE, V34, P2659, DOI 10.1161/01.STR.0000092120.03676.D6 Caplan L, 2000, STROKE, V31, P2011 Baigent C, 2002, BRIT MED J, V324, P71 DOBIE RA, 1993, AM J OTOL, V14, P18 Dobie RA, 1999, LARYNGOSCOPE, V109, P1202, DOI 10.1097/00005537-199908000-00004 GUSEV YEI, 2001, ISHEMIYA GOLOVNOGO M GUSEV YI, 2001, OSNOVNYE NEVROLOGICH JOHNSON RM, 1993, ARCH OTOLARYNGOL, V119, P842 LECHTENBERG R, 1984, J LARYNGOL OTOL S9, V98, P271 Lee H, 2003, J NEUROL NEUROSUR PS, V74, P1644, DOI 10.1136/jnnp.74.12.1644 Lockwood AH, 2002, NEW ENGL J MED, V347, P904, DOI 10.1056/NEJMra013395 Martin PJ, 1998, QJM-MON J ASSOC PHYS, V91, P799, DOI 10.1093/qjmed/91.12.799 MURAI K, 1992, AM J OTOL, V13, P454 Park JB, 2000, ARCH OTOLARYNGOL, V126, P489 VERESHCHAGIN NV, 1997, PATOLOGIYA GOLOVNOGO Weiser M, 1998, ARCH OTOLARYNGOL, V124, P879 Yamamoto Y, 1999, ARCH NEUROL-CHICAGO, V56, P824, DOI 10.1001/archneur.56.7.824 NR 18 TC 0 Z9 0 PU IZDATELSTVO MEDITSINA PI MOSCOW PA PETROVERIGSKII PER 6-8, K-142 MOSCOW, RUSSIA SN 0044-4588 J9 ZH NEVROL PSIKHIATR JI Z. Nevrol. Psikhiatrii Im S S Korsakova PY 2008 VL 108 IS 4 BP 81 EP 83 PG 3 WC Clinical Neurology; Psychiatry SC Neurosciences & Neurology; Psychiatry GA 313WK UT WOS:000256770500013 PM 18567196 ER PT J AU Oldenburg, J Kraggerud, SM Brydoy, M Cvancarova, M Lothe, RA Fossa, SD AF Oldenburg, Jan Kraggerud, Sigrid M. Brydoy, Marianne Cvancarova, Milada Lothe, Ragnhild A. Fossa, Sophie D. TI Association between long-term neuro-toxicities in testicular cancer survivors and polymorphisms in glutathione-s-transferase-P1 and-M1, a retrospective cross sectional study SO JOURNAL OF TRANSLATIONAL MEDICINE LA English DT Article ID S-TRANSFERASE P1; OXALIPLATIN-BASED CHEMOTHERAPY; COLORECTAL-CANCER; NERVOUS-SYSTEM; HEARING-LOSS; GLUTATHIONE; CISPLATIN; NEUROTOXICITY; SUSCEPTIBILITY; OTOTOXICITY AB Background: To assess the impact of polymorphisms in Glutathione S-transferase (GST) -P1, M1, and -T1 on self-reported chemotherapy-induced long-term toxicities in testicular cancer survivors (TCSs). Methods: A total of 238 TCSs, who had received cisplatin-based chemotherapy at median twelve years earlier, had participated in a long-term follow-up survey which assessed the prevalence of self-reported paresthesias in fingers/toes, Raynaud-like phenomena in fingers/toes, tinnitus, and hearing impairment. From all TCSs lymphocyte-derived DNA was analyzed for the functional A. G polymorphism at bp 304 in GSTP1, and deletions in GST-M1 and GST-T1. Evaluation of associations between GST polymorphisms and self-reported toxicities included adjustment for prior treatment. Results: All six evaluated toxicities were significantly associated with the cumulative dose of cisplatin and/or bleomycin. Compared to TCSs with either GSTP1-AG or GSTP1-AA, the 37 TCSs with the genotype GSTP1-GG, were significantly less bothered by paresthesias in fingers and toes (p = 0.039, OR 0.46 [0.22-0.96] and p = 0.023, OR 0.42 [0.20-0.88], respectively), and tinnitus (p = 0.008, OR 0.33 [0.14-0.74]). Furthermore, absence of functional GSTM1 protected against hearing impairment (p = 0.025, OR 1.81 [1.08-3.03]). Conclusion: In TCSs long-term self-reported chemotherapy-induced toxicities are associated with functional polymorphisms in GSTP1 and GSTM1. Hypothetically, absence of GST-M1 leaves more glutathione as substrate for the co-expressed GST-P1. Also intracellular inactivation of proapoptotic mediators represents a possible explanation of our findings. Genotyping of these GSTs might be a welcomed step towards a more individualized treatment of patients with metastatic testicular cancer. C1 [Oldenburg, Jan; Fossa, Sophie D.] Norwegian Radium Hosp, Dept Clin Canc Res, Oslo, Norway. [Oldenburg, Jan; Fossa, Sophie D.] Univ Oslo, Fac Med, N-0310 Oslo, Norway. [Kraggerud, Sigrid M.; Lothe, Ragnhild A.] Norwegian Radium Hosp, Inst Canc Res, Dept Canc Prevent, Oslo, Norway. [Kraggerud, Sigrid M.; Lothe, Ragnhild A.] Univ Oslo, Ctr Canc Biomed, N-0316 Oslo, Norway. [Brydoy, Marianne] Haukeland Hosp, Dept Oncol & Med Phys, N-5021 Bergen, Norway. [Brydoy, Marianne] Univ Bergen, Inst Med, Sect Oncol, Bergen, Norway. [Cvancarova, Milada] Norwegian Radium Hosp, Biostat Sect, Oslo, Norway. RP Oldenburg, J (reprint author), Norwegian Radium Hosp, Dept Clin Canc Res, Oslo, Norway. EM janolde@ulrik.uio.no; Sigrid.M.Kraggerud@rr-research.no; marianne.brydoy@helse-bergen.no; miladacv@math.uio.no; rlothe@radium.uio.no; s.d.fossa@klinmed.uio.no CR Adler V, 1999, EMBO J, V18, P1321, DOI 10.1093/emboj/18.5.1321 Ahmad N, 2004, DRUG AGING, V21, P297, DOI 10.2165/00002512-200421050-00002 Allan JM, 2001, P NATL ACAD SCI USA, V98, P11592, DOI 10.1073/pnas.191211198 BEISWANGER CM, 1995, NEUROTOXICOLOGY, V16, P425 Bokemeyer C, 1998, BRIT J CANCER, V77, P1355, DOI 10.1038/bjc.1998.226 Bokemeyer C, 1996, J CLIN ONCOL, V14, P2923 Brydoy M, 2005, J NATL CANCER I, V97, P1580, DOI 10.1093/jnci/dji339 Cascinu S, 2002, J CLIN ONCOL, V20, P3478, DOI 10.1200/JCO.2002.07.061 Cho SG, 2001, J BIOL CHEM, V276, P12749, DOI 10.1074/jbc.M005561200 CONSTANCE V, 2003, CANC INVESTIGATION, V21, P439 Einhorn LH, 2002, P NATL ACAD SCI USA, V99, P4592, DOI 10.1073/pnas.072067999 EINHORN LH, 1981, CANCER RES, V41, P3275 Ekborn A, 2000, HEARING RES, V140, P38, DOI 10.1016/S0378-5955(99)00190-2 Fossa SD, 2003, J CLIN ONCOL, V21, P1249, DOI 10.1200/JCO.2003.08.163 Fossa SD, 1996, SUPPORT CARE CANCER, V4, P118, DOI 10.1007/BF01845761 Fossa SD, 2004, ACTA ONCOL, V43, P134, DOI 10.1080/02841860310023174 Harries LW, 1997, CARCINOGENESIS, V18, P641, DOI 10.1093/carcin/18.4.641 Hausheer FH, 2006, SEMIN ONCOL, V33, P15, DOI 10.1053/j.seminoncol.2005.12.010 Hayes JD, 2005, ANNU REV PHARMACOL, V45, P51, DOI 10.1146/annurev.pharmtox.45.120403.095857 Henderson CJ, 2005, METHOD ENZYMOL, V401, P116, DOI 10.1016/S0076-6879(05)01007-4 Hochster HS, 2007, J CLIN ONCOL, V25, P4028, DOI 10.1200/JCO.2007.13.5251 Hohaus S, 2005, CLIN CANCER RES, V11, P2175, DOI 10.1158/1078-0432.CCR-04-1250 Ishimoto TM, 2002, PHARMACOGENETICS, V12, P543, DOI 10.1097/00008571-200210000-00006 Kaltenbach JA, 2002, J NEUROPHYSIOL, V88, P699, DOI 10.1152/jn00893.2001 Kobayashi T, 2004, J UROLOGY, V171, P1929, DOI 10.1097/01.JU.0000122901.70300.20 Kristensen T, 1998, BIOTECHNIQUES, V24, P832 Lecomte T, 2006, CLIN CANCER RES, V12, P3050, DOI 10.1158/1078-0432.CCR-05-2076 Listowsky Irving, 1998, Chemico-Biological Interactions, V111-112, P103, DOI 10.1016/S0009-2797(97)00154-3 McDonald ES, 2005, NEUROBIOL DIS, V18, P305, DOI 10.1016/j.nbd.2004.09.013 MCLLWAIN CC, 2006, ONCOGENE, V25, P1639 Oldenburg J, 2007, J CLIN ONCOL, V25, P708, DOI 10.1200/JCO.2006.08.9599 Oldenburg J, 2006, QUAL LIFE RES, V15, P791, DOI 10.1007/s11136-005-5370-6 Pace A, 2003, J CLIN ONCOL, V21, P927, DOI 10.1200/JCO.2003.05.139 PHILBERT MA, 1995, NEUROTOXICOLOGY, V16, P349 Richiardi L, 2007, INT J CANCER, V120, P623, DOI 10.1002/ijc.22345 SINGHAL SS, 1994, ARCH BIOCHEM BIOPHYS, V311, P242, DOI 10.1006/abbi.1994.1233 Stava C, 2005, ONCOL REP, V13, P1193 Stoehlmacher J, 2002, J NATL CANCER I, V94, P936 Strumberg D, 2002, ANN ONCOL, V13, P229, DOI 10.1093/annonc/mdf058 von Schlippe M, 2001, BRIT J CANCER, V85, P823, DOI 10.1054/bjoc.2001.2006 Wang J, 2004, CANCER RES, V64, P9217, DOI 10.1158/0008-5472.CAN-04-1581 Whitlon DS, 1999, HEARING RES, V137, P43, DOI 10.1016/S0378-5955(99)00136-7 WILLIAMS SD, 1987, NEW ENGL J MED, V316, P1435, DOI 10.1056/NEJM198706043162302 NR 43 TC 29 Z9 31 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1479-5876 J9 J TRANSL MED JI J. Transl. Med. PD DEC 27 PY 2007 VL 5 AR 70 DI 10.1186/1479-5876-5-70 PG 8 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA 266UG UT WOS:000253462000001 PM 18162130 ER PT J AU Horie, Y Kitaichi, N Takemoto, Y Namba, K Yoshida, K Hirose, S Hasumi, Y Ota, M Inoko, H Mizuki, N Ohno, S AF Horie, Yukihiro Kitaichi, Nobuyoshi Takemoto, Yuko Namba, Kenichi Yoshida, Kazuhiko Hirose, Shigeto Hasumi, Yukiko Ota, Masao Inoko, Hidetoshi Mizuki, Nobuhisa Ohno, Shigeaki TI Polymorphism of IFN-gamma gene and Vogt-Koyanagi-Harada disease SO MOLECULAR VISION LA English DT Article ID CA REPEAT POLYMORPHISM; RHEUMATOID-ARTHRITIS; JAPANESE PATIENTS; CYTOKINE PROFILE; 1ST INTRON; INTERFERON; ASSOCIATION; SUSCEPTIBILITY; INFLAMMATION; UVEITIS AB Purpose: Interferon-gamma (IFN-gamma) is a key cytokine in inflammatory disorders. Elevated aqueous and serum levels of IFN-gamma levels have been reported to be elevated in patients with Vogt-Koyanagi-Harada (VKH) disease. The aim of this study was to determine the IFN-gamma gene polymorphisms in VKH disease. Methods: The study involved 136 VKH patients and 176 healthy controls, who were genotyped for functional single nucleotide polymorphism (SNP; rs2430561; A/T) and functional microsatellite (CA) repeats (rs3138557) in the first intron of the IFN-gamma gene. Moreover, clinical manifestations of the patients were also analyzed. Results: Diffuse choroiditis/staining of fluorescein angiography was seen in all VKH patients in this study. Sunset glow fundus and nummular chorioretinal depigmented scars were observed in 83.9%, and 36.1% of the patients, respectively. Neurological and auditory disorders were observed in 90.1% of the patients: meningismus (79.8%), tinnitus (53.0%), and cerebrospinal fluid pleocytosis (70.0%). Dermatologic manifestations were observed in 22.9% of the patients, manifesting as alopecia (6.9%), poliosis (17.6%), and vitiligo (13.0%). In addition, 22.1% of the patients were classified as having complete VKH disease, while 65.4% as having incomplete VKH disease, and 12.5% as having probable VKH disease. There were no significant differences in the allele and genotype frequencies between VKH patients and healthy controls. In addition, we found no association between each clinical manifestation and SNP (re2430561) in the healthy control subject. A strong linkage disequilibrium (LD) was found in the functional SNP T allele and functional microsatellite 12 (CA) repeats (D' = 0.96-0.99). Conclusions: The functional SNP T allele and microsatellite 12 (CA) repeats were found to have a strong LD, although a genetic susceptibility for the IFN-gamma gene could not be demonstrated among the Japanese VKH patients. C1 [Horie, Yukihiro; Kitaichi, Nobuyoshi; Takemoto, Yuko; Namba, Kenichi; Yoshida, Kazuhiko; Ohno, Shigeaki] Hokkaido Univ, Grad Sch Med, Dept Ophthalmol & Visual Sci, Kita Ku, Sapporo, Hokkaido 0608638, Japan. [Hirose, Shigeto] Shinohara Eye Clin, Obihiro, Hokkaido, Japan. [Hasumi, Yukiko; Mizuki, Nobuhisa] Yokohama City Univ, Sch Med, Dept Ophthalmol, Yokohama, Kanagawa 232, Japan. [Ota, Masao] Shinshu Univ, Sch Med, Dept Legal Med, Matsumoto, Nagano 390, Japan. [Inoko, Hidetoshi] Tokai Univ, Sch Med, Dept Basic Med Sci & Mol Med, Isehara, Kanagawa 25911, Japan. RP Horie, Y (reprint author), Hokkaido Univ, Grad Sch Med, Dept Ophthalmol & Visual Sci, Kita Ku, N-15,W-7, Sapporo, Hokkaido 0608638, Japan. 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Vis. PD DEC 21 PY 2007 VL 13 IS 261-65 BP 2334 EP 2338 PG 5 WC Biochemistry & Molecular Biology; Ophthalmology SC Biochemistry & Molecular Biology; Ophthalmology GA 310RM UT WOS:000256547800004 PM 18199975 ER PT J AU Zhang, JS Guan, ZL AF Zhang, Jinsheng Guan, Zhenlong TI Pathways involved in somatosensory electrical modulation of dorsal cochlear nucleus activity SO BRAIN RESEARCH LA English DT Article DE tinnitus; somatosensory electrical; suppression; dorsal cochlear nucleus; spinal trigeminal nucleus; dorsal raphe nucleus; locus coeruleus ID FOS-LIKE IMMUNOREACTIVITY; CUTANEOUS-EVOKED TINNITUS; AUDITORY PATHWAY; PROMONTORY STIMULATION; NEURAL PLASTICITY; LIMBIC SYSTEM; GRANULE CELLS; DEAF PATIENTS; GUINEA-PIG; RAT AB Our recent study has shown that somatosensory electrical stimulation may be useful to modulate sound-induced hyperactivity in the dorsal cochlear nucleus (DCN), a neural correlate of certain forms of tinnitus. Somatosensory electrical stimulation induced both suppressive and excitatory effects on neural activity in the DCN of both control and tone-exposed animals. However, it is unclear what neural pathways underlie the somatosensory electrical stimulation-induced effects on DCN activity. To address this issue, we conducted c-fos immunocytochemistry using hamsters and mapped neural activation in both auditory and non-auditory structures following transcutaneous electrical stimulation of the basal part of the pinna. We also conducted tracing experiments to investigate the anatomical relations between the DCN and structures that showed a significant increase in the number of Fos-positive neurons as a result of electrical stimulation. Electrical stimulation of the pinna. induced significant increases in the number of Fos-positive neurons in the DCN, spinal trigeminal nucleus (Sp5), dorsal raphe nucleus (DR) and locus coeruleus (LC). Results of tracing experiments indicate that the DCN received inputs from the Sp5, DR and LC. The above results suggest that modulation of DCN activity through somatosensory electrical stimulation may involve both direct pathways via the Sp5 and indirect pathways via the DR and LC. Therefore, relieving tinnitus through somatosensory electrical stimulation may require manipulations of both auditory and non-auditory functions. (C) 2007 Elsevier B.V. All rights reserved. C1 [Zhang, Jinsheng; Guan, Zhenlong] Wayne State Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, Lab Auditory Prostheses Res, Detroit, MI 48201 USA. [Zhang, Jinsheng] Wayne State Univ, Coll Liberal Arts & Sci, Dept Commun Sci & Disorders, Detroit, MI 48202 USA. [Guan, Zhenlong] Hebei Normal Univ, Coll Life Sci, Dept Zool, Shijiazhuang 050016, Hebei, Peoples R China. RP Zhang, JS (reprint author), Wayne State Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, Lab Auditory Prostheses Res, 5E-UHC,4201 St Antonie, Detroit, MI 48201 USA. 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PD DEC 12 PY 2007 VL 1184 BP 121 EP 131 DI 10.1016/j.brainres.2007.09.061 PG 11 WC Neurosciences SC Neurosciences & Neurology GA 247RF UT WOS:000252096600014 PM 17964553 ER PT J AU Lucas, CD Zabramski, JM AF de Paula Lucas, C. Zabramski, J. M. TI Dural arteriovenous fistula of the transverse-sigmoid sinus causing trigeminal neuralgia SO ACTA NEUROCHIRURGICA LA English DT Article DE dural arteriovenous fistula; transverse-sigmoid sinus; trigeminal neuralgia ID VENOUS DRAINAGE; MALFORMATIONS; EMBOLIZATION; INTERRUPTION AB The authors analysed an unusual case of dural arteriovenous fistula (DAVF) of the transverse-sigmoid sinus causing trigeminal neuralgia is presented. Although progression to almost continuous facial pain has been reported, symptoms may be indistinguishable from typical trigeminal neuralgia. The patient had a 6-year history of right-sided trigeminal neuralgia initially well controlled by medical management. He was referred for surgical management after 10 months of progressively worsening of symptoms. At the time of consultation, the patient complained of pulsatile tinnitus in the right ear. Computed tomography imaging and angiography demonstrated a DAVF involving the right transverse-sigmoid sinus junction with retrograde venous drainage. Surgical resection of the DAVF provided both angiographic cure and complete relief of all symptoms. The authors discuss the pathophysiology of trigeminal neuralgia in patients with a DAVF. C1 [de Paula Lucas, C.] Inst Neurol Goiania, Dept Neurol & Neurosurg, BR-74210250 Goiania, Go, Brazil. [Zabramski, J. M.] St Josephs Hosp, Barrow Neurol Inst, Div Neurol Surg, Phoenix, AZ 85013 USA. [Zabramski, J. M.] Med Ctr, Phoenix, AZ USA. RP Lucas, CD (reprint author), Inst Neurol Goiania, Dept Neurol & Neurosurg, Praca T18,140 Setor Bueno, BR-74210250 Goiania, Go, Brazil. 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PD DEC PY 2007 VL 149 IS 12 BP 1249 EP 1253 DI 10.1007/s00701-007-1367-y PG 5 WC Clinical Neurology; Surgery SC Neurosciences & Neurology; Surgery GA 240WE UT WOS:000251618100021 ER PT J AU Miyashita, T Hoshikawa, H Kagawa, M Mori, N AF Miyashita, Takenori Hoshikawa, Hiroshi Kagawa, Masahiro Mori, Nozomu TI A case report of facial nerve hemangioma SO AURIS NASUS LARYNX LA English DT Review DE facial nerve; hemangioma; geniculate ganglion; facial palsy ID INTRATEMPORAL VASCULAR TUMORS; TEMPORAL BONE HEMANGIOMAS; MANAGEMENT AB Facial nerve hemangioma is a rare benign tumor that originates from the venous plexus surrounding the facial nerve. A case of facial nerve hemangioma in the geniculate ganglion was reported. A 47-year-old man was referred with a left progressive facial palsy over 1 year. There were no complaints of associated hearing loss, tinnitus, headache, dizziness or otalgia. He had a left-side grade VI (House and Brackmann) facial palsy. Audiometry revealed normal hearing thresholds in conversation area bilaterally. CT imaging demonstrated a tumor at the left first germ of the facial nerve with expansion to the cochlea wall and middle skull base. MRI imaging demonstrated a centrally enhancing lesion measuring 5 mm x 10 mm in the geniculate ganglion. The tumor was totally removed by the middle cranial fossa approach. At the time of surgery the facial nerve was destroyed by the tumor in the geniculate ganglion. Histopathological examination diagnosed a hemangioma. (c) 2007 Published by Elsevier Ireland Ltd. C1 [Miyashita, Takenori; Hoshikawa, Hiroshi; Mori, Nozomu] Kagawa Univ, Fac Med, Dept Otolaryngol, Miki, Kagawa 7610793, Japan. [Kagawa, Masahiro] Kagawa Univ, Fac Med, Dept Neurosurg, Miki, Kagawa 7610793, Japan. RP Miyashita, T (reprint author), Kagawa Univ, Fac Med, Dept Otolaryngol, 1750-1 Ikenobe, Miki, Kagawa 7610793, Japan. 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Miller, Steven M. Fitzgerald, Paul B. TI The use of tDCS and CVS as methods of non-invasive brain stimulation SO BRAIN RESEARCH REVIEWS LA English DT Review DE transcranial direct current stimulation; caloric vestibular stimulation; brain stimulation; transcranial magnetic stimulation; stroke; mood disorder ID TRANSCRANIAL MAGNETIC STIMULATION; HUMAN MOTOR CORTEX; CALORIC VESTIBULAR STIMULATION; POSITRON-EMISSION-TOMOGRAPHY; NECK MUSCLE VIBRATION; CORTICAL SPREADING DEPRESSION; UNILATERAL SPATIAL NEGLECT; OPTOKINETIC STIMULATION; DC-STIMULATION; PREFRONTAL CORTEX AB Transcranial direct current stimulation (tDCS) and caloric vestibular stimulation (CVS) are safe methods for selectively modulating cortical excitability and activation, respectively, which have recently received increased interest regarding possible clinical applications. tDCS involves the application of low currents to the scalp via cathodal and anodal electrodes and has been shown to affect a range of motor, somatosensory, visual, affective and cognitive functions. Therapeutic effects have been demonstrated in clinical trials of tDCS for a variety of conditions including tinnitus, post-stroke motor deficits, fibromyalgia, depression, epilepsy and Parkinson's disease. Its effects can be modulated by combination with pharmacological treatment and it may influence the efficacy of other neurostimulatory techniques such as transcranial magnetic stimulation. CVS involves irrigating the auditory canal with cold water which induces a temperature gradient across the semicircular canals of the vestibular apparatus. This has been shown in functional brain-imaging studies to result in activation in several contralateral cortical and subcortical brain regions. CVS has also been shown to have effects on a wide range of visual and cognitive phenomena, as well as on post-stroke conditions, mania and chronic pain states. Both these techniques have been shown to modulate a range of brain functions, and display potential as clinical treatments. Importantly, they are both inexpensive relative to other brain stimulation techniques such as electroconvulsive therapy (ECT) and transcranial magnetic stimulation (TMS). (C) 2007 Elsevier B.V. All rights reserved. C1 Alfred Hosp, Alfred Psychiat Res Ctr, Melbourne, Vic 3004, Australia. [Been, Gregory; Ngo, Trung T.; Miller, Steven M.; Fitzgerald, Paul B.] Monash Univ, Sch Psychol Psychiat & Psychol Med, Melbourne, Vic 3004, Australia. [Ngo, Trung T.; Miller, Steven M.] Caulfield Gen Med Ctr, Caulifield Pain Management & Res Ctr, Melbourne, Vic 3162, Australia. RP Fitzgerald, PB (reprint author), Alfred Hosp, Alfred Psychiat Res Ctr, Commercial Rd, Melbourne, Vic 3004, Australia. 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Rev. PD DEC PY 2007 VL 56 IS 2 BP 346 EP 361 DI 10.1016/j.brainresrev.2007.08.001 PG 16 WC Neurosciences SC Neurosciences & Neurology GA 248SW UT WOS:000252176700005 PM 17900703 ER PT J AU Faag, C Bergenius, J Forsberg, C Langius-Eklof, A AF Faag, C. Bergenius, J. Forsberg, C. Langius-Eklof, A. TI Symptoms experienced by patients with peripheral vestibular disorders: evaluation of the Vertigo Symptom Scale for clinical application SO CLINICAL OTOLARYNGOLOGY LA English DT Article ID QUALITY-OF-LIFE; MENIERES-DISEASE; DIZZY PATIENTS; DIZZINESS; COHERENCE; HANDICAP; ATTACKS; HEALTH; SENSE AB Objectives: To describe symptoms during an episode of dizziness in a sample of patients suffering from peripheral vestibular disorders and to compare them with the items in the Vertigo Symptom Scale. Design: A descriptive study from a sample of patients with peripheral vestibular disorders. Setting: Patients visiting a department of audiology at a university hospital. Participants: Twenty patients with peripheral vestibular disorders. The inclusion criteria were that the patient had had at least three spontaneous attacks of vertigo and/or was constantly unsteady during the last 3 months for at least 75% of the time when awake. Main outcome measure: Patients were instructed to complete a diary where they recorded symptoms that arose during an episode of dizziness. These symptoms were compared with the content of the Vertigo Symptom Scale. Results: The most frequent symptoms as mentioned by the patients in their diaries were a feeling that things are spinning or moving around, nausea, feeling unsteady/about to lose one's balance, fatigue, headache, a feeling as if the ground you walk on is distant and ear-related such as tinnitus and a feeling of pressure in the ear. Pain in the heart or chest region, a heavy feeling in the arms or legs, pain in the lower part of the back and excessive sweating were not mentioned at all or by very few patients. Analysis showed that some of the symptoms included in the Vertigo Symptom Scale occurred less during an episode of dizziness than others in this sample of patients with peripheral vestibular disorders. Conclusion: It was found that the Vertigo Symptom Scale is an adequate base but may need to be developed for use in patients diagnosed with peripheral vestibular symptoms to be able to evaluate care and treatment. C1 Red Cross Univ, Coll Nursing, SE-11428 Stockholm, Sweden. Karolinska Hosp & Inst, Dept Clin Neurosci, Stockholm, Sweden. Red Cross Univ, Coll Nursing, Dept Mol Med & Surg, Stockholm, Sweden. Red Cross Univ, Coll Nursing, Dept Neurobiol, Care Sci Soc, Stockholm, Sweden. RP Faag, C (reprint author), Red Cross Univ, Coll Nursing, Teknikringen 1, SE-11428 Stockholm, Sweden. 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Otolaryngol. PD DEC PY 2007 VL 32 IS 6 BP 440 EP 446 PG 7 WC Otorhinolaryngology SC Otorhinolaryngology GA 237ZC UT WOS:000251414800004 PM 18076429 ER PT J AU Ibekwe, TS Ijaduola, GTA AF Ibekwe, T. S. Ijaduola, G. T. A. TI Meniere's disease: rare or underdiagnosed among Africans SO EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY LA English DT Article DE Meniere's disease; endolymphatic hydrop; prevalence; audiology ID PREVALENCE AB Meniere's disease can easily be misdiagnosed because several otological disorders mimic the disease. Conflicting reports on the incidence of this disease among the Africans had been documented. The goal of our study was to verify the prevalence and clinical features of Meniere's disease in WA sub-region. A 10 year (1996-2005) retrospective study carried out in our hospital. The diagnostic criteria for the disease were outlined and Oyedeji's social classification instrument was adapted for socio-economic stratification of patients. The method of treatment and prognostic out-come were discussed. Out of 11,463 patients seen within the period, 25 (16 females and 9 males) met the diagnostic criteria for Meniere's disease. The age ranged from 27 to 75 years (mean = 47.2 SD13.2) and the most predominant age group was 41-50 years. Sixty-eight percent were of low socio-economic class and the rest high. About 84% had unilateral and 16% bilateral Meniere's disease. All the patients presented with tinnitus, vertigo and audiologically confirmed sensorineural hearing loss. CT-scan and MRI were used to rule out some differentials, while caloric and recruitment tests were used to strengthen the diagnosis. Treatment regimen (conservative) outcome: 72% had good improvement, 8% fair, while 20% absconded from follow-up. The prevalence of Meniere's disease in West African sub-region is 0.22%. This prevalence among Africans may not differ from the Caucasians. Under- or over-diagnosis of the disease previously must have been responsible for the contrasting results. Appropriate diagnostic tools are necessary for accurate diagnosis of the disease. C1 Univ Ibadan, Coll Med, Univ Coll Ibadan Hosp, Dept Otorhinolaryngol, Ibadan, Nigeria. RP Ibekwe, TS (reprint author), Univ Ibadan, Coll Med, Univ Coll Ibadan Hosp, Dept Otorhinolaryngol, Ibadan, Nigeria. EM ibekwets@yahoo.com CR *AM AC OT HEAD NEC, 2006, MEN DIS BANERJEE AS, 2006, J LARYNGOL OTOL, V17, P1 BLACK RJ, 1982, J LARYNGOL OTOL, V96, P847, DOI 10.1017/S002221510009318X BROBBY GW, 1992, GHANA MED J, V26, P454 Choung YH, 2006, J LARYNGOL OTOL, V120, P343, DOI 10.1017/S0022215106000569 Convert C, 2006, OTOL NEUROTOL, V27, P687, DOI 10.1097/01.mao.0000227661.52760.f1 da Costa SS, 2002, OTOLARYNG CLIN N AM, V35, P455, DOI 10.1016/S0030-6665(02)00028-2 DHINGRA PL, 2004, DIS EAR NOSE THROAT, P28 ERBEK SH, 2006, VERTIGO CHILDHOOD CL Havia M, 2005, OTOLARYNG HEAD NECK, V133, P762, DOI 10.1016/j.otohns.2005.06.015 House JW, 2006, OTOL NEUROTOL, V27, P355, DOI 10.1097/00129492-200604000-00011 JAMES M, 1998, JAMA-J AM MED ASSOC, V279, P486 KLAR J, 2006, AM J MED GENET B LOPEZ LP, 2006, ACTA OTORRINILARRING, V56, P125 LUTHMAN ME, 1997, SCOTT BROWNS OTORHIN MOFFAT DA, 1997, SCOTT BROWN OTOLARYN Mouadeb DA, 2005, LARYNGOSCOPE, V115, P879, DOI 10.1097/01.MLG.0000158666.15447.37 OKAFOR BC, 1984, J LARYNGOL OTOL, V98, P775, DOI 10.1017/S0022215100147449 Onuki J, 2005, ANN OTO RHINOL LARYN, V114, P927 OYEDEJI G A, 1985, Nigerian Journal of Paediatrics, V12, P111 ROWLAND NJ, 2001, KEY TOPICS OTOLARYNG, P27 Shepard NT, 2006, J AM ACAD AUDIOL, V17, P69, DOI 10.3766/jaaa.17.1.7 SOJAKU H, 2005, ORL J OTORHINOLARYNG, V67, P305 WATANABE I, 1983, MENIERES DIS COMPREH, P16 NR 24 TC 2 Z9 2 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013 USA SN 0937-4477 J9 EUR ARCH OTO-RHINO-L JI Eur. Arch. Oto-Rhino-Laryn. PD DEC PY 2007 VL 264 IS 12 BP 1399 EP 1403 DI 10.1007/s00405-007-0377-y PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA 224JA UT WOS:000250442100003 PM 17610076 ER PT J AU Acar, GO Acioglu, E Enver, O Ar, C Sahin, S AF Acar, Guel Oezbilen Acioglu, Engin Enver, Oezguen Ar, Cem Sahin, Serap TI Unilateral sudden hearing loss as the first sign of chronic myeloid leukemia SO EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY LA English DT Article DE chronic myeloid leukemia; sudden hearing loss; deafness; vertigo; intratympanic steroid therapy ID CHRONIC MYELOGENOUS LEUKEMIA; CHRONIC LYMPHOCYTIC-LEUKEMIA; HYPERVISCOSITY SYNDROME; MANIFESTATION; DEAFNESS AB Chronic myeloid leukemia (CML) is one of the etiologic causes of sudden hearing loss and vertigo. However, deafness in association with vestibular symptoms rarely occurs in CML as the first sign. In this article, a 50-year-old male with CML whose first signs and symptoms were unilateral sudden hearing loss and tinnitus in the right ear, vertigo and nausea was presented. Aetiopathogenetic mechanisms, clinical and radiological aspects and therapeutic options for CML with deafness and vertigo were discussed reviewing the literature. C1 Istanbul Univ, Dept Otorhinolaryngol, Cerrahpasa Med Sch, Istanbul, Turkey. Istanbul Univ, Dept Internal Med, Div Hematol, Cerrahpasa Med Sch, Istanbul, Turkey. RP Acar, GO (reprint author), Ata 3-4,D 249,Sedef Caddesi Atasehir, Istanbul, Turkey. EM gulozbilenacar@gmail.com CR ANDRES E, 2001, CLIN LAB HAEMATOL, V23, P7 BAER MR, 1985, CANCER, V56, P2865, DOI 10.1002/1097-0142(19851215)56:12<2865::AID-CNCR2820561225>3.0.CO;2-6 Chae SW, 2002, J LARYNGOL OTOL, V116, P291 Chim CS, 1997, LEUKEMIA LYMPHOMA, V26, P209 GENDEN EM, 1995, OTOLARYNG HEAD NECK, V113, P499, DOI 10.1016/S0194-5998(95)70095-1 GOTAY V, 1976, LARYNGOSCOPE, V86, P1856 KANYIKE FB, 1982, E AFR MED J, V59, P420 Naithani R, 2005, PEDIATR BLOOD CANCER, V45, P54, DOI 10.1002/pbc.20211 PAPARELL.MM, 1973, LARYNGOSCOPE, V83, P1510, DOI 10.1288/00005537-197309000-00010 PRESTON FE, 1978, BRIT MED J, V25, P76 RESENDE LS, 2000, ACTA HAEMATOL, V104, P6 Veling MC, 1999, OTOLARYNG HEAD NECK, V120, P954, DOI 10.1016/S0194-5998(99)70349-9 WILLIAMS CKO, 1985, BRIT MED J, V290, P1705 YAMADA K, 1994, ACTA OTO-LARYNGOL, V114, P586, DOI 10.3109/00016489409126110 NR 14 TC 4 Z9 4 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013 USA SN 0937-4477 J9 EUR ARCH OTO-RHINO-L JI Eur. Arch. Oto-Rhino-Laryn. PD DEC PY 2007 VL 264 IS 12 BP 1513 EP 1516 DI 10.1007/s00405-007-0382-1 PG 4 WC Otorhinolaryngology SC Otorhinolaryngology GA 224JA UT WOS:000250442100021 PM 17610073 ER PT J AU Hoang, BX Shaw, DG Pham, PT Levine, SA AF Hoang, Ba X. Shaw, David G. Pham, Phuong T. Levine, Stephen A. TI Neurobiological effects of melatonin as related to cancer SO EUROPEAN JOURNAL OF CANCER PREVENTION LA English DT Article DE cancer pathogenesis; cancer prevention; excitotoxins; melatonin; membrane calming; membrane excitability; nutrition; sedatives ID PINEAL HORMONE MELATONIN; METASTATIC BREAST-CANCER; LOW-DOSE INTERLEUKIN-2; CORE BODY-TEMPERATURE; PLUS MELATONIN; NEUROHORMONE MELATONIN; ESTROGEN-RECEPTOR; SOLID NEOPLASMS; TUMOR PATIENTS; NITRIC-OXIDE AB Melatonin is a neurohormone naturally found in humans. Melatonin plays a role in maintaining sleep-wake rhythms; supplementation may help to regulate sleep disturbance that occur with jet lag, rotating shift-work and depression. Preliminary study of melatonin has shown potential for use in the treatment of epilepsy, tinnitus, migraine and neurodegenerative diseases. The latest publication in the Journal of Pineal Research by Edward Mills and colleagues has shown a compelling role of melatonin for the treatment of cancer. Melatonin's consistent relationship with cancer has been shown in many studies assessing links between shift work and cancer rates. High levels of melatonin have been linked to slower cancer progression. How melatonin affects cancer remains largely unclear. Although previous studies suggest different possible mechanisms, many of them are far distant from the primary physiological role of melatonin as a neurohormone. Conflicting studies are found on the role of melatonin in neurodegenerative diseases and cancer. In this article, we try to build and substantiate a neurobiological concept for the anticancer effects of melatonin. C1 USC, Allergy Res Grp, San Jose, CA 95117 USA. 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J. Cancer Prev. PD DEC PY 2007 VL 16 IS 6 BP 511 EP 516 PG 6 WC Oncology SC Oncology GA 227WW UT WOS:000250689500004 PM 18090123 ER PT J AU Mazurek, B Stover, T Haupt, H Gross, J Szczepek, A AF Mazurek, B. Stover, T. Haupt, H. Gross, J. Szczepek, A. TI The role of cochlear neurotransmitters in tinnitus SO HNO LA German DT Article DE tinnitus; pathogenesis; neurotransmission; cochlea; drug therapy ID PLACEBO-CONTROLLED TRIAL; INNERVATION; CAROVERINE; THERAPY AB Pathologic changes in the cochlear neurotransmission, e. g. as a result of intensive noise exposure or ototoxic drugs, can be a factor in the development of tinnitus. The efficiency of inhibitory and excitatory neurotransmitters may then be modulated at the switching points. Glutamate is the most important afferent neurotransmitter within the inner ear. A massive glutamate release induced by cochlear damage may result in excitotoxicity and irrevocable cell death. Efferent cochlear neurotransmitters include dopamine, gammaaminobutyric acid ( GABA), acetylcholine (ACH) and serotonin. Dopamine and GABA are inhibitory transmitters that may protect the cochlea from excitotoxicity. ACH, like GABA, reduces the stiffness hair cells and increases their motility. Serotonin is a neuromodulator of the cholinergic and GABAergic innervation within the cochlea and can inhibit glutamatergic impulses. Our understanding of neurotransmission in the cochlea has been extended by advances in molecular biology, which has given rise to new approaches in the treatment of tinnitus. As there are several types of tinnitus, differing in aetiology and development, our present challenge is to achieve precise identification of the cause in individual cases of tinnitus. C1 Univ Med Berlin, Charite, HNO Klin & Poliklin, Tinnituszentrum, D-10117 Berlin, Germany. Med Hochsch, HNO Klin & Poliklin, Hannover, Germany. RP Mazurek, B (reprint author), Univ Med Berlin, Charite, HNO Klin & Poliklin, Tinnituszentrum, Chariteplatz 1, D-10117 Berlin, Germany. 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R., 2006, HEARING ANATOMY PHYS, V2 López González M A, 2003, Acta Otorrinolaringol Esp, V54, P237 OESTREICHER E, 2004, LOKALE APPL MEMANTIN Puel JL, 1995, PROG NEUROBIOL, V47, P449, DOI 10.1016/0301-0082(95)00028-3 Raphael Y, 2003, BRAIN RES BULL, V60, P397, DOI 10.1016/S0361-9230(03)00047-9 Robinson SK, 2005, PSYCHOSOM MED, V67, P981, DOI 10.1097/01.psy.0000188479.04891.74 Ruel J, 2007, HEARING RES, V227, P19, DOI 10.1016/j.heares.2006.08.017 Shemen L, 1998, OTOLARYNG HEAD NECK, V118, P421, DOI 10.1016/S0194-5998(98)70332-8 Shulman Abraham, 2002, Int Tinnitus J, V8, P30 Shulman A, 2000, Int Tinnitus J, V6, P98 Simpson JJ, 2000, HEARING RES, V145, P1, DOI 10.1016/S0378-5955(00)00093-9 Westerberg BD, 1996, AM J OTOL, V17, P896 Zapp J J, 2001, Ear Nose Throat J, V80, P114 NR 30 TC 9 Z9 11 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013 USA SN 0017-6192 J9 HNO JI HNO PD DEC PY 2007 VL 55 IS 12 BP 964 EP 971 DI 10.1007/s00106-007-1624-7 PG 8 WC Otorhinolaryngology SC Otorhinolaryngology GA 237NO UT WOS:000251381700010 PM 17943261 ER PT J AU Chang, HP Chou, P AF Chang, Hsin-Pin Chou, Pesus TI Preshycusis among older Chinese people in Taipei, Taiwan: A community-based study SO INTERNATIONAL JOURNAL OF AUDIOLOGY LA English DT Article DE aged; presbycusis; Taiwan; hearing aids; Chinese ID HEARING-LOSS; EPIDEMIOLOGY; IMPAIRMENT; PREVALENCE; VERTIGO; PRESBYCUSIS; POPULATION; TINNITUS; COHORT; ADULTS AB The purpose of this study was to estimate the prevalence and severity of presbycusis in older Chinese people in Taipei, Taiwan. Pure-tone audiometry and a questionnaire were administered to a randomly-recruited cohort of people > 65 years old (n=1221) from a community in Taipei. The study cohort showed pure-tone thresholds worsening, especially at frequencies > 2 kHz, with increasing age. The mean pure-tone average at speech frequencies (0.5, 1, and 2 kHz) of the better ear of subjects stratified by five-year age groups ranged from 34.9 dB hearing level (HL) to 46.4 dB HL. The pure-tone average at speech frequency in women was slightly higher than that in men in all age groups. The prevalence of presbycusis (M3 >= 55 dBHL) was 1.6% (65 - 69 years), 3.2% (70 - 74 years), 7.5% (75 - 79 years), and 14.9% (>= 80 years). Persistent tinnitus was present in 13.9% of subjects, and 18.8% of subjects had a history of vertigo. Of subjects with a clinically evident hearing impairment (M3 >= 55 dBHL), 18.4% used hearing aids. These data provide estimates of the prevalence and severity of presbycusis in community-dwelling older persons in Taiwan. C1 [Chang, Hsin-Pin; Chou, Pesus] Natl Yang Ming Univ, Inst Publ Hlth, Taipei 112, Taiwan. [Chang, Hsin-Pin; Chou, Pesus] Natl Yang Ming Univ, Community Med Res Ctr, Taipei 112, Taiwan. [Chang, Hsin-Pin] Taipei City Hosp, Dept Otolaryngol, Yang Ming Branch, Taipei, Taiwan. RP Chou, P (reprint author), Natl Yang Ming Univ, Inst Publ Hlth, 155,Sec 2,Linong St, Taipei 112, Taiwan. 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J. Audiol. PD DEC PY 2007 VL 46 IS 12 BP 738 EP 745 DI 10.1080/14992020701558529 PG 8 WC Audiology & Speech-Language Pathology; Otorhinolaryngology SC Audiology & Speech-Language Pathology; Otorhinolaryngology GA 245ZN UT WOS:000251977400003 PM 18049963 ER PT J AU Kato, S Ishihara, H Nakayama, H Fujii, M Fujisawa, H Kajiwara, K Nomura, S Sadanaga, H Suzuki, M AF Kato, S. Ishihara, H. Nakayama, H. Fujii, M. Fujisawa, H. Kajiwara, K. Nomura, S. Sadanaga, H. Suzuki, M. TI Transvenous embolization for dural arteriovenous shunt of the cavernous sinus - Comparison of multi-staged transvenous embolization and transvenous embolization with sinus packing SO INTERVENTIONAL NEURORADIOLOGY LA English DT Article DE arteriovenous shunt; cavernous sinus; multi-staged embolization ID FISTULAS AB We describe the treatment and follow-up clinical symptoms and angiographic results in patients with dural arteriovenous fistula of the cavernous sinus treated by transvenous embolization (TVE). We have treated eight cases of dural arteriovenous fistula of the cavernous sinus by multi-staged TVE in two cases and TVE with sinus packing in six and three of six cases were treated with a combination of transarterial embolization. Multi-staged TVE was performed by occlusion from dangerous drainage veins to the cavernous sinus on several occasions. Angiographical results showed disappearance or reduction of the arteriovenous shunt in all cases. Six patients presented with ophthalmic symptoms and two had tinnitus. Six cases had complete disappearance of clinical symptoms after treatment. There was a deterioration of ocular movement in one patient treated by TVE with sinus packing. Multi-staged TVE was performed to reduce the coil volume for the packing of the cavernous sinus in two cases without cranial nerve palsy. Embolization, especially multi-staged TVE, was considered a good treatment to occlude arteriovenous shunts at the cavernous sinus without cranial nerve complications. C1 [Kato, S.; Ishihara, H.; Nakayama, H.; Fujii, M.; Fujisawa, H.; Kajiwara, K.; Nomura, S.; Suzuki, M.] Yamaguchi Univ, Sch Med, Dept Neurosurg, Yamaguchi 7558505, Japan. RP Kato, S (reprint author), Yamaguchi Univ, Sch Med, Dept Neurosurg, 1-1-1 Minamikogushi, Yamaguchi 7558505, Japan. EM skato@yamaguchi-u.ac.jp CR DEBRUN GM, 1988, NEUROSURGERY, V22, P285 Guo WY, 1998, AM J NEURORADIOL, V19, P1081 HALBACH VV, 1989, AM J NEURORADIOL, V10, P143 HALBACH VV, 1991, AM J NEURORADIOL, V12, P319 Klisch J, 2003, NEUROSURGERY, V53, P836, DOI 10.1227/01.NEU.0000083551.26295.AB UFLACKER R, 1986, RADIOLOGY, V159, P175 VINUELA F, 1984, J NEUROSURG, V60, P976, DOI 10.3171/jns.1984.60.5.0976 NR 7 TC 0 Z9 1 PU EDIZIONI CENTAURO PI BOLOGNA PA VIA DEL PRATELLO, 8, 40122 BOLOGNA, ITALY SN 1123-9344 J9 INTERV NEURORADIOL JI Interv. Neuroradiol. PD DEC PY 2007 VL 13 IS 4 BP 353 EP 358 PG 6 WC Clinical Neurology; Radiology, Nuclear Medicine & Medical Imaging SC Neurosciences & Neurology; Radiology, Nuclear Medicine & Medical Imaging GA 274VK UT WOS:000254030500006 PM 20566104 ER PT J AU Ison, JR Allen, PD O'Neill, WE AF Ison, James R. Allen, Paul D. O'Neill, William E. TI Age-related hearing loss in C57BL/6J mice has both frequency-specific and non-frequency-specific components that produce a hyperacusis-like exaggeration of the acoustic startle reflex SO JARO-JOURNAL OF THE ASSOCIATION FOR RESEARCH IN OTOLARYNGOLOGY LA English DT Article DE aging; hearing loss; startle; plasticity; mixed strial; sensory presbycusis; tinnitus; hyperacusis ID HAIR CELL LOSS; AUDITORY-CORTEX; PREPULSE INHIBITION; COCHLEAR NUCLEUS; TONOTOPIC MAP; PLASTICITY; MOUSE; DEGENERATION; TINNITUS; SENSITIVITY AB Auditory brainstem-evoked response (ABR) thresholds were obtained in a longitudinal study of C57BL/6J mice between 10 and 53 weeks old, with repeated testing every 2 weeks. On alternate weeks, acoustic startle reflex (ASR) amplitudes were measured, elicited by tone pips with stimulus frequencies of 3, 6, 12, and 24 kHz, and intensities from subthreshold up to 110 dB sound pressure level. The increase in ABR thresholds for 3 and 6 kHz test stimuli followed a linear time course with increasing age from 10 to 53 weeks, with a slope of about 0.7 dB/week, and for 48 kHz a second linear time course, but beginning at 10 weeks with a slope of about 2.3 dB/week. ABR thresholds for 12, 24, and 32 kHz increased after one linear segment with a 0.7 dB slope, then after a variable delay related to the test frequency, shifted to a second segment having slopes of 3-5 dB/week. Hearing loss initially reduced the ASR for all eliciting stimuli, but at about 6 months of age, the response elicited by intense 3 and 6 kHz stimuli began to increase to reach values about three times above normal, and previously subthreshold stimuli came to elicit vigorous responses seen at first only for the intense stimuli. This hyperacusis-like effect appeared in all mice but was especially pronounced in mice with more serious hearing loss. These ABR data, together with a review of histopathological data in the C57BL/6 literature, suggest that the non-frequency-specific slow time course of hearing loss results from pathology in the lateral wall of the cochlea, whereas the stimulus-specific hearing loss with a rapid time course results from hair cell loss. Delayed exaggeration of the ASR with hearing loss reveals a deficit in centrifugal inhibitory control over the afferent reflex pathways after central neural reorganization, suggesting that this mouse may provide a useful model of age-related tinnitus and associated hyperacusis. C1 Univ Rochester, Dept Brain & Cognit Sci, Rochester, NY 14627 USA. Univ Rochester, Med Ctr, Dept Neurobiol & Anat, Rochester, NY 14642 USA. RP Ison, JR (reprint author), Univ Rochester, Dept Brain & Cognit Sci, Meliora Hall, Rochester, NY 14627 USA. 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Taylor, Christopher L. Yonas, Howard TI Treatment of dural arteriovenous fistula using ethylene vinyl alcohol (Onyx) arterial embolization as the primary modality: short-term results SO JOURNAL OF NEUROSURGERY LA English DT Article DE arteriovenous fistula; cerebrovascular location; dura mater; embolization; endovascular treatment; Onyx ID SUPERIOR SAGITTAL SINUS; TRANSVERSE-SIGMOID SINUS; TRANSARTERIAL EMBOLIZATION; STEREOTACTIC RADIOSURGERY; CAVERNOUS SINUS; FOLLOW-UP; MALFORMATIONS; MANAGEMENT; SURGERY AB Object. A dural arteriovenous fistula (DAVF) typically involves meningeal feeding arteries and can cause clinical symptoms ranging from tinnitus to rupture of draining cortical or parenchymal veins. Surgical treatment may be technically demanding. Ethylene vinyl alcohol (Onyx, ev3 Neurovascular) has several properties that make it potentially useful as a primary treatment agent for DAVF. Onyx is expected to be a permanent embolic agent. It should have a decreased risk of catheter retention when compared with other permanent embolic materials. Methods. The authors report a series of six patients with symptomatic DAVF who were treated initially with transarterial Onyx embolization and other endovascular techniques. Results. Five patients had complete occlusion of their DAVF noted on the follow-up angiograrn obtained between 2 and 4 months. One patient had residual filling via a small arterial branch that was stable on follow-up angiography. None of the patients had worsening of neurological function. One case was complicated by a retained catheter fragment. Conclusions. Transarterial Onyx embolization and other endovascular methods can angiographically obliterate DAVF. In some cases, embolization allowed occlusion of multiple arterial feeding arteries from a single arterial injection. Technically, the embolization was optimized when a microcatheter position immediately adjacent to the point(s) of fistulization was achieved. C1 [Carlson, Andrew P.; Taylor, Christopher L.; Yonas, Howard] Univ New Mexico, Dept Neurosurg, Albuquerque, NM 87131 USA. [Taylor, Christopher L.] Univ New Mexico, Dept Radiol, Albuquerque, NM USA. RP Taylor, CL (reprint author), Univ New Mexico, Dept Neurosurg, Albuquerque, NM 87131 USA. EM ctaylor@salud.unm.edu RI Carlson, Andrew/B-4369-2012 OI Carlson, Andrew/0000-0003-2189-3699 CR ARAT A, 2006, NEUROSURGERY, V59, pSE170 Bertalanffy A, 2001, MINIM INVAS NEUROSUR, V44, P205, DOI 10.1055/s-2001-19932 Cekirge HS, 2006, NEURORADIOLOGY, V48, P113, DOI 10.1007/s00234-005-0007-6 Friedman JA, 2001, J NEUROSURG, V94, P886, DOI 10.3171/jns.2001.94.6.0886 Guo WY, 1998, AM J NEURORADIOL, V19, P1081 Kawaguchi S, 2000, J CLIN NEUROSCI, V7, P47 Kawaguchi T, 2000, NEUROL MED-CHIR, V40, P366, DOI 10.2176/nmc.40.366 Kim MS, 2002, J CLIN NEUROSCI, V9, P147, DOI 10.1054/jocn.2001.1029 Kiyosue H, 2004, RADIOGRAPHICS, V24, P1637, DOI 10.1148/rg.246045026 LEWIS AI, 1994, J NEUROSURG, V81, P851, DOI 10.3171/jns.1994.81.6.0851 Nelson PK, 2003, J NEUROSURG, V98, P498, DOI 10.3171/jns.2003.98.3.0498 O'Leary S, 2002, CLIN ONCOL-UK, V14, P97, DOI 10.1053/clon.2002.0072 Pan DHC, 2002, J NEUROSURG, V96, P823, DOI 10.3171/jns.2002.96.5.0823 Pollock BE, 1999, NEUROSURGERY, V45, P459, DOI 10.1097/00006123-199909000-00008 Rezende MTS, 2006, NEURORADIOLOGY, V48, P130, DOI 10.1007/s00234-005-0020-9 Roy D, 1997, NEUROSURGERY, V40, P1133, DOI 10.1097/00006123-199706000-00004 Satomi J, 2002, J NEUROSURG, V97, P767, DOI 10.3171/jns.2002.97.4.0767 Toulgoat F, 2006, J NEURORADIOLOGY, V33, P105, DOI 10.1016/S0150-9861(06)77239-X van Dijk JMC, 2002, STROKE, V33, P1578, DOI 10.1161/01.STR.0000018009.83713.06 VANDIJK M, 2002, STROKE, V33, P1233 NR 20 TC 39 Z9 40 PU AMER ASSOC NEUROLOGICAL SURGEONS PI ROLLING MEADOWS PA 5550 MEADOWBROOK DRIVE, ROLLING MEADOWS, IL 60008 USA SN 0022-3085 J9 J NEUROSURG JI J. Neurosurg. PD DEC PY 2007 VL 107 IS 6 BP 1120 EP 1125 DI 10.3171/JNS-07/12/1120 PG 6 WC Clinical Neurology; Surgery SC Neurosciences & Neurology; Surgery GA 239LP UT WOS:000251520100008 PM 18077948 ER PT J AU Lee, CY Jaw, FS Pan, SL Lin, MY Young, YH AF Lee, Chung-Yi Jaw, Fu-Shan Pan, Shin-Liang Lin, Meng-Yi Young, Yi-Ho TI Auditory cortical evoked potentials in tinnitus patients with normal audiological presentation SO JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION LA English DT Article DE auditory cortical evoked potentials; edge frequency; intensity dependence; problem-tinnitus; tinnitus ID MAGNETIC-FIELDS; HEARING-LOSS; REORGANIZATION; INHIBITION; PLASTICITY; INTENSITY; TRAUMA AB Background/Purpose: It is widely assumed that damage to the peripheral hearing system is an essential prerequisite for the occurrence of tinnitus. However, previous studies have failed to target tinnitus patients with normal hearing. This study aims to investigate if tinnitus patients with normal audiological presentation demonstrate increased intensity dependence at the selected frequencies. Methods: This study applied auditory cortical evoked potential test to investigate nine tinnitus patients with normal audiological presentation and nine age- and sex-matched healthy subjects without tinnitus. Auditory cortical evoked potentials (N1-P2) were elicited from stimuli at four frequencies (4000, 2000, 1000 and 500 Hz) with five intensities (50, 56, 62, 68 and 74 dB nHL). Intensity dependences by latency of N I and amplitude of N1-P2 were surveyed at midline electrodes. Results: The results showed that the intensity dependence by latency of N1 to the pooled frequencies at three midline electrodes, e.g. Fz, Cz and Pz, revealed non-significant difference. However, significant differences existed in the intensity dependence of amplitude N1-P2 to the pooled frequencies at the Fz and Cz positions. These differences suggested that tinnitus patients tended to respond less to increased sound intensity and were inclined to weaker intensity dependence. Conclusion: Increased intensity dependence of N1-P2 component at the selected frequencies cannot be demonstrated in tinnitus patients with normal hearing. Restated, the edge frequency phenomenon fails to present in tinnitus patients with normal hearing, a different characteristic from tinnitus patients with hearing loss. C1 [Lee, Chung-Yi; Young, Yi-Ho] Natl Taiwan Univ Hosp, Dept Otolaryngol, Taipei, Taiwan. [Lee, Chung-Yi; Jaw, Fu-Shan; Lin, Meng-Yi] Natl Taiwan Univ, Coll Med, Inst Biomed Engn, Taipei, Taiwan. [Lee, Chung-Yi; Jaw, Fu-Shan; Lin, Meng-Yi] Natl Taiwan Univ, Coll Engn, Inst Biomed Engn, Taipei, Taiwan. RP Young, YH (reprint author), Natl Taiwan Univ Hosp, Dept Otolaryngol, 1 Chang Te St, Taipei, Taiwan. 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Formos. Med. Assoc. PD DEC PY 2007 VL 106 IS 12 BP 979 EP 985 DI 10.1016/S0929-6646(08)60072-8 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA 246YG UT WOS:000252043700001 PM 18194902 ER PT J AU Psillas, G Constantinidis, J Triaridis, S Vital, V AF Psillas, G. Constantinidis, J. Triaridis, S. Vital, V. TI Acute unilateral total deafness and vestibular findings after gunshot noise SO LARYNGO-RHINO-OTOLOGIE LA English DT Article DE acoustic trauma; gunshot; noise; hearing loss; caloric test; VEMP ID ACUTE ACOUSTIC TRAUMA; IMPULSE NOISE; HEARING-LOSS; GUINEA-PIGS; DAMAGE; POTENTIALS; EXPOSURE; GUNFIRE AB Acute Unilateral Total Deafness and Vestibular Findings after Gunshot Noise Background: Acute acoustic trauma is usually acquired during military service after exposure to impulse or blast wave noise. The typical audiometric shape is a notch centered at about 4 kHz with some recovery above this frequency. This is the first case of an immediate induced unilateral total hearing loss in a young soldier following exposure to gunfire noise. Case report: A 25-year-old right-hander army officer during military training, after realizing a series of five shots with a rifle (G3), he immediately experienced on the right ear otalgia, tinnitus and severe hearing loss, without imbalance or dizziness. The pure tone audiogram revealed a cophosis on the right ear without any residual remnants. In order to estimate the extent of the labyrinth damage, a caloric test and vestibular evoked myogenic potentials (VEMPs) were performed, which were both abnormal. Conclusion: The possible mechanical and metabolic damage effects on the cochlea from the intense gunfire noise were discussed. As the caloric test showed directional preponderance and the VEMPs were totally abolished, it has been concluded that the saccule and to a lesser degree the posterior labyrinth have been also found affected. The importance of wearing hearing protectors such as ear plugs and ear muffs during exposure to intense noise was underlined. C1 [Psillas, G.; Constantinidis, J.; Triaridis, S.; Vital, V.] Aristotle Univ Thessaloniki, AHEPA Hosp, Hals Nasen Ohren Klin Kopf & Halschirurg, Thessaloniki, Greece. RP Constantinidis, J (reprint author), Aristotle Univ Thessaloniki, HNO Klin Kopf & Halschirurg, Klinikum AHEPA, Thessaloniki 54006, Greece. EM janconst@otenet.gr CR ALBERTI PW, 1997, S BROWNS OTOLARYNGOL, V2, P1 AXELSSON A, 1987, HEARING RES, V31, P183, DOI 10.1016/0378-5955(87)90125-0 AXELSSON A, 1987, ACTA OTO-LARYNGOL, V104, P225, DOI 10.3109/00016488709107322 BOHNE BA, 1983, HEARING RES, V11, P41, DOI 10.1016/0378-5955(83)90044-8 COLEBATCH JG, 1992, NEUROLOGY, V42, P1635 Forrest M R, 1982, Scand Audiol Suppl, V16, P7 Golz A, 2001, AM J OTOLARYNG, V22, P190, DOI 10.1053/ajot.2001.23428 HAMERNIK RP, 1984, HEARING RES, V13, P229, DOI 10.1016/0378-5955(84)90077-7 Iwasaki S, 2005, ARCH OTOLARYNGOL, V131, P857, DOI 10.1001/archotol.131.10.857 LAMM K, 1989, HNO, V37, P48 Lonsbury-Martin BL, 1998, OTOLARYNGOLOGY HEAD, V4, P3153 MAN A, 1980, J LARYNGOL OTOL, V94, P1395, DOI 10.1017/S0022215100090228 MANGABEIRA-ALBERNAZ P L, 1959, Laryngoscope, V69, P1478 McCABE B F, 1958, Acta Otolaryngol, V49, P147, DOI 10.3109/00016485809134738 Metternich FU, 1999, LARYNGO RHINO OTOL, V78, P614 PERLMAN H B, 1962, Acta Otolaryngol, V54, P99, DOI 10.3109/00016486209126927 Plontke S, 2003, HNO, V51, P245, DOI 10.1007/s00106-003-0808-z PLONTKE SK, 2004, LARYNGO RHINO OT S1, V83, P122 SALMIVALLI A, 1979, ACTA OTO-LARYNGOL, P96 Sendowski I, 2006, ACTA OTO-LARYNGOL, V126, P122, DOI 10.1080/00016480500312547 SHUPAK A, 1994, ACTA OTO-LARYNGOL, V114, P579, DOI 10.3109/00016489409126109 YLIKOSKI J, 1987, ACTA OTO-LARYNGOL, V103, P415 YLIKOSKI J, 1987, SCAND AUDIOL, V16, P115, DOI 10.3109/01050398709042165 YLIKOSKI J, 1988, ACTA OTO-LARYNGOL, V105, P558, DOI 10.3109/00016488809119520 YLIKOSKI J, 1988, AM J OTOL, V9, P282 YLIKOSKI ME, 1994, SCAND J WORK ENV HEA, V20, P93 NR 26 TC 0 Z9 1 PU GEORG THIEME VERLAG KG PI STUTTGART PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY SN 0935-8943 J9 LARYNGO RHINO OTOL JI Laryngo-Rhino-Otol. PD DEC PY 2007 VL 86 IS 12 BP 879 EP 882 DI 10.1055/s-2007-966576 PG 4 WC Otorhinolaryngology SC Otorhinolaryngology GA 239VG UT WOS:000251545800009 PM 17594611 ER PT J AU Miller, VL Stewart, M Lehman, M AF Miller, Vanessa L. Stewart, Michael Lehman, Mark TI Noise exposure levels for student musicians SO MEDICAL PROBLEMS OF PERFORMING ARTISTS LA English DT Article ID ORCHESTRAL MUSICIANS; HEARING; TINNITUS; CRITERIA; OSHA AB Twenty-seven student musicians were surveyed regarding musical practice and playing habits, knowledge of hearing conservation practices, use of hearing protective devices (HPD), and the occurrence of tinnitus after exposure to loud music. In addition, noise exposure levels during practice and sporting events (football and basketball games) at which they played were monitored with a dosimeter simultaneously set to measure noise levels using the OSHA (1983) and NIOSH (1998) measurement criteria. Forty-eight percent of the subjects reported practicing or playing their instrument > 10 hours a week. Most musicians (74%) reported having been taught about the effects of noise on hearing and health; however, less than a third used ear protection while playing their instruments, and those who did used it inconsistently. Sixty-three percent of subjects reported experiencing tinnitus after exposure to loud music. Finally, 8-hour time-weighted averages (TWA) and daily noise doses were significantly higher using the NIOSH measurement criteria than the OSHA measurement criteria. Both measurement criteria yielded values that exceeded a 100% daily noise dose for all subjects. Overall, these results indicate that university student directors and musicians appear to be at high risk for permanent noise-induced hearing loss secondary to excessive exposure to loud music. These results support the need for on-going hearing conservation programs to educate student musicians and student directors about the dangers of excessive exposure to loud music. C1 [Miller, Vanessa L.; Stewart, Michael; Lehman, Mark] Cent Michigan Univ, Mt Pleasant, MI 48859 USA. RP Stewart, M (reprint author), Cent Michigan Univ, Hlth Proffes Bldg 2172, Mt Pleasant, MI 48859 USA. 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PD DEC PY 2007 VL 22 IS 4 BP 160 EP 165 PG 6 WC Medicine, General & Internal; Music SC General & Internal Medicine; Music GA 250TY UT WOS:000252325000006 ER PT J AU Liu, YX Zhang, HL Li, XP Wang, YL Lu, H Qi, X Ma, CS Liu, JX AF Liu, Yanxing Zhang, Hailin Li, Xuepei Wang, Yongli Lu, Hong Qi, Xiang Ma, Changsheng Liu, Junxiu TI Inhibition of voltage-gated channel currents in rat auditory cortex neurons by salicylate SO NEUROPHARMACOLOGY LA English DT Article DE salicylate; voltage-gated sodium channel current; delayed rectifier potassium channel current; L-type voltage-gated calcium channel current; auditory cortex ID INFERIOR COLLICULUS NEURONS; HIPPOCAMPAL-NEURONS; CALCIUM-CHANNELS; ANIMAL-MODEL; C-FOS; TINNITUS; SODIUM; ACTIVATION; OUTWARD AB Salicylate is a medicine for anti -inflammation with a side effect of tinnitus. To understand the mechanisms of tinnitus induced by salicylate, we studied the effects of salicylate on voltage-gated ion channels and action potential firing rates in freshly dissociated rat pyramidal neurons in auditory cortex (AC) using the whole-cell patch technique. We found that salicylate reduced the voltage-gated sodium Current (I-Na), the delayed rectifier potassium current (I-K(DR)) and the L-type voltage-gated calcium current (I-CA,I-I.) in concentration-dependent manner. An amount of 1 mM salicylate shifted the steady-state inactivation curve Of INa negatively by about 5 mV, shifted the steady-state activation and inactivation curve of I-K(DR) negatively by approximately 14 mV and 17 mV, respectively, and shifted the steady-state activation curve of I-CA,I-I. negatively by about 10 mV. 1 mM salicylate significantly increased the action potential firing rates, ultimately, From the results, we speculated that through affecting the voltage-gated ion channels in AC, an important position in auditory system. salicylate increased the firing rate of neurons and enhanced neuronal excitability on the one hand, increased the excitatory transmitters release and reduced the inhibitory transmitter release on the other hand, thus finally induced tinnitus. (c) 2007 Elsevier Ltd. All rights reserved. C1 [Liu, Yanxing; Zhang, Hailin; Wang, Yongli; Ma, Changsheng] Hebei Med Univ, Dept Pharmacol & Neurobiol, Shijiazhuang 050017, Hubei, Peoples R China. [Li, Xuepei; Liu, Junxiu] Peking Univ, Hosp 3, Dept Otorhinolaryngol, Beijing 100083, Peoples R China. [Lu, Hong] Hebei Med Univ Second Hosp, Dept Otorhinolaryngol, Shijiazhuang 050000, Hebei, Peoples R China. [Qi, Xiang] Hebei Med Univ Second Hosp, Dept Anesthesiol, Shijiazhuang 050000, Hebei, Peoples R China. RP Liu, YX (reprint author), Hebei Med Univ, Dept Pharmacol & Neurobiol, 361 Zhongshan E Rd, Shijiazhuang 050017, Hubei, Peoples R China. 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Gaggl, Wolfgang Runge-Samuelson, Christina Ulmer, John L. Kopell, Brian Harris TI Feasibility of auditory cortical stimulation for the treatment of tinnitus SO OTOLOGY & NEUROTOLOGY LA English DT Article DE auditory cortex; cortical stimulation; implant; suppression; tinnitus ID TRANSCRANIAL MAGNETIC STIMULATION; SUPPRESSION; MECHANISMS; CORTEX AB Objectives: To investigate the feasibility and safety of an implantable epidural cortical stimulator for the treatment of severe tinnitus. Study Design: Prospective, controlled, single-blinded study of cortical stimulation for 4 weeks, and then an open-label stimulation period. Setting: Tertiary care referral center. Patients: Adults (n = 8) with constant tinnitus of at least I year with a tinnitus reaction questionnaire score greater than 33. Tinnitus was predominantly unilateral with a frequency less than 8,000 Hz. Interventions: Surgical implantation of an investigational epidural electrode over the posterior superior temporal gyrus using functional magnetic resonance imaging targeting. A 2-week stimulation period alternated with a 2-week sham period in random order to which subjects were blinded. This was followed by continuous stimulation with parameter adjustments to maximize tinnitus suppression. Main Outcome Measure: Subjective rating of tinnitus severity, loudness, and device efficacy. Objective measures of hearing thresholds, tinnitus frequency, loudness, and minimum masking levels. Outcome measures using the Tinnitus Handicap Questionnaire, Tinnitus Reaction Questionnaire, and Beck Depression Inventory. Results: There were no effects of stimulation during the 4-week blinded period. With continuous chronic stimulation, 2 patients had persistent reduction of pure-tone tinnitus, and 6 patients had short periods of total tinnitus suppression. Significant improvements in the Beck Depression Inventory and tinnitus questionnaires were found, although objective measures of tinnitus loudness remained fairly stable. No surgical or stimulation-related complications were noted. Conclusion: Chronic electrical stimulation of the secondary auditory cortex seems safe and warrants further investigation as a potential therapeutic intervention for the suppression of tinnitus. C1 Med Coll Wisconsin, Clement J Zablocki VA Med Ctr, Dept Otolaryngol & Commun Sci, Milwaukee, WI USA. Med Coll Wisconsin, Clement J Zablocki VA Med Ctr, Dept Radiol, Milwaukee, WI USA. Med Coll Wisconsin, Clement J Zablocki VA Med Ctr, Dept Neurosurg, Milwaukee, WI USA. RP Friedland, DR (reprint author), Med Coll Wisconsin, Dept Otolaryngol & Commun Sci, Milwaukee, WI 53226 USA. EM dfriedla@mcw.edu CR AXELSSON A, 1989, British Journal of Audiology, V23, P53, DOI 10.3109/03005368909077819 Bartels H, 2007, STEREOT FUNCT NEUROS, V85, P150, DOI 10.1159/000099073 Cox RW, 1996, COMPUT BIOMED RES, V29, P162, DOI 10.1006/cbmr.1996.0014 De Ridder D, 2005, OTOL NEUROTOL, V26, P616, DOI 10.1097/01.mao.0000178146.91139.3c De Ridder D, 2006, ORL J OTO-RHINO-LARY, V68, P48, DOI 10.1159/000090491 Fenoy AJ, 2006, BRAIN RES, V1118, P75, DOI 10.1016/j.brainres.2006.08.013 FOLMER RL, 2006, ACTA OTO-LARYNGOL, V556, P96 Fregni F, 2006, EUR J NEUROL, V13, P996, DOI 10.1111/j.1468-1311.2006.01414.x Hall DA, 1999, HUM BRAIN MAPP, V7, P213, DOI 10.1002/(SICI)1097-0193(1999)7:3<213::AID-HBM5>3.0.CO;2-N HAZELL JWP, 1990, J OTOLARYNGOL, V19, P1 Henry JA, 2005, J SPEECH LANG HEAR R, V48, P1204, DOI 10.1044/1092-4388(2005/084) HENRY JA, 2006, ACTA OTO-LARYNGOL, V556, P64 Kleinjung T, 2005, OTOLARYNG HEAD NECK, V132, P566, DOI 10.1016/j.otohns.2004.09.134 Langguth B, 2006, ACTA OTO-LARYNGOL, V556, P102 Moller AR, 2006, PROG BRAIN RES, V157, P365, DOI 10.1016/S0079-6123(06)57022-0 Patterson Matthew B, 2006, Int Tinnitus J, V12, P149 Rubinstein JT, 2003, OTOL NEUROTOL, V24, P478, DOI 10.1097/00129492-200305000-00021 NR 17 TC 42 Z9 43 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1531-7129 J9 OTOL NEUROTOL JI Otol. Neurotol. PD DEC PY 2007 VL 28 IS 8 BP 1005 EP 1012 PG 8 WC Clinical Neurology; Otorhinolaryngology SC Neurosciences & Neurology; Otorhinolaryngology GA 237FF UT WOS:000251358900003 PM 18043428 ER PT J AU Lao, WW Niparko, JK AF Lao, William W. Niparko, John K. TI Assessment of changes in cochlear function with pneumolabyrinth after middle ear trauma SO OTOLOGY & NEUROTOLOGY LA English DT Article DE acute heating loss; acute vertigo; aural fullness; penetrating injury; perilymph fistula; pneumolabyrinth; sensorineural; hearing loss; tinnitus ID TEMPORAL BONE-FRACTURE AB Objective: To describe a case of pneumolabyrinth secondary to tympanic membrane/ossicular trauma and the subsequent recovery of sensorineural hearing loss managed with conservative measures. Patients: A 15-year-old boy presented to an outside hospital with signs and symptoms of acute hearing loss, vertigo, and tinnitus after penetrating injury to his right tympanic membrane. In addition, computed tomography demonstrated air density within the vestibule. Interventions: The patient was managed conservatively with bed rest, avoidance of straining, corticosteroids, and antibiotics. Main Outcome Measures: Computed tomography, audiologic testing. Results: Patient recovered near-normal hearing subjectively. There was closure of the air-bone gap (520 dB) along with resolution of air within vestibule. Conclusion: We presented a case of a patient with pneumolabyrinth secondary to penetrating trauma to his tympanic membrane. With supportive treatment, air within the labyrinth resorbed, and the patient recovered sensorineural function. Comparing with the mixed successes of surgical repairs, we propose that initial management for traumatic pneurnolabyrinth should be first treated conservatively in the absence of worsening symptoms. C1 Johns Hopkins Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, Baltimore, MD USA. RP Niparko, JK (reprint author), Johns Hopkins Univ, Dept Otolaryngol Head & Neck Surg, 601 N Caroline St, Baltimore, MD 21287 USA. 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Neurotol. PD DEC PY 2007 VL 28 IS 8 BP 1013 EP 1017 PG 5 WC Clinical Neurology; Otorhinolaryngology SC Neurosciences & Neurology; Otorhinolaryngology GA 237FF UT WOS:000251358900004 PM 18043429 ER PT J AU Teufert, KB Berliner, KI De la Cruz, T AF Teufert, Karen B. Berliner, Karen I. De la Cruz, Tantonio TI Persistent dizziness after surgical treatment of vertigo: An exploratory study of prognostic factors SO OTOLOGY & NEUROTOLOGY LA English DT Article; Proceedings Paper CT 140th Annual Meeting of the American-Otological-Society CY APR 27-28, 2007 CL San Diego, CA SP Amer Otol Soc DE imbalance; Meniere's disease; prognostic factors; surgical treatment of vertigo; vertigo ID VESTIBULAR NERVE-SECTION; MENIERES-DISEASE; TRANSMASTOID LABYRINTHECTOMY; INTRATYMPANIC GENTAMICIN; MANAGEMENT; PREVALENCE AB Objective: Persistent vertigo and imbalance can occur after surgery for vertigo regardless of surgical approach. This study explored for factors affecting outcome of vertigo surgery. Study Design: Patient survey and chart review. Setting: Tertiary referral neurotologic private practice. Patients/Intervention: Of 111 patients (57.7% female; mean age, 52.3 yr), 59 underwent vestibular nerve section (middle fossa, retrolabyrinthine, and translabyrinthine), 25 underwent transmastoid labyrinthectomy, and 27 underwent endolymphatic sac shunt. Eighty-three percent had Meniere's disease. Mean follow-up was 4.3 years. Main Outcome Measures: Primary outcomes included American Academy of Otolaryngology-Head and Neck Surgery (AAO-HNS) vertigo score and class, number of spells per month, current and change in AAO-HNS disability rating, vertigo and imbalance severity ratings, and frequency of imbalance. Results: Three preoperative factors were consistently related to outcome: AAO-HNS disability rating, imbalance frequency rating, and duration of first symptom (p = 0.19-0.51; all p's < 0.05). Greater disability and more frequent imbalance related to poorer outcome, but longer duration of disease related to better outcome. Presurgery vertigo characteristics were generally not related to outcome. Meniere's patients were more likely to have improvement in imbalance, as were those with no other significant disease and no allergy. The presence of tinnitus in the contralateral ear was associated with poorer outcomes, including a lower rate of results of Classes A and B (p = 0.023). Vertigo as a first symptom and the presence of eye disease also showed relationships to poorer outcome. Conclusion: Those rating themselves as more disabled before surgery are less likely to achieve the best outcomes, whereas frequency and severity of preoperative vertigo are not predictive. Several possible prognostic factors were identified that warrant future prospective study. C1 House Ear Res Inst, Los Angeles, CA 90057 USA. House Clin, Los Angeles, CA USA. RP De la Cruz, T (reprint author), House Ear Res Inst, c-o Clin Stud Dept,2100 W 3rd St,5th Fl, Los Angeles, CA 90057 USA. 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Neurotol. PD DEC PY 2007 VL 28 IS 8 BP 1056 EP 1062 PG 7 WC Clinical Neurology; Otorhinolaryngology SC Neurosciences & Neurology; Otorhinolaryngology GA 237FF UT WOS:000251358900014 PM 18084816 ER PT J AU Ramirez, LM Ballesteros, LE Sandoval, GP AF Ramirez, Luis Miguel Ballesteros, Luis Ernesto Sandoval, German Pablo TI Otological symptoms among patients with temporomandibular joint disorders SO REVISTA MEDICA DE CHILE LA Spanish DT Review DE dizziness; temporomandibular joint disorders; tinnitus ID TENSOR VELI-PALATINI; DILATATOR TUBAE MUSCLES; MIDDLE-EAR MYOCLONUS; PULSATILE TINNITUS; TYMPANI MUSCLE; MORPHOLOGY; VERTIGO; DISEASE; REFLEX; UNIT AB Middle ear muscles have a common embryological and functional origin with masticatory and facial muscles. Therefore, symptoms referred to the ear may originate from the stomatognathic area. When a primary otological cause is discarded in the diagnostic work up for tinnitus, vertigo, hypoacousia, hyperacousia, ear pain or sensation of occluded ear, a temporoinandibular joint dysfunction may be the cause of these symptoms. Temporomandibular joint dysfunction is twice more common among women and has environmental, physiological and behavioral causes. Among patients with this dysfunction, the prevalence of ear pain, tinnitus and dizziness varies between 33 and 76% (Rev Med Chile 2007; 135: 1582-90). C1 [Ramirez, Luis Miguel; Ballesteros, Luis Ernesto] Univ Ind Santander, Dept Ciencias Basicas, Bucaramanga, Colombia. [Sandoval, German Pablo] Univ Ind Santander, Dept Cirug, Bucaramanga, Colombia. RP Ramirez, LM (reprint author), Univ Ind Santander, Dept Ciencias Basicas, Bucaramanga, Colombia. 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Medica Chile PD DEC PY 2007 VL 135 IS 12 BP 1582 EP 1590 PG 9 WC Medicine, General & Internal SC General & Internal Medicine GA 260ER UT WOS:000252994100013 PM 18357361 ER PT J AU Ganesh, A Rose, JB Wells, L Ganley, T Gurnaney, H Maxwell, LG DiMaggio, T Milovcich, K Scollon, M Feldman, JM Cucchiaro, G AF Ganesh, Arjunan Rose, John B. Wells, Lawrence Ganley, Theodore Gurnaney, Harshad Maxwell, Lynne G. DiMaggio, Theresa Milovcich, Karen Scollon, Maureen Feldman, Jeffrey M. Cucchiaro, Giovanni TI Continuous peripheral nerve blockade for inpatient and outpatient postoperative analgesia in children SO ANESTHESIA AND ANALGESIA LA English DT Article ID BRACHIAL-PLEXUS BLOCK; PAIN-CONTROL; COMPARTMENT SYNDROME; REGIONAL ANESTHESIA; ORTHOPEDIC-SURGERY; SHOULDER SURGERY; RANDOMIZED-TRIAL; HOME; INFUSION; REHABILITATION AB This is an audit of the continuous peripheral nerve blockade (CPNB) program that was implemented at our institution to provide postoperative analgesia after orthopedic procedures in children. METHODS: We reviewed the departmental regional anesthesia registry and the medical records of consecutive children who received CPNB for postoperative analgesia at The Children's Hospital of Philadelphia between February 2003 and July 2006. Patients were prospectively followed until cessation of the effects of CPNB and/or resolution of any related complications. Data collected contemporaneously included presence of sensory and motor blockade, pain scores in inpatients, opioid administration, and complications related to CPNB. RESULTS: A total of 226 peripheral nerve catheters were placed in 217 patients. One hundred eight patients (112 catheters) were discharged home with CPNB. The ages ranged from 4 to 18 yr (13.7 +/- 3.4). Local anesthetic solution (0.125% bupivacaine [n = 1641], 0.1% ropivacaine [n = 12], or 0.15% ropivacaine [n = 27]) was infused at an initial rate of 2-12 mL/h based on patients' weights and locations of catheters. The mean duration of local anesthetic infusion was 48.4 +/- 29.3 h (range 0-160 h). The percentage of patients who did not require any opioids in the first 8, 24, and 48 h after surgery was 56%, 26%, and 21%, respectively. The incidence of nausea and vomiting was 14% (13% in outpatients, 15% in inpatients). Complications were noted in 2.8% of patients. Three patients had prolonged numbness (>24 h) that resolved spontaneously; one developed superficial cellulitis that resolved with a course of antibiotics; one had difficulty removing the catheter at home and one developed tinnitus 24 h after starting CPNB that resolved quickly after clamping of the catheter followed by removal. CONCLUSION: It is feasible to implement a CPNB program to provide an alternative method of inpatient and outpatient postoperative analgesia after orthopedic surgery in children when appropriate expertise is available. Patient and family education along with frequent follow-up are crucial to detect and address adverse events promptly. (Anesth Analg 2007;105:1234-42) C1 Childrens Hosp Philadelphia, Dept Anesthesiol & Crit Care Med, Philadelphia, PA 19104 USA. Univ Penn, Sch Med, Philadelphia, PA 19104 USA. Childrens Hosp Philadelphia, Dept Orthoped, Philadelphia, PA 19104 USA. RP Ganesh, A (reprint author), Childrens Hosp Philadelphia, Dept Anesthesiol & Crit Care Med, 34th St & Civ Ctr Blvd, Philadelphia, PA 19104 USA. EM ganesha@email.chop.edu CR Benumof JL, 2000, ANESTHESIOLOGY, V93, P1541, DOI 10.1097/00000542-200012000-00033 Boezaart André P, 2002, Best Pract Res Clin Anaesthesiol, V16, P295, DOI 10.1053/bean.2002.0239 Borgeat A, 1997, ANESTHESIOLOGY, V87, P1343, DOI 10.1097/00000542-199712000-00013 Capdevila X, 2006, ANESTHESIOLOGY, V105, P566, DOI 10.1097/00000542-200609000-00022 Capdevila X, 1999, ANESTHESIOLOGY, V91, P8, DOI 10.1097/00000542-199907000-00006 Capdevila X, 2005, ANESTHESIOLOGY, V103, P1035, DOI 10.1097/00000542-200511000-00018 Cucchiaro G, 2007, ANESTH ANALG, V104, P532, DOI 10.1213/01.ane.0000253548.97479.b8 Dadure C, 2007, ANN FR ANESTH, V26, P136, DOI 10.1016/j.annfar.2006.10.016 Dadure C, 2005, ANESTHESIOLOGY, V102, P387, DOI 10.1097/00000542-200502000-00022 Dadure C, 2003, ANESTH ANALG, V97, P687, DOI 10.1213/01.ANE.0000074348.78109.79 Dunwoody JM, 1997, J PEDIATR ORTHOPED, V17, P285, DOI 10.1097/00004694-199705000-00003 Evans Holly, 2005, Anesthesiol Clin North America, V23, P141, DOI 10.1016/j.atc.2004.11.003 Giaufre E, 1996, ANESTH ANALG, V83, P904, DOI 10.1097/00000539-199611000-00003 Grant SA, 2001, REGION ANESTH PAIN M, V26, P209, DOI 10.1053/rapm.2001.22256 Ilfeld BM, 2002, ANESTHESIOLOGY, V96, P1297, DOI 10.1097/00000542-200206000-00006 Ilfeld BM, 2002, ANESTHESIOLOGY, V97, P959, DOI 10.1097/00000542-200210000-00031 Ilfeld Brian M, 2004, Am J Orthop (Belle Mead NJ), V33, P405 Ilfeld BM, 2003, ANESTH ANALG, V96, P1089, DOI 10.1213/01.ANE.0000049824.51036.EF JOHNSON CM, 1994, ANAESTH INTENS CARE, V22, P281 Klein SM, 2000, ANESTH ANALG, V91, P1473, DOI 10.1097/00000539-200012000-00033 LARSSON S, 1995, ACTA ANAESTH SCAND, V39, P539 Merkel S I, 1997, Pediatr Nurs, V23, P293 Paut O, 2001, ANESTH ANALG, V92, P1159 Ross AK, 2000, ANESTH ANALG, V91, P16, DOI 10.1097/00000539-200007000-00004 Ross O, 1999, ANAESTHESIA, V54, P297, DOI 10.1046/j.1365-2044.1999.0811a.x Sciard D, 2001, ANESTHESIOLOGY, V95, P1521, DOI 10.1097/00000542-200112000-00036 Singelyn FJ, 1999, ANESTH ANALG, V89, P1216 Soeding PF, 2005, ANAESTH INTENS CARE, V33, P719 TOBIAS JD, 1994, ANAESTH INTENS CARE, V22, P616 NR 29 TC 34 Z9 35 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0003-2999 J9 ANESTH ANALG JI Anesth. Analg. PD NOV PY 2007 VL 105 IS 5 BP 1234 EP 1242 DI 10.1213/01.ane.0000284670.17412.66 PG 9 WC Anesthesiology SC Anesthesiology GA 222SN UT WOS:000250317500013 PM 17959949 ER PT J AU Bortoli, R Santiago, M AF Bortoli, Rodrigo Santiago, Mittermayer TI Chloroquine ototoxicity SO CLINICAL RHEUMATOLOGY LA English DT Review DE chloroquine; ototoxicity ID HYDROXYCHLOROQUINE AB Chloroquine (CQ), a 4-aminoquinoline drug, has been largely used for the treatment of rheumatoid arthritis and other connective tissue diseases. Besides the well-known retinal toxicity, its use has been suspected of be associated to ototoxicity. Some reports have described mainly sensorineural hearing loss, tinnitus, sense of imbalance, and cochleovestibular manifestations. Differently from what occurs in retinopathy, in which there is a predominance of CQ toxicity, there are reports of alterations in hearing related to either CQ or hydroxychloroquine. Brain-evoked response audiometry seems to be the most sensitive test in detecting early manifestations of cochlear injury caused by CQ when still in a reversible stage. The reversibility of CQ ototoxicity has been debatable, but there is suggestion that such complication can be corrected if the medication is stopped and appropriate therapy, with steroids and plasma expanders, is instituted. C1 HSI, Serv Reumatol, BR-40000000 Bahia Blanca, Brazil. Escola Bahiana Med & Saude Publ, Salvador, BA, Brazil. RP Santiago, M (reprint author), HSI, Serv Reumatol, Praca Conselheiro Almeida Couto 500, BR-40000000 Bahia Blanca, Brazil. EM mitter@svn.com.br CR BERNARD P, 1985, ACTA OTO-LARYNGOL, V99, P387, DOI 10.3109/00016488509108928 Hadi U, 1996, OTOLARYNG HEAD NECK, V114, P491, DOI 10.1016/S0194-5998(96)70226-7 HART CW, 1964, ARCHIV OTOLARYNGOL, V80, P407 Johansen PB, 1998, CLIN EXP RHEUMATOL, V16, P472 MATZ GJ, 1968, ARCH OTOLARYNGOL, V88, P370 MUKHERJEE DK, 1979, J LARYNGOL OTOL, V93, P809, DOI 10.1017/S0022215100087740 MUKHERJEE DK, 1978, NIGERIAL MED J, V3, P20 PAGE F, 1951, Lancet, V2, P755 Roverano S, 2006, JCR-J CLIN RHEUMATOL, V12, P217, DOI 10.1097/01.rhu.0000242777.71604.69 Rynes RI, 1997, BRIT J RHEUMATOL, V36, P799 SCHERBEL A L, 1958, Cleve Clin Q, V25, P95 Seckin U, 2000, RHEUMATOL INT, V19, P203, DOI 10.1007/s002960000054 NR 12 TC 5 Z9 5 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013 USA SN 0770-3198 J9 CLIN RHEUMATOL JI Clin. Rheumatol. PD NOV PY 2007 VL 26 IS 11 BP 1809 EP 1810 DI 10.1007/s10067-007-0662-6 PG 2 WC Rheumatology SC Rheumatology GA 215MU UT WOS:000249813700002 PM 17594118 ER PT J AU Krause, E Hempel, JM Gurkov, R AF Krause, Eike Hempel, John Martin Guerkov, Robert TI Vertigo caused by a nasopharyngeal carcinoma SO EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY LA English DT Article DE labyrinth dysfunction; skull base tumor; hearing loss; tinnitus; eustachian tube AB A case of a 63 year-old woman with acute vertigo, hearing loss and tinnitus caused by a nasopharyngeal carcinoma is reported. Despite a long-standing unilateral Eustachian tube dysfunction, only the occurrence of vertigo attacks lead to the diagnosis in this patient. Inner ear-related symptoms are rare in nasopharyngeal carcinoma and the disease is uncommon in Europe. Skull base tumors are an important differential diagnosis of labyrinth dysfunction that can be detected by MRI. A complete diagnostic work-up is necessary in patients with unilateral tube dysfunction, to allow early detection of this disorder. C1 Univ Munich, Dept Otorhinolaryngol, D-81377 Munich, Germany. RP Krause, E (reprint author), Univ Munich, Dept Otorhinolaryngol, Marchioninistr 15, D-81377 Munich, Germany. EM eike.krause@med.uni-muenchen.de RI Gurkov, Robert/K-3536-2013 OI Gurkov, Robert/0000-0002-4195-149X CR Huang TW, 2002, OTOL NEUROTOL, V23, P975, DOI 10.1097/00129492-200211000-00027 Lee A. W. M., 1997, Hong Kong Medical Journal, V3, P355 Parkin DM, 2005, CA-CANCER J CLIN, V55, P74 Shanmugaratnam K, 1991, INT HISTOLOGICAL CLA, P32 Wei WI, 2005, LANCET, V365, P2041, DOI 10.1016/S0140-6736(05)66698-6 NR 5 TC 1 Z9 1 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013 USA SN 0937-4477 J9 EUR ARCH OTO-RHINO-L JI Eur. Arch. Oto-Rhino-Laryn. PD NOV PY 2007 VL 264 IS 11 BP 1381 EP 1383 DI 10.1007/s00405-007-0365-2 PG 3 WC Otorhinolaryngology SC Otorhinolaryngology GA 215BC UT WOS:000249781400020 PM 17588167 ER PT J AU Ceylan, A Celenk, F Kemaloglu, YK Bayazit, YA Goksu, N Ozbilen, S AF Ceylan, A. Celenk, F. Kemaloglu, Y. K. Bayazit, Y. A. Goeksu, N. Oezbilen, S. TI Impact of prognostic factors on recovery from sudden hearing loss SO JOURNAL OF LARYNGOLOGY AND OTOLOGY LA English DT Article DE sudden hearing loss; sensorineural deafness; prognosis ID DOUBLE-BLIND; DEAFNESS; DIAGNOSIS; INDICATOR; CARBOGEN; EFFICACY; STEROIDS; CRITERIA; THERAPY; PLACEBO AB Objective: To define the impact of patient-related and audiovestibular parameters on the prognosis of sudden hearing loss. Methods: Eighty-three patients were included in this retrospective study. All were treated medically. We recorded the patients' demographic parameters, systemic diseases, time elapsed between onset of sudden hearing loss and initiation of treatment, tinnitus, vestibular symptoms, type of initial audiogram, pure tone averages and speech discrimination scores. For all patients, audiological measurements were performed on initial admission and at the completion of treatment on the 10th day. Results: There was no correlation between the hearing gain and recovery rate scores and patients' gender or age (p > 0.05). However, a correlation was found between gender and relative hearing gain. Vertigo was not correlated with hearing gain and recovery rate scores (p < 0.05). However, relative hearing gain correlated negatively with the presence of vertigo (-r = 0.05, 81 degrees of freedom, p = 0.043). Patients with < 40 dB hearing loss on admission showed a better relative hearing gain (r = 0.55, 81 degrees of freedom, p = 0.03). Relative hearing gain correlated positively with better pre-treatment speech discrimination scores (r = 0.82, 81 degrees of freedom, p = 0.009) and negatively with poorer pre-treatment pure tone averages (-r = 0.082, 81 degrees of freedom, p = 0.009). There was no correlation between the scores for hearing gain, relative hearing gain and recovery rate and: systemic diseases (p > 0.05); time elapsed between onset of sudden hearing loss and initiation of treatment (p > 0.05); type of audiogram on initial admission (p > 0.05), except for midfrequency type of audiogram; and tinnitus (p > 0.05). Conclusions: The outcome of sudden hearing loss was unaffected by systemic disease, tinnitus or type of audiogram (except for midfrequency type). The following were poor prognostic factors in the outcome of sudden hearing loss: female gender, presence of vertigo, initiation of treatment more than seven days after onset of hearing loss, and > 40 dB hearing loss on admission. 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Laryngol. Otol. PD NOV PY 2007 VL 121 IS 11 BP 1035 EP 1040 PG 6 WC Otorhinolaryngology SC Otorhinolaryngology GA 242KF UT WOS:000251723300005 PM 17241495 ER PT J AU Lerut, B De Vuyst, C Ghekiere, J Vanopdenbosch, L Kuhweide, R AF Lerut, B. De Vuyst, C. Ghekiere, J. Vanopdenbosch, L. Kuhweide, R. TI Post-traumatic pulsatile tinnitus: the hallmark of a direct carotico-cavernous fistula SO JOURNAL OF LARYNGOLOGY AND OTOLOGY LA English DT Article; Proceedings Paper CT Conference of the Royal-Belgian-Society-of-Otorhinolaryngology-Head-and-Neck-Surgery CY MAY 20, 2006 CL Louvain, BELGIUM SP Royal Belgian Soc Otorhinolaryngol, Head & Neck Surg DE pulsatile tinnitus; arteriovenous fistula; internal carotid artery; cavernous sinus ID DURAL ARTERIOVENOUS-FISTULAS; SINUS FISTULAS; COMPLICATIONS; ANGIOGRAPHY; DIAGNOSIS AB Following trauma to her right frontal region, a 68-year-old woman suffered bilateral, benign, paroxysmal, positional vertigo and a left-sided, longitudinal petrosal bone fracture, with secondary facial palsy and ossicular luxation. From the onset, the patient complained of pulsatile, left-sided tinnitus. After eight weeks, she developed left-sided ocular symptoms, progressing from conjunctival hyperaemia and orbital oedema to an abducens nerve palsy, and ultimately to heart failure. The case and the final diagnosis of carotico-cavernous fistula are discussed. Guidelines are proposed for a diagnostic approach to pulsatile tinnitus and for the optimal management of patients presenting with pulsatile tinnitus associated with ocular symptoms. C1 [Lerut, B.; Kuhweide, R.] AZ St Jan Hosp, Dept Otolaryngol, Brugge, Belgium. [De Vuyst, C.] AZ St Jan Hosp, Dept Ophthalmol, Brugge, Belgium. [Ghekiere, J.] AZ St Jan Hosp, Dept Neuroradiol, Brugge, Belgium. [Vanopdenbosch, L.] AZ St Jan Hosp, Dept Neurol, Brugge, Belgium. RP Lerut, B (reprint author), Ruddershove 10, B-8000 Brugge, Belgium. EM boblerut@gmail.com CR BARROW DL, 1985, J NEUROSURG, V62, P248, DOI 10.3171/jns.1985.62.2.0248 Brown RD, 2005, MAYO CLIN PROC, V80, P269 de Keizer R, 2003, Orbit, V22, P121 DEBRUN G, 1981, J NEUROSURG, V55, P678, DOI 10.3171/jns.1981.55.5.0678 Duan YY, 2005, J ULTRAS MED, V24, P739 Link MJ, 1996, J NEUROSURG, V84, P804, DOI 10.3171/jns.1996.84.5.0804 Lockwood AH, 2002, NEW ENGL J MED, V347, P904, DOI 10.1056/NEJMra013395 Robertson A, 1999, J LARYNGOL OTOL, V113, P744 Schreiber SJ, 2004, AM J NEURORADIOL, V25, P775 Shin EJ, 2000, LARYNGOSCOPE, V110, P1916, DOI 10.1097/00005537-200011000-00028 Sismanis A, 2003, OTOLARYNG CLIN N AM, V36, P389, DOI 10.1016/S0030-6665(02)00169-X SPECTOR RH, 1991, AM J OPHTHALMOL, V111, P77 Waldvogel D, 1998, J NEUROL, V245, P137, DOI 10.1007/s004150050193 WAUGH JR, 1992, RADIOLOGY, V182, P243 Weissman JL, 2000, RADIOLOGY, V216, P342 Willinsky RA, 2003, RADIOLOGY, V227, P522, DOI 10.1148/radiol.2272012071 NR 16 TC 4 Z9 5 PU CAMBRIDGE UNIV PRESS PI CAMBRIDGE PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND SN 0022-2151 J9 J LARYNGOL OTOL JI J. Laryngol. Otol. PD NOV PY 2007 VL 121 IS 11 BP 1103 EP 1107 DI 10.1017/S0022215107005890 PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA 242KF UT WOS:000251723300019 PM 17295936 ER PT J AU Liu, JK Sayama, CM Shelton, C MacDonald, JD AF Liu, James K. Sayama, Christina M. Shelton, Clough MacDonald, Joel D. TI Transient facial nerve palsy after topical papaverine application during vestibular schwannoma surgery SO JOURNAL OF NEUROSURGERY LA English DT Article DE acoustic neuroma; facial nerve palsy; hearing preservation; intracisternal papaverine; vestibular schwannoma ID CEREBELLOPONTINE ANGLE SURGERY; INTERNAL AUDITORY ARTERY; INTRACISTERNAL PAPAVERINE; VASOSPASM; ISCHEMIA; CRANIOTOMY; COCHLEA; MODEL AB Some evidence in the literature supports the topical application of papaverine to the cochlear nerve to prevent internal auditory artery vasospasm and cochlear ischemia as a method of enhancing the ability to preserve hearing during acoustic neuroma surgery. The authors report a case of transient facial nerve palsy that occurred after papaverine was topically applied during a hearing preservation acoustic neuroma removal. A 58-year-old woman presented with tinnitus and serviceable sensorineural hearing loss in her right ear (speech reception threshold 15 dB, speech discrimination score 100%). Magnetic resonance imaging demonstrated a 1.5-cm acoustic neuroma in the right cerebellopontine angle (CPA). A retrosigmoid approach was performed to achieve gross-total resection of the tumor. During tumor removal, a solution of 3% papaverine soaked in a Gelfoam pledget was placed over the cochlear nerve. Shortly thereafter, the quality of the facial nerve stimulation deteriorated markedly. Electrical stimulation of the facial nerve did not elicit a response at the level of the brainstem but was observed to elicit a robust response more peripherally. There were no changes in auditory brainstem responses. Immediately after surgery, the patient had a House-Brackmann Grade V facial palsy on the tight side. After several hours, this improved to a Grade I. At the 1-month follow-up examination, the patient exhibited normal facial nerve function and stable hearing. Intracisternal papaverine may cause a transient facial nerve palsy by producing a temporary conduction block of the facial nerve. This adverse effect should be recognized when topical papaverine is used during CPA surgery. C1 Northwestern Univ, Feinberg Sch Med, Dept Neurol Surg, Evanston NW Healthcare, Evanston, IL 60201 USA. Univ Utah, Dept Neurosurg, Div Otolaryngol Head & Neck Surg, Salt Lake City, UT USA. Univ Utah, Dept Surg, Div Otolaryngol Head & Neck Surg, Salt Lake City, UT USA. RP Liu, JK (reprint author), Northwestern Univ, Feinberg Sch Med, Dept Neurol Surg, Evanston NW Healthcare, 2650 Ridge Ave, Evanston, IL 60201 USA. 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Neurosurg. PD NOV PY 2007 VL 107 IS 5 BP 1039 EP 1042 DI 10.3171/JNS-07/11/1039 PG 4 WC Clinical Neurology; Surgery SC Neurosciences & Neurology; Surgery GA 230LN UT WOS:000250878100021 PM 17977279 ER PT J AU Kasturi, S Kutikov, A Guzzo, TJ Smith, AL Wein, AJ AF Kasturi, Sanjay Kutikov, Alexander Guzzo, Thomas J. Smith, Ariana L. Wein, Alan J. TI Modern management of pheochromocytoma SO NATURE CLINICAL PRACTICE UROLOGY LA English DT Article DE adrenalectomy; adrenal gland; catecholamines; metanephrines; pheochromocytoma ID CALCIUM-CHANNEL BLOCKERS; DIAGNOSIS; ADRENALECTOMY AB Background A 55-year-old male with poorly controlled hypertension and a history of coronary artery disease presented with a large adrenal mass. The patient also reported a long-standing history of profuse sweating, tinnitus, vomiting and headaches. Investigations Physical examination, 24-hour urine metanephrine level, CT, MRI and bone scan. Diagnosis Pheochromocytoma of the left adrenal gland. Management Preoperative alpha-blockade therapy with phenoxybenzamine followed by open left adrenalectomy. C1 Univ Penn, Med Ctr, Dept Surg, Div Urol,Sch Med, Philadelphia, PA 19104 USA. Hosp Univ Penn, Philadelphia, PA 19104 USA. RP Wein, AJ (reprint author), Univ Penn, Med Ctr, Dept Surg, Div Urol,Sch Med, 9 Penn Tower,3400 Spruce St, Philadelphia, PA 19104 USA. EM alan.wein@uphs.upenn.edu RI Kutikov, Alexander/L-8707-2014 CR Amar L, 2005, J CLIN ENDOCR METAB, V90, P2110, DOI 10.1210/jc.2004-1398 Guller U, 2006, ANN SURG, V243, P102, DOI 10.1097/01.sla.0000193833.51108.24 Ilias I, 2004, HORM METAB RES, V36, P430, DOI 10.1055/s-2004-814582 Khorram-Manesh A, 2005, J INTERN MED, V258, P55, DOI 10.1111/j.1365-2796.2005.01504.x Lebuffe G, 2005, ANAESTHESIA, V60, P439, DOI 10.1111/j.1365-2044.2005.04156.x Lenders JWM, 2005, LANCET, V366, P665, DOI 10.1016/S0140-6736(05)67139-5 Lin DD, 2005, UROLOGY, V66, P476, DOI 10.1016/j.urology.2005.03.010 Moinzadeh A, 2005, J UROLOGY, V173, P519, DOI 10.1097/01.ju.0000149038.89467.30 Neumann HPH, 2002, NEW ENGL J MED, V346, P1459, DOI 10.1056/NEJMoa020152 Pacak K, 2001, ANN INTERN MED, V134, P315 PROYE C, 1989, SURGERY, V106, P1149 Rubinstein M, 2005, J UROLOGY, V174, P442, DOI 10.1097/01.ju.0000165336.44836.2d Thompson GB, 2003, CURR OPIN ONCOL, V15, P84, DOI 10.1097/00001622-200301000-00013 Ulchaker JC, 1999, J UROLOGY, V161, P764, DOI 10.1016/S0022-5347(01)61762-2 NR 14 TC 4 Z9 4 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK STREET, 9TH FLOOR, NEW YORK, NY 10013-1917 USA SN 1743-4270 J9 NAT CLIN PRACT UROL JI Nat. Clin. Pract. Urol. PD NOV PY 2007 VL 4 IS 11 BP 630 EP 633 DI 10.1038/ncpuro0962 PG 4 WC Urology & Nephrology SC Urology & Nephrology GA 226JO UT WOS:000250585500013 PM 17982440 ER PT J AU Soekadar, SR Rilk, A Arfeller, C Laske, C Plewnia, C AF Soekadar, Surjo Raphael Rilk, A. Arfeller, C. Laske, C. Plewnia, C. TI Treatment of incapacitating tinnitus by theta burst stimulation (TBS) SO NERVENARZT LA English DT Meeting Abstract C1 [Soekadar, Surjo Raphael] UKPP, Tubingen, Germany. NR 0 TC 0 Z9 0 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013 USA SN 0028-2804 J9 NERVENARZT JI Nervenarzt PD NOV PY 2007 VL 78 SU 2 BP 117 EP 117 PG 1 WC Clinical Neurology; Psychiatry SC Neurosciences & Neurology; Psychiatry GA 264VP UT WOS:000253318800186 ER PT J AU Kornischka, J Cordes, J Kettenbach, M Agelink, MW AF Kornischka, Jurgen Cordes, J. Kettenbach, M. Agelink, M. W. TI High frequent, repetitive transcranial magnetstimulation (rTMS) for a patient with severe depressive episode and chronic Tinnitus SO NERVENARZT LA German DT Meeting Abstract C1 [Kornischka, Jurgen] Klinikum Herford, Psychiat Klin, Herford, Germany. NR 0 TC 0 Z9 0 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013 USA SN 0028-2804 J9 NERVENARZT JI Nervenarzt PD NOV PY 2007 VL 78 SU 2 BP 262 EP 263 PG 2 WC Clinical Neurology; Psychiatry SC Neurosciences & Neurology; Psychiatry GA 264VP UT WOS:000253318800656 ER PT J AU Langguth, B Landgrebe, M Kleinjung, T Sand, P Eichhammer, P Hajak, G AF Langguth, Berthold Landgrebe, M. Kleinjung, T. Sand, P. Eichhammer, P. Hajak, G. TI Combined temporal and prefrontal rTMS for the treatment of chronic tinnitus SO NERVENARZT LA German DT Meeting Abstract C1 [Langguth, Berthold] Bezirksklinikum Regensburg, Psychiat Klin, Regensburg, Germany. RI Sand, Philipp/C-1924-2009 OI Sand, Philipp/0000-0001-5806-5841 NR 0 TC 0 Z9 0 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013 USA SN 0028-2804 J9 NERVENARZT JI Nervenarzt PD NOV PY 2007 VL 78 SU 2 BP 263 EP 263 PG 1 WC Clinical Neurology; Psychiatry SC Neurosciences & Neurology; Psychiatry GA 264VP UT WOS:000253318800657 ER PT J AU Landgrebe, M Langguth, B Hajak, G Eichhammer, P AF Landgrebe, Michael Langguth, B. Hajak, G. Eichhammer, P. TI Morphological changes for patients with chronic Tinnitus evaluated with voxel-based morphometry SO NERVENARZT LA German DT Meeting Abstract C1 [Landgrebe, Michael] Univ Regensburg, Psychiat Klin, D-8400 Regensburg, Germany. NR 0 TC 0 Z9 0 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013 USA SN 0028-2804 J9 NERVENARZT JI Nervenarzt PD NOV PY 2007 VL 78 SU 2 BP 307 EP 307 PG 1 WC Clinical Neurology; Psychiatry SC Neurosciences & Neurology; Psychiatry GA 264VP UT WOS:000253318800805 ER PT J AU Korte, G Sand, P Kleinjung, T Fischer, B Langguth, B Eichhammer, P Hajak, G AF Korte, Gabriele Sand, P. Kleinjung, T. Fischer, B. Langguth, B. Eichhammer, P. Hajak, G. TI CNTF: a candidates gene for chronic tinnitus? SO NERVENARZT LA German DT Meeting Abstract C1 [Korte, Gabriele] Uniklinikum Regensburg, Psychiat Klin, Regensburg, Germany. RI Sand, Philipp/C-1924-2009 OI Sand, Philipp/0000-0001-5806-5841 NR 0 TC 0 Z9 0 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013 USA SN 0028-2804 J9 NERVENARZT JI Nervenarzt PD NOV PY 2007 VL 78 SU 2 BP 310 EP 310 PG 1 WC Clinical Neurology; Psychiatry SC Neurosciences & Neurology; Psychiatry GA 264VP UT WOS:000253318800816 ER PT J AU D'Amelio, R Schonmetzler, M Bloching, M Delb, W AF D'Amelio, Roberto Schoenmetzler, M. Bloching, M. Delb, W. TI Long term-effects of a disorder specific cognitive behavioural intervention on the psychological stress of patients with sub-acute tinnitus and psychological Secondary symptoms SO NERVENARZT LA German DT Meeting Abstract C1 [D'Amelio, Roberto] Klin Psychol, Psychiat & Psychotherapie, Homburg, Germany. CR DAMELIO R, 2002, TINNITUS MANUAL TINN NR 1 TC 0 Z9 0 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013 USA SN 0028-2804 J9 NERVENARZT JI Nervenarzt PD NOV PY 2007 VL 78 SU 2 BP 326 EP 327 PG 2 WC Clinical Neurology; Psychiatry SC Neurosciences & Neurology; Psychiatry GA 264VP UT WOS:000253318800871 ER PT J AU De Ridder, D Van Laere, K Dupont, P Menovsky, T Van de Heyning, P AF De Ridder, Dirk Van Laere, Koen Dupont, Patrick Menovsky, Tomas Van de Heyning, Pal TI Visualizing out-of-body experience in the brain SO NEW ENGLAND JOURNAL OF MEDICINE LA English DT Article ID SELF-CONSCIOUSNESS; STIMULATION; MECHANISMS; AWARENESS; PET AB An out-of-body experience was repeatedly elicited during stimulation of the posterior part of the superior temporal gyrus on the right side in a patient in whom electrodes had been implanted to suppress tinnitus. Position-emission tomographic scanning showed brain activation at the temporoparietal junction - more specifically, at the angular - supramarginal gyrus junction and the superior temporal gyrus - sulcus on the right side. Activation was also noted at the right precuneus and posterior thalamus, extending into the superior vermis. We suggest that activation of these regions is the neural correlate of the disembodiment that is part of the out-of-body experience. C1 Univ Antwerp, Univ Antwerp Hosp, Dept Neurosurg & Ear Nose & Throat, B-2020 Antwerp, Belgium. Univ Hosp Leuven, Dept Nucl Med, Louvain, Belgium. RP De Ridder, D (reprint author), Univ Antwerp Hosp, Dept Neurosurg, Wilrijkstr 10, B-2650 Edegem, Belgium. 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Engl. J. Med. PD NOV 1 PY 2007 VL 357 IS 18 BP 1829 EP 1833 DI 10.1056/NEJMoa070010 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA 225OJ UT WOS:000250526900006 PM 17978291 ER PT J AU Segal, NT Puterman, M Shkolnik, M Niv, A Kaplan, D Kochva, A Kraus, M AF Segal, Nili Tal Puterman, Max Shkolnik, Mark Niv, Alexander Kaplan, Daniel Kochva, Anat Kraus, Mordechai TI The role of tinnitus evaluation tests in differentiating functional versus organic tinnitus SO OTOLARYNGOLOGY-HEAD AND NECK SURGERY LA English DT Article AB OBJECTIVE: To evaluate the usefulness of tinnitus tests in differentiating patients with functional tinnitus from patients with organic tinnitus. DESIGN: One hundred ninety-six patients with tinnitus were divided into 2 groups. Forty-three patients, group 1, were not exposed to noise and had sensorineural hearing loss. One hundred fifty-three patients, group 2, were exposed to noise and claimed disability. All the patients underwent 4 tinnitus evaluation tests: pitch matching, intensity matching, residual inhibition, and tinnitus masking. We compared the results of the tinnitus tests between the 2 groups. RESULTS: Group I patients had a high-frequency, low-intensity tinnitus that tended to be more inhibited by narrow-band noise, was usually consistent with type I Feldman masking curve, and could be effectively masked. Group 2 patients had tinnitus that could not be characterized. The results of the tinnitus tests were significantly different between the groups. CONCLUSION: Tinnitus tests may help us differentiate functional tinnitus that is not of cochlear origin from genuine tinnitus. (C) 2007 American Academy of Otolaryngology-Head and Neck Surgery Foundation. All rights reserved. C1 Ben Gurion Univ Negev, Dept Otolaryngol Head & Neck Surg, Soroka Univ Med Ctr, IL-84101 Beer Sheva, Israel. Hedim Hearing Inst, Beer Sheva, Israel. RP Segal, NT (reprint author), Ben Gurion Univ Negev, Dept Otolaryngol Head & Neck Surg, Soroka Univ Med Ctr, Box 151, IL-84101 Beer Sheva, Israel. EM avichai@rucc.org.il CR Coles RRA, 1981, CIBA F S, V85, P16 Feldmann H, 1981, J LARYNGOL OTOL S, V4, P60 Schlacher A, 1997, J MOL CATAL B-ENZYM, V3, P25, DOI 10.1016/S1381-1177(96)00034-3 SHEA JJ, 1984, AM J OTOL, V5, P476 SHULMAN A, 1987, AM J OTOL, V8, P479 SHULMAN A, 1984, J LARYNGOL OTOL S, V9, P141 SHULMAN A, 1991, TINNITUS DIAGNOSIS T SHULMAN A, 1987, P 3 INT TINN SEM MUE, P251 SHULMAN A, 1981, J LARYNGOL OTOL S, V4, P1 VERNON J, 1984, J LARYNGOL OTOL, V9, P59 NR 10 TC 1 Z9 2 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0194-5998 J9 OTOLARYNG HEAD NECK JI Otolaryngol. Head Neck Surg. PD NOV PY 2007 VL 137 IS 5 BP 772 EP 775 DI 10.1016/j.otohns.2007.06.717 PG 4 WC Otorhinolaryngology; Surgery SC Otorhinolaryngology; Surgery GA 229RK UT WOS:000250821700015 PM 17967644 ER PT J AU Ashton, H Reid, K Marsh, R Johnson, I Alter, K Griffiths, T AF Ashton, Heather Reid, Keith Marsh, Richard Johnson, Ian Alter, Kai Griffiths, Tim TI High frequency localised "hot spots" in temporal lobes of patients with intractable tinnitus: A quantitative electroencephalographic (QEEG) study SO NEUROSCIENCE LETTERS LA English DT Article DE tinnitus; quantitative EEG (QEEG); temporal lobe high frequency (> 40-80 hz) foci; auditory hallucinations ID MUSICAL HALLUCINATIONS; GAMMA ACTIVITY AB Tinnitus, the perception of noise in the absence of an external auditory stimulus, is common, frequently distressing and often intractable. It is associated with a number of conditions including deafness but may arise spontaneously. Brain imaging studies indicate increased neuronal excitability and decreased density of benzodiazepine receptors in temporal (auditory) cortex but the source and mechanism of such changes are unknown. Various electroencephalographic (EEG) abnormalities involving temporal lobe and other brain areas have been described but recordings have been limited to standard EEG wave bands up to frequencies of 22 Hz. This clinical study of otherwise healthy patients with intractable unilateral tinnitus, using quantitative EEG power spectral mapping (QEEG), identified discrete localised unilateral foci of high frequency activity in the gamma range (>40-80 Hz) over the auditory cortex in eight patients experiencing tinnitus during recording. These high frequency "hot spots" were not present in 25 subjects without tinnitus. The results suggest that further EEG investigations should include recordings in the gamma frequency range since such high frequency oscillations are believed to be necessary for perception. Identification of "hot spots" in tinnitus patients would provide a means for monitoring the effects of new treatments. These findings may also provide a model for exploration of more complex phenomena such as verbal and musical hallucinations. (C) 2007 Elsevier Ireland Ltd. All rights reserved. C1 Univ Newcastle Upon Tyne, Sch Med, Sch Neurol Neurobiol & Psychiat, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England. Freeman Rd Hosp, Dept Otorhinolaryngol Head & Neck Surg, Newcastle Upon Tyne NE7 7DN, Tyne & Wear, England. RP Alter, K (reprint author), Univ Newcastle Upon Tyne, Sch Med, Sch Neurol Neurobiol & Psychiat, Farmlington Pl, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England. EM kai.alter@ncl.ac.uk CR CLEGHORN JM, 1992, AM J PSYCHIAT, V149, P1062 Crone NE, 2001, CLIN NEUROPHYSIOL, V112, P565, DOI 10.1016/S1388-2457(00)00545-9 Crone NE, 2006, PROG BRAIN RES, V159, P275, DOI 10.1016/S0079-6123(06)59019-3 Eggermont JJ, 2004, TRENDS NEUROSCI, V27, P676, DOI 10.1016/j.tins.2004.08.010 FENTON GW, 1989, BRIT J PSYCHIAT, V155, P401 Gray CM, 1999, NEURON, V24, P31, DOI 10.1016/S0896-6273(00)80820-X Kasai K, 1999, LANCET, V354, P1703, DOI 10.1016/S0140-6736(99)05213-7 Llinas R, 2005, TRENDS NEUROSCI, V28, P325, DOI 10.1016/j.tins.2005.04.006 Melcher JR, 2000, J NEUROPHYSIOL, V83, P1058 MILLER TC, 1979, ANN NEUROL, V5, P301, DOI 10.1002/ana.410050314 Shulman Abraham, 2002, Int Tinnitus J, V8, P77 Shulman Abraham, 2002, Int Tinnitus J, V8, P30 Shulman Abraham, 2005, Int Tinnitus J, V11, P1 Shulman Abraham, 2006, Int Tinnitus J, V12, P121 Singer W, 1999, NEURON, V24, P49, DOI 10.1016/S0896-6273(00)80821-1 SOONG ACK, 1993, ELECTROEN CLIN NEURO, V87, P185, DOI 10.1016/0013-4694(93)90018-Q Daftary Aditya, 2004, Int Tinnitus J, V10, P17 Tallon-Baudry C, 1999, TRENDS COGN SCI, V3, P151, DOI 10.1016/S1364-6613(99)01299-1 Weiler Elmar W J, 2004, Int Tinnitus J, V10, P127 WEILER EW, 2006, INT TINNITUS J, V6, P24 Weiss AP, 1999, PSYCHIAT RES-NEUROIM, V92, P61, DOI 10.1016/S0925-4927(99)00041-4 WEISZ N, 2007, J NEUROSCI, V7, P1479 Yamada T, 2003, NEUROSCI LETT, V337, P21, DOI 10.1016/S0304-3940(02)01294-6 NR 23 TC 26 Z9 28 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0304-3940 J9 NEUROSCI LETT JI Neurosci. Lett. PD OCT 9 PY 2007 VL 426 IS 1 BP 23 EP 28 DI 10.1016/j.neutet.2007.08.034 PG 6 WC Neurosciences SC Neurosciences & Neurology GA 224VU UT WOS:000250476000005 PM 17888572 ER PT J AU Di Nardo, W Cantore, I Cianfrone, F Melillo, P Scorpecci, A Paludetti, G AF Di Nardo, Walter Cantore, Italo Cianfrone, Francesca Melillo, Pietro Scorpecci, Alessandro Paludetti, Gaetano TI Tinnitus modifications after cochlear implantation SO EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY LA English DT Article DE tinnitus; cochlear implant ID SUPPRESSION AB Tinnitus can be defined as a phantom sensation in the absence of an external sound. In our study, we evaluated the effect of cochlear implant on tinnitus evolution. Among adult, postlingually deaf patients who underwent cochlear implantation at our clinic, we selected 20 subjects with pre-implantation tinnitus (group A) and 10 subjects without pre-implantation tinnitus (group B). Pre- and post-surgery tinnitus was assessed through two questionnaires: the first one dealing with tinnitus characteristics and psychosocial impact, and the second one represented by THI, an internationally validated score of evaluation of the effects of tinnitus on patient's emotions and activities of daily living. None of the patients belonging to group B developed tinnitus after surgery. As for group A, 40% of patients declared suppression of tinnitus, 30% attenuation of tinnitus after surgery, 25% reported tinnitus was unchanged and 5% reported worsening of tinnitus. In the nine patients with bilateral tinnitus (45%), after implantation tinnitus disappeared from both sides in four patients and attenuated bilaterally in four patients. A comparison between pre- and post-implantation THI scores showed decreased score in 65% of cases, unchanged score in 30% and increased score in 5%. The beneficial effect of cochlear implant on tinnitus, reported by a majority of patients, could be due to acoustic masking, to direct electrical stimulation of the acoustic nerve, and above all to a possible cochlear implantation dependent reorganization of the central auditory pathways and associative cerebral areas. In the light of these results, the authors propose (1) to include tinnitus in the selection criteria of which ear to implant; (2) to consider implantation eligibility for patients with bilateral severe hearing loss associated with severe tinnitus; and (3) to inform patients about the small risk of post-operative tinnitus worsening. C1 Univ Cattolica Sacro Cuore, Inst Otorhinolaryngol, A Gemelli Univ Hosp, I-00168 Rome, Italy. RP Di Nardo, W (reprint author), Univ Cattolica Sacro Cuore, Inst Otorhinolaryngol, A Gemelli Univ Hosp, Largo Gemelli 8, I-00168 Rome, Italy. EM dinardow@libero.it CR Aschendorff A., 1998, INT TINNITUS J, V4, P162 BATTMER RD, 1989, HNO, V37, P148 CIANFRONE G, 2004, AUDIOL NEWSL, V8, P3 Demajumdar R, 1999, J Laryngol Otol Suppl, V24, P24 Eggermont JJ, 2004, TRENDS NEUROSCI, V27, P676, DOI 10.1016/j.tins.2004.08.010 FUKUDA Y, 1998, INT TINNITUS J, V4, P159 Giraud AL, 2001, BRAIN, V124, P1307, DOI 10.1093/brain/124.7.1307 JASTREBOFF PJ, 1990, NEUROSCI RES, V8, P221, DOI 10.1016/0168-0102(90)90031-9 Mo B, 2002, INT J AUDIOL, V41, P527, DOI 10.3109/14992020209056073 Newman CW, 1996, ARCH OTOLARYNGOL, V122, P143 OTTAVIANI A, 1983, ATT 70 C NAZ SOC IT, P25 Quaranta N, 2004, INT J AUDIOL, V43, P245, DOI 10.1080/14992020400050033 RUBERNSTEIN M, 2003, OTOL NEUROTOL, V22, P200 SOULIERE CR, 1992, ARCH OTOLARYNGOL, V118, P1291 YASUHIRO O, 2005, NEUROREPORT, V16, P1625 NR 15 TC 16 Z9 16 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013 USA SN 0937-4477 J9 EUR ARCH OTO-RHINO-L JI Eur. Arch. Oto-Rhino-Laryn. PD OCT PY 2007 VL 264 IS 10 BP 1145 EP 1149 DI 10.1007/s00405-007-0352-7 PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA 208DS UT WOS:000249300600005 PM 17558507 ER PT J AU Noble, W Tyler, R AF Noble, William Tyler, Richard TI Physiology and phenomenology of tinnitus: Implications for treatment SO INTERNATIONAL JOURNAL OF AUDIOLOGY LA English DT Article DE tinnitus; physiology; phenomenology; treatment; handicap; psychology; audiology ID HEARING-LOSS; DISTRESS; IMPAIRMENT; SUFFERERS; SYSTEM; SOUND; LINKS AB We examine a contrast in understanding tinnitus and how this impacts on treatment approaches. First, a physiological account of tinnitus is described based on disinhibition and cortical remapping following injury at the receptor level, the analog for tinnitus being the 'phantom limb pain' phenomenon. Secondly, an experimental model of tinnitus is reviewed that relies on inference from conditioning animal behaviour. Arising from this, a role for conditioning in people distressed by tinnitus has been proposed, based on the unfounded premise that, for humans, tinnitus is a neutral stimulus, the distress being due to association with other stressful events. We critique this because we believe it influences approaches to tinnitus treatment. Finally, the phenomenology of tinnitus in the human case is analysed, with its nature illuminated via a series of distinctions with hearing impairment. Tinnitus can be intrinsically stressful for some people. Understanding this emphasizes the need to involve concepts and treatment in the area of clinical psychology. A flexible coalition between clinical audiologists and clinical psychologists is proposed as fruitful for tinnitus and related rehabilitation. C1 Univ New England, Sch Psychol, Armidale, NSW 2351, Australia. Univ Iowa, Dept Otolaryngol, Iowa City, IA USA. RP Noble, W (reprint author), Univ New England, Sch Psychol, Armidale, NSW 2351, Australia. CR Anderson DL, 2005, INT J AUDIOL, V44, P197, DOI 10.1080/14992020500057699 Andersson G, 1999, BRIT J AUDIOL, V33, P201 Andersson Gerhard, 2000, Scandinavian Journal of Behaviour Therapy, V29, P57 ATHERLEY GR, 1968, J ACOUST SOC AM, V44, P1503, DOI 10.1121/1.1911288 Burkard R., 2000, TINNITUS HDB Cacace AT, 2003, HEARING RES, V175, P112, DOI 10.1016/S0378-5955(02)00717-7 Chalfant AM, 2004, J TRAUMA STRESS, V17, P423, DOI 10.1023/B:JOTS.0000048955.65891.4c Cole MG, 2002, INT J GERIATR PSYCH, V17, P444, DOI 10.1002/gps.618 DAVIS H, 1950, Acta Otolaryngol Suppl, V88, P1 DEVESA PM, 2007, COCHRANE DATABASE SY ERIKSSONMANGOLD M, 1991, J PSYCHOSOM RES, V35, P729, DOI 10.1016/0022-3999(91)90124-7 ERLANDSSON SI, 1992, AUDIOLOGY, V31, P168 FLOR H, 1995, NATURE, V375, P482, DOI 10.1038/375482a0 Gatehouse S, 2004, INT J AUDIOL, V43, P85, DOI 10.1080/14992020400050014 GOEBEL G, 1999, 6 INT TINN SEM CAMBR HALFORD JBS, 1991, J PSYCHOSOM RES, V35, P383, DOI 10.1016/0022-3999(91)90033-K HALL T S, 1970, Journal of the History of Biology, V3, P53, DOI 10.1007/BF00569306 HALLAM RS, 2005, TINNITUS TREATMENT C, P65 Heffner HE, 2005, BEHAV NEUROSCI, V119, P734, DOI 10.1037/0735-7044.119.3.734 Henry J. 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F., 1969, CONTINGENCIES REINFO Surr R K, 1999, J Am Acad Audiol, V10, P489 SURR RK, 1985, EAR HEARING, V6, P71, DOI 10.1097/00003446-198503000-00002 Tyler R. S., 2006, TINNITUS TREATMENT C, P1 TYLER R S, 1987, Seminars in Hearing, V8, P49, DOI 10.1055/s-0028-1089904 TYLER RS, IN PRESS HDB CLIN AU Weisz N, 2004, BMC NEUROSCI, V5, DOI 10.1186/1471-2202-5-8 NR 51 TC 10 Z9 10 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 1499-2027 J9 INT J AUDIOL JI Int. J. Audiol. PD OCT PY 2007 VL 46 IS 10 BP 569 EP 574 DI 10.1080/14992020701506296 PG 6 WC Audiology & Speech-Language Pathology; Otorhinolaryngology SC Audiology & Speech-Language Pathology; Otorhinolaryngology GA 232CO UT WOS:000250996000003 PM 17922346 ER PT J AU Truong, MT Winzelberg, J Chang, KW AF Truong, Mai Thy Winzelberg, Jody Chang, Kay W. TI Recovery from cisplatin-induced ototoxicity: A case report and review SO INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY LA English DT Article DE cisplatin; ototoxicity; pediatric; recovery ID HIGH-DOSE CISPLATIN; ALBINO GUINEA-PIG; STRIA VASCULARIS; HEARING-LOSS; OTOACOUSTIC EMISSIONS; CLINICAL-EXPERIENCE; CIS-PLATINUM; CHILDREN; CHEMOTHERAPY; TOXICITY AB We present a pediatric case report of cisptatin-induced ototoxicity with subsequent recovery. The patient experienced tinnitus and fluctuating mild high-frequency sensorineural hearing toss (SNHL) with a concomitant decrease in distortion product otoacoustic emissions (DPOAE). There was recovery of hearing toss and return of DPOAE at 1 year after completion of cisplatin therapy. Reports of recovery from cispLatin-induced ototoxicity in humans are limited in the literature, especially in the pediatric population. A review of cisplatin ototoxicity and mechanisms of recovery are discussed, with an emphasis on the particular chemotherapy regimen and dosing schedule in this case, given at 4-11 week intervals. (c) 2007 Elsevier Ireland Ltd. All rights reserved. C1 Lucile Packard Childrens Hosp, Palo Alto, CA 94304 USA. Stanford Hosp & Clin, Stanford, CA 94305 USA. RP Chang, KW (reprint author), Lucile Packard Childrens Hosp, Palo Alto, CA 94304 USA. 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J. Pediatr. Otorhinolaryngol. PD OCT PY 2007 VL 71 IS 10 BP 1631 EP 1638 DI 10.1016/j.ijporl.2007.06.021 PG 8 WC Otorhinolaryngology; Pediatrics SC Otorhinolaryngology; Pediatrics GA 216VK UT WOS:000249906900021 PM 17706797 ER PT J AU Griffitts, TM Collins, CP Collins, PC Beirne, OR AF Griffitts, Trevor M. Collins, Chad P. Collins, Patrick C. Beirne, O. Ross TI Walker repair of the temporomandibular joint: A retrospective evaluation of 117 patients SO JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY LA English DT Article ID INTERNAL DERANGEMENTS; SURGERY; DISK; RECONSTRUCTION; ARTHROPLASTY; MANAGEMENT; MENISCUS AB Purpose: This study evaluated the outcome of a high condylar shave with meniscal repositioning (Walker repair) in patients with internal derangement of the temporomandibular joint (TMJ). Changes in incisal opening, pain level, chewing ability, and preoperative TMJ symptoms (tinnitus, vertigo, and crepitus) were evaluated. Patients and Methods: A retrospective evaluation of 202 patients undergoing the Walker repair was completed using a questionnaire. A total of 117 patients responded to the questionnaire. Preoperative and postoperative examination findings, subjective questionnaire results, and panorex radiographs were analyzed. Results: The Walker repair resulted in a statistically significant (P < .001) decrease in pain by an average of 5.6 points on a scale of 0 to 10. The procedure also improved incisal opening by an average of 5.8 mm (P < .001). Improvements of 69% in tinnitus, 72% in vertigo, and 66% in crepitus were documented. Patients evaluated their motion, diet, comfort, and overall improvement; each area was rated as good or excellent by more than 90% of patients. The overall success rate for the Walker repair was 86%. Conclusions: The Walker repair is an effective surgical treatment for internal derangement that significantly decreases pain level and increases incisal opening. No statistically significant difference in the success rate between unilateral and bilateral procedures was noted. (c) 2007 American Association of Oral and Maxillofacial Surgeons. C1 Collins Oral Surg, Spokane, WA 99204 USA. Temple Univ, Sch Dent, Philadelphia, PA USA. Univ Washington, Sch Dent, Dept Oral & Maxillofacial Surg, Seattle, WA 98195 USA. RP Griffitts, TM (reprint author), Collins Oral Surg, 322 W 7th Ave, Spokane, WA 99204 USA. 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PD OCT PY 2007 VL 65 IS 10 BP 1958 EP 1962 DI 10.1016/j.joms.2007.05.012 PG 5 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA 217HM UT WOS:000249939000009 PM 17884522 ER PT J AU Montoya, FS Ibarguen, AM del Rey, AS Fernandez, JMS AF Montoya, Francisco Santaolalla Ibarguen, Agustin Martinez del Rey, Ana Sanchez Fernandez, Jose Maria Sanchez TI Evaluation of cochlear function in patients with tinnitus using spontaneous and transitory evoked otoacoustic emissions SO JOURNAL OF OTOLARYNGOLOGY LA English DT Article DE spontaneous otoacoustic emissions; tinnitus; transitory evoked otoacoustic emissions ID CLINICAL-APPLICATIONS; AUDITORY-SYSTEM; HEARING-LOSS; HUMAN EARS; MECHANISMS; ORIGIN AB Objective: The aim of this paper has been to investigate the cochlear function and the basic properties of otoacoustic emissions (OAEs) in patients with tinnitus using Spontaneous Otoacoustic Emissions (SOAEs) and Transitory Evoked Otoacoustic Emissions (TEOAEs). Materials and Methods: We have analyzed the incidence, amplitude and spectral content of hearing thresholds, SOAEs and TEOAEs in a sample of 44 ears. We have measured incidence, intensity, frequency, number of peaks and amplitude of emission and their variability across frequency range from 500 to 5000 Hz. A correlation was determined between the OAEs results and the results obtained using hearing thresholds. Results: We have not found statistically significant differences at 500, 1000, 2000, 4000 and 8000 Hz frequencies neither at mean hearing thresholds between the sample of ears with tinnitus and the sample of ears without tinnitus. SOAEs were only present in 1 of the 44 ears tested (2.27%) and it was a 17 dB SPL amplitude peak at 2770 Hz frequency. TEOAEs, however, were displayed in some frequency in all the ears. We have compared TEOAEs parameters between the sample of ears with tinnitus and the sample of ears without tinnitus in 500, 1000, 2000, 4000 and 5000 Hz frequencies, and we have only found statistically significant differences at 4000 Hz, p=0.02. Comparison of TEOAEs parameters between ears with tinnitus and ears without tinnitus in the same patient have only found statistically significant differences at 4000 Hz frequency, p=0.011. In both cases there were not statistically significant differences at 500, 1000, 2000 and 5000 Hz frequencies nor at mean TEOAEs amplitudes for every group. Conclusions: We have not found significant relations between tinnitus and OAEs registration. C1 Univ Basque Country, Basurto Hosp, Sch Med, Dept Otorhinolaryngol, Bilbao, Spain. RP Montoya, FS (reprint author), Univ Basque Country, Basurto Hosp, Sch Med, Dept Ear Nose & Throat, Gurtubay, S-N, E-48013 Bilbao, Spain. EM francisco.santaolalla@ehu.es CR ABDO MH, 1993, INT J PEDIATR OTORHI, V25, P61, DOI 10.1016/0165-5876(93)90010-Z Attias J, 1996, ACTA OTO-LARYNGOL, V116, P534, DOI 10.3109/00016489609137885 BONFILS P, 1989, LARYNGOSCOPE, V99, P752 Cacace AT, 2003, HEARING RES, V175, P112, DOI 10.1016/S0378-5955(02)00717-7 CHERYCROZE S, 1993, ACTA OTO-LARYNGOL, V113, P285, DOI 10.3109/00016489309135810 Folmer RL, 2000, AM J OTOLARYNG, V21, P287, DOI 10.1053/ajot.2000.9871 HAZELL JWP, 1990, J OTOLARYNGOL, V19, P1 HELLER MF, 1953, ANN OTO RHINOL LARYN, V62, P73 JASTREBOFF PJ, 1990, NEUROSCI RES, V8, P221, DOI 10.1016/0168-0102(90)90031-9 Kaltenbach JA, 2005, HEARING RES, V206, P200, DOI 10.1016/j.heares.2005.02.013 KEMP DT, 1978, J ACOUST SOC AM, V64, P1386, DOI 10.1121/1.382104 Lockwood AH, 2002, NEW ENGL J MED, V347, P904, DOI 10.1056/NEJMra013395 LONSBURYMARTIN BL, 1991, J SPEECH HEAR RES, V34, P964 MARTIN GK, 1990, EAR HEARING, V11, P106 NORTON SJ, 1990, EAR HEARING, V11, P159, DOI 10.1097/00003446-199004000-00011 PENNER M J, 1992, British Journal of Audiology, V26, P91, DOI 10.3109/03005369209077876 PENNER MJ, 1987, J SPEECH HEAR RES, V30, P396 PENNER MJ, 1994, OTOLARYNG HEAD NECK, V110, P304, DOI 10.1016/S0194-5998(94)70774-X PLINKERT PK, 1990, ACTA OTO-LARYNGOL, V110, P342, DOI 10.3109/00016489009107453 PROBST R, 1987, AM J OTOLARYNG, V8, P73, DOI 10.1016/S0196-0709(87)80027-3 Rosanowski F, 1997, HNO, V45, P927, DOI 10.1007/s001060050176 TANAKA Y, 1987, ACTA OTO-LARYNGOL, V103, P644 TONNDORF J, 1980, ANN OTO RHINOL LARYN, V89, P353 WILSON JP, 1980, HEARING RES, V2, P233, DOI 10.1016/0378-5955(80)90060-X ZUREK PM, 1981, J ACOUST SOC AM, V69, P514, DOI 10.1121/1.385481 NR 25 TC 6 Z9 7 PU B C DECKER INC PI HAMILTON PA 50 KING STREET EAST, 2ND FLOOR, PO BOX 620, L C D 1, HAMILTON, ONTARIO L8N 3K7, CANADA SN 0381-6605 J9 J OTOLARYNGOL JI J. Otolaryngol. PD OCT PY 2007 VL 36 IS 5 BP 296 EP 302 DI 10.2310/7070.2007.0046 PG 7 WC Otorhinolaryngology SC Otorhinolaryngology GA 233WY UT WOS:000251122200007 ER PT J AU Hesse, PDG AF Hesse, P. D. Gerhard TI Tinnitus - Is the modern Hypnosis according to Erickson a therapy option? Commentary SO LARYNGO-RHINO-OTOLOGIE LA German DT Editorial Material C1 Tinnitus Klin Bad Arolsen, D-34454 Bad Arolsen, Germany. RP Hesse, PDG (reprint author), Tinnitus Klin Bad Arolsen, Grosse Allee 1-3, D-34454 Bad Arolsen, Germany. NR 0 TC 0 Z9 0 PU GEORG THIEME VERLAG KG PI STUTTGART PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY SN 0935-8943 J9 LARYNGO RHINO OTOL JI Laryngo-Rhino-Otol. PD OCT PY 2007 VL 86 IS 10 BP 694 EP 695 PG 2 WC Otorhinolaryngology SC Otorhinolaryngology GA 220FW UT WOS:000250143600005 ER PT J AU Singer, W AF Singer, Wibke TI Tinnitus - Is the modern Hypnosis according to Erickson a therapy option? SO LARYNGO-RHINO-OTOLOGIE LA German DT Editorial Material NR 0 TC 0 Z9 0 PU GEORG THIEME VERLAG KG PI STUTTGART PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY SN 0935-8943 J9 LARYNGO RHINO OTOL JI Laryngo-Rhino-Otol. PD OCT PY 2007 VL 86 IS 10 BP 694 EP 694 PG 1 WC Otorhinolaryngology SC Otorhinolaryngology GA 220FW UT WOS:000250143600004 ER PT J AU Sittel, C AF Sittel, Christian TI Tinnitus - Is the modern Hypnosis according to Erickson a therapy option? Commentary SO LARYNGO-RHINO-OTOLOGIE LA German DT Editorial Material C1 Univ HNO Klin, D-69120 Heidelberg, Germany. RP Sittel, C (reprint author), Univ HNO Klin, Im Neuenheimer Feld 400, D-69120 Heidelberg, Germany. NR 0 TC 0 Z9 0 PU GEORG THIEME VERLAG KG PI STUTTGART PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY SN 0935-8943 J9 LARYNGO RHINO OTOL JI Laryngo-Rhino-Otol. PD OCT PY 2007 VL 86 IS 10 BP 695 EP 695 PG 1 WC Otorhinolaryngology SC Otorhinolaryngology GA 220FW UT WOS:000250143600006 ER PT J AU Langguth, B Stadtlaender, H Landgrebe, M Elgoyhen, AB Coors, H Vielsmeier, V Kleinjung, T AF Langguth, Berthold Stadtlaender, Hans Landgrebe, Michael Elgoyhen, Ana Belen Coors, Hermann Vielsmeier, Veronika Kleinjung, Tobias TI Tinnitus and Coxsackie B infections: A case series SO NEUROENDOCRINOLOGY LETTERS LA English DT Article DE tinnitus; enterovirus infections; hearing loss; Coxsackie B; meningoencephalitis ID SUDDEN HEARING-LOSS; ENTEROVIRUS INFECTIONS; PLECONARIL AB Tinnitus is a frequent and often debilitating condition. There is consensus in the scientific community that there exist various forms of tinnitus, which differ in their pathogenesis. Here we report a series of five cases where the onset of tinnitus was associated with viral infections. In all five patients elevated antibodies against Coxsackie B have been detected. This observation suggests that Coxsackie B Virus infections might be involved in the development of some cases of tinnitus and indicate that further systematic investigations are warranted. C1 [Langguth, Berthold; Landgrebe, Michael] Univ Regensburg, Dept Psychiat, D-8400 Regensburg, Germany. [Elgoyhen, Ana Belen] Inst Invest Ingn Genet & Biol Mol, Buenos Aires, DF, Argentina. [Vielsmeier, Veronika; Kleinjung, Tobias] Univ Regensburg, Dept Otorhinolaryngol, D-8400 Regensburg, Germany. RP Langguth, B (reprint author), Univ Regensburg, Dept Psychiat & Psychotherapy, Univ Str 84, D-93053 Regensburg, Germany. EM berthold.langguth@medbo.de CR Adour K.K., 1994, ANN NEUROL, V35, P62 Coles R R, 1984, J Laryngol Otol Suppl, V9, P7 GARCIABERROCAL JRG, 2000, ACTA OTO-LARYNGOL, V120, P835 Mentel R, 2004, J MED VIROL, V72, P625, DOI 10.1002/jmv.20014 Moller AR, 2003, OTOLARYNG CLIN N AM, V36, P249, DOI 10.1016/S003-6665(02)00170-6 Romero JR, 2001, EXPERT OPIN INV DRUG, V10, P369, DOI 10.1517/13543784.10.2.369 Rotbart HA, 2001, CLIN INFECT DIS, V32, P228, DOI 10.1086/318452 Schattner A, 2003, CAN MED ASSOC J, V168, P1421 SHIAN WJ, 1994, PEDIATR INFECT DIS J, V13, P756, DOI 10.1097/00006454-199408000-00022 Sweeney CJ, 2001, J NEUROL NEUROSUR PS, V71, P149, DOI 10.1136/jnnp.71.2.149 Venail F, 2007, GENE THER, V14, P30, DOI 10.1038/sj.gt.3302826 Yoshida Yasuyuki, 1996, Auris Nasus Larynx, V23, P63 NR 12 TC 1 Z9 1 PU MAGHIRA & MAAS PUBLICATIONS PI STOCKHOLM PA PO BOX 26132, S-100 41 STOCKHOLM, SWEDEN SN 0172-780X J9 NEUROENDOCRINOL LETT JI Neuroendocrinol. Lett. PD OCT PY 2007 VL 28 IS 5 BP 554 EP 555 PG 2 WC Endocrinology & Metabolism; Neurosciences SC Endocrinology & Metabolism; Neurosciences & Neurology GA 246CX UT WOS:000251986200009 PM 17984924 ER PT J AU Luo, CW Liu, CJ Chang, KM AF Luo, Chin-Wan Liu, Chung-Ji Chang, Kuo-Ming TI Synovial sarcoma of the temporomandibular joint area: report of a case SO ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTOLOGY LA English DT Article ID CELL-SARCOMA; HEAD; NECK AB Synovial cell sarcoma is a relatively rare tumor of mesenchymal origin. It is a high-grade neoplasm that microscopically shows a monophasic or biphasic cellular pattern and includes epithelial features as well as supporting tissue features. Surgical excision is the primary mode of treatment. Postoperative radiotherapy and chemotherapy also is seen to be helpful. Between 3% and 10% of cases originate in the head and neck. A review of relevant literature shows less than 10 cases of synovial cell sarcoma of the temporomandibular joint area reported in the English literature. We report an additional case of biphasic synovial cell sarcoma arising in the temporomandibular joint area, which caused ear pain, tinnitus, and hearing loss, and we further discuss the clinical features, histopathology, differential diagnosis, and treatment modality. C1 Mackay Mem Hosp, Dept Oral & Maxillofacial Surg, Taipei 10449, Taiwan. Taipei Med Univ Hosp, Dept Dent, Div Oral & Maxillofacial Surg, Taipei, Taiwan. Natl Yang Ming Univ, Sch Dent, Taipei, Taiwan. Mackay Mem Hosp, Dept Pathol, Taipei, Taiwan. Natl Taiwan Univ Hosp, Dept Pathol, Taipei 100, Taiwan. RP Liu, CJ (reprint author), Mackay Mem Hosp, Dept Oral & Maxillofacial Surg, No 92,Chung-Shan N Rd,Sec 2, Taipei 10449, Taiwan. EM cjliu@ms2.mmh.org.tw CR AMBLE FR, 1992, OTOLARYNG HEAD NECK, V107, P631 BRIDGE JA, 1988, CANCER, V62, P935, DOI 10.1002/1097-0142(19880901)62:5<935::AID-CNCR2820620514>3.0.CO;2-E BUKACHEVSKY RP, 1992, HEAD NECK-J SCI SPEC, V14, P44, DOI 10.1002/hed.2880140110 CARRILLO R, 1992, ANN OTO RHINOL LARYN, V101, P367 Cihak RA, 1997, HEAD NECK-J SCI SPEC, V19, P549 Koyama S, 2001, PATHOL INT, V51, P385, DOI 10.1046/j.1440-1827.2001.01203.x Mostafapour SP, 2000, OTOLARYNG HEAD NECK, V123, P459, DOI 10.1067/mhn.2000.109662 MULLEN JR, 1994, RADIOTHER ONCOL, V33, P23, DOI 10.1016/0167-8140(94)90082-5 Rangheard AS, 2001, AM J NEURORADIOL, V22, P851 SHMOOKLER BM, 1982, CANCER, V50, P269, DOI 10.1002/1097-0142(19820715)50:2<269::AID-CNCR2820500217>3.0.CO;2-7 Stadelmann WK, 1995, ANN PLAS SURG, V35, P664, DOI 10.1097/00000637-199512000-00020 WHITE RD, 1992, J ORAL MAXIL SURG, V50, P1227, DOI 10.1016/0278-2391(92)90160-2 NR 12 TC 7 Z9 7 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 1079-2104 J9 ORAL SURG ORAL MED O JI Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod. PD OCT PY 2007 VL 104 IS 4 BP E62 EP E65 DI 10.1016/j.tripleo.2007.05.009 PG 4 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA 220QA UT WOS:000250170300037 PM 17703967 ER PT J AU Kleinjung, T Steffens, T Sand, P Murthum, T Hajak, G Strutz, J Langguth, B Eichhammer, P AF Kleinjung, Tobias Steffens, Thomas Sand, Philipp Murthum, Tobias Hajak, Goeran Strutz, Juergen Langguth, Berthold Eichhammer, Peter TI Which tinnitus patients benefit from transcranial magnetic stimulation? SO OTOLARYNGOLOGY-HEAD AND NECK SURGERY LA English DT Article; Proceedings Paper CT 110th Annual Meeting of the American-Academy-of-Otolaryngology-Head-and-Neck-Surgery-Foundation CY SEP 17-20, 2006 CL Toronto, CANADA SP Amer Acad Otolaryngol Head & Neck Surg Fdn ID AUDITORY-CORTEX; BRAIN; SUPPRESSION AB OBJECTIVES: Chronic tinnitus is associated with hyperactivity of the central auditory system. Low-frequency repetitive transcranial magnetic stimulation (rTMS) of the temporal cortex has been proposed as a treatment for chronic tinnitus. This study determined the factors that predict a beneficial outcome with rTMS treatment. STUDY DESIGN: Forty-five patients with chronic tinnitus underwent 10 sessions of low-frequency rTMS to their left auditory cortex. The treatment outcome was assessed with a tinnitus questionnaire. Therapeutic success was related to the patients' clinical characteristics. RESULTS: A significant reduction in tinnitus complaints occurred after rTMS. In the questionnaire, 40% of the patients improved by five points or more. Treatment responders were characterized by shorter duration of tinnitus complaints and no hearing impairment. CONCLUSION: Tinnitus-related neuroplastic changes might be less pronounced in patients with normal hearing and a short history of complaints. This could explain why those patients benefitted more from rTMS treatment. (c) 2007 American Academy of Otolaryngology-Head and Neck Surgery Foundation. All rights reserved. C1 Univ Regensburg, Dept Otorhinolaryngol, D-93053 Regensburg, Germany. Univ Regensburg, Dept Psychiat, D-8400 Regensburg, Germany. Univ Regensburg, Dept Psychotherapy, D-8400 Regensburg, Germany. RP Kleinjung, T (reprint author), Univ Regensburg, Dept Otorhinolaryngol, Franz Josef Str Allee 1, D-93053 Regensburg, Germany. EM tobias.kleinjung@klinik.uni-regensburg.de RI Sand, Philipp/C-1924-2009 OI Sand, Philipp/0000-0001-5806-5841 CR Arnold W, 1996, ORL J OTO-RHINO-LARY, V58, P195 Coles R R, 1984, J Laryngol Otol Suppl, V9, P7 De Ridder D, 2005, OTOL NEUROTOL, V26, P616, DOI 10.1097/01.mao.0000178146.91139.3c De Ridder D, 2006, ORL J OTO-RHINO-LARY, V68, P48, DOI 10.1159/000090491 Dobie RA, 1999, LARYNGOSCOPE, V109, P1202, DOI 10.1097/00005537-199908000-00004 Eggermont JJ, 2005, DRUG DISCOV TODAY, V10, P1283, DOI 10.1016/S1359-6446(05)03542-7 Eichhammer P, 2003, BIOL PSYCHIAT, V54, P862, DOI 10.1016/S0006-3223(03)01896-6 GOEBEL G, 1998, HANDAWEISUNG, P1 Hallett M, 2000, NATURE, V406, P147, DOI 10.1038/35018000 Hoffman RE, 2002, AM J PSYCHIAT, V159, P1093, DOI 10.1176/appi.ajp.159.7.1093 JASTREBOFF PJ, 1990, NEUROSCI RES, V8, P221, DOI 10.1016/0168-0102(90)90031-9 Kaltenbach J A, 2000, J Am Acad Audiol, V11, P125 Kleinjung T, 2005, OTOLARYNG HEAD NECK, V132, P566, DOI 10.1016/j.otohns.2004.09.134 LANGGUTH B, 2006, ACTA OTO-LARYNGOL, V556, P84, DOI DOI 10.1080/03655230600895317 Langguth B, 2006, BRAIN TOPOGR, V18, P241, DOI 10.1007/s10548-006-0002-1 May A, 2007, CEREB CORTEX, V17, P205, DOI 10.1093/cercor/bhj138 Moller AR, 2003, OTOLARYNG CLIN N AM, V36, P249, DOI 10.1016/S003-6665(02)00170-6 Muhlau M, 2006, CEREB CORTEX, V16, P1283, DOI 10.1093/cercor/bhj070 Plewnia C, 2003, ANN NEUROL, V53, P263, DOI 10.1002/ana.10468 Plewnia C, 2007, HUM BRAIN MAPP, V28, P238, DOI 10.1002/hbm.20270 NR 20 TC 64 Z9 66 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 0194-5998 J9 OTOLARYNG HEAD NECK JI Otolaryngol. Head Neck Surg. PD OCT PY 2007 VL 137 IS 4 BP 589 EP 595 DI 10.1016/j.otohns.2006.12.007 PG 7 WC Otorhinolaryngology; Surgery SC Otorhinolaryngology; Surgery GA 218MO UT WOS:000250019800012 PM 17903575 ER PT J AU Jagannathan, J Lonser, RR Stanger, RA Butman, JA Vortmeyer, AO Zalewski, CK Brewer, C Surowicz, C Kim, HJ AF Jagannathan, Jay Lonser, Russell R. Stanger, Richard A. Butman, John A. Vortmeyer, Alexander O. Zalewski, Christopher K. Brewer, Carmen Surowicz, Christal Kim, H. Jeffrey TI Cochlear implantation for hearing loss associated with bilateral endolymphatic sac tumors in von Hippel-Lindau disease SO OTOLOGY & NEUROTOLOGY LA English DT Article DE bilateral; cochlear implant; endolymphatic sac tumor; hearing loss; von Hippel-Lindau disease ID LOW-GRADE ADENOCARCINOMA; NEUROFIBROMATOSIS TYPE-2; SURGERY; ORIGIN AB Objective: Bilateral endolymphatic sac tumors (ELSTs) are associated with von Hippel-Lindau disease and often underlie significant audiovestibular morbidity, including hearing loss. Patient: This 44-year-old female von Hippel-Lindau disease patient presented with tinnitus, vertigo, and binaural hearing loss. Magnetic resonance and computed tomography imaging demonstrated bilateral ELSTs, and audiometry confirmed bilateral hearing loss. Intervention: The patient underwent staged resection of the ELSTs (left then right). After resection of the left ELST and during the same operation, a cochlear implant was placed. Main Outcome Measures: Clinical, audiometric, and imaging data. Results: Postoperatively, the patient had resolution of tinnitus and vertigo with a significant implant-aided improvement in hearing. Conclusion: Because of their unique anatomic and biologic features, resection of bilateral tumors and cochlear implantation in deaf ELST patients is a potential option to improve hearing and quality of life. C1 NINDS, Surg Neurol Branch, NIH, Bethesda, MD 20892 USA. Univ Virginia, Hlth Sci Ctr, Dept Neurosurg, Charlottesville, VA 22908 USA. Natl Inst Deafness & Other Commun Disorders, Dept Diagnost Radiol, Warren G Magnuson Clin Ctr, NIH, Bethesda, MD USA. Natl Inst Deafness & Other Commun Disorders, Otolaryngol Branch, NIH, Bethesda, MD USA. Washington Hosp Ctr, Hearing & Speech Ctr, Washington, DC 20010 USA. Georgetown Univ, Med Ctr, Dept Otolaryngol Head & Neck Surg, Washington, DC 20007 USA. RP Lonser, RR (reprint author), NINDS, Surg Neurol Branch, NIH, Bldg 10,Room 5D37, Bethesda, MD 20892 USA. EM lonserr@ninds.nih.gov RI Butman, John/A-2694-2008 CR Belal A, 2001, OTOL NEUROTOL, V22, P497, DOI 10.1097/00129492-200107000-00015 Hansen MR, 2004, LARYNGOSCOPE, V114, P1470, DOI 10.1097/00005537-200408000-00028 HEFFNER DK, 1989, CANCER, V64, P2292, DOI 10.1002/1097-0142(19891201)64:11<2292::AID-CNCR2820641119>3.0.CO;2-# Kim HJ, 2005, J NEUROSURG, V102, P503, DOI 10.3171/jns.2005.102.3.0503 LATIF F, 1993, SCIENCE, V260, P1317, DOI 10.1126/science.8493574 Lonser RR, 2004, NEW ENGL J MED, V350, P2481, DOI 10.1056/NEJMoa040666 Lonser RR, 2003, LANCET, V361, P2059, DOI 10.1016/S0140-6736(03)13643-4 Lustig LR, 2006, OTOL NEUROTOL, V27, P512, DOI 10.1097/00129492-200606000-00013 Malhotra S, 2006, AM J OTOLARYNG, V27, P362, DOI 10.1016/j.amjoto.2006.01.001 Manski TJ, 1997, JAMA-J AM MED ASSOC, V277, P1461, DOI 10.1001/jama.277.18.1461 Megerian CA, 2002, OTOL NEUROTOL, V23, P378, DOI 10.1097/00129492-200205000-00026 Schipper J, 2004, LARYNGO RHINO OTOL, V83, P493, DOI 10.1055/s-2004-814395 Temple RH, 1999, J LARYNGOL OTOL, V113, P161 NR 13 TC 5 Z9 5 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1531-7129 J9 OTOL NEUROTOL JI Otol. Neurotol. PD OCT PY 2007 VL 28 IS 7 BP 927 EP 930 PG 4 WC Clinical Neurology; Otorhinolaryngology SC Neurosciences & Neurology; Otorhinolaryngology GA 216DN UT WOS:000249858400011 PM 17468670 ER PT J AU Stephens, D Kentala, E Varpa, K Pyykko, I AF Stephens, Dafydd Kentala, Erna Varpa, Kirsi Pyykko, Ilmari TI Positive experiences associated with Meniere's disorder SO OTOLOGY & NEUROTOLOGY LA English DT Article DE Meniere's disorder; positive experiences; qualitative study; open-ended questionnaire ID CHRONIC ILLNESS; VERTIGO; QUESTIONNAIRE; SCALE; TINNITUS; DISEASE; LIFE; POPULATION; DISABILITY; HEALTH AB Objective: To investigate whether individuals with Meniere's disorder are able to recognize positive experiences associated with their condition. Study Design and Setting: Open-ended questionnaire sent to a sample of members of the Finnish Meniere Federation. Patients- Two hundred seventy-two members of the Finnish Meniere Federation reporting a diagnosis compatible with the condition. Intervention: Postal questionnaire. Main Outcome Measure: Number of respondents listing positive experiences related to their condition. Categories of responses listed and number of responses within the different categories. Results: One hundred eighty-one responded; 75% of respondents listed positive experiences associated with their Meniere's disorder. These were categorized into 6 themes: (1) Personal Development; (2) Leisure, Lifestyle, and General Health; (3) Managing the Disorder; (4) Meniere's Disease-specific Responses; (5) Meniere's Society-related Responses; and (6) Interrelationships with Others. The largest number of responses (85) was in the Meniere's Disease-specific Responses category and most related to a better understanding of the condition. The most common response in Interrelationships with Others was Empathy with Other Sufferers. The most beneficial with regard to the disease was the answer for Lifestyle because "they have learned to fulfill their own needs." Giving a positive answer was significantly correlated with Quality of Life. Conclusion: Most individuals with Meniere's disorder are able to identify a number of positive experiences associated with the condition. Understanding and having knowledge of these positive experiences help the patients cope with chronic conditions such as Meniere's disorder. Promotion of positive experiences may form a key element to better adjustment to the different symptoms and provide a key element for successful peer support program. C1 Cardiff Univ, Sch Med, Dept Neurol Ophthalmol & Audiol Med, Cardiff, Wales. Univ Helsinki, Cent Hosp, Dept Otorhinolaryngol, Helsinki, Finland. Univ Tampere, Sch Med, Dept Otorhinolaryngol, FIN-33101 Tampere, Finland. Univ Tampere, Sch Med, Dept Comp Sci, FIN-33101 Tampere, Finland. RP Stephens, D (reprint author), Pen & Bryn, Llanilltud Fawr CF61 2XR, Bro Morgannwg, Wales. 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Neurotol. PD OCT PY 2007 VL 28 IS 7 BP 982 EP 987 PG 6 WC Clinical Neurology; Otorhinolaryngology SC Neurosciences & Neurology; Otorhinolaryngology GA 216DN UT WOS:000249858400021 PM 17577129 ER PT J AU Wright, EF AF Wright, Edward F. TI Otologic symptom improvement through TMD therapy SO QUINTESSENCE INTERNATIONAL LA English DT Article DE dizziness; earache; prospective study; temporomandibular joint disorder; temporomandibular joint disorder therapy; tinnitus; treatment outcome; vertigo ID TEMPOROMANDIBULAR DISORDERS; MYOFASCIAL PAIN; TINNITUS; OTALGIA; DYSFUNCTION; DIZZINESS; VERTIGO; MANAGEMENT AB Objectives: Some patients with a temporomandibular disorder (T MID) and coexisting otologic symptoms desire to know the probability of TMD therapy improving their otologic symptoms. The aim of this study was to determine a clinically valid method for identifying which otologic symptoms have a high probability of improving as a result of satisfactory T MD symptom improvement. Method and Materials: Two hundred T MID patients with coexisting tinniltus, otalgia, dizziness, and /or vertigo were asked about their otologic ssymptom characteristics and associations and were given clinical tests, which were speculated to predict otologic symptom response from TMD therapy. The subjects received conserv ative TMD therapy in a manner thought to be most advantageous for their disorders. These potential assessment instruments were then evaluated for their ability to predict otologic symptom improvement. Results: After satisfactory TMD symptom improvement was obtained, the. percent of subjects reporting significant improvement or resolution of their tinnitUS, otalgia, dizziness, and vertigo was 83%, 94%, 91 %, and 100%, respectively. The chi square and Fisher exact probability tests identified significant correlations for tinnitus, otalgia. and dizziness improvement with younger age; for tinnitus and otalgia Improvement with subjects who related that the otologic symptom began when the TMD symptoms began, was worse when the TMD symptoms were worse, and was related to stress; and for dizziness improvement with subjects relating more severe TMD symptoms. Conclusion: Asking T MID patients with coexisting otologic symptoms these specific questions will help practitioners identify which otologic symptoms have a high probability of benefiting from TMD therapy. C1 Univ Texas, Hlth Sci Ctr, Dept Restorat Dent, San Antonio, TX 78229 USA. RP Wright, EF (reprint author), Univ Texas, Hlth Sci Ctr, Dept Restorat Dent, 7703 Floyd Curl Dr,UTHSCSA Mail Code 7890, San Antonio, TX 78229 USA. EM wrighte@uthscsa.edu CR Alkofide Eman A., 1997, Journal of Orofacial Pain, V11, P7 Albino JEN, 1996, J AM DENT ASSOC, V127, P1595 Bjorne A, 2003, CRANIO, V21, P50 CHAN SWY, 1994, CLIN OTOLARYNGOL, V19, P370, DOI 10.1111/j.1365-2273.1994.tb01251.x CHOLE RA, 1992, ARCH OTOLARYNGOL, V118, P817 Costen JB, 1934, ANN OTO RHINOL LARYN, V43, P1 Dworkin Samuel F., 1992, Journal of Craniomandibular Disorders, V6, P301 Eaton DA, 2003, GERIATRICS, V58, P28 GELB H, 1967, J PROSTHET DENT, V18, P497, DOI 10.1016/0022-3913(67)90173-4 Keersmaekers K, 1996, J PROSTHET DENT, V75, P72, DOI 10.1016/S0022-3913(96)90421-7 KELLY HT, 1964, J PROSTHET DENT, V14, P159, DOI 10.1016/0022-3913(64)90131-3 KERSTEIN RB, 1995, CRANIO, V13, P105 Kull RS, 1999, CRANIO, V17, P164 Kuttila M, 2002, ACTA ODONTOL SCAND, V60, P248, DOI 10.1080/000163502760148034 Levine RA, 1999, AM J OTOLARYNG, V20, P351, DOI 10.1016/S0196-0709(99)90074-1 LINSTROM CJ, 1992, OTOLARYNG CLIN N AM, V25, P745 Lockwood AH, 1998, NEUROLOGY, V50, P114 Meyerhoff WL, 1991, OTOLARYNGOLOGY, P1169 MORGAN DH, 1992, CRANIO, V10, P124 MYERS LJ, 1988, CRANIO, V6, P64 OKESON JP, 1996, ACAD OROFACIAL PAIN, P113 OKESON JP, 2003, MANAGEMENT TEMPOROMA, P233 PARKER WS, 1995, AM J ORTHOD DENTOFAC, V107, P153, DOI 10.1016/S0889-5406(95)70130-3 Proudlock FA, 2004, NEUROBIOL AGING, V25, P1377, DOI 10.1016/j.neurobiolaging.2004.02.024 Rubinstein B, 1993, Swed Dent J Suppl, V95, P1 RUBINSTEIN B, 1987, Cranio, V5, P254 SHULMAN A, 1991, TINNITUS DIAGNOSIS T, P387 Shulman A., 1995, INT TINNITUS J, V1, P75 Sloane P D, 1994, J Am Board Fam Pract, V7, P1 Tinetti ME, 2000, ANN INTERN MED, V132, P337 Tuz HH, 2003, AM J ORTHOD DENTOFAC, V123, P620, DOI 10.1016/S0889-5406(03)00153-7 WAZEN JJ, 1989, OTOLARYNG CLIN N AM, V22, P1205 Wright EF, 1997, J AM DENT ASSOC, V128, P1424 WRIGHT EF, 1995, J AM DENT ASSOC, V126, P1030 WRIGHT EF, 2005, MANUAL TEMPOROMANDIB, P5 Wright EF, 2000, MIL MED, V165, P733 NR 36 TC 1 Z9 1 PU QUINTESSENCE PUBLISHING CO INC PI HANOVER PARK PA 4350 CHANDLER DRIVE, HANOVER PARK, IL 60133 USA SN 0033-6572 J9 QUINTESSENCE INT JI Quintessence Int. PD OCT PY 2007 VL 38 IS 9 PG 8 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA 217BY UT WOS:000249924600015 ER PT J AU Hebert, S Carrier, J AF Hebert, Sylvie Carrier, Julie TI Sleep complaints in elderly tinnitus patients: A controlled study SO EAR AND HEARING LA English DT Article ID REACTION QUESTIONNAIRE; PSYCHOLOGICAL PROFILE; QUALITY INDEX; HELP-SEEKING; OLDER-ADULTS; INSOMNIA; DISTRESS; DISTURBANCE; DEPRESSION; VALIDATION AB Objectives: Sleep difficulties are among the most frequent complaints associated with tinnitus. Yet most studies reporting on this problem are rather succinct, and all of them lack proper age- and health-matched control subjects. Design: The present study reports on 102 participants (51 with and 51 without tinnitus), assessed with the Pittsburgh Sleep Quality Index (PSQI), the Beck-II depression inventory, a hyperacusis questionnaire, and a tinnitus-reaction questionnaire (tinnitus group only). Participants were matched for health and relevant socioeconomic factors. Results: Results show that tinnitus patients have greater self-reported sleep difficulties compared with control subjects, specifically sleep efficiency and sleep quality, and that high tinnitus-related distress is associated with greater sleep disturbance. Conclusions: Rather than hearing loss, sleep complaints in this population are mainly explained by hyperacusis, a hallmark of tinnitus, and to a lesser extent by subclinical depressive symptoms. C1 Univ Montreal, Sch Speech Pathol & Audiol, Cent Rech Neuropsychol & Cognit, Montreal, PQ H3C 3J7, Canada. Univ Montreal, Cent Rech Neuropsychol & Cognit, Dept Psychol, Montreal, PQ H3C 3J7, Canada. Inst Univ Geriatrie Montreal, Ctr Rech, Montreal, PQ, Canada. Hop Sacre Coeur, Ctr Etude Sommeil & Rythmes Biol, Montreal, PQ, Canada. RP Hebert, S (reprint author), Univ Montreal, Sch Speech Pathol & Audiol, Cent Rech Neuropsychol & Cognit, POB 6128 Succ Centreville, Montreal, PQ H3C 3J7, Canada. 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PD SEP PY 2007 VL 28 IS 5 BP 649 EP 655 PG 7 WC Audiology & Speech-Language Pathology; Otorhinolaryngology SC Audiology & Speech-Language Pathology; Otorhinolaryngology GA 208QI UT WOS:000249333900005 PM 17804979 ER PT J AU Accorinti, M Pirraglia, MP Corsi, C Caggiano, C AF Accorinti, M. Pirraglia, M. P. Corsi, C. Caggiano, C. TI Vogt-Koyanagi-Harada disease after head trauma SO EUROPEAN JOURNAL OF OPHTHALMOLOGY LA English DT Article DE Vogt-Koyanagi-Harada disease; head trauma; uveitis ID POLYMERASE-CHAIN-REACTION; BARR-VIRUS DNA; CEREBROSPINAL-FLUID AB PURPOSE. To report two cases of Vogt-Koyanagi-Harada disease after closed head trauma. METHODS. Case report. RESULTS. Two patients, one male and one female, developed headache, dysacusis, vertigo, tinnitus, and hair hypersensitivity shortly after a closed head trauma and, 10 and 18 days later, a bilateral uveitis with papillitis and exudative retinal detachment in one and a bilateral mild uveitis with macular exudative detachment in the other. The ocular lesions resolved with intravenous high-dose steroid therapy, but recurred after reduction of the dosages, requiring further steroid therapy. The course of the disease in both patients, with the appearance of fundus depigmentation and pigment clumping, and the occurrence of a concomitant ocular and auditory relapse in one, were typical of Vogt-Koyanagi-Harada disease. CONCLUSIONS. Vogt-Koyanagi-Harada disease may appear after a closed head trauma suggesting that even an indirect trauma in melanocyte-containing tissue may induce an inflammatory response within the eye. C1 [Accorinti, M.; Pirraglia, M. P.; Corsi, C.; Caggiano, C.] Univ Roma La Sapienza, Ocular Immunovirol Serv, Dept Ophthalmol, I-00161 Rome, Italy. RP Accorinti, M (reprint author), Univ Roma La Sapienza, Serv Speciale Immunovirol Oculare, Dipartimento Sci Oftalmol, Viale Policlin 155, I-00161 Rome, Italy. EM massimo.accorinti@tiscalinet.it CR BAGLIVO E, 1998, BR J OPHTHALMOL, V82, P1215 Bassili SS, 1996, RETINA-J RET VIT DIS, V16, P160, DOI 10.1097/00006982-199616020-00013 LUBIN JR, 1981, AM J OPHTHALMOL, V91, P332 NOROSE K, 1990, INVEST OPHTH VIS SCI, V31, P1210 PivettiPezzi P, 1996, AM J OPHTHALMOL, V122, P889 PIVETTIPEZZI P, 2000, UVEITIS 3 MILLENNIUM, P163 RAO NA, 1996, OCULAR INFECT IMMUNI, P734 Rao NA, 1997, EYE, V11, P213 Rathinam SR, 1999, OPHTHALMOLOGY, V106, P635, DOI 10.1016/S0161-6420(99)90129-X Read RW, 2001, AM J OPHTHALMOL, V131, P647, DOI 10.1016/S0002-9394(01)00925-4 SAKAMOTO T, 1991, ARCH OPHTHALMOL-CHIC, V109, P1270 TAGAWA Y, 1978, JPN J OPHTHALMOL, V22, P36 USUI M, 1991, INVEST OPHTH VIS SCI, V32, P807 WEISZ JM, 1995, OPHTHALMOLOGY, V102, P1012 ZIMMERMAN WD, 1993, LARYNGOSCOPE, V103, P87 NR 15 TC 1 Z9 1 PU WICHTIG EDITORE PI MILAN PA 72/74 VIA FRIULI, 20135 MILAN, ITALY SN 1120-6721 J9 EUR J OPHTHALMOL JI Eur. J. Ophthalmol. PD SEP-OCT PY 2007 VL 17 IS 5 BP 847 EP 852 PG 6 WC Ophthalmology SC Ophthalmology GA 251GJ UT WOS:000252360300027 PM 17932867 ER PT J AU Salonen, J Johansson, R Joukamaa, M AF Salonen, Jaakko Johansson, Reijo Joukamaa, Matti TI Alexithymia, depression and tinnitus in elderly people SO GENERAL HOSPITAL PSYCHIATRY LA English DT Article DE alexithymia; depression; tinnitus; hearing loss; elderly people ID GENERAL-POPULATION; FACTORIAL VALIDITY; SCALE; ASSOCIATION; PREVALENCE; HEARING; RELIABILITY; DISORDERS; ADULTS; TRIAL AB Objective: Tinnitus is known to have an association with depression and other psychiatric disorders. As part of a larger epidemiological survey, we evaluated the associations among tinnitus, depression and alexithymia in a group of elderly people. Methods: A survey of hearing loss, audiological rehabilitation and associated morbidity in a senior population was conducted in Turku, Finland. The study sample consisted of 583 participants aged between 70 and 85 years. The Toronto Alexithymia Scale (TAS-20) was used to measure alexithymia, whereas the 13-item version of the Beck Depression Inventory was used to measure depression; the subjective experience of tinnitus was queried with a questionnaire. Results: Depression had a clear association with subjectively annoying tinnitus. Contrary to expectations, the TAS-20 score did not correlate with the severity of tinnitus. In fact, the highest TAS-20 scores were found among the subjects who had tinnitus but did not find it to be subjectively annoying. No significant association between high TAS-20 scores and hearing loss was found. Conclusion: Although we found an association between TAS-20 scores and the presence of tinnitus, alexithymia does not seem to be helpful in explaining tinnitus annoyance among elderly people. (C) 2007 Elsevier Inc. All rights reserved. C1 Turku Univ Cent Hosp, Dept Otorhinolaryngol, FIN-20521 Turku, Finland. Tampere Univ, Tampere Sch Publ Hlth, FIN-33101 Tampere, Finland. Tampere Univ Hosp, Dept Psychiat, Tampere, Finland. RP Salonen, J (reprint author), Turku Univ Cent Hosp, Dept Otorhinolaryngol, POB 52, FIN-20521 Turku, Finland. 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Hosp. Psych. PD SEP-OCT PY 2007 VL 29 IS 5 BP 431 EP 435 DI 10.1016/j.genhosppsych.2007.05.002 PG 5 WC Psychiatry SC Psychiatry GA 217VS UT WOS:000249976000008 PM 17888810 ER PT J AU Mazurek, B Haupt, H Amarjargal, N Yarin, YM Machulik, A Gross, J AF Mazurek, Birgit Haupt, Heidemarle Amarjargal, Nyamaa Yarin, Yuri M. Machulik, Astrid Gross, Johann TI Up-regulation of prestin mRNA expression in the organs of corti of guinea pigs and rats following unilateral impulse noise exposure SO HEARING RESEARCH LA English DT Article DE guinea pig; impulse noise-induced hearing loss; otoacoustic emission; outer hair cell; prestin mRNA; rat ID OUTER HAIR-CELLS; INDUCED HEARING-LOSS; ACUTE ACOUSTIC TRAUMA; MOTOR PROTEIN; GENE-EXPRESSION; OTOACOUSTIC EMISSIONS; COCHLEA; ACETYLCHOLINE; TINNITUS; ELECTROMOTILITY AB Prestin is the motor protein of the outer hair cells (OHCs) and is required for both their electromotility and for cochlear amplification. We investigated the prestin mRNA expression in guinea pigs and rats in relation to the degree of noise-induced hearing loss (NIHL) induced by unilateral impulse noise exposure (167 dB peak SPL) for 2.5-5 min. Distortion product otoacoustic emissions (DPOAE) and auditory brainstem responses were recorded before and one week post exposure. Prestin mRNA was examined by quantitative reverse transcription-polymerase chain reaction. Either the whole organs of Corti or the apical, middle and basal parts were examined separately. The specimens were pooled and grouped according to the degree of NIHL measured in the exposed ears. In rats, the number of hair cells was counted. A clear base-to-apex gradient in the prestin mRNA expression was found to exist in guinea pig and rat controls. In both species, there was an increase in the number of prestin RNA transcripts at a mean NIHL of about 15-25 dB indicating an upregulation in the remaining intact cells. 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Res. PD SEP PY 2007 VL 231 IS 1-2 BP 73 EP 83 DI 10.1016/j.heares.2007.05.008 PG 11 WC Audiology & Speech-Language Pathology; Neurosciences; Otorhinolaryngology SC Audiology & Speech-Language Pathology; Neurosciences & Neurology; Otorhinolaryngology GA 208NU UT WOS:000249327300008 PM 17592749 ER PT J AU Nieves, L Currie, J Hoffman, J Sorosky, JI AF Nieves, L. Currie, J. Hoffman, J. Sorosky, J. I. TI Ototoxicity after intraperitoneal chemotherapy: a case report SO INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER LA English DT Article DE cisplatin toxicity; intraperitoneal chemotherapy; ototoxicity; ovarian cancer ID GYNECOLOGIC-ONCOLOGY-GROUP; STAGE-III OVARIAN; HEARING-LOSS; CISPLATIN; CANCER; PACLITAXEL; TRIAL; TOXICITY AB Recently, the National Cancer Institute endorsed intraperitoneal (IP) therapy as the treatment of choice for optimally debulked epithelial ovarian cancer. However, there are no drug regimens that are clearly indicated, and the exact method of administration has not been established. Furthermore and most importantly, physicians are unaware of what toxicities should be expected with their use of IP therapy. We report a recent unanticipated toxicity from IP cisplatin therapy and review the literature. A 63-year-old female with optimally debulked stage IIIC papillary serous carcinoma of ovary was admitted on postoperative day 14 for her first cycle of IP cisplatin. She received a cisplatin infusion of 100 mg/m(2). Four days after the cycle, she suffered acute onset of bilateral tinnitus and hearing loss (ototoxicity grade 3). Thus, we conclude that high-frequency hearing loss remains a potentially serious and permanent adverse effect of cisplatin. C1 E Carolina Univ, Brody Sch Med, Dept Obstet & Gynecol, Div Gynecol Oncol, Greenville, NC 27834 USA. Hartford Hosp, Dept Obstet & Gynecol, Hartford, CT 06115 USA. 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EM lucybeth-nieves@hotmail.com CR Alberts DS, 1996, NEW ENGL J MED, V335, P1950, DOI 10.1056/NEJM199612263352603 Armstrong DK, 2006, NEW ENGL J MED, V354, P34, DOI 10.1056/NEJMoa052985 Armstrong DK, 2006, GYNECOL ONCOL, V103, P391, DOI 10.1016/j.ygyno.2006.02.029 Bertolini P, 2004, J PEDIAT HEMATOL ONC, V26, P649, DOI 10.1097/01.mph.0000141348.62532.73 Boulikas T, 2004, ONCOL REP, V12, P3 de Bree E, 2006, CANCER TREAT REV, V32, P471, DOI 10.1016/j.ctrv.2006.07.006 Drottar M, 2006, LARYNGOSCOPE, V116, P292, DOI 10.1097/01.mlg.0000197630.85208.36 Markman M, 2001, J CLIN ONCOL, V19, P1001 Rybak LP, 2000, AM J OTOL, V21, P513 SCHAEFER SD, 1985, CANCER, V56, P1934, DOI 10.1002/1097-0142(19851015)56:8<1934::AID-CNCR2820560807>3.0.CO;2-F Walker JL, 2006, GYNECOL ONCOL, V100, P27, DOI 10.1016/j.ygyno.2005.11.013 Weijl NI, 2004, EUR J CANCER, V40, P1713, DOI 10.1016/j.ejca.2004.02.029 NR 12 TC 0 Z9 0 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 1048-891X J9 INT J GYNECOL CANCER JI Int. J. Gynecol. Cancer PD SEP-OCT PY 2007 VL 17 IS 5 BP 133 EP 1135 DI 10.1111/j.1525-1438.2007.00940.x PG 3 WC Oncology; Obstetrics & Gynecology SC Oncology; Obstetrics & Gynecology GA 210WY UT WOS:000249487500028 ER PT J AU Norena, AJ Chery-Croze, S AF Norena, Arnaud Jean Chery-Croze, Sylviane TI Enriched acoustic environment rescales auditory sensitivity SO NEUROREPORT LA English DT Article DE central gain; hearing aid; hearing loss; inhibition; plasticity; recruitment; tinnitus ID COCHLEAR DAMAGE; HYPERACUSIS; TINNITUS; TRAUMA; LOUDNESS; HYPERSENSITIVITY; REORGANIZATION; QUESTIONNAIRE; PLASTICITY; SOUND AB Loudness perception may be controlled by a central gain, possibly dependent on the mean level of the acoustic environment. Owing to hearing loss, for instance, a decrease in sensory inputs could increase this central gain and cause an auditory hypersensitivity or hyperacusis. According to this model, individuals with hyperacusis, provided with an enriched acoustic environment specifically designed to compensate for the decrease in sensory inputs, should show an improvement in their hyperacusis. This study showed that such an enriched acoustic environment indeed decreased auditory hypersensitivity: stimuli initially considered as being too loud became comfortable after a few weeks of acoustic stimulation. Therefore, this original approach could provide a solution to the problem of hyperacusis. C1 Univ Aix Marseille 1, Ctr St Charles, Lab Integrat & Adaptat Neurobiol, CNRS, F-13331 Marseille 03, France. Univ Lyon 1, Neurosci & Sensory Syst Lab, Lyon, France. RP Norena, AJ (reprint author), Univ Aix Marseille 1, Ctr St Charles, Lab Integrat & Adaptat Neurobiol, CNRS, Pole 3C-Case B,3 Pl Victor Hugo, F-13331 Marseille 03, France. 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J., 1995, INTRO PSYCHOL HEARIN Norena A, 2002, AUDIOL NEURO-OTOL, V7, P358, DOI 10.1159/000066156 Norena AJ, 2006, NEUROREPORT, V17, P559, DOI 10.1097/00001756-200604240-00001 Norena AJ, 2005, J NEUROSCI, V25, P699, DOI 10.1523/JNEUROSCI.2226-04.2005 Norena AJ, 2003, HEARING RES, V183, P137, DOI 10.1016/S0378-5955(03)00225-9 Pilgramm M, 1999, P 6 INT TINN SEM CAM, P64 Rasmussen AN, 1998, SCAND AUDIOL, V27, P161, DOI 10.1080/010503998422665 Salvi RJ, 2000, HEARING RES, V147, P261, DOI 10.1016/S0378-5955(00)00136-2 VERNON JA, 1987, AM J OTOL, V8, P201 Wang JA, 2002, HEARING RES, V168, P238, DOI 10.1016/S0378-5955(02)00360-X Wolk C., 1999, P 6 INT TINN SEM LON, P512 Yost W. A., 2006, FUNDAMENTALS HEARING, V5th NR 24 TC 39 Z9 40 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0959-4965 J9 NEUROREPORT JI Neuroreport PD AUG 6 PY 2007 VL 18 IS 12 BP 1251 EP 1255 DI 10.1097/WNR.0b013e3282202c35 PG 5 WC Neurosciences SC Neurosciences & Neurology GA 195BA UT WOS:000248386300010 PM 17632277 ER PT J AU Olthoff, A Laskawi, R Kruse, E AF Olthoff, Arno Laskawi, Rainer Kruse, Eberhard TI Successful treatment of autophonia with botulinum toxin: Case report SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE autophonia; botulinum toxin; impedance audiometry; patulous eustachian tube; tensor veli palatini muscle; tinnitus ID PATULOUS EUSTACHIAN-TUBE; TENSOR VELI PALATINI; MUSCLES; PARALYSIS; ANATOMY AB Objectives: We sought to treat autophonia due to a patulous eustachian tube using botulinum toxin. Methods: Because we assumed that the patulous eustachian tube was caused by abnormal activity of paratubal muscles (tensor and levator veli palatini muscles and salpingopharyngeus muscle), paralysis was performed via injection of botulinum toxin type A in a 45-year-old female professional musician who had had chronic unilateral autophonia for 20 years. In addition to a patient interview, an endoscopic examination of the nasopharynx (posterior rhinoscopy), ear microscopy, and impedance audiometry were performed to verify the diagnosis and the outcome after treatment. Results: The autophonia disappeared 1 week after treatment. Normalized tympanic ventilation was verified by impedance audiometry after 8 weeks. The period of symptom relief was 9 months. Conclusions: The administration of botulinum toxin type A provides a new option in the treatment of patulous eustachian tube. The reliability of this method and the effect of repeated injections remains to be proved in future studies. C1 Univ Gottingen, Dept Phoniatr & Pedaudiol, D-37035 Gottingen, Germany. Univ Gottingen, Dept Otorhinolaryngol, D-3400 Gottingen, Germany. RP Olthoff, A (reprint author), Univ Gottingen, Dept Phoniatr & Pedaudiol, Robert Koch Str 40, D-37035 Gottingen, Germany. 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Otol. Rhinol. Laryngol. PD AUG PY 2007 VL 116 IS 8 BP 594 EP 598 PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA 203GE UT WOS:000248962300007 PM 17847727 ER PT J AU Domachevsky, L Keynan, Y Shupak, A Adir, Y AF Domachevsky, Liran Keynan, Yoav Shupak, Avi Adir, Yochai TI Hyperbaric oxygen in the treatment of sudden deafness SO EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY LA English DT Article DE hyperbaric oxygen therapy; sudden deafness ID SENSORINEURAL HEARING-LOSS; THERAPY; PERILYMPH; EFFICACY AB Currently, the treatment of sudden deafness (SD) is based mainly on complete bed rest and the administration of corticosteroids. Hyperbaric oxygen therapy (HBOT) has previously been suggested as adjunctive treatment. We describe two cases of successful HBOT for SD. The first patient presented with moderate mid-frequency hearing loss without accompanying symptoms, whereas the second patient had moderate low-frequency hearing loss with persistent tinnitus and a single episode of vertigo. HBOT in addition to conventional treatment soon after diagnosis resulted in full recovery of hearing in both patients. The pathogenesis of SD may involve a reduction in cochlear blood flow and perilymph oxygenation, making early HBOT a reasonable treatment modality for this condition. C1 Israel Naval Med Inst, IDF Med Corps, IL-31080 Haifa, Israel. RP Domachevsky, L (reprint author), Israel Naval Med Inst, IDF Med Corps, POB 8040, IL-31080 Haifa, Israel. 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PD AUG PY 2007 VL 264 IS 8 BP 951 EP 953 DI 10.1007/s00405-007-0283-3 PG 3 WC Otorhinolaryngology SC Otorhinolaryngology GA 188OV UT WOS:000247930100019 PM 17361409 ER PT J AU D'Sa, C Gross, J Francone, VP Morest, DK AF D'Sa, Chrystal Gross, Julia Francone, Victor P. Morest, D. Kent TI Plasticity of synaptic endings in the cochlear nucleus following noise-induced hearing loss is facilitated in the adult FGF2 overexpressor mouse SO EUROPEAN JOURNAL OF NEUROSCIENCE LA English DT Article DE axonal degeneration; hair cells; hyperactivity; immunohistochemistry; spiral ganglion; tinnitus ID FIBROBLAST-GROWTH-FACTOR; GUINEA-PIG COCHLEA; CELLS IN-VITRO; ACOUSTIC OVERSTIMULATION; NEURONAL ARCHITECTURE; HIPPOCAMPAL-NEURONS; NEUROTROPHIC FACTOR; GANGLION-CELLS; NERVE ROOT; COMPLEMENTARY ROLES AB In adult mammals a single exposure to loud noise can damage cochlear hair cells and initiate subsequent episodes of degeneration of axonal endings in the cochlear nucleus (CN). Possible mechanisms are loss of trophic support and/or excitotoxicity. Fibroblast growth factor 2 (FGF2), important for development, might be involved in either mechanism. To test this hypothesis, we noise-exposed FGF2 overexpressor mice and observed the effects on synaptic endings by immunolabelling for SV2, a synaptic vesicle protein, at 1, 2, 4, and 8 weeks after noise exposure. SV2 staining was observed in two major locations; perisomatic, representing axo-somatic terminals, and neuropil, representing axo-dendritic terminals. The wildtype (WT) lost both perisomatic and neuropil clusters with an intervening period of modest recovery for the perisomatic. In contrast, in the overexpressor, the perisomatic clusters remained unchanged after intervening periods of increase. The neuropil clusters underwent a period of initial decline, followed by a transient recovery and ultimate decline. 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TOLBERT LP, 1982, NEUROSCIENCE, V7, P3053, DOI 10.1016/0306-4522(82)90229-9 Trettel J, 2001, HANDBOOK OF MOUSE AUDITORY RESEARCH: FROM BEHAVIOR TO MOLECULAR BIOLOGY, P279, DOI 10.1201/9781420038736.ch19 Tureyen K, 2005, NEUROSURGERY, V57, P1254, DOI 10.1227/01.NEU.0000186040.96929.8A WALICKE P, 1986, P NATL ACAD SCI USA, V83, P3012, DOI 10.1073/pnas.83.9.3012 Wei D, 2006, J NEUROBIOL, V67, P108 Wise AK, 2005, J COMP NEUROL, V487, P147, DOI 10.1002/cne.20563 Yoshimura S, 2003, J CLIN INVEST, V112, P1202, DOI 10.1172/JCI200316618 Young ED, 2003, SYNAPTIC ORG BRAIN, P125 Zhou JX, 2007, J COMP NEUROL, V500, P777, DOI 10.1002/cne.21208 Zhou M, 1998, NAT MED, V4, P201, DOI 10.1038/nm0298-201 NR 83 TC 13 Z9 13 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0953-816X J9 EUR J NEUROSCI JI Eur. J. Neurosci. PD AUG PY 2007 VL 26 IS 3 BP 666 EP 680 DI 10.1111/j.1460-9568.2007.05695.x PG 15 WC Neurosciences SC Neurosciences & Neurology GA 197ZZ UT WOS:000248598100014 PM 17651425 ER PT J AU Savastano, M AF Savastano, M. TI Characteristics of tinnitus in childhood SO EUROPEAN JOURNAL OF PEDIATRICS LA English DT Article DE tinnitus characteristics; childhood ID CHILDREN AB Despite its incidence, there are still few reports in literature relating to tinnitus in children. Almost all data were collected by means of questionnaires or in a limited population of children. In order to collect data in a homogeneous way and directly from the patients, the protocol of study proposed by Savastano has been applied to 1,100 children. The results showed tinnitus as present in 374 children but only 6.5% of the cases complained spontaneously about it. In all, 76.4% of the children demonstrated normal hearing, whereas 64.5% reported being bothered by their tinnitus. Tinnitus measurements were obtained and are reproducible in all patients older than 8 years of age. The loudness level was < 10 dB in 48.6% of cases, which was higher than 10 dB in 51.4%. As for the frequency distribution, in most cases it appears to be between 0 and 1,000 Hz. There is a correspondence between the loudness level and masking level. A total inhibition of < 60 s for most children with lower loudness was obtained. The present study demonstrates that the application in the infancy of a specific protocol of study allows the presence of tinnitus to be discovered, giving specific and detailed information about it so as to minimize its damage to be obtained. Moreover, for the first time, data regarding the measurement of tinnitus in childhood has been gathered. C1 Univ Padua, Dept Otolaryngol Head & Neck Surg, I-35128 Padua, Italy. RP Savastano, M (reprint author), Univ Padua, Dept Otolaryngol Head & Neck Surg, I-35128 Padua, Italy. EM marina.savastano@unipd.it CR Aust Gottfried, 2002, Int Tinnitus J, V8, P20 Baguley DM, 1999, INT J PEDIATR OTORHI, V49, P99, DOI 10.1016/S0165-5876(99)00111-1 GRAHAM J, 1981, J LARYNGOL OTOL S, V4, P117 Holgers KM, 2003, EUR J PEDIATR, V162, P276, DOI 10.1007/s00431-003-1183-1 MARTIN K, 1994, BRIT J AUDIOL, V28, P111, DOI 10.3109/03005369409077921 Meikle M, 1984, J Laryngol Otol Suppl, V9, P17 MILLS RP, 1984, INT J PEDIATR OTORHI, V7, P21, DOI 10.1016/S0165-5876(84)80050-6 MILLS RP, 1986, CLIN OTOLARYNGOL, V11, P431, DOI 10.1111/j.1365-2273.1986.tb00147.x NODAR R, 1984, J LARYNGOL OTOL S, V9, P234 Rosanowski F, 1997, HNO, V45, P927, DOI 10.1007/s001060050176 Savastano M, 2002, INT J PEDIATR OTORHI, V64, P23, DOI 10.1016/S0165-5876(02)00031-9 VIANI LG, 1989, J LARYNGOL OTOL, V103, P1142, DOI 10.1017/S0022215100111223 NR 12 TC 18 Z9 20 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013 USA SN 0340-6199 J9 EUR J PEDIATR JI Eur. J. Pediatr. PD AUG PY 2007 VL 166 IS 8 BP 797 EP 801 DI 10.1007/s00431-006-0320-z PG 5 WC Pediatrics SC Pediatrics GA 181WY UT WOS:000247468200006 PM 17109163 ER PT J AU Schaaf, H Hesse, G AF Schaaf, H. Hesse, G. TI Low frequency fluctuating hearing loss without labyrinthine vertigo - a genuine disease? A follow up study after 4 and 10 years SO HNO LA German DT Article DE recurrent low-frequency sensory hearing loss; low-frequency tinnitus; endolymphatic events; Meniere's disease; reactive psychogenic dizziness ID ENDOLYMPHATIC HYDROPS; MENIERES-DISEASE; INNER-EAR; SUDDEN DEAFNESS; DIAGNOSIS AB Background. Besides the typical attacks of dizziness, recurrent low-frequency sensory hearing loss-together with mostly low-frequency tinnitus-is also a characteristic sign of Meniere's disease. It is therefore often assumed to be a prodromal sign of Meniere's disease, even without dizziness. Methods. During our longitudinal study, which was started in 1995, we reported that there were 81 patients with recurrent low-frequency hearing loss with no initial vertigo in the first suspense year of 1999. After a further 6 years, we investigated 46 (57%) of these original 81 patients in the second suspense year, 2005, for new components of vertigo, with the questions of development of Meniere's disease and further development of the patients' hea ring ability and psychic situation in mind. Results. In all, 12 (26%) of the 81 former patients suffered from vertigo, but only 4 ON had developed the typical signs of full-blown Meniere's disease with the typical labyrinthine vertigo. Of the 12 patients who suffered from vertigo, 6 (13% of the 81 with vertigo) were diagnosed with psychogenic vertigo, 1 (1 %) suffered from benign and treatable paroxysmal positional vertigo and 1 (1%) had developed vertigo after acoustic neurinoma surgery. Conclusions. We conclude from our observations that, although almost every patient with Meniere's disease suffers from recurrent low-frequency hearing loss, only a few patients with recurrent hearing loss develop Meniere's disease. However, many patients with low-frequency sensory hearing loss develop anxiety leading to psychogenic dizziness in fearful expectation of "imminent" Meniere's disease. We found that 26% of the patients had persisting bilateral normacusis in the low-frequency ranges, while 34% had unilateral hearing loss that was sufficiently severe to affect their lives and 39%, bilateral hearing loss; however, none of the patients became completely deaf. C1 Tinnitus Klin Arolsen, D-34454 Bad Arolsen, Germany. RP Schaaf, H (reprint author), Tinnitus Klin Arolsen, Grosse Allee 3, D-34454 Bad Arolsen, Germany. 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Fabricius, A. Koesling, S. Bloching, M. TI Intracochlear schwannoma as a cause of a deafness. A case report SO HNO LA German DT Editorial Material DE schwannoma; labyrinth; inner ear; deafness; tinnitus ID INTRALABYRINTHINE SCHWANNOMAS; ACOUSTIC NEUROMA; MANAGEMENT; DIAGNOSIS C1 Univ Halle Wittenberg, Klin & Poliklin Hals Nasen & Ohrenheilkunde Kopf, D-06097 Halle, Germany. Univ Halle Wittenberg, Univ Klin & Poliklin Diagnost Radiol, D-4010 Halle, Germany. RP Knipping, S (reprint author), Univ Halle Wittenberg, Klin & Poliklin Hals Nasen & Ohrenheilkunde Kopf, Magdeburger Str 12, D-06097 Halle, Germany. 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D. Leong, S. C. Arya, A. K. Papouliakos, S. M. Apostolidou, M. T. Issing, W. J. TI 'Complementary ENT': a systematic review of commonly used supplements SO JOURNAL OF LARYNGOLOGY AND OTOLOGY LA English DT Review DE complementary therapies; spirulina; Ginkgo biloba; vitamins; vertigoheel; otolaryngology ID GINKGO-BILOBA; SPIRULINA-PLATENSIS; PILOT RESEARCH; CHILDREN; VERTIGO; METAANALYSIS; SINUSITIS; TINNITUS; TRIALS AB Objective: To assess the evidence surrounding the use of certain complementary supplements in otolaryngology. We specifically focussed on four commonly used supplements: spirulina, Ginkgo biloba, Vertigoheel (R) and nutritional supplements (cod liver oil, multivitamins and pineapple enzyme). Materials and methods: A systematic review of the English and foreign language literature. Inclusion criteria: in vivo human studies. Exclusion criteria: animal trials, in vitro studies and case reports. We also excluded other forms of 'alternative medicine' such as reflexology, acupuncture and other homeopathic remedies. Results: Lack of common outcome measures prevented a formal meta-analysis. Three studies on the effects of spirulina in allergy, rhinitis and immunomodulation were found. One was a double-blind, placebo, randomised, controlled trial (RCT) of patients with allergic rhinitis, demonstrating positive effects in patients fed spirulina for 12 weeks. The other two studies, although non-randomised, also reported a positive role for spirulina in mucosal immunity. Regarding the use of Ginkgo biloba in tinnitus, a Cochrane review published in 2004 showed no evidence for this. The one double-blind, placebo-controlled trial that followed confirmed this finding. Regarding the use of Vertigoheel in vertigo, two double-blind RCTs and a meta-analysis were identified. The first RCT suggested that Vertigoheel was equally effective in reducing the severity, duration and frequency of vertigo compared with betahistine. The second RCT suggested that Vertigoheel was a suitable alternative to G biloba in the treatment of atherosclerosis-related vertigo. A meta-analysis of only four clinical trials confirms that Vertigoheel was equally effective compared with betahistine, G biloba and dimenhydrinate. Regarding multivitamins and sinusitis, two small paediatric pilot studies reported a positive response for chronic sinusitis and otitis media following a course of multivitamins and cod liver oil. Regarding bromelain (pineapple enzyme) and sinusitis, one randomised, multicentre trial including 116 children compared bromelain monotherapy to bromelain with standard therapy and standard therapy alone, for the treatment of acute sinusitis. The bromelain monotherapy group showed a faster recovery compared with the other groups. Conclusion: The positive effects; of spirulina in allergic rhinitis and of Vertigoheel in vertigo are based on good levels of evidence, but larger trials are required. There is overwhelming evidence that G biloba may play no role in tinnitus. There is limited evidence for the use of multivitamins in sinus symptoms, and larger randomised trials are required. C1 Aintree Univ Hosp NHS Fdn Trust, Dept Otolaryngol, Liverpool, Merseyside, England. Royal Natl Throat Nose & Ear Hosp, Dept Otolaryngol, London, England. Univ Athens, Dept Otolaryngol, GR-10679 Athens, Greece. Univ Thessalia, Dept Otolaryngol, Larisa, Greece. Freeman Rd Hosp, Dept Otolaryngol, Newcastle Upon Tyne, Tyne & Wear, England. RP Karkos, PD (reprint author), 36 Hopkinsons Court,Walls Ave, Chester CH1 4LN, Cheshire, England. 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Laryngol. Otol. PD AUG PY 2007 VL 121 IS 8 BP 779 EP 782 DI 10.1017/S00222151.0600449X PG 4 WC Otorhinolaryngology SC Otorhinolaryngology GA 224YV UT WOS:000250485200015 PM 17125579 ER PT J AU Rossi, S De Capua, A Ulivelli, M Bartalini, S Falzarano, V Filippone, G Passero, S AF Rossi, Simone De Capua, Alberto Ulivelli, Monica Bartalini, Sabina Falzarano, Vincenzo Filippone, Giovanni Passero, Stefano TI Effects of repetitive transcranial magnetic stimulation on chronic tinnitus: a randomised, crossover, double blind, placebo controlled study SO JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY LA English DT Article ID POSITRON-EMISSION-TOMOGRAPHY; RESISTANT AUDITORY HALLUCINATIONS; MOTOR CORTEX STIMULATION; CORTICAL SILENT PERIOD; SHORT CASE SERIES; LONG-TERM-MEMORY; PREFRONTAL CORTEX; BRAIN; RTMS; SCHIZOPHRENIA AB Background: Chronic tinnitus is a disabling, almost untreatable, condition, usually accompanied by psychiatric distress. In patients with complex neuropsychiatric diseases, such as chronic pain, with which tinnitus shares pathophysiological similarities, placebo effects may be pronounced. Moreover, it may be difficult to distinguish actual repetitive transcranial magnetic stimulation (rTMS) induced clinical benefits beyond placebo effects in neuropsychiatric patients. Methods: 16 patients with chronic tinnitus underwent a randomised, double blind, crossover, placebo controlled trial of 1 Hz rTMS (120% of motor threshold; 1200 stimuli/day for 5 days) of the left temporoparietal region. Patients were screened for psychiatric comorbidity; additionally, anxiety and depression were monitored throughout the study. Moreover, an original placebo rTMS procedure produced the same activation of ipsilateral face muscles ( a condition which may per se change the subjective rating of tinnitus) as the real rTMS. Results: There were 8 out of 14 responders. Two patients dropped out for transient worsening of tinnitus. Active rTMS induced an overall significant, but transient, improvement (35% of the basal score) of subjective tinnitus perception that was independent of either tinnitus laterality or mood or anxiety changes. No correlations were found between response to rTMS and tinnitus duration, initial subjective score or patient age. When asked after the study was over, 71.4% of patients failed to identify the temporal sequence of the real or sham rTMS interventions. Conclusion: The beneficial effects of rTMS on tinnitus are independent of mood changes. Moreover, they appear in the context of an original placebo stimulation designed to more closely replicate the somatic sensation of active stimulation. Because of the limited temporal duration of the clinical benefit, these neuromodulatory effects could be mediated by transient functional changes taking place in the neural circuits underlying tinnitus processing. C1 Univ Siena, Policlin Scotte, Dipartimento Neurosci, Sez Neurol,Brain Stimulat & Evoked Potentials Lab, I-53100 Siena, Italy. Univ Siena, Dipartimento Neurosci, Sez Psichiatria, I-53100 Siena, Italy. RP Rossi, S (reprint author), Univ Siena, Policlin Scotte, Dipartimento Neurosci, Sez Neurol,Brain Stimulat & Evoked Potentials Lab, Viale Bracci, I-53100 Siena, Italy. 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Neurol. Neurosurg. Psychiatry PD AUG PY 2007 VL 78 IS 8 BP 857 EP 863 DI 10.1136/jnnp.2006.105007 PG 7 WC Clinical Neurology; Psychiatry; Surgery SC Neurosciences & Neurology; Psychiatry; Surgery GA 190IW UT WOS:000248053500018 PM 17314192 ER PT J AU Jagannathan, J Butman, JA Lonser, RR Vortmeyer, AO Zalewski, CK Brewer, C Oldfield, EH Kim, HJ AF Jagannathan, Jay Butman, John A. Lonser, Russell R. Vortmeyer, Alexander O. Zalewski, Christopher K. Brewer, Carmen Oldfield, Edward H. Kim, H. Jeffrey TI Endolymphatic sac tumor demonstrated by intralabyrinthine hemorrhage - Case report SO JOURNAL OF NEUROSURGERY LA English DT Article DE endolymphatic sac tumor; hemorrhage; mechanism; von Hippel-Lindau disease ID HIPPEL-LINDAU-DISEASE; TEMPORAL BONE; NATURAL-HISTORY; LATERAL WALL; HEARING-LOSS; INNER-EAR; HEMANGIOBLASTOMAS; ADENOCARCINOMA; PATIENT AB Endolymphatic sac tumors (ELSTs) are locally invasive neoplasms that arise in the posterior petrous bone and are associated with von Hippel-Lindau (VHL) disease. These tumors cause symptoms even when microscopic in size (below the threshold for detectability on imaging studies) and can lead to symptoms such as hearing loss, tinnitus, vertigo, and facial nerve dysfunction. While the mechanisms of audiovestibular dysfunction in patients harboring ELSTs are incompletely understood, they have critical implications for management. The authors present the case of a 33-year-old man with VHL disease and a 10-year history of progressive tinnitus, vertigo, and left-sided hearing loss. Serial TI weighted magnetic resonance (MR) imaging and computed tomography scans revealed no evidence of tumor, but fluid attenuated inversion recovery (FLAIR) MR imaging sequences obtained after hearing loss demonstrated evidence of left intralabyrinthine hemorrhage. On the basis of progressive disabling audiovestibular dysfunction (tinnitus and vertigo), FLAIR imaging findings, and VHL disease status, the patient underwent surgical exploration of the posterior petrous region, and a small (2-mm) ELST was identified and completely resected. Postoperatively, the patient had improvement of the tinnitus and vertigo. Intralabyrinthine hemorrhage may be an early and the only neuroimaging sign of an ELST in patients with VHL disease and audiovestibular dysfunction. 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Neurosurg. PD AUG PY 2007 VL 107 IS 2 BP 421 EP 425 DI 10.3171/JNS-07/08/0421 PG 5 WC Clinical Neurology; Surgery SC Neurosciences & Neurology; Surgery GA 196XT UT WOS:000248517300026 PM 17695400 ER PT J AU Lopez-Gonzalez, MA Santiago, AM Esteban-Ortega, F AF Lopez-Gonzalez, Miguel A. Santiago, Ana M. Esteban-Ortega, Francisco TI Sulpiride and melatonin decrease tinnitus perception modulating the auditolimbic Dopaminergic pathway SO JOURNAL OF OTOLARYNGOLOGY LA English DT Article DE dopamine; melatonin; neurotransmitters; sulpiride; tinnitus ID VASOACTIVE-INTESTINAL-PEPTIDE; BINDING-SITES; HARDERIAN-GLAND; POSTNATAL-DEVELOPMENT; HUMAN-LYMPHOCYTES; RAT COCHLEA; RECEPTORS; 2-MELATONIN; AMINOGLYCOSIDES; ANTIOXIDANTS AB Objectives: Sulpiride and melatonin decrease dopamine activity. Sulpiride, a D2 antagonist of dopamine receptors, and melatonin, a pineal substance with antidopaminergic action, are administered to tinnitus patients to decrease tinnitus perception. Design: A prospective, randomized, double-blinded, placebo-controlled study was done. Setting: General otorhinolaryngologic consultation for 2002-2004 in Seville, Spain. Methods: One hundred twenty patients consulted for subjective tinnitus. They were included randomly in four groups of 30. One group took sulpiride (50 mg/8 h) alone, the second group took melatonin (3 mg/24 h), the third group took the same doses of sulpiride (50 mg/8 h) plus melatonin (3 mg/24 h), and the fourth group took placebo (lactose 50 mg/8 h), all for 1 month. Ninety-nine patients completed the study. Main Outcome Measures: Clinical history, tonal audiometry, tympanometry, and tinnitometry were done at the beginning and end of the study. Subjective grading of tinnitus perception and a visual analogue scale (0-10) were done for evaluation of results. Results: Based on the subjective grading, tinnitus perception diminished by 56% in patients treated with sulpiride, by 40% in patients treated with melatonin, by 81% in patients treated with sulpiride plus melatonin, and by 22% in patients treated with placebo. Based on the visual analogue scale, tinnitus perception diminished from 7.7 to 6.3 in patients treated with sulpiride, to 6.5 in those treated with melatonin, to 4.8 in patients treated with sulpiride plus melatonin, and to 7.0 in those treated with placebo. Conclusions: Sulpiride and melatonin reduce tinnitus perception, decreasing dopamine activity. The tinnitus auditolimbic dopaminergic pathway has broad therapeutic implications. C1 Virgen Rocio Univ Hosp, Ctr Especialidades Doctor Fleming, Dept Otorhinolaryngol, Seville 41005, Spain. RP Lopez-Gonzalez, MA (reprint author), Virgen Rocio Univ Hosp, Ctr Especialidades Doctor Fleming, Dept Otorhinolaryngol, C Juan Padilla 8, Seville 41005, Spain. 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Otolaryngol. PD AUG PY 2007 VL 36 IS 4 BP 213 EP 219 DI 10.2310/7070.2007.0018 PG 7 WC Otorhinolaryngology SC Otorhinolaryngology GA 222EP UT WOS:000250279200004 PM 17942035 ER PT J AU Andersson, G Svalastog, OK Kaldo, V Sarkohi, A AF Andersson, Gerhard Svalastog, Olav Kyrre Kaldo, Viktor Sarkohi, Ali TI Future thinking in tinnitus patients SO JOURNAL OF PSYCHOSOMATIC RESEARCH LA English DT Article DE tinnitus; cognition; health anxiety; depression; prospective cognitions ID AUTOBIOGRAPHICAL MEMORY; DEPRESSION SCALE; HOSPITAL ANXIETY AB Objective: The purpose of the study was to investigate future thinking in a group of tinnitus patients. It was predicted that participants in the tinnitus group would report fewer positive future events. Methods: A cross-sectional design was used. Two groups of participants completed the test session: tinnitus patients (n=20) and healthy controls (n=20) without tinnitus. Participants completed measures of anticipation of future positive and negative experiences, anxiety and depression. In addition, participants with tinnitus completed a test of tinnitus annoyance. Results: Tinnitus participants generated a greater number of negative future events compared to the controls. There was no difference between the groups on positive future events or on self-reported anxiety, but the tinnitus group scored higher on a depression measure. Controlling for depression scores removed the group difference. Conclusions: While the groups differed on future thinking, the difference concerned negative events, which suggests that anxious information processing might be important in explaining tinnitus annoyance. Levels of depressive symptoms should, however, be considered. (c) 2007 Elsevier Inc. All rights reserved. C1 Linkoping Univ, Dept Behav Sci, SE-58183 Linkoping, Sweden. Linkoping Univ Hosp, Dept Audiol, S-58185 Linkoping, Sweden. 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K., 1999, HDB COGNITION EMOTIO, P267 MacLeod AK, 1997, COGNITION EMOTION, V11, P467 MACLEOD AK, 1993, COGNITIVE THER RES, V17, P441, DOI 10.1007/BF01173056 MCFADDEN D, 1982, FACTS THEORIES TREAT Williams JMG, 1996, MEM COGNITION, V24, P116, DOI 10.3758/BF03197278 WILSON PH, 1991, J SPEECH HEAR RES, V34, P197 ZIGMOND AS, 1983, ACTA PSYCHIAT SCAND, V67, P361, DOI 10.1111/j.1600-0447.1983.tb09716.x NR 18 TC 2 Z9 4 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0022-3999 J9 J PSYCHOSOM RES JI J. Psychosomat. Res. PD AUG PY 2007 VL 63 IS 2 BP 191 EP 194 DI 10.1016/j.jpsychores.2007.02.012 PG 4 WC Psychiatry SC Psychiatry GA 198RD UT WOS:000248644300012 PM 17662756 ER PT J AU Kaldo, V Cars, S Rahnert, M Larsen, HC Andersson, G AF Kaldo, Viktor Cars, Sofia Rahnert, Miriam Larsen, Hans Christian Andersson, Gerhard TI Use of a self-help book with weekly therapist contact to reduce tinnitus distress: A randomized controlled trial SO JOURNAL OF PSYCHOSOMATIC RESEARCH LA English DT Article DE self-help; bibliotherapy; cognitive-behavior therapy; audiology; tinnitus ID PSYCHOLOGICAL TREATMENTS; HOSPITAL ANXIETY; DEPRESSION SCALE; METAANALYSIS; MANAGEMENT AB Objective: Tinnitus distress can be reduced by means of cognitive-behavior therapy (CBT). To compensate for the shortage of CBT therapists, we aimed, in this study, to investigate the effects of a CBT-based self-help book guided by brief telephone support. Methods: Seventy-two patients were randomized either to a self-help book and seven weekly phone calls or to a wait-list control condition, later on receiving the self-help book with less therapist support. The dropout rate was 7%. Follow-up data I year after completion of treatment were also collected (12% dropout). The Tinnitus Reaction Questionnaire (TRQ) was the main outcome measure, complemented with daily ratings of tinnitus and measures of insomnia, anxiety, and depression. Results: On the TRQ, significant reductions were found in the treatment group both immediately following treatment and at I-year follow-up. In the treatment group, 32% reached the criteria for clinical significance (at least 50% reduction of the TRQ) compared to 5% in the wait-list group. Directly after treatment, two out of five measures showed significant differences in favor of the treatment with more therapist support compared with the group who, after their waiting period, received little therapist support. The self-help treatment was estimated to be 2.6 (seven phone calls) and 4.8 (one phone call) times as cost-effective as regular CBT group treatment. Conclusions: Guided self-help can serve as an alternative way to administer CBT for tinnitus. Preliminary results cast some doubts on the importance of weekly therapist contact. The effect size was somewhat smaller than for regular CBT, but on the other hand, the self-help seems far more cost-effective. Future studies should compare treatment modalities directly and explore cost-effectiveness more thoroughly. (c) 2007 Elsevier Inc. All rights reserved. C1 Uppsala Univ, Dept Psychol, SE-75142 Uppsala, Sweden. Univ Uppsala Hosp, Dept Audiol, Uppsala, Sweden. Linkoping Univ, Dept Behav Sci & Learning, Linkoping, Sweden. RP Kaldo, V (reprint author), Uppsala Univ, Dept Psychol, Box 1225, SE-75142 Uppsala, Sweden. 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Psychosomat. Res. PD AUG PY 2007 VL 63 IS 2 BP 195 EP 202 DI 10.1016/j.jpsychores.2007.04.007 PG 8 WC Psychiatry SC Psychiatry GA 198RD UT WOS:000248644300013 PM 17662757 ER PT J AU Lefaucheur, JP Brugieres, P Menard-Lefaucheur, I Wendling, S Pommier, M Bellivier, F AF Lefaucheur, J. -P. Brugieres, P. Menard-Lefaucheur, I. Wendling, S. Pommier, M. Bellivier, F. TI The value of navigation-guided rTMS for the treatment of depression: An illustrative case SO NEUROPHYSIOLOGIE CLINIQUE-CLINICAL NEUROPHYSIOLOGY LA French DT Article DE Broca's area; coil placement; cortical stimulation; magnetic resonance; imaging; major depression; speech; transcranial magnetic; stimulation ID TRANSCRANIAL MAGNETIC STIMULATION; PRIMARY MOTOR CORTEX; PREFRONTAL CORTEX; GLUCOSE-METABOLISM; CHRONIC TINNITUS; DOUBLE-BLIND; TMS; INTERFERENCE; REDUCTION; EFFICACY AB Repetitive transcranial magnetic stimulation (rTMS) of the prefrontal cortex has been thought to have great potential to treat refractory depression since the first studies published ten years ago. However, one of the potential limitations of rTMS is the poor definition of the localization of the prefrontal cortical target, which is based on a rather simplistic anatomical approach, i.e., 5cm anterior to the primary motor cortical representation of the hand. This "standard procedure" does not take into consideration interindividual variations in brain morphology. We report the case of a 40-year-old woman who underwent two weeks of 10Hz-rTMS for the treatment of a major, drug-resistant depressive episode. The rTMS target was determined with the "standard procedure" for the first week and with a dedicated navigation system as the left Brodmann area 46 for the second week. The clinical assessment of antidepressant effects was performed before and after each week of stimulation. Following the first week of stimulation, the patient improved, in particular regarding speech production. Using the navigation system, the location of the target stimulated during the first week was found to correspond to Broca's area, and not to the prefrontal area as intended. Antidepressant effects were more marked after the second week of navigated rTMS. In the present case, the prefrontal target was situated 8.3 cm anterior to hand motor cortex. This illustrates that the "standard procedure" may inaccurately target the prefrontal cortex, although resulting in antidepressant-like effects. The use of navigation systems should limit the variability of the results reported so far in the treatment of depression by rTMS. (c) 2007 Elsevier Masson SAS. All rights reserved. C1 [Lefaucheur, J. -P.; Menard-Lefaucheur, I.; Wendling, S.] CHU Henri Mondor, Serv Physiol Explorat Fonct, F-94010 Creteil, France. [Brugieres, P.] CHU Henri Mondor, Serv Neuroradiol, F-94010 Creteil, France. [Pommier, M.] CHU Henri Mondor, Serv Ingn Biomed, F-94010 Creteil, France. [Bellivier, F.] CHU Henri Mondor, Serv Psychiat, F-94010 Creteil, France. RP Lefaucheur, JP (reprint author), CHU Henri Mondor, Serv Physiol Explorat Fonct, AP-HP, F-94010 Creteil, France. 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PD AUG-SEP PY 2007 VL 37 IS 4 BP 265 EP 271 DI 10.1016/j.neucli.2007.07.003 PG 7 WC Clinical Neurology; Neurosciences; Physiology SC Neurosciences & Neurology; Physiology GA 241MB UT WOS:000251659400006 PM 17996815 ER PT J AU Smits, M Kovacs, S de Ridder, D Peeters, RR van Hecke, P Sunaert, S AF Smits, Marion Kovacs, Silvia de Ridder, Dirk Peeters, Ronald R. van Hecke, Paul Sunaert, Stefan TI Lateralization of functional magnetic resonance imaging (fMRI) activation in the auditory pathway of patients with lateralized tinnitus SO NEURORADIOLOGY LA English DT Article DE magnetic resonance imaging; tinnitus; auditory pathways; inferior colliculus; auditory diseases, central ID POSITRON-EMISSION-TOMOGRAPHY; CUTANEOUS-EVOKED TINNITUS; TIME-SERIES; ELECTRICAL-STIMULATION; ACOUSTIC NOISE; CORTEX; PERCEPTION; REORGANIZATION; PLASTICITY; ASYMMETRY AB Introduction Tinnitus is hypothesized to be an auditory phantom phenomenon resulting from spontaneous neuronal activity somewhere along the auditory pathway. We performed fMRI of the entire auditory pathway, including the inferior colliculus (IC), the medial geniculate body (MGB) and the auditory cortex (AC), in 42 patients with tinnitus and 10 healthy volunteers to assess lateralization of fMRI activation. Methods Subjects were scanned on a 3T MRI scanner. A T2*-weighted EPI silent gap sequence was used during the stimulation paradigm, which consisted of a blocked design of 12 epochs in which music presented binaurally through headphones, which was switched on and off for periods of 50 s. Using SPM2 software, single subject and group statistical parametric maps were calculated. Lateralization of activation was assessed qualitatively and quantitatively. Results Tinnitus was lateralized in 35 patients (83%, 13 right-sided and 22 left-sided). Significant signal change (P-corrected < 0.05) was found bilaterally in the primary and secondary AC, the IC and the MGB. Signal change was symmetrical in patients with bilateral tinnitus. In patients with lateralized tinnitus, fMRI activation was lateralized towards the side of perceived tinnitus in the primary AC and IC in patients with right-sided tinnitus, and in the MGB in patients with left-sided tinnitus. In healthy volunteers, activation in the primary AC was left-lateralized. Conclusion Our paradigm adequately visualized the auditory pathways in tinnitus patients. In lateralized tinnitus fMRI activation was also lateralized, supporting the hypothesis that tinnitus is an auditory phantom phenomenon. C1 Univ Med Ctr Rotterdam, Erasmus MC, Dept Radiol, NL-3015 CE Rotterdam, Netherlands. Catholic Univ Louvain, Univ Hosp, Dept Radiol, B-3000 Louvain, Belgium. Univ Antwerp, Dept Neurosurg, Edegem, Belgium. RP Smits, M (reprint author), Univ Med Ctr Rotterdam, Erasmus MC, Dept Radiol, Hs 224,Gravendijkwal 230, NL-3015 CE Rotterdam, Netherlands. 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TI Lateralization of neural activity associated with tinnitus SO NEURORADIOLOGY LA English DT Letter ID TRANSCRANIAL MAGNETIC STIMULATION; AUDITORY-CORTEX; INTRACTABLE TINNITUS; ACTIVATION C1 Oregon Hlth & Sci Univ, Dept Otolaryngol, OHSU Tinnitus Clin, Portland, OR 97239 USA. RP Folmer, RL (reprint author), Oregon Hlth & Sci Univ, Dept Otolaryngol, OHSU Tinnitus Clin, 3181 SW Sam Jackson Pk Rd,Mail Code NRC04, Portland, OR 97239 USA. EM folmerr@ohsu.edu RI Folmer, Robert/E-3105-2010 CR Andersson G, 2002, CLIN PSYCHOL REV, V22, P977, DOI 10.1016/S0272-7358(01)00124-6 Arnold W, 1996, ORL J OTO-RHINO-LARY, V58, P195 De Ridder D, 2005, OTOL NEUROTOL, V26, P616, DOI 10.1097/01.mao.0000178146.91139.3c De Ridder D, 2006, ORL J OTO-RHINO-LARY, V68, P48, DOI 10.1159/000090491 De Ridder D, 2005, OTOL NEUROTOL, V26, P1262, DOI 10.1097/01.mao.0000194897.56592.11 De Ridder D, 2004, J NEUROSURG, V100, P560, DOI 10.3171/jns.2004.100.3.0560 Folmer R. 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Kovacs, S. Smits, M. Peeters, R. Van Hecke, P. Sunaert, S. TI Comment on Dr. Folmer's letter to the editor entitled "Lateralization of neural activity associated with tinnitus" SO NEURORADIOLOGY LA English DT Letter ID AUDITORY-CORTEX; VISUAL-CORTEX; ACTIVATION; BRAIN; PAIN; PERCEPTION C1 Catholic Univ Louvain, Univ Hosp, Dept Radiol, B-3000 Louvain, Belgium. Univ Antwerp, Dept Neurosurg, Edegem, Belgium. Erasmus MC, Dept Radiol, Rotterdam, Netherlands. RP Sunaert, S (reprint author), Catholic Univ Louvain, Univ Hosp, Dept Radiol, B-3000 Louvain, Belgium. EM Stefan.Sunaert@uzleuven.be RI Smits, Marion/E-4795-2011; Sunaert, Stefan/E-8031-2011 CR Arnold W, 1996, ORL J OTO-RHINO-LARY, V58, P195 Brookes MJ, 2005, NEUROIMAGE, V26, P302, DOI 10.1016/j.neuroimage.2005.01.050 Crone NE, 2001, CLIN NEUROPHYSIOL, V112, P565, DOI 10.1016/S1388-2457(00)00545-9 Damoiseaux JS, 2006, P NATL ACAD SCI USA, V103, P13848, DOI 10.1073/pnas.0601417103 DERIDDER S, 2006, ORL J OTORHINOLARYNG, V68, P48 FOLMER RL, 2007, NEURORADIOLOGY GRAY CM, 1989, P NATL ACAD SCI USA, V86, P1698, DOI 10.1073/pnas.86.5.1698 Greicius MD, 2003, P NATL ACAD SCI USA, V100, P253, DOI 10.1073/pnas.0135058100 JOLIOT M, 1994, P NATL ACAD SCI USA, V91, P11748, DOI 10.1073/pnas.91.24.11748 LACHAUX JP, 2007, HUM BRAIN MAPP Llinas RR, 1999, P NATL ACAD SCI USA, V96, P15222, DOI 10.1073/pnas.96.26.15222 Lockwood AH, 1998, NEUROLOGY, V50, P114 Maihofner C, 2005, PAIN, V114, P93, DOI 10.1016/j.pain.2004.12.001 Maihofner C, 2004, EUR J NEUROSCI, V19, P3211, DOI 10.1111/j.1460-9568.2004.03437.x Melcher JR, 2000, J NEUROPHYSIOL, V83, P1058 Moller A R, 2000, J Am Acad Audiol, V11, P115 Moller AR, 1997, AM J OTOL, V18, P577 Muhlnickel W, 1998, P NATL ACAD SCI USA, V95, P10340, DOI 10.1073/pnas.95.17.10340 TONNDORF J, 1987, HEARING RES, V28, P271, DOI 10.1016/0378-5955(87)90054-2 Weisz N, 2007, J NEUROSCI, V27, P1479, DOI 10.1523/JNEUROSCI.3711-06.2007 NR 20 TC 0 Z9 0 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013 USA SN 0028-3940 J9 NEURORADIOLOGY JI Neuroradiology PD AUG PY 2007 VL 49 IS 8 BP 693 EP 696 DI 10.1007/s00234-007-0258-5 PG 4 WC Clinical Neurology; Neuroimaging; Radiology, Nuclear Medicine & Medical Imaging SC Neurosciences & Neurology; Radiology, Nuclear Medicine & Medical Imaging GA 194FE UT WOS:000248329000010 ER PT J AU Brackmann, DE Doherty, JK AF Brackmann, Derald E. Doherty, Joni K. TI Facial palsy and fallopian canal expansion associated with idiopathic intracranial hypertension SO OTOLOGY & NEUROTOLOGY LA English DT Article DE benign intracranial hypertension; cerebrospinal fluid expansion; facial palsy; fallopian canal; headache; hearing loss; idiopathic intracranial hypertension; pseudotumor cerebri; tinnitus ID PSEUDOTUMOR CEREBRI; OTORRHEA AB Objective: Describe neurotologic findings associated with idiopathic intracranial hypertension (IIH). Study Design: Retrospective. Setting: Tertiary referral center. Patients: Case of IIH (> 250 mm water) presenting with unilateral facial palsy and enlargement of the fallopian canal on computed tomography and magnetic resonance imaging. Intervention(s): Oral acetazolamide, corticosteroids, and cerebrospinal fluid drainage. Main outcome measure(s): Intracranial pressure measurement, cranial nerve examination, audiometry, and symptom assessment. Results: Audiometry revealed asymmetric sensorineural hearing loss. Enlargement of the fallopian canal with cerebrospinal fluid was evident on imaging studies. Partial resolution of IIH symptoms was achieved. Conclusion: IIH is an enigmatic disease entity. Increased intracranial pressure usually presents with headache and pulsatile tinnitus and is occasionally associated with cranial neuropathies. Abducens palsy is most common, producing diplopia. Cranial nerve involvement is often asymmetric, producing false localizing signs. Facial paralysis is an uncommon sequela of IIH. Treatment of IIH consists of reducing intracranial pressure. Corticosteroids are recommended for treatment of facial paralysis. C1 House Clin, Los Angeles, CA 90057 USA. House Ear Res Inst, Los Angeles, CA 90057 USA. Univ Calif San Diego, Div Otolaryngol Head & Neck Surg, La Jolla, CA USA. RP Brackmann, DE (reprint author), House Clin, 5th Floor,2100 W 3rd St, Los Angeles, CA 90057 USA. EM dbrackmann@hei.org CR Bandyopadhyay S, 2002, J NEURO-OPHTHALMOL, V22, P9, DOI 10.1097/00041327-200203000-00003 Binder DK, 2004, NEUROSURGERY, V54, P538, DOI 10.1227/01.NEU.0000109042.87246.3C Capobianco DJ, 1997, HEADACHE, V37, P286, DOI 10.1046/j.1526-4610.1997.3705286.x Dandy WE, 1937, ANN SURG, V106, P492, DOI 10.1097/00000658-193710000-00002 FOLEY J, 1955, BRAIN, V78, P1, DOI 10.1093/brain/78.1.1 Foyt D, 2000, ARCH OTOLARYNGOL, V126, P540 GACEK RR, 1979, ANN OTO RHINOL LARYN, V88, P358 Gordon K, 1997, CAN J NEUROL SCI, V24, P219 Marcus DM, 2001, J NEURO-OPHTHALMOL, V21, P121, DOI 10.1097/00041327-200106000-00014 Rudnick E, 2005, OTOL NEUROTOL, V26, P166, DOI 10.1097/00129492-200503000-00006 Sugerman HJ, 1999, ANN SURG, V229, P634, DOI 10.1097/00000658-199905000-00005 NR 11 TC 4 Z9 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1531-7129 J9 OTOL NEUROTOL JI Otol. Neurotol. PD AUG PY 2007 VL 28 IS 5 BP 715 EP 718 DI 10.1097/01.mao.0000281801.51821.27 PG 4 WC Clinical Neurology; Otorhinolaryngology SC Neurosciences & Neurology; Otorhinolaryngology GA 197LY UT WOS:000248558300021 PM 17667777 ER PT J AU Pal, PK Lakshmi, PS Nirmala, M AF Pal, Pramod Kumar Lakshmi, Ponnathpur Satish Nirmala, Muninarayanappa TI Efficacy and complication of botulinum toxin injection in palatal myoclonus: Experience from a patient SO MOVEMENT DISORDERS LA English DT Article DE palatal myoclonus; palatal tremor; botulinum toxin; palatal palsy ID TREMOR; TINNITUS; GIRL AB We report the outcome of botulinum toxin injection for essential palatal myoclonus, given on two occasions over a period of one year, in an eight-year-old boy, the youngest patient treated with botulinum toxin to date. Though there was significant relief of ear clicks each time after the injection, he developed severe palatal palsy following the second injection, which persisted for a month. We suggest that appropriate caution needs to be exercised when repeating botulinum toxin injections for palatal myoclonus in children. (c) 2007 Movement Disorder Society. C1 Natl Inst Mental Hlth & Neurosci, Dept Neurol, Bangalore 560029, Karnataka, India. Sagar Apollo Hosp, Dept Otolaryngol, Bangalore, Karnataka, India. RP Pal, PK (reprint author), Natl Inst Mental Hlth & Neurosci, Dept Neurol, Bangalore 560029, Karnataka, India. EM palpramod@hotmail.com CR Bryce GE, 1998, J OTOLARYNGOL, V27, P213 Cho JW, 2001, MOVEMENT DISORD, V16, P779, DOI 10.1002/mds.1132 DEUSCHL G, 1991, NEUROLOGY, V41, P1677 Ensink RJH, 2003, OTOL NEUROTOL, V24, P714, DOI 10.1097/00129492-200309000-00003 Jamieson DRS, 1996, NEUROLOGY, V46, P1168 Jero J, 2000, ACTA OTO-LARYNGOL, P61 Krause E, 2006, OTOL NEUROTOL, V27, P672 Penney SE, 2006, J NEUROL, V253, P857, DOI 10.1007/s00415-006-0039-9 SAEED SR, 1993, J LARYNGOL OTOL, V107, P208, DOI 10.1017/S0022215100122650 Srirompotong Supaporn, 2002, Journal of the Medical Association of Thailand, V85, P392 Varney SM, 1996, OTOLARYNG HEAD NECK, V114, P317, DOI 10.1016/S0194-5998(96)70194-8 NR 11 TC 4 Z9 4 PU WILEY-LISS PI HOBOKEN PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0885-3185 J9 MOVEMENT DISORD JI Mov. Disord. PD JUL 30 PY 2007 VL 22 IS 10 BP 1484 EP 1486 DI 10.1002/mds.21405 PG 3 WC Clinical Neurology SC Neurosciences & Neurology GA 197BJ UT WOS:000248527800018 PM 17516476 ER PT J AU Langguth, B Kleinjung, T Marienhagen, J Binder, H Sand, PG Hajak, G Eichhammer, P AF Langguth, Berthold Kleinjung, Tobias Marienhagen, Joerg Binder, Harald Sand, Philipp G. Hajak, Goeran Eichhammer, Peter TI Transcranial magnetic stimulation for the treatment of tinnitus: Effects on cortical excitability SO BMC NEUROSCIENCE LA English DT Article ID LONG-TERM DEPRESSION; HUMAN MOTOR CORTEX; POSITRON-EMISSION-TOMOGRAPHY; CUTANEOUS-EVOKED TINNITUS; AUDITORY-CORTEX; ELECTROCONVULSIVE-THERAPY; INTRACTABLE TINNITUS; MAJOR DEPRESSION; THALAMIC NEURONS; REPETITIVE TMS AB Background: Low frequency repetitive transcranial magnetic stimulation ( rTMS) has been proposed as an innovative treatment for chronic tinnitus. The aim of the present study was to elucidate the underlying mechanism and to evaluate the relationship between clinical outcome and changes in cortical excitability. We investigated ten patients with chronic tinnitus who participated in a sham- controlled crossover treatment trial. Magnetic- resonance- imaging and positronemissiontomography guided 1 Hz rTMS were performed over the auditory cortex on 5 consecutive days. Active and sham treatments were separated by one week. Parameters of cortical excitability ( motor thresholds, intracortical inhibition, intracortical facilitation, cortical silent period) were measured serially before and after rTMS treatment by using single- and paired- pulse transcranial magnetic stimulation. Clinical improvement was assessed with a standardized tinnitusquestionnaire. Results: We noted a significant interaction between treatment response and changes in motor cortex excitability during active rTMS. Specifically, clinical improvement was associated with an increase in intracortical inhibition, intracortical facilitation and a prolongation of the cortical silent period. These results indicate that intraindividual changes in cortical excitability may serve as a correlate of response to rTMS treatment. Conclusion: The observed alterations of cortical excitability suggest that low frequency rTMS may evoke long- term- depression like effects resulting in an improvement of subcortical inhibitory function. C1 Univ Regensburg, Dept Psychiat Psychosomat & Psychotherapy, D-93053 Regensburg, Germany. Univ Regensburg, Dept Otorhinolaryngol & Audiol, D-93053 Regensburg, Germany. Univ Regensburg, Dept Nucl Med, D-93053 Regensburg, Germany. Univ Freiburg, Dept Med Biometry & Stat, D-79104 Freiburg, Germany. RP Langguth, B (reprint author), Univ Regensburg, Dept Psychiat Psychosomat & Psychotherapy, Univ Str 84, D-93053 Regensburg, Germany. 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10.1111/j.1469-7793.1999.0591t.x Xu L, 1997, NATURE, V387, P497, DOI 10.1038/387497a0 Ziemann U, 1998, J NEUROSCI, V18, P1115 Ziemann U., 2000, TRANSCRANIAL MAGNETI, P45 Ziemann U, 2001, BRAIN, V124, P1171, DOI 10.1093/brain/124.6.1171 NR 72 TC 33 Z9 35 PU BIOMED CENTRAL LTD PI LONDON PA MIDDLESEX HOUSE, 34-42 CLEVELAND ST, LONDON W1T 4LB, ENGLAND SN 1471-2202 J9 BMC NEUROSCI JI BMC Neurosci. PD JUL 2 PY 2007 VL 8 AR 45 DI 10.1186/1471-2202-8-45 PG 12 WC Neurosciences SC Neurosciences & Neurology GA 196ID UT WOS:000248474000001 PM 17605764 ER PT J AU Mrena, R Ylikoski, M Makitie, A Pirvola, U Ylikoshi, J AF Mrena, Roderik Ylikoski, Matti Makitie, Antti Pirvola, Ulla Ylikoshi, Jukka TI Occupational noise-induced hearing loss reports and tinnitus in Finland SO ACTA OTO-LARYNGOLOGICA LA English DT Article DE acoustic trauma; disability; industrial; threshold shift ID COMPENSATION; WORKERS AB Conclusion. In occupational noise-induced hearing loss (NIHL) reports, many tinnitus sufferers probably remain undetected and untreated at present. Attention should be focused on tinnitus, as well as threshold shifts resulting from NIHL. Objectives. Occupational NIHL is frequent among workers in industrialized countries and it is one of the greatest occupational health hazards. Hearing conservation programs have led to a reduction in the numbers of severe occupational NIHL. Our objectives were to analyze the severity of occupational NIHL reported in Finland, identify risk occupations, and investigate the occurrence of tinnitus among the reported cases. Materials and methods. We examined the records of 857 NIHL cases with an identifiable disability category of the total 858 NIHL cases reported in 2000. We sent tinnitus questionnaires to 366 of these NIHL cases. Results. The degree of speech-frequency hearing loss was generally low, and a mention of tinnitus was reported in only 34 cases (4.0%). However, 88.7% of the patients actually had unreported tinnitus. C1 Univ Helsinki, Cent Hosp, Dept ORL, Helsinki, Finland. Inst Occupat Hlth, Helsinki, Finland. Univ Helsinki, Inst Biotechnol, Helsinki, Finland. Medivire Oy, Jyvaskyla 40100, Finland. RP Mrena, R (reprint author), Medivire Oy, Asemakatu 12, Jyvaskyla 40100, Finland. 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PD JUL PY 2007 VL 127 IS 7 BP 729 EP 735 DI 10.1080/00016480601002013 PG 7 WC Otorhinolaryngology SC Otorhinolaryngology GA 195MF UT WOS:000248415600009 PM 17573569 ER PT J AU Topuz, B Ogmen, G Ardic, FN Kara, CO AF Topuz, Buelent Oegmen, Guelsen Ardic, Fazill Necdet Kara, Cueneyt Orhan TI Provocation of Endolymphatic hydrops with a prick test in Meniere's disease SO ADVANCES IN THERAPY LA English DT Article DE Meniere's disease; prick test; allergy ID ELECTROCOCHLEOGRAPHY; CHALLENGE; ALLERGY AB This study was conducted to test the hypothesis that antigenic challenge is an important stimulative factor for an episode of endolymphatic hydrops. The study was held in a tertiary care center for patients with probable or definite Meniere's disease. The prick test, which included dietary and inhalant allergens, was applied to all patients with a Multi-Test Applicator (Lincoln Diagnostics, Decatur, III). Patients were tested with electrocochleography before and after the prick test. The positive allergen was diluted in 1/10 of a prick test dose, and patients were provoked and tested again. A negative summating potential/action potential (SP/AP) amplitude ratio greater than 0.5 was used as the main outcome measure. Pretest, posttest, and postprovocation SP/AP amplitude ratios were compared. A total of 80 diseased and 16 normal ears of 48 patients with Meniere's disease were assessed. All patients were found to be atopic, but none had allergic symptoms. No symptom like vertigo or fullness was seen after the prick test was performed. In all, 30 patients had tinnitus and fullness in the diseased ear, and 6 patients had vertigo after the provocation. The SP/AP ratio was greater than 0.50 in 23 diseased (29%) and 3 normal (19%) ears before the prick test. After the prick test, 62 diseased (78%) and 13 normal (81 %) ears had endolymphatic hydrops. These numbers did not change much after the provocation. Results reported here support the role of antigenic stimulation for episodes of Meniere's disease. Endolymphatic hydrops was the atopic reaction that occurred in most study patients. C1 Pamukkale Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, Denizli, Turkey. RP Kara, CO (reprint author), Pamukkale Univ Hastanesi, KBB Klinigi, Klinigi Kampusu, TR-20010 Denizli, Turkey. EM cokara@yahoo.com CR Derebery MJ, 2000, OTOLARYNG HEAD NECK, V122, P174, DOI 10.1016/S0194-5998(00)70235-X Derebery MJ, 2000, OTOLARYNG HEAD NECK, V123, P69, DOI 10.1067/mhn.2000.105715 DEREBERY MJ, 1992, OTOLARYNG CLIN N AM, V25, P213 Ferraro J A, 1999, Am J Audiol, V8, P21, DOI 10.1044/1059-0889(1999/001) FERRARO JA, 1985, ARCH OTOLARYNGOL, V111, P71 Gibbs SR, 1999, OTOLARYNG HEAD NECK, V121, P283, DOI 10.1016/S0194-5998(99)70186-5 Hallpike C. S., 1938, J LARYNG, V53, P625, DOI 10.1017/S0022215100003947 Howard BK, 1997, OTOLARYNG HEAD NECK, V117, P653, DOI 10.1016/S0194-5998(97)70048-2 MONSELL EM, 1995, OTOLARYNG HEAD NECK, V113, P181 Pappas DG, 2000, AM J OTOL, V21, P81, DOI 10.1016/S0196-0709(00)80079-4 RUTH RA, 1988, AM J OTOL, V9, P1 Sin A, 1997, Allergol Immunopathol (Madr), V25, P80 VISCOMI GJ, 1992, OTOLARYNG HEAD NECK, V107, P733 ZHU X, 1990, ANN OTO RHINOL LARYN, V99, P535 NR 14 TC 2 Z9 2 PU HEALTH COMMUNICATIONS INC PI EDISON PA 292 FERNWOOD AVE, EDISON, NJ 08837 USA SN 0741-238X J9 ADV THER JI Adv. Ther. PD JUL-AUG PY 2007 VL 24 IS 4 BP 819 EP 825 DI 10.1007/BF02849975 PG 7 WC Medicine, Research & Experimental; Pharmacology & Pharmacy SC Research & Experimental Medicine; Pharmacology & Pharmacy GA 230TG UT WOS:000250898200014 PM 17901031 ER PT J AU Herraiz, C Hernandez, FJ Toledano, A Aparicio, JM AF Herraiz, Carlos Hernandez, F. Javier Toledano, Adolfo Aparicio, Jose M. TI Tinnitus retraining therapy: prognosis factors SO AMERICAN JOURNAL OF OTOLARYNGOLOGY LA English DT Article ID NEUROPHYSIOLOGICAL APPROACH AB Introduction: Tinnitus retraining therapy (TRT) is, nowadays, one of the most extended treatments for tinnitus control. The goal is the habituation to a nonsignificative signal, that is, tinnitus, first, eliminating its reaction and, second, minimizing its perception. Purpose: The objective of this study is to identify the factors that Could improve or reduce the efficacy of TRY Materials and methods: A prospective nonrandomized clinical assay (n = 137) was conducted. Three parameters were considered for tinnitus evaluation at 1-year follow-Lip: patient self-evaluation, visual analogue scale for intensity, and Tinnitus Handicap Inventory. Results: Tinnitus retraining therapy group improved at 1-year follow-up, considering the 3 parameters. The most important factor of failure to TRT efficacy has been the refuse to instrumentation when it was required, according to TRT recommendations. Tinnitus Handicap Inventory score in this group did not show any improvement (P = .009). Highest scores of tinnitus intensity (visual analogue scale) and handicap (Tinnitus Handicap Inventory) before treatment as well as the most disabled diagnosis (sudden deafness and Meniere's disease) had better response to TRT. Jastreboff's treatment categories, longer presence of tinnitus, existence of hyperacusis or hearing loss, type of prosthesis used, duration of the treatment, and index of assistance to our follow-up program were not related to the effectiveness of TRT. Conclusions: Tinnitus retraining therapy has demonstrated to be an effective treatment of tinnitus. More severe tinnitus are susceptible to get better response with this approach. Instrumentation, when recommended, is mandatory to obtain a higher relief of this symptom (EMB rating: B-2). (c) 2007 Elsevier Inc. All rights reserved. C1 Fdn HOsp Alcorcon, Unidad Otorrinolaringol, Madrid 28922, Spain. Inst ORL Antoli Candela, Unidad Acufenos, Madrid, Spain. Hosp Zarzuela, Dept Otorrinolaringol, Madrid, Spain. RP Herraiz, C (reprint author), Fdn HOsp Alcorcon, Unidad Otorrinolaringol, C Budapest,1, Madrid 28922, Spain. EM cherraizp@seorl.net CR Andersson G, 1997, PSYCHOTHER PSYCHOSOM, V66, P107 Bartnik G, 1999, P 6 INT TINN SEM 199, P415 Berry JA, 2002, ARCH OTOLARYNGOL, V128, P1153 FRACHET B, 1999, P 6 INT TINN SEM 199, P76 Hazell JWP, 1995, MECH TINNITUS, P57 HERRAIZ C, 2002, P 7 INT TINN SEM PER, P298 Herraiz C, 2005, OTOLARYNG HEAD NECK, V133, P774, DOI 10.1016/j.otohns.2005.07.006 Herrero-Vanrell R, 2001, ADV DRUG DELIVER REV, V52, P5, DOI 10.1016/S0169-409X(01)00200-9 JASTREBOFF PJ, 1993, BRIT J AUDIOL, V27, P7, DOI 10.3109/03005369309077884 JASTREBOFF PJ, 1990, NEUROSCI RES, V8, P221, DOI 10.1016/0168-0102(90)90031-9 Jastreboff P J, 2000, J Am Acad Audiol, V11, P162 Jastreboff PJ, 1996, AM J OTOL, V17, P236 LUXWELLENHOF G, 2002, P 7 INT TINN SEM PER, P277 Mc Kinney CJ, 1999, P 6 INT TINN SEM LON, P99 Newman CW, 1996, ARCH OTOLARYNGOL, V122, P143 SANCHEZ M, 2002, ACUFENOS ACTUALIZACI, P206 SANCHEZ TG, 2002, P 7 INT TINN SEM PER, P263 SHELDRAKE JB, 1995, P 5 INT TINN SEM 199, P531 VESTERAGER V, 1994, BRIT J AUDIOL, V28, P1, DOI 10.3109/03005369409077908 NR 19 TC 13 Z9 14 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0196-0709 J9 AM J OTOLARYNG JI Am. J. Otolaryngol. PD JUL-AUG PY 2007 VL 28 IS 4 BP 225 EP 229 DI 10.1016/j.amjoto.2006.09.004 PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA 189WV UT WOS:000248020200002 PM 17606035 ER PT J AU Suryadevara, AC Fattal, M Woods, CI AF Suryadevara, Amar C. Fattal, Michael Woods, Charles I. TI Nontraumatic cerebrospinal fluid rhinorrhea as a result of pseudotumor cerebri SO AMERICAN JOURNAL OF OTOLARYNGOLOGY LA English DT Article ID BENIGN INTRACRANIAL HYPERTENSION; TUMOR CEREBRI; TINNITUS AB Objective: The purpose of this study is to demonstrate that pseudotumor cerebri, also known as benign intracranial hypertension, can be an overlooked cause of spontaneous, nontraumatic cerebrospinal fluid (CSF) rhinorrhea. Study design and methods: This study presents a literature review and 2 case reports. The medical records of 2 patients who had nontraumatic CSF rhinorrhea were reviewed. Results: The patients were diagnosed as having spontaneous, nontraumatic CSF rhinorrhea, believed to have been caused by pseudotumor cerebri, and were surgically treated. The patients are obese, middle-aged women. Conclusions: Cerebrospinal fluid rhinorrhea is most often the result of trauma, but it may also occur spontaneously because of nontraumatic causes in some patients. Pseudotumor cerebri can be an overlooked cause of spontaneous, nontraumatic CSF rhinorrhea. A patient with signs and symptoms of pseudotumor cerebri should be evaluated and treated, if the condition is present, to prevent complications that include irreversible visual loss and CSF rhinorrhea. (c) 2007 Published by Elsevier Inc. C1 Upstate Med Univ, Dept Otolaryngol & Commun Sci, Syracuse, NY 13210 USA. RP Suryadevara, AC (reprint author), Upstate Med Univ, Dept Otolaryngol & Commun Sci, Reg Oncol Bldg,750 E Adams St, Syracuse, NY 13210 USA. 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J. Otolaryngol. PD JUL-AUG PY 2007 VL 28 IS 4 BP 242 EP 246 DI 10.1016/j.amjoto.2006.08.013 PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA 189WV UT WOS:000248020200006 PM 17606039 ER PT J AU Weng, SH Tang, JH Wang, GH Wang, XP Wang, H AF Weng, Shenhong Tang, Jihua Wang, Gaohua Wang, Xiaoping Wang, Hui TI Comparison of the addition of Siberian ginseng (Acanthopanax senticosus) versus fluoxetine to lithium for the treatment of bipolar disorder in adolescents: A randomized, double-blind trial SO CURRENT THERAPEUTIC RESEARCH-CLINICAL AND EXPERIMENTAL LA English DT Article DE Acanthopanax senticosus; bipolar disorder; adolescent; fluoxetine ID MANIA; CHILDREN; ANTIDEPRESSANT; DEPRESSION AB Background: Bipolar disorder (BD) is a common, recurrent, and often lifelong major psychiatric condition characterized by manic, depressive, and mixed episodes. Without treatment, there is substantial risk for morbidity and mortality, making BD a considerable public health problem. Objective: The purpose of this study was to compare the relative effectiveness and tolerability of Acanthopanax senticosus (A senticosus)-an herb that is derived from eleutherosides and polysaccharides found in the plant's root-versus fluoxetine added to lithium in the treatment of BD in adolescents. Methods: This was a double-blind, 6-week study. The patients were randomized into 2 treatment groups-A senticosus plus lithium (A senticosus group) and fluoxetine plus lithium (fluoxetine group). The patients underwent a baseline assessment using the 17-Item Hamilton Depression Rating Scale (HAMD-17) and the Young Mania Rating Scale (YMRS) during the screening period. Patients were scheduled for clinical visits at the end of weeks 1, 2, 4, and 6. At the end of the 6-week treatment period, each patient's condition was rated as follows: response (indicating an improvement of >= 50% in the HAMD-17 score from baseline); remission (a HAMD-17 score of <= 7); and switching to mania (a YMRS score >16, and meeting the criteria of the Diagnostic and Statistical Manual of Mental Disorders [Fourth Edition, Text Revision] for a manic episode). At each visit (with the exception of the enrollment visit), the patients were queried as to whether they experienced any health problems since the previous visit, a Treatment Emergent Symptom Scale assessment was completed, and the serum lithium concentration was analyzed. The patients were instructed to report adverse events (AEs) at any time during the study. AEs were also observed by the investigator(s) at clinical visits. Results: Seventy-nine Chinese adolescents were initially enrolled into the study. However, 76 adolescents were assessed for inclusion (45 females, 31 males; mean [SD] age, 15.4 [30.0] years; age range, 12-17 years) in the study. All included patients completed the study. After 6 weeks of treatment, the response rate between the A senticosus and the fluoxetine groups was similar (67.6% vs 71.8%, respectively). The remission rate between both groups was also similar (51.4% vs 48.7%). Analyzed by a general line model, the HAMD-17 scores revealed there was a significant time effect (F = 183.06; P < 0.01), but not a significant group effect (F = 0.99) or group-by-duration of treatment interaction (F = 0.779). Three patients in the fluoxetine group experienced switching to mania compared with no patient in the A senticosus group. AEs reported by patients in the A senticosus group were as follows: nausea, 2 (5.4%); rash, 1 (2.7%); and diarrhea, 1 (2.7%). AEs reported by patients in the fluoxetine group were as follows: nausea, 4 (10.3%); anxiety, 3 (7.7%); insomnia, 3 (7.7%); constipation, 1 (2.6%); and tinnitus, 1 (2.6%). Conclusion: Our study found no significant difference in these adolescents with BD treated with lithium plus adjunctive A senticosus or fluoxetine. All treatments were generally well tolerated. C1 Wuhan Univ, Basic Med Sch, Dept Pharmacol, Wuhan 430071, Peoples R China. Wuhan Univ, Renmin Hosp, Dept Psychiat, Wuhan 430072, Peoples R China. RP Wang, H (reprint author), Wuhan Univ, Basic Med Sch, Dept Pharmacol, Wuhan 430071, Peoples R China. 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TI Correlated neural activity as the driving force for functional changes in auditory cortex SO HEARING RESEARCH LA English DT Article; Proceedings Paper CT Conference on Auditory Cortex - Listening Brain CY SEP, 2006 CL Nottingham, ENGLAND SP MIC inst Hearing Res DE electrode arrays; spectro-temporal receptive field; coincidence detection; cat; plasticity ID CAT VISUAL-CORTEX; ENRICHED ACOUSTIC ENVIRONMENT; NEOCORTICAL PYRAMIDAL NEURONS; RECEPTIVE-FIELD PROPERTIES; INDUCED HEARING-LOSS; MONKEY MOTOR CORTEX; PRECISION GRIP TASK; VOICE ONSET TIME; CROSS-CORRELATION; NOISE TRAUMA AB The functional role of neural synchrony is reflected in cortical tonotopic map reorganization and in the emergence of pathological phenomena such as tinnitus. First of all experimenter-centered and subject-centered views of neural activity will be contrasted; this argues against the use of stimulus-correction procedures and favors the use of a correction procedure based on neural activity without reference to stimulus timing. Within a cortical column neurons fired synchronously with on average about 6 % of their spikes in a 1 ms bin and occasionally showing 30 % or more of such coincident spikes. For electrode separations exceeding 200 mu m the average peak correlation strength only occasionally reached 3 %. The experimental evidence for coincidence of neural activity, neural correlation and neural synchrony shows that horizontal fibers activity can induce strong neural correlations. Cortico- cortical connections for a large part connect cell groups with characteristic frequencies differing by more than one octave. Such neurons have generally non-overlapping receptive fields but still can have sizeable peak cross-correlations. 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Res. PD JUL PY 2007 VL 229 IS 1-2 BP 69 EP 80 DI 10.1016/j.heares.2007.01.008 PG 12 WC Audiology & Speech-Language Pathology; Neurosciences; Otorhinolaryngology SC Audiology & Speech-Language Pathology; Neurosciences & Neurology; Otorhinolaryngology GA 191PI UT WOS:000248143100008 PM 17296278 ER PT J AU Fujimotoa, K Nagashino, H Kinouchi, Y Danesh, AA Pandya, AS AF Fujimotoa, Ken'ichi Nagashino, Hirofumi Kinouchi, Yohsuke Danesh, Ali A. Pandya, Abhijit S. TI A plastic neural network model of sound therapy of tinnitus SO IEEJ TRANSACTIONS ON ELECTRICAL AND ELECTRONIC ENGINEERING LA English DT Article DE tinnitus; habituation; neural network model; plasticity; inhibition of oscillation; residual inhibition AB Tinnitus is the perception of phantom sounds. There are sound therapy techniques which have the clinical effect of making the sufferers temporarily stop perceiving tinnitus. To account for mechanisms of tinnitus generation and the clinical effect of sound therapy from the viewpoint of neural engineering, this paper describes a neural network model with a plastic coupling on the human auditory system. Through numerical simulations we observed an oscillatory state and a nonoscillatory state in the model; it was also noticed that the value of the plastic coupling changes through external stimulus, and subsequently the oscillation is inhibited. By associating the oscillatory state with the state of tinnitus generation, it could be explained that the habituated human auditory system temporarily stops perceiving tinnitus after sound therapy. (c) 2007 Institute of Electrical Engineers of Japan. Published by John Wiley & Sons, Inc. C1 Univ Tokushima, Sch Hlth Sci, Fac Med, Tokushima 7708509, Japan. Florida Atlantic Univ, Boca Raton, FL 33431 USA. RP Fujimotoa, K (reprint author), Univ Tokushima, Sch Hlth Sci, Fac Med, 3-18-15 Kuramoto Cho, Tokushima 7708509, Japan. EM fujimoto@medsci.tokushima-u.ac.jp CR Carpenter M. B., 1991, CORE TEXT NEUROANATO, V4th Hebb D. O., 1949, ORG BEHAV NEUROPSYCH Henry JA, 2006, J AM ACAD AUDIOL, V17, P104, DOI 10.3766/jaaa.17.2.4 LIEBLICH I, 1978, BIOL CYBERN, V28, P129, DOI 10.1007/BF00337134 Nagashima H., 1996, Neural Network World, V6 NR 5 TC 1 Z9 1 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 1931-4973 J9 IEEJ T ELECTR ELECTR JI IEEJ Trans. Electr. Electron. Eng. PD JUL PY 2007 VL 2 IS 4 BP 488 EP 490 DI 10.1002/tee.20198 PG 3 WC Engineering, Electrical & Electronic SC Engineering GA 191VE UT WOS:000248159300018 ER PT J AU Chen, YJ How, CK Chern, CH AF Chen, Y.-J. How, C.-K. Chern, C.-H. TI Cerebral dural arteriovenous fistulas presenting as pulsatile tinnitus SO INTERNAL MEDICINE JOURNAL LA English DT Editorial Material ID SINUS C1 Taipei Vet Gen Hosp, Emergency Dept, Taipei, Taiwan. Natl Yang Ming Univ, Dept Emergency Med, Taipei, Taiwan. RP Chen, YJ (reprint author), Taipei Vet Gen Hosp, Emergency Dept, Taipei, Taiwan. CR NISHIJIMA M, 1992, J NEUROSURG, V76, P600, DOI 10.3171/jns.1992.76.4.0600 Raupp S, 2004, EUR J NEUROL, V11, P489, DOI 10.1111/j.1468-1331.2004.00821.x Shah SB, 1999, LARYNGOSCOPE, V109, P54, DOI 10.1097/00005537-199901000-00012 Waldvogel D, 1998, J NEUROL, V245, P137, DOI 10.1007/s004150050193 NR 4 TC 3 Z9 4 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 1444-0903 J9 INTERN MED J JI Intern. Med. J. PD JUL PY 2007 VL 37 IS 7 BP 503 EP 503 DI 10.1111/j.1445-5994.2007.01375.x PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA 174DU UT WOS:000246922200013 PM 17547730 ER PT J AU McMaster, J Ng, T Dexter, M AF McMaster, Jacqueline Ng, Thomas Dexter, Mark TI Intraventricular rhabdoid meningioma SO JOURNAL OF CLINICAL NEUROSCIENCE LA English DT Article DE meningioma; rhabdoid; intraventricular; recurrence ID PAPILLARY MENINGIOMA; FEATURES; TUMOR AB Rhabdoid meningioma is a rare variant. of meningioma, often found in tumour recurrences. We report a 55-year-old woman with a history of intraventricular fibroblastic meningioma, who developed headache and tinnitus 5 years after complete resection of the initial tumour. Imaging confirmed a recurrent tumour in the intraventricular location. Histological analysis revealed rhabdoid meningioma. We reviewed the literature and were unable to find any previously reported cases of intraventricular rhabdoid meningioma. (c) 2006 Elsevier Ltd. All rights reserved. C1 Westmead Hosp, Dept Neurosurg, Wentwothville, NSW 2145, Australia. RP McMaster, J (reprint author), Westmead Hosp, Dept Neurosurg, POB 533, Wentwothville, NSW 2145, Australia. 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Clin. Neurosci. PD JUL PY 2007 VL 14 IS 7 BP 672 EP 675 DI 10.1016/j.jocn.2006.02.019 PG 4 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA 184QL UT WOS:000247656700013 PM 17433689 ER PT J AU Saunders, JC AF Saunders, James C. TI The role of central nervous system plasticity in tinnitus SO JOURNAL OF COMMUNICATION DISORDERS LA English DT Article; Proceedings Paper CT Annual Meeting of the American-Speech-Language-Hearing-Association CY NOV 16-19, 2006 CL Miami Beach, FL SP Amer Speech Language Hearing Assoc ID DORSAL COCHLEAR NUCLEUS; RAT INFERIOR COLLICULUS; HAIR-CELL STEREOCILIA; INDUCED HEARING-LOSS; EVOKED OTOACOUSTIC EMISSIONS; SPONTANEOUS NEURAL ACTIVITY; PRIMARY AUDITORY-CORTEX; INTENSE SOUND EXPOSURE; ACOUSTIC TRAUMA; MOLECULAR TREADMILL AB Tinnitus is a vexing disorder of hearing characterized by sound sensations originating in the head without any external stimulation. The specific etiology of these sensations is uncertain but frequently associated with hearing loss. The "neurophysiogical" model of tinnitus has enhanced appreciation of central nervous system (CNS) contributions. The model assumes that plastic changes in the primary and non-primary auditory pathways contribute to tinnitus with the former perhaps sustaining them, and the latter contributing to perceived severity and emotionality. These plastic changes are triggered by peripheral injury, which results in new patterns of brain activity due to anatomic alterations in the connectivity of CNS neurons. These alterations may change the balance between excitatory and inhibitory brain processes, perhaps producing cascades of new neural activity flowing between brainstem and cortex in a self-sustaining manner that produces persistent perceptions of tinnitus. The bases of this model are explored with an attempt to distinguish phenomenological from mechanistic explanations. Learning outcomes: (1) Readers will learn that the variables associated with the behavioral experience of tinnitus are as complex as the biological variables. (2) Readers will understand what the concept of neuroplastic brain change means, and how it is associated with tinnitus. (3) Readers will learn that there may be no one brain location associated with tinnitus, and it may result from interactions between multiple brain areas. (4) Readers will learn how disinhibition, spontaneous activity, neural synchronization, and tonotopic reorganization may contribute to tinnitus. (c) 2007 Elsevier Inc. All rights reserved. C1 Univ Penn, Dept Otorhinolaryngol Head & Neck Surg, Philadelphia, PA 19104 USA. RP Saunders, JC (reprint author), 3400 Spruce St, Philadelphia, PA 19104 USA. 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Commun. Disord. PD JUL-AUG PY 2007 VL 40 IS 4 BP 313 EP 334 DI 10.1016/j.jcoindis.2007.03.006 PG 22 WC Audiology & Speech-Language Pathology; Linguistics; Rehabilitation SC Audiology & Speech-Language Pathology; Linguistics; Rehabilitation GA 186GH UT WOS:000247766600006 PM 17418230 ER PT J AU Foster, CA Jabbour, P AF Foster, C. A. Jabbour, P. TI Barre'-Lieou syndrome and the problem of the obsolete eponym SO JOURNAL OF LARYNGOLOGY AND OTOLOGY LA English DT Article DE autonomic nervous system diseases; eponyms; spinal osteophytosis; vascular headaches; vertebrobasilar insufficiency; vestibulocochlear nerve diseases ID CEREBRAL-BLOOD-FLOW; HYPERTENSION AB Background: Eponym lists in major sources can give an aura of legitimacy to discredited diagnoses, as exemplified by the case of Barre-Lieou syndrome, a 'rare' vestibular disorder. Methods: A literature review for information on the posterior cervical syndrome of Barre-Lieou. Results: Barre-Lieou syndrome includes very common symptoms - tinnitus, dizziness, and head or neck pain - attributed to ischaemia caused by cervical sympathetic nerve compression. Its original description brings together many unrelated disorders, and its causative mechanism has been discredited. However, it appears credulously in a number of eponym lists, and references to the syndrome are steadily increasing on the internet in general and on alternative medicine and legal profession websites in particular. Conclusion: By inclusion in eponym lists, without a disclaimer, a syndrome can be given legitimacy before the general public. A syndrome, such as Barre-Lieou syndrome, that is useless to the medical profession can unfortunately prove to be very useful for litigants and disability claimants. C1 Univ Colorado, Hlth Sci Ctr, Dept Otorhinolaryngol Head & Neck Surg, Aurora, CO 80045 USA. Univ Colorado, Hlth Sci Ctr, Dept Neurosurg, Denver, CO USA. RP Foster, CA (reprint author), Univ Colorado, Hlth Sci Ctr, Dept Otorhinolaryngol Head & Neck Surg, POB 6510,Mail Stop F736, Aurora, CO 80045 USA. 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Otol. PD JUL PY 2007 VL 121 IS 7 BP 680 EP 683 DI 10.1017/S002221510600346X PG 4 WC Otorhinolaryngology SC Otorhinolaryngology GA 224YU UT WOS:000250485100014 PM 17052362 ER PT J AU Cave, KM Cornish, EM Chandler, DW AF Cave, Kara M. Cornish, Elizabeth M. Chandler, David W. TI Blast injury of the ear: Clinical update from the global war on terror SO MILITARY MEDICINE LA English DT Article ID HEARING AB The purpose of this study was to describe the effects of blast exposure on hearing status. This study retrospectively analyzed hearing thresholds and otologic complaints for >250 patients with blast-related injuries from the global war on terror. Of patients who received full diagnostic evaluations, 32% reported a history of tympanic membrane perforation, 49% experienced tinnitus, 26% reported otalgia (ear pain), and 15% reported dizziness. Expected hearing thresholds were computed by applying age-correction factors to hearing tests performed earlier in the service members' careers and before their most recent deployment. Expected hearing thresholds were significantly better than actual postdeployment thresholds, indicating that significant changes occurred in the patients' hearing that could not be accounted for by age. Results from this study underline the need for documentation of pre-and postdeployment hearing tests and prompt otologic evaluation for the blast-exposed population. C1 USA, Ballist Res Lab, Human Res & Engn Directorate, Aberdeen Proving Ground, MD 21005 USA. Madigan Army Med Ctr, Dept Audiol, Tacoma, WA 98431 USA. Off Surg Gen, Falls Church, VA 22041 USA. RP Cave, KM (reprint author), USA, Ballist Res Lab, Human Res & Engn Directorate, Aberdeen Proving Ground, MD 21005 USA. 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PD JUL PY 2007 VL 172 IS 7 BP 726 EP 730 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA 189SZ UT WOS:000248010100011 PM 17691685 ER PT J AU Mota, LAA Melo, MSI Santos, MHP De Albuquerque, KMG Tavares, CD AF Alves Mota, Luiz Alberto Iglesias Melo, Marilia Silvino Pedrosa Santos, Maria Heloisa Gomes De Albuquerque, Katia Maria Tavares, Cristiana De Lima TI Cisplatin ototoxicity: Series of cases SO REVISTA DA ASSOCIACAO MEDICA BRASILEIRA LA Portuguese DT Article DE audiometry; hearing; cisplatin ID CHILDREN; AGENTS; SYSTEM AB OBJECTIVE. To evaluate the clinic and audiometric evolution of individuals who underwent chemotherapy with cisplatin. METHODS. Four volunteers, all women, between 38 and 69 years of age were descriptively evaluated. All did otorinolaryngoiatric exam and audiometric evaluation with tonal and speech audiometric and impedance tests before and after treatment with cisplatin. In addition, all were subjectively evaluated pre- and post-chemotherapy by a questionnaire. RESULTS. One volunteer did not present auditory disorders. Three volunteers presented bilateral hearing loss, mild to moderate in 6kHz and 8kHz frequencies, after chemotherapy with cisplatin. All volunteers who developed hearing loss after treatment also presented tinnitus. CONCLUSION. Since cisplatin is considered ototoxic all individuals undergoing chemotherapy with this drug must be submitted to audiometric monitoring for early diagnosis of a hearing loss. RP Mota, LAA (reprint author), Rua Venezuela 182, BR-52020170 Espinheiro Recife, PE, Brazil. 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Bras. Otorrinolaringol., V69, P222, DOI 10.1590/S0034-72992003000200012 NR 24 TC 0 Z9 0 PU ASSOC MEDICA BRASILEIRA PI SAO PAULO PA RUA SAO CARLOS DO PINHAL 324, CAIXA POSTAL 8904, SAO PAULO, SP, BRAZIL SN 0104-4230 J9 REV ASSOC MED BRAS JI Rev. Assoc. Med. Bras. PD JUL-AUG PY 2007 VL 53 IS 4 BP 370 EP 373 DI 10.1590/S0104-42302007000400026 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA 281ZZ UT WOS:000254538700025 PM 17823744 ER PT J AU Quaranta, N Baguley, DM Moffat, DA AF Quaranta, Nicola Baguley, David M. Moffat, David A. TI Change in hearing and tinnitus in conservatively managed vestibular schwannomas SO SKULL BASE-AN INTERDISCIPLINARY APPROACH LA English DT Article; Proceedings Paper CT 4th International Conference on Vestibular Schwannoma and Other Cerebellopontine Angle Lesions CY JUL 14-17, 2003 CL CAMBRIDGE, ENGLAND DE vestibular schwannoma; conservative management; hearing preservation ID ACOUSTIC NEUROMAS; RETROSIGMOID APPROACH; TUMOR-GROWTH; PRESERVATION; SURGERY; RISK AB Objective: The aim of this study was to evaluate the change of hearing and tinnitus in a group of conservatively managed unilateral vestibular schwannomas (VS). Design: Retrospective case series review. Setting: Tertiary referral otoneurological and skull base surgery department. Participants: Seventy patients affected by unilateral VS with at least two audiograms available were retrospectively evaluated. Main outcome measures: Changes in pure tone average (PTA), speech discrimination score (SDS), and tinnitus were analyzed. Results: At diagnosis 16 patients (22.9%) had a PTA of 0 to 30 dB and 38 (54.4%) a PTA of 0 to 50 dB. At the end of the follow-up period, 9 patients (12.9%) had a PTA of 0 to 30 dB and 27 (38.7%) had a PTA of 0 to 50 dB, representing a hearing preservation rate of 56% and 70%, respectively. Of patients with both tonal and speech audiometry, 71.4% with class A hearing (PTA < 30 dB/SDS > 70%) maintained their initial hearing and 60% with class A or B hearing (PTA < 50 dB/SDS > 50%) maintained this useful hearing. Forty-two patients (60%) did not show a significant growth in their tumor over the period of observation. In this group of patients the mean PTA after a mean follow-up time of 40 months decreased from 44 dB HL to 50.8 dB HL, with a yearly rate of 2.47 dB HL. The chance of maintaining a PTA of 0 to 30 dB in this group of patients was 57.1% and a PTA of 0 to 50 dB was 81.4%. Conclusions: In this group of patients affected by VS and managed conservatively with a mean follow-up of 33.3 months, the risk of losing eligibility for hearing preservation surgery was lower than 30%. C1 Univ Bari, Dept Ophthalmol & Otolaryngol, Otolaryngol Clin G Lugli, Bari, Italy. Addenbrookes Cambridge Univ Hosp, Dept Otoneurol & Skull Base Surg, Cambridge, England. RP Quaranta, N (reprint author), Policlin Bari, Clin ORL G Lugli, I-70124 Bari, Italy. EM nicola.quaranta@orl.uniba.it CR [Anonymous], 1995, OTOLARYNGOL HEAD NEC, V113, P179 Boothroyd A, 1968, SOUND, V2, P3 Charabi S, 2000, LARYNGOSCOPE, V110, P1720, DOI 10.1097/00005537-200010000-00030 Friedman RA, 2001, OTOLARYNG HEAD NECK, V125, P544, DOI 10.1067/mhn.2001.119675 Fucci MJ, 1999, AM J OTOL, V20, P495 Graamans K, 2003, ACTA OTO-LARYNGOL, V123, P51, DOI 10.1080/0036554021000028075 Hoistad DL, 2001, OTOL NEUROTOL, V22, P682, DOI 10.1097/00129492-200109000-00021 Kobayashi T, 1996, ACTA OTO-LARYNGOL, V116, P791, DOI 10.3109/00016489609137927 KVETON JF, 1990, LARYNGOSCOPE, V100, P473 Magnan J, 2002, OTOL NEUROTOL, V23, P141, DOI 10.1097/00129492-200203000-00006 Massick DD, 2000, LARYNGOSCOPE, V110, P1843, DOI 10.1097/00005537-200011000-00015 Moffat DA, 1999, OTOLARYNG HEAD NECK, V121, P781, DOI 10.1053/hn.1999.v121.a91263 Moffat DA, 1998, AM J OTOL, V19, P82 PRASHER DK, 1995, ACTA OTO-LARYNGOL, V115, P375, DOI 10.3109/00016489509139332 Rosenberg SI, 2000, LARYNGOSCOPE, V110, P497, DOI 10.1097/00005537-200004000-00002 Satar B, 2002, LARYNGOSCOPE, V112, P1500, DOI 10.1097/00005537-200208000-00031 Stipkovits EM, 2001, EUR ARCH OTO-RHINO-L, V258, P467, DOI 10.1007/s004050100369 Tos M, 1999, LARYNGOSCOPE, V109, P736, DOI 10.1097/00005537-199905000-00011 Tschudi DC, 2000, AM J OTOL, V21, P722 Walsh RM, 2000, CLIN OTOLARYNGOL, V25, P28, DOI 10.1046/j.1365-2273.2000.00317.x Warrick P, 1999, AM J OTOL, V20, P758 NR 21 TC 3 Z9 3 PU THIEME MEDICAL PUBL INC PI NEW YORK PA 333 SEVENTH AVE, NEW YORK, NY 10001 USA SN 1531-5010 J9 SKULL BASE-INTERD AP JI Skull Base-Interdiscip. Appr. PD JUL PY 2007 VL 17 IS 4 BP 223 EP 228 DI 10.1055/s-2007-984491 PG 6 WC Clinical Neurology; Otorhinolaryngology; Surgery SC Neurosciences & Neurology; Otorhinolaryngology; Surgery GA 198XB UT WOS:000248659700001 PM 18174921 ER PT J AU Bovo, R Ortore, R Ciorba, A Berto, A Martini, A AF Bovo, Roberto Ortore, Rocco Ciorba, Andrea Berto, Anna Martini, Alessandro TI Bilateral sudden profound hearing loss and vertigo as a unique manifestation of bilateral symmetric inferior pontine infarctions SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE bilateral sudden hearing loss; cochlear nucleus infarction; pontine infarction; sudden hearing loss; vertigo; vestibular nucleus infarction ID BASILAR ARTERY-OCCLUSION; VERTEBROBASILAR INSUFFICIENCY; DEAFNESS AB Objectives: We present a case of sudden bilateral profound deafness and vertigo, without any accompanying neurologic signs, secondary to bilateral infarctions of the cochlear and vestibular nuclei. Methods: Vertigo, vomiting, tinnitus, and bilateral profound deafness suddenly developed in a 65-year-old woman without any accompanying neurologic signs. In particular, she did not present dysarthria, numbness, cranial nerve palsies, or visual or cerebellar signs. Results: Magnetic resonance imaging of the brain revealed 2 fresh infarctions of 8 to 10 rum symmetrically localized in the posterolateral bulbopontine junction. Angiography revealed a complete occlusion of the basilar artery, with a well-represented backward flow of its distal portion from the carotid artery via posterior communicating arteries. Excluding a transient ischemic attack that occurred 16 days after the acute episode, the patient had had no other neurologic events at 8 months of follow-up. Conclusions: Acute vertigo and sudden deafness in a patient with known cerebrovascular occlusive disease may represent the warning signs of an impending brain stem or cerebellar infarction, even when other neurologic signs are absent. These events are fortunately very rare, but should be considered by clinicians who see patients with vertigo. C1 Univ Ferrara, Dept Audiol, I-44100 Ferrara, Italy. RP Bovo, R (reprint author), Arcispedle S Anna, Dept Audiol, Corso Giovecca 203, I-44100 Ferrara, Italy. CR BOGOUSSLAVSKY J, 1991, NEUROLOGY, V41, P855 Deplanque D, 1998, J NEUROL NEUROSUR PS, V64, P817 Fetterman BL, 1996, LARYNGOSCOPE, V106, P1347, DOI 10.1097/00005537-199611000-00008 Huang CC, 2005, EUR ARCH OTO-RHINO-L, V262, P576, DOI 10.1007/s00405-004-0874-1 HUANG MH, 1993, STROKE, V24, P132 Ichikawa H, 1994, Rinsho Shinkeigaku, V34, P569 Lee H, 2005, J NEUROL SCI, V228, P99, DOI 10.1016/j.jns.2004.10.016 Lee H, 2003, J NEUROL NEUROSUR PS, V74, P539, DOI 10.1136/jnnp.74.4.539 LEHNHARDT E, 1991, HNO, V39, P378 Schmiz A, 2000, LARYNGO RHINO OTOL, V79, P253 Sunose H, 2000, OTOLARYNG HEAD NECK, V122, P146, DOI 10.1016/S0194-5998(00)70165-3 Toyoda K, 2002, J NEUROL SCI, V193, P147, DOI 10.1016/S0022-510X(01)00663-3 Welsh LW, 2003, ANN OTO RHINOL LARYN, V112, P657 NR 13 TC 5 Z9 5 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD JUN PY 2007 VL 116 IS 6 BP 407 EP 410 PG 4 WC Otorhinolaryngology SC Otorhinolaryngology GA 181NW UT WOS:000247444400003 PM 17672241 ER PT J AU Hatipoglu, HG Durakoglugil, T Ciliz, D Yuksel, E AF Hatipoglu, Hatice Guel Durakoglugil, Tugba Ciliz, Deniz Yueksel, Enis TI Comparison of FSE T2W and 3D FIESTA sequences in the evaluation of posterior fossa cranial nerves with MR cisternography SO DIAGNOSTIC AND INTERVENTIONAL RADIOLOGY LA English DT Article DE magnetic resonance imaging; cranial nerves; cisternography ID 3-DIMENSIONAL CONSTRUCTIVE INTERFERENCE; STEADY-STATE; VISUALIZATION; ECHO AB PURPOSE The aim of this study was to compare 3D fast imaging with steady state acquisition (3D FIESTA) to fast spin echo T2-weighted (FSE T2W) MRI sequences in the imaging of cisternal parts of cranial nerves V-XII. MATERIALS AND METHODS We retrospectively evaluated the temporal MRI sequences of 50 patients (F:M ratio, 27:23; mean age, 44.5 +/- 15.9 years) who were admitted to our hospital with vertigo, tinnitus and hearing loss. In all, we evaluated 800 nerves. Two radiologists, working independently, divided the imaging findings into 3 groups: 0 (not visualized), 1 (partially visualized), and 2 (completely visualized). RESULTS The rate of visualization of these cranial nerves with FSE T2W and 3D FIESTA sequences, respectively, (partially and completely visualized) were as follows: nerve V (100% and 100%); nerve VI (43% and 98%); nerve VII (100% and 100%); nerve VIII (100% and 100%); nerve IX-XI complex (67% and 100%); nerve XII (2% and 91%). CONCLUSION 3D FIESTA sequences are superior to FSE T2W sequences in the imaging of cisternal parts of the posterior fossa nerves. 3D FIESTA sequences may be used for obtaining high-resolution MR cisternography images. RP Hatipoglu, HG (reprint author), Ankara Numune Training & Res Hosp, Dept Radiol, Ankara, Turkey. 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Interv. Radiol. PD JUN PY 2007 VL 13 IS 2 BP 56 EP 60 PG 5 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA 279GJ UT WOS:000254343000002 PM 17562507 ER PT J AU Plant, K Holden, L Skinner, M Arcaroli, J Whitford, L Law, MA Nel, E AF Plant, Kerrie Holden, Laura Skinner, Margo Arcaroli, Jennifer Whitford, Lesley Law, Mary-Ann Nel, Esti TI Clinical evaluation of higher stimulation rates in the nucleus research platform 8 system SO EAR AND HEARING LA English DT Article ID COCHLEAR IMPLANT SYSTEM; SPEECH CODING STRATEGY; ELECTRICAL-STIMULATION; RECOGNITION; PERCEPTION; THRESHOLD; ACE AB Objective. The effect on speech perception of using higher stimulation rates than the 14.4 kHz available in the Nucleus 24 cochlear implant system was investigated. The study used the Nucleus Research Platform 8 (RP8) system, comprising the CI24RE receiver-stimulator with the Contour electrode array, the L34SP body-worn research speech processor, and the Nucleus Programming Environment (NPE) fitting and Neural Response Telemetry (NRT) software. This system enabled clinical investigation of higher stimulation rates before an implementation in the Freedom cochlear implant system commercially released by Cochlear Limited. Design: Use of higher stimulation rates in the ACE coding strategy was assessed in 15 adult subjects. An ABAB experimental design was used to control for order effects. Program A used a total stimulation rate of between 12 kHz and 14.4 kHz. This program was used for at least the first 3 mo after initial device activation. After evaluation with this program, each subject was provided with two different higher stimulation rate programs: one with a total stimulation rate of 24 kHz and the other with a total stimulation rate of 32 kHz. After a 6-week period of familiarization, each subject identified his/her preferred higher rate program (program B), and this was used for the evaluation. Subjects then repeated their use of program A for 3 wk, then program B for 3 wk, before the second evaluation with each. Speech perception was evaluated by using CNC open-set monosyllabic words presented in quiet and CUNY open-set sentences presented in noise. Preference for stimulation rate program was assessed via a subjective questionnaire. Threshold (T)- and Comfortable (C)-levels, as well as subjective reports of tinnitus, were monitored for each subject throughout the study to determine whether there were any changes that might be associated with the use of higher stimulation rates. Results: No significant mean differences in speech perception results were found for the group between the two programs for tests in either quiet or noise. Analysis of individual subject data showed that five subjects had significant benefit from use of program B for tests administered in quiet and for tests administered in noise. However, only two of these subjects showed benefit in both test conditions. One subject showed significant benefit from use of program A when tested in quiet, whereas another showed benefit with this program in noise. Each subject's preferred program varied. Five subjects reported a preference for program A, eight subjects reported a preference for program B and two reported no overall preference. Preference between the different stimulation rates provided within program B also varied, with 10 subjects preferring 24 kHz and five preferring 32 kHz total stimulation rates. A significant increase in T-levels from baseline measures was observed after three weeks of initial experience with program B, however there was no difference between the baseline levels and those obtained after five weeks of use. No significant change in C-levels was found over the monitoring period. No long-term changes in tinnitus that could be associated with the use of the higher stimulation rates were reported by any of the subjects. Conclusions: The use of higher stimulation rates may provide benefit to some but not all cochlear implant recipients. It is important to optimize the stimulation rate for an individual to ensure maximal benefit. The absence of any changes in T- and C-levels or in tinnitus suggests that higher stimulation rates are safe for clinical use. C1 Cooperat Res Ctr Cochlear Implant & Hearing Aid I, Melbourne, Vic, Australia. Washington Univ, Sch Med, St Louis, MO USA. Cochlear Corp, Denver, CO USA. Cochlear Ltd, Melbourne, Vic 3002, Australia. RP Plant, K (reprint author), Cochlear Ltd, Level 1,174 Victoria Parade, Melbourne, Vic 3002, Australia. 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PD JUN PY 2007 VL 28 IS 3 BP 381 EP 393 DI 10.1097/AUD.0b013e31804793ac PG 13 WC Audiology & Speech-Language Pathology; Otorhinolaryngology SC Audiology & Speech-Language Pathology; Otorhinolaryngology GA 166TP UT WOS:000246403600011 PM 17485987 ER PT J AU Zheng, Y Baek, JH Smith, PF Darlington, CL AF Zheng, Yiwen Baek, Jean-Ha Smith, Paul F. Darlington, Cynthia L. TI Cannabinoid receptor down-regulation in the ventral cochlear nucleus in a salicylate model of tinnitus SO HEARING RESEARCH LA English DT Article DE tinnitus; cochlear nucleus; salicylate; cannabinoid receptors; rat ID UNILATERAL VESTIBULAR DEAFFERENTATION; LOCALIZATION; ACTIVATION; SYSTEM; BRAIN; RATS AB Cannabinoid CB1 receptors have not been systematically investigated in the brainstem cochlear nucleus, nor have they been investigated in relation to tinnitus. Using immunohistochemistry and cell counting, we showed that a large number of neurons in the rat cochlear nucleus possess cannabinoid CB1 receptors. Following salicylate injections that induced the behavioural manifestations of tinnitus, the number of principal neurons in the ventral cochlear nucleus expressing CB1 receptors significantly decreased, while the number of CB1-positive principal neurons in the dorsal cochlear nucleus did not change significantly. These results suggest that CB I receptors in the cochlear nucleus may be important for auditory function and that a down-regulation of CB I receptors in the ventral cochlear nucleus may be related to the development of tinnitus. (c) 2007 Elsevier B.V. All rights reserved. C1 Univ Otago, Dept Pharmacol & Toxicol, Sch Med Sci, Dunedin, New Zealand. RP Smith, PF (reprint author), Univ Otago, Dept Pharmacol & Toxicol, Sch Med Sci, POB 913, Dunedin, New Zealand. 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J., 1991, STAT PRINCIPLES EXPT Zhang R, 2005, BRAIN RES, V1037, P107, DOI 10.1016/j.brainres.2005.01.018 NR 23 TC 17 Z9 17 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-5955 J9 HEARING RES JI Hear. Res. PD JUN PY 2007 VL 228 IS 1-2 BP 105 EP 111 DI 10.1016/j.heares.2007.01.028 PG 7 WC Audiology & Speech-Language Pathology; Neurosciences; Otorhinolaryngology SC Audiology & Speech-Language Pathology; Neurosciences & Neurology; Otorhinolaryngology GA 174QP UT WOS:000246957900011 PM 17376618 ER PT J AU Brozoski, TJ Ciobanu, L Bauer, CA AF Brozoski, Thomas J. Ciobanu, Luisa Bauer, Carol A. TI Central neural activity in rats with tinnitus evaluated with manganese-enhanced magnetic resonance imaging (MEMRI) SO HEARING RESEARCH LA English DT Article DE tinnitus; CNS activity; MEMRI; animal model; plasticity ID DORSAL COCHLEAR NUCLEUS; INFERIOR COLLICULUS; AUDITORY-CORTEX; INDUCE TINNITUS; INTENSE SOUND; SINGLE UNITS; ANIMAL-MODEL; GUINEA-PIG; CAT; MANIPULATIONS AB The pathophysiology of tinnitus, the perception of sound in the absence of acoustic stimulation, is largely unknown, although several lines of research implicate long-term neuroplastic loss of inhibition. The evidence to date suggests that the neuroplastic alterations are likely to be found in multiple brain structures. The present study used manganese-enhanced magnetic resonance imaging (MEMRI) to assess the pattern of neural activity in the central auditory pathway of rats with psychophysical evidence of chronic acoustic-exposure-induced tinnitus. Manganese, an activity-dependent paramagnetic contrast agent, accumulates in active neurons through voltage-gated calcium channels, primarily at synapses, and serves as both a structural and functional indicator. Comparison images were obtained from normal subjects exposed to external tinnitus-like sound, and from tinnitus subjects treated with vigabatrin, a GABA agonist shown to eliminate the psychophysical evidence of tinnitus in rats. MEMRI indicated: (1) In rats with evidence of tinnitus, activity was generally elevated in the auditory brainstem, with significant elevation in the cerebellar parallocculus, the posterior ventral cochlear nucleus, and the inferior colliculus; in general forebrain structures showed decreased activity, although MEMRI may be a less sensitive indicator of forebrain activity than brainstem activity; (2) in normal rats exposed to a tinnitus-like sound, a similar pattern of elevated brainstem activity and decreased forebrain activity was evident, with the notable exception of the paraflocculus, where artificial tinnitus had no effect and (3) vigabatrin, decreased brainstem activity to control levels, in rats with prior evidence of tinnitus, and decreased forebrain activity to below control levels. It was concluded that chronic tinnitus in rats is associated with focal activity elevation in the auditory brainstem and increased activity in the paraflocculus that may be unique to tinnitus. (c) 2007 Published by Elsevier B.V. C1 So Illinois Univ, SOM, Div Otolaryngol, Springfield, IL 62794 USA. Univ Illinois, Beckman Inst Adv Sci & Technol, Biomed Imaging Ctr, Urbana, IL 61801 USA. RP Brozoski, TJ (reprint author), So Illinois Univ, SOM, Div Otolaryngol, 801 N Rutledge St,Rm 3205,POB 19629, Springfield, IL 62794 USA. 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Res. PD JUN PY 2007 VL 228 IS 1-2 BP 168 EP 179 DI 10.1016/j.heares.2007.02.003 PG 12 WC Audiology & Speech-Language Pathology; Neurosciences; Otorhinolaryngology SC Audiology & Speech-Language Pathology; Neurosciences & Neurology; Otorhinolaryngology GA 174QP UT WOS:000246957900017 PM 17382501 ER PT J AU Laskawi, R AF Laskawi, R. TI Botulinum toxin treatment in the head and neck region SO HNO LA German DT Article DE Botulinumtoxin-Therapie; Kopf-Hals-Bereich; Neue Entwicklungen; Botulinum toxin treatment; Head and neck region; New developments ID THERAPEUTIC-USE; DISTURBANCES; MUSCULATURE; INJECTIONS; TINNITUS; SYMPTOMS; RHINITIS; THROAT; NOSE AB Some interesting developments, aspects, and problems concerning botulinum toxin treatment of disorders of the head and neck region have recently been reported. These new approaches are discussed in this review. They include applications into mimic muscles (prevention of scar formation, treatment of depressions), into laryngeal muscles, and into the upper esophagus. In addition, treatment of different forms of headache and tinnitus as well as applications in the autonomic nervous system are addressed. Some of these options will shortly be put into clinical use, while others have to be checked further in clinical studies. C1 Univ HNO Klin, D-37075 Gottingen, Germany. RP Laskawi, R (reprint author), Univ HNO Klin, Robert Koch Str 40, D-37075 Gottingen, Germany. 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Previous functional imaging studies have focused primarily on the cortical centers. However, none of these examined the functional nature of associated white matter interconnecting these cortical centers. In this study, we investigate the integrity of white matter tracts interconnecting the auditory system to the parietal and frontal corticies in tinnitus patients using diffusion tensor imaging. Our preliminary results suggest the possible involvement of associated white matter structures in addition to processing cortical centers in tinnitus patients compared with healthy subjects. (c) 2006 Elsevier Ltd. All rights reserved. C1 Kyungpook Natl Univ, Dept Med & Biol Engn, Taegu, South Korea. Kyungpook Natl Univ, Coll Med, Dept Otolaryngol, Taegu, South Korea. Kyungpook Natl Univ, Coll Med, Dept Diagnost Radiol, Taegu, South Korea. Keimyung Univ, Coll Med, Dongsan Med Ctr, Dept Radiol, Taegu, South Korea. RP Chang, YM (reprint author), Kyungpook Natl Univ Hosp, Dept Radiol, 50 Samduk Dong 2Ga, Taegu 700721, South Korea. 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Clin. Neurosci. PD JUN PY 2007 VL 14 IS 6 BP 515 EP 519 DI 10.1016/j.jocn.2006.10.002 PG 5 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA 167ZA UT WOS:000246490200002 PM 17368031 ER PT J AU Esposti, DD Cosentino, ER Santi, F De Sanctis, D Dormi, A Bacchelli, S Enonguene, JS Brandolini, C Modugno, GC Prandin, MG Rinaldi, ER Ambrosioni, E Pirodda, A Borghi, C AF Esposti, D. Degli Cosentino, E. R. Santi, F. De Sanctis, D. Dormi, A. Bacchelli, S. Enonguene, J. S. Brandolini, C. Modugno, G. C. Prandin, M. G. Rinaldi, E. R. Ambrosioni, E. Pirodda, A. Borghi, C. TI Tinnitus and blood pressure values in heart failure patients SO JOURNAL OF HYPERTENSION LA English DT Meeting Abstract CT 17th European Meeting on Hypertension CY JUN 15-19, 2007 CL Milan, ITALY SP Boehringer Ingelheim, Daiichi-Sankyo, NOVARTIS, SERVIER, Bayer Healthcar AG, Brystol-Myer Squibb, Merck-Sharp & Dohme, PRIZER Inc, Procter& Gamble Pharmaceut C1 Univ Bologna, S Orsola Hosp, Bologna, Italy. Univ Bologna, Bologna, Italy. NR 0 TC 0 Z9 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0263-6352 J9 J HYPERTENS JI J. Hypertens. PD JUN PY 2007 VL 25 SU 2 BP S171 EP S171 PG 1 WC Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 195EK UT WOS:000248395100594 ER PT J AU Abram, S Rosenblatt, P Holcomb, S AF Abram, Steven Rosenblatt, Paul Holcomb, Stephen TI Stereotactic radiation techniques in the treatment of acoustic schwannomas SO OTOLARYNGOLOGIC CLINICS OF NORTH AMERICA LA English DT Article ID VESTIBULAR SCHWANNOMA; HEARING PRESERVATION; NEUROMA RADIOSURGERY; SINGLE-INSTITUTION; RADIOTHERAPY; MANAGEMENT; EXPERIENCE; MICROSURGERY; TYPE-2 AB Medical decision-making is based on benefit-to-cost analysis. Optimally, treatment obtains a high degree of benefit while minimizing the physical, social, and financial costs. The goals of the treatment of acoustic schwannomas are prohibiting tumor growth and alleviation of symptoms caused by damage to local structures. These symptoms-tinnitus, ataxia, and hearing loss-secondary to eighth nerve dysfunction, as well as symptoms arising from damage to adjacent structures such as the facial nerve, trigeminal nerve, or pons, can be caused by tumor growth or treatment. Determination of optimal therapy must also take into account an understanding of the natural history of the disease, because acoustic schwannomas are slow-growing benign tumors that when left untreated, usually enlarge over time and cause problems. C1 St Thomas Hosp, Inst Neurosci, Nashville, TN 37205 USA. RP Abram, S (reprint author), St Thomas Hosp, Inst Neurosci, 4220 Harding Rd, Nashville, TN 37205 USA. 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Clin. N. Am. PD JUN PY 2007 VL 40 IS 3 BP 571 EP + DI 10.1016/j.otc.2007.04.001 PG 19 WC Otorhinolaryngology SC Otorhinolaryngology GA 184ZS UT WOS:000247681700009 PM 17544696 ER PT J AU Klingmann, C Praetorius, M Baumann, I Plinkert, PK AF Klingmann, Christoph Praetorius, Mark Baumann, Ingo Plinkert, Peter K. TI Barotrauma and decompression illness of the inner ear: 46 cases during treatment and follow-up SO OTOLOGY & NEUROTOLOGY LA English DT Article DE diving accidents; eustachian tube dysfunction; hearing loss; inner ear barotrauma; inner ear decompression illness; long-term follow-up; hyperbaric oxygen therapy ID TO-LEFT SHUNT; PATENT FORAMEN OVALE; SICKNESS; DIVERS; RISK AB Introduction: Diving accidents affecting the inner ear are much more common than was once thought. Among the 319 patients treated in our clinic between January 2002 and November 2005, 46 cases involved 44 divers with symptoms of acute inner ear disorders. The objective of the present article is to investigate the symptoms of the acute disorders and assess any residual damage. Study Design: Retrospective case analysis. Materials and Methods: The medical records were used to study the cases of 18 divers treated for inner ear decompression illness on 20 occasions and 26 divers who had inner ear barotrauma. The symptoms of the disorder at the beginning of treatment, latency period before the first therapeutic measures, kind of initial therapy, symptoms after the accident, and hearing and balance functions at the last examination in our clinic were assessed. Divers with inner ear decompression illness were examined via means of transcranial or carotid Doppler ultrasonography for the presence of a vascular right-to-left (R/L) shunt. Results: Of 18 divers with inner ear decompression illness, 17 reported vertigo as the main symptom. In one diver, the inner ear decompression illness was manifested bilaterally. The divers with inner ear decompression illness had been treated with hyperbaric oxygen therapy in 14 of 20 cases; the average latency period before the start of therapy was 40 hours (median, 10 h). In 15 (83%) of 18 patients, a large R/L shunt was detected, and in 14 (78%) of 18 patients, residual cochleovestibular damage was detected. Only 9 of 26 patients with inner ear barotrauma mentioned feeling dizzy, and in no patient was vertigo the main symptom. Twenty-one patients complained of tinnitus, whereas 20 complained of hearing loss. The hearing loss ranged from an unobtrusive difference of 10 dB between the ears up to complete deafness. Three patients were subjected to tympanoscopy because of suspected rupture of the round window membrane. Of patients with inner ear barotrauma, 78% had residual cochleovestibular damage. Conclusion: We describe for the first time a patient with bilateral manifestation of inner ear decompression illness. Inner ear decompression illness is frequently associated with a R/L shunt; therefore, after a diving accident, the patient's fitness to dive should be assessed via a specialist in diving medicine. Both decompression illness and barotrauma of the inner ear result in residual cochleovestibular damage in more than three of four patients. C1 Univ Heidelberg, Dept Otolaryngol Head & Neck Surg, D-69120 Heidelberg, Germany. RP Klingmann, C (reprint author), Univ Heidelberg, Dept Otolaryngol Head & Neck Surg, Neuenheimer Feld 400, D-69120 Heidelberg, Germany. EM christoph_klingmann@med.uni-heidelberg.de CR ALMELING M, 1999, HDB TAUCH HYPERBARME, P1 Bove AA, 1998, UNDERSEA HYPERBAR M, V25, P175 Cantais E, 2003, CRIT CARE MED, V31, P84, DOI 10.1097/01.CCM.0000038040.42972.81 FARMER JC, 1976, LARYNGOSCOPE, V86, P1315, DOI 10.1288/00005537-197609000-00003 Klingmann C, 2003, LARYNGOSCOPE, V113, P1356, DOI 10.1097/00005537-200308000-00017 Klingmann C, 2002, ARCH OTOLARYNGOL, V128, P586 Klingmann C, 2004, LARYNGOSCOPE, V114, P2048, DOI 10.1097/.01.mlg.0000147947.43547.e9 Klingmann C, 2004, HNO, V52, P757, DOI 10.1007/s00106-004-1105-1 Klingmann C, 2004, HNO, V52, P891, DOI 10.1007/s00106-003-1025-5 MATHIEU D, 2005, EUR J UNDERW HYPERB, V6, P23 Molvaer O I, 1979, Acta Otolaryngol Suppl, V360, P187 Moon R, 1991, UNDERSEA BIOMED RES, V13, P15 Nachum Z, 2001, J PHARMACOL EXP THER, V296, P121 Nachum Z, 1999, AVIAT SPACE ENVIR MD, V70, P1106 Nachum Z, 2001, LARYNGOSCOPE, V111, P851, DOI 10.1097/00005537-200105000-00018 Newton HB, 2001, AM FAM PHYSICIAN, V63, P2211 PARELL GJ, 1993, ARCH OTOLARYNGOL, V119, P455 REISSMAN P, 1990, AVIAT SPACE ENVIR MD, V61, P563 Satoh M, 1992, Nihon Jibiinkoka Gakkai Kaiho, V95, P499 Shupak A, 2003, LARYNGOSCOPE, V113, P2141, DOI 10.1097/00005537-200312000-00017 Shupak A, 1991, Ann Otol Rhinol Laryngol, V100, P788 STRUTZ J, 1993, HNO, V41, P401 Vandenhoven G, 2003, SPUMS, V33, P70 WENDLING J, 2001, TAUCHTAUGLICHKEIT MA, P86 WILMSHURST P, 1990, LANCET, V336, P1071, DOI 10.1016/0140-6736(90)92546-T NR 25 TC 23 Z9 22 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1531-7129 J9 OTOL NEUROTOL JI Otol. Neurotol. PD JUN PY 2007 VL 28 IS 4 BP 447 EP 454 DI 10.1097/MAO.0b013e318030d356 PG 8 WC Clinical Neurology; Otorhinolaryngology SC Neurosciences & Neurology; Otorhinolaryngology GA 173DP UT WOS:000246854000004 PM 17417111 ER PT J AU Olzowy, B Canis, M Hempel, JM Mazurek, B Suckfull, M AF Olzowy, Bernhard Canis, Martin Hempel, John-Martin Mazurek, Birgit Suckfuell, Markus TI Effect of atorvastatin on progression of sensorineural hearing loss and tinnitus in the elderly: Results of a prospective, randomized, double-blind clinical trial SO OTOLOGY & NEUROTOLOGY LA English DT Article DE atorvastatin; presbycusis; prevention; sensorineural hearing loss; statins; tinnitus ID MULTICENTER; FIBRINOGEN; DISEASE AB Objective: To test whether the 3-hydroxy-3-methylglutarylcoenzyme A reductase inhibitor atorvastatin can slow down the progression of presbycusis. Patients: Fifty patients 60- to 75-years-old with presbycusis and moderately elevated serum cholesterol. Intervention(s): In a double-blind design, patients were randomly assigned to treatment with either atorvastatin (40 mg/d orally) or placebo. Main Outcome Measure(s): Pure-tone audiometry and tinnitus evaluation at enrolment and after 7 and 13 months. Results: Development of hearing thresholds after 7 and 13 months showed no significant differences between the groups. Tinnitus score continuously improved in the atorvastatin group (34.8 at 7 and 27.6 at 13 mo), whereas it slightly deteriorated in the placebo group (24.8 at 7 and 26.8 at 13 mo). The effect on tinnitus was a tendency without statistic significance (p) = 0.0833). Conclusion: Atorvastatin had no effect on the development of hearing thresholds, but resulted in a trend toward a relief of tinnitus. C1 Univ Munich, Klin & Poliklin Hals Nasen Ohrenheilkunde, D-81377 Munich, Germany. Univ Med Berlin, Charite, Tinnituszentrum, Klin & Poliklin Hals Nasen Ohrenheilkunde, Berlin, Germany. RP Olzowy, B (reprint author), Univ Munich, Klin & Poliklin Hals Nasen Ohrenheilkunde, Marchioninistr,15, D-81377 Munich, Germany. EM bernhard.olzowy@med.uni-muenchen.de CR AXELSSON A, 1985, ACTA OTO-LARYNGOL, V100, P379, DOI 10.3109/00016488509126561 Nguyen TVN, 1998, OTOLARYNG HEAD NECK, V119, P14, DOI 10.1016/S0194-5998(98)70167-6 Dujovne CA, 2000, AM J CARDIOL, V85, P350, DOI 10.1016/S0002-9149(99)00745-6 Feron O, 2001, CIRCULATION, V103, P113 GATES GA, 1993, ARCH OTOLARYNGOL, V119, P156 GOEBEL G, 1994, HNO, V42, P166 Megighian D, 2000, GERONTOLOGY, V46, P199, DOI 10.1159/000022160 Renders L, 2001, NEPHROL DIAL TRANSPL, V16, P141, DOI 10.1093/ndt/16.1.141 SIDMAN JD, 1988, ANN OTO RHINOL LARYN, V97, P9 Suckfull M, 2002, LANCET, V360, P1811, DOI 10.1016/S0140-6736(02)11768-5 NR 10 TC 16 Z9 19 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1531-7129 J9 OTOL NEUROTOL JI Otol. Neurotol. PD JUN PY 2007 VL 28 IS 4 BP 455 EP 458 DI 10.1097/01.mao.0000271673.33683.7b PG 4 WC Clinical Neurology; Otorhinolaryngology SC Neurosciences & Neurology; Otorhinolaryngology GA 173DP UT WOS:000246854000005 PM 17529847 ER PT J AU Mackle, T Rawluk, D Walsh, RM AF Mackle, Tara Rawluk, Daniel McConn Walsh, Rory TI Atypical clinical presentations of vestibular schwannomas SO OTOLOGY & NEUROTOLOGY LA English DT Article DE atypical symptoms; vestibular schwannoma ID ACOUSTIC NEUROMA PATIENTS; SYMPTOMS; HEARING; TUMORS AB Objective: A significant number of patients with vestibular schwannomas present atypically, with none of the classical symptoms of unilateral sensorineural hearing loss, tinnitus, and/or dysequilibrium. The aim of this study is to highlight those patients with unusual clinical symptoms. Study Design: The clinical data of all patients who presented to the vestibular schwannoma clinic at Beaumont Hospital over the past 12 years was prospectively recorded in a computerized database. This paper reviews the atypical presenting symptoms. Results: Three hundred ninety-eight patients were included in this study. A total of 3.7% of patients presented with atypical symptoms only. Conclusion: A significant subgroup, 3.7% in our study, did not present with the audiovestibular symptoms classically associated with vestibular schwannoma. Clinician awareness of the atypical clinical symptoms may lead to earlier detection of these lesions. C1 Beaumont Hosp, Dept Otolaryngol Head & Neck Surg, Dublin, Ireland. Beaumont Hosp, Dept Neurosurg, Dublin, Ireland. RP Mackle, T (reprint author), 1 Churchfields,Milltownbridge Rd, Dublin 14, Ireland. EM mackle_tara@hotmail.com CR Baguley DM, 1997, J LARYNGOL OTOL, V111, P1022 ECKERMEIER L, 1979, ARCH OHREN NASEN KEH, V222, P1, DOI 10.1007/BF00456332 EDWARDS CH, 1951, BRAIN, V74, P144, DOI 10.1093/brain/74.2.144 LEONARD JR, 1970, ARCHIV OTOLARYNGOL, V91, P117 Magdziarz DD, 2000, OTOLARYNG HEAD NECK, V122, P157, DOI 10.1016/S0194-5998(00)70232-4 MATHEW GD, 1978, LARYNGOSCOPE, V88, P1893 MOFFAT DA, 1994, J LARYNGOL OTOL, V108, P116 MOFFAT DA, 1993, J LARYNGOL OTOL, V107, P290, DOI 10.1017/S0022215100122856 MOFFAT DA, 1995, CLIN OTOLARYNGOL, V20, P80, DOI 10.1111/j.1365-2273.1995.tb00018.x MORRISON AW, 1975, ACOUSTIC NEUROMA, P46 Morrison GAJ, 1996, CLIN OTOLARYNGOL, V21, P80, DOI 10.1111/j.1365-2273.1996.tb01030.x Olsen A, 1944, J NEUROSURG, V1, P371, DOI 10.3171/jns.1944.1.6.0371 Saleh EA, 1996, AM J OTOL, V17, P127 SELESNICK SH, 1993, LARYNGOSCOPE, V103, P431 SELESNICK SH, 1993, LARYNGOSCOPE, V103, P437 Shiffman F, 1973, Otolaryngol Clin North Am, V6, P189 STEWART TJ, 1975, ARCH OTOLARYNGOL, V101, P91 VANLEEUWEN JPPM, 1995, LARYNGOSCOPE, V105, P701, DOI 10.1288/00005537-199507000-00006 NR 18 TC 1 Z9 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1531-7129 J9 OTOL NEUROTOL JI Otol. Neurotol. PD JUN PY 2007 VL 28 IS 4 BP 526 EP 528 DI 10.1097/mao.0b013e3180340a4d PG 3 WC Clinical Neurology; Otorhinolaryngology SC Neurosciences & Neurology; Otorhinolaryngology GA 173DP UT WOS:000246854000018 PM 17414179 ER PT J AU Church, MW Parent-Jenkins, L Rozzelle, AA Eldis, FE Kazzi, SNJ AF Church, Michael W. Parent-Jenkins, Leslie Rozzelle, Arlene A. Eldis, Frances E. Kazzi, S. Nadya J. TI Auditory brainstem response abnormalities and hearing loss in children with craniosynostosis SO PEDIATRICS LA English DT Article DE Apert syndrome; Arnold-Chiari malformation; auditory brainstem response; central auditory processing disorder; conductive hearing loss; craniosynostosis; Crouzon syndrome; fibroblast growth factor receptor; Jackson-Weiss syndrome; Pfeiffer syndrome; recurrent otitis media; sensorineural hearing loss; tinnitus; vertigo ID INTENSIVE-CARE NURSERY; FETAL ALCOHOL SYNDROME; EVOKED-POTENTIALS; APERT-SYNDROME; MICROVASCULAR DECOMPRESSION; PFEIFFER SYNDROME; SURGICAL DECOMPRESSION; CHIARI MALFORMATION; SELECTION CRITERIA; CROUZON-SYNDROME AB OBJECTIVES. Craniosynostosis is a devastating disorder characterized by premature closure of the cranial plates before or shortly after birth. This results in an abnormally shaped skull, face, and brain. Little is known about hearing disorders in such patients, and nothing has been published about their auditory brainstem responses. Our objective was to evaluate such patients for auditory brainstem response and hearing disorders with the long-term goal of improving patient evaluation and management. PATIENTS AND METHODS. We evaluated the auditory brainstem responses, hearing, and brain images of children with fibroblast growth factor receptor 2 craniosynostosis (n = 11). RESULTS. Prolongation of the auditory brainstem response I-to-III interpeak latency was a frequent characteristic of fibroblast growth factor receptor 2 craniosynostosis, occurring in 91% of our patients. Prolongation of the III-to-V interpeak latency was an occasional characteristic, occurring in 27% of our patients. Whenever the I-to-III interpeak latency was prolonged, wave II was always abnormal. Associated morbidities included sensorineural hearing loss (27%), recurrent otitis media (100%), and Arnold-Chiari malformation (27%). Cranial decompression improved the interpeak latencies of 2 children. CONCLUSIONS. These previously undocumented auditory brainstem response abnormalities reflect abnormal neural transmission, which could cause peripheral and central auditory processing disorders. We speculate that the major pathogenic basis of the I-to-III interpeak latency and wave II abnormalities is compression of the auditory nerve as it passes through the internal auditory meatus and posterior fossa, which would explain the auditory nerve hearing loss, tinnitus, and vertigo that affect these children. Awareness of these abnormalities could lead to important advancements in the auditory and neurosurgical assessment and management of this overlooked patient group. We provide recommendations for the improved assessment and management of these patients. In particular, we recommend that auditory brainstem response diagnostics become standard clinical care for this patient group as the best way to detect auditory nerve compression. C1 Wayne State Univ, Sch Med, Dept Obstet & Gynecol, Detroit, MI 48201 USA. Wayne State Univ, Sch Med, Dept Pediat, Detroit, MI 48201 USA. Childrens Hosp Michigan, Dept Plast Surg, Detroit, MI 48201 USA. Childrens Hosp Michigan, Commun Disorders Clin, Detroit, MI 48201 USA. RP Church, MW (reprint author), CS Mott Ctr Human Growth & Dev, 275 F Hancock, Detroit, MI 48201 USA. 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The aim of this paper is to summarize the partially adverse effects of 567 tDCS sessions over motor and non-motor cortical areas (occipital, temporal, parietal) from the last 2 years, on work performed in our laboratories. One-hundred and two of our subjects who participated in our tDCS studies completed a questionnaire. The questionnaire contained rating scales regarding the presence and severity of headache, difficulties in concentrating, acute mood changes, visual perceptual changes and any discomforting sensation like pain, tingling, itching or burning under the electrodes, during and after tDCS. Participants were healthy subjects (75.5%), migraine patients (8.8%), post-stroke patients (5.9%) and tinnitus patients (9.8%). During tDCS a mild tingling sensation was the most common reported adverse effect (70.6%), moderate fatigue was felt by 35.3% of the subjects, whereas a light itching sensation under the stimulation electrodes occurred in 30.4% of cases. After tDCS headache (11.8%), nausea (2.9%) and insomnia (0.98%) were reported, but fairly infrequently. In addition, the incidence of the itching sensation (p = 0.02) and the intensity of tingling sensation (p=0.02) were significantly higher during tDCS in the group of the healthy subjects, in comparison to patients; whereas the occurrence of headache was significantly higher in the patient group (p = 0.03) after the stimulation. Our results suggest that tDCS applied to motor and non-motor areas according to the present tDCS safety guidelines, is associated with relatively minor adverse effects in healthy humans and patients with varying neurological disorders. (c) 2007 Elsevier Inc. All rights reserved. C1 Univ Gottingen, Dept Clin Neurophysiol, D-37075 Gottingen, Germany. RP Poreisz, C (reprint author), Univ Gottingen, Dept Clin Neurophysiol, Robert Koch Str 40, D-37075 Gottingen, Germany. 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Bull. PD MAY 30 PY 2007 VL 72 IS 4-6 BP 208 EP 214 DI 10.1016/j.brainresbull.2007.01.004 PG 7 WC Neurosciences SC Neurosciences & Neurology GA 171RQ UT WOS:000246753500005 PM 17452283 ER PT J AU Bauer, CA Brozoski, TJ Myers, K AF Bauer, Carol A. Brozoski, Thomas J. Myers, Kristin TI Primary afferent dendrite degeneration as a cause of tinnitus SO JOURNAL OF NEUROSCIENCE RESEARCH LA English DT Article DE tinnitus; animal model; neural degeneration; cochlea ID DORSAL COCHLEAR NUCLEUS; AUDITORY-NERVE FIBERS; DIFFERING SPONTANEOUS RATE; HAIR CELL LOSS; HEARING-LOSS; CENTRAL PROJECTIONS; NOISE EXPOSURE; GUINEA-PIG; MODEL; SOUND AB Chronic tinnitus affects millions of people, but the mechanisms responsible for the development of this abnormal sensory state remain poorly understood. This study examined the type and extent of cochlear damage that occurs after acoustic trauma sufficient to induce chronic tinnitus in rats. Tinnitus was evaluated by using a conditioned suppression method of behavioral testing. Cochlear damage was assessed 6 months after acoustic trauma. There was minimal loss of inner and outer hair cells in the exposed cochleas of subjects demonstrating evidence of tinnitus. However, a significant loss of large-diameter fibers in the osseous spiral lamina of exposed cochleas of trauma subjects was observed. The significance of this finding in the context of a model of tinnitus is discussed. (c) 2007 Wiley-Liss, Inc. C1 So Illinois Univ, Sch Med, Div Otolaryngol Head & Neck Surg, Springfield, IL 62794 USA. RP Bauer, CA (reprint author), So Illinois Univ, Sch Med, Div Otolaryngol Head & Neck Surg, Springfield, IL 62794 USA. 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Neurosci. Res. PD MAY 15 PY 2007 VL 85 IS 7 BP 1489 EP 1498 DI 10.1002/jnr.21259 PG 10 WC Neurosciences SC Neurosciences & Neurology GA 174GJ UT WOS:000246929900013 PM 17393482 ER PT J AU Mittal, MK Kallan, MJ Durbin, DR AF Mittal, Manoj K. Kallan, Michael J. Durbin, Dennis R. TI Breathing difficulty and tinnitus among children exposed to airbag deployment SO ACCIDENT ANALYSIS AND PREVENTION LA English DT Article DE passenger airbag; tinnitus; breathing difficulty; first-generation airbag; second-generation airbag; seating row ID AUTOMOBILE AIRBAG; HEARING-LOSS; OTOLOGIC INJURIES; FRONTAL CRASHES; SYSTEM; NOISE; BAGS; VEHICLES; SAFETY AB Objective: To assess the incidence of breathing difficulty and tinnitus in children involved in motor vehicle crashes with and without passenger airbag (PAB) deployment, and its relationship to seating position and to whether the airbag deployed was first versus second-generation. Methods: We studied motor vehicle crashes with child passengers, over a 3-year period, in three large regions of the United States, by means of telephone interviews with the driver/parent. The crashes were classified into those with and without a PAB deployment. Complete data were collected on 7383 children in 4817 crashes, who, because of the sample design of the study, represent an estimated 120,987 children in 83,267 crashes. Results: Among children involved in crashes with PAB deployment, 6.6% complained of breathing difficulty versus 1.4% without airbag deployment (OR 5.2, 95% CI 3.3-8.2). The corresponding figures for tinnitus were 5.0% versus 0.7% (OR 7.4, 95% CI 4.0-13.7). Analysis of data for children exposed to PABs indicated that 14. 1 % of children in the front seat versus 1. 1 % in the rear complained of tinnitus (OR 14.4, 95% CI 5.9-34.7). Seating row did not significantly affect the incidence of breathing difficulty. The type of airbag deployed did not significantly affect the incidence of breathing difficulty or of tinnitus. Conclusion: Breathing difficulty and tinnitus were much more common among childrer in crashes with PAB deployment as against those without PAB deployment. Among children in crashes with PAB deployment, tinnitus was about 14 times more likely for those sitting in the front versus rear seat. The incidence of breathing difficulty was not affected significantly by seating row. Introduction of second-generation airbags has not affected the incidence of breathing difficulty or of tinnitus. (C) 2006 Elsevier Ltd. All rights reserved. C1 Childrens Hosp Philadelphia, Div Emergency Med, Philadelphia, PA 19104 USA. Univ Penn, Sch Med, Ctr Clin Epidemiol & Biostat, Philadelphia, PA 19104 USA. RP Mittal, MK (reprint author), Childrens Hosp Philadelphia, Div Emergency Med, 34th St & Civi Ctr Blvd, Philadelphia, PA 19104 USA. EM mittal@email.chop.edu; mkallan@cceb.upenn.edu; durbind@email.chop.edu CR Arbogast KB, 2005, ARCH PEDIAT ADOL MED, V159, P342, DOI 10.1001/archpedi.159.4.342 BANGLMAIER RF, 2003, 47 ANN P ASS ADV AUT, V47, P25 Boyd BC, 2002, ORAL SURG ORAL MED O, V94, P143, DOI 10.1067/moe.2002.121707 Braver ER, 1997, JAMA-J AM MED ASSOC, V278, P1437, DOI 10.1001/jama.278.17.1437 Buckley G, 1999, BRIT MED J, V318, P499 Chao N, 2004, PEDIATR EMERG CARE, V20, P683, DOI 10.1097/01.pec.0000142955.88759.42 DEY AN, 2005, VITAL HLTH STAT, V10 Durbin Dennis R, 2003, Traffic Inj Prev, V4, P58, DOI 10.1080/15389580309853 Durbin DR, 2001, ACCIDENT ANAL PREV, V33, P407, DOI 10.1016/S0001-4575(00)00054-3 Epperly NA, 1997, AM SURGEON, V63, P979 Glassbrenner D, 2004, J SAFETY RES, V35, P237, DOI 10.1016/j.jsr.2004.03.010 GROSS KB, 1995, J TRAUMA, V38, P521, DOI 10.1097/00005373-199504000-00010 GROSS KB, 1994, AM J RESP CRIT CARE, V150, P408 Huelke DF, 1999, ACCIDENT ANAL PREV, V31, P789, DOI 10.1016/S0001-4575(99)00032-9 KIUCHI T, 1998, P 16 INT TECHN C ENH, P2518 MATTOX DE, 1995, P 18 MIDW M ASS RES Mazieres J, 2002, REV MAL RESPIR, V19, P537 McFeely WJ, 1999, OTOLARYNG HEAD NECK, V121, P367, DOI 10.1016/S0194-5998(99)70222-6 Morris MS, 1998, ARCH OTOLARYNGOL, V124, P507 NIXON CW, 1969, HUMAN AUDITORY RESPO Pérez-Camarero E R, 2000, Eur J Emerg Med, V7, P160 Price GR, 1999, J ACOUST SOC AM, V106, P2629, DOI 10.1121/1.428092 Saunders JE, 1998, OTOLARYNG HEAD NECK, V118, P228, DOI 10.1016/S0194-5998(98)80021-1 *WHO, 1980, INT PROGR CHEM SAF E Wittenberg E, 1999, PEDIATRICS, V104, P1247, DOI 10.1542/peds.104.6.1247 Yaremchuk K, 2001, OTOLARYNG HEAD NECK, V125, P130, DOI 10.1067/mhn.2001.117872 NR 26 TC 2 Z9 2 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0001-4575 J9 ACCIDENT ANAL PREV JI Accid. Anal. Prev. PD MAY PY 2007 VL 39 IS 3 BP 624 EP 628 DI 10.1016/j.aap.2006.10.005 PG 5 WC Ergonomics; Public, Environmental & Occupational Health; Social Sciences, Interdisciplinary; Transportation SC Engineering; Public, Environmental & Occupational Health; Social Sciences - Other Topics; Transportation GA 173IV UT WOS:000246867600024 PM 17098204 ER PT J AU Magliulo, G Parrotto, D Sardella, B della Rocca, C Re, M AF Magliulo, Giuseppe Parrotto, Donato Sardella, Barbara della Rocca, Carlo Re, Massimo TI Cavernous hemangioma of the tympanic membrane and external ear canal SO AMERICAN JOURNAL OF OTOLARYNGOLOGY LA English DT Article AB Objectives: The aims of this study are to document the occurrence of a cavernous hemangioma of the tympanic membrane (TM) and external auditory canal (EAC) that invaded the middle ear spaces and to review the relevant literature. Methods: The clinical presentation, imaging studies, operative report, and histologic findings of this new case of cavernous hemangioma are reviewed. Results: A cavernous hemangioma of the TM and EAC involving the middle ear spaces was surgically excised without complications. The pulsatile tinnitus, which affected our patient at the same ear where the lesion was situated, disappeared after surgery. Our case represents the first documented cavernous hemangioma of the TM and EAC that invaded the middle ear spaces and the eighth case of cavernous hemangioma of the EAC/TM. Computed tomography is the method of choice in evaluating this lesion. Conclusions: Hemangiomas of the EAC and/or TM are extremely rare entities amenable to surgical excision. With magnetic resonance imaging, there is difficulty in defining the exact location of the tumor and degree of soft tissue involvement. (c) 2007 Elsevier Inc. All rights reserved. C1 Univ Roma La Sapienza, Dept Otohinolaryngol Anudiol & Phoniatr G Ferreri, Rome, Italy. Univ Roma La Sapienza, Dept Expt Med & Pathol, Rome, Italy. Univ Politecn Marche, OtoRhinoLaryngol Chair, Ancona, Italy. RP Magliulo, G (reprint author), Via Gregorio 7 & 80, I-00165 Rome, Italy. EM giuseppemagliuloorl@yahoo.com CR ANDRADE JM, 1983, AM J OTOL, V4, P198 BALKANY TJ, 1978, ARCH OTOLARYNGOL, V104, P296 FREEDMAN SI, 1972, ARCHIV OTOLARYNGOL, V96, P158 HAWKE M, 1987, J OTOLARYNGOL, V16, P40 JACKSON CG, 1990, AM J OTOL, V11, P117 KEMINK JL, 1983, AM J OTOL, V5, P125 Limb CJ, 2002, OTOLARYNG HEAD NECK, V126, P74, DOI 10.1067/mhn.2002.120697 Nager GT, 1993, PATHOLOGY EAR TEMPOR Reeck JB, 2002, LARYNGOSCOPE, V112, P1750, DOI 10.1097/00005537-200210000-00007 ROSAI J, 2004, SURG PATHOLOGY, P2285 NR 10 TC 9 Z9 9 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0196-0709 J9 AM J OTOLARYNG JI Am. J. Otolaryngol. PD MAY-JUN PY 2007 VL 28 IS 3 BP 180 EP 183 DI 10.1016/j.amjoto.2006.03.012 PG 4 WC Otorhinolaryngology SC Otorhinolaryngology GA 172GT UT WOS:000246792800009 PM 17499135 ER PT J AU Savastano, M Brescia, G Marioni, G AF Savastano, Marina Brescia, Giuseppe Marioni, Gino TI Antioxidant therapy in idiopathic tinnitus: Preliminary outcomes SO ARCHIVES OF MEDICAL RESEARCH LA English DT Article DE idiopathic tinnitus; antioxidant therapy; reactive oxygen species ID FREE-RADICALS; SKELETAL-MUSCLE; VITAMIN-E; DISEASE; ENDOTHELIUM; INVOLVEMENT; EXERCISE; CELLS AB Background. Reactive oxygen species (ROS) play an important role in several pathogenic processes, damaging various structural and functional cellular components. The endothelium is at major risk of radical-induced lesions and this damage is most manifest in microcirculation. It has been recently observed that ROS are implicated in the pathology of the inner ear and the peripheral and central pathways. In a previous study we detected high serum values of ROS in subjects with idiopathic tinnitus. The purpose of the present study was to evaluate the validity of antioxidant treatment in tinnitus sufferers with high ROS values. Methods. The study considered 31 consecutive patients with unilateral idiopathic tinnitus. The mean pure tone audiometric threshold (PTA), tinnitus loudness, subjective disturbance level [visual analogue scale (VAS) determination], and the indirect ROS dosage 48 h before and after medical treatment were evaluated. Patients underwent an 18-week oral treatment with a mix of phospholipids and vitamins (glycerophosphorylcholine, glycerophosphorylethanolamine, beta-carotene, vitamin C, vitamin E). Results. ROS levels were significantly reduced following antioxidant treatment (malonaldehyde: 2.10 vs. 1.98 mu mol/dL, p = 0.003; 4-hydroxynonenal: 2.36 vs. 2.16 mu mol/dL, p = 0.002) In addition, great improvement was observed in the reduction of tinnitus (VAS and tinnitus loudness evaluations). No significant changes in audiometric threshold occurred. Conclusions. Oral antioxidant therapy in patients with idiopathic tinnitus seems to reduce the subjective discomfort and tinnitus intensity and may be considered as an additional treatment modality. (C) 2007 IMSS. Published by Elsevier Inc. C1 Univ Padua, Dept Otolaryngol Head & Neck Surg, I-35128 Padua, Italy. RP Savastano, M (reprint author), Univ Padua, Dept Otolaryngol Head & Neck Surg, Via Giustiniani 2, I-35128 Padua, Italy. 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Med. Res. PD MAY PY 2007 VL 38 IS 4 BP 456 EP 459 DI 10.1016/j.arcmed.2006.12.004 PG 4 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA 160HE UT WOS:000245930700015 PM 17416295 ER PT J AU Mortazavi, SMJ Ahmadi, J Shariati, M AF Mortazavi, S. M. J. Ahmadi, J. Shariati, M. TI Prevalence of subjective poor health symptoms associated with exposure to electromagnetic fields among university students SO BIOELECTROMAGNETICS LA English DT Article DE electromagnetic fields (EMF); electromagnetic hypersensitivity (EHS); symptoms; sensations ID PERCEIVED ELECTRICAL HYPERSENSITIVITY; CELLULAR TELEPHONES; PROVOCATION; HEADACHE AB The number of people complaining about different symptoms that may be associated with exposure to electromagnetic fields (EMF) has increased rapidly during past years. Students use both mobile phones and video display terminals frequently. The purpose of this study was to investigate the association of mobile phone use and EMF health hazards. Basic demographic data and self-reported symptoms were sought using a questionnaire administered to all apparently healthy students at Rafsanjan University of Medical Sciences (RUMS) and Vali-e-Asr University (VAU). Questions about some major confounding factors such as age, gender, amount of video display terminal work were also included. Exact Fischer Test was used for data analysis. Among self-reported symptoms, headache (53.5%), fatigue (35.6%), difficulties in concentration (32.5%), vertigo/dizziness (30.4%), attention disorders (28.8%), nervousness (28.1%), palpitation (14.7%), low back pain (14.3%), myalgia (12.4%), and tinnitus (9.9%) were the main self-reported symptoms. No significant differences in the prevalence of these symptoms were found between CRT users and those who did not use CRTs. A significant association was found between cordless phone use and difficulties in concentration (P <.05) or attention disorders (P <.05). However, after correction of the gender role, these differences were not significant. No association was found between mobile phone use and the above-mentioned symptoms. No significantly higher prevalence of self-reported symptoms was found in individuals who had used mobile phones, video display terminals or cordless phones more frequently than others. Mass-media's lack of interest in the possible hazards of exposure to EMF in developing countries can explain the difference observed between the results of this study and those of other researchers in some developed countries who have shown an association between EMF exposure and the prevalence of self-reported subjective symptoms. This finding can confirm the results obtained in provocative studies which indicated the role of psychological factors in electromagnetic hypersensitivity. More research is needed to clarify whether daily environmental EMF may cause health problems. Bioelectromagnetics 28:326-330, 2007. (c) 2007 Wiley-Liss, Inc. C1 Rafsanjan Univ Med Sci, Sch Med, Dept Biochem Biophys, Rafsanjan, Iran. Rafsanjan Univ Med Sci, Ali Ibn Abitaleb Hosp, Res Dev Ctr, Rafsanjan, Iran. Rafsanjan Univ Med Sci, Sch Med, Dept Anat, Rafsanjan, Iran. RP Mortazavi, SMJ (reprint author), Rafsanjan Univ Med Sci, Sch Med, Dept Biochem Biophys, Enghelab Sq, Rafsanjan, Iran. EM jamo23@lycos.com RI Mortazavi, SMJ/D-5830-2011 CR Al-Khlaiwi T, 2004, SAUDI MED J, V25, P732 BERGDAHL J, 1995, ACTA ODONTOL SCAND, V53, P304, DOI 10.3109/00016359509005992 Chia SE, 2000, ENVIRON HEALTH PERSP, V108, P1059, DOI 10.1289/ehp.001081059 Frey AH, 1998, ENVIRON HEALTH PERSP, V106, P101, DOI 10.1289/ehp.98106101 GOBBA F, 2002, EPIDEMIOL PREV, V4, P171 Hansson Mild K, 1998, ARBETSLIVSRAPPORT, V23, P1 Hietanen M, 2002, BIOELECTROMAGNETICS, V23, P264, DOI 10.1002/bem.10016 HILLER L, 2001, HYPERSENSITIVITY ELE Hocking B, 1998, OCCUP MED-OXFORD, V48, P357, DOI 10.1093/occmed/48.6.357 Koivisto M, 2001, BIOELECTROMAGNETICS, V22, P212, DOI 10.1002/bem.41 Leitgeb Norbert, 2005, Wien Med Wochenschr, V155, P237, DOI 10.1007/s10354-005-0175-3 Leitgeb N, 2003, BIOELECTROMAGNETICS, V24, P387, DOI 10.1002/bem.10138 Lyskov E, 2001, BIOELECTROMAGNETICS, V22, P457, DOI 10.1002/bem.73 Lyskov E, 2001, INT J PSYCHOPHYSIOL, V42, P233, DOI 10.1016/S0167-8760(01)00141-6 Maes A, 2000, BIOELECTROMAGNETICS, V21, P589, DOI 10.1002/1521-186X(200012)21:8<589::AID-BEM5>3.0.CO;2-X Markova E, 2005, ENVIRON HEALTH PERSP, V113, P1172, DOI 10.1289/ehp.7561 Meo Sultan A., 2005, International Journal of Occupational Medicine and Environmental Health, V18, P53 Rubin GJ, 2005, PSYCHOSOM MED, V67, P224, DOI 10.1097/01.psy.0000155664.13300.64 Rubin GJ, 2006, BRIT MED J, V332, P886, DOI 10.1136/bmj.38765.519850.55 Sandstrom M, 1997, J OCCUP ENVIRON MED, V39, P15, DOI 10.1097/00043764-199701000-00006 Sandstrom M, 2003, INT J PSYCHOPHYSIOL, V49, P227, DOI 10.1016/S0167-8760(03)00145-4 Verschaeve L, 1998, MUTAT RES-REV MUTAT, V410, P141, DOI 10.1016/S1383-5742(97)00037-9 NR 22 TC 28 Z9 29 PU WILEY-LISS PI HOBOKEN PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0197-8462 J9 BIOELECTROMAGNETICS JI Bioelectromagnetics PD MAY PY 2007 VL 28 IS 4 BP 326 EP 330 DI 10.1002/bem.20305 PG 5 WC Biology; Biophysics SC Life Sciences & Biomedicine - Other Topics; Biophysics GA 164TY UT WOS:000246258600010 PM 17330851 ER PT J AU Carlbring, P Brunt, S Bohman, S Austin, D Richards, J Ost, LG Andersson, G AF Carlbring, Per Brunt, Sara Bohman, Susanne Austin, David Richards, Jeffrey Ost, Lars-Goran Andersson, Gerhard TI Internet vs. paper and pencil administration of questionnaires commonly used in panic/agoraphobia research SO COMPUTERS IN HUMAN BEHAVIOR LA English DT Article DE Internet administration; panic disorder; questionnaire; psychometrics ID PANIC DISORDER; PSYCHOMETRIC PROPERTIES; RANDOMIZED-TRIAL; DEPRESSION SCALE; INVENTORY; ANXIETY; HELP; FEAR; AGORAPHOBIA; TINNITUS AB The aim of this study was to investigate the psychometric properties of Internet administered questionnaires used in panic research. Included were 494 people who had registered for an Internet-based treatment program for panic disorder (PD). Participants were randomly assigned to fill in the questionnaires either on the Internet or the paper-and-pencil versions, and then to fill in the same questionnaires again the next day using the other format. The questionnaires were the body sensations questionnaire [BSQ; Chambless, D. L., Caputo, G. C., Bright, P., & Gallagher, R. (1984). Assessment of fear of fear in agoraphobics: the body sensations questionnaire and the agoraphobic cognitions questionnaire. Journal of Consulting and Clinical Psychology, 52, 1090-1097], agoraphobic cognitions questionnaire [ACQ; Chambless, D. L., Caputo, G. C., Bright, P., & Gallagher, R. (1984). Assessment of fear of fear in agoraphobics: the body sensations questionnaire and the agoraphobic cognitions questionnaire. Journal of Consulting and Clinical Psychology, 52, 1090-1097], mobility inventory [MI; Chambless, D. L., Caputo, G., Jasin, S., Gracely, E. J., & Williams, C. (1985). The mobility inventory for agoraphobia. Behaviour Research and Therapy, 23, 35-44], beck anxiety inventory [BAI; Beck, A. T., Epstein, N., Brown, G., & Steer, R. A. (1988). An inventory for measuring clinical anxiety: psychometric properties. Journal of Consulting and Clinical Psychology, 56, 893-897], beck depression inventory 11 [Beck, A. T., & Steer, R. A. (1996). Beck Depression Inventory, Manual, Svensk version (Swedish version). Fagernes, Norway: Psykologiforlaget, AB], quality of life inventory [QOLI; Frisch, M. B., Cornell, J., Villanueva, M., & Retzlaff, P. J. (1992). Clinical validation of the quality of life inventory. A measure of life satisfaction for use in treatment planning and outcome assessment. Psychological Assessment, 4, 92-101], and montgomery angstrom sberg depression rating scale [MADRS; Svanborg, P., & angstrom sberg, M. (1994). A new self-rating scale for depression and anxiety states based on the comprehensive psychopathological rating scale. ACTA Psychiatrica Scandinavica, 89, 21-28]. Results showed largely equivalent psychometric properties for the two administration formats (Cronbach's alpha between 0.79 and 0.95). The results also showed high and significant correlations between the Internet and the paper-and-pencil versions. Analyses of order effects showed an interaction effect for the BSQ and the MI (subscale Accompanied), a main effect was identified for ACQ, MI-Alone, BAI and BDIII. However, in contrast to previous research, the Internet version did not consistently generate higher scores and effect sizes for the differences were generally low. Given the presence of an interaction effect, we recommend that the administration format should be stable in research across measurement points. Finally, the findings suggest that Internet versions of questionnaires used in PD research can be used with confidence. (c) 2005 Elsevier Ltd. All rights reserved. C1 Linkoping Univ, Dept Behav Sci, S-58183 Linkoping, Sweden. Uppsala Univ, Dept Psychol, Uppsala, Sweden. Monash Univ, Sch Primary Hlth Care, Melbourne, Vic 3004, Australia. Stockholm Univ, Dept Psychol, S-10691 Stockholm, Sweden. RP Carlbring, P (reprint author), Linkoping Univ, Dept Behav Sci, S-58183 Linkoping, Sweden. EM perca@ibv.liu.se RI Andersson, Gerhard/J-8529-2012 OI Andersson, Gerhard/0000-0003-4753-6745 CR Abelson RP, 1995, STAT PRINCIPLED ARGU Alcaniz M, 2003, CYBERPSYCHOL BEHAV, V6, P355, DOI 10.1089/109493103322278727 Andersson G, 2002, PSYCHOSOM MED, V64, P810, DOI 10.1097/01.PSY.0000031577.42041.F8 Andersson G, 2003, J PSYCHOSOM RES, V55, P259, DOI 10.1016/S0022-3999(02)00575-5 Antony M. 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B., 1992, PSYCHOL ASSESSMENT, V4, P92, DOI DOI 10.1037/1040-3590.4.1.92 Gillis MM, 1995, PSYCHOL ASSESSMENT, V7, P450, DOI 10.1037/1040-3590.7.4.450 GOULD RA, 1993, CLIN PSYCHOL REV, V13, P169, DOI 10.1016/0272-7358(93)90039-O Klein B, 2001, BEHAV COGN PSYCHOTH, V29, P113, DOI 10.1017/S1352465801001138 MONTGOMERY SA, 1979, BRIT J PSYCHIAT, V134, P382, DOI 10.1192/bjp.134.4.382 OST LG, 1997, UNPUB QUALITY LIFE A Pasveer KA, 1998, BEHAV RES METH INS C, V30, P309, DOI 10.3758/BF03200659 Reed V, 1998, J PSYCHIAT RES, V32, P335, DOI 10.1016/S0022-3956(98)00014-4 Reips U., 2000, PSYCHOL EXPT INTERNE, P89, DOI 10.1016/B978-012099980-4/50005-8 Richards Jeffrey, 2003, Cognitive Behaviour Therapy, V32, P125, DOI 10.1080/16506070302318 Richards Jeffrey C., 2002, Cognitive Behaviour Therapy, V31, P41, DOI 10.1080/16506070252823652 Schmidt WC, 1997, BEHAV RES METH INS C, V29, P274, DOI 10.3758/BF03204826 *STAT SWED, 2004, PRIV ANV DAT INT Strom L, 2004, J CONSULT CLIN PSYCH, V72, P113, DOI 10.1037/0022-006X.72.1.113 SVANBORG P, 1994, ACTA PSYCHIAT SCAND, V89, P21, DOI 10.1111/j.1600-0447.1994.tb01480.x Taylor S., 2000, UNDERSTANDING TREATI NR 38 TC 125 Z9 134 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0747-5632 J9 COMPUT HUM BEHAV JI Comput. Hum. Behav. PD MAY PY 2007 VL 23 IS 3 BP 1421 EP 1434 DI 10.1016/j.chb.2005.05.002 PG 14 WC Psychology, Multidisciplinary; Psychology, Experimental SC Psychology GA 137JM UT WOS:000244288900027 ER PT J AU Ross, UH Lange, O Unterrainer, J Laszig, R AF Ross, U. H. Lange, O. Unterrainer, J. Laszig, R. TI Ericksonian hypnosis in tinnitus therapy: effects of a 28-day inpatient multimodal treatment concept measured by Tinnitus-Questionnaire and Health Survey SF-36 SO EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY LA English DT Article DE subjective tinnitus; quality of life; behavioural medicine; psychotherapy; hearing loss ID INFORMATION; MANAGEMENT AB For the first time, the therapeutic effects on subacute and chronic tinnitus of an inpatient multimodal treatment concept based on principles of Ericksonian hypnosis (EH) were examined by standardized criteria of the Tinnitus Questionnaire (TQ) and Health Survey (SF-36) within a controlled prospective, longitudinal study. A total of 393 patients were treated within an inpatient closed-group 28-day-setting based on a resource-oriented, hypnotherapeutic concept. The severity of tinnitus was assessed by TQ at times of admission, discharge and also at a 6- and 12-month follow-up. Health-related quality of life was evaluated before and after therapy using the SF-36. After therapy, a decrease in TQ score was seen in 90.5% of the patients with subacute tinnitus and in 88,3% of those with chronic tinnitus. Assessment of the TQ score at the end of therapy revealed highly significant improvements of 15.9/14.1 points in mean. Effect sizes in the treatment groups (0.94/0.80) were superior to those in the waiting-list controls (0.14/0.23). The TQ score remained stable in the follow-up controls. Significant improvement in health-related quality of life has been observed within the treatment groups depending on initial level of tinnitus serverity I-IV according to TQ. Using a multimodal treatment concept with emphasis on resource-activating approaches of EH the annoyance of tinnitus can be significantly reduced while health-related quality of life is enhanced within a comparatively short treatment period of 28 days. C1 Univ Freiburg, Inst Environm Med & Hosp Epidemiol, Freiburg, Germany. Univ Freiburg, Dept Neuropsychol, Freiburg, Germany. Univ Freiburg, Dept Otorhinolaryngol, Freiburg, Germany. Practice Otorhinolaryngol & Psychotherapy, D-79098 Freiburg, Germany. RP Ross, UH (reprint author), Practice Otorhinolaryngol & Psychotherapy, Luisenstr 6, D-79098 Freiburg, Germany. EM Dr-Ross@web.de CR ATTIAS J, 1993, AUDIOLOGY, V32, P205 Kaye J M, 1994, Ear Nose Throat J, V73, P309 Biesinger E, 1998, HNO, V46, P157, DOI 10.1007/s001060050215 Bullinger M, 1998, SF 36 FRAGEBOGEN GES Delb W, 2002, HNO, V50, P997, DOI 10.1007/s00106-002-0645-5 Flammer E., 2003, CONT HYPN, V20, P179, DOI 10.1002/ch.277 GERL W, 2001, HYPNOSE PSYCHOTHERAP, P240 Gilligan S, 1987, THERAPEUTIC TRANCES GILLIGAN S, 1997, COURAGE LIVE PRINCIP Goebel G, 1998, TINNITUS FRAGEBOGEN HALAMA P, 1992, EXPT KLIN HYPNOSE, V8, P49 Hallam RS., 1996, MANUAL TINNITUS QUES Hesse G, 2001, LARYNGO RHINO OTOL, V80, P503, DOI 10.1055/s-2001-17131 JASTREBOFF PJ, 1993, BRIT J AUDIOL, V27, P7, DOI 10.3109/03005369309077884 JWP Hazell, 1999, P 6 INT TINN SEM CAM KIRSCH I, 1995, J CONSULT CLIN PSYCH, V63, P214, DOI 10.1037//0022-006X.63.2.214 Kroner-Herwig B, 2003, J PSYCHOSOM RES, V54, P381, DOI 10.1016/S0022-3999(02)00400-2 MACLEOD C, 1992, BEHAV RES THER, V30, P151 Mason JDT, 1996, J LARYNGOL OTOL, V110, P117 NELTING M, 1999, P 6 INT TINN SEM CAM, P558 Rainville P, 1999, J COGNITIVE NEUROSCI, V11, P110, DOI 10.1162/089892999563175 ROSSI EL, 1994, MIND BODY THERAPY ME SCHMIDT G, 1985, HYPNOSE PSYCHOTHERAP, P31 SHIFFRIN RM, 1977, PSYCHOL REV, V84, P127, DOI 10.1037/0033-295X.84.2.127 Ware JE, 1993, SF 36 HLTH SURVEY MA NR 25 TC 7 Z9 7 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013 USA SN 0937-4477 J9 EUR ARCH OTO-RHINO-L JI Eur. Arch. Oto-Rhino-Laryn. PD MAY PY 2007 VL 264 IS 5 BP 483 EP 488 DI 10.1007/s00405-006-0221-9 PG 6 WC Otorhinolaryngology SC Otorhinolaryngology GA 153JL UT WOS:000245428800005 PM 17206402 ER PT J AU Lenarz, M Durisin, M Kamenetzki, P Becker, H Kreipe, HH Lenarz, T AF Lenarz, Minoo Durisin, Martin Kamenetzki, Petr Becker, Hartmut Kreipe, Hans-Heinrich Lenarz, Thomas TI Cavernous hemangioma of the internal auditory canal SO EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY LA English DT Article DE hemangioma; internal auditory canal; facial nerve ID TEMPORAL BONE HEMANGIOMAS; MANAGEMENT AB Hemangiomas rarely occur in the internal auditory canal. These tumors originate from the capillary bed of the epineurium surrounding the nerve and can either compress or infiltrate the nerve. Depending on location and the nerve of origin, these lesions can cause severe and progressive sensorineural hearing loss, tinnitus, facial nerve palsy, or vertigo even when they are relatively small. The presence of a small contrast-enhancing tumor in the internal auditory canal accompanied by severe sensorineural hearing loss and facial nerve palsy, should raise the suspicion of a hemangioma. Early recognition and surgical intervention in these benign tumors may improve the chance of preserving the functional integrity of the facial nerve and provides better results after nerve reconstruction. Due to their relative small size, the temporal bone CT-scan may show no evidence of pathological widening of the internal auditory canal or the typical intralesional calcifications at the time of presentation. MRI with Gadolinium is the imaging method of choice and a high index of clinical suspicion is necessary for the diagnosis of these tumors. In this paper we report about a 51-year-old male presented with right-sided sensory-neural deafness and facial nerve palsy, accompanied by severe tinnitus and ipsilateral loss of vestibular function due to a cavernous hemangioma in the internal auditory canal. C1 Hannover Med Sch, Dept Otorhinolaryngol, D-30625 Hannover, Germany. Hannover Med Sch, Dept Neuroradiol, D-30625 Hannover, Germany. Hannover Med Sch, Dept Pathol, D-30625 Hannover, Germany. RP Lenarz, T (reprint author), Hannover Med Sch, Dept Otorhinolaryngol, Carl Neuberg Str 1, D-30625 Hannover, Germany. EM Lenarz.Minoo@MH-Hannover.des CR BRACKMANN DE, 1980, OTOLARYNG HEAD NECK, V88, P555 EBY TL, 1992, AM J OTOL, V13, P223 ODONOUGHUE GM, 1994, NEUROTOLOGY, P1323 PAPPAS DG, 1989, OTOLARYNG HEAD NECK, V101, P27 Piccirillo E, 2004, ANN OTO RHINOL LARYN, V113, P431 NR 5 TC 7 Z9 7 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013 USA SN 0937-4477 J9 EUR ARCH OTO-RHINO-L JI Eur. Arch. Oto-Rhino-Laryn. PD MAY PY 2007 VL 264 IS 5 BP 569 EP 571 DI 10.1007/s00405-006-0226-4 PG 3 WC Otorhinolaryngology SC Otorhinolaryngology GA 153JL UT WOS:000245428800021 PM 17235534 ER PT J AU Hesse, G Schaaf, H AF Hesse, G. Schaaf, H. TI Music therapy in tinnitus SO HNO LA German DT Editorial Material C1 Ohr & Horinst Hessen, Psychosomat Klin Bad Arolsen, Tinnitus Klin, D-34454 Bad Arolsen, Germany. RP Hesse, G (reprint author), Ohr & Horinst Hessen, Psychosomat Klin Bad Arolsen, Tinnitus Klin, Grosse Allee 1-3, D-34454 Bad Arolsen, Germany. EM ghesse@schoen-kliniken.de CR *ADANO, 2000, ADANO SITZ, P1 DELB W, 2002, TINNITUS MANUAL TINN GEFFKEN R, 1998, OHRGERAUSCHE QUINTES Goebel G, 2001, OHRGERAUSCHE PSYCHOS GOEBEL G, 2001, HNO, V49, P1026 GOEBEL G, 2005, HNO PRAXIS HEUTE TIN, P19 Hallam R. S., 1984, CONTRIBUTIONS MED PS, P31 Hesse G, 2001, HNO PRAXIS HEUTE, V21, P197 Hesse G, 2001, HNO, V49, P764, DOI 10.1007/s001060170052 Hesse G, 2001, HNO, V49, P636, DOI 10.1007/s001060170061 JASTREBOFF PJ, 1993, BRIT J AUDIOL, V27, P7, DOI 10.3109/03005369309077884 KRONERHERWIG B, 2005, HNO PRAXIS HEUTE TIN, P125 Kroner-Herwig B., 1997, PSYCHOL BEHANDLUNG C Lenarz T, 1998, LARYNGO RHINO OTOL, V77, P54, DOI 10.1055/s-2007-996932 SCHAAF H, 2002, PSYCHOTHERAPIE TINNI Schaaf H, 2003, HNO, V51, P1005, DOI 10.1007/s00106-003-0967-y Zenner HP, 1998, HNO, V46, P699, DOI 10.1007/s001060050299 NR 17 TC 2 Z9 2 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013 USA SN 0017-6192 J9 HNO JI HNO PD MAY PY 2007 VL 55 IS 5 BP 328 EP 330 DI 10.1007/s00106-007-1570-4 PG 3 WC Otorhinolaryngology SC Otorhinolaryngology GA 166CI UT WOS:000246354400001 PM 17431561 ER PT J AU Argstatter, H Plinkert, P Bolay, HV AF Argstatter, H. Plinkert, P. Bolay, H. V. TI Music therapy for tinnitus patients SO HNO LA English DT Article DE music therapy; chronic tinnitus; efficacy; coacting factors ID RETRAINING THERAPY; MECHANISMS AB Background. Chronic tinnitus, one of the most common disorders in ENT medicine, requires comprehensive and interdisciplinary treatment. Objective. An innovative music therapy approach, developed at the German Center for Music Therapy Research in cooperation with the ENT clinic of the University of Heidelberg ("Heidelberg Model"), strives to integrate the tinnitus sound into a musically controllable acoustic process. The aim of the present study is to evaluate the effectiveness of this current treatment. Methods. We carried out a prospective, two-armed (music therapy group vs control group) study with 20 patients (10 males, 10 females; mean age 51 +/- 7 years), suffering from decompensated chronic tinnitus (mean score in the Tinnitus Questionnaire TQ=46.8 +/- 9.6). The target variables involved TQ values, pre- and post-measurements, and follow-up after 3 and 6 months. Results. Group comparison yields a highly statistically and clinically significant decrease in mean TQ-scores pre- and post in the music therapy group by 25 points or 52% on average as compared to 2 points (4%) in the control group [univariate ANOVA: ( F-(1,F-31)=14.19, P =0.001), effect size d=1.73]. Logarithmic regression analysis reveals a fast onset and long lasting effect of music therapy (B=-8.9; F-(1,F-125)=32.11, P =0.000). Discussion. The effectiveness of this highly economic approach was proven as the innovative music therapy concept yields statistically and clinically significant results which remain stable throughout follow-up. Further investigations with larger sample sizes and using brain imaging should strengthen these findings. C1 Deutsch Zentrum Musiktherap Forsch, Viktor Dulger Inst, DZM eV, D-69123 Heidelberg, Germany. Fach Hsch Heidelberg, Fak Musiktherapie, Heidelberg, Germany. Hals Nasen Ohren Univ Klin, Heidelberg, Germany. RP Argstatter, H (reprint author), Deutsch Zentrum Musiktherap Forsch, Viktor Dulger Inst, DZM eV, Maassstr 26, D-69123 Heidelberg, Germany. EM heike.argstatter@fh-heidelberg.de CR Andersson G, 1999, BRIT J AUDIOL, V33, P201 ARGSTATTER H, 2005, MUSIK TANZ KUNSTTHER, V16, P1, DOI 10.1026/0933-6885.16.1.1 Biesinger E, 1998, HNO, V46, P157, DOI 10.1007/s001060050215 D'Amelio R, 2004, HNO, V52, P599, DOI 10.1007/s00106-003-0944-5 Delb W, 2002, HNO, V50, P997, DOI 10.1007/s00106-002-0645-5 DELB W, 2002, TINNITUS MANUAL TINN Eysel-Gosepath K, 2004, HNO, V52, P431, DOI 10.1007/s00106-003-0929-4 Flor H, 2004, APPL PSYCHOPHYS BIOF, V29, P113, DOI 10.1023/B:APBI.0000026637.77671.f4 Franke G, 1995, SYMPTOM CHECKLISTE D Goebel G, 2001, VERHALTENSMEDIZINISC Goebel G, 1998, TINNITUS FRAGEBOGEN Hesse G, 2001, HNO, V49, P764, DOI 10.1007/s001060170052 HILLER W, 2005, BEHAV RES THER, V43, P959 JASTREBOFF PJ, 1990, NEUROSCI RES, V8, P221, DOI 10.1016/0168-0102(90)90031-9 JUNGE L, 2005, THESIS KONZAG TA, 2005, HNO ONLINE FIRST KORDY H, 2000, DIAGNOSTIK PSYCHOTHE, P477 Muhlnickel W, 1998, P NATL ACAD SCI USA, V95, P10340, DOI 10.1073/pnas.95.17.10340 Pilgramm M, 1999, P 6 INT TINN SEM CAM, P64 Salvi R. J., 2000, TINNITUS HDB, P123 Schmidt A, 2004, HNO, V52, P242, DOI 10.1007/s00106-003-0960-y Seifert K, 2005, HNO, V53, P364, DOI 10.1007/s00106-004-1208-8 Sirois FM, 2006, HEALTH PSYCHOL, V25, P119, DOI 10.1037/0278-6133.25.1.119 Stobik C, 2003, PSYCHOTHER PSYCH MED, V53, P344 von Wedel H, 2000, HNO, V48, P887, DOI 10.1007/s001060050685 WEISZ N, 2004, BMC NEUROSCI, V5 ZACHRIAT C, 2003, VERGLEICHENDE EVALUA Zenner HP, 2003, HNO, V51, P687, DOI 10.1007/s00106-003-0939-2 Zenner HP, 1998, HNO, V46, P699, DOI 10.1007/s001060050299 NR 29 TC 3 Z9 4 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013 USA SN 0017-6192 J9 HNO JI HNO PD MAY PY 2007 VL 55 IS 5 BP 375 EP + DI 10.1007/s00106-006-1478-4 PG 8 WC Otorhinolaryngology SC Otorhinolaryngology GA 166CI UT WOS:000246354400008 PM 17082957 ER PT J AU Stevens, C Walker, G Boyer, M Gallagher, M AF Stevens, Catherine Walker, Gary Boyer, Morten Gallagher, Melinda TI Severe tinnitus and its effect on selective and divided attention SO INTERNATIONAL JOURNAL OF AUDIOLOGY LA Spanish DT Article DE tinnitus; selective attention; dual task; anxiety; depression; hearing loss ID HEARING-LOSS; SUFFERERS; DISTRESS; PERFORMANCE; PREDICTION; EFFICIENCY; DISORDERS; ANXIETY AB The effect of chronic, severe tinnitus on two visual tasks was investigated. A general depletion of resources hypothesis states that overall performance would be impaired in a tinnitus group relative to a control group whereas a controlled processing hypothesis states that only tasks that are demanding, requiring strategic processes, are affected. Eleven participants who had experienced severe tinnitus for more than two years comprised the tinnitus group. A control group was matched for age and verbal IQ. Levels of anxiety, depression, and high frequency average hearing level were treated as covariates. Tasks consisted of the say-word (easy) and say-color (demanding) conditions of the Stroop task, a single (baseline) reaction time (RT) task, and dual tasks involving word reading or category naming while performing a concurrent RT task. Results supported the general depletion of resources hypothesis: RT of the tinnitus group was slower in both conditions of the Stroop task, and in the word reading and category naming conditions of the dual task. Differences were not attributable to high frequency average hearing level, anxiety, or depression. C1 Univ Western Sydney Bankstown, MARCS Auditory Labs, Penrith, NSW 1797, Australia. RP Stevens, C (reprint author), Univ Western Sydney Bankstown, MARCS Auditory Labs, Locked Bag 1797, Penrith, NSW 1797, Australia. EM kj.stevens@uws.edu.au RI Stevens, Catherine/D-9948-2012 CR Andersson G, 2000, J SPEECH LANG HEAR R, V43, P1168 Andersson G, 2003, PSYCHOL HEALTH, V18, P667, DOI 10.1080/0887044031000112100 ANDERSSON G, 2002, P 7 INT TINN SEM FRE, P197 Andersson G, 2002, CLIN OTOLARYNGOL, V27, P270, DOI 10.1046/j.1365-2273.2002.00581.x Andersson Gerhard, 2000, Scandinavian Journal of Behaviour Therapy, V29, P57 Andersson G, 2005, CYBERPSYCHOL BEHAV, V8, P32, DOI 10.1089/cpb.2005.8.32 Beck A. 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I., 1975, ATTENTION PERFORMANC, VV Rossing P, 2006, DIABETOLOGIA, V49, P11, DOI 10.1007/s00125-005-0077-3 Rutter DR, 1999, PSYCHOL HEALTH, V14, P711, DOI 10.1080/08870449908410759 SPIELBERGER CD, 1983, MANUAL STATE TRAIT A Tyler MD, 2005, BEHAV RES METHODS, V37, P139, DOI 10.3758/BF03206408 TYLER RS, 1983, J SPEECH HEAR DISORD, V48, P150 VANROOIJ JCGM, 1990, J ACOUST SOC AM, V88, P2611, DOI 10.1121/1.399981 Vesterager V, 1997, BRIT MED J, V314, P728 WILSON PH, 1991, J SPEECH HEAR RES, V34, P197 Zenner HP, 2004, ACTA OTO-LARYNGOL, V124, P436, DOI 10.1080/00016480410016333 NR 45 TC 38 Z9 41 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 1499-2027 J9 INT J AUDIOL JI Int. J. Audiol. PD MAY PY 2007 VL 46 IS 5 BP 208 EP 216 DI 10.1080/14992020601102329 PG 9 WC Audiology & Speech-Language Pathology; Otorhinolaryngology SC Audiology & Speech-Language Pathology; Otorhinolaryngology GA 178YC UT WOS:000247255300002 PM 17487668 ER PT J AU Baracca, GN Forti, S Crocetti, A Fagnani, E Scotti, A Del Bo, L Ambrosetti, U AF Baracca, Giovanna N. Forti, Stella Crocetti, Andrea Fagnani, Enrico Scotti, Alberto Del Bo, Luca Ambrosetti, Umberto TI Results of TRT after eighteen months: Our experience SO INTERNATIONAL JOURNAL OF AUDIOLOGY LA English DT Article DE tinnitus; neurophysiological model; tinnitus retraining therapy; counselling; sound therapy ID TINNITUS HANDICAP QUESTIONNAIRE; PREVALENCE; MODEL; MECHANISMS; MANAGEMENT; HEARING AB The aim of this study was to evaluate the efficacy of TRT in patients suffering from tinnitus. The tinnitus disorder affects about 10-15% of the population and, in one person out of a hundred, it is a disabling disorder. TRT treatment is based on Jastreboff's neurophysio logical model. TRT consists of two parts: counselling, and sound therapy by means of dedicated hearing aids and sound generators. It proved to be useful to reduce the symptoms related to tinnitus. Jastreboff's structured interviews were proposed to a sample of 51 patients with tinnitus belonging to the I-II-III-IV classes according to Jastreb-off. These patients were treated for IS months. Sixty-eight percent of patients reported a reduction in the symptoms related to tinnitus, such as sleep disturbance, problems in concentration, and inability to relax. A percentage (64.7%) of patients thought that their quality of life was improved. Patients who had suffered from tinnitus for less than one year achieved significantly better results than patients who had suffered for a longer period of time. TRT is an effective tool in the treatment of tinnitus. C1 Osped Maggiore, UO Complessa Orlaudiol, Fdn IRCCS, Policlin, I-20100 Milan, Italy. Fdn Osped Policlin, IRCCS, Mol & Genet Epidemiol Unit, Milan, Italy. Del Bo Tecnol Ascolto, Milan, Italy. Osped San Paolo, Milan, Italy. RP Baracca, GN (reprint author), Osped Maggiore, UO Complessa Orlaudiol, Fdn IRCCS, Policlin, I-20100 Milan, Italy. EM baracca.giovanna@libero.it CR Bartnik G, 1999, P 6 INT TINN SEM 199, P415 Brown MC, 1999, FUNDAMENTAL NEUROSCI, P791 Coles R. R. 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J. Audiol. PD MAY PY 2007 VL 46 IS 5 BP 217 EP 222 DI 10.1080/14992020601175945 PG 6 WC Audiology & Speech-Language Pathology; Otorhinolaryngology SC Audiology & Speech-Language Pathology; Otorhinolaryngology GA 178YC UT WOS:000247255300003 PM 17487669 ER PT J AU Santos, L Morata, TC Jacob, LC Albizu, E Marques, JM Paini, M AF Santos, Lorayne Morata, Thais C. Jacob, Lilian C. Albizu, Evelyn Marques, Jair M. Paini, Michele TI Music exposure and audiological findings in Brazilian disc jockeys (DJs) SO INTERNATIONAL JOURNAL OF AUDIOLOGY LA English DT Article; Proceedings Paper CT 34th International Congress on Noise Control Engineering (INTERNOISE 2005) CY AUG 06-10, 2005 CL Rio de Janeiro, BRAZIL DE sound pressure levels; otoacoustic emissions; hearing loss; tinnitus; pure-tone audiometry; temporary threshold shift; music-induced hearing loss ID INDUCED HEARING-LOSS; TEMPORARY THRESHOLD SHIFT; OTOACOUSTIC EMISSIONS; ACOUSTIC DISTORTION; AMPLIFIED MUSIC; EQUAL ENERGY; NOISE; DISCOTHEQUES; EMPLOYEES AB The aim of this study was to examine the music exposure and hearing of disc jockeys (DJs). We conducted personal noise dosimetry on 30 DJs and interviewed them regarding their hearing and their job. We conducted pure-tone audiometry, and transient and distortion product otoacoustic emissions before their exposure to music during their work. This First test was preceded by a period of at least 12 hours without exposure to music or noise. We repeated the pure-tone audiometry and otoacoustic emissions after their music exposure, and poorer performances were registered in all retests. The nightclubs' average sound level ranged between 93.2 to 109.7 dB(A). Statistical analysis showed significant bilateral temporary threshold shifts at all frequencies between audiometry performed pre- and post-exposure to amplified music. Transient otoacoustic emissions showed a significant difference in bilateral amplitude and reproducibility at all frequency bands tested. The comparison of distortion product otoacoustic emissions results pre- and post-music exposure showed there was a significant difference in amplitude. Music exposure was associated with temporary and permanent auditory dysfunction among professional DJs. C1 NIOSH, Hearing Loss Prevent Team, DART, Cincinnati, OH 45226 USA. FUNDACENTRO, Minist Trabalho & Emprego, Curitiba, Parana, Brazil. RP Morata, TC (reprint author), NIOSH, Hearing Loss Prevent Team, DART, C27,4676 Columbia Pkwy, Cincinnati, OH 45226 USA. EM tmorata@cdc.gov RI Morata, Thais/A-6848-2009; Jacob-Corteletti , Lilian Cassia /I-9391-2012 CR American National Standards Institute, 1991, S311991 ANSI ANDRIJAUSKAS S, 2003, DIST COMUNICACAO, V14, P413 Avan P, 2005, HEARING RES, V209, P68, DOI 10.1016/j.heares.2005.06.008 AVAN P, 1995, J ACOUST SOC AM, V97, P3012, DOI 10.1121/1.411866 AXELSSON A, 1995, OCCUP MED, V10, P657 AXELSSON A, 1981, EAR HEARING, V2, P64, DOI 10.1097/00003446-198103000-00002 AXELSSON A, 1978, ACTA OTO-LARYNGOL, V85, P225, DOI 10.3109/00016487809111929 Axelsson A, 1981, Acta Otolaryngol Suppl, V377, P3 BALATSOURAS DG, 2004, MED SCI MONITOR, V10, P218 BOGOCH II, 2005, CAN J PUB HLTH, V96, P73 Bray A, 2004, J LARYNGOL OTOL, V118, P123 GORGA MP, 1993, J ACOUST SOC AM, V93, P2050, DOI 10.1121/1.406691 Gunderson E, 1997, AM J IND MED, V31, P75 Hellstrom PA, 1998, SCAND AUDIOL, V27, P87 *ISO, 1991, 3891964 ISO JERGER J, 1970, ARCH OTOLARYNGOL, V36, P61 Kahari K, 2003, INT J AUDIOL, V42, P279, DOI 10.3109/14992020309078347 KEMP DT, 1978, J ACOUST SOC AM, V64, P1386, DOI 10.1121/1.382104 Kemp DT, 2002, BRIT MED BULL, V63, P223, DOI 10.1093/bmb/63.1.223 Laitinen H, 2005, Noise Health, V7, P21 Lee L. T., 1999, SMJ, V40, P571 Liebel J, 1996, LARYNGO RHINO OTOL, V75, P259, DOI 10.1055/s-2007-997575 LINDGREN F, 1983, EAR HEARING, V4, P197, DOI 10.1097/00003446-198307000-00004 LONSBURYMARTIN BL, 1987, HEARING RES, V28, P173, DOI 10.1016/0378-5955(87)90048-7 Mansfield JD, 1999, BRIT J AUDIOL, V33, P211 MARCONPANIZ SI, 2005, CAMINHOS SAUDE AUDIT, P28 MCMILLAN R, 2000, NOISE CONTROL MUSIC MENDES MH, 2006, 35 INT C EXP NOIS CO MeyerBisch C, 1996, AUDIOLOGY, V35, P121 Prasher D, 1999, Int J Occup Med Environ Health, V12, P183 Sadhra S, 2002, ANN OCCUP HYG, V46, P455, DOI 10.1093/annhyg/mef051 SCHMIEDT RA, 1986, J ACOUST SOC AM, V79, P1481, DOI 10.1121/1.393675 Schmuziger N, 2006, EAR HEARING, V27, P321, DOI 10.1097/01.aud.0000224737.34907.5e Silveira JAM, 2001, REV BRAS OTORINOLARI, V67, P650 SISNANDO MSM, 2002, REV FONO ATUAL, V5, P10 SWANSON SJ, 1987, EAR HEARING, V8, P288, DOI 10.1097/00003446-198710000-00006 TAN TC, 1990, IND HEALTH, V28, P37 VANSIN R, 2002, REV CEFAC, V4, P219 YAHN C, 2003, VLUME SUPERALTO NOS NR 39 TC 10 Z9 12 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 1499-2027 J9 INT J AUDIOL JI Int. J. Audiol. PD MAY PY 2007 VL 46 IS 5 BP 223 EP 231 DI 10.1080/14992020601188575 PG 9 WC Audiology & Speech-Language Pathology; Otorhinolaryngology SC Audiology & Speech-Language Pathology; Otorhinolaryngology GA 178YC UT WOS:000247255300004 PM 17487670 ER PT J AU Daniel, E AF Daniel, Eileen TI Noise and hearing loss: A review SO JOURNAL OF SCHOOL HEALTH LA English DT Review DE noise-induced hearing loss; hearing protection; hearing conservation; tinnitus ID TEMPORARY THRESHOLD SHIFT; LONG-TERM; AGE; EXPOSURE; ASSOCIATION; PREVALENCE; CHILDREN; SMOKING; HEALTH AB BACKGROUND: Noise-induced hearing loss is a major cause of deafness and hearing impairment in the United States. Though genetics and advanced age are major risk factors, temporary and permanent hearing impairments are becoming more common among young adults and children especially with the increased exposure to portable music players. Though treatment options are limited for most people with noise-related hearing loss, several modifiable health behaviors that should begin in childhood might prevent or delay the onset of hearing impairment. The purpose of this article is to review modifiable and nonmodifiable risk factors, comorbidity, and the role of health education in the prevention of noise-induced hearing loss. METHODS: Review of current literature in the etiology, prevention, and treatment of noise-induced hearing loss as well as the role of health education. RESULTS: Nonmodifiable risk factors related to noise-related hearing loss include increasing age, genetics, male gender, and race. Modifiable risk factors are voluntary exposure to loud noise, nonuse of hearing protection, smoking, lack of exercise, poor diet, tooth loss, and the presence of diabetes and cardiovascular disease. CONCLUSIONS: As hearing impairment among children and teenagers rises due to mostly voluntary exposure to loud noise, there are many implications for health education. Health educators need to address barriers to the use of hearing protection, deliberate exposure to loud music, and other modifiable risk factors, which cause and exacerbate hearing loss among those exposed to loud noise. C1 SUNY Coll Brockport, Dept Hlth Sci, Brockport, NY 14420 USA. RP Daniel, E (reprint author), SUNY Coll Brockport, Dept Hlth Sci, Brockport, NY 14420 USA. EM edaniel@brockport.edu RI Legarth, Jonas/A-9156-2012 CR Arlinger S., 2003, INT J AUDIOL, V42, P17, DOI DOI 10.3109/14992020309074639 Attias J, 2004, CLIN OTOLARYNGOL, V29, P635, DOI 10.1111/j.1365-2273.2004.00866.x Barrenas ML, 2005, HEARING RES, V205, P123, DOI 10.1016/j.heares.2005.03.019 Bogoch II, 2005, CAN J PUBLIC HEALTH, V96, P69 Borchgrevink H M, 2003, Noise Health, V5, P25 BORNZAFT A, 1996, NUTR HLTH REV, V78, P2 CDC (Centers for Disease Control and Prevention), 1998, CRIT REC STAND OCC N Chung JH, 2005, PEDIATRICS, V115, P861, DOI 10.1542/peds.2004-0173 Cristell M, 1998, SCAND AUDIOL, V27, P219, DOI 10.1080/010503998420522 Cruickshanks KJ, 1998, JAMA-J AM MED ASSOC, V279, P1715, DOI 10.1001/jama.279.21.1715 de Leon-Morales LVD, 2005, ARCH MED RES, V36, P507, DOI 10.1016/j.arcmed.2005.02.002 Dogru H, 2003, ACTA OTO-LARYNGOL, V123, P941, DOI 10.1080/00016480310000746 Ferrite S, 2005, OCCUP MED-OXFORD, V55, P48, DOI 10.1093/occmed/kqi002 Folmer RL, 2002, J SCHOOL HEALTH, V72, P51 Helzner EP, 2005, J AM GERIATR SOC, V53, P2119, DOI 10.1111/j.1532-5415.2005.00525.x Holgers K-M, 2005, Noise Health, V7, P27 Houston DK, 1999, AM J CLIN NUTR, V69, P564 Ishii EK, 1998, J OCCUP ENVIRON MED, V40, P661, DOI 10.1097/00043764-199808000-00001 KAGEYAMA T, 1999, PERCEPT MOTOR SKILL, V88, P423 Kakarlapudi V, 2003, OTOL NEUROTOL, V24, P382, DOI 10.1097/00129492-200305000-00006 Kaygusuz I, 2001, HEARING RES, V162, P43, DOI 10.1016/S0378-5955(01)00365-3 Klein BEK, 2001, AM J OPHTHALMOL, V132, P537, DOI 10.1016/S0002-9394(01)01126-6 Kolkhorst FW, 1998, MED SCI SPORT EXER, V30, P289, DOI 10.1097/00005768-199802000-00018 Kopke R, 2005, ACTA OTO-LARYNGOL, V125, P235, DOI 10.1080/00016480410023038 Lawrence H P, 2001, Spec Care Dentist, V21, P129, DOI 10.1111/j.1754-4505.2001.tb00242.x Lusk SL, 2002, ARCH ENVIRON HEALTH, V57, P273 Mercier V., 2002, NOISE HEALTH, V4, P47 MIZOUE T, 2003, J OCCUP ENVIRON MED, V60, P56 Niskar AS, 2001, PEDIATRICS, V108, P40, DOI 10.1542/peds.108.1.40 OLSEN WSE, 2004, NOISE HEALTH, V7, P59 Peters R J, 2003, Noise Health, V5, P47 Scheibe F, 2001, NOISE HLTH, V3, P79 Schell C L, 1999, Spec Care Dentist, V19, P208, DOI 10.1111/j.1754-4505.1999.tb01387.x Schmuziger N, 2006, INT J AUDIOL, V45, P46, DOI 10.1080/14992020500377089 Serra MR, 2005, INT J AUDIOL, V44, P65, DOI 10.1080/14992020400030010 Strecher VJ, 1997, HLTH BEHAV HLTH ED T, P41 Torre P, 2005, J SPEECH LANG HEAR R, V48, P473, DOI 10.1044/1092-4388(2005/032) NR 37 TC 76 Z9 84 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 0022-4391 J9 J SCHOOL HEALTH JI J. Sch. Health PD MAY PY 2007 VL 77 IS 5 BP 225 EP 231 DI 10.1111/j.1746-1561.2007.00197.x PG 7 WC Education & Educational Research; Education, Scientific Disciplines; Health Care Sciences & Services; Public, Environmental & Occupational Health SC Education & Educational Research; Health Care Sciences & Services; Public, Environmental & Occupational Health GA 159UM UT WOS:000245893100004 PM 17430434 ER PT J AU Steiger AF Steiger TI Assessment of objective pulsatile tinnitus in a patient with syringohydromyelia SO JOURNAL OF THE AMERICAN ACADEMY OF AUDIOLOGY LA English DT Correction CR STEIGER, 2007, ASSESSMENT OF OBJECT, V18, P200 NR 1 TC 0 Z9 0 PU AMER ACAD AUDIOLOGY PI RESTON PA 11730 PLAZA DR, STE 300, RESTON, VA 20190 USA SN 1050-0545 J9 J AM ACAD AUDIOL JI J. Am. Acad. Audiol. PD MAY PY 2007 VL 18 IS 5 BP 454 EP 454 PG 1 WC Audiology & Speech-Language Pathology; Otorhinolaryngology SC Audiology & Speech-Language Pathology; Otorhinolaryngology GA 191ON UT WOS:000248140800010 ER PT J AU Wiermann, A Galambos, P Vafiadis, J Wagenfeld, L Richard, G Klemm, M Zeitz, O AF Wiermann, A. Galambos, P. Vafiadis, J. Wagenfeld, L. Richard, G. Klemm, M. Zeitz, O. TI Retrobulbar haemodynamics in normal and high tension glaucoma patients: the diagnostic importance of tinnitus, migraine and Raynaud-like symptoms SO KLINISCHE MONATSBLATTER FUR AUGENHEILKUNDE LA German DT Article DE glaucoma; colour Doppler imaging; microperfusion ID OPEN-ANGLE GLAUCOMA; OCULAR BLOOD-FLOW; INTRAOCULAR-PRESSURE; AUTOREGULATION; CIRCULATION; PROGRESSION; VELOCITIES; VESSELS; DAMAGE AB Background: In the pathophysiology of open-angle glaucoma altered perfusion of the optic nerve head is of importance. Up to now these disturbances were presumed to be the chief cause of glaucomatous damage in patients with normal tension glaucoma showing other vascular disturbances like migraine or tinnitus. Patients and Methods: Peak systolic velocity (PSV) and end-diastolic velocity (EDV) were measured and the resistive index (RI) was calculated by colour Doppler imaging (CDI) in the ophthalmic artery (OA), central retinal artery (CRA) and in the short and long posterior ciliary arteries (SPCA, LPCA) in 18 patients with normal tension glaucoma (NTG), in 18 patients with high tension glaucoma (HTG) and in 18 normal control subjects. Results: In an upright sitting position both glaucoma groups showed statistically significant decreases in PSV and EDV in CRA and SPCA compared to the control subjects. HTG when compared to NTG and normal subjects showed statistically significant decreases of EDV and statistically significant increases of RI in LPCA. In addition, compared to normal subjects, HTG patients showed statistically significant increases of RI in both OA and SPCA. Discussion: Both glaucoma groups showed decreased blood flow velocities in the small retrobulbar vessels in an upright sitting position. Normal tension glaucoma patients with symptoms of vasospasms compared to patients with high tension glaucoma showed only small differences in ocular haemodynamics. C1 Univ Klinikum Hamburg Eppendorf, Klin & Poliklin Augenheilkunde, D-20246 Hamburg, Germany. RP Wiermann, A (reprint author), Univ Klinikum Hamburg Eppendorf, Klin & Poliklin Augenheilkunde, Martinistr 52, D-20246 Hamburg, Germany. EM a.wiermann@uke.uni-hamburg.de CR Breil P, 2002, OPHTHALMOLOGE, V99, P613, DOI 10.1007/s00347-001-0601-x Butt Z, 1997, INVEST OPHTH VIS SCI, V38, P690 Emre M, 2004, BRIT J OPHTHALMOL, V88, P662, DOI 10.1136/bjo.2003.032110 Evans DW, 1999, BRIT J OPHTHALMOL, V83, P809, DOI 10.1136/bjo.83.7.809 GALASSI F, 1994, OPHTHALMOLOGICA, V208, P304 Galassi F, 2003, ARCH OPHTHALMOL-CHIC, V121, P1711, DOI 10.1001/archopht.121.12.1711 Gherghel D, 2004, INVEST OPHTH VIS SCI, V45, P3546, DOI 10.1167/iovs.04-0290 Gherghel D, 2000, AM J OPHTHALMOL, V130, P597, DOI 10.1016/S0002-9394(00)00766-2 HARRIS A, 1994, AM J OPHTHALMOL, V118, P642 Harris Alon, 2005, Ophthalmol Clin North Am, V18, P345, DOI 10.1016/j.ohc.2005.04.001 HAYREH SS, 1970, BRIT J OPHTHALMOL, V54, P461, DOI 10.1136/bjo.54.7.461 Kaiser HJ, 1997, AM J OPHTHALMOL, V123, P320 KLEWS P, 1993, FARBKODIERTE DUPLEXS, P1 Liu CJ, 1999, ACTA OPHTHALMOL SCAN, V77, P658, DOI 10.1034/j.1600-0420.1999.770610.x Nicolela MT, 1996, AM J OPHTHALMOL, V121, P502 RANKIN SJA, 1995, AM J OPHTHALMOL, V119, P685 Satilmis M, 2003, AM J OPHTHALMOL, V135, P664, DOI 10.1016/S0002-9394(02)02156-6 SCHMIDT KG, 2000, FORTBILDUNG GLAUKOM, V3, P103 Schumann J, 2000, AM J OPHTHALMOL, V129, P728, DOI 10.1016/S0002-9394(99)00481-X SPENCER JAD, 1991, J ULTRAS MED, V10, P305 Tutaj M, 2004, J NEUROL SCI, V220, P49, DOI 10.1016/j.jns.2004.02.002 Zhao DY, 2000, EYE, V14, P445 NR 22 TC 2 Z9 3 PU GEORG THIEME VERLAG KG PI STUTTGART PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY SN 0023-2165 J9 KLIN MONATSBL AUGENH JI Klinische Monatsblat. Augenheilkunde PD MAY PY 2007 VL 224 IS 5 BP 396 EP 400 DI 10.1055/s-2007-963118 PG 5 WC Ophthalmology SC Ophthalmology GA 170JB UT WOS:000246658300002 PM 17516368 ER PT J AU Lipman, RI Lipman, SP AF Lipman, Ruthann I. Lipman, Sidney P. TI Phase-shift treatment for predominant tone tinnitus SO OTOLARYNGOLOGY-HEAD AND NECK SURGERY LA English DT Article AB OBJECTIVES: To independently evaluate phase-shift treatment for predominant tone tinnitus. STUDY DESIGN: Prospective, single-blinded crossover study. METHODS: 61 Subjects with predominant tone tinnitus participated in 2 weeks of control and 2 weeks of phase-shift treatment. Frequency and intensity matching, pre- and post-treatment tinnitus handicap inventory (THI) scores, and patient diaries were outcome measures. RESULTS: Initial volume comparisons show a strong relationship between treatment and decrease in tinnitus intensity, with 57% of patients achieving successful treatment. Thirty-seven percent decreased by one THI grade, 5% by two. Utilizing patient diaries, 42% of patients reported periods of complete residual inhibition (CRI) ranging from 1 hour to 7 days (average 2 days). No periods of CRI were reported in control weeks. CONCLUSION: Phase-shift treatment significantly benefited the majority Of our patients. These outcomes suggest that this device may be a valuable tool. Further long-term studies with home therapy are warranted. (C) 2007 American Academy of Otolaryngology-Head and Neck Surgery Foundation. All rights reserved. RP Lipman, RI (reprint author), ENT Specialists NW PA, 3580 Peach St, Erie, PA 16508 USA. EM ruthann.lipman@gmail.com CR Andersson G, 2004, J CLIN PSYCHOL, V60, P171, DOI 10.1002/jclp.10243 CHOY D, 2004, NEW YORK AC MED S NE Dobie RA, 2003, OTOLARYNG CLIN N AM, V36, P383, DOI 10.1016/S0030-6665(02)00168-8 Ghossaini SN, 2004, LARYNGOSCOPE, V114, P495, DOI 10.1097/00005537-200403000-00020 Goldstein Barbara A, 2005, Int Tinnitus J, V11, P14 Henry JA, 2004, J REHABIL RES DEV, V41, P121, DOI 10.1682/JRRD.2004.02.0121 Henry James A, 2002, J Am Acad Audiol, V13, P559 HUMES LE, 1985, HDB CLIN AUDIOLOGY, P94 Jastreboff P. J., 1995, MECH TINNITUS, P73 Jastreboff P J, 2000, J Am Acad Audiol, V11, P162 López-González Miguel A, 2004, Int Tinnitus J, V10, P150 Newman CW, 1996, ARCH OTOLARYNGOL, V122, P143 Newman C W, 1998, J Am Acad Audiol, V9, P153 NOIK E, 2005, EUR FED AUD SOC GOTH Rossiter S, 2006, J SPEECH LANG HEAR R, V49, P150, DOI 10.1044/1092-4388(2006/012) Stephens SDG, 1987, TINNITUS, P1 Vernon J, 1987, TINNITUS, P71 Vernon J-A, 2000, TINNITUS HDB, P313 Vernon JA, 2003, OTOLARYNG CLIN N AM, V36, P307, DOI 10.1016/S0030-6665(02)00163-9 NR 19 TC 8 Z9 8 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0194-5998 J9 OTOLARYNG HEAD NECK JI Otolaryngol. Head Neck Surg. PD MAY PY 2007 VL 136 IS 5 BP 763 EP 768 DI 10.1016/j.otohns.2006.10.046 PG 6 WC Otorhinolaryngology; Surgery SC Otorhinolaryngology; Surgery GA 164QB UT WOS:000246247600016 PM 17478212 ER PT J AU Kan, P Stevens, EA Warner, J Couldwell, WT AF Kan, Peter Stevens, Edwin A. Warner, Judith Couldwell, William T. TI Resolution of an anterior-inferior cerebellar artery feeding aneurysm with the treatment of a transverse-sigmoid dural arteriovenous fistula SO SKULL BASE-AN INTERDISCIPLINARY APPROACH LA English DT Article DE aneurysms; dural arteriovenous fistulas; endovascular therapy; surgery ID INTRACRANIAL ANEURYSMS; MALFORMATIONS; HEMORRHAGE; SINUS AB A 27-year-old man developed an unruptured anterior-inferior cerebellar artery (ATCA) feeding aneurysm from a transverse- sigmoid dural arteriovenous malformation. The patient, with a known history of left transverse and sigmold sinus thrombosis, presented with pulse-synchronous. tinnitus. Angiography revealed an extensive dural arteriovenous fistula (AVF), with feeders from both the extracranial and intracranial circulations, involving the right transverse sinus, the torcula, and the left transverse/sigmoid sinuses. Multimodal endovascular and open surgical therapy was used to manage the lesion. Before a planned second-stage treatment for the left sigmoid sinus component, the dural AVF improved significantly. During this interval, however, a small flow-related aneurysm developed on the left AICA feeding the petrous dural region. The aneurysm resolved after resection of the involved sigmoid sinus. This is the first reported case of an unruptured feeding-artery aneurysm in an intracranial dural AVF that resolved spontaneously with treatment of the dural AVF. Until more is known about the natural history, the decisions of when and whether to treat an unruptured dural AVF feeding-artery aneurysm must be made on an individual basis. C1 Univ Utah, Sch Med, Dept Neurosurg, Salt Lake City, UT 84132 USA. Univ Utah, Sch Med, Dept Radiol, Salt Lake City, UT 84132 USA. Univ Utah, Sch Med, Dept Ophthalmol, Salt Lake City, UT 84132 USA. RP Couldwell, WT (reprint author), Univ Utah, Sch Med, Dept Neurosurg, 175 N Med Dr, Salt Lake City, UT 84132 USA. EM william.couldwell@hsc.utah.edu CR BATJER H, 1986, NEUROSURGERY, V18, P29 BROWN RD, 1990, J NEUROSURG, V73, P859, DOI 10.3171/jns.1990.73.6.0859 CASTAIGNE P, 1975, ANN MED INTERNE, V126, P813 CHAUDHARY MY, 1982, AM J NEURORADIOL, V3, P13 DJINDJIA.R, 1973, NEURORADIOLOGY, V6, P20 Finn Michael, 2007, Neurosurg Focus, V22, pEditorial Friedman DI, 2004, NEUROLOGY, V62, P2297 GACS G, 1983, J NEUROSURG, V58, P63, DOI 10.3171/jns.1983.58.1.0063 HOUSER OW, 1972, RADIOLOGY, V105, P55 KAECH D, 1987, NEUROSURGERY, V21, P575 Koch C, 2004, J NEUROSURG, V100, P385, DOI 10.3171/spi.2004.100.4.0385 KUTLUK K, 1991, NEUROCHIRURGIA, V34, P144 LALWANI AK, 1993, J NEUROSURG, V79, P11, DOI 10.3171/jns.1993.79.1.0011 LASJAUNIAS P, 1988, ACTA NEUROCHIR, V91, P29, DOI 10.1007/BF01400524 Lawton MT, 1997, J NEUROSURG, V87, P267, DOI 10.3171/jns.1997.87.2.0267 Malek AM, 1999, NEUROSURGERY, V44, P877, DOI 10.1097/00006123-199904000-00114 Malek AM, 2000, NEUROSURG CLIN N AM, V11, P147 OKAMOTO S, 1984, SURG NEUROL, V22, P335, DOI 10.1016/0090-3019(84)90135-6 PERRET G, 1966, J NEUROSURG, V25, P467, DOI 10.3171/jns.1966.25.4.0467 Redekop G, 1998, J NEUROSURG, V89, P539, DOI 10.3171/jns.1998.89.4.0539 Stapf C, 2002, J NEUROL NEUROSUR PS, V73, P294, DOI 10.1136/jnnp.73.3.294 Thompson RC, 1998, NEUROSURGERY, V43, P202, DOI 10.1097/00006123-199808000-00006 Touho Hajime, 1994, Neurologia Medico-Chirurgica, V34, P543, DOI 10.2176/nmc.34.543 Westphal M, 2000, J NEUROSURG, V92, P995, DOI 10.3171/jns.2000.92.6.0995 NR 24 TC 3 Z9 3 PU THIEME MEDICAL PUBL INC PI NEW YORK PA 333 SEVENTH AVE, NEW YORK, NY 10001 USA SN 1531-5010 J9 SKULL BASE-INTERD AP JI Skull Base-Interdiscip. Appr. PD MAY PY 2007 VL 17 IS 3 BP 205 EP 209 DI 10.1055/s-2007-970559 PG 5 WC Clinical Neurology; Otorhinolaryngology; Surgery SC Neurosciences & Neurology; Otorhinolaryngology; Surgery GA 171OJ UT WOS:000246745000010 PM 17973034 ER PT J AU Astner, ST Nieder, C Stock, K Gaa, J Grosu, AL AF Astner, Sabrina T. Nieder, Carsten Stock, Konrad Gaa, Jochen Grosu, Anca Ligia TI Carcinomatous meningitis appearing as acoustic neuromas - Two cases SO STRAHLENTHERAPIE UND ONKOLOGIE LA English DT Article DE acoustic neuroma; bilateral acoustic neuroma; hearing loss; carcinomatous meningitis; stereotactic radiotherapy; radiosurgery ID CEREBELLOPONTINE ANGLE TUMORS; STEREOTACTIC RADIOSURGERY; RADIOTHERAPY AB Background: For acoustic neuromas, stereotactic radiotherapy (radiosurgery or stereotactic fractionated radiotherapy) has been established as an important alternative to microsurgery. In most cases initial symptoms are slow progression of unilateral hearing loss, tinnitus or vertigo or acute hearing loss with vertigo. MRI scan shows a contrast-enhancing tumor within the inner auditory channel. If the patient undergoes primary radiotherapy, diagnosis is usually not verified histologically. Therefore, careful evaluation of the medical history is mandatory despite a typical appearance on the MRI scan. If medical history does not match with acoustic neuroma, further diagnostics are necessary to rule out infectious disease or carcinomatous meningitis. Case Report: Two patients with hearing loss, vertigo and the diagnosis of acoustic neuromas by MRI scan were referred for radiotherapy. In both cases the symptoms progressed very rapidly, not typical of acoustic neuromas, and in both patients repeated liquor puncture finally revealed carcinomatous meningitis. One patient died during therapy; in the second patient intrathecal chemotherapy and additional radiotherapy of the skull base led to partial remission continuing for several months. Conclusion: Before primary radiotherapy of small intrameatal lesions diagnosis must be reassessed carefully. This is especially true for bilateral lesions suspicious for acoustic neuromas and rapid progression and persistence of clinical symptoms where carcinomatous meningitis has to be taken into account. C1 Tech Univ Munich, Klinikum Isar, Dept Radiat Oncol, D-81675 Munich, Germany. Tech Univ Munich, Dept Internal Med, D-8000 Munich, Germany. Tech Univ Munich, Dept Radiol, D-8000 Munich, Germany. RP Astner, ST (reprint author), Tech Univ Munich, Klinikum Isar, Dept Radiat Oncol, Ismaninger Str 22, D-81675 Munich, Germany. EM sabrina.astner@gmx.de CR BALDWIN D, 1991, J NEUROSURG, V74, P910, DOI 10.3171/jns.1991.74.6.0910 Bottke D, 2005, STRAHLENTHER ONKOL, V181, P251, DOI 10.1007/s00066-005-1336-4 Combs SE, 2006, INT J RADIAT ONCOL, V64, P1341, DOI 10.1016/j.ijrobp.2005.10.024 Cozzi L, 2006, STRAHLENTHER ONKOL, V182, P376, DOI 10.1007/s00066-006-1500-5 Ernst-Stecken A, 2005, STRAHLENTHER ONKOL, V181, P336, DOI 10.1007/s00066-005-1371-1 Halleck P, 2006, HNO, V54, P553, DOI 10.1007/s00106-005-1317-z Hermann B, 2001, STRAHLENTHER ONKOL, V177, P195, DOI 10.1007/PL00002398 Huang TW, 2002, OTOL NEUROTOL, V23, P975, DOI 10.1097/00129492-200211000-00027 Lee WT, 2005, OTOLARYNG HEAD NECK, V132, P505, DOI 10.1016/j.otohns.2004.05.004 LHUILLIER FM, 1992, NEURORADIOLOGY, V34, P144 Raut VV, 2004, CLIN OTOLARYNGOL, V29, P505, DOI 10.1111/j.1365-2273.2004.00852.x Trott KR, 2006, STRAHLENTHER ONKOL, V182, P431, DOI 10.1007/s00066-006-1542-8 NR 12 TC 1 Z9 1 PU URBAN & VOGEL PI MUNICH PA NEUMARKTER STRASSE 43, D-81673 MUNICH, GERMANY SN 0179-7158 J9 STRAHLENTHER ONKOL JI Strahlenther. Onkol. PD MAY PY 2007 VL 183 IS 5 BP 279 EP 283 DI 10.1007/s00066-007-1615-3 PG 5 WC Oncology; Radiology, Nuclear Medicine & Medical Imaging SC Oncology; Radiology, Nuclear Medicine & Medical Imaging GA 167JE UT WOS:000246447200008 PM 17497100 ER PT J AU van der Steenstraten, F de Ru, JA Witkamp, TD AF van der Steenstraten, Femke de Ru, J. Alexander Witkamp, Theo D. TI Is microvascular compression of the vestibulocochlear nerve a cause of unilateral hearing loss? SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE anterior inferior cerebellar artery; imaging; internal auditory canal; microvascular compression syndrome; vestibulocochlear nerve ID DISABLING POSITIONAL VERTIGO; VASCULAR-DECOMPRESSION SURGERY; INFERIOR CEREBELLAR ARTERY; 8TH NERVE; SELECTION CRITERIA; SEVERE TINNITUS; CRANIAL NERVE; SYMPTOMS; TUMORS; LOOPS AB Objectives: We sought to confirm earlier findings it! the literature that microvascular compression of the vestibulocochlear nerve might cause unilateral sensorineural hearing loss. We measured the length and width of the internal auditory canal (IAC) to investigate a possible association between a narrow porus, the presence of an anterior inferior cerebellar artery (AICA) loop, and the development of a microvascular compression syndrome. Methods: We performed a prospective blinded analysis of 167 magnetic resonance imaging scans of the cerebellopontine angle. The presence of an AICA loop was scored. We analyzed these 167 patients for unilateral sensorineural hearing loss, which was defined as an interaural difference of 20 dB at 1 frequency or 10 dB at 2 or more frequencies. Furthermore, the width and length of the IAC on magnetic resonance imaging were measured. Results: An AICA loop was identified in 94% of the 167 patients. There were 196 type I loops, 106 type II loops, and 14 type III loops. Sixty-six patients had unexplained unilateral hearing loss. There was no association between type II and III vascular loops, the width of the IAC, and unilateral hearing loss (p > .05). Conclusions: In this study we found no association between the depth of extension of the AICA loop into the IAC and the presence of unilateral hearing loss. C1 UMC Utrecht, Dept Otorhinolaryngol, NL-3584 CX Utrecht, Netherlands. UMC Utrecht, Dept Radiol, NL-3584 CX Utrecht, Netherlands. RP de Ru, JA (reprint author), UMC Utrecht, Dept Otorhinolaryngol, Heidelberglaan 100, NL-3584 CX Utrecht, Netherlands. CR APPLEBAUM EL, 1985, AM J OTOL, P110 Brookes GB, 1996, AM J OTOL, V17, P569 Camp JD, 1939, AM J ROENTGENOL RADI, V41, P713 Dandy WE, 1934, AM J SURG, V24, P447, DOI 10.1016/S0002-9610(34)90403-7 Ebenius B, 1934, ACTA RADIOL, V15, P284, DOI 10.3109/00016923409135056 EHNI G, 1945, ARCH NEURO PSYCHIATR, V53, P205 GRAF K, 1952, GESCHWULTSE OHRES HE, P238 HOUSE WF, 1977, NEUROLOGICAL SURG EA, P150 JANNETTA PJ, 1984, NEW ENGL J MED, V310, P1700, DOI 10.1056/NEJM198406283102604 JANNETTA PJ, 1975, SURG FORUM, V26, P467 Kuncz A, 2006, CEPHALALGIA, V26, P266, DOI 10.1111/j.1468-2982.2005.01030.x Lang J, 1984, Adv Otorhinolaryngol, V34, P8 Makins AE, 1998, LARYNGOSCOPE, V108, P1739, DOI 10.1097/00005537-199811000-00027 MARTIN RG, 1980, NEUROSURGERY, V6, P483 MCCABE BF, 1989, AM J OTOL, V10, P117 McDermott AL, 2003, CLIN OTOLARYNGOL, V28, P75, DOI 10.1046/j.1365-2273.2003.00662.x MOLLER AR, 1991, ACTA NEUROCHIR, V113, P18, DOI 10.1007/BF01402109 Moller AR, 1993, NEUROSURGICAL TOPICS, P105 MOLLER MB, 1990, ANN OTO RHINOL LARYN, V99, P724 MOLLER MB, 1993, ACTA NEUROCHIR, V125, P75, DOI 10.1007/BF01401831 MOLLER MB, 1993, LARYNGOSCOPE, V103, P421 Ouaknine G E, 1982, Adv Otorhinolaryngol, V28, P121 PHELPS PD, 1975, BRIT J RADIOL, V48, P973 Ryu H, 1988, Adv Otorhinolaryngol, V42, P280 SASAKI T, 1987, SURG NEUROL, V27, P141 SUNDERLAND S, 1945, BRAIN, V68, P23, DOI 10.1093/brain/68.1.23 Weisenburg TH, 1910, JAMA-J AM MED ASSOC, V54, P1600 NR 27 TC 6 Z9 6 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD APR PY 2007 VL 116 IS 4 BP 248 EP 252 PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA 159CV UT WOS:000245843900003 PM 17491521 ER PT J AU Piccirillo, JF Finnell, J Vlahiotis, A Chole, RA Spitznagel, E AF Piccirillo, Jay F. Finnell, Joshua Vlahiotis, Anna Chole, Richard A. Spitznagel, Edward, Jr. TI Relief of idiopathic subjective tinnitus - Is gabapentin effective? SO ARCHIVES OF OTOLARYNGOLOGY-HEAD & NECK SURGERY LA English DT Article ID RANDOMIZED CONTROLLED-TRIAL; INVENTORY; PAIN; MECHANISMS AB Objective: To assess the therapeutic benefit of gabapentin (Neurontin) for subjective idiopathic troublesome tinnitus. Design: An 8-week, double-blind, randomized clinical trial. Setting: Academic otolaryngology clinic in St Louis, Mo. Subjects: One hundred thirty-five subjects with severe idiopathic subjective tinnitus of 6 months' duration or longer. Intervention: Gabapentin, at a maintenance dosage of 900 to 3600 mg/d for 8 weeks, or lactose placebo. Main Outcome Measure: Change in the Tinnitus Handicap inventory score from baseline to the study end point. Results: The overall change in the Tinnitus Handicap inventory score for the entire cohort from baseline to week 8 was 11.2; the change among the 59 subjects randomized to the gabapentin arm was 11.3 and the change among the 56 subjects in the placebo arm was 11.0. The difference was 0.03 (95% confidence interval, -5.5 to 6.2; P=.91). Conclusion: Gabapentin is no more effective than placebo for the relief of idiopathic subjective tinnitus. C1 Washington Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, Div Clin Outcomes Res, St Louis, MO 63110 USA. Washington Univ, Sch Med, Div Biostat, St Louis, MO 63110 USA. RP Piccirillo, JF (reprint author), Washington Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, Div Clin Outcomes Res, Campus Box 8115,660 S Euclid Ave, St Louis, MO 63110 USA. EM piccirilloj@ent.wustl.edu RI Finnell, Joshua/C-7826-2011 CR Andersson G, 1999, BRIT J AUDIOL, V33, P201 Attal N, 1998, EUR NEUROL, V40, P191, DOI 10.1159/000007979 Backonja M, 1998, JAMA-J AM MED ASSOC, V280, P1831, DOI 10.1001/jama.280.21.1831 BARTNIK G., 2001, SCAND AUDIOL S, V52, P206 BASKILL JL, 2000, P 6 INT TINN SEM LON, P424 Bauer CA, 2001, JARO, V2, P54 Bauer CA, 2006, LARYNGOSCOPE, V116, P675, DOI 10.1097/01.MLG.0000216812.65206.CD Bayar N, 2001, J OTOLARYNGOL, V30, P300, DOI 10.2310/7070.2001.19597 BECK AT, 1961, ARCH GEN PSYCHIAT, V4, P561 Davis A, 2000, TINNITUS HDB, P1 DEROGATIS LR, 1983, PSYCHOL MED, V13, P595 DOBIE RA, 1993, AM J OTOL, V14, P18 Dobie RA, 1999, LARYNGOSCOPE, V109, P1202, DOI 10.1097/00005537-199908000-00004 Folmer RL, 2001, OTOLARYNG HEAD NECK, V124, P394, DOI 10.1067/mhn.2001.114673 JASTREBOFF PJ, 1993, BRIT J AUDIOL, V27, P7, DOI 10.3109/03005369309077884 JASTREBOFF PJ, 1990, NEUROSCI RES, V8, P221, DOI 10.1016/0168-0102(90)90031-9 Jastreboff P J, 2000, J Am Acad Audiol, V11, P162 Kaltenbach J A, 2000, J Am Acad Audiol, V11, P125 KUK FK, 1990, EAR HEARING, V11, P434, DOI 10.1097/00003446-199012000-00005 LENARZ T, 1993, EUR ARCH OTO-RHINO-L, V249, P441 Lockwood AH, 2002, NEW ENGL J MED, V347, P904, DOI 10.1056/NEJMra013395 Lockwood A H, 1999, Scand Audiol Suppl, V51, P47 MEIKLE MB, 1984, OTOLARYNG HEAD NECK, V92, P689 Moller A R, 2000, J Am Acad Audiol, V11, P115 Newman CW, 1996, ARCH OTOLARYNGOL, V122, P143 Newman C W, 1998, J Am Acad Audiol, V9, P153 Rowbotham M, 1998, JAMA-J AM MED ASSOC, V280, P1837, DOI 10.1001/jama.280.21.1837 Seidman MD, 1996, OTOLARYNG CLIN N AM, V29, P455 Simpson JJ, 1999, TRENDS PHARMACOL SCI, V20, P12, DOI 10.1016/S0165-6147(98)01281-4 TONNDORF J, 1987, HEARING RES, V28, P271, DOI 10.1016/0378-5955(87)90054-2 Xiao W.-H., 1995, Society for Neuroscience Abstracts, V21, P897 Zapp J J, 2001, Ear Nose Throat J, V80, P114 NR 32 TC 27 Z9 30 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610-0946 USA SN 0886-4470 J9 ARCH OTOLARYNGOL JI Arch. Otolaryngol. Head Neck Surg. PD APR PY 2007 VL 133 IS 4 BP 390 EP 397 DI 10.1001/archotol.133.4.390 PG 8 WC Otorhinolaryngology; Surgery SC Otorhinolaryngology; Surgery GA 156DP UT WOS:000245628600013 PM 17438255 ER PT J AU Davis, PB Paki, B Hanley, PJ AF Davis, Paul B. Paki, Bardia Hanley, Peter J. TI Neuromonics Tinnitus Treatment: Third clinical trial SO EAR AND HEARING LA English DT Article; Proceedings Paper CT 17th Annual Convention of the American-Academy-of-Audiology CY 2005 CL Washington, DC SP Amer Acad Audiol ID MUSCLE-RELAXATION; HEARING-LOSS; MANAGEMENT; THERAPY; MUSIC AB Objectives: The Neuromonics Tinnitus Treatment combines the use of a novel approach to acoustic stimulation with a structured program of counseling and support by a clinician specifically trained in tinnitus rehabilitation. The distinctive acoustic component has been designed to provide stimulation to auditory pathways deprived by hearing loss, engage positively with the limbic system, and allow intermittent, momentary tinnitus perception within a pleasant and relaxing stimulus, thereby facilitating desensitization to the tinnitus signal. The purposes of this study were (1) to demonstrate the efficacy of the treatment, when enhanced with various modifications since previously reported trials and (2) to test the relative clinical effectiveness of two variations of the approach. In the first, intermittent tinnitus perception was facilitated throughout treatment through the use of a stimulus in which intensity peaks allowed the patients' tinnitus perception to be completely covered up, whereas in the intensity troughs their tinnitus was briefly discernible. In the second, subjects experienced little tinnitus perception while listening to the treatment for the first 2 mo, then experienced intermittent perception. Design: Thirty-five subjects with a predominantly moderate to severe level of tinnitus-related distress before treatment were randomly allocated into one of two treatment groups, corresponding to the two stage-based variations of the Neuromonics Tinnitus Treatment. Participants were provided with a high-fidelity personal sound player with earphones and an acoustic stimulus that had been spectrally modified according to their individual audiometric profile. They were instructed to use the acoustic stimulus for at least 2 hr per day, particularly at those times when their tinnitus was usually disturbing. Each group had equal amounts of clinician time for education, monitoring, and support. Results: At 2, 4, 6, and 12 mo after commencing treatment, both groups displayed clinically and statistically significant improvements in tinnitus distress, awareness, and minimum masking levels as well as loudness discomfort levels. Improvements increased with time over the first 6 mo of therapy, at which time 91% of all subjects across the two groups reported an improvement in tinnitus disturbance (as measured by the Tinnitus Reaction Questionnaire) of at least 40%, with a mean improvement of 65%. Also, 80% of subjects at 6 mo reported a level of tinnitus disturbance that was no longer clinically significant. There was some indication of a more consistent benefit over 12 mo for the group that was provided initially with a high level of tinnitus interaction; however, inter-group differences were not statistically significant. A relation between reported treatment usage (hours per day) and clinical outcomes was observed, suggesting that a "dosage effect" may apply with the stimulus provided. Conclusions: This study found that the Neuromonics Tinnitus Treatment provides rapid and profound improvements to the severity of tinnitus symptoms and their effect on the subject's quality of life. This was a consistent effect, provided by a treatment that subjects reported as being pleasant to use. Both of the stage-based variations of the treatment that were tested in this study were shown to be successful in achieving these outcomes. C1 Curtin Univ Technol, Div Hlth Sci, Perth, WA 6845, Australia. Neuromonics Pty Ltd, Sydney, NSW, Australia. RP Davis, PB (reprint author), Curtin Univ Technol, Div Hlth Sci, GPO Box U1987, Perth, WA 6845, Australia. 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PD APR PY 2007 VL 28 IS 2 BP 242 EP 259 DI 10.1097/AUD.0b013e3180312619 PG 18 WC Audiology & Speech-Language Pathology; Otorhinolaryngology SC Audiology & Speech-Language Pathology; Otorhinolaryngology GA 148OR UT WOS:000245085000010 PM 17496674 ER PT J AU Canlon, B Henderson, D Salvi, R AF Canlon, Barbara Henderson, Donald Salvi, Richard TI Pharmacological strategies for prevention and treatment of hearing loss and tinnitus SO HEARING RESEARCH LA English DT Editorial Material C1 Karolinska Inst, S-10401 Stockholm, Sweden. SUNY Buffalo, Buffalo, NY 14260 USA. RP Canlon, B (reprint author), Karolinska Inst, S-10401 Stockholm, Sweden. NR 0 TC 4 Z9 5 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-5955 J9 HEARING RES JI Hear. Res. PD APR PY 2007 VL 226 IS 1-2 BP 1 EP 2 DI 10.1016/j.heares.2007.02.006 PG 2 WC Audiology & Speech-Language Pathology; Neurosciences; Otorhinolaryngology SC Audiology & Speech-Language Pathology; Neurosciences & Neurology; Otorhinolaryngology GA 162UW UT WOS:000246116000001 ER PT J AU Robinson, SK Viirre, ES Stein, MB AF Robinson, Shannon K. Viirre, Erik S. Stein, Murray B. TI Antidepressant therapy in tinnitus SO HEARING RESEARCH LA English DT Article; Proceedings Paper CT Conference on Pharmcological Strategies for Prevention and Treatment of Hearing Loss and Tinnitus CY OCT 12, 2005 CL Niagara Falls, CANADA SP Amer Bio Hlth, Auris Med, CepTor, State Univ New York Buffalo, Col Arts & Sci, John R Oishei Fdn, Kinex Pharmaceut, Natl Inst Occupat Safety & Hlth, Off Naval Res, Sound Pharmaceut, Spectra Serv, Tucker Davis Technol, US Army Med Res & Mat Command DE tinnitus; antidepressants ID PSYCHIATRIC DIAGNOSES; SUBJECTIVE TINNITUS; AMITRIPTYLINE; IMIPRAMINE; TRIAL; DISORDERS; NORTRIPTYLINE; ASSOCIATION; COMORBIDITY; VENLAFAXINE AB Objective: Review the literature on the co-morbidity of depression and anxiety with tinnitus. Briefly consider proposed mechanisms by which antidepressants might be helpful for tinnitus, including treatment of co-morbid depression and anxiety and a more direct serotonergic mechanism of tinnitus. Survey the literature on antidepressants and tinnitus including tinnitus reported as a side effect of antidepressants (phenelzine, amitriptyline, protriptyline, doxepin, imipramine, fluoxetine, trazadone, bupropion, venlafaxine), tinnitus associated with withdrawal of antidepressants (venlafaxine and sertraline) and antidepressants as a treatment for tinnitus (case reports-fluoxetine and paroxetine, retrospective reviews - imipramine and selective serotonin reuptake inhibitors, single blind trials of amitriptyline and double blind placebo controlled trials of trimipramine, nortriptyline, paroxetine and sertraline). Provide suggestions on future directions, specifically replication of prior studies and a dose finding study of paroxetine for the treatment of tinnitus. (C) 2006 Elsevier B.V. All rights reserved. C1 Univ Calif San Diego, Sch Med, Vet Adm San Diego Healthcare Syst, Dept Psychiat, La Jolla, CA 92161 USA. Univ Calif San Diego, Dept Surg, Div Otolaryngol Head & Neck Surg, San Diego, CA 92039 USA. Univ Calif San Diego, Vet Adm San Diego Healthcare Syst, Sch Med, Dept Psychiat, San Diego, CA 92039 USA. Univ Calif San Diego, Vet Adm San Diego Healthcare Syst, Sch Med, Dept Family & Prevent Med, San Diego, CA 92039 USA. RP Robinson, SK (reprint author), Univ Calif San Diego, Sch Med, Vet Adm San Diego Healthcare Syst, Dept Psychiat, La Jolla, CA 92161 USA. EM skrobinson@ucsd.edu; eviirre@ucsd.edu; mstein@ucsd.edu CR AHMAD S, 1995, AM FAM PHYSICIAN, V51, P1830 Andersson Gerhard, 2000, Scandinavian Journal of Behaviour Therapy, V29, P57 ATTIAS J, 1993, AUDIOLOGY, V32, P205 Bayar N, 2001, J OTOLARYNGOL, V30, P300, DOI 10.2310/7070.2001.19597 Begg C, 1996, JAMA-J AM MED ASSOC, V276, P637, DOI 10.1001/jama.276.8.637 Christensen RC, 2001, OTOLARYNG HEAD NECK, V125, P436, DOI 10.1067/mhn.2001.118688 DOBIE RA, 1993, AM J OTOL, V14, P18 EVANS DL, 1981, J CLIN PSYCHOPHARM, V1, P404 Farah A, 1996, AM J PSYCHIAT, V153, P576 FEDER R, 1990, J CLIN PSYCHIAT, V51, P85 FEIGHNER JP, 1985, J CLIN PSYCHIAT, V46, P369 First MB, 1998, STRUCTURED CLIN INTE Folmer R. 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Res. PD APR PY 2007 VL 226 IS 1-2 BP 221 EP 231 DI 10.1016/j.heares.2006.08.004 PG 11 WC Audiology & Speech-Language Pathology; Neurosciences; Otorhinolaryngology SC Audiology & Speech-Language Pathology; Neurosciences & Neurology; Otorhinolaryngology GA 162UW UT WOS:000246116000022 PM 16973315 ER PT J AU Kaltenbach, JA Zhang, JS AF Kaltenbach, James A. Zhang, Jinsheng TI Intense sound-induced plasticity in the dorsal cochlear nucleus of rats: Evidence for cholinergic receptor upregulation SO HEARING RESEARCH LA English DT Article; Proceedings Paper CT Conference on Pharmcological Strategies for Prevention and Treatment of Hearing Loss and Tinnitus CY OCT 12, 2005 CL Niagara Falls, CANADA SP Amer Bio Hlth, Auris Med, CepTor, State Univ New York Buffalo, Col Arts & Sci, John R Oishei Fdn, Kinex Pharmaceut, Natl Inst Occupat Safety & Hlth, Off Naval Res, Sound Pharmaceut, Spectra Serv, Tucker Davis Technol, US Army Med Res & Mat Command DE dorsal cochlear nucleus; noise exposure; carbachol; atropine; plasticity; tinnitus ID SPONTANEOUS NEURAL ACTIVITY; PRIMARY AUDITORY-CORTEX; INDUCED HEARING-LOSS; HAIR CELL LOSS; INFERIOR COLLICULUS; ACOUSTIC TRAUMA; BRAIN-STEM; GUINEA-PIG; INDUCED HYPERACTIVITY; SYNAPTIC ENDINGS AB Previous studies in a number of species have demonstrated that spontaneous activity in the dorsal cochlear nucleus (DCN) becomes elevated following exposure to intense sound. This condition of hyperactivity has aroused considerable interest because it may represent an important neural correlate of tinnitus. There is some evidence that neurons in the superficial DCN, such as cartwheel, stellate and fusiform cells, may contribute to the level of hyperactivity induced by intense sound, although the relative importance of these different cell types is unknown. In the present study, we sought to determine the effect of intense sound exposure on multiunit spontaneous activity both at the DCN surface and in the fusiform. cell layer and to examine the influence of cholinergic input to DCN circuits on the level of activity in the fusiform cell layer. Rats were studied in two groups, one of which had been exposed to a continuous intense sound (10 kHz 127 dB SPL) for 4 h while the other group served as unexposed controls. Between 30 and 52 days post-exposure, recordings of multiunit activity were performed at the DCN surface as well as in the middle of the fusiform cell layer. Changes in fusiform cell layer activity were also studied in response to superficial applications of the cholinergic agonist, carbachol, either alone or following pre-application of the cholinergic antagonist, atropine. The results demonstrated that multiunit spontaneous activity in the rat DCN was generally much higher in both control and exposed animals relative to that which has been observed in other species. This activity was significantly higher at the DCN surface of sound-exposed animals than that of controls. In contrast, hyperactivity could not be demonstrated in the fusiform cell layer of sound-exposed animals. Carbachol administration most commonly caused suppression of fusiform cell layer activity. However, this suppression was considerably stronger in the DCN of sound-exposed animals than in controls. These findings suggest that, hyperactivity at the DCN surface of exposed rats may arise as a consequence of more highly activated neurons in the molecular layer, such as cartwheel and/or stellate cells, and that the lack of hyperactivity in the fusiform cell layer may be the result of inhibition of fusiform cells by these inhibitory interneurons. Although this finding does not rule out fusiform cells as possible sources of hyperactivity in other species, or even in the rat after short post-exposure recovery periods, the enhanced sensitivity of the fusiform cell layer to cholinergic stimulation suggests that in the rat, at least after prolonged post-exposure recovery periods, increased inhibition of activity in this layer by more superficially located neurons may result from an upregulation of receptors for cholinergic input. This upregulation may be greater in rats than in other species due to the relatively heavy cholinergic input that exists in the cochlear nucleus of this species. (C) 2006 Elsevier B.V. All rights reserved. C1 Wayne State Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, Detroit, MI 48201 USA. RP Kaltenbach, JA (reprint author), Wayne State Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, Detroit, MI 48201 USA. 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Res. PD APR PY 2007 VL 226 IS 1-2 BP 232 EP 243 DI 10.1016/j.heares.2006.07.001 PG 12 WC Audiology & Speech-Language Pathology; Neurosciences; Otorhinolaryngology SC Audiology & Speech-Language Pathology; Neurosciences & Neurology; Otorhinolaryngology GA 162UW UT WOS:000246116000023 PM 16914276 ER PT J AU Yang, G Lobarinas, E Zhang, LY Turner, J Stolzberg, D Salvi, R Sun, W AF Yang, Guang Lobarinas, Edward Zhang, Liyan Turner, Jeremy Stolzberg, Daniel Salvi, Richard Sun, Wei TI Salicylate induced tinnitus: Behavioral measures and neural activity in auditory cortex of awake rats SO HEARING RESEARCH LA English DT Article; Proceedings Paper CT Conference on Pharmcological Strategies for Prevention and Treatment of Hearing Loss and Tinnitus CY OCT 12, 2005 CL Niagara Falls, CANADA SP Amer Bio Hlth, Auris Med, CepTor, State Univ New York Buffalo, Col Arts & Sci, John R Oishei Fdn, Kinex Pharmaceut, Natl Inst Occupat Safety & Hlth, Off Naval Res, Sound Pharmaceut, Spectra Serv, Tucker Davis Technol, US Army Med Res & Mat Command DE salicylate; tinnitus; auditory cortex; spontaneous activity; behavior; startle reflex; field potential ID DORSAL COCHLEAR NUCLEUS; INFERIOR COLLICULUS; ANIMAL-MODEL; OTOTOXICITY; NEURONS; CISPLATIN; RESPONSES; SOUND; ISOFLURANE; FREQUENCY AB Neurophysiological studies of salicylate-induced tinnitus have generally been carried out under anesthesia, a condition that abolishes the perception of tinnitus and depresses neural activity. To overcome these limitations, measurement of salicylate induced tinnitus were obtained from rats using schedule induced polydipsia avoidance conditioning (SIPAC) and gap pre-pulse inhibition of acoustic startle (GPIAS). Both behavioral measures indicated that tinnitus was present after treatment with 150 and 250 mg/kg of salicylate; measurements with GPIAS indicated that the pitch of the tinnitus was near 16 kHz. Chronically implanted microwire electrode arrays were used to monitor the local field potentials and spontaneous discharge rate from multiunit clusters in the auditory cortex of awake rats before and after treatment with 150 mg/kg of salicylate. The amplitude of the local field potential elicited with 60 dB SPL tone bursts increased significantly 2 h after salicylate treatment particularly at 16-20 kHz; frequencies associated with the tinnitus pitch. Field potential amplitudes had largely recovered 1-2 days post-salicylate when behavioral results showed that tinnitus was absent. The mean spontaneous spike recorded from the same multiunit cluster pre- and post-salicylate decreased from 22 spikes/s before treatment to 14 spikes/s 2 h post-salicylate and recovered I day post-treatment. These preliminary physiology data suggest that salicylate induced tinnitus is associated with sound evoked hyperactivity in auditory cortex and spontaneous hypoactivity. (C) 2006 Elsevier B.V. All rights reserved. C1 SUNY Buffalo, Dept Commun Disorders & Sci, Ctr Hearing & Deafness, Buffalo, NY 14214 USA. YueYang Hosp, Dept Otolaryngol, Shanghai, Peoples R China. So Illinois Univ, Sch Med, Dept Surg Otolaryngol & Pharmacol, Carbondale, IL 62901 USA. RP Sun, W (reprint author), SUNY Buffalo, Dept Commun Disorders & Sci, Ctr Hearing & Deafness, Buffalo, NY 14214 USA. 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Res. PD APR PY 2007 VL 226 IS 1-2 BP 244 EP 253 DI 10.1016/j.heares.2006.06.013 PG 10 WC Audiology & Speech-Language Pathology; Neurosciences; Otorhinolaryngology SC Audiology & Speech-Language Pathology; Neurosciences & Neurology; Otorhinolaryngology GA 162UW UT WOS:000246116000024 PM 16904853 ER PT J AU Schmidt, CM Bartholomaus, E Deuster, D Heinecke, A Dinnesen, AG AF Schmidt, C. -M. Bartholomaeus, E. Deuster, D. Heinecke, A. Dinnesen, A. G. TI The "Muenster classification" of high frequency hearing loss following cisplatin chemotherapy SO HNO LA German DT Article DE cisplatin; children; audiometry; classification; high frequency hearing loss ID SARCOMA PATIENTS; BRAIN-TUMORS; GUINEA-PIG; OTOTOXICITY; CHILDREN; THERAPY; SYSTEM AB Background. Slight high frequency hearing loss following cisplatin chemotherapy can be proof of an ototoxic effect even when hearing ability is not yet clinically affected. To answer scientific questions, such as the relationship between cisplatin ototoxicity and drug regime or individual tolerance, early detection of ototoxicity and a classification relating to intensity and the affected frequencies are required. A search for relevant literature resulted the WHO-classification (1991) describing clinically relevant hearing loss and two high frequency hearing loss classifications published by Khan et al. (1982) and Brock et al. (1991). Their application is compared to a new, proprietary classification. Patients and methods. 55 patients (32 boys, 23 girls) undergoing cisplatin chemotherapy at Muenster University Hospital from 1999 to 2004 underwent audiometric tests in our department. From this data we developed a grading system, that was based on the WHO classification, but paid special attention to early ototoxic effects, to intensity of hearing loss and to the frequencies affected: Grade 0 (normal hearing) includes hearing loss of not more than 10 dB in all frequencies. Grade 1 (beginning hearing loss) encompasses > 10 dB up to 20 dB in at least one frequency or tinnitus. Grade 2 (moderate impairment) describes hearing loss >= 4 kHz and differentiates 2a (> 20 to 40 dB), 2b (> 40 to 60 dB) and 2c (> 60 dB). Hearing loss < 4 kHz > 20 dB in grade 3 (severe impairment, hearing aids needed) is further classified according to grade 2 in a, b and c. Grade 4 (loss of function) finally decribes average hearing loss < 4 kHz of at least 80 dB. This classification is compared to the two high frequency hearing loss classifications (Khan et al. and Brock et al.). Results. The Muenster classification, compared to Khan et al. and Brock et al., demonstrated the best results in the early detection of hearing loss: All children with hearing loss of at least 20 dB after therapy had already shown pathological audiograms during treatment, when those audiograms were assessed by our classification. All children whose audiograms were flagged as pathological by our classification finally developed hearing loss. In terms of the prediction of hearing loss, our classification evualated processing audiograms with a sensitivity, specifity and efficiency of 1.0. Progressive hearing loss was detected in 45 patients (Khan et al. 30, Brock et al. 38). Therefore our classification showed a better suitability for monitoring hearing loss than the other classifications. Conclusion. The Muenster classification is a suitable new basis for scientific questions concerning cisplatin ototoxicity. It detects hearing loss earlier and maps progression of hearing loss more precisely than the existing high frequency classifications (Khan et al. and Brock et al.). C1 Univ Klinikum Munster, Klin & Poliklin Phoniatrie & Padaudiol, D-48149 Munster, Germany. KKS, Munster, Germany. RP Schmidt, CM (reprint author), Univ Klinikum Munster, Klin & Poliklin Phoniatrie & Padaudiol, Kardinal von Galen Ring 10, D-48149 Munster, Germany. EM michael.schmidt@uni-muenster.de RI Deuster, Dirk/A-2479-2012; Deuster, Dirk/L-4635-2014 OI Deuster, Dirk/0000-0002-3476-3300 CR Black FO, 2001, OTOL NEUROTOL, V22, P662, DOI 10.1097/00129492-200109000-00018 Bokemeyer C, 1998, BRIT J CANCER, V77, P1355, DOI 10.1038/bjc.1998.226 BROCK PR, 1991, MED PEDIATR ONCOL, V19, P295, DOI 10.1002/mpo.2950190415 Huang E, 2002, INT J RADIAT ONCOL, V52, P599, DOI 10.1016/S0360-3016(01)02641-4 Ilveskoski I, 1996, MED PEDIATR ONCOL, V27, P26 Janssen T, 2005, HNO, V53, P121, DOI 10.1007/s00106-004-1179-9 Kaltenbach JA, 2002, J NEUROPHYSIOL, V88, P699, DOI 10.1152/jn00893.2001 KHAN AB, 1982, CANCER TREAT REP, V66, P2013 KOMUNE S, 1981, OTOLARYNG HEAD NECK, V89, P275 Langer T, 2004, PEDIATR BLOOD CANCER, V42, P373, DOI 10.1002/pbc.10325 Prim M P, 2001, Acta Otorrinolaringol Esp, V52, P367 Reuter W, 1997, HNO, V45, P147, DOI 10.1007/s001060050104 RUIZ L, 1989, CANCER RES, V49, P742 SCHELL MJ, 1989, J CLIN ONCOL, V7, P754 Sergi B, 2003, HEARING RES, V182, P56, DOI 10.1016/S0378-5955(03)00142-4 Simon T, 2002, KLIN PADIATR, V214, P149, DOI 10.1055/s-2002-33179 Stelmachowicz PG, 2004, ARCH OTOLARYNGOL, V130, P556, DOI 10.1001/archotol.130.5.556 TANGE RA, 1984, ARCH OTO-RHINO-LARYN, V239, P41, DOI 10.1007/BF00454261 Tsukasaki N, 2000, HEARING RES, V149, P189, DOI 10.1016/S0378-5955(00)00182-9 World Health Organization, 1991, REP INF WORK GROUP P NR 20 TC 10 Z9 10 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013 USA SN 0017-6192 J9 HNO JI HNO PD APR PY 2007 VL 55 IS 4 BP 299 EP + DI 10.1007/s00106-005-1368-1 PG 7 WC Otorhinolaryngology SC Otorhinolaryngology GA 154FW UT WOS:000245493300012 PM 16437215 ER PT J AU Mcferran, DJ Baguley, DM AF Mcferran, D. J. Baguley, D. M. TI Acoustic shock SO JOURNAL OF LARYNGOLOGY AND OTOLOGY LA English DT Review DE occupational noise; Hyperacusis; tinnitus; serotonin; ear diseases ID TENSOR TYMPANI; HYPERACUSIS; OPERATORS; NOISE AB Acoustic shock is a recently recognised clinical entity: following an abrupt, intense and unanticipated acoustic stimulus, usually delivered by a telephone handset or headset, some individuals report a symptom cluster that includes otalgia, altered hearing, aural fullness, imbalance, tinnitus, dislike or even fear of loud noises, and anxiety and/or depression. Symptoms start shortly after the triggering acoustic incident and can be short-lived or can last for a considerable time. If persistent, the condition can lead to significant disability. Proposed mechanisms include involvement of the tensor tympani muscle, hyperexcitability of central auditory pathways, and a precursive state of raised anxiety or arousal. A formal treatment programme has not yet been proposed, but the potential utility of modern therapeutic techniques for tinnitus and hyperacusis are considered. Given the large number of UK residents working in telephone call centres, this condition is of considerable clinical importance. C1 Essex Cty Hosp, Dept Otolaryngol Head & Neck Surg, Colchester CO3 3NB, Essex, England. Addenbrookes Hosp, Dept Audiol, Cambridge, England. RP Mcferran, DJ (reprint author), Essex Cty Hosp, Dept Otolaryngol Head & Neck Surg, Lexden Rd, Colchester CO3 3NB, Essex, England. CR ALEXANDER RW, 1979, J OCCUP ENVIRON MED, V21, P21 American Psychiatric Association, 2000, DIAGN STAT MAN MENT, P467 ANDERSSON G, 2002, P 7 INT TINN SEM FRE, P197 BLUMENTHAL TD, 1991, PSYCHOPHYSIOLOGY, V28, P296, DOI 10.1111/j.1469-8986.1991.tb02198.x Hallam RS, 1984, CONTRIBUTIONS MED PS, V3, P31 Hinke K, 1999, INVESTIGATION TELEPH *HLTH SAF EX, 1989, NOIS WORK REG 1989 S *INT TEL UN, 1998, TEL STAND SECT INT T Jastreboff P, 2000, TINNITUS HDB, P357 JASTREBOFF PJ, 1993, BRIT J AUDIOL, V27, P7, DOI 10.3109/03005369309077884 Katzenell U, 2001, OTOL NEUROTOL, V22, P321, DOI 10.1097/00129492-200105000-00009 Kierner AC, 2002, HEARING RES, V165, P48, DOI 10.1016/S0378-5955(01)00419-1 KLOCKHOFF I, 1981, P 4 INT S AC IMP MEA, P69 Lawton BW, 2003, P I ACOUSTICS, V25, P249 LETHEM J, 1983, BEHAV RES THER, V21, P401, DOI 10.1016/0005-7967(83)90009-8 MARRIAGE J, 1995, J LARYNGOL OTOL, V109, P915 MILHINCH JC, ACOUSTIC SHOCK INJUR *NATL DEF ACOUST S, 2006, SAL AC SAF PROGR NAT, P20 Patel JA, 2002, ANN OCCUP HYG, V46, P653, DOI 10.1093/annhyg/mef091 *ROY NATL I DEAF T, 1999, INDEGENT EXP Sahley TL, 1997, EFFERENT AUDITORY SY Thompson AM, 1998, BRAIN RES, V787, P175, DOI 10.1016/S0006-8993(97)01020-2 TRIFILETTI B, 2001, FACT SHEET ACOUSTIC Vernon J. A., 1996, P 5 INT TINN SEM 199, P51 Westcott M, 2006, ACTA OTO-LARYNGOL, V556, P54 NR 25 TC 3 Z9 5 PU CAMBRIDGE UNIV PRESS PI CAMBRIDGE PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND SN 0022-2151 J9 J LARYNGOL OTOL JI J. Laryngol. Otol. PD APR PY 2007 VL 121 IS 4 BP 301 EP 305 DI 10.1017/S022215107006111 PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA 224YQ UT WOS:000250484700001 PM 17306048 ER PT J AU Brewis, S Baguley, DM AF Brewis, S. Baguley, D. M. TI Management of tinnitus induced by brainstern and cerebellar infarction associated with complications of cerebello-pontine angle surgery SO JOURNAL OF LARYNGOLOGY AND OTOLOGY LA English DT Article DE tinnitus; hearing aid; infarction; brainstem ID HEARING-LOSS; REORGANIZATION AB Following surgery in the USA in 1992 to remove a large right cerebello-pontine angle turnout, a 39-year-old woman developed severe brainstem and cerebellar infarction. This left her with severe visual impairment and ataxia. She became able to communicate by means of an adapted finger-spelling alphabet. She had total hearing loss in the right ear and a mild to moderately severe sensorineural hearing loss in the left ear, and severe finnitus heard throughout the head. Additionally, she experienced hypersensitivity to sound above normal conversational levels, which evoked a synaesthetic feeling of coldness across her upper torso. Previous linear analogue hearing aid fitting had not been beneficial for either hearing or tinnitus. Careful fitting of a digital hearing aid, together with tinnitus counselling, inhibited the patient's tinnitus to 25 per cent of its former intensity after a six month acclimatisation period, and improved communication. C1 Addenbrookes Hosp, Dept Audiol 94, Cambridge CB2 2QQ, England. RP Baguley, DM (reprint author), Addenbrookes Hosp, Dept Audiol 94, Hills Rd, Cambridge CB2 2QQ, England. EM dmb29@cam.ac.uk CR Bilecen D, 2000, NEUROLOGY, V54, P765 GOODHILL V, 1950, LARYNGOSCOPE, V60, P442, DOI 10.1288/00005537-195005000-00002 Irvine DRF, 2000, HEARING RES, V147, P188, DOI 10.1016/S0378-5955(00)00131-3 Li LPH, 2003, ANN NEUROL, V53, P810, DOI 10.1002/ana.10599 Meikle M. B., 1995, MECH TINNITUS, P181 Rauschecker JP, 1999, TRENDS NEUROSCI, V22, P74, DOI 10.1016/S0166-2236(98)01303-4 Salvi R. J., 2000, TINNITUS HDB, P123 Salvi RJ, 1996, P 5 INT TINN SEM POR, P457 NR 8 TC 1 Z9 1 PU CAMBRIDGE UNIV PRESS PI CAMBRIDGE PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND SN 0022-2151 J9 J LARYNGOL OTOL JI J. Laryngol. Otol. PD APR PY 2007 VL 121 IS 4 BP 393 EP 394 DI 10.1017/SO022215107005373 PG 2 WC Otorhinolaryngology SC Otorhinolaryngology GA 224YQ UT WOS:000250484700021 PM 17403265 ER PT J AU Muluk, NB Basar, MM Oguztuerk, O Dikici, O AF Muluk, Nuray Bayar Basar, Mehmed Murad Oguztuerk, Oemer Dikici, Oguzhan TI Does subjective tinnitus cause sexual disturbance? SO JOURNAL OF OTOLARYNGOLOGY LA English DT Article DE depression; sexual dysfunction; subjective tinnitus ID MULTIPHASIC PERSONALITY-INVENTORY; ERECTILE FUNCTION IIEF; PSYCHIATRIC MORBIDITY; INTERNATIONAL INDEX; DYSFUNCTION; PREVALENCE; ASSOCIATION; POPULATION; MANAGEMENT; DISORDERS AB Objective: Tinnitus can cause psychological problems, which can affect sexual performance. The aim of this study was to investigate sexual disturbance related to the psychological problems of patients with subjective tinnitus. Materials and Method. The subjective tinnitus group with normal hearing levels consisted of 20 patients (10 male, 10 female) who were nonpsychiatric. The control group consisted of 20 healthy patients (10 male, 10 female) with normal hearing levels who did not have tinnitus and were nonpsychiatric. All subjects were married and had an active sexual life. Using a questionnaire, the subjective tinnitus loudness level score (STLL-Sc) was found. Using Zung Anxiety and Depression Scale, self-rating depression scale (SDS) was found in the study and control groups. Sexual function was assessed in all male subjects with the International Index of Erectile Functions (IIEF) and in all female subjects with the Female Sexual Function Index (FSFI). Results: In females, the satisfaction subscore was slightly lower than normal limits in both the study and control groups. In males, the IIEF showed an insignificant, negative correlation with the STLL-Sc and the SDS and a positive correlation with tinnitus duration. In females, the FSFI showed an insignificant negative correlation with the STILL-Sc and a positive correlation with tinnitus duration and the SDS. Conclusion: Sexual disturbance is seen in very quiet-and intermediate-level tinnitus sufferers in the early period of the disease. Over time, they become used to living with their tinnitus, and no loss in sexual performance is seen. In the future, we plan to investigate the sexual disturbance of patients with severe STLL-Scs. C1 Kirikkale Univ, Fac Med, Dept Otolaryngol, Kirikkale, Turkey. Kirikkale Univ, Dept Urol, Kirikkale, Turkey. Kirikkale Univ, Fac Med, Dept Psychiat, Kirikkale, Turkey. RP Muluk, NB (reprint author), Etap Sitesi,C 3 Block,No 62-43, TR-06610 Ankara, Turkey. 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A., 2000, COMPREHENSIVE TXB PS, P1577 Sanchez L, 1997, EAR HEARING, V18, P210, DOI 10.1097/00003446-199706000-00004 Simpson JJ, 1999, TRENDS PHARMACOL SCI, V20, P12, DOI 10.1016/S0165-6147(98)01281-4 SPECTOR IP, 1990, ARCH SEX BEHAV, V19, P389, DOI 10.1007/BF01541933 TYLER RS, 1983, J SPEECH HEAR DISORD, V48, P150 ZUNG WWK, 1965, ARCH GEN PSYCHIAT, V12, P63 1986, TINNITUS PATIENTS SA NR 31 TC 7 Z9 7 PU B C DECKER INC PI HAMILTON PA 50 KING STREET EAST, 2ND FLOOR, PO BOX 620, L C D 1, HAMILTON, ONTARIO L8N 3K7, CANADA SN 0381-6605 J9 J OTOLARYNGOL JI J. Otolaryngol. PD APR PY 2007 VL 36 IS 2 BP 77 EP 82 DI 10.2310/7070.2007.0002 PG 6 WC Otorhinolaryngology SC Otorhinolaryngology GA 190VL UT WOS:000248088600001 PM 17459276 ER PT J AU Westerlaken, BO de Kleine, E van der Laan, B Albers, F AF Westerlaken, Boris O. Kleine, Emile de van der Laan, Bernard Albers, Frans TI The treatment of idiopathic sudden sensorineural hearing loss using pulse therapy: A prospective, randomized, double-blind clinical trial SO LARYNGOSCOPE LA English DT Article DE idiopathic sudden sensorineural hearing loss (ISSHL); sudden hearing loss; prospective; randomized; double-blind clinical trial ID GLUCOCORTICOID THERAPY; INNER-EAR AB Objectives. The etiology and treatment of idiopathic sudden sensorineural hearing loss (ISSHL) is still unclear. The anti-inflammatory effect of corticosteroids is thought to play an important part in the recovery from ISSHL. We aimed to determine whether a more powerful anti-inflammatory technique using pulse therapy is effective in the treatment of ISSHL. Methods: In a randomized, prospective, double-blind, multicenter clinical trial, we recruited 81 patients with ISSHL. Patients were randomly allocated to pulse therapy (300 mg dexamethasone for 3 consecutive days followed by 4 days of placebo) or control treatment (prednisone 70 mg per day tapered in steps of 10 mg per day to 0 mg). The primary outcome was hearing recovery as measured by pure-tone audiometry and speech audiometry after 12 months. Secondary outcomes were subjective parameters such as hearing recovery, tinnitus, vertigo, and a pressure sensation in the ear. Results. The overall improvement in pure-tone thresholds and speech discrimination scores was not significantly better in patients who were given dexamethasone than those who were given standard prednisone. Hearing improved from 71 dB HL to 36 dB HL in the dexamethasone group and from 75 dB HL to 42 dB HL in the prednisone group. Speech discrimination scores of 100% were achieved by 64% of dexamethasone-treated patients and by 57% of the prednisone group. Conclusion: Pulse therapy is equally effective and safe as standard-dose prednisone. Pulse therapy suppresses both humoral and cellular immune responses and therefore has a wider anti-inflammatory effect. C1 Univ Groningen, Univ Med Ctr Groningen, Dept Otorhinolaryngol, NL-9700 RB Groningen, Netherlands. Univ Med Ctr Utrecht, Dept Otorhinolaryngol, Utrecht, Netherlands. RP Westerlaken, BO (reprint author), Univ Groningen, Univ Med Ctr Groningen, Dept Otorhinolaryngol, Hanzepl 1,POB 30-001, NL-9700 RB Groningen, Netherlands. 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Acute acoustic traumas caused by an exposure to gunshot noise are common in young South Korean males in military service. Considering the significant lack of awareness on this serious issue as well as the absence of proper protective gear, an in-depth analysis is desperately needed. Method: All 3,650 soldiers performed regular periodic gunfire exercise without any hearing protective measures. Seven patients with hearing impairment after periodic gunfire visited the aeromedical squadron; all were right-handed males. Six were tested with the K-2 rifle and one was tested with a K-5 revolver. History taking, physical examination, pure-tone audiometry, and impedance audiometry were conducted. In the next periodic gunfire exercise, all 3,650 soldiers performed gunfire with unilateral hearing protection. Results: The average outcome of postexposure air conduction thresholds was 6.5 dB in the right ear and 33.1 dB in the left ear. After medical treatment, hearing impairment was much improved; however, tinnitus was not diminished. In the next periodic gunfire exercise, the result of a supplement of unilateral earplug protection proved its effectiveness on acoustic trauma caused by gunfire noise. Conclusion: Asymmetry in hearing loss is related to the position of the head during gunfire. A unilateral hearing protection device was enough to protect hearing from gunfire noise. At the same time, it can effectively prevent a potential firearm accident that can be caused by trainees mishearing the instruction of a firearm instructor if both earplugs are worn. Thus, providing a unilateral earplug for protection against acoustic trauma must be taken into serious consideration. C1 Republ Korea AF, Fighter Wing Aeromed Squadron 20, Seosan, Chungcheongnam, South Korea. RP Moon, CIS (reprint author), Republ Korea AF, Fighter Wing Aeromed Squadron 20, POB 384-21, Seosan, Chungcheongnam, South Korea. 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Med. PD APR PY 2007 VL 172 IS 4 BP 421 EP 425 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA 161YO UT WOS:000246053300018 ER PT J AU Nakagawa, N Akai, F Fukawa, N Yugami, H Kinnoto, A Majima, S Taneda, M AF Nakagawa, N. Akai, F. Fukawa, N. Yugami, H. Kinnoto, A. Majima, S. Taneda, M. TI Endovascular Stent placement of cervical internal carotid artery dissection related to a seat-belt injury: A case report SO MINIMALLY INVASIVE NEUROSURGERY LA English DT Article DE seat-belt injury; carotid artery dissection; stent; carotid cavernous fistula ID TECHNICAL CASE-REPORT; ANEURYSMS; TRAUMA; PSEUDOANEURYSM; SECONDARY AB Object: The incidence of carotid artery dissection related to blunt injury is very low, but the mortality rate is high. Rapid diagnosis and proper treatments are discussed. Clinical Presentation: A 48-year-old woman presented diplopia and pulsating tinnitus of the left ear. An angiography showed a carotid cavernous fistula (CCF) and dissection of the extra-cranial internal carotid artery (ICA). To treat the dissection, a self-expanding endovascular stent was used. She has been followed for 6 years without any event and the ICA is patent. Conclusion: Prompt diagnosis without delay and intimate follow-up is the key for the treatment of a carotid injury. Those patients who exhibit cervical bruits and/or seat-belt signs should be examined aggressively. Angioplasty with stents is amenable for patients with traumatic carotid dissections requiring vascular reconstruction in the acute stage. C1 Kinki Univ, Sch Med, Dept Neurosurg, Osakasayama Shi, Osaka 5898511, Japan. RP Nakagawa, N (reprint author), Kinki Univ, Sch Med, Dept Neurosurg, 377-2 Ohnohigashi, Osakasayama Shi, Osaka 5898511, Japan. 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Invasive Neurosurg. PD APR PY 2007 VL 50 IS 2 BP 115 EP 119 DI 10.1055/s-2007-984381 PG 5 WC Clinical Neurology; Neuroimaging; Surgery SC Neurosciences & Neurology; Surgery GA 205LK UT WOS:000249114800011 PM 17674300 ER PT J AU Ibekwe, TS Ijaduola, GTA Nwaorgu, OGB AF Ibekwe, Titus S. Ijaduola, G. Taiwo A. Nwaorgu, Onyekwere G. B. TI Tympanic membrane perforation among adults in West Africa SO OTOLOGY & NEUROTOLOGY LA English DT Article DE humid climate; perforations; tympanic membrane; sizes ID EAR AB Context: The knowledge of variations of the tympanic membrane (TM) perforations with the climatic changes in the West African subregion would help clinicians in its prevention and management. Objective: To analyze the pattern of clinical presentations and associated features of TM perforation in adults in West Africa. Design: A prospective study. Setting: Tertiary referral centre, University hospital. Patients or Other Participants: Thirty-five (35) consecutive adults with TM perforations during a 1-year period had clinical evaluation of each TM using head mirror, video otoscopy, and micro-otoscopy. Main Outcome Measures: Clinical presentations and associated features of TM perforations. Results: Thirty-five patients, 20 (57%) men and 15 (43%) women, with 42 perforated TMs were examined. Twenty-eight (80%) patients had unilateral perforations. Infection was responsible for 90.5% of cases, and trauma was responsible for the rest. Locations of perforations were central (29;69.1%), anteroinferior (4; 9.5%), posteroinferior (4; 9.5%), anterosuperior Q; 7.1%), and posterosuperior (2; 4.8%). The sizes of the perforations ranged from 1.2 to 83.2%. Large sizes of 25% and more were found to occur in humid and wet seasons, and also, clinical presentations of otorrhea (65.6%), otalgia (51.5%), tinnitus (37.1%), and ear itching (34.4%) seemed to worsen. 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PD APR PY 2007 VL 28 IS 3 BP 348 EP 352 DI 10.1097/MAO.0b013e3180311605 PG 5 WC Clinical Neurology; Otorhinolaryngology SC Neurosciences & Neurology; Otorhinolaryngology GA 152ZQ UT WOS:000245401500011 PM 17414040 ER PT J AU Tan, J Ruttiger, L Panford-Walsh, R Singer, W Schulze, H Kilian, SB Hadjab, S Zimmermann, U Kopschall, I Rohbock, K Knipper, M AF Tan, J. Ruettiger, L. Panford-Walsh, R. Singer, W. Schulze, H. Kilian, S. B. Hadjab, S. Zimmermann, U. Koepschall, I. Rohbock, K. Knipper, M. TI Tinnitus behavior and hearing function correlate with the reciprocal expression patterns of BDNF and Arg3.1/arc in auditory neurons following acoustic trauma SO NEUROSCIENCE LA English DT Article DE phantom noise; BDNF; Arg3.1/arc; plasticity; cochlea; auditory cortex ID DORSAL COCHLEAR NUCLEUS; LONG-TERM POTENTIATION; ACTIVITY-DEPENDENT PLASTICITY; CULTURED HIPPOCAMPAL-NEURONS; SPONTANEOUS NEURAL ACTIVITY; RAT INFERIOR COLLICULUS; INTENSE SOUND EXPOSURE; NEUROTROPHIC FACTOR; C-FOS; MESSENGER-RNA AB The molecular changes following sensory trauma and the subsequent response of the CNS are poorly understood. We focused on finding a molecular tool for monitoring the features of excitability which occur following acoustic trauma to the auditory system. Of particular interest are genes that alter their expression pattern during activity-induced changes in synaptic efficacy and plasticity. The expression of brain-derived neurotrophic factor (BDNF), the activity-dependent cytoskeletal protein (Arg3.1/arc), and the immediate early gene c-Fos were monitored in the peripheral and central auditory system hours and days following a traumatic acoustic stimulus that induced not only hearing loss but also phantom auditory perception (tinnitus), as shown in rodent animal behavior models. A reciprocal responsiveness of activity-dependent genes became evident between the periphery and the primary auditory cortex (AI): as c-Fos and BDNF exon IV expression was increased in spiral ganglion neurons, Arg3.1/arc and (later on) BDNF exon IV expression was reduced in AI. In line with studies indicating increased spontaneous spike activity at the level of the inferior colliculus (IC), an increase in BDNF and GABA-positive neurons was seen in the IC. The data clearly indicate the usefulness of Arg3.1/arc and BDNF for monitoring trauma-induced activity changes and the associated putative plasticity responses in the auditory system. (c) 2007 IBRO. Published by Elsevier Ltd. All rights reserved. C1 Univ Tubingen, Dept Otorhinolaryngol, Hearing Res Ctr, D-72076 Tubingen, Germany. Leibniz Inst Neurobiol, D-39118 Magdeburg, Germany. RP Knipper, M (reprint author), Univ Tubingen, Dept Otorhinolaryngol, Hearing Res Ctr, Elfriede Aulhorn Str 5, D-72076 Tubingen, Germany. 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Neurosciences SC Neurosciences & Neurology GA 148AB UT WOS:000245045800030 PM 17275194 ER PT J AU Lopez-Gonzalez, MA Moliner-Peiro, F Alfaro-Garcia, J Esteban-Ortega, F AF Lopez-Gonzalez, Miguel A. Moliner-Peiro, Fernando Alfaro-Garcia, Jorge Esteban-Ortega, Francisco TI Sulpiride plus hydroxyzine decrease tinnitus perception SO AURIS NASUS LARYNX LA English DT Article DE tinnitus; dopamine; sulpiride; hydroxyzine; neurotransmitters AB Objectives: The aim of the study is to confirm the effectiveness of sulpiride and hydroxyzine in tinnitus patients. The administration of sulpiride, a D2 antagonist of dopamine receptors, together with hydroxyzine, a subcortical sedative, covers the areas of tinnitus perception. Methods: A prospective, randomized, single blinded, placebo-control study was done in general otorhinolaryngology consultations for 20022004 in Seville and Zaragoza (Spain). One hundred and fifty patients consulted for subjective tinnitus. They were included randomly in three groups of 50. A group took sulpiride (50 mg/8 h) alone, other the same dose of sulpiride plus hydroxyzine (25 mg/12 h), and the third placebo (lactose), for 1 month. One hundred and twenty-two patients completed the study. Clinical history, tonal audiometry, tympanometry, and tinnitometry were done in the beginning and end of the study. Subjective Grading of Tinnitus Perception and visual analogical scale (0-10) were done for result evaluation. Results: Based on the Subjective Grading of Tinnitus Perception, tinnitus perception diminished by 56% in patients treated with sulpiride and by 81% in patients treated with sulpiride plus hydroxyzine. Based on the visual analogical scale, tinnitus perception diminished from 7.8 to 6.3 in the patients treated with sulpiride, and from 7.8 to 5.1 in those treated with sulpiride plus hydroxyzine. Conclusions: Sulpiride plus hydroxyzine decreases tinnitus perception. Tinnitus auditolimbic dopaminergic pathway opens wide therapeutical implications. (C) 2006 Elsevier Ireland Ltd. All rights reserved. C1 Virgen Roccio Univ Hosp, Dept Otorhinolaryngol, Seville, Spain. Quiron Clin, Zaragoza, Spain. RP Lopez-Gonzalez, MA (reprint author), C Claudio Guerin 9-5A, Seville 41005, Spain. EM malopez@cica.es CR CHUNG DY, 1984, AUDIOLOGY, V23, P441 ERLANDSSON S, 1987, British Journal of Audiology, V21, P37, DOI 10.3109/03005368709077773 FARAH L, 1956, Int Rec Med Gen Pract Clin, V169, P379 Ferreri M, 1998, Acta Psychiatr Scand Suppl, V393, P102 JASTREBOFF PJ, 1993, BRIT J AUDIOL, V27, P7, DOI 10.3109/03005369309077884 KELLER AP, 1974, LARYNGOSCOPE, V84, P998, DOI 10.1288/00005537-197406000-00014 LOPEZGONZALEZ MA, 2006, IN PRESS J OTOLARYNG Lopez-Gonzalez MA, 2005, MED HYPOTHESES, V65, P349, DOI 10.1016/j.mehy.2005.02.016 LOPEZGONZALEZ MA, 2004, TINNITUS INTEGRAL TR López-González Miguel A, 2004, Int Tinnitus J, V10, P150 Mahlke C, 2004, HEARING RES, V195, P17, DOI 10.1016/j.heares.2004.03.005 *MED MED SA, 2005, VAD INT MENGER H C, 1958, N Y State J Med, V58, P1684 Mirz F, 1999, HEARING RES, V134, P133, DOI 10.1016/S0378-5955(99)00075-1 López González M A, 2003, Acta Otorrinolaringol Esp, V54, P237 Shulman A., 1995, INT TINNITUS J, V1, P13 STEINBERG N, 1960, N Y State J Med, V60, P691 Zhang JS, 2003, EXP BRAIN RES, V153, P655, DOI 10.1007/s00221-003-1612-4 NR 18 TC 16 Z9 17 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0385-8146 J9 AURIS NASUS LARYNX JI Auris Nasus Larynx PD MAR PY 2007 VL 34 IS 1 BP 23 EP 27 DI 10.1016/j.anl.2006.09.021 PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA 139CK UT WOS:000244409500006 PM 17118597 ER PT J AU Kanzaki, S Araki, Y Okamoto, Y Kurita, A Ogawa, K AF Kanzaki, Sho Araki, Yasutomo Okamoto, Yasuhide Kurita, Akihiro Ogawa, Kaoru TI Cholesterol granuloma surrounding the endolymphatic sac SO AURIS NASUS LARYNX LA English DT Article DE cholesterol granuloma; endolymphatic sac; tumor; surgery ID PETROUS APEX; TUMORS; SURGERY AB We report a unique case of cholesterol granuloma (CG) surrounding the endolymphatic sac (ES). A 49-year-old man presented with the left side of sensorineural hearing loss, tinnitus, and vertigo. Magnetic resonance and computed tomography imaging revealed a CG surrounding the left ES. The patient initially underwent left transmastoid surgical resection of the tumor. At the time of surgery, brown fluid was aspirated from the tumor, but no other tumors were found. Histopathological examination revealed that the tumor contained cholesterol crystals, confirming the diagnosis of CG. At his 12-month postoperative follow-up, there was no evidence of recurrence. We discuss the radiology, pathology, and surgical removal of CGs surrounding ES. (C) 2006 Published by Elsevier Ireland Ltd. C1 Keio Univ, Sch Med, Dept Otorhinolaryngol, Shinjuku Ku, Tokyo 1608582, Japan. Tokyo Elect Power Co Hosp, Tokyo, Japan. RP Kanzaki, S (reprint author), Keio Univ, Sch Med, Dept Otorhinolaryngol, Shinjuku Ku, 35 Shinanomachi, Tokyo 1608582, Japan. EM skan@sc.itc.keio.ac.jp RI Kanzaki, Sho/B-3100-2014 OI Kanzaki, Sho/0000-0001-9056-0850 CR Beaumont G D, 1966, J Laryngol Otol, V80, P236, DOI 10.1017/S0022215100065208 Chang P, 1998, LARYNGOSCOPE, V108, P599, DOI 10.1097/00005537-199804000-00025 Couloigner V, 2004, ACTA OTO-LARYNGOL, V124, P449, DOI 10.1080/00016480310000700 Devaney KO, 2003, ACTA OTO-LARYNGOL, V123, P1022, DOI 10.1080/00016480310000494 FRIEDMANN I, 1959, Ann Otol Rhinol Laryngol, V68, P57 GOYCOOLEA MV, 1980, LARYNGOSCOPE, V90, P2037, DOI 10.1288/00005537-198012000-00015 Hansen MR, 2004, LARYNGOSCOPE, V114, P1470, DOI 10.1097/00005537-200408000-00028 Jackler RK, 2003, OTOL NEUROTOL, V24, P96, DOI 10.1097/00129492-200301000-00020 Kosling S, 2001, EUR J RADIOL, V40, P113, DOI 10.1016/S0720-048X(01)00379-5 Lonser RR, 2004, NEW ENGL J MED, V350, P2481, DOI 10.1056/NEJMoa040666 MAIN TS, 1970, ARCHIV OTOLARYNGOL, V91, P356 Megerian CA, 2002, OTOL NEUROTOL, V23, P378, DOI 10.1097/00129492-200205000-00026 Salt AN, 2001, ANN NY ACAD SCI, V942, P306 NR 13 TC 1 Z9 1 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0385-8146 J9 AURIS NASUS LARYNX JI Auris Nasus Larynx PD MAR PY 2007 VL 34 IS 1 BP 95 EP 100 DI 10.1016/j.anl.2006.05.016 PG 6 WC Otorhinolaryngology SC Otorhinolaryngology GA 139CK UT WOS:000244409500017 PM 16914280 ER PT J AU Sonmez, G Basekim, CC Ozturk, E Gungor, A Kizilkaya, E AF Sonmez, Guner Basekim, C. Cinar Ozturk, Ersin Gungor, Atilla Kizilkaya, Esref TI Imaging of pulsatile tinnitus: a review of 74 patients SO CLINICAL IMAGING LA English DT Review DE pulsatile tinnitus; Doppler US; HRCT; DSA; MRI ID TEMPORAL BONE; ANGIOGRAPHY; SINUS AB Objective: Our aim was to assess the effectiveness of imaging modalities in detecting the underlying pathologies in patients with pulsatile tinnitus. Materials and Methods: Seventy-four patients with pulsatile tinnitus were radiologically evaluated. All patients except two are evaluated on a thin-section bone algorithm computed tomography scan covering the temporal bone and skull base, 14 patients with or without contrast-enhanced brain computed tomography, 7 patients with magnetic resonance imaging and magnetic resonance angiography, 5 patients with digital subtraction angiography, and 12 patients with Doppler ultrasonography. Results: The underlying pathology of tinnitus was detected in 50 patients (67.6%), and 24 patients were normal with radiologic studies. The most common cause was high jugular bulbus (21%) followed by atherosclerosis, dehiscent jugular bulbus, aneurysm of internal carotid artery, dural arteriovenous fistula, aberrant internal carotid artery, jugular diverticulum, and glomus tumor. Conclusion: It was concluded that. radiologic imaging methods are effective in detecting the underlying pathology of pulsatile tinnitus. (C) 2007 Elsevier Inc. All rights reserved. C1 GATA Haydarpasa Teaching Hosp, Dept Radiol, TR-81327 Istanbul, Turkey. GATA Haydarpasa Teaching Hosp, Dept Otolaryngol, TR-81327 Istanbul, Turkey. RP Sonmez, G (reprint author), GATA Haydarpasa Teaching Hosp, Dept Radiol, TR-81327 Istanbul, Turkey. EM gunersonmez@hotmail.com CR BARROW DL, 1985, J NEUROSURG, V62, P248, DOI 10.3171/jns.1985.62.2.0248 Darwish B, 2005, J CLIN NEUROSCI, V12, P601, DOI 10.1016/j.jocn.2004.08.025 DIETZ RR, 1994, AM J NEURORADIOL, V15, P879 Foyt D, 2006, OTOLARYNG HEAD NECK, V134, P701, DOI 10.1016/j.otohns.2005.03.066 HASSO AN, 1994, AM J NEURORADIOL, V15, P890 Hourani R, 2005, J COMPUT ASSIST TOMO, V29, P657, DOI 10.1097/01.rct.0000175499.34213.5d Koesling S, 2005, EUR J RADIOL, V54, P335, DOI 10.1016/j.ejrad.2004.09.003 Lo W W, 1985, Radiographics, V5, P985 LUXON LM, 1993, BRIT MED J, V306, P1490 Marsot-Dupuch K, 2001, SEMIN ULTRASOUND CT, V22, P250, DOI 10.1053/sult.2001.25363 OLSEN WL, 1986, AM J NEURORADIOL, V7, P1039 Patradoon-Ho P, 2006, MED J AUSTRALIA, V185, P279 Pośpiech L, 2000, Otolaryngol Pol, V54 Suppl 31, P112 Prestigiacomo CJ, 2003, AM J NEURORADIOL, V24, P1429 ROY D, 1993, J OTOLARYNGOL, V22, P409 SISMANIS A, 1994, AM J OTOL, V15, P404 WADIN K, 1986, ACTA RADIOL DIAGN, V27, P295 Weissman JL, 1996, RADIOLOGY, V199, P593 Weissman JL, 2000, RADIOLOGY, V216, P342 Weissman JL, 1998, AM J NEURORADIOL, V19, P119 NR 20 TC 32 Z9 39 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0899-7071 J9 CLIN IMAG JI Clin. Imaging PD MAR-APR PY 2007 VL 31 IS 2 BP 102 EP 108 DI 10.1016/j.clinimag.2006.12.024 PG 7 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA 144SG UT WOS:000244815800004 PM 17320776 ER PT J AU Smerz, RW AF Smerz, Richard W. TI A descriptive epidemiological analysis of isolated inner ear decompression illness in recreational divers in Hawaii SO DIVING AND HYPERBARIC MEDICINE LA English DT Article DE decompression illness; decompression sickness. inner ear decompression illness; inner ear decompression sickness; treatment; epidemiology ID TO-LEFT SHUNT; COMPRESSED-AIR; SICKNESS AB Inner ear decompression illness (IEDCI) was once thought to be relatively rare and seen predominantly in deep, mixed-gas divers. The incidence of this type of injury is unknown, but IEDCI may be more common than previously thought and can be seen in recreational scuba divers using compressed air as their breathing medium. This study was conducted at the Hyperbaric Treatment Center (HTC) in Honolulu, Hawaii, to determine the frequency of occurrence of IEDCI and to evaluate some of the epidemiological parameters associated with these cases. Between 1983 and 2006, 28 presentations (2.8% of all cases of decompression illness treated) with a diagnosis of isolated IEDCI were identified in 26 divers. Presenting symptoms and physical findings included vertigo, nausea, postural imbalance, vomiting, nystagmus, hearing loss, and tinnitus. Most cases developed after multiple deep dives or after dives in which adequate decompression did not occur. All but two divers were breathing air. Symptoms developed on average 70 minutes after diving. The average delay to treatment was nine hours post injury. All but three cases were treated using the HTC deep treatment tables. Nineteen cases made a full recovery, with all cases achieving substantial improvement. Most cases required four to five treatments to obtain that level of recovery. Those with incomplete resolution of symptoms at the time of discharge were left with mild degrees of motion sickness and gait disturbance, and some were left with hearing loss. IEDCI warrants early and aggressive intervention to reduce the risk of permanent disability. C1 Univ Hawaii, John A Burns Sch Med, Hyperbar Treatment Ctr, Honolulu, HI 96817 USA. RP Smerz, RW (reprint author), Univ Hawaii, John A Burns Sch Med, Hyperbar Treatment Ctr, 347 N Kuakini St, Honolulu, HI 96817 USA. EM rsmerz@htchawaii.com CR Buhlmann AA, 1976, UNDERWATER PHYSL, P341 Cantais E, 2003, CRIT CARE MED, V31, P84, DOI 10.1097/01.CCM.0000038040.42972.81 Doolette DJ, 2003, J APPL PHYSIOL, V94, P2145, DOI 10.1152/japplphysiol.01090.2002 EDMONDS C, 2002, DIVING SUBAQUATIC ME, P145 Edmonds C, 2004, SPUMS J, V34, P2 EDMONDS C, 2002, DIVING SUBAQUATIC ME, P379 Edmonds C, 2002, DIVING SUBAQUATIC ME, P73 FARMER JC, 1984, PHYSICIANS GUIDE DIV, P192 FARMER JC, 1976, LARYNGOSCOPE, V86, P1315, DOI 10.1288/00005537-197609000-00003 FARMER JC, 1993, PHYSL MED DIVING, P285 FARMER JC, 1984, PHYS GUIDE DIVING ME, P312 Germonpre P, 1998, J APPL PHYSIOL, V84, P1622 Hotson JR, 1998, NEW ENGL J MED, V339, P680, DOI 10.1056/NEJM199809033391007 KENNEDY RS, 1970, AVIAT SPACE ENV MED, V46, P432 Klingmann C, 2003, LARYNGOSCOPE, V113, P1356, DOI 10.1097/00005537-200308000-00017 LAMBERTSEN CJ, 1975, J APPL PHYSIOL, V39, P434 Nachum Z, 2001, LARYNGOSCOPE, V111, P851, DOI 10.1097/00005537-200105000-00018 REISSMAN P, 1990, AVIAT SPACE ENVIR MD, V61, P563 RUBENSTEIN CJ, 1971, UNDERWATER PHYSL, V4, P287 Satoh M, 1992, Nihon Jibiinkoka Gakkai Kaiho, V95, P499 SHUPAK A, 1991, LARYNGOSCOPE, V101, P173 Smerz RW, 2005, UNDERSEA HYPERBAR M, V32, P363 SMITH AH, 1873, EFFECTS HIGH ATMOSPH, P1 Vail HH, 1929, ARCHIV OTOLARYNGOL, V10, P113 Wong R, 2004, SPUMS J, V34, P5 NR 25 TC 2 Z9 2 PU SOUTH PACIFIC UNDERWATER MED SOC PI MELBOURNE PA C/O AUSTRALIAN & NEW ZEALAND COLL ANAESTHETISTS, 630 ST KILDA RD, MELBOURNE, VIC 3004, AUSTRALIA SN 1833-3516 J9 DIVING HYPERB MED JI Diving Hyperb. Med. PD MAR PY 2007 VL 37 IS 1 BP 2 EP 9 PG 8 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 314UR UT WOS:000256835200002 ER PT J AU Savastano, M Marioni, G Aita, M AF Savastano, Marina Marioni, Gino Aita, Maria TI Psychological characteristics of patients with Meniere's disease compared with patients with vertigo, tinnitus, or hearing loss SO ENT-EAR NOSE & THROAT JOURNAL LA English DT Article ID PANIC DISORDER; DIZZINESS; SYMPTOMS; HEALTH; LIFE; MANAGEMENT; DISABILITY; SUFFERERS; DISTRESS; STRESS AB An association between Meniere's disease and psychological distress is frequently reported. Patients who do not have Meniere's disease but who have similar symptoms also experience various kinds of psychological disturbances. We conducted a study to investigate the relationship between Meniere's disease and personality traits, illness behavior depression, and anxiety. We compared these factors in 77 patients who had Meniere's disease and 133 controls who did not have the disease but had one of its symptoms-either vertigo, tinnitus, or hearing loss. The mental status of study participants was assessed with standard tests. Patients in both groups had higher than normal levels of anxiety and neuroticism. The only significant difference between the two groups was a higher rate of extroversion in the Meniere's disease group. Minor differences emerged when Meniere's patients with tinnitus or vertigo were compared with similar controls. Relationships between psychological observations and otologic symptomatology or an otologic diagnosis were not specific, which illustrates the need to consider the role of illness behavior and personality as targets for psychological support or therapy associated with ENT treatment. C1 Padova Univ Hosp, ENT Sect, Dept Med Surg Specialities, I-35128 Padua, Italy. RP Savastano, M (reprint author), Padova Univ Hosp, ENT Sect, Dept Med Surg Specialities, Via Giustiniani 2, I-35128 Padua, Italy. EM marina.savastano@unipd.it CR Anderson D C, 1995, J Am Optom Assoc, V66, P545 Andersson G, 1997, J PSYCHOSOM RES, V43, P595, DOI 10.1016/S0022-3999(97)00184-0 Asmundson GJG, 1998, J PSYCHOSOM RES, V44, P107, DOI 10.1016/S0022-3999(97)00132-3 Celestino D, 2003, Acta Otorhinolaryngol Ital, V23, P421 CLARK DB, 1994, AM J PSYCHIAT, V151, P1223 CRARY WG, 1977, PSYCHOL REP, V41, P603 Dineen R, 1997, BRIT J AUDIOL, V31, P27, DOI 10.3109/03005364000000006 ERIKSSONMANGOLD M, 1991, J PSYCHOSOM RES, V35, P729, DOI 10.1016/0022-3999(91)90124-7 EYSENCK HJ, 1990, MANUAL EYSENCK PERSO Eysenck HJ, 1975, MANUAL EYSENCK PERSO Fung K, 2002, J OTOLARYNGOL, V31, P1, DOI 10.2310/7070.2002.19261 Furman JM, 1997, NEUROLOGY, V48, P1161 GRIMBY A, 1995, GERONTOLOGY, V41, P286 Hagnebo C, 1997, SCAND AUDIOL, V26, P69, DOI 10.3109/01050399709074978 Hiller W, 1997, J PSYCHOSOM RES, V43, P613, DOI 10.1016/S0022-3999(97)00188-8 Horner K C, 2003, Noise Health, V5, P29 Horner KC, 2005, BRAIN RES BULL, V66, P1, DOI 10.1016/j.brainresbull.2005.04.003 Klar J, 2006, AM J MED GENET B, V141B, P463, DOI 10.1002/ajmg.b.30347 Martin C, 1991, Rev Laryngol Otol Rhinol (Bord), V112, P109 Meric C, 1998, AUDIOL NEURO-OTOL, V3, P240, DOI 10.1159/000013796 Morrison AW, 2002, OTOLARYNG CLIN N AM, V35, P497, DOI 10.1016/S0030-6665(02)00018-X Ormel J, 1997, PSYCHOL MED, V27, P1065, DOI 10.1017/S0033291797005321 PIERFEDERICI A, 1982, NUOVI METODI PSICOME PILOWSKI I, 1983, MANUAL ILLNESS BEHAV Rizzardo R, 1998, J OTOLARYNGOL, V27, P21 Savastano M, 1996, J OTOLARYNGOL, V25, P329 Simon N M, 1998, Ann Clin Psychiatry, V10, P75, DOI 10.3109/10401239809147746 Szirmai Agnes, 2005, Int Tinnitus J, V11, P77 Ursin H, 1997, BEHAV BRAIN SCI, V20, P469 Visentin P, 1998, ARCH GERONTOL GERIAT, V26, P247, DOI 10.1016/S0167-4943(98)00007-7 Wise K, 1998, J PSYCHOSOM RES, V44, P681, DOI 10.1016/S0022-3999(97)00310-3 Yardley L, 2001, J NERV MENT DIS, V189, P321, DOI 10.1097/00005053-200105000-00009 NR 32 TC 8 Z9 9 PU VENDOME GROUP LLC PI NEW YORK PA 6 EAST 32 ST, 8 FLOOR, NEW YORK, NY 10016 USA SN 0145-5613 J9 ENT-EAR NOSE THROAT JI ENT-Ear Nose Throat J. PD MAR PY 2007 VL 86 IS 3 BP 148 EP 156 PG 9 WC Otorhinolaryngology SC Otorhinolaryngology GA 156GO UT WOS:000245636300011 PM 17427776 ER PT J AU Limberger, A Beck, M Delgado-Sanchez, S Keilmann, A AF Limberger, A. Beck, M. Delgado-Sanchez, S. Keilmann, A. TI Hearing loss in patients with Fabry disease SO HNO LA German DT Article DE M. Fabry; lysosomal storage disease; hearing loss; tinnitus; women ID CLINICAL-MANIFESTATIONS; REPLACEMENT THERAPY AB Background: Fabry disease is an X-linked lysosomal storage disease involving deficient activity of alpha-galactosidase A, which leads initially to pain, and later to renal insufficiency, cardiomyopathy and stroke. Until now few details are available on hearing impairment in patients with Fabry disease, and especially few relating to female patients. Patients and Methods: We examined 43 female and 29 male patients. In this study we looked into the question of whether and to what extent patients of both genders are affected by hearing impairment. Results: Hearing loss is characteristic being more severe at high frequencies frequencies. Overall, 22 female and 15 male patients were found to have suffered a hearing loss. Patients with severe symptoms of Fabry disease usually demonstrate more prominent hearing losses. Conclusions: Both men and women with Fabry disease are affected by hearing impairment. It seems that the hearing loss is less marked in female than in male patients. Children with Fabry disease complain of tinnitus more frequently than other children and quite early in the course of the disease. C1 Univ Mainz Klinikum, Klin HNO & Kommunikat, D-55101 Mainz, Germany. Univ Klin Mainz, Kinderklin & Poliklin, Mainz, Germany. RP Limberger, A (reprint author), Univ Mainz Klinikum, Klin HNO & Kommunikat, Langenbeckstr 1, D-55101 Mainz, Germany. EM limberger@kommunikation.klinik.uni-mainz.de CR CONTI G, 2003, ACTA PAEDIATR, V443, P33 Garman SC, 2004, J MOL BIOL, V337, P319, DOI 10.1016/j.jmb.2004.01.035 GERMAIN DP, 2002, BMC MED GENET, V439, P138 Hajioff D, 2003, J INHERIT METAB DIS, V26, P787, DOI 10.1023/B:BOLI.0000009948.86528.72 KEILMANN A, 2003, ACTA PAEDIATR, V443, P31 MacDermot KD, 2001, J MED GENET, V38, P750, DOI 10.1136/jmg.38.11.750 Mehta A, 2004, EUR J CLIN INVEST, V34, P236, DOI 10.1111/j.1365-2362.2004.01309.x SCHACHERN PA, 1989, ANN OTO RHINOL LARYN, V98, P359 Stavroulaki P, 2001, CLIN OTOLARYNGOL, V26, P235, DOI 10.1046/j.0307-7772.2001.00464.x Whybra C, 2004, CLIN GENET, V65, P299, DOI 10.1111/j.1399-0004.2004.00219.x NR 10 TC 3 Z9 3 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013 USA SN 0017-6192 J9 HNO JI HNO PD MAR PY 2007 VL 55 IS 3 BP 185 EP 189 DI 10.1007/s00106-006-1454-z PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA 142YO UT WOS:000244687400006 PM 17004069 ER PT J AU Plewnia, C Reimold, M Najib, A Brehm, B Reischl, G Plontke, SK Gerloff, C AF Plewnia, Christian Reimold, Matthias Najib, Arif Brehm, Bernhard Reischl, Gerald Plontke, Stefan K. Gerloff, Christian TI Dose-dependent attenuation of auditory phantom perception (tinnitus) by PET-guided repetitive transcranial magnetic stimulation SO HUMAN BRAIN MAPPING LA English DT Article DE positron emission tomography; auditory cortex; auditory pathways; neuronal plasticity; neuronavigation; parietal lobe; temporal lobe; cerebral cortex ID MOTOR CORTEX EXCITABILITY; LOW-FREQUENCY RTMS; PARKINSONS-DISEASE; CORTICOSPINAL EXCITABILITY; FUNCTIONAL NEUROANATOMY; DOUBLE-BLIND; HALLUCINATIONS; DEPRESSION; PLASTICITY; REORGANIZATION AB Recent data suggest that chronic tinnitus is a "phantom auditory perception" caused by maladaptive neuroplasticity and subsequent hyperactivity in an extended neuronal network including the primary auditory cortex, higher-order association areas, and parts of the limbic system. It was suggested that attenuation of this tinnitus-associated hyperactivity may offer a rational option for lasting tinnitus reduction. Here, we tested the hypothesis that tinnitus loudness can be attenuated by low-frequency repetitive transcranial magnetic stimulation (rTMS) individually navigated to cortical areas with excessive tinnitus-related activity as assessed by [(15)O]H(2)O positron-emission tomography (PET). Nine patients with chronic tinnitus underwent this combined functional imaging and rTMS-study. Group analysis of the PET data showed tinnitus-related increases of regional cerebral blood flow in the left middle and inferior temporal as well as right temporoparietal cortex and posterior cingulum. Repetitive TMS was performed at 1 Hz and 120% of the motor threshold for 5, 15, and 30 min, navigated to the individual maximum of tinnitus-related cortical hyperactivity. A noncortical stimulation site with the same distance to the ear served as sham control. Tinnitus loudness was reduced after temporoparietal, PET-guided low-frequency rTMS. This reduction, lasting up to 30 min, was dependent on the number of stimuli applied, differed from sham stimulation, and was negatively correlated with the length of the medical history of tinnitus in our patients. These data show the feasibility and effectiveness of rTMS guided by individual functional imaging to induce a lasting, dose-dependent attenuation of tinnitus. Of note, these effects were related to stimulation of cortical association areas, not primary auditory cortex, emphasizing the crucial role of higher-order sensory processing in the pathophysiology of chronic tinnitus. C1 Univ Hamburg, Med Ctr, Dept Neurol, D-20246 Hamburg, Germany. Univ Tubingen, Dept Psychiat, Neurophysiol Sect, D-7400 Tubingen, Germany. Univ Tubingen, Dept Nucl Med, PET Ctr, D-7400 Tubingen, Germany. Univ Tubingen, Hertie Inst Clin Brain Res, Dept Gen Neurol, Cort Physiol Res Grp, D-7400 Tubingen, Germany. Univ Tubingen, Dept Nucl Med, Radiopharmacol Sect, D-7400 Tubingen, Germany. Univ Tubingen, Dept Otolaryngol Head & Neck Surg, Tubingen Hearing Res Ctr, D-7400 Tubingen, Germany. RP Gerloff, C (reprint author), Univ Hamburg, Med Ctr, Dept Neurol, Martinistr 52, D-20246 Hamburg, Germany. 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Brain Mapp. PD MAR PY 2007 VL 28 IS 3 BP 238 EP 246 DI 10.1002/hbm.20270 PG 9 WC Neurosciences; Neuroimaging; Radiology, Nuclear Medicine & Medical Imaging SC Neurosciences & Neurology; Radiology, Nuclear Medicine & Medical Imaging GA 136YD UT WOS:000244259100008 PM 16773635 ER PT J AU Davidson, HC Lutman, ME AF Davidson, Harry C. Lutman, Mark E. TI Survey of mobile phone use and their chronic effects on the hearing of a student population SO INTERNATIONAL JOURNAL OF AUDIOLOGY LA English DT Article; Proceedings Paper CT 1st Conference on Noise-Induced Hearing Loss in Children at Work and Play CY OCT 19-20, 2006 CL Covington, KY SP Natl Inst for Occupational Safety & Hlth, Natl Inst Deafness & Commun Disorders, Natl Hearing Conservation Assoc, Mation Downs Hearing Ctr, Oregon Hlth & Science Univ, Univ No Colorado DE mobile phone; questionnaire; hearing; tinnitus; balance ID CELLULAR PHONES; RADIATION; SYMPTOMS; RISK AB Mobile phone ownership and usage is now widespread and public concern has developed over possible harmful physiological effects of their use. This study aimed to investigate the prevalence of student mobile phone ownership and any possible chronic effects of usage on hearing, tinnitus and balance. Questionnaires for electronic self-completion were distributed to University of Southampton postgraduates, and 117 out of 160 returned met the criteria for analysis. A total of 94% were current mobile phone users, and only 2% had never used a mobile phone. Duration of ownership and daily usage ranged from 0-7 years and 0-45 minutes respectively. Text-messaging was more popular than talking. High or long-term users reported no worse hearing, tinnitus, or balance than low or short-term users. The results of this study confirm that the prevalence of mobile phone ownership amongst students is extremely high. However there appear to be no harmful effects of mobile phone usage on their audiovestibular systems within the range of exposure of the study, insofar as can be detected by the self-report method employed. C1 Univ Southampton, Inst Sound & Vibrat Res, Southampton SO17 1BJ, Hants, England. RP Davidson, HC (reprint author), Univ Southampton, Inst Sound & Vibrat Res, Univ Rd, Southampton SO17 1BJ, Hants, England. EM mel@isvr.soton.ac.uk CR Ahlbom A, 1999, INT J ONCOL, V15, P1045 Ahlbom A, 2003, BRIT MED BULL, V68, P157, DOI 10.1093/bmb/ldg030 Arai N, 2003, CLIN NEUROPHYSIOL, V114, P1390, DOI 10.1016/S1388-2457(03)00124-X Bak Marek, 2003, Int J Occup Med Environ Health, V16, P201 BALIKCI K, 2004, PATHOL BIOL, V53, P30 BOICE JD, 2002, 200216 SSI SWED RAD Elwood J Mark, 2003, Bioelectromagnetics, VSuppl 6, pS63 Gatehouse S, 1999, Health Bull (Edinb), V57, P424 Janssen T, 2005, J ACOUST SOC AM, V117, P1241, DOI [10.1121/1.1854331, 10.1121/1.1854311] LUTMAN M E, 1987, British Journal of Audiology, V21, P45, DOI 10.3109/03005368709077774 Monnery PM, 2004, CLIN OTOLARYNGOL, V29, P747, DOI 10.1111/j.1365-2273.2004.00877.x Noble W., 1978, ASSESSMENT IMPAIRED Ozturan O, 2002, ACTA OTO-LARYNGOL, V122, P289, DOI 10.1080/000164802753648178 PARAZZINI M, 2005, HEAR RES, V26 Sandstrom M, 2001, OCCUP MED-OXFORD, V51, P25, DOI 10.1093/occmed/51.1.25 Santini R, 2001, PATHOL BIOL, V49, P222, DOI 10.1016/S0369-8114(01)00132-8 Schoemaker MJ, 2005, BRIT J CANCER, V93, P842, DOI 10.1038/sj.bjc.6602764 ULOZIENE I, 2005, BMC PUBLIC HEALTH, V19, P39 NR 18 TC 15 Z9 19 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 1499-2027 J9 INT J AUDIOL JI Int. J. Audiol. PD MAR PY 2007 VL 46 IS 3 BP 113 EP 118 DI 10.1080/14992020600690472 PG 6 WC Audiology & Speech-Language Pathology; Otorhinolaryngology SC Audiology & Speech-Language Pathology; Otorhinolaryngology GA 159KL UT WOS:000245864500002 PM 17365064 ER PT J AU Berjis, N Sonbolestan, SM Nemati, S Mokhtarinejad, F Danesh, Z Abdeyazdan, Z AF Berjis, Nezameddin Sonbolestan, Seied Mahdi Nemati, Shadman Mokhtarinejad, Farhad Danesh, Zahra Abdeyazdan, Zahra TI Otorhinolaryngologic manifestations in thalassemia major patients SO IRANIAN JOURNAL OF PEDIATRICS LA English DT Article DE thalassemia major; desferrioxamine; temporomandibular joint; bony deformities; epistaxis; hearing loss AB Objective: In thalassemia major, extramedulary hematopoiesis results in bony deformities such as sever malocclusion in the head and neck, delayed pneumatization of paranasal sinuses and so on. Also, there are many systemic and iatrogenic problems that may affect the head and neck region. The purpose of this study was to determine otorhinolaryngologic manifestations as clinical diseases in thalassemia major patients. Material & Methods: In a cross sectional study 190 thalassemia major patients were evaluated (by history and physical examination) for snoring, epistaxis, nasal obstruction, sinusitis, temporomandibular joint (TMJ) pain and TMJ dislocation, tinnitus and hearing loss. Radiological studies of the skull and paranasal sinuses and audiological tests were performed. The data was analyzed in different age groups with chi(2) test. Findings: Relative frequency of some otorhinolaryngologic manifestations in this population was high. The differences between some clinical diseases as TMJ pain, and epistaxis in different age groups were statistically significant. Conclusion: Thalassemia major increases some clinical diseases in the Otolarygology field. With early diagnosis and early treatment many of them may be prevented. C1 [Berjis, Nezameddin; Sonbolestan, Seied Mahdi] Isfahan Univ Med Sci, Dept Head & Neck Surg, Esfahan, Iran. [Abdeyazdan, Zahra] Isfahan Univ Med Sci, Nursing & Midwifery Fac, Esfahan, Iran. RP Berjis, N (reprint author), Isfahan Univ Med Sci, Alzahra Hosp, Dept Otolaryngol Head & Neck Surg, Esfahan, Iran. EM berjis@med.mui.ac.ir CR BESA EC, 1992, HEMATOLOGY, P115 BORGNAPIGNATTI C, 2004, WINTROBES CLIN HEMAT, P1319 LINKER CA, 1997, CURRENT MED DIAGNOSI, P466 QUESENBERRY PJ, 2001, DISORDERS HEMMATOPOI, V104, P666 ROLAND JT, 1998, CUMMINGS OTOLARYNGOL, P3192 Styles LA, 1996, J PEDIAT HEMATOL ONC, V18, P42, DOI 10.1097/00043426-199602000-00008 WEATHERALL DJ, 2001, HEMATOLOGY, P561 NR 7 TC 1 Z9 1 PU TEHRAN UNIV MEDICAL SCIENCES PI TEHRAN PA P O BOX 14155-6451, TEHRAN, 00000, IRAN SN 1018-4406 J9 IRAN J PEDIATR JI Iran. J. Pediatr. PD MAR PY 2007 VL 17 IS 1 BP 15 EP 18 PG 4 WC Pediatrics SC Pediatrics GA 325NL UT WOS:000257595500003 ER PT J AU Brozoski, TJ Spires, TJD Bauer, CA AF Brozoski, Thomas J. Spires, T. Joseph D. Bauer, Carol A. TI Vigabatrin, a GABA transaminase inhibitor, reversibly eliminates tinnitus in an animal model SO JARO-JOURNAL OF THE ASSOCIATION FOR RESEARCH IN OTOLARYNGOLOGY LA English DT Article DE tinnitus; vigabatrin; GABA; animal model ID SALICYLATE-INDUCED TINNITUS; DORSAL COCHLEAR NUCLEUS; RAT INFERIOR COLLICULUS; HEARING-LOSS; IN-VIVO; GABAPENTIN; SENSATION; EXPOSURE; ABLATION; SYSTEM AB Animal models have facilitated basic neuroscience research investigating the pathophysiology of tinnitus. It has been hypothesized that partial deafferentation produces a loss of tonic inhibition in the auditory system that may lead to inappropriate neuroplastic changes eventually expressed as tinnitus. The pathological down-regulation of gamma-amino butyric acid (GABA) provides a potential mechanism for this loss of inhibition. Using an animal model previously demonstrated to be sensitive to treatments that either induce or attenuate tinnitus, the present study examined the effect of the specific GABA agonist vigabatrin on chronic tinnitus. It was hypothesized that vigabatrin would decrease the evidence of tinnitus by restoring central inhibitory function through increased GABA availability. Vigabatrin has been demonstrated to elevate central GABA levels (Mattson et al. 1995). Tinnitus was induced in rats using a single 1-h unilateral exposure to band-limited noise, which preserved normal hearing in one ear. Psychophysical evidence of tinnitus was obtained using a free-operant conditioned-suppression method: Rats lever-pressed for food pellets and were trained to discriminate between the presence and absence of sound by punishing lever pressing with a mild foot shock (0.5 mA; 1 s) at the conclusion of randomly introduced silent periods (60 s) inserted into background low-level noise. Additional random insertion of pure tone and noise periods of variable intensity enabled the derivation of psychophysical functions that reflected the presence of tinnitus with features similar to 20-kHz tones. Vigabatrin was chronically administered via drinking water at 30 and 81 mg kg(-1) day(-1), with each dose level tested over 2 weeks, followed by a 0-mg washout test. Vigabatrin completely and reversibly eliminated the psychophysical evidence of tinnitus at both doses. 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J. Phillips, J. S. TI Tinnitus SO JOURNAL OF LARYNGOLOGY AND OTOLOGY LA English DT Review DE ear diseases; tinnitus ID PLACEBO-CONTROLLED TRIAL; VASCULAR-DECOMPRESSION SURGERY; CUTANEOUS-EVOKED TINNITUS; DOUBLE-BLIND CROSSOVER; LOW-POWER LASER; SUBJECTIVE TINNITUS; PULSATILE TINNITUS; DISABLING TINNITUS; BOTULINUM-TOXIN; GINKGO-BILOBA AB Chronic idiopathic subjective tinnitus is a common condition affecting around one in ten of the population at any given time. For the majority of people it is an annoyance rather than a major health issue but for approximately 0.5 per cent of the population tinnitus interferes with their ability to pursue a normal life. Modern theories of the pathogenesis of the condition concentrate on the central auditory system although the peripheral auditory system can be a trigger or ignition site for tinnitus. 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A., 1996, P 5 INT TINN SEM 199, P51 Vernon JA, 2003, OTOLARYNG CLIN N AM, V36, P307, DOI 10.1016/S0030-6665(02)00163-9 WALGER M, 1998, TINNITUS TREATMENT R, P68 Westerberg BD, 1996, AM J OTOL, V17, P896 Zachriat Claudia, 2004, Cognitive Behaviour Therapy, V33, P187, DOI 10.1080/16506070410029568 Zenner H P, 2001, Int Tinnitus J, V7, P40 NR 93 TC 11 Z9 15 PU CAMBRIDGE UNIV PRESS PI CAMBRIDGE PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND SN 0022-2151 J9 J LARYNGOL OTOL JI J. Laryngol. Otol. PD MAR PY 2007 VL 121 IS 3 BP 201 EP 208 DI 10.1017/S0022215106002714 PG 8 WC Otorhinolaryngology SC Otorhinolaryngology GA 224YO UT WOS:000250484500001 PM 16995967 ER PT J AU Parra, LC Pearlmutter, BA AF Parra, Lucas C. Pearlmutter, Barak A. TI Illusory percepts from auditory adaptation SO JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA LA English DT Article ID CONTRAST GAIN-CONTROL; BASILAR-MEMBRANE NONLINEARITY; SHORT-TERM ADAPTATION; INFERIOR COLLICULUS; NERVE FIBERS; HEARING-LOSS; ELECTRICAL-STIMULATION; GUINEA-PIG; HAIR-CELL; OTOACOUSTIC EMISSION AB Phenomena resembling tinnitus and Zwicker phantom tone are seen to result from an auditory gain adaptation mechanism that attempts to make full use of a fixed-capacity channel. In the case of tinnitus, the gain adaptation enhances internal noise of a frequency band otherwise silent due to damage. This generates a percept of a phantom sound as a consequence of hearing loss. In the case of Zwicker tone, a frequency band is temporarily silent during the presentation of a notched broadband sound, resulting in a percept of a tone at the notched frequency. The model-suggests a link between tinnitus and the Zwicker tone percept, in that it predicts different results for normal and tinnitus subjects due to a loss of instantaneous nonlinear compression. Listening experiments on 44 subjects show that tinnitus subjects (11 of 44) are significantly more likely to hear the Zwicker tone. This psychoacoustic experiment establishes the first empirical link between the Zwicker tone percept and tinnitus. Together with the modeling results, this supports the hypothesis that the phantom percept is a consequence of a central adaptation mechanism confronted with a degraded sensory apparatus. (c) 2007 Acoustical Society of America. C1 CUNY City Coll, Dept Biomed Engn, New York, NY 10031 USA. Nat Univ Ireland, Hamilton Inst, Maynooth, Kildare, Ireland. RP Parra, LC (reprint author), CUNY City Coll, Dept Biomed Engn, New York, NY 10031 USA. 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Acoust. Soc. Am. PD MAR PY 2007 VL 121 IS 3 BP 1632 EP 1641 DI 10.1121/1.2431346 PG 10 WC Acoustics; Audiology & Speech-Language Pathology SC Acoustics; Audiology & Speech-Language Pathology GA 147VT UT WOS:000245031600039 PM 17407900 ER PT J AU Jerger, J AF Jerger, James TI Does tinnitus actually affect quality of life? SO JOURNAL OF THE AMERICAN ACADEMY OF AUDIOLOGY LA English DT Editorial Material C1 Univ Texas, Richardson, TX 75080 USA. RP Jerger, J (reprint author), Univ Texas, Richardson, TX 75080 USA. NR 0 TC 0 Z9 0 PU AMER ACADEMY OF AUDIOLOGY PI RESTON PA 11730 PLAZA DRIVE, STE 300, RESTON, VA 20190 USA SN 1050-0545 J9 J AM ACAD AUDIOL JI J. Am. Acad. Audiol. PD MAR PY 2007 VL 18 IS 3 BP 196 EP 196 PG 1 WC Audiology & Speech-Language Pathology; Otorhinolaryngology SC Audiology & Speech-Language Pathology; Otorhinolaryngology GA 156KW UT WOS:000245647800001 PM 17479612 ER PT J AU Steiger, JR Saccone, PA Watson, KN AF Steiger, James R. Saccone, Patricia A. Watson, Karen N. TI Assessment of objective pulsatile tinnitus in a patient with syringohydromyelia SO JOURNAL OF THE AMERICAN ACADEMY OF AUDIOLOGY LA English DT Article DE intracranial hypertension; objective tinnitus; pulsatile tinnitus; syringohydromyelia ID BENIGN INTRACRANIAL HYPERTENSION; PSEUDOTUMOR CEREBRI; MINOCYCLINE; TETRACYCLINE; SYMPTOMS; SYRINGOMYELIA; MALFORMATION; DIAGNOSIS; DISEASE AB We examined a 38-year-old male with syringohydromyelia and concomitant symptoms suggestive of intracranial hypertension including unilateral low-frequency sensorineural hearing loss and objective pulsatile tinnitus. The tinnitus was heard by the authors (through a hearing aid stethoscope tube), measured objectively (with a probe microphone), measured subjectively (as minimum masking levels and with fixed frequency Bekesy), and altered by changes in ear canal pressure (subjectively reported and measured objectively with a probe microphone). The audiologic symptoms were likely associated with elevated cerebrospinal fluid pressure that traveled to the cochlea through the cochlear aqueduct. The tinnitus may have originated from pulsations of central vascular structures that traveled through the cochlear aqueduct or the endolymphatic duct. Hearing loss likely resulted from tinnitus masking or a stiffening of the cochlear partition or stapes footplate. C1 Univ Akron, Sch Speech Language Pathol & Audiol, Akron, OH 44325 USA. RP Steiger, JR (reprint author), Univ Akron, Sch Speech Language Pathol & Audiol, Polsky Bldg 181, Akron, OH 44325 USA. 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Am. Acad. Audiol. PD MAR PY 2007 VL 18 IS 3 BP 197 EP 205 DI 10.3766/jaaa.18.3.2 PG 9 WC Audiology & Speech-Language Pathology; Otorhinolaryngology SC Audiology & Speech-Language Pathology; Otorhinolaryngology GA 156KW UT WOS:000245647800002 PM 17479613 ER PT J AU Nondahl, DM Cruickshanks, KJ Dalton, DS Klein, BEK Klein, R Schubert, CR Tweed, TS Wiley, TL AF Nondahl, David M. Cruickshanks, Karen J. Dalton, Dayna S. Klein, Barbara E. K. Klein, Ronald Schubert, Carla R. Tweed, Ted S. Wiley, Terry L. TI The impact of tinnitus on quality of life in older adults SO JOURNAL OF THE AMERICAN ACADEMY OF AUDIOLOGY LA English DT Article DE hearing disorders; quality of life; tinnitus ID HEARING-LOSS; BEAVER DAM; PAIN; EPIDEMIOLOGY; PREVALENCE AB Few population-based data exist to assess the impact of tinnitus on quality of life. As part of the Epidemiology of Hearing Loss Study, self-reported data on tinnitus and quality of life were obtained by interview at the first follow-up examination (1998-2000; N = 2800; ages 53-97 years). The Medical Outcomes Study Short Form Health Survey (SF-36) was used to assess quality of life. Adjusted mean SF-36 scores decreased (worsened) with increasing tinnitus severity (None, Mild, Moderate, Severe) for the Role-Physical, Bodily Pain, Vitality, and Mental Health domains, and the Physical Component Summary scale (F-tests for linear trend, p < .05). Scores tended to be lower for those who first reported tinnitus at the follow-up (five-year incidence of tinnitus) compared to those who reported tinnitus at the baseline and follow-up examinations (prevalent tinnitus). This study documents clear associations between tinnitus and reduced quality of life in this large cohort of older adults. C1 Univ Wisconsin, Dept Ophthalmol & Visual Sci, Madison, WI 53726 USA. Univ Wisconsin, Dept Populat Hlth Sci, Madison, WI USA. Univ Wisconsin, Dept Commun Disorders, Madison, WI USA. Arizona State Univ, Dept Speech & Hearing Sci, Tempe, AZ USA. RP Nondahl, DM (reprint author), Univ Wisconsin, Dept Ophthalmol & Visual Sci, 610 Walnut St,Room 1040, Madison, WI 53726 USA. EM Nondahl@episense.wisc.edu CR Bauch Christopher D, 2003, J Am Acad Audiol, V14, P181 BRINER W, 1995, PSYCHOL REP, V77, P27 Cruickshanks KJ, 2003, ARCH OTOLARYNGOL, V129, P1041, DOI 10.1001/archotol.129.10.1041 Cruickshanks KJ, 1998, AM J EPIDEMIOL, V148, P879 Dalton DS, 2003, GERONTOLOGIST, V43, P661 DAVIS AC, 1996, P 5 INT TINN SEM 199, P257 Dionne RA, 2005, TRENDS PHARMACOL SCI, V26, P125, DOI 10.1016/j.tips.2005.01.009 Dobie R, 2004, TINNITUS THEORY MANA, P1 Erlandsson SI, 2000, BRIT J AUDIOL, V34, P11, DOI 10.3109/03005364000000114 Folmer RL, 2001, OTOLARYNG HEAD NECK, V124, P394, DOI 10.1067/mhn.2001.114673 HALLAM RS, 1987, TINNITUS, P157 Hoffmann H. 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Am. Acad. Audiol. PD MAR PY 2007 VL 18 IS 3 BP 257 EP 266 DI 10.3766/jaaa.18.3.7 PG 10 WC Audiology & Speech-Language Pathology; Otorhinolaryngology SC Audiology & Speech-Language Pathology; Otorhinolaryngology GA 156KW UT WOS:000245647800007 PM 17479618 ER PT J AU Schick, B Schick, BT Kochannek, S Starlinger, V Iro, H AF Schick, B. Schick, B. T. Kochannek, S. Starlinger, V. Iro, H. TI Temporary sensory hearing deficits after ear surgery - a retrospective analysis SO LARYNGO-RHINO-OTOLOGIE LA German DT Article DE temporary hearing deficit; ear surgery; drill; tinnitus ID OSSICULAR CHAIN INJURY; GENERATED NOISE-LEVELS; THRESHOLD SHIFT; ACOUSTIC TRAUMA; GUINEA-PIGS; DRILL-NOISE; INNER-EAR; METHYLPREDNISOLONE AB Background: Temporary and persistent threshold shifts can occur after ear surgery. So far, only few studies deal with temporary sensory hearing deficits after ear surgery. Patients and methods: In a retrospective study, thresholds at 500 Hz, 1000 Hz, 2000 Hz and 4000 Hz were analysed in 393 patients (125 x mesotympanal chronic otitis media, 164 x cholesteatoma, 44 x tympanosclerosis, 60 x otosclerosis) before, the first 4 days and 3 weeks after ear surgery to evaluate possible temporary threshold shifts. Results: Analysis of all patients in total proved statistically significant slight temporary threshold shifts of up to 7 dB at 2000 Hz (postoperative day 1 to 3) and at 4000 Hz (postoperative day 1 and 2). Use of a drill caused a statistically slight temporary threshold shift only at 2000 Hz at the first postoperative day (4.2 dB). In cholesteatoma surgery with preparations at the ossicular chain a statistically significant slightly higher threshold level was found in all postsurgical evaluations at 500 Hz. Removal of scars or granulation tissue attached to the ossicular chain was not associated with an elevation of threshold levels. Conclusion: Slight temporary threshold shifts can be observed at 2000 Hz and 4000 Hz after ear surgery. Use of the drill and preparation at the ossicular chain usually results in no significant sensory hearing deficit. C1 Univ Erlangen Nurnberg, Hals Nasen Ohren Klin, D-91054 Erlangen, Germany. RP Schick, B (reprint author), Univ Erlangen Nurnberg, Hals Nasen Ohren Klin, Waldstr 1, D-91054 Erlangen, Germany. EM bernhard.schick@hno.imed.uni-erlangen.de CR Chen YS, 2003, ORL J OTO-RHINO-LARY, V65, P266, DOI 10.1159/000075224 daCruz MJ, 1997, OTOLARYNG HEAD NECK, V117, P555, DOI 10.1016/S0194-5998(97)70030-5 Davis R R, 2003, Noise Health, V5, P19 El-Hennawi DM, 2005, J LARYNGOL OTOL, V119, P2 Gjuric M, 1997, ACTA OTO-LARYNGOL, V117, P497, DOI 10.3109/00016489709113427 HEDGEWALD M, 1989, OTOLARYNGOL HEAD NEC, V100, P49 HELMS J, 1976, J LARYNGOL OTOL, V90, P1143, DOI 10.1017/S0022215100083225 HOLMQUIST J, 1979, ACTA OTO-LARYNGOL, V87, P458, DOI 10.3109/00016487909126451 Hsu CJ, 2000, HEARING RES, V142, P203, DOI 10.1016/S0378-5955(00)00020-4 Kopke R, 2005, ACTA OTO-LARYNGOL, V125, P235, DOI 10.1080/00016480410023038 KYLEN P, 1977, ACTA OTO-LARYNGOL, V84, P252, DOI 10.3109/00016487709123964 KYLEN P, 1977, ACTA OTO-LARYNGOL, V84, P393, DOI 10.3109/00016487709123982 KYLEN P, 1980, ARCH OTOLARYNGOL, V106, P598 Nordmann AS, 2000, HEARING RES, V139, P13, DOI 10.1016/S0378-5955(99)00163-X PALVA A, 1979, ACTA OTOLARYNGOL, V87, P155 PALVA T, 1973, ARCH OTOLARYNGOL, V98, P176 PAPARELLA M M, 1962, Laryngoscope, V72, P116 Rask-Andersen H, 2000, HEARING RES, V141, P129, DOI 10.1016/S0378-5955(99)00216-6 Ruel J, 2005, NEUROREPORT, V16, P1087, DOI 10.1097/00001756-200507130-00011 Schneider W, 1998, ACTA OTO-LARYNGOL, V118, P52 SUITS GW, 1993, OTOLARYNG HEAD NECK, V109, P660 Takemura K, 2004, HEARING RES, V196, P58, DOI 10.1016/j.heares.2004.06.003 TOS M, 1989, J LARYNGOL OTOL, V103, P845, DOI 10.1017/S0022215100110278 URQUHART AC, 1992, LARYNGOSCOPE, V102, P689, DOI 10.1288/00005537-199206000-00016 NR 24 TC 2 Z9 3 PU GEORG THIEME VERLAG KG PI STUTTGART PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY SN 0935-8943 J9 LARYNGO RHINO OTOL JI Laryngo-Rhino-Otol. PD MAR PY 2007 VL 86 IS 3 BP 200 EP 205 DI 10.1055/s-2006-944750 PG 6 WC Otorhinolaryngology SC Otorhinolaryngology GA 146PI UT WOS:000244946200007 PM 17131257 ER PT J AU Smith, JA Mennemeier, M Bartel, T Chelette, KC Kimbrell, T Triggs, W Dornhoffer, JL AF Smith, Jason A. Mennemeier, Mark Bartel, Twyla Chelette, Kenneth C. Kimbrell, Timothy Triggs, William Dornhoffer, John L. TI Repetitive transcranial magnetic stimulation for tinnitus: A pilot study SO LARYNGOSCOPE LA English DT Article DE rTMS; Transcranial magnetic stimulation; tinnitus; attention; vigilance; psychomotor vigilance task; positron emission tomography/computed tomography; imaging ID LEFT AUDITORY-CORTEX; PET; SUPPRESSION; DEPRESSION; ACTIVATION; RTMS AB Objectives/Hypothesis: Low-frequency repetitive transcranial magnetic stimulation (rTMS) has been shown to alleviate tinnitus perception, presumably by inhibiting cortical activity associated with tinnitus. We conducted a pilot study to assess effectiveness of neuronavigated rTMS and its effects on attentional deficits and cortical asymmetry in four patients with chronic tinnitus using objective and subjective measures and employing an optimization technique refined in our laboratory. Study Design. Randomized, placebo-controlled (sham stimulation) crossover study. Methods: Patients received 5 consecutive days of active, low-frequency rTMS or sham treatment (using a 45-degree coil-tilt method) before crossing over. Subjective tinnitus was assessed at baseline, after each treatment, and 4 weeks later. Positron emission tomography/computed tomography (PET/CT) scans were obtained at baseline and immediately after active treatment to examine change in cortical asymmetry. Attentional vigilance was assessed at baseline and after each treatment using a simple reaction time test. Results. All patients had a response to active (but not sham) rTMS, as indicated by their best tinnitus ratings; however, tinnitus returned in all patients by 4 weeks after active treatment. All patients had reduced cortical activity visualized on PET immediately after active rTMS. Mean reaction time improved (P < .05) after active but not sham rTMS. Conclusions. rTMS is a promising treatment modality that can transiently diminish tinnitus in some individuals, but further trials are needed to determine the optimal techniques required to achieve a lasting response. It is unclear whether the improved reaction times were caused by tinnitus reduction or a general effect of rTMS. PET/CT scans immediately after treatment suggest that improvement may be related to reduction of cortical asymmetry associated with tinnitus. C1 Univ Arkansas Med Sci, Dept Otolaryngol Head & Neck Surg, Little Rock, AR 72205 USA. Univ Arkansas Med Sci, Dept Neurobiol & Dev Sci, Little Rock, AR 72205 USA. Univ Arkansas Med Sci, Dept Radiol, Div Nucl Med, Little Rock, AR 72205 USA. Univ Arkansas Med Sci & Mental Hlth Serv, CAVHS, Little Rock, AR USA. Univ Florida, Dept Neurol, Gainesville, FL USA. RP Dornhoffer, JL (reprint author), Univ Arkansas Med Sci, Dept Otolaryngol Head & Neck Surg, 4301 W Markham Slot 543, Little Rock, AR 72205 USA. EM dornhofferjohnl@uams.edu CR Arnold W, 1996, ORL J OTO-RHINO-LARY, V58, P195 Bear MF, 1999, P NATL ACAD SCI USA, V96, P9457, DOI 10.1073/pnas.96.17.9457 Chen R, 1997, NEUROLOGY, V48, P1398 De Ridder D, 2005, OTOL NEUROTOL, V26, P616, DOI 10.1097/01.mao.0000178146.91139.3c Dornhoffer John, 2006, Int Tinnitus J, V12, P9 Folmer RL, 2001, OTOLARYNG HEAD NECK, V124, P394, DOI 10.1067/mhn.2001.114673 JACKSON P, 1985, J LARYNGOL OTOL, V99, P663, DOI 10.1017/S0022215100097449 Kleinjung T, 2005, OTOLARYNG HEAD NECK, V132, P566, DOI 10.1016/j.otohns.2004.09.134 Langguth B, 2003, NEUROREPORT, V14, P977, DOI 10.1097/01.wnr.0000068897.39523.41 Melcher JR, 2000, J NEUROPHYSIOL, V83, P1058 Plewnia C, 2003, ANN NEUROL, V53, P263, DOI 10.1002/ana.10468 PLEWNIA C, 2006, J NEUROL NEUROS 0804 Sturm W, 2004, NEUROPSYCHOLOGIA, V42, P563, DOI 10.1016/j.neuropsychologia.2003.11.004 Tai YC, 1997, IEEE T NUCL SCI, V44, P1606 Wang HT, 2001, CHINESE MED J-PEKING, V114, P848 NR 15 TC 60 Z9 65 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0023-852X J9 LARYNGOSCOPE JI Laryngoscope PD MAR PY 2007 VL 117 IS 3 BP 529 EP 534 DI 10.1097/MLG.0b013e31802f4154 PG 6 WC Medicine, Research & Experimental; Otorhinolaryngology SC Research & Experimental Medicine; Otorhinolaryngology GA 141AI UT WOS:000244548000025 PM 17334317 ER PT J AU MacDonald, JT AF MacDonald, John T. TI Objective tinnitus due to essential palatal tremor in a 5-year-old SO PEDIATRIC NEUROLOGY LA English DT Article ID MYOCLONUS AB A healthy 5-year-old male reported a clicking sound in both ears. Neurologic examination was normal except for an audible clicking noise that could be heard when within 10 cm of either ear and bilateral rapid rhythmic movements of the soft palate. All tests were normal including magnetic resonance imaging brain scan. One year after onset, his objective tinnitus and palatal tremor were no longer present. (c) 2007 by Elsevier Inc. All rights reserved. C1 Univ Minnesota, Dept Pediat, Div Pediat Clin Neurosci, Minneapolis, MN 55455 USA. RP MacDonald, JT (reprint author), Univ Minnesota, Dept Pediat, Div Pediat Clin Neurosci, Mayo Mail Code 486,420 Delaware St SE, Minneapolis, MN 55455 USA. EM JTMNEURO@EARTHLINK.NET CR CHIEN HF, 2006, PARKINSONISM RELAT D Coles RRA, 1975, BRIT J AUDIOL, V9, P1, DOI 10.3109/03005367509079101 FOX GN, 1991, WESTERN J MED, V154, P98 GOTZE A Jr, 1957, Z Laryngol Rhinol Otol, V36, P394 Jero J, 2000, Acta Otolaryngol Suppl, V543, P61 Kutukcu Y, 2003, J NEUROL, V250, P885, DOI 10.1007/s00415-003-1123-z LAPRESLE J, 1970, ARCH NEUROL-CHICAGO, V22, P135 LITMAN RS, 1982, LARYNGOSCOPE, V92, P1187 Schleuning A, 1993, HEAD NECK SURG OTOLA, P2199 SIEGEL MA, 1987, J AM DENT ASSOC, V114, P333 TANAKA M, 1984, NEUROLOGY, V34, P406 Williams DR, 2004, MOVEMENT DISORD, V19, P333, DOI 10.1002/mds.10632 Zadikoff C, 2006, BRAIN, V129, P832, DOI 10.1093/brain/awh684 NR 13 TC 5 Z9 5 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0887-8994 J9 PEDIATR NEUROL JI Pediatr. Neurol. PD MAR PY 2007 VL 36 IS 3 BP 175 EP 176 DI 10.1016/j.pediatrneurol.2006.10.009 PG 2 WC Clinical Neurology; Pediatrics SC Neurosciences & Neurology; Pediatrics GA 150DW UT WOS:000245196800007 PM 17352951 ER PT J AU Behr, R Muller, J Shehata-Dieler, W Schlake, HP Helms, J Roosen, K Klug, N Holper, B Lorens, A AF Behr, Robert Mueller, Joachim Shehata-Dieler, Wafaa Schlake, Hans-Peter Helms, Jan Roosen, Klaus Klug, Norfrid Hoelper, Bernd Lorens, Artur TI The high rate CIS auditory brainstem implant for restoration of hearing in NF-2 patients SO SKULL BASE-AN INTERDISCIPLINARY APPROACH LA English DT Article DE cochlear nucleus stimulation; auditory brainstem implant; neurofibromatosis; acoustic neurinoma surgery; high rate CIS stimulation ID COCHLEAR IMPLANT; CODING STRATEGY; NUCLEUS; PERFORMANCE AB Aim: Hearing preservation is one of the major goals of acoustic neuroma surgery. In NF-2 patients, bilateral hearing loss is frequently caused by the disease or results from its treatment. Several implant devices for electrical stimulation of the cochlear nucleus have been developed to restore serviceable hearing in these patients. We report our experience and results using a high rate continuous interleaved sampling (CIS) auditory brainstem implant (ABI). Methods: Between June 1997 and May 2004, 24 NF-2 patients were managed by our group. In 20 patients an ABI was implanted successfully. The cochlear nucleus was located using anatomical landmarks and E-ABR recordings after resection of the neuroma via a retrosigmoid approach in the semi-sitting position. The 12-channel stimulating electrode array was inserted and fixed in the lateral recess. There were no surgical complications related to implantation apart from pseudomeningoceles that were managed by lumbar drainage. Results: In one patient the electrode array became dislocated and this necessitated revision surgery which was successful. One patient failed to gain benefit from the implant. Overall, 70% of electrodes were found to be serviceable for auditory stimulation, 5.3% of electrodes were primarily nonauditory, and in 7.8% side effects during stimulation were observed. Lip reading was improved by more than 100% as a result of the additional auditory input. For many patients, comprehension of open speech was restored to a useful level. Almost an patients were able to perceive environmental sounds and tinnitus was masked. Conclusions: Restoration of hearing using ABIs in NF-2 patients is a safe and promising procedure for those who would otherwise be totally deaf The high rate CIS speech processing strategy has proven to be very useful and effective in direct cochlear nucleus stimulation. C1 Univ Marburg, Acad Hosp, Dept Neurosurg, Klinikum Fulda gAG, D-36043 Fulda, Germany. Univ Wurzburg, Dept Neurosurg, Wurzburg, Germany. Univ Wurzburg, Dept Otorhinolaryngol, Wurzburg, Germany. Univ Cologne, Dept Gen Neurosurg, Cologne, Germany. Inst Physiol & Pathol Hearing, Warsaw, Poland. RP Behr, R (reprint author), Univ Marburg, Acad Hosp, Dept Neurosurg, Klinikum Fulda gAG, Pacelliallee 4, D-36043 Fulda, Germany. 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Appr. PD MAR PY 2007 VL 17 IS 2 BP 91 EP 107 DI 10.1055/s-2006-950390 PG 17 WC Clinical Neurology; Otorhinolaryngology; Surgery SC Neurosciences & Neurology; Otorhinolaryngology; Surgery GA 153RW UT WOS:000245453800001 PM 17768439 ER PT J AU Kaulen, H AF Kaulen, Hildegard TI Tinnitus: difficult to treat problem? SO DEUTSCHE MEDIZINISCHE WOCHENSCHRIFT LA German DT Article NR 0 TC 0 Z9 0 PU GEORG THIEME VERLAG KG PI STUTTGART PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY SN 0012-0472 J9 DEUT MED WOCHENSCHR JI Dtsch. Med. Wochenschr. PD FEB 23 PY 2007 VL 132 IS 8 BP 361 EP 362 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA 141QI UT WOS:000244593400003 ER PT J AU Mazurek, B AF Mazurek, Birgit TI Multimodal therapy approach with tinnitus retraining therapy SO DEUTSCHE MEDIZINISCHE WOCHENSCHRIFT LA German DT News Item NR 0 TC 0 Z9 0 PU GEORG THIEME VERLAG KG PI STUTTGART PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY SN 0012-0472 EI 1439-4413 J9 DEUT MED WOCHENSCHR JI Dtsch. Med. Wochenschr. PD FEB 23 PY 2007 VL 132 IS 8 BP 362 EP 362 PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA 141QI UT WOS:000244593400004 ER PT J AU Weisz, N Muller, S Schlee, W Dohrmann, K Hartmann, T Elbert, T AF Weisz, Nathan Mueller, Simona Schlee, Winfried Dohrmann, Katalin Hartmann, Thomas Elbert, Thomas TI The neural code of auditory phantom perception SO JOURNAL OF NEUROSCIENCE LA English DT Article DE tinnitus; phantom perception; gamma band activity; slow-wave activity; magnetoencephalography; spontaneous activity ID HEARING-LOSS; TINNITUS; FREQUENCY; MAGNETOENCEPHALOGRAPHY; PLASTICITY; DYNAMICS; SYSTEMS AB Tinnitus is defined by an auditory perception in the absence of an external source of sound. This condition provides the distinctive possibility of extracting neural coding of perceptual representation. Previously, we had established that tinnitus is characterized by enhanced magnetic slow-wave activity (similar to 4 Hz) in perisylvian or putatively auditory regions. Because of works linking high-frequency oscillations to conscious sensory perception and positive symptoms in a variety of disorders, we examined gamma band activity during brief periods of marked enhancement of slow-wave activity. These periods were extracted from 5 min of resting spontaneous magne-toencephalography activity in 26 tinnitus and 21 control subjects. Results revealed the following, particularly within a frequency range of 50 - 60 Hz: (1) Both groups showed significant increases in gamma band activity after onset of slow waves. (2) Gamma is more prominent in tinnitus subjects than in controls. (3) Activity at similar to 55 Hz determines the laterality of the tinnitus perception. Based on present and previous results, we have concluded that cochlear damage, or similar types of deafferentation from peripheral input, triggers reorganization in the central auditory system. This produces permanent alterations in the ongoing oscillatory dynamics at the higher layers of the auditory hierarchical stream. The change results in enhanced slow-wave activity reflecting altered corticothalamic and corticolimbic interplay. Such enhancement facilitates and sustains gamma activity as a neural code of phantom perception, in this case auditory. C1 INSERM, U280, F-69500 Bron, France. Univ Konstanz, Dept Psychol, D-78464 Constance, Germany. RP Weisz, N (reprint author), Ctr Hosp Vinatier, INSERM, U280, Batiment 452,95 Blvd Pinel, F-69500 Bron, France. EM weisz@lyon.inserm.fr RI Elbert, Thomas/C-8556-2009; Schlee, Winfried/C-8983-2011 OI Schlee, Winfried/0000-0001-7942-1788 CR BERG P, 1994, ELECTROEN CLIN NEURO, V90, P229, DOI 10.1016/0013-4694(94)90094-9 Bledowski C, 2006, J NEUROSCI, V26, P821, DOI 10.1523/JNEUROSCI.3542-05.2006 CALFORD MB, 1993, NEUROSCIENCE, V55, P953, DOI 10.1016/0306-4522(93)90310-C Delorme A, 2004, J NEUROSCI METH, V134, P9, DOI 10.1016/j.jneumeth.2003.10.009 Eggermont JJ, 2004, TRENDS NEUROSCI, V27, P676, DOI 10.1016/j.tins.2004.08.010 Fernandez A, 2002, BIOL PSYCHIAT, V52, P764, DOI 10.1016/S0006-3223(02)01366-5 Goebel G, 1998, TINNITUS FRAGEBOGEN Irvine DRF, 2001, AUDIOL NEURO-OTOL, V6, P192, DOI 10.1159/000046831 Jeanmonod D, 1996, BRAIN, V119, P363, DOI 10.1093/brain/119.2.363 Konig O, 2006, HEARING RES, V221, P59, DOI 10.1016/j.heares.2006.07.007 Llinas R, 2005, TRENDS NEUROSCI, V28, P325, DOI 10.1016/j.tins.2005.04.006 Llinas R, 1998, PHILOS T ROY SOC B, V353, P1841, DOI 10.1098/rstb.1998.0336 Llinas RR, 1999, P NATL ACAD SCI USA, V96, P15222, DOI 10.1073/pnas.96.26.15222 Meinzer Marcus, 2004, BMC Biol, V2, P20, DOI 10.1186/1741-7007-2-20 MOORE BC, 2000, BRIT J AUDIOL, V4, P205 Norena A, 2002, AUDIOL NEURO-OTOL, V7, P358, DOI 10.1159/000066156 Norena AJ, 2003, HEARING RES, V183, P137, DOI 10.1016/S0378-5955(03)00225-9 Rajan R, 1998, AUDIOL NEURO-OTOL, V3, P123, DOI 10.1159/000013786 Sarnthein J, 2006, BRAIN, V129, P55, DOI 10.1093/brain/awh631 Scherg M, 2002, J CLIN NEUROPHYSIOL, V19, P91, DOI 10.1097/00004691-200203000-00001 Singer W, 1999, NEURON, V24, P49, DOI 10.1016/S0896-6273(00)80821-1 Steriade M, 2006, NEUROSCIENCE, V137, P1087, DOI 10.1016/j.neuroscience.2005.10.029 Weisz N, 2006, HEARING RES, V222, P108, DOI 10.1016/j.heares.2006.09.003 Weisz N., 2005, PLOS MED, V2, DOI DOI 10.1371/J0URNAL.PMED.0020153 NR 24 TC 147 Z9 151 PU SOC NEUROSCIENCE PI WASHINGTON PA 11 DUPONT CIRCLE, NW, STE 500, WASHINGTON, DC 20036 USA SN 0270-6474 J9 J NEUROSCI JI J. Neurosci. PD FEB 7 PY 2007 VL 27 IS 6 BP 1479 EP 1484 DI 10.1523/JNEUROSCI.3711-06.2007 PG 6 WC Neurosciences SC Neurosciences & Neurology GA 134FX UT WOS:000244070000029 PM 17287523 ER PT J AU Ngai, S Tang, YM Du, L Stuckey, S AF Ngai, S. Tang, Y. M. Du, L. Stuckey, S. TI Hyperintensity of the precentral gyral subcortical white matter and hypointensity of the precentral gyrus on fluid-attenuated inversion recovery: Variation with age and implications for the diagnosis of amyotrophic lateral sclerosis SO AMERICAN JOURNAL OF NEURORADIOLOGY LA English DT Article ID UPPER MOTOR-NEURON; CORTICOSPINAL TRACT; CEREBRAL-CORTEX; FLAIR IMAGES; MRI; INTENSITY; DISEASES; ALS AB BACKGROUND AND PURPOSE: Hyperintensity of the subcortical white matter (SWM) of the precentral gyrus and hypointensity of the precentral gyrus gray matter (PGGM) on fluid-attenuated inversion recovery (FLAIR) are described as potentially useful diagnostic findings in annyotrophic lateral sclerosis (ALS). A detailed study of the prevalence of these findings in various age groups has not been described. METHODS: One hundred twenty-two patients underwent axial FLAIR brain examinations as part of either hearing loss or tinnitus evaluation. Examinations were randomly selected to reflect an even spread through the decades from ages 15 to 78 years and were reviewed by 2 readers, blinded to patient's age and sex, for the presence/absence of the above 2 signs. If SWM hyperintensity was present, it was graded as intense as caudate nucleus (grade 1) or insula (grade 2). RESULTS: We identified 32 cases of grade 1 and 5 cases of grade 2 SWM hyperintensity, and 28 cases of PGGM hypointensity. Both signs showed significant Spearman correlation with increasing age (r = 0.55, P < .001 for grade 1, r = 0.45, P < .001 for grade 2 SWM hyperintensity, r = 0.45, P < .001 for PGGIVI hypointensity). Analysis of variance showed there was a significant difference between the different age groups (P < .001) for both signs. Grading of the SWM and PGGIVI signals were highly reproducible with very good interobserver agreement (r = 0.88, P < .001, and r = 0.97, P < .001, respectively). CONCLUSION: This study suggests a statistically significant relationship between increasing age and the frequency of precentral gyrus SWM hyperintensity and PGGM hypointensity on FLAIR, and reinforces previous reports that these signs can be seen in patients who do not have ALS. C1 Princess Alexandra Hosp, Dept Radiol, Brisbane, Qld 4102, Australia. RP Ngai, S (reprint author), Princess Alexandra Hosp, Dept Radiol, Ipswich Rd, Brisbane, Qld 4102, Australia. EM sngai01@hotmail.com CR Bowen BC, 2000, AM J NEURORADIOL, V21, P647 Chan S, 2003, NEUROIMAG CLIN N AM, V13, P307, DOI 10.1016/S1052-5149(03)00018-2 da Rocha AJ, 2004, AM J NEURORADIOL, V25, P1509 Graham JM, 2004, NEUROLOGY, V63, P2111 HAJNAL JV, 1992, J COMPUT ASSIST TOMO, V16, P506, DOI 10.1097/00004728-199207000-00002 HAVERKAMP LJ, 1995, BRAIN, V118, P707, DOI 10.1093/brain/118.3.707 Hecht MJ, 2002, J NEUROL SCI, V199, P59, DOI 10.1016/S0022-510X(02)00104-1 Hecht MJ, 2001, J NEUROL SCI, V186, P37, DOI 10.1016/S0022-510X(01)00503-2 Hirai T, 1996, RADIOLOGY, V199, P799 Imon Y, 1998, NEURORADIOLOGY, V40, P76 Imon Y, 1995, J NEUROL SCI, V134, P27, DOI 10.1016/0022-510X(95)00205-G Sach M, 2004, BRAIN, V127, P340, DOI 10.1093/brain/awh041 Waragai M, 1997, J NEUROL NEUROSUR PS, V62, P88, DOI 10.1136/jnnp.62.1.88 Worms PA, 2001, J NEUROL SCI, V191, P3, DOI 10.1016/S0022-510X(01)00630-X Zhang LJ, 2003, J MAGN RESON IMAGING, V17, P521, DOI 10.1002/jmri.10293 NR 15 TC 19 Z9 22 PU AMER SOC NEURORADIOLOGY PI OAK BROOK PA 2210 MIDWEST RD, OAK BROOK, IL 60521 USA SN 0195-6108 J9 AM J NEURORADIOL JI Am. J. Neuroradiol. PD FEB PY 2007 VL 28 IS 2 BP 250 EP 254 PG 5 WC Clinical Neurology; Neuroimaging; Radiology, Nuclear Medicine & Medical Imaging SC Neurosciences & Neurology; Radiology, Nuclear Medicine & Medical Imaging GA 136ZS UT WOS:000244263200015 PM 17296988 ER PT J AU Savastano, M Aita, M Barlani, F AF Savastano, Marina Aita, Maria Barlani, Federico TI Psychological, neural, endocrine, and immune study of stress in tinnitus patients: Any correlation between psychometric and biochemical measures? SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE biochemistry; psychometry; stress; tinnitus ID PSYCHONEUROIMMUNOLOGY; DISTRESS; SUFFERERS; SEVERITY; HEALTH AB Objectives: The present study was carried out in tinnitus patients in order to study the psychological distress and the biochemical measures of this stressful condition. Psychological features were compared to immune and neuroendocrine parameters in order to verify in these subjects the possible presence of psychological and somatic responses to stress. Methods: We studied 85 tinnitus patients who underwent hematochemical immune tests: lymphocyte subpopulations (CD3; CD4; CD3+CD4; CD8; CD19; CD16NK; CD3+CD16+CD56; and CD4/CD8), cortisol, adrenocorticotropic hormone, beta-endorphin, prolactin, and urinary catecholamine. Results: Clinically, significant scores were obtained for hysteria, depression, paranoia, hypochondrias, and social introversion; and high scores were obtained for anxiety, depression, care for health, difficulty of treatment, low self-esteem, family and work difficulties, and social discomfort. There was a low to medium level of self-perception of stress. The less a subject felt stressed, the higher was his or her satisfaction level in the areas of psychological and physical functioning. The scores on the tests and the biochemical measures did not show a significant correlation, but there was a tendency to correlation for the lymphocytes CD19 and CD16NK and for adrenocorticotropic hormone. Conclusions: The comparison between the psychometric and biochemical variables did not reveal any significant correlation among stress perception, daily satisfaction, and the biochemical parameters of stress. C1 Univ Padua, Dept Otolaryngol Head & Neck Surg, I-35100 Padua, Italy. Univ Padua, Dept Psychiat, I-35100 Padua, Italy. RP Savastano, M (reprint author), Dept Med Surg Specialties, Sect Otorhinolaryngol, Via Giustiniana 2, I-35128 Padua, Italy. CR Ader R, 2000, EUR J PHARMACOL, V405, P167, DOI 10.1016/S0014-2999(00)00550-1 Andersson G, 1999, CLIN OTOLARYNGOL, V24, P404, DOI 10.1046/j.1365-2273.1999.00278.x Budd RJ, 1995, J PSYCHOSOM RES, V39, P1015, DOI 10.1016/0022-3999(95)00512-9 D'Amelio R, 2004, HNO, V52, P599, DOI 10.1007/s00106-003-0944-5 DeKeyser Freda, 2003, AACN Clin Issues, V14, P25, DOI 10.1097/00044067-200302000-00004 ERLANDSSON SI, 1992, AUDIOLOGY, V31, P168 ERLANDSSON S I, 1991, British Journal of Audiology, V25, P15, DOI 10.3109/03005369109077860 Fox S, 1999, J Neurosci Nurs, V31, P87 Harter M, 2004, HNO, V52, P125, DOI 10.1007/s00160-003-0889-8 Hiller W, 2004, INT J AUDIOL, V43, P600 Holgers Kajsa-Mia, 2003, Lakartidningen, V100, P3744 Kemeny M E, 1999, Semin Gastrointest Dis, V10, P20 KEMP S, 1992, BRIT J AUDIOL, V26, P381, DOI 10.3109/03005369209076662 Kiecolt-Glaser JK, 2002, PSYCHOSOM MED, V64, P15 Lutgendorf SK, 2003, BRAIN BEHAV IMMUN, V17, P225, DOI 10.1016/S0889-1591(03)00033-3 Lutz Waldemar, 2001, Medycyna Pracy, V52, P203 Mausch K, 2000, Psychiatr Pol, V34, P381 Prolo P, 2002, ANN NY ACAD SCI, V966, P400 Rizzardo R, 1998, J OTOLARYNGOL, V27, P21 Sachanska T, 1999, Int Tinnitus J, V5, P24 Savastano M, 1999, Int Tinnitus J, V5, P121 van Veen ED, 1998, J LARYNGOL OTOL, V112, P258 Vedhara K, 1999, NEUROSCI BIOBEHAV R, V23, P699, DOI 10.1016/S0149-7634(99)00012-3 Weber C, 2002, J PSYCHOSOM RES, V52, P29, DOI 10.1016/S0022-3999(01)00281-1 Whitesman S, 2004, SAMJ S AFR MED J, V94, P259 Yang EV, 2002, INT IMMUNOPHARMACOL, V2, P315, DOI 10.1016/S1567-5769(01)00182-5 NR 26 TC 6 Z9 7 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD FEB PY 2007 VL 116 IS 2 BP 100 EP 106 PG 7 WC Otorhinolaryngology SC Otorhinolaryngology GA 139JD UT WOS:000244427200004 PM 17388232 ER PT J AU Aksoy, S Akdogan, O Gedikli, Y Belgin, E AF Aksoy, Songul Akdogan, Oezgur Gedikli, Yesim Belgin, Erol TI The extent and levels of tinnitus in children of central Ankara SO INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY LA English DT Article DE tinnitus; childhood; normal hearing ID CHILDHOOD AB Objective: The objective of this study is to determine the presence and prevalence of tinnitus among primary school and junior high school students in central Ankara. Methods: In the first stage of the study, all students were tested for the presence of tinnitus by answering a comprehensive questionnaire. The students who had previous ear operations were excluded from the rest of the study. The initial survey/tests yielded presence of tinnitus, frequency of occurrence, characteristics, associated symptoms and the age groups. Results: 15.1% of the children reported to have tinnitus. No significant difference was found between gender (female 45.5%, male 54.4%) and ears (right 25.3%, left 25.5%). The age group that suffered most from tinnitus is 14 years old (20.8%), 25 children had positive family history (16.2%), 44 children had headaches as the most common accompanying symptom (28.6%), 64 of them had tiredness as the predisposing factor (41.6%) and 52 of them have defined worsening of tinnitus during mornings (33.8%). The characteristics of tinnitus were identified as high pitch (n = 125, 81.2%), soft loudness (n = 124, 80.5%) and ringing (n = 61, 39.6%). Conclusions: The study produced much needed data to shed light onto understanding levels and characteristics of tinnitus in school children in Turkey. The data obtained was carefully analyzed and found to be comparative to international studies (C) 2006 Elsevier Ireland Ltd. All rights reserved. C1 Hacettepe Univ, Fac Med, Dept Otorhinolaryngol Head & Neck Surg, Sect Audiol & Speech Pathol, TR-06100 Ankara, Turkey. Ankara Numune Training & Res Hosp, Ear Nose & Throat Dis Clin 4, Ankara, Turkey. RP Aksoy, S (reprint author), Univ Hacettepe, Kulak Nurun Nogaz Anabilim Dali, Odyoloji & Konusma Bozukluklari Unitesi, TR-06100 Ankara, Turkey. EM songulaksoy@hotmail.com CR American National Standards Institute, 1996, S36 ANSI American Speech-Language-Hearing Association, 1997, GUID AUD SCREEN Baguley DM, 1999, INT J PEDIATR OTORHI, V49, P99, DOI 10.1016/S0165-5876(99)00111-1 BAUER CA, 2004, OTOLARYNGOL HEAD NEC, V12, P413 BENDAVID J, 1995, INT TINNITUS J, V1, P155 DRUKIER GS, 1989, AM ANN DEAF, V134, P260 Fritsch MH, 2001, OTOL NEUROTOL, V22, P644, DOI 10.1097/00129492-200109000-00015 Graham J M, 1981, Ciba Found Symp, V85, P172 GRAHAM JM, 1995, MECHANISMS TINNITUS, P51 Jastreboff P J, 2000, J Am Acad Audiol, V11, P162 LEONARD G, 1983, PEDIAT OTOLARYNGOLOG, P271 Lockwood AH, 1998, NEUROLOGY, V50, P114 MARTIN K, 1994, BRIT J AUDIOL, V28, P111, DOI 10.3109/03005369409077921 MCFADDEN D, 1982, TINNITUS FACT THEORI MILLER JF, 1984, HELIA, V7, P17 MILLS RP, 1984, INT J PEDIATR OTORHI, V7, P21, DOI 10.1016/S0165-5876(84)80050-6 MILLS RP, 1986, CLIN OTOLARYNGOL, V11, P431, DOI 10.1111/j.1365-2273.1986.tb00147.x MORTIMER MJ, 1992, DEV MED CHILD NEUROL, V34, P1095 NODAR R, 1972, AUDITORY RES, V12, P133 POTOSHIN L, 1997, INT TINNITUS J, V3, P101 Savastano M, 2002, INT J PEDIATR OTORHI, V64, P23, DOI 10.1016/S0165-5876(02)00031-9 STOUFFER JL, 1992, TINNITUS 91, P255 VIANI LG, 1989, J LARYNGOL OTOL, V103, P1142, DOI 10.1017/S0022215100111223 NR 23 TC 12 Z9 13 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0165-5876 J9 INT J PEDIATR OTORHI JI Int. J. Pediatr. Otorhinolaryngol. PD FEB PY 2007 VL 71 IS 2 BP 263 EP 268 DI 10.1016/j.ijporl.2006.10.008 PG 6 WC Otorhinolaryngology; Pediatrics SC Otorhinolaryngology; Pediatrics GA 133MZ UT WOS:000244018300010 PM 17126917 ER PT J AU Mahendran, S Sunkaraneni, VS Baguley, DM Axon, PR AF Mahendran, S. Sunkaraneni, V. S. Baguley, D. M. Axon, P. R. TI Superior semicircular canal dehiscence with a large tegmental defect SO JOURNAL OF LARYNGOLOGY AND OTOLOGY LA English DT Article DE semicircular canals; middle cranial fossa; otologic surgical procedures ID PRESSURE-INDUCED VERTIGO; PULSATILE TINNITUS; BONE DEHISCENCE; BRAIN AB We report on the presentation and clinical manifestations of superior semicircular canal dehiscence in association with a large defect of the tegmen tympani in a 41-year-old woman with no previous history of trauma. Based on this case we recommend that clinicians consider the possibility of superior semicircular canal dehiscence in patients presenting with symptoms associated with tegmen defects. C1 Addenbrookes Hosp, Dept ENT Skull Base Surg, Cambridge CB2 2XX, England. RP Axon, PR (reprint author), Addenbrookes Hosp, Dept ENT Skull Base Surg, Hills Rd, Cambridge CB2 2XX, England. EM patrick.axon@addenbrookes.nhs.uk CR Belden CJ, 2003, RADIOLOGY, V226, P337, DOI 10.1148/radiol.2262010897 Brantberg K, 1999, ACTA OTO-LARYNGOL, V119, P633 Brantberg K, 2001, ACTA OTO-LARYNGOL, V121, P68 Carey JP, 2000, ARCH OTOLARYNGOL, V126, P137 GOLDINGWOOD DG, 1991, J LARYNGOL OTOL, V105, P477, DOI 10.1017/S0022215100116354 Halmagyi GM, 2003, J LARYNGOL OTOL, V117, P553 Halmagyi GM, 2003, NEUROLOGY, V60, P1172 Hirvonen TP, 2003, ACTA OTO-LARYNGOL, V123, P477, DOI 10.1080/0036554021000028099 Kale SU, 2000, J LARYNGOL OTOL, V114, P861 Kuhweide R, 1999, ANN OTO RHINOL LARYN, V108, P653 Mikulec AA, 2004, OTOL NEUROTOL, V25, P121, DOI 10.1097/00129492-200403000-00007 Minor LB, 1998, ARCH OTOLARYNGOL, V124, P249 Moffat DA, 1998, AM J OTOL, V19, P819 RAMSDEN RT, 1985, J LARYNGOL OTOL, V99, P643, DOI 10.1017/S0022215100097413 Xenellis J, 2005, OTOL NEUROTOL, V26, P1149, DOI 10.1097/01.mao.0000194888.36400.d5 NR 15 TC 5 Z9 5 PU CAMBRIDGE UNIV PRESS PI CAMBRIDGE PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND SN 0022-2151 J9 J LARYNGOL OTOL JI J. Laryngol. Otol. PD FEB PY 2007 VL 121 IS 2 BP 189 EP 191 DI 10.1017/S0022215106004178 PG 3 WC Otorhinolaryngology SC Otorhinolaryngology GA 224YN UT WOS:000250484400022 PM 17059625 ER PT J AU Dornhoffer, JL Mennemeier, M AF Dornhoffer, J. L. Mennemeier, M. TI Transcranial magnetic stimulation and tinnitus: implications for theory and practice SO JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY LA English DT Editorial Material ID SUPPRESSION AB Tinnitus remains an enigma, with no consensus on the pathophysiology or treatment of this condition. Transcranial magnetic stimulation has recently emerged as a possible treatment modality that has shown some promise. The paper by Plewnia et al,(1) (see p 152) reported on the efficacy of delivering 10 sessions of low-frequency repetitive transcranial magnetic stimulation (rTMS) over the temporoparietal association cortex to treat chronic tinnitus. Although rTMS is known to effect change in tinnitus perception, 2-4 it is unclear how this change occurs and what method of application is most effective. Plewnia et al(1) provide new information with implications for possible future clinical use. In contrast with previous studies, 3 Plewnia et al show only a temporary effect of rTMS on tinnitus, at least with currently used treatment schedules. The study also highlights the fact that blood flow asymmetries associated with tinnitus, and commonly used to target rTMS, can be quite variable among patients. In contrast with previous studies, which have focused on the primary auditory cortex, this study suggests that rTMS may attenuate tinnitus perception by influencing neural systems related to attention and emotion. To individually adjust selection of the target area for rTMS, Plewnia et al used [O-15] H2O positron emmision tomography before and after a lidocaine-induced reduction in tinnitus loudness to obtain each patient's maximum of tinnitus-related cortical activity, as measured by regional cerebral blood flow (rCBF). A reduction in tinnitus after active rTMS correlated with change in rCBF in the anterior cingulate cortex immediately after the lidocaine injection. The temporoparietal cortex and the anterior cingulate cortex are known components of neural systems that mediate attention. 5 Interestingly, deficits in attention in people with tinnitus have been documented in the laboratory. 6 If rTMS is to be used clinically for the treatment of tinnitus, future studies must consider the following questions. Firstly, what schedule of rTMS can promote longterm change in tinnitus perception? Consecutive, week-long treatment schedules can ameliorate tinnitus in the short run, but booster sessions may be necessary as symptoms return to effect a long-term change. Secondly, do the asymmetries in rCBF observed in association with tinnitus change as tinnitus improves? Follow-up neuroimaging is necessary to learn whether these asymmetries are relevant and to validate models of tinnitus perception that concern cortical contributions. C1 Univ Arkansas Med Sci, Div Otol Neurotol, Dept Otolaryngol & Head & Neck Surg, Little Rock, AR 72205 USA. Univ Arkansas Med Sci, Div Otol Neurotol, Dept Neurobiol & Dev Sci, Little Rock, AR 72205 USA. RP Dornhoffer, JL (reprint author), Univ Arkansas Med Sci, Div Otol Neurotol, Dept Otolaryngol & Head & Neck Surg, Little Rock, AR 72205 USA. EM dornhofferjohnl@uams.edu CR De Ridder D, 2005, OTOL NEUROTOL, V26, P616, DOI 10.1097/01.mao.0000178146.91139.3c Dornhoffer John, 2006, Int Tinnitus J, V12, P9 Kleinjung T, 2005, OTOLARYNG HEAD NECK, V132, P566, DOI 10.1016/j.otohns.2004.09.134 Plewnia C, 2003, ANN NEUROL, V53, P263, DOI 10.1002/ana.10468 Plewnia C, 2007, J NEUROL NEUROSUR PS, V78, P152, DOI 10.1136/jnnp.2006.095612 Sturm W, 1999, NEUROPSYCHOLOGIA, V37, P797, DOI 10.1016/S0028-3932(98)00141-9 NR 6 TC 5 Z9 5 PU B M J PUBLISHING GROUP PI LONDON PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND SN 0022-3050 J9 J NEUROL NEUROSUR PS JI J. Neurol. Neurosurg. Psychiatry PD FEB PY 2007 VL 78 IS 2 BP 113 EP 113 DI 10.1136/jnnp.2006.0103135 PG 1 WC Clinical Neurology; Psychiatry; Surgery SC Neurosciences & Neurology; Psychiatry; Surgery GA 126NY UT WOS:000243520800003 PM 17229742 ER PT J AU Plewnia, C Reimold, M Najib, A Reischl, G Plontke, SK Gerloff, C AF Plewnia, C. Reimold, M. Najib, A. Reischl, G. Plontke, S. K. Gerloff, C. TI Moderate therapeutic efficacy of positron emission tomography-navigated repetitive transcranial magnetic stimulation for chronic tinnitus: a randomised, controlled pilot study SO JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY LA English DT Article ID MOTOR CORTEX EXCITABILITY; FUNCTIONAL-ANATOMY; SUPPRESSION; RTMS; DEPRESSION; ANNOYANCE AB Background: Tinnitus has been shown to respond to modulations of cortical activity by high-frequency and low-frequency repetitive transcranial magnetic stimulation (rTMS). Objective: To determine the tinnitus-attenuating effects of a 2-week daily regimen of rTMS, navigated to the maximum of tinnitus-related increase in regional cerebral blood flow. Methods: Six patients with chronic tinnitus were enrolled in this sham-controlled crossover study and treated with 262 weeks of suprathreshold 1 Hz rTMS (30 min) applied to the region with maximal tinnitus-related increase in regional cerebral blood flow delineated by functional imaging with [(15)O]H(2)O positron emission tomography and a control area. Tinnitus-related distress was assessed before and after each treatment and 2 weeks after the end of the 4-week course of stimulation using a validated tinnitus questionnaire. Additional self-assessment scores of tinnitus change, loudness and annoyance were obtained. Results: In five of six patients, rTMS induced greater reduction of the tinnitus questionnaire score than sham stimulation. In two patients, all parameters measured (tinnitus change score, tinnitus loudness, tinnitus annoyance) showed unequivocal improvement. At the group level, the degree of response in the tinnitus questionnaire score was correlated with tinnitus- associated activation of the anterior cingulate cortex. Two weeks after the final stimulation, tinnitus had returned to baseline in all patients but one. Conclusion: Tinnitus can be attenuated by low-frequency rTMS navigated to each person's maximum tinnitus-related cortical hyperactivity. The effects are only moderate; interindividual responsiveness varies and the attenuation seems to wear off within 2 weeks after the last stimulation session. Notably, tinnitus- related anterior cingulate cortex activation seems to predict the response to rTMS treatment. C1 Univ Tubingen, Brain Stimulat Lab, Dept Psychiat, D-72076 Tubingen, Germany. Univ Tubingen, PET Ctr, Dept Nucl Med, D-72076 Tubingen, Germany. Univ Tubingen, Cort Physiol Res Grp, Dept Gen Neurol, Hertie Inst Clin Brain Res, D-72076 Tubingen, Germany. Univ Tubingen, Dept Nucl Med, Radiopharmacol Sect, D-72076 Tubingen, Germany. Univ Tubingen, Tuebingen Hearing Res Ctr, Dept Otorhinolaryngol Head & Neck Surg, D-72076 Tubingen, Germany. Univ Hamburg, Med Ctr Eppendorf, Ctr Clin Neurosci, Dept Neurol, Hamburg, Germany. RP Plewnia, C (reprint author), Univ Tubingen, Brain Stimulat Lab, Dept Psychiat, Osianderstr 24, D-72076 Tubingen, Germany. 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Neurol. Neurosurg. Psychiatry PD FEB PY 2007 VL 78 IS 2 BP 152 EP 156 DI 10.1136/jnnp.2006.095612 PG 5 WC Clinical Neurology; Psychiatry; Surgery SC Neurosciences & Neurology; Psychiatry; Surgery GA 126NY UT WOS:000243520800011 PM 16891384 ER PT J AU Dundar, K Gumus, T Ay, H Yetiser, S Ertugrul, E AF Dundar, Kadir Gumus, Tuna Ay, Hakan Yetiser, Sertac Ertugrul, Eylem TI Effectiveness of hyperbaric oxygen on sudden sensorineural hearing loss: Prospective clinical research SO JOURNAL OF OTOLARYNGOLOGY LA English DT Article DE hyperbaric oxygen; sudden sensorineural hearing loss ID INNER-EAR; THERAPY; TINNITUS; DEAFNESS; PLACEBO AB The role of hyperbaric oxygen (HBO) treatment in sudden sensorineural hearing loss (SSNHL) is still controversial. In this study, 80 patients were treated for SSNHL. Fifty-five patients who received HBO and medical treatment and 25 patients who received medical treatment only were studied. There was a statistically significant difference between the HBO and medical treatment group and the medical treatment group for hearing gain and the degree of hearing loss after treatment (p <.05). In the HBO and medical treatment group, patients with tinnitus showed the highest hearing improvement. The patients who had tinnitus had a statistically significant difference for hearing gain in the HBO and medical treatment group (p <.05) but not in the medical treatment group (p >.05). In the HBO and medical treatment group, average hearing gain on each audiometric frequency was better than in the medical treatment group (p <.05). C1 Gulhane Mil Med Acad, Undersea & Hyperbar Med Dept, TR-06018 Ankara, Turkey. Gulhane Mil Med Acad, Dept Ear Nose & Throat, TR-06018 Ankara, Turkey. RP Gumus, T (reprint author), Gulhane Mil Med Acad, Undersea & Hyperbar Med Dept, TR-06018 Ankara, Turkey. EM tunagumus@yahoo.com CR Aslan I, 2002, OTOLARYNG HEAD NECK, V126, P121, DOI 10.1067/mhn.2002.121915 BOHMER D, 1997, INT TINNITUS J, V3, P137 Delb W, 1999, HNO, V47, P1038, DOI 10.1007/s001060050488 Escada PA, 2004, J LARYNGOL OTOL, V118, P143 FUJINO M, 1999, EUR ARCH OTO-RHINO-L, V256, P18 Fuse K, 1996, ORL J OTO-RHINO-LARY, V58, P175 GARCIABERROCAL JRG, 2000, ACTA OTO-LARYNGOL, V120, P835 Gianoli GJ, 2001, OTOLARYNG HEAD NECK, V125, P142, DOI 10.1067/mhn.2001.117162 GOTO F, 1979, ACTA OTO-LARYNGOL, V88, P335, DOI 10.3109/00016487909137177 Hsu YC, 2004, OTOLARYNG HEAD NECK, V130, P271, DOI 10.1016/S0194-5998(03)01589-4 HU ZY, 1991, AVIAT SPACE ENVIR MD, V62, P403 Kallinen J, 1999, ANN OTO RHINOL LARYN, V108, P944 Kessler R, 2004, HNO, V52, P63, DOI 10.1007/s00106-003-0972-1 Koc A, 2003, J OTOLARYNGOL, V32, P308, DOI 10.2310/7070.2003.11288 KOHUT RI, 1986, ANN OTO RHINOL LARYN, V95, P466 KRONENBERG J, 1992, LARYNGOSCOPE, V102, P65 Lamm H, 1971, HNO, V19, P363 Lamm K, 1998, ADV OTO-RHINO-LARYNG, V54, P59 Lamm K, 1998, ADV OTO-RHINO-LARYNG, V54, P86 Landreau P, 1991, Rev Laryngol Otol Rhinol (Bord), V112, P185 MANI H, 2003, OTOLARYNGOL HEAD NEC, V128, P92 MARSH RR, 1985, OTOLARYNG HEAD NECK, V93, P390 MOSKOWITZ D, 1984, LARYNGOSCOPE, V94, P664 MUZAFFER K, 2003, J OTOLARYNGOL, V32, P384 MYERS RAM, 1986, HYPERBARIC OXYGEN TH PILGRAMM M, 1985, LARYNG RHINOL OTOL V, V64, P351, DOI 10.1055/s-2007-1008158 Racic G, 2003, ORL J OTO-RHINO-LARY, V65, P317, DOI 10.1159/000076048 SCHUKNECHT HF, 1986, ARCH OTO-RHINO-LARYN, V243, P1, DOI 10.1007/BF00457899 SCHUMANN K, 1990, HNO, V38, P408 SHAIA FT, 1976, LARYNGOSCOPE, V86, P389, DOI 10.1288/00005537-197603000-00008 SHIKOWITZ MJ, 1991, MED CLIN N AM, V75, P1239 SIEGEL LG, 1975, OTOLARYNG CLIN N AM, V8, P467 SUJANA S, 2003, OPER TECHN OTOLARYNG, V14, P288 SUZUKI M, 1995, ANN OTO RHINOL LARYN, V104, P69 TAKAHASHI H, 1990, HYPERBARIC MED, P249 Topuz E, 2004, EUR ARCH OTO-RHINO-L, V261, P393, DOI 10.1007/s00405-003-0688-6 Vavrina J, 1995, Rev Laryngol Otol Rhinol (Bord), V116, P377 WILSON WR, 1983, OTOLARYNG HEAD NECK, V91, P653 Wilson WR, 1993, OTOLARYNGOLOGY HEAD, P3103 NR 39 TC 10 Z9 10 PU B C DECKER INC PI HAMILTON PA 50 KING STREET EAST, 2ND FLOOR, PO BOX 620, L C D 1, HAMILTON, ONTARIO L8N 3K7, CANADA SN 0381-6605 J9 J OTOLARYNGOL JI J. Otolaryngol. PD FEB PY 2007 VL 36 IS 1 BP 32 EP 37 DI 10.2310/7070.2006.0061 PG 6 WC Otorhinolaryngology SC Otorhinolaryngology GA 185DA UT WOS:000247690300006 PM 17376348 ER PT J AU Stettner, GM Rostasy, KM Ludwig, HC Merkler, D Fahsold, R Gartner, J AF Stettner, G. M. Rostasy, K. M. Ludwig, H. C. Merkler, D. Fahsold, R. Gaertner, J. TI Infratentorial meningioma in an 8-year-old child as first sign of neurofibromatosis type 2 SO NEUROPEDIATRICS LA English DT Article DE meningioma; neurofibromatosis type 2; NF2; childhood ID NF2 AB Meningiomas are rare intracranial tumors in pediatric patients. In contrast to meningiomas in adults, childhood ones have a poorer prognosis because of their high growth potential and tendency to recur. Meningiomas are often associated with neurofibromatosis type 2 (NF2) which is an autosomal-dominant disorder. In contrast to adults who primarily present with symptoms due to vestibular tumors, the initial symptoms in children with NF2 are subtle skin tumors, posterior capsular cataracts, or neurological signs secondary to cranial nerve(s) schwannoma excluding vestibular nerve, and/or brainstem or spinal cord compression. Here we report on the clinical, radiological, and histological findings in an 8-year-old boy who was diagnosed with an isolated infratentorial meningioma and a novel splice site mutation in the NF2 gene. The same mutation was detected in the boy's mother who suffered from hearing loss and tinnitus due to a bilateral vestibular schwannoma. Our patient demonstrates the need for molecular testing for NF2 gene mutations even in isolated childhood meningiomas although they do not fulfill the clinical criteria of NF2. C1 Univ Gottingen, Dept Pediat & Pediat Neurol, D-37075 Gottingen, Germany. Univ Gottingen, Dept Neurosurg, D-3400 Gottingen, Germany. Univ Gottingen, Dept Neuropathol, D-3400 Gottingen, Germany. Lab Prager & Junge Med Genet, Dresden, Germany. RP Stettner, GM (reprint author), Univ Gottingen, Dept Pediat & Pediat Neurol, Robert Koch Str 40, D-37075 Gottingen, Germany. EM georg.stettner@med.uni-goettingen.de CR Baser ME, 2004, AM J HUM GENET, V75, P231, DOI 10.1086/422700 Baser ME, 2005, J MED GENET, V42, P540, DOI 10.1136/jmg.2004.029504 Di Rocco C, 1999, CRIT REV NEUROSURG, V9, P180, DOI 10.1007/s003290050129 EVANS DGR, 1992, Q J MED, V84, P603 Evans DGR, 1999, ARCH DIS CHILD, V81, P496 Kluwe L, 1998, HUM MOL GENET, V7, P2051, DOI 10.1093/hmg/7.13.2051 Perry A, 2001, J NEUROPATH EXP NEUR, V60, P994 Ruggieri M, 2005, NEUROPEDIATRICS, V36, P21, DOI 10.1055/s-2005-837581 NR 8 TC 4 Z9 4 PU GEORG THIEME VERLAG KG PI STUTTGART PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY SN 0174-304X J9 NEUROPEDIATRICS JI Neuropediatrics PD FEB PY 2007 VL 38 IS 1 BP 29 EP 31 DI 10.1055/s-2007-980204 PG 3 WC Clinical Neurology; Pediatrics SC Neurosciences & Neurology; Pediatrics GA 189OS UT WOS:000247999000007 PM 17607601 ER PT J AU Bartels, H Staal, MJ Albers, FWJ AF Bartels, Hilke Staal, Michiel J. Albers, Frans W. J. TI Tinnitus and neural plasticity of the brain SO OTOLOGY & NEUROTOLOGY LA English DT Article DE auditory pathways; neural plasticity; nonclassical pathways; reorganization process; tinnitus ID DORSAL COCHLEAR NUCLEUS; INTENSE SOUND EXPOSURE; RECEPTOR ORGAN DAMAGE; HUMAN AUDITORY-CORTEX; GAZE-EVOKED TINNITUS; INFERIOR COLLICULUS; CORTICAL REORGANIZATION; ACOUSTIC TRAUMA; RESPONSE PROPERTIES; GUINEA-PIG AB Objective: To describe the current ideas about the manifestations of neural plasticity in generating tinnitus. Data Sources: Recently published source articles were identified using MEDLINE, PubMed, and Cochrane Library according to the key words mentioned below. Study Selection: Review articles and controlled trials were particularly selected. Data Extraction: Data were selected systematically, scaled on validity and comparability. Conclusion: An altered afferent input to the auditory pathway may be the initiator of a complex sequence of events, finally resulting in the generation of tinnitus at the central level of the auditory nervous system. The effects of neural plasticity can generally be divided into early modifications and modifications with a later onset. The unmasking of dormant synapses, diminishing of (surround) inhibition and initiation of generation of new connections through axonal sprouting are early manifestations of neural plasticity, resulting in lateral spread of neural activity and development of hyperexcitability regions in the central nervous system. The remodeling process of tonotopic receptive fields within auditory pathway structures (dorsal cochlear nucleus, inferior colliculus, and the auditory cortex) are late manifestations of neural plasticity. The modulation of tinnitus by stimulating somatosensory or visual systems in some people with tinnitus might be explained via the generation of tinnitus following the nonclassical pathway. The similarities between the pathophysiological processes of phantom pain sensations and tinnitus have stimulated the theory that chronic tinnitus is an auditory phantom perception. C1 Univ Groningen, Univ Med Ctr Groningen, Dept Otorhinolaryngol, NL-9700 AB Groningen, Netherlands. Univ Groningen, Med Ctr, Dept Neurosurg, NL-9700 AB Groningen, Netherlands. Univ Utrecht, Med Ctr, Dept Otorhinolaryngol, NL-3508 TC Utrecht, Netherlands. RP Bartels, H (reprint author), Univ Groningen, Univ Med Ctr Groningen, POB 30 001, NL-9700 RB Groningen, Netherlands. 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Neurotol. PD FEB PY 2007 VL 28 IS 2 BP 178 EP 184 DI 10.1097/MAO.0b013e31802b3248 PG 7 WC Clinical Neurology; Otorhinolaryngology SC Neurosciences & Neurology; Otorhinolaryngology GA 131DB UT WOS:000243847300005 PM 17255884 ER PT J AU Riga, M Papadas, T Werner, JA Dalchow, CV AF Riga, Maria Papadas, Thedoros Werner, Jochen A. Dalchow, Carsten V. TI A clinical study of the efferent auditory system in patients with normal hearing who have acute tinnitus SO OTOLOGY & NEUROTOLOGY LA English DT Article DE contralateral suppression; distortion product; efferent; tinnitus ID EVOKED OTOACOUSTIC EMISSIONS; MEDIAL OLIVOCOCHLEAR SYSTEM; CONTRALATERAL WHITE-NOISE; ACOUSTIC STIMULATION; SOUND STIMULATION; COCHLEAR NUCLEUS; SUPPRESSION; HUMANS; MECHANISMS; EARS AB Objective: Etiological diagnosis and treatment of tinnitus still remain challenging in clinical practice. The aim of this study was to determine the potential contribution of a defective cochlear efferent innervation to the onset of tinnitus in patients with normal hearing. Study Design: Prospective randomized controlled study. Setting: Otorhitiolaryngology department of a general hospital. Patients: The patient group consisted of 18 normal-hearing adults (7 men, 11 women) with acute tinnitus (bilateral in 3 patients). Interventions: Tympanogram, stapedial muscle reflex, pure tone audiometry, tinnitus pitch matching, spontaneous otoacoustic emissions, and distortion product otoacoustic emissions (DPOAEs) in the absence and presence of contralateral suppression by white noise. Main Outcome Measure: DPOAEs suppression amplitudes recorded from tinnitus and nontinnitus ears of the patients' group were compared with each other and with a control group. Results: The contralateral application of white noise induced the enhancement of DPOAE amplitudes in some patients. The suppression of DPOAE amplitudes by contralateral white noise did not reach statistically significant levels in either ear (with or without tinnitus). On the contrary, under the same conditions, our control group demonstrated statistically significant reduction of DPOAE amplitudes at all frequencies. Conclusion: Patients with normal hearing acuity who have acute tinnitus seem to have a less effective functioning of the cochlear efferent system because the application of contralateral noise enhanced the DPOAEs or suppressed them less intensely than it did in a control group. Further studies may establish the clinical applications for the diagnosis of changes in efferent function, in the subjective evaluation, patient etiological grouping, treatment, or prognosis of tinnitus. C1 Univ Patras, Dept Otorhinolaryngol Head & Neck Surg, GR-26110 Patras, Greece. Univ Marburg, Dept Otorhinolaryngol Head & Neck Surg, D-35032 Marburg, Germany. RP Dalchow, CV (reprint author), HNO Klin, Pk Klin Weissensee,Schon Str 80, D-13086 Berlin, Germany. EM dalchow@park-klinik.com CR ARNESEN AR, 1984, ACTA OTO-LARYNGOL, V98, P501, DOI 10.3109/00016488409107591 Attias J, 1996, ACTA OTO-LARYNGOL, V116, P534, DOI 10.3109/00016489609137885 Baguley DM, 2002, CLIN OTOLARYNGOL, V27, P219, DOI 10.1046/j.1365-2273.2002.00566.x Bauer Carol A, 2004, Curr Opin Otolaryngol Head Neck Surg, V12, P413, DOI 10.1097/01.moo.0000134443.29853.09 BERLIN CI, 1994, OTOLARYNG HEAD NECK, V110, P3, DOI 10.1016/S0194-5998(94)70788-X Brozoski TJ, 2002, J NEUROSCI, V22, P2383 BURNS EM, 1993, HEARING RES, V67, P117, DOI 10.1016/0378-5955(93)90239-W Caspary DM, 2001, NOISE INDUCED HEARIN, P169 CHERYCROZE S, 1993, HEARING RES, V68, P53, DOI 10.1016/0378-5955(93)90064-8 CHERYCROZE S, 1994, BRIT J AUDIOL, V28, P13, DOI 10.3109/03005369409077909 CHERYCROZE S, 1993, ACTA OTO-LARYNGOL, V113, P285, DOI 10.3109/00016489309135810 COLLET L, 1992, AUDIOLOGY, V31, P1 Di Girolamo S, 2001, HEARING RES, V162, P80, DOI 10.1016/S0378-5955(01)00370-7 Eggermont J. 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Neurotol. PD FEB PY 2007 VL 28 IS 2 BP 185 EP 190 DI 10.1097/MAO.0b013e31802e2a14 PG 6 WC Clinical Neurology; Otorhinolaryngology SC Neurosciences & Neurology; Otorhinolaryngology GA 131DB UT WOS:000243847300006 PM 17255885 ER PT J AU Baugh, A Hillman, TA Shelton, C AF Baugh, Andrew Hillman, Todd A. Shelton, Clough TI Combined petrosal approaches in the management of temporal bone meningiomas SO OTOLOGY & NEUROTOLOGY LA English DT Article DE meningioma; combined petrosal; retrolabyrinthine; transcochlear; cranial base ID PETROCLIVAL MENINGIOMAS; CEREBELLOPONTINE ANGLE; TUMORS; EXPERIENCE; LESIONS AB Objectives: To evaluate the indications and outcomes of the combined petrosal approaches in the surgical management of temporal bone meningiomas. Study Design: Retrospective chart review. Setting: University teaching hospital. Patients: Adults with temporal bone meningiomas. Intervention(s): Meningioma removal using a combined petrosal approach. Main Outcome Measure(s): Cranial nerve outcomes, complications, completeness of resection, and recurrence rates. Results: Forty-nine patients underwent surgical excision of a temporal bone meningioma between 1996 and 2004 at our institution. Nineteen of these patients required a combined petrosal approach for excision. The most common presenting complaints were balance disturbance, 11 (58%); hearing loss, 10 (53%); headache, 10 (53%); and tinnitus, 9 (47%). The most common tumor origin was of the petrous ridge (14; 74%). Average tumor size was 3.1 cm. Complete resection was possible in 17 (89%) patients. Upper cranial nerve (III-VI) function was improved in two (11%) patients and worsened in three (16%) patients. Lower cranial nerve (IX-XII) function improved in one (5%) patient and was worsened in one (5%) patient. Postoperative facial nerve function was Grades I to 11 in 16 (84%) patients and Grades III to IV in 1 (5%) patient at last follow-up. Hearing data were available in 14 patients. Of those patients, 11 (85%) had serviceable hearing after surgery. The most common surgical complication was a cerebrospinal fluid leak, with three (16%) incidences. There were no reported incidents of stroke, death, or meningitis in the cohort. Conclusion: The use of the combined petrosal approach for temporal bone meningioma resection results in favorable outcomes for the patient. The incidence of complications is acceptably low, and cure rates are high. C1 Pittsburgh Ear Associates, Pittsburgh, PA 15212 USA. Univ Utah, Sch Med, Salt Lake City, UT USA. Univ Utah, Div Otolaryngol, Salt Lake City, UT USA. RP Hillman, TA (reprint author), Pittsburgh Ear Associates, 420 E North Ave Ste 402, Pittsburgh, PA 15212 USA. EM todd_hillman@hotmail.com CR ARRIAGA M, 1992, OTOLARYNG HEAD NECK, V107, P738 ARRIAGA MA, 1991, AM J OTOL, V12, P470 Aziz KMA, 2000, NEUROSURGERY, V47, P139, DOI 10.1097/00006123-200007000-00030 BRACKMANN DE, 1980, OTOLARYNG HEAD NECK, V88, P555 Committee on Hearing and Equilibrium, 1995, OTOLARYNGOL HEAD NEC, V113, P179 Couldwell WT, 1996, J NEUROSURG, V84, P20, DOI 10.3171/jns.1996.84.1.0020 DASPIT CP, 1991, OTOLARYNG HEAD NECK, V105, P788 MANIGLIA AJ, 1978, LARYNGOSCOPE, V88, P1 McElveen JT, 2001, OTOLARYNG CLIN N AM, V34, P1219, DOI 10.1016/S0030-6665(05)70375-3 Megerian CA, 1996, AM J OTOL, V17, P773 PENSAK ML, 1994, LARYNGOSCOPE, V104, P814 Raut V, 2002, CLIN OTOLARYNGOL, V27, P147, DOI 10.1046/j.1365-2273.2002.00549.x Selesnick SH, 1996, AM J OTOL, V17, P793 NR 13 TC 3 Z9 5 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1531-7129 J9 OTOL NEUROTOL JI Otol. Neurotol. PD FEB PY 2007 VL 28 IS 2 BP 236 EP 239 DI 10.1097/01.mao.0000244361.32073.e0 PG 4 WC Clinical Neurology; Otorhinolaryngology SC Neurosciences & Neurology; Otorhinolaryngology GA 131DB UT WOS:000243847300016 PM 17159495 ER PT J AU Seydel, C Klapp, BF Mazurek, B AF Seydel, C. Klapp, B. F. Mazurek, B. TI Results of an outpatient multimodal tinnitus short-term therapy - Modification of psychometric parameters SO PSYCHOTHERAPIE PSYCHOSOMATIK MEDIZINISCHE PSYCHOLOGIE LA German DT Meeting Abstract ID DECOMPENSATED TINNITUS; STRESS C1 Univ Med Berlin, Charite, Med Klin Mit Schwerpunkt Psychosomat, Berlin, Germany. Univ Med Berlin, HNO Klin, Charite, Campus Mitte, Berlin, Germany. CR Andersson G, 2002, CLIN PSYCHOL REV, V22, P977, DOI 10.1016/S0272-7358(01)00124-6 CAFFIER PP, 2006, EAR HEARING Delb W, 2002, HNO, V50, P997, DOI 10.1007/s00106-002-0645-5 Fliege H, 2005, PSYCHOSOM MED, V67, P78, DOI 10.1097/01.psy.0000151491.80178.78 Goebel G, 1998, INSTRUMENT ERFASSUNG Harter M, 2004, HNO, V52, P125, DOI 10.1007/s00160-003-0889-8 Hautzinger M, 1993, ALLGEMEINE DEPRESSIO Henry JA, 2005, J SPEECH LANG HEAR R, V48, P1204, DOI 10.1044/1092-4388(2005/084) JASTREBOFF PJ, 1993, BRIT J AUDIOL, V27, P7, DOI 10.3109/03005369309077884 Kroner-Herwig B., 1997, PSYCHOL BEHANDLUNG C LEVENSTEIN S, 1993, PERCEIVED STRESS QUE Mazurek B, 2005, GESUNDHEITSWESEN, V67, P485, DOI 10.1055/s-2005-858379 Seydel C, 2006, HNO, V54, P709, DOI 10.1007/s00106-006-1445-0 Stobik C, 2003, PSYCHOTHER PSYCH MED, V53, P344 Stobik C, 2005, INT J AUDIOL, V44, P370, DOI 10.1080/14992020500147557 Weber C, 2002, J PSYCHOSOM RES, V52, P29, DOI 10.1016/S0022-3999(01)00281-1 Zumbaum-Fischer FO, 2005, PSYCHOTHER PSYCH MED, V55, P160 NR 17 TC 0 Z9 0 PU GEORG THIEME VERLAG KG PI STUTTGART PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY SN 0937-2032 J9 PSYCHOTHER PSYCH MED JI Psychother. Psychosom. Med. Psychol. PD FEB PY 2007 VL 57 IS 2 MA 096 BP 106 EP 107 PG 2 WC Psychology, Clinical SC Psychology GA 152DU UT WOS:000245341800103 ER PT J AU Plewnia, C Bischof, F Reimold, M AF Plewnia, Christian Bischof, Felix Reimold, Matthias TI Suppression of verbal hallucinations and changes in regional cerebral blood flow after intravenous lidocaine: A case report SO PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY LA English DT Review DE lidocaine; PET; rCBF; verbal hallucinations ID AUDITORY HALLUCINATIONS; MUSICAL HALLUCINATIONS; DOUBLE-BLIND; SCHIZOPHRENIA; PHENOMENOLOGY; TINNITUS; SPECTRUM AB Simple and complex auditory phantom-perceptions such as tinnitus and musical hallucinations occur predominantly in elderly subjects and are often associated with hearing impairment. Isolated verbal hallucinations without other psychotic features are rare. It has been shown that an intravenous (i.v.) injection of lidocame can transiently suppress tinnitus. Here we present the case of a 74 year old left-handed women with severely distressing, continuous verbal auditory hallucinations without other psychotic features. I.v. injections of 100 mg lidocame but not saline resulted in substantial transient suppressions of the hallucinations for several hours. Using [(15)O]H(2)O positron-emission tomography (PET) decreased regional cerebral blood flow associated with reduced perception of voices was found in the right angular and supramarginal gyrus, right inferior frontal gyrus, orbitofronal cortex and in major parts of the cingulate cortex. These data suggest to further investigate the clinical relevance of i.v. lidocaine in patients with therapy-resistant verbal hallucinations, support the notion of common pathophysiological mechanisms in different forms of auditory phantom-perception and demonstrate the feasibility of a new strategy for imaging studies on auditory hallucinations. (c) 2006 Elsevier Inc. All rights reserved. C1 Univ Tubingen, Dept Psychiat & Psychotherapy, D-72076 Tubingen, Germany. Univ Tubingen, Hertie Inst Clin Brain Res, Dept Gen Neurol, D-72076 Tubingen, Germany. Univ Tubingen, Dept Nucl Med, D-72076 Tubingen, Germany. Univ Tubingen, PET Ctr, D-72076 Tubingen, Germany. RP Plewnia, C (reprint author), Univ Tubingen, Dept Psychiat & Psychotherapy, Osianderstr 24, D-72076 Tubingen, Germany. EM christian.plewnia@uni-tuebingen.de RI Plewnia, Christian/D-1652-2015 CR Attal N, 2000, NEUROLOGY, V54, P564 Baguley DM, 2005, OTOL NEUROTOL, V26, P169, DOI 10.1097/00129492-200503000-00007 BERRIOS GE, 1990, BRIT J PSYCHIAT, V156, P188, DOI 10.1192/bjp.156.2.188 Chevrier P, 2004, BRIT J PHARMACOL, V142, P576, DOI 10.1038/sj.bjp.0705796 Cole MG, 2002, INT J GERIATR PSYCH, V17, P444, DOI 10.1002/gps.618 Eggermont JJ, 2004, TRENDS NEUROSCI, V27, P676, DOI 10.1016/j.tins.2004.08.010 Evers S, 2004, J NEUROL SCI, V227, P55, DOI 10.1016/j.jns.2004.08.004 Fischer CE, 2004, PSYCHIAT CLIN NEUROS, V58, P96 FOLSTEIN MF, 1975, J PSYCHIAT RES, V12, P189, DOI 10.1016/0022-3956(75)90026-6 Griffiths TD, 2000, BRAIN, V123, P2065, DOI 10.1093/brain/123.10.2065 Izumi Y, 2002, PSYCHIAT RES-NEUROIM, V116, P119, DOI 10.1016/S0925-4927(02)00083-5 Lennox BR, 2000, PSYCHIAT RES-NEUROIM, V100, P13, DOI 10.1016/S0925-4927(00)00068-8 Pasquini F, 1997, J GERIATR PSYCH NEUR, V10, P11 PLEWNIA C, 2006, HUM BRAIN MAPP, DOI DOI 10.1002/HBM.20270 Shergill SS, 2000, ARCH GEN PSYCHIAT, V57, P1033, DOI 10.1001/archpsyc.57.11.1033 SILBERSWEIG DA, 1995, NATURE, V378, P176, DOI 10.1038/378176a0 Stephane M, 2000, J NEUROPSYCH CLIN N, V12, P286, DOI 10.1176/appi.neuropsych.12.2.286 WHO, 1993, ICD 10 CLASS MENT BE WILKING SV, 1987, J AM GERIATR SOC, V35, P346 NR 19 TC 3 Z9 3 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0278-5846 J9 PROG NEURO-PSYCHOPH JI Prog. Neuro-Psychopharmacol. Biol. Psychiatry PD JAN 30 PY 2007 VL 31 IS 1 BP 301 EP 303 DI 10.1016/j.pnpbp.2006.08.014 PG 3 WC Clinical Neurology; Neurosciences; Pharmacology & Pharmacy; Psychiatry SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry GA 129OE UT WOS:000243738000045 PM 17011097 ER PT J AU Thomas, B Kesavadas, C AF Thomas, Bejoy Kesavadas, Chandrasekharan TI An unusual case of pulsatile tinnitus and deafness SO NEUROLOGY LA English DT Editorial Material ID JUGULAR BULB DIVERTICULA C1 Sree Chitra Tirunal Inst Med Sci & Technol, Dept Imaging Sci & Intervent Radiol, Trivandrum 695011, Kerala, India. RP Thomas, B (reprint author), Sree Chitra Tirunal Inst Med Sci & Technol, Dept Imaging Sci & Intervent Radiol, Trivandrum 695011, Kerala, India. EM drbejoy2002@yahoo.com CR Bilgen C, 2003, OTOLARYNG HEAD NECK, V128, P382, DOI 10.1067/mhn.2003.32 PRESUTTI L, 1991, ORL J OTO-RHINO-LARY, V53, P57 NR 2 TC 0 Z9 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0028-3878 J9 NEUROLOGY JI Neurology PD JAN 23 PY 2007 VL 68 IS 4 BP 303 EP 303 DI 10.1212/01.wnl.0000243244.07887.01 PG 1 WC Clinical Neurology SC Neurosciences & Neurology GA 128EA UT WOS:000243639800016 PM 17242340 ER PT J AU Siedentopf, CM Ischebeck, A Haala, IA Mottaghy, FM Schikora, D Verius, M Koppelstatter, F Buchberger, W Schlager, A Felber, SR Golaszewski, SM AF Siedentopf, Christian M. Ischebeck, Anja Haala, Ilka A. Mottaghy, Felix M. Schikora, Detlef Verius, Michael Koppelstatter, Florian Buchberger, Waltraud Schlager, Andreas Felber, Stephan R. Golaszewski, Stefan M. TI Neural correlates of transmeatal cochlear laser (TCL) stimulation in healthy human subjects SO NEUROSCIENCE LETTERS LA English DT Article DE laser; TCL; tinnitus; fMRI ID HELIUM-NEON LASER; LOW-POWER LASER; TINNITUS; THERAPY; ACUPUNCTURE; IRRADIATION; PERCEPTION; CORTEX; MODEL AB Transmeatal cochlear laser (TCL) treatment has recently been proposed as a therapeutic procedure for cochlear dysfunction such as chronic cochlear tinnitus or sensorineural hearing loss. The aim of this study was to investigate whether TLC has any influence on the central nervous system using functional MRI with healthy young adults. The laser stimulation device was placed on the tympanic membrane of both ears. A laser stimulation run and a placebo run were performed in random order. The participants were unable to differentiate between verum and placebo stimulation. In the comparison of verum to placebo runs, we observed significant activations within the left superior frontal gyrus, the right middle and medial frontal gyrus, the right superior parietal lobule, the left superior occipital gyrus, the precuneus and cuneus bilaterally, the right anterior and the left and right middle and posterior cingulate gyrus and the left thalamus. This network of brain areas corresponds well to results from previous PET studies of patients with tinnitus. Though TCL seems to have a clinically measurable effect on the central nervous system the neurophysiological mechanism leading to the observed activated neuronal network remains unknown. (c) 2006 Elsevier Ireland Ltd. All rights reserved. C1 Med Univ Innsbruck, Dept Radiol 2, Div Neuroradiol, Univ Hosp Innsbruck, A-6020 Innsbruck, Austria. Med Univ Innsbruck, fMRI Lab, Dept Psychiat, A-6020 Innsbruck, Austria. Med Univ Innsbruck, Dept Neurol, A-6020 Innsbruck, Austria. Univ Hosp Ulm, Dept Nucl Med, Ulm, Germany. Univ Paderborn, Dept Phys & Optoelectron, Paderborn, Germany. Univ Hlth Sci Med Informat & Technol, Inst Hlth Sci, Innsbruck, Austria. Med Univ Innsbruck, Dept Anaesthesiol & Crit Care Med, A-6020 Innsbruck, Austria. RP Siedentopf, CM (reprint author), Med Univ Innsbruck, Dept Radiol 2, Div Neuroradiol, Univ Hosp Innsbruck, Anichstr 35, A-6020 Innsbruck, Austria. EM christian.siedentopf@fmri-easy.de CR Andersson G, 2002, CLIN PSYCHOL REV, V22, P977, DOI 10.1016/S0272-7358(01)00124-6 Cacace AT, 1999, AUDIOL NEURO-OTOL, V4, P258, DOI 10.1159/000013849 Gerken GM, 1996, HEARING RES, V97, P75 Giraud AL, 1999, NEUROREPORT, V10, P1, DOI 10.1097/00001756-199901180-00001 Hans HFI, 1992, LASER SURG MED, V12, P528, DOI 10.1002/lsm.1900120512 JASTREBOFF PJ, 1990, NEUROSCI RES, V8, P221, DOI 10.1016/0168-0102(90)90031-9 Jastreboff PJ, 2003, OTOLARYNG CLIN N AM, V36, P321, DOI 10.1016/S0030-6665(02)00172-X JASTREBOFF PJ, 1988, LARYNGOSCOPE, V98, P280 Karu T. 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V., 1995, ADV OTORHINOLARYNGOL, V49, P105 Wilden L., 1996, Laser Therapy, V8, P209 Yu W., 1994, LASERS SURG MED S, V6, P8 ZENNER HP, 1993, EUR ARCH OTO-RHINO-L, V249, P447 NR 34 TC 14 Z9 15 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0304-3940 J9 NEUROSCI LETT JI Neurosci. Lett. PD JAN 16 PY 2007 VL 411 IS 3 BP 189 EP 193 DI 10.1016/j.neulet.2006.08.049 PG 5 WC Neurosciences SC Neurosciences & Neurology GA 134JC UT WOS:000244078300006 PM 17123710 ER PT J AU Hebert, S Lupien, SJ AF Hebert, Sylvie Lupien, Sonia J. TI The sound of stress: Blunted cortisol reactivity to psychosocial stress in tinnitus sufferers SO NEUROSCIENCE LETTERS LA English DT Article DE Trier Social Stress Test; tinnitus; stress; cortisol; HPA axis ID PITUITARY-ADRENAL AXIS; CHRONIC-FATIGUE-SYNDROME; MULTIPLE-SCLEROSIS; MENIERES-DISEASE; LIFE EVENTS; DEPRESSION; RESPONSES; PAIN; HYPOCORTISOLISM; CORTICOTROPIN AB Clinical observations suggest that tinnitus is modulated by stress. However, there is little empirical data to support the link between stress and tinnitus. In this study, we measured the stress hormone cortisol to examine the reactivity of the hypothalamic-pituitary-adrenal (HPA) axis in tinnitus participants as well as in healthy controls without tinnitus. Eighteen participants with tinnitus and 18 controls without tinnitus were exposed to the Trier Social Stress Task and cortisol sampling and subjective ratings were obtained at regular intervals. Tinnitus participants displayed a blunted cortisol response to psychosocial stress, in comparison with healthy controls who had a typical cortisol release about 30 min after the beginning of the experiment. The blunted cortisol response displayed by the tinnitus participants suggests that they have an anomaly along the HPA axis. Their cortisol response is similar to that found in other bodily stress-related diseases and thus suggests that tinnitus is related to stress. However, tinnitus intensity might not be modulated by stress in a concurrent manner. (c) 2006 Elsevier Ireland Ltd. All rights reserved. C1 Univ Montreal, Ecole Orthophonie & Audiol, Montreal, PQ H3C 3J7, Canada. Univ Montreal, Inst Geriatr, Ctr Rech, Montreal, PQ, Canada. McGill Univ, Dept Psychiat, Montreal, PQ H3A 2T5, Canada. McGill Univ, Ctr Studies Human Stress, Douglas Hosp Res Ctr, Montreal, PQ H3A 2T5, Canada. RP Hebert, S (reprint author), Univ Montreal, Ecole Orthophonie & Audiol, Montreal, PQ H3C 3J7, Canada. 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Lett. PD JAN 10 PY 2007 VL 411 IS 2 BP 138 EP 142 DI 10.1016/j.neulet.2006.10.028 PG 5 WC Neurosciences SC Neurosciences & Neurology GA 129QK UT WOS:000243743800011 PM 17084027 ER PT J AU Myrseth, E Pedersen, PH Moller, P Lund-Johansen, M AF Myrseth, E. Pedersen, P.-H. Moller, P. Lund-Johansen, M. TI Treatment of vestibular schwannomas. Why, when and how? SO ACTA NEUROCHIRURGICA LA English DT Review DE vestibular schwannoma; microsurgery; radiosurgery; quality of life ID QUALITY-OF-LIFE; ACOUSTIC NEUROMA SURGERY; GAMMA-KNIFE RADIOSURGERY; SF-36 HEALTH SURVEY; FACIAL-NERVE OUTCOMES; SUDDEN HEARING-LOSS; CONSERVATIVE MANAGEMENT; NATURAL-HISTORY; LEARNING-CURVE; STEREOTACTIC RADIOSURGERY AB Sporadic vestibular schwannoma (VS) causes unilateral hearing loss, tinnitus, vertigo and unsteadiness. In many cases, the tumour size may remain unchanged for many years following diagnosis, which is typically made by MRI. In the majority of cases the tumour is small, leaving, the clinician and patient with the options of either serial scanning or active treatment by gamma knife radiosurgery (GKR) or microneurosurgery. Despite the vast number of published treatment reports, comparative studies are few, and evidence is no better than class III (May, 2006). The predominant clinical endpoints of VS treatment include turnout control, facial nerve function and hearing preservation. Less focus has been put on symptom relief and health-related quality of life (QOL). It is uncertain if treating a small tumour leaves the patient with a better chance of obtaining relief from future hearing loss, vertigo or tinnitus than by observing it without treatment. Recent data indicate that QOL is reduced in untreated VS patients, and may differ between patients who have been operated and patients treated with GKR. In the present paper we review the natural course arid complaints of untreated VS patients, and the treatment alternatives and results. Furthermore, we review the literature concerning quality of life in patients with VS. Finally, we present our experience with a management strategy applied to more than 300 cases since 2001. C1 Univ Bergen, Haukeland Univ Hosp, Inst Surg Sci, Dept Neurosurg, Bergen, Norway. Univ Bergen, Haukeland Univ Hosp, Inst Surg Sci, Dept Otorhinolaryngol, Bergen, Norway. RP Myrseth, E (reprint author), Univ Bergen, Haukeland Univ Hosp, Inst Surg Sci, Dept Neurosurg, Bergen, Norway. 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TI Microvascular decompression as a treatment for cranial nerve hyperactive dysfunction - a critical view SO ACTA NEUROLOGICA SCANDINAVICA LA English DT Article; Proceedings Paper CT Annual Meeting of the Norwegian-Neurological-Association (Nevrodagene 2006) CY NOV 20-24, 2006 CL Oslo, NORWAY SP Norwegian Neurol Assoc DE trigeminal neuralgia; microvascular decompression; vertigo; magnetic resonance angiography; treatment ID MAGNETIC-RESONANCE ANGIOGRAPHY; DISABLING POSITIONAL VERTIGO; TRIGEMINAL NEURALGIA; VASCULAR COMPRESSION; MULTIPLE-SCLEROSIS; NEUROVASCULAR COMPRESSION; OUTCOMES; CONTACT; SURGERY; ROOT AB Neurovascular compression has been postulated as a probable mechanism for a large number of cranial nerve syndromes, with trigeminal neuralgia (TGN) as the prime example. Microvascular decompression (MVD) is often cited as the procedure of choice for treatment of medically refractory TGN. Arguments against these assumptions are: MRA studies indicate that vascular contact with the trigeminal nerve is present in most healthy individuals. Treatment results of MVD in multiple sclerosis patients with TGN are almost as good (at least in the short term) as in idiopathic cases. MVD is reported to provide pain relief even in TGN patients without visible neurovascular contact . In other syndromes of cranial nerve'hyperactive dysfunction'- vertigo, tinnitus and neurogenic hypertension - the documentation is even weaker. C1 Spesialistsenteret AS, N-4611 Kristiansand, Norway. RP Monstad, P (reprint author), Spesialistsenteret AS, Tollbodgt 4, N-4611 Kristiansand, Norway. 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Scand. PY 2007 VL 115 SU 187 BP 30 EP 33 DI 10.1111/j.1600-0404.2007.00857.x PG 4 WC Clinical Neurology SC Neurosciences & Neurology GA 152AK UT WOS:000245332300005 ER PT J AU Kim, CS Suh, MW AF Kim, Chong-Sun Suh, Myung-Whan TI Skull base surgery for removal of temporal bone tumors SO ACTA OTO-LARYNGOLOGICA LA English DT Article DE skull base; temporal bone; schwannoma; glomus tumor; squamous cell carcinoma ID INFRATEMPORAL FOSSA APPROACH; EXTERNAL AUDITORY MEATUS; FACIAL-NERVE SCHWANNOMA; SQUAMOUS-CELL CARCINOMA; GLOMUS TUMORS; MANAGEMENT; EXPERIENCE; EAR; PARAGANGLIOMAS; MALIGNANCY AB Conclusion. When selecting the appropriate surgical approach the pathological type of tumor, the physiological status as well as the functional aspects should be considered. Understanding the strengths and weaknesses of each surgical technique and knowledge of the particular tumor biology facilitates selection of the most appropriate surgical approach and a successful outcome. Objectives. The purpose of this study was to review cases that underwent skull base surgery for a variety of tumors that involved the temporal bone. We reviewed a single center's 25-year experience for epidemiologic characteristics, symptoms, treatment type and outcomes. Patients and Methods. The medical records and radiological images of 91 patients, who underwent skull base surgery, were retrospectively reviewed. Results. Among the 91 patients, 61 cases had benign disease and 30 had malignancies. A facial nerve schwannoma was the most common benign intratemporal tumor and a squamous cell carcinoma was the most common malignant tumor. With the facial nerve schwannoma, facial nerve paralysis and hearing loss were the most common presenting complaints; otalgia was the most common presenting symptom for temporal bone cancer. For patients with a glomus tumor, there was a characteristic pulsating tinnitus. A majority of the facial nerve schwannomas were resectable through the transmastoid approach. The infratemporal fossa approach type A was usually required for lower cranial nerve schwannomas and glomus jugulare tumors. However, the fallopian bridge technique with hypotympanectomy was another surgical option. Partial temporal bone resection and subtotal temporal bone resections were performed in cases with temporal bone cancer. The disease free 5-year survival of the temporal bone cancers was 42% and for the squamous cell carcinomas, it was 44%. C1 Seoul Natl Univ, Coll Med, Dept Otorhinolaryngol, Seoul 110799, South Korea. RP Kim, CS (reprint author), Seoul Natl Univ, Coll Med, Dept Otorhinolaryngol, Yongon Dong, Seoul 110744, South Korea. EM chongkim@snu.ac.kr CR Angeli SI, 1997, OTOLARYNGOL HEAD NEC, V117, P144 ARRIAGA M, 1990, ANN OTO RHINOL LARYN, V99, P714 BOJRAB DI, 1991, OTOLARYNG HEAD NECK, V104, P261 BRACKMANN DE, 1978, ANN OTO RHINOL LARYN, V87, P772 DORT JC, 1991, SKULL BASE SURG, V1, P51, DOI 10.1055/s-2008-1056979 ESTREM SA, 1993, OTOLARYNG CLIN N AM, V26, P231 FARR HW, 1967, AM J SURG, V114, P614, DOI 10.1016/0002-9610(67)90027-X FISCH U, 1978, J LARYNGOL OTOL, V92, P949, DOI 10.1017/S0022215100086382 FISCH U, 1984, OTOLARYNG CLIN N AM, V17, P513 GOODWIN WJ, 1980, ARCH OTOLARYNGOL, V106, P675 Gottfried Oren N, 2004, Neurosurg Focus, V17, pE4 HOUSE WF, 1963, ARCHIV OTOLARYNGOL, V78, P460 JACKSON CG, 1982, ARCH OTOLARYNGOL, V108, P401 Kim CS, 2003, OTOL NEUROTOL, V24, P312, DOI 10.1097/00129492-200303000-00030 KINNEY SE, 1989, AM J OTOL, V10, P111 KINNEY SE, 1984, OTOLARYNG HEAD NECK, V92, P94 KINNEY SE, 1987, LARYNGOSCOPE, V97, P158 Liu R, 2001, ANN OTO RHINOL LARYN, V110, P1025 Manolidis S, 1999, LARYNGOSCOPE, V109, P30, DOI 10.1097/00005537-199901000-00007 Manolidis S, 1998, AM J OTOL, V19, pS1 McCaffrey TV, 2001, OTOLARYNG CLIN N AM, V34, P837, DOI 10.1016/S0030-6665(05)70350-9 Moody SA, 2000, AM J OTOL, V21, P582 OLEARY MJ, 1991, LARYNGOSCOPE, V101, P1038 Pensak ML, 1997, OTOLARYNG HEAD NECK, V117, P586, DOI 10.1016/S0194-5998(97)70037-8 ROHIT JY, 2003, J LARYNGOL OTOL, V117, P462 Sanna M, 2004, OTOL NEUROTOL, V25, P797, DOI 10.1097/00129492-200409000-00025 SCHWABER MK, 1988, OTOLARYNG HEAD NECK, V98, P150 SPECTOR GJ, 1976, LARYNGOSCOPE, V86, P690, DOI 10.1288/00005537-197605000-00009 WILSON JSP, 1974, BRIT J PLAST SURG, V27, P77, DOI 10.1016/0007-1226(74)90066-6 NR 29 TC 1 Z9 1 PU TAYLOR & FRANCIS AS PI OSLO PA PO BOX 12 POSTHUSET, NO-0051 OSLO, NORWAY SN 0001-6489 J9 ACTA OTO-LARYNGOL JI Acta Oto-Laryngol. PY 2007 VL 127 SU 558 BP 4 EP 14 DI 10.1080/03655230701624806 PG 11 WC Otorhinolaryngology SC Otorhinolaryngology GA 212OC UT WOS:000249605700002 ER PT J AU Im, GJ Jung, HH Chae, SW Cho, WS Kim, SJ AF Im, Gi Jung Jung, Hak Hyun Chae, Sung Won Cho, Woo Sung Kim, Seo Jin TI Differential gene expression profiles in salicylate ototoxicity of the mouse SO ACTA OTO-LARYNGOLOGICA LA English DT Article DE cochlea; ototoxicity; salicylate; mouse ID INNER-EAR; PROTEIN; RECEPTOR; NEURONS; LOCALIZATION; HIPPOCAMPAL; MECHANISMS; SURVIVAL; BRAIN AB Conclusion. This study demonstrated differential gene expression profiles in salicylate ototoxicity with oligonucleotide microarray. This study may also provide basic information on candidate genes associated with hearing loss and/or tinnitus or recovery after salicylate-induced cochlear dysfunction. Objectives. Salicylate ototoxicity is accompanied by temporary hearing loss and tinnitus. The purpose of the present study was to evaluate the gene expression profiles in the mouse cochlea with salicylate ototoxicity using DNA microarray. Materials and methods. The subject mice were injected intraperitoneally with 400 mg/kg of sodium salicylate; an approximate 30 dB threshold shift that was observed by auditory brainstem response was achieved 3 h after an injection of sodium salicylate and the hearing threshold returned to within normal range at 3 days. Differential gene expression profiles at 3 h after salicylate injection in comparison to the normal cochlea were analyzed with DNA microarray technology. Results. No ultrastructural changes in the mice cochlea were observed by TEM at 3 h after salicylate injection. Microarray revealed that 87 genes were up-regulated twofold or more in the mouse cochlea with salicylate ototoxicity in comparison to the normal cochlea. Among these genes, increased expression levels of 30 functional genes were confirmed by semi-quantitative RT-PCR. C1 Korea Univ, Coll Med, Dept Otolaryngol Head & Neck Surg, Seoul 136705, South Korea. Korea Univ, Dept Biomed Sci, Seoul 136705, South Korea. RP Jung, HH (reprint author), Korea Univ, Coll Med, Dept Otolaryngol Head & Neck Surg, Amdong 5KA 126-1, Seoul 136705, South Korea. EM ranccoon@naver.com CR BARRES BA, 1992, CELL, V70, P31, DOI 10.1016/0092-8674(92)90531-G Brabet P, 1996, GENOMICS, V38, P100, DOI 10.1006/geno.1996.0600 Cazals Y, 2000, PROG NEUROBIOL, V62, P583, DOI 10.1016/S0301-0082(00)00027-7 DIDIER A, 1993, HEARING RES, V69, P199, DOI 10.1016/0378-5955(93)90108-D EDELHOFF S, 1995, MAMM GENOME, V6, P111, DOI 10.1007/BF00303253 Fukuda M, 2001, BIOCHEM J, V354, P249, DOI 10.1042/0264-6021:3540249 Hashimoto M, 2005, ACTA NEUROPATHOL, V109, P165, DOI 10.1007/s00401-004-0926-z Heller S, 2002, J NEUROBIOL, V53, P265, DOI 10.1002/neu.10122 Horie M, 2000, GENOMICS, V67, P146, DOI 10.1006/geno.2000.6228 Jiang M, 2004, CIRCULATION, V109, P1783, DOI 10.1161/01.CIR.0000124225.43852.50 JUNG TTK, 1995, ACTA OTO-LARYNGOL, V115, P251, DOI 10.3109/00016489509139302 Kadota Y, 1997, MOL BRAIN RES, V46, P265, DOI 10.1016/S0169-328X(97)00023-5 KASTING NW, 1984, NEUROENDOCRINOLOGY, V39, P201, DOI 10.1159/000123980 Kirkpatrick LL, 2000, J BIOL CHEM, V275, P17786, DOI 10.1074/jbc.M002254200 Kitajiri S, 2004, HEARING RES, V187, P25, DOI 10.1016/S0378-5955(03)00338-1 Lue AJC, 1999, HEARING RES, V135, P163, DOI 10.1016/S0378-5955(99)00102-1 MERCHANPEREZ A, 1990, EUR ARCH OTO-RHINO-L, V248, P4, DOI 10.1007/BF00634770 Mohn AR, 1997, MOL CELL NEUROSCI, V9, P63, DOI 10.1006/mcne.1997.0606 Morishita Y, 2004, J PHARMACOL SCI, V96, P276, DOI 10.1254/jphs.FMJ04004X7 Nesbit MA, 1997, GENOMICS, V42, P284, DOI 10.1006/geno.1997.4737 ODowd BF, 1996, FEBS LETT, V394, P325, DOI 10.1016/0014-5793(96)00901-5 OSEI YD, 1995, GENE, V155, P185, DOI 10.1016/0378-1119(94)00858-P Robertson NG, 1997, GENOMICS, V46, P345, DOI 10.1006/geno.1997.5067 Singec I, 2002, J COMP NEUROL, V452, P139, DOI 10.1002/cne.10371 STYPULKOWSKI PH, 1990, HEARING RES, V46, P113, DOI 10.1016/0378-5955(90)90144-E NR 25 TC 10 Z9 11 PU TAYLOR & FRANCIS AS PI OSLO PA PO BOX 12 POSTHUSET, NO-0051 OSLO, NORWAY SN 0001-6489 J9 ACTA OTO-LARYNGOL JI Acta Oto-Laryngol. PY 2007 VL 127 IS 5 BP 459 EP 469 DI 10.1080/00016480600801365 PG 11 WC Otorhinolaryngology SC Otorhinolaryngology GA 165WK UT WOS:000246337700002 PM 17453470 ER PT J AU Wilkinson, EP Meyer, TA Rubinstein, JT AF Wilkinson, Eric P. Meyer, Ted A. Rubinstein, Jay T. TI Spontaneous otogenic pneumocephalus managed with the middle fossa approach SO ACTA OTO-LARYNGOLOGICA LA English DT Article; Proceedings Paper CT 108th Annual Meeting of the American-Academy-of-Otolaryngology-Head-and-Neck-Surgery CY SEP 19-22, 2004 CL New York, NY SP Amer Acad Otolaryngol Head & Neck Surg DE skull base; mastoid; pneumocephalus; middle fossa approach; defect; otogenic; tinnitus ID DEFECTS AB Spontaneous otogenic pneumocephalus caused by barotrauma is extremely rare. We surveyed the literature and describe a case report of otogenic pneurnocephalus from barotrauma managed with a middle fossa craniotomy. The neurotologic literature review revealed three similar cases. We conclude that anatomic defects in the floor of the middle cranial fossa contribute to the development of spontaneous otogenic pneumocephalus. Neurotologic consultation should be obtained. In selected instances, middle fossa craniotomy may be required for repair. C1 House Ear Clin, Los Angeles, CA 90057 USA. Med Univ S Carolina, Dept Otorhinolaryngol Head & Neck Surg, Charleston, SC USA. Univ Washington, Dept Otolaryngol Head & Neck Surg, Virginia Merrill Bloedel Hearing Res Ctr, Seattle, WA 98195 USA. RP Wilkinson, EP (reprint author), House Ear Clin, W Third St, Los Angeles, CA 90057 USA. EM ewilkinson@hei.org CR Ajalloveyan M, 1998, AM J OTOL, V19, P824 ANDREWS JC, 1986, LARYNGOSCOPE, V96, P521, DOI 10.1288/00005537-198605000-00010 KAPUR TR, 1986, J LARYNGOL OTOL, V100, P1129, DOI 10.1017/S0022215100100702 LUNSFORD LD, 1979, J NEUROSURG, V50, P525, DOI 10.3171/jns.1979.50.4.0525 Merchant SN, 2000, AM J OTOL, V21, P234, DOI 10.1016/S0196-0709(00)80015-0 Vallejo LA, 1999, OTOLARYNG HEAD NECK, V121, P662, DOI 10.1016/S0194-5998(99)70080-X NR 6 TC 2 Z9 2 PU TAYLOR & FRANCIS AS PI OSLO PA PO BOX 12 POSTHUSET, NO-0051 OSLO, NORWAY SN 0001-6489 J9 ACTA OTO-LARYNGOL JI Acta Oto-Laryngol. PY 2007 VL 127 IS 8 BP 892 EP 896 DI 10.1080/00016480601053081 PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA 202CR UT WOS:000248880100019 PM 17763004 ER PT J AU Chuang, WC Short, JH McKinney, AM Anker, L Knoll, B McKinney, ZJ AF Chuang, W. C. Short, J. H. McKinney, A. M. Anker, L. Knoll, B. McKinney, Z. J. TI Reversible left hemispheric ischemia secondary to carotid compression in eagle syndrome: Surgical and CT angiographic correlation SO AMERICAN JOURNAL OF NEURORADIOLOGY LA English DT Article ID STYLOID PROCESS; ARTERY AB In 1937, Eagle described a pair of cases in which an elongated styloid process was associated with facial pain.(1) Since then, it has been recognized that uncommonly face and neck pain may be associated with an elongated styloid process. More uncommonly, symptoms such as dysphagia, tinnitus, and otalgia. may occur. Eagle syndrome is now thought to be due to 2 different subtypes,(2) the classic form resulting from cranial nerve impingement and the second type from impingement of the carotid vessels. C1 Hennepin Cty Med Ctr, Dept Radiol, Minneapolis, MN 55415 USA. Univ Minnesota, Sch Med, Dept Radiol, Minneapolis, MN 55455 USA. RP Short, JH (reprint author), Hennepin Cty Med Ctr, Dept Radiol, 701 Pk Ave S, Minneapolis, MN 55415 USA. EM xshort@yahoo.com CR Bafaqeeh SA, 2000, J OTOLARYNGOL, V29, P88 Baugh R F, 1993, Ear Nose Throat J, V72, P341 Eagle WW, 1937, ARCHIV OTOLARYNGOL, V25, P584 EAGLE WW, 1948, ARCH OTOLARYNGOL, V47, P630 EAGLE WW, 1949, ARCH OTOLARYNGOL, V49, P490 LENGELE BG, 1988, ARCH OTOLARYNGOL, V114, P1003 McKinney A, 2005, NEURORADIOLOGY, V47, P1, DOI 10.1007/s00234-004-1301-4 Rechtweg JS, 1998, AM J OTOLARYNG, V19, P316, DOI 10.1016/S0196-0709(98)90005-9 STEINMAN.EP, 1970, ARCHIV OTOLARYNGOL, V91, P171 Zuber M, 1999, NEUROLOGY, V53, P1886 NR 10 TC 30 Z9 31 PU AMER SOC NEURORADIOLOGY PI OAK BROOK PA 2210 MIDWEST RD, OAK BROOK, IL 60521 USA SN 0195-6108 J9 AM J NEURORADIOL JI Am. J. Neuroradiol. PD JAN PY 2007 VL 28 IS 1 BP 143 EP 145 PG 3 WC Clinical Neurology; Neuroimaging; Radiology, Nuclear Medicine & Medical Imaging SC Neurosciences & Neurology; Radiology, Nuclear Medicine & Medical Imaging GA 127PK UT WOS:000243598600033 PM 17213444 ER PT J AU Sanchez, TG Lima, AD Brandao, AL Lorenzi, MC Bento, RF AF Sanchez, Tanit Ganz Lima, Adriana da Silva Brandao, Ana Laura Lorenzi, Maria Cecilia Bento, Ricardo Ferreira TI Somatic modulation of tinnitus: Test reliability and results after repetitive muscle contraction training SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE auditory connection; rehabilitation; somatic modulation; somatosensory system; tinnitus ID COCHLEAR NUCLEUS; AUDITORY-PERCEPTION; CAT AB Objectives: We sought to study the reliability of tinnitus modulation by muscle contractions and to observe the effect of their prolonged repetition. Methods: Thirty-eight patients with tinnitus underwent 9 maneuvers of muscle contractions in test and retest situations. After a 2-month training period of repeating the maneuvers, tinnitus modulation and daily perception were evaluated. Results: There was no difference between the occurrence of tinnitus modulation in test (57.9%) and retest (63.2%) situations. After 2 months, the occurrence of modulation during the maneuvers was similar (55.3%), but a new pattern showed an increase in tinnitus improvement and a decrease in tinnitus worsening. The daily perception of tinnitus was unchanged. Conclusions: Maneuvers of head and neck muscle contractions evoked tinnitus modulation in a frequent and reliable manner. Also, the repetition of such maneuvers for 2 months altered the pattern of modulation. C1 Univ Sao Paulo, Sch Med, Dept Otolaryngol, Sao Paulo, Brazil. RP Sanchez, TG (reprint author), Rua Tenente Negrao,140 CJ 91, BR-04530030 Sao Paulo, Brazil. CR Abel MD, 2004, CRANIO, V22, P181 Cacace AT, 2003, HEARING RES, V175, P112, DOI 10.1016/S0378-5955(02)00717-7 HOTTA T, 1963, EXP NEUROL, V8, P1, DOI 10.1016/0014-4886(63)90003-7 JASTREBOFF PJ, 1990, NEUROSCI RES, V8, P221, DOI 10.1016/0168-0102(90)90031-9 Jastreboff P J, 2000, J Am Acad Audiol, V11, P162 JASTREBOFF PJ, 2002, BALLENGERS OTORHINOL, P456 KANDEL ER, 2000, PRINCIPLES NEURAL SC, P18 Levine RA, 1999, AM J OTOLARYNG, V20, P351, DOI 10.1016/S0196-0709(99)90074-1 Levine RA, 1999, P 6 INT TINN SEM CAM, P193 Lockwood AH, 1998, NEUROLOGY, V50, P114 MOLLER AR, 1992, LARYNGOSCOPE, V102, P187 Sanchez T, 1997, ARQ FUND OTORRINOLAR, V1, P2 Sanchez TG, 1997, REV BRAS OTORRINOLAR, V63, P229 Sanchez TG, 2002, AUDIOL NEURO-OTOL, V7, P370, DOI 10.1159/000066155 Shore SE, 2003, NEUROSCIENCE, V119, P1085, DOI 10.1016/S0306-4522(03)00207-0 THOMPSON RF, 1963, J NEUROPHYSIOL, V26, P365 Wright DD, 1996, J COMP NEUROL, V365, P159, DOI 10.1002/(SICI)1096-9861(19960129)365:1<159::AID-CNE12>3.0.CO;2-L NR 17 TC 17 Z9 20 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD JAN PY 2007 VL 116 IS 1 BP 30 EP 35 PG 6 WC Otorhinolaryngology SC Otorhinolaryngology GA 130ET UT WOS:000243783100006 PM 17305275 ER PT J AU Czyewski, A Skarzynski, H AF Czyewski, Andrzej Skarzynski, Henryk TI Multimedia applications for the hearing impaired SO ARCHIVES OF ACOUSTICS LA English DT Article DE hearing screening; tinnitus; hearing aids fitting ID AUDIO AB Hearing impairment is one of the fastest growing diseases of modern society. Therefore it is very important to develop new methods for diagnosis and therapy of hearing disorders. Some of them were introduced to practice as a result of a co-operation between institutions mentioned in the header. The system for mass-scale hearing screening is one of multimedia programs for testing communication senses introduced by the authors. The further developments include among others an application of dithering theory to practical solutions for tinnitus patients and a method of fitting hearing aids employing soft computing. The implemented hearing diagnostic & therapy applications and systems with their underlying concepts are reviewed in this paper. C1 [Czyewski, Andrzej] Gdansk Univ Technol, Multimedia Syst Dept, PL-80952 Gdansk, Poland. [Skarzynski, Henryk] Inst Physiol & Pathol Hearing, PL-01942 Warsaw, Poland. RP Czyewski, A (reprint author), Gdansk Univ Technol, Multimedia Syst Dept, Narutowicza 11-12, PL-80952 Gdansk, Poland. EM ac@pg.gda.pl CR ALLEN JB, 1990, J ACOUST SOC AM, V88, P745, DOI 10.1121/1.399778 Czyzewski A, 2006, TINNITUS DIAGNOSIS T, P277 CZYZEWSKI A, 2002, INT J INTELL SYST, P277 CZYZEWSKI A, 2006, INFORM TECHNOLOGY SO, P225, DOI 10.1007/1-84628-141-5_10 CZYZEWSKI A, 2005, SERIES ADV SOFT COMP, V12, P397 CZYZEWSKI A., 2002, COMPUTER TECHNOLOGY CZYZEWSKI A., 2006, 120 AUD ENG SOC CONV CZYZEWSKI A, 2001, DIGITAL SOUND LIPSHITZ SP, 1992, J AUDIO ENG SOC, V40, P355 MCNALLY GW, 1984, J AUDIO ENG SOC, V32, P316 SKARZYNSKI H, 1998, TINNITUS HYPERSENSIT Skinner M. W., 1988, HEARING AID EVALUATI STIKVOORT EF, 1986, J AUDIO ENG SOC, V34, P3 SUCHOMSKI P, 2005, THESIS GDANSK U TECH NR 14 TC 0 Z9 0 PU POLISH ACAD SCIENCES INST FUNDAMENTAL TECHNOLOGICAL RESEARCH PI WARSAW PA PAWINSKIEGO 5B, 02-106 WARSAW, POLAND SN 0137-5075 J9 ARCH ACOUST JI Arch. Acoust. PY 2007 VL 32 IS 3 BP 491 EP 504 PG 14 WC Acoustics SC Acoustics GA 293LZ UT WOS:000255338100005 ER PT J AU Job, A Raynal, M Kossowski, M AF Job, Agnes Raynal, Marc Kossowski, Michel TI Susceptibility to tinnitus revealed at 2 kHz range by bilateral lower DPOAEs in normal hearing subjects with noise exposure SO AUDIOLOGY AND NEURO-OTOLOGY LA English DT Article DE susceptibility to tinnitus, pilots; aircraft noise exposure; distortion products otoacoustic emissions; DP-grams; DPOAE-grams; hearing levels ID ACUTE ACOUSTIC TRAUMA; OTOACOUSTIC EMISSIONS; REORGANIZATION; HUMANS; SYSTEM AB We investigated potential markers of susceptibility to tinnitus in a group of normal hearing young pilots aged 25-35 years and with 8 8 5 years of aircraft noise exposure. 316 pilots were interviewed about their tinnitus status and were tested for hearing thresholds (audiograms) and distortion products otoacoustic emissions (DPOAE-grams). There was no subject with permanent tinnitus. 23% reported having occasionally perceived tinnitus after flight missions and 77% reported never having experienced tinnitus after flight missions. General discomfort in the ears to noise was higher in the occasional tinnitus group (15 vs. 6%). The major finding was that difference of susceptibility to tinnitus in normal hearing subjects exposed to noise on a daily basis seemed to be clearly related to lower DPOAEs, bilaterally, in the 1500- to 2800-kHz range. However, no difference could be observed between groups on audiograms at the 2-kHz frequency range. This study provided evidence of outer hair cell dysfunctions in normal hearing subjects exposed to noise and susceptible to tinnitus. Hypersensitivity to noise and decreased DPOAEs in a non-noise-specific frequency range support the idea of another alteration mechanism than noise itself. This point was discussed in the light of recent publications. Copyright (C) 2007 S. Karger AG, Basel. C1 CRSSA, FR-38702 La Tronche, France. Hop Instruct Armees Percy, Serv ORL, Clamart, France. RP Job, A (reprint author), CRSSA, 24 Ave Maquis Gresivaudan,POB 87, FR-38702 La Tronche, France. 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Neuro-Otol. PY 2007 VL 12 IS 3 BP 137 EP 144 DI 10.1159/000099025 PG 8 WC Audiology & Speech-Language Pathology; Neurosciences; Otorhinolaryngology SC Audiology & Speech-Language Pathology; Neurosciences & Neurology; Otorhinolaryngology GA 149GX UT WOS:000245136300001 PM 17259699 ER PT J AU Hiller, W Goebel, G AF Hiller, Wolfgang Goebel, Gerhard TI When tinnitus loudness and annoyance are discrepant: Audiological characteristics and psychological profile SO AUDIOLOGY AND NEURO-OTOLOGY LA English DT Article DE tinnitus; tinnitus loudness; annoyance rating; psychological profile; hyperacusis ID PSYCHIATRIC-DISORDERS; SEVERITY; DISTRESS; RELIABILITY; ASSOCIATION; POPULATION; VARIABLES AB This study evaluates sociodemographic and clinical characteristics of patients reporting discrepant levels of tinnitus loudness and annoyance. 4958 subjects recruited from a national tinnitus association completed a comprehensive screening questionnaire including Klockhoff and Lindblom's loudness grading system and the psychometric Mini-TQ ( Tinnitus Questionnaire). There was a moderate correlation of 0.45 between loudness and annoyance. Of the subjects reporting very loud tinnitus, about one third had only mild or moderate annoyance scores. They were not different from those with high annoyance regarding age, gender and tinnitus duration, but annoyance was increased when subjects had additional hearing loss (OR = 1.71), vertigo/dizziness (OR = 1.94) or hyperacusis (OR = 4.96). Another significant predictor was history of neurological disease (OR = 3.16). Subjects reported low annoyance despite high loudness more often if not feeling low/depressed and not considering themselves as victims of their noises. A specific psychological profile was found to characterize annoyed tinnitus sufferers. Permanent awareness of the noises, decreased ability to ignore them and concentration difficulties were reported frequently even when overall annoyance scores were comparatively low. It is concluded that the coexistence of tinnitus with hearing loss, vertigo/dizziness and hyperacusis as complicating otological conditions seems to be of clinical relevance for the prediction of high annoyance levels. Tinnitus loudness and annoyance are not necessarily congruent and should be assessed separately. Copyright (c) 2007 S. Karger AG, Basel. C1 Univ Mainz, Dept Clin Physiol, D-55099 Mainz, Germany. Roseneck Ctr Behav Med, Prien Am Chiemsee, Germany. RP Hiller, W (reprint author), Univ Mainz, Dept Clin Physiol, Staudingerweg 9, D-55099 Mainz, Germany. EM hiller@mail.uni-mainz.de CR Andersson G, 1999, CLIN OTOLARYNGOL, V24, P404, DOI 10.1046/j.1365-2273.1999.00278.x Andersson G, 2004, NORD J PSYCHIAT, V58, P287, DOI 10.1080/08039480410005792 Andersson G, 2003, AURIS NASUS LARYNX, V30, P129, DOI 10.1016/S0385-8146(03)00008-7 Dauman R., 1992, P 4 INT TINN SEM BOR, P225 Davis A, 1995, HEARING ADULTS El Refaie A, 2004, INT J AUDIOL, V43, P410 ERLANDSSON SI, 1992, AUDIOLOGY, V31, P168 Erlandsson SI, 2001, NOISE HEALTH, V3, P39 Folmer RL, 1999, OTOLARYNG HEAD NECK, V121, P48, DOI 10.1016/S0194-5998(99)70123-3 Folmer Robert L, 2004, Ear Nose Throat J, V83, P107 Folmer RL, 2001, OTOLARYNG HEAD NECK, V124, P394, DOI 10.1067/mhn.2001.114673 FOWLER E P, 1955, Ann Otol Rhinol Laryngol, V64, P29 FOWLER EP, 1948, LARYNGOSCOPE, V58, P145 GOEBEL G, 2001, STRUKTURIERTE TINNIT HALFORD JBS, 1991, J LARYNGOL OTOL, V105, P89, DOI 10.1017/S0022215100115038 HALLAM RS, 1988, BRIT J CLIN PSYCHOL, V27, P213 Hallam RS, 2004, INT J AUDIOL, V43, P218, DOI 10.1080/14992020400050030 Hallam RS, 1984, CONTRIBUTIONS MED PS, V3, P31 Hallam RS., 1996, MANUAL TINNITUS QUES HALLAM RS, 1985, ACTA OTO-LARYNGOL, V99, P501 Henry J A, 2000, J Am Acad Audiol, V11, P138 HILLER W, 1994, BRIT J CLIN PSYCHOL, V33, P231 Hiller W, 1999, INT J BEHAV MED, V6, P312, DOI 10.1207/s15327558ijbm0604_2 HILLER W, 1992, J PSYCHOSOM RES, V36, P337, DOI 10.1016/0022-3999(92)90070-I Hiller W, 2005, BEHAV RES THER, V43, P595, DOI 10.1016/j.brat.2004.03.012 Hiller W, 2004, INT J AUDIOL, V43, P600 Holgers KM, 2000, AUDIOLOGY, V39, P284 JASTREBOFF PJ, 1990, NEUROSCI RES, V8, P221, DOI 10.1016/0168-0102(90)90031-9 Kaldo-Sandström Viktor, 2004, Am J Audiol, V13, P185, DOI 10.1044/1059-0889(2004/023) Klockhoff I, 1967, Acta Otolaryngol, V63, P347, DOI 10.3109/00016486709128769 Marciano E, 2003, INT J AUDIOL, V42, P4, DOI 10.3109/14992020309056079 McCombe A, 2001, CLIN OTOLARYNGOL, V26, P388, DOI 10.1046/j.1365-2273.2001.00490.x MEIKLE MB, 1984, OTOLARYNG HEAD NECK, V92, P689 Nelson Jeffrey J, 2004, Ear Nose Throat J, V83, P472 Newman C W, 1997, J Am Acad Audiol, V8, P143 NEWMAN CW, 1994, AUDIOLOGY, V33, P47 Pilgramm M, 1999, P 6 INT TINN SEM CAM, P64 Reynolds P, 2004, CLIN OTOLARYNGOL, V29, P628, DOI 10.1111/j.1365-2273.2004.00879.x SCOTT B, 1990, British Journal of Audiology, V24, P51, DOI 10.3109/03005369009077842 Stobik C, 2005, INT J AUDIOL, V44, P370, DOI 10.1080/14992020500147557 STOUFFER JL, 1990, J SPEECH HEAR DISORD, V55, P439 STOUFFER JL, 1991, AM J OTOL, V12, P188 TYLER RS, 1983, J SPEECH HEAR RES, V26, P59 Tyler R S, 1983, Br J Audiol, V17, P101, DOI 10.3109/03005368309078916 Zachriat Claudia, 2004, Cognitive Behaviour Therapy, V33, P187, DOI 10.1080/16506070410029568 Zoger S, 2001, AUDIOLOGY, V40, P133 NR 46 TC 30 Z9 30 PU KARGER PI BASEL PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND SN 1420-3030 J9 AUDIOL NEURO-OTOL JI Audiol. Neuro-Otol. PY 2007 VL 12 IS 6 BP 391 EP 400 DI 10.1159/000106482 PG 10 WC Audiology & Speech-Language Pathology; Neurosciences; Otorhinolaryngology SC Audiology & Speech-Language Pathology; Neurosciences & Neurology; Otorhinolaryngology GA 211PT UT WOS:000249536500005 PM 17664870 ER PT J AU Sainz, M Garcia-Valdecasas, J Garofano, M Ballesteros, JM AF Sainz, M. Garcia-Valdecasas, J. Garofano, M. Ballesteros, J. M. TI Otosclerosis: Mid-term results of cochlear implantation SO AUDIOLOGY AND NEURO-OTOLOGY LA English DT Article DE otosclerosis; retrofenestral otosclerosis; cochlear; otosclerosis; cochlear implant; fitting; hearing skills AB Introduction: Constant histological changes in otosclerosis lead to progressive hearing loss which may end up in a profound hearing loss and then be treated by means of cochlear implants. These progressive changes could be followed by changes in cochlear implants fitting and speech discrimination results over the years. Objectives: The aim of the study is to correlate the progressive histological changes to the cochlear implant clinical outcomes (fitting and speech discrimination results). Also main complications (facial nerve stimulation and difficulties at insertion) and new complications will be discussed. Design: A 5-year prospective case-control study was performed in order to compare cochlear implant results in otosclerosis patients to those in a matched-pair control group. Materials and Methods: Fifteen otosclerosis patients were followed throughout the study. Preoperatively temporal bone high-resolution computed tomography, electrically evoked auditory brainstem responses and speech discrimination tests were performed in order to select the patients to be implanted. Results: Not only difficulties with electrode guide insertion were reported, but also difficulties with fitting over the years, due to increasing difficulties to spread the electrical stimuli, which provokes increasing thresholds, maximum comfort levels and charges needed to stimulate hearing cells in basal and medial turn electrodes (p < 0.05), which required deactivating some basal and medial turn electrodes in order to improve cochlear implant effectiveness. The results demonstrated no statistical differences in speech discrimination in otosclerosis patients compared to the control group (p > 0.05). Several complications were reported: facial nerve stimulation (7.14%) and sudden episodes of tinnitus and headaches (14.28%). Conclusions: Although progressive histological changes in otosclerosis lead to increasing thresholds, maximum comfort levels and charges needed to stimulate hearing cells, speech discrimination results support the cochlear implantation in otosclerosis. Copyright (c) 2007 S. Karger AG, Basel. C1 Hosp Clin S Cecilio, Granada, Spain. RP Sainz, M (reprint author), C Nueva Virgen 9,Portal 3,2D, ES-18005 Granada, Spain. EM juanvaldecasas@eresmas.com CR Arnold W, 1999, LARYNGO RHINO OTOL, V78, P20, DOI 10.1055/s-2007-996822 Bigelow DC, 1998, AM J OTOL, V19, P163 Doherty JK, 2004, OTOL NEUROTOL, V25, P457, DOI 10.1097/00129492-200407000-00010 Jaekel K, 2004, LARYNGO RHINO OTOL, V83, P457, DOI 10.1055/s-2004-814456 Mosnier I, 2007, ADV OTO-RHINO-LARYNG, V65, P323, DOI 10.1159/000098854 Niedermeyer HP, 2002, ORL J OTO-RHINO-LARY, V64, P114, DOI 10.1159/000057789 QUARANTA N, 2004, ACTA OTO-LARYNGOL, V552, P68 Quaranta N, 2005, OTOL NEUROTOL, V26, P983, DOI 10.1097/01.mao.0000185047.77017.31 Ramsden R, 2007, ADV OTO-RHINO-LARYNG, V65, P328, DOI 10.1159/000098855 Stimmer H, 2002, ORL J OTO-RHINO-LARY, V64, P451, DOI 10.1159/000067565 NR 10 TC 5 Z9 5 PU KARGER PI BASEL PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND SN 1420-3030 J9 AUDIOL NEURO-OTOL JI Audiol. Neuro-Otol. PY 2007 VL 12 IS 6 BP 401 EP 406 DI 10.1159/000106773 PG 6 WC Audiology & Speech-Language Pathology; Neurosciences; Otorhinolaryngology SC Audiology & Speech-Language Pathology; Neurosciences & Neurology; Otorhinolaryngology GA 211PT UT WOS:000249536500006 PM 17675831 ER PT J AU Van de Heyning, P Lefebvre, P De Ridder, D AF Van de Heyning, P. Lefebvre, Ph. De Ridder, D. TI Tinnitus: from cochlear to cortical - Foreword SO B-ENT LA English DT Editorial Material DE Tinnitus; translational research; neuroscience ID AUDITORY PATHWAY; STIMULATION; PERCEPTION; CORTEX AB Tinnitus: from Cochlear to Cortical. Tinnitus is presented in view of translational research from research to clinical application. C1 [Van de Heyning, P.; De Ridder, D.] Univ Antwerp, Univ Antwerp Hosp, Univ Dept Otorhinolaryngol & Neurosurg, BRAIN, Antwerp, Belgium. [Lefebvre, Ph.] Univ Liege, Dept Otorhinolaryngol, Liege, Belgium. RP Van de Heyning, P (reprint author), UZA, Univ Dept Otorhinolaryngol & Head & Neck Surg, Wilrijk Str 10, B-2650 Antwerp, Belgium. EM paul.van.de.heyning@uza.be CR De Ridder Dirk, 2007, Int J Med Sci, V4, P242 De Ridder D, 2007, PROG BRAIN RES, V166, P55, DOI 10.1016/S0079-6123(07)66005-1 De Ridder D, 2006, ORL J OTO-RHINO-LARY, V68, P48, DOI 10.1159/000090491 JASTREBOFF PJ, 1993, BRIT J AUDIOL, V27, P7, DOI 10.3109/03005369309077884 JASTREBOFF PJ, 1990, NEUROSCI RES, V8, P221, DOI 10.1016/0168-0102(90)90031-9 Langguth B, 2003, NEUROREPORT, V14, P977, DOI 10.1097/01.wnr.0000068897.39523.41 Langguth B, 2007, PROG BRAIN RES, V166, P525, DOI 10.1016/S0079-6123(07)66050-6 Llinas R, 1998, PHILOS T ROY SOC B, V353, P1841, DOI 10.1098/rstb.1998.0336 Llinas RR, 1999, P NATL ACAD SCI USA, V96, P15222, DOI 10.1073/pnas.96.26.15222 Lockwood AH, 2002, NEW ENGL J MED, V347, P904, DOI 10.1056/NEJMra013395 Moller A R, 2000, J Am Acad Audiol, V11, P115 MOLLER AR, 1992, LARYNGOSCOPE, V102, P1165 Muhlnickel W, 1998, P NATL ACAD SCI USA, V95, P10340, DOI 10.1073/pnas.95.17.10340 NORENA A, 2005, J NEUROSCI, V19, P699 PASCUALMARQUI RD, 1994, INT J PSYCHOPHYSIOL, V18, P49, DOI 10.1016/0167-8760(84)90014-X Plewnia C, 2003, ANN NEUROL, V53, P263, DOI 10.1002/ana.10468 Smits M, 2007, NEURORADIOLOGY, V49, P669, DOI 10.1007/s00234-007-0231-3 Weisz N, 2007, J NEUROSCI, V27, P1479, DOI 10.1523/JNEUROSCI.3711-06.2007 NR 18 TC 15 Z9 15 PU ROYAL BELGIAN SOC EAR, NOSE, THROAT, HEAD & NECK SURGERY PI LEUVEN PA PO BOX 1248, LEUVEN, 00000, BELGIUM SN 0001-6497 J9 B-ENT JI B-ENT PY 2007 SU 7 BP 1 EP 2 PG 2 WC Otorhinolaryngology SC Otorhinolaryngology GA 240SY UT WOS:000251608900001 ER PT J AU Van de Heyning, P Meeus, O Blaivie, C Vermeire, K Boudewyns, A De Ridder, D AF Van de Heyning, P. Meeus, O. Blaivie, C. Vermeire, K. Boudewyns, A. De Ridder, D. TI Tinnitus: a multidisciplinary clinical approach SO B-ENT LA English DT Article DE Tinnitus; diagnosis; clinical approach ID TRANSCRANIAL MAGNETIC STIMULATION; HANDICAP INVENTORY; AUDITORY-CORTEX; QUESTIONNAIRE; SUPPRESSION; REORGANIZATION; COMPRESSION; HYPERACUSIS; COMORBIDITY; PLASTICITY AB Tinnitus: a multidisciplinary clinical approach. This article provides a clinical step-by-step approach for assessing a patient with tinnitus as primary complaint. The medical diagnosis of the disease provoking the tinnitus has to be made first in a comprehensive evaluation, including imaging. The psycho-acoustic characteristics and the influence on health-related quality of life is a compulsory complementary assessment to establish a complete picture of the patient. C1 [Van de Heyning, P.; Meeus, O.; Blaivie, C.; Vermeire, K.; Boudewyns, A.] Univ Dept Otorhinolaryngol & Head & Neck Surg, Antwerp, Belgium. [De Ridder, D.] Univ Antwerp, Fac Med, Antwerp Univ Hosp, Neurosurg Univ Multidisciplinary Tinnitus Ctr Ant, Antwerp, Belgium. RP Van de Heyning, P (reprint author), UZA, Univ Dept Otolaryngol & Head & Neck Surg, Wilrijk Str 10, B-2650 Antwerp, Belgium. 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Blaivie, C. Van de Heyning, P. TI Validation of the Dutch and the French version of the Tinnitus questionnaire SO B-ENT LA English DT Article DE Tinnitus; questionnaire; translation; psychometric; validation ID HANDICAP INVENTORY AB Validation of the Dutch and the French version of the Tinnitus Questionnaire. Objectives: To validate the Dutch and the French version of the Tinnitus Questionnaire and characterise the subscales. The original Tinnitus Questionnaire has already proven to be a usable measurement tool to discriminate complaining from non-complaining tinnitus patients and it provides differentiation into 5 dimensions. Methods: The English version of the TQ was used. The Dutch and the French version were obtained by the process of translation and back-translation. The TQ was assessed in 167 patients whose mother tongue was Dutch and who presented at the ENT department of the Antwerp University Hospital. Internal consistency was evaluated using Cronbach's alpha coefficient. Factor analysis with Varimax oblique rotation was compared to the results from previous psychometric analysis of the original TQ. Results: The internal consistency of the Dutch version of the TQ proved to be very high, with a Cronbach's alpha value of 0.95. Independent factor analysis identified the five subscales in accordance with the Hiller and Goebel's findings: emotional and cognitive distress, intrusiveness, auditory perceptual difficulties, sleep disturbances and somatic complaints. Conclusion: The Dutch and the French translation of the TQ are included here. The psychometric characters of the Dutch questionnaire are similar to the original English questionnaire. This questionnaire provides appropriate disease-specific health-related quality-of-life outcome measures in tinnitus patients. In addition to the TQ, we advise the incorporation of three equal-appearing interval scales in all tinnitus anamnesis and follow-up. C1 [Meeus, O.; Blaivie, C.; Van de Heyning, P.] Univ Antwerp, Antwerp Univ Hosp UZA, Univ Dept Otorhinolaryngol & Head & Neck Surg, Antwerp, Belgium. RP Meeus, O (reprint author), Antwerp Univ Hosp, UZA, Wilrijk Str 10, B-2650 Edegem, Belgium. EM olivier.meeus@uza.be CR Baguley DM, 2000, J LARYNGOL OTOL, V114, P840 CRONBACH LJ, 1951, PSYCHOMETRIKA, V16, P297 GOEBEL G, 1994, HNO, V42, P166 HALLAM RS, 1988, BRIT J CLIN PSYCHOL, V27, P213 Heller AJ, 2003, OTOLARYNG CLIN N AM, V36, P239, DOI 10.1016/S0030-6665(02)00160-3 HILLER W, 1994, BRIT J CLIN PSYCHOL, V33, P231 HILLER W, 1992, J PSYCHOSOM RES, V36, P337, DOI 10.1016/0022-3999(92)90070-I Langguth B, 2007, PROG BRAIN RES, V166, P525, DOI 10.1016/S0079-6123(07)66050-6 Meikle MB, 1995, 18 MIDW RES M ASS RE, P167 Newman CW, 1996, ARCH OTOLARYNGOL, V122, P143 NR 10 TC 14 Z9 14 PU ROYAL BELGIAN SOC EAR, NOSE, THROAT, HEAD & NECK SURGERY PI LEUVEN PA PO BOX 1248, LEUVEN, 00000, BELGIUM SN 0001-6497 J9 B-ENT JI B-ENT PY 2007 SU 7 BP 11 EP 17 PG 7 WC Otorhinolaryngology SC Otorhinolaryngology GA 240SY UT WOS:000251608900003 ER PT J AU Van de Heyning, PH De Valck, CFJ Boudewyns, A Cammaert, T Casteleyn, S Deggouj, N Gordts, F Forton, G Lefebvre, P Robillard, T AF Van de Heyning, P. H. De Valck, C. F. J. Boudewyns, A. Cammaert, T. Casteleyn, S. Deggouj, N. Gordts, F. Forton, G. Lefebvre, Ph. Robillard, Th. TI Meniere's disease SO B-ENT LA English DT Article DE guidelines; Meniere's disease; inner ear; treatment ID QUALITY-OF-LIFE; ENDOLYMPHATIC HYDROPS; SYMPTOMS; SURGERY AB Meniere's disease. Meniere's disease is an idiopathic inner ear disorder characterized by endolymphatic hydrops (ELH), vertigo attacks, sensorineural hearing loss, tinnitus and pressure sensation in the affected ear. The disorder has to be differentiated from known causes of ELH and from other disorders provoking similar symptoms. Meniere's disease can seriously affect quality of life, and medical support is often necessary on a life long basis. The treatment modalities are counselling, preventive measures and life style adaptation, drug therapy, tinnitus coping, provision of hearing devices, and sometimes surgery. We review the indications for these modalities, and the evidence level of their beneficial effect. C1 Univ Antwerp, Univ Antwerp Hosp, B-2020 Antwerp, Belgium. St Lucas Gen Hosp, Dept Otorhinolaryngol, Ghent, Belgium. St Luc Univ Hosp, Dept Otorhinolaryngol, Brussels, Belgium. Univ Hosp Free Univ, Dept Otorhinolaryngol, Brussels, Belgium. Heilig Hart Gen Hosp, Dept Otorhinolaryngol, Roeselare, Belgium. CHU Sart Tilman, Dept Otorhinolaryngol, B-4000 Liege, Belgium. Clin St Elizabeth, Dept Otorhinolaryngol, Namur, Belgium. RP Van de Heyning, PH (reprint author), Univ Antwerp, Univ Antwerp Hosp, B-2020 Antwerp, Belgium. 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TI Cochlear NMDA receptor blockade prevents salicylate-induced tinnitus SO B-ENT LA English DT Article DE salicylate; tinnitus; NMDA receptor; arachidonic acid; cyclooxygenase; cochlea ID GUINEA-PIG; GLUTAMATE RECEPTORS; ANIMAL-MODEL; AMPA; OTOTOXICITY; SUBUNITS AB Cochlear NMDA receptor blockade prevents salicylate-induced tinnitus. Large doses of aspirin produce reversible hearing loss and tinnitus. These effects have been attributed to the salicylate ion, the active component of aspirin. Salicylate acts as a competitive antagonist at the anion-binding site of prestin, the motor protein of sensory outer hair cells. This provides an explanation for the hearing loss induced by aspirin. However, the molecular mechanism of salicyl ate-induced tinnitus remains obscure. One physiological explanation is that salicylate ototoxicity is likely to originate in an alteration to arachidonic acid metabolism. Arachidonic acid potentiates NMDA receptor currents. We therefore tested the involvement of cochlear NMDA receptors in the occurrence of tinnitus. Tinnitus was assessed with a behavioural test based on an active avoidance paradigm. Results showed that the tinnitus induced by salicylate may be suppressed by the introduction of NMDA antagonists into the cochlear fluids. To determine if the activation of NMDA receptors was linked to cyclooxygenase inhibition, we investigated the effect of mefenamate (a potent cyclooxygenase inhibitor). Since NMDA antagonists also blocked mefenamate-induced tinnitus, we suggest that salicylate-induced tinnitus is mediated by cochlear NMDA receptors through the inhibition of cyclooxygenase activity. Target cochlear NMDA receptors may therefore present a therapeutic strategy for the treatment of tinnitus. C1 [Puel, J. -L.] Univ Montpellier 1, INSERM U 583, Physiopathol Therap Deficits Sens Moteurs, CHU St Eloi, F-34095 Montpellier, France. RP Puel, JL (reprint author), Univ Montpellier 1, INSERM U 583, Physiopathol Therap Deficits Sens Moteurs, CHU St Eloi, F-34095 Montpellier, France. 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Robillard, Th. Gilain, C. Thill, M-P. Boudewyns, A. Van Cauwenberge, P. TI Tinnitus SO B-ENT LA English DT Article DE guidelines; tinnitus; treatment ID QUESTIONNAIRE; VALIDATION AB Tinnitus. This article is based on a review of the literature and the experience of some experts. Its goal is to present an overview of the physiopathology of tinnitus and perspectives of treatment based on recent publications. Tinnitus is;a problem of society, affecting about 10% of the population. The causes of tinnitus are extremely diverse. Objective tinnitus is generally pulsatile and from arterial or venous origin; subjective tinnitus can be generated at any level of the auditory pathways. Approach to tinnitus includes qualification through anamnesis and specialized questionnaires, and thorough audiological characterization. Sometimes, imaging is indicated as it can reveal the cause of the tinnitus in case of a vascular abnormality or a retro-cochlear tumour. Among the various medications prescribed for tinnitus, only anti-depressants proved to be efficient when secondary depression is present. Hearing aids are useful for hearing impaired patients but the efficiency of tinnitus maskers is not proved. Tinnitus Retraining Therapy is very promising but results must be confirmed by future studies. Studies about neurostimulation are in progress. In the future, better understanding of the physiopathology of tinnitus will lead to new treatments. C1 Clin St Elizabeth, ENT Dept, Namur, Belgium. Clin Univ Mt Godinne, ENT Dept, Yvoir, Belgium. CHU St Pierre, ENT Dept, Brussels, Belgium. UIA, Univ Hosp, ENT Dept, Antwerp, Belgium. Univ Ghent, Dept Otorhinolaryngol, B-9000 Ghent, Belgium. RP Englebert, A (reprint author), Clin St Elizabeth, ENT Dept, Namur, Belgium. EM ann.englebert@skynet.be CR Bauer Carol A, 2004, Curr Opin Otolaryngol Head Neck Surg, V12, P413, DOI 10.1097/01.moo.0000134443.29853.09 Brookes GB, 1996, AM J OTOL, V17, P569 Dobie RA, 1999, LARYNGOSCOPE, V109, P1202, DOI 10.1097/00005537-199908000-00004 Eggermont JJ, 2004, TRENDS NEUROSCI, V27, P676, DOI 10.1016/j.tins.2004.08.010 FRACHET B, 2004, MONOGRAPHIE AMPLIFON, P37 GLUCKMAN JL, 1998, RENEWAL CERTIFICATIO, P159 HAZELL J, 1998, 18 EUROPEAN INSTRUCT Heller AJ, 2003, OTOLARYNG CLIN N AM, V36, P239, DOI 10.1016/S0030-6665(02)00160-3 Henry James A, 2004, J Am Acad Audiol, V15, P585, DOI 10.3766/jaaa.15.8.6 Jannetta P J, 1997, Clin Neurosurg, V44, P331 Johnsrude IS, 2002, AUDIOL NEURO-OTOL, V7, P251, DOI 10.1159/000064446 Kay N J, 1981, Br J Audiol, V15, P123, DOI 10.3109/03005368109081425 Lechtenberg R, 1984, J LARYNGOL OTOL S, V9, p271e6 Lockwood AH, 2002, NEW ENGL J MED, V347, P904, DOI 10.1056/NEJMra013395 Meric C, 2000, J SPEECH LANG HEAR R, V43, P184 Meric C, 1997, J OTOLARYNGOL, V26, P167 MEYER B, 2001, RAPPORT SOC FRANCAIS, P55 Moller AR, 2003, OTOLARYNG CLIN N AM, V36, P249, DOI 10.1016/S003-6665(02)00170-6 Muhlau M, 2006, CEREB CORTEX, V16, P1283, DOI 10.1093/cercor/bhj070 Muhlnickel W, 1998, P NATL ACAD SCI USA, V95, P10340, DOI 10.1073/pnas.95.17.10340 MURAI K, 1992, AM J OTOL, V13, P454 Newman CW, 1996, ARCH OTOLARYNGOL, V122, P143 Park JB, 2000, ARCH OTOLARYNGOL, V126, P489 Schwaber MK, 2003, OTOLARYNG CLIN N AM, V36, P287, DOI 10.1016/S0030-6665(02)00161-5 Sismanis A, 2003, OTOLARYNG CLIN N AM, V36, P389, DOI 10.1016/S0030-6665(02)00169-X Vernon JA, 2003, OTOLARYNG CLIN N AM, V36, P293, DOI 10.1016/S0030-6665(02)00162-7 Vernon JA, 2003, OTOLARYNG CLIN N AM, V36, P307, DOI 10.1016/S0030-6665(02)00163-9 Vesterager V, 1997, BRIT MED J, V314, P728 WADDELL A, 2003, CLIN EVIDENCE, V9, P598 ZIGMOND AS, 1983, ACTA PSYCHIAT SCAND, V67, P361, DOI 10.1111/j.1600-0447.1983.tb09716.x NR 30 TC 0 Z9 0 PU ROYAL BELGIAN SOC EAR, NOSE, THROAT, HEAD & NECK SURGERY PI LEUVEN PA PO BOX 1248, LEUVEN, 00000, BELGIUM SN 0001-6497 J9 B-ENT JI B-ENT PY 2007 SU 6 BP 21 EP 32 PG 12 WC Otorhinolaryngology SC Otorhinolaryngology GA 216HS UT WOS:000249869700004 ER PT J AU Ursick, J Staecker, H AF Ursick, J. Staecker, H. TI An overview of animal models of tinnitus SO B-ENT LA English DT Article DE spontaneous activity; dorsal cochlear nucleus; inferior colliculus; tinnitus ID DORSAL COCHLEAR NUCLEUS; INFERIOR COLLICULUS; RATS; EXPOSURE; SOUND AB An overview of animal models of tinnitus. Tinnitus, or the phantom perception of sound, is one of the great unsolved problems of otology. It is present in all patients with hearing loss and, in approximately 5-10% of individuals, it has a significant impact on quality of life. Progress in the treatment of tinnitus has been limited by a lack of animal models that can be used to study the neurophysiology of tinnitus and to examine prospective treatment. In the last ten years, several physiological and behavioural animal models of tinnitus have been developed that have significantly increased our understanding. The next ten years will see the application of these models to drug development and electrical stimulus approaches to curing tinnitus. C1 [Ursick, J.; Staecker, H.] Univ Kansas, Sch Med, Dept Otolaryngol Head & Neck Surg, Kansas City, KS 66160 USA. RP Staecker, H (reprint author), Univ Kansas, Sch Med, Dept Otolaryngol Head & Neck Surg, 3901 Rainbow Blvd, Kansas City, KS 66160 USA. EM Hstaecker@kumc.edu CR Bauer Carol A, 2004, Curr Opin Otolaryngol Head Neck Surg, V12, P413, DOI 10.1097/01.moo.0000134443.29853.09 Brozoski TJ, 2007, HEARING RES, V228, P168, DOI 10.1016/j.heares.2007.02.003 Brozoski TJ, 2005, HEARING RES, V206, P227, DOI 10.1016/j.heares.2004.12.013 Brozoski TJ, 2007, JARO-J ASSOC RES OTO, V8, P105, DOI 10.1007/s10162-006-0067-2 CHEN GD, 1995, HEARING RES, V82, P158, DOI 10.1016/0378-5955(94)00174-O Eggermont JJ, 2004, TRENDS NEUROSCI, V27, P676, DOI 10.1016/j.tins.2004.08.010 Imig TJ, 2005, J COMP NEUROL, V490, P391, DOI 10.1002/cne.20674 JASTREBOFF PJ, 1988, LARYNGOSCOPE, V98, P280 Kaltenbach JA, 2005, HEARING RES, V206, P200, DOI 10.1016/j.heares.2005.02.013 KALTENBACH JA, 2000, HEARING RES, V140, P156 Liberman M C, 1978, Acta Otolaryngol Suppl, V358, P1 Lockwood AH, 1998, NEUROLOGY, V50, P114 MULHERAN M, 1999, P 16 INT TINN SEM LO, P189 SALVI RJ, 1978, EXP BRAIN RES, V32, P301 Zhang JS, 1998, NEUROSCI LETT, V250, P197, DOI 10.1016/S0304-3940(98)00482-0 Zhang JS, 2003, EXP BRAIN RES, V153, P655, DOI 10.1007/s00221-003-1612-4 NR 16 TC 1 Z9 1 PU ROYAL BELGIAN SOC EAR, NOSE, THROAT, HEAD & NECK SURGERY PI LEUVEN PA PO BOX 1248, LEUVEN, 00000, BELGIUM SN 0001-6497 J9 B-ENT JI B-ENT PY 2007 SU 7 BP 23 EP 25 PG 3 WC Otorhinolaryngology SC Otorhinolaryngology GA 240SY UT WOS:000251608900005 ER PT J AU Nowe, V Van de Heyning, P Parizel, PM AF Nowe, V. Van de Heyning, P. Parizel, P. M. TI MRI in patients with otovestibular complaints of unknown origin SO B-ENT LA English DT Article DE MRI; WML; neurovascular conflict; hearing loss; tinnitus; vertigo ID ATTENUATED INVERSION-RECOVERY; WHITE-MATTER HYPERINTENSITIES; MULTIPLE-SCLEROSIS LESIONS; FAST SPIN-ECHO; VASCULAR-DECOMPRESSION SURGERY; MICROVASCULAR DECOMPRESSION; TRIGEMINAL NEURALGIA; SEVERE TINNITUS; COMPRESSION SYNDROME; HEMIFACIAL SPASM AB MRI in patients with otovestibular complaints of unknown origin. Objectives: The place of MRI in the diagnostic work-up of patients with bilateral perceptive hearing loss, tinnitus and vertigo is under discussion. The purpose of this study is to investigate the role of MRI in patients with otovestibular and cranial nerve complaints of unknown aetiology. Methodology: After thorough otologic examination, 430 patients were consecutively referred for an MR examination of the cerebellopontine angle. Results: The detection rate for essential lesions was 4.9%. Two groups of retrocochlear lesions were frequently observed: central WMLs/atrophy and neurovascular conflict affecting a cranial nerve. Conclusions: MR imaging of the cerebellopontine angle, fossa posterior and petrous bones makes it possible to observe abnormalities of the vestibulocochlear nerve and inner ear. Additional T2-weighted FSE images of the whole brain make it possible to evaluate the occurrence of early central lesions. This imaging protocol can diagnose essential lesions relating directly to the complaint in 4.9% of the patients with hearing loss, subjective tinnitus or vertigo. We frequently observed two groups of lesions of uncertain significance in our study population. WMLs are present in 50% of patients with a mean age of 59 years. In the younger subpopulation aged under 51 years the prevalence of WMLs is 24%. It remains unclear whether these lesions can be accounted for by the diversity of symptoms with which the patients presented. In addition, we found a high number of neurovascular conflicts involving different cranial nerves. C1 [Nowe, V.; Parizel, P. M.] Univ Antwerp Hosp, Dept Radiol, B-2650 Edegem, Belgium. [Van de Heyning, P.] Univ Antwerp Hosp, Dept ENT, Edegem, Belgium. RP Parizel, PM (reprint author), Univ Antwerp Hosp, Dept Radiol, Wilrijk Str 10, B-2650 Edegem, Belgium. 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Hendrickx, J. - J. Topsakal, V. Fransen, E. Van Laer, L. De Ridder, D. Van Camp, G. Van de Heyning, P. TI Prevalence of tinnitus and audiometric shape SO B-ENT LA English DT Article DE audiometric configuration; presbyacusis; prevalence; steeply sloping hearing loss; tinnitus ID BLUE MOUNTAINS HEARING; HUMAN AUDITORY-CORTEX; LATERAL INHIBITION; NOISE EXPOSURE; OLDER-ADULTS; ORGANIZATION; PERCEPTION; MECHANISMS; RESPONSES; WORKERS AB Prevalence of tinnitus and audiometric shape. Objectives: Studies of tinnitus are often conducted on patient populations presenting for treatment. It is, however, difficult to generalise prevalence numbers and aetiological results from these studies to a healthy, elderly population. The first aim of our study was to determine the prevalence of tinnitus in an otologically screened population between 55 and 1 65 years old. Secondly, both prevalence and the specific characteristics of tinnitus were compared in subjects with either a flat audiogram, a high-frequency gently sloping audiogram or a high-frequency steeply sloping audiogram. Methods: 1147 subjects (549 males and 598 females) were recruited through population registers and underwent thorough clinical and audiological examinations. Subjects who reported tinnitus in the general questionnaire about medical history and environmental exposure were invited to complete an additional questionnaire on tinnitus history. Results: The prevalence of tinnitus was 19.3% according to the general questionnaire on medical health and environmental exposure and 11.8% according to the additional detailed tinnitus-specific questionnaire. Furthermore, our results indicate that gender has a significant effect (tinnitus is more common in males than in females), as does audiometric configuration (tinnitus is more common in subjects with a high-frequency steeply sloping audiogram than in subjects with a flat audiogram). Both effects were significant in noise-/solvent-exposed subjects, as well as in non-exposed subjects. Finally, comparison of "tinnitus characteristics" in subjects categorised by audiogram configuration revealed significant differences in loudness, pitch, temporal variability and family history of tinnitus. C1 [Demeester, K.; Hendrickx, J. - J.; Topsakal, V.; De Ridder, D.; Van de Heyning, P.] Univ Antwerp Hosp UZA, Univ UA, Dept Otolaryngol, Antwerp, Belgium. [van Wieringen, A.] Katholieke Univ Leuven, Dept Neurosci, Experimental Otolaryngol, Louvain, Belgium. [Fransen, E.; Van Laer, L.; Van Camp, G.] Univ Antwerp UA, Dept Med Genet, Antwerp, Belgium. RP Demeester, K (reprint author), Univ Antwerp Hosp, Dept Otolaryngol, Wilrijk Str 10, B-2650 Edegem, Belgium. EM kelly.demeester@ua.ac.be RI Van Camp, Guy/F-3386-2013; Fransen, Erik/C-4102-2015 OI Van Camp, Guy/0000-0001-5105-9000; Fransen, Erik/0000-0001-7785-4790 CR Ahmad N, 2004, DRUG AGING, V21, P297, DOI 10.2165/00002512-200421050-00002 ALBERTI PW, 1987, J OTOLARYNGOL, V16, P34 AXELSSON A, 1989, British Journal of Audiology, V23, P53, DOI 10.3109/03005368909077819 AXELSSON A, 1985, British Journal of Audiology, V19, P271, DOI 10.3109/03005368509078983 Axelsson A, 2000, NOISE HEALTH, V2, P47 CHUNG DY, 1984, AUDIOLOGY, V23, P441 COLES R, 1990, P 14 DAN S, P377 COOPER JC, 1976, ARCH OTOLARYNGOL, V102, P148 CORSO JF, 1976, EFFECTS NOISE HEARIN Davis A, 1998, NOISE HEALTH, V1, P40 De Ridder D, 2004, NEUROSURGERY, V54, P381, DOI 10.1227/01.NEU.0000103420.53487.79 Dias Adriano, 2006, Cad Saude Publica, V22, P63, DOI 10.1590/S0102-311X2006000100007 Dobie RA, 2005, EAR HEARING, V26, P630, DOI 10.1097/01.aud.0000188120.14321.76 Eggermont JJ, 2004, TRENDS NEUROSCI, V27, P676, DOI 10.1016/j.tins.2004.08.010 Eggermont JJ, 2003, AURIS NASUS LARYNX S, V30, P7, DOI 10.1016/S0385-8146(02)00122-0 Gerken GM, 1996, HEARING RES, V97, P75 GURR P, 1993, CLIN OTOLARYNGOL, V18, P294, DOI 10.1111/j.1365-2273.1993.tb00851.x HAZELL JWP, 1979, BRIT J HOSP MED, V22, P468 International Organization for Standardization, 1989, 8692 ISO, P1 JASTREBOFF PJ, 1990, NEUROSCI RES, V8, P221, DOI 10.1016/0168-0102(90)90031-9 Job A, 2007, AUDIOL NEURO-OTOL, V12, P137, DOI 10.1159/000099025 Kadner A, 2002, NEUROREPORT, V13, P443, DOI 10.1097/00001756-200203250-00016 Konig O, 2006, HEARING RES, V221, P59, DOI 10.1016/j.heares.2006.07.007 Kowalska Sylwia, 2001, Medycyna Pracy, V52, P305 Langguth B, 2007, PROG BRAIN RES, V166, P525, DOI 10.1016/S0079-6123(07)66050-6 Leske M C, 1981, ASHA, V23, P229 LIU XZ, 1994, ANN OTO RHINOL LARYN, V103, P428 Llinas R, 2005, TRENDS NEUROSCI, V28, P325, DOI 10.1016/j.tins.2005.04.006 Llinas RR, 1999, P NATL ACAD SCI USA, V96, P15222, DOI 10.1073/pnas.96.26.15222 Lutkenhoner B, 1998, AUDIOL NEURO-OTOL, V3, P191, DOI 10.1159/000013790 McDermott HJ, 1998, J ACOUST SOC AM, V104, P2314, DOI 10.1121/1.423744 MCKEE GJ, 1992, AUDIOLOGY, V31, P313 MCSHANE DP, 1988, CLIN OTOLARYNGOL, V13, P323, DOI 10.1111/j.1365-2273.1988.tb00760.x *MED RES COUNC I H, 1981, CIB FOUND S, V85, P16 Nicolas-Puel Cécile, 2002, Int Tinnitus J, V8, P37 Nicolas-Puel Cécile, 2006, Int Tinnitus J, V12, P64 Norena A, 2002, AUDIOL NEURO-OTOL, V7, P358, DOI 10.1159/000066156 Palmer KT, 2002, OCCUP ENVIRON MED, V59, P634, DOI 10.1136/oem.59.9.634 Pantev C, 1996, HEARING RES, V101, P62, DOI 10.1016/S0378-5955(96)00133-5 PARVING A., 1995, J AUDIOL MED, V4, P2 PHOON WH, 1993, OCCUP MED-OXFORD, V43, P35, DOI 10.1093/occmed/43.1.35 Quaranta A, 1996, Scand Audiol Suppl, V42, P9 Riga M, 2007, OTOL NEUROTOL, V28, P185, DOI 10.1097/MAO.0b013e31802e2a14 ROSENHALL U, 1991, SCAND AUDIOL, V20, P165, DOI 10.3109/01050399109074949 SATALOFF J, 1987, AM J OTOL, V8, P87 Sindhusake D, 2003, INT J AUDIOL, V42, P289, DOI 10.3109/14992020309078348 Sindhusake D, 2003, EAR HEARING, V24, P501, DOI 10.1097/01.AUD.0000100204.08771.3D Sliwinska-Kowalska M, 2004, J OCCUP ENVIRON MED, V46, P30, DOI 10.1097/01.jom.0000105912.29242.5b STOUFFER JL, 1990, J SPEECH HEAR DISORD, V55, P439 Talavage TM, 2000, HEARING RES, V150, P225, DOI 10.1016/S0378-5955(00)00203-3 Temmel AFP, 1999, WIEN KLIN WOCHENSCHR, V111, P891 Van Eyken E, 2007, J MED GENET, V44, DOI 10.1136/jmg.2007.049205 WALSH PG, 2001, AUST N Z J AUDIOL, V23, P161 Weisz N, 2006, HEARING RES, V222, P108, DOI 10.1016/j.heares.2006.09.003 Wuyts F. L., 1998, DEV GENETIC HEARING, P54 NR 55 TC 9 Z9 9 PU ROYAL BELGIAN SOC EAR, NOSE, THROAT, HEAD & NECK SURGERY PI LEUVEN PA PO BOX 1248, LEUVEN, 00000, BELGIUM SN 0001-6497 J9 B-ENT JI B-ENT PY 2007 SU 7 BP 37 EP 49 PG 13 WC Otorhinolaryngology SC Otorhinolaryngology GA 240SY UT WOS:000251608900007 ER PT J AU Hendrickx, JJ Huyghe, JR Demeester, K Topsakal, V Van Eyken, E Fransen, E Maki-Torkko, E Hannula, S Jensen, M Tropitzsch, A Bonaconsa, A Mazzoli, M Espeso, A Verbruggen, K Huyghe, J Huygen, PLM Kremer, H Kunst, SJ Manninen, M Diaz-Lacava, AN Steffens, M Parving, A Pyykko, I Dhooge, I Stephens, D Orzan, E Pfister, MHF Bille, M Sorri, M Cremers, CWRJ Van Laer, L Van Camp, G Wienker, TE Van de Heyning, P AF Hendrickx, J. -J. Huyghe, J. R. Demeester, K. Topsakal, V. Van Eyken, E. Fransen, E. Maeki-Torkko, E. Hannula, S. Jensen, M. Tropitzsch, A. Bonaconsa, A. Mazzoli, M. Espeso, A. Verbruggen, K. Huyghe, J. Huygen, P. L. M. Kremer, H. Kunst, S. J. Manninen, M. Diaz-Lacava, A. N. Steffens, M. Parving, A. Pyykkoe, I. Dhooge, I. Stephens, D. Orzan, E. Pfister, M. H. F. Bille, M. Sorri, M. Cremers, C. W. R. J. Van Laer, L. Van Camp, G. Wienker, T. E. Van de Heyning, P. TI Familial aggregation of tinnitus: a European multicentre study SO B-ENT LA English DT Article DE tinnitus; etiology; familial aggregation; heredity; presbyacousis ID BLUE MOUNTAINS HEARING; ENVIRONMENTAL-INFLUENCES; RELATIVE RISK; OLDER-ADULTS; ODDS RATIO; GENE; AGE; POLYMORPHISM; PRESBYCUSIS; IMPAIRMENT AB Introduction and aim: Tinnitus is a common condition affecting approximately 20% of the older population. There is increasing evidence that changes in the central auditory system following cochlear malfunctioning are responsible for tinnitus. To date, few investigators have studied the influence of genetic factors on tinnitus. The present report investigates the presence of a familial effect in tinnitus subjects. Methods: In a European multicentre study, 198 families were recruited in seven European countries. Each family had at least 3 siblings. Subjects were screened for causes of hearing loss other than presbyacusis by clinical examination and a questionnaire. The presence of tinnitus was evaluated with the question "Nowadays, do you ever get noises in your head or ear (tinnitus) which usually last longer than five minutes". Familial aggregation was tested using three methods: a mixed model approach, calculating familial correlations, and estimating the risk of a subject having tinnitus if the disorder is present in another family member. Results: All methods demonstrated a significant familial effect for tinnitus. The effect persisted after correction for the effect of other risk factors such as hearing loss, gender and age. The size of the familial effect is smaller than that for age-related hearing impairment, with a familial correlation of 0.15. Conclusion: The presence of a familial effect for tinnitus opens the door to specific studies that can determine whether this effect is due to a shared familial environment or the involvement of genetic factors. Subsequent association studies may result in the identification of the factors responsible. In addition, more emphasis should be placed on the effect of role models in the treatment of tinnitus. C1 [Hendrickx, J. -J.; Demeester, K.; Van de Heyning, P.] Univ Antwerp Hosp, Dept Otorhinolaryngol, Antwerp, Belgium. [Hendrickx, J. -J.; Huyghe, J. R.; Van Eyken, E.; Fransen, E.; Van Laer, L.; Van Camp, G.] Univ Antwerp, Dept Med Genet, B-2020 Antwerp, Belgium. [Maeki-Torkko, E.; Sorri, M.] Univ Oulu, Dept Otorhinolaryngol, Oulu, Finland. [Jensen, M.; Parving, A.] Bispebjerg Hosp, Dept Audiol, DK-2400 Copenhagen, Denmark. [Tropitzsch, A.] Univ Tubingen, Dept Otorhinolaryngol, Tubingen, Germany. [Bonaconsa, A.; Orzan, E.] Univ Hosp Padua, Dept Oto Surg, Padua, Italy. [Stephens, D.] Cardiff Univ, Welsh Hearing Inst, Cardiff, Wales. [Verbruggen, K.; Huyghe, J.] Univ Hosp Gent, Dept Otorhinolaryngol, Ghent, Belgium. [Hendrickx, J. -J.; Huygen, P. L. M.; Cremers, C. W. R. J.] Univ Nijmegen, Med Ctr, Dept Otorhinolaryngol, Nijmegen, Netherlands. [Manninen, M.; Pyykkoe, I.] Univ Tampere, Dept Otorhinolaryngol, FIN-33101 Tampere, Finland. [Diaz-Lacava, A. N.; Steffens, M.; Wienker, T. E.] Univ Bonn, Inst Med Biometry & Epidemiol, D-5300 Bonn, Germany. RP Hendrickx, JJ (reprint author), Univ Antwerp Hosp, Dept Otorhinolaryngol, Antwerp, Belgium. RI Van Camp, Guy/F-3386-2013; Fransen, Erik/C-4102-2015 OI Van Camp, Guy/0000-0001-5105-9000; Fransen, Erik/0000-0001-7785-4790 CR Bespalova IN, 2001, HUM MOL GENET, V10, P2501, DOI 10.1093/hmg/10.22.2501 *CAS W RES U, 2006, SAGE REL 5 3 CHERYCROZE S, 2006, EFFECTS GENETIC HEAR, P147 Christensen K, 2001, J AM GERIATR SOC, V49, P1512, DOI 10.1046/j.1532-5415.2001.4911245.x DeStefano AL, 2003, ARCH OTOLARYNGOL, V129, P285 Eggermont JJ, 2004, TRENDS NEUROSCI, V27, P676, DOI 10.1016/j.tins.2004.08.010 Gates GA, 1999, ARCH OTOLARYNGOL, V125, P654 Hazell J, 1990, Acta Otolaryngol Suppl, V476, P202 Hoefgen B, 2005, BIOL PSYCHIAT, V57, P247, DOI 10.1016/j.biopsych.2004.11.027 Karlsson KK, 1997, EAR HEARING, V18, P114, DOI 10.1097/00003446-199704000-00003 Keen KJ, 2003, STAT MED, V22, P3229, DOI 10.1002/sim.1559 KENNEDY V, 2006, EFFECT GENENTIC HEAR, P187 LEE J, 1994, INT J EPIDEMIOL, V23, P201, DOI 10.1093/ije/23.1.201 Leske M C, 1981, ASHA, V23, P229 LUTMAN M E, 1987, British Journal of Audiology, V21, P45, DOI 10.3109/03005368709077774 LUXON LM, 1993, BRIT MED J, V306, P1490 MARION MS, 1991, MAYO CLIN PROC, V66, P614 Mcferran DJ, 2007, J LARYNGOL OTOL, V121, P201, DOI 10.1017/S0022215106002714 Molenberghs G., 2005, MODELS DISCRETE LONG PAASKE PB, 1991, ANN OTO RHINOL LARYN, V100, P647 Peifer KJ, 1999, CLIN GERIATR MED, V15, P193 Quaranta A, 1996, Scand Audiol Suppl, V42, P9 Rankinen T, 2006, ANNU REV NUTR, V26, P413, DOI [10.1146/annurev.nutr.26.061505.111218, 10.1146/annurev.nutr.26.061525.111218] ROSENHALL U, 1991, SCAND AUDIOL, V20, P165, DOI 10.3109/01050399109074949 Seligmann H, 1996, DRUG SAFETY, V14, P198 Sindhusake D, 2003, INT J AUDIOL, V42, P289, DOI 10.3109/14992020309078348 Sindhusake D, 2003, EAR HEARING, V24, P501, DOI 10.1097/01.AUD.0000100204.08771.3D SMOORENBURG GF, 1993, AUDIOLOGY, V32, P333 Sourgen P M, 1998, S Afr J Commun Disord, V45, P61 STOUFFER JL, 1990, J SPEECH HEAR DISORD, V55, P439 Tyler RS, 2006, ORL J OTO-RHINO-LARY, V68, P14, DOI 10.1159/000090486 Unal M, 2005, LARYNGOSCOPE, V115, P2238, DOI 10.1097/01.mlg.0000183694.10583.12 Van Eyken E, 2006, HUM MUTAT, V27, P1007, DOI 10.1002/humu.20375 Van Eyken E, 2007, J MED GENET, V44, DOI 10.1136/jmg.2007.049205 Verstreken M, 2001, OTOL NEUROTOL, V22, P874, DOI 10.1097/00129492-200111000-00028 Viljanen A, 2007, J GERONTOL A-BIOL, V62, P447 Zhang J, 1998, JAMA-J AM MED ASSOC, V280, P1690, DOI 10.1001/jama.280.19.1690 NR 37 TC 2 Z9 2 PU ROYAL BELGIAN SOC EAR, NOSE, THROAT, HEAD & NECK SURGERY PI LEUVEN PA PO BOX 1248, LEUVEN, 00000, BELGIUM SN 0001-6497 J9 B-ENT JI B-ENT PY 2007 SU 7 BP 51 EP 60 PG 10 WC Otorhinolaryngology SC Otorhinolaryngology GA 240SY UT WOS:000251608900008 ER PT J AU Gordts, F Decreton, S AF Gordts, F. Decreton, S. TI Tinnitus in children and adolescents SO B-ENT LA English DT Article DE tinnitus; children; adolescents ID CHILDHOOD; HEARING AB Tinnitus in children and adolescents. ENT practitioners are rarely confronted with tinnitus complaints from children. The present paper describes a literature review conducted in an attempt to identify possible reasons for this. Rather than applying the vast amount of information about tinnitus among adults, it seeks to highlight those domains where differences between children and adults are of importance. C1 [Gordts, F.] Univ Ziekenhuis Brussel, ENT Dept, Brussels, Belgium. [Decreton, S.] Rehabil Ctr De Poolster, Brussels, Belgium. RP Gordts, F (reprint author), Univ Ziekenhuis Brussel, ENT Dept, Brussels, Belgium. CR Akagi H, 2001, INT J PEDIATR OTORHI, V61, P259, DOI 10.1016/S0165-5876(01)00576-6 Aksoy S, 2007, INT J PEDIATR OTORHI, V71, P263, DOI 10.1016/j.ijporl.2006.10.008 Aust Gottfried, 2002, Int Tinnitus J, V8, P20 BENDAVID J, 1995, INT TINNITUS J, V1, P155 BLACK FO, 2003, PEDIAT OTOLARYNGOLOG, V1, P359 CHOUNG YH, 2006, L LARYNGOL OTOL, V120, P343 DRAPER WL, 1967, LARYNGOSCOPE, V77, P636, DOI 10.1288/00005537-196704000-00016 FAUSTI SA, 1984, AM J OTOLARYNG, V5, P177, DOI 10.1016/S0196-0709(84)80009-5 Graham J.M., 1987, TINNITUS, P131 Holgers KM, 2006, INT J AUDIOL, V45, P267, DOI 10.1080/14992020500485668 Joint Committee on Infant Hearing, 1995, PEDIATRICS, V95, P152 Kemp DT, 1979, SCAND AUDIOL S, V9, P35 Kentish RC, 2000, BRIT J AUDIOL, V34, P335 NODAR R, 1984, J LARYNGOL OTOL S, V9, P234 NODAR R, 1972, AUDITORY RES, V12, P133 PARNES LS, 1987, PEDIATRICS, V80, P524 Rodriguez-Casero MV, 2005, INT J PEDIATR OTORHI, V69, P123, DOI 10.1016/j.ijporl.2004.08.006 ROSS M, 1967, ARCHIV OTOLARYNGOL, V86, P639 Savastano M, 2007, EUR J PEDIATR, V166, P797, DOI 10.1007/s00431-006-0320-z Savastano M, 2002, INT J PEDIATR OTORHI, V64, P23, DOI 10.1016/S0165-5876(02)00031-9 SHAMBAUGH GE, 1973, OTOLARYNGOLOGY, V2, P113 SURR RK, 1985, EAR HEARING, V6, P71, DOI 10.1097/00003446-198503000-00002 Truy E, 1999, Ann Otolaryngol Chir Cervicofac, V116, P92 Widén S E Olsen, 2004, Noise Health, V7, P29 NR 24 TC 1 Z9 1 PU ROYAL BELGIAN SOC EAR, NOSE, THROAT, HEAD & NECK SURGERY PI LEUVEN PA PO BOX 1248, LEUVEN, 00000, BELGIUM SN 0001-6497 J9 B-ENT JI B-ENT PY 2007 SU 7 BP 61 EP 63 PG 3 WC Otorhinolaryngology SC Otorhinolaryngology GA 240SY UT WOS:000251608900009 ER PT J AU Vermeire, K Heyndrickx, K De Ridder, D Van de Heyning, P AF Vermeire, K. Heyndrickx, K. De Ridder, D. Van de Heyning, P. TI Phase-shift tinnitus treatment: an open prospective clinical trial SO B-ENT LA English DT Article DE tinnitus; treatment; clinical trial; pure tones ID RETRAINING THERAPY AB Phase-shift tinnitus treatment: an open prospective clinical trial. We report on a novel treatment for tinnitus using phase-shift pure tone sound treatment in patients with predominantly pure tone tinnitus. Thirty-five patients with pure tone tinnitus unresponsive to all previous treatment were enrolled in the study. All patients were treated three times in one week. If the patient noticed an improvement, the therapy was continued for six weeks with a home device customised to their specific treatment frequency. Twenty-one of the 35 patients (60%) responded positively to the initial therapy sessions. Tinnitus was assessed before treatment, after three in-office Tinnitus Phase-Out (TM) System therapy sessions, and after six weeks of home use of the Patient Treatment Device. The assessment instruments were a VAS loudness scale and the quality of life Tinnitus Questionnaire. Significant tinnitus reduction was obtained on VAS after three office Tinnitus Phase-OUtTM System therapy sessions (before treatment: mean VAS = 6.4; after three therapy sessions: mean VAS = 4.9; p = 0.042) and after six weeks of home use of the Patient Treatment Device (mean VAS = 4.9; p = 0.005). When analysing the mean TQ score over treatment, there was a significant improvement in total score from pretreatment (mean TQ score = 41.9) to six weeks after home use of the Patient Treatment Device use (mean TQ score = 36.4) (p = 0.003). In view of the results obtained, the Phase-Out Treatment (TM) for tinnitus may provide the majority of patients with a significant improvement in their symptoms. Further evaluation, comparing this specific Phase-Out Treatment (TM) with more general noise stimulation treatment, will further specify the indications for this treatment option. C1 [Vermeire, K.; Heyndrickx, K.; Van de Heyning, P.] Univ Antwerp Hosp, Dept Otolaryngol Head & Neck Surg, Antwerp, Belgium. [De Ridder, D.] Univ Antwerp Hosp, Dept Neurosurg, Antwerp, Belgium. RP Vermeire, K (reprint author), Univ Antwerp Hosp, Dept Otolaryngol Head & Neck Surg, Antwerp, Belgium. CR Caffier PP, 2006, EAR HEARING, V27, P619, DOI 10.1097/01.aud.0000240504.77861.1a Davis PB, 2007, EAR HEARING, V28, P242, DOI 10.1097/AUD.0b013e3180312619 DAVIS PB, 2005, TINNITUS TREATMENTS, P146 Demeester K, 2007, B-ENT, V3 Suppl 7, P37 GOEBEL G, 1994, HNO, V42, P166 HALLAM RS, 1988, BRIT J CLIN PSYCHOL, V27, P213 Herraiz C, 2005, OTOLARYNG HEAD NECK, V133, P774, DOI 10.1016/j.otohns.2005.07.006 JASTREBOFF PJ, 1993, BRIT J AUDIOL, V27, P7, DOI 10.3109/03005369309077884 Jastreboff PJ, 1996, P 5 INT TINN SEM POR, P500 Jastreboff PJ, 2004, TINNITUS RETRAINING Jastreboff PJ, 2006, ORL-J OTO-RHIN-LARYN, V68, P23, DOI 10.1159/000090487 Kleinjung T, 2005, OTOLARYNG HEAD NECK, V132, P566, DOI 10.1016/j.otohns.2004.09.134 Lipman RI, 2007, OTOLARYNG HEAD NECK, V136, P763, DOI 10.1016/j.otohns.2006.10.046 Martinez Devesa P., 2007, COCHRANE DB SYST REV, V1, DOI DOI 10.1002/14651858.CD005233.PUB2 TYLER RS, 2005, TINNITUS TREATMENT C, P22 NR 15 TC 4 Z9 4 PU ROYAL BELGIAN SOC EAR, NOSE, THROAT, HEAD & NECK SURGERY PI LEUVEN PA PO BOX 1248, LEUVEN, 00000, BELGIUM SN 0001-6497 J9 B-ENT JI B-ENT PY 2007 SU 7 BP 65 EP 69 PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA 240SY UT WOS:000251608900010 ER PT J AU Desloovere, C AF Desloovere, C. TI Hyperbaric oxygen therapy for tinnitus SO B-ENT LA English DT Article DE hyperbaric oxygenation; tinnitus AB Hyperbaric oxygen therapy for tinnitus. Objective: To assess the effect of hyperbaric oxygenation on tinnitus. Methodology: A Medline search from 1960-2007 yielding 22 studies. Results: No significant effect could be demonstrated in four prospective studies. Retrospective studies indicate greater improvement in tinnitus in acute cases (49-85%) compared with tinnitus episodes exceeding three months (34-38%). One study, however, showed significantly more improvement in patients with positive expectations before therapy (60.3%) compared with those with negative expectations (19%). Conclusions: There are no significant data about the effect of hyperbaric oxygenation for tinnitus, but there are indications of a better effect in acute cases. However, a major psychological component and a low risk of enhancement of the tinnitus should be considered. C1 [Desloovere, C.] Catholic Univ Leuven, Univ Hosp, Dept Otolaryngol Head & Neck Surg, Louvain, Belgium. RP Desloovere, C (reprint author), Catholic Univ Leuven, Univ Hosp, Dept Otolaryngol Head & Neck Surg, Louvain, Belgium. CR Bennett MH, 2007, COCHRANE DB SYST REV, V1, DOI DOI 10.1002/14651858.CD004739.PUB3 Delb W, 1999, HNO, V47, P1038, DOI 10.1007/s001060050488 Desloovere C, 2006, B-ENT, V2, P69 FURST G, 1994, OTORHINOLARYNGOL NOV, V4, P61 HOFFMAN G, 1993, P 11 INT C HYP MED F, P146 HOFFMANN G, 1993, P 11 INT C HYP MED, P141 HOING R, 1996, HNO INFO, V21, P167 Kau RJ, 1997, ORL J OTO-RHINO-LARY, V59, P79 Lamm K, 1998, ADV OTO-RHINO-LARYNG, V54, P59 Lamm K, 1998, ADV OTO-RHINO-LARYNG, V54, P86 SCHWAB B, 1998, COLL MAN 14 ANN SCI, P40 Stiegler P, 2006, UNDERSEA HYPERBAR M, V33, P429 Tan J, 1999, SCAND AUDIOL, V28, P91, DOI 10.1080/010503999424815 NR 13 TC 0 Z9 0 PU ROYAL BELGIAN SOC EAR, NOSE, THROAT, HEAD & NECK SURGERY PI LEUVEN PA PO BOX 1248, LEUVEN, 00000, BELGIUM SN 0001-6497 J9 B-ENT JI B-ENT PY 2007 SU 7 BP 71 EP 74 PG 4 WC Otorhinolaryngology SC Otorhinolaryngology GA 240SY UT WOS:000251608900011 ER PT J AU Maudoux, A Bonnet, S Lhonneux-Ledoux, E Lefebvre, P AF Maudoux, A. Bonnet, S. Lhonneux-Ledoux, E. Lefebvre, Ph. TI Ericksonian hypnosis in tinnitus therapy SO B-ENT LA English DT Article DE subjective tinnitus; behavioural medicine; psychotherapy; hearing loss ID CLIENT-CENTERED HYPNOTHERAPY; SELF-HYPNOSIS AB Ericksonian hypnosis in tinnitus therapy. Objective: To evaluate the effect of Ericksonian therapy on tinnitus Study Design: Non-randomised, prospective longitudinal study. Setting: Tertiary referral centre. Patients: A total of 49 patients underwent hypnosis therapy. Fourteen patients failed to finish the therapy (drop-out rate: 35%). Of the 35 patients who completed the therapy, 20 were male and 15 female. The average age was 46.3 years (range 17-78). Intervention: The treatment is based on the principles and approaches of Ericksonian hypnosis. The first session was mainly dedicated to the evaluation of the impact of tinnitus on the patient's life and to an explanation of hypnosis therapy. The next sessions were "learning sessions" based on relaxation and mental imaging. Exercises were first based on all senses other than hearing. Then they focused on hearing, teaching patients how to modulate sound intensity, and finally how to modulate tinnitus intensity. Patients also learnt self-hypnosis. Main Outcome Measure(s): To evaluate the effect of the treatment, tinnitus was assessed with the Tinnitus Handicap Inventory questionnaire before and after the therapy. Results: After 5 to 10 sessions (mean: 8.09 + -1.92) of Ericksonian hypnosis therapy, the 35 patients were capable of self-hypnosis with the aim of modulating their tinnitus, and the measured THI score fell for all patients. The global score improved significantly from 60:23 before EH therapy to 16.9 at discharge. Within the group, the initial score was distributed as follows: 0% slight, 14% mild, 3 1 % moderate, 31 % severe and 23% catastrophic. The t-test for dependent variables revealed significant improvements in all subgroups (p <= 50.005). Conclusions: The results of this clinical trial demonstrate that Ericksonian hypnosis, in particular using self-hypnosis, is a promising technique for treating patients with tinnitus. C1 [Maudoux, A.; Bonnet, S.; Lhonneux-Ledoux, E.; Lefebvre, Ph.] Univ Liege, Dept Otorhinolaryngol, Liege, Belgium. RP Maudoux, A (reprint author), Univ Liege, Dept Otorhinolaryngol, Liege, Belgium. CR ATTIAS J, 1990, SCAND AUDIOL, V19, P245, DOI 10.3109/01050399009070779 ATTIAS J, 1993, AUDIOLOGY, V32, P205 Barnes L. 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Menovsky, T. Van de Heyning, P. TI An otoneurosurgical approach to non-pulsatile and pulsatile tinnitus SO B-ENT LA English DT Article DE electrical stimulation; implant; pulsatile; surgery; tinnitus ID VASCULAR-DECOMPRESSION SURGERY; BONE-CONDUCTION EXPERIMENTS; MIDDLE-EAR MYOCLONUS; 8TH CRANIAL NERVE; ARACHNOID CYSTS; AUDITORY-CORTEX; NEUROVASCULAR COMPRESSION; CEREBELLOPONTINE ANGLE; ELECTRICAL-STIMULATION; COCHLEAR IMPLANTATION AB An otoneurosurgical approach to non-pulsatile and pulsatile tinnitus. Objective: Most treatments proposed for tinnitus are non-surgical, to such an extent that it is sometimes forgotten that a certain number of patients with tinnitus may benefit from a surgical solution. The aim of this paper is to review the possible otoneurosurgical approaches in tinnitus treatment, treating the tinnitus causally or symptomatically. Methods: A Pubmed search on the words "surgery", "tinnitus" and "pulsatile" was performed and compared to the authors' personal experience with surgical approaches for alleviating tinnitus. The most relevant different pathologies presenting as pulsatile and non-pulsatile tinnitus are given and possible otoneurosurgical approaches for these identities summarised. Results and discussion: Non-pulsatile tinnitus can be the clinical expression of vestibular schwannomas and other cerebellopontine angle lesions, arachnoid cysts, Meniere's disease, otosclerosis, brain tumours along the auditory pathways, Chiari malformations and microvascular compressions of the vestibulocochlear nerve. Symptomatic improvement of non-pulsatile tinnitus can also be obtained by electrical stimulation of the cochlea, auditory nerve or cortex. Pulsatile tinnitus can present as a venous hum resulting from benign intracranial hypertension, Chiari malformation and a high jugular bulb. Arterial-pulse-synchronous tinnitus can be caused by benign intracranial hypertension, arteria carotid stenosis, glomus tumours, vascular lesions of the petrous bone and skull base, ateriovenous malformations, aneurysms, and vascular loops inside the internal auditory canal. Conclusion: Before people are told "to learn to live with their tinnitus" a thorough exploration of possible cause and potential surgical treatments should be provided for patients presenting with incapacitating tinnitus. C1 [De Ridder, D.; Menovsky, T.; Van de Heyning, P.] TRI Tinnitus Clin Antwerp, Dept Neurosurg, Antwerp, Belgium. [Van de Heyning, P.] Univ Hosp Antwerp, ENT, Antwerp, Belgium. RP De Ridder, D (reprint author), TRI Tinnitus Clin Antwerp, Dept Neurosurg, Antwerp, Belgium. 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A. Fraser, W. D. Mackenzie, I. J. TI Detection of hearing impairment and handicap in Paget's disease of bone using a simple scoring system: A case control study SO BONE LA English DT Article DE Paget's disease of bone; deafness; screening; hearing handicap; audiometry; hearing handicap inventory for the elderly ID TEMPORAL BONE; OLDER ADULTS AB Paget's disease of bone is known to be associated with hearing loss but there are limited data on the prevalence of hearing impairment and handicap in people with Paget's disease. Previous published population studies have used patient-completed questionnaires or review of GP records, none have included audiometry. 80 Paget's subjects were selected at random from a hospital database, 75 (94%) entered the study and were matched by age and gender with 76 controls. All participants completed a screening questionnaire for hearing handicap, the HHIE-S; a questionnaire on perception of hearing-related handicap, noise exposure, hearing aids and GP consultations regarding hearing; and audiometry. The results show significant problems from hearing loss in people with Paget's disease of bone. Paget's patients were significantly more likely to perceive hearing handicap (P=0.0001), 41% Paget's patients rated themselves moderate-severe compared to none of the controls. Paget's patients were significantly more likely to report difficulties such as hearing normal speech, watching TV or hearing over background noise (all P = 0.0001). They were more likely to consult their GP due to hearing problems (P=0.004) or tinnitus (P=0.0001), or use a hearing aid (P=0.0001). Audiometry confirmed higher rates of deafness in Paget's patients. 41/75 Paget's patients compared to 19/76 controls had at least 40 decibels hearing loss (dBHL) (P=0.0001). The HHIE-S proved to be an effective screening tool. A score of greater than 8 increased the odds ratio of detecting moderate hearing impainnent (> 40 dBHL) in people with Paget's disease by 5.1. The specificity of HHIE-S > 8 as a screening tool to select for audiometry appears good, 1/46 (2%) of Paget's patients would have proved to have normal hearing thresholds. The sensitivity is better with worse hearing loss, 7/16 Paget's patients with moderate loss (> 40 dBHL) and 2/25 with severe-profound loss (> 60 dBHL) would have been missed. In conclusion, 55% unselected Paget's patients have at least moderate levels of hearing loss, compared to 25% of age and gender matched controls. Paget's patients and controls under-reported hearing problems, many of which can be ameliorated. Screening for hearing problems in Paget's disease of bone can be done using the HHIE-S. (c) 2006 Elsevier Inc. All rights reserved. C1 Walton Ctr Neurol & Neurosurg, Liverpool L9 7LJ, Merseyside, England. 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Tonkic, A. Jukic, I Buca, A. Kolic, K. Batinic, T. TI Tinnitus caused by vertebrobasilar dolichoectasia SO BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY LA English DT Article DE tinnitus; vertebrobasilar artery; dolichoectasia; MSCT angiography ID BLUE MOUNTAINS HEARING; CEREBRAL ANEURYSMS; VERTEBRAL ARTERY; OLDER-ADULTS; ANGIOGRAPHY; RISK AB A 73-year old man presented with the tinnitus in the left ear for 11 months. Computer tomography (CT) showed an enlarged dolichoectasia of the left vertebral artery. Magnetic resonance imaging (MRI) of the brain shows dolichoectasia of the left vertebral artery and the initial part of the basilar artery. Multi-slices computer tomographic (MSCT) angiography showed an enlarged vertebrobasilar dolichoectasia of the left vertebral artery, which compressed the vestibulocochlear nerve. This study supports a vascular compression of cranial vestibulocochlear nerve and the brainstem as a cause of tinnitus, and demonstrates a MSCT angiography value as an excellent, non-invasive technique to demonstrate the compression (Fig. 1, Ref. 20). C1 [Titlic, M.] Univ Hosp Split, Dept Neurol, Split, Croatia. [Tonkic, A.; Jukic, I] Univ Hosp Split, Dept Internal Med, Split, Croatia. [Buca, A.; Kolic, K.; Batinic, T.] Univ Hosp, Div Neuroradiol, Dept Radiol, Split, Croatia. RP Titlic, M (reprint author), Univ Hosp Split, Dept Neurol, Split, Croatia. 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Med. J. PY 2007 VL 108 IS 10-11 BP 455 EP 457 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA 278FN UT WOS:000254270300007 PM 18306726 ER PT J AU May, A Hajak, G Ganssbauer, S Steffens, T Langguth, B Kleinjung, T Eichhammer, P AF May, A. Hajak, G. Gaenssbauer, S. Steffens, T. Langguth, B. Kleinjung, T. Eichhammer, P. TI Structural brain alterations following 5 days of intervention: Dynamic aspects of neuroplasticity SO CEREBRAL CORTEX LA English DT Article DE auditory cortex; plasticity; rTMS; voxel-based morphometry ID TRANSCRANIAL MAGNETIC STIMULATION; ADULT HUMAN BRAINS; AUDITORY HALLUCINATIONS; MOTOR CORTEX; TINNITUS; RTMS; RAT; SCHIZOPHRENIA; PLASTICITY; EPILEPSY AB Activation-dependent brain plasticity in humans on a structural level has been demonstrated in adults after 3 months of training a visiomotor skill. The exact timescale of usage-dependent structural changes, whether days, months, or years, is, however, still debated. A better understanding of the temporal parameters may help elucidate to what extent this type of cortical plasticity contributes to fast adapting cortical processes that may be relevant to learning and effects of treatments. Using voxel-based morphometry, we are able to show that repetitive transcranial magnetic stimulation delivered to the superior temporal cortex causes macroscopic cortical changes in gray matter (GM) in the auditory cortex as early as within 5 days of continuous intervention. These structural alterations are mirrored by changes in cortical evoked potentials attributed to the GM changes and demonstrate the rapid dynamics of these processes, which occur within a time range characteristic for the onset of behavioral effects induced by a variety of treatment methods for neuropsychiatric diseases. Our finding suggests that cortical plasticity on a structural level in adult humans is already detectable after 1 week, which provides support for fast adjusting neuronal systems, such as spine and synapse turnover, and contradicts slow evolving mechanisms, such as neuronal or glial cell genesis. C1 Univ Hamburg, Dept Syst Neurosci, D-20246 Hamburg, Germany. Univ Regensburg, Dept Psychiat & Psychotherapy, D-93059 Regensburg, Germany. Univ Regensburg, Dept Neurol, D-93059 Regensburg, Germany. Univ Regensburg, Dept ENT, D-93059 Regensburg, Germany. RP May, A (reprint author), Univ Hamburg, Krankenhaus Eppendorf, Dept Syst Neurosci, Martinistr 52, D-20246 Hamburg, Germany. 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Cortex PD JAN PY 2007 VL 17 IS 1 BP 205 EP 210 DI 10.1093/cercor/bhj138 PG 6 WC Neurosciences SC Neurosciences & Neurology GA 117TP UT WOS:000242896500020 PM 16481564 ER PT J AU Dvorakova, J Anders, M Paclt, I Raboch, J Holcat, M Rathova, L Langguth, B AF Dvorakova, J. Anders, M. Paclt, I. Raboch, J. Holcat, M. Rathova, L. Langguth, B. TI Repetitive transcranial magnetic stimulation and chronic subjective tinnitus SO CESKA A SLOVENSKA NEUROLOGIE A NEUROCHIRURGIE LA Czech DT Review DE chronic tinnitus; auditory cortex, hyperexcitability; repetitive transcranial magnetic stimulation; long-term depression; phantom auditory perception ID MOTOR CORTEX EXCITABILITY; AUDITORY-CORTEX; SUPPRESSION; DEPRESSION; PLASTICITY; RTMS AB Chronic tinnitus is a frequent and often severely disabling disorder with a prevalence of over 8 % in subjects over 50 years. Tinnitus disrupts the full-value life of the patient and it is difficult to treat. The disorder is frequently associated with hearing loss and may be the result of neuroplastic alterations within the brain. Neuroimaging studies demonstrate increased activity within the central auditory system. TMS is a non-invasive method uses electromagnetic principles. TMS allows to modulate the excitability within superficial cortical areas. Stimulation effects can propagate also to functionally connected remote brain areas. It has been successfully employed in the treatment of other conditions associated with increased activity of the cerebral cortex. Applied as low frequency rTMS it has been proven to be effective for the treatment of disorders which are associated with focal hyperexcitability such as auditory hallucinations. There is a good theoretical basis and increasing research evidence suggesting a potential of TMS for the treatment of tinnitus. Further studies with large sample sizes and additional assessment of neurobiological effects are needed. Within this paper we discuss the potential for TMS as a therapy of tinnitus. C1 [Dvorakova, J.; Anders, M.; Paclt, I.; Raboch, J.] Psychiat Klin 1 LF UK VFN, Prague 12128, Czech Republic. [Holcat, M.; Rathova, L.] Psychiat Otorhinolaryngol 1 LF UK VFN, Prague 12128, Czech Republic. [Langguth, B.] Univ Regensburg, Klin Psychiat Psychosomatiku Psychoterapii, Nemecko, Germany. RP Dvorakova, J (reprint author), Psychiat Klin 1 LF UK VFN, Ke Karlovu 11, Prague 12128, Czech Republic. 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Slov. Neurol. Neurochir. PY 2007 VL 70 IS 4 BP 371 EP 374 PG 4 WC Neurosciences; Surgery SC Neurosciences & Neurology; Surgery GA 292KF UT WOS:000255264200002 ER PT J AU Shamji, MF Schramm, DR Benoit, BG AF Shamji, Mohammed F. Schramm, David R. Benoit, Brien G. TI Clinical predictors of facial nerve outcome after translabyrinthine resection of acoustic neuromas SO CLINICAL AND INVESTIGATIVE MEDICINE LA English DT Article ID VESTIBULAR SCHWANNOMA SURGERY; CEREBROSPINAL-FLUID LEAK; VASOACTIVE TREATMENT; SURGICAL SALVAGE; REMOVAL; PRESERVATION; RAT; IRRADIATION; COCHLEAR AB Purpose: The translabyrinthine approach to acoustic neuroma resection offers excellent exposure for facial nerve dissection with 95% preservation of anatomic continuity. Acceptable outcome in facial asymptomatic patients is reported at 64-90%, but transient postoperative deterioration often occurs. The objective of this study was to identify preoperative clinical presentation and intraoperative surgical findings that predispose patients to facial nerve dysfunction after acoustic neuroma surgery. Methods: The charts of 128 consecutive translabyrinthine patients were examined retrospectively to identify new clinical and intraoperative predictors of facial nerve outcome. Postoperative evaluation of patients to normal function or mild asymmetry upon close inspection (House-Brackmann grades of I or II) was defined as an acceptable outcome, with obvious asymmetry to no movement (grades III to VI) defined as unacceptable. Intraoperative nerve stimulation was performed in all cases, and clinical grading was performed by a single neurosurgeon in all cases. Results: Among patients with no preoperative facial nerve deficit, 87% had an acceptable result. Small size (P < 0.01) and low intraoperative nerve stimulation of < 0.10 mA (P < 0.01) were reaffirmed as predictive of functional nerve preservation. Additionally, preoperative tinnitus (P = 0.03), short duration of hearing loss (P < 0. 01), and lack of subjective tumour adherence to the facial nerve (P = 0.02) were independently correlated with positive outcome. Conclusions: Our experience with the translabyrinthine approach reveals the previously unestablished associations of facial nerve outcome to include presence of tinnitus and duration of hypoacusis. Independent predictors of tumour size and nerve stimulation thresholds were reaffirmed, and the subjective description of tumour adherence to the facial nerve making dissection more difficult appears to be important. C1 [Shamji, Mohammed F.; Benoit, Brien G.] Ottawa Civic Hosp, Div Neurosurg, Ottawa, ON K1Y 4E9, Canada. [Schramm, David R.] Duke Univ, Dept Biomed Engn, Durham, NC 27708 USA. Ottawa Civic Hosp, Dept Otolaryngol, Ottawa, ON K1Y 4E9, Canada. RP Shamji, MF (reprint author), 2616 Erwin Rd,1416, Durham, NC 27705 USA. 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Invest. Med. PY 2007 VL 30 IS 6 BP E233 EP E239 PG 7 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA 257WK UT WOS:000252829300002 PM 18053390 ER PT J AU Chyka, PA Erdman, AR Christianson, G Wax, PM Booze, LL Manoguerra, AS Caravati, EM Nelson, LS Olson, KR Cobaugh, DJ Scharman, EJ Woolf, AD Troutman, WG AF Chyka, Peter A. Erdman, Andrew R. Christianson, Gwenn Wax, Paul M. Booze, Lisa L. Manoguerra, Anthony S. Caravati, E. Martin Nelson, Lewis S. Olson, Kent R. Cobaugh, Daniel J. Scharman, Elizabeth J. Woolf, Alan D. Troutman, William G. TI Salicylate poisoning: An evidence-based consensus guideline for out-of-hospital management SO CLINICAL TOXICOLOGY LA English DT Review DE aspirin/poisoning; salicylic acid/poisoning; poison control centers/standards; practice guidelines ID ENTERIC-COATED ASPIRIN; FORCED ALKALINE DIURESIS; WHOLE-BOWEL IRRIGATION; CHOLINE MAGNESIUM TRISALICYLATE; CLINICAL-PRACTICE GUIDELINES; ORAL ACTIVATED-CHARCOAL; METHYL SALICYLATE; EXCHANGE TRANSFUSION; PULMONARY-EDEMA; PERCUTANEOUS-ABSORPTION AB A review of U.S. poison center data for 2004 showed over 40,000 exposures to salicylate-containing products. A guideline that determines the conditions for emergency department referral and pre-hospital care could potentially optimize patient outcome, avoid unnecessary emergency department visits, reduce health care costs, and reduce life disruption for patients and caregivers. An evidence-based expert consensus process was used to create the guideline. Relevant articles were abstracted by a trained physician researcher. The first draft of the guideline was created by the lead author. The entire panel discussed and refined the guideline before distribution to secondary reviewers for comment. The panel then made changes based on the secondary review comments. The objective of this guideline is to assist poison center personnel in the appropriate out-of-hospital triage and initial out-of-hospital management of patients with a suspected exposure to salicylates by 1) describing the process by which a specialist in poison information should evaluate an exposure to salicylates, 2) identifying the key decision elements in managing cases of salicylate exposure, 3) providing clear and practical recommendations that reflect the current state of knowledge, and 4) identifying needs for research. This guideline is based on an assessment of current scientific and clinical information. The expert consensus panel recognizes that specific patient care decisions may be at variance with this guideline and are the prerogative of the patient and the health professionals providing care, considering all of the circumstances involved. This guideline does not substitute for clinical judgment. Recommendations are in chronological order of likely clinical use. The grade of recommendation is in parentheses: 1) Patients with stated or suspected self-harm or who are the victims of a potentially malicious administration of a salicylate, should be referred to an emergency department immediately. This referral should be guided by local poison center procedures. In general, this should occur regardless of the dose reported (Grade D). 2) The presence of typical symptoms of salicylate toxicity such as hematemesis, tachypnea, hyperpnea, dyspnea, tinnitus, deafness, lethargy, seizures, unexplained lethargy, or confusion warrants referral to an emergency department for evaluation (Grade C). 3) Patients who exhibit typical symptoms of salicyiate toxicity or nonspecific symptoms such as unexplained lethargy, confusion, or dyspnea, which could indicate the development of chronic salicylate toxicity, should be referred to an emergency department (Grade Q. 4) Patients without evidence of self-harm should have further evaluation, including determination of the dose, time of ingestion, presence of symptoms, history of other medical conditions, and the presence of co-ingestants. The acute ingestion of more than 150 mg/kg or 6.5 g of aspirin equivalent, whichever is less, warrants referral to an emergency department. Ingestion of greater than a lick or taste of oil of wintergreen (98% methyl salicylate) by children under 6 years of age and more than 4 mL of oil of wintergreen by patients 6 years of age and older could cause systemic salicylate toxicity and warrants referral to an emergency department (Grade C). 5) Do not induce emesis for ingestions of salicylates (Grade D). 6) Consider the out-of-hospital administration of activated charcoal for acute ingestions of a toxic dose if it is immediately available, no contraindications are present, the patient is not vomiting, and localguidelines for its out-of-hospital use are observed. However, do not delay transportation in order to administer activated charcoal (Grade D). 7) Women in the last trimester of pregnancy who ingest below the dose for emergency department referral and do not have other referral conditions should be directed to their primary care physician, obstetrician, or a non-emergent health care facility for evaluation of maternal and fetal risk. Routine referral to an emergency department for immediate care is not required (Grade C). 8) For asymptomatic patients with dermal exposures to methyl salicylate or salicylic acid, the skin should be thoroughly washed with soap and water and the patient can be observed at home for development of symptoms (Grade Q. 9) For patients with an ocular exposure of methyl salicylate or salicylic acid, the eye(s) should be irrigated with room-temperature tap water for 15 minutes. If after irrigation the patient is having pain, decreased visual acuity, or persistent irritation, referral for an ophthalmological examination is indicated (Grade D). 10) Poison centers should monitor the onset of symptoms whenever possible by conducting follow-up calls at periodic intervals for approximately 12 hours after ingestion of non-enteric-coated salicylate products, and for approximately 24 hours after the ingestion of enteric-coated aspirin (Grade C). C1 Amer Assoc Poison Control Ctrs, Washington, DC 20016 USA. RP Chyka, PA (reprint author), Amer Assoc Poison Control Ctrs, 3201 New Mexico Ave, Washington, DC 20016 USA. 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M., 2002, Journal of Toxicology Clinical Toxicology, V40, P690 YIP L, 2004, MED TOXICOL, P739 YOUNG C J, 1952, South Med J, V45, P1075 NR 214 TC 25 Z9 25 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 0731-3810 J9 CLIN TOXICOL JI Clin. Toxicol. PY 2007 VL 45 IS 2 BP 95 EP 131 DI 10.1080/15563650600907140 PG 37 WC Toxicology SC Toxicology GA 138JT UT WOS:000244359600001 PM 17364628 ER PT J AU Bennett, MH Kertesz, T Yeung, P AF Bennett, M. H. Kertesz, T. Yeung, P. TI Hyperbaric oxygen for idiopathic sudden sensorineural hearing loss and tinnitus SO COCHRANE DATABASE OF SYSTEMATIC REVIEWS LA English DT Review ID IMPAIRMENT; DISABILITY; MANAGEMENT; DIAGNOSIS; DEAFNESS; THERAPY AB Background Idiopathic sudden sensorineural hearing loss (ISSHL) with or without tinnitus is common and presents a health problem with significant effect on quality of life. Hyperbaric oxygen therapy (HBOT) may improve oxygen supply to the inner ear and, it is postulated, may result in an improvement in hearing and/or a reduction in the intensity of tinnitus. Objectives To assess the benefits and harms of HBOT for treating ISSHL and/or tinnitus. Search strategy We initially searched in June 2004 and repeated the search in June 2006. Our search included the Cochrane Ear, Nose and Throat Disorders Group Trials Register, the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library, Issue 2 2006), MEDLINE (1951 to 2006), EMBASE (1974 to 2006), CINAHL, Database of Randomised Trials in Hyperbaric Medicine (DORCTHIM), AMED, LILACS, KOREAMED, INDMED, National Research Register (NRR), CSA, ISI PROCEEDINGS and ZETOC. Selection criteria Randomised studies comparing the effect on ISSHL and/or tinnitus of therapeutic regimens which include HBOT with those that exclude HBOT. Data collection and analysis Three authors independently evaluated the quality of the relevant trials using the validated Oxford-Scale (Jadad 1996) and extracted the data from the included trials. Main results Six trials contributed to this review (308 subjects). Pooled data from two trials involving 114 patients did not show any significant improvement in the chance of a 50% increase in hearing threshold on Pure Tone Average (PTA) when HBOT was used (relative risk [RR] with HBOT 1.53, 95% CI 0.85 to 2.78, P = 0.16), but did show a significantly increased chance of a 25% increase in PTA (RR 1.39, 95% CI 1.05 to 1.84, P = 0.02). There was a 22% greater chance of improvement with HBOT, and the number needed to treat (NNT) to achieve one extra good outcome was five (95% CI 3 to 20). A single trial involving 50 subjects also suggested significantly more improvement in the mean PTA threshold with HBOT, expressed as a percentage of baseline (WMD 37%, 95% CI 22% to 53%, P < 0.001). The significance of any improvement following HBOT in a subjective rating of tinnitus could not be assessed due to poor reporting. There were no significant improvements in hearing or tinnitus reported in the single study to examine chronic presentation (six months) of ISSHL and/or tinnitus. Authors' conclusions For people with early presentation of ISSHL, the application of HBOT significantly improved hearing loss, but the clinical significance of the level of improvement is not clear. We could not assess the effect of HBOT on tinnitus by pooled data analysis. The routine application of HBOT to these patients cannot be justified from this review. In view of the modest number of patients, methodological shortcomings and poor reporting, this result should be interpreted cautiously, and an appropriately powered trial of high methodological rigour is justified to define those patients (if any) who can be expected to derive most benefit from HBOT. There is no evidence of a beneficial effect of HBOT on chronic presentation of ISSHL and/or tinnitus and we do not recommend use of HBOT for this purpose based on the single study available. 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TI Ginkgo biloba for cognitive impairment and dementia (Review) SO COCHRANE DATABASE OF SYSTEMATIC REVIEWS LA English DT Review ID SPECIAL EXTRACT EGB-761; PRIMARY DEGENERATIVE DEMENTIA; DOUBLE-BLIND; ALZHEIMERS-DISEASE; CEREBRAL INSUFFICIENCY; MEMORY IMPAIRMENT; ELDERLY SUBJECTS; EGB 761(R); LONG-TERM; PLACEBO AB Background Extracts of the leaves of the maidenhair tree, Ginkgo biloba, have long been used in China as a traditional medicine for various disorders of health. A standardized extract is widely prescribed for the treatment of a range of conditions including memory and concentration problems, confusion, depression, anxiety, dizziness, tinnitus and headache. The mechanisms of action are thought to reflect the action of several components of the extract and include increasing blood supply by dilating blood vessels, reducing blood viscosity, modification of neurotransmitter systems, and reducing the density of oxygen free radicals. Objectives To assess the efficacy and safety of Ginkgo biloba for dementia or cognitive decline. Search strategy Trials were identified on 10 October 2006 through a search of the Cochrane Dementia and Cognitive Improvement Group's Specialized Register which contains records from all main medical databases ( MEDLINE, EMBASE, CINAHL, PsycINFO, SIGLE, LILACS), from ongoing trials databases such as Clinicaltrials.gov and Current Controlled Trials and many other sources. The search terms used were ginkgo*, tanakan, EGB-761, EGB761, "EGB 761" and gingko*. Selection criteria Randomized, double-blind studies, in which extracts of Ginkgo biloba at any strength and over any period were compared with placebo for their effects on people with acquired cognitive impairment, including dementia, of any degree of severity. Data collection and analysis Data were extracted from the published reports of the included studies, pooled where appropriate and the treatment effects or the risks and benefits estimated. Main results Clinical global improvement as assessed by the physician, was dichotomized between participants who showed improvement or were unchanged and those who were worse. There are benefits associated with Ginkgo ( dose greater than 200 mg/day) at 24 weeks (207/276 compared with 178/273, OR 1.66, 95% CI 1.12 to 2.46, P=.001) ( 2 studies), but not for the lower dose. Cognition shows benefit for Ginkgo ( any dose) at 12 weeks (SMD - 0.65, 95% CI - 1.22 to - 0.09 P=0.02, 5 studies) but not at 24 weeks. Five studies assessed activities of daily living (ADLs), using different scales. Some scales are more comprehensive than just ADLs. The results show benefit for Ginkgo ( dose less than 200 mg/day) compared with placebo at 12 weeks (MD -5.0, 95% CI -7.88, -2.12, p=0.0007, one study), and at 24 weeks ( SMD - 0.16, 95% CI - 0.31 to - 0.01, p=0.03, 3 studies) but there are no differences at the higher dose. No study assessed mood and function separately, but one study used the ADAS-Noncog, which assesses function over several domains, but not cognitive function. There was no difference between Ginkgo and placebo. There are no significant differences between Ginkgo and placebo in the proportion of participants experiencing adverse events. There are no data available on Quality of Life, measures of depression or dependency. Authors' conclusions Ginkgo biloba appears to be safe in use with no excess side effects compared with placebo. Many of the early trials used unsatisfactory methods, were small, and we cannot exclude publication bias. The evidence that Ginkgo has predictable and clinically significant benefit for people with dementia or cognitive impairment is inconsistent and unconvincing. C1 Univ Oxford, John Radcliffe Hosp, Nuffield Dept Clin Med, Oxford OX3 9DU, England. RP Birks, J (reprint author), Univ Oxford, John Radcliffe Hosp, Nuffield Dept Clin Med, CDCIG Room 5802, Oxford OX3 9DU, England. 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PY 2007 IS 2 AR CD003120 DI 10.1002/14651858.CD003120.pub2 PG 69 WC Medicine, General & Internal SC General & Internal Medicine GA 157ZK UT WOS:000245760200005 PM 17443523 ER PT J AU Martinez Devesa, P Waddell, A Perera, R Theodoulou, M AF Martinez Devesa, P. Waddell, A. Perera, R. Theodoulou, M. TI Cognitive behavioural therapy for tinnitus SO COCHRANE DATABASE OF SYSTEMATIC REVIEWS LA English DT Review ID PLACEBO-CONTROLLED TRIAL; RANDOMIZED CLINICAL-TRIAL; OCCUPATIONAL HEARING-LOSS; NOISE-EXPOSED WORKERS; ACUTE ACOUSTIC TRAUMA; DOUBLE-BLIND; GINKGO-BILOBA; PSYCHOMETRIC PROPERTIES; PSYCHOLOGICAL TREATMENT; VESTIBULAR SCHWANNOMA AB Background Tinnitus is an auditory perception that can be described as the experience of sound, in the ear or in the head, in the absence of external acoustic stimulation (not usually audible to anyone else). At present no specific therapy for tinnitus is acknowledged to be satisfactory in all patients. Cognitive behavioural therapy (CBT) uses relaxation, cognitive restructuring of the thoughts and exposure to exacerbating situations in order to promote habituation and may benefit tinnitus patients, as may the treatment of associated psychological conditions. Objectives To assess whether cognitive behavioural therapy is effective in the management of patients suffering from tinnitus. Search strategy Our search included the Cochrane ENT Group Trials Register, the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library Issue 2, 2006), MEDLINE and EMBASE. The last search date was June 2006. Selection criteria Randomised controlled trials in which patients with unilateral or bilateral tinnitus as main symptom received cognitive behavioural treatment. Data collection and analysis One review author (PMD) assessed every report identified by the search strategy. The four review authors assessed the methodological quality, applied inclusion/exclusion criteria and extracted data. Main results Six trials comprising 285 participants were included. 1. Primary outcome: subjective tinnitus loudness CBT compared to a waiting list control group: we found no significant difference (Standardised Mean Difference (SMD) 0.06 (95% CI - 0.25 to 0.37)). CBT compared to another intervention (Yoga, Education, Minimal Contact - Education and Education): we found no significant difference (SMD 0.1 (95% CI - 0.22 to 0.42)). 2. Secondary outcomes a) Depression CBT compared to a waiting list control group: we found no significant difference in either group (SMD 0.29 (95% CI - 0.04 to 0.63)). CBT compared to another intervention (Yoga, Education andMinimal Contact - Education): we found no significant difference (SMD 0.01 (95% CI - 0.43 to 0.45)). C1 Great Western Hosp, ENT Dept, Swindon SN3 6BB, Wilts, England. RP Martinez Devesa, P (reprint author), Great Western Hosp, ENT Dept, Marlborough Rd, Swindon SN3 6BB, Wilts, England. 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Design/methodology/approach - Webotherapy, which can be conducted with individuals or groups, refers to the use of web resources or other online reading material (e.g. e-books, e-journals) to assist clients (especially children and young adults) in their healing process. It may be defined as the use of web resources to help others gain additional insight and to help them cope with everyday life. Most people have probably read web resources to determine how others have approached a delicate issue. Findings - This paper suggests that webotherapy is a potentially powerful method for psychologists, librarians, schoolteachers and counselors to use on many levels. 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Yong, Mona Maceri, Dennis TI Endolymphatic sac tumor: A report of 3 cases and discussion of management SO ENT-EAR NOSE & THROAT JOURNAL LA English DT Article ID HIPPEL-LINDAU-DISEASE; LOW-GRADE ADENOCARCINOMA; GENE; FEATURES; ORIGIN; SYSTEM AB Patients with an endolymphatic sac tumor (ELST) typically present with palsy of cranial nerves VII and/or VIII; other presenting symptoms include hearing loss, otalgia, occipital headaches, cranial nerve palsies, vertigo, gait ataxia, tinnitus, and otorrhea. ELSTs are extremely vascular, and they can invade and destroy temporal bone. Because of these characteristics, they are often mistaken for glomus tumors of the skull base. We describe the clinical presentation, evaluation, and management of ELSTs based on our review of the limited literature and our experience with 3 adults who presented to our tertiary care referral center with large ELSTs. Although these patients presented late in the course of their disease, their symptoms were relatively minor Preoperative tumor embolization was performed, and a near-complete resection was achieved via an extended transotic approach in all 3 patients. The facial nerve was preserved without transposition in the first patient, the second patient underwent a primary, nerve anastomosis, and the third required a cable graft of the facial nerve. Postoperative radiation therapy was administered to 2 of these patients. Follow-up by MRI detected no evidence of recurrence in any of the 3 patients. C1 Univ So Calif, Dept Otolaryngol Head & Neck Surg, LAC & USC Med Ctr, Los Angeles, CA USA. Univ So Calif, Dept Pathol, LAC & USC Med Ctr, Los Angeles, CA USA. RP Doherty, JK (reprint author), Univ Calif San Diego, Dept Otolaryngol Head & Neck Surg, 3350 La Jolla Village Dr,9112C, La Jolla, CA 92093 USA. 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PD JAN PY 2007 VL 86 IS 1 BP 30 EP 35 PG 6 WC Otorhinolaryngology SC Otorhinolaryngology GA 151IP UT WOS:000245284000013 PM 17315832 ER PT J AU Mutter, J Naumann, J Guethlin, C AF Mutter, Joachim Naumann, Johannes Guethlin, Corina TI Elimination of xenobiotics in a female patient with fibromyalgia, chronic fatigue and trunk obesity SO FORSCHENDE KOMPLEMENTARMEDIZIN UND KLASSISCHE NATURHEILKUNDE LA German DT Article DE fibromyalgia; fatigue; isolated ACTH-deficiency; adrenocortical insufficiency, secondary; mercury; aluminium; detoxification; vaccination ID DENTAL AMALGAM FILLINGS; MERCURY EXPOSURE; PITUITARY-GLANDS; RISK-ASSESSMENT; HEALTH; REPLACEMENT; ALUMINUM; BRAIN AB We describe the case of a 28-year-old woman, who had been suffering for more than 5 years from severe fatigue, myofascial pain, obstipation, obesity of trunk, abdominal striae, oedema, tinnitus, folliculitis, and facial swelling. The patient also showed a secondary adrenocortical insufficiency. From the anamnesis we assumed that environmental factors could account for the symptoms. The therapy consisted of dietary advise, chelating agents, supplements, and acupuncture. Under this therapy the patient became completely symptom-free. No such case has ever been reported before. We report mainly on the CAM diagnostic and therapeutic procedures, which are discussed together with the assumed pathogenetic factors. C1 Univ Med Ctr Freiburg, Inst Environm Med & Hosp Epidemiol, D-79106 Freiburg, Germany. RP Mutter, J (reprint author), Univ Med Ctr Freiburg, Inst Environm Med & Hosp Epidemiol, Breisacherstr 115 B, D-79106 Freiburg, Germany. 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Komplementmed. Klass. Naturheilkd. PY 2007 VL 14 IS 1 BP 39 EP 44 DI 10.1159/000099128 PG 6 WC Integrative & Complementary Medicine SC Integrative & Complementary Medicine GA 143SY UT WOS:000244746200008 PM 17341886 ER PT J AU Hasumi, T Fukushima, T Haisa, T Yonemitsu, T Waragai, M AF Hasumi, Takashi Fukushima, Takeshi Haisa, Toshihiko Yonemitsu, Tsutomu Waragai, Masaaki TI Focal dural arteriovenous fistula (DAVF) presenting with progressive cognitive impairment including amnesia and alexia SO INTERNAL MEDICINE LA English DT Article DE dural arteriovenous fistula (DAVF); progressive cognitive impairment; amnesia; alexia ID TRANSVERSE-SIGMOID SINUS; DEMENTIA; MALFORMATIONS; PARKINSONISM; SPECT AB A 75-year-old woman with a dural arteriovenous fistula (DAVF) presented with progressive cognitive impairment including amnesia and alexia. Neuroradiological studies showed a relatively confined DAVF lesion in the left temporal lobe. The patient did not have a history of trauma and did not complain of headache or tinnitus. Amnesia and alexia dramatically improved upon treatment of the DAVF, and this was associated with attenuation of an abnormal MRI signal in the left temporal lobe. The results suggest that gradually impaired cerebral circulation due to focal venous hypertensive encephalopathy localized to the left temporal lobe and resulting from a DAVF could be involved in slowly progressive amnesia and alexia. The case also shows that an intracranial DAVF may present as a variety of neurological symptoms, depending on its localization, size and clinical stage. C1 [Hasumi, Takashi; Fukushima, Takeshi; Waragai, Masaaki] JR Tokyo Gen Hosp, Div Neurol, Tokyo, Japan. [Hasumi, Takashi; Haisa, Toshihiko; Yonemitsu, Tsutomu] JR Tokyo Gen Hosp, Dept Neurosurg, Tokyo, Japan. RP Waragai, M (reprint author), JR Tokyo Gen Hosp, Div Neurol, Tokyo, Japan. 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Med. PY 2007 VL 46 IS 16 BP 1311 EP 1320 DI 10.2169/internalmedicine.46.0262 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA 343HS UT WOS:000258844700013 ER PT J AU Miyakawa, T Kamada, N Kobayashi, T Hirano, K Fujii, K Sasahara, Y Nagai, Y Shinkai, H AF Miyakawa, Takehiko Kamada, Noriaki Kobayashi, Takashi Hirano, Keiko Fujii, Katsunori Sasahara, Yoshitaro Nagai, Yuichiro Shinkai, Hiroshi TI Neurofibromatosis type 2 in an infant with multiple plexiform schwannomas as first symptom SO JOURNAL OF DERMATOLOGY LA English DT Article DE bilateral vestibular schwannomas; multiple depigmented spots; multiple plexiform schwannomas; neurofibromatosis 2 ID GENE AB Neurofibromatosis type 2 (NF2) is an autosomal dominant disorder that is caused by inactivating mutations or a loss of both alleles in the NF2 tumor-suppressor gene. Bilateral vestibular schwannomas are considered to be the hallmark of this disease, with hearing loss and tinnitus which are caused by these tumors, usually presenting as the initial symptoms. In addition to other tumors and ocular findings, skin abnormalities also occur in NF2, however, they are not so characteristic as neurofibromatosis type 1 (NF1). We herein report a case of NF2 which occurred in a 5-year-old boy. He had multiple cutaneous tumors but did not have any symptoms related to vestibular schwannomas. He also had multiple depigmented spots. A histopathological examination revealed these tumors to be plexiform schwannomas; we therefore suspected NF2. As a result of magnetic resonance imaging with gadolinium enhancement, bilateral vestibular schwannomas were detected and a final diagnosis of NF2 was thus made. The association between NF2 and multiple depigmented spots is unknown, we therefore consider that multiple cutaneous plexiform schwannomas may strongly suggest an association with NF2. C1 Chiba Univ, Grad Sch Med, Dept Dermatol, Chuo Ku, Chiba 2608670, Japan. Chiba Univ, Grad Sch Med, Dept Pediat, Chuo Ku, Chiba 2608670, Japan. Chiba Univ, Grad Sch Med, Dept Plast Surg, Chuo Ku, Chiba 2608670, Japan. Chiba Univ, Grad Sch Med, Dept Mol Pathol, Chuo Ku, Chiba 2608670, Japan. RP Kamada, N (reprint author), Chiba Univ, Grad Sch Med, Dept Dermatol, Chuo Ku, 1-8-1 Inohana, Chiba 2608670, Japan. 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PD JAN PY 2007 VL 34 IS 1 BP 60 EP 64 DI 10.1111/j.1346-8138.2007.00218.x PG 5 WC Dermatology SC Dermatology GA 117WP UT WOS:000242904300011 PM 17204104 ER PT J AU Qureshi, AI Alexandrov, AV Tegeler, CH Hobson, RW Baker, JD Hopkins, LN AF Qureshi, Adnan I. Alexandrov, Andrei V. Tegeler, Charles H. Hobson, Robert W., II Baker, J. Dennis Hopkins, L. Nelson TI Guidelines for screening of extracranial carotid artery disease: A statement for healthcare professionals from the multidisciplinary Practice Guidelines Committee of the American Society of Neuroimaging; Cosponsored by the Society of Vascular and Interventional Neurology SO JOURNAL OF NEUROIMAGING LA English DT Review DE carotid artery; carotid stenosis; guidelines; screening; imaging; Doppler; ultrasonography ID CARDIOVASCULAR RISK-FACTORS; ABDOMINAL AORTIC-ANEURYSMS; LATE CLINICAL-OUTCOMES; IN-STENT RESTENOSIS; OPEN-HEART-SURGERY; GENERAL-POPULATION; STROKE-ASSOCIATION; RECURRENT STENOSIS; COST-EFFECTIVENESS; ATHEROSCLEROTIC DISEASE AB The aim of this new statement is to provide comprehensive and timely evidence-based recommendations on the screening for asymptomatic carotid artery stenosis in the general population and selected subsets of patients. Recommendations are included for high-risk persons in the general population; patients undergoing open heart surgery including coronary artery bypass surgery; patients with peripheral vascular diseases, abdominal aortic aneurysms, and renal artery stenosis; patients after radiotherapy for head and neck malignancies; patients following carotid endarterectomy, or carotid artery stent placement; patients with retinal ischemic syndromes; patients with syncope, dizziness, vertigo or tinnitus; and patients with a family history of vascular diseases and hyperhomocysteinemia. The recommendations are based on prevalence of disease, anticipated benefit, and concurrent guidelines from other professional organizations in selected populations. C1 Univ Minnesota, Dept Neurol, Zeenat Qureshi Stroke Res Ctr, Minneapolis, MN 55455 USA. Barrow Neurol Inst, Neurosonol & Stroke Res Program, Phoenix, AZ 85013 USA. Wake Forest Univ, Bowman Gray Sch Med, Dept Neurol, Winston Salem, NC 27103 USA. 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Neuroimaging PD JAN PY 2007 VL 17 IS 1 BP 19 EP 47 DI 10.1111/j.1552-6569.2006.00085.x PG 29 WC Clinical Neurology; Neuroimaging; Radiology, Nuclear Medicine & Medical Imaging SC Neurosciences & Neurology; Radiology, Nuclear Medicine & Medical Imaging GA 123KX UT WOS:000243295900005 PM 17238868 ER PT J AU Mukhophadhyay, S Biswas, S Vindla, S AF Mukhophadhyay, S. Biswas, S. Vindla, S. TI Severe tinnitus in pregnancy, necessitating caesarean delivery SO JOURNAL OF OBSTETRICS AND GYNAECOLOGY LA English DT Article C1 Kingsmill Hosp, Dept Obstet & Gynaecol, Mansfield, PA USA. RP Mukhophadhyay, S (reprint author), 1-3 Welland House,St Anns Close, Lincoln LN2 5RJ, England. EM drsujitmuk@yahoo.co.in CR GURR P, 1993, CLIN OTOLARYNGOL, V18, P294, DOI 10.1111/j.1365-2273.1993.tb00851.x PREECE PE, 1975, BRIT MED J, V4, P498 Shapiro JL, 1999, ACTA OTO-LARYNGOL, V119, P647 Tsunoda K, 1999, J LARYNGOL OTOL, V113, P318 NR 4 TC 2 Z9 2 PU INFORMA HEALTHCARE-TAYLOR & FRANCIS PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON, OXFORSHIRE OX14 4RN, ENGLAND SN 0144-3615 J9 J OBSTET GYNAECOL JI J. Obstet. Gynaecol. PD JAN PY 2007 VL 27 IS 1 BP 81 EP 82 DI 10.1080/01443610601062689 PG 2 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 162RK UT WOS:000246107000022 PM 17365468 ER PT J AU Henry, JA Loovis, C Montero, M Kaelin, C Anselmi, KA Coombs, R Hensley, J James, KE AF Henry, James A. Loovis, Carl Montero, Melissa Kaelin, Christine Anselmi, Kathryn-Anne Coombs, Rebecca Hensley, June James, Kenneth E. TI Randomized clinical trial: Group counseling based on tinnitus retraining therapy SO JOURNAL OF REHABILITATION RESEARCH AND DEVELOPMENT LA English DT Article; Proceedings Paper CT 57th Annual Meeting of the American-Academy-of-Neurology CY APR 09-16, 2005 CL Miami Beach, FL SP Amer Acad Neurol DE auditory; clinical trial; educational counseling; hearing disorders; intervention; outcomes; rehabilitation; tinnitus; tinnitus retraining therapy; Tinnitus Severity Index ID MECHANISMS; MANAGEMENT AB The main component of tinnitus retraining therapy (TRT) is structured counseling. We conducted a randomized clinical trial to test the hypothesis that group educational counseling based on TRT principles would effectively treat veterans who have clinically significant tinnitus. Veterans with clinically significant tinnitus were randomized into one of three groups: educational counseling, traditional support, and no treatment. Subjects in the first two groups attended four 1.5 h group sessions each week. All subjects completed outcome questionnaires at baseline and at 1, 6, and 12 mo. A total of 269 subjects participated: 94 in the educational counseling group, 84 in the traditional support group, and 91 in the no-treatment group. Statistical analyses showed that educational counseling provided significantly more benefit than either traditional support or no treatment, as measured by the Tinnitus Severity Index. Results suggest that group educational counseling can significantly benefit many tinnitus patients and could be integral to a "progressive intervention" approach to tinnitus clinical management. C1 VA Med Ctr, Natl Ctr Rehabil Auditory Res, Dept Vet Affairs, VA Rehabil Res & Dev Serv, Portland, OR USA. Oregon Hlth & Sci Univ, Dept Otolaryngol Head & Neck Surg, Portland, OR 97201 USA. VA Puget Sound Hlth Care Syst, VA Audiol Clin, Seattle, WA USA. Oregon Hlth & Sci Univ, Dept Publ Hlth & Prevent Med, Portland, OR 97201 USA. RP Henry, JA (reprint author), VA Med Ctr, Natl Ctr Rehabil Auditory Res, Dept Vet Affairs, VA Rehabil Res & Dev Serv, Portland, OR USA. EM james.henry@med.va.gov CR Cohen J, 1988, STAT POWER ANAL BEHA, V2nd Coles R. R. A., 1995, MECH TINNITUS, P11 DARBY M, 1998, CLIN PRACTICE GUIDEL Davis A, 2000, TINNITUS HDB, P1 Dobie R, 2004, TINNITUS THEORY MANA, P1 Feussner JR, 1998, J INVEST MED, V46, P264 Henry James A, 2005, Am J Audiol, V14, P21, DOI 10.1044/1059-0889(2005/004) Henry JA, 2005, J REHABIL RES DEV, V42, P95, DOI 10.1682/JRRD.2005.01.0005 Henry JA, 2006, ACTA OTO-LARYNGOL, V126, P64, DOI 10.1080/03655230600895556 Henry JA, 2005, J SPEECH LANG HEAR R, V48, P1204, DOI 10.1044/1092-4388(2005/084) Henry JA, 2004, TINNITUS THEORY MANA, P337 Henry JA, 2006, J AM ACAD AUDIOL, V17, P104, DOI 10.3766/jaaa.17.2.4 Henry JL, 1996, INT TINNITUS J, V2, P9 Jastreboff P, 2000, TINNITUS HDB, P357 Jastreboff P. 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L., 2002, P 7 INT TINN SEM, P226 NR 31 TC 14 Z9 14 PU JOURNAL REHAB RES & DEV PI BALTIMORE PA DEPT OF VETERANS AFFAIRS REHABIL RES & DEVELOP CTR 103 SOUTH GAY STREET, BALTIMORE, MD 21202-4051 USA SN 0748-7711 J9 J REHABIL RES DEV JI J. Rehabil. Res. Dev. PY 2007 VL 44 IS 1 BP 21 EP 31 DI 10.1682/JRRD.2006.02.0018 PG 11 WC Rehabilitation SC Rehabilitation GA 178PG UT WOS:000247232000004 PM 17551855 ER PT J AU Lew, HL Jerger, JF Guillory, SB Henry, JA AF Lew, Henry L. Jerger, James F. Guillory, Sylvia B. Henry, James A. TI Auditory dysfunction in traumatic brain injury SO JOURNAL OF REHABILITATION RESEARCH AND DEVELOPMENT LA English DT Article DE auditory dysfunction; blast-related injury; hearing loss; non-blast-related injury; OIF; rehabilitation; sensorineural hearing loss; TBI; tinnitus; traumatic brain injury ID BLAST INJURIES; CLINICAL-TRIAL; EAR; MANAGEMENT; LONDON; BOMB; IRAQ; CARE; NEED AB Effective communication is essential for successful rehabilitation, especially in patients with traumatic brain injury (TBI). The authors examined the prevalence and characteristics of auditory dysfunction in patients with TBI who were admitted to a Department of Veterans Affairs TBI inpatient unit before and after the onset of Operation Iraqi Freedom (OIF). In order to delineate the characteristics of the auditory manifestations of patients who had sustained blast-related (BR) TBI, we reviewed the medical records of 252 patients with TBI and categorized them according to admission date, either before (Group I, n = 102) or after (Group II, n = 150) the onset of OIF. We subdivided Group 11 into non-blast-related (NBR) and BR TBI; no subjects in Group I had BR TBI. We found that admissions for TBI have increased 47% since the onset of OIF. In Group I, 28% of patients with TBI complained of hearing loss and 11% reported tinnitus. In Group II-NBR (n = 108), 44% complained of hearing loss and 18% reported tinnitus. In Group II-BR (n = 42), 62% complained of hearing loss and 38% reported tinnitus. Sensorineural loss was the most prevalent type of hearing loss in Group II-BR patients. In light of the high prevalence of hearing loss and tinnitus in this growing population of returning soldiers, we need to develop and implement strategies for diagnosis and management of these conditions. C1 [Lew, Henry L.; Guillory, Sylvia B.] Vet Affairs Palo Alto Hlth Care Syst, Phys Med & Rehabil Serv, Palo Alto, CA 94304 USA. [Lew, Henry L.] Stanford Univ, Sch Med, Div Phys Med & Rehabil, Stanford, CA 94305 USA. [Jerger, James F.] Univ Texas Dallas, Sch Behav & Brain Sci, Dallas, TX 75230 USA. [Henry, James A.] VA Med Ctr, Natl Ctr Rehabil Auditory Res, VA Rehabil Res & Dev, Portland, OR USA. [Henry, James A.] Oregon Hlth & Sci Univ, Dept Otolaryngol Head & Neck Surg, Portland, OR 97201 USA. RP Lew, HL (reprint author), Vet Affairs Palo Alto Hlth Care Syst, Phys Med & Rehabil Serv, Palo Alto, CA 94304 USA. 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S., 2006, TINNITUS TREATMENT C Van Campen L E, 1999, J Am Acad Audiol, V10, P231 Vernon J-A, 2000, TINNITUS HDB, P313 WALSH RM, 1995, J ACCID EMERG MED, V12, P194 Warden D, 2006, J HEAD TRAUMA REHAB, V21, P398 Xydakis MS, 2007, NEW ENGL J MED, V357, P830, DOI 10.1056/NEJMc076071 YETISER S, 1993, MIL MED, V158, P803 ZIV M, 1973, MIL MED, V138, P811 NR 46 TC 40 Z9 43 PU JOURNAL REHAB RES & DEV PI BALTIMORE PA DEPT OF VETERANS AFFAIRS REHABIL RES & DEVELOP CTR 103 SOUTH GAY STREET, BALTIMORE, MD 21202-4051 USA SN 0748-7711 J9 J REHABIL RES DEV JI J. Rehabil. Res. Dev. PY 2007 VL 44 IS 7 BP 921 EP 927 DI 10.1682/JRRD.2007.09.0140 PG 7 WC Rehabilitation SC Rehabilitation GA 253NL UT WOS:000252524800005 PM 18075949 ER PT J AU Michel, O Brusis, T AF Michel, O. Brusis, T. TI Compensation for tinnitus in private accident insurance SO LARYNGO-RHINO-OTOLOGIE LA German DT Article DE private accident insurance; compensation; compensation table; invalidity benefit for tinnitus ID TRAUMA; HEAD AB According to the provisions of private accident insurance, mental or psychic reactions are excluded from compensation. Until now, tinnitus was taken as fully psychic and therefore excluded. In two recently published judgments of the Federal Supreme Court in Germany the assessment of tinnitus in private accident insurance and particularly the exclusion clause 2 Abs. 4 AUB 88 has been newly defined. According to this actual jurisdiction the compensation of tinnitus could be possible, when as physical underlying reason a proved harm in the inner ear or the auditory pathway (hearing loss), which can be traced back to the accident according to the rules of causality. This leads to the question how Tinnitus could be compensated without modification of the general terms and conditions of the private accident insurance. A compensating table is proposed, which recognizes the somatic (physical) part of tinnitus and is based on medical and scientific findings of the relation between hearing loss and tinnitus. C1 Univ Cologne, Klin & Poliklin Hals Nasen Ohren Heilkunde, D-50924 Cologne, Germany. Krankenhaus Koln Holweide, Klin HNO Heilkunde Kopf & Halschirurg, Cologne, Germany. RP Michel, O (reprint author), Univ Cologne, Klin & Poliklin Hals Nasen Ohren Heilkunde, Kerpener Str 62, D-50924 Cologne, Germany. EM Michel@uni-koeln.de RI Michel, Olaf/B-3673-2012 OI Michel, Olaf/0000-0003-4289-5693 CR BRUSIS T, 1973, HNO, V21, P55 BURGGRAF H, 1989, HNO, V37, P269 FELDMANN H, 1971, AUDIOLOGY, V10, P138 FOWLER EP, 1965, LARYNGOSCOPE, V75, P1610 GOEBEL G, 1994, HNO, V42, P166 Lockwood AH, 2002, NEW ENGL J MED, V347, P904, DOI 10.1056/NEJMra013395 Michel O, 2006, LARYNGO RHINO OTOL, V85, P204, DOI 10.1055/s-2005-870349 Michel O, 2003, LARYNGO RHINO OTOL, V82, P199, DOI 10.1055/s-2003-38410 Nieschalk M, 1996, HNO, V44, P577, DOI 10.1007/s001060050057 Norena A, 2000, HEARING RES, V149, P24, DOI 10.1016/S0378-5955(00)00158-1 Walter O, 2003, LARYNGO RHINO OTOL, V82, P520 Zenner H.P., 1998, INT TINNITUS J, V4, P109 NR 12 TC 6 Z9 6 PU GEORG THIEME VERLAG KG PI STUTTGART PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY SN 0935-8943 J9 LARYNGO RHINO OTOL JI Laryngo-Rhino-Otol. PD JAN PY 2007 VL 86 IS 1 BP 27 EP 36 DI 10.1055/s-2006-944943 PG 10 WC Otorhinolaryngology SC Otorhinolaryngology GA 125LK UT WOS:000243443200010 PM 17203457 ER PT J AU Hetzler, DG AF Hetzler, Douglas G. TI Osteotome technique for removal of symptomatic ear canal exostoses SO LARYNGOSCOPE LA English DT Review DE exostosis; hyperostosis; surfer's ear; ear canal stenosis; osteotome ID EXTERNAL AUDITORY MEATUS; COLD-WATER; SURFERS EAR; SURGICAL-TREATMENT; PREVALENCE; SURGERY; OPERATIONS; OSTEOMATA; DIVERS AB Objectives/Hypothesis: This study was undertaken to assess a transcanal osteotome technique for removing symptomatic ear canal exostoses. Outcome measures included healing rates and the rate of complications. Study Design: Prospective study in a private practice. Methods: A straight 1-mm osteotome and a curved 1-mm osteotome were used by way of a transcanal approach to incrementally remove obstructive ear canal exostoses. If anterior or superior bone growths were closely approximating the tympanic membrane, they were partially removed with a 1.5 mm cylindrical end- and side-cutting burr. Healing rates were monitored with weekly postoperative visits. Results: Two hundred twenty-one ear canals (140 patients) were consecutively treated with this technique. Healing was achieved at 2 to 8 (average 3.50) weeks, with 90% healed by 4 weeks. There were 4 mobilizations of a full-thickness segment of anterior bony canal wall; 3 exposures of periosteum anterior to the anterior bony wall; 1 tear of the tympanic membrane requiring a tympanoplasty; 18 anterior and 11 posterior tympanic membrane tears that healed spontaneously; 3 instances of sensorineural hearing decrease; 3 cases of new-onset postoperative tinnitus; and 1 instance of postoperative positioning vertigo. There were no lacerations of the tympanic membrane by an osteotome, no facial nerve injuries, no soft tissue stenoses of an ear canal, and no skin grafting of an ear canal. Conclusions. The described technique of using osteotomes transcanal for removal of symptomatic obstructive ear canal exostoses promoted rapid healing and was effective and safe. C1 Palo Alto Med Fdn, Santa Cruz Med Clin Inc, Dept Otolaryngol Head & Neck Surg, Santa Cruz, CA USA. RP Hetzler, DG (reprint author), Santa Cruz Med Clin Inc, Dept Otolaryngol Head & Neck Surg, 2950 Res Pk Dr, Soquel, CA 95073 USA. 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Otorhinolaryngology SC Research & Experimental Medicine; Otorhinolaryngology GA 122ZK UT WOS:000243265900001 PM 17220810 ER PT J AU Haynes, DS O'Malley, M Cohen, S Watford, K Labadie, RF AF Haynes, David S. O'Malley, Matthew Cohen, Seth Watford, Kenneth Labadie, Robert F. TI Intratympanic dexamethasone for sudden sensorineural hearing loss after failure of systemic therapy SO LARYNGOSCOPE LA English DT Article DE sudden sensorineural HL; intratympanic therapy; dexamethasone; steroid perfusion ID ROUND WINDOW MEMBRANE; INNER-EAR; STEROID TREATMENT; GUINEA-PIG; TRANSTYMPANIC STEROIDS; PERILYMPHATIC SCALAE; RADIAL COMMUNICATION; INJECTION; PERFUSION; COCHLEA AB Objective. Intratympanic steroids are increasingly used in the treatment of inner ear disorders, especially in patients with sudden sensorineural hearing loss (SNHL) who have failed systemic therapy. We reviewed our experience with intratympanic steroids in the treatment of patients with sudden SNHL to determine overall success, morbidity, and prognostic factors. Hypothesis. Intratympanic steroids have minimal morbidity and the potential to have a positive effect on hearing recovery in patients with sudden SNHL who have failed systemic therapy. Study Design: The authors conducted a retrospective review. Methods: Patients presenting with sudden SNHL defined as a rapid decline in hearing over 3 days or less affecting 3 or more frequencies by 30 dB or greater who underwent intratympanic steroids therapy (24 mg/mL dexamethasone) were reviewed. Excluded were patients with Meniere disease, retrocochlear disease, autoimmune HL, trauma, fluctuating HL, radiation-induced HL, noise-induced HL, or any other identifiable etiology for sudden HL. Patients who showed signs of fluctuation of hearing after injection were excluded. Pretreatment and posttreatment audiometric evaluations including pure-tone average (PTA) and speech reception threshold (SRT) were analyzed. Patient variables as they related to recovery were studied and included patient age, time to onset of therapy, status of the contralateral ear, presence of diabetes, severity of HL, and presence of associated symptoms (tinnitus, vertigo). A 20-dB gain in PTA or a 20% improvement in SDS was considered significant. Results. Forty patients fit the criteria for inclusion in the study. The mean age of the patients was 54.8 years with a range from 17 to 84 years of age. Overall, 40% (n = 16) showed any improvement in PTA or SDS. Fourteen (35%) men and 26 (65%) women were included. Using the criteria of 20-dB improvement in PTA or 20% improvement in SDS for success, 27.5% (n = 11) showed improvement. The mean number of days from onset of symptoms to intratympanic therapy was 40 days with a range of 7 days to 310 days. A statistically significant difference was noted in those patients who received earlier injection (P =.0008, rank sum test). No patient receiving intratympanic dexamethasone after 36 days recovered hearing using 20-dB PTA decrease or a 20% increase in discrimination as criteria for recovery. Twelve percent (n = 5) of patients in the study had diabetes with 20% recovering after intratympanic dexamethasone (not significantly different from non-diabetics at 28.6%, Fisher exact test, P = 1.0). Comparison to other studies that used differing steroid type, concentration, dosing schedule, inclusion criteria, and criteria for success revealed, in many instances, a similar overall recovery rate. Conclusions. Difficulty in proving efficacy of a single modality is present in all studies on SNHL secondary to multiple treatment protocols, variable rates of recovery, and a high rate of spontaneous recovery. Forty percent of patients showed some improvement in SDS or PTA after treatment failure. When criteria of 20-dB PTA or 20% is considered to define improvement, the recovery rate was 27.5%. Modest improvement is seen with the current protocol of a single intratympanic steroid injection of 24 mg/mL dexamethasone in patients who failed systemic therapy. Dramatic hearing recovery in treatment failures was rarely encountered. No patient showed significant benefit from intratympanic steroids after 36 days when using this protocol for idiopathic sudden SNHL. If patients injected after 6 weeks are xcluded from the study, the improvement rate increases from 26.9% to 39.3%. Earlier intratympanic injection had a significant impact on hearing recovery, although with any therapeutic intervention for sudden SNHL, early success may be attributed to natural history. If we further exclude seven patients treated with intratympanic steroids within 2 weeks of the onset of symptoms (i.e., study only those patients treated with intratympanic dexamethasone between 2 and 6 weeks after onset of symptoms), still, 26% improved by 20 dB or 20% SDS. The recovery rates after initial systemic failure are higher than would be expected in this treatment failure group given our control group (9.1%) and literature review. These findings indicate a positive effect from steroid perfusion in this patient population. C1 Vanderbilt Univ, Med Ctr, Dept Otolaryngol, Otol Grp, Nashville, TN 37232 USA. RP Haynes, DS (reprint author), Vanderbilt Univ, Med Ctr, Dept Otolaryngol, Otol Grp, 1215 21st Ave S,7209 MCE S Tower, Nashville, TN 37232 USA. EM david.haynes@vanderbilt.edu CR Bachmann G, 2001, HNO, V49, P538, DOI 10.1007/s001060170078 Battista RA, 2005, OTOLARYNG HEAD NECK, V132, P902, DOI 10.1016/j.otohns.2005.01.024 BYL FM, 1984, LARYNGOSCOPE, V94, P647 Chandrasekhar SS, 2000, OTOLARYNG HEAD NECK, V122, P521, DOI 10.1016/S0194-5998(00)70094-5 Chandrasekhar SS, 2001, OTOL NEUROTOL, V22, P18, DOI 10.1097/00129492-200101000-00005 Chen CY, 2003, OTOL NEUROTOL, V24, P728, DOI 10.1097/00129492-200309000-00006 Choung YH, 2006, LARYNGOSCOPE, V116, P747, DOI 10.1097/01.mlg.0000205183.29986.f6 Cinamon U, 2001, EUR ARCH OTO-RHINO-L, V258, P477, DOI 10.1007/s004050100366 Dallan I, 2006, ORL J OTO-RHINO-LARY, V68, P247, DOI 10.1159/000093093 El-Hennawi DM, 2005, J LARYNGOL OTOL, V119, P2 Fukui M, 2004, DIABETES RES CLIN PR, V63, P205, DOI 10.1016/j.diabres.2003.09.013 Fukushima M, 2002, ACTA OTO-LARYNGOL, V122, P600, DOI 10.1080/000164802320396268 Fuse T, 2002, ORL J OTO-RHINO-LARY, V64, P6, DOI 10.1159/000049079 Gianoli GJ, 2001, OTOLARYNG HEAD NECK, V125, P142, DOI 10.1067/mhn.2001.117162 Gouveris H, 2005, EUR ARCH OTO-RHINO-L, V262, P131, DOI 10.1007/s00405-004-0772-6 Herr BD, 2005, OTOLARYNG HEAD NECK, V132, P527, DOI 10.1016/j.otohns.2004.09.138 Himeno C, 2002, HEARING RES, V167, P61, DOI 10.1016/S0378-5955(02)00345-3 Ho GM, 2004, LARYNGOSCOPE, V114, P1184 Ito S, 2002, CLIN OTOLARYNGOL, V27, P501, DOI 10.1046/j.1365-2273.2002.00620.x Itoh A, 1991, Acta Otolaryngol Suppl, V481, P617 Jackson LE, 2002, OTOLARYNG CLIN N AM, V35, P639, DOI 10.1016/S0030-6665(02)00023-3 Kopke RD, 2001, OTOL NEUROTOL, V22, P475, DOI 10.1097/00129492-200107000-00011 Lamm K, 1998, HEARING RES, V115, P149, DOI 10.1016/S0378-5955(97)00186-X Lauterman J, 2005, EUR ARCH OTO-RHINO-L, P1 Lefebvre PP, 2002, ACTA OTO-LARYNGOL, V122, P698, DOI 10.1080/003655402/000028037 LIN DW, 1997, OTOLARYNGOL HEAD NEC, V117, P1 MATTOX DE, 1977, ANN OTO RHINOL LARYN, V86, P463 MOSKOWITZ D, 1984, LARYNGOSCOPE, V94, P664 Nagura M, 1999, EUR J PHARMACOL, V366, P47, DOI 10.1016/S0014-2999(98)00881-4 Nordang L, 2003, OTOL NEUROTOL, V24, P339, DOI 10.1097/00129492-200303000-00034 Parnes LS, 1999, LARYNGOSCOPE, V109, P1, DOI 10.1097/00005537-199907001-00001 Plontke S, 2002, Acta Otorhinolaryngol Belg, V56, P369 RAREY KE, 1989, HEARING RES, V41, P217, DOI 10.1016/0378-5955(89)90013-0 SAIJO S, 1984, ACTA OTO-LARYNGOL, V97, P593, DOI 10.3109/00016488409132937 Salt AN, 2001, HEARING RES, V154, P88, DOI 10.1016/S0378-5955(01)00223-4 SALT AN, 1991, HEARING RES, V56, P37, DOI 10.1016/0378-5955(91)90151-X SALT AN, 1991, HEARING RES, V56, P29, DOI 10.1016/0378-5955(91)90150-8 SHAIA FT, 1976, LARYNGOSCOPE, V86, P389, DOI 10.1288/00005537-197603000-00008 Shirwany NA, 1998, AM J OTOL, V19, P230 Silverstein H, 1996, Ear Nose Throat J, V75, P468 Slattery WH, 2005, OTOLARYNG HEAD NECK, V133, P251, DOI 10.1016/j.otohns.2005.05.015 Slattery WH, 2005, OTOLARYNG HEAD NECK, V132, P5, DOI 10.1016/j.otohns.2004.09.072 Sone M, 2003, EUR J PHARMACOL, V482, P313, DOI 10.1016/j.ejphar.2003.09.051 Spandow O, 1988, Acta Otolaryngol Suppl, V455, P90, DOI 10.3109/00016488809125066 STOCKROOS RJ, 1998, AM J OTOL, V19, P447 Tabuchi K, 2003, HEARING RES, V180, P51, DOI 10.1016/S0378-5955(03)00078-9 Trune DR, 1999, HEARING RES, V137, P160, DOI 10.1016/S0378-5955(99)00147-1 WILSON WR, 1980, ARCH OTOLARYNGOL, V106, P772 Xenellis J, 2006, OTOLARYNG HEAD NECK, V134, P940, DOI 10.1016/j.otohns.2005.03.081 Yang GSY, 2000, AM J OTOL, V21, P499 YAO XF, 1995, HEARING RES, V86, P183, DOI 10.1016/0378-5955(95)00069-G Yilmaz I, 2005, AM J OTOLARYNG, V26, P113, DOI 10.1016/j.amjoto.2004.11.001 Zadeh MH, 2003, OTOLARYNG HEAD NECK, V128, P92, DOI 10.1067/mhn.2003.50 NR 53 TC 105 Z9 122 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0023-852X J9 LARYNGOSCOPE JI Laryngoscope PD JAN PY 2007 VL 117 IS 1 BP 3 EP 15 DI 10.1097/01.mlg.0000245058.11866.15 PG 13 WC Medicine, Research & Experimental; Otorhinolaryngology SC Research & Experimental Medicine; Otorhinolaryngology GA 122AU UT WOS:000243198900002 PM 17202923 ER PT J AU Gomides, APM do Rosario, EJ Borges, HM Gomides, HHM de Padua, PM Sampaio-Barros, PD AF Gomides, A. P. M. do Rosario, E. J. Borges, H. M. Gomides, H. H. M. de Padua, P. M. Sampaio-Barros, P. D. TI Sensorineural dysacusis in patients with systemic lupus erythematosus SO LUPUS LA English DT Article DE hearing loss; sensorineural dysacusis; systemic lupus erythematosus ID HEARING-LOSS; ANTIPHOSPHOLIPID SYNDROME; EAR DISEASE; MANIFESTATIONS; GRANULOMATOSIS; ANTIBODIES; DISORDERS AB The objective of this study was to establish the frequency of involvement of the auditory apparatus in 45 female patients with systemic lupus erythematosus (SLE) submitted to general clinical and laboratory assessments, and tone and vocal audiometry accompanied by a questionnaire evaluating auditory symptoms. The control group consisted of 45 healthy women, matched by age. Auditory symptoms were present in 25 (55.5%) patients, with a diagnosis of sensorineural hearing loss in seven (15.60%) patients. A significant correlation with hypoacusis (P < 0.001), ear fullness (P = 0.012) and tinnitus (P = 0.017) was observed in patients with hearing loss. None of the clinical or laboratory parameters showed an association with sensorineural hearing loss. In the control group, three women (6.7%) presented audiometric alterations, including two with altered tympanometry results and one with mild sensorineural hearing loss. In conclusion, an adequate investigation of auditory symptoms is important during the follow-up of patients with SLE, since manifestations of the auditory apparatus and sensorineural hearing loss can affect a significant proportion of patients. C1 [Gomides, A. P. M.; do Rosario, E. J.; de Padua, P. M.] Audiol Sect, Rheumatol Unit, Santa Casa De Belo Horiz, MG, Brazil. [Borges, H. M.] Audiol Sect, Otorhinolaryngol Unit, Santa Casa De Belo Horiz, MG, Brazil. [Sampaio-Barros, P. D.] Univ Estadual Campinas, Rheumatol Unit, Campinas, SP, Brazil. RP Gomides, APM (reprint author), Av R Afonso Pena,327 Centro, BR-38610000 Unai, MG, Brazil. EM anapingomides@terra.com.br RI SAMPAIO BARROS, PERCIVAL/B-3298-2014 CR ANDONOPOULOS AP, 1995, CLIN EXP RHEUMATOL, V13, P137 ARNOLD W, 1984, LARYNG RHINOL OTOL V, V63, P428, DOI 10.1055/s-2007-1008327 ATRA E, 1983, BRAZ J RHEUMATOL, V23, P203 BARNA BP, 1988, CLIN LAB MED, V8, P385 BOMBARDIER C, 1992, ARTHRITIS RHEUM, V35, P630, DOI 10.1002/art.1780350606 BOWMAN CA, 1986, OTOLARYNG HEAD NECK, V94, P197 CALDARELLI DD, 1986, AM J OTOL, V7, P210 CECATTO SB, 2004, REV BRAS OTORHINOLAR, V70, P1 Compadretti GC, 2005, ANN OTO RHINOL LARYN, V114, P214 HISASHI K, 1993, AM J OTOLARYNG, V14, P275, DOI 10.1016/0196-0709(93)90075-I Jenkins H A, 1981, Am J Otolaryngol, V2, P99, DOI 10.1016/S0196-0709(81)80026-9 Kastanioudakis I, 2002, J LARYNGOL OTOL, V116, P103 KORNBLUT AD, 1982, LARYNGOSCOPE, V92, P713, DOI 10.1288/00005537-198207000-00001 MAGARO M, 1990, CLIN EXP RHEUMATOL, V8, P487 MCDONALD TJ, 1983, LARYNGOSCOPE, V93, P220 Naarendorp M, 1998, J RHEUMATOL, V25, P589 Papadimitraki ED, 2004, CLIN EXP RHEUMATOL, V22, P485 Rahman MU, 2001, CURR OPIN RHEUMATOL, V13, P184, DOI 10.1097/00002281-200105000-00006 SILMAN S, 1991, AUDITORY DIAGNOSIS P, P253 Sone M, 1999, ANN OTO RHINOL LARYN, V108, P338 Stone JH, 2000, CURR OPIN RHEUMATOL, V12, P32, DOI 10.1097/00002281-200001000-00006 TAN EM, 1982, ARTHRITIS RHEUM, V25, P1271, DOI 10.1002/art.1780251101 VYSE T, 1994, J LARYNGOL OTOL, V108, P57 NR 23 TC 11 Z9 12 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 0961-2033 J9 LUPUS JI Lupus PY 2007 VL 16 IS 12 BP 987 EP 990 DI 10.1177/0961203307084160 PG 4 WC Rheumatology SC Rheumatology GA 249BA UT WOS:000252200400009 PM 18042593 ER PT J AU Sastry, A Al-Waa, AM Zaman, S AF Sastry, Anand Al-Waa, Ahmad Munzer Zaman, Salman TI Magnetic resonance imaging for acoustic neuromas SO MEDITERRANEAN JOURNAL OF OTOLOGY LA English DT Article; Proceedings Paper CT 8th International Congress of the Mediterranean-Society-of-Otology-and-Audiology CY MAY 17-21, 2006 CL Dubrovnik, CROATIA SP Mediterranean Soc Otol & Audiol AB OBJECTIVE: The aim of this retrospective study was to evaluate the use of magnetic resonance imaging (MRI) of the internal auditory meatus (IAM) in identifying acoustic neuromas. MATERIALS AND METHODS: Retrospective case review involving 335 patients who presented to the Department of Otolaryngology in Leighton Hospital, United Kingdom for the treatment of various otologic symptoms. RESULTS: In 3 of the 335 patients evaluated, an MRI scan revealed an acoustic neuroma in the cerebellopontine (CP) angle. MRI scans of 326 patients did not show a pathologic condition in the CP angle. Six patients did not undergo MRI because of various contraindications, 2 patients presented with both a progressive asymmetrical sensorineural hearing loss of > 15 dB and tinnitus, and 1 patient presented with a unilateral hearing loss, tinnitus, and vertigo (all of which were sudden in onset). None of the patients with NIHL (10 dB at 4 kHz) or with vertigo alone had a pathologic condition of the CP angle. Most of study subjects had been exposed to loud noise in the past. CONCLUSIONS: Magnetic resonance imaging of the internal auditory meatus should be considered for patients in whom clinical examination does not reveal the cause of a unilateral or asymmetrical hearing loss of > 15 dB and concomitant tinnitus. We found that hearing loss was more significant if it was progressive or of sudden onset. Patients with noise-induced hearing loss (10 dB at 4 kHz), vertigo without hearing loss (a disorder unlikely to result from an acoustic neuroma), or asymmetrical hearing loss due to Eustachian tube dysfunction were unlikely to have an acoustic neuroma and therefore did not require magnetic resonance imaging. Evaluation with pure tone audiometry should always be considered before magnetic resonance imaging of the internal auditory meatus is performed. The results of magnetic resonance imaging should be compared with those of previous pure tone audiometric studies, and any change in frequency thresholds should be noted. This approach prevents the unnecessary imaging of healthy patients and decreases both the radiology staff workload and the cost of patient care. RP Sastry, A (reprint author), Room 23,139 Beacon Bldg,London Rd, Liverpool L3 8JA, Merseyside, England. EM dranandsastry@rediffmail.com CR Annesley-Williams DJ, 2001, J LARYNGOL OTOL, V115, P14 LANSER MJ, 1992, OTOLARYNG CLIN N AM, V25, P995 NR 2 TC 1 Z9 1 PU MEDITERRANEAN SOC OTOLOGY & AUDIOLOGY PI ANKARA PA SELANIK CADDESI 48, 3 KIZILAY, ANKARA, 00000, TURKEY SN 1305-5267 J9 MEDITERR J OTOL JI Mediterr. J. Otol. PY 2007 VL 3 IS 3 BP 117 EP 119 PG 3 WC Otorhinolaryngology SC Otorhinolaryngology GA 281WU UT WOS:000254530400001 ER PT J AU Moriya, M Itokawa, H Fujimoto, M Noda, M Nagashima, G Asai, J Suzuki, R Fujimoto, T AF Moriya, Masao Itokawa, Hiroshi Fujimoto, Michio Noda, Masayuki Nagashima, Goro Asai, Jun-ichiro Suzuki, Ryuta Fujimoto, Tsukasa TI Spontaneous closure of dural arteriovenous fistula after performing diagnostic angiography SO NEUROLOGICAL SURGERY LA Japanese DT Article DE dural arteriovenous fistula; spontaneous closure; angiography; thrombosis ID SPONTANEOUS REGRESSION; MALFORMATION; FOSSA; SINUSES; LESION AB The pathogenesis and clinical treatment of dural arteriovenous fistulas (DAVF) has been well established. However, only 15 cases of spontaneous closure of DAVFs have been reported. We describe a case of spontaneous closure of a DAVF. A 60-year-old male presented with pulsatile tinnitus. Selective cerebral angiography revealed a left posterior DAVF fed by the left occipital artery and the middle meningeal artery, which drained into the left transverse sinus and sigmoid sinus. Following the initial angiography, the patient exhibited vomiting with transient disorientation and amnesia. These symptoms, along with the tinnitus, disappeared by the following day. Seven days after the initial angiography, a second angiography was performed that revealed the complete disappearance of the DAVF. Previous reports have described a long period of closure for DAVFs following initial diagnosis, Possible mechanisms for spontaneous closure of DAVFs include the development of scar tissue or a sinus thrombosis that leads to occlusion of the DAVE In this case, the DAVF closure may have been due to a sinus thrombosis induced by sinus stenosis, since occlusion of the draining sinuses coincided with the spontaneous closure of the DAVF. In cases of non-traumatic DAVF without cortical venous reflex that do not present severe symptoms, a prudent course of treatment is necessary since there is a chance of spontaneous closure of the DAVF occuring. C1 Showa Univ, Fujigaoka Hosp, Dept Neurosurg, Aoba Ku, Yokohama, Kanagawa 2278501, Japan. RP Moriya, M (reprint author), Showa Univ, Fujigaoka Hosp, Dept Neurosurg, Aoba Ku, 1-30 Fujigaoka, Yokohama, Kanagawa 2278501, Japan. EM ns-mmoriya@showa-university-fujigaoka.gr.jp CR CHAUDHARY MY, 1982, AM J NEURORADIOL, V3, P13 COGNARD C, 1995, RADIOLOGY, V194, P671 DIJK JMC, 2002, STROKE, V33, P1233 Dyck P, 1977, Neurosurgery, V1, P287 ENDO S, 1979, J NEUROSURG, V51, P715, DOI 10.3171/jns.1979.51.5.0715 HALBACH VV, 1987, RADIOLOGY, V163, P443 HANSEN JH, 1976, J NEUROSURG, V45, P338, DOI 10.3171/jns.1976.45.3.0338 KATAOKA K, 1984, J NEUROSURG, V60, P1275, DOI 10.3171/jns.1984.60.6.1275 KUTLUK K, 1991, NEUROCHIRURGIA, V34, P144 LANDMAN JA, 1985, AM J NEURORADIOL, V6, P448 Luciani A, 2001, AM J NEURORADIOL, V22, P992 Magidson M A, 1976, Surg Neurol, V6, P107 NEWTON T, 1969, RADIOLOGY, V90, P27 OLUTOLA PS, 1983, NEUROSURGERY, V12, P687 REUL J, 1993, NEURORADIOLOGY, V35, P388 ROHR J, 1985, REV NEUROL, V141, P240 Satomi J, 2002, J NEUROSURG, V97, P767, DOI 10.3171/jns.2002.97.4.0767 1992, NUROSURGEONS, V11, P106 NR 18 TC 6 Z9 6 PU IGAKU-SHOIN LTD PI TOKYO PA 5-24-3 HONGO BUNKYO-KU, TOKYO, 113 91, JAPAN SN 0301-2603 J9 NEUROL SURG TOKYO JI Neurol. Surg. PD JAN PY 2007 VL 35 IS 1 BP 65 EP 70 PG 6 WC Neurosciences; Surgery SC Neurosciences & Neurology; Surgery GA 135KQ UT WOS:000244152900009 PM 17228770 ER PT J AU Tirakotai, W Benes, L Kappus, C Sure, U Farhoud, A Bien, S Bertalanffy, H AF Tirakotai, W. Benes, L. Kappus, C. Sure, U. Farhoud, A. Bien, S. Bertalanffy, H. TI Surgical management of dural arteriovenous fistulas with transosseous arterial feeders involving the jugular bulb SO NEUROSURGICAL REVIEW LA English DT Article DE dural arteriovenous fistula; intraosseous DAVFs; jugular bulb; occipital condyle; transcondylar approach; transosseous arterial feeder ID PULSATILE TINNITUS; SKULL BASE; STEREOTACTIC RADIOSURGERY; TRANSCONDYLAR APPROACH; SIGMOID SINUSES; ACQUIRED LESION; MALFORMATIONS; TRANSVERSE; CLASSIFICATION; EMBOLIZATION AB Dural arteriovenous fistulas located in the vicinity of the jugular foramen are complex vascular malformations and belong to the most challenging skull base lesions to treat. The authors comprehensively analyze multiple features in a series of dural arteriovenous fistulas with transosseous arterial feeders involving the jugular bulb. Four patients who underwent surgery via the transcondylar approach to treat dural arteriovenous fistulas around the jugular foramen were retrospectively reviewed. Previously, endovascular treatment was attempted in all patients. The success of the surgical treatment was examined with postoperative angiography. Complete obliteration of the dural arteriovenous fistulas (DAVFs) was achieved in three patients, and significant flow reduction in one individual. All patients had a good postoperative outcome, and only one experienced mild hypoglossal nerve palsy. Despite extensive bone drilling, an occipitocervical fusion was necessary in only one patient with bilateral lesions. The use of an individually tailored transcondylar approach to treat dural arteriovenous fistulas at the region of the jugular foramen is most effective. This approach allows for complete obliteration of the connecting arterial feeders, and removal of bony structures containing pathological vessels. C1 Univ Hosp, Dept Neurosurg, D-35043 Marburg, Germany. Univ Hosp, Dept Neuroradiol, D-35043 Marburg, Germany. RP Tirakotai, W (reprint author), Univ Hosp, Dept Neurosurg, D-35043 Marburg, Germany. EM srwtr@yahoo.com CR BABU RP, 1994, J NEUROSURG, V81, P49, DOI 10.3171/jns.1994.81.1.0049 BERTALANFFY H, 2000, CRANIAL BASE SURG, P237 Bertalanffy H, 2002, OPER TECH NEUROSURG, V5, P11, DOI 10.1053/otns.2002.00000 Bertalanffy H, 1996, Acta Neurochir Suppl, V65, P82 BERTALANFFY H, 1991, NEUROSURGERY, V29, P815 Brown RD, 2005, MAYO CLIN PROC, V80, P269 CHAUDHARY MY, 1982, AM J NEURORADIOL, V3, P13 Chen CJ, 2001, J COMPUT ASSIST TOMO, V25, P133, DOI 10.1097/00004728-200101000-00025 COGNARD C, 1995, RADIOLOGY, V194, P671 DAVIES MA, 1997, INTERV NEURORADIOL, V3, P299 Davies MA, 1996, J NEUROSURG, V85, P830, DOI 10.3171/jns.1996.85.5.0830 DIETZ RR, 1994, AM J NEURORADIOL, V15, P879 Dion J, 1993, DURAL ARTERIOVENOUS, P1 Ernst R, 1999, AM J NEURORADIOL, V20, P2016 Friedman JA, 2001, J NEUROSURG, V94, P886, DOI 10.3171/jns.2001.94.6.0886 George B, 1995, SURG NEUROL, V44, P279, DOI 10.1016/0090-3019(95)00174-3 HASSO AN, 1994, AM J NEURORADIOL, V15, P890 HOUSER OW, 1979, MAYO CLIN PROC, V54, P651 Kattner DA, 2002, NEUROSURGERY, V50, P1156 Kattner KA, 2004, NEUROL INDIA, V52, P325 Kim MS, 2002, J NEUROSURG, V96, P952, DOI 10.3171/jns.2002.96.5.0952 Kim MS, 2002, J CLIN NEUROSCI, V9, P147, DOI 10.1054/jocn.2001.1029 Koenigsberg RA, 1996, CLIN IMAG, V20, P95, DOI 10.1016/0899-7071(94)00084-0 Lawton MT, 1997, J NEUROSURG, V87, P267, DOI 10.3171/jns.1997.87.2.0267 Link MJ, 1996, J NEUROSURG, V84, P804, DOI 10.3171/jns.1996.84.5.0804 MALIK GM, 1994, J NEUROSURG, V81, P620, DOI 10.3171/jns.1994.81.4.0620 NEWTON TH, 1969, RADIOLOGY, V93, P1071 OlteanuNerbe V, 1997, ACTA NEUROCHIR, V139, P307, DOI 10.1007/BF01808826 OSBORN AG, 1999, DIAGNOSTIC CEREBRAL, P300 PIEROT L, 1992, AM J NEURORADIOL, V13, P315 PISKE RL, 1988, NEURORADIOLOGY, V30, P426 ROY D, 1993, J OTOLARYNGOL, V22, P409 Shin M, 2000, NEUROSURGERY, V46, P730, DOI 10.1097/00006123-200003000-00039 Steiger HJ, 2005, ACT NEUR S, V94, P115 Sure U, 2002, NEUROL MED-CHIR, V42, P458, DOI 10.2176/nmc.42.458 Terada T, 1996, ACTA NEUROCHIR, V138, P877, DOI 10.1007/BF01411267 Tirakotai W, 2004, CHINESE MED J-PEKING, V117, P1815 Tirakotai W, 2005, CLIN NEUROL NEUROSUR, V107, P455, DOI 10.1016/j.clineuo.2004.11.014 Uranishi R, 1999, J NEUROSURG, V91, P781, DOI 10.3171/jns.1999.91.5.0781 NR 39 TC 8 Z9 8 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013 USA SN 0344-5607 J9 NEUROSURG REV JI Neurosurg. Rev. PD JAN PY 2007 VL 30 IS 1 BP 40 EP 48 DI 10.1007/s10143-006-0056-2 PG 9 WC Clinical Neurology; Surgery SC Neurosciences & Neurology; Surgery GA 111FM UT WOS:000242436800011 PM 17109181 ER PT J AU Huang, CY Lee, HH Chung, KC Chen, HC Shen, YJ Wu, JL AF Huang, Chii-Yuan Lee, Heng-Huei Chung, Kao-Chi Chen, Hsiao-Chuan Shen, Yung-Ji Wu, Jiunn-Liang TI Relationships among speech perception, self-rated tinnitus loudness and disability in tinnitus patients with normal pure-tone thresholds of hearing SO ORL-JOURNAL FOR OTO-RHINO-LARYNGOLOGY AND ITS RELATED SPECIALTIES LA English DT Article DE tinnitus loudness; speech perception; tinnitus disability ID HANDICAP INVENTORY; SEVERITY; SYSTEM AB Exactly how speech perception and tinnitus perception are related remains unclear. This study investigated how tinnitus alone affects speech perception and the relationship between speech perception, tinnitus loudness, and tinnitus disability. The Mandarin Speech Perception in Noise Test (MSPIN), Tinnitus Loudness Scaling (TLS), and Tinnitus Handicap Inventory (THI) were utilized to assess 20 tinnitus patients with normal hearing. The tinnitus group had a significantly lower MSPIN score than the control group (p < 0.01). TLS and THI scores were strongly correlated (r(2) : 0.534 similar to 0.627, p < 0.05). Correlations between MSPIN and TLS or THI scores were not significant. Tinnitus loudness correlated well with tinnitus-related disability. Neither tinnitus loudness nor disability was strongly correlated with speech perception. In noisy environments, tinnitus sufferers had significantly poorer ability to recognize speech than control subjects. C1 Natl Cheng Kung Univ, Coll Med, Dept Otolaryngol, Tainan 704, Taiwan. Natl Cheng Kung Univ, Inst Biomed Engn, Tainan 704, Taiwan. Natl Kaohsiung Normal Univ, Grad Inst Audiol & Speech Therapy, Kaohsiung, Taiwan. RP Wu, JL (reprint author), Natl Cheng Kung Univ, Coll Med, Dept Otolaryngol, Tainan 704, Taiwan. EM entah@mail.ncku.edu.tw CR Andersson G, 2003, AURIS NASUS LARYNX, V30, P129, DOI 10.1016/S0385-8146(03)00008-7 BARNEA G, 1990, AUDIOLOGY, V29, P36 Folmer RL, 1999, OTOLARYNG HEAD NECK, V121, P48, DOI 10.1016/S0194-5998(99)70123-3 Heller AJ, 2003, OTOLARYNG CLIN N AM, V36, P239, DOI 10.1016/S0030-6665(02)00160-3 Henry J A, 2000, J Am Acad Audiol, V11, P138 Huang CY, 2006, ORL J OTO-RHINO-LARY, V68, P110, DOI 10.1159/000091213 KALIKOW DN, 1977, J ACOUST SOC AM, V61, P1337, DOI 10.1121/1.381436 Lockwood AH, 1998, NEUROLOGY, V50, P114 Matsushima J, 1997, Acta Otolaryngol Suppl, V532, P115 MEIKLE MB, 1984, OTOLARYNG HEAD NECK, V92, P689 Newman CW, 1996, ARCH OTOLARYNGOL, V122, P143 NEWMAN CW, 1994, AUDIOLOGY, V33, P47 Reyes SA, 2002, HEARING RES, V171, P43, DOI 10.1016/S0378-5955(02)00346-5 Sirimanna T., 1996, J AUDIOL MED, V5, P38 STOUFFER JL, 1990, J SPEECH HEAR DISORD, V55, P439 SULLIVAN MD, 1988, GEN HOSP PSYCHIAT, V10, P285, DOI 10.1016/0163-8343(88)90037-0 TSAI CH, 2002, B SPEC ED, V23, P121 TYLER RS, 1983, J SPEECH HEAR DISORD, V48, P150 Zachariae R, 2000, SCAND AUDIOL, V29, P37, DOI 10.1080/010503900424589 NR 19 TC 3 Z9 5 PU KARGER PI BASEL PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND SN 0301-1569 J9 ORL J OTO-RHINO-LARY JI ORL-J. Oto-Rhino-Laryngol. Relat. Spec. PY 2007 VL 69 IS 1 BP 25 EP 29 DI 10.1159/000096713 PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA 117BN UT WOS:000242847600004 PM 17085949 ER PT J AU Porubsky, C Stiegler, P Matzi, V Lipp, C Kontaxis, A Klemen, H Walch, C Smolle-Juttner, F AF Porubsky, C. Stiegler, P. Matzi, V. Lipp, C. Kontaxis, A. Klemen, H. Walch, C. Smolle-Juettner, F. TI Hyperbaric oxygen in tinnitus: Influence of psychological factors on treatment results? SO ORL-JOURNAL FOR OTO-RHINO-LARYNGOLOGY AND ITS RELATED SPECIALTIES LA English DT Article DE hyperbaric oxygen; tinnitus, psychological factors ID INNER-EAR; HEARING-LOSS; THERAPY AB Introduction: The standard treatment of subjective tinnitus hardly reaches the level of placebo controls. Though the effectiveness of hyperbaric oxygenation (HBO) for subjective tinnitus has never been objectified, it is still advocated by some institutions. We analyzed the effectiveness of hyperbaric oxygen treatment in the context of accompanying factors. Patients and Methods: We randomized 360 patients suffering from tinnitus into 2 HBO treatment protocols (group A: 2.2 bar for 60 min bottom time and group B: 2.5 bar for 60 min bottom time once a day for 15 days). All patients were asked to fill in a questionnaire (social and medical history, tinnitus characteristics, pre-HBO duration of tinnitus, prior therapy, pretreatment expectation, accompanying symptoms). A subjective assessment of the therapeutic effect was obtained. Results: Twelve patients (3.3%) experienced complete remission of tinnitus, in 122 (33.9) the intensity lessened, and 44 (12.2%) had a subjectively agreeable change of noise characteristics. No change was found in 157 cases (43.6%) and 25 (6.9%) experienced deterioration. There was no statistically significant difference between groups A and B (p > 0.05). Out of 68 patients with a positive expectation of HBO effects, 60.3% stated that the tinnitus had improved whereas only 47.2 and 19%, respectively, out of patients who underwent therapy with an indifferent (n = 271) or negative expectation (n = 21) reported an improvement. The influence of subjective expectation on the outcome was statistically significant (p < 0.05). Conclusion: The therapeutic effects of HBO on subjective tinnitus may be substantially influenced by psychological mechanisms. Copyright (c) 2007 S. Karger AG, Basel. C1 Univ Med, Div Thorac & Hyperbar Surg, AT-8036 Graz, Austria. Univ Med, Dept Transplantat Surg, Dept Surg, AT-8036 Graz, Austria. Univ Med, Dept ENT, AT-8036 Graz, Austria. RP Porubsky, C (reprint author), Univ Med, Div Thorac & Hyperbar Surg, Auenbruggerpl 29, AT-8036 Graz, Austria. EM christian.porubsky@klinikum-graz.at CR Bernhardt O, 2004, J ORAL REHABIL, V31, P311, DOI 10.1046/j.1365-2842.2003.01249.x Biesinger E, 1998, HNO, V46, P157, DOI 10.1007/s001060050215 BOCK KH, 1994, PRAXIS INTENSIVBEHAN, P415 Feldmeier J, 2003, UNDERSEA HYPERBAR M, V30, P1 FISH U, 1976, ACTA OTOLARYNGOL STO, V81, P278 Hesse G, 1999, HNO, V47, P658, DOI 10.1007/s001060050442 JASTREBOFF PJ, 1990, NEUROSCI RES, V8, P221, DOI 10.1016/0168-0102(90)90031-9 Jastreboff P J, 2000, J Am Acad Audiol, V11, P162 JASTREBOFF PJ, 1998, TINNITUS HYPERACUSIS, P198 Kroner-Herwig B, 2003, J PSYCHOSOM RES, V54, P381, DOI 10.1016/S0022-3999(02)00400-2 Kuokkanen J, 2000, Acta Otolaryngol Suppl, V543, P132 LAMM H, 1979, ARCH OHREN NASEN KEH, V222, P145, DOI 10.1007/BF00469754 LAMM H, 1995, OTO RHINO LARYN NOVA, V5, P161 Lamm K, 1999, ANN NY ACAD SCI, V884, P233, DOI 10.1111/j.1749-6632.1999.tb08645.x LAMM K, 1995, OTO RHINO LARYN NOVA, V5, P153 Lewis J E, 2002, J Am Acad Audiol, V13, P339 Lockwood AH, 2002, NEW ENGL J MED, V347, P904, DOI 10.1056/NEJMra013395 Mirz F, 1999, CLIN OTOLARYNGOL, V24, P346, DOI 10.1046/j.1365-2273.1999.00277.x Poshnoi Luba, 2004, Harefuah, V143, P106 Sahley TL, 2001, HEARING RES, V152, P43, DOI 10.1016/S0378-5955(00)00235-5 NR 20 TC 2 Z9 2 PU KARGER PI BASEL PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND SN 0301-1569 J9 ORL J OTO-RHINO-LARY JI ORL-J. Oto-Rhino-Laryngol. Relat. Spec. PY 2007 VL 69 IS 2 BP 107 EP 112 DI 10.1159/000097841 PG 6 WC Otorhinolaryngology SC Otorhinolaryngology GA 117BO UT WOS:000242847700007 PM 17159373 ER PT J AU Yimtae, K Srirompotong, S Lertsukprasert, K AF Yimtae, Kwanchanok Srirompotong, Somchai Lertsukprasert, Krisna TI Otosyphilis: A review of 85 cases SO OTOLARYNGOLOGY-HEAD AND NECK SURGERY LA English DT Review ID LATE SYPHILIS; AIDS AB OBJECTIVE: To review the clinical manifestations and the follow-up hearing results of the treatment modalities in the patients with otosyphilis. STUDY DESIGN AND SETTINGS: A retrospective review between 1984 and 2000 at a university hospital. Patients who presented with cochleovestibular symptoms and were confirmed seropositive for specific treponemal tests were included. Excluded were patients older than 70, or who had other identified causes of cochleovestibular symptoms. RESULTS: Subjects included 56 males and 29 females with an average age of 59.5 years (range, 40 to 70). Common presenting symptoms included hearing loss (90.6%), tinnitus (72.9%), and vertigo (52.9%). The cerebrospinal fluid analysis was positive in 5.4%. The overall respective hearing results in the short- and long-term follow-up were improved or stable in 93.4% and 83.3% of patients. Even though adding steroids and neurosyphilis regimens tended to improve and stabilize hearing, the results were not statistically significant among treatment modalities. CONCLUSION: Further study about hearing outcomes among treatment modalities is suggested. (c) 2007 American Academy of Otolaryngology-Head and Neck Surgery Foundation. All rights reserved. C1 Khon Kaen Univ, Fac Med, Dept Otolaryngol, Neurootol Unit, Khon Kaen 40002, Thailand. Mahidol Univ, Ramathibodi Hosp, Fac Med, Bangkok 10700, Thailand. RP Yimtae, K (reprint author), Khon Kaen Univ, Fac Med, Dept Otolaryngol, Neurootol Unit, Khon Kaen 40002, Thailand. EM kwayim@kku.ac.th RI Khon Kaen University, Faculty of Medicine/A-3133-2009 CR BECKER GD, 1979, LARYNGOSCOPE, V89, P1135 *CDCP, 1998, MMWR-MORBID MORTAL W, V47, P28 CHAN YM, 1995, J LARYNGOL OTOL, V109, P719 DOBBIN JM, 1983, LARYNGOSCOPE, V93, P1540, DOI 10.1288/00005537-198312000-00003 GLIECH LL, 1992, LARYNGOSCOPE, V102, P1255 HUGES GB, 1986, ANN OTOL RHONOL LARY, V95, P250 MORRISON AW, 1992, GENITOURIN MED, V68, P420 SCHRODER M, 1983, HNO, V31, P117 SCHUKNECHT HF, 1993, PATHOLOGY EAR, P247 Singh AE, 1999, CLIN MICROBIOL REV, V12, P187 SMITH ME, 1989, LARYNGOSCOPE, V99, P365, DOI 10.1288/00005537-198904000-00001 STECKELBERG JM, 1984, LARYNGOSCOPE, V94, P753 Tramont EC, 1995, CLIN INFECT DIS, V21, P1361 WIESEL J, 1985, ARCH INTERN MED, V145, P465, DOI 10.1001/archinte.145.3.465 NR 14 TC 8 Z9 9 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0194-5998 J9 OTOLARYNG HEAD NECK JI Otolaryngol. Head Neck Surg. PD JAN PY 2007 VL 136 IS 1 BP 67 EP 71 DI 10.1016/j.otohns.2006.08.026 PG 5 WC Otorhinolaryngology; Surgery SC Otorhinolaryngology; Surgery GA 125KT UT WOS:000243441500015 PM 17210336 ER PT J AU Khan, M Gross, J Haupt, H Jainz, A Niklowitz, P Scherer, H Schmidt, FP Klapp, BF Reisshauer, A Mazurek, B AF Khan, Martin Gross, Johann Haupt, Heidemarie Jainz, Annett Niklowitz, Petra Scherer, Hans Schmidt, Frank-Peter Klapp, Burghard F. Reisshauer, Anett Mazurek, Birgit TI A pilot clinical trial of the effects of coenzyme Q10 on chronic tinnitus aurium SO OTOLARYNGOLOGY-HEAD AND NECK SURGERY LA English DT Article ID OXIDATIVE STRESS; PARKINSONS-DISEASE; Q(10); SUPPLEMENTATION; SUFFERERS; PLASMA; DAMAGE; BRAIN; MODEL AB OBJECTIVE: To determine the short-term effects of coenzyme Q10 (CoQ10) on the antioxidative status and tinnitus expression in patients with chronic tinnitus aurium. STUDY DESIGN: A 16-week prospective nonrandomized clinical trial (n = 20). Tinnitus and Short Form-36 Questionnaires (TQ/SF-36) were evaluated together with the plasma concentrations of CoQ10, malondialdehyde, and the total antioxidant status. RESULTS: The mean plasma CoQ10 concentration rose under external CoQ10 supply and remained elevated after medication stopped without overall effects on the tinnitus score. However, in a subgroup of 7 patients with low initial plasma CoQ10 concentration and significant increase in the plasma CoQ10 level, a clear decrease in the TQ score was observed. CONCLUSION: inpatients with a low plasma CoQ10 concentration, CoQ10 supply may decrease the tinnitus expression. SIGNIFICANCE: This is the first study to examine the effect of CoQ10 in chronic tinnitus aurium. (c) 2007 American Academy of Otolaryngology-Head and Neck Surgery Foundation. All rights reserved. C1 Charite Univ Med Berlin CCM, Tinnitus Ctr, Dept Otorhinolaryngol, D-10117 Berlin, Germany. Charite Univ Med Berlin CCM, Dept Internal Med, Berlin, Germany. Charite Univ Med Berlin CCM, Div Psychosomat & Psychotherapy, Berlin, Germany. Charite Univ Med Berlin CCM, Dept Phys Med & Rehabil, Berlin, Germany. Inst Med Diagnost, Berlin, Germany. Univ Witten Herdecke, Vest Kinderklin Datteln, Datteln, Germany. RP Mazurek, B (reprint author), Charite Univ Med Berlin CCM, Tinnitus Ctr, Dept Otorhinolaryngol, Schumannstr 20-21, D-10117 Berlin, Germany. EM birgit.mazurek@charite.de CR Beal MF, 2004, J BIOENERG BIOMEMBR, V36, P381, DOI 10.1023/B:JOBB.0000041772.74810.92 Cano Climaco P, 2003, Am J Ther, V10, P473, DOI 10.1097/00045391-200311000-00018 Crane FL, 2001, J AM COLL NUTR, V20, P591 Georgiewa P, 2006, MED HYPOTHESES, V66, P592, DOI 10.1016/j.mehy.2005.08.050 Goebel G, 1998, TINNITUS FRAGEBOGEN Harter M, 2005, HNO, V53, P707, DOI 10.1007/s00106-004-1181-2 HILLER W, 1992, J PSYCHOSOM RES, V36, P337, DOI 10.1016/0022-3999(92)90070-I Joachims HZ, 2003, OTOL NEUROTOL, V24, P572, DOI 10.1097/00129492-200307000-00007 Kaltenbach JA, 2002, J NEUROPHYSIOL, V88, P699, DOI 10.1152/jn00893.2001 Kwong LK, 2002, FREE RADICAL BIO MED, V33, P627, DOI 10.1016/S0891-5849(02)00916-4 Liu JK, 1996, FASEB J, V10, P1532 Mariani E, 2005, J CHROMATOGR B, V827, P65, DOI 10.1016/j.jchromb.2005.04.023 Muller T, 2003, NEUROSCI LETT, V341, P201, DOI 10.1016/S0304-3940(03)00185-X Niklowitz P, 2004, CLIN CHIM ACTA, V342, P219, DOI 10.1016/j.ccn.2003.12.020 Roth E, 2004, CURR OPIN CLIN NUTR, V7, P161, DOI 10.1097/00075197-200403000-00010 Sivonova M, 2004, STRESS, V7, P183, DOI 10.1080/10253890400012685 Sohmiya M, 2004, J NEUROL SCI, V223, P161, DOI 10.1016/j.jns.2004.05.007 Somayajulu M, 2005, NEUROBIOL DIS, V18, P618, DOI 10.1016/j.nbd.2004.10.021 WARE JE, 1992, MED CARE, V30, P473, DOI 10.1097/00005650-199206000-00002 Weber C, 2002, J PSYCHOSOM RES, V52, P29, DOI 10.1016/S0022-3999(01)00281-1 NR 20 TC 7 Z9 8 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0194-5998 J9 OTOLARYNG HEAD NECK JI Otolaryngol. Head Neck Surg. PD JAN PY 2007 VL 136 IS 1 BP 72 EP 77 DI 10.1016/j.otohns.2006.07.010 PG 6 WC Otorhinolaryngology; Surgery SC Otorhinolaryngology; Surgery GA 125KT UT WOS:000243441500016 PM 17210337 ER PT J AU Witsell, DL Hanney, MT Stinnet, S Tucci, DL AF Witsell, David L. Hanney, Maureen T. Stinnet, Sandra Tucci, Debara L. TI Treatment of tinnitus with gabapentin: A pilot study SO OTOLOGY & NEUROTOLOGY LA English DT Article DE tinnitus; quality of life; gabapentin AB Objective: To evaluate the effectiveness of gabapentin (Neurontin (R)) improve the disease-specific quality of life in patients with moderate tinnitus. Study Design: Randomized, double blind, placebo-controlled clinical trial. Setting: Single-center academic outpatient otolaryngology practice. Intervention: Gabapentin 1800 mg daily versus placebo. Main Outcome Measures: The study design is a randomized, double blind placebo controlled single site trial conducted in an academic medical center. Inclusion criteria included patients between ages 18 and 70 with a complaint of nonpulsatile, subjective tinnitus, bilateral or unilateral, greater than 3 months in duration. The primary outcome measure is the Tinnitus Handicap Inventory; secondary measures include the Profile of Mood States (POMS) rating scale, subjective tinnitus severity. The null hypothesis addressed in this study is that the drug would not result in significant alleviation of the symptom of tinnitus. Results: Seventy-six patients completed the trial; of these 52 received the drug. No significant differences were found between the two groups after 5 weeks of treatment with gabapentin. Conclusion: There is insufficient evidence to support the effectiveness of gabapentin in the treatment of tinnitus. C1 Duke Univ, Med Ctr, Dept Surg, Div Otolaryngol Head & Neck Surg, Durham, NC USA. RP Witsell, DL (reprint author), Duke Univ, Med Ctr, Dept Surg, Div Otolaryngol Head & Neck Surg, Durham, NC USA. EM witse001@mc.duke.edu CR Arnold W, 1996, ORL J OTO-RHINO-LARY, V58, P195 Bauer CA, 2000, HEARING RES, V147, P175, DOI 10.1016/S0378-5955(00)00130-1 Bauer CA, 2001, JARO, V2, P54 DENHARTIGH J, 1993, CLIN PHARMACOL THER, V54, P415 Eggermont JJ, 2005, DRUG DISCOV TODAY, V10, P1283, DOI 10.1016/S1359-6446(05)03542-7 EHRENBERGER K, 1995, ACTA OTO-LARYNGOL, V115, P236, DOI 10.3109/00016489509139299 HOUSE JW, 1981, ANN OTO RHINOL LARYN, V90, P597 IRELAND CE, 1985, BEHAV RES THER, V23, P423, DOI 10.1016/0005-7967(85)90170-6 Lockwood AH, 1998, NEUROLOGY, V50, P114 MAJUMDAR B, 1983, CLIN OTOLARYNGOL, V8, P175, DOI 10.1111/j.1365-2273.1983.tb01423.x MELDING PS, 1979, J LARYNGOL OTOL, V93, P111, DOI 10.1017/S0022215100086837 MIHAIL RC, 1988, ANN OTO RHINOL LARYN, V97, P120 NEWMAN C, 1995, P 5 INT TINN SEM, P186 Simpson JJ, 1999, TRENDS PHARMACOL SCI, V20, P12, DOI 10.1016/S0165-6147(98)01281-4 Taylor CP, 1998, EPILEPSY RES, V29, P233 NR 15 TC 28 Z9 29 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1531-7129 J9 OTOL NEUROTOL JI Otol. Neurotol. PD JAN PY 2007 VL 28 IS 1 BP 11 EP 15 DI 10.1097/01.mao.0000235967.53474.93 PG 5 WC Clinical Neurology; Otorhinolaryngology SC Neurosciences & Neurology; Otorhinolaryngology GA 124IF UT WOS:000243360800003 PM 17106432 ER PT J AU Otto, KJ Hudgins, PA Abdelkafy, W Mattox, DE AF Otto, Kristen J. Hudgins, Patricia A. Abdelkafy, Wael Mattox, Douglas E. TI Sigmoid sinus diverticulum: A new surgical approach to the correction of pulsatile tinnitus SO OTOLOGY & NEUROTOLOGY LA English DT Article; Proceedings Paper CT Annual Meeting of the American-Society-of-Pediatric-Otolaryngology CY APR 22, 2006 CL Chicago, IL SP Amer Soc Pediat Otolaryngol DE computed tomographic angiography; pulsatile tinnitus; sigmoid sinus diverticulum ID CT AB Objective: Tinnitus represents a bothersome symptom not infrequently encountered in an otology practice. Tinnitus can be the harbinger of identifiable middle or inner ear abnormality; but more frequently, tinnitus stands alone as a subjective symptom with no easy treatment. When a patient complains of tinnitus that is pulsatile in nature, a thorough workup is indicated to rule out vascular abnormality. We report of a new diagnostic finding and method of surgical correction for select patients with pulsatile tinnitus. Study Design: Retrospective case series. Setting: Tertiary care, academic referral center. Patients: Among patients seen for complaints of unilateral or bilateral pulsatile tinnitus, five were identified with diverticula of the sigmoid sinus. All patients had normal in-office otoscopic, tympanometric, and audiometric evaluations. Patients with paragangliomas or benign intracranial hypertension were excluded. Auscultation of the pinna or mastoid revealed an audible bruit in most patients. All patients underwent computed tomographic angiography of the temporal bone. In all cases, this finding was on the side coincident with the tinnitus. Intervention: Three of five patients underwent transmastoid reconstruction of the sigmoid sinus. Main Outcome Measure: Patients were evaluated clinically for presence or absence of pulsatile tinnitus after reconstructive surgery. Results: All patients electing surgical reconstruction had immediate and lasting resolution of the tinnitus. Conclusion: Surgical reconstruction can provide lasting symptom relief for patients with pulsatile tinnitus and computed tomographic evidence of a siginoid sinus diverticulum. C1 Emory Univ, Dept Otolaryngol, Sch Med, Atlanta, GA 30322 USA. Emory Univ, Dept Radiol, Sch Med, Atlanta, GA 30322 USA. Suez Canal Univ, Sch Med, Dept Otolaryngol, Ismailia, Egypt. RP Mattox, DE (reprint author), Emory Univ, Dept Otolaryngol, Sch Med, 1365 A Clifton Rd,Room 2375, Atlanta, GA 30322 USA. EM Douglas.Mattox@emoryhealthcare.org CR Houdart E, 2000, ANN NEUROL, V48, P669, DOI 10.1002/1531-8249(200010)48:4<669::AID-ANA16>3.0.CO;2-6 JASTREBOFF PJ, 1998, OTOLARYNGOLOGY HEAD, V4, P3198 Koesling S, 2005, EUR J RADIOL, V54, P335, DOI 10.1016/j.ejrad.2004.09.003 Krishnan A, 2006, AM J NEURORADIOL, V27, P1635 Sanchez Tanit Ganz, 2002, Int Tinnitus J, V8, P54 Sismanis A, 2003, OTOLARYNG CLIN N AM, V36, P389, DOI 10.1016/S0030-6665(02)00169-X NR 6 TC 27 Z9 39 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1531-7129 J9 OTOL NEUROTOL JI Otol. Neurotol. PD JAN PY 2007 VL 28 IS 1 BP 48 EP 53 DI 10.1097/01.mao.0000247814.85829.f6 PG 6 WC Clinical Neurology; Otorhinolaryngology SC Neurosciences & Neurology; Otorhinolaryngology GA 124IF UT WOS:000243360800009 PM 17195746 ER PT J AU Chien, HF Sanchez, TG Sennes, LU Barbosa, ER AF Chien, Hsin Fen Sanchez, Tanit Ganz Sennes, Luiz Ubirajara Barbosa, Egberto Reis TI Endonasal approach of salpingopharyngeus muscle for the treatment of ear click related to palatal tremor SO PARKINSONISM & RELATED DISORDERS LA English DT Article DE palatal tremor; tinnitus; botulinum toxin AB Palatal tremor (PT) is a rare disease associated with rhythmic movements of the soft palate. It can be separated into two distinct clinical entities: symptomatic and essential. Most patients with essential PT complain of the rhythmic ear clicks and in some cases tinnitus, but usually have an uneventful medical history. Symptomatic PT patients are often unaware of the palatal movements and have symptoms and signs of brainstem or cerebellar dysfunction. We describe the case of a 25-year-old patient who developed severe essential PT, with very distressing bilateral objective tinnitus, constantly perceived as ear clicks. Several oral medications were prescribed with poor results. No significant improvement was obtained with repetitive injections of botulinum toxin type A (BTX A) distributed in soft palate muscles. Because of the continuous tinnitus and its impact on the patient's quality of life, chemical denervation of the salpingopharyngeus muscles, which is involved in the production of finnitus, with BTX A was performed endonasally under endoscopic guidance. The result was very satisfactory. Tinnitus due to essential PT may be satisfactorily treated by endonasal injection of BTX into the salpingopharyngeus and palatopharyngeus muscles. (C) 2006 Elsevier Ltd. All rights reserved. C1 Univ Sao Paulo, Sch Med, Dept Neurol, Movement Disorders Clin, Sao Paulo, Brazil. Univ Sao Paulo, Sch Med, Dept Otolaryngol, Sao Paulo, Brazil. RP Chien, HF (reprint author), Univ Sao Paulo, Sch Med, Dept Neurol, Movement Disorders Clin, Sao Paulo, Brazil. EM chien.74@fmusp.org.br RI Sennes, Luiz/E-6815-2012; Barbosa, Egberto/G-7763-2012 CR Bento R F, 1998, Ear Nose Throat J, V77, P814 Bertola DR, 2000, PEDIATR DERMATOL, V17, P218, DOI 10.1046/j.1525-1470.2000.01756.x DEUSCHL G, 1994, MOVEMENT DISORD, V9, P676, DOI 10.1002/mds.870090615 DEUSCHL G, 1991, NEUROLOGY, V41, P1677 Ensink RJH, 2003, OTOL NEUROTOL, V24, P714, DOI 10.1097/00129492-200309000-00003 Jamieson DRS, 1996, NEUROLOGY, V46, P1168 Nishie M, 2002, BRAIN, V125, P1348, DOI 10.1093/brain/awf126 Nitschke MF, 2001, MOVEMENT DISORD, V16, P1193, DOI 10.1002/mds.1202 Samuel M, 2004, MOVEMENT DISORD, V19, P717, DOI 10.1002/mds.20034 Sismanis A, 2003, OTOLARYNG CLIN N AM, V36, P389, DOI 10.1016/S0030-6665(02)00169-X NR 10 TC 3 Z9 4 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1353-8020 J9 PARKINSONISM RELAT D JI Parkinsonism Relat. Disord. PY 2007 VL 13 IS 4 BP 254 EP 256 DI 10.1016/j.parkreldis.2006.05.004 PG 3 WC Clinical Neurology SC Neurosciences & Neurology GA 172SO UT WOS:000246824600011 PM 16828572 ER PT J AU Kleinjung, T Fischer, B Langguth, B Sand, PG Hajak, G Dvorakova, J Eichhammer, P AF Kleinjung, Tobias Fischer, Birgit Langguth, Berthold Sand, Philipp G. Hajak, Goeran Dvorakova, Jana Eichhammer, Peter TI Validation of the German-version Tinnitus Handicap Inventory (THI) SO PSYCHIATRISCHE PRAXIS LA German DT Article; Proceedings Paper CT Regional Research Conference of the Psychiatric and Neurological Special Clinics of Bavaria ` CY OCT 12-14, 2005 CL Bavaria, GERMANY SP Educ Inst Assoc Bavarian Sectors HO Educ Inst Kloster Irsee DE questionnaire; tinnitus; tinnitus handicap inventory; validation AB Objective Tinnitus counts among the most debilitating auditory handicaps and is often complicated by insomnia, concentration difficulties, depression, frustration and irritability. To facilitate the grading of symptoms, we validated a German-version Tinnitus Handicap Inventory (THI) in 74 subjects suffering from chronic tinnitus. Methods Outcome validity was assessed using the Tinnitus Questionnaire (TQ, German adaptation by Goebel u. Hiller [1998]). Construct validity was assessed using the Beck Depression Inventory (BDI). Results The German THI featured excellent internal consistency (total score Cronbach's alpha =0.93). Factor analysis disclosed three THI subscales as proposed earlier by Newman et al. [1996]. Inter-correlations were strong both between the THI and the TQ (r=0.70), and between the THI and the BDI (r=0.64). Conclusions The German-version THI qualifies as a rapid and statistically robust tool for grading the impact of tinnitus on daily living. With regard to depressive symptomatology, sensitivity of the THI was comparable to that of the TQ. C1 Bezirksklinikum Regensburg Univ, Klin & Poliklin Psychiat Psychosomat & Psychother, D-93053 Regensburg, Germany. Univ Regensburg, Klin Hals Nasen Ohren Heilkunde, D-8400 Regensburg, Germany. Karls Univ, Fak Med 1, Psychiat Klin, Prague, Czech Republic. RP Sand, PG (reprint author), Bezirksklinikum Regensburg Univ, Klin & Poliklin Psychiat Psychosomat & Psychother, Univ Str 84, D-93053 Regensburg, Germany. EM philipp.sand@klinik.uni-regensburg.de RI Sand, Philipp/C-1924-2009 OI Sand, Philipp/0000-0001-5806-5841 CR Goebel G, 1998, INSTRUMENT ERFASSUNG Greimel KV, 1999, HNO, V47, P196, DOI 10.1007/s001060050382 HALLAM RS, 1988, BRIT J CLIN PSYCHOL, V27, P213 Hannaford PC, 2005, FAM PRACT, V22, P227, DOI 10.1093/fampra/cmi004 Heller AJ, 2003, OTOLARYNG CLIN N AM, V36, P239, DOI 10.1016/S0030-6665(02)00160-3 Herráiz C, 2001, Acta Otorrinolaringol Esp, V52, P534 HILLER W, 1998, TINNITUS PSYCHOSOMAT, P63 McCombe A, 2001, CLIN OTOLARYNGOL, V26, P388, DOI 10.1046/j.1365-2273.2001.00490.x Newman CW, 1996, ARCH OTOLARYNGOL, V122, P143 Zachariae R, 2000, SCAND AUDIOL, V29, P37, DOI 10.1080/010503900424589 NR 10 TC 5 Z9 5 PU GEORG THIEME VERLAG KG PI STUTTGART PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY SN 0303-4259 EI 1439-0876 J9 PSYCHIAT PRAX JI Psychiatr. Prax. PD JAN PY 2007 VL 34 SU 1 BP S140 EP S142 DI 10.1055/s-2006-940218 PG 3 WC Psychiatry SC Psychiatry GA 151HE UT WOS:000245280300058 ER PT J AU Schlee, W Weisz, N Hartmann, T Dohrmann, K Elbert, T AF Schlee, Winfried Weisz, Nathan Hartmann, Thomas Dohrmann, Katalin Elbert, Thomas TI Altered resting-state brain connectivity in tinnitus patients revealed by phase-synchrony analysis SO PSYCHOPHYSIOLOGY LA English DT Meeting Abstract CT 47th Annual Meeting of the Society-for-Psychophysiological-Research CY OCT 16-21, 2007 CL Savannah, GA C1 Univ Konstanz, D-7750 Constance, Germany. INSERM, U821, F-69008 Lyon, France. RI Elbert, Thomas/C-8556-2009 NR 0 TC 0 Z9 0 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 0048-5772 J9 PSYCHOPHYSIOLOGY JI Psychophysiology PY 2007 VL 44 SU 1 BP S79 EP S79 PG 1 WC Psychology, Biological; Neurosciences; Physiology; Psychology; Psychology, Experimental SC Psychology; Neurosciences & Neurology; Physiology GA 203VK UT WOS:000249001900359 ER PT J AU Dohrmann, K Elbert, T Schlee, W Weisz, N AF Dohrmann, Katalin Elbert, Thomas Schlee, Winfried Weisz, Nathan TI Tuning the tinnitus percept by modification of synchronous brain activity SO RESTORATIVE NEUROLOGY AND NEUROSCIENCE LA English DT Article DE tinnitus; EEG; neurofeedback; perceptual coding ID HUMAN AUDITORY-CORTEX; REORGANIZATION; ALPHA AB Purpose: Tinnitus, the perception of sound without the presence of a physical stimulus, provides the opportunity to study neural codes of percepts without simultaneous processing of stimuli. Previously, we have found that tinnitus is associated with enhanced delta- and reduced tau-power in temporal brain regions. By operantly modifying corresponding aspects of spontaneous EEG activity, the aim of the present study was to corroborate the assumption that tinnitus should be reduced if patterns of ongoing synchronous brain activity are normalised. Methods: In response to different variants of neurofeedback, a total of twenty-one patients produced significant changes in EEG frequency bands. Results: Simultaneous alteration of both frequency bands was strongly related to changes in tinnitus intensity matched before and after the intervention (r = -0.74). In those two patients with the greatest modulatory success, the tinnitus sensation resided completely in response to the treatment. Comparing the neurofeedback-treated patients with a group of patients trained with a frequency discrimination task (n = 27), the tinnitus relief in the neurofeedback group was significantly stronger. Conclusions: This study supports the notion that altered patterns of intrinsic ongoing brain activity lead to phantom percepts and offer new routes to the treatment of tinnitus. C1 Univ Konstanz, Dept Psychol, D-78457 Constance, Germany. INSERM, Ctr Hosp Le Vinatier, U821, F-69500 Bron, France. RP Dohrmann, K (reprint author), Univ Konstanz, Dept Psychol, Box D 25, D-78457 Constance, Germany. EM Katalin.Dohrmann@uni-konstanz.de RI Elbert, Thomas/C-8556-2009; Schlee, Winfried/C-8983-2011 OI Schlee, Winfried/0000-0001-7942-1788 CR AXELSSON A, 1989, British Journal of Audiology, V23, P53, DOI 10.3109/03005368909077819 Eggermont JJ, 2004, TRENDS NEUROSCI, V27, P676, DOI 10.1016/j.tins.2004.08.010 Elbert T, 1984, SELF REGULATION BRAI Elbert T, 2004, NEUROSCIENTIST, V10, P129, DOI 10.1177/1073858403262111 Engel AK, 2001, TRENDS COGN SCI, V5, P16, DOI 10.1016/S1364-6613(00)01568-0 Flor H, 2004, APPL PSYCHOPHYS BIOF, V29, P113, DOI 10.1023/B:APBI.0000026637.77671.f4 Goebel G, 1998, TINNITUS FRAGEBOGEN Gosepath K, 2001, HNO, V49, P29, DOI 10.1007/s001060050704 Hari R, 1997, TRENDS NEUROSCI, V20, P44, DOI 10.1016/S0166-2236(96)10065-5 Jeanmonod D, 1996, BRAIN, V119, P363, DOI 10.1093/brain/119.2.363 Lehtela L, 1997, NEUROSCI LETT, V222, P111, DOI 10.1016/S0304-3940(97)13361-4 Llinas R, 2005, TRENDS NEUROSCI, V28, P325, DOI 10.1016/j.tins.2005.04.006 Muhlnickel W, 1998, P NATL ACAD SCI USA, V95, P10340, DOI 10.1073/pnas.95.17.10340 NORENA A, 2003, HEARING RES, V163, P137 Norena A, 2002, AUDIOL NEURO-OTOL, V7, P358, DOI 10.1159/000066156 PANTEV C, 1995, ELECTROEN CLIN NEURO, V94, P26, DOI 10.1016/0013-4694(94)00209-4 Sauseng P, 2005, INT J PSYCHOPHYSIOL, V57, P97, DOI 10.1016/j.ijpsycho.2005.03.018 Schenk S, 2005, HNO, V53, P29, DOI 10.1007/s00106-004-1066-4 Shiomi Y, 1997, HEARING RES, V108, P83, DOI 10.1016/S0378-5955(97)00043-9 WEISZ N, IN PRESS NEURAL CODE Weisz N, 2005, PLOS MED, V2, P546, DOI 10.1371/journal.pmed.0020153 WEISZ N, 2006, HEARING RES NR 22 TC 23 Z9 23 PU IOS PRESS PI AMSTERDAM PA NIEUWE HEMWEG 6B, 1013 BG AMSTERDAM, NETHERLANDS SN 0922-6028 J9 RESTOR NEUROL NEUROS JI Restor. Neurol. Neurosci. PY 2007 VL 25 IS 3-4 BP 371 EP 378 PG 8 WC Neurosciences SC Neurosciences & Neurology GA 239JE UT WOS:000251513800015 PM 17943012 ER PT J AU Staal, M Bartels, H AF Staal, M. Bartels, H. TI Long-term evaluation of treatment of chronic, therapeutically refractory Tinnitus with neurostimulation SO STEREOTACTIC AND FUNCTIONAL NEUROSURGERY LA English DT Meeting Abstract C1 Univ Groningen, Med Ctr, NL-9700 RB Groningen, Netherlands. NR 0 TC 0 Z9 0 PU KARGER PI BASEL PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND SN 1011-6125 J9 STEREOT FUNCT NEUROS JI Stereotact. Funct. Neurosurg. PY 2007 VL 85 IS 1 BP 49 EP 49 PG 1 WC Neurosciences; Neuroimaging; Surgery SC Neurosciences & Neurology; Surgery GA 113SE UT WOS:000242616800077 ER EF